CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP019734	Alistipes onderdonkii subsp. vulgaris strain 3BBH6	4 crisprs	DEDDh,cas3,RT,PrimPol	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP019734_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019734_1

1177915-1178040

Orphan

Consensus_repeat	Method
GCAAAGATAGTGCAAGCCGAGTGCAGATGCAAGCTCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019734_1

>merge|NZ_AP019734|1|1177915-1178040|CRISPRCasFinder
GCAAAGATAGTGCAAGCCGAGTGCAGATGCAAGCTCTGCTTGCAATATGCCGAGGCGCCGCCTGTCTAAGCCGAAATTCCTTTTGAGGCAAAGATAGTGCAAGCCGAGCGCAGATGCAAGCTCTGC

>NZ_AP019734|1|1|1177915-1178040|CRISPRCasFinder
GCAAAGATAGTGCAAGCCGAGTGCAGATGCAAGCTCTGC	TTGCAATATGCCGAGGCGCCGCCTGTCTAAGCCGAAATTCCTTTTGAG
GCAAAGATAGTGCAAGCCGAGCGCAGATGCAAGCTCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019734.1\|WP_117507379.1\|1186142_1186778_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_AP019734.1\|WP_141418040.1\|1178122_1179241_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_117507384.1\|1180938_1182210_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341066
NZ_AP019734.1\|WP_018696544.1\|1174283_1174970_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_AP019734.1\|WP_141417717.1\|1176489_1177899_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|225174
NZ_AP019734.1\|WP_018696545.1\|1175000_1175456_-\|cytidine-deaminase	unknown	unknown	gnl\|CDD\|273572
NZ_AP019734.1\|WP_117507381.1\|1184661_1185801_+\|lipid-A-disaccharide-synthase	unknown	unknown	gnl\|CDD\|234580
NZ_AP019734.1\|WP_026318497.1\|1170430_1171327_-\|YitT-family-protein	unknown	unknown	gnl\|CDD\|224203
NZ_AP019734.1\|WP_117507392.1\|1171338_1172295_-\|TIGR01212-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|224163
NZ_AP019734.1\|WP_117507391.1\|1172297_1173803_-\|DNA/RNA-non-specific-endonuclease	unknown	unknown	gnl\|CDD\|366523
NZ_AP019734.1\|WP_130064628.1\|1173815_1174271_-\|D-tyrosyl-tRNA(Tyr)-deacylase	unknown	unknown	gnl\|CDD\|376833
NZ_AP019734.1\|WP_141417716.1\|1175613_1176303_-\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225516
NZ_AP019734.1\|WP_018695795.1\|1182946_1183624_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	unknown	unknown	gnl\|CDD\|234581
NZ_AP019734.1\|WP_018696538.1\|1167469_1168192_-\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_AP019734.1\|WP_117507380.1\|1185810_1186122_+\|DUF3784-domain-containing-protein	unknown	unknown	gnl\|CDD\|378903
NZ_AP019734.1\|WP_141417715.1\|1168175_1170431_-\|primosomal-protein-N'	unknown	unknown	gnl\|CDD\|235514
NZ_AP019734.1\|WP_117507383.1\|1182225_1182957_+\|FkbM-family-methyltransferase	unknown	unknown	gnl\|CDD\|273628
NZ_AP019734.1\|WP_117507382.1\|1183633_1184665_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173818
NZ_AP019734.1\|WP_055201570.1\|1180263_1180932_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_AP019734.1\|WP_117507385.1\|1179285_1180110_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730

Protein	Function_ID	Function_description	E-value
NZ_AP019734.1\|WP_117507379.1\|1186142_1186778_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.99229e-67
NZ_AP019734.1\|WP_055201570.1\|1180263_1180932_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	4.02609e-68
NZ_AP019734.1\|WP_117507384.1\|1180938_1182210_+\|hypothetical-protein	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	6.34838e-22
NZ_AP019734.1\|WP_117507385.1\|1179285_1180110_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	4.79434e-22
NZ_AP019734.1\|WP_141417717.1\|1176489_1177899_-\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	7.31915e-120
NZ_AP019734.1\|WP_018696545.1\|1175000_1175456_-\|cytidine-deaminase	gnl\|CDD\|273572	TIGR01354, Cytidine_deaminase, cytidine deaminase, homotetrameric. This small, homotetrameric zinc metalloprotein is found in humans and most bacteria. A related, homodimeric form with a much larger subunit is found in E. coli and in Arabidopsis. Both types may act on deoxycytidine as well as cytidine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides].	7.45591e-31
NZ_AP019734.1\|WP_117507382.1\|1183633_1184665_+\|S8-family-serine-peptidase	gnl\|CDD\|173818	cd07493, Peptidases_S8_9, Peptidase S8 family domain, uncharacterized subfamily 9. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.2955e-48
NZ_AP019734.1\|WP_117507381.1\|1184661_1185801_+\|lipid-A-disaccharide-synthase	gnl\|CDD\|234580	PRK00025, lpxB, lipid-A-disaccharide synthase; Reviewed.	1.25413e-99
NZ_AP019734.1\|WP_026318497.1\|1170430_1171327_-\|YitT-family-protein	gnl\|CDD\|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	4.29899e-50
NZ_AP019734.1\|WP_117507392.1\|1171338_1172295_-\|TIGR01212-family-radical-SAM-protein	gnl\|CDD\|224163	COG1242, COG1242, Predicted Fe-S oxidoreductase [General function prediction only].	2.51311e-109
NZ_AP019734.1\|WP_117507391.1\|1172297_1173803_-\|DNA/RNA-non-specific-endonuclease	gnl\|CDD\|366523	pfam01223, Endonuclease_NS, DNA/RNA non-specific endonuclease.	7.29852e-21
NZ_AP019734.1\|WP_130064628.1\|1173815_1174271_-\|D-tyrosyl-tRNA(Tyr)-deacylase	gnl\|CDD\|376833	pfam02580, Tyr_Deacylase, D-Tyr-tRNA(Tyr) deacylase. This family comprises of several D-Tyr-tRNA(Tyr) deacylase proteins. Cell growth inhibition by several d-amino acids can be explained by an in vivo production of d-aminoacyl-tRNA molecules. Escherichia coli and yeast cells express an enzyme, d-Tyr-tRNA(Tyr) deacylase, capable of recycling such d-aminoacyl-tRNA molecules into free tRNA and d-amino acid. Accordingly, upon inactivation of the genes of the above deacylases, the toxicity of d-amino acids increases. Orthologues of the deacylase are found in many cells.	8.13485e-82
NZ_AP019734.1\|WP_141417716.1\|1175613_1176303_-\|SIMPL-domain-containing-protein	gnl\|CDD\|225516	COG2968, COG2968, Uncharacterized conserved protein [Function unknown].	1.14016e-12
NZ_AP019734.1\|WP_018695795.1\|1182946_1183624_+\|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD	gnl\|CDD\|234581	PRK00026, trmD, tRNA (guanine-N(1)-)-methyltransferase; Reviewed.	1.10784e-129
NZ_AP019734.1\|WP_018696538.1\|1167469_1168192_-\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	6.17554e-36
NZ_AP019734.1\|WP_117507380.1\|1185810_1186122_+\|DUF3784-domain-containing-protein	gnl\|CDD\|378903	pfam12650, DUF3784, Domain of unknown function (DUF3784). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 96 and 110 amino acids in length.	1.62245e-14
NZ_AP019734.1\|WP_141417715.1\|1168175_1170431_-\|primosomal-protein-N'	gnl\|CDD\|235514	PRK05580, PRK05580, primosome assembly protein PriA; Validated.	0
NZ_AP019734.1\|WP_018696544.1\|1174283_1174970_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	9.20528e-56
NZ_AP019734.1\|WP_117507383.1\|1182225_1182957_+\|FkbM-family-methyltransferase	gnl\|CDD\|273628	TIGR01444, 2-O-methyltransferase_NoeI, methyltransferase, FkbM family. Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.	2.41836e-23

>NZ_AP019734.1|WP_141417717.1|1176489_1177899_-|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MARKKANYPLIEGLEITTLAAEGKAMGRWNDVVVFVPLTVPGDVVDVQIRSKRRRFMEGFVVRYVKKSPLRAEAFCEHFGVCGGCKWQNLPYEEQLRFKTGQVRDQLARIGKIALPEIAPCLGSARTQFYRNKLEFTFADRRWLTREEVEGGADIGAAPALGFHIPGMFDKVLDIRKCWLQPDPSNDIRMETRRFCVENGYTFHNAREHTGLMRNMIVRTASTGEVMVTVVFGADDRERIAALLDHLAAVFPQITSLCYIVNTKLNDSVGDLDPVCYKGKDHIVEEMEGLRFKVGPKSFYQTNSEQAYELYKVAREFADLKPEDVLYDLYTGTGTIANFCAAHCRRVVGIEYVPEAIADAKINSEINGIGNTAFYAGDMKQVLSDEFVAANGRPDVVILDPPRAGVDEPVIGVILRAAPERIVYVSCNPATQARDLALLDADYRVEAVQPVDMFPHTHHVENVVKLVRR
>NZ_AP019734.1|WP_141417716.1|1175613_1176303_-|SIMPL-domain-containing-protein
MKKLILIAAVALMALPAAAQVQEAFPSYIQVNGRAEKEIMPDEFYLSVIINERDSKGKISVESQQRDMIAALKRLGVNVEKQLKVANLSSEFFKKNTSVATAKYQLQLGSAAEVSKVWQALDNLGISNVSILKVSHSKIDQYKEQVRVEAMQNAKQSAQTLAQAIGQSVGKCFYIYDSNNNVMPVFYDNMAVMRSAKAAGLAEDAAADEPLDFKTIKLQYNVQAKFVLE
>NZ_AP019734.1|WP_018696545.1|1175000_1175456_-|cytidine-deaminase
MEKQFCFNYEHYAALEGLPDADRKLVAEAQRATANAHAPYSHFQVGAAARLRSGKILYGSNFESEVYPAGLCAERSLMFYAQANYADDPIETLAIASNPSARECYPCGQCRQVMVDVERRQGSPMRVIMSGNGTATVVDTAARLLPFTFVL
>NZ_AP019734.1|WP_018696544.1|1174283_1174970_-|RluA-family-pseudouridine-synthase
MFTPEDILYEDNHLLVVNKHCGDLVQPDPSGGSALEDQIKAFIKRRDAKPGEVFLGVVHRIDRPVSGAVLFAKTSKALTRLNEMIREGRIRKIYWALTEQAPDPLSGELCHYILRDGRANRSRACDAPKADAKQARLRYATLGAGTHYTLVEVELLTGRHHQIRAQLSKIGCPIRGDLKYGARRSLPGGGISLHSRSVEFEHPVRHEPVAVTAPVPADDNLWAYFENR
>NZ_AP019734.1|WP_130064628.1|1173815_1174271_-|D-tyrosyl-tRNA(Tyr)-deacylase
MRILIQRVKSASVTIGGQLRSQIGAGLLVLLGVGADDTDEDVEYLAGKLVRLRIFDDAQGVMNLDVRQAGGQVLVVSQFTLLASTRKGNRPSYIKAAPEAVSRPMYERFAARVAELLGREVMTGEFGADMQVALVNDGPVTIWIDSKMRDC
>NZ_AP019734.1|WP_117507391.1|1172297_1173803_-|DNA/RNA-non-specific-endonuclease
MKRFLVVLCAGMAAFFASCNDEETGKENKWFFAPEAGVSGTTVEVSCRTKFGDGVLSSAQAGFAYAPIRSDNTGSFTETTDVTVDGQVMSCRLTGLDAETSYLIYAFVDMGSGGRMQSKPVVVKTGVDPVLPDDPRFGVPECSQVTASSATVSCTFDYTGGKEVSEAYFLYGTATSDDGQLVAVTTEPGAKSATLTGLSASTKYKFRLCVVVGGETFGSTVGTFATSAAGGGDGRTKYAGWAELPVEAENGDYHYAYHICPDFKVDGHEARNFTVCYSAEHHSPVWVAAPVHNCYVGSSGNRNYGPDPVIPSSIQPSGSKASMGSPYNRGHMLGNHERSRTSGMNKQVSYYTNIAAQHGSTFNTGDGAWNNLEDKIDDYWCADTLYVVVGAYYDKWTDSYGNSAPQRSTSFGNITTDVPTMFYTLCLRTKKGNTNKSVMNCAADELQCAAFVMSHAMGKGHDPQAGDMRSVKEIEELTGFTFFANVPNAPKDTYNASDWGL
>NZ_AP019734.1|WP_117507392.1|1171338_1172295_-|TIGR01212-family-radical-SAM-protein
MYAWGDHRRFNSYSGYFRRTFGGRVQKISVDAGFTCPNRDGKISEGGCTFCNNGAFTPSYCIPAKSIGQQIAEGIEFHGRRYRAASRYLVYFQSFSNTYAPLERLRALYGEALAYPGVAGIVIGTRPDCVDAEKLDYLAEIARDRYVAVEFGIESTCDETLRAVNRGHDFACARRAVEMAAERGLHVGAHFILGLPGETDEMLLEQVATINSLPLTTVKFHQLQVFRGTPMAAQYDADPRRFRFWEVGQYIDLFVEILRRLRPDLVVERFASEAPPRYHYGRNWGLIRNETLLAMLEKRLEERGAYQGEIFIPLCSNH
>NZ_AP019734.1|WP_026318497.1|1170430_1171327_-|YitT-family-protein
MKPITMEQVLKTFKEYFLMTVGMMLYSFAWIGCIMPADGTGGGATGLSRVLCHAVEHWAGISIQIGTMAFLINGVLLLVAGFIIGWNFGVKTVFCVCVISLGLNFWQSVLPEGDFLHLERILSVILGGILAGIGVAICFMQGGSTGGTDIAAMIINKYRTISYGKIVIYSDFVIIGSSMLVGFHIDTVIYGYVMTAVFGYTVDMIMAGNQQSSQVFIVTHDYEKMAQAIVDNIHRGVTLIDSQGWYTKKESKIVMVVCRKRETTMILKFVKTIDPEAFMTVGSVMGVYGKGFQAISKP
>NZ_AP019734.1|WP_141417715.1|1168175_1170431_-|primosomal-protein-N'
MPLYADIVLPLAQPAYTFAVPEGMHVEAGQAVAVQFGARKFYTGIVWRVHDRRPPFKTVKSIQRVLYGAPLLSAQQMAFWEWVAAYYMCTPGEVMRVGLPSLMKPSGDTEEEFTEEEFRPRTECYVALAPGLHDEGRLHEAFEKLERRAPRQYEALLELASAGDGERIPTGEVARRLLRADYAVLHALERKGYIVSAERERSVERGGSAFRLPELTPAQLAALESLRGQFARKPAALLHGITGSGKTEVYIHLIAEVLARGGDVLLLVPEIALTAQLIERMERIFGSRVTPYHSKLTNRRRTETYLRLNRSQGGEFVVGVRSSIFLPLKRLQLVVVDEEHDASYKQADPAPRYNARDCAVVMARLWGGRTLLGSATPSLETWVNAGSGKYGLASLTERYGDARPPEIFVSDTIRAAKRGERHAHFNKLLLDKMEAALGRGEQVMLFQNRRGFAPYVECSECGWTARCPHCNVTLTYHKGGGKLVCHYCGYTAPVPVKCPSCKVTDVVPRGFGTEKVEEEIARLFPAARVARLDRDSVTSERAFNAIIADFEARKTDILVGTQMITKGFDFGGVSLVGILNADNLLNNPDFRAAERAFQLMMQVAGRAGRRSDGGEVVIQTSEPGHPVIRQVAAGDYDGMARAQLAEREAFFYPPYARLTLLTLRHRDVALLRRGITELAARLRGRFGRRVLGPMTPPVDRIRGEYLAGLLLKVESGASSARARELLGAELKAFSEDPEFRNITVVVNVDPQ
>NZ_AP019734.1|WP_018696538.1|1167469_1168192_-|ComF-family-protein
MSILSSLLRDVAALFFPPRCPVCGRMLAQGEHTVCTLCRATAPLTGFWRQADNPVLGRCRDMLPVERASGLLYYVHGSGWRELIRGFKYRGAWRTARAMGEWYGRCLKESGLYDDVEVVVPLPLHPVKRCRRGYNQSEYIAEGIAAQLGVEVDRRSVRRKRNTESQALKARRDRARNVEDAFAVGRPGRLAGRHVLLVDDVFTTGSTMLSCAGEILRSAPGCRISIAALAVSRHALGEKG
>NZ_AP019734.1|WP_141418040.1|1178122_1179241_-|hypothetical-protein
MAAAALFAALALTGCSLLKVAVATGDPLSKEEMNIRTMTRGFYYDMASEVSRTADSIAAAAPDIATRVAAVRWKIRATRAGVSAAMQGIPDVALADMWILCRRMDEGFAAAPDSLLFGAQSDLARDAAARLDRRAARLARQVLAVDRYGLMERFVADYVRENPADGEMEGSNTTLAWIEFLRANGIEHAYATGSIAEVLSDVNDRVSGQTQQLANSVGWSKDLIAMQLQQDSMRMEVGARLDSLERNFTRIVVVAEHLPEISDKVLEELNEQVTQLIYTMNYSLDNAFANFDRQRDELQRYVTAERQALVDQLRESADGVVQRTLDAVPGLVGKVLLYVVLALVVLVGGPFALGFWLGGVRERGRRKREKGA
>NZ_AP019734.1|WP_117507385.1|1179285_1180110_-|alpha/beta-hydrolase
MKRLVTLFFVLAVCGTGAVAQEGAYKTVKDIAYRDAAGDGNIDTMCRLDIYYPVGKTGFSTVVWYHGGGLTGGRREIPEALKDKGLAVVGVEYRLSPAVKVADCVDDAAAAAAWVVKHIASYGGDPGRVFVAGHSAGGYLTSMIGLDKRWLEPYGIDPDTAFVALIPYSGQVVTHFERRRELGLPDTQPLVDDMAPLSYVRPDCRPILILSGDREREMLGRYEENAYFWRMMRVAGHPDVRICEFDGFDHGNMPQAGHFVAVRYIREMERRMDR
>NZ_AP019734.1|WP_055201570.1|1180263_1180932_+|MBL-fold-metallo-hydrolase
MKIACLQFNPIQENTYVVWDDTLEAVVIDAGNSNPREDAALDNFIAEHGLRPVLAANTHGHFDHTLGVAHLKKRYGIPFAMSLKDAFLLDNASTSGSIFGVPVGEMPSVDTDLDTTPEIRFGHTVLRVLRTPGHTPGHVALYEPQSKSLFTGDTLFRESIGRTDLPGGDYSWIMRSILDILLPLGDEVHVYPGHGPESTIGHEVLYNPFIVEVLNEEVNYKD
>NZ_AP019734.1|WP_117507384.1|1180938_1182210_+|hypothetical-protein
MKLRIAITCLSACLLPAPALRAQDSPRVACYDLTVRIDVPERRVTVGGSFDVNFLGSDSIALVLWRHARIDTMRCDGHEAVYRFDTLAPAPIRFIPDGRALTLYRPAGSPDRCRIGTRYTLDMHEVQGPAKSFNDRWIEIGYYTGWYPVCNGTSADRSHLRIGITDGYTVSGSGIISRTDDGMWEMDQPWEGFDNVILASPVLKTRRMSDNGTTIEFIYTNFPDADAESALNCSYDALKFFRRLYKIAGEENTYIKFSLSASGTSGGYSRKNFITLNSGSFNEYILRNTAHEISHFWWNKAPVESWHDWLNESFAEFSALQYLRHARGEEAYAERVEMYREKTRRIRPIWGIDRADREAHTALYEKGSVLLADLLVRVGEEPFFDFLAAVIRARIADTPAFLDLAETRLGLENRNWIEQRLKQ
>NZ_AP019734.1|WP_117507383.1|1182225_1182957_+|FkbM-family-methyltransferase
MKTLIHKILYKTLPLEGYLRAVSRMFFLWQRLGIGRYAPATEYVYHLPQLVHAGDTAIDIGANLGYYARTLSRLAGGAGRVYAVEPVPPILSVLRRNLRRCPNVEILPYALGTEDKAVTMANDSARATGYFGTGQNFVNDGGTSAAAEFPARMRRGSELFAGLERLDFIKCDIEGYEVVVMNELRPLLERFRPTVLIETGGENRPQIVALFTALGYAGFTLDRGREIPLAPNTTKDIIFRHAH
>NZ_AP019734.1|WP_018695795.1|1182946_1183624_+|tRNA-(guanosine(37)-N1)-methyltransferase-TrmD
MRIDILTVVPELLTSPLNESILHRAQEKGLVRIVVHNLHDYAHDRRKTTDDYPFGGEAGMVLKCEPVFELVEKLQSERHYDEIIYTSPDGIRYDQHEANRLSTLENIIILCGHYKGIDHRIREHLVTREISIGDYVLTGGELAACIIADSVVRIIPGAIGDEASALTDSFQDNLLAPPVYTRPAEFRGWRVPDVLLSGNFAQIARWQDEQSLERTRQLRPDLLGE
>NZ_AP019734.1|WP_117507382.1|1183633_1184665_+|S8-family-serine-peptidase
MKRKTSLIVWGAVLLLAAYGIYDIVREIRRSYTSCYAHTYSHAIGQMMGPRFDSLAPRGEGIRIGVVDAGFGGLRDDRFTRRLRVADYLDLTDGDTTGFFRDDCDHGTRVTRNIGGFSNDTLLGLACKADYYLVKSDLEHGEPREDERRLCRALAWLAQRQVDVVNISLGYTVFDDFDGYTPQMLDGRTALCSRFLDSLLDAHPRMVVVQSAGNEGKNKWRHISFPGDVAEAVTVGAADSEGTGRSGKSGTGYYPHPVKPDLVVYDSPNGTSFSTPVVTGLCAALMGYRPMKRRELIRLLHASGTRSAAPDLETGYGIPQCDTLLGFLDTPAELQTLPLNATQ
>NZ_AP019734.1|WP_117507381.1|1184661_1185801_+|lipid-A-disaccharide-synthase
MKYYLIAGEPSGDLHGSNLIKGLLKADPEARLRFWGGDLMAAAGGEANLAKHYRETSFFGIVQVLKNLRTIKRQMRECRADVAAFAPDVLILVDYPGFNMKMARWAKEHGIRTFYYIAPKVWAWREWRVKAIRRWVDRLFVIFPFECGYFPRHGVEPIFEGNPLVDAIEARRTSLPSPDEFRRRHGLDRRPIIALLAGSRRGEIRDNLPLMADLSRKFPEHQFVVAGVAWLDRALYEQYMAGSGIRYVCDQTYETLAAAEAAVVTSGTATLETALLGIPEVVVYRTLWFQVRLRPYVLKVPWVSLVNLNLGREAVAEVIQSDLDTTRAERELRAIVAGGEKRGRMLADFAELRTVIGGPGASDRFAARMVAELRAPETK
>NZ_AP019734.1|WP_117507380.1|1185810_1186122_+|DUF3784-domain-containing-protein
MDDFTILLLGGPLLIVVGLLVKRFPMLIAGYNTMPPAKKKNVDIGGLSSFMRRHLVIMGALWILFTVVLELTGLTDTLAVIYVIYLLPYVVWMLVRAQRYDHN
>NZ_AP019734.1|WP_117507379.1|1186142_1186778_+|fumarylacetoacetate-hydrolase-family-protein
MKIICIARNYAAHAEELGRLAGGGTACPPEPAWFLKPDTALLRNNDPFYIPAFSQEVHYECELVVRINRVGKGIAERFAHRYYDQVGLGIDFTARDLQRQAIAEGLPWERCKAFDRSAALSPQFVSLQELGGDVQSLHFTLEVNGQTRQRGDTSGMLFSVDRIIASVSQYMTLRMGDLLYTGTPAGVGPVRPGDNLRAVLEGRELLNFDIR

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Crispr_ID: NZ_AP019734_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019734_2

1253727-1253909

Orphan

Consensus_repeat	Method
AAACAAAAAACGCAAAAATGGTAACACACA	PILER-CR

2 spacers

The CRISPR arrays of NZ_AP019734_2

>merge|NZ_AP019734|2|1253727-1253909|PILER-CR
AAGCGCAAAAATGGTAACACTGATGAGAGCAAAACTCAAAAAATATACATAAAAATATGTATATCAGTAAATTACAAATAGAATATGCAAAAATGGTAACACACAGACATCCCTAAATATCCTATGCTATTTCCAAAATATCAGCATATTGCAACACAAAAAACGCAGAAATGGTAACACAGA

>NZ_AP019734|2|1|1253727-1253909|PILER-CR
AAGCGCAAAAATGGTAACACTGATGAGAGC	AAAACTCAAAAAATATACATAAAAATATGTATATCAGTAAATTACAAATAGAATA
TGCAAAAATGGTAACACACAGACATCCCTA	AATATCCTATGCTATTTCCAAAATATCAGCATATTGCAACACAAAAAA
CGCAGAAATGGTAACACAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019734.1\|WP_014775587.1\|1247327_1247972_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_014775590.1\|1244100_1244571_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_141417777.1\|1256204_1256537_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273054
NZ_AP019734.1\|WP_141417773.1\|1249027_1249642_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200324
NZ_AP019734.1\|WP_117507374.1\|1263863_1265444_+\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|372283
NZ_AP019734.1\|WP_014775584.1\|1249646_1249970_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_141417774.1\|1251394_1252252_+\|DUF4138-domain-containing-protein	unknown	unknown	gnl\|CDD\|372643
NZ_AP019734.1\|WP_117507373.1\|1265453_1266371_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|374390
NZ_AP019734.1\|WP_022331671.1\|1258625_1259210_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_AP019734.1\|WP_141417771.1\|1244917_1247296_+\|DUF3875-domain-containing-protein	unknown	unknown	gnl\|CDD\|163495
NZ_AP019734.1\|WP_141417776.1\|1254393_1256142_-\|DNA-cytosine-methyltransferase	unknown	unknown	gnl\|CDD\|223348
NZ_AP019734.1\|WP_014775577.1\|1257346_1257598_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_055201579.1\|1260519_1263858_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019734.1\|WP_141417770.1\|1244572_1244914_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_117507372.1\|1267662_1269192_+\|DUF1735-domain-containing-protein	unknown	unknown	gnl\|CDD\|119359
NZ_AP019734.1\|WP_141418044.1\|1250344_1251367_+\|conjugative-transposon-protein-TraM	unknown	unknown	gnl\|CDD\|378868
NZ_AP019734.1\|WP_141417775.1\|1252391_1253285_-\|cell-filamentation-protein-Fic	unknown	unknown	gnl\|CDD\|376885
NZ_AP019734.1\|WP_141417772.1\|1247968_1249021_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_117507553.1\|1259412_1260363_+\|FecR-family-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP019734.1\|WP_022331666.1\|1266379_1267645_+\|DUF1735-domain-containing-protein	unknown	unknown	gnl\|CDD\|378016

Protein	Function_ID	Function_description	E-value
NZ_AP019734.1\|WP_141417777.1\|1256204_1256537_-\|hypothetical-protein	gnl\|CDD\|273054	TIGR00392, Isoleucine--tRNA_ligase, isoleucyl-tRNA synthetase. The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation].	0.00940637
NZ_AP019734.1\|WP_141417773.1\|1249027_1249642_+\|hypothetical-protein	gnl\|CDD\|200324	TIGR03781, Bac_Flav_CT_K, Bacteroides conjugative transposon TraK protein. Members of this protein family are designated TraK and are found in a proposed transfer region of a class of conjugative transposon found in the Bacteroides lineage. PSI-BLAST reveals a distant relationship to proteins TrbF and VirB8 in Proteobacterial conjugal transfer systems. [Cellular processes, DNA transformation].	5.64996e-06
NZ_AP019734.1\|WP_141418044.1\|1250344_1251367_+\|conjugative-transposon-protein-TraM	gnl\|CDD\|378868	pfam12508, Transposon_TraM, Conjugative transposon, TraM. Proteins in this entry are designated TraM and are found in a proposed transfer region of a class of conjugative transposon found in the Bacteroides lineage.	8.43625e-18
NZ_AP019734.1\|WP_141417774.1\|1251394_1252252_+\|DUF4138-domain-containing-protein	gnl\|CDD\|372643	pfam13595, DUF4138, Domain of unknown function (DUF4138). Based on Bacteroides thetaiotaomicron gene BT_4780, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture.	1.54765e-29
NZ_AP019734.1\|WP_117507373.1\|1265453_1266371_+\|hypothetical-protein	gnl\|CDD\|374390	pfam16141, DUF4849, Putative glycoside hydrolase Family 18, chitinase_18. This DUF is likely to be a form of glycosyl hydrolase from CAZy family 18, possibly chitinase 18. This would have the EC number of EC:3.2.1.14.	2.15577e-31
NZ_AP019734.1\|WP_141417771.1\|1244917_1247296_+\|DUF3875-domain-containing-protein	gnl\|CDD\|163495	TIGR03783, Bac_Flav_CT_G, Bacteroides conjugation system ATPase, TraG family. Members of this family include the predicted ATPase, TraG, encoded by transfer region genes of conjugative transposons of Bacteroides, such as CTnDOT, found on the main chromosome. Members also include TraG homologs borne on plasmids in Bacteroides. The protein family is related to the conjugative transfer system ATPase VirB4. [Cellular processes, DNA transformation].	5.85202e-58
NZ_AP019734.1\|WP_117507553.1\|1259412_1260363_+\|FecR-family-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	3.37476e-27
NZ_AP019734.1\|WP_055201579.1\|1260519_1263858_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019734.1\|WP_117507372.1\|1267662_1269192_+\|DUF1735-domain-containing-protein	gnl\|CDD\|119359	cd06542, GH18_EndoS-like, Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain. Some members also have an additional C-terminal glycosyl hydrolase family 20 (GH20) domain while others have an N-terminal domain of unknown function (pfam08522). Members of this family include endo-beta-N-acetylglucosaminidase S (EndoS) from Streptococcus pyogenes, EndoF1, EndoF2, EndoF3, and EndoH from Flavobacterium meningosepticum, and EndoE from Enterococcus faecalis. EndoS is a secreted endoglycosidase from Streptococcus pyogenes that specifically hydrolyzes the glycan on human IgG between two core N-acetylglucosamine residues. EndoE is a secreted endoglycosidase, encoded by the ndoE gene in Enterococcus faecalis, that hydrolyzes the glycan on human RNase B.	5.85031e-19
NZ_AP019734.1\|WP_117507374.1\|1263863_1265444_+\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	0
NZ_AP019734.1\|WP_141417775.1\|1252391_1253285_-\|cell-filamentation-protein-Fic	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	5.33949e-18
NZ_AP019734.1\|WP_022331671.1\|1258625_1259210_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	2.17585e-40
NZ_AP019734.1\|WP_141417776.1\|1254393_1256142_-\|DNA-cytosine-methyltransferase	gnl\|CDD\|223348	COG0270, Dcm, Site-specific DNA methylase [DNA replication, recombination, and repair].	2.78206e-30
NZ_AP019734.1\|WP_022331666.1\|1266379_1267645_+\|DUF1735-domain-containing-protein	gnl\|CDD\|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	4.21835e-24

>NZ_AP019734.1|WP_141417775.1|1252391_1253285_-|cell-filamentation-protein-Fic
MNYLSVSEISRRWDVSERTVRNWCAVGKIKGAFLTGKTWNIPEDAVRPRRGKEKPYSDNPLLNLLKEQKDMQLRGGIYHRVQIELTYNSNHIEGSRLTQEQTRHIFETNTLGVTDQAVNVDDVIETSNHFRCIDLVIDKAASGRLTEAFVKELHRILKAGTSDSRRTWFRVGEYKKFPNEVGGQETTPPEQVAAQMKALLSHYNTLTNKTLEDIVAFHHAFECIHPCQDGNGRVGRLIMFKECLANRVVPFIIDEDLKLFYYRGLHEWDRAHEYLLDTCRTAQDNFRAVMRYFKIEM
>NZ_AP019734.1|WP_141417774.1|1251394_1252252_+|DUF4138-domain-containing-protein
MKNYILAILFVCLATSGYGAKPEQIPLQQNKVCQIIFPDKIAKIRGGFNPNYFALDKYDNILYIQCLTNFPSTNLSIITEDTSCYMLDLCYTEKSEKNAYIIDIADRIYVNTPEPSEAGLKPSSPLRSQLDGDKIPAPATAHPETGEYESILKQRDFIVAQNGVADKAMEVFLKGIYTRDNYVYFKLDITNNSELPYTYNYCGFAIVTKKKGRMTSFDRTDLSPAGSYVPAHTIEYKKTMTVIYKFDKFNFSNDRVLLIEMVEDNGERGLFFRVTSSTFLKARKI
>NZ_AP019734.1|WP_141418044.1|1250344_1251367_+|conjugative-transposon-protein-TraM
MAVVLILIFGLIIRGVLSIQSNTSTDERMASEDIAFDIVAETPRTQGDTDEKLYQERLANSQSKTVPEDVKISFDAIFVPETPTGETPSPVAQSSQVPGTTTSYAPAAERNAMEKSAIQQELDAIYNSQSQNQPNATATDESQTEPSRPLTKDEILAQQKKLMEEGFNLSDLQDPMNTDSDAAVSIASPSEIPAFIHGPQTVMVGNRLALRIDTSVILSNGQVIPRNSIIYAQIALNNNRVQITVESIKFGAAIYSLELSGYSEDGSPGLPVQNDQNQKIVGDATSSAAASAIDRKISTVTGGLVGSVVRDISNAGRSRKETYVSFFDNQKVFLRPGLPK
>NZ_AP019734.1|WP_014775584.1|1249646_1249970_+|hypothetical-protein
MKRKIIVLLPILLFIPIFLWAAGGQDIAATTKLKGVIKDGVQIVAGLIALIAVIKIGLSTATKSILSGQEISQKETKDIITKLGYLIIGLSVMLFASSISDFITQKL
>NZ_AP019734.1|WP_141417773.1|1249027_1249642_+|hypothetical-protein
MKIFEHLTQLDNAVGFYRKGIIAILIVCAIFMTAMYIHTETRILQATSSAYILNQDGDVAIATRIRAAEFRKIEAEAHVRLFIMLFFDIDKYTYEQRISSTYALGNSSIYALKQRFDKDNWFTNMRQYNISQSVQITDLKCVAENPLAVDAIFTVTITSEVHSKPQIYEVSITFYLEETKERTKENPHALAITKIDFKNFNLKQ
>NZ_AP019734.1|WP_141417772.1|1247968_1249021_+|hypothetical-protein
MNPILTSGLANIINSFTTQFETYFNSNFLTLLSSEVGSYYGVLGAGLMFFLIVNGALFALREKTGKDLQTEIMRCVHLFLILIFGYCIIPAVDFFGETAIEYLYPNRQDAMQVAIDKSDGLGRIEASQYALSENDIRNVKRAQARVSKRNYNGAKIDNASDFNEDNKKESLWSLIKGGLVKLLANICLIVGAFCKLIITFFVLIIKALLRITFPVAVALSFIYGAEKTIGAWWQSYITVTMMSFIIAAIEILQNLLLFDVASNSLSVAQLGIALMAFAFGAAYLCAPTLTVLCVGGSEAAAQLPQQITTSFMTVGAMTWGILKSRSVTSGQFFKETYLKQKKGVSGRYFE
>NZ_AP019734.1|WP_014775587.1|1247327_1247972_+|hypothetical-protein
MKKILIIILAGVLLHPLPTKAQFGQDAAALIGFLTPYLGALEALSEASGMEISDLKKITQQSIQLTSSLAKVYNAGNRLYRVSSRTHEIYIEYLETIKYIYDNSIYFEDEEASYHVAVLNKVVFGQADQDGKLSVNNIMDGAMGDLKDLLNSMQSGAQTTLTEMARYLDDVRKQMDDTYGIICSYHTYLICSVNRKQHELGMYELDEYLTNRKK
>NZ_AP019734.1|WP_141417771.1|1244917_1247296_+|DUF3875-domain-containing-protein
MARTNLENIIPIYRIGDGYVIAKDGSVTVGFILTLPEYDTLSKADFRDDGSGDGMRLYTQLEAAIKDLDEGYTFHQQDIIYYAPQDLPHYDNYLSKTVNRMYNGKRWLSSKSYIFITKQKSISIQSDYSDEAIDKIVSVIKRFRAALSQFSPRRMDDKDWLEYLRDFFSMQGRCALDLSFQDQKFGNYKMAGIAVLADPHIKSLRDKVRNNATSSPYAQRFNALVSPLCWSVPCYKIINNIISREDPVAIRKHLKTFTRNIAFLGKAAASHIASAETMAEIIETGESLPVYHHFNAFLIYPENEETAIEDKLDIALEKMQIAPTRLSLDFEHIFMSSIGGCCSGLEFPLDMYPTFLDEVTVFSNLEADYAQARDGIVLNDTHGKPVVVDIFNETMRNSQISNRNFTAIGPSGSGKSVSANKLISGLVQTDEYFNFILDDGESYEMLHYLMGEKSGYMRMTPTGEELSFNPFLIPFVDPKNDSEKLLVPELEMLTSLILLLWDQNNGLGLKDDPGKTAYIKKLLYDFYSLRYEQRTEYVNFDSFYKYIIQQHKRGTLNDKYFDFDSFELVLHQYSKEGEWSLLLNSQNNSLNLAPQLRMCIVELKAVSNVKSIYKIVLYLIMLMARKVLAEAPTKYKIFWLDEAWKLLDDPYFGDFIKYLYKTIRKEDSGIGLIVQDVPDIIHSEHHEAIINNSDTMFFLSHEGKESNLEKYRSELSLTSRDLEIILSMKKSDHAICIRQGAHTTEYIVQLSQEELALYTTSKEHKATIKKYIDQYNGNVQMAINAYCHAQNK
>NZ_AP019734.1|WP_141417770.1|1244572_1244914_+|hypothetical-protein
MDTYIKYSFLIEIALIIIVLALLYIAVYFYRKKPVKSIPEMAVKEISPVEDEIISKLDRILAMIPVDYDSTLHSSDDDIKHDKRIIQQITGTEEEMTTILPQRDFNTRDLFEE
>NZ_AP019734.1|WP_014775590.1|1244100_1244571_+|hypothetical-protein
MASRRKYQSIQGLAESAELIVPEDPTEDQSAMGKEIASEPKPASIPEPMPKPERENQNDYESALDLQKIATQILIRQNYKNSRTAYPICEEYLHRIRAIAILGEIPITNVINNIFALFFNPDGPLNPTHTAIKSLLTDSNNMLKDYLISNRTTHRK
>NZ_AP019734.1|WP_141417776.1|1254393_1256142_-|DNA-cytosine-methyltransferase
MNSNDKIRLLYIDLFCGAGGTSTGVHLARHAGDPCAKVIACVNHDANAIASHAANHPDALHFTEDIRTLELGPLAAHAARMRRQYPDAFVVLWASLECTNFSRAKGGLPRDADSRTLAEHLFRYIEALNPDYIQIENVEEFMSWGDLDERGKPVSRDAGRLYRKWIDNVRGYGYDFGHRILNAADFGAYTSRRRFFGIFARRGLPIVFPKPTHTKNPAQGDLFGQQLGKWRPVREVLDLEDEGESIFDRKRPLVEASLARIHAGLVKFVAGGREAFLVKYNSMNQSGKYVAPGIDEPCPTVATQNRLGVAKVYYLCKHFGGSPEGKCTAVDAPAGAITCRDHHAFVSAYYGNGFNSSIERPSPTVTTKDRFQLVRPFFANYYSGGGQPEGTDGPAPAVMTNPKQRLVTPWIMNTNFSNVGSSLDAPAQTVTANRKWQYLMNPQFASAGAAADRPCFTLIARMDKRPPRLVTAEADGEELPSFIRLEDETLVYEIYPEDTPMLVQIKEFMALYGLVDIRMRMLRIPELMRIMGFPENYVLTGTQGEQKKFIGNAVEVNMARVLCEALVTKLYELNIVPQRLAA
>NZ_AP019734.1|WP_141417777.1|1256204_1256537_-|hypothetical-protein
MEISLDDYLGQRGLRSPISGYMDDKWRNMRLTARGQKRFEKEAEAAIIEYSKLRKAAIDEYNNLVKSGEIIPPHETKLEALLSVARGHPDNEGTQAARRLLKKRCGIISW
>NZ_AP019734.1|WP_014775577.1|1257346_1257598_-|hypothetical-protein
MENRAKKCIECGKTLTLDYFRRTPLSPDGYAKMCKLCANIKRTQGKNEERNPALLNFKARELIDELRARGYRGTLRITKDIQV
>NZ_AP019734.1|WP_022331671.1|1258625_1259210_+|RNA-polymerase-sigma-70-factor
MSELDKHITLEDFERLYSEYKPRFIIIARSYIRNNMAAEDIVTDSFLYFWENKDKLNITTTIQAYILGSVKHGCLEWLRNQKNRLKIQQQIHTTAYRSIKAKITVLESTNPEASFTAEIKSIIESQINKMPEPMRQIFLYNRFEGKTYQEIAEITGINVRNVTANIQRALAIMRIALNDYLIILIIVLYSSVIR
>NZ_AP019734.1|WP_117507553.1|1259412_1260363_+|FecR-family-protein
MDKELLYKYINGQTSEQEEKTIVDWLDADPNNQKELNALWSMQDALIANVPYPHHPHLQLPTRRLKWYRQRFIRICTQAAAVLLLVAGSWYASRTVIIEDTAKQYLSVAAPAGQRIDITLQDGTSVCLNSGAKLEYPIRFNRNRRVKLSGEAMFNVEHDAARPFIVETFACDVEVLGTKFNVTADELTHDFTTALLRGKVKVTNKLASGDQIILDPNEKVCLNGNRLVLTRIENTDDYLWTEGILNLVGHPFADIIAKMEKTYGVKIQIQTAELPQIDVIRGKIPVNMGLDYALRALQKITPFQYEKDENNVIHIK
>NZ_AP019734.1|WP_055201579.1|1260519_1263858_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MNNKFIQQIKCWFTFLFMICSTFSAWGAYAQTAKVTLQMDNVRMEQVMNEIEKQTSYFFIVNKGVDINRTISINVADKPLDTALQAMVAGTDTEYKIYQQNIYLSAAPDKKTANNGSTKVSGVVRDTKGTPVVGASVVVKGTTIGESSGLDGAFSLQVPAPVETAELYINFIGYDPVTVKIGTQTFFTITLNEAAEQIEDVVITALGIKRSEKALAYTVQQVKSEAVTTVKSANFVNSLAGKVAGAVINTSSSGVGGSAKVIMRGMKSIMQTSNVLYVIDGIPMHNFTSDGSMEFGSRGTTESIADMNPDDIESISVMTGAAAAALYGSDAANGAMLITTKKGKAGATQIQVSSNTEFMNPLRLPDFQTRYGTGRKGKASGSTIHSWGAPLNQAARYNYSPEDFLQTGHILTNSVTLSGGTEKNQIYFSTAAVNSKGLIPNNKYNRYNFTFRNTSNLLNDRLTLDVSGSYIIQKDRNMINQGVYSNPLVSAYLFPRGDDFSLVKAFERWNPARKIYEQFWPQGEGGDLRMQNPYWIAYRNPRENSRKRYMFTGGITYKITDWMNVAGRIRVDNTNSLYTEKLYATSNPTLLENSKKGKYTETRGEERQTYGDVMLNLSKTFKEKFSLDAHIGASIKDNRFDELSVYGPIAGAPNIFNVVNLDKSQKKTPKTGWHEQTQSFFYSLELGWKSQLFVTTTGRNDWASQLANSPQKSFFYPSVGVSWLPSSTFNFPEKFNYLKIRASWASVANPFPRELTIATHPYDDTISGWDDKSNYPIGQLYPERTKTWELGFDARFLHGFTLSASWYRADTYNQTFNPNLSASSGYSDIYIQTGHVRNTGVEASLGYDHQWKNWNWNSQFTFSWNKNKIIELCKEWYNPITEETITMNRLQISKLGRAKFILKEGGSMGDLYSTTDLRRDDKGNIEIDEGGNVVVEDNLPDMKLGSVFPDYNLAWRNSVSWKNLNLGFLVTARIGGIVNSLTQANMDLFGVSEATAAARDAGGALVNGRSLVNPETWYTAIASQGGIPQYYTYSATNVRLQELSLGYTIPRKWLHNICSITVSFVGRNLWMMYCKAPFDPEAVASTNNFYQGMDYFMMPSTRNLGFNINIKF
>NZ_AP019734.1|WP_117507374.1|1263863_1265444_+|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MNKIKTIIRAVALIAVVSASTGCLDNFEDYNRNPNEATDDELERDNYLVGSKLTKLQNMVIPSEEHLYQFVEALEGGSYGGYVEATVDSWETKFSTFNPTADWLKAPFVDVITETYPAYRGIINKTDDEVAVALANVLRVAIMNRLADAYGSIPYSKIVEDKKERLTVPYDTQQEAYTQMFKELDAALEALERNRDLSTEAFGEYDQVYNGDLKKWIKYANSLKLRMAMRLSYIDEQTAKAKAAEAIAAGVITENADNAKLQPELNRTALLWNSWQDHAIGADILCYMNGYKDPRRTKMFTQGTVGEGDAAVKGYYGLRIGTTPANKSKAVTACSSMLITDTDPILWMNAAEIAFLRSEYELRWGSAVSAQNFYEQGIRLSFEERGVAGAEDYIADEANVPEAYTDPLGVIENNTALPQSRITIKWKEDAQFEENLERIITQKWIAIFPLGNEAWAEYRRTGYPKLMPAKDNKSGGTVNSKYGMRRLPYPSEEYSENRTNVEAAITSLGGPDNGGTRTWWDCKPLN
>NZ_AP019734.1|WP_117507373.1|1265453_1266371_+|hypothetical-protein
MKQTIKYLILALLIPAAYCFTACDTDIEPIDQQIIKPDQQDPAQYAAYLAALKAYKASEHYIVYASLANAPAVPGSEKAFLRSLPDSLDIVALENAGNLTEYDIEDIPQAQAKGTKILYTVDYNTLAESTDAAALGTYLDKVIEDVNRYKFDGVTVRYGGAMDAAATQAAATIVSKLSSLTGKILMTEGNPLFIAKESHDAITYFVLTTTDAVNTFNIRSQLAYATDYAGIALEKIIITAEPGGKLTDENLVQQPAIAEAAKSVITMGPLAGLGIYNIGDDYYDAYINYKQTKHAIGLLNPANPK
>NZ_AP019734.1|WP_022331666.1|1266379_1267645_+|DUF1735-domain-containing-protein
MKLRRTYLYFVSAAFILLAGCESDYENRYPFDNAAYIDVAETSSDNNVTFKKTVTQLDRELSAVLISPAKENIEVTFGIDPSLAATYNAKHDTKYAVLDESYYEFPERTATVEAGKSVSEPLTIHFKNLDQLDIDATQLLPVTIVSAGGGLSTLSGSQTVYYLVRRSSAITTAAVLTDNWIDVPAFDKAGTADCVNGLTAVTYEAIVRVHDFHYAGPTSSYIEEKLSTIMGVEQHLLLRIGDTNFYADQLQVDGSGVSLGKFPEKNKGKLLSLEEWYHVAFTYDLETGIACIYVNGQLQSQTQVAPTVKVINLGLRAIDPDPETDARQFFIGYSYDAFRQLCGDISEVRIWSVARTQADIWRDMYDVENPAEKPELRAYWKFNEGSGNIIKDWSQYGNDAVAHTDLKWNTSVEIPQLNKQE
>NZ_AP019734.1|WP_117507372.1|1267662_1269192_+|DUF1735-domain-containing-protein
MKNMNKITGLLRTSALCLTLAAMAACDAEDFTRTAGDIPGKDDLANVGGVLRREKTPDQISALKLSEEQTTTDAVFYQLTQPAAADVTVTVDADATLVDEYNKDKQGDAKLTLFPLENVTFEGGKTLTVKRGEKTSPALTVTLSREGVEKGAYLLPLRATVANNDMSPSEKDQVIYYRILVGEIVPETQLDAYAFKIVGYVNTEEMNPLMGTKFYAETFDPDFNTITQTWIDIEVLRPAALKFDKTTRRAMLDIGPDLQYVLSNRDKYLMPLQKSSRKVLICITGGNTGLGFCNMTDEQITDFVFQLKYVVETYKLDGVNYFDIEASYGKDGMSGVNPASYAKLIKATKEALGDDKLVTVACDAESTDLLATAHDGIEAGKYIDYAWSGIFDKVVDAYADGAELKPIAGLEQSKYGGALLKTNNTQESAQLNPILTSLIKSLYRETQSGNVFAFWDMPTNSAGYEEGPKSAFNIVADAVTDWDWEYDGMILLINVTWDDRNYGNFTKDW

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Crispr_ID: NZ_AP019734_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019734_3

3066354-3066634

Orphan

Consensus_repeat	Method
ATTTTCGGAGAGATCGAGCGCAGTCAAT	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_AP019734_3

>merge|NZ_AP019734|3|3066354-3066634|CRISPRCasFinder
ATTTTCGGAGAGGTCGAGCTTCGCCAGGCTATTTCGGCTACAGTCCAATTTGGCCAATGCCCTATTTTCGGAGAGGTCGAGCCTTATTAACTTGTTTTTGCTGCAATCCAATACCTTCAGCTCCGTATTTTCGAAGAGGTCGAGTGTCGCTAATTCGTTTATGTTGCAGTACAATTCCGTCAATGCTTTGTTTTTGGAGAGATCGAGTGCTGCCAATCGGTTACATGTGCAATACAATACGTTCAACTCCGTATTTTGGGTCAGGTCGAGTTTTGTCAATT

>NZ_AP019734|3|2|3066354-3066634|CRISPRCasFinder
ATTTTCGGAGAGGTCGAGCTTCGCCAGG	CTATTTCGGCTACAGTCCAATTTGGCCAATGCCCT
ATTTTCGGAGAGGTCGAGCCTTATTAAC	TTGTTTTTGCTGCAATCCAATACCTTCAGCTCCGT
ATTTTCGAAGAGGTCGAGTGTCGCTAAT	TCGTTTATGTTGCAGTACAATTCCGTCAATGCTTT
GTTTTTGGAGAGATCGAGTGCTGCCAAT	CGGTTACATGTGCAATACAATACGTTCAACTCCGT
ATTTTGGGTCAGGTCGAGTTTTGTCAATT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019734.1\|WP_117508339.1\|3054815_3055385_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_117508334.1\|3062386_3063094_+\|DUF2807-domain-containing-protein	unknown	unknown	gnl\|CDD\|371327
NZ_AP019734.1\|WP_117508337.1\|3056245_3057316_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224410
NZ_AP019734.1\|WP_117508336.1\|3057319_3059134_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP019734.1\|WP_004289225.1\|3051600_3052494_-\|tyrosine-recombinase	unknown	unknown	gnl\|CDD\|271185
NZ_AP019734.1\|WP_117508323.1\|3078694_3079978_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271185
NZ_AP019734.1\|WP_117508328.1\|3070953_3071790_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319808
NZ_AP019734.1\|WP_117508326.1\|3073176_3074175_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_AP019734.1\|WP_117508335.1\|3059135_3062279_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224000
NZ_AP019734.1\|WP_141417969.1\|3052923_3053985_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271185
NZ_AP019734.1\|WP_117508333.1\|3063180_3066060_+\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NZ_AP019734.1\|WP_117508324.1\|3076921_3078448_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|235463
NZ_AP019734.1\|WP_117508338.1\|3055502_3056246_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_141417971.1\|3069457_3070867_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380191
NZ_AP019734.1\|WP_117508330.1\|3068210_3069461_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380191
NZ_AP019734.1\|WP_117508327.1\|3071796_3072213_-\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|225197
NZ_AP019734.1\|WP_117508325.1\|3074274_3076896_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NZ_AP019734.1\|WP_117508331.1\|3067108_3068176_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380191
NZ_AP019734.1\|WP_117508340.1\|3054326_3054803_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_AP019734.1\|WP_022331685.1\|3072224_3073175_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703

Protein	Function_ID	Function_description	E-value
NZ_AP019734.1\|WP_117508334.1\|3062386_3063094_+\|DUF2807-domain-containing-protein	gnl\|CDD\|371327	pfam10988, DUF2807, Putative auto-transporter adhesin, head GIN domain. This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In Structure 3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two. It seems likely that this family belongs to the superfamily of trimeric auto-transporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens. In the case of Parabacteroides distasonis, which is a component of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).	1.45864e-20
NZ_AP019734.1\|WP_117508337.1\|3056245_3057316_-\|hypothetical-protein	gnl\|CDD\|224410	COG1493, HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms].	0.000115606
NZ_AP019734.1\|WP_117508336.1\|3057319_3059134_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.10112e-73
NZ_AP019734.1\|WP_004289225.1\|3051600_3052494_-\|tyrosine-recombinase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.03409e-25
NZ_AP019734.1\|WP_117508323.1\|3078694_3079978_+\|site-specific-integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.71801e-23
NZ_AP019734.1\|WP_117508328.1\|3070953_3071790_-\|HAD-family-phosphatase	gnl\|CDD\|319808	cd07505, HAD_BPGM-like, beta-phosphoglucomutase-like family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. This family represents the beta-phosphoglucomutase-like family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. Family members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. It belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.09511e-14
NZ_AP019734.1\|WP_117508326.1\|3073176_3074175_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.98083e-44
NZ_AP019734.1\|WP_117508335.1\|3059135_3062279_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	3.00293e-56
NZ_AP019734.1\|WP_141417969.1\|3052923_3053985_-\|site-specific-integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.08553e-37
NZ_AP019734.1\|WP_117508333.1\|3063180_3066060_+\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	8.24494e-24
NZ_AP019734.1\|WP_117508324.1\|3076921_3078448_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|235463	PRK05434, PRK05434, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0
NZ_AP019734.1\|WP_141417971.1\|3069457_3070867_-\|hypothetical-protein	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.26327e-55
NZ_AP019734.1\|WP_117508330.1\|3068210_3069461_-\|hypothetical-protein	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.3289e-48
NZ_AP019734.1\|WP_117508327.1\|3071796_3072213_-\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|225197	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown].	7.04637e-20
NZ_AP019734.1\|WP_117508325.1\|3074274_3076896_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NZ_AP019734.1\|WP_117508331.1\|3067108_3068176_-\|hypothetical-protein	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	9.4496e-39
NZ_AP019734.1\|WP_117508340.1\|3054326_3054803_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.09604e-25
NZ_AP019734.1\|WP_022331685.1\|3072224_3073175_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	3.94886e-40

>NZ_AP019734.1|WP_117508333.1|3063180_3066060_+|PD-(D/E)XK-nuclease-family-protein
MKGFLEEVAADLYARYGEGLSDRAVLFPSRRARLFFVDALGRIAGRPMWQPEWVTIDDLTGEISGLHTGDRVRLITELYKVYSAYHNEPFDKFYFWGDMLLTDFDTIDKYLIDAQMLFRNISEIKEIEADISYLTPAQLRILSFWSSFGEQADLSEEKRRFLAIWKTLGPIYRRFRERLSSLGIAYNGMVQRAAADRIRGGGFAFPEPRRYVVAGFNALSECEKRLFGFLATAAETDFYWDYDSYYKDDPEQEAGMFVRSNVAQFPPRTELRHDNMRGEKQVVSVAAVSNAVQCKYAAAILAGLARRRREEDPGIAAGARPALGKETAVVLTDENLLLPLLYALPADIGRVNVTMGFPLRQSLAYTFVERLVELQNHRRRKGDGCTFYHADVAGILAHPYVAECDAALTRTMHEEIVRDRRISVDAAWLGRNELLKRIFTPAATWRELSDYMLDVVAAVARQPYEGDDARQRVEFLAVIAEQVTKLRNSLDECDIDLTAEVYTSLLRRHLQTLRIPFEGEPLEGIQIMGILETRNLDFENVIILSMNDDNFPGNHMAQASFIPYNLRAAYELPTPEHHEGVYAYYFYRLIQRAKTVHMLYCSHADDKSTGEPSRYIYQLDYESGFDVRKVEVGVDVNLAETAPIEVPKDEGVMARLERFVDAQSPATLSPTAFFRYVACPLRFYFHSIARLEADDEISEEVDAPMFGTILHAAVQTLYARIAGEAHPGETLRAMIRTGEVAQAVEAAINENYLQDKHATAEDYSGNLLLVKDIVIRYLRGGVMPYDAAHDAFSVSGLEEPVAYPFRFRAGGRDLEMKFAGIADRIDTLDDGALRVVDYKTGAPHLEFDGVESLFTGTGKQRLSNILQTLLYAMMLHRSRGCDVEPALYYVRNMNRPGYSPQLDDKQTGVKGARYTLYRERFEELLRAQLAELYDTSVPFRQCEDADTCKYCDFNVICKR
>NZ_AP019734.1|WP_117508334.1|3062386_3063094_+|DUF2807-domain-containing-protein
MKKMILSAVMLVFAASGRAQEAGAASPTEHNEWLTTFEAVAVDADLDIKFVKVPDTEAPKIVYDTKGSYTSKFRAEVKDKTLRISERPDSRRPDRTEVTVYYNTLQSVSLSGAAAVFEGTVDAVLLDLTLGRKASLTAAFDVKDLRMELTGGSSATLTGKAGYLTLFASTGRVAASGLEVMSAEVNAQSKADVSLWITDRFIGKTTTNARITYKGQPAVVRGGAKFMGGEISHVE
>NZ_AP019734.1|WP_117508335.1|3059135_3062279_-|UvrD-helicase-domain-containing-protein
MRARILNASAGSGKTYQLAYKYVRDVVEQPGIYRHILAVTFTNKATEEMKSRILKEIHLLASGQPSSYLDNLCRELSLDAATVRRRAREVRSKILHDYSRFTVLTIDTFFQRILRAFIKELGIDLNYNVEIETASVLTKSADTLIEQITTDRDLQRWLTDFVQERIDEGKKWDIRDGILTLGGELFKEKNKDALSAARPREELARIVGEATAHAAATKKRMQDAAAEAVRIIGDAGASVADFPYKGSGFAAYFYAVAGGSFERYGSRAEAACTRDEAWGKPGSTAQGLRPRLQPLLREMCGLYDENVRAWNTCDLLRENYRSFALLSDLYAKVQQMCDQENMMLLSETKYILSEFIGHNDAPFIYEKVGNRFEHFMIDEFQDTSVKEWENFLPLLQNAMAQSGATSVLIVGDIKQSIYRWRGGDWKILHSQAQQALGADSTELVNLTENYRSLPGVVDFNNKAIGRVVEADNRALNATLDEAAARGDMDARTAAGLRDTLQKAYREHAQTPRRLGGVPGYVSVETFAERPPVVERICEVLDKGFRPCDIMILVRGATDGAKVAAELLDFKRRNDDPRYRFDVMTQEALIVGNAPVSSFIAAALRLSLNPDDSLSRAVYNHYLGRGFDRPLPGDERTFFRSIRLLSPEEAFERIVMRHALHDDRQQTAYLQAIHEQIIGFCASKIADIALFLDWWEQQGQNRSLSVDESATTVEITTIHKAKGLEKRVVLIPWCSWQLDPKSGGNVTNIVWAEAQGDAGAVGRFPVKYKKAMAESGFSAEYYRELVYSHVDNINLLYVALTRAAESLHVFIPRKGGKSVGGLLLQSIGADGDKALLDGTEGRRTATEEGERFEFGLFTGPVPGGGKASDGRHVVLENYPTARADLRLRLPSQRYFEEEDEVELSPRNFGILMHKAFEQADDRQQIYEAVQRMRDDGTLSPAEAEALRGMVARALAHPVAGEWFGGGWQRVRNENEIIVPGAGSTRRPDRVMIRGTRAVVVDYKFGSREPGRYRRQVGEYLGLLRQMGYTKCEGYLWYVKLGEIEKVEG
>NZ_AP019734.1|WP_117508336.1|3057319_3059134_-|ABC-transporter-ATP-binding-protein
MNETIGIIPRAFRRRGVWVACTLLLRAGLNFLGLAMLLPVLALVLDPGSLEGGGMLARAYDGLGFASQRSFALAVCAAVVGVIVLKSLLGLWLARVERNYIFALYRTLSRRLLVTYHDRGLPFVKASNSAVLARNVNVVCLAFAAGVLKPAAAIAAEAMLLVLLFGALMWYTPLAALLALAVFLPSIWLYYGLVRNRINRYGELENKAQREKARLVAETFRGYADIEINNAFPMMLRQFDRAMDQVIRTRLRETAIGLLPQTFTEVGLAVGMALLVALSLGDGDGRAQMLFGVFAVAALRLMPSVRNIMTGWTAIKYNRYTIGILRDAAADCPPAPANPDCRDTPGPRSTPAATVAPGNSGNPGKPGNPGNPAADTASSPEKLPFRHEIAVRDLRFRFADGGCELFHGLSLTIRKGERIGIRGASGAGKTTLFNLLLGLYEPSGGEIAIDGTPLTAANRRAWQNRIGYVSQNLFIADGSFAANVALGIPAGEVDRERVMQALRAAQLGELVTGLAKGIDTHVGECGCRLSGGQRQRIGIARALYRQADVLFFDEATSALDSRTEEEINRSIAGLAARDAGLTLVVIAHRESSLEYCNRIITIGE
>NZ_AP019734.1|WP_117508337.1|3056245_3057316_-|hypothetical-protein
MEYLIAGIRIDIPHRFTTGAFGMALAPFAAGSKTETDAGSNRMAGPVPGTATTAAPSPSETPGTERSAPHPATSPADTAQPDLILHTRLLAGDTAGYRELDAFDFTDADADCRFGRDTEGYLLTMTPRDGSAPARFHKAFGSPDATSDITPEHNPALFRFGLWTMFNIAALERRAVAVHSSVISLDGRAVLFLGESGTGKSTHTRLWREHIPGARLLNDDSPIIRIAPERAAEAASAPAADTIPALQGVLACGSPWSGKTPCYRNVSHPIAGIVRLSQAPQNRIRRLRPIEAIGALLPSCPPSFAHDERLEDAICRLVSQIVAQVPVYHLECLPDAAAARLSCRTVFGDDAPNTLR
>NZ_AP019734.1|WP_117508338.1|3055502_3056246_-|hypothetical-protein
MLLTNRLFFEQVEAMLAEGHEVQIRMKGHSMRPLLRNERDIAVLTPIAKYAPAPVPAAGASADPVPETRAADGNASTARQTRLSGNTPGMAPDQLTPACGTRHPAPPPSGISALRPGDVVLFRCEGRHILHRIVGIETGIRCEGNRPVCAPAAGNAPSPAASAENPAERDSAAGTLRFTLSGDGNYRTTEHCLGKDIVAVMTAVILPSGRIVRTSSRRWKRRSRRWLALPRGVRRFVLRVMWRFGIR
>NZ_AP019734.1|WP_117508339.1|3054815_3055385_+|hypothetical-protein
MELEELKLKWKVLSERLDREQVIRRQDMERMLRGRVGSYLHYVQLMLLLGVAVVPLCVAIGKFRGVSDIFIWWVVAGYLLCLLPSFFSLWLLLRVSRCDADIVECEHRMTRYAAFAGAYYIFQYVVVILFVAGMLLYAAGYYTAHGMWWTVAALLSLTAVACIVITRHEWGRIRDLQRRIRELREFDEA
>NZ_AP019734.1|WP_117508340.1|3054326_3054803_+|sigma-70-family-RNA-polymerase-sigma-factor
MDTEQRFIELIEHHKRIIYKVCYVYAPGRGQIDDYFQEVVLALWRGFPDFRGESKTATWVYRIALYTCISFVRRRMRRPQSVRLSVDLACDDDMQAREQLDELYAVISRLGRLDRALILLWLEEHPAGEIAAITGLSPGNVAVKLTRIRCKLRKMYNR
>NZ_AP019734.1|WP_141417969.1|3052923_3053985_-|site-specific-integrase
MRSTFKVLFYLKRNKDKDQKVVPVMGRITVNGSIAQFSAKLSVPEMLWEVSGGRAKGRSLEADRINRHLDNIRTQIGKHYQDICDRESYVTAEKVKNAYLGFGEKYRLLLEAFEKFTGDLKKRVGIDRCHGTWNRYYKSIDHLRTFMRKEYNVSDMPLAELEQSFIEQYHVYLKSDLGLKPTTVSGYLKCLKYVVKIAFNNGWMPRNPFSLYQYTAPNPERSFLTEDELRRMMTTELRYKRQDYNRDMFLFSCFTGICYADMASLTYDRIEQDAQGEWWISGNRQKTETRYVVKLLPYALFILNKYRGLTGDGRVFAMSTLDSIDDSLKNIARECGIDKQLSFHMAKHHTISI
>NZ_AP019734.1|WP_004289225.1|3051600_3052494_-|tyrosine-recombinase
MGRITINGTQAGFSCKKEVSLALWDVKTNRAKGKSEEARTLNQELDNIKAQITRHYQYICDHDSFVTAKKVYNRYVGFSEECHTLMNLFREQLEPYKKKIGIEKAESTYCGLVADYKSLLLFMKSKKNAEDIVIEELEKSFIEDYYNWMLGTCALANSTVFGRVNTLKWLMYIAQEKGWIRVHPFASFECMPEYKRRSFLSEEELQRIIHIEPRYKRQRAMRDMFLFMCFTGLSYVDLKAITYDNIHTDSDGGTWLMGNRIKTGVAYVVKLLPIAIELIEKYRGTDEKKDSPNVSFR
>NZ_AP019734.1|WP_117508331.1|3067108_3068176_-|hypothetical-protein
MKRFLPITALAVFAYPAATISCQNGQGAANPQIFWDGGAIPDPVFRTYVLENFDTDRDGKISRKEADAVLAIDLGRLCGESSDTPAIESLAGVEHFRNLKQLICNGHALTELDLSKNTELNILKCKDNQLTTLDLSENTALLTLNCGRNPIKTLDLTENRALSMLVCDYNQLTVFDLSQNTALTQLFCGHNQLTALDLSENTMLTDLWCDYNRLTELDLSKNTELTDLSCGWNPITALDLSENTKLTYLNCLNNQLTALDLSENAALTELYCGYNRLTALDLSENTELIRLGCSDNPLIRLNLSDLAKLEAVSFDYENHEIQVITNSQTAFVSDLTRYMQSIEAEKQKKYRQQEE
>NZ_AP019734.1|WP_117508330.1|3068210_3069461_-|hypothetical-protein
MNRLLPVIALAVLAYPAAPVSGQSGEENAKPPIFWDGGMIPDPGFRAYVLENFDTDRDGKISSEEADAVLVIDLGREEPTDTPGIKSLEGVEYFKNLRELIGAFHPLTSLRLSENMALTKLNCRDSQLTALDLSKNKALTLLDCAYNQLTALDLADNTALIGLDCSGNQLSVLDLTQNPELTGLNCSHNRLTALDLTGNPALTQLDCRDNRLTSLDLTGNPALTQLDCRDNRLTALDLAQNTALIRLDCHNNRLTALNLTGNPMLTELVCSYNLLPTLDLSENTMLTDLWCESNRLTSIDLSQNKALSRLYCDNNRLTTLDLSANTALTGLSCHDNRLTALALSKNTKLVALGCCDNPLIRLNLSDLAKLGAISLDYDNYKIQVITNSRTAIVSSLTRYMQSIEAEKQKKHLQQEE
>NZ_AP019734.1|WP_141417971.1|3069457_3070867_-|hypothetical-protein
MKRFLPITVLAVFAYPAATISCQSGKKAADPQIFWDGGAIPDPVFRTYVLDNFDTDRDGKISRKEADAVLAIDLGRLCAELGPATESLAGIEYFKNLKQLICNGNTLAELDLSQNTRLTELNCWDNPLPALNLSKNTELVKLNCNYTALAELDLTQNTALTELACEGNPLTSLDLSKNTKLTVLFCPANQLTALDLSKNTALKELLCYSNRLTGLDLTQNKELVHLHCYYNQLTSLDLSQNTALEELLCYENQLTALDLSKNAALIQLNCYNNRLRALDLSENTALTKLFCGYNPLTELDVSRNTKLTELLCHENQLTALDLTHNTALATVYCPNNRLTALDLSKNTALATLACSRNQLTALDLSQNTAITELYCNNNQLAALDLSRNTALTELYCNGNRLTTLDLSRNTELTKIYCDDNPLTELNISNLSKIEEIVFGDNPEINVIANSQTVVSDEVRHYMDGKRKTP
>NZ_AP019734.1|WP_117508328.1|3070953_3071790_-|HAD-family-phosphatase
MQIRLILLDFDGTLADTRRANTLAYVATLREAGYTLTEEEYAAKYFGMRCNEFLTRYGIADPAERERLRLRKIALYPAFFDTVRLNRPLWEFCRQFRAQGGRVWIVSTGSRANIDNAMRHLGITVAGQLTGSTAPAGCAGMDEAGMVGAGKGTTATGMDGAGVEGTGKGTAGADVDTTGAGNTAPGAAGSYTATAGTGAATPGAAWDPAPGEGPNGSVDGILSGTDVEHSKPAPDCFLEAMRREGCTPQETLIFEDSEIGLEAARRSGASYFVVKLDT
>NZ_AP019734.1|WP_117508327.1|3071796_3072213_-|MmcQ/YjbR-family-DNA-binding-protein
MGNDWTKDFGFAREEIFRSEETLRTIRHIRASWGCEPEFLWEKFPDYAVFRRQDNAKWYAVILTVQAGKLGLADEGRTEILDIRADAETMARALDFEHYFPGYHMNKRTWLTVRLDGSVPFGEIAPLIARSYELAGKK
>NZ_AP019734.1|WP_022331685.1|3072224_3073175_-|M23-family-metallopeptidase
MAGKKDLERLRRRKRRKQNIIRATVHFFVWAGVAVLYYIGFSLFFDTPVEYELKHSTDRLRREYAALTQRYDSLTTVMHNLSERDRNVFRILFESDPYDFDSEYERRQAVTYENIFNRSSRRLKLELRERVADMEKRLDELNASYLDLQALIDSAGSGCNNIPAIQPVINKQLTLLTASYGMRIHPFYKTLQSHQGVDYTIPEGSRVFATADGVVRDVALRNSTSGQTVVIDHGNGYETSYSHLSKINVRKGQRVSRGEIIALSGDTGLSLSPHLHYEVRLNGMRVDPIHYFFMELTPTEYQRLMRIAQSGMQSFD
>NZ_AP019734.1|WP_117508326.1|3073176_3074175_-|M23-family-metallopeptidase
MKQKGQRFDTQALTQEAQALTRDVVTAPFRLRTYRLIRKILIGFILVSIANVLFSYFFYTPKMYRIIRDNRDLVIKYRILQDRIRTSQRRVDEIRHRDNYVYRSLFSTDTVSIDGVWQPYPDTKYAAMAGDDFAPLMVGTWKQLDALARILYLESVSFDELQAFARDKEKMSAAIPAIWPIDRSALHNDHIGAFNLRRMHPVLGYIRPHKGIDLGCDRGTPVYATGDAVVEVASSGGNGGYGHMVLLNHEFGYKTRYAHLSKVLVQPGERVARGQVIAETGNTGISSGPHLHYEVIHKGMPVNPINYFNRNMTAAEYDALMENMRDTNFEKL
>NZ_AP019734.1|WP_117508325.1|3074274_3076896_+|alanine--tRNA-ligase
MESNKIRRAFLDFFESKGHVIVPSAPMVVKGDPTLMFTNAGMNQFKDIFLGNAPRKYPRAADTQKCLRVSGKHNDLEEVGHDTYHHTMFEMLGNWSYGDYFKKEAIEWAWELLHGVYKLPADRMYATVFEGSEEDGVPFDQEAYDYWKQFLPEDHIIRGNKHDNFWEMGETGPCGPCSEIHFDLRDEAEIAAEPGRGMVNEGHPQVIEIWNLVFMQFNRKANGSLEELPARNVDTGMGFERLCMILQGKKSNYDTDVFQPTIQRISQLSGKTYGADAKCDVAMRVIADHLRAIAFSIADGQLPSNVKAGYVIRRILRRAVRYGYTYLGFTEPTICKLVAGLVEQMGGQFPELKAQQALIEKVIEEEEASFLRTLATGISLLDGVVEKTKKEGRELISGKNAFELYDTFGFPIDLTELIAREQGVGVDLAAFETELQAQKERSRNAAAVDTDDWVELFPIRESVFTGYDTLTERVKIARYRRVTSKGKTSYQLVFDRTPFYGNSGGQIGDIGYIENANERIAVVATEKENGLIIHIVKELPENPAAEFTAVVDAAKRQAAANNHTATHLMHEALRKVLGSHVEQKGSMVTPEILRFDFSHFQKMTPAELRQVEMLVNRAVRANYPLEENREATKEEAEKCGAMMLFGEKYGDRVRMVRFGTSVELCGGTHTSATGNIGFFKILTESAISAGVRRIEAVTGEQAEKIIYAAEDTMRDISEYLHNPQVLQAVKKMFESNETLSKEVEAMRREQVAQWAEKIISSTPERHGVQLIATQTDRTPEFVKDLAYNLRARSPKLVFVQGAVNDGKPMLTVMLGDEITAQGVNAGAVVREAAKLMQGGGGGQAFFATAGGKNPDGLQAAIDKAVELIMAQVK
>NZ_AP019734.1|WP_117508324.1|3076921_3078448_+|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MNNKVLLMILDGWGNGRHDKADVISTVHPEYISAMTAKYPHAELRTDGGNVGLPDGQMGNSEVGHLNIGAGRVVYQDLVKINRACRDNSILENPEVKAAFEHAKKNGVNMHFMGLVSDGGVHSSLEHLFKLCDISAAYGLENTFVHCFMDGRDTDPHSGKGFVADLEKHLAATTGKIATVIGRYYAMDRDKRWERVKVAYDALVSGIGERSSDMVEAVQKSYDEGVTDEFIKPFVRIDENGQPVGMIRPNDVVVFFNYRNDRAKELTIVLTQEDMPAEGMHTLPLYYCCMTPYDAKFTGLHILFDKENVPNTIGEFVSKQGLRQLRIAETEKYAHVTFFLNGGREAEFAGEDRILVASPKVATYDLQPEMSAPEVADKLVAALGERKFDFICLNFANGDMVGHTGVYDAIVKAVKAVDGCVAKVVEAAKENGYEVVMIADHGNADNAVNADGTPNTAHSLNPVPIVVVSDRVKSVHDGILADVAPTVLRLMGLEQPAEMTGKALVEMK
>NZ_AP019734.1|WP_117508323.1|3078694_3079978_+|site-specific-integrase
MFSIKVKGKPNPKNSNLVKLELVFFQTDYPRVTKVLDITGQYKDWDERSQTFRNGSPDAYSKNRSLSEVCMRYQRVAEEWTVSGLFWSPVELSHCFDRQQSAVRQDIRIWTVSQLIDERITYFDSKDRIKNGQIILSSSNARKYEKFHRSLKAFVSAVYGKSLSSYFFKDIDAKFLTDYAFYLKRRGAENGNQGCLVSHLRLLRALCNYAAKLGMPGAGITAFDSLGDMIKWPETTSRAVSAKTIALLENIDRSLFSAKEQLHLDLFRFSYYTGGMANVDVCNLTWDCVQEDKIVYERIKFPKTAKPLLTPPQSRALLRKYKGTGSGNYVFPVFTRKHTDSVKRYTRVHQISNLVTRTLTKACRILKIKEHVTWYSARGSFISRMVDDGNSPYAVAEMAGNSPMTIWKNYYKNTEREKLAERTRAVL

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Crispr_ID: NZ_AP019734_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019734_4

3067322-3067664

Orphan

Consensus_repeat	Method
ATTTTCGGAGAGATCGAGCGCAGTCAAT	CRISPRCasFinder

5 spacers

The CRISPR arrays of NZ_AP019734_4

>merge|NZ_AP019734|4|3067322-3067664|CRISPRCasFinder
ATTTTCGGAGAGATCGAGCGCAGTCAATCGATTGTAGCCGCAGTATAATTCGGTCAGCGCTGCATTTTCGGAGAGATCGAGCGCGGTCAATTGATTGTTGAGGCAATTCAAATAAGTTAACTTTGTATTTTCGGAGAGATCGAGTGCTGTTATCGGATTCCAACCGCAGGACAAATCGGTCAACTCCGTATTTTTGGAAAGATCGAGTTCCGTCAATCGATTGTAATCGCACCACAAGTCGGTAAGCATCGTATTTTCGGATAGATCGAGCGCAGTCAATTGATTGTGCCCGCAGAACAATTGCGTCAGGGCTGTATTTTGGGAGAGATCGAATACGGTCAAT

>NZ_AP019734|4|3|3067322-3067664|CRISPRCasFinder
ATTTTCGGAGAGATCGAGCGCAGTCAAT	CGATTGTAGCCGCAGTATAATTCGGTCAGCGCTGC
ATTTTCGGAGAGATCGAGCGCGGTCAAT	TGATTGTTGAGGCAATTCAAATAAGTTAACTTTGT
ATTTTCGGAGAGATCGAGTGCTGTTATC	GGATTCCAACCGCAGGACAAATCGGTCAACTCCGT
ATTTTTGGAAAGATCGAGTTCCGTCAAT	CGATTGTAATCGCACCACAAGTCGGTAAGCATCGT
ATTTTCGGATAGATCGAGCGCAGTCAAT	TGATTGTGCCCGCAGAACAATTGCGTCAGGGCTGT
ATTTTGGGAGAGATCGAATACGGTCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019734.1\|WP_117508339.1\|3054815_3055385_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_117508334.1\|3062386_3063094_+\|DUF2807-domain-containing-protein	unknown	unknown	gnl\|CDD\|371327
NZ_AP019734.1\|WP_117508337.1\|3056245_3057316_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224410
NZ_AP019734.1\|WP_117508336.1\|3057319_3059134_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP019734.1\|WP_117508323.1\|3078694_3079978_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271185
NZ_AP019734.1\|WP_141417970.1\|3066155_3066929_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380191
NZ_AP019734.1\|WP_117508326.1\|3073176_3074175_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_AP019734.1\|WP_117508335.1\|3059135_3062279_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|224000
NZ_AP019734.1\|WP_141417972.1\|3080179_3080662_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_117508328.1\|3070953_3071790_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319808
NZ_AP019734.1\|WP_141417969.1\|3052923_3053985_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271185
NZ_AP019734.1\|WP_117508333.1\|3063180_3066060_+\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NZ_AP019734.1\|WP_117508324.1\|3076921_3078448_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|235463
NZ_AP019734.1\|WP_117508338.1\|3055502_3056246_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019734.1\|WP_141417971.1\|3069457_3070867_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380191
NZ_AP019734.1\|WP_117508330.1\|3068210_3069461_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380191
NZ_AP019734.1\|WP_117508327.1\|3071796_3072213_-\|MmcQ/YjbR-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|225197
NZ_AP019734.1\|WP_117508325.1\|3074274_3076896_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
NZ_AP019734.1\|WP_117508340.1\|3054326_3054803_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_AP019734.1\|WP_022331685.1\|3072224_3073175_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703

Protein	Function_ID	Function_description	E-value
NZ_AP019734.1\|WP_117508334.1\|3062386_3063094_+\|DUF2807-domain-containing-protein	gnl\|CDD\|371327	pfam10988, DUF2807, Putative auto-transporter adhesin, head GIN domain. This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In Structure 3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two. It seems likely that this family belongs to the superfamily of trimeric auto-transporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens. In the case of Parabacteroides distasonis, which is a component of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).	1.45864e-20
NZ_AP019734.1\|WP_117508337.1\|3056245_3057316_-\|hypothetical-protein	gnl\|CDD\|224410	COG1493, HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms].	0.000115606
NZ_AP019734.1\|WP_117508336.1\|3057319_3059134_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.10112e-73
NZ_AP019734.1\|WP_117508323.1\|3078694_3079978_+\|site-specific-integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.71801e-23
NZ_AP019734.1\|WP_141417970.1\|3066155_3066929_-\|hypothetical-protein	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.58509e-37
NZ_AP019734.1\|WP_117508326.1\|3073176_3074175_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.98083e-44
NZ_AP019734.1\|WP_117508335.1\|3059135_3062279_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	3.00293e-56
NZ_AP019734.1\|WP_117508328.1\|3070953_3071790_-\|HAD-family-phosphatase	gnl\|CDD\|319808	cd07505, HAD_BPGM-like, beta-phosphoglucomutase-like family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. This family represents the beta-phosphoglucomutase-like family of the haloacid dehalogenase-like (HAD) hydrolase superfamily. Family members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), Saccharomyces cerevisiae phosphatases GPP1 and GPP2 that dephosphorylate DL-glycerol-3-phosphate and DOG1 and DOG2 that dephosphorylate 2-deoxyglucose-6-phosphate, and Escherichia coli 6-phosphogluconate phosphatase YieH. It belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.09511e-14
NZ_AP019734.1\|WP_141417969.1\|3052923_3053985_-\|site-specific-integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.08553e-37
NZ_AP019734.1\|WP_117508333.1\|3063180_3066060_+\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	8.24494e-24
NZ_AP019734.1\|WP_117508324.1\|3076921_3078448_+\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|235463	PRK05434, PRK05434, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0
NZ_AP019734.1\|WP_141417971.1\|3069457_3070867_-\|hypothetical-protein	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.26327e-55
NZ_AP019734.1\|WP_117508330.1\|3068210_3069461_-\|hypothetical-protein	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	1.3289e-48
NZ_AP019734.1\|WP_117508327.1\|3071796_3072213_-\|MmcQ/YjbR-family-DNA-binding-protein	gnl\|CDD\|225197	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown].	7.04637e-20
NZ_AP019734.1\|WP_117508325.1\|3074274_3076896_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
NZ_AP019734.1\|WP_117508340.1\|3054326_3054803_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.09604e-25
NZ_AP019734.1\|WP_022331685.1\|3072224_3073175_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	3.94886e-40

>NZ_AP019734.1|WP_141417970.1|3066155_3066929_-|hypothetical-protein
MLGRFDTDRNGKISREEADAVFAIDVDAETADTPLIESLTGVEYFKNLGKLTCNWNNLAALDLSENTALDTLDCSWNRIKALDLAGNKALAKLDCSQNQLTKLDLTQNTELNVLYCTCNRLAALDLSKNKALTELYCNINELATLDLFENTELKVLDCSKNKLIRLDLSENRALAKLDCSRNSLAKLDLSENTALHFLSAWQNPLLLLDISGLSKIRHMDFDFEDNDIQVITDHRTAIDDDLLRYYAIRRSRKAEKE
>NZ_AP019734.1|WP_117508333.1|3063180_3066060_+|PD-(D/E)XK-nuclease-family-protein
MKGFLEEVAADLYARYGEGLSDRAVLFPSRRARLFFVDALGRIAGRPMWQPEWVTIDDLTGEISGLHTGDRVRLITELYKVYSAYHNEPFDKFYFWGDMLLTDFDTIDKYLIDAQMLFRNISEIKEIEADISYLTPAQLRILSFWSSFGEQADLSEEKRRFLAIWKTLGPIYRRFRERLSSLGIAYNGMVQRAAADRIRGGGFAFPEPRRYVVAGFNALSECEKRLFGFLATAAETDFYWDYDSYYKDDPEQEAGMFVRSNVAQFPPRTELRHDNMRGEKQVVSVAAVSNAVQCKYAAAILAGLARRRREEDPGIAAGARPALGKETAVVLTDENLLLPLLYALPADIGRVNVTMGFPLRQSLAYTFVERLVELQNHRRRKGDGCTFYHADVAGILAHPYVAECDAALTRTMHEEIVRDRRISVDAAWLGRNELLKRIFTPAATWRELSDYMLDVVAAVARQPYEGDDARQRVEFLAVIAEQVTKLRNSLDECDIDLTAEVYTSLLRRHLQTLRIPFEGEPLEGIQIMGILETRNLDFENVIILSMNDDNFPGNHMAQASFIPYNLRAAYELPTPEHHEGVYAYYFYRLIQRAKTVHMLYCSHADDKSTGEPSRYIYQLDYESGFDVRKVEVGVDVNLAETAPIEVPKDEGVMARLERFVDAQSPATLSPTAFFRYVACPLRFYFHSIARLEADDEISEEVDAPMFGTILHAAVQTLYARIAGEAHPGETLRAMIRTGEVAQAVEAAINENYLQDKHATAEDYSGNLLLVKDIVIRYLRGGVMPYDAAHDAFSVSGLEEPVAYPFRFRAGGRDLEMKFAGIADRIDTLDDGALRVVDYKTGAPHLEFDGVESLFTGTGKQRLSNILQTLLYAMMLHRSRGCDVEPALYYVRNMNRPGYSPQLDDKQTGVKGARYTLYRERFEELLRAQLAELYDTSVPFRQCEDADTCKYCDFNVICKR
>NZ_AP019734.1|WP_117508334.1|3062386_3063094_+|DUF2807-domain-containing-protein
MKKMILSAVMLVFAASGRAQEAGAASPTEHNEWLTTFEAVAVDADLDIKFVKVPDTEAPKIVYDTKGSYTSKFRAEVKDKTLRISERPDSRRPDRTEVTVYYNTLQSVSLSGAAAVFEGTVDAVLLDLTLGRKASLTAAFDVKDLRMELTGGSSATLTGKAGYLTLFASTGRVAASGLEVMSAEVNAQSKADVSLWITDRFIGKTTTNARITYKGQPAVVRGGAKFMGGEISHVE
>NZ_AP019734.1|WP_117508335.1|3059135_3062279_-|UvrD-helicase-domain-containing-protein
MRARILNASAGSGKTYQLAYKYVRDVVEQPGIYRHILAVTFTNKATEEMKSRILKEIHLLASGQPSSYLDNLCRELSLDAATVRRRAREVRSKILHDYSRFTVLTIDTFFQRILRAFIKELGIDLNYNVEIETASVLTKSADTLIEQITTDRDLQRWLTDFVQERIDEGKKWDIRDGILTLGGELFKEKNKDALSAARPREELARIVGEATAHAAATKKRMQDAAAEAVRIIGDAGASVADFPYKGSGFAAYFYAVAGGSFERYGSRAEAACTRDEAWGKPGSTAQGLRPRLQPLLREMCGLYDENVRAWNTCDLLRENYRSFALLSDLYAKVQQMCDQENMMLLSETKYILSEFIGHNDAPFIYEKVGNRFEHFMIDEFQDTSVKEWENFLPLLQNAMAQSGATSVLIVGDIKQSIYRWRGGDWKILHSQAQQALGADSTELVNLTENYRSLPGVVDFNNKAIGRVVEADNRALNATLDEAAARGDMDARTAAGLRDTLQKAYREHAQTPRRLGGVPGYVSVETFAERPPVVERICEVLDKGFRPCDIMILVRGATDGAKVAAELLDFKRRNDDPRYRFDVMTQEALIVGNAPVSSFIAAALRLSLNPDDSLSRAVYNHYLGRGFDRPLPGDERTFFRSIRLLSPEEAFERIVMRHALHDDRQQTAYLQAIHEQIIGFCASKIADIALFLDWWEQQGQNRSLSVDESATTVEITTIHKAKGLEKRVVLIPWCSWQLDPKSGGNVTNIVWAEAQGDAGAVGRFPVKYKKAMAESGFSAEYYRELVYSHVDNINLLYVALTRAAESLHVFIPRKGGKSVGGLLLQSIGADGDKALLDGTEGRRTATEEGERFEFGLFTGPVPGGGKASDGRHVVLENYPTARADLRLRLPSQRYFEEEDEVELSPRNFGILMHKAFEQADDRQQIYEAVQRMRDDGTLSPAEAEALRGMVARALAHPVAGEWFGGGWQRVRNENEIIVPGAGSTRRPDRVMIRGTRAVVVDYKFGSREPGRYRRQVGEYLGLLRQMGYTKCEGYLWYVKLGEIEKVEG
>NZ_AP019734.1|WP_117508336.1|3057319_3059134_-|ABC-transporter-ATP-binding-protein
MNETIGIIPRAFRRRGVWVACTLLLRAGLNFLGLAMLLPVLALVLDPGSLEGGGMLARAYDGLGFASQRSFALAVCAAVVGVIVLKSLLGLWLARVERNYIFALYRTLSRRLLVTYHDRGLPFVKASNSAVLARNVNVVCLAFAAGVLKPAAAIAAEAMLLVLLFGALMWYTPLAALLALAVFLPSIWLYYGLVRNRINRYGELENKAQREKARLVAETFRGYADIEINNAFPMMLRQFDRAMDQVIRTRLRETAIGLLPQTFTEVGLAVGMALLVALSLGDGDGRAQMLFGVFAVAALRLMPSVRNIMTGWTAIKYNRYTIGILRDAAADCPPAPANPDCRDTPGPRSTPAATVAPGNSGNPGKPGNPGNPAADTASSPEKLPFRHEIAVRDLRFRFADGGCELFHGLSLTIRKGERIGIRGASGAGKTTLFNLLLGLYEPSGGEIAIDGTPLTAANRRAWQNRIGYVSQNLFIADGSFAANVALGIPAGEVDRERVMQALRAAQLGELVTGLAKGIDTHVGECGCRLSGGQRQRIGIARALYRQADVLFFDEATSALDSRTEEEINRSIAGLAARDAGLTLVVIAHRESSLEYCNRIITIGE
>NZ_AP019734.1|WP_117508337.1|3056245_3057316_-|hypothetical-protein
MEYLIAGIRIDIPHRFTTGAFGMALAPFAAGSKTETDAGSNRMAGPVPGTATTAAPSPSETPGTERSAPHPATSPADTAQPDLILHTRLLAGDTAGYRELDAFDFTDADADCRFGRDTEGYLLTMTPRDGSAPARFHKAFGSPDATSDITPEHNPALFRFGLWTMFNIAALERRAVAVHSSVISLDGRAVLFLGESGTGKSTHTRLWREHIPGARLLNDDSPIIRIAPERAAEAASAPAADTIPALQGVLACGSPWSGKTPCYRNVSHPIAGIVRLSQAPQNRIRRLRPIEAIGALLPSCPPSFAHDERLEDAICRLVSQIVAQVPVYHLECLPDAAAARLSCRTVFGDDAPNTLR
>NZ_AP019734.1|WP_117508338.1|3055502_3056246_-|hypothetical-protein
MLLTNRLFFEQVEAMLAEGHEVQIRMKGHSMRPLLRNERDIAVLTPIAKYAPAPVPAAGASADPVPETRAADGNASTARQTRLSGNTPGMAPDQLTPACGTRHPAPPPSGISALRPGDVVLFRCEGRHILHRIVGIETGIRCEGNRPVCAPAAGNAPSPAASAENPAERDSAAGTLRFTLSGDGNYRTTEHCLGKDIVAVMTAVILPSGRIVRTSSRRWKRRSRRWLALPRGVRRFVLRVMWRFGIR
>NZ_AP019734.1|WP_117508339.1|3054815_3055385_+|hypothetical-protein
MELEELKLKWKVLSERLDREQVIRRQDMERMLRGRVGSYLHYVQLMLLLGVAVVPLCVAIGKFRGVSDIFIWWVVAGYLLCLLPSFFSLWLLLRVSRCDADIVECEHRMTRYAAFAGAYYIFQYVVVILFVAGMLLYAAGYYTAHGMWWTVAALLSLTAVACIVITRHEWGRIRDLQRRIRELREFDEA
>NZ_AP019734.1|WP_117508340.1|3054326_3054803_+|sigma-70-family-RNA-polymerase-sigma-factor
MDTEQRFIELIEHHKRIIYKVCYVYAPGRGQIDDYFQEVVLALWRGFPDFRGESKTATWVYRIALYTCISFVRRRMRRPQSVRLSVDLACDDDMQAREQLDELYAVISRLGRLDRALILLWLEEHPAGEIAAITGLSPGNVAVKLTRIRCKLRKMYNR
>NZ_AP019734.1|WP_141417969.1|3052923_3053985_-|site-specific-integrase
MRSTFKVLFYLKRNKDKDQKVVPVMGRITVNGSIAQFSAKLSVPEMLWEVSGGRAKGRSLEADRINRHLDNIRTQIGKHYQDICDRESYVTAEKVKNAYLGFGEKYRLLLEAFEKFTGDLKKRVGIDRCHGTWNRYYKSIDHLRTFMRKEYNVSDMPLAELEQSFIEQYHVYLKSDLGLKPTTVSGYLKCLKYVVKIAFNNGWMPRNPFSLYQYTAPNPERSFLTEDELRRMMTTELRYKRQDYNRDMFLFSCFTGICYADMASLTYDRIEQDAQGEWWISGNRQKTETRYVVKLLPYALFILNKYRGLTGDGRVFAMSTLDSIDDSLKNIARECGIDKQLSFHMAKHHTISI
>NZ_AP019734.1|WP_117508330.1|3068210_3069461_-|hypothetical-protein
MNRLLPVIALAVLAYPAAPVSGQSGEENAKPPIFWDGGMIPDPGFRAYVLENFDTDRDGKISSEEADAVLVIDLGREEPTDTPGIKSLEGVEYFKNLRELIGAFHPLTSLRLSENMALTKLNCRDSQLTALDLSKNKALTLLDCAYNQLTALDLADNTALIGLDCSGNQLSVLDLTQNPELTGLNCSHNRLTALDLTGNPALTQLDCRDNRLTSLDLTGNPALTQLDCRDNRLTALDLAQNTALIRLDCHNNRLTALNLTGNPMLTELVCSYNLLPTLDLSENTMLTDLWCESNRLTSIDLSQNKALSRLYCDNNRLTTLDLSANTALTGLSCHDNRLTALALSKNTKLVALGCCDNPLIRLNLSDLAKLGAISLDYDNYKIQVITNSRTAIVSSLTRYMQSIEAEKQKKHLQQEE
>NZ_AP019734.1|WP_141417971.1|3069457_3070867_-|hypothetical-protein
MKRFLPITVLAVFAYPAATISCQSGKKAADPQIFWDGGAIPDPVFRTYVLDNFDTDRDGKISRKEADAVLAIDLGRLCAELGPATESLAGIEYFKNLKQLICNGNTLAELDLSQNTRLTELNCWDNPLPALNLSKNTELVKLNCNYTALAELDLTQNTALTELACEGNPLTSLDLSKNTKLTVLFCPANQLTALDLSKNTALKELLCYSNRLTGLDLTQNKELVHLHCYYNQLTSLDLSQNTALEELLCYENQLTALDLSKNAALIQLNCYNNRLRALDLSENTALTKLFCGYNPLTELDVSRNTKLTELLCHENQLTALDLTHNTALATVYCPNNRLTALDLSKNTALATLACSRNQLTALDLSQNTAITELYCNNNQLAALDLSRNTALTELYCNGNRLTTLDLSRNTELTKIYCDDNPLTELNISNLSKIEEIVFGDNPEINVIANSQTVVSDEVRHYMDGKRKTP
>NZ_AP019734.1|WP_117508328.1|3070953_3071790_-|HAD-family-phosphatase
MQIRLILLDFDGTLADTRRANTLAYVATLREAGYTLTEEEYAAKYFGMRCNEFLTRYGIADPAERERLRLRKIALYPAFFDTVRLNRPLWEFCRQFRAQGGRVWIVSTGSRANIDNAMRHLGITVAGQLTGSTAPAGCAGMDEAGMVGAGKGTTATGMDGAGVEGTGKGTAGADVDTTGAGNTAPGAAGSYTATAGTGAATPGAAWDPAPGEGPNGSVDGILSGTDVEHSKPAPDCFLEAMRREGCTPQETLIFEDSEIGLEAARRSGASYFVVKLDT
>NZ_AP019734.1|WP_117508327.1|3071796_3072213_-|MmcQ/YjbR-family-DNA-binding-protein
MGNDWTKDFGFAREEIFRSEETLRTIRHIRASWGCEPEFLWEKFPDYAVFRRQDNAKWYAVILTVQAGKLGLADEGRTEILDIRADAETMARALDFEHYFPGYHMNKRTWLTVRLDGSVPFGEIAPLIARSYELAGKK
>NZ_AP019734.1|WP_022331685.1|3072224_3073175_-|M23-family-metallopeptidase
MAGKKDLERLRRRKRRKQNIIRATVHFFVWAGVAVLYYIGFSLFFDTPVEYELKHSTDRLRREYAALTQRYDSLTTVMHNLSERDRNVFRILFESDPYDFDSEYERRQAVTYENIFNRSSRRLKLELRERVADMEKRLDELNASYLDLQALIDSAGSGCNNIPAIQPVINKQLTLLTASYGMRIHPFYKTLQSHQGVDYTIPEGSRVFATADGVVRDVALRNSTSGQTVVIDHGNGYETSYSHLSKINVRKGQRVSRGEIIALSGDTGLSLSPHLHYEVRLNGMRVDPIHYFFMELTPTEYQRLMRIAQSGMQSFD
>NZ_AP019734.1|WP_117508326.1|3073176_3074175_-|M23-family-metallopeptidase
MKQKGQRFDTQALTQEAQALTRDVVTAPFRLRTYRLIRKILIGFILVSIANVLFSYFFYTPKMYRIIRDNRDLVIKYRILQDRIRTSQRRVDEIRHRDNYVYRSLFSTDTVSIDGVWQPYPDTKYAAMAGDDFAPLMVGTWKQLDALARILYLESVSFDELQAFARDKEKMSAAIPAIWPIDRSALHNDHIGAFNLRRMHPVLGYIRPHKGIDLGCDRGTPVYATGDAVVEVASSGGNGGYGHMVLLNHEFGYKTRYAHLSKVLVQPGERVARGQVIAETGNTGISSGPHLHYEVIHKGMPVNPINYFNRNMTAAEYDALMENMRDTNFEKL
>NZ_AP019734.1|WP_117508325.1|3074274_3076896_+|alanine--tRNA-ligase
MESNKIRRAFLDFFESKGHVIVPSAPMVVKGDPTLMFTNAGMNQFKDIFLGNAPRKYPRAADTQKCLRVSGKHNDLEEVGHDTYHHTMFEMLGNWSYGDYFKKEAIEWAWELLHGVYKLPADRMYATVFEGSEEDGVPFDQEAYDYWKQFLPEDHIIRGNKHDNFWEMGETGPCGPCSEIHFDLRDEAEIAAEPGRGMVNEGHPQVIEIWNLVFMQFNRKANGSLEELPARNVDTGMGFERLCMILQGKKSNYDTDVFQPTIQRISQLSGKTYGADAKCDVAMRVIADHLRAIAFSIADGQLPSNVKAGYVIRRILRRAVRYGYTYLGFTEPTICKLVAGLVEQMGGQFPELKAQQALIEKVIEEEEASFLRTLATGISLLDGVVEKTKKEGRELISGKNAFELYDTFGFPIDLTELIAREQGVGVDLAAFETELQAQKERSRNAAAVDTDDWVELFPIRESVFTGYDTLTERVKIARYRRVTSKGKTSYQLVFDRTPFYGNSGGQIGDIGYIENANERIAVVATEKENGLIIHIVKELPENPAAEFTAVVDAAKRQAAANNHTATHLMHEALRKVLGSHVEQKGSMVTPEILRFDFSHFQKMTPAELRQVEMLVNRAVRANYPLEENREATKEEAEKCGAMMLFGEKYGDRVRMVRFGTSVELCGGTHTSATGNIGFFKILTESAISAGVRRIEAVTGEQAEKIIYAAEDTMRDISEYLHNPQVLQAVKKMFESNETLSKEVEAMRREQVAQWAEKIISSTPERHGVQLIATQTDRTPEFVKDLAYNLRARSPKLVFVQGAVNDGKPMLTVMLGDEITAQGVNAGAVVREAAKLMQGGGGGQAFFATAGGKNPDGLQAAIDKAVELIMAQVK
>NZ_AP019734.1|WP_117508324.1|3076921_3078448_+|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MNNKVLLMILDGWGNGRHDKADVISTVHPEYISAMTAKYPHAELRTDGGNVGLPDGQMGNSEVGHLNIGAGRVVYQDLVKINRACRDNSILENPEVKAAFEHAKKNGVNMHFMGLVSDGGVHSSLEHLFKLCDISAAYGLENTFVHCFMDGRDTDPHSGKGFVADLEKHLAATTGKIATVIGRYYAMDRDKRWERVKVAYDALVSGIGERSSDMVEAVQKSYDEGVTDEFIKPFVRIDENGQPVGMIRPNDVVVFFNYRNDRAKELTIVLTQEDMPAEGMHTLPLYYCCMTPYDAKFTGLHILFDKENVPNTIGEFVSKQGLRQLRIAETEKYAHVTFFLNGGREAEFAGEDRILVASPKVATYDLQPEMSAPEVADKLVAALGERKFDFICLNFANGDMVGHTGVYDAIVKAVKAVDGCVAKVVEAAKENGYEVVMIADHGNADNAVNADGTPNTAHSLNPVPIVVVSDRVKSVHDGILADVAPTVLRLMGLEQPAEMTGKALVEMK
>NZ_AP019734.1|WP_117508323.1|3078694_3079978_+|site-specific-integrase
MFSIKVKGKPNPKNSNLVKLELVFFQTDYPRVTKVLDITGQYKDWDERSQTFRNGSPDAYSKNRSLSEVCMRYQRVAEEWTVSGLFWSPVELSHCFDRQQSAVRQDIRIWTVSQLIDERITYFDSKDRIKNGQIILSSSNARKYEKFHRSLKAFVSAVYGKSLSSYFFKDIDAKFLTDYAFYLKRRGAENGNQGCLVSHLRLLRALCNYAAKLGMPGAGITAFDSLGDMIKWPETTSRAVSAKTIALLENIDRSLFSAKEQLHLDLFRFSYYTGGMANVDVCNLTWDCVQEDKIVYERIKFPKTAKPLLTPPQSRALLRKYKGTGSGNYVFPVFTRKHTDSVKRYTRVHQISNLVTRTLTKACRILKIKEHVTWYSARGSFISRMVDDGNSPYAVAEMAGNSPMTIWKNYYKNTEREKLAERTRAVL
>NZ_AP019734.1|WP_141417972.1|3080179_3080662_-|hypothetical-protein
MKTRLILFILFTILIAKVCGQEQSNSDQYPLLIPVNESRQRLKIEIPCKCITDSLEVVVSVGVHFDNEVSDTTTTLTPIKIYIGSIIYHKGTPKQVYLSNKQSLNNSYDRCIWKTCSDKFLVWMECQPYSRFFNRENQPKGGKGLSFTYKVMLTPDIELP

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

664613 : 730574

unidentified_phage(61.11%)

integrase,tail,portal

attL 667894:667953|attR 671303:671382

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_141417556.1\|664613_665849_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_141417557.1\|665959_666256_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_162508116.1\|666462_667755_+	hypothetical protein	NA	NA	NA	NA
667894:667953	attL	NA	NA	NA	NA
WP_117722017.1\|668018_669269_+\|integrase	tyrosine-type recombinase/integrase	A0A142F1N9	Bacillus_phage	1.2e-05	17.9
WP_118419102.1\|669285_670245_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_117722019.1\|670250_671282_+\|integrase	tyrosine-type recombinase/integrase	A0A0K2CP59	Brevibacillus_phage	9.5e-20	27.9
WP_141417559.1\|671533_672175_-	hypothetical protein	NA	NA	NA	NA
671303:671382	attR	NA	NA	NA	NA
WP_141418028.1\|672177_672456_-	HU family DNA-binding protein	NA	NA	NA	NA
WP_141417560.1\|672700_673720_-	hypothetical protein	H7BUI9	unidentified_phage	5.4e-100	49.9
WP_141417561.1\|673755_675168_-\|portal	phage portal protein	H7BUJ0	unidentified_phage	1.4e-170	61.8
WP_141417562.1\|675674_676109_-	hypothetical protein	A0A1B1IRB1	uncultured_Mediterranean_phage	2.5e-22	41.5
WP_141417563.1\|676647_678270_+	hypothetical protein	NA	NA	NA	NA
WP_141417564.1\|678259_678706_+	hypothetical protein	NA	NA	NA	NA
WP_141417565.1\|678787_679225_+	hypothetical protein	NA	NA	NA	NA
WP_141417566.1\|679306_679561_+	hypothetical protein	NA	NA	NA	NA
WP_141417567.1\|679772_680219_+	hypothetical protein	NA	NA	NA	NA
WP_141417568.1\|680309_680741_+	hypothetical protein	NA	NA	NA	NA
WP_141417569.1\|682341_682641_-	hypothetical protein	NA	NA	NA	NA
WP_141417570.1\|682637_682847_-	hypothetical protein	NA	NA	NA	NA
WP_141417571.1\|682954_683572_-	hypothetical protein	NA	NA	NA	NA
WP_141417572.1\|683555_683774_-	hypothetical protein	NA	NA	NA	NA
WP_141417573.1\|683778_684081_-	hypothetical protein	NA	NA	NA	NA
WP_141417574.1\|684077_684257_-	hypothetical protein	NA	NA	NA	NA
WP_141417575.1\|684225_684768_-	hypothetical protein	NA	NA	NA	NA
WP_141417576.1\|684827_685118_-	hypothetical protein	NA	NA	NA	NA
WP_141417577.1\|685127_685892_-	3'-5' exonuclease	H7BUJ3	unidentified_phage	1.5e-70	55.0
WP_162508117.1\|685873_686407_-	hypothetical protein	E0YIZ7	Lactococcus_phage	3.2e-11	37.6
WP_141417579.1\|686403_688575_-	DNA polymerase III subunit alpha	H7BUJ5	unidentified_phage	1.0e-257	58.8
WP_141417580.1\|688571_690281_-	PHP domain-containing protein	H7BUJ7	unidentified_phage	2.8e-141	53.9
WP_141417581.1\|690277_691336_-	hypothetical protein	H7BUJ8	unidentified_phage	3.6e-107	57.1
WP_141418029.1\|691568_691880_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_141417582.1\|691890_692979_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_141417583.1\|693129_694485_-	hypothetical protein	H7BUJ9	unidentified_phage	1.1e-135	52.3
WP_141417584.1\|694481_695099_-	hypothetical protein	NA	NA	NA	NA
WP_141418030.1\|695073_695676_-	RNA polymerase sigma factor	NA	NA	NA	NA
WP_141417585.1\|695818_696298_-	crossover junction endodeoxyribonuclease RuvC	NA	NA	NA	NA
WP_141417586.1\|696269_698588_-	SMC family ATPase	H7BUK0	unidentified_phage	1.9e-113	33.4
WP_141417587.1\|698575_699634_-	phosphoesterase	M4SN99	Cellulophaga_phage	4.2e-15	22.2
WP_141417588.1\|699639_700224_-	hypothetical protein	A0A218KBR8	Bacillus_phage	2.8e-37	46.9
WP_141417589.1\|700287_701544_-	hypothetical protein	H7BUK1	unidentified_phage	2.3e-84	45.4
WP_141417590.1\|701863_702325_-	hypothetical protein	NA	NA	NA	NA
WP_141417591.1\|702439_704998_-	hypothetical protein	NA	NA	NA	NA
WP_141418031.1\|705000_705555_-	hypothetical protein	NA	NA	NA	NA
WP_141417592.1\|705554_706439_-	hypothetical protein	H7BUK7	unidentified_phage	3.3e-82	50.5
WP_167496244.1\|706458_707529_-	hypothetical protein	H7BUK8	unidentified_phage	1.8e-34	36.2
WP_141417593.1\|707521_708202_-	hypothetical protein	NA	NA	NA	NA
WP_141417594.1\|708389_709427_+	Fic family protein	NA	NA	NA	NA
WP_141417595.1\|709524_710913_+	DUF4062 domain-containing protein	NA	NA	NA	NA
WP_141417596.1\|710916_712341_+	hypothetical protein	NA	NA	NA	NA
WP_141417597.1\|712732_714031_+	AAA family ATPase	NA	NA	NA	NA
WP_141417598.1\|714027_714225_+	hypothetical protein	NA	NA	NA	NA
WP_141417599.1\|714228_714552_-	RNA-binding protein	NA	NA	NA	NA
WP_141417600.1\|714570_714852_-	hypothetical protein	NA	NA	NA	NA
WP_141417601.1\|721084_722743_-	hypothetical protein	NA	NA	NA	NA
WP_141417602.1\|722739_723648_-	hypothetical protein	NA	NA	NA	NA
WP_141417603.1\|723886_724111_+	hypothetical protein	NA	NA	NA	NA
WP_162508118.1\|724101_724413_+	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
WP_141417605.1\|724577_725936_-	hypothetical protein	NA	NA	NA	NA
WP_141417606.1\|725926_726877_-	hypothetical protein	NA	NA	NA	NA
WP_141417607.1\|726881_730574_-\|tail	phage tail tape measure protein	B9A7B3	Serratia_phage	1.2e-24	27.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP019734

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection