CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022744	Streptomyces lincolnensis strain LC-G chromosome, complete genome	5 crisprs	c2c9_V-U4,cas5,cas2,csa3,Cas14u_CAS-V,DEDDh,cas3,DinG,WYL,Cas9_archaeal,cas4	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022744_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022744_1

4191463-4191524

Orphan

Consensus_repeat	Method
CCGCCGGGAGGGCCGTAGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022744_1

>merge|NZ_CP022744|1|4191463-4191524|CRISPRCasFinder
CCGCCGGGAGGGCCGTAGCCGCCTCCCCAGCCGTTCTGACCGCCCGGTCCACCGGGGCCGCC

>NZ_CP022744|1|1|4191463-4191524|CRISPRCasFinder
CCGCCGGGAGGGCCGTAGCCGCC	TCCCCAGCCGTTCTGA
CCGCCCGGTCCACCGGGGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022744.1\|WP_170068302.1\|4173225_4175262_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|224218
NZ_CP022744.1\|WP_067433769.1\|4189612_4190431_-\|DUF4129-domain-containing-protein	unknown	unknown	gnl\|CDD\|379261
NZ_CP022744.1\|WP_067433756.1\|4195951_4197781_+\|GerMN-domain-containing-protein	unknown	unknown	gnl\|CDD\|237447
NZ_CP022744.1\|WP_187284748.1\|4193126_4193816_+\|two-component-system-response-regulator-MtrA	unknown	unknown	gnl\|CDD\|223816
NZ_CP022744.1\|WP_067433747.1\|4200421_4201168_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP022744.1\|WP_067433738.1\|4203342_4206180_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP022744.1\|WP_067433741.1\|4202490_4203072_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP022744.1\|WP_067433789.1\|4175809_4177267_+\|adenosylhomocysteinase	unknown	unknown	gnl\|CDD\|377487
NZ_CP022744.1\|WP_067433781.1\|4179297_4180305_+\|stage-II-sporulation-protein-M	unknown	unknown	gnl\|CDD\|376676
NZ_CP022744.1\|WP_067433752.1\|4198001_4199213_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_CP022744.1\|WP_067433772.1\|4188413_4189616_-\|DUF4350-domain-containing-protein	unknown	unknown	gnl\|CDD\|379527
NZ_CP022744.1\|WP_067433744.1\|4201208_4202381_-\|winged-helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225755
NZ_CP022744.1\|WP_067433750.1\|4199524_4200217_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|238308
NZ_CP022744.1\|WP_067433778.1\|4186114_4187425_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP022744.1\|WP_107406626.1\|4187424_4188414_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP022744.1\|WP_067433794.1\|4171381_4172362_+\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP022744.1\|WP_067433784.1\|4178135_4179167_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|224628
NZ_CP022744.1\|WP_067433763.1\|4191973_4193122_+\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|273112
NZ_CP022744.1\|WP_067433787.1\|4177479_4178094_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067433760.1\|4193817_4195962_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715

Protein	Function_ID	Function_description	E-value
NZ_CP022744.1\|WP_170068302.1\|4173225_4175262_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|224218	COG1299, FruA, Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism].	1.63705e-126
NZ_CP022744.1\|WP_067433769.1\|4189612_4190431_-\|DUF4129-domain-containing-protein	gnl\|CDD\|379261	pfam13559, DUF4129, Domain of unknown function (DUF4129). This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	2.83996e-06
NZ_CP022744.1\|WP_067433756.1\|4195951_4197781_+\|GerMN-domain-containing-protein	gnl\|CDD\|237447	PRK13613, PRK13613, lipoprotein LpqB; Provisional.	0
NZ_CP022744.1\|WP_187284748.1\|4193126_4193816_+\|two-component-system-response-regulator-MtrA	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.92317e-88
NZ_CP022744.1\|WP_067433744.1\|4201208_4202381_-\|winged-helix-turn-helix-domain-containing-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	1.47887e-74
NZ_CP022744.1\|WP_067433738.1\|4203342_4206180_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP022744.1\|WP_067433741.1\|4202490_4203072_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.03732e-28
NZ_CP022744.1\|WP_067433789.1\|4175809_4177267_+\|adenosylhomocysteinase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
NZ_CP022744.1\|WP_067433747.1\|4200421_4201168_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.60502e-78
NZ_CP022744.1\|WP_067433752.1\|4198001_4199213_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	2.99081e-14
NZ_CP022744.1\|WP_067433781.1\|4179297_4180305_+\|stage-II-sporulation-protein-M	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	5.76256e-44
NZ_CP022744.1\|WP_067433750.1\|4199524_4200217_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|238308	cd00552, RaiA, RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD).	7.47295e-26
NZ_CP022744.1\|WP_067433778.1\|4186114_4187425_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.52883e-49
NZ_CP022744.1\|WP_107406626.1\|4187424_4188414_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.99017e-102
NZ_CP022744.1\|WP_067433794.1\|4171381_4172362_+\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	8.17391e-38
NZ_CP022744.1\|WP_067433784.1\|4178135_4179167_-\|RDD-family-protein	gnl\|CDD\|224628	COG1714, COG1714, Predicted membrane protein/domain [Function unknown].	5.96156e-18
NZ_CP022744.1\|WP_067433763.1\|4191973_4193122_+\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|273112	TIGR00512, methylthioribose-1-phosphate_isomerase_predicted, S-methyl-5-thioribose-1-phosphate isomerase. The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family].	3.09502e-123
NZ_CP022744.1\|WP_067433772.1\|4188413_4189616_-\|DUF4350-domain-containing-protein	gnl\|CDD\|379527	pfam14258, DUF4350, Domain of unknown function (DUF4350). This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	5.0334e-08
NZ_CP022744.1\|WP_067433760.1\|4193817_4195962_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.19861e-57

>NZ_CP022744.1|WP_067433769.1|4189612_4190431_-|DUF4129-domain-containing-protein
MSLAGGVLTAVPALPHAAESAVRIVLRAGDASVRAVLRAADTVSVLSLARSDDAPPLTTPRDPAREAARRELTKRMYHENDPSLLQRALDAFWDWVGKLLGSASAATPGGPLGLVVVILIVIAVLGALWWRLGAPRREPTSAPALFDDRPRSAAEHRAAAEAHAAQGHWNQAVQERMRAIVRSLEERALLDTRPGRTADEAATEAGRTLPPQSDRLRTAARDFDDVTYGGRRASEQSYHRIAELDRDLERTKPQLANSSHSTAPNTRQGAAE
>NZ_CP022744.1|WP_067433772.1|4188413_4189616_-|DUF4350-domain-containing-protein
MTTEATLPSTSASPTARQVWTRARGVVLALVVLLAAAVAIAAIRSDARHGELDPRSADPYGSRAVAELLADRGVSTRVVTTLDEARAAAGPDTTLLVAVPDLLTERQQGRLYSATAESAGRTVLVAPGGTSVERLAPGIVAAPATSLDSTLSPGCDLAAARRAGTADTGGIRYTVTRPGADECYPSERLATLVRLPAESGNGDTVVLGAPDILFNNHLDEQGNASLALQLLGSRPHLVWYLPSLSDASAADPDDEKGFFDLLPSGWLWGTLQLFIAAGLAAFWRARRLGPLVPEKLPVAIRASESVEGRARLYRKANARDRAAAALRSTTRTRLAPLVGVPVTQAHAPEALLPALSAHLHTPGDGQTMHALLFGPPPSDDAALISLADQLDALEREVRRP
>NZ_CP022744.1|WP_107406626.1|4187424_4188414_-|MoxR-family-ATPase
MDPTTDNAGNTGDADTARASLEALRAEIAKAVVGQDPAVTGLVVALLCRGHVLLEGVPGVAKTLLVRALASALELDTKRVQFTPDLMPSDVTGSLVYDARTAEFSFQPGPVFTNLLLADEINRTPPKTQSSLLEAMEERQVTVDGTPRPLPDPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLTIPLPSRQDEIDVLTRHAEGFNPRDLHAAGVRPVAGPADLEAARAAVAKTTVSPEITAYVVDICRATRESPSLSLGVSPRGATALLATARAWAWLTGRDYVTPDDVKALALPTLRHRVQLRPEAEMEGVTPDSVINAILAHVPVPR
>NZ_CP022744.1|WP_067433778.1|4186114_4187425_-|DUF58-domain-containing-protein
MALTGRAALLAALGSLPVGIWDPSWTGILAVNAPLALACACDAALAAPVRRLGLTRSGDTSVRLGDTADVTLTVTNTSRRPLRAHLRDAWPPSSWQPGTEVEASRHHLTVPPGERRRTTTRLRPTRRGDRQADRVTIRSYGPLGLFSRQGTHKVPWTVRVLPPFTSRKHLPSKLARLRELDGRTSVLTRGEGTEFDSLREYVPGDDTRSIDWRATARQTTVAVRTWRPERDRHILLVLDTGRTSAGRVGDAPRLDASMDAALLLAALASRAGDRVDLLAYDRRVRALVQGRTAGDVLPSLVNAMASLEPELVETDSRGLTATALRSAPRRSLIVLLTSLDAAPVEEGLLPVLPQLTQRHTVLLASVADPHIARMARARGNSDAVYEAAAAAQAQSERHRTAEQLRRHGVTVVDATPDDLAPALADAYLALKSAGRL
>NZ_CP022744.1|WP_067433781.1|4179297_4180305_+|stage-II-sporulation-protein-M
MDLDVFVTAHRAEWDRLDALLRRQRRLTGTEVDELVALYQRTATHLSLIQSSAPDPQLTGRLSQLVARARSAVTGTRRASWRDVTRFLTHGFPAAVYRSRHWWVPTALLSTVVAALLGWWIGAHPDVQATIAAPDELRELTRPGGQYETYYSSHPAASFAAQVWTNNAQAAAMCLVLGIFLGLPVLWILFQNMLNLGVGFGLMSSAGRLDTFLGLILPHGLLELTAVFVAAGTGLRLGWTVIDPGPRSRRSALAEEGRAAVGMAIGLALVLFISGAIEGFVTPSGLPTWARIGIGILAELAFLAYVYVLGGRAVRAGDTGDVEEAERSAAVPTAA
>NZ_CP022744.1|WP_067433784.1|4178135_4179167_-|RDD-family-protein
MSELVTGEAVALELRPARLPSRALAVLIDLAVTITAYVVVTIVLVASTSSLDDAAQIALSIAAFLLVLVGGPIAVETLSHGRSLGKLACGLRVVRDDGGPIRFRHALVRGAIGTVEILMTFGVVATIASLVSARGRRLGDVFAGTLVVRERIPTARAGVVPPPPPWLAGRFSGLDLSAVPDGLWLAIRQYLTRMHQLDPRVGWTMAERLAGDLAARTGAPAPQGVPPAAYLAAVMQERQAREARRAFGGGAGGATAAGAPRGYGGPSNGAPGGYEPPSGGSAGVPQATGQDVAGVSPAVSPVGGSAEAPVDGRFGAPVPEAQPAVPRSTPSAERPGTGFVPPA
>NZ_CP022744.1|WP_067433787.1|4177479_4178094_+|hypothetical-protein
MPRGRYSLHDPHDHTPLAEEHFQCAPGPSGWRYVSQLTAPSGEHSGSVDLTLDELGRPLRLELHAASWQVRGAALDGVTWVRTDPSGTHATEGNVAAHAFTGTSPAFLIATTRLLRLTPSGPATRVRLVVFTDPVLAPRTVDQSWALLKREAHATDNGPLTVEEYQVTALDTGEQHTVHIAGDVVLAAPGIELENLDSPPSVFT
>NZ_CP022744.1|WP_067433789.1|4175809_4177267_+|adenosylhomocysteinase
MTTVENRHDFKVADLSLAEFGRKEITLAEHEMPGLMAIRKEYAEAQPLAGARVTGSLHMTVQTAVLIETLAALGAEVRWASCNIFSTQDHAAAAIAVGPNGTPDNPQGIPVFAWKGETLEEYWWCTEQALTWPNTPTGGPNMILDDGGDATMLVHKGVEYEKDGKVPDVETAESDEHRVVLELLTRTVAESPQKWTQVASEIRGVTEETTTGVHRLYEMQRDGTLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKTAVVFGYGDVGKGCAESLRGQGARVIVTEIDPICALQAAMDGYQVTTLDEVVDKADIFITTTGNKDIIMASDMAKMKHQAIIGNIGHFDNEIDMAGLAKIPGVVKDEVKPQVHTWKFPDGKVLIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPDEYPTGVYVLPKHLDEKVARLHLDALGVKLTQLRPEQAAYIGVEVDGPFKPDHYRY
>NZ_CP022744.1|WP_170068302.1|4173225_4175262_-|PTS-sugar-transporter-subunit-IIA
MKLLAVTACPTGIAHTYMAAEKLAQAAESRGIEMKVETQGSIGAENVLTDNDVSTADGIIVAADKDVDLTRFVGKRVLTVGVAEGIRHPERLIERVRSAPVHAAGSDRPPVEGGKERSVGYKALMNGVSYMIPFVVVGGLLIAISLSLGGHTDPSGGLVIPKDSFWMDVNNIGVIGFTLMVPILSGYIAYAVGDRPALVPGMIGGWIANTGSLYDSKAGAGFIGAIVTGFLAGYLVLWIKKVKVPRFVQPIMPIIVIPIVATTALGLFFIYVIGKPISWVFEHLTSWLSGMTGTSAILLGAILGLMIAFDMGGPVNKTAFLFGTGLIATGNQTVMGMCAAAIPVMPLGQGLATLIRRRLYTEQERETGLAALFMGCFGISEGAIPFAAARPAQVIPANMLGGAVAGAIAGVAGVEDAVPHGGPIVAVLGAVSGVPMFFVAVVVGSVATALTTVALVDIGERRRRGGGAPVAGVGAGGPESKPEPEPAPVGVGGRGAPGADTAVARQAVVVSSPGAGVEPVEAGGSGEGVLSGYLTEETVKVRLDARDKEGAIREMAELLARAGEVTDVEELVATALRREAQGTTGLGEEIAIPHAKTDAVTAPVVGFARSAEGVEWGSLDGTKARLVFMIAVPEAAAGDEHLRILALLSRKLMDPGFRERLTAAPDAGAVLGVLREIR
>NZ_CP022744.1|WP_067433794.1|4171381_4172362_+|cation-diffusion-facilitator-family-transporter
MSASGGTKAIVAALAANLAIAVAKFVAFLFSGSSSMLAESVHSLADSGNQGLLLVGGKKAQREATPQHPFGYGRERYIYAFLVSIVLFSVGGMFAIYEGYEKIVHPHDIKHWYWPVGVLVFAIIAETFSFRTAIKESNTLRGKQSWKEFVRHAKAPELPVVLLEDLGALVGLILALGGVGMALATGDGVWDGIGTLCIGVLLILIAIVLAIETKSLLLGEAAGLDAVQKIETAIVDGDTVTGIIHMRTLHLGPEELLVAAKIAVQHDDTATEIASAINAAEARIREAVPIARVIYLEPDIFSESEAAKGPDREAAPGGPTSHPAEH
>NZ_CP022744.1|WP_067433763.1|4191973_4193122_+|S-methyl-5-thioribose-1-phosphate-isomerase
MADQYAQTGEDSRPTEIPAIRWEEPPEGPVLVLLDQTRLPAEEVELVCTDASALVEAIRSLAVRGAPLLGIAGAYGVALAAARGFDVDDAANSLAGARPTAVNLAVGVRRARAAFQAELGKGGDARQAAEAALAAARKLHREDAEASARMAERGLALLDELLPGGGHRILTHCNTGSLVSGGEGTAFAVALAAHRVGRLRRLWVDETRPLLQGARLTAYEAARSGMAYTLLTDNAAGSLFAAGEVDAVLIGADRIAADGSVANKVGSYPLAVLARYHHVPFIVVAPVTTIDLDTPDGASIEVEQRPGHEVTEVTAPQVPVAGAEAGGGIPVAPLGTQAYNPAFDVTPPELVTAIVTEEGAVSPVTAEALAELCARSRQVTIS
>NZ_CP022744.1|WP_187284748.1|4193126_4193816_+|two-component-system-response-regulator-MtrA
MMSFMKGRVLVVDDDTALAEMLGIVLRGEGFEPSFVADGDKALAAFRESKPDLVLLDLMLPGRDGIEVCRLIRAESGVPIVMLTAKSDTVDVVVGLESGADDYIVKPFKPKELVARIRARLRRSEEPAPEQLAIGDLVIDVAGHSVKRDGQSIALTPLEFDLLVALARKPWQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVEKDPERPEIVVTVRGVGYKAGPS
>NZ_CP022744.1|WP_067433760.1|4193817_4195962_+|HAMP-domain-containing-protein
MSGDSAASSPGRTGARAERPVGRKKAGSRWGRFLEGGLLQGGVQGSPVLRLFMRWVRRPLLPVMRLWRRNIQLKVVVTTLLMSLGVVLLLGFVVIGQVRNGLLDAKVKASQSQATGGFAVAKQKAEEAGTGAGDDGAPVDEHTEQNVIQWMSDLVESLSSGGQGAFDVVTLPAAGDASGGGRGPRASGDVDWSASVPEALRERVDSSTAAAQSYTRIVYDDTAGKEAQPGLVIGKQVNDPNDDPYQLYYLFPLTQEEKSLSLVKGTLATAGLFVVVLLGAIAWLVVRQVVTPVRMAAGIAERLSAGRLQERMKVTGEDDIARLGEAFNKMAQNLQLKIQQLEDLSRMQRRFVSDVSHELRTPLTTVRMAADVIHEAREDFDPVTARSAELLADQLDRFESLLADLLEISRFDAGAAALEAEPIDLREVVRRVLSGAAPLAERKGTHIRVVGDQQPVVAEADARRVERVLRNLVVNAVEHGEGKDVVVKLAAAGGAVAVAVRDYGVGLKPGEATRVFSRFWRADPARARTTGGTGLGLSIALEDARLHGGWLQAWGEPGGGSQFRLTLPRTADEPLRGSPIPLEPKDSRRNRGLDDAGLPRGNAEKAATVPAQPSRDPVTSRDPIAPRPTGMAATADPTALPGNGARVVPRPASGVRRQDDTSVGDAPRGGPEGSAGTGPEAPHGHPEEPHEQAQAQASYGQEDSHSQGEAFRGR
>NZ_CP022744.1|WP_067433756.1|4195951_4197781_+|GerMN-domain-containing-protein
MGADREGRARRGPGRVAAYAACGVVLLAGCASMPDSGDLRGVDSTPRQDTQVRVFAMPPQEDATSGEIVQGFLEALTSDDPKYETARKYLTNEAAKSWHPELSTTVLAEAPDMDPRRSGGREDTADDLYTLTGTKVATVDAQQSYEPADGSYDQSVHLVRDPKTKQWRIDGPPPGVVMGKSDFQRNYLSVDKYYFADYPVSGTSPTTVAVADPVYVRERVNPMTQMVRSLLNGPTTWLEPVAGSSFPTGVRLQDDGASLTPDDQNKLTVPLNDRAARVGVSVCHRMAAQVLFTLQDLTPAVDEVELRAGGKQLCSLKEDDAPAVATRGSVQQPEYLYFVDARKRLVRMAADSSGTQHDPVPGALGDGDKALQSVAVSRDEHKAAGVATDGKELYVASLAAAGSLGDAVLTSKGATANDRLTTPSWDAQGDLWVADRDPRDPRLVVLEDGGGDPFTVDIPGLEGRIKDVRVAADGVRIALVVEKGGKQSLLIGRIERSEKSERPAVAVRELRSAAPELEEVAAMSWAGDSRLVVVGRERGGVQQTRYVQVDGSTPEGPAPAALTGVKEIAASEDDQMPLVAYSEDGIVRLRTGTQWEKVDAEGTAPVYPG
>NZ_CP022744.1|WP_067433752.1|4198001_4199213_+|ComF-family-protein
MRGWWQDLTDLVLPAECGGCGRPRAVLCPQCRAVLSGAVPRRVRPVPEPLGLPVVHAAARYADEVRAALLAHKERGAMALAAPLGAALAGAVRAGLQEARGRAGSSDWTEGAGAWADGRERRTWGRDGAVWGGARGTRVWVDGGEPVDGDDGGAWADGGASAGGTAGVGSGDAHAHGRGHDHGHRHGRMDAGGRGGAHGGPGRWGDGTVLLVPVPSARRAVRARGHDPARRIALAAAGELRRSGTPARVLAVLRQGRRVADQAGLNSRQRLENLAGALEVAPGAGRLLDEGPVVLVDDLMTTGASLAEAARAVRAGRDHGTVGSQGAFARAVSVGAGEREEVARTVYAAVSRESREERMTGVMEEETAAVPRRPGMAGVGTAHDVICAAVVAASPDSFEINRN
>NZ_CP022744.1|WP_067433750.1|4199524_4200217_+|ribosome-associated-translation-inhibitor-RaiA
MDIVVKGRKTEVPERFRKHVAEKLKLEKIQKLDGKVISLDVEVSKEPNPRQADRCDRVEITLRSRGPVIRAEAAASDPYAALDLAAEKLDARLRKQHDKRHTRRGARRLTAAEVPDHVPGAATLNGNGHTVREEEPDGVPTKKIGSLEIKGEGPLVVREKTHVASPMTLDQALYEMELVGHDFYLFIDSETKEPSVVYRRHAYDYGVIHLSTDPMVTQAQPPAAGGTLGG
>NZ_CP022744.1|WP_067433747.1|4200421_4201168_+|response-regulator-transcription-factor
MADSFGPMQDEDAGDGAVGMGPDEGSPRKEPIRVLVVDDHALFRRGLEIVLAAEEDIQVVGEAGDGAEAVDKAADLLPDIVLMDVRMPKRGGIEACTSIKEVAPSAKIIMLTISDEEADLYDAIKAGATGYLLKEISTDEVATAIRAVADGQSQISPSMASKLLTEFKSMIQRTDERRLVPAPRLTDRELEVLKLVATGMNNRDIAKELFISENTVKNHVRNILEKLQLHSRMEAVVYAMREKILEIR
>NZ_CP022744.1|WP_067433744.1|4201208_4202381_-|winged-helix-turn-helix-domain-containing-protein
MTTPPPTIQLSADEARRIVLRAQGFLGAPDRKAGVRGILRHLGAVQLDTISVLARSHELIPYARLGAVDRRTVEKAYWTDTHAFEYWSHAACILPIEEWPHFAFRRRSYRSRPHWNHQLPDGVYDQVIKQLRAEGPLTATELGGAKRTSEWWDWSGTKVAVERALMYGEVVCVERRGWKRVYDLAERAVPDSLLHDDLDDTECLRRLVRLAGQSLGVGTRADIADYHRLKGEQVDAVIADSGLVPVTVEGWGKPAWADPAALETPPRGRHRTTLLSPFDSLIWERARTERVFGFTHRLEAYVPKPKRVYGYFAMPVLAGGHLVGRVDPAREGRTLVAKQVTLDGPKAVPAVAQALVEAASWVNCTDVRVEKVAAPELREALAREVTRATP
>NZ_CP022744.1|WP_067433741.1|4202490_4203072_-|GNAT-family-N-acetyltransferase
MDPVTLTTGRLLLRTVGPQDTDVVYAAAQDPEIQRWTTIPVPYLPEHARSFTDQLVPEGWANGSMLTWGLFLPEGEELVGMLSLTMRTLGAAEVGFWSAGRHRGRGYVTEAVLAVARWAFTDLSLDRVEWRAEVGNTASRAVAERAGFVIEGVMRSAIIHRGARRDCWVGALLPSDLALPSTAPYLPAPVQPA
>NZ_CP022744.1|WP_067433738.1|4203342_4206180_+|preprotein-translocase-subunit-SecA
MSVLSKIMRAGEGKILRKLHRIADQVNSIEEDFVDLSDAELRALTEEYKQRYADGETLDDLLPEAFATVREAAKRVLGQRHYDVQIMGGAALHLGYVAEMKTGEGKTLVGTLPAYLNALSGKGVHLITVNDYLAERDSEMMGRVHKFLGLEVGCILANMTPSQRREQYACDITYGTNNEFGFDYLRDNMAWSHDELVQRGHNFAIVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLKRGEAGNPLKGVEETGDYDVDEKKRTVAIHESGVSKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVMDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYKRHDHNDKEQPGLCGMTGTAMTEAAEFHQIYKLGVVPIPTNRPMIRKDQSDLIYRTEVAKFEAVVDDIAEKHEKGQPILVGTTSVEKSEYLSQQLSKRGIQHEVLNAKQHDREATIVAQAGRKGAVTVATNMAGRGTDIKLGGNPEDLAEAELRQRGLDPEEHIEEWAAALPAALKNAEQAVKTEFEEVKDLGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMSMANVPDDVPIENKMVTRAIASAQSQVEQQNFETRKNVLKYDEVLNRQREVIYGERRRVLKGEDLHEQVQHFMDDTIDAYVGAETAEGFPEDWDLDRLWGAFKQLYPVKVTVEELEEAAGDRAGLTAEFISESIKDDIHDQYAEREAQLGSEIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFTAMMEGIKEESVGYLFNLEVQVEQQVEEVPVEDAKPSLDKQDAVPAQAGARPEIRAKGLDVPQRRELHFSAPTVDGEGGVVEGDFAEDEPVRSESDGLTRAERRKQSRGGRRRKK

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Crispr_ID: NZ_CP022744_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022744_2

5706320-5706407

Orphan

Consensus_repeat	Method
CGAGCCCGTCGGGCAGGGCGAACTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022744_2

>merge|NZ_CP022744|2|5706320-5706407|CRISPRCasFinder
CGAGCCCGTCGGGCAGGGCGAACTCCGAGGTGGTCTCCGGTTCGGCCCCCGCTCTGAGCACGGCGAGCCCGTCGGGAAGGGCGAACTC

>NZ_CP022744|2|2|5706320-5706407|CRISPRCasFinder
CGAGCCCGTCGGGCAGGGCGAACTC	CGAGGTGGTCTCCGGTTCGGCCCCCGCTCTGAGCACGG
CGAGCCCGTCGGGAAGGGCGAACTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022744.1\|WP_067437467.1\|5716118_5716478_-\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_CP022744.1\|WP_079164722.1\|5707162_5708824_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|200042
NZ_CP022744.1\|WP_067437436.1\|5696542_5698003_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143469
NZ_CP022744.1\|WP_030043337.1\|5711412_5711973_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP022744.1\|WP_067437462.1\|5714339_5714945_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NZ_CP022744.1\|WP_067437438.1\|5698105_5698651_+\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP022744.1\|WP_067437453.1\|5706591_5707083_-\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP022744.1\|WP_067437442.1\|5699429_5700380_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP022744.1\|WP_067437466.1\|5715513_5716122_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP022744.1\|WP_067437449.1\|5703933_5704791_+\|VTT-domain-containing-protein	unknown	unknown	gnl\|CDD\|182775
NZ_CP022744.1\|WP_067437444.1\|5700376_5701138_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP022744.1\|WP_067437457.1\|5708932_5710057_+\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|274833
NZ_CP022744.1\|WP_067437440.1\|5698669_5699308_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP022744.1\|WP_067437461.1\|5712180_5714220_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NZ_CP022744.1\|WP_067437445.1\|5701192_5702605_-\|glutamate-decarboxylase	unknown	unknown	gnl\|CDD\|130848
NZ_CP022744.1\|WP_079164721.1\|5694754_5695261_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP022744.1\|WP_067437434.1\|5695605_5696430_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP022744.1\|WP_067437459.1\|5710269_5711340_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|274129
NZ_CP022744.1\|WP_067445698.1\|5702727_5703489_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP022744.1\|WP_067437464.1\|5714957_5715443_-\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650

Protein	Function_ID	Function_description	E-value
NZ_CP022744.1\|WP_067437467.1\|5716118_5716478_-\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	2.35263e-45
NZ_CP022744.1\|WP_079164722.1\|5707162_5708824_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|200042	TIGR00666, D-alanyl-D-alanine_carboxypeptidase_DacB, D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family. In E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	5.95964e-43
NZ_CP022744.1\|WP_067437436.1\|5696542_5698003_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0
NZ_CP022744.1\|WP_030043337.1\|5711412_5711973_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	6.27825e-91
NZ_CP022744.1\|WP_067437462.1\|5714339_5714945_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	1.44635e-117
NZ_CP022744.1\|WP_067437438.1\|5698105_5698651_+\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	4.57535e-46
NZ_CP022744.1\|WP_067437453.1\|5706591_5707083_-\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	2.10724e-83
NZ_CP022744.1\|WP_067437442.1\|5699429_5700380_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.75949e-116
NZ_CP022744.1\|WP_067437466.1\|5715513_5716122_-\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	3.18643e-65
NZ_CP022744.1\|WP_067437449.1\|5703933_5704791_+\|VTT-domain-containing-protein	gnl\|CDD\|182775	PRK10847, PRK10847, DedA family protein.	7.65412e-65
NZ_CP022744.1\|WP_067437444.1\|5700376_5701138_+\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	1.84173e-16
NZ_CP022744.1\|WP_067437457.1\|5708932_5710057_+\|zinc-dependent-metalloprotease	gnl\|CDD\|274833	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated. A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.	5.23796e-170
NZ_CP022744.1\|WP_067437440.1\|5698669_5699308_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.16093e-09
NZ_CP022744.1\|WP_067437461.1\|5712180_5714220_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP022744.1\|WP_067437445.1\|5701192_5702605_-\|glutamate-decarboxylase	gnl\|CDD\|130848	TIGR01788, Glutamate_decarboxylase_alpha_GAD-alpha., glutamate decarboxylase. This model represents the pyridoxal phosphate-dependent glutamate (alpha) decarboxylase found in bacteria (low and hi-GC gram positive, proteobacteria and cyanobacteria), plants, fungi and at least one archaon (Methanosarcina). The product of the enzyme is gamma-aminobutyrate (GABA).	0
NZ_CP022744.1\|WP_079164721.1\|5694754_5695261_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.59098e-23
NZ_CP022744.1\|WP_067437434.1\|5695605_5696430_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	6.39249e-09
NZ_CP022744.1\|WP_067437459.1\|5710269_5711340_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	9.78021e-63
NZ_CP022744.1\|WP_067445698.1\|5702727_5703489_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	2.60904e-51
NZ_CP022744.1\|WP_067437464.1\|5714957_5715443_-\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	1.39958e-30

>NZ_CP022744.1|WP_067437449.1|5703933_5704791_+|VTT-domain-containing-protein
MTTLALGPEWLSPDYLIETFSLPGILLIVFAESGLFAFLPGDSLLFTAGLFVAEGNFISQPLWLVCTLIVLAAVIGDQVGYMIGKFFGPKLFSRPNSKLFKQENLEKAHEFMEKYGPKAIVLARFVPIVRTFAPIVAGAGRMKYRTFLTYNIIGGVAWGCGVTLAGYWLGQIEFIKTNVEAILVLIVIVSVVPIIVEFLRERGKKKRAAAEAPAQARQHPQMMDDATTQLRRIPSPDEPQQPYGNQGQHTGYDQPYYGQPPQQQQPYAQQYPQNHNQQYPDNRGY
>NZ_CP022744.1|WP_067445698.1|5702727_5703489_+|MerR-family-transcriptional-regulator
MSYSVGQVAGFAGVTVRTLHHYDDIGLLVPSERSHAGHRRYSDADLDRLQQILFYRELGFPLDEVAALLDDPAADPRAHLRRQHELLTARIEKLQKMAAAVEHAMEARKMGINLTPEERFEVFGDKDPEQYAEEAERRWGGTEAYAESQRRAARYTKEDWKRLQAEVNDWAERYTAVLAEGEPPTGERAMDLAEEHRRHIGTWYYECPYEMHRSLAEMYVSDERFKAFYDSMRPGLAEHLRDAILANADRRTA
>NZ_CP022744.1|WP_067437445.1|5701192_5702605_-|glutamate-decarboxylase
MPLHQGPEQPDERPLSVNPFYGEADPVGGMAEAPPKHRLPAAPLPPSTAYQLVHDELMLDGNSRLNLATFVTTWMEPQAGVLMDECRDKNMIDKDEYPRTAELERRCVAMLADLWHAPDPSAAVGCSTTGSSEACMLAGMALKRRWARRNADRYPSRDVRPNLVMGVNVQVCWEKFCTFWEVEARQVPMEGDRFHLDAQAAAELCDENTIGVVGILGSTFDGSYEPVAELCAALDALQERTGLDIPVHVDGASGAMVAPFLDEDLVWDFRLPRVASINTSGHKYGLVYPGVGWALWRDQEALPEELVFRVNYLGGDMPTFALNFSRPGAQVVAQYYTFLRLGREGYRAVQQSTRDVARGLAARVEALGDFRLLTRGDELPVFAFTTAPGVEAYDVFDVSRRMRERGWLVPAYTFPPNREDLSVLRVVCRNGFSADLAELFVEDLGRLVPELRRQPHPLTRDKEAATGFHH
>NZ_CP022744.1|WP_067437444.1|5700376_5701138_+|ABC-transporter-permease
MSTYALTDSWTMTRRELAHWVRQPVQVVVQLAFPVMLLLMFGYLVGGGRGVEGSYVDYLVPGMLALTMAFGLEGTMLAVTQDLNKGVIDRFRSMPMTNGAVLVGRSVADMLESAVSLLVMIGVAFALGWRAHGGVGGFLGALGLLLLFRFAMLWIGIHLAMVAGKPEMVQAVQILVWPVGFLSNAFATPHSMPGWLGTVIEWNPMSHTATAVRDLFGGQGGEPGHVWPAALWPLALLAVFLPLAVRRFGALSK
>NZ_CP022744.1|WP_067437442.1|5699429_5700380_+|ATP-binding-cassette-domain-containing-protein
MTDAIVAEGLRKRYGDKAALDGLGLRVARGTVHGVLGPNGAGKTTLVRILSTLLRPDAGRVEVAGHDVLAEAQAVRFRIGLLGQHAALDEELSGRQNLDMFGRLYHLGARQARVRADELLERFTLADTGRKAVKQYSGGMRRRLDLAASLITEPEVLFLDEPTTGLDPRGRTEVWAAVRSLVGGGTTVLLTTQYLQEADQLADRVSIVDRGRIVADGTPDQLKSVIGGDRIDVVLRDAGQLGAAVALLPLPASEVSVDTDRRLLSAPVTDRMAALSGVVRALEEAGIEAEDVALRRPTLDEVFLHLTGDDRVKEAV
>NZ_CP022744.1|WP_067437440.1|5698669_5699308_+|PadR-family-transcriptional-regulator
MSAIRLLVLGAVRMHGRAHGYQVRGDLEYWGAHEWSNAKPGSIYHALKQMAKQGLLHAHEIAPSTAGGPPRTEYEITERGIEEYHRLLREALVTYDQRGDVKTAAVGFLVDLPRAEAVALLKERTRRIVEWRSGVLEHYVPEDGPGQLGHIGEIMNMWVHTADSEAEWTHGLIERIEGGAYTFADEGDPFVDVRTPDPNPYATGARHPEDSL
>NZ_CP022744.1|WP_067437438.1|5698105_5698651_+|DinB-family-protein
MVTHVRAEAYGDERGALLSFLAEQRGGIRRSVLGLTHEQASSRPSASELSLAGLLKHVAEVEQGWVARAKGEPPAVKRDESNWHECFTLVDGESVEQQLAYWETVAAETEAFVRSAPSLDDTFPLPDEPWFPPDEAVSVRWLVLHLIRETARHAGHADILRESLDGRTAFELVALAAAPAG
>NZ_CP022744.1|WP_067437436.1|5696542_5698003_+|aldehyde-dehydrogenase-family-protein
MSSYFTDLAQQYIDGEWRQGTGSWDIIDFNPYDNEKLASITIATVDEVDEAYRAAARAQKAWAATNPYARRGVFEKALRLVEEREQEIADVIIAELGGTRLKAAFELHLVKEFLRESVHLALRPEGRILPSPTDGKENRLYRVPVGVVGVISPFNFPFLLSIKSVAPALALGNAVVLKPHQNTPIVGGSLVAKIFEDAGLPAGLLNVVITDIAEIGDAFIEHPVPKVISFTGSDRVGRHVATVCAANFKRSVLELGGNSALVVLDDADLDYAVDAAVFSRYVHQGQVCMAANRILVDRSVAEEFTEKFVAKVRTLKTGDPRDPETVIGPVINSSQADALSSVVEQAIAEGATALVHGTTTDNLVEPSVLTGVPADSALLRQEVFGPVAFLIPFDGEEEAVRLVNDTPYGLSGAVHTGDIERGVAFAKQIDTGMFHVNDGTVHDEPLVPFGGEKHSGIGRLNGESTAESFTTLKWISVQHGRSRFPF
>NZ_CP022744.1|WP_067437434.1|5695605_5696430_+|helix-turn-helix-domain-containing-protein
MLLGSQLRRLREARGITREAAGYSIRASESKISRMELGRVSFKTRDVEDLLTLYGITDEQERTSLLSLAREANVAGWWHSYSDVLPSWFPTYVGLEGAAALIRAYEVQFVHGLLQTEAYARAVVRRGMKGASEADVERRVGVRLERQKYLVDENAPDVHIVLDEAALRRPYGDREVMRGQLQHLIEISERPNVRLQIMPFGFGGHSGESGAFTILSFPDSDLSDVVYLEQLTSALYLDKREDVTQYEKALKELQQDSPGPDESRDLLRGLLQLS
>NZ_CP022744.1|WP_079164721.1|5694754_5695261_-|ATP-binding-protein
MATNGSTMLKPLRQGLPPLDPAAVSSAASCALPARYEAVREARQFTRRSLDQWELGDRFDDVCLVVSELVTNALRHALPANTPRPAEQNAPVRLHLMRWTERLVCAVRDPSDESPVARDTDDFSAESGRGLFLVDSFADGWGWHPLAGSLGGKVVWALFRLQQPPSAE
>NZ_CP022744.1|WP_067437453.1|5706591_5707083_-|inorganic-diphosphatase
MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTAYPTDYGFVENTLGEDGDPLDALVILDEPTFPGCLIKCRAIGMFRMTDEAGGDDKLLCVPATDPRVEHLRDIHHVSEFDRLEIQHFFEVYKDLEPGKSVEGADWVGRTEAEVEIERSYKRFKDQGGH
>NZ_CP022744.1|WP_079164722.1|5707162_5708824_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MVVPELRPWRAAKPRVTRVANAVRPRLTRASDAVRPRIARAADVVRPRLARATTAAKPQVTRFAQAVKPQLDRIPRPKTAKTWHYTAGAATAGLALAASVVTVAGPWDSTGQRTAERDRAAALDHTGGADHDGSSGTADGAPEPAPSAASVLVGLGGAANTVRSAPTGPGLASVLGPLLKDPALGTSRSAVVVDVATGKRLYGEGAERALTPASTTKIATAVAALTALGADHRLTTRADLEADTKELVLVGGGDPTVTAHQDAQGWASLRTLADRTAAALKKRDIRQVTLSYDTTLYPGTELHPIGENENLAPVTALMVDEGRMDDSTSGTADRFEDPATQAARQFAGLLAAHGIKTTAPGPSKATGRAENLATVSSPPLSAVVERMLTNSDNDIAEALARQTAVATGERADFDGAGRAITAQLRKLGLPVKGVAFHDGSGLDRDDRLTAGLLTALLAKAGDPSRPDLRPVLTGLPVAGFTGTLTTRYTDGAAGIVRAKTGTLNGVNTLAGTVVDHNGRLLAFAFLASGTTNKDAAQSALDRTATALAACGCR
>NZ_CP022744.1|WP_067437457.1|5708932_5710057_+|zinc-dependent-metalloprotease
MTSIGGAEMVDWNLAVATATRLVRPGPDVSRDEARAVVAELRRHAKASEEHVRGFTRMGTEGLHDTPILVVDRPGWVRANVAGFREILKPLLDKMQERRGNTPGGAVMSAVGGKVTGVELGMLLSFLASRVLGQYETFAPSTRELPAGENGGGRLLLVAPNIVHVERELDVQPHDFRLWVCLHEETHRTQFTAVPWLRDHLEGEIQSFLGETEVDPMTVLERVREAAQSLAGGRPEGEEDDGGRSLVEIVQTPAQREILGRLTAVMSLLEGHADFVMDGVGPSVVPTVQEIREKFQQRRAKGASRLDLALRKLLGLDAKLRQYRDGEKFVRAVVDQVGMDGFNRVWTSPNTLPTKAEIAKPADWVARVHRKAES
>NZ_CP022744.1|WP_067437459.1|5710269_5711340_+|tRNA-lysidine(34)-synthetase-TilS
MGPHPAVAAIRLAVRRVLHDILNEAGRTAVYSRTTGAPPASDATPHERPPSPLVLVACSGGADSMALASALAFEAPKLGIRAGGITVDHGLQPGSDLRADEVVLRLRELGLDPVESTAVTVGREGGPEAAARDARYAALDAAAERHDAAAVLLGHTRDDQAETVLLGLARGSGVRSLSGMAAVSGGPGAARRYRRPFLQLDRQTARKACMAQSLPVWDDPHNADPAYTRSRLRHEGLPALEKALGKGVVEALARTAQLSRDDADALDAWAGQAEASVRDAAGLLECAKLYALPPAVRRRILRRAAIEAGAPAGSLFARHIEEVDRLITGWRGQGAINLPGKVVAQRQGGRLVIRQG
>NZ_CP022744.1|WP_030043337.1|5711412_5711973_+|hypoxanthine-phosphoribosyltransferase
MRVDAKDMGTDLKEVLITKEEIDAKLVELAAKIDAEYAGKDLLIVGVLKGAVMVMADLARALSTPVTMDWMAVSSYGAGTQSSGVVRILKDLDTDIKGKHVLIVEDIIDSGLTLSWLLSNLGSREPESLKVCTLLRKPDAAKVAIDVEWVGFDIPNEFVVGYGLDYAEKYRNLPFVGTLAPHVYGG
>NZ_CP022744.1|WP_067437461.1|5712180_5714220_+|ATP-dependent-zinc-metalloprotease-FtsH
MDVKRYFRGPVMWIVLAVLAVVVLMQVVGSSGGYKTVDTGQVIQAINDNKVESAKLTTGDEQTIKVQLKDGEKVEGSSKIQASYIGDQGATLAGTLQNKYQDKQIPDGYTVSPTKQNAFVGILLSLLPFVLIVVVFLFLMNQMQGGGSRVMNFGKSKAKLITKDTPKTTFADVAGSDEAVEELHEIKEFLQEPAKFQAVGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKANAPAIVFVDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFDVKGGVILIAATNRPDILDPALLRPGRFDRQIAVDRPDMQGRLEILKVHQKGKPVAPDVDLSAVARRTPGFTGADLSNVLNEAALLTARSNQKLIDNHMLDEAIDRVVAGPQKRTRIMSDKEKKITAYHEGGHALVAAASPNSDPVHKITILSRGRALGYTMVLPDEDKYSTTRNEMLDQLAYMLGGRAAEELVFHDPTTGAANDIEKATATARAMVTQYGMTERLGAIKFGGDNTEPFLGREMAHQRDYSEEVAALVDEEVKKLIETAHNEAWEILVENRDVLDNLVLQLLEKETLNKEQIAEIFAPIVKRPPRPAWTGSSRRTPSTRPPVLSPRELALTNGANGATPAITTAKSTAAEPAPVAEPAPEDRPES
>NZ_CP022744.1|WP_067437462.1|5714339_5714945_+|GTP-cyclohydrolase-I-FolE
MTDPVTLDGEGSIGEFDEKRAENAVRELLIAVGEDPDREGLRETPARVARAYREIFAGLWQQPEDVLTTTFDLGHDEMVLVKDIEVYSTCEHHLVPFRGVAHVGYIPAVSGKITGLSKLARLVDVFARRPQVQERLTTQIADSLMQILEPRGVIVVVECEHMCMSMRGIRKPGAKTITSAVRGQLRDAATRNEAMSLIMAR
>NZ_CP022744.1|WP_067437464.1|5714957_5715443_-|DUF3180-domain-containing-protein
MRELRIRVLAGVFAVAGILSWAGARLWNSVGTLPSVPLAAPVVLALIAAVLLSTALSIRARLKAQRDRNPGAKGVDPLMAARAVVFGQASALVAALVSGMYGGTGVFLLESLDIPARRDQAIYAGFSVLAGIAVIVAAIFLERVCRLPEDDDRNTGATSTA
>NZ_CP022744.1|WP_067437466.1|5715513_5716122_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTAFAKGPTDPTVQPVPASVVEKVDAADTTLHNPKRAVISLGANLGNRLETLQGAIDALEDTPGVRIKAVSPVYETEPWGVEPGSQPSYFNAVVVLKTTLPPSSLLERAHAIEEAFHRVRDERWGARTLDVDIVAYADVLDDDPHLTLPHPRAHERAFVLVPWHDLEPAAQLPGRGAVADLLDTVARDGVEPRKDLELRLPE
>NZ_CP022744.1|WP_067437467.1|5716118_5716478_-|dihydroneopterin-aldolase
MDRVALRGLKARGHHGVFPKEREEGQTFLVDLVLGLDTRPAAADDDLAKTVHYGIVAEEVVAVVEGEPVNLIETLAERIAQACLKHEGVQEVEVCVHKPDAPITVPFDDVTVTITRSRV

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Crispr_ID: NZ_CP022744_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022744_3

7625791-7625906

Orphan

Consensus_repeat	Method
TCATCGACCGGCCTCCTGCGTGGTGTTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022744_3

>merge|NZ_CP022744|3|7625791-7625906|CRISPRCasFinder
TCATCGACCGGCCTCCTGCGTGGTGTTGAGACTGTGCTTTCCCGGGGGATAACCCCCGGGCCCCCAGCCGAGTGTGTACTCGACGTTCATCGACCGGCCTCCTGCGTGGTGTTGAG

>NZ_CP022744|3|3|7625791-7625906|CRISPRCasFinder
TCATCGACCGGCCTCCTGCGTGGTGTTGAG	ACTGTGCTTTCCCGGGGGATAACCCCCGGGCCCCCAGCCGAGTGTGTACTCGACGT
TCATCGACCGGCCTCCTGCGTGGTGTTGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022744.1\|WP_079164492.1\|7630386_7631763_+\|CynX/NimT-family-MFS-transporter	unknown	unknown	gnl\|CDD\|129974
NZ_CP022744.1\|WP_067430081.1\|7622725_7623004_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|182475
NZ_CP022744.1\|WP_067430084.1\|7622059_7622479_-\|DUF3099-domain-containing-protein	unknown	unknown	gnl\|CDD\|378630
NZ_CP022744.1\|WP_067430093.1\|7618515_7618872_+\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_CP022744.1\|WP_067430055.1\|7632104_7632311_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067430046.1\|7636643_7639166_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP022744.1\|WP_067430066.1\|7628359_7629127_+\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236124
NZ_CP022744.1\|WP_067430049.1\|7634376_7636404_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP022744.1\|WP_067430052.1\|7632969_7634196_-\|phosphoserine-phosphatase-SerB	unknown	unknown	gnl\|CDD\|319803
NZ_CP022744.1\|WP_067430064.1\|7629292_7629646_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067430078.1\|7623066_7624335_-\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NZ_CP022744.1\|WP_079164493.1\|7620573_7621626_+\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NZ_CP022744.1\|WP_067430087.1\|7621608_7621833_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_182449155.1\|7615042_7616611_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173799
NZ_CP022744.1\|WP_067430099.1\|7613589_7614969_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP022744.1\|WP_067430062.1\|7629620_7630316_-\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP022744.1\|WP_067430069.1\|7627649_7628354_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|273824
NZ_CP022744.1\|WP_067430096.1\|7616708_7618238_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173810
NZ_CP022744.1\|WP_067430090.1\|7618868_7620497_+\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NZ_CP022744.1\|WP_067430053.1\|7632376_7632895_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973

Protein	Function_ID	Function_description	E-value
NZ_CP022744.1\|WP_079164492.1\|7630386_7631763_+\|CynX/NimT-family-MFS-transporter	gnl\|CDD\|129974	TIGR00896, Inner_membrane_transport_protein_YeaN, cyanate transporter. This family of proteins is involved in active transport of cyanate. The cyanate transporter in E.Coli is used to transport cyanate into the cell so it can be metabolized into ammonia and bicarbonate. This process is used to overcome the toxicity of environmental cyanate. [Transport and binding proteins, Other].	2.74616e-123
NZ_CP022744.1\|WP_067430081.1\|7622725_7623004_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|182475	PRK10457, PRK10457, hypothetical protein; Provisional.	1.33568e-06
NZ_CP022744.1\|WP_067430084.1\|7622059_7622479_-\|DUF3099-domain-containing-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	8.01716e-20
NZ_CP022744.1\|WP_067430093.1\|7618515_7618872_+\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	1.3655e-33
NZ_CP022744.1\|WP_067430066.1\|7628359_7629127_+\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	3.23068e-172
NZ_CP022744.1\|WP_067430049.1\|7634376_7636404_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.74644e-07
NZ_CP022744.1\|WP_067430046.1\|7636643_7639166_+\|FHA-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.73984e-74
NZ_CP022744.1\|WP_067430078.1\|7623066_7624335_-\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_CP022744.1\|WP_079164493.1\|7620573_7621626_+\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	4.75303e-180
NZ_CP022744.1\|WP_182449155.1\|7615042_7616611_-\|S8-family-serine-peptidase	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.2079e-51
NZ_CP022744.1\|WP_067430052.1\|7632969_7634196_-\|phosphoserine-phosphatase-SerB	gnl\|CDD\|319803	cd07500, HAD_PSP, phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p. This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.18441e-93
NZ_CP022744.1\|WP_067430096.1\|7616708_7618238_-\|S8-family-serine-peptidase	gnl\|CDD\|173810	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins. Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	4.80957e-54
NZ_CP022744.1\|WP_067430099.1\|7613589_7614969_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	6.69895e-43
NZ_CP022744.1\|WP_067430062.1\|7629620_7630316_-\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.44515e-51
NZ_CP022744.1\|WP_067430069.1\|7627649_7628354_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|273824	TIGR01830, 3-oxoacyl-_reductase_FabG, 3-oxoacyl-(acyl-carrier-protein) reductase. This model represents 3-oxoacyl-[ACP] reductase, also called 3-ketoacyl-acyl carrier protein reductase, an enzyme of fatty acid biosynthesis. [Fatty acid and phospholipid metabolism, Biosynthesis].	2.48026e-122
NZ_CP022744.1\|WP_067430090.1\|7618868_7620497_+\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP022744.1\|WP_067430053.1\|7632376_7632895_+\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	4.884e-42

>NZ_CP022744.1|WP_067430078.1|7623066_7624335_-|tyrosine--tRNA-ligase
MTDIVDELKWRGLWALSTDEDALRKALADGPVTFYCGFDPTAASLHVGHLVQVLTMRRLQQAGLRPLALVGGATGQIGDPRPTAERTLNDPETVANWVGRLRAQIEPFLSFEGENAATMVNNLDWTAGMSAIEFLRDIGKHFRVNKMLTKDSVARRLESQEGISYTEFSYQLLQGMDFLELYRRYGCTLQQGGSDQWGNLTAGLDLIHRLEPEASAHCLATPLMVKADGTKFGKTEGGAVWLDPEMTTPYAFYQFWLNVDDRDISTYMRILSFRSREELEELEQQTQERPQARAAQRALAEELTTLVHGAGQTAAVIAASRALFGQGDLAELDEKTLTAALSEVPHVRVPQLGPVVDLFAEVGLVASKSAARRTVKEGGAYVNNAKVTAEDAVASQEELLHGRWLVLRRGKKNLAAVEVTGA
>NZ_CP022744.1|WP_067430081.1|7622725_7623004_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGWLWAIIVGLVLGLIAKAIIPGKQHSPLWLTTIFGMLGAIVGNAIARWAGVDSTSGIDWSRHAFQLVAAVVIVAVGDMLYMATLGKRKQRT
>NZ_CP022744.1|WP_067430084.1|7622059_7622479_-|DUF3099-domain-containing-protein
MRKQHDGGNAQVFRITGARTGLQEDVRGRQRRYVISMTVRTIAVILAATLWDVERHVAIVALVLGMVLPYVAVVVANAGRENAPSLPSTFVTAPTPPMILPPRAEEGDGTPREGFAEPGPEDVPADPAPGARSEPHERA
>NZ_CP022744.1|WP_067430087.1|7621608_7621833_-|hypothetical-protein
MSDTPICSAKGCRADAVWVLAWNNPKIHTPERRKTWLACEEHREHLSQFLGVRGFLKDVVLLKEWEEGSSATDG
>NZ_CP022744.1|WP_079164493.1|7620573_7621626_+|GTP-3',8-cyclase-MoaA
MSDVSRRLTGEGNTVTREGAHVLIDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIDIAVTTLGIEEVRFTGGEPLLRPGLVGIVERVAALDPRPQMSLTTNGIGLKRTASALKAAGLDRVNVSLDTLRPDVFKTLTRRDRHQDVIAGLEAARDAGLTPVKVNSVLMPGLNDDEAPDLLAWAVEHDYELRFIEQMPLDAQHGWKRDGMITAGDILTSLRTRFELTEEGSDKRGSAPAERWIVDGGPHVVGVIASVTRPFCAACDRTRLTADGQIRTCLFAREETDLRAALRSGAPDEEIARIWRLAMWGKKAGAGLDDPTFVQPDRPMSAIGG
>NZ_CP022744.1|WP_067430090.1|7618868_7620497_+|cation-acetate-symporter
MSPAMSHVQLAANEASEHRPLIITLFALFVVATLFITVWAGRQTKDAADFYAGGRSFSAFQNGLAVSGDYMSAASFLGIAGAIALFGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRYTMGDVLAYRMRQRPVRTAAGTSTIVVSIFYLLAQMAGAGVLVSLLLGITTDAGKILIVALVGVLMIVYVSIGGMKGTTWVQMVKAVLLIGGTILITFLVLLKFNFNISDLLGKAAENSGKGAAFLEPGLQYGATGTSKLDFISLGVALVLGTAGLPHILIRFYTVPNAKAARKSVNWAIGIIGGFYLMTIALGFGAAALISQDEIIASNPSGNTAAPLLALHLGGVDSAWGAILLATISAVAFATILAVVAGLTLASSSSFAHDIYANVIRKGQATEKEEVRAARLATIGIGAVSILLGALARDLNVAGLVALAFAVAASANLPTILYSLFWKRFTTQGALWSIYGGLIVAVGLVLFSPVVSGDPKAMFPDVDFAWFPLKNPGIISIPFGFLMGWLGTVLSKEEPDVKKFAELEVRSLTGTGAH
>NZ_CP022744.1|WP_067430093.1|7618515_7618872_+|DUF485-domain-containing-protein
MATDAPPPSKEQHKLPSPEEFTEVHESAEFRELRRSYHSFAFPLTVGFIAWYLLYVLLSNYAGDFMGTKVVGNINVAFVLGIAQFVTTFLIAWWYSRHAAAKLDPKAEAIKSRMEGGA
>NZ_CP022744.1|WP_067430096.1|7616708_7618238_-|S8-family-serine-peptidase
MPHLRSRSRLALAVPVVLSLTASLGFLPAAAAAAPSTPSAAQTADAPALAYVVNTKADRRVIASVKRAVAAAGGTVVTTYDRIGVIVVHSSNPDFAKAMRAVRGVQSAGATRTTPLTAAGTTDEGAAQFLSKAQAAKAANASAAVPESEPLEADQWDLRAIGADKAAKINPGSRKVTVAVIDTGVDDTHPDLAPNFSASQSANCVGGVADTAAGAWRPYTPEDYHGTHVAGEIAAARNGIGVAGVAPGVKVAGIKVSDPDNGLFYPESVVCAFVFAADHGVEITNNSYYVDPWLYNCMDDPDQKAIVDAVNRAQLYAQRKGTLNLASAGNSNHDLDSDAIVDTTSPDDSTPVTRTIDPHECFDVPTQLPGVVTVSATGVQNLKSYYSTYGKGVVDVAAPGGDRRYQLPDTPSKDGRILSTMPNGQYAFLQGTSMASPHAAGVAALLKSKHPFATPAQLQALLKAQADNPGCPASYDQDGDGTQDAVCEGGKRVNGFYGYGIVNALRAVK
>NZ_CP022744.1|WP_182449155.1|7615042_7616611_-|S8-family-serine-peptidase
MTVVHPRFRRAITIPLGMTMATAMAFLPTATASASVLPDTVHGVTGTVNDVLASVGKADAGALSYVVNVRPGKAPSATVKKAIADAGGTIVTSYDQIGVIVVHSSNPDFAKTVRKVKGVDSAGNTRNAPLPAQSTEDLGAPKALTATELAAAEAKADAGQDPLENLQWDLPAIKADKAHEKTLGSGKVTVAVIDTGVDDTHPDIAPNFDRAASVNCVTGKPDTADGAWRPSASESPHGTHVAGEIAAAKNGVGMTGVAPGVKVSGIKVSTTAGYFYTEAVVCGFMWAATHGVDVTNNSYYTDPWYFNCTDDPDQKALVDAVSRASRYAEKKGVVNVAAAGNENYDLAADEITDPVSPNDGTPSDRVVDPSKCLDIPTQLPGVVTVASTGAKGIKSSFSNHGLGVIDVAAPGGDSTAYQTPAPPATSGLILGTLPGGKWGYMAGTSMASPHAAAVAALIKSTHPYAPPALVKALLYAEADATPCTDPYDINGDGKVDAVCEGSKNRNGFYGWGTVDALDAVTK
>NZ_CP022744.1|WP_067430099.1|7613589_7614969_-|CoA-transferase
MTDIKLAWSAVGGDPALVSRVSTVVREGAWQGRLPVRALARACVGACALAAAELGARRAGLSEVPAVRVDDGAVATAFLSERHLAIDGRAPVTFAPLSRFWRTADGWVRTHANYPHHRARLLDVLGVPQDVAAVEAALAERPALEVEEAVYAAGGLAVALRTPEEWAAHEQAAALAGRPLVERELLDSAPARVLAPLDTAGAPLLPAAGLRVLDLTRVIAGPVATRTLALLGADVLRVDAPQLPELPDQHADTGFGKRSTTLDLATDRRTFEDLLAAADVVVTGYRPGALDRFGLSARSLAERRPGLVVAQLSAWGASGPWAGRRGFDSLVQVATGIAAVEGSRERPGALPAQALDHGTGYLLAAAMLRALTEQSYDGGGRVVRLALARTARWLTEGVGTEEAETAGGASYDGAAPWLAETDSPLGRLRYARSPVSFAGGPTDWTRPPGPWGADERRWL
>NZ_CP022744.1|WP_067430069.1|7627649_7628354_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MSRSVLVTGGNRGIGLAIARAFADAGDKVAITYRSGEPPSGFLAVKCDITDTEQVEQAYKEIEAEHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVDTNLTGTFRVVKRANRGMLRAKKGRVVLISSVVGLYGSPGQANYAASKAALVGFARSLARELGSRNITFNVVAPGFVDTDMTKVLTDEQRAGIVSQVPLGRYAQPEEIAATVRFLASDDASYITGAVIPVDGGLGMGH
>NZ_CP022744.1|WP_067430066.1|7628359_7629127_+|enoyl-ACP-reductase-FabI
MSGILEGKRVLITGVLMESSIAFHAAKLAQEQGAEIILTAFPRPTLTERIAKKLPKPTKVIELDVSNDEHLARLADLVAEELGGLDGVVHSIGFAPQDALGGNFLNTPFESVATAMHVSAFSLKSLTMACLPLMQNGGSVVGLTFDAQYAWPQYDWMGPAKAALEATSRYMARDLGKQNIRCNLISAGPIGSMAAKSIPGFSDLAAVWDSRSPLEWDLKDPEPAGRGIVALLSDWFPKTTGEIIHVDGGLHAIGA
>NZ_CP022744.1|WP_067430064.1|7629292_7629646_+|hypothetical-protein
MRLSRSLASVTAAVCLVMSLPYDAMPHARVETRRAAAPEPFGASCHSRITGSQVTAYCHNPYPRTDGVRLHIECDRWWDLDSDGAQVRAGPAQTVRLTGRCWKEIRAVWVSHRKLAR
>NZ_CP022744.1|WP_067430062.1|7629620_7630316_-|FadR-family-transcriptional-regulator
MPLSHPRRSALSEQVIAALRTQITSGEWPVGARIPTEPELVEQLGVARNTVREAVRALAHNGLLDIRQGSGTYVVATSELAGVMHRRFADADPRHIAELRSTLESSAARLAAVRRTEKDLKQLDALLVRREEAWESGDTEAFVAADATFHLAVVAASHNDVMTEMYADLGEVLRDWLREDVGEELTPETHMDHARLVDAIRTGDAAAAAEEAASYPFLCRPGRFSEPASGG
>NZ_CP022744.1|WP_079164492.1|7630386_7631763_+|CynX/NimT-family-MFS-transporter
MMGLMAREETRTTQPTTVRTSATDPAVDVASDAQGDAQAAAMRAPRAWVVRLVVVAIVLSALNLRPAITSLGALLEEVRDGLGMSGGVAGLLTSMPPLCFALFGGMAPRLARRFGPSAVVCAGMLAITAGLLIRPYAGSTAGFLAASALALMGIAVSNVLMPVIVKRWFPDRVGSMTGLYSMAVALGTAAAAAVSVPMTDALGGNWQSGLALWAVLAAVAVVPWVPLLRDRGAAPDARGAASTAAKAPASSAGRTPAREEAAAPVRITRSRTAWALAVFFGLQATAAYITMGWMAQIFRDAGVPASTAGLLLAVTMVMGVPLAFVIPRLASRLPHQGPIVVALGVCGLAGYAGLYAAPAAGAWAWALLLGIANCAFPLALTMVGMRARTGVGVAQLSAFAQSTGYLISIPGPILVGVLYQSSGGWGLPIALMTGLMIPQMVVGVLAGRNRTVEDEAAR
>NZ_CP022744.1|WP_067430055.1|7632104_7632311_+|hypothetical-protein
MSAPTQTPPHPASRGGVDIRLPWWALALPTLAFVVLLALILNPSDAHAATGDPAVTRLLQHLQQLIAG
>NZ_CP022744.1|WP_067430053.1|7632376_7632895_+|histidine-phosphatase-family-protein
MSVAEPRRIVLFRHAKADWPQVTDHERPLADRGRKEAAEAGRRLTDTGLSLDLALCSTATRTRETWKLAVQEFPHRPKTVYEERIYEASPGELIALLNETPDDAQNVVLVGHNPGIQGLADILAGSAEGDARDRMSGRGFPAAAFAVLSFSGSWKALEPGVATLLEYWAPSD
>NZ_CP022744.1|WP_067430052.1|7632969_7634196_-|phosphoserine-phosphatase-SerB
MSASQTSIAASISDVPTLLVKIFGKDRPGITAGLFDTLAAFSVDVVDIEQVVTRGRMVLCALVTAPPRGLEGDLRSTVHSWAESVKMQAEIISGRGDNRPRGLGRSLVTVLGHPLTAEATGAVAGRITRTGGNIDRIFRLAKYPVTAVEFAVSGVETEPLRTALVTDAAKLGVDVAVVAAGLHRRAQRLIVMDVDSTLIQDEVIELFAAHAGCEAEVAEVTAAAMRGELDFEQSLHARVALLKGLDASVVDKVRSEVRLTPGARTLIRTLKRLGYQVGVVSGGFTQVTDDLKDRLGLDFAHANTLEIAEGRLTGRVTGEIVDRAGKARLLRRFAAEAGVPLAQTVAIGDGANDLDMLNAAGLGVAFNAKPVVREAAHTAVNFPFLDTVLYLLGVTREEVEAADMHDED
>NZ_CP022744.1|WP_067430049.1|7634376_7636404_-|hypothetical-protein
MSASMSVGAAKPGTRLPWGDILLSAIAAVSWALIGMAGTAALGLHLLGADTTASLGPMTAAVVALGAGGSVTPSGDVSAFGLSGAQAATAIEITPLGVGLVGALLLSWFFLRSLRTAGVVIAPSELLARAGAVIALFVAMLGGLAWAGHDVITIDGSALGLDDLPGGSGGGGVEIPGVGDIGDIGGLLPDRIGDLVDAQAAVGFTVDTAPTLLGGLGWCAGVLLIALLASRRTPLPHGWEAVHRVVRPAASALVTVLLMAVAAGFAAAAYAAIGDDNPKRIAGAALLGAPNGVWLGIPIGLFVPFDGRATGVLTNFLPDPLDRLLNSESDQSVTLGRLAELDGRVWLLGIGAAMMMLLAGVLTAVRTPVAEPARSGARPGARPGAVVRDPGAVRFAGRCALRLGVATALAMPLLAWLTEVAVDASLSVLGFNAFGAGIKLDGNLGMALLLGALWGAVAGAAGALLARATGAAGQRTAALALGDVGAGAPGRGSGWSAEGAGEGGLGAGGVGGAVGPGYGGGAGVGPPGGGARGSQSGPYSSGSSYRPPNPATNPYLRMPEGIVREPEDARPPGAEQARGGAGSSGEARSASRDARSAEEASSWPDVSQSPGDGMYGAPTVARPVDPPPRSPHGPGRMPEEDGPSSGSNQPAKRRRPPPPPPSPPPPAPRGPKGRR
>NZ_CP022744.1|WP_067430046.1|7636643_7639166_+|FHA-domain-containing-protein
MPELVLESNGRTWTLDPSRSYTLGRDPQGDVVLDDARVSWRHATISFNGRSWVIEDHGSTNGTFVQGQRIHQLEIGPGASVNLGNATDGPLVGLTGAAAAVASPQAQPQQQPYAAQGANPGWAQQAPPQQAAPQAGWQQPQQAHQPAPIPQQQGPGGGAGAPPVYGDRSPTTFHQFALGRVMRIGRALENELVVSDLQVSRHHAEFHATPDGRFEIRDLGSHNGTYVNGQPIAKGGSQLLGPNDIVGVGHSTFRLVGDRLEEFVDTGDISFSARHLTVTVDGGKQILKDVSFGVPEKSLIAVIGPSGSGKSTLLKALTGYRPANQGDVLYDNRNLYKQFAELRQRIGLVPQDDILHKELTVKKALKYAAKLRFPADTTGAERDARIDEVLRELKLDIHKDKKVTSLSGGQRKRVSVALELLTKPSLIFLDEPTSGLDPGMDRDVMQLLRGLADDGRTVLVVTHSVAELAICDKLLVMAPGGSVAYFGPPEEALNFFGYDTWADVFSAFENYRDYDWAGRWKGSQHYQMYAADIDAVAPQSVQMPPMQAMRPPKPQGWMSQFTTLVRRYVSVIASDKGFLALTVILPLVLGSVSLLIDSGKDLLVNTEINPVTGKPVANGTALTVLLILAVGACFAGAANSVRELIKERVIYERERATGLSRSAYLMSKVFVLGVVTVLQGLMVGVIGFSSRTIPDQGLILGSQTLLELCIPIMALGFTAMMFGLIISALVKTAEKTMPLLVMFAIVQVVFTGCLFPLANSVGVNELSYLMPSRWAVAAAGATLDFNRISPPAKGDSNDPLWEHTVGAWGMDMAALIAIGVVCGFFVARFLRRHEPEVMRK

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Crispr_ID: NZ_CP022744_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022744_4

8598026-8598113

Orphan

Consensus_repeat	Method
GCCGTCCCGATCCCCCACCCACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022744_4

>merge|NZ_CP022744|4|8598026-8598113|CRISPRCasFinder
GCCGTCCCGATCCCCCACCCACCCGTCCTTTTCAGCCCGTCCGGCGTCTGAGGCCGGGGCTCTCGCCATCCCGATCCCCCACCCACCC

>NZ_CP022744|4|4|8598026-8598113|CRISPRCasFinder
GCCGTCCCGATCCCCCACCCACCC	GTCCTTTTCAGCCCGTCCGGCGTCTGAGGCCGGGGCTCTC
GCCATCCCGATCCCCCACCCACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022744.1\|WP_067442964.1\|8608049_8609294_+\|DUF2817-domain-containing-protein	unknown	unknown	gnl\|CDD\|349461
NZ_CP022744.1\|WP_067446134.1\|8591737_8592118_+\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|377256
NZ_CP022744.1\|WP_079165219.1\|8588013_8589039_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|226855
NZ_CP022744.1\|WP_067442956.1\|8594529_8595744_+\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|236197
NZ_CP022744.1\|WP_067442961.1\|8601681_8603148_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|185009
NZ_CP022744.1\|WP_067442962.1\|8603396_8604299_+\|adenosine-kinase	unknown	unknown	gnl\|CDD\|238573
NZ_CP022744.1\|WP_067442966.1\|8611096_8612050_-\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|334462
NZ_CP022744.1\|WP_114604672.1\|8592236_8593367_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP022744.1\|WP_067446138.1\|8606097_8608053_+\|Xaa-Pro-dipeptidyl-peptidase	unknown	unknown	gnl\|CDD\|235435
NZ_CP022744.1\|WP_067442954.1\|8590465_8591644_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|225807
NZ_CP022744.1\|WP_067442958.1\|8598309_8599938_+\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|223107
NZ_CP022744.1\|WP_067442965.1\|8609382_8611083_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP022744.1\|WP_067442957.1\|8595785_8597960_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236864
NZ_CP022744.1\|WP_067442955.1\|8593363_8594506_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173849
NZ_CP022744.1\|WP_067442952.1\|8589092_8589422_+\|plasmid-stabilization-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067442963.1\|8604405_8605902_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066
NZ_CP022744.1\|WP_170068294.1\|8590294_8590441_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067442953.1\|8589522_8590233_+\|endonuclease-V	unknown	unknown	gnl\|CDD\|377374
NZ_CP022744.1\|WP_067442959.1\|8600032_8600740_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP022744.1\|WP_067442960.1\|8600716_8601442_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197716

Protein	Function_ID	Function_description	E-value
NZ_CP022744.1\|WP_067442964.1\|8608049_8609294_+\|DUF2817-domain-containing-protein	gnl\|CDD\|349461	cd06242, M14-like, Peptidase M14-like domain; uncharacterized subgroup. Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. Two major subfamilies of the M14 family, defined based on sequence and structural homology, are the A/B and N/E subfamilies. Enzymes belonging to the A/B subfamily are normally synthesized as inactive precursors containing preceding signal peptide, followed by an N-terminal pro-region linked to the enzyme; these proenzymes are called procarboxypeptidases. The A/B enzymes can be further divided based on their substrate specificity; Carboxypeptidase A-like (CPA-like) enzymes favor hydrophobic residues while carboxypeptidase B-like (CPB-like) enzymes only cleave the basic residues lysine or arginine. The A forms have slightly different specificities, with Carboxypeptidase A1 (CPA1) preferring aliphatic and small aromatic residues, and CPA2 preferring the bulky aromatic side chains. Enzymes belonging to the N/E subfamily enzymes are not produced as inactive precursors and instead rely on their substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages. They contain an extra C-terminal transthyretin-like domain, thought to be involved in folding or formation of oligomers. MCPs can also be classified based on their involvement in specific physiological processes; the pancreatic MCPs participate only in alimentary digestion and include carboxypeptidase A and B (A/B subfamily), while others, namely regulatory MCPs or the N/E subfamily, are involved in more selective reactions, mainly in non-digestive tissues and fluids, acting on blood coagulation/fibrinolysis, inflammation and local anaphylaxis, pro-hormone and neuropeptide processing, cellular response and others. Another MCP subfamily, is that of succinylglutamate desuccinylase /aspartoacylase, which hydrolyzes N-acetyl-L-aspartate (NAA), and deficiency in which is the established cause of Canavan disease. Another subfamily (referred to as subfamily C) includes an exceptional type of activity in the MCP family, that of dipeptidyl-peptidase activity of gamma-glutamyl-(L)-meso-diaminopimelate peptidase I which is involved in bacterial cell wall metabolism.	2.29352e-78
NZ_CP022744.1\|WP_067446134.1\|8591737_8592118_+\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|377256	pfam04237, YjbR, YjbR. YjbR has a CyaY-like fold.	4.44538e-15
NZ_CP022744.1\|WP_079165219.1\|8588013_8589039_+\|oxidoreductase	gnl\|CDD\|226855	COG4447, COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only].	4.8611e-19
NZ_CP022744.1\|WP_067442956.1\|8594529_8595744_+\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|236197	PRK08242, PRK08242, acetyl-CoA C-acetyltransferase.	0
NZ_CP022744.1\|WP_067442961.1\|8601681_8603148_+\|amino-acid-permease	gnl\|CDD\|185009	PRK15049, PRK15049, L-asparagine permease.	0
NZ_CP022744.1\|WP_067442962.1\|8603396_8604299_+\|adenosine-kinase	gnl\|CDD\|238573	cd01168, adenosine_kinase, Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway. .	1.9982e-56
NZ_CP022744.1\|WP_067442966.1\|8611096_8612050_-\|FAD-binding-oxidoreductase	gnl\|CDD\|334462	pfam01266, DAO, FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	4.98722e-27
NZ_CP022744.1\|WP_114604672.1\|8592236_8593367_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	3.65858e-114
NZ_CP022744.1\|WP_067442954.1\|8590465_8591644_-\|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	4.28865e-55
NZ_CP022744.1\|WP_067442958.1\|8598309_8599938_+\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	1.01961e-128
NZ_CP022744.1\|WP_067442965.1\|8609382_8611083_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP022744.1\|WP_067442957.1\|8595785_8597960_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	1.26184e-149
NZ_CP022744.1\|WP_067442955.1\|8593363_8594506_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	0
NZ_CP022744.1\|WP_067442963.1\|8604405_8605902_-\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.68844e-159
NZ_CP022744.1\|WP_067446138.1\|8606097_8608053_+\|Xaa-Pro-dipeptidyl-peptidase	gnl\|CDD\|235435	PRK05371, PRK05371, x-prolyl-dipeptidyl aminopeptidase; Provisional.	0
NZ_CP022744.1\|WP_067442953.1\|8589522_8590233_+\|endonuclease-V	gnl\|CDD\|377374	pfam04493, Endonuclease_5, Endonuclease V. Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents.	8.5985e-102
NZ_CP022744.1\|WP_067442959.1\|8600032_8600740_+\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.54583e-66
NZ_CP022744.1\|WP_067442960.1\|8600716_8601442_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|197716	smart00422, HTH_MERR, helix_turn_helix, mercury resistance.	7.06393e-18

>NZ_CP022744.1|WP_067442957.1|8595785_8597960_+|enoyl-CoA-hydratase/isomerase-family-protein
MTQSTTIRWEQDRSGVVTLVLDDPDQSANTMNQAFRDSLAVITDRLEAERDTIRGVIITSAKKTFFAGGDLRDLIRVTPDTAQDLFDGGLAIKRNLRRIETLGKPVVAALNGAALGGGYEIALACHHRIALDAPGSKIGCPEVTLGLLPGGGGVVRTVRLLGIADALLKVLLQGTQYSPQRALENGLVHDVAATQEELLAKARAFIEANPESQQPWDKPGYRIPGGTPAHPKFAANLPAFPATLRKQTNGAPYPAPRSILAAAVEGAQVDFETAQVIEARYFVELAAGQTSKNMIQAFFFDLQAVNSGANRPKGIEPRPVRRVAVLGAGMMGAGIAYSCARAGIDVVLKDVSLEAAVKGRGYSEKLCAKAVSRGRTTQEKADALLARITPTADPADLAGCDAVIEAVFEDTALKHKVFQEIQHVVAPDALLCSNTSTLPITALAEGVERQGDFVGLHFFSPVDKMPLVEIIKGERTGDEALARAFDLVRQIRKTPIVVNDSRGFFTSRVIGHFLNEGVAMVGEGVEPASVEQAAAQAGYPAKVLSLMDELTLTLPRKIRRETRRAVEEAGGTWTAHPAETVIDRMVDEFDRPGRSGGAGFYDYDESGRRTTLWPGLRDHFTRPGTEIPFRDMQERMLFAEALDTVKLLEEGVLTSVADANIGSIFGIGFPGWTGGVLQYINGYDGGLPGFVTRAHELATLYGDRFTPPALLVEKAEKGETFKDA
>NZ_CP022744.1|WP_067442956.1|8594529_8595744_+|acetyl-CoA-C-acetyltransferase
MSTEAYVYDAIRTPRGRGKANGALHGTKPIDLVVGLIHEIRDRFPGLDPAAVDDIVLGVVGPVGDQGSDIARIAAVAAGLPDTVAGVQENRFCASGLEAVNMAAAKVRSGWEDLVLAGGVESMSRVPMASDGGAWFNDPMTNLNVNFVPQGIGADLIATIEGFSRRDVDEYAALSQERAATAWKEGRFERSVVPVKDRAGLVVLDHDEHMRPGTTADSLAKLKPSFADIGDLGGFDAVALQTYHWVEKIDHVHHAGNSSGIVDGASLVAIGSKEIGERYGLTPRARIVSAAVSGSEPTIMLTGPAPATRKALAKAGLTIDDIDLVEINEAFAAVVLRFVKDMGLSLDKVNVNGGAIALGHPLGATGAMILGSLVDELERQDKRYGLATLCVGGGMGIATIVERV
>NZ_CP022744.1|WP_067442955.1|8593363_8594506_+|acyl-CoA-dehydrogenase-family-protein
MKRQIFAPEHDAFRETVRGFLAREVLPYYEQWEKDGIVSREAWRAAGKQGLLGLAVPEEYGGGGTRDFRFSAVLAEEFTRAGAPGLALGLHNDIIGPYLTGLATDEQKRRWLPGFCDGSLITAIAMTEPGAGSDLQGIRTHAEDRGDHWLLNGSKTFISNGILADLVIVVARTTPEGGAHGLSLFVVERGTEGFERGRNLDKIGQKAQDTAELFFHDVRVPRENLLGEFNGAFVHLMTNLAQERLSIAVSAIAAAEHLLEITTRYVKEREAFGRPLATKQHIRFEVAEMATECAITRTFLDRCIADHSDGTLDAVHASMAKWWATELQKRVADRCLQLHGGYGYMTEYPVARAFTDGRIQTIYGGTTEIMKEIIGRSLLG
>NZ_CP022744.1|WP_114604672.1|8592236_8593367_+|CoA-transferase
MATTPGQGPLSGVRVVELAGIGPGPFAAMLLADLGADVVRVDRPGGPGLAIDPRFDVTNRNKRSVLVDLKAPEGPARVLDLAARADILVEGYRPGVAERLGVGPEACHARNPGLVYGRMTGWGQQGLLAERAGHDIAYIALTGTLGMVGEPDRPPAAPANLLGDFAGGSLYLVVGVLAALHHARATGTGQVVDAAIVDGTAHLSAMLHGMMAAGGWQDRRAANLLDGGCPYYGTYETADGRYMAVGALEPRFYDEFVTLLGLTGFADARKDWTRWGELREAVAARFRSRTRQEWTAVFEGTDACVAPVLSLREAPHHPHLAARGTFTDHGGITQPAPAPRFSATPTTVSGGPALPGADTAEVAREWDVPDLTKGPE
>NZ_CP022744.1|WP_067446134.1|8591737_8592118_+|MmcQ/YjbR-family-DNA-binding-protein
MAVPRNALRKWEKVREFALGMPGATEEFPWGETVAKVNRKVFVFLGVDDGSYPLGVTVKLKDEAAHAHALTCPGAEPAGYGLGKSGWVSIPLEQKGAPAAELLCDWVEESYRAIATKRFVAELDAR
>NZ_CP022744.1|WP_067442954.1|8590465_8591644_-|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MNRPSRTDRPYDIVLFGATGFVGTLTAEYLAAHAPEGLRWAIAGRSEEKLERLRERLPGGAEIGVLRADVSDPASLRALAEHARVVATTVGPYVAYGDDLVAACADTGADYLDLTGEPEFVDLTYVRHDTRARETGARLVHACGFDSVPHDLGAYFTVRQLPEGVPLRIDGFVTADATFSGGTFASALGQFARGRQMLAAARDRGHHEPRLVGRRATAPTGAPRFAPEVGAWALPLPTIDAQIVRRSARALERYGPDFRYRHYAAVRHLPVAVGSVAAVGALVAAAQVPPARRWLSGRLRPGEGPGPEKRAKSWFRVRFVGEGGGRRVCTEVAGGDPGYDETAKMFAESALSLALDDLPPTAGQVTTAAAMGDALTERLRRAGITFRVASER
>NZ_CP022744.1|WP_170068294.1|8590294_8590441_+|hypothetical-protein
MTSHRAPRPLADPNRPVERAVNAGLILATLAGLGWIVGMIYTLVQWPL
>NZ_CP022744.1|WP_067442953.1|8589522_8590233_+|endonuclease-V
MTTVRIPAGWPATEERARAVQDELRGRVVLDEPGPPPGTGRVTGVDVAYDDERDLVAAAAVVLDAASLTVVAEATAVGRISFPYVPGLLAFREIPTVLAALEALPGPPGLVVCDGYGLAHPRRFGLASHLGVLTGLPTIGVAKNPFTFAHEDPDAPRGSTSPLLAGTEEVGRALRTRDGVKPVFVSVGHRVSLDNACAHTLALSPDYRLPETTRRADALCRRALREAAQVSRSPAD
>NZ_CP022744.1|WP_067442952.1|8589092_8589422_+|plasmid-stabilization-protein
MPAGSSSKRERQYEHIKESAQDRGESTGRAKEIAARTVNKERARSGESKSASRTSTQDMSSGKRGGQRSGKGSQGPTYDQLYEEAKRRGVKGRSDMNKSQLQRALGGKS
>NZ_CP022744.1|WP_079165219.1|8588013_8589039_+|oxidoreductase
MAALTAVPAQAQTPPDRSPHWELKDTASPDVRFRGLAAVDRRTAWVSGTGGTVLRTTDGGASWRNVSPPGAAELQFRDIEAFDARRAVVLAIGEGEASRVYRTDDGGQTWTESFRNTDAKAFYDCLTFFDRRHGLAMSDPVDGKFRILSTGDGGRTWKVLPNTGMPAALEGEAGFAASGQCLVSSGPRDVWLATGGAARARVLHSADRGLTWTASDTPVPAGDPARGVFALAFRDRAHGLAVGGDYRPDRPSPQAAARTGDGGAGWRSATRPVPAYRSGVAWLPHSRTTALAVGPTGTDLTTDAGRSWRTVDQGSYDTVDCTPDLGCWAAGEQGRVARLER
>NZ_CP022744.1|WP_067442958.1|8598309_8599938_+|thiamine-pyrophosphate-binding-protein
MGHRPAAAVLDILRDEGVDKVFGNPGTTELPFLAALADAHNTPEYILGIHEGSVVAMADGYARATHRPAFVSLHIAAGLANGLIGLLNARRSRTPLVVTAGQQDRRHLQQDPMLSGDLIGLATPAVKAAYDIQHARDLPLALRRAFALAVRPPAGPVFLSVPMDLLDEDTEVEVPARTPPPPQGPAAGIERAAVLLGAATRPAIVAGDGVGREDALGALVRTAEACGATVHHQPMSDCLNFPTTHPLYAGMLPPRHDAIREALTAYDTVLIVGAHAFTPHHYTPGPALPPGLTVVQLDSDPDEIGRNFPATAGLVGALAPSLHRLADLLGDQVPAHTARSRTLRTGQRHTAERDRAESAARAAYSPAPLAPWAAAHAVARGLPPDAVVVEEAITMGLLLRRLVRLDAPGSYTHTVGGGLGWGIGAAVGRALAEPGRPVVAVLGDGCTLFGLQGLWSAARQSAPVLFVVMNNGVYRTLQDTYAARGGEGVCPGTDLGPLDFTQAARFFGVDAVRAESADQLRELVAGAGELTGPLLIDVPIRS
>NZ_CP022744.1|WP_067442959.1|8600032_8600740_+|SDR-family-oxidoreductase
METRTALVTGAAQGLGRQFAIALAARGYRVAGLDLVPQPETAARILDYVELVGDVGDETQIGEGLERVIDRFGTLHVVVNNAGVHPAKPFEETTVEDWRRVMRVNLDAPFLVTRAALPYLKAAGWGRVVNIVSTAVFTAPPTMVPYVASKTGLIGFTRALATALGPYGITVNAIAPGPVRTATAEHLRARQAVARTLEPTLEPSDLVSTLLYVVDEGSGFLTGQTLTVSGGSACL
>NZ_CP022744.1|WP_067442960.1|8600716_8601442_-|MerR-family-transcriptional-regulator
MTTEATDASEAGGPTLTIDELAARAGVTVRTVRFYGTKGLLPPPVIGPRRVGHYGGEHLARLALIEELQQQGMTLAAIERYLQQLPADLSPHDLAIHRAVVASWAPDVMETVTREELQRRAGRALSDDDVERLAAMDVVRREEAVFRVDLGLLRLGVRLLDVPLSQEAILASRKVLIEHSRAAAHELARLFRGEVSERDARDVKSLSADMEPLVVQALLTTFQRSLKEELREWSSQAGGSA
>NZ_CP022744.1|WP_067442961.1|8601681_8603148_+|amino-acid-permease
MSKDAVGSAQTAARTATAQVPADAGDAGYSKDLKARHVNMIAIGGAIGTGLFLGAGGRLDTAGPALALAYLVCGVFAFFVVRALGELVLYRPSSGSFVSYAREFLGEKGAYVAGWMYFLNWSTTGIADITAIALYTHYWSLFTDIPQWTLALIALAVVLAVNLISVKIFGEMEFWFAIIKVATLVGFMLIGIFLLATRHEVDGRTPGLSVITDNGGTFPHGLMPVVIVMQGVIFAYAALELVGVAAGETAEPEKVVPRAVNSIMWRVGLFYVGSVVLLALLLPGSVYSAGESPFVTVLSRIGVPAAGDVMNLVVLTAAMSSLNSGLYSTGRILRSMAMAGSAPRFTARMNRSQVPYGGILLTCAVCVLGVGLNYLMPSQAFEIVLNVASLGVISTWVIIMICHLVFVRRAKAGLLTRPSFRLPGSPVTEITTITFLLAVLALMANDPDVGRKTLLLIPLIALMLITGWFAVRHRVTRTTDQELTGFTD
>NZ_CP022744.1|WP_067442962.1|8603396_8604299_+|adenosine-kinase
MSRDTDVLVLGGAGVDTIVYVPELPLPYADSYLIDSGIRTRAGQTGDFVAVGLSALGLRTHHLDLLGDDPEGDLVRALHRDRGIELTAVSQPAGTKRAVNLVGPDGRRLSLYDTSRAHPDDRLPEATVRALAATSRHAHVSITQPCAHTLPVLRETGVTISTDLHNWDGENDYHEPFAHTADLVFLSATALPDPERTMRRIVEHGRAQTVVATAGAEGAYLLTDDTLTHIPPATPPAPVIDTNGAGDAFAAAYLYGHLNGEPPYRCAAYGTLAGAHACTIPSTETAAMTRTELLARTEAP
>NZ_CP022744.1|WP_067442963.1|8604405_8605902_-|M1-family-metallopeptidase
MHRRILAPGALAAASLLLAIPASAASSAPGAPGIGDPYYPAYGNGGYDVSHYDLRLRYQPATDRLEGTTTLLARTTEDLSRFNLDFLLDVSEVRVNGAKASFTTSGEHELEITPKTPLAKGTAVTVVVRYSGVPSTKEAYGFNAWLRTPDGGVAAGEPEGAWWWFPSNDHPLDKATFDVSVQVPDGHQAISNGTLQSTSSRAGWTRYNWRSNKPQTTYLATLAVGRFDVTTGTSESGIPVINAYSKDLGDSDGAARASVERTGEVADWLTEYFGPYPYNALGGYVPNTPQVGYALETQTRPFYSPRQFANGSNVSVVVHELAHQWYGDEVSVEHWKDIWINEGFARYAQWLWSEHEGEGTTQEIADYVYASRPADDPFWTVKPGDPGPENQFHISVYDRGALAVQALRNEVGDAAFFAILKGWPTEYAHGNASVGDFQRYAEEVSGQPLAGLFDTWLFQPVKPAAPAARSASIAAVPGVPEQPKSWKKIAATNDVHEH
>NZ_CP022744.1|WP_067446138.1|8606097_8608053_+|Xaa-Pro-dipeptidyl-peptidase
MPTRMRFTTWRQLAVVAVAALTAALLTPAAAHGTPRESRPVYSYDNAVREAVWVDTGLDGDGDGRTDRVAADIVRPREPAQQGRKIPVIMDASPYYSCCGRGNESQLKTYDADGDVVQMPLFYDNYFVPRGYAFVGVDLAGTNRSDGCVDVGGRSDIQSAKAVVDWLNGRAKGYTTRTGGKQTKATWTNGRTGMIGKSWDGTIANGVAATGVKGLKTIVPISAISTWYDYYFSEGAPLYDSGPDWLSDYVDSPDARAKCGAVQQRIVDGAPRTGDLTPFWSERDYVKAASKVRASVFLIHGMQDLNVRMQHVGPWWDALAKNGVERKIWLSQTGHVDPFDFRRTAWVDTLHRWFDHELLGYDNGIDREPMADVERHPDQWTTSKMWPPAGTAATTLRPAEGTREGVGRLGLRPGTGTETFTDDPKLSETDWAARIDTATPDKAGFTTGPLTKDLRLSGSSKVTVTATPTTSTAHLSAVLVDLGPDTIRDYGASGEGITTLTDRTCWGASTTGDSACFKETAAKTTDVDFTVVSRGWADLGNHADPGKGAPLTPGKAYTITLDLGATDHVVPAGHRLALIVAGTDKDLIDPPSTTPTLTVDLTRTSARVPFVGGIAAFARATAGSPAVAPEATRLDGVTTPRTTQRIPGEAR
>NZ_CP022744.1|WP_067442964.1|8608049_8609294_+|DUF2817-domain-containing-protein
MIRALTLTTAALAASLVAVPAAATEAPPRTGFEQTNGARWTTQPEEQDFLAAVDRASTRVSVGSLGTTKQGRPLQLVRVGARHAPNTVLLVCGQHGDEPSGREACLTTIRDLAYAKDRPTRRLLERTTVLVVPTANPDGRAADTRGNSDGVDINRDHLALQTLEGRALAAVIRDRRPDLIYDLHEYGSTPPYYDKDLFDLWPRNLNTAPAVHDEAETLSQAYVRPAARGAGYTTGTYGIWTDPVTGEPIRQVAGDGQERILRNMSGIKHAIGLLIESRVEPLTGTDEPANNRRRVDSQLAALKGLFAYTDERRTQVERATDAARRAGWTDTGPVYVGGADNDPPEPAEVIQDPPCGYRLTAGQYAEIKDELALHGVRTHGTHVPLRQPLRALVPLLLDERAPYHLTAAEPDTAC
>NZ_CP022744.1|WP_067442965.1|8609382_8611083_+|BCCT-family-transporter
MTEDLKKRGGREGASSPPGRSTDRVVFGVTAAITVAFVIWGAAGTDSLESVSTKMLNGLIHNGGWAFMLAASCFVVFALWIAASRYGRIHLGAEGEEPEFKTVSWVAMMFSAGMGIGLMFYGVSEPLSHYTTPPPGTTPANSGERMETAMATTLFHWTLHPWAIYAVVGLAIAYSTYRKRRRQTISAVFTPLIGEKHANGAGGRVIDILAIIATVFGSAASLGLGALQIGSGFQELDWMDDVSTGLLVAIIAVLTLAFVASAVSGIERGIQWLSNTNMVLALVLALFVFVAGPTIIVLDLLPTSVFAYLGDLPQLAGRTEASGGAGVADWLGSWTVFYWAWWISWTPFVGMFIARISRGRTIRQFVGGVILVPSTVSLVWFAVFGGSAMRLREGGALRGESTPEGQLFGLLQEFPIATVTSLLVMILVGIFFVSGADAASIVMGTLSQKGALEPGRFVVVFWGVVTGAVAAIMLLVGSGQGDALTGLQNLTILAAAPFVLVMIGMCVALMRDLRQDPVIVRGEMGSEAVELAVIEGHKRYDGDFEIRVGPGAGTETEGDPLGHDHT
>NZ_CP022744.1|WP_067442966.1|8611096_8612050_-|FAD-binding-oxidoreductase
MNSGLGDEIVVVGGGVVGLTTAVVLAERGRRVRVWSRDPVEGTTSAVAGALWWPYHIEPVALARAWALRSLDVYEELAARPEETGVRMVEGVLGEADPDAADAWVTDRLPGLRATTAEEYAGTGTWVRLPLIDMPAHLPWLRDRFVAAGGTIEARTVADLAEVDAPVVVNCTGLAARELVPDPSVRPVRGQLVVVENPGIHTFVVSTDADGEMAYFFPQPGRLLLGGTAVEDEWSTEPDPVTAAAIVRRCAALRPEIAGARVLEHRVGLRPARDAVRLEREPLSGGRVLVHNYGHGGAGVTVAWGCAEEAAGLAASP

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Crispr_ID: NZ_CP022744_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022744_5

9178676-9178780

Orphan

Consensus_repeat	Method
GGAGGACACCTGGAAGCCGTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022744_5

>merge|NZ_CP022744|5|9178676-9178780|CRISPRCasFinder
GGAGGACACCTGGAAGCCGTCCGGAGCCGTCTGGGCGCAGCCGCCGGGGCACTGCGGGGTGGCTGTGCCGGGGTCCCTCAGGGAGGAGACCTGGAAGCCGTCCGG

>NZ_CP022744|5|5|9178676-9178780|CRISPRCasFinder
GGAGGACACCTGGAAGCCGTCCGG	AGCCGTCTGGGCGCAGCCGCCGGGGCACTGCGGGGTGGCTGTGCCGGGGTCCCTCAG
GGAGGAGACCTGGAAGCCGTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022744.1\|WP_067443418.1\|9187374_9188403_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187551
NZ_CP022744.1\|WP_067443406.1\|9169029_9170061_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067443405.1\|9166983_9167712_+\|DUF2470-domain-containing-protein	unknown	unknown	gnl\|CDD\|378456
NZ_CP022744.1\|WP_079164963.1\|9172966_9175891_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
NZ_CP022744.1\|WP_067443409.1\|9176047_9177064_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP022744.1\|WP_067443404.1\|9166225_9166834_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP022744.1\|WP_067443408.1\|9171544_9172924_+\|erythromycin-esterase-family-protein	unknown	unknown	gnl\|CDD\|350610
NZ_CP022744.1\|WP_067443419.1\|9188470_9189139_+\|M15-family-metallopeptidase	unknown	unknown	gnl\|CDD\|350618
NZ_CP022744.1\|WP_067443416.1\|9185667_9186957_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP022744.1\|WP_067443414.1\|9181345_9184513_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|99802
NZ_CP022744.1\|WP_182449333.1\|9180526_9181177_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|312075
NZ_CP022744.1\|WP_079164964.1\|9177064_9178549_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066
NZ_CP022744.1\|WP_067443411.1\|9179061_9179568_-\|FBP-domain-containing-protein	unknown	unknown	gnl\|CDD\|379860
NZ_CP022744.1\|WP_067443420.1\|9189142_9189832_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067443417.1\|9187035_9187350_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022744.1\|WP_067443415.1\|9184587_9185586_+\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|366736
NZ_CP022744.1\|WP_067443403.1\|9164600_9166118_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|365848
NZ_CP022744.1\|WP_067443407.1\|9170121_9171369_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP022744.1\|WP_067446285.1\|9167679_9168906_-\|lactonase-family-protein	unknown	unknown	gnl\|CDD\|378416
NZ_CP022744.1\|WP_067443412.1\|9179618_9180623_+\|DUF3626-domain-containing-protein	unknown	unknown	gnl\|CDD\|372019

Protein	Function_ID	Function_description	E-value
NZ_CP022744.1\|WP_067443418.1\|9187374_9188403_-\|SDR-family-oxidoreductase	gnl\|CDD\|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.82105e-98
NZ_CP022744.1\|WP_067443405.1\|9166983_9167712_+\|DUF2470-domain-containing-protein	gnl\|CDD\|378456	pfam10615, DUF2470, Protein of unknown function (DUF2470). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	1.11125e-08
NZ_CP022744.1\|WP_079164963.1\|9172966_9175891_-\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.7016e-87
NZ_CP022744.1\|WP_067443409.1\|9176047_9177064_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.40609e-20
NZ_CP022744.1\|WP_067443404.1\|9166225_9166834_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.80669e-11
NZ_CP022744.1\|WP_067443408.1\|9171544_9172924_+\|erythromycin-esterase-family-protein	gnl\|CDD\|350610	cd14728, Ere-like, Erythromycin esterase and succinoglycan biosynthesis related proteins. This group contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides act by inhibiting bacterial protein synthesis by binding at the exit tunnel of ribosomal subunit 50s, blocking the translation of the polypeptide. Erythromycin esterase, typically found in integrons and transposons, confers antibiotic resistance through the disruption of the drug ring structure. EreB substrate profile is substantially broader than that for EreA, being able to also metabolize semisynthetic derivatives such as azalide azithromycin.	7.46497e-103
NZ_CP022744.1\|WP_067443416.1\|9185667_9186957_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	5.18548e-52
NZ_CP022744.1\|WP_067443414.1\|9181345_9184513_+\|cytochrome-P450	gnl\|CDD\|99802	cd06206, bifunctional_CYPOR, These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via FAD and FMN. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	3.27102e-138
NZ_CP022744.1\|WP_182449333.1\|9180526_9181177_-\|PAS-domain-containing-protein	gnl\|CDD\|312075	pfam08448, PAS_4, PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.	1.69411e-06
NZ_CP022744.1\|WP_079164964.1\|9177064_9178549_-\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	3.76979e-138
NZ_CP022744.1\|WP_067443411.1\|9179061_9179568_-\|FBP-domain-containing-protein	gnl\|CDD\|379860	pfam16571, FBP_C, FBP C-terminal treble-clef zinc-finger. FBP_C is a family from the C terminal end of fibronectin-binding proteins. It forms an extended four-cysteine zinc-finger with a unique structural fold. Fibronectin-binding proteins bind to elongation factor G - EF-G, which is mediated by the zinc-finger binding to the C-terminus of EF-G. FBPs release ribosomes by competing with them for EF-G.	3.43629e-87
NZ_CP022744.1\|WP_067443419.1\|9188470_9189139_+\|M15-family-metallopeptidase	gnl\|CDD\|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	2.35051e-64
NZ_CP022744.1\|WP_067443415.1\|9184587_9185586_+\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	1.25116e-20
NZ_CP022744.1\|WP_067443403.1\|9164600_9166118_-\|cytochrome-P450	gnl\|CDD\|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	8.17382e-72
NZ_CP022744.1\|WP_067443407.1\|9170121_9171369_-\|FUSC-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	3.65027e-11
NZ_CP022744.1\|WP_067446285.1\|9167679_9168906_-\|lactonase-family-protein	gnl\|CDD\|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	2.77341e-136
NZ_CP022744.1\|WP_067443412.1\|9179618_9180623_+\|DUF3626-domain-containing-protein	gnl\|CDD\|372019	pfam12294, DUF3626, Protein of unknown function (DUF3626). This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 374 amino acids in length.	2.00716e-75

>NZ_CP022744.1|WP_079164964.1|9177064_9178549_-|M1-family-metallopeptidase
MSPDTRPRRGLRLTLAAAIAMTAALTAPAAGAAPATSRDSVPVPGAPGLGDPLFPLDGNGGYTVDRYLLDFDWQAPKTPFRAKATIRATATTELSRFNLDFAGNTLHEVTIDGTPAEAVREGDELIVTPWLPLPRKSTFTVTVTYTADPTQIRHRDDAIEDYGWIPTPSGTVLYPQPNGAKMVFPANDHPSQRAPVTFRVTAPTGLTAVANGRLVSREPLTGGRERWTYDSEQPVSTQLVQMAVGRLTAVDRPTTNGVPLRDFVPDELVDRTDEYLDLTPQHLRWLEQRLGAYPFKRYGVLVGDTDLGVALETQTLSLVPKADLLGTRVDAERTLVHELVHQWFGDSVALRTWSDLWLSEGHARFYERLYSEEHGGDSFEAAMKTAYTNHNLWRRDFGAPAEPTEPNLFKRMRYDGSALVLYALREKVGDETFRKIDRAWVTKYRGRTASTQDFMDLASAVSGQDLASFLRPWLYGPTTPPMPNHPDWVATPVP
>NZ_CP022744.1|WP_067443409.1|9176047_9177064_+|LysR-family-transcriptional-regulator
MELRDVETFLEVARVLHFGRAAERLHVSQGRVSQIIKGLEREVGGALFERSSRRVRLTPLGERFRTGAAEGHDRLTATLRECRAVARQVGDRLRIGYQWTMGGELTDRLVSGFTRAHPHCEVVVSSLVFRAGGNLVPLAGGTDVDLVLRWSPGGDGSAVEAPGLVVGPLLAAVPRGVLVPAAHPLAGRRAIVLDDLLPYELLRLPDALGAPLRERWVPTHTSSGRALRHTDEDMSRLMGTEHLPVEDVLALVAQGRALHLTIAGLLDRVPFPGLAVVPVLDMPPMVVVPVWRAARENATIRAFVESAARTTEAERAVVTREAASVRTSVVRSVREAAR
>NZ_CP022744.1|WP_079164963.1|9172966_9175891_-|hypothetical-protein
MPRGERPLKAGDARIVAFAAELRRLRNKAGSPTYRQLAERAHYSVSTLSGAASGKVLPTLAVTLAYVRACDGDVAHWERAWHALAAELGAAAEASDADSSDGPAPYVGLAAYQTSDAAWFFGREGLVEELVRRLRQQRLLLVVGASGSGKSSLLRAGLVPRLAPGATPVVFTPGTRPMEECAVRLSAAANLTPGRVYRELLDDPANLGRLARQIGARSDAADSEVVLVVDQFEELFTHCAPAERDHFITALLTAATADGNRCRVVIGVRADFYTHCTHHPGLVAAMRDAQIPVGPMDLEDLRRAVVQPAVRAGLTVEGALLTTLATQALGQAGVLPLLSHALRETWRRRRGNALTLDAYRATGGLEGALARTAEEFYAELGAERQKLARQVFVRLTALGEGTEDTRRRVPLGELARLGTPAGAVEDTGRGPAMGEDVGAVLEGAARARLVTLDQDRVELTHEALIRCWPRLHGWLTEGREQLRVLRQLTEAARTWESLGRDPDALFRGARLALAREVEDQVLSSEERTFLDASAAAERAESARGRRRARQMRRLTALLAVLLAVAVTAAVLALRARDELTRERNKVLAREVAVDAVALRQDRPALAAQLGVAADRLSPSATTRDALLGVTAASLLGHEQAVSALAFRPDGRMLATAGYDYTVRLWDVTDPFRPVAVGEFAGGPDIMTAVAFSPDGRRLATGGRDRTVRLWDVTRPRRPAPVRVLTGHGDIVFSVAFSPDGRTLASGSYDHTVRLWDVSSAASGPVVLRGHRLNVKPIAFSPDGRTLASGSDDRTVRLWDVTSPRRPRPLAVLTGHRDFVDALAFSPDGRTLASGSDDRTVRLWSVADPRRPRTGTVLTGHTDVVSSVAFSPDGRLLASGSTDRTARLWDLPATGAPGLRSELTGHLGAVNVVAFRPGEGDAPLATGSSDHTAQIWQTDAAHAGRRACARARPVITRAEWNRWLPGIPYSPPCGD
>NZ_CP022744.1|WP_067443408.1|9171544_9172924_+|erythromycin-esterase-family-protein
MTWQRTGPSLTLLITLGVALPAGIPAAAATTAPTATTLPAAATASTQDVVAALDRAAHPLRTVEPGGDTGDLRPLDRMIGDARVVGLGEATHSSHEFFALKDRVFRHLVEEKGLRTFALEAPWSTGLRLDAYVLHGKGDPRRIMREEFQRDYLWWNNTDYLRLVEWMRAYNVRHPEDPVRFMGDDIAWSGPELYDAVSDHVAATHPGASARLAELYRGLRPTVATGTYIEEYLARPYAERKEMADRTGRALDLVRHLGPGTDRESYGRALQNATVIDQTARQYAWDLEDPAQIAEAMRYRDRAMAANVVWWQRHTGTKVLLSAHNNHVGYVPDDPVHYPKVQGAFLRDSLGAGYVSVGLTFHHGSFNATGQDDETVRRWTLGPPGPDSNERTLDRVRHRDHVLDLRTAGPPARDWLRQARPTRSIGTAYPELPDDIALARSHDVLIHLHSIGAARLRDR
>NZ_CP022744.1|WP_067443407.1|9170121_9171369_-|FUSC-family-protein
MRQVREGTASLRGFVKRHRDPVVVQALRSTAAATVAYVIALRFSPEAAPLTAPLTALLVVQVTLYSTLTTGIRRVNSVVAGVLVAIAFSLLVGLTWWSLALLIVASLAVGHLVRVDEFVPEVAISAMLVLGVTTVGDTAWARVLETLIGAVVGLGCNLLLAPPVWVGEAGESIEGLARRVRQLMLSMGEEAAGRTPVEHATERLHEARRLDHAIVEVDAALRQAEDSLRLNPRVREGLLHRVVLRTGLDTLEICTVVLRVLARTFTDLAKHRETESLFAPGTGAVVEQLLSEIADAIVSFAVLVTTHVSENADAAEARLTTELRQAAATRDKLAQLLLEEVQRDAGQWQLQGAVLTEVNRILDELDTEHRSHRLLEELDRTAREQRERMPRLTRLRENLKVPEPLRRNRADAGRR
>NZ_CP022744.1|WP_067443406.1|9169029_9170061_-|hypothetical-protein
MTDTGVRIDGNTLRLPGGVAVRFVRTLRLPETGTHPLPPGLGEFPVRRISDHADRVPERWRARGGVMLPVYLREAMWLSFAGTTEPAALQVGVGKVCAVSGRPWSDRLSRDPQNYLVLPRQPWLDGINSGKGTVRQFVAVPLGLGATVEGQVTGEETWGGVQLQTFPLNARELARWQEEERRRAERTRAFPQAAGYGAAMPMAASAPAAPAAAPRRAAAMGLGVGGSMRQEVYRDDRPVGDWSAEPAGRVFVHLVTPPEWRRITGEAPPPSPVDRAAYTRAGLPWFDYYDQDAEDLASTDTLEGVKPVGDWIGDDHEPWQEPSPQQVRPLKDAPGKPVEDGDW
>NZ_CP022744.1|WP_067446285.1|9167679_9168906_-|lactonase-family-protein
MGTGGWSRRRFVGALTGTAAAATLPACGDESTPSGASTPSAGSASATAPDTNERPQTEGRESSGSHPLYLGTYTSAEGGGKGIGLATYDSATGRVTDGGLLAETANPSFLAVHPNGRTLYAVNERDDGGVTAVRLADRRVLGTRSSAGAGPCHLSVHPSGRWLLSANYTSGSVTVHPIAASGALGEHTDVVTHSSPPPGPNSERQDGPHAHQIVTSPDGGHVLAVDLGTDTVYTYRLDQARGTLTEVSRASAKPGAGPRHLTFHPGGRYAYLANELDNTITVCAYDPATGRLTIGDPQPTGTGDVTSYPSQILVTADGSYAYLANRGHNSLTRYAVEAKGARVRLLDTVPVHGDWPRHTAFSPDGRLLFVANQNSGSVTVFHVDRASGELRLAGEPFASPVAVCALPL
>NZ_CP022744.1|WP_067443405.1|9166983_9167712_+|DUF2470-domain-containing-protein
MGDSQSWAAVPSAAERARSVLAAAWSCAVTAEGGREEFVGAHSVSDDGRVLLHVPEESTLLATAVCAPRGEPSAVLEFADVAPVPVRSRIRTRLWMAGWFTADEEGHLAFRPTRVVLREPSGAVVVGLDDFAAATPDPLATAEARLLTHLADCHADAVERLTRLVDSDSLHGAVRVQPLAVDRHGLTLRIERARAHGDVRLAFHRPADDVGQLTERMHVLLTRAGAASCPRTLQRQRTDGDG
>NZ_CP022744.1|WP_067443404.1|9166225_9166834_+|TetR/AcrR-family-transcriptional-regulator
MAANQGGRTRRRLSTEERREQLLTVGARLFSESPYDEVWIERVAEIAGVSRGLLYHYFPTKRDFFAAVVERESERMLRMTAAVPGIPVREQLGAGLDTFLEYVQAHAHGYRAFHRADAAGDQTVRRVYQRALAAQERQILAAVAADPEWSALSETRPDLRLAVRGWLAFTTAVCLEWLRGSDLTREQVRDLCARALLGVITP
>NZ_CP022744.1|WP_067443403.1|9164600_9166118_-|cytochrome-P450
MAERTPGTGRPRGFRSAELGWPELERLPHPPRRVPLLGDVLGVDRHSPLQDTVRHARRLGPIFRRKAFGREFVFTWGADLVADLADEARFAKHVGLGVANLRPVAGDGLFTAYNHEPNWQLAHDVLAPGFNREAMQGYHAMMLAVAGRLTDHWDRAQAAGLEVDVPGDMTKLTLETIARTGFGHDFGSFERARPHPFVAAMVGTLTYAQRLNSVPFPQLLRAAARRNEADIAHLNRTVDELVRDRRTSGADGGGDLLDRMLETSHPQTGERLSAENVRRQVITFLVAGHETTSGALSFALHYLARHPEIAARARAEVDQVWGDTAEPGYDQVAKLRHVRRVLDETLRLWPTAPAFAREAREDTVLAGVHPMRRGAWTLILLPMVHRDPAVWGADAERFDPDRFEAKAVRSRPAHTYKPFGTGARACIGRQFALHEATLVLGLLLRRYELRPDPAYRLRVTERLTLMPERLRLRLERRSAPVTVPSPAAAEAPASEPRCPVHGAGD
>NZ_CP022744.1|WP_067443411.1|9179061_9179568_-|FBP-domain-containing-protein
MRSLTEQDIRTSFINCSKGEAKRLAVPRDLAERPWDDLDFLGWRDPGAPDRSYLVAERDGKLLGVTMRFPSSQRGFLHRSMCSLCLTTHRGGGVSLMTARKAGTAGREGNSVGLYMCTDLACSLYLRGRKIPDSGSRFEESLTLEEQISRTTDNLNAFLGKLRDPVRN
>NZ_CP022744.1|WP_067443412.1|9179618_9180623_+|DUF3626-domain-containing-protein
MARVGRRSEGEPVDFRDVGSVRARLALRHVAGVSSGPALAGDLRITLNFHPDRLVRGLSVLDALAQDGAYHSQFVTGTSNGGLTAHPGGDRWRWESRIFGGAYDDADPHERPVYGALNFRGQVVGAAPRFGSSHFRLTGAASARATFCYPDSAAEPVDFGVAAGMSLIALAEGDEQDALNDYIEAQVHAGVVLARDVEALVLDACYRGTSVEAAARRLPCPVEWHPGYRLTVAELYRHADYRGPEYADLGARIAEDGRIDPRIIGDAARTGRHELQDLKMVWHTLARFGAPEGAGTALRQSAVYSSVVEAGVTEAGVAEAGVGGHTPEVSTPSA
>NZ_CP022744.1|WP_182449333.1|9180526_9181177_-|PAS-domain-containing-protein
MWRNRAFLIFDRVSVPVAVCDVYGAVLLANPAMAAECGTAPGRLRGREVLDLFRPREAGQVERIAQALRLRHRSRYQVSVTWEGPGGTRKYGELTADPVSDTVEETPALLVMLRVLGEREPHAREAAPVRVAPVEARILALLAGGATTARAARETGLTTDGVTYHLRRLSARWGAANRTELVARAYALGVLTSGVWPPTPASATPASVTPASTTEE
>NZ_CP022744.1|WP_067443414.1|9181345_9184513_+|cytochrome-P450
MPPTAQTTPDLPDVPVVDISDTGPGCTPLQQVMGLMREHGPLLVRRLHGRDVTFVADLDLVTELADETRFAKAVGPALENVREFAADGLFTAYSEEPNWARAHDILMPAFALGSMRTYHPVMLEVARRLIGSWDRAAFAGRPVNVPDDMTRMTLDTIGLAGFGYDFGSFDRDEPHPFVESMVRCLEWAMTRLARTPGSDHTAADEAFRTDAAHLAQVVDDVINARLASGESGGDDLLGLMLTATHPADGTTLDTTNIRNQVITFLIAGHETTSGAMSFAMYYLAKHPAVLQLVRREVDELWGDTADPEPTFDEVGRLTYTRQVLNEALRLWPTAAAFSRQAREDTLLGGRIPLRAGQALTVVAPMLHRQPVWGDNPELFDPSRFTPEAEAARSPHAFKPFGTGERACIGRQFALHEATMLLALLVHRYRLHDHADYRLTVKEALTLKPDGFTLTLTPRTGADRAHPPLPGAAPLTEAAAVSDAALPARVRRGTRALFLHGSNYGTCRDFAARLADEAAAVGCETEVAPLDAYAGGLPTDRTVVITAASYNGQPTDDARQFATWLDEATDAGGVHYAVLGVGDRNWAATYQHVPTRIDERLAELGATRLLDRAAGDASGDLTGTVRAFTADLRTALLTAHGDPDAVAPAPEPETAYEVRTLTSGPLDALAERHDLVPMTVTEAYGLTAPGHPRLKRFVRLALPAGTTYRTADHVTVLPVNDKALVERAAAALGVDLDSVLDIRATRPRSDGLAVDRPLTVRQLLAHHVELLRRPSAGQRSALATANPCPPERAQLAALGDDDPRTLVELFEAYPALRGALDWPALLDLLTPLRPRHYSVSSSPATDPGHVDLMVSLLEAPARSGNGTYRGVGSGHLAGVQPGDTVLARVQPCRDAFRVDHSRPVVMIAAGTGLAPFRGAVADRVAALARGEQLPPALCYFGCDAPEADFLHAEELRAAQTAGAVRLRPAFSAVPEGEVRFVQHRVAAEADEVAELLDAGARVYVCGDGSRMAPGVREAFRTLYRERTPGADEAAAERWLDGLVRDGRYVEDVYAAG
>NZ_CP022744.1|WP_067443415.1|9184587_9185586_+|aminoglycoside-phosphotransferase-family-protein
MDSWERARLVLDGAHLSADRLAHLRPLTGGTYNTVEELLLTDGSRYVLKVAPDPSVPGMRHEKRLLVAEAEFYRAAAEAGVPAPRTLALGEEPAVAHLLMTACPGEPWDGSVTDAERAPLRTELGRQTARLHRITGPGFGYPSGALGPLAPDWRTAFGIMVEAVLDDVRDYRARLPRPVETVARTLRAGFPALDEVITPRLVHFDLWDGNILLDRPAGEEPRIGGLIDGERMFWGDPLADFVSLALLADIEQDTAFLAGYRDAGGRTDFDASARLRLALYRAYLYLIMLTEGVPRAFEADRWRWLEEAVAPELVAALDEIEDLAPRLGPVGP
>NZ_CP022744.1|WP_067443416.1|9185667_9186957_+|ROK-family-protein
MAGRNGRTVRDLRRANRTAVLQRLYFDGPLSRFELGPVTGLSSGSISNVVADLVADGLLEEAGSVESDGGRPRTLLRVAPGSGHMIGVDVGETRVRIELFDLTLTELARTERPLTDREYEVEVIVGHIRDGIAEVLAEVGLAPERLLGVGIGVPGIVEYTPERGAVVHGQTIGWDAVPLEELLRAGSPLPDDVRYFIDNGAQTLGQAEMWFGGGRGARNAVVVLFGSGVGACLVTPEVDHGRAVEWGHLTVRVRGRRCRCGALGCLEAYAGAESLLRRWHEEGGRPPQGVDEETALTAMMAAAYPGESGTADPVALAVLEETAEYLGAGLSDLINLFQPERILIGGWAGLQLGARFLPAVRRHAMSYALRHPAQKVSVDLGRLGPDAVTVGAAILPLADFFGRGGRRLEPAPEGPAPAWRTALEERAPH
>NZ_CP022744.1|WP_067443417.1|9187035_9187350_+|hypothetical-protein
MAAHRSEGPGENGAPIPRDLPDQQAHDGEDPWEVGDGRAQGDTVDSTEAADTTAAERAGDSEPEGTEDADADVPDTDESGTGRRGAPRSGAVHEEHPVPDEPSA
>NZ_CP022744.1|WP_067443418.1|9187374_9188403_-|SDR-family-oxidoreductase
MSTSAGSRIVVTGATGNVGTSLVRLLSEDPEVESVRGLARRIPDWSPRKTEWSAVDLASEQADLVKEFEGAAAVVHLAWAFQPTHDPATTWRTNVLGSMRVFDAVAAAGVPTLVHASSVGAYSPGPKGHAVDESWPTHGWPDAAYCREKAYLERALDTFERDRPGVRVVRMRPAFLFKRESASEQRRIFGGRFLPGPLARPELLPFLPDIPGLRVQALHTDDAADAYRLAVHSDVRGAFNLAGEPPVDAELLGEMLGARPVRLPRAAARSAIAAAWGLHLLPASPHLFDAVLRLPLMDCTRARAELRWRPEHTATEVLEEFLQGMQQGAGARTEPMRGRKVG
>NZ_CP022744.1|WP_067443419.1|9188470_9189139_+|M15-family-metallopeptidase
MSEIILMSDARVAAVAVEECGEPLVDVSGSLLVDDRKYKDSLGAETHLRRGVLERLLRAQSLLPDGLRLLFVEGYRPPALQRRYFERYADELRAAHPQWAADRIRTAASRYVSPPEIAPHTAGAAVDLTLADADGRELDLGTAMNASPEESGGACYTDAAGISEEARENRAVLGRALGAAGLVNYPTEWWHWSYGDRYWALATGAAVAPYGPKELEAQEAGA
>NZ_CP022744.1|WP_067443420.1|9189142_9189832_-|hypothetical-protein
MGDDFAVSEKRPNAAAQAITAVVLIGGIGAALWGLDPRETQAADEPATCSPASTAESRPSGNVSGDQLCTALNRPDLATLLGTPTEKAKTAGGSDSYFTSGDGTKTATPSGEVTFETYTVKLSATYDGLAVAEEGEYLGRTAEPRTVLGRPAVLYTTQTIALRFNLGGGDSESGPGVPARSLVIAQTARDRGGSFELTVFREDGMPPDDEALLRVAEQVLPTIPGWNKA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

104422 : 143468

Mollivirus(20.0%)

integrase,transposase,tail

attL 102227:102245|attR 132744:132762

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
102227:102245	attL	NA	NA	NA	NA
WP_107406530.1\|104422_105724_-\|transposase	IS256 family transposase	NA	NA	NA	NA
WP_152038956.1\|106165_106765_+	hypothetical protein	NA	NA	NA	NA
WP_152038957.1\|106950_107391_-	hypothetical protein	NA	NA	NA	NA
WP_067425216.1\|107796_108909_-	alkene reductase	NA	NA	NA	NA
WP_067425219.1\|109393_110740_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_067425222.1\|110913_111834_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_067425225.1\|112074_112683_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_067425228.1\|112771_113491_+	SDR family NAD(P)-dependent oxidoreductase	A0A0M4JSW6	Mollivirus	3.5e-05	44.4
WP_107406531.1\|114309_114780_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	Q716C2	Shigella_phage	2.7e-14	38.2
WP_159425312.1\|114776_115205_-	hypothetical protein	NA	NA	NA	NA
WP_067425231.1\|115440_116403_-	sugar phosphate isomerase/epimerase	NA	NA	NA	NA
WP_067425234.1\|116477_117497_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_067425237.1\|117593_118613_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_067425240.1\|118733_119516_-	TIM barrel protein	NA	NA	NA	NA
WP_067425243.1\|119697_120732_+	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_159425313.1\|122214_122478_+	hypothetical protein	NA	NA	NA	NA
WP_067425249.1\|122684_124112_+	hypothetical protein	NA	NA	NA	NA
WP_067425252.1\|124586_125150_+	YcxB family protein	NA	NA	NA	NA
WP_067425400.1\|125247_125805_-	terminal protein TpgA2	NA	NA	NA	NA
WP_182449130.1\|126377_126521_-	hypothetical protein	NA	NA	NA	NA
WP_182449131.1\|126528_126837_+	hypothetical protein	NA	NA	NA	NA
WP_152038959.1\|127296_127707_+	hypothetical protein	NA	NA	NA	NA
WP_067425264.1\|128178_128634_-	VOC family protein	NA	NA	NA	NA
WP_152038960.1\|128748_129198_+\|tail	tail fiber domain-containing protein	NA	NA	NA	NA
WP_159425314.1\|129446_129611_+	hypothetical protein	NA	NA	NA	NA
WP_067425271.1\|129773_130880_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_192902652.1\|130987_131122_-	class III lanthipeptide	NA	NA	NA	NA
WP_067425274.1\|131118_133806_-	class III lanthionine synthetase LanKC	NA	NA	NA	NA
132744:132762	attR	NA	NA	NA	NA
WP_079164337.1\|135467_136496_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_067425277.1\|136578_137415_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_067425280.1\|137616_138825_-\|transposase	transposase	A0A0R8V9X2	Thermobifida_phage	5.8e-154	76.2
WP_067425283.1\|138986_139415_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_067425286.1\|140503_140761_+	hypothetical protein	NA	NA	NA	NA
WP_067444703.1\|140908_141541_-	hypothetical protein	NA	NA	NA	NA
WP_067425289.1\|141773_142988_-\|transposase	transposase	A0A068A1P5	Thermus_phage	4.2e-59	37.3
WP_079164338.1\|143039_143468_+\|transposase	IS200/IS605 family transposase	I4AZM1	Saccharomonospora_phage	1.7e-44	64.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022744

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection