CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022719	Staphylococcus aureus strain 45 plasmid pPS00086.1A.1, complete sequence	0 crisprs	csa3	0	0	1	0
NZ_CP022718	Staphylococcus aureus strain 45 chromosome, complete genome	5 crisprs	cas3,DEDDh,DinG,csa3,WYL	3	3	9	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 17687

Streptococcus_phage(20.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000122363.1\|863_1169_+	recombinase	NA	NA	NA	NA
WP_000390798.1\|1193_1493_+	recombinase	NA	NA	NA	NA
WP_000273005.1\|1586_2132_+	hypothetical protein	NA	NA	NA	NA
WP_000145511.1\|2515_3376_+	replication initiation protein	NA	NA	NA	NA
WP_000761341.1\|3462_3804_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_106873653.1\|4042_4114_-	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_000466619.1\|4262_4448_+	hypothetical protein	NA	NA	NA	NA
WP_000843758.1\|4666_5410_-	DUF536 domain-containing protein	NA	NA	NA	NA
WP_001641725.1\|5820_6096_+	replication initiation protein	NA	NA	NA	NA
WP_001789670.1\|6383_6497_+	hypothetical protein	NA	NA	NA	NA
WP_000616820.1\|8000_8618_+	cadmium resistance transporter CadD	NA	NA	NA	NA
WP_000119691.1\|8636_8984_+	helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	6.4e-13	36.8
WP_001791613.1\|9152_9245_+	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_000072391.1\|9456_10431_+	DUF4062 domain-containing protein	NA	NA	NA	NA
WP_000164958.1\|10550_11366_-	AAA family ATPase	A0A0M3LP72	Mannheimia_phage	4.0e-05	29.8
WP_000690638.1\|12773_13367_-	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	1.5e-41	51.1
WP_001284653.1\|13630_14011_-	penicillinase repressor BlaI	NA	NA	NA	NA
WP_001096385.1\|14000_15758_-	beta-lactam sensor/signal transducer BlaR1	NA	NA	NA	NA
WP_000733289.1\|15864_16710_+	penicillin-hydrolyzing class A beta-lactamase BlaZ	A0A1B0VBP7	Salmonella_phage	1.2e-31	34.4
WP_001566953.1\|17078_17687_+	recombinase family protein	E5FFF9	Burkholderia_phage	6.2e-11	28.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP022718

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022718_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022718_1

775215-775295

Unclear

Consensus_repeat	Method
TTCTTTATGTTGGGGCCCCGCCAACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022718_1

>merge|NZ_CP022718|1|775215-775295|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACTTGCATTGTTTGTAGAATTTCTTTTCGAAATTCTTTATGTTGGGGCCCCGCCAACT

>NZ_CP022718|1|1|775215-775295|CRISPRCasFinder
TTCTTTATGTTGGGGCCCCGCCAACT	TGCATTGTTTGTAGAATTTCTTTTCGAAA
TTCTTTATGTTGGGGCCCCGCCAACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022718.1\|WP_010956549.1\|766401_767512_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_CP022718.1\|WP_000506531.1\|763555_766087_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
NZ_CP022718.1\|WP_000617735.1\|762569_763142_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
NZ_CP022718.1\|WP_000753321.1\|767920_768760_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP022718.1\|WP_072360986.1\|767665_767773_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022718.1\|WP_000662681.1\|772078_774925_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP022718.1\|WP_001790092.1\|766128_766233_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022718.1\|WP_000369722.1\|781075_781987_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NZ_CP022718.1\|WP_001049165.1\|784606_785194_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_CP022718.1\|WP_001224793.1\|777316_777802_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP022718.1\|WP_000229236.1\|770085_772071_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP022718.1\|WP_000538141.1\|768933_769584_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NZ_CP022718.1\|WP_000816304.1\|785436_786339_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NZ_CP022718.1\|WP_000638419.1\|769580_769817_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NZ_CP022718.1\|WP_000513308.1\|776469_777309_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP022718.1\|WP_000057542.1\|777809_779249_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NZ_CP022718.1\|WP_001248939.1\|781983_782979_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_CP022718.1\|WP_000006551.1\|783089_784034_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP022718.1\|WP_000134963.1\|779315_780251_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP022718.1\|WP_000958224.1\|775531_776464_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459

Protein	Function_ID	Function_description	E-value
NZ_CP022718.1\|WP_000134963.1\|779315_780251_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NZ_CP022718.1\|WP_010956549.1\|766401_767512_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_CP022718.1\|WP_000506531.1\|763555_766087_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
NZ_CP022718.1\|WP_001224793.1\|777316_777802_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NZ_CP022718.1\|WP_000753321.1\|767920_768760_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.82721e-42
NZ_CP022718.1\|WP_000369722.1\|781075_781987_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NZ_CP022718.1\|WP_000662681.1\|772078_774925_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP022718.1\|WP_001049165.1\|784606_785194_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NZ_CP022718.1\|WP_000229236.1\|770085_772071_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP022718.1\|WP_000538141.1\|768933_769584_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NZ_CP022718.1\|WP_000816304.1\|785436_786339_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
NZ_CP022718.1\|WP_000638419.1\|769580_769817_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NZ_CP022718.1\|WP_000513308.1\|776469_777309_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119
NZ_CP022718.1\|WP_000057542.1\|777809_779249_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	3.57983e-06
NZ_CP022718.1\|WP_001248939.1\|781983_782979_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NZ_CP022718.1\|WP_000006551.1\|783089_784034_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NZ_CP022718.1\|WP_000617735.1\|762569_763142_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
NZ_CP022718.1\|WP_000958224.1\|775531_776464_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170

>NZ_CP022718.1|WP_000662681.1|772078_774925_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NZ_CP022718.1|WP_000229236.1|770085_772071_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIEEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQIRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NZ_CP022718.1|WP_000638419.1|769580_769817_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NZ_CP022718.1|WP_000538141.1|768933_769584_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NZ_CP022718.1|WP_000753321.1|767920_768760_+|CHAP-domain-containing-protein
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKTPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NZ_CP022718.1|WP_072360986.1|767665_767773_+|hypothetical-protein
MYLLKQHMQCAFSNITYGDFQGIELIVENVLNYMV
>NZ_CP022718.1|WP_010956549.1|766401_767512_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>NZ_CP022718.1|WP_001790092.1|766128_766233_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSFKKSV
>NZ_CP022718.1|WP_000506531.1|763555_766087_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>NZ_CP022718.1|WP_000617735.1|762569_763142_+|ribosome-associated-translation-inhibitor-RaiA
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>NZ_CP022718.1|WP_000958224.1|775531_776464_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NZ_CP022718.1|WP_000513308.1|776469_777309_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NZ_CP022718.1|WP_001224793.1|777316_777802_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP022718.1|WP_000057542.1|777809_779249_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP022718.1|WP_000134963.1|779315_780251_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NZ_CP022718.1|WP_000369722.1|781075_781987_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NZ_CP022718.1|WP_001248939.1|781983_782979_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NZ_CP022718.1|WP_000006551.1|783089_784034_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NZ_CP022718.1|WP_001049165.1|784606_785194_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NZ_CP022718.1|WP_000816304.1|785436_786339_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE

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Crispr_ID: NZ_CP022718_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022718_2

780708-780791

Unclear

Consensus_repeat	Method
TCTGTGTTGGCGCCCACACCCCAACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022718_2

>merge|NZ_CP022718|2|780708-780791|CRISPRCasFinder
TCTGTGTTGGCGCCCACACCCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCACACCCCAACT

>NZ_CP022718|2|2|780708-780791|CRISPRCasFinder
TCTGTGTTGGCGCCCACACCCCAACT	CGCATTGCCTGTAGAATTTCTTTTCGAAATTC
TCTGTGTTGGGGCCCACACCCCAACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022718.1\|WP_001074749.1\|790639_791830_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CP022718.1\|WP_000654030.1\|788425_789439_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP022718.1\|WP_000134963.1\|779315_780251_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP022718.1\|WP_000958224.1\|775531_776464_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP022718.1\|WP_000753321.1\|767920_768760_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP022718.1\|WP_000369722.1\|781075_781987_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NZ_CP022718.1\|WP_000662681.1\|772078_774925_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP022718.1\|WP_000070826.1\|787041_787671_+\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NZ_CP022718.1\|WP_000279414.1\|789491_790502_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NZ_CP022718.1\|WP_001049165.1\|784606_785194_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_CP022718.1\|WP_000229236.1\|770085_772071_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP022718.1\|WP_000538141.1\|768933_769584_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NZ_CP022718.1\|WP_001260098.1\|791951_792713_+\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
NZ_CP022718.1\|WP_000638419.1\|769580_769817_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NZ_CP022718.1\|WP_000513308.1\|776469_777309_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP022718.1\|WP_000057542.1\|777809_779249_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NZ_CP022718.1\|WP_001248939.1\|781983_782979_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_CP022718.1\|WP_000006551.1\|783089_784034_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP022718.1\|WP_000816304.1\|785436_786339_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NZ_CP022718.1\|WP_001224793.1\|777316_777802_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053

Protein	Function_ID	Function_description	E-value
NZ_CP022718.1\|WP_001074749.1\|790639_791830_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP022718.1\|WP_000654030.1\|788425_789439_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
NZ_CP022718.1\|WP_000134963.1\|779315_780251_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NZ_CP022718.1\|WP_000958224.1\|775531_776464_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NZ_CP022718.1\|WP_000753321.1\|767920_768760_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.82721e-42
NZ_CP022718.1\|WP_000369722.1\|781075_781987_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NZ_CP022718.1\|WP_000662681.1\|772078_774925_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP022718.1\|WP_000070826.1\|787041_787671_+\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.85535e-05
NZ_CP022718.1\|WP_000279414.1\|789491_790502_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP022718.1\|WP_001049165.1\|784606_785194_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NZ_CP022718.1\|WP_000229236.1\|770085_772071_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP022718.1\|WP_000538141.1\|768933_769584_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NZ_CP022718.1\|WP_001260098.1\|791951_792713_+\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	1.58979e-145
NZ_CP022718.1\|WP_000638419.1\|769580_769817_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NZ_CP022718.1\|WP_000513308.1\|776469_777309_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119
NZ_CP022718.1\|WP_000057542.1\|777809_779249_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	3.57983e-06
NZ_CP022718.1\|WP_001248939.1\|781983_782979_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NZ_CP022718.1\|WP_000006551.1\|783089_784034_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NZ_CP022718.1\|WP_000816304.1\|785436_786339_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
NZ_CP022718.1\|WP_001224793.1\|777316_777802_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30

>NZ_CP022718.1|WP_000134963.1|779315_780251_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NZ_CP022718.1|WP_000057542.1|777809_779249_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP022718.1|WP_001224793.1|777316_777802_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP022718.1|WP_000513308.1|776469_777309_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NZ_CP022718.1|WP_000958224.1|775531_776464_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NZ_CP022718.1|WP_000662681.1|772078_774925_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NZ_CP022718.1|WP_000229236.1|770085_772071_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIEEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQIRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NZ_CP022718.1|WP_000638419.1|769580_769817_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NZ_CP022718.1|WP_000538141.1|768933_769584_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NZ_CP022718.1|WP_000753321.1|767920_768760_+|CHAP-domain-containing-protein
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKTPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>NZ_CP022718.1|WP_000369722.1|781075_781987_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NZ_CP022718.1|WP_001248939.1|781983_782979_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NZ_CP022718.1|WP_000006551.1|783089_784034_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NZ_CP022718.1|WP_001049165.1|784606_785194_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NZ_CP022718.1|WP_000816304.1|785436_786339_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>NZ_CP022718.1|WP_000070826.1|787041_787671_+|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>NZ_CP022718.1|WP_000654030.1|788425_789439_+|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>NZ_CP022718.1|WP_000279414.1|789491_790502_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>NZ_CP022718.1|WP_001074749.1|790639_791830_+|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
>NZ_CP022718.1|WP_001260098.1|791951_792713_+|triose-phosphate-isomerase
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKYGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK

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Crispr_ID: NZ_CP022718_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022718_3

1652957-1653042

Orphan

Consensus_repeat	Method
TCTGTGTTGGGGCCCCATCCCCAACTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022718_3

>merge|NZ_CP022718|3|1652957-1653042|CRISPRCasFinder
TCTGTGTTGGGGCCCCATCCCCAACTTGCACATTATTGAAAGCTGACTTTTGGTCAGCTTCTGTGTTGGGGCCCCGTCCCCAACTT

>NZ_CP022718|3|3|1652957-1653042|CRISPRCasFinder
TCTGTGTTGGGGCCCCATCCCCAACTT	GCACATTATTGAAAGCTGACTTTTGGTCAGCT
TCTGTGTTGGGGCCCCGTCCCCAACTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022718.1\|WP_000648617.1\|1641694_1642318_-\|uridine-kinase	unknown	unknown	gnl\|CDD\|235492
NZ_CP022718.1\|WP_000044799.1\|1660691_1662458_-\|aspartate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234775
NZ_CP022718.1\|WP_000102740.1\|1658022_1659297_+\|replication-associated-recombination-protein-A	unknown	unknown	gnl\|CDD\|237355
NZ_CP022718.1\|WP_001808243.1\|1660230_1660359_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022718.1\|WP_001283315.1\|1649497_1651975_-\|ATP-dependent-RecD-like-DNA-helicase	unknown	unknown	gnl\|CDD\|273632
NZ_CP022718.1\|WP_000137775.1\|1643597_1644521_-\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NZ_CP022718.1\|WP_000848304.1\|1642317_1643586_-\|U32-family-peptidase	unknown	unknown	gnl\|CDD\|223896
NZ_CP022718.1\|WP_000409174.1\|1654343_1655486_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP022718.1\|WP_000342266.1\|1644523_1645162_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP022718.1\|WP_000134779.1\|1645446_1645755_-\|DUF1292-domain-containing-protein	unknown	unknown	gnl\|CDD\|184235
NZ_CP022718.1\|WP_000009238.1\|1657047_1657194_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022718.1\|WP_000066097.1\|1653224_1654343_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP022718.1\|WP_000682646.1\|1659457_1660231_-\|tRNA-threonylcarbamoyladenosine-dehydratase	unknown	unknown	gnl\|CDD\|224100
NZ_CP022718.1\|WP_000704122.1\|1657515_1657938_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224870
NZ_CP022718.1\|WP_000939059.1\|1645769_1646198_-\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|223886
NZ_CP022718.1\|WP_000567029.1\|1651976_1652645_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP022718.1\|WP_000426912.1\|1646201_1646462_-\|IreB-family-regulatory-phosphoprotein	unknown	unknown	gnl\|CDD\|180108
NZ_CP022718.1\|WP_000734070.1\|1646524_1649155_-\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NZ_CP022718.1\|WP_000752909.1\|1657233_1657416_-\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NZ_CP022718.1\|WP_000985872.1\|1655797_1656811_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646

Protein	Function_ID	Function_description	E-value
NZ_CP022718.1\|WP_000648617.1\|1641694_1642318_-\|uridine-kinase	gnl\|CDD\|235492	PRK05480, PRK05480, uridine/cytidine kinase; Provisional.	5.13835e-138
NZ_CP022718.1\|WP_000044799.1\|1660691_1662458_-\|aspartate--tRNA-ligase	gnl\|CDD\|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
NZ_CP022718.1\|WP_000102740.1\|1658022_1659297_+\|replication-associated-recombination-protein-A	gnl\|CDD\|237355	PRK13342, PRK13342, recombination factor protein RarA; Reviewed.	0
NZ_CP022718.1\|WP_001283315.1\|1649497_1651975_-\|ATP-dependent-RecD-like-DNA-helicase	gnl\|CDD\|273632	TIGR01448, recD_rel, helicase, putative, RecD/TraA family. This model describes a family similar to RecD, the exodeoxyribonuclease V alpha chain of TIGR01447. Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. Chlamydia muridarum has both a member of this family and a RecD. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP022718.1\|WP_000137775.1\|1643597_1644521_-\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	4.87045e-104
NZ_CP022718.1\|WP_000848304.1\|1642317_1643586_-\|U32-family-peptidase	gnl\|CDD\|223896	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones].	5.98972e-149
NZ_CP022718.1\|WP_000409174.1\|1654343_1655486_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	0
NZ_CP022718.1\|WP_000342266.1\|1644523_1645162_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.23148e-73
NZ_CP022718.1\|WP_000134779.1\|1645446_1645755_-\|DUF1292-domain-containing-protein	gnl\|CDD\|184235	PRK13678, PRK13678, hypothetical protein; Provisional.	1.28539e-26
NZ_CP022718.1\|WP_000066097.1\|1653224_1654343_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP022718.1\|WP_000682646.1\|1659457_1660231_-\|tRNA-threonylcarbamoyladenosine-dehydratase	gnl\|CDD\|224100	COG1179, COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism].	1.59061e-126
NZ_CP022718.1\|WP_000704122.1\|1657515_1657938_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	5.58388e-46
NZ_CP022718.1\|WP_000939059.1\|1645769_1646198_-\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|223886	COG0816, COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair].	3.40149e-56
NZ_CP022718.1\|WP_000567029.1\|1651976_1652645_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.35833e-16
NZ_CP022718.1\|WP_000426912.1\|1646201_1646462_-\|IreB-family-regulatory-phosphoprotein	gnl\|CDD\|180108	PRK05473, IreB-like, IreB family regulatory phosphoprotein. IreB (EF1202) was characterized in Enterococcus faecalis as a small protein, well-conserved in the Firmicutes. It belongs to a system that includes the Ser/Thr protein kinase IreK, and phosphatase IreP, undergoes phosphorylation on threonine residues, and is involved in regulating cephalosporin resistance. This family was previously named DUF965 by Pfam model pfam06135.	3.05024e-47
NZ_CP022718.1\|WP_000734070.1\|1646524_1649155_-\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NZ_CP022718.1\|WP_000752909.1\|1657233_1657416_-\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	4.22501e-07
NZ_CP022718.1\|WP_000985872.1\|1655797_1656811_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	1.86511e-172

>NZ_CP022718.1|WP_000567029.1|1651976_1652645_-|tetratricopeptide-repeat-protein
MIDQQTIYQYIQNGKIEEALQALFGNIEENPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFFNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDAEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNEDIDEVITHFKEAVTIDPKHLLSQHALKTFTKMKEEE
>NZ_CP022718.1|WP_001283315.1|1649497_1651975_-|ATP-dependent-RecD-like-DNA-helicase
MSDPTLFDYSMIKGTVEAILFQNSDNFYTVLKVDTIETNEDFDTMPTVVGFLPNIVEGDVYTFKGQVVDHPRYGKQLKAETFEKEMPQTKEAIISYLSSDLFKGVGKKTAQNIVNTLGDNAINDILDDHSVLEKVSGLSKKKQKQIAEQISANQESEKIMIRLHDLGFGPKLSMAIYQFYLGDTLTILDRNPYQLIYDIKGIGFNKADQLARNIGIAYNDNERLKAALLYTLEEECIKQGHTYLPINVVIDLTVDVLNYQDEEVIEPEKLDEMLQYLNEEKRLIIDNEQVAIPSLYYSEIKSVQNLFRIKTHTNKLTEIEQSDLQMHIGEIEDANQVNYAASQKEALQTAINSKVMLLTGGPGTGKTTVIKGIVELYAEIHGLSLDYDDYVNDDYPVVLAAPTGRASKRLQESTGLEAMTIHRLIGWNQDTKPEDILENEINARLIIIDEMSMVDTWLFHQFLSAVPLDAQLIFVGDEDQLPSVGPGQVFKDLIESKAIPRVNLTEVYRQQDGSSIIELAHRMKLGQKIDITQRFHDRSFINCQANQIPTVVEKVVTSAVNKGYTMADIQVLAPMYKGNAGIKRLNQVLQDILNPKKKDTREIEFGDVVFRKGDKVLQLVNRPNDNIFNGDIGVIVGIFWAKENALNKDVLVVDFEGNEITFTKQDMMELTHAYCTSIHKSQGSEFPIVIMPIVKQYFRMLQRPILYTGLTRAKTSLVLLGDPEAFDIGLKTNGQARLTQLCTLLKNYFNSEDEEMLENTATNDTGASQTTIDDQVQAPMSSNDSGEVTSDSTKTDINVLTEATMFKIDPMINMGEITPYDFIER
>NZ_CP022718.1|WP_000734070.1|1646524_1649155_-|alanine--tRNA-ligase
MKKLKASEIRQKYLDFFVEKGHMVEPSAPLVPIDDDTLLWINSGVATLKKYFDGRETPKKPRIVNSQKAIRTNDIENVGFTARHHTFFEMLGNFSIGDYFKQEAIEFAWEFLTSDKWMGMEPDKLYVTIHPEDMEAYNIWHKDIGLEESRIIRIEGNFWDIGEGPSGPNTEIFYDRGEAYGQDDPAEEMYPGGENERYLEVWNLVFSEFNHNKDHSYTPLPNKNIDTGMGLERMASVSQNVRTNYETDLFMPIMNEIEKVSGKQYLVNNEQDVAFKVIADHIRTIAFAISDGALPANEGRGYVLRRLLRRAVRFSQTLGINEPFMYKLVDIVADIMEPYYPNVKEKADFIKRVIKSEEERFHETLEDGLAILNELIKKAKATTNEINGKDAFKLYDTYGFPIELTEEIAVQAGLKVDMTTFESEMQQQRDRARQARQNSQSMQVQSEVLKNITSASTFVGYDTATAQTTLTHLIYNGEEVSQVEAGETVYFMLTETPFYAVSGGQVADTGIVYNDNFEIAVSEVTKAPNGQNLHKGVVQFGQVNVGATVSAEVNQNDRRDIQKNHSATHLLHAALKSVLGDHVNQAGSLVEADRLRFDFSHFGPMTNDEIDQVERLVNEEIWKGIDVNIQEMDIASAKEMGAMALFGEKYGDVVRVVNMAPFSIELCGGIHVRNTSEIGLFKIVSESGTGAGVRRIEALTGKAAFLYLEDIQEKFNTMKSQLKVKSDDQVVDKLTQIQDEEKALLKQLEQRDKEITSLKMGNIEDQVEEINGYKVLVTEVDVPNAKAIRSTMDDFKSKLQDTIIILASNVDDKVSMVATVPKSLTNNVKAGDLIKQMAPIVGGKGGGRPDMAQGGGTQPENISKSLSFIKDYIKNL
>NZ_CP022718.1|WP_000426912.1|1646201_1646462_-|IreB-family-regulatory-phosphoprotein
MENFDKTMKFDYEELPTQDVRDVLNNVYRTLDERGYNAVNQIVGYLLSGDPAYIPRQNEARNQIRHIDRDVIMEELVSYYLKEQNK
>NZ_CP022718.1|WP_000939059.1|1645769_1646198_-|Holliday-junction-resolvase-RuvX
MLQHKILGLDVGSRTVGIAISDIMGWTAQGLDTLRINEENNELGIDQLVDIIKKHNVGTVVIGLPKNMNNSIGFRGEASLTYKEKLLEAYPSIEIVMWDERLSTMAAERSLLEADVSRQKRKQVIDKMAAVFILQGYLDSLH
>NZ_CP022718.1|WP_000134779.1|1645446_1645755_-|DUF1292-domain-containing-protein
MTEHNHDSQLEINNEEELLTLFDEEGNEVLYRKVLEFYHPEFKKEYVILAEEGAQSDEDDMIELVPMINEPDESGDGGKLVPIETDEEWDMIEEVVNTEMEE
>NZ_CP022718.1|WP_000342266.1|1644523_1645162_-|O-methyltransferase
MDDLNKKYLIDLHQHQNSSIEVLREFAEVNEVPIVDRLTLDLIKQLIRMNNVKNILEIGTAIGYSSMQFASISDDIHVTTIERNETMIQYAKQNLATYHFENQVRIIEGNALEQFENVNDKVYDMIFIDAAKAQSKKFFEIYTPLLKHQGLVITDNVLYHGFVSDIGIVRSRNVRQMVKKVQDYNEWLIKQPGYTTNFLNIDDGLAISIKGE
>NZ_CP022718.1|WP_000137775.1|1643597_1644521_-|U32-family-peptidase
MTELLVTPKSLSHMETLIDLGADAFVIGEQKFGLRLPGEFNRQQMTEAVALAHKNDKKVYAAVNGLFHNYHLDAVEDYINFLHEIRVDRIIFGDPAVVMYVKAQENPIPLHWNAETLVTNHFQCNYWGKRGASRAVLARELNLDEIINIKENSNVEIEVQVQGMTCMFQSKRMLLGNYYTFQDRQMKIERRNDEQSLLLYDEERQNNYPVYEDYNGTHIMSPNDICLIEELAPFFEAGIDSFKIDGILQTEEYINVVTEQYRQAIDLYNEDPEIYEDEKFMLMDPIEEIQPDHRPFDEGFLYKQTVY
>NZ_CP022718.1|WP_000848304.1|1642317_1643586_-|U32-family-peptidase
MKTIEEIKSTPKTVMKKPELLAPAGNLEKLKIAVHYGADAVFLGGQEYGLRSNADNFTMEEIAEGVEFANRYGAKIYVTTNIIAHDENIEGLESYLRNLEKTGATGIIVADPLIIETCKEVAPKLEIHLSTQQSLSNYKAVEYWKEEGLDRVVLARETGAMEMREMKEKVDIEIEAFIHGAMCIAYSGRCTLSNHMTARDSNRGGCCQSCRWDYELLEVDDNGELDVFYNQGEVTPFAMSPKDLKLIESIPQMMDIGVDSLKIEGRMKSIHYIATVVSVYRKVIDAYAADPDNFKINPEWLIELDKCANRDTAPAFFEGTPGYEEQMFGQQQSKKSPFDFCGLVLDYNEDTKIATIQQRNNFKPGQEIEFFGPEIETFTQVVEAIYDEEGNSLDAARHPLQIVQIKVDRPIYPNNMMRKEIG
>NZ_CP022718.1|WP_000648617.1|1641694_1642318_-|uridine-kinase
MKATTIIGIAGGSGSGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTKKYADIIIPEGGSNKVAIDIMTTKIQSLVSKQ
>NZ_CP022718.1|WP_000066097.1|1653224_1654343_-|tRNA-2-thiouridine(34)-synthase-MnmA
MSNKDIRVVVGMSGGVDSSVTAHVLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKEYWDKVFTYFLDEYKKGRTPNPDVMCNKEIKFKAFLDHAMNLGADYVATGHYARIHRHEDGHVEMLRGVDNNKDQTYFLNQLSQQQLSKVMFPIGDIEKSEVRRIAEEQGLVTAKKKDSTGICFIGEKNFKTFLSQYLPAQPGDMITLDGKKMGKHSGLMYYTIGQRHGLGIGGDGDPWFVVGKNLKDNVLYVEQGFHHDALYSDYLIASDYSFVNPEDNDLDQGFECTAKFRYRQKDTKVFVKRENDHALRVTFAEPVRAITPGQAVVFYQGDVCLGGATIDDVFKNEGQLNYVV
>NZ_CP022718.1|WP_000409174.1|1654343_1655486_-|cysteine-desulfurase
MEIYADYAATTPVKPEVVDAMMTIYNSHYGNPSSIHAKGRDARKYLDESRRQIAQLLGADTHEIIFTSGATESNNTAIKGIVKANEQLGNHIITSKIEHHSVLNVFEQLEREGFDVTYLDVDDTGAIDLDQLEETITDKTILVSIMFVNNEVGTVQQIYDIQDIIAETNAYFHVDAVQAIGHLDVKFDEFEIDAMSITAHKFGGPKGVGALLVKDHVTLDYPQLGGEQELKRRAGTENLAQIVGMAKALQLAEKNRDDNNIHLMNLKEQFLVKLQERAIPFELNGSMTDATGHIVNLYFPFVEVETMLTLLDMAQIYVSSGSACTAGSTQPSHVLDAMFEDEERSNHSIRFSFNELTTENEINAIVAEIHKIYFKFKEES
>NZ_CP022718.1|WP_000985872.1|1655797_1656811_+|LLM-class-flavin-dependent-oxidoreductase
MAIKYSALNLVPIREGDDEQTAINDMVNLAQHLDELSYERYWIAEHHNAPNLVSSATALLIQHTLEHTKHIRVGSGGIMLPNHAPLIVAEQFGTMATLFPNRVDLGLGRAPGTDMMTASALRRDQHDGVYKFPEEVSLLQQYFGPAHQQAYVRAYPAVGKNVPLYILGSSTDSAHLAARKGLPYVFAGHFAPQQMKEAIEIYKTLFEPSDVLDEPYVIVCLNTIVAENDDEAQYLASSMAQVMVSITRGRMQPVQPPTHELQNILTPREYAMAMERQKISLIGSENTVQQKIQDFMETYGEVNEIMAISYIYDKDMQLDSYRRFKNVINQINEKNTL
>NZ_CP022718.1|WP_000009238.1|1657047_1657194_-|hypothetical-protein
MSFMDKAKDAVEKFKNSDNEQVKNVKDKINEYTGSNNEEKKENEDKEK
>NZ_CP022718.1|WP_000752909.1|1657233_1657416_-|CsbD-family-protein
MADESKFDQFKGNVKETVGNVTDNKELEKEGQQDKATGKAKEVVENAKNKITDAIDKLKK
>NZ_CP022718.1|WP_000704122.1|1657515_1657938_-|Rrf2-family-transcriptional-regulator
MKISTKGRYGLTLMISLAKKEGQGCISLKSIAEENNLSDLYLEQLVGPLRNAGLIRSVRGAKGGYQLRVPAEEISAGDIIRLLEGPITFVESIESEPPAQKQLWIRMRDAVRDVLDNTTLKYLAEYVDTSEDLDGYMFYI
>NZ_CP022718.1|WP_000102740.1|1658022_1659297_+|replication-associated-recombination-protein-A
MSTEPLASRMRPKNIDEIISQQHLVGPRGIIRRMVDTKKLTSMIFYGPPGIGKTSIAKAISGSTQYKFRQLNAVTNTKKDMQLVVEEAKMSGQVILLLDEIHRLDKAKQDFLLPHLENGKIVLIGATTSNPYHAINPAIRSRAQIFELYPLNDEDVRQALTRAIEDEENGLKTYQPKIDEDAMTYFSTQSQGDVRSALNALELAVLSADNDKDGYRHVTLQDAKDCLQKGAFVSDKDGDMHYDVMSAFQKSIRGSDVNAALHYLARLIEAGDLPTIVRRLLVISYEDIGLASPNAGQRTLAAIESAERLGLPEARIPLSQAVIELCLSPKSNSAMSAIDSALSDIRNGHVGQIPNHLKDGHYQGAKDLGRSIGYKYPHQYVNGYVSQQYLPDKLKNKIYYEPKTTSKSEQQLKEIYNNLLKQRP
>NZ_CP022718.1|WP_000682646.1|1659457_1660231_-|tRNA-threonylcarbamoyladenosine-dehydratase
MKHQFSRNELAIGQQGLDLLKQQTVVILGVGGVGSFAAEALARTNIGHIILIDKDDVDITNVNRQLHALTTTVGQSKVSLMEERIKLINPDCKVTPLHMFYTEETYEEIFDNYDIDYFVDASDTIMYKVHLMKECLDRGIKVISSMGAANKTDPTRFTISDISKTHTDPMAKIIRQKLKKLGIRKGIPVVFSDESPIVIREDVKDIVGDKNAINRKGQMPPSSNAFVPSVVGLICASYVVNDVLKDIPVRRIKDKGQ
>NZ_CP022718.1|WP_001808243.1|1660230_1660359_-|hypothetical-protein
MGLIAFNKCFLVEFWENNQSDNAKYKILSYYVLMYKSVKEVK
>NZ_CP022718.1|WP_000044799.1|1660691_1662458_-|aspartate--tRNA-ligase
MSKRTTYCGLVTEAFLGQEITLKGWVNNRRDLGGLIFVDLRDREGIVQVVFNPAFSEEALKIAETVRSEYVVEVQGTVTKRDPETVNPKIKTGQVEVQVTNIKVINKSETPPFSINEENVNVDENIRLKYRYLDLRRQELAQTFKMRHQITRSIRQYLDDEGFFDIETPVLTKSTPEGARDYLVPSRVHDGEFYALPQSPQLFKQLLMISGFDKYYQIVKCFRDEDLRADRQPEFTQVDIEMSFVDQEDVMQMGEEMLKKVVKEVKGVEINGAFPRMTYKEAMRRYGSDKPDTRFEMELIDVSQLGRDMDFKVFKDTVENDGEIKAIVAKGAAEQYTRKDMDALTEFVNIYGAKGLAWVKVVEDGLTGPIGRFFETENVETLLTLTGAEAGDLVMFVADKPNVVAQSLGALRVKLAKELGLIDETKLNFLWVTDWPLLEYDEDAKRYVAAHHPFTSPKEADIAKLGTAPEEAEANAYDIVLNGYELGGGSIRIHDGELQEKMFEVLGFTKEQAQEQFGFLLDAFKYGAPPHGGIALGLDRLVMLLTNRTNLRDTIAFPKTASATCLLTNAPGEVSDKQLEELSLRIRH

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Crispr_ID: NZ_CP022718_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022718_4

1739095-1739177

Orphan

Consensus_repeat	Method
ATGCAAGTTGGGGTGGGGCCCCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022718_4

>merge|NZ_CP022718|4|1739095-1739177|CRISPRCasFinder
ATGCAAGTTGGGGTGGGGCCCCAACACAGAGAATTTCGAAAAGAAATTCTACAGACCATGCAAGTTGGGGTGGGGCCCAACAT

>NZ_CP022718|4|4|1739095-1739177|CRISPRCasFinder
ATGCAAGTTGGGGTGGGGCCCCAACA	CAGAGAATTTCGAAAAGAAATTCTACAGACC
ATGCAAGTTGGGGTGGGGCCCAACAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022718.1\|WP_000840570.1\|1747163_1748111_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_CP022718.1\|WP_000626070.1\|1737878_1738820_-\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NZ_CP022718.1\|WP_000226923.1\|1734660_1737858_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_CP022718.1\|WP_000160435.1\|1739271_1740570_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NZ_CP022718.1\|WP_000040063.1\|1745873_1747076_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP022718.1\|WP_001232648.1\|1727969_1729727_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NZ_CP022718.1\|WP_000123164.1\|1723474_1724743_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NZ_CP022718.1\|WP_000634175.1\|1745127_1745628_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP022718.1\|WP_000689998.1\|1743868_1744987_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP022718.1\|WP_031775021.1\|1743631_1743745_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022718.1\|WP_000058385.1\|1732981_1734211_-\|NAD-dependent-malic-enzyme-4	unknown	unknown	gnl\|CDD\|235976
NZ_CP022718.1\|WP_000471569.1\|1731929_1732787_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_CP022718.1\|WP_000161676.1\|1742497_1743553_+\|aminopeptidase-P-family-protein	unknown	unknown	gnl\|CDD\|223085
NZ_CP022718.1\|WP_000777188.1\|1741633_1742323_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_CP022718.1\|WP_000818526.1\|1726260_1727622_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP022718.1\|WP_000829165.1\|1724791_1725913_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|184468
NZ_CP022718.1\|WP_000717561.1\|1729748_1730717_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP022718.1\|WP_000277602.1\|1740774_1741188_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP022718.1\|WP_000883645.1\|1730985_1731930_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_CP022718.1\|WP_000136257.1\|1748233_1748728_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055

Protein	Function_ID	Function_description	E-value
NZ_CP022718.1\|WP_000840570.1\|1747163_1748111_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	1.59776e-55
NZ_CP022718.1\|WP_000626070.1\|1737878_1738820_-\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	2.2886e-98
NZ_CP022718.1\|WP_000226923.1\|1734660_1737858_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_CP022718.1\|WP_000160435.1\|1739271_1740570_-\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NZ_CP022718.1\|WP_000040063.1\|1745873_1747076_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP022718.1\|WP_001232648.1\|1727969_1729727_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NZ_CP022718.1\|WP_000123164.1\|1723474_1724743_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP022718.1\|WP_000634175.1\|1745127_1745628_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
NZ_CP022718.1\|WP_000689998.1\|1743868_1744987_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP022718.1\|WP_000058385.1\|1732981_1734211_-\|NAD-dependent-malic-enzyme-4	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_CP022718.1\|WP_000471569.1\|1731929_1732787_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_CP022718.1\|WP_000161676.1\|1742497_1743553_+\|aminopeptidase-P-family-protein	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	7.02579e-126
NZ_CP022718.1\|WP_000777188.1\|1741633_1742323_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	3.09103e-133
NZ_CP022718.1\|WP_000818526.1\|1726260_1727622_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP022718.1\|WP_000829165.1\|1724791_1725913_-\|citrate-synthase	gnl\|CDD\|184468	PRK14035, PRK14035, citrate synthase; Provisional.	0
NZ_CP022718.1\|WP_000717561.1\|1729748_1730717_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NZ_CP022718.1\|WP_000277602.1\|1740774_1741188_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
NZ_CP022718.1\|WP_000883645.1\|1730985_1731930_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_CP022718.1\|WP_000136257.1\|1748233_1748728_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	5.93419e-100

>NZ_CP022718.1|WP_000626070.1|1737878_1738820_-|pApA-hydrolase-Pde2
MISTLNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGRKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLEQFGIHPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVDSWDEFEQLATALRTKLN
>NZ_CP022718.1|WP_000226923.1|1734660_1737858_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTVETVVLVKNNDGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKKVGDQHRDIVQVFETHNDIYMDHLSISIQGRKHVWIQDVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEIKQLDINQEYLTQVDVIAQKCNAELKYHQSLLPQYETPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKYKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVILNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVMLSFYDETIKQMTTIGYINQKDSMFNNFIQSFNPSDIRLI
>NZ_CP022718.1|WP_000058385.1|1732981_1734211_-|NAD-dependent-malic-enzyme-4
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTMAGLVNALRVINKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NZ_CP022718.1|WP_000471569.1|1731929_1732787_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLERHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NZ_CP022718.1|WP_000883645.1|1730985_1731930_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVAQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NZ_CP022718.1|WP_000717561.1|1729748_1730717_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NZ_CP022718.1|WP_001232648.1|1727969_1729727_-|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVSNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NZ_CP022718.1|WP_000818526.1|1726260_1727622_+|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAVKSNK
>NZ_CP022718.1|WP_000829165.1|1724791_1725913_-|citrate-synthase
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKDPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDAYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>NZ_CP022718.1|WP_000123164.1|1723474_1724743_-|NADP-dependent-isocitrate-dehydrogenase
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALSEFGDQVFTWQQYDEIVEKEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK
>NZ_CP022718.1|WP_000160435.1|1739271_1740570_-|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVINFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANRTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NZ_CP022718.1|WP_000277602.1|1740774_1741188_+|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NZ_CP022718.1|WP_000777188.1|1741633_1742323_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NZ_CP022718.1|WP_000161676.1|1742497_1743553_+|aminopeptidase-P-family-protein
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLTSGFNVNSFGDVDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGNRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPSKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK
>NZ_CP022718.1|WP_031775021.1|1743631_1743745_-|hypothetical-protein
MNDIDLIHYMLLMNIPAYVFLACLLHIAFRLGQKFMS
>NZ_CP022718.1|WP_000689998.1|1743868_1744987_-|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NZ_CP022718.1|WP_000634175.1|1745127_1745628_+|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>NZ_CP022718.1|WP_000040063.1|1745873_1747076_-|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLIERIGLKDSIFTIEVNGEKVKTVQDIKDHVEAVDIMLDAFKAHNIINDINDIDGTGHRVVHGGEKFPESVAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLLRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTFGGLK
>NZ_CP022718.1|WP_000840570.1|1747163_1748111_-|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNDRGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMSLPLEEADIVIGDFPVGYYPIDERSKEFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NZ_CP022718.1|WP_000136257.1|1748233_1748728_-|thiol-peroxidase
MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI

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Crispr_ID: NZ_CP022718_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022718_5

2403465-2403562

Orphan

Consensus_repeat	Method
TTTCTGCGAATTTTATGAGCTAGAAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022718_5

>merge|NZ_CP022718|5|2403465-2403562|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCATTAGTAGCGAAGCTAACTAATGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGC

>NZ_CP022718|5|5|2403465-2403562|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGC	TTATGCATTAGTAGCGAAGCTAACTAATGCGTTCCTTTAT
TTTCTGCGAATTTTATGAGCTAGAAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022718.1\|WP_000200945.1\|2409277_2409745_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NZ_CP022718.1\|WP_001125208.1\|2401445_2402132_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
NZ_CP022718.1\|WP_000615461.1\|2397246_2397978_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP022718.1\|WP_000162810.1\|2394664_2395264_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NZ_CP022718.1\|WP_000019127.1\|2402458_2403325_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP022718.1\|WP_000819843.1\|2395282_2395645_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
NZ_CP022718.1\|WP_000971546.1\|2410458_2411574_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NZ_CP022718.1\|WP_000038960.1\|2399574_2401014_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NZ_CP022718.1\|WP_000594519.1\|2405803_2406733_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NZ_CP022718.1\|WP_001789199.1\|2403740_2403860_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022718.1\|WP_001012222.1\|2395899_2397150_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NZ_CP022718.1\|WP_000762708.1\|2401187_2401292_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NZ_CP022718.1\|WP_000916704.1\|2407299_2408247_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
NZ_CP022718.1\|WP_000783428.1\|2408248_2409226_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NZ_CP022718.1\|WP_001046645.1\|2411551_2412559_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_CP022718.1\|WP_000825929.1\|2398674_2399454_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NZ_CP022718.1\|WP_115304444.1\|2412560_2413919_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_CP022718.1\|WP_115304443.1\|2403954_2405268_+\|immunoglobulin-binding-protein-sbi	unknown	unknown	gnl\|CDD\|288473
NZ_CP022718.1\|WP_000479576.1\|2397974_2398694_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP022718.1\|WP_000286876.1\|2409755_2410448_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342

Protein	Function_ID	Function_description	E-value
NZ_CP022718.1\|WP_000200945.1\|2409277_2409745_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.000705213
NZ_CP022718.1\|WP_001125208.1\|2401445_2402132_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
NZ_CP022718.1\|WP_000615461.1\|2397246_2397978_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.20826e-144
NZ_CP022718.1\|WP_000162810.1\|2394664_2395264_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	1.74649e-30
NZ_CP022718.1\|WP_000019127.1\|2402458_2403325_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.54055e-90
NZ_CP022718.1\|WP_000819843.1\|2395282_2395645_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.11961e-31
NZ_CP022718.1\|WP_000971546.1\|2410458_2411574_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	1.99808e-138
NZ_CP022718.1\|WP_000038960.1\|2399574_2401014_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.41176e-92
NZ_CP022718.1\|WP_000594519.1\|2405803_2406733_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.31899e-97
NZ_CP022718.1\|WP_001012222.1\|2395899_2397150_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NZ_CP022718.1\|WP_000916704.1\|2407299_2408247_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.97441e-93
NZ_CP022718.1\|WP_000783428.1\|2408248_2409226_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
NZ_CP022718.1\|WP_001046645.1\|2411551_2412559_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_CP022718.1\|WP_000825929.1\|2398674_2399454_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.20682e-100
NZ_CP022718.1\|WP_115304444.1\|2412560_2413919_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_CP022718.1\|WP_115304443.1\|2403954_2405268_+\|immunoglobulin-binding-protein-sbi	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	4.53353e-27
NZ_CP022718.1\|WP_000479576.1\|2397974_2398694_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.98247e-78
NZ_CP022718.1\|WP_000286876.1\|2409755_2410448_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	1.16849e-130

>NZ_CP022718.1|WP_000019127.1|2402458_2403325_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNAPRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NZ_CP022718.1|WP_001125208.1|2401445_2402132_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NZ_CP022718.1|WP_000762708.1|2401187_2401292_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NZ_CP022718.1|WP_000038960.1|2399574_2401014_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>NZ_CP022718.1|WP_000825929.1|2398674_2399454_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVMIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKADDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NZ_CP022718.1|WP_000479576.1|2397974_2398694_-|amino-acid-ABC-transporter-permease
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NZ_CP022718.1|WP_000615461.1|2397246_2397978_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELRRFLNVINEE
>NZ_CP022718.1|WP_001012222.1|2395899_2397150_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDKLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVQTYLNHKRR
>NZ_CP022718.1|WP_000819843.1|2395282_2395645_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYDFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>NZ_CP022718.1|WP_000162810.1|2394664_2395264_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDNHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NZ_CP022718.1|WP_001789199.1|2403740_2403860_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYGEMQYFANK
>NZ_CP022718.1|WP_115304443.1|2403954_2405268_+|immunoglobulin-binding-protein-sbi
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNVKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYYNKYYQYKGLIDQTVLTTIGSGYGSYIKPLEVSKESGNLAKSYAQVRNYVTESINTSKVLYAFYQKPELVKTAIKAQETATTFKNALTGIFKSFWK
>NZ_CP022718.1|WP_000594519.1|2405803_2406733_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NZ_CP022718.1|WP_000916704.1|2407299_2408247_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>NZ_CP022718.1|WP_000783428.1|2408248_2409226_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NZ_CP022718.1|WP_000200945.1|2409277_2409745_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSLLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NZ_CP022718.1|WP_000286876.1|2409755_2410448_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFAAAKIGYHRLFDIKPVNTRYGGRIIFVDNRIDLNHYISFLESTPKQVVYETV
>NZ_CP022718.1|WP_000971546.1|2410458_2411574_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDIDRLFEILHQED
>NZ_CP022718.1|WP_001046645.1|2411551_2412559_-|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN
>NZ_CP022718.1|WP_115304444.1|2412560_2413919_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGVVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRKCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	1092617-1092645	0	1.0
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	2689281-2689309	0	1.0
NZ_CP022718_2	2.1\|780734\|32\|NZ_CP022718\|CRISPRCasFinder	780734-780765	32	NZ_CP022718.1	1022031-1022062	0	1.0
NZ_CP022718_2	2.1\|780734\|32\|NZ_CP022718\|CRISPRCasFinder	780734-780765	32	NZ_CP022718.1	1305255-1305286	0	1.0
NZ_CP022718_2	2.1\|780734\|32\|NZ_CP022718\|CRISPRCasFinder	780734-780765	32	NZ_CP022718.1	1392962-1392993	0	1.0
NZ_CP022718_2	2.1\|780734\|32\|NZ_CP022718\|CRISPRCasFinder	780734-780765	32	NZ_CP022718.1	1945405-1945436	0	1.0
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	249159-249187	1	0.966
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	331567-331595	1	0.966
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	331622-331650	1	0.966
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	1620361-1620389	1	0.966
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	1741402-1741430	1	0.966
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	1796596-1796624	1	0.966
NZ_CP022718_2	2.1\|780734\|32\|NZ_CP022718\|CRISPRCasFinder	780734-780765	32	NZ_CP022718.1	1652925-1652956	1	0.969
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	129752-129780	2	0.931
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	129810-129838	2	0.931
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	995474-995502	2	0.931
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	1180859-1180887	2	0.931
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	1954813-1954841	2	0.931
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	2253166-2253194	2	0.931
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	2444208-2444236	2	0.931
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	NZ_CP022718.1	2444266-2444294	2	0.931
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	233994-234025	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	331450-331481	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	995532-995563	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	995648-995679	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	1096809-1096840	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	1180797-1180828	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	1305313-1305344	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	1392904-1392935	2	0.938
NZ_CP022718_3	3.1\|1652984\|32\|NZ_CP022718\|CRISPRCasFinder	1652984-1653015	32	NZ_CP022718.1	1796707-1796738	2	0.938

1. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 1092617-1092645, mismatch: 0, identity: 1.0

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtagaatttcttttcgaaa	Protospacer
*****************************

2. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 2689281-2689309, mismatch: 0, identity: 1.0

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtagaatttcttttcgaaa	Protospacer
*****************************

3. spacer 2.1|780734|32|NZ_CP022718|CRISPRCasFinder matches to position: 1022031-1022062, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

4. spacer 2.1|780734|32|NZ_CP022718|CRISPRCasFinder matches to position: 1305255-1305286, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

5. spacer 2.1|780734|32|NZ_CP022718|CRISPRCasFinder matches to position: 1392962-1392993, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

6. spacer 2.1|780734|32|NZ_CP022718|CRISPRCasFinder matches to position: 1945405-1945436, mismatch: 0, identity: 1.0

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttcttttcgaaattc	Protospacer
********************************

7. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 249159-249187, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

8. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 331567-331595, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcttgtagaatttcttttcgaaa	Protospacer
*******.*********************

9. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 331622-331650, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcttgtagaatttcttttcgaaa	Protospacer
*******.*********************

10. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 1620361-1620389, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

11. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 1741402-1741430, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

12. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 1796596-1796624, mismatch: 1, identity: 0.966

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaa	Protospacer
********.********************

13. spacer 2.1|780734|32|NZ_CP022718|CRISPRCasFinder matches to position: 1652925-1652956, mismatch: 1, identity: 0.969

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
cgcattgcctgtagaatttctttacgaaattc	Protospacer
*********************** ********

14. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 129752-129780, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

15. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 129810-129838, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

16. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 995474-995502, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

17. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 1180859-1180887, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

18. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 1954813-1954841, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttcctttcgaaa	Protospacer
********.***********.********

19. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 2253166-2253194, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtctgtagaatttctttttgaaa	Protospacer
********.***************.****

20. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 2444208-2444236, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

21. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to position: 2444266-2444294, mismatch: 2, identity: 0.931

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaa	Protospacer
*******..********************

22. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 233994-234025, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

23. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 331450-331481, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

24. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 995532-995563, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

25. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 995648-995679, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

26. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 1096809-1096840, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

27. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 1180797-1180828, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

28. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 1305313-1305344, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

29. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 1392904-1392935, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgtaagctgacttttcgtcagct	Protospacer
*********** ************ *******

30. spacer 3.1|1652984|32|NZ_CP022718|CRISPRCasFinder matches to position: 1796707-1796738, mismatch: 2, identity: 0.938

gcacattattgaaagctgacttttggtcagct	CRISPR spacer
gcacattattgaaagctgactattggccagct	Protospacer
********************* ****.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022718_1	1.1\|775241\|29\|NZ_CP022718\|CRISPRCasFinder	775241-775269	29	MN693281	Marine virus AFVG_25M371, complete genome	6448-6476	7	0.759
NZ_CP022718_2	2.1\|780734\|32\|NZ_CP022718\|CRISPRCasFinder	780734-780765	32	NZ_CP009619	Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence	270872-270903	8	0.75
NZ_CP022718_4	4.1\|1739121\|31\|NZ_CP022718\|CRISPRCasFinder	1739121-1739151	31	KM359505	Prochlorococcus phage P-TIM68, complete genome	102706-102736	8	0.742

1. spacer 1.1|775241|29|NZ_CP022718|CRISPRCasFinder matches to MN693281 (Marine virus AFVG_25M371, complete genome) position: , mismatch: 7, identity: 0.759

tgcattgtttgtagaatttcttttcgaaa	CRISPR spacer
tgcattgtttgtaggatttcttctaagtg	Protospacer
**************.*******.* .. .

2. spacer 2.1|780734|32|NZ_CP022718|CRISPRCasFinder matches to NZ_CP009619 (Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence) position: , mismatch: 8, identity: 0.75

cgcattgcctgtagaatttcttttcgaaattc	CRISPR spacer
tgcattacctgtagcatttcttttttcaacta	Protospacer
.*****.******* *********.  **.*

3. spacer 4.1|1739121|31|NZ_CP022718|CRISPRCasFinder matches to KM359505 (Prochlorococcus phage P-TIM68, complete genome) position: , mismatch: 8, identity: 0.742

cagagaatttcgaaaagaaattctacagacc	CRISPR spacer
ttaactatttccaaaagaaattatacagatc	Protospacer
. .*  ***** ********** ******.*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

712438 : 720258

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|712438_713494_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|713493_714180_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037807.1\|714154_714628_-	DoxX family protein	NA	NA	NA	NA
WP_001093561.1\|714969_715410_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637687.1\|715689_716274_-	hypothetical protein	NA	NA	NA	NA
WP_001062972.1\|716372_717086_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|717089_717509_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|717510_718179_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000604515.1\|718529_719123_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.2e-38	43.5
WP_001217794.1\|719106_720258_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	3.5e-23	36.1

DBSCAN-SWA_2

732229 : 746848

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000663026.1\|732229_733288_+	histidinol-phosphate transaminase	A0A0H3TLT9	Faustovirus	1.5e-20	27.3
WP_000197275.1\|733638_734181_+	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000429006.1\|734804_735722_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.0
WP_031835073.1\|735812_735914_+	hypothetical protein	NA	NA	NA	NA
WP_000193751.1\|735991_737497_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_000930014.1\|737837_738338_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_001068497.1\|738357_739224_-	DMT family transporter	NA	NA	NA	NA
WP_000692521.1\|740024_740423_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|740385_742491_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|742608_743580_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000499195.1\|743981_744137_+	hypothetical protein	NA	NA	NA	NA
WP_000876318.1\|744175_745147_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_001245577.1\|745133_746090_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000616842.1\|746086_746848_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	8.5e-18	31.6

DBSCAN-SWA_3

921275 : 976983

Streptococcus_phage(28.57%)

transposase,tRNA,protease,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000448934.1\|921275_922265_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|922559_922955_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_115304429.1\|923018_924665_-\|transposase	IS1182 family transposase	A0ZS58	Staphylococcus_virus	6.1e-287	97.3
WP_001217728.1\|925245_925965_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959289.1\|926085_927072_+	competence protein CoiA	NA	NA	NA	NA
WP_000082725.1\|927119_928928_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	5.5e-47	24.5
WP_115304430.1\|929387_930194_-	DsbA family protein	NA	NA	NA	NA
WP_000214069.1\|930216_930582_-	hypothetical protein	NA	NA	NA	NA
WP_000224619.1\|930685_931279_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242102.1\|931464_931812_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|931828_932464_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|932480_933290_+	NAD kinase	NA	NA	NA	NA
WP_000669923.1\|933286_934141_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062407.1\|934161_935547_+	magnesium transporter	NA	NA	NA	NA
WP_000395152.1\|935556_937401_+	sodium:proton antiporter	NA	NA	NA	NA
WP_000933195.1\|937678_938449_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|938644_939730_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570700.1\|940070_941639_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_000889191.1\|941783_942542_+	esterase family protein	NA	NA	NA	NA
WP_000600387.1\|942735_943245_+	hypothetical protein	NA	NA	NA	NA
WP_001794241.1\|943357_944566_-	MFS transporter	NA	NA	NA	NA
WP_000258650.1\|944525_945701_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340119.1\|946133_947618_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_001795833.1\|947598_947859_+	hypothetical protein	NA	NA	NA	NA
WP_001049951.1\|947858_949421_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	1.7e-36	28.2
WP_000928413.1\|949722_950526_+	TerC family protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
WP_000455278.1\|950744_953069_+\|protease	serine protease	W5SAB9	Pithovirus	2.8e-11	27.4
WP_000021865.1\|953085_954444_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414185.1\|954582_956094_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|956580_957150_-	competence protein ComK	NA	NA	NA	NA
WP_000876826.1\|957359_957578_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668818.1\|957658_958645_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|958843_959020_+	YkvS family protein	NA	NA	NA	NA
WP_001033865.1\|959034_959637_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_031763719.1\|960552_960654_+	hypothetical protein	NA	NA	NA	NA
WP_001797239.1\|960663_960936_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000870832.1\|960979_962944_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA
WP_000668627.1\|962946_963267_+	YxeA family protein	NA	NA	NA	NA
WP_000571167.1\|963263_963905_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-19	33.0
WP_072361064.1\|963992_964283_-	hypothetical protein	NA	NA	NA	NA
WP_000410720.1\|964561_964849_+	hypothetical protein	NA	NA	NA	NA
WP_000719184.1\|964854_966336_+	glycosyltransferase	NA	NA	NA	NA
WP_000766009.1\|966424_966781_-	DoxX family protein	NA	NA	NA	NA
WP_001081344.1\|967268_968228_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_020978112.1\|968273_968405_-	hypothetical protein	NA	NA	NA	NA
WP_001788574.1\|968468_968759_-	TM2 domain-containing protein	A0A060AN66	Enterococcus_phage	7.5e-07	38.0
WP_000620949.1\|968848_969400_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_103151798.1\|969451_970390_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_001791731.1\|970540_970645_+	hypothetical protein	NA	NA	NA	NA
WP_072399156.1\|970721_971933_+	isochorismate synthase	NA	NA	NA	NA
WP_000526685.1\|971919_973593_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase	NA	NA	NA	NA
WP_000150223.1\|973579_974383_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
WP_000184947.1\|974375_975197_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
WP_000284457.1\|975434_975764_-	staphostatin B	NA	NA	NA	NA
WP_001089097.1\|975801_976983_-\|protease	cysteine protease staphopain B	NA	NA	NA	NA

DBSCAN-SWA_4

997156 : 1005629

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000861572.1\|997156_997639_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
WP_001010414.1\|997625_998750_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174044.1\|998753_999458_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	8.1e-47	41.6
WP_000848350.1\|999457_999721_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666806.1\|999722_1000394_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032733.1\|1000386_1002576_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.7e-141	39.8
WP_000483713.1\|1002554_1004039_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.2e-45	31.7
WP_115304431.1\|1004031_1005060_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.5e-62	41.7
WP_000238675.1\|1005062_1005629_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.2e-30	40.7

DBSCAN-SWA_5

1446254 : 1533144

Staphylococcus_phage(70.27%)

capsid,terminase,portal,tail,tRNA,holin,plate,head,protease,integrase

attL 1485939:1485956|attR 1531661:1531678

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858791.1\|1446254_1447547_-\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.9e-54	30.0
WP_000525074.1\|1447868_1450562_-	ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
WP_000049921.1\|1450585_1451557_-	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000361532.1\|1451543_1452746_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	1.2e-34	42.0
WP_000690027.1\|1452750_1453893_-	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000839931.1\|1454133_1454451_-	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_001827022.1\|1454787_1455468_-	zinc metallopeptidase	NA	NA	NA	NA
WP_000152734.1\|1455539_1456127_-	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_000005213.1\|1456116_1456692_-	IDEAL domain-containing protein	G3MAV7	Bacillus_virus	2.7e-08	27.2
WP_011443634.1\|1456705_1457809_-	hypothetical protein	NA	NA	NA	NA
WP_000245900.1\|1457956_1459255_-	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000776326.1\|1459264_1460329_-	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269929.1\|1460354_1461521_-	chorismate synthase	A0A291AU41	Pandoravirus	7.6e-34	32.1
WP_000789522.1\|1461906_1462107_-	hypothetical protein	NA	NA	NA	NA
WP_000442480.1\|1462315_1462765_-	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_016169114.1\|1462856_1463801_-	heptaprenyl diphosphate synthase component II	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000774684.1\|1463817_1464543_-	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_000450555.1\|1464545_1465118_-	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_001043863.1\|1465548_1465821_-	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000161746.1\|1465991_1466990_-	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_000165533.1\|1467006_1468317_-	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000133950.1\|1468538_1469714_-	30S ribosomal protein S1	NA	NA	NA	NA
WP_000644391.1\|1470411_1471071_-	(d)CMP kinase	NA	NA	NA	NA
WP_000681769.1\|1471147_1472116_+	asparaginase	NA	NA	NA	NA
WP_001174260.1\|1472230_1473217_-	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_031824588.1\|1473377_1473494_-	hypothetical protein	NA	NA	NA	NA
WP_000069314.1\|1473618_1475073_-	elastin-binding protein EbpS	NA	NA	NA	NA
WP_000902122.1\|1475225_1476605_-	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	3.8e-56	33.3
WP_001163805.1\|1476594_1477548_-	hypothetical protein	NA	NA	NA	NA
WP_001151997.1\|1477655_1477904_+	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001186912.1\|1478009_1478555_-	ECF transporter S component	NA	NA	NA	NA
WP_000476341.1\|1478956_1479889_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000476338.1\|1479945_1480863_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000476867.1\|1480920_1481826_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_078064398.1\|1481916_1482279_-	hypothetical protein	Q4ZCJ7	Staphylococcus_virus	3.4e-25	100.0
WP_000909210.1\|1483952_1485407_-	CHAP domain-containing protein	Q8SDN4	Staphylococcus_virus	7.5e-289	99.8
WP_000339144.1\|1485417_1485720_-\|holin	phage holin	B7T0L0	Staphylococcus_virus	4.1e-48	100.0
WP_000466784.1\|1485855_1486155_-	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
1485939:1485956	attL	NA	NA	NA	NA
WP_000916020.1\|1486200_1486365_-	XkdX family protein	A0A2I6PES4	Staphylococcus_phage	4.9e-24	100.0
WP_001166599.1\|1486357_1486747_-	DUF2977 domain-containing protein	A0A2I6PER1	Staphylococcus_phage	2.2e-62	100.0
WP_000067148.1\|1486746_1488213_-\|plate	BppU family phage baseplate upper protein	Q8SDN8	Staphylococcus_virus	3.4e-257	100.0
WP_000429551.1\|1488212_1490123_-	minor structural protein	A0A2I6PF35	Staphylococcus_phage	0.0e+00	100.0
WP_000179862.1\|1490138_1490429_-	hypothetical protein	Q8SDP0	Staphylococcus_virus	2.1e-49	100.0
WP_000384462.1\|1490428_1492012_-	peptidase	Q8SDP1	Staphylococcus_virus	7.1e-309	100.0
WP_001190533.1\|1492020_1492845_-\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_000438833.1\|1499057_1499216_-	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_000589165.1\|1499257_1499608_-	hypothetical protein	A0A2I6PDE6	Staphylococcus_phage	1.1e-55	100.0
WP_000169128.1\|1499665_1500121_-	Ig domain-containing protein	A0A2I6PF45	Staphylococcus_phage	1.3e-77	100.0
WP_000807536.1\|1500212_1500854_-\|tail	tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
WP_001023802.1\|1500888_1501284_-	DUF3168 domain-containing protein	A0A2I6PDD8	Staphylococcus_phage	2.6e-66	100.0
WP_000110020.1\|1501284_1501686_-	hypothetical protein	A0A2I6PDD3	Staphylococcus_phage	6.2e-68	100.0
WP_000395501.1\|1501682_1502015_-	hypothetical protein	A0A2I6PDD6	Staphylococcus_phage	6.2e-58	100.0
WP_000050973.1\|1502026_1502305_-\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_001142739.1\|1502373_1503537_-\|capsid	phage major capsid protein	A0A2I6PDD7	Staphylococcus_phage	9.4e-218	100.0
WP_000061872.1\|1503548_1504322_-\|protease	Clp protease ClpP	M1TAZ4	Staphylococcus_phage	9.2e-137	100.0
WP_001100669.1\|1504305_1505544_-\|portal	phage portal protein	A0A2K9VBP0	Staphylococcus_phage	6.9e-235	100.0
WP_043054673.1\|1505548_1507240_-\|terminase	terminase large subunit	A0A2I6PE44	Staphylococcus_phage	0.0e+00	99.8
WP_000778932.1\|1507229_1507535_-\|terminase	terminase	A0A2I6PE27	Staphylococcus_phage	2.9e-49	100.0
WP_000160689.1\|1507663_1507978_-	HNH endonuclease	A0A2I6PDC4	Staphylococcus_phage	2.5e-56	100.0
WP_000513703.1\|1508134_1508572_-	transcriptional regulator	A0A2K9VBV2	Staphylococcus_phage	7.9e-77	99.3
WP_001795330.1\|1508584_1509952_-	DEAD/DEAH box helicase	Q4ZCF6	Staphylococcus_virus	4.6e-264	100.0
WP_000665203.1\|1509932_1510223_-	VRR-NUC domain-containing protein	A0A2I6PEN7	Staphylococcus_phage	6.5e-51	100.0
WP_011447017.1\|1510356_1510461_+	hypothetical protein	Q4ZCF8	Staphylococcus_virus	9.4e-13	100.0
WP_000884854.1\|1510563_1513011_-	hypothetical protein	Q4ZCG0	Staphylococcus_virus	0.0e+00	100.0
WP_000265258.1\|1513062_1513263_-	DUF1514 family protein	A0A2I6PF41	Staphylococcus_phage	2.9e-26	100.0
WP_000595260.1\|1513330_1513483_-	transcriptional activator RinB	A7TWI2	Staphylococcus_phage	2.6e-19	100.0
WP_000195820.1\|1513479_1513686_-	DUF1381 domain-containing protein	A0A1X9H0C2	Staphylococcus_phage	1.3e-21	100.0
WP_001066444.1\|1513722_1514259_-	hypothetical protein	A0A1X9H0S5	Staphylococcus_phage	1.4e-96	100.0
WP_000197967.1\|1514251_1514662_-	hypothetical protein	C8CH13	Staphylococcus_phage	2.3e-70	100.0
WP_031868690.1\|1514658_1515192_-	hypothetical protein	A0A1X9H0D4	Staphylococcus_phage	8.5e-81	96.1
WP_000979209.1\|1515188_1515536_-	hypothetical protein	D2JGL4	Staphylococcus_phage	5.9e-59	100.0
WP_000695759.1\|1515532_1515934_-	hypothetical protein	A0A0N7E0T5	Staphylococcus_phage	7.0e-72	100.0
WP_000693987.1\|1515936_1516143_-	hypothetical protein	A0A0N9BAW9	Staphylococcus_phage	3.0e-34	100.0
WP_015968801.1\|1516156_1516405_-	PVL orf 51-like protein	Q8SDR2	Staphylococcus_virus	1.8e-41	100.0
WP_000235381.1\|1516413_1516614_-	hypothetical protein	A0A2I6PF32	Staphylococcus_phage	1.3e-29	100.0
WP_000111488.1\|1516616_1516874_-	DUF3310 domain-containing protein	A0A2I6PF10	Staphylococcus_phage	5.7e-43	100.0
WP_000113981.1\|1516873_1517275_-	PVL family protein	A0A2I6PF14	Staphylococcus_phage	1.2e-68	100.0
WP_001164629.1\|1517274_1517460_-	DUF3113 family protein	A0A2I6PEM8	Staphylococcus_phage	7.0e-27	100.0
WP_001796208.1\|1517472_1519425_-	DNA polymerase	A0A2I6PF18	Staphylococcus_phage	0.0e+00	100.0
WP_000645042.1\|1519493_1520051_-	DUF2815 family protein	A0A2I6PF05	Staphylococcus_phage	1.8e-97	100.0
WP_000762532.1\|1520076_1521243_-	DUF2800 domain-containing protein	A0A2I6PDL4	Staphylococcus_phage	8.3e-222	100.0
WP_000279445.1\|1521239_1521602_-	hypothetical protein	A0A2K9VBV1	Staphylococcus_phage	6.4e-56	100.0
WP_000175003.1\|1521616_1521940_-	hypothetical protein	A7TWG2	Staphylococcus_phage	2.5e-51	99.1
WP_000066008.1\|1522018_1522180_-	DUF1270 family protein	A0A2I6PDF7	Staphylococcus_phage	1.2e-19	96.2
WP_001124198.1\|1522191_1522455_-	helix-turn-helix domain-containing protein	A0A2I6PEL8	Staphylococcus_phage	2.5e-46	100.0
WP_001036303.1\|1522479_1522695_-	hypothetical protein	A0A2I6PDN5	Staphylococcus_phage	5.5e-31	95.8
WP_000549549.1\|1522750_1522981_+	hypothetical protein	A0A2I6PE22	Staphylococcus_phage	1.8e-35	97.4
WP_001115060.1\|1523242_1523434_-	helix-turn-helix transcriptional regulator	A0A2I6PEL6	Staphylococcus_phage	2.3e-28	100.0
WP_000429766.1\|1523594_1523924_+	helix-turn-helix transcriptional regulator	A0A2I6PEN2	Staphylococcus_phage	3.2e-54	100.0
WP_000524999.1\|1523936_1524398_+	hypothetical protein	A0A2I6PEK4	Staphylococcus_phage	3.7e-85	98.7
WP_000755721.1\|1524415_1524850_+	hypothetical protein	A0A2I6PEM0	Staphylococcus_phage	1.2e-24	100.0
WP_000449657.1\|1524878_1525274_+	hypothetical protein	A0A2I6PEJ7	Staphylococcus_phage	1.1e-69	99.2
WP_001013104.1\|1525363_1525510_+	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.1e-14	89.6
WP_000191458.1\|1525506_1526121_-	hypothetical protein	A7TW88	Staphylococcus_phage	8.8e-106	99.5
WP_000264751.1\|1526246_1527452_+\|integrase	site-specific integrase	A0A2I6PEN0	Staphylococcus_phage	7.7e-223	100.0
WP_001802420.1\|1527494_1529522_-	hypothetical protein	B5WZK7	Staphylococcus_phage	4.2e-112	95.8
WP_001641538.1\|1529533_1530442_-	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000987769.1\|1530686_1532438_-	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	1.7e-21	33.6
1531661:1531678	attR	NA	NA	NA	NA
WP_000064078.1\|1532418_1533144_-	response regulator transcription factor	W8CYM9	Bacillus_phage	3.5e-45	43.0

DBSCAN-SWA_6

1591965 : 1600295

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1591965_1592751_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924220.1\|1592876_1593767_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	3.4e-26	36.0
WP_001062183.1\|1593776_1595123_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	1.8e-55	34.0
WP_000683933.1\|1595236_1596337_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	5.2e-08	29.6
WP_000624583.1\|1596339_1597017_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1597147_1598254_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217252.1\|1598477_1600295_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.6e-54	36.0

DBSCAN-SWA_7

1668149 : 1677192

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1668149_1668668_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000594993.1\|1668689_1670963_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.2e-62	28.8
WP_000749789.1\|1671165_1673445_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1673719_1673980_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1673998_1675138_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019172.1\|1675160_1676186_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005769.1\|1676187_1677192_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_8

1801708 : 1874849

Staphylococcus_phage(94.12%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001641584.1\|1801708_1808269_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	1.3e-300	97.1
WP_000836465.1\|1808594_1808906_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.6e-52	100.0
WP_001108730.1\|1808927_1811342_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.5
WP_001025061.1\|1811632_1812814_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_000526539.1\|1812923_1813877_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_000764419.1\|1813873_1814437_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000757543.1\|1814556_1814958_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1815529_1816357_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_001790712.1\|1816359_1816479_-	hypothetical protein	NA	NA	NA	NA
WP_001196360.1\|1816590_1817592_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	7.7e-184	99.1
WP_001008551.1\|1817713_1818178_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_001175484.1\|1818190_1819372_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.5e-226	99.7
WP_000493886.1\|1819382_1820015_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	6.4e-112	99.0
WP_000384181.1\|1820021_1821053_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.8e-197	99.4
WP_001261679.1\|1821545_1823048_-	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	2.3e-30	100.0
WP_000221179.1\|1823570_1823885_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.0e-53	100.0
WP_000989121.1\|1823884_1825177_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
WP_000163236.1\|1825194_1825590_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	3.1e-72	99.2
WP_001032833.1\|1825884_1826739_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1827014_1827239_-	hypothetical protein	NA	NA	NA	NA
WP_000671057.1\|1827437_1827908_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	8.8e-82	98.1
WP_001153745.1\|1828020_1828464_+	competence protein ComK	NA	NA	NA	NA
WP_001030469.1\|1828450_1828894_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
WP_001168904.1\|1829189_1829825_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001096494.1\|1830264_1830978_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091445.1\|1831237_1831540_+	hypothetical protein	NA	NA	NA	NA
WP_001200542.1\|1831795_1832161_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
WP_000623471.1\|1832157_1832511_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	99.1
WP_000453317.1\|1834608_1835442_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	3.5e-158	99.6
WP_000366155.1\|1835653_1836562_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	1.7e-137	99.0
WP_000933822.1\|1836686_1837880_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109906.1\|1838251_1839844_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
WP_001834463.1\|1840221_1840968_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.4e-142	98.8
WP_000672015.1\|1840972_1841446_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	5.5e-84	99.4
WP_000718107.1\|1841511_1841769_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778538.1\|1841765_1842767_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	9.0e-185	97.0
WP_000348365.1\|1842771_1844250_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.8e-283	97.6
WP_072414246.1\|1844408_1844864_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	1.5e-78	98.6
WP_001795535.1\|1845166_1845817_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	2.7e-44	88.4
WP_000070655.1\|1845897_1846893_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	6.2e-77	98.8
WP_000669027.1\|1846968_1847595_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	5.3e-90	93.8
WP_000627537.1\|1847635_1847977_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	3.0e-55	95.6
WP_000414214.1\|1848077_1848650_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	1.1e-25	96.6
WP_000864136.1\|1848847_1849405_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	3.7e-79	96.8
WP_000375476.1\|1849775_1849952_-	hypothetical protein	NA	NA	NA	NA
WP_000731412.1\|1851059_1851503_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000731418.1\|1851502_1851946_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000745473.1\|1851945_1852389_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000221410.1\|1852927_1855351_+	polysaccharide lyase 8 family protein	NA	NA	NA	NA
WP_072414244.1\|1855474_1855834_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000759947.1\|1856057_1856498_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000926706.1\|1856542_1858156_+	lipase	NA	NA	NA	NA
WP_000095395.1\|1858170_1858470_+	secretion protein	NA	NA	NA	NA
WP_000072556.1\|1858596_1859832_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	6.4e-47	37.2
WP_000028658.1\|1859824_1861381_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	3.4e-287	99.0
WP_031835054.1\|1861544_1861679_-	hypothetical protein	NA	NA	NA	NA
WP_001038693.1\|1861745_1862465_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.2e-130	99.2
WP_001038760.1\|1862615_1863332_-\|protease	serine protease SplE	A0A2H4PQN5	Staphylococcus_phage	3.2e-131	99.6
WP_103150108.1\|1863433_1863541_+	hypothetical protein	NA	NA	NA	NA
WP_001038723.1\|1863489_1864209_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	4.3e-128	97.9
WP_001038866.1\|1864329_1865049_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	3.5e-130	98.7
WP_001039455.1\|1865106_1865829_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	1.2e-130	99.2
WP_025174851.1\|1865953_1866661_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	2.4e-123	95.7
WP_001092783.1\|1867624_1868194_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	2.6e-51	62.6
WP_025174387.1\|1868665_1868884_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	9.2e-26	80.6
WP_000550254.1\|1869139_1869613_+	hypothetical protein	NA	NA	NA	NA
WP_000543848.1\|1869617_1870409_+	DUF1828 domain-containing protein	NA	NA	NA	NA
WP_000782463.1\|1870778_1871762_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	1.8e-185	99.4
WP_000473596.1\|1871763_1872699_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0
WP_001086053.1\|1873592_1874048_+	hypothetical protein	Q4ZCB9	Staphylococcus_virus	1.7e-61	76.8
WP_000206349.1\|1874060_1874849_+	DUF1828 domain-containing protein	A0A2H4PQI0	Staphylococcus_phage	1.0e-138	95.0

DBSCAN-SWA_9

1999411 : 2005090

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000669789.1\|1999411_1999591_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001791826.1\|1999901_2000162_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702262.1\|2000214_2000565_-	complement inhibitor SCIN-A	A7TWS0	Staphylococcus_phage	7.5e-54	100.0
WP_000727643.1\|2001247_2001697_+	chemotaxis-inhibiting protein CHIPS	A7TWR9	Staphylococcus_phage	1.5e-78	100.0
WP_000595392.1\|2002996_2004013_-	bi-component leukocidin LukGH subunit G	A0A1X9IGW5	Staphylococcus_phage	6.7e-26	30.2
WP_000791411.1\|2004034_2005090_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	2.8e-35	34.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022719

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP022718

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection