CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022898	Staphylococcus aureus strain 422 chromosome, complete genome	10 crisprs	cas3,DEDDh,DinG,csa3,WYL	3	4	10	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022898_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_1

481005-481094

Unclear

Consensus_repeat	Method
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP022898_1

>merge|NZ_CP022898|1|481005-481094|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTGACGAAAAGTCAGCTTACGATAAAGTGCAAGTTGGGGTGTGGGCCCCAACATAGAAGCTG

>NZ_CP022898|1|1|481005-481094|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	ACGAAAAGTCAGCTTACGATAAAGTGCA
AGTTGGGGTGTGGGCCCCAACATAGAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_000551283.1\|477891_478431_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP022898.1\|WP_001154302.1\|484416_484782_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|238298
NZ_CP022898.1\|WP_000792417.1\|475513_475906_+\|septum-formation-initiator-family-protein	unknown	unknown	gnl\|CDD\|225471
NZ_CP022898.1\|WP_000613714.1\|484778_485255_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|223872
NZ_CP022898.1\|WP_000148607.1\|481427_482309_+\|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl\|CDD\|234643
NZ_CP022898.1\|WP_000951460.1\|474042_475236_+\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|226465
NZ_CP022898.1\|WP_047213181.1\|472516_474043_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
NZ_CP022898.1\|WP_001167888.1\|478688_480782_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	unknown	unknown	gnl\|CDD\|273520
NZ_CP022898.1\|WP_000690439.1\|502207_502768_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	unknown	unknown	gnl\|CDD\|237411
NZ_CP022898.1\|WP_001234988.1\|475232_475496_+\|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl\|CDD\|224109
NZ_CP022898.1\|WP_000649791.1\|468448_469021_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|223271
NZ_CP022898.1\|WP_001790128.1\|485648_485741_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_115385506.1\|476591_477887_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|366502
NZ_CP022898.1\|WP_000034728.1\|501316_502204_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	unknown	unknown	gnl\|CDD\|179769
NZ_CP022898.1\|WP_047213184.1\|482487_483420_+\|cysteine-synthase-A	unknown	unknown	gnl\|CDD\|273465
NZ_CP022898.1\|WP_047213187.1\|485793_487281_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP022898.1\|WP_115385505.1\|469020_472527_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_CP022898.1\|WP_000021445.1\|476010_476412_+\|RNA-binding-protein-S1	unknown	unknown	gnl\|CDD\|236305
NZ_CP022898.1\|WP_000799253.1\|499830_501213_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP022898.1\|WP_000167928.1\|483635_484439_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_000551283.1\|477891_478431_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	4.50006e-94
NZ_CP022898.1\|WP_001154302.1\|484416_484782_+\|dihydroneopterin-aldolase	gnl\|CDD\|238298	cd00534, DHNA_DHNTPE, Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is DHNA which catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. Though it is known that DHNTPE catalyzes the epimerization of dihydroneopterin triphosphate to dihydromonapterin triphosphate, the biological role of this enzyme is still unclear. It is hypothesized that it is not an essential protein since a folX knockout in E. coli has a normal phenotype and the fact that folX is not present in H. influenza. In addition both enzymes have been shown to be able to compensate for the other's activity albeit at slower reaction rates. The functional enzyme for both is an octamer of identical subunits. Mammals lack many of the enzymes in the folate pathway including, DHNA and DHNTPE.	1.74147e-48
NZ_CP022898.1\|WP_000792417.1\|475513_475906_+\|septum-formation-initiator-family-protein	gnl\|CDD\|225471	COG2919, COG2919, Septum formation initiator [Cell division and chromosome partitioning].	3.2193e-21
NZ_CP022898.1\|WP_000613714.1\|484778_485255_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	9.12434e-73
NZ_CP022898.1\|WP_000148607.1\|481427_482309_+\|Hsp33-family-molecular-chaperone-HslO	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	1.29884e-159
NZ_CP022898.1\|WP_000951460.1\|474042_475236_+\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|226465	COG3956, COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only].	0
NZ_CP022898.1\|WP_047213181.1\|472516_474043_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.05199e-87
NZ_CP022898.1\|WP_001167888.1\|478688_480782_+\|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP022898.1\|WP_000690439.1\|502207_502768_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	gnl\|CDD\|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	9.71225e-112
NZ_CP022898.1\|WP_001234988.1\|475232_475496_+\|RNA-binding-S4-domain-containing-protein	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	2.63429e-32
NZ_CP022898.1\|WP_000649791.1\|468448_469021_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|223271	COG0193, Pth, Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis].	5.81135e-97
NZ_CP022898.1\|WP_115385506.1\|476591_477887_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|366502	pfam01171, ATP_bind_3, PP-loop family. This family of proteins belongs to the PP-loop superfamily.	3.71037e-77
NZ_CP022898.1\|WP_000034728.1\|501316_502204_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	gnl\|CDD\|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	0
NZ_CP022898.1\|WP_047213184.1\|482487_483420_+\|cysteine-synthase-A	gnl\|CDD\|273465	TIGR01139, Cysteine_synthase, cysteine synthase A. This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family].	3.8342e-167
NZ_CP022898.1\|WP_047213187.1\|485793_487281_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP022898.1\|WP_115385505.1\|469020_472527_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_CP022898.1\|WP_000021445.1\|476010_476412_+\|RNA-binding-protein-S1	gnl\|CDD\|236305	PRK08582, PRK08582, RNA-binding protein S1.	4.42227e-78
NZ_CP022898.1\|WP_000799253.1\|499830_501213_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.73424e-131
NZ_CP022898.1\|WP_000167928.1\|483635_484439_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.16187e-122

>NZ_CP022898.1|WP_001167888.1|478688_480782_+|ATP-dependent-metallopeptidase-FtsH/Yme1/Tma-family-protein
MQKAFRNVLVIVIIGVIIFGLFSYLNGNGNMPKQLTYNQFTEKLEKGDLKTLEIQPQQNVYMVSGKTKNDEDYSSTILYNNEKELQKITDAAKKQNGVKLTIKEEEKQSVFVSILSTLIPVVVIALLFIFFLSQAQGGGSGGRMMNFGKSKAKMYDNNKRRVRFSDVAGADEEKQELIEIVDFLKDNKKFKEMGSRIPKGVLLVGPPGTGKTLLARAVAGEAGAPFFSISGSDFVEMFVGVGASRVRDLFDNAKKNAPCIIFIDEIDAVGRQRGAGVGGGHDEREQTLNQLLVEMDGFGENEGIIMIAATNRPDILDPALLRPGRFDRQIQVGRPDVKGREAILHVHAKNKPLDETVDLKAISQRTPGFSGADLENLLNEASLIAVREGKKKIDMRDIEEATDRVIAGPAKKSRVISKKERNIVAHHEAGHTIIGMVLDEAEVVHKVTIVPRGQAGGYAMMLPKQDRFLMTEQELLDKICGLLGGRVSEDINFNEVSTGASNDFERATQIARSMVTQYGMSKKLGPLQFGHSNGQVFLGKDMQGEPNYSSQIAYEIDKEVQRIVKEQYERCKQILLEHKEQLILIAETLLTEETLVAEQIQSLFYEGKLPEIDYDAAKVVKDEDSEFNDGKFGKSYEEIRKEQLEDGQRDESEDRKEEKDIAEDKKEADKSDEKDEPAHRQAPNIEKPYDPNHPDNK
>NZ_CP022898.1|WP_000551283.1|477891_478431_+|hypoxanthine-phosphoribosyltransferase
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
>NZ_CP022898.1|WP_115385506.1|476591_477887_+|tRNA-lysidine(34)-synthetase-TilS
MQLNSNGWHVDDHIVVSVSTGIDSMCLLYQLLKDYKDSYRKLTCLHVNHGVRSASIEEARFLEAYCERHHIDLHIKKLDLSHSLNRNNSIQNEARIKRYEWFDEMMNVLEADVLLTAHHLDDQLETIMYRIFNGKSTRNKLGFDELSKRKGYQIYRPLLAVSKKEIKQFQERYHIPYFEDESNKDNKYVRNDIRNRIIPAIDENNQLKVSHLLKLKQWHDEQYDILQYSAKQFIQEFVKFDEQSKYLEVSRQSFNDLPNSLKMVVLDCLLSKYYELFNISAKTYEEWFKQFSSKKAQFSINLTDKWIIQIAYGKLIIMAKNNGDTYFRVQTIEKPGNYIFNKYRLEIHSNLPKCLFPLSVRTRQSGDTFKLNGRDGYKKVNRLFIDCKVQQWVRDQMPIVLDKQQRIIAVGDLYQQQTIKQWIIISKNGDE
>NZ_CP022898.1|WP_000021445.1|476010_476412_+|RNA-binding-protein-S1
MSIEVGNKLKGKVTGIKKFGAFVELPEGKSGLVHISEVADNYVENVEEHLSVGDEVDVKVLSIADDGKISLSIKKAKDRPRRQHTSKPSHQKPVQKAEDFEKKLSNFLKDSEDKLTSIKRQTESRRGGKGSRR
>NZ_CP022898.1|WP_000792417.1|475513_475906_+|septum-formation-initiator-family-protein
MKNKVEHIENQYTSQENKKKQRQKMKMRVVRRRITVFAGVLLAIIVVLSILLVVQKHRNDIDAQERKAKEAQFQKQQNEEIALKEKLNNLNDKDYIEKIARDDYYLSNKGEVIFRLPEDKDSSSSKSSKK
>NZ_CP022898.1|WP_001234988.1|475232_475496_+|RNA-binding-S4-domain-containing-protein
MRLDKYLKVSRLIKRRTLAKEVSDQGRITINGNVAKAGSDVKVEDVLTIRFGQKLVTVKVTALNEHASKDNAKGMYEIIEERRLEEA
>NZ_CP022898.1|WP_000951460.1|474042_475236_+|nucleotide-pyrophosphohydrolase
MAHTITIVGLGNYGIDDLPLGIYKFLKTQNKVYARTLDHPVIESLQDELTFQSFDHVYETHDQFEDVYNDIVAQLVEAANEKDIVYAVPGHPRVAETTTVKLLALAKDNTDIDVKVLGGKSFIDDVFEAVNVDPNDGFTLLDATSLQEVTLNVRTHTLITQVYSAMVAANLKITLMERYPDDYPVQIVTGARSDGADNVVTCPLYELDHDENAFNNLTSVFVPKITTPTYLYHDFDFATEVIDTLVDEDKGCPWDKVQTHETLKRYLLEETFELFEAIDNEDDWHMIEELGDILLQVLLHTSIGKKEGYIDIKEVITSLNAKMIRRHPHIFGDANAETIDDLKEIWSKAKDAEGKQPRVKFEKVFAEHFLNLYEKTKDKSFDEAALKQWLEKGESNT
>NZ_CP022898.1|WP_047213181.1|472516_474043_+|polysaccharide-biosynthesis-protein
MKHKEAFNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGEYHSDEAYAKAVAYIQLVGILLFIAIFVFANNIAYMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVTIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLVAHRPFKFKMVNNTAKIVWKQFALSVLIFAISQLIVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYDRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMMAGLVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHLHAMRRFFINVVLGMVFMSIVVQCVLNIVTTHGRITGLIELLCAAVLGIIALFFYIFRFNVLTYKELTYLPFGSKLYQIKKGRR
>NZ_CP022898.1|WP_115385505.1|469020_472527_+|transcription-repair-coupling-factor
MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFVDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRGFDVETQRSKDNIEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIDYFQKDAIIAVDEFNRIKETEESLTVESDTFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA
>NZ_CP022898.1|WP_000649791.1|468448_469021_+|aminoacyl-tRNA-hydrolase
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
>NZ_CP022898.1|WP_000148607.1|481427_482309_+|Hsp33-family-molecular-chaperone-HslO
MTHDYIVKALAFDGEIRAYAALTTETVQEAQTRHYTWPTASAAMGRTMTATAMMGAMLKGDQKLTVTVDGQGPIGRIIADANAKGEVRAYVDHPQTHFPLNEQGKLDVRRAVGTNGSIMVVKDVGMKDYFSGASPIVSGELGEDFTYYYATSEQTPSSVGLGVLVNPDNTIKAAGGFIIQVMPGAKDETISKLEKAISEMTPVSKLIEQGLTPEGLLNEILGKDHVQILEKMPVQFECNCSHEKFLNAIKGLGEAEIQNMIKEDHGAEAVCHFCGNKYKYTEEELNVLLESLV
>NZ_CP022898.1|WP_047213184.1|482487_483420_+|cysteine-synthase-A
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLDYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEVVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYDSIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD
>NZ_CP022898.1|WP_000167928.1|483635_484439_+|dihydropteroate-synthase
MTKTKIMGILNVTPDSFSDGGKFNNVESAVTRVKAMMDEGADIIDVGGASTRPGHEMISLEEELNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDIINDQWAGLYDHRMFQVVAKYDAEIVLMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGISSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNLS
>NZ_CP022898.1|WP_001154302.1|484416_484782_+|dihydroneopterin-aldolase
MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLAEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK
>NZ_CP022898.1|WP_000613714.1|484778_485255_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MIQAYLGLGSNIGDRESQLNDAIKILNEYDGINVFNISPIYETAPVGYTEQPNFLNLCVEIQTTLTVLQLLECCLKTEECLHRVRKERWGPRTLDVDILLYGEEMIDLPKLSVPHPRMNERAFVLIPLNDIAANVIEPRSKLKVKDLVFVDDSVKRYK
>NZ_CP022898.1|WP_001790128.1|485648_485741_+|hypothetical-protein
MVNDKVLETSKEMYVEQKCLIFYKTLKENV
>NZ_CP022898.1|WP_047213187.1|485793_487281_+|lysine--tRNA-ligase
MSEEMNDQMLVRRQKLQELYDLGIDPFGSKFDRSGLSSDLKEEWDQYSKEELVEKEADSHVAIAGRLMTKRGKGKAGFAHVQDLAGQIQIYVRKDQVGDDEFDLWKNADLGDIVGVEGVMFKTNTGELSVKAKKFTLLTKSLRPLPDKFHGLQDIEQRYRQRYLDLITNEDSTRTFINRSKIIQEMRNYLNNKGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTESMVRHIANEVLGSAKVQYNGETIDLESAWTRLHIVDAVKEATGVDFYEIKSDEEAKALAKEHGIEIKDTMKYGHILNEFFEQKVEETLIQPTFIYGHPTEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQKGRFEAQLVEKAQGNDEAHEMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVLLFPYMRQK
>NZ_CP022898.1|WP_000799253.1|499830_501213_-|PLP-dependent-aminotransferase-family-protein
MKNTLYHQLYEKLKKQIIEGQFKEGDKFYSKRQLSKHLSISQTTVEHAYQLLLDEGYIYSRPRSGYFVSEIESLTILNNQPIPSLFDDDSYKPKASDEAYDYAFNLDEIDTKHFPIELFRKYSKDLYDTNHLNQLRRGHFQGELHLRFQLAFYLFTNRGVICDPNQIIIGSSTEQLVNQLVDLLYTSTFIIEKPSYPPIKNILDKKQVEYEQIEVEDNGINVDEVIKSQKNIVYITPSHQFPTGYVMDLKKRTQLIQWAQEKEERFIIEDDYDSEFRYFGKPIPAIQGLYSRGEKVIYISTFSKSIFPSCRVAYMVLPYSIMKKYHSQNHIEGNTVPVHMQNLIATFISSGGFERHLNKMRRIYRRKLTYILNRLKPYKEQLDIQGAETGMHFTITVKNGLTLQECLDRANKVKLKLQVYNFDDDQDYKKTPKFILGFGGIDDDALKPHVDALIKSLIIK
>NZ_CP022898.1|WP_000034728.1|501316_502204_+|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS
MSKIIGSDRVKRGMAEMQKGGVIMDVVNAEQARIAEEAGAVAVMALERVPSDIRAAGGVARMANPKIVEEVMNAVSIPVMAKARIGHITEARVLEAMGVDYIDESEVLTPADEEYHLRKDQFTVPFVCGCRNLGEAARRIGEGAAMLRTKGEPGTGNIVEAVRHMRQVNSEVSRLTVMNDDEIMTFAKDIGAPYEILKQIKDNGRLPVVNFAAGGVATPQDAALMMELGADGVFVGSGIFKSEDPEKFAKAIVQATTHYQDYELIGRLASELGTAMKGLDINQLSLEERMQERGW
>NZ_CP022898.1|WP_000690439.1|502207_502768_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT
MKIGVLALQGAVREHIRHIELSGHEGIAVKKVEQLEEIEGLILPGGESTTLRRLMNLYGFKEALQNSTLPMFGTCAGLIVLAQDIVGEEGYLNKLNITVQRNSFGRQVDSFETELDIKGIATDIEGVFIRAPHIEKVGQGVDILCKVNEKIVAVQQGKYLGVSFHPELTDDYRVTDYFINHIVKKA

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Crispr_ID: NZ_CP022898_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_2

1041937-1042033

Orphan

Consensus_repeat	Method
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_2

>merge|NZ_CP022898|2|1041937-1042033|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGGTAAAAGAGGGATACTTGCGCTGAGCGCATGCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

>NZ_CP022898|2|2|1041937-1042033|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	TAAAAGAGGGATACTTGCGCTGAGCGCAT
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_000381852.1\|1050321_1051683_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP022898.1\|WP_115385535.1\|1034043_1035072_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NZ_CP022898.1\|WP_031927757.1\|1046272_1047991_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP022898.1\|WP_031927754.1\|1037155_1038403_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|237507
NZ_CP022898.1\|WP_000921977.1\|1039467_1040868_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP022898.1\|WP_000709282.1\|1035655_1037134_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_CP022898.1\|WP_115385536.1\|1044048_1045254_+\|class-I-SAM-dependent-rRNA-methyltransferase	unknown	unknown	gnl\|CDD\|224017
NZ_CP022898.1\|WP_031927753.1\|1035074_1035641_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|223376
NZ_CP022898.1\|WP_115385534.1\|1030397_1032587_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	unknown	unknown	gnl\|CDD\|234921
NZ_CP022898.1\|WP_000033477.1\|1040883_1041459_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227065
NZ_CP022898.1\|WP_000666799.1\|1029733_1030405_+\|phosphoribosylformylglycinamidine-synthase-I	unknown	unknown	gnl\|CDD\|235140
NZ_CP022898.1\|WP_103225775.1\|1048073_1049641_+\|IS3-like-element-ISSau2-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP022898.1\|WP_000638453.1\|1051679_1052699_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
NZ_CP022898.1\|WP_000437472.1\|1046003_1046270_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
NZ_CP022898.1\|WP_000064214.1\|1042042_1042177_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_001289618.1\|1049890_1050124_-\|glutaredoxin-family-protein	unknown	unknown	gnl\|CDD\|239274
NZ_CP022898.1\|WP_000273259.1\|1038668_1039475_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP022898.1\|WP_000848351.1\|1029468_1029732_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl\|CDD\|224741
NZ_CP022898.1\|WP_000505962.1\|1045307_1045850_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368297
NZ_CP022898.1\|WP_000009069.1\|1042328_1043624_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_115385535.1\|1034043_1035072_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
NZ_CP022898.1\|WP_031927757.1\|1046272_1047991_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_CP022898.1\|WP_031927754.1\|1037155_1038403_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|237507	PRK13790, PRK13790, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP022898.1\|WP_000921977.1\|1039467_1040868_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	9.64258e-65
NZ_CP022898.1\|WP_000709282.1\|1035655_1037134_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_CP022898.1\|WP_115385536.1\|1044048_1045254_+\|class-I-SAM-dependent-rRNA-methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	5.99133e-145
NZ_CP022898.1\|WP_031927753.1\|1035074_1035641_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|223376	COG0299, PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism].	1.64347e-91
NZ_CP022898.1\|WP_115385534.1\|1030397_1032587_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurL	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
NZ_CP022898.1\|WP_000033477.1\|1040883_1041459_-\|ECF-transporter-S-component	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	4.34592e-70
NZ_CP022898.1\|WP_000666799.1\|1029733_1030405_+\|phosphoribosylformylglycinamidine-synthase-I	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	1.77638e-140
NZ_CP022898.1\|WP_103225775.1\|1048073_1049641_+\|IS3-like-element-ISSau2-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	6.32114e-44
NZ_CP022898.1\|WP_000638453.1\|1051679_1052699_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	1.67944e-76
NZ_CP022898.1\|WP_000437472.1\|1046003_1046270_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	2.44795e-51
NZ_CP022898.1\|WP_001289618.1\|1049890_1050124_-\|glutaredoxin-family-protein	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	1.21197e-16
NZ_CP022898.1\|WP_000273259.1\|1038668_1039475_-\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.09792e-29
NZ_CP022898.1\|WP_000848351.1\|1029468_1029732_+\|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl\|CDD\|224741	COG1828, PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism].	2.06309e-30
NZ_CP022898.1\|WP_000505962.1\|1045307_1045850_+\|hypothetical-protein	gnl\|CDD\|368297	pfam05128, DUF697, Domain of unknown function (DUF697). Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	0.00760449
NZ_CP022898.1\|WP_000381852.1\|1050321_1051683_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	1.81103e-165

>NZ_CP022898.1|WP_000033477.1|1040883_1041459_-|ECF-transporter-S-component
MSKGLKLSEILVTVLISVVFAVIYNLWWFVYNGVQATGLHLEQLTNGVWFMAAIVCYLIIPKPGIALLAEFAAGAGETIIMGRFDIPTIVYAFIQGLACELVFAIFKYQSRSVMVAMLAGFCTAIAAFPIDYFYGYLNEVAGWNLTLFIVFRLISGAVVAGVLSYLLVKALDKTGVTKLFRPAAKEDYDNL
>NZ_CP022898.1|WP_000921977.1|1039467_1040868_-|ABC-transporter-ATP-binding-protein
MLKVSDLRLKYPSGQRKIFDHLNITIQDKEKVLLLGPSGCGKSTLLNVLSGIVPNLIELPMKYDELIVDPLSGVIFQDPDSQFCMPKVYEELAFVLENRQVPREDMDALIINALNMVNLNVTPETYIKDLSGGMKQKLAIVETILQQSKTLFLDEPTAMLDVQATEDLWTKLIELWENQTVVIVEHKVKHIWNHVDRVILMDYNGNIIADECPEIILQKYVHLLSEYGVWHPRAWEFAPSRVDFPTANSHLLQFKNGRIIRGKSTLLSFSDLEIGLGEWITITGANGSGKTTLLESIMQLIKYQGDVYFENQRLTKIKHAAKHMYLVYQNPELQFITNSVYDEINIHFNHLSKDQSDDETMQLLKLLDLENVKDQHPYELSIGQKRRLSVATALSSKADIIFLDEPTFGLDSHNTFQLIKLFQKRINLGQSIVMVTHDDEIIERYPSRRLKISDGALLDCDGDTNV
>NZ_CP022898.1|WP_000273259.1|1038668_1039475_-|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MYEQWKVRQSFVDDVNIITKLFLGIILFFFIIFVHNFDFMLYITILMLVFLLMFNGTQFKITAIFITISIGFALLSSLFMILYGNGSHTILKFGFIHITTESLVRGLHVSLRTIAISFFGILIALTSQVVMIFYSLMQHLKVKSKVAYAFMAAIRMIPLMISSLIQLRRSLKMRYQMIDASNYRGLKRFKHLIIPLLSQNIRKAHQLSVAMESKGFRDGPRTYYYNVPFSYKDVIFIIVLIAIITLAYYCSINLPITGIDDVRLGRVG
>NZ_CP022898.1|WP_031927754.1|1037155_1038403_+|phosphoribosylamine--glycine-ligase
MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISESDHQGILDFAKQQDVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVHDAQRDAYEKVSQIQSDHLFYRHDIANKALQLK
>NZ_CP022898.1|WP_000709282.1|1035655_1037134_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MKKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRAAAKNYKHVTTIVHPADYQEVLTRLRNDSLDESYRQSLMIKVFEHTAEYDEAIVRFFKGDKETLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIKDADATLALVKKFDTPAAVAVKHMNPCGVGIGDTIEQAFQHAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKKNVRLLEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMKVVTEVAPTDEQWEAMLLGWKVVPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIALERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVVTGTRHFKH
>NZ_CP022898.1|WP_031927753.1|1035074_1035641_+|phosphoribosylglycinamide-formyltransferase
MVKIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQNAFCIDRAKKHDIPVYINEPKKFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKGIDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRQCDIRPDDSKEQLEEKVKKLEYELYPSVIAKIVK
>NZ_CP022898.1|WP_115385535.1|1034043_1035072_+|phosphoribosylformylglycinamidine-cyclo-ligase
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVEGGQVVIGLASSGIHSNGYSLVRKLINESGIELASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKAMNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQNVEAYQIGHIVKNESTAIELLGV
>NZ_CP022898.1|WP_115385534.1|1030397_1032587_+|phosphoribosylformylglycinamidine-synthase-subunit-PurL
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGEHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSFRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKNYNTSKNDYTHIDVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGVLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAIAQCLTTQD
>NZ_CP022898.1|WP_000666799.1|1029733_1030405_+|phosphoribosylformylglycinamidine-synthase-I
MKFAVLVFPGSNCDRDMFNAAIKSGVEAEYVDYRETSLSGFDGVLIPGGFSFGDYLRSGAMASVAPIISEVKRLAAEGKPVLGVCNGFQILTEIGLLPGALLHNDSHLFISRNEELEIVNNQTAFTNLYEQGEKVIYPVAHGEGHYYCTDEIYQQLKANNQIILKYVNNPNGSYDDIAGIVNEKGNVCGMMPHPERALETLLGTDSGVKLFEAMVKSWREQHV
>NZ_CP022898.1|WP_000848351.1|1029468_1029732_+|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MKTIELHITLQPQVLDTQGQTLTRAVHDLGYAQVNDIRVGKVLYMTVDEVSDEKVHNIITTLSEKLFANTVIEEYSYKVLEDEKENA
>NZ_CP022898.1|WP_000064214.1|1042042_1042177_-|hypothetical-protein
MSNENQNKKAAEKAKEVEEKLKDKKEEKTEDINQTKQDIQDTLN
>NZ_CP022898.1|WP_000009069.1|1042328_1043624_+|hypothetical-protein
MSFLRKHAEIIFSYLIGIVSLFTGLIILINLPLIKQLNGGKKVDTHVHNVWEFLNAFFSEIIKVMSRFIGNFPIVSAIVIIIFGILVMLIGHTLLRTIKYDYDISIFFLVIGIMYFIITLILMTQVYGFFAVIFIIPFTIHIGYIVYKDELNQENVKNHFMWIIVSYGISYLITQIALYGRIDANEIESIDILSVNAFFIIMWLLGQMAIWNFLFLRRALPLTKQELGEEEPELSRTSKGNVTNQTKIHLKQLQDKTTEYARKTRRSVDLDKIRAKRDKFKKKVNDIIDIQEDDIPDWMRKPKWVKPMYVELFCGVVIFLFTFLEFNNRNALFVSGDWKLSQTQYVIEWVTLLILLFIIIAYIATTLTFHLKGKFYYLQLFMGSILFFKLLTEFINIMIHGLLLSVFITPTLLLMLLAIIISYSLQLRERP
>NZ_CP022898.1|WP_115385536.1|1044048_1045254_+|class-I-SAM-dependent-rRNA-methyltransferase
MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGLGWVLTYDKAQEINTAFFVKLFKTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDGHLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEENFTFYNVDLEDGLMTGIFLDQKEVRKKLRNQYAKERHVLNLFSYTGAFSVIAASEASSTTSVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARNKKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELTEVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
>NZ_CP022898.1|WP_000505962.1|1045307_1045850_+|hypothetical-protein
MGFKNNLTSNLTNKIGNSVFKIENINEKGAMPTTIKELNERRQRAEAIVKRKSLMSSTMSVVPIPGLDFGVDLKLMKDIIEDVNKIYGLDHKQVNSLGDDVKERVMSAAAIQGSQFIGKRISSAFLKIVIRDVAKRTAAKQTKWFPVVGQAVSASISYYFMNKIGKDHIQKCENVIKNVM
>NZ_CP022898.1|WP_000437472.1|1046003_1046270_+|phosphocarrier-protein-HPr
MEQNSYVIIDETGIHARPATMLVQTASKFDSDIQLEYNGKKVNLKSIMGVMSLGVGKDAEITIYADGSDESDAIQAISDVLSKEGLTK
>NZ_CP022898.1|WP_031927757.1|1046272_1047991_+|phosphoenolpyruvate--protein-phosphotransferase
MSKLIKGIAASDGVAIAKAYLLVEPDLTFDKNEKVTDVEGEVAKFNGAIEASKVELTKIRNNAEVQLGADKAAIFDAHLLVLDDPELIQPIQDKIKNENANAATALTDVTTQFVTIFESMDNEYMKERAADIRDVSKRVLSHILGVELPNPSMIDESVVIVGNDLTPSDTAQLNKEFVQGFATNIGGRTSHSAIMSRSLEIPAIVGTKSITQEVKQGDMIIVDGLNGDVIVNPTEDELIAYQDKRERYFADKKELQKLRDADTVTVDGVHAELAANIGTPNDLPGVIENGAQGIGLYRTEFLYMGRDQMPTEEEQFEAYKEVLEAMNGKRVVVRTLDIGGDKELSYLNLPEEMNPFLGYRAIRLCLAQQDIFRPQLRALLRASVYGKLNIMFPMVATINEFREAKAILLEEKENLKNEGHDISDDIELGIMVEIPATAALADVFAKEVDFFSIGTNDLIQYTLAADRMSERVSYLYQPYNPSILRLVKQVIEASHKEGKWTGMCGEMAGDETAIPLLLGLGLDEFSMSATSILKARRQINGLSKNEMTELANRAVDCATQEEVIELVNNYVK
>NZ_CP022898.1|WP_103225775.1|1048073_1049641_+|IS3-like-element-ISSau2-family-transposase
MKTLKGALFMSIKPKVDIDVLLYMFQEYEKGVSFQYLIDTLQLDINVNTLYPKYKYYKTHGIETLLTQKQYNHYSKELKLKVVNEYLNSNQSTQDLAIKYNIRSSTQVKNWIKMYTVGKEIKNQSPKTGVYIMKARKTTFEERVTIVEYYLNHKQSYREVAEHFNISYGQIYQWVQKYQAHGKNGLVDGRGKGKPKSMMTPEEQKEAEIQALKAQNRLLEMENDVFKKVSSIGKRDDSKRKQITAYKTIEALKHQYPIQRLCRILGISRASYYKWVHYQSSELELENEQLKREIESIYHKYNGIYGYRRIYIYIRLKLGKQVNRKRIYRLMKELNLKAVIRQKRKPYRRSTPQITSENKLNRQFDIDTPNKVWLTDVTEFKIKEGSKIYLSAIYDLGVKRIVSYKLGPSNNNQLVFKTFNQAIEKVENTKGILFHSDRGFQYTSKTFKHMLDECGMIQSMSRVSKCIDNGPMEGVWGTIKSEIFRGNKHFKFNSVEEATKTIHDFILFFNHERITLKMADSV
>NZ_CP022898.1|WP_001289618.1|1049890_1050124_-|glutaredoxin-family-protein
MSEIIVYTQNDCPPCTFVKNYLNEHQIDFEERNINNQQYRNEMIDFDAFSTPFILLNGNPMYHVDLDEINKVLNIQD
>NZ_CP022898.1|WP_000381852.1|1050321_1051683_+|cytochrome-ubiquinol-oxidase-subunit-I
MDTVEISRFLTAMTLAVHIIFATIGVGMPLMFAIAEFLGIRKNDLQYIAMAKRWAKAYTITVAVGVVTGTIIGLQLSLIWPTFMEMGGHVIALPLFMETFAFFFEAIFLSIYLYTWDRFKNKWTHFLISIPVIIGGSFSAFFITSVNSFMNTPAGFELKNGKMVNVQPIEAMFNPSFIVRSFHVITTAGMTMAFVIASIAAFKLLRNRQPKDTVYHKKALKMSMIVGFFSTLLSMLAGDLSAKFLHKFQPEKLAAYEWHFDTSSHAKLLLFGVLDEKTQQVKGAIELPGLLSFLADNSVKTKVQGLNDFPKSLHPPMIVHYFFDLMVTMGILCFVISGVYVLTLMFKKLRKFSTHKWMLYGILLTGPASMLAIEFGWFLTEMGRQPWIVRGYMRVAEAATQAGGITFVTILFGVLYIILMYTCAYVLIRMFKNKPAYEDVNRLAKKQGGEIEK
>NZ_CP022898.1|WP_000638453.1|1051679_1052699_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MIYAFIGITVLWLFLFCYIIIASIDFGAGFFALHSKLTGDEKKINHLISRYLNPVWEVTNVFFVFFFVGFVGFFPESIKYLGTVLLIPGSIALIMISLRNSFYAFENYGQDTKLAWMIMYGVSGLLIPASLSTALTITEGGYINVRNNVIDLDWVQLLLSPFAWSVVFLAIISVLYISSGFLTYYAKKANDEPAYNLTRQWHIFLGPPMIIICLFVFLSLRIQNSEHFYSAVFDYWWMFAISFLFFALASLLTFFKKKHGLAFVFVILQMMFAFFGYGISKLPYLLYPFVKITDAYVNPEMGWTLVIVFILGLLLLLPSLILLLRLFVFDKEYVEGKKS

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Crispr_ID: NZ_CP022898_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_3

1768189-1768271

Orphan

Consensus_repeat	Method
TGCAAGTTGGGGTGGGGCCCCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_3

>merge|NZ_CP022898|3|1768189-1768271|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACACAGAAGGTGACGTAATGTCAACTTACTATAATGTGCAAGTTGGGGTAGGGCCCCAACA

>NZ_CP022898|3|3|1768189-1768271|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACA	CAGAAGGTGACGTAATGTCAACTTACTATAATG
TGCAAGTTGGGGTAGGGCCCCAACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_000634175.1\|1774111_1774612_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP022898.1\|WP_000717561.1\|1758838_1759807_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP022898.1\|WP_000818525.1\|1755348_1756710_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP022898.1\|WP_000123175.1\|1752562_1753831_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NZ_CP022898.1\|WP_000277602.1\|1769817_1770231_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP022898.1\|WP_000689995.1\|1772852_1773971_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP022898.1\|WP_000777192.1\|1770618_1771308_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_CP022898.1\|WP_000883646.1\|1760075_1761020_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_CP022898.1\|WP_000058379.1\|1762071_1763301_-\|NAD-dependent-malic-enzyme-4	unknown	unknown	gnl\|CDD\|235976
NZ_CP022898.1\|WP_000040069.1\|1774857_1776060_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP022898.1\|WP_000160435.1\|1768314_1769613_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NZ_CP022898.1\|WP_000226939.1\|1763752_1766950_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_CP022898.1\|WP_000626082.1\|1766970_1767912_-\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NZ_CP022898.1\|WP_001232650.1\|1757059_1758817_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NZ_CP022898.1\|WP_000840576.1\|1776147_1777095_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_CP022898.1\|WP_000829167.1\|1753879_1755001_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|184468
NZ_CP022898.1\|WP_000471571.1\|1761019_1761877_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_CP022898.1\|WP_000161654.1\|1771482_1772538_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_CP022898.1\|WP_000136257.1\|1777217_1777712_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NZ_CP022898.1\|WP_047213534.1\|1777809_1778580_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_000634175.1\|1774111_1774612_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
NZ_CP022898.1\|WP_000717561.1\|1758838_1759807_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NZ_CP022898.1\|WP_000818525.1\|1755348_1756710_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP022898.1\|WP_000123175.1\|1752562_1753831_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP022898.1\|WP_000277602.1\|1769817_1770231_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
NZ_CP022898.1\|WP_000689995.1\|1772852_1773971_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP022898.1\|WP_000777192.1\|1770618_1771308_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	2.522e-133
NZ_CP022898.1\|WP_000883646.1\|1760075_1761020_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_CP022898.1\|WP_000058379.1\|1762071_1763301_-\|NAD-dependent-malic-enzyme-4	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_CP022898.1\|WP_000040069.1\|1774857_1776060_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP022898.1\|WP_000160435.1\|1768314_1769613_-\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NZ_CP022898.1\|WP_000226939.1\|1763752_1766950_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_CP022898.1\|WP_000626082.1\|1766970_1767912_-\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	9.95606e-99
NZ_CP022898.1\|WP_001232650.1\|1757059_1758817_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NZ_CP022898.1\|WP_000840576.1\|1776147_1777095_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	3.79172e-57
NZ_CP022898.1\|WP_000829167.1\|1753879_1755001_-\|citrate-synthase	gnl\|CDD\|184468	PRK14035, PRK14035, citrate synthase; Provisional.	0
NZ_CP022898.1\|WP_000471571.1\|1761019_1761877_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_CP022898.1\|WP_000161654.1\|1771482_1772538_+\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	2.79772e-126
NZ_CP022898.1\|WP_000136257.1\|1777217_1777712_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	5.93419e-100
NZ_CP022898.1\|WP_047213534.1\|1777809_1778580_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	6.72678e-38

>NZ_CP022898.1|WP_000626082.1|1766970_1767912_-|pApA-hydrolase-Pde2
MISTLNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGSKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLEQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLATALRTKLN
>NZ_CP022898.1|WP_000226939.1|1763752_1766950_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVEALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTIETVVLAKDNNGLKDLYQLSSKIKMNSMENVSFELLQQFSSNLIIIFKNVADEHRDIVQVFDSHEDTYLDHQSVLVQGIKHVWIQNVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEIKQLDINQEYLTQVDVIAQKCNAELKYHQSLLPQYQTPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDNQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>NZ_CP022898.1|WP_000058379.1|1762071_1763301_-|NAD-dependent-malic-enzyme-4
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTIAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NZ_CP022898.1|WP_000471571.1|1761019_1761877_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NZ_CP022898.1|WP_000883646.1|1760075_1761020_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NZ_CP022898.1|WP_000717561.1|1758838_1759807_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NZ_CP022898.1|WP_001232650.1|1757059_1758817_-|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NZ_CP022898.1|WP_000818525.1|1755348_1756710_+|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK
>NZ_CP022898.1|WP_000829167.1|1753879_1755001_-|citrate-synthase
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDAYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>NZ_CP022898.1|WP_000123175.1|1752562_1753831_-|NADP-dependent-isocitrate-dehydrogenase
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK
>NZ_CP022898.1|WP_000160435.1|1768314_1769613_-|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVINFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANRTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NZ_CP022898.1|WP_000277602.1|1769817_1770231_+|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NZ_CP022898.1|WP_000777192.1|1770618_1771308_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKNTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NZ_CP022898.1|WP_000161654.1|1771482_1772538_+|aminopeptidase-P-family-protein
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDIDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPNKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGFEVLTHYEK
>NZ_CP022898.1|WP_000689995.1|1772852_1773971_-|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEDKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NZ_CP022898.1|WP_000634175.1|1774111_1774612_+|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>NZ_CP022898.1|WP_000040069.1|1774857_1776060_-|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVNGEKVKTVQDIKDHVEAVDIMLDAFKAHNIINDINDIDGTGHRVVHGGEKFPESVAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLLRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTFGGLK
>NZ_CP022898.1|WP_000840576.1|1776147_1777095_-|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSKEFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NZ_CP022898.1|WP_000136257.1|1777217_1777712_-|thiol-peroxidase
MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>NZ_CP022898.1|WP_047213534.1|1777809_1778580_-|TSUP-family-transporter
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSTIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLVFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLIMASSMIAGSYTGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFL

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Crispr_ID: NZ_CP022898_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_4

2083794-2083873

Orphan

Consensus_repeat	Method
GGCCCCACCCCAACTTACATTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_4

>merge|NZ_CP022898|4|2083794-2083873|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGTTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCACCCCAACTTGCATTGT

>NZ_CP022898|4|4|2083794-2083873|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGT	TTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGG
GGCCCCACCCCAACTTGCATTGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_031927406.1\|2082179_2083382_-\|5-aminolevulinate-synthase	unknown	unknown	gnl\|CDD\|236370
NZ_CP022898.1\|WP_000522380.1\|2091502_2092129_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
NZ_CP022898.1\|WP_001045081.1\|2084013_2085321_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
NZ_CP022898.1\|WP_001013104.1\|2073759_2073906_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_031918283.1\|2088930_2089215_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP022898.1\|WP_001208482.1\|2072571_2073342_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225484
NZ_CP022898.1\|WP_000201394.1\|2086515_2086695_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_047213641.1\|2085892_2086519_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000857174.1\|2074624_2075662_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP022898.1\|WP_000791409.1\|2078095_2079151_-\|bi-component-leukocidin-LukGH-subunit-H	unknown	unknown	gnl\|CDD\|369625
NZ_CP022898.1\|WP_000120321.1\|2090157_2091306_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275319
NZ_CP022898.1\|WP_047213639.1\|2077057_2078074_-\|bi-component-leukocidin-LukGH-subunit-G	unknown	unknown	gnl\|CDD\|369625
NZ_CP022898.1\|WP_000694770.1\|2073541_2073724_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000046023.1\|2093862_2093943_-\|delta-hemolysin	unknown	unknown	gnl\|CDD\|173213
NZ_CP022898.1\|WP_000191459.1\|2073902_2074517_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000206632.1\|2079586_2080810_+\|ArgE/DapE-family-deacylase	unknown	unknown	gnl\|CDD\|181490
NZ_CP022898.1\|WP_001108473.1\|2081307_2082177_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP022898.1\|WP_000197641.1\|2089389_2090133_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP022898.1\|WP_115385577.1\|2087238_2088855_-\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP022898.1\|WP_000867953.1\|2092480_2093266_+\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_031927406.1\|2082179_2083382_-\|5-aminolevulinate-synthase	gnl\|CDD\|236370	PRK09064, PRK09064, 5-aminolevulinate synthase; Validated.	0
NZ_CP022898.1\|WP_001045081.1\|2084013_2085321_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	9.80292e-81
NZ_CP022898.1\|WP_000857174.1\|2074624_2075662_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.6482e-25
NZ_CP022898.1\|WP_031918283.1\|2088930_2089215_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.20776e-44
NZ_CP022898.1\|WP_001208482.1\|2072571_2073342_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225484	COG2932, COG2932, Predicted transcriptional regulator [Transcription].	1.42295e-15
NZ_CP022898.1\|WP_000522380.1\|2091502_2092129_+\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	5.0673e-115
NZ_CP022898.1\|WP_000791409.1\|2078095_2079151_-\|bi-component-leukocidin-LukGH-subunit-H	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.31423e-77
NZ_CP022898.1\|WP_047213639.1\|2077057_2078074_-\|bi-component-leukocidin-LukGH-subunit-G	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.62134e-98
NZ_CP022898.1\|WP_000046023.1\|2093862_2093943_-\|delta-hemolysin	gnl\|CDD\|173213	PRK14752, PRK14752, delta-lysin family phenol-soluble modulin.	2.50854e-06
NZ_CP022898.1\|WP_000120321.1\|2090157_2091306_-\|hypothetical-protein	gnl\|CDD\|275319	TIGR04526, predic_Ig_block, putative immunoglobulin-blocking virulence protein. Members of this family are putative virulence proteins of Mycoplasma and Ureaplasma species. Members share a region of sequence similarity (see TIGR04524) with protein M, a Mycoplasma genitalium protein that binds a conserved light chain region of IgG and blocks its protective function of antigen-specific binding. The seed alignment for this model includes an N-terminal signal-anchor domain and a proline-rich linker domain, and a C-terminal extension, in addition to the protein M-like domain recognized by TIGR04524. [Cellular processes, Pathogenesis].	1.67862e-06
NZ_CP022898.1\|WP_000206632.1\|2079586_2080810_+\|ArgE/DapE-family-deacylase	gnl\|CDD\|181490	PRK08588, PRK08588, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_CP022898.1\|WP_001108473.1\|2081307_2082177_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.86916e-09
NZ_CP022898.1\|WP_000197641.1\|2089389_2090133_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.23687e-11
NZ_CP022898.1\|WP_115385577.1\|2087238_2088855_-\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP022898.1\|WP_000867953.1\|2092480_2093266_+\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	2.11308e-126

>NZ_CP022898.1|WP_031927406.1|2082179_2083382_-|5-aminolevulinate-synthase
MYKTLFFDKIAELKEKGSYRIFTEINRIANKYPLAKGEDGKEVVVFCSNDYLGMSQNQEVINVMSDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDAALQGLLRIFPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINIPKLIVFESVYSMDGDIAPIVEIVELAKEYNSLTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCLTSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLDKFNIYVQAINSPTVEIGTERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV
>NZ_CP022898.1|WP_001108473.1|2081307_2082177_-|DMT-family-transporter
MNYLMYLFCMFIWGLNFIAVKIQGDSLPLEVALLYRSLIAFSLFGVMFIFIFKKLKLNNTNWFTIIGFGLCNFTISYLLLYYGTFYSSAAIVTLIFSMKAILTPIFISMVFKRKISNRIYIGGGLGVVSVVVILYPDLNSLTNEFIIGVAFALLGTIITSIGDVLSLYNSESKVHPVLSNTIGMLSAVIFLLIYTSFKGYRYSFPLELNFWFGLLYLSILASFLAWFFYLKLINNIGAAESGYMVAMFPAIGGIASVIMGETHLSINLVVGIILACMGAYLALYKPKPS
>NZ_CP022898.1|WP_000206632.1|2079586_2080810_+|ArgE/DapE-family-deacylase
MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKDGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINNVNSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVNKDDIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK
>NZ_CP022898.1|WP_000791409.1|2078095_2079151_-|bi-component-leukocidin-LukGH-subunit-H
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTVPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNPKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
>NZ_CP022898.1|WP_047213639.1|2077057_2078074_-|bi-component-leukocidin-LukGH-subunit-G
MIKQLYKNITICSLAISTALTVFPATSYAKINSEIKAVSEKNLDGDTKMYTRTATTSDSQKNITQSLQFNFLTESNYDKETVFIKAKGTIGSGLRILEPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHDVKFVKVLNDNEKK
>NZ_CP022898.1|WP_000857174.1|2074624_2075662_+|site-specific-integrase
MKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDNYITLAEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDYSKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEILKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTDTSPRYISIAKSDMKHIMDVISTFAISYDGYIFKEAGFIINLQAINNALKSACRVNNIPIITSHALRHTHCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
>NZ_CP022898.1|WP_000191459.1|2073902_2074517_-|hypothetical-protein
MTQFLGALLLTGVLGYIPYKYLTMIGLVSEKNKIINTPVLLIFSIETCLIWFYTFIIFNNVDLKNLSLLQLLTGLKANIWFLIIFVLTVLVFNPLIVKFIIWLINETRKFMNLDCISLLDKRDKLFNNNGKPVFIVIKDFENRIIEEGELKTYNSAGSDFDLLEVERQDFKVSDLPSNDELYIKHTLVDLKQQIKLDLYLMNEY
>NZ_CP022898.1|WP_001013104.1|2073759_2073906_+|hypothetical-protein
MNGGENFMADKNKKQEATRSNPINKSFEKPGASENLKSTLSEKAKKKD
>NZ_CP022898.1|WP_000694770.1|2073541_2073724_+|hypothetical-protein
MKIKNCKIKKETIVYEVLTSGNQPFTYELPKDLSSHNARKYLEFISQKIDGDKLTKEDSL
>NZ_CP022898.1|WP_001208482.1|2072571_2073342_+|helix-turn-helix-domain-containing-protein
MREKVSNRLKHIMKIRNLKQVDIINKSKPYQKKLGISLSKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWLMGYDVDSYRVPDEERQDETIMSKINNIFSQLTPPRQENVLNYANEQLEEQNKVTSIDGYKESKLVSYIACGATGAGIGEELYDDILHEEVFFKEDETPSNADFCILVNGDSMEPMLKQGTYAFIKKEDSIKDGTIALVVLDGVSLIKRVDICEDYINLVSLNPKYDDIKVASFSDIKVMGKVVL
>NZ_CP022898.1|WP_001045081.1|2084013_2085321_+|TrkH-family-potassium-uptake-protein
MNKVHKPLYFYLMLFFSTTIIGALLLYLPFTGKKPISFLDALFIASSAFTVTGLSPVDIGSQFNILGEIVILLLIQIGGLGIVTVTLLTLVFLNRKISMKNRFLIMVTWNIDEPGGVIKLIKHLAIYSLVTELIGMICLCLSFIPKFGIGKGLFLSLFTSVSAFNNAGFALFKNNLIDYSSDPIVIITISILIIFGGIGHFVVIDFINCKKLSKLSLHSKLVLTTTSILIIIGAITFFLLEQFNTMQNMGLVEKIGNSFFQSVTTRTAGFNSIDIASINKSTALMLMLLMFIGGAPLSASGGIKITTFAVAFIFVLNYIRKENNVSVFNKEISDKHIKLSIVTINISFLFISIITFILSIINPNISLIKLLFEVVSAFGTVGLSMNLTTEYHGITKIIIIFVMLCGKVGLLTLLRTFIPPKSPKNYRYTKGQIYL
>NZ_CP022898.1|WP_047213641.1|2085892_2086519_-|hypothetical-protein
MTVKVISLSELLTGDKQEVKRKIPSVLNILNSFETISISGSESAHDVDLFLKNKSIAFDRQNLSRTHLVFSQFKSKQILVGYFTISNKPLVFTKRMLDKISNTLKKKLYQKGKTHSGNDNLIIQGYLIAQIGKNYSEEALATKSINGNDLLTLAYEKVLEGANIFGGSYIWIDYEDVDRLREFYRKFGFTEIKDHTSENNLKMAILKI
>NZ_CP022898.1|WP_000201394.1|2086515_2086695_-|hypothetical-protein
MATISITTDYKFTKKSAQKLIDAMEINENKSNVNKTNIKATKIKSTCEIENLLKDYRSN
>NZ_CP022898.1|WP_115385577.1|2087238_2088855_-|chaperonin-GroEL
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVTVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAAKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIKAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATNEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>NZ_CP022898.1|WP_031918283.1|2088930_2089215_-|co-chaperone-GroES
MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKKGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
>NZ_CP022898.1|WP_000197641.1|2089389_2090133_+|CPBP-family-intramembrane-metalloprotease
MTRLWASLLTVIIYILSQFLPLLIVTKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVYTQIFGTQQTSPNTERLIVIARKIPLFIFFVSIVGPLLEEYVFRKVIFGELFNAIKGNRIVAFAIATTVSSLIFALAHNDYKFIPIYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP
>NZ_CP022898.1|WP_000120321.1|2090157_2091306_-|hypothetical-protein
MSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNVTSPSVNSEINNNETGTPHESNQTGNEGTNSNSRDANPDSNNVKPDSNNQNPSSDSKPDPNNPNPGPNPKPDPDKPKPNPDPDPKPDPDKPKPNPNPKPDPNKPNPNPSPDPNQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINQLGKEFGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR
>NZ_CP022898.1|WP_000522380.1|2091502_2092129_+|nitroreductase-family-protein
MGLFKKDKKAMTFDNAMEERRSIYNLKDSISISDDELESMIAHAVKHVPSSFNSQSTRIVLLLNDNNNKFWDNTKAILKEVMGENRDFEPTEQKIDNFKHSYGTILFYEDQDVVSGLQEQMPNYYDNFAIWSTQTNAMHQFAIWTALATKGIGASLQHYNPLVDEITSNEFNIPKSWKLIAQMPFGDIREAAGEKTFNPVEDRFVIKK
>NZ_CP022898.1|WP_000867953.1|2092480_2093266_+|carbon-nitrogen-family-hydrolase
MKVQIYQLPIIFGDSSKNETQITQWFEKNMNDEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNNQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGENVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
>NZ_CP022898.1|WP_000046023.1|2093862_2093943_-|delta-hemolysin
MAQDIISTISDLVKWIIDTVNKFTKK

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Crispr_ID: NZ_CP022898_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_5

2213944-2214029

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP022898_5

>merge|NZ_CP022898|5|2213944-2214029|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTATTTTTCAACTTTAGTTGTTAGGGGCTCTTATGCA

>NZ_CP022898|5|5|2213944-2214029|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTATTTTT
CAACTTTAGTTGTTAGGGGCTCTTATGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_047213685.1\|2212835_2213927_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000003759.1\|2211267_2211588_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP022898.1\|WP_000808822.1\|2208816_2209047_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000160304.1\|2204427_2205138_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP022898.1\|WP_047213683.1\|2209077_2210016_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP022898.1\|WP_047213687.1\|2215244_2216372_-\|SAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|366887
NZ_CP022898.1\|WP_000123394.1\|2206772_2208146_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NZ_CP022898.1\|WP_001123308.1\|2205901_2206315_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NZ_CP022898.1\|WP_031927658.1\|2219359_2221165_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP022898.1\|WP_000070865.1\|2205258_2205702_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP022898.1\|WP_001292149.1\|2225562_2225997_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NZ_CP022898.1\|WP_001024091.1\|2210450_2211116_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP022898.1\|WP_000083812.1\|2221845_2223384_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP022898.1\|WP_000927349.1\|2223418_2225551_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP022898.1\|WP_000370936.1\|2217420_2218278_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP022898.1\|WP_001802298.1\|2214432_2214537_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000019739.1\|2211589_2212570_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NZ_CP022898.1\|WP_000908193.1\|2218345_2219128_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP022898.1\|WP_047213691.1\|2227421_2234855_-\|DUF1542-domain-containing-protein	unknown	unknown	gnl\|CDD\|275089
NZ_CP022898.1\|WP_000648717.1\|2225996_2227103_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_000003759.1\|2211267_2211588_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NZ_CP022898.1\|WP_000927349.1\|2223418_2225551_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	5.9991e-68
NZ_CP022898.1\|WP_000160304.1\|2204427_2205138_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NZ_CP022898.1\|WP_047213683.1\|2209077_2210016_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	1.46752e-128
NZ_CP022898.1\|WP_047213687.1\|2215244_2216372_-\|SAP-domain-containing-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	5.97077e-06
NZ_CP022898.1\|WP_000123394.1\|2206772_2208146_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.92966e-06
NZ_CP022898.1\|WP_001123308.1\|2205901_2206315_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	2.52292e-44
NZ_CP022898.1\|WP_000070865.1\|2205258_2205702_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
NZ_CP022898.1\|WP_001024091.1\|2210450_2211116_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.86209e-48
NZ_CP022898.1\|WP_000083812.1\|2221845_2223384_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP022898.1\|WP_001292149.1\|2225562_2225997_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NZ_CP022898.1\|WP_000370936.1\|2217420_2218278_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	2.43638e-59
NZ_CP022898.1\|WP_031927658.1\|2219359_2221165_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP022898.1\|WP_000019739.1\|2211589_2212570_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	8.62765e-109
NZ_CP022898.1\|WP_000908193.1\|2218345_2219128_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.56485e-106
NZ_CP022898.1\|WP_047213691.1\|2227421_2234855_-\|DUF1542-domain-containing-protein	gnl\|CDD\|275089	TIGR04263, cell_wall_surface_anchor_family_protein, SasC/Mrp/FmtB intercellular aggregation domain. This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.	1.37143e-108
NZ_CP022898.1\|WP_000648717.1\|2225996_2227103_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0

>NZ_CP022898.1|WP_047213685.1|2212835_2213927_+|hypothetical-protein
MFTYFKSALKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQNIVIYSQFGQKPPGDVYLKVIAVLLIAAIVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGIYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDNKVVTEPKNTKVETDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP022898.1|WP_000019739.1|2211589_2212570_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NZ_CP022898.1|WP_000003759.1|2211267_2211588_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NZ_CP022898.1|WP_001024091.1|2210450_2211116_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSIIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQVISGEQDIKDALTQFENETD
>NZ_CP022898.1|WP_047213683.1|2209077_2210016_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGKSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQRGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYA
>NZ_CP022898.1|WP_000808822.1|2208816_2209047_-|hypothetical-protein
MKQFLYIALVCSVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NZ_CP022898.1|WP_000123394.1|2206772_2208146_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQINAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NZ_CP022898.1|WP_001123308.1|2205901_2206315_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIQLITSLPNRTKLLGIGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NZ_CP022898.1|WP_000070865.1|2205258_2205702_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NZ_CP022898.1|WP_000160304.1|2204427_2205138_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NZ_CP022898.1|WP_001802298.1|2214432_2214537_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NZ_CP022898.1|WP_047213687.1|2215244_2216372_-|SAP-domain-containing-protein
MSVNARDLLVLHNNVNRLVGEEIFANKCLANNDVQIMNSIKKLIEAELLTTTNDFEVSIYKKTRPELQSILKSFGIKTTGNKPDLIKRIDDNFHIINNLDLPYVYIPTKKGEEILKKTEYLTSFIYSYKISLERAYYMVENYIDENCDDKVAEIYKFEFQRKYDNGEFDFNHGYNFELNMLIDHYKRDVKDYDNARKYSNFYLYFGLRDFLKKLMSNYSYYDSKGNIDLNEIQNDLNRFINSSASGMYERLIYNENLSNNIMFELFKKDTQDYSDLEEQLIEKFINYVVSYVKKESRSNTLIELSKMLEKGYTIDKEKFKKEDEYLSRYIITDINYLKNLESKIGVAIDSRNGEIHLVLDDDSLDKLIKNQKNRQ
>NZ_CP022898.1|WP_000370936.1|2217420_2218278_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NZ_CP022898.1|WP_000908193.1|2218345_2219128_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNVYEPPTTGDVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP022898.1|WP_031927658.1|2219359_2221165_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKSEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NZ_CP022898.1|WP_000083812.1|2221845_2223384_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIVGFKVLAPIMKFIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQAAKVGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NZ_CP022898.1|WP_000927349.1|2223418_2225551_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGEDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHIETKDIDGNTSFENEQTSNLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLALPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NZ_CP022898.1|WP_001292149.1|2225562_2225997_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NZ_CP022898.1|WP_000648717.1|2225996_2227103_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFADKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKVFLSEYAKVDDGLADEIIEAYNSLS
>NZ_CP022898.1|WP_047213691.1|2227421_2234855_-|DUF1542-domain-containing-protein
MNLFRQQKFSIRKFNVGIFSALIATVTFISTNPTTASAAEQNQPAQNQPAQPADANTQPNANAGAQANPTAQPAAPANQGQPAAQPANQGGQANPAGGAAQPNTQPAGQGNQADPNNAAQAQPGNQAAPANQAGQGNNQATPNNNATPANQTQPANAPAAAQPAANAQTQDPNASNTGEGSINTTLTFDDPAISTDENRQDPTVTVTDKVNGYSLINNGKIGFVNSELRRSDMFDKNNPQNYQARGNVAALGRVNANDSTDHGNFNGISKTVNVKPDSELIINFTTMQTNSKQGATNLVIKDAKKNTELATVNVAKTGTAHLFKVPTDADRLDLQFIPDNTAVADASRITTNKDGYKYYSFIDNVGLFSGSHLYVKNRDLAPKATNNKEFTINTEIGNNGNFGASLKADQFKYEVTLPQGVTYVNDSLTTTFPNGNEDSTVLKNMTVNYDQNANKVTFTSQGVTTARGTHTKEVLFPDKSLKLSYKVNVANIDTPKNIDFNEKLTYRTASDVVINNAQPEVTLTADPFSVAVEMNKDALQQQVNSQVDNSHYTTASIAEYNKLKQQADNILNEDANHVETANRASQAAIDGLVTKLQAALIDNQAAIAELDAKAQEKVTAAQQSKKVTQDEVAALVTKINNDKNNAIAEINKQTTSQGVTTEKDNGIAVLEQDVITPTVKPQAKQDIIQAVTTRKQQIKKSNASLQDEKDVANDKIGKIETKAIKDIDAATTNAQVEAIKTKAINDINQTAPATTAKAAALEEFDEVVQAQIDQAPLNPDTTNEEVAEAIERINAAKVSDVKAIEATTTAQDLERVKNEEISKIENITDSTQTKMDAYNDVKQAATARKAQNATVSNATNEEVAEADAAVEAAQKQGLHDIQVVKSKQEVADTKSKVLDKINAIQTQAKVKPAADTEVENAYNTRKQEIQNSNASTTEEKQAAYTELDTKKQEARTNLDAANTNSDVTTAKDNSIAAINQVQAATTKKSDAKAEIAQKASERKTAIEAMNDSTTEEQQAAKDKVDQAVVTANTDIDNAAANTDVDNAKTTNEATIAAITPDANVKPTAKQAIADKVQAQETAIDAYNGATTEEKAAAKQQVQTEKTTADAAIDGAHSNAEVEAAKNAEIAKIEAIQPATTTKDDAKQAITTKANERKAAIAQTQDITAEEIAAANADVDNAVTQANSNIEAANSQNDVDQAKTTGETSIDQVTPTVNKKATARNEITTILNNKLQAIQATPDATDEEKQAADAEANTENGKANQAISAATTNAQVDEAKANAEVAINAVTPKVVKKQAAKDEIDQLQVAQTSVINNDQNATNEEKEAAIQQLATAVTDAKNNITAATDDNGVDQAKDAGKNSIQSTQPATAVKSNAKNEVDQAVTTQNQAIDNTTGATTEEKNAAKDLVLKAKEKAYQDILNAQTTNDVTQIKDQAVADVQGITADTTIKDVAKDELATKANEQKALIAQTADATTEEKEQANQQVDAQLTQGNQNIENAQSIDDVNTAKDNAIQAIDPIQASTDVKTNARAELLTEMQNKITEILSDNTTTNEEKGKDIEPVRATYEEGLNNINTANTTGDVTTAKDTAVQKVQQLHANPVKKPAGKTALDQAAADRKTQIEQTPNASQQEINDAKQEVDATLNQAKTNVDQSSTNEYVDNAVKEGKAKINAVKTFSEYKKDALAKIEAAYNSKVNEADNSNASTSSEIAEAKQKLAELKQTADQNVNQATSKDDIEVQIHNDLDNINDYTIPTGKKETATTDLYAYADQKKNNISADTNATQDEKQQAIKQVDQNVQTALESINNGVDNGDVDDALTQGKAAIDAIQVDATVKPKANQAIEAKAEDTKESIDHSDQLTAEEKTEALAMIKQITDQAKKGINDATTTAEVEKAKAQGLEAFDNIQIDSTEKQKAIEELETALDQIEAGVNVDADATTEEKEAFTNALEDILSKATEDISDQTTNAEIATVKNSALEQLKAQRINPEVKKNALEAIREVVNKQIEIIKNADASAKEIARTDLGRYFDRFADNLDKTQTNAEVAELQNVTIPAIEAIVPQNDPDANDTNNGTDNNDATANSNANATPENTGQPNVSETTDNGKADASPTTPNNSDAATGETTATSTNNPSTDDANNKPTANNNSSVDASTDNSATGNGTIDKPEVESTNNGTTDKPATETDNVTPAESTTNNNSTTATNENAPTGSTATAPTTASTEAASSADSKDNAFVNDSKQNAEVNNSAESQSTNGMVVQPKSENKAKAEKDGRDSTNQSMVESTTETLPSADITEPKVPSNTSKDKEESTTNQTDAGHLKSETNVASNEVDKSEGNVDTDVSNKPSTSKPSEAKDKATSTEDSQKADMATADTKDNQAAIGATADVNNKATQNDGANASPATVSNGSNSTNQDMLNVTKTEENKANVKSAQQGKVNKPKQQAKTLPDTGMSHNDDLPYAELALGAGMAFLIRRFTKKDQQTEE

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Crispr_ID: NZ_CP022898_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_6

2331311-2331399

Orphan

Consensus_repeat	Method
GTTCCCCAACTTGCACATTATTGTATGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_6

>merge|NZ_CP022898|6|2331311-2331399|CRISPRCasFinder
GTTCCCCAACTTGCACATTATTGTATGCTGACTTTTGTCAGCTTCTGTGTTGGGGCCCCGTTCCCCAACTTGCACATTATTGTAAGCTG

>NZ_CP022898|6|6|2331311-2331399|CRISPRCasFinder
GTTCCCCAACTTGCACATTATTGTATGCTG	ACTTTTGTCAGCTTCTGTGTTGGGGCCCC
GTTCCCCAACTTGCACATTATTGTAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_000066900.1\|2330649_2331000_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NZ_CP022898.1\|WP_047212897.1\|2322794_2325962_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP022898.1\|WP_001566779.1\|2327732_2327984_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000259726.1\|2334410_2335670_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_CP022898.1\|WP_000230173.1\|2331581_2332604_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250
NZ_CP022898.1\|WP_000503814.1\|2336228_2336735_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NZ_CP022898.1\|WP_000913013.1\|2337938_2338544_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NZ_CP022898.1\|WP_000602951.1\|2333928_2334414_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
NZ_CP022898.1\|WP_000051210.1\|2321891_2322056_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000076926.1\|2336765_2337770_-\|molybdopterin-biosynthesis-protein-MoeB	unknown	unknown	gnl\|CDD\|181084
NZ_CP022898.1\|WP_000134534.1\|2335732_2336227_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NZ_CP022898.1\|WP_000413855.1\|2326078_2327344_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NZ_CP022898.1\|WP_000951066.1\|2328903_2329344_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NZ_CP022898.1\|WP_000643988.1\|2332623_2333223_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725
NZ_CP022898.1\|WP_001161080.1\|2322290_2322608_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000600967.1\|2327975_2328740_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NZ_CP022898.1\|WP_000866967.1\|2333229_2333463_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NZ_CP022898.1\|WP_000808500.1\|2333468_2333915_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NZ_CP022898.1\|WP_031927354.1\|2331125_2331296_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000184421.1\|2329336_2330548_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_000066900.1\|2330649_2331000_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NZ_CP022898.1\|WP_047212897.1\|2322794_2325962_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP022898.1\|WP_000259726.1\|2334410_2335670_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	9.192e-158
NZ_CP022898.1\|WP_000230173.1\|2331581_2332604_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
NZ_CP022898.1\|WP_000503814.1\|2336228_2336735_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	1.92933e-64
NZ_CP022898.1\|WP_000602951.1\|2333928_2334414_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	1.7369e-49
NZ_CP022898.1\|WP_000076926.1\|2336765_2337770_-\|molybdopterin-biosynthesis-protein-MoeB	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	1.97922e-131
NZ_CP022898.1\|WP_000134534.1\|2335732_2336227_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	2.70933e-97
NZ_CP022898.1\|WP_000413855.1\|2326078_2327344_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	8.95714e-143
NZ_CP022898.1\|WP_000951066.1\|2328903_2329344_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.06862e-14
NZ_CP022898.1\|WP_000913013.1\|2337938_2338544_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	1.84496e-113
NZ_CP022898.1\|WP_000600967.1\|2327975_2328740_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
NZ_CP022898.1\|WP_000866967.1\|2333229_2333463_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	5.99629e-25
NZ_CP022898.1\|WP_000808500.1\|2333468_2333915_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	5.56799e-58
NZ_CP022898.1\|WP_000643988.1\|2332623_2333223_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	5.68918e-67
NZ_CP022898.1\|WP_000184421.1\|2329336_2330548_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.81635e-72

>NZ_CP022898.1|WP_031927354.1|2331125_2331296_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNGMECDTNVKEPLKIYYVVILKSGIEMIFS
>NZ_CP022898.1|WP_000066900.1|2330649_2331000_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NZ_CP022898.1|WP_000184421.1|2329336_2330548_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETNVIDKPSFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NZ_CP022898.1|WP_000951066.1|2328903_2329344_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKYQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>NZ_CP022898.1|WP_000600967.1|2327975_2328740_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NZ_CP022898.1|WP_001566779.1|2327732_2327984_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLAIIHMGILAHSTYVYLY
>NZ_CP022898.1|WP_000413855.1|2326078_2327344_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NZ_CP022898.1|WP_047212897.1|2322794_2325962_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASASNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMIEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILLATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHADGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NZ_CP022898.1|WP_001161080.1|2322290_2322608_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVIFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NZ_CP022898.1|WP_000051210.1|2321891_2322056_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDLEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NZ_CP022898.1|WP_000230173.1|2331581_2332604_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NZ_CP022898.1|WP_000643988.1|2332623_2333223_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NZ_CP022898.1|WP_000866967.1|2333229_2333463_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIMLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NZ_CP022898.1|WP_000808500.1|2333468_2333915_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NZ_CP022898.1|WP_000602951.1|2333928_2334414_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRYIVSFLKSHGYTVATIKHHGHGKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRNEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NZ_CP022898.1|WP_000259726.1|2334410_2335670_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NZ_CP022898.1|WP_000134534.1|2335732_2336227_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIYKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
>NZ_CP022898.1|WP_000503814.1|2336228_2336735_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRDFDTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKLAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NZ_CP022898.1|WP_000076926.1|2336765_2337770_-|molybdopterin-biosynthesis-protein-MoeB
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDDYIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKHRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSACTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NZ_CP022898.1|WP_000913013.1|2337938_2338544_-|ATP-binding-cassette-domain-containing-protein
MLKINLKYQLKNTLIRININDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTAKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSEHIDQLIQTLNIDHLMKQYPMTLSGGEAQRVSLARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Crispr_ID: NZ_CP022898_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_7

2394077-2394170

Orphan

Consensus_repeat	Method
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_7

>merge|NZ_CP022898|7|2394077-2394170|CRISPRCasFinder
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGCGTAGTCAACTGTATACCTTTTGCCTTTAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC

>NZ_CP022898|7|7|2394077-2394170|CRISPRCasFinder
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC	GTAGTCAACTGTATACCTTTTGCCTT
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_000634685.1\|2399228_2400248_-\|galactose-mutarotase	unknown	unknown	gnl\|CDD\|185696
NZ_CP022898.1\|WP_031927708.1\|2388735_2389857_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349919
NZ_CP022898.1\|WP_000966695.1\|2400277_2400604_-\|YnfA-family-protein	unknown	unknown	gnl\|CDD\|224656
NZ_CP022898.1\|WP_047212922.1\|2402046_2402946_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226631
NZ_CP022898.1\|WP_000548682.1\|2400821_2402054_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224582
NZ_CP022898.1\|WP_001185201.1\|2386684_2387257_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000730052.1\|2387743_2388625_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181188
NZ_CP022898.1\|WP_000451828.1\|2385146_2386460_-\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NZ_CP022898.1\|WP_000998761.1\|2390134_2391373_-\|imidazolonepropionase	unknown	unknown	gnl\|CDD\|236478
NZ_CP022898.1\|WP_000277973.1\|2394936_2395872_-\|formimidoylglutamase	unknown	unknown	gnl\|CDD\|184317
NZ_CP022898.1\|WP_031927709.1\|2396161_2397418_+\|CPBP-family-intramembrane-metalloprotease-SdpC	unknown	unknown	gnl\|CDD\|224185
NZ_CP022898.1\|WP_000991505.1\|2381717_2383322_-\|PTS-transporter-subunit-EIIC	unknown	unknown	gnl\|CDD\|273925
NZ_CP022898.1\|WP_072357721.1\|2400652_2400838_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000623457.1\|2398339_2398993_+\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NZ_CP022898.1\|WP_000904065.1\|2381121_2381652_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000436826.1\|2403176_2403833_-\|DUF805-domain-containing-protein	unknown	unknown	gnl\|CDD\|225694
NZ_CP022898.1\|WP_000477989.1\|2383651_2384416_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP022898.1\|WP_001051556.1\|2384473_2384980_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226353
NZ_CP022898.1\|WP_000655867.1\|2397482_2398169_-\|ribose-5-phosphate-isomerase-A	unknown	unknown	gnl\|CDD\|184433
NZ_CP022898.1\|WP_001226823.1\|2391372_2393034_-\|urocanate-hydratase	unknown	unknown	gnl\|CDD\|235448

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_000634685.1\|2399228_2400248_-\|galactose-mutarotase	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	9.6517e-99
NZ_CP022898.1\|WP_031927708.1\|2388735_2389857_-\|amidohydrolase	gnl\|CDD\|349919	cd05669, M20_Acy1_YxeP-like, M20 Peptidase aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2. Peptidase M20 family, aminoacyclase-1 YxeP-like subfamily including YxeP, YtnL, YjiB and HipO2, most of which have not been well characterized to date. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity; substrates include indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). ACY1 appears to physically interact with Sphingosine kinase type 1 (SphK1) and may influence its physiological functions; SphK1 and its product sphingosine-1-phosphate have been shown to promote cell growth and inhibit apoptosis of tumor cells. Strong expression of the human gene and its mouse ortholog Acy1 in brain, liver, and kidney suggest a role of the enzyme in amino acid metabolism of these organs.	0
NZ_CP022898.1\|WP_000966695.1\|2400277_2400604_-\|YnfA-family-protein	gnl\|CDD\|224656	COG1742, COG1742, Uncharacterized conserved protein [Function unknown].	2.59201e-46
NZ_CP022898.1\|WP_047212922.1\|2402046_2402946_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226631	COG4152, COG4152, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	1.00969e-170
NZ_CP022898.1\|WP_000548682.1\|2400821_2402054_-\|ABC-transporter-permease	gnl\|CDD\|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	1.87659e-72
NZ_CP022898.1\|WP_000730052.1\|2387743_2388625_-\|SDR-family-oxidoreductase	gnl\|CDD\|181188	PRK07985, PRK07985, SDR family oxidoreductase.	4.22697e-133
NZ_CP022898.1\|WP_000451828.1\|2385146_2386460_-\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	2.62746e-90
NZ_CP022898.1\|WP_000998761.1\|2390134_2391373_-\|imidazolonepropionase	gnl\|CDD\|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0
NZ_CP022898.1\|WP_000277973.1\|2394936_2395872_-\|formimidoylglutamase	gnl\|CDD\|184317	PRK13774, PRK13774, formimidoylglutamase; Provisional.	0
NZ_CP022898.1\|WP_031927709.1\|2396161_2397418_+\|CPBP-family-intramembrane-metalloprotease-SdpC	gnl\|CDD\|224185	COG1266, COG1266, Predicted metal-dependent membrane protease [General function prediction only].	4.08308e-11
NZ_CP022898.1\|WP_000991505.1\|2381717_2383322_-\|PTS-transporter-subunit-EIIC	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
NZ_CP022898.1\|WP_000623457.1\|2398339_2398993_+\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	1.13942e-88
NZ_CP022898.1\|WP_000436826.1\|2403176_2403833_-\|DUF805-domain-containing-protein	gnl\|CDD\|225694	COG3152, COG3152, Predicted membrane protein [Function unknown].	1.59825e-23
NZ_CP022898.1\|WP_000477989.1\|2383651_2384416_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.91257e-62
NZ_CP022898.1\|WP_001051556.1\|2384473_2384980_-\|hypothetical-protein	gnl\|CDD\|226353	COG3832, COG3832, Uncharacterized conserved protein [Function unknown].	4.34585e-27
NZ_CP022898.1\|WP_000655867.1\|2397482_2398169_-\|ribose-5-phosphate-isomerase-A	gnl\|CDD\|184433	PRK13978, PRK13978, ribose 5-phosphate isomerase A.	7.0255e-156
NZ_CP022898.1\|WP_001226823.1\|2391372_2393034_-\|urocanate-hydratase	gnl\|CDD\|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	0

>NZ_CP022898.1|WP_001226823.1|2391372_2393034_-|urocanate-hydratase
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIHQAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISFHHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
>NZ_CP022898.1|WP_000998761.1|2390134_2391373_-|imidazolonepropionase
MNDLIINHIAELILPRSTDKPLKGKELDELNVVKNGTVVIKDGKIVYAGQHTDDYDATETIDASGKVVSPALVDAHTHLTFGGSREHEMSLKRQGKSYLEILEMGGGILSTVNATRETSEDDLFKKAEHDLLTMIKHGVLAVESKSGYGLDRENELKQLKVSNRLAEKYDLDMKHTFLGPHAVPKEASSNEAFLEEMIALLPEVKQYADFADIFCETGVFTIEQSQHYMQKAKEAGFKVKIHADEIDPLGGLELAIDEQAISADHLVASSDKGKEKLRNSDTVAVLLPATTFYLGKEDYADARGMLDNNGAIALATDYNPGSSVTNNLQLVMAIAALKLKLSPNEVWNAVTVNAAKAIDINAGTINTGDKANLVIWDAPNHEYIPYHFGINHAEKVIKDGKVIVDNTLSFKA
>NZ_CP022898.1|WP_031927708.1|2388735_2389857_-|amidohydrolase
MGLKDQAVAWRRYFHQFPELSDKEFKTTQKIKDILTEHHIRILDLPLATGLVAEVGQGPSCIAVRADIDALPIQELVEQDFKSENEGVMHACGHDIHMASILATAVKLKEIEGTLTGRVKFIFQPAEELGYGAFKIIETHALKDVQAVLGFHNDPSRPVSTFAIKTGAITSAVDRFEFHIKGVGGHAAKPEQCNDPVIVLAQLINSIQSIVSRNLSAFHEAVVTIGQISCGNTWNVIADHAYVQGTVRSFDPVVRKLVETRLQDIADGLAQAYNMKINLNYTHLPGAVMNDEALTHKAIAVAQHVGYKVEMMEQPLTIGEDFSGYSQHFPSVFALIGSHSEYDLHHPQYKPDERILEKVPEYFVEFVKRLLHE
>NZ_CP022898.1|WP_000730052.1|2387743_2388625_-|SDR-family-oxidoreductase
MAAQDPRTKFKTTDYEKQEQEVPGLQSEMTPAPDCGETSYQGHQRLQSYKMLVTGGDSAIGRAAAIAYAKEGADVAINYLPSEEQDAQEVRQVIEESGQKAVLIPGDIRDEQFNYDLVEQAYQQLGGLDNVTLVAGHQQYHDDIHGFTTEAFTETFETNVYPLFWTVQKALEYLKPGASITTTSSVQGYNPSPILHDYAASKAAIISLTKSFSEELGPKGIRVNCVAPGPFWSPLQISGGQPQSKIPTFGQKTPLGRAGQPVELCGTYVLLASEESSYTTGQVFGVSGGVQID
>NZ_CP022898.1|WP_001185201.1|2386684_2387257_-|hypothetical-protein
MALIVSRAILFLILALAFGIATVFPEQKLSLYIVFTLFVAVAIIMNVWFTHQNIKKNIIKFNKYVAFFLAFVSGLLYIGFVIYTLTIGSYDVLPIIIFAISIVLVQILENILGISIRNTRPSNKQLKVISEQSAQQFKVISLILVSVSIVFIFIALMLKWWLILAISIIVLIIIITVAMIVYEKYYTTPD
>NZ_CP022898.1|WP_000451828.1|2385146_2386460_-|Na+/H+-antiporter-NhaC-family-protein
MEVHKKSNAWALFPLLLFVALFLGVGIITGDFTSMPLNVAITITVIVALLMNRKESFAKKVEVFTKGAGHSNIILMMLIFILAGAFSNTAEKMGGVKSTVNLGLSLIPENLIIVGLFVICMFVSISMGTSVGTVAAIAPVGYGFAQATDVPTALAMATVVGGAMFGDNLSMISDTTIAAVRTQHTKMKDKFRVNFKIVLPGAILTIIILYFLTNGISLNHAKNYDYNLIKVVPYILVLVLALLGVNVIIVLIGGTLLAGIIGLIDGSFGWMGLLDAVSKGIISMEDIAMIALLIGGLVGIIQHNGGIEWLLQFVRSKVKSKRGAELGIASLVSVADIATANNTISIIMSGPLAKNIADEYDVDSRKSASILDIFGGCFQGLLPYSPQVISAAGVAGISPLMLFPYSIYPILLGVCGLIAILFNFPKLKKNTSQEMKH
>NZ_CP022898.1|WP_001051556.1|2384473_2384980_-|hypothetical-protein
MAKFNVENEHVEVEIEKLYKFSPELVYEAWTKKDLLKQWFMTSARTNKEIEADVKEGGKYRIVDQQRNGKVNVIEGIYESLVMDEYVKMTIGMPGLSETQDVIEVEFFERETGGTQMLFYYRSLVEKERRFTNLEYKQKKKEYHDAMVHGFELMFDKMYHVIETSTQQ
>NZ_CP022898.1|WP_000477989.1|2383651_2384416_+|MurR/RpiR-family-transcriptional-regulator
MFLDEHINRNFDKLNDNDLHIAHFINTHIDECKNMKIQDLAQFTHASNATIHRFTRKLGFDGYSDFKSYLKFESNKTHQLPSNSIDSFKQEIDSTFSYLERVDYQLLTEKMHTASTIYLYGTGRAQLNVASEAQRILLTLHNHVIVLHDEHELKMILNKSEPNDLFFIISLSGETHELLEVTNLLQLRQKYFISVTTMKDNTLAQKANYNVYVSSNTFYLTDGTDYSSFISYHIFFETLVRKYNEYLLHNDISN
>NZ_CP022898.1|WP_000991505.1|2381717_2383322_-|PTS-transporter-subunit-EIIC
MNAIKRFGSAMIVPVLMFAFFGIVLGFATLFKNPTIMGSLADQHTFWFKFWSVIESGGWVIFTHMEVVFVVGLPLSLAKKAPGHAALAALMGYLMFNTFINAILTQWPHTFGANLEKGVENVPGLKSIAGIATLDTNILGGIIISAIITWIHNRYYSKRLPEMVGVFQGLTFVVTISFFVMLPLAAITCVIWPTVQHGIGSMQHFIIASGYIGVWLYHFLERVLIPTGLHHFIYAPIEVGPVVVNHGLKAEWLQHLNEFAKSTKPLKEQFPYGFMLQGNGKVFGCLGIALAMYATTPKENRKKVAALLIPATLTAVVVGITEPLEFTFLFIAPYLFVLHAVLAASMDTLMYAFGVVGNMGGGLLDFISTNWLPLGKEHWGTYVAQVVIGLIFVAIYFFLFRFLILKFDIPLPGRKKTEEEVKLFSKQDYKNKKGDSVDSKRASTGNEYEDKAAYYLDGLGGKENIKDVTNCTTRLRLTVYDESKVADTEYFTHQQMAHGLVKSGKSIQVVVGMTVPQVREAFEQMVDDQSSEDK
>NZ_CP022898.1|WP_000904065.1|2381121_2381652_+|hypothetical-protein
MLIDKFETYIINIAGLNDRTTRKKLSKLCKSVQFCDALQFSINKQFNQYVLEISLPKQQLPYFISFLSFHQYSIFQVLSPKKINELLDSDNLYQSAKRFDINIDGLQDAFIKDKVIDIMNMFQNHTDITYTLNKSHAHIICTPEIFAKLLHTIATRNIDILSANYRSSSMSKARIS
>NZ_CP022898.1|WP_000277973.1|2394936_2395872_-|formimidoylglutamase
MYKQGEPNLWTGRLDSETDPKKFRHFQTVTFEDLSKLEKSSRPSGVGILGYAVDEGVALNKGRIGAKEGPDAIKQAFAGLPDLNQCETLVDYGNVYHDHEELIDTQKEFAMLAAKSIANHRQTFLLGGGHDIAYAQYLATRKVYPTQSIGVINIDAHFDTRAEQQSTSGTSFRQILEEDENTDYLVLGIAQGGNTQSLFDYAKEKKIDYVFADELLSHVSPTIKDMIERFVHEHDVIMFTICMDVIDSAFAPGVSAPAVLGLYPHTVLELAKRIIPSDKVSSVSIAEMNPTYDADNRTAKLVANLVHHFLK
>NZ_CP022898.1|WP_031927709.1|2396161_2397418_+|CPBP-family-intramembrane-metalloprotease-SdpC
MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILVFKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPITHILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYNFLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAIVAVGYIGLSLIIRGVAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKTGVATASTVGIAKNDTEKTVADEPSIHEGTEKTEPQHHIDNQTESNHDEHHDITSESVESAESVKHAPQSDDLTNDSNEDEIQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
>NZ_CP022898.1|WP_000655867.1|2397482_2398169_-|ribose-5-phosphate-isomerase-A
MKDVKALKLMTLNDVLSQINGDMTLGIGTGSTMELLLPQMAQLIKERGYNITGVCTSNKIAFLAKELGIKICEINDVDHIDLAIDGADEVDPSLNIIKGGGGALFREKVIDEMASRFVVVVDETKMVQYLGETFKLPVEVDKFNWYHILRKIESYADIKVERRVNEDVAFITDNGNYILDCKLPKGIDPYKFHEYLIHLTGVFETGYFLDMADQVIVGTQEGVKILEK
>NZ_CP022898.1|WP_000623457.1|2398339_2398993_+|MOSC-domain-containing-protein
MISIHVISTGKIQDLPYSSKRPMRSALDKTKISQTTWLSSTGFTGDEQAYKDHGGPHKAVCGFSKHNYALYQDDLPSLPTHAMFGENLTFDYLDESDVYFGNQYRLGEALIEVSEIREPCWKIQAKYNIPDLVKRMSTSGKTGFYFRVLKQGYVSPNDQLYLIQEAPIEHRLSVQQLNDLYYNDRQNQDMLRYALNNPFLSPTRRDKLQKMYNRTLK
>NZ_CP022898.1|WP_000634685.1|2399228_2400248_-|galactose-mutarotase
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPFKFGASIGRYSGRIDNAKFKLKGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIKVIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVASEDTLFSPTNHVYFNLNRDNNVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRFGGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLETQFLPNDINLYGEKAPSILKAGEVFNSKTSFRIEEKVEND
>NZ_CP022898.1|WP_000966695.1|2400277_2400604_-|YnfA-family-protein
MLYPIFIFILAGLCEIGGGYLIWLWLREGQSSLVGLIGGAILMLYGVIATFQSFPSFGRVYAAYGGVFIIMSLIFAMVVDKQMPDKYDVIGAIICIVGVLVMLLPSRA
>NZ_CP022898.1|WP_072357721.1|2400652_2400838_-|hypothetical-protein
MYLKNKIDESDTHLSYKMVMKACYSYFFIFSYRIMSKKVYNMNVKTNFLKWECEVRRNVNE
>NZ_CP022898.1|WP_000548682.1|2400821_2402054_-|ABC-transporter-permease
MHKFWATFSLTYIKKIKAKSFVIFMIIIAALMIGLSNIDKIINMFDDGPDKIGVAAPNEQIYKVFKQQANTFHSDAKFTKVSIEDAEKEVKKHKLDKAYIIKVNQNRTLQGTIISEKRVSHEDSQKVQALLTAIQTNMVAGELNINKEDLQKLQAQSKVDNKVISNDEVDKVSEGQKIFNYALAYGIIFLMFFIVLNYASQIAMEIASEKTSRVIEMIITSISPIQHIFAKILGVIAVAVTQIILIVLMAVICIFAFDLKDLLQGFNVEMNQLSWQIIIVGIISSIVGIMAYVLLAAILGSLTSRIEDLNQSLMPLTLLGMIAFYIAIFTINNPDGQLALITSYIPFLAPFQLVVRAQTSGLQIHEVILSSLISIVMVAVLIWIAIKTYKDSVLTFERGLFNSMKRVFKK
>NZ_CP022898.1|WP_047212922.1|2402046_2402946_-|ABC-transporter-ATP-binding-protein
MGLVIEHVTKRFGKMTAVNDISLELESGKMLGFLGRNGAGKTTTFRMILGLSEPTEGHITYNGKKLDKTMYNRIGYLPEERGLHGKLTVEEELKYLATLKGMSKTEIQQQISYWLERFDITENRKKRIDSLSKGNQQKIQLLASMLHKPELLILDEPFSGLDPVNVELLKEAFKDLNDWGSTIVYSSHRMEHVEELCDDVCILDKGQLVVSGDINHVRASNGNKKVVIESETTLPDLTHIRGIIHSENMKQGIQLTIENEDVAKDIYQVVAYQGYVKRFQVVEPSLQDIFIEKVGGKDA
>NZ_CP022898.1|WP_000436826.1|2403176_2403833_-|DUF805-domain-containing-protein
MEQLPQVGFMKSFVLFWKNYVNFKGRSRRSEYWYMMLWHLIFILPAFFVFFMGAVFVGIGDEIDAKVLSMFGVMILILTIIYMLLYSLATFIPNLALSVRRFHDISRTVVLPIIMCAFSIVFSIVVQFIESYYDNDFMFMPIGIVILLVLLYLIYFGLTVTMIVFLCFDSKPANKYGESPKYPSSIKNQPVTSETPEKAGTSETPKTPKTPEETDNQL

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Crispr_ID: NZ_CP022898_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_8

2480875-2480966

Orphan

Consensus_repeat	Method
TGCGTTCCTTTATTTTCTGCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_8

>merge|NZ_CP022898|8|2480875-2480966|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTTATTTTCTGCGAA

>NZ_CP022898|8|8|2480875-2480966|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAA	TTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAAC
TGCGTTCCTTTATTTTCTGCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_001046645.1\|2488926_2489934_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_CP022898.1\|WP_000792566.1\|2481376_2482687_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|288473
NZ_CP022898.1\|WP_000783428.1\|2485623_2486601_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NZ_CP022898.1\|WP_047212940.1\|2479803_2480670_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP022898.1\|WP_000038972.1\|2476919_2478359_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NZ_CP022898.1\|WP_000825931.1\|2476019_2476799_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NZ_CP022898.1\|WP_031927725.1\|2489935_2491294_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_CP022898.1\|WP_000819846.1\|2472627_2472990_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
NZ_CP022898.1\|WP_000479576.1\|2475319_2476039_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP022898.1\|WP_000971544.1\|2487833_2488949_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NZ_CP022898.1\|WP_047212943.1\|2484674_2485622_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
NZ_CP022898.1\|WP_001807148.1\|2481162_2481282_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000200954.1\|2486652_2487120_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NZ_CP022898.1\|WP_000615459.1\|2474591_2475323_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP022898.1\|WP_000762708.1\|2478532_2478637_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000594519.1\|2483176_2484106_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NZ_CP022898.1\|WP_000162805.1\|2472009_2472609_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NZ_CP022898.1\|WP_031927724.1\|2487130_2487823_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
NZ_CP022898.1\|WP_001012216.1\|2473244_2474495_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NZ_CP022898.1\|WP_001125208.1\|2478790_2479477_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_001046645.1\|2488926_2489934_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_CP022898.1\|WP_000792566.1\|2481376_2482687_+\|hypothetical-protein	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.01337e-26
NZ_CP022898.1\|WP_000783428.1\|2485623_2486601_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
NZ_CP022898.1\|WP_047212940.1\|2479803_2480670_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	7.66469e-90
NZ_CP022898.1\|WP_000038972.1\|2476919_2478359_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.56422e-92
NZ_CP022898.1\|WP_000825931.1\|2476019_2476799_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.35689e-100
NZ_CP022898.1\|WP_031927725.1\|2489935_2491294_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_CP022898.1\|WP_000819846.1\|2472627_2472990_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.44071e-31
NZ_CP022898.1\|WP_000479576.1\|2475319_2476039_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.98247e-78
NZ_CP022898.1\|WP_000971544.1\|2487833_2488949_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	9.08937e-138
NZ_CP022898.1\|WP_000200954.1\|2486652_2487120_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00118414
NZ_CP022898.1\|WP_000615459.1\|2474591_2475323_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.20318e-144
NZ_CP022898.1\|WP_047212943.1\|2484674_2485622_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.1102e-93
NZ_CP022898.1\|WP_000594519.1\|2483176_2484106_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.31899e-97
NZ_CP022898.1\|WP_000162805.1\|2472009_2472609_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	6.8825e-31
NZ_CP022898.1\|WP_031927724.1\|2487130_2487823_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	2.10153e-129
NZ_CP022898.1\|WP_001012216.1\|2473244_2474495_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NZ_CP022898.1\|WP_001125208.1\|2478790_2479477_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167

>NZ_CP022898.1|WP_047212940.1|2479803_2480670_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNALRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NZ_CP022898.1|WP_001125208.1|2478790_2479477_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NZ_CP022898.1|WP_000762708.1|2478532_2478637_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NZ_CP022898.1|WP_000038972.1|2476919_2478359_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGITIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGIALVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>NZ_CP022898.1|WP_000825931.1|2476019_2476799_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVMIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKVDDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NZ_CP022898.1|WP_000479576.1|2475319_2476039_-|amino-acid-ABC-transporter-permease
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NZ_CP022898.1|WP_000615459.1|2474591_2475323_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELKRFLNVINEE
>NZ_CP022898.1|WP_001012216.1|2473244_2474495_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHKVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKQNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVKTYLNHKRR
>NZ_CP022898.1|WP_000819846.1|2472627_2472990_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYNFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>NZ_CP022898.1|WP_000162805.1|2472009_2472609_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDDHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NZ_CP022898.1|WP_001807148.1|2481162_2481282_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYGEMQWFANK
>NZ_CP022898.1|WP_000792566.1|2481376_2482687_+|hypothetical-protein
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVQKHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNIFSSFTSFFK
>NZ_CP022898.1|WP_000594519.1|2483176_2484106_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NZ_CP022898.1|WP_047212943.1|2484674_2485622_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLRNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>NZ_CP022898.1|WP_000783428.1|2485623_2486601_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NZ_CP022898.1|WP_000200954.1|2486652_2487120_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NZ_CP022898.1|WP_031927724.1|2487130_2487823_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQKLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLHHYISFLESTPKQVVYETV
>NZ_CP022898.1|WP_000971544.1|2487833_2488949_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDLVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED
>NZ_CP022898.1|WP_001046645.1|2488926_2489934_-|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN
>NZ_CP022898.1|WP_031927725.1|2489935_2491294_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYDAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRNLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

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Crispr_ID: NZ_CP022898_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_9

2763333-2763434

Orphan

Consensus_repeat	Method
TGAGTCAGATACACTCGTTGAACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_9

>merge|NZ_CP022898|9|2763333-2763434|CRISPRCasFinder
TGAATTAGATTCACTCATTGATGTTGAGTCAGATACACTCGTTGAACCAGATGTACTTAAGGAACTAGACGTACTCGATGAGTCAGATACGCTCGTTGAACC

>NZ_CP022898|9|9|2763333-2763434|CRISPRCasFinder
TGAATTAGATTCACTCATTGATGT	TGAGTCAGATACACTCGTTGAACCAGATGTACTTAAGGAACTAGACGTACTCGA
TGAGTCAGATACGCTCGTTGAACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_000301937.1\|2774786_2775263_-\|peptide-methionine-(S)-S-oxide-reductase	unknown	unknown	gnl\|CDD\|235497
NZ_CP022898.1\|WP_047213026.1\|2754710_2757101_-\|accessory-Sec-system-translocase-SecA2	unknown	unknown	gnl\|CDD\|163426
NZ_CP022898.1\|WP_000556736.1\|2774096_2774708_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NZ_CP022898.1\|WP_115385598.1\|2758027_2759596_-\|accessory-Sec-system-protein-Asp2	unknown	unknown	gnl\|CDD\|274739
NZ_CP022898.1\|WP_000565312.1\|2776000_2776768_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|226870
NZ_CP022898.1\|WP_103225775.1\|2747134_2748702_+\|IS3-like-element-ISSau2-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP022898.1\|WP_001151911.1\|2749697_2751593_-\|cell-wall-anchored-protein-SasF	unknown	unknown	unknown
NZ_CP022898.1\|WP_000856195.1\|2773201_2773504_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000593168.1\|2751833_2753192_-\|accessory-Sec-system-glycosylation-chaperone-GtfB	unknown	unknown	gnl\|CDD\|274351
NZ_CP022898.1\|WP_000916733.1\|2757090_2758050_-\|accessory-Sec-system-protein-Asp3	unknown	unknown	gnl\|CDD\|163423
NZ_CP022898.1\|WP_000185863.1\|2776764_2777457_-\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772
NZ_CP022898.1\|WP_115385597.1\|2753184_2754693_-\|accessory-Sec-system-glycosyltransferase-GtfA	unknown	unknown	gnl\|CDD\|131964
NZ_CP022898.1\|WP_000873220.1\|2759585_2761139_-\|accessory-Sec-system-protein-Asp1	unknown	unknown	gnl\|CDD\|274740
NZ_CP022898.1\|WP_000916101.1\|2761149_2762361_-\|accessory-Sec-system-protein-translocase-subunit-SecY2	unknown	unknown	gnl\|CDD\|237095
NZ_CP022898.1\|WP_047213031.1\|2773652_2774012_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_001228567.1\|2772270_2773215_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_000088195.1\|2748970_2749531_-\|cysteine-hydrolase	unknown	unknown	gnl\|CDD\|238245
NZ_CP022898.1\|WP_078157119.1\|2771255_2772209_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022898.1\|WP_001109874.1\|2770249_2770942_-\|flavin-reductase-family-protein	unknown	unknown	gnl\|CDD\|224766
NZ_CP022898.1\|WP_000244266.1\|2775265_2775766_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_000301937.1\|2774786_2775263_-\|peptide-methionine-(S)-S-oxide-reductase	gnl\|CDD\|235497	PRK05528, PRK05528, peptide-methionine (S)-S-oxide reductase.	7.42007e-107
NZ_CP022898.1\|WP_047213026.1\|2754710_2757101_-\|accessory-Sec-system-translocase-SecA2	gnl\|CDD\|163426	TIGR03714, Protein_translocase_subunit_SecA_2, accessory Sec system translocase SecA2. Members of this protein family are homologous to SecA and part of the accessory Sec system. This system, including both five core proteins for export and a variable number of proteins for glycosylation, operates in certain Gram-positive pathogens for the maturation and delivery of serine-rich glycoproteins such as the cell surface glycoprotein GspB in Streptococcus gordonii. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP022898.1\|WP_000556736.1\|2774096_2774708_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	1.60707e-45
NZ_CP022898.1\|WP_115385598.1\|2758027_2759596_-\|accessory-Sec-system-protein-Asp2	gnl\|CDD\|274739	TIGR03712, acc_sec_asp2, accessory Sec system protein Asp2. This protein is designated Asp2 because, along with SecY2, SecA2, and other proteins it is part of the accessory secretory protein system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NZ_CP022898.1\|WP_103225775.1\|2747134_2748702_+\|IS3-like-element-ISSau2-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	6.32114e-44
NZ_CP022898.1\|WP_000593168.1\|2751833_2753192_-\|accessory-Sec-system-glycosylation-chaperone-GtfB	gnl\|CDD\|274351	TIGR02919, conserved_hypothetical_protein, accessory Sec system glycosyltransferase GtfB. Members of this protein family are found only in Gram-positive bacteria of the Firmicutes lineage, including several species of Staphylococcus, Streptococcus, and Lactobacillus. [Protein fate, Protein modification and repair].	0
NZ_CP022898.1\|WP_000916733.1\|2757090_2758050_-\|accessory-Sec-system-protein-Asp3	gnl\|CDD\|163423	TIGR03711, acc_sec_asp3, accessory Sec system protein Asp3. This protein is designated Asp3 because, along with SecY2, SecA2, and other proteins it is part of the accessory Sec system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	6.0984e-65
NZ_CP022898.1\|WP_115385597.1\|2753184_2754693_-\|accessory-Sec-system-glycosyltransferase-GtfA	gnl\|CDD\|131964	TIGR02918, lipopolysaccharide_biosynthesis_protein, accessory Sec system glycosylation protein GtfA. Members of this protein family are found only in Gram-positive bacteria of the Firmicutes lineage, including several species of Staphylococcus, Streptococcus, and Lactobacillus. Members are associated with glycosylation of serine-rich glycoproteins exported by the accessory Sec system. [Protein fate, Protein modification and repair].	0
NZ_CP022898.1\|WP_000873220.1\|2759585_2761139_-\|accessory-Sec-system-protein-Asp1	gnl\|CDD\|274740	TIGR03713, acc_sec_asp1, accessory Sec system protein Asp1. This protein is designated Asp1 because, along with SecY2, SecA2, and other proteins it is part of the accessory secretory protein system. The system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein family is assigned to transport rather than glycosylation function, but the specific molecular role is unknown. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0
NZ_CP022898.1\|WP_000916101.1\|2761149_2762361_-\|accessory-Sec-system-protein-translocase-subunit-SecY2	gnl\|CDD\|237095	PRK12417, secY, preprotein translocase subunit SecY; Reviewed.	1.79345e-177
NZ_CP022898.1\|WP_000185863.1\|2776764_2777457_-\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	2.83977e-84
NZ_CP022898.1\|WP_000565312.1\|2776000_2776768_-\|tyrosine-protein-phosphatase	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.88344e-144
NZ_CP022898.1\|WP_000088195.1\|2748970_2749531_-\|cysteine-hydrolase	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	5.62235e-42
NZ_CP022898.1\|WP_001109874.1\|2770249_2770942_-\|flavin-reductase-family-protein	gnl\|CDD\|224766	COG1853, COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only].	5.94708e-41
NZ_CP022898.1\|WP_000244266.1\|2775265_2775766_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.58707e-14

>NZ_CP022898.1|WP_000916101.1|2761149_2762361_-|accessory-Sec-system-protein-translocase-subunit-SecY2
MLKLLQQYEYKIIYKRILYTCFILFIYILGTNIPIVSYNDMQVKHESFFKIAISNMGGDVNTLNIFTLGLGPWLTSMIILMLISYRNMDKYMKQTSLEKHYKERILTLILSVIQSYFVIHEYVSKERVHQDNIYLTILILVTGTMLLVWLADKNSRYGIAGPMPIVMVSIIKSMMHQKMEYIDASHIVIALLIILVIITLFILLFIELVEVRIPYIDLMNVSATNMKSYLSWKVNPAGSITLMMSISAFVFLKSGIHFILSMFNKDVSDDMPMMTFDSPIGISVYLVIQMLLGYFLSRFLINTKQKSKDFLKSGNYFSEVKPGKDTERYLNYQARRVCWFGSALVTIIIGIPLYFTLFVPHLSTEIYFSVQLIVLVYISINIAETIRTYLYFDKYKPFLNQYW
>NZ_CP022898.1|WP_000873220.1|2759585_2761139_-|accessory-Sec-system-protein-Asp1
MKYFIPAWYDDQRWWQDTTVPYYQTQNKTEFDDMISLMGMHLENNLDYQLIVLNHAPNIRTFLHRYDLYETKYWSVFDEIQGFSHHAPQAINYHHLKWPDDVEFVYTPYLLKCVTSEQTYTNIYFSQEGYSIWFEEFERDQLQRRYIFDDRGYLSAIRYFDDQGEASYQEYLTINGDCVLYENFKNGRVTVSKRYQHHYQQIEYNNMAQLIEEKFQAMIAQQIHEDDHVIVASDARHNRQIANHIPAKLLSYSFFKNRNETVSDEEYQSIVKNAHLIVDSVQLERDLISHQEKYQRENTMIRITPFETRQSPNISSQLMETFIGVWIDGMSDADLQQMMQRLVDYIAQEDNYRLILLTRHQNDIPMWLRECIASVNEEYQAKQNADVNVSALMTPEDQDDIIAVKTIHAEHDVVEALRTLRLVIDMSKEPDLYLQISAISAGIPQINGQQTDYVSDYDNGRIINTVDELDDALNYYLFYLKNWNYAYAYSLKLIDAYASKNIINQLDELIEGENDAT
>NZ_CP022898.1|WP_115385598.1|2758027_2759596_-|accessory-Sec-system-protein-Asp2
MPRKFRVLQIGGDDLEPIFQRKKGVSWDYFDIGLFEFDSGYVEAIEAIVEAEGRFDFIYIQAPYSETLTNLLQMISEPYNTYVDESFWSVEYEQDENVQKYVVQPLHYRNIEERNNKLEAVSFSGQYGDKVSPKLALVHPNFKGDIVYQGNSELTLSGEFGKEFKPIASWQNNLVYDKDKVIQIWPEFDIDGAVELQYTFRLIQTGADGALIEQIILTDDMLDSPLEIPTKPLDAYISVTVKARGNGTVHLGPIHKRWSRLDMGQFLLGGSRFVDSQRQEFIYYFHPGDMKPPLNVYFSGYRTAEGFEGYYMMKRMNAPFLLIGDPRVEGGSFYIGSSEYEQGIINVIDETLEKLNFKSHELILSGLSMGSFGALYYGAQLNPQAIIVGKPLVNIGTIAEHMRLLRPEEFGTALDVLVSNEGDTSQASIQALNQKFWQTFQKKSLSQTVFAIAYMQHDDYDSHAFQELLPVLTAHQARVMNRSIPGRHNDDSPTIASWFVNFYNIILEDKFGRVQHAEKQNI
>NZ_CP022898.1|WP_000916733.1|2757090_2758050_-|accessory-Sec-system-protein-Asp3
MLKNKTFKVTWNYISQTTFMYGSKVSFSNGEVTFINPLMPSGLPIHEWLMLKQFSKYKSAPSLPILRRGQHYKLHFDFDATPAGSVYFIIIFYNKNGTKLSTEIVKSNSITIQYPDEAYAYKIKMMNAASTSLIFRCLTITEMTHQDDLEYKSMRVTKIGDDQYGNDRINVIIAEPSDAYPTISNDFLKPFGHVWLVERWMDDNIEENIKQLKNDLQSQDTLKAINLISYGSKSNVFATYVAQHLDCKVYRTSHEDDDLKDWFKEHVPGNHELKDTNVEVYFKEEQDNHLNYMSRLMNPVRFLDYLDVSKLNGGEVNET
>NZ_CP022898.1|WP_047213026.1|2754710_2757101_-|accessory-Sec-system-translocase-SecA2
MKHKLDVTINELRLKSIRKIVKRINTWSDEVKSYSDDALKQKTIEFKERLVSGVDTLDTLLPEAYAVAREASWRVLGMYPKEVQLIGAIVLHEGNIAEMQTGEGKTLTATMPLYLNALSGKGTYLITTNDYLAKRDFEEMQPLYEWLGLTASLGFVDIVDYEYQKGEKRNIYEHDIIYTTNGRLGFDYLIDNLADSAEGKFLPQLNYGIIDEVDSIILDAAQTPLVISGAPRLQSNLFHIVKEFVDTLIEDVHFKMKKTKKEIWLLNQGIEAAQSYFNVEDLYSEKAMVLVRNINLALRAQYLFESNVDYFVYNGDIVLIDRITGRMLPGTKLQAGLHQAIEAKEGMEVSTDKSVMATITFQNLFKLFGSFSGMTATGKLGESEFFDLYSKIVVQVPTDKAIQRIDEPDKVFRSVDEKNIVMIHDIVELHETGRPVLLITRTAEAAEYFSKVLFQMDIPNNLLIAQNVAKEAQMIAEAGQIGSMTVATSMAGRGTDIKLGEGVEALGGLAVIIHEHMENSRVDRQLRGRSGRQGDPGSSCIYISLDDYLVKRWSDSNLAENNQLYSLDAQRLSQSSLFNRKVKQIVVKAQRISEEQGVKAREMANEFEKSISIQRDLVYEERNRVLEIDDAENRDFKALAKDVFEMFVNEEKVLTKSRVVEYIYQNLSFQFDKDVACVNFKDKQAVVTFLLEQFEKQVALNRKNMQSAYYYNIFVQKVFLKAIDSCWLEQVDYLQQLKASVNQRQNGQRNAIFEYHRVALDSFEVMTRNIKKRMVKNICQSMITFDKEGMPVIHFP
>NZ_CP022898.1|WP_115385597.1|2753184_2754693_-|accessory-Sec-system-glycosyltransferase-GtfA
MTIYNINFGIGWASSGVEYAQAYRAKLLRRTNQDTKFVFLDFIQSENIQTLTQNIGFEDQEVIWLYQYFSDISIAPITYTLDDIERELGHDISFRERNGKIVRLYFNGKSSFVTCYLQNEQKDIVDRAEFVINSMLVRKDFYSYTRIFSEYYAPADNKAKLYMRQFYNEDGSIAYNEYIDGDSSIYVFEDAVLYNKTEFIAYFLQRLNLTRDDIVILDRASDIGQAVLQHKGDSKVGVVIHADHYSNNMMSEQHILWNNYYEYQFSKAKYIDFFITATDIQNHMVCRQFEQYQGYRPRVYTIPVGSIDVLSYPTLSRKPYAMISASRLANEKHIDWLVKAVIVAKRQVPELTFDIYGEGSEKTRLRKIIDTHRAQDYIRLLGHVKLDEIYTDYELFLSASTSEGFGLTLMEAVGSGLGMIGLNVNYGNPTFIRDGENGYLVPFDTDEDSVDDVVAKLAHAIVMYFNNGPQTPHDISYEVAQQFMTQDIILKWETLVQEVLHD
>NZ_CP022898.1|WP_000593168.1|2751833_2753192_-|accessory-Sec-system-glycosylation-chaperone-GtfB
MIKLFDYFNNHSRKLYESFKASKLEEDLTIVLNDNGFLPDDVISPYQFFADNHNSENMKPRFFNQVTVPAFWEIKGNNNSATINDMGRLRGKIFYQSGERPRIVSRVEWFDDQQRVRFVDYYSKNGIKFAQTVYDLNRKAILKKYMTAEGKEVIYENFVTSDVILDWQGKSYFFPSKLAFVLFFIKQLEITEHHFVINSLALPFSVLYNLPSNGSDVLVWQEQCDGNVPGNMQLMCKGDMKRHCNIIIPDKNEYETMLNIADAKVQSRILQGGYLYNYRSRNRYTKEIVILTNSDQLRNIKVLVETLPDFKFYIAAITEMSDKLMQLDQYANVHLYPSINIDRVNELYQLCDIYLDINEGNEILNAVEQAFDYELLILGYRQTAHHAKVTLSEHLFEHNDEITMESKDQLIQMLESLKDQQQFRDALLAQKAHAHEISREQFEQVFKQALES
>NZ_CP022898.1|WP_001151911.1|2749697_2751593_-|cell-wall-anchored-protein-SasF
MAKYRGKPFQLYVKLSCSTMMVTSIILTNILPYDAQAASENDTEISKEILSKQDLLDKVDKANRQIEQLKQLSPSSKAHYKAQLNEAKTASQIDEIIKRANELDSKDNKGSQIEMNGQSDIDSKLDQLLKDLNEVSSKVDRGQQSGEDDLNAMKNDMSQTATTKHGEKDDKNDEAMVDKALEDLDHLNQQIRKSKDTSKDPAVSTTDNNHEVAKTPNNDGSGHVVLNKFLPNEENQSHSNRLTDKLQGSDKINHAMIEKMAKSNASTQHYTYHKLNTLQSLDQRIANTQLPKNQKSDLMSEVNKTKERIKSQRNIILEELARNDDKKYATQSILESIFNKDEADKILKDIRVDGKTDQQIADQITRHIDQLSLTTSDDLLTSLIDQSQDKSLLISQILQTKLGKAEADKLAKDWTNKGLSNRQIVDQLKKHFASTGDTSSDDILKAILNNAKDKKQAIETILATRIERQKAKLLADLITKIETDQNKIFNLVKSALNGKADDLLNLQKRLNQTKKDIDYVLSPIVNRPSLLDRLNKNGKTTDLNKLANLMNQGSNLLDSIPDIPTPKPEKTLTLGKGNGLLSGLLNADGNVSLPKAGETIKEHWLPISVIVGAMGVLMIWLSRRNKLKNKA
>NZ_CP022898.1|WP_000088195.1|2748970_2749531_-|cysteine-hydrolase
MSRKTALLVLDMQEGIASSVPRIKNIIKANQRAIEAARQHRIPVIFIRLVLDKHFNDVSSSNKVFSTIKAQGYAITEADASTRILEDLAPLEDEPIISKRRFSAFTGSYLEVYLRANDINHLVLTGVSTSGAVLSTALESVDKDYYITVLEDAVGDRSDDKHDFIIEQILSRSCDIESVESWKSSL
>NZ_CP022898.1|WP_103225775.1|2747134_2748702_+|IS3-like-element-ISSau2-family-transposase
MKTLKGALFMSIKPKVDIDVLLYMFQEYEKGVSFQYLIDTLQLDINVNTLYPKYKYYKTHGIETLLTQKQYNHYSKELKLKVVNEYLNSNQSTQDLAIKYNIRSSTQVKNWIKMYTVGKEIKNQSPKTGVYIMKARKTTFEERVTIVEYYLNHKQSYREVAEHFNISYGQIYQWVQKYQAHGKNGLVDGRGKGKPKSMMTPEEQKEAEIQALKAQNRLLEMENDVFKKVSSIGKRDDSKRKQITAYKTIEALKHQYPIQRLCRILGISRASYYKWVHYQSSELELENEQLKREIESIYHKYNGIYGYRRIYIYIRLKLGKQVNRKRIYRLMKELNLKAVIRQKRKPYRRSTPQITSENKLNRQFDIDTPNKVWLTDVTEFKIKEGSKIYLSAIYDLGVKRIVSYKLGPSNNNQLVFKTFNQAIEKVENTKGILFHSDRGFQYTSKTFKHMLDECGMIQSMSRVSKCIDNGPMEGVWGTIKSEIFRGNKHFKFNSVEEATKTIHDFILFFNHERITLKMADSV
>NZ_CP022898.1|WP_001109874.1|2770249_2770942_-|flavin-reductase-family-protein
MNYSPKQGVRSHGLPHDPFKSSTVPRPIGWISTVSKDGKDNLAPYSQYQNLTWDPPMVMFAANQSVLGDHERKDTVKNAEETGWFVWNMATYDLREAVNLSSKALPPEEDEFEYAGVTKEACIEAPGYRVKESPVHFECEYVQTIRIPTGDPVSTVDIVIGRVAQVHIDDKVILDNGKLDIKSIKPIARLGYYDYTVVNEIFEMKAPSASKEELAGLEGRNFDNQSDNKK
>NZ_CP022898.1|WP_078157119.1|2771255_2772209_+|hypothetical-protein
MRKIMRILLCTSIIVSGCSFIPKNQTKDIPKTVSVKDYDGQYIGEHKKRNEVFLKKHKDEAIKKYKDYVKDTFGYDCKINLVEAYTNKSGFSEKSKTDGLVVVGTVNYDVPFQFRLIFVESRNGVAITTFTPGHINETSAAVSAMMYKRYEHEIEEARLKFKSEVEKNGYYTMNEKLQKKQEFNGVTKQFLNFNTDSIDDLDKFKKEFKPVMHLKGDAFNQQLQNLINKYPEIKKSMKSDFIAYYDKKSTKNVNKYSWDLQIPTNDTMKKIPGSKMMYFYKDSVSPSEIGEDGRLENKTNKITMSGGNWEEIQKEIK
>NZ_CP022898.1|WP_001228567.1|2772270_2773215_+|hypothetical-protein
MRKLIGFILCTSIIVSGCSFIPKNQTKDIPKTVSVKDYDGQYIGEHKKRNEVFLKKHKDEAIKKYKNYVKDTFGYDCKINLVKPYTNASGFSEKSKTDGLVVVGTVNYDVPFQLRLLFVESDNSVTITTFTPGHENKTSAAISAMMYKRYEHEIEQARLKFKSEVEKNGYFAMNEKLQIKQEYNGVVRQYLNFKTPGIEGMDKFKKEFKPLMNTSNSDFNQKFDALLMKHPEIKDQAKTNFIAYYSKNKTRDIVGDYVVTLQKPTNKVMKNYPGIKFMKFYKDSVSPSQLDKNGRLKPEVEEVSTIGGEYNENK
>NZ_CP022898.1|WP_000856195.1|2773201_2773504_+|hypothetical-protein
MKTNKPITDLDAIELSSAWNYNSKLVTGKNALLSDSLLRDIKVLSSNAKGDADMLETELHAVINAMSQNEGKSVDALKNSTASLKNNLTKLKEQLDKTTH
>NZ_CP022898.1|WP_047213031.1|2773652_2774012_+|hypothetical-protein
MILRYATNLKLAKELYHASKPKLQEDKGMIELFEHTFGLQKELVKYVGIAEATTAALYSASFINKNISRLASLSTIGILSVAAYKHFEAGHGKKGAQHALDLLGLATLSLLDTFSCNKK
>NZ_CP022898.1|WP_000556736.1|2774096_2774708_-|flavin-reductase-family-protein
MHTFDAQSLTARENYKLLIGSIIPRPIAFVTTLNQDASVNAAPFSFFNIVNNHPPMIAIAVQRAGGKRKDTALNIERTGDFVVHITDEDNVQDINETAAPLAYGDSELSRTELSLLTSTTIKTPGIKDAKMRFECKLSQMILIGDVLDGADLIIGEIVTYHIDDSIYEGNFKINPHALQAVSRLAGNDYAKLGGIFTIKRPEK
>NZ_CP022898.1|WP_000301937.1|2774786_2775263_-|peptide-methionine-(S)-S-oxide-reductase
MAVVYVAGGCLWGVEAFFTTIPGIIHTEAGRANGRSSKLDSPYDGYAECVKLHFDDRMLTITDIMNYLFEIIDPYSVNRQGNDIGEKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEVLPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK
>NZ_CP022898.1|WP_000244266.1|2775265_2775766_-|GNAT-family-N-acetyltransferase
MVLRKVIMQDLDQIIALENIGFSPEEAATPEALKLRIEQIQETFIVAEKNDEVIGYINGPVIKERYISDDLFKNVPTNNSEGGYISVLGLVVAPNYQGQGIAGRLLNYFENLAKNQHRHGVTLTCRESLISFYEKYGYRNEGVSESCHGGIKWYNLVKNIKKDDEV
>NZ_CP022898.1|WP_000565312.1|2776000_2776768_-|tyrosine-protein-phosphatase
MIDIHNHILVDIDDGPKTIEKSIALLKQAKDEGVTSIVATPHHLHPRYDNTFQQVLVKLAELRTHPEVQALDIKLFPGQEIRITDSILQGLDNGSIQGINRSKYLLIEFPTGEVPHYTKQLFFEIQSRGYIPIIAHPERNRSIAKNPEILYELVANGALSQLTSSSLVGGFGKNIQKLSLQFIECNLAHFVASDAHSCDQRPFLMQELFHNHKLKKYSNDIEALLRNASSVINDNFVYLDRPTKPGKVKSFLKWF
>NZ_CP022898.1|WP_000185863.1|2776764_2777457_-|polysaccharide-biosynthesis-tyrosine-autokinase
MTNTRRSTSSLIVHEQPKSPISEKFRGIRSNIMFANPDSAVQSIVITSEAPGAGKSTIAANLAVAYAQAGYKTLIVDGDMRKPTQHYIFNLPNNEGLSSLLLNWSTYQDSIISTEIQDLDVLTSGPIPPNPSELITSRAFANLYDTLLMNYNFVIIDTPPVNTVTDAQLFSKFTGNVVYVVNSENNNKDEVKKGKELIEATGAKLLGVVLNRMPKDKSASYYAYYGTDES

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Crispr_ID: NZ_CP022898_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022898_10

2783338-2783416

Orphan

Consensus_repeat	Method
TTCTCTATGTTGGGGCCCCGCCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022898_10

>merge|NZ_CP022898|10|2783338-2783416|CRISPRCasFinder
TTCTCTATGTTGGGGCCCCGCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTTTGTTGGGGCCCCGCCAA

>NZ_CP022898|10|10|2783338-2783416|CRISPRCasFinder
TTCTCTATGTTGGGGCCCCGCCAA	CTCGCATTGCCTGTAGAATTTCTTTTCGAAA
TTCTCTTTGTTGGGGCCCCGCCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022898.1\|WP_000301937.1\|2774786_2775263_-\|peptide-methionine-(S)-S-oxide-reductase	unknown	unknown	gnl\|CDD\|235497
NZ_CP022898.1\|WP_000565312.1\|2776000_2776768_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|226870
NZ_CP022898.1\|WP_000640270.1\|2789737_2790316_-\|imidazoleglycerol-phosphate-dehydratase-HisB	unknown	unknown	gnl\|CDD\|153419
NZ_CP022898.1\|WP_000244266.1\|2775265_2775766_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NZ_CP022898.1\|WP_000723844.1\|2782070_2783123_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|226446
NZ_CP022898.1\|WP_000944131.1\|2792556_2793171_-\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|172153
NZ_CP022898.1\|WP_001065585.1\|2793188_2794007_-\|ATP-phosphoribosyltransferase-regulatory-subunit	unknown	unknown	gnl\|CDD\|237044
NZ_CP022898.1\|WP_000653261.1\|2778983_2779544_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376089
NZ_CP022898.1\|WP_001159430.1\|2779707_2780946_+\|poly-beta-1,6-N-acetyl-D-glucosamine-synthase	unknown	unknown	gnl\|CDD\|274866
NZ_CP022898.1\|WP_000186284.1\|2787081_2787714_-\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	unknown	unknown	gnl\|CDD\|235067
NZ_CP022898.1\|WP_000877364.1\|2781211_2782084_+\|intercellular-adhesin-biosynthesis-polysaccharide-N-deacetylase	unknown	unknown	gnl\|CDD\|188448
NZ_CP022898.1\|WP_000635617.1\|2789162_2789741_-\|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|171871
NZ_CP022898.1\|WP_000659677.1\|2777473_2778136_-\|capsular-polysaccharide-biosynthesis-protein-CapA	unknown	unknown	gnl\|CDD\|226453
NZ_CP022898.1\|WP_000592606.1\|2787710_2788469_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_CP022898.1\|WP_000930656.1\|2791313_2792564_-\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|172308
NZ_CP022898.1\|WP_000185863.1\|2776764_2777457_-\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772
NZ_CP022898.1\|WP_047213039.1\|2790284_2791298_-\|histidinol-phosphate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223157
NZ_CP022898.1\|WP_072358118.1\|2783513_2785556_-\|YSIRK-domain-containing-triacylglycerol-lipase-Lip1	unknown	unknown	gnl\|CDD\|224001
NZ_CP022898.1\|WP_000240580.1\|2780909_2781215_+\|intracellular-adhesion-protein-D	unknown	unknown	gnl\|CDD\|188447
NZ_CP022898.1\|WP_000571733.1\|2788465_2789170_-\|1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase	unknown	unknown	gnl\|CDD\|172156

Protein	Function_ID	Function_description	E-value
NZ_CP022898.1\|WP_000301937.1\|2774786_2775263_-\|peptide-methionine-(S)-S-oxide-reductase	gnl\|CDD\|235497	PRK05528, PRK05528, peptide-methionine (S)-S-oxide reductase.	7.42007e-107
NZ_CP022898.1\|WP_000565312.1\|2776000_2776768_-\|tyrosine-protein-phosphatase	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.88344e-144
NZ_CP022898.1\|WP_000640270.1\|2789737_2790316_-\|imidazoleglycerol-phosphate-dehydratase-HisB	gnl\|CDD\|153419	cd07914, IGPD, Imidazoleglycerol-phosphate dehydratase. Imidazoleglycerol-phosphate dehydratase (IGPD; EC 4.2.1.19) catalyzes the dehydration of imidazole glycerol phosphate to imidazole acetol phosphate, the sixth step of histidine biosynthesis in plants and microorganisms where the histidine is synthesized de novo. There is an internal repeat in the protein domain that is related by pseudo-dyad symmetry, perhaps as a result of an ancient gene duplication. The apo-form of IGPD exists as a catalytically inactive trimer which, in the presence of specific divalent metal cations such as manganese (Mn2+), cobalt (Co2+), cadmium (Cd2+), nickel (Ni2+), iron (Fe2+) and zinc (Zn2+), assembles to form a biologically active high molecular weight metalloenzyme; a 24-mer with 4-3-2 symmetry. Each 24-mer has 24 active sites, and contains around 1.5 metal ions per monomer, each monomer contributing residues to three separate active sites. IGPD enzymes are monofunctional in fungi, plants, archaea and some eubacteria while they are encoded as bifunctional enzymes in other eubacteria, such that the enzyme is fused to histidinol-phosphate phosphatase, the penultimate enzyme of the histidine biosynthesis pathway. The histidine biosynthesis pathway is a potential target for development of herbicides, and IGPD is a target for the triazole phosphonate herbicides.	7.13364e-103
NZ_CP022898.1\|WP_000244266.1\|2775265_2775766_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.58707e-14
NZ_CP022898.1\|WP_000723844.1\|2782070_2783123_+\|acyltransferase-family-protein	gnl\|CDD\|226446	COG3936, COG3936, Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism].	3.49276e-114
NZ_CP022898.1\|WP_000944131.1\|2792556_2793171_-\|ATP-phosphoribosyltransferase	gnl\|CDD\|172153	PRK13584, hisG, ATP phosphoribosyltransferase.	2.8628e-131
NZ_CP022898.1\|WP_001065585.1\|2793188_2794007_-\|ATP-phosphoribosyltransferase-regulatory-subunit	gnl\|CDD\|237044	PRK12294, hisZ, ATP phosphoribosyltransferase regulatory subunit; Provisional.	1.26228e-173
NZ_CP022898.1\|WP_000653261.1\|2778983_2779544_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|376089	pfam18665, TetR_C_37, Tetracyclin repressor-like, C-terminal domain. IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.	2.88245e-28
NZ_CP022898.1\|WP_001159430.1\|2779707_2780946_+\|poly-beta-1,6-N-acetyl-D-glucosamine-synthase	gnl\|CDD\|274866	TIGR03937, Poly-beta-16-N-acetyl-D-glucosamine_synthase, poly-beta-1,6 N-acetyl-D-glucosamine synthase. Members of this protein family are biofilm-forming enzymes that polymerize N-acetyl-D-glucosamine residues in beta(1,6) linkage. One named members is IcaA (intercellular adhesin protein A), an enzyme that acts (with aid of subunit IcaD) in Polysaccharide Intercellular Adhesin (PIA) biosynthesis in Staphylococcus epidermis). The homologous member in E. coli is designated PgaC. Members are often encoded next to a polysaccharide deacetylase and involved in biofilm formation. Note that chitin, although also made from N-acetylglucosamine, is formed with beta-1,4 linkages.	0
NZ_CP022898.1\|WP_000186284.1\|2787081_2787714_-\|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE	gnl\|CDD\|235067	PRK02759, PRK02759, bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE.	1.51084e-110
NZ_CP022898.1\|WP_000877364.1\|2781211_2782084_+\|intercellular-adhesin-biosynthesis-polysaccharide-N-deacetylase	gnl\|CDD\|188448	TIGR03933, Poly-beta-16-N-acetyl-D-glucosamine_N-deacetylase, intercellular adhesin biosynthesis polysaccharide N-deacetylase. A common motif in bacterial biosynthesis of polysaccharide for export is modification that follows polymerization. This model describes a subfamily of polysaccharide N-deacetylases that acts on poly-beta-1,6-N-acetyl-D-glyscosamine as produced by Staphylococcus epidermidis and S. aureus. The end product in these species is designated polysaccharide intercellular adhesin (PIA), and this gene designated icaB (intercellular adhesion protein B). [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Cellular processes, Pathogenesis].	6.15216e-151
NZ_CP022898.1\|WP_000635617.1\|2789162_2789741_-\|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|171871	PRK13142, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	9.73797e-130
NZ_CP022898.1\|WP_000659677.1\|2777473_2778136_-\|capsular-polysaccharide-biosynthesis-protein-CapA	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	1.17617e-89
NZ_CP022898.1\|WP_000592606.1\|2787710_2788469_-\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	1.14549e-155
NZ_CP022898.1\|WP_000930656.1\|2791313_2792564_-\|histidinol-dehydrogenase	gnl\|CDD\|172308	PRK13770, PRK13770, histidinol dehydrogenase; Provisional.	0
NZ_CP022898.1\|WP_000185863.1\|2776764_2777457_-\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	2.83977e-84
NZ_CP022898.1\|WP_047213039.1\|2790284_2791298_-\|histidinol-phosphate-aminotransferase-family-protein	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	1.50634e-79
NZ_CP022898.1\|WP_072358118.1\|2783513_2785556_-\|YSIRK-domain-containing-triacylglycerol-lipase-Lip1	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	8.21827e-82
NZ_CP022898.1\|WP_000240580.1\|2780909_2781215_+\|intracellular-adhesion-protein-D	gnl\|CDD\|188447	TIGR03932, IcaD_partial, intracellular adhesion protein D. Members of this protein family are IcaD (intracellular adhesion protein D), which with catalytic subunit IcaA forms an N-acetylglucosaminyltransferase. In the absence of IcaC, this enzyme forms N-acetylglucosamine oligomers up to 20 in length. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	3.14464e-30
NZ_CP022898.1\|WP_000571733.1\|2788465_2789170_-\|1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase	gnl\|CDD\|172156	PRK13587, PRK13587, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Provisional.	6.30354e-168

>NZ_CP022898.1|WP_000723844.1|2782070_2783123_+|acyltransferase-family-protein
MKKIRLELVYLRAIICAIIIVTHLLTQITLKHENMEGGSLVLQFYIRNIVIFGTPCFIILSQLLTTLNYQKVTYRYLTTRVKYILIPYILMGLFYSYSESLLTDTSFQKQFIENVLLGQWYGYFIVVIMQFFILSYIIFKINYNLFNSKILLLLSFILQQSFLYYFTNNTAFHDTVLHYYPLSENTIIFGWIFYFFLGAYMGYNYERVLNFLERYLVIMIVLAVATYFVFIALANGDYWNVTSFSYSLTPYNSIMFIVILGICTHFKTMLFNTIQMISAFSFFIYLLHPIILDSLFAYTNIFEDNTMVFLAISLLFILGLCIGVGMILREFYIFRFIIGKQPYKLNINAY
>NZ_CP022898.1|WP_000877364.1|2781211_2782084_+|intercellular-adhesin-biosynthesis-polysaccharide-N-deacetylase
MKYRKLIILVLSILIILPVSTLDGHHIANADDDPPKKLKYKENSALALNYHRVRKANFLNNFIYFFSSSKEIKNYSVSQSQFESQIKWLKSHDAKFLTLKEFLYYKKKGKFPKRSVWINFDDMDETIYENAYPILKKYKIPATGFIITGHVGEENFHNLDMISKKELKEMYKTGLWEFETHTHDLHNLSKNNKSKLMKSSEATIIKDLNKSEKYLTKNFKKSQKTIAYPYGLMNDDKLPVIKKAGLKYGFSLEEKAVTPNSNDYYIPRILISDDAFEHLIKRWDGFHEKD
>NZ_CP022898.1|WP_000240580.1|2780909_2781215_+|intracellular-adhesion-protein-D
MVKPRQREYPTLKSSLNIVRETALIAISCVFWIYCLVVLLVYIGTIFEIHDESINTIRVALNIENTEILDIFETMGIFAIIIFVFFTISILIQKWQRGRES
>NZ_CP022898.1|WP_001159430.1|2779707_2780946_+|poly-beta-1,6-N-acetyl-D-glucosamine-synthase
MQFFNFLLFYPVFMSIYWIVGSIYFYFTREIRYSLNKKPDINVDELEGITFLLACYNESETIEDTLSNVLALKYEKKEIIIINDGSSDNTAELIYKIKENNDFIFVDLQENRGKANALNQGIKQASYDYVMCLDADTIVDQDAPYYMIENFKHDPKLGAVTGNPRIRNKSSILGKIQTIEYASLIGCIKRSQTLAGAVNTISGVFTLFKKSAVVDVGYWDTDMITEDIAVSWKLHLRGYRIKYEPLAMCWMLVPETLGGLWKQRVRWAQGGHEVLLRDFFSTMKTKRFPLYILMFEQIISILWVYIVLLYLGYLFITANFLDYTFMTYSFSIFLLSSFTMTFINVIQFTVALFIDSRYEKKNMAGLIFVSWYPTVYWIINAAVVLVAFPKALKRKKGGYATWSSPDRGNTQR
>NZ_CP022898.1|WP_000653261.1|2778983_2779544_-|TetR/AcrR-family-transcriptional-regulator
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQFLFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNIFLKK
>NZ_CP022898.1|WP_000659677.1|2777473_2778136_-|capsular-polysaccharide-biosynthesis-protein-CapA
MKEKFDLVKLLNILKKNIKLLLILPAICLVVSAALTFFVMPDKYTASTQILVNMKKSSSDLAFQNVQSSLQSVNTYTEIIKSPRILDKVSREFDGQYSTAELNSFLKVTNQTNSQIITVSVTTGNKSESDKIVNRISKVFAHDMPKIMSVDNVTILSSAHDNAVKVSPIVSVNLVISIIVGIVLAILIIFLKELLDKRIKTEEDVESQLGLPILGSIQKF
>NZ_CP022898.1|WP_000185863.1|2776764_2777457_-|polysaccharide-biosynthesis-tyrosine-autokinase
MTNTRRSTSSLIVHEQPKSPISEKFRGIRSNIMFANPDSAVQSIVITSEAPGAGKSTIAANLAVAYAQAGYKTLIVDGDMRKPTQHYIFNLPNNEGLSSLLLNWSTYQDSIISTEIQDLDVLTSGPIPPNPSELITSRAFANLYDTLLMNYNFVIIDTPPVNTVTDAQLFSKFTGNVVYVVNSENNNKDEVKKGKELIEATGAKLLGVVLNRMPKDKSASYYAYYGTDES
>NZ_CP022898.1|WP_000565312.1|2776000_2776768_-|tyrosine-protein-phosphatase
MIDIHNHILVDIDDGPKTIEKSIALLKQAKDEGVTSIVATPHHLHPRYDNTFQQVLVKLAELRTHPEVQALDIKLFPGQEIRITDSILQGLDNGSIQGINRSKYLLIEFPTGEVPHYTKQLFFEIQSRGYIPIIAHPERNRSIAKNPEILYELVANGALSQLTSSSLVGGFGKNIQKLSLQFIECNLAHFVASDAHSCDQRPFLMQELFHNHKLKKYSNDIEALLRNASSVINDNFVYLDRPTKPGKVKSFLKWF
>NZ_CP022898.1|WP_000244266.1|2775265_2775766_-|GNAT-family-N-acetyltransferase
MVLRKVIMQDLDQIIALENIGFSPEEAATPEALKLRIEQIQETFIVAEKNDEVIGYINGPVIKERYISDDLFKNVPTNNSEGGYISVLGLVVAPNYQGQGIAGRLLNYFENLAKNQHRHGVTLTCRESLISFYEKYGYRNEGVSESCHGGIKWYNLVKNIKKDDEV
>NZ_CP022898.1|WP_000301937.1|2774786_2775263_-|peptide-methionine-(S)-S-oxide-reductase
MAVVYVAGGCLWGVEAFFTTIPGIIHTEAGRANGRSSKLDSPYDGYAECVKLHFDDRMLTITDIMNYLFEIIDPYSVNRQGNDIGEKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEVLPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK
>NZ_CP022898.1|WP_072358118.1|2783513_2785556_-|YSIRK-domain-containing-triacylglycerol-lipase-Lip1
MKSQNKYSIRKFSVGASSILIATLLFLSGGQAQAAEKQVNMGNSQEDTVTAQSIGDQQTRENANYQRENGVDEQQHTENLTKNLHNDKTISEENHRKTDDLNKDQLKDDKKSSLNNKNIQRDTTKNNNANPSDVNQGLEQAINDGKQSKVASQQQSKETDNSQDSNANNNLPSQSRTKEALPLNKSNQTSQREIVNKTEIEKVQPQQNNQANDKITNYNFNNEKEVKPQKDEKTLSVSDLKNNQKSPVEPTKDNDKKNGLNLLKSSAVATLPNKGTKELTAKAKGDQTNKVAKQGQYKNQDPIVLVHGFNGFTDDINPSVLAHYWGGNKMNIRQDLEENGYKAYEASISAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYEGIYKDWKPGQKVHLVGHSMGGQTIRQLEELLRNGNREEIEYQKKHGGEISPLFKGNNDNMISSITTLGTPHNGTHASDLAGNEALVRQIVFDIGKMFGNKNSRVDFGLAQWGLKQKPNESYIDYVKRVKQSNLWKSKDNGFYDLTREGATDLNRKTSLNPNIVYKTYTGEATHKALNSDRQKADLNMFFPFVITGNLIGKATEKEWRENDGLVSVISSQHPFNQAYTNATDKIQKGIWQVTPTKHDWDHVDFVGQDSSDTVRTREELQDFWHHLADDLVKTEKVTDTKQA
>NZ_CP022898.1|WP_000186284.1|2787081_2787714_-|bifunctional-phosphoribosyl-AMP-cyclohydrolase/phosphoribosyl-ATP-diphosphatase-HisIE
MTNYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTILIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW
>NZ_CP022898.1|WP_000592606.1|2787710_2788469_-|imidazole-glycerol-phosphate-synthase-subunit-HisF
MIKKRIIPCLDVKDGRVVKGIQFKGLRDIGNPVDLAMYYNEAGADELVFLDISKTEEGHSLMLEVIEQTASRLFIPLTVGGGIQSLDDITQLLNHGADKVSLNSSALKNPQLIKQASDKFGRQCICIAIDSYYDPERKAHYCCTHGGKKMTNIKVYDWVQQVEQLGAGELLVTSMGHDGMKQGFDIEHLAKIKSLVNIPIIASGGSGNAQHFVELFNQTDVSAGLAASILHDRETTVQSIKEVIRQGGIAVR
>NZ_CP022898.1|WP_000571733.1|2788465_2789170_-|1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVKQLSDIPLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK
>NZ_CP022898.1|WP_000635617.1|2789162_2789741_-|imidazole-glycerol-phosphate-synthase-subunit-HisH
MIVIVDYGLGNISNVKRAIEHLGYEVVVSNNPKIIDQAETIILPGVGHFKDAMSEIKRLNLDAILAKNTDKKMIGICLGMQLMYEHSDEGDASGLGFIPGNISRIQTEYPVPHLGWNNLVSKHPMLNQDVYFVHSYQAPMSENVIAYAQYGTDIPAIVQFNNYIGIQFHPEKSGTYGLQILRQAIQGGFIND
>NZ_CP022898.1|WP_000640270.1|2789737_2790316_-|imidazoleglycerol-phosphate-dehydratase-HisB
MIYQKQRNTAETQLNISISDDQSPSHINTGVGFLNHMLTLFTFHSGLSLNIEAQGDIDVDDHHVTEDIGIVIGQLLLEMIKDKKHFVRYGTMYIPMDETLARVVVDISGRPYLSFNATLSKEKVGTFDTELVEEFFRAVVINARLTTHIDLIRGGNTHHEIEAIFKAFSRALGIALTATDDQRVPSSKGVIE
>NZ_CP022898.1|WP_047213039.1|2790284_2791298_-|histidinol-phosphate-aminotransferase-family-protein
MIYIDKNESPVTPLDEKTMTSIISATPYNLYPDAAYEQFKDAYAKFYGLSSEQIIAGNGSDELIQKLMLIMPEGLALTLNPDFFMYQAYAAQVNREIAFVDAGSDLTFDLETILTKIDEVQPSFFIMSNPHNPSGKQFDTAFLTAIADKMKAINGYFVIDEAYLDYGMAYDVELAPHILRMRTLSKAFGIAGLRLGVLISTAETIQRIQTIEHPYPLNVFTLNIATYIFRHREETSRFLTMQRQLANQLKQIFDTHVADKMSVFPSNANFVLTKGSAAQQLGQYVYEQGFKPRFYDEQVMKGYVRYSIATASQLKQLEEIVKEWSTKYDLSKTTKHS
>NZ_CP022898.1|WP_000930656.1|2791313_2792564_-|histidinol-dehydrogenase
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIVYDVFAQAEHDELARTYVISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACYVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFDQIADSAQHIAHVEALYNHQQSILIRQS
>NZ_CP022898.1|WP_000944131.1|2792556_2793171_-|ATP-phosphoribosyltransferase
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGIADIGIVGSDILDERHYNVNNLLDMPFGACHFAVAAKPETTKYHKIATSYVHTAEAYFKSKGIDVELIKLSGSVELACVVDMVDGIVDIVQTGTTLEANGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA
>NZ_CP022898.1|WP_001065585.1|2793188_2794007_-|ATP-phosphoribosyltransferase-regulatory-subunit
MNNSEQLIALKESETAFLKYFNKADYELVDFSVVEKLDWKQLNHEDLQQMGERNFWQHEHQIYALRNDFTDQLLRYYSMYPTAATKVAYTGLIIRNNEAAVQVGLENYAPSLANVQQSLKLFIQFIQQQLRDKVHFVVLGHYQLLDALLDKSLQTPDILSMIEERNLSGLVTYLSTEHPIVQILKENTQQQLNVLEHYIPNDHPALVELKIWERWLHTQGYNDIHLDITAQPPRSYYTGLFIQCHFAENESRVLTGGYYKGSIEGFGLGLTL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	768403-768436	0	1.0
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	812720-812753	0	1.0
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	1023994-1024024	0	1.0
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	1648132-1648162	0	1.0
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	1648190-1648220	0	1.0
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	2818138-2818168	0	1.0
NZ_CP022898_1	1.1\|481036\|28\|NZ_CP022898\|CRISPRCasFinder	481036-481063	28	NZ_CP022898.1	596446-596473	1	0.964
NZ_CP022898_1	1.1\|481036\|28\|NZ_CP022898\|CRISPRCasFinder	481036-481063	28	NZ_CP022898.1	768280-768307	1	0.964
NZ_CP022898_1	1.1\|481036\|28\|NZ_CP022898\|CRISPRCasFinder	481036-481063	28	NZ_CP022898.1	1977519-1977546	1	0.964
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	329448-329481	1	0.971
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	329503-329536	1	0.971
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	722310-722343	1	0.971
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	1125825-1125858	1	0.971
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	236701-236731	1	0.968
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	596387-596417	1	0.968
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	768393-768423	1	0.968
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	926089-926119	1	0.968
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	1053727-1053757	1	0.968
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	1682272-1682302	1	0.968
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	1977462-1977492	1	0.968
NZ_CP022898_1	1.1\|481036\|28\|NZ_CP022898\|CRISPRCasFinder	481036-481063	28	NZ_CP022898.1	1217265-1217292	2	0.929
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	816887-816920	2	0.941
NZ_CP022898_4	4.1\|2083817\|34\|NZ_CP022898\|CRISPRCasFinder	2083817-2083850	34	NZ_CP022898.1	1382853-1382886	2	0.941
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	329406-329436	2	0.935
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	481149-481179	2	0.935
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	481207-481237	2	0.935
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	777377-777407	2	0.935
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	816797-816827	2	0.935
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP022898.1	1770445-1770475	2	0.935

1. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 768403-768436, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

2. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 812720-812753, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

3. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 1023994-1024024, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

4. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 1648132-1648162, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

5. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 1648190-1648220, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

6. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 2818138-2818168, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

7. spacer 1.1|481036|28|NZ_CP022898|CRISPRCasFinder matches to position: 596446-596473, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

8. spacer 1.1|481036|28|NZ_CP022898|CRISPRCasFinder matches to position: 768280-768307, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

9. spacer 1.1|481036|28|NZ_CP022898|CRISPRCasFinder matches to position: 1977519-1977546, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

10. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 329448-329481, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

11. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 329503-329536, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctatgttgg	Protospacer
***************************.******

12. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 722310-722343, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

13. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 1125825-1125858, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattatctgtgttgg	Protospacer
*********************** **********

14. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 236701-236731, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

15. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 596387-596417, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

16. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 768393-768423, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcttgtagaatttcttttcgaaa	Protospacer
**********.********************

17. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 926089-926119, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

18. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 1053727-1053757, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattacctgtagaatttcttttcgaaa	Protospacer
********.**********************

19. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 1682272-1682302, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttctttacgaaa	Protospacer
************************* *****

20. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 1977462-1977492, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

21. spacer 1.1|481036|28|NZ_CP022898|CRISPRCasFinder matches to position: 1217265-1217292, mismatch: 2, identity: 0.929

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacaataatgtgca	Protospacer
*****************.**** *****

22. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 816887-816920, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaatcctctatgttgg	Protospacer
**********************.****.******

23. spacer 4.1|2083817|34|NZ_CP022898|CRISPRCasFinder matches to position: 1382853-1382886, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtgggatttcttttcgaaattctctgtgttgg	Protospacer
****.*.***************************

24. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 329406-329436, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaattccttttcgaaa	Protospacer
**.*****************.**********

25. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 481149-481179, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

26. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 481207-481237, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

27. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 777377-777407, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcatttcgaaa	Protospacer
**.******************* ********

28. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 816797-816827, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcactgcctgtagaatttctttttgaaa	Protospacer
******.*******************.****

29. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to position: 1770445-1770475, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022898_1	1.1\|481036\|28\|NZ_CP022898\|CRISPRCasFinder	481036-481063	28	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159754-159781	5	0.821
NZ_CP022898_7	7.1\|2394111\|26\|NZ_CP022898\|CRISPRCasFinder	2394111-2394136	26	MN545971	Citrobacter virus HCF1, complete genome	42896-42921	5	0.808
NZ_CP022898_1	1.1\|481036\|28\|NZ_CP022898\|CRISPRCasFinder	481036-481063	28	LN846932	Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome	10627-10654	6	0.786
NZ_CP022898_2	2.1\|1041971\|29\|NZ_CP022898\|CRISPRCasFinder	1041971-1041999	29	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	703321-703349	6	0.793
NZ_CP022898_1	1.1\|481036\|28\|NZ_CP022898\|CRISPRCasFinder	481036-481063	28	NZ_CP015319	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a	9464-9491	7	0.75
NZ_CP022898_10	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP009619	Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence	270870-270900	8	0.742

1. spacer 1.1|481036|28|NZ_CP022898|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 5, identity: 0.821

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaactcaccttacgataaaattta	Protospacer
******* *** ***********.* .*

2. spacer 7.1|2394111|26|NZ_CP022898|CRISPRCasFinder matches to MN545971 (Citrobacter virus HCF1, complete genome) position: , mismatch: 5, identity: 0.808

gtagtcaactgtataccttttgcctt	CRISPR spacer
gtagtcaaccgtataacttttgcgcg	Protospacer
*********.***** ******* .

3. spacer 1.1|481036|28|NZ_CP022898|CRISPRCasFinder matches to LN846932 (Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome) position: , mismatch: 6, identity: 0.786

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaaatcagattacgataaattagt	Protospacer
*******.**** ********** *.

4. spacer 2.1|1041971|29|NZ_CP022898|CRISPRCasFinder matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 6, identity: 0.793

taaaagagggatacttgcgctgagcgcat	CRISPR spacer
gatcaaagggttccttgcgctgagcgcat	Protospacer
 *  *.**** * ****************

5. spacer 1.1|481036|28|NZ_CP022898|CRISPRCasFinder matches to NZ_CP015319 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a) position: , mismatch: 7, identity: 0.75

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
tcgaaatgtcagcttacgaaaaagcttt	Protospacer
 ***** ************ ****. .

6. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to NZ_CP009619 (Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence) position: , mismatch: 8, identity: 0.742

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
gctgcattacctgtagcatttcttttttcaa	Protospacer
 ..*****.******* *********.  **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

700704 : 708524

Hokovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|700704_701760_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|701759_702446_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037811.1\|702420_702894_-	DoxX family protein	NA	NA	NA	NA
WP_001093557.1\|703235_703676_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637683.1\|703955_704540_-	hypothetical protein	NA	NA	NA	NA
WP_001062968.1\|704638_705352_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941334.1\|705355_705775_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446721.1\|705776_706445_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.1
WP_000604509.1\|706795_707389_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.5e-38	44.0
WP_001217797.1\|707372_708524_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_2

720496 : 734689

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663031.1\|720496_721555_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.3e-21	26.4
WP_000197262.1\|721712_722255_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429016.1\|722860_723778_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.4
WP_000193751.1\|724059_725565_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930020.1\|725904_726405_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.2e-51	70.8
WP_001068497.1\|726424_727291_-	DMT family transporter	NA	NA	NA	NA
WP_000692523.1\|728091_728490_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	4.3e-53	72.7
WP_000855505.1\|728452_730558_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|730675_731647_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499194.1\|731822_731978_+	hypothetical protein	NA	NA	NA	NA
WP_047213721.1\|732016_732985_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	8.0e-138	79.1
WP_001245577.1\|732974_733931_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616870.1\|733927_734689_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.0e-18	31.6

DBSCAN-SWA_3

821132 : 868713

Staphylococcus_virus(49.23%)

plate,portal,head,integrase,capsid,holin,transposase,terminase

attL 812772:812787|attR 826257:826272

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
812772:812787	attL	NA	NA	NA	NA
WP_001006454.1\|821132_822383_+	cysteine desulfurase	Q2XUY6	environmental_halophage	1.4e-110	44.5
WP_001010508.1\|822372_822837_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
WP_001074405.1\|822988_824386_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
WP_015967223.1\|824453_825503_-\|integrase	site-specific integrase	Q9G044	Staphylococcus_virus	2.0e-203	100.0
WP_015967224.1\|825560_825932_-	hypothetical protein	Q9G043	Staphylococcus_virus	4.1e-34	100.0
WP_015967225.1\|825921_826347_-	hypothetical protein	Q9G042	Staphylococcus_virus	6.1e-74	100.0
826257:826272	attR	NA	NA	NA	NA
WP_015967226.1\|826402_826588_-	hypothetical protein	Q9G041	Staphylococcus_virus	3.0e-25	100.0
WP_015967227.1\|826742_827459_-	helix-turn-helix domain-containing protein	Q9G039	Staphylococcus_virus	9.2e-131	100.0
WP_000639927.1\|827622_827865_+	DUF739 family protein	Q9G038	Staphylococcus_virus	2.8e-39	100.0
WP_000393082.1\|827880_828060_+	hypothetical protein	A0A0H3U490	Staphylococcus_phage	4.4e-26	100.0
WP_000394410.1\|828160_828643_-	hypothetical protein	A0A0N9BAX2	Staphylococcus_phage	1.1e-82	100.0
WP_000933365.1\|829087_829273_+	helix-turn-helix transcriptional regulator	A0A0H4IP57	Staphylococcus_phage	1.3e-25	100.0
WP_015967228.1\|829274_830027_+	hypothetical protein	Q9G034	Staphylococcus_virus	9.6e-139	100.0
WP_015967229.1\|830131_830797_-	hypothetical protein	Q9G033	Staphylococcus_virus	1.3e-118	100.0
WP_000594792.1\|830867_831089_+	hypothetical protein	A0A0H4ISQ0	Staphylococcus_phage	1.5e-31	100.0
WP_000048124.1\|831081_831243_+	DUF1270 family protein	C7F7L3	Staphylococcus_phage	1.9e-20	100.0
WP_015967230.1\|831336_831597_+	DUF1108 family protein	C7F7L4	Staphylococcus_phage	1.5e-43	100.0
WP_001077280.1\|831606_831828_+	DUF2483 family protein	A0A0E3TAJ7	Staphylococcus_phage	2.4e-34	100.0
WP_106459734.1\|831820_832600_+	ATP-binding protein	Q9G028	Staphylococcus_virus	1.3e-141	99.6
WP_015978330.1\|832628_833180_+	hypothetical protein	A0A0H4IPV5	Staphylococcus_phage	3.4e-101	100.0
WP_047213271.1\|833192_833858_+	hypothetical protein	Q4ZDQ9	Staphylococcus_virus	1.7e-126	99.5
WP_154423117.1\|833859_834189_+	hypothetical protein	Q4ZDQ8	Staphylococcus_virus	3.9e-52	98.2
WP_001566734.1\|834516_835287_+	hypothetical protein	A0A0H4IPD8	Staphylococcus_phage	8.4e-122	100.0
WP_000803063.1\|835296_836076_+	ATP-binding protein	A0A068A1Z4	Staphylococcus_phage	2.9e-146	100.0
WP_000256594.1\|836069_836228_+	hypothetical protein	A0A2I6PDX0	Staphylococcus_phage	4.5e-22	98.1
WP_001123681.1\|836241_836463_+	DUF3269 family protein	A0A2H4PQI9	Staphylococcus_phage	2.2e-35	100.0
WP_029549553.1\|836472_836880_+	RusA family crossover junction endodeoxyribonuclease	A9CR74	Staphylococcus_phage	8.4e-73	98.5
WP_029549552.1\|836879_837065_+	DUF3113 family protein	M9NSS9	Staphylococcus_phage	7.0e-27	98.4
WP_015967239.1\|837328_837499_+	hypothetical protein	Q9G017	Staphylococcus_virus	1.0e-24	100.0
WP_001566727.1\|837925_838078_+	DUF1024 family protein	Q9G015	Staphylococcus_virus	3.3e-22	100.0
WP_015967241.1\|838074_838359_+	hypothetical protein	Q9G014	Staphylococcus_virus	3.6e-46	100.0
WP_015967242.1\|838351_838594_+	DUF1024 family protein	Q9G013	Staphylococcus_virus	1.3e-36	100.0
WP_015967243.1\|838593_838836_+	hypothetical protein	Q9G012	Staphylococcus_virus	1.4e-35	100.0
WP_015967244.1\|838828_839365_+	hypothetical protein	Q9G011	Staphylococcus_virus	4.2e-96	100.0
WP_000195803.1\|839401_839608_+	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000592207.1\|839604_839991_+	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000595257.1\|839987_840161_+	transcriptional activator RinB	Q4ZBK0	Staphylococcus_phage	6.4e-22	100.0
WP_000286968.1\|840161_840563_+	hypothetical protein	A0A2H4PQK5	Staphylococcus_phage	5.6e-69	100.0
WP_000594085.1\|840914_841409_+	hypothetical protein	A0A0H4J343	Staphylococcus_phage	8.4e-83	100.0
WP_001807202.1\|841401_842610_+\|terminase	PBSX family phage terminase large subunit	A0A0H4ITX6	Staphylococcus_phage	1.0e-235	100.0
WP_001159669.1\|842563_844042_+\|portal	phage portal protein	Q4ZB45	Staphylococcus_virus	4.3e-284	99.6
WP_047213283.1\|843980_844961_+\|capsid	minor capsid protein	A0A0E3XC69	Staphylococcus_phage	5.9e-181	99.1
WP_015967248.1\|845058_845655_+	hypothetical protein	C7F7L8	Staphylococcus_phage	3.4e-78	100.0
WP_015967249.1\|845675_846500_+\|capsid	N4-gp56 family major capsid protein	Q9G001	Staphylococcus_virus	1.2e-147	100.0
WP_015967250.1\|846516_846843_+	hypothetical protein	Q9G000	Staphylococcus_virus	3.3e-51	100.0
WP_015967251.1\|846842_847157_+	hypothetical protein	Q9FZZ9	Staphylococcus_virus	3.4e-53	100.0
WP_015967252.1\|847149_847485_+\|head	phage head closure protein	Q9FZZ8	Staphylococcus_virus	2.3e-60	100.0
WP_001151332.1\|847471_847885_+	HK97 gp10 family phage protein	A0A0E3XCY8	Staphylococcus_phage	1.5e-77	100.0
WP_015967254.1\|847897_848335_+	DUF3168 domain-containing protein	A0A2H4PQL6	Staphylococcus_phage	1.6e-77	100.0
WP_000046067.1\|848321_848882_+	hypothetical protein	A0A0H4ITY2	Staphylococcus_phage	5.9e-101	100.0
WP_000141084.1\|848943_849438_+	hypothetical protein	A0A0H4IPX9	Staphylococcus_phage	2.5e-87	100.0
WP_000204079.1\|849458_849800_+	hypothetical protein	W5R8J4	Staphylococcus_phage	3.5e-56	100.0
WP_015967255.1\|849802_852772_+	hypothetical protein	Q9FZZ2	Staphylococcus_virus	6.5e-263	100.0
WP_015967256.1\|852786_853722_+	hypothetical protein	Q9FZZ1	Staphylococcus_virus	4.8e-180	100.0
WP_015967257.1\|853732_855619_+	hypothetical protein	Q9FZZ0	Staphylococcus_virus	0.0e+00	100.0
WP_015967258.1\|855631_857530_+	hypothetical protein	Q9FZY9	Staphylococcus_virus	0.0e+00	100.0
WP_015967259.1\|857529_859353_+\|plate	BppU family phage baseplate upper protein	Q9FZY8	Staphylococcus_virus	4.6e-296	100.0
WP_000705910.1\|859352_859730_+	DUF2977 domain-containing protein	Q9FZY7	Staphylococcus_virus	1.2e-60	100.0
WP_000782200.1\|859733_859907_+	XkdX family protein	A0A0F6N3L7	Staphylococcus_phage	6.6e-27	100.0
WP_000466784.1\|859947_860247_+	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_015967260.1\|860383_862258_+	CHAP domain-containing protein	Q9FZY4	Staphylococcus_virus	0.0e+00	100.0
WP_047213289.1\|862270_863509_+\|plate	BppU family phage baseplate upper protein	Q9FZY3	Staphylococcus_virus	7.7e-210	99.8
WP_001576757.1\|863514_863910_+	hypothetical protein	Q9FZY2	Staphylococcus_virus	1.6e-68	100.0
WP_000351119.1\|863966_864242_+\|holin	phage holin	A0A0F6N3M0	Staphylococcus_phage	8.6e-45	100.0
WP_015967262.1\|864228_865641_+	CHAP domain-containing protein	Q9FZY0	Staphylococcus_virus	2.0e-286	100.0
WP_001065781.1\|865766_866609_+	exfoliative toxin A	A0A0E3T8P7	Staphylococcus_phage	2.3e-157	100.0
WP_115385526.1\|867145_868713_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.7e-49	51.4

DBSCAN-SWA_4

979088 : 1025734

Staphylococcus_phage(33.33%)

transposase,protease,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_072357901.1\|979088_981413_+\|protease	serine protease	W5SAB9	Pithovirus	2.1e-11	27.4
WP_000021872.1\|981429_982788_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_115385531.1\|982973_984437_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|984923_985493_-	competence protein ComK	NA	NA	NA	NA
WP_000876826.1\|985702_985921_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668813.1\|986001_986988_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|987186_987363_+	YkvS family protein	NA	NA	NA	NA
WP_001033867.1\|987377_987980_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_029693138.1\|989006_989273_+\|bacteriocin	bacteriocin transporter	NA	NA	NA	NA
WP_000870824.1\|989316_991281_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000668628.1\|991283_991604_+	YxeA family protein	NA	NA	NA	NA
WP_000571186.1\|991600_992242_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-19	33.7
WP_072357895.1\|992329_992620_-	hypothetical protein	NA	NA	NA	NA
WP_000415394.1\|992961_993249_+	hypothetical protein	NA	NA	NA	NA
WP_115385532.1\|993254_994736_+	glycosyltransferase	NA	NA	NA	NA
WP_000766009.1\|994824_995181_-	DoxX family protein	NA	NA	NA	NA
WP_001081355.1\|995667_996627_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020978112.1\|996672_996804_-	hypothetical protein	NA	NA	NA	NA
WP_001788574.1\|996867_997158_-	TM2 domain-containing protein	A0A060AN66	Enterococcus_phage	7.5e-07	38.0
WP_000620941.1\|997247_997799_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000070966.1\|997849_998788_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_078103419.1\|998938_999016_+	hypothetical protein	NA	NA	NA	NA
WP_078103418.1\|999119_1000331_+	isochorismate synthase	NA	NA	NA	NA
WP_000526675.1\|1000317_1001991_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
WP_000150207.1\|1001977_1002781_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
WP_000184945.1\|1002773_1003595_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_000284457.1\|1003831_1004161_-	staphostatin B	NA	NA	NA	NA
WP_047213328.1\|1004198_1005380_-\|protease	cysteine protease staphopain B	NA	NA	NA	NA
WP_047213330.1\|1005461_1006535_-	Glu-specific serine endopeptidase SspA	A0A2H4PQP7	Staphylococcus_phage	3.3e-15	31.7
WP_000777561.1\|1007062_1008217_-	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_046463039.1\|1008411_1009422_-	acyltransferase family protein	NA	NA	NA	NA
WP_000278015.1\|1009574_1009994_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_001788579.1\|1010020_1010131_+	hypothetical protein	NA	NA	NA	NA
WP_115385533.1\|1010202_1013982_-	mannosyl-glycoprotein endo-beta-N-acetylglucosamidase	A0A1J0MFB0	Staphylococcus_phage	1.1e-54	37.6
WP_000491981.1\|1014209_1014644_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000088437.1\|1014798_1015269_-	DUF2538 family protein	NA	NA	NA	NA
WP_031927448.1\|1015316_1016543_-	polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase	NA	NA	NA	NA
WP_069631736.1\|1016991_1018185_+	teichoic acid D-Ala esterase FmtA	NA	NA	NA	NA
WP_000104254.1\|1018721_1019012_-	cytochrome aa3 quinol oxidase subunit IV	NA	NA	NA	NA
WP_000017736.1\|1019008_1019614_-	cytochrome aa3 quinol oxidase subunit III	NA	NA	NA	NA
WP_001010762.1\|1019603_1021592_-	cytochrome aa3 quinol oxidase subunit I	NA	NA	NA	NA
WP_047213337.1\|1021591_1022692_-	cytochrome aa3 quinol oxidase subunit II	NA	NA	NA	NA
WP_031901247.1\|1022996_1023104_+	hypothetical protein	NA	NA	NA	NA
WP_001037831.1\|1023264_1023582_-	DUF5011 domain-containing protein	NA	NA	NA	NA
WP_103225775.1\|1024167_1025734_+\|transposase	IS3-like element ISSau2 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.7e-49	51.8

DBSCAN-SWA_5

1278271 : 1331541

Staphylococcus_phage(25.81%)

tail,portal,integrase,head,transposase,terminase,protease,tRNA

attL 1282773:1282788|attR 1323162:1323177

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001001521.1\|1278271_1279816_+\|tRNA	tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB	NA	NA	NA	NA
WP_000282386.1\|1279816_1280182_+	hypothetical protein	NA	NA	NA	NA
WP_000842277.1\|1280208_1280700_+	energy coupling factor transporter S component ThiW	NA	NA	NA	NA
WP_000073332.1\|1281002_1283621_+	DNA mismatch repair protein MutS	E3T5Q7	Cafeteria_roenbergensis_virus	5.0e-41	23.7
1282773:1282788	attL	NA	NA	NA	NA
WP_000516257.1\|1283633_1285643_+	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	5.3e-59	29.5
WP_001077635.1\|1285648_1286191_+	glycerol-3-phosphate responsive antiterminator	NA	NA	NA	NA
WP_001103747.1\|1286665_1287484_+	aquaporin family protein	M1H4F4	Acanthocystis_turfacea_Chlorella_virus	3.1e-26	35.1
WP_000417379.1\|1287568_1289065_+	glycerol kinase GlpK	NA	NA	NA	NA
WP_001218598.1\|1289222_1290896_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_000136955.1\|1291045_1291960_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_001798536.1\|1291977_1292913_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_000561359.1\|1292927_1293161_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_001807150.1\|1293422_1294742_-\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_000448078.1\|1294902_1295379_-	glutathione peroxidase	Q70H87	Fowlpox_virus	1.2e-22	38.0
WP_031927515.1\|1295490_1296729_+	GTPase HflX	NA	NA	NA	NA
WP_000652044.1\|1296747_1297986_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000624945.1\|1298228_1298597_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_001126603.1\|1298615_1299956_+	type I glutamate--ammonia ligase	NA	NA	NA	NA
WP_031860514.1\|1300095_1300812_-\|integrase	site-specific integrase	A0A0C5AN64	Paenibacillus_phage	3.1e-22	34.7
WP_108630597.1\|1300933_1301224_-	Arm DNA-binding domain-containing protein	A0A1W6JQD3	Staphylococcus_phage	7.0e-05	51.9
WP_047213408.1\|1301276_1301972_-	hypothetical protein	A0A2H4J5B8	uncultured_Caudovirales_phage	1.8e-06	40.9
WP_115385547.1\|1301983_1302367_-	hypothetical protein	NA	NA	NA	NA
WP_047212960.1\|1302562_1303882_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
WP_000664916.1\|1304038_1304431_-	helix-turn-helix domain-containing protein	A0A2I6PE55	Staphylococcus_phage	2.7e-28	53.6
WP_001209962.1\|1304598_1304817_+	DUF739 family protein	A0A2I6PE94	Staphylococcus_phage	4.9e-19	62.5
WP_000932237.1\|1304843_1305119_+	hypothetical protein	NA	NA	NA	NA
WP_000800340.1\|1305542_1305749_-	hypothetical protein	A1BTY8	Staphylococcus_virus	4.3e-25	75.0
WP_001157026.1\|1305808_1306492_+	phage repressor protein	A9CR56	Staphylococcus_phage	8.0e-108	86.0
WP_115385548.1\|1306590_1306752_+	DUF1270 family protein	R4IH12	Staphylococcus_phage	2.3e-13	69.8
WP_031927615.1\|1306839_1307157_+	DUF2482 family protein	W5RAK4	Staphylococcus_phage	9.0e-30	74.5
WP_000786635.1\|1307146_1307413_+	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	3.9e-18	53.6
WP_001002734.1\|1307417_1308668_+	helicase SNF2	A0A1B1P7L4	Bacillus_phage	1.8e-134	57.8
WP_025174483.1\|1308658_1308976_+	hypothetical protein	A0A2P0ZLA7	Lactobacillus_phage	7.1e-19	43.2
WP_000160835.1\|1308968_1309274_+	hypothetical protein	A0A1B1P7M6	Bacillus_phage	5.8e-26	59.3
WP_031927619.1\|1309263_1311090_+	AAA family ATPase	A0A1B1P7N0	Bacillus_phage	2.6e-166	56.3
WP_001250666.1\|1311107_1311314_+	hypothetical protein	NA	NA	NA	NA
WP_000140895.1\|1311359_1311842_+	DUF669 domain-containing protein	A0A2H4J1S8	uncultured_Caudovirales_phage	2.9e-19	37.3
WP_000560476.1\|1312123_1313842_+	hypothetical protein	A0A1B1P7M5	Bacillus_phage	1.9e-211	63.6
WP_000394569.1\|1313945_1314335_+	hypothetical protein	U3PG42	Staphylococcus_phage	4.5e-07	51.9
WP_000792984.1\|1314410_1314716_+	hypothetical protein	A0A2H4JF73	uncultured_Caudovirales_phage	6.2e-36	73.7
WP_000231299.1\|1314738_1315209_-	hypothetical protein	NA	NA	NA	NA
WP_000584491.1\|1315629_1315821_+	hypothetical protein	NA	NA	NA	NA
WP_000276481.1\|1315852_1317727_+	DNA primase	A0A1B1P7L5	Bacillus_phage	1.1e-210	57.6
WP_000933402.1\|1318031_1318523_+	hypothetical protein	S5MAA9	Brevibacillus_phage	7.4e-07	30.0
WP_000870118.1\|1318955_1319246_+	HNH endonuclease	D2XR61	Bacillus_phage	1.3e-19	43.2
WP_000868798.1\|1319564_1319897_+	hypothetical protein	NA	NA	NA	NA
WP_046463075.1\|1319880_1321524_+\|terminase	terminase large subunit	A0A0U4B089	Bacillus_phage	8.4e-180	57.3
WP_000523761.1\|1321539_1322676_+\|portal	phage portal protein	A0A2H4JBZ5	uncultured_Caudovirales_phage	7.8e-84	41.4
WP_047213417.1\|1322675_1323362_+\|protease	Clp protease ClpP	A0A2H4J8Y7	uncultured_Caudovirales_phage	1.4e-43	49.5
1323162:1323177	attR	NA	NA	NA	NA
WP_000152780.1\|1323388_1324558_+	hypothetical protein	A0A0U4JIF4	Bacillus_phage	1.2e-98	50.5
WP_000406284.1\|1324579_1324885_+	hypothetical protein	A0A059T7R0	Listeria_phage	6.0e-15	44.8
WP_000744618.1\|1324859_1325204_+\|head	phage head closure protein	NA	NA	NA	NA
WP_000114215.1\|1325187_1325526_+	hypothetical protein	NA	NA	NA	NA
WP_000072314.1\|1325525_1325963_+	hypothetical protein	NA	NA	NA	NA
WP_000213868.1\|1325968_1326652_+	hypothetical protein	NA	NA	NA	NA
WP_000021684.1\|1326679_1327030_+	hypothetical protein	NA	NA	NA	NA
WP_000159313.1\|1327077_1327302_+	hypothetical protein	NA	NA	NA	NA
WP_031927625.1\|1327359_1331541_+\|tail	phage tail tape measure protein	Q9T0X1	Lactobacillus_phage	3.2e-58	42.6

DBSCAN-SWA_6

1335729 : 1342175

Staphylococcus_phage(83.33%)

holin,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000569801.1\|1335729_1336140_+	hypothetical protein	A0A1I9KKA6	Lactobacillus_phage	3.9e-09	32.8
WP_000665466.1\|1336174_1336489_+	hypothetical protein	NA	NA	NA	NA
WP_047213423.1\|1336472_1336856_+\|holin	phage holin family protein	H9A0W5	Staphylococcus_phage	4.3e-18	39.2
WP_031927627.1\|1336920_1337841_+	N-acetylmuramoyl-L-alanine amidase	A0A1W6JQL2	Staphylococcus_phage	1.2e-66	50.2
WP_001793526.1\|1338317_1338515_+	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	9.9e-11	50.0
WP_001019311.1\|1338708_1339212_+	hypothetical protein	NA	NA	NA	NA
WP_000459699.1\|1339224_1339539_+	hypothetical protein	NA	NA	NA	NA
WP_000907423.1\|1339538_1339967_+	hypothetical protein	NA	NA	NA	NA
WP_000997672.1\|1340370_1340580_+	helix-turn-helix domain-containing protein	A0A1W6JNK0	Staphylococcus_phage	1.9e-12	59.4
WP_052724874.1\|1340834_1342175_+\|capsid	minor capsid protein	A0A1J0MFV1	Staphylococcus_phage	7.0e-140	58.7

DBSCAN-SWA_7

1619640 : 1627952

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1619640_1620426_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924216.1\|1620551_1621442_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001062177.1\|1621451_1622798_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
WP_000683926.1\|1622911_1624012_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	2.3e-08	30.6
WP_000624574.1\|1624014_1624692_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1624822_1625929_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217266.1\|1626152_1627952_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	1.3e-53	36.3

DBSCAN-SWA_8

1697489 : 1706532

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1697489_1698008_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_042908036.1\|1698029_1700303_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.1e-64	29.3
WP_000749803.1\|1700505_1702785_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1703059_1703320_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1703338_1704478_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019170.1\|1704500_1705526_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005767.1\|1705527_1706532_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_9

1833560 : 1890336

Staphylococcus_phage(95.45%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_047213547.1\|1833560_1840100_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	9.5e-291	92.5
WP_000836469.1\|1840425_1840737_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
WP_001108719.1\|1840758_1843173_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.3
WP_001025061.1\|1843463_1844645_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_000526539.1\|1844754_1845708_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|1845704_1846268_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757543.1\|1846387_1846789_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266089.1\|1847360_1848188_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_072357767.1\|1848190_1848310_-	hypothetical protein	NA	NA	NA	NA
WP_001196354.1\|1848421_1849423_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008551.1\|1849544_1850009_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_047213550.1\|1850021_1851203_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	5.1e-227	99.7
WP_000493884.1\|1851213_1851846_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.4e-111	98.6
WP_000384178.1\|1851852_1852884_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	6.9e-196	98.8
WP_047213554.1\|1853376_1854879_-	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	8.6e-30	98.6
WP_000221188.1\|1855399_1855714_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.8e-52	97.1
WP_115385562.1\|1855713_1857006_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.7e-224	97.4
WP_000163240.1\|1857023_1857419_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	2.4e-72	99.2
WP_001032833.1\|1857768_1858623_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1858898_1859123_-	hypothetical protein	NA	NA	NA	NA
WP_000671048.1\|1859321_1859792_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	4.8e-80	96.8
WP_001153740.1\|1859904_1860348_+	competence protein ComK	NA	NA	NA	NA
WP_001030469.1\|1860334_1860778_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
WP_001168909.1\|1861075_1861711_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1862147_1862861_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|1863118_1863421_+	hypothetical protein	NA	NA	NA	NA
WP_001200550.1\|1863676_1864042_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.2e-59	98.3
WP_000623473.1\|1864038_1864392_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	4.2e-20	77.8
WP_000453315.1\|1864641_1865475_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.2e-158	99.6
WP_000366163.1\|1865686_1866595_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
WP_000933822.1\|1866719_1867913_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109907.1\|1868284_1869877_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
WP_115385603.1\|1870171_1870918_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	3.9e-140	97.2
WP_000672018.1\|1870922_1871396_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	1.0e-82	97.5
WP_000718107.1\|1871461_1871719_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778513.1\|1871715_1872717_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	8.2e-186	97.3
WP_000348367.1\|1872721_1874200_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.9e-282	96.7
WP_072357839.1\|1874358_1874814_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	1.4e-79	98.6
WP_072357764.1\|1875117_1875768_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	9.5e-34	67.6
WP_000070657.1\|1875849_1876845_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	2.9e-74	96.8
WP_047213559.1\|1876919_1877546_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	2.8e-75	92.4
WP_000627546.1\|1877586_1877928_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	3.0e-55	94.7
WP_000414223.1\|1878028_1878601_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	7.1e-25	93.1
WP_000864137.1\|1878798_1879356_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.0e-77	96.2
WP_000747794.1\|1879983_1880427_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000742593.1\|1880746_1881196_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_047213567.1\|1881831_1883022_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	1.5e-45	34.7
WP_000028659.1\|1883014_1884571_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	2.3e-288	99.4
WP_001038741.1\|1884934_1885654_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	4.0e-126	95.8
WP_001038864.1\|1885779_1886499_-\|protease	serine protease	A0A2H4PQP7	Staphylococcus_phage	2.4e-123	92.9
WP_001039451.1\|1886556_1887279_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	8.1e-127	95.8
WP_001092761.1\|1889065_1889644_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	1.5e-67	74.0
WP_025174462.1\|1890117_1890336_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	4.1e-26	83.3

DBSCAN-SWA_10

2004329 : 2079151

106

Staphylococcus_phage(88.61%)

portal,head,integrase,holin,capsid,terminase,protease,tail

attL 2013625:2013641|attR 2082900:2082916

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000827765.1\|2004329_2005496_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434533.1\|2005526_2005853_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|2006143_2006317_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011539.1\|2006297_2006900_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040872.1\|2007168_2007990_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	7.9e-70	53.1
WP_000284433.1\|2007982_2009452_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	3.5e-108	45.1
WP_000897635.1\|2009635_2010712_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177828.1\|2010731_2011526_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|2011597_2011705_+	hypothetical protein	NA	NA	NA	NA
WP_000323164.1\|2011715_2013278_-	SLC13 family permease	NA	NA	NA	NA
WP_000275712.1\|2013483_2014581_-	pectate lyase	U5PWM6	Bacillus_phage	1.5e-47	34.6
2013625:2013641	attL	NA	NA	NA	NA
WP_000149686.1\|2014952_2015513_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2015565_2016495_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|2016687_2016861_-	hypothetical protein	NA	NA	NA	NA
WP_042908133.1\|2016912_2018292_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181312.1\|2018411_2019440_-	lactonase family protein	NA	NA	NA	NA
WP_000205106.1\|2019710_2020112_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
WP_000267034.1\|2020168_2020342_-	hypothetical protein	NA	NA	NA	NA
WP_001188066.1\|2020792_2021833_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713075.1\|2021889_2022732_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_061735094.1\|2022728_2023286_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|2023345_2023870_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|2023990_2024554_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221656.1\|2024619_2025360_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_047213607.1\|2025359_2026232_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645727.1\|2026228_2026909_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991298.1\|2026909_2027806_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|2027802_2028183_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681972.1\|2028440_2028617_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|2028859_2028958_-	hypothetical protein	NA	NA	NA	NA
WP_001068524.1\|2029157_2030444_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000671713.1\|2030714_2031005_-	MAP domain-containing protein	NA	NA	NA	NA
WP_031927804.1\|2031015_2032455_-	MAP domain-containing protein	NA	NA	NA	NA
WP_000669791.1\|2033422_2033602_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	1.4e-24	98.3
WP_001791826.1\|2033912_2034173_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702263.1\|2034224_2034575_-	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_001110821.1\|2035085_2035382_-	peptidoglycan hydrolase	A0A1P8L6B4	Staphylococcus_phage	1.1e-48	94.9
WP_000920038.1\|2036071_2036563_-	staphylokinase	A0A1W6JQ12	Staphylococcus_phage	4.7e-86	99.4
WP_107375239.1\|2036753_2037509_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	9.9e-152	99.6
WP_000611512.1\|2037520_2037775_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_031762631.1\|2037826_2037934_+	hypothetical protein	NA	NA	NA	NA
WP_115385564.1\|2037986_2038163_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	6.5e-22	96.6
WP_000539688.1\|2038312_2038609_-	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
WP_061839455.1\|2038666_2038954_-	hypothetical protein	D2JLG1	Staphylococcus_phage	1.4e-42	98.9
WP_001153681.1\|2039000_2039153_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_115385565.1\|2039142_2042928_-	hypothetical protein	D2JLF9	Staphylococcus_phage	0.0e+00	99.4
WP_001154327.1\|2042943_2044434_-\|tail	phage tail protein	D2JLF8	Staphylococcus_phage	8.2e-299	100.0
WP_115385566.1\|2044433_2049083_-\|tail	phage tail tape measure protein	A0A1V0E5H1	Staphylococcus_phage	0.0e+00	99.9
WP_000570353.1\|2049138_2049261_-	hypothetical protein	D2JLF6	Staphylococcus_phage	6.9e-15	100.0
WP_000442602.1\|2049320_2049767_-	hypothetical protein	O80053	Staphylococcus_phage	1.9e-73	96.6
WP_000570652.1\|2049831_2050785_-\|tail	phage tail protein	A7TWD0	Staphylococcus_phage	6.2e-175	100.0
WP_000611452.1\|2050785_2051166_-	hypothetical protein	D2JLF3	Staphylococcus_phage	5.8e-68	100.0
WP_000501244.1\|2051162_2051540_-	HK97 gp10 family phage protein	D2JLF2	Staphylococcus_phage	1.1e-61	100.0
WP_000975314.1\|2051539_2051875_-\|head,tail	head-tail adaptor protein	A7TWC7	Staphylococcus_phage	1.1e-59	100.0
WP_001177483.1\|2051861_2052194_-\|head,tail	phage head-tail adapter protein	D2JLF0	Staphylococcus_phage	2.1e-58	100.0
WP_001252099.1\|2052202_2052361_-	hypothetical protein	D2JLE9	Staphylococcus_phage	3.2e-20	100.0
WP_115385567.1\|2052396_2053644_-\|capsid	phage major capsid protein	A7TWC4	Staphylococcus_phage	4.3e-208	99.8
WP_000032525.1\|2053731_2054316_-\|head,protease	HK97 family phage prohead protease	D2JLE7	Staphylococcus_phage	9.8e-107	100.0
WP_072433585.1\|2054308_2055499_-\|portal	phage portal protein	R9QSV8	Staphylococcus_phage	5.3e-224	100.0
WP_000644966.1\|2055564_2055804_-	membrane protein	R9QT78	Staphylococcus_phage	5.3e-35	100.0
WP_000133306.1\|2055778_2057473_-\|terminase	terminase	A0A1V0E5G5	Staphylococcus_phage	0.0e+00	100.0
WP_000919026.1\|2057475_2057943_-\|terminase	phage terminase small subunit P27 family	D2JLE3	Staphylococcus_phage	1.1e-81	100.0
WP_000817289.1\|2058072_2058417_-	HNH endonuclease	D2JLE2	Staphylococcus_phage	4.2e-65	100.0
WP_000406191.1\|2058432_2058885_-	nucleoside triphosphate pyrophosphohydrolase family protein	D2JLE1	Staphylococcus_phage	1.4e-79	100.0
WP_115385568.1\|2058999_2059461_-	hypothetical protein	R9QT84	Staphylococcus_phage	8.1e-72	100.0
WP_000265041.1\|2059483_2059684_-	DUF1514 family protein	R9QT57	Staphylococcus_phage	1.1e-28	100.0
WP_000595239.1\|2059683_2059833_-	transcriptional activator RinB	A0A1P8L6D7	Staphylococcus_phage	3.7e-18	100.0
WP_033859700.1\|2059829_2060036_-	DUF1381 domain-containing protein	Q4ZCV6	Staphylococcus_virus	7.1e-20	98.5
WP_057520733.1\|2060032_2060278_-	hypothetical protein	A0A0H4ITX2	Staphylococcus_phage	3.2e-35	97.5
WP_031911468.1\|2060314_2060824_-	dUTP pyrophosphatase	A9CR88	Staphylococcus_phage	1.2e-89	99.4
WP_115385569.1\|2060816_2061059_-	hypothetical protein	A0A2I6PF40	Staphylococcus_phage	3.5e-34	96.2
WP_115385570.1\|2061048_2061300_-	DUF1024 family protein	A0A2K9VBU0	Staphylococcus_phage	1.2e-37	98.8
WP_115385571.1\|2061292_2061568_-	hypothetical protein	A0A0H4ISQ8	Staphylococcus_phage	4.0e-42	96.7
WP_015978309.1\|2061567_2061972_-	hypothetical protein	A0A0H4IPW3	Staphylococcus_phage	1.6e-71	100.0
WP_000132211.1\|2061985_2062228_-	hypothetical protein	A0A0H4ITW9	Staphylococcus_phage	4.7e-39	97.5
WP_000029390.1\|2062231_2062588_-	hypothetical protein	M1RZB8	Staphylococcus_phage	1.6e-59	99.2
WP_001187233.1\|2062588_2062774_-	DUF3113 family protein	M1SNY0	Staphylococcus_phage	1.4e-27	100.0
WP_000049810.1\|2062778_2063183_-	DUF1064 domain-containing protein	A0A0H4ISQ5	Staphylococcus_phage	9.0e-67	100.0
WP_001123688.1\|2063192_2063414_-	DUF3269 family protein	Q9G021	Staphylococcus_phage	1.3e-35	100.0
WP_001024406.1\|2063416_2063632_-	hypothetical protein	A9CR72	Staphylococcus_phage	2.8e-35	100.0
WP_001106169.1\|2063628_2064870_-	AAA family ATPase	C8CGZ3	Staphylococcus_phage	3.3e-229	99.8
WP_001132247.1\|2064866_2065223_-	hypothetical protein	B7T0A8	Staphylococcus_virus	2.2e-61	97.5
WP_115385572.1\|2065222_2066041_-	DnaD domain protein	Q8SDW2	Staphylococcus_phage	8.9e-106	92.6
WP_115385573.1\|2066012_2066708_-	hypothetical protein	A0A0E3XBQ6	Staphylococcus_phage	1.3e-129	96.5
WP_115385574.1\|2066719_2067178_-	single-stranded DNA-binding protein	A0A0E3XC62	Staphylococcus_phage	4.2e-52	99.1
WP_115385575.1\|2067177_2067816_-	ERF family protein	Q9MBS2	Staphylococcus_prophage	1.1e-114	99.5
WP_115385576.1\|2067815_2068295_-	siphovirus Gp157 family protein	Q4ZAD7	Staphylococcus_virus	5.8e-81	98.7
WP_000291068.1\|2068308_2068569_-	DUF1108 family protein	C8CGY6	Staphylococcus_phage	8.9e-44	100.0
WP_000165365.1\|2068573_2068876_-	DUF2482 family protein	A0A0F6N3N3	Staphylococcus_phage	7.0e-48	99.0
WP_000066020.1\|2068968_2069130_-	DUF1270 domain-containing protein	A0A2I6PDF7	Staphylococcus_phage	1.9e-20	100.0
WP_001120935.1\|2069126_2069447_-	DUF771 domain-containing protein	Q4ZDR7	Staphylococcus_virus	1.5e-56	100.0
WP_000801108.1\|2069505_2069733_+	hypothetical protein	A7TWL9	Staphylococcus_phage	1.7e-38	100.0
WP_000389906.1\|2069734_2069926_-	hypothetical protein	A7TWL8	Staphylococcus_phage	2.8e-26	100.0
WP_000768245.1\|2069975_2070332_+	DUF2513 domain-containing protein	A0A1P8L6H1	Staphylococcus_phage	6.1e-59	100.0
WP_001148859.1\|2070326_2070521_-	hypothetical protein	A0A1P8L6G6	Staphylococcus_phage	4.3e-19	100.0
WP_031879807.1\|2070536_2071292_-	oxidoreductase	A0A0H4J326	Staphylococcus_phage	7.4e-139	99.6
WP_000351243.1\|2071348_2071888_+	hypothetical protein	A7TW92	Staphylococcus_phage	1.7e-97	100.0
WP_000435341.1\|2071911_2072172_-	transcriptional regulator	A7TW91	Staphylococcus_phage	2.7e-40	100.0
WP_000338186.1\|2072189_2072414_-	DUF739 family protein	A7TW90	Staphylococcus_phage	4.5e-36	100.0
WP_001208482.1\|2072571_2073342_+	helix-turn-helix domain-containing protein	A0A1P8L6G7	Staphylococcus_phage	6.2e-141	100.0
WP_000694770.1\|2073541_2073724_+	hypothetical protein	A0A2I6PDF8	Staphylococcus_phage	9.1e-27	98.3
WP_001013104.1\|2073759_2073906_+	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.1e-14	89.6
WP_000191459.1\|2073902_2074517_-	hypothetical protein	A7TW88	Staphylococcus_phage	7.9e-107	100.0
WP_000857174.1\|2074624_2075662_+\|integrase	site-specific integrase	A7TWL3	Staphylococcus_phage	1.7e-178	99.7
WP_047213639.1\|2077057_2078074_-	bi-component leukocidin LukGH subunit G	A0A1X9IGW5	Staphylococcus_phage	1.1e-25	30.2
WP_000791409.1\|2078095_2079151_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	1.9e-36	34.6
2082900:2082916	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CP022898.1|WP_078103419.1|998938_999016_+|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP022898.1|WP_078103419.1|998938_999016_+|hypothetical-protein

998938_999016_+

25 aa aa

979088-1025734

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP022898_10	Orphan	10.1\|2783362\|31\|NZ_CP022898\|CRISPRCasFinder	2783362-2783392	31	1023994-1024024	0

1. spacer 10.1|2783362|31|NZ_CP022898|CRISPRCasFinder matches to NZ_CP022898 position: 1023994-1024024, mismatch: 0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022898

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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