CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP035295	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed1, complete sequence	0 crisprs	csa3,WYL	0	0	0	0
NZ_CP035297	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed3, complete sequence	0 crisprs	csa3	0	0	2	0
NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1 crisprs	csa3,Cas14u_CAS-V	1	1	6	1
NZ_CP035294	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 chromosome, complete genome	1 crisprs	csa3,DEDDh,cas3,DinG	0	0	7	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 4135

Bacillus_phage(100.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011304071.1\|417_1008_-	glutamine amidotransferase	NA	NA	NA	NA
WP_011304070.1\|1183_1972_-	HAD family phosphatase	NA	NA	NA	NA
WP_103314598.1\|2850_3183_-	protein rep	NA	NA	NA	NA
WP_002440813.1\|3163_4135_-	replication initiator protein A	A0A0S2MVK1	Bacillus_phage	2.5e-06	34.7

DBSCAN-SWA_2

12902 : 22635

Staphylococcus_phage(60.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011304078.1\|12902_13271_+	Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	4.5e-57	87.7
WP_041785032.1\|13263_15681_+	cadmium-translocating P-type ATPase CadA	E4ZFI9	Streptococcus_phage	1.3e-248	63.0
WP_011304076.1\|15785_16400_+	CadD family cadmium resistance transporter	NA	NA	NA	NA
WP_011304059.1\|17166_17841_-\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.7e-126	98.7
WP_041785029.1\|17856_18342_+	hypothetical protein	NA	NA	NA	NA
WP_002324169.1\|18526_18670_+	hypothetical protein	NA	NA	NA	NA
WP_138936977.1\|20004_20679_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	2.6e-127	99.1
WP_011304072.1\|21960_22635_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	3.2e-125	97.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP035296

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP035296_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP035296_1

1743-1891

Orphan

Consensus_repeat	Method
GAGATTATGTATAAGTTGAAAGAAACAAAGTTTTGCAGTAACATGTTACATGT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP035296_1

>merge|NZ_CP035296|1|1743-1891|CRISPRCasFinder
GAGATTATGTATAAGTTGAAAGAAACAAAGTTTTGCAGTAACATGTTACATGTAACAAACAACACAAAGAATATATAAGAATGAATTAAGAACAACGAGATTATGTATAAGTTGAAAGAAACAAAGTTTTGCAGTAACATGTTACATGT

>NZ_CP035296|1|1|1743-1891|CRISPRCasFinder
GAGATTATGTATAAGTTGAAAGAAACAAAGTTTTGCAGTAACATGTTACATGT	AACAAACAACACAAAGAATATATAAGAATGAATTAAGAACAAC
GAGATTATGTATAAGTTGAAAGAAACAAAGTTTTGCAGTAACATGTTACATGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP035296.1\|WP_011304046.1\|3240_4125_-\|permease	unknown	unknown	gnl\|CDD\|223773
NZ_CP035296.1\|WP_011304044.1\|5064_5412_+\|arsenite-efflux-transporter-metallochaperone-ArsD	unknown	unknown	gnl\|CDD\|377741
NZ_CP035296.1\|WP_002448023.1\|1956_2751_+\|ParA-family-protein	unknown	unknown	gnl\|CDD\|224113
NZ_CP035296.1\|WP_002509693.1\|8780_9095_+\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP035296.1\|WP_011304045.1\|4215_4536_-\|winged-helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP035296.1\|WP_002448025.1\|2756_2957_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226420
NZ_CP035296.1\|WP_002509686.1\|3092_3227_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP035296.1\|WP_011304042.1\|7119_8784_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|163244
NZ_CP035296.1\|WP_041785003.1\|5392_7123_+\|arsenical-pump-driving-ATPase	unknown	unknown	gnl\|CDD\|275109
NZ_CP035296.1\|WP_002509689.1\|4585_4780_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234874

Protein	Function_ID	Function_description	E-value
NZ_CP035296.1\|WP_011304046.1\|3240_4125_-\|permease	gnl\|CDD\|223773	COG0701, COG0701, Predicted permeases [General function prediction only].	1.79317e-51
NZ_CP035296.1\|WP_011304044.1\|5064_5412_+\|arsenite-efflux-transporter-metallochaperone-ArsD	gnl\|CDD\|377741	pfam06953, ArsD, Arsenical resistance operon trans-acting repressor ArsD. This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)-Cys(113), that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs.	7.51693e-48
NZ_CP035296.1\|WP_002448023.1\|1956_2751_+\|ParA-family-protein	gnl\|CDD\|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	5.07985e-44
NZ_CP035296.1\|WP_002509693.1\|8780_9095_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8932e-20
NZ_CP035296.1\|WP_011304045.1\|4215_4536_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.52437e-18
NZ_CP035296.1\|WP_002448025.1\|2756_2957_+\|hypothetical-protein	gnl\|CDD\|226420	COG3905, COG3905, Predicted transcriptional regulator [Transcription].	0.00513297
NZ_CP035296.1\|WP_011304042.1\|7119_8784_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|163244	TIGR03385, Coenzyme_A_disulfide_reductase, CoA-disulfide reductase. Members of this protein family are CoA-disulfide reductase (EC 1.8.1.14), as characterized in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi, and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. [Cellular processes, Detoxification].	1.84666e-124
NZ_CP035296.1\|WP_041785003.1\|5392_7123_+\|arsenical-pump-driving-ATPase	gnl\|CDD\|275109	TIGR04291, Arsenical_pump-driving_ATPase, arsenical pump-driving ATPase. The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).	0
NZ_CP035296.1\|WP_002509689.1\|4585_4780_-\|hypothetical-protein	gnl\|CDD\|234874	PRK00955, PRK00955, YgiQ family radical SAM protein.	0.00955629

>NZ_CP035296.1|WP_002448023.1|1956_2751_+|ParA-family-protein
MNIITVGNFKGGVGKTTVSTLLSYIASENYNKKVLLIDFDPQGNATQIMKRTYPEFKEESLSFINMLKSGNIDESIIRLTSNLSLLPADSSLANLSDIISKTDILKKRYILKNVVEKIEKIYDFDYVFIDVPPTINSDFTNNAVYASNYILMVFQTQQSAYESSLSFVNFLRDRKKESDLPFELVGAVPVLIKKNGRVDKQILEMSKSAFSEALFEHQIYQRERIKKFAADGIKDKDMHDKKVIHMFNKVYEELVSRIKLIEEE
>NZ_CP035296.1|WP_002448025.1|2756_2957_+|hypothetical-protein
MAGFLDNIDTSEVKYTENYRPISKSTTMRVDTDIKKRLNQMALDKDTSIKSIIDKVLEEFLENNKY
>NZ_CP035296.1|WP_002509686.1|3092_3227_-|hypothetical-protein
MGIKDALKKLKPQEQSCCSVEIEEKTDKKDENNEKKENGNKNCC
>NZ_CP035296.1|WP_011304046.1|3240_4125_-|permease
MLDSSIEFIKTFLMLFFELLVLFIVVSFIVSIIQQIVSEEKIKHFLSKPNQVINYILGMIFGAITPFCSCSTIPILAGLLNSKVPFGPAMSFLIASPLMNPLMIFMLWILLGWKVAVVYFVVLAIFSILTGLVFSKVNLAKSYKGVNVKGDGFFTNKSGSRVKQALNDAWAFLYPMLPYLIIGVFIGAFIYGFIPESFITQYASGDSIISVIIASVIGIPMYIRPETMLPIAEALVSKGMSLGTVVALIIGGAGASIPEVVLLSKLFKKKFVISFVIAILVVAIATGLIVNLII
>NZ_CP035296.1|WP_011304045.1|4215_4536_-|winged-helix-turn-helix-transcriptional-regulator
MEVIKAKTDMNEDQQLDFYENMFNALADKNRLKILNQISQSPNKSLCVCDLEELLDLKQSKISYHLKKLVSAQILIPEKYGTWNYYKINEAQIQVVLTEDTCCKIL
>NZ_CP035296.1|WP_002509689.1|4585_4780_-|hypothetical-protein
MRVNHASTLSVGYFVSYLNLVMVSREVTLKEATIYMEKEFFKGNIHQYGESTENNYKQAIQELK
>NZ_CP035296.1|WP_011304044.1|5064_5412_+|arsenite-efflux-transporter-metallochaperone-ArsD
MLNIEIYEEAMCCSTGVCGPEPDETLIKTNQINEYLKQNQIEVQRYNMSNNPNEFIKNKEAIRLIQEKGNEVLPITFIEGNIAKTGTYITQEEADEIITVNQMRNGGCCDGDGCC
>NZ_CP035296.1|WP_041785003.1|5392_7123_+|arsenical-pump-driving-ATPase
MEMDAVKYLNKLNLDNVELTKYLFFTGKGGVGKTTISSSIALNLAENGKKVALVSTDPASNLQDVFQMELSNKLTKYQPIPNLSIANFDPIAAADDYKAQSIEPYEGILPEDVLSEMKEQLSGSCTVEVAAFNEFTNFLSDKTLEQEFDFIIFDTAPTGHTLRMLELPSAWTDYLNTTSNDASCLGQLSGLNENRGKYNSALEKLRNQDDTTMMLVAKPSHSSIYEIQRAQQELQQLSISKFKVVINNYIEESHGLISSQMKSEQDKNINHFTEWLNNNHAYYVPYKKQKEEGIESLTNLLNDDNLIENDDFIVEDHPQFNKLTDEIENSKVQYLFTMGKGGVGKTTVATQLATALSNKGHRVLLATTDPTKEINVETTSNLNTAYIDEEQALEKYKKEVLATVNDDTPQDDIDYIMEDLKSPCTEEIAFFKAFSDIMENQEDMDYVIVDTAPTGHTLLLLDSSENHHKELKKKSTQTTSNVETLLPKIQNQDLTQMIIVTLAEKTPYLESKRLVEDLNRADIGHNWWVVNQSLVTLNQRDDLFSNKKEDESIWINKIKNESLNNYFVIPYGGLEY
>NZ_CP035296.1|WP_011304042.1|7119_8784_+|FAD-dependent-oxidoreductase
MKKIVIIGSVAAGTSVAAKARRNSEDVEITVFDKDSDISYSVCGIPYYIGGNVSDIDELTPRNAKWFKERFNIDIYTEYEVNKINDSDQTITVTNLVNDEKMIQKYDELVLATGSSPKELPQLNSEEYNNVFKVKNINDAKAIYNYINDHDVQNITIVGGGFIGLEMLEQLSNYNTSIVQRNTFMPHLDYDMSFMIQEYIEDKANVYTYNEIDIIDYDENHTINRVSLKTGELIDTDLIIIGIGVTPNTKLAKEIGINIGESGAIQTNKYLETNIPHIYAIGDAAESYNLITGNPIYRPLGSTANKMGRILGDRLTGGNLEHKGILGTGIVRIFDMTIAQTGLTEKEAVELEIDIDVLHNVKPNRPEYMQGQEMVIKAIFDKNNSKLLGAQIVGYEGVDKRIDVLATAITFGAKAEDLFHLDLAYAPPFSTTKDPVIYTGMIGHNITRGRKIITPEEVVKQKNDLLILDVRSPKQFEVDHVDGAINVPLKTLRSYAKTLDENQTIVTYCNKGTTGNAAQNVLINLGFKQVYNLSGGNKNYQRYKRFQVEREKKN
>NZ_CP035296.1|WP_002509693.1|8780_9095_+|winged-helix-turn-helix-transcriptional-regulator
MNYNEISQYLKVIADSSRLEILDLLSCGELCACDLLEHFSFSQPTLSHHMKVLKDNNLITSRKDGNKNLYKLNHDVLDDVTSRLTLLSSSTVPCICETVEKGEC

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296.1	1319-1361	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296.1	1605-1647	0	1.0

1. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to position: 1319-1361, mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

2. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to position: 1605-1647, mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	19510-19552	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	19606-19648	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	19702-19744	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	19798-19840	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	20083-20125	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046302	Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence	28074-28116	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_MN602039	Staphylococcus capitis strain APC2923 plasmid pJOS_01, complete sequence	34471-34513	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_MN602039	Staphylococcus capitis strain APC2923 plasmid pJOS_01, complete sequence	34567-34609	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_MN602039	Staphylococcus capitis strain APC2923 plasmid pJOS_01, complete sequence	34762-34804	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65379-65421	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65665-65707	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	66045-66087	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	22176-22218	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	22367-22409	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	22653-22695	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_KU882686	Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence	37712-37754	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_KU882686	Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence	37903-37945	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_KU882686	Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence	37999-38041	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	6060-6102	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	6346-6388	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	6537-6579	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1319-1361	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1605-1647	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1796-1838	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046029	Staphylococcus chromogenes strain 1401 plasmid unnamed1	35435-35477	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046029	Staphylococcus chromogenes strain 1401 plasmid unnamed1	35530-35572	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	1503-1545	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	1886-1928	0	1.0
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	19414-19456	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	19893-19935	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP027421	Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence	19988-20030	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046302	Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence	27978-28020	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046302	Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence	28169-28211	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046302	Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence	28264-28306	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046302	Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence	28359-28401	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65283-65325	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65474-65516	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65569-65611	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65760-65802	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65855-65897	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	65950-65992	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	22080-22122	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	22463-22505	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	22558-22600	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_KU882686	Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence	37808-37850	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_KU882686	Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence	38095-38137	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	6155-6197	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	6250-6292	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	6633-6675	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1414-1456	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1509-1551	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1892-1934	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046029	Staphylococcus chromogenes strain 1401 plasmid unnamed1	35721-35763	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP046029	Staphylococcus chromogenes strain 1401 plasmid unnamed1	35625-35667	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	1598-1640	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	1694-1736	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	1790-1832	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	1982-2024	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP054577	Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence	10520-10562	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP054577	Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence	10616-10658	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP054577	Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence	10712-10754	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP054577	Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence	10807-10849	1	0.977
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NC_007351	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence	22272-22314	2	0.953
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP022091	Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence	6441-6483	2	0.953
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP035296	Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence	1700-1742	2	0.953
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	22863-22905	2	0.953
NZ_CP035296_1	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	NZ_CP017461	Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence	22767-22809	2	0.953

1. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

2. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

3. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

4. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

5. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

6. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046302 (Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

7. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_MN602039 (Staphylococcus capitis strain APC2923 plasmid pJOS_01, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

8. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_MN602039 (Staphylococcus capitis strain APC2923 plasmid pJOS_01, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

9. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_MN602039 (Staphylococcus capitis strain APC2923 plasmid pJOS_01, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

10. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

11. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

12. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

13. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

14. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

15. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

16. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_KU882686 (Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

17. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_KU882686 (Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

18. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_KU882686 (Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

19. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

20. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

21. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

22. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

23. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

24. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

25. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046029 (Staphylococcus chromogenes strain 1401 plasmid unnamed1) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

26. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046029 (Staphylococcus chromogenes strain 1401 plasmid unnamed1) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

27. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

28. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 0, identity: 1.0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

29. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

30. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

31. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP027421 (Staphylococcus cohnii strain FDAARGOS_334 plasmid unnamed3, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

32. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046302 (Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

33. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046302 (Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

34. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046302 (Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

35. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046302 (Staphylococcus hominis strain FDAARGOS_747 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

36. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

37. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

38. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

39. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

40. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

41. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

42. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

43. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

44. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

45. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_KU882686 (Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

46. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_KU882686 (Staphylococcus lugdunensis strain Tlug63N-4 plasmid pT63N, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

47. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

48. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

49. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

50. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

51. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

52. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

53. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046029 (Staphylococcus chromogenes strain 1401 plasmid unnamed1) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

54. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP046029 (Staphylococcus chromogenes strain 1401 plasmid unnamed1) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaatacaaagaatatataagaatgaattaagaacaac	Protospacer
*********.*********************************

55. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

56. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

57. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

58. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

59. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP054577 (Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

60. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP054577 (Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

61. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP054577 (Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

62. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP054577 (Staphylococcus saprophyticus strain UTI-050 plasmid pUTI-050-2, complete sequence) position: , mismatch: 1, identity: 0.977

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
******************************************.

63. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NC_007351 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 plasmid pSSP1, complete sequence) position: , mismatch: 2, identity: 0.953

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
gacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
.*****************************************.

64. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP022091 (Staphylococcus saprophyticus strain FDAARGOS_355 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.953

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
gacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
.*****************************************.

65. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 (Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 = NCTC 7292 strain ATCC 15305 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.953

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
gacaaacaacacaaagaatatataagaatgaattaagaacaat	Protospacer
.*****************************************.

66. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 2, identity: 0.953

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaggaacaat	Protospacer
***********************************.******.

67. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP017461 (Staphylococcus nepalensis strain JS1 plasmid pSNJS101, complete sequence) position: , mismatch: 2, identity: 0.953

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaaaaacacgaagaatatataagaatgaattaagaacaac	Protospacer
****** *****.******************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 4536

Enterococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002448023.1\|1956_2751_+	ParA family protein	F0PIG8	Enterococcus_phage	4.3e-28	34.1
WP_002448025.1\|2756_2957_+	hypothetical protein	NA	NA	NA	NA
WP_002509686.1\|3092_3227_-	hypothetical protein	NA	NA	NA	NA
WP_011304046.1\|3240_4125_-	permease	NA	NA	NA	NA
WP_011304045.1\|4215_4536_-	winged helix-turn-helix transcriptional regulator	A0A218MNF3	uncultured_virus	1.2e-05	41.8

DBSCAN-SWA_2

8780 : 12895

Staphylococcus_phage(75.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002509693.1\|8780_9095_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	3.6e-31	60.6
WP_077460980.1\|9094_10387_+	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	2.1e-186	80.2
WP_002509695.1\|10404_10800_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	2.6e-58	82.0
WP_002508712.1\|11526_11826_+	hypothetical protein	NA	NA	NA	NA
WP_002508713.1\|11904_12117_+	hypothetical protein	NA	NA	NA	NA
WP_011304040.1\|12343_12895_+	recombinase family protein	I1ZBD6	Salisaeta_icosahedral_phage	2.9e-31	41.0

DBSCAN-SWA_3

17496 : 19614

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011304033.1\|17496_19614_-	amidase domain-containing protein	A0A0U1X189	Staphylococcus_phage	1.9e-11	46.0

DBSCAN-SWA_4

24130 : 24805

Staphylococcus_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_048787266.1\|24130_24805_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	3.4e-127	99.1

DBSCAN-SWA_5

28564 : 29239

Staphylococcus_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_048787266.1\|28564_29239_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	3.4e-127	99.1

DBSCAN-SWA_6

33852 : 36577

Pandoravirus(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011304053.1\|33852_34854_+	ThiF family adenylyltransferase	S4VW33	Pandoravirus	2.6e-06	26.6
WP_011304051.1\|35161_35410_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_011304050.1\|35410_35680_+	Txe/YoeB family addiction module toxin	NA	NA	NA	NA
WP_138936976.1\|35902_36577_-\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	3.8e-126	98.7

Anti-CRISPR protein detection

Acr_ID: NZ_CP035296.1|WP_002509686.1|3092_3227_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP035296.1|WP_002509686.1|3092_3227_-|hypothetical-protein

3092_3227_-

44 aa aa

0-4536

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP035296_1	Orphan	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	1319-1361	0
NZ_CP035296_1	Orphan	1.1\|1796\|43\|NZ_CP035296\|CRISPRCasFinder	1796-1838	43	1605-1647	0

1. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 position: 1319-1361, mismatch: 0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

2. spacer 1.1|1796|43|NZ_CP035296|CRISPRCasFinder matches to NZ_CP035296 position: 1605-1647, mismatch: 0

aacaaacaacacaaagaatatataagaatgaattaagaacaac	CRISPR spacer
aacaaacaacacaaagaatatataagaatgaattaagaacaac	Protospacer
*******************************************

3. NZ_CP035294

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP035294_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP035294_1

279974-280071

Orphan

Consensus_repeat	Method
TTGCATAAGAATCACTAAGGAAATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP035294_1

>merge|NZ_CP035294|1|279974-280071|CRISPRCasFinder
TTGCATAAGAATCACTAAGGAAATTCGTAACATTAATTTCCAAGTGAAATTAATGAATACAAAAGAAAATCTTTTGCATAAGAATCACTAAGGAAATT

>NZ_CP035294|1|1|279974-280071|CRISPRCasFinder
TTGCATAAGAATCACTAAGGAAATT	CGTAACATTAATTTCCAAGTGAAATTAATGAATACAAAAGAAAATCTT
TTGCATAAGAATCACTAAGGAAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP035294.1\|WP_011302241.1\|281585_282491_+\|cysteine-synthase-family-protein	unknown	unknown	gnl\|CDD\|107204
NZ_CP035294.1\|WP_011302238.1\|277504_278437_+\|lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|133426
NZ_CP035294.1\|WP_002482211.1\|285113_285668_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP035294.1\|WP_011302232.1\|271235_272030_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270429
NZ_CP035294.1\|WP_011302240.1\|280078_281368_-\|homocysteine-synthase	unknown	unknown	gnl\|CDD\|225428
NZ_CP035294.1\|WP_011302231.1\|270675_271002_+\|PTS-lactose/cellobiose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|376749
NZ_CP035294.1\|WP_011302236.1\|275545_276301_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP035294.1\|WP_077461027.1\|278602_279673_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP035294.1\|WP_002482190.1\|272729_273461_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP035294.1\|WP_002482214.1\|286782_287625_-\|urease-accessory-protein-UreD	unknown	unknown	gnl\|CDD\|223899
NZ_CP035294.1\|WP_002482186.1\|270344_270665_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99906
NZ_CP035294.1\|WP_011302248.1\|288253_288943_-\|urease-accessory-protein-UreF	unknown	unknown	gnl\|CDD\|223900
NZ_CP035294.1\|WP_011302249.1\|288935_289388_-\|urease-accessory-protein-UreE	unknown	unknown	gnl\|CDD\|237322
NZ_CP035294.1\|WP_011302237.1\|276642_277461_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP035294.1\|WP_011302233.1\|272013_272733_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP035294.1\|WP_011302245.1\|285841_286312_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
NZ_CP035294.1\|WP_011302242.1\|282487_283633_+\|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase	unknown	unknown	gnl\|CDD\|181076
NZ_CP035294.1\|WP_011302246.1\|286489_286696_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP035294.1\|WP_011302235.1\|274414_275332_-\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|183829
NZ_CP035294.1\|WP_011302247.1\|287625_288240_-\|urease-accessory-protein-UreG	unknown	unknown	gnl\|CDD\|349776

Protein	Function_ID	Function_description	E-value
NZ_CP035294.1\|WP_011302241.1\|281585_282491_+\|cysteine-synthase-family-protein	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	4.24084e-110
NZ_CP035294.1\|WP_011302238.1\|277504_278437_+\|lactate-dehydrogenase	gnl\|CDD\|133426	cd05290, LDH_3, A subgroup of L-lactate dehydrogenases. L-lactate dehydrogenases (LDH) are tetrameric enzymes catalyzing the last step of glycolysis in which pyruvate is converted to L-lactate. This subgroup is composed of some bacterial LDHs from firmicutes, gammaproteobacteria, and actinobacteria. Vertebrate LDHs are non-allosteric, but some bacterial LDHs are activated by an allosteric effector such as fructose-1,6-bisphosphate. LDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenase, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	8.30515e-159
NZ_CP035294.1\|WP_002482211.1\|285113_285668_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.36006e-12
NZ_CP035294.1\|WP_011302232.1\|271235_272030_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.32092e-109
NZ_CP035294.1\|WP_011302240.1\|280078_281368_-\|homocysteine-synthase	gnl\|CDD\|225428	COG2873, MET17, O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism].	0
NZ_CP035294.1\|WP_011302231.1\|270675_271002_+\|PTS-lactose/cellobiose-transporter-subunit-IIA	gnl\|CDD\|376749	pfam02255, PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.	1.9317e-36
NZ_CP035294.1\|WP_011302236.1\|275545_276301_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.72315e-10
NZ_CP035294.1\|WP_077461027.1\|278602_279673_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	8.29114e-23
NZ_CP035294.1\|WP_002482190.1\|272729_273461_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.94086e-142
NZ_CP035294.1\|WP_002482214.1\|286782_287625_-\|urease-accessory-protein-UreD	gnl\|CDD\|223899	COG0829, UreH, Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones].	1.83725e-86
NZ_CP035294.1\|WP_002482186.1\|270344_270665_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99906	cd05564, PTS_IIB_chitobiose_lichenan, PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	2.16723e-45
NZ_CP035294.1\|WP_011302248.1\|288253_288943_-\|urease-accessory-protein-UreF	gnl\|CDD\|223900	COG0830, UreF, Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones].	1.45042e-91
NZ_CP035294.1\|WP_011302249.1\|288935_289388_-\|urease-accessory-protein-UreE	gnl\|CDD\|237322	PRK13261, ureE, urease accessory protein UreE; Provisional.	1.24412e-59
NZ_CP035294.1\|WP_011302237.1\|276642_277461_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	6.23317e-97
NZ_CP035294.1\|WP_011302233.1\|272013_272733_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	6.40669e-78
NZ_CP035294.1\|WP_011302245.1\|285841_286312_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	5.61813e-26
NZ_CP035294.1\|WP_011302242.1\|282487_283633_+\|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase	gnl\|CDD\|181076	PRK07671, PRK07671, bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase.	0
NZ_CP035294.1\|WP_011302235.1\|274414_275332_-\|2-dehydropantoate-2-reductase	gnl\|CDD\|183829	PRK12921, PRK12921, oxidoreductase.	1.47135e-125
NZ_CP035294.1\|WP_011302247.1\|287625_288240_-\|urease-accessory-protein-UreG	gnl\|CDD\|349776	cd05540, UreG, urease accessory protein UreG. UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.	1.54103e-117

>NZ_CP035294.1|WP_077461027.1|278602_279673_+|ROK-family-protein
MLERHVKLIRLMLINRNQFLNADEIARYLNVSNRTARNDIQYINSEILDDLIVSVKGRGYKLNQSLYSMQQIETIVTDFTNKESELLIKLGYQLLMYQQPLTSEAIGKTFHLTKAEVTDYINKIKAWCISFDVNIQITKKKGITVNGSEMNIRNAILHLNQLSENVKTVDAFILAEHQYMKHQTEDFIYLTISTGVGMAYIRKGELVSGVNGNFGEIGHTIIKGDSDYQCPVCKQYVCVENEISGLAISRKASHILNKHVSTREAIEMYLHQAHSEITEMIDEVLILTQQLCTNLFSIFNINNIVLGGGVTQSKLPYKSSIENYAQKHYLIQNSTLNVTISNLEANVLTGLYHVNK
>NZ_CP035294.1|WP_011302238.1|277504_278437_+|lactate-dehydrogenase
MSKLGIIGLGKVGTQVLTDVQQLNLFSEIILIDDRADVASGEALDHIHSQGLINTAHIKIRSGVYQDLTDADFIVIAASEATDKNNGDRTLLAQGNHDIIKGIMSQIAEVTQEAVVILISNPVDSMVYFANQIDYPAHKIIGTGTALETSRFKTIIADHYQIDPNNVEAFVIGEHGQHAIPVWSKVHIHGMELSEFEALSDRPAIDKSHISSIINEVSMDVFYQKGWTNAAISKVTSFLIQSIALDQRTITPLTSLSSEYGLEDGAFSLPTLIDKKGIVQRFAITLDKEEERELKEAYEYIRQTIHTAQQ
>NZ_CP035294.1|WP_011302237.1|276642_277461_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MRKWFILGSLFVLTIILAACGKSNGEKEDKEITIAASPAPHGVVLEHAKEEMKKKGYDLKIKTVNDYKVPNKLLDKGDVDANAFQHTPYLKAEKKDHNYKIEEAGKVFTTPMGVYSKKYKDIKDIPKGSTIYVSNNPAEEGRFLSFFVDKGLIKIKKGVSIEDAKFDDIVENKKDLKFNNKQGAEFLPKTYNSKEGAAVIMNSNYAIDNGLTPHKDAIAIEGKSSPFANIVAVQEGHKNDKKFKELMKVLQSKEMKKFITDKYGQDVIPYEK
>NZ_CP035294.1|WP_011302236.1|275545_276301_+|CPBP-family-intramembrane-metalloprotease
MSFKNDHKYQWKDMQGKDFLLPFIYLIGNFCLSIVILTIMIGINETQGKNNANFNANFSGTPGILMEMIAFIIIFALWILFHRHSFRQSWKQGLQNIKQHWKLIVITFIVIIVFKEIYPYLVNAFAPEHWKFEETQNDKMVEEMFATPVSTILAFFSIVIIAPMTEEFLFRHLIIGELGKKLNFYVMSVISIIVFASLHVTEAKSPLEIVMYLAIAVGIVYVYMKSQRSLAVAIALHALNNLLAYIFMIIM
>NZ_CP035294.1|WP_011302235.1|274414_275332_-|2-dehydropantoate-2-reductase
MRILVLGAGGIGGYFGGRLAESGQNVTFLVRPKRKSFLERNGLAIHSEQGDYHFNPQLITKDDRVAPFDVILLSSKSYHLEQAMTDLKPFVDGHTAIIPLLNGVAHIPQLQSIFGKDKVMGGYCVIETTLDSMGEIIQTSPFDKLFFGELDGSKSERAQKIAQAFSETKAEFKLSTSIEQGMWHKYLMITVLSSITTLMHAPIGPIRDSDGGINFVRSLYNEVASIMRAHRAPLADDIVSQYMTSFNQLSYHFKTSMQRDMEKGLNIETGHLQGYLLNLADTYQIDAPLLKCVYQNHKVYKEMLK
>NZ_CP035294.1|WP_002482190.1|272729_273461_+|amino-acid-ABC-transporter-ATP-binding-protein
MIELKNIKKSFDDKEVIKGIDLNVNQGEVVTFIGRSGSGKTTLLRMINALELPTEGAVYVNGETYSNADKKSQIKVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKTKKDEAKQQALALLEKVDLTAVKDQRPNALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLRVIKDLANEGMTMIIVTHEMRFAKEVSNKIVFIHDGVIGESGPPEQIFNHPQSAELQRFLNMIREV
>NZ_CP035294.1|WP_011302233.1|272013_272733_+|amino-acid-ABC-transporter-permease
MFLNLNTEQQHALDAAGQAFAPMLEGLVKFSIPITLVTFLLGLVIALLTALMRISTSRILRGIARFYISIIRGTPMIVQLFIIFYGIPELGRLLTNNSENQWTLAPVIAAIIGLSLNVGAYASEIIRGGIMSIPKGQTEAAYSIGMNYRQTIQRIILPQAIRVSVPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYLLVALMYWVVCFIISIAQNFYESYLERGYRS
>NZ_CP035294.1|WP_011302232.1|271235_272030_+|amino-acid-ABC-transporter-substrate-binding-protein
MKKILLGILTLLLVVGLAACGTSDKKDNDNKNKTASENKTFVVGTEGTYAPFSYHDKQDKLTGYDIDVMKAVAKEMGYKVKFKETQWDSMFAGLDSGRFNVIANQVGINDERKEKYKFSEPYTYSEAVLVVNKNNKDIKSFDDVKGKKLAQTFTSNYGKLAKSKGAELTKVDGFNQAMDLLQSNRVEGTFNDNISYLDYKKQKPNADVKIIEGNAEKSQSALTFSKKEDDATIEKVNKAMKKLKDNGELAKISKKWFGEDVSKS
>NZ_CP035294.1|WP_011302231.1|270675_271002_+|PTS-lactose/cellobiose-transporter-subunit-IIA
MSEAENSLEFAMSLIAYSGDAKSHAMEAIYAAKKNAFEEAEKKLKLAEVSLLEAHHIQTNMLTKEAQGDEIKMSLLTIHSQDHLMTAITFKDMAAEMIDLYKKMDSKA
>NZ_CP035294.1|WP_002482186.1|270344_270665_+|PTS-sugar-transporter-subunit-IIB
MAEKTIMLVCAAGMSTSMLVQKMQKEAEKQKLDRDIFAVSTSEADQKIESDNIDVLLLGPQVRFKKDEYTKKCSEKDIPVAVIEMRDYGTMNGENVLNTAEQLMTK
>NZ_CP035294.1|WP_011302240.1|280078_281368_-|homocysteine-synthase
MTQNPWHLDTLSIHGGQVVDDFSKARAVPIYQTSSYVFDNTEHARKLFALEEDGNIYTRIMNPTQNVFEERIAALEGGVGALATSSGQAAIHLALLNIVESGDEIVASSNLYGGTYNLLNITFKKLGIKVHFVDPSHPDNFKNAITDKTKAVYAETIGNPRIDVLDIEAVADIAHNHNIPLIVDNTFPTPYLLRPFEFGADIIVHSATKFIGGHGTSIGGVIVDSGKFNWDNGKFPGLVEPDESYHGISYAKDVGEAAYITKARVQLLRDLGSAVSPFNVHEFLIGLETLHLRLERHSENALRVAQYLEQHPKVTWVNYPGLKNNAYHQLAQKYLPDGQGAILTFGIDGTVDDIAKFVDGLNLFSHLANVGDSKSLIIHPASTTHLQLSPEDQKASGVVPELVRLSVGTENINDIIADLDNGFKESLGN
>NZ_CP035294.1|WP_011302241.1|281585_282491_+|cysteine-synthase-family-protein
MIAFDLIGNTPLVLLESFSNKDVQIYAKLEQYNPGGSVKDRLGKHLIETAIRENIIQKGDVVVEASAGNTGIGVAIAANHYGVSAVIFAPEGFSEEKISIIKALGAEVIRTDQTLGMAGAQKAARDYELQTGAYYLNQFESYRNPETYKSTIGKEITDKLKDIDYFVGGVGSGGTFTGVAEHLAATYHTESVIVEPEGSILSGGNAHSHDIEGIGSEKWPSFLPKALVSDIIKVSDDAAFQNVKLLARQEGLLVGSSSGAALQGALEIKKHINKGVIVTIFPDGSDRYMSKQILNYKETIK
>NZ_CP035294.1|WP_011302242.1|282487_283633_+|bifunctional-cystathionine-gamma-lyase/homocysteine-desulfhydrase
MNKKTQLIHGGQTTDPYTGAVTTPIYQTSTYMQDGIGDMRQGYEYSRSANPTRSALEGLIADLEQGESGFAFGSGMAAISAVIMLLDKGDHLLINSDVYGGTYRALTKVFNRFGIDAEFIDTTNIEAVEQYIKPETKMLYIETPSNPLLRVTDIKKSAEIAKKHHLISVVDNTFMTPYFQNPLTLGIDIVLHSATKYIGGHSDVVAGLVATSDAELAERLGFIQNSTGGVLGPQDSYLLIRGIKTLGLRMEQVQRNTLAIIDMLQQHSAVKQVFHPSISDHLNHDIHEAQSEGHTGVVAFEVADIESAKKVISESHYFTLAESLGAVESLISVPALMTHASIPKDIREKEGIADGLVRLSVGIEDTKDLVEDLEQSLNALG
>NZ_CP035294.1|WP_002482211.1|285113_285668_-|TetR/AcrR-family-transcriptional-regulator
MSQKKQDILSVAERLFYEYGFKGVGLKQIIQEANVATMTLYNHFESKDNLVAQVLKQRETRYWHYLDSHVEQHPEKPFISAVTAHCQWLNDYSYKGDMFMRAIEDYADTDNEIESTARGHKERLLHYLEKLADDAGIENGYDLAVQYTLLLEGTTSMTALLGSKDATSHAITMAKLLLNEAHNQ
>NZ_CP035294.1|WP_011302245.1|285841_286312_-|acyl-CoA-thioesterase
MTDEYIYKNTVQPSWIDNNNHMHDAQYYSIFSDAVVGFFESIDFSTDYRHSQDVTMFSVEAHISFLKELLLDESFYIKVHIYDYDAKRVHLFLTMYNSNDERNATYEAIMMGVGNETRRSMDFPKPIQEKIKHYFDQQNTFDVPKQLGHVIGIPKK
>NZ_CP035294.1|WP_011302246.1|286489_286696_+|hypothetical-protein
MVLVALILFIISIVFLIYSITLLMGKDGTMFSLFTKEEKALTKGQKLTIYLITIVLFVASLVWLLNLI
>NZ_CP035294.1|WP_002482214.1|286782_287625_-|urease-accessory-protein-UreD
MSNNKQAWTGQLDLSVFNNGKKSVARDVFFEKALKVMRPVYLNQSDIPTFYIVNVGGGYLDGDRYTMNFNIDSDAKVILTSQGATKIYKTLNDHVEQYQTFNIKNNGYAEYVGDPIIAFENAKFYQHNVFNLESTASLFYTDILTPGYSKSDKRFSYTYMHLLNEIYVDDALVTFDNMLLDPQKQNVDGLGYMEDYTHLGSCYFIHPSVNQKFIEQVYEEIKHFQHKYDCRFGITHLPTHGFSLRILSNKTQVIESIITAVQCYVVKQIFDRDVDFLRKY
>NZ_CP035294.1|WP_011302247.1|287625_288240_-|urease-accessory-protein-UreG
MTDTIKIGVGGPVGAGKTQLIEKIVKRLAKDMSIGVITNDIYTKEDEKILVNSGVLPEDRIIGVETGGCPHTAIREDASMNFAAIDELKERNDDIELIFIESGGDNLAATFSPELVDFSIYIIDVAQGEKIPRKGGQGMIKSDFFVINKTDLAPYVGASLDRMAEDTKVFRGNRPFTFTNLKTDEGLDEVIQWIEQDVFLKGLA
>NZ_CP035294.1|WP_011302248.1|288253_288943_-|urease-accessory-protein-UreF
MIDHAHLRLFQFCDSQFPTGAFSHSFGLETYIQRDTVHDEESFQQWLVLFLNEQLTYADGLTMRLVYDALNENDTKAILKLDRILFVQNLPKETRQGSKQMGNRMVKLASELYDSDWINWYHAQMKDKKASLHPAICFTMLGHHLGVDIETIIDYYLYQNVSSLTQNAVRAIPLGQTAGQRIVHKMIPIMKETRDHIMTIPASQLGITAPGLEINQMEHENVNVRIFIS
>NZ_CP035294.1|WP_011302249.1|288935_289388_-|urease-accessory-protein-UreE
MIIEEIVGNIANFSDSEKGKHMEKVYLENSDLVKRIQRVTTDHGNEIGIRLKQPIDLQYGDILYKDDKNMIVVDVNSEDLLVIKPRTLQEMGDIAHQLGNRHLPAQFTETEMLVQYDYLVESLLKDLGIPYEHEDRKVNKAFRHIGHSHD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1004757 : 1019063

Staphylococcus_phage(92.31%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041784790.1\|1004757_1006140_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	5.3e-167	61.3
WP_011302825.1\|1006159_1007164_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	2.9e-90	49.4
WP_011302826.1\|1007153_1007405_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	4.2e-30	81.1
WP_011302827.1\|1007464_1007941_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	4.8e-43	53.5
WP_041784896.1\|1007948_1008716_+	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	4.8e-101	71.8
WP_011302829.1\|1008811_1010401_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	8.5e-262	81.8
WP_011302830.1\|1010789_1011986_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.8e-195	86.6
WP_011302831.1\|1012084_1012993_+	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	1.1e-101	75.8
WP_011302832.1\|1013162_1013999_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	4.2e-111	68.2
WP_011302833.1\|1014269_1014626_-	CrcB family protein	NA	NA	NA	NA
WP_011302834.1\|1014622_1014988_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.3e-36	62.8
WP_011302835.1\|1015198_1015504_-	hypothetical protein	NA	NA	NA	NA
WP_011302836.1\|1015788_1016502_+	transaldolase	E3SKN5	Synechococcus_phage	2.9e-20	36.3
WP_011302838.1\|1017618_1018068_+	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	1.3e-21	47.5
WP_011302839.1\|1018075_1018501_-	competence protein ComK	NA	NA	NA	NA
WP_103314713.1\|1018514_1019063_-	sigma-70 family RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	2.6e-24	43.7

DBSCAN-SWA_2

1023431 : 1033568

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011302847.1\|1023431_1024898_+	FAD/NAD(P)-binding protein	A0A2H4PQX2	Staphylococcus_phage	5.5e-13	58.6
WP_011302848.1\|1025439_1026483_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	1.0e-130	64.4
WP_011302849.1\|1026489_1027122_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	5.0e-72	64.8
WP_011302850.1\|1027133_1028315_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	4.2e-165	71.2
WP_002482978.1\|1028328_1028787_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	6.6e-58	76.3
WP_011302851.1\|1029051_1030053_-	proline dehydrogenase family protein	A0A2H4PQT6	Staphylococcus_phage	7.3e-126	68.5
WP_011302852.1\|1030319_1031144_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_011302853.1\|1031379_1032336_+	L-lactate dehydrogenase	NA	NA	NA	NA
WP_002482982.1\|1032487_1032889_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_011302854.1\|1033007_1033568_-	class I SAM-dependent methyltransferase	A0A2H4PQV0	Staphylococcus_phage	9.5e-67	63.8

DBSCAN-SWA_3

1162212 : 1171338

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002483095.1\|1162212_1163217_+	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.9
WP_011302949.1\|1163219_1164245_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_011302950.1\|1164265_1165411_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	2.5e-85	45.0
WP_011302951.1\|1165426_1165687_+	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	7.4e-06	44.1
WP_011302952.1\|1166069_1168346_+	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.7e-29	34.6
WP_011302953.1\|1168527_1170807_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	3.8e-69	29.4
WP_002483102.1\|1170819_1171338_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	6.6e-30	46.2

DBSCAN-SWA_4

1297642 : 1307610

uncultured_Mediterranean_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002483230.1\|1297642_1298530_+	site-specific tyrosine recombinase XerD	A0A0K2CP59	Brevibacillus_phage	5.1e-38	31.4
WP_011303058.1\|1298598_1299105_-	DUF309 domain-containing protein	NA	NA	NA	NA
WP_011303059.1\|1299196_1299931_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	1.4e-09	23.5
WP_002483233.1\|1299914_1300463_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	2.1e-10	31.4
WP_002483234.1\|1300455_1301193_+	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_011303060.1\|1301319_1302045_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.1e-46	42.6
WP_041784899.1\|1302028_1303792_+	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	1.7e-21	23.8
WP_037538408.1\|1304219_1304765_+	ECF transporter S component	NA	NA	NA	NA
WP_002483238.1\|1304920_1305169_-	ferredoxin	A0A127AYY7	Bacillus_phage	4.9e-15	48.0
WP_011303062.1\|1305278_1306238_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_011303063.1\|1306230_1307610_+	ATP-dependent DNA helicase RecQ	M1PGQ0	Moumouvirus	7.1e-55	32.4

DBSCAN-SWA_5

1785982 : 1794457

Synechococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011303433.1\|1785982_1786549_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	9.7e-27	38.2
WP_011303434.1\|1786551_1787580_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.6e-67	44.5
WP_011303435.1\|1787572_1789060_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.6e-44	31.7
WP_011303436.1\|1789038_1791228_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.4e-137	39.6
WP_011303437.1\|1791220_1791892_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_011303438.1\|1791891_1792152_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_011303439.1\|1792154_1792856_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SE76	Cyanophage	6.8e-46	42.5
WP_011303440.1\|1792860_1793988_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_011303441.1\|1793974_1794457_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.6e-20	44.0

DBSCAN-SWA_6

2029683 : 2048413

uncultured_Caudovirales_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011303647.1\|2029683_2030652_-	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	2.6e-136	78.3
WP_002483928.1\|2031065_2032034_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	2.2e-175	94.4
WP_011303648.1\|2032157_2034263_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	89.9
WP_002483930.1\|2034225_2034624_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	8.6e-54	76.5
WP_011303649.1\|2035350_2036238_+	DMT family transporter	NA	NA	NA	NA
WP_002483932.1\|2036251_2036752_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	2.0e-52	72.3
WP_011303650.1\|2036934_2038449_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	9.5e-69	35.8
WP_011303651.1\|2038819_2040325_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	6.3e-65	32.2
WP_011303653.1\|2040794_2041742_+	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	1.5e-11	23.6
WP_002483937.1\|2041912_2042461_-	5'-3'-deoxyribonucleotidase	A0A0A0PKY7	Bacillus_phage	2.0e-29	39.0
WP_011303654.1\|2042638_2043694_-	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.3e-21	27.2
WP_002483939.1\|2043852_2045370_-	ABC transporter permease/substrate-binding protein	NA	NA	NA	NA
WP_011303655.1\|2045366_2046329_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.8e-26	32.5
WP_011303656.1\|2046634_2048413_-	DNA helicase RecQ	M1PGQ0	Moumouvirus	5.9e-78	36.8

DBSCAN-SWA_7

2056716 : 2064266

Pandoravirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011303663.1\|2056716_2057859_-	aminodeoxychorismate synthase component I	S4VNU7	Pandoravirus	5.4e-24	36.7
WP_011303664.1\|2057842_2058436_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.9e-36	41.5
WP_002483950.1\|2058691_2059363_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	1.2e-63	54.9
WP_011303665.1\|2059364_2059790_+	6-carboxytetrahydropterin synthase QueD	NA	NA	NA	NA
WP_002483952.1\|2059782_2060499_+	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	2.5e-51	43.4
WP_011303666.1\|2060739_2061333_+	hypothetical protein	NA	NA	NA	NA
WP_002483954.1\|2061401_2061653_+	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
WP_011303667.1\|2061870_2062932_-	glycosyltransferase family 2 protein	A0A192Y8W7	Salmonella_phage	8.7e-61	42.3
WP_002483956.1\|2063426_2064266_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	1.2e-52	40.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP035297

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP035296

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

3. NZ_CP035294

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection