CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP040230	Staphylococcus aureus strain GD1108 chromosome, complete genome	13 crisprs	cas3,DEDDh,DinG,csa3,TnsE_C,WYL	4	2	10	3

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP040230_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_1

614895-615003

Orphan

Consensus_repeat	Method
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_1

>merge|NZ_CP040230|1|614895-615003|CRISPRCasFinder
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAAAGCCTCTAATCACTAGAGTTCAAGAGGCTTTAAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA

>NZ_CP040230|1|1|614895-615003|CRISPRCasFinder
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA	AGCCTCTAATCACTAGAGTTCAAGAGGCTTT
AAAGGAACGCAGTTGGATGCTACCGCACAACTGCATAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000808883.1\|605295_606234_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381309
NZ_CP040230.1\|WP_016187114.1\|615114_615942_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NZ_CP040230.1\|WP_072434949.1\|611563_611947_+\|DUF1934-family-protein	unknown	unknown	gnl\|CDD\|226896
NZ_CP040230.1\|WP_000362963.1\|617800_618601_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP040230.1\|WP_000633790.1\|606679_607216_+\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP040230.1\|WP_000901759.1\|614089_614725_+\|endonuclease-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|225140
NZ_CP040230.1\|WP_138742442.1\|620289_621078_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP040230.1\|WP_138742441.1\|611943_613605_+\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NZ_CP040230.1\|WP_000365352.1\|617097_617817_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NZ_CP040230.1\|WP_000735556.1\|618736_619243_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000169038.1\|623773_623998_-\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NZ_CP040230.1\|WP_016187113.1\|609224_609746_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378039
NZ_CP040230.1\|WP_001807864.1\|622651_623581_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|225778
NZ_CP040230.1\|WP_001222139.1\|619404_620121_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001826156.1\|606257_606449_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001018677.1\|621329_621704_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944
NZ_CP040230.1\|WP_001200750.1\|610244_611255_+\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|181842
NZ_CP040230.1\|WP_000477504.1\|607385_607862_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP040230.1\|WP_010922824.1\|616092_617043_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP040230.1\|WP_000180233.1\|607901_609197_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000808883.1\|605295_606234_+\|aldo/keto-reductase	gnl\|CDD\|381309	cd19083, AKR_AKR11A1_11D1, AKR11A and AKR11D families of aldo-keto reductase (AKR). Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).	1.23356e-168
NZ_CP040230.1\|WP_016187114.1\|615114_615942_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.69801e-72
NZ_CP040230.1\|WP_072434949.1\|611563_611947_+\|DUF1934-family-protein	gnl\|CDD\|226896	COG4506, COG4506, Uncharacterized protein conserved in bacteria [Function unknown].	9.66881e-54
NZ_CP040230.1\|WP_000362963.1\|617800_618601_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.7852e-26
NZ_CP040230.1\|WP_000633790.1\|606679_607216_+\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.37974e-25
NZ_CP040230.1\|WP_000901759.1\|614089_614725_+\|endonuclease-III-domain-containing-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	5.92839e-91
NZ_CP040230.1\|WP_138742442.1\|620289_621078_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.38459e-33
NZ_CP040230.1\|WP_138742441.1\|611943_613605_+\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NZ_CP040230.1\|WP_000365352.1\|617097_617817_+\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	5.71997e-38
NZ_CP040230.1\|WP_000169038.1\|623773_623998_-\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	3.83351e-14
NZ_CP040230.1\|WP_016187113.1\|609224_609746_+\|hypothetical-protein	gnl\|CDD\|378039	pfam08741, YwhD, YwhD family. This family of proteins are currently uncharacterized. They are around 170 amino acids in length.	5.69328e-97
NZ_CP040230.1\|WP_001807864.1\|622651_623581_-\|DMT-family-transporter	gnl\|CDD\|225778	COG3238, COG3238, Uncharacterized protein conserved in bacteria [Function unknown].	6.93341e-34
NZ_CP040230.1\|WP_001018677.1\|621329_621704_-\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.77309e-26
NZ_CP040230.1\|WP_001200750.1\|610244_611255_+\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|181842	PRK09422, PRK09422, ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional.	0
NZ_CP040230.1\|WP_000477504.1\|607385_607862_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.13315e-11
NZ_CP040230.1\|WP_010922824.1\|616092_617043_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	6.43614e-48
NZ_CP040230.1\|WP_000180233.1\|607901_609197_+\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	3.99954e-151

>NZ_CP040230.1|WP_000901759.1|614089_614725_+|endonuclease-III-domain-containing-protein
MLGTDELYKLLYRHMGPQNWWPADNDIEMMLGAILVQNTRWRNAEIALNQIKEHTHFNPNHILELPIETLQSLIRPSGFYKSKSLTIKTLLTWLARHHFNYQEINERYKAELRKELLTLKGIGSETADVLLVYIFERIEFIPDSYTRKIYNKLGYENTKSYDQLKKVITLPNHFTNQDANEFHALLDVFGKHYFRDKDIKNYDFLEPYFKK
>NZ_CP040230.1|WP_138742441.1|611943_613605_+|arginine--tRNA-ligase
MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNILLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVNSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVAAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIVKTKAHVAMIEAVRITLKNALAMVGVSAPESM
>NZ_CP040230.1|WP_072434949.1|611563_611947_+|DUF1934-family-protein
MLKQHNEKEKFEFTTEGTWQQRQSNFIRYVEQIEDATVNVTIKVDDDSVKLIRKGDINMNLHFVEGQATTTFYDISAGRIPLEVKTLRILHFVSGDGGKLKIHYELYQDNEKMGSYQYEINYKEIGE
>NZ_CP040230.1|WP_001200750.1|610244_611255_+|alcohol-dehydrogenase-AdhP
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADVIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
>NZ_CP040230.1|WP_016187113.1|609224_609746_+|hypothetical-protein
MEVISLSEKKGFNFNIIKNDPLDGHKGTNIGSISLDNIAPVFIDVANKEAFIDIGGMHARAKVEKGVKWITDKAAVEGDEAKEYWLCWVTTERNEQGPYYAGLTACYLLVNKAIRRGYKSMPEHVNMMDKSMKHHIIIDQIGDENKVILKDFLMNHDEGMWKHSSDALHQAFN
>NZ_CP040230.1|WP_000180233.1|607901_609197_+|HD-domain-containing-protein
MTNAYVDLKLVEEKVFKDPIHRYIHVEDQLIWDLIKTKEFQRLRRIRQLGTLYLSFHTAEHSRFGHSLGVYEIVRRLIDESFIGHDAWDNKDRPLALCAALLHDLGHGPFSHSFEKIFNTDHEAYTQAIITGDTEVNAVLRKVSPEFPREVAEVINKTHHNKLVISMISSQIDADRMDYLQRDAYFTGVSYGAFDMERILRLMRPSKDEVLIKESGMHAVENFIMSRYQMYWQIYFHPVSRGGEVLLNNCLKRAKQLYNEGYEFKLHPHDFIPFFEETVTIEQYVELDEAVVTYYLEKWTKEDDAILSDLASRFINRDLFKYIPFDGSIITISELQELFEAGGINPDYYFVSEAFSDLPYDYDRPGSNRKPIHLLRQDGKIREISNQSLVIHSITGINRQDYKLYYPREMVAKIKDKTIREAIENLINELN
>NZ_CP040230.1|WP_000477504.1|607385_607862_+|GNAT-family-N-acetyltransferase
MFKVRQATEKDVVQIRDVATKAWFNTYLNIYAATTVNHLLEASYNEHHLKKRLQEQLFLVVEEGNDIVGFANFIYGEELYLSAHYVKPESQHTGYGTALLNEGLSRFEDKFEGVYLEVDNKNEEAVAYYKEQGFTILRSYEPEMYGEKLDLALMYKAF
>NZ_CP040230.1|WP_000633790.1|606679_607216_+|flavodoxin-family-protein
MITVLFGGSRPNGNTAQLTKFALQGLDYQWIDVTQHRFKPIRDVRHIEESITDYEDDYQEILDKVLASDTIIFASPVYWYSISAPLKAFIEHWSETLQDKRYPNFKAQMAEKDFRVILVGGDCPKIKAKPAITQMKYSLDFLGATLNGYIIGTANKPGDIMKDNYALARATEWNQLLQ
>NZ_CP040230.1|WP_001826156.1|606257_606449_-|hypothetical-protein
MGIQFLFVGAHPQLALPVEFLFEILCVGPLTRIEKSLLQAHFRSVNYCQYNFVEHRTLIYVPA
>NZ_CP040230.1|WP_000808883.1|605295_606234_+|aldo/keto-reductase
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINFLDTAYIYGPERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDDNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEENVRRVNALEKIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVIENIKAADIVLSKDEIQYIDELFPIED
>NZ_CP040230.1|WP_016187114.1|615114_615942_+|ABC-transporter-substrate-binding-protein
MKDNDKQSSDDNGSSKSPYHRIVSLMPSNTEILYELGLGKYIVGVSTVDDYPKDVKKGKKQFDALNLNKEELLKAKPDLILAHESQKATANKVLSSLEKQGIKVVYVKDAQSIDETYNTFKQIGKLTHHDKQAEQLVEETKDNIDKVIDSIPAHHKKSKVFIEVSSKPEIYTAGKHTFFNDMLEKLEAQNVYSDINGWNPVTKESIIKKNPDILISTEAKTRSDYMDIIKKRGGFNKINAVKNTRIEVVNGDEVSRPGPRIDEGLKELRDAIYRK
>NZ_CP040230.1|WP_010922824.1|616092_617043_+|iron-ABC-transporter-permease
MTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVIGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH
>NZ_CP040230.1|WP_000365352.1|617097_617817_+|HAD-family-hydrolase
MDLNQIKAVVFDLEGTLLDRVKSREKFIEEQYERFHDYLIHVQLADFKKAFIELDDDEDNDKPDLYKEIIKRFHVDRLTWKDLFNDFEMHFYRYVFPYYDTLYTLEKLSQKGFQIGVIANGKSKIKQFRLHSLGLMHVINYLSTSETVGFRKPHPKIFEDMIDQLGVLPEQIMYVGDDALNDVAPARAMGMVSVWYKQEDAEIEPLEEEVDFTITTVEELLTILPIKIDNKGENYGSIY
>NZ_CP040230.1|WP_000362963.1|617800_618601_+|alpha/beta-hydrolase
MDLFTRKDGTSIHYSTLGEGYPIVLIHTVLDNYSVFNKLAAELAKSFQVVLIDLRGHGYSDKPRHIEIKDFSDDIVELLKYLYIEEVAFVCHEMGGIIGADISVRYPEFTSSLMLVNPTSIEGELPEERLFRKYAHIIRNWDPEKQDKFLNKRKYYRPRKMNRFLKHVVDTNEISTKEEIQAVKEVFKNADISQTYRNVVVPTKIIAGEFGERTTRLEAKEVADLIQNADFEVYQESSAFPFVEEQERFVEDTAAFINKHHDEKHV
>NZ_CP040230.1|WP_000735556.1|618736_619243_+|hypothetical-protein
MKKLLTASIIACSVVMGVGLANTSAEAASGNSIDTVKQLIKGDQSLENVKIGESIKDVLTKYKNPMYSYNENGTEHYYEFHTKKGMLLVTTDGKKNNGKVTHISMMYNDANGPTYQAVKNYVGKAVTHTEYSKVAGNFGYIEKGKTTYQFASAPKDKNIKLYRIDLEK
>NZ_CP040230.1|WP_001222139.1|619404_620121_+|hypothetical-protein
MRINDKILLENIEDYFNHKGLSPHLIDDIKEKVITDIKNSEKKDQDYIEYKRKSPAQIILMIQRNLFALQMNPVIFFILNFILISYLYDKQYVQFQAITGMSLFYCLVIFPMTIVVYLRVSQKNYLRSNKIEMIMGTIIAIISLLLIILQAFNITWGVIPITNFGHQFFFFIGIILVIAGIFYKRLEFSGIGLLFCQKTLDAMIHNPQSAQTFSLIIWILLVVLVIYFTIRLSSRTRL
>NZ_CP040230.1|WP_138742442.1|620289_621078_+|alpha/beta-fold-hydrolase
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYVYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLESHFLNVTKKIFEHSGHAPHIEEPEAFLSYYLNFLKSVS
>NZ_CP040230.1|WP_001018677.1|621329_621704_-|transcriptional-regulator
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
>NZ_CP040230.1|WP_001807864.1|622651_623581_-|DMT-family-transporter
MLLFYIIGVIVGMFIPIQTSVNSRLSLYTKSPFYTSFISFSVGTICLIVLNIFINPDVFSLHFFSNQTFNYTWFVGGLLGVGYLTGNLLLLPKLGATLTVIATVAGQIIMGVIIDTFGLFGATIHDFNLIKAIGVLLLIVGIITMNQINKCNLLLTNQKHLIFWLLLGFTFGFFPPIQTTINSLLASHTHSPAFASLVSFTIGSITLLILTAIFNRSLKLKTSHLKFGKLKPIYFTGGILGMAFVTANIILMPHMGAALTTLIGMFGQILMGILIDHFGLFGSPKIAMTSRKTIGLLCILTGIILLRLF
>NZ_CP040230.1|WP_000169038.1|623773_623998_-|DUF2922-domain-containing-protein
MTKTLELSFKSSLDKPVKLQLPQLNNIVTEQVARDSMNALVDLNILKSNSGAITKVHSAQIIDKTTTVLFEAKK

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP040230_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_2

778199-778281

Orphan

Consensus_repeat	Method
CACCCCAACTCGCATTGCTTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_2

>merge|NZ_CP040230|2|778199-778281|CRISPRCasFinder
CACCCCAACTCGCATTGCTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCACCCCAACTCGCATTGCCTGTAGAA

>NZ_CP040230|2|2|778199-778281|CRISPRCasFinder
CACCCCAACTCGCATTGCTTGTAGAA	TTTCTTTTCGAAATTCTCTGTGTTGGGGCCC
CACCCCAACTCGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000675901.1\|782844_784479_+\|NAD-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|237414
NZ_CP040230.1\|WP_001224800.1\|774847_775333_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP040230.1\|WP_000538141.1\|766461_767112_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NZ_CP040230.1\|WP_000816293.1\|784685_785588_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NZ_CP040230.1\|WP_000229253.1\|767613_769599_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP040230.1\|WP_001248939.1\|779457_780453_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_CP040230.1\|WP_000958224.1\|773062_773995_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP040230.1\|WP_000638419.1\|767108_767345_+\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NZ_CP040230.1\|WP_000057561.1\|775340_776780_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP040230.1\|WP_000006551.1\|780561_781506_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP040230.1\|WP_000279414.1\|788760_789771_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NZ_CP040230.1\|WP_000134958.1\|776846_777782_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP040230.1\|WP_001049165.1\|782074_782662_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_CP040230.1\|WP_000654030.1\|787694_788708_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP040230.1\|WP_000070836.1\|786290_786920_+\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NZ_CP040230.1\|WP_000662684.1\|769606_772453_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP040230.1\|WP_000513301.1\|774000_774840_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP040230.1\|WP_071938136.1\|772482_772713_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000369722.1\|778549_779461_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NZ_CP040230.1\|WP_001074744.1\|789909_791100_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000675901.1\|782844_784479_+\|NAD-dependent-malic-enzyme	gnl\|CDD\|237414	PRK13529, PRK13529, oxaloacetate-decarboxylating malate dehydrogenase.	0
NZ_CP040230.1\|WP_001224800.1\|774847_775333_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.7022e-30
NZ_CP040230.1\|WP_000538141.1\|766461_767112_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NZ_CP040230.1\|WP_000070836.1\|786290_786920_+\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	7.04966e-05
NZ_CP040230.1\|WP_000229253.1\|767613_769599_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP040230.1\|WP_001248939.1\|779457_780453_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NZ_CP040230.1\|WP_000958224.1\|773062_773995_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NZ_CP040230.1\|WP_000638419.1\|767108_767345_+\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NZ_CP040230.1\|WP_000057561.1\|775340_776780_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	7.86204e-06
NZ_CP040230.1\|WP_000006551.1\|780561_781506_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NZ_CP040230.1\|WP_000279414.1\|788760_789771_+\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP040230.1\|WP_000134958.1\|776846_777782_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	1.80771e-153
NZ_CP040230.1\|WP_000816293.1\|784685_785588_-\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.98978e-153
NZ_CP040230.1\|WP_000654030.1\|787694_788708_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
NZ_CP040230.1\|WP_000662684.1\|769606_772453_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP040230.1\|WP_000513301.1\|774000_774840_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	4.21225e-120
NZ_CP040230.1\|WP_001049165.1\|782074_782662_+\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NZ_CP040230.1\|WP_000369722.1\|778549_779461_+\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NZ_CP040230.1\|WP_001074744.1\|789909_791100_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0

>NZ_CP040230.1|WP_000134958.1|776846_777782_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIETKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NZ_CP040230.1|WP_000057561.1|775340_776780_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMANQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVIENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP040230.1|WP_001224800.1|774847_775333_+|acetyltransferase
MRKFLSKTYHHTNPLWHVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP040230.1|WP_000513301.1|774000_774840_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPGEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NZ_CP040230.1|WP_000958224.1|773062_773995_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NZ_CP040230.1|WP_071938136.1|772482_772713_-|hypothetical-protein
MYEFYSCIPIFKYTIAVANDKEPIHNKSLVILYHFCPAPSFDLCLATLDRSYLNIILFTHLFFLLFITKLIKRSEG
>NZ_CP040230.1|WP_000662684.1|769606_772453_+|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNINLSEQDQAIANQILKEIISRLAFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKINRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDN
>NZ_CP040230.1|WP_000229253.1|767613_769599_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NZ_CP040230.1|WP_000638419.1|767108_767345_+|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NZ_CP040230.1|WP_000538141.1|766461_767112_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NZ_CP040230.1|WP_000369722.1|778549_779461_+|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NZ_CP040230.1|WP_001248939.1|779457_780453_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NZ_CP040230.1|WP_000006551.1|780561_781506_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NZ_CP040230.1|WP_001049165.1|782074_782662_+|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NZ_CP040230.1|WP_000675901.1|782844_784479_+|NAD-dependent-malic-enzyme
MKGIELLNNPFLNKGIAFTNEERKQLGLEGLLPANVRTLEQQAEQCYEQFKAKQTDFEKRLFLMAIFNRNRTLFYKLTSEHLVEFMPIIYDPVIAQSIEQYNENFSRPQDAVFLSVDRQDQIEQELRNVANGRDIRLIVVTDAEGILGIGDWGVDGVDIAIGKLIVYTAAAGINPSQVLPVSLDVGTNNEQLLNDDLYLGNRHKRVDDETYYAFVDKFVSAVRKEYPNALLHWEDFGRGHAKNILDKYEDTLPTFNDDIQGTGIVTLAGVLGALNISKVNYTNQTFLVYGGGTAGMGITNILKDELIKQGVSEEKANQHFYIMDKQGLLFDDMDDLTEAQQVFAKNRNEFSKTVNWKNLKEVIENIKPTVLIGTSTQTGAFTEDAVKEMLKHTERPMIFPLSNPTKLAEATAQDLLKWTNGKALIGTGIPYNDIEYNGVNYSIGQANNALMYPGLGLGLIASKAKKVNQQILSAASHALGGMVNPDEPGAAVLPPVEKIHQCSRAIAKAVAQSVIDQGLNAETIDDIDKAIEAEIWYPEYKSYI
>NZ_CP040230.1|WP_000816293.1|784685_785588_-|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQKIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGIILSNEGGALQTMKLPYEYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLISK
>NZ_CP040230.1|WP_000070836.1|786290_786920_+|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQNQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>NZ_CP040230.1|WP_000654030.1|787694_788708_+|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>NZ_CP040230.1|WP_000279414.1|788760_789771_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>NZ_CP040230.1|WP_001074744.1|789909_791100_+|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPDLGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK

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Crispr_ID: NZ_CP040230_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_3

871188-871268

Orphan

Consensus_repeat	Method
TCTTTATCATTTCTGTCCCACTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_3

>merge|NZ_CP040230|3|871188-871268|CRISPRCasFinder
TCTTTATCATTTCTGTCCCACTCCCAAGAACCAATACATAATAAAGCATAAGTGATTCTTTATCATTTCTCTCCCACTCCC

>NZ_CP040230|3|3|871188-871268|CRISPRCasFinder
TCTTTATCATTTCTGTCCCACTCCC	AAGAACCAATACATAATAAAGCATAAGTGAT
TCTTTATCATTTCTCTCCCACTCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000752917.1\|871410_871605_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
NZ_CP040230.1\|WP_138742458.1\|873877_875185_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_CP040230.1\|WP_000732338.1\|869781_870603_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP040230.1\|WP_000571213.1\|868050_869076_+\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NZ_CP040230.1\|WP_000168845.1\|873017_873779_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_CP040230.1\|WP_000274033.1\|878874_879189_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000267231.1\|880611_881679_+\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|224981
NZ_CP040230.1\|WP_000662306.1\|865430_865544_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000520233.1\|869068_869764_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP040230.1\|WP_001065802.1\|867504_867801_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP040230.1\|WP_001018957.1\|867125_867512_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224572
NZ_CP040230.1\|WP_000290492.1\|864985_865366_+\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NZ_CP040230.1\|WP_000589549.1\|864471_864828_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NZ_CP040230.1\|WP_001074405.1\|877145_878543_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_CP040230.1\|WP_001183849.1\|871838_872690_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
NZ_CP040230.1\|WP_000807673.1\|875299_876541_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_CP040230.1\|WP_000582322.1\|879557_880598_+\|DUF21-domain-containing-protein	unknown	unknown	gnl\|CDD\|226911
NZ_CP040230.1\|WP_001010508.1\|876530_876995_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NZ_CP040230.1\|WP_000932205.1\|865545_866424_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NZ_CP040230.1\|WP_138742457.1\|870761_870983_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000752917.1\|871410_871605_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07
NZ_CP040230.1\|WP_138742458.1\|873877_875185_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	6.62916e-135
NZ_CP040230.1\|WP_000732338.1\|869781_870603_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	5.3847e-113
NZ_CP040230.1\|WP_001183849.1\|871838_872690_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	2.68358e-76
NZ_CP040230.1\|WP_000168845.1\|873017_873779_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
NZ_CP040230.1\|WP_000589549.1\|864471_864828_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NZ_CP040230.1\|WP_000267231.1\|880611_881679_+\|nitronate-monooxygenase	gnl\|CDD\|224981	COG2070, COG2070, Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only].	2.6112e-111
NZ_CP040230.1\|WP_000520233.1\|869068_869764_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	9.67625e-100
NZ_CP040230.1\|WP_001065802.1\|867504_867801_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.92494e-14
NZ_CP040230.1\|WP_001018957.1\|867125_867512_+\|hypothetical-protein	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	4.21303e-36
NZ_CP040230.1\|WP_000290492.1\|864985_865366_+\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	1.19798e-69
NZ_CP040230.1\|WP_000932205.1\|865545_866424_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	1.16986e-75
NZ_CP040230.1\|WP_001074405.1\|877145_878543_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP040230.1\|WP_000807673.1\|875299_876541_+\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP040230.1\|WP_000582322.1\|879557_880598_+\|DUF21-domain-containing-protein	gnl\|CDD\|226911	COG4536, CorB, Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism].	2.87954e-160
NZ_CP040230.1\|WP_001010508.1\|876530_876995_+\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	6.42482e-68
NZ_CP040230.1\|WP_000571213.1\|868050_869076_+\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	2.03316e-170

>NZ_CP040230.1|WP_138742457.1|870761_870983_-|hypothetical-protein
MYTGFPSASMLGPTPTCTVYKISFRNPLCWGPAIIVKRLLQSYFHSINNCLYNIVNLWTLIEITEAYRPSLYI
>NZ_CP040230.1|WP_000732338.1|869781_870603_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGSKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGNVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NZ_CP040230.1|WP_000520233.1|869068_869764_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NZ_CP040230.1|WP_000571213.1|868050_869076_+|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHTVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NZ_CP040230.1|WP_001065802.1|867504_867801_+|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFQSVTDLLENLK
>NZ_CP040230.1|WP_001018957.1|867125_867512_+|hypothetical-protein
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKFDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPFLPNINNERLVLVNE
>NZ_CP040230.1|WP_000932205.1|865545_866424_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPILPCIEMDLKEMQEETLNQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLDDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPISDLSLKDIQAHLKSLNADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQGLKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NZ_CP040230.1|WP_000662306.1|865430_865544_+|hypothetical-protein
MKENLLGTIIWSIATFYYSRMMKIMNLAILKIKIGGS
>NZ_CP040230.1|WP_000290492.1|864985_865366_+|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEVSDESQLEALLSAEKYAEMIGE
>NZ_CP040230.1|WP_000589549.1|864471_864828_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NZ_CP040230.1|WP_000752917.1|871410_871605_+|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>NZ_CP040230.1|WP_001183849.1|871838_872690_-|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNGDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEFVKLNFAGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>NZ_CP040230.1|WP_000168845.1|873017_873779_+|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>NZ_CP040230.1|WP_138742458.1|873877_875185_+|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYFKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKYFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDENASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK
>NZ_CP040230.1|WP_000807673.1|875299_876541_+|cysteine-desulfurase
MAEHSFDVNEVIKDFPILDQKVNGKRLAYLDSTATSQTPVQVLNVLEDYYKRYNSNVHRGVHTLGSLATDGYENARETVRRFINAKYFEEIIFTRGTTASINLVAHSYGDANVEEGDEIVVTEMEHHANIVPWQQLAKRKNATLKFIPMTADGELNIEDIKQTINDKTKIVAIAHISNVLGTINDVKTIAEIAHQHGAIISVDGAQAAPHMKLDMQEMNADFYSFSGHKMLGPTGIGVLFGKRELLQKMEPIEFGGDMIDFVSKYDATWADLPTKFEAGTPLIAQAIGLAEAIRYLERIGFDAIHKYEQELTIYAYEQMSTIEGIEIYGPPKDRRAGVITFNLQDVHPHDVATAVDTEGVAVRAGHHCAQPLMKWLNVSSTARASFYIYNTKEDIDQLINALKQTKEFFSYEF
>NZ_CP040230.1|WP_001010508.1|876530_876995_+|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MNFNNLDQLYRSVIMDHYKNPRNKGVLDNGSMTVDMNNPTCGDRIRLTFDIEDGIIKDAKFEGEGCSISMASASMMTQAVKGHSLGEAMQMSQEFTKMMLGEDYVITEEMGDIEALQGVSQFPARIKCATLAWKALEKGTVAKEGKAEGTTEEE
>NZ_CP040230.1|WP_001074405.1|877145_878543_+|Fe-S-cluster-assembly-protein-SufB
MAKKAPDVGDYKYGFHDDDVSIFRSERGLTENIVREISNMKNEPEWMLDFRLKSLKLFYKMPMPQWGGDLSELNFDDITYYVKPSEQAERSWDEVPEEIKRTFDKLGIPEAEQKYLAGVSAQYESEVVYHNMEKELEEKGIIFKDTDSALQENEELFKKYFASVVPAADNKFAALNSAVWSGGSFIYVPKNIKLDTPLQAYFRINSENMGQFERTLIIADEGASVHYVEGCTAPVYTTSSLHSAVVEIIVHKDAHVRYTTIQNWANNVYNLVTKRTFVYENGNMEWVDGNLGSKLTMKYPNCVLLGEGAKGSTLSIAFAGKGQVQDAGAKMIHKAPNTSSTIVSKSISKNGGKVIYRGIVHFGRKAKGARSNIECDTLILDNESTSDTIPYNEVFNDQISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAVEMNRLIKFEMEGSIG
>NZ_CP040230.1|WP_000274033.1|878874_879189_-|hypothetical-protein
MYFVLAIFTIISASVSLGYSIQACASSHNINAYYALSRSLPLFLLAIFSLVIHSAIFLITISIAMILVQFLDAIVGYKSNDVFKTYGPLATSVVNLILLIVFLF
>NZ_CP040230.1|WP_000582322.1|879557_880598_+|DUF21-domain-containing-protein
MIIAIIILIFISFFFSGSETALTAANKTKFKTEADKGDKKAKGIVKLLEKPSEFITTILIGNNVANILLPTLVTIMALRWGISVGIASAVLTVVIILISEVIPKSVAATFPDKITRLVYPIINICVIVFRPITLLLNKLTDSINRCLSKGQPQEHQFSKEEFKTMLAIAGHEGALNEIETSRLEGVINFENLKVKDVDTTPRINVTAFASNATYEEVYETVMNKPYTRYPVYEGDIDNIIGVFHSKYLLAWSNKKEDQITNYSAKPLFVNEHNKAEWVLRKMTISRKHLAIVLDEFGGTEAIVSHEDLIEELLGMEIEDEMDKKEKEKLSQQQIQFQQRKNRNVSI
>NZ_CP040230.1|WP_000267231.1|880611_881679_+|nitronate-monooxygenase
MWNKNRLTQMLSIEFPIIQAGMAGSTTPKLVASVSNSGGLGTIGAGYFNTQQLEDEIDYVRQLTSNSFGVNVFVPSQQSYTSNQIENMNAWLKPYRRALHLEEPVVKITEEQQFKCHIDTIIKKQVPVCCFTFGIPNESIIKRLKEANIKLIGTATSVDEAIANEKAGMDAIVAQGSEAGGHRGSFLKPKNQLPMVGTISLVPQIVDVVSIPVIAAGGIMDGRGVLASIVLGAEGVQMGTAFLTSQDSNASELLRDAIINSKETDTVITKAFSGKLARGINNRFIEEMSQYEGDIPDYPIQNELTSSIRKAAANIGDKELTHMWSGQSPRLATTHPANTIMSNIINQINQIMQYK

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Crispr_ID: NZ_CP040230_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_4

1724599-1724732

Orphan

Consensus_repeat	Method
TGCAAGTTGGGCTGGGGCCCCAACATAGAGAA	PILER-CR
TGCAAGTTGGGGTGGGGCCCCAACATAGA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP040230_4

>merge|NZ_CP040230|4|1724599-1724732|PILER-CR,CRISPRCasFinder
GGGGCCCCAACATAGAGAATTTCGAAAAGAAATTCTACAAACAATGCAAGTTGGGGTGGGGCCCCAACATAGAAGGTGACGTAATGTCAGCTTACTTTAATGTGCAAGTTGGGCTGGGGCCCCAACATAGAGAA

>NZ_CP040230|4|1|1724599-1724732|PILER-CR
GGGGCCCCAACATAGAGAATTTCGAAAAGAAA	TTCTACAAACAATGCAAGTTGGGGT
GGGGCCCCAACATAGAAGGTGACGTAATGTCA	GCTTACTTTAATGTGCAAGTTGGGCTGGG
GCCCCAACATAGAGAA

>NZ_CP040230|4|4|1724643-1724729|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACATAGA	AGGTGACGTAATGTCAGCTTACTTTAATG
TGCAAGTTGGGCTGGGGCCCCAACATAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000123161.1\|1709110_1710379_-\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NZ_CP040230.1\|WP_000883646.1\|1716617_1717562_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_CP040230.1\|WP_000818532.1\|1711896_1713258_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP040230.1\|WP_000829167.1\|1710427_1711549_-\|citrate-synthase	unknown	unknown	gnl\|CDD\|184468
NZ_CP040230.1\|WP_000777188.1\|1727242_1727932_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_CP040230.1\|WP_000160430.1\|1724820_1726119_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NZ_CP040230.1\|WP_138742475.1\|1728106_1729162_+\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|223085
NZ_CP040230.1\|WP_000040067.1\|1731483_1732686_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP040230.1\|WP_000365308.1\|1734435_1735206_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP040230.1\|WP_000471571.1\|1717561_1718419_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_CP040230.1\|WP_000058389.1\|1718613_1719843_-\|NAD-dependent-malic-enzyme-4	unknown	unknown	gnl\|CDD\|235976
NZ_CP040230.1\|WP_000626092.1\|1723509_1724451_-\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NZ_CP040230.1\|WP_000136251.1\|1733843_1734338_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NZ_CP040230.1\|WP_000717561.1\|1715380_1716349_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP040230.1\|WP_000634175.1\|1730736_1731237_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP040230.1\|WP_000840583.1\|1732773_1733721_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_CP040230.1\|WP_138742474.1\|1720291_1723489_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_CP040230.1\|WP_000690004.1\|1729477_1730596_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP040230.1\|WP_001232654.1\|1713601_1715359_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NZ_CP040230.1\|WP_000277602.1\|1726323_1726737_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000123161.1\|1709110_1710379_-\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP040230.1\|WP_000883646.1\|1716617_1717562_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_CP040230.1\|WP_000818532.1\|1711896_1713258_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP040230.1\|WP_000829167.1\|1710427_1711549_-\|citrate-synthase	gnl\|CDD\|184468	PRK14035, PRK14035, citrate synthase; Provisional.	0
NZ_CP040230.1\|WP_000777188.1\|1727242_1727932_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	3.09103e-133
NZ_CP040230.1\|WP_000160430.1\|1724820_1726119_-\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NZ_CP040230.1\|WP_138742475.1\|1728106_1729162_+\|M24-family-metallopeptidase	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	5.78227e-127
NZ_CP040230.1\|WP_000040067.1\|1731483_1732686_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP040230.1\|WP_000365308.1\|1734435_1735206_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.0657e-38
NZ_CP040230.1\|WP_000471571.1\|1717561_1718419_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_CP040230.1\|WP_000058389.1\|1718613_1719843_-\|NAD-dependent-malic-enzyme-4	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_CP040230.1\|WP_000626092.1\|1723509_1724451_-\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	5.72376e-100
NZ_CP040230.1\|WP_000136251.1\|1733843_1734338_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	7.99696e-100
NZ_CP040230.1\|WP_000717561.1\|1715380_1716349_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NZ_CP040230.1\|WP_000634175.1\|1730736_1731237_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
NZ_CP040230.1\|WP_000840583.1\|1732773_1733721_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	6.63876e-57
NZ_CP040230.1\|WP_138742474.1\|1720291_1723489_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_CP040230.1\|WP_000690004.1\|1729477_1730596_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP040230.1\|WP_001232654.1\|1713601_1715359_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NZ_CP040230.1\|WP_000277602.1\|1726323_1726737_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19

>NZ_CP040230.1|WP_000626092.1|1723509_1724451_-|pApA-hydrolase-Pde2
MISTMNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGRKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLKQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLAKALRTKLN
>NZ_CP040230.1|WP_138742474.1|1720291_1723489_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDTCIANNIKPIFGMTIYVTNGLNTVETVVLAKDNNGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKNVADEHRDIVQVFDSHEDTYLDHRSVLVQGIKHVWIQDVCYQTRHDADTISALAAIRDNTKLDLIHDQEDFGAHFLTENEIQQLDVNPEYFTQADRIAQKCDAELKYHQSLLPQYQAPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRREKVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIRTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVEERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDLRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>NZ_CP040230.1|WP_000058389.1|1718613_1719843_-|NAD-dependent-malic-enzyme-4
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTMAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NZ_CP040230.1|WP_000471571.1|1717561_1718419_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NZ_CP040230.1|WP_000883646.1|1716617_1717562_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NZ_CP040230.1|WP_000717561.1|1715380_1716349_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NZ_CP040230.1|WP_001232654.1|1713601_1715359_-|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIEEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NZ_CP040230.1|WP_000818532.1|1711896_1713258_+|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAYKTQFGHASFTNLYEHGVFPKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKKATYKLFGGKYMGYLIFVFFIFVFGLLFINVETRRAIYFIPIWFILLGFMYLRYKRIAAKSNN
>NZ_CP040230.1|WP_000829167.1|1710427_1711549_-|citrate-synthase
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDAYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>NZ_CP040230.1|WP_000123161.1|1709110_1710379_-|NADP-dependent-isocitrate-dehydrogenase
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVEKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK
>NZ_CP040230.1|WP_000160430.1|1724820_1726119_-|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVIDFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANQTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NZ_CP040230.1|WP_000277602.1|1726323_1726737_+|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NZ_CP040230.1|WP_000777188.1|1727242_1727932_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NZ_CP040230.1|WP_138742475.1|1728106_1729162_+|M24-family-metallopeptidase
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDVDLTIKQLRNIKSEDEINKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPSQEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISKKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK
>NZ_CP040230.1|WP_000690004.1|1729477_1730596_-|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDNPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NZ_CP040230.1|WP_000634175.1|1730736_1731237_+|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>NZ_CP040230.1|WP_000040067.1|1731483_1732686_-|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVDGEKVKTVQDIKDHVEAVDIMLDAFKKHNIINDINDIDGTGHRVVHGGEKFPESAAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLQRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTYGGLK
>NZ_CP040230.1|WP_000840583.1|1732773_1733721_-|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSRDFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NZ_CP040230.1|WP_000136251.1|1733843_1734338_-|thiol-peroxidase
MTEITFKGGPIHLKGQLINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>NZ_CP040230.1|WP_000365308.1|1734435_1735206_-|TSUP-family-transporter
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSAIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLIFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLVMAASMIVGSYAGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFV

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Crispr_ID: NZ_CP040230_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_5

1727063-1727145

Orphan

Consensus_repeat	Method
GAAGCTGACGAAAAAGTCAGCTTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_5

>merge|NZ_CP040230|5|1727063-1727145|CRISPRCasFinder
GAAGCTGACGAAAAAGTCAGCTTACTATAATGTGCAAGTTGGGGTGGGCCCCAACACAGAAGCTGACGAAAAAGTCAGCTTAC

>NZ_CP040230|5|5|1727063-1727145|CRISPRCasFinder
GAAGCTGACGAAAAAGTCAGCTTAC	TATAATGTGCAAGTTGGGGTGGGCCCCAACACA
GAAGCTGACGAAAAAGTCAGCTTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000883646.1\|1716617_1717562_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_CP040230.1\|WP_000818532.1\|1711896_1713258_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|224038
NZ_CP040230.1\|WP_072434776.1\|1736472_1737621_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP040230.1\|WP_138742475.1\|1728106_1729162_+\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|223085
NZ_CP040230.1\|WP_000777188.1\|1727242_1727932_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
NZ_CP040230.1\|WP_000160430.1\|1724820_1726119_-\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226594
NZ_CP040230.1\|WP_000690004.1\|1729477_1730596_-\|alanine-dehydrogenase	unknown	unknown	gnl\|CDD\|240630
NZ_CP040230.1\|WP_000040067.1\|1731483_1732686_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP040230.1\|WP_000365308.1\|1734435_1735206_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP040230.1\|WP_000471571.1\|1717561_1718419_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
NZ_CP040230.1\|WP_000058389.1\|1718613_1719843_-\|NAD-dependent-malic-enzyme-4	unknown	unknown	gnl\|CDD\|235976
NZ_CP040230.1\|WP_000626092.1\|1723509_1724451_-\|pApA-hydrolase-Pde2	unknown	unknown	gnl\|CDD\|223691
NZ_CP040230.1\|WP_000136251.1\|1733843_1734338_-\|thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
NZ_CP040230.1\|WP_000717561.1\|1715380_1716349_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP040230.1\|WP_000634175.1\|1730736_1731237_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP040230.1\|WP_000840583.1\|1732773_1733721_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|223897
NZ_CP040230.1\|WP_138742474.1\|1720291_1723489_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_CP040230.1\|WP_001232654.1\|1713601_1715359_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
NZ_CP040230.1\|WP_000277602.1\|1726323_1726737_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP040230.1\|WP_000872673.1\|1735249_1736473_-\|tRNA-4-thiouridine(8)-synthase-ThiI	unknown	unknown	gnl\|CDD\|234960

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000883646.1\|1716617_1717562_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_CP040230.1\|WP_000818532.1\|1711896_1713258_+\|amino-acid-permease	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
NZ_CP040230.1\|WP_072434776.1\|1736472_1737621_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.21752e-165
NZ_CP040230.1\|WP_138742475.1\|1728106_1729162_+\|M24-family-metallopeptidase	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	5.78227e-127
NZ_CP040230.1\|WP_000777188.1\|1727242_1727932_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	3.09103e-133
NZ_CP040230.1\|WP_000160430.1\|1724820_1726119_-\|CBS-domain-containing-protein	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
NZ_CP040230.1\|WP_000690004.1\|1729477_1730596_-\|alanine-dehydrogenase	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
NZ_CP040230.1\|WP_000040067.1\|1731483_1732686_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP040230.1\|WP_000365308.1\|1734435_1735206_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	1.0657e-38
NZ_CP040230.1\|WP_000471571.1\|1717561_1718419_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
NZ_CP040230.1\|WP_000058389.1\|1718613_1719843_-\|NAD-dependent-malic-enzyme-4	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
NZ_CP040230.1\|WP_000626092.1\|1723509_1724451_-\|pApA-hydrolase-Pde2	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	5.72376e-100
NZ_CP040230.1\|WP_000136251.1\|1733843_1734338_-\|thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	7.99696e-100
NZ_CP040230.1\|WP_000717561.1\|1715380_1716349_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
NZ_CP040230.1\|WP_000634175.1\|1730736_1731237_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
NZ_CP040230.1\|WP_000840583.1\|1732773_1733721_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	6.63876e-57
NZ_CP040230.1\|WP_138742474.1\|1720291_1723489_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_CP040230.1\|WP_001232654.1\|1713601_1715359_-\|pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
NZ_CP040230.1\|WP_000277602.1\|1726323_1726737_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
NZ_CP040230.1\|WP_000872673.1\|1735249_1736473_-\|tRNA-4-thiouridine(8)-synthase-ThiI	gnl\|CDD\|234960	PRK01565, PRK01565, thiamine biosynthesis protein ThiI; Provisional.	0

>NZ_CP040230.1|WP_000277602.1|1726323_1726737_+|universal-stress-protein
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>NZ_CP040230.1|WP_000160430.1|1724820_1726119_-|CBS-domain-containing-protein
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVIDFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANQTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>NZ_CP040230.1|WP_000626092.1|1723509_1724451_-|pApA-hydrolase-Pde2
MISTMNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGRKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLKQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLAKALRTKLN
>NZ_CP040230.1|WP_138742474.1|1720291_1723489_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDTCIANNIKPIFGMTIYVTNGLNTVETVVLAKDNNGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKNVADEHRDIVQVFDSHEDTYLDHRSVLVQGIKHVWIQDVCYQTRHDADTISALAAIRDNTKLDLIHDQEDFGAHFLTENEIQQLDVNPEYFTQADRIAQKCDAELKYHQSLLPQYQAPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRREKVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIRTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVEERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDLRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>NZ_CP040230.1|WP_000058389.1|1718613_1719843_-|NAD-dependent-malic-enzyme-4
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTMAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>NZ_CP040230.1|WP_000471571.1|1717561_1718419_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>NZ_CP040230.1|WP_000883646.1|1716617_1717562_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>NZ_CP040230.1|WP_000717561.1|1715380_1716349_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>NZ_CP040230.1|WP_001232654.1|1713601_1715359_-|pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIEEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>NZ_CP040230.1|WP_000818532.1|1711896_1713258_+|amino-acid-permease
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAYKTQFGHASFTNLYEHGVFPKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKKATYKLFGGKYMGYLIFVFFIFVFGLLFINVETRRAIYFIPIWFILLGFMYLRYKRIAAKSNN
>NZ_CP040230.1|WP_000777188.1|1727242_1727932_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKKTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>NZ_CP040230.1|WP_138742475.1|1728106_1729162_+|M24-family-metallopeptidase
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDVDLTIKQLRNIKSEDEINKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPSQEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISKKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGYEVLTHYEK
>NZ_CP040230.1|WP_000690004.1|1729477_1730596_-|alanine-dehydrogenase
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEEKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDNPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>NZ_CP040230.1|WP_000634175.1|1730736_1731237_+|universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>NZ_CP040230.1|WP_000040067.1|1731483_1732686_-|acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVDGEKVKTVQDIKDHVEAVDIMLDAFKKHNIINDINDIDGTGHRVVHGGEKFPESAAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLQRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTYGGLK
>NZ_CP040230.1|WP_000840583.1|1732773_1733721_-|class-I-SAM-dependent-methyltransferase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSRDFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>NZ_CP040230.1|WP_000136251.1|1733843_1734338_-|thiol-peroxidase
MTEITFKGGPIHLKGQLINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>NZ_CP040230.1|WP_000365308.1|1734435_1735206_-|TSUP-family-transporter
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSAIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLIFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLVMAASMIVGSYAGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFV
>NZ_CP040230.1|WP_000872673.1|1735249_1736473_-|tRNA-4-thiouridine(8)-synthase-ThiI
MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTLEAMSATAIKFAQQFEENSTFKIDVKRADKNYPMDTYELQRELGGAVLKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVQGAGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGAYAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
>NZ_CP040230.1|WP_072434776.1|1736472_1737621_-|cysteine-desulfurase
MFILIYLDNAATTKAFEEVLDTYLKVNQSMYYNPNSPHKAGLQADQLLQQAKVQINDMVNTNMTYDVVFTSGATESNNIALKGVAYRKFDTAREIITSVLEHPSVLEVVRYLEEREGFKVKYVDVTKDGSINLEHFKELMSDKVGLVTCMYVNNVTGQIQPIPQMADVIKNYPKAHFHVDAVQAFGKISMDFNNVDSISLSGHKFNGLKGQGVLLVNHIQNVEPTVHGGGQEYGVRSGTVNLPNDIAMVKAMKIANENLEALNAFVTELNNDVRQFLNKYHGVYINSSTSGSPFVLNVSFPGVKGEVLVNAFSKYDIMISTTSACSSKRNKLNEVLTAMGLSDKAIEGSIRLSFGAMTTKEDITKFKETFTIIYEEIKELLK

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Crispr_ID: NZ_CP040230_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_6

1816489-1816582

Orphan

Consensus_repeat	Method
GCAATGCGCGTTGGGGTGTGGGGCCCCAACATAG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP040230_6

>merge|NZ_CP040230|6|1816489-1816582|CRISPRCasFinder
GCAATGCGCGTTGGGGTGTGGGGCCCCAACATAGAGAATTTCAAAAAAGAAATTCTACAGGCAATGCGCGTTGGGGTGTGGGGCCTCAACATAG

>NZ_CP040230|6|6|1816489-1816582|CRISPRCasFinder
GCAATGCGCGTTGGGGTGTGGGGCCCCAACATAG	AGAATTTCAAAAAAGAAATTCTACAG
GCAATGCGCGTTGGGGTGTGGGGCCTCAACATAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000384171.1\|1812582_1812807_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001153741.1\|1813588_1814032_+\|competence-protein-ComK	unknown	unknown	gnl\|CDD\|368849
NZ_CP040230.1\|WP_001030475.1\|1814018_1814462_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000933822.1\|1821316_1822510_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP040230.1\|WP_000091443.1\|1817716_1818019_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000366160.1\|1820283_1821192_-\|NERD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377990
NZ_CP040230.1\|WP_000492903.1\|1815561_1816182_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP040230.1\|WP_001032832.1\|1811452_1812307_-\|autolysin	unknown	unknown	gnl\|CDD\|226656
NZ_CP040230.1\|WP_000671058.1\|1813005_1813476_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_CP040230.1\|WP_000453302.1\|1819238_1820072_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223729
NZ_CP040230.1\|WP_000109913.1\|1822881_1824474_+\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|238270
NZ_CP040230.1\|WP_001096494.1\|1816744_1817458_-\|transaldolase	unknown	unknown	gnl\|CDD\|183481
NZ_CP040230.1\|WP_000221190.1\|1809759_1810074_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP040230.1\|WP_001261673.1\|1807614_1809117_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|226906
NZ_CP040230.1\|WP_000672013.1\|1825521_1825995_-\|nucleoside-triphosphatase-YtkD	unknown	unknown	gnl\|CDD\|131752
NZ_CP040230.1\|WP_000623484.1\|1818635_1818989_+\|CrcB-family-protein	unknown	unknown	gnl\|CDD\|223317
NZ_CP040230.1\|WP_000989103.1\|1810073_1811366_+\|arsenite-efflux-transporter-membrane-subunit-ArsB	unknown	unknown	gnl\|CDD\|185342
NZ_CP040230.1\|WP_016187361.1\|1824770_1825517_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224423
NZ_CP040230.1\|WP_001168915.1\|1814759_1815395_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP040230.1\|WP_001200546.1\|1818273_1818639_+\|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl\|CDD\|184566

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_001153741.1\|1813588_1814032_+\|competence-protein-ComK	gnl\|CDD\|368849	pfam06338, ComK, ComK protein. This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level.	0.00341613
NZ_CP040230.1\|WP_000933822.1\|1821316_1822510_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP040230.1\|WP_000109913.1\|1822881_1824474_+\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|238270	cd00484, PEPCK_ATP, Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate to yield phosphoenolpyruvate and carbon dioxide, using a nucleotide molecule (ATP) for the phosphoryl transfer, and has a strict requirement for divalent metal ions for activity. PEPCK's separate into two phylogenetic groups based on their nucleotide substrate specificity, this model describes the ATP-dependent groups.	0
NZ_CP040230.1\|WP_000366160.1\|1820283_1821192_-\|NERD-domain-containing-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	0.0097287
NZ_CP040230.1\|WP_000492903.1\|1815561_1816182_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.95394e-14
NZ_CP040230.1\|WP_001032832.1\|1811452_1812307_-\|autolysin	gnl\|CDD\|226656	COG4193, LytD, Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].	1.03813e-119
NZ_CP040230.1\|WP_000671058.1\|1813005_1813476_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	4.63508e-17
NZ_CP040230.1\|WP_000453302.1\|1819238_1820072_-\|aldo/keto-reductase	gnl\|CDD\|223729	COG0656, ARA1, Aldo/keto reductases, related to diketogulonate reductase [General function prediction only].	3.63054e-136
NZ_CP040230.1\|WP_001096494.1\|1816744_1817458_-\|transaldolase	gnl\|CDD\|183481	PRK12376, PRK12376, putative translaldolase; Provisional.	1.22733e-152
NZ_CP040230.1\|WP_000221190.1\|1809759_1810074_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	3.46552e-20
NZ_CP040230.1\|WP_001261673.1\|1807614_1809117_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|226906	COG4529, COG4529, Uncharacterized protein conserved in bacteria [Function unknown].	7.76857e-169
NZ_CP040230.1\|WP_000672013.1\|1825521_1825995_-\|nucleoside-triphosphatase-YtkD	gnl\|CDD\|131752	TIGR02705, conserved_hypothetical_protein, nucleoside triphosphatase YtkD. The functional assignment to the proteins of this family is contentious, with papers disagreeing in both interpretation and enzyme assay results. This protein belongs to the nudix family and shares some sequence identity with E. coli MutT but appears not to be functionally interchangeable with it. [DNA metabolism, DNA replication, recombination, and repair].	1.61742e-84
NZ_CP040230.1\|WP_000623484.1\|1818635_1818989_+\|CrcB-family-protein	gnl\|CDD\|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	2.17815e-24
NZ_CP040230.1\|WP_000989103.1\|1810073_1811366_+\|arsenite-efflux-transporter-membrane-subunit-ArsB	gnl\|CDD\|185342	PRK15445, PRK15445, arsenical efflux pump membrane protein ArsB.	0
NZ_CP040230.1\|WP_016187361.1\|1824770_1825517_-\|S9-family-peptidase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	2.57837e-50
NZ_CP040230.1\|WP_001168915.1\|1814759_1815395_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.66953e-13
NZ_CP040230.1\|WP_001200546.1\|1818273_1818639_+\|fluoride-efflux-transporter-CrcB	gnl\|CDD\|184566	PRK14201, PRK14201, fluoride efflux transporter CrcB.	1.84114e-55

>NZ_CP040230.1|WP_000492903.1|1815561_1816182_+|CPBP-family-intramembrane-metalloprotease
MFSRNNNIFVDDLSVTKDNYLIAVLKMLVIFLVINYGTDVSYDHEYVGLFIILLGVVLLKILNINLLSFKKLKFTHMLYIIFGFLLMYGLDYLYDTFAPPTLNEILIDEESEDAPYHIALLSTAIIPPITEEIICRGLIIRILFRNHLFLGFIVSTVFFTLIHESDTLIGYLPYFYSGLIFGYTYLKTKRLEVPILIHFINNLLAM
>NZ_CP040230.1|WP_001168915.1|1814759_1815395_+|CPBP-family-intramembrane-metalloprotease
MQKFKDLFYDDLSVARGNYFLTLLSAFLITIILLIGFVVSDTHILYGVFIVLIGIVLLRLFKINLLSFKKLTMSQVIYIIGGALLIYGLDYLYLHFHDVPTNEQELDRELQHMPLYMSIVTIAIIPAIVEEIVFRGMIIRVVFRKHLFIGLVVSSLVFASLHESDTWIGYLPYLYSGVIFGLIYLKTKRLEVVILIHFINNLSSLLILLWG
>NZ_CP040230.1|WP_001030475.1|1814018_1814462_-|hypothetical-protein
MNKASFDKKVKKQLWFLNKKEKQALDQRLSSITDKDNVNFNKPITFANTYLRENVFRSKETKSYSIFVTLVVMMFAYVALLGLFLFGLITSLSGVQFFVNPKVDLSTTVVILTIIGAILLMLVSIYLIKITTSYFTKKLLEHKFNGH
>NZ_CP040230.1|WP_001153741.1|1813588_1814032_+|competence-protein-ComK
MQDNSTKYLLYIQTATSNHLETNCVFLHCDYILKVPINKLVSYYAKLHLSSQSVLIETAKNILNINKLVPIYINAKTILFPLKHKRAPIQIYINAHYIVGMTAIENSTLIHFQEGIQLEVDEPFSLVSKKCHESLALKHFIENTNDH
>NZ_CP040230.1|WP_000671058.1|1813005_1813476_+|RNA-polymerase-sigma-factor
MKFNDVYNKHHKIIHHLLKKYNISYNYDEYYQLLLIKMWQLSQIYKPSSNQSLSSFLFMRLNFYLIDLFRQQKRLNDIILCENHSPILTEQPTYFNEYDLRLQDVCALLKHRERQWLMLYLEGYKQYEIADIMSLSTSTIKLIKASVKRKCQRFLN
>NZ_CP040230.1|WP_000384171.1|1812582_1812807_-|hypothetical-protein
MDYAHLNLEHFFARNDDLDVIRDRADFVMINNFTNEMMYRDGQIEGTIDLNQYYYKNRSNAASFIMMDYKKETK
>NZ_CP040230.1|WP_001032832.1|1811452_1812307_-|autolysin
MNKHKKGSIFGIIGLVVIFAVVSFLFFSMISDQIFFKHVKSDIKIEKLNVTLNDAAKKQINNYTSQQVSNKKNDAWRDASATEIKSAMDSGTFIDNEKQKYQFLDLSKYQGIDKNRIKRMLVDRPTLLKHTDDFLKAAKDKHVNEVYLISHALLETGAVKSELANGVEIDGKKYYNFYGVGALDKDPIKTGAEYAKKHGWDTPEKAISGGADFIHKHFLSSTDQNTLYSMRWNPKNPGEHQYATDIKWAESNATIIADFYKNMKTEGKYFKYFVYKDDSKHLKK
>NZ_CP040230.1|WP_000989103.1|1810073_1811366_+|arsenite-efflux-transporter-membrane-subunit-ArsB
MMTTLATFIFLVTLLFVLWQPKGLDIGFTALAGAFIAVITGVVSFSDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIHMLHASKGSGLKMFVYIILLGAVVAAFFANDGAALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNIISADYFNISFSQYLSRMIIPNLFSLLASLLVLWLYFRKAIPKSFDANHIKKPIDAINDLKLFKISWIVLVILLFGYLISEFTKIPVSIFTGIIAFIFLILARKSNAVNIKQVIKGAPWNIVLFSIGMYIVIFGLRNAGITLILAKILEYISNYGLFSTILGMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTYFKTGIIITIPVLFFTLIGLYLTLILF
>NZ_CP040230.1|WP_000221190.1|1809759_1810074_+|winged-helix-turn-helix-transcriptional-regulator
MTYKELATYLKVLSDSSRLEILDLLSCGELCACDLLEHFQFSQPTLSYHMKALVKTNLVTTRKIGNKHLYQLNHNIFESVINNLSKVHTSNQRCICHNLKTGEC
>NZ_CP040230.1|WP_001261673.1|1807614_1809117_-|FAD-dependent-oxidoreductase
MRVAIIGMGTAGVSVLRELVKHPKFNQLDIDLYDDKVNMGQGVPFQNDSSELLINMPSKKMSLNLDDETEFWKWYKQQTDFNFDEPAYLPRFVFGHYMKSYLSMFTKKYPNISTNYNKVQEIYTNSNIDETNLTYYICTTNSEQSWQAYDYVFLTCGTFAYHDPYNLKGKKGYIATPYPTYNTLDEVNELDDIAIIGTGLASLDVVRYVAAHHPKLPITMTSRSANLPSVRGTMIDVTFKYLTKDKLNDIKKHHFGNAPLDTLVSLFLKECAEYDIDFEKLVHRRTGNHIADLKYDLARPTEMGIFQSIIEHLKENLNWIWNSLSIEDQHQFNQKYSKMIQLNSNPMPPRTAELIIELIENKSLILKKDLEDVKHDGKLYYFSYKNQESVDIYKVVINATGAKSHLNELDQDDQLIKNLENRQIVQAHPMGGIQIIPETNQVISPRFGTLTNMIAIGQMTNGVNKLRNGVKMIVEQVAHTVSQLYDALESNEQEQRSDNQ
>NZ_CP040230.1|WP_001096494.1|1816744_1817458_-|transaldolase
MAKLNVEVFADGADIEEMKAAYKNKQVDGFTTNPSLMAKAGVTDYKAFAEEAVKEIPDASISFEVFADDLETMEKEAAILKQYGENVFVKIPIVNTKGESTIPLIKKLSADNVRLNVTAVYTIEQVKEITEAVTEGVPTYVSVFAGRIADTGVDPLPLMKEAVKVTHSKDGVKLLWASCRELFNVIQADEIGADIITCPADVVKKVNTNLGRDINELSVDTVKGFAKDIQSSGLSIL
>NZ_CP040230.1|WP_000091443.1|1817716_1818019_+|hypothetical-protein
MSRSKKYFYLSSLMIILSFFFNTNNVFLSGLFNSFIKLILFCSVINSIILILSIIFADRSIKSLKPDADWIRIASKSLPWIILIVILVHIFSIVHTFGFI
>NZ_CP040230.1|WP_001200546.1|1818273_1818639_+|fluoride-efflux-transporter-CrcB
MQYVYIFIGGALGALLRYLISFLNTDGGFPIGTLIANLTGAFVMGLLTALTIEFFSNHPTLKKAITTGFLGALTTFSTFQLELIHMFDYQQFITLLLYAVTSYVFGILLCYVGIKLGGGLS
>NZ_CP040230.1|WP_000623484.1|1818635_1818989_+|CrcB-family-protein
MISIILVMIGGGLGAIARSAVTDYFNHIFTSKLPIATLIVNLVGSFLIGLTIGLSISISWFPAFFVTGFLGGLTTFSTLAKELTLMMTPKFDIKLFLNYSLLQFIIGFIACYIGYHI
>NZ_CP040230.1|WP_000453302.1|1819238_1820072_-|aldo/keto-reductase
MEVKTFYNGNTMPQIGLGTFRVENDENCMESVKYAIEQGYRSIDTAKVYGNEEQVGAGIRAGLESTGIAREDLFITSKLYFEDFGRENVAAAYEASLSRLGLKYLDLYLVHWPGTNEAIMVDTWKGMEDLYKNNKVKNIGVSNFEPEHLEALLAQVSIKPVINQVEYHPYLTQHKLKLYLAAQHIVMESWSPLMNAQILNDETIKDIAQELGKSPAQVVLRWNVQHGVVTIPKSVTPNRISENFRIFDFELSDEQMTRIDDLNQDKRIGPDPKTFEG
>NZ_CP040230.1|WP_000366160.1|1820283_1821192_-|NERD-domain-containing-protein
MDLSSPVVIGLIIAVVIALIFFVLFLVALGSKKKVKRQTEEKYEQQEQNIKKSHEEALEKERIQNKKTITKQQEDYNHMISTKDREIDALKLFSKNHSEYVTDMRLIGIRERLVKEKRIRPEDMHIMANIFLPKDGFNNIERISHLVLTRTGLYIIDSQLLKGHVYNGISGGQFKDLPPMEQVFDTLDLDKSRPQTIVMDQNDDKRSLSFVNYSDQIEAIKQLAEDLQKHLGAKYTPTSILYFNPKNEGDVTISNYNQNSAVKVLVGAEQLDEFFNKFVFHGRIQYNVEDLQQMMDKIESFN
>NZ_CP040230.1|WP_000933822.1|1821316_1822510_-|methionine-adenosyltransferase
MLNNKRLFTSESVTEGHPDKIADQVSDAILDAILKDDPNARVACETTVTTGMALIAGEISTTTYVDIPKVVRETIKEIGYTRAKYGYDYETMAILTAIDEQSPDIAQGVDKALEYRDKDSEEEIEATGAGDQGLMFGYATNETETYMPLAIYLSHQLAKRLSDVRKDGTLNYLRPDGKVQVTVEYDENDNPVRIDTIVVSTQHAEDVTLEQIQEDIKAHVIYPTVPENLINEQTKFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGCFSGKDPTKVDRSAAYAARYVAKNIVAAGLADQCEVQLAYAIGVAEPVSIAIDTFGTGKVSEGQLVEAVRKHFDLRPAGIIKMLDLKQPIYKQTAAYGHFGRTDVLFPWEKLDKVEELKDAVK
>NZ_CP040230.1|WP_000109913.1|1822881_1824474_+|phosphoenolpyruvate-carboxykinase-(ATP)
MSVDTYTETTKIDKLLKKPTSHFQLSTTQLYNKILDNNEGVLTELGAVNASTGKYTGRSPKDKFFVSEPSYRDNIDWGEINQPIDEETFLKLYHKVLDYLDKKDELYVFKGYAGSDKDTMLKLTVINELAWHNLFAKNMFIRPESKEEATKIKPNFTIVSAPHFKADPEVDGTKSETFVIISFKHKVILIGGTEYAGEMKKGIFSVMNYLLPMQDIMSMHCSANVGEKGDVALFFGLSGTGKTTLSADPHRKLIGDDEHGWNKNGVFNIEGGCYAKAINLSKEKEPQIFDAIKYGAILENTVVSEDGSVDFEDNRYTENTRAAYPINHIDNIVVPSKAAHPNTIIFLTADAFGVIPPISKLNKDQAMYHFLSGFTSKLAGTERGVTEPEPSFSTCFGAPFFPLHPTVYADLLGELIDLHDVDVYLVNTGWTGGKYGVGRRISLHYTRQMVNQAISGKLKNAKYTKDSTFGLSIPVEIEDVPKTILNPINAWSDKEKYKAQAEDLIQRFEKNFEKFGEKVEHIAEKGSFNK
>NZ_CP040230.1|WP_016187361.1|1824770_1825517_-|S9-family-peptidase
MPIESFTHQFEEITYLSDDLQVKALMMTPHHEVKRIVVYLRGGKGQVGRVRAGRLMQFSDSQTLVIGPYYRGNNGSEGKDEFYRGDLNDVTQLLRLLHDKYPQAFIHMVGFSRGGLQGLLTFQDLPVSSYIIWGGVSDIDLMYEERVDLRGMLRRMIGHPKKDRAAYEARQAIPNINENSPPILIVHGGKDQQVGIHHAYYLADQLELKGAAHETFYQMAEGHVPRPPAMVETLTYIKEFMNQVELHR
>NZ_CP040230.1|WP_000672013.1|1825521_1825995_-|nucleoside-triphosphatase-YtkD
MKFRDKDNRQVNLTFKKDNEIADGNHVLAIPTFKNQLLFTKHNLRGIEFPGGKRERGESSAEAVTRELYEETGAKVKNIHYIAQYTIETHDQTDFVKDVYFIEVESLVSKNDYLETAGPVLFNCINDIELAQRSFLLQDSTILKCVERVQSLGFYQT

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Crispr_ID: NZ_CP040230_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_7

1882972-1883099

Orphan

Consensus_repeat	Method
AATTATGGAGCGGAAGATAGGATTTACACCTATACCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_7

>merge|NZ_CP040230|7|1882972-1883099|CRISPRCasFinder
AATTATGGAGCGGAAGATAGGATTTACACCTATACCTCATTCCAGGAAGGAATGTATTCTAAGAGTTGAAATACTCCCGCATTATTATTAAATTATGGAGCGGAAGATAGGATTTGCACCTATACCTC

>NZ_CP040230|7|7|1882972-1883099|CRISPRCasFinder
AATTATGGAGCGGAAGATAGGATTTACACCTATACCTC	ATTCCAGGAAGGAATGTATTCTAAGAGTTGAAATACTCCCGCATTATTATTA
AATTATGGAGCGGAAGATAGGATTTGCACCTATACCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000251253.1\|1898095_1898638_-\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
NZ_CP040230.1\|WP_000597248.1\|1896068_1897805_-\|SAV1866-family-putative-multidrug-efflux-ABC-transporter	unknown	unknown	gnl\|CDD\|224055
NZ_CP040230.1\|WP_000116238.1\|1873610_1874996_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
NZ_CP040230.1\|WP_000901018.1\|1875191_1875587_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000939521.1\|1892665_1893121_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP040230.1\|WP_138742481.1\|1878817_1879546_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP040230.1\|WP_000669380.1\|1872334_1873156_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP040230.1\|WP_001807907.1\|1894783_1895878_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP040230.1\|WP_000181394.1\|1877064_1877535_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	unknown	unknown	gnl\|CDD\|223297
NZ_CP040230.1\|WP_000110011.1\|1891166_1891613_-\|peroxide-responsive-transcriptional-repressor-PerR	unknown	unknown	gnl\|CDD\|223806
NZ_CP040230.1\|WP_000063551.1\|1881247_1882309_-\|PTS-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226167
NZ_CP040230.1\|WP_000869465.1\|1891709_1892660_-\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240632
NZ_CP040230.1\|WP_000031108.1\|1876129_1876282_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000379101.1\|1900129_1901107_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|224899
NZ_CP040230.1\|WP_014937047.1\|1901210_1901441_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001011603.1\|1893201_1894491_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|183493
NZ_CP040230.1\|WP_000437967.1\|1871059_1872172_-\|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP040230.1\|WP_000284749.1\|1898940_1899978_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP040230.1\|WP_001251224.1\|1876306_1876906_-\|glucosamine-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223440
NZ_CP040230.1\|WP_001793998.1\|1877539_1878682_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000251253.1\|1898095_1898638_-\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	1.12131e-126
NZ_CP040230.1\|WP_000597248.1\|1896068_1897805_-\|SAV1866-family-putative-multidrug-efflux-ABC-transporter	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP040230.1\|WP_000116238.1\|1873610_1874996_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP040230.1\|WP_000110011.1\|1891166_1891613_-\|peroxide-responsive-transcriptional-repressor-PerR	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.09298e-56
NZ_CP040230.1\|WP_000939521.1\|1892665_1893121_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	1.44283e-68
NZ_CP040230.1\|WP_138742481.1\|1878817_1879546_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.20292e-152
NZ_CP040230.1\|WP_000669380.1\|1872334_1873156_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	3.57209e-78
NZ_CP040230.1\|WP_001807907.1\|1894783_1895878_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	8.3208e-87
NZ_CP040230.1\|WP_000181394.1\|1877064_1877535_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	1.70324e-88
NZ_CP040230.1\|WP_000379101.1\|1900129_1901107_+\|metal-dependent-hydrolase	gnl\|CDD\|224899	COG1988, COG1988, Predicted membrane-bound metal-dependent hydrolases [General function prediction only].	2.78861e-40
NZ_CP040230.1\|WP_000063551.1\|1881247_1882309_-\|PTS-transporter-subunit-IIC	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	1.65132e-122
NZ_CP040230.1\|WP_000869465.1\|1891709_1892660_-\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240632	cd12155, PGDH_1, Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family. Phosphoglycerate Dehydrogenase (PGDH) catalyzes the NAD-dependent conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first step in serine biosynthesis. Over-expression of PGDH has been implicated as supporting proliferation of certain breast cancers, while PGDH deficiency is linked to defects in mammalian central nervous system development. PGDH is a member of the 2-hydroxyacid dehydrogenase family, enzymes that catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	4.10993e-135
NZ_CP040230.1\|WP_001011603.1\|1893201_1894491_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|183493	PRK12389, PRK12389, glutamate-1-semialdehyde aminotransferase; Provisional.	0
NZ_CP040230.1\|WP_000437967.1\|1871059_1872172_-\|GAF-domain-containing-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.94275e-57
NZ_CP040230.1\|WP_000284749.1\|1898940_1899978_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.37898e-157
NZ_CP040230.1\|WP_001251224.1\|1876306_1876906_-\|glucosamine-6-phosphate-isomerase	gnl\|CDD\|223440	COG0363, NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism].	1.49007e-10
NZ_CP040230.1\|WP_001793998.1\|1877539_1878682_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	1.304e-179

>NZ_CP040230.1|WP_000063551.1|1881247_1882309_-|PTS-transporter-subunit-IIC
MSNAKNADNKQFFSKILNSIGAGVVIALVPNALLGEVLKIFKSGNEILELTYQLVILIQSFMAFIIGVLAAHQFKFNGAGAAIVGTSAMIGSGAVVYSNNSFMLKGIGDIINTSLVVIIACLIYMVLQNKLGSFELIILPVLVPIVSGGIGLITLPYIRKITQAIGNVIHSFTDLNPLLMSILISVAFSLLMVTPISLVAIATAISLNGLGSGAANLGIVAACVTFLFGSLRVNSIGVNAVLLIGAAKMMIPVYLKNLIISIPLTINGIITGIIAYVLQVKGTPLSAGFGYTGLVGPINAFNRMSGDPTMNIILLALGYFVIPFVSAFIVHELCKKFIPIYSNDIYKFEVPKQ
>NZ_CP040230.1|WP_138742481.1|1878817_1879546_-|ATP-binding-cassette-domain-containing-protein
MPVIKINNLNKVFGDNEVLKDINLEINQGEVVAIIGPSGSGKSTLLRCMNLLEVPTKGQVIFEGNDLTEKRTQVDKLRQKMGMVFQNFNLFPHKKVVDNIILAPKLLKKDNNDELHKEALSLLDKVGLKEKADVYPNQLSGGQKQRVAIARALAMHPDVILFDEPTSALDPEVVGDVLKVMKDLAKEGMTMVVVTHEMGFAKDVSDKVIFMTDGVVVESGTPVEIFEQPQHERTQNFLARVL
>NZ_CP040230.1|WP_001793998.1|1877539_1878682_-|tRNA-epoxyqueuosine(34)-reductase-QueG
MGGIRLDTKQLKQDIIDYAYTIGIDSIGFTTADPFDELKQKLEAYHANGYASGFEESDIALRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDMLAAFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVSIPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGNRLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRGKKPIQRNAILALAHFNEVDAIPELKKVATTDERPMIRATAYWAIGQILGEEARDFINANYDQEDAEVQNEMIKGLDTRRE
>NZ_CP040230.1|WP_000181394.1|1877064_1877535_-|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL
MTNHIVLYQPEIPANTGNIARTCAGTNTHLHLIKPLGFRTDDKMLKRAGLDYWEFVNITYHDSIEAFFEATNGEYYLLTKFGKKTYSDFDFSNHDKDFYFIFGKETTGLPDWVKEKYQDTALRIPMSEHIRSLNLSNTAALLIYEALRQQDFPGLN
>NZ_CP040230.1|WP_001251224.1|1876306_1876906_-|glucosamine-6-phosphate-isomerase
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGVPAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGKTSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
>NZ_CP040230.1|WP_000031108.1|1876129_1876282_-|hypothetical-protein
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
>NZ_CP040230.1|WP_000901018.1|1875191_1875587_-|hypothetical-protein
MLGKYWIQLLIATVIISLISIKAFPLAIGALYLPIIFKVIKLQLNLSKGLIDDVNAQTFIKSNQSGIVISVICCLLITGILYYTLDGFYASLTGVLGTLVALNPYTTIVSAILYILTAIATVEATKTKYRN
>NZ_CP040230.1|WP_000116238.1|1873610_1874996_-|class-II-fumarate-hydratase
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEFGDKVAQYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
>NZ_CP040230.1|WP_000669380.1|1872334_1873156_+|RluA-family-pseudouridine-synthase
MKFKIPENFNDLSLRDIFQQLKVPKKDLHHLNMSKDITINDKPARLMDKVHTGDDVFVPTIDEKSNYVPSYRYAQIKYEDDDMAIVMKPKGVKTHPNDLKESNTLMNHVIYTVDSDYVEPIHRLDQETVGLLIVAKNPLMKKILDRMLEDNDITRIYKANVKALLPLKPQTIDMPIGKDKFHSNKRRVSPTGQRAITHILTSKMIKETVCQLEIKLDTGRTHQIRVHLAEIGHPVIGDPLYGDSTLRQLELESYKIEFVHPLTKEVISVSLDD
>NZ_CP040230.1|WP_000437967.1|1871059_1872172_-|GAF-domain-containing-sensor-histidine-kinase
MEQRTRLALLKEIAEFLNEETEMYSMTQGALKYLIEGSNFTTGWIFFINSVGEHELVSHVALPQSLTADHCHYIKDGSCWCVKAFNQRRLMKASNIVNCSRINLASKAFPSQNDNITHHATVPLKSGQEQFGILNVASPNTEIYSDEDLELLESVAFQLGSAIKRIYLTDREKEAAKINERNRLARDLHDSVNQMLFSVKLTAHAAYGMSNESIAKQAFKTIEETSQNAVNEMRALIWQLKPVGLEQGLIHALTAYSKLMHIQLNVNVEGLIDLSNEIEENIYRALQECINNVKKHADTNKMDLTLKQMNDILYIDVIDYGQGFEIDNVQIASSHGINNIKQRVKLLRGKVTFHSQPTKGTQIQFTIPIK
>NZ_CP040230.1|WP_000110011.1|1891166_1891613_-|peroxide-responsive-transcriptional-repressor-PerR
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK
>NZ_CP040230.1|WP_000869465.1|1891709_1892660_-|2-hydroxyacid-dehydrogenase
MKVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLANLDILVGYDGGINEAFLRRCTNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIVINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKETLLIEVLKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY
>NZ_CP040230.1|WP_000939521.1|1892665_1893121_-|thioredoxin-dependent-thiol-peroxidase
MLQKGEQFPIFKLENQDGTVITNDTLKGKKAIIYFYPRDNTPTCTTEACDFRDNLEMFNDLDVAVYGISGDSKKKHQNFIEKHGLNFDLLVDEDFKLAKETGVYQLKKSFGKESMGIVRTTFIIDEQGKVLDVIEKVKVKTQIEELKNILG
>NZ_CP040230.1|WP_001011603.1|1893201_1894491_+|glutamate-1-semialdehyde-2,1-aminomutase
MNFSESERLQQLSNEYILGGVNSPSRSYKAVGGGAPVVMKEGHGAYLYDVDGNKFIDYLQAYGPIITGHAHPHITKAIQEQAAKGVLFGTPTELEIEFSKKLRDAIPSLEKIRFVNSGTEAVMTTIRVARAYTKRNKIIKFAGSYHGHSDLVLVAAGSGPSQLGSPDSAGVPESVAREVITVPFNDINAYKEAIEFWGDEIAAVLVEPIVGNFGMVMPQPGFLEEVNEISHSNGTLVIYDEVITAFRFHYGAAQDLLGVIPDLTAFGKIVGGGLPIGGYGGRQDIMEQVAPLGPAYQAGTMAGNPLSMKAGIALLEVLEQDGVYEKLDSLGQQLEEGLLKLIEKHNITATINRIYGSLTLYFTDEKVTHYDQVEHSDGEAFGKFFKLMLNQGINLAPSKFEAWFLTTEHTEEDIKQTLKAADYAFSQMK
>NZ_CP040230.1|WP_001807907.1|1894783_1895878_+|aromatic-acid-exporter-family-protein
MRLGARIFKTGIAIILAMSIASLLPDDVGLKALAGVSAVVAMQPSIYRSFKTVSDQALGNIIGAILSVTMVTIFSDNFIIMGVTVVVLIAILFKFNLAHVATLASVTALIIMGQHTGSFYITAFYRFVLVMIGVISSSLVNFVFLPPKFETKIYYNSLNISSDIFMWFKLVLNDTTEFNNIKQDSHNLKQRVEKLEKIYDYYSEERPITKKHIHQQNRKKILFREVVQTTRQAYEVLNKLSRYQNDLYLLNNNFLLQIKLDLDSLTAFHEQILASLSKKARYNVTHVDYELDNPQKKDLLSTFQHELINHPYQTEYSFANVMQIVAAIEEYRHHLEHLDRIRISFFTYHRSDADIEIVEEDFDL
>NZ_CP040230.1|WP_000597248.1|1896068_1897805_-|SAV1866-family-putative-multidrug-efflux-ABC-transporter
MIKRYLQFVKPYKYRIFATIIVGIIKFGIPMLIPLLIKYAIDGVINNHALTTDEKVHHLTIAIGIALFIFVIVRPPVEFIRQYLAQWTSNKILYDIRKKLYNHLQALSARFYANNQVGQVISRVINDVEQTKDFILTGLMNIWLDCITIIIALSIMFFLDVKLTLAALFIFPFYILTVYVFFGRLRKLTRERSQALAEVQGFLHERVQGISVVKSFAIEDNEAKNFDKKNTNFLIRALKHTRWNAYSFAAINTVTDIGPIIVIGVGAYLAISGSITVGTLAAFVGYLELLFGPLRRLVASFTTLTQSFASMDRVFQLIDEDYDIKNGVGAQPIEIKQGRIDIDHVSFQYNDNEAPILKDINLSIEKGETVAFVGMSGGGKSTLINLIPRFYDVTSGQILIDGHNIKDFLTGSLRNQIGLVQQDNILFSDTVKENILLGRPTATDEEVVEAAKMANAHDFIMNLPQGYDTEVGERGVKLSGGQKQRLSIARIFLNNPPILILDEATSALDLESESIIQEALDVLSKDRTTLIVAHRLSTITHADKIVVIENGHIVETGTHHELIAKQGAYEHLYSIQNL
>NZ_CP040230.1|WP_000251253.1|1898095_1898638_-|DUF402-domain-containing-protein
MVRESIPKEGENIKIQSYKHDGKIHRVWSETTILKGTDHVVIGGNDHTLVTESDGRTWITREPAIVYFHSEYWFNVICMFREDGIYYYCNLSSPFVCDEEALKYIDYDLDIKVYPNGKYHLLDEDEYEQHMNQMNYPHDIDIILRRNVDILQQWIEQKKGPFAPDFIKVWKERYKKIRQY
>NZ_CP040230.1|WP_000284749.1|1898940_1899978_-|A/G-specific-adenine-glycosylase
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFPTVEVLSQASEDEVLKYWEGLGYYSRARNFHTAIKEVHDKYEGLVPKDPDQFKALKGVGPYTQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQSTRKSYEQELLPYVTTEAGTFNQAMMELGALICTPKNPLCLFCPVQENCEAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNNQGQYLLQKRSEKLLHGMWQFPMFESEHARREMTEKIGHDIQPVETPIFELKHQFTHLTWKIKVYAVSGTINIERLPDDMIWFDLSDRDQYTFPVPMSKIYQFING
>NZ_CP040230.1|WP_000379101.1|1900129_1901107_+|metal-dependent-hydrolase
MDTATHIAIGVGLTALATQDPAMASTFGATATTLIVGSLIPDGDTVLKLKDNATYISHHRGITHSIPFTILWPILITFLIFTFFSGTNPFHVWMWAQLAVFLHVFVDIFNSYGTQALRPITNKWIQLSVINTFDPIIFTVLCIGIVLWVVGLHPFAVFFPIIALLIIYYMIRFKMRAVIKQQALKAIQQEHHPVKVFVAPTIKFMEWRVAIQTDAHDYVGKAYGRNVVFSDKVERQKLSTDSILWKVKGNKDIRTFLNFSSIYRWQTTTLADGSTEIRLIDLRYLKNDHYSFVAIAHVTNDNVIDHSYIGWVFTEDKLQRKLYAK
>NZ_CP040230.1|WP_014937047.1|1901210_1901441_+|hypothetical-protein
MNAFTKPNIYIVANKLPLMTRNIKISIGKQYLDYILIVSDSHRLIYTTGQLNIMKKYPPRLYYLLKHPVVYQFVSL

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Crispr_ID: NZ_CP040230_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_8

2094013-2094225

Orphan

Consensus_repeat	Method
TGATGTGCTGTTGTGGAAGCTTGGTGTCGTGCCATGCTACTTTGATG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP040230_8

>merge|NZ_CP040230|8|2094013-2094225|CRISPRCasFinder
TGACGTATTGTTGCGGGAACTTGGTGTCATGACATGTTACTTTGATGTGCTGGTACCACGATGCGTCTTGATGTAGTGCTATGATGTGCTGTTGTGGAAGCTTGGTGTCGTGCCATGCTACTTTGATGTGCTGTTGTGGGAGCTTGGTGTTGGTGCCATGTTACTTTGATGTGCTGTTGTGGAAGCTTGGTGTCATGCCATGCTACTTTGATG

>NZ_CP040230|8|8|2094013-2094225|CRISPRCasFinder
TGACGTATTGTTGCGGGAACTTGGTGTCATGACATGTTACTTTGATG	TGCTGGTACCACGATGCGTCTTGATGTAGTGCTA
TGATGTGCTGTTGTGGAAGCTTGGTGTCGTGCCATGCTACTTTGATG	TGCTGTTGTGGGAGCTTGGTGTTGGTGCCATGTTACTT
TGATGTGCTGTTGTGGAAGCTTGGTGTCATGCCATGCTACTTTGATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000751995.1\|2100495_2101191_-\|lytic-transglycosylase-SceD	unknown	unknown	gnl\|CDD\|369056
NZ_CP040230.1\|WP_000483161.1\|2097178_2097820_-\|thiamine-phosphate-synthase	unknown	unknown	gnl\|CDD\|234590
NZ_CP040230.1\|WP_000594965.1\|2098596_2099427_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
NZ_CP040230.1\|WP_000396068.1\|2099419_2100109_-\|thiaminase-II	unknown	unknown	gnl\|CDD\|213919
NZ_CP040230.1\|WP_000932694.1\|2101579_2101975_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|366099
NZ_CP040230.1\|WP_001178939.1\|2084614_2086135_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP040230.1\|WP_000611457.1\|2086650_2088006_-\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	unknown	unknown	gnl\|CDD\|223841
NZ_CP040230.1\|WP_000828354.1\|2090874_2091012_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000159641.1\|2088020_2089091_-\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234993
NZ_CP040230.1\|WP_001109939.1\|2089408_2090611_+\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP040230.1\|WP_001825748.1\|2094258_2094579_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000571550.1\|2091819_2093304_+\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|211988
NZ_CP040230.1\|WP_001108486.1\|2097821_2098613_-\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
NZ_CP040230.1\|WP_001187614.1\|2093331_2093979_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_CP040230.1\|WP_000138932.1\|2091360_2091654_-\|copper-sensing-transcriptional-repressor-CsoR	unknown	unknown	gnl\|CDD\|197387
NZ_CP040230.1\|WP_000725800.1\|2096220_2097093_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|235040
NZ_CP040230.1\|WP_001789631.1\|2102105_2102609_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379494
NZ_CP040230.1\|WP_000447678.1\|2102665_2103106_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	unknown	unknown	gnl\|CDD\|234568
NZ_CP040230.1\|WP_001190840.1\|2083566_2084262_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP040230.1\|WP_000581792.1\|2091139_2091349_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|238219

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000751995.1\|2100495_2101191_-\|lytic-transglycosylase-SceD	gnl\|CDD\|369056	pfam06737, Transglycosylas, Transglycosylase-like domain. This family of proteins are very likely to act as transglycosylase enzymes related to pfam00062 and pfam01464. These other families are weakly matched by this family, and include the known active site residues.	6.44668e-24
NZ_CP040230.1\|WP_000483161.1\|2097178_2097820_-\|thiamine-phosphate-synthase	gnl\|CDD\|234590	PRK00043, thiE, thiamine phosphate synthase.	5.71532e-89
NZ_CP040230.1\|WP_000594965.1\|2098596_2099427_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	1.38659e-148
NZ_CP040230.1\|WP_000396068.1\|2099419_2100109_-\|thiaminase-II	gnl\|CDD\|213919	TIGR04306, salvage_TenA, thiaminase II. The TenA protein of Bacillus subtilis and Staphylococcus aurues, and the C-terminal region of trifunctional protein Thi20p from Saccharomyces cerevisiae, perform cleavages on thiamine and related compounds to produce 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), a substrate a salvage pathway for thiamine biosynthesis. The gene symbol tenA, for Transcription ENhancement A, reflects a misleading early characterization as a regulatory protein. This family is related to PqqC from the PQQ biosynthesis system (see TIGR02111), heme oxygenase (pfam01126), and CADD (Chlamydia protein Associating with Death Domains), a putative folate metabolism enzyme (see TIGR04305).	1.05378e-100
NZ_CP040230.1\|WP_000932694.1\|2101579_2101975_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|366099	pfam00436, SSB, Single-strand binding protein family. This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.	9.06157e-32
NZ_CP040230.1\|WP_001178939.1\|2084614_2086135_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	7.40342e-159
NZ_CP040230.1\|WP_000611457.1\|2086650_2088006_-\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	gnl\|CDD\|223841	COG0770, MurF, UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane].	0
NZ_CP040230.1\|WP_000159641.1\|2088020_2089091_-\|D-alanine--D-alanine-ligase	gnl\|CDD\|234993	PRK01966, ddl, D-alanine--D-alanine ligase.	0
NZ_CP040230.1\|WP_001109939.1\|2089408_2090611_+\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	3.51677e-108
NZ_CP040230.1\|WP_000571550.1\|2091819_2093304_+\|cardiolipin-synthase	gnl\|CDD\|211988	TIGR04265, bac_cardiolipin, cardiolipin synthase. This model is based on experimentally characterized bacterial cardiolipin synthases (cls) from E. coli, Staphylococcus aureus (two), and Bacillus pseudofirmus OF4. This model describes just one of several homologous but non-orthologous forms of cls. The cutoff score is set arbitrarily high to avoid false-positives. Note that there are two enzymatic activites called cardiolipin synthase. This model represents type 1, which does not rely on a CDP-linked donor, but instead does a reversible transfer of a phosphatidyl group from one phosphatidylglycerol molecule to another.	0
NZ_CP040230.1\|WP_001108486.1\|2097821_2098613_-\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	7.69146e-123
NZ_CP040230.1\|WP_001187614.1\|2093331_2093979_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.00474e-42
NZ_CP040230.1\|WP_000138932.1\|2091360_2091654_-\|copper-sensing-transcriptional-repressor-CsoR	gnl\|CDD\|197387	cd10152, SaCsoR-like_DUF156, Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Staphylococcus aureus CsoR (SaCsoR). SaCsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis; it represses a genetically unlinked copA-copZ operon. copA encodes a copper efflux P-type ATPase, and copZ, a copper chaperone. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Bacillus subtilis CsoR, and Thermus thermophilus CsoR. The latter three proteins do not belong to this family. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	8.02331e-35
NZ_CP040230.1\|WP_000725800.1\|2096220_2097093_-\|membrane-protein-insertase-YidC	gnl\|CDD\|235040	PRK02463, PRK02463, OxaA-like protein precursor; Provisional.	7.06711e-64
NZ_CP040230.1\|WP_001789631.1\|2102105_2102609_+\|hypothetical-protein	gnl\|CDD\|379494	pfam14183, YwpF, YwpF-like protein. The YwpF-like protein family includes the B. subtilis YwpF protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 167 amino acids in length. There is a conserved IIN sequence motif.	5.66466e-57
NZ_CP040230.1\|WP_000447678.1\|2102665_2103106_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	gnl\|CDD\|234568	PRK00006, fabZ, 3-hydroxyacyl-ACP dehydratase FabZ.	8.27669e-92
NZ_CP040230.1\|WP_001190840.1\|2083566_2084262_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.28552e-68
NZ_CP040230.1\|WP_000581792.1\|2091139_2091349_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	0.000383249

>NZ_CP040230.1|WP_001187614.1|2093331_2093979_+|HD-domain-containing-protein
MQQSDIISAAKKYMESIHQNDYTGHDIAHVYRVTALAKSIAENEGVNDTLVIELACLLHDTVDEKVVDANKQYAELKSFLSSLSLSTEDQEHILFIINNMSYRNGKNDHVTLTLEGQIVRDADRLDAIGAIGVARTFQFAGHFGEPMWTEQMSLDKINDDLVEQLPPSAIKHFFEKLLKLESLMHTDTAKMIAKERHDFMMIYLKQFFTEWNYHD
>NZ_CP040230.1|WP_000571550.1|2091819_2093304_+|cardiolipin-synthase
MIELLSIALKHSNIILNSIFIGAFILNLLFAFTIIFMERRSANSIWAWLLVLVFLPLFGFILYLLLGRQIQRDQIFKIDKEDKKGLELIVDEQLAALKNENFSNSNYQIVKFKEMIQMLLYNNAAFLTTDNDLKIYTDGQEKFDDLIQDIRNATDYIHFQYYIIQNDELGRTILNELGKKAEQGVEVKILYDDMGSRGLRKKGLRPFRNKGGHAEAFFPSKLPLINLRMNNRNHRKIVVIDGQIGYVGGFNVGDEYLGKSKKFGYWRDTHLRIVGDAVNALQLRFILDWNSQATRDHISYDDRYFPDVNSGGTIGVQIASSGPDEEWEQIKYGYLKMISSAKKSIYIQSPYFIPDQAFLDSIKIAALGGVDVNIMIPNKPDHPFVFWATLKNAASLLDAGVKVFHYDNGFLHSKTLVIDDEIASVGTANMDHRSFTLNFEVNAFIYDQQIAKKLKQAFIDDLAVSSELTKARYANRSLWIKFKEGISQLLSPIL
>NZ_CP040230.1|WP_000138932.1|2091360_2091654_-|copper-sensing-transcriptional-repressor-CsoR
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQEEAMEELLVTFQKLIKD
>NZ_CP040230.1|WP_000581792.1|2091139_2091349_-|heavy-metal-associated-domain-containing-protein
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
>NZ_CP040230.1|WP_000828354.1|2090874_2091012_-|hypothetical-protein
MKRPEKIQNVVKLLSSLGVNIKKTKSRLDIINTLPASNKVSHELK
>NZ_CP040230.1|WP_001109939.1|2089408_2090611_+|rod-shape-determining-protein-RodA
MNYSSRQQPDKHWLRKVDWVLVATIAVLAIFSVLLINSAMGGGQYSANFGIRQIFYYILGAIFAGIIMFISPKKIKHYTYLLYFLICLLLIGLLVIPESPITPIINGAKSWYTFGPISIQPSEFMKIILILALARVVSRHNQFTFNKSFQSDLLLFFKIIGVSLVPSILILLQNDLGTTLVLAAIIAGVMLVSGITWRILAPIFITGIVGAMTVILGILYAPALIENLLGVQLYQMGRINSWLDPYTYSSGDGYHLTESLKAIGSGQLLGKGYNHGEVYIPENHTDFIFSVIGEELGFIGSVILILIFLFLIFHLIRLAAKIEDQFNKIFIVGFVTLLVFHILQNIGMTIQLLPITGIPLPFISYGGSALWSMMTGIGIVLSIYYHEPKRYVDLYHPKSN
>NZ_CP040230.1|WP_000159641.1|2088020_2089091_-|D-alanine--D-alanine-ligase
MTKENICIVFGGKSAEHEVSILTAQNVLNAIDKDKYHVDIIYITNDGDWRKQNNITTEIKSTDELHLENGEALEISQLLKESSSGQPYDAVFPLLHGPNGEDGTIQGLFEVLDVPYVGNGVLSAASSMDKLVMKQLFEHRGLPQLPYISFLRSEYEKYEHNILKLVNDKLNYPVFVKPANLGSSVGISKCNNEAELKEGIKEAFQFDRKLVIEQGVNAREIEVAVLGNDYPEATWPGEVVKDVAFYDYKSKYKDGKVQLQIPADLDEDVQLTLRNMALEAFKATDCSGLVRADFFVTEDNQIYINETNAMPGFTAFSMYPKLWENMGLSYPELITKLIELAKERHQDKQKNKYKID
>NZ_CP040230.1|WP_000611457.1|2086650_2088006_-|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase
MINVTLKQIQSWIPCEIEDQFLNQEINGVTIDSRAISKNMLFIPFKGENVDGHRFVSKALQDGAGAAFYQKGTPIDENVSGPIIWVEDTLTALQQLAQAYLRHVNPKVIAVTGSNGKTTTKDMIESVLHTEFKVKKTQGNYNNEIGLPLTILELDNDTEISILEMGMSGFHEIEFLSNLAQPDIAVITNIGESHMQDLGSREGIAKAKSEITIGLKDNGTFIYDGDEPLLKPHVKEVENAKCISIGVATDNALVCSVDDRDTTGISFTINNEHYDLPILGKHNMKNATIAIAVGHELGLTYNIIYQNLKNVSLTGMRMEQHTLENDITVINDAYNASPTSMRAAIDTLSTLTGRRILILGDVLELGENSKEMHIGVGNYLEEKHIDVLYTFGNEAKYIYDSGQQHVEKAQHFNSKDDMIEVLTSDLKAHDRVLVKGSRGMKLEEVVNALIS
>NZ_CP040230.1|WP_001178939.1|2084614_2086135_-|DEAD/DEAH-box-helicase
MQNFKELGISDNTVQSLESMGFKEPTPIQKDSIPYALQGIDILGQAQTGTGKTGAFGIPLIEKVVGKQGVQSLILAPTRELAMQVAEQLREFSRGQGVQVVTVFGGMPIERQIKALKKGPQIVVGTPGRVIDHLNRRTLKTDGIHTLILDEADEMMNMGFIDDMRFIMDKIPAVQRQTMLFSATMPKAIQALVQQFMKSPKIIKTMNNEMSDPQIEEFYTIVKELEKFDTFTNFLDVHQPELAIVFGRTKRRVDELTSALISKGYKAEGLHGDITQAKRLEVLKKFKNDQINILVATDVAARGLDISGVSHVYNFDIPQDTESYTHRIGRTGRAGKEGIAVTFVNPIEMDYIRQIEDANGRKMSALRPPHRKEVLQAREDDIKEKVENWMSKDSESRLKRISTELLNEYNDVDLVAALLQELVEANDEVEVQLTFEKPLSRKGRNGKPSGSRNRNSKRGNPKFDSKSKRSKGYSSKKKSTKKFDRKEKSSGGSRPMKGRTFADHQK
>NZ_CP040230.1|WP_001190840.1|2083566_2084262_+|response-regulator-transcription-factor
MQSKILIIEDDHAITHLLDVALTLDYYNVTTADNATQAHFKIQIDKPDVILLDLGLPDKDGLCLISEIRQHTDIPIIVISARQEEQTIIQALDNGANDYMTKPFNVDELRARIRVIERIAKSHQETNFVFTNGLLSIDFGSKSVVINNQEVHLTPNEFSLLELLSNHKGKVLTYEMILKRIYGYVNKTEMPSLRVHMTSLRQKLSQCHEDAKDIIKTHPRIGYQMLQWKEK
>NZ_CP040230.1|WP_001825748.1|2094258_2094579_+|hypothetical-protein
MIWRCGVMGGIARGIDAMPLQFYDMALGRCNVYYAVVTLLFHTVTCICELLWKCCDIYCYTDESLCQDDIAMMNSNSVINHFLHAEISLILFGSMSNWTDAFNIGS
>NZ_CP040230.1|WP_000725800.1|2096220_2097093_-|membrane-protein-insertase-YidC
MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGNNKKGKNTQVVSKKKKK
>NZ_CP040230.1|WP_000483161.1|2097178_2097820_-|thiamine-phosphate-synthase
MFNQSYLNVYFICGTSDVPSHRTIHEVLEAALKAGITLFQFREKGESALKGNDKLVLAKELQHLCHQYDVPFIVNDDVSLAKEINADGIHVGQDDAKVKEIAQYFTDKIIGLSISDLGEYAKSDLTHVDYIGVGPIYPTPSKNDAHTPVGPEMIATFKEMNPQLPIVAIGGINTSNVAPIVEAGANGISVISAISKSENIEKTVNRFKDFFNN
>NZ_CP040230.1|WP_001108486.1|2097821_2098613_-|hydroxyethylthiazole-kinase
MNYLNKIRIENPLTICYTNDVVKNFTANGLLSIGASPAMSEAPEEAEEFYKVAQALLINIGTLTAQNEQDIIAIAQTANEAGLPIVFDPVAVGASTYRKQFCKLLLKSAKVSVIKGNASEILALIDDTATMKGTDSDANLDAVAIAKKAYAIYKTAIVITGKEDVIVQGDKAIVLANGSPLLARVTGAGCLLGGVIAGFLFRETEPDIEALIEAVSVFNIAAEVAAENENCGGPGTFSPLLLDTLYHLNETTYQQRIRIQEVE
>NZ_CP040230.1|WP_000594965.1|2098596_2099427_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MIKPKIALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQNIHNLNHQWVDEQLDSVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDNDTKQNLQHTLLPLADVVTPNLPEAEEITGLTIDSEEKIMQAGRIFINEIGSKGVIVKGGHSNDTDIAKDYLFTKEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRPLFDAVQKAKKFISMSIQYTPEIGRGRGPVNHFAYLKKEGLDDELSK
>NZ_CP040230.1|WP_000396068.1|2099419_2100109_-|thiaminase-II
MEFSQKLYQAAKPIINDIYEDDFIQKMLLGNIQADALRHYLQADAAYLKEFTNLYALLIPKMNSMNDVKFLVEQIEFMVEGEVLAHDILAQIVGESYEEIIKTKVWPPSGDHYIKHMYFQAHSRENAIYTIAAMAPCPYIYAELAKRSQSDHKLNREKDTAKWFDFYSTEMDDIINVFESLMNKLAESMSDKELEQVKQVFLESCIHERRFFNMAMTLEQWEFGGKVND
>NZ_CP040230.1|WP_000751995.1|2100495_2101191_-|lytic-transglycosylase-SceD
MKKTLLASSLAVGLGIVAGNAGHEAHASEADLNKASLAQMAQSNDQTLNQKPIEAGAYNYTFDYEGFTYHFESDGTHFAWNYHATGANGADMSAQAPATNNVAPSADQANQVQSQEVEAPQNAQTQQPQASTSNNSQVTATPTESKASEGSSVNVNDHLKQIAQRESGGNIHAVNPTSGAAGKYQFLQSTWDSVAPAKYKGVSPANAPESVQDAAAVKLYNTGGAGHWVTA
>NZ_CP040230.1|WP_000932694.1|2101579_2101975_-|single-stranded-DNA-binding-protein
MLNKIVIVGRLTKDAQIFEKEDRKIATFCVATHRNYKDENGEIVCDYLFCKAFGKLASNIEKYTNQGTLVGITGQMRSRKYDKDGQTHFVTELYVETIKFMSPKSQNNEILSDSILDIDSQNIDNHDLLEI
>NZ_CP040230.1|WP_001789631.1|2102105_2102609_+|hypothetical-protein
MTLNLLNNSKIINIKLMGCGNMKTFKAVRFQIVNEHGRIIEYELEDGVIINKEESGTGWLLEIVISNEHYETFKEYQDNEQLLDIRVVITRPANDPALFESTVKSIKNFKTTMSIVFECHIYTLRQQYAESLLEQLIDDGLSGEELKKSFNRMMQSKPKLKDEKLEE
>NZ_CP040230.1|WP_000447678.1|2102665_2103106_-|3-hydroxyacyl-ACP-dehydratase-FabZ
METIFDYNQIKQIIPHRQPFLLIDKVVEYEEGQRCVAIKQVSGNEPFFQGHFPEYAVMPGVLITEALAQTGAVAILNSEENKGKIALFAGIDKCRFKRQVVPGDTLTLEVEITKIKGPIGKGNAKATVDGQLACSCELTFAIQDVK

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Crispr_ID: NZ_CP040230_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_9

2149644-2149794

Orphan

Consensus_repeat	Method
AACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

2 spacers

csa3,TnsE_C

The CRISPR arrays of NZ_CP040230_9

>merge|NZ_CP040230|9|2149644-2149794|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTAAACTTTAGTTGTAAGGGGCTCTTATGCAGTTGATGCATAGCATCCAACTGTGTTCCTCTATTTTTCAACTTTAGTTGTTAGGAGCTTCTTTCTA

>NZ_CP040230|9|9|2149644-2149794|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTACTTTTA
AACTTTAGTTGTAAGGGGCTCTTATGCA	GTTGATGCATAGCATCCAACTGTGTTCCTCTATTTTTC
AACTTTAGTTGTTAGGAGCTTCTTTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000003759.1\|2146966_2147287_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP040230.1\|WP_099184063.1\|2157012_2157303_-\|DUF3387-domain-containing-protein	unknown	unknown	gnl\|CDD\|378743
NZ_CP040230.1\|WP_000495673.1\|2148534_2149626_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001792291.1\|2150660_2150843_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000876896.1\|2154356_2155391_-\|toll/interleukin-1-receptor-domain-containing-protein	unknown	unknown	gnl\|CDD\|379328
NZ_CP040230.1\|WP_000019735.1\|2147288_2148269_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NZ_CP040230.1\|WP_000808818.1\|2144516_2144747_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000160304.1\|2140126_2140837_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP040230.1\|WP_001024099.1\|2146149_2146815_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP040230.1\|WP_001802298.1\|2150123_2150228_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000070865.1\|2140957_2141401_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP040230.1\|WP_000908191.1\|2152648_2153431_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP040230.1\|WP_001127960.1\|2144777_2145716_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP040230.1\|WP_000220902.1\|2151501_2151594_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000370942.1\|2151723_2152581_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP040230.1\|WP_000123402.1\|2142471_2143845_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
NZ_CP040230.1\|WP_000101715.1\|2153720_2154329_-\|TIR-domain-containing-protein	unknown	unknown	gnl\|CDD\|378100
NZ_CP040230.1\|WP_001792784.1\|2150907_2151066_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001123309.1\|2141600_2142014_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NZ_CP040230.1\|WP_001156920.1\|2157427_2157832_-\|hypothetical-protein	TnsE_C	TnsE	gnl\|CDD\|376049

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000003759.1\|2146966_2147287_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NZ_CP040230.1\|WP_099184063.1\|2157012_2157303_-\|DUF3387-domain-containing-protein	gnl\|CDD\|378743	pfam11867, DUF3387, Domain of unknown function (DUF3387). This domain is functionally uncharacterized. This domain is found in bacteria and archaea. This presumed domain is typically between 255 to 340 amino acids in length. This domain is found associated with pfam04851, pfam04313.	2.17206e-37
NZ_CP040230.1\|WP_000876896.1\|2154356_2155391_-\|toll/interleukin-1-receptor-domain-containing-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	2.54926e-06
NZ_CP040230.1\|WP_000019735.1\|2147288_2148269_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.75655e-109
NZ_CP040230.1\|WP_000160304.1\|2140126_2140837_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NZ_CP040230.1\|WP_001024099.1\|2146149_2146815_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.27205e-48
NZ_CP040230.1\|WP_000908191.1\|2152648_2153431_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.99209e-106
NZ_CP040230.1\|WP_000070865.1\|2140957_2141401_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
NZ_CP040230.1\|WP_001127960.1\|2144777_2145716_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NZ_CP040230.1\|WP_000370942.1\|2151723_2152581_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	6.61293e-60
NZ_CP040230.1\|WP_000123402.1\|2142471_2143845_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NZ_CP040230.1\|WP_000101715.1\|2153720_2154329_-\|TIR-domain-containing-protein	gnl\|CDD\|378100	pfam08937, DUF1863, MTH538 TIR-like domain (DUF1863). This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein. This domain is similar to the TIR domain.	4.16786e-19
NZ_CP040230.1\|WP_001156920.1\|2157427_2157832_-\|hypothetical-protein	gnl\|CDD\|376049	pfam18623, TnsE_C, TnsE C-terminal domain. The bacterial transposon Tn7 facilitates horizontal transfer by directing transposition into actively replicating DNA with the element-encoded protein TnsE. Structural analysis of the C-terminal domain of TnsE identified a central V-shaped loop that toggles between two distinct conformations. It is suggested that a conformational change within the C-terminal domain of TnsE underlies target site selection by regulating stable engagement of the target DNA while providing a signal for activating transposition.	5.43167e-08
NZ_CP040230.1\|WP_001123309.1\|2141600_2142014_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	5.06041e-44

>NZ_CP040230.1|WP_000495673.1|2148534_2149626_+|hypothetical-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPGDAYLKVIALLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLVGIAITTQSIIIIVVLLIKAIITWLLLIPVFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILYVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP040230.1|WP_000019735.1|2147288_2148269_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVNTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NZ_CP040230.1|WP_000003759.1|2146966_2147287_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NZ_CP040230.1|WP_001024099.1|2146149_2146815_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGDQDIKDALTQFENETD
>NZ_CP040230.1|WP_001127960.1|2144777_2145716_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NZ_CP040230.1|WP_000808818.1|2144516_2144747_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQTSASLKFSALLINVLPLCGTFVASN
>NZ_CP040230.1|WP_000123402.1|2142471_2143845_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NZ_CP040230.1|WP_001123309.1|2141600_2142014_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQQPEAANKNSVILQKGDRIYFESQAIIQLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NZ_CP040230.1|WP_000070865.1|2140957_2141401_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NZ_CP040230.1|WP_000160304.1|2140126_2140837_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NZ_CP040230.1|WP_001802298.1|2150123_2150228_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NZ_CP040230.1|WP_001792291.1|2150660_2150843_-|hypothetical-protein
MIIFRFKVNAFFPVKLCLMIRFCLESCCIFRRHLLITFHNIRSKFIMFKYISSKCIICTG
>NZ_CP040230.1|WP_001792784.1|2150907_2151066_+|hypothetical-protein
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>NZ_CP040230.1|WP_000220902.1|2151501_2151594_+|hypothetical-protein
MTYGSIVAILCALFAIFFIPYMEKKDKKKK
>NZ_CP040230.1|WP_000370942.1|2151723_2152581_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWLRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIEHFGINQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>NZ_CP040230.1|WP_000908191.1|2152648_2153431_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNAYEPATTGSVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP040230.1|WP_000101715.1|2153720_2154329_-|TIR-domain-containing-protein
MARKTFISYKYSEAKDLRDKIVESLGEDAKYYQGETSDSPDMSDRITEYIKKELKNKIYSTSVTIVVISPNMKESNWIDWEIEYSVKQMKRGDRTSSTNGVVGVVMKHNGDYSWLRNSVINSEGHTAIHTDNSYLYDIIVKNRFNQEPIEYTCDECKNIDALTGSFISLVEEDEFLGNPTKYIENAYEKSKKATNYNICRRK
>NZ_CP040230.1|WP_000876896.1|2154356_2155391_-|toll/interleukin-1-receptor-domain-containing-protein
MKYPIRQVAEVLPEKYTRYILLKEFQRLFPYQWNIIVERQQTYKEKAQHLYKVKKIKNRYNTKSAEEYFFSIPQVKYILSAGRMKKHKENYNASEIKIKKAALEKSRKNKNWKIEERLIKAKRYTQKVDPEYLNIYMKAYHKKDITTEEKLEILTELKKFDTENIVRFFRKLNDAEQNKMIRNLAFKYLQDYGHYVKLRKNFKGKKKVYQTERASLDTKKPEDLYNDLTNKNIQSQKVYDIFISHSTKDKKTVEDIIRVFNEQNKTCYCDWTMDQDYLKRKYVGEYTKQVLKARMEQSKMLVLLRTENSVQSDWVSFEIEYFENLKKPIYIVESLEELLEAFSD
>NZ_CP040230.1|WP_099184063.1|2157012_2157303_-|DUF3387-domain-containing-protein
MVMEENAFYDALASHDTAEHVLGDDTLKIIAHELTQSIKENMSIDWNLCESARAKMRVIVRRLLKKYGYPPEISKQAVETVIEQAELMSEQLAMEL
>NZ_CP040230.1|WP_001156920.1|2157427_2157832_-|hypothetical-protein
MQELEDYKEVQLIIIQMSSLPIGDGKRVFSYLEDGVTPRQYALATVSLFNGNEFKILEVERENCALSMLILSSTGLVNWNPLIDSLLLNLVNSSGTWVKESLEILERSNVIIQKAKHSKKEYAHRAKLLIHKML

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Crispr_ID: NZ_CP040230_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_10

2328054-2328139

Orphan

Consensus_repeat	Method
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP040230_10

>merge|NZ_CP040230|10|2328054-2328139|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACATAGAAGCTGGCGGAAAGTCAGCTTACAATAATGTGCAAGTTGG

>NZ_CP040230|10|10|2328054-2328139|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CGGGGCCCCAACATAGAAGCTGGCGG
AAAGTCAGCTTACAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000130460.1\|2334726_2335524_-\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|223559
NZ_CP040230.1\|WP_001826088.1\|2320798_2320993_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000684154.1\|2326558_2327683_-\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|168661
NZ_CP040230.1\|WP_000988993.1\|2321166_2322567_-\|Na+/H+-antiporter-NhaC	unknown	unknown	gnl\|CDD\|188097
NZ_CP040230.1\|WP_000684571.1\|2322661_2323744_-\|octopine-dehydrogenase	unknown	unknown	gnl\|CDD\|376763
NZ_CP040230.1\|WP_000426692.1\|2336625_2337363_-\|CPBP-family-intramembrane-metalloprotease-SdpB	unknown	unknown	gnl\|CDD\|376806
NZ_CP040230.1\|WP_000073196.1\|2338185_2339058_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP040230.1\|WP_000717395.1\|2319920_2320730_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP040230.1\|WP_016187165.1\|2333646_2334570_-\|putative-transcriptional-regulator	unknown	unknown	gnl\|CDD\|181811
NZ_CP040230.1\|WP_000737699.1\|2324650_2325151_+\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP040230.1\|WP_000206106.1\|2323991_2324414_+\|DUF4870-domain-containing-protein	unknown	unknown	gnl\|CDD\|225833
NZ_CP040230.1\|WP_000840813.1\|2329617_2330091_-\|DUF1641-domain-containing-protein	unknown	unknown	gnl\|CDD\|225283
NZ_CP040230.1\|WP_000921246.1\|2329089_2329323_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000131824.1\|2317355_2319311_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP040230.1\|WP_072460394.1\|2328291_2328930_-\|autolysin	unknown	unknown	gnl\|CDD\|226656
NZ_CP040230.1\|WP_000417008.1\|2325513_2326467_+\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240655
NZ_CP040230.1\|WP_000606724.1\|2337411_2337741_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001826090.1\|2327755_2327995_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001155267.1\|2330090_2333045_-\|formate-dehydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|225918
NZ_CP040230.1\|WP_001030125.1\|2335908_2336601_+\|YafY-family-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000130460.1\|2334726_2335524_-\|inositol-monophosphatase	gnl\|CDD\|223559	COG0483, SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism].	7.03254e-72
NZ_CP040230.1\|WP_000684154.1\|2326558_2327683_-\|NAD(P)-binding-protein	gnl\|CDD\|168661	PRK06753, PRK06753, hypothetical protein; Provisional.	0
NZ_CP040230.1\|WP_000988993.1\|2321166_2322567_-\|Na+/H+-antiporter-NhaC	gnl\|CDD\|188097	TIGR00931, Uncharacterized_Na+/H+_antiporter_HI_1107, Na+/H+ antiporter NhaC. A single member of the NhaC family, a protein from Bacillus firmus, has been functionally characterized.It is involved in pH homeostasis and sodium extrusion. Members of the NhaC family are found in both Gram-negative bacteria and Gram-positive bacteria. Intriguingly, archaeal homolog ArcD (just outside boundaries of family) has been identified as an arginine/ornithine antiporter. [Transport and binding proteins, Cations and iron carrying compounds].	3.69203e-115
NZ_CP040230.1\|WP_000684571.1\|2322661_2323744_-\|octopine-dehydrogenase	gnl\|CDD\|376763	pfam02317, Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain. This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	2.04121e-47
NZ_CP040230.1\|WP_000426692.1\|2336625_2337363_-\|CPBP-family-intramembrane-metalloprotease-SdpB	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.30887e-10
NZ_CP040230.1\|WP_000073196.1\|2338185_2339058_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	1.12128e-80
NZ_CP040230.1\|WP_000717395.1\|2319920_2320730_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	9.81396e-31
NZ_CP040230.1\|WP_000737699.1\|2324650_2325151_+\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	3.97694e-33
NZ_CP040230.1\|WP_000206106.1\|2323991_2324414_+\|DUF4870-domain-containing-protein	gnl\|CDD\|225833	COG3296, COG3296, Uncharacterized protein conserved in bacteria [Function unknown].	7.90586e-53
NZ_CP040230.1\|WP_000840813.1\|2329617_2330091_-\|DUF1641-domain-containing-protein	gnl\|CDD\|225283	COG2427, COG2427, Uncharacterized conserved protein [Function unknown].	1.05607e-29
NZ_CP040230.1\|WP_000131824.1\|2317355_2319311_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.66555e-14
NZ_CP040230.1\|WP_072460394.1\|2328291_2328930_-\|autolysin	gnl\|CDD\|226656	COG4193, LytD, Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism].	8.08552e-103
NZ_CP040230.1\|WP_000417008.1\|2325513_2326467_+\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240655	cd12178, 2-Hacid_dh_13, Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	0
NZ_CP040230.1\|WP_016187165.1\|2333646_2334570_-\|putative-transcriptional-regulator	gnl\|CDD\|181811	PRK09379, PRK09379, LytR family transcriptional regulator.	9.43081e-99
NZ_CP040230.1\|WP_001155267.1\|2330090_2333045_-\|formate-dehydrogenase-subunit-alpha	gnl\|CDD\|225918	COG3383, COG3383, Uncharacterized anaerobic dehydrogenase [General function prediction only].	0
NZ_CP040230.1\|WP_001030125.1\|2335908_2336601_+\|YafY-family-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	3.1353e-57

>NZ_CP040230.1|WP_001826090.1|2327755_2327995_-|hypothetical-protein
MKFSVLGPLTRVEKSLLQAHFHSVNYCQYNIIDPRTLIYVPSSHIIVTNVHYVNEYCCLNMHVIYNGADNTLKSLKMKR
>NZ_CP040230.1|WP_000684154.1|2326558_2327683_-|NAD(P)-binding-protein
MKIAIIGAGIGGLTAAALLQEQGHTIKVFEKNESVKEIGAGIGIGDNVLKKLGNHDLAKGIKNAGQILSTMTVLDDKDRPLTTVKLKSNTLNVTLPRQTLIDIIKSYVKDDAIFTNHEVTHIDNETDKVTIHFAEQESEAFDLCIGADGIHSKVRQSVNADSKVLYQGYTCFRGLIDDIDLKHPDCAKEYWGRKGRVGIVPLLNNQAYWFITINSKENNHKYSSFGKPHLQAYFNHYPNEVREILDKQSETGILLHNIYDLKPLKSFVYGRTILLGDAAHATTPNMGQGAGQAMEDAIVLVNCFNAYDFEKALQRYDKIRVKHTAKVIKRSRKIGKIAQYRSRLVVAVRNRIMKMMPNALAAGQTKFLYKSKEK
>NZ_CP040230.1|WP_000417008.1|2325513_2326467_+|2-hydroxyacid-dehydrogenase
MEKVYVAGAIPEVGLKLLQEHFEVEMYEGKGLVDKDTLIKGVKDATALISLLSTNVDKDVIDAGKDLKIIANYGAGFNNIDIEYAREKSIDVTNTPKASTNATADLTIGLVLAVARRIVEGDQLSRTTGFDGWAPLFFRGREVSGKTIGIIGLGEIGSAVARRARAFDMDVLYTGPNRKEEKEREIGAKYVDLDTLLKNADFITINAAYNPKMHHLIDTEQFKMMKSTAYLINASRGPIVHEQALVQALKNNEIEGAALDVYEFEPDITDDLKSLNNVVLTPHIGNATFEARDMMSKIVANAAISAVQGEKPQFVVN
>NZ_CP040230.1|WP_000737699.1|2324650_2325151_+|CHAP-domain-containing-protein
MKKLVTATTLTAGIGTALVGHAQHADAAENYTNYNNYNYNTTQTTTTTTTTTTTSSISHSGNLYTAGQCTWYVYDKVGGEIGSTWGNANNWAAAAQGAGFTVNHTPSKGAILQSSEGPFGHVAYVESVNSDGSVTISEMNYSGGPFSVSSRTISASEAGNYNYIHI
>NZ_CP040230.1|WP_000206106.1|2323991_2324414_+|DUF4870-domain-containing-protein
MTTEMNDVTNHQPNRKSNDENIMAMLIYLLSLFTSIIGPLIIWLLKKDESKLVDRAGKNYLNYTISYIIWSIVLVVITFIGVFLIATDIDFIIIIGFIITFIGILSIFAFSILSFVFTIIACVKYYNGQEYVIPLTIRFI
>NZ_CP040230.1|WP_000684571.1|2322661_2323744_-|octopine-dehydrogenase
MKIAIVGSGNGAVTAAVDMVSKGHDVKLYCRNQSISKFQNAIEKGGFDFNNEGEERFVKFTDISDDMEYVLKDAEIVQVIIPSSYIEYYADVMAEHVTDNQLIFFNMAAAMGSIRFMNVLEDRHIETKPQLAEANTLTYGTRVDFENAAVDLSLNVRRIFFSTYDRSCLNDCYDKVSSIYDHLVKEESLIKTNLENGNPEVHPGPTLLNVGRIDYAGEFALYKEGITKHTVRLLHAIELERLNLGRRLGFELSTAKESRIERGYLERDKEDEPLNRLFNTSPVFSQIPGPNHVESRYLTEDIAYGLVLWSSLGRVIDVPTPNIDAVIVIASTILERDFFEEGLTVESIGLDKLDLEKYLK
>NZ_CP040230.1|WP_000988993.1|2321166_2322567_-|Na+/H+-antiporter-NhaC
MMTRKPTFLESISTMIVMVIVVVTGFVFFDIPIQVLLIIASAYAAWIAKRVGLTWQDLEKGIAERLNTAMPAILIILAVGIIVGSWMFSGTVPALIYYGLDLLNPSYFLISAFFISAVTSVATGTAWGSASTAGIALISIGNQLSISPGMAAGAIIAGAVFGDKMSPLSDTTNLAALVTKVNIFKHIRSMMWTTIPASIIGLLVWFIAGFQFKGHSNDKQIQTLLSELAHIYQINIWVWVPLIVIIVCLLFKMATVPAMLISSFSAIIVGTFNHHFKMTDGFKAIFSGFNDSMIHQSHISSSVKSLLEQGGMMSMTQILVTIFCGYAFAGIVEKAGCLEVLLTTISKGIHSVGSLICITVICCIALVFAAGVASIVIIMVGVLMKDLFEKYQVSRSVLSRTLEDSSTMVLPLIPWGTSGIYYTNQLHVSVGEFFIWTVPCYLCAIIAIIYGFTGIGIKKSSNSRLT
>NZ_CP040230.1|WP_001826088.1|2320798_2320993_-|hypothetical-protein
MTKLIENLKASIFVSTLTKNLSMYSRFDAPKFGCVNGCMLFILYYRVNRIGENRSFEISTNPIF
>NZ_CP040230.1|WP_000717395.1|2319920_2320730_+|CHAP-domain-containing-protein
MKKIATATIATAGFATIAIASGNQAHASEQDNYGYNPNDPTSYSYTYTIDAQGNYHYTWKGNWHPSQLNQDNGYYSYYYYNGYNNYSYNNYNNGYSYNNYSRYNNYSNNNQSYNYNNYNSYNTNSYRTGGLGASYSTSSNNVQVTTTMAPSSNGRSISSGYTSGRNLYTSGQCTYYVFDRVGGKIGSTWGNASNWANAAARAGYTVNNTPKAGAIMQTTQGAYGHVAYVESVNSNGSVRVSEMNYGYGPGVVTSRTISASQAAGYNFIH
>NZ_CP040230.1|WP_000131824.1|2317355_2319311_-|helix-turn-helix-transcriptional-regulator
MTDNYSLHIFKSMKMSSVKEANLKIIYWLQGTGVVSINLQQYDVKRNDVTVIMLNDLYQIDGHDDSVCCVVEVSAKTFLKFMNANYMMRGKILTNEVASTLRILIKYLIYSKIKQQPYNANDKIINYMCVELMSLNTYDGSRHLVAEEVHDYLTNNHHKKINRKDVINQVSITNKALSDMFKATPYSNFIQYLNHIRLEHCLIDILTSKKPIEEIASSHGFNHYSRFIHLFKETYGDTPKLIRKRNSPTSHSINHSQLVEIDKNIIELFDDTNQSSSSMREIDIPFEPTKRSQMYQPKNIYIKGSNFYWMDYYTIKQIIQRLGVNPENLHIIVTIDTSNELSIEQITLLLQKIVNYNVNVVFRIKHEYKELLTSTERGKIEKLVATIFNMTFESNRCKIAFLINDLNTTAIQKLKRLIDNYIGVFELIYHLEPNELNTRYDKEIDHLIDYFILPLRQIEQVSIARSKIICDVDLINENNDLKEKITMSDINKVTELLTNYTKFRGLIMHMSIISEASKEINLTRLSIFIFIINILNQLRGIVIYQNDTMIVTKFKHEVQCVICLPAALLNENSDAIRLSCKGLQQFSHAKTKQIVLSIDKDNHTSENGVLVNDIMQQHSYWKANFIERNIYDHSLMVSSNSIVHLKYHLEI
>NZ_CP040230.1|WP_072460394.1|2328291_2328930_-|autolysin
MQQGKGIVQTKEEDGKFVEANNNEIAKAMTISHKDNDMKYMDITEKVPMSESEVNQLLKGKGILENRGKVFLEAQEKYEVNVIYLVSHALVETGNGKSELAKGIKDGKKRYYNFFGIGAFDSSAVRSGKSYAEKEQWTSPDKAILGGAKFIRNEYFENNQLNLYQMRWNPENPAQHQYASDIRWADKIAKLMDKSYKQFGIKKDDIRQTYYK
>NZ_CP040230.1|WP_000921246.1|2329089_2329323_-|hypothetical-protein
MLKTSAVISNTLLVIGLVCLFMMKLVLAITFFAVSLSISLVVFNMMFRDRTTMKVIVNASFLIVILAIVVAYFLLSK
>NZ_CP040230.1|WP_000840813.1|2329617_2330091_-|DUF1641-domain-containing-protein
MAERISSKIRRLEKSEEQIKLESLNEVTEAIAANKDSILKAIKLIKVLDDAKILDALNGAVRGRQVIINKFAVELNKDIYTGLLSNMASMVFLLGELNVSDLSDFLNKVNKGLHVANQASPNAKTSVRSLFGVLKDDDMNRSLTYMLNMLKGMSRED
>NZ_CP040230.1|WP_001155267.1|2330090_2333045_-|formate-dehydrogenase-subunit-alpha
MQEHLVVTLDGKDYLVEPGTNLLEFIKSQDTFVPSICYNESMGPIQTCDTCTVEIDGKIERSCSTVIDRPMTVNTVNNDVKDAQKEALDRILEKHMLYCTVCDYNNGDCEIHNTMDAWGLQHQTYEYKEKPYEKDYGPFYRYDPNQCILCGRCVEACQDIEVNETIRIDWDREHPRVIWDNDVPINESSCVSCGQCATVCPCNAMMEVNMEGNAGYMTDTEPGSLAAMIDLTKKAEPGYGPLFAISDSEAEMRKERIKKTKTVCTYCGVGCSFEVWTKDREILKVQPSHDSPANKIATCVKGKFSWGHINSDQRLTKPLVRKNGEFHEVEWDEALNVIADNFTSIKEKHGPDALSFISSSKATNEESYLMQKLARQVIGTNNVDNCSRYCQAPATKGLFRTVGHGGDSGSIEDLEKAAMSVLIGTNTAEAHPVIASRMKRAQKLFGQKIHVFDIRKHEMAERADRFYQPKPGTDLAWLSAVTKYIIDHDLHDKAFIEEWVEDFDEYYKSLETFTMAFAEEATGIPEAELIKFAEECAKAESVVICWAMGITQQDIGSDSSTAISNLLLVTGNYRRPGTGAYPLRGHNNVQGCSDMGSMPDKITGYQSIEADDIRAKFEKEYGVKLNPKAGKDNHEMVEGIHDGQIHSLYLYGEDTGIVDSNINFVQAAFEKLDFMVVQDEFLTFTATFADVVLPASPSLEKDGTFTNTERRIQRLYQALKPLGESKPDWKIFQAIANKLGFDWNYKHPSEIMDEIARLTPLYAGVSYERLEGFNSLQWPVHPDGTDEPILYLEGFNFDNGKAKLFPLSFDNYFKQDEVYDIHVNNGRLLEHFHEGNMTYQTPMLKYKVPRAFVEISPELAEDRGIHEGAEVKLISETGEAVLQVHVTDRVKGKEIYIPLNNDAMENGDLGAINLLTNSDVDQYTDTPSYKRTSCRLEVITKRGKSPLNPNNFRVNKKRHPQYSVQVQKKWERPDYVFPGNQVDK
>NZ_CP040230.1|WP_016187165.1|2333646_2334570_-|putative-transcriptional-regulator
MSLPKKIFLWVFGILVILAIVAVVYVAAKIFITGNKIHNPLDRNHSELRDKKVSLNDGDPFTIALFGVDSDADRKKKGGGERSDSIMILSINPKTKKTEIVSIPRDTRAEIVGRDTTEKIAHAYAYGGPNMAVKSLEKLMNVPIDHYATIDMDGLHNMIDSIGGVDVVSNDTFTVDGVRFTKGQQTHVNGDQALKFIRSRKEEGAGGDFGRQQRQQIVLEAMANKIASPSSITHFNSLMNEIQNNVKTDLTLGDLNTIRSNYKDANDTINKHQLSGQGGIQSDGLYYFIPSEQSKAESTKLLKDNLE
>NZ_CP040230.1|WP_000130460.1|2334726_2335524_-|inositol-monophosphatase
MTDKTLQQIDKLICSWLKQIDNVIPQLIMEMTTETKRHRFDLVTNVDKQIQQQFQQFLATHFQEHQLLAEEKSNEMITNEINHLWIMDPIDGTANLVKQQEDYCIILAYFYEGKPMLSYVYDYPHKKLYKAIRGEGAFCNGIKMEEPPSLKLEDAIISFNAQVMNLDTVQDLFDASFSYRLVGACGLDSMRVAKGQFGAHINTNPKPWDIAAQFLFAELLNLKMTTLDGKAIDHLKGAPFIISNKACHETVLKILNANGGYQKYR
>NZ_CP040230.1|WP_001030125.1|2335908_2336601_+|YafY-family-transcriptional-regulator
MNKAERQNLIITAIQQNKKMTALELAKYCNVSKRTILRDIDDLENQGVKIYAHYGKNGGYQIQQAQSKIALNLSETQLSALFLVLNESQSYSTLPYKSEINAIIKQCLSLPQTRLRKLLKRMDFYIKFDDTQHMTLPMLFSDILIYCTERNVMLVDHRVDDNIKAENVIFIGLLCKHGHWHAVIYDIAQDKTAELEIENIIDISYSFGKTIQTRDISIDNYHQFLNPIDS
>NZ_CP040230.1|WP_000426692.1|2336625_2337363_-|CPBP-family-intramembrane-metalloprotease-SdpB
MENEKKKYTFKDIAWRDLFIIPIIGVLSFALTIAAYIVPILFGYYEIDSNLIFVGTITQALAYTIGIGAFYLFHLKVMPSRLRAGFAYIKKYWLRLSITYIIALILIYTYEYMTQFLPKHLQYSETANELELNKMFEVPVFLPVAFLLIVIVGPIVEEIVFRHILIGELGKKFNFIAMSIVSVFLFAFIHVTDAKSPFEFGPYLILSIILVFTYIKSGRNLGSTIALHIANNFVSFVISVISIYA
>NZ_CP040230.1|WP_000606724.1|2337411_2337741_+|hypothetical-protein
MINETKYMRQQITNLIQIIDTIKYNTLMTDWNIQTHIYKFNQIVTNELNKFKGFETSYIINENQVFYYEIITLLNKRPLRQVDYGNKIQYLNFYHTELSNALFAIKFAH
>NZ_CP040230.1|WP_000073196.1|2338185_2339058_+|MurR/RpiR-family-transcriptional-regulator
MSNVLTEIDSQYPYMTKNEKKIAKFILNSPQKVIKMRSQDLASLLDISTSSVIRFSKKITDGGFHDLKINISKYVPKASSIYNVELMNNESTESLRTKLHTRTTRALNHANNELNDKTIDQICHCLKRSETIFIYGFGASFVVATDLYQKLSRIGLNIQLVQETHIFATLLATHNSNDSVILITNNGTQSEMQSMVKVIDDYHIPIITITSTRDNPVAQASNIVLTYGKTDENEMHMGATTSLFAQMFTIDILYYRYVALNYHASLDYITQSKMALDNYRKHLSNINFKH

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Crispr_ID: NZ_CP040230_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_11

2444472-2444566

Orphan

Consensus_repeat	Method
TTCTTCAAATTTATTTGTTAGAAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_11

>merge|NZ_CP040230|11|2444472-2444566|CRISPRCasFinder
TTCTTCAAATTTATTTGTTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTCGTCTTCTTCAAATTTATTTGTTAGAAAGGC

>NZ_CP040230|11|11|2444472-2444566|CRISPRCasFinder
TTCTTCAAATTTATTTGTTAGAAAGGC	TTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTCGTC
TTCTTCAAATTTATTTGTTAGAAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000819845.1\|2436288_2436651_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
NZ_CP040230.1\|WP_000792574.1\|2444958_2446269_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|288473
NZ_CP040230.1\|WP_000162807.1\|2435670_2436270_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
NZ_CP040230.1\|WP_000615466.1\|2438252_2438984_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP040230.1\|WP_000762708.1\|2442193_2442298_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000200954.1\|2450279_2450747_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
NZ_CP040230.1\|WP_001012240.1\|2436905_2438156_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067
NZ_CP040230.1\|WP_000286872.1\|2450757_2451450_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
NZ_CP040230.1\|WP_000971556.1\|2451460_2452576_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
NZ_CP040230.1\|WP_001056917.1\|2449250_2450228_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
NZ_CP040230.1\|WP_138742511.1\|2438980_2439700_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
NZ_CP040230.1\|WP_001807892.1\|2444744_2444864_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001110056.1\|2453562_2454921_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
NZ_CP040230.1\|WP_000019127.1\|2443464_2444331_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
NZ_CP040230.1\|WP_001125208.1\|2442451_2443138_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
NZ_CP040230.1\|WP_000594523.1\|2446804_2447734_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
NZ_CP040230.1\|WP_000825936.1\|2439680_2440460_-\|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|270429
NZ_CP040230.1\|WP_001046647.1\|2452553_2453561_-\|biotin-synthase-BioB	unknown	unknown	gnl\|CDD\|235755
NZ_CP040230.1\|WP_000038955.1\|2440580_2442020_-\|multidrug-efflux-MFS-transporter-MdeA	unknown	unknown	gnl\|CDD\|129794
NZ_CP040230.1\|WP_000916697.1\|2448301_2449249_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000819845.1\|2436288_2436651_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	4.12726e-31
NZ_CP040230.1\|WP_000792574.1\|2444958_2446269_+\|hypothetical-protein	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.53315e-25
NZ_CP040230.1\|WP_000162807.1\|2435670_2436270_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	3.11803e-30
NZ_CP040230.1\|WP_000916697.1\|2448301_2449249_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.12563e-91
NZ_CP040230.1\|WP_000286872.1\|2450757_2451450_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	8.32691e-130
NZ_CP040230.1\|WP_000200954.1\|2450279_2450747_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00118414
NZ_CP040230.1\|WP_001012240.1\|2436905_2438156_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
NZ_CP040230.1\|WP_000971556.1\|2451460_2452576_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	7.0088e-136
NZ_CP040230.1\|WP_001056917.1\|2449250_2450228_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	2.43039e-128
NZ_CP040230.1\|WP_138742511.1\|2438980_2439700_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	8.44183e-78
NZ_CP040230.1\|WP_000615466.1\|2438252_2438984_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.01718e-147
NZ_CP040230.1\|WP_001110056.1\|2453562_2454921_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
NZ_CP040230.1\|WP_000019127.1\|2443464_2444331_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.54055e-90
NZ_CP040230.1\|WP_001125208.1\|2442451_2443138_-\|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
NZ_CP040230.1\|WP_000594523.1\|2446804_2447734_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	3.62723e-97
NZ_CP040230.1\|WP_000825936.1\|2439680_2440460_-\|transporter-substrate-binding-domain-containing-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.4238e-99
NZ_CP040230.1\|WP_001046647.1\|2452553_2453561_-\|biotin-synthase-BioB	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
NZ_CP040230.1\|WP_000038955.1\|2440580_2442020_-\|multidrug-efflux-MFS-transporter-MdeA	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.17835e-92

>NZ_CP040230.1|WP_000019127.1|2443464_2444331_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNAPRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>NZ_CP040230.1|WP_001125208.1|2442451_2443138_-|2,3-diphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>NZ_CP040230.1|WP_000762708.1|2442193_2442298_+|putative-metal-homeostasis-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>NZ_CP040230.1|WP_000038955.1|2440580_2442020_-|multidrug-efflux-MFS-transporter-MdeA
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGIVLVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIEMMNQIKIDTMLHGYHAGFLFALLITVISFFCSFMLQGKKKEVDSHQ
>NZ_CP040230.1|WP_000825936.1|2439680_2440460_-|transporter-substrate-binding-domain-containing-protein
MKRLLFVVIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKAEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSKSAFAFSKKVDDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>NZ_CP040230.1|WP_138742511.1|2438980_2439700_-|ABC-transporter-permease-subunit
MFLNLNSEQLHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKVLRSIARVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYSSEIIRGGIISIPKGQTEAAYSIGMTYRQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>NZ_CP040230.1|WP_000615466.1|2438252_2438984_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVGKGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVFVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKAEAREKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAREVSNNIVFIHEGEIGEQGAPEEIFNNPKTEELKRFLNVINEE
>NZ_CP040230.1|WP_001012240.1|2436905_2438156_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKQNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEVLEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHINRYNFYGITGDFSESAEDYGVQQFKKGFNAHVEEYIGDFIKPIKPMLYKLQTYLKHKRR
>NZ_CP040230.1|WP_000819845.1|2436288_2436651_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYDFSDKRVSYKQGFDSRRYYQQHDADYHEENMTN
>NZ_CP040230.1|WP_000162807.1|2435670_2436270_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDNHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQKDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKGNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>NZ_CP040230.1|WP_001807892.1|2444744_2444864_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYEEMQYFANK
>NZ_CP040230.1|WP_000792574.1|2444958_2446269_+|hypothetical-protein
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAITKLQKNDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNTLSNLLSFWK
>NZ_CP040230.1|WP_000594523.1|2446804_2447734_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFTEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHEKGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>NZ_CP040230.1|WP_000916697.1|2448301_2449249_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGNDVEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKNTNHIKSMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFKNRNYTVKYEVNWKTHEIKVKGQN
>NZ_CP040230.1|WP_001056917.1|2449250_2450228_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MNMNKLVKSSVATSMALLLLSNTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKAAGNINSGYERPNPKDYDFSKIYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>NZ_CP040230.1|WP_000200954.1|2450279_2450747_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>NZ_CP040230.1|WP_000286872.1|2450757_2451450_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIDDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLNHYISFLESTPKQVIYETV
>NZ_CP040230.1|WP_000971556.1|2451460_2452576_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDQVDFESFMRKYSYHLSSSRLISGSSTVYEEIESMLADWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIPKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHAEQDIDRLFEILHQED
>NZ_CP040230.1|WP_001046647.1|2452553_2453561_-|biotin-synthase-BioB
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYGTCENKENKNDVSRAN
>NZ_CP040230.1|WP_001110056.1|2453562_2454921_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGLSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMAAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYNAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRKLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC

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Crispr_ID: NZ_CP040230_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_12

2504195-2504289

Orphan

Consensus_repeat	Method
AGGCTCTTATGCAGTTGGTGCGAAGCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_12

>merge|NZ_CP040230|12|2504195-2504289|CRISPRCasFinder
AGGCTCTTATGCAGTTGGTGCGAAGCAAGCAACTGTATTCCTCTAAAACTGTAATTTTAATTACTAGAGGCTCTTATGCAGTTGTTGCGAAGCAA

>NZ_CP040230|12|12|2504195-2504289|CRISPRCasFinder
AGGCTCTTATGCAGTTGGTGCGAAGCAA	GCAACTGTATTCCTCTAAAACTGTAATTTTAATTACTAG
AGGCTCTTATGCAGTTGTTGCGAAGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000675405.1\|2494750_2495944_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NZ_CP040230.1\|WP_000590515.1\|2495955_2496705_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224049
NZ_CP040230.1\|WP_000040594.1\|2501064_2502366_-\|staphylopine-dehydrogenase-CntM	unknown	unknown	gnl\|CDD\|226839
NZ_CP040230.1\|WP_000072470.1\|2493780_2494527_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	unknown
NZ_CP040230.1\|WP_001807941.1\|2509178_2509577_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NZ_CP040230.1\|WP_001124998.1\|2514323_2514743_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NZ_CP040230.1\|WP_000037506.1\|2509603_2510014_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NZ_CP040230.1\|WP_001229077.1\|2499323_2500922_-\|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA	unknown	unknown	gnl\|CDD\|274072
NZ_CP040230.1\|WP_000824952.1\|2505582_2506401_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181491
NZ_CP040230.1\|WP_000173877.1\|2496697_2497513_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP040230.1\|WP_001146763.1\|2508284_2508707_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP040230.1\|WP_001081687.1\|2503187_2504009_-\|histidine-racemase-CntK	unknown	unknown	gnl\|CDD\|223331
NZ_CP040230.1\|WP_001084931.1\|2510918_2512127_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153341
NZ_CP040230.1\|WP_000905462.1\|2510468_2510852_-\|DUF1433-domain-containing-protein	unknown	unknown	gnl\|CDD\|284628
NZ_CP040230.1\|WP_000202032.1\|2506634_2508173_+\|AbgT-family-transporter	unknown	unknown	gnl\|CDD\|367668
NZ_CP040230.1\|WP_000505991.1\|2512132_2512447_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000910577.1\|2504957_2505320_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000472235.1\|2498375_2499311_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP040230.1\|WP_000584764.1\|2497509_2498379_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP040230.1\|WP_001058850.1\|2502358_2503177_-\|D-histidine-(S)-2-aminobutanoyltransferase-CntL	unknown	unknown	gnl\|CDD\|176222

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000675405.1\|2494750_2495944_-\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.44638e-79
NZ_CP040230.1\|WP_000040594.1\|2501064_2502366_-\|staphylopine-dehydrogenase-CntM	gnl\|CDD\|226839	COG4408, COG4408, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP040230.1\|WP_001807941.1\|2509178_2509577_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	3.40871e-34
NZ_CP040230.1\|WP_001124998.1\|2514323_2514743_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	1.11006e-27
NZ_CP040230.1\|WP_000037506.1\|2509603_2510014_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	5.68109e-39
NZ_CP040230.1\|WP_001229077.1\|2499323_2500922_-\|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA	gnl\|CDD\|274072	TIGR02294, Nickel-binding_periplasmic_protein, nickel ABC transporter, nickel/metallophore periplasmic binding protein. Members of this family are periplasmic nickel-binding proteins of nickel ABC transporters. Most appear to be lipoproteins. This protein was previously (circa 2003) thought to mediate binding to nickel through water molecules, but is now thought to involve a chelating organic molecule, perhaps butane-1,2,4-tricarboxylate, acting as a metallophore. [Transport and binding proteins, Cations and iron carrying compounds].	0
NZ_CP040230.1\|WP_000824952.1\|2505582_2506401_-\|SDR-family-oxidoreductase	gnl\|CDD\|181491	PRK08589, PRK08589, SDR family oxidoreductase.	0
NZ_CP040230.1\|WP_000173877.1\|2496697_2497513_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	3.80608e-117
NZ_CP040230.1\|WP_001146763.1\|2508284_2508707_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	2.83513e-29
NZ_CP040230.1\|WP_001081687.1\|2503187_2504009_-\|histidine-racemase-CntK	gnl\|CDD\|223331	COG0253, DapF, Diaminopimelate epimerase [Amino acid transport and metabolism].	2.70571e-73
NZ_CP040230.1\|WP_001084931.1\|2510918_2512127_+\|hypothetical-protein	gnl\|CDD\|153341	cd07657, F-BAR_Fes_Fer, The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases. F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Fes (feline sarcoma), also called Fps (Fujinami poultry sarcoma), and Fer (Fes related) are cytoplasmic (or nonreceptor) tyrosine kinases that play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Although Fes and Fer show redundancy in their biological functions, they show differences in their expression patterns. Fer is ubiquitously expressed while Fes is expressed predominantly in myeloid and endothelial cells. Fes and Fer contain an N-terminal F-BAR domain, an SH2 domain, and a C-terminal catalytic kinase domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. The F-BAR domain of Fes is critical in its role in microtubule nucleation and bundling.	0.00836241
NZ_CP040230.1\|WP_000905462.1\|2510468_2510852_-\|DUF1433-domain-containing-protein	gnl\|CDD\|284628	pfam07252, DUF1433, Protein of unknown function (DUF1433). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	1.96173e-37
NZ_CP040230.1\|WP_000202032.1\|2506634_2508173_+\|AbgT-family-transporter	gnl\|CDD\|367668	pfam03806, ABG_transport, AbgT putative transporter family.	0
NZ_CP040230.1\|WP_000590515.1\|2495955_2496705_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224049	COG1124, DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.955e-107
NZ_CP040230.1\|WP_000472235.1\|2498375_2499311_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.46808e-99
NZ_CP040230.1\|WP_000584764.1\|2497509_2498379_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.45335e-84
NZ_CP040230.1\|WP_001058850.1\|2502358_2503177_-\|D-histidine-(S)-2-aminobutanoyltransferase-CntL	gnl\|CDD\|176222	cd08261, Zn_ADH7, Alcohol dehydrogenases of the MDR family. This group contains members identified as related to zinc-dependent alcohol dehydrogenase and other members of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group includes various activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	0.000104575

>NZ_CP040230.1|WP_001081687.1|2503187_2504009_-|histidine-racemase-CntK
MNRQVIEFSKYNPSGNMTILVHSKHDASEYASIANQLMAATHVCCEQVGFIESTQNDDGNDFHLVMSGNEFCGNATMSYIHHLQESHLLKDQQFKVKVSGCSDLVQCAIHDCQYYEVQMPQAHRVVPTTINMGNHSWKAIEIIYETYVHYVIPVKQVTTEIQHLVETYVRKQQWNHKYKTVGMMLFDEQRQFLQPLIYIPEIQSLIWENSCGSGTASIGVFNNYQRNDACKDFTVHQPGGSILVTSKRCHQLGYQTSIKGQVTTVATGKAYIE
>NZ_CP040230.1|WP_001058850.1|2502358_2503177_-|D-histidine-(S)-2-aminobutanoyltransferase-CntL
MNNFNNEIKLILQQYLEKFEAHYERVLQDDQYIEALETLMDDYSEFILNPIYEQQFNAWRDVEEKAQLINSLQYITAQCVKQVEVIRARRLLDGQASTTGYFDNIEHCIDEEFGQCSIASNDKLLLVGSGAYPMTLIQVAKETGASVIGIDIDPQAVDLGRRIVNVLAPNEDITITDQKVSELKDIKDVTHIIFSSTIPLKYSILEELYDLTNENVVVAMRFGDGIKAIFNYPSQETAEDKWQCVNKHMRPQQIFDIALYKKAAIKVGITDV
>NZ_CP040230.1|WP_000040594.1|2501064_2502366_-|staphylopine-dehydrogenase-CntM
MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNEAHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTYSNSTMCQRISVLAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVYKLFPEGPITMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEHFEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPSEDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQHLSSQFNTNLFEEDKALVTKFLEINRTLS
>NZ_CP040230.1|WP_001229077.1|2499323_2500922_-|staphylopine-dependent-metal-ABC-transporter-substrate-binding-protein-CntA
MRKLTKMSAMLLASGLILTGCGGNKGLEEKKENKQLTYTTVKDIGDMNPHVYGGSMSAESMIYEPLVRNTKDGIKPLLAKKWDVSEDGKTYTFHLRDDVKFHDGTPFDADAVKKNIDAVQENKKLHSWLKISTLIDNVKVKDKYTVELNLKEAYQPALAELAMPRPYVFVSPKDFKNGTTKDGVKKFDGTGPFKLGEHKKDESADFNKNDQYWGEKSKLNKVQAKVMPAGETAFLSMKKGETNFAFTDDRGTDSLDKDSLKQLKDTGDYQVKRSQPMNTKMLVVNSGKKDNAVSDKTVRQAIGHMVNRDKIAKEILDGQEKPATQLFAKNVTDINFDMPTRKYDLKKAESLLDEAGWKKGKDSDVRQKDGKNLEMAMYYDKGSSSQKEQAEYLQAEFKKMGIKLNINGETSDKIAERRTSGDYDLMFNQTWGLLYDPQSTIAAFKAKNGYESATSGIENKDKIYNSIDDAFKIQNGKERSDAYKNILKQIDDEGIFIPISHGSMTVVAPKDLEKVSFTQSQYELPFNEMQYK
>NZ_CP040230.1|WP_000472235.1|2498375_2499311_-|ABC-transporter-permease
MFKFILKRIALMFPLMIVVSFMTFLLTYITNENPAVTILHAQGTPNVTPELIAETNEKYGFNDPLLIQYKNWLLEAMQFNFGTSYITGDPVAERIGPAFMNTLKLTIISSVMVMITSIILGVVSALKRGKFTDRAIRSVAFFLTALPSYWIASILIIYVSVKLNILPTSGLTGPESYILPVIVITIAYAGIYFRNVRRSMVEQLNEDYVLYLRASGVKSITLMLHVLRNALQVAVSIFCMSIPMIMGGLVVIEYIFAWPGLGQLSLKAILEHDFPVIQAYVLIVAVLFIVFNTLADIINALLNPRLREGAR
>NZ_CP040230.1|WP_000584764.1|2497509_2498379_-|ABC-transporter-permease
MIILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGMSFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDPRISSKDKLRSVKKGVMQS
>NZ_CP040230.1|WP_000173877.1|2496697_2497513_-|ABC-transporter-ATP-binding-protein
MTLLTVKHLTITDTWTDQPLVSDVNFTLTKGETLGVIGESGSGKSITCKSIVGLNPERLRVTGDITFDGTSMLSLSESQLKKYRGKDIAMVMQQGSRAFDPSTTVGKQMFETMKVHTSMSTQEIEKTLIEYMDYLSLKDPKRILKSYPYMLSGGMLQRLMIALALALKPKLIIADEPTTALDTITQYDVLEAFIDIKKHFDCAMIFISHDLTVINKIADRVVVMKNGQLIEHGTRESVLHHPEHVYTKYLLSTKKKINDHFKHVMRGDVCD
>NZ_CP040230.1|WP_000590515.1|2495955_2496705_-|ABC-transporter-ATP-binding-protein
MIKIKDVEKSYQSAHVFKRRRTPIVKGVSFECPIGATIAIIGESGSGKSTLSRMILGIEKPDKGCVTLNDQPMHKKKVRRHQIGAVFQDYTSSLHPFQTVREILFEVMCQCDGQPKDVMEVQAITLLEEVGLSKAYMDKYPNMLSGGEAQRVAIARAICINPKYILFDEAISSLDMSIQTQILDLLIHLRETRQLSYIFITHDIQAATYLCDQLIIFKNGKIEEQIPTSALHKSDNAYTRELIEKQLSF
>NZ_CP040230.1|WP_000675405.1|2494750_2495944_-|MFS-transporter
MKGAMAWPFLRLYILTLMFFSANAILNVFIPLRGHDLGATNTVIGIVMGAYMLTAMVFRPWAGQIIARVGPIKVLRIILIINAIALIIYGFTGLEGYFVARVMQGVCTAFFSMSLQLGIIDALPEEHRSEGVSLYSLFSTIPNLIGPLVAVGIWNANNISLFAIVIIFIALTTTFFGYRVTFAEQEPDTSDKIEKMPFNAVTVFAQFFKNKELLNSGIIMIVASIVFGAVSTFVPLYTVSLGFANAGIFLTIQAIAVVVARFYLRKYIPSDGMWHPKYMVSVLSLLVIASFIVAFGPQVGAIIFYGSAILIGMTQAMVYPTLTSYLSFVLPKVGRNMLLGLFIACADLGISLGGALMGPISDLVGFKWMYLICGMLVIVIMIMSLLKKPTPRPANSL
>NZ_CP040230.1|WP_000072470.1|2493780_2494527_+|CPBP-family-intramembrane-metalloprotease
MSNTNKHYIEEYATEQSRFFKRDIGFIFLYIFLVNILPIIIVFLTFGLVAVFTQQAPWGFSFPISMNISYLLAVIISLAIFRLMHEDAFIPMIRSQIVASAKYKWHILISFTLSIVLFLLLNHFDIFALNVDSFTVFDIYPLIREYGSISLIAIFSLTIILNTLICQLIFRHILIQELSRLIPLKITIVLSVILETLYYYPYINTWWEFIPALILASSATYLYLKSNRNFMVSYFYQLAVILVLHIFM
>NZ_CP040230.1|WP_000910577.1|2504957_2505320_-|hypothetical-protein
MLKEKESFRLLYQAIREIADKIGDNQLETNSVSLLLLDFDFEHEVFDELYLAILKYLNTVSIENISHSELLNLIENTIPEDREINTFVKNKIIIGFANNYFPELQVLANEIKSDMASSLK
>NZ_CP040230.1|WP_000824952.1|2505582_2506401_-|SDR-family-oxidoreductase
MKRLENKVAVVTGASTGIGQASAIALAQEGAYVLAVDIAEAVSETVDKIKSNGDNAKAYTVDISDEQQVVDFVSDIKEQFGRIDVLFNNAGVDNAAGRIHEYPTDVYDKIMNVDMRGTFLMTKMMLPLMMTKGGSIVNTSSFSGQAADLYRSGYNAAKGAVINFTKSIAIEYGRDGIRANAIAPGTIETPLVDKLTGTSEDKEGKTFRENQKWMTPLGRLGKPEEVGKLVVFLASDESSFITGETIRIDGGVMAYTWPGEMLSDDSWKRTLE
>NZ_CP040230.1|WP_000202032.1|2506634_2508173_+|AbgT-family-transporter
MTSKHQQKGSIVNRFLNSVEKIGNKLPDPSVLFFLMCVGLAIMTWVISLFNVSVKHPGTHQTIYIKNIISHDGFTMIMNDTIKNFSEFPALGLVLAVMIGIGVAEKTGYFDKLMISVVNRAPRFLILPTIILIGILGSTAGDAATIILPPLAAMLFIKIGYHPIAGLTMAYASAVGGFAANIVVGMQDALVYSFTEPATRIVSDSIKTNVAMNWYFIAASVIVLLPTILLVTTKLIIPRLGQYDDRLMHDDHEETSSHITDKEAHALKWANISFIVTIILLIITAIPEHSFLRNAKTGSLLDDAPLINGVGLIILVVFLVPGLVYGILSKEIKNTKDLGKMFGDAVGSMGTFIVIVFFAAQLLAYLKWSNLGIIAAVKGAKLLEHQNGIVLILGIIVLSAMVNMLIGSASAKWGILGPIFVPMLILIGFHPAFTQVIYRVGDSITNPITPMMPYLPLLLTYAQKYDKRMKLGALLSSLMPYSIALSIVWTVFVIIWFLLGIPVGPGGPIFVK
>NZ_CP040230.1|WP_001146763.1|2508284_2508707_-|carboxymuconolactone-decarboxylase-family-protein
MPYNYKKQNGELMSVMSQGEKFIHQSPVNDELSALIKLLISKINGCHYCVDIHKKELKELGVTQMKIDEVLSFRHLDLFTDQEKVTLEFAEMLNSIKDFKKFEIIDRLKSFYDEEQIIDLVFVVNQINGWNRLNIISDRL
>NZ_CP040230.1|WP_001807941.1|2509178_2509577_-|DUF1433-domain-containing-protein
MNKKHVFIIIGVILCIRIVATVIYLKVKYDEKEKQKAIYYKEQQERITLYLKHNTKEPNTIKSVHFTSLKTGPMGDAVIEGYINENKKADFVAYGSPEHNYQFGGDMIESEKLSELLKPAQELKSQKKSKKN
>NZ_CP040230.1|WP_000037506.1|2509603_2510014_-|DUF1433-domain-containing-protein
MSKKHVFIIIGVILCICIVVTAMHLKMKYDEKEKRKAIYYKEQQARITLYLKHNTKEPNTIKSVHFTNLETSPMGSAVIEGYINENKKDNFTAYATPEHNYQFGGAMIKSEGVDKLLKPAHERKSPDDIKKELNKK
>NZ_CP040230.1|WP_000905462.1|2510468_2510852_-|DUF1433-domain-containing-protein
MLIILIIIVCVYLKIKIDEKEKQKAIYYKEQQERITLYLKHNTEEPNTIKSVHFTSLKRGPMGDAVIEGYINENKEDDFVAYGSPEHNYQFGGDMVESERLSELLKPAHERKSPDDIKKELNKKKNH
>NZ_CP040230.1|WP_001084931.1|2510918_2512127_+|hypothetical-protein
MNSIYDKDTTYRALAKEAYHLEPDQEKIFVPYSKEKKIEFRIVAFRQNKFNGLKMAGLSPVEKGAKLNTDELYIVYAGTDPDLLADFGSDSIEDLKVGMAKFGGGLRIPPTKKERAIYGNLNKKMIDYDDGISGISQNIMTNPISQSKESYIFTGALINKQKPKHVYGAAHSLGGGLALLNGVMYNFDGVRAFSAPNTFDLLPDEVKANYRSEKYDGKFINYLHRSDIIGNSDLFAQRIGTQIYGKDVGRFSLLNPILGHGMDTFEFKGDNVRIKMDTEEMSKIASDLKASCEFVNDAIKSYQKYMDDTKAAAKRIERKYTKKIRTGNYKHIKPSDIEDYMEELSVSGKYEFYNDTAFETVMSELNRIRKNVESFADKLKHAGEKMESRDKEIGELYKIFER
>NZ_CP040230.1|WP_000505991.1|2512132_2512447_+|hypothetical-protein
MGFLDDLAESIEEQSDLSEFKQAMKSELQTKVEEAKAKIESIDEDIWDWQTTVNNKRDAIEEYCEGKTAEHAIERLMQDKQDIAGMRWTAEDAEKSCKVGSWFW
>NZ_CP040230.1|WP_001124998.1|2514323_2514743_-|DUF1433-domain-containing-protein
MPKKTIFIIIGVILCISIVTGGIYLKMKHDEKEKQKEIYYKEQQERITLYLKHNTKEPNTIKTVHFTNLKTGPMGDIEIYGYINSKKDYDFIAYNSPEENYQFTGGLTGSNEVLGKLKNAENLKSPEKIKEELNNKKDH

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Crispr_ID: NZ_CP040230_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040230_13

2532090-2532200

Orphan

Consensus_repeat	Method
GGTACTTCTGGTGTCGGTGGCGTTGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP040230_13

>merge|NZ_CP040230|13|2532090-2532200|CRISPRCasFinder
GGTACTTCTGGTGTCGGTGGCGTTGGTTCGCCTGGCTCACTCGGCACTTCTGGTGTCGGTGGTGTTGGTGTTTCCGGCTCACTCGGTACTTCTGGTGTCGGTGGTGTTGGT

>NZ_CP040230|13|13|2532090-2532200|CRISPRCasFinder
GGTACTTCTGGTGTCGGTGGCGTTGGT	TCGCCTGGCTCACTCGGCACTTCTGGTGTCGGTGGTGTTGGTGTTTCCGGCTCACTC
GGTACTTCTGGTGTCGGTGGTGTTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040230.1\|WP_000581897.1\|2520222_2520987_-\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_CP040230.1\|WP_000083859.1\|2517837_2519193_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238287
NZ_CP040230.1\|WP_000274558.1\|2538393_2539071_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP040230.1\|WP_000876647.1\|2536815_2538369_-\|gluconokinase	unknown	unknown	gnl\|CDD\|130381
NZ_CP040230.1\|WP_000217726.1\|2526853_2527162_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001825629.1\|2543970_2544174_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001117057.1\|2541079_2541496_-\|DUF2188-domain-containing-protein	unknown	unknown	gnl\|CDD\|227213
NZ_CP040230.1\|WP_014937076.1\|2519189_2519975_-\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_CP040230.1\|WP_072434834.1\|2535006_2535300_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_001825622.1\|2522114_2523044_-\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|370247
NZ_CP040230.1\|WP_000289136.1\|2540156_2540849_-\|GTP-pyrophosphokinase-family-protein	unknown	unknown	gnl\|CDD\|225232
NZ_CP040230.1\|WP_138742499.1\|2523139_2524333_+\|DNA-(cytosine-5-)-methyltransferase	unknown	unknown	gnl\|CDD\|273211
NZ_CP040230.1\|WP_031774865.1\|2521098_2521872_-\|tandem-type-lipoprotein	unknown	unknown	gnl\|CDD\|367972
NZ_CP040230.1\|WP_000678764.1\|2526443_2526710_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040230.1\|WP_000074000.1\|2539227_2539992_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
NZ_CP040230.1\|WP_000660709.1\|2544369_2545647_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_CP040230.1\|WP_000481425.1\|2535340_2536699_-\|gluconate-permease	unknown	unknown	gnl\|CDD\|129873
NZ_CP040230.1\|WP_000721337.1\|2527287_2528154_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NZ_CP040230.1\|WP_138742512.1\|2541634_2543458_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|224208
NZ_CP040230.1\|WP_014653252.1\|2524408_2526160_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092

Protein	Function_ID	Function_description	E-value
NZ_CP040230.1\|WP_000581897.1\|2520222_2520987_-\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.21828e-125
NZ_CP040230.1\|WP_000083859.1\|2517837_2519193_-\|hypothetical-protein	gnl\|CDD\|238287	cd00519, Lipase_3, Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site. .	0.00130687
NZ_CP040230.1\|WP_000274558.1\|2538393_2539071_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.62004e-44
NZ_CP040230.1\|WP_000876647.1\|2536815_2538369_-\|gluconokinase	gnl\|CDD\|130381	TIGR01314, gntK_FGGY, gluconate kinase, FGGY type. Gluconate is derived from glucose in two steps. This model describes one form of gluconate kinase, belonging to the FGGY family of carbohydrate kinases. Gluconate kinase phosphoryates gluconate for entry into the Entner-Douderoff pathway. [Energy metabolism, Sugars].	0
NZ_CP040230.1\|WP_000660709.1\|2544369_2545647_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.24287e-91
NZ_CP040230.1\|WP_001117057.1\|2541079_2541496_-\|DUF2188-domain-containing-protein	gnl\|CDD\|227213	COG4876, COG4876, Uncharacterized protein conserved in bacteria [Function unknown].	1.54722e-61
NZ_CP040230.1\|WP_014937076.1\|2519189_2519975_-\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	2.08363e-133
NZ_CP040230.1\|WP_001825622.1\|2522114_2523044_-\|restriction-endonuclease	gnl\|CDD\|370247	pfam09019, EcoRII-C, EcoRII C terminal. The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites.	1.56829e-12
NZ_CP040230.1\|WP_000289136.1\|2540156_2540849_-\|GTP-pyrophosphokinase-family-protein	gnl\|CDD\|225232	COG2357, COG2357, PpGpp synthetase catalytic domain [General function prediction only].	8.50652e-86
NZ_CP040230.1\|WP_138742499.1\|2523139_2524333_+\|DNA-(cytosine-5-)-methyltransferase	gnl\|CDD\|273211	TIGR00675, Modification_methylase, DNA-methyltransferase (dcm). All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	1.85672e-125
NZ_CP040230.1\|WP_031774865.1\|2521098_2521872_-\|tandem-type-lipoprotein	gnl\|CDD\|367972	pfam04507, DUF576, Csa1 family. This family contains several uncharacterized staphylococcal proteins. These proteins have been called conserved staphylococcal antigens (Csa).	3.80143e-129
NZ_CP040230.1\|WP_000074000.1\|2539227_2539992_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	3.96069e-33
NZ_CP040230.1\|WP_000481425.1\|2535340_2536699_-\|gluconate-permease	gnl\|CDD\|129873	TIGR00791, Gluconate_permease, gluconate transporter. This family includes known gluconate transporters of E. coli and Bacillus species as well as an idonate transporter from E. coli. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	2.53789e-168
NZ_CP040230.1\|WP_000721337.1\|2527287_2528154_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	5.5142e-177
NZ_CP040230.1\|WP_138742512.1\|2541634_2543458_-\|FUSC-family-protein	gnl\|CDD\|224208	COG1289, COG1289, Predicted membrane protein [Function unknown].	1.10855e-83
NZ_CP040230.1\|WP_014653252.1\|2524408_2526160_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0

>NZ_CP040230.1|WP_000721337.1|2527287_2528154_-|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKELGL
>NZ_CP040230.1|WP_000217726.1|2526853_2527162_+|hypothetical-protein
MTVNIVVSIVFCISMVVLSIYVAITKDFTLISYINQTTIADKHKNQIAYIFALCISLSAVFLMSAILCFEYDFIALAFLFLTIALLLIALFYVCFYKITKYP
>NZ_CP040230.1|WP_000678764.1|2526443_2526710_+|hypothetical-protein
MKGSKQILLIMGIISLIVLFIFTLFIMAQYAKHYEQKSDSSNAHTLNSSSAIIEQHTMSNLASLDLYAPVRNITSSRDIHPIYFMTKD
>NZ_CP040230.1|WP_014653252.1|2524408_2526160_+|phospho-sugar-mutase
MFFYFWGVFLYNSLHKCKGFSFHVLLSLTEILKGCLATMDKELWIERANDSLVKHFYEQQSDIEQREGFESKLTFGTAGIRGKFGLGEGRLNKFTIEKLALGLSRYLNAQTNNPTIVIHYDIRHLSTEFAQIIANVLANHQITVYLPDTYKTTPELSFAVRNLNTTAGIMITASHNPKDYNGIKVYGSDGAQLSTDASELVSRYIEDVGDPLQIDISFSKHNSSYIKPLPKSVAENYIKHIQNMIGYIPKSDLQVVFTSLHGTSVPIVPELLKSLNFNQFNLVEAQCKPDPNFSSVQSANPEDHRAFDQAVELANKSHADLLISTDPDADRLGIAERDAHGHITYFNGNQIGALLLNYRIQQTSQLRHRLMIQSIVSSELTKSLARYNNVEYKEVLTGFKFIAQEIRQLDDHQNMIFAFEESYGFLSEPFVRDKDAVQIVPLIIKYASELKLYGKTLKDELEQIYQTVGRHEDTLFSHTLEGLEGKKKIESIMTHFRSHPPQEIQGLKVKAIEDYLTSEVHQLDKDTTSQINSPKSNVIRVLFDEGFIALRPSGTEPKIKLYVSLKCPNFDDVAQKINAMIFS
>NZ_CP040230.1|WP_138742499.1|2523139_2524333_+|DNA-(cytosine-5-)-methyltransferase
MYNNIITKNESDNSIPLNYGDFIKEKRNKLNMTQKELADSIGLPKFGDRTIRRWENYETSPSYLEYKTIMNFPDTPPYLNPNIYDYKMIDLFAGIGGTRLGFQLHGNVKCVFSSEWDKFSAKTYKANFGETPKGDITQIIADEIPTHDILVAGFPCQAFSQAGLKKGFNDTRGTLFFDIARILKAKRPKCFLLENVKNLRSHDKGKTFDIIMNTLLELDYDVSSSILRARDFGCPQNRERIYIVGFDKQQIKNAENFSFPEPLPIETSLGSILESNVNDKYTISDRLWYGHQRRKREHKAKGNGFGYSIFNETSPYTNTLSARYYKDGSEILIEQNKKNPRKLTPREAARLQGFPENYIIPVSDTQAYKQFGNSVSVPVVYAIASNIFQVLQQNKNN
>NZ_CP040230.1|WP_001825622.1|2522114_2523044_-|restriction-endonuclease
MTNLNNQLKEFKNTIKVERSKLLPSPFDMVYKNFEKLGYHKQNEQFFYDNASIIIDELRNQSWIEFKKIEKEFSKKLYSHLLDQDSENYKNMTVKEGIEKFTSKHTDEIYALQLSNTQSRRSRAGKEFESIIELVLMGANIEFVTQGSIGSGVFESSELAKLVDCVVPGAAEYNLNKRNTSLISAKTSLRERWQEVGDEMSRTKAKEMYLVTLDESISEKTLKLIEKNNIIIVTTKSVIDKNYLNSSNVISFEDMLNELHIQLLQWNNYGYPATELNNKKELYQTLIEKYDGNMFVRNYYENMLSNINV
>NZ_CP040230.1|WP_031774865.1|2521098_2521872_-|tandem-type-lipoprotein
MIHSRKLRLCLYLVLLAVFIGACGMKKEESSKDKQIKENFTKTLNLYPTKNLEDFYDKEGFRDQEFEKGDKGTWIVDSEMVIELKDKKMESRSMVLYINRNTRTTKGNFIVRELWEDSKGYAQSKDTKYPVKMEHNKIIPTKPIADDKLRKEIENFKFFVQYGDFKDINDYKDGDISYNSNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLIKGDGDLKGSSIAHKNLEFTFIENKEENIYFTDSINFKPTE
>NZ_CP040230.1|WP_000581897.1|2520222_2520987_-|tandem-type-lipoprotein
MIHSKKLTLGICLVLLIILIVGYVIMTKTNGRNAQIKEAFNKTLNVYPTKNLEDFYDKEGFRDQEFDKRDKGTWIINSGMNIQLKGGALKSRAMVLYINRNTRTAKGYFLISETTEDKKGYVHNKDKKYPVKMEHNQIIPTKPIRDDKLKKEIENFKFFVQYGDFKDYKDGDISYNPNVPSYSANYQLNNDDYNVQQLRKRYDISTKRAPELKLRGSGDLKGSSVGSKELEFNFIRNKEENVYFTDSINFKPTE
>NZ_CP040230.1|WP_014937076.1|2519189_2519975_-|tandem-type-lipoprotein
MIHSKKLKLCLCLIILSVFIGGCGMKKEESSKDKQIKENFNKTLSLYPTKNLEDFYDKEGFRDEEFEKGDKGTWIIHSKMIIETNGRNMESRGMVLYINRNTRTTKGNFVIREITEDSKGYSDSKDKKYPVKMENNRIVPMKPIHDEKLRKEIEDFKFFVQYGNFKDINDYKDGDISYNPNVPSYSAKYQLSNDDYNVKQLRKRYDIPTKKAPKLLLKGDGDLKGSSVGSKNLEFTFVENKEENIYFTDSVQYTPSEDNNL
>NZ_CP040230.1|WP_000083859.1|2517837_2519193_-|hypothetical-protein
MSQTEYQIKPGNIKANSEETSTVSKISYEIENANNSGLKKGKINEQIEGLKEEGKFPKNLKYLKSYTDPNTGTTTTAFKNKDTGKVTLGMTGTNLHFEEMGNVLKHPFNHSDQDMKDMKEMLKDFGADANIGLGAVTDKDPHFKDTQDFIKDIKKEYEIDTITGHSLGGRDAIILGVSNDIKNIVVYNPAPLSITDFRIIALNNMTYSAIGDIEIKEMLKNYNGHIVRFVSDKDELDGFVSQFMYDTAGEKIVLNNGEGHDMGAFLRKYAQAKILAELRKVKGYEDANNKSFKSVKDNTKSKLGKVEELRVNWLQANGGALTSSQLKLLESVSALIIAEGLSQLVKEESNQLEKMYDNMKDKFQENWKNSQEAGNKIGTKLSHDGVLTALRNGDAYESKFETEPLTKIEQKLKELNDINSDCHNYVSKIKDSVNAIVGNDQLLASQIAGVI
>NZ_CP040230.1|WP_072434834.1|2535006_2535300_-|hypothetical-protein
MALKHVYFYVENRLKYLESERYKKYIGYFSVMKGVSRHVFVRIVQAIIMKRLVYCFKLDNDEFNFKNKYKKYKPCVTRVFDDLNTIYRYISNNKIIN
>NZ_CP040230.1|WP_000481425.1|2535340_2536699_-|gluconate-permease
MFNEIWPLISVVLGIVILLVLIIGFKLNTFISLIITSMITALMLGIPLTKIMETIEKGMGSTLGHIALIFGLGAILGKLLADGGGATRIADTLIQKFGQKHVQWAMLVAAFIVGIALFFEVGLVLLIPLVFTVAKRANVSVLKLGLPMVTALSVTHGFLPPHPGPVVIAKELKANVGDVLLYGMIIAIPVTLIAGPIFNKVAQKMIPSAYTREGDISALGAQKEFTDQEMPGFGMSLLTATLPVILMLVSTITQLVTGHDKPTNLFESIIYMIGTAGTAMLIAVLFAIVTMGLMRKRKMNHIMESVTNAIYPIGMMLLIIGGGGTFKQVLIDGGVGNTIAKMFEGTEMSPILLAWIVAAVLRIALGSATVAAISTTGIVLPLLQSSDVNVALVVLAIGAGSVILSHVNDAGFWMFKEYFGLTVKETFLTWSLLETIISVSGIIFILFISLFV
>NZ_CP040230.1|WP_000876647.1|2536815_2538369_-|gluconokinase
MKYMIGVDIGTTSTKSVLYDENGTFIMKHQIGYDLHTPNVDVSEENPDELFDAVLMTIKYIMRESKVNQDDIKFVSFSAQMHSLIAMDQQHQRLTNNITWADNRAAKYATVINEVHDGNAIYQRTGTPIHPMSPLAKIFWMKHEWQDVFQRTAKFADIKTYIFYHLFDRYIIDYSMASATGMFNLETLDWDVGALELLGISEEMLPELVPTTYVMKGMKERYATLMGLNEDTPFVIGASDGVLSNLGVNSVGKGEVAVTIGTSGAIRTVIDKPRTDYKGRIFCYVLTEDHYVIGGPVNNGGVVLRWLRDELLASEVETAKRLGVDPYDVLTQIAKRVKPGADGLIFHPYLAGERAPLWNANARGSFFGLTLSHKKEHMIRAALEGVLYNLYTVYLALIEVMNETPKMIKATGGFAKSEVWRQMMSDIFDTELVVPESYESSCLGACVLGLKAVGDIEDFSIVSSMVGATNNHTPIEENVAVYQELVSIFINLSRSLTENYEQISDFQRQHMAENKTQ
>NZ_CP040230.1|WP_000274558.1|2538393_2539071_-|GntR-family-transcriptional-regulator
MYGYPEKWLEGMTTGEGIAAELRLGIVNGHIAEGTLLTENQMAKQFNVSRSPIRDAFKLLQQNQLIQLERMGAHVLPFGEQEKKEMYDLRLMLESFAFSRVKNQERLPIVKEMKKQLEMMKVAVKFEDAESFTKHDFEFHETLIKASNHQYLNSFWSHLKPVMMALVLTSMRQRMQQNPQDFERIHHNHQVFIDAVEQYDSQILKEAFHLNFDDVGKDIEGFWLN
>NZ_CP040230.1|WP_000074000.1|2539227_2539992_-|MerR-family-transcriptional-regulator
MSNYSTGELAKLCNVTTRTIQYYDRKGILKPQGFTEGKRRVYTEQQRQTLELILLLKDLGCALSDIDMLLKGEGTLKTLNTLLTMKQQEINQQVKQQQAVLDKIKNVQYYVNEASTSPITHLKDIEHVMSKSAEMKSIRRNIWISAGIIGIIQYSSIISAILMKNKWPFLIALPFMISYGIGITIYYQRKVAYLCPNCQHIFSPSLWAVIKAKHTATTRRFECPNCHETHYCIEVPKTHMSTEQLEVPRTKNNN
>NZ_CP040230.1|WP_000289136.1|2540156_2540849_-|GTP-pyrophosphokinase-family-protein
MYVDRKPSLYLEDLRHDFKNSLSKFENGDEAFDTLLGFVELDHIYSSALKEISTKLSILDDNFNHIYKHNPIHHMERRVKEMRSLIEKLNRKGLQISAETAKEHILDIAGIRVVCNYLDDIYLIEEMLLKQEDVQLIKRKDYIQHPKENGYRSLHIVVSIPVFLAERVEVLPVEIQIRTIGMDMWASLEHKIRYKNNAETEKYRDLLKECATEITEVEDKLQQIHSEITE
>NZ_CP040230.1|WP_001117057.1|2541079_2541496_-|DUF2188-domain-containing-protein
MPFTMKGYPEKWKEFEVIKRQKAIEIANAMLKEGYLEKDVVPIAAKKAKDWYRALSKEEIKALEEENFVQFHTATMEKTEVDSEYATTDNEEHIQEQSNQDKSYFDSESIVNQSGGVRQREPLMDGPHPKVVESFKDV
>NZ_CP040230.1|WP_138742512.1|2541634_2543458_-|FUSC-family-protein
MIIPAIIGYLCGNFQFGLLVATGTLAHIYVFKGPSRSKLRTVIICNLAFAICMILGTLTATTPLVFGMTLLIVTVIPFYIFTTLKIAGPSSTFFIVTFSLPINLPIAPEEALYRGFAILVGGVLATMMVLITILLSKNKAEEQAIQNDFKLISKLLHAYNDKSAFSQVAKTAVDSFKASDKLLITSNSSSDKLSGRFQKLLLLHTSAQGIYSELLELNAKQIRPLPDELIEMMDHIITQRDDRNKNVRYWRKEVTVTEEFQNLFNHILKIDEMVHANEARIAYEAEMRKPLYSKRIYQNLTLDSIVFRNTLRYAAIMMIAIFIALMFDFEKAYWIPLSAHTVLLGTSTIHAIERGIARGLGTILGVLVLSVILLFSIPTPVAVILMGIAALFTEALVGANYTIAVVFITIQVILMNGLASQNLTINIAFPRVIDVAMGIVIAIIGLFVLGQRTASALLPYVMAEVVRKEATLFHYLFSENQYKDDVYQKNTAMNLSVKLNNMTQVYNAANGELFSDKTLIQNYYPSLFALEEISFMLNRAMANEDRLTINEQLMGEYLATFENIAKHLELNTELEIKILPDLPQYNYIQSAMMNIQHNGFRERDKNV
>NZ_CP040230.1|WP_001825629.1|2543970_2544174_-|hypothetical-protein
MKGNLEKYIRSLPLIGLIISIFLIILYFLIYRVEGNFCVIILYCLLPLFVNTSLYILYIIIFRYFKK
>NZ_CP040230.1|WP_000660709.1|2544369_2545647_-|MFS-transporter
MKEKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVKPDQPLIVSDDKAIEK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	936912-936942	0	1.0
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	1917187-1917217	0	1.0
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	2019265-2019295	0	1.0
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	916120-916150	0	1.0
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	731898-731922	0	1.0
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	2019253-2019277	0	1.0
NZ_CP040230_10	10.1\|2328084\|26\|NZ_CP040230\|CRISPRCasFinder	2328084-2328109	26	NZ_CP040230.1	1604608-1604633	0	1.0
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	242247-242277	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	242305-242335	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	242363-242393	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	866781-866811	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	1030954-1030984	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	2281868-2281898	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	335960-335990	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	606362-606392	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	731880-731910	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	1131249-1131279	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	1816450-1816480	1	0.968
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	2327972-2328002	1	0.968
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	731689-731713	1	0.96
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	1727011-1727035	1	0.96
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	866769-866793	1	0.96
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	936900-936924	1	0.96
NZ_CP040230_10	10.1\|2328084\|26\|NZ_CP040230\|CRISPRCasFinder	2328084-2328109	26	NZ_CP040230.1	866845-866870	1	0.962
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	787205-787235	2	0.935
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	1340232-1340262	2	0.935
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	1386321-1386351	2	0.935
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	2292606-2292636	2	0.935
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	2742513-2742543	2	0.935
NZ_CP040230_2	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	NZ_CP040230.1	870889-870919	2	0.935
NZ_CP040230_3	3.1\|871213\|31\|NZ_CP040230\|CRISPRCasFinder	871213-871243	31	NZ_CP040230.1	772622-772652	2	0.935
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	335978-336002	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	606380-606404	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	916138-916162	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	1131156-1131180	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	1131267-1131291	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	1816468-1816492	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	2431783-2431807	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	242235-242259	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	242293-242317	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	242351-242375	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	1030942-1030966	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	1917175-1917199	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	2281856-2281880	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	2292594-2292618	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	2292649-2292673	2	0.92
NZ_CP040230_4	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	NZ_CP040230.1	2742501-2742525	2	0.92
NZ_CP040230_10	10.1\|2328084\|26\|NZ_CP040230\|CRISPRCasFinder	2328084-2328109	26	NZ_CP040230.1	870990-871015	2	0.923
NZ_CP040230_10	10.1\|2328084\|26\|NZ_CP040230\|CRISPRCasFinder	2328084-2328109	26	NZ_CP040230.1	1335903-1335928	2	0.923
NZ_CP040230_10	10.1\|2328084\|26\|NZ_CP040230\|CRISPRCasFinder	2328084-2328109	26	NZ_CP040230.1	2105125-2105150	2	0.923
NZ_CP040230_10	10.1\|2328084\|26\|NZ_CP040230\|CRISPRCasFinder	2328084-2328109	26	NZ_CP040230.1	2459907-2459932	2	0.923

1. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 936912-936942, mismatch: 0, identity: 1.0

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
*******************************

2. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 1917187-1917217, mismatch: 0, identity: 1.0

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
*******************************

3. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 2019265-2019295, mismatch: 0, identity: 1.0

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
*******************************

4. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 916120-916150, mismatch: 0, identity: 1.0

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
*******************************

5. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 731898-731922, mismatch: 0, identity: 1.0

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaaacaa	Protospacer
*************************

6. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 2019253-2019277, mismatch: 0, identity: 1.0

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaaacaa	Protospacer
*************************

7. spacer 10.1|2328084|26|NZ_CP040230|CRISPRCasFinder matches to position: 1604608-1604633, mismatch: 0, identity: 1.0

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacatagaagctggcgg	Protospacer
**************************

8. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 242247-242277, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
******************* ***********

9. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 242305-242335, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
******************* ***********

10. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 242363-242393, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
******************* ***********

11. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 866781-866811, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctatgttggggccc	Protospacer
*******************.***********

12. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 1030954-1030984, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
******************* ***********

13. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 2281868-2281898, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
******************* ***********

14. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 335960-335990, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctatgttggggccc	Protospacer
*******************.***********

15. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 606362-606392, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttgggcccc	Protospacer
*************************** ***

16. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 731880-731910, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctttgttggggccc	Protospacer
******************* ***********

17. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 1131249-1131279, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttctattcgaaattctctgtgttggggccc	Protospacer
***** *************************

18. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 1816450-1816480, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttgtcgaaattctctgtgttggggccc	Protospacer
****** ************************

19. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 2327972-2328002, mismatch: 1, identity: 0.968

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttctttttgaaattctctgtgttggggccc	Protospacer
********.**********************

20. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 731689-731713, mismatch: 1, identity: 0.96

tttcgaaaagaaattctacaaacaa	CRISPR spacer
ttttgaaaagaaattctacaaacaa	Protospacer
***.*********************

21. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 1727011-1727035, mismatch: 1, identity: 0.96

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacagacaa	Protospacer
********************.****

22. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 866769-866793, mismatch: 1, identity: 0.96

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacagacaa	Protospacer
********************.****

23. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 936900-936924, mismatch: 1, identity: 0.96

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaagcaa	Protospacer
*********************.***

24. spacer 10.1|2328084|26|NZ_CP040230|CRISPRCasFinder matches to position: 866845-866870, mismatch: 1, identity: 0.962

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacatagaagctgacgg	Protospacer
**********************.***

25. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 787205-787235, mismatch: 2, identity: 0.935

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcatttcgaaattctctatgttggggccc	Protospacer
**** **************.***********

26. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 1340232-1340262, mismatch: 2, identity: 0.935

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcggaattctctgtgttggagccc	Protospacer
**********.***************.****

27. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 1386321-1386351, mismatch: 2, identity: 0.935

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaaatctctgtgttgaggccc	Protospacer
************* ***********.*****

28. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 2292606-2292636, mismatch: 2, identity: 0.935

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttctttttgaaattctctatgttggggccc	Protospacer
********.**********.***********

29. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 2742513-2742543, mismatch: 2, identity: 0.935

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtattgggggcc	Protospacer
*********************.****** **

30. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to position: 870889-870919, mismatch: 2, identity: 0.935

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaatcctctgtgttggggacc	Protospacer
**************.************* **

31. spacer 3.1|871213|31|NZ_CP040230|CRISPRCasFinder matches to position: 772622-772652, mismatch: 2, identity: 0.935

aagaaccaatacataataaagcataagtgat	CRISPR spacer
aagaaccaatacataataaatcattagtgat	Protospacer
******************** *** ******

32. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 335978-336002, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

33. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 606380-606404, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

34. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 916138-916162, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

35. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 1131156-1131180, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaatagaaattctacagacaa	Protospacer
******* ************.****

36. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 1131267-1131291, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaatagaaattctacaagcaa	Protospacer
******* *************.***

37. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 1816468-1816492, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgacaagaaattctacaagcaa	Protospacer
****** **************.***

38. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 2431783-2431807, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcaaaaagaaattctacagacaa	Protospacer
****.***************.****

39. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 242235-242259, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

40. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 242293-242317, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

41. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 242351-242375, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

42. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 1030942-1030966, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

43. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 1917175-1917199, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

44. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 2281856-2281880, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

45. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 2292594-2292618, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcaaaaagaaattctacagacaa	Protospacer
****.***************.****

46. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 2292649-2292673, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcaaaaagaaattctacagacaa	Protospacer
****.***************.****

47. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to position: 2742501-2742525, mismatch: 2, identity: 0.92

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaggcaa	Protospacer
********************..***

48. spacer 10.1|2328084|26|NZ_CP040230|CRISPRCasFinder matches to position: 870990-871015, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacatagtagcaggcgg	Protospacer
**************** *** *****

49. spacer 10.1|2328084|26|NZ_CP040230|CRISPRCasFinder matches to position: 1335903-1335928, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagaaactggcgg	Protospacer
*************.****.*******

50. spacer 10.1|2328084|26|NZ_CP040230|CRISPRCasFinder matches to position: 2105125-2105150, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacaaaagctggcgg	Protospacer
*************.*.**********

51. spacer 10.1|2328084|26|NZ_CP040230|CRISPRCasFinder matches to position: 2459907-2459932, mismatch: 2, identity: 0.923

cggggccccaacatagaagctggcgg	CRISPR spacer
cggggccccaacacagtagctggcgg	Protospacer
*************.** *********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP040230_6	6.1\|1816523\|26\|NZ_CP040230\|CRISPRCasFinder	1816523-1816548	26	NZ_CP053838	Aliiarcobacter faecis strain CCUG 66484 plasmid pAFAEC, complete sequence	17379-17404	4	0.846
NZ_CP040230_6	6.1\|1816523\|26\|NZ_CP040230\|CRISPRCasFinder	1816523-1816548	26	NZ_CP017210	Borreliella burgdorferi strain B331 plasmid B331_cp9, complete sequence	2023-2048	4	0.846
NZ_CP040230_6	6.1\|1816523\|26\|NZ_CP040230\|CRISPRCasFinder	1816523-1816548	26	NC_008443	Borrelia burgdorferi strain Ip21 plasmid, complete sequence	5652-5677	5	0.808
NZ_CP040230_6	6.1\|1816523\|26\|NZ_CP040230\|CRISPRCasFinder	1816523-1816548	26	NC_010631	Nostoc punctiforme PCC 73102 plasmid pNPUN01, complete sequence	3460-3485	5	0.808
NZ_CP040230_6	6.1\|1816523\|26\|NZ_CP040230\|CRISPRCasFinder	1816523-1816548	26	NC_010632	Nostoc punctiforme PCC 73102 plasmid pNPUN02, complete sequence	13739-13764	5	0.808
NZ_CP040230_6	6.1\|1816523\|26\|NZ_CP040230\|CRISPRCasFinder	1816523-1816548	26	MK448662	Streptococcus satellite phage Javan97, complete genome	6198-6223	6	0.769
NZ_CP040230_8	8.1\|2094060\|34\|NZ_CP040230\|CRISPRCasFinder	2094060-2094093	34	NC_027332	Acinetobacter phage YMC13/03/R2096, complete genome	68639-68672	11	0.676
NZ_CP040230_8	8.1\|2094060\|34\|NZ_CP040230\|CRISPRCasFinder	2094060-2094093	34	KY000079	Acinetobacter phage AM24, complete genome	74925-74958	11	0.676

1. spacer 6.1|1816523|26|NZ_CP040230|CRISPRCasFinder matches to NZ_CP053838 (Aliiarcobacter faecis strain CCUG 66484 plasmid pAFAEC, complete sequence) position: , mismatch: 4, identity: 0.846

agaatttcaaaaaagaaattctacag	CRISPR spacer
agaatttcaaaaaataaaatctattg	Protospacer
************** *** ****. *

2. spacer 6.1|1816523|26|NZ_CP040230|CRISPRCasFinder matches to NZ_CP017210 (Borreliella burgdorferi strain B331 plasmid B331_cp9, complete sequence) position: , mismatch: 4, identity: 0.846

agaatttcaaaaaagaaattctacag	CRISPR spacer
acaatttcaaaaaagaaatattacac	Protospacer
* ***************** .****

3. spacer 6.1|1816523|26|NZ_CP040230|CRISPRCasFinder matches to NC_008443 (Borrelia burgdorferi strain Ip21 plasmid, complete sequence) position: , mismatch: 5, identity: 0.808

agaatttcaaaaaagaaattctacag	CRISPR spacer
ccaatttcaaaaaagaaattttccac	Protospacer
  ******************.* **

4. spacer 6.1|1816523|26|NZ_CP040230|CRISPRCasFinder matches to NC_010631 (Nostoc punctiforme PCC 73102 plasmid pNPUN01, complete sequence) position: , mismatch: 5, identity: 0.808

agaatttcaaaaaagaaattctacag	CRISPR spacer
tgaatgtcaaaaaagaaattcttgaa	Protospacer
 **** ****************  *.

5. spacer 6.1|1816523|26|NZ_CP040230|CRISPRCasFinder matches to NC_010632 (Nostoc punctiforme PCC 73102 plasmid pNPUN02, complete sequence) position: , mismatch: 5, identity: 0.808

agaatttcaaaaaagaaattctacag	CRISPR spacer
tgaatgtcaaaaaagaaattcttgaa	Protospacer
 **** ****************  *.

6. spacer 6.1|1816523|26|NZ_CP040230|CRISPRCasFinder matches to MK448662 (Streptococcus satellite phage Javan97, complete genome) position: , mismatch: 6, identity: 0.769

agaatttcaaaaaagaaattctacag	CRISPR spacer
gctttttcaaaaaagaaattctagac	Protospacer
.   ******************* *

7. spacer 8.1|2094060|34|NZ_CP040230|CRISPRCasFinder matches to NC_027332 (Acinetobacter phage YMC13/03/R2096, complete genome) position: , mismatch: 11, identity: 0.676

tgctggtaccacgatgcgtcttgatgtagtgcta	CRISPR spacer
gatcaataccacgatgcgtcttgaagtggtagaa	Protospacer
 .....****************** **.**.  *

8. spacer 8.1|2094060|34|NZ_CP040230|CRISPRCasFinder matches to KY000079 (Acinetobacter phage AM24, complete genome) position: , mismatch: 11, identity: 0.676

tgctggtaccacgatgcgtcttgatgtagtgcta	CRISPR spacer
gatcaataccacgatgcgtcttgaagtggtagaa	Protospacer
 .....****************** **.**.  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

708996 : 717891

Hokovirus(14.29%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000244415.1\|708996_710052_-	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
WP_000149344.1\|710051_710738_-	response regulator transcription factor	NA	NA	NA	NA
WP_001037805.1\|710712_711186_-	DoxX family protein	NA	NA	NA	NA
WP_001093557.1\|711526_711967_-	DM13 domain-containing protein	NA	NA	NA	NA
WP_000637685.1\|712247_712832_-	hypothetical protein	NA	NA	NA	NA
WP_001062968.1\|712930_713644_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000941336.1\|713647_714067_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_000446724.1\|714068_714737_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000121214.1\|714924_715872_+\|transposase	IS30-like element ISSau1 family transposase	Q9MBM9	Staphylococcus_prophage	1.9e-184	99.7
WP_000604516.1\|716162_716756_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	3.1e-39	44.0
WP_001217786.1\|716739_717891_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_2

733545 : 744179

uncultured_Caudovirales_phage(62.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000193750.1\|733545_735051_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_071938133.1\|735112_735319_-	hypothetical protein	NA	NA	NA	NA
WP_000930016.1\|735390_735891_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.7e-52	66.2
WP_001068490.1\|735910_736777_-	DMT family transporter	NA	NA	NA	NA
WP_078064764.1\|737161_737311_+	ribonucleoside-diphosphate reductase	NA	NA	NA	NA
WP_000692521.1\|737578_737977_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_000855505.1\|737939_740045_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000562498.1\|740164_741136_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000876311.1\|741506_742478_+	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	7.8e-141	80.2
WP_001245567.1\|742464_743421_+	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.6e-05	57.8
WP_000616865.1\|743417_744179_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	7.2e-17	30.1

DBSCAN-SWA_3

793632 : 845852

Staphylococcus_phage(88.41%)

head,tail,terminase,holin,plate,capsid,integrase

attL 794948:794967|attR 824778:824797

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001121760.1\|793632_794937_+	phosphopyruvate hydratase	W6LP63	Streptococcus_phage	6.7e-196	80.7
794948:794967	attL	NA	NA	NA	NA
WP_000785252.1\|795275_795734_+	hypothetical protein	NA	NA	NA	NA
WP_000556760.1\|795800_796034_+	preprotein translocase subunit SecG	NA	NA	NA	NA
WP_001165970.1\|796162_796903_+	prolyl oligopeptidase family serine peptidase	NA	NA	NA	NA
WP_001050055.1\|796936_799309_+	ribonuclease R	Q0GXV6	Lactococcus_phage	8.7e-93	38.8
WP_001085185.1\|799330_799795_+	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	1.5e-81	100.0
WP_000146089.1\|800306_801356_-\|integrase	site-specific integrase	W5R968	Staphylococcus_phage	1.4e-196	99.4
WP_138742447.1\|801417_801921_-	hypothetical protein	A9CR44	Staphylococcus_phage	4.9e-46	99.4
WP_000874710.1\|801972_802611_-	LexA family transcriptional regulator	A0A0E3TAG1	Staphylococcus_phage	8.8e-117	100.0
WP_001106625.1\|802800_803055_+	helix-turn-helix transcriptional regulator	B7T095	Staphylococcus_virus	1.8e-41	100.0
WP_021285963.1\|803224_803461_-	hypothetical protein	Q4ZBN3	Staphylococcus_phage	8.7e-38	97.4
WP_001148595.1\|803525_804278_+	oxidoreductase	S4SW96	Staphylococcus_phage	7.4e-139	100.0
WP_138742448.1\|804293_804497_+	hypothetical protein	A0A0E3XBM9	Staphylococcus_phage	8.8e-31	97.0
WP_054249650.1\|804684_805398_+	antirepressor	A0A059T7N7	Staphylococcus_phage	6.1e-127	98.3
WP_000455728.1\|805410_805620_+	hypothetical protein	A0A2H4PQR1	Staphylococcus_phage	9.7e-33	100.0
WP_000048129.1\|805633_805795_+	DUF1270 family protein	A0A1P8L6G0	Staphylococcus_phage	1.9e-20	100.0
WP_113555198.1\|805888_806155_+	DUF2482 family protein	A0A1P8L6F8	Staphylococcus_phage	9.5e-33	83.0
WP_113555199.1\|806197_806458_+	DUF1108 family protein	A0EWW8	Staphylococcus_phage	1.1e-41	96.5
WP_113555200.1\|806470_807007_+	hypothetical protein	A0A0H3U480	Staphylococcus_phage	1.7e-81	89.3
WP_031783581.1\|807007_807658_+	single-stranded DNA-binding protein	A0A0F6N3I5	Staphylococcus_phage	3.3e-119	99.5
WP_113555201.1\|807654_808095_+	single-stranded DNA-binding protein	G4KNN8	Staphylococcus_phage	2.9e-58	81.0
WP_113555202.1\|808106_808802_+	hypothetical protein	A0A2I6PDA6	Staphylococcus_phage	3.9e-126	97.3
WP_138742449.1\|808773_809595_+	replication protein	A0A0H4IP66	Staphylococcus_phage	3.3e-116	99.3
WP_000443353.1\|809607_810393_+	ATP-binding protein	A0A0H4J332	Staphylococcus_phage	1.9e-145	100.0
WP_000628837.1\|810389_810548_+	hypothetical protein	A0A0H3U301	Staphylococcus_phage	3.4e-22	100.0
WP_138742450.1\|810560_810782_+	DUF3269 family protein	A7TWN4	Staphylococcus_phage	6.4e-35	98.6
WP_138742451.1\|810792_811197_+	DUF1064 domain-containing protein	A0A059T5A5	Staphylococcus_phage	2.4e-72	98.5
WP_031918004.1\|811201_811387_+	DUF3113 family protein	A0A1W6JPY2	Staphylococcus_phage	3.2e-27	98.4
WP_054249697.1\|811387_811645_+	helix-turn-helix transcriptional regulator	Q9MBR5	Staphylococcus_prophage	5.4e-41	98.8
WP_138742452.1\|811656_812016_+	hypothetical protein	Q4ZBU0	Staphylococcus_virus	1.9e-60	96.6
WP_064127572.1\|812015_812264_+	DUF3310 domain-containing protein	A0A059T7J9	Staphylococcus_phage	2.0e-40	100.0
WP_078090474.1\|812269_812518_+	hypothetical protein	A0A0K1LL46	Staphylococcus_phage	4.0e-41	97.6
WP_110166336.1\|812532_812784_+	DUF1024 family protein	A0A2H4PQK1	Staphylococcus_phage	5.4e-38	97.6
WP_000454994.1\|812947_813229_+	hypothetical protein	A0A2I6PDX3	Staphylococcus_phage	8.5e-48	100.0
WP_001061842.1\|813405_813912_+	hypothetical protein	M9NS45	Staphylococcus_phage	5.9e-92	100.0
WP_138742453.1\|813948_814194_+	hypothetical protein	Q9B0F1	Staphylococcus_virus	5.5e-27	87.7
WP_000195791.1\|814190_814397_+	DUF1381 domain-containing protein	A0A0H4IPW6	Staphylococcus_phage	4.5e-30	100.0
WP_000166075.1\|814393_814567_+	transcriptional activator RinB	A0A0H4ISR0	Staphylococcus_phage	3.7e-22	100.0
WP_000286968.1\|814567_814969_+	hypothetical protein	A0A2H4PQK5	Staphylococcus_phage	5.6e-69	100.0
WP_000594085.1\|815320_815815_+	hypothetical protein	A0A0H4J343	Staphylococcus_phage	8.4e-83	100.0
WP_001807202.1\|815807_817016_+\|terminase	PBSX family phage terminase large subunit	A0A0H4ITX6	Staphylococcus_phage	1.0e-235	100.0
WP_044119665.1\|818386_819367_+	hypothetical protein	Q4ZAW9	Staphylococcus_virus	6.6e-180	98.8
WP_138742454.1\|819464_820061_+	hypothetical protein	C7F7L8	Staphylococcus_phage	1.3e-77	99.5
WP_138742455.1\|820081_820906_+\|capsid	N4-gp56 family major capsid protein	A0A0H4J347	Staphylococcus_phage	2.8e-147	99.3
WP_000278801.1\|820922_821249_+	hypothetical protein	W5RAP1	Staphylococcus_phage	7.3e-51	100.0
WP_000338937.1\|821248_821563_+\|head,tail	phage head-tail adapter protein	W5R991	Staphylococcus_phage	8.8e-54	100.0
WP_000482986.1\|821555_821891_+\|head	phage head closure protein	A0A2H4PQL0	Staphylococcus_phage	3.0e-60	100.0
WP_001151336.1\|821877_822291_+	HK97 gp10 family phage protein	A0A0H4IPA6	Staphylococcus_phage	3.4e-77	100.0
WP_000270194.1\|822303_822741_+	DUF3168 domain-containing protein	A0A0H4J350	Staphylococcus_phage	7.9e-77	100.0
WP_000046067.1\|822727_823288_+	hypothetical protein	A0A0H4ITY2	Staphylococcus_phage	5.9e-101	100.0
WP_000141084.1\|823349_823844_+	hypothetical protein	A0A0H4IPX9	Staphylococcus_phage	2.5e-87	100.0
WP_000204079.1\|823864_824206_+	hypothetical protein	W5R8J4	Staphylococcus_phage	3.5e-56	100.0
WP_138742456.1\|824208_827178_+\|terminase	terminase	W5R9L9	Staphylococcus_phage	2.5e-262	99.7
824778:824797	attR	NA	NA	NA	NA
WP_000560199.1\|827192_828128_+\|tail	phage tail protein	A0A0H4J355	Staphylococcus_phage	4.8e-180	100.0
WP_021286119.1\|828138_830025_+	peptidase	W5RAP4	Staphylococcus_phage	0.0e+00	100.0
WP_021286118.1\|830037_831936_+	hypothetical protein	W5R996	Staphylococcus_phage	0.0e+00	100.0
WP_021286117.1\|831935_833759_+\|plate	BppU family phage baseplate upper protein	W5R8J5	Staphylococcus_phage	9.4e-297	100.0
WP_021286116.1\|833758_834136_+	DUF2977 domain-containing protein	W5R9M2	Staphylococcus_phage	5.3e-61	100.0
WP_031788726.1\|834145_834319_+	XkdX family protein	Q8LTH6	Staphylococcus_phage	9.5e-26	98.2
WP_000466769.1\|834359_834659_+	DUF2951 domain-containing protein	Q4ZBP8	Staphylococcus_phage	1.3e-46	100.0
WP_021286114.1\|834795_836670_+	CHAP domain-containing protein	W5R999	Staphylococcus_phage	0.0e+00	100.0
WP_021286113.1\|836682_837855_+\|plate	BppU family phage baseplate upper protein	W5R8J6	Staphylococcus_phage	6.4e-198	100.0
WP_021286112.1\|837860_838256_+	hypothetical protein	W5R9M8	Staphylococcus_phage	2.7e-68	100.0
WP_000351119.1\|838311_838587_+\|holin	phage holin	A0A0F6N3M0	Staphylococcus_phage	8.6e-45	100.0
WP_021286111.1\|838573_839986_+	CHAP domain-containing protein	A0A0F6N3N1	Staphylococcus_phage	5.4e-284	99.6
WP_001035620.1\|840045_840603_-	DUF4888 domain-containing protein	A0A0F6N4L1	Staphylococcus_phage	7.4e-96	100.0
WP_001788502.1\|840977_841130_+	hypothetical protein	A0A0F6N3H2	Staphylococcus_phage	3.1e-20	100.0
WP_000139423.1\|841200_841311_+	hypothetical protein	W5R8J7	Staphylococcus_phage	1.7e-12	100.0
WP_000382163.1\|841297_841498_+	hypothetical protein	W5R9N2	Staphylococcus_phage	3.7e-29	100.0
WP_000528632.1\|842133_842691_+	hypothetical protein	W5R8Q1	Staphylococcus_phage	5.7e-104	100.0
WP_017804629.1\|843190_843394_+	hypothetical protein	Q4ZBW5	Staphylococcus_virus	1.8e-15	62.7
WP_000280154.1\|844147_844693_+	hypothetical protein	NA	NA	NA	NA
WP_000757407.1\|845123_845852_-	DUF5067 domain-containing protein	H9A0X8	Staphylococcus_phage	1.3e-18	37.5

DBSCAN-SWA_4

939422 : 1000398

Planktothrix_phage(22.22%)

bacteriocin,tRNA,protease,transposase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000121214.1\|939422_940370_+\|transposase	IS30-like element ISSau1 family transposase	Q9MBM9	Staphylococcus_prophage	1.9e-184	99.7
WP_000353948.1\|940527_943137_+	ATP-dependent chaperone ClpB	A0A223W0B1	Agrobacterium_phage	5.5e-117	34.3
WP_001047061.1\|943195_944065_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_000700886.1\|944195_944711_+	YbhB/YbcL family Raf kinase inhibitor-like protein	NA	NA	NA	NA
WP_000769695.1\|945021_945456_+	MAP domain-containing protein	NA	NA	NA	NA
WP_000682089.1\|945712_945898_-	YjzD family protein	NA	NA	NA	NA
WP_001100526.1\|946192_947134_+	ketoacyl-ACP synthase III	NA	NA	NA	NA
WP_000081234.1\|947145_948390_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_000915159.1\|948444_948816_-	DUF3899 domain-containing protein	NA	NA	NA	NA
WP_000521531.1\|949058_949985_+	ABC transporter permease	NA	NA	NA	NA
WP_000829637.1\|949984_951055_+	ABC transporter permease	NA	NA	NA	NA
WP_000140050.1\|951070_952153_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.4e-19	28.8
WP_000786744.1\|952142_953084_+	ABC transporter ATP-binding protein	F2Y1V6	Organic_Lake_phycodnavirus	9.3e-06	26.9
WP_000197091.1\|953102_954758_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001807927.1\|954927_955863_+	ABC transporter permease	NA	NA	NA	NA
WP_000234061.1\|955852_956872_+	ABC transporter permease	NA	NA	NA	NA
WP_000976731.1\|956884_957967_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.4e-18	30.4
WP_000406183.1\|958910_960533_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000448934.1\|960652_961642_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
WP_000258003.1\|961937_962333_+	transcriptional regulator Spx	NA	NA	NA	NA
WP_001217731.1\|962703_963423_+	adaptor protein MecA	NA	NA	NA	NA
WP_000959279.1\|963543_964530_+	competence protein CoiA	NA	NA	NA	NA
WP_000082727.1\|964577_966386_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	1.2e-46	24.4
WP_117223958.1\|966845_967652_-	DsbA family protein	NA	NA	NA	NA
WP_031886501.1\|967674_968040_-	globin	NA	NA	NA	NA
WP_000224612.1\|968143_968737_-	CYTH domain-containing protein	NA	NA	NA	NA
WP_001242104.1\|968922_969270_+	hypothetical protein	NA	NA	NA	NA
WP_001077683.1\|969286_969922_+	GTP pyrophosphokinase family protein	NA	NA	NA	NA
WP_001270834.1\|969938_970748_+	NAD kinase	NA	NA	NA	NA
WP_000669942.1\|970744_971599_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_000062407.1\|971619_973005_+	magnesium transporter	NA	NA	NA	NA
WP_000395153.1\|973014_974859_+	sodium:proton antiporter	NA	NA	NA	NA
WP_000933200.1\|975136_975907_+	enoyl-ACP reductase FabI	NA	NA	NA	NA
WP_000933105.1\|976103_977189_-	AI-2E family transporter	NA	NA	NA	NA
WP_000570705.1\|977530_979099_+	alanine:cation symporter family protein	NA	NA	NA	NA
WP_000889181.1\|979240_979999_+	esterase family protein	NA	NA	NA	NA
WP_000600387.1\|980192_980702_+	hypothetical protein	NA	NA	NA	NA
WP_001794241.1\|980814_982023_-	MFS transporter	NA	NA	NA	NA
WP_000258650.1\|981982_983158_-	diglucosyl diacylglycerol synthase	NA	NA	NA	NA
WP_000340124.1\|983588_985073_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_072434963.1\|985053_985314_+	hypothetical protein	NA	NA	NA	NA
WP_001049947.1\|985313_986876_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	3.8e-36	28.0
WP_138742510.1\|987177_987981_+	TerC family protein	S5MAL1	Bacillus_phage	1.7e-29	40.0
WP_138742461.1\|988199_990524_+\|protease	trypsin-like serine protease	W5SAB9	Pithovirus	2.1e-11	27.4
WP_000021872.1\|990540_991899_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000414168.1\|992037_993549_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
WP_000287265.1\|994037_994607_-	competence protein ComK	NA	NA	NA	NA
WP_000876826.1\|994816_995035_+	IDEAL domain-containing protein	NA	NA	NA	NA
WP_000668814.1\|995115_996102_-	lipoate--protein ligase	NA	NA	NA	NA
WP_000214898.1\|996300_996477_+	YkvS family protein	NA	NA	NA	NA
WP_001033867.1\|996491_997094_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_099119695.1\|997393_997471_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_000790905.1\|998105_998390_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
WP_000870811.1\|998433_1000398_+\|bacteriocin	bacteriocin-associated integral membrane family protein	NA	NA	NA	NA

DBSCAN-SWA_5

1032449 : 1040922

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001807816.1\|1032449_1032932_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
WP_001010409.1\|1032918_1034043_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000174055.1\|1034046_1034751_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	2.1e-47	42.1
WP_000848351.1\|1034750_1035014_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666799.1\|1035015_1035687_+	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000032750.1\|1035679_1037869_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.3e-140	39.4
WP_000483707.1\|1037847_1039332_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	8.5e-46	31.7
WP_000030815.1\|1039324_1040353_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.9e-61	41.1
WP_000238668.1\|1040355_1040922_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.7e-29	40.1

DBSCAN-SWA_6

1297273 : 1304033

Staphylococcus_phage(83.33%)

head

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001807853.1\|1297273_1297471_+	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	9.9e-11	50.0
WP_074347689.1\|1298157_1298385_+	hypothetical protein	A0A1W6JNK0	Staphylococcus_phage	1.9e-18	72.1
WP_001002341.1\|1298685_1298892_+	hypothetical protein	A0A2H4PQT0	Staphylococcus_phage	5.5e-12	55.2
WP_001788716.1\|1299592_1299703_+	hypothetical protein	NA	NA	NA	NA
WP_000006110.1\|1300095_1300281_+	hypothetical protein	A0A0F6N3H3	Staphylococcus_phage	2.4e-19	78.7
WP_000477489.1\|1300791_1301208_+	hypothetical protein	NA	NA	NA	NA
WP_000974166.1\|1301639_1302224_-	ATP-binding protein	A0A059NT77	Lactococcus_phage	4.4e-30	42.6
WP_000585092.1\|1302872_1303124_+	hypothetical protein	NA	NA	NA	NA
WP_074347678.1\|1303193_1304033_+\|head	head morphogenesis protein	A0A1J0MFV1	Staphylococcus_phage	1.1e-29	50.7

DBSCAN-SWA_7

1576206 : 1584518

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001213908.1\|1576206_1576992_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
WP_000924214.1\|1577117_1578008_-	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_138742469.1\|1578017_1579364_-	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
WP_000683941.1\|1579477_1580578_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	1.0e-08	30.6
WP_000624563.1\|1580580_1581258_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_001283055.1\|1581388_1582495_-	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_001217255.1\|1582718_1584518_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.5e-54	36.0

DBSCAN-SWA_8

1653942 : 1662984

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000364542.1\|1653942_1654461_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
WP_000595008.1\|1654482_1656756_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.1e-64	29.3
WP_000749801.1\|1656958_1659238_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_001160682.1\|1659511_1659772_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_001112045.1\|1659790_1660930_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001019177.1\|1660952_1661978_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001005766.1\|1661979_1662984_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_9

1785085 : 1848758

Staphylococcus_phage(84.44%)

protease,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000121214.1\|1785085_1786033_+\|transposase	IS30-like element ISSau1 family transposase	Q9MBM9	Staphylococcus_prophage	1.9e-184	99.7
WP_000285001.1\|1786408_1787677_+	NAD(P)/FAD-dependent oxidoreductase	A0A2H4PQX1	Staphylococcus_phage	4.1e-57	100.0
WP_001050516.1\|1787793_1794342_-	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	1.8e-294	94.9
WP_000836471.1\|1794665_1794977_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.3e-49	95.1
WP_001807819.1\|1794998_1797416_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.1
WP_001025063.1\|1797711_1798884_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.2e-216	99.7
WP_000526541.1\|1798993_1799947_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	6.4e-79	99.3
WP_000764426.1\|1799943_1800507_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	7.3e-99	95.7
WP_000757543.1\|1800625_1801027_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000266096.1\|1801598_1802426_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_014937042.1\|1802428_1802548_-	hypothetical protein	NA	NA	NA	NA
WP_001834472.1\|1802559_1802751_-	hypothetical protein	NA	NA	NA	NA
WP_001196354.1\|1802659_1803661_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
WP_001008555.1\|1803788_1804247_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.1e-68	97.4
WP_001159034.1\|1804259_1805441_-	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.9e-226	99.7
WP_000493892.1\|1805451_1806084_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
WP_000384182.1\|1806090_1807122_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	3.1e-196	99.1
WP_001261673.1\|1807614_1809117_-	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	5.0e-30	98.6
WP_000221190.1\|1809759_1810074_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	1.3e-52	98.1
WP_000989103.1\|1810073_1811366_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	7.5e-216	94.7
WP_001032832.1\|1811452_1812307_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000384171.1\|1812582_1812807_-	hypothetical protein	NA	NA	NA	NA
WP_000671058.1\|1813005_1813476_+	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	5.0e-69	84.6
WP_001153741.1\|1813588_1814032_+	competence protein ComK	NA	NA	NA	NA
WP_001030475.1\|1814018_1814462_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	6.4e-50	78.6
WP_001168915.1\|1814759_1815395_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000492903.1\|1815561_1816182_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_001096494.1\|1816744_1817458_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_000091443.1\|1817716_1818019_+	hypothetical protein	NA	NA	NA	NA
WP_001200546.1\|1818273_1818639_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.9e-58	98.3
WP_000623484.1\|1818635_1818989_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	2.3e-18	82.1
WP_000453302.1\|1819238_1820072_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.7e-157	98.9
WP_000366160.1\|1820283_1821192_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	1.3e-137	99.3
WP_000933822.1\|1821316_1822510_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000109913.1\|1822881_1824474_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.6
WP_016187361.1\|1824770_1825517_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.8e-141	98.0
WP_000672013.1\|1825521_1825995_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	7.2e-84	98.7
WP_000718107.1\|1826060_1826318_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000778553.1\|1826314_1827316_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	3.3e-163	86.5
WP_000348381.1\|1827320_1828799_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.7e-277	95.5
WP_016187363.1\|1828957_1829413_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	8.3e-77	96.6
WP_001825423.1\|1829715_1830378_+	excalibur calcium-binding domain-containing protein	A0A2H4PQM8	Staphylococcus_phage	2.8e-49	87.7
WP_000070644.1\|1830458_1831454_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	1.3e-69	94.8
WP_000669036.1\|1831529_1832156_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	9.9e-81	84.1
WP_000627549.1\|1832196_1832541_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	5.1e-55	96.5
WP_000414230.1\|1832638_1833211_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	3.5e-24	93.1
WP_000864133.1\|1833408_1833966_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	1.1e-78	98.1
WP_000375476.1\|1834336_1834513_-	hypothetical protein	NA	NA	NA	NA
WP_000070813.1\|1834523_1834907_-	hypothetical protein	NA	NA	NA	NA
WP_000196442.1\|1835355_1835637_-\|transposase	IS3 family transposase	A0A0C5AJ30	Paenibacillus_phage	3.2e-23	63.4
WP_000731425.1\|1835879_1836323_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000747800.1\|1836322_1836766_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000221417.1\|1837300_1839724_+	polysaccharide lyase 8 family protein	NA	NA	NA	NA
WP_031901455.1\|1839849_1840209_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000439997.1\|1840435_1840879_-	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_000877848.1\|1840921_1841227_+	hypothetical protein	NA	NA	NA	NA
WP_014532497.1\|1841296_1841686_+	hypothetical protein	NA	NA	NA	NA
WP_001095317.1\|1841665_1842433_-	ATP-binding protein	A0A059NT77	Lactococcus_phage	6.3e-53	44.6
WP_050973948.1\|1842444_1843461_-\|transposase	IS21 family transposase	A0A059NT83	Lactococcus_phage	1.6e-80	50.5
WP_001105987.1\|1843476_1844151_+\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	6.8e-128	99.6
WP_002503927.1\|1844623_1844683_+	23S rRNA methylase leader peptide ErmCL	NA	NA	NA	NA
WP_001035822.1\|1844742_1845477_+	23S ribosomal RNA methyltransferase Erm	E4ZFQ0	Streptococcus_phage	3.8e-63	52.7
WP_086011952.1\|1845517_1845682_-	replication domain protein	NA	NA	NA	NA
WP_001105987.1\|1845713_1846388_+\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	6.8e-128	99.6
WP_000825946.1\|1848293_1848758_+	hypothetical protein	A0EWV3	Staphylococcus_phage	4.0e-26	92.2

DBSCAN-SWA_10

1928279 : 2025480

116

Staphylococcus_phage(87.18%)

head,tRNA,protease,tail,transposase,holin,terminase,capsid,integrase,portal

attL 1989541:1989558|attR 2015343:2015360

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000545370.1\|1928279_1929707_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_138742483.1\|1929719_1931177_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_000170162.1\|1931178_1931481_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_000957030.1\|1931847_1933386_+	sodium/proline symporter PutP	NA	NA	NA	NA
WP_000831695.1\|1933474_1934674_-	CamS family sex pheromone protein	NA	NA	NA	NA
WP_000774571.1\|1934686_1936690_-	NAD-dependent DNA ligase LigA	A0A0K2QQN8	Ralstonia_phage	4.4e-114	36.1
WP_138742484.1\|1936693_1938886_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.7e-135	42.2
WP_000272065.1\|1938882_1939575_-	heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
WP_001165363.1\|1939746_1940049_-	hypothetical protein	NA	NA	NA	NA
WP_000572878.1\|1940157_1941453_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
WP_000827738.1\|1942301_1943468_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434536.1\|1943498_1943822_+	staphostatin A	NA	NA	NA	NA
WP_000669861.1\|1944114_1944288_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011542.1\|1944268_1944871_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040870.1\|1945144_1945966_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	6.1e-70	53.1
WP_138742485.1\|1945958_1947428_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	5.9e-108	45.1
WP_000897642.1\|1947611_1948688_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177819.1\|1948707_1949502_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|1949573_1949681_+	hypothetical protein	NA	NA	NA	NA
WP_000323172.1\|1949691_1951254_-	SLC13 family permease	NA	NA	NA	NA
WP_000275718.1\|1951458_1952556_-	pectate lyase	U5PWM6	Bacillus_phage	3.3e-47	34.6
WP_000149686.1\|1952927_1953488_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|1953540_1954470_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001826057.1\|1954662_1954836_-	hypothetical protein	NA	NA	NA	NA
WP_001021224.1\|1954887_1956267_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181321.1\|1956386_1957415_-	lactonase family protein	NA	NA	NA	NA
WP_000205106.1\|1957685_1958087_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
WP_000267034.1\|1958143_1958317_-	hypothetical protein	NA	NA	NA	NA
WP_001188070.1\|1958767_1959808_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713062.1\|1959864_1960707_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033968.1\|1960703_1961261_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966291.1\|1961320_1961845_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|1961965_1962529_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221650.1\|1962592_1963333_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000763048.1\|1963332_1964205_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645735.1\|1964201_1964882_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991294.1\|1964882_1965779_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	6.5e-17	30.7
WP_000691584.1\|1965775_1966156_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681966.1\|1966413_1966590_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|1966831_1966930_-	hypothetical protein	NA	NA	NA	NA
WP_001068535.1\|1967129_1968416_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_000669725.1\|1968686_1970756_-	MAP domain-containing protein	NA	NA	NA	NA
WP_000669789.1\|1971713_1971893_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001789576.1\|1971916_1972225_+	hypothetical protein	M9NTD8	Staphylococcus_phage	3.2e-40	100.0
WP_001791826.1\|1972203_1972464_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702263.1\|1972516_1972867_-	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_000727649.1\|1973551_1974001_+	chemotaxis-inhibiting protein CHIPS	A0A1P8L6A8	Staphylococcus_phage	1.1e-78	100.0
WP_000930259.1\|1974095_1975550_-	CHAP domain-containing protein	W5RAM3	Staphylococcus_phage	2.0e-289	100.0
WP_000387656.1\|1975561_1975864_-\|holin	phage holin	A0A2K9VBR4	Staphylococcus_phage	9.1e-48	100.0
WP_100198845.1\|1976062_1976140_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_000539688.1\|1976401_1976698_-	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
WP_001040257.1\|1976755_1977043_-	hypothetical protein	W5R962	Staphylococcus_phage	4.9e-43	100.0
WP_001181555.1\|1977089_1977242_-	hypothetical protein	W5RAM1	Staphylococcus_phage	2.0e-19	100.0
WP_000582140.1\|1977228_1980909_-	hypothetical protein	W5R8M1	Staphylococcus_phage	0.0e+00	100.0
WP_000567415.1\|1980924_1982409_-\|tail	phage tail protein	A0A1W6JPN0	Staphylococcus_phage	1.3e-296	99.8
WP_001807909.1\|1982405_1986935_-\|tail	phage tail tape measure protein	W5R8I2	Staphylococcus_phage	0.0e+00	100.0
WP_001096355.1\|1987179_1987530_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
WP_072050172.1\|1987579_1987804_-	hypothetical protein	A0A075LYE8	Staphylococcus_phage	8.8e-32	98.6
WP_000268741.1\|1987845_1988490_-\|tail	phage tail protein	W5R9H4	Staphylococcus_phage	6.5e-120	100.0
WP_000565496.1\|1988490_1988898_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	2.7e-71	99.3
WP_000114226.1\|1988894_1989299_-	hypothetical protein	G4KNQ5	Staphylococcus_phage	4.3e-69	100.0
WP_000755150.1\|1989295_1989658_-\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
1989541:1989558	attL	NA	NA	NA	NA
WP_000150936.1\|1989641_1989926_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000238236.1\|1989915_1990200_-	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
WP_000154559.1\|1990219_1991365_-\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
WP_000121214.1\|1991400_1992348_-\|transposase	IS30-like element ISSau1 family transposase	Q9MBM9	Staphylococcus_prophage	1.9e-184	99.7
WP_000642728.1\|1992463_1993201_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
WP_000025274.1\|1993184_1994372_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
WP_000625088.1\|1994387_1996049_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
WP_000402904.1\|1996045_1996390_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000988336.1\|1996519_1996819_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
WP_000590122.1\|1997050_1997467_-	hypothetical protein	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
WP_000265043.1\|1997494_1997695_-	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	1.4e-28	100.0
WP_000595265.1\|1997694_1997844_-	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_000592207.1\|1997840_1998227_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000195803.1\|1998223_1998430_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_000185660.1\|1998466_1999009_-	dUTP pyrophosphatase	A0A068A209	Staphylococcus_phage	1.1e-96	100.0
WP_000028422.1\|1999001_1999184_-	hypothetical protein	A0EWY1	Staphylococcus_phage	2.6e-26	100.0
WP_001065091.1\|1999173_1999425_-	DUF1024 family protein	A0EWY0	Staphylococcus_phage	1.9e-38	100.0
WP_000131366.1\|1999596_1999839_-	hypothetical protein	A0EWX8	Staphylococcus_phage	3.9e-41	100.0
WP_000101274.1\|1999842_2000211_-	hypothetical protein	W5RAK8	Staphylococcus_phage	8.2e-51	100.0
WP_000401960.1\|2000223_2000628_-	RusA family crossover junction endodeoxyribonuclease	A0EWX6	Staphylococcus_phage	1.9e-72	100.0
WP_000338530.1\|2000636_2000855_-	hypothetical protein	A0A2I6PDG4	Staphylococcus_phage	1.0e-37	100.0
WP_000148316.1\|2000861_2001746_-	DnaD domain protein	A0EWX4	Staphylococcus_phage	5.4e-141	100.0
WP_000934764.1\|2001775_2002246_-	single-stranded DNA-binding protein	A0EWX3	Staphylococcus_phage	7.4e-81	100.0
WP_071621397.1\|2002246_2002864_-	MBL fold metallo-hydrolase	S4SWA4	Staphylococcus_phage	9.1e-87	100.0
WP_138742486.1\|2002944_2003865_-	recombinase	S4SUN6	Staphylococcus_phage	1.9e-165	99.7
WP_000700577.1\|2003866_2005810_-	AAA family ATPase	A0EWX0	Staphylococcus_phage	0.0e+00	100.0
WP_001205732.1\|2005818_2006082_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_000291503.1\|2006090_2006351_-	DUF1108 family protein	A0EWW8	Staphylococcus_phage	8.9e-44	100.0
WP_000165375.1\|2006331_2006658_-	DUF2482 family protein	W5RAK4	Staphylococcus_phage	1.2e-53	100.0
WP_000066017.1\|2006752_2006914_-	DUF1270 domain-containing protein	D2JGJ6	Staphylococcus_phage	4.3e-20	100.0
WP_001120197.1\|2006910_2007231_-	DUF771 domain-containing protein	A0A2I6PDH6	Staphylococcus_phage	1.5e-56	100.0
WP_000275058.1\|2007289_2007922_+	hypothetical protein	A7TW95	Staphylococcus_phage	1.5e-113	100.0
WP_000939496.1\|2007936_2008077_-	hypothetical protein	A0A2I6PDG0	Staphylococcus_phage	1.9e-16	100.0
WP_001148855.1\|2008107_2008305_-	hypothetical protein	Q8SDM8	Staphylococcus_phage	7.0e-33	100.0
WP_001148605.1\|2008320_2009073_-	oxidoreductase	M9NTH5	Staphylococcus_phage	1.1e-139	100.0
WP_000128907.1\|2009123_2009453_+	hypothetical protein	M9NS98	Staphylococcus_phage	2.7e-53	100.0
WP_001025874.1\|2009441_2009657_-	DUF2829 domain-containing protein	A0EWV9	Staphylococcus_phage	6.3e-35	100.0
WP_000854072.1\|2009672_2009936_-	helix-turn-helix transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	7.2e-41	100.0
WP_001801500.1\|2009932_2010106_-	hypothetical protein	NA	NA	NA	NA
WP_001031454.1\|2010068_2010782_+	helix-turn-helix transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
WP_000759682.1\|2010797_2011730_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
WP_000591749.1\|2011735_2012077_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
WP_000705248.1\|2012280_2012463_+	hypothetical protein	M9NSW6	Staphylococcus_phage	4.1e-27	100.0
WP_000825947.1\|2012562_2013027_+	hypothetical protein	A0EWV3	Staphylococcus_phage	1.1e-28	100.0
WP_000857185.1\|2013085_2014123_+\|integrase	site-specific integrase	Q38086	Staphylococcus_phage	4.5e-179	100.0
WP_000595612.1\|2015265_2016282_-	beta-channel forming cytolysin	A0A2I6PER8	Staphylococcus_phage	1.1e-25	29.3
2015343:2015360	attR	NA	NA	NA	NA
WP_000791397.1\|2016303_2017359_-	succinyl-diaminopimelate desuccinylase	A0A2I6PER8	Staphylococcus_phage	8.7e-37	35.4
WP_000206618.1\|2017790_2019014_+	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_001045074.1\|2019396_2020704_+	potassium transporter KtrB	NA	NA	NA	NA
WP_025174349.1\|2021242_2021584_-	hypothetical protein	C8CH40	Staphylococcus_phage	3.3e-22	47.8
WP_000201398.1\|2021865_2022045_-	hypothetical protein	NA	NA	NA	NA
WP_000240642.1\|2022585_2024202_-	chaperonin GroEL	A0A240F779	uncultured_virus	3.4e-157	54.7
WP_000917289.1\|2024277_2024562_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2
WP_000197638.1\|2024736_2025480_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CP040230.1|WP_000384171.1|1812582_1812807_-|hypothetical-protein

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Acr_ID: NZ_CP040230.1|WP_000681966.1|1966413_1966590_-|hypothetical-protein

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Acr_ID: NZ_CP040230.1|WP_000990056.1|1966831_1966930_-|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP040230.1|WP_000384171.1|1812582_1812807_-|hypothetical-protein

1812582_1812807_-

74 aa aa

LuxR_C_like

Identity	Hit_domain_coverage
0.42857142857142855	0.7368421052631579

1785085-1848758

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP040230_2	Orphan	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	1816480-1816450	1
NZ_CP040230_4	Orphan	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	1816468-1816492	2

1. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to NZ_CP040230 position: 1816480-1816450, mismatch: 1

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttgtcgaaattctctgtgttggggccc	Protospacer
****** ************************

2. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to NZ_CP040230 position: 1816468-1816492, mismatch: 2

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgacaagaaattctacaagcaa	Protospacer
****** **************.***

NZ_CP040230.1|WP_000681966.1|1966413_1966590_-|hypothetical-protein

1966413_1966590_-

58 aa aa

WHTH_GntR

Identity	Hit_domain_coverage
0.48484848484848486	1.0

1928279-2025480

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP040230_2	Orphan	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	2019265-2019295	0
NZ_CP040230_4	Orphan	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	2019277-2019253	0

1. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to NZ_CP040230 position: 2019265-2019295, mismatch: 0

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
*******************************

2. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to NZ_CP040230 position: 2019277-2019253, mismatch: 0

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaaacaa	Protospacer
*************************

NZ_CP040230.1|WP_000990056.1|1966831_1966930_-|hypothetical-protein

1966831_1966930_-

32 aa aa

WHTH_GntR

Identity	Hit_domain_coverage
0.48484848484848486	1.0

1928279-2025480

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP040230_2	Orphan	2.1\|778225\|31\|NZ_CP040230\|CRISPRCasFinder	778225-778255	31	2019265-2019295	0
NZ_CP040230_4	Orphan	4.1\|1724631\|25\|NZ_CP040230\|PILER-CR	1724631-1724655	25	2019277-2019253	0

1. spacer 2.1|778225|31|NZ_CP040230|CRISPRCasFinder matches to NZ_CP040230 position: 2019265-2019295, mismatch: 0

tttcttttcgaaattctctgtgttggggccc	CRISPR spacer
tttcttttcgaaattctctgtgttggggccc	Protospacer
*******************************

2. spacer 4.1|1724631|25|NZ_CP040230|PILER-CR matches to NZ_CP040230 position: 2019277-2019253, mismatch: 0

tttcgaaaagaaattctacaaacaa	CRISPR spacer
tttcgaaaagaaattctacaaacaa	Protospacer
*************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP040230

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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