CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP034169	Enterococcus avium strain 352 chromosome, complete genome	2 crisprs	RT,cas6,cas8b2,cas7,cas5,cas3,cas4,cas1,cas2,WYL,cas14j,csa3,DEDDh,DinG	2	3	13	2
NZ_CP034168	Enterococcus avium strain 352 plasmid unnamed, complete sequence	1 crisprs	NA	0	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP034169_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP034169_1

137433-138974

Unclear

Consensus_repeat	Method
GTCTAAATCTAAAAATAGTGGAATGTAAAT	PILER-CR
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CRISPRCasFinder
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CRT

23 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6,RT

The CRISPR arrays of NZ_CP034169_1

>merge|NZ_CP034169|1|137433-138974|PILER-CR,CRISPRCasFinder,CRT
GTCTAAATCTAAAAATAGTGGAATGTAAATCAATCAAGGAGGAAATATTATGAATAAAACTTTAGCGTCTAAATCTAAAAATAGTGGAATGTAAATTCTTTTCTTGAACGAGTTAGATGTAGAGTGTGCCGGTCTAAATCTAAAAATAGTGGAATGTAAATTACGTAAGAAATAACAAATTGGCTAAAAGAGATACAGTCTAAATCTAAAAATAGTGGAATGTAAATAACGTTTTAAATCTGCAGAATGGCTAGATGCCGATAGTCTAAATCTAAAAATAGTGGAATGTAAATTTAGAAACAGGACAAATTGAGACAGTAGAAATTACGGTCTAAATCTAAAAATAGTGGAATGTAAATAATTCTAAGGAGGTGACACTTTGAATGATGATTTAAGTCTAAATCTAAAAATAGTGGAATGTAAATAAGGTATTAAGACATCGATTCAAAATGCTAAAACTGTCTAAATCTAAAAATAGTGGAATGTAAATGGATGTGATAAACCTAAAATATCAATCACAATCGGTCTAAATCTAAAAATAGTGGAATGTAAATCATATATTTATCGACAATTTCTTTTAGTTCGTCACGTCTAAATCTAAAAATAGTGGAATGTAAATGATGTTCATGCAGGCAAAGGATCAACAATCGGTACGGTCTAAATCTAAAAATAGTGGAATGTAAATACCCATCTCGTTAATTATTGTTTCAGCCATTAATGAGTCTAAATCTAAAAATAGTGGAATGTAAATAATTACGGCGTTAAAGTCGACGAGATCACGATAAAACGTCTAAATCTAAAAATAGTGGAATGTAAATTCCTGTTAAGTGACGTTGGATACCGCCGATCGATTGGTCTAAATCTAAAAATAGTGGAATGTAAATGCAAATGCAAAGCTGCTTTACGGAGAAATTACAGCTCGTCTAAATCTAAAAATAGTGGAATGTAAATCTCGTTGATTGTCTTTGATCCATAGGTTGTGATATGTCTAAATCTAAAAATAGTGGAATGTAAATTCTTCTGAATACCGTTGCTAGTCATAGCTGTTCCCACGTCTAAATCTAAAAATAGTGGAATGTAAATCACATAATTAACTAACTCCATGTCACCCTTATGGTGTCTAAATCTAAAAATAGTGGAATGTAAATTTCGAAGTCTAAAACTGATGCGATCCGCATAGCATTTGTCTAAATCTAAAAATAGTGGAATGTAAATGTCATCGGGAAAATGCAACGAGATTCTCGAAACGCGTCTAAATCTAAAAATAGTGGAATGTAAATCCATTATACTTCCGTTGGTGATATTACGGATTACATGTCTAAATCTAAAAATAGTGGAATGTAAATTTCTATGTTAGTAGAAATCTGATTACTGTAATTGGTCTAAATCTAAAAATAGTGGAATGTAAATGAGTTAGACGATTTTTGGGGAATCGGAAGTCGTATGGTCTAAATCTAAAAATAGTGGAATGTAAATTCTTTAGCATACAATTTGTTTCCTGCAAAAATCACAGTCTAAATCTAAAAATATTGGAGTACTAAT

>NZ_CP034169|1|1|137433-138908|PILER-CR
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CAATCAAGGAGGAAATATTATGAATAAAACTTTAGC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTTTCTTGAACGAGTTAGATGTAGAGTGTGCCG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TACGTAAGAAATAACAAATTGGCTAAAAGAGATACA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AACGTTTTAAATCTGCAGAATGGCTAGATGCCGATA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTAGAAACAGGACAAATTGAGACAGTAGAAATTACG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AATTCTAAGGAGGTGACACTTTGAATGATGATTTAA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AAGGTATTAAGACATCGATTCAAAATGCTAAAACT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GGATGTGATAAACCTAAAATATCAATCACAATCG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CATATATTTATCGACAATTTCTTTTAGTTCGTCAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GATGTTCATGCAGGCAAAGGATCAACAATCGGTACG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	ACCCATCTCGTTAATTATTGTTTCAGCCATTAATGA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AATTACGGCGTTAAAGTCGACGAGATCACGATAAAAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCCTGTTAAGTGACGTTGGATACCGCCGATCGATTG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GCAAATGCAAAGCTGCTTTACGGAGAAATTACAGCTC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CTCGTTGATTGTCTTTGATCCATAGGTTGTGATAT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTCTGAATACCGTTGCTAGTCATAGCTGTTCCCAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CACATAATTAACTAACTCCATGTCACCCTTATGGT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTCGAAGTCTAAAACTGATGCGATCCGCATAGCATTT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GTCATCGGGAAAATGCAACGAGATTCTCGAAACGC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CCATTATACTTCCGTTGGTGATATTACGGATTACAT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTCTATGTTAGTAGAAATCTGATTACTGTAATTG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GAGTTAGACGATTTTTGGGGAATCGGAAGTCGTATG
GTCTAAATCTAAAAATAGTGGAATGTAAAT

>NZ_CP034169|1|1|137433-138974|CRISPRCasFinder
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CAATCAAGGAGGAAATATTATGAATAAAACTTTAGC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTTTCTTGAACGAGTTAGATGTAGAGTGTGCCG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TACGTAAGAAATAACAAATTGGCTAAAAGAGATACA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AACGTTTTAAATCTGCAGAATGGCTAGATGCCGATA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTAGAAACAGGACAAATTGAGACAGTAGAAATTACG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AATTCTAAGGAGGTGACACTTTGAATGATGATTTAA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AAGGTATTAAGACATCGATTCAAAATGCTAAAACT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GGATGTGATAAACCTAAAATATCAATCACAATCG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CATATATTTATCGACAATTTCTTTTAGTTCGTCAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GATGTTCATGCAGGCAAAGGATCAACAATCGGTACG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	ACCCATCTCGTTAATTATTGTTTCAGCCATTAATGA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AATTACGGCGTTAAAGTCGACGAGATCACGATAAAAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCCTGTTAAGTGACGTTGGATACCGCCGATCGATTG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GCAAATGCAAAGCTGCTTTACGGAGAAATTACAGCTC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CTCGTTGATTGTCTTTGATCCATAGGTTGTGATAT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTCTGAATACCGTTGCTAGTCATAGCTGTTCCCAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CACATAATTAACTAACTCCATGTCACCCTTATGGT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTCGAAGTCTAAAACTGATGCGATCCGCATAGCATTT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GTCATCGGGAAAATGCAACGAGATTCTCGAAACGC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CCATTATACTTCCGTTGGTGATATTACGGATTACAT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTCTATGTTAGTAGAAATCTGATTACTGTAATTG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GAGTTAGACGATTTTTGGGGAATCGGAAGTCGTATG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTTAGCATACAATTTGTTTCCTGCAAAAATCACA
GTCTAAATCTAAAAATATTGGAGTACTAAT

>NZ_CP034169|1|1|137433-138974|CRT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CAATCAAGGAGGAAATATTATGAATAAAACTTTAGC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTTTCTTGAACGAGTTAGATGTAGAGTGTGCCG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TACGTAAGAAATAACAAATTGGCTAAAAGAGATACA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AACGTTTTAAATCTGCAGAATGGCTAGATGCCGATA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTAGAAACAGGACAAATTGAGACAGTAGAAATTACG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AATTCTAAGGAGGTGACACTTTGAATGATGATTTAA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AAGGTATTAAGACATCGATTCAAAATGCTAAAACT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GGATGTGATAAACCTAAAATATCAATCACAATCG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CATATATTTATCGACAATTTCTTTTAGTTCGTCAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GATGTTCATGCAGGCAAAGGATCAACAATCGGTACG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	ACCCATCTCGTTAATTATTGTTTCAGCCATTAATGA
GTCTAAATCTAAAAATAGTGGAATGTAAAT	AATTACGGCGTTAAAGTCGACGAGATCACGATAAAAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCCTGTTAAGTGACGTTGGATACCGCCGATCGATTG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GCAAATGCAAAGCTGCTTTACGGAGAAATTACAGCTC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CTCGTTGATTGTCTTTGATCCATAGGTTGTGATAT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTCTGAATACCGTTGCTAGTCATAGCTGTTCCCAC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CACATAATTAACTAACTCCATGTCACCCTTATGGT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTCGAAGTCTAAAACTGATGCGATCCGCATAGCATTT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GTCATCGGGAAAATGCAACGAGATTCTCGAAACGC
GTCTAAATCTAAAAATAGTGGAATGTAAAT	CCATTATACTTCCGTTGGTGATATTACGGATTACAT
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TTCTATGTTAGTAGAAATCTGATTACTGTAATTG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	GAGTTAGACGATTTTTGGGGAATCGGAAGTCGTATG
GTCTAAATCTAAAAATAGTGGAATGTAAAT	TCTTTAGCATACAATTTGTTTCCTGCAAAAATCACA
GTCTAAATCTAAAAATATTGGAGTACTAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP034169.1\|WP_137438874.1\|146821_147103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034169.1\|WP_137438868.1\|136964_137246_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP034169.1\|WP_137438865.1\|132415_133168_+\|CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|187789
NZ_CP034169.1\|WP_137438866.1\|133176_135459_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|273707
NZ_CP034169.1\|WP_167494422.1\|144510_144894_+\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|225197
NZ_CP034169.1\|WP_137438869.1\|139526_140351_+\|SWIM-zinc-finger-family-protein	unknown	unknown	gnl\|CDD\|309540
NZ_CP034169.1\|WP_137438867.1\|135468_135957_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP034169.1\|WP_137438871.1\|141777_142686_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP034169.1\|WP_137438860.1\|126707_128024_-\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
NZ_CP034169.1\|WP_137438863.1\|129863_131549_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09754_cas8b2_CAS-I-B	gnl\|CDD\|187884
NZ_CP034169.1\|WP_137440439.1\|139174_139513_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034169.1\|WP_137438872.1\|142764_143685_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP034169.1\|WP_049221955.1\|143677_144403_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|378937
NZ_CP034169.1\|WP_137440438.1\|135969_136959_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_CP034169.1\|WP_137438862.1\|129108_129861_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP034169.1\|WP_137438870.1\|141075_141777_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP034169.1\|WP_137438873.1\|145366_146755_+\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP034169.1\|WP_154059601.1\|128527_129082_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034169.1\|WP_137438864.1\|131535_132429_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NZ_CP034169.1\|WP_137438875.1\|147286_148126_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381358

Protein	Function_ID	Function_description	E-value
NZ_CP034169.1\|WP_137438868.1\|136964_137246_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.25195e-27
NZ_CP034169.1\|WP_137438865.1\|132415_133168_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|187789	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	7.21709e-20
NZ_CP034169.1\|WP_137438866.1\|133176_135459_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	2.08577e-64
NZ_CP034169.1\|WP_167494422.1\|144510_144894_+\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|225197	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown].	5.73005e-24
NZ_CP034169.1\|WP_137438860.1\|126707_128024_-\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	9.58776e-71
NZ_CP034169.1\|WP_137438867.1\|135468_135957_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	2.94355e-63
NZ_CP034169.1\|WP_137438871.1\|141777_142686_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.43771e-47
NZ_CP034169.1\|WP_137438869.1\|139526_140351_+\|SWIM-zinc-finger-family-protein	gnl\|CDD\|309540	pfam04434, SWIM, SWIM zinc finger. This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organized into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (pfam00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts.	0.00556114
NZ_CP034169.1\|WP_137438863.1\|129863_131549_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187884	cd09754, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	3.06933e-14
NZ_CP034169.1\|WP_137438872.1\|142764_143685_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	5.56095e-95
NZ_CP034169.1\|WP_049221955.1\|143677_144403_+\|ABC-transporter-permease-subunit	gnl\|CDD\|378937	pfam12730, ABC2_membrane_4, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	7.48057e-11
NZ_CP034169.1\|WP_137440438.1\|135969_136959_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	6.67332e-161
NZ_CP034169.1\|WP_137438862.1\|129108_129861_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.58711e-25
NZ_CP034169.1\|WP_137438870.1\|141075_141777_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.53751e-87
NZ_CP034169.1\|WP_137438873.1\|145366_146755_+\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	5.47186e-177
NZ_CP034169.1\|WP_137438864.1\|131535_132429_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	2.54933e-54
NZ_CP034169.1\|WP_137438875.1\|147286_148126_+\|aldo/keto-reductase	gnl\|CDD\|381358	cd19132, AKR_AKR5D1_E1, AKR5D and AKR5E families of aldo-keto reductase (AKR). 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).	1.27551e-160

>NZ_CP034169.1|WP_137438868.1|136964_137246_+|CRISPR-associated-endonuclease-Cas2
MYVILVYDISLEEKGARVLNRVFKICKKYLSHVQKSVFEGEITPAKLKKLEQELKEYVREDLDSILIFKNSNKKWLKKEYIGIDGTELVSNFF
>NZ_CP034169.1|WP_137440438.1|135969_136959_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MESYYLYSSGTLSRKDNVIRMETADGRKKDLKIEMTRDIYLFGEVTTNTKCLNYLSEMKIPVHFFNYYGYYTGTFYPREKNVSGKLLVQQVYHSAEEEKRIILARKFVDGATANCLRNLQYYRRRGKEVERQITEIEAVRKRIPRTNEVEELMGLEGNIHQIYYSAWETIFNDEIEFKQRVRRPPDNMVNTLISYLNMLTYSACLSEIYVSQLNPTISYLHSNSERRFSLSLDIAEIFKPLIVDRLIFSLINKKIITEKDFETGSNGNYLKQTGQQKVLRQFDERLNKTIRHRELKRNVSYRKLMRLECYKLIKHLMSDKEYEPFKIWW
>NZ_CP034169.1|WP_137438867.1|135468_135957_+|CRISPR-associated-protein-Cas4
MKITGNMINYYFVCERKLWLFAHGLQYEEENENVQLGKLLDTGTYKDKRKQIMLDGTVNIDFLEDWKVLHEVKKSRAIEPAAVWQLRYYLYYLQKKGVSVEKGYIDYPKLRERIEVTLDGEETRELEGIIESIEAIITQEDSPKVEKKKICTKCAYYDYCFI
>NZ_CP034169.1|WP_137438866.1|133176_135459_+|CRISPR-associated-helicase-Cas3'
MEDRFWAKSTEETIVEHTQKLLERYTQLQKNYPEIPVNWDLLRIACQYHDLGKMNKLFQEKIREGVMKKDGEIPHGLLSITLLPFEQLEERYERKEIKALTYAVALHHERNLSEIEEEQYESEAEALMVLIEEFPFDELDLPKPDEIEVPSVIYYKLRHKISSQDDCFRESVMLKGLLNRIDYAASGDYQIEYPANFLNKNMPKVRESWRKKHSDPTINWNEMQKYVQTHQDESLVIIGQTGLGKTEAGLLWIGDNKGFFTLPLRTAINAIYERIRKDITDKTEDKYKEQVGILHSDSLAVLLAEQEENKEIELDQLEGYLTETRSWSLPLTVTTLDQTFDFVYHYAGFEQKLATFAYSKVVIDEIQMYSPDLLAYLIKGLKEIQDFGGKFLVMTATLPPYLLDLFEKRKLIWKSNDKPFLNHELLERHHLQILEEGISAEAVSDLYGSGKLLVICNTVRKAKEIYKELSELSVGVDIHLIHSQFIRKDRQAKEKEIQDFADSEEEGIWIATQVVEASLDIDFDLLITELSELNGLFQRMGRCYRKRSLVNREQPNVYVFDGGDQVTSGISTSEQAVVQKDIFDMSKLALRNVGSGIYSELDKMTIIDQTYTTENMKKTDYYKRIETMLQWLTAIEDDGKSAAEVRKLFRNIQSRNIIPEDVYKNYSEKIDEYLELLPLTNKELESRGYKNPKMYKQQIKSQLEDYMMSIPEWLFRNCLKGDQVRCEQIGRYDQVFFVKGIYESDVGFQVLKGEKEDNVW
>NZ_CP034169.1|WP_137438865.1|132415_133168_+|CRISPR-associated-protein-Cas5
MKGIKLTVHQDMVNYRRPTSFQLRETYPLPPLSTVIGMVHNLCGYQHYEPMDVSIQGNYFSKTNDLFTRYEFKNGMKFEKARHQLKVNEFGVSRGIGYTELLVDVHLILHIVPDNQEKVEEIYQFLKYPAEFPSLGRREDLANFEKVSIVEINEQKLKKDKKIRDQWHAYIPIEKIEDESISIEAEGTGLSGTRFTLPKVYELYNFGTKNKPKFKRNWVERKEVLYSSVFVFPKRVNVLMDEEEDIVFLM
>NZ_CP034169.1|WP_137438864.1|131535_132429_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MTMSKGLTMTMIFLAESANYGESLGNVATLKKITRGKGEQYTYISRQAIRYNIVEQLDEPLASLSAEGSGTKQVIQFDQHATIDKYPEVDLFGYMKTAKGDNALTRSAKVRLSNAVSLETYKGDTDFLTNMGLAKRLRENGDEKAMNSIAQSEIHRSFYRYTVTVDLDEIGIDRNVDIKLSNEEKSRRVQKLLDTIQYLYRDIRGRRENLQPLFIVGGVYERKNPLFENVVDVHQNKVDVEKIEGVLTDALWQDTFVGVVKDAFENTAEIQEVLQGQKIPQVFESLKQKVADYYEGD
>NZ_CP034169.1|WP_137438863.1|129863_131549_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MDSIEKDDTLEFRLNSWMENAAICGLVNILEEDEDKIEIKPQSIVVKKEVFKNFEEDYFTYFAKQYEKLSSLTKVLSYEDEMNRHQREDFTHFDQKAYERLQKYLADLKRYGESNSYLAVYPLVDSSVDIVSLIKKAKIDKLKKGEFEHNNIEIIDRIKSIYELLTEIFAYYHQEDVQRYLAAKIQIYSVINNGYNDVSFLNRQESKGDFYEKYHDYFVESMLSYLEDNHEKDKLSCTNCGHPIKKGDISYSFINQAGYDANRKQSNAWSFTNDLFMCPVCRLLYTCIPAGFTYVYNQGLFVNDNHSVRALLNANTGIRLDVLSLNKTEVKAIDTYAALIRTLQDSMNRQHHRELQDIQVVRYENERYYFNLLPKHILKTIDQSKDKLPELFNAGFILNGDYQSLYREIITRLMNNTNLFSLIYQVLRTKGTGGQVYANTYHIMKMIEINQNFLKELIQMEKLEKDELEKIRRDGYFLKKEYANKNKADSIGLRLLNALKANNKDAFMDILLNSYMYLNKLVPKYFTDIFLDDERFKTIGYSFVAGIIGEAHNTEGGNDNE
>NZ_CP034169.1|WP_137438862.1|129108_129861_+|CRISPR-associated-endoribonuclease-Cas6
MRFKINLKVHSSNEEIEIPIKYQSIFLSLLKRGLENAAPEVYKELYEKNKEKLFSQAIIFKGAMFEKEKIILKTPSITYLFSTPKADLAMAVYNAFIYLKEMKAVPFVGESTIKVKSVSSIYQETITEKQVIFQAISPILARDHNRETRKDWFLDFNDEKYEVVLKQNLINRLVPEMGRGVQYDIENLKMKPLNMKKTVTKAYEKFYQGAIGTIELTGEPYLLNVIRDVGLGSKTGLYFGYLNQVKQGGE
>NZ_CP034169.1|WP_154059601.1|128527_129082_+|hypothetical-protein
MILINQNLWLWIFKVLVFLGAVGYIHLFIKRIRKRNKYFKGNIFVSQSGELWLRFKGEEEVLKTITSKMRVIDEEPNNVNERLETDQANIHIEKTSGFVQVTTGNGISKQLIEGNSFSNKLEQYRSLMIGSGILEEDIDALILHAKDEDVKNSFLAKYGMELAKIMVNVAGTTISLISLLKKSI
>NZ_CP034169.1|WP_137438860.1|126707_128024_-|ISL3-family-transposase
MSSIKNIKYKDNCLDKTIKQILNIHDSNITFPKDAVSKEKVHDRMATVFTGRLSYPSPRCECCGYDSVIHHGYKDSWIQLLPYQEVSTYLHLYKQRFYCKQCHHTFSAKTYYVAENCYLSQALKFAIAVDLKKKISMKDIAQRYLVSAKTVERVLDSFFEEPRLKPNYLPKHLLIDEFKGTKDCQGAMCFILSDADTGKIFDILEDRRSFKLIAYFMRFTYHARKNVSHVVMDMNAGYDSVTKVVFPNARISIDRFHVIQQLNRAFNKQRIKTMNHLKKSDPQAMKKYRKLKKYWRTILKKNRKINYSSLKQYPLFQRKYLTESEVLDYLLSIDKHLRTSYDVYQNLLDAFDAKDYTDFYERIDHLPPMLDPAFKKAILYLNKHKQAIINALKYPYSNGKLEGKNNLIKVIKRVAFGFRTFRHLRMRILIQQNLCDII
>NZ_CP034169.1|WP_137440439.1|139174_139513_+|hypothetical-protein
MKGQFEKRMIIPLDRDLIWVWPDIQAYLYGRNNLDFSRYALFTFEIPAISYKNDILWSDFFSWHEVLNRLWEGKADESERYEEIFQLKKHEKAGRIQGITTRLHKDWIKRIT
>NZ_CP034169.1|WP_137438869.1|139526_140351_+|SWIM-zinc-finger-family-protein
MGDWERLFKPHILERGYEYFLEERVVDFWLKDDLIKASVAGTDDYEVVIEGIGYDFPRLYCDCPFADTDNNCKHMAAVLYEYEDGKIDGRWEEKTKLSKNVEEMVLNAEDSVVREFLIELLKKDQSLAHRFARLISPQITGRDIQQLNHKIDKIIKQHAGYENSLEYQEIENFVADLIEFINEEITPVIDKEAYLVAFQLINHIVLEVREVDIDDLEGELFELSAECRYTWESILNKATKQEREEMHSWFKTQLNQAKYYFDYGEIEQIYEDRF
>NZ_CP034169.1|WP_137438870.1|141075_141777_+|response-regulator-transcription-factor
MQEKTKVLIIDDDQELCSIIDRYLKNAGYETQLVHTGAGGLQLALSGDYHLIVLDIMLPQIDGMSILAEIRRQSVVPILMLTAKNEEADKIRGLQLGADDYLTKPFSMAELMARVESLVRRYMKFSRAAVDETALVLKHLTLDRQTRIVLLEGKSLELTGKEFELLYFLASHKGQIFTKRQIYQQVWGTEYAFDDNNIMSFISKLRKKIEPDVAQPFFIQTVRGVGYRFNQEG
>NZ_CP034169.1|WP_137438871.1|141777_142686_+|HAMP-domain-containing-histidine-kinase
MMLVLSIICLLLAVVCLLLIVRLRQNRRQIAQAMVVLEDIGEGNLDRKIVVDENSDIAALCFRLNEIVSEIKQQLSRLRVSENEYRKLITSLSHDVRTPLASLIGYLEAITDGLVTEAEQQEYLRAAQAKAFELETYIDTLFEWVKLESGERHYHFEATDISELLREIVSEWIPRMEMRFSYDIQIPEKELRCTIDAAAFRRIIDNLLENCLKHSRGNRVTIRLFEQDQQVRLEISDNGRGISEQHLPRIFDRLYKGDEARGSKGNGLGLAIVQELVTAHHGEINVCSKLGEGTKFYVTLPK
>NZ_CP034169.1|WP_137438872.1|142764_143685_+|ABC-transporter-ATP-binding-protein
MEKFIVKTAALSKRYSDQIVVKDVSMSIPKGKIYGLLGRNGAGKTTIMKILLGLASASSGEVRLFNQSPKKHPEVYSRIGNMIETPSFYPYLSGPENLSVFSKLKGQIQKSSVEKALKLVDLSRAGHKRFANYSLGMKQRLGIANALMNDPELLILDEPTNGLDPIGIAEIRKLLKELAEVHGKTILISSHQLSEIEQIADIIGILHDGALLEECDMSQIAQHNQRFIHITVSDVHQATRLLEEEMQLTNYSVAENNTIKIFEFTYEPQEINHLFGKNGIEVSSLFFGSGNLEEHFREITGGVGIA
>NZ_CP034169.1|WP_049221955.1|143677_144403_+|ABC-transporter-permease-subunit
MLNVISAEWLKLRSNRIFTVCSLLTLLTSAFMVFRDLVIVDNPPESYQMWLPSIYIVVGMVLSIMSGFIITFLMQREYEDRTINNVLTAPTSRGRYLFGKLVIWFIWYLGTLIGVVTIYTIGGWLIYPDTFGLTGTKILVSTLLKYCLLGFVAAIPLLTISVVQRKLFYPTIMVALVFTGIQTFALNIPFKFARIIPWSAVVVQSLMELTLKDDLLTLGSIFLTGIVGLLAAYWLFKKQDL
>NZ_CP034169.1|WP_167494422.1|144510_144894_+|MmcQ/YjbR-family-DNA-binding-protein
MENKVLQQRIETFKVFGETLKGAKVYFREDWGVLYFDLQGKMFGMMSNQASEDAIITLKNLPEKNEELREIYVGIVIPGYYTNKNHWNSIKLTSEELTDDVIKQLIEVSYQLVYQKLTKKQKAEIEG
>NZ_CP034169.1|WP_137438873.1|145366_146755_+|group-II-intron-reverse-transcriptase/maturase
MRRPQKTRKLGYHQRVSVEHEGYDEVRSTSCGEQRKQDGVENLFGRILERNNLNQAYLQVVRNKGAAGADGMTVDQLLPYLKEHREELLSNLRQGNYKPQPVLRVEIPKPNGGVRKLGIPTVIDRMLQQAINQVLQPLFEPEFSDNSYGFRPNRSAHDAVKKAKSYYEQGYRYVVDIDMKAYFDTVNHDKLMYFVERKVKDKQVLKLIRQYLMSGVMENGLITTTEEGTPQGGNLSPLLSNIYLNEFDQVLENLGHKFVRYADDCNIYVRSKRAGQRVMKKSIQFLEEQLKLTVNREKSAVGSPLKRKFLGFCILPTKKGSKIRPHAKAKQRVKSKLKQLTKRNRGRSIQLILKEIKQLMTGWINYYGIGEMKEFMRELNGWLKRRIRQYIWKQWKNPRTKRKNLIRLGIDKAKAYEWSNTRKGIWSISKSHILHRSLTDKELARQGYEDISLKYQFVHSTY
>NZ_CP034169.1|WP_137438874.1|146821_147103_-|hypothetical-protein
MDSIICIVLGMLFANGVPHFVKGITAEKWDVPWKKPASASTNVLWGIANWLVVVILYALFKPDVNSFDAACFLIGMGITGYYLALHWSEKTIE
>NZ_CP034169.1|WP_137438875.1|147286_148126_+|aldo/keto-reductase
MKAPLITMNDGHQIPAVGLGTYQIRGGEGLDQILTAIQDGYRLLDTSTNYDSEGIVGEAIRRSGIPRSEFFVTTKLPGKYHHYEDALMMIQESLFRMGLDYFDLYLIHWPLPKRGLYVEAWKAMVTAQKLGLIRSIGVSNFEPEHLDKIIDETGVTPAINQIEIHPYWVQERMVKANQERGILTEAWSPLGRGSDALKEAVITELAEKYGKTSAQVILRWHAQRGIIPIPKSRNIQHQRENLAIFDFELTQTEIERINLLEKADGRIEGQDPNEYEEFD

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Crispr_ID: NZ_CP034169_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP034169_2

140636-140790

Unclear

Consensus_repeat	Method
AAATCTAAAATAGTGGAATGTAAATA	CRISPRCasFinder

2 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b2,cas6,RT

The CRISPR arrays of NZ_CP034169_2

>merge|NZ_CP034169|2|140636-140790|CRISPRCasFinder
AAATCTAAAATAGTGGAATGTAAATACGGAAGGCAGTACACAGCAACGCGTATTGGCACTTGTTCAAATCTAAAATAGTGGAATGTAAATAAAGGTAAAAATATCGGTAACAGCCAAGTCCTCCCGTTCAAATCTAAAATAATGGAGTATAAATA

>NZ_CP034169|2|2|140636-140790|CRISPRCasFinder
AAATCTAAAATAGTGGAATGTAAATA	CGGAAGGCAGTACACAGCAACGCGTATTGGCACTTGTTC
AAATCTAAAATAGTGGAATGTAAATA	AAGGTAAAAATATCGGTAACAGCCAAGTCCTCCCGTTC
AAATCTAAAATAATGGAGTATAAATA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP034169.1\|WP_137438868.1\|136964_137246_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP034169.1\|WP_137438865.1\|132415_133168_+\|CRISPR-associated-protein-Cas5	cas5	cd09658_cas5_CAS-I-B	gnl\|CDD\|187789
NZ_CP034169.1\|WP_137438866.1\|133176_135459_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|273707
NZ_CP034169.1\|WP_167494422.1\|144510_144894_+\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|225197
NZ_CP034169.1\|WP_016179407.1\|148289_148601_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034169.1\|WP_137438874.1\|146821_147103_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034169.1\|WP_137438867.1\|135468_135957_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP034169.1\|WP_137438871.1\|141777_142686_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP034169.1\|WP_137438869.1\|139526_140351_+\|SWIM-zinc-finger-family-protein	unknown	unknown	gnl\|CDD\|309540
NZ_CP034169.1\|WP_137438863.1\|129863_131549_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	cas8b2	cd09754_cas8b2_CAS-I-B	gnl\|CDD\|187884
NZ_CP034169.1\|WP_137440439.1\|139174_139513_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034169.1\|WP_137438872.1\|142764_143685_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP034169.1\|WP_137438876.1\|148662_149307_-\|ABC-2-transporter-permease	unknown	unknown	gnl\|CDD\|379133
NZ_CP034169.1\|WP_049221955.1\|143677_144403_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|378937
NZ_CP034169.1\|WP_137440438.1\|135969_136959_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
NZ_CP034169.1\|WP_137438862.1\|129108_129861_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP034169.1\|WP_137438870.1\|141075_141777_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP034169.1\|WP_137438873.1\|145366_146755_+\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP034169.1\|WP_137438864.1\|131535_132429_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|274215
NZ_CP034169.1\|WP_137438875.1\|147286_148126_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381358

Protein	Function_ID	Function_description	E-value
NZ_CP034169.1\|WP_137438868.1\|136964_137246_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.25195e-27
NZ_CP034169.1\|WP_137438865.1\|132415_133168_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|187789	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	7.21709e-20
NZ_CP034169.1\|WP_137438866.1\|133176_135459_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	2.08577e-64
NZ_CP034169.1\|WP_167494422.1\|144510_144894_+\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|225197	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown].	5.73005e-24
NZ_CP034169.1\|WP_137438867.1\|135468_135957_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	2.94355e-63
NZ_CP034169.1\|WP_137438871.1\|141777_142686_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.43771e-47
NZ_CP034169.1\|WP_137438869.1\|139526_140351_+\|SWIM-zinc-finger-family-protein	gnl\|CDD\|309540	pfam04434, SWIM, SWIM zinc finger. This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organized into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (pfam00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts.	0.00556114
NZ_CP034169.1\|WP_137438863.1\|129863_131549_+\|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl\|CDD\|187884	cd09754, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as CXXC_CXXC family.	3.06933e-14
NZ_CP034169.1\|WP_137438872.1\|142764_143685_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	5.56095e-95
NZ_CP034169.1\|WP_137438876.1\|148662_149307_-\|ABC-2-transporter-permease	gnl\|CDD\|379133	pfam13346, ABC2_membrane_5, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	0.000669416
NZ_CP034169.1\|WP_049221955.1\|143677_144403_+\|ABC-transporter-permease-subunit	gnl\|CDD\|378937	pfam12730, ABC2_membrane_4, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	7.48057e-11
NZ_CP034169.1\|WP_137440438.1\|135969_136959_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	6.67332e-161
NZ_CP034169.1\|WP_137438862.1\|129108_129861_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.58711e-25
NZ_CP034169.1\|WP_137438870.1\|141075_141777_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.53751e-87
NZ_CP034169.1\|WP_137438873.1\|145366_146755_+\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	5.47186e-177
NZ_CP034169.1\|WP_137438864.1\|131535_132429_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|274215	TIGR02585, conserved_protein, CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This clade is a member of the DevR family (TIGR01875) and includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to be regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.	2.54933e-54
NZ_CP034169.1\|WP_137438875.1\|147286_148126_+\|aldo/keto-reductase	gnl\|CDD\|381358	cd19132, AKR_AKR5D1_E1, AKR5D and AKR5E families of aldo-keto reductase (AKR). 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).	1.27551e-160

>NZ_CP034169.1|WP_137438869.1|139526_140351_+|SWIM-zinc-finger-family-protein
MGDWERLFKPHILERGYEYFLEERVVDFWLKDDLIKASVAGTDDYEVVIEGIGYDFPRLYCDCPFADTDNNCKHMAAVLYEYEDGKIDGRWEEKTKLSKNVEEMVLNAEDSVVREFLIELLKKDQSLAHRFARLISPQITGRDIQQLNHKIDKIIKQHAGYENSLEYQEIENFVADLIEFINEEITPVIDKEAYLVAFQLINHIVLEVREVDIDDLEGELFELSAECRYTWESILNKATKQEREEMHSWFKTQLNQAKYYFDYGEIEQIYEDRF
>NZ_CP034169.1|WP_137440439.1|139174_139513_+|hypothetical-protein
MKGQFEKRMIIPLDRDLIWVWPDIQAYLYGRNNLDFSRYALFTFEIPAISYKNDILWSDFFSWHEVLNRLWEGKADESERYEEIFQLKKHEKAGRIQGITTRLHKDWIKRIT
>NZ_CP034169.1|WP_137438868.1|136964_137246_+|CRISPR-associated-endonuclease-Cas2
MYVILVYDISLEEKGARVLNRVFKICKKYLSHVQKSVFEGEITPAKLKKLEQELKEYVREDLDSILIFKNSNKKWLKKEYIGIDGTELVSNFF
>NZ_CP034169.1|WP_137440438.1|135969_136959_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MESYYLYSSGTLSRKDNVIRMETADGRKKDLKIEMTRDIYLFGEVTTNTKCLNYLSEMKIPVHFFNYYGYYTGTFYPREKNVSGKLLVQQVYHSAEEEKRIILARKFVDGATANCLRNLQYYRRRGKEVERQITEIEAVRKRIPRTNEVEELMGLEGNIHQIYYSAWETIFNDEIEFKQRVRRPPDNMVNTLISYLNMLTYSACLSEIYVSQLNPTISYLHSNSERRFSLSLDIAEIFKPLIVDRLIFSLINKKIITEKDFETGSNGNYLKQTGQQKVLRQFDERLNKTIRHRELKRNVSYRKLMRLECYKLIKHLMSDKEYEPFKIWW
>NZ_CP034169.1|WP_137438867.1|135468_135957_+|CRISPR-associated-protein-Cas4
MKITGNMINYYFVCERKLWLFAHGLQYEEENENVQLGKLLDTGTYKDKRKQIMLDGTVNIDFLEDWKVLHEVKKSRAIEPAAVWQLRYYLYYLQKKGVSVEKGYIDYPKLRERIEVTLDGEETRELEGIIESIEAIITQEDSPKVEKKKICTKCAYYDYCFI
>NZ_CP034169.1|WP_137438866.1|133176_135459_+|CRISPR-associated-helicase-Cas3'
MEDRFWAKSTEETIVEHTQKLLERYTQLQKNYPEIPVNWDLLRIACQYHDLGKMNKLFQEKIREGVMKKDGEIPHGLLSITLLPFEQLEERYERKEIKALTYAVALHHERNLSEIEEEQYESEAEALMVLIEEFPFDELDLPKPDEIEVPSVIYYKLRHKISSQDDCFRESVMLKGLLNRIDYAASGDYQIEYPANFLNKNMPKVRESWRKKHSDPTINWNEMQKYVQTHQDESLVIIGQTGLGKTEAGLLWIGDNKGFFTLPLRTAINAIYERIRKDITDKTEDKYKEQVGILHSDSLAVLLAEQEENKEIELDQLEGYLTETRSWSLPLTVTTLDQTFDFVYHYAGFEQKLATFAYSKVVIDEIQMYSPDLLAYLIKGLKEIQDFGGKFLVMTATLPPYLLDLFEKRKLIWKSNDKPFLNHELLERHHLQILEEGISAEAVSDLYGSGKLLVICNTVRKAKEIYKELSELSVGVDIHLIHSQFIRKDRQAKEKEIQDFADSEEEGIWIATQVVEASLDIDFDLLITELSELNGLFQRMGRCYRKRSLVNREQPNVYVFDGGDQVTSGISTSEQAVVQKDIFDMSKLALRNVGSGIYSELDKMTIIDQTYTTENMKKTDYYKRIETMLQWLTAIEDDGKSAAEVRKLFRNIQSRNIIPEDVYKNYSEKIDEYLELLPLTNKELESRGYKNPKMYKQQIKSQLEDYMMSIPEWLFRNCLKGDQVRCEQIGRYDQVFFVKGIYESDVGFQVLKGEKEDNVW
>NZ_CP034169.1|WP_137438865.1|132415_133168_+|CRISPR-associated-protein-Cas5
MKGIKLTVHQDMVNYRRPTSFQLRETYPLPPLSTVIGMVHNLCGYQHYEPMDVSIQGNYFSKTNDLFTRYEFKNGMKFEKARHQLKVNEFGVSRGIGYTELLVDVHLILHIVPDNQEKVEEIYQFLKYPAEFPSLGRREDLANFEKVSIVEINEQKLKKDKKIRDQWHAYIPIEKIEDESISIEAEGTGLSGTRFTLPKVYELYNFGTKNKPKFKRNWVERKEVLYSSVFVFPKRVNVLMDEEEDIVFLM
>NZ_CP034169.1|WP_137438864.1|131535_132429_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MTMSKGLTMTMIFLAESANYGESLGNVATLKKITRGKGEQYTYISRQAIRYNIVEQLDEPLASLSAEGSGTKQVIQFDQHATIDKYPEVDLFGYMKTAKGDNALTRSAKVRLSNAVSLETYKGDTDFLTNMGLAKRLRENGDEKAMNSIAQSEIHRSFYRYTVTVDLDEIGIDRNVDIKLSNEEKSRRVQKLLDTIQYLYRDIRGRRENLQPLFIVGGVYERKNPLFENVVDVHQNKVDVEKIEGVLTDALWQDTFVGVVKDAFENTAEIQEVLQGQKIPQVFESLKQKVADYYEGD
>NZ_CP034169.1|WP_137438863.1|129863_131549_+|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MDSIEKDDTLEFRLNSWMENAAICGLVNILEEDEDKIEIKPQSIVVKKEVFKNFEEDYFTYFAKQYEKLSSLTKVLSYEDEMNRHQREDFTHFDQKAYERLQKYLADLKRYGESNSYLAVYPLVDSSVDIVSLIKKAKIDKLKKGEFEHNNIEIIDRIKSIYELLTEIFAYYHQEDVQRYLAAKIQIYSVINNGYNDVSFLNRQESKGDFYEKYHDYFVESMLSYLEDNHEKDKLSCTNCGHPIKKGDISYSFINQAGYDANRKQSNAWSFTNDLFMCPVCRLLYTCIPAGFTYVYNQGLFVNDNHSVRALLNANTGIRLDVLSLNKTEVKAIDTYAALIRTLQDSMNRQHHRELQDIQVVRYENERYYFNLLPKHILKTIDQSKDKLPELFNAGFILNGDYQSLYREIITRLMNNTNLFSLIYQVLRTKGTGGQVYANTYHIMKMIEINQNFLKELIQMEKLEKDELEKIRRDGYFLKKEYANKNKADSIGLRLLNALKANNKDAFMDILLNSYMYLNKLVPKYFTDIFLDDERFKTIGYSFVAGIIGEAHNTEGGNDNE
>NZ_CP034169.1|WP_137438862.1|129108_129861_+|CRISPR-associated-endoribonuclease-Cas6
MRFKINLKVHSSNEEIEIPIKYQSIFLSLLKRGLENAAPEVYKELYEKNKEKLFSQAIIFKGAMFEKEKIILKTPSITYLFSTPKADLAMAVYNAFIYLKEMKAVPFVGESTIKVKSVSSIYQETITEKQVIFQAISPILARDHNRETRKDWFLDFNDEKYEVVLKQNLINRLVPEMGRGVQYDIENLKMKPLNMKKTVTKAYEKFYQGAIGTIELTGEPYLLNVIRDVGLGSKTGLYFGYLNQVKQGGE
>NZ_CP034169.1|WP_137438870.1|141075_141777_+|response-regulator-transcription-factor
MQEKTKVLIIDDDQELCSIIDRYLKNAGYETQLVHTGAGGLQLALSGDYHLIVLDIMLPQIDGMSILAEIRRQSVVPILMLTAKNEEADKIRGLQLGADDYLTKPFSMAELMARVESLVRRYMKFSRAAVDETALVLKHLTLDRQTRIVLLEGKSLELTGKEFELLYFLASHKGQIFTKRQIYQQVWGTEYAFDDNNIMSFISKLRKKIEPDVAQPFFIQTVRGVGYRFNQEG
>NZ_CP034169.1|WP_137438871.1|141777_142686_+|HAMP-domain-containing-histidine-kinase
MMLVLSIICLLLAVVCLLLIVRLRQNRRQIAQAMVVLEDIGEGNLDRKIVVDENSDIAALCFRLNEIVSEIKQQLSRLRVSENEYRKLITSLSHDVRTPLASLIGYLEAITDGLVTEAEQQEYLRAAQAKAFELETYIDTLFEWVKLESGERHYHFEATDISELLREIVSEWIPRMEMRFSYDIQIPEKELRCTIDAAAFRRIIDNLLENCLKHSRGNRVTIRLFEQDQQVRLEISDNGRGISEQHLPRIFDRLYKGDEARGSKGNGLGLAIVQELVTAHHGEINVCSKLGEGTKFYVTLPK
>NZ_CP034169.1|WP_137438872.1|142764_143685_+|ABC-transporter-ATP-binding-protein
MEKFIVKTAALSKRYSDQIVVKDVSMSIPKGKIYGLLGRNGAGKTTIMKILLGLASASSGEVRLFNQSPKKHPEVYSRIGNMIETPSFYPYLSGPENLSVFSKLKGQIQKSSVEKALKLVDLSRAGHKRFANYSLGMKQRLGIANALMNDPELLILDEPTNGLDPIGIAEIRKLLKELAEVHGKTILISSHQLSEIEQIADIIGILHDGALLEECDMSQIAQHNQRFIHITVSDVHQATRLLEEEMQLTNYSVAENNTIKIFEFTYEPQEINHLFGKNGIEVSSLFFGSGNLEEHFREITGGVGIA
>NZ_CP034169.1|WP_049221955.1|143677_144403_+|ABC-transporter-permease-subunit
MLNVISAEWLKLRSNRIFTVCSLLTLLTSAFMVFRDLVIVDNPPESYQMWLPSIYIVVGMVLSIMSGFIITFLMQREYEDRTINNVLTAPTSRGRYLFGKLVIWFIWYLGTLIGVVTIYTIGGWLIYPDTFGLTGTKILVSTLLKYCLLGFVAAIPLLTISVVQRKLFYPTIMVALVFTGIQTFALNIPFKFARIIPWSAVVVQSLMELTLKDDLLTLGSIFLTGIVGLLAAYWLFKKQDL
>NZ_CP034169.1|WP_167494422.1|144510_144894_+|MmcQ/YjbR-family-DNA-binding-protein
MENKVLQQRIETFKVFGETLKGAKVYFREDWGVLYFDLQGKMFGMMSNQASEDAIITLKNLPEKNEELREIYVGIVIPGYYTNKNHWNSIKLTSEELTDDVIKQLIEVSYQLVYQKLTKKQKAEIEG
>NZ_CP034169.1|WP_137438873.1|145366_146755_+|group-II-intron-reverse-transcriptase/maturase
MRRPQKTRKLGYHQRVSVEHEGYDEVRSTSCGEQRKQDGVENLFGRILERNNLNQAYLQVVRNKGAAGADGMTVDQLLPYLKEHREELLSNLRQGNYKPQPVLRVEIPKPNGGVRKLGIPTVIDRMLQQAINQVLQPLFEPEFSDNSYGFRPNRSAHDAVKKAKSYYEQGYRYVVDIDMKAYFDTVNHDKLMYFVERKVKDKQVLKLIRQYLMSGVMENGLITTTEEGTPQGGNLSPLLSNIYLNEFDQVLENLGHKFVRYADDCNIYVRSKRAGQRVMKKSIQFLEEQLKLTVNREKSAVGSPLKRKFLGFCILPTKKGSKIRPHAKAKQRVKSKLKQLTKRNRGRSIQLILKEIKQLMTGWINYYGIGEMKEFMRELNGWLKRRIRQYIWKQWKNPRTKRKNLIRLGIDKAKAYEWSNTRKGIWSISKSHILHRSLTDKELARQGYEDISLKYQFVHSTY
>NZ_CP034169.1|WP_137438874.1|146821_147103_-|hypothetical-protein
MDSIICIVLGMLFANGVPHFVKGITAEKWDVPWKKPASASTNVLWGIANWLVVVILYALFKPDVNSFDAACFLIGMGITGYYLALHWSEKTIE
>NZ_CP034169.1|WP_137438875.1|147286_148126_+|aldo/keto-reductase
MKAPLITMNDGHQIPAVGLGTYQIRGGEGLDQILTAIQDGYRLLDTSTNYDSEGIVGEAIRRSGIPRSEFFVTTKLPGKYHHYEDALMMIQESLFRMGLDYFDLYLIHWPLPKRGLYVEAWKAMVTAQKLGLIRSIGVSNFEPEHLDKIIDETGVTPAINQIEIHPYWVQERMVKANQERGILTEAWSPLGRGSDALKEAVITELAEKYGKTSAQVILRWHAQRGIIPIPKSRNIQHQRENLAIFDFELTQTEIERINLLEKADGRIEGQDPNEYEEFD
>NZ_CP034169.1|WP_016179407.1|148289_148601_+|hypothetical-protein
MKKVVALMGVLAAILLFFWFNQKGEVKEQTTADFSQPEQVEPSEDFFTNRDLNELEMVTYSRHQEMMDDLTGEGKLVRKSTHKEFVGAKANGEGLSWTAYFEK
>NZ_CP034169.1|WP_137438876.1|148662_149307_-|ABC-2-transporter-permease
MISNLLYKEIRLAAHPNLFVFTLMGPLVLIPGYPYTMVFLFSLIGNFVNLMYTRETNDIYYSTLLPLKKAEVVLGKWLVLLVSQLLTILISIPFAFLRLQLVSQPNPVGIEANTAFYGFGLMIFACFNLIFLTTYFKTGYKVGASFLKGLFPATLLAIILEVIVHFPAFKWLDSVTFNGQMQQLPILAAGILIYIVAMWAAYKISVQRFTQVNL

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP034169_1	1.5\|137726\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137726-137761	36	NZ_CP034169.1	1416560-1416595	0	1.0
NZ_CP034169_1	1.16\|138449\|37\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	138449-138485	37	NZ_CP034169.1	3326710-3326746	0	1.0

1. spacer 1.5|137726|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to position: 1416560-1416595, mismatch: 0, identity: 1.0

ttagaaacaggacaaattgagacagtagaaattacg	CRISPR spacer
ttagaaacaggacaaattgagacagtagaaattacg	Protospacer
************************************

2. spacer 1.16|138449|37|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to position: 3326710-3326746, mismatch: 0, identity: 1.0

tcttctgaataccgttgctagtcatagctgttcccac	CRISPR spacer
tcttctgaataccgttgctagtcatagctgttcccac	Protospacer
*************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP034169_1	1.19\|138648\|35\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	138648-138682	35	NZ_CP019949	Methylocystis bryophila strain S285 plasmid p1, complete sequence	72441-72475	7	0.8
NZ_CP034169_1	1.1\|137463\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137463-137498	36	NZ_CP029399	Streptococcus suis strain HN105 plasmid unnamed1, complete sequence	17466-17501	8	0.778
NZ_CP034169_1	1.1\|137463\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137463-137498	36	NZ_CP013709	Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence	194748-194783	9	0.75
NZ_CP034169_1	1.1\|137463\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137463-137498	36	NZ_CP013682	Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence	196628-196663	9	0.75
NZ_CP034169_1	1.1\|137463\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137463-137498	36	NZ_CP013295	Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence	10363-10398	9	0.75
NZ_CP034169_1	1.1\|137463\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137463-137498	36	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	25194-25229	9	0.75
NZ_CP034169_1	1.4\|137660\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137660-137695	36	NZ_CP042928	Bacillus cereus strain G1-1 plasmid unnamed, complete sequence	304407-304442	10	0.722
NZ_CP034169_1	1.4\|137660\|36\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	137660-137695	36	NZ_CP040341	Bacillus cereus strain DLOU-Tangshan plasmid unnamed1, complete sequence	313264-313299	10	0.722

1. spacer 1.19|138648|35|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019949 (Methylocystis bryophila strain S285 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.8

gtcatcg--ggaaaatgcaacgagattctcgaaacgc	CRISPR spacer
--cttcgacgagaaatccaacgagattctcgaagcgc	Protospacer
  * ***  *..**** ****************.***

2. spacer 1.1|137463|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029399 (Streptococcus suis strain HN105 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.778

caatcaaggaggaaatattatgaataaaactttagc	CRISPR spacer
aaattaaggaggaaataatatgaataaatttgaaac	Protospacer
 ***.************ ********** .*  *.*

3. spacer 1.1|137463|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013709 (Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence) position: , mismatch: 9, identity: 0.75

caatcaaggaggaaatattatgaataaaactttagc	CRISPR spacer
ttaaataggaggaactaatatgaataaaactttaaa	Protospacer
. *   ******** ** ****************.

4. spacer 1.1|137463|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013682 (Clostridium botulinum strain 1169 plasmid pRSJ8_1, complete sequence) position: , mismatch: 9, identity: 0.75

caatcaaggaggaaatattatgaataaaactttagc	CRISPR spacer
ttaaataggaggaactaatatgaataaaactttaaa	Protospacer
. *   ******** ** ****************.

5. spacer 1.1|137463|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013295 (Clostridium botulinum strain CDC_54064 plasmid pNPD1_1, complete sequence) position: , mismatch: 9, identity: 0.75

caatcaaggaggaaatattatgaataaaactttagc	CRISPR spacer
ttaaataggaggaactaatatgaataaaactttaaa	Protospacer
. *   ******** ** ****************.

6. spacer 1.1|137463|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 9, identity: 0.75

caatcaaggaggaaatattatgaataaaactttagc	CRISPR spacer
ttaaataggaggaactaatatgaataaaactttaaa	Protospacer
. *   ******** ** ****************.

7. spacer 1.4|137660|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP042928 (Bacillus cereus strain G1-1 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.722

aacgttttaaatctgcagaatggctagatgccgata	CRISPR spacer
gctgttttaaatcttcagaatgactagatagccact	Protospacer
. .*********** *******.******. * *.

8. spacer 1.4|137660|36|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP040341 (Bacillus cereus strain DLOU-Tangshan plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.722

aacgttttaaatctgcagaatggctagatgccgata	CRISPR spacer
gctgttttaaatcttcagaatgactagatagccact	Protospacer
. .*********** *******.******. * *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

161937 : 226390

Enterococcus_phage(34.09%)

tRNA,portal,capsid,terminase,transposase,integrase,protease

attL 151283:151299|attR 202066:202082

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
151283:151299	attL	NA	NA	NA	NA
WP_049220166.1\|161937_163395_+\|tRNA	glutamate--tRNA ligase	NA	NA	NA	NA
WP_016179422.1\|163843_164377_+	serine O-acetyltransferase	NA	NA	NA	NA
WP_137438879.1\|164369_165779_+\|tRNA	cysteine--tRNA ligase	M1PG92	Moumouvirus	2.3e-45	30.5
WP_016179424.1\|165778_166177_+	Mini-ribonuclease 3	NA	NA	NA	NA
WP_016179425.1\|166166_166997_+	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_016179426.1\|166996_167524_+	NYN domain-containing protein	NA	NA	NA	NA
WP_016179427.1\|167593_168151_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_010782106.1\|168256_168502_+	veg family protein	NA	NA	NA	NA
WP_016179428.1\|168530_168977_-	large conductance mechanosensitive channel protein MscL	NA	NA	NA	NA
WP_137438880.1\|169386_170649_+	insulinase family protein	A0A1X9I714	Streptococcus_phage	2.6e-64	34.0
WP_137438881.1\|170641_171940_+	insulinase family protein	M1NN74	Moumouvirus	2.7e-16	24.0
WP_127978137.1\|171968_172694_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_137438882.1\|172819_173683_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016179433.1\|173717_174299_+	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_048719424.1\|174422_175670_+	competence/damage-inducible protein A	NA	NA	NA	NA
WP_016179435.1\|175794_176844_+	recombinase RecA	A0A0S2MVG1	Bacillus_phage	2.4e-127	67.2
WP_137438883.1\|177097_178654_+	ribonuclease Y	NA	NA	NA	NA
WP_070621753.1\|178733_179870_-\|integrase	site-specific integrase	A0A1S5S7K9	Streptococcus_phage	3.5e-68	38.4
WP_070621750.1\|179900_180215_-	hypothetical protein	NA	NA	NA	NA
WP_028020939.1\|180284_180713_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_028020938.1\|180728_181142_-	helix-turn-helix transcriptional regulator	A0A0M4QX29	Bacillus_phage	7.3e-32	52.2
WP_028020937.1\|181375_181582_+	helix-turn-helix transcriptional regulator	A0A1S5SDM7	Streptococcus_phage	2.0e-06	43.3
WP_137438884.1\|181584_181890_+	hypothetical protein	NA	NA	NA	NA
WP_137438885.1\|182027_183278_-\|transposase	IS110 family transposase	M1NSC9	Streptococcus_phage	2.3e-108	62.1
WP_118368284.1\|183684_183867_+	hypothetical protein	NA	NA	NA	NA
WP_118368283.1\|183859_184099_-	hypothetical protein	Q4ZC34	Staphylococcus_virus	5.5e-24	59.7
WP_118368282.1\|184319_184544_-	hypothetical protein	NA	NA	NA	NA
WP_118368281.1\|184596_185310_+	phage regulatory protein	D2IYT0	Enterococcus_phage	1.9e-67	57.0
WP_118368280.1\|185325_185526_+	hypothetical protein	NA	NA	NA	NA
WP_070509291.1\|185546_185810_+	hypothetical protein	NA	NA	NA	NA
WP_070509295.1\|185799_186009_-	hypothetical protein	NA	NA	NA	NA
WP_102865896.1\|186086_186278_+	hypothetical protein	NA	NA	NA	NA
WP_118368279.1\|186343_186757_+	hypothetical protein	NA	NA	NA	NA
WP_070509299.1\|186769_187513_+	hypothetical protein	A0A141E1K8	Streptococcus_phage	1.3e-47	42.1
WP_048720578.1\|187586_187916_+	hypothetical protein	NA	NA	NA	NA
WP_048720576.1\|188021_188963_+	endonuclease	D2IZK1	Enterococcus_phage	6.2e-119	65.4
WP_048720574.1\|188964_189813_+	phage RecT family recombinase	D2IYT9	Enterococcus_phage	6.9e-93	62.4
WP_048720572.1\|189852_190791_+	DUF4373 domain-containing protein	D2IZR2	Enterococcus_phage	1.5e-61	46.7
WP_028020901.1\|190795_191080_+	hypothetical protein	NA	NA	NA	NA
WP_010743600.1\|191076_191433_+	hypothetical protein	NA	NA	NA	NA
WP_028020902.1\|191804_192068_+	hypothetical protein	F8WQ63	Bacillus_phage	3.6e-08	42.2
WP_010746224.1\|192114_192558_-	hypothetical protein	A3F671	Streptococcus_phage	5.9e-19	37.0
WP_010746225.1\|192550_192808_-	hypothetical protein	NA	NA	NA	NA
WP_083303579.1\|192822_193020_-	hypothetical protein	NA	NA	NA	NA
WP_118368346.1\|193345_193813_+	hypothetical protein	C9E2P0	Enterococcus_phage	7.2e-68	78.3
WP_118368345.1\|193836_194067_+	hypothetical protein	NA	NA	NA	NA
WP_028020878.1\|194063_194402_+	hypothetical protein	A0A0B5A0A5	Streptococcus_phage	1.1e-06	60.9
WP_070504224.1\|194442_194625_+	hypothetical protein	NA	NA	NA	NA
WP_070509400.1\|194655_195606_+\|integrase	site-specific integrase	A8ATM2	Listeria_phage	1.6e-130	72.8
WP_028020911.1\|195620_196148_+	hypothetical protein	A8ATM3	Listeria_phage	1.3e-25	50.7
WP_028020912.1\|196122_196716_+	SAM-dependent DNA methyltransferase	L0P368	Streptococcus_phage	4.4e-46	44.7
WP_118368342.1\|196789_197275_+	hypothetical protein	A0A0C5JZC6	Enterococcus_phage	5.6e-23	48.7
WP_118368341.1\|197284_197464_+	hypothetical protein	NA	NA	NA	NA
WP_167494423.1\|197460_197628_+	hypothetical protein	NA	NA	NA	NA
WP_158408716.1\|197624_197798_+	hypothetical protein	NA	NA	NA	NA
WP_028020438.1\|198809_199289_+	hypothetical protein	A0A288WG73	Bacillus_phage	1.3e-24	45.6
WP_070503332.1\|200538_200796_+	hypothetical protein	NA	NA	NA	NA
WP_028020437.1\|200821_201691_+\|terminase	small subunit of terminase	D2IZ90	Enterococcus_phage	6.2e-65	51.8
WP_028020436.1\|201698_202967_+\|terminase	PBSX family phage terminase large subunit	V5UTH5	Oenococcus_phage	4.8e-175	71.2
202066:202082	attR	NA	NA	NA	NA
WP_028020435.1\|202983_204402_+\|portal	phage portal protein	D2J002	Enterococcus_phage	2.0e-201	74.5
WP_010743592.1\|204373_204850_+\|protease	ribosomal-processing cysteine protease Prp	A0A182BQ95	Lactococcus_phage	5.2e-13	43.6
WP_010743591.1\|204830_206069_+\|capsid	minor capsid protein	D2J004	Enterococcus_phage	2.1e-135	63.2
WP_010743590.1\|206212_206869_+	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_028020434.1\|206901_207921_+	hypothetical protein	D2J006	Enterococcus_phage	6.2e-165	86.4
WP_010743588.1\|207936_208284_+	hypothetical protein	D2J007	Enterococcus_phage	3.0e-34	66.1
WP_010743587.1\|208264_208618_+	hypothetical protein	D2J008	Enterococcus_phage	3.9e-34	63.4
WP_028020433.1\|208607_209147_+	hypothetical protein	D2J009	Enterococcus_phage	2.1e-55	56.4
WP_010743585.1\|209143_209509_+	hypothetical protein	NA	NA	NA	NA
WP_010743584.1\|209524_209962_+	hypothetical protein	Q6SE73	Lactobacillus_prophage	2.1e-21	40.0
WP_028020432.1\|210033_210405_+	hypothetical protein	D7RWJ8	Brochothrix_phage	7.1e-18	41.5
WP_010743582.1\|210437_210785_+	hypothetical protein	D2J013	Enterococcus_phage	9.5e-17	41.2
WP_137438886.1\|210788_215429_+	hypothetical protein	D2J014	Enterococcus_phage	3.6e-151	44.1
WP_010743580.1\|215441_215801_+	hypothetical protein	D7RWK1	Brochothrix_phage	1.7e-32	56.1
WP_112132917.1\|216262_218278_+	hypothetical protein	A0A059NT86	Lactococcus_phage	2.8e-140	45.9
WP_002346915.1\|218531_219782_-\|transposase	IS110 family transposase	M1NSC9	Streptococcus_phage	6.1e-114	62.1
WP_010743577.1\|220177_221212_+	hypothetical protein	A0A182BQ81	Lactococcus_phage	1.9e-15	60.6
WP_048718317.1\|221318_221621_+	hypothetical protein	A0A0P0IZF9	Lactobacillus_phage	4.7e-12	51.6
WP_010743575.1\|221623_221893_+	hypothetical protein	NA	NA	NA	NA
WP_070505065.1\|222010_223024_+	hypothetical protein	A0A2D1GPD8	Lactobacillus_phage	5.1e-42	55.0
WP_010743572.1\|223492_224467_+	choloylglycine hydrolase family protein	M1HVK5	Paramecium_bursaria_Chlorella_virus	2.7e-24	32.6
WP_137438887.1\|225049_226390_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	2.5e-65	36.0

DBSCAN-SWA_2

1058818 : 1116550

Bacillus_phage(23.08%)

transposase,integrase

attL 1071858:1071873|attR 1118359:1118374

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002346915.1\|1058818_1060069_-\|transposase	IS110 family transposase	M1NSC9	Streptococcus_phage	6.1e-114	62.1
WP_070505183.1\|1060464_1061049_+	hypothetical protein	NA	NA	NA	NA
WP_070505182.1\|1061135_1061471_+	hypothetical protein	NA	NA	NA	NA
WP_070505181.1\|1061714_1063463_+	AAA family ATPase	NA	NA	NA	NA
WP_070505180.1\|1063463_1065005_+	ATP-dependent helicase	Q331U3	Clostridium_botulinum_C_phage	4.3e-08	26.0
WP_070505179.1\|1065390_1068378_+	type I restriction endonuclease subunit R	NA	NA	NA	NA
WP_070505178.1\|1068414_1070010_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	4.9e-100	41.2
WP_137439259.1\|1070002_1071184_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_070505177.1\|1071224_1072151_-\|integrase	site-specific integrase	A8ATM2	Listeria_phage	3.7e-84	50.0
1071858:1071873	attL	NA	NA	NA	NA
WP_137439260.1\|1072217_1073414_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_070505175.1\|1073542_1074373_+	PRD domain-containing protein	NA	NA	NA	NA
WP_070505174.1\|1074474_1076400_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_070505173.1\|1076400_1077384_+	ADP-ribosylglycohydrolase	NA	NA	NA	NA
WP_070505172.1\|1077542_1078274_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_070505171.1\|1078474_1079278_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_083291875.1\|1079249_1079702_+	hypothetical protein	NA	NA	NA	NA
WP_048718614.1\|1079698_1080190_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_048718615.1\|1080194_1080935_+	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_048718617.1\|1080939_1081755_+	PTS system mannose/fructose/sorbose family transporter subunit IID	NA	NA	NA	NA
WP_070505169.1\|1081774_1082941_+	mannitol-1-phosphate 5-dehydrogenase	NA	NA	NA	NA
WP_070505168.1\|1082937_1083579_+	dihydroxyacetone kinase subunit L	NA	NA	NA	NA
WP_070505167.1\|1083603_1084599_+	dihydroxyacetone kinase subunit DhaK	NA	NA	NA	NA
WP_048718622.1\|1084624_1085272_+	3-hexulose-6-phosphate synthase	NA	NA	NA	NA
WP_070505166.1\|1085273_1085834_+	6-phospho-3-hexuloisomerase	NA	NA	NA	NA
WP_102866653.1\|1085923_1086934_+	dihydroxyacetone kinase subunit DhaK	NA	NA	NA	NA
WP_070505164.1\|1086949_1087591_+	dihydroxyacetone kinase subunit L	NA	NA	NA	NA
WP_070505163.1\|1088089_1088602_-	hypothetical protein	NA	NA	NA	NA
WP_070505162.1\|1089054_1089285_+	hypothetical protein	NA	NA	NA	NA
WP_070505161.1\|1089298_1090732_+	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
WP_048721853.1\|1090916_1091222_-	hypothetical protein	NA	NA	NA	NA
WP_083291874.1\|1091397_1092273_-	thymidylate synthase	A0A288TXX0	Enterococcus_phage	6.7e-83	50.2
WP_070505160.1\|1093106_1093991_+	TSUP family transporter	NA	NA	NA	NA
WP_049221973.1\|1094013_1094328_+	pyrimidine/purine nucleoside phosphorylase	NA	NA	NA	NA
WP_070505159.1\|1094463_1095237_+	HAD family phosphatase	NA	NA	NA	NA
WP_070505158.1\|1095478_1096324_+	PRD domain-containing protein	NA	NA	NA	NA
WP_070505157.1\|1096316_1097738_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_070505156.1\|1097706_1098492_+	ChbG/HpnK family deacetylase	NA	NA	NA	NA
WP_070505155.1\|1098494_1098959_+	PTS glucose transporter subunit IIA	NA	NA	NA	NA
WP_070505154.1\|1099013_1100330_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	9.9e-22	30.7
WP_049221987.1\|1100334_1101009_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.3e-30	35.5
WP_070505153.1\|1101151_1102648_+	ABC transporter permease	NA	NA	NA	NA
WP_070505152.1\|1102701_1103361_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.2e-21	33.0
WP_070505151.1\|1103386_1105024_+	aryl-sulfate sulfotransferase	NA	NA	NA	NA
WP_102866650.1\|1105499_1106888_+	group II intron reverse transcriptase/maturase	H7BVW2	unidentified_phage	2.4e-10	26.4
WP_070504983.1\|1107123_1107438_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_070504984.1\|1107699_1108281_+	hypothetical protein	NA	NA	NA	NA
WP_070504985.1\|1108291_1109149_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_102866649.1\|1109403_1110651_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-32	40.3
WP_137440449.1\|1110736_1112116_-\|transposase	IS1182 family transposase	A0A1X9I5T2	Streptococcus_phage	2.5e-124	47.5
WP_070504585.1\|1112686_1112887_+	hypothetical protein	NA	NA	NA	NA
WP_137439262.1\|1112972_1113830_+	hypothetical protein	NA	NA	NA	NA
WP_102866649.1\|1113915_1115163_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-32	40.3
WP_083291837.1\|1116304_1116550_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A1P8CWQ3	Bacillus_phage	2.9e-12	49.4
1118359:1118374	attR	NA	NA	NA	NA

DBSCAN-SWA_3

1371123 : 1443364

Enterococcus_phage(38.89%)

tRNA,portal,capsid,terminase,transposase,integrase,protease

attL 1377032:1377047|attR 1422724:1422739

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_049218291.1\|1371123_1371612_+\|tRNA	prolyl-tRNA synthetase associated domain-containing protein	NA	NA	NA	NA
WP_049218289.1\|1371826_1372585_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.5e-27	29.3
WP_070503348.1\|1372577_1374176_+	ABC transporter	NA	NA	NA	NA
WP_016178287.1\|1374827_1376315_+	glutamate/gamma-aminobutyrate family transporter YjeM	NA	NA	NA	NA
WP_016178288.1\|1376358_1378611_-	ABC transporter permease	NA	NA	NA	NA
1377032:1377047	attL	NA	NA	NA	NA
WP_016178289.1\|1378610_1379312_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	7.6e-37	41.7
WP_016178290.1\|1379479_1380106_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_016178291.1\|1381014_1381587_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_016178292.1\|1381961_1382897_+	hypothetical protein	NA	NA	NA	NA
WP_016178293.1\|1383582_1384665_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	7.1e-119	61.9
WP_016178294.1\|1384665_1385853_+	hypothetical protein	M1NSB9	Streptococcus_phage	3.3e-117	53.3
WP_016178295.1\|1385852_1387079_+	DUF1015 domain-containing protein	NA	NA	NA	NA
WP_016178296.1\|1387186_1387522_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_016178297.1\|1387524_1388568_+	hypothetical protein	NA	NA	NA	NA
WP_070503346.1\|1388846_1389986_+\|transposase	IS200/IS605 family element transposase accessory protein TnpB	D9J0Y9	Brochothrix_phage	1.0e-163	73.3
WP_070503344.1\|1390225_1391326_+	hypothetical protein	NA	NA	NA	NA
WP_016178300.1\|1391447_1392602_+	PLP-dependent transferase	NA	NA	NA	NA
WP_016178301.1\|1392755_1393214_+	hypothetical protein	NA	NA	NA	NA
WP_016178302.1\|1393306_1395076_-	polysaccharide biosynthesis protein	NA	NA	NA	NA
WP_016178303.1\|1395153_1395849_-	TIGR00266 family protein	NA	NA	NA	NA
WP_049218556.1\|1395954_1396734_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.2e-13	25.7
WP_016178305.1\|1397045_1398746_-	M3 family oligoendopeptidase	NA	NA	NA	NA
WP_016178306.1\|1398826_1399963_-	alanine dehydrogenase	NA	NA	NA	NA
WP_016178307.1\|1400259_1400652_+	hypothetical protein	NA	NA	NA	NA
WP_016178308.1\|1400672_1402187_-	hypothetical protein	NA	NA	NA	NA
WP_070503342.1\|1402155_1403688_-	HTH domain-containing protein	NA	NA	NA	NA
WP_010743624.1\|1404014_1404290_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	8.9e-26	67.0
WP_028020498.1\|1404389_1405532_-\|integrase	site-specific integrase	A0A0S2MYI6	Enterococcus_phage	3.2e-77	42.4
WP_010743620.1\|1405642_1406449_-	potassium channel family protein	A0A1B0Y2S3	Lactobacillus_phage	1.8e-34	52.3
WP_010743619.1\|1406457_1406862_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
WP_010743618.1\|1406882_1407194_-	helix-turn-helix domain-containing protein	A0A1S5SDR1	Streptococcus_phage	2.7e-15	42.5
WP_010743617.1\|1407491_1407674_+	hypothetical protein	NA	NA	NA	NA
WP_010743616.1\|1407686_1407989_+	hypothetical protein	NA	NA	NA	NA
WP_010743615.1\|1407985_1408264_+	hypothetical protein	NA	NA	NA	NA
WP_028020495.1\|1408403_1409321_+	hypothetical protein	A0A286QNK1	Streptococcus_phage	7.6e-29	41.1
WP_028020494.1\|1409313_1409787_+	hypothetical protein	NA	NA	NA	NA
WP_010743612.1\|1409801_1409954_+	hypothetical protein	NA	NA	NA	NA
WP_158408717.1\|1409956_1410112_+	hypothetical protein	NA	NA	NA	NA
WP_082158552.1\|1410093_1410603_-	DUF4145 domain-containing protein	A0A1X9I5M7	Streptococcus_phage	4.1e-40	50.0
WP_167494427.1\|1410852_1410996_+	hypothetical protein	NA	NA	NA	NA
WP_070503338.1\|1411024_1411354_+	hypothetical protein	NA	NA	NA	NA
WP_048720576.1\|1411459_1412401_+	endonuclease	D2IZK1	Enterococcus_phage	6.2e-119	65.4
WP_048720574.1\|1412402_1413251_+	phage RecT family recombinase	D2IYT9	Enterococcus_phage	6.9e-93	62.4
WP_048720572.1\|1413290_1414229_+	DUF4373 domain-containing protein	D2IZR2	Enterococcus_phage	1.5e-61	46.7
WP_028020901.1\|1414233_1414518_+	hypothetical protein	NA	NA	NA	NA
WP_010743600.1\|1414514_1414871_+	hypothetical protein	NA	NA	NA	NA
WP_070503334.1\|1414870_1415179_+	hypothetical protein	D2IZY1	Enterococcus_phage	1.6e-28	58.6
WP_167494428.1\|1415340_1415508_+	hypothetical protein	NA	NA	NA	NA
WP_016178316.1\|1415560_1416079_-	hypothetical protein	NA	NA	NA	NA
WP_028020968.1\|1416693_1417080_+	hypothetical protein	NA	NA	NA	NA
WP_010743598.1\|1418171_1418651_+	hypothetical protein	A0A2H4JFW6	uncultured_Caudovirales_phage	7.7e-25	46.8
WP_010743597.1\|1419504_1419687_+	hypothetical protein	NA	NA	NA	NA
WP_010743596.1\|1420017_1420242_+	hypothetical protein	NA	NA	NA	NA
WP_010743595.1\|1420267_1420624_+	hypothetical protein	A0A0S2MYF8	Enterococcus_phage	1.4e-42	76.3
WP_010743594.1\|1420574_1421897_+\|terminase	PBSX family phage terminase large subunit	D2J001	Enterococcus_phage	1.1e-211	82.3
WP_010743593.1\|1421914_1423333_+\|portal	phage portal protein	D2J002	Enterococcus_phage	1.8e-202	74.7
1422724:1422739	attR	NA	NA	NA	NA
WP_010743592.1\|1423304_1423781_+\|protease	ribosomal-processing cysteine protease Prp	A0A182BQ95	Lactococcus_phage	5.2e-13	43.6
WP_010743591.1\|1423761_1425000_+\|capsid	minor capsid protein	D2J004	Enterococcus_phage	2.1e-135	63.2
WP_010743590.1\|1425143_1425800_+	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_028020434.1\|1425832_1426852_+	hypothetical protein	D2J006	Enterococcus_phage	6.2e-165	86.4
WP_010743588.1\|1426867_1427215_+	hypothetical protein	D2J007	Enterococcus_phage	3.0e-34	66.1
WP_010743587.1\|1427195_1427549_+	hypothetical protein	D2J008	Enterococcus_phage	3.9e-34	63.4
WP_028020433.1\|1427538_1428078_+	hypothetical protein	D2J009	Enterococcus_phage	2.1e-55	56.4
WP_010743585.1\|1428074_1428440_+	hypothetical protein	NA	NA	NA	NA
WP_010743584.1\|1428455_1428893_+	hypothetical protein	Q6SE73	Lactobacillus_prophage	2.1e-21	40.0
WP_028020432.1\|1428964_1429336_+	hypothetical protein	D7RWJ8	Brochothrix_phage	7.1e-18	41.5
WP_010743582.1\|1429368_1429716_+	hypothetical protein	D2J013	Enterococcus_phage	9.5e-17	41.2
WP_002297293.1\|1432222_1433410_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	4.6e-26	28.7
WP_137439281.1\|1435992_1436352_+	hypothetical protein	A0A059NT91	Lactococcus_phage	7.5e-33	61.1
WP_137439282.1\|1436363_1438985_+	hypothetical protein	A0A182BQ83	Lactococcus_phage	5.8e-207	51.5
WP_167494429.1\|1438985_1439138_+	hypothetical protein	NA	NA	NA	NA
WP_049218645.1\|1439138_1440173_+	hypothetical protein	A0A182BQ81	Lactococcus_phage	1.6e-14	59.2
WP_048718317.1\|1440279_1440582_+	hypothetical protein	A0A0P0IZF9	Lactobacillus_phage	4.7e-12	51.6
WP_016178333.1\|1440584_1440854_+	hypothetical protein	NA	NA	NA	NA
WP_137439284.1\|1440971_1441985_+	hypothetical protein	A0A2D1GPD8	Lactobacillus_phage	2.1e-43	55.2
WP_118368306.1\|1442788_1443364_-	SHOCT domain-containing protein	X5JB37	Clostridium_phage	3.9e-15	33.6

DBSCAN-SWA_4

1905815 : 1971575

Streptococcus_phage(27.5%)

holin,head,tail,portal,capsid,terminase,transposase,integrase,protease

attL 1905710:1905740|attR 1949319:1949349

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1905710:1905740	attL	NA	NA	NA	NA
WP_137439613.1\|1905815_1906952_-\|integrase	site-specific integrase	A0A0S2MYI6	Enterococcus_phage	1.0e-136	65.3
WP_137439615.1\|1907026_1907641_-	DUF4352 domain-containing protein	NA	NA	NA	NA
WP_137439617.1\|1907655_1908294_-	helix-turn-helix domain-containing protein	A0A2H4J245	uncultured_Caudovirales_phage	3.9e-24	35.7
WP_137439619.1\|1908449_1908680_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_137439620.1\|1908853_1909099_+	hypothetical protein	A0A0S2MYC6	Enterococcus_phage	3.0e-17	53.8
WP_137439622.1\|1909112_1909811_+	hypothetical protein	D2IZW4	Enterococcus_phage	9.4e-56	52.3
WP_137439623.1\|1909821_1910013_+	hypothetical protein	NA	NA	NA	NA
WP_137440460.1\|1910045_1910516_-	hypothetical protein	NA	NA	NA	NA
WP_167494433.1\|1910605_1910752_+	hypothetical protein	NA	NA	NA	NA
WP_137439625.1\|1910787_1911015_+	hypothetical protein	NA	NA	NA	NA
WP_137439627.1\|1911027_1911564_+	hypothetical protein	A0A0A7S0G6	Clostridium_phage	3.1e-22	38.5
WP_137439629.1\|1911565_1912564_+	AAA family ATPase	A0A0S2SY47	Bacillus_phage	6.7e-63	44.1
WP_137439631.1\|1912569_1913238_+	hypothetical protein	C9E2N1	Enterococcus_phage	2.6e-55	47.1
WP_137439633.1\|1914177_1914594_+	RusA family crossover junction endodeoxyribonuclease	D2IYU2	Enterococcus_phage	1.0e-33	53.6
WP_137439634.1\|1914590_1915028_+	single-stranded DNA-binding protein	A0A097PAQ3	Streptococcus_pyogenes_phage	1.2e-45	69.2
WP_137439636.1\|1915038_1915527_+	hypothetical protein	NA	NA	NA	NA
WP_048722687.1\|1915528_1915771_+	hypothetical protein	NA	NA	NA	NA
WP_137439637.1\|1915829_1916051_+	hypothetical protein	NA	NA	NA	NA
WP_158408725.1\|1916098_1916263_+	hypothetical protein	NA	NA	NA	NA
WP_158408726.1\|1916330_1916546_+	DUF1642 domain-containing protein	NA	NA	NA	NA
WP_158408727.1\|1916564_1916732_+	hypothetical protein	NA	NA	NA	NA
WP_137439641.1\|1916764_1917073_+	hypothetical protein	F0PIH6	Enterococcus_phage	6.5e-33	62.7
WP_070558084.1\|1917109_1917346_+	hypothetical protein	NA	NA	NA	NA
WP_158408728.1\|1917357_1917525_+	hypothetical protein	NA	NA	NA	NA
WP_102865907.1\|1917521_1917833_+	replicase	NA	NA	NA	NA
WP_158408729.1\|1917829_1917985_+	hypothetical protein	NA	NA	NA	NA
WP_070504224.1\|1918025_1918208_+	hypothetical protein	NA	NA	NA	NA
WP_070509400.1\|1918238_1919189_+\|integrase	site-specific integrase	A8ATM2	Listeria_phage	1.6e-130	72.8
WP_028020911.1\|1919203_1919731_+	hypothetical protein	A8ATM3	Listeria_phage	1.3e-25	50.7
WP_028020912.1\|1919705_1920299_+	SAM-dependent DNA methyltransferase	L0P368	Streptococcus_phage	4.4e-46	44.7
WP_137439643.1\|1920331_1920919_+	DUF1642 domain-containing protein	E8ZD53	Streptococcus_phage	7.5e-06	29.0
WP_137439645.1\|1920927_1921317_+	hypothetical protein	NA	NA	NA	NA
WP_137439647.1\|1921313_1921577_+	hypothetical protein	NA	NA	NA	NA
WP_070621694.1\|1921573_1921753_+	hypothetical protein	NA	NA	NA	NA
WP_137439649.1\|1922010_1922400_+	hypothetical protein	J7KJ21	Streptococcus_phage	1.4e-13	40.1
WP_048719862.1\|1922400_1922706_+	hypothetical protein	D2IZR3	Enterococcus_phage	9.6e-21	50.0
WP_158408730.1\|1922837_1923287_+	hypothetical protein	NA	NA	NA	NA
WP_158408731.1\|1923891_1924059_+	hypothetical protein	NA	NA	NA	NA
WP_010743339.1\|1924145_1924304_+	hypothetical protein	NA	NA	NA	NA
WP_167494434.1\|1924454_1924631_+	hypothetical protein	NA	NA	NA	NA
WP_137439655.1\|1924636_1924840_+	hypothetical protein	NA	NA	NA	NA
WP_137439656.1\|1924836_1925025_+	hypothetical protein	NA	NA	NA	NA
WP_137439658.1\|1925583_1925895_+	HNH endonuclease	A0A1S5SFB3	Streptococcus_phage	8.0e-31	62.1
WP_137440461.1\|1925984_1926191_+	hypothetical protein	NA	NA	NA	NA
WP_137439660.1\|1926314_1926674_+	hypothetical protein	A0A2H4JAH7	uncultured_Caudovirales_phage	1.6e-30	68.6
WP_137439661.1\|1926670_1928314_+\|terminase	terminase large subunit	A0A1S5SF58	Streptococcus_phage	2.0e-213	66.0
WP_137439663.1\|1928339_1929494_+\|portal	phage portal protein	A0A1S5SFG8	Streptococcus_phage	5.3e-104	51.7
WP_010722457.1\|1929474_1930182_+\|protease	Clp protease ClpP	A0A1S5SFF8	Streptococcus_phage	4.0e-70	61.2
WP_137439665.1\|1930208_1931345_+\|capsid	phage major capsid protein	A0A1W6JPL4	Staphylococcus_phage	1.4e-136	65.2
WP_002342053.1\|1931352_1931496_+	hypothetical protein	A0A059T7Y2	Listeria_phage	2.1e-07	56.5
WP_137439666.1\|1931508_1931796_+\|head,tail	phage gp6-like head-tail connector protein	A0A1S5SF81	Streptococcus_phage	4.6e-17	51.1
WP_104771611.1\|1931776_1932157_+\|head,tail	phage head-tail adapter protein	A8ATA1	Listeria_phage	1.2e-33	60.7
WP_137439667.1\|1932149_1932554_+	hypothetical protein	A0A059T5F3	Listeria_phage	3.1e-19	39.4
WP_137439668.1\|1932550_1932961_+	hypothetical protein	A0A059T681	Listeria_phage	1.2e-23	49.6
WP_137439669.1\|1933025_1933622_+\|tail	phage tail protein	A0A2P0ZLF5	Lactobacillus_phage	6.6e-34	42.4
WP_137439670.1\|1933682_1933994_+	hypothetical protein	NA	NA	NA	NA
WP_137439671.1\|1934188_1940401_+\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	5.2e-113	33.8
WP_137439672.1\|1940401_1941223_+\|tail	phage tail family protein	Q9T1A6	Listeria_phage	1.0e-45	39.0
WP_137439673.1\|1941231_1942257_+	hypothetical protein	Q9T1A5	Listeria_phage	7.0e-100	51.5
WP_137439674.1\|1942256_1943306_+	hypothetical protein	A0A059T661	Listeria_phage	1.8e-21	34.4
WP_137439675.1\|1945986_1946337_+	hypothetical protein	NA	NA	NA	NA
WP_016180074.1\|1946669_1946912_+\|holin	phage holin	D2J075	Enterococcus_phage	5.2e-22	63.3
WP_010746270.1\|1946923_1947121_+\|holin	holin	A0A0S2MYF6	Enterococcus_phage	2.5e-22	84.4
WP_137439676.1\|1947131_1948241_+	endolysin	A0A0S2MYF3	Enterococcus_phage	1.4e-101	75.1
WP_070621288.1\|1948287_1948542_-	hypothetical protein	NA	NA	NA	NA
WP_137439677.1\|1948722_1949121_-	hypothetical protein	NA	NA	NA	NA
WP_048720345.1\|1949517_1950387_+	SPFH domain-containing protein	NA	NA	NA	NA
1949319:1949349	attR	NA	NA	NA	NA
WP_048720343.1\|1950398_1950893_+	hypothetical protein	NA	NA	NA	NA
WP_048720347.1\|1950944_1951424_-	methylated-DNA--[protein]-cysteine S-methyltransferase	A0A0G2Y1B6	Acanthamoeba_polyphaga_mimivirus	3.2e-15	50.0
WP_016179817.1\|1951520_1952900_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_016179818.1\|1952934_1953555_+	YutD family protein	NA	NA	NA	NA
WP_016179819.1\|1953559_1954330_+	TIGR01457 family HAD-type hydrolase	NA	NA	NA	NA
WP_137439678.1\|1954319_1954955_+	TIGR01906 family membrane protein	NA	NA	NA	NA
WP_016179821.1\|1954974_1955484_-	phosphatidylglycerophosphatase A	G3MBC5	Bacillus_virus	2.3e-43	56.4
WP_137439679.1\|1955543_1956527_-	NAD(P)/FAD-dependent oxidoreductase	Q9JRK7	Streptococcus_phage	1.5e-30	54.0
WP_049218898.1\|1956658_1957246_+	peptidylprolyl isomerase	A0A2H4UTF4	Bodo_saltans_virus	2.1e-24	41.0
WP_137439680.1\|1957305_1958472_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_016179825.1\|1958549_1958930_+	S1 RNA-binding domain-containing protein	NA	NA	NA	NA
WP_016252545.1\|1959018_1959378_+	hypothetical protein	NA	NA	NA	NA
WP_137439681.1\|1970300_1971575_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.7e-55	36.4

DBSCAN-SWA_5

3124896 : 3133983

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_137439949.1\|3124896_3125478_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	8.2e-29	36.5
WP_137439950.1\|3125474_3126518_-	phosphoribosylformylglycinamidine cyclo-ligase	M4QRQ6	Synechococcus_phage	1.7e-61	41.1
WP_016180331.1\|3126715_3128155_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.7e-57	34.6
WP_137439951.1\|3128139_3130359_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.8e-148	39.6
WP_127979038.1\|3130358_3131039_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_016180334.1\|3131040_3131295_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_137439952.1\|3131297_3132014_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3G7P8	Synechococcus_phage	8.5e-44	40.2
WP_016180336.1\|3132151_3132643_+	hypothetical protein	NA	NA	NA	NA
WP_137439953.1\|3132687_3133983_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	3.5e-19	32.1

DBSCAN-SWA_6

3250503 : 3334562

Enterococcus_phage(33.33%)

holin,portal,capsid,plate,transposase,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002297293.1\|3250503_3251691_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	4.6e-26	28.7
WP_016182176.1\|3258840_3260346_-	HAMP domain-containing histidine kinase	Q8QNA2	Ectocarpus_siliculosus_virus	1.1e-08	30.8
WP_010740068.1\|3260342_3261029_-	response regulator transcription factor	W8CYM9	Bacillus_phage	1.3e-28	31.7
WP_137439972.1\|3261136_3262558_-	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	2.0e-44	30.0
WP_010740070.1\|3262894_3263074_-	50S ribosomal protein L32	NA	NA	NA	NA
WP_016182174.1\|3263133_3263688_-	hypothetical protein	NA	NA	NA	NA
WP_016182173.1\|3263972_3265757_-	pyruvate kinase	NA	NA	NA	NA
WP_016182172.1\|3265826_3266789_-	6-phosphofructokinase	NA	NA	NA	NA
WP_137439973.1\|3266929_3270187_-	DNA polymerase III subunit alpha	A0A2L1IZ23	Streptomyces_phage	3.1e-149	32.6
WP_016182170.1\|3270387_3270567_+	YjzD family protein	NA	NA	NA	NA
WP_102871128.1\|3271210_3272011_-	zf-TFIIB domain-containing protein	NA	NA	NA	NA
WP_102871127.1\|3272287_3272938_-	hypothetical protein	NA	NA	NA	NA
WP_016182167.1\|3273214_3274417_-	multidrug efflux MFS transporter	NA	NA	NA	NA
WP_016182166.1\|3274698_3275505_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_102871126.1\|3275701_3276484_-	DUF4357 domain-containing protein	NA	NA	NA	NA
WP_102871125.1\|3276664_3277342_-	DUF2922 family protein	NA	NA	NA	NA
WP_102871124.1\|3277405_3277789_-	hypothetical protein	NA	NA	NA	NA
WP_016182162.1\|3278489_3278717_-	hypothetical protein	NA	NA	NA	NA
WP_102871123.1\|3279137_3279914_+	hypothetical protein	NA	NA	NA	NA
WP_016182160.1\|3280314_3280887_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_102871122.1\|3281278_3282031_+	threonine/serine exporter family protein	NA	NA	NA	NA
WP_016182158.1\|3282057_3282507_+	threonine/serine exporter	NA	NA	NA	NA
WP_016182157.1\|3282695_3283292_+	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	1.2e-30	38.9
WP_102871121.1\|3283606_3285175_+	hypothetical protein	NA	NA	NA	NA
WP_102871120.1\|3285223_3286024_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_016182153.1\|3287221_3287449_-	hypothetical protein	NA	NA	NA	NA
WP_137439974.1\|3287975_3288161_-	hypothetical protein	NA	NA	NA	NA
WP_010746282.1\|3288258_3288492_+	hypothetical protein	NA	NA	NA	NA
WP_137439976.1\|3288496_3288940_+	hypothetical protein	NA	NA	NA	NA
WP_010746278.1\|3290339_3290744_+	hypothetical protein	NA	NA	NA	NA
WP_127978912.1\|3290725_3291046_+	hypothetical protein	NA	NA	NA	NA
WP_010746276.1\|3291047_3291638_+	DUF159 family protein	NA	NA	NA	NA
WP_010746275.1\|3291652_3291865_+	hypothetical protein	NA	NA	NA	NA
WP_137439977.1\|3291836_3292091_+	hypothetical protein	NA	NA	NA	NA
WP_016180076.1\|3293285_3293813_+	hypothetical protein	NA	NA	NA	NA
WP_016180075.1\|3293979_3294987_-	N-acetylmuramoyl-L-alanine amidase	A0A1G5SA77	Enterococcus_phage	4.9e-53	59.8
WP_010746270.1\|3294997_3295195_-\|holin	holin	A0A0S2MYF6	Enterococcus_phage	2.5e-22	84.4
WP_016180074.1\|3295206_3295449_-\|holin	phage holin	D2J075	Enterococcus_phage	5.2e-22	63.3
WP_010746266.1\|3295781_3296132_-	hypothetical protein	NA	NA	NA	NA
WP_137439978.1\|3298506_3299286_-	hypothetical protein	NA	NA	NA	NA
WP_010746263.1\|3299297_3300347_-	hypothetical protein	NA	NA	NA	NA
WP_010746262.1\|3300343_3301222_-\|plate	phage baseplate protein	D3W0E8	Lactococcus_phage	3.6e-28	30.1
WP_137439979.1\|3301223_3307721_-	tape measure protein	A0A060ANI0	Enterococcus_phage	1.8e-84	38.8
WP_016180071.1\|3307748_3308012_-	hypothetical protein	NA	NA	NA	NA
WP_010746257.1\|3308065_3308644_-	hypothetical protein	NA	NA	NA	NA
WP_010746256.1\|3308700_3309519_-	hypothetical protein	NA	NA	NA	NA
WP_010746255.1\|3309518_3309773_-	hypothetical protein	NA	NA	NA	NA
WP_137439980.1\|3309785_3310139_-	hypothetical protein	NA	NA	NA	NA
WP_010746253.1\|3310153_3310579_-	hypothetical protein	NA	NA	NA	NA
WP_070503261.1\|3310580_3310940_-	hypothetical protein	NA	NA	NA	NA
WP_010746251.1\|3310929_3311337_-	hypothetical protein	A5GYM1	Lactococcus_phage	3.1e-27	48.1
WP_137439981.1\|3311346_3311667_-	hypothetical protein	NA	NA	NA	NA
WP_010746249.1\|3311680_3312631_-\|capsid	phage major capsid protein	A0A1B1P7E3	Bacillus_phage	3.8e-100	62.3
WP_137439982.1\|3312630_3313719_-	DNA methyltransferase	A5GYL8	Lactococcus_phage	8.5e-112	75.7
WP_167494438.1\|3313762_3313936_-	hypothetical protein	NA	NA	NA	NA
WP_010746246.1\|3314069_3314936_-	hypothetical protein	NA	NA	NA	NA
WP_010746245.1\|3314937_3316461_-\|portal	phage portal protein	A5GYL6	Lactococcus_phage	1.2e-177	62.2
WP_010746244.1\|3316471_3317920_-\|terminase	phage terminase large subunit	A5GYP8	Lactococcus_phage	1.5e-228	79.2
WP_010746243.1\|3317903_3318326_-	hypothetical protein	Q9AZ67	Lactococcus_phage	1.2e-45	72.1
WP_010746242.1\|3318372_3318795_-	hypothetical protein	NA	NA	NA	NA
WP_137440476.1\|3319190_3319604_-	autolysin	C9E2P5	Enterococcus_phage	2.1e-47	64.2
WP_010746240.1\|3319866_3320067_-	hypothetical protein	NA	NA	NA	NA
WP_010746239.1\|3320108_3320297_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_137439983.1\|3320320_3320665_-	hypothetical protein	NA	NA	NA	NA
WP_137439984.1\|3320686_3321055_-	hypothetical protein	NA	NA	NA	NA
WP_137439985.1\|3321051_3321534_-	hypothetical protein	Q938M1	Temperate_phage	4.0e-13	40.4
WP_137439986.1\|3321880_3322147_-	hypothetical protein	NA	NA	NA	NA
WP_137439987.1\|3322320_3322869_-	DUF1642 domain-containing protein	A0A141E0T9	Streptococcus_phage	8.9e-09	32.9
WP_016180840.1\|3323187_3323424_+	hypothetical protein	NA	NA	NA	NA
WP_137439988.1\|3323480_3323705_-	hypothetical protein	A0A0S2MYD2	Enterococcus_phage	4.9e-14	57.1
WP_137439989.1\|3323701_3323932_-	hypothetical protein	NA	NA	NA	NA
WP_070509270.1\|3323970_3324150_-	hypothetical protein	NA	NA	NA	NA
WP_070509272.1\|3324178_3324502_-	hypothetical protein	NA	NA	NA	NA
WP_137439990.1\|3324537_3324864_-	hypothetical protein	NA	NA	NA	NA
WP_083284959.1\|3325233_3325431_+	hypothetical protein	NA	NA	NA	NA
WP_010746225.1\|3325445_3325703_+	hypothetical protein	NA	NA	NA	NA
WP_010746224.1\|3325695_3326139_+	hypothetical protein	A3F671	Streptococcus_phage	5.9e-19	37.0
WP_016180046.1\|3326173_3326485_-	hypothetical protein	D2IZR4	Enterococcus_phage	5.2e-30	63.6
WP_010746220.1\|3327522_3327726_-	hypothetical protein	NA	NA	NA	NA
WP_016180044.1\|3327728_3328019_-	hypothetical protein	NA	NA	NA	NA
WP_010746218.1\|3328005_3328266_-	hypothetical protein	D2XR36	Bacillus_phage	9.7e-06	35.9
WP_016180043.1\|3328262_3328673_-	DUF1064 domain-containing protein	A0A1P8BKR1	Lactococcus_phage	3.0e-09	34.2
WP_137439991.1\|3328669_3328933_-	hypothetical protein	NA	NA	NA	NA
WP_137439992.1\|3328910_3329864_-	DUF4373 domain-containing protein	D2IZY0	Enterococcus_phage	2.1e-58	51.2
WP_137439993.1\|3329907_3330837_-	recombinase RecT	D2IYT9	Enterococcus_phage	4.1e-99	65.1
WP_010746213.1\|3330838_3331780_-	hypothetical protein	D2IZK1	Enterococcus_phage	1.8e-118	64.1
WP_070504296.1\|3331964_3332162_-	hypothetical protein	NA	NA	NA	NA
WP_070504299.1\|3332158_3332437_-	hypothetical protein	NA	NA	NA	NA
WP_137439994.1\|3332439_3332973_-	hypothetical protein	NA	NA	NA	NA
WP_167494439.1\|3333157_3333322_-	hypothetical protein	NA	NA	NA	NA
WP_070504306.1\|3333321_3333573_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_070504309.1\|3333726_3334065_+	helix-turn-helix transcriptional regulator	S6C481	Thermus_phage	4.2e-09	47.3
WP_137439995.1\|3334094_3334562_+	ImmA/IrrE family metallo-endopeptidase	A0A1W6JPB4	Staphylococcus_phage	9.2e-15	32.3

DBSCAN-SWA_7

3393100 : 3451515

Bacillus_phage(22.22%)

transposase,integrase

attL 3426376:3426392|attR 3454813:3454829

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_048720069.1\|3393100_3394309_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	2.2e-23	23.9
WP_137440014.1\|3395262_3396453_-	MFS transporter	NA	NA	NA	NA
WP_016182101.1\|3396615_3397506_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_016182100.1\|3397583_3398081_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_016182099.1\|3398286_3399261_+	serine hydrolase	NA	NA	NA	NA
WP_016182098.1\|3399428_3399968_-	DUF1697 domain-containing protein	NA	NA	NA	NA
WP_167494440.1\|3399977_3400730_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_016182096.1\|3400845_3401265_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_016182095.1\|3401682_3402324_+	DUF3796 domain-containing protein	NA	NA	NA	NA
WP_016182094.1\|3402327_3402531_+	helix-turn-helix transcriptional regulator	A0A1V0E021	Clostridioides_phage	4.4e-06	49.2
WP_016182093.1\|3402740_3403037_+	hypothetical protein	NA	NA	NA	NA
WP_016182091.1\|3403060_3403552_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_016182090.1\|3403569_3404301_-	hypothetical protein	NA	NA	NA	NA
WP_016182089.1\|3404485_3405961_+	hypothetical protein	NA	NA	NA	NA
WP_137440015.1\|3406013_3407060_-	BtrH N-terminal domain-containing protein	NA	NA	NA	NA
WP_016182086.1\|3407123_3407945_-	MerR family transcriptional regulator	NA	NA	NA	NA
WP_034876421.1\|3408107_3408479_+	hypothetical protein	NA	NA	NA	NA
WP_016182084.1\|3408504_3409101_+	PadR family transcriptional regulator	NA	NA	NA	NA
WP_016182083.1\|3409193_3409883_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_016182082.1\|3410106_3411330_+	cysteine desulfurase-like protein	A0A2K9L2Y3	Tupanvirus	8.0e-26	26.3
WP_016182081.1\|3411345_3412086_+	cyclase family protein	NA	NA	NA	NA
WP_016182080.1\|3412124_3412589_-	hypothetical protein	NA	NA	NA	NA
WP_016182079.1\|3412690_3413278_-	DJ-1/PfpI family protein	NA	NA	NA	NA
WP_016182078.1\|3413422_3413839_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_016182077.1\|3413884_3415225_-	ribosome small subunit-dependent GTPase A	NA	NA	NA	NA
WP_016182076.1\|3415631_3415958_-	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_016182075.1\|3416069_3416450_-	hypothetical protein	NA	NA	NA	NA
WP_016182074.1\|3416439_3417420_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_137440016.1\|3417539_3418208_-	hypothetical protein	NA	NA	NA	NA
WP_016182072.1\|3418424_3419510_-	hypothetical protein	NA	NA	NA	NA
WP_016182071.1\|3420013_3420517_+	NAD(P)H-dependent oxidoreductase subunit E	NA	NA	NA	NA
WP_002297293.1\|3420841_3422029_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	4.6e-26	28.7
WP_137440478.1\|3422307_3424128_+	NADH-quinone oxidoreductase subunit NuoF	NA	NA	NA	NA
WP_137440017.1\|3424140_3425889_+	2Fe-2S iron-sulfur cluster binding domain-containing protein	NA	NA	NA	NA
WP_016182068.1\|3425986_3426685_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
3426376:3426392	attL	NA	NA	NA	NA
WP_016182067.1\|3427005_3428553_-	hypothetical protein	NA	NA	NA	NA
WP_137440018.1\|3429004_3430549_+	hypothetical protein	NA	NA	NA	NA
WP_016182065.1\|3430651_3431197_-	hypothetical protein	NA	NA	NA	NA
WP_016182064.1\|3431528_3432134_+	DUF1349 domain-containing protein	NA	NA	NA	NA
WP_137440019.1\|3432356_3433535_-\|integrase	site-specific integrase	S6C485	Thermus_phage	6.1e-31	31.1
WP_016182062.1\|3433639_3433948_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_028021252.1\|3434383_3434626_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016182060.1\|3434612_3435041_-	DNA-directed RNA polymerase sigma-70 factor	NA	NA	NA	NA
WP_016182059.1\|3435758_3435875_-	hypothetical protein	NA	NA	NA	NA
WP_016182058.1\|3435902_3437078_-	SIS domain-containing protein	NA	NA	NA	NA
WP_016182057.1\|3437093_3438104_-	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_016182056.1\|3438123_3439497_-	hypothetical protein	NA	NA	NA	NA
WP_137440020.1\|3439508_3439787_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_016182054.1\|3439803_3440262_-	PTS sugar transporter subunit IIA	NA	NA	NA	NA
WP_071875980.1\|3440288_3440684_-	PTS transporter subunit EIIA	NA	NA	NA	NA
WP_016182052.1\|3440839_3442861_-	BglG family transcription antiterminator	NA	NA	NA	NA
WP_016182050.1\|3444174_3444888_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_099434174.1\|3445689_3446851_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	1.4e-80	54.6
WP_016182049.1\|3447678_3447816_-	hypothetical protein	NA	NA	NA	NA
WP_002287105.1\|3447978_3448953_+	choloylglycine hydrolase family protein	M1HVK5	Paramecium_bursaria_Chlorella_virus	5.4e-25	31.8
WP_137440021.1\|3449102_3450265_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	1.4e-80	54.6
WP_080116578.1\|3451191_3451515_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	U5P429	Shigella_phage	2.0e-16	47.6
3454813:3454829	attR	NA	NA	NA	NA

DBSCAN-SWA_8

3454931 : 3487167

Bacillus_phage(22.22%)

transposase,integrase

attL 3479672:3479687|attR 3492480:3492495

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016178709.1\|3454931_3456173_+\|transposase	IS110 family transposase	Q9JMN8	Wolbachia_phage	2.3e-28	25.8
WP_002297866.1\|3458039_3459359_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_002285815.1\|3459355_3460009_-	response regulator transcription factor	W8CYM9	Bacillus_phage	4.0e-24	33.2
WP_016252571.1\|3460297_3461572_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	2.0e-56	36.4
WP_002326114.1\|3461785_3462817_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.0e-26	34.6
WP_016180798.1\|3462797_3463655_-	hypothetical protein	NA	NA	NA	NA
WP_137440023.1\|3463651_3464458_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_002326111.1\|3464463_3465288_-	hypothetical protein	NA	NA	NA	NA
WP_016180797.1\|3465277_3466369_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_002326109.1\|3466546_3467332_+	histidinol phosphate phosphatase HisJ family protein	NA	NA	NA	NA
WP_002326108.1\|3467363_3467747_+	hypothetical protein	NA	NA	NA	NA
WP_081638479.1\|3467822_3467954_+	hypothetical protein	NA	NA	NA	NA
WP_016180796.1\|3467922_3468147_+	hypothetical protein	NA	NA	NA	NA
WP_071879971.1\|3468121_3468361_+	hypothetical protein	NA	NA	NA	NA
WP_016180795.1\|3468453_3469227_-	glycyl-radical enzyme activating protein	NA	NA	NA	NA
WP_016180794.1\|3469942_3470668_-	hypothetical protein	NA	NA	NA	NA
WP_028020813.1\|3470821_3471151_-	hypothetical protein	NA	NA	NA	NA
WP_070503603.1\|3471287_3472694_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_002404111.1\|3472726_3472942_-	helix-turn-helix transcriptional regulator	A0A139ZPI6	Marinitoga_camini_virus	1.4e-05	40.0
WP_016180789.1\|3474849_3475188_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_016180788.1\|3475369_3476617_-\|transposase	IS256 family transposase	A0A0K2CZ57	Paenibacillus_phage	1.6e-29	24.9
WP_016180787.1\|3476746_3478123_-	ABC transporter permease	NA	NA	NA	NA
WP_002298083.1\|3478122_3478779_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-22	32.1
WP_016180786.1\|3478788_3480066_-	ABC transporter permease	NA	NA	NA	NA
3479672:3479687	attL	NA	NA	NA	NA
WP_167494441.1\|3480084_3480504_-	4Fe-4S binding protein	NA	NA	NA	NA
WP_167494442.1\|3480496_3480601_-	4Fe-4S binding protein	NA	NA	NA	NA
WP_002330915.1\|3480609_3480891_-	hypothetical protein	NA	NA	NA	NA
WP_016180785.1\|3480915_3482067_-	TlpA family protein disulfide reductase	NA	NA	NA	NA
WP_028020890.1\|3482190_3482478_+	hypothetical protein	NA	NA	NA	NA
WP_071879969.1\|3482478_3482727_+	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_016178403.1\|3484317_3485565_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	3.4e-32	40.3
WP_137440024.1\|3486018_3487167_-\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	5.2e-35	29.3
3492480:3492495	attR	NA	NA	NA	NA

DBSCAN-SWA_9

3519393 : 3531886

Streptococcus_phage(88.89%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002297293.1\|3519393_3520581_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	4.6e-26	28.7
WP_137440027.1\|3520791_3522915_-	FUSC family protein	A0A1S5SF30	Streptococcus_phage	2.1e-175	62.3
WP_137440028.1\|3522919_3525367_-	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.0
WP_070504249.1\|3525353_3525743_-	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	1.5e-42	68.3
WP_070504252.1\|3525800_3526916_-\|protease	ATP-dependent Clp protease ATP-binding subunit	NA	NA	NA	NA
WP_070504254.1\|3526918_3527713_-	hypothetical protein	NA	NA	NA	NA
WP_070504257.1\|3527745_3528249_-	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	2.0e-52	61.0
WP_002298822.1\|3528260_3528482_-	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.5e-28	87.7
WP_070504260.1\|3528486_3528606_-	DUF3789 domain-containing protein	NA	NA	NA	NA
WP_070504264.1\|3528620_3529805_-	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	1.2e-140	61.4
WP_070504267.1\|3530061_3530352_-	hypothetical protein	NA	NA	NA	NA
WP_070504270.1\|3530341_3531484_-	DNA (cytosine-5-)-methyltransferase	A0A1S5SEK0	Streptococcus_phage	6.2e-129	62.6
WP_118368251.1\|3531529_3531886_-	cell division protein FtsK	A0A1S5SFB5	Streptococcus_phage	1.3e-45	83.8

DBSCAN-SWA_10

4026894 : 4035447

Streptococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_137440158.1\|4026894_4028112_-	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	5.7e-32	29.8
WP_137440159.1\|4028260_4029115_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	6.7e-88	60.5
WP_034876619.1\|4029312_4029660_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	2.2e-13	34.2
WP_016180911.1\|4029659_4030472_-	stage 0 sporulation family protein	NA	NA	NA	NA
WP_137440160.1\|4030498_4031437_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	1.7e-36	35.6
WP_010740793.1\|4031438_4031768_-	hypothetical protein	NA	NA	NA	NA
WP_016180913.1\|4031780_4032425_-	dTMP kinase	M1PSC7	Streptococcus_phage	4.2e-58	51.7
WP_016180914.1\|4032483_4033080_-	recombination protein RecR	NA	NA	NA	NA
WP_016180915.1\|4033289_4033604_-	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_137440161.1\|4033698_4035447_-	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	1.6e-51	38.1

DBSCAN-SWA_11

4152645 : 4215731

Bacillus_phage(45.45%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071879978.1\|4152645_4153950_-\|transposase	transposase	NA	NA	NA	NA
WP_016181025.1\|4154122_4154887_-	protein-tyrosine-phosphatase	NA	NA	NA	NA
WP_137440209.1\|4154894_4155644_-	CpsD/CapB family tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	1.6e-24	35.4
WP_016181027.1\|4155681_4156467_-	hypothetical protein	NA	NA	NA	NA
WP_016181028.1\|4156481_4157327_-	hypothetical protein	NA	NA	NA	NA
WP_049219316.1\|4157375_4158026_-	class D sortase	NA	NA	NA	NA
WP_016181030.1\|4158051_4158645_-	hypothetical protein	NA	NA	NA	NA
WP_016181031.1\|4159047_4160001_-	transcriptional regulator	NA	NA	NA	NA
WP_099434174.1\|4160515_4161678_-\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	1.4e-80	54.6
WP_016181033.1\|4162484_4163315_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_016181034.1\|4163324_4165115_-	hypothetical protein	NA	NA	NA	NA
WP_137440210.1\|4165138_4166653_-	oligosaccharide flippase family protein	NA	NA	NA	NA
WP_016181036.1\|4166645_4167773_-	polysaccharide pyruvyl transferase family protein	NA	NA	NA	NA
WP_137440211.1\|4167732_4168992_-	hypothetical protein	NA	NA	NA	NA
WP_016181038.1\|4168988_4170077_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_016181039.1\|4170111_4171293_-	DUF1972 domain-containing protein	NA	NA	NA	NA
WP_016181040.1\|4171305_4172022_-	sugar transferase	NA	NA	NA	NA
WP_016181041.1\|4172045_4172813_-	protein-tyrosine-phosphatase	NA	NA	NA	NA
WP_016181042.1\|4172831_4173536_-	CpsD/CapB family tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	1.6e-26	40.5
WP_016181043.1\|4173545_4174334_-	hypothetical protein	NA	NA	NA	NA
WP_137440489.1\|4175037_4175235_-	hypothetical protein	NA	NA	NA	NA
WP_137440180.1\|4175206_4176526_-\|transposase	transposase	NA	NA	NA	NA
WP_137440213.1\|4178722_4179511_-	TPM domain-containing protein	NA	NA	NA	NA
WP_016181045.1\|4179809_4180373_+	peroxiredoxin	NA	NA	NA	NA
WP_137440214.1\|4180382_4181924_+	alkyl hydroperoxide reductase subunit F	G3MA85	Bacillus_virus	5.7e-37	29.4
WP_016181047.1\|4182445_4182871_-	Spx/MgsR family RNA polymerase-binding regulatory protein	NA	NA	NA	NA
WP_016252566.1\|4183763_4185080_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	2.7e-51	35.3
WP_102872284.1\|4185186_4186380_-	peptidase M23	A0A217EQJ4	Bacillus_phage	2.4e-19	55.9
WP_016181049.1\|4186573_4187353_-	hypothetical protein	NA	NA	NA	NA
WP_137440215.1\|4187879_4189400_+	hypothetical protein	NA	NA	NA	NA
WP_137440216.1\|4189560_4191285_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.0e-50	28.6
WP_137440217.1\|4191281_4193039_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.1e-50	30.9
WP_137440218.1\|4193311_4193989_-	DUF3862 domain-containing protein	NA	NA	NA	NA
WP_082158217.1\|4194347_4194629_+	hypothetical protein	NA	NA	NA	NA
WP_137440219.1\|4195866_4197054_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	2.3e-25	28.5
WP_167494460.1\|4200775_4201921_-	beta-hexosaminidase	NA	NA	NA	NA
WP_016181057.1\|4202213_4202921_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016181058.1\|4203088_4203700_-	hypothetical protein	NA	NA	NA	NA
WP_049221154.1\|4203803_4204745_-	rhodanese-related sulfurtransferase	NA	NA	NA	NA
WP_016181060.1\|4205039_4205291_-	hypothetical protein	NA	NA	NA	NA
WP_016181061.1\|4205367_4205970_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_016181062.1\|4206261_4206507_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_016181064.1\|4206699_4207050_-	iron-sulfur cluster biosynthesis family protein	NA	NA	NA	NA
WP_102872273.1\|4207073_4207925_-	glycosyltransferase family 8 protein	NA	NA	NA	NA
WP_167494461.1\|4207917_4208760_-	glycosyltransferase family 8 protein	A0ZYL4	Archaeal_BJ1_virus	2.7e-17	25.5
WP_137440222.1\|4209410_4209980_+	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
WP_034876598.1\|4209991_4210180_+	DUF2273 domain-containing protein	NA	NA	NA	NA
WP_137440223.1\|4210192_4210741_+	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_137440224.1\|4212660_4214241_-	bifunctional aspartate transaminase/aspartate 4-decarboxylase	NA	NA	NA	NA
WP_002297293.1\|4214543_4215731_+\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	4.6e-26	28.7

DBSCAN-SWA_12

4250538 : 4268400

Streptococcus_phage(94.12%)

integrase

attL 4249344:4249359|attR 4269755:4269770

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4249344:4249359	attL	NA	NA	NA	NA
WP_000398284.1\|4250538_4251744_+	XRE family transcriptional regulator	A0A1S5SEX3	Streptococcus_phage	2.8e-233	100.0
WP_001009056.1\|4251786_4252008_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.3e-31	100.0
WP_000342539.1\|4252124_4252622_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.7e-91	100.0
WP_000506270.1\|4252596_4253103_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	8.6e-91	100.0
WP_000331160.1\|4253086_4255534_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	100.0
WP_000804748.1\|4255536_4257714_+	membrane protein	A0A1S5SF30	Streptococcus_phage	0.0e+00	100.0
WP_137440236.1\|4257710_4258655_+	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	6.1e-175	100.0
WP_137440237.1\|4259368_4261198_+	group II intron reverse transcriptase/maturase	A0A0U4J920	Pseudomonas_phage	1.5e-39	29.8
WP_137440491.1\|4261197_4261359_+	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	3.5e-06	100.0
WP_001224318.1\|4261355_4262288_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	3.1e-171	99.4
WP_001814923.1\|4262532_4262649_+	tetracycline resistance determinant leader peptide	NA	NA	NA	NA
WP_000691736.1\|4262664_4264584_+	tetracycline resistance ribosomal protection protein Tet(M)	A0A1S5SF82	Streptococcus_phage	0.0e+00	99.5
WP_000336323.1\|4264702_4264870_+	conjugal transfer protein	D0R0F6	Streptococcus_phage	1.6e-14	68.0
WP_137440238.1\|4264929_4265283_-	helix-turn-helix transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	3.0e-58	99.1
WP_000804885.1\|4265787_4266210_+	sigma-70 family RNA polymerase sigma factor	A0A1S5SEW0	Streptococcus_phage	2.5e-72	100.0
WP_000857133.1\|4266206_4266437_+	helix-turn-helix domain-containing protein	A0A1S5SEX1	Streptococcus_phage	2.7e-36	100.0
WP_000814511.1\|4266897_4267101_+	excisionase	A0A1S5SF07	Streptococcus_phage	4.0e-31	100.0
WP_001291561.1\|4267182_4268400_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW7	Streptococcus_phage	3.7e-233	100.0
4269755:4269770	attR	NA	NA	NA	NA

DBSCAN-SWA_13

4677943 : 4695395

Streptococcus_phage(91.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_137440397.1\|4677943_4678960_+	DUF87 domain-containing protein	A0A1S5SFB5	Streptococcus_phage	1.1e-105	59.3
WP_083284937.1\|4679553_4681428_+	group II intron reverse transcriptase/maturase	NA	NA	NA	NA
WP_137440500.1\|4681553_4681910_+	cell division protein FtsK	A0A1S5SFB5	Streptococcus_phage	2.2e-45	78.6
WP_137440398.1\|4681954_4683097_+	DNA (cytosine-5-)-methyltransferase	A0A1S5SEK0	Streptococcus_phage	2.3e-128	66.3
WP_137440399.1\|4683086_4683377_+	hypothetical protein	NA	NA	NA	NA
WP_137440400.1\|4683632_4684817_+	helix-turn-helix domain-containing protein	A0A1S5SEX3	Streptococcus_phage	6.6e-142	61.9
WP_164709457.1\|4684831_4684927_+	DUF3789 domain-containing protein	NA	NA	NA	NA
WP_002298822.1\|4684955_4685177_+	hypothetical protein	A0A1S5SEY0	Streptococcus_phage	4.5e-28	87.7
WP_137440401.1\|4685188_4685692_+	antirestriction protein ArdA	A0A1S5SF25	Streptococcus_phage	1.3e-51	59.6
WP_137440402.1\|4685769_4688454_+	hypothetical protein	A0A1B1IUG5	uncultured_Mediterranean_phage	1.6e-10	44.3
WP_002297349.1\|4688515_4688905_+	conjugal transfer protein	A0A1S5SEX7	Streptococcus_phage	3.9e-43	68.3
WP_122646618.1\|4688891_4691339_+	ATP-binding protein	A0A1S5SF64	Streptococcus_phage	0.0e+00	76.4
WP_137440403.1\|4691343_4693464_+	FUSC family protein	A0A1S5SF30	Streptococcus_phage	2.3e-182	59.2
WP_137440404.1\|4693460_4694465_+	peptidase P60	A0A1S5SEZ8	Streptococcus_phage	1.2e-120	64.8
WP_137440405.1\|4694483_4695395_+	conjugal transfer protein	A0A1S5SF22	Streptococcus_phage	3.0e-62	43.7

Anti-CRISPR protein detection

Acr_ID: NZ_CP034169.1|WP_137439994.1|3332439_3332973_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_CP034169.1|WP_167494439.1|3333157_3333322_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP034169.1|WP_137439994.1|3332439_3332973_-|hypothetical-protein

3332439_3332973_-

177 aa aa

3250503-3334562

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP034169_1	Unclear	1.16\|138449\|37\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	138449-138485	37	3326710-3326746	0

1. spacer 1.16|138449|37|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034169 position: 3326710-3326746, mismatch: 0

tcttctgaataccgttgctagtcatagctgttcccac	CRISPR spacer
tcttctgaataccgttgctagtcatagctgttcccac	Protospacer
*************************************

NZ_CP034169.1|WP_167494439.1|3333157_3333322_-|hypothetical-protein

3333157_3333322_-

54 aa aa

3250503-3334562

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP034169_1	Unclear	1.16\|138449\|37\|NZ_CP034169\|PILER-CR,CRISPRCasFinder,CRT	138449-138485	37	3326710-3326746	0

1. spacer 1.16|138449|37|NZ_CP034169|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034169 position: 3326710-3326746, mismatch: 0

tcttctgaataccgttgctagtcatagctgttcccac	CRISPR spacer
tcttctgaataccgttgctagtcatagctgttcccac	Protospacer
*************************************

2. NZ_CP034168

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP034168_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP034168_1

54851-54980

Orphan

Consensus_repeat	Method
TTGGCTGGGTATGATTTTCATACCC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP034168_1

>merge|NZ_CP034168|1|54851-54980|CRISPRCasFinder
TAATACCTGTTTGATTTTCATACCCTCTGATTTATCAACGTTTTGGCTGGGTATGATTTTCATACCCTTTTGGGCATCAAGGGATTGAGGCTCATTTGAATTTTGTTGGCTGGGTATGATGTTCATACCC

>NZ_CP034168|1|1|54851-54980|CRISPRCasFinder
TAATACCTGTTTGATTTTCATACCC	TCTGATTTATCAACGTT
TTGGCTGGGTATGATTTTCATACCC	TTTTGGGCATCAAGGGATTGAGGCTCATTTGAATTTTG
TTGGCTGGGTATGATGTTCATACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP034168.1\|WP_070504141.1\|50991_51189_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_070503595.1\|44531_47759_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|375630
NZ_CP034168.1\|WP_137438811.1\|62866_63700_+\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	unknown	unknown	gnl\|CDD\|377079
NZ_CP034168.1\|WP_137438800.1\|62063_62864_+\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|377077
NZ_CP034168.1\|WP_137438798.1\|60833_61475_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP034168.1\|WP_070503201.1\|56898_57222_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_070503199.1\|55886_56888_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379293
NZ_CP034168.1\|WP_070503593.1\|43499_44459_-\|class-A-sortase	unknown	unknown	gnl\|CDD\|320680
NZ_CP034168.1\|WP_137438799.1\|61568_62051_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|377139
NZ_CP034168.1\|WP_070503203.1\|57465_57681_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_137438795.1\|51206_51413_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_070503791.1\|47934_48660_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_118368260.1\|50055_50430_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP034168.1\|WP_070504146.1\|52104_52446_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_070503194.1\|53569_54295_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_118368257.1\|58138_59494_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP034168.1\|WP_070621550.1\|50396_50657_-\|toxin-antitoxin-system,-antitoxin-component,-AbrB-family-protein	unknown	unknown	gnl\|CDD\|225215
NZ_CP034168.1\|WP_137438797.1\|59506_60022_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_CP034168.1\|WP_070503788.1\|48683_50036_-\|C39-family-peptidase	unknown	unknown	gnl\|CDD\|379241
NZ_CP034168.1\|WP_137438801.1\|63709_64639_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380413

Protein	Function_ID	Function_description	E-value
NZ_CP034168.1\|WP_070503595.1\|44531_47759_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|375630	pfam18202, TQ, T-Q ester bond containing domain. This domain is found in gram positive bacterial surface proteins. It contains a very unusual isopeptide bond between a conserved N-terminal threonine residue on the first beta strand of the Ig-like fold and and a glutamine residue in the final strand of the domain.	6.39419e-23
NZ_CP034168.1\|WP_137438800.1\|62063_62864_+\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|377077	pfam03609, EII-Sor, PTS system sorbose-specific iic component.	1.359e-57
NZ_CP034168.1\|WP_137438811.1\|62866_63700_+\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	gnl\|CDD\|377079	pfam03613, EIID-AGA, PTS system mannose/fructose/sorbose family IID component.	8.33956e-86
NZ_CP034168.1\|WP_137438801.1\|63709_64639_+\|hypothetical-protein	gnl\|CDD\|380413	cd07010, cupin_PMI_type_I_N_bac, Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	1.11193e-30
NZ_CP034168.1\|WP_137438798.1\|60833_61475_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.99335e-50
NZ_CP034168.1\|WP_070503199.1\|55886_56888_+\|AAA-family-ATPase	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.16009e-29
NZ_CP034168.1\|WP_070503593.1\|43499_44459_-\|class-A-sortase	gnl\|CDD\|320680	cd06165, Sortase_A, Sortase domain found in class A sortases. Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate.	4.84973e-45
NZ_CP034168.1\|WP_137438799.1\|61568_62051_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|377139	pfam03830, PTSIIB_sorb, PTS system sorbose subfamily IIB component.	1.22801e-36
NZ_CP034168.1\|WP_118368260.1\|50055_50430_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.52546e-20
NZ_CP034168.1\|WP_070621550.1\|50396_50657_-\|toxin-antitoxin-system,-antitoxin-component,-AbrB-family-protein	gnl\|CDD\|225215	COG2336, MazE, Growth regulator [Signal transduction mechanisms].	2.84785e-08
NZ_CP034168.1\|WP_137438797.1\|59506_60022_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.90786e-22
NZ_CP034168.1\|WP_070503788.1\|48683_50036_-\|C39-family-peptidase	gnl\|CDD\|379241	pfam13529, Peptidase_C39_2, Peptidase_C39 like family.	1.15663e-15

>NZ_CP034168.1|WP_070503194.1|53569_54295_-|hypothetical-protein
MLARTVHAFLEDKKISGAVRKLGEKEYYFRIDTQKLSAPLKPGMLAFSSDGQLVYILEIIDDRTPEEEAAYTGVLTKIVADNPAIKSGGKGIERKILSAVEKVVYTGIVVELVDKKFRRTEKEMRFRSTERIDGKISKGDIVPIVLHTKNGRKERHYVLVQRIIKNASQKQRVMNTRRTPTKWFYKKTDKGYKKTRYAQDVIENGESKNKPTNNQSEKGIKEADKELNSTKRNFVIRQRKD
>NZ_CP034168.1|WP_070504146.1|52104_52446_-|hypothetical-protein
MGRRIGIEDIGYYADKITVYEKILVRRDSTGSPIYKTGVKEYRVKGLFAQKIQLYFVDGKAKEVLCDPVPLKQLYKRIRHVYDFNKVLIARRNTPNQPLLITGKGMSKFLKLG
>NZ_CP034168.1|WP_137438795.1|51206_51413_-|hypothetical-protein
MMNLFLIETKELKDVKKGWKTIAKTRIAAANVNEALKIVERRFTKYQYIHEVISEKESTLDSTVRRYF
>NZ_CP034168.1|WP_070504141.1|50991_51189_-|hypothetical-protein
MLESRGHHMTTKKKRKKFALRDETIEKLNYLIEQKQVRSTTKVYPCDVLEEVINNAYEIAKVFKS
>NZ_CP034168.1|WP_070621550.1|50396_50657_-|toxin-antitoxin-system,-antitoxin-component,-AbrB-family-protein
MLIKDTELKTWGNSKALRIGKDELAALGLSDKQLAITLIVENGKITIVPKTKYPQTLDELFAGYDGAALTPDDRYEWDEPVGREII
>NZ_CP034168.1|WP_118368260.1|50055_50430_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MGRASREGNYLVVEKKIFSDLQQGDILFLDFDPTKGHEQRGYRPCIVLTKSIRFLNYMFGVAPITSNSRSFPLHIPLPETMEVKGNVLLEHHRMVDLETRTFKFVETAPPEFIEECVAKLKLLY
>NZ_CP034168.1|WP_070503788.1|48683_50036_-|C39-family-peptidase
MKKKCWKLLVIGLLTIPLGIGSVVQAEDSLEQSSQTVQTETSTSETSQVQVNKIEFSQTEISQEESNQDTESQPESPDLTNLNPAKRATPDQENMAPDPETSEIAEEDARSASLPVEVYAANSLKPIYRVYNPNSGEHLHTLNGGEKDNLMSLGWVYEGISMQIDGSGSNLYRAYNPNSGEHFYTKDSKEIDKIKRAGWRYEGVAWKVPNSGKNVYRLFNPNARDAGSHHYTLLESEKNDLVKRGWRYEGVSWAVTGGSVTVKSTNVINSVPYISQYTPVKAPWGCASASLAMLLGSKNIRPNLRTMQDRLPMYPSNPNGQKGNVYTGSGFGWVIKPNALAAYGRTYGGNTVDISGSNTVQIINRVLNGQPVLYYGYSSYQNNTDKNRNHCKVIAGYNGGKFLVYDPLYYSSNAGAGSGGKNMLYDRGARAWVTMGQYNAEKDGRAITIQ
>NZ_CP034168.1|WP_070503791.1|47934_48660_-|hypothetical-protein
MKMKFLGKVVVGLGVLLGVGGVALASGTDAEAAQLYRAYNPNTGEHLYTANASEIPFVVKAGWRNEGYAWEAPSKGAPVYRMFNPNNGGDHHYTLNASERDHLKKVGWRYEGISWQSGGSTPVYRLYNPNAKSGTHHFTTLASEKNHLVKVGWRYEGVAFYSGKDQPTTPPKPTEPSKPTEPTIVSGWVGNTGKVFATYEEANQYGRAECLKEGSQYSRWVNITIVYSDGSKKYSVSLYEE
>NZ_CP034168.1|WP_070503595.1|44531_47759_-|LPXTG-cell-wall-anchor-domain-containing-protein
MNKLKKIAASLMLLFTLSGQIAPTAQVFAEEASKTEVSSSRTVEKEERENKETTESSQAKETTESTTTDESINAEKPEIGESQNSNDSPKVEEETDVNEQLAKVLKDYGYYMTTDGQFLSSTNESVRDNWSEFLSKVQDLRSESQMAKRALSIVPRAGLSIFVDQNYSIPTVSWDYSNGIHEIGFYAKRDAAGGLLWCVAPGNPLNFGENSGFTTEELNQQNLVIASLIAYWGYETQPSVENAFYTEHHIQNMGTGVTTSNIQDPSGRVSQAGFDAWIKETNRKINSYLTKPSFNNNSYTMKKGETLRIDDTNSSLWAYKVATNSANLNVSTDGNTLVLKATGDVKDGSIQLEYNVPESYKGATLVYRHPYSQELLHCSISDPNIVRLNIKIQKEGKLLLKKVDDTGKAIAGAEFNLIANGKTTKATTNSSGELSTPDYNVGTVVQYEETKAPSGHYIDPATSKGSVTLKEGTNTIKVTNPRFANLTLVKKNDKGKNLEGVTFKLNYGNKDYTVKTDKDGQIKVTNTLKNNDKVSYEEVATLKGHYIDPETSKGEITVKSGENTLNINNPTLNFGMTSQARNTDREQFINPAKDQELVDEVMIEAHQAPANAKLRLTTDFVEFGTGEQLGEASLKQSTEFEAEQARFVKAVALNFDATNLHGKKGVFTNVLEYFNPSTQEWEEVARHDDLNNEDEAIQIVEPKIHTEFFFYDQNGNESKLSDPLAKVKGYDRVHYENLISGKEYKFDLALMNKDGKTPFTDPDGKEVTGTLTVVAGKDGVVTTKVDAKEYYENLAKEEAEKEDSKGSDDTKEESDIKPLSDEESQEEATEGEEEPQEVQTEFSEVKSVELLTGYVDVPFEANLSVANGKVVVAYEQLSTNETPIAEHKDPDSEEQTGKIRNPEISTRAMVNGEKQVTTDGKIKFDDTVEYKDLTPGVEYEMEMTIMVKDENAPLKLQDKEVTGKAKFTPEKENGETTVTVDFDAKELFSKYGDSVDLVAFEKTITNGEVIAVHEDINDSGQTVKINKPVVPAKTTKTTLPQTAGMLTNPYVLIAALALVAGAIFLLKNRKEGQEK
>NZ_CP034168.1|WP_070503593.1|43499_44459_-|class-A-sortase
MRKLIKALPLIYFICGLCFAGACFVGYRQLLSSDDNAKQMTHQIQSKEKSQQQLKEKKKLANYDPNQIKPVTPREYAAAQLKYEDIVNHYGIGSIFIPSSNIRSKILAGLSNQNLMVAVGTYYSDQELGKGNYVLLAHNLVEGGGALGNLPNTKLDHIIYATDFTNIYEYKAIKNETVNQANGQLLEKPSDNEPAIITLFRCEGAINTPNRALVQGEFVRSYPANEAANDVKVGLGLGVMTNNSKHEGATEQATPQQSTQRKYSTNTSIKQFKQDKPTYSFLEKIAINCFSIVSEYPLYIGSGFLLILLLLQRVTKKYS
>NZ_CP034168.1|WP_070503199.1|55886_56888_+|AAA-family-ATPase
MNEELIVTGNRCRVLINANQKGGVGKTTSTTEEAAVATLPVPQFNKKVLIIDWDIQANATSLMGKTFDVSFPTSIFQAIKDAADGIKDALRKATVKLTDNLHMIAGGRDMADYGDLLEDLYPKEKDENGELIDPLFKKKRTFHFSKLLEEIKEDYDYIWIDVGPSTDIKVDNAMVCADYFIITQETKTYSFEGSLDIINEYLQTLIDDFGDDFKGEVLGLLPFLLQPKRELHESIIENTKEAFGENFTFNAIVNNQKRLEEYPEYGISVVDYHDRKVFAMFADIFTEIEERIALFERDGDIPDEYRYVPKYLNGNKLTKLSRELDLSQYELNK
>NZ_CP034168.1|WP_070503201.1|56898_57222_+|hypothetical-protein
MALTDRKKKDRPKVDRMVETPRIANEPTETSVKEISETVAKKEWTAKDRKTIKVDPDIKSLIEIFSDFDGTKEYNTIRQMAEFYLEKNYDERAQRIITNIQKNKFIK
>NZ_CP034168.1|WP_070503203.1|57465_57681_-|hypothetical-protein
MSEIRLKKIVDDKKSNLEKLSSETLVPYPTLKQWYETSHFDSSNVGVQELTNVAAALNVDITELIEFPKSK
>NZ_CP034168.1|WP_118368257.1|58138_59494_-|hypothetical-protein
MSKIKPNIRYLIIGWMITIFLVCLLFNLNIHLTGFKDDGDLFYKPLINKYNGNYLDFLVNRYNTWSSRSIIEIFTLLGVTQPIIWRCLNTLMMWIAAILPAYIIQKKDKVNIYGLILSAALFFTFPLTFFSETGWIATTTNYLWVFSMGLLSIYPLARYTRKEKKHLWLSIVGIIATLYATNQEQMALLILAFTIILGIFNWYKKRSIKPLLPTFIIGTLNLIYVLTARGNEIRYNQELTNWFPDFEKLSIPKKIELGYSSTLRHLFFDKQSTILLFLFLLFVFTLSSQIYRKKFSFIGIFGLLPLPISLLFSFNEYLQNGRVLEVLNNFNQYGTTINLLDPKTWIPDILLTILLMSILVAIIYLLDYQVTSYVPLLFICAAIVSRLIMGFSPTIWASATRTYLFTFGLFNLTFLYLFTNCQTFKFSKALVWFSCILVGCWSIIETIGSLR
>NZ_CP034168.1|WP_137438797.1|59506_60022_-|recombinase-family-protein
MSFKYKSYMSGKNTNRPALLEMLDYIREGDIVVVTELERLGRNSKELTDLMYQIQSKRATLEILNLPATQGIEDENLRNLINNLIIEIYKYQAESERIRILERQKQGIAIAKREGKYKGRKPLFNEADARLQHAFKLYKDGMSDKDVERNTGINRETFRRYRKKIGIERLK
>NZ_CP034168.1|WP_137438798.1|60833_61475_+|histidine-phosphatase-family-protein
MTEFYLIRHGKTEFNVEKRFQGGAVDSKLLSSALEDSKKLGKELRYVPFDLLLTSEQQRAIHTGNIIADYNINQKTMNRETNKNLNEINFGIWEGVLEDKIPHSDQLLLFRNTPEKFDARIIDGEHYYEVYARMKPIFDEITLKYPHGKILIVSHGMALLALVNGLLKTPYSQFRKLPNLDNNSVSILLKDQKEWILKKWNNIFLFDSTRNIH
>NZ_CP034168.1|WP_137438799.1|61568_62051_+|PTS-sugar-transporter-subunit-IIB
MIVHYRVDERVIHGQTTTKITKEVHVDGIIIVDDKIAGDKFMMQLYKQILPSHIKVFSFSIEKALKKLSEAEKSNKNYVVIMKTPLTARKMVEGGYNFKNTLFIGPQSVREGSTFIMQMVGLMPNEMEALDYLESNKTTVIMNPTFTTPNLTWSEAKGKI
>NZ_CP034168.1|WP_137438800.1|62063_62864_+|PTS-sugar-transporter-subunit-IIC
MYILQISAISILYYLSNVYSSFGGFVISKYTLCRPLIGGFLCGLILGDVQKGIEIGVAMQLAFMGSFAVGGAMTMDIGAVSFPVIAVAIISDLDVGAALAIATPISILAANLIQIVRGMNTIFARIMRKGVEETNYKKILTGHFILPQLFLLVMSFIVSFVFIYFGASAVESFIDLLPERILHALSQLAKVLPAVGMALLLKYNITNNFMFVFFVFGFMLFAYAEMSFIPIAIIAMVIAYFYYRTDAIKKEVAEVVPDFDEEDEIL
>NZ_CP034168.1|WP_137438811.1|62866_63700_+|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID
MLTNLSEKREALTRKELIKLFWQYQLHYAYSINFENWHGDGYAFCMAPLFKKYYDKDGQKDGMIRQLDFHNNEQTTASVVWGVMVGMEEQKALGENVDDEMIRTTKSALMGPVAGIGDSLIQATIVPLLTTIAITLTGDSNSPLGSILYMITTPIILWGYAYFLYNKGYTFGRNAVMMLSGSMLDKIRSAIQVFGIIVIGALSASYVKLETVLKFSAGKGTEPIVLQDILNNIFPNLLSLLLVVGCYFLVSKKNVSITKLIVLLMVGVVALSLLGLI
>NZ_CP034168.1|WP_137438801.1|63709_64639_+|hypothetical-protein
MKNIYHVRPLYKSFIWGGQKLIDFFKIETTLDNIGTVYHVISLPGELDNIIEETDQPLSEFYRENKELFGISTPHFPIRMTTTANEGFQSYQLHPDDDYAFKHENQQGKVSGAVSLEESDHVKTRLFGNKAKDKDEFKKMILEKDWDNLFTTLDVKDGDFVHTPAGVIHGGYGDGQVTSTFGTNGDITYRFYDLDRNDPNRPLHLQEVFDCATVPEVPFESKHVESEKRENLEVYDYYDVAGEYVAKRFKIYGNSVYSYPDFMFLACVGGSGTISGENISLGETLFIPKDFGDLKFSGEMDIIMVSYKE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP034168_1	1.2\|54918\|38\|NZ_CP034168\|CRISPRCasFinder	54918-54955	38	NZ_CP034168	Enterococcus avium strain 352 plasmid unnamed, complete sequence	54918-54955	0	1.0

1. spacer 1.2|54918|38|NZ_CP034168|CRISPRCasFinder matches to NZ_CP034168 (Enterococcus avium strain 352 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

ttttgggcatcaagggattgaggctcatttgaattttg	CRISPR spacer
ttttgggcatcaagggattgaggctcatttgaattttg	Protospacer
**************************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2337 : 20036

Streptococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_137438785.1\|2337_3807_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_137438786.1\|3974_5987_-	penicillin-binding transpeptidase domain-containing protein	NA	NA	NA	NA
WP_137438787.1\|6046_7804_-	BlaR1 family beta-lactam sensor/signal transducer	NA	NA	NA	NA
WP_137438788.1\|7804_8179_-	BlaI/MecI/CopY family transcriptional regulator	A0A2R2ZGM0	Clostridioides_phage	9.7e-07	32.3
WP_060789052.1\|8329_8767_-	hypothetical protein	NA	NA	NA	NA
WP_137438789.1\|9035_10088_-	BMP family ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_137438790.1\|10650_11331_+\|transposase	IS6 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-114	88.8
WP_167494419.1\|11658_12336_+\|transposase	IS6 family transposase	A0A1X9I6C6	Streptococcus_phage	4.8e-113	98.1
WP_048718569.1\|12319_12517_-	hypothetical protein	NA	NA	NA	NA
WP_137438791.1\|12488_13808_-\|transposase	transposase	NA	NA	NA	NA
WP_137438792.1\|14009_15470_-	sigma 54-interacting transcriptional regulator	NA	NA	NA	NA
WP_048722676.1\|16515_17274_-	ATP-binding protein	A0A059NT77	Lactococcus_phage	3.6e-85	65.1
WP_112132922.1\|17284_18442_-\|transposase	IS21 family transposase	A0A059NT83	Lactococcus_phage	1.1e-120	58.4
WP_070503607.1\|18581_20036_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	2.2e-06	22.8

DBSCAN-SWA_2

71923 : 80361

Streptococcus_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001015311.1\|71923_72604_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_071621498.1\|73514_74369_+	ParA family protein	A0A1X9I765	Streptococcus_phage	2.4e-154	99.6
WP_002295735.1\|74467_74683_+	peptide-binding protein	A0A1X9I6D5	Streptococcus_phage	1.4e-31	98.6
WP_000301765.1\|74699_74972_+	antitoxin	A0A1X9I6E5	Streptococcus_phage	5.0e-05	100.0
WP_071621496.1\|74973_75837_+	toxin zeta	NA	NA	NA	NA
WP_001015311.1\|76280_76961_-\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_001028144.1\|77883_79323_-	aminoglycoside O-phosphotransferase APH(2'')-Ia	A0A1X9I6C2	Streptococcus_phage	3.8e-285	100.0
WP_001015311.1\|79680_80361_-\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP034169

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

2. NZ_CP034168

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection