CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP025206	Lactobacillus sakei strain WiKim0074 chromosome, complete genome	2 crisprs	cas3,csa3,DEDDh	1	0	6
NZ_CP025208	Lactobacillus sakei strain WiKim0074 plasmid pLSW74_2, complete sequence	0 crisprs	NA	0	0	0
NZ_CP025207	Lactobacillus sakei strain WiKim0074 plasmid pLSW74_1, complete sequence	1 crisprs	csa3	0	2	2

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP025206_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025206_1

915284-915690

Orphan

Consensus_repeat	Method
GTATCCCAATTCGAAACATCTAA	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_CP025206_1

>merge|NZ_CP025206|1|915284-915690|CRISPRCasFinder
GTTTGCCACTTAGAAACGTCTAACTGCGTTAATCTTTGATCACCGCTGAACGTGTAAGACAACGATGTATTTTTGCCGAGCTGCCATTTTGAGACATCTAAGGTTTCAAGTCTTGAACATCCCGAAAAAGTATAAGCCATTGTCGTCACTTGGCTTGTATCCCAATTCGAAACATCTAATTCGGCAATACTAGTATTCAGAAAAGTACTACTTAAATTAGTAACGTGACTGGTATCCCAATTTGAAACATCTAAAACAGTAATGCCCGATTGTGAAAAGGTACTCCCCAGATTAGTCATTTTTGCCGTCTGCCATTTTGAAACATCTAAGTTCGTTAAGGCCGTACAATTGAAAAATGTGTTATTCATATTTTGAATATTAGAAGTGTCCCAATTCGTACTATTTAG

>NZ_CP025206|1|1|915284-915690|CRISPRCasFinder
GTTTGCCACTTAGAAACGTCTAA	CTGCGTTAATCTTTGATCACCGCTGAACGTGTAAGACAACGATGTATTTTTGCCG
AGCTGCCATTTTGAGACATCTAA	GGTTTCAAGTCTTGAACATCCCGAAAAAGTATAAGCCATTGTCGTCACTTGGCTT
GTATCCCAATTCGAAACATCTAA	TTCGGCAATACTAGTATTCAGAAAAGTACTACTTAAATTAGTAACGTGACTG
GTATCCCAATTTGAAACATCTAA	AACAGTAATGCCCGATTGTGAAAAGGTACTCCCCAGATTAGTCATTTTTGCC
GTCTGCCATTTTGAAACATCTAA	GTTCGTTAAGGCCGTACAATTGAAAAATGTGTTATTCATATTTTGAATATTAGAA
GTGTCCCAATTCGTACTATTTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025206.1\|WP_025016109.1\|926674_927070_-\|D-ribose-pyranase	unknown	unknown	gnl\|CDD\|183318
NZ_CP025206.1\|WP_025016102.1\|912144_913182_-\|DUF916-and-DUF3324-domain-containing-protein	unknown	unknown	gnl\|CDD\|371730
NZ_CP025206.1\|WP_016264496.1\|918529_919066_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225786
NZ_CP025206.1\|WP_025016108.1\|925746_926655_-\|ribokinase	unknown	unknown	gnl\|CDD\|274000
NZ_CP025206.1\|WP_011373916.1\|921620_922310_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|172606
NZ_CP025206.1\|WP_157697960.1\|911069_911246_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372694
NZ_CP025206.1\|WP_025016099.1\|909648_909933_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197670
NZ_CP025206.1\|WP_011373914.1\|923961_924516_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP025206.1\|WP_052039193.1\|911248_911926_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025206.1\|WP_025016100.1\|909925_910360_-\|DUF3324-domain-containing-protein	unknown	unknown	gnl\|CDD\|371730
NZ_CP025206.1\|WP_025016097.1\|906498_907488_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375451
NZ_CP025206.1\|WP_025016096.1\|906064_906367_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|366278
NZ_CP025206.1\|WP_011373915.1\|922405_923965_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP025206.1\|WP_025016098.1\|907497_909417_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375450
NZ_CP025206.1\|WP_035145629.1\|913255_914128_-\|WxL-domain-containing-protein	unknown	unknown	gnl\|CDD\|372694
NZ_CP025206.1\|WP_056936442.1\|919101_921225_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
NZ_CP025206.1\|WP_025016106.1\|917855_918473_+\|DUF1361-domain-containing-protein	unknown	unknown	gnl\|CDD\|369208
NZ_CP025206.1\|WP_025016101.1\|910414_910978_-\|DUF916-domain-containing-protein	unknown	unknown	gnl\|CDD\|368712
NZ_CP025206.1\|WP_025016105.1\|916666_917659_-\|choloylglycine-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238303
NZ_CP025206.1\|WP_035145621.1\|924659_925682_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525

Protein	Function_ID	Function_description	E-value
NZ_CP025206.1\|WP_025016109.1\|926674_927070_-\|D-ribose-pyranase	gnl\|CDD\|183318	PRK11797, PRK11797, D-ribose pyranase; Provisional.	4.56237e-74
NZ_CP025206.1\|WP_025016102.1\|912144_913182_-\|DUF916-and-DUF3324-domain-containing-protein	gnl\|CDD\|371730	pfam11797, DUF3324, Protein of unknown function C-terminal (DUF3324). This family consists of several hypothetical bacterial proteins of unknown function.	5.18202e-43
NZ_CP025206.1\|WP_016264496.1\|918529_919066_-\|hypothetical-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	4.18527e-14
NZ_CP025206.1\|WP_025016108.1\|925746_926655_-\|ribokinase	gnl\|CDD\|274000	TIGR02152, Putative_ribokinase, ribokinase. This model describes ribokinase, an enzyme catalyzing the first step in ribose catabolism. The rbsK gene encoding ribokinase typically is found with ribose transport genes. Ribokinase belongs to the carbohydrate kinase pfkB family (pfam00294). In the wide gulf between the current trusted (360 bit) and noise (100 bit) cutoffs are a number of sequences, few of which are clustered with predicted ribose transport genes but many of which are currently annotated as if having ribokinase activity. Most likely some have this function and others do not. [Energy metabolism, Sugars].	2.55136e-126
NZ_CP025206.1\|WP_011373916.1\|921620_922310_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|172606	PRK14116, gpmA, 2,3-diphosphoglycerate-dependent phosphoglycerate mutase.	1.12494e-164
NZ_CP025206.1\|WP_157697960.1\|911069_911246_-\|hypothetical-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	0.00128998
NZ_CP025206.1\|WP_025016099.1\|909648_909933_-\|hypothetical-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.51461e-06
NZ_CP025206.1\|WP_011373914.1\|923961_924516_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.48625e-10
NZ_CP025206.1\|WP_025016106.1\|917855_918473_+\|DUF1361-domain-containing-protein	gnl\|CDD\|369208	pfam07099, DUF1361, Protein of unknown function (DUF1361). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.	1.89048e-27
NZ_CP025206.1\|WP_025016100.1\|909925_910360_-\|DUF3324-domain-containing-protein	gnl\|CDD\|371730	pfam11797, DUF3324, Protein of unknown function C-terminal (DUF3324). This family consists of several hypothetical bacterial proteins of unknown function.	7.04333e-16
NZ_CP025206.1\|WP_025016097.1\|906498_907488_-\|hypothetical-protein	gnl\|CDD\|375451	pfam17966, Mub_B2, Mub B2-like domain. This entry corresponds to the Mub B2 domain. This domain is related to the Mub B1 domain pfam17965. This domain may be involved in mucin binding. This domain is often found associated with the related pfam17965 in bacterial cell surface proteins.	5.14977e-17
NZ_CP025206.1\|WP_025016096.1\|906064_906367_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|366278	pfam00746, Gram_pos_anchor, LPXTG cell wall anchor motif.	6.9213e-05
NZ_CP025206.1\|WP_011373915.1\|922405_923965_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.83511e-67
NZ_CP025206.1\|WP_025016098.1\|907497_909417_-\|hypothetical-protein	gnl\|CDD\|375450	pfam17965, MucBP_2, Mucin binding domain. This domain is found in bacterial cell surface proteins that interact with mucins. The archetypal member of this family is the Mub-R5 B1 domain. This domain has a beta-grasp fold.	1.10213e-12
NZ_CP025206.1\|WP_035145629.1\|913255_914128_-\|WxL-domain-containing-protein	gnl\|CDD\|372694	pfam13731, WxL, WxL domain surface cell wall-binding. The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localization function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.	1.3377e-16
NZ_CP025206.1\|WP_056936442.1\|919101_921225_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP025206.1\|WP_025016101.1\|910414_910978_-\|DUF916-domain-containing-protein	gnl\|CDD\|368712	pfam06030, DUF916, Bacterial protein of unknown function (DUF916). This family consists of several hypothetical bacterial proteins of unknown function.	3.84271e-31
NZ_CP025206.1\|WP_025016105.1\|916666_917659_-\|choloylglycine-hydrolase-family-protein	gnl\|CDD\|238303	cd00542, Ntn_PVA, Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which PVA belongs. This nucleophilic cysteine is exposed by post-translational prossessing of the PVA precursor. PVA forms a homotetramer.	1.30921e-149
NZ_CP025206.1\|WP_035145621.1\|924659_925682_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	2.93039e-104

>NZ_CP025206.1|WP_035145629.1|913255_914128_-|WxL-domain-containing-protein
MSQPVTSNTVDMNVVQSEHQLTIRYVDLDEDLSQPASAGTQIAAPITVSGKTGTALSTLLPGQQVAPKVIEGYTIYSVSEDPDLKPENWQKAYRDDPQIGDQDRIITYGYKKAMLSIDAPSSWEFGDYNNKPMDRTYYLNHNQGTPQAVTVTDNYGVQNWQLQVSQAKPFVDSEQHELTDAKWAFSNGNVKTLSNTDVGTVTNNSEHFTLASGQSATLMTMTKSGHFQSDSPDTSDPENPYTQVGQGQWAYRFGDEKSADYSIGLNVPATTKRYTGHYRTKLTWSLSVGP
>NZ_CP025206.1|WP_025016102.1|912144_913182_-|DUF916-and-DUF3324-domain-containing-protein
MRLRKWTTGLAVGLFGWLLLASNQPVSAAQEHIDFEVEKVKSNRQVDQENRFFDLGIEPGKKETIQVLVHNFSDKNIKVHSEIDNSLTQQGGGIIYRPTKDGIIKETSHTLMDVAKVHRADRVITLGPNEVKKVSATITMPSEQTKGMIYGAWHFIEYGQKETDNHSNVSGSYAYNMGIVLRGKPYEIYPELKYQGVNPTVRNGHPALGIQLNNTKPMAIKNAKVKAVVYKNGFFKDKRVYETDSVDVAPNSQWTVPISWAFDRLKPGRYNISISVKGNSYWNQLPMSWHFRKKITINQQQADKINQASVKKPVNKWAYVATASGILMLVSFWFVYRVLKLTRGL
>NZ_CP025206.1|WP_052039193.1|911248_911926_-|hypothetical-protein
MKFTKLTSTVLTASTLLAILAPATIASAATPKDDAAANGGTKLPMTDTTDAGISFGDTHDNGNSGYLRLQMVPKTLDFGNHAKYDAAHTNFDATGANLGVVGNDTHASYDQQDSNKTEILTTSDANLKAVQGTAWATVVDKQVENPELAAATPKANTAGDWKLTVSADGDGLKAGGHTIADANLVFGNTKYGRTADIYGLTNQDQDNDGYTALGQQMQHTQNQLA
>NZ_CP025206.1|WP_157697960.1|911069_911246_-|hypothetical-protein
MSTPNEEKVVGTAAKDAGDGANVFGWNPSDIRLALNGSNDVATGEYHAGLTWTLNTTI
>NZ_CP025206.1|WP_025016101.1|910414_910978_-|DUF916-domain-containing-protein
MFKRLNMLWFCLILVDLLTVQTSNPVFAKSEGLAIPAEPKATFMLRPELPKDNLGCKRLGYFNLKLKRGQQRTVFLKVFNPTAQPLTIYGRVKDATTNDNATVDYLGANPIDRQLLKQPGSQLVKVPRATKLQPNETKRLKVTIQAPAKGFKGQKATAINLSTNQLAKHNAVENHYVYAITLILNGR
>NZ_CP025206.1|WP_025016100.1|909925_910360_-|DUF3324-domain-containing-protein
MKQKRAAISVAIANPNPAYLKSATVKVDLQNQQWSLIRYQDQKSNRKIAPNSRFYEDVPLGGKRLVAGVYRMTLTIKTAHQQQIIHKNIAISKGQARYINQNNDQYLKYRNLLLLGGFVMVLMGVIGGYRILKVKHMKRDEHDD
>NZ_CP025206.1|WP_025016099.1|909648_909933_-|hypothetical-protein
MIKSEKNQYLEGYQLLTRLENGLDTIAKRHGVSFSQYLILKQIVENDCNEPSLLAKAFAISRPAMSRKLTVLFRNGKIKKLYNLKDEDQRITSL
>NZ_CP025206.1|WP_025016098.1|907497_909417_-|hypothetical-protein
MNREKGFRKVLLFGLALYVVGFGLGQDVTHSYATEASSDATLTSQLSSDSESTSSQSSSETLASETPKIAPETKGESTNPVKVMPSLAKTQTPVTQKVARAATTYKIQDLIDQGGVKTTVTWDIYSQSEDDISQGYTGTYYPKVIKFSVLPNNVLQPGDTISFSVLRYTGKLSGQGPVTMASVSLRELGQYDGKSLVLGSEYVPDKAVDASSDLPKSSGGVATLTNETTPDYTAAYAGSTINGTKSSVTVIPATHFNGFQVTNAAVGSDKKGTLTLSGYTKDQTYFQSALDGTPNLKGVPTANYVRIYRIDKESAQNINKVSFDLKTYMPALMPDGQHMAAKAGTTGPMLFIKAPAAVPINNSGSVAADATDDEIIAKTSPQTYGVLHNSDGSMTLYLNYGNLTRPYELPVDTITKGVMNNSWDGTQEGLDYALNRLSNNNYSALATSTYFTMNISFNDPSIENTVQATYKDTLNNTETINQPSSPPSASTDGQTTIKVHYADQNGKYIKPIETHYGWPDTDKLQITTQDLTIPGYTLDKSNLPKGADPDTGALTLSYPKEAGKVDDILYRFIQNKQKIDVTYVDDTTGKQLATDTMSGVVDENSKYNTQTKLAAYEKQGYQLVSDETNGATLLFSDQD
>NZ_CP025206.1|WP_025016097.1|906498_907488_-|hypothetical-protein
MHLKHAIKAAPDESKQVKRTIHYRYQSNKQAAPDVVDKITFTRHDQIDQVTNQSIGFTKWVSTEGTTTFAKQTSPVIKGYTADQLTVPAVENITQDSADITATVTYTGQAQKATVTYQRSDNQAVIQADQLTGVSGQISVYRTDATLAALADKGYTVADNPYPSDGLVFDDDVAVDQNVTVLLNYNPYYNRVYFKSVPSEMDFGQHTLASTTESYQPTVNQALSIQDERALGSKWTLKAALVQPFTGDTQKAPLEGDLTYQRANQLPTMITAQSTIIATTTTTSHDPVDISGQWQNQLGPQLVVPVGGALIDQYAAQVEWTLEDGVANE
>NZ_CP025206.1|WP_025016096.1|906064_906367_-|LPXTG-cell-wall-anchor-domain-containing-protein
MRWLKNKSKFVVLMLIIGSGLIVVNPTHTSANAQTATKSVARVGFYETGQPHKQAPIQTETKQQARLPQTGTSSVGLSTIVGIVLLIGSLGLFKQRRGNF
>NZ_CP025206.1|WP_025016105.1|916666_917659_-|choloylglycine-hydrolase-family-protein
MCTSLTYSTVDGHHFLARTMDFSFELNGNPLFLPRQHQWQPVLEKQAIQNQYALMGAGAKLGDQYLVADGFNEHGLGCAELYFAHAAVYEPQPVPNKLNLVAEEFIVWVLGNYQTLEEVAADLDNVRIIESDQGVMGANQPLHWILSDRSGKTMVIEPRGNGLQLIDDPVGVMTNTPDLDWHIKNLSNYLNLQPQPFMERPFGNYQAGPFSQGTGTQALPGSYTPPDRFVRAAYSRQYMPEANNVAEGVNHILHILDNVTIPKGVNIGSGGSSDYTQYQGISGLNNLAYYMVNYDNRHVYQTNLTTDLIENQKEPVIYHLPQGQQNTILN
>NZ_CP025206.1|WP_025016106.1|917855_918473_+|DUF1361-domain-containing-protein
MSKKVLTIHAIILLFFALILLYQSRFAFLIWNIILALIPFDLSLLGRLFKNSRWRYLIGVVWLLFFPNALYMITDFSHLSSIGVGLSTAFQFVEYAILAGGIFVGVTLGLTSLFILYPLFIPNYQRLVNQAATFGVLSVCSSVAIYIGRFLRINSWDVFYQLHTTIASVLGVLNQSDFWIFVIAFSILQLILMLMGYQLAQLDDL
>NZ_CP025206.1|WP_016264496.1|918529_919066_-|hypothetical-protein
MLSKNISNKLRQATGVNGLLSLILGLLILFLPGQSAMGVTVMVGVVFIIIGLFDILSIFKEVDENTWVRLGHLLLGLLYLIVGIFVCVNLAASATYLFLLVGIFVGITWLVEGFVELGTVRLAVSKGWTIFSAVLSIVAGIILLMTPLYGAVMLWTLLGAILVVLGIFKVAHYLAWQK
>NZ_CP025206.1|WP_056936442.1|919101_921225_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MANMYGNDPFFNNDMDDIFNQVFRRMGNSESARYVINGRELSPDEFAQYRATGKLPNREKEIEIKQNGEHALKKGGILEKLGRNLTQEARDGLLDPVIGRYNEIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQEIVAGKVPEAIKDKEIYSIDLSSLEAGTQYRGSFEENIKNLIKEVKAAGNVILFFDEIHQILGIGSTGGEDGGKGLADIIKPALSRGELTVIGATTQDEYRNTILKNAALARRFNDVLVNEPSAADTVKILQGIKGLYEKHHHIELPDDVLKAAVDYSAQYIPQRTLPDKAIDLLDMTAAHLAAKRPETDKAKLAAELKQLEADKAAAVEAENYQAAEELKVKIEKIKAQLATDDQHAAEVIATVDDIAQSVERLTGIPVAKMGSNDIQRLKNLGQRLKDKVIGQDEAVEMVARAIRRNRAGFSEGNQPIGSFLFVGPTGVGKTELAKQLALDMFGNKEAIIRLDMSEYADRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIVLFDEIEKADPQVLTLLLQVMDDGRLTDGQGNVIDFKNTVIIATSNAGFGNEKLTMNDQEDAKLLDKLAPYFRPEFLNRFNGIVEFTHLTKADLSQIVDLMLTNVEQTLAKKELTLVVSKEAKDWLMEEGYDEAMGARPLRRVIEQQIRDKVTDFYLDHADVKDLKADLVDDQIVIQAVDSEN
>NZ_CP025206.1|WP_011373916.1|921620_922310_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MAKLVFIRHGQSEWNLSNQFTGWVDVNLSEEGVRQAQNAGALLKKEGILFDQAYTSVLTRAIKTLHYALEGSDQLWIPETKSWRLNERHYGALQGQNKAEAAEKWGDEQVHIWRRSYDTLPPLLDASDEGSAANDRRYAHLDPKAIPGGENLKVTLERVIPFWEDEIAPKLIDGQNIIVAAHGNSLRALTKYIENISDEDIMDVEMATGEPVVYDLDENLNVVSKKKLN
>NZ_CP025206.1|WP_011373915.1|922405_923965_-|MFS-transporter
MKKTTNRWIALVAMSLGVFMGLLDVTVVNVALPSMAVDFKTTFSNLQWVLNAYTLMYAVSLLIVSKLGDMFGRKKIFIMSMILFTAASVVNGLAPNLLVLDIGRAIQAIGGSGMMSLSMALVASNFEGRERGTALGILGSVIGFSTAIGPLVGGFLVESFGWPSIFFVNLPVGIISVYLVIRNVKETPAYGAGESIDFMGMFLSAIGLFSGIYGLIQKEQHMHWAWTDMRIMGWLVASVLILALFVFVELKAKAPMMNLTLLTNRHFVGVVILAFSLGAGIFALAAYQTSLMQNYMGYSAFSTGVHQLPMSLWSLVLGPFTGVLGYKFGKKWLIAFGFTVSALGLLIFRQVTTTDFTYMQLLPLLALTGLGNAIINPMINTAAMDNINPQEIGMASGLLNVFRQIGITVGVVILGLSQTNAYESSLSTGFSGSSIPKAAATGIHQSLVEAGAFSGHAIAWGQQLVKTPYAAKVQQMVVTAFDKGMIAVVTTSLVLMVIAILAALFLLKETKSVDQKPQK
>NZ_CP025206.1|WP_011373914.1|923961_924516_-|PadR-family-transcriptional-regulator
MYELLMLSALMSRNMSGYKLRIILENAMLPRRKISNGVLYPLLDKLENKGCIGFDEADQDSRGTKIAHITEEGRRYFAELMTKPVAHDAKWDDAYRFKMRGMHYIDSEEQISILQDYRNELAEDLHVYLGIKNHLTDLRDEEGTNTNYYQWQVRSMDFVITTLKAKVDWLEAQIKEIEKMEIVK
>NZ_CP025206.1|WP_035145621.1|924659_925682_-|LacI-family-transcriptional-regulator
MGEVNVVRKVTIKDVAALAQTSVTTVSLILNNKGQRFSAETIARVRAAREKISYEPDYFAQNMVNKETKTIAVLVPDINNPFFSQFIQGVEEVAYQYDFIPLIYSAGQNNQKVNYYLKELVRRNVDGFILAVSHIEEETLEGHLKQRKIPYILLDQSEKQHQSDEIAVADTEGGRMAANYLIEKGHRQIGIVLPEQRAWNIEQRFIGYQAALVSHQITVNPDWQITTPLSKQGGYQVAQQVIDSGVSAVFAVNDELAIGLARGLAELGHAVPESISIIGYDDIDWCEYVTPRLTTIKQPILALGQEATRLLLNRIEKPTLGMQQKMLSVELVERDSVQAQ
>NZ_CP025206.1|WP_025016108.1|925746_926655_-|ribokinase
MKKVIVLGSTNVDTILNVQRFPQPGETLAMDGRAVAGGGKGANQAIAAVRSGAQTAFISKVGKEGAADFMIDTFKKDGMNVDHVRCSETAGTGQAYIMVDAQGQNSILIYGGANQDVTVEDVHEAETAIKAADRIVAQFEVPIPAIIEAFKIARANGVQTILNPAPAIKNIPAELLAVTDMIVPNETEAEIITGIKVTDEASMQANAEAMFKLGIKVVIITVGSKGSFYATPTATGFVPAFKVNAVDTTAAGDTFIGALSTKLELDYSNIEAAMTYANKASSIAVQTKGAQNSIPYEKDIQL
>NZ_CP025206.1|WP_025016109.1|926674_927070_-|D-ribose-pyranase
MRKTKVINTQISSVISDMGHFDTLSIGDAGMPVPAGTKKIDVAIENGVPSFIQVLTNILSELEVQKVYLANEIKTANPEQLAAIKALIGETPIEFIDHSQMKQDLNKAKAFVRTGEMTPYSNIILESGVVF

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Crispr_ID: NZ_CP025206_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025206_2

1433138-1433221

Unclear

Consensus_repeat	Method
CTAGCACTAATGGCACGTTTAAA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP025206_2

>merge|NZ_CP025206|2|1433138-1433221|CRISPRCasFinder
CTAGCACTAATGGCACGTTTAAAAATTAGAGTGCTTTTAGTGCTTGTTTAGATTTTGAGCACTAGCACTAATAGCACGTTTAAA

>NZ_CP025206|2|2|1433138-1433221|CRISPRCasFinder
CTAGCACTAATGGCACGTTTAAA	AATTAGAGTGCTTTTAGTGCTTGTTTAGATTTTGAGCA
CTAGCACTAATAGCACGTTTAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025206.1\|WP_011375298.1\|1432482_1433040_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP025206.1\|WP_112234054.1\|1433278_1436800_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_CP025206.1\|WP_096584233.1\|1444111_1444990_+\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NZ_CP025206.1\|WP_011375300.1\|1430779_1431199_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP025206.1\|WP_011375288.1\|1445073_1446060_+\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_CP025206.1\|WP_011375295.1\|1438429_1438696_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP025206.1\|WP_011375299.1\|1431274_1432252_-\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|178836
NZ_CP025206.1\|WP_016265616.1\|1428739_1430119_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|341130
NZ_CP025206.1\|WP_016265620.1\|1424892_1426035_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NZ_CP025206.1\|WP_112234055.1\|1439889_1441269_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NZ_CP025206.1\|WP_011375302.1\|1427877_1428558_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341358
NZ_CP025206.1\|WP_016265613.1\|1438841_1439240_+\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|368217
NZ_CP025206.1\|WP_016265618.1\|1426397_1426763_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP025206.1\|WP_025015946.1\|1436836_1438420_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NZ_CP025206.1\|WP_016265610.1\|1441942_1444039_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NZ_CP025206.1\|WP_016265617.1\|1426909_1427431_+\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|227052
NZ_CP025206.1\|WP_011375293.1\|1439360_1439804_+\|RNA-binding-protein-S1	unknown	unknown	gnl\|CDD\|236305
NZ_CP025206.1\|WP_011375291.1\|1441308_1441854_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP025206.1\|WP_016265619.1\|1426116_1426383_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025206.1\|WP_011375307.1\|1424535_1424889_+\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|234610

Protein	Function_ID	Function_description	E-value
NZ_CP025206.1\|WP_011375298.1\|1432482_1433040_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	7.65427e-102
NZ_CP025206.1\|WP_112234054.1\|1433278_1436800_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_CP025206.1\|WP_096584233.1\|1444111_1444990_+\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	4.18995e-153
NZ_CP025206.1\|WP_011375300.1\|1430779_1431199_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.34943e-17
NZ_CP025206.1\|WP_011375288.1\|1445073_1446060_+\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	2.77715e-138
NZ_CP025206.1\|WP_011375295.1\|1438429_1438696_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	3.11298e-27
NZ_CP025206.1\|WP_011375299.1\|1431274_1432252_-\|L-lactate-dehydrogenase	gnl\|CDD\|178836	PRK00066, ldh, L-lactate dehydrogenase; Reviewed.	0
NZ_CP025206.1\|WP_016265616.1\|1428739_1430119_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.38808e-30
NZ_CP025206.1\|WP_016265620.1\|1424892_1426035_+\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	8.21061e-150
NZ_CP025206.1\|WP_112234055.1\|1439889_1441269_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	1.09743e-71
NZ_CP025206.1\|WP_011375302.1\|1427877_1428558_-\|CBS-domain-containing-protein	gnl\|CDD\|341358	cd02205, CBS_pair_SF, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	4.64625e-11
NZ_CP025206.1\|WP_016265613.1\|1438841_1439240_+\|septum-formation-initiator-family-protein	gnl\|CDD\|368217	pfam04977, DivIC, Septum formation initiator. DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.	8.33573e-07
NZ_CP025206.1\|WP_016265618.1\|1426397_1426763_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.23272e-37
NZ_CP025206.1\|WP_025015946.1\|1436836_1438420_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.05663e-131
NZ_CP025206.1\|WP_016265610.1\|1441942_1444039_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP025206.1\|WP_016265617.1\|1426909_1427431_+\|QueT-transporter-family-protein	gnl\|CDD\|227052	COG4708, COG4708, Predicted membrane protein [Function unknown].	1.71362e-28
NZ_CP025206.1\|WP_011375293.1\|1439360_1439804_+\|RNA-binding-protein-S1	gnl\|CDD\|236305	PRK08582, PRK08582, RNA-binding protein S1.	2.95316e-74
NZ_CP025206.1\|WP_011375291.1\|1441308_1441854_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	8.61134e-90
NZ_CP025206.1\|WP_011375307.1\|1424535_1424889_+\|holo-ACP-synthase	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	1.06907e-45

>NZ_CP025206.1|WP_011375298.1|1432482_1433040_+|aminoacyl-tRNA-hydrolase
MKMIVGLGNPGSKYAKTKHNIGFMVIDQLCEKYNVTLNKHDFEAEYGSFKYEGETVLLVKPLTFMNDSGRSVGPLMSYYQVGIDELLVIQDDMDLTMGKLRLRQKGSAGGHNGIKSIIAHTKSQTFKRLKIGIQHPQKSTVVNWVLTPFDKDGAPVINQAIDQACEAIDDWCQNDDFMKTMNKFN
>NZ_CP025206.1|WP_011375299.1|1431274_1432252_-|L-lactate-dehydrogenase
MANIEKDHQKVILVGDGAVGSSYAYALTLQGIAQEVGIVDIFKEKTQGDAIDLSDALAFTSPKKIYAAEYSDAKDADVVVITAGAPQKPGETRLDLVSKNLKILKTIVDPIVESGFNGIFLVAANPVDILTYATWKLSGFPKERVIGSGTSLDSARFRKDIAEMVNVDARSVHAYIMGEHGDTEFPVWSHANIGGIKISEWVKAHPEVKEEELVKIFESVRDAAYTIINLKGATFYGIGTALARITKAILDDENAVLPLSVFMDGQYGLNDIFIGSPAVINRSGITNILEIPLTDHEMESMHKSAKQLKDIVTKAFEELDIETRQ
>NZ_CP025206.1|WP_011375300.1|1430779_1431199_+|MarR-family-transcriptional-regulator
MVGKADTRMQLLGEWYSKLQQIATKLNAISRKYDVSFEQFLVIEQIIEEERKSPSELAVFFKTSLPAVSRKLNLLQSKRLVYKIRGEQDDQRLMRVNATPEGIETYESIKAELLTWDAQLKDHDINLMAMVNHTLEHAN
>NZ_CP025206.1|WP_016265616.1|1428739_1430119_-|L,D-transpeptidase-family-protein
MKVSKKAYTALGVAAVILIGGYSAMSLHYNKVFLPNTVVAGTNISGKSPAEANEALLKQVNHQKFTLKEDQTTRLSFTAKDAGFSHNFQPLLKKIQSSQNGWSWLGHQLSNPKKLQSENALILNQQTFKQFANQTVTKLNTGRTASKNATIKLVNENFEIVKEVNGNQIDQAQFEKTINKAINQGKTSIDLKQDYTVPTIKSTDSALQKTAKKMTTISDEKIHYSVNGNEFTVPKATIQGWLVNNNGAVSLDKTAVSNYVYQLKTKYDTYDKPLTFKSTKQGTVTVPAGIYGWSISPADEISALMKEVPEGKDFSRTAVIRGSGMAQKDRSVGSTYIEIDKKAQHMWLYQNGKVTIQTDVVTARPPQTTPSGVWSIWKKERNATLKGTNFDGVSEYASPVNYWMPIDETGVGIHDSPWQPKYGGTWYKEHGSHGCINTPPTIMAQLYNTVSEGIPVVVI
>NZ_CP025206.1|WP_011375302.1|1427877_1428558_-|CBS-domain-containing-protein
MLIKSLVLPKERLTTIEESVTLEEALTILEDSGYRCVPVLDASGKIFRGNIYKMHIYRHKSQGGDMQLPVTSLLKNMTKYIPVDAPFFKVFFNIKDLPYIAVLDEDSNFFGILTHSTLLNMLSEAWNLELSSYVLTVLSAGEQGDLVAMSKIIAKYTSIASCMTLDAKQDEFVRRTLFTLPSGLDIEILKKITNKLEKKGFKVPEIDDLQSGKVLRNDSDEIENVI
>NZ_CP025206.1|WP_016265617.1|1426909_1427431_+|QueT-transporter-family-protein
MTNQNHLRSVILNGLVAALYVVLSLFPGVLGLASSPIQFRVSEGLNHLVVFNKKYLWGVFGGVLVFNFFFSSENKILDTLFGGGQTLLALLVLTLVIPHLKKTWQKMLVNIILFTVSMFMIAWMIVLTGSTAKTQIPFWPTYATLAISEAVIMTITAPIMYAVDQVLHFERQI
>NZ_CP025206.1|WP_016265618.1|1426397_1426763_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MGELIQRGDIYYADLSPVVGSEQGGMRPVLIIQNDVGNHHSPTVIVAAITAKIQKPKLPTHVGITAKANGVERDSVILLEQVRTIDKQRLKDKVTHLVAEKMRQVDRALTISVGLQPVLNP
>NZ_CP025206.1|WP_016265619.1|1426116_1426383_+|hypothetical-protein
MEANHERLSVNLDVKLVQEIKTYCEVYGLDENDLIQDAIHEFMATRQAKVDNVINGYVEMANLNSQIAAEFNACESEAYARIRTVDLS
>NZ_CP025206.1|WP_016265620.1|1424892_1426035_+|alanine-racemase
MTVGYLRPTRILVDQNAIYENIQNELKHLEGTDTVIFPVLKANAYGHGLIPVAEAAQAAGAAGFCVALLDEALALRRANFTEPILVLGITQPSEIELAAANQISLTVGSLEWLQEAAAIAQQVPYLHPVPIHLSIDSGMGRIGMRDEAELLAAYTFIKAHSDYFDFEGVFTHFATADDPDDTYFKEQSARFNQLMTALPERPRFVHVSNSATSLWHAACNGNIIRMGISLYGLNPSGNAIPDLPYPLKPALGIESELVFVKQVAAGTKIGYGATYEASEGEWIGTIPMGYADGWLRRMQGSTVLVDGQRCEIVGRICMDQMMIRLPKRYPVGTKVVFVGKSGDDEITLQEVADYADTIHYEIICDLSDRIPRVYTGLNEH
>NZ_CP025206.1|WP_011375307.1|1424535_1424889_+|holo-ACP-synthase
MIVGLGIDLAEIDRFEKAQEKNSRFAEKVLTATEFELFSHYTGRRALEFLAGRFAVKEAFSKAYGTGIGQVKLQAVETLNDPQGKPYIKQDLFDGVVHVSLSHTATLVIAEVILERG
>NZ_CP025206.1|WP_112234054.1|1433278_1436800_+|transcription-repair-coupling-factor
MDLISMLGNTQQVQSVLENQKPGVRQLLTGLSGSAKTLFLATIYKQQRQPLLIIESNMFQANQVAEDLANQLNGDQIYTFPVEEVMAAEIAVSSPESRAERVRTLSFLATGKKGIVVTSVAGMRRLLPTARQWRDSQTQIEMGGEVDPKILGAQLAEMGYHRDKLVGKPGEFAMRGDIIDIFPLDTENPVRIELFDTEVDAIRSFEADTQRSIENLESVAIMPATDLLANAAQLEMAGEALQADYQQTAAKITAKDDQKALAVNFETPISRLLAGERLENLALFVDYLYPDHTSLIDYFKNSGLVVFDDYPRIQETQRVLAEEAANWQTDMLGNRRLLPAQKLLVDVHHLMKQDQHPHLYLSLFQKGMGKLKLDTLGNMPTRNVQQFFSQMPLLKTEMSRWQKQQQTVVVLVSDAKRVKKIDQTFHDFEIEATVTTKTKLVAGQIQIVQGSLQNGFELPDLKLVVLTEKELFNTAPKKKVRRQTLANTERLKSYSELKPGDYVVHVNHGIGEYVGMETLEVDGVHQDYITILYRDNGKLFIPVTQLDMVQKYVSAESKTPKINKLGGAEWQKTKSKVSAKIEDIADDLIELYAQREAEKGYAFPEDDQLQADFENQFAYPETDDQLRSTAEIKHDMEKVRPMDRLLVGDVGFGKTEVALRAAFKAVAAGKQVAFLVPTTILAQQHYENMLARFADFPVELGLLSRFKTRKEVTATLKGLEKGQVDIVIGTHRLLSKDVVFKDLGLLIVDEEQRFGVKHKERLKQLKAQVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPTNRYPIQTYVMEQNAGAMREAIERELERNGQVFYLHNRVSDIEQTVDEIQALVPEATVGYAHGQMTEAQLEGVIYDFVQGKYDVLVTTTIIETGVDMPNVNTMIVEDADHYGLSQLYQLRGRIGRSSRVAYGYFMYKPDKVLTEVSEKRLQAIKDFTELGSGFKIAMRDLSIRGAGNLLGKQQHGFIDSVGFDLYSQMLSEAVAKKQGKKVAAKTNAEIDLKLEAYLPDDYINDQRQKIEIYKRIRQMDTEAAFTEIQSDLIDRFGDYPVQVAHLLTIGQLKMNADDALIETIKQVKDKIQVVLSPKGSRLVSGEQIFEALSATRLKATVGFEQEKLSVTLIIQPKMKTGDWLRELAIFVETLVEIEKKQLAK
>NZ_CP025206.1|WP_025015946.1|1436836_1438420_+|polysaccharide-biosynthesis-protein
MQNKQMQHLMKGAVVLSIASFVAKILSAVYRIPFQNMVGNTGFYVYQQVYPIYGIGMTFALSGFPVYISKIVAEETAPAEQTQILRRSFALLGLFGALIFFYLQYQAPAIAVAMADAELAPLIRMVSYMFLLMPFLAVTRGYFQGIFNMIPTATSQVAEQLVRVVVIILAAWLSLKLHWSVYEMGTWAMSGAFFGGLVATVALLKPAEKAFVLRGTKPKGINLGAYRSLAKRLLIEGGSICLFASLIVLLQLVDSFTVKKGLVASGLTEDFAKNLKGIFDRGQPLVQLGLVISMAFSSTLIPSLSRARQQQQDHQFQQVAESLIHISLGLSAAATTGLMILMPQVNYLLFGDADGNKALVWYMLSIVIIALINACNSVLQSLDQFHKTTIALLIGLLVKVVINQWLVQHFQIVGASVGTVISLGVVLALILRQSPELVRDALDGQHFTGKLVLICGIMAVAVRFVVTVIQPSLVSRGQAVLGAGVGIAVGVPVFISLALAWQLFSIREWLTIPGGKQLLKLAQKLKR
>NZ_CP025206.1|WP_011375295.1|1438429_1438696_+|RNA-binding-S4-domain-containing-protein
MRLDKFLKVSRIIKRRSVAKEIADKGRILINDRQAKSSSNVVVGDKLEIGFGNKTMIVKITQIIETTKKSDAAEMYEILETKVAENFE
>NZ_CP025206.1|WP_016265613.1|1438841_1439240_+|septum-formation-initiator-family-protein
MSRKITQIENAYTKQQAAKQKVEQKSKRTRTVHKRRLLALGVIALILFSVCGVQILQTHHSLALIEKQTVVKKQSLKKAKAKEADLKVQVSQLHNDDYLAKYIRYKYYYSKKGETIYSLPQDKAPNLNEQQK
>NZ_CP025206.1|WP_011375293.1|1439360_1439804_+|RNA-binding-protein-S1
MAVEVGSKVPGKVTGITNFGAFVDLGEGKTGLVHISEVSDSYIKDIHDVLTVGDEVTVKVMSDQNGKIGLSIRKAVDQPKVQEHTRPQSSRPNNNRGGYRKPEHTSAPKKEGFDDLLSGFLKDSEDRLSTIKRNTEGKRGGRGGRRS
>NZ_CP025206.1|WP_112234055.1|1439889_1441269_+|tRNA-lysidine(34)-synthetase-TilS
MLERAFQNEMRRHHFWPAGAKVIVATSTGVDSMVLVTLLQRLPTALKPQLIVAHVNHELRAESVAEEAYLRQFCLENDLALQVAHWPFKQHPQTGIEAAAREFRYQFFERLMTAEKVDYLVTAHHGDDQLETLMMKFIRSGELHEMRGIQSQRPFANGMLIRPLLPFAKQDLRDFASANNITSFEDQTNYETTVLRNRVRHTLVPFLKQENGQILQNANRFSQQLTALLGQQVQLTTTLLPLLDLKVTDKVISGQLKAIKTLPTAQQTAIWQLIIKQHFPQISPLKETQLQQLKQLIQSTVKPQGQLALGQRILFTKIYDRFQIGETTIGEIAAKDEKSRTLMLNKWCVLPNNEQIGIFEINHLPRKLSGQQLIWLADEQWPIVAKPCQLTDTIMIDKTHHKTLKRLFIDLKVPHEKRQNSWGIWAQETLVGYPEFRISALFNHEQTGKIRYVLCYISE
>NZ_CP025206.1|WP_011375291.1|1441308_1441854_+|hypoxanthine-phosphoribosyltransferase
MLEQDIERILYTREDIQRVNEKLGKQITADYQGKNPLMIGILKGAIVFMTDLIREIDLHVEIDFMDVSSYGDGTISSGEVKIIKDLDTSVQGRDIIIVEDIVDTGRTLNYLMAILKTRQANSIKVCTLMDKPSRRVVPVHSDYVGMEVPNEFVVGYGLDYAERYRNMGTIGVLKPEIYSGK
>NZ_CP025206.1|WP_016265610.1|1441942_1444039_+|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MNNKKNRLFSNSLFYIIILVALVGVFSFFMNGNSGSESKEVQSSTFLSELKTDKVKSFSIQPTNGIYKISGEYRKAQKDEQPKSTFFGSQSKNKKVTHFTTTLLQSDSQVSAITNLANQNKTKIETMQEPQSGWWVSILSLILPLIIMFGLFYMMMGQAGQGGGQGGRMMNFGKSKAQKADKGANKVRFSDVAGAEEEKQELVEVVEFLKDPRKFAALGARIPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKSAPSIIFIDEIDAVGRQRGAGMGGGHDEREQTLNQMLVEMDGFSGNEGVIVIAATNRSDVLDPALLRPGRFDRKILVGRPDVKGREAILKVHAKNKPLADDVDLKEIAQQTPGFVGADLENLLNEAALVAARRSKKDIDASDVDEAEDRVIAGPAKRDRVINPKERETVAYHEAGHAIIGLVLSDSRVVRKVTIVPRGRAGGYAIMLPKTDQFLMSKKELTEQMTGLMGGRTAEEIIFNSQSTGASNDFEQATDIARGMVTHYGMTEKLGTVALEKEGQPFVGAAYGQGPAFSEATAAAIDSEVRRLIDEAHQQATEIIQAHREQHKLIAEMLLKYETLNEKEILSLFNDGKMPEKNAEEFPSEKAATFEEAKKALEAKEAEKTDSELEAEQADSETTEVADDTADSKPTNDDSNDNA
>NZ_CP025206.1|WP_096584233.1|1444111_1444990_+|Hsp33-family-molecular-chaperone-HslO
MKDYLVKQVSEDGQLRAYAVNATQVVTEAQEKHDTWPTSSAAFGRTIVGTLLLSAAGLKGDTKMTVKVDGDGPVGKIVVDGNAQGTVKGYVTNPHVNLPSNEKNKIDVKAGVGTTGTLSVTKDLGLKEPFTGQVPLVSGELGEDFTYYLAKSEQTPSAVGVSVFVNEDSTIGVAGGFMIQILPGADDRLIDVLEARLQEMPLVSELLQQGMTPEEIITEIVGELPMKTLEELPVKYECDCSKERFAKALSSIAPQDLKQLIEEDHGAEATCRFCGKQYQFSEADLKAILAEQ
>NZ_CP025206.1|WP_011375288.1|1445073_1446060_+|tRNA-dihydrouridine-synthase-DusB
MTWQIGDVTIPNQVVVAPMAGITNAAFRVTAKEFGAGLVVCEMISDRGIMHNNKKTMGMMFVDPNEHPVSIQIFGGSKDTLVEAAKFVDQHTQADIIDINMGCPVNKVVKTDAGARWLLDPNKVYEMVSYVTDAVKKPVTVKMRTGWDEDHIFAVQNALAAERAGASALAMHGRTRKQMYTGKADWDILKQVKAELKIPFMGNGDVRTPQDAKRMLDEVGADAVMIGRAALGNPWILRQVETYLRSGELIAEPTPREKIATAKLQLHRLVELKGENVACREFRQQAAYYLKGIPRAAKTKAAVNEVETEQAVGDILDRFVEETEARMA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP025206_2	2.1\|1433161\|38\|NZ_CP025206\|CRISPRCasFinder	1433161-1433198	38	NZ_CP025206.1	1433035-1433072	0	1.0

1. spacer 2.1|1433161|38|NZ_CP025206|CRISPRCasFinder matches to position: 1433035-1433072, mismatch: 0, identity: 1.0

aattagagtgcttttagtgcttgtttagattttgagca	CRISPR spacer
aattagagtgcttttagtgcttgtttagattttgagca	Protospacer
**************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

94933 : 102329

Bacillus_virus(33.33%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016265164.1\|94933_95806_-	YitT family protein	M1Q1P6	Streptococcus_phage	4.8e-57	41.5
WP_035145825.1\|95953_97147_+\|tRNA	CCA tRNA nucleotidyltransferase	G3MAR3	Bacillus_virus	7.3e-32	36.1
WP_011374705.1\|97215_97677_+	hypothetical protein	NA	NA	NA	NA
WP_035145823.1\|97789_99679_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	2.3e-48	29.1
WP_016265161.1\|99825_100776_+	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	1.6e-122	64.3
WP_035145821.1\|100786_101287_+	dihydrofolate reductase	G3MBI7	Bacillus_virus	3.5e-28	38.7
WP_025015768.1\|101483_102329_+	DegV family protein	A0A0N9SI50	Staphylococcus_phage	7.7e-20	44.2

DBSCAN-SWA_2

438223 : 446517

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035146576.1\|438223_438793_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.4e-25	36.0
WP_094365686.1\|438789_439818_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.3e-64	44.3
WP_035146574.1\|439823_441257_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.9e-51	33.9
WP_035146572.1\|441232_443458_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.0e-151	41.1
WP_035146570.1\|443447_444134_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_016264839.1\|444130_444391_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_011374364.1\|444383_445109_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	4.1e-38	40.4
WP_035146568.1\|445221_446517_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.8e-15	30.6

DBSCAN-SWA_3

541590 : 551209

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025016310.1\|541590_542172_+	glycoside hydrolase family 73 protein	A0A0A7RUS8	Clostridium_phage	8.8e-23	44.0
WP_025016311.1\|542715_543300_+	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	1.5e-51	53.4
WP_035146459.1\|543524_544049_+	DsbA family protein	NA	NA	NA	NA
WP_035146456.1\|544163_544619_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_011374236.1\|544710_545655_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	2.3e-52	39.0
WP_035146453.1\|545657_546692_-	YvcK family protein	A1IMD5	Streptococcus_phage	3.4e-94	54.5
WP_011374234.1\|546688_547573_-	RNase adapter RapZ	A0A1P8D5W0	Corynebacterium_phage	8.4e-09	31.0
WP_016264747.1\|547698_548235_-	hypothetical protein	NA	NA	NA	NA
WP_016264746.1\|548356_551209_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	1.3e-305	54.9

DBSCAN-SWA_4

1556666 : 1563694

Enterobacteria_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076647914.1\|1556666_1557536_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	3.0e-99	59.7
WP_076647911.1\|1557548_1558130_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.1e-38	45.1
WP_112234078.1\|1558144_1559173_+	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	7.6e-70	43.0
WP_076647908.1\|1559229_1560075_+	dTDP-4-dehydrorhamnose reductase	I7HXC9	Enterobacteria_phage	3.6e-33	38.4
WP_076647905.1\|1560093_1560726_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.8e-51	51.7
WP_112234079.1\|1561028_1561577_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_085391519.1\|1561781_1562600_-	hypothetical protein	NA	NA	NA	NA
WP_056936491.1\|1562791_1563694_+	UTP--glucose-1-phosphate uridylyltransferase GalU	A0A127AW70	Bacillus_phage	4.2e-72	48.3

DBSCAN-SWA_5

1777810 : 1785920

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011374977.1\|1777810_1778137_-	heavy metal-binding domain-containing protein	M4STD1	Rhodobacter_phage	5.4e-06	34.6
WP_011374976.1\|1778153_1778519_-	DUF1304 domain-containing protein	NA	NA	NA	NA
WP_035146095.1\|1778604_1779597_-	UDP-glucose 4-epimerase GalE	A0A1V0SG19	Hokovirus	1.0e-47	36.6
WP_035146098.1\|1779741_1782054_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.9e-77	31.1
WP_011374973.1\|1782077_1782596_+	adenine phosphoribosyltransferase	A0A2K9L2N8	Tupanvirus	5.6e-13	32.2
WP_011374972.1\|1782730_1783345_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	1.1e-15	58.2
WP_035146102.1\|1783479_1783722_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_101377985.1\|1783802_1784033_+	YneF family protein	NA	NA	NA	NA
WP_112234093.1\|1784174_1785920_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	7.4e-49	30.1

DBSCAN-SWA_6

1877374 : 1889427

Enterococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016265287.1\|1877374_1878094_+	aquaporin family protein	M1HCP3	Acanthocystis_turfacea_Chlorella_virus	2.9e-28	34.1
WP_035146206.1\|1878437_1879811_+	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	3.0e-45	30.4
WP_035146208.1\|1879862_1880342_-	nucleoside 2-deoxyribosyltransferase	A0A1D3SPR3	Enterococcus_phage	3.8e-16	37.2
WP_035146212.1\|1880805_1882848_+	potassium transporter Kup	M1IAJ4	Acanthocystis_turfacea_Chlorella_virus	1.2e-69	35.5
WP_035147736.1\|1883090_1883789_+	LysM peptidoglycan-binding domain-containing protein	A0A288TY55	Enterococcus_phage	1.7e-17	46.4
WP_085391464.1\|1883815_1884190_+	hypothetical protein	NA	NA	NA	NA
WP_052039308.1\|1884209_1884455_+	hypothetical protein	NA	NA	NA	NA
WP_035147731.1\|1884454_1885759_+	Y-family DNA polymerase	Q6DMX4	Streptococcus_phage	1.3e-85	39.7
WP_035147729.1\|1885751_1886126_+	hypothetical protein	E3W8I0	Leuconostoc_phage	6.9e-05	32.7
WP_011374858.1\|1886353_1886605_+	hypothetical protein	NA	NA	NA	NA
WP_035147736.1\|1887273_1887972_+	LysM peptidoglycan-binding domain-containing protein	A0A288TY55	Enterococcus_phage	1.7e-17	46.4
WP_094365751.1\|1888055_1889427_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	4.6e-46	39.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP025207

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP025207_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP025207_1

34322-34472

Orphan

Consensus_repeat	Method
AAAGTAAACATGTATACATT	PILER-CR

2 spacers

csa3

The CRISPR arrays of NZ_CP025207_1

>merge|NZ_CP025207|1|34322-34472|PILER-CR
AATGTAAACATGTATACATTGGAAGGTACGATAAATATTTTGTTTACTTGTATTAATGTAAAAAAGTAAATATGTATACATTTTTACACATAATAATACCTATAAATAAGCAATACACAACTTTTAATACTAAAGTAAACATGTATACATT

>NZ_CP025207|1|1|34322-34472|PILER-CR
AATGTAAACATGTATACATT	GGAAGGTACGATAAATATTTTGTTTACTTGTATTAATGTAAA
AAAGTAAATATGTATACATT	TTTACACATAATAATACCTATAAATAAGCAATACACAACTTTTAATACT
AAAGTAAACATGTATACATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP025207.1\|WP_112234112.1\|20873_21461_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP025207.1\|WP_112234118.1\|29852_30716_-\|PRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|170086
NZ_CP025207.1\|WP_112234120.1\|41359_43036_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|163244
NZ_CP025207.1\|WP_016265853.1\|34547_35363_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379293
NZ_CP025207.1\|WP_076648299.1\|33000_33999_-\|replication-initiator-protein-A	unknown	unknown	gnl\|CDD\|369151
NZ_CP025207.1\|WP_100970100.1\|18544_20134_-\|asparagine-synthase-B	unknown	unknown	gnl\|CDD\|236513
NZ_CP025207.1\|WP_035147275.1\|40054_41350_+\|arsenic-transporter	unknown	unknown	gnl\|CDD\|185342
NZ_CP025207.1\|WP_112234113.1\|21708_23976_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|223256
NZ_CP025207.1\|WP_035147270.1\|37903_38272_+\|arsenite-efflux-transporter-metallochaperone-ArsD	unknown	unknown	gnl\|CDD\|377741
NZ_CP025207.1\|WP_035147263.1\|35924_36761_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025207.1\|WP_035147272.1\|38296_40006_+\|arsenical-pump-driving-ATPase	unknown	unknown	gnl\|CDD\|275109
NZ_CP025207.1\|WP_112234114.1\|24550_25444_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP025207.1\|WP_112234115.1\|25440_26115_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225511
NZ_CP025207.1\|WP_035147266.1\|36774_37368_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP025207.1\|WP_112234117.1\|27982_29863_-\|PTS-beta-glucoside-transporter-subunit-IIBCA	unknown	unknown	gnl\|CDD\|273919
NZ_CP025207.1\|WP_035145350.1\|35355_35706_+\|DUF5388-domain-containing-protein	unknown	unknown	gnl\|CDD\|375154
NZ_CP025207.1\|WP_112234116.1\|26480_27986_-\|glycoside-hydrolase-family-1-protein	unknown	unknown	gnl\|CDD\|225343
NZ_CP025207.1\|WP_035147269.1\|37551_37836_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP025207.1\|WP_112234121.1\|43311_43995_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP025207.1\|WP_099770434.1\|17933_18152_+\|putative-holin-like-toxin	unknown	unknown	gnl\|CDD\|319017

Protein	Function_ID	Function_description	E-value
NZ_CP025207.1\|WP_112234112.1\|20873_21461_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	2.04342e-45
NZ_CP025207.1\|WP_112234118.1\|29852_30716_-\|PRD-domain-containing-protein	gnl\|CDD\|170086	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional.	1.49482e-55
NZ_CP025207.1\|WP_112234120.1\|41359_43036_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|163244	TIGR03385, Coenzyme_A_disulfide_reductase, CoA-disulfide reductase. Members of this protein family are CoA-disulfide reductase (EC 1.8.1.14), as characterized in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi, and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. [Cellular processes, Detoxification].	1.62291e-124
NZ_CP025207.1\|WP_016265853.1\|34547_35363_+\|AAA-family-ATPase	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	4.14334e-51
NZ_CP025207.1\|WP_076648299.1\|33000_33999_-\|replication-initiator-protein-A	gnl\|CDD\|369151	pfam06970, RepA_N, Replication initiator protein A (RepA) N-terminus. This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included.	4.10292e-29
NZ_CP025207.1\|WP_100970100.1\|18544_20134_-\|asparagine-synthase-B	gnl\|CDD\|236513	PRK09431, asnB, asparagine synthetase B; Provisional.	0
NZ_CP025207.1\|WP_035147275.1\|40054_41350_+\|arsenic-transporter	gnl\|CDD\|185342	PRK15445, PRK15445, arsenical efflux pump membrane protein ArsB.	0
NZ_CP025207.1\|WP_112234113.1\|21708_23976_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
NZ_CP025207.1\|WP_035147270.1\|37903_38272_+\|arsenite-efflux-transporter-metallochaperone-ArsD	gnl\|CDD\|377741	pfam06953, ArsD, Arsenical resistance operon trans-acting repressor ArsD. This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)-Cys(113), that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs.	4.92215e-38
NZ_CP025207.1\|WP_035147272.1\|38296_40006_+\|arsenical-pump-driving-ATPase	gnl\|CDD\|275109	TIGR04291, Arsenical_pump-driving_ATPase, arsenical pump-driving ATPase. The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).	0
NZ_CP025207.1\|WP_112234114.1\|24550_25444_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.40057e-29
NZ_CP025207.1\|WP_112234115.1\|25440_26115_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	0.000142011
NZ_CP025207.1\|WP_035147266.1\|36774_37368_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	5.87885e-47
NZ_CP025207.1\|WP_112234117.1\|27982_29863_-\|PTS-beta-glucoside-transporter-subunit-IIBCA	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	0
NZ_CP025207.1\|WP_035145350.1\|35355_35706_+\|DUF5388-domain-containing-protein	gnl\|CDD\|375154	pfam17363, DUF5388, Family of unknown function (DUF5388). This is a family of unknown function found in Lactobacillales.	5.187e-25
NZ_CP025207.1\|WP_112234116.1\|26480_27986_-\|glycoside-hydrolase-family-1-protein	gnl\|CDD\|225343	COG2723, BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism].	2.17269e-167
NZ_CP025207.1\|WP_035147269.1\|37551_37836_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.83093e-20
NZ_CP025207.1\|WP_099770434.1\|17933_18152_+\|putative-holin-like-toxin	gnl\|CDD\|319017	pfam16935, Hol_Tox, Putative Holin-like Toxin (Hol-Tox). Hol_Tox is a family of small proteins (34-48aas) with a single TM region. Members can exhibit antibacterial activity against Gram-positive bacteria but not against Gram-negative bacteria.	1.99114e-06

>NZ_CP025207.1|WP_076648299.1|33000_33999_-|replication-initiator-protein-A
MDNQLNYYNIKREYALKFFQVPKVFMTNDKYKKLSAEAKLAFAILSDRLQLSIKNHWFDKAGNIYFIYTGEQLEQILGCGHSKITSIKKELTEAQLLVMKRMGQGKANRMYLLGPEITDNDIYGIDQLETAENPLAEEVVNIDLPTSMNDGQPETLDKSRLLKNSNLDYRKTVTSDTDINNTEYLKTLNTDTKKTDTLTDSPQNIKQLQDAALFEVQLENDNIFSKQQLLALKLLSNGDFELFCTVQKTILRAKKQALNSHQIQSSLFDLQDEDIDQPVYDALMRIVQQVRLGAIQDLNSYVFSTMFDQFEQLGSKRAITAYKTSGATITWE
>NZ_CP025207.1|WP_112234118.1|29852_30716_-|PRD-domain-containing-protein
MKIKKILNNNAFITHTDDHQELIVIGKAVAYGKHVNEEVDESKIYKTFAPVSRGDRKLILDMINDIPIQFFQIAKRIVDKAQADDQIDLTDSVYIALTDHIASAVDRAKEHLFLTNQFIWEIRSFYPKEFSIGLWALQLIEQRCGVPLPEDEAGFIAIHIISGELGNRLDDFQAVVNFIKKLTSIVTYQLAIDIDRESLDYNRFVTHLKFFWQYMMYNNEKQSIGDLSNDMLAIIKGKKVAAYECALKIKTFIHQTYNYDLSNEDLLYMTIHIARITENTGRQHDEV
>NZ_CP025207.1|WP_112234117.1|27982_29863_-|PTS-beta-glucoside-transporter-subunit-IIBCA
MKYEAMNQAIIKGVGGPGNVKSVVHCATRLRFVLNDESKADDDAVKNIPGILQLVKKVGQYQLVIGNNVEDVYNELADMLDLDNQATTADSGKDNRNLFDKVIGTITGSIAPAIPLLAGAGMGKVLLLILTLTGVLSDKSQTYQMLNLIFDTGYFFMPAFIGFSAAKIFKTNQYLGAFMGLVTVNPNWTALVAAAKPVSFIGIPVQLVSYSSTLITAILAVWIMSYIEKFVKRITPGMIKVFAEPMFIMLITAPLTFIVLGPTANLISMGIASVSMFLYQHAGFIAIPLLAAAYPWLVSIGIHKALSPISIQLVATQGFDPIIRVVALCSNMSQAAASLAVGLKTKNKELRALALSSSMTAYLGGITEPAMFGVNLKLKKPMYGAMIGGAVAGLFAGIMKMKAFIYVTPGLLSLPMWISKSENYVMLAVITILISTIATFIATWLIGFDDPVSQETVNQQTAVANQKMTEKHAINSPVAGEVRMLNEVNDETFSSGVMGNGIAVVPSEGRVVAPTDGLVSAVFETSHAIGIHLDNDADLLIHVGIDTVELKGQYFKTLVQKGQRFTAGQDLLQFDLDGIRSAGYDPTVMMIVLNTKDFLEVLPIPEDDQQVTVDNEILMLAQRRQS
>NZ_CP025207.1|WP_112234116.1|26480_27986_-|glycoside-hydrolase-family-1-protein
MKTYQTPSQFMWGVATAANQVEGGWNLDGKGRSIADCLRYRPEIDAKDYKAVNDMSSREIQLAVADQSTKGWAKRHGVDFYHRFREDIRTLAATGINTYRFSISWARIFPNGDDAQPNQAGLDYYLAVVQELKKYNITPIVTLSHYEMPLNLVLNYDAWFDPQVIGYFNKFAQTVIDYLHDDVKYWIPINEIDSIIRHPFSSAGLVADRFQGQNFEAVIYQAMHHQFLAAAKVVQYCHQRYADLQVGSMITRTMVYPYNSDPQNVLAATETMRDVYAFSDIQVRGRYPQYLLTTLKRKGIPLTISAEDRALLQQNTADFVAFSYYSSICTAADPTGLKVTKANRTAGVYNRYLPESEWGWQIDPVGLRLSLIDLYDRYQKPLFIVENGLGATDTLTADHHVHDQYRIDYLRQHIQQLLISMAEDGIELMGYCMWGSTDMISASSNQMSKRYGLVYVDLDDAGNGTYSRYRKDSYYWYQQLLSYGHQIPVEFLATPVPAVSE
>NZ_CP025207.1|WP_112234115.1|25440_26115_-|helix-turn-helix-domain-containing-protein
MPRARHTLQEKLALLAEFKQSGLSIGTFTRQHGIHRETLMRWQSRLERDGLAGLTEAHTNNHYSNELKLKAVQAFLAGEGSLLDLATKFGLRSSTQLDNWVSRYNRDKTLTARPSRKRVPTMSRQTTFEERIKIVEYVTKAKHSYTEAADHFQVSYQQVRTRVIKTKSGGYEALVDNRGHRKVNHELTELDKANLQIRELKAQLADKELYEAFIKKFQELQRRG
>NZ_CP025207.1|WP_112234114.1|24550_25444_-|IS3-family-transposase
MNKPHRLAYHAIKVVSQGNHGAVTKLLTVIGVSRQAYHKGLRRQETTWEKHNKQLKTRTQYWFDFHHQGIGAGNLLTNLQADKLIDFPVTLKQVRRVMRELDIRCQVRPKKHKRAKQAEQYLLDNVLKQNFQVTAPNKVWLSDSTELTYGLSGEYKVRLSGVLDLYGRRLLAYNLSATETSAAEIQVFQRAFTAVGKVPSLIHTDRGSAYTSRAFNHFINQFEITRSMSRPGTPYDNAPMERWWNEFKLRWMARHPRAKTYQELITLVESGIEYFNHDNRSAQRNGLTPDEYWNEAI
>NZ_CP025207.1|WP_112234113.1|21708_23976_+|excinuclease-ABC-subunit-UvrA
MTDLFADGTISIHGAQENNLKDVSLDIPKHKTTVFAGLSGSGKSSLVFDTLAAVSRRELNETFPSFTQQYLPKYGQPEVNRIDNLPVAIVVEQKPIGRNSRSTLATYTGIYSVLRLMFSRIGQPWVGYSEWFSFNLPQGMCPKCQGLGFVDDIDERQLIDPNKSLNEGAMTFAGFQPGTWRWKEYGNSGLFDLDKKIKDYTDEEYDLFMHAPQQKLKNPPANWGRTALYEGLVPRMLRSVIHSASGRHHEAALSKIVTRKPCPVCHGTRLNKKALTGKIAGKNIAEVSDMDLVSVLKFLDNISDPKAKTMVRELHSKVQALVNIGLGYLSLGRGTDTLSGGEAQRIKIAKYLTSSLSDLVYVLDEPSVGLHPHDIKLITQSLKKLKEHGNTIILVDHNPAIISTADYVVEMGPQAGKNGGQVTFTGTYDELLRSDTITGKMLREKITFQKPREPQSWLNVNHVTSHNLKDVSTRIPQGVMTVISGPAGSGKSTLVQAFKQQVSDQDYIDLSQDSVGLNIRSTPATYLNILNPLRKLFSKANNGVSTQLFSYNGKGACPRCKGKGVMITEMAFMDPIVQECELCHGKRYSQEALQYTYHGKDISEVLNLSINDTLEFFKDVPDIYKKVSLLHQVGLGYLNLSQSMTTLSGGEVQRVKLAMELNHTGRIYFLDEPTTGLHLQDTQQLIDLFEGLVDKGNTLILIEHNLKLISRADWLVDMGPDAGKFGGQVCFEGHPKDSLNDKNSRTGAALAAIIS
>NZ_CP025207.1|WP_112234112.1|20873_21461_-|recombinase-family-protein
MAKIGYARVSSKEQHLDRQLAALKDVDKLFTDKLSGANTNRPELQKMLAYIREGDIVLVTELDRLGRNNQDLTKIMNTIQNKGATLDVLNLPSMTGIADPNLRQLMTNLIIELYKYQAESERKRIIERQQQGIFLAKQQGKYHGRKPQYTEDDPRLLHAFKLYQTGMSDVDVARNTGIKRTTFIRYRKKCNIKRS
>NZ_CP025207.1|WP_100970100.1|18544_20134_-|asparagine-synthase-B
MCGFLAVDSKEFDLTTFCDALEKNVDRGPDMTETVEEDAVMFGFNRLAIMDLSDDGMQPFKGEDCTLVCNGEIYNFLQLKENVKDDFSFQSSSDCEVLIPLYRKYGLDTMCKMLDAEFAFVLYDKVAKKVVAGRDPIGIRPMFYGYTKEKGEIAFGSTAKTLMDLCDQIFPFPPGHYYDGEKFVTYRDPAMVTRMHTPSFEEATTGIRDYLVKGVEKRLHADAPVGYLLSGGLDSSLVCSIASKLMPGKKLRTFAIGMDRNPIDLKYAREVADYLGTDHTEFIMTRDDVLGALRKVIYTLETWDITTIRASIGMYLLCKKIHETTDLKVILTGECSDEIFGYKYTDYAPNAEAFQSESMKRVRELYMYDVLRADRCISANSLEGRVPFADLDFVEYVMSLDPDMKMNHYDKGKYLLRMAFAGQDYLPDDILMREKAAFSDAVGHSLVDDLKEYADAKYTDEDVAKASEKYAYKTPFTKESLLYRDIFEEFFPGKAEWIKDYWMPNSDWEGCDVDDPSARVLSNYGDSGK
>NZ_CP025207.1|WP_099770434.1|17933_18152_+|putative-holin-like-toxin
MVVNQVEKIRRWPLPSEGGDANGVLTRSIATPRKGVACMSVVDVLQLLLAFGNFIVDLLMLIVALIKLSAKK
>NZ_CP025207.1|WP_016265853.1|34547_35363_+|AAA-family-ATPase
MSSRVITFGNFKGGTGKTTTSTMVGIELARRNLKTLLVDLDPQGNATNLYLKTKENVDNEIVSFNKTLMAGIKDQDLSQTIINILPNLDVLPSSADFSLYPRFMETVSSDYNERVWYFSKLMKEFKEKYDYILIDIPPTISLITDSALYASDYCVIVLQTQERSLQGAEAFINYMQEQVIDTFKAPTLDLIGILPVLLKNGAPVDNSTLEVAKELFGSENIFDITIKNMERLKRYDVTGVMFKDQFDHAVQNVYEKVTTEMISRIGAIENG
>NZ_CP025207.1|WP_035145350.1|35355_35706_+|DUF5388-domain-containing-protein
MGSLLNSNRVKSNSLDRGKRIEPENSMSIKDLSNPGEQSKSSKIESVTYYANVRINNHIKNKAEALSIIGVAKSQKDAIDRALDSFVEQLSDDEKRSFKNQLATLEAKDVKMKSEK
>NZ_CP025207.1|WP_035147263.1|35924_36761_-|hypothetical-protein
MKLFRKKYKPFPTPENTPGYTNKKVFDNFITEASKILQDTRRSQTVDKTSIFVLLKHLTDLVTLETSFTAYDHSSTEFSDYLLQIFEVRNEHNAKKLFEEIYLNLELKDEDKKYYLGKFTSNTKYTPTLSTLPLVLFPWNYKRISSSIKYIANSNNPFSIEESNGNVINVYFYPLGIALCERGNHSQLSAKLKGVGETSIERIMNIEHVYDHVNYDGIYFYHIFSENEETNPYRFKAQNRTEFLAGIIFEIGRLLKNYPELFPEEIKFAINNKEKIKQ
>NZ_CP025207.1|WP_035147266.1|36774_37368_-|recombinase-family-protein
MVKIYGYARVSTSSQNLEEQVAQLVDAGVNPQNIYSEKFTGTTTHRPIFDLLLNTISNGDTLVITKLDRFARNTREALNSIEPLLEQNISIKVLNLGTIENTPMGKMIVRTLLSVAEMERDMIVERTQAGKEYSKKHNLNYREGRPRRRIGPHEQAIYEYYKNHSIKETIAAFNTSKATLFRIIHQIQIENLSTSER
>NZ_CP025207.1|WP_035147269.1|37551_37836_+|winged-helix-turn-helix-transcriptional-regulator
MNYTQLAKIFKALSDKNRVKIVDLLSAGEKCACDLLDQFEFSQPTLSHHMKVLIEANIVIARKSGKWQHYSLNVDFVDSFDEQIKSLLLEKIAN
>NZ_CP025207.1|WP_035147270.1|37903_38272_+|arsenite-efflux-transporter-metallochaperone-ArsD
MKKVELFEAALCCNTGVCGPSVDKNLMLMTAAFNTMVKNTDTFDAYRYNLNSTPDAFAQNPDILALIQQEGNAVLPILRVDNVIVKSGDYPTLAELSEFTGAYFVEQSSNACCGDNTTNCCE
>NZ_CP025207.1|WP_035147272.1|38296_40006_+|arsenical-pump-driving-ATPase
MNFNLYNPNEVLDTKYLFFTGKGGVGKTTSACATAIQLADNGRRVMLVSTDPASNLQDVFQRELTNQATQIEEVPGLSVANFDPVTAAEDYKESVIAPYRGVLPESAIENMAEQLSGSCTVEIAAFNEFANFLTSPDVANSFDTIIFDTAPTGHTLRLLQLPSAWSGYLDENQQGASCLGQLAGMGDRKAVYEKAMATLNDDTLTTLIMVTRPQLAPLLEADRASTELKNLGITNQKLILNGVFETATDAVSQIFYDRQQADLVRMPDTLNQLKSYQIPLRAYNIAGIDNVRNLLKKSQPITKITNNRDTNLPEFGLMIDDFVNTNKKLIFTMGKGGVGKTSIAIKIATELAKRGKRVHLASTDPADHISEILTDTTNIKLSHIDEAQELKHYQNEVIAKAALTMSPADVDYVKEDLQSPCTQEIAVFRAFAELVADDDCDIAVIDTAPTGHTLLLLDSSQSYAKEVERTSGDVPESIVNLLPKLQDARQTEVVMVTLPETTPVYESMRLADDLDRANMAHSWWVINQSLLATHTNNPILASRANNETAWINKVDQLSAGQYNVISWQA
>NZ_CP025207.1|WP_035147275.1|40054_41350_+|arsenic-transporter
MQVTFAVSIFLLTLLFVIWQPKGLSIGWSAMVGAGLALLFRVVTLKDVWTVTGIVWNATLSFIAIIMISLILDKVGFFEWCALHMARIADGHGIRMFVLISVLGAFVSALFANDGAALILTPIVLAMVRALNFDEKKVFPFIIASGFIADATSLPLVVSNLVNIVSADFFGISFSTYALHMLIPTLFSLVASIIVLYLYFRKALPRHYDVSQVADPKTAITDLFLFKFSWIVLITLLAGYFIGSFLKIPVSFIAITIAAIFLLVANRSAVIETKAIIKGAPWNIVFFSIGMYVVVYGLQNAGITTLIASAITYIAQKGLFIGTVGMGFIAAILSSLMNNMPTVMINALSIDQVQASELVHKGLIYANVIGSDLGPKITPIGSLATLLWLHVLAQKNVKISWGQYFKIGITITIPVLFITLCGLYLSLLLLG
>NZ_CP025207.1|WP_112234120.1|41359_43036_+|FAD-dependent-oxidoreductase
MKIVVIGSVAAGTSVAAKARRNNEKNEITVYEKGKDISYSVCGMPFYLGGEISDLETLIPRDTNWFKKRFNVDIFVGIEVVSIDEVNQKLRLKNLTTGELFEDYYDKLVLATGATPRIIAPFNLNYQNMFTMHNMADTRAIDNYLKTNSCQNVVIFGTGYVGLEMMEQLKHRGLNVTLIQRSSQIMTNYDGEMAYRAELIILENGVNIIKNVTTKKIIEKDDIIHTIVLNDGTQIPTDLVILATGVVPQTSLVDHINIAKGPSGALKVSADMATSIPNIYAVGDIAESFSVIDGSPLYRPMGSTANKMGRIAGDAITGGQLRHRGVLGTGIVRLFDVTVAQTGFTEKIANAKGYDVEVLYNIKPGHADYLNGTENIIKAIADKKTGKLLGVQIIGKDGVDKRIDVFATAMSFGATVSDLFHLDLAYQPLYATTKDPVLYTGMALDNALNGRRLLTPTKLYQLLQDGQKIQIIDVRSKKQYDQQHIDSAISMPLGDIRKRISELDKNILTVTYCNKGVTGNAAQNLLINLGFANVYNLSGGHKNYKMVVNYIKYSKIKH
>NZ_CP025207.1|WP_112234121.1|43311_43995_-|hypothetical-protein
MKRLIGVFSVILVSTVVLVGCQNNQNTNKEKTQTSVTKKKVKSSSSSKTSSEISQSKEEAEKDSKIEEDIASRNEASEEKERKEEKTYLMSNDDVDFFLDGFSSDYTAMANYLDELISALKTKDNNPDLLNIISSWIENTQYTDFNRVEFGVSLDIQNKVRDIMYINKELVTDYSSMNNEAKKAMDSKTYEMSPEFTQAYADYQVTIKKAINQIAQLKTFMEQEDDE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	NZ_AP017932	Lactobacillus sakei strain LK-145 plasmid pLs145-a, complete sequence	21897-21938	0	1.0
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	NZ_CP025207	Lactobacillus sakei strain WiKim0074 plasmid pLSW74_1, complete sequence	34342-34383	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	NZ_AP017932	Lactobacillus sakei strain LK-145 plasmid pLs145-a, complete sequence	21959-22007	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	NZ_CP025207	Lactobacillus sakei strain WiKim0074 plasmid pLSW74_1, complete sequence	34404-34452	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	NZ_CP022710	Lactobacillus sakei strain WiKim0063 plasmid pLBS01, complete sequence	60855-60903	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	NZ_KF559312	Lactobacillus sakei strain KCA311 plasmid pKCA54, complete sequence	45044-45092	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	NZ_LT960778	Lactobacillus sakei strain FLEC01 plasmid 2, complete sequence	1369-1417	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	NZ_LT960782	Lactobacillus sakei strain J64 plasmid 2, complete sequence	1369-1417	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	NZ_LT907987	Lactobacillus sakei strain T332 plasmid p332A2, complete sequence	1369-1417	0	1.0
NZ_CP025207_1	1.2\|34404\|49\|NZ_CP025207\|PILER-CR	34404-34452	49	AP018700	Lactobacillus curvatus NFH-Km12 plasmid NFH-Km12_plasmid1 DNA, complete genome	35484-35532	0	1.0
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	NZ_KF559312	Lactobacillus sakei strain KCA311 plasmid pKCA54, complete sequence	45113-45154	1	0.976
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	NZ_LT960778	Lactobacillus sakei strain FLEC01 plasmid 2, complete sequence	1438-1479	1	0.976
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	NZ_LT907987	Lactobacillus sakei strain T332 plasmid p332A2, complete sequence	1438-1479	1	0.976
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	AP018700	Lactobacillus curvatus NFH-Km12 plasmid NFH-Km12_plasmid1 DNA, complete genome	35553-35594	1	0.976
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	NZ_CP022710	Lactobacillus sakei strain WiKim0063 plasmid pLBS01, complete sequence	60793-60834	1	0.976
NZ_CP025207_1	1.1\|34342\|42\|NZ_CP025207\|PILER-CR	34342-34383	42	NZ_LT960782	Lactobacillus sakei strain J64 plasmid 2, complete sequence	1438-1479	2	0.952

1. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to NZ_AP017932 (Lactobacillus sakei strain LK-145 plasmid pLs145-a, complete sequence) position: , mismatch: 0, identity: 1.0

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
ggaaggtacgataaatattttgtttacttgtattaatgtaaa	Protospacer
******************************************

2. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to NZ_CP025207 (Lactobacillus sakei strain WiKim0074 plasmid pLSW74_1, complete sequence) position: , mismatch: 0, identity: 1.0

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
ggaaggtacgataaatattttgtttacttgtattaatgtaaa	Protospacer
******************************************

3. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to NZ_AP017932 (Lactobacillus sakei strain LK-145 plasmid pLs145-a, complete sequence) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

4. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to NZ_CP025207 (Lactobacillus sakei strain WiKim0074 plasmid pLSW74_1, complete sequence) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

5. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to NZ_CP022710 (Lactobacillus sakei strain WiKim0063 plasmid pLBS01, complete sequence) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

6. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to NZ_KF559312 (Lactobacillus sakei strain KCA311 plasmid pKCA54, complete sequence) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

7. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to NZ_LT960778 (Lactobacillus sakei strain FLEC01 plasmid 2, complete sequence) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

8. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to NZ_LT960782 (Lactobacillus sakei strain J64 plasmid 2, complete sequence) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

9. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to NZ_LT907987 (Lactobacillus sakei strain T332 plasmid p332A2, complete sequence) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

10. spacer 1.2|34404|49|NZ_CP025207|PILER-CR matches to AP018700 (Lactobacillus curvatus NFH-Km12 plasmid NFH-Km12_plasmid1 DNA, complete genome) position: , mismatch: 0, identity: 1.0

tttacacataataatacctataaataagcaatacacaacttttaatact	CRISPR spacer
tttacacataataatacctataaataagcaatacacaacttttaatact	Protospacer
*************************************************

11. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to NZ_KF559312 (Lactobacillus sakei strain KCA311 plasmid pKCA54, complete sequence) position: , mismatch: 1, identity: 0.976

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
ggaaggcacgataaatattttgtttacttgtattaatgtaaa	Protospacer
******.***********************************

12. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to NZ_LT960778 (Lactobacillus sakei strain FLEC01 plasmid 2, complete sequence) position: , mismatch: 1, identity: 0.976

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
ggaaggcacgataaatattttgtttacttgtattaatgtaaa	Protospacer
******.***********************************

13. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to NZ_LT907987 (Lactobacillus sakei strain T332 plasmid p332A2, complete sequence) position: , mismatch: 1, identity: 0.976

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
ggaaggcacgataaatattttgtttacttgtattaatgtaaa	Protospacer
******.***********************************

14. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to AP018700 (Lactobacillus curvatus NFH-Km12 plasmid NFH-Km12_plasmid1 DNA, complete genome) position: , mismatch: 1, identity: 0.976

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
ggaaggcacgataaatattttgtttacttgtattaatgtaaa	Protospacer
******.***********************************

15. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to NZ_CP022710 (Lactobacillus sakei strain WiKim0063 plasmid pLBS01, complete sequence) position: , mismatch: 1, identity: 0.976

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
ggaaggcacgataaatattttgtttacttgtattaatgtaaa	Protospacer
******.***********************************

16. spacer 1.1|34342|42|NZ_CP025207|PILER-CR matches to NZ_LT960782 (Lactobacillus sakei strain J64 plasmid 2, complete sequence) position: , mismatch: 2, identity: 0.952

ggaaggtacgataaatattttgtttacttgtattaatgtaaa	CRISPR spacer
agaaggcacgataaatattttgtttacttgtattaatgtaaa	Protospacer
.*****.***********************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 27986

unidentified_phage(12.5%)

holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_112234110.1\|699_1167_+	DNA starvation/stationary phase protection protein	NA	NA	NA	NA
WP_025016531.1\|1627_2188_+	hypothetical protein	NA	NA	NA	NA
WP_025016530.1\|2245_2695_-	DUF305 domain-containing protein	A0A1V0SJW0	Klosneuvirus	2.0e-06	33.1
WP_035147929.1\|2806_3982_-\|transposase	IS256 family transposase	A0A0N9STL0	Staphylococcus_phage	8.2e-28	29.2
WP_003587210.1\|4307_4775_-	DNA starvation/stationary phase protection protein	NA	NA	NA	NA
WP_061827395.1\|5320_5965_+	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_008855846.1\|6090_6372_+	thioredoxin family protein	NA	NA	NA	NA
WP_015474701.1\|6385_6700_+	thioredoxin	A0A1J0GW78	Streptomyces_phage	2.0e-13	41.0
WP_006844823.1\|6720_7044_+	thioredoxin family protein	NA	NA	NA	NA
WP_080280589.1\|7043_7178_+	hypothetical protein	NA	NA	NA	NA
WP_006844822.1\|7262_8207_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	7.7e-77	47.9
WP_006844821.1\|8225_8873_+	DsbA family oxidoreductase	NA	NA	NA	NA
WP_015474696.1\|9034_10366_+	NAD(P)/FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	1.9e-20	24.7
WP_052039314.1\|10498_10759_-	hypothetical protein	NA	NA	NA	NA
WP_112234111.1\|10801_11731_-\|transposase	IS30 family transposase	H7BW47	unidentified_phage	1.1e-24	34.4
WP_016265840.1\|11871_12822_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A096XT60	Enterococcus_phage	3.2e-99	55.0
WP_099947808.1\|12836_13763_-	ribonucleoside-diphosphate reductase	A0A2H4P8A9	Corynebacterium_phage	2.9e-36	31.7
WP_025016512.1\|13869_16017_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	1.0e-254	60.2
WP_081394642.1\|16044_16497_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	NA	NA	NA	NA
WP_085391442.1\|16918_17848_+\|transposase	IS30-like element ISLpl1 family transposase	H7BW47	unidentified_phage	3.0e-25	34.8
WP_099770434.1\|17933_18152_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_100970100.1\|18544_20134_-	asparagine synthase B	L7RC73	Acanthamoeba_polyphaga_moumouvirus	7.3e-104	40.8
WP_112234112.1\|20873_21461_-	recombinase family protein	M9Q1K0	Clostridium_phage	3.5e-19	34.7
WP_112234113.1\|21708_23976_+	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	9.7e-126	30.9
WP_112234114.1\|24550_25444_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.1e-19	28.5
WP_112234115.1\|25440_26115_-	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	3.1e-27	32.9
WP_112234116.1\|26480_27986_-	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	7.6e-26	24.2

DBSCAN-SWA_2

34547 : 43036

Staphylococcus_phage(40.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016265853.1\|34547_35363_+	AAA family ATPase	F0PIG8	Enterococcus_phage	2.9e-56	45.5
WP_035145350.1\|35355_35706_+	DUF5388 domain-containing protein	NA	NA	NA	NA
WP_035147263.1\|35924_36761_-	hypothetical protein	NA	NA	NA	NA
WP_035147266.1\|36774_37368_-	recombinase family protein	A0A0A8WIK3	Clostridium_phage	3.3e-33	45.6
WP_035147269.1\|37551_37836_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.1e-17	54.4
WP_035147270.1\|37903_38272_+	arsenite efflux transporter metallochaperone ArsD	NA	NA	NA	NA
WP_035147272.1\|38296_40006_+	arsenical pump-driving ATPase	NA	NA	NA	NA
WP_035147275.1\|40054_41350_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	2.0e-147	64.8
WP_112234120.1\|41359_43036_+	FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	6.9e-12	24.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP025206

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP025207

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection