CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP039432	Rhodococcus sp. SGAir0479 chromosome, complete genome	2 crisprs	cas3,WYL,csa3,DinG,cas4,DEDDh	0	0	3	0
NZ_CP039433	Rhodococcus sp. SGAir0479 plasmid unnamed	0 crisprs	csa3	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP039432_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP039432_1

2447006-2447145

Orphan

Consensus_repeat	Method
AGAGCAAGTGACTCTTAATCACTGGGTTCGGGGTTCGAGTCCCTG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP039432_1

>merge|NZ_CP039432|1|2447006-2447145|CRISPRCasFinder
AGAGCAAGTGACTCTTAATCACTGGGTTCGGGGTTCGAGTCCCTGGCGGCGCACGCTAGATTGCTAGCACGGCTGGCGCCTATAGCTCAGTTGGTAGAGCAAGTGACTCTTAATCACTGGGTCCGGGGTTCGAGTCCCTG

>NZ_CP039432|1|1|2447006-2447145|CRISPRCasFinder
AGAGCAAGTGACTCTTAATCACTGGGTTCGGGGTTCGAGTCCCTG	GCGGCGCACGCTAGATTGCTAGCACGGCTGGCGCCTATAGCTCAGTTGGT
AGAGCAAGTGACTCTTAATCACTGGGTCCGGGGTTCGAGTCCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP039432.1\|WP_137799066.1\|2447327_2447549_-\|DUF3618-domain-containing-protein	unknown	unknown	gnl\|CDD\|378834
NZ_CP039432.1\|WP_137799067.1\|2447691_2448162_+\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP039432.1\|WP_137799069.1\|2449706_2450396_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380058
NZ_CP039432.1\|WP_137799072.1\|2460631_2461309_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP039432.1\|WP_137799065.1\|2445466_2446711_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|380079
NZ_CP039432.1\|WP_137799056.1\|2433813_2434641_+\|thioesterase-family-protein	unknown	unknown	gnl\|CDD\|379298
NZ_CP039432.1\|WP_137799059.1\|2438531_2439086_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378427
NZ_CP039432.1\|WP_137799070.1\|2450474_2450888_-\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|234610
NZ_CP039432.1\|WP_137799068.1\|2448168_2449536_-\|dipeptidase	unknown	unknown	gnl\|CDD\|236127
NZ_CP039432.1\|WP_137799057.1\|2434653_2435997_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225179
NZ_CP039432.1\|WP_137799074.1\|2462009_2463242_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP039432.1\|WP_137799073.1\|2461579_2461963_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133388
NZ_CP039432.1\|WP_137799063.1\|2443602_2444202_+\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
NZ_CP039432.1\|WP_137799064.1\|2445185_2445413_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP039432.1\|WP_137799058.1\|2436565_2438263_+\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271370
NZ_CP039432.1\|WP_137799062.1\|2442318_2443437_+\|NDMA-dependent-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|274905
NZ_CP039432.1\|WP_137799071.1\|2450888_2460200_-\|DUF1729-domain-containing-protein	unknown	unknown	gnl\|CDD\|227315
NZ_CP039432.1\|WP_137799060.1\|2439105_2441136_+\|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl\|CDD\|239240
NZ_CP039432.1\|WP_137799075.1\|2463412_2464423_+\|ester-cyclase	unknown	unknown	gnl\|CDD\|377824
NZ_CP039432.1\|WP_137799061.1\|2441181_2441985_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223377

Protein	Function_ID	Function_description	E-value
NZ_CP039432.1\|WP_137799066.1\|2447327_2447549_-\|DUF3618-domain-containing-protein	gnl\|CDD\|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	2.54128e-11
NZ_CP039432.1\|WP_137799067.1\|2447691_2448162_+\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	3.00941e-72
NZ_CP039432.1\|WP_137799069.1\|2449706_2450396_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380058	pfam17928, TetR_C_22, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.	4.32091e-19
NZ_CP039432.1\|WP_137799065.1\|2445466_2446711_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	3.01307e-80
NZ_CP039432.1\|WP_137799056.1\|2433813_2434641_+\|thioesterase-family-protein	gnl\|CDD\|379298	pfam13622, 4HBT_3, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	4.61766e-54
NZ_CP039432.1\|WP_137799059.1\|2438531_2439086_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|378427	pfam10400, Vir_act_alpha_C, Virulence activator alpha C-term. This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (pfam03551), which is a transcriptional regulator.	2.71169e-25
NZ_CP039432.1\|WP_137799070.1\|2450474_2450888_-\|holo-ACP-synthase	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	1.74521e-40
NZ_CP039432.1\|WP_137799068.1\|2448168_2449536_-\|dipeptidase	gnl\|CDD\|236127	PRK07907, PRK07907, hypothetical protein; Provisional.	0
NZ_CP039432.1\|WP_137799057.1\|2434653_2435997_-\|MFS-transporter	gnl\|CDD\|225179	COG2270, COG2270, Permeases of the major facilitator superfamily [General function prediction only].	4.70253e-113
NZ_CP039432.1\|WP_137799074.1\|2462009_2463242_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	9.82511e-54
NZ_CP039432.1\|WP_137799073.1\|2461579_2461963_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	6.69235e-32
NZ_CP039432.1\|WP_137799063.1\|2443602_2444202_+\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	1.36872e-118
NZ_CP039432.1\|WP_137799058.1\|2436565_2438263_+\|sodium:solute-symporter-family-protein	gnl\|CDD\|271370	cd11476, SLC5sbd_DUR3, Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain. Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	8.20955e-113
NZ_CP039432.1\|WP_137799062.1\|2442318_2443437_+\|NDMA-dependent-alcohol-dehydrogenase	gnl\|CDD\|274905	TIGR03989, Zn-dependent_alcohol_dehydrogenase_class_III, NDMA-dependent alcohol dehydrogenase, Rxyl_3153 family. This model describes a clade within the family pfam00107 of zinc-binding dehydrogenases. The family pfam00107 contains class III alcohol dehydrogenases, including enzymes designated S-(hydroxymethyl)glutathione dehydrogenase and NAD/mycothiol-dependent formaldehyde dehydrogenase. Members of the current family occur only in species that contain the very small protein mycofactocin (TIGR03969), a possible cofactor precursor, and radical SAM protein TIGR03962. We name this family for Rxyl_3153, where the lone member of the family co-clusters with these markers in Rubrobacter xylanophilus. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP039432.1\|WP_137799071.1\|2450888_2460200_-\|DUF1729-domain-containing-protein	gnl\|CDD\|227315	COG4982, COG4982, 3-oxoacyl-[acyl-carrier protein].	0
NZ_CP039432.1\|WP_137799060.1\|2439105_2441136_+\|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl\|CDD\|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0
NZ_CP039432.1\|WP_137799075.1\|2463412_2464423_+\|ester-cyclase	gnl\|CDD\|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	1.46128e-31
NZ_CP039432.1\|WP_137799061.1\|2441181_2441985_+\|SDR-family-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	7.19548e-104

>NZ_CP039432.1|WP_137799065.1|2445466_2446711_-|L,D-transpeptidase-family-protein
MNGSGGREGRRGGGRRRPGSSAVVVAVAAALGMVMLVTGCTISTSSAGTADSASGSIDSNPLVALIQPKLTTSVLDGAVGFSPGTPVTVRVADGRLANVTLRNPEGRVVAGAVAPDGLSWTNTEQLGYSRRYTLQADAYGLGGATSTTMSFTTSSPGNVTKPYVMPGDGSVVGIGQPVAVQFDENIPDRRAAEAAIEIVTVPPVEGAFYWLNNREVRWRPQNYWAPGTTVTVDVKAYGRDLGKGLFGQEDVHSSFTIGDAVVIRADDDTKQVTVNVSGRDVKTMPTSMGKDSTPTDNGVYIVGDRFDHLVMDSSTYGVPITSPDGYRTPVDWATRMSYSGIFFHSAPWSVGEQGYSNTSHGCLNLSPANAKWIYDNTKRGDIVVVENTVGGTLSGTDGLGDWNIPWETWRAGNA
>NZ_CP039432.1|WP_137799064.1|2445185_2445413_-|hypothetical-protein
MEKVGAGDLVQAAGHAGPWTVLEVRHGMALLEHADGHRLSRRTTTLTVVRKAEPGTPAAESVGDSEGGDAPTLFD
>NZ_CP039432.1|WP_137799063.1|2443602_2444202_+|oligoribonuclease
MQDKLVWIDCEMTGLRLGSDKLIEIAALVTDSELNILGDGVDIVIHADDDALAAMPDVVREMHARSGLTEEVRASTVTVAEAEEMVLAYIREHVPVAGTVPLAGNSIATDRGFIARDMPALDMHLHYRMIDVSSIKELCRRWYPRIYFGQPEKGLSHRALADIKESIRELQYYRRTAFVADPGPSSAEIAAVAKELGPA
>NZ_CP039432.1|WP_137799062.1|2442318_2443437_+|NDMA-dependent-alcohol-dehydrogenase
MKTRAAVITEAPGTYKVVDLELEGPRQNEITVKMVASGLCHSDDHIAKGDHGVGRYPICGGHEGAGVVVEVGPHTLGWEVGDHVVFSFLAGCGRCRWCAKGLQNLCDRGAAIMTGGRPDDPNSYRLTLDGAPVAQTCGLGTFSEYTTVSIDSAVKVDKNLPLESLCLLGCGVGTGWGAAVNSAQVYPGHTVIVMGVGGIGINAVQGAAHAGASHLIAVDPVQFKREAALEFGATHAVATMEEATEIARSFTNGQGADAAIVTVGVTTGEHVAQAFSSIRKAGTCVVTGLGKMEDVGLPISLLELTLYQKRIQGSLFGASAPSADIPWMIELYKAGKLELDKLVTTTYKLDDIAQGFVDMHEGKNLRGVVLFD
>NZ_CP039432.1|WP_137799061.1|2441181_2441985_+|SDR-family-oxidoreductase
MSLPNPTPDARAVVTGASSGIGEALAAELAARGHSLLLVARRGDVMEKLAARLREQHGVEVEVRAVDLSDRDGRAPLVAELAEREISILCNNAGIATFGPVVDLDPAYERDQVELNAVAVHDLTLAVLPGMVARKSGAILMVGSAAGNMPIPNNATYAATKAFVNTFSESLRGELKGSGVNVTLLAPGPVRTETPDPAEASIVDKLVPDFLWISSEYVAKVSLDALAQNKMRIVPGILSKGMSAAGQYSPRAVMAPIVGTFYKKLGG
>NZ_CP039432.1|WP_137799060.1|2439105_2441136_+|NADPH-dependent-2,4-dienoyl-CoA-reductase
MTAPFPHLLAPLDLGVTTLRNRVVMGSMHTGLEDRAKNTARLAEFYAERARGGVGLIVTGGYAPNRTGWLVPFGAKLTNRVEARRHRTVTRAVHDAGGKIVLQILHAGRYSYQPLSVSASSIKAPINPFRPRRLTGRGVRWQIRNFVRCARLAHAAGYDGVEIMGGEGYFVNQFLCERTNKRTDEWGGTPDRRRRLAVEIVRRTRTAVGPNFLISFRLSMADLVEGGQTWDEIVALAKEVETAGATIINTDIGWHESRVPTIVTSVPRAAFVDVTEKLAKHVSIPVVASNRINMPEVAEEILTRGEVQLISMARPMLADPMWVRKAAAGAPDEINTCIACNQACLDHAFVNKHVSCLLNPRAGRETELTLLPTRRKKDLAVVGAGPAGLSAALNLAQRGHAVTLFEARDEIGGQFGIARKIPGKEEFAETIRYYRRQLDLAGVDVRLGTRAAAVDLIDAGYDEVVIATGVTPRIPDIPGIDHPKVLSYADVVRDGKPVGASVAVIGAGGIGVDVSEFLTHDHSPTLDLRSWRQEWGVTDPEAAPGALTVPRPAPSPREVFLLQRKPGRIGAGLAKTTGWVHRAALKAKGVQELSGVNYERIDDAGLHITFGEQHERPRTLAVDTVVICAGQESVRELVDDLTVAGITTHVIGGADVAGELDAKRAIEQGTRLAARI
>NZ_CP039432.1|WP_137799059.1|2438531_2439086_+|PadR-family-transcriptional-regulator
MALEHAILVALSEQSGSGYELARRFDRSIGFFWSATHQQIYRVLKRMDDAGWVRGESIAQDGRPDKKVYRVSSAGRAELARWIAEPTEPAHLRNELAVKIRGASYGDTASLLAEVRRHRDEHAARLDLYERIARHDFPATRRRTGRALHQYLVLRGGIRIEEGFVAWCDEVLGALTADSTREPS
>NZ_CP039432.1|WP_137799058.1|2436565_2438263_+|sodium:solute-symporter-family-protein
MDAPELVQFSAVAIILLLLFFYGGTFLVSLRIGRKNENADNFMTAGNQVGFGISAASMTATWIWASSMYASATSGYTYGISGPIHYGLWGALMILFIYPFGRRIRALAPRAHTLAEIMYARHGRSSQLMLAGSNVVGSLISLMSNFIAGGVLISLLSPLNFIQGVLVIAGGVLLYTLWSGFRASVLTDVIQLLGMLGAVVVLIPIVFFAAGFPAAFETGAANLTPAQGNFFSSEAFFNQGAPYIAAVLAYAIGNQTIAQRLFAVREDLIKPTFVTAAVGYGATVIGIGMFGVLALYLGLDPLDGDVNNLIPQIAGTYLPAVLVALFFLLVLGALSSTADSDLAALSSIVMTDGYGHTVAGREGADPRRMLLVGRATMVVATALAVAFASMRLNILDLLVFVGALWGALVFPVIASFYWNKVSNKAFTVATIAAVAAFLPVRFGWLPTDGASGFVIDVTAVVGVGVVLGLMAFGFFGLRVARIVGVVAIAITAPFGIGFLHDYATLSGSLVAYAVSTVVCFAMSVRNTESFDFATIEDRVGDFDRQAHVDDLDDDRPARGAAPARP
>NZ_CP039432.1|WP_137799057.1|2434653_2435997_-|MFS-transporter
MSAELVGEAGIGRASTRRQVAAWGLWDWGGAAFNAVVLTFVFSVYLTDAVGDDLPGTVSASTWLGWSLGIAGFFIAVLAPVSGQRFDATGRRKRSLAVLTFSTVAAMAAMFFVVDDYHYLWLGLVLLGFASVIFELAGVPYNAMMRQVSTPENIGRVSGFGWAMGYFGGIVLLLVCYLGFIAGDGPTRGFLDITTDGGLNIRLVALLAAVWLAVFAVPVLLMVPEAPRTAADPGAARAGFVESYRVLWRDVRELWAVDRRTVGFLIASALFRDGLAGVFTFGAVLAVNVYGLASDSVLLFGVAANVVAALGAIVAGRFDDRIGPKVVIVASLAAMLAVGVVLLAVSGPAMFWVFGLLLCLFVGPAQSSARTFLARLTPPGREGQMFGLYATTGRAVSFLAPTLFGFFAWWFGADRAGIVGLLVVLGVGLAALLAVRAPERDAEGLPG
>NZ_CP039432.1|WP_137799056.1|2433813_2434641_+|thioesterase-family-protein
MTQIAAPTHPFDAAVELTARTGAPDAYRGHTSPAYANMVGPFGGVTAATLLRAILQHPERLGEPLSLTVNFAGPIADGEFEVTARPTRTNRSTQHWNVELVQDGAVTTTATAVFGRRRETWDSTEIAAPPAPSAHDVAVHEFPDFIAWARNYELRFVEGAVPEPDAGAQPGSTSTLWVRDNPPRPLDFPALTALCDVFYPRAFLRLGRYLPAGTVSLTVYFHADATLLAAQADDAVLATARAQRFGKGYFDQSGEIWGRDGALLATTHQLVYFKD
>NZ_CP039432.1|WP_137799066.1|2447327_2447549_-|DUF3618-domain-containing-protein
MPRDTEAIERDIENARNQLAQTLDVLAVRTNPKRLVESTKQGVLAKLNEPAVRAALIGAGAIVGLLVVRKLFR
>NZ_CP039432.1|WP_137799067.1|2447691_2448162_+|thioredoxin-dependent-thiol-peroxidase
MTDNRLAPGDIAPDFTLPDADGNDVSLADYRGRKVIVYFYPAAGTPGCTKQACDFRDSLAELNGSGLDVVGISPDKPAKLAKFRDNEELNFPLLSDPEKATLTAWGAFGEKKMYGKVVQGVIRSTFLVDEDGKIEVAQYNVRATGHVAKLRRDLSV
>NZ_CP039432.1|WP_137799068.1|2448168_2449536_-|dipeptidase
MVTEQSDEVRGRVAALMPTAREELAALVAFRSIADPRQAPPEECLGAANWVADAFRAVGIGDVELIETSDGSTAVVGHRPGPEGAPTVLLYSHYDVQPAGDEALWETPPFELTERDGRWYGRGAADCKGNLVMHLLALRALGLPDAPAPVGIRVVCEGSEEMSGGGLEDLVRARPDLFAADVVLVADTGNTAVGQPAVTVSLRGVANVVVHVETLRSQLHSGMYGGPAPDALAALVQMLSTLRDHGGNTVVDGLDTAQDWIGAEYPEERFRADAGVLDGVRLTGSGSVADAVWARPALTILGIDAPPVVGSAAAIQPRASARLNLRVPPGMTPVHAQDALIAHLEKAAPWGARVRVERESVGEPFRTSTTGPAYVALSEALAAAYGVAASPIGEGGSIPLCNVLGDQFPDAEILLLGVEEPAAFIHAPNESVDPTEIENLAVAEALFLRSLGDRT
>NZ_CP039432.1|WP_137799069.1|2449706_2450396_+|TetR/AcrR-family-transcriptional-regulator
MESTTSRRPPRRVDPALEVQSDPQELMPRKRPTQERSRRKFDALLNASRELLVDVGFESFTCEEVAARADVPIGTLYQFFANKYVIVCELNRQDLVGVQQELEAFSGEVPSLDWLRFLNTFVDHMAGLWTSDPSRREVWLAMQSTPSTRATGVIHEKQFAERVTRMLAPLTPHTPHERRTMMAEVLVHVVYSMLNFSVQDGQSHADAVAELKRLMVAYLLVAEKEARSK
>NZ_CP039432.1|WP_137799070.1|2450474_2450888_-|holo-ACP-synthase
MAVLGIGFDVVTISEFAEQLKRPGTAMKSSFRPAERRYCESRSTDPARHYAVRWAAKEAVIKAWAASRFARPPAVGDNAYVLVEVVNDAWGRPTIKLHGEAAEFLPSAKIHLSLTHDGDVAGAMVVIEEPDPIAPIG
>NZ_CP039432.1|WP_137799071.1|2450888_2460200_-|DUF1729-domain-containing-protein
MTIDDTAGNGRTPKEPSQFGADRAPVRSAAQGPLVDRLRAGEPYALAFGGQGAPWLSALAELTRDSGLEPTLTELVNDAAAILEPVAQDLLVVRPVGFDPIAWILEQELADDEDTTGAAVPSAAALTSAAVSLPGVFLTQLAALRALQQQGLDPEINAPVATIGHSQGLIAAAAVAGAGAADSALLATAQLIGAGAGLVGRRRGIIAAADRSPMLAVSNVDPERLSAIVAELAQGQEPERAAVMAIRNGRRRVVLSGPPAQLARVQQRLEQIAAEESRERDAKTRGGAVFSPVFESLPVEIGFHHPALAEAVELIGGWATRCGLDAEQVRALAQAVLVDPVDWVDAVEGAIESGAAWILDLGPGDLLTRMTSTGVRGRGVGIIAASTRGGHRNLLTPGAAPEVARAWTEFAPKAVALPDGRVAVETAFTRLTGRSPILLAGMTPTTVDPAIVAAAANAGHWAELAGGGQVTEQIFADHVEKLKGLLEPGRAVQFNSMFLDPYLWKLHVGGKRLVPRARAAGAPFDGVVVTAGIPELDEAVTIIDELTEAGFSYVAFKPGTVAQIRSVIRIANEVPNFPIIVHIEGGRAGGHHSWEDLDDLLLDTYAELRARDNLVLCVGGGIGTPERAAEYLTGRWSTAYDFPAMPLDGILVGTAAMATLEATTSPDVKQMLVDTPGTPDWVGAGTAQGGMASGRSQLGADIHEIDNAASRTGRLLDEVAGDADAVAARRDEIIAALDVTAKPYFGDVAAMTYQQWLRRYLELAVGVDSAQAFDCGGDVQDAIADATQSVWLDVSWRDRFGEMLQRAEARLHRNDRGPIRTLFADSTTLDRPFAALCALEAAYPDYADTVLHPADVAFFVSLCKTPGKPVNFVPVVDADVRRWWRSDSLWQAHDPRYTADQVCIIPGTVAVAGITRVDEPVGELLDRFEKATADELVAAGADPAPIAGRRHGGFGTGLLDAVLTAPDVLWAARLTQNPVRRLGEVAEWTVESDTVASHDKTGARLVVVDAEHVELTVPLAQGKAVEIRITVPATVRDGGAPVVTEADAEASMAALLGVAAGQELPTVKGGVAHINLAWTPDLIADHAGVTGVGLPVNLSTSGKAVPDVVVGACWPAVFAALGAATTESGVHVIEGMLDLVHLDHAVDLVGELPSETSILVVRAEAGDVVDTDMGRVVEVRVEVGAMLGEGLEAPAVAVLTERFAIRGRTGKGELADPARAGGSLSADVAETPRRRRRDLTMVAPRNMAAFARVSGDHNPIHTSDAAALLAGLGTPIVHGMWLSAAAQQAVTAVDPESKVPARRLTAWTARFLGMVRPGAEIDVRVDRVATDHGDEIVEVGCRVDGDLVMVATGRTAAPKTVYAFPGQGIQRPGMGLDARSRSKAAREVWERADKHTRAALGFSILAVVRDNPTLVKARGVEHRHPDGVLHLTQFTQVAMATLGVAQVAELRESGAFVEGSYLAGHSVGEYNALTAVAGVLPLEALLEVVFQRGSAMHELVPRDAAGRSDYRMAAIRPSQIGVADDELQAFVGGVADATGEFLQIVNLNLKGSQYAIAGTVKGLAALEREIDIRREAFGGKRAFIVVPGIDVPFHSTVLRGGVDDFRAKLDELLPQEIDPALLIGRYIPNLVPKLFNLGRDFVQEIADLVPSDQLQAVLADFDSWAERPVALTRVILVELLAWQFASPVRWIETQDLLFTDEDAGGLGVERFVEIGLGATPTVANLAAQTLKLDEHAGTKVEVLNIEREASVVYSTDVDPAPVEEDPADDSAEAPAAPAAAAPAPVAAPAAPAGGPRPDDIAFKAADATKVLIALWTKLRPDQIGPADTIEALCDGVSSRRNQLLVDLGSELSLGAIDGAADADMGSLAVTVDRLARTYKPFGPVLTDSINDHLRKVFGPSGRRPGAIADRVKKVWELGDGWAHHVTAEVALGTRDGSSVRGGAMGGLHEGAIADGAAVDALVDAAVQSVASRRGVAVSMPAAGGGAGGTVDAAALGEFTEAITGRNGVLASAARLVLEQLGFSESAAAAVAADDTALVDLVSAELGSDWPRLVAPAFDAKKAVLIDDRWATAREDLARGWTGEIDLTVERFDGAGTAVANHAQWWQQRATAEGRTTLAELYGRIAQVAIAPLEKKGRYTGEIAIVTGASKGSIAASVAGKLLGGGATVVVTTSRLDSERLGFYRKLYSANARAGASLWVVPANMASYTDVDALVEWVGNVQTETAGGAKKLVKEAMTPTMLFPFAAPRVAGELSDAGARAEMEMRVLLWSVERLIGGLSQIGYDRDVDTHLHVVLPGSPNRGLFGGDGAYGEAKAALDAVVGRWSAERTWAERVTLVHALIGWVRGTGLMGGNDPMVEAVEAKGVRTWSTDEMATELLSSCTAEVKRAAAQAPRVVDLTGGLAEVDLDLPALAKEAAEAAEKAAETRDEAAEDANSIAALPAPPRAVVAPAVSSWPELDVDPADLVVIVGAGELGPYGSARTRFEMEVDEQLSAAGVLELAWNTGLVAWENDPTPGWYDTETGELVPEAEIADRYHDTVVERCGIRTYGDEGAMVDNTAPLLTSVFIDKDLSFVVGSEAEARAFVDSDPENTVAAVDPESGDWTVTRKAGTEIRVPRKVKLTRTVGGQIPTGFDVTKWGIPADMAGSVDRVGLWNIVSTVDAFLTGGFTPSELLRWVHPSFVANTQGTGMGGMTSMRSLYIDTLLGESRANDILQEALPNVIAAHVVQSYVGGYGAMVHPVAACATAAVSVEEGVDKIKLGKAKLVVAGGFDDLGIEGIVGFGDMSATAKSDEMAAKGIDDRRFSRANDRRRGGFVESAGGGTILLARGDLALEMGLPVLGVVAWAGSFADGVHTSIPAPGIGALGAGRGGQDSQLALSLNALGITADDISVVSKHDTSTAANDPNEAELHERLAAALGRSDGAPLFVISQKTLTGHAKGGAAAFQLIGLCQVLSQGVVPPNRSLDCVDDKMAEFSHFVWPRTPLRFGNQFALKAGLLTSLGFGHVSGLIAVVHPQAFVESIPANQREAYLTQAQQRTIDGQRRLASAMCGGEALYERPADRRFGGDAVPAKAARQLEADMLLTEEARLGDDHVYRAGQPGCR
>NZ_CP039432.1|WP_137799072.1|2460631_2461309_+|hypothetical-protein
MGGTMKHNAVRTLAAVAGDVLPGGHTLWPAGWPGEIEAALLDAVFSARATYGTPTSGVRRVVTAWRAHRGTRLDDLTALASFTSAPDRLAAVLGNRQRVPGNYTTKAEAAAAAAAALVTSGIDSSGRIGDGRNAWDALTGVPGLGTTTWETFVLQLGLVGPLALGEICGFVAAALDDGRSDIPETEALGLLGAAAASLDVPQTALLNAVWRSRRTRGPARKPLSA
>NZ_CP039432.1|WP_137799073.1|2461579_2461963_-|MerR-family-transcriptional-regulator
MRIGELSRRTGLTPRMLRYYEQQGLLQPNRSANGYRDFSERDVERAQTIRDLVTSGVPTRLIPAVLDRRDGARVGWTGECDRILAGQLSSEIESLDSRIACLTRSRNALDELLGLGPVQLRSERADN
>NZ_CP039432.1|WP_137799074.1|2462009_2463242_+|MFS-transporter
MTDTEGSTTPKTAPTRQLPTPPPATPSMPWTVLIALTFASFATVTMEMLPSGLLPQIGRGLAVDPALAGTLVTAWALTIVVTGVPLVRVTAGVRRTRLIPAALGVVAIAGLVTASAPSFGVALAGRVLAAAGHGVFWALIVVHVADTVAPERLGRALAIVLSGPTIAGCAGLPVATALVDTVGWRGVFAGASVVSALVAGALVPILADTETSGPRPRSVIRWDRSAILCLGTALAAALVLVGHFVLFTYVSLVVTDVAGFDSGAVAAVLVLFGAAGAIGVAISGWLSDRWPSATLPVSAFAALTAFAMLAAAPAVPAVFVTTIVLWGTVVGVLPAAMQVRVLRLASPEFRPAAGSVVVTVLNLGIAGGAALGGLTVGFGVAELAPVAAVVTSVGALCLSLSARVPARVTE
>NZ_CP039432.1|WP_137799075.1|2463412_2464423_+|ester-cyclase
MSTRLLTDSVHTAVIDVPARRVDIAEWLYSLSDAEYRRCCPPDHLTTGVGASEDGRPIWIGVETIDDALLIHHFVGAVTDPHHCRMVSTSEVVSAAGRTTVDVTWELRAEPDGDGRCTVTDRILVSPTGDYFAHLDERGIVFEDAAAACAAAYGDHVRRETPLLADSIGRRAANSNGRHAAVSPTAVPLATTSTGETDGAAAKAVIRRNAEEVHGSGDFAVFDELFADDYVDHTPHPGLAPDKSGTKLLYQSMRGAFPDLRAEIHWQSVDGDLVTTYLTYHGSHRGAFLGIPPSGRPAAFDAVDVMRVRDGRIVEHWGSAHLPALPSRIDAAGATP

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Crispr_ID: NZ_CP039432_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP039432_2

3389688-3389783

Orphan

Consensus_repeat	Method
GGCAAGGGCCTGCAGATGAAGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP039432_2

>merge|NZ_CP039432|2|3389688-3389783|CRISPRCasFinder
GGCAAGGGCCTGCAGATGAAGGGCCTTGCCAAGGCGCCGGGCGCGAAGGCGCCGGGAGCCAAGGCTCCGGGTGGCAAGGGTCTGCAGATGAAGGGC

>NZ_CP039432|2|2|3389688-3389783|CRISPRCasFinder
GGCAAGGGCCTGCAGATGAAGGGC	CTTGCCAAGGCGCCGGGCGCGAAGGCGCCGGGAGCCAAGGCTCCGGGT
GGCAAGGGTCTGCAGATGAAGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP039432.1\|WP_137799797.1\|3369662_3370559_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182137
NZ_CP039432.1\|WP_137799815.1\|3399263_3400724_-\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|349772
NZ_CP039432.1\|WP_137799800.1\|3373942_3375763_-\|Isoniazid-inducible-protein-iniA	unknown	unknown	gnl\|CDD\|206739
NZ_CP039432.1\|WP_137799817.1\|3419718_3421626_+\|DUF4012-domain-containing-protein	unknown	unknown	gnl\|CDD\|379067
NZ_CP039432.1\|WP_137799801.1\|3375912_3378456_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP039432.1\|WP_137799811.1\|3394737_3396000_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181738
NZ_CP039432.1\|WP_137799808.1\|3390842_3391784_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP039432.1\|WP_137799798.1\|3370682_3372452_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223839
NZ_CP039432.1\|WP_137799799.1\|3372467_3373946_-\|Isoniazid-inducible-protein-iniC	unknown	unknown	gnl\|CDD\|206739
NZ_CP039432.1\|WP_137799805.1\|3384719_3386054_+\|protease	unknown	unknown	unknown
NZ_CP039432.1\|WP_137799804.1\|3383177_3384566_+\|protease	unknown	unknown	unknown
NZ_CP039432.1\|WP_137799813.1\|3397563_3398526_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212674
NZ_CP039432.1\|WP_137799806.1\|3386125_3386803_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP039432.1\|WP_137799814.1\|3398622_3399147_+\|low-molecular-weight-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|319972
NZ_CP039432.1\|WP_137799809.1\|3391872_3393837_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP039432.1\|WP_137799803.1\|3380535_3383064_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP039432.1\|WP_137799812.1\|3396269_3397559_+\|YibE/F-family-protein	unknown	unknown	gnl\|CDD\|377940
NZ_CP039432.1\|WP_137799816.1\|3400779_3419562_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
NZ_CP039432.1\|WP_137799810.1\|3393875_3394286_+\|TIGR03668-family-PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132707
NZ_CP039432.1\|WP_137799802.1\|3378742_3380533_+\|Hsp70-family-protein	unknown	unknown	gnl\|CDD\|212667

Protein	Function_ID	Function_description	E-value
NZ_CP039432.1\|WP_137799797.1\|3369662_3370559_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|182137	PRK09906, PRK09906, DNA-binding transcriptional regulator HcaR; Provisional.	2.79218e-27
NZ_CP039432.1\|WP_137799815.1\|3399263_3400724_-\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	4.61251e-71
NZ_CP039432.1\|WP_137799800.1\|3373942_3375763_-\|Isoniazid-inducible-protein-iniA	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	1.23882e-14
NZ_CP039432.1\|WP_137799811.1\|3394737_3396000_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_CP039432.1\|WP_137799798.1\|3370682_3372452_+\|penicillin-binding-protein	gnl\|CDD\|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	5.94059e-57
NZ_CP039432.1\|WP_137799799.1\|3372467_3373946_-\|Isoniazid-inducible-protein-iniC	gnl\|CDD\|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	8.68236e-15
NZ_CP039432.1\|WP_137799817.1\|3419718_3421626_+\|DUF4012-domain-containing-protein	gnl\|CDD\|379067	pfam13196, DUF4012, Protein of unknown function (DUF4012). This is a family of uncharacterized proteins found in archaea and bacteria.	2.18822e-59
NZ_CP039432.1\|WP_137799813.1\|3397563_3398526_-\|hypothetical-protein	gnl\|CDD\|212674	cd10232, ScSsz1p_like_NBD, Nucleotide-binding domain of Saccharmomyces cerevisiae Ssz1pp and similar proteins. Saccharomyces cerevisiae Ssz1p (also known as /Pdr13p/YHR064C) belongs to the heat shock protein 70 (HSP70) family of chaperones that assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Some family members are not chaperones but rather, function as NEFs for their Hsp70 partners, while other family members function as both chaperones and NEFs. Ssz1 does not function as a chaperone; it facilitates the interaction between the HSP70 Ssb protein and its partner J-domain protein Zuo1 (also known as zuotin) on the ribosome. Ssz1 is found in a stable heterodimer (called RAC, ribosome associated complex) with Zuo1. Zuo1 can only stimulate the ATPase activity of Ssb, when it is in complex with Ssz1. Ssz1 binds ATP but neither nucleotide-binding, hydrolysis, or its SBD, is needed for its in vivo function.	0.000680504
NZ_CP039432.1\|WP_137799814.1\|3398622_3399147_+\|low-molecular-weight-phosphatase-family-protein	gnl\|CDD\|319972	cd16344, LMWPAP, low molecular weight protein arginine phosphatase. Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.	5.30474e-36
NZ_CP039432.1\|WP_137799809.1\|3391872_3393837_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	4.27588e-54
NZ_CP039432.1\|WP_137799803.1\|3380535_3383064_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.87895e-14
NZ_CP039432.1\|WP_137799812.1\|3396269_3397559_+\|YibE/F-family-protein	gnl\|CDD\|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	6.02537e-83
NZ_CP039432.1\|WP_137799816.1\|3400779_3419562_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP039432.1\|WP_137799810.1\|3393875_3394286_+\|TIGR03668-family-PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|132707	TIGR03668, Rv0121_F420, PPOX class probable F420-dependent enzyme, Rv0121 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	8.42466e-48
NZ_CP039432.1\|WP_137799802.1\|3378742_3380533_+\|Hsp70-family-protein	gnl\|CDD\|212667	cd10170, HSP70_NBD, Nucleotide-binding domain of the HSP70 family. HSP70 (70-kDa heat shock protein) family chaperones assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. HSP70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Some HSP70 family members are not chaperones but instead, function as NEFs to remove ADP from their HSP70 chaperone partners during the ATP hydrolysis cycle, some may function as both chaperones and NEFs.	4.05177e-40

>NZ_CP039432.1|WP_137799806.1|3386125_3386803_-|hypothetical-protein
MKLRRIAATSVLVTAALGVGTGTSYAAPAPAPNPIGYQAHVEDRSVVTLLDAGGFHLTSDGRFVEITDDAGTVLQTLPLTYRLGDREFSIAPLVDGRKLTLTPEIAPARAVAADVAEPIDPANLAALGENLKVFEKLSEGVSEAVTTGSLVGTLVGAVVGCAIGGTPLALTGVAIPQAVLLCLGGAAAAAPVGGMIGTIVAGVPVLAYNGWQVYQTLNAAPPAAG
>NZ_CP039432.1|WP_137799805.1|3384719_3386054_+|protease
MRSSLARRAAVFGSAALLLLGPATAVAQAQPAESPAVAESGVSDQAAHLPIELIDALQRDLQLTPDQYLQRSALAQKLAEFAEIARIQFPDAFAGAWIDPSGAPVVGLAHAGRGDARAAVEQAGFTAKDVERSQSQLESTRSALSDWIGTLPPEIAKFVRGVTVDIANNDVVLRADDTAGDVLDLLPPELREAARVALGPALASLQPAAPGQATAQYAADAFLGGDPYVANGGGMGLKCSLGFNAIDGGGAPVNISAGHCDPNRTFAGTEHASQAYAAVGDLSGPMIGTFERTSLDGSDYSIIRPAAGTAQRFANNGVRVPNAAPVAITGTADPVVGAPVCKAGNTSGFNCGVVTAVHQTVPVGQRVINDGFATNLCALQGDSGGPIVTGTLALGISSASNVGDYGMCEIANFATSAMGEAPELFATPINAILGQNPGLRIRTS
>NZ_CP039432.1|WP_137799804.1|3383177_3384566_+|protease
MRTSLAQRAAVQSIARRAAVLGSSVVLLAVPFTASAHAEPSDSGDSARTSVTQLSADELPADLVEAITRDLRISPQEYLDRAARAQELDSYAADFRNEHPDAFAGAWMGLDGHPVVAVTTTEAAQTATRDGYRTQLAPVSADGLDRALADFNQWVSDLPRQVASQIGNATVDVLNNQIVVDIVNSPIGRAIDLPTHLANVKVQLQSLGGPVPVERSPMGGDTYVTTPGPISAAGEGEVGVCSFGFSGVDRGGNAVNISAGHCDPAPGSGAGVYLPDRANVAASQRIGSFARSEVGGSHALDYSLIRLDDAGTRAGLDRPVIRGAGGSTLTVTGTAVPVVGAPICKSGQTSAFTCGVVSADRVEASLEMLDGTSRTVRGFSGTACTLAGDSGGAIVTGTLALGITSGSNSSYAATCAEANAVLAFDGGTSNLGTPIRDVLAAADATSGGGIGAGLTVRTAAAN
>NZ_CP039432.1|WP_137799803.1|3380535_3383064_+|LuxR-family-transcriptional-regulator
MQTARAGRPAEPGDDPAPGLAGVPGARDLLDALASPGPACILVRGNSGSGKSLLLAAARNTLSADGRRVVSTLDGAAGDDPLVLGAAHTLADDALATVCALVRQSRRTVVVATEPRPHRTPLTDLISTMHAHGTVIDLRPLAPADVVARARRRGIALTPGLTRTLHDSSAGLLAAVDAGLDAAEVAGADDAAVRSAVTSYLQSALRHLDADMLSALALCAHGFGLDTVDLSAVLDLPPDASRDLADRVRASAFVSRADAAAPAVRALVGATIGVTRLRELQSRLLTARLDAATLDAPTALAFADAGLDDPRLARFLCGCADSAEPARAAALLAAAVRAGADARSLALRRAEVSALSGDLDTAEALADAALDRADALDGAELVAAVRISASVAACRGAVARSADLYEWLGPDRVGTDAAIASTVLLAAGRPDAAGASAAGGRPGPPTSGAAGVALLAEGLRQSVTGAGALAMNSLTRAMSLLNTSVHTRLLPDTATAVTALLCLHSGELAHADSVLRRALESDPPSSVARTRHLVLSAWTAMVGGDLAAAAALVDALPTDRTLPGREALFVHALRVGLARRNGDVGALQREWAAARPVVAGYSADLLSLLPLGELWLAAVRVGESGRIAHLVEQAQDLLSRLGEPALWGASLHWYGVQAAILGDNPSQLLPHARALAAAAEVSAYSAGLATAGRVWLRVLREEADAAEVESAARTLERIGLPWDGARLAGEAALRVSDTRGATTLLQVARSLRGTTGAPAPGADVVAAPEPTVGTLTDREADVARLLLLGHTHREIGARLYIAPKTVEHHVARIRRRLGANSRSELLSMLRALGYGTVEPSAS
>NZ_CP039432.1|WP_137799802.1|3378742_3380533_+|Hsp70-family-protein
MAAGLGIAVGTTNSVIAVAPDHASATDETAAVHSRPTALSVPTDGAPVLAGLDVSPTGTRVTGYVERVGDPVGLLDDSGRVHRGEDLFAATVTGLIATVHDEGDDTASADAVVVTHPTAWSAYTVSALESALDRAGVPDARLVPEALACVRWLESARGPQGDGVVVVYDLGGSGLDVTVVRTGAAPSVIGRPLHSEDFAGDSIDHLVTRLVLDGLAGRTADLDPFDAATTAALLDLRRRCTDAKEALSTDTETTLAVALPGLGTDVRLVRSELEDLIREPLTKSLELVREALRAAEIESSDVTAVLLAGGGGAIPLVAELVSSELGLTVVAAPEPARTAALGAARLAADVPAAAAAPAAVATAETVELPRAAAAPVVPAFPTRRHTTRDGSSMRRRVAVVASAAAALAVLTAGGLALGTSSAPPAQSSSPDIGTSTSTTAPTTGGDRPVTEPGTADAVTVGRTGTGTGTGTQAPAVAGAEGGAPAAGAAGTPATPGAPTSDGAPGAPAPAPAAPPATPSGTEPGGGTPPPVYPPSGGGPSAPVYNGPSPSEVGAGMGQVATGIGQGLGGVVTGIGTGVGNVVGAVVDPVTGLLIGQ
>NZ_CP039432.1|WP_137799801.1|3375912_3378456_-|hypothetical-protein
MASNAVLDFILRLLRDEDAAAAYCANPQGALTAAGLSDVCVADIAAVAPMVAESGLFGGAAGDLSAILAAGTGAAGSIGATAGGGLGGGLGAGLGLGGGAGLGAGAGLGVGAAVGGGLAGGIGGGLGGGFDFGGDLAAGLNAALAAGGAIGAQLGAAIGAAIEAAAGLGGSLDLGGLTDVAGSVDLGGALAAALGGALDIDGSLVTDLGAALGAAFEGIGGIDLDGLLSVDGALTAALENAFAIGGDLGGQLGTTLGAMFDAAIGAGADLGASLSGALESALASALSLAGGLDGDVLAGVGADLSGLLESALSLGGSIGADLGAALGGALELGGAFDLAQLVDIDAALDLGAQLGTAIGGSLGVDGDLAAQLGAALGAALDGAGSLDLTGLLEAGGGLTAALESAFAVGGDLGASLGAAFGSALEGAVAAAGDLGGSLESVLGGALGVGGDLGAALTGALESALTVGADLAAQLGGSVGADLTAALSGALETALASGGAVGAELGAALGAALDGGLGGSLDLDALVNAGGDLGAAISGALGSALDVDGALTTSLAAALDSALALGGNIEVGAGADLGGLLEGAFGVGGSAGADLGAALGGVLGGGLESGTALDLGALLGGDAGFGAELGGALSGLLGTGSTAGGDLGAALDAALGAGGGLGAVGDAAGELGGQLGGQVGGELGGQLGAGLGSTGDLGAGLGVDLGAGLSGAFDGMVDAATSAVADVSSGLDAGLAGGLGSTGAVDGGVGAELGGGFAGGLDAGFTGAGDIAADLTSGFDAALQGAVDTAAQLSGGANAWSTIDTDAFGSAQSDAGLFGGAVADLGDQLGAVVDPAPVHLDLGHDPLP
>NZ_CP039432.1|WP_137799800.1|3373942_3375763_-|Isoniazid-inducible-protein-iniA
MNDAMTSLLDRTVEIASSTGRHDLVQRLGLVRTRVVDPRFRVVVVGQLKQGKSQFVNSLLNLSVCSVGDDETTAVPTVVQNAADAFAELVLAEPGSEPRRVPVPLDRLDTVHPKMPLAEGREVLRLEVNVPSPLLADGLVFVDTPGVGGHGNPHAAATLGLLPAADAVLVLSDASQEFTEPELTFLRQVTGLCPATACLVTKTDLYPHWRRIVDVDREHLTRAGLDVPLLPISSLLRSHAMRLDDRSLHEESGFDALYAFLRTRVVEHAEGGLRRTVSLDVHSVVEHLQLALASELAALRDPEKGAAAVAELQRAKAATEELQKKTARWQQTLADGIADLASDIDHDLRDRLRQVTREAERAVDEGDPGKEWTELGEWLEQQIAQSVGDNFVWAHERALWLAEVVAEHFADAGAVELPQLDVADTDGLLEPVAELSDLESGRIGITQKVLVGMRGSYGGVLMFGLVTTLMGMALVNPISVGAGFLLGTKAYRDDRDARVVKRRADAKVAIRRFTDDVSFQVGKESKDRLRIVQRLLRDHFTAIAEQTLRSLADSLRAAQEAATVASAERSRRAAEVERQLAALTELKQRAAQLFPVEDAESRAATA
>NZ_CP039432.1|WP_137799799.1|3372467_3373946_-|Isoniazid-inducible-protein-iniC
MTTSLDRARALVAAARDAYPADAVARAQLAECAARLEQPLRIALAGSLKAGKSTLLNAFVGQDIAPTDATECTRVVTWYRSGHTPTVTARYDGDASAAVTVQRRAGRLTFDLGELTADRVDRLDVEWPASALTHTTIIDTPGTSSLSKDVSARTLEMLTPENAVSGADAVVYLLRSLSASDVQFLGRIGAHVGGESGPLGVVGVVSRADEVGAGRADAMMSAKDMAARFASELELTGLCQAVVPVAGLLALGARTLRQSEFAAFEALAAVPPDDLQLAMLSADRFAREDAALPVDAAMRRQLADRFGLFGIRLAVMLIRLGVTDSPTLAAELVARSGLDELRQVIDVQFGQRADQLKTHSALVALERVLETRPGPGTAAVLADVRRLLADVHGFQELRMLGRLRGTETGLGADDLTELQRLLGGFGIGAAQRLGVDPDIAPDAGRALALDAVRKWRERAAHPLVDQFTARACRVAARSAEGVLAELDGALQP
>NZ_CP039432.1|WP_137799798.1|3370682_3372452_+|penicillin-binding-protein
MTPVRWRSAVLAVAGTIALTSCGVFGPDSGETVARQFTEALAARDVDRAAALTDAPARAADVLRRTFDGLGDGAHGSFTVESASDALFTYRSTWDFGGGREWDYSTSVGLDSVGGNRRVAWSSAVVNERLRGEQALQYTTIADTRAVLDANGMALMEPRTVTVVDGDPKVLAADAAARTAVTTLLGRVVPGFTLPEPDPAAGWVNLVSLREEDAAPIRAQLETLRGVRVADRMQLLTVDREMTSPVVAGLRETWESRQRESAGWSVQAVDPDGSVTGSLAGGDPPSGTAMRTTLDPRIQHLAQRAVDTEPRASALVALDPGTGQVLAVAQNAAADKSGPIALTGLYPPGSTFKTVTTMAALRSGDVDADSVVDCPGTADIEGRRIPNENEFDLGRVPLHTAFAHSCNTTMGRLAVGLPADALREQAREFGLGVDYVTPGLTTVTGSVPSADTPAERVEAAIGQGQDLATPFGMAVVAAAIAAGRAPVPQLIGGEPATADHTPDPLDAAHVRDLKAMMAEAVRSGTATSLSDVSGLIGKTGTAEFGDGTHSHGWFVGIRGNVAFAVLVVSGESSGPALDIAGHFLRPLDD
>NZ_CP039432.1|WP_137799797.1|3369662_3370559_-|LysR-family-transcriptional-regulator
MNLLLHLEFFIAVAEEQHFGRAAARLGMTQPPLSQGVKKLERELGVTLFHRGAKGVRLTAAGQSLLPDAVDLVARARRFTESARRRGTAERTLRLGVMPKVPTALVADLVATVRAATPSGRVEVTIAPSVELIDQLGSGAVDVGVVEHPALVEPLVGGDVVALPLTLLVPATHPAAGHDPCELSRLGGLRLASPPRADGPAAYDLQGDVFARLGMDLDVVHAPDDRWALASVAAGHAFALTADPELTAPGVRRVRPDTESLRLRLRCLRAAAGDVPDDVLDAAAACIARFAATPGGPR
>NZ_CP039432.1|WP_137799808.1|3390842_3391784_+|hypothetical-protein
MDPHIVRRADALQRGASDWQLQFLCRNGSWHRLRRGAYMSTDRFADLGVRERHRARATATLRAASEEAVLSHQSAAIVHDIDLWRTPLAAVHLTRNRQSGGHRTPVRHLHCTSLHPQESTTVDGLRVTSAARTVVDLARTLPFEQAVVAGDHALHSGLCSSGDLAATDPRTARRRVAGVLRLLDGRSESVGESRSRVLMIREQLPVPDCQPNLYADDGKLLGRVDFLFAEHGVVGEFDGRAKYGRLAPDGHVPEEVVWAEKLREDAIRSAGWEVVRWVWDELDTPAVVVGRLLAAFDRSRARPTGRVERTPCP
>NZ_CP039432.1|WP_137799809.1|3391872_3393837_-|S9-family-peptidase
MTTPAPTVTPYGSWISPITAADLAASGHPVEGGVFVGDGVWWSEQRPVEGGRSAVRRLGPDGEPVDVLPPPWNARTRVHEYGGGAWAVTPDAVLVFAEFTDQRLYRFDPHVDAAPVPITPAPPTAAAHRYGDLTIVGDEVWCVRERHDDGVIVRDICAVPVDGRADDDPSALRSIVGGSIVGTSDFLAYPRVSPDGARVAWIAWNHPQMPWDGTELRVLDLASGAVDVLLGGPEESVLQPEWEDASTLRVVSDRSGWWNLYRVTVDGGDLQPLCPTGADFGAPLWQLGARWHVGLDDGAVLTARTVGTDTLAVLDPGTGALRDLELDGISSVGICDVDGNRILLRCGGSRIASGLRILDLDSGALTDVRLSVDTLPDVEYLPEARALTFDGPEREVHAIVYPPRNPDHVAPDGELPPYVAFVHGGPTAHVAPAVHLVYAYFTSRGIGVVDVNYGGSSGYGREYRNRLRGQWGVVDVEDTVAAVRGLADAGLADPRRLAIEGGSAGGWTVLSALTTSDVFACGVSYYGVAELVEFVKETHDFESRYIDGLIGPLPEAAELYERRAPVNNVDGLSCPVLLLQGLSDPIVPPSQAERFRAALVRKQLPHAYLAYAGESHGFRRVETIVNAREAELSFYGQVLGFDTPGIPRLELWRP
>NZ_CP039432.1|WP_137799810.1|3393875_3394286_+|TIGR03668-family-PPOX-class-F420-dependent-oxidoreductase
MSASVPPRFADAPVARLATVSADGTPHLVPVVFAVVGDALYTAVDDKPKSTRQLRRLANVAATGRVSLLVDHYDDDWTRLWWVRVDGTAEVLAVGAAEAERAIDALVAKYAQYRSMRPAGPVIAVRQRRVREWSAS
>NZ_CP039432.1|WP_137799811.1|3394737_3396000_+|pyridoxal-phosphate-dependent-aminotransferase
MGGVSTPDSPRPRRPQRTLEQSTKLQNVLYEIRGPVHAHAARLEAEGHRILKLNIGNPAPFGFEAPDVIMRDMIAALPYAQGYSESKGILSARRAIVTRYELVPGFPELDVDDIYLGNGVSELITMTMQALLDDGDEVLIPAPDYPLWTAMTSLSGGTPVHYLCDEQNDWNPDIADIESKITDRTKALLVINPNNPTGAVYSAEVLTQLVELARKHQLLLLADEIYDKILYDDAKHVSLATLAPDLLCLTFNGLSKAYRVAGYRSGWVAITGPKDHAAGFLEGLDLLASTRLCPNVPGQHAIQVALGGHQSIEDLVLPGGRLLEQRDVAWERLNMIPGVSCVKPRGALYAFPRLDPNIYEIHDDEKLVQDLLLQEKILMVQGTGFNWPDHDHLRIVTLPWARDLAVAIERFGNFLSSYKQ
>NZ_CP039432.1|WP_137799812.1|3396269_3397559_+|YibE/F-family-protein
MQSPSPGHGHGHGHFGGPVPLGPVAVRVVVGLLAAVAIVVLAGVVILWPGKQHVDVPLPFQNAGGGAVTTEAGTIVAQDISACGSPSAGRAFSGDPAPPPTSSGGIDCRRSLVTIESGPNAGTRTLLEIVPGPGQPQLNLGEHIRLVRQTDSSGTPFYAFNDYSRGFPLVLVVAAFVIAVVAVARWRGLRALLGLGITFGVLIVFTLPALLDGKPALPVALVSGAAILFAVLYLAHGVNLRTSAALLGTLASMLVAAVLSSVAIGMTHLTGLSEEQNTDVQAYVEHVSITGLLLAGFIIGSLGVLNDVTITQASAAFEIAAMDGSASRRTIFASAMRVGRDHIASTVYTLVLAYAGGALPLLLLFSVAGSPLGDVLTGDAVAIEIARSSVGGIALALSVPLTTGIAAMLARPPSTVPTAPRRRGGRHAR
>NZ_CP039432.1|WP_137799813.1|3397563_3398526_-|hypothetical-protein
MNGVLGVSAGAGFVRLVWAHGTGSVGSPGDRQSIVVDARGSEELTAEAVGVAVAAAEESGTAVSVGIAYGDEAQAAALDAALRRQGVAHFTLIPELDAVLAALPHDPRLAGARTVAIYDLGSSGLTVSVVDRSSGTVLASERSTAVRGDRLVRVPRETPGGLHGADAAIAESAELVGELVEQSGAVPQAVVLVGGGAHAPEVRAVLQQHSAVPVLVAPDPAFTAAVGAAELAQPPRAGRPVPASVSQRRLRSAGLAAATLVLLALIGIVSGFGRTFFGSEAGAATETPGSTLTTLVPPPSHLAPPLGEPSAVTEPDRPRL
>NZ_CP039432.1|WP_137799814.1|3398622_3399147_+|low-molecular-weight-phosphatase-family-protein
MNLVFVCTGNICRSPTAERLAAAWAADNGVDELTATSAGTRAMIGSPMEPLAAKVLSSLGGTPDGFAGRQLTPVIAGKADLILTMTQKHRDKVLRMAPRQLRRTFTLLEAAHLVTTGGARSVAELDAARATAGDLPEAGIDIRDPIGRDVVVFEQVGEQIADALVSVLDGLYRA
>NZ_CP039432.1|WP_137799815.1|3399263_3400724_-|polysaccharide-biosynthesis-tyrosine-autokinase
MEVQDYLRILQQRWRIIALATVVGVLGALVASLLSTPMYQASTRLFVSTSSAASVNEVYQGNLFSQQRVASYTKLLTGTTLAERTINRLGLTDVSAADIAAKVKATSAPDTVLIDASVEDSSPERARDIVNALSDEFVLMAAELETFDPNRPPTARVVVEQHASTPSSPVSPKTKRNLALGFAVGLLAGLGLAVLRDRLDNTIKSRQVLDELVGVGVVGMVPFDKEREQKAAIAFQDGYSGSAEAFRELRTNLQFLEVDNPPRVIAVTSSLPAEGKTTTAINLSLALAEAGYTVALVEGDLRRPRISRYLGLVDSVGVSTVLSGQADLDDVLQATSFPNLTVLAAGTIPPNPSELLGSSHATDLFTDLKARFDFVVVDASPLLPVTDAAVIAAKVDGALVAVRYGKTKREQVARAVGNLHSAGATVLGTILTMTPIKGEGAYEYKYYYDSDAPAPKSGSTPVVSSPDPRADNASGPGQNRRSETVR
>NZ_CP039432.1|WP_137799816.1|3400779_3419562_-|non-ribosomal-peptide-synthetase
MRPFSLSPAQRALLLAQQLTPDVPLMVALYVELRGPVDRALLLSACDRAARELESTVVVLVEEDGETRQVAVPDIDDAPRFLDLGDETDPESAAARWMTEQHTRPLDPTRDRLAGITLVRLSDDRHYLYCYAHHLVIDGYGAMVLVQRMAETYTAWQRGTELAPSRAVPLHELAAQDDRYTGSNREALDRAHWQPRLAALPAAISLADRPGPLAVPSRRVARTLDPATEADVPVVTAAFAAYLARAAGVREVSLSLPVAARTTAAARRTSGTLSNVVPLVVRVHPDDTVDALIERVQVELTGALRHQRYRYHAMLADLPDGDGRGSVGGVFGPVVNVMSFARELHFGDVVGEMTVLSTGPVDDLSLTVYPGSAGGALRIDFEANPTRYTDDSLRRHHHRFVEYLTAFAADRGRRVEDLPFGAADELDGLVPAVGAEAPHGPTLLPDVLTRHASSPGVALRCGDVDLTYAELDARSSALARRLIALGCGPEDGVAVLLPRSADSVLALWAVAKTGAAYVPIDPALPSHRLAQHLHGSSVAIVDPAADVALPAHLPRLDTGHDGWSTAPVTDADRVRPLRPDHPAWIVHTSGSTGRPKGVMVGHRGLAALVATLRSRYAATADARVIQLAAPIFDAALQEVLLAADAGATLVVAAPDVVSGDALADLLAVEAITHFVAAPAVLAVTAPDELSALTMLDSGGDVLPAPVAARWAPGRTLINAYGPTETTILATVSAPVDPAALDGVAAVPIGRPVDGAAVVVLDHRLRPVPPGSVGELYVAGPALARGYAGRPALTAERFVASTVGPGRMYRTGDLVRWGFDGQLEFVGRADRQVQLRGVRIELDDIEYALTEHPGIDSAAVTLVGDRLIAHVQGDVPTAGAVRDWLATRLPHHMIPDTVVVLDALPLKPSGKIDRRALATLPAPDDAAGRAPHGPVELLVADAVRAVLDIDHVDASSDFFALGGNSLSATQLVARISAGLGRQVPVRDVFMQRTVAGIAAAATARGTRPALTRTGTDDTPLAPPQQRLWLHHRAHGASSAYHVPFAVDLHGELSVPALGAVLRDVVDRHAALRTAIRDDGDGPRQVVRPVTDVVPELAVVQIDSDGDAERDAAAFAAAPFDLESGQLIRFRLQRRAADHHVLVVVAHHIAMDGLSFQPLLRDLTAAYLARCDGAPPAWESLPLQYTDYARWQHAVLRSPVSDTGGATVLDREIAYWSANLAGVADVPALPTDRPRTGAAGVPDRVPFHVDPAVRETLDRVANDLDATTFMVLHAAVAVVVAAVTGRPDTVVGAATSGRTDPALDALVGMFVGTVALRATAAPERTFGDLVAAVRGIDVEAFARAETPFEQVLDAVGLDASPLQLMLGYESFTDPDVQLPGLVLTGRELPVTQARFPLELTVREVPGAGLAGHLTYDTALFDRDTVAGWRALLHHVLATAAADPTVRIADLVAAAAPARTGRDADIATLPELAARPWRVADAHGRTVDIRPRVATLPELAARPWRVADAHGRTVDIRPRVAALAARLAAHGIGPETFVGVAVPRSVESVAAALAVAYAGAAFVPVDPGQPTARLHTILADAGVRHVIAAADVPLPPHVLRIDPNSAPDTEPGTEPAAPPRLPHPDNAAYAVFTSGSTGVPKGVVVPHRGLAPVAATLQRSFGIDADARVLHAASPAFDGSLLEYLMVLGAGATLVVAPPDTFGDDLAELIRAQSITHWFSTPAVPAQFDPAGFPALRVLGLGGEAWPADLATRWGAPETGRTALNLYGPTESTVVATVSRPLGGSGVPPIGDPVDGTTAAVLDAALRPVADGVVGELYLAGPGLARGYLGRPGHTAERFVASVLGPGRMYRTGDLVRRRGDGQLEFVARADQQVQIRGFRVEPGEVETVLAAHPAVTTAVVVADGDELAAYVHGSADLDPDDVRRHAADRLPRYMVPATVTVLETVPLSSTGKVDRAALPAPARPVPDGAALRGPLESLIGRIAADLLDLPSVGPSTDFFAFGGNSLLAARFASRLRAALGRRVDVRDVFEHPTVAALAAVLDGRAEDVGIPLVATGATGPAPLSPAQQRMWLLGRTQPSGADNIAFAVDLDGPLDVAALQAAVVDVLERHTVLRTVFPETADGPVQVVLPAAADLAPQELPADRSAAEHALASEPFDLTAQPPVRLRLYQRADRAHTLVVVAHHIAVDGLSITPLARDLDVAYRARTAGQAPEWDAPVVPFTDYARWHRAVLGDPDEPGSRAHRDLAHWRSTLAGAASTPALPTDRPRTATTEPAPADAATFSISADLHLAVEKVAQEYDSTPFMVLHAALAVLLAKLSGTDDVSVGTPVSGRGHQDIDNAVGMFVGTVVLRTAVRDRWTFAELLSHVRRTDLSAFSHADLPFDAVVAGLAGSRALAHHPLFQVMFSYDDVAPTALAFGDMQARGREIDTGRSRFDLEVAVRDREPGSHAAGFDGRFTYSRSLFDRQTVDRWTRWFVRILELVTDDPTLDVGCIDPVEAATSAAVTSPEPAAAHVPSLPAQVDRHVHERPDAVAVVAGEQRLTYAELGARSRALAAVLAERGVGAEDVVAIALPRSADLVAAMLAVVRTGAAYLPLDVTQPADRLTALLDEARPVCVVCRDGFTAPVPTVPIDALPAAGDAVPDAAVHPAQAAYVIYTSGSTGAPKGVVVTHANLSALLANTRESFDFGADDAWTMFHSPAFDFSVWEIWGPLTTGGRIVVVEHTEARSPADFRALLVRERVTVLNQTPTAFGQLADVDGEPADLAVRALIFGGEALDATRVRGWLDRHPQVTAVNMYGITETTVHLTRADVASNADGGNDIGVPLPGVRLYLLDRALRPVLPGVVGEIYVGGTQVARGYRGRPDLTAQRFVAAPNGDIVYRTGDRARLRGDGSLEYRGRSDDQLQLRGHRIEPGEVRTALTRQPGIAAAAVLGRDDRLVAYVVREPGSTAVDPTRLIRDLRRVLPDYLVPAVVVEVPQLPRTANGKLDVAALPAAAPADRRTGAPRGPLDDVVADAYRELLGIRGIGSDDDFFDLGGNSLLATQLAGRISALTGADVSVRDVFESAVVEDLARVVEERIGGPRPSRPLPASDGARERGPLSPAQRRLWFLYRFAPEESTHNLPFVVRLRGDIDVAALEAALGDVLARHRTLRTVYPSDESGPVQVVGPVPELDLTPIAVPATALDDYVRAFAETPFVLETEPPVRVRLYRTGARTHALVLVVHHIAADEWSLTPMVRDTADAYRSRLAGRAPQWDALPVQYVDYAAWQTDGAEDDLQAWVDTLDGLPEQSTLPHDHPRPATGTGHADTVRIRLDASQIGAVREAARRGRATTFMVLHAVLAAVLSRHNGSDDIPIGTVVAGRGDPRLDDVVGMFASTLVLRTRVAPDATFADLLAHVREQDLAAYTHARTPFETIVERLAPVRDASHHPLFQVALSMRRPTLPPLELPGLEVSAAAAPLDAMPFDLQLTVTETGDAVDLEFAYRSELYEAATVTAFASRFARFLDAAVQHPDTEVGRIDLLTSAEHRALVPARGAASTPAALWSLLAAGARLGGDGPAVTAGPDTLGYPELVARAEALATTLRAHGAVPGTTVACALPRSLHSVVAMWAIARTGAAPVMLDPAHPAPRLDGMLAASGAVLGVSSAERLGDLPPRTRWIDVESGAESVDLPEPVVRDDHPAYVVFTSGTTGVPKGIVLTARGLGALAQDLREVFAAAPASRMLALASPGFDAALLELLVAAGAGGCLVVAPENTYGGEELAGFLERERITHACMTPSALATVPARPLPDLAALMLGGERVAPELVERWAPGRRLYNGYGPAESTVFATYSQPLRPGRPATIGGPARGIEVRVLDARLHPVPTGVTGELYLAGDRIAAGYVGEPARTAERFVAGPDGNRWYRTGDLARWLDADEGRVLEFQGRNDTQVKVRGIRIEPGEIDAVLARRPDVDRAVTVVRTGASGAAVLASYVVPAAGVAALDTADLRRALTERLPSYMVPSAITAVPALPLTPNGKIDTRALPAPDAGVRARPVTGTEELVADVFAAVLGHDVGRTDDFFATGGDSLLATTLVARLRERTGVDVPLRLLFAEPTVAGLAAALADGDPAARGRGPVAGTRPARIPLSRAQNRLWALRRTGSGDSYRLHAQVELTGPLDVDALHAAVADVVARHDVLRSRVETDADGPYVVIDADRSDAFVTQVHSPAPDRHVLDVSIDHLVADGGSVGVLVHDLAVAYAARAAGAAPQWPPLPLQYPDFAVWDHTRDVPADALAHWRRELADVDAAVLPTDRDAAPGAAATVEFTIAPDTARALAEVAHTHRATEFMAAHAVLAALLARLSAHDDVTIATVVSGRRFPDLEPLVGLFLDTLVLRARVEPDMPLSGLLAQVRDFDVAAFDHASVPVEQILPLVGGRMPQVALAFQDFTPPVLRAGELEVRAREIDDTTARFDLQVTLSRAADGGLDGVLSYDTARFDAATAAGLSEQFAAALGAVATDPQLSVQELPLAVATVRGFETDTAPRPLPELLRATAAAHPDRVAVIDGAAQLTYRELDAQSDALAAQLIRDHGYGTDDVVALAPARSLDRIRMLWAVTKTGAAFGARTVRAAAAGTARTGPVDALAYVITTSGSTGTPKTVAVTHRGLAALAAEARRRYRVAAGDRVLHGYDPAFDAAVLEILLAHTSGAALVVAPPDVFAGPRLHTLLREHAVTHFLSTPAVLATVDHTGLDALRVVASGGEALAPQVADRWRRGRLMIDAYGPTEATVVATVTEVDGRPGLGDPIPGNTVRVLDDRLRPVPVGGVGELYLSGVGLARGYLGAPALTAASFVAAPDGARMYRTGDRVRVHADGRLLFLGRTDRQVKVRGVRVEPGHVEAVLARRPGVEQAAVIVWHGTLVAFVTGTEVDVPALLATVAAELPAAAVPARVVVLGALPTTANGKIDADALAVLAADSAPRTARTLTAREQQVADVVGDVLGFAVDIDASFLAAGGHSLAAVEVAARLSAALARDIAPRTVFEAPTLAALAAATTPAASSEVALAPSTDTVAPIAPAQRRLWLLHQADPTHTAYSMPIVLRLTGDVDGPALTAAFRDVVTRHEALRTIYPDADTQRVVPAADVDFELDTAGGDAFDGRIAALLVRPLELTTRPPVRGGLFRADDGGWVLVVVAHHIAFDGASVAPLLADLAVAYAARTAGTAPRWEPLALQYRDFARWQVARLGDPADPNSLGGRQLAFWQRALAGLPEAPLPLPTDRPRPARPSHRGDAVDTALPAATHAALAAFARAHDVTVFMVLHAALAALLARYSGRNDIAVGTVAAGRPDPRLQSIVGMFVGTLVLRVGVDTTEPFTGLLRRARATQLDAFAHADVPFDDVVAHVAPTRDPAFHPLFQVLLAHSAGAAPVPALPGIRIDEGSAADPAAQFDLAFDVREELGNNGIGVRLVYATDLFDRATAAQLLGDWSALLDAVVADPAAAVGDLPLAAPAPEPAPAPAPRTLATILADTVAAHPDRVALRAGSDQWTYAELDAVAAERADRLRVSGIGPGDVVPVDAVRGPDWVIDVWAVTRTGAAWVPVDPKLPDERKTLLANLSETAVARPLAASGAVDELAYVLFTSGSTGLPKGVEVTHRGLEALVDLQRRRLGITAESRVLQAASPTFDAAVFEMLAAHAHGGTLVCAPEYAYAGDDLASLLNEHAITHVNLTPTVLGTLDPAALPGPLTVVAAGEVLPVPLARAWADHHLHNGYGPTEVTVGATCSGPLSAGDVTIGVPLAGVGTAVLDARLHPVPVGVVGELYLVGSGLARGYRGQPALTAARFVAGPGGARLYRTGDLVRRRRDGALEYVGRSDDQVQIHGVRVEPGEIDAVFGAEPEVRASVTVARRGGDAEPVLVTYVQPAPGRDPDPARLRERAARLLPRHLVPAAVQVVDSLPRTESGKIDRAALPEPAVDDGSVQGTPPRTALERQIAAVVAEVTGHADVPREAGFFELGGTSMGAVRVAARLREELGRDVALEWLFTEPTVAGLARRIERGDDAADPLATLIRLNRPAAPAGPPLFCIHPVSGLAWGYAGLAEHLGDRPLYGLQATGGAPTGTITDLAREYVAQIRAVQPDGPYHLLGWSLGGNVAHEMAVQLEAAGTDVASLVLLDSHPSDLVPAGTGAAWDDHADERLDSDLGALASSEIRRVLEIGEKLEAAASVHRPGTHRGDALVFIAAHEDEVRRRNVSGWSRIVSGRVTTIEVPCRHSDMIEPDALARIASVLVDSTGEIV
>NZ_CP039432.1|WP_137799817.1|3419718_3421626_+|DUF4012-domain-containing-protein
MRFRLRCRTHHDKRGIRLVAHLDSDGSATTEDAGTTRVRTRRRRTVQPAVTRKKRRRIVIGVSCAVVAVAAWGGYMAYEAMQVKANLERARDFAMTTKDSLLAGNSDQATLSASDAAKYAERAQNSTESISWRVAAAVPGLGGPFDTTRQITDVVRGLTDDVLGPAVQAGSVVSPDRLIRDGGRIDLEPLRQASPALAESAGAAAALADRAGGVDSTFLGVIDDARTQLQEQTADLSRLLGNVSTASQIVPPMMGADGPRSYFVGFQTNAEARGTGGLLGGFGEFRAVDGTVRVDDLASNRELPVKDKKPIDLGPDFEKTYGISRPTTDFRNSNVSSHFPYAAQIWRSLWAQESGEQVDGVIATDPVALSYILAVVGPVTMPDGEKITADNVVELTESTAYARFANDDKARKAYLQAIAGKVIERMTGKISNPKALLEALGRAASERRIAVWSANPAEQQVIEGTVLGHTVPDDPAPYAGVVVNNLGGNKLDYYLQREIDYTAESCAGDTRRSTVTVRLTNALPAGDYTKYVAGMFDNPMGAPMGTNLTNLSLVATQGAKLDKVTVDGKPAFAFTGAERGHPVFDIQTQIRREQTIEVKYELTEPTVAGEPRMPVQALVDSANVRVEVPACGPAD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

284675 : 292424

Corynebacterium_phage(33.33%)

tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_137797278.1\|284675_285338_+	hypothetical protein	S5Y4U6	Mycobacterium_phage	2.3e-27	31.9
WP_137797279.1\|285676_286009_+	hypothetical protein	NA	NA	NA	NA
WP_137797280.1\|286047_286494_+	hypothetical protein	NA	NA	NA	NA
WP_137797281.1\|286490_286880_+	hypothetical protein	NA	NA	NA	NA
WP_137797282.1\|286907_287306_+	hypothetical protein	A0A1P8VVI0	Erythrobacter_phage	8.4e-09	42.5
WP_137797283.1\|287358_288240_+\|tail	phage tail protein	A0A220NQR1	Corynebacterium_phage	6.1e-52	37.5
WP_137797284.1\|288236_289925_+\|tail	phage tail protein	A0A220NQQ5	Corynebacterium_phage	1.2e-144	45.5
WP_137797285.1\|289966_290398_+	DUF2744 domain-containing protein	A0A166Y257	Gordonia_phage	2.2e-15	40.2
WP_137797286.1\|290751_291072_+	hypothetical protein	NA	NA	NA	NA
WP_137797287.1\|291068_292424_+	hypothetical protein	G9FHL2	Rhodococcus_virus	1.3e-13	25.2

DBSCAN-SWA_2

2379659 : 2394119

Gordonia_phage(75.0%)

capsid,integrase,terminase,portal

attL 2377426:2377441|attR 2381851:2381866

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2377426:2377441	attL	NA	NA	NA	NA
WP_137799005.1\|2379659_2380592_-\|integrase	tyrosine-type recombinase/integrase	A0A2K9VH72	Gordonia_phage	5.1e-65	46.8
WP_137799006.1\|2380742_2381108_-	hypothetical protein	A0A142KB63	Gordonia_phage	1.6e-30	57.4
WP_137799007.1\|2381104_2381617_-	ImmA/IrrE family metallo-endopeptidase	A0A142KB62	Gordonia_phage	9.0e-72	81.8
WP_137799008.1\|2382054_2382924_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
2381851:2381866	attR	NA	NA	NA	NA
WP_137799009.1\|2382920_2384351_-	hypothetical protein	A0A142K9S3	Gordonia_phage	3.1e-05	57.1
WP_137799010.1\|2384448_2385054_-	hypothetical protein	A0A1C9EHX3	Gordonia_phage	4.2e-36	43.5
WP_137799011.1\|2385154_2385628_-	hypothetical protein	NA	NA	NA	NA
WP_137799012.1\|2385624_2385927_-	HK97 gp10 family phage protein	A0A1C9EHV8	Gordonia_phage	1.8e-16	45.1
WP_137799013.1\|2385926_2386223_-	hypothetical protein	NA	NA	NA	NA
WP_137799014.1\|2386225_2386600_-	hypothetical protein	NA	NA	NA	NA
WP_137799015.1\|2386596_2386998_-	hypothetical protein	NA	NA	NA	NA
WP_137799016.1\|2386975_2387374_-	hypothetical protein	NA	NA	NA	NA
WP_137799017.1\|2387373_2388378_-\|capsid	phage capsid protein	G9FH86	Rhodococcus_phage	6.2e-141	77.6
WP_137799018.1\|2388430_2388685_-	hypothetical protein	NA	NA	NA	NA
WP_137799019.1\|2389056_2390058_-	hypothetical protein	A0A1C9EHV4	Gordonia_phage	1.2e-75	47.6
WP_137801159.1\|2390035_2391370_-\|portal	phage portal protein	A0A2H4JAT8	uncultured_Caudovirales_phage	6.6e-66	34.2
WP_137799020.1\|2392059_2393097_-\|terminase	terminase	A0A1C9EHW4	Gordonia_phage	2.0e-142	67.3
WP_137799021.1\|2393086_2393575_-	hypothetical protein	A0A1C9EHY3	Gordonia_phage	3.5e-33	58.4
WP_137801160.1\|2393834_2394119_-	hypothetical protein	A0A2P1JXV5	Rhodococcus_phage	2.4e-18	49.5

DBSCAN-SWA_3

4060323 : 4067769

Planktothrix_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_137800315.1\|4060323_4061079_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-34	37.6
WP_137800316.1\|4061105_4061699_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_137800317.1\|4061935_4062925_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	2.2e-74	51.5
WP_137800318.1\|4062921_4063299_+	thioredoxin	A0A1J0GW78	Streptomyces_phage	2.1e-25	55.1
WP_137800319.1\|4063457_4064660_+	N-acetylmuramoyl-L-alanine amidase	U5PWQ2	Bacillus_phage	5.3e-06	27.8
WP_137800320.1\|4064720_4065413_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_137800321.1\|4065650_4066760_-	ParB/RepB/Spo0J family partition protein	S5VTK0	Leptospira_phage	6.2e-09	32.6
WP_137800322.1\|4066761_4067769_-	ParA family protein	Q8JL10	Natrialba_phage	4.0e-23	32.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP039432

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection