CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP035103	Kocuria rosea strain ATCC 186 chromosome, complete genome	3 crisprs	csa3,DEDDh,WYL,DinG,cas3	1	1	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP035103_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP035103_1

526270-526363

Orphan

Consensus_repeat	Method
CGGGAACGCCCCGAGGACGACGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP035103_1

>merge|NZ_CP035103|1|526270-526363|CRISPRCasFinder
CGGGAACGCCCCGAGGACGACGAGGAAGTCATCACCGCGGTGCTGGCCGCCGTCAGCCACCGCTCCTCCCGGGAACGCCCCGAGGACGACGAGG

>NZ_CP035103|1|1|526270-526363|CRISPRCasFinder
CGGGAACGCCCCGAGGACGACGAGG	AAGTCATCACCGCGGTGCTGGCCGCCGTCAGCCACCGCTCCTCC
CGGGAACGCCCCGAGGACGACGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP035103.1\|WP_035925293.1\|531505_532531_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP035103.1\|WP_035925626.1\|530809_531457_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP035103.1\|WP_109269197.1\|528711_529302_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP035103.1\|WP_109244246.1\|530218_530671_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP035103.1\|WP_109269191.1\|523080_523713_-\|deaminase	unknown	unknown	gnl\|CDD\|223340
NZ_CP035103.1\|WP_109269195.1\|526443_527619_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|225118
NZ_CP035103.1\|WP_109269193.1\|525219_525768_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP035103.1\|WP_109269190.1\|520574_521756_-\|lipase	unknown	unknown	gnl\|CDD\|238881
NZ_CP035103.1\|WP_017834030.1\|530032_530215_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP035103.1\|WP_109269192.1\|523858_525118_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP035103.1\|WP_109269186.1\|515866_516436_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100047
NZ_CP035103.1\|WP_017834026.1\|532708_534007_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NZ_CP035103.1\|WP_109269187.1\|516511_517153_-\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238496
NZ_CP035103.1\|WP_109221871.1\|517312_518281_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP035103.1\|WP_035925296.1\|534072_534441_-\|L-rhamnose-mutarotase	unknown	unknown	gnl\|CDD\|377501
NZ_CP035103.1\|WP_109269244.1\|521793_522867_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176235
NZ_CP035103.1\|WP_109244245.1\|529463_529949_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	unknown	unknown	gnl\|CDD\|379804
NZ_CP035103.1\|WP_109269196.1\|527695_528715_+\|arsenic-resistance-protein	unknown	unknown	gnl\|CDD\|223869
NZ_CP035103.1\|WP_109269189.1\|518945_520277_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP035103.1\|WP_109269188.1\|518378_518945_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379450

Protein	Function_ID	Function_description	E-value
NZ_CP035103.1\|WP_035925293.1\|531505_532531_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.39069e-100
NZ_CP035103.1\|WP_035925626.1\|530809_531457_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	7.97417e-18
NZ_CP035103.1\|WP_017834026.1\|532708_534007_-\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.21843e-37
NZ_CP035103.1\|WP_109244246.1\|530218_530671_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.67297e-13
NZ_CP035103.1\|WP_109269191.1\|523080_523713_-\|deaminase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	2.61614e-11
NZ_CP035103.1\|WP_109269195.1\|526443_527619_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|225118	COG2208, RsbU, Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription].	6.17602e-36
NZ_CP035103.1\|WP_109269193.1\|525219_525768_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	2.44976e-16
NZ_CP035103.1\|WP_109269190.1\|520574_521756_-\|lipase	gnl\|CDD\|238881	cd01844, SGNH_hydrolase_like_6, SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	3.92987e-62
NZ_CP035103.1\|WP_017834030.1\|530032_530215_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	5.03164e-14
NZ_CP035103.1\|WP_109269192.1\|523858_525118_-\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.30459e-19
NZ_CP035103.1\|WP_109269186.1\|515866_516436_+\|acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	6.33376e-59
NZ_CP035103.1\|WP_109269187.1\|516511_517153_-\|isochorismatase-family-protein	gnl\|CDD\|238496	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.	3.94277e-42
NZ_CP035103.1\|WP_109221871.1\|517312_518281_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	8.57414e-100
NZ_CP035103.1\|WP_035925296.1\|534072_534441_-\|L-rhamnose-mutarotase	gnl\|CDD\|377501	pfam05336, rhaM, L-rhamnose mutarotase. This family contains L-rhamnose mutarotase which is a glycosyl hydrolase that converts the monosaccharide L-rhamnopyranose from the alpha to the beta stereoisomer. In Escherichia coli this enzyme is the product of the rhaM gene (also known as yiiL). The tertiary structure has been solved, in complex with L-rhamnose, and the catalytic mechanism determined. His22 is the proton donor. The enzyme naturally exists as a dimer.	2.87202e-31
NZ_CP035103.1\|WP_109269244.1\|521793_522867_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176235	cd08274, MDR9, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.67009e-158
NZ_CP035103.1\|WP_109244245.1\|529463_529949_+\|pyridoxamine-5'-phosphate-oxidase-family-protein	gnl\|CDD\|379804	pfam16242, Pyrid_ox_like, Pyridoxamine 5'-phosphate oxidase like. This domain, approximately 140 residues in length, is mainly found in general stress proteins in various Xanthomonas species. It is composed of a six-stranded antiparallel beta-barrel flanked by five alpha-helices and can bind to FMN and FAD, suggesting that it may help the bacteria to react against the oxidative stress induced by the defense mechanisms of the plant.	2.10539e-48
NZ_CP035103.1\|WP_109269196.1\|527695_528715_+\|arsenic-resistance-protein	gnl\|CDD\|223869	COG0798, ACR3, Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism].	3.89251e-41
NZ_CP035103.1\|WP_109269189.1\|518945_520277_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	5.46123e-53
NZ_CP035103.1\|WP_109269188.1\|518378_518945_+\|hypothetical-protein	gnl\|CDD\|379450	pfam14067, LssY_C, LssY C-terminus. This domain is found at the C-terminus of Legionella LssY proteins, which may be a part of the type I secretion system. This domain is functionally uncharacterized. This domain is found in bacteria, and is typically between 182 and 195 amino acids in length. It is often found in association with pfam09335 and PF01569. There are two completely conserved residues (P and W) that may be functionally important.	2.61966e-10

>NZ_CP035103.1|WP_109269193.1|525219_525768_+|Lrp/AsnC-family-transcriptional-regulator
MLAELITLIKSWRRTTDRETTVTTLDAVDIGLLLHLLRYPRAQIGEVAAALGVARNTVVSRMRRLERREVLRSGGRDVDLTSVGFDVLAFLTLEVTHRELDAVVTALRGIDNVLEVHEISGRGDVWCRVAARETRDLHAVLRSILRIRGVLRAETSLALSEQIPYRVQPLLRTLTKGDSTSA
>NZ_CP035103.1|WP_109269192.1|523858_525118_-|MFS-transporter
MTVFNELTMRSGAGDAGRGWNAGSRSRLVLTMSTTALLLVGANLATPLYPALQERLGLGPFAVTVAFSSYVLALIAGLVLYGHWSDHIGRRTALVLSVLVGLAGEIVFATAGGLAGLVTGRVLQGAAVAMVTGASSAALRELLPHRPEWAGRFTLLASAGGVAAGPLLGGALGQLPHPTTTPFAVHCTMLIAVLVPLWTLHARPAIAPAPGSAAFKALRPRRLCLPPGVRTRFQQAAAVGFLSFALFGFSLSLAPGYFARTLGVSSPAGIGALAALVLIGSAAAQLVGRPRVRALPGALVGMALGTALIGVAGALSSLPLLLLGALFAGAAQGVAFRTAFNELSVAVPAADNARVVSAVYVVTYLGSAVPVLGLGVLAGAVGVPSSVHWFAGTLAGACLLLAGTVRLRARRGPRRGQQA
>NZ_CP035103.1|WP_109269191.1|523080_523713_-|deaminase
MSRARVHNFSISLDGFGTGEGLSQDAPFGHAGQRLHEWMIATRWWDPGGSGGVDDAFAQLHGVGIGAEIMGAGKFGPPGWHEDPGWEGWWGPNPPFHTPVFVLTHFPRPSIEMEGGTVFHFIDASPAEALETARTAADGQDVRIGGGPTTVRDFLAAGLVDHLHVVVVPILLGRGVRLWEGLEGLEADYRVEATSAPRGVTHVTFTRTSA
>NZ_CP035103.1|WP_109269244.1|521793_522867_-|zinc-binding-dehydrogenase
MTAVVTTGVGGYDRLVLSRVPIPEPGEGEVLVRVLAAGMNNTEINTRLGWYSSSVTAGTNDVSEDAVGDASTRPDGGWNAATPFPLIQGADCCGRIAAVGRGGDESALGARVLVRACMRTKGFSSWDTTWLGSDLDGAFAQFVVVPAHEVFPVDCDWSDAELATIPCAYGTAENMVRRAGVTTGARVLVTGASGGVGSAVVQLAKRRGAHVVGMAGDAKRDQVRALGADEVVGRDDPRDVLGADSVDVVVDNVAGPGFPAVLDLLRRGGTYVSSGAIGGPLVALDMRTLYLKDLTLIGCTAWDEEVFPDLVSYIERGEIRPLLARVFPLEQIAAAQREFLEKTHVGKFALIPPDPAP
>NZ_CP035103.1|WP_109269190.1|520574_521756_-|lipase
MPIPDRHCTTPVTDELLHGVVELEHTDDGVIPHRLPAWARNQARDPQLAMAESQPSGARLLFATEARRIELRGRATRFRYEGAPPRPAGVFDLLVDGQRTRQAGLEAATVVSIDMTTGDRQITQAGIGGVVFDDLPRGPKTVELWLPHNETVELAEISSDAPLRPVQDLRPRWVHHGSSISHGSNAVHPTGTWPAVAARRADLNLLNLGFGGSALLDPFTARTIRDTPAELISVKLGINLVNLDLMRLRALGPAVHGFLDTIRDGHPHTPLLVISPLLCPIHENTPGPGAFDPDALARGELRFRATGDPGEVAAGKLTLTVIRAELARIVTERAHDDPHLFHLDGRELYGESDARELPLPDALHPDATTHLRIGERFAEFVLGHGSLPAGEGA
>NZ_CP035103.1|WP_109269189.1|518945_520277_-|serine-hydrolase
MSAPARSTRRTFAAATAAALLLGTTGGATAAPPSPAGPAATPVAAAAPSAPATDSEACVTDVDDVVTREPSAQMSEPLPEELATTLDAAARASFAQASTPGAVVGVSSPEGTWTAAYGVADPATGEPMEVGVHTRVGSVTKPFTATLVLQLAEEGELSLEDPIADYVDGIPNGEQITLRRLADMTSGVASYTRSTQFTDRFFADPQQVFTPEELVAVGVSESPQFAPGAQFDYSNTNYILLGLVVEQVTGQPIGEVLEEQIFDPLELDETVWPGTSTEMPEPYAQGFTLQGDTATPEAPADATHWNPSWGATAGALISDVDDLLTYGRALGTGHGLLEPEAQRERLTSFQPPESGYGLGFGCIDGWVGHTGTQPGYNTTVYYDTTTDTTVVVQATSDIPSGDCPESPVLADDPRTLPCATPATRIFAEVSAALGHTFTPNPER
>NZ_CP035103.1|WP_109269188.1|518378_518945_+|hypothetical-protein
MDAGRGRPDSDERSPQPKGGARRATVVLWAHRFGFLVTSVLAGWGVYHLVLEEIDDDGRLPWLFLPLWVLSAYVLLPRLNRLLTGIYVPSYFIGRARTSDGLLGDPVNLAVVGTPAQLSAAMVGAGWTAADTDRERDLVVSSLQAVGATVHVVEQYSTGYHARNGGGDAIETDGDLPVIDVRPIRWSG
>NZ_CP035103.1|WP_109221871.1|517312_518281_+|helix-turn-helix-domain-containing-protein
MRIAIHAFEGVTMFHLAVPQLVFGEVTRLGLAEGWDTVLWSTGADMITTAEGYSLGRLAGPEAAEDADLVVIPSWPYPPVAVDEPLRAVLTRAHAHGSGVVGLCMGAFAVAEAGLLGGRPAVTHWEGMDELASRHPELAVEDSVLYIDHDDVMTSAGTASSLDACLHLVRKHLGAAAANRVARSLVVAPHREGGQAQYIQRPVARPDSGDPLAATLDWAMARLHEPLSIDELAAHARMSRRTLVRRFRDTTGTTPARWVLARRLDEARSLLETTRWGVDRIALACGFGSAVTLRQNFVSAYATTPSAYRRSFALREAGGDSR
>NZ_CP035103.1|WP_109269187.1|516511_517153_-|isochorismatase-family-protein
MTIPRRALIVVDAQMEYFDGPMSIQYPPREESLANIGRVLEVAAEQDMPVVMVQHETDEGAPIFAPGSTGYPLHPDLEQLDNRQWKQVVKGYGSVFAGTDVAEWLRERDVDTITIVGYMTNNCDLATAVEAEGLGFAAEILSDATGAIHLANEAGQVSAEDLHRTLMVLLQSNFAAVTATDAWIGAVAGGESPVRSNLVASAMNGAEAFTSGS
>NZ_CP035103.1|WP_109269186.1|515866_516436_+|acetyltransferase
MELTDLLEALDAGRTITGDSPLHEVMHRVSQEALRITGELNGGYREPARVRELLAQLTGRPVDASVTVFPPFRSDFGKNITLGKRVFINSGCTFQDQGGVVIGDDCLIGHNTVLATLNHDLAPSRRADMHPAPIVIGHKVWIGSNATVLPGVTIGDDAVVAAASVVTKDVPERSVVVGSPARVVRSVSD
>NZ_CP035103.1|WP_109269195.1|526443_527619_-|SpoIIE-family-protein-phosphatase
MQTHTAHTEVARVDALHALKILDTPREERYDRVVRLAQDVFGVKAAAVNLIDADRQFTKAEAGLDGLVHATRTDSLCARTVDRDAPLIVADAMTEQRFAGSSFVTGDDPVRFYAGHPLHAPGGEPVGSLCLVDSVPRELDERERRILAEMAGWVERELAAQMELDRAEQIQQMLMPRTGLVTPAVEAAGRCLPARSVGGDFYDWMVLGDEVQAMVTDVMGKGIPAALLSASARAVLRGTFQYNPPAEAMKRAAGALTPLLEEAGAFITAFIARVHTGTGEMSYIDAGHGLALILSPDGAHRRLISSGPPLGVVAEWIWDVHTTTLLPGQTLLVVSDGYLDFFDDLEAAVATAAALNTLAGTAEELVMLCSDYAGTSGADDDTTVLALRRTA
>NZ_CP035103.1|WP_109269196.1|527695_528715_+|arsenic-resistance-protein
MNAPTVAARAERHQVAVYLVAIAAAVLVGWTVPGAPALAPAITPVLGLLLFATFLAVPFAALGRAFADLRFLAALLVVNFVVVPVVVLGLSRPVAGHEALLLGVLLVLLAPCVDYVIVFTGLAGGAADRLLAAAPLLMLAQMLLLPAYLLLLAGPEAVALVELGPFAEAFVLLILLPLAAAAAVQRAASGSAAARRLESATGAAMVPLMALTLFTVIASQVRGVGEQLADLAAVVPLYAGFLVLMVPIGILAARLARLDVPVSRALVFGGVTRNSLVVLPLALALPERLALTPFVVVTQTLVELVGMVVLVRLVPALVRDRDPRHSGGTTPSHRKAPRP
>NZ_CP035103.1|WP_109269197.1|528711_529302_+|hypothetical-protein
MTQRLRPATQALRLWGPRQWGVAVLAGLATAVVLGLATVLIPNGLFSREIPPVWWNYPVWIATSALTGVLVASYVSPVAGGTPLPGDDDVAAATVARAVESGERRSARLGAVGTFAAWFAMGCPVCNKLALLALGSTGALTWFAPVQPWLGVLALALSAFAVVHRLAGQMACPVNLPVSTARNAVVPAAAEAPKGR
>NZ_CP035103.1|WP_109244245.1|529463_529949_+|pyridoxamine-5'-phosphate-oxidase-family-protein
MTDQDNGTAKVRQLIKDTRIAMLTHADEHGNLISKPMATQDVDFDGTVYFIAERTSDQVQDLQQRPAVNVAYAGDGAWVSLTGTALVLNDEAKLKELWDSFTGSWLEGGPENPNNILIEVTGRSAEYWDTPGGGKVTQVANLVKSKVTGHTIKGDKGVVDL
>NZ_CP035103.1|WP_017834030.1|530032_530215_+|PspC-domain-containing-protein
MNTSLVRPRNGKLIAGVCAALAARFGLPKFLLRLGFIVFGLVGVGELVYIALWIIIPKEA
>NZ_CP035103.1|WP_109244246.1|530218_530671_-|MarR-family-transcriptional-regulator
MTGQLSIGVLMFIAHRSAENRIVEAVRRAGYTDLTVPQARILARIGPDGTRLSELAEQAQVAKQTATVLVDRLERAGYVERTVDPRDARARLVRIAGRGIELVPIARAEEARIEAEWSAHLGERRMRQLREALTALREITDPHAGPEEQG
>NZ_CP035103.1|WP_035925626.1|530809_531457_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MGDDDVWAVIDLQRRRTADLLAGLSGEQWDHPSLCEGWTVRDVAAHLTLQQLGLGAALLSALRHPGGLNHVILESARDRARRPADRLVAGIRATVGSRRHNVGVTSLETLTDILVHGQDIAVPLGLELEMPPEAAAVAAERVRSTGGTRTARVFRHLPLEGFRFVATDVSWAAGEGPEIRGPAAALLLLLTGRRAGLDRLAGDGVEMLRHRLAPA
>NZ_CP035103.1|WP_035925293.1|531505_532531_-|LacI-family-transcriptional-regulator
MTPARPAVSIKEVAREAGVSIGTVSNVLNRPEVVSEDRRRRVLRVIEDLGYVRNDVARQLKAGRSRTVGLVVQDSANPFYNEIALGAETAAERLGQAVIIGNAGLSPERESLYLDLFEEQRVRGVLVTPQTPERARVDVLRSRGTPVVLVDEHAAPSEYCSLAVDDVEGGRAAVAHLLGTSRRRIAYVGGPDSLHQVRDRRAGAQRAVEAVPGASLESFSTTALTVLEGRRVGEQILELPPERRPEAVFAANDLLALGLLQAFAFTHRVRVPEDIALIGYDDIDFATSAIVPLSSIRQPARLIGRTAVELLEDEITDPGHHHRHVSFQPELVVRDSTRPAA
>NZ_CP035103.1|WP_017834026.1|532708_534007_-|MFS-transporter
MTTTKLGGWKATIAVSMSNYIEAGSIIALATSLSLWQEYFGFTNLAVGLVAALSANAFGAALGALIGGPLGDRYGRKFIYTYDLILYMIGTAFVIFAVAPWMLVLGVVLTGIAVGAGVPVAWTYIAEEAPSEARAKHVGTAQFAWSLAPALVFLFATFVVPLGLLGTRIVFAHLFVVAFVTWWVRRGLSESHTWKKSDEERRASEATGIKRRNYRELLTNRTNLKALLFLVGVYALWNLVAGQMGIFMPRVYETAGVESATQQNLLQVLLWSFTVLATWFGFMRYGDRVDRRLLYGIGALLGIAAWVLLVFAHVTMPVLILFAVLWGVSAGIGAQAFYALWAAEMFATRYRASAQGVLFFVARIVVGLLSYWFPTLLAEHGVPFVGMIMIGALLVALLVGVIGAPDTRGKSLEQIEEDRYGTPASRPAQPVG
>NZ_CP035103.1|WP_035925296.1|534072_534441_-|L-rhamnose-mutarotase
MGAHPSAATLQELIELPEEITRTRRCFLLHVRPEKLAEYVEVHQQVWPTMLAALRETGWRNYSLFLHPEDGLVVGCFEADDVASAQTLMDDHPVNARWQAEMAQYFVEGSHPEPLLPYFHLA

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Crispr_ID: NZ_CP035103_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP035103_2

1440200-1440268

Orphan

Consensus_repeat	Method
GCCGCCGCCGAAGCCTCCGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP035103_2

>merge|NZ_CP035103|2|1440200-1440268|CRISPRCasFinder
GCTGCCGCCGATGCCGCCGCCGAAGCCTCCGCCGCCACCGCCGAACCCGCCGCCGAAGCTGCCGCCGAA

>NZ_CP035103|2|2|1440200-1440268|CRISPRCasFinder
GCTGCCGCCGATGCCGCCGCCGAA	GCCTCCGCCGCCACCGCCGAA
CCCGCCGCCGAAGCTGCCGCCGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP035103.1\|WP_017833618.1\|1444034_1444502_-\|tRNA-(cytidine(34)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|223297
NZ_CP035103.1\|WP_051063784.1\|1447615_1448590_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239426
NZ_CP035103.1\|WP_017833625.1\|1451205_1452900_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237448
NZ_CP035103.1\|WP_109268072.1\|1433137_1434610_-\|zinc-dependent-metalloprotease	unknown	unknown	gnl\|CDD\|378392
NZ_CP035103.1\|WP_017833621.1\|1447139_1447541_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|181719
NZ_CP035103.1\|WP_109268075.1\|1423944_1427433_+\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP035103.1\|WP_081615776.1\|1444500_1445766_+\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP035103.1\|WP_109243520.1\|1429814_1431617_+\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223288
NZ_CP035103.1\|WP_109222094.1\|1434826_1435906_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|226011
NZ_CP035103.1\|WP_109268250.1\|1428696_1429791_+\|NAD(+)-diphosphatase	unknown	unknown	gnl\|CDD\|234699
NZ_CP035103.1\|WP_035927587.1\|1432592_1433162_+\|M48-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320703
NZ_CP035103.1\|WP_081615777.1\|1445926_1447129_+\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP035103.1\|WP_017833616.1\|1439295_1440039_-\|PspA/IM30-family-protein	unknown	unknown	gnl\|CDD\|224755
NZ_CP035103.1\|WP_109268071.1\|1436063_1439051_+\|UPF0182-family-protein	unknown	unknown	gnl\|CDD\|377101
NZ_CP035103.1\|WP_167508864.1\|1431607_1432429_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238768
NZ_CP035103.1\|WP_109268070.1\|1452995_1453790_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_CP035103.1\|WP_109243516.1\|1449538_1451209_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP035103.1\|WP_109243507.1\|1442524_1444000_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|273938
NZ_CP035103.1\|WP_167508863.1\|1427408_1428602_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|270701
NZ_CP035103.1\|WP_017833623.1\|1448774_1449458_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
NZ_CP035103.1\|WP_017833618.1\|1444034_1444502_-\|tRNA-(cytidine(34)-2'-O)-methyltransferase	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	4.51732e-74
NZ_CP035103.1\|WP_051063784.1\|1447615_1448590_+\|hypothetical-protein	gnl\|CDD\|239426	cd03310, CIMS_like, CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to L-homocysteine without using an intermediate methyl carrier. The active enzyme has a dual (beta-alpha)8-barrel structure, and this model covers both the N-and C-terminal barrel, and some single-barrel sequences, mostly from Archaea. It is assumed that the homologous N-terminal barrel has evolved from the C-terminus via gene duplication and has subsequently lost binding sites, and it seems as if the two barrels forming the active enzyme may sometimes reside on different polypeptides. The C-terminal domain incorporates the Zinc ion, which binds and activates homocysteine. Side chains from both barrels contribute to the binding of the folate substrate.	1.02408e-16
NZ_CP035103.1\|WP_017833625.1\|1451205_1452900_+\|hypothetical-protein	gnl\|CDD\|237448	PRK13614, PRK13614, lipoprotein LpqB; Provisional.	0
NZ_CP035103.1\|WP_109268072.1\|1433137_1434610_-\|zinc-dependent-metalloprotease	gnl\|CDD\|378392	pfam10103, Zincin_2, Zincin-like metallopeptidase. This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family has similarity to Peptidase_M1 (pfam01433, Structure 3CMN).	2.38985e-144
NZ_CP035103.1\|WP_017833621.1\|1447139_1447541_+\|chorismate-mutase	gnl\|CDD\|181719	PRK09239, PRK09239, chorismate mutase; Provisional.	4.33432e-46
NZ_CP035103.1\|WP_109268075.1\|1423944_1427433_+\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	8.66502e-95
NZ_CP035103.1\|WP_081615776.1\|1444500_1445766_+\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.41541e-152
NZ_CP035103.1\|WP_109243520.1\|1429814_1431617_+\|ATP-dependent-helicase	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	8.27775e-91
NZ_CP035103.1\|WP_109222094.1\|1434826_1435906_+\|PDZ-domain-containing-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	4.34745e-68
NZ_CP035103.1\|WP_109268250.1\|1428696_1429791_+\|NAD(+)-diphosphatase	gnl\|CDD\|234699	PRK00241, nudC, NAD(+) diphosphatase.	7.41772e-73
NZ_CP035103.1\|WP_035927587.1\|1432592_1433162_+\|M48-family-metallopeptidase	gnl\|CDD\|320703	cd07344, M48_yhfN_like, Peptidase M48 YhfN-like, a novel minigluzincin. M48 YhfN-like protease is considered as a CaaX prenyl protease 1 homolog, with most of the sequences in this family as yet uncharacterized. It contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is probably associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. This novel family of related proteins consist of the soluble minimal scaffold similar to the catalytic domains of the integral-membrane metallopeptidase M48 and M56, thus called minigluzincins.	2.76647e-20
NZ_CP035103.1\|WP_081615777.1\|1445926_1447129_+\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP035103.1\|WP_017833616.1\|1439295_1440039_-\|PspA/IM30-family-protein	gnl\|CDD\|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	3.03432e-22
NZ_CP035103.1\|WP_109268071.1\|1436063_1439051_+\|UPF0182-family-protein	gnl\|CDD\|377101	pfam03699, UPF0182, Uncharacterized protein family (UPF0182). This family contains uncharacterized integral membrane proteins.	0
NZ_CP035103.1\|WP_167508864.1\|1431607_1432429_-\|hypothetical-protein	gnl\|CDD\|238768	cd01491, Ube1_repeat1, Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating (E2), and/or ligating (E3) enzymes and then targets them for degradation by the 26S proteasome. E1 activates ubiquitin by C-terminal adenylation, and subsequently forms a highly reactive thioester bond between its catalytic cysteine and ubiquitin's C-terminus. E1 also associates with E2 and promotes ubiquitin transfer to the E2's catalytic cysteine. Ubiquitin-E1 is a single-chain protein with a weakly conserved two-fold repeat. This CD represents the first repeat of Ub-E1.	6.37247e-08
NZ_CP035103.1\|WP_109268070.1\|1452995_1453790_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	1.58478e-22
NZ_CP035103.1\|WP_109243516.1\|1449538_1451209_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.44183e-55
NZ_CP035103.1\|WP_109243507.1\|1442524_1444000_+\|PDZ-domain-containing-protein	gnl\|CDD\|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	2.6334e-82
NZ_CP035103.1\|WP_167508863.1\|1427408_1428602_-\|phosphotransferase	gnl\|CDD\|270701	cd05152, MPH2', Macrolide 2'-Phosphotransferase. MPH2' catalyzes the transfer of the gamma-phosphoryl group from ATP to the 2'-hydroxyl of macrolide antibiotics such as erythromycin, clarithromycin, and azithromycin, among others. Macrolides penetrate the bacterial cell and bind to ribosomes, where it interrupts protein elongation, leading ultimately to the demise of the bacterium. Phosphorylation of macrolides leads to their inactivation. Based on substrate specificity and amino acid sequence, MPH2' is divided into types I and II, encoded by mphA and mphB genes, respectively. MPH2'I inactivates 14-membered ring macrolides while MPH2'II inactivates both 14- and 16-membered ring macrolides. Enzymatic inactivation of macrolides has been reported as a mechanism for bacterial resistance in clinical samples. MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	4.6999e-72
NZ_CP035103.1\|WP_017833623.1\|1448774_1449458_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.99389e-86

>NZ_CP035103.1|WP_017833616.1|1439295_1440039_-|PspA/IM30-family-protein
MIKQSIFGRIAQLAKANINGMIDAAEDPQLMLDQMVRDYTENIREAEAAVAQTIGSLRLLEQDHAEDVRESQEWGNKALAASNKAEEYRGAGKSSEAEKFDNLAKVALQRQIQYETEARGAEPQIQSQTQVVEKLKDGLNKMRGKLQELSNKRDELNARQKTAQAQSQVQDALKAFDVLDPTSEVSRFEDKIRREEARVLGQQELAASSLDAQFESLESLGQQSEIEARLAALKSRNAERIVSSEEV
>NZ_CP035103.1|WP_109268071.1|1436063_1439051_+|UPF0182-family-protein
MTAGPTAPRPPRQQPAGQRRKRGALWPTVVVVLVLVAAFVGLTQLYTDVLWYDQLGYLSVFVTENVTKIVIFVVAAVLVAALMFASLFLAYRSRPITAESIVDDNLRRYQEALEPVRKIAIVVVPVLFGLFAASTAMTQWDTVLLFLNQEPFGQEDPQFGLDIGFYVFTLPFLRFLIGFLVSAILLAGVAGILMHYVYGGIRITERGLSTTRASRVHLGVLAALFLLLQAANFWLDRYSTLQSTSGTWTGALYTDVNAVIPTKAILAAAALIVAILFVVASFIGRWRLPIIGTAMLLVVAVVAGGIYPWIVQRFQVTPTEQALESQYIQRNIDLTRSAYGLDAAEVMPYDATTETEQGALRQDTETTSNIRLLDPNVVSAAFSQLQQFRPYYQFPDTLNVDRYEIDGEVQDTVIATRELNPDQNQGWFNQHVVYTHGYGVVAAYGNRVEVDGKPQFMQSGIPSRGVISDDYEPRIYFGENSPLYSIVGGAEGDEPLELDRPQTAGDEAGDAKTTFAGNGGPSIGNFFNRLAYGIKFQSSDMLLSDAVRPESQILYDRDPRERIEKVAPYLTVDGAPYPAIIDGQVQWIVDAYTTSDAFPYSTPSVLQEATQDTQTAQGAAAALPPERVNYIRNSVKATVNAYDGSVNLYAWDDQDPVLKAWQNVFPSTLKPYSEMSAELMAHVRYPQDMFKVQRELLNRYHVTDSGSFYQNDDVWSVPNDPTQDSDVALPPYYLSMRMPGEEEANFSLTTSFIPQQSETGNTRNVMYGYLSANSDAGTGEDGVKSDEYGTLRLLELPRSSVVPGPGQAQNLFNSDTDVSTELNLLRQGASEVINGNLLTLPAGGGMLYVQPVYVQSSGDAAYPTLRRVLVGFGEEVGFAPTLEEALDEVFQGDSGAQTSSGAGVDEAEAGSPDGAGEDGAEAPAGGASLEDALSDANQAIQESEEALQDGDWTSYGEAQQRLQDAIERALEADGVVAPEAEGALAPEEPAEQPAE
>NZ_CP035103.1|WP_109222094.1|1434826_1435906_+|PDZ-domain-containing-protein
MTASPRPRRALRRRGLESWALLGSAGLLLAGAVLPAPFVIEAPGPTFNTVGEHDGRQLLGVSGAPTYPSDSVLDLTTVYVTGGPNKNVNVLTVLGSWLDPSASVVPADTLYPRDVSGEEADQYSMAAMSSSQEDSVAAALTHLGQDFSTRLSVQDTVPGGPAEGVLEHGDVLRGVDGEPVSSLPSLKSALDAAGERGVTLQVERAGSPRDVEVDTVRDEASGNWQLGVFLLAAYDFPIDVAFELDEVGGPSAGLMFALGIVDEMTPGSIAGDRHVAGTGTITPEGEVGPIGGIRQKLEGAAAAGAEVFLAPADNCAEAQGHVPEGLTVVSVRTLDDAVAAAEAAGSGGDLSALPGCAAR
>NZ_CP035103.1|WP_109268072.1|1433137_1434610_-|zinc-dependent-metalloprotease
MTPQPPNDRPGNTPGDDSGDGPKDPFQEMLERLMGQSGMSPEDLQRAGVPVDPQAMSMMFQQIQSMMGAGASEGPVNWKLAHDHARQIAAADGDPSVTPAQRGAVEDAMRLAELWLADHTEFGQTSIRPQAWSRAEWIEATQETWKDMTGPVAESVTKALTDALTQQLPPELSAMMGGASGMLAGAGGMLFGIQLGQAIGGLSREVLCSTDIGLPLAEGRSGLLPASIRAFGEGLDIPAQEIMLYVAVREAAHVRLFAANPWLRQHILDLVKRFSAGIHIDMSRIEEAARDIDPMDPSSMQEALSSGIFAPQQTPDQEVTLKRLETVLALVEGWVHVVTVASTANLPSGEALSETVRRRRAAGGPAEHAFGSLVGLELRPRRLREAAQFWEYVGERRGVEDRDGLWDAAELLPTDEDLDDPAGFTERRGLLTASEDEVDAALQRLLSGGYEGPDGGPGADGGPATDPAPGADGGPGRPEDDGPQDGDGSR
>NZ_CP035103.1|WP_035927587.1|1432592_1433162_+|M48-family-metallopeptidase
MPVPSQPEVVVRRSARRRKTVSAHWSEDTVVLSVPQTATRREIEHWTRELVPRVVERRRREAAKGADRRSDDHLLQRAHELSRRHLDGRARPSDVRWSGRQHTRWGSATPATGVIRISAQLQQAPEWVLDFVLVHELAHLLEADHSPRFRELEARYPLAEKARAFLDGAAWAHRHAGRAGADQREPSPS
>NZ_CP035103.1|WP_167508864.1|1431607_1432429_-|hypothetical-protein
MPTTPFPGPPQGSPHDPELRLSCLERPRPDEVHVLLLGLDGLAAALAVRLLRCGVLGLNVSDTAPVAAADLGTGAYRPADVGRSREAALRRRLRELDPRCAPVSAPELFPGALLPGTVVVHSSGRPAPDGRLPPGAVEPEAWAGIDPRHPVVSLHHADGVLLRWPTVPWAHRPCPDCVRATLEHTQPRTAPHGPAAVLAAWAGAAHAEAVAVRLAVEVLAVALDSLCGAGAEGHGHREQGGAGRAAFYAPPWPDAVSWPEPDRSRCLCGLDQA
>NZ_CP035103.1|WP_109243520.1|1429814_1431617_+|ATP-dependent-helicase
MESTLEERILAGLDPEQREVATTLRGPVCVLAGAGTGKTRAITHRIAYGIATGVYTPQKVLALTFTARAANEMRNRLRELGAAGVQTRTFHAAALRQLQYFWPQAVGGPLPGLVEHKARLITEAAQNMRLSTDRAAVRDLAAEIEWAKVSMLTPDTYPTRAAGREMPLNYDVRTVQRLYQSYEELKTDRHLIDFEDVLLLTVAVLEEDERVAATVREQYRHFVVDEYQDVSPLQQRLLDAWLGGRDDVCVVGDASQTIYSFTGATSRHLLEFPARHPQARVIELVRDYRSTPQVVETANRLLAARRPARGSTPGAWATPLRLVAQRPDGPPPSWNEYADDEAEAAGTAARIRDLVDDGVPASEIAVLFRTNGQSQAFETALAEAGIGFQLRGTERFFNRPEVKQAVVQLRTAARAAEASDEPTRLVRDILSSLGYSDRAPRSTGAVRERWESLAALVSLADRMAAEAAAREEQFVLPDFAAELERRMAQQDAPVMNGVTLASLHSAKGLEWDAVFLAGLSEGLMPIGFAETADEIDEERRLLYVGITRAREHLVLSWTLSRTPGGRPTRKPSRFLDALRETGGDRPAPRRSRPGGARAHA
>NZ_CP035103.1|WP_109268250.1|1428696_1429791_+|NAD(+)-diphosphatase
MGDVPASTPSEPVSGSRPVPAPERLSPARLPFAATAFDRDAVDRELHDVRVLAAQDPTTLVLVLAGGLAPVAGDALVLVPAAELPAVPHDPRRPEVYLGRLPGADGAPGPRVLLRAVAAPEPGREDAAAEPFAVPEPLVAAVTAFASGRRGEELRWAGLRELGPVLPTRDTSLLVTAQSVGLWHRDHPRCPQCGEPTEVIRSGWARRCPNDESLHFPRTDPAIIVAVSDGDPDPDRERLLLGRSALWKGNRFSTLAGFVEPGESLEQAVVREVAEEAGLTVGDVQYLGSQPWPFPRSLMLGCRAVVRSGAAVPDGQEILELRWFTRAQLREAARTGSVTLPGRVSIAHALIAHWLGEDLPETAW
>NZ_CP035103.1|WP_167508863.1|1427408_1428602_-|phosphotransferase
MSTSLEHLAAVAAAGVPGLAPVAVGPSPDDDADFRSAVVLDASGRRWRVRSPLSPEASVRLETEHLVLRSFTPAVRSRLPFLVPTAAGSVAHGDLHAFVHSHIEGAPLDIDALARMAAEPDPEHHRHVPSAEPPPTLTVQLGRLLAAIHALPTALVLDADLPGYTAEQCRQRRRTELHRAADTRRVPAALLHRWEQVLEDRAVWRFQPRVVHGDLQEDDLVISRGRVRGVTGWTDLHVGDPAEDFAWLFAARDARLAEGVLEAYAAACRRTSFQAPDGAPDPHLLDRARLEAELALAQWLVRGVDRGAQDLVADAEQMLATLEQDVARRPEPVAAAPETAPAAPGQDDASQDAAPDRAPGDTAAEDPAPAGGPEAPSGRTPPTGPGGGPAQGRSTTS
>NZ_CP035103.1|WP_109268075.1|1423944_1427433_+|ATP-dependent-helicase
MTDAPDDRTRLDAAEHPYGGVEPRYSPEELAELLGGNLPTAQQSAVISAPLTPRLVVAGAGSGKTATMVDRVVWLVANGVVAPDQVLGVTFTRKAAGELGERMRSRLARLRAQGLVAPAHTEEDDLPAAPQDPTVSTYHSYANTLVRNYGLRIGIEPDTTLLGQARTWQLAAQTVEAWTGELLETMPAKSTMVAAVLDLASACAEHLVDPADVERFAAELLGALATTPPGRRKKTLGAQLKKVEDNQRTAWVLAELVADFARRKREAQAMDFGDLLSAAARLAEQDPAARRTERERHRVVLLDEFQDTSHAQLRLFAALFGQGHSVMAVGDPQQSIYGFRGASSGQLFGFYDSFPVAPGQDGEPSFLTTAWRNDASILDVANTIAAPLRTLPAWARSTSSLAVPELTPRPGAGTGRVRISRYATDVEEAVALAERVRERREQHRGDPEEQMPTMAVLCRKRSQIEPVRRELAARGIPYEVVGLGGLLSTPEVSDVVATLRVLDDPGRSDALVRLLAGARWRIGTRDLMALADWASHLERRRTEAAQAGRAEDLESPVTAEEAQEDALVEPDLSDHASLIEALETLPWPGWMSAHARTLSETARERLIRLRTELDHLRSFLSDDLPSLLHEVETVLGLDVEVAAHPHRPVHQARRNLDAFHEAAQSFTAFSASSDVSAFLAWLDVTLAEENGLEPGPDRTRHDAVQLVTVHASKGLEWDHVYVPGLNAGNFPTDRPSRWTLDTGTLAWPLRGDARFLPQWAVDTSDLKALEESHTEFLELAAQHAEDEERRLAYVAVTRAREVLELSCTVFRGTAAKGQEPSVFVAELAPLTEGPEPSVRPGPWAEVPEGARNPAAATVLSAPWPYDPLEGPEVTETVTDEYGHSAVRVSPPPYRGRRAVLERAARAVRERGFEDTADLDVEDLLGVAERDGLAPDPRRWSEEAKILLARHEDGRAERTVPMPSHVSASTLVALARDPLEVVSGLRRPMPRRPGTAARRGTTFHAWIEQYYGSSAIFDVGELPGTADDYVDAAYDLPELAATFRSSPWADRQPYAVEFPLETPIAGVTVRGRVDAVFRNGDGTWELLDWKTGRAPSGRELQERSAQLAVYRLAWSRLRAVPLEEVTAAFYYVAEDRVVRPHDLSGAEELEAVVREAYDVVLRP
>NZ_CP035103.1|WP_109243507.1|1442524_1444000_+|PDZ-domain-containing-protein
MSEPRDPRYGADPQLTQPLPPVYGRPAHDPWASGAEQDARAGHGAPQAGGQDAGPYAGAWQGAGDPAARHPWGNGTGSGTGGRRERRRFSGGSLVTGMVLAALVGAGAAVGTDALLDGGGAAPAAGGSTSSSVIVNDQDEVNAVTAAAVKASPSVVTISASGGGQNGSGSGVIIDDEGHILTNTHVVTLDGTTSSPSLEVQLDDGRVLPAEVVGTDPLSDLAVLKVDAQGLTPATLGSLDDVNVGDTAIAIGAPLGLAGTVTDGIVSTLNRTITVASSAAPSTPSEGDGEGEEQGGGNDFFFNFPDEDGGSGGRSQGSSPSVFLNVIQTDAAINPGNSGGPLIDTDGEVIGINVAIASAGSGTEAGNIGVGFSIPVDTAQRVAVEIINNGRATHGYLGTSVSAAPGADGRSRAFSDGAAVEQVVPGSPADEAGLEVGDVITEFDGHRIQDASSLTAAVRELPAGGTGTMTFVRDGEERTADVTVGDAEEQQ
>NZ_CP035103.1|WP_017833618.1|1444034_1444502_-|tRNA-(cytidine(34)-2'-O)-methyltransferase
MLRILFHTPEIPGNTGNAIRLAAVTGAELHLVEPLGFDFGSAHLRRAGLDYHDLAVLTVHPDLDAAWAALAPERVWAFTTDGEVSHTDVAYRPGDVLLFGPESVGLPAAVKADPHVTARVRIPMLPARRSLNLANSASIAVYEAWRQLGFAGAGS
>NZ_CP035103.1|WP_081615776.1|1444500_1445766_+|cysteine-desulfurase
MTASLRTPDARPGRGPRLESVPHEPAYLDHAATAPLRPSALAAVAEQLARGGNPSSLHRPGRAARAVVEQAREDVAAALGAEPVEVVFTSGGTEADNLAVQGLYRHRREQDPRRRRVLVSAVEHAAVSDTVEWLAAHEGAEAVWLPVDAAGRVDPAAVREELARDPGATALLAVMWANNEVGTVQPVAEIAALAEEFGVPFHCDAVQAFGALPVDAHLPGLTTLAVSAHKVGGPVGAGALVAGRTVGLAPVQHGGGQERTVRSGTLDAAALAGFGVAAREAAAERETEQERLAGLRDRLVEGVRRIVPDAVLRGPEDREHTGARLPGNAHFTFPGCEGDSLLFLLDGAGIASSTGSACHAGVPRASSVLLAMGLDEATARGAQRFSLGRTSTGADVDALLAALPEVHRRALRAGLSGAAPV
>NZ_CP035103.1|WP_081615777.1|1445926_1447129_+|tRNA-2-thiouridine(34)-synthase-MnmA
MRVLAAMSGGVDSAVAAARAVDAGHDVTGVHLALSRTPGTLRTGSRGCCTIEDSRDAWRAADVLGIPYYVWDFSERFQADVVDDFVAEYAAGRTPNPCLRCNEKIKFAALLEKALALGFDAVCTGHYAKVVEDPAGGRELHRAADWAKDQSYVLGVLTAEQLEHVLLPLADTPSKAEVRAEAARRGLSVASKPDSHDICFIPDGDTRGWLAERIEMTEGEIKDVEGNVVGTHSGANAFTVGQRKGLRIGTPAPDGKPRFVLEIRPRTNEVVVGPQAMLAVDELRGIRPSWAGAPVPEAAPLLRPGAAAGAASAPFPVLAQVRAHGDPVPARAHLELVEGDGGPLPELVVRLEEPMRGVAPGQSVVLYQGTRVLGQATVDRAHSLARPDVPGGAGRPDPAR
>NZ_CP035103.1|WP_017833621.1|1447139_1447541_+|chorismate-mutase
MTAPHPHASADVRAHQDFDATASSLQEQADPRVLAELQSIRGTIDNIDAALVHLLAERFKATQRVGVLKATHGLPAGDPDREAAQIGRLRALAASAQLDPEFAEKFLNFIISEVIRHHVALSEDHRRQDDDRP
>NZ_CP035103.1|WP_051063784.1|1447615_1448590_+|hypothetical-protein
MPGTDVVESVTLLRGELGAPHISFLPVLPARGAAADPVARTAAVLDDLYADRQPHGLRVSGVPGKDSRSARALLAGDVNVLADVIGAESGPDDAPVKTQLVGPLSLAARLHLHAGERALKDHGARRDIADSLASGVLEHVRAVRAAAPGRDVLVQLDEPELARVLAGGLPTMSGYRTLRAVPAAEARRSLTAVVEACRSAGAAGVTLRLPPGVDPRLARETGADAVQVPAPAGTVHDWEPLAALVEDGMQLWLGLVPAAGGTARALAADVWSVWRDLGLPAAALDRVRITPREELDALGPAELREVLARVTGTASALARTAADA
>NZ_CP035103.1|WP_017833623.1|1448774_1449458_+|response-regulator-transcription-factor
MNARILVVDDDAALSEMIGIVLTAEGFEPVFCYDGATAVDTFRAVRPDLLLLDLMLPGKDGIQVCREIRTISDVPVVMLTAKSDTVDVVRGLEAGADDYVPKPFKPAELVARVKARLRPVERANSQELRIGDLTIDVSGHSVHRGDHEIGLTPLEFDLLTALARAPHQVFSREMLLRDVWGYQHAADTRLVNVHVQRLRSKIERDPESPEIVVTVRGVGYKAGTSAR
>NZ_CP035103.1|WP_109243516.1|1449538_1451209_+|HAMP-domain-containing-histidine-kinase
MLARRWRQSLQFRAIAVSLSLTALAFFVTGSFLSHQIADRLFSERLDQVLASATADFEQVQASFDASDASDRDELQALVASTLGSLSVDGAETERWILLPMDFTSGQTLIPAQSQSPWMTSSTVPPELQERLAEQDGVFWQPASVRVTENGEEAPVIVVGTVVDLYQNSRYGLYLVYDFSEPQRTLDAMHAVLLLSVVVLLLLVGAIVWYVTREVVRPVSSTARVAEQLADGDLGVRMPVSGSHEVARLARSFNRMADSLQDQITQLEQLSSMQQTFVSDVSHELRTPLTTVRMAAEVLFNAREDFDPVNRRSAELLYHQVDRFDALLADLLEISRFDAGAARLEVASVELFSVVHDVVEAAAPLAVSSGSTVRVRSELSRCTVQGDQRRIERILRNLVVNALEHGEGRPIDIVVGASEVAAAVAVRDHGIGMTEEEAAKAFNRFWRADPARARTTGGTGLGLAIATEDTRLHGGRLDVWGAPGEGACFRLTLPRTRGRRLVPDDESPLGLPPDADAYPETAVVTRTGTLALASAAAAEPAPPAAAQPTDVEEDRS
>NZ_CP035103.1|WP_017833625.1|1451205_1452900_+|hypothetical-protein
MSRTRRQTRTAALALAAAVALGGCGAIPRTGPVHRHAEPTRSAVQPSYDVEPAGPREGATPEQIVRGFLAAGTGVADDYSVAREYLTPELAGTWHPDARTLVHRGDAVPVPRLEDNEYRVNLEVDSVVDGSGVIERKPAGATEVLDFDVVQVDGQWRISDAPDATALTPADFEDIFEPHHLYFADEDLSNVVVDPRWFPDRVPVSTSIVRALLGGPAPYLRGAVTSAFPPGTTLARSAVPVRDGTATVELSVPEFDPANIEINRRMHDQLALSLRSLTAVNDVELLVEGAPVELGAGWTDAAPVQDVTVPSRQVGLREGDLVFYQGGQTENVDGIPPLDGHHPSSPAMDAAAEHFAFVDTGTGSLVTVAREEEPVEQFSGTGLTRPSFDEHGWVWTGDSAGTVRAVRAVPGAGSPVRVEASWLAARTVTSLRVSRGGTRALVVTEDEGVSQIWLTGVVREPDGTPRRLNEPFRVAADVDADAALWLSDREFVAAPLGGTGSVRPRVYDVSGRFRELPGIEGLTGLSGGNGTSSVYAVAGGTLHMLTGNAWAPQSEDVLDTAFAG
>NZ_CP035103.1|WP_109268070.1|1452995_1453790_+|ComF-family-protein
MPATPPTARALDRAAARALDRLTEAAEVLLPVECAVCRAPGTALCRACRLVLRRSCARPFEASSAAPLLDPPLSVVAAGRYAHGLATCLLALKSTGRTDLVPVLAACLATALHAAAPGWPAGPVLLVPVPTSPAALRRRWFDPVRLLLEDCARRGALPAGTLVSRGLRHRAAGASLTGPAQKRLGTAGRRARPAGSMRAAAAPGARCVVVDDVLTTGATLGEAARALRAGGAEVLGAVVLAAVRPPAVPLTADSGPARPGEYPV

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Crispr_ID: NZ_CP035103_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP035103_3

1499037-1499131

Orphan

Consensus_repeat	Method
CCTGGTGCTGGGCATCGTGGCGCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP035103_3

>merge|NZ_CP035103|3|1499037-1499131|CRISPRCasFinder
CACGGGGCTGGGCATCGCCTCCCTGGTGCTGGGCATCGTGGCGCTGCTGACGTGCTGGTTCGTGCTCGGCCTCGTCCCGGGCCTCGTGGGCCTGG

>NZ_CP035103|3|3|1499037-1499131|CRISPRCasFinder
CACGGGGCTGGGCATCGCCTCCCTGG	TGCTGGGCATCGTGGCGCTGCTGACGTGCTGGTTCGTGCTCGG
CCTCGTCCCGGGCCTCGTGGGCCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP035103.1\|WP_017833663.1\|1500317_1501427_-\|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl\|CDD\|206747
NZ_CP035103.1\|WP_095650608.1\|1505661_1509504_-\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	unknown	unknown	gnl\|CDD\|237030
NZ_CP035103.1\|WP_109268042.1\|1493596_1494757_-\|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|223525
NZ_CP035103.1\|WP_109268041.1\|1496044_1497280_-\|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl\|CDD\|377253
NZ_CP035103.1\|WP_109268044.1\|1491334_1492189_+\|LamG-domain-containing-protein	unknown	unknown	gnl\|CDD\|379155
NZ_CP035103.1\|WP_017833665.1\|1502816_1503356_-\|DoxX-family-membrane-protein	unknown	unknown	unknown
NZ_CP035103.1\|WP_017833651.1\|1489247_1489472_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP035103.1\|WP_017833670.1\|1509775_1511233_+\|GuaB1-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|181127
NZ_CP035103.1\|WP_017833660.1\|1497458_1497935_+\|SsrA-binding-protein-SmpB	unknown	unknown	gnl\|CDD\|376590
NZ_CP035103.1\|WP_017833662.1\|1499447_1500245_-\|histidinol-phosphatase	unknown	unknown	gnl\|CDD\|273949
NZ_CP035103.1\|WP_109268248.1\|1501416_1502796_-\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NZ_CP035103.1\|WP_031283102.1\|1504928_1505528_-\|lysophospholipase	unknown	unknown	gnl\|CDD\|238873
NZ_CP035103.1\|WP_017833666.1\|1503665_1504334_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|131992
NZ_CP035103.1\|WP_109268040.1\|1511427_1512789_+\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP035103.1\|WP_138976459.1\|1492371_1493517_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|181843
NZ_CP035103.1\|WP_017833652.1\|1489474_1489882_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377921
NZ_CP035103.1\|WP_017833658.1\|1494845_1495967_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_CP035103.1\|WP_017833667.1\|1504336_1504603_+\|mycothiol-system-anti-sigma-R-factor	unknown	unknown	gnl\|CDD\|274904
NZ_CP035103.1\|WP_109222182.1\|1490066_1490435_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP035103.1\|WP_017833654.1\|1490431_1490941_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379164

Protein	Function_ID	Function_description	E-value
NZ_CP035103.1\|WP_017833667.1\|1504336_1504603_+\|mycothiol-system-anti-sigma-R-factor	gnl\|CDD\|274904	TIGR03988, antisig_RsrA, mycothiol system anti-sigma-R factor. Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors].	4.42705e-16
NZ_CP035103.1\|WP_095650608.1\|1505661_1509504_-\|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0
NZ_CP035103.1\|WP_017833663.1\|1500317_1501427_-\|ribosome-small-subunit-dependent-GTPase-A	gnl\|CDD\|206747	cd01854, YjeQ_EngC, Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases. YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain.	1.08129e-77
NZ_CP035103.1\|WP_109268041.1\|1496044_1497280_-\|polysaccharide-pyruvyl-transferase-family-protein	gnl\|CDD\|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	1.92623e-11
NZ_CP035103.1\|WP_109268044.1\|1491334_1492189_+\|LamG-domain-containing-protein	gnl\|CDD\|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	4.5683e-10
NZ_CP035103.1\|WP_017833652.1\|1489474_1489882_+\|hypothetical-protein	gnl\|CDD\|377921	pfam07811, TadE, TadE-like protein. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in question is this family has a high proportion of hydrophobic amino acid residues.	8.81898e-07
NZ_CP035103.1\|WP_138976459.1\|1492371_1493517_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|181843	PRK09423, gldA, glycerol dehydrogenase; Provisional.	0
NZ_CP035103.1\|WP_017833670.1\|1509775_1511233_+\|GuaB1-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|181127	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein.	0
NZ_CP035103.1\|WP_017833660.1\|1497458_1497935_+\|SsrA-binding-protein-SmpB	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	1.47277e-86
NZ_CP035103.1\|WP_017833662.1\|1499447_1500245_-\|histidinol-phosphatase	gnl\|CDD\|273949	TIGR02067, his_9_HisN, histidinol-phosphatase, inositol monophosphatase family. This subfamily belongs to the inositol monophosphatase family (pfam00459). The members of this family consist of no more than one per species and are found only in species in which histidine is synthesized de novo but no histidinol phosphatase can be found in either of the two described families (TIGR01261, TIGR01856). In at least one species, the member of this family is found near known histidine biosynthesis genes. The role as histidinol-phosphatase wsa first proven in Corynebacterium glutamicum. [Amino acid biosynthesis, Histidine family].	5.62256e-97
NZ_CP035103.1\|WP_109268248.1\|1501416_1502796_-\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	6.68384e-155
NZ_CP035103.1\|WP_031283102.1\|1504928_1505528_-\|lysophospholipase	gnl\|CDD\|238873	cd01835, SGNH_hydrolase_like_3, SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	2.33331e-63
NZ_CP035103.1\|WP_017833666.1\|1503665_1504334_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|131992	TIGR02947, putative_RNA_polymerase_sigma_factor, RNA polymerase sigma-70 factor, TIGR02947 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and (with the exception of a paralog in Thermobifida fusca YX) one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria and each gene examined is followed by an anti-sigma factor in an apparent operon.	4.06711e-112
NZ_CP035103.1\|WP_109268042.1\|1493596_1494757_-\|glucose-1-phosphate-adenylyltransferase	gnl\|CDD\|223525	COG0448, GlgC, ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism].	5.18756e-134
NZ_CP035103.1\|WP_017833658.1\|1494845_1495967_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
NZ_CP035103.1\|WP_109268040.1\|1511427_1512789_+\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	4.69858e-112
NZ_CP035103.1\|WP_017833654.1\|1490431_1490941_+\|hypothetical-protein	gnl\|CDD\|379164	pfam13400, Tad, Putative Flp pilus-assembly TadE/G-like. This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG.	0.00333658

>NZ_CP035103.1|WP_017833660.1|1497458_1497935_+|SsrA-binding-protein-SmpB
MAKKDTGRQVVANNKKARHDYHILDTYEAGLALMGTEVKSLRMGRASLVDGFCQFTDGELWLEGVHIPEYLQGSWTNHSARRRRKLLLHRSEMDKIQQKTRESGFTIVPLSLYFVDGKKAKVEIAVAKGKREYDKRQTLREQQDNREAQRAMRYKNLG
>NZ_CP035103.1|WP_109268041.1|1496044_1497280_-|polysaccharide-pyruvyl-transferase-family-protein
MLEPVPIERPPAADVLYLVGTSGHPNFGDEFIAASWLRFLARARPGAEVWLDCPHPGLASHLFDGLHPGLRTTDTLWRLAFETTGMDPAAADAHVDRVVTHLGSPRYDLGLLGARRASSVHFLGGGYLNSIWPHHARLLRAALRLREVSGARLAATGLGLAPATDAEGLRAALGAFDHATVRDAPSAQLARADRAPDDAFLGLPGLAGFTGAPAEGTDDGDVWVCLQSDMTEPGILDGAVAAVRAALTGPALAGRTVRYLEAIPGADRAAFDRLADLVPEENFVPFTRLWQEGFPARPGQTWITSRFHFHLLAAACGAEGTALEVNPDYYRVKHQSLLEAGTGWSVTPTGGTEPSAPARSHAFPATAARLHRTKLREAEELYPAAAAPEDDPAGTEPRTRPGRTVARFLRR
>NZ_CP035103.1|WP_017833658.1|1494845_1495967_+|peptide-chain-release-factor-2
MASLDFPAEISALRSTFASIEAVSDVDAIKRDIAELSQQATAPDLWDDQAAAQKITSKLSHKQSDLERLEKLGGRIDDIEVMVQLAAEEDDAETLELAVEELAAVKKALSRLEVQTLLSGEYDEREAVVTIRSGAGGVDAADFAEMLMRMYLRWAERHGYPTTVLDTSYAEEAGLKSATFEVKAPYAFGTLSVEAGTHRLVRISPFDNQGRRQTSFAAVEVIPLIEQDDSIEIPESEIKVDVFRSSGPGGQSVNTTDSAVRMTHIPTGIVVSMQNEKSQIQNRAAALRVLQSRLLLQRQEEESAKKKELAGDVKASWGDQMRSYVLNPYQMVKDLRTNHEEGNPSAIFDGAIDGFVDAGIRWRADQRHAPADA
>NZ_CP035103.1|WP_109268042.1|1493596_1494757_-|glucose-1-phosphate-adenylyltransferase
MRIPRTLALVLAGGKGSRLGALTEKKVKPALPVAGTYRLIDVALSNLVHSHLSDVWVVEQFLPHSLNQHLANGRPWDLDRTHGGLQVLPPYQGTEGEGFAEGNADSLYRQKDLIRDFAPDLVLVLSADHLYTLNFLDVIDTHLERGADLTVVTTLVDEDPSRYGVVQADDGGRVTGFDYKPDEPRGRLVAAEMFLYDAEKLLEALDLVHEQEGGLEDYGNDLVPWFVAHRRVVEHRLDGYWMDLGTLQSYWTAHMQMLDGDGVALDDPGWPILSAQPQRVPARIAGSAELRGSMVAAGAMVRGAVEHSVLGPGVVVEEGATVRSSVLLDGVRVGAGVTLENVLADTGADISAGAHGAAGAVTLIDGTGAVAATEEFDRGAVLPRGH
>NZ_CP035103.1|WP_138976459.1|1492371_1493517_+|iron-containing-alcohol-dehydrogenase
MDAPVRSVISPGRYVQGPGAIACLGEYLAAVGQTPLVVADDVVWGFVGRDVEASLARAGMATTREAFNGIPSAGEIDRLTAVIRAAGADVAVAVGGGSTIDAVKASGFLAGIRWVSVPTVASTDAPTSALAVVYTDEGVFEEYRFFPRNPDLVLVDSQLVANAPATFLAAGVGDALATWLEARATAASGSLTMAGGTATLTGTALARLSWDVLWDNALVAMDAARDHVVTPALEKVIEANTLLSGLGFESGGLAAAHAVHNGLTAAPQTHGLAHGQKVNIGSITQLVLEGAPSSEIVDFIEFTTRVGLPTTLTEIGLRAEDTEEIRAVARAATVESETIHSMPFTVRADDVAAALTSIERLGRRVRARAGLPEPQPYRHAH
>NZ_CP035103.1|WP_109268044.1|1491334_1492189_+|LamG-domain-containing-protein
MQGVLTLLLALALGIAGLPPSAARDDPGDVLRSAARPLSYDDTVRKDGPAAYWAMRSPGAGTEKDLVGRLHGSYHGKPKRATLPNGDTAADFDGTGQYLQVPDAAAVSAGTRGVLTVEAWMRPDALDFRSQEGSGYVHWMGKGAPRNHEYVARMYSKSNSENRPNRISGYAFNPSGGEGPGSYFQVPVRRGEWIHYVLVINANAKGGNYPHGYTKIYRNGQRMDQDDLEHDGTVVVPRRGSAPFRVGTRDLRSFFDGAVGKVAVYTKELPRKQVEEHYRVMTTR
>NZ_CP035103.1|WP_017833654.1|1490431_1490941_+|hypothetical-protein
MSGRTAGPGPRRDGSRDQNRDHARGEDRDDGQVTILVIGFAVVLLLLTVVVMGVTAVYVGERKLQVLADNAALAAADTFVALEPGTGGAPPVTVLDDDAVAGAATAYLDTVSAWAGTPGLALAAPTGSPDGRTAEVTLAAVVHPPVVNLLVPDGIPITATSEARARLGR
>NZ_CP035103.1|WP_109222182.1|1490066_1490435_+|hypothetical-protein
MGTLLLVPVVYFVLAVAQVQAGAFGVVAAAQQASQVLARAEPGALSDTGLTAAARLAAADQGFAPDRLALRLECSDGACAEPGAVATVHATLEVPLPLVPGFTDLDVAVLTSSATVVIGRYG
>NZ_CP035103.1|WP_017833652.1|1489474_1489882_+|hypothetical-protein
MDEERARPGAGPPGTDRGSAVVEYVMVAGLVAMIFAATLQLALALHVRNTLIDAAAAGARYGTLADRSPEDGVERTRRIVSGALGPRYAQDVVATTAAVGELRTLEITVVSPLPVVALFGPPDSLEVRGHAVLGD
>NZ_CP035103.1|WP_017833651.1|1489247_1489472_+|hypothetical-protein
MTHLHRFAALLGVLTLTLAALRERLAADDPDRGDVPGWVMLTLMSAVLVAGLLLVAQPALEGLFQDAMARVSQN
>NZ_CP035103.1|WP_017833662.1|1499447_1500245_-|histidinol-phosphatase
MRSPSNYTDDLRLAHILADAVDRLTMRRFKAQDLTVETKPDLTPVTDADREAEQLIRTQLGRARNRDAVIGEEYGATGSGARQWVVDPIDGTKNFVRGVPVWATLIALVDEGRPVVGVVSAPALGRRWWAAAGTGAFTGKSLANAQRIHVSQVGRLSDASLSYSSLTGWRDRGVRERFLELTDEVWRTRAYGDFWSYCLLAEGAVDIACEPELSLHDMAALVPVVEEAGGRFTSLEGEPGPFGGNALATNGLLHDEVLGLLATGS
>NZ_CP035103.1|WP_017833663.1|1500317_1501427_-|ribosome-small-subunit-dependent-GTPase-A
MTRRDSVRRDWDESDVRVRPSKTGSRPRTKERPAHEDAVTGRIVTVDRGRYTAILEEDTPGERLVVAVRARELRRRPVVAGDLVGLVGDVSGAPDSLARLVRIEERSTVLRRSADDTDPVERVVVANADQLVVVVAAANPEPRTGFIDRSLVAAYDAGIEPLLCITKTDLRDPAELISHYTALELPVLVSGPARDVPADDDGTTLPLDPALVEALRERLDGHVSVLLGHSGVGKSTLVNALTGADRATGGVNAVTGRGRHTSSSALALKIEDASPGSWIIDTPGIRSFGLAHVDHDRIVESFDELAEAIAECPKGCRHTGTSPGCALDAWVAQGRAGEAGESRLVSLRRLLGAGERPGESREDKELGVQ
>NZ_CP035103.1|WP_109268248.1|1501416_1502796_-|3-phosphoshikimate-1-carboxyvinyltransferase
MPPESSAPAARPDAAEPAPQHELWPAPFVGPRPVVAELTVPGSKSLTNRYLLLAALADGPCRLRSPLHSRDSRLMVEALRALGARVEEVPGDGGFGPDLLVEPAPWDAAEPVTVECGLAGTVMRFVPPVAALARRPVTFDGDPGARVRPMGPVIDALRALGLRVEDDGRGRLPFTVHGTGGVRGGELEIDATGSSQFVSALLLAGARFDDGLVLRHRSADGSGRGVPSMPHVEMTVEVLRGLGVSVDDSVPDEWRVSPGPVRAFDVTIEQDLSNAGPFLAAAVVTGGRVSVPRWPDRTTQGGDHWKHILPAFGAAVELTDGTFTVTGPDAVTGVDLDLGEAGELAPTVAAVCAVAGTPSRLRGIAHLRGHETDRLAALVTEINRLGGDAEETADGLLIRPAPLHGGTFHSYEDHRMATAGAVIGLVVPDVRVENIATTAKTLPEFPRLWAELTGTSRDA
>NZ_CP035103.1|WP_017833665.1|1502816_1503356_-|DoxX-family-membrane-protein
MSIVRRIARPLLATGYVANGVESFRNSSQAAQHLAPAISAATKAFPQAGPALQNHAVVAQGLAAAQLGAAVLFGLGKLPRLSAGVLVTTTALNAYADYRAAEASTPEQKAARRSTAFKNSSLVGAVMLAAVDTEGNPSLLWRAEHLAGDVRKNASKLGKDTQKQVAKAEKALQHAVKQG
>NZ_CP035103.1|WP_017833666.1|1503665_1504334_+|sigma-70-family-RNA-polymerase-sigma-factor
MNEQNQQGAAPQRTEPPVDVETESPEDRKARFEQDAMVYVDQLYAAALRMARNPADAEDLVQEAYTKAFSAFHQYKPGTNLKAWLYRILTNTYINLYRKRQREPLQANTDTVEDWQLHRAESHTSSGLRSAEVEALDHLPDSDVKRALQELPEEFRLAVYFSDVEGFAYKEISEIMDTPIGTVMSRLHRGRKLLREKLADYAAERGFDTSRVTGDKKKEKDK
>NZ_CP035103.1|WP_017833667.1|1504336_1504603_+|mycothiol-system-anti-sigma-R-factor
MADCESLGCCTDERIRLIYEYLDGVLPADDLDEIHGHLLECPECAREYDLECVIRSVVRRSCAETAPADLRVSILARLHGARQDPPAA
>NZ_CP035103.1|WP_031283102.1|1504928_1505528_-|lysophospholipase
MEQRRIRIVAVGDELLAGEGDPRGLGWFGRVMARTPHHVAPVSAYNLAAPGEGSESLNERWFEEAARRFSPGHDNRLVIAPSTLDIDLSITSARSRLNMANIIDTASQHNVRVLVVGPPPTMDAERNRRIADLSAAYADVTTRRNHVYVDTFNPLQHHEQWRKDLAANHGHPGQAGYGLMAWLVLHRGWYDWLDLPEPR
>NZ_CP035103.1|WP_095650608.1|1505661_1509504_-|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit
MPHQPQHPIPEEFAGNEWLVDELFEKYRTDKNSVDEKWWPIFESMSADSSTAPEPSGAAKAPAPKAAPAAAPAQPKAAAPQPPAAQRTAARTSPAPAAKPATAPAPTRSGAKAEGRPETDQGETEASDAKRPIPAQPARARATAPNHDAPAEDKVVKLRGPAKAVAANMDASLTVPTATTVRAVPAKLLIDNRIVINSHLSRNRGGKVSFTHLIGYAVIKALANYPSQNVVYDEQDGKPVAVHPAHVNFGIAIDIPNKDGSRNLVVPNIKGAEAMSFMQFWNAYEDVVRRARANELTMEDYQGTTVSLTNPGGIGTVHSVPRLSKGQACIVGVGALDHPAEYRGSSPKTIARHAVSKIITLTSTYDHRVIQGAGSGEFLRLIESYLLGGDDFYDEIFEALRIPYEPVRWAVDNQVNPEIQVNKVARIQQLIHAYRVRGHLMADTNPLEYVMRKHPDLDIRTYGLSLWDLEREWPTGGFGGADVLSLRTILGRLRDAYCRTLGVEYMHLQEPEEREWFQDQLEHGYQKPSREEQFRILGRLNAAEAFETFLQTKYVGQKRFSLEGGESLIPLLDEIISDAADAGLAGVGIAMAHRGRLNVLTNIAGKSYAQVFREFEGSQDPRTTEGSGDVKYHLGTEGSFTSDNGNETQVYLAANPSHLEAADPVIEGIARAKTDVLGAGPEGDGTFPVLPIQVHGDAAFAGQGVVAEVLQMALLPGYTVGGTVHVVVNNQVGFTTAPAAARSTTYATDIAKGLQAPIFHVNADDPEAVTHVGQMAFAYRQTFHKDVIIDLVCYRRRGHNEGDDPSMTQPLMYNLIEEKRSTRKIYTENLVGRGDITQEEADRALKDYQERLERVFAETHEAQTSSIPLVTGDSAAISNIERPSAQQADSGVSIPRTTAISTEAAQRIGAVHVEVPEDFAVHKKLRKLLERREAMTREGGVDWGMGELMAFGSLMMEGIPVRMSGQDVRRGTFTQRHAVFYDSGTGAEWTPLNHLSGNQAQLAIYNSLLSEYGVLGFEYGYSVERPDALTVWEAQFGDFVNGAQIILDEFVSSAEQKWGQRSSLVMLLPHGFEGQGPDHSSARIERFLTLCAEKNMVVANPSTPSNHFHLLRRQAYSRPRKPLVVATPKQLLRLKAAASPIEEFTSGAFRPVIGDQAGLEAAEVTDVVLVSGRLYYDLAAAREERKDRRTAIVRVEQLYPLPLAEIREELGKYPEARLTWAQDEPANQGAWPFMAVNLLPQLDRPVRLASRPASASPANGSAKRHAAELETLVQTAFERD
>NZ_CP035103.1|WP_017833670.1|1509775_1511233_+|GuaB1-family-IMP-dehydrogenase-related-protein
MRFLNTPTSDLTYSDVFLVPSSSRVTSRFDVDLTPRDGTGATVPLVAANMTAVTGRRMVETLARRGGLGILPQDIPLDVIADVTSWVKERSPRFETPVVLGDEDTVHDALGIMHKRPHGAVVVCGPGRAYRGVVLAADCAEVDRFTQLGSIMRTDAPVFTLAEVRAGSGDDVLAAAYDRLAQTRAHVAPVLDGDTVVGVLTRKGTVRSTIYTPALDGAGRLRVGAAVGINGDVRGKARALLDAGVDVLVVDTAHGHQRKMVEALELVRAAAPDVPVVAGNVVTADGVQDLVDAGADIVKVGVGPGAMCTTRMMTAVGRPQFSAVLECAEAAAGLGRHVWADGGVKHPRDVALALAAGASQVMVGSWFAGTHEGPGELNVDADGRMYKESFGMASTRAVRERTRGEGAFARARKGLFEEGISSSKMYLDPERPGVEDLVDQITAGVRSSMTYAGATTLEQFAARAVVGIQSASGYEEGRARPVSWS
>NZ_CP035103.1|WP_109268040.1|1511427_1512789_+|HlyC/CorC-family-transporter
MEWLLLAAGLLLILGTGFFVAVEFSLVALDQTTVRRAIAEGDRAAEPLLKCLKSLSTQLSSCQLGITLTTLLTGYTLDLALQSFLREPIAELTGLSVAAAGGATLALSMLISTLLSMLLGELVPKNWAIAEAFRVGRLVARPQLVFTAVFKPFVVTLNGVANRVLHLFGMEAKEELSGARSPEELSSMVRRSAKMGTLDAGTAAFVAKTLTFAERTAADVMTPRIRVQMLDSHESVGDVVAVASRTGHSRFPVMDDSPDDVRGVVHVKKAVAVPSERRAALECGAIMEDVLRVPETVHLDSLLVQLRSGGLQMAVVVDEWGGTAGVVTLEDLVEEVVGEVSDEHDRLSLGALQSAAGEWYFPGLMRPDEVSEQITELDIEDGPAYETMGGFMMDRLGQVPKPGDVVPVQGGVLEVARMEGRRVDRIRFVPAPAEPEDAPAGARESGAREEDAR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_CP035103.1	1440269-1440289	0	1.0
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_CP035103.1	998694-998714	1	0.952

1. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to position: 1440269-1440289, mismatch: 0, identity: 1.0

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccaccgccgaa	Protospacer
*********************

2. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to position: 998694-998714, mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgcctccgccgaa	Protospacer
************ ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_LR134455	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 13, complete sequence	232716-232736	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_AP020327	Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p1-JPH1	126121-126141	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NC_008758	Polaromonas naphthalenivorans CJ2 plasmid pPNAP02, complete sequence	144180-144200	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	226169-226189	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_CP011053	Halomonas sp. KO116 plasmid unnamed1, complete sequence	22704-22724	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	433954-433974	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	KY555147	Caulobacter phage Ccr34, complete genome	46151-46171	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	KY555145	Caulobacter phage Ccr29, complete genome	50712-50732	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	KY555143	Caulobacter phage Ccr2, complete genome	46179-46199	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	MK411746	Arthrobacter phage Sonali, complete genome	20847-20867	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	KY555146	Caulobacter phage Ccr32, complete genome	45711-45731	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	JX163858	Caulobacter phage phiCbK, complete genome	162126-162146	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	KY555142	Caulobacter phage Ccr10, complete genome	45704-45724	1	0.952
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	45905-45925	2	0.905
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	644641-644661	2	0.905
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3613354-3613374	2	0.905
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1168441-1168461	2	0.905
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	NZ_AP022319	Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence	61553-61573	2	0.905
NZ_CP035103_2	2.1\|1440224\|21\|NZ_CP035103\|CRISPRCasFinder	1440224-1440244	21	MN692961	Marine virus AFVG_117M41, complete genome	36316-36336	2	0.905

1. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NZ_LR134455 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 13, complete sequence) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccggcgccaccgccgaa	Protospacer
******* *************

2. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NZ_AP020327 (Mycobacterium avium subsp. hominissuis strain JP-H-1 plasmid p1-JPH1) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gcccccgccgccaccgccgaa	Protospacer
***.*****************

3. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NC_008758 (Polaromonas naphthalenivorans CJ2 plasmid pPNAP02, complete sequence) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccaccgccgccaccgccgaa	Protospacer
*** *****************

4. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccgccgccgaa	Protospacer
************.********

5. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NZ_CP011053 (Halomonas sp. KO116 plasmid unnamed1, complete sequence) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccgccgccgccaccgccgaa	Protospacer
*** *****************

6. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccttcgccgccaccgccgaa	Protospacer
****.****************

7. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to KY555147 (Caulobacter phage Ccr34, complete genome) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccgccgccgccaccgccgaa	Protospacer
*** *****************

8. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to KY555145 (Caulobacter phage Ccr29, complete genome) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccgccgccgccaccgccgaa	Protospacer
*** *****************

9. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to KY555143 (Caulobacter phage Ccr2, complete genome) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccgccgccgccaccgccgaa	Protospacer
*** *****************

10. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to MK411746 (Arthrobacter phage Sonali, complete genome) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccaccgccgga	Protospacer
*******************.*

11. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to KY555146 (Caulobacter phage Ccr32, complete genome) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccgccgccgccaccgccgaa	Protospacer
*** *****************

12. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to JX163858 (Caulobacter phage phiCbK, complete genome) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccgccgccgccaccgccgaa	Protospacer
*** *****************

13. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to KY555142 (Caulobacter phage Ccr10, complete genome) position: , mismatch: 1, identity: 0.952

gcctccgccgccaccgccgaa	CRISPR spacer
gccgccgccgccaccgccgaa	Protospacer
*** *****************

14. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 2, identity: 0.905

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccaccgccgcg	Protospacer
******************* .

15. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 2, identity: 0.905

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccaccgccgtt	Protospacer
*******************

16. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 2, identity: 0.905

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccaccgccgcc	Protospacer
*******************

17. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 2, identity: 0.905

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccaccgccgtt	Protospacer
*******************

18. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to NZ_AP022319 (Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence) position: , mismatch: 2, identity: 0.905

gcctccgccgccaccgccgaa	CRISPR spacer
acctccgccgccaccgccgac	Protospacer
.*******************

19. spacer 2.1|1440224|21|NZ_CP035103|CRISPRCasFinder matches to MN692961 (Marine virus AFVG_117M41, complete genome) position: , mismatch: 2, identity: 0.905

gcctccgccgccaccgccgaa	CRISPR spacer
gcctccgccgccaccgccgcc	Protospacer
*******************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

387065 : 453970

Streptococcus_phage(20.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_109269425.1\|387065_387898_-\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_126346842.1\|388022_388574_-	hypothetical protein	NA	NA	NA	NA
WP_109269423.1\|388834_389518_-	response regulator transcription factor	W8CYM9	Bacillus_phage	4.5e-26	31.5
WP_167508847.1\|389514_391407_-	DUF4118 domain-containing protein	A0A1V0SGX0	Hokovirus	2.9e-06	24.4
WP_167508848.1\|391714_393112_-	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_109269420.1\|394225_394588_-	hypothetical protein	NA	NA	NA	NA
WP_109269419.1\|395161_395596_-	ATP-binding protein	NA	NA	NA	NA
WP_109269418.1\|395588_395921_-	STAS domain-containing protein	NA	NA	NA	NA
WP_126346845.1\|396332_396710_+	hypothetical protein	NA	NA	NA	NA
WP_109269416.1\|397190_397520_+	hypothetical protein	NA	NA	NA	NA
WP_126346846.1\|397729_397957_-	hypothetical protein	NA	NA	NA	NA
WP_126346847.1\|398272_398728_-	hypothetical protein	NA	NA	NA	NA
WP_109269413.1\|399135_399333_+	hypothetical protein	NA	NA	NA	NA
WP_126346848.1\|399535_400345_+	hypothetical protein	NA	NA	NA	NA
WP_109269411.1\|400595_401081_+	hypothetical protein	NA	NA	NA	NA
WP_109269410.1\|401159_401390_+	hypothetical protein	NA	NA	NA	NA
WP_126346849.1\|401775_402000_+	hypothetical protein	NA	NA	NA	NA
WP_138976440.1\|402007_403639_+	hypothetical protein	NA	NA	NA	NA
WP_109269408.1\|403817_404456_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_109269407.1\|404636_406049_-	PLP-dependent aminotransferase family protein	A0A1X9I5H2	Streptococcus_phage	1.4e-10	27.5
WP_109269406.1\|406047_407028_+	DMT family transporter	NA	NA	NA	NA
WP_109223276.1\|407017_408265_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.2e-80	41.4
WP_109269521.1\|408457_408967_-	serine acetyltransferase	NA	NA	NA	NA
WP_109269522.1\|409209_410013_-	IclR family transcriptional regulator	NA	NA	NA	NA
WP_109269523.1\|410309_411572_-	M24 family metallopeptidase	NA	NA	NA	NA
WP_109269524.1\|411657_412995_-	MFS transporter	Q6JIH2	Burkholderia_virus	6.2e-64	37.0
WP_109244589.1\|413378_414011_-	response regulator transcription factor	NA	NA	NA	NA
WP_109269525.1\|414007_415306_-	sensor histidine kinase	NA	NA	NA	NA
WP_109269526.1\|415549_416644_+	ABC transporter permease	NA	NA	NA	NA
WP_109269527.1\|416646_417402_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.5e-24	35.8
WP_138976501.1\|418631_420182_+\|transposase	transposase	NA	NA	NA	NA
WP_109269553.1\|420698_421709_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	7.5e-38	34.5
WP_031283557.1\|421996_422389_-	large conductance mechanosensitive channel protein MscL	NA	NA	NA	NA
WP_017834502.1\|422782_422983_-	antitoxin	NA	NA	NA	NA
WP_081994608.1\|424693_426274_-\|transposase	IS30 family transposase	Q9MBM9	Staphylococcus_prophage	2.1e-34	33.0
WP_109244524.1\|427253_427784_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_017834499.1\|428294_428693_+	hypothetical protein	NA	NA	NA	NA
WP_109269490.1\|428791_429280_-	hypothetical protein	NA	NA	NA	NA
WP_109244523.1\|429573_430398_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
WP_017834496.1\|430513_430753_+	heavy-metal-associated domain-containing protein	NA	NA	NA	NA
WP_017834495.1\|430966_432895_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	3.2e-101	39.7
WP_017834494.1\|433009_433438_+	cupin domain-containing protein	NA	NA	NA	NA
WP_109269491.1\|433482_434400_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_017834492.1\|434551_434746_+	hypothetical protein	NA	NA	NA	NA
WP_109269492.1\|434864_436100_-	cytochrome P450	NA	NA	NA	NA
WP_058874012.1\|436179_437424_-	NarK/NasA family nitrate transporter	NA	NA	NA	NA
WP_109244522.1\|437460_438294_-	respiratory nitrate reductase subunit gamma	NA	NA	NA	NA
WP_017834488.1\|438290_438989_-	nitrate reductase molybdenum cofactor assembly chaperone	NA	NA	NA	NA
WP_109269493.1\|438988_440659_-	nitrate reductase subunit beta	A0A077SL61	Escherichia_phage	1.3e-18	43.5
WP_109269494.1\|440658_444378_-	nitrate reductase subunit alpha	NA	NA	NA	NA
WP_058874006.1\|444800_445922_+	GTP 3',8-cyclase MoaA	NA	NA	NA	NA
WP_031283581.1\|446021_446297_+	MoaD/ThiS family protein	NA	NA	NA	NA
WP_051063819.1\|446293_446887_+	NTP transferase domain-containing protein	NA	NA	NA	NA
WP_058874004.1\|446915_447206_+	hypothetical protein	NA	NA	NA	NA
WP_109223112.1\|447520_447988_-	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_109269495.1\|448013_449216_-	hemin transporter	NA	NA	NA	NA
WP_058874019.1\|449394_449727_-	hypothetical protein	NA	NA	NA	NA
WP_109269496.1\|449906_452585_-	multicopper oxidase domain-containing protein	NA	NA	NA	NA
WP_138976441.1\|453075_453970_-\|transposase	IS5 family transposase	NA	NA	NA	NA

DBSCAN-SWA_2

2720501 : 2776682

Bacillus_phage(15.38%)

tRNA,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_109269536.1\|2720501_2720927_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	7.1e-30	44.2
WP_109269537.1\|2721054_2721883_+\|transposase	IS5 family transposase	NA	NA	NA	NA
WP_126346459.1\|2722112_2723123_+\|transposase	IS481 family transposase	NA	NA	NA	NA
WP_167508889.1\|2723234_2723486_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_138976475.1\|2723553_2724735_-	hypothetical protein	NA	NA	NA	NA
WP_138976476.1\|2725077_2726550_-	hypothetical protein	NA	NA	NA	NA
WP_109269538.1\|2727584_2728370_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	6.3e-24	32.9
WP_109269539.1\|2728366_2729941_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_167508890.1\|2731346_2732033_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_109269470.1\|2731987_2733058_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_109269471.1\|2733351_2734498_+\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	1.0e-22	30.5
WP_167508891.1\|2736258_2736909_-	glycosyltransferase	NA	NA	NA	NA
WP_167508892.1\|2737396_2738173_-	WecB/TagA/CpsF family glycosyltransferase	NA	NA	NA	NA
WP_109269474.1\|2738777_2739797_+	GDP-mannose 4,6-dehydratase	M4QRT5	Synechococcus_phage	2.8e-109	59.9
WP_109269475.1\|2739823_2740828_+	GDP-L-fucose synthase	D1LW79	Prochlorococcus_phage	7.4e-94	53.5
WP_109269476.1\|2741037_2741616_-\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_109269477.1\|2741722_2742334_-	50S ribosomal protein L25/general stress protein Ctc	NA	NA	NA	NA
WP_109269478.1\|2742780_2744331_+	sugar transferase	NA	NA	NA	NA
WP_167508893.1\|2744476_2744815_-	WecB/TagA/CpsF family glycosyltransferase	NA	NA	NA	NA
WP_167508894.1\|2744760_2745276_-	hypothetical protein	NA	NA	NA	NA
WP_109269480.1\|2745626_2747111_+	sugar transferase	NA	NA	NA	NA
WP_109269481.1\|2747135_2747552_-	hypothetical protein	NA	NA	NA	NA
WP_167508895.1\|2747773_2748394_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_109243337.1\|2748587_2749004_+	VOC family protein	NA	NA	NA	NA
WP_109269483.1\|2749361_2749823_+	hypothetical protein	NA	NA	NA	NA
WP_109269484.1\|2750140_2751649_+	sugar transferase	NA	NA	NA	NA
WP_109269485.1\|2751759_2753256_+	lipopolysaccharide biosynthesis protein	NA	NA	NA	NA
WP_167508896.1\|2753470_2754076_+	polysaccharide pyruvyl transferase family protein	NA	NA	NA	NA
WP_167508897.1\|2754308_2755160_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_109269488.1\|2756820_2758128_-	oligosaccharide repeat unit polymerase	NA	NA	NA	NA
WP_109269489.1\|2758383_2759007_-	SGNH/GDSL hydrolase family protein	A0A0A0RS52	Bacillus_phage	8.8e-05	32.2
WP_109223276.1\|2759149_2760397_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.2e-80	41.4
WP_109269245.1\|2761274_2762525_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	3.0e-76	44.1
WP_167508898.1\|2762880_2763201_-\|transposase	transposase family protein	A0A2H4PDF8	Mycobacterium_phage	1.8e-06	40.2
WP_138976478.1\|2765025_2765244_-	hypothetical protein	NA	NA	NA	NA
WP_138976479.1\|2765240_2766347_-	glycosyltransferase	NA	NA	NA	NA
WP_167508899.1\|2766343_2767474_-	glycosyltransferase	NA	NA	NA	NA
WP_109269249.1\|2767485_2768103_-	acetyltransferase	NA	NA	NA	NA
WP_167508900.1\|2768243_2769479_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_109269251.1\|2769558_2770590_+	GDP-mannose 4,6-dehydratase	M4QRT5	Synechococcus_phage	1.1e-108	59.8
WP_109269252.1\|2770604_2771606_+	GDP-L-fucose synthase	D1LW79	Prochlorococcus_phage	9.6e-94	52.6
WP_109269254.1\|2772281_2773355_+	CpsD/CapB family tyrosine-protein kinase	NA	NA	NA	NA
WP_138976481.1\|2773671_2774022_+	hypothetical protein	NA	NA	NA	NA
WP_109269255.1\|2774218_2774626_-	VOC family protein	NA	NA	NA	NA
WP_035926607.1\|2774622_2774916_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_109269256.1\|2775136_2775439_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_109269257.1\|2775462_2776065_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	2.6e-38	42.2
WP_109269258.1\|2776061_2776682_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A1S6UA97	Serratia_phage	2.3e-21	38.2

DBSCAN-SWA_3

2989184 : 2996505

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_109268838.1\|2989184_2989907_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.5e-35	38.3
WP_017832746.1\|2989919_2991386_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	6.2e-25	29.2
WP_017832747.1\|2991395_2992418_-	DUF4440 domain-containing protein	J9Q745	Salmonella_phage	7.2e-20	42.7
WP_095650865.1\|2992478_2993174_-	MgtC/SapB family protein	G3MA03	Bacillus_virus	1.1e-16	41.0
WP_035926880.1\|2993336_2994968_-	chaperonin GroEL	A0A240F779	uncultured_virus	1.2e-146	53.6
WP_109243242.1\|2995218_2995842_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_109268839.1\|2995945_2996164_-	hypothetical protein	NA	NA	NA	NA
WP_109268848.1\|2996160_2996505_-	DUF3263 domain-containing protein	A0A0A7RXU7	Mycobacterium_phage	8.6e-10	53.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP035103

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection