CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP019739	Alistipes communis strain 6CPBBH3	23 crisprs	RT,DEDDh,WYL,PD-DExK	5	1	3	3

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_AP019739_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_1

43291-43461

Orphan

Consensus_repeat	Method
TGCACTCGGCTTAATCGTATCTTTGGCTGACGCC	PILER-CR

2 spacers

The CRISPR arrays of NZ_AP019739_1

>merge|NZ_AP019739|1|43291-43461|PILER-CR
TCGTACCTTTGGCTGACGCCTGGTGGGTACTTCGCCTCGGCAAAAAGCAAATAAATTTGCATTGCATTCGGCTTAATCGTATCTTTGACTTCGTCGTAGATACTTCGTCTCGGCATAATCAAGCTGGCGCTTGCTTCTGCGCTCGGCTTAATCGTATCTTTGGCTGACGCC

>NZ_AP019739|1|1|43291-43461|PILER-CR
TCGTACCTTTGGCTGACGCCTGGTGGGTACTTCG	CCTCGGCAAAAAGCAAATAAATTTGCATTGCATTCGGCTTAA
TCGTATCTTTGACTTCGTCGTAGATACTTCGTCT	CGGCATAATCAAGCTGGCGCTTGCTTCTGCGCTCGGCTTAATCGTATCTT
TGGCTGACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141418074.1\|39283_39667_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379907
NZ_AP019739.1\|WP_019130552.1\|35865_36876_-\|YeiH-family-putative-sulfate-export-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_AP019739.1\|WP_141412592.1\|52193_53066_+\|DUF4296-domain-containing-protein	unknown	unknown	gnl\|CDD\|379487
NZ_AP019739.1\|WP_019130539.1\|46994_47621_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019130554.1\|33563_34847_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|274232
NZ_AP019739.1\|WP_026074920.1\|37205_38198_+\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|223117
NZ_AP019739.1\|WP_141418081.1\|47617_49711_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379073
NZ_AP019739.1\|WP_019130540.1\|46500_46998_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|238269
NZ_AP019739.1\|WP_034779709.1\|50539_50893_+\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|376719
NZ_AP019739.1\|WP_141418077.1\|42262_43165_-\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NZ_AP019739.1\|WP_141418079.1\|43640_45140_+\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NZ_AP019739.1\|WP_141418075.1\|39733_41497_-\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|273193
NZ_AP019739.1\|WP_141418082.1\|50905_52135_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_AP019739.1\|WP_141418076.1\|41502_42183_-\|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl\|CDD\|319743
NZ_AP019739.1\|WP_141418071.1\|32144_33497_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl\|CDD\|223842
NZ_AP019739.1\|WP_141412587.1\|45152_45338_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418073.1\|38936_39137_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_051014427.1\|49720_50533_+\|outer-membrane-beta-barrel-protein	unknown	unknown	gnl\|CDD\|372635
NZ_AP019739.1\|WP_141418080.1\|45344_46490_+\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|273213
NZ_AP019739.1\|WP_141418072.1\|34836_35871_+\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|376607

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141418074.1\|39283_39667_+\|hypothetical-protein	gnl\|CDD\|379907	pfam16962, ABC_export, Putative ABC exporter. This is a family of putative ABC_exporters from Firmicutes.	0.00865522
NZ_AP019739.1\|WP_019130552.1\|35865_36876_-\|YeiH-family-putative-sulfate-export-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	5.62431e-101
NZ_AP019739.1\|WP_141418082.1\|50905_52135_+\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	7.4104e-44
NZ_AP019739.1\|WP_019130554.1\|33563_34847_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|274232	TIGR02614, Putative_lipid_II_flippase_FtsW, cell division protein FtsW. This family consists of FtsW, an integral membrane protein with ten transmembrane segments. In general, it is one of two paralogs involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division. All members of the seed alignment for this model are encoded in operons for the biosynthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein (peptidoglycan). The FtsW designation is not used in endospore-forming bacterial (e.g. Bacillus subtilis), where the member of this family is designated SpoVE and three or more RodA/FtsW/SpoVE family paralogs are present. SpoVE acts in spore cortex formation and is dispensible for growth. Biological rolls for FtsW in cell division include recruitment of penicillin-binding protein 3 to the division site. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	1.6705e-54
NZ_AP019739.1\|WP_026074920.1\|37205_38198_+\|malate-dehydrogenase	gnl\|CDD\|223117	COG0039, Mdh, Malate/lactate dehydrogenases [Energy production and conversion].	4.97652e-54
NZ_AP019739.1\|WP_141418081.1\|47617_49711_+\|hypothetical-protein	gnl\|CDD\|379073	pfam13205, Big_5, Bacterial Ig-like domain.	1.45743e-15
NZ_AP019739.1\|WP_019130540.1\|46500_46998_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	7.92152e-46
NZ_AP019739.1\|WP_034779709.1\|50539_50893_+\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|376719	pfam02033, RBFA, Ribosome-binding factor A.	1.24164e-32
NZ_AP019739.1\|WP_141418077.1\|42262_43165_-\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	1.11316e-171
NZ_AP019739.1\|WP_141418079.1\|43640_45140_+\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	3.86334e-25
NZ_AP019739.1\|WP_141418075.1\|39733_41497_-\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|273193	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ. All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	2.36477e-168
NZ_AP019739.1\|WP_141418076.1\|41502_42183_-\|lipoyl(octanoyl)-transferase-LipB	gnl\|CDD\|319743	cd16444, LipB, lipoyl/octanoyl transferase. Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.	5.80679e-97
NZ_AP019739.1\|WP_141418071.1\|32144_33497_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl\|CDD\|223842	COG0771, MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane].	1.32249e-147
NZ_AP019739.1\|WP_141412592.1\|52193_53066_+\|DUF4296-domain-containing-protein	gnl\|CDD\|379487	pfam14129, DUF4296, Domain of unknown function (DUF4296). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 90 amino acids in length.	7.83103e-05
NZ_AP019739.1\|WP_051014427.1\|49720_50533_+\|outer-membrane-beta-barrel-protein	gnl\|CDD\|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	1.91812e-10
NZ_AP019739.1\|WP_141418080.1\|45344_46490_+\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|273213	TIGR00678, DNA_polymerase_III_subunit_delta', DNA polymerase III, delta' subunit. This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair].	1.63429e-51
NZ_AP019739.1\|WP_141418072.1\|34836_35871_+\|acyltransferase-family-protein	gnl\|CDD\|376607	pfam01757, Acyl_transf_3, Acyltransferase family. This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterized C. elegans proteins and it is approximately 300 amino acids long.	1.7464e-14

>NZ_AP019739.1|WP_141418077.1|42262_43165_-|lipoyl-synthase
MPKLYDNKVDVAKKPGWLKIRLHRTTQFAEVDRIVREHALHTICSSGMCPNKAECWSRRTATFMILGDVCTRSCRFCATRTGRPLPPDDAEPGQLARSVKLMGLRHVVVTSVTRDDLPDGGARHWAAAVEAIRRENHDATIELLIPDFDARPELLDTVVAAKPDIIGHNIETVERLTPQVRSRARYATSLRTLELLARRGAATKSGLMLGLGESDDEVLQTLRDLRRAGVRIVTLGQYLRPTLEHYPVAEYITPEKFEAYRQQALAMGFDYCASAPMVRSSYRAQEALAAIKNEKSETRH
>NZ_AP019739.1|WP_141418076.1|41502_42183_-|lipoyl(octanoyl)-transferase-LipB
MLTVRTIDLGRVPYRDCWEYQQRLFDVLTARRGDASDDAGWLLTVEHPPVYTLGKSGKAQNLLVGEEFLRAKGAEYYHIDRGGDITFHGPGQAVCYPILDLARLGIGLREYIFRLEESVIEVVGRYGIRGARIAGASGVWIVEEGAAPRKICAIGVRASRFVTMHGFALNVSTDLEWFGLINPCGFVDRGVTSIERETGRTVPMDEVKKSIVTVLSEKLDVKIYNK
>NZ_AP019739.1|WP_141418075.1|39733_41497_-|single-stranded-DNA-specific-exonuclease-RecJ
MPIEKRWVVKPQGDPATVEALASALRIPPVLANLLVQRGIDTEEKAHSFFNPQLSDLHDPFLMKDMDRAVERVEAAVRNQEKIMVYGDYDVDGTTAVALVYKFLRHIGHRNLLFYIPDRYTEGYGISVKGIDYAARKGVTLIIALDCGIKATEKVAYAKTQGVDFIICDHHLPAEEIPRAVAVLDPKRTDCTYPFDELSGCGVGFKLVQAYAMKNGMPFSSIAPLLDLLVVSIASDIVPLVGENRILAHYGLELLNRAPSKGLLSIIKICGLNKHSITIDDIVFKIGPRINAAGRMRMDENDENAAPSGGYAAVNLLVENNESDAEDYGSIIDAFNQDRKSIDRHVTQEAHEIIESDPELKNCKSTVIYNPRWMKGIVGIVASRLIETYFRPTVVLTQSNGFATGSARSVPGFDLYQAVESCADLLENFGGHMYAAGLTMRPENVGEFTRRFNAYVEENIDPQMLVPQVDVDAELLFSEITPAFRRELKRFEPFGPGNAAPIFATRSVSNRGDAKLVGAECEHLRMDLTQRQKPNTTLQCIAFQQPEHFEWIRSGRPVDVCYQIVENHYRGTVSTQLRIKDIKRVEK
>NZ_AP019739.1|WP_141418074.1|39283_39667_+|hypothetical-protein
MTLLPSESQQPDGRLSLVWTMVYALAAAFAFGFFNDVVVGRWHPELNEGAQVPRPRESVRRPLALFLYVFVGLYFFSALAFLSRGAADEPFAAGRMSVAALVAAVLLTAIFYGMKRLLCRRSGGREA
>NZ_AP019739.1|WP_141418073.1|38936_39137_+|hypothetical-protein
MSRTSRFLVRTLMWFVGLFVIDTACTLWLWREPYSPVRTLGYSLVVAWVFALLDHLFDPFAQGRKN
>NZ_AP019739.1|WP_026074920.1|37205_38198_+|malate-dehydrogenase
MAFLTNEKLTIVGAAGMIGSNMAQTALMMGLTSNLCLYDVFSPEGVAEEMRQCGFDGVNITATTDVKEAFTDAKYIISSGGAPRKAGMTREDLLKGNCEIAEQLGKDIKTYCPDVKHVVIIFNPADLTGLVTLLYSGLKPSQVTTLAALDSTRLQSALAKKFGVMQNQITGCATYGGHGEQMAVFGSAVKVAGKPLSEIIGTAEFPVEEWKQMQQDVTKGGAKIIELRGRSSFQSPSYLSVEMIRSAMGGEAFRWPAGTFVNNEKYKCIMMAMKTTLDATGCHFEVPTGTADEVASLDASYEHLCKMRDELVTLNIVPPVSEWSKINPNL
>NZ_AP019739.1|WP_019130552.1|35865_36876_-|YeiH-family-putative-sulfate-export-transporter
MFSEKHGNILHGILLIALFSCAAFYLADTQPARSLSFSPLILGILLGMLYANSLRNHLPETWVPGILFCSKQLLRAGIVLYGFRLTFQSVAAIGAPAIGIDAAVVAGTLLLGVLLGRALKMDRDLALLTSTGSAICGAAAVLGAEPVVKAAPHKTAVAVSTVVIFGTVSMFLYPALWRAGILGLTPEQMGLYTGATLHEVAHVVGAGNAMGAEIADGAVIVKMIRVMMLAPVLLVMSLLLARRTKGGAGRAKVTIPWFAFGFLAVIGFNSLDLLPEAAVAGINSFDTFLLTMAMTALGAETSIEKFKRAGAKPFLLAGLLYLWLLGGGYLLSRWIL
>NZ_AP019739.1|WP_141418072.1|34836_35871_+|acyltransferase-family-protein
MKSSPIPTSRPADRLPRDRRIDLCYVIGILLVVAGHSGVDPRFASTALFRWIYAFHMPLFFALSGYLFRYGGGSGQVGAGTFARRRALRLLLPLVVWTTLVFIPKGLLSAYAMRPSELSFSAYLHAFLYPADNPIRPFWFLEVLFEVSLAGYAVDRIVRSRPAALAAVAGTCIAANRLIAPTGGELLMLPDVLWYTGFFLLGAVACDGRTWLWPRLARPSSLVFWGAASLVTLRFPSHVAAPFYAAAGILFVASCAALAVDRRLRLPLADDLRRYTFTVYLLHVLPVGLLRGLLYPRLAVDPALFSALLFLSGVLIPWAVGRMARRWIPSSTAGGRLSLRLLGL
>NZ_AP019739.1|WP_019130554.1|33563_34847_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MKETRSSETASSAPQSGLRALVGSVFTGDRVLWIIIAALAVISVLVVYSSTAKMAYDAHTARSTAHFLRQQVGILILCVPIIVIVHKINCRVYNRLAQPVYVLSLLLTLAVYFIGATTNGAARWIPVAGFQFQPSEALKVATILLLARRLSSCQSKIDRIRIVPSLNPFRWGRPAQRKIWREGTRPILLPVVLSCAVIFPAHTSSAMLVFLTSLVMMLIGRVRVSELVRLVGLACAALLLAGLLNLGRSETAGGRVSTWIDLWTSSQTEKPIDRLTDTERSMIAIHNGGLLGEGAGQSAMRVEMIHPESDYAYAFFVEEYGIILAGILLMLYLWIFFRAREIFVRCGTAFPGLLVLGLALMITCQALLHVMVTVNLMPETGQTLPLISRGGSSVLFTVIALGMILSVSRQNDEHSHDTPRSESIYEK
>NZ_AP019739.1|WP_141418071.1|32144_33497_+|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MKKLVVLGGGISGYGSAILARRKGFDVFLSDSGRIADRYRMKLEAWGVPYEEGGHSEERILAASECVKSPGIPDSAPIVRKLRERGVPVISEIEFAGRYLDGARTICITGSNGKTTTTSLVYRILRDAGCNVALGGNIGESFAYSVATGRYDWHVLELSSFQLDGMFRFRADIGVLTNITPDHLDRYDHSFAKYAAAKMRIAQNQRAGDYFIYSADDETIWSLLPSYRLPQRQLPFAARAAVAGSDGDAFLSRDGRFTAAVGDRSVEIDTRRMRIGGLHNAYNAMAAALAALAAGVAPDRIRRSIYAFAPVEHRLEPVRETDGVLWINDSKATNVDSVWYALESMKRPVVWIAGGTDKGNDYEPLKAFAREKVHTLVCMGVDNRKLVESFTGVVPEVISTASLDEAMEAARRAARPGDAVLLSPACASFDLFRNYEQRGELFKKWVGEHC
>NZ_AP019739.1|WP_141418079.1|43640_45140_+|oligosaccharide-flippase-family-protein
MLEKLAKQTAVYGISTIAVRFLSYLLTPVFTRVFEPEAYGIVTDVYALIPFALVVLTMGLESAYFRFAAKADAAAAAAGGTEGEIAARARAGKRRLFATAWGVTLLAASLFFLLTAFGRERVAEWMGEAYVAHPEYVLLVAAVVWFDVAACLPFSRLREQSRAMTFVGIKALGVVVNVALAIGFALAGLYGTPFGVGWVFVANLIASAVTFNVILLTTDRTVPRIDRRLLAAVLVYSLPLLVSGVAGTANEFIDRQMIKYLVPAGAMAQLGVYGAITKIAVVMMLFTQMYRLAAEPFFLADYRKSDFVAMNAAAMKYYVMASMFIFLGIALFKDLFSLIVGADFREGIFILPVVLGANVLSGVWLNLSFWYKREERTQLAVWVTFTGLFFTVVMNVALVPALGYVGAAWARLASEAAMVGVSYWLNRRYYPTPYDLRRIGEYVALGLGVFFASAVFARWLPVRGAEYAVNGVLFGLFGLFAVRREHIDVGRLLRSVVKR
>NZ_AP019739.1|WP_141412587.1|45152_45338_+|hypothetical-protein
METKNKLLILSLSFAIFIVGVRALYSEPGVVRNGVLAASVMGLVAIAVVQTVRAVKRNKKR
>NZ_AP019739.1|WP_141418080.1|45344_46490_+|DNA-polymerase-III-subunit-delta
MQFRDIIGQEELKRRLVASVAAGRVSHAQLFTGAAGAGTLPLAVAYAQYLNCRHRADGDSCGVCPDCRQIAALAHPDLHLVFPVNKQGKKSGEVITSDAFLPLFRTVFARSNGYFSPQEWYDALDLGKTLRGAISAREADEIIRKLSFKSFEAEYKVMLVWLPETMNEEAANKILKILEEPWEKTVFLLVSEAPDRLLQTILSRTQEVAVPRISTEVLEAVAARHGQSDPARLHNLARLAGGDYLTLQRLLAGEDDELTRDCFGLFCSLMRLSYNDKHLELVSWAEEVAHLSREQQRAFLRHAARLLRESYMLHAGLADISYLWGAEADFCGKFAPFIGNENVEFLLDEIERAMRQITQNGNPTIVFTHFALSVSKQIRRK
>NZ_AP019739.1|WP_019130540.1|46500_46998_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MARVVLLTGGNVGDVKERLRTAQRLVNARIGAVLRCSHCYGSAPWGFEAEQPFVNQVLVADTDLAPHEVLAEVHRIERELGRNRAAEAVERAATGQRYVSRPIDIDILLYDDEVISTPELTIPHPGIAEREFVLTPLCEVLRQRPHPVLGLTMGELRDNLLRKTK
>NZ_AP019739.1|WP_019130539.1|46994_47621_+|hypothetical-protein
MKRTILYAAAALLLGGCFKSVGYDTDVILKSWVQTESAAELKPAQGVVAYAFEADTVTWTVASYEDALNGVLTRKGTDEAGVSPVQGTAYRVDSVDMDLLLMRVGSTPVVVVAVDTENRLYGYRQQDLGENLPQLFTSVIFRPWKQMKKYVDGTWRMFNDFYVEEPDNPGGETGGETGGETGGETGGETGGDSSGSQGSGVDNRNIRR
>NZ_AP019739.1|WP_141418081.1|47617_49711_+|hypothetical-protein
MRTSDKDKRQGFVPLLGRAALAVFFCTAFLWRCATIMTPTGGPKDTLPPVITLMTPDNFTTNFKDRKIYIEFDEFVQIKDQQKEFFTSPQMKKKPTITLRGRGISVQLRDTLRENTTYALNFGSAICDNNEGNPLYSMRYVFSTGPEIDSMVLSGYTVDAYKADSVSKSFIYFYIADSVPEPKEYDSTLFNYKPQVIARAETNGIFLAQNLKPVPYRVYAFQDTNDNQMYEPSIDKVGFLDSLINPALMPDFSVWYDSLRHYVTADPQVFMRMFTDVAFKRQTLQQSERPARHKAMLYFGAAHPEVTGLRFDSIPAERVIWDPQTVGRDTVALWFDVPSASLPDTIKGEITYFKHDTVNRLQEVTEPLKLAWRYIESKSEEKEREKLERERKRAEAAGEEWEEPEKPNPFKVNLSTTGDVNPLDNLKLEFDYPLRKLDSAAVQLTYTTEQQPEPRPAEVRFERDTANMRVWRLKSDWQLGGKYELLVPPGAFENIANEQNDSLRGTYTVADPEKFATIRLHVEGKAPDAKYVVQLLNGSNGLLQERRDVTTGDLRFDYVPAGEIRLRVIEDLNGNGRWDSGNLVERRQPERAEMYVNADGESTFATKENWEVELDIDMNELFAPITMESLIEQLEQQEMQRLSKYLDEQQQNRKNRKDDQQGQSSSGMGFGGAMGGLGSMGGSGGMGGALGGFGNSF
>NZ_AP019739.1|WP_051014427.1|49720_50533_+|outer-membrane-beta-barrel-protein
MKTMKFITLCASVLLAASAARAQHTVGVFGGFGTGTARFYPAQETKSVGGRFSGGFSWRYYSATRFVGCVGVDLEFLQRGFAYAPFASTTENEADYVYYTRKLNSFVVPLVWQPHFYLARRHLRVYLEAALTFSYNFDSSYVNDVARENGVEPWRGKYEFKTARDNRWGYGLAGGAGLAVLIGRFEVSAGARYYFGYSDILRNRNKYYDNAVDGAENPFWYTPQRSPMDNLMVRIGVAYRFAPEFKSWTVKRQKREKMKAGFDFGEKPQK
>NZ_AP019739.1|WP_034779709.1|50539_50893_+|30S-ribosome-binding-factor-RbfA
MTENLSMRQQKIARQIQRDMADIFSKEAASFLQGAMVTVTAVRVSPDFGYAKIYVSVFPFDRSTAVMAVLDKQNWLLRRSLGQRVHNQLKTVPEIQFFLDDSLEYIDNIDQLLREEK
>NZ_AP019739.1|WP_141418082.1|50905_52135_+|FtsX-like-permease-family-protein
MLAGWFARRYFFSKKSHSVINLIAGVSVVSVAVPVAAMIVLLSVFNGFEQLVRSMNSHFDADLTLTPREGQTFGIESLDTAALRRLPGVEAVSLALEQSALMEYRGRQAMVTVRGVADGYDRVVPVAECITAGDYAVRLGDLDRLVVGRGVAYELGLRSLGESDGVLYALRRTGFSSLLPVEGYTRRQAEVAGVFAADAQTDGRYLFTSLRLAQELFSYPDRASAAVVRVARGARPAEVKRRVAEAAGGAFEVRTRDELNASFYTIMQYEKWGIFLISLLVLVIASFSIVGTVVMLVLDKRPEFVALGAMGADTRFVRRIFFFEGGLIGVLGAGAGVVLGVGLCLVQHYFGVIEIPADSFLVKSYPVLLRGGDVAAVVAAFAVVMGAMTAVTVRRAVRADDMAAGRTAQ
>NZ_AP019739.1|WP_141412592.1|52193_53066_+|DUF4296-domain-containing-protein
MKRFIYILVSGLLLACSGYKIIPDEQLALIFHDAFLSNAYMQHRGMRPDSLNLYEPIFAKYGYTTADVQYTIGNFSKRKSARLSDVVEQAIKLLETEAEHLDREVSILDTIDNVARRTFRRTLYADSLVRVTRLRDTARLRFVFDSIRPGDYTIAFDYLIDSLDENTQLRASVWFERADDRRVNVSPTYLTRRRAAEYRREMKADTSMRRLVLDLYEIRSPKPKRPHMTVRNLRVVYTPDAAEAVDSLFLRQLNIKIFADDFCNPLPAPDRVALPADSLGTAAPAAADAR

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Crispr_ID: NZ_AP019739_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_2

113127-113226

Unclear

Consensus_repeat	Method
CTCGGCTTAACGAAAACGGTGAAT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_AP019739_2

>merge|NZ_AP019739|2|113127-113226|CRISPRCasFinder
CTCGGCTTAACGAAAACGGTGAATTTTTTTCTTCGTTTTCTCGCTTCGGCAAAGCTCGCGCAAGCGCGGCTCTGCACTCGGCTTAACGAAAACGGTGAAT

>NZ_AP019739|2|1|113127-113226|CRISPRCasFinder
CTCGGCTTAACGAAAACGGTGAAT	TTTTTTCTTCGTTTTCTCGCTTCGGCAAAGCTCGCGCAAGCGCGGCTCTGCA
CTCGGCTTAACGAAAACGGTGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019130481.1\|115958_116462_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419592.1\|107665_108895_+\|acyloxyacyl-hydrolase	unknown	unknown	gnl\|CDD\|378181
NZ_AP019739.1\|WP_141418111.1\|106701_107661_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019130492.1\|102363_103485_+\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_AP019739.1\|WP_141418112.1\|109162_110917_+\|DUF4091-domain-containing-protein	unknown	unknown	gnl\|CDD\|379121
NZ_AP019739.1\|WP_141418107.1\|101641_102241_-\|WbqC-family-protein	unknown	unknown	gnl\|CDD\|378083
NZ_AP019739.1\|WP_141418109.1\|105057_105489_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200385
NZ_AP019739.1\|WP_141418118.1\|123157_126457_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_141418110.1\|105490_106570_+\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|200384
NZ_AP019739.1\|WP_141418113.1\|110924_113036_+\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NZ_AP019739.1\|WP_141418114.1\|114046_114829_+\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_AP019739.1\|WP_026074911.1\|113246_114044_+\|DUF3108-domain-containing-protein	unknown	unknown	gnl\|CDD\|378635
NZ_AP019739.1\|WP_019130482.1\|114880_115816_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418106.1\|99678_101718_+\|beta-galactosidase	unknown	unknown	gnl\|CDD\|225789
NZ_AP019739.1\|WP_141419593.1\|119696_121241_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379837
NZ_AP019739.1\|WP_141418116.1\|118514_119381_-\|HAD-IIA-family-hydrolase	unknown	unknown	gnl\|CDD\|319858
NZ_AP019739.1\|WP_019130480.1\|116475_116958_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_162851472.1\|103494_104979_-\|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|179361
NZ_AP019739.1\|WP_141418117.1\|121344_123144_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NZ_AP019739.1\|WP_141418115.1\|116977_118375_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366737

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141419592.1\|107665_108895_+\|acyloxyacyl-hydrolase	gnl\|CDD\|378181	pfam09411, PagL, Lipid A 3-O-deacylase (PagL). PagL is an outer membrane protein with lipid A 3-O-deacylase activity. It forms an 8 stranded beta barrel structure.	2.49638e-06
NZ_AP019739.1\|WP_141418114.1\|114046_114829_+\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	6.83772e-17
NZ_AP019739.1\|WP_141418109.1\|105057_105489_+\|hypothetical-protein	gnl\|CDD\|200385	TIGR04134, hypothetical_protein, putative lipoprotein, rSAM/lipoprotein system. Members of this family are Bacteroidetes lineage putative lipoproteins that always occur in pairs with a radical SAM enzyme, TIGR04133, from a branch of the radical SAM superfamily in which many members perform peptide or protein modifications. In some members, the region distal to the Cys of the putative lipoprotein cleavage motif is duplicated.	4.07869e-24
NZ_AP019739.1\|WP_141418112.1\|109162_110917_+\|DUF4091-domain-containing-protein	gnl\|CDD\|379121	pfam13320, DUF4091, Domain of unknown function (DUF4091). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.	1.13866e-25
NZ_AP019739.1\|WP_019130492.1\|102363_103485_+\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	8.11538e-34
NZ_AP019739.1\|WP_141418110.1\|105490_106570_+\|radical-SAM-protein	gnl\|CDD\|200384	TIGR04133, coenzyme_PQQ_synthesis_protein_E, radical SAM enzyme, rSAM/lipoprotein system. Members of this protein family are radical SAM enzymes with an additional 4Fe4S cluster-binding C-terminal domain (TIGR04085) shared with PqqE and many other peptide and protein-modifying radical SAM enzymes. All members occur in the context of a predicted lipoprotein that usually is encoded by an adjacent gene.	0
NZ_AP019739.1\|WP_141418113.1\|110924_113036_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_AP019739.1\|WP_026074911.1\|113246_114044_+\|DUF3108-domain-containing-protein	gnl\|CDD\|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA\|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	1.31241e-47
NZ_AP019739.1\|WP_141419593.1\|119696_121241_-\|hypothetical-protein	gnl\|CDD\|379837	pfam16370, MetallophosC, C terminal of Calcineurin-like phosphoesterase. This is the C-terminal of Calcineurin-like phosphoesterases. It is around 150 residues in length from various Bacteroides species. The function of this family is unknown.	5.80407e-50
NZ_AP019739.1\|WP_141418106.1\|99678_101718_+\|beta-galactosidase	gnl\|CDD\|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	3.19902e-42
NZ_AP019739.1\|WP_141418116.1\|118514_119381_-\|HAD-IIA-family-hydrolase	gnl\|CDD\|319858	cd16422, HAD_Pase_UmpH-like, uncharacterized subfamily of the UmpH/NagD phosphatase family, belongs to the haloacid dehalogenase-like superfamily. This uncharacterized subfamily belongs to the UmpH/NagD phosphatase family and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	8.628e-86
NZ_AP019739.1\|WP_141418118.1\|123157_126457_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_162851472.1\|103494_104979_-\|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|179361	PRK02048, PRK02048, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional.	3.75486e-128
NZ_AP019739.1\|WP_141418117.1\|121344_123144_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	1.9216e-39
NZ_AP019739.1\|WP_141418115.1\|116977_118375_-\|hypothetical-protein	gnl\|CDD\|366737	pfam01640, Peptidase_C10, Peptidase C10 family. This family represents just the active peptide part of these proteins. Residues 1-120 are not part of the model as they form the pro-peptide, which before cleavage blocks the active site from the substrate. The catalytic residues of histidine and cysteine are brought close together at the active site by the folding of the active peptide.	6.69307e-11
NZ_AP019739.1\|WP_141418107.1\|101641_102241_-\|WbqC-family-protein	gnl\|CDD\|378083	pfam08889, WbqC, WbqC-like protein family. This family of proteins are functionally uncharacterized. However it is found in an O-antigen gene cluster in E. coli and other bacteria suggesting a role in O-antigen production. Feng et al. suggest that wbnG may code for a glycine transferase.	1.73206e-40

>NZ_AP019739.1|WP_141418113.1|110924_113036_+|ATP-dependent-DNA-helicase-RecG
MGNWYTDDVKYIAGVGEARAKLLDKELGIATVGDLLYHFPFRYIDRTKIYRIAEIGASGQTLVQFRGRVTGVAYAGAGRKRRFTAYVADATGQAELVWFQGIKWIEKRIEVGREYLVFGRPSFFRNELSLVHPEVETVEKALSRRAESGLQGIYSSTERLSSVLGTKGFHTIVSNAWRIAGERIGETLPPEMRRQYGLATLREALYNIHFPQSPEALRQAQYRLKFEELLGVQLNVMARRSERLARNDGFYFARVGESFNTFYREKLPFPLTGAQKRVVREIRQDTVTGCQMNRLLQGDVGSGKTLVALLSMLLAVDNGFQACMMAPTEILARQHYATLTRLLDGLTVRVAILTGASKARERRAALEGVASGEVQLLVGTHALIEDRVRFANLGLVVIDEQHRFGVEQRARMWTKNEQPPHVLVMTATPIPRTLAMTLYGDLDVSVIDELPPGRRPVRTVHYTDAARLRVWGFLRQEIARGRQAYVVYPLIEESESMDYKDLQDGYEAISRDFPLPEYVVEVVHGRMKPEDKEAAMRRFKSGEAQILVSTTVIEVGVDVPNATVMVIESAERFGLSQLHQLRGRVGRGAEQSYCILMSGEKLSKEARARLDAMCQTNDGFRLAELDLKLRGAGDIAGTQQSGMAFDLKIANPTLDVQILQLTRDAAGGVLAADAALAAPEHAGLRELKRRYSGEKSIDFSMIS
>NZ_AP019739.1|WP_141418112.1|109162_110917_+|DUF4091-domain-containing-protein
MKRTLSFLLPAAAMLLAACGGANDRPSFPDFQEMADPAAAFADWSAAGDTPCASFVTTDRRFGKSQLPDVEPRTACRLTAWRGERVSAQLLVWSAQPVERLVCTAGVLTSDEGRLPESAVRTRFVRYVMSDEFACGCCKRKPQDFAAVLTADMLDERPSMALEACTVRPVWITVDVPQDAAPGLYRTPVTVACDGDEQRLELAVEVTGRTLPAPSEWRYHLDLWQHPAAVARVEGTEMWSDAHFEALRPVMKPLADAGQKVVTATLNKDPWNNQCYDAYADMIVWTKGADGAWTYDYAAFDRWVEFMEGLGVDKQINCYSMLPWNNMLHYRDAATGEWVDVKAEPGQPAFDEMWRPFLADFVRHLEEKGWLAKTCIAMDERSPEQMEIAVAFLAEHAPQLGIALADNHDSYKRYPQLHDICVSARQEVAPEDIAARRAAGQVTTYYVCCSHRYPNMFTFSDPAEATVAAWYAVANGYDGFLRWAYNSWTEDPLRDSRFRTWPAGDTYVVYPGGRSSIRFERLCEGIQDAEKIRILRAEAGRGNSAGADEKRARLEAVIAPFASREPAADLHERLAEAKRVLNEL
>NZ_AP019739.1|WP_141419592.1|107665_108895_+|acyloxyacyl-hydrolase
MRVISASFAAVLLCLTVVSLPAPVRGESLRRPTPDSLARPQALVHKLGLDVSPGALFRTDDFFKGANAAGKEFGTTLSVHLKYAFQFGPETRFGRNYPFTYQGVGLGYNTFFNSAEVGTPVALYVFQHARIAALTERLSLDYEWNFGLSFGWKPFDERTNPFNTVVGSKINAYINLGLMLNWRFAPRWSLTAGVGLTHFSNGNTRYPNGGVNLIGGRVGLMRTFGRDAADDRRAAVRRSDLFRPYVSYDVILYGALRKKGFLQESRAYLIPGSFAVAGLNFTPMYNFSRFFRAGLSLDAQYDESANLKDHIANDYPLADELKFHRPPFKEQFAVGVSIRCEVVMPIFSINLGIGKNLIGRGDDTNSFYQVFALKADVARNVFLHVGYQLYKFRNPNNLMLGVGYRFNGR
>NZ_AP019739.1|WP_141418111.1|106701_107661_+|hypothetical-protein
MRKLFSRYALSAIVAPLLAVGCNDGVFIDDFLPEAPSVTVGPDDTSATIRFEAGNWDILSVEGPTTSLSGDIYDAEGNLLYGNHLLYGDGLLRMTYDDGLLDFGIERNDYRTLRITLGESLRDEPWETRILVGNDYESETVSVTFAPTEKYRVDSVVYRWDEFESWDNSIELQDAFTIDNTASSEPASVVVSPFRNAKRTVRFWPDDFNDRREEIFGVPLPEIVIPDMADGTPVVAESSARFARNDQQLPLSFPDDEQVTVTAKPHERLNVEVYLSLEQFRVPYTVYASGPAGRQRTFTGTLHSSLPYDYLILKPKTDE
>NZ_AP019739.1|WP_141418110.1|105490_106570_+|radical-SAM-protein
MDGRHLSLRKRLGLELYRRLHREAVERHELRTLFWECTLRCNLRCGHCGSDCTASPDCQDMPAEDFFRVLDRQITPRVDPHRVMVVLSGGEVLVRSDLERIGRALYDREYPWGMVTNGMALTPQRFDGLLAAGLHSMTVSIDGFEAEHNRLRRHPLSFARAAEAVRMAAAEPSIAFDAVTCVTPALVPRLDEFKEYLLSLGLRSWRLFAIFPAGRAAEDPALQLSDGQFRALMEFVRRTRREGRIACSYACEGFLGGYEMEARDHFYHCDAGVSVASIRVDGAISGCTSVRADYAQGNIYRDDFWQVWTERFEPFRRREWMRRGACADCAAWRYCEGGPMHLRDADGGMMHCSYRRLCR
>NZ_AP019739.1|WP_141418109.1|105057_105489_+|hypothetical-protein
MNKLWMLLLSLLGFAGCDEPQEDMYGTPYAEYTVKGRVTDAAGTPIAGIEVRRPSWGSDPSAVRTDTRGAYTFEADGNVLYMPPVLTFTDTDGPAGGGDFAGKEVEVAFAESDRTGPGEGSWMYGRFERSGVDVVLAEKTGEE
>NZ_AP019739.1|WP_162851472.1|103494_104979_-|(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MDLTQYRRRATHEVRIGACTIGGTHPVAVQSMTNTDTRDTAACVAQIERIARAGAPIVRLTAQGVREAENLRDITERLRADGNTTALVADIHFLPEAAAVAAQYVDKVRINPGNYRLDRGELEALVARCRERGVALRIGVNHGSLSKRIFDEWGDTPEGMVAAAMEFLHVCRREAFDQVVVSMKSSNTRVMVAAYRLLVEAMEREGMTYPIHLGVTEAGNGLEGRIKSAVGIGALLADGIGDTIRVSLTEAPENEIPVARLLADHFRERPGRFEVKHPERYSPTVYRRRSGVQTPVVRDEITPAFRLLESTSQNPTAELRAAILSLDGDEPAAVVRRYDDTDLTTLAVKAAADLGPLFLDGLADGIRILDDRFTEAQLRDVELMILQAARVRFSHTEYIACPSCGRTLYDIEGTLAQIKARTSHLKNLKIGVMGCIVNGPGEMADADYGYVGAAPGRITLYKGRTVVERNIPQEEALDRLIALIRENGDWQEPE
>NZ_AP019739.1|WP_019130492.1|102363_103485_+|acyltransferase
MPQTSLPSAAYADSKPHYDILDGLRGVAALLVVVFHLCEAHATSHFDQLLNHGYLAVDFFFALSGFVIGYAYDDRWGRMTVGGFFKRRLIRLQPMVVLGMAVGAALFYFQDCDMWPVHAVPVWKMLAVMLVGMTLLPVPVSMDVRGWQEMHPLNGPGWSLFYEYCANILYALVVRRFPKWLLGVLVAVSGAALIRFALTSPSGDIIGGWSLTAEQLGVGFTRMMYPFFGGLLLSRLVRPGHVRRAFWWCSLGLVALLAVPRVGGTEHLWQNGLYDALVVVVLFPLIVWTGASGTVTGRSARVCEFLGDISYPIYITHYPLVYTYTAWVRNHGLTLGEAWPAAAGTVVVSVLLAYAALKWYDEPVRRWLRREFM
>NZ_AP019739.1|WP_141418107.1|101641_102241_-|WbqC-family-protein
MTILPAAYLPSIEYCARWAQGPCVVDGGEHFVKRSERNRTHILTAGGVLALTVQAVRANRPRTPMRDVRIDYSKRWQHQHWTALVSAYKASPYFDHYAPRFEPFYTRRYEFLFDYNLRLMETIAELLGLPMPAVSEAYLTADEGDLDLRPKRKEGADFASPPYIQVFSDRLPFTPNLSIADLLFCEGPQSPALLKQCRL
>NZ_AP019739.1|WP_141418106.1|99678_101718_+|beta-galactosidase
MKRYLLLISMLAAFVAESAAREVYRLNDDWTFYFRSENSADDARNITLPHTWNLDALAGNSEYQRTTGNYMRRLYIPADWASKRLFLRFDGVQTVADVFVNGYHVGEHRGGFTAFTFEITGRVKFGAENRLLVVVSNTFQNDVLPTSTEQNVYGGIYRDVDLILTDRVAVSPTVWGTDGLFVEQVSVDDDAVEGRAAVYVSAPKDCQGMITLTVRDPDGYVVVEKTQKNNRPAGEPVTIPFTVDAPRLWSPAAPNLYTVTARVACDSLSDEVTVRTGFRRIAASGRGLLVNGDTVRLHGVALYHDRASVANAFTAADYDEDLAFVHDVGANAVHSVSGPHDQYLYDRLDERGLMAWIDLPLMRSPYLGDVFYFPTERFRANGREQLREIVAQNFNHPSVVMWGIFSLVWQRGDDVTPYIRELHTALKRVDPSRPTVALSNQDGELNTITDLIALKQNVGWMRGTTDDVGYWCETLHKSWGNLLAAPCYGVPGYPSQQDDLLGRPTPGTHWLPERWQTRFHEEYARRIVSDPAFWGEWVNAMFDFGTARGANDRYACGMVTLDRRQKKDIYYLYRTLWNRREPTLYIAERRWRVRPSAEQRIKVYSSGEDPVLLVNGDSVALTKYAEGQFRADCKLLPGENRIEARCGELRDSVALRVGTALKARDFEALRKTKGLRSKD
>NZ_AP019739.1|WP_026074911.1|113246_114044_+|DUF3108-domain-containing-protein
MKRILILFLLTGGIFSAAGQIYVPGEELFYRVSYRAKLVPNTEVATVVVRTSEVELDGQTVYNVFGQGKTLASFRWFFSLDDRYNIWVDTATLRTVRFTSDIHEGGYTFRSRFDYDWPARRVATRWQRRTLPENRKEMALTDVSMDAVSLFFNMRSADAASFRVGEQRVLQMVLEDTIRHLRYRFEGREVKKIRNMGKFNTLKFACQIGTSESFSFTDGSEFFIWLSDDENKIPLHLESPIRVGSVNAYITGYKGLKYPLTSKIR
>NZ_AP019739.1|WP_141418114.1|114046_114829_+|alpha/beta-hydrolase-fold-domain-containing-protein
MKLTQIDLAEGRGGSQREVSASEAVARAEEACGGTLLLFEPDGVPRAAVAICPGGGFGKVNTEHEGVAFAEWFVAHGIAAGVVKYRLPEGDPALPQQDVERAAELLHNRFDGVKTGVLGASIGGYLAACAALAQPAARRPDFQLLFYPVVSMEEEFAHRPSMLRMFGRELHGLEAKRRSPLYRIDRAAPPAFLAAAADDGAVTPLGACRYAECLLAAGAGAALHLYPSGGHGFGLRREFAWREALVGELRMWLDATIGTV
>NZ_AP019739.1|WP_019130482.1|114880_115816_+|hypothetical-protein
MEENKDYNPSQYEDDDRMEAPKSAKSIRGYQTIIVILAVILAALSILYFNIHRQQQEEYDLLLVDRDSIKSNLSHLMEDFDNLQISNDSISQSLGLERSRADSLMERLTKERSWSYAKIKKYEKEIGTMRTIMRGYLRQIDSLNTLNKNLIKENVSYRKEISSANLRAEVAEEKASELSTKVRQGAVIRARGIRLVPLNARDKEVSRVKNASRLRVEFTLAGNDLAEPGERTVYVRITSPDGYVQSNASAATFEFEGERLTYTASRDVDYQNEDLAVGVYYNDGAGFTAGTYRVEVYADGRLAGQSDIVLR
>NZ_AP019739.1|WP_019130481.1|115958_116462_-|hypothetical-protein
MKKIFAILIALSALSNFSCKEKEEEYTEGGLVFGGIYMLDGQQLVETDGYILELPAEQNTVELRIVSKGVQEFGIGGYPMSGLGEYKVEGFTIKVTPDPASEKLEIYDYIDVEYKGEQHRIPRYLQTLHLGADTNTGQQKEIRIRFITNIPNYWMEWSQLTVRQAGR
>NZ_AP019739.1|WP_019130480.1|116475_116958_-|hypothetical-protein
MKKYIIPLIALTALTGWGCEEEMVGGDWDYKDAMILVGQELIYAHNHTVELPAQQCSIDLQIVSEGISGQSSIDADHFGQNLPDAFSLTLLTPRHEAEIYDYIVDSWGVEHKEWPRYMQTIRITATENRFIIPRIMRCRLWTESPQVGAADITIRQAGAK
>NZ_AP019739.1|WP_141418115.1|116977_118375_-|hypothetical-protein
MKPNKTLFGAFVISVTLIIGACQQTELSDSAPTPSFPAPAAEFVADDSDLSAGDAAAVARIFRNGNRPTRAGSDAVVRNVVTIRDAAGRPAIYAVNLQEGYLLISATKRCYPILAQIDRGTFTLDREPSGLDVVLQEMTETIEAARDSAAVFDCRSAWLPYEERTRPERVQTRMTDDEFYDIQNEWYGKWFAEGADTYRLASKPDEMPEDAYQRFCETAIGDDAWVDTPYNCMESGVITVKYHESGTKKGPFLTTKWGQRNGYNALFENKDQPLGCVTIAVGQLMRYYQHPAYFGWSDMPDETSNTTLTSFLTQLHGELRVTDGGSSNIDHAKRVLESYGYSCSKRSHNASTVYTMLNSNLPVYTQGQDKPRDVGHAWVVDGSNSITAYTEYKLYALNNGLPRPWYVELDSERVYHSQNVFFHMNWGQYGLYNGWFLDTKISFKNNKNEICNYSSNRKDLLITDF
>NZ_AP019739.1|WP_141418116.1|118514_119381_-|HAD-IIA-family-hydrolase
MATIDSYRSPFPHEELLERARRIRHVALDMDGTIYMGMSLFPWTKRFLSDLTEMGIGYSFLTNNPSKSIADYLHKLETLGIEATREEMYTTALATIDYIRSHYPTAKRLFLLGTPSMISEFEAAGFESTADSAEDVPDVVVAAFDMTLTYPRLCRAAWWASQGIPYIATNPDRVCPTDQPVVLVDCGSICKCLEHATGRTPDIVLGKPDPNMLTGIKERFGLRADEIAMVGDRIYTDVAMARNAGALGVLVLSGETTEEVASAADPQPDVTALSLKEFGELLKEAHGK
>NZ_AP019739.1|WP_141419593.1|119696_121241_-|hypothetical-protein
MLFAAGTLFAGCSDDDTQAPLNTPIQEGNNLYGVVTDPNGAPVGGIVVSDGFSCVATDANGVYQMPRHADAFHVFYRIPADREIPMSEGRPCFWQRLSKTQERYDFVLMPQQAVETDFKLVCIADPQVQKDTDLARFKEESVPDIRAHVSTLEGPVYGITLGDIIFNEKAKDVTNQMMPPIALAMRESEIGLKLFQVMGNHDNCMTPTVTDESSNFDLAGRRNFEYKFGPCDYSFDRGNAHIVAMDDVLLTDEKHNPSDYEGGFTDAQVEWLRQDLSLVPKEKLVIFCVHIPLRNATSFNRETVRNLLKEFDNVHIMAGHTHYAQNYIDGDVYEHIHGAVCGAWWKSTINVDGTPNGYGVYDISGSKIENWYYKPTRLSKDFQIRMYRGETTFAGGYKFTYTASDEIVANIWNSDDRNWKVEVYENGNKTGEMTREKSLDAWGAGYHVGVLSANPDSHGKTTYDHFYHYKLKDAKAAVEIRATDCFGKVYTQNVFTTAAETDYPMVDNYPAVAE
>NZ_AP019739.1|WP_141418117.1|121344_123144_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKRIIYAALACLTFASCEDFLDKQPIEQIGTDEYFKDEASLEKYTNGFLNSYTPSSGDVTRGDGNCDIIEVKQTSSYLYQPVWNSSLQGGWSNSTWNFVYYINTFLERMHEAQGVSEAAFAHYEGTARFWRAWNYFELVKTFGGVPWYDHVVRSDSEEDLYKPRDSREYVMERVLEDLNYACEHCYTSEAWVDNQKINRYIALAIKSRICLFEGTYRKYHRVDPSTGKAWDPEYNKDNKWLREAADACEELMEAGVYSLVNSPADVATQYRSLFTSPSVLKQEVMWAREYNDEKNVRHDVTWYFTSGSMGQGWSLDADFVYTYLNRDGSRFTDRADYKSTTYAEQFENRDYRLQQTVISPEYRKLVGGTSKLFAPDLSVSYTGYQVIKFNIDDDSYEASGICWNCLPILRYAEVLLNYAEAKAELGEFDDAVWDKTIKPLRERAGVDGTRPTKIDEYLQNAYYSTDDGNPKITDCDILEIRRERAIELLLEGRRYDDLMRWHLGGLLNKQWYGIYIGEVDKAYDLNNDGVNDVCVTDKAGSEPGVKYIVRNSERALEDGASGRLVYNLQRYFNEQRYVHPIPKTALDKNPDLGQNVAWK
>NZ_AP019739.1|WP_141418118.1|123157_126457_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MSYSERSPHAREPLPAYGILRGRTCFDCPDNQCLRTGGGNITGTVKDKSGNPIIGAAVTIPNTARGTSTDIDGRYTIKASANESLNFSYIGYQSQLIQINNRTTIDVVLTEDNTSLEEVVVVGYGVQKKRDIVGAVEQISSKDIADRIGSYQNVSRSLQGAIPGLTVTFSDGKPTRGASFQVRGANSIGAGGSALILVDGVETDITTVNSEDIESISVLKDASSTAVYGSRGTFGVILITTKRPEKGQMKITYNGSYNFYKRTVTPELVDNGYDWTTSYLEAYTNSYATDPTNINNVFRFSRAWYSELERRNSDPSYEKWRINPADNRYEYFGNTNWYKIFYKDYTTGHQHNLSITGGTDKASYYVSGRFFHQDGIYNAGDERYNQYNVLAKGTVQATKWLRVENTTSFMSRFSHQPTLTTGGQSFTVTPTRMMNHQGFPMTLEKNPDGTWTDAAVYMGWAGFVEGNTWREDDKFDLNNKTKFTLDFIKDVLVGEIDVSYYRNHTERHMLAVPYTYYTGPESSGERPATSWYEERYYNRERVASNAVLTWTPKLGENHWLKLMGGWNIENMDYTSTLGQNTGVIDPEHPSLSLTDGELPKAQGNGSYSASLVGTFFRVNYGYKGKYLVEVSGRYDGNSKFPSNQRWGFFPSASVGWRISEEPFMAGAKSWLDNLKIRASFGSTGNGQVDNYLFLSKIAIKKNLGFLTGDSPLIYADKPSLIPDGLTWETVSTYDLGLDWEMLNGRLSIVADIYRKNTTDMYVVGPELPAVFGNSAPKGNYADMRTDGWEASISWRDNFKLGGKDFSYNLKFAIWDNVTKVTKYMATTNTLPTNYATNYYEGMTLGELWGYTCNGLFQSNEEAQTYADYSKFAQNKIVWQKGDPKYEDLNGDGRIDNGSNRLEDHGDLSIIGNTSPRYCYSLAAGARWNGIGLSMVWQGVGRRDWYPAKESGYFWGQYGRPYSIALPWHNDRYTDANQNTDAYWPRLIGYTAQGANAILSQPNTRYLQKARYVRLKNLTIDYTFPKQMLTKIGIQNLRIYLSGENLFTITPLKKYAKNYDPENIYAGDSDFSSTRGGDGSGDGDGYPVMRSYSIGLSITF

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Crispr_ID: NZ_AP019739_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_3

308395-308505

Orphan

Consensus_repeat	Method
GTCTCGGCATAATCGAACATAAATGTTTGCTTCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_3

>merge|NZ_AP019739|3|308395-308505|CRISPRCasFinder
GTCTCGGCATAATCGAACATAAATGTTTGCTTCTGCCTCGACTTTTCGTACTTTGACTGACGTCTTAGATACTCTGTCTCGGCATAATCAAACATAAATGTTTGCTTCTGC

>NZ_AP019739|3|2|308395-308505|CRISPRCasFinder
GTCTCGGCATAATCGAACATAAATGTTTGCTTCTGC	CTCGACTTTTCGTACTTTGACTGACGTCTTAGATACTCT
GTCTCGGCATAATCAAACATAAATGTTTGCTTCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141418201.1\|315092_316439_-\|sodium-dependent-transporter	unknown	unknown	gnl\|CDD\|271367
NZ_AP019739.1\|WP_141418202.1\|318391_320299_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|237874
NZ_AP019739.1\|WP_141412715.1\|317065_318358_-\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NZ_AP019739.1\|WP_141418199.1\|313241_313838_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_AP019739.1\|WP_019130334.1\|302377_303982_+\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|236471
NZ_AP019739.1\|WP_141419599.1\|310525_312334_+\|protein-BatD	unknown	unknown	gnl\|CDD\|379280
NZ_AP019739.1\|WP_141418192.1\|295954_296518_+\|phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|235544
NZ_AP019739.1\|WP_141418197.1\|308754_310368_+\|fumarate-hydratase	unknown	unknown	gnl\|CDD\|237955
NZ_AP019739.1\|WP_141418193.1\|296528_298058_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234854
NZ_AP019739.1\|WP_141412708.1\|300472_300865_-\|DUF2721-domain-containing-protein	unknown	unknown	gnl\|CDD\|378544
NZ_AP019739.1\|WP_141418196.1\|305670_307047_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_AP019739.1\|WP_019130332.1\|304724_305612_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378964
NZ_AP019739.1\|WP_019130330.1\|307213_308212_-\|class-II-fructose-1,6-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|180829
NZ_AP019739.1\|WP_019130318.1\|320366_321272_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_162502150.1\|301184_302015_+\|phosphodiester-glycosidase-family-protein	unknown	unknown	gnl\|CDD\|378342
NZ_AP019739.1\|WP_019130322.1\|316647_317001_-\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_AP019739.1\|WP_141418194.1\|298205_299456_+\|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|234856
NZ_AP019739.1\|WP_141418200.1\|313966_314779_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418198.1\|312340_313183_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_AP019739.1\|WP_026074877.1\|299460_300318_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	unknown	unknown	gnl\|CDD\|184560

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141418201.1\|315092_316439_-\|sodium-dependent-transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	0
NZ_AP019739.1\|WP_141418202.1\|318391_320299_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|237874	PRK14971, PRK14971, DNA polymerase III subunit gamma/tau.	0
NZ_AP019739.1\|WP_141418199.1\|313241_313838_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	9.28949e-96
NZ_AP019739.1\|WP_019130334.1\|302377_303982_+\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	0
NZ_AP019739.1\|WP_141419599.1\|310525_312334_+\|protein-BatD	gnl\|CDD\|379280	pfam13584, BatD, Oxygen tolerance. This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.	1.33324e-172
NZ_AP019739.1\|WP_141418192.1\|295954_296518_+\|phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|235544	PRK05647, purN, phosphoribosylglycinamide formyltransferase; Reviewed.	1.1427e-90
NZ_AP019739.1\|WP_141418197.1\|308754_310368_+\|fumarate-hydratase	gnl\|CDD\|237955	PRK15389, PRK15389, fumarate hydratase; Provisional.	0
NZ_AP019739.1\|WP_141418193.1\|296528_298058_+\|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NZ_AP019739.1\|WP_141412708.1\|300472_300865_-\|DUF2721-domain-containing-protein	gnl\|CDD\|378544	pfam11026, DUF2721, Protein of unknown function (DUF2721). This family is conserved in bacteria. The function is not known.	2.82952e-30
NZ_AP019739.1\|WP_141418196.1\|305670_307047_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	4.14671e-133
NZ_AP019739.1\|WP_019130332.1\|304724_305612_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	1.94412e-21
NZ_AP019739.1\|WP_019130330.1\|307213_308212_-\|class-II-fructose-1,6-bisphosphate-aldolase	gnl\|CDD\|180829	PRK07084, PRK07084, class II fructose-1,6-bisphosphate aldolase.	0
NZ_AP019739.1\|WP_162502150.1\|301184_302015_+\|phosphodiester-glycosidase-family-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	2.98543e-40
NZ_AP019739.1\|WP_019130322.1\|316647_317001_-\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	3.39627e-30
NZ_AP019739.1\|WP_141418194.1\|298205_299456_+\|phosphoribosylamine--glycine-ligase	gnl\|CDD\|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_AP019739.1\|WP_141412715.1\|317065_318358_-\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_AP019739.1\|WP_141418198.1\|312340_313183_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.36238e-11
NZ_AP019739.1\|WP_026074877.1\|299460_300318_+\|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD	gnl\|CDD\|184560	PRK14190, PRK14190, bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional.	6.14027e-142

>NZ_AP019739.1|WP_019130330.1|307213_308212_-|class-II-fructose-1,6-bisphosphate-aldolase
MVSYKELGLVNTREMFAKAIKGGYAIPAFNFNNMEQLQAIISACVEANSPVILQVSAGARKYANQTLLRYMAQGAVEYAKELNGGKGIPITLHLDHGNSFELCKSCIDMGFSSVMIDGSSLPYDENVALTKKVVEYAHQHDVTVEGELGVLAGVEDEVASEVAHYTKPEEVIDFVTKTGVDSLAISIGTSHGANKFKPEQCTRNAEGILVPPELRFDILAEIEKKLPGFPIVLHGASSVPQEYVKIINTHGGKLKDAVGIPEEQLRKAAKSAVCKINIDSDGRLAMTAAVRKVFIDNPAEFDPRKYLGPARDELKKLYMHKCENVLGSAGKA
>NZ_AP019739.1|WP_141418196.1|305670_307047_-|FAD-dependent-oxidoreductase
MMSEKHSIHCPARDIPVRAEVDVLVVGGGPAGIMAAEAAAGDGLRVMLVESRGFLGGNLTIGLPVLGFLGHKGTQIIKGLPQNFIDRLRARGAASEHRPCALHMSLTIIDPEEAKRTALEIMEEKGVEVLLYVFCTDVVKEGDDVKGVIIESKAGREAILARTVIDCTGDGDVAFRAGVECRKGDAEGGMQPPTLMFCMKGVDVQRLRDAIVQHPDVYDMDTMPAEQFRTGKFITVGLRNQIEQARAKGIHIPVARTILITGLADDEIWVNMTRVNGVDSTRPESYTHGEIEGRKQVYEVERYLREFVPGFAGAHLEKIAPFMGIRESRVIVGKYVLTAEDILEDRRFDDAIAVAGYPVDIHHAKGGDCTLYWCDDCYDIPYRTLIPAHVGNLLVAGRCSSMNHEAMASTRVMSTCMALGEAAGRAARLALKAGVQPADLDVEALRAELRATGAYLRD
>NZ_AP019739.1|WP_019130332.1|304724_305612_+|AraC-family-transcriptional-regulator
MVKPNNLRKVSIARLKQEMQDTVFLSDDLAITTIDYLRNPTSEIPVSLDGFAAMIMMSGSAVLSIDTETYEVRPNMLVFFRPGSIIRTIRCSSDATAYLVACSKAFVSDIQVDISASLPIHMRFGRKPCLQVTERDVAEIRQFFQLIKTVIQSDKERYRKEIIHTLFTAVFYLITELNQREQSSEQKQGRCEVLFDQFMQLLGEYNKRERNVSFYARQLNITPKYLSSVVKEVSGKTAAKWIDESVILEAKSLLKYSGMSIQEIAYHLNFSTQSFFGKYFKQHTGTSPSRYKRKG
>NZ_AP019739.1|WP_019130334.1|302377_303982_+|phosphoenolpyruvate-carboxykinase-(ATP)
MDKMDLKKYGITGVTEIVYNPSYDELFREETKKGLRGFDKGVVTDMGAVNVMTGVYTGRSPKDKFFVMDETTKDTIWWTSPEYKNDNKPVTKAAWKELKKLAGQELSGKKLYVVDTFCGANENTRLKIRFIMEVAWQAHFVKNMFIRPTDAELEQYGEPDFVVLNASKAKVKNYKKLGLNSETAVVFNLTEKMQVILNTWYGGEMKKGMFSYMNYLLPLKGIASMHCSANTNEKGETAIFFGLSGTGKTTLSTDPKRQLIGDDEHGWDDDGVFNFEGGCYAKVINLSKENEPDIWNAIRRNALLENVTVGPKGKIDFADKSVTENTRVSYPIFHIENIVKPVSKAPAAKKVIFLSADAFGVLPPVSILTPEQTKYYFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTKYGEELVKRMKKSGAKAYLVNTGWNGTGKRISIKDTRGIIDAILDGSIDKAKTKKLPIFDFEIPTALPGVDPAILDPRDTYKSASEWDVKAKDLAERFIKNFVKFTGNDEGKSLVAAGPKL
>NZ_AP019739.1|WP_162502150.1|301184_302015_+|phosphodiester-glycosidase-family-protein
MKRVLGWLLVCLPVAAGAQSVQDSLAIAAIRWDTCCVRPHLVAVQAQLELFGAPQAISMVRYDAGRYRTRIVQPDSLTLTSVLAEAEGAVAAVNAGYFNVKTLVPSTFVRVGGRTVAATEAREEFRVNGVVTIKGRRVRIEPYVPADDARLARRYRDALAAGPLLLCRGEALSYADREGGFWGRHPRSVVGVTRRGEAVMIVVDGRFPGQAAGMTIGELIYLVRQLGLYSALNLDGGGSSTLWCEEAGVVNRPSDNRRFDHEGERRVTNCIAVVAE
>NZ_AP019739.1|WP_141412708.1|300472_300865_-|DUF2721-domain-containing-protein
MEELTLTVPALLFPAISLILLAYTNRFLSYAQLIRTLKAQYLQHRSDLTAAQIDNLRRRLYLTRAMQILGIASLFLCVVTMFLLYIGLQLVAAYVFGAGLLALIGSLGVSIREIQISVRALEIYLNDMEH
>NZ_AP019739.1|WP_026074877.1|299460_300318_+|bifunctional-methylenetetrahydrofolate-dehydrogenase/methenyltetrahydrofolate-cyclohydrolase-FolD
MATIISGKELSASMKAEMAAAVKEFPAKYGRVPHLVVVLVGDDPASVSYVTGKAKASAEVGIRNTTIRRPAETGEAELLALIGELNADDGVDGILVQLPLPKHIDEDRVIAAIRREKDVDGFHPLNVANLWLKQPCTLPCTPKGIIRMLQRAGVEIAGKRAVVIGRSNIVGLPVAKLLLDANATVTIAHSRTRNLPEVTREADILVVAIGRPRFVTADMVRPGAVVIDVGVNRDPGTGKLCGDVDYAAVEPLASVITPVPGGVGPMTIACLMENTVECFLRKMER
>NZ_AP019739.1|WP_141418194.1|298205_299456_+|phosphoribosylamine--glycine-ligase
MKVLVVGGGGREHAIVDALTRSGRIDTIYCAPGNAGIAAQAECVPIRETEVEALRDFALAHNVTLTVVGPEAALAAGIVDCFRAAGLRIFGPTKAAARIESSKEFAKELMAKYGIPTAGFRAFTAYEEARDYVASRPLPAVLKYDGLAAGKGVVIAQTMEEADAALRDMLLDDKFGHGKVVVEDWLEGPEFSFMCFVDRRRVYPMALAQDHKRAYDGDEGPNTGGMGAYSPLPFVTGEDERYALERIMQPVADAMCAEGCPFTGVLYGGLMKTRDGIKVIEFNARFGDPETEVVLPRLKSDIVEIFSAVADGWELEHPLEWHDFSTVGVVLASKGYPGSYAKGAVIEGLDEVDGAVYHMGTASKEGRIVTAGGRVAIVVCAAPTLGEALEKCNREVGKVRCDNLFHRTDIGRKAIK
>NZ_AP019739.1|WP_141418193.1|296528_298058_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MRALISVSDKTGVVDFAKNLKALGWEVIATGGTMKLLRESGVEVLNISDVTGFPEICDGRVKTLHPAVHGGLLARRDVEEHVEALRANGIEFIDLVCVNLYPFRQTIAKEGVTLAEAIENIDIGGPSMLRSAAKNFRDVTVVCDPADYAAILDEMRAEGNTSVETRLRLSAKAYTHTAEYDSMIATYMRAQAGLPEKLFLDFDLVQSLRYGENPHQTAKFYRSAEKVPFSLAHARQLNGKELSYNNIQDANAALNIVREFDEPFCVGLKHMNPCGAAVGRDVVEAWTKAYEADKVSIFGGIVAVNREVTREAAERMKPIFLEIIMAPKFSEGALEVLCTKKNLRLLEVDMTRSDVHPMQYVSVNGGLLAQELDVETKRVEASMTVTKARPDAAQLRDLEFAWRIVKHVKSNAIVVVKGGQTLGVGAGQMNRIGSAEIALKEAQAKGATEGLVMASDGFFPFDDCVTLAAANGVAAIVQPGGSVRDEDSIRKADETGVAMLFTGMRHFKH
>NZ_AP019739.1|WP_141418192.1|295954_296518_+|phosphoribosylglycinamide-formyltransferase
MKRIAVFASGEGSNFEAIAAACERGAIAAEVALVVCDRPGARVTERAAARGIACFAFAPKEYASKADYEREIVARLDAAGVDLVCLAGYMRILSEVLLGAYGGRIVNIHPSLLPAFKGAHAIEEAVAYGVKVYGVTIHWVDATLDGGRIIAQRAFAYDGDDVHEVERRVHEVEHELYVETIDKLVKA
>NZ_AP019739.1|WP_141418197.1|308754_310368_+|fumarate-hydratase
MPEFIYQEPFPVGADTTEYRLLTKDYVKVVECDGRKILKVDPKGLEELSKAAYSDVSFYLRASHLQKLRNILEDSEASDNDRFVAYTMLLNQCVAAEGELPTCQDTGTAICIGHKGEDVYTGADDAEHIARGVYETYKERNLRYSQVVPFTMTDEKNSGTNLPAQIDIYGGHPGMEYEFLFITKGGGSANKTFLYQQTKALLNEKTLTEFIRTHIKDLGTSACPPYHLAICIGGTSAEMCLSTVKKASAGYLDALPTSGNEGGRCFRDLEWEEKVLKICQESGVGAQFGGKYLVHDVRVIRAPRHAASCPVAIGVSCSADRNIKAKITPEGIFLEQLEKNPARFLPKQAPAMSPAVDIDLDEGMDKVREILTKYPIKTRLNLRGTLIVARDIAHARIKQMLDEGKPMPDYFKKHPVYYAGPAKTPEGMASGSFGPTTAGRMDPYVDLFQSHGGSMVMVAKGNRSQAVTDACRKHGGFYLGSIGGPAAILAKNSIKSVEVVDFPELGMEAVRKIYVEDFPAFVIVDDKGNDFFADFKH
>NZ_AP019739.1|WP_141419599.1|310525_312334_+|protein-BatD
MLTLLTVFGATVASADEKVSFEVKAPMVVAKGEAVRVEFSLNASPDEGSFTAPSFEGFDVIAGPAFSQGSSIQIVNGQMTRSSNYTITYVLLPQQEGNFTIGAASVRVGKSQYKTKALPIEVVEETPESSGGQQAVQGGQSADDVQQVSKDDILLRMILSRTTAFKGEPIRATLKLYYRVNLRGDNGSKFPSFNGFWAQEIEQDAQPQRERYNGKVYETQVIKEYLLYPQQSGELTVEPAELNVVAQVLVQSANPDPFFGGGHEVYDVRRSLRTAPVKVTVRDLPAGAPASFSGAVGKFTMASDVPSTELAANSAATYTIKISGTGNLSFVQAPKLMLPSSFEQYNVKTTESMKTTSAGTTGYRQFEYPFIARAEGEYEIAPVEFTYFDPAKKQYITLSTARLPINVAPDAGGGAAAQVVTGLSKEDVKLLGQDIRFIKLGRGNLHLQGRPFMGGTLYFVLLAAIVGLFAAAYVALRKRIRDRQNAVLMRGKRANKVAVQRFRAAAKFMQEENRHAFYEEMLRALWGYMSDKFNIPVANLTKENVREELNKRGVSQELSQSFSEIISQCDEAQYSPLAGARMSDVYNAGVDFISKLESVIKK
>NZ_AP019739.1|WP_141418198.1|312340_313183_+|tetratricopeptide-repeat-protein
MRTSRIFWSLLLLFLSLTAAARAQGDRDSLAAATTDPLTVQTAGGNSLAAVEQVWDAANTAYINSDYHRAIDAYRQLILRGYASDKLYYNLANAYFKVGRYGKAILYYNRALRLAPGDADIRYNLDVANTFTKDKIAVVPEFFLKGWVRSVRMSLGCTAWSVVSLAALALLFALVLLYLLAGRLAWRKAGFYGTLAMLLVFVASTSFAVTERRELLDSTEAVVMSSSVSVKSSPDKASTDLFVLHEGTKVRTVSELGDWREIVIADGKKGWVEARTIETI
>NZ_AP019739.1|WP_141418199.1|313241_313838_+|recombination-protein-RecR
MSQLLTDVVEELSKLPGIGRRTALRLAMHLLRMEPSIVAGMTRSIDRFRREIRYCRECNNLSDTDVCPICEDPKRDRSTICVVEQVADVLSIEHTQQYRGLYHVLGGVISPMQGIAPSDLKIDLLVERIRRGGVGEVILAISTSVEGETTLFYLMNRLREFSDLKVTSIARGIGFGDELEYVDELTLTHALLNRRAVE
>NZ_AP019739.1|WP_141418200.1|313966_314779_-|hypothetical-protein
MKKLVLLIFTVCMGGGIAASAQEVSQQKLDSLNQALSDISARVKETEAAESNRAIWKDRSKYFNLNYVNQKLSPDIDGWDKLGGGELKSDFGAAIVWGKTYYLHKKPLAGMIKFGIDWSWMDLNYAQYKLETYDYDTDELYSEKAHQLEYGMQIGPSVTINPVHHLKVSAYFRVTPSYSMMYLNDEFYHHYATFCNTGFAVAWKVLSVGCEWRWGKASYDGLGLNLDDLEGDYSDGDFSGDIPSADDVLTDLQDLKLKTKSFRVYFSFRF
>NZ_AP019739.1|WP_141418201.1|315092_316439_-|sodium-dependent-transporter
MKTTHRATFGGRLSAVLVTAGSAVGLGNIWRFPYVAGENGGGAFLLIYILSVLLLGVPIMLSEFAIGRNTHRNAVGAYRTLSSRWSILGYNSILAPLLIMGFYLVVSGWTLEYMIHSLTGEFTRISTPEAYESLFNAFTQNPWKPLLYTVVFTLLTHGVIALGVQKGIERSARIMMPLLLLILVVLAVHSILLPGGTEGVKFLFAPDFSKVTPSTVLTALGQAFFSLSIGLGCLVTYASYFKNDTNITHTALQVAFIDTLVAVLAGLVIFPAVFSVGIEPTAGPSLVFVTLPAIFNTLPLSMVWSTIFFLLLVIAALTSTISLHEVLTVYVQEEWRLSRRAAAWIVTGACIALGAAASLSLGAWQWLQLGGKSFFDLLDFVTANIMLPAGGFFICIFTGWVLDRRFMPAELTNHGALRLHLWPLLGMLLRWVCPVVILLIFLDNLGVL
>NZ_AP019739.1|WP_019130322.1|316647_317001_-|dihydroneopterin-aldolase
MLYTIDLQGMEFHAFHGCYDLEQRVGNRFEVTLSITTELGGIAAHDAVEEAVNYLTVYEIVRERMAVTQRTIERVATNIIEALHARFPAVRHVRCTVAKLAPPLGGKIARVSVTLEG
>NZ_AP019739.1|WP_141412715.1|317065_318358_-|tyrosine--tRNA-ligase
MAIKNFIEELEWRGMIHTIMPGAKEQLEKEMTTAYLGIDPTADSLHIGHLVGVMILKHFQMCGHRPIALVGGATGMIGDPSGKSQERNLLDEETLRRNQEAIKRQLAKLIDFDSDAPNAALMVNNYDWMKGIGFLDFIRDIGKLITVNYMMAKDSVKKRFNGEGDGMSFTEFSYQLVQGFDFMHLYEKYGCKVQLGGSDQWGNITTGTELIRRKLGAEAYAITCPLITKADGTKFGKTESGNVWLDPRYTSPYKFYQFWLNVSDDDAKRYIKIFTLLDRATIDALVAEHDAAPHLRTLQKRLAEEITVMIHSREEYEKAVEASQILFGGATSEALRRLDEQTLLQVFEGVPQFTVARAELGLPFVDLCAAATQIFPSKGECRKMVQGGGVALNKEKVADAMRPVTEADLIAGKYLLVQRGKKNYYLVTVE
>NZ_AP019739.1|WP_141418202.1|318391_320299_-|DNA-polymerase-III-subunit-gamma/tau
MENFIVSARKYRPATFASVVGQKHITSTLKNAIERGQLAHAYLFCGPRGVGKTTCARIFAKAINCLHPEGAEACNDCESCRSFNENRSLNIHELDAASNNSVDDIRNLIEQVRILPQGGRYSVFIIDEVHMLSAAAFNAFLKTLEEPPAHAVFILATTEKHKILPTILSRCQIYDFNRIKVEDSVEYLKYIAGQEGVGYDEESLNLIAQKADGGMRDALSMFDKAVSFCGARLEYKSVAQTLNVLDYDTYFNVTDMLLGGDYLSALRLFDEVLAKGFSGQTFMAGLAQHMRDLLVARDAASVSLIELTGTLLERYRAQAGRCTIEFLFGAISLLTEADGRIRQSSNQRLLVELGLMKIAGLGQKKNDGVALGTSYPLPPLTGQNAPAANPRHTTSGPSAAPTSATTAATATGTPSTATPAPAAGNAGAAPAAAAIAPEAAPVPQGTAAFAPAAEPPATAPMPARAPAPQASRPAAATSAASLIGGASLSSLLSQARRGAAPETAPEAAEQPQPAVTIDPASGQKLESGRTAILDYIRQERPRLYAFFEQLRIEGHTLRLAVPTEALREEILRSKLEMLTRIAAIAGVEGALELEVTINEQIRAVRPIKLEDRLRHMNEKNPLLAELRRELDLEVE
>NZ_AP019739.1|WP_019130318.1|320366_321272_-|hypothetical-protein
MRLSQKITGFLHNGVSTLWYFAVMAVKENFRNYVGRAGRTEGALSDELALLANGPSLADELPRLLAGARAGCDFLAVNYFAEHEAFERLRPAYYVLSDPQFFRASAQRDRVAALYRTLARKVTWPMTLYVQYYNPERFDYRAALPNGHIRIVPFHTQPYRGFRRLEFWLYRHGLGSANFGTVIQHGEYVGLLLGYRTLHLYGVDHTLTEGLTVDRRNRLCRIDRHFYDDGRPAEAHPMYVNATCPPVPYTMASYMAELAELFRGHEVLRDYAASLGARIVNHTRTSMIDAYERAADDRPST

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Crispr_ID: NZ_AP019739_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_4

596875-596985

Orphan

Consensus_repeat	Method
CGTTCGGCTCTGCACTCGACTTAACGAAATGGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_4

>merge|NZ_AP019739|4|596875-596985|CRISPRCasFinder
CGTTCGGCTCTGCACTCGACTTAACGAAATGGTTGGATTTCTTTCTTCCATTTCTCGCCTCGGCATAGCCCGAACTTCGTTCGGCTCTGCACTCGGCTTAACGAAATGGTT

>NZ_AP019739|4|3|596875-596985|CRISPRCasFinder
CGTTCGGCTCTGCACTCGACTTAACGAAATGGTT	GGATTTCTTTCTTCCATTTCTCGCCTCGGCATAGCCCGAACTT
CGTTCGGCTCTGCACTCGGCTTAACGAAATGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141418336.1\|605619_606618_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224619
NZ_AP019739.1\|WP_141418337.1\|607285_608332_+\|glycosyltransferase-family-9-protein	unknown	unknown	gnl\|CDD\|340821
NZ_AP019739.1\|WP_026074856.1\|588283_588688_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418331.1\|588826_589828_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_AP019739.1\|WP_141418335.1\|603838_604744_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019130214.1\|597416_598481_+\|DUF4435-domain-containing-protein	unknown	unknown	gnl\|CDD\|373095
NZ_AP019739.1\|WP_141418329.1\|585346_586543_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl\|CDD\|235513
NZ_AP019739.1\|WP_019130206.1\|606696_607302_+\|DUF4254-domain-containing-protein	unknown	unknown	gnl\|CDD\|379447
NZ_AP019739.1\|WP_019130211.1\|600678_601155_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
NZ_AP019739.1\|WP_019130208.1\|604773_605460_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418332.1\|589962_590439_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_AP019739.1\|WP_141419617.1\|593376_596283_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141413613.1\|596467_596782_-\|translation-initiation-factor	unknown	unknown	gnl\|CDD\|211319
NZ_AP019739.1\|WP_141418333.1\|599163_600507_-\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NZ_AP019739.1\|WP_141418330.1\|586547_588194_+\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_AP019739.1\|WP_019130213.1\|598530_599121_-\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NZ_AP019739.1\|WP_019130223.1\|584994_585318_+\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|376482
NZ_AP019739.1\|WP_081584290.1\|590465_592775_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|227342
NZ_AP019739.1\|WP_141418334.1\|601546_603766_-\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|366374
NZ_AP019739.1\|WP_019130217.1\|592913_593354_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141418336.1\|605619_606618_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|224619	COG1705, FlgJ, Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion].	1.13144e-32
NZ_AP019739.1\|WP_141418337.1\|607285_608332_+\|glycosyltransferase-family-9-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	1.78133e-44
NZ_AP019739.1\|WP_141418331.1\|588826_589828_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_AP019739.1\|WP_141418330.1\|586547_588194_+\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	6.9809e-162
NZ_AP019739.1\|WP_019130214.1\|597416_598481_+\|DUF4435-domain-containing-protein	gnl\|CDD\|373095	pfam14491, DUF4435, Protein of unknown function (DUF4435). This presumed domain is functionally uncharacterized. This domain is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 285 and 362 amino acids in length. This domain is sometimes associated with AAA domains.	1.11332e-34
NZ_AP019739.1\|WP_141418329.1\|585346_586543_+\|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl\|CDD\|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0
NZ_AP019739.1\|WP_019130206.1\|606696_607302_+\|DUF4254-domain-containing-protein	gnl\|CDD\|379447	pfam14063, DUF4254, Protein of unknown function (DUF4254). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 195 and 207 amino acids in length.	6.90741e-87
NZ_AP019739.1\|WP_141418332.1\|589962_590439_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	2.75502e-46
NZ_AP019739.1\|WP_019130213.1\|598530_599121_-\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	9.81345e-123
NZ_AP019739.1\|WP_081584290.1\|590465_592775_-\|penicillin-binding-protein	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	6.33749e-138
NZ_AP019739.1\|WP_141418333.1\|599163_600507_-\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	4.29426e-122
NZ_AP019739.1\|WP_019130223.1\|584994_585318_+\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|376482	pfam01192, RNA_pol_Rpb6, RNA polymerase Rpb6. Rpb6 is an essential subunit in the eukaryotic polymerases Pol I, II and III. This family also contains the bacterial equivalent to Rpb6, the omega subunit. Rpb6 and omega are structurally conserved and both function in polymerase assembly.	0.000256782
NZ_AP019739.1\|WP_019130211.1\|600678_601155_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	2.0983e-67
NZ_AP019739.1\|WP_141418334.1\|601546_603766_-\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|366374	pfam00930, DPPIV_N, Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.	3.81283e-82
NZ_AP019739.1\|WP_141413613.1\|596467_596782_-\|translation-initiation-factor	gnl\|CDD\|211319	cd11567, YciH_like, Homologs of eIF1/SUI1 including Escherichia coli YciH. Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. The function of non-eukaryotic family members is unclear. Escherichia coli YciH is a non-essential protein and was reported to be able to perform some of the functions of IF3 in prokaryotic initiation.	1.15314e-29

>NZ_AP019739.1|WP_141413613.1|596467_596782_-|translation-initiation-factor
MVYSTDPDFRYTTDEVEEPETLPPDKQTLRVWLDRKQRAGRVVTLVRGFRGTAADLEALGRMLKQRCGVGGSVKEGEIIVQGDHRDRIVEILLRAGYGCKKAGG
>NZ_AP019739.1|WP_141419617.1|593376_596283_-|hypothetical-protein
MRHTLLVAALLLAATVARAQYYSWGADAASLRWRTIRTPDVQVIFPDTAGAIARRTLHFIEAARPSIGYGFRHGPLKIPFVMHPENFRSNGLVMWLPKRVEFLTSPAIDSYSMPWYKQLVAHEYRHAVQYNNLNRGVIKGLSYVLGQQGSTVGLLLLPIWLIEGDAVQMETQMSSFGRALQPSFTMEYRALGDAVRSRRNIDRWFCGSYRTNVPDHYHLGYQIAAYADTRYRENIWDKVAWYGARNPYMIFTTSIALKKFYRTDVGTLFAETFDGLNYYWNALPARRNSSRYLSAEPVESYTTYAFPLAIDAQRVLALKTDYDRPTRFVTIDTESGRERAVAYTGSVSTRPAYADGRVWWTEYRRSTLFEQRVNSQLCYMDLDRGKPKAVRGRRHALYPTPTDRGLAWVEYSPDGRFAVTGEAGVQHWEAPAQTELHGLAWDDRTARLYFLATDDSGMWLGRIEPDGTATHLTEGAYITLSDLTARDGRLYFGSIASGYDEVHCYDLATGRQYRLSTSTYGSFSPSADGEGNVLMTTYDAEGYHAARQPIDTLRPVRPSRLPRNVVNPPRRKWPVANLDTVRFTAADSVSSAARHRARRYSRPLHLFKVHSWMPVAVNPFKIIDEHDIDVQLGVTLISQNLLSSAESYLAYAWNHAEGSVVKGSLRYNGLGVELEVAGTYGGNQVIYAAGQAQPQPIPDKYYSLSAGATLPLVFAAGYRTRMLSLTAAWNFSNGLVANVGKLTYDEATHSFTNLQHIGYREGLHKLTFGIGYSNSVQLAHRDFITPRGYVLSASYALNPTNDHFSDLISVYGKLYTPGFAPHNSLTAAATYQTSIGGFKNPAGESFLSYKSARLIPRGFDSNDINSRNYFAASLDYQLPVWYPEGGIPSVLYFKRIRLNLGADYGQFDAFDYRKGRTETRRIHSFGGDLYVDFNVFRQPASATSTLRLSFYAPSKGGLWWSASLGLPF
>NZ_AP019739.1|WP_019130217.1|592913_593354_-|hypothetical-protein
MKRILPLLFALCAGSALPPLSARNLPAGETPQTTVPAANEAERFIRHFYTNCVFGNAACGPILEKCCTQRLLRKLRADYGYDGEGYAVWLFRTGAQDGPDDVSEIREVASLGDGRYRVDFVDMGTEGRRIVKIVDENGAMKIDAVE
>NZ_AP019739.1|WP_081584290.1|590465_592775_-|penicillin-binding-protein
MLTLTALGAFGRMPSFEELENPRSNIATEIYSEDGKVLGTFFVQNRSYVQYEELFASDSVTRTSINGREVPPIVAALIATEDARFDSHSGIDIPSLIRVGVKTILLQNRSAGGGSTITQQLAKNLFPRDTVRRQSALLRKGKLVLAKFKEWITALKLEYNYTKEEIAAMYLNIVEYGSNAYGIKSAAHTFFNKTPDQLNLQEAAVLVGVVNAPTRYSPVRNYDNAMARRNLVLARMAEAGAITHAERDSLSALPITLNYRPVSHNDGQATYFREMLRQVMNARPPKRRNFYTEWDYEQAVKEYENNPIYGWCHKNTKADGTPYNIYKDGLKIYTTINSTMQQYAEEAMLKQLRTVIQPKMDAQYRSTKVLFQNTSAEEREKIVRQAMRYSDRYRALKEEGRSEAEIDRIFRTPCPTRVFTYRGERDTILSPRDSILHHKRIMRAGFVAIEPQTGRVKAYVGGPNFRYFKYDMAKQGKRQIGSTIKPFVYTFAIDHLGLTPCTPVPNLPVTIDTSNGTPWSPKEASKVVYDGEMHPLKWGLARSRNNYSAWIMKQAKQPEAVADFIHNMGIRSFIDPVYALCLGTSESSVFEMVSAYSTFANGGVHTDPIFVTRIEDRQGNLIATFIPESQDAVSERTAYTMLTMLQSVVTNGTAGRLKWQFDLGDAQLGGKTGTSQRNRDAWFMCVAPKLVAGAWVGGEDQSVHPTYGGEGSIMALPIVGEFFSTVYKNPALGISKQDRFRRPDRVTEYDCEEEMQQSQYTEEEEGFFD
>NZ_AP019739.1|WP_141418332.1|589962_590439_-|GNAT-family-N-acetyltransferase
MTIRAPKPEDAAAVAALYNHYVLHSTASFETEPLDAEQMRSRLESATARLVCEREGAIVGFGYTHDWKERAAYRHTQEVTVYVASDSTGLGIGRRLVERLVAECRTTECHALVACITADNEPSRRLFESIGFRRVSHFEQVGRKFGRWLDVVDYELLL
>NZ_AP019739.1|WP_141418331.1|588826_589828_-|aspartate-semialdehyde-dehydrogenase
MKIAIVGASGAVGQEFLRILEERPLPVDELLLFGSERSAGQTYMFRGKPVTVKLLRHNDDFRGVDIALTSAGAGTSREFAGTITRHGTLMIDNSSAFRMEPDVPLVVPEVNGRDALDAPRRIIANPNCTTIQMVVALQAIERVSHIRRVHVATYQSASGAGAQAMAELERQYADLAEGREPKVEKFAYQLAYNVIPHIDVFTDNDYTKEEMKMYHETRKIMHSDIEVSATCVRVPVMRAHSESIWLETERPVSPDEARAAFEAAEGIVVMDDPAQKVYPMPLFIAGKDPVYVGRIRRDVTNPNGLAFWCVSDQIRKGAALNAVQIAEWLLKNR
>NZ_AP019739.1|WP_026074856.1|588283_588688_-|hypothetical-protein
MKKHLGLLTVLAVIALTVFFYFRFFFVFGEGVKSGELNYVVYKGVLFKTYEGKLIQTGIRSKEAGSIQSYEFEFSVEDPALARELMLQGGRTLELHYKEYFGALPWRGFTKFIVDSIVTIGPPVRRGVELPPVQ
>NZ_AP019739.1|WP_141418330.1|586547_588194_+|DNA-repair-protein-RecN
MLRRLSVSNYILIDSLEIEFDPRLNIITGETGAGKSILLGALGLLLGNKNEGAALRDTQRNCVIEGVFDIAAYGLRPFFEANDLDYADEAVVRRILTPAGKSRAYINDLPVQLTQLREFGSRLIDIHSQHQNLILASEEFRTEALDTVAGNGELRAAYRAKYERLQELQRTCARLRAEADAARRDEEWLRYQSEELTAARLRAGEVAELEAEQAVLANADRIGEAITAVRNAFDGDEIGVLAQVKNAEVEIGRLGGSYPHAADLSRRLRSVLEELKDIAATLAEDGERIETNPERLQKVDDRLNTLYTLCQKHRAADEGELIALRDRYAAQLDAITHSDEELAALQAEIGAARNEAELLASELHRTREQAAPAFAGQIVATLVRLGMPDARFEAAVVDCGALTEGGRDRVEFRFSANRTTPPAAVERIASGGELSRVMLALKALLARRMQLPTILFDEIDTGVSGRIADAMGEIICALAETMQVVDITHLPQVASKGSTHFVVYKRDGETHIARLTPDERTTEIAKMLSGSEVTEAAMTQARILLGGK
>NZ_AP019739.1|WP_141418329.1|585346_586543_+|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MLKDKHILLGITGSIAAYKAAVLCRLLKTAGADVRVVMTPLAKQFITPLTMATLSKNPILVDFFDPENGAWNSHVALGEWADCYLIAPATANTLAKMAHGVADNLLLTTYLSSRAPVVVAPAMDMDMYAHAATQANLDTLRRTGVQVVEPGDGELASGLSGKGRMAEPAEIVAFAERLLAEKKKTLCGKRFVVTAGATIEAIDPVRYISNHSSGKMGYAIAGELAARGAEVTLVTGRTALPTPAGVTRCDVLSAEEMYRAATAAFNRADGAVMCAAVADYTPETCADRKLKKGDGELTIRLRRTKDIAAELGSRKGGRVLVGFALETDDEEAHAREKLRRKHFDFVVLNSLRDAGAGFRGDTNKVTFVSESGNEPLPLLAKREVAARIADKIETLINE
>NZ_AP019739.1|WP_019130223.1|584994_585318_+|DNA-directed-RNA-polymerase-subunit-omega
MEIKKNIPNNTITRKLVDLDRETGNIYETVNIIARRANQISAELKTELNRKLAEFSTTTDTLEETFENREQIEISRYYERLPKPAIIATEEFLDGELFFKEGAKTEN
>NZ_AP019739.1|WP_019130214.1|597416_598481_+|DUF4435-domain-containing-protein
MSRKFVDKLGRLNPFGSRCKELPKALPVHSSQRLVRVFVEGYEDVAFWRGVFDRFTNPYLRFEISVPSREDLPKGKKVLLGMIPQASDELLLCVDSDFDYLFHNSTEQSRELLSCDRMFHTYAYATENYLCYAPSLHNVCVRATKNDTRIFDFERFMADYSRIIYPLFLWYAYSAQQESEHIFTLADFRASVRLNFLEIEHNGLRTLAWLRRNVARRDQALRERHAEMIEPKRAFAEKLFRRGVTPENTYLFMHGHTLMDNVVIVLLNTVCEKLRELSIAKITASSKKGVALKNEMSNYTNSLRSIRDVLLDNENYTDCFLFRRLQCDIERYLLSVLGEKRMREVFGDAMIVRP
>NZ_AP019739.1|WP_019130213.1|598530_599121_-|DNA-3-methyladenine-glycosylase-I
MNDLINARCGWAGTDELYVKYHDEEWGKPVDDDRILFEFLVLESAQAGLSWITILRKREGYRKAFHRFDPERVAQMTPEEVDRLMRFDGIVRNRLKITAAINNAKLFRAIQKEFGSFYEYVLSFFPGRQPIVNDFKSLSQIPATSPESDAMSRDMKKRGFKFFGSTICYAFLQATGFVNDHLTGCRCKGGRQQTAP
>NZ_AP019739.1|WP_141418333.1|599163_600507_-|cardiolipin-synthase
MYLFLTAYLLLAIPSAAAVLRQKQTPVVAIAWLLAIVLLPIGGSLFYLLAGYRKPVRDVPPTDSRPAAGIERMLWYGCSTRVRYRNRVEQLHDGGEAFAALISALQGARRYIHLSYYIFADDRIGHAIADILVRKARAGVEVRLLYDAIGSWKLSERFVRRLRGAGIEVRAYAPLRFPWFSPRANRRNHSKIAVIDGRTGFVGGINIAERYLDGDALGRWRDEHLRIEGEAVDDLQRLFAADWALEGGEPLSEGLYAAAPADDLPCSPLQIAWTREDRSRTTLTDLFAQLIEEARHTLRISSPYFLPPPALYEALLRAVRRGCRVLVMLPARSDVWLARRATDAYLGELLGAGVEIFRFRGGFLHAKRLIADERVASVGTANFDYRSLEYNTEATALLLDSATVRQAIRRFDEDLASCTPIDPEAWRRRSVHYRLGDRIARLFAPLL
>NZ_AP019739.1|WP_019130211.1|600678_601155_+|transcription-elongation-factor-GreA
MAKEIIYLTAEGYKKLKDDLDHMRSVERPAISAAIAEARDKGDLSENAEYDAAREAQGLLEMRIAKLEETIANARVIDESKIDKSKVQILSRVTLLNHTNGKQMCYTIVSENEANLREGKLAIGTPIAKALLGKKKGDRVDVEVPAGTIHFEILDISI
>NZ_AP019739.1|WP_141418334.1|601546_603766_-|prolyl-oligopeptidase-family-serine-peptidase
MRISKLPNLFLALLACSTAAAQAFDYDDIADGRFRPAQLAGIRPTADGEHYTTIRDGNIFRHRYAVDDAGTALLPAAAEEGAVALDSLDRATGTWCDAGSRRLDIADYAIAPDGGVLVADGAEPIYRHSFTTRYLYYDGRRLREILLGIPSPRDAVFTPDGRNIVFSSRNNLYVYNIERQGTRQITRDGRWNETINGTTDWVYEEEFGFTRAFAVSPDSRRIAYLRFDESRVPLFEMMRYDGALYNRAYDFKYPKAGDANSVVTLHVFDLETGRTTKVDTGADTTQYIPRIGWTPRGELWYETRDRRQQQIVFRRLAADALTAPQAEQQTVYRERSPRYVAHETDRSFRWIDGGRRFLIMQETATGWMHLYLGEPGEPLRALTEGRWEVTAIVGADDRAVYYTSTERSPLERNLYAVDYKGRHKRLLTPDKGFHTIAPSAGMRYYISTFSSADDPGRVEICDARGRTVRTVADNAALRRLADSIRLPRKEFFTFTTERGDTLGGYIVRPAGFDPARRYPCLLTQYSGPGSQTVQNRWKLDWEDVLAQRGYVVVATDGRGTGYRGEAFKKSTYGQLGRLEVEDQLSTARYMAAQPWIDAERIGIYGWSYGGFMALSCACKGDGLFKAAVAVAPVTSWRYYDTIYSELYNGLPQENPAGYNENAPLMLAPLLRDDRTRLLLIHGTADDNVHFQNSAEMIRALTDAGKEFDLMIYPDQNHSMQPDYTRQIRQRMISFVERNL
>NZ_AP019739.1|WP_141418335.1|603838_604744_-|hypothetical-protein
MKPICLLFVLPLLGTGCRTEQSAYLEKALSQLERIERVAYRRSSESYLPGDTIPRRYLRYYVEQRNRADTTLRHSYLSYYNADDTTRIDGGYDGTIAVDLDHDRREVVIDDFSIPRAPYRLTDMTFFCRAEAILRYVLTTSDPIRTEFTPCGDGYRLRLDIDRDCVVEFWGRPYYNRPPRELFLEAEHSAYEIVFDSERMPRKLRREQTHQITVDSVFDVRIDYEPQAPLRLEAYYPDGYMLRKRKLRNQAKKPYDIVGRQAPDWTLVDAERRVRHAFCGYTPAESDRTITEAIDSLLREQ
>NZ_AP019739.1|WP_019130208.1|604773_605460_-|hypothetical-protein
MDPSPLRAKILETIVRKSSLKQQVFDNTFATFNELKDILFEMSSEWDDELDGRIDRRVRIEYRDRGKFETQFQVASDLLIFRMHTDVFEFDANHLVWQSPYVQADRDNSYCGIIDIYNFLSDSFKFNRNADEGYLIGRIFINRERCYFVEGKRQTSMRPIAFGRAAITREALVGILETAIAYSLDFDLLTPPYEDAKRVTVDQFNTKMDNSKFVTGKRLDYDFDVEDI
>NZ_AP019739.1|WP_141418336.1|605619_606618_-|LysM-peptidoglycan-binding-domain-containing-protein
MKKSILVAILFLSGFGALHAQTRQTREEYIDRYKHIAVAHMERYGIPASITLAQGILESDCGNSALSRSSNNHFGIKCKSDWTGRRVFHDDDARGECFRAYGSVEASYEDHARFLDSQPRYDSLFVYPADDYRSWARGLKAAGYATAPDYAQRLCRIIEETQLYLLDRPQGEALYAARNRSRAEQAVEGFEAGSSVNPLTPANEERIDPDDFRVTINAYKGYNIYVTNGVNYIVAKEGDTFESLAEIFCISARNLRKFNDLKGKAQPVRGEQIYIDRKQKRWEGNARHHIVTEGETVASVAQSYALREKSLRKLNRLKAGAALRTGQTLRIR
>NZ_AP019739.1|WP_019130206.1|606696_607302_+|DUF4254-domain-containing-protein
MFTENANRIFNRAIDDYHRFDDVDHPVENPFDEGSLDHLLYMKNWVDTVQWHLEDIIRDPQIDPVEALAIKRRIDKSNQVRTDMVEYIDSYLLDKYKAVVPQSDARLNTETPAWAIDRLSILALKIYHMRQETQRSDVDEAHRDACRKKLDVLLSQQVDLSRAIEELIEDIEAGRKYMKTYKQMKMYNDPALNPVLYGAKK
>NZ_AP019739.1|WP_141418337.1|607285_608332_+|glycosyltransferase-family-9-protein
MALRNRKLPRHILVIRNSAMGDVAMVPHALRALREAYPDVRVTVLTRPLFKPFFAGLDVDFLEADYAGRHKGVLGLLRLAGEARRRGIDAVADMHGVLRSRIIGLLLRLHGMPAARIDKGRIEKWFRLGCTNPAASPLKHTVVRYCDVLRRLGFVFDDPQPAAKPVRPNPFGEKKGVWIGFAPFSAQAGKTYPEDLAAGLVAGLSARYDRVFIHSGGGGEAAFAERMEREHPNVTALWGRVRFAGELDLIANLDCVVSMDSLAMHMASLVATPVVSVWGATHPALGFLGYGCPPEGVVQLDLPCRPCSVYGQRRCKFGDYRCMRIPPQAVLDRVEECLSIRRAEEAGC

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Crispr_ID: NZ_AP019739_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_5

677861-677969

Orphan

Consensus_repeat	Method
AAAAGCAAATGAAATTTGCATTGCACTCGGCTTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_5

>merge|NZ_AP019739|5|677861-677969|CRISPRCasFinder
AAAAGCAAATGAAATTTGCATTGCACTCGGCTTAGTCGTATCTTTGGCTGACGTCTTAGATACTCCGCCTCGGCAAAAAGCAAATGAAATTTGCATTGCGCTCGGCTTA

>NZ_AP019739|5|4|677861-677969|CRISPRCasFinder
AAAAGCAAATGAAATTTGCATTGCACTCGGCTTA	GTCGTATCTTTGGCTGACGTCTTAGATACTCCGCCTCGGCA
AAAAGCAAATGAAATTTGCATTGCGCTCGGCTTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019130153.1\|679494_681252_+\|V-type-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|235248
NZ_AP019739.1\|WP_141418367.1\|673100_674108_-\|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl\|CDD\|234593
NZ_AP019739.1\|WP_141412861.1\|670504_671575_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|224383
NZ_AP019739.1\|WP_162851454.1\|687229_687988_+\|UPF0280-family-protein	unknown	unknown	gnl\|CDD\|235284
NZ_AP019739.1\|WP_141418363.1\|668205_668673_-\|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl\|CDD\|234674
NZ_AP019739.1\|WP_141412868.1\|686812_687226_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|197998
NZ_AP019739.1\|WP_141418371.1\|678654_679488_+\|DUF2764-family-protein	unknown	unknown	gnl\|CDD\|314007
NZ_AP019739.1\|WP_034779569.1\|667138_668176_-\|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	unknown	unknown	gnl\|CDD\|234858
NZ_AP019739.1\|WP_162851477.1\|683205_685029_+\|V-type-ATP-synthase-subunit-I	unknown	unknown	gnl\|CDD\|235600
NZ_AP019739.1\|WP_019130151.1\|682588_683197_+\|V-type-ATP-synthase-subunit-D	unknown	unknown	gnl\|CDD\|179382
NZ_AP019739.1\|WP_141418366.1\|671577_672918_-\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|274129
NZ_AP019739.1\|WP_141418362.1\|666080_667136_-\|DUF4369-domain-containing-protein	unknown	unknown	gnl\|CDD\|239264
NZ_AP019739.1\|WP_141418365.1\|669727_670492_-\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|376449
NZ_AP019739.1\|WP_019130149.1\|685074_685506_+\|ATPase	unknown	unknown	gnl\|CDD\|235830
NZ_AP019739.1\|WP_141418364.1\|668984_669605_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019130152.1\|681262_682582_+\|V-type-ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|179373
NZ_AP019739.1\|WP_141418370.1\|678032_678647_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179302
NZ_AP019739.1\|WP_141418369.1\|675895_677332_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224423
NZ_AP019739.1\|WP_019130148.1\|685646_686792_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376627
NZ_AP019739.1\|WP_141418368.1\|674366_675800_+\|DUF4301-family-protein	unknown	unknown	gnl\|CDD\|372920

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_019130153.1\|679494_681252_+\|V-type-ATP-synthase-subunit-A	gnl\|CDD\|235248	PRK04192, PRK04192, V-type ATP synthase subunit A; Provisional.	0
NZ_AP019739.1\|WP_141418367.1\|673100_674108_-\|UDP-N-acetylmuramate-dehydrogenase	gnl\|CDD\|234593	PRK00046, murB, UDP-N-acetylmuramate dehydrogenase.	2.34458e-165
NZ_AP019739.1\|WP_141412861.1\|670504_671575_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|224383	COG1466, HolA, DNA polymerase III, delta subunit [DNA replication, recombination, and repair].	9.24559e-32
NZ_AP019739.1\|WP_162851454.1\|687229_687988_+\|UPF0280-family-protein	gnl\|CDD\|235284	PRK04334, PRK04334, hypothetical protein; Provisional.	1.16807e-61
NZ_AP019739.1\|WP_141418363.1\|668205_668673_-\|pantetheine-phosphate-adenylyltransferase	gnl\|CDD\|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	2.2427e-62
NZ_AP019739.1\|WP_141412868.1\|686812_687226_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|197998	smart00930, NIL, This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins. This domain is likely to act as a substrate binding domain. The domain has been named after a conserved sequence in some members of the family.	6.51938e-15
NZ_AP019739.1\|WP_141418371.1\|678654_679488_+\|DUF2764-family-protein	gnl\|CDD\|314007	pfam10962, DUF2764, Protein of unknown function (DUF2764). This bacterial family of proteins has no known function.	2.94143e-42
NZ_AP019739.1\|WP_034779569.1\|667138_668176_-\|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	gnl\|CDD\|234858	PRK00892, lpxD, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional.	7.1261e-155
NZ_AP019739.1\|WP_162851477.1\|683205_685029_+\|V-type-ATP-synthase-subunit-I	gnl\|CDD\|235600	PRK05771, PRK05771, V-type ATP synthase subunit I; Validated.	3.25592e-91
NZ_AP019739.1\|WP_019130151.1\|682588_683197_+\|V-type-ATP-synthase-subunit-D	gnl\|CDD\|179382	PRK02195, PRK02195, V-type ATP synthase subunit D; Provisional.	1.31836e-68
NZ_AP019739.1\|WP_141418366.1\|671577_672918_-\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	1.98789e-65
NZ_AP019739.1\|WP_141418362.1\|666080_667136_-\|DUF4369-domain-containing-protein	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.07336e-26
NZ_AP019739.1\|WP_141418365.1\|669727_670492_-\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|376449	pfam01063, Aminotran_4, Amino-transferase class IV. The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.	6.22079e-14
NZ_AP019739.1\|WP_019130149.1\|685074_685506_+\|ATPase	gnl\|CDD\|235830	PRK06558, PRK06558, V-type ATP synthase subunit K; Validated.	2.58165e-23
NZ_AP019739.1\|WP_019130152.1\|681262_682582_+\|V-type-ATP-synthase-subunit-B	gnl\|CDD\|179373	PRK02118, PRK02118, V-type ATP synthase subunit B; Provisional.	0
NZ_AP019739.1\|WP_141418370.1\|678032_678647_+\|hypothetical-protein	gnl\|CDD\|179302	PRK01558, PRK01558, V-type ATP synthase subunit E; Provisional.	1.41384e-20
NZ_AP019739.1\|WP_141418369.1\|675895_677332_-\|hypothetical-protein	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	0.00458269
NZ_AP019739.1\|WP_019130148.1\|685646_686792_+\|hypothetical-protein	gnl\|CDD\|376627	pfam01837, HcyBio, Homocysteine biosynthesis enzyme, sulfur-incorporation. This presumed domain is about is about 360 residues long. The function of this domain is unknown. It is found in some proteins that have two C-terminal CBS pfam00571 domains. There are also proteins that contain two inserted Fe4S domains near the C-terminal end of the domain. The Methanothermobacter thermautotrophicus gene MTH_855 product has been misannotated as an inosine monophosphate dehydrogenase based on the similarity to the CBS domains. Based on genetic analyses in the methanogen Methanosarcina acetivorans, this family is a key component of the metabolic network for sulfide assimilation and trafficking in methanogens. It is essential to a novel, O-acetylhomoserine sulfhydrylase-independent pathway for homocysteine biosynthesis, and may catalyze sulfur incorporation into the side chain of an as yet unidentified amino acid precursor. The DUF39-CBS and DUF39-ferredoxin architectures repeatedly occur together in the genomes of methanogenic Archaea, suggesting they may be of diverged function. This is consistent with a phylogenetic reconstruction of the DUF39 family, which clearly distinguishes the CBS-associated and ferredoxin-associated DUF39s.	0
NZ_AP019739.1\|WP_141418368.1\|674366_675800_+\|DUF4301-family-protein	gnl\|CDD\|372920	pfam14134, DUF4301, Domain of unknown function (DUF4301). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 505 and 516 amino acids in length.	0

>NZ_AP019739.1|WP_141418369.1|675895_677332_-|hypothetical-protein
MKKLSFTCLGILLSVCTSCSNSDEEEKDWTGQPSVTISDPVGEKDISITITPENAVAAAYTCIAEGGGSEPTAEEVLEKGIQIDATQPSTIVIDWLDYDTDYVVIAAVRSKEGTVASDTAEITTAKDPAIDLGQGANTYIVSKAGTYSFTPEKVDGTPIDGIASANWIWATKADENDKEQKLLDNVAYAGGKIRFTTTGERGNAVIAAFDATGKSIWVWLIWCTEQPEEMEYENGGVFLDRFLGATAAELTDGEATWGNILYQWGRNVPIYAGYDDEWGEEEVFNEARKWTIMNPELFFFWDVSKSLTSVAGSLAAPTTFFADQKTCNWTVEDQSLWGETKTNYDPCPAGYRLPSEKSWGNFFSDLKILEDESGATYTYKGKTAWYPAMNNGRMFDTGENIKGFPAFTVWNCSYMIADPMGILDMNPPYSMEELIEMGLIISAPQRAYMQYNNMQDVVNAHFAVANPSFAFAVRCVKE
>NZ_AP019739.1|WP_141418368.1|674366_675800_+|DUF4301-family-protein
MFTEQDTACIRAHGLTPEAVERQLENFRRGFPFLKVVRAAAPGDGILVPAPQEVAAAMRRYDEAAARLGIVKFVPASGAATRMFKELFAFVEEGRRSEGIDRLLQNIERFAFWPELRATLPAGADDRTVVEHIIGKGLGYGGRPKGLVTFHAYAEGARKAAEEHLVEGAQYAAAGGRVRIHFTVSPEHRADFEALMAEKVPLYERRFGVHYDIAFSEQKPSTDTVAVNPDNTLFRTDAGALLFRPAGHGALIENLNEIDADLVFVKNIDNVTTDARRGDTVTYKKVLAGLLLELQERSFEYIRALDTGGAELADIARFIRERLCVKLPDDYNSAVLRAVLDRPIRLCGMVRNEGEPGGGPFWAVNDDGTESLQIAESSQIAPADRPLMQRATHFNPVDLVCGVRNVRGEKFDLRRYTDPQTGFISSKSYAGRELRAQELPGLWNGAMARWNTVFVDVPVTTFSPVKVVLDLLRPQHQ
>NZ_AP019739.1|WP_141418367.1|673100_674108_-|UDP-N-acetylmuramate-dehydrogenase
MIRDFYDIDLSGRNSFHVRQRAARLVEFETTDDLTAFFRKGAPAKWTVLAGGNNILFTQDFDGVLLTPRAASIDVVAETPDAVAVRAEAGVEWDDLVAWAVERDLWGIENLSLIPGKVGAAPVQNIGAYGAEAKDAIESVEMFCTDTCNTLILSREHCAFGYRESVFKHALRGRVVITAVTFRLSRRPRPDLGYGDLLRETEARGGATLRNIREAVCAIRRSKLPDTAVLGNAGSFFKNPVVEAAVAERLRTDYPALPLYPAAEGRMKLAAGWLIEQAGMKGHREGCVGVHDRQALVLVNYGDATGGEVLALAHKVQEAVRAKFGVEIAAEVNVL
>NZ_AP019739.1|WP_141418366.1|671577_672918_-|tRNA-lysidine(34)-synthetase-TilS
MLTDRFQSYVERHGLFSRDDRILLTVSGGVDSMVLLSLMASLGYRFGVAHCNFQLRGAESDEDEVIVAREAARYGVPCYNRRFDTAAEMERTGESMEMTARRLRYAWFEELRREHGYAAIAVAHHADDSIETFFINLLRGTGLRGLTGISTRMGRVVRPLMFASRREILEYAVAQKIPFREDSSNRSTKYLRNKIRLGLIPRIREINPKFTDLMRRNIERLTDTQLFIDAAVAHMREDVVTQADGIATIHVERIEAAYPRNFAVYELLSSQYGFKGDVCDALCRALSEAATGRRFYAREYVATVDRGRILVERIAPGDACEVTVEQGTQRSYCGNMVLYFEACDIDDIRAYDVPEQVALLDADLLRYPLRLRRWREGDTFIPFGMEGRKKVSDYLIDRKVSLPEKQRQFVLLSGDEIVWLVGRRIDDRYRLTDRTENVLRITKEII
>NZ_AP019739.1|WP_141412861.1|670504_671575_-|DNA-polymerase-III-subunit-delta
MAKSAVRFRDSVAQFERLSADIAARRFAPVYLLMGDESYFIDALCDRLASTILGEAERSFNQIVLYGRDTEPGQVINFCRQMPMMGSYEVVILKEAQQMRQIEKLSLYTQKPQASTILVVCHKEKSVDKRSAFYKQAAACGAVFESVRPRDYEIGPWLSGFIASKGCRIDEKALSMLTDHLGCDVSKIANELEKLLVSLPEGTQRITDRDIERNIGISREYNNFELCKAVLGRDMARALRIADHFGRNPKENPLLVTVLALFGQFRQLFVLNYLYWLARRRGTGAPSDAELMRALKVGNVFAINELRQAMPRWPNNKVFGVLGLLREYDGKSKGLDAGGASDGELLRELLLKMLTI
>NZ_AP019739.1|WP_141418365.1|669727_670492_-|branched-chain-amino-acid-aminotransferase
MTDFCSIDGRLTPLGEGLPGGVYLYQRLRTVDYRPLHTAAHLSRLRDGAGSLFGRPAELPAGRIADEIGALLRANGYPAGGATVTLRLYADGTYALTADGVSLYRTYALRSLRPAAAVVPCDGYRPEWPTSARRETARWAQQEAERSGARCALLCDRDGIVRRAGDAPLFAVRDDVIYAAPLDDVEWTLVAEAARRAGIRWVERPVGAAQLRLFDELFSFDCEGVSSIASCEGTPYLSLTAERIAAALAALPER
>NZ_AP019739.1|WP_141418364.1|668984_669605_-|hypothetical-protein
MKKFLLLYALAVTLSLAGVLRRYRTETHRLEQNQRALLSQVERYRTRAGEAAASAEVLQLRCREFERLRAGDAERIRQLGIRLRRVEAAATLATATEIDVQVPLHDTIARRDFAAVCDSGRLAAAVRFDTVRSFRWRDPWVTVEGRIRGDSADCRVESVDTLRQVVHRVPRRFLFIRFGTKAVRQEIVSSNPHTRIVYAEYVRFAK
>NZ_AP019739.1|WP_141418363.1|668205_668673_-|pantetheine-phosphate-adenylyltransferase
MKTAIFPGSFDPFTRGHEAIVEKALHLFDKVIIGIGSNVAKQGLLSVENRKRLIDDYYAGDARVEAMIYSGMTGDFAQQVGAAAVIRGVRNTTDFEYERTMAATNRRLYPAVVTVMLFTPPDVADISSSTVREVLAFGRSVAEFLPRGIELENYL
>NZ_AP019739.1|WP_034779569.1|667138_668176_-|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase
MMEFTAEMIAGFLGGDIVGDKTVKVHTVSSIEEGKAGSMAYLVNPKYEPFLYTTEASIVLVDRSFTPQREVKPTLVKVDDAGAAVLRLLEMYNAARPQKKGVSERASISPEASLGEGCYVGDFAVIEAGARIGDGCRIYPQVYVGDGVEIGEGTTLYPGVKIYEGCRIGSRCILHAGAVIGADGFGFAPNAEGGFDKIPQLGNVIIEDDVEIGANTCIDRAKTDSTIIRRGVKLDNLIQVGHNVQIGEHTVSSAQMGIAGSSKIGRNCFLAGQVGIADHVTIGDRVKIGSQSGVDKNVPDGEVRMGTPALPGIKFHRANAVFRNLPELQQRLSALEKAVNQLIEK
>NZ_AP019739.1|WP_141418362.1|666080_667136_-|DUF4369-domain-containing-protein
MKRTLAFAASLLLLGACSSDGYTIRGKIAGLDNPYVYLLRYTGEVEVIDSAKVTKGDFVFKGKAEQPEVVYLSTDKQQPFVHFFLENGRISVDGALSAPADIAVLGTPSNDIQRAFDEKIAALEEEFAKAGNDVQRDSLRKEYSKLMSDAVEMNRDNIYGVTTFLNNAYAFLSPEEVMEQIALFPAEWQQRRELTELREATERKLRVSAGHPYIDIAAKNADGGEVSLKSVVENRRNKYVLLDFWASWCGPCMAEIPFLKADYEKYGKKGFEIYAVSFDSQRDRWIDAVRQQGMKWIQVSDLSGFQTPAAEAYAVQSIPSNFLIRCSDGQIVATQLRGEALGEKLGELLGD
>NZ_AP019739.1|WP_141418370.1|678032_678647_+|hypothetical-protein
MENKLQQLTQKLYDEGLEKGRAEAERLVSEAKSEAAKIIADAKAEAEAIVKAAEAKAEDTAKNSMTEIALAGKQAVARIKEEISSLIAAESTFSAVKAANLDPEFVKAMLLSVARNWNGASSSKVELQVLLPEAERAKFDAAFAAAAKELLEAGIEVGYSKEVRTGFKVGAKGGSYYISFSDDDFEALLKEYLRGKISELLFKA
>NZ_AP019739.1|WP_141418371.1|678654_679488_+|DUF2764-family-protein
MFDTNYYCLVAGLREYSLDGGAKGFDPHAILDEILRELTPRDLRAVRLLYGYYDCKNLIALRAGSPAHDPLGNFARERLKEETEHPRLLPHAIGLVLAAYARPDGEEAEEVDTSRPFEQALFEAYYGLCAASPSRFLREWSDFDRTLRNVAAATTARAAGRPVDGHVVGNDDVAEQLRRSSASDFGLRGELPYIDAVIAAVNDESNLLEKEHKIDRIRWQQAVDLAAEDYFNVNAVLSYLVRINLVARWTQLDEARGRAMLGRLLRELDGKELINNK
>NZ_AP019739.1|WP_019130153.1|679494_681252_+|V-type-ATP-synthase-subunit-A
MKTTGRVNGIISNIVIVKADGPVAQNEICYVWTGDTKMMAEVIKVIGDDAYVQVYDSTRGLKIGDRVEFEGHMLEATLAPGLLSRNYDGLQNDLEKMDSLFIERGSITDPIDFDKTWEFTPLAKAGDKVSAASWLGEVKEQWIPHKIMVPFTMTGSYTVKSVAAAGSYKVTDTVAVLTDAEGGDHEVTMVQRWPVKQAIRSYVEKPRPDRIMETGVRAIDTFNPLAEGGTGFIPGPFGAGKTVLQHAISKQADADVIIMIACGERANEVVEIFKEFPELIDPHTGHPLMERTIIICNTSNMPVAAREASVYTGMTIGEYYRAMGLKVLVMADSTSRWAQALREMSNRLEELPGQDAFPMDLSAIISNFYSRAGLVRLTNGQTGSVTFLGTVSPAGGNLKEPVTESTKKAARCFYALAQARADSKRYPAIDPLDSYSKYLEYPEIREYLDAHIGKGWVDNVYAGKTLVQRGKEANDQINILGDDGVPVEYHERFWKSELIDFVILQQDAFDDIDANCPLERQKMMFEMVLDICNKTFDFADFEECSKFFKTLINLFRQMNYAEWQSEKFADYRSQIEALVNEQLNK
>NZ_AP019739.1|WP_019130152.1|681262_682582_+|V-type-ATP-synthase-subunit-B
MTTRAFQKVYTKIDNITKATVTLRASGVGNDELATVGGKLAQVVKIMGDNVTLQVFAGTEGLATDSEVVFHGEPPKLKVSDNLAGRFFNAYGEPLEGGEQIEGEAREIGGPTVNPFRRKQPSELIATGIAGIDLNNTIVTGQKIPFFADPDQPYNAVMANVALRAKADKIILGGMGLTNDDFLYFKQVFENAGALDRIVSFVNTTENPPVERLLVPDMALTAAEYFAVDKGQKVLVLLTDMTLYADALAIVSNRMDQIPSKDSMPGSLYSDLAKIYEKAVQLPNGGSITIIAVTTLSGGDITHAVPDNTGYITEGQLFLRNDSDTGKVIVDPFRSLSRLKQLVIGKKTREDHPQVMNACVRLYADAANAKTKLENGFDLSDYDERALKFAHDYSEKLLSIDINIDIDQMLDTAWRLFAEYFTKTEVAIKEELIQKYWKE
>NZ_AP019739.1|WP_019130151.1|682588_683197_+|V-type-ATP-synthase-subunit-D
MAIKFQYNKTSLGDLGKQLKMRQKALPTIKSKESALRSEVKKAKEAAQEFRSQLSRLEAEYDYMVSLWGEFDCDLLRIADIELTEQKIAGVRTPVLREIVYEEKPYDLFSSPVWYAAGIDLLKRLSKLGIEYELFNRKMELLDFARRKTTQKVNLYEKVQIPGYEDAIRKIKRFLEDEENLSKSAQKIVKTKQQQAGEGQMS
>NZ_AP019739.1|WP_162851477.1|683205_685029_+|V-type-ATP-synthase-subunit-I
MSKYDFILYAGQSDDFIERLRELGLVDVTCRGWEPSEGDRQLVTAIEGRTKALAALERFRSSEHFDAAARPFASGDEAYERYGRTAQERAALRTEIGQTEKAAEEARPWGDFSAGTLQRLARRGVVLRFFTAQRDAFEKSRDAWNEQAPVEVIHETSSTVWFVAVSHEGAELSFDAQEVKAPAMTAHDAEAKVASLRSRLSATDAEMSRAAASAALIERDCNRLREELQRVKVTATAEAAADGTLLVMEGWAERETSDRVDALLDEYPNVLYIKSDPTPEDETPVKLKNNRFARIFEMVGDMYARPKYGTIDLTPFFAPFYMLFFGICLNDAGYGLILLAMGMAMLWKFKGGMMRRAAWFATMCAVSTIVFGLFCGSFFGVSLKVYFPSIPFFDFQGRFFSWALAIGLVQILFGQVLRIVMVSATAGFRYALSTLGWFLVILAGSLAAGLPLLDPAWVIPGFTTSSPAFYGVAAIGVVLMLFFNSPGKNPFVNFGTGLWDTYNNITGILSDVLSYIRLFAIGLSGGILATVFNDLATGLSPDIPVVRELMILLILLVGHGINLFMSSISSFVHPMRLTFVEFYKNAGFEMAARQFEPLTKIDQSENK
>NZ_AP019739.1|WP_019130149.1|685074_685506_+|ATPase
MAYVGVALMVGLSGMASCIGTSIAGMASVGAMKKNAGAFGSYMILAAIPGSQGLYGFVNYFIIKDFLTDEISMLQGAAIFGAGLLTGVVCLASSYFQSKVCANGITAIGNGHDVMGKTLILAAFPELYAILTVAAVFLIGGAI
>NZ_AP019739.1|WP_019130148.1|685646_686792_+|hypothetical-protein
MKKSYEEINEKIRQGKAVVLTAEEVSQLARTLSPAEIVRRVDVVTTGTFGAMCSSGAFLNFGHATPPIRMERIELNGVPVSGGLAAVDTFVGATDCDPARPAYGGAHVIEELVAGRSVTLEAWGKGTDDYPRRHIRSHVTLDDINEAILYNPRNCYQNYNAATNSSERMLHTYMGTLLPKLRNVSYSTAGELSPLLNDPTCRTIGMGTRIFLCGARGYVSWQGTQFNTSKPVNEHGIPIGGARTVAAIGNLREMSTDYLRAAYYEKYGVSLFVGVGIPIPLLDEELAHDVSIRNEQITTNILDFGEEERPIGQTNYAELRSGSIEVRGQRVRTAPVASLRKAREIAETLKGWIARGEFLLTEPVQPMPAHSTVKGLKADDE
>NZ_AP019739.1|WP_141412868.1|686812_687226_+|4Fe-4S-dicluster-domain-containing-protein
MTTKVILYFPSDATDKAVTYDLVKRYDLRINILRAEIEAGRSGSLLVELTGEEPMVREGVAYLERNGVTVSPVASKIAYDRDRCIDCGNCALACFPQALTIGAPDWRLHFDPERCIACKLCLKSCPLGLFHIEFTEA
>NZ_AP019739.1|WP_162851454.1|687229_687988_+|UPF0280-family-protein
MEYVERRYRSRMGRDAVVFTVSHRESDLWVAVDRGDAAVMAARTEHFLHELRVRLDRYLDCDPAYLRALVPCLPRPDAPPLLHEMAVAAATAGIGPMSAVAGAFARETGRMLRREFGVGEVVVENGGDIYADVHRPLDVALFAGESPLSERVGLHIPGGAFPLGICTSSGTVGPSLSFGRADAVMIVCRDVLLADSYATAWANRVRTEEDTGSVVERACRVPEILGAMAVKGERLAVGGTFELRLFGEARDF

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Crispr_ID: NZ_AP019739_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_6

746050-746136

Orphan

Consensus_repeat	Method
TGCTTGCAGGTTATGCCGAGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_6

>merge|NZ_AP019739|6|746050-746136|CRISPRCasFinder
TGCTTGCAGGTTATGCCGAGCGAAGAAGAAGAAATTCAACGTTTTCGTAAGTGAGGGCAGAAGCTGCTTGCAGGTTATGCCGAAGCG

>NZ_AP019739|6|5|746050-746136|CRISPRCasFinder
TGCTTGCAGGTTATGCCGAGCGA	AGAAGAAGAAATTCAACGTTTTCGTAAGTGAGGGCAGAAGC
TGCTTGCAGGTTATGCCGAAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019130113.1\|732295_734428_+\|methylmalonyl-CoA-mutase	unknown	unknown	gnl\|CDD\|236508
NZ_AP019739.1\|WP_019130112.1\|734726_734921_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019130109.1\|738158_738350_+\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NZ_AP019739.1\|WP_162502162.1\|747421_747769_-\|DUF3795-domain-containing-protein	unknown	unknown	gnl\|CDD\|378914
NZ_AP019739.1\|WP_141418394.1\|742735_744025_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366031
NZ_AP019739.1\|WP_141418395.1\|744121_745801_-\|alpha-amylase	unknown	unknown	gnl\|CDD\|200486
NZ_AP019739.1\|WP_141412892.1\|730441_732283_+\|methylmalonyl-CoA-mutase-small-subunit	unknown	unknown	gnl\|CDD\|376584
NZ_AP019739.1\|WP_141412901.1\|760012_761875_+\|PKD-domain-containing-protein	unknown	unknown	gnl\|CDD\|214510
NZ_AP019739.1\|WP_141418393.1\|738712_742507_+\|leucine-rich-repeat-protein	unknown	unknown	gnl\|CDD\|374509
NZ_AP019739.1\|WP_019130099.1\|750347_751127_+\|acyl-ACP--UDP-N-acetylglucosamine-O-acyltransferase	unknown	unknown	gnl\|CDD\|235390
NZ_AP019739.1\|WP_141418391.1\|735173_737018_+\|menaquinone-biosynthesis-decarboxylase	unknown	unknown	gnl\|CDD\|163413
NZ_AP019739.1\|WP_141419624.1\|752418_753399_+\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP019739.1\|WP_019130100.1\|748885_750277_+\|bifunctional-UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase/3-hydroxyacyl-ACP-dehydratase	unknown	unknown	gnl\|CDD\|237296
NZ_AP019739.1\|WP_019130094.1\|758588_759986_+\|PKD-domain-containing-protein	unknown	unknown	gnl\|CDD\|176509
NZ_AP019739.1\|WP_026074832.1\|751725_752280_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_AP019739.1\|WP_141418398.1\|757090_758551_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|185760
NZ_AP019739.1\|WP_141418392.1\|737017_738070_+\|helix-hairpin-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378965
NZ_AP019739.1\|WP_141418390.1\|729928_730285_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418396.1\|746202_747084_+\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|223730
NZ_AP019739.1\|WP_034780076.1\|748001_748802_-\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|273570

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_019130113.1\|732295_734428_+\|methylmalonyl-CoA-mutase	gnl\|CDD\|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0
NZ_AP019739.1\|WP_019130109.1\|738158_738350_+\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	9.5412e-12
NZ_AP019739.1\|WP_141418394.1\|742735_744025_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366031	pfam00328, His_Phos_2, Histidine phosphatase superfamily (branch 2). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.	8.80222e-09
NZ_AP019739.1\|WP_141418395.1\|744121_745801_-\|alpha-amylase	gnl\|CDD\|200486	cd11348, AmyAc_2, Alpha amylase catalytic domain found in an uncharacterized protein family. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The catalytic triad (DED) is not present here. The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_AP019739.1\|WP_141412892.1\|730441_732283_+\|methylmalonyl-CoA-mutase-small-subunit	gnl\|CDD\|376584	pfam01642, MM_CoA_mutase, Methylmalonyl-CoA mutase. The enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. The enzyme induces the formation of an adenosyl radical from the cofactor. This radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA.	4.66269e-176
NZ_AP019739.1\|WP_141412901.1\|760012_761875_+\|PKD-domain-containing-protein	gnl\|CDD\|214510	smart00089, PKD, Repeats in polycystic kidney disease 1 (PKD1) and other proteins. Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.	3.70915e-13
NZ_AP019739.1\|WP_141418391.1\|735173_737018_+\|menaquinone-biosynthesis-decarboxylase	gnl\|CDD\|163413	TIGR03701, mena_SCO4490, menaquinone biosynthesis decarboxylase, SCO4490 family. Members of this protein family are putative decarboxylases involved in a late stage of the alternative pathway for menaquinone, via futalosine, as in Streptomyces coelicolor and Helicobacter pylori. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone].	0
NZ_AP019739.1\|WP_019130099.1\|750347_751127_+\|acyl-ACP--UDP-N-acetylglucosamine-O-acyltransferase	gnl\|CDD\|235390	PRK05289, PRK05289, acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase.	2.83597e-126
NZ_AP019739.1\|WP_162502162.1\|747421_747769_-\|DUF3795-domain-containing-protein	gnl\|CDD\|378914	pfam12675, DUF3795, Protein of unknown function (DUF3795). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. This protein is likely to be zinc binding given the conserved cysteines.	1.12427e-15
NZ_AP019739.1\|WP_141419624.1\|752418_753399_+\|DUF4974-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	1.07164e-32
NZ_AP019739.1\|WP_019130100.1\|748885_750277_+\|bifunctional-UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase/3-hydroxyacyl-ACP-dehydratase	gnl\|CDD\|237296	PRK13188, PRK13188, bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed.	0
NZ_AP019739.1\|WP_141418393.1\|738712_742507_+\|leucine-rich-repeat-protein	gnl\|CDD\|374509	pfam16378, DUF4988, Domain of unknown function. This family around 200 residues locates in the N-terminal of some uncharacterized proteins in various Bacteroides and Alistipes species. The function of this family remains unknown. The N-terminus of this model has been clipped by ~30 residues as it was capturing parts of collagen sequences, pfam01391.	5.34827e-33
NZ_AP019739.1\|WP_026074832.1\|751725_752280_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	8.74177e-51
NZ_AP019739.1\|WP_141418398.1\|757090_758551_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	1.4218e-32
NZ_AP019739.1\|WP_141418392.1\|737017_738070_+\|helix-hairpin-helix-domain-containing-protein	gnl\|CDD\|378965	pfam12836, HHH_3, Helix-hairpin-helix motif. The HhH domain is a short DNA-binding domain.	5.96911e-13
NZ_AP019739.1\|WP_019130094.1\|758588_759986_+\|PKD-domain-containing-protein	gnl\|CDD\|176509	cd08566, GDPD_AtGDE_like, Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase (AtGDE, EC 3.1.4.46) and its uncharacterized eukaryotic homolgoues. Members in this family shows high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. AtGDE exists as a hexamer that is a trimer of dimers, which is unique among current known GDPD family members. However, it remains unclear if the hexamer plays a physiological role in AtGDE enzymatic function.	7.6486e-53
NZ_AP019739.1\|WP_141418396.1\|746202_747084_+\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	2.12001e-29
NZ_AP019739.1\|WP_034780076.1\|748001_748802_-\|energy-transducer-TonB	gnl\|CDD\|273570	TIGR01352, Protein_TonB, TonB family C-terminal domain. This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds].	0.000330974

>NZ_AP019739.1|WP_141418395.1|744121_745801_-|alpha-amylase
MKRTLLTLAAALFLLPASAQQVPEWLKEGILYHIYPSSFKDSDGDGIGDLEGIRSKLPYVKSLGANTIWLSPVFRSEFEDGGYDITDFYRIDPRFGTNSQLVQLVREAHDLGIRVCLDLVAGHTSDKHPWFRQSSEADPELQYSDYYIWSDSKDSFPTKKFVRSDAARDGNYMKNFFDIQPALNYGYLHPDPAQPWQQGYDDPGPTAVRNELKNIISFWMDKGVDGFRCDMAQSLVKGDDKQHTGTMRLWHELRSWFEAKYPEGILISEWSQPRQSLRAGFHIDLLIHNGAGTKIYRTLVCQTDDRGTKETPCFFDYEGRGQVKAFAENYRTEYETTRELGYAAMPTCSHDIWRLNRFDRNTPEQLKTALTLFLTLPAVPILYYGEEIGMRNLEDAPVKEGSYTSRNRSSCRTPMQWDDSPNAGFSTADASRLYLPIDPSPARPTVAAEERDPQSILNYVKGLIALRRQTPALGTQGAWRFVSDVEQPYPMVYARELDGQKYLVALNPSKRSATARFASEGAAAEAVYGTGDGAKYTSKNGLSTLKMKPVSAVILKITE
>NZ_AP019739.1|WP_141418394.1|742735_744025_-|histidine-phosphatase-family-protein
MKRQTILLLLSVLLLSGGAAAQSTKEQTLEDLNRTAALYYCYENHPRAAATPAPEGYEPFYISHYGRHGSRWHASESVYENPRAKLRKAAEAGKLTPLGEEALRRIEVVADDARHRYGDLSPRGVREHRGIAERMYCSFPEIFSTADGRLCRIRARSTLVPRCMLSMAAANERLKELNPAIDITREASKRYLDYMFRMTEANKIKKEIKQRIAELREREIDPSRFVRALVTDPSLVGNRKEQLRFMNDLYCVASVMQDVDYLDCSFYDLFTPDELYAFYAVRNYQMYLEEGPSAEFGHRALSDAVPLLRNFVAEADEAIATGALSASLRYGHDVNVIPLVGLMGIEGCDTRESDYRKVDQAWSCWRVTPMATNIQLVFFRRPDGGDVLVKFLFNERESRIRLESDLAPYYRWNDVKRYFDERIATQTRQ
>NZ_AP019739.1|WP_141418393.1|738712_742507_+|leucine-rich-repeat-protein
MKKMFALAAVLCLALAGCEYDDAEVKDRLDDLEGRVDALEKTVNSLNINVGNLQSLIDGKLFITAVTENPEGGGYTLSLVTSDGEASQIVIKDGEAGAAPAIGVKLDSDGKYYWTLDGEFITEGGKKMPVTGDDGVTPVFKIENDTWYVSYDKEATWKECGPATGAAGDSFFSDVSTSEDGRWVYLTLADGETVLTLEMYKEFGIAFESLPELIMAGATAEIPFVLTGADEKSVVEAIAKGDWEAEAVMDGTEGGKIVVTAPAESSTGRVIVLLSDGESKTIMKTLTFVSGVMNVTTQSQEAAAVGGTVSFELETDLDYEVVIPDDAKEWLSRVETRALRQETLTFSAKANETMEERQAKIELISSGVVVETLLVYQKANLDPTAFVVKVNVTESSMKNTLILPLTGTVDATVDWGDGKTETVTAVNPQHVYEQEGEYYVTVTGSVTALGNRLTKTSQSAIVRVIQWGQLGLESLEEAFYNNKGLTQVALPDAGAFAKVTTVENMFYNCTLLTAVPVGLIDQCTELTSAASLFSGCSSLTSIPEGFFDNCPKIASLASAFKGCKKVTEIPAGLFDNLTEVTDVSGLFTNCTALVSVPDGLLDKLTKVTTVSSFFNGCSSLRTVPNDFFKSQTEVTASGMIFKGCSSLESVPSGLLDPFTKTTTIGSLFSGCKSLGNLPEGLFDKVGSNVDPSAKAVDASYLFENCVKMTDFPSLSKLPNVSNVASLWRGCTAMTTVPADYFPSSCTNSISVGNMFNGCTSLKSLPAGLLKNMTDITTALSMFTNCSSLETLPEGFFDAMVGCTNIKEMFKGCTSLESLPAGLFDKMTSITATASAFYGCTGFTGESPYLTAEVEGAPVKVHLYDRPDYPDLFVKVPTKESDYKDTFKNCTKMADYAMIPTAWGGVSDGTKAKPTIALSYALPENMEYHGINFTVKGTEFKSGKYIVGTTELVQSVLDEFDGNMEKATNKYGIGFTATQLETLMSDAGLQLPFNDLEPETEYMLLVRGQNVHGLTFETLTATTAVRPQGSADYERYIGTWTVTTTSSEVTGQPQTYTIRIEPYRNDKSYKVYDWGATILGTGRPATEETDEMEAFPFYLTYMADGSVEINSFNEVGIYGWASYVYIAYRFLNENSERSIWRTETSLVKGSYDTAKNEITITCDKFTDKAGLTHQITGLDYVLYTSQTGYYEAAEMIRPGYLIGEGDNRRVDYGVGPYKLTKAPAAAAVPAKRPAKKFESLRPASETKQAAAVSLGVGRLSMMSVH
>NZ_AP019739.1|WP_019130109.1|738158_738350_+|30S-ribosomal-protein-S21
MIIMPVKEGENIEKALKKFKRKYERTGVLKELRRRQYFTKPSIAKREAMQHAIYVAHMNRDDE
>NZ_AP019739.1|WP_141418392.1|737017_738070_+|helix-hairpin-helix-domain-containing-protein
MWSREDRRTLVLLLPLLVLAVAAFLLLEPKTPRSGAPPDAAKEAPPELFEFDPNTVDYRALRRLGFTKQDAAGVLRYRAAGKIFRIPEDFAACYQVSDSMYDRLEPYIRIGAEYRFRPRRDSAQRLRKPFMRRQRVVVPLVPFRIDTMTAKFLRAIGFTKRQAEAIADYNTLIGGFRDEEELCDYPIIGDSAGRRLAEYALFPERRRPLHDPVELNTADSAALRSVSGIGAKTVGAILDYRRRLGGFCRAEQLAEVRGVTESNYERILKQISIDSCRISKIDINFATPKALAEHPYIAPRTLRKILKRRQLKGGWSTLEEMIEDGILTREEADRLHPYLRFGVRTTQNDD
>NZ_AP019739.1|WP_141418391.1|735173_737018_+|menaquinone-biosynthesis-decarboxylase
MSYNNLREFIERLEREGELVRVAAEVSPVEEIAELTDRMAKQPGGGKAILFERTGTDFPVVTNLMGSERRMVLALGVESLDGLTRRIDTLLHEVTTPKATLWEKLRMLPLLGEMARWMPRSRRGRGPCQEVVLRGEAARLSLLPVLKCWPEDGGRFVTLPMVHTLDPDTGVRNVGMYRMQVFDDRTTGMHWHVHKTGARHYDSYRRQGRRMPVAVALGGDPVYAYAATAPMPDNMDEYLLAGFLRRRPVELVRCLTCGIEVPADCDFVIEGYVDPAEEKTVEGPFGDHTGFYSLEDRYPRFHVTAITHRRDAVYPATVVGVPPEEDAYIAEATERIFLAPIRLAVQPEVRDLWMPTAGTAHNLAVVAIERRYEGQAHKVAQSLWGAGQMMFNKYLVVADAATEIRRVEALAALVRRLDPARDLIAAEGVLDVLDHATATSGFGGKLALDLTRAAAREEPPLQLPERFEPCGGVAAAATGFAERWRTLALFVDRRTERVDAAAFFGRNPVRGVKCAVLFDREAEGLTGAELLWLAAADSDPRRDVTVVGEVVVVDARSKRLGVEGHPARFPNVAVASSATVERVDARWAEYGLGETMASPSERYRRLLLSDKAAW
>NZ_AP019739.1|WP_019130112.1|734726_734921_-|hypothetical-protein
MPRRSIFGEAKVRKVECRSKRQLDYAETKRKNNLRRLCAARVEASARGGPPMTFSAGFAPQRTE
>NZ_AP019739.1|WP_019130113.1|732295_734428_+|methylmalonyl-CoA-mutase
MRAKFSELSYTGAAPKCCAQAGGEKEPWLTAEQIPVKGCYSAADLEGMEHLNYAAGVAPFLRGPYSTMYVMRPWTIRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLATHRGYDADHPRVVGDVGKAGVSICSVEDMKVLFNGIPLDKMSVSMTMNGAVLPILAFYIVAGLEQGCTLDQMAGTIQNDILKEFMVRNTYIYPPEFSMRIIADIFEYTSKNMPKFNSISISGYHMQEAGATADIELAYTLADGLEYLRAGVNAGMSVDAFAPRLSFFWAIGMNHFMEIAKMRAARMLWAKIVKQFDPKNPKSLALRTHSQTSGWSLTEQDPFNNVARTAIEAMGAALGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQEETNICRQVDPWAGSYYVESLTEEIAQKAWEHIQEVEKLGGMAKAIETGIPKMRIEEASARKQARIDSGVEKIIGVNEYRLDKEAPIDILAVDNTAVRESQIKRLKELRASRDEAAVQKALAAITECVKTKQGNLLELAVEAAKVRATLGEISDACEVVVGRYKAVIRSISGVYSSEVKNDTQFEKAKELCARFAKKEGRQPRIMIAKLGQDGHDRGAKVVATGYADIGFDVDMGPLFQTPAEAAKQAVENDVHVVGVSSLAAGHLTLVPQIIAELKKLGREDIVVIVGGVIPAQDYDELYRDGAAAIFGPGTPIATAAIKILEILMGE
>NZ_AP019739.1|WP_141412892.1|730441_732283_+|methylmalonyl-CoA-mutase-small-subunit
MANTKREKLFAEFPPVPTEKWEEVIAVDLKGADYERKLVWRTPEGFNVRPYYRAENLEGLKFLASEPGEFPYVRGTRCDNVWRVHQSLTVKCPEAANAEALKLLDSGVDSLGFSLTKGLSAAEVETLLRDIHLPAVEVVFSGEGVADVVEPVLAKIEKEGWQETASVHFVLDPIINRLSLTGAFCSPGGEKCFKMLAGLVRRTAAMKGVRVVTVSGENFSNAGSTIVEELAFTLSAGHEYLVRLMDEGLTVDEAARKIRFSMGVTSNYFMEMAKFRAARMLWANIVKGYNPEKGCSCKLFAHAVTSTWNQTVYDPYINMLRGTTEAMSAAIAGVHSLEVTPFNASFAEPDEFSKRIARNVELLLKHESHFDQVVDPAGGSYYIENLTQSIAAEAWKLFLELEEKGGYVAAFESGYVVERVDASAAAKDKSVAQRRITLLGANQYPNFTEVASDAVTEAAVTRRKKAGVLNPYRGAMAFEAMRLHVDRSGKTPKAFMLTAGHLAMARARAQFSCNFFACAGIRVQDNTFFKDLEEGVKAALESKAEIVVLCSSDDCYAELAPRVKEMLGDKAILVIAGAPACMAELEAQGIGNFIHVKSNVLDTLHNYLTQMGI
>NZ_AP019739.1|WP_141418390.1|729928_730285_+|hypothetical-protein
MKKNRTFSEKQRCFLAMKTEISRVFRKNALVFWRNPIFRENRFFAKFRDKQDNIDLNIVFAAPLSGGSFRPAGPAMRPAPETVRRTRPAVSAAAGRLPYAARDGAGLSGRLRGAVLKN
>NZ_AP019739.1|WP_141418396.1|746202_747084_+|prolyl-oligopeptidase-family-serine-peptidase
MKRLTILATLLFAAVSVSAQDYHIKLWDNTTAPTSNGVTGDEYERKPGTLTNTSSAEIWIYKPAPEKATGQAIVFCPGGGYSQLSIANGHNTCKWFAENGIVGVMLKYRLPNGHSEVPLNDLDKAVATVREMAGELGVDPHKVGVAGTSAGGYLAGSAGVMSESKPDFMVLIYPVVSSDPDKRHLGTFQQLVGKENVETEAAKFSLEKVVDSTACPALIFHSDDDKVVPAINAALLYEKLKANGVKASLHIFPSGGHGWGMSKKFKYHENFKAATLDWLKVINAEADKAAAKK
>NZ_AP019739.1|WP_162502162.1|747421_747769_-|DUF3795-domain-containing-protein
MKRLIACCGLDCEHCDARRATIDNDDALRERTARKWSEMNDAPQITAATIHCTGCRTEGVKFAYCSDLCRIRKCVSEKGLSTCGDCREVDACPIVGAIFRHAPDARENLRVPATS
>NZ_AP019739.1|WP_034780076.1|748001_748802_-|energy-transducer-TonB
MSTQETKPEPRRPKLRLPFDNRREDAGEWAFDHRAGLCVTLIAYLLLAIAFVGAKIVVGGRPAAQGFYIDLQQLEQLAAEKERLEREVRRRQQQEPIDWKSIRNDVSNENAKLDESLRDDRGTNTAALNDAADAAQERMRANREAYERGLAEAEAIRRRRERTDERGENSDRKVQGRVTVSFSLVDPVRHARHLVVPAYQCEGGGEVVVRITVNRAGEVTHASVASGGDDCMRETAVRAARNSVFDINDAAPARHTGTITYIFIPQ
>NZ_AP019739.1|WP_019130100.1|748885_750277_+|bifunctional-UDP-3-O-[3-hydroxymyristoyl]-N-acetylglucosamine-deacetylase/3-hydroxyacyl-ACP-dehydratase
MSTKQQTLKGPISFSGKGLHTGVEVTMTVNPAGVDNGIVFRRIDVEGTPLVPALCDNVTDTSRGTTIESNGVKVSTIEHIMSALWTLGVDNALIDIDAAEAPIMDGSAREYAEKIVATGLVEQDADRKYYQVTEKMVYTIPDKGVSIILYPDEEFSASVHVDYNSKVIGNQYATFLPDDDYAAKIAPCRTFVFLHELEPLFKMNLIKGGDLDNAIVVVENPVSDEQLTHLKQIFHKEDICITGGYLNNLELRFTNELARHKLLDLLGDLALLGMRIKGRVWASRPGHFANTEFMKQLRRTIRKEGERPRYKYDCRKTPVYDINDIRRMLPHRPPFLLVDRIFHVDDNSIAGIKNVTMNEPFFVGHFPNEPVMPGVLIVEAMAQCGGIMVLRNIPDPENYSTYFMKIDGVKFKRKIIPGDTLQFELHLTEPIRRGVCVMDAKAFVGDTLACEATLMAQVAKTKK
>NZ_AP019739.1|WP_019130099.1|750347_751127_+|acyl-ACP--UDP-N-acetylglucosamine-O-acyltransferase
MISKLAYVHPDAKIGGNVTIEPFAYVAGDVVIGDDCWIGPGAVINDGARIGKGCKIHTGASIACLPQDLKFKGEYSTAEIGDYNDIRECVTIARGTASRGKTVVGSHNLLMAYVHIAHDDVVGSHCVIANRVSLAGEVEVGDWAVIGGHAAVHQWVRIGEHTMIQGGALVGQDVPPFITVTNENQFAGINRIGMSRRGFTPEQIDIIHNAARILFQSGLNFMNGCEEVERKVLQSPERDRLVKFIRESKRGVSKQYGVK
>NZ_AP019739.1|WP_026074832.1|751725_752280_+|RNA-polymerase-sigma-70-factor
MDRKSDELILQGLRQGDCKAFDELYMRYAPRVEAFACCMLKSRSEAEDLAHDIFLKIWENRRSIGHIRSLGNYLFRMTKNAVFDRFEHKSVQVRYERQCLAAGDFLSDDVAAKIASEDLLMIVELAVERMPEQRQRVFRLSRYERLSHQEIARELGITTKTVEYHIRTALAELRKIIAAIIVFF
>NZ_AP019739.1|WP_141419624.1|752418_753399_+|DUF4974-domain-containing-protein
MVRKIIRAYLYNPMPEKVQRQFRSWCLREEGSHEKTEALREEWERLDPAAVLPTDEEAYRGKLARLHGEMRPPLRLRTIPLSRRAAAVAAAVVVLAMSVEFFVVRHLTADSTTVLVTAENSKGRFTLPDGSVVWLNADSRLAYSNRFVDSEKREVRLEGEAFFDVRRDTLRPFEVTMGDLEVRVLGTRFNASHIPDLGIEEVTLLSGSVEVGHDGSRETVRLLPDQSCAYDTVSGRLAVRNVRASNYGSWTGDSIVFDNMTLEDIAVNLEHWYNIRIRIDDGVDASTRISFTLRPETLDETLRIIENLTHFACERTDRQHITIRKR
>NZ_AP019739.1|WP_141418398.1|757090_758551_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKIKQIFAVLAVSASLMSCNFLDEFDPNATTAGNFYTSEADIETSLNGVYQSLAQSYYYQYNYYFTDVRAHVTVVTDSGASSGIPYQFYNYTLTEENQYVYNRYTQLFKSISRVNTLLSHLDDVTYSASEARDTYEAEARFVRALTYFHLVTEWGDVPLVLERLDSKDEVAANNYRRPKAQIYKAIFDDLDFVLDSPLADFQPASECGRASKAAALALYGKAALQCACDEDFASEKSSYLTTAIEKLTSVWGMRPFGELSEIPYNQIWDLSTQKSCPENIFQINYVQGNADLGSIWNYQFGPSTTGVTSYKIGQMHNMTTGEVYESFDPGDVRRNYLRATTVAGVTYYHTMKYADLECGANGYGGNNWIVLRYADVALMLAEAYYWQGVSPTAETYLNMVRRRAGLADWSGSDLRQGIYDERLFEFIQEGLRWQDVLRMYSNEEMIEHYNAINSNFSVKDLLLPIPYNERILNPEGLYQNPGYGVE
>NZ_AP019739.1|WP_019130094.1|758588_759986_+|PKD-domain-containing-protein
MLWIAGLALIAACSDGGGEERPGPQQTALSIVWTPEAPAAGQSVRFSLGGDVSNVRSVLWMFGDGKTSSAAAGGEVDHAYAAAGDYTVKAAVTPVAGSMSELSRSISVSDTEAAMVVSNDFPACREEVVFSLNRMTGVTGVSWDFGDGSERRQTASASETLTHSYAEEGRYTVRAEVAYADGGTETLMRQIEAAGLSLSWACRNFDPSKMWIMAHRGNTKNGYELPPNSMAAFRRCVELGCVEFIETDVQITKDGEVICLHDNYLSRFTDYNDYASGKGLVADFTLEELGRFRLKTTDGKVSDQKIPTLEEVLMEFRGKVWFNLDKCMESDVSIEKVYDVVERCGCLDRVQFYISDDTDRADWLSRQKPQGIIAPHANKEEVLTRMAAYSPVYMIQTSTQYAGASWISSINARALSVTNLLDDEGQAFYNGNTTVMDGFVSAGVRMIQCDYPAEMDEYLRGRGKR
>NZ_AP019739.1|WP_141412901.1|760012_761875_+|PKD-domain-containing-protein
MKRILSILSVATLFVLIGCTDSNDDMEIVYDSIIEPDFTVAAAEIVAGVTPVTFTNTTSVEGTTVAEYFWHFGFSGEGNWSEEAEPDPIVYNQAGEYTVTLTAWGADGNRATVKKVVTVLADNVVPTADFSYSPMMVNVGDEVTFTDKSTDSDGEIVSREWVFPDGSTSTETNPSYTFTQKGMFQVKLTVADDRGGESSATKSINVRDGDVSDFTLLWSTEVASADALCDANVVTVSDLGYVYAVTGDGKLVALDAEGAVAWEYDAAAQDKVNLRKEIAYPSVDADGTVYWVAHAYGDDSAVPTVYAFEGSTGSVLWKNQTAYAAGARIAFSTPSVGPNMVVVGSRGTNGAIRGFEKSSGRNTAQATPANGGGTSGTIVLKNGVVIFTNTGEYGYGIMVPDDQFVWSPVPTADTFAPGKTLSAGRCQPCVGADNCVYLPGKIKEGSGGSWNIACFDCTNLTASSTKTPKWSVAVPDGFVQGGASLSADGQTLYIVADAATPSTVYALSTSNGSTVWSYPLDAHCNSVPAVDNLGQVHVATETGHYVVLSPDGKPVYDEQIADMFEGSVSISEWGYSYVLGKDASAGKLKVYAVALPGVNSAAASAWSQYGRNARHINYQQ

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Crispr_ID: NZ_AP019739_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_7

1126528-1126627

Orphan

Consensus_repeat	Method
CGCCGAAGATACTCCCGCTCGGCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_7

>merge|NZ_AP019739|7|1126528-1126627|CRISPRCasFinder
CGCCGAAGATACTCCCGCTCGGCAAATCGCAAACTGTGTTTGCATTTGCTCTCACTTATTCGTATCTTTGGCTGACGCCGAAGATACTCCCGCTCGGCAA

>NZ_AP019739|7|6|1126528-1126627|CRISPRCasFinder
CGCCGAAGATACTCCCGCTCGGCAA	ATCGCAAACTGTGTTTGCATTTGCTCTCACTTATTCGTATCTTTGGCTGA
CGCCGAAGATACTCCCGCTCGGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019129839.1\|1146390_1147350_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133030
NZ_AP019739.1\|WP_141418535.1\|1125307_1126420_+\|DoxX-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418542.1\|1141912_1145662_-\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NZ_AP019739.1\|WP_141418531.1\|1119303_1119891_-\|phosphoglycerate-mutase-family-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418534.1\|1124619_1125315_+\|thymidylate-kinase	unknown	unknown	gnl\|CDD\|236133
NZ_AP019739.1\|WP_141419637.1\|1126766_1129736_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_AP019739.1\|WP_141418529.1\|1115996_1116875_+\|fimbrillin-family-protein	unknown	unknown	gnl\|CDD\|372499
NZ_AP019739.1\|WP_141418538.1\|1131871_1135207_-\|fimbrillin-family-protein	unknown	unknown	gnl\|CDD\|240525
NZ_AP019739.1\|WP_141413101.1\|1123136_1124354_+\|SufS-family-cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_AP019739.1\|WP_162851478.1\|1145912_1146380_-\|DUF4293-family-protein	unknown	unknown	gnl\|CDD\|379484
NZ_AP019739.1\|WP_162502166.1\|1117445_1117622_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418532.1\|1121560_1122316_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|273907
NZ_AP019739.1\|WP_019129854.1\|1120094_1121537_+\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|236990
NZ_AP019739.1\|WP_141418540.1\|1139500_1140541_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197338
NZ_AP019739.1\|WP_141418533.1\|1122315_1123134_+\|SufD-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|376550
NZ_AP019739.1\|WP_141418537.1\|1129738_1131637_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418530.1\|1117915_1118359_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371505
NZ_AP019739.1\|WP_141418539.1\|1136708_1139489_-\|TonB-dependent-receptor-plug-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NZ_AP019739.1\|WP_162502167.1\|1140632_1141853_-\|DNA/RNA-non-specific-endonuclease	unknown	unknown	gnl\|CDD\|366523
NZ_AP019739.1\|WP_141413106.1\|1135585_1136605_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_019129839.1\|1146390_1147350_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|133030	cd04187, DPM1_like_bac, Bacterial DPM1_like enzymes are related to eukaryotic DPM1. A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.	2.68122e-83
NZ_AP019739.1\|WP_141419637.1\|1126766_1129736_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	5.90587e-10
NZ_AP019739.1\|WP_141418542.1\|1141912_1145662_-\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	0.00103675
NZ_AP019739.1\|WP_162851478.1\|1145912_1146380_-\|DUF4293-family-protein	gnl\|CDD\|379484	pfam14126, DUF4293, Domain of unknown function (DUF4293). This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 154 amino acids in length.	1.61168e-36
NZ_AP019739.1\|WP_141418534.1\|1124619_1125315_+\|thymidylate-kinase	gnl\|CDD\|236133	PRK07933, PRK07933, dTMP kinase.	1.43945e-38
NZ_AP019739.1\|WP_141418529.1\|1115996_1116875_+\|fimbrillin-family-protein	gnl\|CDD\|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	7.18773e-21
NZ_AP019739.1\|WP_141413101.1\|1123136_1124354_+\|SufS-family-cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_AP019739.1\|WP_141418532.1\|1121560_1122316_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|273907	TIGR01978, Probable_ATP-dependent_transporter_SufC, FeS assembly ATPase SufC. SufC is part of the SUF system, shown in E. coli to consist of six proteins and believed to act in Fe-S cluster formation during oxidative stress. SufC forms a complex with SufB and SufD. SufC belongs to the ATP-binding cassette transporter family (pfam00005) but is no longer thought to be part of a transporter. The complex is reported as cytosolic () or associated with the membrane (). The SUF system also includes a cysteine desulfurase (SufS, enhanced by SufE) and a probable iron-sulfur cluster assembly scaffold protein, SufA. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.63265e-139
NZ_AP019739.1\|WP_019129854.1\|1120094_1121537_+\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|236990	PRK11814, PRK11814, cysteine desulfurase activator complex subunit SufB; Provisional.	0
NZ_AP019739.1\|WP_141418540.1\|1139500_1140541_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197338	cd10283, MnuA_DNase1-like, Mycoplasma pulmonis MnuA nuclease-like. This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.	1.05166e-08
NZ_AP019739.1\|WP_141418533.1\|1122315_1123134_+\|SufD-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|376550	pfam01458, UPF0051, Uncharacterized protein family (UPF0051).	4.31276e-65
NZ_AP019739.1\|WP_141418538.1\|1131871_1135207_-\|fimbrillin-family-protein	gnl\|CDD\|240525	cd13120, BF2867_like_N, N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins. Two structurally similar domains with low sequence similarity in a tandem repeat arrangement form a protein that may have a role in cell adhesion. This family overlaps with DUF3988.	0.000748789
NZ_AP019739.1\|WP_141418530.1\|1117915_1118359_+\|hypothetical-protein	gnl\|CDD\|371505	pfam11396, PepSY_like, Putative beta-lactamase-inhibitor-like, PepSY-like. This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.	6.95158e-22
NZ_AP019739.1\|WP_141418539.1\|1136708_1139489_-\|TonB-dependent-receptor-plug-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	1.59363e-09
NZ_AP019739.1\|WP_162502167.1\|1140632_1141853_-\|DNA/RNA-non-specific-endonuclease	gnl\|CDD\|366523	pfam01223, Endonuclease_NS, DNA/RNA non-specific endonuclease.	1.56999e-37

>NZ_AP019739.1|WP_141418535.1|1125307_1126420_+|DoxX-protein
MRNRAFKWLSHACRIVLGVTFIFSGFVKTVDPWGTAIKIQEYLSIYGLESLSGLRFGFSIWLCGAELMMGLMLLFKVRIRLISIFALASMIFFTVLTFLSATWLPVEDCGCFGDAVKLTPWETFAKNLVLLPLSVVVWWRYRRDRIFAFSKAEVGCTVLFFSLAMGLGIYCYAHLPLIDFRPFKVGVNIYEAMNAYSADPGPQAGKTVLIYRNRQTGRLHEFSLDDTEWQDAGRWEWVDTRTEELDEPKVDPTLSEFSLRDAEGDATESLLTRPGRVYMLCITDSEGLDAPCERRFRGVVERAAAEGALAVCLTPERLRGVTYRSFAGSAAVRCYNIDATTLKTMLRAFNGMVVLDDGTIVEKRNCRDIR
>NZ_AP019739.1|WP_141418534.1|1124619_1125315_+|thymidylate-kinase
MFIVLEGLDGAGKSTQIRMLQELFARRGVACRYLHFPRFDAPVFGDLIARFLRGELGTVEAVDPYLVALLFAGDRGDAAAEIRQWLASGEAVVLDRYVYSNVAFQCAKLSSEDERRALKRWILDTEYGYYRLPRPDVSLFLDVPFSFTERKLTQAREGGDRDYLQGAHDIHEASLDLQQRVRGVYLDAAREDAAFRVVDCCAPDGSMETPERIFSKIEAALAPLLNAAADA
>NZ_AP019739.1|WP_141413101.1|1123136_1124354_+|SufS-family-cysteine-desulfurase
MFDVEKIRADFPLLSTEVYGRPLVYLDSGATAQKPRCVIDTVDYLHRELNANIHRGVHRLAEEATERYEAARDRIRAFIGAAHREEVIFTAGATASLNTVAYAWGDTFLRAGDNIVVSEMEHHSNLVPWQAVALRKGAELRMLPFDDAGRLMTERLDGLIDGRTRMVAVTQASNTLGTRPDLRPIVEAAHAVGALVCVDGCQGIVHGGADVAALGCDFYAFSGHKLYGPTGIGVLYGRRELLDAMPPFLYGGDMVDRVSFGGTTYAPLPLKFEAGTANFVGAIGLGEAIRYLEQFDPAEIEAYERELLGYAAERLSAVDGLRIYGATPDKCAIVSFTVEGTHPYDVGMILDKLGIAVRTGQHCAEPVMTHYGVPGMCRASLAMYNTRGEIDALAAGVERAVRMLR
>NZ_AP019739.1|WP_141418533.1|1122315_1123134_+|SufD-family-Fe-S-cluster-assembly-protein
MERLDWIEGEGFEALRGQRAALVDGPVYTLLDPTEYAVAVGEGDRARLVIVHTKPESATLSIDVGENAKLSIVEMFIDEAFVECSIRQQGGSLCEVTMAELTSANVSYRIDLDGAFARSELDGLFLAADKEHCEVGVRVSHNVPDCSSRSLVKGVAGGEATGAFQGLVYVAPGAQRTDAQQTSRNVELSTGARIVAKPQLEIYADDVKCTHGATVGQMDDEAILYMRQRGLSEQQARRLQMEGFVAAIAAHCAVEPLCEELYRRIVAKLERM
>NZ_AP019739.1|WP_141418532.1|1121560_1122316_+|Fe-S-cluster-assembly-ATPase-SufC
MLSVKNLHASVDDKEILRGIDLDVKAGEVHAIMGPNGSGKSTLASVLAGNEKFTVTAGSATFQGHDLLAMSIEDRARLGLFLGFQYPVEIPGVSMANFMKMAVQEQRKYRGEEPLTASQFLRLMKEKSAVVELDPKLMSRSVNEGFSGGEKKKNEIFQMAVLAPKLAILDETDSGLDIDALRIVATGVTKLRTSENATVVITHYQRLLDYIVPDYVHVLYKGRIIHSGDKSLALKLEKEGYDWLINDYREA
>NZ_AP019739.1|WP_019129854.1|1120094_1121537_+|Fe-S-cluster-assembly-protein-SufB
MSEQDNIIKEIEGREYKYGFTSDIETETIPRGLSEEVVRLISAKKGEPEWMTESRLRAYRHWLKMEPPTWAHLRIPEIDFQDIIYYAAPRVRPKLGSMDEVDPELKRTFDKLGIPLEEQMQLAGVAVDAVMDSVSVKTTFKETLSEKGIIFCSISEAIRDYPDLIKKYLGSVVPCTDNYYAALNAAVFSDGSFCYIPKGVRCPMELSTYFRINAEGTGQFERTLIVADEGAYVSYLEGCTAPRRDENQLHAAVVEIVVERDAEVKYSTVQNWYPGDKEGRGGIYNFVTKRGLCRQNARLSWTQVETGSAITWKYPSCVLLGDNSVGEFYSVAMTNHFQQADTGTKMIHIGRNTRSRIVSKGISAGRSENSYRGLVKVARSAEGARNYSQCDSLLIGSACGAHTFPEIACSNRTAIVEHEATTSKISDEQLFYCNQRGLSTEDAVGLIVNGFAKEVMAKLPMEFAVEAQKLLSISLEGSVG
>NZ_AP019739.1|WP_141418531.1|1119303_1119891_-|phosphoglycerate-mutase-family-protein
MDTIERIARRNRLRAEEVIRDSRLAEIWRSVGAEVRQVGSLRSGLLMKHRDIDFHIYSSPLRMEESFAAMAQLAADPAVGRIECRNLLATDEACVEWHATYRDRDGDEWQLDMIHIVRGSRYDGYFERVADRIAATLTPVTRRAILQLKYDTPDDVKIAGIEYYVAVLRDGVRTYDAFAEWRRTHPLTGIVEWMP
>NZ_AP019739.1|WP_141418530.1|1117915_1118359_+|hypothetical-protein
MKKTFLTLFLMTTMFGAAYADGREKPTSVDKLPQAAQEFLSAHFKDLTVAYAVEEQKYTGKEYEVVYTDRTEIEFRSDGQWESVGRKYSPVPASIVPQPIQTFVSGSNYPGQFIRQIDRNAYTWEVELSNGLEIKFDNQFNVIDIDD
>NZ_AP019739.1|WP_162502166.1|1117445_1117622_+|hypothetical-protein
MNPNDFSQHSGTAGGEHIGLLYMEIVCLEDGGTYTESSVPGSYMPIQRIEVCTIGQDA
>NZ_AP019739.1|WP_141418529.1|1115996_1116875_+|fimbrillin-family-protein
MNKTFFTAAVLLVLVGCNDDKEQTKPAPGEGKITVTAGIDALTRAPHLNEDGSGYFQDGDKIALTVTGGDKTVRKEYTIGGAALYWEDLGLPSGTTEASFAGCYPAPESAEGSEFTFDLSTAADKDLLLAPAMKVSKSADTKVNLAFKHAMHKLAINYASDGTYTQEQLEAVKTTCTAKSSCEVNMAAATVSKTADKTAAFEAAGKAVRFLLVPQTSEEVTLKIEIGGKTVEHTLAGLNEVLKNATQEIPAALDGGKCLTLNLTFGKDGIVVEGSQIGGWEDQGTVDGDISM
>NZ_AP019739.1|WP_141419637.1|1126766_1129736_+|tetratricopeptide-repeat-protein
MIAALGCLWCGADASVLTSGGRTHFDRGRELYALGRWADAREEFAAVCGAVPQTESSLCAEADYYMAMCAMELKEAGAEARLAEFLRRNPESVHVNDVEFALASLLCTAGRYDEAQRAFGKVDYATLSPEHRQQYDIRMGYIRFQQGDYDDALRYFRRIPSPGEYSDHALYYISYIAYVRGDNATARAGFTELSRSAAYGAVAPFYLLQIEFNEGNYRYVVTTGGSLIDRAAGERRTELERIVAEGWFHLGDYGRTEEFLDAYRRSGGEMGRNENYLLGYSLYRQARYDEARPCLQQVCGADDALTQNASYHLADCYLRGGDKQRAMQSFAMAANEAFDAAIAEDALFNYGKLQYELGGGLFNEAIHVLNRYIAQYPTSERAVQARELLIAAYYNSRNYEAAYTALKHYPSPDGNLRAALQKIAYFRGLEAYSRGDLDGAAQSLSESAAINVSPKYGALARFWLGEIAFARGDYAEAERRYKEYLHRAPRTEDEYAKAHYNLGYCYFDRGDMSNAYASFARFNQLYSAADRYKADALNREADARYSLRQFSAALATYEKAAAVGTNEKYYADFQRAVTLGILDRRPQKIEALQRIIAADRGDYVDDATYELGRTYIASERYDDGAKVLSKFVEENPHSPFFTPALSDLGLAYLNLGQPELSRRCYERVVESAPGSATARDALQGIREIYVADGNVDGYFAYAEKAGVECDTSVMARDSLSFAAARRIYLSGDTATAEKSLRSYLRNYPKGYYTDDALFYLSDCHLKAKQTDAAIETLSELAARPTNQYSARTLGTLSKLTSEAGRHAEAAKAYRALYDVVQTADERAAAATGYFRSVEAGGDDAATLAAAAEVEALPDAGATVQREAKFARATILRRGGRQAEALPLYRELSREVRTAEGAESAYRVIEATLGGGDAAAAETLIFAFAEKGSPHAYWVAKAYIALGDIYAGRDDSFQARATYQSIVDGYSPADDGIVAEAKARIEKLKK
>NZ_AP019739.1|WP_141418537.1|1129738_1131637_+|hypothetical-protein
MKRVLILSAAVLFCGVPLRAQVTKQVEVTKTYVPEVSKAVKLPIVPDMTDTVRLRPEIDYTVTPSALATNLSTEPFRPATVTYWEFNRPRPLYLKVGAGAPLNSVLDLYASTQNPGTGYAVGYLNHTGDWAEIRNDFGVRPVSWRMHNRMGAAAGKYLGRRLLEGKLDLTNRVYHNYGFDGAEALCTRYGNDGAASYYPLTKVSNDRQHYDDAMLHVRIGDDFTDLSRFNFNVELRGGYFLNVLQMQPVYYDWGVDRDRYHELSGGGGIRLARAFGLHEFEFKADFDGAWRNMLGYGSTQLLFGLHYAYRHDKLRWSVGLDYVRDGAEQEKVVGSDLSDPHAVYKESQTEHENRFLPAASIAYDPADGKFMLYAELTGKVRRNDMRTLSRLNPYVNPASIVPNTEEHRVAGGIKGAAGHGRFSYNLYVGYTHEKNALQWVARFIPNNVRDERADVGYMSFYIPYTMTLKDLSLNAEFAWRPSSRLTFDGELHMHSFKGAEDVYYNNNQPYTLAYGRPQLTARLRGEYRARKVSLEVEAQMQSVRHWTTYTSVNEKPSEPDSDSGLNLGRRVIGLYDFKVPVTVDLAARFNWFLSRKVTLFAEGRNLCDAKLYDWAYYRDYGVGFTAGVKLQF
>NZ_AP019739.1|WP_141418538.1|1131871_1135207_-|fimbrillin-family-protein
MKRFVQFLGAATLLLSFTQCSEDATTDSAPSVQGSVKLTASINETRTELSGNDVLWKSNDRLGLFCGTKFVNAPFTTTTGGTTSADFTGDPTDPSGSEAEVFYAYYPYSAHAVLEGSVVSGLSIPAVQTFATKSFATELCPMATSGADYSRLAFRTIGTVLKFQVTGQKNVTKIELTGNDGEALAGDYTIDFVGETPEMKFSGTETTLTLTCPEPVALNDASATEFYFVLPAGVEFTKGITVKVYTDDNAEPMVKEYASPLTTRPNKLVTVKAFTYSVPVTSIEEANEALSKGTSGVTITSTTDLTAPSTLEIPNAFGHGTSTSVEIEQPVSTDLTISEKTTSDKELPETLSVEMETTASLIVDTPNLTVSLEGSYTAVEATTAENTLIVAKNTVIETLTVKKGNVKIYGTVGEIVNEGTGKIIRCIDAQDEVERTLADTRCDHILIEKPAGTLDFGGGTTTKQVCVEASVTIANLIVSPEKEHPVMVSGDNVKLTLDGVKLVCNAAKTYAVNCLDGANPDVTLSNSEIIALGTDCRAVSVVNTRATSDTSYITFDNTQARTSQTAIGNREYTADEIKYFTSRVADGNYYPRGISVGSTGGKVNIALRNNSCIEGFFYGINIAGITEPVDVAIDDSRLDGRAALNVHGQKCIFRVNRSTLVGRNYFGGPTEDFATVVLDRAVATSHSNTVTVADSEIYSYNKPQTATNHQYSIDIRSLHNTVELKGSTRLIEVGSTEYPARLNFMVCYDNSTDNVVNVDPGVTVSGKEGAKVLPATVWDGSSVYAPAADADGDYPIYEAAELKWIADQINSGNYLYLEAKGRYAQVYLMNDIDLNNKPWTPMGCQNHSYTLSGVDKCAFYGEFHGTGHTVSNLNVDIVADAKGFIGKTLGKEASIRELTLKNVAIPLNDDAEIQGKWVGALVGCMGGDTNVSDCHVENVTIHAPGMYRIGGLVGVWTNTSRQNATATVENCSVKDATLTAGYAIGGFMGTIQPQKPAAGYNTIRNCSVENISITHKDQYCWGDDPNYAAYYPETGHYCYSSAPFAGDVNNVNLEKCTVGGSCTIADADGHNTYMSATWTKLPYMGEVGGNACIDGVKVSADPTPAEGYFTK
>NZ_AP019739.1|WP_141413106.1|1135585_1136605_-|hypothetical-protein
MNNILKIALTLAVGIVLAGCYNDFDNPAPAKVYTDKDFTETGAEIISIKDLKAKFYEKWGHDANGLGRRVVIEDDVVIKGKVISSDAEGNVYKSLYIYDGEQAIELRLMNDNYVNYPLGQIVYVKAQGLSLASYRYMLSLGAAPALEPDGTFPNDTPSEHDFSASGNSNIPTTEMVQQYVYRGELDTITEADVTVVDKDNYKTVLNDDLLGCLIRFEGLRSSYTTVDSNTYPNYLENVNGVYTNKYYQDEGLPITWAYNYDNTKYYGSSLFTYETTPTSLESGSYVVRVSGYARFALKELPADNAMVNITAIYTKYSSRTGGFITYQLLVSSYKDIEEL
>NZ_AP019739.1|WP_141418539.1|1136708_1139489_-|TonB-dependent-receptor-plug-domain-containing-protein
MKIKHLLTLLLTMATLPALAQGSGIKGKVVSRGDRAAIEQVKITLTPGERQATSDAEGRFRFDDVASGDYTLTFEADDYEPLEIKVRVDKLTKDVRSIALVPVYTEAFDDSIFAEFDTETANDTQSLPSSLSSSKDVFNNIASYKFGEMRFNLRGYDSQYTNVYFNGIRLNDALTGYTPWSLWSGLNDATRNQENTTGLQAADYGLGGIGGTTNINATASQIRKGLRVSLVNGNSMYRFRAMVSYASGLLDNGWSYAFSVSTRQGGNDWVNGIYYNCFGYYGSVEKRFNERNRLTFTILGAPTERGAQQASTQEVYDLVGNNYYNPNWGYQDGKKRNARVRNNHEPLMVVNYTNTPDDRTKIDAAASFRFGTNGYSALTWKGGADPRPDYYRNLPSYYMANNQFSNAAQIAELWRTSYDTRQINWDRLYDTNYRGEIDEGTYGAGHRSNYMIEERHTDQLDLNLTAQIARTFRDNSRLVAGILYRWNRTEYYDKVKDLLGGDYWVDIDKFAERDFVGEEEKQNDLHYYYEHGHARRVEEGDKFGYDYYANIRQAKLWAMYNFNIAGLDGTIGGEVGQVTMWRDGRYMKGTYPSNSFGNSEALDYFTYQAKLNLAYRFSAAHSVEFNAVALQNAPTFQNSFISPRTRNEVTPGLKAEKIWGVDASYNLSYRGIKARLSGYYTMIHDQTDIISYYDDLQSTFVNFAISGIDKKFFGLEFGMTVPLYMGLSLNGAVSVGQYTYDSNPTFVQLADNSSKILSDVDSSIVYWKDMRVESTPQTAVNVGLSYRSDNNWFASADLNFYDNNYLSMNPLFRTDEVLRAGATNAETAEMIRTMRAQEKFDSAFVLNASLGKNWYIKRNYTLGFSLEVKNILNNQDIKTGGYEQMRLNKIKADESNTSLVTSYERFDPKYFYMFGTTYYLNVYFRF
>NZ_AP019739.1|WP_141418540.1|1139500_1140541_-|endonuclease/exonuclease/phosphatase-family-protein
MRKKLIITAVLASVMVMCFAQKPHKIMFYNMENFFDTIDDPETNDEEFLPDGAKRWNTAKYDKKLRNMERVLFDIAAIDRNYPAVIGVSEIENRSILEDIASTRKLLPARYAICHYDSPDLRGVDVAFLYRPDVFKLEGSADIPVRIASLPNWRTRGIVTMWGTIDDEPFLFMVAHWPSRLGGQAASAFKRNAAAEQMRAIADSVLKVNPATKIVAMGDFNDDPTDESVEVHLGAKAKIKELQPGDFYTPFADMLKAGLGTLAYRDAWNLFDNIVVSENLATGSAGKLKLVKDPYKKTKFYGNIFKPSYLIQQEGQYKGYPLRTFVGNNFQGGFSDHLPVFIYIAK
>NZ_AP019739.1|WP_162502167.1|1140632_1141853_-|DNA/RNA-non-specific-endonuclease
MQTHLLRQWLRLAVAAVAVFFAACGDSDGDAATARVESCELERSSIVGGQIASGEETASLRVIVEVSGSGQLNYTATITSGDWLSLSARDFSAAGRQRQGTVDSGENLLFFYYKANASAQSRIATFTIAFDDGSAPYDFELTQLAPNATDNPYDTPKQWPELPAGKEETDYIYAAHYAKMNLKTVRNYSLCFDKKLRVAHWVAYPLHASYIGSLDRSEAWAPDPKIPQQYQPALWLGGYQNGNVYNRGHQIPSKDRTTVEEMNKQTFYASNMTPQRGQFNQNMWAALEAKVRSYVCPDTLYVVTGCYFANLDESTKDKAGNVCPVPTNYFKVLLRTRDGETGKRITDCKASELKAIGFWVANENGQQLGRQLCRSVAEIEKETGFTFFPDADASVKAQNSPEQWGF
>NZ_AP019739.1|WP_141418542.1|1141912_1145662_-|BACON-domain-containing-protein
MKQLNIWKTSFYTMLAIAAGAFTACVDDDVDKQAPTLELSEEAVAFTGTATEDATVTVRSNRQWTVAYEDEETQKEWMYFKVSGNEVSEGIYNGDGTVKITVGESAQPHMGRLIFTLSNSYGELYRKYLTVTQGNYVPPTVGAVGKLVEYILGNSDLSGAVGSDKAMPLQYSESTIEAVILANDAAGNNNRKLYVGDNNGLERSAIVLYGADFAMANDPVTKYPAGRKVTLNLENAKYYAFNNVRQLTDVVVTVGDEEVELVVPSLSVEKFNTGDYQAQYVKLNNMTPAQSFVGKPWTATESQSVTLNDASGKTLTVYMNKAQFATGFADMYVADKTGTIYGVAETYRENAQLIPTKKADIAALSTDQGGGTDPDPTPGDAIYYESFGTADVSDKPLIADYTGWAKTGSGAGEVSYTGEGNMSIRTSGKLSAGYDGASGKNKAFFGTNNPALIINKIKLDGAQDLQLTFGAQYSKTIDYDAGLYDNEFKPEKFHLALSADGTSWTTVEYTYAQADEFWVFATSKFKLKNKAAYLYVKYAVDEASVFAIDDVTLAEGEGGTEVDLGEGSEEPEPTPGEAITVNELYRLAETVTGKDKLVIDAENNRTLEAVVVTDVDGGNVSANNLMVMTEGATQAKNGILLFSSGQYTNPKDPAFPFKSGDKVRFTLVKGLAKVANFSNCYEVTCESSDAATWLTAEVIGKAQLTPVPLTSIDNLIDYQGMLVTVKNVTSPATAGNWAVGTTTFKVGSSDLTVYVTQDAAGFAGKQYAASKTGDLTGYVSLYKGAVQLCPRNMTDAAAFAEGGTDPEPADPAHIVLDFSRGKDMATPAFPYHDKDDSSSATEGTYTIDGYTYHIKASADGKFYWFYNNYNAGSEYESFYIGKAGAYIELPAISGKALSKVILTGASGASSSSEASITDTAGADIAGGLSQVVGQGTATYELNGTTAGTSYRITVTKNNCQFAKIELFYGEGGGSTPVQPTLSVNPTSLSFAAKDQAKTIACTVANADGYTVGASSSDPANFAASVAGTTVTVTPTENTGSARNATVTVYLTNDGGATKVAAKTVAVTQAAAGGSEPAGDTYDKITKVAELVNGMTGFIGCEPGGTYGLQLVTGFTDYGQGFTAAYTYDETKKTLSLTSGNYTAIEFTFEAVADGFNIKQGDKYLIGTGIIDNGKPKQGLVLADAPAQPWTFTEDASGVIATTSASGTVDGQAFNYPAIYMMCANSASSRFLRPYVQASYGKGFCFFKKN
>NZ_AP019739.1|WP_162851478.1|1145912_1146380_-|DUF4293-family-protein
MMIQRIQTLYLLLAAGLVACAAFLPLASFASGGEEFRLYAFGLRTADGETVQSTLYMGILLALALVLPLTTIFLFKRRMLQFRLGVVEMILLLGAQIVMGIYYFLSYRLFSSFEFHAQSVKLPLVLPLIAMIFTYLAVRAIFRDELMIRSMDRIR
>NZ_AP019739.1|WP_019129839.1|1146390_1147350_-|glycosyltransferase-family-2-protein
MEKRLDISVVVPLYNEEESLPELTAWIDRVARENGLSYEIVFVDDGSTDGSWETLERLKEHYPALRAIGFARNYGKSAALYCGFAAAEGDVVFTMDADLQDSPDEIPDMRRMILEEGYDMVSGWKLKRHDPIGKRWPSKFFNWTARTVSGIKLHDFNCGLKAYRRKVVKSIEVYGEMHRYIPILAKEAGFRRIGEKVVCHRARKYGSSKFGMERMVKGYLDLITVSFLSHFGRSPMYFFGGLGTLMFLLGGCSTIWIIAAKLYKQAHGLPLRAVTEQPLFYLSMLLVILGVQFFLAGFLGELIDRNASDRNKYLIDKNI

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Crispr_ID: NZ_AP019739_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_8

1239643-1239752

Orphan

Consensus_repeat	Method
TCCGCTTGGATAGGCTGCGCCTCGGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_8

>merge|NZ_AP019739|8|1239643-1239752|CRISPRCasFinder
TCCGCTTGGATAGGCTGCGCCTCGGCAGATTCCAAATAAATTTGGATCTGCCCTCGGCTTGCACACTTTGCGGAGGACAAGCCTCCGCTTAGATAGGCTGCGCCTCGGCA

>NZ_AP019739|8|7|1239643-1239752|CRISPRCasFinder
TCCGCTTGGATAGGCTGCGCCTCGGCA	GATTCCAAATAAATTTGGATCTGCCCTCGGCTTGCACACTTTGCGGAGGACAAGCC
TCCGCTTAGATAGGCTGCGCCTCGGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141418595.1\|1245934_1246369_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235315
NZ_AP019739.1\|WP_141418587.1\|1235147_1236266_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|236515
NZ_AP019739.1\|WP_019129762.1\|1232401_1233964_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|130187
NZ_AP019739.1\|WP_141418588.1\|1237606_1238524_+\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
NZ_AP019739.1\|WP_141418596.1\|1246378_1247392_-\|DUF3575-domain-containing-protein	unknown	unknown	gnl\|CDD\|371897
NZ_AP019739.1\|WP_141418592.1\|1242580_1244302_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP019739.1\|WP_141418586.1\|1233982_1234393_-\|methylmalonyl-CoA-epimerase	unknown	unknown	gnl\|CDD\|213772
NZ_AP019739.1\|WP_141413164.1\|1237046_1237433_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_AP019739.1\|WP_019129760.1\|1234683_1235142_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239264
NZ_AP019739.1\|WP_019129764.1\|1231559_1232021_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|236449
NZ_AP019739.1\|WP_162502170.1\|1245762_1245930_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019129758.1\|1236583_1237039_+\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_AP019739.1\|WP_026074765.1\|1232032_1232371_-\|OadG-family-protein	unknown	unknown	gnl\|CDD\|377277
NZ_AP019739.1\|WP_081584283.1\|1246343_1246430_-\|DUF3575-domain-containing-protein	unknown	unknown	gnl\|CDD\|371897
NZ_AP019739.1\|WP_141418589.1\|1238570_1239401_+\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
NZ_AP019739.1\|WP_141418593.1\|1244625_1244955_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418591.1\|1241699_1242578_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275147
NZ_AP019739.1\|WP_141418594.1\|1245009_1245759_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418590.1\|1239855_1241253_+\|C1-family-peptidase	unknown	unknown	gnl\|CDD\|238328
NZ_AP019739.1\|WP_019129753.1\|1241289_1241703_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119396

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141418595.1\|1245934_1246369_-\|hypothetical-protein	gnl\|CDD\|235315	PRK04841, PRK04841, HTH-type transcriptional regulator MalT.	0.000280413
NZ_AP019739.1\|WP_141418587.1\|1235147_1236266_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|236515	PRK09435, PRK09435, methylmalonyl Co-A mutase-associated GTPase MeaB.	0
NZ_AP019739.1\|WP_019129762.1\|1232401_1233964_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|130187	TIGR01117, methylmalonyl-CoA_decarboxylase_alpha-subunit, methylmalonyl-CoA decarboxylase alpha subunit. This model describes methymalonyl-CoA decarboxylase aplha subunit in archaea and bacteria. Metylmalonyl-CoA decarboxylase Na+ pump is a representative of a class of Na+ transport decarboxylases that couples the energy derived by decarboxylation of carboxylic acid substrates to drive the extrusion of Na+ ion across the membrane. [Energy metabolism, ATP-proton motive force interconversion, Energy metabolism, Fermentation, Transport and binding proteins, Cations and iron carrying compounds].	0
NZ_AP019739.1\|WP_141418588.1\|1237606_1238524_+\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	2.52983e-129
NZ_AP019739.1\|WP_141418596.1\|1246378_1247392_-\|DUF3575-domain-containing-protein	gnl\|CDD\|371897	pfam12099, DUF3575, Protein of unknown function (DUF3575). This family of proteins are functionally uncharacterized. This family is only found in bacteria. Proteins in this family are typically between 187 to 236 amino acids in length.	1.16157e-08
NZ_AP019739.1\|WP_141418592.1\|1242580_1244302_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.63104e-78
NZ_AP019739.1\|WP_141418586.1\|1233982_1234393_-\|methylmalonyl-CoA-epimerase	gnl\|CDD\|213772	TIGR03081, Methylmalonyl-CoA_epimerase_mitochondrial, methylmalonyl-CoA epimerase. Members of this protein family are the enzyme methylmalonyl-CoA epimerase (EC 5.1.99.1), also called methylmalonyl-CoA racemase. This enzyme converts (2R)-methylmalonyl-CoA to (2S)-methylmalonyl-CoA, which is then a substrate for methylmalonyl-CoA mutase (TIGR00642). It is known in bacteria, archaea, and as a mitochondrial protein in animals. It is closely related to lactoylglutathione lyase (TIGR00068), which is also called glyoxylase I, and is also a homodimer.	4.16617e-58
NZ_AP019739.1\|WP_141413164.1\|1237046_1237433_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	3.16823e-73
NZ_AP019739.1\|WP_019129760.1\|1234683_1235142_+\|hypothetical-protein	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	6.82716e-08
NZ_AP019739.1\|WP_019129764.1\|1231559_1232021_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|236449	PRK09282, PRK09282, pyruvate carboxylase subunit B; Validated.	1.25969e-31
NZ_AP019739.1\|WP_019129758.1\|1236583_1237039_+\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	4.57121e-93
NZ_AP019739.1\|WP_026074765.1\|1232032_1232371_-\|OadG-family-protein	gnl\|CDD\|377277	pfam04277, OAD_gamma, Oxaloacetate decarboxylase, gamma chain.	2.39874e-09
NZ_AP019739.1\|WP_141418589.1\|1238570_1239401_+\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	6.54721e-91
NZ_AP019739.1\|WP_141418591.1\|1241699_1242578_-\|hypothetical-protein	gnl\|CDD\|275147	TIGR04352, hypothetical_protein_imdm_1353, HprK-related kinase A. A number of protein families resemble HPr kinase (see TIGR00679) but do not belong to that system. They include this family, which appears instead to be the marker for a different type of gene neighborhood, in which one of the conserved neighboring proteins resembles (but is distinct from) PqqD.	0.00855984
NZ_AP019739.1\|WP_081584283.1\|1246343_1246430_-\|DUF3575-domain-containing-protein	gnl\|CDD\|371897	pfam12099, DUF3575, Protein of unknown function (DUF3575). This family of proteins are functionally uncharacterized. This family is only found in bacteria. Proteins in this family are typically between 187 to 236 amino acids in length.	3.88369e-06
NZ_AP019739.1\|WP_141418590.1\|1239855_1241253_+\|C1-family-peptidase	gnl\|CDD\|238328	cd00585, Peptidase_C1B, Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is a cysteine peptidase that detoxifies bleomycin by hydrolysis of an amide group. It acts as a carboxypeptidase on its C-terminus to convert itself into an aminopeptidase and peptide ligase. BH is found in all tissues in mammals as well as in many other eukaryotes. Bleomycin, a glycopeptide derived from the fungus Streptomyces verticullus, is an effective anticancer drug due to its ability to induce DNA strand breaks. Human BH is the major cause of tumor cell resistance to bleomycin chemotherapy, and is also genetically linked to Alzheimer's disease. In addition to its peptidase activity, the yeast BH (Gal6) binds DNA and acts as a repressor in the Gal4 regulatory system. BH forms a hexameric ring barrel structure with the active sites imbedded in the central channel. The bacterial homolog of BH, called pepC, is a cysteine aminopeptidase possessing broad specificity. Although its crystal structure has not been solved, biochemical analysis shows that pepC also forms a hexamer. .	0
NZ_AP019739.1\|WP_019129753.1\|1241289_1241703_-\|hypothetical-protein	gnl\|CDD\|119396	cd06462, Peptidase_S24_S26, The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.	1.49664e-07

>NZ_AP019739.1|WP_141418589.1|1238570_1239401_+|elongation-factor-Ts
MEIKAADVMKLRKMTGAGMMDCKNALMEAEGDFARAQDIIREKGKLVVAKRAERNASEGVVVTRIVGTKAYMLCLACETDFVAQNAEFAASANAMIDIAVAADAVDKDTLMAVKNAEGRTVEEMVTEKSGQTGEKVEMAYYARIEAPYCHSYVHFNKKLGTILGFNKVVPEEVAHAVAMQATAMAPIAIDVADCPADVVAHERQITIEAMKQDPKNAGKPEAILEKIAEGKMRKFFEENTLLNQELVGEKKTIAQYIHEADKEATVVAYKRFALES
>NZ_AP019739.1|WP_141418588.1|1237606_1238524_+|30S-ribosomal-protein-S2
MSRTDFNTLLEAGAHFGHLKRKWNPKMAPYIFMEKNGIHIIDLHKTVIKIDEAAAAIKQIAKSGRRVLFVATKKQAKDIVAEKVAAIGMPYVTERWAGGMLTNFPTIRKAVKKMATIDKMTADGTFNNFSKREKLQIERQRAKLEKNLGSIADLTRLPAALFVVDVMKESNAVKEAKRLNIPVFAIVDTCCDPTDIDYVIPANDDASNSIAVILTAICAAVAEGTEERRLEKEKEAQEGIVSEEEGAPKKEGKPRIKKAVKATIDAEEAAVAEVVAATEQAATAAAEVVEAAAEKVEAAAEAQAE
>NZ_AP019739.1|WP_141413164.1|1237046_1237433_+|30S-ribosomal-protein-S9
MEIVNTVGRRKAAVARVFVKPGKGQITINRKALETYFPLDILQFQVKQPLLATNTVENYDIVINLDGGGIKGQAEAARLGIARALCEIDAEMRPVLKKAGFLTRDPREVERKKPGQPGARRKFQFSKR
>NZ_AP019739.1|WP_019129758.1|1236583_1237039_+|50S-ribosomal-protein-L13
MDSLSYKTISANAATVTKEWVVIDATNEVLGRLASQIAKILRGKNKPGYTPHVDCGDYVIVVNAEKVKLTGDKLTEKVYVRHTGYPGGQRFATAQDYLKKKPEFVIEEAVRGMLPKTRLGEAIFKNLKVYAGAEHPHAAQNPKAIKLNEIK
>NZ_AP019739.1|WP_141418587.1|1235147_1236266_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MSFTKIDHYEKEYVDHHHDSALSVTEGVADQPIVNPYFVRKKKHRLSTEEYVKGILEGNITTLSQAITLIESSNPDHYAQAQEIIERCLPHAGRSVRIGITGVPGAGKSTFIEAIGNMVTSLRHRLAVLAIDPSSERSGGSILGDKTRMESISANPDVFIRPSPSAGSLGGVARKTRETIVLCEAAGFDVIFIETVGVGQSETAVHSMVDLFMLLQISGAGDELQGIKRGIMEMADLMVITKADGENIHKAELAKTQFQSALQLFPLPESEWRPRVYTCSAVSGAGLEEVWKGVEEFLDHTQGNGFFRHNRNRQNKYWMYETIDETLKNSFYRDPRIEAEISVLEGQVLDDKISSFIAAKRLLDLYFGGKAE
>NZ_AP019739.1|WP_019129760.1|1234683_1235142_+|hypothetical-protein
MKRIFLALFLLSWTLGAASQNVALGEKTPDLKVKSWLDDRMPVPGRTFLLVFFHSTSRPAVESLAHLQELGRKFGDRVNVVVVVRESPEAVGGIVRPYAEGNLTVAFDDSGRSFAAYDVQYLPFGVLVSAKGRALWMGNPRQLTEAILDSNL
>NZ_AP019739.1|WP_141418586.1|1233982_1234393_-|methylmalonyl-CoA-epimerase
MEISHIEHLGIAVKSLDEAIPYWENVLGLKCYAIEEVPDQKVRTAFFKLGQTKIELLEPTSEDSTIAGFIEKRGIGIHHMALAVKNIEEQLADAEAKGIRLIDKTPRKGAEGMTIAFLHPKSTQGILTELCEDKNN
>NZ_AP019739.1|WP_019129762.1|1232401_1233964_-|acyl-CoA-carboxylase-subunit-beta
MSEIQNKINTLIENREKARMGGGQKRIDAQHGKGKYTARERIQMLLDEGSFEEFDMFVTHRCYDFGMDKSHTFGDGVVTGYGTIGGRLVYVFAQDFTVTAGSLSLSMSDKICKVMDMAMRNGAPCIGLNDSGGARIQEGINALAGYANIFQRNVMASGVIPQISAIFGPCAGGAVYSPALTDFIIMKKETSNMFLTGPKVVKTVTGEDVTQEQLGGAMMHTTKSGVAQFAVDTEEEGIEMIKKLLSYMPQNNMEDAPLAVCTDRIDRLEDSLNEIIPDNANKPYDMAEVIKAIVDNGEYLESAASYAKNVITCFARFNGQSVGIIANQPKFMAGVLDINASRKAARFVRFCDAFNIPLVTLVDVPGFLPGTTQEYGGVITHGAKLLFAYCEATVPKITVTLRKAYGGAYIVMSSKHIRGDINYAWPTAEIAVMGASGAVGVLHAKEVAAIENPEERAKFVAEKEQEYNDKFSNPYNAARYGYIDDVIEPRNTRFRIIRALQALSTKRLQNPPKKHSNIPL
>NZ_AP019739.1|WP_026074765.1|1232032_1232371_-|OadG-family-protein
MDWGWPEMLWTTLISICLVFGILVLLVWIMKLFGMIFVSRRKAAAAATQSGKPVEQGQLHEEEIAAIATALKIFNSDRHDRESDVLTIMSIKRAYSPWNSKIHGLTQMPDKK
>NZ_AP019739.1|WP_019129764.1|1231559_1232021_-|biotin/lipoyl-binding-protein
MKDYALKINGHNYDVRIDDVNESSTLAHVVVNGTAYEVEIAGAKGAATKRPQVAPAPREADSAKITPATAAPAPRIAPVAPSTGYTIKCPLPGTVLSINVKVGDTIATGQTLVILEAMKMENNIDADRAGVVKQIFVQQGATVMEGDNLILIE
>NZ_AP019739.1|WP_141418590.1|1239855_1241253_+|C1-family-peptidase
MKRIVLIGAFAVSSLLPLGAQNDGGISDGMLQRIRASYEDTPADRALRNAICNNDIRKLVVNQPNQGEIDTYFSHRVPSKGVTDQQQSGRCWLFSGLNVLRARMIARYGLGAFEFSQNYCFFWDQLEKANLFLQGVIDTRDAPREDRTVEWLFKNPLSDGGQFTGVADIVSKYGLVPKEAMPETYSSEHTAQMASLLKLKLREYGLSLREAARDGAEKAKLESRKTEMLGVIYRMLVLNLGEPPVRFTWTRRDAEGRPVDTREYTPRSFFETYVADDLTGNYVMLMNDPTRDYYECYEIDYDRHVYDGRNWTYVNLPVEEIKRMAVASIRDSTMMYFSCDVGKFLDSGRGLLDVDNFDYESLMGTTFGMDKRRRVESFASGSSHAMTLVAVDLDADGRPKKWMVENSWGPSSGYKGHLIMTDRWFDEYMFRLVVERKYVPQRVLDVLKQKPVRLPAWDPMFADEE
>NZ_AP019739.1|WP_019129753.1|1241289_1241703_-|hypothetical-protein
MKRTVPNRMLFAETRDQLLAGREVVVRVLGQSMLPFFRSGSRITLRPLREGDLRRGHVVLGETDNGHFVVHRILTVGDERVTLLGDGNTVGTETIPRERIYGIVDCGRLHLWLAERWMRLRPLRRYPLAILRRICRK
>NZ_AP019739.1|WP_141418591.1|1241699_1242578_-|hypothetical-protein
MDYLVAQDLIRSEHLDLVREGGLNGFKPFETTCGAATEPLIRLSPAEPLTLDDFAGYRELDRFDFDEAVADCHFGRYDGGRLFYMTAPGQRPVLFAKADGDPLVRSNVAADGRPDPSLLRFGLWMSFGIAHNPHSIAIHSSVIVHSGRAVLFLGESGTGKSTHTRLWREHIPGAQLLNDDSPIVRVVEGVPTVFGSPWSGKTPCYRNESYPIAAFVRLAQAPHNRIARLPVVRAIGALLPSCPPAFAYDAQLQDNICDTLSQLIARVPVYQLECLPDADAARLSFETTIADR
>NZ_AP019739.1|WP_141418592.1|1242580_1244302_-|ATP-binding-cassette-domain-containing-protein
MYPMKPPFLDIIPHRFRRRSLGVTLSVFTRALLNFAGLAVLIPVLVIILDTEGIRSNRWLAALYDFGGFTSDRTFILTVCACVVAVILFKSLANLALYKIERNFIYDLYRELSRRLYVDYRNRGLGFIKSSNSAVLARNVNVVCLTFVTGVLMPVAAMASEAVLFALLFGSLAIYNPLVALLTLAIFVPSVALYYYLVRQRLNRYGEEENRAQRRKSRTVIETFRGYADLEIAGAYPAMLSDFDRSMDEIIRVRQRNATIAALPPMFTEVGLAVGMAVLVAFCAGTDNTQMKLLFGIFAVAALRIMPSVRSIMGAWTSLRYNRYTIDVLRDARLYDTPAGIDTTQERMPFEREIRIEGLSFHFDDAPDRDILHDLSLTIRKGERIGIRGASGVGKTTLFNILLGFYRPTAGRITIDGRPLDETNLRKWQNTIGYVSQSVFIADSSFMQNVALGCAPDRIDRRRAAQALETAKLKEFIDTLPQGMETPIGECGCRLSGGQRQRLGIARALYKQADILFFDEATSALDNRTEERINRAIEELSKANRELTIVVVAHRESSLDYCDRIITLGEKTA
>NZ_AP019739.1|WP_141418593.1|1244625_1244955_-|hypothetical-protein
MYRLPQFDIGWQKYADLFRLERNDKDRERDAFDNIPPEIFASKALLAYGIRTDTFDLVPTVRNYEKLIDNVSHTSYHNNNNYYYNFDIAVLQTMQHRGALRATMISYFP
>NZ_AP019739.1|WP_141418594.1|1245009_1245759_-|hypothetical-protein
MGSSDITNVYAALDRTHTVVALERSRRGDEGFRTFFDEFADYAANKGYIPYLLLLNFHVDDGSRLPPIEAKERSYRLAHLAPLEVKDIRQALTLYDLLYCRKHGLDPLAAQNTARNLCYKDDYAGFRNESIPVLKQPGAPYGAVETEGGVALFRRGEQPADSAQRGPALQHIVRLHDAAFCWQMNIFHLSSEVKLEQLRHHDGYERAMFYLGKGMKQLSKFGTLTAAKTRWELLLSTDTPLGTGCYEEM
>NZ_AP019739.1|WP_162502170.1|1245762_1245930_-|hypothetical-protein
MTTNHLRRIFAAMLLLLALCGLGACTFHEVEEIEVIHAPEGDGTIVVPDWDDTKR
>NZ_AP019739.1|WP_141418595.1|1245934_1246369_-|hypothetical-protein
MRGFSRSAETSSWRPVRAVKLRCHLRRVGTVKDTIHTTEPDTAYLRGRQLLEKRKYTQALYVLHDYRDRNTAIALLSLGQDREALRILEALPATAISEYLRAIACSRLGRKAEGRRHFLEACRRNEHMEYRAALDPEIDELLKN
>NZ_AP019739.1|WP_081584283.1|1246343_1246430_-|DUF3575-domain-containing-protein
MGNRHRTYDGRAYGIGISYGYAWILSKR
>NZ_AP019739.1|WP_141418596.1|1246378_1247392_-|DUF3575-domain-containing-protein
MATEENVNPTEGQEQENDYRETLPVRNPDSGQVEAVSKLVTKDRREVHTVQPLAKNRPAFYPFRSSNAVAAFIRGFKSQKDNPIQFQFLKVPVLSVGKIVTSLGKLVSNPKSEEGWETYNKYVVNTAELEQVKYDKVEIPRAELQELGIDFDALPQRTQRSLMLGLPTRELFPATVQLSNHGTTTGLFNLSFYRDHNDELKFRLDTPLVQPEYEREEYASEITPDNKALLMCLAAIHHRTAAQFFGVRANALTALTGTVAVGAEAALTDNWTVETSAYWNPIRTKRITTQVGAYSSASDTGSTKISSGTFWCCTPPEPITASATVTALMTGGPTASA

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Crispr_ID: NZ_AP019739_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_9

1244307-1244442

Orphan

Consensus_repeat	Method
CGTGCAAGCCGAGCGCAGAACCAAATTTATTTGGGATTTGCCGAGGCGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_9

>merge|NZ_AP019739|9|1244307-1244442|CRISPRCasFinder
AGTGCAAGCCGAGCGCAGAACCAAATTTATTTGGGATTTGCCGAGGCGCCGCCTATCTAAGCGGAGGCTTGTCCTCCGCAAAGTCGTGCAAGCCGAGCGCAGAACCAAATTTATTTGGGATTTGCCGAGGCGCCGC

>NZ_AP019739|9|8|1244307-1244442|CRISPRCasFinder
AGTGCAAGCCGAGCGCAGAACCAAATTTATTTGGGATTTGCCGAGGCGCCGC	CTATCTAAGCGGAGGCTTGTCCTCCGCAAAGT
CGTGCAAGCCGAGCGCAGAACCAAATTTATTTGGGATTTGCCGAGGCGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141418595.1\|1245934_1246369_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235315
NZ_AP019739.1\|WP_141418598.1\|1250068_1250617_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418587.1\|1235147_1236266_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|236515
NZ_AP019739.1\|WP_019129753.1\|1241289_1241703_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119396
NZ_AP019739.1\|WP_141418596.1\|1246378_1247392_-\|DUF3575-domain-containing-protein	unknown	unknown	gnl\|CDD\|371897
NZ_AP019739.1\|WP_141418592.1\|1242580_1244302_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NZ_AP019739.1\|WP_081584283.1\|1246343_1246430_-\|DUF3575-domain-containing-protein	unknown	unknown	gnl\|CDD\|371897
NZ_AP019739.1\|WP_141413164.1\|1237046_1237433_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_AP019739.1\|WP_141418599.1\|1250619_1250967_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019129760.1\|1234683_1235142_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239264
NZ_AP019739.1\|WP_162502170.1\|1245762_1245930_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_162502171.1\|1248636_1249761_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274730
NZ_AP019739.1\|WP_019129758.1\|1236583_1237039_+\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_AP019739.1\|WP_141418589.1\|1238570_1239401_+\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
NZ_AP019739.1\|WP_141413172.1\|1247977_1248637_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418593.1\|1244625_1244955_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418591.1\|1241699_1242578_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275147
NZ_AP019739.1\|WP_141418594.1\|1245009_1245759_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418590.1\|1239855_1241253_+\|C1-family-peptidase	unknown	unknown	gnl\|CDD\|238328
NZ_AP019739.1\|WP_141418588.1\|1237606_1238524_+\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141418595.1\|1245934_1246369_-\|hypothetical-protein	gnl\|CDD\|235315	PRK04841, PRK04841, HTH-type transcriptional regulator MalT.	0.000280413
NZ_AP019739.1\|WP_141418587.1\|1235147_1236266_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|236515	PRK09435, PRK09435, methylmalonyl Co-A mutase-associated GTPase MeaB.	0
NZ_AP019739.1\|WP_019129753.1\|1241289_1241703_-\|hypothetical-protein	gnl\|CDD\|119396	cd06462, Peptidase_S24_S26, The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.	1.49664e-07
NZ_AP019739.1\|WP_141418596.1\|1246378_1247392_-\|DUF3575-domain-containing-protein	gnl\|CDD\|371897	pfam12099, DUF3575, Protein of unknown function (DUF3575). This family of proteins are functionally uncharacterized. This family is only found in bacteria. Proteins in this family are typically between 187 to 236 amino acids in length.	1.16157e-08
NZ_AP019739.1\|WP_141418592.1\|1242580_1244302_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.63104e-78
NZ_AP019739.1\|WP_141413164.1\|1237046_1237433_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	3.16823e-73
NZ_AP019739.1\|WP_019129760.1\|1234683_1235142_+\|hypothetical-protein	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	6.82716e-08
NZ_AP019739.1\|WP_019129758.1\|1236583_1237039_+\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	4.57121e-93
NZ_AP019739.1\|WP_141418589.1\|1238570_1239401_+\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	6.54721e-91
NZ_AP019739.1\|WP_162502171.1\|1248636_1249761_-\|hypothetical-protein	gnl\|CDD\|274730	TIGR03696, tRNA_nuclease_WapA, RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.	6.63703e-11
NZ_AP019739.1\|WP_141418591.1\|1241699_1242578_-\|hypothetical-protein	gnl\|CDD\|275147	TIGR04352, hypothetical_protein_imdm_1353, HprK-related kinase A. A number of protein families resemble HPr kinase (see TIGR00679) but do not belong to that system. They include this family, which appears instead to be the marker for a different type of gene neighborhood, in which one of the conserved neighboring proteins resembles (but is distinct from) PqqD.	0.00855984
NZ_AP019739.1\|WP_081584283.1\|1246343_1246430_-\|DUF3575-domain-containing-protein	gnl\|CDD\|371897	pfam12099, DUF3575, Protein of unknown function (DUF3575). This family of proteins are functionally uncharacterized. This family is only found in bacteria. Proteins in this family are typically between 187 to 236 amino acids in length.	3.88369e-06
NZ_AP019739.1\|WP_141418590.1\|1239855_1241253_+\|C1-family-peptidase	gnl\|CDD\|238328	cd00585, Peptidase_C1B, Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is a cysteine peptidase that detoxifies bleomycin by hydrolysis of an amide group. It acts as a carboxypeptidase on its C-terminus to convert itself into an aminopeptidase and peptide ligase. BH is found in all tissues in mammals as well as in many other eukaryotes. Bleomycin, a glycopeptide derived from the fungus Streptomyces verticullus, is an effective anticancer drug due to its ability to induce DNA strand breaks. Human BH is the major cause of tumor cell resistance to bleomycin chemotherapy, and is also genetically linked to Alzheimer's disease. In addition to its peptidase activity, the yeast BH (Gal6) binds DNA and acts as a repressor in the Gal4 regulatory system. BH forms a hexameric ring barrel structure with the active sites imbedded in the central channel. The bacterial homolog of BH, called pepC, is a cysteine aminopeptidase possessing broad specificity. Although its crystal structure has not been solved, biochemical analysis shows that pepC also forms a hexamer. .	0
NZ_AP019739.1\|WP_141418588.1\|1237606_1238524_+\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	2.52983e-129

>NZ_AP019739.1|WP_141418592.1|1242580_1244302_-|ATP-binding-cassette-domain-containing-protein
MYPMKPPFLDIIPHRFRRRSLGVTLSVFTRALLNFAGLAVLIPVLVIILDTEGIRSNRWLAALYDFGGFTSDRTFILTVCACVVAVILFKSLANLALYKIERNFIYDLYRELSRRLYVDYRNRGLGFIKSSNSAVLARNVNVVCLTFVTGVLMPVAAMASEAVLFALLFGSLAIYNPLVALLTLAIFVPSVALYYYLVRQRLNRYGEEENRAQRRKSRTVIETFRGYADLEIAGAYPAMLSDFDRSMDEIIRVRQRNATIAALPPMFTEVGLAVGMAVLVAFCAGTDNTQMKLLFGIFAVAALRIMPSVRSIMGAWTSLRYNRYTIDVLRDARLYDTPAGIDTTQERMPFEREIRIEGLSFHFDDAPDRDILHDLSLTIRKGERIGIRGASGVGKTTLFNILLGFYRPTAGRITIDGRPLDETNLRKWQNTIGYVSQSVFIADSSFMQNVALGCAPDRIDRRRAAQALETAKLKEFIDTLPQGMETPIGECGCRLSGGQRQRLGIARALYKQADILFFDEATSALDNRTEERINRAIEELSKANRELTIVVVAHRESSLDYCDRIITLGEKTA
>NZ_AP019739.1|WP_141418591.1|1241699_1242578_-|hypothetical-protein
MDYLVAQDLIRSEHLDLVREGGLNGFKPFETTCGAATEPLIRLSPAEPLTLDDFAGYRELDRFDFDEAVADCHFGRYDGGRLFYMTAPGQRPVLFAKADGDPLVRSNVAADGRPDPSLLRFGLWMSFGIAHNPHSIAIHSSVIVHSGRAVLFLGESGTGKSTHTRLWREHIPGAQLLNDDSPIVRVVEGVPTVFGSPWSGKTPCYRNESYPIAAFVRLAQAPHNRIARLPVVRAIGALLPSCPPAFAYDAQLQDNICDTLSQLIARVPVYQLECLPDADAARLSFETTIADR
>NZ_AP019739.1|WP_019129753.1|1241289_1241703_-|hypothetical-protein
MKRTVPNRMLFAETRDQLLAGREVVVRVLGQSMLPFFRSGSRITLRPLREGDLRRGHVVLGETDNGHFVVHRILTVGDERVTLLGDGNTVGTETIPRERIYGIVDCGRLHLWLAERWMRLRPLRRYPLAILRRICRK
>NZ_AP019739.1|WP_141418590.1|1239855_1241253_+|C1-family-peptidase
MKRIVLIGAFAVSSLLPLGAQNDGGISDGMLQRIRASYEDTPADRALRNAICNNDIRKLVVNQPNQGEIDTYFSHRVPSKGVTDQQQSGRCWLFSGLNVLRARMIARYGLGAFEFSQNYCFFWDQLEKANLFLQGVIDTRDAPREDRTVEWLFKNPLSDGGQFTGVADIVSKYGLVPKEAMPETYSSEHTAQMASLLKLKLREYGLSLREAARDGAEKAKLESRKTEMLGVIYRMLVLNLGEPPVRFTWTRRDAEGRPVDTREYTPRSFFETYVADDLTGNYVMLMNDPTRDYYECYEIDYDRHVYDGRNWTYVNLPVEEIKRMAVASIRDSTMMYFSCDVGKFLDSGRGLLDVDNFDYESLMGTTFGMDKRRRVESFASGSSHAMTLVAVDLDADGRPKKWMVENSWGPSSGYKGHLIMTDRWFDEYMFRLVVERKYVPQRVLDVLKQKPVRLPAWDPMFADEE
>NZ_AP019739.1|WP_141418589.1|1238570_1239401_+|elongation-factor-Ts
MEIKAADVMKLRKMTGAGMMDCKNALMEAEGDFARAQDIIREKGKLVVAKRAERNASEGVVVTRIVGTKAYMLCLACETDFVAQNAEFAASANAMIDIAVAADAVDKDTLMAVKNAEGRTVEEMVTEKSGQTGEKVEMAYYARIEAPYCHSYVHFNKKLGTILGFNKVVPEEVAHAVAMQATAMAPIAIDVADCPADVVAHERQITIEAMKQDPKNAGKPEAILEKIAEGKMRKFFEENTLLNQELVGEKKTIAQYIHEADKEATVVAYKRFALES
>NZ_AP019739.1|WP_141418588.1|1237606_1238524_+|30S-ribosomal-protein-S2
MSRTDFNTLLEAGAHFGHLKRKWNPKMAPYIFMEKNGIHIIDLHKTVIKIDEAAAAIKQIAKSGRRVLFVATKKQAKDIVAEKVAAIGMPYVTERWAGGMLTNFPTIRKAVKKMATIDKMTADGTFNNFSKREKLQIERQRAKLEKNLGSIADLTRLPAALFVVDVMKESNAVKEAKRLNIPVFAIVDTCCDPTDIDYVIPANDDASNSIAVILTAICAAVAEGTEERRLEKEKEAQEGIVSEEEGAPKKEGKPRIKKAVKATIDAEEAAVAEVVAATEQAATAAAEVVEAAAEKVEAAAEAQAE
>NZ_AP019739.1|WP_141413164.1|1237046_1237433_+|30S-ribosomal-protein-S9
MEIVNTVGRRKAAVARVFVKPGKGQITINRKALETYFPLDILQFQVKQPLLATNTVENYDIVINLDGGGIKGQAEAARLGIARALCEIDAEMRPVLKKAGFLTRDPREVERKKPGQPGARRKFQFSKR
>NZ_AP019739.1|WP_019129758.1|1236583_1237039_+|50S-ribosomal-protein-L13
MDSLSYKTISANAATVTKEWVVIDATNEVLGRLASQIAKILRGKNKPGYTPHVDCGDYVIVVNAEKVKLTGDKLTEKVYVRHTGYPGGQRFATAQDYLKKKPEFVIEEAVRGMLPKTRLGEAIFKNLKVYAGAEHPHAAQNPKAIKLNEIK
>NZ_AP019739.1|WP_141418587.1|1235147_1236266_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MSFTKIDHYEKEYVDHHHDSALSVTEGVADQPIVNPYFVRKKKHRLSTEEYVKGILEGNITTLSQAITLIESSNPDHYAQAQEIIERCLPHAGRSVRIGITGVPGAGKSTFIEAIGNMVTSLRHRLAVLAIDPSSERSGGSILGDKTRMESISANPDVFIRPSPSAGSLGGVARKTRETIVLCEAAGFDVIFIETVGVGQSETAVHSMVDLFMLLQISGAGDELQGIKRGIMEMADLMVITKADGENIHKAELAKTQFQSALQLFPLPESEWRPRVYTCSAVSGAGLEEVWKGVEEFLDHTQGNGFFRHNRNRQNKYWMYETIDETLKNSFYRDPRIEAEISVLEGQVLDDKISSFIAAKRLLDLYFGGKAE
>NZ_AP019739.1|WP_019129760.1|1234683_1235142_+|hypothetical-protein
MKRIFLALFLLSWTLGAASQNVALGEKTPDLKVKSWLDDRMPVPGRTFLLVFFHSTSRPAVESLAHLQELGRKFGDRVNVVVVVRESPEAVGGIVRPYAEGNLTVAFDDSGRSFAAYDVQYLPFGVLVSAKGRALWMGNPRQLTEAILDSNL
>NZ_AP019739.1|WP_141418593.1|1244625_1244955_-|hypothetical-protein
MYRLPQFDIGWQKYADLFRLERNDKDRERDAFDNIPPEIFASKALLAYGIRTDTFDLVPTVRNYEKLIDNVSHTSYHNNNNYYYNFDIAVLQTMQHRGALRATMISYFP
>NZ_AP019739.1|WP_141418594.1|1245009_1245759_-|hypothetical-protein
MGSSDITNVYAALDRTHTVVALERSRRGDEGFRTFFDEFADYAANKGYIPYLLLLNFHVDDGSRLPPIEAKERSYRLAHLAPLEVKDIRQALTLYDLLYCRKHGLDPLAAQNTARNLCYKDDYAGFRNESIPVLKQPGAPYGAVETEGGVALFRRGEQPADSAQRGPALQHIVRLHDAAFCWQMNIFHLSSEVKLEQLRHHDGYERAMFYLGKGMKQLSKFGTLTAAKTRWELLLSTDTPLGTGCYEEM
>NZ_AP019739.1|WP_162502170.1|1245762_1245930_-|hypothetical-protein
MTTNHLRRIFAAMLLLLALCGLGACTFHEVEEIEVIHAPEGDGTIVVPDWDDTKR
>NZ_AP019739.1|WP_141418595.1|1245934_1246369_-|hypothetical-protein
MRGFSRSAETSSWRPVRAVKLRCHLRRVGTVKDTIHTTEPDTAYLRGRQLLEKRKYTQALYVLHDYRDRNTAIALLSLGQDREALRILEALPATAISEYLRAIACSRLGRKAEGRRHFLEACRRNEHMEYRAALDPEIDELLKN
>NZ_AP019739.1|WP_081584283.1|1246343_1246430_-|DUF3575-domain-containing-protein
MGNRHRTYDGRAYGIGISYGYAWILSKR
>NZ_AP019739.1|WP_141418596.1|1246378_1247392_-|DUF3575-domain-containing-protein
MATEENVNPTEGQEQENDYRETLPVRNPDSGQVEAVSKLVTKDRREVHTVQPLAKNRPAFYPFRSSNAVAAFIRGFKSQKDNPIQFQFLKVPVLSVGKIVTSLGKLVSNPKSEEGWETYNKYVVNTAELEQVKYDKVEIPRAELQELGIDFDALPQRTQRSLMLGLPTRELFPATVQLSNHGTTTGLFNLSFYRDHNDELKFRLDTPLVQPEYEREEYASEITPDNKALLMCLAAIHHRTAAQFFGVRANALTALTGTVAVGAEAALTDNWTVETSAYWNPIRTKRITTQVGAYSSASDTGSTKISSGTFWCCTPPEPITASATVTALMTGGPTASA
>NZ_AP019739.1|WP_141413172.1|1247977_1248637_-|hypothetical-protein
MYKVFFQIVAILLPLTLSGCLNKEQYKQKQLDKIQTCVNQFRATHRVDYLDSALLVMNQVVEQFPEYRGVASYKIAEIYYLKKDYEQALAELENAEEGVYSKIKPIWKNKIKVKIAEKAGDSLEIRSLYKQLYDDYLSGYREIDSIVKVVLKKQNDNEIYFSEINLLHVEMYHYRRLLTDTETILASIDSLQAATQGNERYFERLKNLFIDDNYEIFLE
>NZ_AP019739.1|WP_162502171.1|1248636_1249761_-|hypothetical-protein
MNADDCGFAYRGSFTYRADAGGNRVFESTPFGGGRIVATAGNDTEIRYFLTDHLGSVRVVATDKDNVLERNDYQPFGKRWNTASLPVSDNRDRFNGKEDQAFAGLPFSDYDARCYNKLNGRWLSQDPLADEYINHSQYCFCGNNPISMIDRDGRDWIRNLETDEYEWNDNVKSREDTPAGYEYIGAFDSDILYDIGVSTNLYYEASSWSPYLSFGTEVPQHNLSGRGGLLSLLLPALEGAVGLIGEGYIRFQVSIGYDSKKVSETNSLGKVFNGVIIHAIINQMITPRTAYNGDIEVYMTNGEMYSIALKEPPYPILTNPFTYSMGIDAILSSESVSHNNPISKIVLNASLNNAQKNIMQGGNMGIKFNFNSKR
>NZ_AP019739.1|WP_141418598.1|1250068_1250617_-|hypothetical-protein
MKNFCENVQAVFHIADKYTKTHLPFQIFVNREFKFLITSGGAFVDNKNEYIKFSSVLNTIGEEYICLLEHIDNQYASDSPFKGVIKTCEGFEAFRRLETTFDPHFGLILSNFYIFGANPNWGIYLCEYPAIKLIGCIDRYIPAFKDAFNIRGTGFEEVEPLLEQEFGQNRNFQNKLIENYHL
>NZ_AP019739.1|WP_141418599.1|1250619_1250967_-|hypothetical-protein
MQSRGVYQNDLGLQGILQNPQKKQIYKNADDLISAAKELKRLKGGVRQGRVIGNIDEIFQSISQGGQRIGKNSFRLPDGTIITKYSSSTTGVPTIHINKQGQLFKIRVETGINIE

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Crispr_ID: NZ_AP019739_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_10

1504550-1504673

Orphan

Consensus_repeat	Method
GAGCGGAGGCTCGTCCTCCGCAAAGTGTGCAAGCCGAGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_10

>merge|NZ_AP019739|10|1504550-1504673|CRISPRCasFinder
GAGCGGAGGCTCGTCCTCCGCAAAGTGTGCAAGCCGAGTGCAAAAGCAAACTTGTTCGCGGTTTTGCCGAGGCGCAGCCTATCCGAGCGGAGGCTCGTCCTCCGCAAAGTGTGCAAGCCGAGTG

>NZ_AP019739|10|9|1504550-1504673|CRISPRCasFinder
GAGCGGAGGCTCGTCCTCCGCAAAGTGTGCAAGCCGAGTG	CAAAAGCAAACTTGTTCGCGGTTTTGCCGAGGCGCAGCCTATCC
GAGCGGAGGCTCGTCCTCCGCAAAGTGTGCAAGCCGAGTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141418728.1\|1513666_1516687_-\|outer-membrane-beta-barrel-protein	unknown	unknown	gnl\|CDD\|379720
NZ_AP019739.1\|WP_141413320.1\|1498249_1499590_-\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234586
NZ_AP019739.1\|WP_141418722.1\|1500172_1501846_-\|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl\|CDD\|236992
NZ_AP019739.1\|WP_141418724.1\|1506377_1507541_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_AP019739.1\|WP_141413318.1\|1496100_1496430_-\|DUF3276-family-protein	unknown	unknown	gnl\|CDD\|378691
NZ_AP019739.1\|WP_141418729.1\|1518104_1519481_-\|termination-factor-Rho	unknown	unknown	gnl\|CDD\|225814
NZ_AP019739.1\|WP_141418725.1\|1507537_1508623_+\|pyrimidine-reductase	unknown	unknown	gnl\|CDD\|224896
NZ_AP019739.1\|WP_141418726.1\|1508726_1510169_+\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_AP019739.1\|WP_141413321.1\|1499592_1500120_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418721.1\|1494000_1494741_-\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|223247
NZ_AP019739.1\|WP_019129491.1\|1511184_1512363_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_AP019739.1\|WP_141413319.1\|1496573_1498163_-\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|223864
NZ_AP019739.1\|WP_141418723.1\|1504850_1506197_-\|porin	unknown	unknown	unknown
NZ_AP019739.1\|WP_141413329.1\|1517340_1518108_-\|response-regulator	unknown	unknown	gnl\|CDD\|225818
NZ_AP019739.1\|WP_026074714.1\|1504156_1504474_-\|DUF4491-family-protein	unknown	unknown	gnl\|CDD\|379717
NZ_AP019739.1\|WP_019129490.1\|1512365_1513577_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NZ_AP019739.1\|WP_141413317.1\|1494737_1495676_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|377196
NZ_AP019739.1\|WP_141419649.1\|1503059_1504076_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|378215
NZ_AP019739.1\|WP_019129500.1\|1502428_1503004_+\|rubrerythrin-family-protein	unknown	unknown	gnl\|CDD\|153100
NZ_AP019739.1\|WP_141418727.1\|1510185_1511172_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|235136

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141418728.1\|1513666_1516687_-\|outer-membrane-beta-barrel-protein	gnl\|CDD\|379720	pfam14905, OMP_b-brl_3, Outer membrane protein beta-barrel family. This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	2.78662e-13
NZ_AP019739.1\|WP_141413320.1\|1498249_1499590_-\|histidine--tRNA-ligase	gnl\|CDD\|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	2.02889e-148
NZ_AP019739.1\|WP_141418722.1\|1500172_1501846_-\|energy-dependent-translational-throttle-protein-EttA	gnl\|CDD\|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
NZ_AP019739.1\|WP_141413317.1\|1494737_1495676_-\|DUF368-domain-containing-protein	gnl\|CDD\|377196	pfam04018, DUF368, Domain of unknown function (DUF368). Predicted transmembrane domain of unknown function. Family members have between 6 and 9 predicted transmembrane segments.	2.01504e-115
NZ_AP019739.1\|WP_141413318.1\|1496100_1496430_-\|DUF3276-family-protein	gnl\|CDD\|378691	pfam11680, DUF3276, Protein of unknown function (DUF3276). This bacterial family of proteins has no known function.	6.1842e-33
NZ_AP019739.1\|WP_141418729.1\|1518104_1519481_-\|termination-factor-Rho	gnl\|CDD\|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.71484e-26
NZ_AP019739.1\|WP_141418725.1\|1507537_1508623_+\|pyrimidine-reductase	gnl\|CDD\|224896	COG1985, RibD, Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism].	6.64006e-31
NZ_AP019739.1\|WP_141418726.1\|1508726_1510169_+\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	3.39588e-30
NZ_AP019739.1\|WP_141418721.1\|1494000_1494741_-\|shikimate-dehydrogenase	gnl\|CDD\|223247	COG0169, AroE, Shikimate 5-dehydrogenase [Amino acid transport and metabolism].	2.20745e-64
NZ_AP019739.1\|WP_019129491.1\|1511184_1512363_+\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	9.1504e-37
NZ_AP019739.1\|WP_141413319.1\|1496573_1498163_-\|PDZ-domain-containing-protein	gnl\|CDD\|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	1.53981e-93
NZ_AP019739.1\|WP_141413329.1\|1517340_1518108_-\|response-regulator	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	2.32407e-28
NZ_AP019739.1\|WP_026074714.1\|1504156_1504474_-\|DUF4491-family-protein	gnl\|CDD\|379717	pfam14898, DUF4491, Domain of unknown function (DUF4491). This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 107 amino acids in length. There is a conserved EYY sequence motif.	5.822e-46
NZ_AP019739.1\|WP_019129490.1\|1512365_1513577_+\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	2.05352e-33
NZ_AP019739.1\|WP_141418724.1\|1506377_1507541_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.03609e-48
NZ_AP019739.1\|WP_141419649.1\|1503059_1504076_-\|CapA-family-protein	gnl\|CDD\|378215	pfam09587, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	3.97593e-75
NZ_AP019739.1\|WP_019129500.1\|1502428_1503004_+\|rubrerythrin-family-protein	gnl\|CDD\|153100	cd01041, Rubrerythrin, Rubrerythrin, ferritin-like diiron-binding domain. Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.	2.49616e-64
NZ_AP019739.1\|WP_141418727.1\|1510185_1511172_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|235136	PRK03598, PRK03598, putative efflux pump membrane fusion protein; Provisional.	1.02102e-26

>NZ_AP019739.1|WP_026074714.1|1504156_1504474_-|DUF4491-family-protein
MEFLETYHLVGIVVGAATFLIIGVFHPFVIKGEYYFGVRCWWAFAVSGVAALAASLWVENLILSILLAVWGASSLWGIGELFEQRERVAKGWFPKREKKNRRGGR
>NZ_AP019739.1|WP_141419649.1|1503059_1504076_-|CapA-family-protein
MQRVVPATVPPDERIFRARLLFAGDVMAHLPQLTAARRSDGTHDFFGQFRLVKPRFDAADLVVVNLETTLSAAAPHTGYPCFRTPSSLARALRRAGVDVAVTANNHCCDGGARGIGATLAALDDAGLRHTGTFVDSLRHGADHPLRLAANGIRFALFNYTYGTNGLPVPTGTTVNRIDTTVIARDLAAVDRGAVDCVIAFVHWGNEYERRPDSEQRMLAGFLRRHGADLVVGSHPHVVQPFEQDSTGAVFYSLGNFVSNQRRRYCDGGLLAEVEVVKRIAAGVPTMHYAAQAVPVWVALPDYRILPPEVADTLAMPPHARAAYDRFMQDTRRLLDERE
>NZ_AP019739.1|WP_019129500.1|1502428_1503004_+|rubrerythrin-family-protein
MKSIKGTKTEQNLLTAFAGESQARNRYTYFASVAKKEGYEQIAGIFLETADQEKEHAKKFFKYLEGGCLSITASFPAGVIGTTEENLKAAAMGENEEWTEMYPEFARIADEEGFPEIAATFRMVIVAEHEHEDRYLKLLSRLTDGNFFIRDHEIWWQCRNCGYICKGTEAPKICPACKHPQAYFEPKRENY
>NZ_AP019739.1|WP_141418722.1|1500172_1501846_-|energy-dependent-translational-throttle-protein-EttA
MADEKIIFSMVGVSKTFTNQKKVLNNIYLSFFYGAKIGIIGLNGSGKSTLMKIIAGLDKNFQGEVVFSPGYTVGYLEQEPQLDDSKTVREVVEEGCAATVALLKEYEQINQQLCEPMDDDTMARLVERQGELYEQIDHAGGWELDNVLERAMDALRCPDPDQSVKVLSGGERRRVALCRLLLQQPDVLLLDEPTNHLDAESIDWLEQHLQQYKGTVIAVTHDRYFLDNVAGWILELDRGEGIPWKGNYSGWLEQKSKRLEMEEKQASKRRKTLERELEWVRMSPAGRHAKSKARLSAYDKMLNEDAKQQEEKLEIYIPNGPRLGDVVIEAHDVKKAFGDRVLYENLNFTLPPAGIVGVIGPNGTGKTTLFRMIMGLEQPTAGTFTVGQTVKLSYVDQQHKSIDPEKTVYEVISQNSEWIQLGNRQVPARAYVARFNFTGADQEKKCGVLSGGERNRLHLALALKEGGNVLLLDEPTNDIDVNTLRALEEGLENFAGCAVVISHDRWFLDRIATHILSFEGDSKVVFYQGSYSEFEEWKRAQGGDATPHRVKYKKLME
>NZ_AP019739.1|WP_141413321.1|1499592_1500120_-|hypothetical-protein
MFAFLSCARENPCIDAFCWDVQTAGMAQEESDIKGETDLDGFLAEIERFPWYDQAVLAERNPTLSPTVSVTDLKTDRSVFISVGLAGSRKVSYWVGYIYPVQKRFLGIDRLFRRVEMYETERMDRIIPIVKAFFGRDDQELRRRLAPLSPYLRVKESGGWSAYMDKKQQIVKQIK
>NZ_AP019739.1|WP_141413320.1|1498249_1499590_-|histidine--tRNA-ligase
MQKPSIPKGTRDFSPAEMMRRNYIFDSIRQVFRTFGFAPLETPAMENLSTLLGKYGDEGDKLLFKILNSGDYAAGLAPDELRQASKICEKGLRYDLTVPFARYVVQHQGEIVLPFKRYQIQPVWRADRPQKGRYREFYQCDVDVVGSRSLLNEVELVEIVERVFRKLGIAVTLRMNNRKILYGIAETIGHADKMIDITVAIDKLEKIGIDNVKAELRERGIDDAAIDRLQPILELRGDNRRKLSALRDVLSGSETGLKGVEELETVFGYVERLGIALAVELDLSLARGLNYYTGAIFEVKANDYAIGSICGGGRYDDLTGIFGMPDTSGVGISFGADRIYDVMVGLELFPEEVNFSTKVLFVNLGADEEAASLGLLRALRDAGVAAEIYPEKGKMKKQMEYANRRSIPYVAIVGSDELARQTVTLKDMRTGEQRQVPFAELAASLQ
>NZ_AP019739.1|WP_141413319.1|1496573_1498163_-|PDZ-domain-containing-protein
MKRLITLIVGVLCTAPWSVRAQFDDAAAAQLQKLVQAYRYVDAAYVDSLDTAPLVEEAIRGMLMRLDPHSAYLSEEEMKGVDESFDGSFGGIGIEFNVLNDTVVIVNTIAGGPSAQVGLLPGDRIVGIDGQRAVGLSRAEVPKRLRGPSGTQVRLEVSRHAVKEPLAFTVTRGDIPLHTVDAAYKVDAETGYIKVNRFGRTTMQEFVEAFKGMKGVRSLILDLRGNGGGLLDQAVAMANFFLPRGSRIVSTEGRAVPPRAYTAPVDGAFLRGPVVVLIDENSASASEIVAGALQDWDRAVVVGRPSFGKGLVQRQFRLGDGSAIRVTVARYHTPSGRVIQRPYEKGHREEYYAAHRERLTGVQADSVAAETPQFETLRTHRPVYGGGGIRPDVRVEADTVGQTGYWLALMRHGVVNELVLRYLDRERPQLTARYPDFERFDAGFAVSPAMMSELAEMAAAQGIEPAGDEAAQSDGLLKLQIKALVAERLFPREGFYRVMNAADGSMFRRAVELLGAWSEQGKHILSKRK
>NZ_AP019739.1|WP_141413318.1|1496100_1496430_-|DUF3276-family-protein
MFSRTDIPRKESEEVGEHILTKAVKAGRRTYFFDVRATRGNDYYLTITESRKTTVADGSVVFDRHKIFLYKEDFARFDRTLREVLDFIAACQRADEASARQKTEVPVSE
>NZ_AP019739.1|WP_141413317.1|1494737_1495676_-|DUF368-domain-containing-protein
MTNYLLLALKGCAMGMADVIPGVSGGTIAFISGIYTELIESIKKLGGPSLRLLAALRLREFWREINGNFLAAVFAGLLVAVFSLARAMTYLLEHHPIEIWAFFFGLIVASALLVARDVTRWNAASVVSLLCGIAVAWWITVASPSQTPETWWFILLSGAIAICAMILPGISGAFILLLMGKYQFILNAVSSFDIGILALFATGAVAGLVSFSHVLSWLLRRYHDVTISLLMGFMVGSLNKVWPWKETLESYFDSHGAAHPLVERNVLPATFTELTGTEAQVGWAVALCACGFLLIWGIEYVGNRIAAKKGEA
>NZ_AP019739.1|WP_141418721.1|1494000_1494741_-|shikimate-dehydrogenase
MKRYGLIGRPLGHSFSAGYFAAKFRREGITGCDYALYELPSIEALPELLGTQPELQGFNVTIPYKQRIFDYLDDVSEEAARIGAVNCVRRDGGRLTGFNTDIEGVRLSLRLLLGDDLPEAALVLGTGGASQAVQYALAEAGIPYAVVSRDPARGNFLYDDLRPEVVAGHRLIVNATPVGTFPHVDEAPLLPYEALTAAHYLFDLVYNPERTQFLLRGERQGARTLNGLPMLEAQAEASWRIWNGVI
>NZ_AP019739.1|WP_141418723.1|1504850_1506197_-|porin
MKTVRLFIVALFLTVAASAQPNASSARDGGSPTVYMISVQETDTLIPCEWRARAARNRMAMMDAVDDYNQTHRTGFQQPGRPQFLFAHKQNKYSLALGGFIALRTSYDFDGTPSATDFIPSSIPVPGDYASRQRLSMDASTSRIYLKGIANTRALGRVVVYVSTDFRGGAQGSYTPRLREAYVSFKGFTFGRDVTTFCDLDAGPTTIDFQGPNAYNFTFATMIRYEVPFANDHLKFGLAAELPSVSGTFGETFDPIPQRVPDFPVYFQYAWGAKRDSHFRVTGVVRDLYLHNAATGNNTSLLGWGVQASTCINLARVLTIYGNGVYGEGITNYIQDLSGLGYDFTPDPQDPAKVQTMPMWGWYGAARINILPQRLFISGGYSEAHIQQKHGYFSGDQYRNGQYIFGNIFYNFTSRCSIAAEYLYGSRENRDGMKNHANRVSMQVQYNF
>NZ_AP019739.1|WP_141418724.1|1506377_1507541_+|metallophosphoesterase
MMWMPLFLILLPLAADGWYFRRHRKAYRYRNLLLTLVAAGDLLPLAGIVLFWLVKDNTGGVVTAAMWIFFAYLLLTLPRMAYYAVRAFGKGRATRILAPIAALGMAGVLIHGAVSGRSTLAVHRVTLRSDRLPEAFDGLRIAQFTDLHIGTLVDPDREMRALVDSLNALRPDLVIFCGDLVNIRYTELDSTAMRLLGGIRSRYGTFSITGNHDTGNYVRDTLSLPPATNIAALVERQRAMGWRVLDNETVYLRRGDDSIALSGISYDRSLARQRHDRTLPGYDFSTTYRDVPQELYNITAAHIPQLWEQILDAGYGDLTLSGHVHSMQCKIRLFGRAFSPAQLMYRHWSGPYEKQGRTLYVNDGIGYVGFPMRIGANPEITLFELRR
>NZ_AP019739.1|WP_141418725.1|1507537_1508623_+|pyrimidine-reductase
MNVYASVALSGDGYMDDRSPRRLILSTPSDWREVMRLRAWADAILVGAETVRRDDPSLTVRDEALRRERLAANRPADPAKVTLSRSLRLAPASNFFTAGSGARIVFTDNAAASPLETAAEIVRIPDLSAARIITELEKRGFERLLVEGGPRTLGLFFAEGLVDTLRMAVNPAVRVGDPHAPRFEPPFDPARFPQQRRRLEGMEVTTYTLHPDRTEEDLHYLRQAIALSRRCTPCATSYRVGAVIVTRSGDRFTGYTHETSPTHHAEQEAILKATAAGADLHGASIYSSMEPCSTRSSEPESCSELILRHGFSRTVFALYEPSCFVCCEGAVRLRKGGVEVRVYPQLAGEVLAINGHLGLHE
>NZ_AP019739.1|WP_141418726.1|1508726_1510169_+|TolC-family-protein
MKKVTLVMLALAAVMQLPAQEQGRTLSLEEALEMTLSDNPAIRAAEFNRRAAQQERRAAIGLRMPQIGITGSYAYLGKDIEIDLNNMKAPVQNLAGQILQSGMIPSDYIPSISQMLSGAMAASWALPLQDRSLGFVGGDVTVPLWMGGKINAANRAARINEQTARSQGIQQRNALVSELVERYYGLALAQQVVVVRQQVVDGVRKHLEDAAALEAQGMISRSEKLYVEFKMSEAERDLQNAQSQVETIAAALNSTIGRTDDYLPVTAMFILERIEPLDHFRTLAAERNPLLDQVDQKRRLAYEGVRAQRSSFLPQVVAMGGMSFYDYQVSKVLPRWAVGVGVNFKLFDGLNREYKYSAAKQTVRRVEALQDKAGNDISVLVEKLYNQMENYRTQMASIEASLAFAEEYLKTKNAAFLEGMSSSTDLIDAELNLAKVKTERIEAAYRYDVSLAQLLEAAGISDEFTAYMRRQDARRITFEK
>NZ_AP019739.1|WP_141418727.1|1510185_1511172_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MKKKNIIAVLVAVVVIIAAVLLVSRYLKARTPILLQGTTECTTYKASSKIAGRIVDMKVEEGQRVERGELLYTLSTPELDAKLQQAEAVRSAASAIDQKVLSGARVQQIEAALNMWQQAQAGRELAKKTFDRVKALYEQGVVPAQKFDEAQAQYNAMTATASAAKAQYDLAVDGASKEEKAAAAAQVRQAAGVVSEVESYLSDAMVYSPVTGEISTIIAEQGELVGSGYPVVAILDMSDMWVMFNIKETLMPKIRMGKRLRGYVPALDRDVDFHITYIAPQADFATWAATRTQGGFDIRTFAVKAKPLGAEEGMRPGMSVLVDWDAIE
>NZ_AP019739.1|WP_019129491.1|1511184_1512363_+|ABC-transporter-permease
MRNYFKETDQVVRRELRRIVRQPMYWVLMVVLPVVSFAFFAVIFERGVARNIPIAVLDEDHTTLSRKVTQMIDDTPTAMVSYEVQSMEEAQRLMREGRISAIVHIPAFFEKNILSNSQTHIECSVSGTNITVNGLLSKDLQTAVTTFQAGVQLQLLMKQGLTEKQAMAQIMPVRFVKHVLFNPYINYSYYLSPSFMPMMLMIFAMLVTIFAIGTELKAGTAREWLDTAGGSVFPALVGKMLPLVVMMLLMTLMMFLILFKIVGVPLNGSLTALLFGCMLFVLAYMAIGVLIVTLLSNLRLSLSIGGGYSVLAFTFSGLTFPMMAMYPWVQAFSKIFPFTFYTDIFIDQALRGAPVVDSLWDMGYIALFIVLPMLCLPRLRKICSDEKYWGRM
>NZ_AP019739.1|WP_019129490.1|1512365_1513577_+|ABC-transporter-permease
MGRIKEILQAYRTELASVIRNEYKAVFTDGGVLLVMVLAIFIYSTLYASAYAPEVLRNVPIGVIDESQTPSSRELIRTFDAGPNTYVAYEPSGMEEAEELFFARKIYGVVYIPQDYEKQLLGGSSAAVSLYVDASYFLMYRQVFQELVTGIGQTGAMVQFQRLIAKGADIPQATAATQPVIYQSHNLFIPYLGYGSFIMPAIIIVIIQQTLLIGIGMIGGTWREFGLYRKLIPANCKRMYTLPIVLGKALVYISIYAVTLLYIMTVHYKLFHYPSNGSTEAVVGLLVPYLLACIMLGIAISTLFRYREQSLLLLFWTSIPILLLSGASFPREAIPEWLYTLGQVFPSSSGVNAFIRIRTMGASLRDVMPELRILWAQVFVYGGLACIGIHVILTRQKQDEGGQ
>NZ_AP019739.1|WP_141418728.1|1513666_1516687_-|outer-membrane-beta-barrel-protein
MRRTILLFVTLFTAMEIYAQSGSVTATVIDASTREGVPGAVVEFAPADPAAQKRYFTTGYKGRVEATVPYGTYKVSVSFLGYETLEKELKLSAAKKSLGTLELAPSSTEIEAVVKEVKSMRTSQKGDTVSYNAGAFKVTADADVEGLLKKMPGITITDGEVEAQGETVKKVFVDGKEFFGEDVTSAIKSLPAQAVDKVEVYDKLSDAAEFSGMDDGEGYKAINIVTKPNMRQGQFGKLYAGYGYQPETEGTTSNHKYNVGGNVNLFHGSSRVSVIGLFNNVNQQNFSFEDILGVSGGSGGRGGVGALMVRPQSGVASVNSFGVNYSDSWGKTGRQDKVTLQASYFFNRTTTKNYSTIDKWYETPSPIDTLHTDGYSNNTNGNHRLNARLEWRISENQSLMSRTGLSFQSYDPYSTTYGHQWGESGLRVVDNFSDGGRTGVNLNQYLSYRTKLGKDGRTLTLDGSVRYRNNRGDTDSYSNQARGIDPDLIVVPTDTLLLRYQRAHSPSFSYNLRGDVTYTEPVSQYAQLSLQYRVAYNYQESDKKVYVTPDDRFETAGVEPDPSLSQSSNTGYLTHRIGPGFRIVKGKNRFVANVSYQRAQLTGEVLSATKVMGAGDDAKTSHGFNNLTYFLMGQLNINKENSIRLFINSSTDNPGIGELQNVYDISNAQSISKGNPHLRPSYSNNVRFHYVNSNVEKGRTFMWMFSMQNTSNYITSSMAYDVEVEVPTGEVDGGGDPVTETYNPHTYSTYTNMDGYWNLRTHLSYGLPVSFLKSNLNVMAGVNYTLTPTLVARKATDGSVYLDNGEIVGGERNDASRLSYDFRAVLGSNISENVDFTLSWHGAYNIAKNSLVVNDSDNKNRYFNHVATAAMKFVFLKSFTFTGNVSYQQNIGFTNDYDNSYVLCNVYLGKKVFRNRRGEVMFGVNDLFDQNTAFSRTTGSGYTQNSINSVIGRYYTVQFVYNLRNFGKRGSKDIKDYDGMGALGGNRRGVGRPPMGPPPGGRGPMF
>NZ_AP019739.1|WP_141413329.1|1517340_1518108_-|response-regulator
MKAVIIEDETAAAVNLQSILHRVAPAVEITAVLEGVEESVEWFGTHPQPDLVLMDIHLADGEAFRIFERVSLTAPVIFTTAYDRYALEAFKVDSIDYLLKPIKEEEVRRALEKLRRLSGLERSRYSERVERLAERANERQQVFLVRVRDKFIPLQRERIAYCYTSDERVTACTLDGEKYPLDKPLETLQTLLPASDFFRANRQFIVARQAVAEIAVWFGSRLALRLSVETPERIVISKARVPEFKRWLTSVHPAD
>NZ_AP019739.1|WP_141418729.1|1518104_1519481_-|termination-factor-Rho
MSRPSKYSGIVVNLLIAVAISLVVNFSYVLLLVVEKSDDRHPPFSRELRTDREIVRVEGDVWISPDGHGYLLYVSPERLSDGDAAATGLAEVAPARDSVYIPRNSARFLRLRSGDHLLADALESHRSGGRLVLGQVLERNGEPFDYGVIFERPQEGVIFALQLFYFFVLAFLLLSLLRLGDRVRPMSGFFKRGLLCAGLAVGLYFIAPVVRWRTHELTILALSGSWLDYNLIMKCSFTLVVVLLYGQISRLLRQRQAMEVENEQLKSENLTTRYNMLVSQINPHFFFNSLNSLAMLVREGDEQKALTYIDQLSFSFRYIIRNGQNMLTTLAEELRFAEAYGYLFKIRYADKLFFDVDVAPKYLDYRLPVLTLQELLSNAVKHNAITKRRPLRVSIRVENGQLVVSNPLLPKLDAEPCTGIGLHNLDSCWQLITGHGIRIDRSGEIFSVCMSLLKPRTK

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Crispr_ID: NZ_AP019739_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_11

1610396-1610510

Orphan

Consensus_repeat	Method
TCGTATCTTTGGCTGACACCTTAGATACTCCGCCTCGGCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_11

>merge|NZ_AP019739|11|1610396-1610510|CRISPRCasFinder
TCGTATCTTTGGCTGACACCTTAGATACTCCGCCTCGGCAAAAAGCAAATAAATTTGATATTGCCTTCGCTTAATCGTATCTTTGGCTGACGCCTTAGATACTCCGCCTCGGCAA

>NZ_AP019739|11|10|1610396-1610510|CRISPRCasFinder
TCGTATCTTTGGCTGACACCTTAGATACTCCGCCTCGGCAA	AAAGCAAATAAATTTGATATTGCCTTCGCTTAA
TCGTATCTTTGGCTGACGCCTTAGATACTCCGCCTCGGCAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141419654.1\|1603288_1606057_+\|TonB-dependent-receptor-plug-domain-containing-protein	unknown	unknown	gnl\|CDD\|369481
NZ_AP019739.1\|WP_141418772.1\|1618095_1620051_+\|DUF3857-domain-containing-protein	unknown	unknown	gnl\|CDD\|379003
NZ_AP019739.1\|WP_141418768.1\|1606456_1607983_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_081584203.1\|1608020_1609238_+\|DUF4876-domain-containing-protein	unknown	unknown	gnl\|CDD\|379795
NZ_AP019739.1\|WP_141418773.1\|1620054_1621950_+\|DUF3857-domain-containing-protein	unknown	unknown	gnl\|CDD\|289722
NZ_AP019739.1\|WP_141413385.1\|1612742_1613351_+\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|376491
NZ_AP019739.1\|WP_141418766.1\|1600973_1601861_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_AP019739.1\|WP_141418767.1\|1602496_1603090_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141413390.1\|1622544_1624287_-\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_AP019739.1\|WP_141413379.1\|1606067_1606454_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419655.1\|1617359_1618007_+\|O-methyltransferase	unknown	unknown	gnl\|CDD\|366722
NZ_AP019739.1\|WP_026074697.1\|1622031_1622352_-\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|212138
NZ_AP019739.1\|WP_141418765.1\|1600295_1600967_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141413384.1\|1611384_1612746_+\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|182787
NZ_AP019739.1\|WP_141413383.1\|1610573_1611287_+\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|234595
NZ_AP019739.1\|WP_141418770.1\|1613347_1616137_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_AP019739.1\|WP_141418771.1\|1616142_1617360_+\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685
NZ_AP019739.1\|WP_141418769.1\|1609505_1610288_-\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_AP019739.1\|WP_026074700.1\|1601943_1602513_-\|peptidase	unknown	unknown	gnl\|CDD\|374499
NZ_AP019739.1\|WP_019129408.1\|1609305_1609491_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377101

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141419654.1\|1603288_1606057_+\|TonB-dependent-receptor-plug-domain-containing-protein	gnl\|CDD\|369481	pfam07715, Plug, TonB-dependent Receptor Plug Domain. The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.	1.5659e-11
NZ_AP019739.1\|WP_141418772.1\|1618095_1620051_+\|DUF3857-domain-containing-protein	gnl\|CDD\|379003	pfam12969, DUF3857, Domain of Unknown Function with PDB structure (DUF3857). This family is based on the first domain of the PDB structure Structure 3KD4(residues 1-228). It is structurally similar to domains in other hydrolases, eg. M1 family aminopeptidase (3ebi, Z=10, rmsd 3.6A for 152 CA, seq id 12%), despite lack of any significant sequence similarity.	4.79957e-07
NZ_AP019739.1\|WP_141419655.1\|1617359_1618007_+\|O-methyltransferase	gnl\|CDD\|366722	pfam01596, Methyltransf_3, O-methyltransferase. Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.	4.78558e-45
NZ_AP019739.1\|WP_141418773.1\|1620054_1621950_+\|DUF3857-domain-containing-protein	gnl\|CDD\|289722	pfam12970, DUF3858, Domain of Unknown Function with PDB structure (DUF3858). This family is based on the third domain of the PDB structure 3KD4(residues 410-525). It is structurally similar to part of neuropilin-2 (Z=4.6, rmsd 3.6A for 83 CA, 7% seq id). This domain and the second domain appears to be part of peptide-n-glycanase (1x3w, 2g9f).	0.00118906
NZ_AP019739.1\|WP_141413385.1\|1612742_1613351_+\|YigZ-family-protein	gnl\|CDD\|376491	pfam01205, UPF0029, Uncharacterized protein family UPF0029.	9.76088e-51
NZ_AP019739.1\|WP_141418766.1\|1600973_1601861_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.94213e-62
NZ_AP019739.1\|WP_141418769.1\|1609505_1610288_-\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	9.50399e-111
NZ_AP019739.1\|WP_141413390.1\|1622544_1624287_-\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_AP019739.1\|WP_141418770.1\|1613347_1616137_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_AP019739.1\|WP_026074697.1\|1622031_1622352_-\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|212138	cd11531, NTP-PPase_BsYpjD, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs. This family includes a putative pyrophosphatase Ypjd from Bacillus subtilis (BsYpjD) and its homologs. Although its biological role has not been described in detail, BsYpjD shows significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, BsYpjD contains a single MazG-like domain.	5.41748e-42
NZ_AP019739.1\|WP_141413384.1\|1611384_1612746_+\|signal-peptidase-I	gnl\|CDD\|182787	PRK10861, PRK10861, signal peptidase I.	1.02749e-18
NZ_AP019739.1\|WP_141413383.1\|1610573_1611287_+\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	8.74973e-60
NZ_AP019739.1\|WP_141418771.1\|1616142_1617360_+\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	6.69308e-69
NZ_AP019739.1\|WP_081584203.1\|1608020_1609238_+\|DUF4876-domain-containing-protein	gnl\|CDD\|379795	pfam16215, DUF4876, Protein of unknown function (DUF4876). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 392 and 433 amino acids in length. There is a conserved NNS sequence motif.	4.85875e-53
NZ_AP019739.1\|WP_026074700.1\|1601943_1602513_-\|peptidase	gnl\|CDD\|374499	pfam16357, PepSY_TM_like_2, Putative PepSY_TM-like. This is a family of bacterial proteins with three PepSY-like TM regions.	1.10635e-13
NZ_AP019739.1\|WP_019129408.1\|1609305_1609491_-\|hypothetical-protein	gnl\|CDD\|377101	pfam03699, UPF0182, Uncharacterized protein family (UPF0182). This family contains uncharacterized integral membrane proteins.	0.00866085

>NZ_AP019739.1|WP_141418769.1|1609505_1610288_-|tRNA-pseudouridine(38-40)-synthase-TruA
MRYFVELSYNGGRYCGWQRQRDAASVQETLERALSTLLREPVEVTGAGRTDTGVHAAYAVAHFDVAAPLTDPEHTAYKLNCLLPDDVAVFGVAPVADDAHARFSAAEREYRYFIESRKNPFTRRAAWHYYRPLDVERMDRAAASLLEYDDFTSFAKLNSNNKTNICRIVRAGWEESPEGVYRFTIRADRFLRNMVRALVGTLVDVGRGRYDVEEFRAIVESRDLSRASGGAPAEGLYLWDVAYPAGVFRRGERTRNLLFN
>NZ_AP019739.1|WP_019129408.1|1609305_1609491_-|hypothetical-protein
MGTILYLVGLVCAVLAVLDIFKKNISTVGKVIASVLVLLTSWVGLLVYYFYAKDHLEEWFK
>NZ_AP019739.1|WP_081584203.1|1608020_1609238_+|DUF4876-domain-containing-protein
MRKLFAMLTVVALATGMTACSDDDGTETPKDPTTTNFNLRARGGNVMVTLTTSDYTIDIPAADADWIGLSEQSQGEVVVLSVKPNTTGAERSTTVTLAEKTTGTTLAYMNIKQSENSLYSGDFLIEESFFTSCPLPATGKVDKAHGDQYIKIRNNTDQDLYADGLLIITSSKITSVQNISFNEGEDPRPNYCIVDEILCIPGDGDDVLVKAGESLLICNNAQNHKATNPNSFDLTSADFEWYNESTVESMLDIDNPEVDNLDIWYTYTKSVIMLDAAGKRSCALAIPPIGMTRDRFLADYAFTGSYIFHSPNGKDYDMTFKNCFKVPNSWIVDAVNLGVSSEYLTNPWDTELDAGYTYACETSSDQTSYGLSVRRKVAADGKLVDTNNSTNDFTPRATPSLSEIQ
>NZ_AP019739.1|WP_141418768.1|1606456_1607983_+|hypothetical-protein
MKPLRLLLLCLLPLPLWSEAQTAAVRDSLGILRRAEFHNAPLATLDASAYESSPAAMLYRYPVSYSTLRLQGDLRSESRPILQPEGDGALVGTFRADSYLRLDEQSVVTAGASYERGRTDNVRWNSTADYRLLRPFVLADSVGGDLSTEEYAFRGAYVRRDGRINYGIGINYRARHEFRQIDPRPHNIVNDLTGTIGAGFSTDRSLIALTARGRIYKQSQEVGFFDERGANTVEFLMTGLGNYFARYVGGEDQSLFYKGKEYALSLTAVPSRTCGWSALLQYERFSNRNIFSELNYAPAGRLVTQTLSGSVARRYERGGFAVEGSYELRQGFENVVDNGETADYRILGEFAMYRNRTLRLAAGGMVTWNRPQTDYTLAPSVGYFRTSADYPYPKREIALSTASAGCDLHLTRHGQRGTLRATVGGRYAVNLTRRTLLTDSRLDPDIGAMLFDSVDRMTADAVELTAALRAERELRRSLALFVDASWRPGIYMDGVRVHLATIACGICF
>NZ_AP019739.1|WP_141413379.1|1606067_1606454_+|hypothetical-protein
MRRLLLLFPLLSLCSTACESDGRELFTQLSVRFILPDDRPVERIELLSDISYCENINTKERVFFTVLDGRSATLTLQKGVYTLIVEANLHYTDGTVQYVRNADHNTPSEALAWMDDRSSIVLLLKYVN
>NZ_AP019739.1|WP_141419654.1|1603288_1606057_+|TonB-dependent-receptor-plug-domain-containing-protein
MLGLLLASAAEAQTTDEARLEVTVTDAASGEALGYAVCSLRPKEGNGKERAAAADARGVCLLEGLKPGRFELRLLYMGHVFLQGELQLPAGLTRRRIRLDIDPVAIGEVLVTAAESKGPTSSSKIGREAIAHIQPSSIADLMELIPGGRATDPSFGAPQEIRLREADPSSSANYATSALGTQIQVDGIPISNDANLQYSTSYGSIQEYANVNRGVDTRAISTDDIESVEIVRGIPSVEYGDLTSGLVKVKRREGGRDLTARFKADMSSKLFSVGKGFERKGEGDAERTTLNINADYLTAASDPRNPRQSYQRLTGSVRFGRHWQGSAYRYSAGGSLDYTGSFDDKKSDQDLDNGLGGPVERYKSNYNRTQFAATFAVEARHRQFFHSLDLTASFSAEFDRIDRWRFVETGSDFAKTWGTEPGEYDAVIIPASYDATLLVDGKPFYGYAKAVATFNADTERSRNTLRVGADWSMDKNYGRGLVFDVARPFSPQMDSRPRAYDAIPALHKLSLFLEDATTLALGDFRVEATGGVRAASMFNLGRRYTIQGKFYFDPRANVVVALPRFHVAGRNLSLRLGGGVGWHTKFPTMDSLYPDTEYFDFTQLNYWPANPALRRINLRLYTLDPTNYDLRAARNFKWEVRLDAGWNDNQLSVTYFREDMTSGFRTTSDYRSFTFRDYDETAIDMEQLDGPPSLDGIPYTEERRLGGYSRSTNGSRTEKSGIEFAFTSQRIRAIATRITVTGAYFRTNYSNMHPEYLLPTSAPGGQTYPYVGYYFSTDGYLREMCNTNFLLDTQIPRLKLILSTSFQCMWFLGSRNTPVSAWPISYLDENLVSHPFTAESAADGLLSALVRDSDPTLWRYVTTPFSMNVNLKITKKLYRDKMAVALFVNKLLDYTPDYHTSDGRHIRREVTPYFGMELNIKL
>NZ_AP019739.1|WP_141418767.1|1602496_1603090_-|hypothetical-protein
MKTNKLMLSATAFLLLLAGVGCGNRTTKAESAVAAAEAAVGEALQIDDLLAGADSLAGKEVWIEGVCTHACKHGARKIFLMGSDDTQTIRVESGKLGKFDPQCVGSIVRVKGILREQRVDEDYLRSWEEQVRTQAGEQHGTTAAGCDSEKKARGETAATVEGRIADFRRKIAERNAAEGKPYLSFYFVEAQSYEFDR
>NZ_AP019739.1|WP_026074700.1|1601943_1602513_-|peptidase
MNSTANRLRRWSRNVHRELSFFFSGMLLIYAVSGLVMNHRDTINPNYSVEQRRYVVGEPLPARDRLTRDDVVRLLAPLDEADNYTKHYFPESDVLKVFLKGGSSLTVRLSDGEAFYEKLTRRPVLGAMTRLHYNPGRWWTWFSDLFAVGLVAIVASGLLLLKGPKGLRGRGGVELAAGIAVPLLFLIFF
>NZ_AP019739.1|WP_141418766.1|1600973_1601861_-|ATP-binding-cassette-domain-containing-protein
MSAIIECRNLTHYYGRRLIYRDLSFDVPQGRILGLLGKNGTGKTTTINILSGYLKPRSGECRIFGQEVQNLDPVLRRNIGLLIEGHVQYQFMTIEQIEKFYSVFYPAWRRDAYYELMRKLKVAPGQRISRMSCGQRSQVALGLILAQNPELLVLDDFSLGLDPGYRRLFVDYLREYARAESKTVFLTSHIIQDMERLVDDCIIMDYGSILTQRPVAELLAEVRRYGFTVPEGYEIPDAKEFYHPSVIRNRAELFSFLPPAEVERTLRRLQVPYGEFTSEQVTSLEDAFIGLTGKY
>NZ_AP019739.1|WP_141418765.1|1600295_1600967_-|hypothetical-protein
MLRAIFYKEWLKTRWYYLVAVLLSLGFVGYVLLNFFRAAGLKGIAHLWEVMLLRDAVFVDLLQFVPLVVGLLFAVVQFVPEMQRKCLKLTLHLPCPELRMIGAMLLYGVLLLGALFAVSLGVLFVAFRAVLAPELVRHILLTAAPWYAAGIAAYLLAAWICLEPTWRRRLLYGAVAACVLRLFFLAPAPEAYDGFLPWLTLCTLCTASWSWWSVVRFKEGRQD
>NZ_AP019739.1|WP_141413383.1|1610573_1611287_+|4-hydroxy-tetrahydrodipicolinate-reductase
MNAAIIGYGKMGREIERLLVERGHGVGLIVDADNRGDLDAAHLRGIDVALEFTTPATAYDNIRACIDAGTPVVSGTTGWTDRLDELKTRCKERGGAFFYASNYSLGVNLLFRLNRQLAEMVGRVGGYDVRIEEVHHTQKKDAPSGTAITLAEEIIDRIGTKERWVNRPAADPSELAIASIREGTVPGIHTVTYTSADDVLTLRHEILNRRTLALGAVIAAEFLNGKRGVYTMDDLLK
>NZ_AP019739.1|WP_141413384.1|1611384_1612746_+|signal-peptidase-I
MEKIKAILRNKWFGFIFWSLLYILWFVIWTGNLWLLLGELVIVDLYFTHFLSRLIGRRNREWCRRSPTYKFIYEWVNAIVFATVVASLIHIFVFQMYVIPSSSMESSLLIGDYLYVSKVAYGPQMPNTPVSFPFVHHTMPFSQTKKSFSECIRWPYHRLKGLRSIERNDVVVFNFPAGDTVLLQRQDATYYDVLREYQRTLGARAGREKLFRDYTVITRPVDKRENYIKRCVAIAGDSLKIVGGEVYVNDEPQAPVAGKQYMYTVMTSSPLSKYAIDKLGITEWSGGNGSNYYMLLDDERAEELRRMGNVLAVERFIYEEPNREVYPHDLTLGWNQDNYGPIWIPARGATIPLTPENMRLYRRCIEVYEGNRVEELPDGRVLLNGQPAADYTFRMNYYWMMGDNRHNSADSRFWGFVPEDHIVGRASFIWLSLDAQKSFPSNIRWNRLFTKVK
>NZ_AP019739.1|WP_141413385.1|1612742_1613351_+|YigZ-family-protein
MTTPADDTYLTIEAPAEAIYKEKSSKFLAFAYPVADEEEIRSRLEALRKRYYDATHHCYAWRLGPHGEAFRANDDGEPSSTAGRPILGQLLSHETTDCLIVVVRYFGGTKLGVPGLIAAYKESAAEVLAAARIVQRTVDRRIAVTFSYAAMNDIMRIVKEEQPAVESQRFDNLSSIVLRIRASRAERLTERLRKVEGATIET
>NZ_AP019739.1|WP_141418770.1|1613347_1616137_+|excinuclease-ABC-subunit-UvrA
MNEPKSIHIKGARVHNLRNIEVEIPHDTLTVITGLSGSGKSTLAFDTIFAEGQRRYVESLSAYARQFLGKIDKPDVDLITGIAPAIAIEQKVNTRNPRSTVGTTTEIYDYLKLLFARIGRTFSPVSGREVKCYDVDDVAQYVLALGQGAKALVAAPLVAAEGQGVIEKLTLLMGDGIQRVQYDGRTRFIEELLPELDPAVRPDELSVIVDRLRVASDEEFATRLRDSVARAFAYGDGVCRILTDEGAEEFSSRFEADGIAFAQPTEHLFSFNNPLGACPRCEGYGKIIGIDEDLVIPDKSKTIYEGAIACWRGETMRLWKEKLVENADKFDFPIHTPYHELTPEQKRLLWTGNEYFYGLDSFFEYIDSERRKIQFRVMKARYTGKTRCPECGGSRLRKEALYVRVGDRTIADLVTMNVDALLVFFKELQLDAHDTTTARRILTEIVNRLQYLADVGLGYLTLDRLSSTLSGGESQRINLATSLGSNLVGSLYILDEPSIGLHPRDTNRLVGVLKQLRDIGNTVIVVEHEEEVIRAADWIVDVGPEAGYNGGEIVFCGPAKKLPACRKSLTADYLAGRRRIEPPSTPRGWSHSIVVKGARENNLQNIDVRFPLGAMTCVTGVSGSGKSSLVKGILYPALRRTLFDTGIKPGDFDALEGDVQLLKSVEMVDQNPIGKSTRSNPVTYIKAYDEIRKLFADQPYAQHNGMTPSHFSFNIAGGRCEECQGEGVIKVSMQFMADIELKCEACGGRRFKEEVLEVKYRGRSIYDVLEMTVDDAVAFFGEDKANAVCRRIVDRLLPLQEVGLGYIKLGQSSSTLSGGESQRVKLASFLAKDAVQGNVLFLFDEPTTGLHFHDINKLLAAFDALIRKGHTIVVVEHNMDVIKCADWVIDLGPEAGDRGGRVVFEGTPAQLETCAESYTGQFLKLRTKL
>NZ_AP019739.1|WP_141418771.1|1616142_1617360_+|insulinase-family-protein
MKEFHTYTLPNGIRGIHRQVRGNVAHCALVVGAGTRDELKSEYGLAHFAEHAFFKGTQRRRAYQVNCRLENLGGELNAYTTKEDTTLHATVLRGDFAKAVELLADVAFRSTFPERELEREREVIFDEINTYKDSPADRIYDDFEDLLFAGSALGHNILGTKAALARYRSEHIHAFVRRTHTTDQMVFSSIGNIAPRRIEAIAARYFADMPATVRSFCRTAPAPVAPFERSIARHTHQSHCIVGARAYGILDPKRLPLALLVNILGGPSANSMLNVTVREKHGLSYSIEGSYTPYGDAGIVAIYFSSDHDNCDRCLELVRGQIDSLRTRRLSTRRLALAKKQFVAQLAISMESNEGYMLGAGKSYLVHSEVDTMEEVYRKISDLQAGELLEVANEVLASPSLLVYR
>NZ_AP019739.1|WP_141419655.1|1617359_1618007_+|O-methyltransferase
MDALEKYVDSLSTPESELLRALDHETHMQTIQPRMLSGHIQGKLLEMFVRMLRPRSILEIGTFTGYSALSMAAGLGEGATLDTIEVDDELEELPQRFFDRSPCGGKIRLHIGSALDIAPTLGGPFDLVFIDGDKREYPAYYRMLMGDDTGRPLVESGAFLLADNILWSGKVVAPVAHNDLHTQRILEFNRTVADDPRVENVIVPLRDGLNLIRVK
>NZ_AP019739.1|WP_141418772.1|1618095_1620051_+|DUF3857-domain-containing-protein
MKTYPFLAVFICLCVNTAAQEYSFKYGKITPDELRMTLYEPEPDAPAVFIYDDTDIHYSFGNSIQLLCYRTVKIKVFKDEGVKWGDVAIDFGNYQLSKEVVSRIDAAAYNLVDGKTVKTQLKRQNIFEEVLDEHTKRLKFSIPEVRAGTVIEYRYLLTSDFIGQIPDVDVQHAIPVVRSTAQISIPEYFTHHIHTRGYLTLPVKKELENGGAAGFSGFSYTNTKYICNIDRVPSLRKEPYVWHLDDFRAGLEFEINGLEIPGSLYKSFTRTWADVYESLDRSEFGRYADIRNPFKDEVAAIVARNADDERRQLHEILKFVQSRIAWDGTYRLTPESSPHAAVDKRRGDSGSINFILAAALRDAGFKPEIILLNPRSAGRLPLTHATDRIRTFVLRTKLKSGETVYLDATDLHSDVNVLPTQLLVDHARLYSPEHPFENWINLSSPAQSVVLSQITARLTEEGELECTETDTETNQAAYDLSRRYSRSENHDTFVQEYEQRAGITISELTVDGLNSAKARMKLNFRKPVDSGGDFLYICPTIVPFIEKNPFTSQKRQLPVEFSYPYRYRIIVSLMLPEGYTVEELPKSQRLSACDEGIACTMQLQQQGALMQCLFEFDLSRIIFPATEYTDLSAFYGFVMDMCNSRIVLKKS
>NZ_AP019739.1|WP_141418773.1|1620054_1621950_+|DUF3857-domain-containing-protein
MRSRLLPCLLLTLGSTAAGTAQEYSVATLADSLRQNAQAVVRLYETDFQYNSPSSATARHDIVVTLLDRRGARHADLVCYVDMFSSLKSFSAEICDASGRVIRKLGKGDLNYTEYSQHLADDAAYYWLEPPLSVFPCTVRYRYETAHKNGMFGTLRFVPLSTDIGVALEKARFRLSTPAGYAFNCRCTPFPVEPVRHTDRGRDNYEWTFPSRTAVLDEPLIPPARERLPILYFAPSEFTYDKTQGNMQDWPRFGVWMDGLLAGRGQLPPALQAEIHDLTDTIPDKRRKIEALYRYLGRTTRYVSIQLGIGGWQPMDAATVYANKFGDCKALSNYLHAMLAACDIESFYTIIHTQNKHIPRDFATPAIANHAILGVPCQRDTLWLECTNTDVPFGYVHQSIAGHDAVICHDGKAEVVTLPAYADSLNTECQRIDVRLDEAGNASLSLSSVSRARQYEWTRPILDLARDKQADFLRRSFQLPLAQVDSLRCEEVLDKPLPEMHIRASITALRYANKTGSRLFVPVAPLRSGPGRFTAERRHDLWIDKGYCDTDSLTLHLPEGYVVEALPKSVTIENRFGKVAFEALCSGDRLHIRIRLLRRSGRYPQSEYAAFREFMQAVDRVYSAKIVLRKV
>NZ_AP019739.1|WP_026074697.1|1622031_1622352_-|nucleotide-pyrophosphohydrolase
MELSELQQRVDTWIKEYGVRYFSELTNMAVLTEEVGELARVMARKYGDQSFKAGEKENLADEMADVLWVLVCLANQTGVDLTRAVEANFAKKSARDAERHRNNPKL
>NZ_AP019739.1|WP_141413390.1|1622544_1624287_-|phospho-sugar-mutase
MANELEQLVLSKAQKWLDGDYDEATKKQVRYLMDHDRKELTESFYKDLEFGTGGLRGIMGVGTNRMNVYTVGMATQGLANYLKKNFAGERIRVAIGHDSRNNSRMFAERVADIFASNGFTVFLFDKLRPTPELSFAIRELKCHSGVVVTASHNPKEYNGYKAYWTDGSQVTAPHDRNIIAEVEKITSIDQILTGANPGNITLLGEEFDEIYLNKVHTLSLSPESVGKFHDMKIAYTPLHGAGVRLVPASLRKWGFTNVSLVEEQAVIDGNFPTVESPNPEERKTMAKAIELGSRLGADLVLATDPDSDRIGVALRNAKGEYVLLNGNQTLSLIMAYQLTRWSELGRLDGKEFVVKTIVTSQMPNVMAAHFGVKCYDCLTGFKYIARIIRNNEGKATYIGGGEESFGYLAGDFVRDKDAVSACSLVAEAAAWTRDTMGLTLYEWLQKLYVEFGFFREGLVSVVRKGMEGAAEIQQMMVDYRADPPREIAGSPVVKINDFKLLESTDVRTGAKTPIEEEASNVLQWFAADGTVVSVRPSGTEPKIKFYFGVRAELESVADFDRVEAGLDAKIETIKKELKLV

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Crispr_ID: NZ_AP019739_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_12

1674980-1675175

Orphan

Consensus_repeat	Method
GCAGAAGCAAGCGTTAGCTTGATTATGCCGAGACGAAGTATCTAAGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_12

>merge|NZ_AP019739|12|1674980-1675175|CRISPRCasFinder
GCAGAAGCAAGCGTTAGCTTGATTATGCCGAGACGAAGTATCTAAGACGCAGTCAAAGATACGAAAAGTCGAGCGCAGAAGCAAGCGTTAGCTTGATTATGCCGAGACGGAGTATCTAAGACACAGTCAAAGATACGAAAAGTCGAGCGCAGAAGCAAGCGTTAGCTTGATTATGCCGAGACGGAGTATCTAAGAC

>NZ_AP019739|12|11|1674980-1675175|CRISPRCasFinder
GCAGAAGCAAGCGTTAGCTTGATTATGCCGAGACGAAGTATCTAAGAC	GCAGTCAAAGATACGAAAAGTCGAGCGCAGAAGCAAGCGTTAGCTTGATTATGCCGAGACGGAGTATCTAAGACACAGTCAAAGATACGAAAAGTCGAGC
GCAGAAGCAAGCGTTAGCTTGATTATGCCGAGACGGAGTATCTAAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019129352.1\|1672134_1673253_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_AP019739.1\|WP_026074690.1\|1667742_1668222_+\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	unknown	unknown	gnl\|CDD\|376811
NZ_AP019739.1\|WP_141413412.1\|1665292_1666738_-\|beta-Ala-His-dipeptidase	unknown	unknown	gnl\|CDD\|349885
NZ_AP019739.1\|WP_019129356.1\|1669019_1669265_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418797.1\|1666828_1667737_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|224629
NZ_AP019739.1\|WP_141418798.1\|1671255_1672059_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315987
NZ_AP019739.1\|WP_019129343.1\|1680963_1682229_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NZ_AP019739.1\|WP_019129348.1\|1676120_1676432_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_162829814.1\|1680230_1680938_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_AP019739.1\|WP_019129346.1\|1678237_1679257_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_AP019739.1\|WP_026074689.1\|1669424_1669625_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_AP019739.1\|WP_141418801.1\|1676507_1678238_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173842
NZ_AP019739.1\|WP_141418796.1\|1662741_1665177_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|379720
NZ_AP019739.1\|WP_141418803.1\|1683031_1685098_+\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_AP019739.1\|WP_141418799.1\|1673598_1674786_-\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|366411
NZ_AP019739.1\|WP_019129349.1\|1675916_1676111_+\|YtxH-domain-containing-protein	unknown	unknown	gnl\|CDD\|378938
NZ_AP019739.1\|WP_141418800.1\|1675329_1675818_-\|DUF1273-family-protein	unknown	unknown	gnl\|CDD\|377733
NZ_AP019739.1\|WP_141418802.1\|1679277_1680156_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NZ_AP019739.1\|WP_026074688.1\|1669938_1671171_+\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|223283
NZ_AP019739.1\|WP_141413674.1\|1682566_1682884_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_019129352.1\|1672134_1673253_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	6.89435e-155
NZ_AP019739.1\|WP_026074690.1\|1667742_1668222_+\|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase	gnl\|CDD\|376811	pfam02542, YgbB, YgbB family. The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis).	1.53851e-94
NZ_AP019739.1\|WP_141413412.1\|1665292_1666738_-\|beta-Ala-His-dipeptidase	gnl\|CDD\|349885	cd03890, M20_pepD, M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide. Peptidase M20 family, Peptidase D (PepD, Xaa-His dipeptidase; X-His dipeptidase; aminoacylhistidine dipeptidase; dipeptidase D; Beta-alanyl-histidine dipeptidase; pepD g.p. (Escherichia coli); EC 3.4.13.3) subfamily. PepD is a cytoplasmic enzyme family characterized by its unusual specificity for the dipeptides beta-alanyl-L-histidine (L-carnosine or beta-Ala-His) and gamma-aminobutyryl histidine (L-homocarnosine or gamma-amino-butyl-His). Homocarnosine has been suggested as a precursor for the neurotransmitter gamma-aminobutyric acid (GABA), acting as a GABA reservoir, and may mediate anti-seizure effects of GABAergic therapies. It has also been reported that glucose metabolism could be influenced by L-carnosine. PepD also includes a lid domain that forms a homodimer; however, the physiological function of this extra domain remains unclear.	0
NZ_AP019739.1\|WP_141418797.1\|1666828_1667737_+\|restriction-endonuclease	gnl\|CDD\|224629	COG1715, Mrr, Restriction endonuclease [Defense mechanisms].	6.6226e-100
NZ_AP019739.1\|WP_141418798.1\|1671255_1672059_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.000258319
NZ_AP019739.1\|WP_019129343.1\|1680963_1682229_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NZ_AP019739.1\|WP_162829814.1\|1680230_1680938_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	1.08117e-39
NZ_AP019739.1\|WP_019129346.1\|1678237_1679257_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	8.39997e-110
NZ_AP019739.1\|WP_026074689.1\|1669424_1669625_+\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	8.90944e-24
NZ_AP019739.1\|WP_141418801.1\|1676507_1678238_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.81676e-149
NZ_AP019739.1\|WP_141418796.1\|1662741_1665177_+\|TonB-dependent-receptor	gnl\|CDD\|379720	pfam14905, OMP_b-brl_3, Outer membrane protein beta-barrel family. This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	1.06309e-59
NZ_AP019739.1\|WP_141418803.1\|1683031_1685098_+\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_AP019739.1\|WP_141418799.1\|1673598_1674786_-\|sodium:proton-antiporter	gnl\|CDD\|366411	pfam00999, Na_H_Exchanger, Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.	0.000107081
NZ_AP019739.1\|WP_019129349.1\|1675916_1676111_+\|YtxH-domain-containing-protein	gnl\|CDD\|378938	pfam12732, YtxH, YtxH-like protein. This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterized.	7.5356e-06
NZ_AP019739.1\|WP_141418800.1\|1675329_1675818_-\|DUF1273-family-protein	gnl\|CDD\|377733	pfam06908, DUF1273, Protein of unknown function (DUF1273). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	4.42836e-20
NZ_AP019739.1\|WP_141418802.1\|1679277_1680156_-\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	7.9369e-75
NZ_AP019739.1\|WP_026074688.1\|1669938_1671171_+\|6-phosphofructokinase	gnl\|CDD\|223283	COG0205, PfkA, 6-phosphofructokinase [Carbohydrate transport and metabolism].	2.33398e-55

>NZ_AP019739.1|WP_141418799.1|1673598_1674786_-|sodium:proton-antiporter
MKKVLTFSLLLVLGLVASQLLPGLLGADYASFKMCSDTLLYVCLAFIMINVGREFEIEKGEWRSYVSDYFIAMATAAVPWIFITLYYMFVMLPSVYWGDAEAWKENLLLSRFAAPTSAGILFTMLAALHLKSSWMYRKIQVLAIFDDLDTILLMIPLQIAMIGLQWQMFVVVAIVTLLLVAGWRKLGHYDLRQDWKSILLYAVVVFALTQGLYALTALLFGESGGIHIEVLLPAFVLGMTMRHRHVDSAAEARASSFVSFLFMFLVGVSMPLFIGVQHAEALSGHHSVTGSQPMMSWGTIAVHVLIVSLLSNLGKLFPVFFYRDRKLSERLALSIGMFTRGEVGAGVIFIALGYNLGGPVLIVSVLTIVLNLILTGGFVLLVKRLALKAYGTQPS
>NZ_AP019739.1|WP_019129352.1|1672134_1673253_-|DEAD/DEAH-box-helicase
MNFQELNLPNALLRALRDKEYERPTPIQMQAIPAALEGRDILGTAQTGTGKTAAFALPVLANLLRRPPVGRGRPIRALILTPTRELALQIDESLGDYAKYTPLRTCVVFGGVNQRPQIDCLKRGVDVLTATPGRLLDLIGQGHISLKQIEFFVLDEADRMLDMGFIHDIRRLLPLLPGQRQTLLFSATMPKTIERLAADLLNDPVRVAVEPVASVVDTIEQRLCYVEKPEKKQALISALKENDGRSVLVFSRTKHGADRIARIVSKAGIGCDAIHGDKSQTARQRALSNFKAGKTRVIVATDIAARGIDIDQLEMVINYDLPDVAETYVHRIGRTGRAGHSGMALTFCASDERPMLADIQKLTGKKLRVIAG
>NZ_AP019739.1|WP_141418798.1|1671255_1672059_+|tetratricopeptide-repeat-protein
MNSDKRAEREQHRAWLRECIARCRAEVARYEKAVERRPNTYRPRLAEAQHTLGKFYWWRHTPASYRTAFRLFTQALRNYDSYRGRRDLTLNRLTLMSDLQQLSLRLDDDRAEEVLLGLLSAYESMAAAAPLVYGEDVASTFWQLGNLHADARRFGEAERMYLRALDKHAEFDGEDPHRYRPATAQCRRSLGRLYEEMHDDARAEEAYLASAAILRELCEDPFERCNHLRSLVRTLMLLADLCERRGACGEAARYRTEAEALEAERGA
>NZ_AP019739.1|WP_026074688.1|1669938_1671171_+|6-phosphofructokinase
MKEAIAILTGGGPAPGMNTVVGSVAKTFLAKGYRVIGLHYGYSGLFNPSPRYEDLTFTQADYIFNQGGSYLTMSRFKPTDKDFEENFNLNFFTENNVKLLVTVGGDDTASTANRIAKFLEAKHYPIANIHVPKTIDNDLPLPAGTPTFGYQSAKEGGTVIGRAVYNDARTSANWFVVAAMGRSAGHLAFGIGSACHYPMIVIPEMFNKTEITVEKIVNLVVSSIIKRKIMGIDYGVAMISEGVFHALSDEEIKKSGIHFSYDEHGHPELGKVSKAHIFNEMLENKLKELKIKVKSRPVEIGYEVRCQTPIAYDLVYCSELGMGVYKLFSEGKTGCMVYISQDGFVSPLYLKDLQDPATGKIPPRLVNIDSDKIQQVIDNLMNYITPADYEAAKAYVADPEVFDFKKILNW
>NZ_AP019739.1|WP_026074689.1|1669424_1669625_+|cold-shock-protein
MKGKVKWFDGKKGYGFITGEDGKEVFVHYSGIVKDGFKALNEKQEVEYELGEGSKGIQAINVKVVE
>NZ_AP019739.1|WP_019129356.1|1669019_1669265_-|hypothetical-protein
MNARIITALLALLGFGAACSGVKETAKSTDSRADSVRVQRPIRLMYGVPVREFQARPLADSARGEGRLPSAEAQPEDVPAK
>NZ_AP019739.1|WP_026074690.1|1667742_1668222_+|2-C-methyl-D-erythritol-2,4-cyclodiphosphate-synthase
MLFRIGHGYDVHALAEGLPLVLGGVGIEHDKGCVAHSDGDVVIHALCDALLGAAALGDIGLHFPDTSDDYKGIDSKLLLHRVAELLAQKGYRIGNVDCTIRMQRPKLRPHIDRMRRTLADVMGIGVDCVSVKATTTERLGFEGREEGVSVSAVALIYRE
>NZ_AP019739.1|WP_141418797.1|1666828_1667737_+|restriction-endonuclease
MIPDYQTLMRPLLECIQDGQEHLFKNVIEQLADRFELTREEREQLAPSGHRALFSGRVGWAKTYLKKAGLLEQRKRGILSITSLGIKALKSKKKIDVTYLTGYPNFVDFYAPSSRNDKTRENECAPAIDPEETIAHAYEQIHNKLSSELLDVVLMQDFAFFERLVVELLVKMGYGGSIQDAGQAIGRTGDEGIDGIIKEDKLGLDVVHIQAKKWNRNNTVGRPELQKFVGALAGQGSTKGIFITTSSFTKEAQSYKPQGVKLVKIDGEKLTQLMIEYGLGVTTAFSYEIKRIDRDYFNDLDD
>NZ_AP019739.1|WP_141413412.1|1665292_1666738_-|beta-Ala-His-dipeptidase
MTDLTKLAPCEVWTEFEAITRVPRPSKKEEKIRDYLVGWAKEHGLEYRCDATGNVVIRKPATTGYEGRPTVILQSHMDMVCEKNSDVAFDFEHDAIRTRIDDGWVRAEGTTLGADDGIGMAAALAMLASATVAHPALEALFTVDEETGLTGAFGLGEGMLTGKYLINLDSEDEGELFIGCAGGVDTVAKFSPMVTPAPDGFEYFRIDVKGLAGGHSGDDIEKGRANSNKLVARLLYELLPYGPVLNRFDGGNLRNAIPREAFAVFGVPAETAGDVCERCRAFAVEIVEEFKYTEPNLQMTLNKIEGVEWVLDPVTMQSLVGALVGLPNGVLAMSHAVEGLVETSSNLASVKFGAEGIVVTTSQRSSVESAKRYAAQTVEAVLRLSGAEVAHSDGYPGWSPDPDSYLLHVTEQCYERLFAVKPKVRAIHAGLECGLFLEKYPELDMVSFGPTLRGVHSPDERLEIATVQKFWDLLCAVVGSL
>NZ_AP019739.1|WP_141418796.1|1662741_1665177_+|TonB-dependent-receptor
MKKRTLLLLLSLLPLSMTAQQKFLLRGQVVDAANDSPVSFATTALLRDSTAVAAVAADAQGRFELSAEAAGDYRLQITMVGYNPETQPVTLRTAATDAGTIRLRQGVDIDQVTVTIQKPLVTADAEKTTYSVEDDPQAASSTLEEILRKVPQLTIDAEGNVKLNGQSDFKVLVNGRSSAMFKNFKDVIRSMPASQIKKIEVITEPSMKYDAEGAGGIINIITARKEFDGYNGSLNYNTGLDTRQQYGGASLSVQKGKFAASVQAFFFQMNRRNRPYTSESRRENFASEQQRYHTSESTGYGKGHNEYVTLNLSYQPDTLNLVTLEGSLWTGAWKNSSDTRIRMSDAAETPTVAYDTHDYDNYPYTGFQVGANYERRFRKPEHTLTVSDMVEIDPDKGYNLVTYDGVLNYPSSQLYKRHTSRSFTNTFQLDYYNPLAEHHYVEAGSKYIYRINKGYQNEIPWIDPVGFDPTNMTKYDDLRQRQQIFSLYFGYGLKFSKVSARAGVRMERTWNHADADNSREGIYDYGNRLLNFIPYLSFTYKPRDGHNLSLSYTERLRRPSISMLSTYLDDSDPYNTSQGNPDLEASTTHTLSLKYNYFSPKWSGTFTLSGHLSNDGISSWTSVDDQGVSHTTYSNNVRERTASARLSVNYSPSEKFSFALNGRGGYSHYRLPQEEISTEEFTFDQNLNMNIALWKAATVSLGEGYNSGSANLGRKSGDYFYSYATLSQKFFDKKLQISVSCYNPFTKYQTYSSTAQTPTYRSQSRSRNHSRQFSIGAYWRFGKQNVQVRKTRKSISNDDMMDGGNKQGGKQ
>NZ_AP019739.1|WP_141418800.1|1675329_1675818_-|DUF1273-family-protein
MDRSREHTAAFTGHRRYDGECDDALRAVVRELYGWGFRVFWSGMALGFDLAAAEAVLALRGELPGLRLCCAVPFPGQADRFPEADRLRYMRILDRADEVATLAPRYEPRCYLRRDEFMVERSAAVVAWFDGGKGGTRYTWDYARRCKAERINLWCDGQQELF
>NZ_AP019739.1|WP_019129349.1|1675916_1676111_+|YtxH-domain-containing-protein
MKGSCFFAMLGGMVLGSVITLLATPKSGAEVRGQIKDLVNREARKVRDKYHEVEGKVEEAAAKK
>NZ_AP019739.1|WP_019129348.1|1676120_1676432_+|hypothetical-protein
MYSDSTERSFAGALVFFLVMALSAYVLLVTALVFWLAELLGSLPLAAVLLGGFTLLIALLTYQLAVRDAIARLRERWEVVYEVMRTVHDGYRRVSGFLHRLLW
>NZ_AP019739.1|WP_141418801.1|1676507_1678238_-|acyl-CoA-dehydrogenase
MANFFLDNKDLQYHLEHPLMRKIVELKERGFAEKDTYDYAPQNFEDAMDSYRKVLAIAGEVCGDVIAPNAESVDHEGPKVVNDHVVYAEGTQRNLDAVVKAGLSGLTLPRKYDGLNFPLLCFVMTNEMVARADAGFENIWGLQDCAETLNEFASEELKQKYLPWVSAGATCAMDLTEPDAGSDLGAVMLKATWSEQKGTWLLNGVKRFITNGDGDVSLVLARTEEGTTDARGLSMLVYDKRDGGVKVRRIENKLGIKGSPTCELVFTNAPAQLVGDRKMGLIKYVMSLMNAARLGIGAQSVGLCEAAYREALKYANERAQFGKNIIRFAAISEMLSNMKAKTQGVRALLYETTRFVEIYKQYTHISHERPLEAEERQEMKYYNKLADGFTPLLKLFSSEYANQMAYDAIQIHGGSGFMKDYACERLYRDARIMNIYEGTSQLQVVAAINHVTKGTYLEQIKRYEEAGHIEAVQPLVERLVSLRAKFEEAVAHVEQIEKETCGFKELHARRLVEMAGYLAITHLLALQAGDREEYLLSAEIYGKLAASKIEEAYAYVMASTAADVELFKTIESETLC
>NZ_AP019739.1|WP_019129346.1|1678237_1679257_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MNNIFVYIELENGAVADVSLELLTKGRELADELGVKLEAVVLGHGVAGIEKELAKYGADTVWVADDEIFAPFRTLPHTAVLCGLIRQEKPQIALFGATPVGRDFAPRVSSALHSGLTADCTQLVIGDHTDPKTKTDYKNLLYQIRPAFGGNIIATIVNPDHRPQMATVREGVMRKEYAAKAGAGEVKPIDWRPMVQDTDLAVKIIDRQIEERKINIKGAGVIVAGGYGMGSKENFKLVHELAEVLGAEVGASRAAVDAGFAEHARQVGQTGVTVRPKLYIACGISGQIQHTAGMDQSSMIISINTDAEAPICKIADFAITGDVNEVIPKMIKYYKQNSK
>NZ_AP019739.1|WP_141418802.1|1679277_1680156_-|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MKKALKIVVLAKQVPDTRNVGKDAMTPEGTVNRAALPAIFNPEDLNALEMALALKDETEGSTVHILTMGPPRAADIIRDAMFRGADGGYLLTDRKFAGADTLATSYALSCALRKIRPDVIVAGRQAIDGDTAQVGPQVAEKLGWPQVTYAEELLEIKADSLVVKRRLEHGTEIVECPLPLVMTVNGSAPECRPQNAKRVMKYKFAQTKSEIAAAPDCMASAMASAKAYLQIVELAAADVDPDETQLGLVGSPTKVKKIENVVFQAKESKRLTAADADIESLMVELIASHTLG
>NZ_AP019739.1|WP_162829814.1|1680230_1680938_-|OmpA-family-protein
MEYSMRRISLLCVTCAAAMMVAGGCASMSGTLKGGLIGGGGGTAVGAGIGALAGGGKGAAIGAGVGLALGATAGALIGRKMEKQKAELAAIEGAEVETVTDTNGLDAIKVTFDTGILFPTNGTALNASAKAALDKFAISLLQNPDTDVTVFGHTDSTGTLAVNERISLERAQAVRNYLETKGIASNRFLKVEGKAYTEPVASNDTAEGRAANRRVEVYISAGQAMIRQAQEGTLQ
>NZ_AP019739.1|WP_019129343.1|1680963_1682229_-|adenylosuccinate-synthase
MKKVDVILGLQWGDEGKGKVVDVLTPHYQVVARFQGGPNAGHTLEFNGEKYVLRSIPSGIFQGDKVNVIGNGVVLDPILFKEEAEALARSGHDLTERLYISKKAHLILPTHRVLDAAFEAAKGSSKIGTTGKGIGPTYTDKISRNGVRVGDIFLDFKKIYEVAKARHENILESLGYNYDIDELERQWFEGIEYLKKFRIIDSEHEINRFLAEDKAILAEGAQGTLLDVDFGSYPFVTSSNTICAGACTGLGIGPNRIGEVYGIFKAYCTRVGSGPFPTELFDETGEALCRLGHEFGAVTGRKRRCGWLDMVALKYAIMVDGVTKLIMMKADVMNDFDTIKVAEAYEIDGRRVTEFPYDIQDDVKPVYREFKGWKTDLKQVRRYEDFPAEFKTYVEYIERETGVPVAIISVGPDRDETIVRQ
>NZ_AP019739.1|WP_141413674.1|1682566_1682884_-|hypothetical-protein
MANKKHLVASFHNLSPELQEEIKQKYPLGFTDAMIRVDKPNGDFFYAVPYDTDEISYLVKIDVKIDDLSEDEEEKEYYDDEIKGADDIQEESSQAEEATDDDVEI
>NZ_AP019739.1|WP_141418803.1|1683031_1685098_+|NAD-dependent-DNA-ligase-LigA
MGILERIRELRTQLNDHNRKYYVENAPEISDFEFDLLLRELQELEAAHPEYADPNSPTVRVGSDITSEFRSVRHHFPMLSLGNTYSLDELHEFIERVEKEVGETEFVCELKFDGTAISLTYDHGRLSQAVTRGDGTAGDDVTANVRTIRSVPLVLSGEGYPDLFEIRGEILMPYASFDRLNAEREAAGEPLFANPRNAAAGTLKQLSSAVVARRGLDCTLYQLAGDDLPYDSHWENLQKAREWGFKISNEMRICRSIAQVDEFIAHWDEARSRLPFPTDGVVVKVNRYADRRALGSTAKAPRWAVAYKFKAEQALTELLSVDFQVGRTGAVTPVANLAPVQLAGTTVKRATLHNAEQIAQLDIRLGDRVYVEKGGEIIPKITGVDFAQRKADSRPFEYITVCPVCGTPLVRYEGEAKYYCPNQNHCEPQILGRIIHFIRRKAMDIDGLGEETVELLYRNGLVHDAADLYDLRAGQITSLPRMGEKSAENIMESIRRSKLVPFPRVLFALGIRFVGETTAKYLASHFGSMDAVMRATREELVEAEEVGPKVADGILDYFADEGNRTLIERLRRAGLKFEAEAPRLRSDALTGKSFVISGKFSTHSRDELKELIELHGGRNLAAVSANVDYIVAGENMGPAKLKKAEKLGIPILTEKEFLALIADDEPAAATFAAAEPETPAQPTQGALF

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Crispr_ID: NZ_AP019739_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_13

1799539-1799657

Orphan

Consensus_repeat	Method
CCGCTTAGACAGGCGGCGCCTCGGCAAAATCGCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_13

>merge|NZ_AP019739|13|1799539-1799657|CRISPRCasFinder
CCGCTTAGACAGGCGGCGCCTCGGCAAAATCGCAAGCTTCGCTTGCTTTTGCGCTCGGCTTGCACAACTTTGCGGGATTGCATCCCGCTTAGACAGGCGGCGCCTCGGCAAAATGCAAA

>NZ_AP019739|13|12|1799539-1799657|CRISPRCasFinder
CCGCTTAGACAGGCGGCGCCTCGGCAAAATCGCAA	GCTTCGCTTGCTTTTGCGCTCGGCTTGCACAACTTTGCGGGATTGCATC
CCGCTTAGACAGGCGGCGCCTCGGCAAAATGCAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141418860.1\|1804567_1805725_-\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_AP019739.1\|WP_019129222.1\|1810960_1812124_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370579
NZ_AP019739.1\|WP_141419663.1\|1806654_1808316_-\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_AP019739.1\|WP_019129238.1\|1797569_1798082_-\|DUF456-domain-containing-protein	unknown	unknown	gnl\|CDD\|377293
NZ_AP019739.1\|WP_141419660.1\|1793895_1794456_-\|DUF4251-domain-containing-protein	unknown	unknown	gnl\|CDD\|372897
NZ_AP019739.1\|WP_026074669.1\|1805762_1806611_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
NZ_AP019739.1\|WP_141411777.1\|1789690_1789888_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_162851481.1\|1802823_1803441_+\|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019129242.1\|1792280_1793552_+\|serine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235461
NZ_AP019739.1\|WP_141419661.1\|1799745_1801743_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|367566
NZ_AP019739.1\|WP_019129241.1\|1793595_1793763_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|274983
NZ_AP019739.1\|WP_026074672.1\|1798134_1798488_-\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NZ_AP019739.1\|WP_019129243.1\|1791632_1791773_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019129230.1\|1803511_1804552_-\|glycerophosphodiester-phosphodiesterase-family-protein	unknown	unknown	gnl\|CDD\|176509
NZ_AP019739.1\|WP_141411780.1\|1798501_1799338_-\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|376824
NZ_AP019739.1\|WP_019129226.1\|1808349_1808610_-\|HPr-family-phosphocarrier-protein	unknown	unknown	gnl\|CDD\|224836
NZ_AP019739.1\|WP_141418861.1\|1808613_1810461_-\|PTS-mannitol-transporter-subunit-IICBA	unknown	unknown	gnl\|CDD\|237905
NZ_AP019739.1\|WP_034779249.1\|1802139_1802796_+\|DUF4136-domain-containing-protein	unknown	unknown	gnl\|CDD\|379281
NZ_AP019739.1\|WP_141418859.1\|1789941_1791582_-\|fimbrillin-family-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141411779.1\|1794644_1797548_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141418860.1\|1804567_1805725_-\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_AP019739.1\|WP_019129222.1\|1810960_1812124_-\|hypothetical-protein	gnl\|CDD\|370579	pfam09603, Fib_succ_major, Fibrobacter succinogenes major domain (Fib_succ_major). This domain of about 175 to 200 amino acids is found, in from one to five copies, in over 50 proteins in Fibrobacter succinogenes S85, an obligate anaerobe of the rumen. Many members of this family have an apparent lipoprotein signal sequence. Conserved cysteine residues, suggestive of disulfide bond formation, are also consistent with an extracytoplasmic location for this domain. This domain can also be found in small numbers of proteins in Chlorobium tepidum and Bacteroides thetaiotaomicron.	3.77259e-34
NZ_AP019739.1\|WP_141419663.1\|1806654_1808316_-\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
NZ_AP019739.1\|WP_019129238.1\|1797569_1798082_-\|DUF456-domain-containing-protein	gnl\|CDD\|377293	pfam04306, DUF456, Protein of unknown function (DUF456). This family is a putative membrane protein that contains glycine zipper motifs.	5.48336e-21
NZ_AP019739.1\|WP_141419660.1\|1793895_1794456_-\|DUF4251-domain-containing-protein	gnl\|CDD\|372897	pfam14059, DUF4251, Domain of unknown function (DUF4251). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 164 and 196 amino acids in length.	3.59493e-33
NZ_AP019739.1\|WP_026074669.1\|1805762_1806611_-\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	5.54419e-25
NZ_AP019739.1\|WP_141411780.1\|1798501_1799338_-\|pantoate--beta-alanine-ligase	gnl\|CDD\|376824	pfam02569, Pantoate_ligase, Pantoate-beta-alanine ligase. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (EC:6.3.2.1) catalyzes the formation of pantothenate from pantoate and alanine.	4.23974e-133
NZ_AP019739.1\|WP_019129242.1\|1792280_1793552_+\|serine--tRNA-ligase	gnl\|CDD\|235461	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional.	0
NZ_AP019739.1\|WP_141419661.1\|1799745_1801743_+\|dihydrofolate-reductase	gnl\|CDD\|367566	pfam03571, Peptidase_M49, Peptidase family M49.	4.62018e-37
NZ_AP019739.1\|WP_019129241.1\|1793595_1793763_+\|4Fe-4S-binding-protein	gnl\|CDD\|274983	TIGR04105, hypothetical_protein, [FeFe] hydrogenase, group B1/B3. See for descriptions of different groups.	5.7891e-09
NZ_AP019739.1\|WP_026074672.1\|1798134_1798488_-\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	2.70849e-74
NZ_AP019739.1\|WP_019129230.1\|1803511_1804552_-\|glycerophosphodiester-phosphodiesterase-family-protein	gnl\|CDD\|176509	cd08566, GDPD_AtGDE_like, Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase (AtGDE, EC 3.1.4.46) and its uncharacterized eukaryotic homolgoues. Members in this family shows high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. AtGDE exists as a hexamer that is a trimer of dimers, which is unique among current known GDPD family members. However, it remains unclear if the hexamer plays a physiological role in AtGDE enzymatic function.	1.56567e-48
NZ_AP019739.1\|WP_019129226.1\|1808349_1808610_-\|HPr-family-phosphocarrier-protein	gnl\|CDD\|224836	COG1925, FruB, Phosphotransferase system, HPr-related proteins [Carbohydrate transport and metabolism].	1.89266e-21
NZ_AP019739.1\|WP_034779249.1\|1802139_1802796_+\|DUF4136-domain-containing-protein	gnl\|CDD\|379281	pfam13590, DUF4136, Domain of unknown function (DUF4136). This domain is found in bacterial lipoproteins. The function is not known.	2.10217e-27
NZ_AP019739.1\|WP_141418861.1\|1808613_1810461_-\|PTS-mannitol-transporter-subunit-IICBA	gnl\|CDD\|237905	PRK15083, PRK15083, PTS system mannitol-specific transporter subunit IICBA; Provisional.	0
NZ_AP019739.1\|WP_141411779.1\|1794644_1797548_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	7.67119e-51

>NZ_AP019739.1|WP_141411780.1|1798501_1799338_-|pantoate--beta-alanine-ligase
MKTVTSVKALREVLSAVDSTGIGLVPTMGALHAGHRSLVERARRENATVVVSVFVNPTQFNDKNDLRNYPRTPEADCALLEAAGADVVFMPSVEEMYPVPDLRQYDFGRIDKVMEGATRPGHFNGVAQVVSKLFAMVQPARAYFGEKDFQQIAVVKSMVAQSGFPLEIVECGIVRGDDGLALSSRNALLDAAHRAAAPDICRALRLGAERAAGMTPAELADFVTRETERSGLLEVIYFQSVDALTMQQVAAWDESERIQGCIAVQAGAVRLIDNIRIK
>NZ_AP019739.1|WP_026074672.1|1798134_1798488_-|aspartate-1-decarboxylase
MQIEVLKSKIHRVTITEANLNYVGSITIDEELMEAANLIEGERVQIWNVTNGERLDTYVIRGRRGSGAICLNGAAARKAQVGDVLIIASYARMEFEEAKTFRPWVVFPDTATNRLVE
>NZ_AP019739.1|WP_019129238.1|1797569_1798082_-|DUF456-domain-containing-protein
MDVFLSITAFLCCLVGIVGCIVPVLPGPVLSYAGLFCAYACSYSTLTPAEMWLWAGLTAAVTAADYFLPGYMAKLFGGTRAGMVGATVGMIAGLFVGGLIGIVVGPFVGAVAGELLNDRERIGQALVVGVGSFLSFLVGTGIKLVAAVGMLTFVVADTWPALRAWFATVF
>NZ_AP019739.1|WP_141411779.1|1794644_1797548_-|insulinase-family-protein
MKRVFLLVAAAVLSLVVTSCSKYRYEEVADDPLHSRIYTLDNGLKVYMTVNGEAPRIQTYIAVRVGSKNDPLETTGLAHYFEHLMFKGTKSFGTQDYEAERPMLDEIERLFEVYRTTTDADERRAIYARIDSVSQEASKLAIPNEYDKLMSAIGAAGTNAFTSYDMTVYTEEIPSNQIDNWAKIQSDRFANAVIRGFHTELETVYEEYNMSLTSDSRKMLDSLMVALYPHHPYGMHTVLGTQEDLKNPSITNIKNYYKTYYVPNNMAICLSGDFDPDRMIATIDKYFGGLKPNPELPEWSFTPEPAMTAPVEKTVLGQEAEMIYLGWRTGGASSEDADMIQLVSSLLSNGKCGLLDVDIQQQQKMLGVGAEGLQLADYGMMVAIGYPKPGQTLEEARDMLLDEIGKLRAGDFDEELLASTIANYKRGEMQALEENGNRAMAYVDAFINGVDWKRSVEELDRLSKVTKADVVAWANEKLDPEVYAAVYKRQGVDPNIHKIDKPQITPIATNRDKSSEFLAAIQAAEVEAVQPVFVDYASDLSVGKMKQDIEVLYKQNTTNGLFSLYYVYDFGTTTDPAFGIASDYFDLLGTDTQSLQEIQREFYDLACSFGIHAGGERIYVTISGLAENMDKAVKLAEEYMQNVEGDDAVLAQLKANAMKARNDAKLNQNANFRALQQYTFYGPEAIRARTLTDEQLMALTSDELLARIRSLSDYEHYVMYYGPETEAKLIAALDAIHRTSQELKPVRKVRFPLLTVDKSEVNVAQYDAKQIYYLQYSNRGEKFSTDNDPGETLFNSYFGGGMNAVVFQEMREARSLAYTAFATFTEMRDKDDPYIFYAFIATQNDKMRQAVEAFDEIIENMPESEKAFELAKQGILANLSTQRTVRDNVLWSFVSAREMGVGVDRNKAVYDAVQGMTLADVKAFHDKWVKGRKYTYSILGDRNDIDMDYLRTLGPVHEVSQRELFGY
>NZ_AP019739.1|WP_141419660.1|1793895_1794456_-|DUF4251-domain-containing-protein
MTLCLLAGVVNPARPQARRTRTQAEQTRSADRERAKREQAVADSLAHLKALRSLDRLDFALEADRLTLRRGRVVFVSSDTNFVTLSGDMTTVQVAPFMGGGPNGIGGITLEGHASNIRVRTDKRGNTTFSMNVFGRGISATLSIRLPAGSNRASVSIDPNFSSDRIQLTGVLVPLDESRVFKGSAL
>NZ_AP019739.1|WP_019129241.1|1793595_1793763_+|4Fe-4S-binding-protein
MAYKITDACVACGTCIGECPVEAISAGDIYVIDADKCIDCGTCAGVCPSEAIIPE
>NZ_AP019739.1|WP_019129242.1|1792280_1793552_+|serine--tRNA-ligase
MLTLKQLRDDKEAAVRRLAKKGVDARPVIDRIEQLDDRRKAIQQELDNCLSQQNQAAKMIGALMGQGKRDEAEAKKAEVAALKEKSVKLSAEMKQTADALQAEIVLLPNFPAEIVPEGTSAEDNLVVKLVENYTPLPAEALPHWELAKKYDIIDFDLGVKLTGAGFPVYKGKGARLQRALINYFLDYNTRAGYQEVEPPVMVNEASGFGTGQLPDKEGQMYHATVDNFYLVPTAEVPVTNIFRDVILDEKDFPVKMTAYTPCFRREAGSYGKDVRGLNRLHQFDKVEIVRLSLPDDSYEALDDMVAHVEGLVKSLGLPYRILRLCGGDMSFTSALTYDFEVYSEAQKRWLEVSSVSNFESFQANRLKLRYRDANKKIHLAHTLNGSSLALPRIVAALLENNQTPEGIRIPEVLIPYTGFDIIK
>NZ_AP019739.1|WP_019129243.1|1791632_1791773_-|hypothetical-protein
MNYYQSEKEAYVVPRAIVFDVKVEEGFASSGEGEITPGEEDSEWGN
>NZ_AP019739.1|WP_141418859.1|1789941_1791582_-|fimbrillin-family-protein
MKRSFFALLAAAVSGLASCQQDGTQDDAALPMNVYSFDATTEGTRVSLDHTALTYTWDGSEQVMVWYAPAASAPDYDYTLIGDPFVAESAGAKTAFSLRTEYDLSEMGYDDQNYVLMYPWPYAGTSGVSGDEVTYTIGTREGDGYVQKDVFEGIYNLMRAETTGSSLLVGRPPVTFEHLLTSLRFYVKESAEPAFDDIRITDMEILFPENVIGETKVNFRKGYVASASSRKVIVDLDAPLTPQKSYKDESGEANDDQYALVVVKPFTLKANTDGNANDRILVTLRGTGTDIHTGEAERITQTLVLTSDSDMEFEAGHFRAVSLQLENDWTPVDVQLTEAFAPAGDYAHGAGIMFDKRGECFGFHASIKDAADKERMIVLDNTSNRWSLGTSWLYAQSAFYMPSSTVLKGYTQGDIAVTFDAHVVFSGKDKNPCPIIIGFNHCSTRTNGDTGDGGFVALASVDAEPALMTAKEAKENGGYPEDAAYWRSYEVVIPAETIAGIDQFMEPNKDGSAAHMGFKLDGQVGASSSKGRMVYIKNICFSYENK
>NZ_AP019739.1|WP_141411777.1|1789690_1789888_-|hypothetical-protein
MMKPILNDGCDSLPCRPLDCYVPPCLTNLAVAAERGFAASYFDDEDEFVSDGFDDGGAPDLSDWD
>NZ_AP019739.1|WP_141419661.1|1799745_1801743_+|dihydrofolate-reductase
MTTSVACLGSCTNPAASDAQQPWIVDRFDDIKVIRYEVPGFERLPLEQKELIYYLAEAAKCGRDILFDQNCAANLPIRRTLETLYLNYKGDRTSDEWKALEKYLKKVWFANGIHHHYSNDKFRPEFSESFFREAAASVGMDRFPADFDFLCKVIFDPAIYPTRLNQAAGADMLWTSASNYYSNVRQHEAEQFYTAMAAADAGDPCPVSYGLNSQLVKEEKTGRLYERTWKVGGMYSPAIERIVYWLEKARDVAAEPQKQTLAALIDYYRTGDLKQFDRYNILWLQDTVSNVDFVNGFIETYGDPLGYKASWEANVNFVDSAACRRTRIISENAQWFEDHSPVDPAYKKKVVKGVSAKVITVAMLGGDCYPATPIGINLPNADWIRKEHGSKSVTIDNITYAYDRAAHGNGFEEEFMLRPEDRERIDKYGKIGDDLHTDLHECLGHGSGQLAPGVKGDELKSYGSTLEETRADLFGLYYLGDPKLVELGLVPSFDVAKAQYASYILNGMMTQLARIEPGKNVEESHMRNRKLIAEWCYEQGKADNVIEWRTEQGKTYVVVNDFEKLRELFGRMLREIQRIKSEGDYEAGKALVEQYAVKVDPKLHREVLDRYEALHIEPYGGFVNPEYELVERDGRIVDVKIAYPANYVEQMLGYSRDYSFLPDRN
>NZ_AP019739.1|WP_034779249.1|1802139_1802796_+|DUF4136-domain-containing-protein
MTTKNLLTSLLVLLAVAVVSCQKEPSTSGLHEDYLVYTDYDQQADFSDVETFYLPDSILVIGNADKTEYWKDADAQEIIGTVADLMESRNFVRTDDKETAQTGLQISYVERVTYFVGYDYPYWWWYYPYYWAPGYWGDWLGWHYPYQVYYGYTAGSMLIEMVDLTADRQSNRKLPVIWDSFIGGLLTSSHKVNMQRTLDAVNQAFMQSPYLETNSVNR
>NZ_AP019739.1|WP_162851481.1|1802823_1803441_+|outer-membrane-beta-barrel-protein
MFSRKALLLAVAAVTFALPGRAQLIQNTYLNVDWQVTVPLGSAFADKASGWGMNFEGGYFVTPEITVGAFISYQTNIESISRQTLQLGSGAAMTTAQKHTLFELPFGVVGRYNFLKGSVFQPYAGLRIGADYAEMSSYYYTIQQYQDTWGVYLSPEIGVSIFPSPAQRFGFHVALFYSYASNNDDLLIYTMNNINRFGVRVGISF
>NZ_AP019739.1|WP_019129230.1|1803511_1804552_-|glycerophosphodiester-phosphodiesterase-family-protein
MKRPFIAVTALTLATAISFTSVAEERPASEKRLHTVQINSLEDLKAYFRYDPERDIIVSGHRGGMMPGYPENCIESCEKTLSMMPTFFEIDFSFTKDSVMVLMHDLTIDRTTNGKGRVADYTYEELQGFRLVDRDGKLTPYRIPRLKDMLEWGKDKVVFNFDNKYINTKGVSDEVRKASLDYYIRQLRPGGDWSMYHNIMLSVRSLDEAMYYWNAGIRNVMFCCEISSREMFDAYDACPIPWDYIMAYIRLSVDPRLQEVYDLLHERGVSTMTSITGSSDKVKNPRDRRVCYLRDLVSEPDLIETDYPSEFVDLPRSRAEIHALQDRAIEGNRSVKADKAKKNRRK
>NZ_AP019739.1|WP_141418860.1|1804567_1805725_-|mannitol-1-phosphate-5-dehydrogenase
MKRAIQFGAGNIGRGFIGAVLSEAGYHVVFADVNMEVIDRINKDGAYTVHIMDVESRDVRISNISGVDSGGGEIVDEIVRAEIITTAVGLRILPFIAPAIAKGIAARRAAGVGEPLNVIACENGIRATSQLREEVYKHLSAEEAAWCDAHVGFADCSVDRIVPPVRSENPIDVVVENFYEWNVEEKSFVGGAPHIEGMNLADNLLAYIERKLFTLNTGHAITAYLGRMKGLATIDESIADPAIFAIVKEAMQQSGQALVEKFGFDRDAHFKYIDKIIGRFKNPYLKDDVARVGREPLRKLSSTDRLVKPMMTAREYGLPCDKLLLGIGAALHYNNPEDPQSVKMQELIAAKGLRQAVSEITSIPATDPVIEEIAAATAEVEKRIR
>NZ_AP019739.1|WP_026074669.1|1805762_1806611_-|alpha/beta-hydrolase
MKKLFLTCFCCASAVLGARAQDEHIVIWDNASAPTSSGLFGPTVIEKEVFVANNNVAELFVYKAEEPSGRAVVVCPGGGYHNLAIGYEGHDMARWLADHGTTAAVLKYRMPNGHCEVPRNDAEQALRIMREHAAEWGYDASRVGIVGSSAGGHLAASTGTISDEKPAFMILFYPVITAEEGKLHKNSFKYLLGKDYSPEEARNYSLEKRVSALTPPTLLLLSDDDRIVPPVNSLLFYEALKRNGVKASIHVFPTGDHGWGIKPEFKYIEQWQRYALDWLEQF
>NZ_AP019739.1|WP_141419663.1|1806654_1808316_-|phosphoenolpyruvate--protein-phosphotransferase
MADAVAIGRVWRYRAGAYAPSGRVVPSGERPAEQSRFDAAVAAAEGELEKLAAANEIFAAHLELAADPMLMENVAEKIAEGMTAADAVHAASGELAALFAQIDDEYLRARADDVRDVCRRILRQLVPSETDPFAAIPDGSILAADELAPSDTARIDFSRVRGVVTRRGSATSHLAILARNRNLPAVVGLGDDFDRLDDGTIVVLDGPAGELLIAPDEHTAAEYRRRMEEAEARSAAADAYASQPVTTRDGRALAVLANAGSVDEVERAIRSGADGIGLFRSEFLYMQRQDGFPDEQVQTAAYARAAELCGGRPLVIRTLDIGGDKSLPYYRFPEEENPFLGWRAIRVSLELRDMFRTQLRAILRASARGGVRVMFPMIVSLAELRDALALLEECKEELRRQEVPFDDRIPVGVMIETPAAVFMADELAAEVDFFSIGTNDLTQYVLAVDRGNRRIAAMYDTLHPAVVRAMRLTVDAAHRHGCEVGICGEFAGCAAHAELLVGLGFDELSVAPPSVPAVKERIRGLETPQAELTARRAVEAATASEVHELIGVG
>NZ_AP019739.1|WP_019129226.1|1808349_1808610_-|HPr-family-phosphocarrier-protein
MVSKTVTIEAPNGMHARPVSALVALVKASGQQVTLRTPAKSVSGASMIGILSLGLKKGSEVEVAVEGDNEQAVLDEVVAAIEAITD
>NZ_AP019739.1|WP_141418861.1|1808613_1810461_-|PTS-mannitol-transporter-subunit-IICBA
MKERIQRFGKSLSSMVMPNIGAFIAWGFITALFIPTGWWPNASLGQLVEPMLRYLLPLLIAMTAGRHVAGDRGGVIAAVAVMGVILGSDIPMFIGAMAIGPFAGWVIRSFDRWAEGRIPAGFEMLVNNFSVGILGIVCALIGFYAVGPVVSALTVFLSAGVSLMIEHGLLPLVAVFIEPAKVLFLNNAINHGIFSPIGIEQARQTGQSIMFLLETNPGPGLGVLLAYWAFARGAARSSAPGAIVIQFFGGIHEIYFPYVLMRPAIIVAPIVGSAAAILFYSLTGTGLTAVASPGSIIAVAAMAPKGETLLVLAGVVVAAAVSFFVAAPIVKRAHLEEVKPVQKPNGTVIGGTSRAPRALEGPIRTVVFACDAGMGSSAMGATRFRKRIEPLGSGVRVTNSSVDTIPEGTDVVVCQSQLSQRAGKAAPASEVIVIGNFLSDPALDGLYGRIEGQTRASEAPQSEEVPAAATPAAPASEMLTLQGIRTGLAPVGKEEAIRAAGALLAACGYVDGEYAEAMVARERVATTYLGMGIAIPHGTAEAKSRIRRSGIVVMQYPEGVDFGEERAQLVIGIAGAGDEHIEILARVTSALEDEEVLRRLKTTDDPRYILEKLAI
>NZ_AP019739.1|WP_019129222.1|1810960_1812124_-|hypothetical-protein
MKKYLFMLLWTACAVACSDSDPAPQPDDEGPTPPPDKEQQVVCGIEKPEEGASVNLAEKLTIAGTGVATVGEIEKVVLKVGGIVVPEVTDVPFEIEYTFPAEQAEGELKLELSVEGDAGATASTEVTVTTYRKEGPAAPVEGTMTDARDGNVYKTVKLADQVWMAENLRYLPEQHDDVSDTEPRYYIWSDYDKDTQLGAEALKVYGAFYNWKAALQGEEPQTSADQAPVRGVCPEGWHIPSQAEWQQLAQYVLDADMAAVGSNGEVDETAIAKALAMDYPDDELMWNLPSMIEGDPQPTWPGIDKSKNNATKFSGIPIGFRSYSFNPADGGVQWDHASYSAGWWSSTQGVMGEGYCAVVRMWSDNQRFATDSNFIGGVGLTVRCLQD

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Crispr_ID: NZ_AP019739_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_14

1952034-1952131

Orphan

Consensus_repeat	Method
CAAAGATACGAAAAGTCGAGTGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_14

>merge|NZ_AP019739|14|1952034-1952131|CRISPRCasFinder
CAAAGATACGAAAAGTCGAGTGCAGAAGCAAGCGTCAGCTTGATTGTGCCGAGACGGAGTATCTAAGACGAAGTCAAAGATACGAAAAGTCGAGCGCA

>NZ_AP019739|14|13|1952034-1952131|CRISPRCasFinder
CAAAGATACGAAAAGTCGAGTGCA	GAAGCAAGCGTCAGCTTGATTGTGCCGAGACGGAGTATCTAAGACGAAGT
CAAAGATACGAAAAGTCGAGCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141411909.1\|1947864_1948383_+\|prolyl-tRNA-synthetase-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|239827
NZ_AP019739.1\|WP_141419667.1\|1942940_1943801_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_AP019739.1\|WP_141418913.1\|1967757_1969896_-\|DUF349-domain-containing-protein	unknown	unknown	gnl\|CDD\|377186
NZ_AP019739.1\|WP_141411906.1\|1944128_1946048_+\|RecQ-family-ATP-dependent-DNA-helicase	unknown	unknown	gnl\|CDD\|223588
NZ_AP019739.1\|WP_141418911.1\|1962368_1963979_+\|alpha-galactosidase	unknown	unknown	gnl\|CDD\|269893
NZ_AP019739.1\|WP_141418910.1\|1960826_1962170_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227779
NZ_AP019739.1\|WP_141418912.1\|1964064_1966011_-\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|234942
NZ_AP019739.1\|WP_141418901.1\|1941995_1942706_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|225130
NZ_AP019739.1\|WP_141418906.1\|1950891_1952004_-\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
NZ_AP019739.1\|WP_162502187.1\|1959426_1960743_+\|DUF1735-domain-containing-protein	unknown	unknown	gnl\|CDD\|378016
NZ_AP019739.1\|WP_141418907.1\|1953121_1954087_+\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP019739.1\|WP_141419668.1\|1954327_1957507_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_141418900.1\|1939731_1941513_-\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NZ_AP019739.1\|WP_141418902.1\|1946073_1946676_+\|3'-5'-exonuclease-domain-containing-protein-2	unknown	unknown	gnl\|CDD\|176653
NZ_AP019739.1\|WP_141418908.1\|1957523_1959404_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NZ_AP019739.1\|WP_141418904.1\|1948468_1949644_-\|DUF1343-domain-containing-protein	unknown	unknown	gnl\|CDD\|377768
NZ_AP019739.1\|WP_019131071.1\|1966035_1967655_-\|CTP-synthase	unknown	unknown	gnl\|CDD\|235437
NZ_AP019739.1\|WP_141418903.1\|1946672_1947875_+\|methyltransferase	unknown	unknown	gnl\|CDD\|224017
NZ_AP019739.1\|WP_019131063.1\|1952414_1953020_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_AP019739.1\|WP_141418905.1\|1949654_1950845_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|223503

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141411909.1\|1947864_1948383_+\|prolyl-tRNA-synthetase-associated-domain-containing-protein	gnl\|CDD\|239827	cd04335, PrdX_deacylase, This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the YbaK and ProX proteins, and the prolyl-tRNA synthetase-editing domain (ProRS-INS), specifically hydrolyzes Ala-tRNA(Pro). In this CD, many of the eukaryotic editing domains are N-terminal and cis-acting, expressed from a multidomain ProRS, however, similar to the bacterial PrdX, the mammalian, amphibian, and echinoderm PrdX-like proteins are trans-acting, single-domain proteins.	2.98358e-50
NZ_AP019739.1\|WP_141419667.1\|1942940_1943801_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	4.42086e-08
NZ_AP019739.1\|WP_141418913.1\|1967757_1969896_-\|DUF349-domain-containing-protein	gnl\|CDD\|377186	pfam03993, DUF349, Domain of Unknown Function (DUF349). This domain is found singly or as up to five tandem repeats in a small set of bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.	2.14975e-15
NZ_AP019739.1\|WP_141411906.1\|1944128_1946048_+\|RecQ-family-ATP-dependent-DNA-helicase	gnl\|CDD\|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	2.96658e-157
NZ_AP019739.1\|WP_141418911.1\|1962368_1963979_+\|alpha-galactosidase	gnl\|CDD\|269893	cd14792, GH27, glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.	1.12334e-114
NZ_AP019739.1\|WP_141418910.1\|1960826_1962170_+\|hypothetical-protein	gnl\|CDD\|227779	COG5492, COG5492, Bacterial surface proteins containing Ig-like domains [Cell motility and secretion].	0.00255854
NZ_AP019739.1\|WP_141418912.1\|1964064_1966011_-\|membrane-protein-insertase-YidC	gnl\|CDD\|234942	PRK01318, PRK01318, membrane protein insertase; Provisional.	4.29982e-123
NZ_AP019739.1\|WP_141418901.1\|1941995_1942706_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	1.37701e-25
NZ_AP019739.1\|WP_141418906.1\|1950891_1952004_-\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	1.08043e-160
NZ_AP019739.1\|WP_162502187.1\|1959426_1960743_+\|DUF1735-domain-containing-protein	gnl\|CDD\|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	7.04533e-11
NZ_AP019739.1\|WP_141418907.1\|1953121_1954087_+\|DUF4974-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	3.32442e-18
NZ_AP019739.1\|WP_141419668.1\|1954327_1957507_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_141418900.1\|1939731_1941513_-\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	0.000778218
NZ_AP019739.1\|WP_141418902.1\|1946073_1946676_+\|3'-5'-exonuclease-domain-containing-protein-2	gnl\|CDD\|176653	cd06141, WRN_exo, DEDDy 3'-5' exonuclease domain of WRN and similar proteins. WRN is a unique RecQ DNA helicase exhibiting an exonuclease activity. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Mutations in the WRN gene cause Werner syndrome, an autosomal recessive disorder associated with premature aging and increased susceptibility to cancer and type II diabetes. WRN interacts with key proteins involved in DNA replication, recombination, and repair. It is believed to maintain genomic stability and life span by participating in DNA processes. WRN is stimulated by Ku70/80, an important regulator of genomic stability.	3.76697e-56
NZ_AP019739.1\|WP_141418908.1\|1957523_1959404_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	1.10492e-49
NZ_AP019739.1\|WP_141418904.1\|1948468_1949644_-\|DUF1343-domain-containing-protein	gnl\|CDD\|377768	pfam07075, DUF1343, Protein of unknown function (DUF1343). This family consists of several hypothetical bacterial proteins of around 400 residues in length. The function of this family is unknown.	1.42579e-165
NZ_AP019739.1\|WP_019131071.1\|1966035_1967655_-\|CTP-synthase	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NZ_AP019739.1\|WP_141418903.1\|1946672_1947875_+\|methyltransferase	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	9.68796e-129
NZ_AP019739.1\|WP_019131063.1\|1952414_1953020_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	6.71483e-53
NZ_AP019739.1\|WP_141418905.1\|1949654_1950845_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|223503	COG0426, FpaA, Uncharacterized flavoproteins [Energy production and conversion].	6.16426e-119

>NZ_AP019739.1|WP_141418906.1|1950891_1952004_-|peptide-chain-release-factor-2
MVLAEQIKEAASRRDTLEKCLDIERKRMDLQNEEEKTQDPDFWDDAARAQEQLRRVASIKSWITDYDTIRKEVEDLELMPDFLKEGVISEEEMDAHYAQTIAHIEALELRNMLRRDEDKMGAILDINAGAGGTEALDWASMLLRMYTRWCEAHGYKVKTLDYQAGDEVGVKSCTLEIEGDYAYGYLKSENGVHRMVRLSPFNANNKRQTTFASVFVSPAVDDSIEVVINPSDIEWDTFRSSGAGGQNVNKVETAVRLRYHGKDPDTGEPVEFLIENMETRSQLMNRENAMRILRSKLYQRELDKRMATQQALEAGKKRIEWGSQIRSYVFDDRRVKDHRTGCQTSDVDAVMDGEIDAFIKAYLMQFGAEA
>NZ_AP019739.1|WP_141418905.1|1949654_1950845_-|MBL-fold-metallo-hydrolase
MKDLTKLTDRIFYVGVNDRTKHLFEGLWPLPLGVSYNAYLVCGERTALVDTVDACFTGRLLANVRERLGDRPLDYLVINHMEPDHSASIAAVRQAYPAVRIVGNAKTLQMIEGYYGIACGTVEVKEGDVLDLGGLTLAFCMIPMVHWPETMATWCAEERTIFSGDAFGTFGALNGGVTDEQLDVEPFWEEMRRYYACIVGKYGQPVQRALAKVAPLDIAMICSTHGPVWRREIARVVELYDKVSRYEGEPGAVIAYGSMYGNTEQMAETVARGLAAAGVRPIVVYNLSTADVSQVLRDIFRYDTLVVGSPTYNGQLYPPVDALLRKIAERCIPHRRFACFGSFTWAGAAVRRMTEFAEGMKWPVVGAPVELKQGYSTAVEPACRTLVDALVEDMKR
>NZ_AP019739.1|WP_141418904.1|1948468_1949644_-|DUF1343-domain-containing-protein
MRKLLLFSLLCMLLPVAAAAAPEGACDGVTVGAADTAAYFPLLRGRRVAVLANQTSRVGDEHLVDLLHRSGVRLTAIFSPEHGFRGTADAGEHVASSVDERTGVPIRSLYDGRTRRPSDEAMRSFDVLLVDMQDVGLRFYTYYISMLRMMDACADFGRAVVVLDRPNPNGSYIDGPVLDMKYKSGVGALPIPVVHGLTMGEIARMAVGEGWAKPCDLTVVPCRRYTHATRYELPVAPSPNLPTQRSIYLYPSICLFEGTVVSLGRGTDRPFECYGHPDMPADRYGFVFTPRPTAGAKHPPLEGRLCRGVDLSEKPCEEILAEGLTLDYVIDAYRALGLGEAFFTPMFEKLIGVGWVREMILDGRSAAEIRARWRPDVERFAKMREKYLIYE
>NZ_AP019739.1|WP_141411909.1|1947864_1948383_+|prolyl-tRNA-synthetase-associated-domain-containing-protein
MWNKPSDSERIDAVTAWLDAADIAYDLYFHPASPTIELAKRHWRDDGSKHCKNLFFRNHKGNRHYLVCFDCDRTLSIHDLEARLHQGKLSFASPERMMRYLGLEPGSVSPFGLINDAEHHVHLFLDRNLLYCPSLSFHPNDCRATVVIARTEFERYLARVGNSYEYLDLYEE
>NZ_AP019739.1|WP_141418903.1|1946672_1947875_+|methyltransferase
MTTHPRIFLRRGKEESLLRRHPWIFSGAIGRVECPSDTIAEGEIVDVHTAAGDFIARGHYQIGSIAVRVLTFAQEPIDAAWWRARIRSACEVRRTLGLIGNAATTCYRLVHGEGDSLPGLVIDIYGTTAVVQCHSVGMYRSRMQIAEALREVYGERLAAVYDKSSQTVPYKAGLNAVDGYLMGKVATPTQEVSENGHRFLVNWEEGQKTGFFLDQRCNRELVERYAAGRTVLNTFCYTGGFSVYAAAGGAKEVCSVDASERAVQLADENMRLNFGDSFPHTTLACDAVEYLKQIGDRYDLIILDPPAFAKHHKVLGNAMQGYKRLNARALSQIRPGGILFTFSCSQAVTKELFRTTVFSAAAIAGRNVRILHQLAQPADHPINIYHPEGEYLKGLVLYVE
>NZ_AP019739.1|WP_141418902.1|1946073_1946676_+|3'-5'-exonuclease-domain-containing-protein-2
MEKRPFQQHISNEDTAKLPAVLFEGPIVIVDDEKQVEAACRDLASSPVLGFDTETRPSFKAGVTYRVALLQLSTPRRCYLFRLNRMRIEKQLVKLLENKAILKIGADVAGDIRSLLALRRFRPGGFVDLQQLAPDWGIEEKSLRKLSAIVLGKRVSKAQRLSNWEAAQLTEKQMRYAATDAWICPEIYRTLQHTLKPNDK
>NZ_AP019739.1|WP_141411906.1|1944128_1946048_+|RecQ-family-ATP-dependent-DNA-helicase
MQPLDDIHAELLGTLKRYWGYDSFRPVQEEIIRSVCQGRDTLALMPTGGGKSLTYQVPTMLREGLCIVVTPLIALMKDQVDRLRRLGINAAAIHSGLSMRQIDIVLDNCVYGDVKFLYVAPERLVTEAFRLRVERMRVSLLAVDEAHCISQWGYDFRPSYLRIAELRERLPEVPVLALTASATPAVARDIMRQLRFAEPHVLRSSFARPNLSYAVRHDEDKNEQLLRVVRNVAGSGIVYVRTRDGCEQLTEFLRDAGVAATCYHGGLANAERSIRQEEWLAGRTRIMVATNAFGMGIDKADVRFVVHYSMPDSLESYYQEAGRAGRDGKRAYAVLLVAPDDAERVQRRFDLQFPPLDEIRDIYEKVCSYLQIGIGDGEQASFVFNIHDFCAKFRLFGGKVASALKLLQQNGYLTLTDEMRNPARILFCISRDDLYKLRVVRNDLDHFIRTVLRLYDGVFTDFRPIDEQEIAAASGYKVEHVKELFKRLWQMRVIRYIPANQAPMLFFDCERLPAADLYIAPETYRRRQELAEERFSHMIAYAANETECRSTVLERYFGAADPAPCGVCDICLAARKRAKSAEAPLDEEILRQLDAEPLAVKELAARFRCDAERVLEAVERLQHAGKISTAESGKLAINR
>NZ_AP019739.1|WP_141419667.1|1942940_1943801_-|hypothetical-protein
MKHICLPILCAACAFVSCVSRRVAEQTVVQRDSLEAVVHAKDSLIEVVFADINAVTENLARIRTRENLVALARNDEGVRRPIEEIDADIAAIDRLLQENRQKIAALQRSSAQLRKADLRIEGLEKMIRGLDAQLTAKEGEIGRLRGELSQMKARMETLAEEAAARSTEVEHLSGEKAQLEDRLNTVYYIVGAEKALRDSGIVSKQGFIGRTLTVGDPGDHDLFIRADARTLTEILVEQKKATVVTPHPADSYELITNADKVVYKLVITDPERFWSSSKVLVVSYRK
>NZ_AP019739.1|WP_141418901.1|1941995_1942706_-|MBL-fold-metallo-hydrolase
MISLFKKKEAPVYPADTVTSRDGRPIVFTFFKHASLAVDFDGRRIYVDPVGEYADYAHLPKADAVLVTHSHYDHLDRAAVEQLMTPATAVVCDKTSAEAFDFDCYTMVPGAVTEPLDGIRVEAVAAYNTTEGHLQFHPREREDCGYVLTLGGTRVYIAGDSEPTPEMRSLEGIDIAFLPVNQPYTMTVDQAAEAVRALRPAIFYPYHYGEVEQITDLDRLAREVAGLTEMRVRPME
>NZ_AP019739.1|WP_141418900.1|1939731_1941513_-|BACON-domain-containing-protein
MIEAATPAAVPAEGGAISIDYEVKNPVEGKRLSAQSDDAWVKELTVGDEAVTARLEKNLLADPRTATVTLRYDGAEAVKVSVVQEGYLPFLIQVADITMSDARITVYPEEEGMYIAAVDFAEGFDAQKIAAENKAIFAEHAAAEQKTLAEFIAGYAYKGEQTFHPSRLSPKSDYVVYAYGVDAEGNATTDVIVEPFKSLPVEPGPMVDCKIDIVAENLTSTSVKVVFNPSDPTVQYFYTMLDQAGYEDISKDWPGYIYEYMVSQLTDDGLPLSTIVMLSCSVGQQEVQSKTLQPETTYYACAVGVNSNATINTEVAVQKIVTPPDSPIDYGFDFDFGEVTATGARVTVSPRDVRAFYYWNVMTEEEYGEMKGDESKIAAYFEQKMIEQRKAQMGDYADWYPLPEFIASQCSSGFDGPDSYTFGTLTPETTYYVYAFWVDEQTGEPASVTAFSESPFKTEKQVISAAVAKPSLWLTDGDDWAELNPLGYGHFKGYAILGARIAPAEGAVHWYSNIYKASDIASTDDQLLASSLINSKYYMDKTSYNLSYGVEWGGDYVIVSVAVDAAGARGPVQRVAFKAEKSAAEPLESIPGE
>NZ_AP019739.1|WP_019131063.1|1952414_1953020_+|RNA-polymerase-sigma-70-factor
MIFQSKYDLDDNRAVIRRLHRGDMACFEACYKFYYRGLCSFASRWVPVSTAEDIVQDAMLYIWENRDKLLEELSLKGLLFMIVRNKAFDRIAHRQVRQRVHQQLSERFAERFESPDFYLGSELSRLYDEALARLPEQTRRIFEMSRRMGMTHQQIAAELGVSPQTVNYHISQALRTLGVALKDYLPLLLWLLSLSGRNDLV
>NZ_AP019739.1|WP_141418907.1|1953121_1954087_+|DUF4974-domain-containing-protein
MIEIDDTLLIEFLGGKLDATTSAEVERWYDASDENRRRLERLYLVFFTGERLSAAAAVDPNLSWQTLRRRIEAHRRPAPTKRLRTVVRYAAVFAVGLLTAGSLLFPYRSADDRTCTVTTEERACSIRLSDGSNVRLMPHSQLRYASDFGSEGRTVHLTGEAFFDIRKMADAPFTVDAGKETRTVVRGTKFNMKAYDDCSDIETTLIEGVVDFHAGDRTVTLSPGQKISYNPANRKLMLREVNVDAELDAQLRSFQYVRLSKVAESIGTHYGCDIAFGREALGEILFTGTLDYNMPLRHVLEIVTLSTDTRFTRNGDKITIL
>NZ_AP019739.1|WP_141419668.1|1954327_1957507_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MIRQIEAQTSYKVSYQGNLADNITIKADPSKHNVEELLADALRGTGISYVIRYNTIILTQEQPRAEAAQQASQTRHIAGRVIDAETKEPIIGATVWVKDSALGTNTNVDGAFDYTFTGHYGYIAVSYIGYQTQEFPVTNLPKVIELSAGNELDEVVVVGYGTQKKASVVGSIASVSVNDIRMPTAKISNNLAGQLAGVISVQRSGEPGASSTFWIRGISTFGSSTTPLVLVDGIERDLDLVDIEDIKDFSILKDAAATAIYGVRGANGVILITTREGIVGKPQINIRFEAGMVQPTKVPDMLDAVQFAELWNAAAGSEVYTPEVIQKYRDGSDPDLYPNVDWVDYLYKDLSFNERVNVNVTGGGSTAKYYISGGFYNEDGLFARDNMKEYNTSVFFRKFNFRSNVEVQLHKYTKLNVNLATTFERKNEPGTAASTIWDYAVKSAPNVFPAVYSNGLLPGPGANNGENPYVLLTQTGYREKFYNTAQSLFSLTQDLGDWVTKGLTVTVKGSFDAKNYNHLARTKTPPQYMASGRDEFGDLILQQKVIGADNLTYSESHSGYRSVYLEASVNWARSFGKHDLSALFLYQQSQRNNVGIDKSQPELALPYRHQGIAGRITYSYDNRYFIEGNFGYNGSENFSPGKRFGFFPSVAAGYVISNEKFFEPVRGVIDLLKIKASYGIVGNDKIGTGDNVRRFIYNETVVPGNSYNFGTSTQSYAGTRLGDWANPNVGWEEAHKLNVGVDLSLFSKLKISADYFKERREGIFLKRASIPVYVGLSTKPWVNIGKMRNSGVDASLEYHQTIGQDLHLTVRGNFTYARNMIVDQDQPDYKYLYMNRTGQARYQTFGLVAAGLFRDQADIDAWPKQSFGDVEPGDIKYLDLNGDGVVDSYDVKPIGYTAIPEIVYGFGFSLQWKAFDFSAFFQGVGHVNFSTRTDQTQGFIARNSREANLFSDVYDNYWTPERLDAKYPRLFIGTNNNNNQNSSFWMANGRYMRLKNLEIGYTLPKHISQKMAMQNMRVYLSGVNLFTFSPFKLWDPDLQTGATNYPNNRIINIGLTIGF
>NZ_AP019739.1|WP_141418908.1|1957523_1959404_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKNILKTFGLLLLSGTAFVACDDYLDRQPDEQLTAAQIFQKAKTTEQYLTNVYGYQSNYSDPSGQILPWSCCDDDGSIVFTGRNYSLINYDTWNPNNDIYRSQTYNNLYKGIREANYFMQHVFECPEMSEIDKGYHYNEARFLRAYYYSLLMSAYGPVFLIGDDPVDFTQEGLNERERNTWEECINYVANELWETSKGLPDVWTGETANYGRATKGAALAIRSRMLLYSARKLFNGNDLYKGVIDKYGNPLFPTVYDEKKWETAAQAAKDVIDLNIYGLIGADGTDPYTSMHDLYTKVGPVNGVTERIFSYLVTAYNWGVSTTPRAARTRAYGSYGPTQKLVDAFAMANGRYPITGYTNGDQAQPIIDPESGYSETGFSTFTHPIYGDELKNTFMMYQNREPRFYINVFWSGMTWHSGNVKKTDMQFYNGGNSGYGATQQNYTATGYLAHKFIDYTRDTATNGDKYDIATWGYLDWPIIRYAEILLNYVEALNEYDPGNPDILTYLNMVRKRAGVPDIDKVYPEAVGNQTQMRELIRRERHVELCYENLRYFDIRTWMTAETEHGDVYGMNVDAKDHKPNGDFWKRTLCAHDSARDGHRKFSPRGYLFPISQEEMDRTNCTQNYGW
>NZ_AP019739.1|WP_162502187.1|1959426_1960743_+|DUF1735-domain-containing-protein
MKLKQFIIPVAGALLLGGCEADHRNDNLLDSVVYLLESDLQKALFYDIEETIDYSFRAFSSGYTVTPSELGIELSDDVLTAYNEANGTAYTALDPACYRLVNSTGSVDADHPSTTFTVQLDCSAIKQLGDLTSYVIPLRLTSSSSKVNEELGSILINPEMAETQVLVRNAGVVECDLGSSQTLDFTAYVEFDNKWETTTEYVYGDEVLDAYNAEHGTNYLPIPTDAVTFTPAQLEVGKREAVSHFEIDKSKLTPDRFYTLAVQLKSNSEFKIGADNTVLYHIALNPLFTDRSKWILVACSSWYTDRGPELTIDGDVSTKFENRYNDIGQGDIETLPVTIDWDLGKTCYYAGMKLTRRNDSYVTDLKAGWIEMSDDGKTWMPLQSFDFEGSKTVVGDFRSEQWFGAGRYLRLKMTESGRPGRKLVSVCEFEPVLIDAGE
>NZ_AP019739.1|WP_141418910.1|1960826_1962170_+|hypothetical-protein
MTCSLIFAAAGFCLAATNCSNGNKTSDTPPALSFENASKTLEVGETYRPTLRIRHDGDANDTAYDMDGNPLGVTFRSSSPQTVSVDARGIVTGRNVGTATVTAETASGDARCAIGITVRSSNTTWIDAPLSDGIIFSRFVQLPANTVMQGFDVDSRGEIFYTQVTDRYKILVSRSMPDRQATEYMTLCFHGHSSNMAVEEAGDERFVWVGNYANRVDDGNYWHEQVVSRIRYNPGSTHYPWNSDENYFIEAGCLNMNPAVDAANDQLAILYTRVDTPGRYCWVVYSLSEAKALPEETVTLQPLSYGGETESYPLRKDVTPEVRVRNLSRLQPLARFSIPTPAIAWQGYEIHDGRMYLMEGTSGNNDGTTGEAYMTVYDFEGRIVQSRTKVRAVSDLKALTEAGITESGYIESEGVKIRRGKLFLGFASQSKKDGNRRRANIFQYELP
>NZ_AP019739.1|WP_141418911.1|1962368_1963979_+|alpha-galactosidase
MQRLLAFFFAAALLWTPAWSQSAPDALVPDLSQYILTPPAPPTPRINGAKVFGARPGSEFLFAIPASGDRPMTFAAEGLPKGLSLDPSTGFITGRVKKPGTYLVKLTARNALGEATRELRIVIGERIALTPPMGWNSWNCWARDVTQEQVLSSARAMVESGLVNHGWTYINIDDGWQGRRGGRYNAIQTNDKFPDMKELSEQVHAMGLKLGIYSSPWIGTYAAHIGSYSDNPDGENQWIKDGNHNENFRYEKPGGNYWQDRKEMYRHGAYSFVEADARQWADWQIDYLKYDWNPNDLYHVKEMHDALRATDRDIVYSISNSAPYADAPLWVEYTDCWRTTGDIRDTWKSISSIGFEQQRWAPFCGPGHWPDADMLVVGLVGWGPKLHYTKLTADEQYTHMSLWAMLASPLLIGCDLARLDPFTKSLLTNDEVIAVNQDPLGVHAAAIWEKEGRVIYVKHLEDGAMAVGLFNKTLEPAKIGFTLKQLGIRGTQVVRDLWRQKDLTTTDKGFETQVPPHGVVLVKIAPGNPTRNDLKK
>NZ_AP019739.1|WP_141418912.1|1964064_1966011_-|membrane-protein-insertase-YidC
MDKKSIIGIVLIGILFFGFTIYSSRQQQKYQEELAAYQAAHPELTQPVVPDSSAVAAAPVVESLGAATPDSTRLAREVAVLGDFLAAAKNAAPQEIVVENDVMKVRFSTGGGIVRSVTLKDYTRYGRQGERNEPIEMFVPESAKFDLSFFIKNGLNNVKVNTSEYTFTADPVIRTDTAQIVRMRLPVAEGAALEYRYVVYDEATPSRDYLVDYTVRLVGMAPYMANQSSIGIAWSNTSYQNERGFKNENMYTTVAYRVPGEGSIDDLSMSEGAKEEKISSSVEWIAFKQQFFSSVLIARDDFLYADVAYDTASPDSGLIKAFSATMAVPYTAQTEQYDFSFYFGPNKYAVLKKIDDAQGQSLLLDRLIPMGWGIIGWVSRWLVIPVFDFLRQYIPSFGWIILILAILIKIIVSPLTYKSYISQAKMRIIKPEIDALNAKYPKQDDAMKKQQEMMALYKKAGINPLGGCIPMLIQLPILIAMFRFFPSSIELRGQSLWWAHDLSSYDSILNLPFSIPFYGDHVSLFALLMALSTFGFSYMSYQQTASAQPQMAGMKFMMVYMMPIFMLCWFNDYSSGLCYYYLLFNLLTIAQTFLIRRMVDDGKIHAVMEANANKAKNKKKSKFQLRYEELMRQQEAQSRSGKKGTKRK
>NZ_AP019739.1|WP_019131071.1|1966035_1967655_-|CTP-synthase
MKLKKPKYIFVTGGVASSLGKGIISASIARLLQARGYTVTIQKLDPYINIDPGTLNPYEHGECYVTEDGTETDLDLGHYERFTSITTSKANNVTTGKIYKSVIEKERRGDYLGKTVQVIPHITDEIKRRIQLLAQQKVYDIIITELGGTVGDIESLPFIESVRQLRYALGYRDTALVHLTLIPYMAASGELKTKPTQHSVKALMENGLQPDILVLRTERALSQGLRRKVALFCNVDANAVMESIDVPTIYEVPLRMHDQHLDEVVLSKLDLPADCEPDMEQWKAFVEKVKNPHHKIEIALVGKYTELPDAYKSISEAFIHAGAMNDCKVKLRYVNSEKIDDANVDEILGRMAGILVAPGFGNRGIEGKIAAVKYAREHGVPFMGICLGMQCAVIEFARNVLKMKDANSTEMEPSTKHPVIDLMEEQKGVTAKGGTMRLGGYPCQLRPDSKAAAAYGATDIVERHRHRYEFNNDYLGDFESHGMIPAGVNPETGLVEVVELTGHPWFVGTQYHPEYKSTVQRPHPLFVAFVAAALKYSGN
>NZ_AP019739.1|WP_141418913.1|1967757_1969896_-|DUF349-domain-containing-protein
MATKITNPSVPEEQVSNAEDVQKTSASEAPAAELVTVAVPAEDPAGEPVAAAVGETAAEPPVEAAAPAEEPVGAAPVEEPETAVPAVAFAGEAGAAPAEGIDFADEEAALAARSAGLDEEEPADGEAVDEGAAGASDALFDGRSEEEMVSLFAKMLDEEPVQSLRRVVEAVKIAFYKAHRAEVEAQRRAFVEAGGDEAEFVPAADAQELRLKDLFKEYRRRRDEFIASLDAEKEANLKIKLQIIEELKELVNSDETLNHTFTKFRELQQRWKETGLVPQQNVKDLWETYNLHVENFYNFIKINKELRDLDLKKNYEQKLALCEAAEALVLEPSIVEAFHKLQKLHDEWRETGPVANEFKETLWERFKEASSRINKQHQAFFENIKAEQTKNLELKAGLCEQTEELAQQLYTTRKEWNRASDRLLEIQKVWKTIGFAPKKDNTRIYERFRTACDRFFEAKRRFYADVKTEMEHNLQLKNELCEAAEALQMSEEWKKTTDELIALQARWKEIGAVSRRYSDQVWKRFRAACDKFFERKAAHFSDVDGQYEQNLVRKQALLDEMAAADVKEGGFEMIKEFQRRWSEIGFVPIKRKDEIQKRYKECVDTLFSVLRGSERDRSMSRFREKVSAFKASGDRRIRTERDRLYNRVKQLESDIALLENNIGFFAHSKGAEALIADVREKIERAKREMADTIEKVKLIDREAARESEDREA

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Crispr_ID: NZ_AP019739_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_15

2037924-2038017

Orphan

Consensus_repeat	Method
ACTCGAATTGCCGAGGCGAGAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_15

>merge|NZ_AP019739|15|2037924-2038017|CRISPRCasFinder
ACTCGAATTGCCGAGGCGAGAAATGGAGCATGAAAATGAGCGTTTTCGTTAAGCCGAGCGCAATCGGGCTCACTCGAATTGCCGAGGCGAAAAA

>NZ_AP019739|15|14|2037924-2038017|CRISPRCasFinder
ACTCGAATTGCCGAGGCGAGAAA	TGGAGCATGAAAATGAGCGTTTTCGTTAAGCCGAGCGCAATCGGGCTC
ACTCGAATTGCCGAGGCGAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_026075030.1\|2031657_2032905_+\|beta-ketoacyl-ACP-synthase-II	unknown	unknown	gnl\|CDD\|274452
NZ_AP019739.1\|WP_141418942.1\|2030480_2031182_-\|dipeptidase-PepE	unknown	unknown	gnl\|CDD\|179990
NZ_AP019739.1\|WP_019131128.1\|2029113_2029956_-\|prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|181452
NZ_AP019739.1\|WP_141418948.1\|2042059_2043334_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235393
NZ_AP019739.1\|WP_019131131.1\|2031360_2031597_+\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|179197
NZ_AP019739.1\|WP_141418943.1\|2033737_2034391_+\|DNA-repair-protein-RadC	unknown	unknown	gnl\|CDD\|178801
NZ_AP019739.1\|WP_026075031.1\|2037419_2037848_+\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|340815
NZ_AP019739.1\|WP_141411965.1\|2049459_2051439_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NZ_AP019739.1\|WP_141419671.1\|2046200_2049434_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_141418941.1\|2029959_2030469_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP019739.1\|WP_141418950.1\|2051497_2053096_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379837
NZ_AP019739.1\|WP_141418946.1\|2040963_2041527_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239516
NZ_AP019739.1\|WP_141418944.1\|2038045_2038591_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
NZ_AP019739.1\|WP_141418947.1\|2041756_2042083_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_019131137.1\|2035766_2037311_+\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NZ_AP019739.1\|WP_162851483.1\|2038960_2039287_+\|multidrug-efflux-SMR-transporter	unknown	unknown	gnl\|CDD\|224987
NZ_AP019739.1\|WP_141418949.1\|2043686_2046137_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141411958.1\|2034445_2034994_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141418945.1\|2039329_2040634_-\|serine-dehydratase-subunit-alpha-family-protein	unknown	unknown	gnl\|CDD\|226206
NZ_AP019739.1\|WP_034780620.1\|2032991_2033708_+\|ribonuclease-III	unknown	unknown	gnl\|CDD\|274024

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_026075030.1\|2031657_2032905_+\|beta-ketoacyl-ACP-synthase-II	gnl\|CDD\|274452	TIGR03150, fabF, beta-ketoacyl-acyl-carrier-protein synthase II. 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis].	0
NZ_AP019739.1\|WP_141418942.1\|2030480_2031182_-\|dipeptidase-PepE	gnl\|CDD\|179990	PRK05282, PRK05282, dipeptidase PepE.	6.52926e-123
NZ_AP019739.1\|WP_019131128.1\|2029113_2029956_-\|prephenate-dehydrogenase	gnl\|CDD\|181452	PRK08507, PRK08507, prephenate dehydrogenase; Validated.	7.72966e-132
NZ_AP019739.1\|WP_141418948.1\|2042059_2043334_+\|hypothetical-protein	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0.00016259
NZ_AP019739.1\|WP_019131131.1\|2031360_2031597_+\|acyl-carrier-protein	gnl\|CDD\|179197	PRK00982, acpP, acyl carrier protein; Provisional.	2.03343e-32
NZ_AP019739.1\|WP_141418943.1\|2033737_2034391_+\|DNA-repair-protein-RadC	gnl\|CDD\|178801	PRK00024, PRK00024, DNA repair protein RadC.	3.202e-61
NZ_AP019739.1\|WP_026075031.1\|2037419_2037848_+\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|340815	cd16964, YqgF, putative pre-16S rRNA nuclease YqgF and RuvX family. Escherichia coli YqgF has been shown to act as a pre-16S rRNA nuclease, presumably as a monomer. It is involved in the processing of pre-16S rRNA during ribosome maturation. The RuvX gene product from Mycobacterium tuberculosis was shown to act, in a dimeric form, as a Holliday junction resolvase (HJR). HJRs endonucleases specifically resolve Holliday junction DNA intermediates during homologous recombination. Holliday junctions are formed by the reciprocal exchange of strands between two DNA duplexes. HJRs occur in archaea, bacteria, and in the mitochondria of certain fungi; they may form homodimers and display structural similarity to RNase H and Hsp70.	1.07121e-42
NZ_AP019739.1\|WP_141419671.1\|2046200_2049434_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_141418941.1\|2029959_2030469_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.33533e-11
NZ_AP019739.1\|WP_141418950.1\|2051497_2053096_+\|hypothetical-protein	gnl\|CDD\|379837	pfam16370, MetallophosC, C terminal of Calcineurin-like phosphoesterase. This is the C-terminal of Calcineurin-like phosphoesterases. It is around 150 residues in length from various Bacteroides species. The function of this family is unknown.	5.89829e-33
NZ_AP019739.1\|WP_141418946.1\|2040963_2041527_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	3.28737e-41
NZ_AP019739.1\|WP_141418944.1\|2038045_2038591_+\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	2.41424e-67
NZ_AP019739.1\|WP_019131137.1\|2035766_2037311_+\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NZ_AP019739.1\|WP_162851483.1\|2038960_2039287_+\|multidrug-efflux-SMR-transporter	gnl\|CDD\|224987	COG2076, EmrE, Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism].	7.55033e-29
NZ_AP019739.1\|WP_141411965.1\|2049459_2051439_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	1.63907e-34
NZ_AP019739.1\|WP_141418945.1\|2039329_2040634_-\|serine-dehydratase-subunit-alpha-family-protein	gnl\|CDD\|226206	COG3681, COG3681, L-cysteine desulfidase [Amino acid transport and metabolism].	9.50313e-128
NZ_AP019739.1\|WP_034780620.1\|2032991_2033708_+\|ribonuclease-III	gnl\|CDD\|274024	TIGR02191, Ribonuclease_3, ribonuclease III, bacterial. This family consists of bacterial examples of ribonuclease III. This enzyme cleaves double-stranded rRNA. It is involved in processing ribosomal RNA precursors. It is found even in minimal genones such as Mycoplasma genitalium and Buchnera aphidicola, and in some cases has been shown to be an essential gene. These bacterial proteins contain a double-stranded RNA binding motif (pfam00035) and a ribonuclease III domain (pfam00636). Eukaryotic homologs tend to be much longer proteins with additional domains, localized to the nucleus, and not included in this family. [Transcription, RNA processing].	4.07888e-61

>NZ_AP019739.1|WP_026075031.1|2037419_2037848_+|Holliday-junction-resolvase-RuvX
MGRIIAIDYGTRRTGIAVSDPLQLIAGGLATVETRELERYLTQYIAREDVSVIVVGKPLKMNGAPSETMRFVLPLVARLHRTYPSIEVVLYDERFTSAIAHRAMLDGGLRKMARRNRALVDKISATIILEDFMSSRRAEQHR
>NZ_AP019739.1|WP_019131137.1|2035766_2037311_+|glycine--tRNA-ligase
MTQDELFKKLVAHCKEYGFIFPSSEIYDGLGAVYDYGQNGVELKNNIKRYWWDSMVKLHENIVGIDAAIFMHPRTWEASGHVSAFNDPLIDNKDSKKRYRADVLIEEWIAKQDEKIEKEVEKARKRFGESFDEEKYRATSPRVAETAARRDEVHARFAEAMNANDLGGLRQIILDCEIACPISGTRNWTEVRQFNLMFSTQMGSTAEGANTIYLRPETAQGIFVNFLNVQKTGRMKLPFGIAQIGKAFRNEIVARQFIFRMREFEQMEMQFFVRPGEEMKWWNQWKETRMAWHRALGFGDDQYRFHDHEKLAHYANAATDIEYNFPFGFKEVEGIHSRTDFDLGNHQKFSGKKMQYFDPETGESYVPYVVETSIGVDRMVLQVLSAAYREEQLENGESRVVLAFPPALAPVKVAVMPLVKKDGLPDVAQRIIDQLKYDFNVVYDEKDSIGKRYRRQDAVGTPFCVTVDHQTLEDGTVTVRHRDTMQQERVAIDDLYRMVDDEVSYRKLFRKLNL
>NZ_AP019739.1|WP_141411958.1|2034445_2034994_-|hypothetical-protein
MDIKFFVPYVEAKKRLDIRASIVGRWLEAGSYEDRRGDGVWRRVRTSRMNRDFSVWLLDFKSRGRLVRTEVAPGRRRYGIVPDIDPGEIPDLKELPYVAGTQSVQHDAETDSYYEVGEAGLLSVRRGYSDYMDYRFNRRSGELVLPEGRMLVMRLDEEEMWVMDHDQYELEYPTVERFRRLK
>NZ_AP019739.1|WP_141418943.1|2033737_2034391_+|DNA-repair-protein-RadC
MKQLLDKLTSRGSASLDDTELLTLLLGEGGEQAAARRLAERLLEYYDGALARLGRDPLPRLRMVEGMGQRRAARIAAAAELGRRILQAQAAETTTLVTSDDVIRLFRPELEQLDHEECWAVYLSSSNRIIERQRISQGGVQGTVVDHRLIVKRALELLATQLILVHNHPSGSAEASEPDRMLTARIAQAAALFDIRLLDHIIVARAGSFSFRSTGLL
>NZ_AP019739.1|WP_034780620.1|2032991_2033708_+|ribonuclease-III
MFGFVPHNIELYKLALIHKSASLVLEDGRQINNERLEYLGDAVIEAVTSDYLYIEFPDRDEGFMTKLRSKIVSRQSLNAIARQIGLDRYVILDGSSNTLAQKHIFGDAFEAMMGAIYLDQGYNFVNRLLINRLFREHLSLEELTESENDFKSRLIEWCQKNHHTIRFRTTRQENSAANHPLFRSTALIDNMEVGHGSGESKKEAEQQAAYSVSQSFSDETCAALLDKVDRLRLGGESR
>NZ_AP019739.1|WP_026075030.1|2031657_2032905_+|beta-ketoacyl-ACP-synthase-II
MTARRVVVTGVGTINPLGNTIQEYFSNLEKGVSGAAPITHFDTEKFKTKFACEVKNYDPSQYFDRKEVRKYDLFTQYALIAATQAVEDAGFDMEKLDKEQAGVIWSSGIGGLKSFFDECTGYAEGGNTPRFSPFFIPRMIADIAAGFISMKYGFMGPNYCIVSACASSNHGMIDAFNQIRWGKADVMVTGGSEASVNEPGVGGFSSMQAISTRNDDPQHASRPFDVHRDGFVIGEGAGALIFEEYEHAKARGAKIYCEVVGGGASADAHHFTAPHPEGKGAILSMKAALKDAGMQPEEIDYVNVHGTSTPLGDIAELKAVAGVFGDHVYDLNISSTKSMTGHLLGATGAIEALACILALTRGVVPPTINVEELDPEIDAKLNLTLGKAQHRDVKAAMSNTFGFGGHNSTIIFRKF
>NZ_AP019739.1|WP_019131131.1|2031360_2031597_+|acyl-carrier-protein
MSEVQQKVVEIIVDKLGVKESEVVPEASFTNHLGADSLDTVELIMEFEKAFDIQIPDEDAEKIATVGDAIKYIEEHKK
>NZ_AP019739.1|WP_141418942.1|2030480_2031182_-|dipeptidase-PepE
MRLLLISNSTNAGEAYLAYPMPRIGEFLRGVREVAFVPYAAVTFSYADYERRVQARFSELGIRVRSVHRAADPAAMIRRAEAICVGGGNTFALAKKMQEQGLMRAIRNRVKAGVPYVGWSAGSNVACPAISTTNDMPIVEPESFRAVGAVKFQINPHYLDANPEGHAGETREVRLLEFVAANPRRYAVGLREGCMLRYENGRLELLGSRPMRIFKKGLTPYEVQPGDDLSFLL
>NZ_AP019739.1|WP_141418941.1|2029959_2030469_-|GNAT-family-N-acetyltransferase
MMTIREIESGSDIMEVNRLAGLIWHEAYRGIVSREQIAYMIERFQSVRAITEQLALEGYRYFLMEDEGRAVGYCGVQPRDGRLFLSKVYLLHEARGQGRFRQMLEYLRGLCREVGARTIWLTVNRRNERAIGAYRRAGFREVRAQVTDIGGGYVMDDYIMELETTPQKE
>NZ_AP019739.1|WP_019131128.1|2029113_2029956_-|prephenate-dehydrogenase
MNVLIIGVGLIGGSFALALRDRGLAERIEGVEASEEHARRALERGLVDRIVTLEEGLPSADLIVLATPVDTIPLLTVKILNRIAPHQVVMDTGSIKGELCEVVAMHARRGRFVATHPMWGTEYSGPDAASRGAFAGRTAVICERERSDRDAVETVERLYGALGMPLVSMEPEEHDLHTAYVSHISHITSFALALTVLEKEREEQHIFDLAGGGFESTVRLAKSAPRTWVPILLRNKYNVLDVLREHIHQLQIMRRMIERDDAEGLTAAMQRANAIQKILP
>NZ_AP019739.1|WP_141418944.1|2038045_2038591_+|peptide-deformylase
MIYPIVIYGSQTLRNPSENIAPDYPDLAKLVEDMFLTLGEADGVGLAAPQIGKNIRLFVVDCTPWGEDHPELADYRRAFINAEIYERSEETSLFNEGCLSLPGLHEDVRRPVSIRMRYVDEKFVEHDEEFTGLPARVIQHEYDHIEGKVFTDRLSPLRRNLLKSKLQRLAGGKYRCSYKTK
>NZ_AP019739.1|WP_162851483.1|2038960_2039287_+|multidrug-efflux-SMR-transporter
MGYIWLTAAIAAELAGTTLLKYTEGFSRLWPSLGCVAAYVFCFYALSKALHYMPLSIAYATWCALGIVAATLLSVLLFREQLTLTGIAGITLVVAGVVILNLWGGASH
>NZ_AP019739.1|WP_141418945.1|2039329_2040634_-|serine-dehydratase-subunit-alpha-family-protein
MIPSSQRKAIADLLRREVVPAIGCTEPMAVALCTARARELLGGLPERIEVLLSANILKNAMGVGIPGTGMIGLPIAVALGAQIGRSECGLEVLRDVTPEAVARARDYLAADAVSVALKEGISETLYVEVHCTAGGRRAEAVIAGSHTRFVYLACDGEVVLDRRTGASSREEERCVPLTLRRVFDYALTAPIDELAFIDEARRLNMAAAELALGGEYGHSLGRTLRGRRELHVMGDSLFSRMLAYTSAACDARMAGAMVPVMSNSGSGNQGIAATVPVAVYARQTGASEERTRRALVLSHLTAIYIKQSLGRLSALCGCVVAATGSSCGIAYLMGGGYREVACAVQNMIANLTGMICDGAKPSCALKVSSGVSTAVMSALLAVEGKCVTSAEGIIDDDVDRSIRNLTAIGREGMAATDRLVLDIMTHKKPADCER
>NZ_AP019739.1|WP_141418946.1|2040963_2041527_+|NUDIX-domain-containing-protein
MKQPDHRPWKVLNSEYLAHEPWFTVRREAVELPGGARIPSYYVLEYPDWVNVIACTDDGRFLLIDQYRHGLGRTSYEIVAGVRDPQDATPLDAARRELYEETGYGGGEWKEYMVLSANPATHTNLTYTFLATGVQPLSTQHLEASEDIRIHLFTFEEVRRLLEENCIPQALMAAPLWRYVAEHSERR
>NZ_AP019739.1|WP_141418947.1|2041756_2042083_-|hypothetical-protein
MVGRGLVHSQEDEILAADEPCGVDPLRIAQLAGVRFEPVAVTERRVELELLEFVVEMEGGGIPVARGAAFMQIVAVGVDPVEFEPDRLFAFGYERIEPSEKFVLGEGQ
>NZ_AP019739.1|WP_141418948.1|2042059_2043334_+|hypothetical-protein
MYKAAADQLEAIPAHGPEFDSVDYYNCYLKLYHTMAQTAMAGPLQREYRRLKGLYRDSVLLVVDRNRLTCTLMRHDKRYEEGGDPQESIRELNAFFSRNDNSTPNKAVIANSLADAYGRLGDDEQRLRYLTLTAIYDLEVPSLAYSALPRLADLLFRRGDLVRANRYITRSLDDAIDCNSVNRILIASRTMTEINQSFMQEIARHQHRLYLLLAVVTGTILLLTGILVFTLRQKRTIKQLQTQHANDNERLRELNERLSVINRQQETINDELSKANTVKDKYIRHYMQLSTLYINKLERFRVQLFKTFNTHGLDRLLRELRSPSSTEREYKAFFNEFDTVFLSIYPDFIEQINALLHETERLKSTKLNTEFRLLAVIRLGITDNAQIAQFLHISINTVYTYRNRLRNAATIPPQEFEKRILEIR
>NZ_AP019739.1|WP_141418949.1|2043686_2046137_+|hypothetical-protein
MRKSLLFLLNTLLAAATLCVVSCGIDDVDAEDGAIQFELYDTEGTLIEGLQSMKFGATTAYTLKSAFVTYTEVTAPAGWKCSVIPSSRSCTVTAPVASDLEAEAGGDITIAITSQAGRTMSYTLSVAALEESISLTFDGDATTKNHIFSYGKSLVFPFSCENTSSLKVEAPEGWTTETDLENNQLTVTAPMPDSQNPTLTGAVKVTPLSVRGTAGESSSISVELSTKMPVIQFAEPIDRFVFGEQRNIPCTMQYVDKCDITAPEGWTVELDIAASMLKVTAPAEGVGIPAGTVTLDAVSAEELTESFETQLSLKGIATGDDFVAFGKAVTEAAPLDEFMQEGTVILLQDVDLSAFSQTCFVGQAENPFTGTFDGKGHTLTVSLNDGDAKELGLFHTLDATAAVKNLTLAGSMTVTQPNPGVAGTLAIYNNGAALTGVTNTATVTYSADKTNSTSGYLGGLVGQDKAGSTYTDCHNTGMFNIPGSGRTMFIGGIVGGALINTKGSLTNCSNSGKFEFNFSNKPDSGMFGGLVGSAEKAFWNFTDCTNEGNFSVTFADPGHQYHSLGGILGNGYGTFVRCINKGDITFGTAKGTNYRRTGGIIGCVGANDDAIDFQRTLSMSDCRNEGDLAASTASLGGIIGIAEKIDTPAVIENCENKGHISSPSMADYDVYYFGGIAGKVNGAFTLRNCVNRGNLTAAVERDIAGIAVSGGNDAVFENCENYGNITVAPNHKPNEGDRWRPCVAGIVAIENDVATTITNCTSDCVIDATVYRATSIDKVYVFQKTWENGTEDTKTVCDEASKSNSAGTTINITTRE
>NZ_AP019739.1|WP_141419671.1|2046200_2049434_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MCLFCLGEAAVASPGKADAAPAAQAQSSKLTVKGFVKDDKGDPMIGVTLIVKGTNFGTVSNADGSYSIDVPYGGATLMVSYIGYAPQEINVNNRTKIDITLLEDSKALEEVVVVGYNVQKKETITGSIATITTKDLKQSPTANINNALAGRMPGLLVNQFSGGEPGNDAAQLNIRGISTYGQSGVIMIVDGIERDMSYLAPDEIETFTILKDASATAPYGIRGANGVIVVTTKRGRKGEKPTVDFKASVGISEPIRYPDYLGSADYATLYNEAMLNDNPSLAADSPSLFTQTAIDNYRRAKGDNSDGLGYNWDYFDYAFQPSVLQDYSLSVRGGTDRARYFILGSYYKQGGNYKHSNSDNANNFLRYNFRANVDVDATKRLKISVDLGARVTEYTYPGATAANIISLANTQPPYLPIVLPNNGNEVNQGDFEENGGYLLYADNDYRYNMLGQLSRSGFSKRTRRYLQGSFKLSHDLDFITEGLSIAAQFSYDTFNQHTINNSVPTHSTGNLTYPGYSTWMLPEEYSIDEWKNNSAYWIQNGSYVTANQRTTDDAQGNSLSHANPEGTSRFQARLDYARKFGDHNVTAMVLYYMQNKIVGKEVPYRYMGFSGRATYDYKNKYLFEFNIGYNGSENFARGHRFGVFPAGSIGWVVSQEEFMKNVRWIDHLKLRASYGLVGNDQMGSTRFAYLQYYTSGSNMNIYFGEDKKAFGTTLIEGIFANPSLTWEKARKFNFGIDAEFFHQRLTLSVDVFKEHRYDILTSLNTDDKLGFPYIVGQTAPIVNSGIVDNRGIEFQLGWDGRIGQHFRYWIRPNFTFARNKVKFCNEISYIDNNGRDCPWRYQTGRRVGENFCYIFDHFVADQDEADRLNAMNGGSGFAIWGPVQPGDVVYKDMNGDGVVNNYDRAAVGNPRTPEIQYGIPVGLSYKGFDFSMLWQGSALCSVQLSGPAVWDFPLYDQSRTGKVRKMHLNRWTPETAATATYPALHYGIHNNNKQQYSSLFLYDASYIRLKNVEIGYTLPKAWTSKAGIQSVRIYAQGQNLLTFDRLGDVDMDPEIKNGDGSWFPVQRVVNLGINMTF
>NZ_AP019739.1|WP_141411965.1|2049459_2051439_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKNILKYLLLCCSALSLFGCEDYLDKTPQGDKTEEDVFTRFNETEQLINRLYFYVRAADQPLVHIRYFSDSALADECEGSSAENGWSNKFNEGDWEPGAELYSKCNATTDAGACHTFWPALYQDIRCANVILEGIEKYNTPDSQVHPGTLSQRIGEVYFLRAYLHYCVLKSYGECPYVDYTVDPNNLPKFERENVHSIVEKICNDCDNAFSRVPERYLAEQFGRVEKGTCLALKAMARWIAATPLYNGSTLKGDNRNYASEYQRYDPARWDAAAAAAKAVIDFTTNTGEKRYSLYQGADKSNTTNFGNVDESNGKVYTRLWELFSGTARSLDAKKCEWIWFFLQAKTVGYHNDMYPPSSQGQAREVPVQEHVDEYEVIGPDGYGYPIYALKENHKALYGGLISEEDMAKAYDDANPYENRDPRFYRDITYHGAMFKGKWINTATGSDEINAANSTTTGYFTHKFFDGYYTKGMSGDWNMDAPLIRLATIYLVYAEAVTRSKGATDEVYNMMNDLRARSFMAPIPPAAKTNKELLLDYILRERRVELYHEKSRFFSTRFYLEPTSPTELAKESQWNALPGSNDEKAQQYFAKYGAYPKTQHRICGMRPVEDPDGKISVGGKKYRMERFWKEDRVFLEKHYLFPIPTEELQRANIQQNPNW
>NZ_AP019739.1|WP_141418950.1|2051497_2053096_+|hypothetical-protein
MKMNPIFNLLRRTMFAALAATTIACGGDDPVVPQLPGGGNNGQDGTEEEKPEIKPDEGITLYGLVSDSEGNPLEGVVVSDGYSVVATDAKGVYQIVRSANAKYVFISAPSGYEIPTQANYGSYQGTYQAANSLTGSSTKPYRADFTLTKLSQSDTRFLLFGLGDPQPDNDEHIKRFRTETVPDVKKIKADYTIPTVGIALGDILGKGDAQTFTSMKRALGETGVPFFTTIGNHDKSSVDYTGDTYRDVLGPRWYSFNRGEVHFVAMDNCLFSGQDYTGGFTDEQVAWLEKDLSFVPTSKMIVLYYHIPLRDTNYRNRQKVLDLISKYQNPTLMCAHTHYFQPYHMRSHNLFERIHGGTCGYFWRSNCGGDGTPNGFMVYEIDGTKIVDTYFKASQRPDDHQIRLYHGDAVFAGPYATYKYDLGADVVVANVFAAGMDGTTWKVELSEDGGKTWSDMSPIEQNYGDRWIRGYHIGVEHHPTESGTSPCYHQYQYKLKDAAATAIEVRATDSFGHVYTQDTFTADNDFTEAEKY

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Crispr_ID: NZ_AP019739_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_16

2536282-2536381

Orphan

Consensus_repeat	Method
CCGTATCGAACCCGTCGCCGCCGTCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_16

>merge|NZ_AP019739|16|2536282-2536381|CRISPRCasFinder
CCGTATCGAACCCGTCGCCGCCGTCGCCATAGGATCCCCCTCCGGCCGAACCGCCCGAGGAGGCGGAACCCTCCGTATCGAAACCGTCGCCGCCGTCGCC

>NZ_AP019739|16|15|2536282-2536381|CRISPRCasFinder
CCGTATCGAACCCGTCGCCGCCGTCGCC	ATAGGATCCCCCTCCGGCCGAACCGCCCGAGGAGGCGGAACCCT
CCGTATCGAAACCGTCGCCGCCGTCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_162851466.1\|2546178_2547204_-\|nucleoside-hydrolase	unknown	unknown	gnl\|CDD\|239118
NZ_AP019739.1\|WP_026075114.1\|2547792_2549154_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225180
NZ_AP019739.1\|WP_141412225.1\|2540621_2541248_-\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NZ_AP019739.1\|WP_026075115.1\|2549528_2550299_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_AP019739.1\|WP_141419205.1\|2550538_2552794_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NZ_AP019739.1\|WP_141419199.1\|2527147_2529796_-\|AsmA-family-protein	unknown	unknown	gnl\|CDD\|379224
NZ_AP019739.1\|WP_141419206.1\|2552812_2553472_-\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|319798
NZ_AP019739.1\|WP_141419202.1\|2534247_2536176_-\|fimbrillin-family-protein	unknown	unknown	gnl\|CDD\|372499
NZ_AP019739.1\|WP_141412224.1\|2538652_2540605_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|379837
NZ_AP019739.1\|WP_162851484.1\|2542768_2546068_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_026075107.1\|2525682_2526438_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_AP019739.1\|WP_034780528.1\|2524539_2525508_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419201.1\|2530759_2531665_-\|cysteine-synthase	unknown	unknown	gnl\|CDD\|107204
NZ_AP019739.1\|WP_141412218.1\|2526527_2527076_+\|outer-membrane-beta-barrel-protein	unknown	unknown	gnl\|CDD\|372635
NZ_AP019739.1\|WP_026075108.1\|2532129_2533506_+\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240548
NZ_AP019739.1\|WP_019131455.1\|2533521_2534163_+\|cytidylate-kinase-like-family-protein	unknown	unknown	gnl\|CDD\|379060
NZ_AP019739.1\|WP_141419207.1\|2553748_2554252_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_AP019739.1\|WP_141412226.1\|2541252_2542764_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|378943
NZ_AP019739.1\|WP_141419198.1\|2521714_2522791_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|366736
NZ_AP019739.1\|WP_141419200.1\|2529839_2530748_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_162851466.1\|2546178_2547204_-\|nucleoside-hydrolase	gnl\|CDD\|239118	cd02652, nuc_hydro_2, NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. .	1.45157e-49
NZ_AP019739.1\|WP_026075114.1\|2547792_2549154_-\|MFS-transporter	gnl\|CDD\|225180	COG2271, UhpC, Sugar phosphate permease [Carbohydrate transport and metabolism].	2.35393e-130
NZ_AP019739.1\|WP_141412225.1\|2540621_2541248_-\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	3.44504e-10
NZ_AP019739.1\|WP_026075115.1\|2549528_2550299_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	4.3055e-83
NZ_AP019739.1\|WP_141419205.1\|2550538_2552794_+\|sodium:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.57837e-65
NZ_AP019739.1\|WP_141419199.1\|2527147_2529796_-\|AsmA-family-protein	gnl\|CDD\|379224	pfam13502, AsmA_2, AsmA-like C-terminal region. This family is similar to the C-terminal of the AsmA protein of E. coli.	4.42725e-20
NZ_AP019739.1\|WP_141419206.1\|2552812_2553472_-\|HAD-hydrolase-like-protein	gnl\|CDD\|319798	cd04302, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to the Pseudomonas aeruginosa PA0065. 5'-nucleotidases dephosphorylate nucleoside 5'-monophosphates to nucleosides and inorganic phosphate. Purified Pseudomonas aeruginosa PA0065 displayed high activity toward 5'-UMP and 5'-IMP, significant activity against 5'-XMP and 5'-TMP, and low activity against 5'-CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.86832e-101
NZ_AP019739.1\|WP_141419202.1\|2534247_2536176_-\|fimbrillin-family-protein	gnl\|CDD\|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	8.85946e-05
NZ_AP019739.1\|WP_141412224.1\|2538652_2540605_-\|metallophosphoesterase	gnl\|CDD\|379837	pfam16370, MetallophosC, C terminal of Calcineurin-like phosphoesterase. This is the C-terminal of Calcineurin-like phosphoesterases. It is around 150 residues in length from various Bacteroides species. The function of this family is unknown.	7.99843e-39
NZ_AP019739.1\|WP_162851484.1\|2542768_2546068_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_026075107.1\|2525682_2526438_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.29748e-19
NZ_AP019739.1\|WP_141419201.1\|2530759_2531665_-\|cysteine-synthase	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	6.38102e-135
NZ_AP019739.1\|WP_141412218.1\|2526527_2527076_+\|outer-membrane-beta-barrel-protein	gnl\|CDD\|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	3.69415e-09
NZ_AP019739.1\|WP_026075108.1\|2532129_2533506_+\|MATE-family-efflux-transporter	gnl\|CDD\|240548	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.	1.63877e-133
NZ_AP019739.1\|WP_019131455.1\|2533521_2534163_+\|cytidylate-kinase-like-family-protein	gnl\|CDD\|379060	pfam13189, Cytidylate_kin2, Cytidylate kinase-like family. This family includes enzymes related to cytidylate kinase.	7.02269e-65
NZ_AP019739.1\|WP_141419207.1\|2553748_2554252_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.43258e-06
NZ_AP019739.1\|WP_141412226.1\|2541252_2542764_-\|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl\|CDD\|378943	pfam12771, SusD-like_2, Starch-binding associating with outer membrane. SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	1.48018e-98
NZ_AP019739.1\|WP_141419198.1\|2521714_2522791_+\|phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	2.5298e-12
NZ_AP019739.1\|WP_141419200.1\|2529839_2530748_-\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.79224e-30

>NZ_AP019739.1|WP_141419202.1|2534247_2536176_-|fimbrillin-family-protein
MIREMMCLLALAGVMAGCTNDGSSELQRPETTVRLTAELQQGSRTVLGDDGLKVLWENQDRLGVFSDKGDANVSFLLSEGAGESVGRFEGALSKGAVPQYVYYPYSADAGTSTATLAVTVDAEQTQNGTTASIGANDFKIGSYDAAQKRFSLRNKLSLLAFTVDDLTGSELFGQPLDRIVLAVDNRDLSGDFTADLTDPEAALTPVSASAESTLSFSGKPVLEKPVSGWLLVNPVVEEGDPMTVTLYAGSKKATLRVRASKRYEAGVRYTMPLDVNELVADGSMTVETLSEELPAPGIKVFRKTHGMIVAEFEQSVDTYETQGRTFNIRLLEGDKVLRSYDKYSFKYGGKNGTIYSYLYNRFAFGGLKAATSYTIRVQAVSTDAARFEDSAWTDISVTTDAAPVLGDKVLLYKDFEDARYGGSSIDNAWAHKVKGTQASIDYTEESVEDALPVSVCHPMGCMEDAFGTKQHASYRAVHWSDYAWSADKADNTGLFPVCGALKFGSASAIGKLTTPTLASLGVDAPANVVLSFNAAPYYEPNLATGKFETAPNQGSGTTVVVTVNGDGTFDDGTQTQTLRNRTPVETGADAKGYMEYTLHTLRVTGATGATTFTIATSLDGTGAVTGSNSCRMWFDDLRIERE
>NZ_AP019739.1|WP_019131455.1|2533521_2534163_+|cytidylate-kinase-like-family-protein
MNEKFVINIGRQLGSGGKAVGERLAERFGIPVYDKRLIKMAAEHSGFGQEFFEKADEKPAKGFFATLLGYLRSPFAGDDAIYNNPLSHDALFKMQSDVIRQLAERESCIFVGRCADYILREHPRCVNIFVSASREDRIERLVRTRRLTPEAAEQLMDSTDEKRADYYNYYSNRTWGAAATYHLCIDSSVLGIDGTAAFAEEFIRKKLNLARKD
>NZ_AP019739.1|WP_026075108.1|2532129_2533506_+|MATE-family-efflux-transporter
MTVIKGAATELGTERIRKLLVQYSVPAIIAMTASSLYNMVDSIFIGLGVGPMAISGLALTFPLMNLAAAFGSLVGVGAATLISMRLGQKDYASAQYILGNVVVLNFIIGLGFGLVTLLFLDPILYFFGASEATIGYARDYMSIILMGNVVTHMYLGLNSVLRSAGHPRKSMYATINTVVINTILDPLFIYGFGWGIRGAAIATVLAQVISLVWQFRLLSDSSELLHFHRGIYRPRKRIVKEILAIGMSPFLMNVTACFIVILINKGLKEHGGDLMIGAYGIVNRLAFFFVMIVMGLNQGMQPIAGYNFGARQYDRLMHVLKLTVIGATCVTSLGFLLGELLPHWAVAVFTTDEELIRLAAEGMRIVFLCFPIIGFQMVTTNFFQSIGMAPKAIFLSLSRQLLFLLPGLLFLPDILAGMGYNGSWGVWCSMPLSDLLASLVAALMLLRELRRFRKRMQI
>NZ_AP019739.1|WP_141419201.1|2530759_2531665_-|cysteine-synthase
MIYDNILGTIGSTPMVRLNHFSPNRQVNIFAKLEGFNPTGSIKDRIAVKMIEEAEREGRLTPGKTIIEPTSGNTGIGLAIVGIVKGYPVEIVMSEAVSIERRKIIRSYGAKVILTPAEEGTDGAIRYARAAVASAPDRYFMPDQFANASNYLAHYQSTALEIWQQTGGEIDYLVCALGTSGTLMGLSRFLKAMKPDIKVVCAQPTRGHYIQGLKNMEEAIVPDIYDPSKIDIQEMVESEEAIAMARRIIAREAIFAGMSSGAALLAAVRTAARIERGNIVVVFPDRAEKYLSTTMFDEFND
>NZ_AP019739.1|WP_141419200.1|2529839_2530748_-|glycosyltransferase
MPRLSLIVATYNRAEQLLTTLRSVAAQTAPAAEWECVVVDNNSTDDTAARFEEFRTAHPELPLRRVSETRQGLSWARNRGIAETTGDIVAIIDDDERIVPEFIAAYIAFFDAHPSVASAGGPIVAEYPAGRPAWMSRYTERPIANPIDLGPTPRPFPRGRIPGGGNMALRRTALGCYGAFDPQLGRRGARLLGGEESDLFARLRRGGEQCWYVPGAVMYHIIPPSKLTRGYFDRLCRNIGVSQRTRAAIDGGLLRLWTGEAAKWCATLGIALGYCLTGRVRRAAWLVRMRRQITAGLLTSAE
>NZ_AP019739.1|WP_141419199.1|2527147_2529796_-|AsmA-family-protein
MKKFLKIVAIVAVVFIAVALVVPLALKSKVGDIVKKEASELLTAEVDFRSLDLSLLRHFPHASVELEGLTVVCAAPFEGDTLASVGRISVVVDLMSLFGDSGYEVTKLLVDKAHLHARKLADGSVNWDVMKPSDEPAEEKEPAEADEPSAFRLRMRDVRLSEAVVRYEDDSTGMRAGVDPLDLRLSGDLSGERSDLDLRLEAHRLSYAAGGVALLRDADLTADVTLDADLKNKRFTFSDNRLSLNAIALSLDGWVALADDRTEMDVRVNSSKVEFRDVLSLVPAFYTRDFENLTASGQLTLDAWAKGVLAGDRLPAFETTLAVRDGSFKYASLPKAVTGITIDARAANPGGTADATTVDVPTFALTMAGNALRGSFSAATPMSDLRFKAAAAGKVDLGAVKEVYPLGDSIALAGVVTADMQASGRMSDIERERYEAIAASGRLTVEGVTAALAGLPEVKVRRAAMSVSPAALTLSELGVTVGRSDIEASGTLSNYIGYLLRDQTLRGRLDVRSSLLDLNELLGDASEASADTGAAAAPADTAAMRAVVVPQNLDLALGASLKKILFQKMVLDDFTGSLTVAKGTVSMNRLAMNAFGGRMSASGSYSTAADAQRPALKLKAEIADASFSTTFDQLDVVRRMVPLFEKTGGDYSMSLDLATRLTQTMDPDYATLQADGAIRSKNIRVQNIAVFDQLAAALKNDALRRIEAKDVDIRFTIRDGRIATQPFDLSVGGISLNLSGSTGLDQTIDYTARVTLPEGSAGGILTAVDVGIGGSFSSPKITLDVKNAVKDAVSNAIGEKLGLSVGSSEGKSADEIRADAKAKGDKLVEEARAQRDKLVGKASGKLARIAAQASGDALVSAAEKQAQKLMEQAEQQIAAQQQ
>NZ_AP019739.1|WP_141412218.1|2526527_2527076_+|outer-membrane-beta-barrel-protein
MKKIVSTFLLLFAVCGASAQLHVDLRVGASASMLSEQHLKLGLRGGVNIGYLFDEHFGLRTGLCYVMKGATTSSDVFDYASDRATRLSYIDLPVEATVGFRLSPTSRFDLHAGPYLSRLLRAKVPRTAPYTIRNWDTGICIGFDFIVGHFVIGPEVQYGLLRVTSSGNEHNIGYSFTVGYRF
>NZ_AP019739.1|WP_026075107.1|2525682_2526438_-|response-regulator-transcription-factor
MKTMQREFEALLDMQRFDAGELDYAVLDRHVARLTQLSQVVNSGITVFDMYRRRHVFSSYNFPDLFRYDMDRIASEDSDYFSARIHPDDLPDVHRNGIDCLRFMLGHKELIDNGKFLTEYRIEIGGRYVRVVEQFQVLECDRRGNIWLTLSVLDMSPNQGSFDGVRSQLFDFRGGRALPFAGGGASSDPLSEREREILRLIGRGRLSKEIAVELSISVHTVNTHRQRILEKLRADNSMEAVRYAAERGLLD
>NZ_AP019739.1|WP_034780528.1|2524539_2525508_-|hypothetical-protein
MRKFLTIFTLSLLAVSCIDNDYDLSDIDTDDIGIGDENSVFTCPLMTLRVAVADIVNEQGDLDGILAEADVWLPNRLPDGAEAVDVKRLTGGDGQQAQQAYVQTLLTALQEEIDADASDRKLEQIARQIYAEYREDFLPDYLPVDVDEAEYIAAFRTVYHQQATHDLIWENIELFAARYLTTNLRIDVRPFVLSGIDVGADVRDMIVGGDESKTSLSLFGDIATDLPVSFSAEPSFEAEVEGSDRTLFSFPSFTVFPTAEAPVEIEETSVSADALTVIFDQETRIELNMQLENYYPGRSLDLGQGITINLKVRKKGGLIFNV
>NZ_AP019739.1|WP_141419198.1|2521714_2522791_+|phosphotransferase
MKRIAEQFRLDGAVQSVATLGEGFINDTYIITTERARYVLQRKNRNVFTDIPAMMRNIEGVTSFLREKVRRAGGDPRREVMTVIPTHDGALYYEDAAGDYWAATLFIEDSVTCQSASTPELARCGGEGIGRFQRMLADYGEPLADILPGFHDIRFRFRQWDDALARDAAGRRASVAREIEWIECRRDEMLRFWQRVETGEIPRRVTHNDTKINNILFDRQGRVLCVIDLDTVLRSPCFNDFGDAIRTYANHGREDDENLDDVWLDMTMFRGFAEGYLSEARAFLTPAETDALAFSVRYITYEQVLRFLMDYLDGDTYYKIKSPDHNLVRTRAQYALLRSAEERYDAMRAIVAELAARP
>NZ_AP019739.1|WP_141412224.1|2538652_2540605_-|metallophosphoesterase
MKRCYKIALCCLFVLLGAVACTDDPVQEALSDDGRLVTGFWIASPLPVHAGQTLTMLGTGFAEGDVVRFESGTGSFESPLAQVSESFACTTVPAGMASGGYDLTLVRGAASQRLARVNLRITLDPTRIPDREGATIKGVVYCGLEPVAGVRVSDGFETAVTDADGYYWLASDKRQGYVFVSLPSGYEAESTDTTAPAFWAPLAEAADVCEQHDFELRRVDQSRHVMIVAADLHLANRPTATGDLRQFAEGFIAETTAFASAQSVPTYLMVLGDMTWDEFWYSNLYSLSNYRTTMQGYPVPIYHTMGNHDNDPYFAGDFAAEAAYRKALGPTYYSFDVGEVHYVMLDNTVYINTGGTEGSMGKRNYHSYVTDQQLAWLRDDLAALRDKSQPVVVGMHCPAMNNYNAAFENRESFNPAGKTQELFDCFKGFSDVHFLTGHTHYNANMERGAIFEHNVAAVCETWWWAGKLSGVGVCKDGSPAGYAVYEADGRELNWYYKGVGQDRDKQFRTYDMNKVREFYTPAVIEILSQWPRRADDGAGDDYFDVADNTVFINVWNWDSQWTLRVTENGRELPVERVWHRDPLHTICLDYARILNGLDPVNDWESLRHSHMFRVVASSPRTSLHVEATDRFGRRYEETMRRPKEFTADMN
>NZ_AP019739.1|WP_141412225.1|2540621_2541248_-|BACON-domain-containing-protein
MKTIHYLLLAAGLCVLTSACDDESSEGARLTFEPALESLEFTTEGGSQTFLLYSNVPEWSIRCRYGDEWIDVWPAEGDFDGRFSVTVDENDRAELRYDHLEIYAGGELMRTLEVRQQAPAPAIATNFTEKQVAASAASFDVLVTCNAEWRAEVSPEDEAWLSLGERTATRLNVVCAVNDTGASREGAVRLYIPGTACEVSLAVKQSNN
>NZ_AP019739.1|WP_141412226.1|2541252_2542764_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKTIRFKCYAACCMAFLGMGCTASFEEYNTNPNQMEMWEIGPESLLENLVFKEFECLLHRTWYINGELIQYTVSGSSLNAFHRYVISNGVPSDHWATQFQWAATADHMYRLALEQNDVNCQAIALTMRAFCMAHCTDGFGDVPFTEAFQGRDGLAQPLFDTQRSIYERLYEDLELANSLYDVSKSLKSPSRDLLYGGDMAKWKRFTNSLHLRLLMRCINRDGELGISERIRSLVSQPTLYPLFESNDDNATLFYTGVVPFVNYFKNTTYENFTTYGRRASASFVDRMAAIGDPRLSIYFVRRGDAWGGYPSGEPVDETTTTENVANLNWEVLAQSTSPFSVMRYDEVLFLLAEAAQRGVIAGVGAEEYYEAAIRASIGYWHGVDTSGAELPESVIEAYLQNVAYDGTLRCIIEQKYIALFWCGMEAWNEYRRTGYPELTIGSATSNDHILPTRFEYPVNTSTTNPVNYAQAVARLAESWPGGGDNMRTPVWWSLQAARQSQKP
>NZ_AP019739.1|WP_162851484.1|2542768_2546068_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MLRLLSLALLLAVVSGEAAKAQSRMVEGTVVGREGSQAAVPLVGVAVVVKGSLRNHAVTDLQGRYSIRVPSSTDTLQFTYLGYKPLERVVGSRTRLDVEMLSESQQVDAVVVTALGLTRKEKSLGYAVSTVGSEDLNNTVTNNWLNGMAGKVAGLNFDTSSAGPGGSIRVTLRGEGSLAYDKNEALFVVDGVPINSGMTSNTENGSYGSTVSTIDYGNGASDLNPDDIESVSVLKGPAATALYGSRAANGAIIITTKSGLKSGGLRVTFNSNVTLEQAGFWPDFQEEYGSGVYESAQIDGVTTPPEYSYWNVAADKSDTGQKITRYHARSSFGERYDPSKMRYIYSSRNWDTDEYTRKPWVVQDWYKGFFRTGVTYSNSISIEGGNGKGNSARVSFKDMRNDWIVPNTGYESQNLSFSFSTRISKAVTVSGKANYYRKNSDNLPSAGYSTASPLYALIWNPSSVSVDDMYAEWSEGRIAAMNAAGTTGSGNLINPSSDNPYFMVYEQLNTQDRDRVYGNVSVNVNIWREKLTLMLRGGMDLNNDFRTQRKPQYSIGHTKGWYREQTVRNFEMNTDFMFNYKDSFGDFHLSAALGGNRMYQKFQNVTQTAENLQEPDVFLLVNVDGRLLSSNTRREKGVNSLYGYVNLSWRDMLFLDLTARNDWSSTLAPGNNSYFYPSVGVSFLLDEALGFRERAPWVDMLKLRGSWANVGNDTDPYQLTAIYSNSDFQGGYRLSSAIQNYNIKPENIESWETGIEARLFGGRIGLDVAYYDSTTTDQIITVPADWATGAASKLINAGEVNNCGVEVALDLRPVETKNWRWDIGLNWSKNWNELVALAPGVEMWQLNSKLTVGSTVFTYAYPGGVLGRLYGIGYETAPEGSFYVDEAGKFVDCSGARIIDAETGNPVLTETLKDLGSIYPNYKAGLNTRLSYKGLSLAMTFTAQQGGRAYSVTSAVLSTLGKLENSLPGRYDGLIADGVNLHADGTYSKNRTVTRNVVEYYNLYAQYRNNIEQHVYSTSFLKLKELRLDYSFPEQICRRLRVVRSIQLGFFATNLFCWTKWPQYDPEVASWAGGSLSKGVETGGYPMTRTYGFNLKLTF
>NZ_AP019739.1|WP_162851466.1|2546178_2547204_-|nucleoside-hydrolase
MKRISMILFAAALLLPWCAGAAAPEKGAVPVIFETDMGNDIDDALALDLLYKGMDAGHIRLIGVSLNKRSSTSFEFIDLMNTWYGYPDIPIAYTPRAVDNKDRDYTTPVCELKASDGKPLFKRSRKPGSWEDPVAMYRRLLAAEPDNSVVVVSVGFSGNLAALLASGGDDVSPLTGRELVARKVKYFSVMAGSFGVKKRAEYNVINDIPAARKFFAECPSPIVLTPFEIGKQVVYPGRSIAEDFGWAEHHPMVEAYKAYHEMPYDRPTWDVIATYYVLPHEPSSLTLSIPGRITVDEQGFIFFTPDKAGQHRYITASDRQAGMILGYFLRALPERPLRYMR
>NZ_AP019739.1|WP_026075114.1|2547792_2549154_-|MFS-transporter
MQSFTPEVQKRFKYWQMRTLIATMIGYALFYFVRKNFSLAMPGLEADLGISKTSLGIFLTLNGLVYGLSRFVNGILADRLNARFFMATGLALCALANFAFGFGVDVSEWITGESSGSQFNNTLILFMGVMWVVNGMLQGTGFPPCARLLTHWIPPKELATKMSVWNTSHSIGAGLVVILCGYIMSHMGTGDAHVGAWRWCFWIPAGISFAGAIGLFISLRDTPTSVGLPELPGTESKKSGDAPSAADKAFLRRKVFGNPLIWILAFANFFVYIVRFSVLDWGPTLLSQSKGVSMSHAGWLVAMFEIAGIVGMLVAGWATDKFLGGRAHRTCVFCMAGAALFIFLFWQLPVGAPLWLTFLFLMMAGFCIYGPQALIGIAAAQQATKKAAATANGFTGLFGYASTIVSGAGLGYLAQHYGWNHAYIAMIAMALVGMAVFLLMWGAGRDGYETDAE
>NZ_AP019739.1|WP_026075115.1|2549528_2550299_+|DeoR/GlpR-transcriptional-regulator
MTLAERHDFIMDLLQQQGSVSVAALAERLKVSEVTIRKDLTLLEEKKMLYRAHGSAILINPYINDRPVNEKEKHNAAEKRAIGIRAASLVTPDDSILIASGTTMLFLAREIKAQGRLTVITSAVNIVPILVRDHNVDVVQLGGMVRNTSVSAVGVYAERMLQDFSCSKLYLGVDGIDLEYGLSTTNLMEAGLNRAMIRTAQKTIVLADSSKFGRRGFSKICDLSDVDQIITDSNVSPHTLAQLRSQGIEVTVVEAV
>NZ_AP019739.1|WP_141419205.1|2550538_2552794_+|sodium:proton-antiporter
MSAIAPLISDLAIILVAAGCSTLVFKGLRQPVILGYIVAGVLAGPSVSFIPTVSDASSIRVWADIGVIFLLFAMGLEFSFRKLLSVGGTAVTAAVTIVAGMMFVGYGTGMSLGFSHMSSIFLGGMLSMSSTAIVFKAFDDMGLRGQRFTGVVLGILVVEDLVGVVLMVLLSTLAVSKQFEGAEMLGSILKLGAFLIFWSLLGIYLIPTLLKRLQRLLNDETLLIVTLGLCLGMVMIAVKAGFSAALGAFVMGSLLAETVAAERITRLVEPVKNLFGAIFFVSVGMMIEPALLVRYAGPIVLLTVVVLAGQATFATLGVLVSGQPLRVAVQSGFSLTQVGEFAFIIATLGTTLHVTDDYLYPVIVAVSVVTTFLTPYMMRAADPACDYLERHLPAKWQRSLARYASGAGPESRHNTWLRLLRRMMLPGALYLVFCIFAEAAFLRYAAPWIEARIPGRTGAAVSLAAILAVLAPILLVVLRQGNRSPEFRQLWNDSKFNRGPLVSLILIKCLLCIGILMTVVASLFDTASGMGFAVSLALLTGIVFSKRLRRRSFEMEERLRENFGGDDTADAERPLNEGQLPFEQLHMAEFGVAAESIVAGRTLREIDFRRRYGVTVVAIRRGERRLQLPDGHTMLFPYDRLTVVGTDEEFRIFHRVLDEQRSERKRRREEKTATALRIGSYTLPARSALDGTTLGEAEVRRRASALVLGIERPEGPVTNPSAGERLRAGDVVWAVGDPQRMKPFFEAVRQE
>NZ_AP019739.1|WP_141419206.1|2552812_2553472_-|HAD-hydrolase-like-protein
MKTTYTHLLFDLDGTLTDPMEGITRSVQYSLRHFGIEVTDLRSLTPFIGPPLAESFREFYGFDDGRIPEAIRLMREYFSERGWRENRLYDGMPQLLERLCASGLTLAVATSKPAVFARRILDHFDLARYFAFVGGAELDGSRQAKADVIAHVLQGLGGVDPATCLMIGDRRHDVAGAAAAGMDSCGVLWGYGSRAELTGAGATRIAADLGELERIVTGR
>NZ_AP019739.1|WP_141419207.1|2553748_2554252_-|GNAT-family-N-acetyltransferase
MVILPATEADLQAVIELVAQGRAALARQGVDQWQDGYPSPETIRRDLLCGDGRIVRIDGAAAAYAAFVFDGEPAYDRIEEGGWAAEGPYVAVHRLVVGERFVRRGVAAALLREAAREALVRGIRSFRIDTHPDNGPMRALLVREGFACQGKVRYEAVRLAYEKPILG

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Crispr_ID: NZ_AP019739_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_17

2570587-2570696

Orphan

Consensus_repeat	Method
CCGCAAACTCCGTTTGCTTTTGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_17

>merge|NZ_AP019739|17|2570587-2570696|CRISPRCasFinder
CCGCAAACTCCGTTTGCTTTTGCCCGCGGCTTGTGCACTTTGCGGAAGACGAGCTTCCGCTTAGATAGGCGGCGCCTCGGCAAAGCCGCAAACTTCGTTTGCTTTTGCCC

>NZ_AP019739|17|16|2570587-2570696|CRISPRCasFinder
CCGCAAACTCCGTTTGCTTTTGCCC	GCGGCTTGTGCACTTTGCGGAAGACGAGCTTCCGCTTAGATAGGCGGCGCCTCGGCAAAG
CCGCAAACTTCGTTTGCTTTTGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019131500.1\|2579746_2580637_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_AP019739.1\|WP_019131491.1\|2567889_2569077_-\|elongation-factor-Tu	unknown	unknown	gnl\|CDD\|183708
NZ_AP019739.1\|WP_141412241.1\|2581086_2582295_+\|L-serine-ammonia-lyase	unknown	unknown	gnl\|CDD\|273233
NZ_AP019739.1\|WP_141412234.1\|2570720_2571272_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|182270
NZ_AP019739.1\|WP_141412239.1\|2576931_2578185_-\|L-rhamnose-isomerase	unknown	unknown	gnl\|CDD\|179217
NZ_AP019739.1\|WP_019131486.1\|2565268_2565790_-\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_AP019739.1\|WP_141419212.1\|2578211_2579636_-\|rhamnulokinase	unknown	unknown	gnl\|CDD\|198349
NZ_AP019739.1\|WP_019131487.1\|2565808_2566507_-\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071
NZ_AP019739.1\|WP_141412235.1\|2571312_2571831_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240049
NZ_AP019739.1\|WP_019131483.1\|2556449_2560712_-\|DNA-directed-RNA-polymerase-subunit-beta'	unknown	unknown	gnl\|CDD\|234794
NZ_AP019739.1\|WP_141419211.1\|2573936_2574734_-\|rhamnulose-1-phosphate-aldolase	unknown	unknown	gnl\|CDD\|179615
NZ_AP019739.1\|WP_141419210.1\|2571807_2573691_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|379140
NZ_AP019739.1\|WP_019131488.1\|2566513_2566954_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_AP019739.1\|WP_019131485.1\|2564852_2565230_-\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_AP019739.1\|WP_026075119.1\|2566970_2567531_-\|transcription-termination/antitermination-factor-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_AP019739.1\|WP_162502210.1\|2569654_2570053_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141412232.1\|2560747_2564608_-\|DNA-directed-RNA-polymerase-subunit-beta	unknown	unknown	gnl\|CDD\|234749
NZ_AP019739.1\|WP_019131496.1\|2574742_2575771_-\|L-rhamnose/proton-symporter-RhaT	unknown	unknown	gnl\|CDD\|237401
NZ_AP019739.1\|WP_019131490.1\|2567553_2567751_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|376355
NZ_AP019739.1\|WP_141412238.1\|2575772_2576927_-\|lactaldehyde-reductase	unknown	unknown	gnl\|CDD\|182595

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_019131500.1\|2579746_2580637_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.27365e-23
NZ_AP019739.1\|WP_019131491.1\|2567889_2569077_-\|elongation-factor-Tu	gnl\|CDD\|183708	PRK12735, PRK12735, elongation factor Tu; Reviewed.	0
NZ_AP019739.1\|WP_141412241.1\|2581086_2582295_+\|L-serine-ammonia-lyase	gnl\|CDD\|273233	TIGR00720, hypothetical_protein_NEICINOT_00681, L-serine dehydratase, iron-sulfur-dependent, single chain form. This enzyme is also called serine deaminase and L-serine dehydratase 1. L-serine ammonia-lyase converts serine into pyruvate in the gluconeogenesis pathway from serine. This enzyme is comprised of a single chain in Escherichia coli, Mycobacterium tuberculosis, and several other species, but has separate alpha and beta chains in Bacillus subtilis and related species. The beta and alpha chains are homologous to the N-terminal and C-terminal regions, respectively, but are rather deeply branched in a UPGMA tree. This enzyme requires iron and dithiothreitol for activation in vitro, and is a predicted 4Fe-4S protein. Escherichia coli Pseudomonas aeruginosa have two copies of this protein. [Energy metabolism, Amino acids and amines, Energy metabolism, Glycolysis/gluconeogenesis].	5.59442e-143
NZ_AP019739.1\|WP_141412234.1\|2570720_2571272_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|182270	PRK10151, PRK10151, 50S ribosomal protein L7/L12-serine acetyltransferase.	9.28219e-26
NZ_AP019739.1\|WP_141412239.1\|2576931_2578185_-\|L-rhamnose-isomerase	gnl\|CDD\|179217	PRK01076, PRK01076, L-rhamnose isomerase; Provisional.	0
NZ_AP019739.1\|WP_019131487.1\|2565808_2566507_-\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.04238e-142
NZ_AP019739.1\|WP_141419212.1\|2578211_2579636_-\|rhamnulokinase	gnl\|CDD\|198349	cd07771, FGGY_RhuK, L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is predominantly composed of bacterial L-rhamnulose kinases (RhuK, also known as rhamnulokinase; EC 2.7.1.5), which are encoded by the rhaB gene and catalyze the ATP-dependent phosphorylation of L-rhamnulose to produce L-rhamnulose-1-phosphate and ADP. Some uncharacterized homologous sequences are also included in this subfamily. The prototypical member of this subfamily is Escherichia coli RhuK, which exists as a monomer composed of two large domains. The ATP binding site is located in the cleft between the two domains. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of divalent Mg2+ or Mn2+ is required for catalysis. Although an intramolecular disulfide bridge is present in Rhuk, disulfide formation is not important to the regulation of RhuK enzymatic activity. Members of this subfamily belong to the FGGY family of carbohydrate kinases.	0
NZ_AP019739.1\|WP_019131486.1\|2565268_2565790_-\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	4.14102e-41
NZ_AP019739.1\|WP_019131483.1\|2556449_2560712_-\|DNA-directed-RNA-polymerase-subunit-beta'	gnl\|CDD\|234794	PRK00566, PRK00566, DNA-directed RNA polymerase subunit beta'; Provisional.	0
NZ_AP019739.1\|WP_141419211.1\|2573936_2574734_-\|rhamnulose-1-phosphate-aldolase	gnl\|CDD\|179615	PRK03634, PRK03634, rhamnulose-1-phosphate aldolase; Provisional.	7.12732e-110
NZ_AP019739.1\|WP_141419210.1\|2571807_2573691_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	5.0497e-29
NZ_AP019739.1\|WP_019131488.1\|2566513_2566954_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	2.55538e-89
NZ_AP019739.1\|WP_019131485.1\|2564852_2565230_-\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	2.50727e-36
NZ_AP019739.1\|WP_026075119.1\|2566970_2567531_-\|transcription-termination/antitermination-factor-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	2.72207e-58
NZ_AP019739.1\|WP_141412235.1\|2571312_2571831_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240049	cd04693, Nudix_Hydrolase_34, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.35594e-40
NZ_AP019739.1\|WP_141412232.1\|2560747_2564608_-\|DNA-directed-RNA-polymerase-subunit-beta	gnl\|CDD\|234749	PRK00405, rpoB, DNA-directed RNA polymerase subunit beta; Reviewed.	0
NZ_AP019739.1\|WP_019131496.1\|2574742_2575771_-\|L-rhamnose/proton-symporter-RhaT	gnl\|CDD\|237401	PRK13499, PRK13499, L-rhamnose/proton symporter RhaT.	1.73411e-123
NZ_AP019739.1\|WP_019131490.1\|2567553_2567751_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|376355	pfam00584, SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.	3.19451e-10
NZ_AP019739.1\|WP_141412238.1\|2575772_2576927_-\|lactaldehyde-reductase	gnl\|CDD\|182595	PRK10624, PRK10624, L-1,2-propanediol oxidoreductase; Provisional.	0

>NZ_AP019739.1|WP_162502210.1|2569654_2570053_-|hypothetical-protein
MRLKRYADKLAPAFSPAHPPPVLLPAFSQGGSCGALRATIKRMSPFIVCAARNHDHLVAFRFGRPAIFRRDGGCLPGQVKTHPLFRIGCAERGAILPVRVPEVVKTIYFLKKRGRLFFNSQNYSIFALDFAE
>NZ_AP019739.1|WP_019131491.1|2567889_2569077_-|elongation-factor-Tu
MAKEKFDRSKPHVNIGTIGHVDHGKTTLTAAITTVLAKAGLSELRSFDSIDNAPEEKERGITINTSHVEYQTANRHYAHVDCPGHADYVKNMVTGAAQMDGAILVVAATDGPMPQTNEHVLLARQVNVPKIVVFLNKCDMVDDPEMLDLVEMEVRDLLNKYEYDGDNAPIIRGSALGALNGEPKWEEKVMELMNAVDEYIPLPLRENEKPFLMPVEDVFSITGRGTVVTGRIETGVIKVGDPVEIIGLEEKVLTSTCTGVEMFRKLLDEGEAGDNVGLLMRGIDKKEVKRGMVVAKPGSITPHTKFEAEVYILKKEEGGRHTPFHNKYRPQFYLRTMDVTGEIALPEGVDMVMPGDHVTITVTLIYPVALNEGLRFAIREGGRTVGAGQIIKILE
>NZ_AP019739.1|WP_019131490.1|2567553_2567751_-|preprotein-translocase-subunit-SecE
MLNYIKESYKELVEKVSWPTFAQLQSSTIVVMVASLIFALVVLVMDISFENLMKGIYSFLGNIGH
>NZ_AP019739.1|WP_026075119.1|2566970_2567531_-|transcription-termination/antitermination-factor-NusG
MSEIKKQWYVIRAVGGKENKVKEYIESEIRHNHLEDYISQILIPTEKVYTIRNGKKISKEKVSYPGYVLIEAAFVGQIPIIIRNTPNVLGFLGDTKEESRKMIATPLRPQEVSRILGRVDELSEMEEENEVPFFVGETVKVTDGPFSSFQGTIEAVDNERKKLTVSVKIFGRKTPMELSFTQVEKE
>NZ_AP019739.1|WP_019131488.1|2566513_2566954_-|50S-ribosomal-protein-L11
MAKEVAAFIKLQIKGGAANPSPPVGPALGSKGVNIMDFCKQFNARTQDKAGKVLPVIITVYSDKSFDFVVKQPPVAIQLKEAAKVKSGSAQPNRDKVGEVTWEQIEAIARDKMPDLNCFTVEAAMRMVAGTARSMGINVKGEFPKK
>NZ_AP019739.1|WP_019131487.1|2565808_2566507_-|50S-ribosomal-protein-L1
MSKLTKNQKNAYAKVEPNKAYKLAEAAALLKEITFTKFDASVDIDVRLGVDPRKANQMVRGVVTLPHGTGKTVRVLVLCTPEKEEEAKAAGADYVGLDEYVEKIKGGWTDVDVIITTPNVMGKVGALGRILGPRGLMPNPKTGTVTMDVAKAVSEVKAGKIDFKVDKFGIVHTSIGKVSFSPEQIVDNANEFLSMIMKLKPSAAKGSYVKSIYLSSTMSPGLQIDAKSVETK
>NZ_AP019739.1|WP_019131486.1|2565268_2565790_-|50S-ribosomal-protein-L10
MTKEEKAVVINNLAEQLNEYPHFYLTDIETLNAEQTAQLRRKCFENEIKLVVVKNTLFGKALEKAEKADADLMKVLEGSTSVMFATTAKAPAVVIKEFRKKSEKPVLKAAFVEECVYVGDNQLDALCNIKSKEELIGEIVSLLQSPAKNVISALQANAGQKIAGLVKTLEERN
>NZ_AP019739.1|WP_019131485.1|2564852_2565230_-|50S-ribosomal-protein-L7/L12
MADVKKLAEELVNLTVKEVNELATVLKEEYGIEPAAAAVAVAAPAAGAGEAAAAEKTSFDVILKNAGQSKLQVIKVVKEIAGLSLGDAKALVDGAPKAVKEGVSKEEAESIKGQLEEAGAEVEVK
>NZ_AP019739.1|WP_141412232.1|2560747_2564608_-|DNA-directed-RNA-polymerase-subunit-beta
MSTNTTQQRISFSTVKNRVPYPDLLEVQLKSFRDFFQMDTTAENRKNEGLYKVFQENFPITDTRNNFVLEFIDYYVDPPRYSIEECLERGLTYSVPLKAKLKLYCTDTEHEDFGVVVQDVYFGTIPYMTERGTFVINGAERVIVSQLHRSPGVFFGQSMHTNGTKLYSARIIPFKGSWIEFATDINNVMYAYIDRKKKLPVTTLLRAIGFEADQQILEIFDLADEVKVTKANLKKAVGRMLAARVLSTWVEDFVDEDTGEVVSIERNNVIVDRETVLQEEHIEQIIESGAKTILLHKENPSGIDFSIIYNTLQKDPCNSEKEAVVYIYRQLRASEPPDEATARDVIEKLFFSDKRYDLGDVGRFRINKKLGLEIDPEIRTLTREDIIAIIKYLIQLINSRAEVDDIDHLSNRRVRTVGEQLSNQFSVGFVRMARTIRERMNVRDNEVFTPVDLINAKTLSSVINSFFGTSQLSQFMDQINPLAEITHKRRLSALGPGGLSRDRAGFEVRDVHYTHYGRLCPIESPEGPNIGLISSLCVYAKISDMGFIETPYRSVNDGVIDLDNSHIRYYSAEEEEGKVVAQSNVPIDDEGHFLQPNRIKARKGADFPVVTDKEVDLMDVAPNQIASIAASLIPFLEHDDANRALMGSNMMRQAVPLVTCEAPIVGTGIEKDMISDSRIQIVAEGDGEVVFADATQIRIKYERTPDEVVCSFAPEVTTYELPRYRRTNQNTSITLKPVVLTGDRVTKGQILTEGYSTQGGELALGRNLKVAYMPWKGYNFEDAIVISERIQREDIFTSVHVDEYIMEVRDTKRGVEELTSDIPNVSEDATKDLDANGIIRIGANVHPGDILIGKITPKGESDPSPEEKLLRAIFGDKAGDVKDASLKAQPSLHGVVIDTKLYSRAGKEAKKSKAAEKAMLEKLDEKFAAEIADLTKLLVQKLWSLVQGKTTTGVTDYFGAELYAAGTKFTQKMLEELSRQTTDERTGVPTGFLNLGSCGWTSDEHVNALIEATINNYTIEWKKADAAIKREKYNLTNGDELPQTGVIQMAKVYIAKKRKLKVGDKMAGRHGNKGIVARIVRDEDMPFLEDGTIVDICLNPLGVPSRMNLGQIYEAVLGWAGRELGVKFATPIFDGASLDQINEYTAEAGIPRSGRTYLYNGETGERFDQPATVGVTYMLKLGHMIDDKMHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEGFGAANILQEILTIKSDDVTGRAKAYEAIVKGDNLPKPGIPEAMNVLLHELRGLALSVKLE
>NZ_AP019739.1|WP_019131483.1|2556449_2560712_-|DNA-directed-RNA-polymerase-subunit-beta'
MPFNKDNKPAGGYNRISIGLASPEEILAQSSGEVLKPETINYRTYKPERDGLFCERIFGPVKDYECHCGKYKRIRYKGIVCDRCGVEVTEKKVRRERMGHISLVVPVVHIWYFRSLPSKIGYLLGIPSKKLEAIIYYERYVVINPGAAAEQGIERLQTLAEKEYLDVLAALPKGNQSLDDSDPNKFVAQMGAEAIYTLLQQVDLDSMSYALRHKASTETSQQRKSEALKCLNVIESFRASNGLNKPEWMVLKVIPVIPPELRPLVPLDGGRFATSDLNDLYRRVIIRNNRLKRLIEIKAPEVILRNEKRMLQEAVDSLFDNSRKSNAVKNESNRPLKSLSDSLKGKQGRFRQNLLGKRVDYSARSVIVVGPELKMHEMGIPKDMAAELYKPFIIRKLIERGIVKTVKSAKKIIDRKDPVIWGILENVIKGHPVLMNRAPTLHRLGIQAFQPKLIEGKAMQLHPLACTAFNADFDGDQMAVHLPLGNAAILEAQLLMLGSHNVLNPANGAPITVPSQDMVLGLYYITKPRKGVKGEGLVFYGPEEAIIAYNEKRADLHAEVKCMVNDIDENGQRVSVLKDTTIGRILFNQVVPEEVGYINTVLTKKSLRDIIAVVMKKAGADKVAAFLDDIKNMGYRMAFQGGLSFNLDAVIIPEEKEKLVQEGYDRSDAIMEDYNMGLITNNERYNQIIDVWTNINTKLTKVVIDTLVKDQDGFNPVYMMLDSGARGSKEQIRQLSGMRGLMAKPQKSGVEGGQQVIENPILSNFKEGLSVLEYFVSTHGARKGLADTALKTADAGYLTRRLVDVAQDVIINEEDCGTLRGLTATAIKRNDDVVQTLYDRILGRTALNDVIHPLTGEVICKAGQEITEDIAEAIEKSPLESVEIRSVLTCEARHGVCAKCYGRNLATARMVQKGEVVGVIAAQSIGEPGTQLTLRTFHVGGVAGGSVVETNVVSKYEGRLEIEELRTIKGKNAQGEATNVVISRQSEIRIVDPKTEIVLYTHPLPYGATLFMTDGAEVKKGDLICEWDPYNAVIISEFEGKASYENVIEGVTYREERDEQTGLSEKVVIESKDKTKNPVIKIINREGEEVKSYNLPVSAHVVVKDNAKIHAGDILIKIPRAVGKSGGDITGGLPRVTELFEARNPSNPAIVSEIDGEVSFGKIKRGNREIVITSKQGDVKRYLVPLSRQIIVQENDYVKAGSPLSDGAITPSDILRILGPTKVQEYIVNEVQEVYRMQGVKINDKHFEVIVRQMMSKVQIEDPGDTRFFEDQIVDKWEFMDVNDALYDKVVVTDAGDSTSVQPGQIISLRKLRDENSSLKRKDMRQVQVRDIVPATSNQVLQGITRAALQTSSFISAASFQETTKVLNEAAIQGKVDPLENLKENVICGHLIPGGTGLREYDDLLVGLKSDVENLTAAAQ
>NZ_AP019739.1|WP_141412234.1|2570720_2571272_+|GNAT-family-N-acetyltransferase
MKTIPILPGIALHELRTADAADIFAAIDGERAYLGRWLPFVQFTRNEEDSLRFVRSVLEASYRETVFTIRDGERFIGLIGFKSTDPLARTTEIGYWLREAWQGRGIVTTAVRALCRMAREELAMRCVAIKCATGNGPSNRIPQRLGFTLDHVEHRAELLEDGRYTDANVYLLNLADRNTSVRP
>NZ_AP019739.1|WP_141412235.1|2571312_2571831_+|NUDIX-domain-containing-protein
MNRDNSSELFPVVDETGRVVGCATRGECHDGRRLLHPVVHLHLFNSRGELYLQKRPLWKDIQPGRWDTAVGGHVDYGETPDEALRREVREELGVTEFTPERLTQYIFDSVRERELVYVNRTVYDGPVTPSDETDGGRFWTIGEILRTLGTGLFTPNFESEFRRVFLTDDGIA
>NZ_AP019739.1|WP_141419210.1|2571807_2573691_-|PQQ-binding-like-beta-propeller-repeat-protein
MKQKIALLLAAALLLCSGVLARRAPRHVAPRAAELNFAFLTDVHVTPRGESDSLLRAAVAEINASAVDFVLVTGDLCNMGSDAELHCVHGILKRLRKPWFAVPGNHETTWSESACTTFGRLFGNDGRLAFRAGGYLFVGFTAGPYMKMADGSVRREDLQWVEEQMRAARPGERIVTFCHYPLTNDMTNRTAVTQLLRRYDVRFDLCGHYHTLRLCNFDSIPGLMGRSLIPKNRMQEPAAGYNLVRVWGDSVALYEKRLGEAPRLSFAIPQGNSAALAALPCDPQPAPITYERTGAALVVEDEASIYTGVAVVGDTIFYGTSLGVLKAYDVKNRREVWRRQFGNAVYSTPLAAGGVVVAGDAAGAVWGLDAATGRRLWRIAAKTPVIGDGLVAGDWLYMGLGSGSMAKIELRTGRIAWEFRFGEGQPQGRPAVAGGRVVFGAWDTNLYCLDEATGERLWSWNNGSPQKLYSPGHIVPRIVGGRVFIVAPDRCMTALDLATGREIWRVKRRKVRETTGVSADGSAVYAKTMDGELLAVATDADRYTELWTVDAGWGYDHNPCPVEVREGVAYMANRTGCVASVSGDGRLFWAEKFASSAANDFFVDADNRLWVTFIEGKIFCLGDPVVR
>NZ_AP019739.1|WP_141419211.1|2573936_2574734_-|rhamnulose-1-phosphate-aldolase
MKLIDNESLDRQIGVVAEVAGYLWERGWAERNGGNISVNVTGLCADAVCELPALDGPYLLPKPVPHIAGGCFLVTGTGRRMRYVASQPLANVALIRVAADGASYEIVADEPVRPTSELPAHLSVHDYLVGAGRPERAVVHTHPIELVAMTHNPEFLGKDVLTRLLWSMIPETRAFCPKGLGIVPYTLPGSQELADRTIALLDDYDVVMWTKHGALAIGTDLIEAFDQIDVLSKSAKIYESARSMGFVPTGMSDAEMQELKEVFGL
>NZ_AP019739.1|WP_019131496.1|2574742_2575771_-|L-rhamnose/proton-symporter-RhaT
MEILIGLLIIAVGSFGQSSSYVPIRKVRDWSWESFWLVQGIFAWIVFPWLGASLALPEGVTLGALWAAGGAWQSVFYGVLWGVGGLTFGLSMRYLGVALGQSIALGTCAAFGTLFPALLAGQNLFRGEGLALLLGVCITLAGIAVIGYAGSLRSRLLSDEERRAAVKDFALTKGLLVALLAGAMSACFSLGLESGAAIQAAAVAAGVKELFALNPVILLVTLGGFATNAAYCIFCNVKNRTGRDYFSVPAGVWVNNVLFCALAGVLWYSQFFGLGMGKSFFAEAPLMLAFSWSILMSLNVLFSNLWGILLHEWRGVDRRTAAVLVTGLLILIFSTVYPQLVK
>NZ_AP019739.1|WP_141412238.1|2575772_2576927_-|lactaldehyde-reductase
MYRIVLNETSYYGAGCRSVIAEEVRKRGFRKALLVTDKDLIRFGVAEKIERVLADAGIPYEIYSEIKANPTIRNVQQGVEAFKRSGADFMVALGGGSSIDTAKAVGIIVNNPEFADVRSLEGTAATKHRAVPTFAVPTTAGTAAEVTINYVITDEEAKRKMVCVDPNDIPMCAVIDCELMYSMPKGLTAATGMDALTHAVEGYLTPGAWTMSDMFELKAIELIARHLKNAVDDGSDETARAGMAEAQYIAGMGFSNVGLGIVHSMAHPLGAFYDTPHGVANATLLPYVMEYNAESPSRAKYLDIARAMGVKTDGMSVDEGVRAAVDAVKALSLSIRIPQRLHELGVREEDIPALAVAAFNDVCTGGNPRPTSVEEIERLYHIAY
>NZ_AP019739.1|WP_141412239.1|2576931_2578185_-|L-rhamnose-isomerase
MKTQLIEEAYRIARERYAAVGVDTDEALEKLQRVSLSLHCWQADDVTGFENRGGELTGGIQATGNYPGKARNVEELRADILKAASYIPGTHRLNLHEIYGEFGGEKVDRNEVEVKHFAGWIEWARAHGMKLDFNSTSFSHPKSGSLSLSNPDPEIREFWIEHTRRCRAIAEAMGEAQGDPCIMNLWVHDGSKDLTVNRMLYRELLRDSLDRIFEQKYDHMKDCIESKVFGIGLESYTVGSNDFYIGYGASRGKIVTLDTGHFHPTELVADKLSSLLLFTPEVMLHVSRPVRWDSDHVTIMNDDTLELCKEIVRCDALDRVHIGLDYFDASINRIGAYVIGSRATQKCMMQALLEPLAKLRAYEADGQGFERLALLEESKSLPWNAVWDMFCLKNDVPVGEEFIADVQRYEAEVTSKR
>NZ_AP019739.1|WP_141419212.1|2578211_2579636_-|rhamnulokinase
MQKNIIGVDLGATSGRVILARAGDDRLRMEELHRFPNRMREIDGRFYWDIHALYEEILRGLSVAGGRGERIDSIGIDTWGVDFACVDPDGDLLGLPRAYRDPYTDGVPEEFFRTVPRESVYAKTGIQVMNFNSLYQLYALNREHSPALAAAEHVLFMPDALSYLLTGEQVCEYTILSTSQLMNPRTRELDGELLRAAGVDASLFARRVMPGERVGVLRDEVARRTGLGRVEVFAVAGHDTASAIAAVPAADERFAYLSSGTWSLMGIELPAPVITEESCAMNFTNEGGVDGTTRFLKNITGMWLLEECRRIWAKEGRTYTYAEIMAMAAAAEPGRTRIDPDDEAFAHPADMPAAIRDWCRGRGKVPPADDAALVRCIFESLAARYGEVLGNLRGVAPFAIERLHVIGGGAQNDLLNQLTADACGIPVVAGPSEATAIGNVMVQARALGLVGSLARMRDYIRRSVEVREFLPRTK
>NZ_AP019739.1|WP_019131500.1|2579746_2580637_+|AraC-family-transcriptional-regulator
MGSFPQSIVHYLPVTDHDERWGIVCTTAGYQNVPPGSPYPLTQHPDSYSFTRSRGRVLGEYQLLYIVSGQGEFRSASSPAAPVKAGTVVMLFPDEWHTYAPDPETGWEEWWVGFRGENIDRRVAEGFFSPKTPLLHIGHSAGIVSCYQEIIRSAEEERKGFQQLVTGIVLHLLGSVLFKRDNLQYLDNPIVEKINRAREMMRRHIGDNLPPEEIARRLNIGYTWFRRTFRAYVGIAPAQYQLQLRHNKARELLTTTDRTVSEIAAELGFENVSQFSAFFRQREKITATQYRSKYGF
>NZ_AP019739.1|WP_141412241.1|2581086_2582295_+|L-serine-ammonia-lyase
MKSIKELYRIGTGPSSSHTMAPRRAAEQFLARHPEAAAFRVTLYGSLAATGRGHMTDRAIIDTLLPTAPVDIVWQAREFLPFHPNGMRFQALDTAGTPTDTWTVYSIGGGELAEEGVPPRQAEEIYEMNTLDEILAWCRRTGRTYWEYVEECESDDIWDYLAEIWQAMRESVERGLDHEGVLPGPLHLTRRAATYHVRASGYKQSLQSRGLVFAYALAVAEENASGGRIVTAPTCGSSGVVPAVLYHLQKSRGFSDARIYRALATAGLFGNVVKHNASISGAEVGCQGEVGVACAMAAAAANQLFGGSPSQIEYAAEMGLEHHLGMTCDPVCGLVQIPCIERNAYAAARALDANLYSAFTDGGHRVSFDRVVEVMKQTGHDLPSIYKETGEGGLAREYDPDK

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Crispr_ID: NZ_AP019739_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_18

2602821-2602942

Orphan

Consensus_repeat	Method
TGAACAAGTTCGGCTCTGCGCTCGGCTTAACGAAAACGTTGATTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_18

>merge|NZ_AP019739|18|2602821-2602942|CRISPRCasFinder
TGAACAAGTTCGGCTCTGCGCTCGGCTTAACGAAAACGTTGATTTTCTCTCTTCGTTTTCTCGCCTCGGCATAGCCTGAACAAGTTCGGCTCTGCGCTCGGCTTAACGAAAACGTTGGTTTT

>NZ_AP019739|18|17|2602821-2602942|CRISPRCasFinder
TGAACAAGTTCGGCTCTGCGCTCGGCTTAACGAAAACGTTGATTTT	CTCTCTTCGTTTTCTCGCCTCGGCATAGCC
TGAACAAGTTCGGCTCTGCGCTCGGCTTAACGAAAACGTTGGTTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_162502212.1\|2606169_2607705_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379837
NZ_AP019739.1\|WP_141419224.1\|2616421_2617753_-\|histidine-type-phosphatase	unknown	unknown	gnl\|CDD\|132717
NZ_AP019739.1\|WP_141419215.1\|2592817_2593741_-\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP019739.1\|WP_019131505.1\|2586038_2587367_-\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NZ_AP019739.1\|WP_162502211.1\|2594063_2594546_-\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_AP019739.1\|WP_141419222.1\|2612707_2614531_-\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419213.1\|2584553_2585966_-\|Ig-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|367056
NZ_AP019739.1\|WP_141419217.1\|2597240_2599034_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NZ_AP019739.1\|WP_019131514.1\|2599052_2602616_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_019131516.1\|2604006_2604576_-\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_AP019739.1\|WP_141419216.1\|2595862_2597215_-\|BACON-domain-containing-protein	unknown	unknown	gnl\|CDD\|271342
NZ_AP019739.1\|WP_141419220.1\|2607794_2609603_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NZ_AP019739.1\|WP_019131515.1\|2602980_2603916_-\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP019739.1\|WP_019131511.1\|2594915_2595797_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176524
NZ_AP019739.1\|WP_141419223.1\|2614757_2616425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379837
NZ_AP019739.1\|WP_141419221.1\|2609615_2612612_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_141419214.1\|2587397_2589191_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|369630
NZ_AP019739.1\|WP_141419225.1\|2617764_2618658_-\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|238572
NZ_AP019739.1\|WP_141419218.1\|2604882_2606052_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176524
NZ_AP019739.1\|WP_141419686.1\|2589209_2592725_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_162502212.1\|2606169_2607705_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|379837	pfam16370, MetallophosC, C terminal of Calcineurin-like phosphoesterase. This is the C-terminal of Calcineurin-like phosphoesterases. It is around 150 residues in length from various Bacteroides species. The function of this family is unknown.	1.09969e-39
NZ_AP019739.1\|WP_141419224.1\|2616421_2617753_-\|histidine-type-phosphatase	gnl\|CDD\|132717	cd07061, HP_HAP_like, Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction. Catalytic domain of HAP (histidine acid phosphatases) and phytases (myo-inositol hexakisphosphate phosphohydrolases). The conserved catalytic core of this domain contains a His residue which is phosphorylated in the reaction. Functions in this subgroup include roles in metabolism, signaling, or regulation, for example Escherichia coli glucose-1-phosphatase functions to scavenge glucose from glucose-1-phosphate and the signaling molecules inositol 1,3,4,5,6-pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) are in vivo substrates for eukaryotic multiple inositol polyphosphate phosphatase 1 (Minpp1). Phytases scavenge phosphate from extracellular sources and are added to animal feed while prostatic acid phosphatase (PAP) has been used for many years as a serum marker for prostate cancer. Recently PAP has been shown in mouse models to suppress pain by functioning as an ecto-5prime-nucleotidase. In vivo it dephosphorylates extracellular adenosine monophosphate (AMP) generating adenosine,and leading to the activation of A1-adenosine receptors in dorsal spinal cord.	2.55631e-14
NZ_AP019739.1\|WP_141419215.1\|2592817_2593741_-\|DUF4974-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	5.83732e-31
NZ_AP019739.1\|WP_019131505.1\|2586038_2587367_-\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	1.21858e-08
NZ_AP019739.1\|WP_162502211.1\|2594063_2594546_-\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	7.75652e-38
NZ_AP019739.1\|WP_141419213.1\|2584553_2585966_-\|Ig-like-domain-containing-protein	gnl\|CDD\|367056	pfam02368, Big_2, Bacterial Ig-like domain (group 2). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial and phage surface proteins such as intimins.	2.03002e-08
NZ_AP019739.1\|WP_141419217.1\|2597240_2599034_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.04043e-33
NZ_AP019739.1\|WP_019131514.1\|2599052_2602616_-\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_019131516.1\|2604006_2604576_-\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	7.98864e-52
NZ_AP019739.1\|WP_141419216.1\|2595862_2597215_-\|BACON-domain-containing-protein	gnl\|CDD\|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	1.09192e-07
NZ_AP019739.1\|WP_141419220.1\|2607794_2609603_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	1.24771e-50
NZ_AP019739.1\|WP_019131515.1\|2602980_2603916_-\|DUF4974-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	2.51261e-39
NZ_AP019739.1\|WP_019131511.1\|2594915_2595797_-\|hypothetical-protein	gnl\|CDD\|176524	cd08582, GDPD_like_2, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized bacterial glycerophosphodiester phosphodiesterase and similar proteins. They show high sequence similarity to Escherichia coli glycerophosphodiester phosphodiesterase, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	3.29004e-09
NZ_AP019739.1\|WP_141419223.1\|2614757_2616425_-\|hypothetical-protein	gnl\|CDD\|379837	pfam16370, MetallophosC, C terminal of Calcineurin-like phosphoesterase. This is the C-terminal of Calcineurin-like phosphoesterases. It is around 150 residues in length from various Bacteroides species. The function of this family is unknown.	8.08584e-22
NZ_AP019739.1\|WP_141419221.1\|2609615_2612612_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_141419214.1\|2587397_2589191_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	8.32343e-38
NZ_AP019739.1\|WP_141419225.1\|2617764_2618658_-\|carbohydrate-kinase	gnl\|CDD\|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	9.5026e-60
NZ_AP019739.1\|WP_141419218.1\|2604882_2606052_+\|hypothetical-protein	gnl\|CDD\|176524	cd08582, GDPD_like_2, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized bacterial glycerophosphodiester phosphodiesterase and similar proteins. They show high sequence similarity to Escherichia coli glycerophosphodiester phosphodiesterase, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	2.98099e-25
NZ_AP019739.1\|WP_141419686.1\|2589209_2592725_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0

>NZ_AP019739.1|WP_019131514.1|2599052_2602616_-|TonB-dependent-receptor
MKKICGRLTRILCTCAVFVSLTGAAYAQSAPVTLDRKKAPVREILNEIERQTDYLFVYSSEQVDFSVSVTAHDEPVQTVLRRIFEGTPIRFTLEGKHIVLRRQPQTAANAAAASPAKQTVTGTVTDTAGKPVVGATVLVKGGTVGTTTDVDGRFSLTIPAGSPLEVSFLGYARQEIATAGRTSLDIRLEEDAATLDEVVVVGYGTMKRRNLVGAVDQVDSRVIGDRSNGNLARSLQGELPGLNISFSDSKPSRSASFNVRGETSIGAGGNALVLIDGVEGSMDAINPQDVESVSVLKDASSTAVYGARGAFGVVLVTTKSPKRGAPEINYNGSVTFNRRTVIPDVITDGLTWVNWWKDSYNGYYNGSKSLLSHIDSTVPYSEAIYQELIRRQADPSLSRTTTLEGDSMFGWAYMESTDWLDLFYKDWNLSHEHNLSISGGNENADYYVSGRFYDMDGIYRVGDESYKKYDLRAKGSLKIRPWFKVTNNTSLAIIDQHEPKHSRNNFAVQRAINHAAMPLSPVKNPDGSWTTAAAISGYAAFSEGTSYRNNDYVYFRNKLSADIDIVKEVLKVQADYSYNYTTRKRIDVQNPVKYSKKPGVYLLESESAGASLSQVDYDTRYQAANAYLTYTPKLGADHDLTVLAGWNIEDQVYKTLTVSRTGFVTPNKPSFSLMNGVAENPTAGGNAWSYVGAFYRVNYGYKGKYLVEVSGRYDGSSKFPIHSKWGFFPSASVAWRISDEPWMGWSRRALDNAKIRLSAGSMGNGNVSPYSYTSEMTVSTADDIVLGGSYPSYTSVGSTVPVSLTWEKSTTYDVGLDLDFFNNRLSVSGDYYRRYTTDMYTASVALPAVYGTGSPKGNNAEMKTDGWELSLSWRDSFKLGGKPFDYSIKAMVWDSKSVITKYVNDTGSLGTVKGFIENGGSPSSYYVGMTVGEIWGYTVAGLFRDQADIDSSAIHDFVQASDKVTRPGQVKIADLDGNGFIDPGNFAVDDHGDLRIIGNQSPRYRYGVNLSARWNGIGLSVFLQGVGARDWYPGSDAGMFWGKYGRPFFALIPSIHNYTDDMYSAERNNWDTAYWPRMTTYQSNGTKNWTRLLEIPNTRYIQSAAYLRVKNIQLDYSFPKHICSAIRLQGLKIYVNAENLFTFTPLHKYAPNFDPEGLSYDSDFASAADGYTYPILKSVTVGVNITF
>NZ_AP019739.1|WP_141419217.1|2597240_2599034_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKNHIAILIGALALCSCEDYLTQENPNKIESKYYFTDESSLEIYTNGFIRSFATAIKSFVDGDKNADTHSWDGQAAYFMDNYSADDATNWTTSNWSQLRSINYYLDNMRNAVASDAILDHYEGVGRFFRALFYIDKVQTFGAVPWYDTSIDATDQEALFKDRDNREFVASRILEDLDYACTYCLTSDKYRVRASYIHRYVALALKARFCLYEGTMRKYHAVDPSTGRAWTKDESRFYLGECVKACEAIMGDGVYKLTDDPAKRQTQYRDMFTNADACGVYTDEFIWARDYDIDLKVTYAINNYMVNPQHANYAFTRQFIDTYLMTDGTPFTSKYPDYDDLDLVAECTDRDYRLAQTIRTPGFTRDGGTTQWAPDVKFSKTGYQPIKWLTDDSSKDTNVAAIASDVPLIRYAEVLLAYAEAKAELGEMSEEVWNKTIKPLRERAGVKSIYPTAADPYMVEYFQNQVTDPFILEVRRERGIELTMENSRYQDIIRWHQGELFARPWKGVCISAVDTPLDLNADGTPETIVTANPKLQSTLNILMIDGASEAGHKLSRGTSGNILPSTALERKWQDYKYVKPIPTTARQENPNLTQNPKW
>NZ_AP019739.1|WP_141419216.1|2595862_2597215_-|BACON-domain-containing-protein
MKTIDKLSFVPLLALLLFAGSCEKDGGVFMRENDAIACDCTEQSISQNVLCDGEWVADCGDVGWIAITPERGSGNGKDYGFFTLNIQYNSGAERTATVHLVYDGAAYPITVTQGACEFAYGEPRVEGNLFRNIESTATLRLPYVCASGRESVEISCTITGVAADGLSVTKQVYTGFAKGSGELTIPVEGAATRAGAVAFELFADGVSVGSCRANVISDPDAVPEGLPVGWNFYALGMTGTAPRGSEWDYSWTTDAIHPATDTNPLDAHRLLPTAGNENAYLTASGVVSDNGNYTFNPGIQIKGLMENDYFLFVIPVRNIKAEHKLSVEASMGAAGSGPGYYALEYSADNKTWMLAEGSTLMEVFGTSAQVHYYVPKENTSGDRKTYDKSTDKGYRKYVFPLTGMETIYEGNLYLRLRICMDRRANGSESTNTIASAWADLKGFEVALVEE
>NZ_AP019739.1|WP_019131511.1|2594915_2595797_-|hypothetical-protein
MRSVKKILWSCAVLAVVCGCTKLETPPNKNQPSGDGTGVYKVVAHRGGYQECARPDCSISSLKYAIMLRCFASECDIVLTGDNDVLVAHPQSGYLVNGLEPFDHTVAEIRAAGTLANGEPVPTLRDFIRVLQDPELNPHGMRLWLDVKRLTKNGEEIDVNHSINACYRACEIIKEMKAQSLCEFLIPTGGSIFDVVRDKVIDEYRINLAWMTCTHPDNYGKAWAQLSYDKIFGDNTAYGPMDYISAGVPLSVYNVDDDETMDAVIPYYPKLKAIFTNYPSKLIQKLRAQGYAD
>NZ_AP019739.1|WP_162502211.1|2594063_2594546_-|RNA-polymerase-sigma-70-factor
MFTLCYDRYHRGIYLFVLKYVRCEALAEDIVQEVFFRLWCNRRGLREEGNLAALLYAMAKNLTVNAIRKHKIVETGNVRYYDLHEGRQEPAGESDSDETMRRLRLAVGELPARQRTIFNLKIYESRSNQEIADMLNVSVNTVKVHYARTMKHLCQRLKKN
>NZ_AP019739.1|WP_141419215.1|2592817_2593741_-|DUF4974-domain-containing-protein
MGRKSFEKAGGLSPERIRQMDADIAQALSSERETGGVDVPSLKLLDAIDAKIRRRNRRSVAGAFAAVCLPLVALCLTAFAELYGWGHEPVMRSVQVPAGEHLRVLLADGSAVTLNACSELRYPERFARRRREVRLVRGEAFFEVAHDASAPFTVETDDVSVEVLGTKFNVNAYDKEVTTVYLKEGKVRLTERVTGRQNRYLMAPDEMLAVDRNARTCRAVRPAGKSAPEAWLHNNYAFTNAPLEDVVEFLERHYAVEIEVADARILQYSYTMEFYNETIDEVLSVMSQITPIRYSRVNDRITVRAAR
>NZ_AP019739.1|WP_141419686.1|2589209_2592725_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MLTLACLFALSGLSAQNVTLRFERAKLKTVMDEITRQCDLSFAYSREVVDADRIVSIDLKDAPIDAALQSLFPSGNGIDYAIKNRKILLSAGKQSLHVDTVVSGRVADDQNRPLVGATVVVAGTSQGTTTDLDGNFSLRVNAVDPVLKVDYLGYEPQELRVSPSQTTFDIRLALSSKAIDDVVVVGYGTVKRRDLVGAVDQVDRKVIEDRSTGTLARALQGQLPGLNITFTDSKPTRGASVNVRGSGSIGAGGSTLVLIDGVEGSINAINPQDVESVSVLKDASSSAVYGARGAFGVVLITTKSAKKGTPVINYNGSVTINRRTVTPDVVTDGLTWINWWKDCYNGYYNGSKALLNHVDSTIPYTETIYQELIRRSQDPSLARTTALSGHDQFGWAYYDSTDWHSLFYKDYNWSTEHNLSISGGGDQADYYISGRFYDMDGIYKVGNDSYKKYDVRAKGTLKVRPWLRLTNNMSVSVIDAYEPKHQKNNSQIPRLINHTAMPLSPVKNPDGTWTAAAAKSGYAAFSEGTSWRTNDYVYLRNKFDVNIDLVKDVLTASVDYSYNYTNRKRMDAQTVIEYSKKPGEILYESEAAGSNLQSVEYQTRYQSANAYLNWSPKLGDDHTFKALAGWNIEKQKYETLTIKREGFVTASKPSFGLMNGTTTDPTVGGYIWSYVGAFFRLNYGYKGKYLAEVSGRYDGSSKFPTNSKWGFFPSASVAWRVSEEPWMKWSEEWLDNFKIRLSAGSMGNGNVDPYSYTSEMTVVTASDIVLGGGLPSYTTVGSTVPVSLTWEKSTTYDLGLDLDFLNNRLSFSGDYYRRYTTDMYTPSISLPSVYGTTSPKGNNAELRTTGWELSLTWRDSFKLGGKPFDYSIKAMVWDNRTVVTKYENATRSLGTLKGYIQNGGSPSDFYEGMELGEMWGYTVAGLFRDQADIDSSATHDFTQASDKVTRPGQVKIADLDHNGNIDPGAFTADDHGDLSIIGNINPHYMFGVNLAANWNGIGLSVFLQGVMKRDWYPSPDSGYFWGKYARPFMWVLGIHNYTDDMYSEEKNNWDTAYWPRMTTYQSNSSYSWTKLLEIPNTRYKQNAAYLRVKNIQVDYTFPKALCQKIRLGGLKIYLSGENLFTFTPLHKYAPNFDPEALGYDTDFSSTAGDGYTYPVLKSVTLGVNITF
>NZ_AP019739.1|WP_141419214.1|2587397_2589191_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKKYIAILFACVSFCACEDFLTQENPNKIESEYYFKDESSLEIYANGLTRSFATGIKNFVNGDKNADTHAWDGAAAYFKDNYSASDASNWGTSNWSQLRSINFYLDNMRKGDAPEAVLNHYEGVGRFFRALFYYAKVRTFGAVPWYEKSIEATDQEALFKDRDNREYVCRKILADLDYACTYCSTAASYRNQASYIHRYVALALKARFCLYEGTMRKYHTLDPSTGRPWQSDESAMYLGECVKACEAIIGDGVYHLTDNAADRRTQYRAMFIESNATTAYANEIIWARNYDSELNVTHYMNSYFINQQYANYAFTRQFINTYLMTDGTPFTDKYPDYDSVDFTTECSGRDYRLAQTIRTPGFTRDGGTTQWAPDVTFSKTGYQPIKWLTDDSSKDTNTSKCDNDVPLMRYAEVLLNYAEAKAELNEMSEEVWNKTIKPLRERAGVTSIYPTTADPYMVEYFQNQVTDPFILEVRRERGIELTMENVRYDDIIRWHQGELFARPWKGIWIAASETPIDLNGDGVNDCIVTSDPNNKSPLKILFIDGASEAGHKLSQGTSGNILPATAIERKWHDYKYVKPIPTTALQENPNLTQNPEW
>NZ_AP019739.1|WP_019131505.1|2586038_2587367_-|BACON-domain-containing-protein
MNLFHKIGLAVAASAALFAACSSDDDPFFARENDYLTFDCNEQTVEQSLQCDGAWSIDYDGNDDWIAVTPDSGVGNGELDFITVGVAYNRGGERTGTIYIDFAGHAYPIHITQGACDFAYGALSSAGTLVRGVESDFTLILAYANANGDESVALSCRMTGASEGLVAADCTFDKFQKGSGTITMPVTGVPAQTGEVFFELLVDGESKGTVKSTVVADPSSIVGGFPVWWDFSSESKPTLMADPHNYSWGAGSQYPCEDSAPSTDHKYLDWSDRGGYLTVVCSTASGWGYGEGHCYMKGLQKDDYWLMAFPVKNLKEGTRIAFEAAVGCSGSGARYYALEYSADGTNWFLAEGAETVTGVDGSTGPAHYTVMTDQALPNDKTPACGWASYTFPVEGCSVTDGLFYVRLRVSLDIRLNASATTYTISKTGSERLKGIVKVSLPE
>NZ_AP019739.1|WP_141419213.1|2584553_2585966_-|Ig-like-domain-containing-protein
MKTINRMVLLLATLFAAIGCSDDDKELVMYSLRFEPNSITLGIGKSYRLVPISDPFYDDVQYEWKSVDERVATVDQSGVVTGVSAGSTEVRAFYGDNRLARCLVSVVESTSSLPDPTAALSEGLSQQMIFSSNQLPYKGTIMQCFDFYDENGYIYYTQSVGDTKTGNRWMVALGRQKRNEAPSDDYMKLQWFGHGTLLVAERADDGDYVWVNSNGTLSGTDYTNNLTFSRIRYQKGAVLSHYAGDTFYMSEYVDAAGTTWMVRDVQPSIDFVNRRLLIGCRTTDMRHNVIYDLDAVLALGKETVEITRTWGGETAAEGVTEKKTETTSVEVRNLNRLTPLGSFRLPSYLNTGQTHQVYSYSHQGQAVWGDYVYWYEGQAIQQTGELYDGSVAYVAVFDYTGKLVCPRTRVAACSDFPSLSTLLDAKNCYCEGEGMQLKQGRKLYLGIATHTSAASGNRLASILQYECDVE
>NZ_AP019739.1|WP_019131515.1|2602980_2603916_-|DUF4974-domain-containing-protein
MERDLLYRYFDGDTTPDEERRIMEWAEASPENYRLYLEERRLWCALLLHAGRRTARRPALWRRLAAWRVSGAAACILLLVGLAGIFFAGRMVPDGRMQQVVVPAGQRVELRLADGTKVWLNSKSRLEYPSSFGRRSRRVTLCGEGYFEVAHDERKPFVVETGQYDVRVLGTTFNVYAYDNDRAAFETALMEGSVEVSSRSDASQRLVLQPNEAAVMAADGRLVRTRLTDMGRFRWTEGLICLNDVPFGELLERFSDYYDIRILLKNPKLYDVRCTGKFRQSDGIDYSLHVLQRFVNFRYTHDEERHTIEIR
>NZ_AP019739.1|WP_019131516.1|2604006_2604576_-|RNA-polymerase-sigma-70-factor
MDGSENRDCGLFTVLFEQYREPFTRFANSFVRDRAVSENLFVDALVDYWQRRGSLPEDTNVPAYLLTSVRNKALNHLRHQRIRERSSDELMRRARSELDFRISSLEDFTTQSLFSSEIHEIVRQTLAEMPAQTRRIFEMSRFENRRNAEIAAELNLSIKTVEFHIGKVLKVLRVRLKDYLLFFFVFILR
>NZ_AP019739.1|WP_141419218.1|2604882_2606052_+|hypothetical-protein
MKNMLLFLFAALAWSATALCQTPADSAARPRKRVFIAHRGVNMRSTVAGENSLEAIRLAKAAGFGAIETDVRLSADGALVVMHDSTLNRTCLHADGTPLSEPVAVAGKTLRELRSDYILKAADPARRTRIPTLEEYLAECARNGLYTFIEPKLYDPTGRHYRDIVAAADAALGRDRYVVTSNNRANDVIRRTGIDDVRLMGILYQTTFERIEALGDVIVAVSATRFDEADYSRQVARVKAAGLMCESHADKFVHFDRINRHDIDFVSTDFLAPDYHGQGRLLAEYARADGFVLPASADEGAIRLGEGQSIVPKRQLPAVPFGALYLELEAEGSARIELGGQTFTLDVPDKRTVTHQVLLHDAAPALRITALAGGITLTAIRAKVVAFEQ
>NZ_AP019739.1|WP_162502212.1|2606169_2607705_-|serine/threonine-protein-phosphatase
MRTRYFIGGILLLALFAGCLSDSGEGDAPGGGSGDLYGYVRDASGSAIEGVVVSDGYTCTVTGADGRYAMQRHPNAYYVYYSTPADCKVEVDPSTGLPLFYQKIRKSQPQYDFTLTRQAEETKFRMLAIGDPQVTTTAQVYRFETETVADINSYVAAQTDGLPTYAITLGDIVGNKWELYPDMVKAMARSKTSVPVFQTIGNHDHEFPQVTDLSAQRRYEASFGPVNYSFTRGDVHFVSMDDIIHKATGSDAYTSGFLDWQFEWLKQDLSYVPRTCAVVLCVHIPFRGGFNGAGETYFDEVLELLAQFDRAWIFSAHTHNNKTNYTHAVGSKKIREYILGTSCGAWWHGTVCTDGAPNGYGVFEYDGTSLTNMIYKPTRYDETFQIRLYNGEDVFTGGTAKSWKFDLQQPKNRLMANVWNADDTWTIEVYENGVKTGDMAKKSMIDPWSSAYFCGFCGLKESYASKNDHIFYYTVKSPGAALRVVARDGYGNVFEQTEITTPLEADYPDAY
>NZ_AP019739.1|WP_141419220.1|2607794_2609603_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MLKKIIYLIVSGGLLLSGCSLDYEPLNGPSSGSFPASEEEAMAGLYAAYKGLANMTVKETPFPMRINDCISDIGTYRTGAGNQIKAMSSTLTADNTMCEKVYKTVYKIAGRVHLVLDNLDRLRGVIPEDRFNQIKAELLCIRAYYYDLGCQFYGDIPFIDHQLDLDDYSDYPRIPREQVTARLLQDLDDDLLDYLPVQWNPGTYGTTRIGRVAAYALKARIALNWGLWEEAARCSKIATTLAEGVYDLEPLDCTYYATHADGEPSAANLFGFAGQTSREWLWAIQYNRLINYTSATYYEAPRIHGGCSWLGPSQAMVDTFQCTDGKPITESPLYDWQNPWANRDPRLDLFCLRPDTRLWGVQYDTDVRVEKVKDYNQSTAGKEVLISNADAVGNKSEYAANGSKGPGGYLWRKYSDKGMMGLVNGTKTEDDINAGIIRFAELLLIEAEANIEWDGGDLAIAEANINRVRARVNMPPVTDRSREGLRKALRYERKAELCNEGFRWFDIRRWKIASKAVNGPMYAPGYSTVQNPGNYISNVRPSFDDDWVVTYDLSDTWDGKTGNLRVFQTMVFNPEKDYLWPIPYTELVTNPAIGVENQNPGY
>NZ_AP019739.1|WP_141419221.1|2609615_2612612_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MYAQKSQLSGTVSDAENIPLVGASIIVEGTHVGTTTDADGAFRLPAAPGQRLTVSYLGYKSKTVTVGNRTSLDIILESDNSLINEVVVVGYDTQKKVNLTGSVASVSAEDLANRPIVSSSTALQGIAPGVTVTTQSGAPGGDGGMIRVRGIGTFGGSSAAPLVLIDGVEGSLDAVDATQIDQISVLKDAASSAIYGSRAANGVILVTTKRGKKGQTSVTYRGYVGWQSPTDTPETVSAEEYMILSRETSFNDGKESIYTDDYIARYRENNRIDPDNYPLTDWQDQILTGSGFTHNHNLSLTASTERVRVMTSFGYLDQKGIIKRTDYQRYNVRNNMNIDFSDKLSMRFDVSFVNGDRRRIPQQNTLFNYMNTRDPLILSRWSTGYWAGLSGGSTNVLPTLEGEGGNVKNNTIRLNGAVTLTFKPVKWLTLEGMVAPRYVTTNNHTFVKKMKFYSDAFGTVSNSSNVAFNYLDESANRSFYGNYQFTAALQHTFAQNHNFKLLLGASRETYDNKTLSAHREDFAYPDYEVIGAGADNETKDNGGGHAQWALQSFFGRLNYNFKERYLFEANVRFDGSSRFAKGNRWGIFPSFSGAWRLTEEPFMQDVRRTLSEFKIRASYGQLGNQNIGSNYPTIQQLDVSSISVNDVITPIVTQTTLANPDITWESTEMYDVGIDATLFDKLSVTADWYYKKTHDILLTLDIPSIIGLGAPYQNAGTVRNVGWEVAVGYHNKWRDFSFGVEANLSDVVNKIIDMKGTTGGSGAIRNQEGSAINSIYGLKCVGMARTQEEADWVNENCPQYGVTTKPGDLIYADMDDSGTIDDKDMTIIGSTVPRYTYGVNLSFGWKGLNLSAFFQGVGKVDGYLSSYYVQPCQQGGTFRKEHLDRWNETNPNGKYPRLTMTDANNWKQSSFWMRSAAYCRLKNIQLSYTLPRTWLKKLRMKSAMVFVNAQNLFTITDFYQGFDPEVAYSGSGDGVELGAVAYNYPQVKVVTMGVELKF
>NZ_AP019739.1|WP_141419222.1|2612707_2614531_-|hypothetical-protein
MIRNLLPWTAGCLLAAFAVSSCESDDVDYGPISAAIEIGVEEVTPSSAKIRLTTEQENVASYKIVKPTPISEFEYAAHDAIDRLAFIEERGEAAGAPFEQTLAGLMPKVEYSFAVVGLDASGQRITAPTFARFTTAYASSLVEARFETNPDETFTFTGKITPNAYTVSYRYIFDSDHNEATEAELRALLEAGGSGVKTDKGVKELELVKSDKAGVTLAVLSYDDANRPGEFTSTFVSTEDMASVIVDGKETQLARPTEGVDIFEGKVAVPAKSGFTVEINKVAYGFAPYSGNGGVGKVENMMSAAPYYSSSTIADSRGYDCKMAVGRMAATADGGNDFWTNLSEDAHILVRVDLTYADGTPRYWLELVEADDPNLLLEQNFDLFVWGGDYTLASGGKGTAPVADSESAADLDGTEEGTKGGATYTTPKPDIWSTADGAADGDVIAGDLYLKNRNMTGWEVRRIAEHPGTVRLNKSASGSHKYSGYLKTPKLAALTAPTNITLEFDICRFAGDGDIYITVEGAGTYTAAAVNIDGAAAATTVAASGTDFVVTNDLCSKQANTVINKPWSHVELSIAGATAETQIKFDGSRGKDSASDRCLLDNIKITK
>NZ_AP019739.1|WP_141419223.1|2614757_2616425_-|hypothetical-protein
MKPIRKMRLFAAALAVACLLAATVRTVAAGRGKAVLTGVVYGDGAPLAGVCVSDGVQFATTDAAGRYRIESDKSAGFVFAVTPSNWVAAEADGVQPLFWAALDEADARDEQHDFHFASVDQSRYTVMFFTDLHLTNSSEKRDLDHYRSIALASISDEAAQASARGPVYSLNLGDLSHDLYWYQYDFDVSSAKRFLEQNGFPTLLYSIPGNHDNDGATPAGVGVDRRAEHLYRRTFGPTYYAMNIGDVHWIMMDNIIYKNTPGKGKKNVGVVGARDYDKGFTPEQLAWLRRDLATVDASKTVCLCTHCPVFFDRDRRTLLTDRSQVDSLDALFSRFERVHIFSGHAHRTLYTQDADYPRFDQYVLPATSGDMWVANNDFQALCPDGSDAGFVVASVDGGKLRCDYRTHLYGRKVLRAYDMNAVGEYYRNDSLVRVQRRLYPDRADYGREEYANCVYVNYWGYLPGHRVELFEEGRPLEVVQVEDEDPLYNISHYLPELARKPVFKKGDARVVSHHMFAARARTATAPVEIRITDADGVLLHRETLERPKKFDKEAR
>NZ_AP019739.1|WP_141419224.1|2616421_2617753_-|histidine-type-phosphatase
MNLISIFRRLFLPLVVLLLAATAGAQSAYDEIKADIDKAGGVYFMYPFDTPSATPAPKGYEPFYISHYGRHGARYILSNDQYDNVAEVLRRARADGKLTARGIDACDRFLAIYPHLKGRAGDLTPKGQMQHRRLAGRMYAAYPEIFRRHPRIEAYSTVVPRCIMSMAAFCEGLKEADPSLEIFTETSSVNMYYLNPHSTGNPAGTAEDFRYKSADAPWRPEWRRFCEERIDVETILVRLFTDTAYARSICDPLKFEQDLFSVAAHMQCTDLDESFYDLFTFDELCRFWECDNYTYYVEKGPDPRNRGRGTALAETLLDDIVSRAGEDMAAGEPSVRLRFGHDGCIMALLTLMRIDGWTTPVTDPAKIKDVWQVHRIPMASNMQFVFYRNKKNPDDVLVRVLLNEKELRLPLPGDRAPYYRWEDFRDFYAGIVREARLKLEATK
>NZ_AP019739.1|WP_141419225.1|2617764_2618658_-|carbohydrate-kinase
MGKPKIVGIGELLWDVLPAGRRLGGAPVNFAFYAQEQGAEACIVSAVGQDASGDELLGGIAALGLGVRAVQRNAHPTSTVEVTLDAAGVPAYRIREQVAWDYIERTAEADAAVAGAAVVCWGSLAQRNAVSRRTILALVDAAPVGCLRLFDINLRLNYYDERIVRDSLERADILKLNEDELPVVARFFGLEGAAERVVAQLFERFSLRYVVFTEGGRGSRVTAADGRTSYLATPRVEVADTVGAGDAFTATFAASLMQGLPMEECHRRAVAVAAFVCTRHGAIAPLSEFMKTEITNR

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Crispr_ID: NZ_AP019739_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_19

2763225-2763379

Orphan

Consensus_repeat	Method
TTTTCGGAGCGGAAAGTGGTGCAAAGGTAAAACCTTTTTTCGAATCCACCAAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_19

>merge|NZ_AP019739|19|2763225-2763379|CRISPRCasFinder
TTTTCGGAGCGGAAAGTGGTGCAAAGGTAAAACCTTTTTTCGAATCCACCAAATTTTTGAAGAACTTTTTTTTCGAAGCTTTTTCAAAACCTCTCCGCCTGTTTTCGGAGCGGAAAGTGGCGCAAAGGTAAAACCTTTTTTCGAATCCACCAAAT

>NZ_AP019739|19|18|2763225-2763379|CRISPRCasFinder
TTTTCGGAGCGGAAAGTGGTGCAAAGGTAAAACCTTTTTTCGAATCCACCAAAT	TTTTGAAGAACTTTTTTTTCGAAGCTTTTTCAAAACCTCTCCGCCTG
TTTTCGGAGCGGAAAGTGGCGCAAAGGTAAAACCTTTTTTCGAATCCACCAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141419276.1\|2748348_2750406_+\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|372640
NZ_AP019739.1\|WP_019130949.1\|2766811_2768197_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419279.1\|2752589_2753711_+\|cell-filamentation-protein-Fic	unknown	unknown	gnl\|CDD\|225095
NZ_AP019739.1\|WP_141419288.1\|2773726_2777293_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_141419281.1\|2755922_2756429_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_008024684.1\|2777846_2778863_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271183
NZ_AP019739.1\|WP_019130946.1\|2771905_2772505_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_AP019739.1\|WP_141419278.1\|2751820_2752576_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_162502215.1\|2763640_2765677_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173811
NZ_AP019739.1\|WP_008024683.1\|2778868_2779873_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271178
NZ_AP019739.1\|WP_141419282.1\|2756545_2757766_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340895
NZ_AP019739.1\|WP_141419287.1\|2772574_2773606_+\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP019739.1\|WP_141419280.1\|2754364_2755498_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271185
NZ_AP019739.1\|WP_141419277.1\|2750420_2751806_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341205
NZ_AP019739.1\|WP_141412323.1\|2744099_2744846_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
NZ_AP019739.1\|WP_141419286.1\|2770390_2771269_+\|DUF4249-family-protein	unknown	unknown	gnl\|CDD\|379442
NZ_AP019739.1\|WP_019131622.1\|2744852_2747228_+\|BamA/TamA-family-outer-membrane-protein	unknown	unknown	gnl\|CDD\|227116
NZ_AP019739.1\|WP_141419284.1\|2766102_2766708_+\|peptidase	unknown	unknown	gnl\|CDD\|237816
NZ_AP019739.1\|WP_141419275.1\|2748137_2748338_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_AP019739.1\|WP_162502216.1\|2768262_2770383_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|366183

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141419276.1\|2748348_2750406_+\|N-6-DNA-methylase	gnl\|CDD\|372640	pfam13588, HSDR_N_2, Type I restriction enzyme R protein N-terminus (HSDR_N). This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.	4.64424e-33
NZ_AP019739.1\|WP_141419279.1\|2752589_2753711_+\|cell-filamentation-protein-Fic	gnl\|CDD\|225095	COG2184, Fic, Protein involved in cell division [Cell division and chromosome partitioning].	5.78402e-18
NZ_AP019739.1\|WP_141419288.1\|2773726_2777293_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_008024684.1\|2777846_2778863_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271183	cd01182, INT_RitC_C_like, C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	1.46926e-81
NZ_AP019739.1\|WP_019130946.1\|2771905_2772505_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	1.97754e-44
NZ_AP019739.1\|WP_162502215.1\|2763640_2765677_-\|S8-family-serine-peptidase	gnl\|CDD\|173811	cd07485, Peptidases_S8_Fervidolysin_like, Peptidase S8 family domain in Fervidolysin. Fervidolysin found in Fervidobacterium pennivorans is an extracellular subtilisin-like keratinase. It is contains a signal peptide, a propeptide, and a catalytic region. The tertiary structure of fervidolysin is similar to that of subtilisin. It contains a Asp/His/Ser catalytic triad and is a member of the peptidase S8 (subtilisin and kexin) family. The catalytic triad is similar to that found in trypsin-like proteases, but it does not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	4.78547e-69
NZ_AP019739.1\|WP_008024683.1\|2778868_2779873_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271178	cd00797, INT_RitB_C_like, C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	2.05496e-51
NZ_AP019739.1\|WP_141419275.1\|2748137_2748338_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	7.91789e-09
NZ_AP019739.1\|WP_141419287.1\|2772574_2773606_+\|DUF4974-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	1.6986e-28
NZ_AP019739.1\|WP_141419280.1\|2754364_2755498_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.13009e-55
NZ_AP019739.1\|WP_141419277.1\|2750420_2751806_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341205	cd17524, RMtype1_S_EcoUTORF5051P-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli UTI89 S subunit (S.EcoUTORF5051P) TRD2-CR2 and Archaeoglobus fulgidus VC-16 S subunit (S.AfuORF1715P) TRD2-CR2. Escherichia coli UTI89 S subunit (S.EcoUTORF5051P) recognizes 5'... CCANNNNNNNCTTC ... 3' and the recognition sequence of Archaeoglobus fulgidus VC-16 S subunit (S.AfuORF1715P) is undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases, such as Pseudomonas putida Jo 4-731 Type IIG restriction enzyme/N6-adenine DNA methyltransferase (RM.PpiI), and type I DNA methyltransferases such as Bacillus cereus BDRD-ST24 M subunit of Type I N6-adenine DNA methyltransferase (M.Bce24ORF51270P). RM.PpiI recognizes 5' ... GAACNNNNNCTC ... 3'.	1.0802e-68
NZ_AP019739.1\|WP_141412323.1\|2744099_2744846_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	1.28724e-67
NZ_AP019739.1\|WP_141419286.1\|2770390_2771269_+\|DUF4249-family-protein	gnl\|CDD\|379442	pfam14054, DUF4249, Domain of unknown function (DUF4249). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 279 and 365 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.	2.6763e-22
NZ_AP019739.1\|WP_019131622.1\|2744852_2747228_+\|BamA/TamA-family-outer-membrane-protein	gnl\|CDD\|227116	COG4775, COG4775, Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane].	6.531e-30
NZ_AP019739.1\|WP_141419282.1\|2756545_2757766_-\|MFS-transporter	gnl\|CDD\|340895	cd17337, MFS_CsbX, CsbX family of the Major Facilitator Superfamily of transporters. The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.09061e-173
NZ_AP019739.1\|WP_141419284.1\|2766102_2766708_+\|peptidase	gnl\|CDD\|237816	PRK14788, PRK14788, lipoprotein signal peptidase; Provisional.	5.34999e-59
NZ_AP019739.1\|WP_162502216.1\|2768262_2770383_+\|TonB-dependent-receptor	gnl\|CDD\|366183	pfam00593, TonB_dep_Rec, TonB dependent receptor. This model now only covers the conserved part of the barrel structure.	1.0631e-15

>NZ_AP019739.1|WP_141419282.1|2756545_2757766_-|MFS-transporter
MTTFYDKTGLPKSLAWGFIGVLIFMMGDGIEQTWLSRYIASQGLDHEVLFTVYGISVALSAWFSGVIAETIGVRRTMLLGYLVYLVGMAGFAGIGMMGLNYPVMLVTYAIKGLGYPLFAYTFIVWIAYRVDKSRLSSAQGWFWFVFTGGLNVLGAYYGAYAMERIGVVPTLWSSLVFASVGAVLALWVNKCDDRNLFVGAERPSSGTSKFRELLSGLAIMKREPKVLVGGIVRVINTTSQFAFVVFMPLYLKDYGIGDTQWASIWGSIFLFNILFNLIFGIVGDHIGWGRTIVWFGGVGCAVSVLLFFYAPVICNNFWFILACGALWCIMLAGYVPLSALVPSLVDKDKGAAVSVLNLGAGLAAFVGPLIVALFRNAIGYVGIVWFMAGLYILSAVMTYCIAPRNR
>NZ_AP019739.1|WP_141419281.1|2755922_2756429_+|hypothetical-protein
MKLFHYLPVGVCAAAAALLLASCGVSKRSLKQSNRALTAALQASAQKEQAEALKLYSDTSIPQGEARKSVSRDNPGQTALEQTIIRWAIDSDPQGARVFYRVLSSIPAVVKNTNETYLMTTPYEETRAFNILGLTYENSRDVQIEIKVVKTGYEAQVKRFNVRQAIDQ
>NZ_AP019739.1|WP_141419280.1|2754364_2755498_-|tyrosine-type-recombinase/integrase
MPRVKKPAKVKEPIRLRMKELANGNKSLYLDIYRDGKRTYEYLKMYLIPETDNNARVRNQTTMAAANAIKSKRIIQLTNGEAGIETREKVFLLDWMETYKENQAKRGKKDGNQIQVTIRILKDYAGERVTMDQIDKAFCQEYIDYLLTEYRPKGKRVSNFTLHTYYRILNGALNAAVRAEIIKVNPFTKINNSDKIRLPESKRSYMTIEEVRALIATPMKNEAVKQAYLFSCFCGLRISDIISLKWKDVFVDRGQYRLAVSMQKTKESIYLPLSPEALKWMPERGEKTSEDHVFDLPSPTMINTLLKPWAKAAGIDKRFSFHTSRHTFATMMLTLGADLYTTSKLLGHADVKMTQVYAKIINQKKDDAVNLVNGLFD
>NZ_AP019739.1|WP_141419279.1|2752589_2753711_+|cell-filamentation-protein-Fic
MTNFDEYIRQGEPQKREKGYAWQTAIGLQAIDGLKPSDYLIETARKDIEGEITIDEAEQLIRSYYQSKIAHTPEDAEIHEADMASTNIRRLLTEKTFAFTLVGLTSIHRRIFDGIFKFAGQIRDYNITKKEWVLRGDTVLYVSAPDLRKAIEYDLEQERQFDYSKVDRNGLVSHIAKFVSGLWQIHPFGEGNTRTTAVFTILYLRSMGFDVTNDLFANHSWYFRNALVRANYQNVQKGIMRNSEYLERFFCNLLLGENNELRNRYMVVNAPEELTAKQVQQIDRTSTEQPAVQVTEQVRALLLALSNEQLSLKVLMEKVGLKHRPTFLENYISPASEDGFLKVLYPDKPNHPRQKYLLTAKGLALYNEIKKMQ
>NZ_AP019739.1|WP_141419278.1|2751820_2752576_+|hypothetical-protein
MKIIDLVAILGALAWLPQIISWIYHWLQKPMISVYHEEEAEVGFIKFGNAFNIRLSFLARRKHALIDNIELCITDKDGANHTFKWIWYSETLYELQAPTGNATMAKQQNAIAINAYKDVLIEKFIGFQSSSFLDRRKQLAYKLNSFIENQRTVGQIDADAIRRSNEYNELLRLYKNSMIWKTGDYSAICKIHIADTDTYMQHSFKFRLSDIEVETLKKNIEFARKIIDVEFINPQQQIEGTWLWTKPSIDI
>NZ_AP019739.1|WP_141419277.1|2750420_2751806_+|restriction-endonuclease-subunit-S
MEGLEIKEKKLYEVLSNKDFRIDSSFYTKEPKKNPDLIYAKIGEHLISSQYGISIEMNTDSVGYPIYRMNEIHDMLCDLDVDKCADITQAEYDRFALKDRDVLFNRTNSFEWVGRTGIYYQNDDIQRTFASYLVRLNPKDSILPEYLCAYLNCKYGEWDVKRRARQSINQTNVNPEEVKEIEIPILDIDLQQKIQCCFTQANSLRILSQKTYSEAELISHNELGINSIAVTDVNVSQKRFSDFINSGRLDAEYYQPKYDEIIGTISQYPYGHDKIGNLYILRDKNFLPNDNARYKYIELSDIGVNGEISGCTYDYGSNLPSRARRIVHTGDIIISSIEGSLQSCAIITEEYDGALCSTGFYVLSPRIINSETSLVLFKSSAIQALLKRACTGTILTAMNKDEFMAINLPVINKDIQNKIADIIRQSTILRSESKRLLNLAKTAVEIAIEQGENTAMKLLTI
>NZ_AP019739.1|WP_141419276.1|2748348_2750406_+|N-6-DNA-methylase
MKLYEILKGSEYSLDMFSQEVIAELENRIIERIDKKGKTYPVVSCLVRNKEIKLTPEEIVRQLYAAKLINDYGYPKSRLAFEYPIYFGRETKRADIVIRDNDDANVAYIIVELKKPKAKDGREQLKSYTHATGASMAVWTNGTTIAYYQRQNPNYFKDIPNIPNVHQTLEDILQTPFTMDDLVKNDKLTKTGKSLKDLILEMEDEVLANAGVDVFEEVFKLIFAKLYDEQIGATEKDYNLVFRNSGQSDIQLKNKIEDLFRKACSKWTGVFAKDAKIALTSPHLSICVSSLEGVKLFNSNLDVVDEAFEYLMSKSSKGEKGQYFTPRYVIDMCVKMLNPQVDETMIDTAAGSSGFPVHTIFHVWKQMQIAANKPVNHLFTATPKSHAEIEYVQDNVFAIDFDEKAVRVARTLNLIAGDGHTNVLHLNTLDWARWNTVTKEETWVDTYNDGFKKLKQLRVGNDFGQFNFAILMANPPFAGEIKEGQILSRYDLGMKNGKAQKSVSRDILFIERNLNFLKPGGRMAIVLPQGRFNNSSDKAIREYIAERCRILAVVGLHGNTFKPHTGTKTSVLFVQKWDDILCPKVDDYNIFFATQQKEGKNNSGDKLYWKSDKSGTTTDPKLALCDKYGHPIVYHDLLATVNYNWNKEKKCNEIEQITPDGIAEAFVEFAKKEQLSFFADAPLIK
>NZ_AP019739.1|WP_141419275.1|2748137_2748338_+|helix-turn-helix-domain-containing-protein
MDKPKNRIKEVLEEKGIKQIWLAEKLGKSFCIVNSYVCNRRQPSLDVLFEIANILHVDPKDLIISK
>NZ_AP019739.1|WP_019131622.1|2744852_2747228_+|BamA/TamA-family-outer-membrane-protein
MRRLYPIAVAALCILCTACSVVRKLPEGSYLVQKVTIEDDRNVPKKERITASELDRYVWQSPNKRFLGTNFYVWVYNQSNPDKDNWWNRFKRKIGEKPVVYDPALTLKSAENLKAYMESHGFFSSRVRYHVDTTSRRKRAIITYRTEQGPPSRYGKINYEFNDKFIEKIILQDTASTLIRPGGIFNSATLDAERERITRYLRDRGYYNFSVNNISYRYPYDTVGSRVGDLTMVVKQYLTGYNDRGEPVMENNKVYRISEINMLPGYDPTVSFTDREVRYDTVAYRGLNVVYDGKHNVRPRVLRQAIPLYPNYLYNAEQINRTYNNIMSLGYFKSTRITFDELPAPDSTNLVSYIGNADDSLATQYTQEGYLRCNILGTPQLKQSYKIDLEGTTTSSFYGLKASVGYQNRNLFRGMESFDIAFSIGHEFMKSRDSGKRNAKEFGVTAGLAFPRFLLPFFSSRYRPSLVTPRTRLELSFNYQDRPYYRRTLTSMTWTYSWSNEKYSSFAVRPVDLNLVDMSYINQDFFEKLQNLYLRNSYTSQLVAGISGSYTYNNQLKNPGRNATLVRFNWETAGNLIGGLEHLFSSPAKGKDYYEIFGIQYSQYFRVDLSASRKIMLGEKAAIAGRLYAGCGLAYGNSTSIPFDRLFYCGGSNGMRGWIPRMLGPGSVPVDPDKVTYPVQLGDMKLEANLEFRFPIWGIFHGATFFDVGNIWFMGNSAEEYPPEAVFHIRDFYKQLGFNTGLGIRLDIKFAVLRLDWGIQLHNPNNPAGKRWIHDFKWSNTALNFGVGYPF
>NZ_AP019739.1|WP_141412323.1|2744099_2744846_+|NADPH-dependent-oxidoreductase
MIKEIANHRSIRKYKSSPIDEEVLSDILHSAARASTCGNMQLYSLVVTLDARVRAELAPCHFNQAMVTEAPCVVTVCADVHRFSKWCEQRDAEPAYDNFEWFLNAATDALLAAENLALAAEAHGLGVCFLGTTLYTARDICRILHLPKGVIPLTTVVIGHPAEQPPLTDRLPLDAVVHYDRYKDYTDAEIDELWAEKEASPETSALLAENGLPNLAQIFTRNRYRREDNIAISRAYFELLREQGFFNQ
>NZ_AP019739.1|WP_162502215.1|2763640_2765677_-|S8-family-serine-peptidase
MMKKILLLAGIVSLAACTNDPEETFSQGGGSSAGVKVIYDAEGAVEGQLIVKFRPSAADSLAAALASASATRAGFATADELLAAVGVDGIRPLFGSDPRFEERHRAFGLHQWYVVTFDESLPLREMVGELSHDGRIEVLEYARCPRLKNRFPARPLRSAAAAATRASMPMNDPLLPAQWHYDNTGYQVLVTQAGADVNLFDAWKKNQGSSDIVVAVIDQAVQYTHPDLQANIWVNPNPTKGDQHGYNFVNNTAELDWSYADRKEYQGQIYYSNADHGTHVAGTIAAVNDNDRGVCGIAGGRNGAGGVKIMSCQIFGDPDKRSYPTEDAFRYAADNGALICQCSYGYSYSTGSRDEMEAMRQWFMNSSEKAAIDYFIANAGKNDPDSPIEGGVVIFAAGNDGDLFGDVSEYPASYEAVVSVAAMGSDFLPAYYTCYNDEVDITAPGGDLYNSSLGTDNGGVLSTILSDPSVTYYDDERRQGLTDSNVYGYMQGTSMACPHVSGVAALGLSYLSQLGYRMTADAYKKLLLESVHPIDPYLTGTKRYDGPTLLLDEYKGKMGAGYLDANLLLENIKVAFGEKTPPRVTARIANRLLKTDTPTSSVALADYFTDDVVSQYDAVANDESVVRVNVSDGVLRMLPKKVGQARVTVSARGFEGTVVSQSFYVTVRSQSNSADGWL
>NZ_AP019739.1|WP_141419284.1|2766102_2766708_+|peptidase
MNFKKITILLLVLLVADQALKIWIKTHMTLDEAIMIVPTWFQLRFIENNGAAFGMRLATGGAFDWGKLALSLFRLAMIGLLGYYLRYLGKRKTPAGVLVGLTLILAGAIGNMIDSAFYGLIFSASTPTEVAHFGGSYAPLMMGRVVDMFYFPLFQWNGVPGWLSFLVDSRNYFFGAIFNLADAYISVAVVYLLIFQYKFFK
>NZ_AP019739.1|WP_019130949.1|2766811_2768197_+|hypothetical-protein
MKKILLCLALFCLATGPISCGDSNTDDGTEQGGGGNGGDGGGTGPEPEPGNPEITPEQHKAKLETIGKEVAAQFNPEDSKAAIESLTALEELLAFDDEDVAPSPAPKTYAVATAKSLAAVAAGPDVHALTSLIVRATTTEKYTLDEWAGDYVIEDGEPVKKGELANQYRLTWADAAGTQSEALFTYSAGGVEYTRVDGYAIVIPQDWNLSLKVAGHEELSVVGKSNVSADGLTLAPEVTVTLNGGYVAAAKVNADPKQVTANASFTKNGTQIVDAYAKMVCDGLTDPDNWIVEEEYDWNGDGVIDDTDTYIDPEDHIVDHVKTGEGYVTVMGLKLTLSGDIAKIIQQVNAIADTSTATGSQQEADAYNTNAKAKLAYTADNSTMADVKMQSYSYKDYIYVWNPDTQTGDNQVVTRYDIEPVLEFADGSKIAIEEYVETGFDSLTKTFEDLADAYMDLIDGK
>NZ_AP019739.1|WP_162502216.1|2768262_2770383_+|TonB-dependent-receptor
MTNTLTRLLLTAALCGLFLLSEAQERNAVSAPDPAAPRMPADSISRDYRLDGVVIGTQRPPSPLGSIAEGRFRLLMRNSSALPRFAGSIDPMRILQLMPGVQTAAEGNSGLYVRGNDAGQNLILLNQAPLYAHAHLLGFFSVFNPGQVASFELSKTGGGRIETAMQPATVVVQSREETGVRWGVEGDLGIIASQATVTAPLTDRAALFLSGRRSYTGWLIGALSPKGEDDLNYRLQDYDATLAWQIDDHNKLIVNSHYGDDRTHITYNEGLLGGRLQWYASVSSATLRSELSPTTHMENALYYSRLDTRLTASTTGISAQAPSSIGDLGYKHSTRWHIGRLQLAAGLQYAYRRIRPQHIASDYGGIADAGRGPRYDTHELAPFLAATIPLTHSLTCDAALRYGFYLLQGDGRIASYRHASPQPSLSLDWQVARGSRLRASYNYITQYIHKVPSSNISFSTDFWMAPTRRTPPQHTHHAALGYFAEAAGGRLNFSAEAYYQRMYRVLEYNAPLTGMVNNRYELEQYLHSGDGEAYGMEFMVSYAGRKFNGWISYTLGKSVRQFAALNDGLPFPASLDRRHDLSLAASYMPGERWELSTVFVYASGGAYTPTRDLYIAGGSFVRGHGSYNGARLPDYHRLDLSVTYWLRRKPWRSGINLSLFNLYAHRNPLYISWPVLVDEEKHEYQIHPRRHYLYTVIPSVSWIFKF
>NZ_AP019739.1|WP_141419286.1|2770390_2771269_+|DUF4249-family-protein
MKRSVILLFTLLGSCLGKVSTDTEYHRQLVVEGRIEAGGPAEVMLSENLPFLDVITEQTLEAAVVRYAKVTVTSDDGQSEILTGYYDRNYPTRFVYRSARLHGRTGGTYTLTVDYRGRTCTAVTTVPEPIPLRELRAEPVCDSLFTLQALFDDPPAKNAYFAECRTTDPGAYSPALMGVVDDSVLDNGGSVTLTVNRPLQYLKIKDYKQYFRPGETVDVRFSHISSPTFDFWSRLENEMLNAMNPVFPAYENLPSNIEGDARGIWSGYGSSYYRITMPQENDSKETTVFPPA
>NZ_AP019739.1|WP_019130946.1|2771905_2772505_+|RNA-polymerase-sigma-70-factor
MKAEESILIERLKKGERTAFNELYGIFWAPLVNYAELIVGDENADDVVQEVFVRIWVGRDKLRNDGSLRGYLLRAVYRTALNVLRSKNYASSYRSQTKLQIEQQLCTYYDPDENEIIRNLYARQIADELDAVVETLSPKCREVFRMSHFEGLSNREISERLNISVSTVENHINNALRQLRGKLGHLKMFLLLTIYILGQ
>NZ_AP019739.1|WP_141419287.1|2772574_2773606_+|DUF4974-domain-containing-protein
MKNEDSQHPFNERIIWKYFDGTATSEEEQELSQWLATSEKHRREVAELRAVRQRFAKWRSTLYGPARFIRSLNRLNSRIDALENAPCTVQRPHRLSNLFGHIRIHSLLRTAAVVAVVALTGMFAWRTALMLAPITYFNADTTIMHVAMPDGSDIWLTPGSTLCYDETFHTDERRVHLDGEAYFDVEHDAKHPFDVVTPNLRVRVLGTVFSVRSLRGDHMAETTLAEGAVSLQRADGSNLIRLHPGQRAIYDTQDEQLEIKEVPVGDHLALSYGIITLDGVPLRQIADRIEELYGVKLRLVDDDAPDANYNFSFQKDTPIEDVIELLQFISGTRFEILRYPDSD
>NZ_AP019739.1|WP_141419288.1|2773726_2777293_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKKIGLFLTGWCRMLLCVGLAALPSASLGARGELLADQRLNLNLSFDSASLREVVSAFTEQTGVVFSYETSLGKRTLSDVHVVIQDAPLEEMLNTLFYDTGISWKIKDHVVALTAIPSSKKNVSTGSAPSPSANRKPVVTGRVVNEEGEPLVGVNVLVKGTTQGTSTDIDGSYSIAVADDDVLQFTYLGYGSAEWRVGTQTRIDVVLKEDKQMLDEVVVVGYGTVKRRDLVGAVDQVDSKVFSERSNPSISRSLQGAIPNLNISMRDGKPSRAATINIRGTGSIGSGGGALVLIDGVEGDLETVNPQDIASVSVLKDASSAAIYGARGAFGVILVTTKSAEEGETKVTYNGSFSLHARTVKPQLVTDGYEWTTGYINAWNGYYNGQNPLPSYINNIAPYSDSWYKELARRSTDPSLERVRINDKNQYEYFANTDWMDAFYKDFNYSHEHNISVSGGNQNADYYVSGRFYDQDGIYRVGDERYKQYNVRAKGNIRIRPWLRLNNNMDFTVVDYHQPMLYYSLQLPQRMIEHGGQPINPITNPDGTWTYAAVLNGYAGFAEGSSYQQDDKFTMKDKLGIEIDVVKDVLKISGDLSYLFARNKRERVTNMYTGYRGPDTPITVNESQGSTLENLRQDTNYLSSNIYGEYTPKLGDDHTLKLLAGWNLETKKYRGTTIKREGLTVPSKPSFGLMDGLTSDPVVSGYDWSYVGAFFRANYGYQGKYLAEFSCRYDGSSKFPENSKWGFFPSASIGWRLSEEKFMEWSRNWLDNFKIRLSAGSMGNGNIDPYKYIDYMTIKTSTVVIGDALGSYTTAPGAIPLSLTWETATTYDVGFDMDLFRNRLSIGFDWYRRYTTDMYTVGVSLPSVYGTDAPKGNNASLKTNGWELSVGWRDSFELGGKAFSYNVKAMVWDARTWVTEYINPTGALGDYYEGKELGEIWGYRVEGLFRDQEDIDSHAEQSFLQTLDKVTRPGQVKFADLNQDGKIDRGAYTTADPGDLTVIGNETPRYCYGINLGFNWNGIGISTFWQGVGKKDWYPRYDSGFFWGQYNRPFGYMLKQHTGDKVYREELDNWDTAYWPRYTTYQTHQSSVNRPLTINNDRYMQDVSYIRLKNITVDYTFPDRICKKLHIKGLKVWVSGENLWTYSPMFEHCDNYDPEVINAGDSDFRTSEGDGYSYPMLRTVTLGVNLSF
>NZ_AP019739.1|WP_008024684.1|2777846_2778863_-|tyrosine-type-recombinase/integrase
MKPTNFSKYLTDFLLRYLPHERGASTNTIHSYRDTFTLYLVYMESKGVKAEKLTMESITKENILSFLDWLETKRSCCTSTRNLRLAAIQSFFKYLQYQSSDHLYEYQEIMAINNKKSVKPIMNYLTVEEMKILLQQPDTTKPKGRRDLALLSLMYDTACRVSEVISLTPQCVRLDEPYTVIITGKGNKNRVVPMLEEQLDILKIYMKENGLLRSECLQHPLFTNCWGEKLTRAGVANILDRYIKKAKLLHPTLMKGKISCHSLRHSKAMHLLQAGVNLVYIRDILGHVNVQTTEIYARADSKVKREAIEKAYIKVVQEVDTKPMWQGNEKLMDFLKSF
>NZ_AP019739.1|WP_008024683.1|2778868_2779873_-|tyrosine-type-recombinase/integrase
MYHLYVKTFIPRKEAIFMNRNFKGIYASLIREFVSLKRSMGFKYIGGEFVLTLFDRFTIERNETAIGITKELSDAWCKERDNESNSYHYRRCYILGAFSSFLNKKGIRSYIPRTPSLRNTFIPHIFSSKEIERIFTTCDNMQSGNNDMRSSFFIMPSLLRMLYGTGIRIGEALSLLNEDINLEEEYFILRDTKNGKDRIVPFSTSLAEVLKDYVVHRNRLPVKISDTTPFFITLKGRACDRDSIYRRFCKILIQANIPKDRIRLHDLRHTFAVHSLAKMAEEGMDLYCSLPILSTYLGHQSLRATNNYVRLTSEMYPELIRKIDIIGFDIFPKM

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Crispr_ID: NZ_AP019739_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_20

2765728-2765824

Orphan

Consensus_repeat	Method
CAAATTTATTTGAACATTGCCGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_20

>merge|NZ_AP019739|20|2765728-2765824|CRISPRCasFinder
CAAATTTATTTGAACATTGCCGAGCGGGAGTATCTTCGGCACAGCCAAAGATACGATTAAGCCGAGCGCAATGCAAATTTATTCGAACATTGCCGAG

>NZ_AP019739|20|19|2765728-2765824|CRISPRCasFinder
CAAATTTATTTGAACATTGCCGAG	CGGGAGTATCTTCGGCACAGCCAAAGATACGATTAAGCCGAGCGCAATG
CAAATTTATTCGAACATTGCCGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141419276.1\|2748348_2750406_+\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|372640
NZ_AP019739.1\|WP_019130949.1\|2766811_2768197_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419279.1\|2752589_2753711_+\|cell-filamentation-protein-Fic	unknown	unknown	gnl\|CDD\|225095
NZ_AP019739.1\|WP_141419288.1\|2773726_2777293_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_AP019739.1\|WP_141419281.1\|2755922_2756429_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_008024684.1\|2777846_2778863_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271183
NZ_AP019739.1\|WP_019130946.1\|2771905_2772505_+\|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl\|CDD\|274376
NZ_AP019739.1\|WP_141419278.1\|2751820_2752576_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_162502215.1\|2763640_2765677_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173811
NZ_AP019739.1\|WP_008024683.1\|2778868_2779873_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271178
NZ_AP019739.1\|WP_141419275.1\|2748137_2748338_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_AP019739.1\|WP_141419287.1\|2772574_2773606_+\|DUF4974-domain-containing-protein	unknown	unknown	gnl\|CDD\|226235
NZ_AP019739.1\|WP_141419280.1\|2754364_2755498_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271185
NZ_AP019739.1\|WP_141419277.1\|2750420_2751806_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341205
NZ_AP019739.1\|WP_141419286.1\|2770390_2771269_+\|DUF4249-family-protein	unknown	unknown	gnl\|CDD\|379442
NZ_AP019739.1\|WP_008024682.1\|2779814_2781068_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271188
NZ_AP019739.1\|WP_019131622.1\|2744852_2747228_+\|BamA/TamA-family-outer-membrane-protein	unknown	unknown	gnl\|CDD\|227116
NZ_AP019739.1\|WP_141419282.1\|2756545_2757766_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340895
NZ_AP019739.1\|WP_141419284.1\|2766102_2766708_+\|peptidase	unknown	unknown	gnl\|CDD\|237816
NZ_AP019739.1\|WP_162502216.1\|2768262_2770383_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|366183

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141419276.1\|2748348_2750406_+\|N-6-DNA-methylase	gnl\|CDD\|372640	pfam13588, HSDR_N_2, Type I restriction enzyme R protein N-terminus (HSDR_N). This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.	4.64424e-33
NZ_AP019739.1\|WP_141419279.1\|2752589_2753711_+\|cell-filamentation-protein-Fic	gnl\|CDD\|225095	COG2184, Fic, Protein involved in cell division [Cell division and chromosome partitioning].	5.78402e-18
NZ_AP019739.1\|WP_141419288.1\|2773726_2777293_+\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_AP019739.1\|WP_008024684.1\|2777846_2778863_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271183	cd01182, INT_RitC_C_like, C-terminal catalytic domain of recombinase RitC, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	1.46926e-81
NZ_AP019739.1\|WP_019130946.1\|2771905_2772505_+\|RNA-polymerase-sigma-70-factor	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	1.97754e-44
NZ_AP019739.1\|WP_162502215.1\|2763640_2765677_-\|S8-family-serine-peptidase	gnl\|CDD\|173811	cd07485, Peptidases_S8_Fervidolysin_like, Peptidase S8 family domain in Fervidolysin. Fervidolysin found in Fervidobacterium pennivorans is an extracellular subtilisin-like keratinase. It is contains a signal peptide, a propeptide, and a catalytic region. The tertiary structure of fervidolysin is similar to that of subtilisin. It contains a Asp/His/Ser catalytic triad and is a member of the peptidase S8 (subtilisin and kexin) family. The catalytic triad is similar to that found in trypsin-like proteases, but it does not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	4.78547e-69
NZ_AP019739.1\|WP_008024683.1\|2778868_2779873_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271178	cd00797, INT_RitB_C_like, C-terminal catalytic domain of recombinase RitB, a component of the recombinase trio. Recombinases belonging to the RitA (also known as pAE1 due to its presence in the deletion prone region of plasmid pAE1 of Alcaligenes eutrophus H1), RitB, and RitC families are associated in a complex referred to as a Recombinase in Trio (RIT) element. These RIT elements consist of three adjacent and unidirectional overlapping genes, one from each family (ritABC in order of transcription). All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not yet fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism.	2.05496e-51
NZ_AP019739.1\|WP_141419275.1\|2748137_2748338_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	7.91789e-09
NZ_AP019739.1\|WP_141419287.1\|2772574_2773606_+\|DUF4974-domain-containing-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	1.6986e-28
NZ_AP019739.1\|WP_141419280.1\|2754364_2755498_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271185	cd01185, INTN1_C_like, Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain. IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	5.13009e-55
NZ_AP019739.1\|WP_141419277.1\|2750420_2751806_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341205	cd17524, RMtype1_S_EcoUTORF5051P-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli UTI89 S subunit (S.EcoUTORF5051P) TRD2-CR2 and Archaeoglobus fulgidus VC-16 S subunit (S.AfuORF1715P) TRD2-CR2. Escherichia coli UTI89 S subunit (S.EcoUTORF5051P) recognizes 5'... CCANNNNNNNCTTC ... 3' and the recognition sequence of Archaeoglobus fulgidus VC-16 S subunit (S.AfuORF1715P) is undetermined. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It also includes TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases, such as Pseudomonas putida Jo 4-731 Type IIG restriction enzyme/N6-adenine DNA methyltransferase (RM.PpiI), and type I DNA methyltransferases such as Bacillus cereus BDRD-ST24 M subunit of Type I N6-adenine DNA methyltransferase (M.Bce24ORF51270P). RM.PpiI recognizes 5' ... GAACNNNNNCTC ... 3'.	1.0802e-68
NZ_AP019739.1\|WP_162502216.1\|2768262_2770383_+\|TonB-dependent-receptor	gnl\|CDD\|366183	pfam00593, TonB_dep_Rec, TonB dependent receptor. This model now only covers the conserved part of the barrel structure.	1.0631e-15
NZ_AP019739.1\|WP_008024682.1\|2779814_2781068_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271188	cd01188, INT_RitA_C_like, C-terminal catalytic domain of recombinase RitA, a component of the recombinase trio. Recombinases RitA (also known as pAE1), RitB, and RitC are encoded by three adjacent and overlapping genes. Collectively they are known as the Recombinase in Trio (RIT). This RitA family includes various bacterial integrases and integrases from the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus H1. All three integrases contain a catalytic motif, suggesting that they are all active enzymes. However, their specific roles are not fully understood. All three families belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.80783e-68
NZ_AP019739.1\|WP_019131622.1\|2744852_2747228_+\|BamA/TamA-family-outer-membrane-protein	gnl\|CDD\|227116	COG4775, COG4775, Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane].	6.531e-30
NZ_AP019739.1\|WP_141419282.1\|2756545_2757766_-\|MFS-transporter	gnl\|CDD\|340895	cd17337, MFS_CsbX, CsbX family of the Major Facilitator Superfamily of transporters. The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.09061e-173
NZ_AP019739.1\|WP_141419284.1\|2766102_2766708_+\|peptidase	gnl\|CDD\|237816	PRK14788, PRK14788, lipoprotein signal peptidase; Provisional.	5.34999e-59
NZ_AP019739.1\|WP_141419286.1\|2770390_2771269_+\|DUF4249-family-protein	gnl\|CDD\|379442	pfam14054, DUF4249, Domain of unknown function (DUF4249). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 279 and 365 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.	2.6763e-22

>NZ_AP019739.1|WP_162502215.1|2763640_2765677_-|S8-family-serine-peptidase
MMKKILLLAGIVSLAACTNDPEETFSQGGGSSAGVKVIYDAEGAVEGQLIVKFRPSAADSLAAALASASATRAGFATADELLAAVGVDGIRPLFGSDPRFEERHRAFGLHQWYVVTFDESLPLREMVGELSHDGRIEVLEYARCPRLKNRFPARPLRSAAAAATRASMPMNDPLLPAQWHYDNTGYQVLVTQAGADVNLFDAWKKNQGSSDIVVAVIDQAVQYTHPDLQANIWVNPNPTKGDQHGYNFVNNTAELDWSYADRKEYQGQIYYSNADHGTHVAGTIAAVNDNDRGVCGIAGGRNGAGGVKIMSCQIFGDPDKRSYPTEDAFRYAADNGALICQCSYGYSYSTGSRDEMEAMRQWFMNSSEKAAIDYFIANAGKNDPDSPIEGGVVIFAAGNDGDLFGDVSEYPASYEAVVSVAAMGSDFLPAYYTCYNDEVDITAPGGDLYNSSLGTDNGGVLSTILSDPSVTYYDDERRQGLTDSNVYGYMQGTSMACPHVSGVAALGLSYLSQLGYRMTADAYKKLLLESVHPIDPYLTGTKRYDGPTLLLDEYKGKMGAGYLDANLLLENIKVAFGEKTPPRVTARIANRLLKTDTPTSSVALADYFTDDVVSQYDAVANDESVVRVNVSDGVLRMLPKKVGQARVTVSARGFEGTVVSQSFYVTVRSQSNSADGWL
>NZ_AP019739.1|WP_141419282.1|2756545_2757766_-|MFS-transporter
MTTFYDKTGLPKSLAWGFIGVLIFMMGDGIEQTWLSRYIASQGLDHEVLFTVYGISVALSAWFSGVIAETIGVRRTMLLGYLVYLVGMAGFAGIGMMGLNYPVMLVTYAIKGLGYPLFAYTFIVWIAYRVDKSRLSSAQGWFWFVFTGGLNVLGAYYGAYAMERIGVVPTLWSSLVFASVGAVLALWVNKCDDRNLFVGAERPSSGTSKFRELLSGLAIMKREPKVLVGGIVRVINTTSQFAFVVFMPLYLKDYGIGDTQWASIWGSIFLFNILFNLIFGIVGDHIGWGRTIVWFGGVGCAVSVLLFFYAPVICNNFWFILACGALWCIMLAGYVPLSALVPSLVDKDKGAAVSVLNLGAGLAAFVGPLIVALFRNAIGYVGIVWFMAGLYILSAVMTYCIAPRNR
>NZ_AP019739.1|WP_141419281.1|2755922_2756429_+|hypothetical-protein
MKLFHYLPVGVCAAAAALLLASCGVSKRSLKQSNRALTAALQASAQKEQAEALKLYSDTSIPQGEARKSVSRDNPGQTALEQTIIRWAIDSDPQGARVFYRVLSSIPAVVKNTNETYLMTTPYEETRAFNILGLTYENSRDVQIEIKVVKTGYEAQVKRFNVRQAIDQ
>NZ_AP019739.1|WP_141419280.1|2754364_2755498_-|tyrosine-type-recombinase/integrase
MPRVKKPAKVKEPIRLRMKELANGNKSLYLDIYRDGKRTYEYLKMYLIPETDNNARVRNQTTMAAANAIKSKRIIQLTNGEAGIETREKVFLLDWMETYKENQAKRGKKDGNQIQVTIRILKDYAGERVTMDQIDKAFCQEYIDYLLTEYRPKGKRVSNFTLHTYYRILNGALNAAVRAEIIKVNPFTKINNSDKIRLPESKRSYMTIEEVRALIATPMKNEAVKQAYLFSCFCGLRISDIISLKWKDVFVDRGQYRLAVSMQKTKESIYLPLSPEALKWMPERGEKTSEDHVFDLPSPTMINTLLKPWAKAAGIDKRFSFHTSRHTFATMMLTLGADLYTTSKLLGHADVKMTQVYAKIINQKKDDAVNLVNGLFD
>NZ_AP019739.1|WP_141419279.1|2752589_2753711_+|cell-filamentation-protein-Fic
MTNFDEYIRQGEPQKREKGYAWQTAIGLQAIDGLKPSDYLIETARKDIEGEITIDEAEQLIRSYYQSKIAHTPEDAEIHEADMASTNIRRLLTEKTFAFTLVGLTSIHRRIFDGIFKFAGQIRDYNITKKEWVLRGDTVLYVSAPDLRKAIEYDLEQERQFDYSKVDRNGLVSHIAKFVSGLWQIHPFGEGNTRTTAVFTILYLRSMGFDVTNDLFANHSWYFRNALVRANYQNVQKGIMRNSEYLERFFCNLLLGENNELRNRYMVVNAPEELTAKQVQQIDRTSTEQPAVQVTEQVRALLLALSNEQLSLKVLMEKVGLKHRPTFLENYISPASEDGFLKVLYPDKPNHPRQKYLLTAKGLALYNEIKKMQ
>NZ_AP019739.1|WP_141419278.1|2751820_2752576_+|hypothetical-protein
MKIIDLVAILGALAWLPQIISWIYHWLQKPMISVYHEEEAEVGFIKFGNAFNIRLSFLARRKHALIDNIELCITDKDGANHTFKWIWYSETLYELQAPTGNATMAKQQNAIAINAYKDVLIEKFIGFQSSSFLDRRKQLAYKLNSFIENQRTVGQIDADAIRRSNEYNELLRLYKNSMIWKTGDYSAICKIHIADTDTYMQHSFKFRLSDIEVETLKKNIEFARKIIDVEFINPQQQIEGTWLWTKPSIDI
>NZ_AP019739.1|WP_141419277.1|2750420_2751806_+|restriction-endonuclease-subunit-S
MEGLEIKEKKLYEVLSNKDFRIDSSFYTKEPKKNPDLIYAKIGEHLISSQYGISIEMNTDSVGYPIYRMNEIHDMLCDLDVDKCADITQAEYDRFALKDRDVLFNRTNSFEWVGRTGIYYQNDDIQRTFASYLVRLNPKDSILPEYLCAYLNCKYGEWDVKRRARQSINQTNVNPEEVKEIEIPILDIDLQQKIQCCFTQANSLRILSQKTYSEAELISHNELGINSIAVTDVNVSQKRFSDFINSGRLDAEYYQPKYDEIIGTISQYPYGHDKIGNLYILRDKNFLPNDNARYKYIELSDIGVNGEISGCTYDYGSNLPSRARRIVHTGDIIISSIEGSLQSCAIITEEYDGALCSTGFYVLSPRIINSETSLVLFKSSAIQALLKRACTGTILTAMNKDEFMAINLPVINKDIQNKIADIIRQSTILRSESKRLLNLAKTAVEIAIEQGENTAMKLLTI
>NZ_AP019739.1|WP_141419276.1|2748348_2750406_+|N-6-DNA-methylase
MKLYEILKGSEYSLDMFSQEVIAELENRIIERIDKKGKTYPVVSCLVRNKEIKLTPEEIVRQLYAAKLINDYGYPKSRLAFEYPIYFGRETKRADIVIRDNDDANVAYIIVELKKPKAKDGREQLKSYTHATGASMAVWTNGTTIAYYQRQNPNYFKDIPNIPNVHQTLEDILQTPFTMDDLVKNDKLTKTGKSLKDLILEMEDEVLANAGVDVFEEVFKLIFAKLYDEQIGATEKDYNLVFRNSGQSDIQLKNKIEDLFRKACSKWTGVFAKDAKIALTSPHLSICVSSLEGVKLFNSNLDVVDEAFEYLMSKSSKGEKGQYFTPRYVIDMCVKMLNPQVDETMIDTAAGSSGFPVHTIFHVWKQMQIAANKPVNHLFTATPKSHAEIEYVQDNVFAIDFDEKAVRVARTLNLIAGDGHTNVLHLNTLDWARWNTVTKEETWVDTYNDGFKKLKQLRVGNDFGQFNFAILMANPPFAGEIKEGQILSRYDLGMKNGKAQKSVSRDILFIERNLNFLKPGGRMAIVLPQGRFNNSSDKAIREYIAERCRILAVVGLHGNTFKPHTGTKTSVLFVQKWDDILCPKVDDYNIFFATQQKEGKNNSGDKLYWKSDKSGTTTDPKLALCDKYGHPIVYHDLLATVNYNWNKEKKCNEIEQITPDGIAEAFVEFAKKEQLSFFADAPLIK
>NZ_AP019739.1|WP_141419275.1|2748137_2748338_+|helix-turn-helix-domain-containing-protein
MDKPKNRIKEVLEEKGIKQIWLAEKLGKSFCIVNSYVCNRRQPSLDVLFEIANILHVDPKDLIISK
>NZ_AP019739.1|WP_019131622.1|2744852_2747228_+|BamA/TamA-family-outer-membrane-protein
MRRLYPIAVAALCILCTACSVVRKLPEGSYLVQKVTIEDDRNVPKKERITASELDRYVWQSPNKRFLGTNFYVWVYNQSNPDKDNWWNRFKRKIGEKPVVYDPALTLKSAENLKAYMESHGFFSSRVRYHVDTTSRRKRAIITYRTEQGPPSRYGKINYEFNDKFIEKIILQDTASTLIRPGGIFNSATLDAERERITRYLRDRGYYNFSVNNISYRYPYDTVGSRVGDLTMVVKQYLTGYNDRGEPVMENNKVYRISEINMLPGYDPTVSFTDREVRYDTVAYRGLNVVYDGKHNVRPRVLRQAIPLYPNYLYNAEQINRTYNNIMSLGYFKSTRITFDELPAPDSTNLVSYIGNADDSLATQYTQEGYLRCNILGTPQLKQSYKIDLEGTTTSSFYGLKASVGYQNRNLFRGMESFDIAFSIGHEFMKSRDSGKRNAKEFGVTAGLAFPRFLLPFFSSRYRPSLVTPRTRLELSFNYQDRPYYRRTLTSMTWTYSWSNEKYSSFAVRPVDLNLVDMSYINQDFFEKLQNLYLRNSYTSQLVAGISGSYTYNNQLKNPGRNATLVRFNWETAGNLIGGLEHLFSSPAKGKDYYEIFGIQYSQYFRVDLSASRKIMLGEKAAIAGRLYAGCGLAYGNSTSIPFDRLFYCGGSNGMRGWIPRMLGPGSVPVDPDKVTYPVQLGDMKLEANLEFRFPIWGIFHGATFFDVGNIWFMGNSAEEYPPEAVFHIRDFYKQLGFNTGLGIRLDIKFAVLRLDWGIQLHNPNNPAGKRWIHDFKWSNTALNFGVGYPF
>NZ_AP019739.1|WP_141419284.1|2766102_2766708_+|peptidase
MNFKKITILLLVLLVADQALKIWIKTHMTLDEAIMIVPTWFQLRFIENNGAAFGMRLATGGAFDWGKLALSLFRLAMIGLLGYYLRYLGKRKTPAGVLVGLTLILAGAIGNMIDSAFYGLIFSASTPTEVAHFGGSYAPLMMGRVVDMFYFPLFQWNGVPGWLSFLVDSRNYFFGAIFNLADAYISVAVVYLLIFQYKFFK
>NZ_AP019739.1|WP_019130949.1|2766811_2768197_+|hypothetical-protein
MKKILLCLALFCLATGPISCGDSNTDDGTEQGGGGNGGDGGGTGPEPEPGNPEITPEQHKAKLETIGKEVAAQFNPEDSKAAIESLTALEELLAFDDEDVAPSPAPKTYAVATAKSLAAVAAGPDVHALTSLIVRATTTEKYTLDEWAGDYVIEDGEPVKKGELANQYRLTWADAAGTQSEALFTYSAGGVEYTRVDGYAIVIPQDWNLSLKVAGHEELSVVGKSNVSADGLTLAPEVTVTLNGGYVAAAKVNADPKQVTANASFTKNGTQIVDAYAKMVCDGLTDPDNWIVEEEYDWNGDGVIDDTDTYIDPEDHIVDHVKTGEGYVTVMGLKLTLSGDIAKIIQQVNAIADTSTATGSQQEADAYNTNAKAKLAYTADNSTMADVKMQSYSYKDYIYVWNPDTQTGDNQVVTRYDIEPVLEFADGSKIAIEEYVETGFDSLTKTFEDLADAYMDLIDGK
>NZ_AP019739.1|WP_162502216.1|2768262_2770383_+|TonB-dependent-receptor
MTNTLTRLLLTAALCGLFLLSEAQERNAVSAPDPAAPRMPADSISRDYRLDGVVIGTQRPPSPLGSIAEGRFRLLMRNSSALPRFAGSIDPMRILQLMPGVQTAAEGNSGLYVRGNDAGQNLILLNQAPLYAHAHLLGFFSVFNPGQVASFELSKTGGGRIETAMQPATVVVQSREETGVRWGVEGDLGIIASQATVTAPLTDRAALFLSGRRSYTGWLIGALSPKGEDDLNYRLQDYDATLAWQIDDHNKLIVNSHYGDDRTHITYNEGLLGGRLQWYASVSSATLRSELSPTTHMENALYYSRLDTRLTASTTGISAQAPSSIGDLGYKHSTRWHIGRLQLAAGLQYAYRRIRPQHIASDYGGIADAGRGPRYDTHELAPFLAATIPLTHSLTCDAALRYGFYLLQGDGRIASYRHASPQPSLSLDWQVARGSRLRASYNYITQYIHKVPSSNISFSTDFWMAPTRRTPPQHTHHAALGYFAEAAGGRLNFSAEAYYQRMYRVLEYNAPLTGMVNNRYELEQYLHSGDGEAYGMEFMVSYAGRKFNGWISYTLGKSVRQFAALNDGLPFPASLDRRHDLSLAASYMPGERWELSTVFVYASGGAYTPTRDLYIAGGSFVRGHGSYNGARLPDYHRLDLSVTYWLRRKPWRSGINLSLFNLYAHRNPLYISWPVLVDEEKHEYQIHPRRHYLYTVIPSVSWIFKF
>NZ_AP019739.1|WP_141419286.1|2770390_2771269_+|DUF4249-family-protein
MKRSVILLFTLLGSCLGKVSTDTEYHRQLVVEGRIEAGGPAEVMLSENLPFLDVITEQTLEAAVVRYAKVTVTSDDGQSEILTGYYDRNYPTRFVYRSARLHGRTGGTYTLTVDYRGRTCTAVTTVPEPIPLRELRAEPVCDSLFTLQALFDDPPAKNAYFAECRTTDPGAYSPALMGVVDDSVLDNGGSVTLTVNRPLQYLKIKDYKQYFRPGETVDVRFSHISSPTFDFWSRLENEMLNAMNPVFPAYENLPSNIEGDARGIWSGYGSSYYRITMPQENDSKETTVFPPA
>NZ_AP019739.1|WP_019130946.1|2771905_2772505_+|RNA-polymerase-sigma-70-factor
MKAEESILIERLKKGERTAFNELYGIFWAPLVNYAELIVGDENADDVVQEVFVRIWVGRDKLRNDGSLRGYLLRAVYRTALNVLRSKNYASSYRSQTKLQIEQQLCTYYDPDENEIIRNLYARQIADELDAVVETLSPKCREVFRMSHFEGLSNREISERLNISVSTVENHINNALRQLRGKLGHLKMFLLLTIYILGQ
>NZ_AP019739.1|WP_141419287.1|2772574_2773606_+|DUF4974-domain-containing-protein
MKNEDSQHPFNERIIWKYFDGTATSEEEQELSQWLATSEKHRREVAELRAVRQRFAKWRSTLYGPARFIRSLNRLNSRIDALENAPCTVQRPHRLSNLFGHIRIHSLLRTAAVVAVVALTGMFAWRTALMLAPITYFNADTTIMHVAMPDGSDIWLTPGSTLCYDETFHTDERRVHLDGEAYFDVEHDAKHPFDVVTPNLRVRVLGTVFSVRSLRGDHMAETTLAEGAVSLQRADGSNLIRLHPGQRAIYDTQDEQLEIKEVPVGDHLALSYGIITLDGVPLRQIADRIEELYGVKLRLVDDDAPDANYNFSFQKDTPIEDVIELLQFISGTRFEILRYPDSD
>NZ_AP019739.1|WP_141419288.1|2773726_2777293_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKKIGLFLTGWCRMLLCVGLAALPSASLGARGELLADQRLNLNLSFDSASLREVVSAFTEQTGVVFSYETSLGKRTLSDVHVVIQDAPLEEMLNTLFYDTGISWKIKDHVVALTAIPSSKKNVSTGSAPSPSANRKPVVTGRVVNEEGEPLVGVNVLVKGTTQGTSTDIDGSYSIAVADDDVLQFTYLGYGSAEWRVGTQTRIDVVLKEDKQMLDEVVVVGYGTVKRRDLVGAVDQVDSKVFSERSNPSISRSLQGAIPNLNISMRDGKPSRAATINIRGTGSIGSGGGALVLIDGVEGDLETVNPQDIASVSVLKDASSAAIYGARGAFGVILVTTKSAEEGETKVTYNGSFSLHARTVKPQLVTDGYEWTTGYINAWNGYYNGQNPLPSYINNIAPYSDSWYKELARRSTDPSLERVRINDKNQYEYFANTDWMDAFYKDFNYSHEHNISVSGGNQNADYYVSGRFYDQDGIYRVGDERYKQYNVRAKGNIRIRPWLRLNNNMDFTVVDYHQPMLYYSLQLPQRMIEHGGQPINPITNPDGTWTYAAVLNGYAGFAEGSSYQQDDKFTMKDKLGIEIDVVKDVLKISGDLSYLFARNKRERVTNMYTGYRGPDTPITVNESQGSTLENLRQDTNYLSSNIYGEYTPKLGDDHTLKLLAGWNLETKKYRGTTIKREGLTVPSKPSFGLMDGLTSDPVVSGYDWSYVGAFFRANYGYQGKYLAEFSCRYDGSSKFPENSKWGFFPSASIGWRLSEEKFMEWSRNWLDNFKIRLSAGSMGNGNIDPYKYIDYMTIKTSTVVIGDALGSYTTAPGAIPLSLTWETATTYDVGFDMDLFRNRLSIGFDWYRRYTTDMYTVGVSLPSVYGTDAPKGNNASLKTNGWELSVGWRDSFELGGKAFSYNVKAMVWDARTWVTEYINPTGALGDYYEGKELGEIWGYRVEGLFRDQEDIDSHAEQSFLQTLDKVTRPGQVKFADLNQDGKIDRGAYTTADPGDLTVIGNETPRYCYGINLGFNWNGIGISTFWQGVGKKDWYPRYDSGFFWGQYNRPFGYMLKQHTGDKVYREELDNWDTAYWPRYTTYQTHQSSVNRPLTINNDRYMQDVSYIRLKNITVDYTFPDRICKKLHIKGLKVWVSGENLWTYSPMFEHCDNYDPEVINAGDSDFRTSEGDGYSYPMLRTVTLGVNLSF
>NZ_AP019739.1|WP_008024684.1|2777846_2778863_-|tyrosine-type-recombinase/integrase
MKPTNFSKYLTDFLLRYLPHERGASTNTIHSYRDTFTLYLVYMESKGVKAEKLTMESITKENILSFLDWLETKRSCCTSTRNLRLAAIQSFFKYLQYQSSDHLYEYQEIMAINNKKSVKPIMNYLTVEEMKILLQQPDTTKPKGRRDLALLSLMYDTACRVSEVISLTPQCVRLDEPYTVIITGKGNKNRVVPMLEEQLDILKIYMKENGLLRSECLQHPLFTNCWGEKLTRAGVANILDRYIKKAKLLHPTLMKGKISCHSLRHSKAMHLLQAGVNLVYIRDILGHVNVQTTEIYARADSKVKREAIEKAYIKVVQEVDTKPMWQGNEKLMDFLKSF
>NZ_AP019739.1|WP_008024683.1|2778868_2779873_-|tyrosine-type-recombinase/integrase
MYHLYVKTFIPRKEAIFMNRNFKGIYASLIREFVSLKRSMGFKYIGGEFVLTLFDRFTIERNETAIGITKELSDAWCKERDNESNSYHYRRCYILGAFSSFLNKKGIRSYIPRTPSLRNTFIPHIFSSKEIERIFTTCDNMQSGNNDMRSSFFIMPSLLRMLYGTGIRIGEALSLLNEDINLEEEYFILRDTKNGKDRIVPFSTSLAEVLKDYVVHRNRLPVKISDTTPFFITLKGRACDRDSIYRRFCKILIQANIPKDRIRLHDLRHTFAVHSLAKMAEEGMDLYCSLPILSTYLGHQSLRATNNYVRLTSEMYPELIRKIDIIGFDIFPKM
>NZ_AP019739.1|WP_008024682.1|2779814_2781068_-|tyrosine-type-recombinase/integrase
MNDHSTTFEAVTSSMLKILKEDFSRTDSTLEGYAWKWNQLRQFMENNDLHSLTPKVCDDFLSSLYGSKDLTSLKSGDKKFLSAILLLKNYLITGQVIPRKVPVELKGEIGSLMMQYILSRSQERLSGHTIYNHKQIFHRFLDFLTSAKVASIEQVEITHIIKYLNTIGTKYKSVASISIHILRNFFRYLYEHKIIDMDLAAFIPKDNYKKQPKLPSAYTSEEIKKIVSSVDRSTTTGKRNYSIILLATMLGLRASDIANLKFENILWEDNAIRLIQHKTNKELELPLLPEIGNAIIEYLRYGRPKSQSSYIFLLARSPYTHINQPVISQIAKKYFLKANVNIKNKHHGAHALRHSLATLLLEEQVKLPVISEVLGHENTESTSYYLRIDIQSLKKCSLDVSPVCENFYTQKGGYFYE

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Crispr_ID: NZ_AP019739_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_21

3069064-3069184

Orphan

Consensus_repeat	Method
AACGTTTTCGTTAAGCCAAATGGGCAGAGCCGCGCTTACGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_21

>merge|NZ_AP019739|21|3069064-3069184|CRISPRCasFinder
AACGTTTTCGTTAAGCCAAATGGGCAGAGCCGCGCTTACGCGAACTATGCCATGGCGAGAAAACGAAGAATGAAATTCAACGTTTTCGTTAAGCCAAATGAGCAGAGCCGCGCTTACGCGA

>NZ_AP019739|21|20|3069064-3069184|CRISPRCasFinder
AACGTTTTCGTTAAGCCAAATGGGCAGAGCCGCGCTTACGCGA	ACTATGCCATGGCGAGAAAACGAAGAATGAAATTC
AACGTTTTCGTTAAGCCAAATGAGCAGAGCCGCGCTTACGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_141419486.1\|3076068_3077742_-\|ribulokinase	unknown	unknown	gnl\|CDD\|235221
NZ_AP019739.1\|WP_141419479.1\|3064391_3066218_+\|YgiQ-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|274847
NZ_AP019739.1\|WP_019130785.1\|3079827_3081099_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP019739.1\|WP_019130786.1\|3079261_3079702_-\|PepSY-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|371505
NZ_AP019739.1\|WP_141419483.1\|3069822_3070896_+\|porin	unknown	unknown	gnl\|CDD\|369347
NZ_AP019739.1\|WP_141419478.1\|3063014_3064100_+\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801
NZ_AP019739.1\|WP_141419474.1\|3060060_3060948_+\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_AP019739.1\|WP_141419484.1\|3070964_3071870_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197317
NZ_AP019739.1\|WP_141419487.1\|3078212_3079103_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_AP019739.1\|WP_141419481.1\|3068301_3069027_+\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|234622
NZ_AP019739.1\|WP_141419485.1\|3071873_3073244_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_AP019739.1\|WP_019130789.1\|3074754_3076053_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_AP019739.1\|WP_019130798.1\|3066363_3067260_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|274043
NZ_AP019739.1\|WP_141419480.1\|3067371_3068199_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NZ_AP019739.1\|WP_019130805.1\|3057307_3060061_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|178177
NZ_AP019739.1\|WP_141419475.1\|3060950_3061823_+\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_AP019739.1\|WP_141419476.1\|3061896_3062274_-\|DUF2023-family-protein	unknown	unknown	gnl\|CDD\|378227
NZ_AP019739.1\|WP_141412409.1\|3073370_3074732_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_AP019739.1\|WP_141419477.1\|3062287_3062782_-\|flavodoxin	unknown	unknown	gnl\|CDD\|236439
NZ_AP019739.1\|WP_141419482.1\|3069210_3069687_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141419486.1\|3076068_3077742_-\|ribulokinase	gnl\|CDD\|235221	PRK04123, PRK04123, ribulokinase; Provisional.	0
NZ_AP019739.1\|WP_141419479.1\|3064391_3066218_+\|YgiQ-family-radical-SAM-protein	gnl\|CDD\|274847	TIGR03904, putative_radical_SAM_protein_YgiQ, uncharacterized radical SAM protein YgiQ. Members of this family are fairly widespread uncharacterized radical SAM family proteins, many of which are designated YgiQ. [Unknown function, Enzymes of unknown specificity].	0
NZ_AP019739.1\|WP_019130785.1\|3079827_3081099_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.72391e-34
NZ_AP019739.1\|WP_019130786.1\|3079261_3079702_-\|PepSY-like-domain-containing-protein	gnl\|CDD\|371505	pfam11396, PepSY_like, Putative beta-lactamase-inhibitor-like, PepSY-like. This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.	1.07683e-29
NZ_AP019739.1\|WP_141419483.1\|3069822_3070896_+\|porin	gnl\|CDD\|369347	pfam07396, Porin_O_P, Phosphate-selective porin O and P. This family represents a conserved region approximately 400 residues long within the bacterial phosphate-selective porins O and P. These are anion-specific porins, the binding site of which has a higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates, while porin P has a higher affinity for orthophosphate. In P. aeruginosa, porin O was found to be expressed only under phosphate-starvation conditions during the stationary growth phase.	3.01983e-16
NZ_AP019739.1\|WP_141419478.1\|3063014_3064100_+\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NZ_AP019739.1\|WP_141419474.1\|3060060_3060948_+\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	1.04378e-26
NZ_AP019739.1\|WP_141419487.1\|3078212_3079103_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	4.13913e-16
NZ_AP019739.1\|WP_141419481.1\|3068301_3069027_+\|DNA-repair-protein-RecO	gnl\|CDD\|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	8.24947e-14
NZ_AP019739.1\|WP_141419485.1\|3071873_3073244_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.95038e-132
NZ_AP019739.1\|WP_019130789.1\|3074754_3076053_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.11058e-56
NZ_AP019739.1\|WP_019130798.1\|3066363_3067260_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|274043	TIGR02225, Tyrosine_recombinase_XerD, tyrosine recombinase XerD. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	2.0093e-127
NZ_AP019739.1\|WP_141419480.1\|3067371_3068199_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	4.44937e-72
NZ_AP019739.1\|WP_019130805.1\|3057307_3060061_+\|leucine--tRNA-ligase	gnl\|CDD\|178177	PLN02563, PLN02563, aminoacyl-tRNA ligase.	0
NZ_AP019739.1\|WP_141419484.1\|3070964_3071870_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197317	cd09083, EEP-1, Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.	1.69148e-78
NZ_AP019739.1\|WP_141419476.1\|3061896_3062274_-\|DUF2023-family-protein	gnl\|CDD\|378227	pfam09633, DUF2023, Protein of unknown function (DUF2023). This protein of approx.120 residues consists of three beta strands and five alpha helices, thought to fold into a homo-dimer. It is expressed in bacteria.	3.43161e-58
NZ_AP019739.1\|WP_141412409.1\|3073370_3074732_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	3.52414e-132
NZ_AP019739.1\|WP_141419477.1\|3062287_3062782_-\|flavodoxin	gnl\|CDD\|236439	PRK09267, PRK09267, flavodoxin FldA; Validated.	5.67087e-62
NZ_AP019739.1\|WP_141419475.1\|3060950_3061823_+\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	1.15094e-31

>NZ_AP019739.1|WP_141419481.1|3068301_3069027_+|DNA-repair-protein-RecO
MKSYKARGIVLHTLKYGDSGMVVYLLTDSGGRQSYMVQGVRSARGHGSKLALFQPMFAVEFEGLESSRMQMHRFREVRSGIVLQSLPFDVRKSTIALFMAEVLYRLVKECEPNQRLFDFVWGSVAALDALDEGVANFHLWFLTNLSRFLGFSPGNAYLPGAWFDIREGSFTPLRPSHGEMLSTDDARILHDLLECDVRYIAEIGLNRRQRVAYLDALLVYYGYHLDAIHAVQSVRILQEVF
>NZ_AP019739.1|WP_141419480.1|3067371_3068199_+|50S-ribosomal-protein-L11-methyltransferase
MDYIELTLDAADAEQAEILTAELADFPFESFEQEGARLKAYIPQERLADCKGEVDALLARYGVGRATFLSIEPQNWNALWESNFTPVEVDGRLTIRAPFHAPAATEAEVVIMPKMSFGTGHHATTCLMASGLLDRDVTGLRGLDMGSGTGVLAIVAALRGAETVDAVDIDEWAYENCVENIRANGVETRVTPLLGDIGAIAGRRYDFIAANINRNILLAQLPAYAAALDAGGWLLMSGILEADVAPLSEAARAAGFSVTGHALRDGWARVDAVKN
>NZ_AP019739.1|WP_019130798.1|3066363_3067260_-|site-specific-tyrosine-recombinase-XerD
MAENSRRWAEISRRYRTYIKLEKRLSANTVESYMRDLEQFAHFVLRMWDVPPRKVESQMIERYMAWLYDRGCEKSSQARALSGLKSFFNYLLLTDAIESSPLEFIEMPKFSRRLPDVLSTAEIDRILAAIDRTTPKGVRDDAMLELLYSCGLRVSELISLRLCDLFFGEGYIRVIGKGDKQRLVPVSDTAREKIYAYLDCRKGGSSSEETLFLNNRGGRLSRVMIFTIIKQAVLRAGIDKQVSPHTFRHSFATHLLEGGASIRQVQEMLGHENIITTEIYTHLDNEHLRETVERHLPI
>NZ_AP019739.1|WP_141419479.1|3064391_3066218_+|YgiQ-family-radical-SAM-protein
MAFLPTTVKEARQRGWDSVDVVLFTGDAYIDHPAFGAAVIGRLLEAEGYRVAVVPQPNWRDDLRDFRKFGTPRLFFAVTAGAMDSMVNHYTANKRLRSNDAYTPGGAAGFRPDYAVETYTRILKRLYPRTPVVVGGIEASLRRLTHYDYWQDALKPSILVDSGADLLIYGMGERVVQQVAAAMRNGYNAKLLRKLRQVAFLADRTYVDRLEDRLLLHSYEECTADPHAFAENFRRIETESNLMEPHSVLVEPTGDRYVVVNPANATLSTEELDRSFDLPYERAPHPRYRGKGDIPAWEMIKHSVNIHRGCFGGCAFCTISAHQGKFIHSRSERSILDEVRRIAAMPDFRGYLSDIGAPSANMYRMGGRDRTLCARCRRPSCLYPRICPNLDNDHRPLLDLYAKIRAVKGIKKAFIGSGIRYDLFDGSDYLETVVRHHTSGRLKVAPEHTEERVLALMRKPPFALFERLNDDFRSICRSNGLNYQLIPYFISSHPGCTERDMQALAGKVLGRLHFTLEQVQDLTPTPMTLSSVMFYTGENPYTGEKVYVARSQEEKRRQKGYFFRTAESGARPPQGRRTTAPKGVGRDSDTGKRDVRRSAPPHGKSRKR
>NZ_AP019739.1|WP_141419478.1|3063014_3064100_+|peptide-chain-release-factor-1
MADNSILQRLDGLKLKYEELGQKLTDPEVIADVKQFVQLNKDYKELEPIIETSERFRTALANLAEAKDVLANDKDEEMREMAREEIAELEPAIVRMEEEIKLLLIPKDPQDSKNAIMEIRGGTGGDEAALFAGDLFRMYTKYIESKGWRYEVTSFSEGTAGGYKEVVMKVTGQNVYGTLKYESGVHRVQRVPVTETQGRVHTSAASVAVLPEAEEFDVEISMNDVRKDIFCASGPGGQSVNTTYSAIRLTHIPTGIVVQCQDQKSQLKNFDKAFEELRTRVFNLEYSKYLDQIASKRKTMVSTGDRSAKIRTYNYPQGRITDHRINYTIYNLAAFMDGDIQDCIDHLIVAENAERLKESEL
>NZ_AP019739.1|WP_141419477.1|3062287_3062782_-|flavodoxin
MRTGIFYGSTTGMTESLAAKIAARTGVAQTDVHNVADASADEAEGYDLLLLGSSTWGCGELQDDWYDFLDALKRKALSGKRVALFGCGDRASYPDSFCDALAEIRDGLEATGCTFVGALDAAEYDGCTSRICRDGKVIGLAVDDGASEAVNDARMEKWIAAVGF
>NZ_AP019739.1|WP_141419476.1|3061896_3062274_-|DUF2023-family-protein
MSADDFNRHTDLKMLLHHIYEFQKGVRRLVLCTICPTCARLVAERLQARRIDYLVQPVTADKVNLYFGHRACLDAVRMFVHKPLNELSAEEDFMLGVMLGYDLPMQCERYCTRKRRPLPAVGAGG
>NZ_AP019739.1|WP_141419475.1|3060950_3061823_+|alpha/beta-hydrolase-fold-domain-containing-protein
MKRLLTLVALAATLTASAQVKVVKLWDNASAPHSNEDAGPQKEKNGNLYNTVDTELFIYPAAPDKATGQAVVVCPGGGYRFVSMPREGHEVGEWLSAEGITVVALKYRLPNGHCQVPLEDAEAALRYIRDHAAEYGVDPSRVGIMGFSAGGHLAASAATMLPEEVRPAFAVLVYPVITAEPGKCHKGSFDNLLGTDRTAGDEAQWSLQNRVTASTPPTLLLLADDDRTVPPVNSTLFYEALKRNGVKGCSLRIYPSGGHGGGFNPDRIYRTAWRADVLDWLGTLPNSASH
>NZ_AP019739.1|WP_141419474.1|3060060_3060948_+|alpha/beta-hydrolase-fold-domain-containing-protein
MRRLLVLTALAAALTAGAQQRIVRLWNNASAPHDNGLRGGERVEEDRLFNTTEAVLYVYAADPARATGQAAVVCPGGGYRFLSIGGDGHAVGRWLAEHGVTAAVLKYRLPNGRCEVPLEDTEAALRYLRRTAPDFRADSAQVGIVGCSAGGHLAASAATMLPEEVRPAFAVLIYPVITAESGKCHKGSFDHLLGTDRTAGDEAQWSLQNRVTASTPPALLLAADDDRSVPPVNSVLFYAALKRHGIPASLRIYPSGGHGGALDPAHIYRAQWRADILDWLAMLAHEDQKPTSKPR
>NZ_AP019739.1|WP_019130805.1|3057307_3060061_+|leucine--tRNA-ligase
MEYNFKELEPKWQQRWRERGTYHVEVDPARPKYYVLDMFPYPSGAGLHVGHPLGYIASDIFSRYKRQCGFNVLHPMGYDAFGLPAEQYAIQTGQHPAVTTEHNIARYREQLDKIGFSFDWDREVRTCDPGYYKWTQWAFLKMFGSYYCRDRQQARPIGELEEAFARSGTEGVNAACTAELHFTAADWAGMDEHRREQVLQNYRLAYRADTMVNWCPQLGTVLANDEVKDGLSVRGGYPVVQKRMKQWLLRVTAYAQRMLDGLETLQWSESLKEIQRNWIGRSEGAQVFFDVRGFDRKLEIFTTRPDTIFGVTFMVIAPEHEWVNELTTPENKTAVEDYLEQTQKRSERERIAETRRVSGVFTGSYAVNPFTGREIPIYISDYVLAGYGTGAIMAVPAHDSRDYAFARHFGLEITPVVAGGDISKESYDAKEGKLINSGFLDGMEVREAIGKMFDAIEQRGLGKRLVNYRLRDAIFSRQRYWGEPFPIYYRDEIARPLPESALPLELPPVSDFGPTEEGEPPLARAAGWTTADGDPLELSTMPGFAGSSAYYLRYMDPHNDRALVGREADEYWRSVDLYVGGIEHATGHLMYSRFWNMFLYDLGCVCEPEPFRKLVNQGMIQGRSNFVYRVVGTNKFVSFGLKESYETQEIHVDVNIVRNDQLDLDAFRAWRPEFADAEFILEDGKYVCGWAIEKMSKSMFNVVNPDYIVDQYGADTLRMYEMFLGPLEQSKPWDTNGIDGVHKFLRRFWRLFHAGDALAVTDEAPTPKELKTLHKTIKKVREDIENFSFNTSVAAFMICLNELGECRKRAILEPLVALLAPFAPHIAEELWERLGHTASVCDAPYPVCDESYLVEQSFEYPVMINGKLRFKQEYALTASPDEITADIVARPAAQKWLDGKAPKKVIVVKGKIINIVL
>NZ_AP019739.1|WP_141419482.1|3069210_3069687_+|hypothetical-protein
MKTNLFLSILFLLAAGVAGAQEPPVTEAEIERQEQQRARETTEQRVEQAVEGELQELLERIPDSLRVDKWIPGTVVVDGHILEPVPLHKPEMERWSMPRQQQVTPIERDFVRRLTSGWLAVSNGQAFNWEYGRRIWGVGSIYPGSYLDARTLSFPLPR
>NZ_AP019739.1|WP_141419483.1|3069822_3070896_+|porin
MKRLLLALAVTAGLFPTTRGAAQQRDSLAATVERLSAEIETLKGRSAAADRILSRLPRISGYLQLGYEWSDDASTFFVKRARVNFQGDISPKIDYRLQLEFASPKIVDIYLRYKPLEALNVQVGQFKVPFSIENTHYVPLKYEFIEYSMAVCRLMGFTDVCGVNATGRDLGAQLYGGLIGRDGYSILNYNVGVFNGEGINIKDKNKSKDVVVRLMVQPLRALSFAGYYYWGEVGADYARRTRYGGGVCYDDGRWIARGEYIAGRTGIVSPDVAEPFDSRGYYAMAACWVTPKWLPAVRFEQFDEVAGRSASRQTNYTAGVTWQPFKHLRCQLNYTYEQYGGTNPDRNVVKAMLTGIF
>NZ_AP019739.1|WP_141419484.1|3070964_3071870_-|endonuclease/exonuclease/phosphatase-family-protein
MFRRILIITGVLLSLAGTAEAGEKAESDDDIHRVMTCNIRITGLEADASYSERVWENRRDLCVETILSRRPDIICLQEVIYDSYAYLKEKLRGYVPYGFAGPEMDPYTEGYHFIGKNVIFFRRDRYEFVSAGCYWLSETPLIGGSCSWNTTRARHCNWVRLRDKRSGRELRVLDVHLDHKSDEARREQIRMVMDECAQYAPDFPQILCGDFNAGIDSAPIGYIRTVDGWREMYESVHGPGETGFTAHAFKGEEYKPEKSHRIDFIFYRGDVEVCDAEIVRDRKGAMYPSDHYFLFSEFTLR
>NZ_AP019739.1|WP_141419485.1|3071873_3073244_-|FAD-dependent-oxidoreductase
MKQIEEPARRIPVRAEVDVLVVGAGPAGLMAAQAAALEKGTKVMLVESRGFLGGNMTIGLPLLGFLGRKGNVVIKGLPLQFVERLQEKGLATHHRACPLHVSLTMIDPEGTKHLAFQIIKECGIDLLMYAFATDVIMEGNTVKGVIIDSKKGREAILAKRVIDCTGDGDIAYRAGAPMNYGNEKGIPQPPTLMFSMRGVDSRKLRDAVADHPDVYDIDFIPNEFFRADDNCTFVGFRNQIKKAREAGYKLPVERTIFMTGMAPDEWWVNMSRVNGIDATDPAQYTQGEIICAEQNEEIVRYLKAYIPGFENAYVDRVAPFMGIRETRRIVGEYILTEDDIFNCARFDDVIAVASYPVDLHHPVGGDCSLYWCPDCYDIPYRCLIPQKIDGLIVAGRNVSMTHLALASARVMAPAMALGEAAGKAAALSVKENVELRDLDVRKLQESLKAEGVYFRE
>NZ_AP019739.1|WP_141412409.1|3073370_3074732_-|FAD-dependent-oxidoreductase
MKTIKEPARDIPVRAEADVLVVGGGPAGIMAAEAAAGDGLRVMLVESRGFLGGNLTIGLPILGFLGRKGNQIIEGSAQRFIDRLRARGAASEHRPCKNHMSLTIIDEEEVKRTALEIMEEKGVEVLLYTFFADAIREGDAVKGVVVESKAGREAILAKTVIDCTGDGDVAFRAGVECRKGDAEGGMQPPTLMFCMKGVDVQRLRDAIVGHPDVYDMDVMPPEQFRTGKFITVGLRTQIRQAQAAGYRIPVARTILITGLADDEIWVNMTRVSGVDSTRPESYTYGEIEGRKQIYEIARYLREFVPGFADARIEKVAPFMGIRESRVIVGRYVLTAEDIIACRRFGDAIAVAGYPVDIHHAKGGDCTMHFCDDSYDIPYRCLLPERVAGLLVAGRCSSMNHEAMASTRVMSTCMALGEAAGRAARLALKAGVQPADLDVEALRAELRATGAYLG
>NZ_AP019739.1|WP_019130789.1|3074754_3076053_-|MFS-transporter
MNLLKDPNKRKWVIVATMFIAIICNYLDRQLLSILKPEILEHFGIGDMQYAWIVNVFLICYALMYPVSGILVDRFGPKRVMLAGIAVWSLACIGGGLAQTVWQFAVCRGILGLAEPTIFAGQLVAVTLWFEKRQRATANSLCTVGGSLGAVIAPLVIAWLMRWFSNWQEVFLVAGVAGLVIAGLWMVVYRTPSQEILDRTVNVDRMTSSGEEQKSFTLGGLFRTRTLWGAFLIRLISDPVWYFCCFWLPGYLRGMGEAQNLTHEQTLNMIQWIGGIPFLVGALGGILTSVWSDSMIKRGRSALSARKVMLMAVVVVAPLCAAVPYVGASETLSFAWRVGLVVAIFSLVAVMCLSWLYTLPVVLAETFPIKNVASVMGICCGAGALGSVVFNQFVGSIPSEAWYTLFAIMGTLHIIAAVVLWKMVRPESPETK
>NZ_AP019739.1|WP_141419486.1|3076068_3077742_-|ribulokinase
MEHAYVIGLDYGTDSVRALLVDALTGREIDSEVALYPRWNKGLYSDPRVARFRQHPKDYLEALRQAVRAVTGRHADLAPYVRALSVDTTASTPCLTDRAGVPLSLHEEYAENPDAMFVLWKDHTGQAECEEINALCARSEINYACHSGNYYSAECFWSKVLHLLRRDEALRRDAWSVVELCDWIPAVLTGCPDAASVKMGHCVCGSKLMWAEEWGGYPPEKFFAELDPVLLPVLHHLPNVNYGCDVAAGTLTGEWASELGLPAGIPVGVGCIDSHSGAVGAGIRYGTVVLNLGTSACYMAVMPPEAMGDKIVEGIFGQVDGSILPRMIGFESGLSAFGDVYAWFKRLLCWPLREILARTELVDAPTRDRLIAETEAGIMDALTQGAAALPLRADAPLATDWLNGRRSPFADSSLTGTLTGLNLSTSAPEIYYAFAEATAFATKHILDHMRDNGVRIDRLIGVGGIAQKSPFVMQLLADTTGMRIDVSDCKQAGAMGAVVHAATIAGLYPSVTEAQQALCAPASRSYVPDVSRQAVLNERYARYRAVGAFTERLKNNR
>NZ_AP019739.1|WP_141419487.1|3078212_3079103_+|EamA-family-transporter
MNNPKGIAYAALSSSTFGLAPLFTVTLLRDGFSPFEVLTYRWGVASAALLLFGLATGRRLRIARRDFGVVFLLSLFRAGCSLSLVFAYANIATGVASTIHFLYPLAVALAMTLFFRERCSRRLFTAIAVSLAGAALLSSGDIRSNGGDATFGIAAAFFSVISYAGYIIGVRKSRAAQVESTTLTLLVMAIGAALFAATGSLTSGLHWVDDSRTWGNILGLAIPATAVSNIALVKAIKAIGPTLTSILGAMEPLTAVLIGVLHFGEPFTAAGIAGVVLSVAAVTIVVTQGGKPAGNA
>NZ_AP019739.1|WP_019130786.1|3079261_3079702_-|PepSY-like-domain-containing-protein
MKKLLILAAAVFALGTSTVSADNDRPISVSELPEKAQQFIRQHFPNEKVSFAKMERELFDTTYEVIFTSSSKVEFLKNGDWKEVDCKYSTVPAAIIPQQIAQYVSQYYPDTSVVQIDRDKRDYEVKLTNGLELTFDLKFNLIDIDD
>NZ_AP019739.1|WP_019130785.1|3079827_3081099_-|HAMP-domain-containing-histidine-kinase
MKLISRIALRLSLALLPLMALWGVLFYFTMVDEINDEADDALEDYSELIVKRMLAGRELPKPNNGSNNSYSIVPIGAPEAAVRPHIDYYDAEVYIPEKEETEPARVLTTIFQDADGAYYELKVATPTFEKDDLLRAILYWVVFLYLLLLLTTISLTVWVFHRSMRPLYELLRWLDDYTPGRRGAPVPCSTRIVEFRRLSAAAQQAVDRSEALFEQQKHFIGNASHELQTPLAVLGNRIEWLLDNTEPTEKQMEELLKMQRTLRQIVRLNKTLLLLTKIDNGQFPESSEVDLAAVVGEQVALYDEIYAGRGIACTVSAPEAFVVRMNESLASTLVTNLLKNAYLHTAEGGAVGVELRDRTLTVTNDGTAPLDAEHIFERFYQGARKEGSTGLGLALVSAVGRYYGLRIDYRFEGGRHRFSVRWP

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Crispr_ID: NZ_AP019739_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_22

3078026-3078143

Orphan

Consensus_repeat	Method
CTTTGGCTGGCGCCTTAGATACTCCCGTTCGGCAGAACCAAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_22

>merge|NZ_AP019739|22|3078026-3078143|CRISPRCasFinder
CTTTGGCTGGCGCCTTAGATACTCCCGTTCGGCAGAACCAAGCTAGCGCTTGCTTCTGCCCTTGACTTTTCGTATCTTTGGCTGGCGCCTTAGATACTCCCGTTCGGCAGAAGCAAGC

>NZ_AP019739|22|21|3078026-3078143|CRISPRCasFinder
CTTTGGCTGGCGCCTTAGATACTCCCGTTCGGCAGAACCAAGC	TAGCGCTTGCTTCTGCCCTTGACTTTTCGTAT
CTTTGGCTGGCGCCTTAGATACTCCCGTTCGGCAGAAGCAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019130770.1\|3087124_3087544_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419486.1\|3076068_3077742_-\|ribulokinase	unknown	unknown	gnl\|CDD\|235221
NZ_AP019739.1\|WP_019130785.1\|3079827_3081099_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_AP019739.1\|WP_019130786.1\|3079261_3079702_-\|PepSY-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|371505
NZ_AP019739.1\|WP_141419483.1\|3069822_3070896_+\|porin	unknown	unknown	gnl\|CDD\|369347
NZ_AP019739.1\|WP_141419481.1\|3068301_3069027_+\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|234622
NZ_AP019739.1\|WP_141419487.1\|3078212_3079103_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_AP019739.1\|WP_141419485.1\|3071873_3073244_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_AP019739.1\|WP_019130789.1\|3074754_3076053_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_AP019739.1\|WP_019130798.1\|3066363_3067260_-\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|274043
NZ_AP019739.1\|WP_019130784.1\|3081147_3081834_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_AP019739.1\|WP_141419480.1\|3067371_3068199_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|234786
NZ_AP019739.1\|WP_141419489.1\|3083797_3084634_+\|YchF/TatD-family-DNA-exonuclease	unknown	unknown	gnl\|CDD\|238635
NZ_AP019739.1\|WP_141412436.1\|3084947_3085988_+\|type-I-asparaginase	unknown	unknown	gnl\|CDD\|199207
NZ_AP019739.1\|WP_141419484.1\|3070964_3071870_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197317
NZ_AP019739.1\|WP_141412437.1\|3086282_3087095_+\|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl\|CDD\|223881
NZ_AP019739.1\|WP_141419488.1\|3082613_3083711_+\|DNA-processing-protein-DprA	unknown	unknown	gnl\|CDD\|223829
NZ_AP019739.1\|WP_141412409.1\|3073370_3074732_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|378963
NZ_AP019739.1\|WP_141419482.1\|3069210_3069687_+\|hypothetical-protein	unknown	unknown	unknown
NZ_AP019739.1\|WP_141419490.1\|3084630_3084933_+\|TIGR04076-family-protein	unknown	unknown	gnl\|CDD\|274964

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141419486.1\|3076068_3077742_-\|ribulokinase	gnl\|CDD\|235221	PRK04123, PRK04123, ribulokinase; Provisional.	0
NZ_AP019739.1\|WP_019130785.1\|3079827_3081099_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.72391e-34
NZ_AP019739.1\|WP_019130786.1\|3079261_3079702_-\|PepSY-like-domain-containing-protein	gnl\|CDD\|371505	pfam11396, PepSY_like, Putative beta-lactamase-inhibitor-like, PepSY-like. This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.	1.07683e-29
NZ_AP019739.1\|WP_141419483.1\|3069822_3070896_+\|porin	gnl\|CDD\|369347	pfam07396, Porin_O_P, Phosphate-selective porin O and P. This family represents a conserved region approximately 400 residues long within the bacterial phosphate-selective porins O and P. These are anion-specific porins, the binding site of which has a higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates, while porin P has a higher affinity for orthophosphate. In P. aeruginosa, porin O was found to be expressed only under phosphate-starvation conditions during the stationary growth phase.	3.01983e-16
NZ_AP019739.1\|WP_141419481.1\|3068301_3069027_+\|DNA-repair-protein-RecO	gnl\|CDD\|234622	PRK00085, recO, DNA repair protein RecO; Reviewed.	8.24947e-14
NZ_AP019739.1\|WP_141419487.1\|3078212_3079103_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	4.13913e-16
NZ_AP019739.1\|WP_141419485.1\|3071873_3073244_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	2.95038e-132
NZ_AP019739.1\|WP_019130789.1\|3074754_3076053_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.11058e-56
NZ_AP019739.1\|WP_019130798.1\|3066363_3067260_-\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|274043	TIGR02225, Tyrosine_recombinase_XerD, tyrosine recombinase XerD. The phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerD, one of two closely related chromosomal proteins along with XerC (TIGR02224). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and with homologs of XerD on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerD, as some apparent XerD examples score below the trusted and noise cutoff scores. XerC and XerD interact with cell division protein FtsK. [DNA metabolism, DNA replication, recombination, and repair].	2.0093e-127
NZ_AP019739.1\|WP_019130784.1\|3081147_3081834_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.81815e-68
NZ_AP019739.1\|WP_141419480.1\|3067371_3068199_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|234786	PRK00517, prmA, 50S ribosomal protein L11 methyltransferase.	4.44937e-72
NZ_AP019739.1\|WP_141419489.1\|3083797_3084634_+\|YchF/TatD-family-DNA-exonuclease	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	5.05008e-92
NZ_AP019739.1\|WP_141412436.1\|3084947_3085988_+\|type-I-asparaginase	gnl\|CDD\|199207	cd08963, L-asparaginase_I, Type I (cytosolic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type I L-asparaginases, which are highly specific for asparagine and localized in the cytosol. Type I L-asparaginase acts as a dimer. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase. One example of an enzyme with no L-glutaminase activity is the type I L-asparaginase from Wolinella succinogenes.	3.6211e-120
NZ_AP019739.1\|WP_141412437.1\|3086282_3087095_+\|MotA/TolQ/ExbB-proton-channel-family-protein	gnl\|CDD\|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	7.25903e-30
NZ_AP019739.1\|WP_141419488.1\|3082613_3083711_+\|DNA-processing-protein-DprA	gnl\|CDD\|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	1.83491e-75
NZ_AP019739.1\|WP_141412409.1\|3073370_3074732_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|378963	pfam12831, FAD_oxidored, FAD dependent oxidoreductase. This family of proteins contains FAD dependent oxidoreductases and related proteins.	3.52414e-132
NZ_AP019739.1\|WP_141419484.1\|3070964_3071870_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197317	cd09083, EEP-1, Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.	1.69148e-78
NZ_AP019739.1\|WP_141419490.1\|3084630_3084933_+\|TIGR04076-family-protein	gnl\|CDD\|274964	TIGR04076, conserved_hypothetical_protein, TIGR04076 family protein. Members of this protein family are uncharacterized. The only invariant residue, and one of three other residues better than 90 percent conserved are both Cys. Phylogenetic profiling results and occasional fusion genes suggest a role for members of this family in redox reactions or iron cluster metabolism. Species occasionally have two or three copies.	5.14124e-30

>NZ_AP019739.1|WP_141419486.1|3076068_3077742_-|ribulokinase
MEHAYVIGLDYGTDSVRALLVDALTGREIDSEVALYPRWNKGLYSDPRVARFRQHPKDYLEALRQAVRAVTGRHADLAPYVRALSVDTTASTPCLTDRAGVPLSLHEEYAENPDAMFVLWKDHTGQAECEEINALCARSEINYACHSGNYYSAECFWSKVLHLLRRDEALRRDAWSVVELCDWIPAVLTGCPDAASVKMGHCVCGSKLMWAEEWGGYPPEKFFAELDPVLLPVLHHLPNVNYGCDVAAGTLTGEWASELGLPAGIPVGVGCIDSHSGAVGAGIRYGTVVLNLGTSACYMAVMPPEAMGDKIVEGIFGQVDGSILPRMIGFESGLSAFGDVYAWFKRLLCWPLREILARTELVDAPTRDRLIAETEAGIMDALTQGAAALPLRADAPLATDWLNGRRSPFADSSLTGTLTGLNLSTSAPEIYYAFAEATAFATKHILDHMRDNGVRIDRLIGVGGIAQKSPFVMQLLADTTGMRIDVSDCKQAGAMGAVVHAATIAGLYPSVTEAQQALCAPASRSYVPDVSRQAVLNERYARYRAVGAFTERLKNNR
>NZ_AP019739.1|WP_019130789.1|3074754_3076053_-|MFS-transporter
MNLLKDPNKRKWVIVATMFIAIICNYLDRQLLSILKPEILEHFGIGDMQYAWIVNVFLICYALMYPVSGILVDRFGPKRVMLAGIAVWSLACIGGGLAQTVWQFAVCRGILGLAEPTIFAGQLVAVTLWFEKRQRATANSLCTVGGSLGAVIAPLVIAWLMRWFSNWQEVFLVAGVAGLVIAGLWMVVYRTPSQEILDRTVNVDRMTSSGEEQKSFTLGGLFRTRTLWGAFLIRLISDPVWYFCCFWLPGYLRGMGEAQNLTHEQTLNMIQWIGGIPFLVGALGGILTSVWSDSMIKRGRSALSARKVMLMAVVVVAPLCAAVPYVGASETLSFAWRVGLVVAIFSLVAVMCLSWLYTLPVVLAETFPIKNVASVMGICCGAGALGSVVFNQFVGSIPSEAWYTLFAIMGTLHIIAAVVLWKMVRPESPETK
>NZ_AP019739.1|WP_141412409.1|3073370_3074732_-|FAD-dependent-oxidoreductase
MKTIKEPARDIPVRAEADVLVVGGGPAGIMAAEAAAGDGLRVMLVESRGFLGGNLTIGLPILGFLGRKGNQIIEGSAQRFIDRLRARGAASEHRPCKNHMSLTIIDEEEVKRTALEIMEEKGVEVLLYTFFADAIREGDAVKGVVVESKAGREAILAKTVIDCTGDGDVAFRAGVECRKGDAEGGMQPPTLMFCMKGVDVQRLRDAIVGHPDVYDMDVMPPEQFRTGKFITVGLRTQIRQAQAAGYRIPVARTILITGLADDEIWVNMTRVSGVDSTRPESYTYGEIEGRKQIYEIARYLREFVPGFADARIEKVAPFMGIRESRVIVGRYVLTAEDIIACRRFGDAIAVAGYPVDIHHAKGGDCTMHFCDDSYDIPYRCLLPERVAGLLVAGRCSSMNHEAMASTRVMSTCMALGEAAGRAARLALKAGVQPADLDVEALRAELRATGAYLG
>NZ_AP019739.1|WP_141419485.1|3071873_3073244_-|FAD-dependent-oxidoreductase
MKQIEEPARRIPVRAEVDVLVVGAGPAGLMAAQAAALEKGTKVMLVESRGFLGGNMTIGLPLLGFLGRKGNVVIKGLPLQFVERLQEKGLATHHRACPLHVSLTMIDPEGTKHLAFQIIKECGIDLLMYAFATDVIMEGNTVKGVIIDSKKGREAILAKRVIDCTGDGDIAYRAGAPMNYGNEKGIPQPPTLMFSMRGVDSRKLRDAVADHPDVYDIDFIPNEFFRADDNCTFVGFRNQIKKAREAGYKLPVERTIFMTGMAPDEWWVNMSRVNGIDATDPAQYTQGEIICAEQNEEIVRYLKAYIPGFENAYVDRVAPFMGIRETRRIVGEYILTEDDIFNCARFDDVIAVASYPVDLHHPVGGDCSLYWCPDCYDIPYRCLIPQKIDGLIVAGRNVSMTHLALASARVMAPAMALGEAAGKAAALSVKENVELRDLDVRKLQESLKAEGVYFRE
>NZ_AP019739.1|WP_141419484.1|3070964_3071870_-|endonuclease/exonuclease/phosphatase-family-protein
MFRRILIITGVLLSLAGTAEAGEKAESDDDIHRVMTCNIRITGLEADASYSERVWENRRDLCVETILSRRPDIICLQEVIYDSYAYLKEKLRGYVPYGFAGPEMDPYTEGYHFIGKNVIFFRRDRYEFVSAGCYWLSETPLIGGSCSWNTTRARHCNWVRLRDKRSGRELRVLDVHLDHKSDEARREQIRMVMDECAQYAPDFPQILCGDFNAGIDSAPIGYIRTVDGWREMYESVHGPGETGFTAHAFKGEEYKPEKSHRIDFIFYRGDVEVCDAEIVRDRKGAMYPSDHYFLFSEFTLR
>NZ_AP019739.1|WP_141419483.1|3069822_3070896_+|porin
MKRLLLALAVTAGLFPTTRGAAQQRDSLAATVERLSAEIETLKGRSAAADRILSRLPRISGYLQLGYEWSDDASTFFVKRARVNFQGDISPKIDYRLQLEFASPKIVDIYLRYKPLEALNVQVGQFKVPFSIENTHYVPLKYEFIEYSMAVCRLMGFTDVCGVNATGRDLGAQLYGGLIGRDGYSILNYNVGVFNGEGINIKDKNKSKDVVVRLMVQPLRALSFAGYYYWGEVGADYARRTRYGGGVCYDDGRWIARGEYIAGRTGIVSPDVAEPFDSRGYYAMAACWVTPKWLPAVRFEQFDEVAGRSASRQTNYTAGVTWQPFKHLRCQLNYTYEQYGGTNPDRNVVKAMLTGIF
>NZ_AP019739.1|WP_141419482.1|3069210_3069687_+|hypothetical-protein
MKTNLFLSILFLLAAGVAGAQEPPVTEAEIERQEQQRARETTEQRVEQAVEGELQELLERIPDSLRVDKWIPGTVVVDGHILEPVPLHKPEMERWSMPRQQQVTPIERDFVRRLTSGWLAVSNGQAFNWEYGRRIWGVGSIYPGSYLDARTLSFPLPR
>NZ_AP019739.1|WP_141419481.1|3068301_3069027_+|DNA-repair-protein-RecO
MKSYKARGIVLHTLKYGDSGMVVYLLTDSGGRQSYMVQGVRSARGHGSKLALFQPMFAVEFEGLESSRMQMHRFREVRSGIVLQSLPFDVRKSTIALFMAEVLYRLVKECEPNQRLFDFVWGSVAALDALDEGVANFHLWFLTNLSRFLGFSPGNAYLPGAWFDIREGSFTPLRPSHGEMLSTDDARILHDLLECDVRYIAEIGLNRRQRVAYLDALLVYYGYHLDAIHAVQSVRILQEVF
>NZ_AP019739.1|WP_141419480.1|3067371_3068199_+|50S-ribosomal-protein-L11-methyltransferase
MDYIELTLDAADAEQAEILTAELADFPFESFEQEGARLKAYIPQERLADCKGEVDALLARYGVGRATFLSIEPQNWNALWESNFTPVEVDGRLTIRAPFHAPAATEAEVVIMPKMSFGTGHHATTCLMASGLLDRDVTGLRGLDMGSGTGVLAIVAALRGAETVDAVDIDEWAYENCVENIRANGVETRVTPLLGDIGAIAGRRYDFIAANINRNILLAQLPAYAAALDAGGWLLMSGILEADVAPLSEAARAAGFSVTGHALRDGWARVDAVKN
>NZ_AP019739.1|WP_019130798.1|3066363_3067260_-|site-specific-tyrosine-recombinase-XerD
MAENSRRWAEISRRYRTYIKLEKRLSANTVESYMRDLEQFAHFVLRMWDVPPRKVESQMIERYMAWLYDRGCEKSSQARALSGLKSFFNYLLLTDAIESSPLEFIEMPKFSRRLPDVLSTAEIDRILAAIDRTTPKGVRDDAMLELLYSCGLRVSELISLRLCDLFFGEGYIRVIGKGDKQRLVPVSDTAREKIYAYLDCRKGGSSSEETLFLNNRGGRLSRVMIFTIIKQAVLRAGIDKQVSPHTFRHSFATHLLEGGASIRQVQEMLGHENIITTEIYTHLDNEHLRETVERHLPI
>NZ_AP019739.1|WP_141419487.1|3078212_3079103_+|EamA-family-transporter
MNNPKGIAYAALSSSTFGLAPLFTVTLLRDGFSPFEVLTYRWGVASAALLLFGLATGRRLRIARRDFGVVFLLSLFRAGCSLSLVFAYANIATGVASTIHFLYPLAVALAMTLFFRERCSRRLFTAIAVSLAGAALLSSGDIRSNGGDATFGIAAAFFSVISYAGYIIGVRKSRAAQVESTTLTLLVMAIGAALFAATGSLTSGLHWVDDSRTWGNILGLAIPATAVSNIALVKAIKAIGPTLTSILGAMEPLTAVLIGVLHFGEPFTAAGIAGVVLSVAAVTIVVTQGGKPAGNA
>NZ_AP019739.1|WP_019130786.1|3079261_3079702_-|PepSY-like-domain-containing-protein
MKKLLILAAAVFALGTSTVSADNDRPISVSELPEKAQQFIRQHFPNEKVSFAKMERELFDTTYEVIFTSSSKVEFLKNGDWKEVDCKYSTVPAAIIPQQIAQYVSQYYPDTSVVQIDRDKRDYEVKLTNGLELTFDLKFNLIDIDD
>NZ_AP019739.1|WP_019130785.1|3079827_3081099_-|HAMP-domain-containing-histidine-kinase
MKLISRIALRLSLALLPLMALWGVLFYFTMVDEINDEADDALEDYSELIVKRMLAGRELPKPNNGSNNSYSIVPIGAPEAAVRPHIDYYDAEVYIPEKEETEPARVLTTIFQDADGAYYELKVATPTFEKDDLLRAILYWVVFLYLLLLLTTISLTVWVFHRSMRPLYELLRWLDDYTPGRRGAPVPCSTRIVEFRRLSAAAQQAVDRSEALFEQQKHFIGNASHELQTPLAVLGNRIEWLLDNTEPTEKQMEELLKMQRTLRQIVRLNKTLLLLTKIDNGQFPESSEVDLAAVVGEQVALYDEIYAGRGIACTVSAPEAFVVRMNESLASTLVTNLLKNAYLHTAEGGAVGVELRDRTLTVTNDGTAPLDAEHIFERFYQGARKEGSTGLGLALVSAVGRYYGLRIDYRFEGGRHRFSVRWP
>NZ_AP019739.1|WP_019130784.1|3081147_3081834_-|response-regulator-transcription-factor
MKILIVEDEPSLREIMYRALVQEHYVVETAATYADADAKVAGYSYDCILLDIMLPDGNGLRLLEHIKELRKRENVIIISARNSLEDKVLGLEQGADDYLPKPFHTAELLARIRSVLRRGRSGGDLSLSLGNVSLWPEGRRVEVEGRELALLKKEFDILLYFMQRPNHLVDKAVLAEAVWGDHADDADNFHFVYAQMKNLRRKLAEAGATVELKSVYGFGYKLSLPQSE
>NZ_AP019739.1|WP_141419488.1|3082613_3083711_+|DNA-processing-protein-DprA
MAIDDIALTLVPGLGVKGVVHLLEVFGTAQAIFAASADELAGRAELRPDVARSIAARKSHPEAERELRHCRRHGITPLASTDDAYPALLREIPDYPHVLYIKGNAEVLSQRCLSMVGTRRISTYGQRLCDELVRGLTRIPQVVVVSGLAFGVDVACHRAALAAGIPTVGVLANPLPNVTPAQHTSVALDMIERGGALISELHSQSKQRGTFYLARNRIIAGLSAGTVVIESPASGGSLATAHYADGYDRTVMAPPGRTTDANSFGTNSLIRNRKALLIRSADDIAEELQWEFALSRDEKTAPAPTPELTAEEREVLSLLGDEPRTLAELIAASGRDYAALSVLLMGLELSQAVRQLPGNRYERFR
>NZ_AP019739.1|WP_141419489.1|3083797_3084634_+|YchF/TatD-family-DNA-exonuclease
MKLIDTHSHLYEPEFDDDREAAVARAREAGVAALLLPAIDTASDRRLFDLCRSHPEYCFPMIGLHPTSVNDNPAWREELARVDRYLLDPPAGIRFCAIGEIGLDYYWSDAFVAQQTEAFVAQLRLAARFDLPVAIHTRAAWDDMCRIIEAETERARADGRRLRGVFHAFSEGAAAFERLCGCGDFRFGIGGTVTFKKSGVAEIVRTMPLDRIVLETDCPYLTPAPYRGQRNESAYVRLVCDKIAELKGLAAETVAAATTANAEALFGIRYTEKNTERR
>NZ_AP019739.1|WP_141419490.1|3084630_3084933_+|TIGR04076-family-protein
MKKIKITVVRKVCHRDLIERYENPIDHACDMREGQVFVADGWQRPDGLCESAWQTLSPFVMTLAHGGTDLYDGWMKNPASAMISCNDGFRPVSFLIETLD
>NZ_AP019739.1|WP_141412436.1|3084947_3085988_+|type-I-asparaginase
MLSSILIIYTGGTIGMKTDPATGVLVPFDFRGIYDEFPAIRSLQVRIDVQSLTPVIDSSNVTPALWLHLAELIRDNYARYDGFVVLHGTDTMSYTASALSFLLENLAKPVVFTGSQIPIGVLRTDGRENLITAIEIAAAHDAEGPLVPEVSLYFQNRLFRANRTVKQSAEEFAAFRSYNYPALAEVGVNITFHRDYIHRPAHADAELRVAAALDDRVLVIRLFPGLREQVLRAMLSIEGLRAVVLETYGAGNAPTAPEFIRAVREAVARGLLVMNVTQCSGGRVAMELYETGRQLQEAGVICGHDITTEAAVAKLMYVLGQNLPAERTQRLLRHALRGEFTDAGIA
>NZ_AP019739.1|WP_141412437.1|3086282_3087095_+|MotA/TolQ/ExbB-proton-channel-family-protein
MKKLFLILSVAMFSLGTVDAFAQDNANEGAATEQAAATEQAAVAETTTVADVDAEATIAGESMHHVMMQKFLEGGWAWMLPILIFLIIGLAVAIERILYLSLSTINSKKFIAQIEEALKNGGIDAAMEVARNTRGPIASIYYQGLLRYNQGLDAVEKSIVSYGSVQTGQMESGLTWIGLFIALSPMLGFMGTVVGMIDAFDAIQAAGDISPTLVAGGIKVALLTTLMGLIAAVILQLFYNYIVSKIDSLVNEMEDTSITLTDILTAYNKK
>NZ_AP019739.1|WP_019130770.1|3087124_3087544_+|hypothetical-protein
MKKILNIILGVLLAVMAVLGIYAIATGGSEASISLNLIWCYVLLALAIASAIFCAIFGMIQNPAGVKGTLLSFALIVVVVLVSYFIAASHDTVIPDFASGGVFPRTPTVIADCGIIVTYVAMIAAVVVALYSEVAKLFK

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Crispr_ID: NZ_AP019739_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_AP019739_23

3299370-3299468

Orphan

Consensus_repeat	Method
ATTGCCGAGTCGGAGTATCTTCGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_AP019739_23

>merge|NZ_AP019739|23|3299370-3299468|CRISPRCasFinder
ATTGCCGAGTCGGAGTATCTTCGGCGTCGGCCAAAGTACGATTAAGCGAGGGCAATGTCAAATTTATTTGAACATTGTCGAGTCGGAGTATCTTCGGCG

>NZ_AP019739|23|22|3299370-3299468|CRISPRCasFinder
ATTGCCGAGTCGGAGTATCTTCGGCG	TCGGCCAAAGTACGATTAAGCGAGGGCAATGTCAAATTTATTTGAAC
ATTGTCGAGTCGGAGTATCTTCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019739.1\|WP_019130597.1\|3292107_3292833_+\|DUF3298-domain-containing-protein	unknown	unknown	gnl\|CDD\|378702
NZ_AP019739.1\|WP_141419579.1\|3290364_3291663_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|227333
NZ_AP019739.1\|WP_141419582.1\|3295440_3296283_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215633
NZ_AP019739.1\|WP_019130588.1\|3300534_3300927_-\|heat-shock-protein-Hsp15	unknown	unknown	gnl\|CDD\|224109
NZ_AP019739.1\|WP_141419581.1\|3294282_3295047_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_AP019739.1\|WP_141419580.1\|3292836_3294090_+\|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl\|CDD\|272979
NZ_AP019739.1\|WP_019130590.1\|3298723_3299320_-\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472
NZ_AP019739.1\|WP_141419584.1\|3297160_3298558_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380191
NZ_AP019739.1\|WP_141419578.1\|3289012_3290368_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_AP019739.1\|WP_019130595.1\|3294094_3294286_+\|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl\|CDD\|376855
NZ_AP019739.1\|WP_019130589.1\|3299940_3300531_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|372434
NZ_AP019739.1\|WP_141419583.1\|3296299_3297145_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_AP019739.1\|WP_141419584.1\|3297160_3298558_+\|hypothetical-protein	gnl\|CDD\|380191	NF033187, internalin_J, class 1 internalin InlJ. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin J (InlJ).	7.00349e-25
NZ_AP019739.1\|WP_019130597.1\|3292107_3292833_+\|DUF3298-domain-containing-protein	gnl\|CDD\|378702	pfam11738, DUF3298, Protein of unknown function (DUF3298). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	1.32475e-15
NZ_AP019739.1\|WP_141419578.1\|3289012_3290368_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	4.2358e-170
NZ_AP019739.1\|WP_141419579.1\|3290364_3291663_+\|PAS-domain-containing-protein	gnl\|CDD\|227333	COG5000, NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms].	2.08262e-42
NZ_AP019739.1\|WP_141419582.1\|3295440_3296283_+\|hypothetical-protein	gnl\|CDD\|215633	PLN03210, PLN03210, Resistant to P. syringae 6; Provisional.	0.00335623
NZ_AP019739.1\|WP_019130588.1\|3300534_3300927_-\|heat-shock-protein-Hsp15	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	7.94171e-18
NZ_AP019739.1\|WP_019130589.1\|3299940_3300531_-\|HD-domain-containing-protein	gnl\|CDD\|372434	pfam13023, HD_3, HD domain. HD domains are metal dependent phosphohydrolases.	1.51258e-49
NZ_AP019739.1\|WP_141419581.1\|3294282_3295047_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	2.84969e-13
NZ_AP019739.1\|WP_141419580.1\|3292836_3294090_+\|exodeoxyribonuclease-VII-large-subunit	gnl\|CDD\|272979	TIGR00237, exodeoxyribonuclease_VII_large_subunit, exodeoxyribonuclease VII, large subunit. This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA].	8.25427e-114
NZ_AP019739.1\|WP_019130590.1\|3298723_3299320_-\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	9.91376e-109
NZ_AP019739.1\|WP_019130595.1\|3294094_3294286_+\|exodeoxyribonuclease-VII-small-subunit	gnl\|CDD\|376855	pfam02609, Exonuc_VII_S, Exonuclease VII small subunit. This family consist of exonuclease VII, small subunit EC:3.1.11.6 This enzyme catalyzes exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones.	5.0171e-07

>NZ_AP019739.1|WP_019130590.1|3298723_3299320_-|GTP-cyclohydrolase-I-FolE
MEKKLYEKQEIYDPATIAELSEHYAAILRLLGEDPTREGLLKTPERVAKAMAFMTKGYAEDPRDILLSAMFREEYRQMVLVRDIEVYSLCEHHMLPFYGKAHVAYIPDGYITGLSKVARVVECFARRLQVQERLTVQIRDCIHEALHPLGVAVVIEASHMCMQMRGVEKQESSTTTSAFTGIFLRDHRTREEFMELIR
>NZ_AP019739.1|WP_141419584.1|3297160_3298558_+|hypothetical-protein
MKRTLFLFCLLWSLSLCLSACSDDDGLVYPPNVAGAIPDGEFRVLCLQLADTDLNGVISKEEALAVRKIDCTPDPSYVKAISSLEGLHYFANLETLYCGGQLLTSIDLSGNPRLRHLDCSFDSLEELDVSSCSELETLSCSGCGLERLLLPRTATLTALDCSDNLLTTLDVTDYPALLVLYCNSNVFMTLDVRSNPELMALRCSDIDGLDVSANLKLEYLDCWNVSCERLDLSRHEALYRLLLRESRISDIDFGGTSALDYFSLVQADCTRLDLSGCSKLDYVTIADVPLTKLDLPASVGSVTLNRVDLERLEVKGTVDETGFATIFHIENCERLKRLDFSSILRTIRCKNCPALTEMNLGDCRGLSSFTCTGTALSSLDLSQRGDFRFGTVDCSDNRLTTLILPPEVYTLSCQGNLLEELDISGSYIHSIEYRPMETLRRIRLRRDQDNYRLGDTTGIELVYVD
>NZ_AP019739.1|WP_141419583.1|3296299_3297145_+|hypothetical-protein
MKKRSILLSGLFVLMMCLAGCSDDDEQPDPQLPPLVWPDDVAAAIPDEGFREYCLERHDKDKDGRLSKDEVLAVTSMINYDARNIRSFEGIEYFGNLEKLYWGYCDVPNLDLRYNTRLKRVRLEGSSNLVVFRGPVGYTPLTIEFLNPCRKLQTFDLSGCANVRELLISARVPADAISATIDLPDPSHLQYLTIAAVDAGCYDALLAGAVNLKRLYCDFYPDAVLDLSHCPKLEVLSVQTFAGSSLSKIRLRKEAPLDMQFKIRNEDGEDCRHLIEIEYVQ
>NZ_AP019739.1|WP_141419582.1|3295440_3296283_+|hypothetical-protein
MKPYFSWKTLCLLLCLALLAGCSDDEQPDPQLPPLVWPDDVATAIPDEGFREYCLERYDRDKDGRLSKDEVLAVTSMTNYATRYIRSLEGIEYFGNLETLYWGECDVPSLDLRYNARLEKVRFSYPTKMTCLRGPIGNAPLAIEFLFSCNLEELDLSGCENVQELLTSAAVLEEVTLTSVDLPDPSHLQYLNIAAANAGCYDTLLAGAVNLKELYCNFYPDAVLDLSGCPKLESLTVLTFAESALAKIRLRKGLSQLRELKIYDENNKDYSHLVEIEYVE
>NZ_AP019739.1|WP_141419581.1|3294282_3295047_+|methyltransferase-domain-containing-protein
MKRLIRWALNHVPRPLLQRLAGWAVPVAGLFYVGRGRECPVCGARRRRFLPYGYVAPRADALCPSCLSLERHRLLWLYLTRETDLLRRPQRILHIAPEVCLMKRLRHRAADYTTADLESPLAELHFDVLRIPLPDASYDVLICNHLLEHVADDRRALGEFYRILRPGGWGILLSPVDRSRAATFEDDSITDPEERTRIFGQYDHRRIYGRDYGGRLREAGFEVREIDYAARFSAEERRRYALPDDWIYVVRRPL
>NZ_AP019739.1|WP_019130595.1|3294094_3294286_+|exodeoxyribonuclease-VII-small-subunit
MDKKELTYDEAMAEIEAILAKFRNEEMSVDALAAEVRRATTLIAFCRKRLLKAESDVKKITGE
>NZ_AP019739.1|WP_141419580.1|3292836_3294090_+|exodeoxyribonuclease-VII-large-subunit
MIAAQYITLSELQRRVRQVLEERFALPLWVSAEIAEVKVNYSGHCYLELVEKGEGDGVPKAQARAVIWRSQYARIAAYFEAETGQRLAAGMRILAKATVNYHELYGFSLQLLDVDPAYTLGDMERQRQQTIARLQAEGVWEMNRQQAMPAVVQRIAVVSSSRAAGYQDFCNELAKSPYRFCLTLFDAVVQGAAAEDSIVDALSRIAAAGEAFDAVVMIRGGGSSSDLNCFNAYRLCNHVAQFPLPVVTGIGHDKDTSVADLVAHTALKTPTAVAAWLVERMAQADGYLAWAGLQLGNAALAITHSAAVGLERLGAALAQQSQRLLQEGRSRLDRAEETLLAAPADLLRGHDRRLAAASELLLSYSVERVLRRGFAVVRRGGEALRSAEGLSPGDRLDITLADGEVQAAVVACTKKKR
>NZ_AP019739.1|WP_019130597.1|3292107_3292833_+|DUF3298-domain-containing-protein
MKLPALVLLAAFAAGMAGCCRRAAAPQFAERSLDTVVRCGAVPCDLSYRFLTIANADRSEALAAIENANVNYFFALEDFTGTAEEAARRFIERFAADNACDTLYMPDMRYSLSVAAAQAPVDTLTVYTIRRESYTGGAHGMRTTEYHNYWTKGGYELSLGDLFPEEQLPRLTERIKAKLREQYGAADDEELAQRGFFPETIAPTENFEVTPEGIVFHYNPYDIACYAIGEVDVPFTKEELK
>NZ_AP019739.1|WP_141419579.1|3290364_3291663_+|PAS-domain-containing-protein
MKYGGDLFRLVSHVVVLIAVTAAAAALSATGRYAFALLLLPFGGIAVYRLVRLYDASMRRVTFLLDAVENNDLNFRFCEGAASGGERALNVALNRIREIIVRAKLRAEERERYYRLIMECARTGLLTVDDRGSVYQVNDEALRIFGLPRMTHVRQVEPLLPEACRALTAIRSGERLRVRSRNESGEVNLSLTCSEITLDRRHLRVVAVSDIDDYLSAVQVESWSKLTRILTHEIMNSLAPITSLSDTLLHLGRRLDADVERGLDTISSTSRRLTAFVETFRRFTRIPEPRKSAFEVRGMLERAVMLAGVSDVVRLDVEPSQMLIYADEGLVEQVAVNLLKNAREAAEGLSDGRIEVVARISADETVRIDFGDNGAAIPAEVSDNIFTPFFTTKPDGSGIGLSVSRRIMQLHGGSLRLTSNVDGKVTFTLFFA
>NZ_AP019739.1|WP_141419578.1|3289012_3290368_+|sigma-54-interacting-transcriptional-regulator
MAKEGNLLIVDDNSSILGALRLLLERHFAKVTTLTSPKLLDTVLRGEAVDAVLLDMNFTAGVNNGNEGIYWLRRIRDIRPDVKVVLFTAYADVDLAVRSMRDGAVDFVVKPWDNERLVASLRNACELARSQREVKRLREIRRELTVDEPMFWGTSPAMERIREIVEKVAATDANILITGENGTGKEMLAREIHRRSHRSGGPMVAVDMGAVPETLFESELFGHVKGAFTDARTDRAGKFEVADGGTLFLDEIGNLPLHLQPKLLTALQSGAIVRVGSNLPVKVDCRLISATNRDLFGMTAGGSFREDLLYRINTIHIDLPPLRQRREDILLLARTFLVRYAGKYRKPIRDFDAAAQHELVAHAWAGNIRELQHTVEKAVILCDGTEISPATLLLRPVATGPSPAAFTTFEEMERAMIEQAMERHGGNLSAVAQQLGVTRQTLYNKIKRYGL
>NZ_AP019739.1|WP_019130589.1|3299940_3300531_-|HD-domain-containing-protein
MRPERLFEILAVAERLKCNTRHSWTSTGRRESVAEHSWRLALMALLVADEFPDVDCGRVVRMCLVHDLGEAFTGDIPAFEKRRQDETHEAALLARWVETLPEPLRAEWRSLYAEMEALATPEARLYKALDKLEAVIQHNEADIATWLPLEYDLNIAYGADEVAWNGYLRRLKEAANEISRQKIAAAKEQVPDDAGK
>NZ_AP019739.1|WP_019130588.1|3300534_3300927_-|heat-shock-protein-Hsp15
MDDVRLDKYLWAVRIFKTRSDAAEAIRTNRVTVGGATCKPSREVRIGDVIAVKRMPVVYQYKVLDLVTSRQPAKNVPAYCLNITPQEELDKLDAPRETIFVFRDRGTGRPTKKERRELDSLMDNMLYEEE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP019739_18	18.1\|2602867\|30\|NZ_AP019739\|CRISPRCasFinder	2602867-2602896	30	NZ_AP019739.1	2449750-2449779	0	1.0
NZ_AP019739_1	1.2\|43401\|50\|NZ_AP019739\|PILER-CR	43401-43450	50	NZ_AP019739.1	43527-43576	1	0.98
NZ_AP019739_9	9.1\|1244359\|32\|NZ_AP019739\|CRISPRCasFinder	1244359-1244390	32	NZ_AP019739.1	1713343-1713374	1	0.969
NZ_AP019739_9	9.1\|1244359\|32\|NZ_AP019739\|CRISPRCasFinder	1244359-1244390	32	NZ_AP019739.1	1978870-1978901	1	0.969
NZ_AP019739_9	9.1\|1244359\|32\|NZ_AP019739\|CRISPRCasFinder	1244359-1244390	32	NZ_AP019739.1	1504544-1504575	2	0.938
NZ_AP019739_9	9.1\|1244359\|32\|NZ_AP019739\|CRISPRCasFinder	1244359-1244390	32	NZ_AP019739.1	1799519-1799550	2	0.938
NZ_AP019739_14	14.1\|1952058\|50\|NZ_AP019739\|CRISPRCasFinder	1952058-1952107	50	NZ_AP019739.1	1056270-1056319	2	0.96
NZ_AP019739_14	14.1\|1952058\|50\|NZ_AP019739\|CRISPRCasFinder	1952058-1952107	50	NZ_AP019739.1	1295592-1295641	2	0.96
NZ_AP019739_14	14.1\|1952058\|50\|NZ_AP019739\|CRISPRCasFinder	1952058-1952107	50	NZ_AP019739.1	1295666-1295715	2	0.96
NZ_AP019739_18	18.1\|2602867\|30\|NZ_AP019739\|CRISPRCasFinder	2602867-2602896	30	NZ_AP019739.1	1213742-1213771	2	0.933
NZ_AP019739_18	18.1\|2602867\|30\|NZ_AP019739\|CRISPRCasFinder	2602867-2602896	30	NZ_AP019739.1	2604812-2604841	2	0.933
NZ_AP019739_21	21.1\|3069107\|35\|NZ_AP019739\|CRISPRCasFinder	3069107-3069141	35	NZ_AP019739.1	674223-674257	2	0.943

1. spacer 18.1|2602867|30|NZ_AP019739|CRISPRCasFinder matches to position: 2449750-2449779, mismatch: 0, identity: 1.0

ctctcttcgttttctcgcctcggcatagcc	CRISPR spacer
ctctcttcgttttctcgcctcggcatagcc	Protospacer
******************************

2. spacer 1.2|43401|50|NZ_AP019739|PILER-CR matches to position: 43527-43576, mismatch: 1, identity: 0.98

acttcgtcgtagatacttcgtctcggcataatcaagctggcgcttgcttc	CRISPR spacer
acttcatcgtagatacttcgtctcggcataatcaagctggcgcttgcttc	Protospacer
*****.********************************************

3. spacer 9.1|1244359|32|NZ_AP019739|CRISPRCasFinder matches to position: 1713343-1713374, mismatch: 1, identity: 0.969

ctatctaagcggaggcttgtcctccgcaaagt	CRISPR spacer
ctatctaagcggaggctcgtcctccgcaaagt	Protospacer
*****************.**************

4. spacer 9.1|1244359|32|NZ_AP019739|CRISPRCasFinder matches to position: 1978870-1978901, mismatch: 1, identity: 0.969

ctatctaagcggaggcttgtcctccgcaaagt	CRISPR spacer
ctgtctaagcggaggcttgtcctccgcaaagt	Protospacer
**.*****************************

5. spacer 9.1|1244359|32|NZ_AP019739|CRISPRCasFinder matches to position: 1504544-1504575, mismatch: 2, identity: 0.938

ctatctaagcggaggcttgtcctccgcaaagt	CRISPR spacer
ctatctgagcggaggctcgtcctccgcaaagt	Protospacer
******.**********.**************

6. spacer 9.1|1244359|32|NZ_AP019739|CRISPRCasFinder matches to position: 1799519-1799550, mismatch: 2, identity: 0.938

ctatctaagcggaggcttgtcctccgcaaagt	CRISPR spacer
ctgtctaagcggaggcttgccctccgcaaagt	Protospacer
**.****************.************

7. spacer 14.1|1952058|50|NZ_AP019739|CRISPRCasFinder matches to position: 1056270-1056319, mismatch: 2, identity: 0.96

gaagcaagcgtcagcttgattgtgccgagacggagtatctaagacgaagt	CRISPR spacer
gaaacaagcgtcagcttgattatgccgagacggagtatctaagacgaagt	Protospacer
***.*****************.****************************

8. spacer 14.1|1952058|50|NZ_AP019739|CRISPRCasFinder matches to position: 1295592-1295641, mismatch: 2, identity: 0.96

gaagcaagcgtcagcttgattgtgccgagacggagtatctaagacgaagt	CRISPR spacer
gaagcaagcgtcagcttgattatgccgagacggagtatctaagacgcagt	Protospacer
*********************.************************ ***

9. spacer 14.1|1952058|50|NZ_AP019739|CRISPRCasFinder matches to position: 1295666-1295715, mismatch: 2, identity: 0.96

gaagcaagcgtcagcttgattgtgccgagacggagtatctaagacgaagt	CRISPR spacer
gaagcaagcgtcagcttgattatgccgagacggagtatctaagacgcagt	Protospacer
*********************.************************ ***

10. spacer 18.1|2602867|30|NZ_AP019739|CRISPRCasFinder matches to position: 1213742-1213771, mismatch: 2, identity: 0.933

ctctcttcgttttctcgcctcggcatagcc	CRISPR spacer
ctctcttcgttttcccgcctcggcaaagcc	Protospacer
**************.********** ****

11. spacer 18.1|2602867|30|NZ_AP019739|CRISPRCasFinder matches to position: 2604812-2604841, mismatch: 2, identity: 0.933

ctctcttcgttttctcgcctcggcatagcc	CRISPR spacer
ctctcttcgttttctcgcttcggcacagcc	Protospacer
******************.******.****

12. spacer 21.1|3069107|35|NZ_AP019739|CRISPRCasFinder matches to position: 674223-674257, mismatch: 2, identity: 0.943

actatgccatggcgagaaaacgaagaatgaaattc	CRISPR spacer
actatgccgaggcgagaaaacgaagaatgaaattc	Protospacer
********. *************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP019739_11	11.1\|1610437\|33\|NZ_AP019739\|CRISPRCasFinder	1610437-1610469	33	NC_019699	Chroococcidiopsis thermalis PCC 7203 plasmid pCHRO.01, complete sequence	279113-279145	7	0.788
NZ_AP019739_11	11.1\|1610437\|33\|NZ_AP019739\|CRISPRCasFinder	1610437-1610469	33	NZ_CP031069	Bacillus sp. JAS24-2 plasmid pl626, complete sequence	261393-261425	7	0.788
NZ_AP019739_11	11.1\|1610437\|33\|NZ_AP019739\|CRISPRCasFinder	1610437-1610469	33	NZ_CP053952	Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence	374265-374297	7	0.788
NZ_AP019739_11	11.1\|1610437\|33\|NZ_AP019739\|CRISPRCasFinder	1610437-1610469	33	NZ_CP053949	Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence	24323-24355	7	0.788
NZ_AP019739_11	11.1\|1610437\|33\|NZ_AP019739\|CRISPRCasFinder	1610437-1610469	33	NZ_CP045607	Bacillus cereus strain SB1 plasmid p1, complete sequence	335861-335893	7	0.788

1. spacer 11.1|1610437|33|NZ_AP019739|CRISPRCasFinder matches to NC_019699 (Chroococcidiopsis thermalis PCC 7203 plasmid pCHRO.01, complete sequence) position: , mismatch: 7, identity: 0.788

aaagcaaataaatttgatattgccttcgcttaa	CRISPR spacer
atcgcaaataaattagctattgccttcgggaaa	Protospacer
*  *********** * ***********   **

2. spacer 11.1|1610437|33|NZ_AP019739|CRISPRCasFinder matches to NZ_CP031069 (Bacillus sp. JAS24-2 plasmid pl626, complete sequence) position: , mismatch: 7, identity: 0.788

aaagcaaataaatttgatattgcct-tcgcttaa	CRISPR spacer
gaagcaaataacattgatattgcctatcaagta-	Protospacer
.**********  ************ **.  **

3. spacer 11.1|1610437|33|NZ_AP019739|CRISPRCasFinder matches to NZ_CP053952 (Bacillus cereus strain FDAARGOS_798 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.788

aaagcaaataaatttgatattgcct-tcgcttaa	CRISPR spacer
gaagcaaataacattgatattgcctatcaagta-	Protospacer
.**********  ************ **.  **

4. spacer 11.1|1610437|33|NZ_AP019739|CRISPRCasFinder matches to NZ_CP053949 (Bacillus cereus strain FDAARGOS_799 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.788

aaagcaaataaatttgatattgcct-tcgcttaa	CRISPR spacer
gaagcaaataacattgatattgcctatcaagta-	Protospacer
.**********  ************ **.  **

5. spacer 11.1|1610437|33|NZ_AP019739|CRISPRCasFinder matches to NZ_CP045607 (Bacillus cereus strain SB1 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.788

aaagcaaataaatttgatattgcct-tcgcttaa	CRISPR spacer
gaagcaaataacattgatattgcctatcaagta-	Protospacer
.**********  ************ **.  **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

292666 : 300318

Synechococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_019130343.1\|292666_293383_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	2.5e-43	42.5
WP_019130342.1\|293458_294871_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.0e-48	32.1
WP_019130341.1\|294921_295947_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.9e-61	40.2
WP_141418192.1\|295954_296518_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.7e-19	37.2
WP_141418193.1\|296528_298058_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	4.7e-76	48.3
WP_141418194.1\|298205_299456_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_026074877.1\|299460_300318_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	2.6e-31	40.9

DBSCAN-SWA_2

1437206 : 1444696

Enterobacteria_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_162851460.1\|1437206_1437674_-	thioredoxin	A0A1J0GW78	Streptomyces_phage	3.6e-11	39.5
WP_141418692.1\|1438425_1439484_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.2e-83	49.4
WP_161602000.1\|1439563_1440334_-	glycerophosphodiester phosphodiesterase	A0A173GBD0	Staphylococcus_phage	1.8e-07	26.2
WP_141418693.1\|1440364_1441231_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	5.3e-40	40.9
WP_141418694.1\|1441223_1441796_-	dTDP-4-dehydrorhamnose 3,5-epimerase	A0A1D8EQH2	Escherichia_phage	1.8e-44	55.8
WP_019129555.1\|1441840_1442722_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	5.3e-104	62.7
WP_141418695.1\|1442746_1444696_-	polysaccharide biosynthesis protein	A0A1V0SAI8	Catovirus	3.7e-25	29.2

DBSCAN-SWA_3

2950301 : 2957307

unidentified_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_141419411.1\|2950301_2951342_+	hypothetical protein	H7BUJ8	unidentified_phage	4.9e-117	57.4
WP_141419412.1\|2951338_2953096_+	PHP domain-containing protein	H7BUJ7	unidentified_phage	4.0e-119	48.3
WP_141419413.1\|2953061_2953829_+	site-specific DNA-methyltransferase	A0A2I7QM56	Vibrio_phage	1.3e-66	51.9
WP_141419414.1\|2953821_2954364_+	HNH endonuclease	E5DV63	Deep-sea_thermophilic_phage	1.8e-30	45.4
WP_141419415.1\|2954360_2956532_+	DNA polymerase III subunit alpha	H7BUJ5	unidentified_phage	1.6e-250	55.9
WP_141419416.1\|2956539_2957307_+	3'-5' exonuclease	H7BUJ3	unidentified_phage	1.1e-68	51.2

Anti-CRISPR protein detection

Acr_ID: NZ_AP019739.1|WP_004291533.1|954096_954513_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: NZ_AP019739.1|WP_004319134.1|1921289_1921745_-|hypothetical-protein

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Acr_ID: NZ_AP019739.1|WP_141419123.1|2391874_2392291_+|PcfK-like-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_AP019739.1|WP_004291533.1|954096_954513_+|hypothetical-protein

954096_954513_+

138 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|40	0.5571428571428572	0.9855072463768116	0.9929078014184397

NZ_AP019739.1|WP_004319134.1|1921289_1921745_-|hypothetical-protein

1921289_1921745_-

151 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|40	0.5819672131147541	0.8145695364238411	0.8652482269503546

NZ_AP019739.1|WP_141419123.1|2391874_2392291_+|PcfK-like-protein

2391874_2392291_+

138 aa aa

hit_Aca_id	identity	query_coverage	hit_coverage
gnl\|BL_ORD_ID\|40	0.5808823529411765	0.9855072463768116	0.9574468085106383

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_AP019739

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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