| NZ_CP027295.1|WP_137771402.1|3191849_3193016_-|ADP-forming-succinate--CoA-ligase-subunit-beta |
gnl|CDD|234813 |
PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.
|
0 |
| NZ_CP027295.1|WP_137771397.1|3187080_3187926_+|HAD-hydrolase-family-protein |
gnl|CDD|319819 |
cd07517, HAD_HPP, phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily. Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
|
2.4101e-28 |
| NZ_CP027295.1|WP_137771390.1|3178583_3179963_-|formimidoylglutamate-deiminase |
gnl|CDD|236420 |
PRK09229, PRK09229, N-formimino-L-glutamate deiminase; Validated.
|
2.42912e-167 |
| NZ_CP027295.1|WP_137771394.1|3183725_3185180_-|alcohol-acetyltransferase |
gnl|CDD|380464 |
cd19542, CT_NRPS-like, Terminal Condensation (CT)-like domains of nonribosomal peptide synthetases (NRPSs). Unlike bacterial NRPS, which typically have specialized terminal thioesterase (TE) domains to cyclize peptide products, many fungal NRPSs employ a terminal condensation-like (CT) domain to produce macrocyclic peptidyl products (e.g. cyclosporine and echinocandin). Domains in this subfamily (which includes both terminal and non-terminal domains) typically have a non-canonical conserved [SN]HxxxDx(14)Y motif at their active site compared to the standard Condensation (C) domain active site motif (HHxxxD). C-domains of NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain.
|
0.000981251 |
| NZ_CP027295.1|WP_137771401.1|3190949_3191840_-|succinate--CoA-ligase-subunit-alpha |
gnl|CDD|180194 |
PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.
|
0 |
| NZ_CP027295.1|WP_137771389.1|3177327_3178587_-|imidazolonepropionase |
gnl|CDD|237604 |
PRK14085, PRK14085, imidazolonepropionase; Provisional.
|
0 |
| NZ_CP027295.1|WP_137771405.1|3193975_3196750_-|UvrD-helicase-domain-containing-protein |
gnl|CDD|273429 |
TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].
|
0 |
| NZ_CP027295.1|WP_137771408.1|3198876_3199914_-|alpha/beta-hydrolase |
gnl|CDD|225176 |
COG2267, PldB, Lysophospholipase [Lipid metabolism].
|
3.01836e-33 |
| NZ_CP027295.1|WP_137771396.1|3186188_3186962_-|IclR-family-transcriptional-regulator |
gnl|CDD|224332 |
COG1414, IclR, Transcriptional regulator [Transcription].
|
7.91217e-46 |
| NZ_CP027295.1|WP_137771391.1|3179959_3181165_-|allantoate-amidohydrolase |
gnl|CDD|236456 |
PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.
|
2.46984e-150 |
| NZ_CP027295.1|WP_137771400.1|3190073_3190805_-|metal-dependent-transcriptional-regulator |
gnl|CDD|224240 |
COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].
|
2.19055e-39 |
| NZ_CP027295.1|WP_137771392.1|3181170_3182928_-|urocanate-hydratase |
gnl|CDD|235448 |
PRK05414, PRK05414, urocanate hydratase; Provisional.
|
0 |
| NZ_CP027295.1|WP_137771395.1|3185176_3186163_-|alpha/beta-hydrolase |
gnl|CDD|369561 |
pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.
|
1.6609e-71 |
| NZ_CP027295.1|WP_137771406.1|3197220_3198387_+|flippase-like-domain-containing-protein |
gnl|CDD|129470 |
TIGR00374, UPF0104_membrane_protein_MTH_1261, conserved hypothetical protein. This model is built on a superfamily of proteins in the Archaea and in Aquifex aeolicus. The authenticity of homology can be seen in the presence of motifs in the alignment that include residues relatively rare among these sequences, even though the alignment includes long regions of low-complexity hydrophobic sequences. One apparent fusion protein contains a Glycos_transf_2 region in the N-terminal half of the protein and a region homologous to this superfamily in the C-terminal region. [Unknown function, General].
|
5.63615e-09 |
