CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022310	Streptomyces asterosporus strain DSM 41452 chromosome, complete genome	25 crisprs	csa3,DEDDh,DinG,WYL,cas3,Cas9_archaeal,cas4,casR,csb2gr5,cas7,cas8u1	8	10	1	0

1. NZ_CP022310

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022310_1

• CRISPR_ID: NZ_CP022310_1
• CRISPR_location: 918390-918500
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_1

Consensus_repeat	Method
CCACCGGGGACCCGTTGGTACGAGACCACCGGGGTCGGA	CRISPRCasFinder

spacers of NZ_CP022310_1

>1.1|918429|33|NZ_CP022310|CRISPRCasFinder
TGGTGCGGGCCGCCGAGGTTCGGTGGTTCGGGA

CRISPR arrays and Neighbor proteins around NZ_CP022310_1

CRISPR arrays

The CRISPR arrays of NZ_CP022310_1

>merge|NZ_CP022310|1|918390-918500|CRISPRCasFinder
CCACCGGGGACCCGTTGGTACGAGACCACCGGGGTCGGATGGTGCGGGCCGCCGAGGTTCGGTGGTTCGGGACCACCGGGGACCAGTTGGTACGAGACCACCGGGGTCGGA

>NZ_CP022310|1|1|918390-918500|CRISPRCasFinder
CCACCGGGGACCCGTTGGTACGAGACCACCGGGGTCGGA	TGGTGCGGGCCGCCGAGGTTCGGTGGTTCGGGA
CCACCGGGGACCAGTTGGTACGAGACCACCGGGGTCGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142191926.1|923149_924343_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP022310.1|WP_142191986.1|929045_929960_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197666
NZ_CP022310.1|WP_142231220.1|917859_918099_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142231217.1|910814_911816_-|proline-racemase	unknown	unknown	gnl|CDD|368491
NZ_CP022310.1|WP_142191928.1|925140_927249_+|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NZ_CP022310.1|WP_142191929.1|927533_928940_+|carbohydrate-binding-protein	unknown	unknown	gnl|CDD|185691
NZ_CP022310.1|WP_142191927.1|924339_925011_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_CP022310.1|WP_142191925.1|921615_922953_-|6-phospho-beta-glucosidase	unknown	unknown	gnl|CDD|133432
NZ_CP022310.1|WP_142231216.1|910149_910818_-|FCD-domain-containing-protein	unknown	unknown	gnl|CDD|224715
NZ_CP022310.1|WP_142191917.1|914076_914376_-|(2Fe-2S)-binding-protein	unknown	unknown	gnl|CDD|379229
NZ_CP022310.1|WP_142191919.1|915600_916260_-|hypothetical-protein	unknown	unknown	gnl|CDD|375319
NZ_CP022310.1|WP_142191924.1|920308_921442_+|ATP-grasp-domain-protein	unknown	unknown	gnl|CDD|379745
NZ_CP022310.1|WP_142191985.1|917170_917710_+|toxin-antitoxin-system,-toxin-component	unknown	unknown	unknown
NZ_CP022310.1|WP_142191922.1|918545_919223_-|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl|CDD|225524
NZ_CP022310.1|WP_142191920.1|916482_917139_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|376540
NZ_CP022310.1|WP_142231222.1|930125_932201_+|transketolase	unknown	unknown	gnl|CDD|223100
NZ_CP022310.1|WP_142191915.1|911829_912720_-|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl|CDD|188630
NZ_CP022310.1|WP_142231218.1|912716_914087_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|273584
NZ_CP022310.1|WP_142231221.1|919219_920074_-|metallophosphoesterase	unknown	unknown	gnl|CDD|224327
NZ_CP022310.1|WP_142231219.1|914372_915536_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223737

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142191926.1|923149_924343_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	9.6849e-52
NZ_CP022310.1|WP_142191986.1|929045_929960_-|helix-turn-helix-domain-containing-protein	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	1.99318e-21
NZ_CP022310.1|WP_142191924.1|920308_921442_+|ATP-grasp-domain-protein	gnl|CDD|379745	pfam15632, ATPgrasp_Ter, ATP-grasp in the biosynthetic pathway with Ter operon. This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter stress response operon and are predicted to be involved in the biosynthesis of a ribo-nucleoside involved in stress response.	2.63435e-49
NZ_CP022310.1|WP_142191928.1|925140_927249_+|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	3.52415e-81
NZ_CP022310.1|WP_142191915.1|911829_912720_-|dihydrodipicolinate-synthase-family-protein	gnl|CDD|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	5.00541e-85
NZ_CP022310.1|WP_142191929.1|927533_928940_+|carbohydrate-binding-protein	gnl|CDD|185691	cd02182, GH16_Strep_laminarinase_like, Streptomyces laminarinase-like, member of glycosyl hydrolase family 16. Proteins similar to Streptomyces sioyaensis beta-1,3-glucanase (laminarinase) present in Actinomycetales as well as Peziomycotina. Laminarinases belong to glycosyl hydrolase family 16 and hydrolyze the glycosidic bond of the 1,3-beta-linked glucan, a major component of fungal and plant cell walls and the structural and storage polysaccharides (laminarin) of marine macro-algae. Members of the GH16 family have a conserved jelly roll fold with an active site channel.	2.54619e-129
NZ_CP022310.1|WP_142191927.1|924339_925011_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.12832e-70
NZ_CP022310.1|WP_142191925.1|921615_922953_-|6-phospho-beta-glucosidase	gnl|CDD|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP022310.1|WP_142231216.1|910149_910818_-|FCD-domain-containing-protein	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.01062e-42
NZ_CP022310.1|WP_142191917.1|914076_914376_-|(2Fe-2S)-binding-protein	gnl|CDD|379229	pfam13510, Fer2_4, 2Fe-2S iron-sulfur cluster binding domain. The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.	1.46931e-30
NZ_CP022310.1|WP_142191919.1|915600_916260_-|hypothetical-protein	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	1.61101e-07
NZ_CP022310.1|WP_142231222.1|930125_932201_+|transketolase	gnl|CDD|223100	COG0021, TktA, Transketolase [Carbohydrate transport and metabolism].	0
NZ_CP022310.1|WP_142191922.1|918545_919223_-|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl|CDD|225524	COG2977, EntD, Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism].	5.85139e-56
NZ_CP022310.1|WP_142191920.1|916482_917139_+|helix-turn-helix-domain-containing-protein	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	3.81259e-07
NZ_CP022310.1|WP_142231217.1|910814_911816_-|proline-racemase	gnl|CDD|368491	pfam05544, Pro_racemase, Proline racemase. This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Trypanosoma cruzi PA45-A, a protein with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.	3.49408e-154
NZ_CP022310.1|WP_142231218.1|912716_914087_-|FAD-dependent-oxidoreductase	gnl|CDD|273584	TIGR01372, sarcosine_oxidase_alpha_subunit, sarcosine oxidase, alpha subunit family, heterotetrameric form. This model describes the alpha subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason.Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines].	7.13575e-33
NZ_CP022310.1|WP_142231221.1|919219_920074_-|metallophosphoesterase	gnl|CDD|224327	COG1409, Icc, Predicted phosphohydrolases [General function prediction only].	4.89536e-23
NZ_CP022310.1|WP_142231219.1|914372_915536_-|FAD-dependent-oxidoreductase	gnl|CDD|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	4.32039e-60

Protein sequences

>NZ_CP022310.1|WP_142231220.1|917859_918099_+|hypothetical-protein
MPTAVLTDRERTAVQAYLRLLHTVRAAFDTPSASPDTPGPPLVPPAVLAEAETALARAGLAGNEAEFFRMLRDWRRAEP
>NZ_CP022310.1|WP_142191985.1|917170_917710_+|toxin-antitoxin-system,-toxin-component
MRRLCGELVAELTLPAPARPADLYAALCEAMSRRRGRPVLFRTAVFPPGTASGLWLDMTDLDLVVVEERTAPDHQLVILGHELWHMKAGHCGHHVAGAEVATRLLGDTPDEDALRATVLRVAARTRFDLAEEKDAEAFGLLLASKCRTWLAGSSLRGPVQRDHLAGRIGASLGYLGPQG
>NZ_CP022310.1|WP_142191920.1|916482_917139_+|helix-turn-helix-domain-containing-protein
MTGGFEGPGTAPTTALPAVVARVTALADRLGVAQSEVFDVGRLSVASGVPEPVVKALLSGRPAGEPDVQARFLQRLDLLRRTRLKPNGRKYTQQEIADGAGMSRQQAGALINGDRRPTMEHCDAIQRFFRVHAGFLTAEDPEALTGALQHTEQELLQKLADRERAAAAPADDPLERLLQDHGVRGIAWRAAQLPTDQHRDKVAEWLDMLLESVQRPKS
>NZ_CP022310.1|WP_142191919.1|915600_916260_-|hypothetical-protein
MAHQAGGQRPAPRPTTGTPEAQAYLRDYADLLEAAPHPSLVVDHRWDVLLTNSAFRALFQDVEPHPTALPVDNFLRFVLFHPDAATVLGDHESSWCLPMLAHFAQTVERYGHDRGLQSIRRDIAQDPIMEAAYRYGVPHWLRVVGEQAAEHDGAVRPLLHPDPRWGATDCRIVVETTRTLRDMDCARLTLVLREAPRVSAGHRRARRAASHLRVVRTAD
>NZ_CP022310.1|WP_142231219.1|914372_915536_-|FAD-dependent-oxidoreductase
MSESLTCDVVVVGAGMTGAACALYAARAGLSVTVVDRGPVAGGTTGAGEGNLLVSDKAPGPELQLALLSLALWAETAEELGAAVEYEAKGGLVVARTPEALDSLRAFAAAQRAAGVTADPVTADGLHDLEPRLAPGLAGGVHYPQDAQVMPALAAAHLLRASGARLLTGREVTRVLRAPGGAVRGVRTDRGDVQAPAVVNAAGTWGGELAARAGVSLPVLPRRGFVLVTEPLPPRIRHKVYAADYVADVASDSAALQTSPVVEGTAAGPVLIGASRERVGFDRSLSLPAVRALAAGATALFPFLSGVRALRTYAGFRPYRPDHLPAIGPDPRAPGLYHACGHEGAGIGLATGTGLLIAQSLTGRTPALDLTPFRPDRFPRTTKETAR
>NZ_CP022310.1|WP_142191917.1|914076_914376_-|(2Fe-2S)-binding-protein
MNPLELAGARPGPAFTVTFDGRRIEALPGRTVAAVLWAAGITSWRATRDGGRPRGVFCGIGVCFDCLVTVNGRPNQRACLVPARPGDDIRTQEGTGHAH
>NZ_CP022310.1|WP_142231218.1|912716_914087_-|FAD-dependent-oxidoreductase
MPTDLAVIGAGPAGLAASLAACARGVRVTLIDAAPEPGGQFHRQPAAGLRAARPEALHHRWRTWTRLRDGLAAGSVRLLTEHHVWGVERTSGGLTVHALLGPDQEEPAEVHARAVLLATGGHETVLPFPGWTLPGVVTAGGAQAMLKGGLVTPGRTAVVAGTGPLLLPVAAGLAAAGVTVAALVESAGPERLPRHVVTLAGKFPEAAGYAARLLRHRVPFLARRTVVRAHGDERLTGVTVAALDAHGGVRPGTERLLPCDTLAVGHGMLPHTDLAEALGCRLDGLTVAVDEEQRTDVPGVWAAGEATGVGGAALALAEGHIAGRSVAARLRGTAPDPRQWAPAARVRARARRHAAALGSVYAPPARWTDRVTDDTVVCRCEEVTAGAVREALALGAGDARTVKLLTRAGMGWCQGRMCGPAVAGLAGCEPTPSRRPFARPVPLGVLAGQHSEEGHS
>NZ_CP022310.1|WP_142191915.1|911829_912720_-|dihydrodipicolinate-synthase-family-protein
MTDHRPWRGVLVATALPLNDDLTVNHDRYAEHCARLVADGCDGVVPNGSLGEYQVLTAEERARVVETAVAAVGGERVMPGVAAYGSAEARRWAEQAAEAGCRAVMLLPPNAYRADERSVLAHYAEVAAAGLPVVAYNNPVDTKVDLVPELLARLHGEGYVQAVKEFSGDVRRAYRIAELAPELDLLAGADDVLLELAVAGAKGWVAGYPNALPRSCVELYRAAAAGDLATALPLYRRLHPLLRWDSRVEFVQAIKLSMDLTGRYGGPCRPPRVPLEPGQEAAVRAATEQALAAGLA
>NZ_CP022310.1|WP_142231217.1|910814_911816_-|proline-racemase
MRSKLVLHAVDSHTEGMPTRVITGGIGTIPGATMNERRLYFRDHRDHIKQLLMNEPRGHSAMSGAILQPPTRPDCDWGVVYIEVSGYLPMCGHGTIGVATVLVETGMVEVVEPVTTIRLDTPAGIVVAEVAVEDGAATAVTLRNVPSFAVALDRQATLPDGRTVTYDLAFGGNFYAILPLDRLGLPFDRSRKDDILAAGLFLMEAVNAAGEPVHPEDPSIRGCHHVQVTAPDATARHSRHAMVIHPGWFDRSPCGTGTSARMAQLHARGELPLHTEFVNESFIGTRFTGRLLGTTEVAGRPAVLPSFTGRAWITGTAQYLLDPRDPFPAGFVL
>NZ_CP022310.1|WP_142231216.1|910149_910818_-|FCD-domain-containing-protein
MTGTSPALRSIGGRGPSYRERVADALRAALIAGELRPGEVYSAPGLAARFGVSATPVREAMLDLAKQGLVDTVPNKGFRVTAVSDRQLDEYTHVRSLIEIPTTADLAVTADPVALEALRPVAEEIVTAAAAGDLIAYVEADQRFHLGLLALAGNGHLVEVVRDLRQRARLYGLTALVEQGRLEASAEEHLELLDALLARDPEAVRAVMTRHLGHVRGLWAAP
>NZ_CP022310.1|WP_142191922.1|918545_919223_-|4'-phosphopantetheinyl-transferase-superfamily-protein
MIEELLPQTVVAVAAYGDEGVDAPLYPEEEALVARAVLKRRREFTAVRSCARRAMEKLGVPPQPVLPGERGAPVWPEGVTGSMTHCQGYCAAALVRAGDLASLGVDAEVHGPLPEGVLDAVALPQEVTRLERLSGQHPAVHWDRLLFSAKESVYKAWFPLTRKWLDFSEADIEIVPDPDAATRGGFRATLLVPGPRVGTRVLDHFTGRWTTRDGLIATAIAVPHT
>NZ_CP022310.1|WP_142231221.1|919219_920074_-|metallophosphoesterase
MSGTDGGQLWAISDLHIGYDENRALVERMRPESDEDWLLVAGDVAETVEDIVWALKTLAGRFAKVVWVPGNHELWTHPRDAVTLRGAARYDHLVEQCRALGVLTPEDPYPVWDGPGGPVTVAPLFLLYDYSFLPPGCATKDEGLAYAHKTGVLCTDEHLLHPDPYPSREAWCRARVAETERRLAALPDDRPLVLVNHYPLHRHPTDVLWYPEFAMWCGTVLTDDWHRRFNLHTMVYGHLHIPRTTWQDGVRFEEVSVGYPREWRKRDQPPGRLRRIVPREDGKR
>NZ_CP022310.1|WP_142191924.1|920308_921442_+|ATP-grasp-domain-protein
MVSRVRVWLNRTYAENVFFMDQLRRNPSDRAVEIHATHGDPDSPVLAAADTAELEPEGLSPAAYVEYALAQCERRGIDVFVPRLHQAAVVAHRAEFEAVGTALLAPPPEAVAVFRDKVIAYEAVQAIGVPVPPWWRVRDADELVAAVEELESRGLRACFKPASGAGGVGFRVITRTPFSLTQLNGFPSPYVPLDLVLEAVRQAEEPVDWLVMPRLEQPEVSVDCLTGPDNRIRLAVGRTKNGRRRGFTLHEQWLEPARRIAEGFGLHHLSNIQFRMLGDRPVLMDVNTRPAGGLHQLSLCGVNAPWAAVRLALGEDPGEIVPPFLGQDYTVVSGPRPLLPVPLPQQLADLPAASPALDAVPAPAASVEPRTATGARS
>NZ_CP022310.1|WP_142191925.1|921615_922953_-|6-phospho-beta-glucosidase
MRLTILGGGGFRVPLVYGALLGDRAEGRVTRVVLHDVDGGRLRAITRVLAEQAAGVPDAPEVTATTDLDEALRGADFVFSAIRVGGLEGRADDERVALAEGVLGQETVGAGGIAYGLRTVPVAVDIARRVARLAPDAWVINFTNPAGLVTEAMSRHLGDRVIGICDSPVGLGRRIARVLGARPQEAWIDYVGLNHLGWVRGLRVAGRDELPRLLDDPVLLGSFEEGRLFGADWLRSLGAVPNEYLHYYYFNREAVDAYRRAERTRGAFLHDQQARFYAGTDDPAVSALDLWERTRAEREATYMAENREAAGAGEREADDLSGGYEKVALALMRAVARDERTTLILNVRNRGTLAPLDADAVIEVPCLVDANGAHPVAVDPLPGHATGLVCAVKAVEREVLAAARSGSRTTAVKAFALHPLVDSVNVARRLVDGYTAVHPGLAYLN
>NZ_CP022310.1|WP_142191926.1|923149_924343_+|sensor-histidine-kinase
MSLRSAFTPVVTRWRSANPYALDTALAALVLFAVSLHWIFPGKGDEQLTWQGWLLAAATAVPLVWRRRSPCASAWAVSAATPAQALYHAPPPDVMYGGMVVLYTMAALARPWQRRLMLTGWVVGVVVTMQHQADKQPFEYAFHLMGLVCAYALGVLARVQRAYTTELEDRARRLERERAADTARARAEERSRIARDMHDILAHAVSLMVVQAEAGPVVVRKDPERAEATFDTIATTGRDAMAQLRRILGVLKEERPDGEVARLPQPSVAALPRLVRQVQESTGLRTELRTTGEPCPLPSDTEIAAYRVVQEALTNTVKHARASRALVELDWAEDHVTLTMTDDGRGPSAPVGGHGLIGIRERAAACGGSAETGRGPDGGFRVVVRLPAAGDRQGALG
>NZ_CP022310.1|WP_142191927.1|924339_925011_+|response-regulator
MSIRVVVADDQELVRAGFGMILDAQDDIEVVAEAGDGEEAVAAVRRHGPDVLLLDIRMPVMDGLEAARRVCAQSCCKVVMLTTFDLDEYVYEALYAGASGFLLKDVRRDDLVHAVRVVAAGDSLLAPAVTRRLVADIVRRRRERSAAEAAPPQRLDALTAREVETLRLLARGLSNAEIATTLFVSEHTVKTHVSNVLSKLGLRDRVQAVICAYETGLITPGSP
>NZ_CP022310.1|WP_142191928.1|925140_927249_+|MMPL-family-transporter
MLSALARAATRRPLTVMLLWGLFLLLGFGLGTGVFARLSDNVPEVPGTESESAAQYLDREDPVGESISGVVAGTAVSDPALRADVERAVADVRKVAGVAAVPDPYTTRGLTAEDGQALIIPVTLEGGLDDDDAERTLDAAAERIREIDAPDVHVSGGPLLGQQLTEQAQKDVKFAELVSLPVVLALLLVVFGGLRSALLPLVIAVSGIAGAFLALFLFSEVTDISVYAIQVTTMLGLGLAVDYALLMLMRFREERRHTEDVVEAVHRTVAAAGRTVLFSGLTVAVSLTGLLVFPSVFLRSMGLAVAAVVVIDMLAALTLLPALLTRFGGRIPPAKDRPEGEEGRFFARLARFAARRRIAVLAVAVPVLLVLAVPMAGMKIAIGDARQLPTTSEARQLHDTVGDHFPPGAGVTPVTVVVRPGTDAATVDGIRSLSPASSARELPGGATVLEIRPPGEADGKEATDLVERVREVRGDEPVEVTGPAARLVDFREMLGERAPWAALTVLAGIFVLLFAFTGSVLLPLRTIVTTLLSLAAALGAVVWVFQDGHLAGLLGTEGLGALSLTAPPLIIAIAFGLAMDYELFILARMGEARRHSGDDAQAVVDGLRRSGRVVTCAALLLAVVFAAFMTGGFSPILQIGLGLTLAVLIDATVVQMLLVPATMSLLGRRAWWAPAPLRRVHDRFGLREEPVEEPRPRVPTGV
>NZ_CP022310.1|WP_142191929.1|927533_928940_+|carbohydrate-binding-protein
MRDTSGTPRMLRRPRPLRRALLAVVSTLALAAGAATAASPSASASVPPPPSGWTQVFADDFDGPAGSGVNTSNWQYATGKGYPGGPANWGTGEIETMTSSTDNVSLDGSGNLRITPRRDASGNWTSGRIETNRTDFQPPAGGKLRVESRIQVPNVTGAAAKGYWPAFWMLGAPYRGNYWNWPAVGELDIMENTQGNNTVFATMHCGTSPGGPCNETSGIGGSTTCQGTTCQAGFHTYRMEWDRSTSVEEIRFYLDGVNYHTVRENQVDATTWSNATDHGFYIILNVAMGGGFPDAFGGGPDAGTQPGHSMLVDYVQVLSSGGGGTTPPPTGNRDAYSAIQAESYDAQSGVMTESTSDSGGGQNVGALANGDWLQFKGVNFGSNAARQFSARVASGAGANISGLVEVRLDSRSNAPIGSFAVGNTGGWQSWRTIPANISNVTGTHDVYLTFTSGQPADFVNVNWFTFGH
>NZ_CP022310.1|WP_142191986.1|929045_929960_-|helix-turn-helix-domain-containing-protein
MAGSNPRSGGPDGGDDDGDGIRTFPFPVDRSVLGVGMQIAPMGPDRTWRADAPLDRVHRIDFHIVMLFDAGPVRHMIDFTEHEAAAGDLLWIRPGQVHRFSRGSEYRGTVLAMQPGFLPRATVEATGLYRYDRQPLLHPDPAQLAALRAALDQLRREYEDTATLPLSLHTAVLRHSLTAFLLRLAHLAASSAEADRERSGTAFTRFRDAVEHGFATNHSVSAYADALGYSRRTLVRAVRAATGETPKGFIDKRVVLEAKRLLAHTDLPIGRVGAAVGFPDAANFSKFFHQHTDTTPAAFRAELR
>NZ_CP022310.1|WP_142231222.1|930125_932201_+|transketolase
MSTQTPHPLNWTDLDRRAVDTARLLAADAVQRVGNGHPGTAMSLAPAAYTIFQKVMRHDPADPEWTGRDRFVLSPGHTSLTLYTQLYLAGYELDLDDLKAFRTHGSRTPGHPEYGHTAGVETTTGPLGQGVANAVGMAMAARYERGLFDPDAPEGQSPFDHTVWAVVSDGDLQEGVSAEASSLAGHQRLGNLVLLYDDNHISIEGDTATAFSEDVLKRYEAYGWHVQRVEPREDGDIDVHALYAALTAARAETGRPSIIAMRTIIAWPAPNARNTEASHGSALGADEVAATKRLLGFDPGRSFEVEADVLAHTRRALDRGAEAHAAWDKRIADWREAHPERAGLFDRILAGRLPDGWQDVLPVFEPGKAVATRAASGKVLQALGGVLPELWGGSADLAGSNNTTIDKTSSFLPAGNPLPEADPYGRTIHFGIREFSMAAEMNGIALHGNTRVYGGTFLVFSDYMRNAVRMSALMQLPVTYVWTHDSIGLGEDGPTHQPVEHLASLRAIPGLNVVRPADANETAIAWAEIMKRHATRPAPHGLALTRQAVPVYAPNPDAAKGGYVLAEASGGTPDVILVATGSEVQLAVAAREVLEGEGVGTRVVSMPSVEWFEEQPRAYRERILPPSVKARVAVEAGVGLTWYRFTGDAGRIVSLEHFGASADAQTLFAEYGFTTDHVVAAARESLAAARG

Crispr_ID: NZ_CP022310_2

• CRISPR_ID: NZ_CP022310_2
• CRISPR_location: 1247863-1247963
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_2

Consensus_repeat	Method
GCACCACCCGCACCGTCCTCGGC	CRISPRCasFinder

spacers of NZ_CP022310_2

>2.1|1247886|55|NZ_CP022310|CRISPRCasFinder
ACCACCCGCCGTCCTCGGCACCACCCGCCGTCCTCGGCACCACCCGCCGTCCTCG

CRISPR arrays and Neighbor proteins around NZ_CP022310_2

CRISPR arrays

The CRISPR arrays of NZ_CP022310_2

>merge|NZ_CP022310|2|1247863-1247963|CRISPRCasFinder
GCACCACCCGCACCGTCCTCGGCACCACCCGCCGTCCTCGGCACCACCCGCCGTCCTCGGCACCACCCGCCGTCCTCGGCACCACCCGCACCGTCCCCGGC

>NZ_CP022310|2|2|1247863-1247963|CRISPRCasFinder
GCACCACCCGCACCGTCCTCGGC	ACCACCCGCCGTCCTCGGCACCACCCGCCGTCCTCGGCACCACCCGCCGTCCTCG
GCACCACCCGCACCGTCCCCGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142231359.1|1254344_1256432_-|hypothetical-protein	unknown	unknown	gnl|CDD|226729
NZ_CP022310.1|WP_142231353.1|1244461_1244866_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142231348.1|1233577_1234231_+|HAD-IA-family-hydrolase	unknown	unknown	gnl|CDD|372595
NZ_CP022310.1|WP_142234043.1|1253816_1254251_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142192171.1|1234526_1235126_+|deaminase	unknown	unknown	gnl|CDD|334719
NZ_CP022310.1|WP_142192182.1|1260589_1261738_-|ROK-family-glucokinase	unknown	unknown	gnl|CDD|273246
NZ_CP022310.1|WP_142231360.1|1260014_1260593_-|sugar-kinase	unknown	unknown	unknown
NZ_CP022310.1|WP_142231357.1|1251556_1252567_+|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|334028
NZ_CP022310.1|WP_142234042.1|1236379_1239433_-|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|238624
NZ_CP022310.1|WP_167530002.1|1249722_1251264_+|phytoene-desaturase	unknown	unknown	gnl|CDD|274273
NZ_CP022310.1|WP_142231355.1|1246076_1247807_+|CocE/NonD-family-hydrolase	unknown	unknown	gnl|CDD|225487
NZ_CP022310.1|WP_142192174.1|1243648_1244374_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142192184.1|1262641_1263724_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224093
NZ_CP022310.1|WP_142231356.1|1248574_1249726_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|173833
NZ_CP022310.1|WP_142231358.1|1253189_1253600_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142231352.1|1241832_1243257_-|alpha-L-arabinofuranosidase	unknown	unknown	gnl|CDD|281639
NZ_CP022310.1|WP_142231351.1|1240155_1241691_-|family-43-glycosylhydrolase	unknown	unknown	gnl|CDD|350129
NZ_CP022310.1|WP_142231349.1|1235228_1236185_+|IS481-family-transposase	unknown	unknown	gnl|CDD|366234
NZ_CP022310.1|WP_142231354.1|1245254_1246022_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367243
NZ_CP022310.1|WP_142192183.1|1261802_1262645_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224053

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142231359.1|1254344_1256432_-|hypothetical-protein	gnl|CDD|226729	COG4279, COG4279, Uncharacterized conserved protein [Function unknown].	1.36784e-43
NZ_CP022310.1|WP_142231356.1|1248574_1249726_+|polyprenyl-synthetase-family-protein	gnl|CDD|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	1.86241e-63
NZ_CP022310.1|WP_142231348.1|1233577_1234231_+|HAD-IA-family-hydrolase	gnl|CDD|372595	pfam13419, HAD_2, Haloacid dehalogenase-like hydrolase.	3.1402e-37
NZ_CP022310.1|WP_142192171.1|1234526_1235126_+|deaminase	gnl|CDD|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	6.06419e-19
NZ_CP022310.1|WP_142231357.1|1251556_1252567_+|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|334028	pfam00355, Rieske, Rieske [2Fe-2S] domain. The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilizes the protein.	4.99011e-18
NZ_CP022310.1|WP_142234042.1|1236379_1239433_-|amidohydrolase-family-protein	gnl|CDD|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	6.76666e-25
NZ_CP022310.1|WP_167530002.1|1249722_1251264_+|phytoene-desaturase	gnl|CDD|274273	TIGR02734, Phytoene_desaturase_lycopene-forming, phytoene desaturase. Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP022310.1|WP_142231355.1|1246076_1247807_+|CocE/NonD-family-hydrolase	gnl|CDD|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	5.89635e-96
NZ_CP022310.1|WP_142192183.1|1261802_1262645_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	2.13611e-100
NZ_CP022310.1|WP_142192184.1|1262641_1263724_-|ABC-transporter-permease	gnl|CDD|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	1.47157e-58
NZ_CP022310.1|WP_142192182.1|1260589_1261738_-|ROK-family-glucokinase	gnl|CDD|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	2.43686e-88
NZ_CP022310.1|WP_142231352.1|1241832_1243257_-|alpha-L-arabinofuranosidase	gnl|CDD|281639	pfam03664, Glyco_hydro_62, Glycosyl hydrolase family 62. Family of alpha -L-arabinofuranosidase (EC 3.2.1.55). This enzyme hydrolyzed aryl alpha-L-arabinofuranosides and cleaves arabinosyl side chains from arabinoxylan and arabinan.	4.89277e-167
NZ_CP022310.1|WP_142231351.1|1240155_1241691_-|family-43-glycosylhydrolase	gnl|CDD|350129	cd18617, GH43_XynB-like, Glycosyl hydrolase family 43, such as Bacteroides ovatus alpha-L-arabinofuranosidase (BoGH43, XynB). This glycosyl hydrolase family 43 (GH43) subgroup includes enzymes that have been characterized to have alpha-L-arabinofuranosidase (EC 3.2.1.55) and beta-1,4-xylosidase (beta-D-xylosidase;xylan 1,4-beta-xylosidase; EC 3.2.1.37) activities. Beta-1,4-xylosidases are part of an array of hemicellulases that are involved in the final breakdown of plant cell-wall whereby they degrade xylan. They hydrolyze beta-1,4 glycosidic bonds between two xylose units in short xylooligosaccharides. These are inverting enzymes (i.e. they invert the stereochemistry of the anomeric carbon atom of the substrate) that have an aspartate as the catalytic general base, a glutamate as the catalytic general acid and another aspartate that is responsible for pKa modulation and orienting the catalytic acid. Also included in this subfamily are Bacteroides ovatus alpha-L-arabinofuranosidases, BoGH43A and BoGH43B, both having a two-domain architecture, consisting of an N-terminal 5-bladed beta-propeller domain harboring the catalytic active site, and a C-terminal beta-sandwich domain. However, despite significant functional overlap between these two enzymes, BoGH43A and BoGH43B share just 41% sequence identity. The latter appears to be significantly less active on the same substrates, suggesting that these paralogs may play subtly different roles during the degradation of xyloglucans from different sources, or may function most optimally at different stages in the catabolism of xyloglucan oligosaccharides (XyGOs), for example before or after hydrolysis of certain side-chain moieties. It also includes Phanerochaete chrysosporium BKM-F-1767 Xyl, a bifunctional xylosidase/arabinofuranosidase. A common structural feature of GH43 enzymes is a 5-bladed beta-propeller domain that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	9.39096e-162
NZ_CP022310.1|WP_142231349.1|1235228_1236185_+|IS481-family-transposase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	6.75713e-20
NZ_CP022310.1|WP_142231354.1|1245254_1246022_-|TetR-family-transcriptional-regulator	gnl|CDD|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	1.78508e-12

Protein sequences

>NZ_CP022310.1|WP_142231355.1|1246076_1247807_+|CocE/NonD-family-hydrolase
MPSRTPDAGAGPDRMRPAGRPPLSARLMRATWRGLPARRHAVGREAGLVVPAADGSPLITDHYFPRTRGDFPTLLVRSPYGRGLPWAPMYGLLFAEQGFHVVLQSCRGTGGSGGAFDLWRNEAADGLATVAWLRGRPWFDGTLGTVGPSYLGYVQWALAADPPPELKAMVVQVGLHDPYALFHADGVPRLENALAVGVGMTYQHQGLVPSVRAALRLRRRLRTATTALPLRGAYASALGTEPPWLADVLAHPDAEDPYWRGASSAGAAERLRVPTALITGWHDTLADQTFEQYGRLRRAGCPASLLVGPWTHTSALQQGWPEVFAESLAWLRAHLCADPSGLRPTPVRVHLGGANAWRDLADWPPARTTASWYPLPDGRLTRQAPTDSTPVTAFRYDPADPTPSLGGPLLSGTAGARDNSVLEARDDVLTFTGPPLTEPLDVLGPVAARLSVSTDTGHAHVFTRLCDVDAQGRSVNVCDGLSSLRTTGGTAAQVTVPMGTTAHRFAVGHRIRWQISGGAHPRFARNPGTGEPPLDATALTPTHITLYTDSALRLPHGSRPALLPAPPPHDRPAHGR
>NZ_CP022310.1|WP_142231354.1|1245254_1246022_-|TetR-family-transcriptional-regulator
MAPARAATANPGKEHATVSDDARSGAAGVDPEQLWLRPAKPRRGRRPSFSREAITAAAVALADAEGLEAVTMRRVAAEVGAGVMSLYSYAPDKETLLELMVDHVSAELEITDPLSGDWRADLKTVAHLQRAHMLRHPWLPAALSTRRVPGPRTLAFLEHALAALRPTGLDGAAKLEVFAQLTAFVAGHVAHELAQSAASRSPERAAAEARYLAAVAADGRHPELAEALSAPGRPLTPDATFTRFLNRLIDGLDTD
>NZ_CP022310.1|WP_142231353.1|1244461_1244866_-|hypothetical-protein
MSGRTASVAVLAVLVTVSSCGTPSERRGRVTEDVTRFERALDAGQPAQLCAALAPSTREELEQAAKTRCERAIGEQGLPRAGAVRSVDVYGGQARVVLEHDTVFLARFTDGWKVTAAGCRPRPQQPYQCEIKSG
>NZ_CP022310.1|WP_142192174.1|1243648_1244374_-|hypothetical-protein
MSAAPETREGTAPIGRRVRLFLRHNSLGLFFVTAFLLALSGQAVAGHAEFNNQLVADGLEPIGFGAYLTTSDFGVDVMENWQSEYLQFFLYIFGTVYLLQRGSPESKELGRAGIESDQDQMVGEHAADDSPRWAAATGWRTAVYSRSLGLVMGTIFLLSFLAQSVTGVAAYNEQQLRQLQAPVSWSAYLSSADFWSRTLQNWQSELLAVASMAVLAIYLRQRGSPESKPVGASHSATGVEG
>NZ_CP022310.1|WP_142231352.1|1241832_1243257_-|alpha-L-arabinofuranosidase
MRRRSFGRGRLSVVLAAAVTALVALAAALVANPAQAATSGALRGVGSDRCLDVPGAAQADGTLVQIYDCWGGSNQQWTSTDTGQLTVYGSKCLDVPGHSTAAGTRVQIWTCSGGANQQWRVNSDGTVVGVESGLCLEAAGARTANGTAVQIGTCNGGSNQKWTGLPGTPPTDGACSLPSTYRWTSTGVLAQPAHGWVSVKDFTTVTHNGKHLVYASNVSGSSYGSMMFSPFTNWSDMASAGQTGMNQAAVAPTLFYFAPKNIWVLAYQWGSWPFIYRTSSDPTNPNGWSAPQPLFTGSISGSDTGPIDQTLIADGQNMYLFFAGDNGKIYRASMPIGNFPGNFGSSYTTIMSDTKANLFEGVQVYKVQGQNQYLMIVEAMGANGRYFRSFTASSLSGSWTPQAASESNPFAGKANSGATWTNDISHGDLVRNNPDQTMTIDPCNLQFLYQGKSPTAGGDYNQLPWRPGLLTLRR
>NZ_CP022310.1|WP_142231351.1|1240155_1241691_-|family-43-glycosylhydrolase
MPTYDNPVISGFHPDPSVCRVGDDYYLVCSSFEYFPGLPIFHSKDLVHWEQIGNVLDRPGQLPLPLPGAKASGGLYAPTIRHHDGRYWVINTNIDGGGNFVVSAERPEGPWSDPVWIDLHGIDPDLAWEEDGTCWCAFSGPAGGINTARIDPVEGEVLEGPFATWSGSGLKYPEAPHLYRIGDWWYLLIAEGGTERGHSVSVARGRSPRGPWEGAPANPLLSHSGTPRSIQNTGHADLVEAPDGSWWMVLLGVRPRGFTPDVHVLGRETFLTPVEWDADGWPRIGPVPESHAAPGGAWHPVPAPPARDDFDDSALAPHWISPFARPAGSWSLTERPGRLVLRATGPTLDRPGYTFVGRRQQHHDCRATAEIDPGTGRGGLCVRLDEAHHYELEVGNGEAAVVARIGPLRQTVAARPVPSGPLTLTVTIRTSDLVPASPELTDGGTTGPDTVAFWIGDPDAPDARPLAELDGRYLSTEVACGFTGRVIGMYATEGTVAFDWFEYAPVPAPPA
>NZ_CP022310.1|WP_142234042.1|1236379_1239433_-|amidohydrolase-family-protein
MTSLAGPSAVATGTRTDADGDLRLGTGTTFAARISPDGRWIALDLLGVLWVMPASGGQARRLTSDLFDIAQPDWSPDSSRLVFQSYRDGVFDLWTVRPDGSGLRQLTEGPYDHREPRWSPDGHTILFSGDASGSYAIHTYDVDSGRVGALTDGPGQEYEPAWSPDGNRVAFVVDNTRIDVVDRTTGRRSTHVTVPAGQVIHQPEWTPDGTGLVHHLTYDGRCHLMRGDTPLVDDQETFPFRVSWLDGERFLYTADGRIHVRSLTGSGTRTIGFSAAVTTRRPRYTRRRSDFESTGPRPVRGIGSPVLSPDGEHIAFRALNDIYVMRIGRAPQPLTRDHWWTCDPAWSPDGKRLAYSTDRGGTLDLWIRDLDTGRDRQLTDLGTRAAVSAAWSPDGKEIAFLDQDGALWTADVASGDVRRVFTATFEPGRPTWSPDGRTIALAAVKPYSARFREGLSQILLVDRTTGQGRYVEAVAGRSIQTRGDDGPVWSPDGRRMAFAVASVLYTVDVAEDGTPVGEPRQITGEVTDAPSWSGDSRHLLYLNNGRLRLVPADGGRPRTVAVPLTWTAVRPPARTVVHAGRMWDGVRREIRRDVDIVVEGHRIRSVEPHDDRRAGQRIDARDRLVMPGLIDMHHHREMQGYAYGDRQGRLWLSLGVTTTRSPGSPAYHMVEEREATRSGARIGPRYFATGEAIDGPRIYYNFMRPTFTDAQLKLELERAKSLEYDLMKCYVRLPVMWHKRVVAFAHDAGIPVTSHYHYPAMAFGGDAMEHTGATNRFGYSRTVTPLGTGYSDITDLFVASDMARTPTLFGSTTLYREDRSLVEDHRVRTLNPPWRMAALRESADAAARTDQTARRANLRAQVRQALDIFRRGGRIVLGTDAPIDHAAVSLHMNLRAMVTYGFTPYEALVTATSLAGETLHEDLGRIAPGMYADLAVVDGDPLTDIKDAANVAQVLVSGIAHTVESLLQPFSETPPADSRKTAGSSVLPPVPDHPANRKFWWHGHQYVETARHACCSG
>NZ_CP022310.1|WP_142231349.1|1235228_1236185_+|IS481-family-transposase
MSHRNARLTFHGRRLLVERVRTGRPVAHVAAEMGISRVTAHKWVRRWRAEGEKGLHDRSSRPRTTPHRTAGAIEARVCRLRQDRKLGPARIGPILGLPASTVHRVLVRHGLNRLSFLDRPTGQVIRRYERDRPGELVHVDVKKLGRIPDGGGHRVLGRQAGRATRNGMGFDFIHSAVDDHSRLAYSEVHPDEKAATCAAFLRRAAAFFAASGIDRIERVLTDNAWPYRKSLAWQQALADLDAAGKLTRAYRPQTNGKVERFNRTLLDEWAYLRPYTSNTERTDALADFLHTYNHHRCHTALGGQPPISRVNNAAGRYN
>NZ_CP022310.1|WP_142192171.1|1234526_1235126_+|deaminase
MSELLVDFITSLDGYASGEGWPGFWGLEGPEYLAWLGEQPEATYLMGANTYRLMSGFAAGEVPKGQDEFRPEEEASVDELTRASKVVFSSSLEEPLTWANSTLVRDDAVEAVRAMKSGGSGLLSTIGSLSLCRSLLRAGLVDRFRVVMFPVITGATGKERIYDGYPDVALEMTGHRTFDGRIQLVEYKPRVLEHPPLGH
>NZ_CP022310.1|WP_142231348.1|1233577_1234231_+|HAD-IA-family-hydrolase
MREPLPDRSPSAVVWDMDGTLIDSSSAVPDAFIETVTALGGAVHSRAEVVALYSLGPPRAMLSRMLERPCRDEEVDLYHEILARCAAQVTTCPGVEAALDRLRHLVPMAVFTGASRRAADILLSAAGLRDHFPVVVGGDEIERPKPDPQGIQRACSLLRVPTGACVYVGDAPTDLEAARRAGALAAAAGWGHLYDASARADLVLDTPDDLAARLLTA
>NZ_CP022310.1|WP_142231356.1|1248574_1249726_+|polyprenyl-synthetase-family-protein
MLGLPPTAAAPAGPVDDPLTAPDAARAVGAVLEEIVQARLRESRAVDPVSARDLSERLAALVARGGKRLRTAFAFCGWRAAGGSGDTGPVLRTGAALELLQACALVHDDVMDGSLRRRGAPALHVQLARAHRASGMRGSAESFGTSAAVLAGDLALAWADDLLTETALGTPHGPRLHREWRAMRTEMVAGQYRDLHAQAARTSGADEALDIATLKSALYTVARPLALGAALAGADDRTTDALRAAGRCAGLAFQLRDDLLGAFGDPALTGKPADDDLRSRKPTYLLATARRLADAAGDHRAAAVLTADAEPPPEHPDHAVERIRAALRRTGAVEVVETKIGELAAASLRHFASCGARPAVRREFAALVERASGVVPRRAEEVA
>NZ_CP022310.1|WP_167530002.1|1249722_1251264_+|phytoene-desaturase
MRTVPGPSDHVVVVGAGLSGLACALHLLGAGRRVTVLERDAGPGGRAGRVDLGGFQVDTGPTVLTMPHLADEAFAAVGDSLRRRVELMPLHPAYRACFADGSSLDVHSDGEAMEAEVRRFAGPVAAAGYRALRQWLERLYRAQMRRFIDTNFDSPVQLLHPDLARLAALGGFGRLDGRIGRFLPDDRLRRVFSFQALYAGVAPGRALAAYAVIAYMDTVAGVWFPKGGMHALPRAMADAAADAGADLRWSAEVSTLERSAGRVRAVRLASGERIPCDAVVLTCELPAAYRLLGRTPRRPARLRHAPSAVVLHAGTDRTWSHLAHHTISFGAAWERTFDELTRSGELMSDPSLLITRPTAHDPALAPPGGHLHYVLAPCPNTTVGPSAEAWRDLGPRYRDRLVGELERRGLDGFADSVREELLVTPLDWTAQGHAAGSPFSVAHTFAQTGPFRPRNLVRGVENVVLAGCGTTPGVGVPTVLVSGKLAAARVTGGTGRRTGATHGRVAERVGGTR
>NZ_CP022310.1|WP_142231357.1|1251556_1252567_+|Rieske-2Fe-2S-domain-containing-protein
MSGRAGGRRWTPPLRRRRRGPGWAAQTPTWQRARPALIADALKRASARPSGNWFVVCASREVRAGGRPFGRTVGGAEVVLWRSDGGELRAGPGACPHLGAPLRDSRVVCGTLVCHWHGLALNGSPFAGWQPFPVHDDGVLVWVRLDEVGGEEPTARPVVPVRPAAGSGVDAVFTATGRCEPQDVVANRLDPWHGSWFHPYSFVDLTVVREPGGEEDDVFVVDVSFRVAGRLVVPVRAEFAAPEPRTVVMRITDGEGATSVVETHATPLTGPDDDRPRTAVIEAVVAVSDRPGFALARAAAPVLRPLMRRTAGRLWRDDLAYAERRWALRSTGRFPG
>NZ_CP022310.1|WP_142231358.1|1253189_1253600_+|hypothetical-protein
MAGAVLVACLGLVLYGVLGTEDGTGDDEPKVPTAAVTYEVTGEGSVDVSYLGRSEKGTATVERNVELPWKKTVQVPLGRPPTVGIVLDAEGGQARCALAIRGKHVQSSTASGSYGRATCAGELPAPPSTDPPADNG
>NZ_CP022310.1|WP_142234043.1|1253816_1254251_+|hypothetical-protein
MEIQGIKVERQATAETKRIIESDARVAAATANVCGSGYTISTGAARYGTYGTTYTWTNGTTTGDSYYDKPICAVFFNDTGYTRYMGIRLKDNYTSTADVEDFGAYRSYAGPVYQKRGYCGKAYSYMEIGGTAVVDNYLTVGSCN
>NZ_CP022310.1|WP_142231359.1|1254344_1256432_-|hypothetical-protein
MTPRPSDEAREALRAARERARRGPVPSGTPDHPHTGAEPSENRASDQPAAGAETTPGRTSDQPASSGQSATAPAPRPADEPRPADESRPADESRPARRPGDIAREALRSARAEALRARAEADDRPPRTRPAAPAPRLPRTTRGDRAADDRARAVRAALADAFRMPDAADDPQRDPAPADRPRRTATSRTTTPQAPTPPDTRPGRGTSGPPAPHTPAPDPAAPRDLSGPAHRDPAHTPRDGVRDSTPDPGDPAHSQASLEPAHAPAPMPHAPRSMAAPGRDGDHRRTFPAFPPRPSDGEGFAETWWGRAWVTALEDGALDAARLARGRGYAEQGHVDAITVTPGLVLAYVRGSRPRPYRVQVRLRTFGDADWERFLDAAAERPGHIAALLDKEMPQSLADCGFPLLPGPGDLDPRCSCPDSGHPCKHAAALCYQTARLLDADPFVLLLLRGRGEREVIDALSRLSAARAARAARDRDPEPLPGVRAAEVLARRDRVLPPLPAPLPPPPHPEQPPVYPASPGGPDPFALDQLATDAAARAHALLTTGRDPVGGLTLWHDAVRLAAARPGSGLTAATRALYSSLATAVGRTPAELARAVAAWRQGGRTGLAVLEEPWDPPAGRFDRARPLLLAADLPAFRPWRNRLTHPRGHVQLRLGRDNLWYAYESEPGHDDWWPRGTPDPDPVGALTGLDTPDDL
>NZ_CP022310.1|WP_142231360.1|1260014_1260593_-|sugar-kinase
MTAEFPQQAGVPEAPRPAEDRRHMIRRRALTLLIIVLLIGIPAGYLVISAGQSRASGKDKEARYSATGLTEGWPSKLQRRLYQVPIPNPAWWVASYETNNWKTSRLYVEFETTDAGLSAFLTAMGVQQGDLERDDITISDRDRDVTGWTFDGPGTWSGLVHEQENPAPTHDVVVNHDKPGYPRVYVVSRTVP
>NZ_CP022310.1|WP_142192182.1|1260589_1261738_-|ROK-family-glucokinase
MSTYRDFTAPIGSRRATVLRTVGTRERRSHLTAPRVPTVGIDIGGTKVMAGVVDADGNILERLRTETPDKSKSPKVVEDTIVELVLDLSDRHDVHAVGIGAAGWVDADRNRVLFAPHLSWRNEPLRDRIAGRLAVPVLVDNDANTAAWAEWRFGAGRGEDHLVMITLGTGIGGAILEDGQVKRGKYGVAGEFGHMQVVPGGHRCPCGNRGCWEQYSSGNALVREARELAAADSPVAYGIIEHVKGNIADISGPMITELAREGDAMCIELLQDIGQWLGVGIANLAAALDPSCFVIGGGVSAADDLLIGPARDAFKRHLTGRGYRPEARIVRAQLGPEAGMVGAADLARLVARRFRRAKRRRVERYERYERYAEARRTTQESL
>NZ_CP022310.1|WP_142192183.1|1261802_1262645_-|ATP-binding-cassette-domain-containing-protein
MTRTDPRTPLVELSGVGKHYGRVRALDGVSLEVHAGEITCVLGDNGAGKSTLIKIIAGLHGHDGGTLALDGEETRLTSPRDALDRGIATVHQDLAVVPLMPVWRNFFLGSEPRKGIVPFRRMDVDHMRRTTRTELLRMGIDLRDVDQPIGTLSGGERQCVAIARAVHFGAKVLVLDEPTAALGVKQSGVVLRYVSAAREQGLGVVLITHNPHHAYLVGDRFVLLKRGTMVGNHRRDGITLEELTRQMAGGNELDDLRHELQRRQGNGGEGEPPRPTGTRP
>NZ_CP022310.1|WP_142192184.1|1262641_1263724_-|ABC-transporter-permease
MSTTTAEVDEETVSRSSDTSDERFLRGAASPLLRRLLSRPELGSLAGAVAVFCCFALAADSFLRASSLGTVLYASSTIGIMAVPVALLMIGGEFDLSAGVLVTSSALMSSMVSYQMTANVWVGVGVSLLLTLALGAFNGVVLARTRLPSFIVTLGTFLMLTGLNLGLTKLISGTVSTKTIADMEGFAGARALFASSFTVGGMQIKVTVVWWLALVALGSWILLRTRAGNWIFAVGGNEHAARAVGVPVTATRTALYMGVALGAWICGQHLLFSYDVVQSGEGVGNELIYIVAAVIGGCLITGGYGSAAGSAVGALLFGMTSKGIVFAEWNPDWFTFFLGAMLLLATLLNTWVRRRAEATA

Crispr_ID: NZ_CP022310_3

• CRISPR_ID: NZ_CP022310_3
• CRISPR_location: 2887617-2887729
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_3

Consensus_repeat	Method
GCCGTTGCTGTAGGTGCTCTTGCGCCAGACGGCCG	CRISPRCasFinder

spacers of NZ_CP022310_3

>3.1|2887652|43|NZ_CP022310|CRISPRCasFinder
CGCCGGGGAAAGCCTCGGCGACCTCGACGCAGTTGCCGCCATC

CRISPR arrays and Neighbor proteins around NZ_CP022310_3

CRISPR arrays

The CRISPR arrays of NZ_CP022310_3

>merge|NZ_CP022310|3|2887617-2887729|CRISPRCasFinder
GCCGTTGCTGTAGGTGCTCTTGCGCCAGACGGCCGCGCCGGGGAAAGCCTCGGCGACCTCGACGCAGTTGCCGCCATCGCCGTTGCTGTAGCTGCTCTTGCGCCAGACGGCCG

>NZ_CP022310|3|3|2887617-2887729|CRISPRCasFinder
GCCGTTGCTGTAGGTGCTCTTGCGCCAGACGGCCG	CGCCGGGGAAAGCCTCGGCGACCTCGACGCAGTTGCCGCCATC
GCCGTTGCTGTAGCTGCTCTTGCGCCAGACGGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142193458.1|2888761_2888971_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142193448.1|2878967_2879390_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232002.1|2891742_2893362_+|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|225281
NZ_CP022310.1|WP_167530191.1|2879520_2881212_-|Ig-like-domain-repeat-protein	unknown	unknown	gnl|CDD|223893
NZ_CP022310.1|WP_142232006.1|2897850_2898420_-|ATP-binding-protein	unknown	unknown	gnl|CDD|225138
NZ_CP022310.1|WP_142231999.1|2887737_2888592_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP022310.1|WP_142231996.1|2884734_2885628_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP022310.1|WP_142231994.1|2883514_2884027_+|hypothetical-protein	unknown	unknown	gnl|CDD|379650
NZ_CP022310.1|WP_142232005.1|2896674_2897808_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235874
NZ_CP022310.1|WP_142193459.1|2888970_2889384_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NZ_CP022310.1|WP_142231995.1|2884054_2884747_+|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
NZ_CP022310.1|WP_167530033.1|2885843_2887322_-|hypothetical-protein	unknown	unknown	gnl|CDD|214549
NZ_CP022310.1|WP_142232003.1|2893469_2894546_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142193451.1|2883142_2883382_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142193446.1|2876215_2877148_-|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl|CDD|379142
NZ_CP022310.1|WP_142232000.1|2889384_2890356_+|SMI1/KNR4-family-protein	unknown	unknown	gnl|CDD|214864
NZ_CP022310.1|WP_142232004.1|2894856_2896419_+|solute-binding-protein	unknown	unknown	gnl|CDD|238119
NZ_CP022310.1|WP_142232001.1|2890527_2891733_+|AAA-domain-containing-protein	unknown	unknown	gnl|CDD|184118
NZ_CP022310.1|WP_142193447.1|2877679_2878891_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|181738
NZ_CP022310.1|WP_142231993.1|2881344_2882976_-|hypothetical-protein	unknown	unknown	gnl|CDD|128941

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142193459.1|2888970_2889384_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.39759e-16
NZ_CP022310.1|WP_142232002.1|2891742_2893362_+|VWA-domain-containing-protein	gnl|CDD|225281	COG2425, COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only].	1.31614e-33
NZ_CP022310.1|WP_167530191.1|2879520_2881212_-|Ig-like-domain-repeat-protein	gnl|CDD|223893	COG0823, TolB, Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion].	0.0059102
NZ_CP022310.1|WP_142232006.1|2897850_2898420_-|ATP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	3.47618e-39
NZ_CP022310.1|WP_142231999.1|2887737_2888592_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.30902e-07
NZ_CP022310.1|WP_142193446.1|2876215_2877148_-|trypsin-like-peptidase-domain-containing-protein	gnl|CDD|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	4.20305e-07
NZ_CP022310.1|WP_142232005.1|2896674_2897808_-|FAD-dependent-oxidoreductase	gnl|CDD|235874	PRK06847, PRK06847, hypothetical protein; Provisional.	1.95143e-125
NZ_CP022310.1|WP_142231995.1|2884054_2884747_+|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	1.44391e-29
NZ_CP022310.1|WP_167530033.1|2885843_2887322_-|hypothetical-protein	gnl|CDD|214549	smart00191, Int_alpha, Integrin alpha (beta-propellor repeats). Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.	0.00114778
NZ_CP022310.1|WP_142231994.1|2883514_2884027_+|hypothetical-protein	gnl|CDD|379650	pfam14568, SUKH_6, SMI1-KNR4 cell-wall. Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.	0.0034919
NZ_CP022310.1|WP_142231996.1|2884734_2885628_-|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.33286e-22
NZ_CP022310.1|WP_142232000.1|2889384_2890356_+|SMI1/KNR4-family-protein	gnl|CDD|214864	smart00860, SMI1_KNR4, SMI1 / KNR4 family. Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.	0.00901433
NZ_CP022310.1|WP_142232004.1|2894856_2896419_+|solute-binding-protein	gnl|CDD|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	2.59095e-17
NZ_CP022310.1|WP_142232001.1|2890527_2891733_+|AAA-domain-containing-protein	gnl|CDD|184118	PRK13531, PRK13531, regulatory ATPase RavA; Provisional.	2.70718e-43
NZ_CP022310.1|WP_142193447.1|2877679_2878891_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_CP022310.1|WP_142231993.1|2881344_2882976_-|hypothetical-protein	gnl|CDD|128941	smart00701, PGRP, Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine.	1.49696e-45

Protein sequences

>NZ_CP022310.1|WP_167530033.1|2885843_2887322_-|hypothetical-protein
MRTRTLAVALAVASAAAGLSLTLAPTASAATSATDDFNGDGVADLVVATPNAPVDGHVNAGSVTVLYGSADGVAPARSTTLTQSSAGVPGDVRSHDLFGATHAAGDLDADGYTDLVVGTPGDSVPYSSSFGTVSVLWGGPSGLTGDGISLASPYATSEWSSEKDYGKKVVVADLDGDGVPQIATLSRTNLWVYDDLAGRTAPTDVRHFENYNAYVQPRTLTAADFTGTGGAQLVVTGPENCGTEGGCQFTGVYTWSDSGLQEVWLSDPGADATGANEAPTVSTAAGDIDGDGFADLVTGHVPASATTSGEYADAAGFVHVRYGSAQGLGAQRTGTLEAPGGSRSGDNFGASVAVGDVTGDGHADVAAGAPGATLRGVPGAGATVLLKGSATGLTDTGAQVFHQDTDGVPGTGAADDWFGSAVALTDVDGDGKADLTVAAKGEDTGDGTARDGADWVLRGTADGLTAVGTTSFGAASFGLTYPNAEFGSVLGG
>NZ_CP022310.1|WP_142231996.1|2884734_2885628_-|alpha/beta-fold-hydrolase
MTHLTTTVNAHGITLGIQSFGDEEAPLVLLVGGTTMLSWPDALCERLAAGGRRVVRYDLRDSGQSTTRDPEAPAYTLRDLAADAAALADALGGRPAHLAGIGVGGMVAQVAALDHPDAFSALTLVGTRSVAPGPTDDDLPDHDRATMGRLFTHAMPDWTDREAVADFAAAGAEILGDDPVAARAVAARIWDRTPGAAPAVRMANHLGMVFSRLDCTPRWRERLPEIKVPTLVVHGRRNRFFPVGNAEAIAREIPGARLLVLEDAATAIPDAAIDAVTGAMLTLGQRTPGHVPAPQEP
>NZ_CP022310.1|WP_142231995.1|2884054_2884747_+|signal-peptidase-I
MDRKRGAFVTSRRAGRGLRVAAWVLVPLGLVLLLGAAAGIVGTGVLDRERITVGGDAMRPTYRPGDRLTIERVDEAGIRRGDVVLVSVPGRYGGAPVLQRVIGLGGDHVESRDGAQVVVNGKRIDEPYVMRDELGTTGAPYDVTVPDGRLFLLGDNRPNANDSRYFLDEQSGSVAASGVRGRVPQEERAVSVAPLALGAFGAVLTLVGVGLGIGGFMAGRRTGYGYGYGS
>NZ_CP022310.1|WP_142231994.1|2883514_2884027_+|hypothetical-protein
MWVQRLIELTSWEPLRLSVDWESVEGELQAPLPADYKLLFETFGGGVFSESVYFFGPSGPPAFDFLTQWRASLSAGGDDDAYPVYSPGEKGVIVWAAAEWADEYAWLVDARNPGAYSVLVRGDVGEWRTYDMSTAEFLYRVLADEDFKPFGIAQCDLDPTFEPGRPVHGS
>NZ_CP022310.1|WP_142193451.1|2883142_2883382_-|hypothetical-protein
MAVQHPREQAKHRSRARRRNYGSSVWWPVKQADIQVHLKGEASSLRPFMSARSRGALPVVYNRPDARQLYAALTRVVES
>NZ_CP022310.1|WP_142231993.1|2881344_2882976_-|hypothetical-protein
MSPRGIRARRSRASQRTMWLAVGVAVLAGTGATAVSVTGGSGVTGADDTSRPARAHTLALDGKDPKKRELPRTDTQSFSLVGVSWEDGADDFEGTAQIRTRSADSGTWTDWRDLDFGIRAPETEEGDASAVRGASEPLWVGPSDAVEARVVAGGEETAVPDALRLDMIDPGDEKGGTGQDRSGGKGGSANGNGNGKGKPSAGPAAGESATASAPTVGGDAEPTTAPEQSAEPAPEPTDAPAAEQPTPSDDPTPSEQPTQEPTADAGAPAPSEEPASEPAGPSEEPTAPTPSPDPTQEPTEGPAGPAPSEEPTAEPTAAPATEPTTEPSAQPEPTGSASPSAPAAPAIVSRAEWGADESLVTDPPSYLDKVDAVFVHHTAGTNDYDCAESPAVIRAILTYHVQTNGWSDTGYNFFVDKCGTVFEGRAGGVDKPVRGAHTYGFNGYSSGVSLLGDYENGGTPTAAAQQAIADLSAWKLGLHGVDPEAKVTLTAAGDTGVYRTGEQATLDTISGHRDGYATLCPGATLYAALPEIRRTAGISMYAH
>NZ_CP022310.1|WP_167530191.1|2879520_2881212_-|Ig-like-domain-repeat-protein
MAAALTGGGLTVAAAPAAHAAASALVAKLPITSFSALTVDSAHQRVYVADSNLGYYDNKGLIAVYDFSGERITTLTTTRHISGLALNADGSVLYAGGREGILRYDTATYQPLASGTAGTDTCGRSMAFAGGKPYHTTTYANYMSDCDTTLTYLDNHQADNTWQRTGWQDSGKLQLEAGPGDRLLMGQPVNAKAGDPFLAVFDASGETLVRTAGRRFADSDGKGALNLKDMAFSPDGTKVAVADAAAGTRLLNTADLSDAGTAHPALPAGSAASAVAFSGDGKYLARGASASGSTPDLLLSPADPGDATAPLEFAFEGSLDGDRVAPRGLEWSADGSRLFAVTTNTAGNQYWLHVVQPPAAQYDARFTGGLTHGPAEAVAGEPLAVRGKLELDGPAPAEPPKVTATRTDANGTHELGTTAVRADGTFTVLDEPDLVGEATYTVSFLGDLTHRPATDVTHTVYVGKAASAIALTAPAQASMSTGVRITGTFTAHGKALPERATLTVQRTDRLGTGTLSSVTVAADGTFTVDDLPRTRRETTYTVSWPGDALHEGSTASATVDVTR
>NZ_CP022310.1|WP_142193448.1|2878967_2879390_+|hypothetical-protein
MYEPIRSKSVHSTMAGTSHDFPHRTREEELDIQLAGHLAALLAVTDELRAAAPTADLDAAAERLAEQVTRLRGGHAPARASVTTTGREPNAQALHRRAHTLAGRALVVAASRADTAAAILAAERMDAHTAALRPRELAPR
>NZ_CP022310.1|WP_142193447.1|2877679_2878891_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MQVIQSTKLANVCYEIRGPVLEEAMRLEAAGHRILKLNTGNPAAFGFECPPEILEDVLRNVSSAHGYGDAKGLLAARRAVVMHNQTLGIETDVEHVFIGNGVSELIVMAMQGLLDDGDEVLVPAPDYPLWTAAVSLSGGTAVHYRCDEQSDWMPDLADVERKVTDRTKAIVIINPNNPTGAVYDEAVVKGLTDIARRHNLLVCSDEIYDKILYDDARHVPTASVAPDLLTLTFNGMSKAYRVAGYRVGWMSISGPRAHADSYIEGLTILANMRLCANMPGQHGVVAALSGRQSINDLVLPGGRLREQRDVAYELLTQIPGVSCVKPKGALYLFPRLDPDVFKIKDDRRMVLDLLRREKIMVVQGTGFNWPEPDHFRVVTLPSVTDLRDAVGRIARFLDGYSQP
>NZ_CP022310.1|WP_142193446.1|2876215_2877148_-|trypsin-like-peptidase-domain-containing-protein
MRKPLVVALCALAFAGAGAAPAVAAAPSPTGADTTTGAGPTTLMDVVNSTVGTAADTLNGLTAPKEGAVNFAGTVSLSNCSGSVVRMPDSAADDPALVLTNGHCLESGFPAPGQVVVDQASSRTFGLLNSSGSKVATLRADRLLYATMTDTDAAVYRLGTTYAQIKSAYGIDPLTLADSHPQAGTAISVVSGYWKRIYSCSVDGFVYRMKEGDWTWKDSVRYTSECNTIGGTSGSPVVDDATRTVVAVNNTGNEDGERCTVNNPCEVDESGNVTVRQGINYAQQTYQFPACFGVDNKLELSASGCVLPKP
>NZ_CP022310.1|WP_142231999.1|2887737_2888592_-|helix-turn-helix-domain-containing-protein
MGQRKDIDGSTSVPTFYGSELRWKREEAGLTLQQLVEGSFYGPSHLSEIERGTRRMPAELAEHVDKVLGTDGFFRRRCEDVRRAKRRGHASYFERVLEAEKHAETIEEWCPTLIPGLLQTDAYAREVTRSAHPLAPEEEVEEKVSARLARFRLFEDNHKTPEYWVVLPELLLRQPILSPEQSAEQWDRIAELVRRHRIVAQILPWNCGPHPLMLGTAMVMTFPDAPPLVYTESQYSGDTIEDPALVKQYHKAYDRLRAAALPPEASLALIEQAAEEGRNGKQGD
>NZ_CP022310.1|WP_142193458.1|2888761_2888971_+|hypothetical-protein
MHDHSPEAADACVEELRAALAAHGIRLPSLGVDVPTFASRYPARPLIALGNCNLLTARALTAALRRDGA
>NZ_CP022310.1|WP_142193459.1|2888970_2889384_+|ATP-binding-protein
MRAPLTLGLLATPAAVAGVRRALADYGTDVQLCASELVTNVVVHLGEGVPVTVRVFRDGGRTRLEVTDPDPCALPVRRPAVGADEESGRGLALLDALALDWGVTQGSGEKTVWCELVAEPPEGRVLPGRGAMSVASV
>NZ_CP022310.1|WP_142232000.1|2889384_2890356_+|SMI1/KNR4-family-protein
MAAMDVVEELLSSIHRLTAQRAGTPVCGRHGQAPGHVCLVPTAETGLAEIGLAELEEAIGSRFGEPRSLARRGAVDPAVSARTGLPLLAPFGERTVEMRAWAYGDRWIGCGTARDDDGDGDVRVVVLVAERPGPAEGPAEPASWVDRIVAVTGWDTTRTRTVDWAAVEDRLGTRLPGDYKRLVEIFGGSGAFDGYLQLHVPDAYDRSTDIVRHTEWLAEWTRARGSRLWEPYPVYPAAGGVLQWASTEQADGFYWLTGDPDPDTWPVLAQEEIPDSWQRSEATTGEFLYRLLTDPDHPFSTARHFDVHWFQSYGADEPPAEGN
>NZ_CP022310.1|WP_142232001.1|2890527_2891733_+|AAA-domain-containing-protein
MSGAPDARDTARRLRAIRDELSERFYERADVVRTLVVALLAGQHSLVLGPPGTAKSELARELTGRIEGAAYWEILLSKFTAPTRMFGPIDVAALARGEYRQVYDGRATTAHVAFIDEIFKCSTAALNETLGYLNERIYHPENGGAPIRCPLIAAITASNELPSGEDSAAIYDRLLVRIEVGYLEDPSNFAALVRSAVGRPAAPAPPTTVELAALQHAVTGAVPAVDVPDTIVDAMVTLRAALRRKELVASDRRWRQAVRLLQASAYLDGRTAVTETDLSVLTHVLWDSPAERPVVEREVLHLVNPDAKEALDLADVIDELEAQLDAMAGQSREALSEWVIKKAHNQLAMAGKRLEKLREEAAGAGRSTAAIDRVTGRQRAVRARVLTEALGMDASMVQAQL
>NZ_CP022310.1|WP_142232002.1|2891742_2893362_+|VWA-domain-containing-protein
MGEQRSSIDVLAVRSGPWLARTATAAERNTTAVVAGPFDRVVWREVYEQSAGLRELAAELGSRHAHTDDLLTDVFLAAYQAAPRLREATAMAPSRLVNHQVVTSLVRSPDFAGLHRETAGDAYAAALAVLAQSSVLRGLLERSRDARDRAGQAEAARQNAVAAATAVSEAVRRAADEAGTDGTVPAPAADAVRRAIQAAEAAEATARQETRAAAQALAAALPGIRAAARNATASAAEAVRQEAALMRAWGVGAGELERMPFDERARLAERLRSGRLARWAELIGRFRQMAGGERARKVENATGELVGVTLGDDLSRVVPSELAVLGLPALRAVFAARYAAGELMLYDSRGEQTTGQGAVIACVDTSHSMYAEGPGGITREAWSKACALALLDQARHAGRDFVGILFSAADKIRVFRFPGDRPAGVTEVLDFVETFLGGGTDFQRPLGTAAALLEEEFDDTARRRGDIVLITDDACEVTEQWVRGWNDAKRRLGFRLFGVAITGPDATGTGSVLEALCDNLRTIDDLTDVHATADLFRVI
>NZ_CP022310.1|WP_142232003.1|2893469_2894546_+|hypothetical-protein
MRRIVGIVLAVLLIGGVAAAVVAGRDSEETGTATKTVRMVIGSEKAAFFADPDVVEALAAQGYTVEAETSGSWAMEGLDLDGYDLAFPSSRAPAAELAQKHGVRGILPRPFYSPLVVVSRRGAAEVLAANGLATPAGRTPGTLKMAAYLDAARRDRTWQQLKGAERYGELTGTLFISSTDPQTSNSGALYLAAASYVANGGKVVASDAEVERTAPLMRTLVSVQGAQQSSTDAAFRDFVSGAGNPLVLVYESQVAALLDEQQNADDLVVLYPDTTVNSDHTVVPLTDDGRELAELLGSDPTLRKLAVRHGFRPQGAITEFTAATVGRTAYLKQQLTGVRQAPVPTSAVLRELARRARG
>NZ_CP022310.1|WP_142232004.1|2894856_2896419_+|solute-binding-protein
MRRPSPAAARRHLAVLLAAGALLTACTSGAEPREDTDPHTAEPGTLRVLASSELSDMTPVFERIEKDTGVTLRPTYIGTLDAVDILATGKADGRYDAVWLSSNDYLRLRPAAADKVVSETPVMSSPVAIGVKTATVERLGWKPEEVTWSAVEKAVRDGRLTYGMTDPARSNSGFSTLVAVASALSGAQSALTDADVAKAGPRMEEFFRGQRLTSGSSGWLASAFARRGDVDALLNYESVLEGFKNLTVIRPKDGVVTADYPLSSLAATGPATREDVRRVAEALRTDAVQRLITEHTHRRPVVASVPPAAGLDPSRRRELPFPGSRSVADGLLDAYENELRRPSRTVYVLDTSGSMEGERLSRLKQALTRLTSDFRDREEVTLMPFGSAVKSVRTHVVRPEDPETGLSAIRADTARLRAEGETAIYTSLRTAYDHFRDDRDTFTSIVLMTDGENTAGDDADGFASFHRGLTGERRDIPVFPILFGDSDRTELEHIAELTGGRLFDGRGSLDGAFDEIRGYQ
>NZ_CP022310.1|WP_142232005.1|2896674_2897808_-|FAD-dependent-oxidoreductase
MASRLRVLVHGGGIGGLTLATALARRGHTVEVAELRGELEALGVGIIQPSNALHVMREIGVLDDCLAAGFAWEVLTIADPAGNTLARIPQPRMGDAPATNGIPRPALARVLGAAATAAGAKIRFSATVTDLTDDGAGVDVALSDGSSGRWDLVVGFDGIGSPLRSRLYGDRFTPEYTGFANWRVTLPRLPEVRGVVMATAGHAAKALLTPITPDSMYLGAVFAEDPDFRPDPERAHEQLAGRLTMFSGPIAEALASATDPAAVVYSRISQVTVDAPWHVGRVALAGDAAHASAPQLAQGAAMAVEDAIVLAESLDAYDGVPAALAAWEERRRPRALWVQALSRAVLKQETGGETTPEEDELLKIGVPGAAQVLVQPY
>NZ_CP022310.1|WP_142232006.1|2897850_2898420_-|ATP-binding-protein
MNTSQAAPAALKILVAGGFGVGKTTLVGAVSEVAPLHTEEYMTRASVGVDDLAGVGEKETTTVALDFGRITINSDLVVYLFGTPGQERFWFMWNDLVHGALGGVVIADTRRLDSSFASIDFFESRRIPFVVAINCFHGRNTRTADEIRTALDLDPYVPLLIGDVRERSYGKETLLALVDHLDRLNAPAA

Crispr_ID: NZ_CP022310_4

• CRISPR_ID: NZ_CP022310_4
• CRISPR_location: 2899680-2899995
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP022310_4

Consensus_repeat	Method
GGGNCGTNCCGTACGGGGTGTCGGTCGT	CRT

spacers of NZ_CP022310_4

>4.1|2899708|41|NZ_CP022310|CRT
GCGCGTTCCGTACGAGGCTTCGCCGGTGTCCGGGGCGGACC
>4.2|2899777|47|NZ_CP022310|CRT
TTCGGGGGTGTACGGGGCCGGTTGGTACGAGGTTTCGGGGGGCGGCT
>4.3|2899852|41|NZ_CP022310|CRT
GCGCGTTCCGTAGGGGGCTTCGCCGGTGTCCGGGGCGGACC
>4.4|2899921|47|NZ_CP022310|CRT
TTCCGGGGTGTGCGGGGCCGGCTCGTACGGGGTGTCGGGGGTCGGCT

CRISPR arrays and Neighbor proteins around NZ_CP022310_4

CRISPR arrays

The CRISPR arrays of NZ_CP022310_4

>merge|NZ_CP022310|4|2899680-2899995|CRT
GGGTCGTCCCGTACGGGGTGTCGGTCGTGCGCGTTCCGTACGAGGCTTCGCCGGTGTCCGGGGCGGACCGGGTCGTCCCGTACGGGGTGTCGGTCGTTTCGGGGGTGTACGGGGCCGGTTGGTACGAGGTTTCGGGGGGCGGCTGGGGCGTTCCGTACGGGGTGTCGGTCGTGCGCGTTCCGTAGGGGGCTTCGCCGGTGTCCGGGGCGGACCGGGTCGTCCCGTACGGGGTGTCGGTCGTTTCCGGGGTGTGCGGGGCCGGCTCGTACGGGGTGTCGGGGGTCGGCTGGGGCGTTCCGTACGGGGTGGGGTGGCC

>NZ_CP022310|4|1|2899680-2899995|CRT
GGGTCGTCCCGTACGGGGTGTCGGTCGT	GCGCGTTCCGTACGAGGCTTCGCCGGTGTCCGGGGCGGACC
GGGTCGTCCCGTACGGGGTGTCGGTCGT	TTCGGGGGTGTACGGGGCCGGTTGGTACGAGGTTTCGGGGGGCGGCT
GGGGCGTTCCGTACGGGGTGTCGGTCGT	GCGCGTTCCGTAGGGGGCTTCGCCGGTGTCCGGGGCGGACC
GGGTCGTCCCGTACGGGGTGTCGGTCGT	TTCCGGGGTGTGCGGGGCCGGCTCGTACGGGGTGTCGGGGGTCGGCT
GGGGCGTTCCGTACGGGGTGGGGTGGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_167530034.1|2907478_2909512_-|DUF255-domain-containing-protein	unknown	unknown	gnl|CDD|224250
NZ_CP022310.1|WP_142193467.1|2898895_2899333_-|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl|CDD|367422
NZ_CP022310.1|WP_142193459.1|2888970_2889384_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NZ_CP022310.1|WP_142232008.1|2905779_2906457_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
NZ_CP022310.1|WP_142193500.1|2898425_2898782_-|DUF742-domain-containing-protein	unknown	unknown	gnl|CDD|283084
NZ_CP022310.1|WP_167530035.1|2910474_2911467_-|translation-initiation-factor-2	unknown	unknown	unknown
NZ_CP022310.1|WP_142232002.1|2891742_2893362_+|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|225281
NZ_CP022310.1|WP_142232009.1|2906470_2907208_+|hypothetical-protein	unknown	unknown	gnl|CDD|376668
NZ_CP022310.1|WP_142193469.1|2905010_2905724_+|hemolysin-III-family-protein	unknown	unknown	gnl|CDD|367292
NZ_CP022310.1|WP_142232005.1|2896674_2897808_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235874
NZ_CP022310.1|WP_142232006.1|2897850_2898420_-|ATP-binding-protein	unknown	unknown	gnl|CDD|225138
NZ_CP022310.1|WP_142232010.1|2911527_2916015_+|peptidase-C14-caspase-catalytic-subunit-p20	unknown	unknown	gnl|CDD|368582
NZ_CP022310.1|WP_142234101.1|2918210_2920172_+|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|379274
NZ_CP022310.1|WP_142232003.1|2893469_2894546_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_167530192.1|2909685_2910330_+|acetyltransferase	unknown	unknown	gnl|CDD|274656
NZ_CP022310.1|WP_142232000.1|2889384_2890356_+|SMI1/KNR4-family-protein	unknown	unknown	gnl|CDD|214864
NZ_CP022310.1|WP_142232004.1|2894856_2896419_+|solute-binding-protein	unknown	unknown	gnl|CDD|238119
NZ_CP022310.1|WP_142232001.1|2890527_2891733_+|AAA-domain-containing-protein	unknown	unknown	gnl|CDD|184118
NZ_CP022310.1|WP_142232007.1|2902850_2904671_-|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl|CDD|235256
NZ_CP022310.1|WP_142232011.1|2916729_2918130_+|hypothetical-protein	unknown	unknown	gnl|CDD|376727

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_167530034.1|2907478_2909512_-|DUF255-domain-containing-protein	gnl|CDD|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP022310.1|WP_142193467.1|2898895_2899333_-|roadblock/LC7-domain-containing-protein	gnl|CDD|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	2.46017e-19
NZ_CP022310.1|WP_142193459.1|2888970_2889384_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.39759e-16
NZ_CP022310.1|WP_142232008.1|2905779_2906457_+|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	1.03067e-18
NZ_CP022310.1|WP_142193500.1|2898425_2898782_-|DUF742-domain-containing-protein	gnl|CDD|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	3.50707e-26
NZ_CP022310.1|WP_142232002.1|2891742_2893362_+|VWA-domain-containing-protein	gnl|CDD|225281	COG2425, COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only].	1.31614e-33
NZ_CP022310.1|WP_142232009.1|2906470_2907208_+|hypothetical-protein	gnl|CDD|376668	pfam01927, Mut7-C, Mut7-C RNAse domain. RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C-terminus.	7.3436e-58
NZ_CP022310.1|WP_142193469.1|2905010_2905724_+|hemolysin-III-family-protein	gnl|CDD|367292	pfam03006, HlyIII, Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.	9.5672e-51
NZ_CP022310.1|WP_142232005.1|2896674_2897808_-|FAD-dependent-oxidoreductase	gnl|CDD|235874	PRK06847, PRK06847, hypothetical protein; Provisional.	1.95143e-125
NZ_CP022310.1|WP_142232006.1|2897850_2898420_-|ATP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	3.47618e-39
NZ_CP022310.1|WP_142232010.1|2911527_2916015_+|peptidase-C14-caspase-catalytic-subunit-p20	gnl|CDD|368582	pfam05729, NACHT, NACHT domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.	0.00078345
NZ_CP022310.1|WP_142234101.1|2918210_2920172_+|pentapeptide-repeat-containing-protein	gnl|CDD|379274	pfam13576, Pentapeptide_3, Pentapeptide repeats (9 copies).	1.6591e-09
NZ_CP022310.1|WP_167530192.1|2909685_2910330_+|acetyltransferase	gnl|CDD|274656	TIGR03570, NeuD_NnaD, sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family. This family of proteins includes the characterized NeuD sialic acid O-acetyltransferase enzymes from E. coli and Streptococcus agalactiae (group B strep). These two are quite closely related to one another, so extension of this annotation to other members of the family in unsupported without additional independent evidence. The neuD gene is often observed in close proximity to the neuABC genes for the biosynthesis of CMP-N-acetylneuraminic acid (CMP-sialic acid), and NeuD sequences from these organisms were used to construct the seed for this model. Nevertheless, there are numerous instances of sequences identified by this model which are observed in a different genomic context (although almost universally in exopolysaccharide biosynthesis-related loci), as well as in genomes for which the biosynthesis of sialic acid (SA) is undemonstrated. Even in the cases where the association with SA biosynthesis is strong, it is unclear in the literature whether the biological substrate is SA iteself, CMP-SA, or a polymer containing SA. Similarly, it is unclear to what extent the enzyme has a preference for acetylation at the 7, 8 or 9 positions. In the absence of evidence of association with SA, members of this family may be involved with the acetylation of differring sugar substrates, or possibly the delivery of alternative acyl groups. The closest related sequences to this family (and those used to root the phylogenetic tree constructed to create this model) are believed to be succinyltransferases involved in lysine biosynthesis. These proteins contain repeats of the bacterial transferase hexapeptide (pfam00132), although often these do not register above the trusted cutoff.	1.27269e-50
NZ_CP022310.1|WP_142232000.1|2889384_2890356_+|SMI1/KNR4-family-protein	gnl|CDD|214864	smart00860, SMI1_KNR4, SMI1 / KNR4 family. Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.	0.00901433
NZ_CP022310.1|WP_142232004.1|2894856_2896419_+|solute-binding-protein	gnl|CDD|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	2.59095e-17
NZ_CP022310.1|WP_142232001.1|2890527_2891733_+|AAA-domain-containing-protein	gnl|CDD|184118	PRK13531, PRK13531, regulatory ATPase RavA; Provisional.	2.70718e-43
NZ_CP022310.1|WP_142232007.1|2902850_2904671_-|phosphoenolpyruvate-carboxykinase-(GTP)	gnl|CDD|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP022310.1|WP_142232011.1|2916729_2918130_+|hypothetical-protein	gnl|CDD|376727	pfam02089, Palm_thioest, Palmitoyl protein thioesterase.	9.936e-06

Protein sequences

>NZ_CP022310.1|WP_142193467.1|2898895_2899333_-|roadblock/LC7-domain-containing-protein
MTRSTATHQDLDWLLDGLVDSVAETRNAVLLSDDGLVVSHSQSIARADAERLAAICTGQQSLARGVGQLFDGGVVHQVIVELADLWLFIIAAGQGTHLAVVASQEVDAEVMSLAMHNLVQQVGQKLGTPARSGFDAFGTGQGSGA
>NZ_CP022310.1|WP_142193500.1|2898425_2898782_-|DUF742-domain-containing-protein
MVRPYTITRGRTAPARDDLTLITVLTTVEDPRDEHGAPVRPGRLQPEHRRILERCRRPAAVAEVAADLDLAVSVTKILLADLVGQGLLAARAPITVAWAAGGVDPSLLAAVRDGLRRL
>NZ_CP022310.1|WP_142232006.1|2897850_2898420_-|ATP-binding-protein
MNTSQAAPAALKILVAGGFGVGKTTLVGAVSEVAPLHTEEYMTRASVGVDDLAGVGEKETTTVALDFGRITINSDLVVYLFGTPGQERFWFMWNDLVHGALGGVVIADTRRLDSSFASIDFFESRRIPFVVAINCFHGRNTRTADEIRTALDLDPYVPLLIGDVRERSYGKETLLALVDHLDRLNAPAA
>NZ_CP022310.1|WP_142232005.1|2896674_2897808_-|FAD-dependent-oxidoreductase
MASRLRVLVHGGGIGGLTLATALARRGHTVEVAELRGELEALGVGIIQPSNALHVMREIGVLDDCLAAGFAWEVLTIADPAGNTLARIPQPRMGDAPATNGIPRPALARVLGAAATAAGAKIRFSATVTDLTDDGAGVDVALSDGSSGRWDLVVGFDGIGSPLRSRLYGDRFTPEYTGFANWRVTLPRLPEVRGVVMATAGHAAKALLTPITPDSMYLGAVFAEDPDFRPDPERAHEQLAGRLTMFSGPIAEALASATDPAAVVYSRISQVTVDAPWHVGRVALAGDAAHASAPQLAQGAAMAVEDAIVLAESLDAYDGVPAALAAWEERRRPRALWVQALSRAVLKQETGGETTPEEDELLKIGVPGAAQVLVQPY
>NZ_CP022310.1|WP_142232004.1|2894856_2896419_+|solute-binding-protein
MRRPSPAAARRHLAVLLAAGALLTACTSGAEPREDTDPHTAEPGTLRVLASSELSDMTPVFERIEKDTGVTLRPTYIGTLDAVDILATGKADGRYDAVWLSSNDYLRLRPAAADKVVSETPVMSSPVAIGVKTATVERLGWKPEEVTWSAVEKAVRDGRLTYGMTDPARSNSGFSTLVAVASALSGAQSALTDADVAKAGPRMEEFFRGQRLTSGSSGWLASAFARRGDVDALLNYESVLEGFKNLTVIRPKDGVVTADYPLSSLAATGPATREDVRRVAEALRTDAVQRLITEHTHRRPVVASVPPAAGLDPSRRRELPFPGSRSVADGLLDAYENELRRPSRTVYVLDTSGSMEGERLSRLKQALTRLTSDFRDREEVTLMPFGSAVKSVRTHVVRPEDPETGLSAIRADTARLRAEGETAIYTSLRTAYDHFRDDRDTFTSIVLMTDGENTAGDDADGFASFHRGLTGERRDIPVFPILFGDSDRTELEHIAELTGGRLFDGRGSLDGAFDEIRGYQ
>NZ_CP022310.1|WP_142232003.1|2893469_2894546_+|hypothetical-protein
MRRIVGIVLAVLLIGGVAAAVVAGRDSEETGTATKTVRMVIGSEKAAFFADPDVVEALAAQGYTVEAETSGSWAMEGLDLDGYDLAFPSSRAPAAELAQKHGVRGILPRPFYSPLVVVSRRGAAEVLAANGLATPAGRTPGTLKMAAYLDAARRDRTWQQLKGAERYGELTGTLFISSTDPQTSNSGALYLAAASYVANGGKVVASDAEVERTAPLMRTLVSVQGAQQSSTDAAFRDFVSGAGNPLVLVYESQVAALLDEQQNADDLVVLYPDTTVNSDHTVVPLTDDGRELAELLGSDPTLRKLAVRHGFRPQGAITEFTAATVGRTAYLKQQLTGVRQAPVPTSAVLRELARRARG
>NZ_CP022310.1|WP_142232002.1|2891742_2893362_+|VWA-domain-containing-protein
MGEQRSSIDVLAVRSGPWLARTATAAERNTTAVVAGPFDRVVWREVYEQSAGLRELAAELGSRHAHTDDLLTDVFLAAYQAAPRLREATAMAPSRLVNHQVVTSLVRSPDFAGLHRETAGDAYAAALAVLAQSSVLRGLLERSRDARDRAGQAEAARQNAVAAATAVSEAVRRAADEAGTDGTVPAPAADAVRRAIQAAEAAEATARQETRAAAQALAAALPGIRAAARNATASAAEAVRQEAALMRAWGVGAGELERMPFDERARLAERLRSGRLARWAELIGRFRQMAGGERARKVENATGELVGVTLGDDLSRVVPSELAVLGLPALRAVFAARYAAGELMLYDSRGEQTTGQGAVIACVDTSHSMYAEGPGGITREAWSKACALALLDQARHAGRDFVGILFSAADKIRVFRFPGDRPAGVTEVLDFVETFLGGGTDFQRPLGTAAALLEEEFDDTARRRGDIVLITDDACEVTEQWVRGWNDAKRRLGFRLFGVAITGPDATGTGSVLEALCDNLRTIDDLTDVHATADLFRVI
>NZ_CP022310.1|WP_142232001.1|2890527_2891733_+|AAA-domain-containing-protein
MSGAPDARDTARRLRAIRDELSERFYERADVVRTLVVALLAGQHSLVLGPPGTAKSELARELTGRIEGAAYWEILLSKFTAPTRMFGPIDVAALARGEYRQVYDGRATTAHVAFIDEIFKCSTAALNETLGYLNERIYHPENGGAPIRCPLIAAITASNELPSGEDSAAIYDRLLVRIEVGYLEDPSNFAALVRSAVGRPAAPAPPTTVELAALQHAVTGAVPAVDVPDTIVDAMVTLRAALRRKELVASDRRWRQAVRLLQASAYLDGRTAVTETDLSVLTHVLWDSPAERPVVEREVLHLVNPDAKEALDLADVIDELEAQLDAMAGQSREALSEWVIKKAHNQLAMAGKRLEKLREEAAGAGRSTAAIDRVTGRQRAVRARVLTEALGMDASMVQAQL
>NZ_CP022310.1|WP_142232000.1|2889384_2890356_+|SMI1/KNR4-family-protein
MAAMDVVEELLSSIHRLTAQRAGTPVCGRHGQAPGHVCLVPTAETGLAEIGLAELEEAIGSRFGEPRSLARRGAVDPAVSARTGLPLLAPFGERTVEMRAWAYGDRWIGCGTARDDDGDGDVRVVVLVAERPGPAEGPAEPASWVDRIVAVTGWDTTRTRTVDWAAVEDRLGTRLPGDYKRLVEIFGGSGAFDGYLQLHVPDAYDRSTDIVRHTEWLAEWTRARGSRLWEPYPVYPAAGGVLQWASTEQADGFYWLTGDPDPDTWPVLAQEEIPDSWQRSEATTGEFLYRLLTDPDHPFSTARHFDVHWFQSYGADEPPAEGN
>NZ_CP022310.1|WP_142193459.1|2888970_2889384_+|ATP-binding-protein
MRAPLTLGLLATPAAVAGVRRALADYGTDVQLCASELVTNVVVHLGEGVPVTVRVFRDGGRTRLEVTDPDPCALPVRRPAVGADEESGRGLALLDALALDWGVTQGSGEKTVWCELVAEPPEGRVLPGRGAMSVASV
>NZ_CP022310.1|WP_142232007.1|2902850_2904671_-|phosphoenolpyruvate-carboxykinase-(GTP)
MARDIAEPGVPTTHQGLISWVNEIAELTQPDNVVWCDGSEAEYERLCEELVAKGTFRKLDPIKRPNSYYAASDPTDVARVEDRTFICSEKEEDAGPTNHWKAPAEMREIFRGEQGVFRGSMKGRTMYVVPFCMGPLGSPLSAIGVEITDSAYVAVSMRTMTRMGRPVLDELGSDGFFVKAVHSVGAPLEPGQQDVPWPCNSTKYISHFPEDREIWSYGSGYGGNALLGKKCYALRIASVMARDEGWLAEHMLVLKLTPPTGEPKYVAAAFPSACGKTNLAMLEPTISGWTVETIGDDIAWMRFGEDGRLYAINPEAGFFGVAPGTGEHTNANAMKTLWGNSVFTNVALTDDGDVWWEGMTEEVPAHLTDWKGNDWTPESGTPAAHPNARFTTPAAQCPIIAPEWEDPKGVPISAILFGGRRASAVPLVTESFDWNHGVFLGANVASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYMAHWIDVAKDKDQSKLPKIYYVNWFRKDDEGRFVWPGFGENARVLKWIVERLEGRAEGVETPIGVLPAKGSLDTDGLDLSDADLDFLLTVDKDVWREEAALVPEHLNTFGDHTPKELWDQYHALVKRLG
>NZ_CP022310.1|WP_142193469.1|2905010_2905724_+|hemolysin-III-family-protein
MTALVPDASTEPPAEGRGPVETSLPHPVKPKLRGWLHLGMFPAALVAGLVLTAFADSPRGRLACAVYALTACLLFGVSALYHRGNWSPRMDGVLRRLDHANIFLIIAGTYTPLTILLLPHSKGRWLLWGIWAAAAAGIVFRVFWVGAPRWLYTPCYIAMGWAAVFFLPDFLRTGGIAVLVLVVVGGLLYSAGGVIYGIKKPNPSPRWFGFHEVFHSFTLAAFVAHYVGISLVAYQHA
>NZ_CP022310.1|WP_142232008.1|2905779_2906457_+|TetR-family-transcriptional-regulator
MKAARPPQAPARPPRPGLRERKKTKTREAIREAAFALIADQGYEATTIEQIAGRAEVSPSTVSRYFPAKEDIVLGDGYDRPLLAELSARPADEPWPASVRHVLRTAVGRALAEQPDRTALRARLMLEVPAVRSRMLESMAAVGRVLGETVAARTGLEADGLEVRVCTAALTAGLLETTRYWAEHGHGDDLTALVDRTLDVLEHGLPAPARPAGPAGNPPVGTTPA
>NZ_CP022310.1|WP_142232009.1|2906470_2907208_+|hypothetical-protein
MNGPEIHLEFAPELLLFVPRARPTGRTKAATDGVSSLGHVVESLGVPLTEVGALLVDGREVSAGHVPAAGESVTVRAVAHPQRVPGAPLRFLLDVHLGTLARRLRLLGVDTAYESTDIGDPALAARSAAERRVMLSRDRGLLRRRELWAGAFVYSTRPEEQLGYVLDRFRPELRPWTRCTACNGLLRRVTKDDVADQLKGGTHRTYDVFAQCSACGRAYWKGAHHEQLEAIVQRAVAGTGRDGRP
>NZ_CP022310.1|WP_167530034.1|2907478_2909512_-|DUF255-domain-containing-protein
MPNRLAHETSPYLLQHADNPVDWWPWSEEAFAEARRRQVPVLLSVGYSSCHWCHVMAHESFEDPATAEELNAHFVSVKVDREERPDVDAVYMEAVQAATGQGGWPMTVFLTPDAEPFYFGTYFPPAPRHGMPSFRQVLQGVHQAWSERRGEVDEVAGKITRDLAGREIAYGDDQVPGEEQLAQALLGLTREYDPQRGGFGGAPKFPPSMVIEFLLRHHARTGAEGALQMARDTCERMARGGIYDQLGGGFARYSVDRDWVVPHFEKMLYDNALLCRVYTHLWRATGSGLARRVALETADFMVRELRTPEGAFASALDADSDDGSGRHVEGAYYVWTPAQLREVLGEADAELAARYFGVTEEGTFEEGASVLQLPQRDEVFDADRIDAVRQRLLAARAGRPAPGRDDKVVAAWNGLAIAALAETGACFDRPDLVEAAVAAGDLLVRLHMDDQARIARTSKDGHVGANAGVLEDYADVAEGFLALASVTGEGVWLEFAGLLLDHVLARFADPESGALYDTASDAERLIRRPQDPTDNAAPSGWTAAAGALLGYAAHTGSEPHRTAAERALGVVKALGPRVPRFIGWGLAVAEAVLDGPREVAVVGPSLDDPATAALHRTALLGTAPGAVVAAGTAGSDEFPLLDGRGLVGGEPAAYVCRNFTCDAPTTDPDRLRTALSG
>NZ_CP022310.1|WP_167530192.1|2909685_2910330_+|acetyltransferase
MVIGAGGMGRAIASLCARETDAAGRPVWNVLGFVDEDPRLHGAAVDGLPVLGGLPVVARHPGARLVVSICHVDFHGARRRIVETLGLPAHRYATIVHPTAVIDPSCTVGPGAVVMPQVCALPGGTVGAHAVVRPQTMMAADVTVRDYATVAAQVFLGRGVVVEEEAYVGAGTKVRERAVVGPRAVVGMGSLVLGPVPGHEVWAGSPLRRLGPAV
>NZ_CP022310.1|WP_167530035.1|2910474_2911467_-|translation-initiation-factor-2
MRRDRFTVVGRETGCHIFEGDGTRPVLEEEMRVKYRPRRVEFPEEIAGWRHAIQEEERRKEALGLPHRWNNQRFAVERVVVTRTHLAEEPVVTLTLQDADYYDFLTTSLNLERKQSNGLTLRQQYLEGEDPAHAPAWMNCSFGVNVALETGRDGRMLFSRRSAHVAGPNSSRWNSSANEGLARRHDLPEDGSPVSLYAVARRALYEELAVHATDTLDLEMLGFGLDLDNHQWAGFFRAVLPDLDEETLRLRWSRGVTDKWEHDRFEFVPADPESVLGFIADQPPELWTPCAPALFYLALVRGAVRAAGGDPAARFQVEAAEQRVIEARRP
>NZ_CP022310.1|WP_142232010.1|2911527_2916015_+|peptidase-C14-caspase-catalytic-subunit-p20
MIRSRMGDHLALVKSERRSSSLVGSVAVADYAHPDEDRRQQLRLRNVTAVRDRFTRIARSSLGFGESIRVDGAGAGRRNLWDGLENFLAHGARRKILYWTGHGVQHGDRGYYLACADSWQDGAFDPERALALTDLVDRLLRPECESDTLLVVDACSSHGHHLTTALGHALHLERTSVDRARRTRRAGFVVVGTSGFEAEVPEGRWVQWLEEALAKPDFVAPDHARPFEPSALYLPLPYLLDGVDAAAAASGLDEPAQRPSRTEVRSLPNSFLDNPYFQDGERRVYTPAVLTGREPWSAAGQFDLEEGSHLSRHFAGRQRALGRVVRWMDTHPNGLLAVTGLAGTGKTALLGRLALTSLPEWRETLGPGVDPSALPRLGTVHAALSCRGQSVHSLITALWGVLSSFDGMDPLPAGPVTPEQCRTAVDGLVSRAGSLNLLFDALDEALPDQAHDIARHLLNPLSGLRGVRVVVGTRPQPRRRTAAPAEEESLLDTLDQSVDPVVLGDDEDARRSIEAMALSVLGAEGSPYHGRARDADREWTARLIASGSRGSFLVARLAATELARRQRPGTEADLTEWMRSGGMDLRKRLTEEVDHLTSQQGAERAHEVLRPLAVVQGRGLPPGRTWLALANALRDPDSPELTSGDVQFVCRSANGGIVASQSAAHDEDITYHLAHPSYGEFFLTGAGLSARAAHRKVVAVLRAQSRAGWAGADPYPLDYLGAHAAQVGPEELTALFRDVDFLLCTNPDVMLPPASALARDCDGAALYGRVGGSFRNASSPLARKALLRATAFVSHREATYRALTGDGFLPWQEYWTDMPPDPLEWRRAAPLGGARTLSWRAGTGAAEAVLGDTLTAGGRGEILVLNPESGKRLLTRRTREASGEHGGALTEVREVGSGPHWTTVARDDRAVYFWRAGSRMPDHVYRWGGAVGALAAAERASETVVLAADGQRLWMWSWKGGMRGRGTHLTDIRMTDAERLAALPMGPRLFALVAGDRAELLEVDRGTRGSGGLLPEGIHLADLQAPALAAAATSAPVRDGGRLRGWIAAADGSRVWIWRCETDDAAPVAPPAVHLVRQLDSPARGLVFGRHGDELLLAGYEAVTVRVWSVEDPGREAAFQMTAPRDRAMAFEPGGQGLLAMADGPDIRVIDVAPALAARHGTRRRPSDQRPAVALAGAPDGPPLLCRTWGDRVRVSRPEPGAPADAPVVELVHVTQVTTVDAVRVADAWIVVAAAGRTVRLWRLREDLSVEARHDLALGRDAGEQVPSLGVAVDRTAGRLRVHVPDGGRVVHAELPVDASTGWRAGTPTPAGPSCCGVAARGMRDGTAWLAADLGDELLLWQDTEEPARNRHRHRVDDVRAAHLALGELYDPEDEESFPLLAWVDGGVFVKDLSAGDAKPARRLPGEFTGVTSLVFAGPAERPVLLVCDSWTAPRVWDVRGRTWLHGEGVPWRGYAVHAAAAAPDPQGVVVALQGNDRCDLIRLPHTFFEPGADG
>NZ_CP022310.1|WP_142232011.1|2916729_2918130_+|hypothetical-protein
MEHDLVVFVPGFLGSRLTRNGRDVWAECSDALLRSRPSARALADVALPPGLGDEPPEDRFRLTADALTTEPDSMPGLLSCMGYSGIRAALGDPVDGQYVPFAHDWRLSHRLLAEELRARVQRELDRWSEQVDAYYPDRPDDPKVLLVCHSTGGLIGRHYLECLGGRTTARALVTLGTPHQGVARAARLLAGNAVADGGGPEASALNAVLRELALTLPSVGQLLPVVEDAVRVAGRSRPRALTDRRYPVPGLPAGLVEDAFAFHREFSQAREAHRRTDAGGRLPYEVYCMASTARPTVRGIGLSADGLHLEDGGDGLLGPGDGTVPRESAVPEWTLPDRVEVLWTGVPHGAMATAAALGERLAAIRKGLPVTGMLAGHDHITLHTPSEAVAGRPFVAQVLGVNLHARRPRAVMRRVGARTREEIAFAPDPAGRFRAELRGGPGRWVVEAVVEQPNGADHKVVTLYSA
>NZ_CP022310.1|WP_142234101.1|2918210_2920172_+|pentapeptide-repeat-containing-protein
MVPPPGTTASEAPDWPQCAHGSGADRCRGRRVDPHPACLAHLGSAERAGHLAGLRPGAALDHRGTPFTPDLLDELLAALDDPATGRRVLGPAEFDEAHFSGEAMFERVDFTGDVSFGGARFGGAHFTGSRFGGGIGFGEAEVARDAWFDDVQVDADAWFYGARIGGALRFPSARIGGSAVFNGLVAGGDVTFGAAAFDGTALFTGAEIAGEAWFDGARFADDASFDRLRTGRPALFDGALFQGEACFDLAVIGDDISFRDTEFRRGAGFSGATFGGGVALRGCGTGGDITFRGATFQRTTVLGPLALPGLLDLSDAVFQSAVTVEAAARDLRCRRTRWASTAALRLRHARVDVRDAVLEFPVSIASRSRRFVADDGREIDEPGLTDARVRVVSLSGADAAHLVLTDVDLTDCLFAETVHLDQLRLGGRCPLALPPSGIRWTRRRTLIEEHHWRAERHGGPGWTPAPPGTDVRAPAVLAPVYRQLRKALEDGRNEPGAADFYYGEMEMRRHDPETPRGERVLLGLYWAVSGYGLRATRALGWLLLAVVATVLAMTLWGLPQDDPRQTSTGRVSGGGITLTTEKPDPVNPQGPYARRLSGKRAEKALRTVVNSVVFRSSGQELTTAGTYIEMTSRVVEPALLGLAVLAVRSRVKR

Crispr_ID: NZ_CP022310_5

• CRISPR_ID: NZ_CP022310_5
• CRISPR_location: 2972447-2972994
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 8 spacers

Consensus repeat of NZ_CP022310_5

Consensus_repeat	Method
GNNGNNGNNNGNNNNNGCAGGTNCGGCGAGGGCGGTCGCGCGG	CRT

spacers of NZ_CP022310_5

>5.1|2972490|19|NZ_CP022310|CRT
TGAGTGCGGGTACGTCACT
>5.2|2972552|22|NZ_CP022310|CRT
CGTCCTCGGGCGTGTCAAGGCC
>5.3|2972617|19|NZ_CP022310|CRT
TGAGTGCGGGTACGTCACT
>5.4|2972679|22|NZ_CP022310|CRT
CGTCTTCGGGCGCGTCAAGGCC
>5.5|2972744|19|NZ_CP022310|CRT
TGAGTGCGGGTACGTCACG
>5.6|2972806|19|NZ_CP022310|CRT
TGAGTGCGGGTACGTCGCG
>5.7|2972868|22|NZ_CP022310|CRT
CGTCCTCGGGCGCGTCAAGGCC
>5.8|2972933|19|NZ_CP022310|CRT
TGAGTGCGGGTACGTCACG

CRISPR arrays and Neighbor proteins around NZ_CP022310_5

CRISPR arrays

The CRISPR arrays of NZ_CP022310_5

>merge|NZ_CP022310|5|2972447-2972994|CRT
GTCGCGGGCGGCGAGTGCGGGTGCGGCGAGGCTGGTCGCGCGGTGAGTGCGGGTACGTCACTGCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGGCGTCCTCGGGCGTGTCAAGGCCGTCGCGGGCGGTGAGTGCAGGTACGGCGAAGGCGGTCGCGCGGTGAGTGCGGGTACGTCACTGCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGGCGTCTTCGGGCGCGTCAAGGCCGTCGCGTGCGGTGAGTGCGGGTGCGGCGAGGCTGGTCGCGCGGTGAGTGCGGGTACGTCACGGCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGGTGAGTGCGGGTACGTCGCGGCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGGCGTCCTCGGGCGCGTCAAGGCCGTCGCGTGCGGTGAGTGCAGGTACGGCGAGGGCGGTCGCGCGGTGAGTGCGGGTACGTCACGGCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGG

>NZ_CP022310|5|2|2972447-2972994|CRT
GTCGCGGGCGGCGAGTGCGGGTGCGGCGAGGCTGGTCGCGCGG	TGAGTGCGGGTACGTCACT
GCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGG	CGTCCTCGGGCGTGTCAAGGCC
GTCGCGGGCGGTGAGTGCAGGTACGGCGAAGGCGGTCGCGCGG	TGAGTGCGGGTACGTCACT
GCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGG	CGTCTTCGGGCGCGTCAAGGCC
GTCGCGTGCGGTGAGTGCGGGTGCGGCGAGGCTGGTCGCGCGG	TGAGTGCGGGTACGTCACG
GCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGG	TGAGTGCGGGTACGTCGCG
GCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGG	CGTCCTCGGGCGCGTCAAGGCC
GTCGCGTGCGGTGAGTGCAGGTACGGCGAGGGCGGTCGCGCGG	TGAGTGCGGGTACGTCACG
GCGGTCGCGCGGCGACGCAGGTTCGGCGAGGGCGGTCGCGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142232023.1|2968958_2969540_+|VanZ-family-protein	unknown	unknown	gnl|CDD|377417
NZ_CP022310.1|WP_142193523.1|2969913_2970258_-|ATP-binding-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142193535.1|2984076_2985123_-|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380577
NZ_CP022310.1|WP_142232024.1|2970402_2971554_-|adenosine-deaminase	unknown	unknown	gnl|CDD|236480
NZ_CP022310.1|WP_142193531.1|2979528_2979927_-|cytidine-deaminase	unknown	unknown	gnl|CDD|180142
NZ_CP022310.1|WP_142193527.1|2974208_2975489_+|MFS-transporter	unknown	unknown	gnl|CDD|340882
NZ_CP022310.1|WP_142232026.1|2982318_2983878_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|226364
NZ_CP022310.1|WP_142193516.1|2963738_2964452_+|uridine-kinase	unknown	unknown	gnl|CDD|238981
NZ_CP022310.1|WP_142193522.1|2969600_2969801_+|PspC-domain-containing-protein	unknown	unknown	gnl|CDD|377200
NZ_CP022310.1|WP_142193528.1|2975652_2976675_+|RNA-polymerase-subunit-sigma-70	unknown	unknown	gnl|CDD|236196
NZ_CP022310.1|WP_142193530.1|2978159_2979443_-|thymidine-phosphorylase	unknown	unknown	gnl|CDD|180276
NZ_CP022310.1|WP_142193518.1|2965925_2966621_+|two-component-system-response-regulator-AfsQ1	unknown	unknown	gnl|CDD|223816
NZ_CP022310.1|WP_142193517.1|2964950_2965700_-|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132028
NZ_CP022310.1|WP_142232025.1|2977097_2978018_+|AEC-family-transporter	unknown	unknown	gnl|CDD|223751
NZ_CP022310.1|WP_142193519.1|2966617_2968225_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NZ_CP022310.1|WP_142193532.1|2979923_2981198_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224005
NZ_CP022310.1|WP_142193526.1|2973182_2974145_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176125
NZ_CP022310.1|WP_142193533.1|2981194_2982319_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|226962
NZ_CP022310.1|WP_142193520.1|2968225_2968849_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142193525.1|2971668_2972430_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223477

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142232023.1|2968958_2969540_+|VanZ-family-protein	gnl|CDD|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	6.42145e-21
NZ_CP022310.1|WP_142193535.1|2984076_2985123_-|BMP-family-ABC-transporter-substrate-binding-protein	gnl|CDD|380577	cd06354, PBP1_PrnA-like, periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. The PnrA lipoprotein, also known as Tp0319 or TmpC, represents a novel family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC) transport system (pnrABCDE). It shows a striking structural similarity to another basic membrane lipoprotein Med which regulates the competence transcription factor gene, comK, in Bacillus subtilis. The members of PnrA-like subgroup are likely to have similar nucleoside-binding functions and a similar type 1 periplasmic sugar-binding protein-like fold.	1.7319e-96
NZ_CP022310.1|WP_142232024.1|2970402_2971554_-|adenosine-deaminase	gnl|CDD|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	8.50219e-156
NZ_CP022310.1|WP_142193531.1|2979528_2979927_-|cytidine-deaminase	gnl|CDD|180142	PRK05578, PRK05578, cytidine deaminase; Validated.	2.07325e-72
NZ_CP022310.1|WP_142193527.1|2974208_2975489_+|MFS-transporter	gnl|CDD|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.27412e-68
NZ_CP022310.1|WP_142232026.1|2982318_2983878_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|226364	COG3845, COG3845, ABC-type uncharacterized transport systems, ATPase components [General function prediction only].	0
NZ_CP022310.1|WP_142193516.1|2963738_2964452_+|uridine-kinase	gnl|CDD|238981	cd02023, UMPK, Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.	9.07389e-13
NZ_CP022310.1|WP_142193522.1|2969600_2969801_+|PspC-domain-containing-protein	gnl|CDD|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	3.27338e-21
NZ_CP022310.1|WP_142193528.1|2975652_2976675_+|RNA-polymerase-subunit-sigma-70	gnl|CDD|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	3.04215e-180
NZ_CP022310.1|WP_142193530.1|2978159_2979443_-|thymidine-phosphorylase	gnl|CDD|180276	PRK05820, deoA, thymidine phosphorylase; Reviewed.	0
NZ_CP022310.1|WP_142193518.1|2965925_2966621_+|two-component-system-response-regulator-AfsQ1	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.40148e-82
NZ_CP022310.1|WP_142193517.1|2964950_2965700_-|SigE-family-RNA-polymerase-sigma-factor	gnl|CDD|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	3.57062e-64
NZ_CP022310.1|WP_142232025.1|2977097_2978018_+|AEC-family-transporter	gnl|CDD|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	1.48755e-41
NZ_CP022310.1|WP_142193519.1|2966617_2968225_+|HAMP-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.22675e-49
NZ_CP022310.1|WP_142193532.1|2979923_2981198_-|ABC-transporter-permease	gnl|CDD|224005	COG1079, COG1079, Uncharacterized ABC-type transport system, permease component [General function prediction only].	1.36295e-79
NZ_CP022310.1|WP_142193526.1|2973182_2974145_-|LysR-family-transcriptional-regulator	gnl|CDD|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.84697e-89
NZ_CP022310.1|WP_142193533.1|2981194_2982319_-|ABC-transporter-permease	gnl|CDD|226962	COG4603, COG4603, ABC-type uncharacterized transport system, permease component [General function prediction only].	5.77698e-73
NZ_CP022310.1|WP_142193525.1|2971668_2972430_+|alpha/beta-hydrolase	gnl|CDD|223477	COG0400, COG0400, Predicted esterase [General function prediction only].	0.00134221

Protein sequences

>NZ_CP022310.1|WP_142193525.1|2971668_2972430_+|alpha/beta-hydrolase
MAQEATPVRRARLGRALGPEPTAVSGVVLLLPGGEEVSSRRPSPMVAAASVHGLGRRLTRAARDRSLAAHVVHYRYRGWNGSEAHLARDAAWAADEAVRRYGDVPVCLAGLGMGGRAALRAGGHEAVNSVLALAPWLPEEDVAAPPEPVKQLAGRQVLIVHGTNDARTDPELSFRLAARAKKANREVCRFEVHSDGHGLSQYRDEVLALAEDFVMGALFGRAFSRPVQDALAAPPPLGLRMPLAAGFGRSLRR
>NZ_CP022310.1|WP_142232024.1|2970402_2971554_-|adenosine-deaminase
MTSQTIANTPDPDRIRRAPKVLLHDHLDGGLRPGTVAELALETGYTGLPETDPDKLALWFHQAADSGSLERYLETFSHTVGVMQTRDALVRVAAECAEDLAEDGVVYAEVRYAPEQHLDGGLTLEEVVEAVNEGFRQGERRARENGHRIRVGALLTAMRHAARALEIAELANRYRDLGVVGFDIAGAEAGYPPTRHLDAFEYLKRANNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVRIIDDIHVRDDGTVELGRLASYVRDKRIPLELCPSSNLQTGAAPSYAEHPIGLLRQLHFRATVNTDNRLMSHTSMSREFEHLVDAFGYTLDDLQWFSVNAMKSAFIPFDERLAMINDVIKPGYAELKSEWLFRHTASTSGFTGK
>NZ_CP022310.1|WP_142193523.1|2969913_2970258_-|ATP-binding-protein
MKQSAAKTLGVAALGAAFAAAGAGAANAAPALPDAPSLDTVTQAAPAEQLSGALPGSGQVLATGQELVGRGTAAVQPAVGRLAPQVPAAGLLGGLPVQGVPTQGLAVNGLPLGG
>NZ_CP022310.1|WP_142193522.1|2969600_2969801_+|PspC-domain-containing-protein
MSRLARPTNDRMIGGVCAALARRFGTSATTMRVIFLISCLLPGPQFLLYIALWILLPSEEKTRTAW
>NZ_CP022310.1|WP_142232023.1|2968958_2969540_+|VanZ-family-protein
MQRQGFVGGSAAFRFRVSGGLLLAAYLAFVAWFTLRPLDVPWVMPANWRPLDGIRADFALGWVEGVRRVGEGLALLAPLGVLLPMAGGRLCVSGLGSLIRAMAATALVSLAVEMLQTAVPGQVVDIDSLLLNTVGAGLAHAAVVPAGRSWLRRRAGLPSGTALPAEEPAQGRTPTIPRVGIAPWSDALPPSSP
>NZ_CP022310.1|WP_142193520.1|2968225_2968849_+|hypothetical-protein
MDVRRGTVRRLPVLLALGVLGGALAGCGIRATEVPTDFGPAPSRVSCSLAEPEVTTQAVRGLPVRVFLLCGSSLVSVDRTVRVPDGAADSRRVTVAQGLLDELSRQPTAAEQEAGYTTRVRGGTTVSGPRPGDPEDTLRLSTAPGSLSAAGLAQIVCTFSDSAAAEGDGSVVLGGPDDGRPRRYECTDEVRARPDAGQPPSSETTGN
>NZ_CP022310.1|WP_142193519.1|2966617_2968225_+|HAMP-domain-containing-protein
MTEEHQGGSRGWSAARKGIWSRLRFTSLRLRLVVVFGLVALTAAVSASGIAYWLNRESVLTRTQDAVLRDFEQEMQNRAGALPEHPTQDELQRTAGQMANTGQGFTVLLVAENPDGRTVYGSSGGLNGFSLQDVPASLREAVTERQKVTATNKYPHRLYWQRTVESDVPYLVAGTRVIGGGPTGYMLKSLEPEAKDLNSLAWSLGIATGLALIGSALLAHAAATTVLKPVQRLGVAARRLGEGKLDTRLRVSGTDELADLSRTFNKAAEALEKRVADMAARDEASRRFVADMSHELRTPLTAITAVTEVLEEELEFEGGGIDPMIEPAVRLVVSETRRLNDLVENLMEVTRFDAGTARLVLDDVDIADQITACIDARAWLDAVELDAERGIHARIDPRRLDVILANLIGNALKHGGSPVRVAVREETAAGPEGAADEGVVVIEVRDHGPGIPEEVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSPEGGAVFTLRLPRDVSAQSPSEQAGDTKDEGAEGDA
>NZ_CP022310.1|WP_142193518.1|2965925_2966621_+|two-component-system-response-regulator-AfsQ1
MGQNEPVPSLLLIEDDDAIRTALELSLTRQGHRVATAASGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARSDDIDVVVGLESGADDYVVKPVQGRVLDARIRAVLRRGERESSDSATFGSLVIDRAAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDPPQ
>NZ_CP022310.1|WP_142193517.1|2964950_2965700_-|SigE-family-RNA-polymerase-sigma-factor
MNTLHGTMTSAVVTRLHDVHRGSEKSGAVSGRGCARGTGRQHTAIMTVVDAPTGETHGGNTYGEGSGERRQARQADAEAAFTAYVQERRASLYATAYHLTGDRFEAEDLLQSALFSTYRAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETPGDTDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIADILGISVGTVKSSIWRSLRRLREDEVLSFGRDEEDAFGELVA
>NZ_CP022310.1|WP_142193516.1|2963738_2964452_+|uridine-kinase
MTRASKPYRGVVHRPNDASHWCPVSSQSPISARVVLLCGPSGSGKSLLAARSGLPVLRLDDFYKEGDDPTLPLMAGTSDIDWDHPASWDADTAVAAIERLCRTRRTQVPVYDIALSARTGEATVDIAGTPLFIAEGVFAAEIVSRCREAGLLADALCLSRGPVRTFRRRFLRDLREGRKSVPFLLRRGWRLMRQERSIIARQTALGAYACDRDEALGRLASAAVAGRTATGTTSTAA
>NZ_CP022310.1|WP_142193526.1|2973182_2974145_-|LysR-family-transcriptional-regulator
MAHEQRSHGRLSQTSDTRDTADMSRLLAPRLAHFAGVARTEHVTRAAQEMQVPQSTLSRAMVRLEQDLGVDLFARHGRTVSLTPAGRTFLASVERALAEIERAAEEVRADADPATGKVAFGFLHTMGAETVPGLLHAFRADHPRIRFSLVQNYGEAMLERLRAGELDLCLTSPVPDAPDLVARRLDEQKLRLVVPPDHRLAGRRRIRLAEAADETFVTLEPGYGLRRITDDLCAQAGFRPRIAFEGEEAETLRGLVAAGLGVALLPPPAFPRPGVVELTVTAPKAAREIGVAWLAGRPDTPPVAAFKKFLLSKRGSLLPT
>NZ_CP022310.1|WP_142193527.1|2974208_2975489_+|MFS-transporter
MTPASTGASTTVGAVASVPSVPSSSESRMSPGGPGYRRMSLALFLAGVATFALLYSTQALLPLISADFAVSAGDASWTVAAATGGLAVFVLPMSALSERYGRRTVMTASLAVAVTVGLLVPFAPSLGALVALRALQGAALAGLPASATAYLAEEVTPKALVTAIGLFVAGNSVGGMSGRVITGWVAQEWGWRVAVGVIGAVAVACAVAFRLLLPAPRHFRPGSLRPRVLARTVRGHLANPLLRRLYAIGALFMTVFGGVYTVIGYRLTEAPFSLPQGIVGSIFLVYLVGTVSASAAGRLVGRLGRRGALYAAGGTTAAGLLLSLADALPLVLLGLVLITGGFFAGHAVASSAVGRTATEGRAQASALYQSAYYVGSSAGSTAGALAFHSGGWAGTVGVGLVAVAGVAAITLAGTRAARAERRPATA
>NZ_CP022310.1|WP_142193528.1|2975652_2976675_+|RNA-polymerase-subunit-sigma-70
MTNGTATTDLDARLEAHRVELTGYCYRMLGSSFEAEDAVQDTMVRAWRSYDKFEGRSSLRSWLYRIATNVCLDMLSAGNKRARPMDLTESTPLARAALSPRPDHTWLEPMPDARVLPTPTDPAEAAVAKESVRLAFMAALQQLPAKQRAVLILREVLAWKASEVAELLDTSVASVNSALQRARATLAERQQPGADAAVSDPLDEEQQKLLERYVAAFEGYDMSALTALLHEDAIMTMPPFDLWLTGPEDITGFMTTLGAACASSRLIPVEVNGLPGFAQYKPDPEAGGFVPWAVQALEISGDRISGFHCFLDTQRWFPLFGLPLRLEAESDQVEQGAQGR
>NZ_CP022310.1|WP_142232025.1|2977097_2978018_+|AEC-family-transporter
MQGVLSGFLVIAVVIGVGYAIGRRGDLGEQGREVLTKLAFHVASPALLFTTLARADLSVIFSSRLLVTALSTAAVAGVFVAVGVARGWGVGRTTIGALCSSYVNSGNLGIPIAVYVLGDASLVAPVLLFQLVGVTPVALTILDLSTAGEKGPLWRRLLTPLRNPIAIGSLAGVAVSATGVRIPGPVMDPVTLIGNMAVPAVLLAFGISLRGSTLPLRTGERGPVLLAVALKAVGQPLVAWALAVGVFGLRGAHLLDVVVTSALPAAQNLFTYASSYRVGETLAREAILVSTVVSVPVLVVVAALLG
>NZ_CP022310.1|WP_142193530.1|2978159_2979443_-|thymidine-phosphorylase
MAMDAISVIRTKRDRGELGDEQIDWVIDAYTRGEVADEQMSALAMAILLNGMNRREIARWTAAMIASGERMDFSSLSRPTADKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKLESIPGWRALLSNEEMLNVLDTTGAVICAAGDGLAPADKKLYALRDVTGTVEAIPLIASSIMSKKIAEGTGSLVLDVKVGSGAFMKTIDDARELASTMVGLGTDSGVRTVALLTDMATPLGLTAGNALEVRESVEVLAGGGPADVVELTLALAREMLDAAGLKDADPAKALADGSAMDVWRRMIAAQGGDPDAALPTAREQHVVKAPATGVLTRLDAYDIGVAAWRLGAGRARKEDPVQAGAGIEMHAKPGDTVTEGQPLLTLHTDTPERFAYALQAVEGSYDIAAPGTPFAATPVVLERIA
>NZ_CP022310.1|WP_142193531.1|2979528_2979927_-|cytidine-deaminase
MTAHDVDWEALRAAARDAMSHAYAPYSGYPVGVAALVDDGRTVSGCNVENASYGLGLCAECGLVSELQRTGGGRLTHFTCVDGEGEILVPCGRCRQLLYEFGGPGLLLETPAGILPLSEMLPQAFGPQHLTK
>NZ_CP022310.1|WP_142193532.1|2979923_2981198_-|ABC-transporter-permease
MTAPTTATDVNQPSLEHAPKAGRRLSWPVLLLVIAGALALTSIVRLITGADGITNVSQMSTALQLAVPIGLAGLGGLWAERAGVVNIGLEGMMILGTWFGAWAGFQWGPWTGVLVGILGGAIGGLLHAIVTVTFNVNHIVSGVALNILALGATRYLAPLAFEGHQGGSAKQSPAVESLGHFTVPGLSDALSDLNDKGWFFVSDIAGLLGGLVTGVSWLTLIAVALVPATWWILWRTAFGLRLRSCGENPVAAESLGVNVYKYKYLAVIISGGLAGLGGVFLSIVANPFYLEGQTSGRGYIGLAAMIFGNWMPGGLAIGAGLFGYTDSLNLRGGSANVHALLLLGALLLLIGAIWLVVRKKYVHAVITLVVGALVFAWYAGTNEVPNQVVSATPYVITLVVLALSAQRLRMPKADGMPYRKGQGK
>NZ_CP022310.1|WP_142193533.1|2981194_2982319_-|ABC-transporter-permease
MKKFDKERVLLAVAGPVIALAVAFALSAIVLIASGKNPVEPFALMFEQAGFSDIQVLIINQASMYYIAALAVAIGFRMNLFNIGVDGQYQLAAMMAAIVGAHMNLPAALQIPLLLLTAVFTGAFWSGIAGVLKVTRGVSEVVATIMLNAIATSVIGYLWLPTVFGVKVGNNNTTGEMHSSGWVPGIDMGEAGEIYGLVILAVLLGIGYWVVLNRTRFGFDLRASGASESAAAASGVSPKRMVLTAMLLSGALAGLAGLPILMGDTHTYSLNFPTGIGFLGIGIALLGRNSPVGIAFAALLWAWLDKASPELDFHGYDKEIAVIMQGLIVLSVVVSYEAVREWGLRRQQRRVGAELAAGHVLGADNNTTKEVAGR
>NZ_CP022310.1|WP_142232026.1|2982318_2983878_-|ATP-binding-cassette-domain-containing-protein
MTAVELAGITKRFPGVVANHDIHLTVRKGTVHALVGENGAGKSTLMKILYGMQKPDEGTIAVHGEKVSFSSPADAIVRGIGMVHQHFMLADNLTVLENVVLGSEKLYGIGGRARRKIKELSDRYGLGVRPDVLVEELGVAARQRVEILKVLYRGATTLILDEPTAVLVPQEVDALFDNLRELKAEGLSVIFISHKLGEVLSVADEITVIRRGTTVGTAVPAETTPRQLAEMMVGSELPTPETAESTVTDRPVLTVDKLRLTAPGGKALLDDISFTIHAGEVLGIAGVEGNGQTELVDALIGLRHADSGVIRLADEEITAWPTRRRREEGIGYIPEDRHRHGLLLEAPLWENRILGHVTEKPNAKGVWLDPKAAQDDTRRIVQAYDVRTPGIDVTAASLSGGNQQKLIVGREMSHKPRFLIAAHPTRGVDVGAQAAIWDHIREARREGLAVLLISADLDELIGLSDTLRVIYDGKLVADADPAAITPEELGTAMTGAASGHLEHEETPADGGRGAEDEGR
>NZ_CP022310.1|WP_142193535.1|2984076_2985123_-|BMP-family-ABC-transporter-substrate-binding-protein
MRRISRITVAGAATASLALALSACGGTSTSSSSESKGDKGLAIAYDVGGKGDQSFNDAAYAGLEKAKKEFGYETADVEPTEGETDADKEQRLASLAKQGYNPVIGVGYAYAAAVKGAAEKFPDTTFGIVDDATIEAENVADLVFSEEQASYLAGVAAAKATKTKTVGFVGGVDIPLIHKFQAGFEQGVKDTDPKVKVLPQYLTQTAEEGGFSSPDKGKTAAEGQIEKKADVVYAAAGLSGQGVIEAAAANKVWAIGVDSDQYQQEALAKYKDYILTSAMKDVAKAVYNLAKSVEDGKPETGIVRGDLKTGEVSLSNSNPKFADDAELQEAIETAKEKIISGEIKVKSS

Crispr_ID: NZ_CP022310_6

• CRISPR_ID: NZ_CP022310_6
• CRISPR_location: 3193902-3194060
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_6

Consensus_repeat	Method
CGGTCGTCCGGGTCGGGCTCGGCTGCGGTGCGGGCCGT	CRISPRCasFinder

spacers of NZ_CP022310_6

>6.1|3193940|83|NZ_CP022310|CRISPRCasFinder
CCGGTCGTCCGGGTCGGGCTCGGCTGCGGTGCGGGCCGTGCGGTCGTCCGGTCGTCAGGGCCCGGGGCGGGGTGTGTGCCGTG

CRISPR arrays and Neighbor proteins around NZ_CP022310_6

CRISPR arrays

The CRISPR arrays of NZ_CP022310_6

>merge|NZ_CP022310|6|3193902-3194060|CRISPRCasFinder
CGGTCGTCCGGGCCGGGCTCGGCTGCGGTGCGGGCCCTCCGGTCGTCCGGGTCGGGCTCGGCTGCGGTGCGGGCCGTGCGGTCGTCCGGTCGTCAGGGCCCGGGGCGGGGTGTGTGCCGTGCGGTCGTCCGGGCCGGGCTCGGCTGCGGTGCGGGCCGT

>NZ_CP022310|6|4|3193902-3194060|CRISPRCasFinder
CGGTCGTCCGGGCCGGGCTCGGCTGCGGTGCGGGCCCT	CCGGTCGTCCGGGTCGGGCTCGGCTGCGGTGCGGGCCGTGCGGTCGTCCGGTCGTCAGGGCCCGGGGCGGGGTGTGTGCCGTG
CGGTCGTCCGGGCCGGGCTCGGCTGCGGTGCGGGCCGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142232113.1|3194474_3195494_-|hypothetical-protein	unknown	unknown	gnl|CDD|237057
NZ_CP022310.1|WP_142232112.1|3193115_3193778_-|HAD-hydrolase-like-protein	unknown	unknown	gnl|CDD|223620
NZ_CP022310.1|WP_142194661.1|3195611_3198269_+|DNA-binding-protein	unknown	unknown	gnl|CDD|379300
NZ_CP022310.1|WP_161174926.1|3201327_3201513_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142194671.1|3185760_3186369_-|hypothetical-protein	unknown	unknown	gnl|CDD|377817
NZ_CP022310.1|WP_142232116.1|3200861_3201242_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232117.1|3204893_3205574_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NZ_CP022310.1|WP_142194665.1|3192325_3192709_-|cold-shock-domain-containing-protein	unknown	unknown	gnl|CDD|224197
NZ_CP022310.1|WP_142194657.1|3204117_3204807_-|copper-homeostasis-protein-CutC	unknown	unknown	gnl|CDD|225684
NZ_CP022310.1|WP_142194666.1|3191391_3192312_+|1,4-dihydroxy-6-naphthoate-synthase	unknown	unknown	gnl|CDD|270353
NZ_CP022310.1|WP_142234113.1|3201958_3203998_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226482
NZ_CP022310.1|WP_142194977.1|3190230_3190683_+|DUF2771-domain-containing-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232115.1|3199115_3200759_+|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl|CDD|223989
NZ_CP022310.1|WP_142194664.1|3192873_3193134_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232114.1|3198801_3198987_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_167530042.1|3190652_3191411_+|futalosine-hydrolase	unknown	unknown	gnl|CDD|236194
NZ_CP022310.1|WP_167530043.1|3205684_3207535_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173820
NZ_CP022310.1|WP_142232110.1|3188711_3190145_+|MFS-transporter	unknown	unknown	gnl|CDD|340863
NZ_CP022310.1|WP_142194672.1|3181873_3185005_-|molecular-chaperone-Hsp90	unknown	unknown	gnl|CDD|237603
NZ_CP022310.1|WP_142194669.1|3187465_3188392_-|DUF3027-domain-containing-protein	unknown	unknown	gnl|CDD|378605

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142232113.1|3194474_3195494_-|hypothetical-protein	gnl|CDD|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	4.34512e-08
NZ_CP022310.1|WP_142232112.1|3193115_3193778_-|HAD-hydrolase-like-protein	gnl|CDD|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.77286e-22
NZ_CP022310.1|WP_142194661.1|3195611_3198269_+|DNA-binding-protein	gnl|CDD|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	1.20119e-43
NZ_CP022310.1|WP_142194671.1|3185760_3186369_-|hypothetical-protein	gnl|CDD|377817	pfam07336, ABATE, Putative stress-induced transcription regulator. The structure of one member of the ABATE domain family consists of a two-domain organisation, with the N-terminal domain presenting a new fold called the ABATE domain that may bind an as yet unknown ligand. The C-terminal domain forms a treble-clef zinc-finger that is likely to be involved in DNA binding. suggests a role as stress-induced transcriptional regulator. Further computational analyses sugeests a role as a stress-induced transcriptional regulator. Members of this family are found in Streptomyces, Rhizobium, Ralstonia, Agrobacterium and Bradyrhizobium species.	1.44861e-10
NZ_CP022310.1|WP_142234113.1|3201958_3203998_+|AAA-family-ATPase	gnl|CDD|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	3.25461e-68
NZ_CP022310.1|WP_142232117.1|3204893_3205574_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	5.65737e-17
NZ_CP022310.1|WP_142194665.1|3192325_3192709_-|cold-shock-domain-containing-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	5.73358e-27
NZ_CP022310.1|WP_142194657.1|3204117_3204807_-|copper-homeostasis-protein-CutC	gnl|CDD|225684	COG3142, CutC, Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism].	8.49561e-23
NZ_CP022310.1|WP_142232110.1|3188711_3190145_+|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.7897e-28
NZ_CP022310.1|WP_142194672.1|3181873_3185005_-|molecular-chaperone-Hsp90	gnl|CDD|237603	PRK14083, PRK14083, HSP90 family protein; Provisional.	0.00138915
NZ_CP022310.1|WP_167530042.1|3190652_3191411_+|futalosine-hydrolase	gnl|CDD|236194	PRK08236, PRK08236, hypothetical protein; Provisional.	6.3833e-81
NZ_CP022310.1|WP_167530043.1|3205684_3207535_-|S8-family-serine-peptidase	gnl|CDD|173820	cd07496, Peptidases_S8_13, Peptidase S8 family domain, uncharacterized subfamily 13. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	4.13793e-116
NZ_CP022310.1|WP_142194666.1|3191391_3192312_+|1,4-dihydroxy-6-naphthoate-synthase	gnl|CDD|270353	cd13635, PBP2_Ttha1568_Mqnd, A menaquinone biosynthetic enzyme exhibits the type 2 periplasmic-binding protein fold. This group includes Ttha1568 (MqnD) from Thermus thermophilies HB8, an enzyme within an alternative menaquinone biosynthetic pathway that catalyzes the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate. Menaquinone (MK; vitamin K) is an essential lipid-soluble carrier that shuttles electrons between membrane-bound protein complexes in the electron transport chain. Ttha1568 has significant structural homology with the members of type 2 periplasmic-binding fold protein superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.52467e-140
NZ_CP022310.1|WP_142232115.1|3199115_3200759_+|DEAD/DEAH-box-helicase-family-protein	gnl|CDD|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	3.35578e-110
NZ_CP022310.1|WP_142194669.1|3187465_3188392_-|DUF3027-domain-containing-protein	gnl|CDD|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.19183e-103

Protein sequences

>NZ_CP022310.1|WP_142232112.1|3193115_3193778_-|HAD-hydrolase-like-protein
MASTTAPQPTVGFDLDMTLIDSRPGIRACYQALSERTGTYIDADLAVTRLGPPLVDELAHWFPAARIEETADLYRAMYPSYAIAATPALPGAREAIAAVREAGGRAIVVTAKYEPNAKLHLAHLGIEPDAVIGDLWAEQKALALREHGASVYVGDHVGDVRGARTAGALSVAVATGPCDETELRTAGADVVLTDLTEFPRWFSDYRTDNRTDRRDYRSGN
>NZ_CP022310.1|WP_142194664.1|3192873_3193134_+|hypothetical-protein
MRDKTQANSSAPGDGLVRAGALVFFVGAVATLVTVAPLFLGTTPFPTYMFGLSMLMAVGFLMAGAGVMRSVAAGRRRARAGQLPER
>NZ_CP022310.1|WP_142194665.1|3192325_3192709_-|cold-shock-domain-containing-protein
MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPAGVEALKPGQRVEFGVVAGQRGDQALSLTILDPTPSVAAAQRKKPDELASIVQDLTTLLENITPQLERGRYPDRAAGKKIAGLLRAVADQLDV
>NZ_CP022310.1|WP_142194666.1|3191391_3192312_+|1,4-dihydroxy-6-naphthoate-synthase
MTAMTSEPPQVRIAYSPCPNDTFVFDALAHGRVPGAPAVDVTFADIDITNGMAERGELDVLKVSYAVLPYVLDQYALLPCGGALGRGCGPLVLTREEGLDLAGRTVAVPSERSTAYLLFRLWAADVVGTRRGGPAGPSVEGGGGRRAGGVGEIVVMPFHEIMPAVRDGKVDAGLVIHEARFTYHTYGLHKLADMGEHWERTTGLPIPLGAIIARRSLGEAALTRLADSIRASVRAAWDDPEASRPYVMEHAQEMDPAVADQHIGLYVNEFTADLGEDGYAAVRGLLTRAAAEGLVPPLGPDALRFP
>NZ_CP022310.1|WP_167530042.1|3190652_3191411_+|futalosine-hydrolase
MVLPAEEGRLITSSVRVLVATAVPVERDAVARAFPGPVRETVRPSVTVHEVTGGPDLLAAGVGPALAAASTAGALTAAALDGRPYGLVVSAGIAGGFPPHAPLGSLVVADEITAADLGAETADGFLPVTDLGFGTVTHRPPAALVRAAAAAAGALTGTVLTVSTVTGTAARAAELRGRHPRALAEAMEGFGVAEAAAAHGVPVLEVRAVSNPVGPRDRAAWRIGDALDALTEGFGKLAPVLESWKQHDRHDQ
>NZ_CP022310.1|WP_142194977.1|3190230_3190683_+|DUF2771-domain-containing-protein
MRRRRAVAAAGAVSAGLLVLAACDKPTPMATITVGSDTVSSEATCGGEGEALKAADLNACLKDKGIDEISVDPDATVRFGVDPEVADKGWTILMNGQPLTDSSTKTYRTIPGSVFFNAQYGAQGDSTLVSIKEGEEDTTGLWSFRLKKDA
>NZ_CP022310.1|WP_142232110.1|3188711_3190145_+|MFS-transporter
MATARTPQGATGTGGPKGVKGSGRRVRTGRTGGRLRAFGRALHFPVSGTARGIRRATHAHGAGESGLGKLIELHGVNGAGDVMITVALASTVFFSVPTDEARGRVALYLAITMAPFTLLAPVVGPLLDRLPHGRRAAMAGAMLARALLALVLSGAVVTGGIELYPAALGVLVSSKAYGVVRSAVVPRLLPPAFSLVKANSRVTLGGLLATGIAAPIGAGLQQVGPRWPLYGAFVIFVAGMFLSFRLPPKVDSAKGEDVALLAADEQHLHGPHRRPLKRPGLRTVGPAVTHALGANAAIRCLTGFLIFFLAFLLREHPMTGQSAAVSLGIVGVAAGAGNALGTAVGAWLRSRAPEVIIVTVVACVLGAAVLAALFFGAVLVACLAAVAGFAQALAKLSLDALIQRDVPELVRTSAFARSETLLQMSWVLGGAIGIAMPLIGTLGLAAGAAIVATGWLTTLRGLIRSARHGNAGRARVA
>NZ_CP022310.1|WP_142194669.1|3187465_3188392_-|DUF3027-domain-containing-protein
MSAATTRSRTPDRLCAEAVDLARAAAEEVAAPGVVGEYEGLVSEGDRVVTHFFACREAGYRGWRWAVTVARASRAKIVTIDEAVLLPGPDAVLAPEWVPWSERLRPGDMGPGDLLPTDAEDLRLEPGFSGEEEPPPNSAVSQDMAELVEAEDAEVTGGTPAHLAVAPTRGSIAAVAEELGMRRARVLSRYGLHSAADRWEEAFGAKTPMAQAAPASCVSCGFLTPIGGSLGQAFGVCANEFSPADGHVVSLAYGCGGHSEAAVMPKPPQPAPPVIDETRVDPFPLRPSPDSGSVPVTEDESSAELGHS
>NZ_CP022310.1|WP_142194671.1|3185760_3186369_-|hypothetical-protein
MRIVKEALMEEPALPPAQGEADHLSLALVNSAVALPGGHTADLLGTPARANHWLTERGLAPVDAGMREMCASQLRSLREQIRSLFASRAEGLPALPAALAAVNDAMTRVPTAPLLQWDAKTGPYRATPHPTSAIVDHALATLAADAADLLTSPAAERLTACGSAPCNRYLLRHGRRHWCSTRCGDRARAARAYARRTRPATD
>NZ_CP022310.1|WP_142194672.1|3181873_3185005_-|molecular-chaperone-Hsp90
MSKFVRPAAEGADPFATARLRRGVLDAWATSPARFREDANAEEDLVLGGYRDRLVVELAQNAADAAARAGVPGRLRLTLRDGVLVAANTGAPLDAAGVESLSTLRASAKRDESQRAVGRFGVGFAAVLSVTDEPAVVGRHGGVRWSLAEARELAGDTARHSPGLGDEIRRRDGHVPLLRLPFAAEGTAPGPYDTAVILPLRDAAAADLAERLLNAVDDALLLALPGLDEVVVEIGDAAPRTLGRRTEGALIVVEDSREGTTRWRTAAAHGPLTPDLLADRPVEERLRPHWSVTWAVPVDADGTPARPRTSPVVHAPTPSDEPLGVPALLIASLPLDSTRRHAAPGPLTDFLVQRAADAYAELLADWRPVTAGIIGLVPGPLGKGELDGALRQAILERLPRTSFLPPAAERREQDGDEELPESLRPRDAEVVEGAGADTVRVLAEVLPTLLPAGLERRVELRTLGVARVPLTDAIDRLAGLEKSPDWWRRLYDSLAGVDPDRLSGLPVPLADGRTTIGPRQVLLPTPDSASLDAELLARLGLKVAHPDAAHPILEKLGALPATPRAVLTTPQVRAAVAASLDDEGGMNWEEDAPDAEELADTVLGLVRDAGLEAGDEPWLGALALPDEDGELSPACELVFPGGPFARVMREGELAAVDAELAERWGEQPLAACGVLVDFALIRATDVVLDPDELEPREGDFAEPDDAGLLDAVDVWSEDILDRFPDSPVPPVATEIVAVRDLDLVDDDRWPQALALLSRPPLRDALVQPVRILLHDGTHEVVRPYTAWWLRGHPVLGGRRPAGLRAAGGDPLLRGLYDEADATGFEDEQVLRALGVRTSVAALLDEPGGAAELLDRLADPDRPVTAAQLHALYGALAELDPEQVTLPDELRAVVDGRVEVVDAADAVVVDSPDLLPFTGGVALLPVRPSRAAELAELFQVRRLSESVTGEVHSEGTEHEVPEPVRVLLGARTPASYVEHEELVVDGVEIDWRLTDDGVLHAATLEGVAAGLAWAAGQWPRRFEVAALLEDPSRTEELARDRWFD
>NZ_CP022310.1|WP_142232113.1|3194474_3195494_-|hypothetical-protein
MGIESDQVVYEYLSRVGDVAQQRQLPSAARMRLVAELRDEIDRRRARAVVDSPGAVRRIISRIGTPTEVVAAAEDASGTPASAPEPPAAVPEQREPERPAARAGRPKGVLRRAVPRPRPADTPDPAPAPAPATADAPSPPHRAGTDELGDSATQPDWWRVDDSPFGVGDEVPGFVGGVEIPELLKAPRTRDDDDTPPEPAADAAPAPAPEDEPAARRRFPRLVRLPSGRWSNPLLLLAAALLVAGAVIGDWRALVLGWLIAYASRRLTQAEIKWAVVILPGLSLAGGVVWLWGRTRGRWGDPIAEGHMNAAISETWPWVIRTAAVATALFLVWRSQRRG
>NZ_CP022310.1|WP_142194661.1|3195611_3198269_+|DNA-binding-protein
MSTEEKPAAAPRSLAEALRGRDDVSLAALLRSRPDLITPVPTDLTQLATRAGTRASVVRALERLDRFAVQTAQALAVAADPATYTELLGLLAGDDGDPAVSAALPHALATLREQALVWGDDTRLRLVRTARELLSPSPQHPSPTGLGPTVREAAAGMSPGRIQEIVSAAGLPSTHDAVSAVAALTELFNDPARMSALLDRAPAESLEVLERLVWGPPYGQVTADPAPRLRWLLDRGLLLPTAPGTVVLPREVALRLRGGRAHRSPEPVPPPVEAAAAHRPQVVDATAAGQAYTALATVEELLKDWHEGGPAVLRAGGLSVRDLKRTAVALDVPEPVAAFWVELAYAAGLLASDGEAEERYAATPAYDEWREQPPAQRWARLASAWLAATRTAGLVGGRDAKDRTLSALGPGLDRSAAPEVRHRVLTLLAGLPEGAAPVTESVLARLSWERPPRGGRGGAGPGTAGGSAAEGGRGASAAAGDGGRGTVGGVRAGDGEEDLRSRLARWALSEAEMLGVTGRGALSAHGRALIGAPAPRKPEAETEPEGPGDKLPVHHRPTPPPAPLSPADRATAAATAARLLAPLLPEPLDHVLLQADLTAVAPGPLERPLADMLSVLADVESKGGATVYRFTPGSVRRALDAGQTAADLHAFLAAHSRTPVPQPLAYLIDDVARRHGHLRVGAASAYVRCDDDAVLNEILADKRAAGLGLRRLAPTVLAAQAGPAGLLEGLRAMGFAPAAESAEGDVLIARADAHRTPPRSAPEPVPDGPPVPDDTLLTAAIRAIRAGDLASTAPRKPGAGDGPDRGELPRTTSAETLATVQAAVLTGASLWIGYVNAEGAASQRVIAPVRVEGGFVTAYDHTADEVRTYPLHRITGVAELSDDES
>NZ_CP022310.1|WP_142232114.1|3198801_3198987_+|hypothetical-protein
MRSLSRAVVGCLTAVALVTVLAPAATALPLPVPVAGVEPLLTEGVIVEGPLVNNLTLPVLK
>NZ_CP022310.1|WP_142232115.1|3199115_3200759_+|DEAD/DEAH-box-helicase-family-protein
MNGPLIVQSDKTLLLEVDHEQADDCRRVIAPFAELERAPEHIHTYRVTPLGLWNARAAGHDAEQVVDALVQYSRYPVPHALLVDIADTMDRYGRLSLVKHPAHGLVLTTTDRPVLEEVLRSKRITPLVGARIDPDTVVVHPSERGQIKQVLLKLGWPAEDLAGYVDGEAHAIELREDGWALRPYQKQAVENFWHGGSGVVVLPCGAGKTLVGAGAMAQAKSTTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTRKEIRPVTIATYQVLTTRRKGVYPHLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVSLTDSERLAYATAEQEEKYRYCSTTATKQKVTEAIVRRFAGQQILVIGQYIDQLDELGEHLNAPVIKGETSNAQREKLFDAFREGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHQAHFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIMDADELLTES
>NZ_CP022310.1|WP_142232116.1|3200861_3201242_-|hypothetical-protein
MSPHRPAAAPSVRQYRAERDRRAWVAPTVATVLGAVLTPSAVLLAAMSVMATDGCGPDDCSQALTTALSLIYSTLFFGGFLTTGAWFAAWLLPWTRRWSVLRAWLAGFSLLPPVLVLVMVFMLPAG
>NZ_CP022310.1|WP_161174926.1|3201327_3201513_-|hypothetical-protein
MSAATVNPAPPPVRPAGATAVQGSHPHRLGDALRAVKVFLGAAFDVIVLGEYGEEAGVRRR
>NZ_CP022310.1|WP_142234113.1|3201958_3203998_+|AAA-family-ATPase
MNDPADDPLSRERAHLSASRAALRAMREDVESLDITDVTANWVNAAVLERQIEERIKALADLSDTPLFFGRLDYLHSPGAEQAEGAEGERFYIGRRHVHDADGDPMVIDWRAPVSQPFYRASRKDPQDVALRRRFGYTGGDLTAYEDEHLTDPAEATTTSRLLQQEIERPRVGPMRDIVATIQPEQDEIVRSGLSGSVCVQGGPGTGKTAVGLHRVAYLLYAHRERLARTGTLVVGPNRSFLHYIEQVLPALGELTVAQATVDDLVAHVEVRGTDDAAAAVVKGDARMAQVLRRALYSHVTMPTEPVVVVRGSRRWRVAAYELQDIVRQLLDRDIRYGAARDALPQRIAHAVLVQMERAGEAPDDRVQDAVARNSAVKAAVKAVWPAVDPAKLVLRLLSDAEFLAEHAEGLLDEEERKAILWARPARSVKSAKWSSADAVLIDEAADLIQRTHSLGHVVLDEAQDLSPMQYRAVGRRCTTGSATVLGDLAQGTTPWATRSWQEALEHLGKPDAVVEELTAGFRVPTDVIAYASRLLPHIAPGLTPVASIRENPGFFEVRRIEDAGEVVDACRELLRNEGSTGLIAADARVPELAERLAAAGITFVAPGEETTHDTRLTLVPASLAKGLEYDYVVLDEPRAVVDAEPDERTGLRRLYVALTRAVSGLVVTHAAPLPEQLG
>NZ_CP022310.1|WP_142194657.1|3204117_3204807_-|copper-homeostasis-protein-CutC
MSKRAVLEVIALDVEDAVAARAGGADRLELVADMAADGLTPAAATVEKIRAAVDLPVRVMVRLADGFAAGDVERLVRAAREMRAAGAQEFVLGFLDADGCVDLAAVERVVGELDGCRWTFHRAIDRAADRDALRKRLDGLPGLDTYLTAGAAEGVDAGLPTLLAEAGRRGEPGYGPQLLVGGGLRLEHVPQLLAAGIDGFHIGGAARPRGWDGPVSAEAVAAWRDALDG
>NZ_CP022310.1|WP_142232117.1|3204893_3205574_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MTTPADVHDVRDPELPGRLLAVERDELVPLLRGRADADFALPVAACPGWTVRDVLAHCAAAFTRVRERRFEEGVFSPEANDRDIAERAEWSDQRVVDELERGMTEAGPLIAGAGGALDALALGEWVHAGDVREALGEPGAYAGAGLPYALTLLAQVTGRRGHLPLHADLDDADEPLRLGDFSGERPPARYIGDGPTLVRLYTGRPVRAAAYELAGVEAEELNIFGG
>NZ_CP022310.1|WP_167530043.1|3205684_3207535_-|S8-family-serine-peptidase
MDRTTAGAAFRSQLVKGSPTLNGSRRLRISLLAVTTAALLGSGLTAAVAAPAAQPAPADPKAAADAPVERLIVGYEKKAAEARSDAEARKDARAKGVRAGESLAFERRLGTGAALVDLGDELRGGSLQDVIDTFEADADVAYVARDTRMYAMAGPDDTYYSSQWDLFEATAGMNVENAWTGGASGQGVTVAVIDTGHVPHSDLDANVVAGYDFISDAWSARDGGGRDGNPRDEGDWTLENDCYSGSRASNSSWHGTHVAGTVAAVAGNGKGVAGVAFDASVQPVRVLGRCGGSTADIADAIVWASGGSVPGVPSNPTPADVINLSLGGSGSCQTVTQDAINGAVSRGTTVVVAAGNSNTDASGFTPANCGNVVTVAAGDREGNRASYSNYGSIVDITAPGGETAAGSANGILSTLNSSTTTPGSETYRAYQGTSMAAPHIAGLAALMYEKDPALTPSAVEAALKNNARALPGSCSGGCGHGLADAARTLDALGGGGTDPGGQVFTNSENWNIPDADGRYVYSNITVSGISGYAPSDLKVSVDIKHTYRGDLKVQLFAPDGTSWTLKNTSSSDSADHVVATYTVNASSVPASGTWQLRVTDVYSGDTGYIDSWSLTF

Crispr_ID: NZ_CP022310_7

• CRISPR_ID: NZ_CP022310_7
• CRISPR_location: 3286848-3286954
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_7

Consensus_repeat	Method
CCGCTGGACCGGTGCGGCCTGCCG	CRISPRCasFinder

spacers of NZ_CP022310_7

>7.1|3286872|59|NZ_CP022310|CRISPRCasFinder
GCCGAGGTGGCCGGGACGGCGGGAGTTCGGGACCGAGCACGGCCTGCCGGCCGGGTGGC

CRISPR arrays and Neighbor proteins around NZ_CP022310_7

CRISPR arrays

The CRISPR arrays of NZ_CP022310_7

>merge|NZ_CP022310|7|3286848-3286954|CRISPRCasFinder
CCGCTGGACCGGTGCGGCCTGCCGGCCGAGGTGGCCGGGACGGCGGGAGTTCGGGACCGAGCACGGCCTGCCGGCCGGGTGGCCGCTGGACCAGGTGCGGCCTGCCG

>NZ_CP022310|7|5|3286848-3286954|CRISPRCasFinder
CCGCTGGACCGGTGCGGCCTGCCG	GCCGAGGTGGCCGGGACGGCGGGAGTTCGGGACCGAGCACGGCCTGCCGGCCGGGTGGC
CGCTGGACCAGGTGCGGCCTGCCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142194577.1|3283617_3284166_-|YbjN-domain-containing-protein	unknown	unknown	gnl|CDD|371210
NZ_CP022310.1|WP_142194582.1|3280395_3280818_+|PIN-domain-containing-protein	unknown	unknown	gnl|CDD|350322
NZ_CP022310.1|WP_142232154.1|3280859_3281633_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|181382
NZ_CP022310.1|WP_161175074.1|3288836_3290243_+|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NZ_CP022310.1|WP_142194571.1|3291494_3292079_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP022310.1|WP_142232159.1|3292277_3292754_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647
NZ_CP022310.1|WP_142232156.1|3283106_3283604_+|DUF2975-domain-containing-protein	unknown	unknown	gnl|CDD|378586
NZ_CP022310.1|WP_142232152.1|3279156_3280086_+|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP022310.1|WP_142232157.1|3287233_3288322_+|glycoside-hydrolase	unknown	unknown	gnl|CDD|366353
NZ_CP022310.1|WP_142232158.1|3290809_3291415_-|hypothetical-protein	unknown	unknown	gnl|CDD|237855
NZ_CP022310.1|WP_142232160.1|3294822_3295659_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223472
NZ_CP022310.1|WP_161175080.1|3290347_3290680_-|DUF2516-family-protein	unknown	unknown	gnl|CDD|378483
NZ_CP022310.1|WP_142232161.1|3295655_3296663_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|224096
NZ_CP022310.1|WP_142232155.1|3282259_3283075_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225117
NZ_CP022310.1|WP_142232153.1|3280183_3280399_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl|CDD|378324
NZ_CP022310.1|WP_142194575.1|3285825_3286617_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	unknown
NZ_CP022310.1|WP_142194576.1|3284158_3285496_-|D-inositol-3-phosphate-glycosyltransferase	unknown	unknown	gnl|CDD|132490
NZ_CP022310.1|WP_142194569.1|3294215_3294833_+|DUF664-domain-containing-protein	unknown	unknown	gnl|CDD|368218
NZ_CP022310.1|WP_142234118.1|3292918_3294127_+|MFS-transporter	unknown	unknown	gnl|CDD|340882
NZ_CP022310.1|WP_142194580.1|3281792_3282209_-|DUF2000-family-protein	unknown	unknown	gnl|CDD|378176

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142194577.1|3283617_3284166_-|YbjN-domain-containing-protein	gnl|CDD|371210	pfam10722, YbjN, Putative bacterial sensory transduction regulator. YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabilizer for some other unstable proteins. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	5.4474e-18
NZ_CP022310.1|WP_142194582.1|3280395_3280818_+|PIN-domain-containing-protein	gnl|CDD|350322	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC3 and VapC21 toxins. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.16333e-56
NZ_CP022310.1|WP_142232154.1|3280859_3281633_+|methyltransferase-domain-containing-protein	gnl|CDD|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	4.57693e-56
NZ_CP022310.1|WP_142232160.1|3294822_3295659_-|ABC-transporter-permease-subunit	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.24595e-81
NZ_CP022310.1|WP_142194571.1|3291494_3292079_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.14411e-15
NZ_CP022310.1|WP_142194569.1|3294215_3294833_+|DUF664-domain-containing-protein	gnl|CDD|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	1.35231e-42
NZ_CP022310.1|WP_142194576.1|3284158_3285496_-|D-inositol-3-phosphate-glycosyltransferase	gnl|CDD|132490	TIGR03449, mycothiol_MshA, D-inositol-3-phosphate glycosyltransferase. Members of this protein family, found exclusively in the Actinobacteria, are MshA, the glycosyltransferase of mycothiol biosynthesis. Mycothiol replaces glutathione in these species.	0
NZ_CP022310.1|WP_161175074.1|3288836_3290243_+|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.58724e-38
NZ_CP022310.1|WP_142232152.1|3279156_3280086_+|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000122773
NZ_CP022310.1|WP_142232158.1|3290809_3291415_-|hypothetical-protein	gnl|CDD|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	0.00156997
NZ_CP022310.1|WP_142232159.1|3292277_3292754_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	7.7098e-31
NZ_CP022310.1|WP_142232161.1|3295655_3296663_-|ABC-transporter-permease-subunit	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	7.82593e-83
NZ_CP022310.1|WP_142232155.1|3282259_3283075_+|helix-turn-helix-domain-containing-protein	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.69669e-20
NZ_CP022310.1|WP_142232156.1|3283106_3283604_+|DUF2975-domain-containing-protein	gnl|CDD|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	5.07094e-15
NZ_CP022310.1|WP_142232153.1|3280183_3280399_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl|CDD|378324	pfam09957, VapB_antitoxin, Bacterial antitoxin of type II TA system, VapB. VapB is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is VapC, pfam05016. The family contains several related antitoxins from Cyanobacteria and Actinobacterial families. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the Toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all antitoxins.	7.58101e-06
NZ_CP022310.1|WP_161175080.1|3290347_3290680_-|DUF2516-family-protein	gnl|CDD|378483	pfam10724, DUF2516, Protein of unknown function (DUF2516). This family is conserved in Actinobacteria. The function is not known.	1.84575e-31
NZ_CP022310.1|WP_142194580.1|3281792_3282209_-|DUF2000-family-protein	gnl|CDD|378176	pfam09391, DUF2000, Protein of unknown function (DUF2000). This is a family of proteins of unknown function. The structure of one of the proteins in this family has been shown to adopt an alpha beta fold.	5.93521e-60
NZ_CP022310.1|WP_142234118.1|3292918_3294127_+|MFS-transporter	gnl|CDD|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.04541e-56
NZ_CP022310.1|WP_142232157.1|3287233_3288322_+|glycoside-hydrolase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.56892e-22

Protein sequences

>NZ_CP022310.1|WP_142194575.1|3285825_3286617_+|class-I-SAM-dependent-methyltransferase
MGTVTRGTTNPNRLRRMDRWIAATHGAELRRAADPLAVDLGYGAAPWTAVELLHRLRSTAPRTRVTGVEIEPARVAAARPYEREGLAFRHGGFEIPLPGRPLLIRAANVLRQYDETEVAAVWRRLCARLAPADPETGSRGGLLVEGTCDEIGRRHVWVALGPEGPRTVSFATRLGSLERPSDLAERLPKALIHRNVPGEPVHAFLRDFDRAWAAAAPYASYGARQRWIRTVRDLTADWPVTDGPNRWRQGEVTVRWEALAPRG
>NZ_CP022310.1|WP_142194576.1|3284158_3285496_-|D-inositol-3-phosphate-glycosyltransferase
MSQYIARLGRRSPAVPPRLRMHRRPRRVAMLSVHTSPLHQPGTGDAGGMNVYIVELAQRLAAINIEVEIFTRATSASLPPTVDLAPGVLVRHVDAGPYEGLAKEDLPAQLCAFTHGVMQAWAGHRPGHYDLVHSHYWLSGHVGWLAAQRWGVPLVHAMHTMAKVKNANLADGDTPEPAARVIGETQIVAAADRLIANTAEEADELVRHYDADPGKVAVVHPGVNLSRFRPADGRAAARARLGLPRDALIPLFAGRIQPLKAPDILLRAVAVLLDERPELRSRICVPVVGGPSGSGLAKPEGLQKLAARLGIADVVRFRPPVGQEQLADWFRAASVLVMPSYSESFGLVAIEAQAAGTPVLAAAVGGLPVAVRDGHTGFLVQGHDPAAYARVLRDFADHPHLADRMGEAAARHAQSFGWGTAAAATADVYTAATHAHRRHVRSHHG
>NZ_CP022310.1|WP_142194577.1|3283617_3284166_-|YbjN-domain-containing-protein
MADKAADAADPGQRAARVIEDVLKDAELEWESTAPGSYVVKLPGTRKLSTTVSLIAGRHTLSLNAFVIRHPDENEAAVHRWLLERNLKLFGVSYAVDPLGDIYVTGRLPLSAVTAEEVDRLLGQVLEAADGSFNTLLELGFASAIRKEYAWRVSRGEPTRNLDAFAHLLARPSEQAEDPARD
>NZ_CP022310.1|WP_142232156.1|3283106_3283604_+|DUF2975-domain-containing-protein
MSRVLVTVLRAGIVAAFVLGLFAQIVVVPATAAGEVDAFPPYAPLQVPYGTAAIAGVGCVQVALVAVWRLLTLAERDAIFTPRALWWVDTVIGALVVETVLALVVGGHLAVTEIPSPDDGMDVVGALGAALVTVGVGASFALLVVVLRQLPQKAARLQAERAGAV
>NZ_CP022310.1|WP_142232155.1|3282259_3283075_+|helix-turn-helix-domain-containing-protein
MASQGKVSAWRPRVPGVVEVFHAHFTEYAYPMHVHDAWTLLIVDDGAVRYDLDRHEHGTPHDTVSLLPPHVPHNGSPATPDGFRKRVLYLDGSRLGDDLIGAAVDRPDLRDPLLRRRVAQVHSALARPGDELEAESRLTLVGERLREHLRSRDVTAVPRRDPVLARRLRELLDARVVEGLTLEEAGTLLSAHPAHLVRAFSSAYGIAPHQYLMSRRVGRARRLLLEGRSPSGVAVATGFYDQAHLTRHFRKLVGITPGRYRSSGHHPHGTY
>NZ_CP022310.1|WP_142194580.1|3281792_3282209_-|DUF2000-family-protein
MSTRFDTKIAVLLREDLETWQRLNVTAFLVSGLGTQLPEVIGEPYEDADQVPYLPMFRQPVLVFQGTKETLRAAHTRALSRALPRAVFTSDLFATGHDEANRAAVRAVGTADLDLVGLSVYGPKNAVDKVLKGAHMHP
>NZ_CP022310.1|WP_142232154.1|3280859_3281633_+|methyltransferase-domain-containing-protein
MSSTLGVPQPDQASYMLRAAATDAGRAYKRRLLELLDVRAGQTVLDVGCGPGTDLAALAERVGDRGSVIGVDRDAAMLAQARARTEGLPRVELREGDAHALPVESDSVDRAKIDRVLMHVAEPADVLAELRRATRPDARIGLAEPDWDTLVVDSDDLGTSRAFTRYTTAEVVRHATIGRSLARLAERAGFRVEAVDAVTPVFLDFREADHTLGLGRNLRKAIDGGHIDQARGRDWFAGLQQTPFYASFTLVSVVCAR
>NZ_CP022310.1|WP_142194582.1|3280395_3280818_+|PIN-domain-containing-protein
MNAALFLIDTSALARLLRGDAEQFGWDRAVAAGLIATCPVTELEFFYSARSAADRAQGIEDLRSLFGWVPVDDRAYERAWQVQEMLTQRGQHRSAGAVDLVVAATAELQGLTLLHRDRDFECIAAVTGQALQWYGPEVGK
>NZ_CP022310.1|WP_142232153.1|3280183_3280399_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MSRTVIDLDDELVADVAKALGTSTKRETVNSALREVLEYRRRALALTRLRAAAEDGAFDLDLFEDKGNYRR
>NZ_CP022310.1|WP_142232152.1|3279156_3280086_+|hypothetical-protein
MADPQSNARLRADAGAPTSGVIHVRTRLTADFTVISNALAQRRGSAVTVGVAVYILSLPDGTPVSIAALCEHFTEGEILISRALRELEAAGYLERRRVRLPTGQIRTRTYFHDVPDRAPHTAPAPGQDPHPTAAPDPETTTDAAQVEAPAPSEGPDMSEAPAPSEGPDMRSPVADTPVPLADAEPEAVAVLAALRRVDRRLVLSVGEAARLAPAVSQWLAAGVDAVEITKLLTASLPDRLRARPAGILAFRLRETPLPAPPMPLPTARAERPAAVLPFQTCDGCDRAFRAPGPGQCRDCRSGNGLRAAG
>NZ_CP022310.1|WP_142232157.1|3287233_3288322_+|glycoside-hydrolase
MGKGKRGLVTAAVTVVCAVTVLAVPGTAFAAPAPPPAPSPSPGVSVPADKDLEAVREKLDELYRAAAVATDAYNAADEKARLQSAQVAKLTRKIAKGQERLDELRARAGAAAAAQYRGGGLPPEAHLMLSDDPQDFLDGADRVRQGQHATNGLLGELTRTQQDLEQYARDADAQLKKLQAGRKAKAKAQQRIEKRIEAAEKLESQLEDEEKERLARLQQQAADRAQSAWLSSGILDEISGKATKQGKEAVAYATAQIGKPYQWGAEGPRTYDCSGLTSQAWLSAGQGIPRTSQAQWKQLERVDIRGMRPGDLIIYFDDASHVGMYVGDGVMVHAPRPGRNVTLAGAGSMPILGVVRPDPDTN
>NZ_CP022310.1|WP_161175074.1|3288836_3290243_+|SpoIIE-family-protein-phosphatase
MPVPVPRQRAIPAAEGGQAPAASLDGGPAQDSSEARTAVPHATDPHTTDPSGNATDRSGTSPDRTGTTPERAGTATPTNLTLLLIENDPGGSPIVPDLLDQSGKPIRVRTARNLTEAERLLTDDVHCILLDLALPAPGRDGDADELAVLKHVLELAPRHAVLALTGADDTERGAEAVRVGAQDYLVRDELDGRLLGRAIRYAVERKRSESAERRLAEGRLRAQENRRLERGLLPTPLLEGSSLRFAARYRPGRSRALLGGDFYDVVRTPDGTVHAMIGDVCGHGPDEAALGVELRIAWRALTLAGLCGDQLLSTLQQVLEHERADDEIFATLCTVDIAPDGRRAGLCLAGHPSPLLARPGLPARLLPYDNNGPALGLLPGARWPRMQVELGAEWSLMLYTDGLIEGRVGDTGERLGQDGMVGMIRRQLDEGLRGEELLRTAVNEVRHLNGGELTDDVAVLLLDRVRTA
>NZ_CP022310.1|WP_161175080.1|3290347_3290680_-|DUF2516-family-protein
MQGFNSFMSLLNLALVVFSGFALIDAATRREDAYRAADKQTKPFWLIILGIAFVVALIFEILSFLPIIGLIATIVYMVDVRPALRGLPGGGRARRGSSSDGPYGPWNGGR
>NZ_CP022310.1|WP_142232158.1|3290809_3291415_-|hypothetical-protein
MAITDDLRKTFSDPTPLYFAAGTADLALQQAKKVPALVEQLRAEAPARIEAVRNTDPKAVQERATTRVRETQETLQTKVGELLGTLDTDLKKLGETAQDLALRGVGVAAEYAVKARETYEKVAEHGEQAVRTWRGDAAEGIEDIAVAVEPPAVPKPASEPVETADGKQADGKPAAEGRPAPAKKAPARKATTQKKTTPPAK
>NZ_CP022310.1|WP_142194571.1|3291494_3292079_-|helix-turn-helix-domain-containing-protein
MASLNVGNLGEYLREQRRSAQLSLRQLADAAGVSNPYLSQIERGLRKPSAEVLQQVAKALRISAETLYVRAGILDAERELDEVETRAVILADPTLTERQKQVLLQIYESFRKENGFGAAGDGQVTDGDREVTSADDVAGPDGVSGTADGSGGEPDAPVDGAAVRRTRTADGGRTARRRTRAADGSDTDPPRTAG
>NZ_CP022310.1|WP_142232159.1|3292277_3292754_-|helix-turn-helix-transcriptional-regulator
MVSRTRFDDSECPVARSVDAIGDWWSLLIVRDAFDGSRRFGEFQRSLGVARNILTARLRALVAGGVLETVPASDGSAYREYVLTPKGQALFPVIVALRQWGEQNFFDPGEPHSELVDRRQGRRLRPLEVLAEDGRRLSPDDTTVRKVSPSAATSRESG
>NZ_CP022310.1|WP_142234118.1|3292918_3294127_+|MFS-transporter
MLSRGVVVLFAVACGTAVANVYFAQPLLVTMGHDLAMSPALVGSVVTLTHVGYGLGLFLLVPLGDVTDRKRLVVAQLLLLVAALTVVAAAPTAATLLVGMAATGLLAVVTQTLVAFAASLAPAAARGRVVGAVTSGVVTGILLARTVSGLVADLAGWRSVYLLSASLTALLALVLHRVLPRHGGTPPTPLRYGQLLRSTITLFARERLLRLRALFALLVFAAFSTLWSSVALPLSEAPYFLSHSAIGALGLIGVAGALAASVAGRLNDRGLSGRTTGVALALLTASWVPLAFTRSSLWALCVGVVLLDLAVQAVHVTNQTLIHALHPDAGSRLIGGYMVFYSVGSATGALAATSLYTVAGWGAVCALGAAFSCLGLLLWTFTRRGVPAPATGTAPPGTAHGR
>NZ_CP022310.1|WP_142194569.1|3294215_3294833_+|DUF664-domain-containing-protein
MTASGTKSDLRFYLQSARDALLWKLDGVAEYDVRRPLTPTGTNLLGLVKHAAGVELGYLGDVFGRPHGDPLPWLADGAEPNGDMWATADESRESVVALYRRAWAHADATIEALPLETVGRVPWWQDGKDEVTLHHAVVRVIADTQRHAGHADVLRELMDGAVGMREDNTALPSSDPAWWEAYRERLEGAARQAAEREGGRPAVSP
>NZ_CP022310.1|WP_142232160.1|3294822_3295659_-|ABC-transporter-permease-subunit
MIGKETKAGRAAKFTFLGLWLVFSLFPLYWITVTSLKASGDIFSFPISYWPERFSLENYQGLFGKADFGTYLVNSLVVATVAGAVATAISTLSAYVLARFEFRSKSALLMAALVTQMIPSFIALGPLYLLMTDLRLVDNRLGLVLVYIAVCIPFCTVMLRGFFENVPDALEEAAMIDGLSRLGALLRVLLPVMRPGIVAAFIFNFVNCWNELFLSVTLMNSDANKTVPTALNGFISSFNIDWGSMSAAAVLTILPTMVLFAFASRHIVQGLTSGAVKG
>NZ_CP022310.1|WP_142232161.1|3295655_3296663_-|ABC-transporter-permease-subunit
MSTTSRPNARTAPSVRKEGAPPGRGTAGGRRRREFTTRRGLVIAAFMAPAAVFVAVFTYYPMIAGSQMAFRNWNLTDLTDTSWVGWKNFTEVFTDPAWSTVVDNTLLWVVGSIVPQLVIGFAIALWLRRRFRFRGLYQALIFFPWAISGFLIGILFRWLFNSEFGVVNDLLQKAGLIDEPVAWLADPQTAMTAVLIANVWYGVTFFAIMILAALQSIPDELYEAAALDGAGKARTLFRITIPYIRVTLALTVLLRVIWIFNFPDLIFGMTGGGPNDETHIVTTWMIKITQQGDYGKASALGLLVVAVLLVFAVFFLLATRERRGGRGTRERGARA

Crispr_ID: NZ_CP022310_8

• CRISPR_ID: NZ_CP022310_8
• CRISPR_location: 3446304-3446371
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_8

Consensus_repeat	Method
TCTCCCCGCGCTCCGGACTCCGC	CRISPRCasFinder

spacers of NZ_CP022310_8

>8.1|3446327|22|NZ_CP022310|CRISPRCasFinder
TCCAGCCATCTCCCCGGGCTCC

CRISPR arrays and Neighbor proteins around NZ_CP022310_8

CRISPR arrays

The CRISPR arrays of NZ_CP022310_8

>merge|NZ_CP022310|8|3446304-3446371|CRISPRCasFinder
TCTCCCCGCGCTCCGGACTCCGCTCCAGCCATCTCCCCGGGCTCCGGTCTCCGGGCTCCGGGCTCCGG

>NZ_CP022310|8|6|3446304-3446371|CRISPRCasFinder
TCTCCCCGCGCTCCGGACTCCGC	TCCAGCCATCTCCCCGGGCTCC
GGTCTCCGGGCTCCGGGCTCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142194466.1|3444885_3446172_-|phosphoribosylamine--glycine-ligase	unknown	unknown	gnl|CDD|234856
NZ_CP022310.1|WP_142232225.1|3440922_3442479_-|phosphoribosylamine--glycine-ligase	unknown	unknown	unknown
NZ_CP022310.1|WP_142234122.1|3449858_3451607_-|transporter	unknown	unknown	gnl|CDD|377255
NZ_CP022310.1|WP_142194470.1|3439113_3439734_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_CP022310.1|WP_142194454.1|3458391_3459000_+|LytR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379163
NZ_CP022310.1|WP_142234123.1|3455999_3456722_+|SIP-domain-containing-protein	unknown	unknown	gnl|CDD|99790
NZ_CP022310.1|WP_142232221.1|3434506_3434770_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS	unknown	unknown	gnl|CDD|235659
NZ_CP022310.1|WP_142194414.1|3459094_3459730_-|uracil-phosphoribosyltransferase	unknown	unknown	gnl|CDD|234653
NZ_CP022310.1|WP_142232226.1|3442710_3444591_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP022310.1|WP_142232230.1|3456746_3457349_+|Fe-S-cluster-assembly-protein-HesB	unknown	unknown	gnl|CDD|132296
NZ_CP022310.1|WP_142232229.1|3452992_3455923_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|376618
NZ_CP022310.1|WP_142232228.1|3451749_3452520_-|glucose-1-dehydrogenase	unknown	unknown	gnl|CDD|235500
NZ_CP022310.1|WP_142194418.1|3452516_3452996_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380376
NZ_CP022310.1|WP_142232222.1|3436089_3437052_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_CP022310.1|WP_004943146.1|3457924_3458221_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl|CDD|227737
NZ_CP022310.1|WP_142194472.1|3437048_3437825_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223912
NZ_CP022310.1|WP_142232227.1|3449189_3449762_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|239217
NZ_CP022310.1|WP_142232224.1|3439933_3440833_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl|CDD|237571
NZ_CP022310.1|WP_142194474.1|3435123_3435441_+|Lsr2-family-protein	unknown	unknown	gnl|CDD|378714
NZ_CP022310.1|WP_142232223.1|3437854_3439117_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142194466.1|3444885_3446172_-|phosphoribosylamine--glycine-ligase	gnl|CDD|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	0
NZ_CP022310.1|WP_142232224.1|3439933_3440833_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl|CDD|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	0
NZ_CP022310.1|WP_142232230.1|3456746_3457349_+|Fe-S-cluster-assembly-protein-HesB	gnl|CDD|132296	TIGR03252, TIGR03252, uncharacterized HhH-GPD family protein. This model describes a small, well-conserved bacterial protein family. Its sequence largely consists of a domain, HhH-GPD, found in a variety of related base excision DNA repair enzymes (see pfam00730). [DNA metabolism, DNA replication, recombination, and repair].	6.5304e-99
NZ_CP022310.1|WP_142194470.1|3439113_3439734_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.72488e-60
NZ_CP022310.1|WP_142194454.1|3458391_3459000_+|LytR-family-transcriptional-regulator	gnl|CDD|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	6.53329e-14
NZ_CP022310.1|WP_142234123.1|3455999_3456722_+|SIP-domain-containing-protein	gnl|CDD|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	8.25318e-46
NZ_CP022310.1|WP_142232221.1|3434506_3434770_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS	gnl|CDD|235659	PRK05974, PRK05974, phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed.	1.16972e-39
NZ_CP022310.1|WP_142194414.1|3459094_3459730_-|uracil-phosphoribosyltransferase	gnl|CDD|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	3.98521e-116
NZ_CP022310.1|WP_142232226.1|3442710_3444591_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	3.94288e-08
NZ_CP022310.1|WP_142232229.1|3452992_3455923_-|GNAT-family-N-acetyltransferase	gnl|CDD|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	3.9991e-162
NZ_CP022310.1|WP_142232228.1|3451749_3452520_-|glucose-1-dehydrogenase	gnl|CDD|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	7.64664e-80
NZ_CP022310.1|WP_142194418.1|3452516_3452996_-|cupin-domain-containing-protein	gnl|CDD|380376	cd06121, cupin_YML079wp, Saccharomyces cerevisiae YML079wp and related proteins, cupin domain. This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.	4.14252e-64
NZ_CP022310.1|WP_142232222.1|3436089_3437052_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.05391e-91
NZ_CP022310.1|WP_004943146.1|3457924_3458221_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl|CDD|227737	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription].	7.97587e-08
NZ_CP022310.1|WP_142194472.1|3437048_3437825_+|ABC-transporter-permease	gnl|CDD|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	3.55582e-10
NZ_CP022310.1|WP_142232227.1|3449189_3449762_+|NUDIX-domain-containing-protein	gnl|CDD|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	1.08722e-13
NZ_CP022310.1|WP_142234122.1|3449858_3451607_-|transporter	gnl|CDD|377255	pfam04234, CopC, CopC domain. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm.	1.8627e-24
NZ_CP022310.1|WP_142194474.1|3435123_3435441_+|Lsr2-family-protein	gnl|CDD|378714	pfam11774, Lsr2, Lsr2. Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes. It is a functional homolog of the H-NS-like proteins. H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression.	1.88619e-47
NZ_CP022310.1|WP_142232223.1|3437854_3439117_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.40023e-37

Protein sequences

>NZ_CP022310.1|WP_142194466.1|3444885_3446172_-|phosphoribosylamine--glycine-ligase
MKVLVIGSGAREHALCHSLSLDPDVTALHCAPGNAGIAEVAELHPVDALDGAAVSELARRLGADLVVVGPEAPLVAGVADAVRDAGIPVFGPSKEAARLEGSKAFAKEVMAGAGVPTARSYVCTTPEEVDAALNAFGAPYVVKDDGLAAGKGVVVTGDVEAARAHAAACIGESPAPSGQQGRVVIEEFLDGPEVSLFAITDGETVVPLQPAQDFKRALDGDEGPNTGGMGAYSPLPWADPKLVDEVMETVLQPTVDELRRRGTPFSGLLYAGLAITSRGVRVIEFNARFGDPETQVVLARLKTPLGGVLMAAATGNLAHLEPMRWSDEAAVTVVVASHNYPGTPRTGDPITGLDEIAAQDAPHAYVLHAGTRREGDAVVSAGGRVLSVTATGKDLTEARDRAYRAVSRIGLDGSQHRTDIAAQAARDA
>NZ_CP022310.1|WP_142232226.1|3442710_3444591_-|hypothetical-protein
MSGSGMGAEAGARAARARALAVLRIRSRALAVALLPAAVAVVLLVGGSTGRLPGAGWDLARRIVVPVAVLVLLVAAGVALVVARARPAVSPTVPVTEEAAPDLYRMVRDLADRLEVPAPSAIALTPDCDSWLEDRTHPAHGPPPAEESGGRAGAGPSARVRVDAAPVLVIGSPFLWWMRVGELRAVLAPVVAGTGPSAHPDIAAARRFVRGLDAAVAETSAPRRGPVFRGVLAGVGWIVRLLLRGCRVHAAEMERGVAAAAAERAQAVDYGLRIVAQEQVGLAYAGWDRLLTRVALPAWRMGRWPSRLNAGVVAALTELSRRDRLAEGFASRLGERPACDLLEEPGAVDEAASLLAARLFHGGPAQTGPAWSPVGWVGYPEEVVDRKWRTDAARLHRVLDALRVPPGAADPTAPHAPTLTRVLDHLTTTPPAPAATRTGAQAPATPPAPAEPAALAAPAPAAPAIGDEPPAPHDGALTPDGGPLTPYDEDLVGTTARSAALAARLSAELAREEAAASATAGPGAGPDPAPLRDDEALPLFPLQPPRTARELLADHITAMVCCAAMDTVGAAPGLDWLDGPTLLLGGERAADLSPQVLTLIEDGDPSALRRWLTRQGIRAEKPVRLG
>NZ_CP022310.1|WP_142232225.1|3440922_3442479_-|phosphoribosylamine--glycine-ligase
MGSEQIRRWESGALAHAVNDPFGQGPLPWLRGGETYFGDSGQVVPWYVDPDPYANPHADPTTDPGRSAARPPGPRSPGHGTHGIPAARSSGGPRAADDVHRQIKGFASTGGVAPGDSIDFHITVDPPQEFGVDIYRIGHYGGHGATHITSSPRLSGIVQPAPLTADRTVSCHHWWLSWRLPVPSYWSVGAYVAVLTTADGYRSHIPFTVRDDRPADLLLVLPDVTWQAYNLYPEDGRTGASLYHAWDEEGRLLGEADAATTVSFDRPYAGAGLPLHVGHAYDVIRWAERYGYDLAYADARDLHAGRVDPTRYRGLIFPGHDEYWSAPMRTAAEHARDHGTSLVFLSANTLYWQVELAPSPSGPDRLLTCRKRRGPGKPVLWREIDRAEQQLLGIQYAGPVPEPHPLIVRNADHWMWEATGAHEGDHIAGLVAGEADRYYPRTPLPEYEERVLLAHSPYTDRDGSRRHQETSLYRAPSGAWVFASGTFAWSPALDRPGHVDPRIQRATANLLDRICKRD
>NZ_CP022310.1|WP_142232224.1|3439933_3440833_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MSGFVEKPEPIQVPGLVHLHTGKVRELYRNEAGDLVMVASDRISAYDWVLPTEIPDKGRVLTQLSLWWFDQLADLLPHHVLSTDLPAGAPADWAGRTLVCKSLNMVPVECVARGYLTGSGLAEYNESRTVCGLALPEGLVDGSELPAPIFTPATKAAVGEHDENVSYEEVARQVGAETAAQLRQATLAAYSRARDIARERGILLADTKFEFGFDGETLVIADEVLTPDSSRFWPAEQWEPGRAQPSYDKQFVRDWLTSAESGWDRRSEQPPPPLPQQVVDATRAKYVEAYERLTGTVWS
>NZ_CP022310.1|WP_142194470.1|3439113_3439734_+|response-regulator
MTSTRPVRLLLADDEHLIRGALAALLSLEDDLTVVAEAASGPEALAMARAHAPDVAVLDLQMPGADGVKVATSLRAELPGCRVLIVTSHGRPGHLKRALAAGVRGFVPKTVSAQRLAEIIRTVHEGNRYVDPELAADAIASGDSPLTAREAEVLELAADGAPVAEIAERAALSQGTVRNYLSSAVSKLGAENRHAAVRLARERGWV
>NZ_CP022310.1|WP_142232223.1|3437854_3439117_+|sensor-histidine-kinase
MNRPGGWWGRKSTPAKVETYTRWSFHLIALIEFMVVCGPVIEHAASRSAALLLALTLVHSVGCAVTASRALDWLRGQRERPSRTLWLFGVVTAVVAVVALLVIEHGPGGKDGAGAAGAVFAIVTAFGTGVLALGVRGRRSVLLTVAGFALGAGTVSLLLGRPAVVALLVTLVVLAGGGFSAFTSLFSVWLLNAVYELDEARETRARLAVAEERLRFGRDLHDVMGRNLAVIALKSELAVQLAQRERPEAVTEMIEVQRLAHEAQREVREVVRGYREADLAGELAGAHGVLTAAGIDCTVTGPTGGLPAPVQSALGWVVREAATNVLRHGDARRCAMTLTVREGRVVLTVENDGVPQSSGSGRGSGLVGLRERLAEIGGTLRAGPVGDGSFLLTVDIPLPSHSGEAHPAVHTRLYVSEATP
>NZ_CP022310.1|WP_142194472.1|3437048_3437825_+|ABC-transporter-permease
MSTTTTTPVSRMTSLARAELTLLGRSKGTLFAALFVPLVLPLSVRSAAEEMDLAEAGLTPGTVVLPAAVGFSLLFAVYSALVGVFVVRREELVLKRLRTGELRDGEILGGSALPAALVGLAQCLLLAAGCTALLDLPAPSAPHLAVLGLLLGIAMCAALAAVTASFTRTGESAQVTPMPLMIVSMLGSGMFVPLELLPDRLASFCELLPLTPVVTLVRGGWTGDLSAYETLGTVATAVAWTLLAVFAVQRWFRWEPRR
>NZ_CP022310.1|WP_142232222.1|3436089_3437052_+|ATP-binding-cassette-domain-containing-protein
MEANEHEHVIEVTDLRRVYGGGFEAVRGIDFSVRRGEIFALLGTNGAGKTSTVELLEGLAAPAGGRVRVLGHDPYTERAAVRPRTGVMLQEGGFPSELTVAETARMWAGCVSGARPVPDVLGLVGLEAKAGVRVKQLSGGQRRRLDLALALLGDPEVLFLDEPTTGLDAEGRRDTWELVSALRDGGTTVVLTTHYLEEAENLADRLAIMHDGRIAVTGTPAEVTATEPSRITFELPHGYFVGDLPPLGELGVSDHLVDGRTVRLRTRELQRAATGLLVWAQTAGVELRRLDVRSASLEEAFLGIAKDVTAGTGAAKEYAA
>NZ_CP022310.1|WP_142194474.1|3435123_3435441_+|Lsr2-family-protein
MAQKVVVTLFDDIDGSEAAETIAFGLDGKSYEIDLNEANARKLRTALAPYVDAGRKRSRSGRTYRQTEVAPDPAAVRAWAQANRMDVPARGRIPKKVYEAFAAAQ
>NZ_CP022310.1|WP_142232221.1|3434506_3434770_-|phosphoribosylformylglycinamidine-synthase-subunit-PurS
MARVVVDVMLKPEILDPQGQAVQRALPRLGFEGISDVRQGKRFELEVDGPVDEAALARINDLAESFLANTVIEDFTVRVEEVTEAAK
>NZ_CP022310.1|WP_142232227.1|3449189_3449762_+|NUDIX-domain-containing-protein
MSRAITRAGGHHVEVVAPDSPPLAVDDRGNALVTFVRGAEDKPPGDAPLPVALVALWHGSRVLMAFNRFRQAWELPGGRIDTGETARQAAVRELLEETSHVPHGQLCFVGFAGFTLAPDERAEYGALFTGQVADVSPLFRPNDEIAAIRWWDLRESLPGRLQPLDAHLAELSRNALTSTRHGTALGCRTS
>NZ_CP022310.1|WP_142234122.1|3449858_3451607_-|transporter
MLLAAALVALLLGGAAPALAHSALRDTDPADQSVVDTPPRHITLTFTESVGLLEDSFRVYGPDNRRVPLGEPRHAPGASDTARTALPGGLADGTYTVAWRVVSADSHPVSGAFTFSVGRPSPTPPAVPATADEHPVTASLYDTGRHLAYVAAALLIGTAAFAALCRPPDTAPLWPALLTGWWTLLTATVVLLVLRAPYEAGTAPGTALDASAAARTLTGRPGLALLARLALLLLTAAALLLLRRSRRGRAPETDRTPPAHLAVGAALAVALALTWAAAEHASAGLQVPSAMTSSVLHLLAMACWLGGLTALLLTLYRARTPPPPATVTRFSRLAFLSVTVLVVTGVYQSWRGLGSWNALTDSSYGRVLTLKLLATALLLSAAALSRHWTTALATAPAEPHPPTGTTTPPAPLPTAAVDGHRRALRRSVLAEAAVAVVVLLITTVLTGTLPARAESEAAESPRPQVAGLPGASAFTIPFDVGTPDGRGTVQITMDPGRVGENGVQAVVFGPDGGLTAVPELRLTFTLAAEDIGPLDVQLTDRGGYWATNDLNLPLAGTWTMRLTVRTSALDQVTETRPIRITR
>NZ_CP022310.1|WP_142232228.1|3451749_3452520_-|glucose-1-dehydrogenase
MSGRGLLEGQVALVTGAGGGIGRGIAERFAEEGAAVALHCRTSVESARDTADRIRAAGGEAVVLHADLTDEDACHRLVAEAAEWGGGRLTALVNNAGVQPVQELAGMTAAEWRTVVDTNLTGVFACTQAAARLMRDGDGGTVTHIASVEARSPAPAHAHYCASKAAVVMHARSAAQEYGPWGVRVNTVSPGLIDREGLADAWPEGVRRWQQASAVGRLGRPEDVGDACVFLASPLASWITGHDLLVDGGASARPTW
>NZ_CP022310.1|WP_142194418.1|3452516_3452996_-|cupin-domain-containing-protein
MTPEEIVAHYGLEPIPQEGGRFRQTWAGPERPDGRPEGTAIVVLLTSAPGDFSALHRLPTDEVWHHYLGDPLEFLLLAPDGTSRTPVLGPDILGGQHVQLTIPAGTWMAARVVAGGDWTLFGCTMAPGFTYGGYEHGDPVELAARYPDRAAQIAELGRP
>NZ_CP022310.1|WP_142232229.1|3452992_3455923_-|GNAT-family-N-acetyltransferase
MAGEIFRDPWGIPHLRADSARDLAYVQGRVTALDRAWQLEVERHRAQGTSAAFLGPEALSWDCFVRRARLADTARRCWSELERTDPETAAWLRAYVDGVNEGLASGPVPTPDAPTEPAPAPEFARTGLRPGRWEPWTPLAVWLATHILFAGFPAKLWREHAVAHLGADAVGLFATDGPGTAGSNGWLVAGGRTVTGQALIAGDPHRFIEDPGVYQQIRLSCPEFDVIGLAVPGVPGIAHFGHTGTVAWAITNAMADYQDLYRERLRRTGAGVEALGPDGTWRRAARHTETVEVAGEQPVEVEVIETDRGPVVIGGPEGLDGGLPEPGAPPVAISLRHPPRVTGDLGFGALLPLLRARRVADVDAAVDRWVEPVNVVLAADTEGGTLHRVAGRVPVRSAANRTRLVAAWEPGHAWQGWHEPPRAGLTDGVAVMANQRGPATPLGVEFAPPHRADRIAALLAGRERWSAADLSAIHTDTHLASAAALLDRLAALDGLSGPAAALRDRLLRWDRRMDADSADAAAFAAVRGAVVRRLAAHPAFAALRTPPAYPAVFRPWLALVPRIGYALEHLLRAEELYGIDRSAEVRAALEETAARPPAGTWGDTHRLAPWRALPPEALGEKPRLSGDHDCVLCTSSVPGLTDLAARGPAARYVWDLARRDDSRWVVPLGACGVPGSAHHRDQQPRWLAGDLVPVVTDWTRLRKEPDRPHRPEAPAGPSQPTVPAGPSQPTDPAGPTAAGPTDPAGPTDPAGPSQTTDPAGPSAATDAQHPPRSPMSDPYASRTAVHEQQVDGFGRVRVLPLDVTADVPVLHRWVSEERAVFWGMNGLTEQQVAEIYAHMDTLDTHHAHLVLKDGVPVALLQTYEPAADRVGECYPVQPGDIGVHLLLAPVEGDAARPGWTAGLLTPLTSFLLLGLDRRRIVVDPDVANAKAIARFLKQGFTAGPEVVLPEVDLPEVHIPEKKAQLAFLTREVAFGG
>NZ_CP022310.1|WP_142234123.1|3455999_3456722_+|SIP-domain-containing-protein
MVQGRGWEGAVLRLLRAKDFSLTVTDAEDVTADYRRVRFTDGGMLAATGVHPTMWVRLWFDNAGRPHQRAYTLVDPDPAAGTFGLEFALHEGCASDWARAAKPGDTIEATVQGTGFEEPSPTPSHLFAVGDPASLPALNSLLDALGSAPATIWFEGTLDGLPCRAEPGRHEVREVPRRDSGAALVERVRTDLPELLRATGNPYVWIACDTATTRTLSAFVRKELGVPRQRTHALGYWRAG
>NZ_CP022310.1|WP_142232230.1|3456746_3457349_+|Fe-S-cluster-assembly-protein-HesB
MDVTLHLAQDPDADALLGRSPLAALTGMLLDQQIPMEWAFKGPATIARRLGADDLDAHEIAAYDPDAFAALLSDKPAVHRYPGSMAGRIQQLCRYLVEHYDGDAEAVWRGVDDGKQLLKRLEELPGFGKQKAQIFLALLGKQLGVRPTGWREAAGAYGAERSYRSVADITGPESLAKVRAHKQEMKAAAKAAKAAKKTTG
>NZ_CP022310.1|WP_004943146.1|3457924_3458221_+|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKQQLDLETLLAEDSTFYGDLFAHVVKWQGDLYLEDGLHRAVRAALQQRQVLHARVLELD
>NZ_CP022310.1|WP_142194454.1|3458391_3459000_+|LytR-family-transcriptional-regulator
MGGQYRITGDKYPRMRRPRRRGRLVVLTVASAAALGAAGWGTVQLVDVFTGGGDSVSATGTKAACAAGPSPTASAKPLPEPGAITVNVLNATTRSGLAQKTADELKKRGFRIGEVANATKEYDKKVKGTGVLLGPAAALDTSLRVLATQLADAERRTDAARKGSEVDLVIGDAFKQLATKADADRALTALARPEPTSAPKNC
>NZ_CP022310.1|WP_142194414.1|3459094_3459730_-|uracil-phosphoribosyltransferase
MRLHVVDHPLVAHKLTTLRDQRTDSATFRRLADELVTLLAYEATRDVRTEQVDIRTPVEATTGVKLSHPRPLVVPILRAGLGMLDGMVRLLPTAEVGFLGMIRNEETLQASTYATRMPEDLSGRQVYVLDPMLATGGTLVAAIRELIERGADDVTAVVLLAAPEGVEVMERELAGTPVTVVTASVDERLNEQGYIVPGLGDAGDRMYGAAE

Crispr_ID: NZ_CP022310_9

• CRISPR_ID: NZ_CP022310_9
• CRISPR_location: 3704637-3704743
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_9

Consensus_repeat	Method
CGCAGCACGTGTCCGGGCACCCGC	CRISPRCasFinder

spacers of NZ_CP022310_9

>9.1|3704661|59|NZ_CP022310|CRISPRCasFinder
GCAGCACGTGTCCGGGCACCCGCTCACTCACGCGTAACCCGCACCCGTCCGCGCACGCC

CRISPR arrays and Neighbor proteins around NZ_CP022310_9

CRISPR arrays

The CRISPR arrays of NZ_CP022310_9

>merge|NZ_CP022310|9|3704637-3704743|CRISPRCasFinder
CCCCGCACCCGTCCCCGCACCCGCGCAGCACGTGTCCGGGCACCCGCTCACTCACGCGTAACCCGCACCCGTCCGCGCACGCCCGCAGTACGTGTCCGGGCACCCGC

>NZ_CP022310|9|7|3704637-3704743|CRISPRCasFinder
CCCCGCACCCGTCCCCGCACCCGC	GCAGCACGTGTCCGGGCACCCGCTCACTCACGCGTAACCCGCACCCGTCCGCGCACGCC
CGCAGTACGTGTCCGGGCACCCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142234136.1|3699059_3699989_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232321.1|3703241_3704054_+|hypothetical-protein	unknown	unknown	gnl|CDD|377524
NZ_CP022310.1|WP_142194222.1|3710800_3712504_+|DUF3459-domain-containing-protein	unknown	unknown	gnl|CDD|200471
NZ_CP022310.1|WP_142232320.1|3700702_3701914_+|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl|CDD|369272
NZ_CP022310.1|WP_142194236.1|3696841_3697519_+|snapalysin	unknown	unknown	gnl|CDD|280248
NZ_CP022310.1|WP_142232322.1|3707893_3709114_+|threonine--tRNA-ligase	unknown	unknown	gnl|CDD|237050
NZ_CP022310.1|WP_142232325.1|3713239_3714010_+|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232324.1|3712594_3712987_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232318.1|3697924_3698926_-|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl|CDD|377028
NZ_CP022310.1|WP_142232316.1|3691226_3693320_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|378410
NZ_CP022310.1|WP_167530052.1|3704819_3704984_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142194225.1|3706790_3707588_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142194226.1|3706471_3706747_+|hypothetical-protein	unknown	unknown	gnl|CDD|180688
NZ_CP022310.1|WP_142194237.1|3695689_3696631_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176106
NZ_CP022310.1|WP_142194229.1|3701975_3703055_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232319.1|3700133_3700574_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232323.1|3709153_3710137_+|nucleoside-hydrolase	unknown	unknown	gnl|CDD|239117
NZ_CP022310.1|WP_142194219.1|3714019_3714394_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142194227.1|3705082_3706426_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP022310.1|WP_142232317.1|3693598_3695668_+|DUF839-domain-containing-protein	unknown	unknown	gnl|CDD|253386

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142232321.1|3703241_3704054_+|hypothetical-protein	gnl|CDD|377524	pfam05552, TM_helix, Conserved TM helix. This alignment represents a conserved transmembrane helix as well as some flanking sequence. It is often found in association with pfam00924.	6.07763e-10
NZ_CP022310.1|WP_142194222.1|3710800_3712504_+|DUF3459-domain-containing-protein	gnl|CDD|200471	cd11332, AmyAc_OligoGlu_TS, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomaltooligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. Trehalose synthase (EC 5.4.99.16) catalyzes the isomerization of maltose to produce trehalulose. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP022310.1|WP_142232320.1|3700702_3701914_+|SpoIIE-family-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	3.14878e-34
NZ_CP022310.1|WP_142194236.1|3696841_3697519_+|snapalysin	gnl|CDD|280248	pfam02031, Peptidase_M7, Streptomyces extracellular neutral proteinase (M7) family.	1.75812e-74
NZ_CP022310.1|WP_142232322.1|3707893_3709114_+|threonine--tRNA-ligase	gnl|CDD|237050	PRK12305, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_CP022310.1|WP_142232318.1|3697924_3698926_-|endonuclease/exonuclease/phosphatase-family-protein	gnl|CDD|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	5.75702e-24
NZ_CP022310.1|WP_142232316.1|3691226_3693320_-|VWA-domain-containing-protein	gnl|CDD|378410	pfam10138, vWA-TerF-like, vWA found in TerF C-terminus. vWA domain fused to TerD domain typified by the TerF protein. Some times found as solos.	1.55469e-50
NZ_CP022310.1|WP_142232317.1|3693598_3695668_+|DUF839-domain-containing-protein	gnl|CDD|253386	pfam05787, DUF839, Bacterial protein of unknown function (DUF839). This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.	0
NZ_CP022310.1|WP_142194226.1|3706471_3706747_+|hypothetical-protein	gnl|CDD|180688	PRK06771, PRK06771, hypothetical protein; Provisional.	3.8158e-11
NZ_CP022310.1|WP_142194237.1|3695689_3696631_-|LysR-family-transcriptional-regulator	gnl|CDD|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	7.33434e-27
NZ_CP022310.1|WP_142232323.1|3709153_3710137_+|nucleoside-hydrolase	gnl|CDD|239117	cd02651, nuc_hydro_IU_UC_XIUA, nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains proteins similar to nucleoside hydrolases which hydrolyze both pyrimidine and purine ribonucleosides: the inosine-uridine preferring nucleoside hydrolase from Crithidia fasciculata, the inosine-uridine-xanthosine preferring nucleoside hydrolase RihC from Escherichia coli and the xanthosine-inosine-uridine-adenosine-preferring nucleoside hydrolase RihC from Salmonella enterica serovar Typhimurium. This group also contains proteins similar to the pyrimidine-specific uridine-cytidine preferring nucleoside hydrolases URH1 from Saccharomyces cerevisiae, E. coli RihA and E. coli RihB. E. coli RihA is equally efficient with uridine and cytidine, E. coli RihB prefers cytidine over uridine. S. cerevisiae URH1 prefers uridine over cytidine. .	9.50319e-119
NZ_CP022310.1|WP_142194227.1|3705082_3706426_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.5079e-09

Protein sequences

>NZ_CP022310.1|WP_142232321.1|3703241_3704054_+|hypothetical-protein
MATTLAIDFTGGLDDAWSKIATFVPKLVAFLVILAIGWFVSKLIARVLDRVLRKVGSERLSERAGTERMLANSKYDLTGIVSKIVYYALLLVTLQLALGVFGPNPVSAMINGIVAWLPRAIVAVVLVVVAMAIANAVRGIVSSALSSRPYGGTVARVLWAAIVALGVVAALGQAGIATDITRPMLYAALATVAGILVVGVGGGMIQPMQQRWERALSGMEQEQQRAKAGASAYQSGREDAMRNQPARERTDMPGGTDMRGGTDMGGGTGL
>NZ_CP022310.1|WP_142194229.1|3701975_3703055_+|hypothetical-protein
MPGTVLLLAASPLGRGRLVDAASVLPVLAAVPPAVLSGSDTANVVELADPLEPQAVLTRLRAAAAAPGPLTVYVTGQLHLDRRQRLPHLALARTTASTMRYTALPWHWFRDELRLRPAGATTLILDLHADAETWQTLCAPRPAGPPPLDCGRDNAVYGRVAPPPSRRGVAAPAYMKAVATILRSGWRPPEEDLHQQALARIAPESAGTDLVLVQRGPVPGDPHAAVTAAVRSGRHADADALAARLEQAASLAHGPASEEALHWTEVRADLAMLAGDAARSCGAWMAVATARLAAGQAPDAPAVEAAVDRAHHQWGRVGDPVRARELGAALAELRGRVPGRREGALDHVHRQLRQLQTQG
>NZ_CP022310.1|WP_142232320.1|3700702_3701914_+|SpoIIE-family-protein-phosphatase
MSPGSAGHGLHDRYPSAGRYGVVHRYEMLRVGGRSVAWVPPLLLLTAITVADYNTTGEFRIISWIVLVPGIAAALCGVWATAVFAVLAVAAYVTVDNAWPHQFQTGLPDFILVTVGGVLATLACAVRVRDERRALHMRDVTDTVRRTVLRPLPPGWGGLEHAGVYLTADTQARVGGDFYDIQPGPHGTRVLVGDVQGKGLGAVETAAVLLGTFREAGYHEPDLKVVAERLEIRMGRHRDYVRALGRDDGDRFATAVLLGFPADRTDVVDAVVFGHEPPLAVGPDGVRLLPAGTGLPLGYRDLAPGPPRVRRLPLAAGETLLLVTDGVTEARDGDGRFYRLRDDVTRAVAADPRVVAPAPLVAVVRDGTLRHSGGLLADDTTVFAVRRTRPERGEGREGGRSVS
>NZ_CP022310.1|WP_142232319.1|3700133_3700574_-|hypothetical-protein
MAHAAPRSGRTAERAGPADLFGPRAHRAAKLAVPVLVGLVFGYWAAANRRDAGPVTGWNLLFGFLTALVFALVFMALLALAPKLRREMHAVAWAAFSGTAVGFLFNQADGSVLRSTALGLAVAAGVFAVMFYRFYTHEDAAGHRTG
>NZ_CP022310.1|WP_142234136.1|3699059_3699989_-|hypothetical-protein
MRNALSATLVALACLLAPCGALAAWAAFGLADTGRYVSTMAPLAADPDVRDAVADTVGDEAVRELAPGAAHTTVAPFVRDAVRSFTRTEAFRTAWEAGNRAVHDAVLRALRDDAAAHGPVTVDLAPVAAQVRQRLTADHVPFADRIPVAHTRVAVLPADEVPALRKGYHVLDAAAFWLPLGTVVLAAAGIAVAACRRRALTATGLGTALGGALLAVAVAVGRHLTLADLSDRLHRPAAAAVYDALTATLRTASWLLLALGLAVALASWLTGRRPLRLHRTPSPTAPAPAAVAAAPGSGTPAPAPPGTRA
>NZ_CP022310.1|WP_142232318.1|3697924_3698926_-|endonuclease/exonuclease/phosphatase-family-protein
MDTATADPTAGDDRAGRSGRGRRSGAWCAALLFAGVSAVVGCRIADTDGITPVPQLLAFLPGLLVPTAAGLLCTVLARWWTGAVWGVALLGLLAWYIEPYGRTGEPAGPPVADLRVLTSNVEFGQGTGALVDAVRREEPDLVFVQECEYRCAATLRRELAGTHPHRQAVEGGGSAGSVILSRFPLTARDAVPGTMGMPGAVADVDGHPVRLQLAHPMPPLPDQVGLWQRELGRLREAAAADRDTPTVLAGDFNASQDHAAFRRILDTGLRDAARLDGADRTPTWPSRTAPAFGTQIDHVLVSEEFAAQRARFLDLPDTDHRALVVDLTLHAGG
>NZ_CP022310.1|WP_142194236.1|3696841_3697519_+|snapalysin
MRMRTPLSVLAATGLGLTALGLGTAPASAATAPDAAAPVAAYAGSAEEAAANRAFFEAVLKSAAEKRAANPTGTAAVTVVYDASRAPSFATQIARSTQIWNSSVSNVRLQSGTSGADFAYYEGNDSRGSYASTDGHGNGYIFLDYQQNQTYDSTRVTAHETGHVLGLPDNYSGPCSELMSGGGPGPSCTNAYPNATERSRVNQLWANGFAAALDKAEKALEKSGR
>NZ_CP022310.1|WP_142194237.1|3695689_3696631_-|LysR-family-transcriptional-regulator
MELEVRHLRALCAIADTGSLHRAARQLGVAQPSLSTQLRRIEQELGGTLFVRARTGCRPTPLGRLVLSRARPLVTELRSLVTEARAAAAGGRQLRIGSTASRALAGWLRRLRRHCQEPTLHMDVSANALLRMVADGQLDVAFVHEVEGCPLRVPEGLSIRVLVEREPQFVSLPADHPAAAHPVVHLSDLAGDRWMIDPAVDGEWDAVRRVLRAAGINPRVLHGDYHTAASLVAIGEVVTVCQPTSLPRPETAVRRLYGDPLGVRLLLAARTDTELEGVYPDLVEAYREVVGQAPAYREWLESGGPGLPVPALP
>NZ_CP022310.1|WP_142232317.1|3693598_3695668_+|DUF839-domain-containing-protein
MRKLLPLIGTPSGSHPGGRSAMTCRFRCGDACFHEVPNTSSNEYVGDVIAGALSRRSMMRAAAVVTVAAAGAGAAGVAAAPEAQAAPAAKGGSRKPQGARGLRFAPVAPNTADAVTVPEGYRQDVVIRWGEPILRGAPAFDPEKQSAGAQAGQFGYNCDFLSLLPLRGERGRQLLVANHEYTDEVLMFRDYDPENPTREQVEIAWAAHGFSVVAVDEDRRSGRLTPVARHQLNRRLTATSEFRLTGPVAGSDLVKTSADPSGTKVLGTLNNCSGGTTPWGTTLHGEENFNQYFANSSRATDKRYGIGTGATERKWERFDKRFDVAQEPNEVHRFGYVVELDPYDPDSVPRKHTALGRFKHEAATVRLTHDGRPVVYSGDDERFDYFYKFVSSKRMRHGNSRSAREHNLSLLDEGTLYVAKLTGDSPAIEIDGTGKLPKDGEFDGSGQWIPLATATADGAVSHVEGMTAEEVFVFTRLAGDKVGATKMDRPEDIEPNPVTGKVYVALTNNSNRGKAGYAAADEANPRNLNKHGHVLELTERWNRPESTTFAWSLFLVAGDPEDPATYFAGFPKESVSPISCPDNVAFDAHGNLWISTDGAALGSHDGLFGVATRGDRRGELKQFLTVPNGAETCGPIIQDRRVLVAVQHPGEVDGATVDQPASTWPDGPGTYVRPAVVAVWREDGRDIGV
>NZ_CP022310.1|WP_142232316.1|3691226_3693320_-|VWA-domain-containing-protein
MGILTLLRNAFGRSRKARGAEAEGAAEAAGTTRTSSASSGPDTTPSPEPAAKPATDSAPATATETSAAASTETSAATSAAPKVPAPSSEPTPPSRTASVPEPREEHDLVSAAFDNVTVPRPTTPSDKPTEPTAEAPEPTAVEPTVEATEPTAVEPTVEATEPTAVEPAKPETAPVEAEAEATEPETAPEAEAEAKPEAEAEAEAKAEPEAEVKPEPETAPEAEAKPEAEAEAEAEPETKPEPEAATKPEPEPEAATKPEPEPQATADVEPEATPEAEPTPEPEPSPAPEAETKAEPEATPDTEASVEEPEATPDTEASVEEPAAEPEAEAKPEADTTPKAEPQPAAAPEPEPEPEPEPATAPEPEPEPESKPEPEAAAEEPAATAQEPEATPEAPELTAQEPEAATTAAPEPEPATKATEAREAAEAPEAPEAPEAADGEAAPQATPAPDDATGTGGAGGSDAPAEGEAEADNATEPERDPAPAPTADVPPTLTTAHHAATAALAKNGLTGTRAKVYLVLDRSASMRPYYKDGSAQALGEQTLALAAALDTDATVHVVFFSTELDGTGELTLTDHENRIDELHAGLGRMGRTSYHAAVEAVLARHADEPAGTPALVVFQTDGAPDAKTPATQALNDAAKNHPAVFFSFVAFGEHDNKAFDYLRKLKTGNASFFHAGPTPRELTDQELYEGILATWRP
>NZ_CP022310.1|WP_167530052.1|3704819_3704984_-|hypothetical-protein
MLERTRTTGRYARGFAAAVAAVTALVLAANAGPARATHSQPDRQTTAPAEATAR
>NZ_CP022310.1|WP_142194227.1|3705082_3706426_+|helix-turn-helix-domain-containing-protein
MGERDEPRTIGRRVQQLRVQRGLTQRQLAEPVYTPAYISTLEAGRVRPSDEALRHLADRLGVAFEELATGRPARLVTELHLRLTEAQRTLAVGEAEAAVEQYAGLLAEAEEHQLVEEQAAALLGLGECALETGELAGGRQYFERAEARLADAPLPARVPALRGRAVSHYLAGELRYAVYLLESTIDELNRGGLHDPDALLLLYASAIGPYMDMGAHARAAQAAEFALALAPQSGDPALVARMHRSVARTLLAEGRLAEADASLAKAAELYRGLQLRTELANCHWMRGYVYAQNGELERAEGELREALSMLSAKRASLYSSQVTVELADVLHRRGSSAEAAALLEDVLGGLSPERGAVHAAAAHRLLGIIAEDARDAERAEEHYVRAMSLLERAGAAGDLADLCRLLGDLLRRTGRVEAALDAYRTGLGHRTAPGTTTLGPAPAQPPV
>NZ_CP022310.1|WP_142194226.1|3706471_3706747_+|hypothetical-protein
MDIAVLLLVCVVMLGVTTLQTRLARAERRAARAERKLDLVLAHLGLREETPGHDEVVALVREGRKVQAVKRYREITGADLLEAKEAVDRLS
>NZ_CP022310.1|WP_142194225.1|3706790_3707588_-|hypothetical-protein
MTTARVLLASALSVSALLAAAACSVGRDDPRALPLPEGVPQPSSASATAAASATERPAPAPPSLSEAQLRAALVTETDLGEPWMASRGAATWRDGLLKADTDHPDCRRLLDSLYTEELFGAPSGPRATATLDDTYNDTQLRHQVAAYRPADVDRVLSWLATLPDTCERFRATTTRAGAQVVEVTELPLPEAGDARTGLRVTMTGEASDGMPTYLTVDLAGVRVGDDAITLTNGGFGAVLPEVTQAVAQLGAERLAEVARQGRVRV
>NZ_CP022310.1|WP_142232322.1|3707893_3709114_+|threonine--tRNA-ligase
MHDHRRLGRELGLFDTDPLIGAGLPYWLPDGALVRHTLEEYVREAERAAGYRHVYSPVLGKRELYEISGHWAHYSDDMFPPMELGSEQVVLRPSLCPHHALLYRSRSRSYRELPYRMAELGGMYRSELSGVLGGLTRVRAIHLNDAHIFCTPDQAVEEARAALALIARAYADLGIRAARHRLSLPGGGGKYVADPALWERATALLREVLDASGLAYEAVEGEAAFYGPKIDVQIADSAGRETTLSTVQIDFHQPERFDLHYTGPDGARHRPVMVHRSIIGSVERAVAHLLEEHGGAFPVWLAPVQLVVLPVGEDQEERAYDVVRRAGGLGLRAEVAGCGEGSLGARIRRARLVPYQAVLGAREAADGLLAVRLSDGRRPGALPVQEVLRRVAERAARRGTALWDPA
>NZ_CP022310.1|WP_142232323.1|3709153_3710137_+|nucleoside-hydrolase
MTHGQTVPVIIDCDTGVDDALALLFAVRHPGLDLRAVTCVAGNTDVAGVVRNTLTVLEQAGAPDIPVARGAERPLIEAPRSARHVHGHDGMGDLNLPAPRRTPADVDAVTLLRREILASPRPVTLVPTAPLTNIALLLRTHPEVTRNIERIVFMGGAAGAGNATAVAEFNVWHDPEAAAILLTAGVPITMYGLDVFTRVVVPGADVRRLRASTEPGTRLAGELLAHRPATPGSRPDDPAEDAGGLGDAGALCAVADPEGLTTHRLPVEVSLAPGPTRGQTVVDRRPRVGESEIHGDAREQPLVDVGLDVDVERYVRLYLGTVERTEA
>NZ_CP022310.1|WP_142194222.1|3710800_3712504_+|DUF3459-domain-containing-protein
MTERATTPDPRPPHPAPDATPDLSSKNPDWWRQAVVYQVYPRSFADADGDGLGDLRGITRRLTHLAALGVDALWLSPFYPSELADGGYDVADPRDVDPRLGTLDDFDGLVREAHRLGLKVIVDIVPNHTSHQHVWFQEALRAGPGSPARDRYVFRDGRGPSGELPPTDWQSVFGGSAWQRVPDGQWYLHLFAAEQPDLNWSHQDVRDDFRTTLRFWSDRGVDGFRVDVAHALAKDLSEPLRDLGAPELSGEAALTEFAPGTHPFYDRDEVHEIYRDWRKILDAYSPPRMAVAEAWVPGARRALYARPDELGQAFNFEYLQTPWDADALRRVIGDSLATAHAAGASATWVLSNHDVVRHASRLMLPPDTDENAWLLSGGRAPAVDTAAGLRRARAATLLMLALPGSAYVYQGEELGLPEVADLPTEVLQDPIWEQTGRVRKGRDGCRVPLPWTTTGPSYGFGAAGAWLPQPPAFAAYAVEAQDGVEGSTLELYRTALRLRRKLLAGETLTWAREAPAGVLQFDRGDGWRCVTNLSAEPVSLPAGEVLLTSAPLEDGRLGPDTTAWLGR
>NZ_CP022310.1|WP_142232324.1|3712594_3712987_-|hypothetical-protein
MITELAVERVEFTCGSCWHRWSVDYDVQRNLDGRGEEWEYFYRDNTAVPSPYTPEGAPPCEHCGRHWVGHLVARRPVPLPGTSDAPRSRIPPEGLHRPERLLAPLLGADGHPQPPRDGPADRPTANPDSR
>NZ_CP022310.1|WP_142232325.1|3713239_3714010_+|carboxypeptidase-regulatory-like-domain-containing-protein
MNRSSRTAAAALSAAAILAGAWPSTAAPATSDDGHGAAARARVSWGTVTVPPGRAGLLKATGLTGPDLGTGSTLTLTAPAGARVTGTPLDAPGYRGAVGADGRTAVYTATSAERPWRAGTFPFVLTVPADAVPGTRLSGCSLRLADAAGTTRATGGCQVTVGLAEPQLTSPEPGVPLTARPVVAGTAHPGARITVRGPDDGTVCTAVAGPDGRWTCTPGEALPEGPGRLQATATLNGASATSEQIQITVGAPAPGR
>NZ_CP022310.1|WP_142194219.1|3714019_3714394_-|hypothetical-protein
MSMAAYEVLAASQHVWNVFAAFVGGLVVAGALIWAVRIGMRYMDQEEPRPRADEQPRLPDGGAVHELREMREPDEIPDMSKTGSRRLMPYELHHAASRTGKDQNRKRWLPGSSGAFGSGGPGHV

Crispr_ID: NZ_CP022310_10

• CRISPR_ID: NZ_CP022310_10
• CRISPR_location: 3732751-3732827
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_10

Consensus_repeat	Method
GCGCCGTACACCTGCGTCGCGCTCC	CRISPRCasFinder

spacers of NZ_CP022310_10

>10.1|3732776|27|NZ_CP022310|CRISPRCasFinder
TGCGTCGCGCTCCTGCGCCGTACACCT

CRISPR arrays and Neighbor proteins around NZ_CP022310_10

CRISPR arrays

The CRISPR arrays of NZ_CP022310_10

>merge|NZ_CP022310|10|3732751-3732827|CRISPRCasFinder
CGGCCGTCCACCGGCGCCGTACACCTGCGTCGCGCTCCTGCGCCGTACACCTGCGTCGCGCTCCTGCGCCGTACACC

>NZ_CP022310|10|8|3732751-3732827|CRISPRCasFinder
CGGCCGTCCACCGGCGCCGTACACC	TGCGTCGCGCTCCTGCGCCGTACACCT
GCGTCGCGCTCCTGCGCCGTACACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142232338.1|3732915_3733758_+|DUF2182-domain-containing-protein	unknown	unknown	gnl|CDD|378321
NZ_CP022310.1|WP_142232345.1|3750896_3752213_+|diaminopimelate-decarboxylase	unknown	unknown	gnl|CDD|143505
NZ_CP022310.1|WP_142232340.1|3734823_3736857_+|TerD-family-protein	unknown	unknown	gnl|CDD|376767
NZ_CP022310.1|WP_142232335.1|3729514_3730009_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142234137.1|3741696_3743802_-|zinc-carboxypeptidase	unknown	unknown	gnl|CDD|349432
NZ_CP022310.1|WP_142232330.1|3722095_3723229_+|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380650
NZ_CP022310.1|WP_142194199.1|3744127_3745444_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232333.1|3727823_3728825_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl|CDD|223682
NZ_CP022310.1|WP_142232342.1|3738223_3741700_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173787
NZ_CP022310.1|WP_142232343.1|3745635_3748692_-|hypothetical-protein	unknown	unknown	gnl|CDD|379396
NZ_CP022310.1|WP_142232337.1|3731202_3732414_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224172
NZ_CP022310.1|WP_142194211.1|3723293_3724460_-|DUF1565-domain-containing-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232334.1|3728925_3729516_-|esterase-like-activity-of-phytase-family-protein	unknown	unknown	gnl|CDD|379191
NZ_CP022310.1|WP_142194209.1|3725908_3726718_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224045
NZ_CP022310.1|WP_142232344.1|3749010_3750681_+|PucR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379258
NZ_CP022310.1|WP_142232332.1|3726717_3727827_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl|CDD|227119
NZ_CP022310.1|WP_167530054.1|3736934_3737651_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232336.1|3730165_3731110_+|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl|CDD|132002
NZ_CP022310.1|WP_142232339.1|3733828_3734485_-|DUF1326-domain-containing-protein	unknown	unknown	gnl|CDD|369182
NZ_CP022310.1|WP_142232331.1|3724762_3725806_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238566

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142232338.1|3732915_3733758_+|DUF2182-domain-containing-protein	gnl|CDD|378321	pfam09948, DUF2182, Predicted metal-binding integral membrane protein (DUF2182). This domain, found in various hypothetical bacterial membrane proteins having predicted metal-binding properties, has no known function.	1.51045e-55
NZ_CP022310.1|WP_142232345.1|3750896_3752213_+|diaminopimelate-decarboxylase	gnl|CDD|143505	cd06836, PLPDE_III_ODC_DapDC_like_1, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Uncharacterized Proteins with similarity to Ornithine and Diaminopimelate Decarboxylases. This subfamily contains uncharacterized proteins with similarity to ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. DapDC participates in the last step of lysine biosynthesis, the conversion of meso-2,6-diaminoheptanedioate to L-lysine. Proteins in this subfamily may function as PLP-dependent decarboxylases. Homodimer formation and the presence of the PLP cofactor may be required for catalytic activity.	0
NZ_CP022310.1|WP_142234137.1|3741696_3743802_-|zinc-carboxypeptidase	gnl|CDD|349432	cd03859, M14_CPT, Peptidase M14 Carboxypeptidase T subfamily. Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. CPT has moderate similarity to CPA and CPB, and exhibits dual-substrate specificity by cleaving C-terminal hydrophobic amino acid residues like CPA and C-terminal positively charged residues like CPB. CPA and CPB are M14 family peptidases but do not belong to this CPT group. The substrate specificity difference between CPT and CPA and CPB is ascribed to a few amino acid substitutions at the substrate-binding pocket while the spatial organization of the binding site remains the same as in all Zn-CPs. CPT has increased thermal stability in presence of Ca2+ ions, and two disulfide bridges which give an additional stabilization factor.	3.81603e-83
NZ_CP022310.1|WP_142232330.1|3722095_3723229_+|substrate-binding-domain-containing-protein	gnl|CDD|380650	cd19995, PBP1_ABC_xylose_binding-like, periplasmic xylose-like sugar-binding component of the ABC-type transport systems. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	5.72019e-84
NZ_CP022310.1|WP_142232333.1|3727823_3728825_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl|CDD|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	1.52324e-78
NZ_CP022310.1|WP_142232342.1|3738223_3741700_-|S8-family-serine-peptidase	gnl|CDD|173787	cd00306, Peptidases_S8_S53, Peptidase domain in the S8 and S53 families. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	2.38904e-08
NZ_CP022310.1|WP_142232343.1|3745635_3748692_-|hypothetical-protein	gnl|CDD|379396	pfam13861, FLgD_tudor, FlgD Tudor-like domain. This domain has a tudor domain-like beta barrel fold. It is found in the FlgD protein the flagellar hook capping protein. The structure for this domain shows that it contains a nested Ig-like domain within it. However in some firmicute proteins this inserted domain is absent such as Q67K21.	1.01113e-06
NZ_CP022310.1|WP_142232337.1|3731202_3732414_+|FAD-dependent-oxidoreductase	gnl|CDD|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	3.60028e-57
NZ_CP022310.1|WP_142232332.1|3726717_3727827_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl|CDD|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	2.23412e-75
NZ_CP022310.1|WP_142232334.1|3728925_3729516_-|esterase-like-activity-of-phytase-family-protein	gnl|CDD|379191	pfam13449, Phytase-like, Esterase-like activity of phytase. This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.	4.35769e-08
NZ_CP022310.1|WP_142194209.1|3725908_3726718_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.41645e-132
NZ_CP022310.1|WP_142232344.1|3749010_3750681_+|PucR-family-transcriptional-regulator	gnl|CDD|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	2.0843e-16
NZ_CP022310.1|WP_142232340.1|3734823_3736857_+|TerD-family-protein	gnl|CDD|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	7.58266e-66
NZ_CP022310.1|WP_142232336.1|3730165_3731110_+|RNA-polymerase-sigma-70-factor	gnl|CDD|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	3.25701e-107
NZ_CP022310.1|WP_142232339.1|3733828_3734485_-|DUF1326-domain-containing-protein	gnl|CDD|369182	pfam07040, DUF1326, Protein of unknown function (DUF1326). This family consists of several hypothetical bacterial proteins which seem to be found exclusively in Rhizobium and Ralstonia species. Members of this family are typically around 210 residues in length and contain 5 highly conserved cysteine residues at their N-terminus. The function of this family is unknown.	1.16358e-72
NZ_CP022310.1|WP_142232331.1|3724762_3725806_-|ABC-transporter-substrate-binding-protein	gnl|CDD|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	4.03601e-79

Protein sequences

>NZ_CP022310.1|WP_142232337.1|3731202_3732414_+|FAD-dependent-oxidoreductase
MQHRIIVLGAGYTGAVAAGRLAKRLHRDDVAVTLVNAEPDFVERVRMHQLATGQELTSRPLAAMFAGTGVELRQAKVTGVDVDRRTVAVTGPDGEAEELAYDTLVYALGSGWNDQGVPGTTEHAHEIAGRPGALRLRERLAGLGAGESVVVVGGGLTGLEAATEIAESRPDLDVALAARDGLGDWLSPKGRRHLRKVFGRLGITAHEHTTVTRVDADRVTTADGASLPAAVTVWTTGFAVHPIARATALEVTDTGQVVVDHTMRSVSHPDVYAIGDAALAMGAGGKPLRMSCASGGFTALHAADAITARLTGGKPPKGTIRYFNQCISLGRKEGLIQYVTADDRAVRAALTGRFAALYKELICKGAAWSAANPTFGLPVRRRRALHEQAAGRPGPAETAEASA
>NZ_CP022310.1|WP_142232336.1|3730165_3731110_+|RNA-polymerase-sigma-70-factor
MALTAHDVDRFMASRPRLEAIAYRLLGSASEAEDAVQETFLRWQDADTEHIRVPEAWLTKVLTNLCLNQLTSARARRETYVGAWLPEPLIAGDPMLGPADSAEQRESVSYAVLVLLERLSPNERAVYVLREAFGYTHREIAEILDVSETASQQILHRAKKHVADGKARSDIDEAAARRIVDEFLAAATSGRTEPLVRLLTADAVAIGDGGGKVPARAKAFEGAVAVAKFLRGLFKPGQAKRALLGGQAGLYATTANGEPAVVVVVDGRVVGVMCLEVTAEGITAIRSQVNPDKLERVTRHWTATDHGEPLFTAF
>NZ_CP022310.1|WP_142232335.1|3729514_3730009_+|hypothetical-protein
MASQIITLVGVLLGAVTSFFATTLAERAKFRQAMATRWDERTLDSYVEYVSCVKETARFAGRVLDVRERGEDPSEALLEMEAAEARRSVLFEGFVLLAENTASQAASTVNERLWDLLRCARRPQDTPDTDRELLGPALIDALNDLHKAARTDLAIGTSRTGRRR
>NZ_CP022310.1|WP_142232334.1|3728925_3729516_-|esterase-like-activity-of-phytase-family-protein
MWIKVAARTAPRADTAGSAAPAEGSPRSAGGRPPPVRFRRRTEAYAEPRTGQAALLLLFTAAPAGPGRRVGRSGSAVGHSAPQRSTPEERCCGRLAVVERDKLNGPAARIKRIHAVDLPRGAAPEGALTVLPKRLVHDVLPDLRATKGWTQEKLEGFAVAGNGRVFAVTDNDGLDDSTGETVFLDLGSRRGMFGRD
>NZ_CP022310.1|WP_142232333.1|3727823_3728825_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MSGAASRRVGWMAVGLLLLLLAVMLSLAVGSRATAPSVVWDALVHGGTSPDAQVVRSLRVPRTVIGVLVGVALAIAGTVLQGITRNPIAEPGILGISQGASLGVVCAIAFLGVHSLTGYVWYAFAGAGAAAICIYAVASGGRDGASPVKLALAGAAMNAFLASLVAAILTTDARALDEFRFWDVGSLSGRDATIAGQVWPFLLAGLLLVLATARGLDALALGDDIARGLGRNVALLRATGALGATVLTGAAVAAAGPIAFTGLAVPHIARALVGPAHRWLLPMAAVLGPVLLLLADVLGRVIVRPSEVPVAVMTALAGVPFLVVLVRRRTVAA
>NZ_CP022310.1|WP_142232332.1|3726717_3727827_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTDLRTGRTGSVPKAAGPGRLRPAGHTVLRPGRGGSFLLHRRSMVLAVVLAVSLAAAVVASLCVGESFVAPGEVVRVLLGLPSQSELVVGTLRLPRLVTGLLVGVAFGISGALIQTVARNPLASPDVIGVTHGAGAATVAAMTFGLTSYAVLPYVSVAGGLLAALLVYLLAWRGGLAASRFVLIGIGISVALGALTRLLVTKGDYLVAQQAKTWLTGSLNGRGYDQAAPLATVLLLLLPLLLWAARAQRGSAFDDDTATALGIRLDRVRLGLSLLGVVLASVATGAAGPVDFVALLAPQIARRLARTPHIPLVCSALTGALIVVVADLLARRLLSPLELPVGVFTALVGAPYLMWLIVRTRTSRSGGTA
>NZ_CP022310.1|WP_142194209.1|3725908_3726718_-|ATP-binding-cassette-domain-containing-protein
MGNRLTAQELTLAYEDRTVVDGLDVEIPDGKVTVIVGPNACGKSTLLRALGRLLKPRSGAVLLDGTDLSRLPSRRIAQVIGLLPQTPVAPEGITVADLVSRGRQPHQKWWQQWSETDETSVAQALERTSTADLAERPVDALSGGQRQRVWIAMALAQDTDLLLLDEPTTYLDIAHQVEVLDLVRQLNRERGRTVVAVLHDLNQAARYADHLIAMKAGRIVAQGPPAGIVTAELVQEVFGMASVVVPDPVTGDPLVVPGPPRQAGPRTGE
>NZ_CP022310.1|WP_142232331.1|3724762_3725806_-|ABC-transporter-substrate-binding-protein
MSVRRRGLSAAALALAAALSLSACGSSGGEGASAESSAGAGDKKAVAQGGDDFADAAAKTAAMGTDAEPGEWPRTITHAMGETELKAQPRRVVVLDVGELDNVVSLGIEPVGLAPTEGSPELPSYLKDDAGSPKNVGTINNLNLEAIAALEPDLILGSQLRAADKYDELSQIAPTVFSLRPGFTWKENYLLNAAALDRTAEAKQKLAAYEKKAKALGEQLGADKPTVSMVRYLPDGVIRLYANASFIGTILKDAGIPRPKNQDIDDLAAEISAENIDQADADYIFTGVYGDPKATDKSKAQGNPLWKNLGAVKAGHAFDVPDETWYLGLGVTAAEEVLADLEQRLTQ
>NZ_CP022310.1|WP_142194211.1|3723293_3724460_-|DUF1565-domain-containing-protein
MHLSHALAAAGLLAGSLVALSGTPAQAASELYVAPGGSDSASGTQSDPTTLTSAIERIAPGGTIHLRGGRYDHAQTVTIPAGNNGTAADRTQLVAHAGETPVLNFSAQSESSSNRGLAVNGSYWHIKGLVVERAGDNGIFVGGSHNVIERTVTRHNRDTGLQLSRTTSDTPRDQWPSHNLILSAESHDNADSDGEDADGFAAKLTSGPGNVFRYAVAHHNIDDGWDLYTKSETGPIGAVTIEDSLAHGNGTLSDGTQNSSGDRNGYKLGGEDIGVDHVVRRSIAYDNGKHGFTYNRNPGSMTVSGNVSVDNAERNFSFDAGTSVFRDNTSCRGDDGSNDKTVGDADGSNQFWTGSNGSRCADYSGALDWSFAADGSLDVTFGGNRVTP
>NZ_CP022310.1|WP_142232330.1|3722095_3723229_+|substrate-binding-domain-containing-protein
MIPRTTPHCVRRVTLALTAGLSALSLTACGVVGGSGDGADSASSRKSYDITVGLLLPDRDTARFEKFDYPLIKERISSLTNKQGKVVYANAEGSEKRQSEQFRKMVADDVDAIVVDAVDAEAVEPDVRRAKDAGIAVIAYDRLAQGPIDAYVSHDNELVGQVQGRALVNALGDAAEKSKVVMMNGEPADPNTALFKKGALSELDGHVDIVKSYDTTKWLPEVAAENMRKAIKEVGLGDVAAVYSANDGMAGAVIEALQDAGATELPPVTGQDADLAAVQRIVAGTQYMTVYKSFLLEATGAADMAVAKVQDRSIQFDALARERVDSPTQRDIPAMLVPVVALTRENIEDTVIQDAVYTVEEICTEKYAAACAEIGLL
>NZ_CP022310.1|WP_142232338.1|3732915_3733758_+|DUF2182-domain-containing-protein
MRHSRASAPAFVPARSPAPTGRGGGLLPARELAAAWSVVVLIAVPAWVLTIGQARDMGIEPGTMGMGLPLFLLLWVTMTAAMMLPSMAPVALTWARGIGRQSSGRTRAARTAEFVCGYLLVWTAFGLLAHAALALTGGLVEDRPGAGRWIGSAAFLLAGLYQLGPLKNVCLRHCRDPMSHLVRYAGFRPPARDLRVGLHHGVYCVGCCAGLMVVLIPLGMMNVAAMAALAVVIFVEKLWSRGPLLVRVVGVVFLVLAVLAPFQDWLLPGLRDAMPPMDDM
>NZ_CP022310.1|WP_142232339.1|3733828_3734485_-|DUF1326-domain-containing-protein
MTEQATTGTRWHLTGDWFDVCKCAIPCPCTFAQPPTYGDCEGVLVWHIKEGSFGDVRLDGLNVLMLGSFTGNPWAGTHTDPYAAVFFDERADERQRGALGAIFGGEAGGWPAQFGEMFHPEMRGMDFAPVHVEIDEDLATWRAEVPGRVTATAEALTGPTTPDGARVQVHNAPGSEVGPGQVATWGRATADRADAFGFTWERSGKSSKYFPFDWSGPD
>NZ_CP022310.1|WP_142232340.1|3734823_3736857_+|TerD-family-protein
MYELVKGANVGLTALSENAGSVIVGLDWTSPTGDGDADVSVLLLDADGKVRSDADFYFYNNPVAADGSVQLLGKTPTGNGSQDRISFDLTAIPDRVDRIVVAASRYDGGHFCELGDLQMTVADGSGESLLRFSIDDAGSVSAFIFGELYRRGGEWKIRAVGQGYATGLAGLATDFGVDIDDDAATGDAPDAGPDDEQSHVTEPAAEPAPRPTLEAVPAPRRSDDETEPKKTRARPRTAKKKVTLPKAAAKSLAENESWKQSRLFPVSVLKSDRDRETRATSVLLSVMAQIPEFGRRLTAAFGAPAGRMETFTEVSLPHGDTPRRPDGVIRVERAGKLWTALVETKTNGNALKAEQVQVYTDIAARRGYEAVITLSNDVALEGSPLVDVRIDGRRKHKVALWHLSWAEVVHQAQLLIRHEGVGNMAHAWLLQELLHYLQHENSGCHGFQNMGSAWVPVRKGIDDETLCQGDPRALEVVESWERLIRQVCLGLGGELGQKVLPVQRSRRGTDPGARRSLMADRLCLEGRLQAELRIEGTPGILAINADLRTGKLRTSVDIPAPEQGYPLTWAKRLVRRLAEAPADLHIETLVEGEAGGPRGTLERLRPEPADLLPKNGTQITGFRLSLFKGMGSSRGNAETGFIRSVDDAVHRFYGTVVTHLDRPAPRRTTSGERTAGV
>NZ_CP022310.1|WP_167530054.1|3736934_3737651_-|hypothetical-protein
MPHQQLGDMQMVADPGLTVNQRELVLKIQTSSKMLAVGFVLGIPLTFGGLHYGITQQPSGFVGALAGLVLLAVGVAGYLKSAALRRQLRQITPDAWRSPAANLPGARKAATQAAYLNGLLVVLSLGATGWLLVKGAGWGAYGNSFGFGALLLGAAIPAALGLAAASTVPQLLRVIPAGAKVGRSLYSVIMAVGVLMLVNGVKNGEPTGLAVGGTVTLVCLTAMTLLGRAARRMRGETV
>NZ_CP022310.1|WP_142232342.1|3738223_3741700_-|S8-family-serine-peptidase
MTRRVRTRFRRTAAVVSLGLALSLLPLAGAGAAEGADVTVASVGGQPVGSDGAVRQPVSGTVDVTGTARTGTPGPSADPSPLHADAGDSPFLTTGGKAPLLGSAYGGTPPYAWSWSAAQGALTGADSASPAFDATGLAPGTYPVELSVTDAAGARTSDTVTAVVGEETSGELLAETRTDATPGVFPADQSVEFPFEVPAGVRSLDVSLSWTTQEQDYDLRVTDPSGTVVARSESSGHPEKTSVADPAPGTWQVVAVKWATVTADVTARVVARSGGPDPRPQVKAGGPYAFETGAEQRLAGTVTGGTDPVTAAWDLDGDGRFDDGTGTTVTPALPEGRHLVTLKATDARGLERRETTSVLVGDADRLDAAPPVTVIGVADTGINPYHLEFSARTYPDPDVLELTRNFTRHPSEYIPGYPATAPAIPVTLGKGYLPEEDKDLWTGERVKGGQLHWIPGTKIIGAYSSSVDGAHPVLDDHGHGTGSASVSAGNRYGYCPTCLLVMVEGLDETVATGYPWVDITSHSFGYVGGAPVGPVLSGEEVTKEAAERGQTVLFAAGNGVGNAFDVPVSTWHSDQTGPDWNITVGALRRDDQRAVVGDGIPVHLSSWGIGSLPSACHTGVLCQDQFSGTSAATPYTAGVFGTTLQRVRDAIGDARAGQKDGQVVAEGSAVDASVYLSDGRLTRGELREAVLKNAFPLGADDLPSASWPLAAPHTAGNVLFEGYGAATPETARRAVDVLLGRALLPERPVEDDFFAADRAVRDHLWGGYDRDGDGTEDTAPLPGGVSAGLDDVATPDGALGVLRGTLAAREESTGPGQATYADEAFAYYLHQGPDCSGERTMDRTDRAGDADGCAVGDTLSSAAPYLPTAAYPSADTLAAPLAAGSQARAELYVRTRAPAALVGPSVVLLATDREIGRGKATARPVTGAWTKVTVEFETDRPAFTGEQLTVQLLSDTTALLAVGHEGDHATRLTLDPAALPPSGLDFGATVEAPADGGEVREGETVVAGGRFAFPDAGTDPEGVGGRPETHRVQVSVDDEDFGSPLSAQLDEATGTWRVEAGRFGVGEHVLYARAVRDGTPSRVARTSFRVVPDARVEWQVVARNAPADPAAWRPATGLADWSFTLATSSYGTGHRTVVVRLVERGTETARDGVRVLFR
>NZ_CP022310.1|WP_142234137.1|3741696_3743802_-|zinc-carboxypeptidase
MGAPRRSRRSRLIACAVAVTAVVIGGAVAPGAPAPAAAADAFRPQLVTVSTPTRADKDRLVALGLDLTEHAGHDYVEVVLHRAADQLALTGAGFDWQVRIPDLVERESEVNAANRAYAAATATSPLPSGRTTYRGLGAYEADMDRLVEEHPGLVRKVTLPHRSLEGKAVHGVEIAHDVDAPEDGRPVFLMLGLHHAREWPSGEHAVEFAFDLARHHGTDERITALLKKARVIVVPVVNVDGFEKSFNDGQLIDLRSVDEGGTGSILATPGNAYKRKNCRTVDGTAPLADECALASSPGGFGAGVDLNRNYGGFWGGPGAAAEPVQATYRGAGPFSEPETQNIRELISGRQVTGLITNHTFSNLVLRPNGVAPDTTGPDGLPLGDPPDEAAMKELGDRMAEQNGYTSQHSWQLYDTTGSTEDWSYNATGGYGYTFEIGPDEFHPPFPEVVDEYLGAGAYAGKGNREAFLLALENAVDPSAHSVVTGKAPAGATLRLKKTFATPTWSGSVTDTLDTTLKVGASGTYTWHVNPSTRPVVKARQIRVIGSEPLKRQTYTGTTAPAQRTEHTFTVDRDADLMEVRLDWPTPDDLDLYVLRREADGTLTEVGRSTGSVGEKERVLLDAPARGEYVLRVENWASVTPGWELTASLYDATTEEVSGLVENWTLSCEKDGKVLQQVPVVVDRGQRVKADLKTCAQKWGKE
>NZ_CP022310.1|WP_142194199.1|3744127_3745444_-|hypothetical-protein
MRTATGRSRRTGAYALVTAAVLSATALGTTPASAASDALWVQSPEGATLSVTPGSYQELSFGLYHDNGDYHVANGVLGLDLSELAGVAEVTVPDHCFLNASGTAATCDIWEVGDIGGSYTGPQVTIGLRTLEGAPAGAELSIGHHGQAETDGPDGVLYTHWGSTPVTVESVPTPDLALTEPQPVGPLSPGDALTAPVTVTNNGDAAAHGFRLKLWTTYGLEAAATPAGCVRTPAAVDGGDMPVGLLDCTVDTVVEPGATVTLPEPPALTVASHALFERIDVSVQPLDGTQEQNQDDNFTSTSVTAHNTADFAVQGDEVTGAAGETVTATIGFRNRGPAWYGNIGSGDAVGTVTVAVPEGATVVSAPETCRAEGTAAYRCELPYWATPDDRIQFPFELRVDRVVPDATGAVTLHTSDRQTAHDPKPHNSHAVLALNPTD
>NZ_CP022310.1|WP_142232343.1|3745635_3748692_-|hypothetical-protein
MGRRAFVRGATAAAVSLTLAVGLGPLTAGAAHGATASAEVVVPATTSLLPGTSLLSAGPSGFLRHEPGHGLLWTGHDGTDTVVDASAGDPYGITATGAGSDVVARHDASARTVTLRNMASGEVDTVPLPEGHAYFSTLGSTVVTTAGTPGTDSVWHLLDLRDDGSVADRTVAGVPSGTYLWSSTPLGDARGQVVRYRKGDDMVTAWLDVAQGRLTTLPYEVQSWYYLVALTPTHLVWWYNGTLHVASRQNLDAPPRTLPVADVGQVLGMVGDTVLVSRYDSSLGRYDIGLPAWRVDAVPLDGSAPRTLLARTSRQAVPTVDGGLLVPGGADPGQWGVHLVEAAAGGGVTVRRVADAHPRKVVHPVSQLSLDQGRLTTVEENPVSQWDHLHTRDNGVAGSPTVGARTDRGRVAPESHGANRLRVLDTGDGRTVVSGHGTSAAEQPRLLGPSQSLPGTRIDSSRVYAYAAAAHGRFAALTRPYDSNGVAETRVVDLDTGRTVHTTTDTVRALWGTTLWVMSGNDTVVPVDLVTGQRGEPVWFGRGCLLDDFQAVGRWLLWTCVLNSEGQGVYDTVTKRNVTLVSGSGGERAKLGDGFVATVESGRLKVIDVRGGTPVAHTAGTFEWNSWDVDPYTGVIAQLRSDHSVRLTPSGVPVSALAQRDATVAASVDVKGGTVAWNPKWWLNKPAASWKLTVADKAGGAVVRTLSGGTARGVIGTSWNGKDGSGRLVRNGTYTWTLTATPADGQGAALTRTGTVRVTGAAAARRDFVASDGFGEMLTLNSTGGLTYHYGTGKGTFTGKRSGSGWPTTIRAVPYGDLSGDRCNDVLVRFSSGALRAYRPGCGAALTPSTPYTSLGTGWNQYDVLTSPGDLSGDGRPDLIARQASTGDVYLYKATSTGKLSARVKIRSAWTGYKKVLGAGDLNGDGHGDLLAQDRSNELWRYDGTASGQFKSRVKVFADWGASYNVVVGVGDITGDGRADIVSRDTSGAVWRNHGNGKGSFSGRTKITTGWQGYKGVF
>NZ_CP022310.1|WP_142232344.1|3749010_3750681_+|PucR-family-transcriptional-regulator
MVPDGTAGQGDPGGAGPTLERLLSVMGAGVLEPFTTPRGLTTAVEGVTVLDPLEPGQPRGQVLLAVGVDPQSAAAVDVVRHAAGAGAAAVVFGPGRNGRAPDALRTAAEDAGTAVLFRTAWCGWTELVGALRAGLVLSGVPADPAVAAVAPGDLNGLADAVAVLVGGAVTIEDVESRVLAYSSTAEDVDELRRLTILGRRVPPWRVAAMREAGFFRALWGSGDVIHRPAHGENPERLVVAVRAGGEILGSIWVAAAGGGDLPPHASDTLRSAARVAAGHLLHHRSHRAHARLVEDAARSLLDGRGSADVLAERTGIPAHGHCAVLAVRPGTSGKAEENGRLCALLAVRCGVDDLVPVVVPADQGALVLVGGLHQDLERAVDQVGRLGRSLVRQVADVFGPETRIGLGTVADTLAASHESRRSADLALRALLSPSETRTVAFASELAETIALHQMLDALLDALPGPDPAPGTPLARLVAHDARNGGGTLVQTLRAYLDHFGHVPDTARELGVHANSLRHRVSRLTEVSGLDLANPDARLLAHLQLRLLDRDGRKREG
>NZ_CP022310.1|WP_142232345.1|3750896_3752213_+|diaminopimelate-decarboxylase
MTTTVSGTHTAGRREQILRAAVQQGLLEPGTALLAGFVDLDGVEATVTSLHRAFPASLRTLHAFAAKANCLVPVLAELRRLGMGCEVASAGELDQALEAGFAPEQIVFDSPAKTRAELTRALSLGVAVNADSFQELARLDAILAAGPSASRLGVRVNPQVGAGSIGAMSTATATSKFGVPLEDEGNRQRLLEAYRERPWLTWVHTHVGSQGCPLDLIARGVAKAVEFAEEVNAHVGRRQVTGIDIGGGLPVNFDSDETTPGFDTYVAHLREHAPALFSGAYEIVTEFGRSVLAKNGFMAAYVEYTKTVGGRPIAITHAGAQVATRTVFAPDAWPLRIEAHDHLGRAKQGRPVPQDIAGPCCFAGDLLARERALPLLDVGDLVVVPDTGAYYFSTPFHYNSLPEPAVHGARVAADGSVTFEPLRPARSAHPAPVLAGGL

Crispr_ID: NZ_CP022310_11

• CRISPR_ID: NZ_CP022310_11
• CRISPR_location: 4111932-4112014
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_11

Consensus_repeat	Method
CTGCTCGTCGAGGGTGACCGGTG	CRISPRCasFinder

spacers of NZ_CP022310_11

>11.1|4111955|37|NZ_CP022310|CRISPRCasFinder
CCGCGCCCGCCATGTTCTGCACGAGGCGGGACACGGC

CRISPR arrays and Neighbor proteins around NZ_CP022310_11

CRISPR arrays

The CRISPR arrays of NZ_CP022310_11

>merge|NZ_CP022310|11|4111932-4112014|CRISPRCasFinder
CTGCTCGTCGAGGGTGACCGGTGCCGCGCCCGCCATGTTCTGCACGAGGCGGGACACGGCCTGCTCGTCGAGGGTGACCGGTG

>NZ_CP022310|11|9|4111932-4112014|CRISPRCasFinder
CTGCTCGTCGAGGGTGACCGGTG	CCGCGCCCGCCATGTTCTGCACGAGGCGGGACACGGC
CTGCTCGTCGAGGGTGACCGGTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142232517.1|4109997_4111269_-|CHAT-domain-containing-protein	unknown	unknown	gnl|CDD|378942
NZ_CP022310.1|WP_142232514.1|4105373_4106219_-|DUF3558-domain-containing-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142193860.1|4114200_4115301_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274934
NZ_CP022310.1|WP_142193866.1|4107807_4108584_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187604
NZ_CP022310.1|WP_142232524.1|4122235_4122850_-|hypothetical-protein	unknown	unknown	gnl|CDD|235906
NZ_CP022310.1|WP_142232523.1|4120559_4120973_-|DUF4396-domain-containing-protein	unknown	unknown	gnl|CDD|379568
NZ_CP022310.1|WP_142232520.1|4115997_4116717_+|response-regulator	unknown	unknown	gnl|CDD|223816
NZ_CP022310.1|WP_142193857.1|4116717_4118196_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NZ_CP022310.1|WP_142193867.1|4106434_4107628_+|RtcB-family-protein	unknown	unknown	gnl|CDD|376465
NZ_CP022310.1|WP_142232522.1|4119623_4120331_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226425
NZ_CP022310.1|WP_167530064.1|4104358_4105255_-|DUF3558-family-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142193865.1|4108678_4109014_-|YnfA-family-protein	unknown	unknown	gnl|CDD|235016
NZ_CP022310.1|WP_142232516.1|4109633_4110026_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232512.1|4102941_4104228_-|DUF2637-domain-containing-protein	unknown	unknown	gnl|CDD|378511
NZ_CP022310.1|WP_142193853.1|4121455_4122112_-|DUF305-domain-containing-protein	unknown	unknown	gnl|CDD|367619
NZ_CP022310.1|WP_142232515.1|4109134_4109617_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
NZ_CP022310.1|WP_142232519.1|4115297_4115924_+|oxidoreductase	unknown	unknown	gnl|CDD|274935
NZ_CP022310.1|WP_142232525.1|4122948_4123731_-|type-I-methionyl-aminopeptidase	unknown	unknown	gnl|CDD|238519
NZ_CP022310.1|WP_167530065.1|4107670_4107808_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232521.1|4118305_4119571_+|ArgE/DapE-family-deacylase	unknown	unknown	gnl|CDD|349890

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142232517.1|4109997_4111269_-|CHAT-domain-containing-protein	gnl|CDD|378942	pfam12770, CHAT, CHAT domain. These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins.	6.00634e-05
NZ_CP022310.1|WP_142193860.1|4114200_4115301_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274934	TIGR04036, family_protein, putative luciferase-like monooxygenase, FMN-dependent, CE1758 family. This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing > 60 % pairwise sequence identity, includes proteins from both species with and species without the ability to make coenzyme F420. Therefore, the like cofactor is FMN rather than F420. The presence of three members in Kineococcus radiotolerans SRS30216 and two in Saccharopolyspora erythraea NRRL 2338 suggest closely related (subfamily) rather than exactly conserved (equivalog) function. Gene neighborhoods around members are not conserved. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP022310.1|WP_142193866.1|4107807_4108584_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	6.8094e-92
NZ_CP022310.1|WP_142232524.1|4122235_4122850_-|hypothetical-protein	gnl|CDD|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.000791925
NZ_CP022310.1|WP_142232523.1|4120559_4120973_-|DUF4396-domain-containing-protein	gnl|CDD|379568	pfam14342, DUF4396, Domain of unknown function (DUF4396). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 167 and 310 amino acids in length.	1.89734e-34
NZ_CP022310.1|WP_142232520.1|4115997_4116717_+|response-regulator	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.73701e-84
NZ_CP022310.1|WP_142193867.1|4106434_4107628_+|RtcB-family-protein	gnl|CDD|376465	pfam01139, RtcB, tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyze the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage.	1.12207e-176
NZ_CP022310.1|WP_142232522.1|4119623_4120331_+|AAA-family-ATPase	gnl|CDD|226425	COG3910, COG3910, Predicted ATPase [General function prediction only].	8.54973e-60
NZ_CP022310.1|WP_142193865.1|4108678_4109014_-|YnfA-family-protein	gnl|CDD|235016	PRK02237, PRK02237, YnfA family protein.	5.09981e-48
NZ_CP022310.1|WP_142232515.1|4109134_4109617_+|MarR-family-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	5.97163e-12
NZ_CP022310.1|WP_142232512.1|4102941_4104228_-|DUF2637-domain-containing-protein	gnl|CDD|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	6.30999e-44
NZ_CP022310.1|WP_142193853.1|4121455_4122112_-|DUF305-domain-containing-protein	gnl|CDD|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	8.93674e-54
NZ_CP022310.1|WP_142193857.1|4116717_4118196_+|HAMP-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.46969e-48
NZ_CP022310.1|WP_142232519.1|4115297_4115924_+|oxidoreductase	gnl|CDD|274935	TIGR04037, predicted_flavoprotein, LLM-partnered FMN reductase, CE1759 family. This family represents a distinct clade within pfam03358. That family includes enzymes such as the NADH-dependent FMN reductase MsuE. Members of the present family regularly co-occur in genomes, typically as gene pairs, with members of TIGR04036, a probable FMN-dependent member of the bacterial luciferase-like monooxygenase (LLM) family. At least one member, RF|YP_001509627.1 from Frankia sp. EAN1pec, is fused to the LLM protein. The function of these gene pairs is unknown.	1.90901e-89
NZ_CP022310.1|WP_142232525.1|4122948_4123731_-|type-I-methionyl-aminopeptidase	gnl|CDD|238519	cd01086, MetAP1, Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.	4.75646e-105
NZ_CP022310.1|WP_142232521.1|4118305_4119571_+|ArgE/DapE-family-deacylase	gnl|CDD|349890	cd03895, M20_ArgE_DapE-like, M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases. Peptidase M20 family, uncharacterized protein subfamily with similarity to acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE) subfamily. ArgE/DapE enzymes catalyze analogous reactions and share a common activator, the metal ion (usually Co2+ or Zn2+). ArgE catalyzes a broad range of substrates, including N-acetylornithine, alpha-N-acetylmethionine and alpha-N-formylmethionine, while DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. Proteins in this subfamily are mostly bacterial, and have been inferred by homology as being related to both ArgE and DapE.	8.41141e-116

Protein sequences

>NZ_CP022310.1|WP_142232517.1|4109997_4111269_-|CHAT-domain-containing-protein
MNRAQPPDVVVRVVTTRDAATLEFTARRQGVPPLRVTLVGGDALHRARQELDAGLTRLKDDLRSLAVEDKDLDPAFQSLHGLGRTLLFILFGAQQRVLKGLQDFWRAALPWAANPALPPPLVECVGPQDSFLPLEFLPFLGIAPAPAVENRDGFVTACRTLVGFSCVVRRAMLPAPVRGGTTLRTGPQGRLPARYLYYEHLDGAMAELAWFTGPASAHVDLEGPYPHAADTGPGLAEQIFDPRLLLDGGRRELPDQLQHFACHCYTRSDDPLAAEIELSGAGRHSRTTLRTLGADLVTLGVTHDERDFDLPLVVMNACGSGRMRAQDAPSFPYLFLMNGNRGFIGTETEIPDDVAAAFSEALYERFLVRRLPLGRALLESRQHLLHSLGNPLGLAYAAYADPDLHIQPTTEEQPRVPARADHS
>NZ_CP022310.1|WP_142232516.1|4109633_4110026_-|hypothetical-protein
MSLPAQTTPDAPEPQPVPEAAGTVSVLGLEDTGQGGRTDRLSFRRAEEWRTARTEIPAEELRSRLHDFVTTMHGVLASLPQRAGEFQLDEVSFSAEVSAKGTVSLLGSGGELAGQAGITFTFTRRPDPAP
>NZ_CP022310.1|WP_142232515.1|4109134_4109617_+|MarR-family-transcriptional-regulator
MTASTREALLAELAVVSRRYMASYALFNQALADRLGLHPTDLQCLNLLTLEGGPVTTGRIAELTGLTTGSATRLVDRLERAGHVVRERDPDDRRLVLVATVPERAAEFTRVWDRVGGGWVALFDDLDDSQLALFIDHMRRTMEYGAEQAARLRSGAVRPY
>NZ_CP022310.1|WP_142193865.1|4108678_4109014_-|YnfA-family-protein
MLILRSAALFVLAALLEIGGAWLVWQGLREHRGWMWMAGGVLALGAYGFVATFQPDAHFGRVLAAYGGIFVAGSILWGVVADGYRPDRWDITGALVCLAGMAVIMWAPRNG
>NZ_CP022310.1|WP_142193866.1|4107807_4108584_-|SDR-family-NAD(P)-dependent-oxidoreductase
MATAAPSAAARIAVVTGASSGIGAATARRLAEAGYRVVLTARRKDRIEALAEQLTAAGHSATAYPLDVTDRAAVDEFATAFRTVGVLVNNAGGALGADPVATGDPEQWRTMYETNVLGTLNVTQALLPKLDASGDGTVVVVSSTAGHATYEGGAGYVAAKHAEHVLAETLRLEIVGRPVRVIEIAPGMVRTEEFALTRFGGDEEKAAKVYQGVAEPLTADDVADTITWAVTRPSHVNIDLLVVRPRAQASNTKVHRES
>NZ_CP022310.1|WP_167530065.1|4107670_4107808_-|hypothetical-protein
MTDGEKHRLALEKKRERYVWYYLAYFLFGIHIVAFVMIYAVTHAK
>NZ_CP022310.1|WP_142193867.1|4106434_4107628_+|RtcB-family-protein
MSYVELPGAKVPIRMWTDPATVEEGALQQLRNVATLPWIKGLAVMPDVHYGKGATVGSVIAMRGAVCPAAVGVDIGCGMSAVRTSLTANDLPGDLSRLRSKIEQVIPVGRGMHDDPVDPGRLHAFPTGGWDDFWSRFGGVADAVKFREERATKQMGTLGGGNHFVEVCVDTEGSVWLMLHSGSRNIGKELAEHHIGVAQKLPHNQGLVDRDLAVFVADTPQMAAYRNDLFWAQEYAKYNRSIMMALLKDVVRKEFKKAKPVFEPEISAHHNYVAEERYDGMDLLVTRKGAIRAGSGEYGIIPGSMGTGSYIVKGLGNAASFNSASHGAGRRMSRNAAKRRFSTKDLQEQTRGVECRKDSGVVDEIPAAYKPIEQVIDQQRDLVEVVAKLKQVVCVKG
>NZ_CP022310.1|WP_142232514.1|4105373_4106219_-|DUF3558-domain-containing-protein
MQRKAYVPGVAVLLAAVLAGCTGSPDDAGRADDSNPGSAGTATQAAQPGRYATLPEPCGVVEDRTLRELLPGIDELADETRRQKAYAGEATLTYDTDRTVGCRWKVESSEATDHLLIDLERIVSYDNAVSDDAQAEQLFAEKRTAAQLPEPKVTESGSPDTDASAEASSSPSGSPSASASGSASASASASDGTASPSAAPSDLQPRVLDDLGDEAFIDDELSSSGSTAKQRTVTVAFRTSNVIVTIEYAEQPMTVGVVPDSKEMQDRARKLASELADSLSD
>NZ_CP022310.1|WP_167530064.1|4104358_4105255_-|DUF3558-family-protein
MSEGTMQRRAQRDPRDPRDRRAKRLTRALVCASAVPVMLIAAGCSSDSGSDEGADKKADASASQSASPSPTVRAAAYKKLPEACEVLSEKTLDDLAPKAKKGKEGSSDDISSRASCSWSSLENNGVDGSQFRWLNVSLLRFDSDTTRGPGDELAGKYYDKQVRDAQAAEGAKGAETEPVTDTGDEATAVRYDLKKKEGTFKQQTVVVRVENVVVTLDYNGAGLAGDETPDADDLMKDLRKAAKEAVASVAKANGSATASGSPSASASKSASASASKSASASASKSASEPASESAAEKS
>NZ_CP022310.1|WP_142232512.1|4102941_4104228_-|DUF2637-domain-containing-protein
MAGPLQLTRMHRVLIGVVVTGAVIIAGIGFAGSYAAVRELALKKGFGDFSYVFPIGIDAGICVLLALDLLLTWIRIPFPLLRQTAWLLTAATIAFNGAAAWPDPLGVGMHGVIPVLFVVSVEAARHAIGRIADITADKHMEGVRLTRWMLSPVPTFLLWRRMKLWELRSYEQVIKLEQERLVYQARLRSRFGRAWRRKAPVEALMPLRLAKYGVPLAETAPAGLAAAGIEPALIPPPPEVAAGDRSSHAGRVGAAAPAGEQRLELEGNQGAGFVQEPSPEQNPWLHARDPHTVEYHGGYDPTYDPDEEYARWYAEQQQAEQYQDQYQEEPPVQEPAPEETGSFPIPVVPGGRTRELGEGGGTAASDPDEESFYQVFRQSIDGSYPTPRVLGDNIQATYGTTLSSGALKDLVERFQKRHTAELEEDHIA
>NZ_CP022310.1|WP_142193860.1|4114200_4115301_+|LLM-class-flavin-dependent-oxidoreductase
MQFGIFSVGDVTPDPTTGRTPTERERIKAMVAIALKAEEVGLDVFATGEHHNPPFVPSSPTTMLGYIAARTERLILSTSTTLITTNDPVKIAEDFAMLQHLADGRVDLMMGRGNTGPVYPWFGQDIRQGINLAIENYALLHRLWREDVVNWEGKFRTPLQGFTATPRPLDGVPPFVWHGSIRSPEIAEQAAYYGDGFFHNNIFWPADHTKRMIELYRARYAHYGHGTPEQAIVGLGGQVFMRKNSQDAVREFRPYFDVAPVYGHGPSLEEFTEQTPLTVGSPQQVIDKTLSFREYAGDYQRQLFLMDHAGLPLKTVLEQLDLLGEEVVPVLRKEFAKDRPADVPDAPTHSSLLATAKRAEKEGARA
>NZ_CP022310.1|WP_142232519.1|4115297_4115924_+|oxidoreductase
MRLVVVSAGLSVPSSTRLLGDRLAAAAAPAATAPEPAPADVRVIELRDLAVEIAHTFTNGFPAPALADAFDAVFGADGLIVVTPVFSASYSGLFKSFFDALGVTDPDALTGKPVLIAATGGTARHSLVLDHALRPLFSYLKAVVVPTGVYAAAEDWGAEGLDGRIERAAGELAALMAGSPTVRPAPRRDSFEEVVPFEQRLAALRPGG
>NZ_CP022310.1|WP_142232520.1|4115997_4116717_+|response-regulator
MPHTVLLAEDDRAIRNALERALTLEGYRVTAVADGVEALAQAHRSRPDVLVLDVMMPGIDGLQVCRVLRAEGDRTPVLMLTALVETADRIAGLDAGADDYVVKPFDVEEVFARLRALLRRAAPPAPAPAPAPEPEPDTSGRFLEAAGLRMDPQARRAWRGARELELTRTEFELLELLIRHAGVVLEHSTIYDRIWGYDFGPGSKNLAVYVGYLRRKLDEPGAPQLIHTVRGVGYVLREG
>NZ_CP022310.1|WP_142193857.1|4116717_4118196_+|HAMP-domain-containing-protein
MFRRAAAGGPGHAHGRSVPRRRLRLLSLGTTFAVAFAAVTATVTVLVGILSYNAAARLVRVDQLSVFHEVVQDVRAEVRENRMAPVDFSSAAPGHDLVRPARTDVQVLGPDGSVYDPGDPGLPVVDADRRIAGAATAGQVVEHADVDVGDDVYRVATVALGGGRGAVQIAQEFSNTEDLLRALQRRTLILMAAVVVGAGLFGWWLARRITRRLVVLTNAAEDVARTRRLGIQVPVAGYDEVGRLGRAFDRMLGRLAQSEEDQRRLVQDAGHELRTPLTSLRTNISLLRRIDELPPGTREELVADLTQEARELTDLVNELVDLAAGQSDTEPPQRVDLAEIAEDVAGLARRRTGREIVVSACGDTTTDGRPGMLTRALSNLVENAVKFDRDSRAPVEIRVAGPARPGTVRVEVRDRGPGIADDDLTRVFDRFYRAADARSLPGSGLGLSIVREVALAHGGAPYAFRRDGGGTVTGFTVGGAAAGAGTDSPAEG
>NZ_CP022310.1|WP_142232521.1|4118305_4119571_+|ArgE/DapE-family-deacylase
MLTDEEQAALAAVDEEALGRTLLELVAVPSVTGSAAESELQHLLAGRLERLGTEVDLWPLDLPALRADPDFPGTEAPREEAWGLVGTTPDGGDGPTLILQGHVDVVPPGDPAAWHGDPFVPRVTGDLVHGRGTCDMKAGLAAHLAALAAIRTAGIRLRGRVAVHCVVGEEDGGLGAFGTLRRGHHGDACVIAEPTAGTLITANAGALTFRLAVPGRAAHGSAREQGVSAVDAYLPLHRALAALETERNRDPAPLLTEYPIPYGLSVGTLRAGDWASSVPDLLVAEGRYGVRLGEDPAEARAAFEECVARACAADPWLWDHPATVSWPGGQFASGRLPEGHPLADVVGTAHADATGSARPRQRGATYGSDLRHYAGAGIPTLQYGPGDIAVAHSEREHVNLREVAQAARTLVLTVLRTVGTK
>NZ_CP022310.1|WP_142232522.1|4119623_4120331_+|AAA-family-ATPase
MIIERVYVHGGGCDEGEWPWSVPCVRQLLDGGLRFTAPVTFVVGENGSGKSTLVEALAEGFGLDPWGGSHEWRYASHRAKSVLGERIRFDAAPRGRRMMASWSARQGFFLRAETALDALGREGLAPDVRSHGEGFLAAFRDKFLRPGLYVLDEPEAALSFSSCLELIGHIDQLTRAGAQVVCATHSPLLTALPGADIVEVGDHGIRRTSWNDLALVDHWRRYLTDPSAYLRHVLD
>NZ_CP022310.1|WP_142232523.1|4120559_4120973_-|DUF4396-domain-containing-protein
MKATLHCLTGCAIGEILGMVIGTALLWDNVPTMALAITLAFIFGYSFTLFAVVRAGVSLKAAIKVALAADTVSIAVMELVDNAIIALTPGAMDAHLSDGLFWSALLGGFAVAFVITTPVNKWMIGRGKGHAVVHAYH
>NZ_CP022310.1|WP_142193853.1|4121455_4122112_-|DUF305-domain-containing-protein
MIRKRSLLRRTAAVVTAGAAALVLAACGGDGDDTGAAGHGGHHASASESASTPASPSASQGRHNAADVAFAQGMIPHHRQAVEMADLAPDRARSAEVKKLAADIKKAQAPEIRTLSGWLTSWGEEVPAEGAPNHSGHGAHGMAGMMTDEEMGELEGLSGEAFDTAFMEMMIKHHEGAVEMAETEQADGAHAPARKLAARIIASQSAEIEQMNEFLGKG
>NZ_CP022310.1|WP_142232524.1|4122235_4122850_-|hypothetical-protein
MTRSTSTTSSRPAGRLLVLLVLSVLAGVLGMHGLAPGGVPTPHSSGPHAGGTYTGGPYAAATDASGPHAAATDAGAAHAAAVHAGIAHTGPVHAGPVHSGAAHSVTTHSGGPHAYGSHDSVAPAPDGVPHANGGCAHTDGGSGHLDHADGACAAAGTGSTYTPPAQAGAVVDAPAAAPAVTAAAVSPRDGRAPPDLSELQLLRI
>NZ_CP022310.1|WP_142232525.1|4122948_4123731_-|type-I-methionyl-aminopeptidase
MIEILNPTLLARARDTGALVADILETLRSRSAVGTNLLEIDRWAKEMIVEAGAQSCYVDYEPSFGRGPFGHYICTAVNDAVLHGRPHDYTLTDGDLLTLDLAVSLDGVAADAAISFLVGDARPPESVALISATERALAAGIAAAGPGARIGDISHAIGTVLSEAGYRINTEFGGHGIGSTMHQDPHVANTGRPGRGYKLRPGLLLALEPWVMADTARLVTDADGWTLRSATGCRTAHSEHTIAITEDGAEILTLPERARP

Crispr_ID: NZ_CP022310_12

• CRISPR_ID: NZ_CP022310_12
• CRISPR_location: 4265769-4265863
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_12

Consensus_repeat	Method
CGCCCCGAGCCCGTACGCGCACC	CRISPRCasFinder

spacers of NZ_CP022310_12

>12.1|4265792|49|NZ_CP022310|CRISPRCasFinder
CGAGCCCGTGGGCCGCCCCGAGCCCGTACGCGCACCGGAGCCCGTGGGC

CRISPR arrays and Neighbor proteins around NZ_CP022310_12

CRISPR arrays

The CRISPR arrays of NZ_CP022310_12

>merge|NZ_CP022310|12|4265769-4265863|CRISPRCasFinder
TCGCCCGGATCCGTACGCGCACCCGAGCCCGTGGGCCGCCCCGAGCCCGTACGCGCACCGGAGCCCGTGGGCCGCCCCGAGCCCGTACGTGCACC

>NZ_CP022310|12|10|4265769-4265863|CRISPRCasFinder
TCGCCCGGATCCGTACGCGCACC	CGAGCCCGTGGGCCGCCCCGAGCCCGTACGCGCACCGGAGCCCGTGGGC
CGCCCCGAGCCCGTACGTGCACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142193741.1|4274366_4275734_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|379374
NZ_CP022310.1|WP_142232597.1|4271110_4273033_-|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	unknown	unknown	gnl|CDD|274738
NZ_CP022310.1|WP_142232596.1|4268697_4269552_-|NAD(P)H-binding-protein	unknown	unknown	gnl|CDD|187578
NZ_CP022310.1|WP_142232598.1|4275838_4277104_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP022310.1|WP_142193755.1|4256181_4256661_-|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|381605
NZ_CP022310.1|WP_142193742.1|4273206_4273878_-|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_CP022310.1|WP_142234157.1|4262479_4263064_-|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl|CDD|376808
NZ_CP022310.1|WP_167530069.1|4261867_4262467_+|hypothetical-protein	unknown	unknown	gnl|CDD|177020
NZ_CP022310.1|WP_142193739.1|4277322_4277733_+|NAD(P)H-quinone-oxidoreductase-subunit-3	unknown	unknown	gnl|CDD|169084
NZ_CP022310.1|WP_161175054.1|4266907_4267381_-|hypothetical-protein	unknown	unknown	gnl|CDD|380093
NZ_CP022310.1|WP_142232593.1|4264509_4265016_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232590.1|4258650_4259874_+|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl|CDD|225390
NZ_CP022310.1|WP_142232595.1|4267448_4268492_-|EamA-family-transporter-RarD	unknown	unknown	gnl|CDD|225510
NZ_CP022310.1|WP_142232589.1|4255345_4256218_+|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl|CDD|369792
NZ_CP022310.1|WP_142193754.1|4257392_4258403_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|173833
NZ_CP022310.1|WP_142234156.1|4260044_4260965_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_CP022310.1|WP_142193744.1|4270059_4271118_-|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	unknown	unknown	gnl|CDD|237006
NZ_CP022310.1|WP_142232591.1|4260951_4261821_+|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|224196
NZ_CP022310.1|WP_142234158.1|4263319_4264501_-|amidase	unknown	unknown	gnl|CDD|223232
NZ_CP022310.1|WP_142193745.1|4269644_4270025_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142193741.1|4274366_4275734_-|sensor-histidine-kinase	gnl|CDD|379374	pfam13796, Sensor, Putative sensor. This family is often found at the N-terminus of proteins containing pfam07730 and pfam02518. The N-termini of proteins containing these two domains often function in stimulus sensing.	1.88651e-43
NZ_CP022310.1|WP_142232597.1|4271110_4273033_-|2-oxoacid:acceptor-oxidoreductase-subunit-alpha	gnl|CDD|274738	TIGR03710, OAFO_sf, 2-oxoacid:acceptor oxidoreductase, alpha subunit. This family of proteins contains a C-terminal thiamine diphosphate (TPP) binding domain typical of flavodoxin/ferredoxin oxidoreductases (pfam01855) as well as an N-terminal domain similar to the gamma subunit of the same group of oxidoreductases (pfam01558). The genes represented by this model are always found in association with a neighboring gene for a beta subunit (TIGR02177) which also occurs in a 4-subunit (alpha/beta/gamma/ferredoxin) version of the system. This alpha/gamma plus beta structure was used to define the set of sequences to include in this model. This pair of genes is not consistantly observed in proximity to any electron acceptor genes, but is found next to putative ferredoxins or ferredoxin-domain proteins in Azoarcus sp. EbN1, Bradyrhizobium japonicum USDA 110, Frankia sp. CcI3, Rhodoferax ferrireducens DSM 15236, Rhodopseudomonas palustris BisB5, Os, Sphingomonas wittichii RW1 and Streptomyces clavuligerus. Other potential acceptors are also sporadically observed in close proximity including ferritin-like proteins, reberythrin, peroxiredoxin and a variety of other flavin and iron-sulfur cluster-containing proteins. The phylogenetic distribution of this family encompasses archaea, a number of deeply-branching bacterial clades and only a small number of firmicutes and proteobacteria. The enzyme from Sulfolobus has been characterized with respect to its substrate specificity, which is described as wide, encompassing various 2-oxoacids such as 2-oxoglutarate, 2-oxobutyrate and pyruvate. The enzyme from Hydrogenobacter thermophilus has been shown to have a high specificity towards 2-oxoglutarate and is one of the key enzymes in the reverse TCA cycle in this organism. Furthermore, considering its binding of coenzyme A, it can be reasonably inferred that the product of the reaction is succinyl-CoA. The genes for this enzyme in Prevotella intermedia 17, Persephonella marina EX-H1 and Picrophilus torridus DSM 9790 are in close proximity to a variety of TCA cycle genes. Persephonella marina and P. torridus are believed to encode complete TCA cycles, and none of these contains the lipoate-based 2-oxoglutarate dehydrogenase (E1/E2/E3) system. That system is presumed to be replaced by this one. In fact, the lipoate system is absent in most organisms possessing a member of this family, providing additional circumstantial evidence that many of these enzymes are capable of acting as 2-oxoglutarate dehydrogenases and.	0
NZ_CP022310.1|WP_142232596.1|4268697_4269552_-|NAD(P)H-binding-protein	gnl|CDD|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	6.48406e-83
NZ_CP022310.1|WP_142232598.1|4275838_4277104_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.39131e-31
NZ_CP022310.1|WP_142193755.1|4256181_4256661_-|transglycosylase-SLT-domain-containing-protein	gnl|CDD|381605	cd13402, LT_TF-like, lytic transglycosylase-like domain of tail fiber-like proteins and similar domains. These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.78189e-30
NZ_CP022310.1|WP_142193742.1|4273206_4273878_-|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.97107e-39
NZ_CP022310.1|WP_142234157.1|4262479_4263064_-|NAD(P)H-dependent-oxidoreductase	gnl|CDD|376808	pfam02525, Flavodoxin_2, Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.	2.59939e-10
NZ_CP022310.1|WP_167530069.1|4261867_4262467_+|hypothetical-protein	gnl|CDD|177020	CHL00081, chlI, Mg-protoporyphyrin IX chelatase.	0.00224696
NZ_CP022310.1|WP_142193739.1|4277322_4277733_+|NAD(P)H-quinone-oxidoreductase-subunit-3	gnl|CDD|169084	PRK07756, PRK07756, NADH-quinone oxidoreductase subunit A.	3.35395e-34
NZ_CP022310.1|WP_161175054.1|4266907_4267381_-|hypothetical-protein	gnl|CDD|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	4.57718e-27
NZ_CP022310.1|WP_142232590.1|4258650_4259874_+|outer-membrane-lipoprotein-carrier-protein-LolA	gnl|CDD|225390	COG2834, LolA, Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane].	2.28102e-11
NZ_CP022310.1|WP_142232595.1|4267448_4268492_-|EamA-family-transporter-RarD	gnl|CDD|225510	COG2962, RarD, Predicted permeases [General function prediction only].	4.69184e-100
NZ_CP022310.1|WP_142232589.1|4255345_4256218_+|Cof-type-HAD-IIB-family-hydrolase	gnl|CDD|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	2.80253e-63
NZ_CP022310.1|WP_142193754.1|4257392_4258403_+|polyprenyl-synthetase-family-protein	gnl|CDD|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	1.33964e-90
NZ_CP022310.1|WP_142234156.1|4260044_4260965_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.06574e-96
NZ_CP022310.1|WP_142193744.1|4270059_4271118_-|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta	gnl|CDD|237006	PRK11867, PRK11867, 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed.	1.55498e-172
NZ_CP022310.1|WP_142232591.1|4260951_4261821_+|ABC-transporter-permease-subunit	gnl|CDD|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	7.40449e-09
NZ_CP022310.1|WP_142234158.1|4263319_4264501_-|amidase	gnl|CDD|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	7.06627e-68
NZ_CP022310.1|WP_142193745.1|4269644_4270025_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	7.22821e-32

Protein sequences

>NZ_CP022310.1|WP_142232593.1|4264509_4265016_-|hypothetical-protein
MRTGMRQGPEIWIRGPVAVPETAPPEPAHPRATARAFSWVGLHGGAGVSTLAAVYGGHDSGRAWPGPADPRSVLLVARTHAAGLDAVVPAMEVFRRGEAPHGLDLNAVVLVADAPGRLPRPLVQRLRTVEALIDVYRVPWVPEWRLGDLTGRPPRETEPLARLTGGPR
>NZ_CP022310.1|WP_142234158.1|4263319_4264501_-|amidase
MPGVRRRGRYGAASAEEIAAAVRERRLRAVDVVAEALERIGRADPVLCAFLEVWGDQALRRAGELDARVAGGAAEGGALPLAGVPVAVKGRAGLRAAGPLLAAGCVAVGATSVPGPGTPWQTWGLGQHGVTVNPWRADRTPGGSSAGAAVAVAAGLVPLATGSDGAGSVRIPAAWCGVVGLKVTAGRLPSPDRTGLATPGVLTRTAADTAAWWRVVTRQTVDDAAPVTFPVTAVWSPDLGFAAPDPEPVALARAAADRLVDAGVVRLVRPPAPPLLLDPAPAWLALRTPGADLAEARRIRAENDRRLDRLFSGADLLLTPTTPTPPHGHDGPGDVYSTALTWAFNVSGHPALSMPAGFGADGCPAGLQLVAGPGREALLLAAAQEAELRTAAA
>NZ_CP022310.1|WP_142234157.1|4262479_4263064_-|NAD(P)H-dependent-oxidoreductase
MTRRFLFVLGSARADGNTELLARRAAEQLPPEVEQQWIDLTADPLPDFEDLRHDSDHVRPTEGPVAHVLDATVAATDVVIASPLYWYSVSAHTKRYLDHWSGWLRTPGLDFKATMAGRTLWGVTALAHEEQEVADPLIGTLNNSAAYMGMRFGGVLLGNGSKPGDVLRDTEALARAKTFFAQDAPLARFPYEAG
>NZ_CP022310.1|WP_167530069.1|4261867_4262467_+|hypothetical-protein
MGNSRAYPVFRTTDAAEAYRQAKRLCALLEHIDDATWLFAVMRTPSEVRAMAELVPEGSFEYDDFRTDPATGDLLRFDLDVTTLDDAELATHLPLSFTEDVVRGDGTVEERFLAALGEGVAAMEWNGRWPDDPEIDSLGHWNHDGVQIVFHGDEAQYGDTWTEDHTVFVHVTKYGDPERAQKLAAHIGSEVLGEEQLGW
>NZ_CP022310.1|WP_142232591.1|4260951_4261821_+|ABC-transporter-permease-subunit
MSRAETAGRVSPLWTFGLFRSELLTTFRRWRTLALLGVLAAVPVLVGVAVRIETGGDGSAGGGGGGGPAFISQITNNGLFLVFTALAVTLPFFLPMAVGVVAGDAVAGEANAGTLRYLLVAPAGRSRLLLTKYATVMAFCLVATLVVALSALITGALLFPLGDPTTISGTRIGFAEGLVRALLIALVVALSLIGVAALGLFVSTLTNSGIAAMATTVGLLTTVQILDQIPQLHALHPYLFSHHWLSFADLMREPVYWDDLTKNLGLQALYAAVFGSAAWARFTARDITA
>NZ_CP022310.1|WP_142234156.1|4260044_4260965_+|ATP-binding-cassette-domain-containing-protein
MVTRGLTKRYRGGQLAVDGLHLTVPAGSVFGFLGPNGSGKTTTIRMLMGLIEPTSGTAHVLGRPMPRSARAVLPHVGALIEGPALYGFLSGRDNLLRYDAADPTADPRTRHARVAAALDRVGLTAAAGKKAKAYSLGMKQRLGLAAALLRPRRLLVLDEPTNGLDPQGMREIRTLVRELASDGTTVFLSSHLLDEIEQVCTHAAVMARGRLITQGPVAELSAGARGRLAVTTPDAADAARVLKEQGVADVVVAEERVSGEVPERDLAEVNAALVAAGVRVRGFGVERASLEDAFVALTGEGFDVAG
>NZ_CP022310.1|WP_142232590.1|4258650_4259874_+|outer-membrane-lipoprotein-carrier-protein-LolA
MAPYESDDMTTAGEVDEPRSRRRRAARYVVPVTVMGVAAATIGLVPALADSGDPDLPEITAAQLIEKIAASDVEQLSGTVKITTDLGLPDLGGLEDSLASGAAGSGAGEDGSSADPSAKLTELASGTHTLRVAADGPDRQKLSLLENAAEYSLIHNGKDVWGYDSKSNAVHHSTVEESAKDREHQPPATPKDFAEEALKAVDDTTSVTVDGTAQVAGRDAYKLVVKPRQSGSTVGAISIAVDHRTGMPLKFTLTPASGGAAVVDVGFTEVSFDKPAASTFEFTPPKGAEVTEDSAPEHGREHSAKPEKAPKSQEDLAKGLDGLKMLGEGWNSVATFDSGSEGGLPTGEAGGDLDGFLGSLGDQVKGDFGTGTVFSTRLINALITDDGTVYVGAVTKDALVKAADAGK
>NZ_CP022310.1|WP_142193754.1|4257392_4258403_+|polyprenyl-synthetase-family-protein
MTVVGPFGLSVRDQALQADVQAGLTAVEEGLLEATKSEVPFITEAAQHLVRAGGKRFRPLLVMLAAQFGDPYAPGVVPSAVVVELTHLATLYHDDVMDEADVRRGVPSANTRWGNSVAVLTGDFLFARASHILADLGPEAVRVQAEAFERLVTGQILETAGPQDGRDPVEHYLDVLGGKTGSLVAVACRFGAMMSGADETVVHVLTQYGERLGVAFQLADDVLDIASDSHESGKTPGTDLREGIATLPVLRLRERADRLGRADDLALCELLDSDLTDDTRHAEALRRLRVHPALEQARRDTVRYAEEARAALAPLRECDAKAALVQLCDAVVHRAG
>NZ_CP022310.1|WP_142193755.1|4256181_4256661_-|transglycosylase-SLT-domain-containing-protein
MPAHGQHRRARNRRLARSLAVAGTGVAVVALPLFGATSASANTTASTTAPTAYPDNLDGWIREALSVMAQHGIPGSYEGIHRNIMRESSGNPAAINLWDSNAVAGTPSKGLLQVIDPTFQAYHVPGTPFDPYDPVANITAACNYAADRYGSIDNVFGAY
>NZ_CP022310.1|WP_142232589.1|4255345_4256218_+|Cof-type-HAD-IIB-family-hydrolase
MAAPTAYSLIATDLDGTLLRGDDTLSDRSLAALARAARAGARHLVVTGRPAPRVRPLLDDLGSTGLAVCGQGAQVYDAGANRLLWSVTLDRELAETALGKIEAEVGEVYAAVDQDGVDGLTLIEPGYLMPHPTLPAVRVERRRDLWERPISKVLLRHPRLSDDALAAAARAVVGSLATVTMSGPGTVELQPCGVTKATGLALAAEHLGLSPKGAIAFGDMPNDIPMFDWAARGVAMANAHPELKAVADEVTTSNEDDGVAVVLERLFGGPAVLGRQRSAQYAPKTLSIEP
>NZ_CP022310.1|WP_161175054.1|4266907_4267381_-|hypothetical-protein
MTQTPTPPTPVHWKIVIDSADPHAQADFWAAALRYVVEDNSALIGKLLAAGAVPADLTVESHGRHAWRDLAAVRHPDDPYDEETGTGRGRRLLFQRVPEAKTVKNRLHLDLHPGAGRREEELARLERLGARMLRRVEEPSGGWLVMADPEGNEFCLH
>NZ_CP022310.1|WP_142232595.1|4267448_4268492_-|EamA-family-transporter-RarD
MTGKSAAEGRIGLLNGFAAYGMWGLVPLFWPLLKPSGAVEILAHRMVWSLLFVAAALLVVRRWAWLGELLRQPRRLALVAVAAAVITVNWGVYIWSVNSGHVVEASLGYFINPLVTIAMGVLLLKERLRPVQWAAVGVGASAVVVLTVGYGRPPWISLCLAFSFATYGLVKKKVNLGGVESLAAETAIQFLPALGYLLWLGAQGESTFAVEGTGHALLLAATGIVTALPLVCFGAAAIRVPLSTLGLLQYLAPVFQFLLGILYFKEAMPPERWAGFALVWLALVLLTWDALRTARRTARTLAGTSRNGTTGVVAGSGGAVAAGTAGAVRPSEPVAAAAEADPLEARP
>NZ_CP022310.1|WP_142232596.1|4268697_4269552_-|NAD(P)H-binding-protein
MGIIVTGATGKLGRLVVEQLLEKVPAEQVTAVVRSAGKAADLAERGARIAVADYNAPETFDGLFAAGDKVLLISGNEVANDRVAQHRVVIDAAKAAGVALLAYTSAPGTLSAALADDHRGTEEALRDSGVPYVLLRNGWYHENYTENLAPVLAHHAVVAAAGEGRVSSASRADYAAAAVAVLTGEGHANATYELGGDVAWSFAEYAAELSRQTGETIAYRRVTVEELTGILTGAGIPEPVAAVLAGVDTSIEKGELVVDSGDLSRLIGRPTTPLAEAVAAALAN
>NZ_CP022310.1|WP_142193745.1|4269644_4270025_+|helix-turn-helix-transcriptional-regulator
MAVSDGGRRSEAEALCPHRLVLEHVTSRWGVLVLIQLLERPYRFSELRRAIGRVSEKMLTQTLQTLERDGLVHRDAKPVIPPRVDYSLTALGREAAEQVRGLALWTRQRMDDVLAARQAYDGARTR
>NZ_CP022310.1|WP_142193744.1|4270059_4271118_-|2-oxoacid:ferredoxin-oxidoreductase-subunit-beta
MTDTNALLQLVPKAEGRQSMRDFKSDQEVRWCPGCGDYAVLAAVQGFMPELGLARENIVFVSGIGCSSRFPYYMNTYGMHSIHGRAPAIATGLATSRRDLSVWVVTGDGDALSIGGNHLIHALRRNVNLKILLFNNRIYGLTKGQYSPTSELGKITKSTPMGSLDAPFNPVSLALGAEASFVARTVDSDRKHLTEVLRQAADHPGTALVEIYQNCNIFNDGAFEVLKDRQQAEEAVIRLEHGQPIRFGTDQTKGVVRDPATGDLKIVPVTPDNEADILVHDAHSTSPTTAFALSRLADPDTLHNTPIGVFRSVDRPVYDTLMADQLDTAVEQHGKGDLAALMTGGDTWTVVG
>NZ_CP022310.1|WP_142232597.1|4271110_4273033_-|2-oxoacid:acceptor-oxidoreductase-subunit-alpha
MTSQVSSPAEQADGAVVGEQRKAAGEKDVRRLDRVIIRFAGDSGDGMQLTGDRFTSETASFGNDLSTLPNFPAEIRAPAGTLPGVSSFQLHFADHDILTPGDAPNVLVAMNPAALKANIGDLPRGAEIIVNTDEFTKRAMQKVGYDSSPLDDGSLDGYHLHPVPLTTLTVEALKDFDLSRKEAERSKNMFALGLLSWMYHRPTEGTEKFLRSKFAKKPDIAAANIAAFRAGWNFGETTEDFAVSYEVAPAVFPVGRYRNISGNLALSYGLIAASRQADLPLYLGSYPITPASDILHELSRHKNFGVRTFQAEDEIAGIGAALGAAFGGSLAVTTTSGPGVALKSETIGLAVSLELPLLIVDIQRGGPSTGLPTKTEQADLLQAMYGRNGEAPVPVVAPRTPADCFDAALEAARIALAYRTPVFLLSDGYLANGSEPWRIPDPDELPDLTVQFAQGPNHTLDDGTETFWPYKRDPQTLARPWALPGTPGLEHRIGGIEKQDGTGNISYDPANHDFMVRTRQAKIDGIDVPDIEVDDPDNARTLVLGWGSTYGPITAAVRRLRATGESIAQAHLRHLNPFPHNLGDVLTRYERVVVPEMNLGQLATLIRAKYLVDARSYNQVNGMPFKAQQLATALKEAIDD
>NZ_CP022310.1|WP_142193742.1|4273206_4273878_-|response-regulator
MEDRVRVVIAEDSVLLREGLTRLLTDRGHEVVAGVGDGDALIKTITELDGQDLLPDVVVADVRMPPTHTDEGVRAAVQLRKAHPGVGVLVLSQYVEERYATELLAGSSRGVGYLLKDRVADVREFVDAVVRVARGGTALDPEVVAQLLGRSRKQDVLAGLTPREREVLGLMAEGRTNSAIARQLVVSDGAVEKHVSNIFMKLGLSPSDGDHRRVLAVLTYLNS
>NZ_CP022310.1|WP_142193741.1|4274366_4275734_-|sensor-histidine-kinase
MATDYGQGYGLDTAPGHPGGAAGERRHRMPAALRAPVEGRTWRELAFVLLSLPISVLLFVYAVTMVSLGAGLLVTFLGVPVLAAALAGCRGFGALERARARGLLGLEVGDPEPLRMKRQGLMGWVGAVLKSGASWRALLYAVLHLPWAVLSFVVTVNLWLLGWSLLTYPLWFWVFPVYAGQDGLQLYGDGRHSIYLDNPFEITVTALVGLLFTLAVPWIVRALTTVDRLMVHGLLGPSRLATRVVELESDRGVVVDTAAADLRRIERDLHDGAQARLVALAMDLGLAKEKLRENPQAAARMVDEAHGEVKTALQELRDLARGIHPAVLTDRGLDAALSSVASRCTVPVQVEVDLAERPAPAIEGIAYFTVSELLQNVSKHARATWAAVEVWRTENRLMLQVVDNGVGGAEVTAGSGLAGLTERLDAVDGILVVDSPAGGPTRVTAELPWRAERAR
>NZ_CP022310.1|WP_142232598.1|4275838_4277104_-|sensor-histidine-kinase
MTEPFPPPGPPATAVPEPAGPDDRPPPARFAYDAHTWKEIAHLLANLPVSLIGFVYVVTTLFTGLGLTVTVIGFPVLAAALTGARLLGRLERARARKLLGVRVDEPSRLPSRGADGFWPRLWMAVKDPVAWRTVLYQLIRLPWGVLTFTVALTGLFVLWPVLPFVVRGLANADRAMVRGLLSPSDELERRIAELESDRGVVVDTAAADLRRIERDLHDGAQARLVNLAMGLGLAKEKLLEDPDVAATMVEEAHGEVKLALQELRDLARGIHPAVLTDRGLDAALSSVASRCTVPVKVTVDLDERPAAAIEGIAYFTVSELLQNVSKHSGARTAAVDVWRSEDRLFMQVWDDGGGGASLDGGSGMRGLADRLGAVDGLFVVDSPEGGPTTVTAELPWRDRSDAPDGGAGPAQGASVRGRGWG
>NZ_CP022310.1|WP_142193739.1|4277322_4277733_+|NAD(P)H-quinone-oxidoreductase-subunit-3
MREPTVVDATVVVAADYFESYSVVGLLGVVGLLFVAVAFGAGRLLRPVVPTPEKLMTYECGVDPVGEGWAHTQVRYYVYAFLYVIFAVDSIFLFPWATVFAADGYGATTLVEMFIFLGFLAVGLLYAYKKGVLTWT

Crispr_ID: NZ_CP022310_13

• CRISPR_ID: NZ_CP022310_13
• CRISPR_location: 4549070-4549177
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_13

Consensus_repeat	Method
CCGGACGCTGACCGGCGGACGTCCGGG	CRISPRCasFinder

spacers of NZ_CP022310_13

>13.1|4549097|54|NZ_CP022310|CRISPRCasFinder
ACGGCCGAGGACGGCCGGGGACGCCCGGAGACGTCGGGGGGCCGTTCTGCCTAT

CRISPR arrays and Neighbor proteins around NZ_CP022310_13

CRISPR arrays

The CRISPR arrays of NZ_CP022310_13

>merge|NZ_CP022310|13|4549070-4549177|CRISPRCasFinder
CCGGACGCTGACCGGCGGACGTCCGGGACGGCCGAGGACGGCCGGGGACGCCCGGAGACGTCGGGGGGCCGTTCTGCCTATCCGGACGCTGACCGGCGGGACGTCCGG

>NZ_CP022310|13|11|4549070-4549177|CRISPRCasFinder
CCGGACGCTGACCGGCGGACGTCCGGG	ACGGCCGAGGACGGCCGGGGACGCCCGGAGACGTCGGGGGGCCGTTCTGCCTAT
CCGGACGCTGACCGGCGGGACGTCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142194861.1|4547311_4548181_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	unknown	unknown	gnl|CDD|234708
NZ_CP022310.1|WP_142232710.1|4556750_4557062_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142194858.1|4543214_4544960_-|phospholipid-carrier-dependent-glycosyltransferase	unknown	unknown	gnl|CDD|224839
NZ_CP022310.1|WP_142232708.1|4553252_4555250_+|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|370676
NZ_CP022310.1|WP_142232711.1|4557083_4558763_-|sodium/solute-symporter	unknown	unknown	gnl|CDD|271372
NZ_CP022310.1|WP_142232713.1|4562248_4562692_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379228
NZ_CP022310.1|WP_142194863.1|4549340_4551152_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|223562
NZ_CP022310.1|WP_142194869.1|4558939_4560001_+|galactose-1-phosphate-uridylyltransferase	unknown	unknown	gnl|CDD|238341
NZ_CP022310.1|WP_142232705.1|4546386_4547277_+|TatD-family-deoxyribonuclease	unknown	unknown	gnl|CDD|238635
NZ_CP022310.1|WP_142232702.1|4537971_4539033_-|cobalt-ABC-transporter-permease	unknown	unknown	gnl|CDD|376649
NZ_CP022310.1|WP_142232703.1|4539225_4539588_+|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl|CDD|377399
NZ_CP022310.1|WP_142194870.1|4559997_4560960_+|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl|CDD|187558
NZ_CP022310.1|WP_142232709.1|4555545_4556217_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_CP022310.1|WP_142232707.1|4551385_4553182_+|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|237605
NZ_CP022310.1|WP_142194853.1|4539598_4541275_-|penicillin-binding-protein	unknown	unknown	gnl|CDD|223839
NZ_CP022310.1|WP_142232704.1|4541407_4543039_-|penicillin-binding-protein	unknown	unknown	gnl|CDD|223839
NZ_CP022310.1|WP_142194859.1|4545381_4546239_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl|CDD|223390
NZ_CP022310.1|WP_142232712.1|4560988_4562158_+|galactokinase	unknown	unknown	gnl|CDD|223231
NZ_CP022310.1|WP_142194850.1|4537178_4537970_-|cobalt-ECF-transporter-T-component-CbiQ	unknown	unknown	gnl|CDD|274139
NZ_CP022310.1|WP_142195004.1|4536398_4537166_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213192

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142194861.1|4547311_4548181_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA	gnl|CDD|234708	PRK00274, ksgA, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase RsmA.	2.89002e-131
NZ_CP022310.1|WP_142194858.1|4543214_4544960_-|phospholipid-carrier-dependent-glycosyltransferase	gnl|CDD|224839	COG1928, PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones].	5.47347e-27
NZ_CP022310.1|WP_142232708.1|4553252_4555250_+|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	8.33625e-14
NZ_CP022310.1|WP_142232711.1|4557083_4558763_-|sodium/solute-symporter	gnl|CDD|271372	cd11478, SLC5sbd_u2, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP022310.1|WP_142232713.1|4562248_4562692_-|GNAT-family-N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	5.16151e-11
NZ_CP022310.1|WP_142194863.1|4549340_4551152_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	7.76996e-168
NZ_CP022310.1|WP_142194869.1|4558939_4560001_+|galactose-1-phosphate-uridylyltransferase	gnl|CDD|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	4.81372e-115
NZ_CP022310.1|WP_142232705.1|4546386_4547277_+|TatD-family-deoxyribonuclease	gnl|CDD|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	6.23021e-102
NZ_CP022310.1|WP_142232702.1|4537971_4539033_-|cobalt-ABC-transporter-permease	gnl|CDD|376649	pfam01891, CbiM, Cobalt uptake substrate-specific transmembrane region. This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein. The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway. The NikM protein is pfam10670.	2.55936e-52
NZ_CP022310.1|WP_142232703.1|4539225_4539588_+|SsgA-family-sporulation/cell-division-regulator	gnl|CDD|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	7.68756e-22
NZ_CP022310.1|WP_142194870.1|4559997_4560960_+|UDP-glucose-4-epimerase-GalE	gnl|CDD|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
NZ_CP022310.1|WP_142232709.1|4555545_4556217_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.33008e-33
NZ_CP022310.1|WP_142232707.1|4551385_4553182_+|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|237605	PRK14086, dnaA, chromosomal replication initiator protein DnaA.	6.13333e-13
NZ_CP022310.1|WP_142194853.1|4539598_4541275_-|penicillin-binding-protein	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	4.07494e-35
NZ_CP022310.1|WP_142232704.1|4541407_4543039_-|penicillin-binding-protein	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	1.62165e-40
NZ_CP022310.1|WP_142194859.1|4545381_4546239_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl|CDD|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	2.05011e-110
NZ_CP022310.1|WP_142232712.1|4560988_4562158_+|galactokinase	gnl|CDD|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	1.05961e-127
NZ_CP022310.1|WP_142194850.1|4537178_4537970_-|cobalt-ECF-transporter-T-component-CbiQ	gnl|CDD|274139	TIGR02454, Uncharacterized_protein_MJ1089, cobalt ECF transporter T component CbiQ. This model represents the CbiQ component of the cobalt-specific ECF-type. CbiQ is now recognized as the T component of energy-coupling factor (ECF)-type transporters. The S component confers specificity (CbiM-N for cobalt systems), which CbiO is the ABC-family ATPase. In general, proteins found by this model reside next to the other putative subunits of the complex, identified as CbiN, CbiO, or CbiM. Note that the designation of cobalt transporter has been spread excessively among ECF system transporters with many other specificities. [Transport and binding proteins, Cations and iron carrying compounds].	1.41466e-45
NZ_CP022310.1|WP_142195004.1|4536398_4537166_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	7.35654e-96

Protein sequences

>NZ_CP022310.1|WP_142194861.1|4547311_4548181_+|16S-rRNA-(adenine(1518)-N(6)/adenine(1519)-N(6))--dimethyltransferase-RsmA
MTSPTPDALLGPADVRELAAALGVRPTKQRGQNFVIDANTVRRIVRTAEVRPDDTVVEVGPGLGSLTLALLEVADRVTAVEIDDVLAAALPATIAARMPGRADRFALVHSDAMHVTELPGPAPTALVANLPYNVAVPVLLHMLESFPSIERTLVMVQSEVADRLAAAPGSKVYGVPSVKANWYAEVKRAGAIGRNVFWPAPNVDSGLVSLVRRTEPLKTTASRREVFAVVDAAFAQRRKTLRAALAGWAGSAAAAEAALVAAGVSPQARGESLTVEEFARIAEHKERTA
>NZ_CP022310.1|WP_142232705.1|4546386_4547277_+|TatD-family-deoxyribonuclease
MPSNAADKNAAPPLPEPLRVPVADSHTHLDMQSGTVEEALAKAASVGVTTVVQVGCDLAGSRWAAETAAAHDAVHATVALHPNEAPRIVHGDPDGWSRQGACEPGGDAGLDEALAEIDRLAALPQVRGVGETGLDYFRTGPEGKEAQEKSFRAHIEIAKRHGKTLVIHDRDAHADVLRVLKEEGAPERTVFHCYSGDAEMAEICASAGYYMSFAGNVTFKNAQNLRDALAVAPAELLLVETDAPFLTPAPYRGRPNAPYLVPVTVRAMAAVRGVDEDTLAAALGANTARAFGYPQA
>NZ_CP022310.1|WP_142194859.1|4545381_4546239_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MTGTLVLAGTPIGDVSDAPPRLAEELAGADVVAAEDTRRLRRLTQALGVTPRGRVVSYFEGNESARTPELVEELAGGARVLLVTDAGMPSVSDPGYRLVAAAVERDIKVTAVPGPSAVLTALALSGLPVDRFCFEGFLPRKAGERLGRLREVAEERRTLVYFEAPHRLDDTLAAMAEVFGAERRAAVCRELTKTYEEVRRGPLAELAAWAAEGVRGEITVVVEGAPDKGPEELDAAELVRRVRVREEAGERRKEAIAAVAVEAGLPKRQVFDAVVAAKSAGTGPV
>NZ_CP022310.1|WP_142194858.1|4543214_4544960_-|phospholipid-carrier-dependent-glycosyltransferase
MTSTASSMDLRKDQPPHEQQPAWHRRLRRFGHPGPDAGGDVRDRLVPPYTEPSGRLWATLGVPPGLAGRITRWSAWGGPLLVALLAGVLRFWNLGSPKAVIFDETYYAKDAWALVHRGFEVNWDKNANDLILSSGGNVPVPTDAAYVVHPPVGKYVIGLGELMFGFDPFGWRFMTALLGTLSVLLLCRIGRRLFRSTFLGCLAGALMAVDGLHFVMSRTSLLDGVLMFFVLAAFGCLLVDRDRAREKLAAALPVDADGRARPDAYAAETTRIGFRPWRLAAGVLLGLAIGTKWNGLYVTAAFCVMAVLWDVGSRRVAGARRPRLAVLQRDLGWAFLSTVPVAVVTYFASWTGWILSASDGTGGYYRDWATKDGRSSDWSWLFPDWWRSLWHYENQVYDFHVGLSSPHTYESNPWSWIVTGRPVSYFYESPAPGTDGCPADAGEKCAREVLAIGTPLLWWVACFALLYVLWRWFFRRDWRAGAIACGIAAGYAPWFLYQERTIFFFYAIVFLPFLCLAVAMLLGALVGPPRSSDTRRVAGATAAGVLTLLIAWNFIYFWPIYTGTPIPMDDWRARMWLDTWV
>NZ_CP022310.1|WP_142232704.1|4541407_4543039_-|penicillin-binding-protein
MGKGVKVAVVGGVFAVMVGGAGYGVYNIVSAVSGGGSGGAGAAETKRSGPPGADEVRATSEAFFAAWEKGDGAGAASYTDNAQEAGALLTGYGEDARIGAVRITPGKVTGTTVPFTVKATVRYDGTSKPLSYASELTVVRGRTTGRALVDWEPSVVHPDLKDGDTLVTGESAQPPIEAVDRDGVVLTKEKYPSLGPVLDTLREKYGEQAGGTPGVELVIKHADETADTPLLTLAEGKPGRLRTTIGAAVQDAAERAVRRFAESSVVAVKPSTGEVLAVANHREDGFNAAFQGQVAPGSTMKIVTAAMLIDNGVTSMNGPAPCPPTATWQSQTFKNLTGMQPDEGATLANSFLRSCNTAFIKLIDEQPLTDASLTQEAEQRFGLGRGDWKTGIASFDGSVPASGGPDRAANAIGQGQVQMNPLTMASVTATAITGAFRQPYLVPPELDGRQLRQADGLRADTAAQLKQMMRLTATQGTGRDAMTGLSDDIGAKTGSAEVDGKATSDSWFTGFRNDVAAAAMAQQGGHGGDAAGPIVAAVLRAGS
>NZ_CP022310.1|WP_142194853.1|4539598_4541275_-|penicillin-binding-protein
MGNRGHAGERRKTRPAVLGGVIAVVVGGAGFGAYALLGGGGAAAEDGTRTTSAQQEEDVRTGPLSAVEVTGTAERFLTAWQSGKVSEAAAVTDDPKAAAALLTAYAKDAGVKDVTLTAGARSGGKVPFSVKGTVSYEDVSKPLAYDSALTVVRRAGDGEPRVAWRPQVVHPDLKDGDKLVTGESGTPPVKALDRDGGELTTEKYPSLGSVLDGLREKYGEKAGGEAGVELRVVRGKESQKAKLSDKTLLELSEGTPGTVKTTLNPSLQAAAEEQVARKERASVVVVRPSTGEILAVANSSHGFNVAFQGSLAPGSTMKVITSSMLIEKGLASMDEKHPCPKYFSYGGWKFQNDDKFEIKDGTFKASFARSCNTAFISQAPELKNDDLTKQAQQVFGLSMNNWQVGVPTFDGSVPVQSAAPMAASLIGQGGVRMNPLNMASVSATVQSGVFRQPYLVSPEVDGRTLATASRTLSSGTLAQLRELMSYTAAYGTAAEAMAGVGGQTGAKTGSAEVDGQKKPNGWFTAYRGDLAAAGVVQAAGHGGSTAGPIVAALLKNGG
>NZ_CP022310.1|WP_142232703.1|4539225_4539588_+|SsgA-family-sporulation/cell-division-regulator
MSVVEQYARVHVLTDADPLLEDRGAVPVVLRYDPETDPRCVRVGLPGPVAREWTVERDLLEQGLRAPAGSGAIRVWPCGRVQAVVEFHTGHGVSVVEFEMKTLARFLRRTHAAAAEPVPH
>NZ_CP022310.1|WP_142232702.1|4537971_4539033_-|cobalt-ABC-transporter-permease
MHAPDGFINAPVSAAAGLVAAGAIAVSLRGARRELDEATAPLAGLVAAFIFAVQMLNFPVAAGTSGHLLGGALAAILVGPFTGVLCVSVVLLMQAVLFADGGLTALGVNITDMAIVTTVVAYALFRGLVTVLPRTRRSVTVASFVAALVSVPASALVFTLLYAVGGTADVSIGKVATAMVGVHVLIGIGEAVITALTVGAVIAVRPDLVHGARGLKQRLKLRVNGELVDAPQAAPEPAPAAARSSRTVWITGLAASLVLAGFVSFYASADPDGLEKVATDHGIDQKAEEHAIADSPLADYGVEDVDDARLSGGLAGVIGVGVTVVAGTGVFWAVRRRRTGDAADAVSPADTSV
>NZ_CP022310.1|WP_142194850.1|4537178_4537970_-|cobalt-ECF-transporter-T-component-CbiQ
MGADGGTSHAFSSGGAHRLYRHGHSPVHALPPHTKLAAVLAFVLVVVSTPREAMWAFAVYAGLLAGVAYAARVPAGFLLKRLLIEVPFVAFAVLLPFVAEGERVDVLGLSLSVNGLWGAWNVLAKGTLGVAASVLLAATTELRALLLGLQRLKLPPLLVQIASFMVRYGDVITDEMRRMRIARESRGFEARGVRHWGVLAKSAGALFIRSYERGERVHLAMLSRGYAGSMPVIDEVTASRAQWSYALALPCAALVVCLLGWTL
>NZ_CP022310.1|WP_142195004.1|4536398_4537166_-|ATP-binding-cassette-domain-containing-protein
MDGVTASLEVSGLAFAYPDGHQALFGVDFSLARGERVALLGPNGAGKTTLVLHLNGILTGGTGTVTVAGLPVGKRHMAEIRRRVGIVFQDPDDQLFMPTVREDVAFGPAAAGLKGAALEERVDRALARVGMAEFKDRPPHHLSFGQRRRVAVATVLAMEPEILVLDEPSSNLDPASRRELADILRSLDVTVLMVTHDLPYALELCPRSLVLSDGVIAADGPTADLLADEALMRAHRLELPYGFDPRSVSAAPGRP
>NZ_CP022310.1|WP_142194863.1|4549340_4551152_+|ATP-binding-cassette-domain-containing-protein
MAVNLVNVENVSKVYGTRALLDGISLGVSEGDRIGVVGRNGDGKTTLIRMLARLEEADTGRVTHSGGLRLGVLTQHDSLDPEATVRHEVIGDMADHEWAGNAKVRDVLTGLFGGLDLPGFPKGLDTVIGPLSGGERRRIALAKLLIEEQDLIVLDEPTNHLDVEGIAWLAEHLRNRRSALVCVTHDRWFLDQVCTRMWDVQRGSVYEYEGGYSDYVFARAERERIAATEEAKRQNLVRKELAWLRRGAPARTSKPRFRVEAANELIADVPPPRDSSELMKFASSRLGKTVFDLEDVTVQAGPKVLLKHITWQLGPGDRIGLVGVNGAGKTSLLRALADAARSEGEVQPAAGQVRVGRTVKLAYLSQEVAELDPEWRVLQAVQQVRERVDLGKGREMTAGQLCETFGFNKEKQWTPVGDLSGGERRRLQLLRLLMDEPNVLFLDEPTNDLDIETLTQLEDLLDGWPGSMIVISHDRFFVERTTDRVFALLGDGTLRMLPRGIDEYLERRKRMEEAAAAAAVPAAAAQSATPERSAADQRAAKKELQKIERQLDKISEKETKLHAAIAEHATDFAKVAELDAELRELAGRREELELTWLELAEDA
>NZ_CP022310.1|WP_142232707.1|4551385_4553182_+|PQQ-binding-like-beta-propeller-repeat-protein
MTQPPNQPPHGGFGAPQEPPPGGGFGAPQTPPPPQGTPQGPPAGPPQPGYGYPQQQPPQQPGPYASGSYTPGPYGQPQQPGPYGQPQQPGPYGQPGYGYPQQPHFPGAPGTPPGGSGSRNPFKGKPALVVGAAVAALLVIGGTVWAVSGDSDSGKDDKPVAQGSDDPAPNGSGAPVNPGDGSGDGGEDPEDLNKGRKAGESKVLWYKEAPDAPGSGADAPGMWITDKVAVKAAYKELSAYNVTDGKPAWEAIAFPQKICAVTQDKTSDDRIVVAHMSGSSDRAKCNQLQLVDLNTGEKGWTQEVADGALFDSVLSIEMSLAGNTLMVGRSQSGTAYDMRTGDKLFDSRKYGDACFPAAFAGGKRLIQVASCGAGGNNEHDEVRELDPATGKVKWTYAYEKGWRIERAYSVDPLVLYATKEEDGDKKVWNIAAFTAGGKVRSQVSVDENFAPGCGWAVLARDLQGCEGVAVDANTLYLPTEATTGANEIVAISLDNGKERWRQKSPVEESMVPMKVEGGKLIAYVEPSYDAGGQVVSLPVGGSSHKPVELMQNPQGVADIENSFFSRSIDWVDGRFYISTTRLTGNDESKEKLMLAYGK
>NZ_CP022310.1|WP_142232708.1|4553252_4555250_+|PQQ-binding-like-beta-propeller-repeat-protein
MTQPPPPPNQPPQQPGFGPPQDPSSQQQPPAQPPAQPPAQPSGAPSGPDLSKNPEPGYGYPQAPQTPQTPPPGPPGTPPPAAGPSAPQGPGYGYPQQPPAPAAGYGYPGQQPQQQPQQPQPSGPYGQPQQPGAQGQPGYGQPGYGQPGYGQSAYGQPGYGQPGYGYPQPPTMPMQPQPGQPGGGRKFSAQMGIVVAAVVAIALIVGGGVWYASSSGKDDDKQTTAETGGTGGDTKGGDAGGGSTGAKEKAPADTASKVLFQVPAPKVPKGSSTISTSGSWLTDTVYAKSGIAEIVGYDRAKGTKKWTIDLPGPVCEATAHVTDDNKTAVTHKPAMPTKDDPQRCTQVALIDLEAGKEVWSKTAKSGTMEISFNNVTISGGTVAAGSTSGGAAWEVASGKQLWAPKTSDACYDAGYGGGAKLVAVRKCGTYEQRQLHIQTIDPKSGKVVSEYKMDEGIEYAGIVSTEPLVVAADVGDTAGDGSGISDFFSIDNKTGKLRTRISAPGEEFAARCDIITRIEKCSGLAVGNDRLYIPTEEHEGTGEYSQTNEVVAFDLSTGKQTGQRADAGDGYQLTPLRMDGGNVLAYKRPPYDKGGQIVTIDGASFKQTTLMENPATEAVRSAETRMLPDYAEILYAQGGLYMSGVYASDFGSSGKEYLVIAFGTG
>NZ_CP022310.1|WP_142232709.1|4555545_4556217_+|response-regulator
MGVRLMVVDDHRLLAEALASALKLRGHRVLAAAAPAVGAADLVISRAPEVCLLGTAAPAEPGTFDPIVKIKRERPQVAVVVLGPVPSPRGIAAAFASGASGYVRHDERIEGVERAIMKARAGEAAVAPQLLQGAFGELLNPVAQPDDEGQRLLQMLTPREVEVLVRVAEGEDTRLIAAGMGIAASTARTHVQRVLMKLGVGSRLEAAALAARTGLLDRAGPVG
>NZ_CP022310.1|WP_142232710.1|4556750_4557062_-|hypothetical-protein
MSEHYSERDLQREITDLETKSATAARLFDIRRIIGGLFVVYGVIVTIAGFTASDADINKAEGVNINLWTGLGMLVLGLLFLLWLKLRPTAPPPPDAIPEERKE
>NZ_CP022310.1|WP_142232711.1|4557083_4558763_-|sodium/solute-symporter
MQTPTYLAAELRLPTNWLDYTILGIYFVVVLGIGFAARRSVKTSLDFFLSGRSLPAWVTGLAFIAANLGATEILGMAANSAQYGVYTTHWYWIGAIPAMVFLGLVMMPFYYGSKVRSVPEFLLLRFDKAAHLLSSILFAAAAILIAGVNLYALAIVVEALLGWPQWVAIVVAGFFVLAYITLGGLSSAIYNEVLQFFVILAALIPITVLGLKSVGGWDGLSDSLTASRGGDFMTSWGGTGIGSDNPLGANWLTIVLGLGFVLSFGYWTTNFAEVQRALSARNLSAAQRTPLIAAFPKIFIVFLVMIPGLVAAVLVPKIGTADSDLQYNDAIPYLMEQLLPNGVLGIAVTGLLAAFMAGMAANVSSFNTVFTTDIWAKYVVKHREDAYYVRFGRLITAIGVLASIGTAFLASSFSNIMSYLQTLFSFFNVPMFVVFIIGMFWKRASMKSGFWGLIAGTTAAMLNYFWIYKQGIVDIPSDQGANFVSAIAGFVAGAVVMVAVSLFTAPKPADELQGLVYGTRSPGMAEPPAEGDDAWYRKPALLGWGAVVLAAACYIPFSF
>NZ_CP022310.1|WP_142194869.1|4558939_4560001_+|galactose-1-phosphate-uridylyltransferase
MKKTSTRLADGRELIYYDLGDDTVRDAVDRRPLDATVTTSEIRRDPLLGDSVAIASHRQGRTYHPPADECPLCPSEGDRLSEIPDSSYDVVVFENRFPSLAGDSGRCEVVCFTSDHHASFARLSEQQARLVLDAWTDRTSELSHLPSVEQVFCFENRGAEIGVTLQHPHGQIYAYPFTTPRTALMLRQVAAHKEATGGENLFDAVLERELAGERIVLEGEHWVAFVPYAAHWPYEVHLYPRRRVPDLLALDEAARTEFPQVYLELLKRFDRIFGEGEPPTPYIAAWHQAPFGQLEEFEGVTRDDFALHLELFTIRRTSGKLKFLAGSESGMNVFINDVPPERAAERLREVASS
>NZ_CP022310.1|WP_142194870.1|4559997_4560960_+|UDP-glucose-4-epimerase-GalE
MSGKYLVTGGAGYVGSVVAQHLVEAGHEVVVLDNLSTGFREAVPADASFIEGDIRDAAKWLDPSFDGVLHFAAFSQVGESVVKPEKYWDNNVGGTMALLGAMREAGVRRLVFSSTAATYGEPEQVPIPESAPTRPTSPYGASKLAVDHMITGEAAAHGLGAVSLRYFNVAGAYGRYGERHDPESHLIPLVLQVAQGRRDAISVYGDDYPTPDGTCVRDYIHVADLADAHLLALRAAAPGEHLICNLGNGNGFSVREVVETVRRVTGHPIPEVVAPRRGGDPAVLVASADTAREKLGWNPSRADLTGIVADAWEFAQQRAK
>NZ_CP022310.1|WP_142232712.1|4560988_4562158_+|galactokinase
MSESSEVVAESVAERFQQLYGGAPDGVWAAPGRVNLIGEHTDYNDGFVMPFALPHTVVAAVSRRTDGVLRLHSADVDGPVVELAVDALAPESDKNWTAYPSGVVWALREAGHAVTGADIHLASTVPSGAGLSSSAALEVVVALAMNDLFGLGLRGWQLARLCQRAENVYVGAPVGIMDQTASACCEAGHALFLDTRDLSQRQIPFDLAAEGMRLLVVDTRVKHSHSEGEYGKRRAGCEKGAALLGVDALRDVPFADLDAALARLGDEEVRRLVRHVVTEDERVERVVSLLEAGDTRAIGPVLVEGHASLRDDFRISCPELDLVVDTALTAGALGARMTGGGFGGSAIVLAEEADVLAVTKAVEEAFAQAGFKAPRVFEAVPSAGARRMR
>NZ_CP022310.1|WP_142232713.1|4562248_4562692_-|GNAT-family-N-acetyltransferase
MFRLETEVDKARRDLLRRRLRDTNTAASPHLRALRGTPDERESPLHVWALDANGELAGGLVGHTWTTWLHVTYLWVDDRHRGAGLGSRLLAQAERVAAGERACTASRVETWDFQAPGFYRKHGYEVVCVIPDYPPGITEFTLTKRLG

Crispr_ID: NZ_CP022310_14

• CRISPR_ID: NZ_CP022310_14
• CRISPR_location: 4933335-4933442
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: DEDDh

Consensus repeat of NZ_CP022310_14

Consensus_repeat	Method
GACCGCGAGCATCCGGTTCGGTGACCGGCGGCTCCGG	CRISPRCasFinder

spacers of NZ_CP022310_14

>14.1|4933372|34|NZ_CP022310|CRISPRCasFinder
GTTCGGTGACCGGCGGCTCCGGCTCCGGTTCCGC

CRISPR arrays and Neighbor proteins around NZ_CP022310_14

CRISPR arrays

The CRISPR arrays of NZ_CP022310_14

>merge|NZ_CP022310|14|4933335-4933442|CRISPRCasFinder
GACCGCGAGCCCCAGGTTCCGCGACCGCGAGCATCCGGTTCGGTGACCGGCGGCTCCGGCTCCGGTTCCGCGACCGCGAGCTTCCGGTTCGGTGACCGCCGGCTCCGG

>NZ_CP022310|14|12|4933335-4933442|CRISPRCasFinder
GACCGCGAGCCCCAGGTTCCGCGACCGCGAGCATCCG	GTTCGGTGACCGGCGGCTCCGGCTCCGGTTCCGC
GACCGCGAGCTTCCGGTTCGGTGACCGCCGGCTCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142195199.1|4941159_4942389_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|181818
NZ_CP022310.1|WP_142195200.1|4944261_4944789_+|universal-stress-protein	unknown	unknown	gnl|CDD|366180
NZ_CP022310.1|WP_142195189.1|4927900_4928773_+|fused-MFS/spermidine-synthase	unknown	unknown	gnl|CDD|223498
NZ_CP022310.1|WP_142195193.1|4933750_4935193_-|beta-glucosidase	unknown	unknown	gnl|CDD|274539
NZ_CP022310.1|WP_142232863.1|4922744_4923911_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142195202.1|4946773_4947031_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142232865.1|4925730_4927182_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142195196.1|4937238_4938594_-|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270303
NZ_CP022310.1|WP_142232864.1|4925006_4925603_+|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|366010
NZ_CP022310.1|WP_142195194.1|4935304_4936210_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223472
NZ_CP022310.1|WP_142195201.1|4944929_4946747_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl|CDD|234729
NZ_CP022310.1|WP_142232868.1|4931775_4933230_+|sugar-hydrolase	unknown	unknown	gnl|CDD|119360
NZ_CP022310.1|WP_167530205.1|4929554_4930262_+|response-regulator	unknown	unknown	gnl|CDD|223816
NZ_CP022310.1|WP_142195188.1|4927468_4927849_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142195195.1|4936222_4937233_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|224096
NZ_CP022310.1|WP_142195197.1|4938937_4939996_+|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224525
NZ_CP022310.1|WP_142232866.1|4928873_4929428_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
NZ_CP022310.1|WP_142195191.1|4930258_4931668_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NZ_CP022310.1|WP_142195198.1|4940382_4940985_-|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl|CDD|235429
NZ_CP022310.1|WP_142195172.1|4923861_4924821_-|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|379588

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022310.1|WP_142195198.1|4940382_4940985_-|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	3.7e-13	44.6	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142195199.1|4941159_4942389_-|helix-turn-helix-domain-containing-protein	gnl|CDD|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	3.04251e-126
NZ_CP022310.1|WP_142195200.1|4944261_4944789_+|universal-stress-protein	gnl|CDD|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.55671e-22
NZ_CP022310.1|WP_142195189.1|4927900_4928773_+|fused-MFS/spermidine-synthase	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	5.08764e-14
NZ_CP022310.1|WP_142195193.1|4933750_4935193_-|beta-glucosidase	gnl|CDD|274539	TIGR03356, BGL, beta-galactosidase.	0
NZ_CP022310.1|WP_142195194.1|4935304_4936210_-|ABC-transporter-permease-subunit	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	2.71494e-76
NZ_CP022310.1|WP_142195196.1|4937238_4938594_-|extracellular-solute-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.52833e-27
NZ_CP022310.1|WP_142232864.1|4925006_4925603_+|histidine-phosphatase-family-protein	gnl|CDD|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	3.51663e-56
NZ_CP022310.1|WP_142195201.1|4944929_4946747_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl|CDD|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP022310.1|WP_142232868.1|4931775_4933230_+|sugar-hydrolase	gnl|CDD|119360	cd06543, GH18_PF-ChiA-like, PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in archaea but also in eukaryotes and prokaryotes. PF-ChiA exhibits hydrolytic activity toward both colloidal and crystalline (beta/alpha) chitins at high temperature.	9.81991e-133
NZ_CP022310.1|WP_167530205.1|4929554_4930262_+|response-regulator	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.75682e-68
NZ_CP022310.1|WP_142195195.1|4936222_4937233_-|ABC-transporter-permease-subunit	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	5.11733e-84
NZ_CP022310.1|WP_142195197.1|4938937_4939996_+|substrate-binding-domain-containing-protein	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.90815e-109
NZ_CP022310.1|WP_142232866.1|4928873_4929428_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.0018226
NZ_CP022310.1|WP_142195191.1|4930258_4931668_+|HAMP-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.58757e-30
NZ_CP022310.1|WP_142195198.1|4940382_4940985_-|oligoribonuclease	gnl|CDD|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	2.3833e-115
NZ_CP022310.1|WP_142195172.1|4923861_4924821_-|phosphatase-PAP2-family-protein	gnl|CDD|379588	pfam14378, PAP2_3, PAP2 superfamily.	2.04728e-64

Protein sequences

>NZ_CP022310.1|WP_142232868.1|4931775_4933230_+|sugar-hydrolase
MSTHRRRVRGRNKLIGGVVAAAVAGGGAFLFTGTAQAAGVAAAYTRTSAWSTGYAAQYVVTNNSGERDADWTLEFDLPEGTELASLWNAESGVSGRHVTVRPAAWDTDGLAAGESVTVGFVVKGTAAPTGCVVDGAACATDGGPAPEPSGRPTDAPTPTAAPTDRPTPTEEPTATAEPTPGTGTGTTDDARFAPYVDTSLSPAFDLLASAEATGVKHYNLAFVTDGGGCTPTWGGTGDLASNPVAGQIGALRAAGGDVRVSFGGAAGSELGTTCTSVDALAAAYEKVVNAFDLTEVDFDVEGGALPNAAANTRRAQAVAQLQKAHPDLDVSFTLPVMPEGLTQDGVNLLADAKDNGVRIDAVNIMAMDYGPAYSDDMGTYAEQAATATQAQIKGVLGLSDSEAWKTVAVTPMIGVNDVVTEIFTVDDATQLVDFARSKGLGELSMWSGTRDQQCPGGTKPSADATCSSILQEKFAFSKAFAAYN
>NZ_CP022310.1|WP_142195191.1|4930258_4931668_+|HAMP-domain-containing-protein
MRWALVKVSLAVTAMVVVAFAVPLGLVVRELAGDRAFSNAERVAAAVAPALSITTDRDQLERVVASVGSDASLAVHLPAGDGGEALDIGRRRATAEDIAAVRKLGRVSTSAVSGGSALLQPVALSTGEIAVVEVFVPESEVTNGVGTAWAVLAAVGVALILGSVAVADRLGVRMVRPARRLVEGAHELGEGKLGARVPEEGPTELRLAAVAFNSMADQVVQLLANERELAADLSHRLRTPLTVLRLNAASLGDGPAAEQTRAAVEQLEREVDTIIRTARDAKPQTAAAGPGAGCDAAEVVRERMAFWSALAEDEGRKWRVAGADRPVRIPVARADLAAALDALLGNVFRHTAEGTAFAVDVHNGDDAVIVLVSDAGPGIPDPEAAMARGRGSGSDGSTGLGLDIVRRLAESTGGDVRIGSSVLGGTEVRIWIQLDGRERAPRRHGHRGTVRRRGPARLTASFNRLRSLP
>NZ_CP022310.1|WP_167530205.1|4929554_4930262_+|response-regulator
MVEDDQFVRSALIRQLTDASHTVRSVGTALEALREVAHFRFDVVVLDLGLPDLDGSEALKMLRGITDVPVIVATARDDETEIVRLLNAGADDYLTKPFSVEHLSARMAAVLRRARAGGGGAAPSPVIRVGGLTVDPLRRQAELDGALLDLTRREFDLLAFLAGRPGVVVPRKELLAEVWQQSYGDDQTIDVHLSWLRRKLGETAARPRYLHTLRGVGVKLEPPAQHPGTAVEPPR
>NZ_CP022310.1|WP_142232866.1|4928873_4929428_-|hypothetical-protein
MRRGLVHVLAWLLATGAAVTLSWWGVSTVLTGTAYDPPRALPIAAAGADESAGEQSYPVSSSTRRPPGEGRSEDAAEPREPSPGPDETSREPAPQPSRTATPPPSPAPATTGRVKGYDTRGGRAVFDLGETSASLVSATPGAGWSMQVWKTETWIRVEFASGADRVSVFCTWHDGPPRVDVGTY
>NZ_CP022310.1|WP_142195189.1|4927900_4928773_+|fused-MFS/spermidine-synthase
MGRSRNSARGQGGGAEAVVEQVDGGLARLVPDRDRARAWTLLIDEAPQSHVDLDDPAHLSFEYQRRFGHVVDLAAPPGKPLNAVHLGGGACTLARYVAATRPRSTQQVVERDAKLVQLVRRELPWDARARIRVRSTDAREGLAKVPDGWAGLVVADVFSGARTPAHLTSTEFLDDVRRALAPGGIYAANLADGPPLAHLRGQIATAAARFAELALIADPAVLRGKRFGNAVLVASDAPLPIAELTRRAASDPHPGRVQHGRELVDFTGGATPVTDLAAVASPAPPASVFR
>NZ_CP022310.1|WP_142195188.1|4927468_4927849_+|hypothetical-protein
MTCWSNDSSQRPGTDCDVVTVPARQGLEAVDILRRGAGDAVGPVLHDGGGTLGFLVPPGTAAAWDVPGSTCTRTDGRGLRLAPEPPVEGANWLLPPGDADRATDPAVLREALGEAQRLIEAADSCS
>NZ_CP022310.1|WP_142232865.1|4925730_4927182_-|hypothetical-protein
MASSTVPSSPPDRPARPNLVFRRLRGSRSPAEFAAAVRRAAREIGERVSCDARYVHRVEAGEIRCPNYAYERVFLHMFPGRTLTDLGFAPRSAVRGRRARTAGDLLPGPRAENPAGHTNENSGTHEPYETHNRYDTYDTHDHEESDVLRRAFMTGGGATVAAASLSPHGLAPDAAAAQRAVRRPGASDAGALEEAVRRIRLLDDRHGADGLYRRAAAPLRAAYALLDAGATRQRTADRLYAGAGELAISVGWLAHDSGRFDDARSHYAEALATARVTGDPGLEAHAFCNTAFLARDAGRPREAVRAAQAAQRVARSLGSPRLMSLLALREAGGWAGLADRTGCEQALTRAQTYFERGASEADPEWMTFYGEAELEGLEAQCWSTLGDWPRAARHARRAAELQDPHFTRNIALYTAELADDLARGGRPDEAARAGMRVLDLLSDVQSSRVRTMLAGTSRVLLPHRHASGVSAFLDRHAALPRMV
>NZ_CP022310.1|WP_142232864.1|4925006_4925603_+|histidine-phosphatase-family-protein
MAPRILLARHGQTEWSLSGKHTGRTDVPLLEEGRRGAKLLGERLHRAPYDGLSGVEVRTSPLSRARETCELAGFGERAQTWDTLMEWHYGAYEGMTPAEIQAVRPGWLIWRDGVPEGETLAEVTARADEVVAWARSADRDVLVFAHGHILRSIGARWLGLPLDFAARIRLNPTSLSVLGWAYGEPAVETWNDQGHLTA
>NZ_CP022310.1|WP_142195172.1|4923861_4924821_-|phosphatase-PAP2-family-protein
MPHTETPGTGTAPAARLRWWSELPIILLVYACYSAGRLVVRGDVSDAVDHGLAILRIEKALHLNAEHPLNRLFTAEPWLGIPADFWYASLHYLVTPALLVWLFRSHAVRYRAARTWLMTSTFIGLIGFTLLPTCPPRLLDPSHGFVDTMAHYSAYGWWGGEASAPRGLGGMTNQYAAMPSLHVGWSLWCGVILWRYGRTPLARAAAVAYPLVTVIVVMGTANHYFLDAVAGAAVMGAGLLLAPYVMRCTDLAKARWLSRPAPVTAAASGAGSPIVSAGCQTSAGERFPRQRQPESRYGPAAEPGASPSDAGEGAPAPAR
>NZ_CP022310.1|WP_142232863.1|4922744_4923911_-|hypothetical-protein
MPPPRTREKALRHRLAELRGPEVPAKALDARALAALAANPGCRRRAILDGAGVNKAALASALGAPSVFGQSQFAFVRGNAFEAKVKADGGTELLRLAHEKLDRAAEPPAGAHVPDLTAQGPEGRTARTELALREATEAASAAPGAWTLLDHPMLALDVAGSPAFLEPDAVVVHPDGSWTVVEIKSFPMLDGAADPAKVGAAARQAAVYVLALERVAARLEPSPRVRHRILLVCPKDFSNLPTASAVDVRKQRAVTARQLDRLTRIEEIADTLPEGTCFSPELPAERLAAAVESVPATYAPECLSACELAFHCRDRSRAAGAVTRLGRPVRAELGALTTVEEVLAAARGEAGDPDDPTVAALRRAAALRAEALADAPVRVAAREVAPCR
>NZ_CP022310.1|WP_142195193.1|4933750_4935193_-|beta-glucosidase
MSDSATPANPVTFPPAFLWGAATSAYQIEGAVREDGRTPSIWDTFSHTPGKTAGGDTGDIAVDHYHRYREDVALMAELGLSAYRFSISWSRVQPTGRGPAVQRGLDFYRRLVDELLAHGIKPAVTLYHWDLPQELEDAGGWPERDTAYRFAEYAAIVGEALGDRVEQWITLNEPWCSAFLGYASGVHAPGRTEPAASLKAAHHLNLAHGLGAKALRSVMPARNSVALSLNSSVVRPLSPGDPADVAAARKIDDLSSGIFHGPILHGAYPETLLEATSSLTDWSYVLDGDLDLIHQPLDALGLNYYTPTLVSAADPATKGPRADGHGASDHSPWPAADDVAFHQSPGEQTEMGWSVDPTGLHELIMRYTREAPGLPLYITENGAAYDDKPDADGTVHDPERVAYLHGHLSAVRRAITDGADVRGYFLWSLLDNFEWAYGYEKRFGAVYVDYVTQQRTPKSSALWYARAARSGALPALDDRI
>NZ_CP022310.1|WP_142195194.1|4935304_4936210_-|ABC-transporter-permease-subunit
MTTTVTPPETPPAKAQKRSRLPKSARAGGTLHGGPIAYTILVLFTIGSLFPLVWTAIAASRDNQRLAQTPPPFWFGSNLFKNLEIAWKDANLGEAFLNTTIVAGISAVTIVTLSTIAGFAFAKLRFKGRNALMLIVIGTMMVPPQLSVIPLYMMVAKLDWTDQLQAVIFPSLVSAFGVFFMRQYLIQALPDEIIEAARVDGASSWRVVWHVVFPAARPAMAVLGMLMFVQTWNDFLWPFLVLTQTGNPTVQVAVAGLGRGYTPDQSLIMAGALLGTLPLLLVFAIFGKQIVGGIMQGAVKG
>NZ_CP022310.1|WP_142195195.1|4936222_4937233_-|ABC-transporter-permease-subunit
MATRHDTAALPSKGGAAPGRPPGGSAKDQDERRRARLSRRWQRDMRWSPYAFVAPFFLLFLAFGLFPLIYTGWASLHQVELTAPTDMNWVGLRNYTRIFDDDFFWNAAKNTLTIGIISTVPQLLMAMGIAHILNYKLRASTFYRVAMLAPYATSIAAASLVFVLLFGRDYGMINWALDFVGIDPVDWQGEKWPSQIAVSTIIIWRWTGYNALIYLAAMQAIPQDLYESAALDGASRWQQFLHVTLPSLRPTILFTAVVSTIGASQVFGEPLLFDANKGASGGAEHQFQTLGLYLYEQGWVNQHLGRASAIAWTMFLILIVIGIINYVISRRLRASS
>NZ_CP022310.1|WP_142195196.1|4937238_4938594_-|extracellular-solute-binding-protein
MRARTLPLSRQRSGGGTPIARKALAIAAVVSLGTGLLAGCADDGGDDESGSSSGEGKTTITLGLFGTMGFKEAGLYAEYEKLNPDIKIAENVVERNENYYPALVNHLTTNSGLMDVQAIEVANIAEVVGTQADKFTDMSKVEGVNKADWLDWKWQQATTKDGQTIGLGTDVGPMAICYRKDLFEKAGLPTDREEVGKLWAGDWNKFIETGRKYKKAAGKDTFFMDSPGGLLNAVLSSEKQKFYDASGEVIYKSNPAVKDAFDLTAGAAKDGLVQSQTQFQPAWDQTIANNKFATVACPPWMLGYLKGKSQPDAAGKWDVAVAPKSGNWGGSFLGVPKSGKNVEEAQKLVAWLTAPEQQAKLFKVQGSFPSSQAAYDSPEVTGAKNEMTGDAPIGEIFSEAAKQIPVQVIGPKDQIIQQGLTDNGVILVTKGKSAAEAWETATKTIDNNLDK
>NZ_CP022310.1|WP_142195197.1|4938937_4939996_+|substrate-binding-domain-containing-protein
MASHGARGRSGGRPTLEEVAARAGVGRGTVSRVINGSPRVSDATRAAVEAAVAELGYVPNTAARALAANRTDAIALVVPEPETRFFAEPYFSDMLRGVGAALSDTEMQLLLIFAGSDRERQRLAQYLAAHRVDGVLLVSVHADDPLPDMLAQLEIPAVISGPRSAAETLTSVDSDNYGGARQAVEHLLGRGRRTIAHITGRLDVYGAQRRIDGYRDALREAGHAVDELLVEPGDFSEDGGRRAMEALLARRPDLDAVFAASDVTAAGARHVLREAGRRIPDDVALVGYDDSAIARHLDPPLTSVRQPIEEMGRAMIDLLLAEVADRRPAVSRELEPPRRMVLATELVERASS
>NZ_CP022310.1|WP_142195198.1|4940382_4940985_-|oligoribonuclease
MNDRMVWIDCEMTGLSLSDDALIEVAALVTDSELNVLGDGVDIVIRPPEQALETMPEVVREMHTASGLLAELENGTTLRDAEERVLAYVREHVKEPGKAPLCGNSVGTDRGFLLRDMPALENFLHYRIVDVSSIKELARRWYPRAYFNSPEKNGNHRALADIRESIAELRYYREAVFVPQPGPDSDTAKKIAAKHVLPGQ
>NZ_CP022310.1|WP_142195199.1|4941159_4942389_-|helix-turn-helix-domain-containing-protein
MSHDSTAAPETAARKLSGRRRKEIVAVLLFSGGPIFESSIPLSVFGVDRQDAGVPRYRLLVCGGEEGPLRTTGGLELTAPHGLEAISRAGTVVVPAWRSITSPPPEEALEALRRAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVDPRELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGNEAAGALARRLVVPPRRSGGQERYLDRSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYRARRPQSDRSQDTEAAPSTPGTLPPGPPTGHAGHPVPASLHPDSPLPHQARRTPAASALGPSLTASGVPGQRSAP
>NZ_CP022310.1|WP_142195200.1|4944261_4944789_+|universal-stress-protein
MAGHEFFEPADRKRSVADPTAAEPLAAEEPRHACDPAFRHGVVVGFDGSTSSERALAYAIGMARRLGSGLIIVHVANRLPTTVWAGCEPPVFVDVPDHRTEVLGLELACADYLAEVPWILVERGGDICHELEEVGREYEADAIVVGSTHGLVGRIFGSVAGRLAKRAQRPVVVIP
>NZ_CP022310.1|WP_142195201.1|4944929_4946747_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGRREVAPLLLEGLQRLEYRGYDSAGIAVTSPKTSGLKMVKAKGRVRDLEAKVPARFKGTTGIAHTRWATHGAPSDVNAHPHLDAEGKVAVVHNGIIDNASDLRRKLEADGVVFLSETDTEVLTHLIARSRAEKLEDKVRETVRLIEGTYGIAVLHADFPDRIVVARNGSPVVLGIGEKEMFVASDIAALVAHTRQIVTLDDGEMATLKADDFRTYTTEGTRTTAEPTTVEWEAASYDMGGHDTYMHKEIHEQAEAVDRVLRGRIDDRFSTVHLGGLNLDAREARRIRRVKILGCGTSYHAGMIGAQMIEELARIPADAEPASEFRYRNAVVDPDTLYIAVSQSGETYDVLAAVQELKRKGARVLGVVNVVGSAIAREADGGVYVHAGPEVCVVSTKCFTNTCVAFALLALHLGRTRDLSVRDGKRIIEGLRRLPDQIAEIMEQEEEIRKLALEYAEARSMLFIGRVRGYPVAREASLKLKEVSYIHAEAYPASELKHGPLALIEPAMPTVAIVPDDDLLEKNRAAMEEIKARSGRIVAVAHQEQEKADHTVVVPKNEDELDPILMGIPLQLLAYHTALALGRDIDKPRNLAKSVTVE
>NZ_CP022310.1|WP_142195202.1|4946773_4947031_-|hypothetical-protein
MHDELVDHLTRSTPLSRGEALRVIQDVLAYFDETTEEYVRRRHRELQAQGLVNATIFERIAADLRYRAVAPPELSLRQLRRIVYG

Crispr_ID: NZ_CP022310_15

• CRISPR_ID: NZ_CP022310_15
• CRISPR_location: 5345000-5345088
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_15

Consensus_repeat	Method
CGTTCGCCCTCGGCCTGGGACGG	CRISPRCasFinder

spacers of NZ_CP022310_15

>15.1|5345023|43|NZ_CP022310|CRISPRCasFinder
GGTCGTGTGCGGTACGTCCGGGGTGGTCCACTCGTCGTCGTCC

CRISPR arrays and Neighbor proteins around NZ_CP022310_15

CRISPR arrays

The CRISPR arrays of NZ_CP022310_15

>merge|NZ_CP022310|15|5345000-5345088|CRISPRCasFinder
CGTTCGCCCTCGGCCTGGGACGGGGTCGTGTGCGGTACGTCCGGGGTGGTCCACTCGTCGTCGTCCCGGTCGCCCTCGGCCTGGGACGG

>NZ_CP022310|15|13|5345000-5345088|CRISPRCasFinder
CGTTCGCCCTCGGCCTGGGACGG	GGTCGTGTGCGGTACGTCCGGGGTGGTCCACTCGTCGTCGTCC
CGGTCGCCCTCGGCCTGGGACGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142233022.1|5348734_5350090_-|acetyl-CoA-carboxylase	unknown	unknown	gnl|CDD|223895
NZ_CP022310.1|WP_142195520.1|5347548_5348586_-|rod-shape-determining-protein	unknown	unknown	gnl|CDD|336482
NZ_CP022310.1|WP_142195509.1|5333730_5334993_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|235640
NZ_CP022310.1|WP_142233023.1|5350082_5351543_-|AMP-binding-protein	unknown	unknown	gnl|CDD|236096
NZ_CP022310.1|WP_142195524.1|5353245_5353953_+|FCD-domain-containing-protein	unknown	unknown	gnl|CDD|225097
NZ_CP022310.1|WP_142233017.1|5335259_5337188_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224055
NZ_CP022310.1|WP_142195516.1|5343526_5344768_-|transcriptional-regulator	unknown	unknown	gnl|CDD|225822
NZ_CP022310.1|WP_142195514.1|5341479_5341881_-|DUF779-domain-containing-protein	unknown	unknown	gnl|CDD|377532
NZ_CP022310.1|WP_142195518.1|5346102_5346459_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP022310.1|WP_142233015.1|5330336_5331602_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|170080
NZ_CP022310.1|WP_142195512.1|5339035_5340490_-|sugar-kinase	unknown	unknown	gnl|CDD|198375
NZ_CP022310.1|WP_142233018.1|5337187_5338921_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224055
NZ_CP022310.1|WP_142233020.1|5345158_5345857_-|ANTAR-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP022310.1|WP_142233021.1|5346455_5347418_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|379605
NZ_CP022310.1|WP_142233026.1|5355428_5356301_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233019.1|5341880_5343398_-|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143434
NZ_CP022310.1|WP_142195513.1|5340553_5340859_-|YtxH-domain-containing-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233016.1|5331708_5333637_+|DNA-primase	unknown	unknown	gnl|CDD|235551
NZ_CP022310.1|WP_142233024.1|5351725_5353069_-|hypothetical-protein	unknown	unknown	gnl|CDD|115789
NZ_CP022310.1|WP_142233025.1|5353967_5355059_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223704

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233022.1|5348734_5350090_-|acetyl-CoA-carboxylase	gnl|CDD|223895	COG0825, AccA, Acetyl-CoA carboxylase alpha subunit [Lipid metabolism].	2.91306e-46
NZ_CP022310.1|WP_142195520.1|5347548_5348586_-|rod-shape-determining-protein	gnl|CDD|336482	pfam06723, MreB_Mbl, MreB/Mbl protein. This family consists of bacterial MreB and Mbl proteins as well as two related archaeal sequences. MreB is known to be a rod shape-determining protein in bacteria and goes to make up the bacterial cytoskeleton. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated that constituents of the eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl.	1.28682e-143
NZ_CP022310.1|WP_142195509.1|5333730_5334993_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	8.26113e-162
NZ_CP022310.1|WP_142233023.1|5350082_5351543_-|AMP-binding-protein	gnl|CDD|236096	PRK07787, PRK07787, acyl-CoA synthetase; Validated.	0
NZ_CP022310.1|WP_142195524.1|5353245_5353953_+|FCD-domain-containing-protein	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	6.11363e-51
NZ_CP022310.1|WP_142233017.1|5335259_5337188_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP022310.1|WP_142195516.1|5343526_5344768_-|transcriptional-regulator	gnl|CDD|225822	COG3284, AcoR, Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription].	1.33515e-19
NZ_CP022310.1|WP_142195514.1|5341479_5341881_-|DUF779-domain-containing-protein	gnl|CDD|377532	pfam05610, DUF779, Protein of unknown function (DUF779). This family consists of several bacterial proteins of unknown function.	9.48402e-68
NZ_CP022310.1|WP_142195518.1|5346102_5346459_+|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.16796e-12
NZ_CP022310.1|WP_142233015.1|5330336_5331602_+|FAD-dependent-oxidoreductase	gnl|CDD|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	4.64735e-68
NZ_CP022310.1|WP_142195512.1|5339035_5340490_-|sugar-kinase	gnl|CDD|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	3.90191e-110
NZ_CP022310.1|WP_142233018.1|5337187_5338921_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.50914e-158
NZ_CP022310.1|WP_142233020.1|5345158_5345857_-|ANTAR-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.80192e-15
NZ_CP022310.1|WP_142233021.1|5346455_5347418_+|sensor-histidine-kinase	gnl|CDD|379605	pfam14417, MEDS, MEDS: MEthanogen/methylotroph, DcmR Sensory domain. MEDS is prototyped by DcmR and is likely to function with the PocR domain in certain organisms in sensing hydrocarbon derivatives. The MEDS domain occurs fused to Histidine Kinase and as stand-alone version. Sequence analysis shows that it is a catalytically inactive version of the P-loop NTPase domain of the RecA superfamily.	2.04395e-39
NZ_CP022310.1|WP_142233019.1|5341880_5343398_-|aldehyde-dehydrogenase-family-protein	gnl|CDD|143434	cd07116, ALDH_ACDHII-AcoD, Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like. Included in this CD is the NAD+-dependent, acetaldehyde dehydrogenase II (AcDHII, AcoD, EC=1.2.1.3) from Ralstonia (Alcaligenes) eutrophus H16 involved in the catabolism of acetoin and ethanol, and similar proteins, such as, the dimeric dihydrolipoamide dehydrogenase of the acetoin dehydrogenase enzyme system of Klebsiella pneumonia. Also included are sequences similar to the NAD+-dependent chloroacetaldehyde dehydrogenases (AldA and AldB) of Xanthobacter autotrophicus GJ10 which are involved in the degradation of 1,2-dichloroethane. These proteins apparently require RpoN factors for expression.	0
NZ_CP022310.1|WP_142233016.1|5331708_5333637_+|DNA-primase	gnl|CDD|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP022310.1|WP_142233024.1|5351725_5353069_-|hypothetical-protein	gnl|CDD|115789	pfam07158, MatC_N, Dicarboxylate carrier protein MatC N-terminus. This family represents the N-terminal region of the bacterial dicarboxylate carrier protein MatC. The MatC protein is an integral membrane protein that could function as a malonate carrier.	2.70992e-58
NZ_CP022310.1|WP_142233025.1|5353967_5355059_-|MerR-family-transcriptional-regulator	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	9.09743e-48

Protein sequences

>NZ_CP022310.1|WP_142195516.1|5343526_5344768_-|transcriptional-regulator
MAGSSDLRRRRATLEDAWSRWVPRMRAAGPRPSGVAALRDDVAESWVRSLSSVDPTQDSAPAADGDAVRHRWNASPLRRPVDGLAEELRSIAEDAGFVTAVTDESGTILWTCGGRTMRRRAERVNFAPGGRWDEPAMGTNALSLALRTGRPSSVFSAEHLVTALHGWVCYCAPVHGPDGRLLGVLDMSTTWDRSHPLAMSTVRSLAATIEARLRAEAPRRAPRAPAPVRLTCLGSEQAVREGGVPLVLRPRQLEILTLLALEPDGFPPERLRTALYGDRPVTASTFKAEISHLRRALDGGVTTRRYALTAPVSCDAADVLRALESGDADTALDLYRGPLLPRSVAPGIEAWRTFLEVAVREAVLASGRPEHALRLGERAPYDAEVHEHALRLLDAGDPRRAVAAGRLATALRD
>NZ_CP022310.1|WP_142233019.1|5341880_5343398_-|aldehyde-dehydrogenase-family-protein
MVYAQPGTDGSIVEFAARYDNFIGGEWVAPVEGRYFENPTPVTGKVFCEVARSSAADVELALDAAHAAAPRWGRTSTTQRANILNRIADRIEENLERIAVAETWENGKPVRETLAADIPLAVDHFRYFAGVVRAQEGSIAEIDADTVAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNCVVIKPAEQTPASLLYVVELIADLLPPGVLNVVNGFGVEAGKPLASNSRVAKVAFTGETTTGRLIMQYASENIVPVTLELGGKSPNIFLPDVMAADDDYLDKAVEGFVMFALNQGEVCTCPSRALIHSSIYDAFMARCIERTEAIVGGDPLDPATMIGAQASNDQFEKILSYIDIGKQEGAQLLTGGDRRTVPGLEGGYYIQPTVFRGDNEMRIFQEEIFGPVVSVTTYDSVDEALKIANDTLYGLGAGVWTRDGNTAYRMGREIKAGRVWTNCYHAYPAHAAFGGYKKSGIGRENHKMMLDHYQQTKNLLVSYSGQKLGFF
>NZ_CP022310.1|WP_142195514.1|5341479_5341881_-|DUF779-domain-containing-protein
MTARTRRVELTPAAEDLVRRLAGLHGPVMFHQSGGCCDGSAPMCYPRGEFRVGASDVLLGHVAGDTPFWMSADQYAYWSHTHLTVDVVPGRGSGFSLEAPEGVRFLIRSRLLTDTEWQRIEAEPPLPTGADIA
>NZ_CP022310.1|WP_142195513.1|5340553_5340859_-|YtxH-domain-containing-protein
MRYRLTFVAGVVLGYVLGTKAGRERYEQMKRSAQQFTQNPAVRNTAETAAHQGREFADKAYHAVSDKVGDRMPDSVAQRVRTLRERTAHGPAEDDWGTSNT
>NZ_CP022310.1|WP_142195512.1|5339035_5340490_-|sugar-kinase
MGIVAGLDSAPDFTRIVVCDTDTGAVLRQGYAQHPVQGTDGGGRPSDVDPQAWLLSLGEAAGGGLLEGVQAIGVSAQQNALVPLDAQGNTVRPAIVGGDRRAQVAAADLVDALGGREAWAQAVGCVPGAAQPVTKLRWLARTEPENAARTAVLLQAHDWLVWQLLGRPVRRTTDRGGASGTGYWAAATGAYRPDLVELALGHQVMLPEVIGPSDAAGTTPEGLLISAGTGETMAAAFGLGIGLGDAVVSLGASGSVMAVHPEALVDQHGMITSLADATGMHLPVVTTLNAVRTLRGTAELLGVPDLEGLSELAMKSTPGAHGLVLLPYLEGERTPNLPHTAGTLAGLRRESMKPEHLARAAFEGMLCGLADALDVLRGRGVEVRRVFLLGPTAELPAVQAAAPSLFGAQVVVPAPADYAAIGAARQAAWALGVSQGTLDPRTPPVWQGAVAQVLDPGEELAVGQAVRQQFVSVREQTHPGAFRV
>NZ_CP022310.1|WP_142233018.1|5337187_5338921_-|ATP-binding-cassette-domain-containing-protein
MLIRLLRAFLRPYQRPIALLVLLQFVQTCATLYLPTLNADIIDRGVVEGDTGYILSYGAVMIGVSLAQVVCNIGAVYYGSRTASALGRDVRAAVFDRVQSFSAREVGHFGAPSLITRTTNDVQQVQMLVLMTFTLMVSAPIMCVGGIVMALGLDVPLSGVLVAVVPVLGICVTLIVRGLRPLFRTMQERLDTVNRVLREQITGNRVIRAFVRDTYEQRRFRRSNTELTDVSLGAGNLLALMFPVVMTVVNLSSIAVVWFGAHRIDSGGMQIGDLTAFLAYLMQIVMSVMMATFMFMMVPRAEVCAERIQEVLDTSSSVVPPAAPVTELRRHGHLEIRGAGFRYPGAEEPVLRSVDLVARPGEVTAVIGSTGSGKSTLLGLVPRLFDATDGEVLVDGVPVADIEPALLARTVGLVPQRPYLFAGTVATNLRYGNPDATDEELWHALEVAQGKDFVERLEGGLDAPIAQGGTNVSGGQRQRLAIARTLVQRPEIYLFDDSFSALDYATDAALRAALARETAEATVVIVAQRVATIRDADRIVVLDEGRVVGTGRHHELMADNDTYREIVLSQLTEAEAA
>NZ_CP022310.1|WP_142233017.1|5335259_5337188_-|ATP-binding-cassette-domain-containing-protein
MAGPGGRMMAGGGPDQRSIDFKGSSKRLLAQFRPERLTLYGLLACVVLSVALSVIGPKILGQATDLVFAGIVGREMPQGASKEQVLDAMRERGDGDVADMLRGTDFTPGEGIDFTAVGNVLLFALAVFVVAGLLMAVATRLVNRVVNLTVFRMREDVQKKLSRLPLSYFDRRQRGEVLSRATNDIDNIGQTLQQSMGQLINSLLTIIGVLAMMFYVSWILALVALVTVPLSFVVATRVGKRSQPHFVQQWRTTGTLNAHIEEMYTGHTLVKVFGRQEESAAKFAEENEALYEAGFKAQFNSGIMQPLMFFVSNINYVLVAVVGGLRVASGSLSIGDVQAFIQYSRQFSMPLTQVASMANLVQSGVASAERVFELLDAEEQQADPEPAERPERLRGRVELERVSFRYDPDKPLIEDLSLTVEPGRTVAVVGPTGAGKTTLVNLLMRFYEVSGGRITLDGVDIARMSRDDLRAGIGMVLQDTWLFGGTIAENIAYGAAREVTREEIEQAARAAHADRFVRTLPDGYDTVIDDEGSGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKAMARLAHGRTSFVIAHRLSTIRDADTILVMENGAIVEQGAHEKLLAADGPYARLYKAQFAQAVAEVD
>NZ_CP022310.1|WP_142195509.1|5333730_5334993_+|sigma-70-family-RNA-polymerase-sigma-factor
MPESSERGRSVTDGSRTSAVPLIAYGTDCGEAADSAPEVPLPPSMAAIILEVAPVQTQTLTQPDAGVLPAVPAQSRAAHHPETPPEPAECPAEALEPADAPALSAEPVAAPVRPETGGPTSDLFRQYLREIGRIPLLTAAEEVELARRVEAGLFAEEKLRLTPDLDNRLAHDLDRLVVMGRMAKRRLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRMLQERGYEPTPAEVAAHLDLPPERVGEVLRLAQEPVSLHAPVGEEDDVALGDLIEDGDAASPVESAAFLLLREHLEAVLSTLGERERKVVQLRYGLVDGRPRTLEEIGRIFGVTRERIRQIESKTLNKLRDHAFADQLRGYLD
>NZ_CP022310.1|WP_142233016.1|5331708_5333637_+|DNA-primase
MAGRINDEDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPSKGLFHCFGCQEGGDTITFVMKIDHLSFSEAVERLAGQAGITLRYEEGGYNPTHQRGERIRLVEAHKIAAEWYAEQLATSAEAETGRVFLAERGFDQAAAVHFGVGYSPQGWDHLTRFLRGKGFSDKELILSGLAQEGRRGPIDRFRGRLMWPIRDIGGDVVGFGARKLYEADNGPKYLNTPDTAIYRKSQVLYGIDLAKKDIAKSSRAVVVEGYTDVMACHLAGVTTAIATCGTAFGGDHIKILRRLLMDNGSARVIFTFDGDAAGQKAALRAFEDDQKFAAETYIAIAPDGMDPCDLRLAKGDEAVADLVEPRTPLFEFALRQIVRRYDLDTPAGRAAALDEAAPIVARIKNSGAQHEVAVELAGMLGILDTQFVVKRVAQLARWARDRGGKGPAPDRQQRGGGPQQYAAAPAGTAPRGPALNLRNPVFATERELLKLALQRPELVSPAFDAYGVDEFTAPPYAAVRQAIQDAGGAEYGTTDPQEYLIQVREAAPDDTVRAMVTELAVEAIMLHRGVKEVDETYAGAQLVTVRRRAVERRIRDITSRLTRLGAHGDPSELAAVQNELWVLQQYDQALREHGAAAL
>NZ_CP022310.1|WP_142233015.1|5330336_5331602_+|FAD-dependent-oxidoreductase
MVDADQTFVIVGGGLAGAKAAETLRTEGFTGRVILICDERDRPYERPPLSKGYLLGKDERESVFVHEPAWYARHDVELHLGQTVAGIDRAAKTVRFGEDGTTVRYDKLLLATGAEPRRLDIPGTDLAGVHHLRRIAHAERLKGVLAALGRDNGHLVIAGAGWIGLEVAAAARQYGAEVTVVHRGQAPLHSVLGPELGQLFAELHRENGVRFHFGATLTEITGQDGMVLAARTDDGEEHPAHAVLAAIGAAPRTSLAEAAGLELADRADGGGVLVDERLRTSDPDIHAAGDVASFPHTLFGTRLRVEHWANALNGGPAAARAMLGRDEVYDRVPYFFTDQYDLGMEYSGWAPPGSYDQVVIRGDAGRREFVAFWVKDGRVLAGMNVNVWDVTDPIQRLIRSGAPVDTEALADPHVPLESLAA
>NZ_CP022310.1|WP_142233020.1|5345158_5345857_-|ANTAR-domain-containing-protein
MTSAASWPLPGRPTPLVIDGRTDADRALLVPRGELVRGCADALAERLARLPAGVARVDLDMSGVHFMDSAGLDFLEVLRDHARRRQVRVTATRWNGQPRRILELAGLDTADPLRPPEPGGGPVPDHGPEPASSAVALERQERLRLLQEEVEQLRQAIASRPVIDQARGILMATHGCSSDEAWHILREASQLSNTKLREVAAAVTAGAAAEGTPPPPEVRTALSRALARRAAR
>NZ_CP022310.1|WP_142195518.1|5346102_5346459_+|STAS-domain-containing-protein
MSDSRQRTPDGPEGPRPILTVRPLEGCGGVRAAGEVGLGTHMIWERVLEQAVRGGETVYYLELSEVTFVDVAGAGALVAAAERLGDGRRFVVRRPPPGLRRVLEMLWPDQPGVEVSTT
>NZ_CP022310.1|WP_142233021.1|5346455_5347418_+|sensor-histidine-kinase
MTTSAGPVTTAHDPFVHPALFYRDEQEYLDGTVSFVREGLAAGEPVAVAVPGERLRLIGDALGGDAAHVRLLDMREAGRNPGRIIPGVLRAFADSHPAGQRVRIIGEPIWAGRTETEYPACVQHEALINAAFRGRAVTILCPYDAVRLPGPVLDDAYATHPTVIPAGSRAVRDSAAYAPDAVVSRYNEPLPPVADAMTFPFVAESLTAARHAATDEGRRLGLTGVTLEDLALATAELTTNSVLHGGGSGVLRIWAEDGHVLCEVRDGGRLTDPLAGRRPAAGGRRGGRGLLLVNLIADLVRVHTGDDGTTIRCWFPRSRP
>NZ_CP022310.1|WP_142195520.1|5347548_5348586_-|rod-shape-determining-protein
MTASLEQLRRCHFAVDLGAARTRVYVKGAGLVVDQPSVAAVNTRTGALIAVGELAEKMTGRTPDYIRVVRPVSGGTVVDIEMAQRMLRQLLGDRIRRTLRRKPRLRAAACTPHDADPLAQRAAIETLVGLGARRVELVDTLIAAAVGCGLPVEQPEATMIMVCGAAATQVAVLSLGSIVTAERIPVGGEAVDNAIVQHLRHQHELMLPSQSVRPLQLALHGNGLTPEGPESTEIHGRDVATGLARSVRVDTEAVRQAIQTPLTAVLDGIGKVLRGCPPDLVADLADRGIMMVGGSALLPGLDQMLRQATGMPVHIAERPDVCAVQGLGEMLEGRIAPIVLNPLGA
>NZ_CP022310.1|WP_142233022.1|5348734_5350090_-|acetyl-CoA-carboxylase
MADRLSARAAIAVVTDDFTELPYPERTSAPDGPLGWPGYDAARARAAERTGERESVICGTAVVEGTRAVVVAFEFGFLGGSLGERTGDRLEAAYVHARAHRLPVVPLVATGGSRMQEGMLALTQLQRVARESALTRQAGLPQIAVVRDPTTGGGWATLGAGADVVLALPDAQVGFAGSRVRPADADPAAYTARAQVAAGAADALVRPEDLRETLGRWLRLLTRPATAPAPPPHALGAAGPPAAGWDAVRRARAPERPRAAAYLDAYFTDRVTLSGDRCGGTDPDGMLCGFGEHEGRTVAYAAQTGTATRPAGYRTAARLVRLADRLGIPVLTLVDTPGAANDAEAERQGVGAAIADLFGAVAAARTPVTTLVVGEGGSGGALALAAPGNTWVTPDSYFSVIAPELAAAILKRPPDAVRTTADQLRVRPQDLVALGVVRGVVGPAGAGAPPG
>NZ_CP022310.1|WP_142233023.1|5350082_5351543_-|AMP-binding-protein
MSSLFPALTAGPAAADRPALRFGERALTYGDLAAAAGAVAGDLAGARRVAVWAAPSLETAVAVTAALLAGVTVVPLNPRSGEKELGHILSDSAPGLVLTAPGTDLPAPLAGLPRIDVDPAVRAPGALPDDRDLDDAHPALIVYTSGTTGPPKGAVVPRRAIAATLDALADAWQWTGDDVLVHGLPLFHVHGLVLGTLGPLRRGGSVRHLGRFTTEGVARELNDGATMLFGVPTMYHRVAEALPGAPDLAKALAGARLLVSGSAALPVHDHERIAAATGRRVIERYGMTETLMNTSVRADGEARPGTVGVPLPGVELRLVEEDGSPVAAYDGETVGEIQVRGPNLFTEYLNRPDATAEAFTADGWFRTGDMAVRDPDGYVRIVGRKATDLIKSGGYKIGAGEIENALLEHPGVREAAVTGEPDADLGERIVAWVVPADPKSPPALEALADHVAGRLAPHKRPRVVHHLDALPRNDMGKIMKRALHRG
>NZ_CP022310.1|WP_142233024.1|5351725_5353069_-|hypothetical-protein
MSPELVSILVLAVVFVIATTRSVNMGALAFAAAFGVGTLVAGLDADGVFAGFPGDLFVVLVGVTYLFAIARANGTTDWLVHAAVRLVRGRVALIPWVMFALTGALTAIGAVSPAAVAIVAPIALSFAARYRISPLLMGAMVVHGAQAGGFSPISIYGSIVNGIVEREKLPGSEITLFLASLLANLLIAAVVFVACGGVRLWSQGAVDDSGSAGAGGGSVTSGAGSGGGTCTASAPTAVATRPDAPAAVPLTAPVVATLVSLVALVVAVLGFDLDAGLTAITLAVVLSTVWPDDSRTAVGQIAWPTVLLICGVLTYVGVLDEMGTITWAGEGVGGIGVPLLAAVLLCYIGAIVSAFASSVGIMGALIPLAVPFLAQGEIGAVGMVAALAVSATVVDVSPFSTNGALVLAAAPDVDRERFFRQLMAYGGIVVAAVPAVAWLVMVVPGWG
>NZ_CP022310.1|WP_142195524.1|5353245_5353953_+|FCD-domain-containing-protein
MTDALRPMPRQRLYEQVLDRLRQYVTEGGLRAGDRLPPERDLAQRLGVSRASVKQAIVVLEVQGLVEARHGGGTYLVRDSLDVEPVERLVERRRRLPDVLEAREALETKLAELAAERRTDEDLAALRSALAHMADEIEAGGHGVEGDRLFHAAVTAAAHSALLAEFMRSISEQIAESRTESLRQPGRPHRSLAQHQAILDAVAAGEPRRAAAAMRRHVRTVAKVRLLDWDPEAER
>NZ_CP022310.1|WP_142233025.1|5353967_5355059_-|MerR-family-transcriptional-regulator
MAGEMLTIGAFARACGLSPKALRLYDELDLLRPARVDPDTGYRYYTAGQLERARLVAWLRRLGMPLARIRRVCALGADAAAVEVRAYWARVEADTAVRRDLAAFLVDHLTDVSRRDTTMSTGTLELRYHAHSDRGRVRTANQDAAYAGRRLLAVADGFGPAGGPAAGAAVAALRRLETREVPAGGVLNLLEDAVRGAARAVRDVAAGAEEAGTTLTATLWTGSRLALVHIGDSRAYLLRGGELFRVTHDHTVVQSLVDEGRLTEEEAASHPQRTLLLKALTGAEATAAPDLRLHDVRAGDRWLLCSDGLPRAVPDADVRRLLVASAGPAEAVGALIGAADEAGGPDNVACAVAYVVDAADAAA
>NZ_CP022310.1|WP_142233026.1|5355428_5356301_+|hypothetical-protein
MPRIALVTCRPGPDVAEDRDLPGLVSALREAGAEASAEVWDDGDVDWGAFDLAVIRSTWDYSWRSAEFTAWAERCAAVTRLANPADVVRWNTDKRYLGDLAAAGVPVVDTRYLAPGDTVVLPETHEYVVKPTSGAGARFAARYTPAEHDTAVRHVRRMHDEGFTAMVQPYVRSIDTAGERAVQFFGGSLLHAGRKGAVLAPGTPYDQRKVAHPGLTAWTPTAAELDVAERALAAVPGAPELLYARVDLVDGEDGRPRVMELELVEPNLFLWLHPESVPRVVKHLLSAAAR

Crispr_ID: NZ_CP022310_16

• CRISPR_ID: NZ_CP022310_16
• CRISPR_location: 5742394-5742525
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: WYL

Consensus repeat of NZ_CP022310_16

Consensus_repeat	Method
CAAGGGGCGCGGGGAACTGCGCGAACGAGGGGT	CRISPRCasFinder

spacers of NZ_CP022310_16

>16.1|5742427|66|NZ_CP022310|CRISPRCasFinder
GCGGGGAACTGCGCGAACGAGGGGTGCGGGGAACTGCGCGAACGAACGGCGCGGGGAACTGCGACG

CRISPR arrays and Neighbor proteins around NZ_CP022310_16

CRISPR arrays

The CRISPR arrays of NZ_CP022310_16

>merge|NZ_CP022310|16|5742394-5742525|CRISPRCasFinder
CCAGGAGCACGGGGAACTGCGCGAACAAGGGGCGCGGGGAACTGCGCGAACGAGGGGTGCGGGGAACTGCGCGAACGAACGGCGCGGGGAACTGCGACGCAAGGGGCGCGGGGAACTGCGCGAACGGGGGTC

>NZ_CP022310|16|14|5742394-5742525|CRISPRCasFinder
CCAGGAGCACGGGGAACTGCGCGAACAAGGGGC	GCGGGGAACTGCGCGAACGAGGGGTGCGGGGAACTGCGCGAACGAACGGCGCGGGGAACTGCGACG
CAAGGGGCGCGGGGAACTGCGCGAACGGGGGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142233180.1|5745132_5746332_-|bifunctional-adenosylcobinamide-kinase/adenosylcobinamide-phosphate-guanylyltransferase	unknown	unknown	gnl|CDD|376754
NZ_CP022310.1|WP_142195828.1|5746739_5747408_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|182918
NZ_CP022310.1|WP_142233171.1|5730166_5732869_-|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl|CDD|236500
NZ_CP022310.1|WP_142233170.1|5729129_5730107_-|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl|CDD|225253
NZ_CP022310.1|WP_142195820.1|5737474_5739007_-|leucyl-aminopeptidase	unknown	unknown	gnl|CDD|234863
NZ_CP022310.1|WP_142233177.1|5741636_5742374_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142195831.1|5749264_5749546_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142195833.1|5750988_5751675_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_CP022310.1|WP_142195830.1|5748440_5749226_+|PspA/IM30-family-protein	unknown	unknown	gnl|CDD|224755
NZ_CP022310.1|WP_142233181.1|5749673_5750927_+|two-component-sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP022310.1|WP_167530117.1|5747491_5748136_-|DUF3043-domain-containing-protein	unknown	unknown	gnl|CDD|378611
NZ_CP022310.1|WP_142233178.1|5742606_5743719_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	unknown	unknown	gnl|CDD|234636
NZ_CP022310.1|WP_142233172.1|5734034_5735783_-|2-oxoglutarate-dehydrogenase,-E2-component,-dihydrolipoamide-succinyltransferase	unknown	unknown	gnl|CDD|200219
NZ_CP022310.1|WP_142233174.1|5739320_5740109_+|endo-alpha-1,4-polygalactosaminidase	unknown	unknown	gnl|CDD|377061
NZ_CP022310.1|WP_142233175.1|5740068_5740674_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233179.1|5744070_5745120_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|372616
NZ_CP022310.1|WP_142233176.1|5740757_5741576_-|adenosylcobinamide-GDP-ribazoletransferase	unknown	unknown	gnl|CDD|234697
NZ_CP022310.1|WP_142195827.1|5746448_5746661_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233173.1|5735845_5737234_-|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl|CDD|235798
NZ_CP022310.1|WP_142195817.1|5733180_5733804_-|FCD-domain-containing-protein	unknown	unknown	gnl|CDD|224715

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022310.1|WP_142233170.1|5729129_5730107_-|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	6.3e-52	171.7	4.8

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233180.1|5745132_5746332_-|bifunctional-adenosylcobinamide-kinase/adenosylcobinamide-phosphate-guanylyltransferase	gnl|CDD|376754	pfam02283, CobU, Cobinamide kinase / cobinamide phosphate guanyltransferase. This family is composed of a group of bifunctional cobalamin biosynthesis enzymes which display cobinamide kinase and cobinamide phosphate guanyltransferase activity. The crystal structure of the enzyme reveals the molecule to be a trimer with a propeller-like shape.	1.73522e-64
NZ_CP022310.1|WP_142195828.1|5746739_5747408_-|methyltransferase-domain-containing-protein	gnl|CDD|182918	PRK11036, PRK11036, tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM.	2.4497e-21
NZ_CP022310.1|WP_142233171.1|5730166_5732869_-|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl|CDD|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NZ_CP022310.1|WP_142233170.1|5729129_5730107_-|WYL-domain-containing-protein	gnl|CDD|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.06014e-41
NZ_CP022310.1|WP_142233181.1|5749673_5750927_+|two-component-sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.35313e-42
NZ_CP022310.1|WP_142195833.1|5750988_5751675_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.25627e-63
NZ_CP022310.1|WP_142195830.1|5748440_5749226_+|PspA/IM30-family-protein	gnl|CDD|224755	COG1842, PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms].	2.86018e-28
NZ_CP022310.1|WP_167530117.1|5747491_5748136_-|DUF3043-domain-containing-protein	gnl|CDD|378611	pfam11241, DUF3043, Protein of unknown function (DUF3043). Some members in this family of proteins with unknown function are annotated as membrane proteins. This cannot be confirmed.	6.16988e-68
NZ_CP022310.1|WP_142233178.1|5742606_5743719_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	gnl|CDD|234636	PRK00105, cobT, nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Reviewed.	4.49153e-135
NZ_CP022310.1|WP_142233172.1|5734034_5735783_-|2-oxoglutarate-dehydrogenase,-E2-component,-dihydrolipoamide-succinyltransferase	gnl|CDD|200219	TIGR02927, putative_dihydrolipoamide_acyltransferase, 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. This model represents an Actinobacterial clade of E2 enzyme, a component of the 2-oxoglutarate dehydrogenase complex involved in the TCA cycle. These proteins have multiple domains including the catalytic domain (pfam00198), one or two biotin domains (pfam00364) and an E3-component binding domain (pfam02817).	0
NZ_CP022310.1|WP_142233173.1|5735845_5737234_-|dihydrolipoyl-dehydrogenase	gnl|CDD|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	0
NZ_CP022310.1|WP_142195820.1|5737474_5739007_-|leucyl-aminopeptidase	gnl|CDD|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	0
NZ_CP022310.1|WP_142233179.1|5744070_5745120_+|methyltransferase-domain-containing-protein	gnl|CDD|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.9869e-21
NZ_CP022310.1|WP_142233176.1|5740757_5741576_-|adenosylcobinamide-GDP-ribazoletransferase	gnl|CDD|234697	PRK00235, cobS, cobalamin synthase; Reviewed.	1.88046e-40
NZ_CP022310.1|WP_142233174.1|5739320_5740109_+|endo-alpha-1,4-polygalactosaminidase	gnl|CDD|377061	pfam03537, Glyco_hydro_114, Glycoside-hydrolase family GH114. This family is recognized as a glycosyl-hydrolase family, number 114. It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases.	4.01765e-102
NZ_CP022310.1|WP_142195817.1|5733180_5733804_-|FCD-domain-containing-protein	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.92163e-33

Protein sequences

>NZ_CP022310.1|WP_142233177.1|5741636_5742374_+|hypothetical-protein
MGHWLERNIIEPGKLPLLLALAAFVLTFLTTRVITRLIRAGKGPFGNVTAGAVHIHHVVPGVVLTVAGGFGAVAGGRHGFGSALSAVLFGIGAGLVLDEFALILHLDDVYWTEAGRKSVEMVVLTAALVGLLLVGFAPFGVNDLSEDELQNRASVAANVAVNFLFSLIALSKGKARTAVFGVIVPVVALIGSLRLARPDSPWARRFYRRRPRARARATLRAYRHDRRWSGPRRAVQDWLGGKPNP
>NZ_CP022310.1|WP_142233176.1|5740757_5741576_-|adenosylcobinamide-GDP-ribazoletransferase
MPATTPPSPASPASPASPADGLRFAFGTLTALPVRVTRWDRPAARAGMLCAPAAGLAVGVAAAAVGLLLLLLGAGAPLAAVATVAVPAALTRGLHLDGLADTADGLGSAKPAEDALRIMKQSDIGPFGVLTLVLALLAQVAALAQAYGDSWARGALAAVVSALVARLALTLAARTGVPPARPEGLGAAVAGVVPVAGAVGAALAVTAAAAAGGACFGAFGAVRAGLAVLAALAVAELLLRHCVRRFGGVTGDVFGGLAETAATTALVVMSLG
>NZ_CP022310.1|WP_142233175.1|5740068_5740674_-|hypothetical-protein
MSAFRRAAAWCVDFALVVALASGLAVLTFQRISALVTDVPALAARGGFDLLTSRGDVLGASEEFGLSLWDKSVLYVEQAFALLVLAAFLYQWACLALAGRTVGKGLTGLKVTPRASGRAAVRAAVTTMADVAVFAVACVLLVEGRFVLSLLVWACAVVLFLFNALPVLGPARRSLADRVAGTAVTGVRLSMPGAMHRVRTS
>NZ_CP022310.1|WP_142233174.1|5739320_5740109_+|endo-alpha-1,4-polygalactosaminidase
MRRPFPTVLLLAALAAACTTAPGPDAPAAGDRWQPRPGIAWQWQLSGRLDTSVDVPVYDIDGFDHSRETVEALHRDGRKVICYLSTGAWEDFRPDADDFPKSVIGRGNGWEGERWLDIRRTDVLEPIMAERIEMCRDKGFDAVEPDNMDGYRNRTGFPLTADDQLRYNRLIAKLAHDRGLAVGLKNDLDQIPELVDDFDFAVNEQCAQYGECDELTPFVEADKAVFHAEYELPTDRFCADSRRLKLSSLLKKYELGAWRRAC
>NZ_CP022310.1|WP_142195820.1|5737474_5739007_-|leucyl-aminopeptidase
MTALTLSTAAVPGLRADAIVIGVAKGSASKPGAPVVAPGAEAVDEAYDGRLAGVLETLGASGGEGEVTKLPAPAGFKAPLVVAVGLGAQPEKDAGYDTDALRRAAGVAARALAGTKKAAFALPVADAADAGAVAEGVLLGAYTFDAYKDRGKDAKNGKAPLGEAALLGGKPRDKAFKAAVERATAVAEELNRARDLINTPPNDLNPEAFAAIAQAAAKEHGIKVQVLDEKALTKGGYGGILGVGAGSASGPRLVKLSYTSSKAKKHLALVGKGITYDSGGISLKPAGHNETMKCDMSGAAAVFAAVVAAARLGLDVNVTGWLALAENMPSGSATRPGDVLRMYSGKTVEVLNTDAEGRLVLADALWAASQEKPDAIVDVATLTGAMMLALGSRTFGIMANDDAFRTAVHEAAEEVGEPAWPMPLPEHLRKGMDSATADIANMGERMGGGLVAGLFLREFVGEGITWAHLDIAGPAFNEGGPFGYTPKGGTGTAVRTLVRLAERAAAGDLA
>NZ_CP022310.1|WP_142233173.1|5735845_5737234_-|dihydrolipoyl-dehydrogenase
MANDASTVFDLVILGGGSGGYAAALRGAQLGLDVALIEKDKVGGTCLHRGCIPTKALLHAGEIADQARESEQFGVKATFEGIDVPAVHKYKDEVISGLYKGLQGLIASRKVTYIEGEGRLSSPTSVDVNGQRIQGRHVLLATGSVPKSLPGLEIDGNRIISSDHALVLDRVPKSAIVLGGGVIGVEFASAWKSFGSDVTIIEGLKHLVPVEDENSSKLLERAFRKRGIKFNLGTFFQKAEYTQDGVKVTLADGKEFEAEVLLVAVGRGPVSQGLGYEEAGVAMDRGYVLVDEYMRTNVPTISAVGDLVPTLQLAHVGFAEGILVAERLAGLKTVPIDYDGVPRVTYCHPEVASVGITEAKAKEIYGADKVVALKYNLAGNGRSKILKTAGEIKLVQVKDGAVVGVHMVGDRMGEQVGEAQLIYNWEALPAEVAQLVHAHPTQNEALGEAHLALAGKPLHSHD
>NZ_CP022310.1|WP_142233172.1|5734034_5735783_-|2-oxoglutarate-dehydrogenase,-E2-component,-dihydrolipoamide-succinyltransferase
MAVSVTLPALGESVTEGTVTRWLKAEGERVEADEPLLEVSTDKVDTEIPAPASGVLSSIKVAEDETVEVGAELALIDDGSGAPAAAPAAEQAPAEQAAPPAPEPQPQAQPSTEQPAPAPAPTAEAATGGGSAQGTDVVLPALGESVTEGTVTRWLKSVGDTVEADEPLLEVSTDKVDTEIPAPASGTLLEIVVGEDETAEVGAKLAVIGEAGAAPAAAPAPAAPEAPAQPEPTPAPQAPAAPAPQPAAPAPAPAAPAPAAAPAAPAAAQPTDEGAYVTPLVRKLAAENGVDLSTVQGTGVGGRIRKQDVLAAAEAAKAAAAAPAPAAPAAPAAKKAPALEASPLRGQTVKMPRIRKVIGDNMVKALHEQAQLSSVVEVDVTRLMKLRARAKDAFAAREGVKLSPMPFFVKAAAQALKAHAPINARINEAEGTITYFDTENIGIAVDSEKGLMTPVIKNAGDLNIAGIAKATAELAGKVRASKITPDELSGATFTISNTGSRGALFDTIIVPPGQVAILGIGATVKRPAVIETEEGTVIGVRDMTYLTLSYDHRLVDGADAARYLTAVKAILEAGEFEVELGL
>NZ_CP022310.1|WP_142195817.1|5733180_5733804_-|FCD-domain-containing-protein
MTAPVVHSLREQIREHILEGIISGRWQPGERIVERRIATELEVSQTPVREALRELESLRLIESAPNKGVRVRNLTAADLEESYPVRAGLEAIAAELAAARLAEDCSALEPHVAALYEADRLSDGTGQVRHTVAFHRELVRAAGNSVLLHTWEGLGIEVFTALSIRWLGTVQQSYAEEHEELVAAFRRRDPRIAELVKAHVLGCAPRA
>NZ_CP022310.1|WP_142233171.1|5730166_5732869_-|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MTDPNAIQPSELDQLPDRDPEETAEWQASLDAVAKAAGPHRAAYLMRRTLERAEGAGIALPKLLETDYVNTIPTSAEPAVDGDEEMEQRITAWNRWNAAAMVTRGSKYGVGGHIATFASAAWLYETGFNHFFRGKESDGSGDQLYIQGHASPGIYARAFLDGRINEQHLDNFRREAGGNGLPSYPHPRRLPWLWEFPTVSMGLGPISAIYQARFNRYLTSRGIKDVSDSHVWAFLGDGEMDEPESTTALTLAAREQLDNLTFVINCNLQRLDGPVRANFKIVQELEAQFRGAGWNVVKTLWGTAWDELFQLDTTGALVRRLREVPDAQVQTYQTRDAAYIREDFFGKDPALVEMAKLLSDDKILECFHVSRGGHEARKVYAAYKAALAHKGAPTVILAQTVKGHTLGEGFASKNANHQMKKLTVDEFKAMRDRLGLPISDAQFVDDVVPYAHPGADSPEVRYLQERRAALGGPAPARRVHPVAPLPQPADKAFAAFDKGSGSQNVATTMAFVRLVKDLVRDKETGKRWVPIVPDEARTFGMESLFPSLGIYSPMGQTYEPVDRDQLMYYKEAKNGQIFNEGITEAGAMAEFIAASTSYATHGETMIPFYIYYSMFGWQRTGDQMWQLGDQLGRGFLVGATAGRTTLTGEGLQHADGHSPVIAATNPAALTYDPAFAYEIGVIVKEGLRRMFGEARPGEDQNVFYYLTVYNEPLPQPAKPSAPGVDEGIVKGLYRFNTAESAGLSPAANAPRIQLLGSGTAIHWALKAQRMLAEEWGVAADVWSATSWTELRRDAMEADEALLRGEDRVPFVRQALQGAEGPVLAVSDYMRQVPDQIAQWVEQDYTSLGADGFGLSDTREAARRHFGVDAESIVVASLAQLARRGEVQATAVKEAREKYGL
>NZ_CP022310.1|WP_142233170.1|5729129_5730107_-|WYL-domain-containing-protein
MRAARLIKMVLLLQSRPAMTAAELARELEVSERTVTRDAQALSEAGVPVYADRGRIGGYRLVGGYRTRLTGLARSEAEALFLSGVPGALREMGLEDAASAARLKVSAALLPSLRDASRTAAQRFHLDAPNWFREPVTPELLPAVADAVWDDRRITARYRRDDTEVERELEPYGLVLKAGVWYLCARVAGTEAFRVYRIDRFTAVEAGEERFERAADFDLPAFWEERAEQFARSLLRAEVVVRLTAQGVRRLPHTVDPASAREALAEAGGPDGDGWVTVTLPVESEEVAHTQLTALGADVEVLAPRSLRERFAAEAARLAELYRPR
>NZ_CP022310.1|WP_142233178.1|5742606_5743719_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase
MSSLNLDDFTDLIERPDGGVRRDAEARRERQIVPPGALGRLDDLGEWLAAAQSAVPVRPVERPRVVLFAGDHGIAELGVSSRAAGSAAGLVREVLEGGRPVAVLARRLGVPVRVVDMALDCDPGSLPEDVVRHRVRRGSGRIDVEDALTSEEAEAAFRAGMAVADEEADSGTDLVVLGDVSVGGTTAAGVLVAALCGTDASVVTGRGGLAIDDLAWMRKCAAIRDALRRARPVLGDQLQLLATVGGADLTAMTGFLLQAAVRKLPVVLDGVVTAACALVGQRVAFRAPDWWLAAHDSGEPAQAKALDRMALEPLLTHGVTVGEGTGGLLALPLVQAAAALAAELPERAEESEEPETSDGLAKAEEPAKPE
>NZ_CP022310.1|WP_142233179.1|5744070_5745120_+|methyltransferase-domain-containing-protein
MSAPTPDTASPVPHGSARVHEPRRQDCPWCGSARLRNRLRTGDLRRHRPGLFTVDTCRDCGHTFQNPRLTAEGLAFYRRAVRGAPRDPATERVLALHAARHRRRSAARAMLPFGEPESWLDVGTGLARFPHTAREFFPYTAFDGTDLTARVERARALGRVEEAHIGPLTDPAVLARVAGRYDVVSLLHHLEHTTDPRAELHAALDALRPGGHLLVETLDPRCAYAVLFGRWWLPYDQPRRLHLLPPRNVRAELEGRGCTVVTAGHRAAHVPHDLAGLVALALSHTLPAPDTPWRAIPPSPLQRHLRTVLLRAGTPLVVAAAVTDLALAPLVRHTPFANAYRIIARKPAD
>NZ_CP022310.1|WP_142233180.1|5745132_5746332_-|bifunctional-adenosylcobinamide-kinase/adenosylcobinamide-phosphate-guanylyltransferase
MELTLLGTGAPAGLPRPDCPCAVCASALGPDARAATSLLVDGALLLDLTPGAAFAAARAGRSLGGVRQVLLSHPHDGPAVEVPAGLPQPGRVPDGRELALLTGHRVRAVALDAPGTGYAVTGTDGQRLLYLPPGGAPAGLEATSEPYAMVLLDVVGRPDALARLRETGAVGPTTDVVAVHLDHDVPPGTELARRLAAAGARAVPDGSTLDVGAYEDVPDVPRRTLVLGGARSGKSVEAERRLESFPEVVYVATGGSRNGDTEWAARVSAHQERRPGSWRTLETCDLVPLLKDDGPPLLVDCLSLWLTDAMDAVGAWDDAEWADGGERALRERVRELTESVRATRRTVVAVSNEVGSGIVPATASGRRYRDELGRLNAAFARECEQVLLVVAGQALVLRG
>NZ_CP022310.1|WP_142195827.1|5746448_5746661_+|hypothetical-protein
MAAWTWRFEKADGTQVEPAVPPEEFPTQGDAESWIGENWKALLEGGADQVRLLEDSTEIYGPMSLHAEQE
>NZ_CP022310.1|WP_142195828.1|5746739_5747408_-|methyltransferase-domain-containing-protein
MARQLEEQIVGRFPVGRRLRVLDVGMGRGAQALRLARAGHQVTGVEQDPVMIAAVREELAGEPEGIRERMRIVEGDGRDTGVHFRPGSFDVVLCHGVLLQVEEPDALLAGLGRMLAPGGLLSLLVRNGDAPAMRAGLSGDWAGALEAFSTVSYGLKRLTSTLAGIGAPLHTWYGVRVFTDTAADDADLPGDLEALLAAEERAGRTDPYRGVAALLHLCGVRG
>NZ_CP022310.1|WP_167530117.1|5747491_5748136_-|DUF3043-domain-containing-protein
MRLGSNPGHPVPLGFVFRSRAKEEKASAADKATVTDSKQTRHPEAPKGRPTPKRSVAQSQRRSVANTTMTRKEAAKRQREERRAALERQRQALASGDERYLPARDKGRVRRFARDFVDARFNIAEYFLPMAVIILVLSMIQVPQLQNAALLLWLVVIVMIVLDSVVTGFRLKKRLAERFPDDNRRGAVAYALMRSLQMRRLRLPKPQVKRGERP
>NZ_CP022310.1|WP_142195830.1|5748440_5749226_+|PspA/IM30-family-protein
MKRMGMIFRAKANKALDRAEDPRETLDYSYQKQLELLQKVRRGVADVATSRKRLELQLNQLQSQSSKLEDQGRKALALGREDLAREALSRRAALQQQVTDLETQHATLQGEEEKLTLAAQRLQAKVDAFRTKKETIKATYTAAQAQTRIGEAFSGISEEMGDVGLAIQRAEDKTAQLQARAGAIDELLASGALDDQSGMHKDDIQAELDRLSGGTDVELELQRMKAELAGGSSAGQQAIEGGSGQQQSQQQPQDTPRFDKQ
>NZ_CP022310.1|WP_142195831.1|5749264_5749546_+|hypothetical-protein
MIVRIMGEGQVRLAESRLADLNTLDEELLAEVEKGDGPGFRATLQALLAKVRELGEPLPDDALEPSDLILPSSDATLDEVKELLSDDGLIPGT
>NZ_CP022310.1|WP_142233181.1|5749673_5750927_+|two-component-sensor-histidine-kinase
MSTLTRARCRLQAHPFAADAALAAAVLACMVAGSFVDPHGPDGVDWGLRSPDPLSLVLMTLGALALVFRRRAPRTVLALAGGVSVAESVTGDPRAPVAMCAVVALYTVASTTDRPTTWRIGLLTTTVLTGTAMAAGPLPWYAQENLAIFAWTGIGATAGDAVRSRRAFVQAIRERAERAERTREEEARRRVAEERLRIARDLHDVVAHHIALVNVQAGVAAHVMDKRPDQAKEALAHVREASRSALGELRATVGLLRQSGEPEAPTEPAPGLDRLDELAGTFRSAGLRVEVARADQGTDLPAAVDLAAYRVIQEALTNVQKHAGTDARAEVSVVRVGPHIEVTVLDDGSGENPQDDPDDPDAPEDAPGGGHGLLGMRERVTALRGTLTTGPRYGGGFRVHAILPVEPRTSAARDSGR
>NZ_CP022310.1|WP_142195833.1|5750988_5751675_+|response-regulator
MTIRVLLADDQALLRSAFRVLVDSEPDMEVVGEASDGAEAVRLAREQRADVVLMDIRMPGTDGLAATRMISADPGLAGVRVVILTTFEVDDYVVQSLRAGASGFLGKGSEPEEMLNAIRIAADGEALLSPVATKGLIARFLAQEGTAGDAERDPARAERLDSLTVREREVLVQVAGGHSNDEIAERLQVSPLTVKTHVNRAMAKLGARDRAQLVVIAYESGLVRPRVE

Crispr_ID: NZ_CP022310_17

• CRISPR_ID: NZ_CP022310_17
• CRISPR_location: 5824942-5825030
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_17

Consensus_repeat	Method
GCCGGGCGGTGGCCGTTGCGTGGGGCGG	CRISPRCasFinder

spacers of NZ_CP022310_17

>17.1|5824970|33|NZ_CP022310|CRISPRCasFinder
TGGCCGTTGCGTGGGGCGGGCGGTGAGCACAGC

CRISPR arrays and Neighbor proteins around NZ_CP022310_17

CRISPR arrays

The CRISPR arrays of NZ_CP022310_17

>merge|NZ_CP022310|17|5824942-5825030|CRISPRCasFinder
GCCAGACGGTGACCACGGCGCCGGGCGGTGGCCGTTGCGTGGGGCGGGCGGTGAGCACAGCGCCGAGCTGTGGCCGCAGCGCCGAGCGG

>NZ_CP022310|17|15|5824942-5825030|CRISPRCasFinder
GCCAGACGGTGACCACGGCGCCGGGCGG	TGGCCGTTGCGTGGGGCGGGCGGTGAGCACAGC
GCCGAGCTGTGGCCGCAGCGCCGAGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142233213.1|5837272_5838793_+|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	unknown	unknown	gnl|CDD|234660
NZ_CP022310.1|WP_142195900.1|5824367_5824940_+|hypothetical-protein	unknown	unknown	gnl|CDD|376149
NZ_CP022310.1|WP_142195904.1|5832572_5833118_-|carbonic-anhydrase	unknown	unknown	gnl|CDD|239474
NZ_CP022310.1|WP_142233206.1|5815680_5816343_+|thiamine-phosphate-synthase	unknown	unknown	gnl|CDD|234590
NZ_CP022310.1|WP_142233210.1|5823307_5824201_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_CP022310.1|WP_142233207.1|5818488_5819985_-|NAD(P)-binding-protein	unknown	unknown	gnl|CDD|224154
NZ_CP022310.1|WP_142233211.1|5829865_5831227_-|DUF58-domain-containing-protein	unknown	unknown	gnl|CDD|224635
NZ_CP022310.1|WP_142233208.1|5820583_5821216_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP022310.1|WP_142195906.1|5834592_5835138_+|hypothetical-protein	unknown	unknown	gnl|CDD|368217
NZ_CP022310.1|WP_142233209.1|5821251_5823336_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|274414
NZ_CP022310.1|WP_125507055.1|5815044_5815410_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|375793
NZ_CP022310.1|WP_142234235.1|5813757_5814954_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|369639
NZ_CP022310.1|WP_142233212.1|5833536_5834493_+|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	unknown	unknown	gnl|CDD|234597
NZ_CP022310.1|WP_142195901.1|5826543_5826948_+|DUF3040-domain-containing-protein	unknown	unknown	gnl|CDD|378610
NZ_CP022310.1|WP_142195894.1|5816450_5817374_+|methylenetetrahydrofolate-reductase-[NAD(P)H]	unknown	unknown	gnl|CDD|366988
NZ_CP022310.1|WP_142234236.1|5827478_5829866_-|DUF4129-domain-containing-protein	unknown	unknown	gnl|CDD|376628
NZ_CP022310.1|WP_142195895.1|5817430_5818375_+|hypothetical-protein	unknown	unknown	gnl|CDD|236669
NZ_CP022310.1|WP_142195903.1|5831226_5832240_-|AAA-domain-containing-protein	unknown	unknown	gnl|CDD|223786
NZ_CP022310.1|WP_142195907.1|5835134_5837102_+|penicillin-binding-protein-2	unknown	unknown	gnl|CDD|223839
NZ_CP022310.1|WP_161175631.1|5825482_5826253_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|182918

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233213.1|5837272_5838793_+|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase	gnl|CDD|234660	PRK00139, murE, UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional.	0
NZ_CP022310.1|WP_142195900.1|5824367_5824940_+|hypothetical-protein	gnl|CDD|376149	pfam18726, HEPN_SAV_6107, SAV_6107-like HEPN. SAV_6107-like HEPN.	1.35319e-30
NZ_CP022310.1|WP_142195904.1|5832572_5833118_-|carbonic-anhydrase	gnl|CDD|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	2.354e-58
NZ_CP022310.1|WP_142233206.1|5815680_5816343_+|thiamine-phosphate-synthase	gnl|CDD|234590	PRK00043, thiE, thiamine phosphate synthase.	4.36889e-85
NZ_CP022310.1|WP_142233210.1|5823307_5824201_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.54433e-24
NZ_CP022310.1|WP_142233207.1|5818488_5819985_-|NAD(P)-binding-protein	gnl|CDD|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	1.9233e-61
NZ_CP022310.1|WP_142233211.1|5829865_5831227_-|DUF58-domain-containing-protein	gnl|CDD|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	4.05759e-27
NZ_CP022310.1|WP_142233208.1|5820583_5821216_-|TetR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.82988e-17
NZ_CP022310.1|WP_142195906.1|5834592_5835138_+|hypothetical-protein	gnl|CDD|368217	pfam04977, DivIC, Septum formation initiator. DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.	6.0633e-05
NZ_CP022310.1|WP_142233209.1|5821251_5823336_-|ABC-transporter-permease	gnl|CDD|274414	TIGR03062, hypothetical_protein_lp_1332, YhgE/Pip C-terminal domain. This family contains the C-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03061, represents the conserved N-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.	7.52094e-90
NZ_CP022310.1|WP_125507055.1|5815044_5815410_+|helix-turn-helix-domain-containing-protein	gnl|CDD|375793	pfam18367, Rv2175c_C, Rv2175c C-terminal domain of unknown function. This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.	1.07836e-28
NZ_CP022310.1|WP_142234235.1|5813757_5814954_+|FAD-dependent-oxidoreductase	gnl|CDD|369639	pfam07992, Pyr_redox_2, Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.	1.93612e-57
NZ_CP022310.1|WP_142233212.1|5833536_5834493_+|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH	gnl|CDD|234597	PRK00050, PRK00050, 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH.	1.29705e-157
NZ_CP022310.1|WP_142195901.1|5826543_5826948_+|DUF3040-domain-containing-protein	gnl|CDD|378610	pfam11239, DUF3040, Protein of unknown function (DUF3040). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	1.39296e-30
NZ_CP022310.1|WP_142195894.1|5816450_5817374_+|methylenetetrahydrofolate-reductase-[NAD(P)H]	gnl|CDD|366988	pfam02219, MTHFR, Methylenetetrahydrofolate reductase. This family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from bacteria and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The structure for this domain is known to be a TIM barrel.	2.45439e-145
NZ_CP022310.1|WP_142234236.1|5827478_5829866_-|DUF4129-domain-containing-protein	gnl|CDD|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	9.04892e-23
NZ_CP022310.1|WP_142195895.1|5817430_5818375_+|hypothetical-protein	gnl|CDD|236669	PRK10263, PRK10263, DNA translocase FtsK; Provisional.	0.000264694
NZ_CP022310.1|WP_142195903.1|5831226_5832240_-|AAA-domain-containing-protein	gnl|CDD|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	3.99607e-97
NZ_CP022310.1|WP_142195907.1|5835134_5837102_+|penicillin-binding-protein-2	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	2.38068e-141
NZ_CP022310.1|WP_161175631.1|5825482_5826253_+|methyltransferase-domain-containing-protein	gnl|CDD|182918	PRK11036, PRK11036, tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM.	1.74965e-25

Protein sequences

>NZ_CP022310.1|WP_142195900.1|5824367_5824940_+|hypothetical-protein
MANSSASAARRHRATRPAPSLNGPASDIHPVLRRAAAPPAALDLLAQARSGLDEAAVLDTPNERYATAHLAALRTAAAVLAARGRPETSPRARARIRSAWDVLPEIAPELTEWSALFAAGAARRARAEAGIQGAATVRDADDLIRDAAMFLRLVERMLVLQPALPQPRTDTDHPRPGRPDDAPRDMPDAG
>NZ_CP022310.1|WP_142233210.1|5823307_5824201_-|ATP-binding-cassette-domain-containing-protein
MDGPHGLAVTASGFGLKGPRGWAFRGVSADAEPGSLIAVEGPSGSGRTCLLLALTGRMRPTEGRAAVGGLELPRRMAAVRRVSALAHVAGVTELDPALTVGEHLREQALLQRRFGDAPRRLLPRPRAVRAREERERVDTALAAAGLDPESLPKGERTAVRDLERVEALRLSLALALLGRPRLLGVDDVDLKLPPAERVVVWDLLRSVAAAGTTVLAVCSEAPRDAVTVRTGAGPHDEDQQHDGEHGQDRHDDDKHNHDKHHHGEHDGHDEHDDDKHEEHEEHEEKEDADALAATGRS
>NZ_CP022310.1|WP_142233209.1|5821251_5823336_-|ABC-transporter-permease
MRSPRLAALELRRFGRGPLPRAALVALLVLPLLYGALYLWSFWDPYGRLDRIPVALVNEDRGAPADGKRITAGDDIAEGLRDSGTFDWHEVSAAEARRGVEDGTYYLSLTMPADFSRRIASSSGDSPETGALQVRTNDANNYIVGQISRTVFGEVRRAASTKTSRSFLDRIFVSFSGIHDETVKAAEGADELNGGIGKAEKGAKDLAAGLDDARKGSGKLSKGLKDLHDGAGDLADGSKKVADGTRRLAEKVNAVNAEVGPFLKANEKTIGDTARFVADSAGGLRDDLDALEEKAPAAAKDARAASAGMAEVHRTRCADAVLPDPACPDLEKARDATAAAAAVADDVNTLVTDHRTDLKQLDTHLGTLEKQARALADRAPHLSDDLDDAVTRINRLNSGAGKVAAGAKKLNKGLGTAETGAADLDKGVGRLKTGADDLNGGLYKLVDGSGELAGGLHDGAGRIPDYDERDRDRRTEVMADPVQLVSRDLHKAPDYGTGFAPYFIPLSLWVGAMVAYMLIAPMNGRALAAGASAWRIALAGWLPVAAIGVAQTVALMSVLHWGLGLQMARAAGTVGFLFLVTACFAAIVQWLNARFGAAGRILVLALLMLQLTSAGGTYPVQTSPGFFNAVHPFLPMSHVVEALRRLISGGGLQPVWLACAVLAAFTAGALALTALSARRRQVWTVDRLHPELSL
>NZ_CP022310.1|WP_142233208.1|5820583_5821216_-|TetR-family-transcriptional-regulator
MDSSSTTSGGGSARREATRQKLYEAAVTLIAEQGFSATTVDEIAERAGVAKGTVYYNFASKSVLFEELLRHGVGLLTASLREAAERTAGDGGSKVDALDAMIRAGLVFIDRYPAFTQLYVAELWRTNRAWQSTLMVVRQQAVAVVEGVLRDGVANGEFSEEIDVPLTAAALVGMVLVAALDWKSFQPERSLDDVHAALSRLLQGRVSGCR
>NZ_CP022310.1|WP_142233207.1|5818488_5819985_-|NAD(P)-binding-protein
MARIAVIGAGMGAMAAAARLAVAGHRVVVYERTETYGGALRRLERDGFRFDTGPGLLPLPAVYRDLFLKTGREPLEECVDLVQVDPSTHHVFADGTRVSLPNASRAGVVAALEDAFGPAAARRWGDFLVRAREAWDRSRRPLLEEPLWPNWQVLAEREPYPAVPHKRFLRTRAARTLAEVGAWELREPRLIALLESHALAYGLDPRGTPASAAVLPYMEHAFGTWYVRGGMRELARAVYERCLARRVEFRFGAEVAGIVEKDGRAAGVELSDGTVAEADLVVAGVAPAVLERLGGGTRPRGDDGVPPQRGAASRLTVLLALRGGRPEGVAHRTVVHGEDRDAELESLFGPDPAVPARPTVTVLRPDDPALVPDAGHEAVTVTSVVPEGCGGSPDALAEHLVTAAERAVPGLRDRLLWHEVRTPADIAGETGAPGGAVPVPALAAADGRLLHPSNTTRLPGLFTAGGWSHPGGGLPHAGMSGALVAGLIVEGPDFRGSQ
>NZ_CP022310.1|WP_142195895.1|5817430_5818375_+|hypothetical-protein
MGWTVLYIAFGIVALWLLGEVLLQYKARLRWRLLAFAGFLGVVLGVLIPSVVVIGLGAAAFAVGQTYVTLSFRRGFAAGWAVNAPMLAAATGRRGDRGRREPAPEDLDTEVSGGYDDGDDHRDRTPPAADDDYDRDDVFTPVRPGQATAAETTAVYAPQPLPDETGSYGVYGSDPGYADPSQDQYAAAAHATDPNHAYDYSGYGQQQGYDTTGQQQYAAYSDPYIGNATYGGTGYDTGYADPQQYGQQGYAQDPYAGSYGGETPAGGLWVPQQRSPEDPYGNAELPPEQPYPYQGDGQTHGHGNGNGYDEQYRY
>NZ_CP022310.1|WP_142195894.1|5816450_5817374_+|methylenetetrahydrofolate-reductase-[NAD(P)H]
MALGTASTRTDRARTVRDMLATGRTTYSFEFWAPKTEKGERNLWNALRRVEAVAPSFVSVTYGAGGSTRAGTVKATEQIAADTTLTPVAHLTAVDHSIAELRNIIGQYADAGIRNMLAVRGDPPGDPMGDWVPHPQGLTYAAELVRLIKESGDFCVGVAAFPEMHPRSADWDTDVAHFVDKCRAGADYAITQMFFQPESYLRLRDRVDAAGCETPVIPEVMPVTSVKMLERLPKLSNASFPDALKERILTAKDDPAAVRSIGIEFATEFCARLLAEGVPGLHFITLNNSTATLEIYENLGLHHPPQS
>NZ_CP022310.1|WP_142233206.1|5815680_5816343_+|thiamine-phosphate-synthase
MTDTARARLADARVYLCTDARKRQGDLAEFLDAVLAGGVDIVQLRDKGMEAGEELEHLAVLADACARHGKLLAVNDRADVAHAAGADVLHLGQGDLPVPAARAILGDGILIGRSTHAESEAAAAAVQPGVDYFCTGPCWPTPTKPGRHAPGLDLVRYTAALRTDRPWFAIGGIDLGNLDQVLEAGARRVVVVRAITEADDPGAAAAAFAERLRHTAPDAG
>NZ_CP022310.1|WP_125507055.1|5815044_5815410_+|helix-turn-helix-domain-containing-protein
MTEIDAKIDALVPAWLTLPDIAERLGVEVTRVRQLVKEGQLIAVRRGENRALHVPAAFIDGDKVVKGLTGTLTLLRDDGFTVEEMLEWLFTPDPSLPGTPAQALSENRGTEVKRRAQALAV
>NZ_CP022310.1|WP_142234235.1|5813757_5814954_+|FAD-dependent-oxidoreductase
MVVAGAGMAGVQTAAALREQGFTGTVTLIGAEPHQPYDRPPLSKAVLLGTAEGSAFDVDFEDLGIDLRLGCEVLGLRPADHALDTEAGPVPYDVLVIATGAEPVRLPGSDGVPGVHLLRTLDDAERLRPVLARQQDIVVAGAGWIGAEFATAAREAGCAVTVVEAAQRPLAEALPAEVTAPMTAWYAEAGVVLRTHTRVARVEPGTVVLDDGSRLPAGAVVVGIGARPATAWLAGSGIELGERGEVVADRHLTTSLPDVYAVGDCASFPSGRYGERLLVHHWDNALQGPRTVAANILGSATGREPVVYDPVPYFWSEQFGRFVQYAGHHADADRTVWRGDPAAAAWSVCWLRGSRLVALLAVGRPRDLAQGRRLIEAGAAMDAELLADPARPLKSATA
>NZ_CP022310.1|WP_161175631.1|5825482_5826253_+|methyltransferase-domain-containing-protein
MSDPMRSRAALRTAVVRDVLQDALERRVKTTGRQALDVLDTGGGSGNFAVPLARLGHRVTVVDPSPNALFALERRAAEAGVADRVQGVQGDAHGLFDVAERGGYDAVLCHGVLEYVDDPAEGVRNAVAALRPGGVLSVLAASLGGAVLARALAGHFTEAQQALDDPNGRWGTGDPMPRRFTADQLTALVEGAGLRVGAVHGVRVFADLVPGVLVDTEPGALDALLKLEAAAAELPAFHSVATQLHVLGETEGDSEA
>NZ_CP022310.1|WP_142195901.1|5826543_5826948_+|DUF3040-domain-containing-protein
MPLSEHEQRMLEQMERALYAEDPKFATALEGSGLRTYTRRRVYQAVAGFLVGIALLMAGMVAQQVWLSVVGFLVMLGCAVLAVTGWRKAPKPGEQAAAGTPGAPQAGRQGRQRRSMMDRIEERWQRRRDEQGGH
>NZ_CP022310.1|WP_142234236.1|5827478_5829866_-|DUF4129-domain-containing-protein
MSGRARLALCAWAATLMTACALLPLVEPVSWIVQAALLLGVQSGVGAAARRVPLARPVTVALQVLVTLVLLTLVFARAHAFAGLFPGPDAFRFFADLLERGGNDVGRYAIPAPLSDGIRLMLVGGVLVIGLLVDTLAVTFRSAAPAGLPLLALYSVAAGLSDNGVEWLWFLLAAAGYLMLLLAEGRDRLAQWGRVFGTAARGPGSRPPGAAAPVRTGRRIGAVALGIALVVPLGLPSMNGGLLDAAGSRVGRGTGGSGTISEVSPLVSLQDSLNVDEDRQVMSVRTELTDVTDLYLRIVSLDEFDGTTWKPSKRSHTAVPQGPFPTPPGLGPGVGRTEVGTTISTADWYGQDWLPMPYPPSRVGVSGNWRYEPVGMTVAGAGGQDTRGLTYEVRSLLVQPTPEQLAGAPRPAPALEREYTELPDSLPAVVSRTAREVTEGADNAYERAVRLQEYFTLTGGFEYDTEVAVGSGAQGIARFLRDKQGFCMHFSFAMASMARSLGIPARVAVGFAPGTPQADGSVAVGLRDAHAWPELYFEGVGWTRFEPTPSRGSAPAYTVPDAADSSLPDPARPSRAAPDQPSAEPSRSESCTAEERKLEACGGESPQAAPPTDDDDRTWYVVPAWVLAGLALLVLPLAPMLWRMRIRAVRLGAHGRSEADAAPYVLSLWDELSDTAWDHGVPPDESLSPRGAAARIVRLGRLDPDAAASVHRVADAVEQVLYAPRPRPVAGLADEVRRAVAGLRAPVGRRTRLRAVLVPRSAVRVVWAVSAWWSGVRERVAGMRLAGRGPFRQRG
>NZ_CP022310.1|WP_142233211.1|5829865_5831227_-|DUF58-domain-containing-protein
MTTAGAVHGEGGAGERGGVRTALAGLTTRGRSFLAAGVAAAVCAYVLGQSDLLRVGLLLAVLPLVCATVLYRTRHRVAGSRGLSPGRVPAGSEARVHLRMENVSRMPTGLLMLQDRVPYVLGPRPRFLLDRVEAGGRREVSYRVRSDLRGRYPLGPLQLRLSDPFGMCELTRSFSAHDTLTVVPRVEPLPPVRLSGEAKGYGDGRQRSLALAGEDDVIPRGYRHGDDLRRVHWRSTARHGELMVRREEQPQRARCTVLLDTRAVAYAGAGPDSAFEWAVSGAASVLVHMLERGFSVRLLTDTGASVPGEGADGFAGASQESADAAGLMMDTLAVVDHSDEAGLSRAYDVLRGGNEGLLVAFLGDIDEDEAEVLARMRRRSGGALAFVLDSESWLREPAGVPGPPAVSGEGMRMLREAGWTALGVPRGAPLGELWRQADRERSGLAAAGGGEGP
>NZ_CP022310.1|WP_142195903.1|5831226_5832240_-|AAA-domain-containing-protein
MGDDLTAVVERVRGSVEGVIEGKPEVVRLSLTVLLAEGHLLIEDVPGVGKTMLAKALARSIDCSVRRIQFTPDLLPSDITGVSIWDQQRRDFEFKPGAIFAQVVIGDEINRASPKTQSALLESMEERQVTIDGKTYELPSPFMVVATQNPVEMEGTYPLPEAQRDRFMARVSVGYPSAEAELRMLDVHGGVSPLEDLQPVAHAHEILKLIEAVRGVHVAEPVRRYAVDLVAATRTHPDLRLGASPRATLHLLRAAKASAALCGREYALPDDVQALAVAVLAHRLLPTAQAQLNRRTAEQVVQEILQRTPVPAATGQQSGFGLGRGGQGYGQQPPRRL
>NZ_CP022310.1|WP_142195904.1|5832572_5833118_-|carbonic-anhydrase
MTTSASVPTGSGDTHGQGTVTDRLVEANQQYAAAFTDPGMDARPVLHVAVVACMDARLDLHDALGLSLGDCHTIRNAGGVVTDDVIRSLTISQRALGTRSVVLIHHTGCGLESLTEEFRHELEMEVGQRPSWAVEAFRDVDQDVRQSMQRVRTSPFLLHTDDVRGFVFDVKTGLLREVDPA
>NZ_CP022310.1|WP_142233212.1|5833536_5834493_+|16S-rRNA-(cytosine(1402)-N(4))-methyltransferase-RsmH
MSQSRHVPVMLQRCLDLLAPALERPGAVVVDCTLGLGGHSEALLRRFPEARLVALDRDKEALRLSGERLAPFGERATLVHAVYDELPDVLDRLGLPHVQGVLFDLGVSSMQLDEADRGFAYAQDAPLDMRMDQTTGISAAEVLNTYPPGELVRILRAYGEEKQAKRIVSAIVRERAKEPFTTSARLVELIRDALPQAAKRTGGNPAKRTFQALRIEVNGELSVLERAIPAAVKALDVGGRIAVLSYHSLEDRLVKQVFAAGAATTAPPGLPVVPEHHQPRLKLLTRGAELPTEEEIAENRRAAPARLRGAQRIREDVV
>NZ_CP022310.1|WP_142195906.1|5834592_5835138_+|hypothetical-protein
MSRKPEPRGKPGLPRQPELRGRAARLARLLPTGRAQAARTPFVLLVVLLLGGGLIGLLVLNSALSEGAFQLDDLQRETKNLTDEEQALQRDIDAYSAPDALQRRARELGMVPGGDPAFLSPDGKVKGVPSAASAVRAPMVLAPEALATATVPPPHSAPSPAGGAPAAPDPTPSASTSNPGR
>NZ_CP022310.1|WP_142195907.1|5835134_5837102_+|penicillin-binding-protein-2
MTEVSDREPPRRRVPGPARPARPGAGGRPGPGARPARRPAGPRAGAPKTIRLGSPRPRLRLIGVTLTLVLLAFVVRLFQVQAVDASTYASKAERNRYVGQVLAAERGEITDRNGVALATSEDAYDITADPTMFAPDELEIADGPEQAAALLAPILGQDQEDLVRKLRPENKALRYVKLAGRQTPQVWKQIKDLKAALAKKTETDESAANVLAGVFSVPTSKRVYPNNELAAGILGWVNAEGKGAGGVELQLDKRLAGKDGKIRYAQSGGRLVPTAGSTETPAVPGSDIELTIDRDIQWAAQNAISKQVKESVADRGYVIVQDTRTGEVLAMANAPGFDPNDLSEADPTALGNAALQDAYEPGSTAKVLSMAAVLEENAATPLTHVVVPNRLHRGDRLFKDDIDHPTWYLTLNGVLAKSSNIGTILATGQLGRTQAQANRVLYDYLRRFGFGSHTGLGFPGETKGILAPPDTWSTSQQYTIPFGQGVSINAMQAASVYSTIANGGVRIEPTLVRGAKGPDGRFTPAPKPKKTRVVSEKTAKTLARMLESVVDDEEGTGTKARIPGYRVAGKTGTANRVDPATGKYHGYTSSFAGFAPADKPRITVYCVIQNATEGNYFGGQICGPVYKQVMEFALKTLQVPPTGADPARIPVTFKP
>NZ_CP022310.1|WP_142233213.1|5837272_5838793_+|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,-6-diaminopimelate-ligase
MTYPGPPRPVHVSATSLAELAGQLGAPAPEKNVEVTGITHDSRAVRPGDLYAALPGARAHGADFVNQAAGLGAVAVLTDPAGAERAAAAGLPALVVEDPRGRMGELAATIYGHPGRDLLQIGITGTSGKTTTAYLVEGGLRTVRSTGLIGTVEMRIGDERIKSERTTPEATDLQALFAVMRERGTEAVAMEVSSHALVLGRVDGCVFDTAVFTNLSPEHMEFHSDMEDYFRAKAQLFTPERSKLGVVNADDEYGRRLAREAGVPVVTYSAEGHPDADWRADDVQVGPMDATFTVIGPKDERIAARSPLPGTFNVANTLAAIVALAAAGLDPQAAADGIAAVPGVPGRLERVDAGQPYLAVVDYAHKTDAVESVLRALRRVTEGKVHVVLGCGGDRDTTKRAPMGAAVARLADTAVLTSDNPRSEDPLAILATMLQGAASVPAHERGEVQVFEDRAAAIAAAVARARPGDTVLVAGKGHEQGQDIAGVVRPFDDRQVLREAIKKTQG

Crispr_ID: NZ_CP022310_18

• CRISPR_ID: NZ_CP022310_18
• CRISPR_location: 6503679-6503871
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: DEDDh

Consensus repeat of NZ_CP022310_18

Consensus_repeat	Method
CGTCCGGATGCGGACGCGGACGCCCGCACCAACCGGCTGATCCGGTTG	CRISPRCasFinder

spacers of NZ_CP022310_18

>18.1|6503727|97|NZ_CP022310|CRISPRCasFinder
CAGACGCCCCACGTCATCCGGCCCGTCCGGATGCGGACGCGGACGCCCGCACCAACCGGCTGATCCGGTTGTGACGGACGCCCCACGTCATCCAGCT

CRISPR arrays and Neighbor proteins around NZ_CP022310_18

CRISPR arrays

The CRISPR arrays of NZ_CP022310_18

>merge|NZ_CP022310|18|6503679-6503871|CRISPRCasFinder
CGGCCGATCCGGATCGCGGACGCCCGGATCGTCCGGCCGGTCCGGATGCAGACGCCCCACGTCATCCGGCCCGTCCGGATGCGGACGCGGACGCCCGCACCAACCGGCTGATCCGGTTGTGACGGACGCCCCACGTCATCCAGCTCGTCCGAATGCGGACGCGGACGCCCGCACCAACCGGCTGATCCGGTTG

>NZ_CP022310|18|16|6503679-6503871|CRISPRCasFinder
CGGCCGATCCGGATCGCGGACGCCCGGATCGTCCGGCCGGTCCGGATG	CAGACGCCCCACGTCATCCGGCCCGTCCGGATGCGGACGCGGACGCCCGCACCAACCGGCTGATCCGGTTGTGACGGACGCCCCACGTCATCCAGCT
CGTCCGAATGCGGACGCGGACGCCCGCACCAACCGGCTGATCCGGTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142233465.1|6513489_6514242_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|234640
NZ_CP022310.1|WP_142196488.1|6511230_6511773_+|LemA-family-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233457.1|6494793_6497529_+|Tat-pathway-signal-sequence-domain-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142196481.1|6501048_6503025_+|threonine--tRNA-ligase	unknown	unknown	gnl|CDD|237050
NZ_CP022310.1|WP_142233459.1|6498243_6498969_-|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl|CDD|181176
NZ_CP022310.1|WP_142233463.1|6510006_6511170_+|glycosyltransferase	unknown	unknown	gnl|CDD|340831
NZ_CP022310.1|WP_142233455.1|6493214_6494105_+|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223472
NZ_CP022310.1|WP_142233464.1|6512832_6513441_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	unknown	unknown	gnl|CDD|237411
NZ_CP022310.1|WP_142233456.1|6494115_6494694_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142196483.1|6503998_6505654_-|hypothetical-protein	unknown	unknown	gnl|CDD|376764
NZ_CP022310.1|WP_167530135.1|6492216_6493218_+|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|224096
NZ_CP022310.1|WP_142233462.1|6509065_6510010_+|phosphatidylinositol-mannoside-acyltransferase	unknown	unknown	gnl|CDD|236131
NZ_CP022310.1|WP_142233458.1|6497563_6498013_+|polyketide-cyclase	unknown	unknown	gnl|CDD|176866
NZ_CP022310.1|WP_093768304.1|6511913_6512825_+|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	unknown	unknown	gnl|CDD|179769
NZ_CP022310.1|WP_142233460.1|6499700_6500957_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142196482.1|6503106_6503655_+|HIT-domain-containing-protein	unknown	unknown	gnl|CDD|238606
NZ_CP022310.1|WP_142233461.1|6505870_6508069_-|elongation-factor-G-like-protein-EF-G2	unknown	unknown	gnl|CDD|237186
NZ_CP022310.1|WP_142233466.1|6514349_6514916_+|crossover-junction-endodeoxyribonuclease-RuvC	unknown	unknown	gnl|CDD|234587
NZ_CP022310.1|WP_142196479.1|6499137_6499704_+|DUF4365-domain-containing-protein	unknown	unknown	gnl|CDD|379535
NZ_CP022310.1|WP_142196485.1|6508367_6509069_+|CDP-alcohol-phosphatidyltransferase-family-protein	unknown	unknown	gnl|CDD|223632

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022310.1|WP_142233459.1|6498243_6498969_-|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	4.1e-34	112.8	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233465.1|6513489_6514242_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl|CDD|234640	PRK00110, PRK00110, YebC/PmpR family DNA-binding transcriptional regulator.	1.67626e-146
NZ_CP022310.1|WP_142233464.1|6512832_6513441_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	gnl|CDD|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	2.4787e-117
NZ_CP022310.1|WP_142196481.1|6501048_6503025_+|threonine--tRNA-ligase	gnl|CDD|237050	PRK12305, thrS, threonyl-tRNA synthetase; Reviewed.	0
NZ_CP022310.1|WP_142233459.1|6498243_6498969_-|3'-5'-exonuclease	gnl|CDD|181176	PRK07942, PRK07942, DNA polymerase III subunit epsilon; Provisional.	4.98398e-114
NZ_CP022310.1|WP_142233463.1|6510006_6511170_+|glycosyltransferase	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	1.35912e-74
NZ_CP022310.1|WP_142233455.1|6493214_6494105_+|ABC-transporter-permease-subunit	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	5.97449e-86
NZ_CP022310.1|WP_142196483.1|6503998_6505654_-|hypothetical-protein	gnl|CDD|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	0.00586132
NZ_CP022310.1|WP_167530135.1|6492216_6493218_+|ABC-transporter-permease-subunit	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.59821e-80
NZ_CP022310.1|WP_142196482.1|6503106_6503655_+|HIT-domain-containing-protein	gnl|CDD|238606	cd01275, FHIT, FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.	4.62438e-66
NZ_CP022310.1|WP_142233461.1|6505870_6508069_-|elongation-factor-G-like-protein-EF-G2	gnl|CDD|237186	PRK12740, PRK12740, elongation factor G-like protein EF-G2.	0
NZ_CP022310.1|WP_093768304.1|6511913_6512825_+|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	gnl|CDD|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	0
NZ_CP022310.1|WP_142233466.1|6514349_6514916_+|crossover-junction-endodeoxyribonuclease-RuvC	gnl|CDD|234587	PRK00039, ruvC, Holliday junction resolvase; Reviewed.	6.88384e-83
NZ_CP022310.1|WP_142233462.1|6509065_6510010_+|phosphatidylinositol-mannoside-acyltransferase	gnl|CDD|236131	PRK07920, PRK07920, lipid A biosynthesis lauroyl acyltransferase; Provisional.	1.32922e-157
NZ_CP022310.1|WP_142233458.1|6497563_6498013_+|polyketide-cyclase	gnl|CDD|176866	cd07824, SRPBCC_6, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	3.29828e-43
NZ_CP022310.1|WP_142196479.1|6499137_6499704_+|DUF4365-domain-containing-protein	gnl|CDD|379535	pfam14280, DUF4365, Domain of unknown function (DUF4365). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 182 and 530 amino acids in length. There is a single completely conserved residue D that may be functionally important.	3.00516e-27
NZ_CP022310.1|WP_142196485.1|6508367_6509069_+|CDP-alcohol-phosphatidyltransferase-family-protein	gnl|CDD|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	3.37006e-25

Protein sequences

>NZ_CP022310.1|WP_142196482.1|6503106_6503655_+|HIT-domain-containing-protein
MTSEPEQQLGVGTQDAFQRLWTPHRMAYIQGENKPTGPGADDGCPFCSIPAKSDEDGLVLRRGELVYAVLNLYPYTGGHLMTVPYRHVADYTDLTVEETAELAELTKQAMTALRTASGAHGFNIGMNQGTVAGAGIAAHLHQHVVPRWGGDTNFMPVVGHTKVLPQLLADTRKMLADAWPTD
>NZ_CP022310.1|WP_142196481.1|6501048_6503025_+|threonine--tRNA-ligase
MSDVRVIIQRDSEREERVVTTGTTAAELFAGERSIIAARVAGELKDLSYEVEDGETVEGVEISSEDGLNILRHSTAHVMAQAVQELFPEAKLGIGPPVRDGFYYDFDVDKPFTPEDLKAIEKKMQEIQKRGQRFSRRVVSDDAAREELAGEPYKLELIGLKGAASHDDGADVEVGAGELTIYDNLDAKTGELCWKDLCRGPHLPTTRNIPAFKLMRNAAAYWRGSEKNPMLQRIYGTAWPSKDELKAHLEFLAEAEKRDHRKLGSELDLFSIPEQIGSGLAVFHPKGGIVRRVMEDYSRRRHEEEGYEFVYTPHATKGKLFETSGHLDWYADGMYPPMQLDEGVDYYLKPMNCPMHNLIFDARGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRARGFTQDDAHIYCTREQMSEELDRTLTFVLNLLRDYGLTDFYLELSTKDPEKFVGSDEAWEEATETLRQVAEKQGLPLVPDPGGAAFYGPKISVQAKDAIGRTWQMSTIQLDFNLPERFDLEYTAADGSKTRPVMIHRALFGSIERFFAVLLEHYAGAFPAWLAPVQAIGIPIGDAHVEYLEKFADAARKQGLRVEVDSSSDRMQKKIRNAQKQKVPFMVIAGDEDMANGAVSFRYRDGSQENGIPVDEAIAKIAKVVEERTQV
>NZ_CP022310.1|WP_142233460.1|6499700_6500957_+|hypothetical-protein
MTHRPTPPPLRPVRRHPAESAFTQSAFGESALDGRPPDPADTDPAVLTALLHRHGWQRRGGAPGRYGRWTPPGPGTGTSLLVPVSRAFPDSEDLLAEALLALSRSGTPSAREILLSLAVPSDEIHWERDTPAGPGGATAWTAEEQLRSAARRTLLAAALATRARAGFHGARNRRAAAAVLEDVLVGPAPGGRRLTAFAPVTTGRSLAVCLHQALHATREAIDYRRATGGMDAFDTAVAVGVSHELTEALVALVRGTEGARIGVAWAPAAGVPEGCAATAEPVEFSAGDLTVLREAGLRYQRAEPSVTVRLTGAVVRMHRSGPRGEGMVRLRVLAGADIGHVRIVLGEEDYRIAGHAHLVGLPVRVRGRLQSRGGFRRLTEAGELAPVQVDEAERERLMKALQENLEFFGEACGPECAD
>NZ_CP022310.1|WP_142196479.1|6499137_6499704_+|DUF4365-domain-containing-protein
MAIAQPERGGLLPERTPPARGTLATTACMETLQVGYLHAVAAAAGCSLSQPFPDNGIDWHVSHSAAGHTVDDEVTIKVQLKATYQVAPNPPGRFFSFTLDNAHLAKLARTPVTVHKILVVMIVPRSQDDWLRAGHDRLDLRHCCYWTNLAGHPLTGRTRTTVRIPTSRIFDDRALCEIMTRVGTGGKP
>NZ_CP022310.1|WP_142233459.1|6498243_6498969_-|3'-5'-exonuclease
MTCWYEGPLAAFDTETTGVDVETDRIVSAALVVQDAPGTRPRVTRWLVNPGVPVPAAATEVHGLTEEHLQRNGRWPAPVMYEVAEALAEQARVGRPVVVMNAPFDLTLLDRELRRHRASSLDRWIERSPLLVLDPRVLDKHLDRYRKGRRTLTDLCAHYGVALEGAHDAAADAVAALEVTRAVGRRFASRLERLSPRELHTLQAVWHAAQARGLQEWFARSGTGEVVDPAWPLRPGLPAAA
>NZ_CP022310.1|WP_142233458.1|6497563_6498013_+|polyketide-cyclase
MDWNHYRFRSLWTLTAPAPVVHQALARIEDYPLWWPQVREVTRLDDTGAAVRIRSLLPYDLFLTMREERRDPEAGVLEAAILGDLEGWARWSVTARPAGGCLVRYDQEVEVRKPLMRRLAVPGRPFFRANHALMMRAGRRGLVRHLEAV
>NZ_CP022310.1|WP_142233457.1|6494793_6497529_+|Tat-pathway-signal-sequence-domain-protein
MSPIPRRSLLKAAAVAGAAAQFSWALGSQNAAAAPRDEAAAADPVTLDWLEEGGLGAAPGSTVGVPWPRGAHQEDQTFAVTDADGTSVPVQSWPIAYWPDGSLKWTAHAVSSGTGKLTVAAGTPAAPEKKVTVDRRGGTVDVSTGVITARIGTSGATIVKSVTRGSTEIARNGRLVVLRQPELEDGDQTTVRTERFDGTVSEVTVEQDGPVRAVVRIDGKHRRGSRGWLPFSVRLYFYAGADSFRMVHTITYDGTQEPGKASGDFVRGIGVRFSVPMRDESYDRHIRIGGEGTGLLREAVKGITGLRRDPGIAVQQAQFDGKKLPDPSTWDQRVTSRLQYIPEWGDYTLSQLSADGFALRKRTKKGHGWIAAGGGRRASGFGYVGGVSGGFSFGLRDFWEKHPAQLDIRGAHTDEAEVTLWLWSPEAQPMDLRFYHDGMGQDTFPEQLEGLNITYEDYEPGFGTPYGIARTSELLFWANESTPGADRLAQQVEAVRVLPQLAAPPAQLIRAGVFGKGLYSEPDRSTPAKAKIEDHLDFLFTYYKDQVEQRRWYGFWDYGDIMHTYDTVRHQWRYDVGGYAWDNSELSPDLWLWYAYLRSGRADIFRFAEAMTRHTGEVDVYHLGKWAGLGTRHGVQHFADSAKQQRIANTTYRRYYYFLTADERVGDLMHANVDSDETFLALDPLRKIRTEPYTPDRNALSVGFGTDWSGLVSAWLTEWERRGPKWEKARARVLSTMETIAAQPNGFVQGSGLYDLDTGKFAVAGTPKVEVSHLSAVFGLNELCAELIDLVDMPEFAEAYYDYCRYYNATKAEQAARYGAHFGSLILFQGHSRLDAYAAVRTGDDKLAERAWAKFYDSDGYKESAPWKTEKVTGPTALVAGSEATWVSTNDTALYGLAAIENLALLGDRMP
>NZ_CP022310.1|WP_142233456.1|6494115_6494694_+|hypothetical-protein
MSLARTESRFWGRFALFAECLLTGVWIAVAALPLVTYPAALAAGARHLGRHLAHEPGGWREFAADFRSAVRGGWIVGLAGWAAVAAVWFDLRAVRAGLPGGALVGAVGVFALIGAAAALLRAAALWRPGTSWRPLLARAGRHTVLDPAGSFLIIGGLAVVACSAWFSAPLAVPVLGAVAAAAVAVEERYRHR
>NZ_CP022310.1|WP_142233455.1|6493214_6494105_+|ABC-transporter-permease-subunit
MSAQATDITPAPSSKGALRRRLPGSLAWHLGSLAILAVILYPVVWVVGGSFKKSEDIVGSLDLFPADPIVDNYTSLTDGIADISISTFFVNSLLLAVGSVVGILISCSLTAYAFAKIRFAGRNLLFTLMIGTLLLPYHVLLIPQYVLFRNMDMINTYTPLLLGKYLATEAFFVFLMVQFMRNLPKELDEAARLDGCGHVRIYWSIVLPLCRPALITSAIFTFINAWNDFMGPLIYLNEPGKYTVSLGLKMFVDQEGLANYGGMIAMSLVALLPVLAFFLAFQRYLIDGMATSGLKG
>NZ_CP022310.1|WP_167530135.1|6492216_6493218_+|ABC-transporter-permease-subunit
MGTAVTHAPATEHLAKDSEPRHGPVKSPSPTALARRGRRENLAGYLFMSPWIAGFLLLTAGPMVASLYFAFTDYNLFDAPQWIGLDNFSEMFADPRWRHSVQVTLWYVVVGTPIKLIAALGVALLLAQKRRGQAFYRAAFYAPSLIGASVSVAIVWKAIFSDDAIVDRTQKIFGIDVGGWTGDPDMIIYSLVALTVWQFGAPMVIFLAGLKQVPRELYEAADVDGAGKLRQFWNITLPMISPVLFFNVLLETIHSFQIFSSAYIVGGGAGGNACGPADGSMVYTCYLYVQGFENSRMGLASAMAWMLLVAVALVTAVLFWSQKRWVHYEEGGR
>NZ_CP022310.1|WP_142196483.1|6503998_6505654_-|hypothetical-protein
MTVEGGYAEFFGPQVPRTGDEGQTPTFALASAAYRDNEAEEILKANNEWHKSAVSKPRLALFRPNLGEAFSRALIDRMLGPGRAPLIQSFGTQPQVVVEHALAAHRIRRDRDNWLSAIMVLCGVLFLPGLLMWLLVFQIRTTMAKREDKRAGVLATVLLLAVAALAVLFLIRMPFGGFWGWYARAAVVAPVVGWFWAKRICERTAHDLRERWSGLLSGSSVGAKVPEAVPSSPGETAAEALRQSLARLSAEQQSNSVFYAGPKGILGMGTRWGSWQLAEDLVPADPGREINPFRSWDVVRAIHDQLRMLERGPLHTGGFPKPSVRHWIVTPIGENAGSVSRPDGTDVEAYQVKPHAVQEICNKQQFGAGDRHYLGVQWTLWDGQLVITMLITVTVLHETLRIEVTGHALGPVHSLFTSKPAAKEKEVQKSIKFWETRKIKLPLVDSDEVVRLAARAPLTWYPPLLYWLGGKLSLPEPFGLRHAWADKPWRHRFMADDALRAATPVLRVVHSAAIKVLEENGVDTTKFGARSSSLSTAVQEATPKKADVYDA
>NZ_CP022310.1|WP_142233461.1|6505870_6508069_-|elongation-factor-G-like-protein-EF-G2
MGDKAHTHPGAAGRAQAADHPASLRNVVLVGHSGSGKTTLVEALALTAGAVNRAGRVEDGGTVSDYDEIEHRQQRSVQLSLVPLEWDGIKVNLLDTPGYADFVGELRAGLRAADAALFVVSASDGVDGSTRMVWDECAAVGMPRAIVVTHLEAARADFEEMTRVCAEAFGGDDPDAVLPLYLPLRGPEGPDGHAPVHGLIGLLSQKLFDYSGGERKESEPGEEHLPLIEEARGRLIEGIIAESEDETLMDRYLGGEQVDVKTLIEDLERAVARGVFFPVLAAAPAAAGARQGLGTVELLELITRGFPTPLEHGTPRVTTLDGRPRDLAPCDPDAPLVAEVVKTSSDPYVGRISLVRVFSGTLRADQTVHVSGHGLADRGHEDHDVDERIGALSTPFGKQQRPVSHVIAGDLACVAKLGRAETGDTLSAKDDPLLMEPWEMPDPLLPLAIQAHSKPDEDKLSQGLARLVAEDPTMRLEQNQDTHQVVLWCLGEAHADVALERLRSRYGVQVDVVPHRVSLRETFGQKAAGRGRHVKQSGGHGQFAICEIEVEPLPNGSGIEFVDKVVGGAVPRQFIPSVEKGVRAQAAKGVAAGHPLIDVRVTLLDGKAHSVDSSDAAFQTAGALALREAAADARIHLLEPVAEVSVLVGDDYVGAVMSDLSGRRGRVLGTEQSPAGRTLVRAEVPEIEIGRYAVDLRSLSHGTARFSRRYARHEPMPPQIAERVKEEARSAS
>NZ_CP022310.1|WP_142196485.1|6508367_6509069_+|CDP-alcohol-phosphatidyltransferase-family-protein
MLNKYARAFFTRVLTPFAAFLIRRGVSPDTVTLIGTAGVVAGALVFYPRGEFFWGTVVITLFVFSDLVDGNMARQLGRSSRWGAFLDSTLDRVADGAVFGGFALWYAGNGDDNVLCAVSIFCLASGQVVSYTKARGESIGLPVAVNGLVERAERLVVSLVAAGLAGLHAFGVPGIQYLLPVALWIVAVGSLVTLIQRVVTVRRESAEAEAADAEAADAEAAGRQETRGSEAAK
>NZ_CP022310.1|WP_142233462.1|6509065_6510010_+|phosphatidylinositol-mannoside-acyltransferase
MSAQQRLTDALYGAGWGTVKRLPEPVAVRLGRTIADLAWKQRGAGVQRLERNYARVVPGATPERLAELSRAGMRSYLRYWMESFRLPAWSAERIAAGLDLKDLHHLTDGMAAGKGVIAALPHLANWDLAGAWVTTKLGIPFTTVAERLKPETLYDRFVAYREGLGMEVLPHNGGSAFGTLARRLRDGGLVCLVADRDLSASGVEVDFFGERARMPAGPALLAQHTGARLLPVTLWYDDSPVMRGRLHPPVEVPESGTRSEKTSAMTQALADAFATGIAEHPEDWHMLQRLWTADLDPARDPATAASQQDRKGTS
>NZ_CP022310.1|WP_142233463.1|6510006_6511170_+|glycosyltransferase
MRIGIVCPYSWDVPGGVQFHIRDLAEYFIRLGHEVSVLAPADDDTPLPPYVVSAGRAVPVPYNGSVARLNFGFLSAARVRRWLHDGAFDVVHIHEPTSPSLGLLTCWAAEGPIVATFHTSNPRSRAMIAAYAILQAALEKISARIAVSEYARRTLVEHLGGDAVVIPNGVDVDFFAKAEPRPEWQGDTIGFIGRIDEPRKGLPVLMKALPKILAARPQTRLLVAGRGDEEEAVESLPKELRSRVEFLGMISDEDKARLLRSVDVYVAPNTGGESFGIILVEAMSAGAPVLASDLDAFAQVLDRGAAGELFANEDADALADAAVRLLADPERRAELREHGSAHVRRFDWSTVGADILSVYETVTAGAAAVAADDRATGLRARFGLARD
>NZ_CP022310.1|WP_142196488.1|6511230_6511773_+|LemA-family-protein
MTATLIWILVALVATGLYLSWTAGRLDRLHARIDAARAALDAQLLRRASVAQELATSGVLDPAASIVLYEAAHAARQAVEEQREVAESELSQALRAVFADAPQVDAVREAPGGEDAALELAEAVRRVPMARRFHNDAVRAARALRRHRKVRWFRLAGHAPFPMAFEMDDEPPAALVERAA
>NZ_CP022310.1|WP_093768304.1|6511913_6512825_+|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS
MSSTLSENQGPETGTARVKRGMAEQLKGGVIMDVVTPEQAKIAEDAGAVAVMALERVPADIRKDGGVARMSDPDMIEGIIDAVSIPVMAKSRIGHFVEAQVLQSLGVDYIDESEVLTPADEVNHSDKWAFTTPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGNVVEAVRHLRQIKNEIARLRGYDNHELYAAAKELRAPYELVKEVAELGKLPVVLFSAGGVATPADAALMRQLGAEGVFVGSGIFKSGDPAKRAAAIVKATTFYDDPKIIADASRNLGEAMVGINCDTLPEAERYANRGW
>NZ_CP022310.1|WP_142233464.1|6512832_6513441_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT
MTEAPVIGVLALQGDVREHLVALAAADAVARPVRRPEELAEVDGLVVPGGESTTISKLAVLFGLMEPLRTRVREGMPVYGTCAGLIMLADKILDPRSGQETIGGIDMIVRRNAFGRQNESFEAAVDVKGVTGDPVEGVFIRAPWVESVGAGAEVLAEHDGHIVAVRQGNALATSFHPELTGDHRVHGLFVDMVRANRAAESL
>NZ_CP022310.1|WP_142233465.1|6513489_6514242_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MSGHSKWATTKHKKAVIDAKRGKLFAKLIKNIEVAARMGGADPDGNPTLYDAIQKAKKQSVPNKNIDSAVKRGAGLEAGGADYETIMYEGYGPNGVAVLIECLTDNRNRAASDVRVAMTRNGGSMADPGSVSYLFNRKGVVIVPKGELTEDDVLTAVLDAGAEEVNDLGENFEVISEATDLVAVRTALQDAGIDYESADANFVPTMQVELDEEGAKRIFKLIDALEDSDDVQNVFANFDVSDEIMEKVDA
>NZ_CP022310.1|WP_142233466.1|6514349_6514916_+|crossover-junction-endodeoxyribonuclease-RuvC
MRVLGVDPGLTRCGVGVVEGVAGRPLTMLGVGVVRTPADADLGHRLVAVEQGLEQWLDEHRPEFVAVERVFSQHNVRTVMGTAQASAVAILCASRRGIPVALHTPSEVKAAVTGSGRADKAQVGAMVTRLLRLDAPPKPADAADALALAICHIWRAPAQNRLQRAVALHTAKAPQSPNAPHASKGRTA

Crispr_ID: NZ_CP022310_19

• CRISPR_ID: NZ_CP022310_19
• CRISPR_location: 6562488-6562693
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP022310_19

Consensus_repeat	Method
CGNCCCCGGNNGCTCGCCGCC	CRT

spacers of NZ_CP022310_19

>19.1|6562509|25|NZ_CP022310|CRT
GCGACGCCCAGGCCACCGGGACTGT
>19.2|6562555|25|NZ_CP022310|CRT
TTGATGCCTAGGCCACCGCGACTGT
>19.3|6562601|26|NZ_CP022310|CRT
CCGACGCCCAGAATCTTCATGACTGC
>19.4|6562648|25|NZ_CP022310|CRT
TTGATGCCTAGGCCACCGGGACTGC

CRISPR arrays and Neighbor proteins around NZ_CP022310_19

CRISPR arrays

The CRISPR arrays of NZ_CP022310_19

>merge|NZ_CP022310|19|6562488-6562693|CRT
CCGCCCCAGGCGCTCGGCGCCGCGACGCCCAGGCCACCGGGACTGTCGTCCCTGGGCGCTCGCCGCCTTGATGCCTAGGCCACCGCGACTGTCGCCCTCGGTTGCTCGCCGCCCCGACGCCCAGAATCTTCATGACTGCCGTCCCCGGTTGCTCGCCGCCTTGATGCCTAGGCCACCGGGACTGCCGTTCCCGTTTGCTCGCCGCA

>NZ_CP022310|19|3|6562488-6562693|CRT
CCGCCCCAGGCGCTCGGCGCC	GCGACGCCCAGGCCACCGGGACTGT
CGTCCCTGGGCGCTCGCCGCC	TTGATGCCTAGGCCACCGCGACTGT
CGCCCTCGGTTGCTCGCCGCC	CCGACGCCCAGAATCTTCATGACTGC
CGTCCCCGGTTGCTCGCCGCC	TTGATGCCTAGGCCACCGGGACTGC
CGTTCCCGTTTGCTCGCCGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_003977346.1|6555828_6556152_+|integration-host-factor	unknown	unknown	gnl|CDD|223177
NZ_CP022310.1|WP_142233490.1|6564708_6566127_+|rRNA-cytosine-C5-methyltransferase	unknown	unknown	gnl|CDD|237857
NZ_CP022310.1|WP_167530136.1|6554726_6555572_+|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl|CDD|234651
NZ_CP022310.1|WP_142196531.1|6563700_6564633_+|methionyl-tRNA-formyltransferase	unknown	unknown	gnl|CDD|234567
NZ_CP022310.1|WP_142196536.1|6568476_6568830_+|barstar-family-protein	unknown	unknown	gnl|CDD|376530
NZ_CP022310.1|WP_142233489.1|6562922_6563471_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142196527.1|6557239_6558442_+|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	unknown	unknown	gnl|CDD|235513
NZ_CP022310.1|WP_142196539.1|6572191_6572644_+|AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_CP022310.1|WP_142196528.1|6558680_6559889_+|methionine-adenosyltransferase	unknown	unknown	gnl|CDD|235374
NZ_CP022310.1|WP_142233487.1|6556189_6556783_+|guanylate-kinase	unknown	unknown	gnl|CDD|234719
NZ_CP022310.1|WP_142233488.1|6560000_6562148_+|primosomal-protein-N'	unknown	unknown	gnl|CDD|237844
NZ_CP022310.1|WP_142196533.1|6566244_6566931_+|ribulose-phosphate-3-epimerase	unknown	unknown	gnl|CDD|235515
NZ_CP022310.1|WP_142233485.1|6550264_6553573_+|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl|CDD|235393
NZ_CP022310.1|WP_142196535.1|6568093_6568480_+|ribonuclease-N	unknown	unknown	gnl|CDD|238340
NZ_CP022310.1|WP_142233486.1|6553623_6554730_+|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl|CDD|235388
NZ_CP022310.1|WP_167530212.1|6568937_6570380_+|GuaB1-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl|CDD|181127
NZ_CP022310.1|WP_142233492.1|6570702_6572181_+|amino-acid-permease	unknown	unknown	gnl|CDD|129987
NZ_CP022310.1|WP_142233484.1|6549129_6550272_+|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl|CDD|237139
NZ_CP022310.1|WP_004933985.1|6556845_6557118_+|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl|CDD|234744
NZ_CP022310.1|WP_142196534.1|6567009_6568053_+|transcriptional-regulator	unknown	unknown	gnl|CDD|367868

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_003977346.1|6555828_6556152_+|integration-host-factor	gnl|CDD|223177	COG0099, RpsM, Ribosomal protein S13 [Translation, ribosomal structure and biogenesis].	1.33846e-05
NZ_CP022310.1|WP_142233490.1|6564708_6566127_+|rRNA-cytosine-C5-methyltransferase	gnl|CDD|237857	PRK14902, PRK14902, 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB.	1.63101e-92
NZ_CP022310.1|WP_167530136.1|6554726_6555572_+|orotidine-5'-phosphate-decarboxylase	gnl|CDD|234651	PRK00125, pyrF, orotidine 5'-phosphate decarboxylase; Reviewed.	2.88344e-124
NZ_CP022310.1|WP_142196536.1|6568476_6568830_+|barstar-family-protein	gnl|CDD|376530	pfam01337, Barstar, Barstar (barnase inhibitor).	2.90847e-26
NZ_CP022310.1|WP_142196527.1|6557239_6558442_+|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC	gnl|CDD|235513	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated.	0
NZ_CP022310.1|WP_142196539.1|6572191_6572644_+|AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	4.07336e-29
NZ_CP022310.1|WP_142196528.1|6558680_6559889_+|methionine-adenosyltransferase	gnl|CDD|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP022310.1|WP_142196531.1|6563700_6564633_+|methionyl-tRNA-formyltransferase	gnl|CDD|234567	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed.	5.43507e-167
NZ_CP022310.1|WP_142233487.1|6556189_6556783_+|guanylate-kinase	gnl|CDD|234719	PRK00300, gmk, guanylate kinase; Provisional.	5.82834e-107
NZ_CP022310.1|WP_142233488.1|6560000_6562148_+|primosomal-protein-N'	gnl|CDD|237844	PRK14873, PRK14873, primosomal protein N'.	0
NZ_CP022310.1|WP_142196533.1|6566244_6566931_+|ribulose-phosphate-3-epimerase	gnl|CDD|235515	PRK05581, PRK05581, ribulose-phosphate 3-epimerase; Validated.	2.87242e-136
NZ_CP022310.1|WP_142233485.1|6550264_6553573_+|carbamoyl-phosphate-synthase-large-subunit	gnl|CDD|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP022310.1|WP_142196535.1|6568093_6568480_+|ribonuclease-N	gnl|CDD|238340	cd00607, RNase_Sa, RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate specific endoribonuclease which belongs to the superfamily of microbial ribonucleases. Typical of this sub-family, the enzyme hydrolyses the phosphodiester bonds of RNA at the 3' oxygen end of guanosine residues to yield oligonucleotides with the guanosine-2',3'-cyclophosphate at the 3' end and the hydroxyl group at the 5' end. The terminal guanosine-2,3'-cyclophosphate is hydrolysed by guanyl RNAses to give guanosine-3'-phosphate.	2.43029e-42
NZ_CP022310.1|WP_142233486.1|6553623_6554730_+|quinone-dependent-dihydroorotate-dehydrogenase	gnl|CDD|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	0
NZ_CP022310.1|WP_167530212.1|6568937_6570380_+|GuaB1-family-IMP-dehydrogenase-related-protein	gnl|CDD|181127	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein.	0
NZ_CP022310.1|WP_142233492.1|6570702_6572181_+|amino-acid-permease	gnl|CDD|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	0
NZ_CP022310.1|WP_142233484.1|6549129_6550272_+|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl|CDD|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NZ_CP022310.1|WP_004933985.1|6556845_6557118_+|DNA-directed-RNA-polymerase-subunit-omega	gnl|CDD|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	2.13383e-18
NZ_CP022310.1|WP_142196534.1|6567009_6568053_+|transcriptional-regulator	gnl|CDD|367868	pfam04198, Sugar-bind, Putative sugar-binding domain. This probable domain is found in bacterial transcriptional regulators such as DeoR and SorC. These proteins have an amino-terminal helix-turn-helix pfam00325 that binds to DNA. This domain is probably the ligand regulator binding region. SorC is regulated by sorbose and other members of this family are likely to be regulated by other sugar substrates.	1.25335e-75

Protein sequences

>NZ_CP022310.1|WP_142233488.1|6560000_6562148_+|primosomal-protein-N'
MSSENGQRDGGAQGAPPEQLALIRESVRRAKAPRAKPRTWRGAALAGNLPVARVLVDKGVLHLDRYFDYAVPEELDADAQPGVRVRVRFGAGRHRVREGRREGGGLIDGFLVERLAESDYSGPLAALAQVVSPERVLSEELLGLARAVADRYAGSLADVLQLAVPPRNARAEKRPSPDPLPPPPAPAPGPWERYEQGPAFLESLATGGAPRAVWNALPGPLWSEELARAVAATLASGRGALVVVPDGRAVARVDAALTELLGRGRHAVLTADAGPEKRYAQWLAVRRGSVRAVVGTRAAMFAPVRDLGLVAVWDDGDDSHSEQHAPQPHAREVLLLRAAQDKCGFLLGGWSCTVEAAQLVDTGWARPLVATRERVRAAAPLVRTVGDQDLARDEAARAARLPTLAWQAVREGLRHGPVLVQVPRRGYVPRMACAACRAPARCRHCSGPLEARGADDLRCGWCGREESGWHCPECGGFRLRAQVVGARRTAEELGRAFPAVPVRTSGREQVLDTVPGAPALVVSTPGAEPVAEGGYAAALLLDGWAMLGRPDLRAGEDALRRWIAAAALVRPQSAGGTVVVVAEPTLRPVQALVRWDPVGHAVRELAERGELGFPPVSRMASVSGPGPAVAAFLRAVALPPSAEVLGPVPLPVTPAGRPRRPGAPPPGEEWERALIRVPPGTGAALAGALKAAQAARTARGGDEPVWVRIDPPDIG
>NZ_CP022310.1|WP_142196528.1|6558680_6559889_+|methionine-adenosyltransferase
MSRRLFTSESVTEGHPDKIADQISDTILDALLREDPTSRVAVETLITTGLVHVAGEVTTKTYADIANLVRGKILEIGYDSSKKGFDGASCGVSVSIGAQSPDIAQGVDAAYEARVEGDDDELDRQGAGDQGLMFGYATDETPTLMPLPIFLAHRLSKRLSDVRKNGTIPYLRPDGKTQVTIEYDGDKAVRLDTVVVSSQHASDIDLESLLAPDIREFVVEPELKALLDEGIKLDTENYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLASRCEVQVAYAIGKAEPVGLFVETFGTAKVDTEKIEAAIDEVFDLRPAAIIRDLDLLRPIYAQTAAYGHFGRELPDFTWERTDRVDALRKAAGL
>NZ_CP022310.1|WP_142196527.1|6557239_6558442_+|bifunctional-phosphopantothenoylcysteine-decarboxylase/phosphopantothenate--cysteine-ligase-CoaBC
MDKPKVVLGVSGGIAAYKACELLRRLTESGHDVRVVPTASALHFVGAATWSALSGHPVSTEVWDDVHEVPHVRIGQHADLVVVAPATADMLAKAAHGLADDLLTNTLLTARCPVVFAPAMHTEMWEHPATQENVATLRARGAVVIEPAVGRLTGVDTGKGRLPDPGEIFEVCRRVLARGVTEPDLRGRHVVVSAGGTREPLDPVRFLGNRSSGKQGYALARTAAARGARVTLIAANALLPDPAGVDVVQVGTAVELRQAVLAAAADADAVVMAAAVADFRPAVYATGKIKKKDGQEPEPVALVRNPDILAEISGDRVRAGQVIVGFAAETDDVLANGRAKLKRKGCDLLVVNEVGERKTFGSEENEAVVLGADGSETPVPHGPKEALAETVWDLVAERLG
>NZ_CP022310.1|WP_004933985.1|6556845_6557118_+|DNA-directed-RNA-polymerase-subunit-omega
MSSSISAPEGIINPPIDELLEATDSKYSLVIYAAKRARQINAYYSQLGEGLLEYVGPLVDTHVHEKPLSIALREINAGLLTSEAVEGPGQ
>NZ_CP022310.1|WP_142233487.1|6556189_6556783_+|guanylate-kinase
MAATPRGTSPVPPDVSPRLTVLSGPSGVGKSTVVAHMRKEHPEVWLSVSATTRKPRPGEQHGVHYFFVTDDEMDKLIANGELLEWAEFAGNRYGTPRAAVLEHLEAGVPVLLEIDLQGARQVRESMAEAQLVFLAPPSWEELVRRLTGRGTESAEVIERRLDAAKTELAAEPEFDTTLVNTSVEDVARELLALMNVV
>NZ_CP022310.1|WP_003977346.1|6555828_6556152_+|integration-host-factor
MALPPLTPEQRAAALEKAAAARRERAEVKNRLKHSGASLHEVIKQGQENDVIGKMKVSALLESLPGVGKVRAKQIMERLGISESRRVRGLGSNQIASLEREFGSTGS
>NZ_CP022310.1|WP_167530136.1|6554726_6555572_+|orotidine-5'-phosphate-decarboxylase
MSGLEPFGARLRRAMDERGPLCVGIDPHASLLAEWGLNDDVAGLERFSRTVVEAVADRVAVLKPQSAFFERFGSRGVAVLERTVQEAREAGALVVMDAKRGDIGSTMAAYAESFLHKDAPLFSDALTVSPYLGYGSLSPAVALARESGTGLFVLALTSNPEGGEVQHAVRADGRTVGATMLGHLALENAGEEPLGSFGAVVGATLGDLSSYDLDMGGPILAPGIGAQGATAADLPAVFGSAVRNVVPNVSRSVLRHGPDAVALRDAAERFAEEIRAAVTSA
>NZ_CP022310.1|WP_142233486.1|6553623_6554730_+|quinone-dependent-dihydroorotate-dehydrogenase
MYTILFTLLFRRMDPEQAHHLAFRWIRRVARVPVLRTFVAAVLAPRHEELRTEALGLRLHSPFGLAAGFDKNAVGIDGLAMLGFDHVEIGTVTGEPQPGNPRKRLFRLVADRALINRMGFNNEGSLAVAARLAARTPVFRTVVGVNIGKTKAVPESEAVADYVKSAERLAPYADYLVVNVSSPNTPGLRNLQAVDHLRPLLTAVREAADRTVTARRVPLLVKIAPDLADEDVDAVADLAVELGLDGIIATNTTIAREGLGLRSDPALVAETGGLSGAPLKERSLEVLRRLYARVGDRITLVGVGGIENAEDAWQRILAGATLVQGYSAFIYEGPFWGRAMHKGLAARLRTSPYATLADAVGADVRTTA
>NZ_CP022310.1|WP_142233485.1|6550264_6553573_+|carbamoyl-phosphate-synthase-large-subunit
MPKRTDIQSVLVIGSGPIVIGQAAEFDYSGTQACRVLKAEGLRVVLVNSNPATIMTDPEIADATYVEPITPEFVEKIIAKERPDALLPTLGGQTALNTAISLHENGVLEKYGVELIGANVQAIHKGEDRDLFKEVVEEVRKKIGHGESARSYICHSMDDVLKGVEELGGYPVVVRPSFTMGGAGSGFAHDEEELRRIAGQGLTLSPTTEVLLEESILGWKEYELELMRDKNDNVVVVCSIENFDPMGVHTGDSITVAPAMTLTDREYQVLRDVGIAIIREVGVDTGGCNIQFAVNPADGRVIVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDEIPNDITQETPASFEPTLDYVVVKAPRFAFEKFPSADSTLTTTMKSVGEAMAIGRNFTEAFQKALRSLEKKGSQFTFVGEPGDKRELLQASVRPTDGRINTVMQAIRAGATPEEVFEYTKIDPWFVDQLFLIKEIADELSEAPELTADLLAEAKRHGFSDQQIGEIRGLREDVVREVRHALGIRPVYKTVDTCAAEFAAKTPYFYSSYDEESEVAPREKPAVIILGSGPNRIGQGIEFDYSCVHASFALSDAGYETVMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEIVHAEQQAGPVAGVVVQLGGQTPLGLSQALKDNGVPIVGTSPEAIHAAEDRGAFGQVLKEAGLPAPKHGTATTFAEAKAIADEIGYPVLVRPSYVLGGRGMEIVYDETRLESYIAESTEISPSRPVLVDRFLDDAIEIDVDALYDGEELYLGGVMEHIEEAGIHSGDSACALPPITLGGFDIKRLRASTEAIARGVGVRGLINIQFALAGDILYVLEANPRASRTVPFTSKATAVPLAKAAARISLGATVAELRAEGLLPANGDGGELPLDAPISVKEAVMPWSRFRDIHGRGVDTVLGPEMRSTGEVMGIDSVFGTAYAKSQAGAYGPLPTKGRAFISVANRDKRSMIFPARELVAHGFELLATSGTAEVLKRNGINATVVRKHSEGTGPNGEKTIVQLIHDGEVDLIVNTPYGTGGRLDGYDIRTAAVARSVPCLTTVQALAAAVQGIDALHRGDVGVRSLQEHAQHLTAARD
>NZ_CP022310.1|WP_142233484.1|6549129_6550272_+|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MTTSTRGATKVPAVLVLEDGRIFRGRAYGAVGETFGEAVFSTGMTGYQETLTDPSYHRQVVVMTAPHVGNTGVNDEDAESQRIWVSGYVVRDPARVPSNWRSRRSLDDELAAQGVVGISGIDTRALTRHLRERGAMRVGIFSGDAVRDDAALLARVQEAPQMKGADLSAEVATTEPYVVPAIGEKKFTVAAVDLGIKGMTPQRMAERGIEVHVLPATATVDDVYAVNPDGVFFSNGPGDPATADHPVAVMRGVLERGTPLFGICFGNQILGRALGFGTFKLKYGHRGINQPVQDRTTGKVEVTAHNHGFAVDAPLDKVSDTPFGRAEVSHVCLNDNVVEGLQLLDRPAFSVQYHPEAAAGPHDAAYLFDRFVSLMEGQRA
>NZ_CP022310.1|WP_142233489.1|6562922_6563471_-|hypothetical-protein
MADHATHDAQARASLHLLVRDIERVRRQVDALRTLTAQLGNVYRPRRSGPSTGFVVYGRAPAPTVRLAQELRDSVETLVTAAVDFDRSLGFSWDAVGSALGVTKQAVHRRYGARRAAAQPPAPAEAERAAEASGSRPVNVGAGVSAVPTVPAARTMPTQPTAGSPSLREEPRPTALPAPRNG
>NZ_CP022310.1|WP_142196531.1|6563700_6564633_+|methionyl-tRNA-formyltransferase
MKLVFAGTPEVAVPALDALLAAGRHEVAAVVTRPDAPAGRGRRLVASPVAERAEEAGIEVLKPARPRDPEFLERLKEIAPDCCPVVAYGALLPKEALDIPARGWVNLHFSLLPAWRGAAPVQHAIMAGDEITGAATFLIEEGLDSGPVYGTVTEEIRPTDTSGDLLTRLAFAGAGLLAATMDGIEDGTLKAVPQPADGISLAPKVTVEDARVDWRTPALRVDRVVRGCTPAPGAWTTFRGERLKIVQAAPVPELTDLAPGQLSAGKNNVYVGTGSYAVELLWVQAQGKKPMRAADWARGVRIAPGETVGA
>NZ_CP022310.1|WP_142233490.1|6564708_6566127_+|rRNA-cytosine-C5-methyltransferase
MSDQPRRPRKPAKPYRRPQKDPVRILAFEALRAVDERDAYANLVLPPLLRKAREKGDFDARDAALATELVYGTLRRQGTYDAVVAACVDRPLREVDPPVLDVLSLGAHQLLGTRIPTHAAVSASVELARVVLGDGRAKFVNAVLRKVAQHDLDGWLERVAPPYDEDPEDHLAVVHSHPRWVVSALWDSLGGGRAGIEDLLRADNERPEVTLVARPGRATTAELLTEEAAVPGRWSPHAVRLTEGGEPGAIAAVAEGRAGVQDEGSQLVALALANAPVDGPDRLWLDGCAGPGGKAALLGALAAERGAVLLASEKQPHRAGLVARALAGNPGPYQVVAADGTRPPWRPGSFDRVLVDVPCTGLGALRRRPEARWRRRPEDLDGFAPLQRGLLRTALESVRVGGVVGYATCSPHLAETRAVVADLLKQFPDADLIDARPLLPGVPDLGEGPDVQLWPHLHGTDAMYLALIRRTG
>NZ_CP022310.1|WP_142196533.1|6566244_6566931_+|ribulose-phosphate-3-epimerase
MAVQINPSILSADFARLADEAKAVEGADWLHVDVMDNHFVPNLTLGVPVVESLARATDTPLDCHLMIEAPDRWAPQYVEAGAGSVTFHAEAATAPVRLAREIRAKGARASMALRPATPVEPYEDLLPELDMLLIMTVEPGFGGQAFLDIMLPKIRRTRELIKKHGLQLWLQVDGGVSASTIERCAEAGADVFVAGSAVYGADDPAEAVRALRYQAEAATGKASWACDH
>NZ_CP022310.1|WP_142196534.1|6567009_6568053_+|transcriptional-regulator
MNSSEEIAVSGMSAGRSAMRMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLETALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPAEAEETPDPENLGEVAADLLGELVNEGDVLGLAWGRSTIHMAAALDRLPPCTVVQLTGVYDAGTAERGSVEAVRRAAQVSGGDAHPIYAPMLLPDAATAEALRHQTGIARAFEYFDKVTVACVSIGSWEPGISTVHDMLSDEERAHYASLGVAAEMSAHLFDAEGRRVGRDLGERCITVKTDQLRRVPEVVAIAGGQRKGPAIDAVLRSGLVTSLVTDTSAADYLMTAGPAPRSALNRADPDGP
>NZ_CP022310.1|WP_142196535.1|6568093_6568480_+|ribonuclease-N
MPLRRTLVLRLLACLLVLLTGCSPAGEDTAAPAWAEGMPTVREADLPGEARDTLDLIDAGGPFPYERDGAVFGNFEGLLPRRQRGYYHEYTVRTPGSPDRGARRIVTGRGGETYYTDDHYASFTAVLR
>NZ_CP022310.1|WP_142196536.1|6568476_6568830_+|barstar-family-protein
MTYDPTGPLVVTVDLDGVTDKAGLMDRCARALELPDWFGRNWDALVDCLADHTVWPDGAVERGLLVVVRGWQAYATARSEEWATAREVFAEAADRTPSLTVALALGGSSEQASDQPG
>NZ_CP022310.1|WP_167530212.1|6568937_6570380_+|GuaB1-family-IMP-dehydrogenase-related-protein
MRFLNDIQPAYDLTYDDVFMVPSRSAVGSRQGVDLSSPDGTGTTIPLVVANMTAIAGRRMAETMARRGGLVVIPQDIPIEVVTEVVSWVKGRHLVLDTPIVLAPHQTVADALSLLPKRAHNAGVVVDDGHRPIGVVTDTDLSGVDRFTQLEEVMSKDLLLIDADMDPREAFHTLDGANRRYAPAVDKDGRLAGILTRKGALRATLYTPATDAAGRLRIAAAVGINGDVAGKARQLLDAGVDTLVIDTAHGHQESMINALKLVRDLDPQVPVVAGNVVAAAGVRDLIEAGADIVKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEARKYGKHVWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQHDANGRPYKESFGMASARAVRNRTSEESAYDRARKALFEEGISTSRMFLDPVRPGVEDLIDSIIAGVRSSCTYAGAGSLEEFAEKAVVGIQSAAGYAEGKPLHASWN
>NZ_CP022310.1|WP_142233492.1|6570702_6572181_+|amino-acid-permease
MLDQGAPPHNGSPAAPPSPGPGARLMRRKPVERLVAEGGQGEGGSLRRSLGLWQLTMISIGATLGTGIFVVLGEAVPKAGPAVTLSFVIAGLTALFSALSYAELAGTIPVSGSSYSYAYATMGELVAWVCGWCLVLEYGVSVAAVAVGWGEYLNELLDGTIGVTIPAALSAPPGDGGVFNLPALIVVLLAMAFLMGGARESARANTIMVVVKIGALVLFCAIGVQGFRSGNYENFMPLGMAGVSAAGATLFFSYIGFDAASTAGEEAKNAQRDLPRAILLSLVIITALYVLVAAVAVGAKPWRNFTDSEAALAQIMREVTGQTFWGTLLAFCAVIAIASVVLTVLYGQTRILFAMSRDGLVPKLFARVHPKTGTPRANTLIVSLFCGVLAAAVPLGQLADATSIGTLFAFALVNVAVVVLRRSRPDMPRTFRVPLSPVLPALGFAFCLWMMGSLSAITWVVFGVWMAVGLVVYFGYGHRRSRLAAPVPSEAK
>NZ_CP022310.1|WP_142196539.1|6572191_6572644_+|AsnC-family-transcriptional-regulator
MLNDLDERIVHALAEDARRSYADIGQMVGLSAPAVKRRVDRLRATGAITGFTVRVDPAALGWETEGFVEIYCRGNTSPETIQRGLERYQEVVAASTVTGDADAVAQVFASDMRHFERVLERIAGEPFVERTKSVLVLSPLLRRFSSGSPT

Crispr_ID: NZ_CP022310_20

• CRISPR_ID: NZ_CP022310_20
• CRISPR_location: 6947339-6947469
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_20

Consensus_repeat	Method
CCGTTCACGCCCCGTGCGCGCCGATGTCAGGCGTCGGCCGCC	CRISPRCasFinder

spacers of NZ_CP022310_20

>20.1|6947381|47|NZ_CP022310|CRISPRCasFinder
GGCGGCGAGCCGACCGGAGGACGGGCAGCCGGAACTGAACCGCGAGG

CRISPR arrays and Neighbor proteins around NZ_CP022310_20

CRISPR arrays

The CRISPR arrays of NZ_CP022310_20

>merge|NZ_CP022310|20|6947339-6947469|CRISPRCasFinder
CCGTTCACGCCCCGTGCGCGCCGATGTCAGGCGTCGGCCGCCGGCGGCGAGCCGACCGGAGGACGGGCAGCCGGAACTGAACCGCGAGGCCGTTCACGCCCCGTGCGCGCCGATGTCAGGCGTCGGCCGCC

>NZ_CP022310|20|17|6947339-6947469|CRISPRCasFinder
CCGTTCACGCCCCGTGCGCGCCGATGTCAGGCGTCGGCCGCC	GGCGGCGAGCCGACCGGAGGACGGGCAGCCGGAACTGAACCGCGAGG
CCGTTCACGCCCCGTGCGCGCCGATGTCAGGCGTCGGCCGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_161174606.1|6938207_6939089_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233643.1|6952810_6953482_-|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|239486
NZ_CP022310.1|WP_142233645.1|6954609_6955164_-|DUF5134-domain-containing-protein	unknown	unknown	gnl|CDD|375044
NZ_CP022310.1|WP_142196811.1|6939215_6940223_-|ATPase	unknown	unknown	gnl|CDD|225518
NZ_CP022310.1|WP_142233639.1|6942225_6944319_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_CP022310.1|WP_142196815.1|6944550_6945354_-|pectate-lyase	unknown	unknown	gnl|CDD|367395
NZ_CP022310.1|WP_142196809.1|6936430_6937918_+|FUSC-family-protein	unknown	unknown	gnl|CDD|379231
NZ_CP022310.1|WP_142196819.1|6949037_6949502_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142196812.1|6940219_6940897_-|uracil-DNA-glycosylase	unknown	unknown	gnl|CDD|235376
NZ_CP022310.1|WP_142196808.1|6935745_6936225_-|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_CP022310.1|WP_142233646.1|6955333_6957073_+|FUSC-family-protein	unknown	unknown	gnl|CDD|379231
NZ_CP022310.1|WP_142233644.1|6953578_6954514_-|M48-family-metalloprotease	unknown	unknown	gnl|CDD|320685
NZ_CP022310.1|WP_142233647.1|6957069_6957651_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP022310.1|WP_142196817.1|6946838_6947198_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197713
NZ_CP022310.1|WP_142233642.1|6951874_6952591_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP022310.1|WP_142196820.1|6949529_6950192_-|DUF305-domain-containing-protein	unknown	unknown	gnl|CDD|367619
NZ_CP022310.1|WP_142233648.1|6958127_6958892_-|VOC-family-protein	unknown	unknown	gnl|CDD|319911
NZ_CP022310.1|WP_142196813.1|6940970_6942125_-|exo-alpha-sialidase	unknown	unknown	gnl|CDD|374209
NZ_CP022310.1|WP_142196821.1|6950384_6951887_+|hypothetical-protein	unknown	unknown	gnl|CDD|293789
NZ_CP022310.1|WP_142233640.1|6945633_6946713_-|NADH:flavin-oxidoreductase/NADH-oxidase	unknown	unknown	gnl|CDD|239242

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233643.1|6952810_6953482_-|phosphatase-PAP2-family-protein	gnl|CDD|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.4409e-34
NZ_CP022310.1|WP_142233645.1|6954609_6955164_-|DUF5134-domain-containing-protein	gnl|CDD|375044	pfam17197, DUF5134, Domain of unknown function (DUF5134). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of the tetramic-acid antibiotic streptolydigin, which inhibits bacterial RNA polymerase (RNAP).	2.1914e-12
NZ_CP022310.1|WP_142196811.1|6939215_6940223_-|ATPase	gnl|CDD|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	7.42647e-35
NZ_CP022310.1|WP_142233639.1|6942225_6944319_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	0.000239708
NZ_CP022310.1|WP_142196815.1|6944550_6945354_-|pectate-lyase	gnl|CDD|367395	pfam03211, Pectate_lyase, Pectate lyase.	2.61512e-93
NZ_CP022310.1|WP_142196809.1|6936430_6937918_+|FUSC-family-protein	gnl|CDD|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	1.44647e-12
NZ_CP022310.1|WP_142196820.1|6949529_6950192_-|DUF305-domain-containing-protein	gnl|CDD|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	9.66617e-52
NZ_CP022310.1|WP_142196808.1|6935745_6936225_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.06191e-31
NZ_CP022310.1|WP_142233646.1|6955333_6957073_+|FUSC-family-protein	gnl|CDD|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	1.43221e-22
NZ_CP022310.1|WP_142233644.1|6953578_6954514_-|M48-family-metalloprotease	gnl|CDD|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	2.80055e-29
NZ_CP022310.1|WP_142233647.1|6957069_6957651_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.01157e-20
NZ_CP022310.1|WP_142196817.1|6946838_6947198_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	4.58561e-08
NZ_CP022310.1|WP_142233642.1|6951874_6952591_-|TetR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.99504e-12
NZ_CP022310.1|WP_142196812.1|6940219_6940897_-|uracil-DNA-glycosylase	gnl|CDD|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	4.67972e-122
NZ_CP022310.1|WP_142233648.1|6958127_6958892_-|VOC-family-protein	gnl|CDD|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	1.2113e-29
NZ_CP022310.1|WP_142196813.1|6940970_6942125_-|exo-alpha-sialidase	gnl|CDD|374209	pfam15902, Sortilin-Vps10, Sortilin, neurotensin receptor 3,. Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.	2.9537e-06
NZ_CP022310.1|WP_142196821.1|6950384_6951887_+|hypothetical-protein	gnl|CDD|293789	sd00042, LVIVD, LVIVD repeat. LVIVD repeats are mainly found in bacterial and archaeal cell surface proteins, many of them hypothetical. Structurally, LVIVD repeats have been predicted to form a beta-propeller, with each repeat forming one four-stranded anti-parallel beta-sheet blade.	3.31908e-16
NZ_CP022310.1|WP_142233640.1|6945633_6946713_-|NADH:flavin-oxidoreductase/NADH-oxidase	gnl|CDD|239242	cd02932, OYE_YqiM_FMN, Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing agent. The YqjM enzyme exists as a homotetramer that is assembled as a dimer of catalytically dependent dimers, while other OYE members exist only as monomers or dimers. Moreover, the protein displays a shared active site architecture where an arginine finger at the COOH terminus of one monomer extends into the active site of the adjacent monomer and is directly involved in substrate recognition. Another remarkable difference in the binding of the ligand in YqjM is represented by the contribution of the NH2-terminal tyrosine instead of a COOH-terminal tyrosine in OYE and its homologs.	0

Protein sequences

>NZ_CP022310.1|WP_142196817.1|6946838_6947198_+|helix-turn-helix-domain-containing-protein
MTTAAPAPSSRDLPHPAREEIRLEGVLHALSDPVRLRIVRELADEEVRLSCSHFDLPVTKSTTTHHFRVLRESGVIRQTYEGTAKMNGLRRDDLDDLFPGLLDCLLTAAARQADRHRGA
>NZ_CP022310.1|WP_142233640.1|6945633_6946713_-|NADH:flavin-oxidoreductase/NADH-oxidase
MSTLFEPYTLRDVTIPNRVWMPPMCQYSAAPDGPEAGAPVDWHFAHYAARAAGGTGLIVVEATAVSPEGRISPYDLGIWNDTQVEAFRRITRFLVSQGTVPAIQLAHAGRKASTDRPWKGGASVGPEAHGWQPVAPSPLAFDERHPTPDELSVERIHEIVGEFRAAARRALAAGFEIAEIHGAHGYLINEFLSPHSNHRTDAYGGSYENRTRFALEVVDAVREEWPDDKPLFFRISATDWLDGSGWTPDDTVRFAGELHAHGIDLLDVSTGGNASGVRIPTGPGYQVPFAARVRNETPMPVAAVGLITDAEQAEKIVANGEADAVLLGRELLRNPSWARHAARELGGEVHVPDQYHRSV
>NZ_CP022310.1|WP_142196815.1|6944550_6945354_-|pectate-lyase
MTSATRPRARRRALTGALATLGLSVGMIMTTGASPANAATWPTPNGSEGVSSTISVSGTKDYGMKRLYGTGDLGSGGQDEDQGPILQLADGAVLKNVILGAPAADGIHCQGSCTLQNVWWEDVGEDAATFKGKSSGAVYTVSGGGAKEASDKVFQFNGAGTLNVSNFAVKNFGTFVRSCGNCSTQYKRTINLNTIEVTYKGSRIAGINTNYGDSATLRNITIIGDSSRKIVPCQKYIGNDDGDEPDSNGSGPDGTYCKYSSSDITYR
>NZ_CP022310.1|WP_142233639.1|6942225_6944319_-|HEAT-repeat-domain-containing-protein
MFTGIDEVDWASMRHAYGSAEDVPRLLRGLASPDAAERETALDGMYGAVHHQGDVYDSTLACVPFLFALAVREEVPDRAGIVELLVSIGGADEEAESEAEADEEAESEAGTDGVPDAAVGGEADGHGPHAMARTAVRVGAGVFALLLGDADPAVRRAAPGALVRFLDQPERVLGLLRERITVERDDRVLLALTESLGRFARRHPHLAAGAVDLLVERSAPPHGPGLRLAALGQLAGCAPERLPADPVPVVLRLLDERAALRPADPEEPGGPDPDTLVGRLRRLRPSVEEGSRLLRTLHTALDDRVADRIALLSGQLGRPDPVDRCNAVWMSAGLFRTWRADYTEPVGLVGAQLTGGDDRLRDAAVAVLEDLFELALPAAGHLHALLTDRPELRVHTWERGVPTLGRPLRALARTGDPRAVGLLAEVLAGPVVPDDLGHVVPALGRAAAPLAPALRQHLAGLPLDADDLYERAGSTLRALAAIGDAEAVPVVLRMPAGMPAGLRLRDSLVAAAFRALGAAGAGAREAIPALRAALRGGQGVVAAEALWAVEGDPEAVLPVLLGELDAGSGGSRRAAAEVLGRLGPAARAALPGLRRLTQSGDLWERTAAAHALWRVAGEPETAADVLRAAWAESPYTRVPTADLAARLGPAAAPLHDLLRAELAAPRRHRAGPGGHGSHDVHEDERLLRSCRRALAGG
>NZ_CP022310.1|WP_142196813.1|6940970_6942125_-|exo-alpha-sialidase
MVGCRLARVRNEDVDEDVAEVIGMTEVLLAVGTRKGLFIGRRRGGTWEFDESPYFNAQAVYSVAVDTRGARPRLLVGGDSAHWGPSVFHSDDLGRTWTEPARPAVKFPKDTGASLERVWQLHPAAAEPDVVYAGTEPAALYRSEDRGESFELVRPLWEHPTRSRWMPGGGGEGLHTVLTDARDPRAVTVAVSTAGVFRTLDGGASWAPSNSGVSAVFLPDPDPEFGQCVHKVARDAADPDRLYLQNHWGVYRSDDAGGHWTDIGEGLPSTFGFTVVTHPRRGDTAYVFPINADSDRVPAGRRCRVYRTADAGRSWEPLAAGLPQEDHYGTVLRDAMCHDGVDPAGLYFGNRNGEVYASADDGDSWRQLASHLPDVLCVRAAVVG
>NZ_CP022310.1|WP_142196812.1|6940219_6940897_-|uracil-DNA-glycosylase
MAPQPLNEIVEAGWAQALEPVAGRISAMGDFLRAEIAAGRTYLPAGANVLRAFQQPFDEVRVLIVGQDPYPTPGHAVGLSFSVAPEVRPLPGSLINIFRELTTDLGLPQPSNGDLTPWTEQGVLLLNRALTTAPRKPGAHRGKGWEEVTEQAIRALAGRGKPLVSILWGRDARNCRPLLGDLPAVESAHPSPMSADRGFFGSRPFSRANDLLIRQGGQPVDWRLP
>NZ_CP022310.1|WP_142196811.1|6939215_6940223_-|ATPase
MTGTGYLAVDSGGSGVRFVVGAAGRGPLARGALEEPVRTGPRGLDPDHLMEQLVPMARSLCAEAGVGRLATAVVGAAGLASLGDALRAELPGMLRSELGVHRVALAADAVTAYVGALGPRPGAVIAAGTGLIAVGTDLTGWRRADGWGHLLGDCGGGAWIGRAGLEAAMRAHDGRAGGSAPLLASAEDLFGPAAGLPGRLYPRTDRPAVLASFAPRVGACAAGGDPVAVRILRAAARHMADSAAAVCPAAGEPVVGLTGGLFELGAVLLAPLDEELAERLPRARRVMAEGDPLHGAVRVAEDLARDSLTLPCDEKMLCVTSPAGEAVTSATDART
>NZ_CP022310.1|WP_161174606.1|6938207_6939089_-|hypothetical-protein
MPRPRQPGRHRRPEPLVAPEGAPALVLAVPGTPSSATRSLADEVVSIARSELPGLDARIGYVDGDDEEFPTLQSVLSHAAEERTARFEQARAAGMDVKEPDGPVAVVVPLLAGPDSALLRQVRQAVMDSRVAAELTDVLGPHPLLAEALHVRLSEAGLARADRARLFTVATAADGIILASVGGDEAVQAAGITGMLLAARLAVPVMAAALDQEGSIASVAEQLRSAGSQQLALAPYLIGPEIDASLIEEAAKEADCSASEALGPYPAIGKLALAKYTTALGIAPQQAQGTPAR
>NZ_CP022310.1|WP_142196809.1|6936430_6937918_+|FUSC-family-protein
MLKRVFMAPDPGRTRLRFAARAVLGISVAVVVCGLAGHTLTGAVTGGLAALLALFTVTDATVRAQALTTALLPAVGLPVLAVAAVLHDHPVARDLVFLAVVGLGVYARRWGPRGHSLGVFAFMTYFVAQFLHTRTHQLPELYASVVLSVLAAATVRFGIWCYERRLPPAVVPAPPGGTGLARVTTRQAIQATAGAGFALVVGQLVSGQRWYWAVGATWWVFVNTTSRGETLVRGFRRVLGTVIGIGIALFVAVPAHGDGPLTALVVALSVFGIFYTAAVSYTWMMLWVTVLAAMLYGLLGVLTPGLLALRLVETGVGALGAALAVAFVLPVTTHSVTDAWIQRALRCVHACTAETAARLAGKADADPTPLVAELEQLLARVRLSVAPLVHPLHPALGRKRRARRVLDLLDDCAREIRGLVAVAADPEASHDDRLAAACRRVEVAVEALTEGRDIAVHTAPAATEPALAHLHGLERALAELAAPLRARSGSPLVGA
>NZ_CP022310.1|WP_142196808.1|6935745_6936225_-|winged-helix-turn-helix-transcriptional-regulator
MTVDELDTRILRLLLERPRTSVREYARILGVARGTLQARLDRLERDGVITGTGPALSPAALGHPVLAFVHIEVTQGHLDEVGDALAAVPEIVEAFSITGGGDLLTRVVARDAGHLEDVIQQLISLPGVVRTRTEVALRERVPHRLLPLVESVGRSAARK
>NZ_CP022310.1|WP_142196819.1|6949037_6949502_+|hypothetical-protein
MSVWPAWEVREGDRATRWLHVRLAFGDGARIDALATVSEGWVCVEDVRAQPALALEDLAVFADWIEGPLARACEAGAGPEPGDGAGPGAHRDGADGPRAPEWRHVARAYRTAQERGADPVLAVMDETGYSRRGALRLIGRTRDAGLLSPRHARR
>NZ_CP022310.1|WP_142196820.1|6949529_6950192_-|DUF305-domain-containing-protein
MHYRRPSRVSVVAAGLTALAVLGLVGCDSDTDAAESAASSGPSVIAPGEPGEANRTLSAEEAEQRRAEDDSPNSADVDYARMMIEHHAQALEMTDLVPDRAESPKIVKLAERIAAAQDPEIKAMKGWLKSHGKAERDHGHGHDHATMPGMATQAQLKQLRAADGKAFDQLFLTLMITHHQGAITMATEVKGEGNNIRIEEMADDVVAQQTSEINRMRNLL
>NZ_CP022310.1|WP_142196821.1|6950384_6951887_+|hypothetical-protein
MILLSVSRTRRRRLGVAAAAGGLLAALLTAAPAAAIPDPGDPPADRKEVSRSDQAEAREAIESGEIPGQDEVVHSDNIRHVAHVPKDALPGTNSDLAFQGRYAFAGNYDGFRIFDISNPKAPKTVAQVLCPGSQNDISVSGDLLFLSTDSSRSDSSCNSTTQPATEKSSWEGMKVFDISDKSNPRYVAAVETACGSHTHTLVPERKNVYVYVSSYSPNAAYPDCQPPHDGISVIKVPREAPEKAALVGFPVLFPGEGADGGGNPGAPTNPGVSKTTGCHDITVLPSKDLAAGACMGDGILFSIKDPEHPKVIDRVQDNVNFAFWHSATFNQKANKVVFTDELGGGGAATCNAEIGPNRGADGIYDVVGRGDQRELVFRSYFKIPRHQADTENCVAHNGSLIPVKGRDLMVQAWYQGGVSVWDFTNSSKPKEIAYFERGPLSTDSIVTGGSWSAYYYNGYIYSNDMAKGFDVLQIDDRRTDPARWVTMRELNVQTQPDYFG
>NZ_CP022310.1|WP_142233642.1|6951874_6952591_-|TetR-family-transcriptional-regulator
MSPRSALVNEELRRRSKERLLQAAVELVSEHGYDATTLGDIADRAGSARGLVSYYFPGKRHLVQSAVHRLMHRTLEEALEREPRTEDGRERMARAIDAILGLARDRPVLMRQHMAGLLQAEGFLPCPEQRRLAELLSDTVARHGSRDVEADYPMLRALLMGAVYAALMPGAPMPVPALREELFKRYGLDWELGVPPDTEASGGTCGTDGTDLTRFFATGPAADCPAPAPRPEPDAQPK
>NZ_CP022310.1|WP_142233643.1|6952810_6953482_-|phosphatase-PAP2-family-protein
MHTSHVDSPPSPPQHRPATLPTVVPALCSALLLALVAVEWRPLLDLDGDISRTTHRWAVAEPGLTQTARILTDWVWDPWTMRVLVAVAAALLAWRYAARWTAAWLVVTVAVGTAVQQGLKAALDRARPVWPDPVDSAHYAAFPSGHAMTATVVCGLLLWLLHRHGVSAGVRRAALVLAVVSVAGVGLTRVWLGVHWPTDVLGGWLLGATVVAAAVAVHKRLRP
>NZ_CP022310.1|WP_142233644.1|6953578_6954514_-|M48-family-metalloprotease
MILPAVLLLLGVLTAVVGPRLLARADWPDREPVVALWTWQCVIAAVLLCCALSMTFSAAAAWRAVGGHVFAAAPRAVVEAYALGTAGLWAGTTAVALACGGLWSVAMLVREVVRARARRRARRAELRLRAPLLPGEEPGADRLVVLEGERPDAWWLPGTPPQLVVTTAALRRLKGRQLDAVLAHERGHAQARHAWLLHCSAALAGGFPQVPVFAAFRREMHRLVELAADDMASRRFGRLTTALALVELNEHRGVFGPCPTPQARVPARVHRLLTPPDRLTAGRRLRLTAVASLVPVVPVLVAFVPGLRALG
>NZ_CP022310.1|WP_142233645.1|6954609_6955164_-|DUF5134-domain-containing-protein
MHGPASSGWLLVALCAATGTYCLLRMRSRLEEQRRAAGGEALMGFGMAAMAVPAAVFTPPGWAWAAGAVVFGAAGLHALRTVRAGACHLHHLIGTGAMVHMALTMTTAPAHGHAHGPGGSGTPLLTGALLLYFVAYVLVTGVRLVPAAAAEGSGRDLGWRDRPELARACRLSMALAMVAMLPAM
>NZ_CP022310.1|WP_142233646.1|6955333_6957073_+|FUSC-family-protein
MSSATPVPSVRTARRLPLAGALRLGRPSDIWFKPALSVVASVAPPGLLLVALGRLDLALYTMAGSLCALYAHNRPYAARARALAGVVLGMLGGLAVALVAASLTGNAVVLVTVGAVLAAVQKALCDATRIGPPGNVVLTFVSSASLFAPQTLGQVPGHLALAAAAGAWAWLVGMAPALIRPHGPERRATAHALDAAAAYAATAAARTGPGAADDGLTGPGTDDGNTGARAAGYAAVQSAWQSLLSTGNRPSDGRRALDRLVVRAEVALAAPAEADPERLRAWARTLRGTGPVPAVDDPRTDASELLGPAAERATPRRTLWGVLAPLTPLAVRTALGCALAGYASLALGIGRPYWALVTAAALYQANLTLTWSRAVQRVVGNLAGVLLFAAVAPVAHLGPLALVLCCLAFSFGAEALISRNYWLGSICVTPLALLVTEFAGPQRTGALVTERAVDTLVGALVGFVAALAVTNRRAGDRVARCLTAVDRAREAAARALADPQAAPAVLEAARRDLAAALVDLRAAADAASGEWWQRALPQERVVLAEQSGHRTLAATVRRQGLLPTSPGTGTDTDTEDVRP
>NZ_CP022310.1|WP_142233647.1|6957069_6957651_+|MarR-family-transcriptional-regulator
MTATEGPSATGTGEPSSPGGGPAGHARGDTVAAVVQQWRAVHPGLDTGPMEVIGRINRCAALLQQAEDAPLRRAGLTRPEFDLLGALRRTGHELTPSELARETFSSGAAVTKRLKQLTERGLVERRGDTRDRRVAHVRLTDAGRELVDGILPAQLAYETAALSGLDGPELGELAALLGTLLGQLEGRLGALRA
>NZ_CP022310.1|WP_142233648.1|6958127_6958892_-|VOC-family-protein
MRLSAPVRGGPCWAELGTSDPESAQRFYTRLFGWRHETDPRAEAEGYTVAHLGDAAVAAVTPLYQEAQPVAWNVSFAVADADAALGQVEAAGGRTLAGPTDVFDLGRFAVAADPGGAVFQLWQAGSFPGAGVFNVPGALGWVELLTRAPQQAVAFYTTVFGWSVTPSRRYPQWGLDGADFGGMVTMDDKFPHEVPSHWLPYFAVADVDDAAATATRARGTVLMEPVSPPEGPRIAVLRDPQGAMFGVHRAADEA

Crispr_ID: NZ_CP022310_21

• CRISPR_ID: NZ_CP022310_21
• CRISPR_location: 6978777-6978950
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP022310_21

Consensus_repeat	Method
GCCGGGGCACATGTGCGGGTGCCGCAC	CRISPRCasFinder

spacers of NZ_CP022310_21

>21.1|6978804|46|NZ_CP022310|CRISPRCasFinder
TGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCT
>21.2|6978877|47|NZ_CP022310|CRISPRCasFinder
CGTCGCCCACCGTCGGGGCACATGTGGGTGCCACACCGTCGCCCGCT

CRISPR arrays and Neighbor proteins around NZ_CP022310_21

CRISPR arrays

The CRISPR arrays of NZ_CP022310_21

>merge|NZ_CP022310|21|6978777-6978950|CRISPRCasFinder
GATGGAGCACATGTATGGGTGCCACACTGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCTACTGGGACACGTATGTGGGCGCCGCAGCGTCGCCCACCGTCGGGGCACATGTGGGTGCCACACCGTCGCCCGCTGCTGGGGCACATGTGTGGGTGCCGCAC

>NZ_CP022310|21|18|6978777-6978950|CRISPRCasFinder
GATGGAGCACATGTATGGGTGCCACAC	TGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCTGCCTGCT
ACTGGGACACGTATGTGGGCGCCGCAG	CGTCGCCCACCGTCGGGGCACATGTGGGTGCCACACCGTCGCCCGCT
GCTGGGGCACATGTGTGGGTGCCGCAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142233663.1|6983174_6984413_+|geranylgeranyl-reductase-family-protein	unknown	unknown	gnl|CDD|273936
NZ_CP022310.1|WP_167530141.1|6976329_6977406_-|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224525
NZ_CP022310.1|WP_142196843.1|6971239_6972202_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl|CDD|224936
NZ_CP022310.1|WP_142233662.1|6981618_6982980_-|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl|CDD|236127
NZ_CP022310.1|WP_142196859.1|6987989_6988868_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187613
NZ_CP022310.1|WP_142233657.1|6972372_6973677_+|aldolase	unknown	unknown	gnl|CDD|367449
NZ_CP022310.1|WP_142196855.1|6984679_6985972_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP022310.1|WP_142233658.1|6973769_6974267_+|DUF2975-domain-containing-protein	unknown	unknown	gnl|CDD|378586
NZ_CP022310.1|WP_142233661.1|6979506_6980547_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|239217
NZ_CP022310.1|WP_142196852.1|6980790_6981543_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293807
NZ_CP022310.1|WP_142233664.1|6987173_6987920_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl|CDD|274422
NZ_CP022310.1|WP_142196857.1|6986762_6987155_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP022310.1|WP_142196841.1|6969661_6970171_+|flavin-reductase-family-protein	unknown	unknown	gnl|CDD|214900
NZ_CP022310.1|WP_142196846.1|6974266_6974506_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|226181
NZ_CP022310.1|WP_142196850.1|6979171_6979363_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233659.1|6974556_6976272_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP022310.1|WP_142196849.1|6977619_6978573_+|ROK-family-protein	unknown	unknown	gnl|CDD|224851
NZ_CP022310.1|WP_142233656.1|6970389_6971178_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl|CDD|238847
NZ_CP022310.1|WP_142196856.1|6985968_6986634_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_CP022310.1|WP_142233655.1|6969108_6969444_+|thioredoxin-family-protein	unknown	unknown	gnl|CDD|239245

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233663.1|6983174_6984413_+|geranylgeranyl-reductase-family-protein	gnl|CDD|273936	TIGR02032, Uncharacterized_protein_MJ1520, geranylgeranyl reductase family. This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	4.63539e-96
NZ_CP022310.1|WP_167530141.1|6976329_6977406_-|substrate-binding-domain-containing-protein	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.11212e-104
NZ_CP022310.1|WP_142196843.1|6971239_6972202_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl|CDD|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	4.32663e-105
NZ_CP022310.1|WP_142233662.1|6981618_6982980_-|M20/M25/M40-family-metallo-hydrolase	gnl|CDD|236127	PRK07907, PRK07907, hypothetical protein; Provisional.	0
NZ_CP022310.1|WP_142196859.1|6987989_6988868_-|SDR-family-oxidoreductase	gnl|CDD|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.03257e-151
NZ_CP022310.1|WP_142233657.1|6972372_6973677_+|aldolase	gnl|CDD|367449	pfam03328, HpcH_HpaI, HpcH/HpaI aldolase/citrate lyase family. This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.	0.0067446
NZ_CP022310.1|WP_142196855.1|6984679_6985972_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.66424e-60
NZ_CP022310.1|WP_142233658.1|6973769_6974267_+|DUF2975-domain-containing-protein	gnl|CDD|378586	pfam11188, DUF2975, Protein of unknown function (DUF2975). This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	5.46398e-18
NZ_CP022310.1|WP_142233661.1|6979506_6980547_+|NUDIX-domain-containing-protein	gnl|CDD|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	1.7323e-16
NZ_CP022310.1|WP_142196852.1|6980790_6981543_-|MBL-fold-metallo-hydrolase	gnl|CDD|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.62555e-60
NZ_CP022310.1|WP_142233664.1|6987173_6987920_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl|CDD|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	1.61553e-14
NZ_CP022310.1|WP_142196857.1|6986762_6987155_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.3367e-21
NZ_CP022310.1|WP_142196841.1|6969661_6970171_+|flavin-reductase-family-protein	gnl|CDD|214900	smart00903, Flavin_Reduct, Flavin reductase like domain. This entry represents the FMN-binding domain found in NAD(P)H-flavin oxidoreductases (flavin reductases), a class of enzymes capable of producing reduced flavin for bacterial bioluminescence and other biological processes. This domain is also found in various other oxidoreductase and monooxygenase enzymes... This domain consists of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. The flavin reductases have a different dimerisation mode than that found in the PNP oxidase-like family, which also carries an FMN-binding domain with a similar topology.	1.0357e-45
NZ_CP022310.1|WP_142196846.1|6974266_6974506_+|helix-turn-helix-domain-containing-protein	gnl|CDD|226181	COG3655, COG3655, Predicted transcriptional regulator [Transcription].	4.38187e-31
NZ_CP022310.1|WP_142233659.1|6974556_6976272_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.15628e-103
NZ_CP022310.1|WP_142196849.1|6977619_6978573_+|ROK-family-protein	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.14579e-64
NZ_CP022310.1|WP_142233656.1|6970389_6971178_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl|CDD|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	4.17504e-79
NZ_CP022310.1|WP_142196856.1|6985968_6986634_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.08981e-67
NZ_CP022310.1|WP_142233655.1|6969108_6969444_+|thioredoxin-family-protein	gnl|CDD|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	3.58357e-12

Protein sequences

>NZ_CP022310.1|WP_142196849.1|6977619_6978573_+|ROK-family-protein
MHTDLVAALDIGGTKIAGALVDRQGRILDRAQRPTPAQEDGDTVMGAVDAVLGALSASPLWQRVGAVGIGSAGPVDASAGTVSPVNVPGWRDYPLVARVRAATGGLPVELIGDGVAITAAEHWQGAARGHDNALCMVVSTGVGGGLVLGGRLHPGPTGNAGHIGHISVDLDGDRCPCGTRGCVERIASGPNIARRALDNGWRPGPDGDTSAAAVAAAARAGDPVAVASFERAARALAAGIAATATLVEIDIAVIGGGVGKAGEVLFAPLRRALTEYATLSFVRRLAVAPAQMGTDAGLVGAAAAALARSEDPAVAGV
>NZ_CP022310.1|WP_167530141.1|6976329_6977406_-|substrate-binding-domain-containing-protein
MADRTGQRTVPETTRRTDRLPGNRYGNRPTMKDVAARAGVGLKTVSRVVNGEPGVTPETERRVQEAIEALGFRRNDSARVLRKGRTASIGLVLEDLADPFYGPLSRAVEEVARAHGALLINGSSAEDADREQELVLALCARRVDGLVVIPAGDDHRYLEPEVKAGVATVFVDRPAGHIEADVVVSDNFGGARDGVRHLIGHGHRRIGFIGDMPRIHTAAERLRGYRTAMEDAGIPVADSWMSLGATTPERVRRAAEEMLSGPEPVTAIFTGNNRVTVTVIRVLAGHARRVALVGFDDIELADLLEPGLTVVAQDAAALGRTAAERLFRQLDGTLLTPERIEIPTRLIARGSGELPPAD
>NZ_CP022310.1|WP_142233659.1|6974556_6976272_+|protein-kinase
MTTGEYGQPDGAGRLLAGRYRITAQLGRGGMGVVWKAVDEVLGREVAVKELRTYTDAAGPELADLGLRMQREARAAARVRHPGVIAVHDIAEVDGRPLIVMELIDGPSLDDVLRDRGTLDPVEAARVGAEVMDALAAAHRAGVLHRDVKPGNILLDRSGRIVLTDFGIATMEDPGDGSATHLTRSGEIVGSLDYLAPERAQGAVPGPASDVWALGATLYAAVEGASPFRRTSTFSTLTAIVTEPLPESRRAGPLAPVLGRLMDKRPESRPEAAEAHALLAAVAAGVDTPTTTLRRPVPPPGRTETELGVPAVPPGFGPPQRPEQSGAGLGSAGPDAHPAPDAASAPTGPMSTRPRSRRKGRALLAALAVTAVLAGAGVAVAVLDSDGTRTDADGTRTDTPAAPTSSGDTDAGRRMSPAPGTDDGGAPSEKAGGKQDADDTPGDGRTTPPARKTPDSGTSGEDGDGAGSVPDGGATSETPACHPVGDGTYNCQVWRTATSYTASGTEAGVLNAGTNYFYCQQNLGRRETHGEWTNVWWARTDDDSGNTGVWVSDVYIQGGSNDAPVPGLPNC
>NZ_CP022310.1|WP_142196846.1|6974266_6974506_+|helix-turn-helix-domain-containing-protein
MPIAVDIDVMLAKRKMSVGELAERVGITPANLAVLKNGRAKAVRFTTLAALCEVLDCQPGDLLRWEPDDAPPGPVTDAP
>NZ_CP022310.1|WP_142233658.1|6973769_6974267_+|DUF2975-domain-containing-protein
MGQLTVLALRAVIVALLAGSLAVQGVMVPLLARDLEGLDAAHSSLRVPILLVVVLVVLAAQTVLVCVWRLVTMVRRGTVFSHAAFRYVHIVIGAFVAAALLVFALGTLLAPGEAVAPGVVLLLGGAGLAALGIALVVLVLRMLLAQAVARDAEASRMQDELAGVV
>NZ_CP022310.1|WP_142233657.1|6972372_6973677_+|aldolase
MGQGQQERVTTSLAGAVAEEIGASLAPVDAELERRYPGDPGTRQPVHTVYVPGDAFTADTLRDWGDRALAALDEHAPDAAAFAAALGLDETLADDVYARVRAKLEREPVEDLRVDFEDGYGSRPDAEEDEAAARAARLIAAAYADGTAAPYMGIRMKCMEAAVRDRGIRTLDIFLTGLLEAGALPDGLVLTLPKVTYAEQVTAMARLLDAFEKTRGLEPGRIGFEIQIETSQSILATDGTATVARMIQAAEGRATGLHYGTFDYSACLGVSAAHQASDHPAADHAKAVMQVAAAGTGVRVCDGSTNVLPVGPTEKVHDAWRLHYGLTRRALARAYYQGWDMHPGHLPTRYAAVFAFYREGFERAAARLARYVDRAGGDVMDEPATAKALAGYLLRGLDCGALDPAEVARQTGLTRADLEGFASPRRGDLTATAR
>NZ_CP022310.1|WP_142196843.1|6971239_6972202_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MAEVLVYVDHVDGAVRKPTLELLTLARRIGEPVAVALGNGAGDTAATLAEHGAVKVLTHEAAEYADYLVVPKVDALQAAHEAVSPAAVLVPSSAEGKEIAARLALRLGSGIITDAVDLEAGDEGPVATQSVFAASYTTKSRVSKGTPVITVKPNSAAVEAAPAAGAVEALSVTFSAQATGTKVTGRTPRESTGRPELTEAAIVVSGGRGVNGAENFAIIEALADSLGAAVGASRAAVDAGWYPHTNQVGQTGKSVSPQLYIASGISGAIQHRAGMQTSKTIVAVNKDAEAPIFELVDYGVVGDLFDVVPQLTEEIKARKG
>NZ_CP022310.1|WP_142233656.1|6970389_6971178_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MSLRIVVTVKYVPDATGDRHFADDLTVDRDDVDGLLSELDEYAVEQALQISENSDDDVEITVLTVGPEDAKDALRKALSMGADKAIHVEDDDLHGTDAIGTSLVLAKAIEKAGYDLVISGMASTDGTMGVVPALLAERLGVPQVTLLSEVSVEDGTVKGRRDGDAASEQLEASLPAVVSVTDQSGEARYPSFKGIMAAKKKPVESWDLADLDLEAEEVGLEGSYTTVDAATERPARTAGTIVKDEGEGGKQLAEFLASQKFI
>NZ_CP022310.1|WP_142196841.1|6969661_6970171_+|flavin-reductase-family-protein
MTATSDLGTARLASPELLRSVFRKHAAGVAVITARGEAGPVGFTATSLASVSAEPPMLSFAVGTHSSTWPAIAAGDHVGVHVLGEHQRELAATFARSGADRFGPGTAWREGPEGVPVLDGVPAWTVCKVVARVPAGDHRIVVAELLAGDPTGHGRPLVYHQGRFSGLRD
>NZ_CP022310.1|WP_142233655.1|6969108_6969444_+|thioredoxin-family-protein
MRGHEGEVSAAGGAWADLGVPLGERATLVQFSTAFCAPCRATRRVLGEVAALVPGVAHVEIDAEARLDLVRRLDVVKTPTVLVLDAAGRIVRRATGQPRKADVIAALGEAV
>NZ_CP022310.1|WP_142196850.1|6979171_6979363_+|hypothetical-protein
MKKRSMLAIASLATGFVVAAITPSHAVGESIGGVSVDDTLDTLDRTVAEDNTLDLDVDRDDRD
>NZ_CP022310.1|WP_142233661.1|6979506_6980547_+|NUDIX-domain-containing-protein
MIVWINGAFGAGKTTTARELIELIPNSTLFDPEVIGGALERLLPPKRLAEVGDFQDLPIWRRLVIDTAAAMLAELGGTLVVPMTLLRQEHRDEIFGGLAARRIPVRHVLLAPAETILRERIAGREVPADLPDGEIRVRQWSYDQIEPYKTALASWLTADAYPIDTGALTPYAAALRIAEAVGSGQVPACDIVQTPEPTAETVAAGVLLFDEQDRVLLVDPTYKAGWEFPGGIVERGEAPARAGMREVAEETGIRLADVPALLVVDWEPPAPPGFGGLRLLFDGGRLDSAEAQRLLLPGPELRGWRFASEAEAADLLPPVRYERLRRALRARERGKAMYLEAGVPVG
>NZ_CP022310.1|WP_142196852.1|6980790_6981543_-|MBL-fold-metallo-hydrolase
MDVIELLPRLHLLRFPVGQAYLWRDGRAGTDSGLTLIDAGPAGSGTPIAEALAALGHRPRDVRRVVLTHFHEDHAGGAAEVAALTGAEVLAHRLDAPHVRGEVPGPQPVFEDWERPLHERAVRLLPPPDFGHPAEVTELADGDVLDVGGGAHVVHVPGHTHGSIALHLPRHGVLFTGDTVAASPVDGTVMPGVFNLDRRQVLSACRRLAALDADVACFGHGDPVTTGAGRAMRAAAEAALRAEGDGTTGH
>NZ_CP022310.1|WP_142233662.1|6981618_6982980_-|M20/M25/M40-family-metallo-hydrolase
MSSNPVAATVASLMPRAKEELTELVAFKSVADFDQFPREESEGAARWIADALTAEGFEDVALLDTPDGTQSVYGHLPGPEGAKTVLLYAHYDVQPPLDEAGWATPPFELTERDGRWYGRGSADCKGGVVMHLLALRALKANGGVPVHVKMIVEGSEEQGTGGLERYAEDHPELLQADTIVIGDAGNFRVGLPTVTSTLRGMTLVRVRVDTLEGNLHSGQFGGAAPDALAALVRVLDSLRAEDGSTTVDGLTVDSAWDGLQYDEEQFRKDAKVLDGVQLIGSGTVADRIWARPAVTVLGIDCPPVVGATPSVQASARALISLRVPPGVDAAEATRLLRAHLESRTPWGARVSTEQIGQGQAFRADTTSPAYRAMAEAMAVAYPGQEMQYAGQGGSIPLCNTLASLYPKAEILLIGLSEPEAQIHAVNESVSPEELERLSVAEALFLRNYASGAN
>NZ_CP022310.1|WP_142233663.1|6983174_6984413_+|geranylgeranyl-reductase-family-protein
MSSENSSADDVRQVWDVVVVGAGPAGASAAYAAAVAGRRVLLLEKAELPRYKTCGGGIIGPSRDALPPGFELPLKDRVHAVTFSHNGRFSRTRRSRQMMFGLVNRPEFDQQLVEHAQKAGAELRTGVAVQRVEQHGSAVPDRRTVAVVLQGGETVLARAVVGADGSAGRIGAHVGVKVDQVDLGLEAEIPVPDTVAEDWKGRVLIDWGPMPGSYGWVFPKGDTLTVGVISRRGEGAATKRYLEDFIGRLGLAGFEPSISSGHLTRCRADDSPLSRGRVLVCGDAAGLLEPWTREGISFALRSGRLAGEWAVRIAEAHDAVDTRRQALNYAFAVKAGLGVEMSVGKRMLAAFERRPGVFHAVLTGFRPAWNAFRDITRGSTTLGELVRTHPLAHRALMALDRRPADAPEETGS
>NZ_CP022310.1|WP_142196855.1|6984679_6985972_+|sensor-histidine-kinase
MDEQRGPGDGPPRWWRHGQPPRWWRYGPPGWARPADEPADAHDGDGEHGEEHRPRWPWRSTALLTAFVLIGSHFAQEGQAGERIALDPFARALLLASGAMLLWRKRHPVPVVFGTVAAVLLYLGAGYPYGPLFLVVAVACFNAVVSGHRRAAWTAVGTLWAGHMLLAHLLYRWLPPSGDRAASWNQELVTAAWAVALVAVSELARARHEQWARERAERAQAARRRADEERLRIARELHDVLAHSISVINVQAGVGLALLDNDPEQARTALTTIKAKSKEALGEVRQVLDTLRAPGAAPRSPAPGLDRLPELVEQAAGAGLTVTVEGEAPHLPPGADLAAFRIVQEALTNVVRHSGSREARVRIERTGGRLRLRIDDDGPATGADAGGSGNGLAGMRERAAALDGTIEAGPRPDGGFRVLAVLPLEVKEDR
>NZ_CP022310.1|WP_142196856.1|6985968_6986634_+|response-regulator
MIRVLLADDQSLVRAGFRALLDAQPDIEVAGEASDGEEAVRLVGELRPDVVLMDIRMPGLDGLAATRRVTGNAELGDVKVVMLTTFELDEYVFEAIRSGASGFLVKDTEPDELLRAVRAVVEGDALLSPGVTRRLIAEFAARSKEPAAAGALAGLTEREREVMALVGIGLSNEEIARRLVVSPLTAKTHVSRTMVKLGARDRAQLVVLAYESGLVRPGWLG
>NZ_CP022310.1|WP_142196857.1|6986762_6987155_+|MarR-family-transcriptional-regulator
MAAKQAEQALVDRWRAVRALHARTQCEIDRALHGHGLCASDFEVLDILAEGTGSGGCSYRVQEISESVHLSQSALSRLIARLEKEGLVERGMCPEDRRGVRVSLTGKGRALHGEMLPVQRAVLARMLADG
>NZ_CP022310.1|WP_142233664.1|6987173_6987920_-|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MDTASFVGILEKEGQLLADAAQVAGPDAVVPACPGWRTRDLLRHTGVVHRWAAAFVADRHTAPRPMDPHPELDGPDLVAWYRDSHRRLVDTLAGAAPDVECFTFLPGPPSALAFWARRQAHETTVHRYDAESARGGSPAPVAVEFAVDGVDELLRGFHARPKSRVRTASPRVLRVRATDADADADAVWTVRLSQEPPVTVRDADGDAECELAGPAEELYLALWNRRPLPAVSGDAELAALWRDTSAVV
>NZ_CP022310.1|WP_142196859.1|6987989_6988868_-|SDR-family-oxidoreductase
MTEQQNPAERHPTPDFPAQDQPHPGWTGPMDPPPDHGEDTYRGSGRLADRKALITGGDSGIGRAVALAFAREGADVLFTHLDSEKDEAAETARWVEEAGRRAVAVECDVREEDNCRALVDRAVAEFGRIDILVNNAAYQMSQPDGIEAISTEQFDRVMRTNLYGMFWLCKLALPHMPEGGSIINSASVQAYKPSPHLLDYATTKGAIVTFTQGLAQMLIGRGIRVNAVAPGPVWTPLIPATLPDTTEFGKQAPIGRPAQPAEMAPAYVFLASQEASYITAEIVNATGGTPLP

Crispr_ID: NZ_CP022310_22

• CRISPR_ID: NZ_CP022310_22
• CRISPR_location: 7034584-7034752
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_22

Consensus_repeat	Method
GCCGCACGAGCAGGGCTCCGTACGAGCCGCTCAGCGTGTG	CRISPRCasFinder

spacers of NZ_CP022310_22

>22.1|7034624|89|NZ_CP022310|CRISPRCasFinder
AGCAGGGCTCCGTACGAGCCGCTCAGCGTGTGAGCACCGCAGCGCACGCGTTTCGGCCTCGTACGAGACGCTCACCTTGTGAGCACGGC

CRISPR arrays and Neighbor proteins around NZ_CP022310_22

CRISPR arrays

The CRISPR arrays of NZ_CP022310_22

>merge|NZ_CP022310|22|7034584-7034752|CRISPRCasFinder
GCCGTACGAGCAGGGCTCCGTACGAGCACGGTGCCGCACGAGCAGGGCTCCGTACGAGCCGCTCAGCGTGTGAGCACCGCAGCGCACGCGTTTCGGCCTCGTACGAGACGCTCACCTTGTGAGCACGGCGCCGCACGAGCAGAGCTCCGTACGAGCCGCTCAGCGTGTG

>NZ_CP022310|22|19|7034584-7034752|CRISPRCasFinder
GCCGTACGAGCAGGGCTCCGTACGAGCACGGTGCCGCACG	AGCAGGGCTCCGTACGAGCCGCTCAGCGTGTGAGCACCGCAGCGCACGCGTTTCGGCCTCGTACGAGACGCTCACCTTGTGAGCACGGC
GCCGCACGAGCAGAGCTCCGTACGAGCCGCTCAGCGTGTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142233682.1|7037789_7038269_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240032
NZ_CP022310.1|WP_142196900.1|7038324_7039125_+|3-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl|CDD|211705
NZ_CP022310.1|WP_142233683.1|7039212_7041201_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|376570
NZ_CP022310.1|WP_142233685.1|7045606_7046971_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233684.1|7041329_7042715_-|MFS-transporter	unknown	unknown	gnl|CDD|340927
NZ_CP022310.1|WP_142233677.1|7028999_7029824_-|MOSC-domain-containing-protein	unknown	unknown	gnl|CDD|225758
NZ_CP022310.1|WP_142196904.1|7047271_7047553_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142234280.1|7023274_7025533_+|lipase-family-protein	unknown	unknown	gnl|CDD|378390
NZ_CP022310.1|WP_161175889.1|7033126_7033921_+|glutamate-racemase	unknown	unknown	gnl|CDD|234851
NZ_CP022310.1|WP_142196896.1|7033971_7034517_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142234282.1|7043972_7045592_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173812
NZ_CP022310.1|WP_142234281.1|7030590_7031886_+|Tellurium-resistance	unknown	unknown	gnl|CDD|376767
NZ_CP022310.1|WP_142196891.1|7028297_7028903_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_167530143.1|7047586_7048465_-|hypothetical-protein	unknown	unknown	gnl|CDD|375529
NZ_CP022310.1|WP_167530142.1|7043509_7043674_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142196889.1|7022068_7022908_-|DeoR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224268
NZ_CP022310.1|WP_142233678.1|7031892_7033110_-|glycosyltransferase	unknown	unknown	gnl|CDD|213815
NZ_CP022310.1|WP_161173470.1|7025717_7028171_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|163057
NZ_CP022310.1|WP_142233681.1|7036122_7037733_+|apolipoprotein-N-acyltransferase	unknown	unknown	gnl|CDD|223885
NZ_CP022310.1|WP_142196893.1|7029865_7030294_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233682.1|7037789_7038269_+|NUDIX-domain-containing-protein	gnl|CDD|240032	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.65438e-53
NZ_CP022310.1|WP_142196900.1|7038324_7039125_+|3-hydroxybutyrate-dehydrogenase	gnl|CDD|211705	TIGR01963, D-beta-hydroxybutyrate_dehydrogenase, 3-hydroxybutyrate dehydrogenase. This model represents a subfamily of the short chain dehydrogenases. Characterized members so far as 3-hydroxybutyrate dehydrogenases and are found in species that accumulate ester polmers called polyhydroxyalkanoic acids (PHAs) under certain conditions. Several members of the family are from species not known to accumulate PHAs, including Oceanobacillus iheyensis and Bacillus subtilis. However, polymer formation is not required for there be a role for 3-hydroxybutyrate dehydrogenase; it may be members of this family have the same function in those species.	4.82679e-124
NZ_CP022310.1|WP_142233683.1|7039212_7041201_+|GAF-domain-containing-protein	gnl|CDD|376570	pfam01590, GAF, GAF domain. This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	9.48659e-16
NZ_CP022310.1|WP_142233684.1|7041329_7042715_-|MFS-transporter	gnl|CDD|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0
NZ_CP022310.1|WP_142234280.1|7023274_7025533_+|lipase-family-protein	gnl|CDD|378390	pfam10101, DUF2339, Predicted membrane protein (DUF2339). This domain, found in various hypothetical bacterial proteins, has no known function.	0.000177961
NZ_CP022310.1|WP_161173470.1|7025717_7028171_-|AAA-family-ATPase	gnl|CDD|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	3.02425e-92
NZ_CP022310.1|WP_161175889.1|7033126_7033921_+|glutamate-racemase	gnl|CDD|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	5.03275e-48
NZ_CP022310.1|WP_142233677.1|7028999_7029824_-|MOSC-domain-containing-protein	gnl|CDD|225758	COG3217, COG3217, Uncharacterized Fe-S protein [General function prediction only].	1.51744e-59
NZ_CP022310.1|WP_142234282.1|7043972_7045592_+|S8-family-serine-peptidase	gnl|CDD|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.25836e-95
NZ_CP022310.1|WP_142234281.1|7030590_7031886_+|Tellurium-resistance	gnl|CDD|376767	pfam02342, TerD, TerD domain. The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins It is found in a stress response operon with TerB and TerC. TerD has a maximum of two calcium-binding sites depending on the conservation of aspartates. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie at the centre of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways.	4.83634e-62
NZ_CP022310.1|WP_167530143.1|7047586_7048465_-|hypothetical-protein	gnl|CDD|375529	pfam18065, PatG_C, PatG C-terminal. This is the C-terminal domain of Prochloron sp. PatG, which process the precursor peptide to yield the cyclic Patellamide. The C-terminal domain of PatG is 56% structurally homologous to the C-terminal domain of PatA.	5.19954e-38
NZ_CP022310.1|WP_142196889.1|7022068_7022908_-|DeoR-family-transcriptional-regulator	gnl|CDD|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	5.27596e-79
NZ_CP022310.1|WP_142233678.1|7031892_7033110_-|glycosyltransferase	gnl|CDD|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	3.53255e-163
NZ_CP022310.1|WP_142233681.1|7036122_7037733_+|apolipoprotein-N-acyltransferase	gnl|CDD|223885	COG0815, Lnt, Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane].	1.30789e-86
NZ_CP022310.1|WP_142196893.1|7029865_7030294_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.62847e-05

Protein sequences

>NZ_CP022310.1|WP_142196896.1|7033971_7034517_+|hypothetical-protein
MRDHRHGGRTPHSEVWTGRATNRFQWLLALIGAACMALGIALAVDSAWTTGVAPLVMAVVGCIAAGLLVLFGTLAFVHVALRVDEDHLEVRCGHMGVPRRRIPLSHVAGAEFAPHVTPRHWGGWGYRWRPEKGTAVVVRRGEGVVLRLWDGHTFTVTVDDAEAAVHVIRDRLRPGRPGPTR
>NZ_CP022310.1|WP_161175889.1|7033126_7033921_+|glutamate-racemase
MKIALMDSGIGLLAATAAVRRLRPDADLVLSLDPDGMPWGPRTPQDLTERALAVAEAAAAHRPDALIVGCNTATVHALTALRARLEPRLPVVGTVPAIKPAAAGGGPLAIWATPATTGSPYQRDLIRNFAGGVTVTEVPCWGLAEAVERADETAIDAAVAAAAELTPHDVTTVVLGCTHYELVAERIRSAVQRPGRPPLALHGSAGAVAAQALRRLGEQPAPDAPASGTLTVLLSGRQGPLPTAALTYAEGRLLREDAPARTAQ
>NZ_CP022310.1|WP_142233678.1|7031892_7033110_-|glycosyltransferase
MSRRGPFPWGTLRQVSAIVWSAAGSLAAWGWLLLCQGWFWRTDVRLPPSREPEAWPPVCVVVPARDEAAVLPASLPSVLAQDYPGRAEVFLVDDGSTDGTGEVARALARRHGGLPLTVVSPGEPPAGWTGKLWAVRHGIASARARDPEYLLLTDADIAHAPDSLRRLVAAARSGGFDVVSQMARLRVVSLWERLVVPAFVYFFAQLYPFRRIARPGTRTAAAAGGCVLLRAEAAARARIPDAIRHAVIDDVALARAVKRGGGRVWLGLADRVDSVRPYPALRDLWRMVSRSAYTQLRHSPVLLAGTVAGLALVYLVPPVAVVAGAAAGNAVAGGLGAAAWLVMAGTYLPMLRYYRQPPWLAPLLPFTAFLYLLMTVDSAVRHHRGRGAAWKGRTYARPDAVPEEG
>NZ_CP022310.1|WP_142234281.1|7030590_7031886_+|Tellurium-resistance
MPKGSNTPVPATALRVEVGWRSGPGVPDTDASALLLTGGKVRSDDDFVFYNQPAHASGAVRHEGKRDTGGRVTDTLLVDLTRVEPGIETVILAASCDGGTFGQVPDLYIEVEDAGTGTVAARFDSAGATSETAFVLGEFYRRQGAWKFRAVGQGYSSGLEGLATDYGITVDEPQQAAPTAPPAAPPPAAPPVTAPPVTAPPPPAAPPAPAAPPAPPAPVRLTKVTLTKAAPSVSLTKQGGTSGTLHVNLNWQVRKQFSGWAGKLGRPVAMHSDLDLDLCALYELADGRKGVVQALGNAFGALHQPPYIHLDGDDRTGAVSTGENLTVSLDHKQQFRRILVFVTIYEGARSFADLHATVTLQPQFGAPIDFSLDECTVPSTVCALALITNTGGGELVVQREARYLVPERGVSPQRTVDYAYGWGMNWTPGRK
>NZ_CP022310.1|WP_142196893.1|7029865_7030294_-|hypothetical-protein
MTSPRSSYGGGYYSASFPDTPIYDSLVAERGTPQIAPIRVPAAYDAPAAHLPALPSALPALPAAPSQPAYGYPQAPQPAPLQQAPAAYIPQQATAPRGYPGPQPQPPRPAPPAGYEAMRPAAPRPGPAPYQDPYNNQQYRGY
>NZ_CP022310.1|WP_142233677.1|7028999_7029824_-|MOSC-domain-containing-protein
MGKARLHSIHIHPVKAFRSLSLREVDVEPWGPAGDRRWMLIDDGGKVVTQRQNPSLALAAAELLPGGGLRLSAPGAEPVTVAVPAPGGTVPADLFGTKVEVVPAEDEAVHAWCSARLGVAVRLVHLDEPAARRPVDPAFALPGETVSFADGYPLLLTTTASLDHLNSLIAQGEHHAEGPLPMSRFRPNVVVRGTEAWAEDRWTRVTIGEVVFRVAKPSGRCVVTTTDQDTARRGREPLHTLAAHRRTGGRLLFGQNLVPLSRGTVRVGDPVETV
>NZ_CP022310.1|WP_142196891.1|7028297_7028903_-|hypothetical-protein
MRAIGGLRRWRHNPLCRRTDLAEAWLALAALLLVLVAAPLTGLLVGRAADGALQRSVRAQHQARHPVPATVVRRLAPSPLETDPETASGLEARHRVQARWTAPDGTERTGPAPTRLTDPRPGDRFRLWTDRQGRLVARPLDAATATTHAVLAGVGAALVTAGLVECGRRLIVWRMVLRRYARWDQAWGRAGPDWGRTGTGS
>NZ_CP022310.1|WP_161173470.1|7025717_7028171_-|AAA-family-ATPase
MAQGTVQVTHTGTSRWRRRTGEYASLAAALEAAAEGDVLTVAPGTYRENLVVQRAVTLRGPEGSPGSVRIAPVDGVPLTVRASAVVMDLHVEGQDATAPAVLVEEGTPELRDVRVVSRSAAGIEVRGRDARPTVRRCTVDNPAGVGIAVLDGGGGVFEECEVLAAGQAGIAVRGGARPRLERCRVHHASGSGLTASGENSALEAVGCEVYEVRGSGVQVTDRATAHLTDCDVHRTTGDGVTLDTDAVLTLADCRIHDIPENAVDLRSRSVLTLTRTRVRQFGRNGLSVWDPGTRVDANQCEISDSTGDYPAVWVSDGATAVLDSCRVHDVPDALFVLDRGSRADVVDSDLSQVRNTAVSVSDGATAQLDDCRIREAATGAWFRDHGSGGTLGNCTLDGVQTGVIVTKGADPTVERCTIDSPAEAGVYVSAGGRGTFENCRVTGSGGYGFHVIDGSRTTLRKCRTERCARGGYEFAEGGPDAASGPGGPVVEDCTSDESGSLRPPAAPEPAVQTTGHSTGLLSTVPAGRTEQAPSAPASLPAAEPVREARTSKAVLGELDALVGLESVKREVRALTDMIEVGRRRQQAGLKAASVKRHLVFTGAPGTGKTTVARLYGEILASLGVLEQGHLVEVSRVDLVGEHIGSTAIRTQEAFEKARGGVLFIDEAYALSPEDAGRDFGKEAIDTLVKLMEDQRDAVVVIVAGYTAEMERFLSVNPGVASRFSRTITFGDYGPEELLRIVRQQAEEHEYRLAPGAEEALLTYFTDIPKGPAFGNGRTARQTFEAMVERHASRVAQLDEPTTDDLTLLYAEDLPTLP
>NZ_CP022310.1|WP_142234280.1|7023274_7025533_+|lipase-family-protein
MELLIHGVGGTTPQEMLDDPRTVRITGDDTAAVFRRADDADAEREPGRREGPVPEAYVWCNLTSGNGTRALWLLLLPFMVVNLAHWMRPTARGRRRTVRLYGLLVRLAGLSLTVLFVAAACEVALDLAAWQCAGTYACAERHSWLGFLSPAISGDGWWSAPGRRLALAALVPTAVTGLLWLLSLRTWNAYESQQPMSHEPEEDTGRTALNRPGFWYGRRLVARLRAAHTAAGLLTVAAAVGSAAARQDREPGGPTVLAVLGVLLEAVLASGACVVVWVVCRRGRTERRVDGTLDRHLVRYLPLAALVVLALTLLYAGWERPGWKSAGRLPGDAAFGALTLAQGLLVIVLAGVAHTLHRSDPDRRAAIRGLAGPAVAMLACALGGVMSGGVSQRVSDWLDGTGTSMPGPPVLLTWQASVIPPLLVLLLGLAAWLARRAWHIARTERAAVAREYADEAADPGRTRRIASVRAMAALTDRGPRILAALSAATLLLGAGALAGALATDRTPGEATRGSYAVVHGAAETAQALGSWLIGFGFIVLVAGGRRAYKDASARRTIGILWDVGTFWPRAAHPFAPPCYAERAVPDLTWRIATWTRATGGRLVISGHSQGSVLAAAAAWQLPPSTRRRVALLTYGSPLERLYGRWFPAHFGPEALGSLHQEVDCWRNLYRLTDPIGGPVRLPGDDGPDVDRPALRDPLAHGRTATHPLPAPILGHSDYRADPAFAEERRRLLARLRPQVPAPRNTDEPPTGR
>NZ_CP022310.1|WP_142196889.1|7022068_7022908_-|DeoR-family-transcriptional-regulator
MSENQNLLAEQRRTLILDEVRRRGGVRVNELTRKLGVSDMTVRRDLDALARQGVLEKVHGGAVPVVEASTHEPGFEAKSGLELSAKEDIARAAAELVSPGAAIALSGGTTTFALAHRLLDVPDLTVVTNSVRVADVFHAAQRTSGPRQGAATVVLTGGVRTPSDSLVGPVADQAIAALHFDLLFLGVHGISVEAGLSTPNLAEAETNRRLVQSARRVVVVADHTKWGTVGLSSFASLDQVDTLVTDSGLSGDARAQVAEHLRQLVVAGEPDNSADTEDI
>NZ_CP022310.1|WP_142233681.1|7036122_7037733_+|apolipoprotein-N-acyltransferase
MTVTATSVGESAPVPPQTAPSAWRGRLARLLPAAAAASSGLLLYVSFPPRTLWWLALPAFAVLGLVLRGRSWKAGFGLGYLFGLGFLLPLLVWTGVEVGPGPWLALVVIEAVFVALVGAGVAAVSKLPVWPVWAAALWIAGEAARARVPFHGFPWGKVAFGQADGVFLPLAALGGTPVLGFAVVLCGFGLYEVVRTSVSARRTGTVRRAAAVVGVLSVVVPVVAAVAARALVSDKAEDGTVTVAVIQGNVPRLGLDFNSQRRAVLDHHARETERLAAEVAAGTAEQPDIVLWPENSSDIDPFVNDDARAVIDGAAKAIDAPISVGGVVARDGRLLNEQILWDPVKGPVDTYDKRQIQPFGEYLPLRSLVGAVNENWTSMVRQDFSRGGEPGVFRTDGAGVGLVTCYEAAFDWAVRDTVTAGAQLISVPSNNATFGRSEMTYQQLAMSRVRAVEHSRAVTVPVTSGVSAIIAPDGRITQRTGMFVADSLVQEVPLRSSQTPATRLGVLPETALVLVAAGGLGWAVASGVRGRRAGDV
>NZ_CP022310.1|WP_142233682.1|7037789_7038269_+|NUDIX-domain-containing-protein
MATPDFIRTLRASAGHQLLWLPGITALVFDDEGRVLLNRRSDTRKWAVIGGIPEPGEQPAACAVREVEEETAVRCVVERVVLVQALSPVTYDNGDVCQFMDITLRCRAVGGEARVNDDESLEVGWFAVDALPELSEFAHFRIKQAVAEAPTWFDTTGIG
>NZ_CP022310.1|WP_142196900.1|7038324_7039125_+|3-hydroxybutyrate-dehydrogenase
MTAPRALPAPHAPSLDLGGRTALVTGAAGGIGRACALRLAAAGAKVRAVDRDAAGLEALAGAARDLAGTVEPHVLDLTDLDAAELAAAGTDVLVNNAGLQLVRPLEEFPPDVFHTVLTVMLEAPFRLIRGALPHMYGQGWGRIVNVSSVHGLRASAYKSAYVAAKHGLEGLSKTAALEGAPHGVTSNCVNPGYVRTPLVEKQIADQARAHSIPEERVLSEVLLQDSAVKRLIEPAEVAEAVAYLCGPQASFVTGTSLVLDGGWTAH
>NZ_CP022310.1|WP_142233683.1|7039212_7041201_+|GAF-domain-containing-protein
MSRDHVQSAERPSPAAALPGRSHPDTGPGPGSAETPFLELLARGASAEAYEQPVLLARAEAQPAERIAALEQAKLLALRVRSELEERRRREAELSALFETAHDLAGLRDLDAVLRAIVQRARSLLGTDVAYLSLNDPARGDTYMRVTEGSVAARFQQLRLGMGEGLGGLVAQTARPYVTEDYFRDDRFRHTRSIDTGVRDEGLVAILGVPLMLGHHVIGVLFAADRRARVFEREQIALLGSFAALAAAAIDTANLLAETRSAVAGLERANEIIRDRSAVIERASDVHDRLAELVLRGGGVHDVAAAVSQVLDGTVEFTDTTAAPAQALESSRAEGHAVRHRDDWIAAVAAGDELLGALVLRGHPGLDPVDQRTLERAAMVTSLLLLARRSAAEAEQRVRGELLDDLLDARDRDPRLLRERAARLRADLDATHAVLAARLDGGTVDADAEADARRRLWAAASHLAATGQGLAAARDGGTVLLLPLAPGDTATDLARRTARQLGTAVHEPVTVGASAPVEHLTARPDTVAAAYAEARRCLDALRLLGRSGDGSAAEDFGFLGLLLAGERDIAGFVDRTIGQVVAYDERRGTELLRTLDAYFACGMSPARTKDELHVHVNTVAQRLERVGRLLGEDWQSPARVLEIQLALRLHRLSAGPVRPARH
>NZ_CP022310.1|WP_142233684.1|7041329_7042715_-|MFS-transporter
MASAASAPPAPGNLKRIVAASLIGTTIEWYDFFLYGSAAALVFNELFFPESDPLVGTLLSFLTYAVGFAARPLGALVFGHYGDRLGRKKLLVLSLLLMGGATFAIGLLPTHATIGSLAPVLLTVLRLVQGFALGGEWGGAVLLVSEHGDARRRGFWASWPQTGAPAGQLLATGVLSLLTALLSDAAFGSWGWRIPFLLSGVLVIVGLWIRLSVDESPVFKQALEQAEARKADTAAERMPIVAVLRHHWRDVLVAMGARMAENISYYVITAFILVYATTSAGVSKQTALNAVLIASAVHFVVIPAWGALSDRLGRRPVYLIGAAGVGLWMFPFFALIDTGGFANLLLAVTVGLVLHGAMYAPQAAFFSEMFATRMRYSGASIGAQFSSVAAGAPAPLIATALLSAYGSSTPIALYVIAASLLTVVAVALAKETRHRDLADVDPSGGAARPVEAPAAQDARPV
>NZ_CP022310.1|WP_167530142.1|7043509_7043674_-|hypothetical-protein
MAPITRSTIQDIARSGFHHWYYRTATQQLVAGRHSVAREILIEESGGGHGGGPG
>NZ_CP022310.1|WP_142234282.1|7043972_7045592_+|S8-family-serine-peptidase
MHEPEGPFRSPIVGDLNLPPDGTSDKGPASEAPQQRVPMLIELNVLYPGGLLAVREAFYGIWQSYAAMAGGRWPEQFTSESPVQPPVPQGLAPIAPKLYQCVLSRAVVRDLVAEDRSLAERNHRPPTIFRVWPDYRLTPQIDRSAPTVKANAAWRSYDARGHGIVWAVVDSGIDASHPHFSQLELAAAGRGEDQLQGRTSQLHRDFSFLVNPDDPAETVGHGASDGPGDHTMQPLVDENGHGTHVAGIISGCTPDDMKPLVAESNDPGEAGYVQRAHVDKLSGMAPACELVSIKVMRRSRQGTWVTSSSAVIRALTYLRTEVNVDPGILRVHGVNMSLGSEWRPDQYAAGQSPLCQAVNQLVASGVVVVVSAGNFGARTATGESANTSAVLGSITEPAHAEDCIAVGSTHRDAPHAFGVTWTSGKGPTLDGRMKPDVVAPGEWISSAATGQVRAAAGLTPVPGAPLPQSLLTYAEQSGTSMAAPHVSGVIAAFLSARPEFIGRPRQIKRLLTASATDLGRERYAQGAGLVDLMRMLANV
>NZ_CP022310.1|WP_142233685.1|7045606_7046971_+|hypothetical-protein
MTRLTTNEPVWDLRFDEKGRLTAPAEAAFLDQVIAEGVEDLFMFSHGWGTSENMAGELYDDMFPRIREAATGLTGIGNLGFVGVYWPSLWFPPTPATPPSAAGAPQSGSRAVVDLDAGTTALTGREIAASLMPGFADPAQQKTVREIGRLIDEGEEAVGSLMSDAQKEERLRQIHQRLKSLVPPAPQGEFEDSGETALLLTTDPKRGYQAAAEAFGSAPPGSATQGIGDWFNRAVNGAKDAMRVLSYTIMKARAGDIGRGGLGPLLETLHGRSPSVRVHLMGHSFGARLVSFALSGISAREKSPVASLLLLQGAFSHWSFAHAQDNPFGSAGALNAFVNRVHGPLVATFSVHDWAVGVWYPRASFLAGQDSQAQAAGRWGGMGFDGYQAVKPLEDRLMPADGHTDYGFVPGTFYRVNAARVINDVEGQPFAGAHSDIRKGPVAALAAEAAAAHA
>NZ_CP022310.1|WP_142196904.1|7047271_7047553_-|hypothetical-protein
MTNPQFSAEATLDRGLPVHVSPRFEVGPREAEGGIVPQSYPAQCQGAQGFTKTECYGVVEMCQDCCQRYDFGSGYHDVCGTPYVCGACIGLPF
>NZ_CP022310.1|WP_167530143.1|7047586_7048465_-|hypothetical-protein
MAQTPEPVSPPEQSTSSPAQSPANRCPSSGTASPSAPPAFVYAVGQVEPRFPGLAAEKEFAQAMSRVDTAGQTDRQALRSVLDERAGRYLARQICWVFTIEGLETYILVPRDPTDFDLLIEAVRPDPGRHDVDVVIGLRGSNAPPDRCNGLMVPIVAFDQLYSFDRDTLISAIPRPQDQPEDKFQATAAELFDRIGQVADNAGATDEHRALNYLAVRYHAIYTRAAQSHAAEATLSEVEVRRSRLSGARNIVDVIFSYTHRRNDTTERYFVRVDVTEEFPFLVTKLSPFYER

Crispr_ID: NZ_CP022310_23

• CRISPR_ID: NZ_CP022310_23
• CRISPR_location: 7216128-7216730
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 8 spacers
• Cas_protein_info: csb2gr5,cas7,cas8u1,cas3

Consensus repeat of NZ_CP022310_23

Consensus_repeat	Method
CCTGCGATGGGGCCGCGNCCGG	CRT
CCTGCGATGGGGCCGCGGTCTGGCAGG	CRISPRCasFinder

spacers of NZ_CP022310_23

>23.1|7216150|50|NZ_CP022310|CRT
GCAGACCGCGGTCAACCGTTCTGCATTGACGTCATGCACGAGTACCAAAT
>23.2|7216222|49|NZ_CP022310|CRT
AAGGCCGCGGACAGCCAGCGGACGGCTTGCGCCAGTGGATCCTAGCGCT
>23.3|7216293|48|NZ_CP022310|CRT
GCAGGCTGTGGACAGATAGGCCTCCGCCAGCAGCATCAGGTTCTCCTG
>23.4|7216363|50|NZ_CP022310|CRT
GTAGACCGCGGACAGACGGACAAGTTGGACGCTCTGGCAGTCACCGCGGA
>23.5|7216435|47|NZ_CP022310|CRT
GCCGCGGACAGCGAGTGGATGTACTGCGATCCGCCTTACTGGCAAGA
>23.6|7216504|52|NZ_CP022310|CRT
ACAGGCCGCGGACAAGGATCATAGCCTCGTCGAGGACCTTGCAATCCCCGGT
>23.7|7216578|52|NZ_CP022310|CRT
ACAGGCCCCGGACAGACGCGAACTTGTCGATGATCGGACCCGCGACAATGTG
>23.8|7216652|51|NZ_CP022310|CRT
AGAGGCTGCGGACAGAATCAACCTCCCCGGCGGAGTCGAGGCCAACACACT
>23.9|7216583|47|NZ_CP022310|CRISPRCasFinder
CCCCGGACAGACGCGAACTTGTCGATGATCGGACCCGCGACAATGTG
>23.10|7216657|46|NZ_CP022310|CRISPRCasFinder
CTGCGGACAGAATCAACCTCCCCGGCGGAGTCGAGGCCAACACACT

CRISPR arrays and Neighbor proteins around NZ_CP022310_23

CRISPR arrays

The CRISPR arrays of NZ_CP022310_23

>merge|NZ_CP022310|23|7216128-7216730|CRT,CRISPRCasFinder
CCTGCAATGGGGCCGCGACCGGGCAGACCGCGGTCAACCGTTCTGCATTGACGTCATGCACGAGTACCAAATCCTGCGATGGGGCCGCGCCGGGAAGGCCGCGGACAGCCAGCGGACGGCTTGCGCCAGTGGATCCTAGCGCTCCTGCGATGGGGCCACGGCCAGGCAGGCTGTGGACAGATAGGCCTCCGCCAGCAGCATCAGGTTCTCCTGGCTGCGATGGGGCCGCAGCCGGGTAGACCGCGGACAGACGGACAAGTTGGACGCTCTGGCAGTCACCGCGGAGCTGCGATGGGGCCGCGGGCAGGCCGCGGACAGCGAGTGGATGTACTGCGATCCGCCTTACTGGCAAGACCTGCGATGGGGCTGCGGCCGGACAGGCCGCGGACAAGGATCATAGCCTCGTCGAGGACCTTGCAATCCCCGGTCCTGCGATGGGGCCGCGACCGGACAGGCCCCGGACAGACGCGAACTTGTCGATGATCGGACCCGCGACAATGTGCCTGGGATGGGGCCGCGGCCGGAGAGGCTGCGGACAGAATCAACCTCCCCGGCGGAGTCGAGGCCAACACACTCCTGTGATGGGGCCGCAGCTGAGCACAC

>NZ_CP022310|23|4|7216128-7216724|CRT
CCTGCAATGGGGCCGCGACCGG	GCAGACCGCGGTCAACCGTTCTGCATTGACGTCATGCACGAGTACCAAAT
CCTGCGATGGGGCCGCGCCGGG	AAGGCCGCGGACAGCCAGCGGACGGCTTGCGCCAGTGGATCCTAGCGCT
CCTGCGATGGGGCCACGGCCAG	GCAGGCTGTGGACAGATAGGCCTCCGCCAGCAGCATCAGGTTCTCCTG
GCTGCGATGGGGCCGCAGCCGG	GTAGACCGCGGACAGACGGACAAGTTGGACGCTCTGGCAGTCACCGCGGA
GCTGCGATGGGGCCGCGGGCAG	GCCGCGGACAGCGAGTGGATGTACTGCGATCCGCCTTACTGGCAAGA
CCTGCGATGGGGCTGCGGCCGG	ACAGGCCGCGGACAAGGATCATAGCCTCGTCGAGGACCTTGCAATCCCCGGT
CCTGCGATGGGGCCGCGACCGG	ACAGGCCCCGGACAGACGCGAACTTGTCGATGATCGGACCCGCGACAATGTG
CCTGGGATGGGGCCGCGGCCGG	AGAGGCTGCGGACAGAATCAACCTCCCCGGCGGAGTCGAGGCCAACACACT
CCTGTGATGGGGCCGCAGCTGA

>NZ_CP022310|23|20|7216556-7216730|CRISPRCasFinder
CCTGCGATGGGGCCGCGACCGGACAGG	CCCCGGACAGACGCGAACTTGTCGATGATCGGACCCGCGACAATGTG
CCTGGGATGGGGCCGCGGCCGGAGAGG	CTGCGGACAGAATCAACCTCCCCGGCGGAGTCGAGGCCAACACACT
CCTGTGATGGGGCCGCAGCTGAGCACAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_167530150.1|7206357_7206708_-|transposase	unknown	unknown	gnl|CDD|379252
NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	gnl|CDD|274005
NZ_CP022310.1|WP_142233756.1|7198789_7199407_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7	cas7	cd09678_cas7_CAS-I-U	gnl|CDD|378223
NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17	cas8u1	cd09767_cas8u1_CAS-I-U	gnl|CDD|274989
NZ_CP022310.1|WP_142233762.1|7207152_7210371_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase	cas3	cd09696_cas3_CAS-I-U	gnl|CDD|274235
NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379062
NZ_CP022310.1|WP_167529972.1|7206650_7206845_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233763.1|7210664_7211885_-|metallophosphoesterase	unknown	unknown	gnl|CDD|277331
NZ_CP022310.1|WP_142197017.1|7197775_7198636_-|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NZ_CP022310.1|WP_142234293.1|7203710_7204892_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271189
NZ_CP022310.1|WP_142233760.1|7204941_7206297_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_167530153.1|7224481_7229152_-|hypothetical-protein	unknown	unknown	gnl|CDD|223065
NZ_CP022310.1|WP_142233768.1|7230095_7230779_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_167530154.1|7230865_7231018_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233758.1|7202325_7202736_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl|CDD|223619
NZ_CP022310.1|WP_142234292.1|7200354_7202073_+|endo-1,4-beta-xylanase	unknown	unknown	gnl|CDD|366032
NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase	unknown	unknown	gnl|CDD|376751

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	1.3e-42	141.1	18.5
NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7	cas7	cd09678_cas7_CAS-I-U	1e-27	91.9	0.0
NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17	cas8u1	cd09767_cas8u1_CAS-I-U	1.1e-93	309.7	0.3
NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase	cas3	cd09696_cas3_CAS-I-U	1.2e-41	137.1	4.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_167530150.1|7206357_7206708_-|transposase	gnl|CDD|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	7.63537e-05
NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6	gnl|CDD|274005	TIGR02165, CRISPR-associated_protein_GSU0054_family, CRISPR-associated protein GSU0054/csb2, Dpsyc system. This model represents a CRISPR-associated protein from the Dpsyc subtype (a type I-C variant), named for Desulfotalea psychrophila LSv54. CRISPR systems confer resistance in prokaryotes to invasive DNA or RNA, including phage and plasmids. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	5.05419e-28
NZ_CP022310.1|WP_142233756.1|7198789_7199407_+|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	6.20295e-20
NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7	gnl|CDD|378223	pfam09617, Cas_GSU0053, CRISPR-associated protein GSU0053 (Cas_GSU0053). This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	1.17806e-36
NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17	gnl|CDD|274989	TIGR04113, hypothetical_protein_AaLAA1DRAFT_1703, CRISPR-associated protein Csx17, subtype Dpsyc. Members of this protein family are found exclusively in CRISPR-associated (cas) type I system gene clusters of the Dpsyc subtype. Markers for that type include a variant form of cas3 (model TIGR02621) and the GSU0054-like protein family (model TIGR02165). This family occurs in less than half of known Dpsyc clusters.	8.03403e-107
NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase	gnl|CDD|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	4.3908e-79
NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase	gnl|CDD|274235	TIGR02621, CRISPR-associated_helicase_Cas3, CRISPR-associated helicase Cas3, subtype Dpsyc. This model describes a CRISPR-associated putative DEAH-box helicase, or Cas3, of a subtype found in Actinomyces naeslundii MG1, Geobacter sulfurreducens PCA, Gemmata obscuriglobus UQM 2246, and Desulfotalea psychrophila. This protein includes both DEAH and HD motifs.	3.37821e-44
NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	4.08863e-16
NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.000567914
NZ_CP022310.1|WP_142197017.1|7197775_7198636_-|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	3.06521e-38
NZ_CP022310.1|WP_142233763.1|7210664_7211885_-|metallophosphoesterase	gnl|CDD|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.52813e-71
NZ_CP022310.1|WP_142234293.1|7203710_7204892_+|tyrosine-type-recombinase/integrase	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.09446e-17
NZ_CP022310.1|WP_167530153.1|7224481_7229152_-|hypothetical-protein	gnl|CDD|223065	PHA03378, PHA03378, EBNA-3B; Provisional.	0.00046302
NZ_CP022310.1|WP_142233758.1|7202325_7202736_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl|CDD|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	8.62915e-43
NZ_CP022310.1|WP_142234292.1|7200354_7202073_+|endo-1,4-beta-xylanase	gnl|CDD|366032	pfam00331, Glyco_hydro_10, Glycosyl hydrolase family 10.	1.30937e-99

Protein sequences

>NZ_CP022310.1|WP_142233763.1|7210664_7211885_-|metallophosphoesterase
MTDTSNTRPAEGEAQAPRQSRLHRLMRYIPLIAPVLLWAVPCWVLLYAGQHWPLPVTLVGTALFVLGLVGMPLAMVRGHGRRQQDRAAIVGDTLLGTSWVLFTWSVLLGVFLRLALTVADVGESQDRARIVTWAVLGVTAVLLAWGYAEARRVPRVRRLDVQLPRLGVGLDSIRVVLITDTHYGPLDRARWSARVCETVNALEADLVCHTGDIADGTAERRRAQAAPLGTVRATWARVYVTGNHEYYSEAQGWVDLMDELGWEPLRNRHLLLERGGDTLVVAGVDDVTAESSGLAGHRAHLAGALNGADPDLPVLLLAHQPKFVDRAAAAGIDLQLSGHTHGGQIWPFHHLVGLDQPALAGLSHHGTRTLLYTSRGTGFWGPPFRVFAPSEITLLVLRSPHLPTRP
>NZ_CP022310.1|WP_142233762.1|7207152_7210371_+|hypothetical-protein
MSEGSGGVGSVGQGGGLRSIPLDDPLYAAPAQVTAVPLDPKLERLPFLEMLPADFERLLARMLVEVEGLRDVRLFGTHGQKDDGLDVVGRAADGTWHGWQGKRYRTYGPADLQTAVEDHTVRGSGEFPVEELVVCVPCDITRQVTVKLRDLNGFYPNLNIVLLGPDELGDRLRNRPDIVTQFFGQQTAERFCLPVPAPLVIAAPGLDRADLADAARRSPAEALGVDDLLADAARFAQANDHRAAVGKLAEAEVLLARSGFDGHAASVARRRADALINAGDLDEAASLLSDAFWQRADAGDTDGVRSISHRLGEALRSVAAEHPGADTPGHGTALQLFTVMDCAQNLLAHPFPEPKLPAPLQQAPDGLETSLARLAVLAGETSALVDRETVWITEHAERLMQLADAVTDTDDLLAVRLRLTVADATGQWTDLVDAAYRRRHRRILCALILARYARHLAITEGSPGAAEFWKEAVEQACLDGHNADAGEWVHAQRLLHQRTVAMTLPAIDDLDLAKALLARPGRSKLLGAGDLLTKGIGALHDKNLRTAALALRQQVRLSAASGRWFDEHIARRRLAEALLEAGEYDRAADHAVTVGETKIAKNVAKAAAEHFADVTHRLGSEPYWEKATVFRLLGEQADLLPDALVNEVADAALVVATAEDVSATRFPAGNPSPHLAAHDLLAALAGRLDLPRAAQLLSALEPLAPRPKGTYHLTDHAQAAFLAEVATTHPDLRDKALDQILAMLAGNLGDTKALRRASELLHQYGHGRIEQLSVLAADGSWVAAEALAYLTDATSEGHPPSDQKIAQARQALARLTAPRAHTPGRIDLGIGEAVGRDAAQIRVLPEPDRIMAIRALIDRGRGPEAALDRADCIDAAASIATSLTQGAASDGLCETALEAADHDSGPNAADLAMGGMNHQLSGFRINLASTDIRAHWILLAAVVARSTEHAEQVRERILLALPAPADDGGYRLAQALQFLPREVVAPHTLLLAAHPHWAVRSLSAILWAGHAEAPVQLGSLLARDPDVRVRRTLATEMKKRTDHRSSAVATLLAADPRHSVRRLLHGDTSSYR
>NZ_CP022310.1|WP_167529972.1|7206650_7206845_-|hypothetical-protein
MTGSEDADAQRLQFFLSKSTWNDVKVNNRRLQLIAPIRPQPRTISVCWSSTTLGTARTAPPPRA
>NZ_CP022310.1|WP_167530150.1|7206357_7206708_-|transposase
MLVIDDSGDRKDGTTTARLSRLGRTDNGNATVTTVWTDGQGVLPTACTAVHPRPSFRPWPGRPRLHAAAPTSSTHVNGSRLPAAAAGRTSGRHHHKEAAPELLMHSCSAIGDPSGF
>NZ_CP022310.1|WP_142233760.1|7204941_7206297_+|hypothetical-protein
MSTSSTWPDADLPLSPVYPFNDPGVPITLYEGPVGGAGELKVPGVVQYDCSPKPGISWRLRTEEHDPFRVDTDTLRLSDRGIELPVFSTSAVSGWSNGTSFGDPTAALSRVVAHWFNLPRWHGSAHLSSHTSEGAPQCVPAGRSVYQVDGWRITLDVRPDHKSVLSNARQVDVYVMTHVMEIRRLNGTAFTAAEVKPVLGALHVGLSFALGRWVAPALPVGQDDQGEGVWGEWGPMLCDPARSVSSGWWYPEDQVALGDLLACLLPAFRDRRREQSLRLQMQYAITALADRGFVEQRIMIGAAGLEHLMWQNLKLTGRLTETEYNNTRVWPAHRKLRTVLVDAGISLKVKAESLPAAAAFAAEQQASGNQPVDGADIVTRVRNRLVHPKEEQEPVYRIKGLVTDTWLLTRHYLALLILHSMGYRSSYRDLSRTNGWVGETKPAPWATGQRQ
>NZ_CP022310.1|WP_142234293.1|7203710_7204892_+|tyrosine-type-recombinase/integrase
MGSFFKDCGCARPTRCPHPYTIRFRNGLGKQVEEGGFGTQDDAIDRLTQIYAEKKRTAPSVAEARRELGQKSVAEYAKQWLPRQRRMTAYSTGEHVNSSINVHIIPRLGSRKLISVTPIVVERFLDELEADGVGRGNQVNILRTLKAILRDAYDKGAMADDPVKGVQEPEYVRERVVIPNLAYLKQALAVAKDDLALEIVMMAGCGLRNGEARAVNINNLVAEDVYRVHEQIHSNTHRPAKLKHRKVGEFREVPLPRSVREAIERHEAKHGATREGYLLRGPSGYYTEPMERRRVRALFEKLPVVDGMGMYGFRHYFASNALGSGIPITDVAEWMGHKSIEETYRTYRHLMPGSITKAARVLDAGLWDAAEAAVKPVRGWLREPADTFMPGVS
>NZ_CP022310.1|WP_142233758.1|7202325_7202736_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MSELTKPEVDVPEGAAPAELTVRDLVVGDGAEVKPGTVVRVHYIGVTFETGKQFDSSWDRDQPFKFALGSGRVIKGWDRGLRGMKVGGRREIVVPPRLGYGNQSPSPLIPAGSTLVFVVDLLDSYSAGTGGWSNAR
>NZ_CP022310.1|WP_142234292.1|7200354_7202073_+|endo-1,4-beta-xylanase
MRFRKSAVIAVVCALAAGVSADRAGTSAPAGGPVEDLLNGRDWAHFAGGKPTHTGVRVTPLDRRITRQDGTGGQPNPPVNLRGPHVVFRGDVRIEAGLRRTDDTDAYLHLYGETPVIYDEWRYERRSVRIGVVGGRLRIDRWDGDSDRPAMTRTFGSGLGLEVRLAVEVRANRLVLEADGRVVGTVPARDVFASGRIWFGADAGAPGKGWTLTDLHAQSLGRGRMSVVDAPGLRVPRSSDAMRDLAAVLPRPIRMGTALAAGPLLTDSAYRRTAGEEFSMFTPENDFKPQFVQPRRGVFAFAEGDTLVDFAEANRMKVHGHTLVWFEALPAWMRAEMTHEQRRRVMVEHIRAVAGHFRGKVAEWDVVNEPMSDKDEDYVNGNRGVRPQLWFEAMGEQYIDIAFHAAREADPHAVLYLNEYGVEEDGPRWDALYALLIRLKERGVPIDGVGFQDHEYAVGDRTDPEVFRRKVRALAGLGLKARVSEADVLVDEDEEDIQARQLAGKLAVCGEEPNCTSFSTWGFTDKYGSTADLRHYPPSPGNALPWDATYEVKPAYWALRDVLDDARRSGAG
>NZ_CP022310.1|WP_142233756.1|7198789_7199407_+|TetR-family-transcriptional-regulator
MSAAPVGTREISRHAVRAELARVAFNRFCLTGFNQVTFADLAKAAGVSRSTFLRYFGTKEDVVLFVFDPVGDVIADALDADRADQDDWSRLRNALESAVTFLVRDVQELVTILGLIEQTPALCARLREKQAEWRPRIVARLQETTSSTDGSSVIADVRVAAALECLWIVLGQWSASDGEADLGELLDAAFAAFSTPACRPTDAPS
>NZ_CP022310.1|WP_142197017.1|7197775_7198636_-|enoyl-CoA-hydratase/isomerase-family-protein
MSYADLPALTIDVSDGVATVTIDHPPLNLMDAVLLPSLRAFVARVRDDADVRVIVFESADPEFFIAHGDMAYLTDPDALPAATRAAIAAAPGSTVPEGLNILQAMSEEVRSLPQVTIGKLAGFARGAGNEFFMYLDMRFAAIGTSGQGQPESLMGILPGGGGTVNMTRLAGRARALELILGAELVGAELAERYGLINRALPAAELDSFVDTLARRIAGLRPEVISITKAAVDAVAPPIPRAAYAVENEGLFAAFGDEVTELAHKLLAAGIQTREGERDHERIANSI
>NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6
MITLALHFPWKRYHATPWGHFVNEGAVELPPSPWRILRALYSTWKERCPDLDADQVHQVLARLSSPPTYRIPPHHLSHSRHYFPDSTHRSGSSAGTDLALDAFAVLGGDATIYVQWPGDLATDQAKTLAQLAESLPYLGRADSIVEARLLTSADDIPTDTHTPAVQLHDDDLAPKGWTNLELLAPTIPLDLDGLTMRPTDVRARSLLYPPGSRLLPYATALTHPHAQPPAHRPRAKRKTEKITAVRLTINGPGLPPLTQTLPLTDTLRSRCIKPLTPGNGRQAPRHSNLVGKAADGTPLTGHHHAHFLPWDTNHDRRIDEIIIWTPGGLDTEELDAIHQATTGTIGVPEGVPGPRRLHLRITAYGAAADVLPAEWTKPATRYTSLTPFIPVRHPKKRQTLTEFFTAEAARELAHRKHPAPARSKLLQGDWPLYTQHRWTKRETRNDNRPSRGLHLTFDEPISGPLALGRHSHFGLGLLLPTPTSEPQAHQRHAERTEA
>NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7
MRPAFGSTFQPTGFPDIGASTFDTFADDGSTTPSLLVESVQSMANRLEATAWDYGGQQPVDLIADLPYIRVHRASAPEEFLTSSRLEAHRIASAFVREATLDGTKMLDLIASRLGLENDKPLNFPAMADALMGLDPFVLLHGTFFNNKAWWGQPRFTRAVSAVIEAHDVRRAVSGGRKSDSVRHALGDQSEGAGGTSEGYGSVPFHRVEWTAREIHAMFAIDTALLRSYGLGEPRTELLTTLALWEIRSFLDSGLRLRTACDLEPVAKPTGNAGDLPERDELTARIAELLPQVTADLPTHGALTVLWNGEKPKKKTAGGAQ
>NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17
MVSIQIPLRGLRATTLGGYLSALGLLRILATQHDTTTRLRWADDLPVLTSACSIDELTAWLVSSYRPSPIVSPWNAGAGFAGNGKSVEAERALAQVEDSQDPRLAVLREAIAAGRKVVAEGRARGWAGESLWVKQHKQSVISLCRNTFPDEALPWIDVAAVLSGPEVHFNPVAGTGGNFGRQELSATYLQHLALILGPEADHRHAAAWVRAALTGAEDVPYKRGAVGQFDPGRAGGVLASIWGEPDKQGFVNPWRTILTCEGLLLFASAAVRRNAAEPGAAWPFSVHATPIGHPTASAGETAKGEIWAPLWERPANLAELEQLFGEGRARWAGAQAKDGLLFALAISALGVDRNLDAFRRFVIVERLGQNPIAIRATDVPVALRNEHALLAEPYVWLARLRRKDKIPAGVAALLRRCDQALFAAITGSDTTAMARFVISFGRLHEAVARSGRLRQDIAPHQPRQSRVWDPSPGIAGQLELQLASALASLAETRAERAMPALRPLLTRVTRSRDRLVWADSPATGSELLGSTLAQALAQAHRLHLEFLKGTPGDTEAPAAEFPVGQTVALSALESFVDGECDDEVTADYLRGLMALGWTTSQPAPALHGRARNPVLSVLLPFFATGPFRLVSTWGADPVAFTATLRPRPDWIARLIAAGPAGVLDDALLRLQLAGCRPMVGRPPDRASALAAHHTSGTRLAAALLMRVRTRDRTTALSAATATRPDKASPVTT
>NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase
MRRTFVELFRAAMNDVDARPYPYQERLAAEGLPELLRVPTGAGKTAAGVLPWLWRRLEHPDTAVRAGEARWLVFVLPLRSLVEQTAAVVREWTANAGLAGAVRVHVFMGGEGRDDDAWRMDPSRTAVLVGTQDMLLSRLLMRGYGESRAQWPVSFGLLHSGVQFVFDETQLMGPGLPTSAQLQGLREKLGTGAPSRSMWMSATLAPQEVCTPDHREVRGVVELGEDDRVGGLAVRLNAVRQVERVEVPELAAAYPAGVAQVLVARHVSGTRTIAVFNTVERAVAVQAALAKLVRRGGPEVVLLHSRFRPPEREGLMDELKAPLSAAGQIVISTQVLEAGVDLSSRVLFTEAALFSSVVQRAGRCNRTGEFPEGANLLWAPPPSGRGQYAPYEPEDVETAVEALTSLEGTWVTSTRLQEMPVVPKPVVHPVLRRRDLLQLFDTMPDLSGADIDVSQWIRDGQDTTALVAWRDLTDGRPGEREVFPAREELCAAPVRDLKTIVKDSVGPLWVLDAAEGAWRRAQFADIRPGAVLLTSTASGWYDSRLGWGLKHRGPVTSLVRTGRVPDGMSKDDASCADRWVDLIEHLEDVEREVGLLAEGLAPLDGLSAKHLKAARLAGRYHDLGKAHFVFANTVHRSCPEGEQPPGEGPWAKSRHRMGRHERKYFRHELISALALLHPDSTLLDDNEHSDLIAYLAAAHHGKVRVSVRSMPGEAERVPPRVLGVEPAEKVGPVELPGGKILPRIVVDPSVLFLGGGPEGAPSWTQRASQLLSQLGPFRLALLEALVRVADWRASQAYRTPQPAPDQAVSSDEQPSAAPLPIPAPAGAFEQEVLW
>NZ_CP022310.1|WP_167530153.1|7224481_7229152_-|hypothetical-protein
MDALTTAVRTLLEDPDASVDVEVATPEEAARAVQLFDQGLRSGRGVHRRMAEGALQGAETLSTDRLQVLSEFVQNSDDAGAGQLRVLLRSDDMLVAHNGAGLRLADVLPLGMPWLTGKAADAAATGRFGIGLSTLRALSTVWEVHCHPFHVRFSGTQLEPAPPPELPDGISGPEWTVFRIPLAPGKLTSAQLLAWFDEWNDASLLFLRHLRALEVTAGGHSAGLTLAWADVARHRLVVQDVEREVEVRHARTTDGAVWRVYTAQVEARPEWERSHKALDAVVPVGIALPLEGKVAGSVHAGLPVAPLDVATRVHTQFDPVASREGFADSRLNAQLVPVIADLWEAAVRDVLEEVDHTAWHLVPLPCPSGSAPTNLLQDRIRTELLNRARQSLAVKLALPVSQDGPSVPLSDFAVEEAALSGVLDDTDIARLGEARYALPAGVRDSGGRWRKVLADWRTTGAADMRAEVRVMDALTLFSDYEWSDVARLVRLAAVALETGYEHALAGRTCLVTADGRRLRPQPAESAFADASGGATGPLDVLGVVLDLHPAYAEDNVWAKTVTAWLRRRDCLVRRDDTAAMLKIVSLLGKAGGRLADGDEATEAARLIALQQALGEMPKKQRDPLGPGIGRAILLNGFAYDKDGIEQAHRVKPGAAYLPQALESADGDRFEVAARKTPGLIWVRRSYARSLLSAAQAGGLSRTAFLRLLGVADAPRLTPVREVYYPADTKTYPGDPRLGLGRDCRWSVTGRWSQMLVKGADHTLDDLTSSDLFAVVKNIAAEQNVDERRRRTAALLRTLTALLTSSDQAVVPMARGHYKWNVRGETAAIWVWQLRETAWLEDSHGRLKPPADLTLRTPDTVALYGPEDPGYLHPAIHQALATRTEVLTALGVSGNPDVPRLMERLRELRDRANDNTNTDSDVPDSLRAEALLVYQSLARRLTHRSADAPQTAVEKQIRNEFLYEDLVLTDQGWMKPGSCFRGPAILRGFRPFALTGMDVDPLWQALGIPEPGLDDLVDVLKEMSGTGAAPDAEDERVMLDALRRLRDMISSDDKPMPPGLQSRLRNLPLWTTAGWVKGKGRSVFAVADAGVERALTGRLPLWKPGGNVQQFTPLFGRLRVTPLDVAGAQVTYETGDANAAEGALLNQPVDASLTEDFRRGVAALQDLLVRDEPETAEAFTGWTWLADLEVRQLPGLRIRIDPGATHEPITLPVDAQIDRGRNTLFLDSHAALTTKSGAGAAIAAHFAEARSRVGHTWRDVWEERLVEAEAGTALTSAAQRDREERQRLAEELRRRAQLAPVAPTAPTPNVKTTPQRNNNTSPAVPTGPIGFIPPPRTGSAPVSGSPGPGNQSGPQHAPVARPLVDAVVFGVLPDKVTRTGLPPTPSSSPARTPGTGGPAPRRHSTPLPQPRPGGAPPRSKASPLGYEDHDKEELVIQALRRILREQGVELDDQRGASGVGADAYDSTGRYYEIKAHGRAVPSELSLTRSEFVRAWTERENYTLVIASHLEKGAGNPTLRLVNDPVHRFEVEPPTDVRLKGVRDLSVESTMYEWPGTK
>NZ_CP022310.1|WP_142233768.1|7230095_7230779_+|hypothetical-protein
MVELKIPEIYWDDEKAVSLLGEYFTRRRSCGDLFYSGACFEHLGGGGDAEHVADRFDGNDLVAITTLSVSLEPHGAINLLTDPDGHWARLLSLIPRDARLEDPRSDALIAEGGPAWELWERLAGTKQYPGKPDGSGPVVAGKLLARKRPHLIPIYDIRIKQLFERPKTDHSFWAALAAALQADNGAFYDQLARLRDKAGIGEDIGVLRVFDVIAWMHQGRQGQVPTS
>NZ_CP022310.1|WP_167530154.1|7230865_7231018_+|hypothetical-protein
MTHHVECVETTSPRPRALERHFHRLDRDALIFTTIAKGRAGGRLNDGNWR
>NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase
MGDLTAAHRGYEYQDLLEACRVVDLPLGGIVAVHVDEKLVPDDRFDDLTVIGADGCRERTQFKHSDNDDHPLAYDTFTSDGRGLRLDRLVAAAVADRDGPGASARTVRLRIVMRDAPPDDAVLRVVMVPARASDAPFLAGMNTTLLRFEAEALWQGVELPAKGRRKAGNVFGFLAEGDTAVAKEDLEWFCEHLVVELAAPPMTMDLQRPGPAEQLLLQRVRGELGAGIHPNEGRSPADVAEALIRTVRAARQRGIKVTSQELLRRAQLRQDFGAVLRAHPVDRTLEVARPGAVGALVEAAGTAAADGDVLLVTGPPGQGKSWACQQLVEQLTRDGWLVAEHYCYLGDADGDQLTRVMTESVFGSLLGRLAEADPGLVHDQRPRFAADEEALTNAVATALRKDPTRRVALVVDGLDHVTRVHGGRTRRADPSLALAEVLSSLPLPAGSVLIVLSQPGTHLGPLRQAGAATVAVPQLAPEELRGMAERLGLVPSSKGSSQAEALLTDGRDVTDFLDALQERSGGNALYTMYLCREVALRPEAVTDAAATVRALPAYCDSLEDYYAHLYETLGAEADVVADIIALLGMPVTREELGQIVPDRGHRIDRALKVLAPVLSERTGQGEVRVYHESFARYLRLGYQDHPDALQSTLALIATWLSGRGLFEDPRAFRRLLLIFAEAGRDTEVLDHIGRDSVARAVSAAFPASAIRDNLATGLRCAARSGNWPLVVRCVELARAAQTYEGERFDSVLVDFADVPIALLGAQTMADRLLHDGRTVMPARAGLQMCAALDAAGAVAPWREYMTAFQHEDESDNTSYGEDSDRAVSLAWLRGRLRLSAAYREKEEEGPEQDGLSAPVSLDTIAQRLDEDGDQSVADAVVKALLDTVGTDAVTGLLPRLAAGGPVCLSLAEQIAVGVVPGQPGSAAHWARKAAGLGHRPGTVHRLLELGAAADDLSGDLAGDSPTVRRDVLLSLTRDIQQERVRWSPEAVARWLDALAVAAAADPLALDAAEALVQGPGWYPCWLRFAIALVRAESVSVDLRSGLAVEALELLTGDLRPFAGNPRACDLYAIHPLVEVTVRRAVVLVSDDDWLQAWGTLTRVSRGISTTLRGELGGPLPADLLLSIAVEQATPARRASVDEAIQSEFEQQAGGRYYSDLAGYLLTHARLALAAGEPAGAEARWLEACRFLVAYGWHKDITVYEVLDPLPALVAADPARGRARVEQLQPLCERLALHTDGKETLAARREWWRTLAGADPVALARLAASGLLGDCNGPNDLLHGAQENLWHRWKDEADPVVATALRLTLDSPLLEGDAAVLDRLVQTSGPSMPDGVSQLLRCALSRADERPVRYDSSNSDETRASDERRVAELNTVAQRGGAPSIKPLPDLPVAEESRNWSGSPTPASPPAAGDLLADMVLPPVPPGPVGLIRALREWRLRPYGTGTPQQALDRMTNLVGYRLLSLADAGRTDEAVQVLRAIAGPFDFRDGPLLLRQLAEGLERHGQDGLAAEAYALTWVRTRGQGGWLNFGGETSLDALSRAAQIDPVLTFRVVAEEAEAIVSTGRYGTHGVTQALIYAFARQAVGLPGHSSLDLGFALWDEAAAVIESRAPRVHDSDDPDYPYNAPDRDTGAAVHGDLDGAFATAALAGVAHAGREVKRRSMIAARTLVSLRPETAAPAVALALEHASDPATLTWLLCLLEEHGPAGRAVVEYCQDALGVLAQGPLLTVRALARRLLINAAKVPMGPSASDVLQPPVRLWTSSGQEDDRDDQALEGLVREVASARLYEAEQLQPGLIRGVLADARRRLGSEHTKDRYRTQLRAYRSADERLPPDAYLATEEAVEEAVQRTAAGSRAHRLSNGLGVSDPRTWEDQLATALTDSPIVPLAFEAACWPRPGLPTPPGPDDPADSMAGVTAETISVRPLAEADVLSGQALNGWYILASVEKRRLLSLHRRTTDSLSFRFSGLEVIVRGGHETPDVPPFSDGDLIEWAEGPAQLPLGFPQVSFPLFGVDRDMVAAGDAARGLGLPDLTLTPGWWLPAALHLRPGAPLTLEDDHGLALGLICWRTEYERSAYHLAWPRMTGCAVVIRPDLLNVLAERAPATVVIRDFVMRLGPDEEAK
>NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase
MLRTLIKSKIHRATVTQADLHYVGSVTIDADLLDAADLLPGELVHIVDISNGSRLETYVIEGERGSGVIGINGAAAHLVQPGDLVIIISYAQVTDAEARALEPRVVHVDGDNRIVALGADPSEPVPGSDQERSPGAVRA
>NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase
MGDTEIRDDRAAGRLEAVTDGEVVGRIEYFVLDAPERAVVPVHTIVEPAHEGKGIAGSLARELYALAAREDSAVAPLCPYVAKWAERHPEQAPAAGPELIGAAKQWLTAHPERF

Crispr_ID: NZ_CP022310_24

• CRISPR_ID: NZ_CP022310_24
• CRISPR_location: 7216847-7217091
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 3 spacers
• Cas_protein_info: csb2gr5,cas7,cas8u1,cas3

Consensus repeat of NZ_CP022310_24

Consensus_repeat	Method
CCTGCGATGGGGCCGCGGTCTGGCAGG	CRISPRCasFinder

spacers of NZ_CP022310_24

>24.1|7216874|46|NZ_CP022310|CRISPRCasFinder
CCGCGGACAACGGTTGGGCCACGTCGGACAACCGGGACTACAAGGG
>24.2|7216947|44|NZ_CP022310|CRISPRCasFinder
CCGCGGACAGGCGCCTGGATCTCCTTCCTGCTCCCGTGGGTGAC
>24.3|7217018|47|NZ_CP022310|CRISPRCasFinder
CCGCGGACAGATGTGGGCCAGGCGGCCAACGCGGTCGGCCAGATGAT

CRISPR arrays and Neighbor proteins around NZ_CP022310_24

CRISPR arrays

The CRISPR arrays of NZ_CP022310_24

>merge|NZ_CP022310|24|7216847-7217091|CRISPRCasFinder
CCTGCGATGGGTCCGCGGCCAGCCGGGCCGCGGACAACGGTTGGGCCACGTCGGACAACCGGGACTACAAGGGCCTGCGATGGAGCTGCGGCCGGACAGGCCGCGGACAGGCGCCTGGATCTCCTTCCTGCTCCCGTGGGTGACCCTGCGATGGGGCCGCGGTCTGGCAGGCCGCGGACAGATGTGGGCCAGGCGGCCAACGCGGTCGGCCAGATGATCCTGCGATGGGGCCGCGGTCCGGCAGG

>NZ_CP022310|24|21|7216847-7217091|CRISPRCasFinder
CCTGCGATGGGTCCGCGGCCAGCCGGG	CCGCGGACAACGGTTGGGCCACGTCGGACAACCGGGACTACAAGGG
CCTGCGATGGAGCTGCGGCCGGACAGG	CCGCGGACAGGCGCCTGGATCTCCTTCCTGCTCCCGTGGGTGAC
CCTGCGATGGGGCCGCGGTCTGGCAGG	CCGCGGACAGATGTGGGCCAGGCGGCCAACGCGGTCGGCCAGATGAT
CCTGCGATGGGGCCGCGGTCCGGCAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_167530150.1|7206357_7206708_-|transposase	unknown	unknown	gnl|CDD|379252
NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	gnl|CDD|274005
NZ_CP022310.1|WP_142233756.1|7198789_7199407_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7	cas7	cd09678_cas7_CAS-I-U	gnl|CDD|378223
NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17	cas8u1	cd09767_cas8u1_CAS-I-U	gnl|CDD|274989
NZ_CP022310.1|WP_142233762.1|7207152_7210371_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase	cas3	cd09696_cas3_CAS-I-U	gnl|CDD|274235
NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379062
NZ_CP022310.1|WP_167529972.1|7206650_7206845_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233763.1|7210664_7211885_-|metallophosphoesterase	unknown	unknown	gnl|CDD|277331
NZ_CP022310.1|WP_142197017.1|7197775_7198636_-|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
NZ_CP022310.1|WP_142234293.1|7203710_7204892_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271189
NZ_CP022310.1|WP_142233760.1|7204941_7206297_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_167530153.1|7224481_7229152_-|hypothetical-protein	unknown	unknown	gnl|CDD|223065
NZ_CP022310.1|WP_142233768.1|7230095_7230779_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_167530154.1|7230865_7231018_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233758.1|7202325_7202736_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl|CDD|223619
NZ_CP022310.1|WP_142234292.1|7200354_7202073_+|endo-1,4-beta-xylanase	unknown	unknown	gnl|CDD|366032
NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase	unknown	unknown	gnl|CDD|376751

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6	csb2gr5	cls000315_csb2gr5_CAS-I-U	1.3e-42	141.1	18.5
NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7	cas7	cd09678_cas7_CAS-I-U	1e-27	91.9	0.0
NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17	cas8u1	cd09767_cas8u1_CAS-I-U	1.1e-93	309.7	0.3
NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase	cas3	cd09696_cas3_CAS-I-U	1.2e-41	137.1	4.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_167530150.1|7206357_7206708_-|transposase	gnl|CDD|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	7.63537e-05
NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6	gnl|CDD|274005	TIGR02165, CRISPR-associated_protein_GSU0054_family, CRISPR-associated protein GSU0054/csb2, Dpsyc system. This model represents a CRISPR-associated protein from the Dpsyc subtype (a type I-C variant), named for Desulfotalea psychrophila LSv54. CRISPR systems confer resistance in prokaryotes to invasive DNA or RNA, including phage and plasmids. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	5.05419e-28
NZ_CP022310.1|WP_142233756.1|7198789_7199407_+|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	6.20295e-20
NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7	gnl|CDD|378223	pfam09617, Cas_GSU0053, CRISPR-associated protein GSU0053 (Cas_GSU0053). This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	1.17806e-36
NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17	gnl|CDD|274989	TIGR04113, hypothetical_protein_AaLAA1DRAFT_1703, CRISPR-associated protein Csx17, subtype Dpsyc. Members of this protein family are found exclusively in CRISPR-associated (cas) type I system gene clusters of the Dpsyc subtype. Markers for that type include a variant form of cas3 (model TIGR02621) and the GSU0054-like protein family (model TIGR02165). This family occurs in less than half of known Dpsyc clusters.	8.03403e-107
NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase	gnl|CDD|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	4.3908e-79
NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase	gnl|CDD|274235	TIGR02621, CRISPR-associated_helicase_Cas3, CRISPR-associated helicase Cas3, subtype Dpsyc. This model describes a CRISPR-associated putative DEAH-box helicase, or Cas3, of a subtype found in Actinomyces naeslundii MG1, Geobacter sulfurreducens PCA, Gemmata obscuriglobus UQM 2246, and Desulfotalea psychrophila. This protein includes both DEAH and HD motifs.	3.37821e-44
NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	4.08863e-16
NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.000567914
NZ_CP022310.1|WP_142197017.1|7197775_7198636_-|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	3.06521e-38
NZ_CP022310.1|WP_142233763.1|7210664_7211885_-|metallophosphoesterase	gnl|CDD|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.52813e-71
NZ_CP022310.1|WP_142234293.1|7203710_7204892_+|tyrosine-type-recombinase/integrase	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.09446e-17
NZ_CP022310.1|WP_167530153.1|7224481_7229152_-|hypothetical-protein	gnl|CDD|223065	PHA03378, PHA03378, EBNA-3B; Provisional.	0.00046302
NZ_CP022310.1|WP_142233758.1|7202325_7202736_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase	gnl|CDD|223619	COG0545, FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones].	8.62915e-43
NZ_CP022310.1|WP_142234292.1|7200354_7202073_+|endo-1,4-beta-xylanase	gnl|CDD|366032	pfam00331, Glyco_hydro_10, Glycosyl hydrolase family 10.	1.30937e-99

Protein sequences

>NZ_CP022310.1|WP_142233763.1|7210664_7211885_-|metallophosphoesterase
MTDTSNTRPAEGEAQAPRQSRLHRLMRYIPLIAPVLLWAVPCWVLLYAGQHWPLPVTLVGTALFVLGLVGMPLAMVRGHGRRQQDRAAIVGDTLLGTSWVLFTWSVLLGVFLRLALTVADVGESQDRARIVTWAVLGVTAVLLAWGYAEARRVPRVRRLDVQLPRLGVGLDSIRVVLITDTHYGPLDRARWSARVCETVNALEADLVCHTGDIADGTAERRRAQAAPLGTVRATWARVYVTGNHEYYSEAQGWVDLMDELGWEPLRNRHLLLERGGDTLVVAGVDDVTAESSGLAGHRAHLAGALNGADPDLPVLLLAHQPKFVDRAAAAGIDLQLSGHTHGGQIWPFHHLVGLDQPALAGLSHHGTRTLLYTSRGTGFWGPPFRVFAPSEITLLVLRSPHLPTRP
>NZ_CP022310.1|WP_142233762.1|7207152_7210371_+|hypothetical-protein
MSEGSGGVGSVGQGGGLRSIPLDDPLYAAPAQVTAVPLDPKLERLPFLEMLPADFERLLARMLVEVEGLRDVRLFGTHGQKDDGLDVVGRAADGTWHGWQGKRYRTYGPADLQTAVEDHTVRGSGEFPVEELVVCVPCDITRQVTVKLRDLNGFYPNLNIVLLGPDELGDRLRNRPDIVTQFFGQQTAERFCLPVPAPLVIAAPGLDRADLADAARRSPAEALGVDDLLADAARFAQANDHRAAVGKLAEAEVLLARSGFDGHAASVARRRADALINAGDLDEAASLLSDAFWQRADAGDTDGVRSISHRLGEALRSVAAEHPGADTPGHGTALQLFTVMDCAQNLLAHPFPEPKLPAPLQQAPDGLETSLARLAVLAGETSALVDRETVWITEHAERLMQLADAVTDTDDLLAVRLRLTVADATGQWTDLVDAAYRRRHRRILCALILARYARHLAITEGSPGAAEFWKEAVEQACLDGHNADAGEWVHAQRLLHQRTVAMTLPAIDDLDLAKALLARPGRSKLLGAGDLLTKGIGALHDKNLRTAALALRQQVRLSAASGRWFDEHIARRRLAEALLEAGEYDRAADHAVTVGETKIAKNVAKAAAEHFADVTHRLGSEPYWEKATVFRLLGEQADLLPDALVNEVADAALVVATAEDVSATRFPAGNPSPHLAAHDLLAALAGRLDLPRAAQLLSALEPLAPRPKGTYHLTDHAQAAFLAEVATTHPDLRDKALDQILAMLAGNLGDTKALRRASELLHQYGHGRIEQLSVLAADGSWVAAEALAYLTDATSEGHPPSDQKIAQARQALARLTAPRAHTPGRIDLGIGEAVGRDAAQIRVLPEPDRIMAIRALIDRGRGPEAALDRADCIDAAASIATSLTQGAASDGLCETALEAADHDSGPNAADLAMGGMNHQLSGFRINLASTDIRAHWILLAAVVARSTEHAEQVRERILLALPAPADDGGYRLAQALQFLPREVVAPHTLLLAAHPHWAVRSLSAILWAGHAEAPVQLGSLLARDPDVRVRRTLATEMKKRTDHRSSAVATLLAADPRHSVRRLLHGDTSSYR
>NZ_CP022310.1|WP_167529972.1|7206650_7206845_-|hypothetical-protein
MTGSEDADAQRLQFFLSKSTWNDVKVNNRRLQLIAPIRPQPRTISVCWSSTTLGTARTAPPPRA
>NZ_CP022310.1|WP_167530150.1|7206357_7206708_-|transposase
MLVIDDSGDRKDGTTTARLSRLGRTDNGNATVTTVWTDGQGVLPTACTAVHPRPSFRPWPGRPRLHAAAPTSSTHVNGSRLPAAAAGRTSGRHHHKEAAPELLMHSCSAIGDPSGF
>NZ_CP022310.1|WP_142233760.1|7204941_7206297_+|hypothetical-protein
MSTSSTWPDADLPLSPVYPFNDPGVPITLYEGPVGGAGELKVPGVVQYDCSPKPGISWRLRTEEHDPFRVDTDTLRLSDRGIELPVFSTSAVSGWSNGTSFGDPTAALSRVVAHWFNLPRWHGSAHLSSHTSEGAPQCVPAGRSVYQVDGWRITLDVRPDHKSVLSNARQVDVYVMTHVMEIRRLNGTAFTAAEVKPVLGALHVGLSFALGRWVAPALPVGQDDQGEGVWGEWGPMLCDPARSVSSGWWYPEDQVALGDLLACLLPAFRDRRREQSLRLQMQYAITALADRGFVEQRIMIGAAGLEHLMWQNLKLTGRLTETEYNNTRVWPAHRKLRTVLVDAGISLKVKAESLPAAAAFAAEQQASGNQPVDGADIVTRVRNRLVHPKEEQEPVYRIKGLVTDTWLLTRHYLALLILHSMGYRSSYRDLSRTNGWVGETKPAPWATGQRQ
>NZ_CP022310.1|WP_142234293.1|7203710_7204892_+|tyrosine-type-recombinase/integrase
MGSFFKDCGCARPTRCPHPYTIRFRNGLGKQVEEGGFGTQDDAIDRLTQIYAEKKRTAPSVAEARRELGQKSVAEYAKQWLPRQRRMTAYSTGEHVNSSINVHIIPRLGSRKLISVTPIVVERFLDELEADGVGRGNQVNILRTLKAILRDAYDKGAMADDPVKGVQEPEYVRERVVIPNLAYLKQALAVAKDDLALEIVMMAGCGLRNGEARAVNINNLVAEDVYRVHEQIHSNTHRPAKLKHRKVGEFREVPLPRSVREAIERHEAKHGATREGYLLRGPSGYYTEPMERRRVRALFEKLPVVDGMGMYGFRHYFASNALGSGIPITDVAEWMGHKSIEETYRTYRHLMPGSITKAARVLDAGLWDAAEAAVKPVRGWLREPADTFMPGVS
>NZ_CP022310.1|WP_142233758.1|7202325_7202736_-|FKBP-type-peptidyl-prolyl-cis-trans-isomerase
MSELTKPEVDVPEGAAPAELTVRDLVVGDGAEVKPGTVVRVHYIGVTFETGKQFDSSWDRDQPFKFALGSGRVIKGWDRGLRGMKVGGRREIVVPPRLGYGNQSPSPLIPAGSTLVFVVDLLDSYSAGTGGWSNAR
>NZ_CP022310.1|WP_142234292.1|7200354_7202073_+|endo-1,4-beta-xylanase
MRFRKSAVIAVVCALAAGVSADRAGTSAPAGGPVEDLLNGRDWAHFAGGKPTHTGVRVTPLDRRITRQDGTGGQPNPPVNLRGPHVVFRGDVRIEAGLRRTDDTDAYLHLYGETPVIYDEWRYERRSVRIGVVGGRLRIDRWDGDSDRPAMTRTFGSGLGLEVRLAVEVRANRLVLEADGRVVGTVPARDVFASGRIWFGADAGAPGKGWTLTDLHAQSLGRGRMSVVDAPGLRVPRSSDAMRDLAAVLPRPIRMGTALAAGPLLTDSAYRRTAGEEFSMFTPENDFKPQFVQPRRGVFAFAEGDTLVDFAEANRMKVHGHTLVWFEALPAWMRAEMTHEQRRRVMVEHIRAVAGHFRGKVAEWDVVNEPMSDKDEDYVNGNRGVRPQLWFEAMGEQYIDIAFHAAREADPHAVLYLNEYGVEEDGPRWDALYALLIRLKERGVPIDGVGFQDHEYAVGDRTDPEVFRRKVRALAGLGLKARVSEADVLVDEDEEDIQARQLAGKLAVCGEEPNCTSFSTWGFTDKYGSTADLRHYPPSPGNALPWDATYEVKPAYWALRDVLDDARRSGAG
>NZ_CP022310.1|WP_142233756.1|7198789_7199407_+|TetR-family-transcriptional-regulator
MSAAPVGTREISRHAVRAELARVAFNRFCLTGFNQVTFADLAKAAGVSRSTFLRYFGTKEDVVLFVFDPVGDVIADALDADRADQDDWSRLRNALESAVTFLVRDVQELVTILGLIEQTPALCARLREKQAEWRPRIVARLQETTSSTDGSSVIADVRVAAALECLWIVLGQWSASDGEADLGELLDAAFAAFSTPACRPTDAPS
>NZ_CP022310.1|WP_142197017.1|7197775_7198636_-|enoyl-CoA-hydratase/isomerase-family-protein
MSYADLPALTIDVSDGVATVTIDHPPLNLMDAVLLPSLRAFVARVRDDADVRVIVFESADPEFFIAHGDMAYLTDPDALPAATRAAIAAAPGSTVPEGLNILQAMSEEVRSLPQVTIGKLAGFARGAGNEFFMYLDMRFAAIGTSGQGQPESLMGILPGGGGTVNMTRLAGRARALELILGAELVGAELAERYGLINRALPAAELDSFVDTLARRIAGLRPEVISITKAAVDAVAPPIPRAAYAVENEGLFAAFGDEVTELAHKLLAAGIQTREGERDHERIANSI
>NZ_CP022310.1|WP_167530151.1|7217181_7218678_-|type-I-U-CRISPR-associated-protein-Cas5/Cas6
MITLALHFPWKRYHATPWGHFVNEGAVELPPSPWRILRALYSTWKERCPDLDADQVHQVLARLSSPPTYRIPPHHLSHSRHYFPDSTHRSGSSAGTDLALDAFAVLGGDATIYVQWPGDLATDQAKTLAQLAESLPYLGRADSIVEARLLTSADDIPTDTHTPAVQLHDDDLAPKGWTNLELLAPTIPLDLDGLTMRPTDVRARSLLYPPGSRLLPYATALTHPHAQPPAHRPRAKRKTEKITAVRLTINGPGLPPLTQTLPLTDTLRSRCIKPLTPGNGRQAPRHSNLVGKAADGTPLTGHHHAHFLPWDTNHDRRIDEIIIWTPGGLDTEELDAIHQATTGTIGVPEGVPGPRRLHLRITAYGAAADVLPAEWTKPATRYTSLTPFIPVRHPKKRQTLTEFFTAEAARELAHRKHPAPARSKLLQGDWPLYTQHRWTKRETRNDNRPSRGLHLTFDEPISGPLALGRHSHFGLGLLLPTPTSEPQAHQRHAERTEA
>NZ_CP022310.1|WP_142234294.1|7218674_7219640_-|type-I-U-CRISPR-associated-protein-Cas7
MRPAFGSTFQPTGFPDIGASTFDTFADDGSTTPSLLVESVQSMANRLEATAWDYGGQQPVDLIADLPYIRVHRASAPEEFLTSSRLEAHRIASAFVREATLDGTKMLDLIASRLGLENDKPLNFPAMADALMGLDPFVLLHGTFFNNKAWWGQPRFTRAVSAVIEAHDVRRAVSGGRKSDSVRHALGDQSEGAGGTSEGYGSVPFHRVEWTAREIHAMFAIDTALLRSYGLGEPRTELLTTLALWEIRSFLDSGLRLRTACDLEPVAKPTGNAGDLPERDELTARIAELLPQVTADLPTHGALTVLWNGEKPKKKTAGGAQ
>NZ_CP022310.1|WP_167530152.1|7219708_7221907_-|type-I-U-CRISPR-associated-protein-Csx17
MVSIQIPLRGLRATTLGGYLSALGLLRILATQHDTTTRLRWADDLPVLTSACSIDELTAWLVSSYRPSPIVSPWNAGAGFAGNGKSVEAERALAQVEDSQDPRLAVLREAIAAGRKVVAEGRARGWAGESLWVKQHKQSVISLCRNTFPDEALPWIDVAAVLSGPEVHFNPVAGTGGNFGRQELSATYLQHLALILGPEADHRHAAAWVRAALTGAEDVPYKRGAVGQFDPGRAGGVLASIWGEPDKQGFVNPWRTILTCEGLLLFASAAVRRNAAEPGAAWPFSVHATPIGHPTASAGETAKGEIWAPLWERPANLAELEQLFGEGRARWAGAQAKDGLLFALAISALGVDRNLDAFRRFVIVERLGQNPIAIRATDVPVALRNEHALLAEPYVWLARLRRKDKIPAGVAALLRRCDQALFAAITGSDTTAMARFVISFGRLHEAVARSGRLRQDIAPHQPRQSRVWDPSPGIAGQLELQLASALASLAETRAERAMPALRPLLTRVTRSRDRLVWADSPATGSELLGSTLAQALAQAHRLHLEFLKGTPGDTEAPAAEFPVGQTVALSALESFVDGECDDEVTADYLRGLMALGWTTSQPAPALHGRARNPVLSVLLPFFATGPFRLVSTWGADPVAFTATLRPRPDWIARLIAAGPAGVLDDALLRLQLAGCRPMVGRPPDRASALAAHHTSGTRLAAALLMRVRTRDRTTALSAATATRPDKASPVTT
>NZ_CP022310.1|WP_142233766.1|7221900_7224405_-|DEAD/DEAH-box-helicase
MRRTFVELFRAAMNDVDARPYPYQERLAAEGLPELLRVPTGAGKTAAGVLPWLWRRLEHPDTAVRAGEARWLVFVLPLRSLVEQTAAVVREWTANAGLAGAVRVHVFMGGEGRDDDAWRMDPSRTAVLVGTQDMLLSRLLMRGYGESRAQWPVSFGLLHSGVQFVFDETQLMGPGLPTSAQLQGLREKLGTGAPSRSMWMSATLAPQEVCTPDHREVRGVVELGEDDRVGGLAVRLNAVRQVERVEVPELAAAYPAGVAQVLVARHVSGTRTIAVFNTVERAVAVQAALAKLVRRGGPEVVLLHSRFRPPEREGLMDELKAPLSAAGQIVISTQVLEAGVDLSSRVLFTEAALFSSVVQRAGRCNRTGEFPEGANLLWAPPPSGRGQYAPYEPEDVETAVEALTSLEGTWVTSTRLQEMPVVPKPVVHPVLRRRDLLQLFDTMPDLSGADIDVSQWIRDGQDTTALVAWRDLTDGRPGEREVFPAREELCAAPVRDLKTIVKDSVGPLWVLDAAEGAWRRAQFADIRPGAVLLTSTASGWYDSRLGWGLKHRGPVTSLVRTGRVPDGMSKDDASCADRWVDLIEHLEDVEREVGLLAEGLAPLDGLSAKHLKAARLAGRYHDLGKAHFVFANTVHRSCPEGEQPPGEGPWAKSRHRMGRHERKYFRHELISALALLHPDSTLLDDNEHSDLIAYLAAAHHGKVRVSVRSMPGEAERVPPRVLGVEPAEKVGPVELPGGKILPRIVVDPSVLFLGGGPEGAPSWTQRASQLLSQLGPFRLALLEALVRVADWRASQAYRTPQPAPDQAVSSDEQPSAAPLPIPAPAGAFEQEVLW
>NZ_CP022310.1|WP_167530153.1|7224481_7229152_-|hypothetical-protein
MDALTTAVRTLLEDPDASVDVEVATPEEAARAVQLFDQGLRSGRGVHRRMAEGALQGAETLSTDRLQVLSEFVQNSDDAGAGQLRVLLRSDDMLVAHNGAGLRLADVLPLGMPWLTGKAADAAATGRFGIGLSTLRALSTVWEVHCHPFHVRFSGTQLEPAPPPELPDGISGPEWTVFRIPLAPGKLTSAQLLAWFDEWNDASLLFLRHLRALEVTAGGHSAGLTLAWADVARHRLVVQDVEREVEVRHARTTDGAVWRVYTAQVEARPEWERSHKALDAVVPVGIALPLEGKVAGSVHAGLPVAPLDVATRVHTQFDPVASREGFADSRLNAQLVPVIADLWEAAVRDVLEEVDHTAWHLVPLPCPSGSAPTNLLQDRIRTELLNRARQSLAVKLALPVSQDGPSVPLSDFAVEEAALSGVLDDTDIARLGEARYALPAGVRDSGGRWRKVLADWRTTGAADMRAEVRVMDALTLFSDYEWSDVARLVRLAAVALETGYEHALAGRTCLVTADGRRLRPQPAESAFADASGGATGPLDVLGVVLDLHPAYAEDNVWAKTVTAWLRRRDCLVRRDDTAAMLKIVSLLGKAGGRLADGDEATEAARLIALQQALGEMPKKQRDPLGPGIGRAILLNGFAYDKDGIEQAHRVKPGAAYLPQALESADGDRFEVAARKTPGLIWVRRSYARSLLSAAQAGGLSRTAFLRLLGVADAPRLTPVREVYYPADTKTYPGDPRLGLGRDCRWSVTGRWSQMLVKGADHTLDDLTSSDLFAVVKNIAAEQNVDERRRRTAALLRTLTALLTSSDQAVVPMARGHYKWNVRGETAAIWVWQLRETAWLEDSHGRLKPPADLTLRTPDTVALYGPEDPGYLHPAIHQALATRTEVLTALGVSGNPDVPRLMERLRELRDRANDNTNTDSDVPDSLRAEALLVYQSLARRLTHRSADAPQTAVEKQIRNEFLYEDLVLTDQGWMKPGSCFRGPAILRGFRPFALTGMDVDPLWQALGIPEPGLDDLVDVLKEMSGTGAAPDAEDERVMLDALRRLRDMISSDDKPMPPGLQSRLRNLPLWTTAGWVKGKGRSVFAVADAGVERALTGRLPLWKPGGNVQQFTPLFGRLRVTPLDVAGAQVTYETGDANAAEGALLNQPVDASLTEDFRRGVAALQDLLVRDEPETAEAFTGWTWLADLEVRQLPGLRIRIDPGATHEPITLPVDAQIDRGRNTLFLDSHAALTTKSGAGAAIAAHFAEARSRVGHTWRDVWEERLVEAEAGTALTSAAQRDREERQRLAEELRRRAQLAPVAPTAPTPNVKTTPQRNNNTSPAVPTGPIGFIPPPRTGSAPVSGSPGPGNQSGPQHAPVARPLVDAVVFGVLPDKVTRTGLPPTPSSSPARTPGTGGPAPRRHSTPLPQPRPGGAPPRSKASPLGYEDHDKEELVIQALRRILREQGVELDDQRGASGVGADAYDSTGRYYEIKAHGRAVPSELSLTRSEFVRAWTERENYTLVIASHLEKGAGNPTLRLVNDPVHRFEVEPPTDVRLKGVRDLSVESTMYEWPGTK
>NZ_CP022310.1|WP_142233768.1|7230095_7230779_+|hypothetical-protein
MVELKIPEIYWDDEKAVSLLGEYFTRRRSCGDLFYSGACFEHLGGGGDAEHVADRFDGNDLVAITTLSVSLEPHGAINLLTDPDGHWARLLSLIPRDARLEDPRSDALIAEGGPAWELWERLAGTKQYPGKPDGSGPVVAGKLLARKRPHLIPIYDIRIKQLFERPKTDHSFWAALAAALQADNGAFYDQLARLRDKAGIGEDIGVLRVFDVIAWMHQGRQGQVPTS
>NZ_CP022310.1|WP_167530154.1|7230865_7231018_+|hypothetical-protein
MTHHVECVETTSPRPRALERHFHRLDRDALIFTTIAKGRAGGRLNDGNWR
>NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase
MGDLTAAHRGYEYQDLLEACRVVDLPLGGIVAVHVDEKLVPDDRFDDLTVIGADGCRERTQFKHSDNDDHPLAYDTFTSDGRGLRLDRLVAAAVADRDGPGASARTVRLRIVMRDAPPDDAVLRVVMVPARASDAPFLAGMNTTLLRFEAEALWQGVELPAKGRRKAGNVFGFLAEGDTAVAKEDLEWFCEHLVVELAAPPMTMDLQRPGPAEQLLLQRVRGELGAGIHPNEGRSPADVAEALIRTVRAARQRGIKVTSQELLRRAQLRQDFGAVLRAHPVDRTLEVARPGAVGALVEAAGTAAADGDVLLVTGPPGQGKSWACQQLVEQLTRDGWLVAEHYCYLGDADGDQLTRVMTESVFGSLLGRLAEADPGLVHDQRPRFAADEEALTNAVATALRKDPTRRVALVVDGLDHVTRVHGGRTRRADPSLALAEVLSSLPLPAGSVLIVLSQPGTHLGPLRQAGAATVAVPQLAPEELRGMAERLGLVPSSKGSSQAEALLTDGRDVTDFLDALQERSGGNALYTMYLCREVALRPEAVTDAAATVRALPAYCDSLEDYYAHLYETLGAEADVVADIIALLGMPVTREELGQIVPDRGHRIDRALKVLAPVLSERTGQGEVRVYHESFARYLRLGYQDHPDALQSTLALIATWLSGRGLFEDPRAFRRLLLIFAEAGRDTEVLDHIGRDSVARAVSAAFPASAIRDNLATGLRCAARSGNWPLVVRCVELARAAQTYEGERFDSVLVDFADVPIALLGAQTMADRLLHDGRTVMPARAGLQMCAALDAAGAVAPWREYMTAFQHEDESDNTSYGEDSDRAVSLAWLRGRLRLSAAYREKEEEGPEQDGLSAPVSLDTIAQRLDEDGDQSVADAVVKALLDTVGTDAVTGLLPRLAAGGPVCLSLAEQIAVGVVPGQPGSAAHWARKAAGLGHRPGTVHRLLELGAAADDLSGDLAGDSPTVRRDVLLSLTRDIQQERVRWSPEAVARWLDALAVAAAADPLALDAAEALVQGPGWYPCWLRFAIALVRAESVSVDLRSGLAVEALELLTGDLRPFAGNPRACDLYAIHPLVEVTVRRAVVLVSDDDWLQAWGTLTRVSRGISTTLRGELGGPLPADLLLSIAVEQATPARRASVDEAIQSEFEQQAGGRYYSDLAGYLLTHARLALAAGEPAGAEARWLEACRFLVAYGWHKDITVYEVLDPLPALVAADPARGRARVEQLQPLCERLALHTDGKETLAARREWWRTLAGADPVALARLAASGLLGDCNGPNDLLHGAQENLWHRWKDEADPVVATALRLTLDSPLLEGDAAVLDRLVQTSGPSMPDGVSQLLRCALSRADERPVRYDSSNSDETRASDERRVAELNTVAQRGGAPSIKPLPDLPVAEESRNWSGSPTPASPPAAGDLLADMVLPPVPPGPVGLIRALREWRLRPYGTGTPQQALDRMTNLVGYRLLSLADAGRTDEAVQVLRAIAGPFDFRDGPLLLRQLAEGLERHGQDGLAAEAYALTWVRTRGQGGWLNFGGETSLDALSRAAQIDPVLTFRVVAEEAEAIVSTGRYGTHGVTQALIYAFARQAVGLPGHSSLDLGFALWDEAAAVIESRAPRVHDSDDPDYPYNAPDRDTGAAVHGDLDGAFATAALAGVAHAGREVKRRSMIAARTLVSLRPETAAPAVALALEHASDPATLTWLLCLLEEHGPAGRAVVEYCQDALGVLAQGPLLTVRALARRLLINAAKVPMGPSASDVLQPPVRLWTSSGQEDDRDDQALEGLVREVASARLYEAEQLQPGLIRGVLADARRRLGSEHTKDRYRTQLRAYRSADERLPPDAYLATEEAVEEAVQRTAAGSRAHRLSNGLGVSDPRTWEDQLATALTDSPIVPLAFEAACWPRPGLPTPPGPDDPADSMAGVTAETISVRPLAEADVLSGQALNGWYILASVEKRRLLSLHRRTTDSLSFRFSGLEVIVRGGHETPDVPPFSDGDLIEWAEGPAQLPLGFPQVSFPLFGVDRDMVAAGDAARGLGLPDLTLTPGWWLPAALHLRPGAPLTLEDDHGLALGLICWRTEYERSAYHLAWPRMTGCAVVIRPDLLNVLAERAPATVVIRDFVMRLGPDEEAK
>NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase
MLRTLIKSKIHRATVTQADLHYVGSVTIDADLLDAADLLPGELVHIVDISNGSRLETYVIEGERGSGVIGINGAAAHLVQPGDLVIIISYAQVTDAEARALEPRVVHVDGDNRIVALGADPSEPVPGSDQERSPGAVRA
>NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase
MGDTEIRDDRAAGRLEAVTDGEVVGRIEYFVLDAPERAVVPVHTIVEPAHEGKGIAGSLARELYALAAREDSAVAPLCPYVAKWAERHPEQAPAAGPELIGAAKQWLTAHPERF

Crispr_ID: NZ_CP022310_25

• CRISPR_ID: NZ_CP022310_25
• CRISPR_location: 7248239-7248347
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP022310_25

Consensus_repeat	Method
GCCCCGGTCGGCCGAGGCCGCCGGGGC	CRISPRCasFinder

spacers of NZ_CP022310_25

>25.1|7248266|55|NZ_CP022310|CRISPRCasFinder
ATGACGCGGCGGCGGTGGCGGGCCTGGTGGGCCGGTACCCGGTGCGTGCGGTGGT

CRISPR arrays and Neighbor proteins around NZ_CP022310_25

CRISPR arrays

The CRISPR arrays of NZ_CP022310_25

>merge|NZ_CP022310|25|7248239-7248347|CRISPRCasFinder
GCCCCGGTCGGCCGAGGCCGCCGGGGCATGACGCGGCGGCGGTGGCGGGCCTGGTGGGCCGGTACCCGGTGCGTGCGGTGGTGCCCCGGTCGGCCGAGGCCGCCGGGGC

>NZ_CP022310|25|22|7248239-7248347|CRISPRCasFinder
GCCCCGGTCGGCCGAGGCCGCCGGGGC	ATGACGCGGCGGCGGTGGCGGGCCTGGTGGGCCGGTACCCGGTGCGTGCGGTGGT
GCCCCGGTCGGCCGAGGCCGCCGGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022310.1|WP_142233774.1|7243574_7244861_-|DMT-family-transporter	unknown	unknown	gnl|CDD|283340
NZ_CP022310.1|WP_142233772.1|7240161_7241601_-|NADP-dependent-phosphogluconate-dehydrogenase	unknown	unknown	gnl|CDD|236453
NZ_CP022310.1|WP_142234298.1|7260503_7261808_+|cytosine-permease	unknown	unknown	gnl|CDD|271377
NZ_CP022310.1|WP_142234295.1|7244978_7245755_+|ferric-iron-reductase	unknown	unknown	gnl|CDD|274875
NZ_CP022310.1|WP_142233777.1|7251422_7252883_+|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	unknown	unknown	gnl|CDD|274360
NZ_CP022310.1|WP_142233775.1|7245793_7246945_+|glycogen-synthase	unknown	unknown	gnl|CDD|273997
NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|379062
NZ_CP022310.1|WP_142233779.1|7258511_7259426_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379642
NZ_CP022310.1|WP_142197037.1|7255391_7255568_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142197033.1|7246996_7248217_+|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl|CDD|234846
NZ_CP022310.1|WP_142234296.1|7254471_7254921_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP022310.1|WP_142233780.1|7259689_7260430_+|tRNA-dependent-cyclodipeptide-synthase	unknown	unknown	gnl|CDD|275332
NZ_CP022310.1|WP_142233771.1|7238720_7239359_+|arylsulfatase	unknown	unknown	unknown
NZ_CP022310.1|WP_142197036.1|7252955_7254449_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|237218
NZ_CP022310.1|WP_142233773.1|7242286_7243585_+|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl|CDD|366703
NZ_CP022310.1|WP_142233776.1|7248510_7251141_+|glycoside-hydrolase-family-2	unknown	unknown	gnl|CDD|236657
NZ_CP022310.1|WP_167530155.1|7257543_7258515_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase	unknown	unknown	gnl|CDD|376751
NZ_CP022310.1|WP_142234297.1|7255607_7257119_-|MFS-transporter	unknown	unknown	gnl|CDD|129794

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP022310.1|WP_142233774.1|7243574_7244861_-|DMT-family-transporter	gnl|CDD|283340	pfam05653, Mg_trans_NIPA, Magnesium transporter NIPA. NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.	3.27302e-08
NZ_CP022310.1|WP_142233772.1|7240161_7241601_-|NADP-dependent-phosphogluconate-dehydrogenase	gnl|CDD|236453	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase.	0
NZ_CP022310.1|WP_142234298.1|7260503_7261808_+|cytosine-permease	gnl|CDD|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	1.18044e-76
NZ_CP022310.1|WP_142234295.1|7244978_7245755_+|ferric-iron-reductase	gnl|CDD|274875	TIGR03951, Fe_III_red_FhuF, siderophore-iron reductase FhuF. Members of this protein family, including FhuF of E. coli, are siderophore ferric iron reductases that appear to play a role in iron removal from certain hydroxamate-type siderophores, including coprogen, ferrichrome, ferrioxamine B, and aerobactin. Genes occur in regularly in siderophore transport and/or biosynthesis clusters. The C-terminus includes four Cys residues in a C-C-10(X)-C-X-X-C motif that binds a 2Fe-2S cluster. Family TIGR03950 is similar, but especially in the C-terminal region, but likely acts on a different panel of siderophores. [Energy metabolism, Electron transport, Transport and binding proteins, Cations and iron carrying compounds].	5.62898e-08
NZ_CP022310.1|WP_142233777.1|7251422_7252883_+|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	gnl|CDD|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	1.0661e-106
NZ_CP022310.1|WP_142233775.1|7245793_7246945_+|glycogen-synthase	gnl|CDD|273997	TIGR02149, glgA_Coryne, glycogen synthase, Corynebacterium family. This model describes Corynebacterium glutamicum GlgA and closely related proteins in several other species. This enzyme is required for glycogen biosynthesis and appears to replace the distantly related TIGR02095 family of ADP-glucose type glycogen synthase in Corynebacterium glutamicum, Mycobacterium tuberculosis, Bifidobacterium longum, and Streptomyces coelicolor. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.000567914
NZ_CP022310.1|WP_142233779.1|7258511_7259426_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.46098e-27
NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase	gnl|CDD|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	4.08863e-16
NZ_CP022310.1|WP_142197033.1|7246996_7248217_+|glucose-1-phosphate-adenylyltransferase	gnl|CDD|234846	PRK00844, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
NZ_CP022310.1|WP_167530155.1|7257543_7258515_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	8.03149e-20
NZ_CP022310.1|WP_142233780.1|7259689_7260430_+|tRNA-dependent-cyclodipeptide-synthase	gnl|CDD|275332	TIGR04539, CycloL-leucyl-L-phenylalanyl_synthase, tRNA-dependent cyclodipeptide synthase. Members of this family take two aminoacylated tRNA molecules and produce a cyclic dipeptide with two peptide bonds. This enzyme therefore produces a type of nonribosomal peptide, but by a mechanism entirely different from the typical non-ribosomal peptide synthase (NRPS) that relies on adenylation to activate amino acids. Three characterized members of this family are the cyclodityrosine synthase of Mycobacterium tuberculosis (an essential gene), a cyclo(L-Phe-L-Leu) synthase from Streptomyces noursei involved in natural product biosynthesis, and cyclodileucine synthase YvmC from Bacillus licheniformis. Many cyclodipeptide synthases are found next to a cytochrome P450 that further modifies the product.	1.1997e-87
NZ_CP022310.1|WP_142197036.1|7252955_7254449_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|237218	PRK12825, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	1.55763e-12
NZ_CP022310.1|WP_142233773.1|7242286_7243585_+|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	2.26403e-41
NZ_CP022310.1|WP_142233776.1|7248510_7251141_+|glycoside-hydrolase-family-2	gnl|CDD|236657	PRK10150, PRK10150, beta-D-glucuronidase; Provisional.	2.01712e-39
NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase	gnl|CDD|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	4.3908e-79
NZ_CP022310.1|WP_142234297.1|7255607_7257119_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.49865e-54

Protein sequences

>NZ_CP022310.1|WP_142197033.1|7246996_7248217_+|glucose-1-phosphate-adenylyltransferase
MRRGGPSVLGIVLAGGEGKRLMPLTADRAKPAVTFGGTYRLVDFVLSNLVNGDILRICVLTQYKSHSLDRHITTTWRMSSLLGNYVTPVPAQQRLGPRWYLGSADAILQSLNLIYDERPEYVAVFGADHVYRMDPRQMLAQHIESGAGVTVAGIRVPRSESSAFGVITPGSDGRSVERFLEKPTDPPGLADDPERVFASMGNYVFTTKTLIEALQRDAEDENSVHDMGGSILPQLTERGEACLYDFSTNHVPGETSRDQGYWRDVGTLDAYYEAHMDLIAERPAFNLYNRQWPVYTHSGQLSPARFNAGGMASESIISAGCLIRGQVTRSVLSPGVLVDPGAVVQGSVLHDNVHIGRGAVVRGAVLDKNVEVPPGATIGVNPGRDAELYTVSKGGVIALGKGQLVP
>NZ_CP022310.1|WP_142233775.1|7245793_7246945_+|glycogen-synthase
MRVGLLTREYPPDVYGGAGVHVEFLARELRPLVDLEVHCWGEGRTDGVLRHRPWSALDGANDALRTFSVDLAMAAALQGRELVHSHTWYANLGGHLAKLLYGVPHVLTAHSLEPLRPWKAEQLGGGYALSSWAERTAVEAADAVVAVSGAMRDDILGCYPALDPGRVHIVHNGIDTDLYRPDPATDALDRIGIDPSRPYVLFVGRITRQKGVPHLLRAVRGIDPASQVVLCAGAPDTPEIDREFRELYRELSRAREGVHWIPRMLPRPEVIQLLTHAAVFVCPSVYEPLGIVNLEAMACGTAVVASRVGGIPEVVADGSTGVLVDLDDDFEAGLARALDAVLGDPATARRMGAAGRERAVTEFGWDAVARRTVLLYREILEQA
>NZ_CP022310.1|WP_142234295.1|7244978_7245755_+|ferric-iron-reductase
MDLDPSLTALGRLGGFFVLRTTAPPDHRPRTPARTHAPDHRPPTLAQAYVPGRPDVRDDPLSVRVRRVADALGTPETRVAASVAQQGLTARLWSVALGSAALYGAVPDLSPSLLRWDPRGSAPDDLWLTAVRPLPGDAATVAAMVLDGHLRPLTEALRSRHRVAPGLLRGNAASALAGAARELDRWGRGHGRTDVAARAAGLARELLAHPLLSGAGTLTGTAFRRRSCCLYYRVPGGGVCGDCCFPRPPRSSPRGPAA
>NZ_CP022310.1|WP_142233774.1|7243574_7244861_-|DMT-family-transporter
MLRDDDGNKSTRHRVGHGSRPFAAPGPPPRPHAEEQPMSALALSVLLSFVSAVAYAGGAIVQEQVAVSSPGAQQYAPLRRPAWWAAVGLNGLGGLLHVVALAYGPLSLVQPLGALTIVFALPMAALFVGRRAGATAWRGAVMATVGLAGLLSLVGASDVQSLDTPQRVAAALGTAAAVVALMVAARAVHRHPAVRSILLAVASGVAFGMSSVFTKTVAVDWTGGVSAADLPSLTVIGVLATAGMLLSQASYRGAGLAAPLATLTVVNPVVAAAVGITMFGETFRYGSTGTALALSCGVVAAGGLILLTTERLAREQREADQAGGEAPLPVPGPADGEAPVPVPGPADGAAAAGAGSAHAEGAPADPAERLLSELTLPDLAEDVRVPSPAPAREDADDAPWPLVSYAPFYGGPYVPVAVVDRHRVRVKS
>NZ_CP022310.1|WP_142233773.1|7242286_7243585_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MAVRGRHRRYQPNRINRASLTVTAGGAGMALPFMGAGAAQAADADTWEKVAACESSGDWNINTGNGYYGGLQFTQSTWEAYGGTRYAPRADLATRDQQIAVAEKVLDGQGPGAWPACSVRAGLTRGGDVPDVRPAAERSGTREADRRTSVEDVKPHTTPQSRAGRAEMYTVVRGDTLSGIAEDERLRGGWQRLYDANRSTIGDDPDLIVPGQRLALSGGTAKAPERSAKPSKAPERTSKPEAKERADGKTGGEADGGSRKQADRKADRQADRKADRKAEKKSDSRRAADRPERSAPAGAGLVAPVSAGLGTPYHKAGSAWSKGYHTGVDFPVPTGTSVKSVASGTVVAAGWEGSFGYQVVVRHTDGRYSQYAHLSAISVKSGQSVNAGQRIGRSGSTGNSSGPHLHFEVRTGPGFGSDIDPVAYLRAGGVRI
>NZ_CP022310.1|WP_142233772.1|7240161_7241601_-|NADP-dependent-phosphogluconate-dehydrogenase
MSSSAQIGVTGLAVMGRNLARNFARNGYTVAVHNRTAARTHALVEEFGHEGSFVAAETAKEFVAALERPRRLVVMVKAGEPTDAVIEEFAPLLEPGDMIIDGGNAHFADTRRRERELRRKGIHFVGAGISGGEEGALNGPSIMPGGPAESYGSLGPMLEKISAKAADGAPCVTHVGPDGAGHFVKMVHNGIEYADMQLIGEAYQLLRDVAGYAPARIAEIFRTWNTGRLDSYLIEITAEVLSHVDAATGKPFVDVVVDRAEQKGTGRWTVQIALDLGVPVSGIAEAVFARSLSGHAALREASRGLAGPKAAPLGEAEAAAFADRVEQALYASKIVSYTQGFHEIAAGSAEYGWNIDFGAVSAIWRGGCIIRAAFLDRIRAAYDARPDLPSLLSDETFAREIADAQDDWREVLIAATRQGVPTPGFGAALAYYDALRAERLPAALTQGQRDYFGAHTYRRTDRDGSFHTLWGGDRSEVSA
>NZ_CP022310.1|WP_142233771.1|7238720_7239359_+|arylsulfatase
MLALLHTSPVHVPVFDALRDEHHPGLELRHVVVEELLERARAAGPGAVADDVRRRVREAADGGARAVLCTCSTIGDLAERAADGVGVPVLRVDRPMAGAAVAAGPRVVVLAALESTLGPTAALVRDEAARAGRSVEVRTAVVRGAWERFEAGDTAEYVRRVADAADAVTGADVIVLAQASMAPAERLTTTAVPVLSSPRPGLAAGAAAAGLR
>NZ_CP022310.1|WP_161176052.1|7238358_7238703_+|N-acetyltransferase
MGDTEIRDDRAAGRLEAVTDGEVVGRIEYFVLDAPERAVVPVHTIVEPAHEGKGIAGSLARELYALAAREDSAVAPLCPYVAKWAERHPEQAPAAGPELIGAAKQWLTAHPERF
>NZ_CP022310.1|WP_142233770.1|7237904_7238324_+|aspartate-1-decarboxylase
MLRTLIKSKIHRATVTQADLHYVGSVTIDADLLDAADLLPGELVHIVDISNGSRLETYVIEGERGSGVIGINGAAAHLVQPGDLVIIISYAQVTDAEARALEPRVVHVDGDNRIVALGADPSEPVPGSDQERSPGAVRA
>NZ_CP022310.1|WP_142233769.1|7231195_7237555_+|AAA-family-ATPase
MGDLTAAHRGYEYQDLLEACRVVDLPLGGIVAVHVDEKLVPDDRFDDLTVIGADGCRERTQFKHSDNDDHPLAYDTFTSDGRGLRLDRLVAAAVADRDGPGASARTVRLRIVMRDAPPDDAVLRVVMVPARASDAPFLAGMNTTLLRFEAEALWQGVELPAKGRRKAGNVFGFLAEGDTAVAKEDLEWFCEHLVVELAAPPMTMDLQRPGPAEQLLLQRVRGELGAGIHPNEGRSPADVAEALIRTVRAARQRGIKVTSQELLRRAQLRQDFGAVLRAHPVDRTLEVARPGAVGALVEAAGTAAADGDVLLVTGPPGQGKSWACQQLVEQLTRDGWLVAEHYCYLGDADGDQLTRVMTESVFGSLLGRLAEADPGLVHDQRPRFAADEEALTNAVATALRKDPTRRVALVVDGLDHVTRVHGGRTRRADPSLALAEVLSSLPLPAGSVLIVLSQPGTHLGPLRQAGAATVAVPQLAPEELRGMAERLGLVPSSKGSSQAEALLTDGRDVTDFLDALQERSGGNALYTMYLCREVALRPEAVTDAAATVRALPAYCDSLEDYYAHLYETLGAEADVVADIIALLGMPVTREELGQIVPDRGHRIDRALKVLAPVLSERTGQGEVRVYHESFARYLRLGYQDHPDALQSTLALIATWLSGRGLFEDPRAFRRLLLIFAEAGRDTEVLDHIGRDSVARAVSAAFPASAIRDNLATGLRCAARSGNWPLVVRCVELARAAQTYEGERFDSVLVDFADVPIALLGAQTMADRLLHDGRTVMPARAGLQMCAALDAAGAVAPWREYMTAFQHEDESDNTSYGEDSDRAVSLAWLRGRLRLSAAYREKEEEGPEQDGLSAPVSLDTIAQRLDEDGDQSVADAVVKALLDTVGTDAVTGLLPRLAAGGPVCLSLAEQIAVGVVPGQPGSAAHWARKAAGLGHRPGTVHRLLELGAAADDLSGDLAGDSPTVRRDVLLSLTRDIQQERVRWSPEAVARWLDALAVAAAADPLALDAAEALVQGPGWYPCWLRFAIALVRAESVSVDLRSGLAVEALELLTGDLRPFAGNPRACDLYAIHPLVEVTVRRAVVLVSDDDWLQAWGTLTRVSRGISTTLRGELGGPLPADLLLSIAVEQATPARRASVDEAIQSEFEQQAGGRYYSDLAGYLLTHARLALAAGEPAGAEARWLEACRFLVAYGWHKDITVYEVLDPLPALVAADPARGRARVEQLQPLCERLALHTDGKETLAARREWWRTLAGADPVALARLAASGLLGDCNGPNDLLHGAQENLWHRWKDEADPVVATALRLTLDSPLLEGDAAVLDRLVQTSGPSMPDGVSQLLRCALSRADERPVRYDSSNSDETRASDERRVAELNTVAQRGGAPSIKPLPDLPVAEESRNWSGSPTPASPPAAGDLLADMVLPPVPPGPVGLIRALREWRLRPYGTGTPQQALDRMTNLVGYRLLSLADAGRTDEAVQVLRAIAGPFDFRDGPLLLRQLAEGLERHGQDGLAAEAYALTWVRTRGQGGWLNFGGETSLDALSRAAQIDPVLTFRVVAEEAEAIVSTGRYGTHGVTQALIYAFARQAVGLPGHSSLDLGFALWDEAAAVIESRAPRVHDSDDPDYPYNAPDRDTGAAVHGDLDGAFATAALAGVAHAGREVKRRSMIAARTLVSLRPETAAPAVALALEHASDPATLTWLLCLLEEHGPAGRAVVEYCQDALGVLAQGPLLTVRALARRLLINAAKVPMGPSASDVLQPPVRLWTSSGQEDDRDDQALEGLVREVASARLYEAEQLQPGLIRGVLADARRRLGSEHTKDRYRTQLRAYRSADERLPPDAYLATEEAVEEAVQRTAAGSRAHRLSNGLGVSDPRTWEDQLATALTDSPIVPLAFEAACWPRPGLPTPPGPDDPADSMAGVTAETISVRPLAEADVLSGQALNGWYILASVEKRRLLSLHRRTTDSLSFRFSGLEVIVRGGHETPDVPPFSDGDLIEWAEGPAQLPLGFPQVSFPLFGVDRDMVAAGDAARGLGLPDLTLTPGWWLPAALHLRPGAPLTLEDDHGLALGLICWRTEYERSAYHLAWPRMTGCAVVIRPDLLNVLAERAPATVVIRDFVMRLGPDEEAK
>NZ_CP022310.1|WP_142233776.1|7248510_7251141_+|glycoside-hydrolase-family-2
MRIRRLRDRFALLLAAALGVTGLTAAGPAPTAAADDPAEIHGLKGEYYTHSAPGAFDFHELKATAFDSDLDFDNLEPRLNFTTGRSDDVSVRWTGKIVPETTGAHTFSVTADNGFRLWIDGRLAIDHWVDDWDREQTAAPIDLTAGTAHDIKVEYFEHYGGSNFHLRWTEPGGTKEPVPQSAFRLPDGFDYDGALAATVLASGRTLKLDFPRPLAAPPAGFTDHLDAVIGGADWPLTAARPDPDDSKALLVTLAEPVVGNKTGTARGSADLRYDGQGGLTAADGDPVDAFLSSGPNRSTHELRTKWADQVGPDNALPEYPRPQLTRDDWQNLNGRWEFAAAEEGEQPPVGKTLKERILVPYPVESQLSGIQRHEDRMWYRRTFTVPRDWEIGSGKRLRLNFGAVDWRSEVYVNGTKVAAHEGGYDKFAADITDALKPGRTQELIVGVYDPTDAAGGENPPLGKQRLDPSGIWYTPSSGIWQTVWMEPVARDHVDSLELVPDVPGERLTVEAKGVRDGVPVRATAYDGRRKVATASGRTGQPLTLRIDDPHLWSPDDPFLYRLKVTVGADHVGSYFGMRSIAVEQIDGVPRTVLNGEPIFLMATLDQGFWPDGLHTAPTDEALAYDLRAHKELGFNSVRKHIKVEPDRWFYWADRLGLLVWQDMPAMTAGVNPSTEARARYEREMKQMIDEHISSPSVVMWVTFNEGWGQYDIGRIAEQAKAWDPTRLVNNQSGLNLGADGNAGDIMDEHGYPSPALPPRPDGRRALVSGEYGGLGLAVPGHAWPVQQSYVDVDPATYTDDYLTKLDEVRALVCRGSNGAVYTQISDVEGELNGLLTYDRHVMKPDVSRVRAAHQDLIRDASRDRPAGCSGAEGAAR
>NZ_CP022310.1|WP_142233777.1|7251422_7252883_+|wax-ester/triacylglycerol-synthase-family-O-acyltransferase
MTEDPLAPLDLAFWNIESTGHPMHLAALGVFAARSPSAAAHAADLLAARTAAVPGLRMRIRDVWQPPAPRPSLAALRRAFPAPGEPLTAALGRPLVSALRRSLAFGGATREPDPGFDPLDHIRLHPPTACFHTAAGQLMGRPLERTRPPWEAHVLPGEDGTRFAVLFKFHHALADGLRALTLAAALMDPIDLPTPRPRPAAPPRGLLPDVREVPGLVRGALSDAGRALDIGAAVARSTLDMRSSPALTCPPSGTRRTAGAVADLDDVHRIRKSAGGTVNDVLIAVVAGALRRWLDERGDGSDGVAPRALVPVSRRRPRTAHPQGNRLSGYLIRLPVGEPDPLARLGAVRGAMDRNKDAGPHRGAGAVALLADHVPPLGHRIGGPLLGQAARLWFDVLVTSVPLPGFGLRLGGDPLDAVFPLAPLAPGHSLAVAVSTYRGRVHYGLVADGAAVPDLDRLAHAVSEEVKTLITACDGRQGRFGAAARR
>NZ_CP022310.1|WP_142197036.1|7252955_7254449_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTVTEDGPQAADAVAHGPGIDPERLAVCLGVLEELDKLDVDHPDAIAVRRATSHIYRTVKQRRRQERRAAKTAHDKAVTEATATGSAQRIDDETEGILPSSRVEPGAIAGILQRPRSCYVCKTRYVEVDYFYHQLCQNCAAENRARRDARADLTGKRALLTGGRAKIGMYIALRLLRDGAHTTITTRFPKDAIRRFKAMDDSADWIHRLEVVGIDLRDPAQAVALAEQVAEQGPLDILINNATQTVRRLPSAYAALVEGESAPLPAGELPAHHVIGAFNSGAVDGLAALPVGVSGLDAQKVADLALVAGNASVARHRDGTAIDAGGLVPDVVDSNTWVQSIDQISPVELLETQLCNYTAPFILISKLRPAMAEAARRASAGRAYVVNVSAMEGVFARGYKGAGHPNTNAAKAAMNMVTRTSAQEMFDTDRILMTSVDTGWITDERPHYDKLRLAEAGFHAPLDLVDGAARVYDPIVRGEAGEDLYGVFLKDYAPGRW
>NZ_CP022310.1|WP_142234296.1|7254471_7254921_-|hypothetical-protein
MELRTVEELMDLLYACRGTREVPDRGEAPVDAHDHALRTAALLRRGRPADKELQVAGLVRPVGRLLWPGEPTARADRAADAVRALLGERVAGLVRRQPRPDVPADDDLLALRSADEEARTACFDAGVLEDWRTVLELLAARNSRFGMVD
>NZ_CP022310.1|WP_142197037.1|7255391_7255568_+|hypothetical-protein
MTPEKTKTREERPEERTERAARRPGELGSLDVWARSAPIRLAGYEDDLAEPHILPSVD
>NZ_CP022310.1|WP_142234297.1|7255607_7257119_-|MFS-transporter
MGTLSFLGCIDLTIVSTAAPVIQEELGATVTELQLIVNVFVVALSTGMVTAGRLADSHGRRRVLYIGAVIFGLASLGAGFATTPEWLIAFRFVQGAACAALYTATGALVSAIFPPQERGRAIGCLYGVNGLGLAAGPVLGGVLVGSAGRPWVFWLNVPLVLAALAVCLPTVPESYGERPAGGMDRRGPALLCTSVPALVLGLTLGHVRGWSSPGIVALLLYGCAGLVLFGRVELRSPNPLIRFQLFTGRTFLGAVTADFALAFFYCVALFLMPLYLHTVRGFDGHTTGLLMLPCTAVVAALSPLVGRLVDRWGPRRLLCSGFLAIAVSALAQTRLTPATDMPALVAAFAAMGVGWALVLGPATVAALSAVPGHLAGTAVGASWTCHNLGGALGLAAGMEVYRLAARDALADRLAAHEVAADPWAARVVEDPQQGPGLLRRHTDLTAAQARDAFDAMFVAGSRAAMWLLFAVALAALAGIAVGLRPARTAAGARGKERAGVTSP
>NZ_CP022310.1|WP_167530155.1|7257543_7258515_-|LysR-family-transcriptional-regulator
MNIEIQDLRVLRAVADTGTLAGAARALGIDQAGVTRRIQHLERVTGLVALHRDHQGARLTAAGRLLLRCADELLPRIDHLLAAGSRQDPPDPSAERLRIGAVPTPALPLVTAHARALRPSAVVEPRTVPDVCREPADGGHGEDGEDGEDGGETLPELFRVHRLDLAVIRHSAVLDAPLPERFDCAVLAEENLLVGTATGHRLAGRPGLALTDLDGETCLLVGGRRHAGLRRHFTAAVRRAGVRVALHWASDEHEAAALACAVNGALPAFPFPAPAAGVVHTPLSDAVTRHRLLLVWRSDGGAAAWAPRLADLVREAYRGAGPG
>NZ_CP022310.1|WP_142233779.1|7258511_7259426_-|LysR-family-transcriptional-regulator
MDLQLRHLRQLCLVSDTGSLNKAAKALGLPQPALSRQIRRLEELFGGALFERDRHGTRPTPLGSAVLADAQGILRSLDAFAQQLRDYRALRSRTLRIGWAHSVHCVALLNALRPLASHERVQIVAPNSTRELMDLLRAGEVDIALRDHASTSGPPPEGDGRIGYAPWAESPIRVAVAADRPLAAAERLTMADLAGEDWISCSGPDACDEELRRLCASYGFAPRITHDIVMSGPRGQVIRHQGCVALTQARRPVDPGVVQRPVADLDMRVTHLVAFRDWTAPLMPKLVALLSAALRERTPAAELS
>NZ_CP022310.1|WP_142233780.1|7259689_7260430_+|tRNA-dependent-cyclodipeptide-synthase
MLECEPLTERCGGLLSEATHVCIGVSPFNSYFSTPRLRRLAGWALRRFGNVHFFVPDAVAAYTLEALGYEPDRARHKARRQGQYVHNKIATALHTLGVANPDRHVLGMDRLYGTPRYLTLLDEAYRCFQEDEDFRTACLGASHWVLERNLPPGATPGEEQLHSAARYFLAELPLFADAGGIAGHRPSLFVYHQRVAFLERFYRRELSWRPTDGQGFLVVREPVEQRSAAEPAQGPVQPREVARDAG
>NZ_CP022310.1|WP_142234298.1|7260503_7261808_+|cytosine-permease
MDDYSLTPVPDEARHSWFSVAVQRFGQVSSFQQFMVGAVLGYGMTFTDAVIAITVGSVMLEVVTILLGVAGVREGVSTSVLARWSGFGRKGSAAVGMLVAFSLAGWFGVQNGVFAQGMHDLAGWAPEWAWAVVGGAVVTAVSVHGFTTMAWTAYLTVPAFLVLAGWSVADTLAGHAPADLLTGPPPGPVMSLAEGTTLVAGAFILGALMTPDMTRFNRRPSDVVKQTLLGVTLGEYLIGLTAVLLGHAARTADVVGIVTSSSGVLGTLILATAILKINDWNLYSSALATVNSVDVLVGRRVGRRPVTLVIGAVGTALSAVGVTDDFTGFLETIGVLAPPVAGIIIAEYYVVRRYRAVLDAAHRTGALPDRVPDWLPLSLICWAVGAFVGAQVDAGIPAINAVVAAFALYATAGRALRARRGGPAATTPLPDRTT

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP022310_1	1.1|918429|33|NZ_CP022310|CRISPRCasFinder	918429-918461	33	NZ_CP022310.1	918309-918341	0	1.0
NZ_CP022310_5	5.6|2972806|19|NZ_CP022310|CRT	2972806-2972824	19	NZ_CP022310.1	2973060-2973078	0	1.0
NZ_CP022310_5	5.7|2972868|22|NZ_CP022310|CRT	2972868-2972889	22	NZ_CP022310.1	2972995-2973016	0	1.0
NZ_CP022310_10	10.1|3732776|27|NZ_CP022310|CRISPRCasFinder	3732776-3732802	27	NZ_CP022310.1	3732802-3732828	0	1.0
NZ_CP022310_5	5.2|2972552|22|NZ_CP022310|CRT	2972552-2972573	22	NZ_CP022310.1	2972995-2973016	1	0.955
NZ_CP022310_5	5.4|2972679|22|NZ_CP022310|CRT	2972679-2972700	22	NZ_CP022310.1	2972995-2973016	1	0.955
NZ_CP022310_5	5.5|2972744|19|NZ_CP022310|CRT	2972744-2972762	19	NZ_CP022310.1	2973060-2973078	1	0.947
NZ_CP022310_5	5.8|2972933|19|NZ_CP022310|CRT	2972933-2972951	19	NZ_CP022310.1	2973060-2973078	1	0.947

1. spacer 1.1|918429|33|NZ_CP022310|CRISPRCasFinder matches to position: 918309-918341, mismatch: 0, identity: 1.0

tggtgcgggccgccgaggttcggtggttcggga	CRISPR spacer
tggtgcgggccgccgaggttcggtggttcggga	Protospacer
*********************************

2. spacer 5.6|2972806|19|NZ_CP022310|CRT matches to position: 2973060-2973078, mismatch: 0, identity: 1.0

tgagtgcgggtacgtcgcg	CRISPR spacer
tgagtgcgggtacgtcgcg	Protospacer
*******************

3. spacer 5.7|2972868|22|NZ_CP022310|CRT matches to position: 2972995-2973016, mismatch: 0, identity: 1.0

cgtcctcgggcgcgtcaaggcc	CRISPR spacer
cgtcctcgggcgcgtcaaggcc	Protospacer
**********************

4. spacer 10.1|3732776|27|NZ_CP022310|CRISPRCasFinder matches to position: 3732802-3732828, mismatch: 0, identity: 1.0

tgcgtcgcgctcctgcgccgtacacct	CRISPR spacer
tgcgtcgcgctcctgcgccgtacacct	Protospacer
***************************

5. spacer 5.2|2972552|22|NZ_CP022310|CRT matches to position: 2972995-2973016, mismatch: 1, identity: 0.955

cgtcctcgggcgtgtcaaggcc	CRISPR spacer
cgtcctcgggcgcgtcaaggcc	Protospacer
************.*********

6. spacer 5.4|2972679|22|NZ_CP022310|CRT matches to position: 2972995-2973016, mismatch: 1, identity: 0.955

cgtcttcgggcgcgtcaaggcc	CRISPR spacer
cgtcctcgggcgcgtcaaggcc	Protospacer
****.*****************

7. spacer 5.5|2972744|19|NZ_CP022310|CRT matches to position: 2973060-2973078, mismatch: 1, identity: 0.947

tgagtgcgggtacgtcacg	CRISPR spacer
tgagtgcgggtacgtcgcg	Protospacer
****************.**

8. spacer 5.8|2972933|19|NZ_CP022310|CRT matches to position: 2973060-2973078, mismatch: 1, identity: 0.947

tgagtgcgggtacgtcacg	CRISPR spacer
tgagtgcgggtacgtcgcg	Protospacer
****************.**

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022766	Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence	1455303-1455348	0	1.0
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022482	Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence	1654599-1654644	0	1.0
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	570708-570753	0	1.0
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	570708-570753	0	1.0
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022766	Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence	1455296-1455341	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022766	Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence	1455310-1455355	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022482	Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence	1654592-1654637	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022482	Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence	1654606-1654651	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	570701-570746	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	570715-570760	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	570722-570767	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	570701-570746	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	570715-570760	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	570722-570767	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022769	Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence	1462750-1462795	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022769	Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence	1462757-1462802	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022779	Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence	1474231-1474276	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022779	Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence	1474238-1474283	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022793	Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence	1380349-1380394	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022793	Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence	1380356-1380401	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022787	Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence	1414258-1414303	1	0.978
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022787	Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence	1414265-1414310	1	0.978
NZ_CP022310_5	5.7|2972868|22|NZ_CP022310|CRT	2972868-2972889	22	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5671066-5671087	2	0.909
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022766	Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence	1455289-1455334	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022482	Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence	1654613-1654658	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	570729-570774	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	570729-570774	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022769	Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence	1462743-1462788	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022779	Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence	1474224-1474269	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022793	Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence	1380342-1380387	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022787	Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence	1414251-1414296	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP021449	Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence	1273452-1273497	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022773	Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence	1172414-1172459	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022773	Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence	1172407-1172452	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022785	Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence	1361009-1361054	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022785	Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence	1361002-1361047	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022756	Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence	1453143-1453188	2	0.957
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022756	Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence	1453136-1453181	2	0.957
NZ_CP022310_5	5.4|2972679|22|NZ_CP022310|CRT	2972679-2972700	22	NZ_CP010016	Burkholderia thailandensis 34 plasmid unnamed, complete sequence	122488-122509	3	0.864
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022766	Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence	1455282-1455327	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022482	Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence	1654620-1654665	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	570736-570781	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	570736-570781	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022769	Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence	1462736-1462781	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022779	Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence	1474217-1474262	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022793	Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence	1380335-1380380	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022787	Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence	1414244-1414289	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP021449	Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence	1273459-1273504	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022773	Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence	1172400-1172445	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022785	Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence	1360995-1361040	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022756	Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence	1453129-1453174	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1636632-1636677	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022791	Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence	1424413-1424458	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022791	Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence	1424406-1424451	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022781	Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence	579690-579735	3	0.935
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022781	Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence	579697-579742	3	0.935
NZ_CP022310_19	19.1|6562509|25|NZ_CP022310|CRT	6562509-6562533	25	KU530220	Streptomyces phage Xkcd426, complete genome	19978-20002	4	0.84
NZ_CP022310_19	19.2|6562555|25|NZ_CP022310|CRT	6562555-6562579	25	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	2013310-2013334	4	0.84
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1636625-1636670	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP016555	Ralstonia solanacearum FJAT-1458 plasmid plas1, complete sequence	1199720-1199765	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP015851	Ralstonia solanacearum strain YC40-M plasmid, complete sequence	1006802-1006847	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052071	Ralstonia solanacearum strain FJAT454.F1 plasmid Plas1, complete sequence	1562829-1562874	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052075	Ralstonia solanacearum strain FJAT448.F1 plasmid Plas1, complete sequence	1562796-1562841	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052105	Ralstonia solanacearum strain FJAT15252.F1 plasmid Plas1, complete sequence	1561590-1561635	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052077	Ralstonia solanacearum strain FJAT445.F50 plasmid Plas1, complete sequence	1373392-1373437	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052115	Ralstonia solanacearum strain FJAT1463.F50 plasmid Plas1, complete sequence	1561626-1561671	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052079	Ralstonia solanacearum strain FJAT445.F1 plasmid Plas1, complete sequence	1373414-1373459	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052107	Ralstonia solanacearum strain FJAT15249.F50 plasmid Plas1, complete sequence	1561626-1561671	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052117	Ralstonia solanacearum strain FJAT1463.F1 plasmid Plas1, complete sequence	1561615-1561660	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052125	Ralstonia solanacearum strain FJAT1452.F1 plasmid Plas1, complete sequence	1373414-1373459	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052121	Ralstonia solanacearum strain FJAT1458.F1 plasmid Plas1, complete sequence	1561615-1561660	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052123	Ralstonia solanacearum strain FJAT1452.F50 plasmid Plas1, complete sequence	1373414-1373459	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052073	Ralstonia solanacearum strain FJAT448.F50 plasmid Plas1, complete sequence	1562616-1562661	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052081	Ralstonia solanacearum strain FJAT442.F50 plasmid Plas1, complete sequence	1373414-1373459	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052083	Ralstonia solanacearum strain FJAT442.F1 plasmid Plas1, complete sequence	1373414-1373459	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052109	Ralstonia solanacearum strain FJAT15249.F1 plasmid Plas1, complete sequence	1561626-1561671	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052103	Ralstonia solanacearum strain FJAT15252.F50 plasmid Plas1, complete sequence	1561637-1561682	4	0.913
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052119	Ralstonia solanacearum strain FJAT1458.F50 plasmid Plas1, complete sequence	1561438-1561483	4	0.913
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	MN813049	Dickeya phage Ds9CZ, complete genome	1634-1659	5	0.808
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	MN788369	Dickeya phage Ds3CZ, complete genome	1634-1659	5	0.808
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	KY942057	Dickeya phage XF4, complete genome	1634-1659	5	0.808
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	MN813048	Dickeya phage Ds5CZ, complete genome	1634-1659	5	0.808
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	HE600015	Dickeya phage vB_DsoM_LIMEstone1 complete genome	1634-1659	5	0.808
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	MH807812	Dickeya phage Kamild, complete genome	1634-1659	5	0.808
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	KY942056	Dickeya phage JA15, complete genome	1634-1659	5	0.808
NZ_CP022310_19	19.3|6562601|26|NZ_CP022310|CRT	6562601-6562626	26	MG266157	Dickeya phage PP35, complete genome	1634-1659	5	0.808
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022766	Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence	1455317-1455362	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022482	Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence	1654585-1654630	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052111	Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence	570694-570739	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052113	Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence	570694-570739	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022769	Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence	1462764-1462809	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022779	Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence	1474245-1474290	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022793	Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence	1380363-1380408	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022787	Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence	1414272-1414317	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP021449	Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence	1273445-1273490	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022773	Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence	1172421-1172466	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022785	Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence	1361016-1361061	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022756	Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence	1453150-1453195	5	0.891
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1636639-1636684	5	0.891
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP025960	Rhodococcus qingshengii strain djl-6-2 plasmid pDJL1, complete sequence	44749-44782	6	0.824
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022791	Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence	1424420-1424465	6	0.87
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP022781	Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence	579683-579728	6	0.87
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP015205	Rhodococcus sp. 008 plasmid pR8C2, complete sequence	1410-1443	7	0.794
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1782178-1782211	7	0.794
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP017300	Rhodococcus sp. YL-1 plasmid pYLC1, complete sequence	398907-398940	7	0.794
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NC_022125	Rhodococcus erythropolis CCM2595 plasmid pRECF1, complete sequence	23520-23553	7	0.794
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP011297	Rhodococcus erythropolis strain BG43 plasmid pRLLBG43, complete sequence	107580-107613	7	0.794
NZ_CP022310_17	17.1|5824970|33|NZ_CP022310|CRISPRCasFinder	5824970-5825002	33	NZ_CP027239	Dietzia sp. oral taxon 368 strain W5195 plasmid unnamed1, complete sequence	95036-95068	7	0.788
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1636618-1636663	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP016555	Ralstonia solanacearum FJAT-1458 plasmid plas1, complete sequence	1199727-1199772	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP015851	Ralstonia solanacearum strain YC40-M plasmid, complete sequence	1006795-1006840	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052071	Ralstonia solanacearum strain FJAT454.F1 plasmid Plas1, complete sequence	1562836-1562881	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052075	Ralstonia solanacearum strain FJAT448.F1 plasmid Plas1, complete sequence	1562803-1562848	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052105	Ralstonia solanacearum strain FJAT15252.F1 plasmid Plas1, complete sequence	1561597-1561642	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052077	Ralstonia solanacearum strain FJAT445.F50 plasmid Plas1, complete sequence	1373399-1373444	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052115	Ralstonia solanacearum strain FJAT1463.F50 plasmid Plas1, complete sequence	1561633-1561678	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052079	Ralstonia solanacearum strain FJAT445.F1 plasmid Plas1, complete sequence	1373421-1373466	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052107	Ralstonia solanacearum strain FJAT15249.F50 plasmid Plas1, complete sequence	1561633-1561678	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052117	Ralstonia solanacearum strain FJAT1463.F1 plasmid Plas1, complete sequence	1561622-1561667	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052125	Ralstonia solanacearum strain FJAT1452.F1 plasmid Plas1, complete sequence	1373421-1373466	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052121	Ralstonia solanacearum strain FJAT1458.F1 plasmid Plas1, complete sequence	1561622-1561667	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052123	Ralstonia solanacearum strain FJAT1452.F50 plasmid Plas1, complete sequence	1373421-1373466	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052073	Ralstonia solanacearum strain FJAT448.F50 plasmid Plas1, complete sequence	1562623-1562668	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052081	Ralstonia solanacearum strain FJAT442.F50 plasmid Plas1, complete sequence	1373421-1373466	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052083	Ralstonia solanacearum strain FJAT442.F1 plasmid Plas1, complete sequence	1373421-1373466	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052109	Ralstonia solanacearum strain FJAT15249.F1 plasmid Plas1, complete sequence	1561633-1561678	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052103	Ralstonia solanacearum strain FJAT15252.F50 plasmid Plas1, complete sequence	1561644-1561689	7	0.848
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052119	Ralstonia solanacearum strain FJAT1458.F50 plasmid Plas1, complete sequence	1561445-1561490	7	0.848
NZ_CP022310_1	1.1|918429|33|NZ_CP022310|CRISPRCasFinder	918429-918461	33	NZ_CP045385	Ruegeria sp. THAF33 plasmid pTHAF33_a, complete sequence	128084-128116	8	0.758
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP022999	Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence	1517747-1517780	8	0.765
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP040763	Paracoccus sp. 2251 plasmid unnamed4, complete sequence	251361-251394	8	0.765
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP049788	Ralstonia solanacearum strain B2 plasmid unnamed, complete sequence	438099-438144	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP016905	Ralstonia solanacearum strain KACC 10709 plasmid unnamed1	459102-459147	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052095	Ralstonia solanacearum strain FJAT15340.F1 plasmid Plas1, complete sequence	1470152-1470197	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052097	Ralstonia solanacearum strain FJAT15304.F6 plasmid Plas1, complete sequence	1470152-1470197	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052093	Ralstonia solanacearum strain FJAT15340.F50 plasmid Plas1, complete sequence	1470152-1470197	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052101	Ralstonia solanacearum strain FJAT15304.F1 plasmid Plas1, complete sequence	1470152-1470197	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052099	Ralstonia solanacearum strain FJAT15304.F50 plasmid Plas1, complete sequence	1470152-1470197	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052129	Ralstonia solanacearum strain FJAT1303.F1 plasmid Plas1, complete sequence	714994-715039	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP052091	Ralstonia solanacearum strain FJAT15340.F6 plasmid Plas1, complete sequence	1470155-1470200	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP021763	Ralstonia pseudosolanacearum strain RS 476 plasmid unnamed, complete sequence	1459596-1459641	8	0.826
NZ_CP022310_21	21.1|6978804|46|NZ_CP022310|CRISPRCasFinder	6978804-6978849	46	NZ_CP021765	Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence	1459578-1459623	8	0.826
NZ_CP022310_11	11.1|4111955|37|NZ_CP022310|CRISPRCasFinder	4111955-4111991	37	NZ_CP017427	Methylobacterium sp. XJLW plasmid unnamed1, complete sequence	146843-146879	9	0.757
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP013069	Pannonibacter phragmitetus strain 31801 plasmid p.p-1, complete sequence	152239-152272	9	0.735
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP032313	Pannonibacter phragmitetus BB plasmid p.BB_1, complete sequence	332253-332286	9	0.735
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP013744	Streptomyces sp. CdTB01 plasmid unnamed, complete sequence	165987-166020	9	0.735
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP033508	Mesorhizobium jarvisii strain ATCC 700743 plasmid pMJ700743a, complete sequence	100783-100816	9	0.735
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP033369	Mesorhizobium loti strain SU343 plasmid pMLSU343a, complete sequence	100783-100816	9	0.735
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	MK686069	Streptomyces phage Heather, complete genome	36107-36140	9	0.735
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	MH744418	Streptomyces phage JustBecause, complete genome	151755-151788	10	0.706
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	MT310898	Streptomyces phage Kela, complete genome	153360-153393	10	0.706
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	KY676784	Streptomyces phage ToastyFinz, complete genome	20627-20660	10	0.706
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	CP054921	Streptomyces sp. NA03103 plasmid unnamed1, complete sequence	96800-96833	11	0.676
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	NZ_CP054617	Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence	626215-626248	11	0.676
NZ_CP022310_14	14.1|4933372|34|NZ_CP022310|CRISPRCasFinder	4933372-4933405	34	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	690303-690336	11	0.676

1. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022766 (Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
**********************************************

2. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022482 (Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence) position: , mismatch: 0, identity: 1.0

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
**********************************************

3. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 0, identity: 1.0

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
**********************************************

4. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 0, identity: 1.0

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
**********************************************

5. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022766 (Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

6. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022766 (Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

7. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022482 (Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

8. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022482 (Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

9. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

10. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

11. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgct	Protospacer
**************************************.*******

12. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

13. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

14. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgct	Protospacer
**************************************.*******

15. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022769 (Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

16. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022769 (Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

17. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022779 (Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

18. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022779 (Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

19. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022793 (Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

20. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022793 (Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

21. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022787 (Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
*********************************************.

22. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022787 (Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence) position: , mismatch: 1, identity: 0.978

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.*********************************************

23. spacer 5.7|2972868|22|NZ_CP022310|CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 2, identity: 0.909

cgtcctcgggcgcgtcaaggcc	CRISPR spacer
ggtcctcgggctcgtcaaggcc	Protospacer
 ********** **********

24. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022766 (Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

25. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022482 (Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

26. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
*******************************.*************.

27. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
*******************************.*************.

28. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022769 (Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

29. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022779 (Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

30. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022793 (Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

31. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022787 (Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

32. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP021449 (Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
.********************************************.

33. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022773 (Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
.********************************************.

34. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022773 (Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

35. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022785 (Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
.********************************************.

36. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022785 (Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

37. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022756 (Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
.********************************************.

38. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022756 (Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.957

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
**************************************.******.

39. spacer 5.4|2972679|22|NZ_CP022310|CRT matches to NZ_CP010016 (Burkholderia thailandensis 34 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.864

cgtcttcgggcgcgtcaaggcc	CRISPR spacer
gcgcttcgggcgcgtcaaggcc	Protospacer
   *******************

40. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022766 (Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

41. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022482 (Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

42. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
************************.*************.******.

43. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
************************.*************.******.

44. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022769 (Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

45. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022779 (Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

46. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022793 (Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

47. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022787 (Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

48. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP021449 (Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgccgccttca	Protospacer
**************************************.**** * 

49. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022773 (Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

50. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022785 (Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

51. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022756 (Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

52. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cccggcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
. * ******************************************

53. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022791 (Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.*************************************.******.

54. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022791 (Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

55. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022781 (Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.*************************************.******.

56. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022781 (Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.935

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
*******************************.******.******.

57. spacer 19.1|6562509|25|NZ_CP022310|CRT matches to KU530220 (Streptomyces phage Xkcd426, complete genome) position: , mismatch: 4, identity: 0.84

gcgacgcccaggccaccgggactgt	CRISPR spacer
gcgacgtccaggccaacgggactca	Protospacer
******.******** *******  

58. spacer 19.2|6562555|25|NZ_CP022310|CRT matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.84

ttgatgcctaggccaccgcgactgt	CRISPR spacer
ctgaggcccaggccaccgcgactga	Protospacer
.*** ***.*************** 

59. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgctgcctgcttgctgag	Protospacer
***************************************  ***  

60. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP016555 (Ralstonia solanacearum FJAT-1458 plasmid plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

61. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP015851 (Ralstonia solanacearum strain YC40-M plasmid, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.******************************.******.******.

62. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052071 (Ralstonia solanacearum strain FJAT454.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

63. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052075 (Ralstonia solanacearum strain FJAT448.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

64. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052105 (Ralstonia solanacearum strain FJAT15252.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

65. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052077 (Ralstonia solanacearum strain FJAT445.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.******************************.******.******.

66. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052115 (Ralstonia solanacearum strain FJAT1463.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

67. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052079 (Ralstonia solanacearum strain FJAT445.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.******************************.******.******.

68. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052107 (Ralstonia solanacearum strain FJAT15249.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

69. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052117 (Ralstonia solanacearum strain FJAT1463.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

70. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052125 (Ralstonia solanacearum strain FJAT1452.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.******************************.******.******.

71. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052121 (Ralstonia solanacearum strain FJAT1458.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

72. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052123 (Ralstonia solanacearum strain FJAT1452.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.******************************.******.******.

73. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052073 (Ralstonia solanacearum strain FJAT448.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

74. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052081 (Ralstonia solanacearum strain FJAT442.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.******************************.******.******.

75. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052083 (Ralstonia solanacearum strain FJAT442.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.******************************.******.******.

76. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052109 (Ralstonia solanacearum strain FJAT15249.F1 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

77. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052103 (Ralstonia solanacearum strain FJAT15252.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

78. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052119 (Ralstonia solanacearum strain FJAT1458.F50 plasmid Plas1, complete sequence) position: , mismatch: 4, identity: 0.913

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctgcctgctgcctgctgcctgccgcctgctgcctgccgcctgcc	Protospacer
.***********************.*************.******.

79. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to MN813049 (Dickeya phage Ds9CZ, complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

80. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to MN788369 (Dickeya phage Ds3CZ, complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

81. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to KY942057 (Dickeya phage XF4, complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

82. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to MN813048 (Dickeya phage Ds5CZ, complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

83. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to HE600015 (Dickeya phage vB_DsoM_LIMEstone1 complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

84. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to MH807812 (Dickeya phage Kamild, complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

85. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to KY942056 (Dickeya phage JA15, complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

86. spacer 19.3|6562601|26|NZ_CP022310|CRT matches to MG266157 (Dickeya phage PP35, complete genome) position: , mismatch: 5, identity: 0.808

ccgacgcccagaatcttcatgactgc	CRISPR spacer
agaacgcccaggatcttcatgacttc	Protospacer
  .********.************ *

87. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022766 (Ralstonia solanacearum strain T78 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

88. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022482 (Ralstonia solanacearum strain HA4-1 plasmid HA4-1MP, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

89. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052111 (Ralstonia solanacearum strain FJAT15244.F50 plasmid Plas1, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

90. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052113 (Ralstonia solanacearum strain FJAT15244.F1 plasmid Plas1, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

91. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022769 (Ralstonia solanacearum strain T60 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

92. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022779 (Ralstonia solanacearum strain SL3882 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

93. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022793 (Ralstonia solanacearum strain SL2729 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

94. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022787 (Ralstonia solanacearum strain SL3300 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

95. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP021449 (Ralstonia solanacearum strain SEPPX05 plasmid pSEPPX05, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

96. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022773 (Ralstonia solanacearum strain T42 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

97. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022785 (Ralstonia solanacearum strain SL3730 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

98. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022756 (Ralstonia solanacearum strain T117 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.891

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
.***.  .**************************************

99. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 5, identity: 0.891

--tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cctccggcccg--gcctgctgcctgctgcctgctgcctgctgcctgct	Protospacer
  * * ***.*  ***********************************

100. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP025960 (Rhodococcus qingshengii strain djl-6-2 plasmid pDJL1, complete sequence) position: , mismatch: 6, identity: 0.824

---gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ccggttctg---ccggctgctccggctccggttccgg	Protospacer
   **** *   ***** ****************** 

101. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022791 (Ralstonia solanacearum strain SL3103 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.87

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
.***.  .*************************************.

102. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022781 (Ralstonia solanacearum strain SL3822 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.87

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgctgcctgcc	Protospacer
.***.  .*************************************.

103. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP015205 (Rhodococcus sp. 008 plasmid pR8C2, complete sequence) position: , mismatch: 7, identity: 0.794

---gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ccggctctg---ccggctgctccggctccggttccgg	Protospacer
   *.** *   ***** ****************** 

104. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.794

gttcg-gtgaccggcggctccggctccggttccgc	CRISPR spacer
-tgcgcacgccctgcggctccggctccggctccgc	Protospacer
 * ** ..* ** ****************.*****

105. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP017300 (Rhodococcus sp. YL-1 plasmid pYLC1, complete sequence) position: , mismatch: 7, identity: 0.794

---gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ccggttctg---ccggctgctccggctccggctccgg	Protospacer
   **** *   ***** *************.**** 

106. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NC_022125 (Rhodococcus erythropolis CCM2595 plasmid pRECF1, complete sequence) position: , mismatch: 7, identity: 0.794

---gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ccggttctg---ccggctgctccggctccggctccgg	Protospacer
   **** *   ***** *************.**** 

107. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP011297 (Rhodococcus erythropolis strain BG43 plasmid pRLLBG43, complete sequence) position: , mismatch: 7, identity: 0.794

---gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ccggttctg---ccggctgctccggctccggctccgg	Protospacer
   **** *   ***** *************.**** 

108. spacer 17.1|5824970|33|NZ_CP022310|CRISPRCasFinder matches to NZ_CP027239 (Dietzia sp. oral taxon 368 strain W5195 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.788

tggccgttgcgtggggcgggcggtgagcacagc	CRISPR spacer
gagcaggcgcgcggcgcgggcggtgagcacagc	Protospacer
 .** * .***.** ******************

109. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
tgctgcctgctgcctgctgcctgctgcctgcttgctgaggaccgcg	Protospacer
********************************  ***  * *.** 

110. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP016555 (Ralstonia solanacearum FJAT-1458 plasmid plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

111. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP015851 (Ralstonia solanacearum strain YC40-M plasmid, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.***.  .******************************.******.

112. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052071 (Ralstonia solanacearum strain FJAT454.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

113. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052075 (Ralstonia solanacearum strain FJAT448.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

114. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052105 (Ralstonia solanacearum strain FJAT15252.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

115. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052077 (Ralstonia solanacearum strain FJAT445.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.***.  .******************************.******.

116. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052115 (Ralstonia solanacearum strain FJAT1463.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

117. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052079 (Ralstonia solanacearum strain FJAT445.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.***.  .******************************.******.

118. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052107 (Ralstonia solanacearum strain FJAT15249.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

119. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052117 (Ralstonia solanacearum strain FJAT1463.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

120. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052125 (Ralstonia solanacearum strain FJAT1452.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.***.  .******************************.******.

121. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052121 (Ralstonia solanacearum strain FJAT1458.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

122. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052123 (Ralstonia solanacearum strain FJAT1452.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.***.  .******************************.******.

123. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052073 (Ralstonia solanacearum strain FJAT448.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

124. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052081 (Ralstonia solanacearum strain FJAT442.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.***.  .******************************.******.

125. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052083 (Ralstonia solanacearum strain FJAT442.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgcctgcc	Protospacer
.***.  .******************************.******.

126. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052109 (Ralstonia solanacearum strain FJAT15249.F1 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

127. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052103 (Ralstonia solanacearum strain FJAT15252.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

128. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052119 (Ralstonia solanacearum strain FJAT1458.F50 plasmid Plas1, complete sequence) position: , mismatch: 7, identity: 0.848

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgctgcctgcc	Protospacer
.***.  .***********************.*************.

129. spacer 1.1|918429|33|NZ_CP022310|CRISPRCasFinder matches to NZ_CP045385 (Ruegeria sp. THAF33 plasmid pTHAF33_a, complete sequence) position: , mismatch: 8, identity: 0.758

tggtgcgggccgccgaggttcggtggttcggga	CRISPR spacer
caattcgggccgtcgaggtccggtggttctgca	Protospacer
...* *******.******.********* * *

130. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP022999 (Rhizobium sp. 11515TR strain 10195 plasmid p11515TR-A, complete sequence) position: , mismatch: 8, identity: 0.765

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
cctatgtctccggcggctccagttccggttccgc	Protospacer
 .*  **  ***********.*.***********

131. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP040763 (Paracoccus sp. 2251 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.765

-gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
cggcccgcg-ccggcggccccggctccggtcccgg	Protospacer
 * .* *.* ********.***********.*** 

132. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP049788 (Ralstonia solanacearum strain B2 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

133. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP016905 (Ralstonia solanacearum strain KACC 10709 plasmid unnamed1) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

134. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052095 (Ralstonia solanacearum strain FJAT15340.F1 plasmid Plas1, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

135. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052097 (Ralstonia solanacearum strain FJAT15304.F6 plasmid Plas1, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

136. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052093 (Ralstonia solanacearum strain FJAT15340.F50 plasmid Plas1, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

137. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052101 (Ralstonia solanacearum strain FJAT15304.F1 plasmid Plas1, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

138. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052099 (Ralstonia solanacearum strain FJAT15304.F50 plasmid Plas1, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

139. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052129 (Ralstonia solanacearum strain FJAT1303.F1 plasmid Plas1, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

140. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP052091 (Ralstonia solanacearum strain FJAT15340.F6 plasmid Plas1, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgccgcctgccgcctgcc	Protospacer
.***.  .***********************.******.******.

141. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP021763 (Ralstonia pseudosolanacearum strain RS 476 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgccttca	Protospacer
.***.  .******************************.**** * 

142. spacer 21.1|6978804|46|NZ_CP022310|CRISPRCasFinder matches to NZ_CP021765 (Ralstonia pseudosolanacearum strain CRMRs218 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.826

tgctgcctgctgcctgctgcctgctgcctgctgcctgctgcctgct	CRISPR spacer
cgctaggcgctgcctgctgcctgctgcctgctgcctgccgccttca	Protospacer
.***.  .******************************.**** * 

143. spacer 11.1|4111955|37|NZ_CP022310|CRISPRCasFinder matches to NZ_CP017427 (Methylobacterium sp. XJLW plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.757

ccgcgcccgccatgttctgcacgaggcgggacacggc	CRISPR spacer
ccgcgcccgccatgttcggcacgacgcttcgatccgc	Protospacer
***************** ****** **   .  * **

144. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP013069 (Pannonibacter phragmitetus strain 31801 plasmid p.p-1, complete sequence) position: , mismatch: 9, identity: 0.735

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
tgtcggtgatcggcggttccggctccggcaagtc	Protospacer
  *******.******.***********.    *

145. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP032313 (Pannonibacter phragmitetus BB plasmid p.BB_1, complete sequence) position: , mismatch: 9, identity: 0.735

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
tgtcggtgatcggcggttccggctccggcaagtc	Protospacer
  *******.******.***********.    *

146. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP013744 (Streptomyces sp. CdTB01 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.735

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
tggcggcgaccggcagctccggctccggcgcggg	Protospacer
   ***.*******.*************. * * 

147. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP033508 (Mesorhizobium jarvisii strain ATCC 700743 plasmid pMJ700743a, complete sequence) position: , mismatch: 9, identity: 0.735

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
cttcgctgaccggcggcttcggctcggcgctcgg	Protospacer
 **** ************.****** *  ..** 

148. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP033369 (Mesorhizobium loti strain SU343 plasmid pMLSU343a, complete sequence) position: , mismatch: 9, identity: 0.735

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
cttcgctgaccggcggcttcggctcggcgctcgg	Protospacer
 **** ************.****** *  ..** 

149. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to MK686069 (Streptomyces phage Heather, complete genome) position: , mismatch: 9, identity: 0.735

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
gtcgctcgttcgccggctccggctccggctccgc	Protospacer
**.   .* .** ***************.*****

150. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to MH744418 (Streptomyces phage JustBecause, complete genome) position: , mismatch: 10, identity: 0.706

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ccacggtgatcggcggctccggttccggggagga	Protospacer
 . ******.************.*****    * 

151. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to MT310898 (Streptomyces phage Kela, complete genome) position: , mismatch: 10, identity: 0.706

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ccacggtgatcggcggctccggttccggggagga	Protospacer
 . ******.************.*****    * 

152. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to KY676784 (Streptomyces phage ToastyFinz, complete genome) position: , mismatch: 10, identity: 0.706

gttcggt--gaccggcggctccggctccggttccgc	CRISPR spacer
--ccagccgcacccgcggccccggctccggttcctg	Protospacer
  .*.*.   *** *****.**************  

153. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to CP054921 (Streptomyces sp. NA03103 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.676

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
cgagggtgaccggcagctccggcgccggggagtc	Protospacer
    **********.******** ****     *

154. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to NZ_CP054617 (Azospirillum oryzae strain KACC 14407 plasmid unnamed3, complete sequence) position: , mismatch: 11, identity: 0.676

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
tcggggtggtcggcggctccggctccggcaaatc	Protospacer
 .  ****..******************.    *

155. spacer 14.1|4933372|34|NZ_CP022310|CRISPRCasFinder matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 11, identity: 0.676

gttcggtgaccggcggctccggctccggttccgc	CRISPR spacer
ggctcaccgccgccggctccggctccggctccgg	Protospacer
* .. .. .*** ***************.**** 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	3780242 : 3822263	41	Streptomyces_phage(37.5%)	integrase,plate,tail	attL 3805110:3805157|attR 3822343:3822390

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP022310|3780242:3822263|DBSCAN-SWA
CATGCCGACGTACCTCACCCCGGGCGTGTACGTGGAGGAGGTGCAGTCCGGTGCCCGACCGATCGAAGGGGTCGGCACCGCCGTCGCCGCGTTCGTCGGTTTCGCGGAGACCGGCCCGTTCCACACGCCGACGCTGGTGACCAGCTGGGACCAGTACACCCAGCTGTTCGGTGGCTTCACCGAGGGCACCTATCTGCCCCTGGCGGTCTACGGGTACTTCGCCAACGGCGGCGGCGCCGCCTACATCGTGCGGATCGGCGGTTCCGCCGACGACGCCTCCGCCCCGGCGGCGGGTGCCGGCCGGCGGCGCGGGGCCAAGGCGGCGCAGCCGGTGGAGCTGGGCGGCTTCCTGGTCGCGGCCCGGCCGGGCGTCTCCGGCGTGTCGGTGGAGATCGCCGACGCGGACGGCGAGAACCCGCCGGAGGACCGCTTCAAGGTGGTGGTCCGCCAGGGCGACCAGGTGGCGGAGACGTACGAGGTCTCCACCCGCAAGAACGTCAAGGGGTACCTGGTCGGCCAGGCCCGTGCCTCCAAGCTGATCGAGGTCACCGAGCAGCAGGGCGCCGCGCAGAGCAGGCCCGCCAACCAGACGGTGACGCTGGCCGACGCGCCGGCCGCGCCCGCCGCTCCCGGCTCCGGCGAGGTGGCCCGCCTCGACCCGTCCGAGTACGTCGGTGACGCCGGGGCGCGTACCGGGTTCGGCGGTCTGGAGACCATCGACGAGATCACCATGGTTGCGGTGCCGGACCTGATGAGCGCCTACCAGCGCGGCGACATCGACGCCGAGGGCGTGCGCACCGTGCAGCTGGCGGTGATCTCGCACTGCGAGCAGATGGGCGACCGCGTGGCCGTGCTGGACACCCCGCCCGGCCTGACCGCCCAGCAGGCGCGTACCTGGCGCAACGACGAGGCGGGCTACGACTCCCGGTACGCCGCCCTGTACTACCCGTGGGTGCGGGTCTTCGACCCGGCCGTCGGACGCAACACGACCGTCCCGCCGAGCGGTCACATCGCCGGTGTGTGGGCGCGCAGCGACGCCGAGCGCGGTGTGCACAAGGCGCCCGCCAACGAGGTGATCCGCGGTGCGGTGGACCTGGAGATCCGGCTCAGCAAGGGCGAGCAGGACCTGCTGAACCCGATCGGCGTGAACTGCGTACGGGCCTTCCCCGGCCGGGGCATCCGGGTGTGGGGCGCCCGCACCCTCTCCTCCGACCCGGCCTGGCGCTACCTGAACGTGCGCCGCCTGTTCAACTACCTGGAGGAGTCGATCCTCCTGGGCACCCAGTGGGTGGTCTTCGAGCCGAACGACGACCGGCTCTGGTCGAGCATCCGGCGCAACGTCACGGCGTTCCTCACCGAGGAGTGGCGCCGGGGCGCGCTGTTCGGCCGCACCGCCGAGGAGGCGTTCTACGTGAAGTGCGACCGCGACAACAATCCGCAGGAGTCCATCGACCAGGGCCGGGTCGTCTGCGAGATCGGTGTCTCGCCGGTCAAGCCCGCGGAGTTCGTGGTGTTCCGGCTGGCCCAGTTCTCCGACAGCACCAGCCTCATCGACGAGTGACCCGCGGGGTCGGCAAGGAAAGGTGACGGACAGTCATGGCAACGGGCGATGCTCTTTCCACCCATATCTTCGGCGTGCAGCTCGGCGGCTACCTGGTCGAATCGATCCAGGAGATCAGCGGGCTGACCGTCGAGGAGGACGTCGTCGAGGTCAAGCAGGTCACCGCCGAGGGCAAGCGGATCATCCGCAAGCAGCCCGGCGGCCGGCAGGCGGGCGAGATCACGATCACCCGGGGACTCGACCAGAGCAGCGAGTTCACCAACTGGATCAAGGAGACGCTGAACAACGGCGCCGTGAACACCGCGCGCCAGAACCTCACCATCGAGATCAAGGACACCGAGGGCAACACGGTGCGCCGCATCCAGCTGATGCAGGGCTGGGCCTCCAAGTGGGAGGGGCCGTCGCTGCAGGCGGGCGAGTCGTCCGCGGCCACCGAGACCGTCACCATCGTGTTCGAGGAGATCGTCGTCGAATGAGGCGCCGAACGGTGACGGCGGGCAACCTGGACGAGATCCTCCAGGCGACGGCGCCCGCCCCGGCGGCCGAGCAGCCGGCACCGCCCCGTGCCGCCGCCGCGCCGCCGGCACGGGAGGACCACGGGCTGCGCACGGAGTTCGAGTTCGAGCTGCCGCGCGGGTACGTCGACGAGGCGGGCACGGTGCACCGGCACGGCGCGATGCGCCTGGCCACGGCCCGGGACGAGCTGCGGCCCCAGATCGACCTCAGGGTGAAGGAGAACCCGGCGTACCTGAGCGTGGTGCTGCTGAGCCAGGTGATCACCCGGATCGGCTCCATCACCGACGTGCACGCCGGGATCGTCGAGCGGATGTACGCCACCGACGTCGCGTTCCTCCAGGACTTCTACCGCCGCGTCAACAGCGAGGGGCACACCCGGGCGGCGGTGACCTGCCCGCACTGCGAGGGCGGCTTCGAGGTCGACCTCTCGGGTGGGCGCCTGGGGGAATCGTGACGTACGCGCTTCCCCGGCTCCGGGAGGAGATCGCGTACGTCGCCTACCACTTCCACTGGCCGCGCGAGGAGATCCTCGACCTGACCCACGACGAACGCCGGCAGTGGGTGGCCGAGATCGCCCGCATCAACACCCGTGTGAACGAAGGTGGCTGAGCGCATGGCATGGCGGGACAGACTGCGCCGCCGGGCCGCCCGGCACCGGGACACGCCCGGTGCCGGCGGGCCGGGCGGAGGCGACGGCCCGTCCGGCGGCGGCCCCGGACCGAGCGCGCCCGACGCTGCGGCTCCTTCCGTGCCCGCCGACTGGGACGGCGGCTGGCGCCGTGCCCCGGCGCCGGTGCTCACCGTCTCCCGGGCCCCGCTCGGCGTCAGCGACGGCCTCGCCTTCAGGGCGGGGCTCGCCGCCTGGCAGGACCCGTCGTTCGACGCCGGCCTCGGTCACGCCCTGCTGCCCACGGCCCCGACCGGCCTGGTGCGCGGCGTCACCCGCCCGGCCACCCCGCGGGCCGGCCGCAGCAGCGGGGGACCGCTGCTGCTCCGGTCACTGCGGCCGACGGGAGCGGACGGGGCGCAGGAGGCGGACGGGGCACAGGGCGGTGCGCCGCGCGCCGGTGCGGCGTCGTCCGGTACGCGGTCGTCCGGTTCGGCGTCGTCCGGGTCGGTGCCGTCCGGTACGCGGTCATCCGGTGGGGCGTCGTCCGGTGCCGTGCCGTCCGGTAGGGCGTCGTCCGCTGCCGTGCCGTCCGGTTCGGAGCCCGTGGTGGCGCGTCCCGGTGGGGACGGTGCTGCGGGGAGGGGACGTTCGGGCGACGTCCCGCGGAGCCGTGGCCTCACGTCCGTGGAATCTCCCGCCGTACTGTCCGCCTCTCCCTCTCCCTCTCCCTCTCCCTCTACCTCTTCCTCACCGTCCGTCGCCCAGCGTGCGGTGGAGCCCGGCACCGGCCGCCCGCCTGCCGTACCGGAGATCCCGCTGGTGCGGCGAGTGGCGGTGGTCCCTGGCACGGCCGCGGACCGGACCGCGGTCGGCGGGCCCACCGCAGGCACGCGGTCGGGCCCGCTCGAACCGGCCTCCGGACGCGCCTCCCGGCCCCCGTCCGGTACCGGGAGGCGTACGCCTTCCGGCCCGGACACCCGGCGCACCGCGGCCGGCACGACCGGGCCTCGGCCCTCCCGGGACGGCGGGCCGCCGGAGGCGTCCCGGGCCTCCGGCGCCGACGTGTCCCCACCGTCCGCCCGGCTCCGCCCGGCAGGGCCGTCCCTGACCGTCGCCCGCCGCCCGGCCGGACCGGTGCGCCGCGTCCCCGCCCTGCGCCCCACCACCGTCCAGAACCCCGCCGGCCCCTCCTCGACACCCGCACCGACCGCACCGACCGCGGGCTCGACCACCGCCGCGCAAGCCTCGACCACCGCCGTGCAGCGCTCGGCAACCTCCGCGCCGGGCCCGGCCACCCGCGCGCCGCTCGGCACCCCGCTGAGTGAACTGCCCACCACCGCGGTCCCGTTGGCGAAGGACGCCCCGATCCCGCACCCCGCGCCCGGCGCCGCGGCCGGTCCGGCTCTTCCTGTCGTCCAGCGCCGCGCGGAGGGCACGACCGGCACCGAGGGCTCGCACGACGGCAGGGCGGGCCGAACGGCCCACGGCGGCACCCCGGACGGCCCCGCCGCACCGCCCGGCACTCCGCGCCGGACCTCCGCCCGCACCGGGGCACGCGCCCGTGGCGGGCTGGGCGCGCCGCTGCCCGCGCTGCCGGCGAGCGCCGACCTGCAAGGCCCCGCAGCCTCGGGCCCGAAGGCCCCGCGGGCTCCCGCACGACGGGACCGGTCGGCCGACGCCGCTCCCGTACGACAGGACCGGGGAACGGACGCCGCTCCCGTACGACAGGACCGGGGAGCCCACGCCGTTCCCGTGCCGCCCACGACGGAGCGCAGGCGCACGTCCGCCGAGGCCGCGTCCCGTGCGGCGGGCGGGAGCGGTGCGGACGCACCGCTGCTGGGGACGGCGGACGTGCAGCGCCGCCCCGCAATCGGCTCGTCCGACGCGAGCACCTCGCAGCAGCCCGGCCCCGCGCCCCACGAGAACGGGCCCGCGACGCCCTTGGTGACGCCGTCCCCGGCCACCGCGCCGCAGGGCCCGGTACCGGCCGCCGCCGCAGGCCATGAGGGCGCACGACGGACCGGCACGCTGTCCGGCGGCGGACCGGGCTCACAAGGGCAGCGGCACCGGTCCCCCGCCGCCACCATGGGCCCGCTCGTCGTCGCCCGGCGCGTCACCGAAGACACGTCAGGCACGTCAGGCACGTCAGGCACGTCGGGTCCGTCGGGTCCGTCAAGCGTCTCGGGCGCCCGGCCCTTCGGCCCGGCCGGCCCGGACCCGCTCACGGTCGCCCGCTCGGGGGCGCACTCCGCTTCGACGGCACCGCGCACCCTCTCCCTGCTCGCCGCGCGCCCGCTCGCCCTCAGCACCCGGCCCCCGGAAGGCGCGGCACCGCCTGCCGTGCGCGCCACCGGCCGTCCGGTGGTCGCGGCGCGCTGGCCCGCCCACCCGGTCGCCACCCGCACCGACCCGCCCCACCCCACGACCACCCGCCCCGACGCACCGGCCACCCCACGGAACCGGAACGACCCCGCGCCGCCCACCCGCCGCCCCGCGCGACCGGAACCGGCCCGGCCCGCGGCCGCCCCGGCGACGCCGTGGATCCAGCGGGCCACGGCCGACCACCCCGGACCGCAGGACCCGGGCGTACGAACCACCGGCCCCGCCGCCTCCGTTCAGCGTGTCCCGGTCGTCCGGCCCGCACCGCCCCACCCGGGAACATCCGGGCCCGGGGCCGCCCCGTCCGCCGCCGTACCGGCACGGCCGCTGCCGGTGACCGCCCCGCAGGCACCGCCGCTCGCGGACCGCCCGCCGGTCGCGCCGGCACCGGTCACGGCGGGTGCCGTCCCCGTGGTCCGACGCCGGAGCGCCGCGCTCGGCGGTGCGACCGGCCGGGAGGCGCCACCGGTGCAGCGCACCGGCGGCGGCGACCGCGTACCACCGGGCGTGCCCGCCAAGGCCGTACCGGCGCGCGCCCGCCCGCAGTCGACGCCCGGGTTCGCGTCCGCGTCGGCCACGGCGTCGGCGTCCGGCAGGAGCGCGGACCGGCGCGGCGAGCCGGCACCGGATCCCGGCCCCGACCTGGACGACCTGGCGCGCCGCCTGCTCGACCCGGTGTCCCGGCTGCTCCGCGCCGAACTGCGGCGCGGCCGGGACCGCACGGGCCGCCCCCACGACGGACGCCGCTGAGGCCATCGACGAAGGCCCGGCCGAGGCCACGGACGAGGCCGCTGGGACCACGGAACGAATGAGGTCAGGAAACGGGTGACGGACCAATGACGGACAGCATCTTCGCGACGAGCGTGTTCTTCCGGCTCGCGATCGGCGGCAACGACCTGGGCGCCTTCCACACCTGTTCCGGCATGGGTGCCGAGGTCGAGATGGAGAGCTACGCCGAGGGCGGCAACAACGGCTTCACCTGGCAGCTGCCCGGGCGCGTGACCTGGTCGAACATCACGCTCACCCGGCCCGTCACCGCCGACACGGCGAAGATCGGCCGCTGGCTCGACGAGACGCTGAAGCGGGTGGAGCCCAAGGACGGCGAGATCGTGGCGCTGAAACCGGACCTGACCCGGATCATCAGCTGGCAGGTGTTCGGGATCGTCCCGGTGCGCTGGCAGGGGCCGTCGTTCGACCCCGCCGGCGCGGAACCGGCGGTGGAGACCCTGGAGATCGCCCACGAGGGCCTGCGCCCGTCCTGACCCGCCCGCCCCAGCCGCCCCGCCACGCGTCCCCGTTCGCAAAGGAGGTCCCGGTATGTCCCCAGCGGTCCGCTCCAGCCGGGCCAGGGCCCAGCTGACCCTGAAGGAACCCCCGGCTTCGGTCGGCGCGAAGCCCGGCGGGACGCTCGCGCGGCTCGACCTGCAGTTCAACCCGTCCACCCTGGAACTGCGCAAGACCACCGAGTGGCGGCGTTCCCCCTCCCGGATGGCGGAGCAGTCGGCGCTGCCCGAGTTCGTTGGCAGCGGCCCGCGCGAGCTGAGCCTGGAGGTGTTCCTGGACGCCACCGCCACCCACGACAACTCCGTGGAACAGGCCGTGGAGAAGCTGATGAAGGCCTGTGTGCCCACCCAGGCCAGCCTGGGCCGCAAGAAGCCGGCCAGCCCCTGGGTGCGGTTCGAGTGGGGCACCGCGCGGACGACCTCGTTCGACGGGGTGCTCTCCAGCCTGTCGGTGACGTACACGCTGTTCGACGTGGACGGCAAGCCGCTGCGGGCCACCTGCGCGCTGTCCATCGAGGAGGCCAGCGTCGACCCGCCGGGCCAGAACCCGACGTCCGGCGCGCGCACCGCCCGCAGCACGCACACCGTGGTGGCGGGCGACAGCCTGGCCCTGCTGGCCTGGCGGGAGTACGGCGACGCGACGGCCTGGCGGGTCATCGCGGAGGCGAACGCGGTCGACGACCCGATGGCGCTCGCGCCCGGCACCGAACTGGTGGTGCCGGGACTGCGGGACGCGGGCGGTGAGGAGGAGCGGTGACCACATCCGAGGGGCGGGGCGGCCGGTCGTTCGCCGCGGACCCCGTCATCGAGGCGCCCGCCGAGCTTCCGCCGGTCTGGGCCGCCCAGCTGGTGAGCTGCGTGGTGGACGAGAACGTGGGCCTGCCCGACGCGGCGGTGCTCACCTTCCGCGACCCCGACCACGAGTTCCTGACGGCGACCGGCATCACCATCGGCACCCCGCTCAGGGTGTCGGTGGTGACCGTGTCCGGGCAGGCCCGCGAGCGGCTCTTCGACGGCGAGGTGACGGCCCTGGAGGTGGACCGGGACCGCACGGGCTCCTTCACGGTGGTGCGCGCCTACTCCAAGGCGCACCGCCTCCAGCGGGGCCGGAAGGTGGTGGCGTACCGGAACATGACGGCGGCGGCGATCGTCCGCAAGGTCGCCGCCGGGGCCGGGCTGACCTGCGGGACCGTGGAGGCCGCGCCGGTCACCTACAAGCAGCTCTCGCAGGCGAACGTGTCCGACTGGGACTTCCTGCAGTACCTGGCGGCCCAGAGCGGCGCGCAGGTGCGCGTCGACGACAAGGGGCTGCTGCAGTTCACCCGGCCGAAGAAGGCGTCCGGGGCGCCCGCGCCGTCGACCCCTGCCACCCGGAACCCGATGGTGCTGGAGTACGGGCGGAACCTGCTGGCGCTGCGCGCCGCGCTGTCGGCCGCGGCCGGCGCGTCGCAGGTGGAGGTGCGCGGCTGGGACGTCACCACGAAGCGGCCGCTGGTGGCCCGGCAGCCGTCCGTGGACAGCGACACGGTGGTGCCGGGCCTGAGCCCGGCGTTCGCCGCCCGGTTCGGCAGCTCGGCGAAGCTGACCGTCACGGACACCCCGTACCGCACCCAGGCGGAGACGACGGCGGTCGCGGACGCGGCGGCGGCCCAGGTGAGCGCGGCCTTCGGAGAGCTGGAAGCGGTGGCGGAGGGCAACCCCCGGCTGCGGGCGGGCAAACCGGTGGCGCTGGGCAACGTCGGGCGGGCGTTCTCCGGCAAGTACACGGCGACGGCCGTGCAGCACGTCCTGGAGCCGCACCGCGGGTACCGGACGACGGTGTGGGTGAGCGCCGACCCGGACCGCTCCCTGACGGGCCTGGTGACCGGCGCCGACGCGCCGGGCCGCGGGCCGCGCATGCCGGGCCTGGCGATCGGCGTGGTGACGGACGTCCGCGAGCCGGGCGGCGCCGAGAGCGGCGCGGTGAAGCTGAGGTTCCCCTGGCTGGACGACACGTACACCACCGACTGGGTGCGCACCGTGCAGTGGGGCGGCAAGGGCGGCGGAGGCGTGGTGAGCCCCGAGGTCAACGACGAGGTCCTGGTCGGCTTCGAACAGGGCCTGCTGGACAGCCCGTACGTCATCGGAGGGCTCTACAACGGCGTCGACAAGCCGTCGCCGCACGACGTTCCGCTGATCGACGGCACGACCGGCCGGGTCAACCGCCGTTCCGTCGTGTCCCGTTCGGGACACCGGGTGGAGCTGCTGGACGCGAGGGCGCCGGGCCCGTCCGGTGTCAGGCTCACCACCGGCGACGAACGCCTCGAAGTGTTCCTGGACGACCGGCGGGACCGCATCGAGCTGACGGTGTACGCCAAGGGCCGGAGCCCGCTCACCTCGGTCACGCTCGACGGACAGGGCATCACCCTGGACGCGGGACGCGGCGACGTGAGCGTGTCCGGCCGGAACGTGGACATCCAGGGCCAGGTCGGCGTGAAGGTCGGCGGCCGTTCGGTGAGCGTCACCGGCAGCACGGACGTCACCGTCGACGGCGGCCTGCTGGGCGTCCTGAAGGCCAGGCTCGTCCGGATCAACTGACCGCCGCCCAGCCGGATCGACCGACCCGCCGCATCCGACGACCCGCCTCAACCGACGACCCGCCGCATCCGACCCCCCTCATCCGACCCGCCTCATCCGACGACCCGCCTCATCCGATCGACCGACCCGAGCCCGTCCGGATCGACCGAACCCGACTCTTCCGAGGAGCAACGCATGCCGGCCGCAGCCCGTACCGGTGACCCCACCGACCACGGCGGTGTGATCGCCACCCCGCCGCCCGGCGCCGCCGCGGCCGTGGCCCGCGTGCTCATCGGCGGCCGCCCCGCCGCCGTCACGGGCAGCCAGCACGCCTGCGCGATGCCGCCGCACGCCGCCACCGGCCCGGCCAACGTGATCCTGCCCAACCCGGCCGCGGCGGTCGCCGGGGCCGTCCTGATCGGCGGACTGCCGGCCGCGCGGGCCCGCGACCGGACCGCGTGCGGCGCGACGATCCTGACCGGCGCCCCGAACGTCCTGATCGGGGGCCTGTGATGAGCGAGCGGTTCATCGGGCGCGGCTGGGCGTTCCCGCTGCGGGTCGGGCCGACCGGCGGGATCGCCATGGTCGAACGGGAGCGGGAGATCGAGGAGGCGATCCGCCTGGTGCTCGGCACCGCGCCCGGCGAACGCCCTATGCGGCCCGAGTTCGGCTGCGGCATCCACGACTACGTCTTCGCCCCCGGCGACGGCGCCACCGCCGGACGCATCGCACAGCAGGTGCGCGAGGCCCTCGAACGGTGGGAGCCGCGCGTCGCCGTGGACGACGTGGTCGTCGCCTTCGACGCCGTCGAGGACGGCACCCTCTACATCGACGTGCACTACACCGTGCGCTCCACCAACGACCGGCGCAACCTGGTCTTCCCCTTCTACACGATCCCCTCCGAACCGGGCGCCGAGGACGGAGGCGCGGACTGATGGCCCTGCCCTCCCCGAACCTGGACGACCGGCGGTTCCAGCAACTCGTCGACGAGGCGAAGCGGTACGTGCAGCAGCGTGCACCGGAGTGGACCGACCACAACGTCTCCGACCCGGGCGTCACCCTCATCGAGACGTTCGCGTACCTCGTGGACCAGTTGCTGTACCGGCTGAACCGGGTCCCGGACAAGAACTACACCGCGTTCCTCGACCTGCTGGGCATCCGTCTCTTCCCGCCGGCCGCGGCCGGCGCCGAGGTCGACTTCTGGCTGTCGGCGCCGCAGCCCGACACGGTGGCGCTGCCCGCGGGCACGGAGGTGACCACCGCGGGCGGTGAGACCGACGAGACCGTGGTGTTCGCGACCACCCGCCAACTGGACATTCTTCCCTCCGAGTTGACGCGCCTGGTGACCGCGTACCGCACCGGTGAGCAGACCGACCGGACCGGGACGCTCGCCGAGGGCCGCGACATCCCGTGCTTCCAGGCGGCGCCGGAGCCGGGTGACGCGCTGCTGTTCGGCCTGCCGACGGCGGTGCCCGGCTGCATCGTCGCCGTGCGCCTGGACAGCCGGGTGGAAGGCGTCGGCGTGGACCCGCGCCAGCCGCCGCTCGTCTGGGAGGCGTGGGACGGCGGCGGTTGGCGGGTGTGCGAGACCGGCGAGGACACCACCGGCGGGCTGAACCGTCCCGGCGAGGTCGTCGTGTACGTACCGGCCGGGCACACGGCGTCGGTGATCGGCGGGACGCGCGCCGGCTGGCTGCGCTGCCGCGTCACCGAGGCGGAGCCGGGCCAGCCGTTCTACTCGGAGTCGCCGACGGTGCGCGAGGCGGCGGTGTTCACCGTGGGCGGCACCATGTCCGTGGAGCACGCCGAGACCGTGACCGACGTACCGCTCGGCACCTCCGAGGGCGTCGCGGGACAGACGTTCCGGCTCGGCCGCCCGCCCGTCCTCCTCGACGGCGAGCCGCCCGTGGTGGAGGTGTCCTCCGCCGACGGCTGGCAACGCTGGGAGGTGGTCGAGCACTTCGGCCGCTCCGGCCCCGACGACCGGCACGTCCGCGTGGACGCCACCACCGGCGAGTTCGCCTTCCCGCCGGTGCTGCGCGAACCGGACGGCACCCTGCGGCAGTGCGGTGCCGTCCCGCCCAAGGGCGCACAGGTGCGGGTGGCCCGCTACCGCACCGGCGGCGGCCCGGCCGGCAACGTCGCCCGTGGCGCGATCTCCGTGCTGCGCAGCTCCGTCCCGTACGTCGCCCGCGTCACCAACCGGGAGGCGGCGCGCGGGGGTGTCGCCGGGGAGACCGTCGAGAACGCCAAGCTGCGGGCCCCGCAGGCACTGCGGATGCAGGAACGCGCGGTGACCGCCGAGGACTACGAGATCATCAGCCGCCGGGCGGCGCCCTCGGTGCGCCGGGTCCGCTGCCTGCCCGCCGCGGACGGCGCGGGCGCGGTACGGGTCCTGGTGGTGCCGGACGCGGTGGCCGACGAGGGCGACGACCGGCTCCGCTTCGAGCAGCTGATCCCCTCGGACCAGGTCCTCGAAGCGATCACCGCGAGCCTCGACGAGCGGCGCCTGATCGGCACCCGTGTGGTGGTGGAGCCGCCGGTCTACCAGGGCGTCACCGTGGTGGCCCGGCTGCTGGCGGCGCCGGGCGACACCGACGCGGTGCGCGAGGCGGCGCTCGACGCGCTGTTCCGGCACCTCAACCCGCTGCACGGCGGCCCGGACGGCCGCGGCTGGCCGTTCGGGCGGCCGGTGCAGTACGGGGAGGTGTTCGGTGTGCTGCAACGCGCCGGCGGCAACGCGCTCGTGGAGGAGATCCGCCTCTTCCCCGCCGACCCGATCACCGGCCGGCGCGGCGCGCCGACCGACCGCATCGACGTGGCGCCGGGCGCACTGGTCTTCTCCTACCAGCACCAGGTGGTCGTCACGGCGACCGAGCCGGGAACCGGGGGAGAGGTACGGGGATGAGCGTCGCCGACACCGCCGTGGAAGCGGAGGCACGACGATGAGCCGCGCCGCCGTGCCCGGCCTGCCGAGCAGGCACCCGATCGGCGAGCAACTGCCCGCCGTGTACGCCGACGACGACTTCGCGCAGCGGTTCACCGCCGGCCTCGACACCGTCCTCGCTCCCGTCTTCGCGACCCTGGACAACCTGGCCGCCTACCTCGACCCGCGGGTGACCCCGGCCGACTTCCTGGCCTGGCTGGCGTCGTGGGTGGGCGCCGCCGACGACCCGCGGCGGCCGGTGGAACTGCGCCGCGAGGCCGTCGTCCGCGCGGTGGAGCTGCACCGGTGGCGCGGCACCGGCCGCGGCCTGGTCGAGGGCCTGCGGCTGGCGCTCGGCGTGCACGCGGAGGTGACCGGGGACGGCGGCGCGGTGTGGTCGAGCACCCCCGGCGCCGACCTGCCACCACCGTCCACCACCGGGCCCGTGGTCCGCGTGTGGCCCGGCCGCGAGGCACGGGTCGACCCGGACAGGGTCCACGCGATCGTCCGCGCCATGTGCCCGGTGCACACCGTCTGCCGGGTGGAGATCCTGCCCGGCCCGCCCGCCGACGAAGGGAGGTGACGCCGTGCGCGCGTGTCCCTCGTGCGGGGCGTCCAACGACCCCACAGACGACTTCTGCGGCAACTGCGGCGCGTACCTCGGCTGGTCGGACTCGAGCCCCGCCCCGAGCACGCCCCCGCAGCCCTCCACGCCCACCCCGGCGGACGAGTCGACGCCCGCCGCACCTCCCGAGGCCGGTGAGGCGGGCGCCGCGCCTGCCGACGGCTCACCCTCCGGCGACCCCGAGAAACCCGCCACCGGTCGCCCCGACCCCACGAGCGCCCCGCCCCGGGCCACCCCGGCCGCCACCCGCACCGACCGCCCCGCACCCGGCTCCGCTGCCCCCGGCCCCGCAACACCTCCCCCCACCCGGCCCCCACACCCCACCGGCCCCGATCCTGCCGCCGCATCCGGAACGAGCGCACGACCCCCCGGGCCCCCGCCGGCACCCTCGGCCCGCACCCCCGCCGCCCCGACACCGGACCCGGTGCTGCCCGTACGCCCGGCGAAGCCGGTGGCCCCGCGTCCCGTCGTACGACCGGCAGCGGCGGTGCCGGACGAAGGGGCGGGCGTGCCGTGTCCCGCCTGCGGCGCGCTCAACGCGCCGGGCCGCCGCTTCTGCCGGCGCTGTGCGACCGCGCTGAACCCCGCCCCGAAGGCCGCTCCGCTGCCGTGGTGGCGGACCGTGTGGCCGCTGCGCCGCCGGGTGCGGGCCGGATCGGGCCGCGCGGTGCGCCTCCTGGTGATCCTGGCCGTGCTGGCGGCGCTGTGCGTCGGCGGCGTCTGGCTGCTGCCCGCCGGACGCGCCCTGGTCGAGGACACCCGGGACAAGTTGAGCAAGCCGAAGCCCGTGACGCCCGTGTCCGTCGAAGCGAGCGCCGAGATCCCCCGGCACCCGGCGACGAACACCACGGACGGCCTGAGCAACCGCTACTGGGGCGCGCCGGCGGCGGGCGCCTCGGTGACCTACACCTTCCGCAAACCGTTCCGGCTGATCGACCTGAGCATCATCAACGGCGTGTCCAAGTCGCCGGACCAGTACGACCGTCAGGCCCGCGCGCTCCAACTGGACATGGAAGTGACGACGCAGGACGGAGAACGCCACCACAAGGAACTCGCCCTCGCCGACAAGGCGGGCCCGCAGACGTTCCCCACCGGCATCAGCGACGTGACGTCGATACGCCTGGTCCTCCGCTCACCCGTCGACCTGACCAACGGCCGCCACCTGGCTCTGGCGGAGGTGGAGTTCTTCCAACGCGGCTGACCGGCAACCGTCTCCCACACCACCGTCCCCACCCCCCGTCAGCACCCCGCACCCGCACCACCTCCACCCTCCTCCGGGCCGGCGTGGCGCACACAGGACACCACGACCACGAAGGGCCACAACGACTGAAGGGTCGTCACAAGGCGTTCGGCGACCCCGGGGGCACCCTGACGCTGCATCTCGATCAGGAACCAGGCCGCTCCGACACCCATCACGACGGTCGCCGCGAGCGAGGGCACGGGCCGCAGTCCCCACGGCGCCGCCCCACTGCGGTGCGCGGCCAGCACCGGCCAGACCGCCAGCAGCACGAAGCCGACCACGGCGACGGAACCGTGCCGCAGCGAGCCGCCGCTGCTCGGCGGCGGGAGCAGAGCCACCACCCACGCCACCACTCCGCCGCCGCCCAACGCCACCCGCCCGGCGAACGCGGCCGCCCGCAGCCCCCAGGCGGTCAGCACATGGCAGACCCCCAGGGCGAGCAGCGCTCCGGTCATCACCCAGAACCCCGCCGCCCCGTAGGCCGCCAGGACGCTGATCGTCTGGGTGACGGGGTCGTAGGCGGGCCCTTCGAGAAGCGCCGCGACCGTCCAGCCCGCGATCAACAGGACAGGCGCGCACACCGACGAAAGCAACGCCCACCTGGGCACAGGTCGCACCGACTCACCGTAGAACGCCCGGTATCCCCCACGCCGCCGCCGCGCCCAGCGGGACGTGGCCGCACCCGAGCCGGAGCCGGACGGCATGCCCGGCTCCTGCGGCCGCGCAGCACAAGCGGGCACGGCCGCGCGTGGGACGCCTTGCCGGACGTCCTCCCACCACCGGCGGACACGCCTCAGGACGCAACCGGCCAGGGACCCTTGCGGCCAGCTCTTCACTCTTCCGGCACCCCCGAGGCGCGACGAGAGTGGTTCCCGCCACCGGGCGCCACTCCCGTGAACACCCCGCTCAGCTGCACCTGCAGGGCAGCTGCGCGGGCCAGGGACGTGCGTGCGCCCACTCGACTTCCGTGCCGCAGGAGAAACCGTGAAGCTGAGCAATGCCGTGCGCCGCACGTCCGCCGTCCTCGCCGTCGGAGCGATGTCCCTGGGCCTGGTCACCGTCACGGGCGGGACCGCACAGGCCGTCGCCTCGTGCACCGGTGACGTGTCGATCTACGGCACCCTGTCGGACGGCAGGCTGACGTACACGCAGATCGCACCGAACACCGGCGACCGCCTGAAGACGCTCATCGGCCCCGACCTCGGCTTCACACCGAAGGCGATGGCCACGCTCAACTTCAACACGGTGCTGGTCACCTCGACCACCGGCGACCTCTACCGCGTCGACGTCCAGACCAACAACACGTCCCTCGGCCTCGCCGGGGTCGTCAAGATCTGGGACGGCGGCTGGACCTTCGACAAGATGGTCTACGACGGCGCCGGCCACCTCTACGGCACGGTCGACGGACAGCTCCACCAGTACCTGGTGTCGCAGGACAAGCCCGCCGGGTCCGCCCACATAGGTCAGCACGTCGTGATCGACACGGGCTTCGTCCTGAGGACCCTGGCCGCTGCGGGCGACGACCGCATCATCGCCTCCACCTCGGACGGACGCCTGCTCAGCTACAAGATCAACGGCGTGAACGACTGGGACCGCGCGGTGCTGAAGACGAGCGGCTGGTCGGCGGTCGACTCGCTGTCCTCGCCCGGCGGCGGCCTCTACTACGGCCGGACCAACGGCGGCCTGTACTGGTACCACGACGCCGACCCGACCGACGCGGACGGCAGCGACATCGCGTACCACCCGAACGACCCCGTCGACGCCTCCGGCTGGACGCAGACCCTGCTGTCGGCCTACGCGGACAACTGCGCCTACGTGCCGGCGGCCCCGCCGAAGTCCGTGCAGGGCGGCACGATCCACCGCAGCGAGGTCATCACCCGCGCCAAGGACTGGTACAGCCGCAACATCCAGTACAGCCAGAGTGCCTACGCCACCGACATCGAGGGCGACGACTCCTACCGCACCGACTGCTCCGGCTTCGTGTCCATGGCCTGGCACCTCACCACGTCGCTGACGACGCAGACCCTCGCCGGCGCGAGCACTCAGATCTCCAAGGCCAATCTGAGGCCGGGTGACGCGCTGAACTCCAGCAGTGAGGGCCACGCGGTCCTCTTCGCGGGCTGGAAGGACCAGGATGCGGGCACCTTCTACTACTACTCCCAGAGCAGCCCGGAGTCGGACATGAACTACAGGACCGCGAACGTGTACAGCGGCACCATCGACAGCCACGCCGCCTCGTCCTACGTCGCCCTGCGCTACGACAAGATCGCCTGACGGACGGCGACCGGCGCGGCGACAGGGCGGTTCCCCCCTCGACCGAGGGGAGGACCGCCCTGTCGCCGTTCCCGTACCGCCGGTCTAGTACCAGTTGTTCGCCTGCCAGAAGTTCCACGCGTTGCACGGGGAGCCGTAGCGGCCGTCGATGTAGCTCAGACCCCATCGGATCTGGGTCAGCGGGTTCTCGTGCCAGTCGTCGCCCGCGACGTCCATCTTCGAGGCGGGCAGCGCCTGCGGGATGCCGTACGCGCCGGAGGACGGGTTCGTGGCGTTCCAGCGCCAGCCGCTCTCGTGGTCCCACAGCTTCTCCAGGCAGGCCCACTGCGTGGAGTTGGCCCAGGCCGCGTCCTTGTCGTTCATCAGCTGCCGGCCGGCCGCCTTGACCTCGCCGATGTCGTTGCGGTCGACGCTGTCCACGGACGTGGTGCAGCTGTACGTGCGGGGCTGCGCGGACAGCAGCTTCTGCGTCCAGCCGCTGGTGTTGACCGGGTCGTCGAGGTGGTACGTGATGTCCGCGCCGGAGCCGTCGGCCGGGTTGGCGTCCTTGTACCAGTACATGGCTCCGGTGGAGAGCCTTCCGTAGTACAGACCGCCGCCCGGCGAGACGAGCTGGTTGAAGCCCGACCAGCCGGACGACTTCAGGGTGTTGCTCTTCCAGGAACCGGCACCGGCGACGGTGTAGTCGAGCAGCCGCCCGTCCGAGGTGGTGGCGCCGAGCCGGTCGTCGCCGGTCGCGGTGAGGGTCTTCAGGACGAAGCCGGTGTCGATCTCGGTGCGTACGCCGATGTGCTGGGAGCCGGCGGGCTTGTCCTCGGTGACGTTGTACCGCAGCAGCAGGCCGGCGGCGGTCGTGCCGTAGAGGTGGCCGTAACCGTCGTAGGTGAGCTTGTCGTGGGTCCAGCCGCTGTCGGCGATCCGCACCGGCGGGTTCAGCAGGGCGAGGCTGGTGTTGTTGGTCCTGATGTCGACGCGGTAGAGGGCGCCGGTGGTGGAAGTCACCAGGACGGTGTTGAAGTTGAGGGTCGCCATCGCCTGCGGCTCGAAGCCGAGGTCGGGTCCGACGAGCACCTTGGCGAGGTCGCCGGTGGCCGGGTTGATCTGGCTGAACGTGAGCCTGCCGTCGGCGAGCACACCGTAGATGTTGACGCCGCCCGAGCAGGTGGTGGCCGCGTCGGCGGTGGGGGCGGTCACCGTGAGGAGCCCGGTGCCGAGGGCGGCGGCGGTCAGCAGGACCGCGGATCTGCGGCCGCTGGTACGTCTGTTCTTCACTTCTGTTCCCCCCGGGGTGATTGAGGTGGGTGCCCGTGCGGACGAGCAGGGCAGGCGTGGTGCACGAGCCGGCGGTGGGACCGCGGCAGCGGCCGTCGGGGCGGCGGGCGGCTATTGCCAGCCGGCGTCGTCGGCCGGGTCGGCGAGAGCCGGGGCACCGACGAGAGAGGCGACCGCGGTGGCCCTGGAGACACGGGTGCGAGGCATGGCTGTCCGTTCCTTCCGGGAAGAGGTGACGGGTCCGGCCCGCTGTCGCGTCCCGCGGTGACGCGCGTCCTGGCCGGTGATCCCAGGTTCGTCGCCGCCCGGGCCCGTGAGAAGGACTCCCCGGTGGACGGAAAGGGCCTTGGACGAATGCGTCCACGCGGGCCGCCTCAGTCCACCGGGTGCGCCTCGAACGCCAGAGGCACCAGCGGAACCTCCGCACCCGTCAGTCGCGCCGCCGCCAACTGCGGGACCGCGCCCACCAGTCGGCCGCAGACGCGGACGGCCCGTTCCTCGGCCTCCTCCAACCCGTCGGCCAGCAGATAGAAGCCCAGAGTGAGCCGGGAGGCGGAGCGGGGATGCACGGCGACGTGCTCGACACGGTCCCCGTCGACGATGGCCGAGCGCACCAACCCCCGCACGCCTGGCGGCAGATGAGCGCCCGCAGGGAGTTCCAGATGCGCGTGGACGAGGTACATGCGCTTCAGCGTCTCAACGGAAGAGGCCGACGGGCGCACTCGCCGGATGGCCGATTGCGGCCGTGGCCCGTTCCGTCCTCACCCTGTGCCGAAGCGCTGCCGTTCTGCGAAGATCGCGACTCGACAGGGGACGTTGTGTGCAGAAAACGGGGGGCTCACGTGCTGACTGCACTCGGACTCGACTCCGTCGCGGAGACGGTGTACCGCACCATGCTCAGACACCCGGCCGCCGGCGTCGCGGACCTCGGCCACGCCGCGGGGCTGCCCGAGGAGGAGATACGCGAGGCCCTCGACACCCTGAGCGAGCTGGCGCTGGTGCGCCCCGCCGCCGGGGACGCGGGACGGCTGCGGGCGGTCTCGCCGGACATCGGCATGGAGATCCTGGTGGCCCGGCAGCAGGCCCGGCTGGCGGCGCAGCGGCAGCGCCTGGAGGCCTCGCGGGCGGCCGCGGCCCAGCTCATCTCCGAGTACACCGAACTGCAGCCGGCCGGCAGCCATCCCGGTGTGGAGCACCTGGTGGGCCTCGACCGGATCCGCGACCGGCTGGCCGCGCTCACCCGCGAGGTGCGTGAGGAGTTACTGACGTTCGCGCCGGGCGGGCCGCAGACCTCGGAGAACATGGCCGCCTCCCGGCCGCTCAACCAGGACCTGCTCGGCCGTGGCGTGCGGATGCGCACGATCTACCTGGACAGCGTGCGCACCAACCGGCCCACCGTCGAACACGCCAACTGGCTGGCCCGGCTCGGCGGCCAGGTCCGCACGGTGGCCTCGCTTCCCACGCGGATGATCCTCATGGACCGGCGGATCGCCATGATCTCCGTCAGCAGCGACGACACCGCCGCCGGCGCGGTCCTGCTGACCGGACAGGGCATGCTCACCGCCCTGTGCGCGCTCTTCGAAACCACGTGGGAGTCCGCGCAGCCCCTCGGCCGGGTCGTCCCCACCGACGCGCACGGCCTCACCGGCCAGCAGGCCACCACCCTGCGCCTCCTCGCCGAGGGCCACACCGACGAGGCCATCGCCAAACGCCTCGGCGTGTCCCACCGCACCGCCCGCCGCATCGCCTCCGAACTCATGGACCGCCTCGGCGCCCGCAGCCGCTTCGAAGCAGGCGTACGCGCCGTCCAGCAGGGCTGGCTGCCGCCTCATCCCTGACGTGCGCCACGCCCCGCGGCCGGTGCCCAGGACCGTCGAGGCACTGCGTCCTGGGGGTGGAGGTGCGCCGAAGGCGACACACCTGACACGGCCCCGCTCGGCCGGTTCGCGTCCTGGTCCTGGAGACTGAGCGTCACGTCCCGCGGCCGGCGCCGGCAGGGCTCTCAGGCGGCGGCAGCCGCAGGGCGAGCAGGGCCACGTCGTCGGTGCCGCCGGGCGGCGTGCGGGCGAGCAGGTGGTCGCACAGCGTGTCCAGCGGTTCGTGGGCGAGCGCGAGGGTGTGGCGGCGCAAACGGGCGAGTCCGGTGTCGAGGTCGCTGCCGGGGATCTCGATCACACCGTCGGTGTGGAGCAGCAAAGTGGAACCCGGCGGCAGCGACCGCACGGCGTCCGGCCGGCTGCCACCGGTGCCCGGACCGGCGCCGAGGAGGAGTCCCTGCCCGGCTTCGAGGTACTGCGCCCGTCCGTCCTGAGCCGGCAGCAGGGGCGGCGGATGTGCGGCGCCGGTCCACCGCAGCGTCCACCGGCCGGTGTGCGGGCTGCCTTCTTCAGCGGCGGCGCCGGGCACGGTTCAGCCCGCCGTACCGCGCCGGTGGACGTCGGGGATGCCGTCGGCGTCCGCGTCGAGGTGCTCCTCGTCCCACAGCCTGCGGTAGATGCTGTTACGGCGCTTGACCAGCACCGCGGCCATGCCGGCGGCGAGCAGTGAGCCGACCAGCACGGCGGCCTTGATCCGCTCGGTGTCCGCCGGGTCGGCGAAGGCCGCCTCGCCGATGAGCAGGGCGACGGTGAAGCCGATTCCGGCCAGAACGGCGAGGGCGAAGACATCGGCCCAGGCGAGGTCGGGGTTGAGCCGGGCCCGGGTGCAGCGGGCGGCGAGGTAGGTCCCCCCGAAGATCCCCAGAACCTTCCCGATGACCAGGCCCAGTACCACGCCCAGCGGCTCGGGACGCGTGAACACCTGGCCCAGCACGGGAGCGGAGATGCTCACCCCGGTGGCGAACAGCGCGAAGAGCGGGACGGCGACACCGGCCGACACCGGACGCAGCAGGTGTTCGGCGCGCTCCCCGGGCGAGGCGTCCTCGCCCGCATCCTGGTCGCGGGCGCAGCGAAGGATCAGCCCGATCGCCACCCCGGCCACGGTGGCGTGCACCCCGCCGTTGTACGTCAGCGTCCAGACGACCACCGCCAAGGGCACGTACCACCACCATCCGCGCACCCTGAACCGTTGCAGCAGGTAGAAGACGACCAGCCCGCCGGCAGCCCCTGCGAGGGCTGCCGGGTTCAGGCGGCCGGTGAAGAACACCGCGATGACCAGGATCGCTCCGAGGTCGTCCACGACCGCAAGCGTGAGCAGGAAGGCCCGCAGCGCGGTCGGCAGGTGGGTGCTGAGCACGGCGAGGACCGCGAGTGCGAAAGCGATGTCGGTCGCCATCGGCACCGCCCAGCCGTCGGCCCGGCCGCCGCCGACCGCGGCCGTGGCCAGGTAGATCCCGGCGGGCACCACCATGCCGCACGCCGCGGCGACCACGGGCAGGACCGCGGTGGCCGGGGTGCGCAGCCGGCCGGCCACGAGTTCGCGTTTGAGCTCGATCCCGGCGACCAGGAAGAAGACGGTGAGCAGCCCGTCGGCGGTCCAGTGCTGCACCGACAGTTCCAGTCCGAGTGCCGCTACCCCGAAGTGGACGTCGCGCAGCGCCTCGTAGGTGCCGCGCCACGGGGTGTTCGCCCACACCAGCGCCACCAGGGCGGCGATCAGCAGCACCAGGCCACCGACCGTCTCCGTGCGCAGGGCCCGGGCCACCCGGACGCGTTCCGGCCAGGGCAGGAGCCCGAGGAAGACGGACGGCCCGCGCGGGGCAGCAGACATCGGGAGGACCTCCGGGCCGCCGTGCGACGGGCACGGGCACGAACCCTCTCCGGTGCCTACCGGATGGTCCGGTGCGATCCGGCCCTTGCCGGCGCATTCATCACATGCCACCCACCGTAGCCTGCACCCAGTCGCCCGGCTGATCAGGAGCAGGAAGGCCGGGAAGGCCGCGCAGGAGTGAGAGCCCCCGAGGGCAGGAGCTGTACCTGTACCGACCGGTGTGGAACCCACCGACGTGGAGGCTGTTGCACGCCGTCTGCCGGCGAAAGTCCGTGGGCGCCGACGCGAGCGCACCGCTGCCGGCCGTGGTGGTCCGCTCCTGCGGGCGCGGATCGAGCACGAGCGGTCCCGAGGGCGCCTCCTCGATCGTCCTCCAGTACGTTCACGACCGCGGAAGCCGCGCACACGGCCGCGTACCTCTGCCGATCAGGGCAGTCTCCTCACCGCGTGAGAACCCGGCTGCCATCTCCGTCTGCCCGGTGTTCCGGGAGGTAGCGTGGTGAGAGGGCCCCCTGAAGGAGGCTGATTCCATGCCGTGGTTCGTATGGCTGATCACCGCCGCGGCGCTGGCTGCCGCGGAGTTCTTCACCCTGACACTGTTCTTCGGCCTGCTGGCGGGCGCTGCCTTGGTCGCCGCCGTGGTCGCCGGTTTCGGGATCGGCATGCTCGGACAGCTCGTTGCCTTCGGGGCAGCGGCGGCGGCGGGGCTCCTCATCGTTCGTCCTGTCGCGCTGCGGCTGGCGGAGCAGCCCCTCGTGCGCGAAGGCAGCGATGCGCTGATCGGCAAGCGGGCGGAGGTCGTGCAGGAGGTCACCGCGACCCGTGGCCTGATCAAACTCTCCGGCGAAGAATGGTCCGCCCGCGCCCTCGACGAGAGCCTGGTGATCCCGGTGGGTGCGCTGGTGGATGTCATGGAGATCGACGGCGCCAAGGCCGTCGTCTACCCCCGCGAACTCCTTCCGTGAACCGCTGAACACACAGCACCGGAGGCACTGTGGACCCCGTGGTCATCACCATTTTCGTGGCGGCCCTCGTCGTCGTCTTCCTCGTGGCCTCGACCGTGCGGATCGTCCCGCAGGCCCGCCGCTACAACATCGAGCGGTTCGGCCGCTACCGCCGGACACTGCAACCCGGCCTGAACCTCGTCCTGCCCGTGGCGGACCGGATCAACACCAAGCTCGACGTGCGCGAGCAGGTCTACTCGTCCGACCCCAGGCCGGTGATCACCGAGGACAACCTCGTGGTGAACATCGACACCGTGCTCTACTACCAGATCACGGACCCGCGGGCGGCGGCCTACGAGGTCGCCGACTACCTGCAGGCGATCGACCAGCTCACCGTGACGACGCTGCGCAACGTCATCGGCAGCATGGATCTGGAGGAGACGCTCACCTCGCGCGAGGAGATCAACTCCCGGCTCCGCGCCGTCCTCGACGACGCCACCGGCAAGTGGGGCATCAGGGTCAACCGCGTCGAGATCAAGGCCATCGATCCGCCGCACACCATCAAGGAAGCGATGGAGAAGCAGATGCGGGCCGAGCGTGACAAGCGTGCGGCCATCCTGCACGCCGAGGGGGAGCGGCAAGCCAAGATCCTCACCGCGGAAGGCACCAGGCAGAAGGACATTCTGGAGGCCCAGGGCGCGCAGCAGGCCATGATCCTTCGGGCGGACGGCGAGGCCAAGGCGGTGGAACTCGTTTTCCAGGCTGTCCATCGCAACAATGCCGACCCGAAGGTCCTGGCCTACAAGTACCTGGAGACACTGCCGCACTTGGCGGACAGCGACAACAACACGTTCTGGGTGATCCCGGGGGAGCTGACCGAGGCAGTACGGACCGTCACGCGTGCGTTCGGTGACGAGTCGCCGGCAGGCCCTGCCAGGCCCGTACCGTCCGACGAGGAAGCCACCGCCGGCGTCGACGACGTGTCGGACGACCTCCGAGTCCCGCAGCTCGACGCGGGCTCGACGGTCTCCCTCGACGCCGCCACGGCTGCCGACGAGGCCGAGAAACAGGCCGCCGCCGCGGTGAGCGACGCCAAGGCGGAGGCCGAGGCCGCGAAGTCGCCACAGATGCCGCGCCGAGGGCGGACGTAGCGAGCCGACGTGAACCCGCGTGGAGAGCCGCACCTACGGATCGGCGCCCGCTCTGTCGCTCTGTTCGCCGTAGCCGCCCTGATCGGGATCACACTGGCCTGGTGGTGTGGCAGGGGGTCCGAGAACAAAAGGGCGGCCTCTTGAGTGGGCCTGCGGACGCAGGTCTCGGCGCAGTTCAGCTGGCCTCCCAGGAACGCGCCGACGTCAGCGTAGGCCCGGTCTCTGCTCCGGCCGGAGTCGTCCGACGCGGACCCGCTCCTCGGCCCGAGGGCCGGCCGGGCGGGCCTGGTCCTCACAGGGACAGCTGTCGCCCGTGGCCGGGAGGCAGCTCCCATGGCCCCACGAAGTCCAAGCCGCCCACCTGCGTGACGGCGCACCCGCCTCGACCGTGGACGACACGTCGAACGGGCACGCCATGGGCACGTCGGCGACCGCAGGCGCGGGAAGTCCTCCTGGGAAGTACCGCCGAAGCGCTGTGAGCGACCCGCTCCGTCGCGCCGTGCGGTCGATGCGCTCGCCCGGCCGGTCCTACGGGCGGATCAGCGCAGTCCGGCGAAGAGATCGTTCTCGGGCAGGGCCGCGCCGGTGGTGTCCCGGACACGTACGAAGGTCTCCATGCCCATCAGCTCGCCGAACCTCTCCTTCCCCATCTTGAGGAAGAAGATGTTCTCGCCCTGACTGGCATGCGCGGCCAACGCGTCGAACTTCTGACCGCTGAACGCGGTGGTGTCCACCCACGTGGTGATCTCATCGTCGGGTAGGCCGATCTCGGCCATCGCGGCGGCCTCGGCAGGGTCCGGCTCCGGCATGTCCGGATGAAACTCGCGCATGATCTCACCGAACCGCTGCATCCCCGAGCGGGGCATCGTGGTCCAGTACACCTTCGGTGTCAGCGCAACCATCTCCAGCGCCGCCATCGTGATGCGGTGGGCCTGGATGTGGTCGGGGTGGCCGTAGAAGCCGTTCTCGTCATAGGTGACGACCACATCAGGTCGGTAGTGCCGCATGAGTTCCGCGAGGCGCTTCGCGCCTTCCTCCACGGGGGTCCGCCAGAAGGATCCGGGGGCGTCGTTGCTCGGCCAGCCCGCCATCCCGGAGTCGGCATAGTCCAGCGTCTCCAGATCGCTGACCTTCAGGACGTCACAGCTCGCTTCGAGTTCCTGACGACGCATCGAGGCGACCGCCGCCGGATCGTGCCCGGGCTCGCCCGGCTTGACACCTCCCGGTCCGTCACCGCAACCGCCGTCGGTACACGTCACGAGAACCGTGCGGATTCCTTCCGCCGCGTACCGCGCGAGGACACCTCCGGTTCCGGTGGCCTCGTCGTCGGGGTGGGCGTGTACTGCCATGAGCGTCAAAGGCCGGTCAGTCATGAAACAGTCCTCCTGCGGATATGAGTCCTGGCCCGAGTACGCGGCGGGCGTGCCGCGATCCTGCAGCCCGGATCCTGGTGAGGGCGGACGGCCTTGCGGCCTCAGCGCTCCGCCGTGTGGCGCCGGCCCCTCGGTAGGTGCAACCGCGCCGGACACACCGGCTGTTCCCGGCGCGGCCACTCGGCCTCCCGAGCGTCGGCGTTCAACGCGACCGGGGACAGGCACGACCCGCACGTCTCGGCACCACGTCGCATTCGGCTTCCGTCCGGTGCCGGCTGTGAGATTCCGCCACGGAAGATGAACCGCGCCGACCTCGCCACCACCGTCCGGAAGGCGAAGCACAGCGATCGGCAAGCCACCTGCCGCGCCTCCGGGCACGAGACGGCACGCGGCGGCGGACAACACCAGAGACAGCAAAAAGGCCCGGGTCTGTGACCTGGGCCTTCTTCGTGGAGCGGGTGACGAGAATCGAACTCGCGCTCTCAGCTTGGGAAGCTGCGAGCATTTGGCGCCTGTCCGGGCGATGACCTGGGGGAACGCCCTGGTTGCCGTCTCCTCAGGTTCGACCGCTTTCACCGTGATTCCCCGCTGTTCCCCGCCTCATCTGGTGCGCTTGTGGTGCGGCCCGCCCGGCGCCCGGCTCTGACGGACTGACCGTGCGTGCAGACGCGTTGGCAGGCGCATCAGAGGTGGCGCTTGGACGCTCTGACCAGTCGACTGATGTCGTCGCGGGTCTTCACCCTGCGCTGGTCCAGTTCGGGCCTGCTGTCCGTCTTGGGCAGGGCTGTGACGTCCGCAAGTACGGCTTCTGCCGCCTCGCTCAAGGCGTCGTCATCGGTGAGCATCTGCACCCGGAAGAGAGCTTCTTGGGCGTTGGAACGCAGGTCGTATGCGCGGACTCGCACCACGCTGGGGTCCTCGTGTGGCGGTTGTTCGTGTTCGCAGAACCAGAGATGTACCAGGCAGCGGCGGTAGTTGATGAGTGCGCCGGCGTAGGCGGAGTAAGCATCGAGTCGCTCCTGGCGGAGCCTCTCGTGGCGGGTGAACTGATGCCCCTTGTCGGTGGTGCGCTGCTGAAACGCCAGGGTGAGCCCCGAGCCGAGCAGGGTCCCCAGAACGGCTATGGCACTGGCGATGATGGTCTCCACACCCCAAGCTGATCACGTATCGCCGACCGGGCGCAGTACCCGCTCTGCTCTCACGCCAACACGATTTTTTACTGTGTTGGTGGGGTGCTGCCGCTCGTTCGGGTGCGTTCACCTGCGTTCATGGGCGATGGTTTGTGGATGATGCTCGCGTTCAGGTCCCTCGCGAACGGTCGCGAACGCCGCTGAACGAGACGGAAACTGAAACGGCCTCGCTCGGCATCGGAGCATGCCGGCGGGCCCGGGGCTGGACAGCGCAGGCACGCAGCAACTGCCGGTTGTGGTAGCCCATGGATCCCTCTGGGGTGGGCCACGAGCAGTGACCTCGCGATCCCCCCGGGTGACTTGGCGGCTGACTGTGGCGACGATCTGCCGCGAAGAGCGTCACAGGCATTTTCCCTGTGAGTCGGGGACGCGACTGGCGGGTGGTTGGCCCCTGAGTACTGTGTGTCCAAGGGTGGGAGCGAGCCTGCTGCGCGATGCGCGGGTATTTCCCCTCTGAACCGCCCTCGGGTGGATGAGTTGAAAAGCGCCCGTGACGCGCCCTTGACCGCCTCGCTTTCCACATACGTGATGCGCTGCATCGGTGGGCCAGGAGCTTTGTAGTAACGGCCGTCCAGCTCCACAAAGCAGGAAGGCGAGCTCTGAACTCAGGAGACGCAGTAGTCAACTGCATGTCTACATTCGGAGAACTGCGGCGGGAGATGTGCCCTCTTCAGCTGATCTGGGTCTGCCTTCGGCAGAGATTCGTTTGGTGGGGCCGGAATTCCCTGAAAGGGAGAAGCTCACCCGAGGATGGGGTAAAGTATGCACCGGTTATGCCAACAGAGCGAGGGGTCAAAATGAGGGACACGTCGGACGTCACGCGAAGGCTTTGGTCGCTTTGTTCCGTTCTTCGCGACGAAGGTGTGACCTATCACGAGTATCTCAATGAGCTTACCTATCTACTCTTTTTGAAGCTGGCTGCAGAGCTAGGGATGGAGGGGAGGCTGCCCACAAACTGCCGCTGGGCAGCTCTGCGCGAAAAGAGCAGCGACGAGGTCCCCGAGTTTTACGTTGGCCTGTTGGAGCGCCTTGGAAATTCGCCGGATACTACTGTCTCGAAGATCTATGGCGAAGCGGAAACCCGTCTCACTTCAGGTGCTGCGCTGCGTCGATTGATTGAGGGCATCGATGAGATCGACTGGTATCGCGCTCGCCAGAATGGGCTAGGTGACGTGTATGAAGGGCTCATCGAAAAGAATGCACAAGAGTCGAGATACGGAACTGGTCAATACTTTACTCCGCGCGCCGTAGTTGACGCCTTGGTGCAGGCAGTAAATCCGACGAGCAGGGACACGGTTTATGATCCTGCGGCTGGAACCGCAGGTTTCCTAGTAGCGGCCGGTCTACACACAAAGAGCAACGGTGATGAACAGCCCCGTCTGCATGGCATCGAACTTGTTCACGACGTTCAGCGCATGGGACTGATGAACATGTTGCTGCATGACCTTCAAGGTGAAATCGAACTAGGCGATTCTCTCAGCCGGGATCCTAGCGCATTCAAGGTATCGGTCTGCCTGACGAATCCGCCTTTTGGGGTCAAGGGAAATCTATCCAAAACTCAAAGTCGGCATATGGATTACCCGACATCCAACAAGCAACTTGGCTTTTTTCAGCACATCTATAAGAGCCTAAGTCCGGGGGGCCGGGCCGCAGTAGTGGTCCCTGACAACGTGCTATTTGAAGCAGGGGCCGCGTCATCAATCAGAACTCATCTCCTCGATAACTATCGACTTCACACTATCTTGAGGTTGCCCACAGGCATCTTCTATGCCACTGGGATCAGGACATCGGTCCTATTCTTTTGTGCGGATGGGCCCACGACTTCTACCTGGGTTTATGACCTCAGGTCCTCGACTAGCTTCACTAAGCGTAGGCCCCTCGGTGTTTCGGATCTCCAAGACTTTCTTGAATGCTATGGGAGTGATCCTCTCGGACGCGCAGAACGCCAGGAGACTGACAGGTTCCGGTGCGTTTCTCGCGAGGAACTAAGGTCGGCAGAGGACAGGTTGGATCTTGCTGGTACGTCGCGCAACCAGAAGGTGGTCGAAAGTGCCCAGAGGACGCCGCATGACCTTGCGGTGAGCCTTCTCGACCATGTTACTGCTGCCCAACTTGCTATCAGAGAAGTAGAAGAGATGCTGCGCGATGAATCACTGGAATCGGCGGCTCAGCAAGATTCAACCGAAGTTGGTGAAGCGTGATCAGGAAGGATTTTCCGCGCACGTGGGCGGTCTGCAGTGTGTCAGAGGCTGGGGTGGCAATCTCGGGCCAGCAGAAGACTCCGGCAGCCTCTCACGCCCCCGAGCAATTTCCGTACCTCCGAGTGGCCAATGTATTCGATGATGAGTTGAACCTGAGCGACTTGGCCACGATGCATTTCTCGAGGGAGGTCCGGGACAGGCTTCGCTTGAAGGAAGGCGACGTGCTCCTGTGCGAGGGCCAGAGTAGAGAGCTTGTAGGGCGGGCTGCTCTGTATCGAGGTGAAATCGAAGAGCTTTACTTTCAGAACAGCATCATCCGTTTCCGCCCGCACAAAGAAATACTTCCAGAGTACGCACTGCTTGTCTTTCGCGCCTATCAGAAGGAAGGCGTATTCTCTCAGATCGCGAAAGCGACGACCAACATCGCTCACCTCGGTTTGAATAGATTCAAATCCCTACCCTTCCCGGTCCCACCGCGAGCCGTGCAAGAGCTCTTGGCAGATACCGCACGCGCGTTTCAAGAACGAGTGGACACAGCGCGCCATGTTCTATCCGCGTCAATTCCCGAGCTGGATTCATTGGCGCGGGAAATTCGTGATCAAGTGCTGGTTGGGGATTACGTCCCGGAGCAGCAAAAAGGCAGATCAGGCGCAGATCGGCGCTGGAGGCCGGCGGCTGAAGTTGTCGCGCAAGATGCTCCAATCGTCTATGGAATCCTCCAGCCTGGACCGGATGTTGATGACGGGACCGGAATTCCCTACGTCCAACAGCAGGACCTCCAAAATGGTGAAATTTTGGAGGGGCATCTAAGAAGTACTGCTCTGGACGTACACGAAAAATTCGCTCGGTCCGCGATCGCCTCTGGTGACGTTCTGTTGGGAATCATTCGTAATACGCGGGTTGCAGTAGTGCCTCCGGAGCTGGACGGGGGAAACATCAACAGGGGGATTGCACGACTTCGGCCGAGCGAGGATGTTGAAAGCGAGTATCTAGCGCACTGGCTTTCCAGCGATTGGGTTCAGAGCTGGCTGGCCAATCGCATGCGAGGAATCGACATGCCAGGCGTGAATCTCCGCGATGTGCGACAGTTGCCGGTTCCTGTCCCGAGCGTGGCAGAACAGCGCATTAAGGTCCAACAAATCAACCAAGTCATTGACAAGGTTGAACTAGCCAAGTCTTCCATTGTTGAGAGTCAGCGAGAACTATTGGAAGCCGAGGCACGTACGCTTGCGGAACTGGCGTATGGCGATCTCGCGCGGAAGATTTCACGGGACTTTCGACCTGCTCAAGCTGCAGCAGAGTCCCAAGACCTAATTAGGCGCATGCGTGAGAAACAGCCCTCATCGAAAGTTAACAAGAAGAAGGTCACTCCAGTAAGGAACGTACAGGCAATGGCTGCGCAGAGTGGTGAATTGAGCGCTAATCACCTGCTTCAGGTGCTCGCGTCTTCGGGTGGCCGTATTAGCCCAGAGGACCTCTATCGCAATATGAGCTTGGACGATAATGCCGTCGACGACTTCTACGCACTTCTCCGAGATATGCAGAGAGACGGAAGGATCGATATCAATCGTCCAGATGATGCACTCGTGTTCGTAACATCGGGCGGAGTGGAATGAGAATTCTCGAAGTCAAACTACCTAGCTTCAAGAATCTGCATGACTTTCATGTGACCTTCGATAAGGACGCACCTGTGGCAGTCCTTGTCGGACGCAACGGCGCAGGGAAGTCCAATCTGCTTGAAGCGCTTACGGTGATCTTCCGAGATCTCGACTTGGGCTTCCCACCAACATTTGCCTATGACCTGGCATATGAAATCAGCGGACACTCGATCCGCGTGTCTGCTGCAGAGAATGGTGGTTCTTTTCAGTTAACGTGTTCGGTGAACGGTGAGAGTGTCCCGACCAGCAAATTCGTCGGCAACGCAGGAGCCCAGTATCGGCCTCGACATGTTTTCGGTTACTACTCTGGCCCTAGTAACCGACTCGAGGAACACTTCAGCGCCCATCAAGAGCGCTTTTACCGAGATCTGCTTCGAGGCGTGGAAAAACCCTTGCGTCCTCTCTTCTACGCGAGGAACGTCTACTCAAATTTCGTTCTGCTCGCGTTTTTCCTGGACGATGACCCCACGGTCCAGGAACTCCTCAGAGGTCAACTCGGCATATATGACCTAGATTCGGTCATGTTTGTGATGCAAAAACCTTCGTGGAGCAGTCGTTCTGGTGATAAGCGTTTCTGGAACGCGCGAGGCACTGTAAGAGGTTTCCTGGACCGACTGTATTCTCTTGCCCTTGCCCCAATGAGGCTCGATAGGCGCGTCCCTGTGGGGCTGGCAAGGTTTACGCGCTCCGAGCACCTGTTTCTCTATTTGTCAGGGCTTGCTGAGACACGTGCCCTGGCAAGTGGGTATTCCAGTAATCAGGAGTTCTTCAAAGCGCTCGAAAGTACGTTCATGTCGGAACTCATTTATGATGTTCGCATCCGAGTTTCGACGGGACGAGGTTCGTCCTCCCTCACCTTTAGGCAACTGAGCGAGGGCGAACAACAGTTGCTTCTGGTGCTGGGATTGATGAGATTTACCCGTGAAGAAGAGTCGCTCTTCCTTCTTGATGAGCCGGACACTCATCTCAATCCTGCGTGGAGTGTGCAGTACCGGAAGTTCTTGCATGACTTCGGAGCACTCGACCAGGGCTCTCATGTCTTGATGGCCACACATGATCCACTGGTTGTAGCCGGCCTGCTGAAGTCGGAAGTTCGTATCTTGGAGCGTCACCCCGACGGGACGATTTCTGCAGCTCCCCCAATCGAGGATCCCAGAGGCATGGGGGTCGGCAGCTTGCTGACAAGCGATGTCTACGGTCTCAGATCACAACTCGACCTAGAGACGCTTCAGCTTCTCGACCGAAAAAGGGACCTTGCCTCACGTGACAGGCTCTCTTCAGTCGAGGCGGACGAACTTCGTGGGTTGTCTGAAAAGCTCCAGGCGCTAGGCTTGCTGATGGAAGATAGGGACCCAGAATTCCAGGAATATCTGCGGGCGAAATTCAGCGAAGAGGGGAACGCTGATACATCACTCGTCTTTTCGCGGGAAGAGATTGAGGATAATCGTGAGGCGGCTCAGGACCTCTTGAGGGAAGTCCTTAGTGAAGGTGACTTCGGATCACTTGGGGGAGAGTAGTGATTTTCGTCGATCTAGAAGAAGTTGCCTCATTGCTCTCTGCGGAGTGGAAGAACGACTGTATTTCTGTAACTCGCGAGCTCGAACAGGCAAGCACCGCCGAAGAAAGAGCTGAGCTCCTTAAATCTCATTCCGACCTCTGGCGTGAGGTAAAAGAAAGGTTGGCTGAGGCTTCTCACGGTAAATGTTGGTACTGTGAGTCCAAGAATACGAGATCGGATAATGCGGTAGACCACTTTCGTCCGAAGGGGAGAGTTGCGGAAGACGCGACTCATCCAGGATATTGGTGGCTCGCTTTTGACTACAGGAACTATCGATTTGCTTGCACCTACTGCAACAGTAGACGTAAGCATGCTGAGTCTGGGAGCGCGGGGGGAAAGCAGGACCACTTCCCATTGGCGATCGGATCTTTTCGTGCTTGTGGCCCGAGTGATCCATGGGAGTCGGAGAAGCCACTACTCCTGGACCCGTGCTCTGTCCTGGATGTTTCAATCGTCTGGTATGACGAGGAAGGGCAGCTGAAGCTGAATCCTTCTATGGTAATTCCCGATCCTCTGGGGCAGAGTCGTATCGACGCCTCACGGATAATTTTGCACTTAGATCATCCGTACACGGTCCAGGAGAGAAAGAGGGTATATTTGAAGATCATATCCCTTTGCAACAAGGCGGACCGAATTTACAAGGCGATGTCCACCGGCAATTCCGAAATGCAGGTCATGTACAAGGAACGGCTGGCCGAGTTGGCGCAATTTCTGACCCGGTCGGCGGAGTATTCGGCTGTAGCCCGATGTGCCATTCGAGGTCACAGAGAAGCTAGCCTCACTGCGCAGATTCTCTGTGACGTGCCACTCTAGCCAGTGGGCGCAACCACAGGGGCGTGCGAGTCGAAGGTCGGCGGAGCGGCTTTGGGGTGGCGCTGCTTTGGCGCGAGTGATCATGGCCCCGTAAGCTTCCGGCGCGTCGGGCAGTCTGTGGACCTGCCCGGTAAAGCACGACGTTGGGGCCATGATCTTCGAGGCTCGCGCCAAAGTGGCTCCGTAAAGCCGTGGAGCCGACCGCCCGAGCCACGACGTACCTCTTCTCTGGCGTCAGGCAGCTGATTGCTGAGTGCGCGGCACGGGCGCCGGCCGGGCTGGAGCGGGGCGGAGACAGGAGCGCAGGCCCGGCCGGGGGCCGGGCCGCGCGCCGTGAGCGGAGCGAGCCGCCTTGAACCCGTGAAGAAGGTTGTTACTCAGTAGCGGTCGTGATGCGCCACAAGGGAGCGTCGTACTGCTGCGGACGGCTGTTGATGAGCAGCTGGCGGAGGTCCTCGCGCAGGGAGCCGTTGAGGTTCAGGGCTTCGGTGATGCGGCGGAACGTCGTATGGGTGACTCCGCGGCTGTGGGCCTCGGCTTCGAACTGGTCGAGCTGAGACAGCACAACCTCAGGGTCGAGCTGTGCCGGTGGCTGGTCCTTGAGCCATGTGGCCTTGTTGCGCTCGTAGTCGATCTCCGAGTAGCCGCAGACTTCGCGGCTGTGTGCCTCGACCTCGTCCAGGGTTGCGGTCGTCAGGATGGCGCGGGCCAACTGGTTGCGGGTGAGCGCCTTGTCCAGATCGACCTCATGGATCGCCGGGCCCTCGTCGGTGAGGGGGACTGGGAGGCCGGCGTCTCGCATCTCGCAGGTGCCGCGTACGCCTCGGGCTGTCGCCGCGAGCATCCCGGTTGCCTCGGAGGGGTGCCACTCCAGGACCGAGCTGATGGGCTCGACGTTCTTCGTGGTGAGGGTGTGGATGAGCGGGCCGAGCATGCCGCGCACTTCTTCGAGGGGGAGTTCCCCGTCGAGGCCGGGGCCCGCCACCAGGAGGCGAACAGGAGCGTTCAGCTGGCAGCACGCGGCGAGGGTGACGGCATCGGCAAGCGGGCTCTTCAACGTCGGCTCATCGCCGCGGGCGAGGATGTCGCCGCCCACGTCCAGGAGGTCGATCGACTCTGGTGACAAGTGGTCCGCCAGCTCTTCGAGTTGGCGGGTGACGCCTTCGACCCCGTAGCGCGGATCGATCAGCGCGAACGTGTGCCGGAGCTCTGCTGCGAGTCGGGGGAGAGTCGAGCCCGCCGGAGCGATCGGGCGAGCTTCGGCCGGCACTTCCCAGACCGCTGGGGTGAGGGGCTGGAGACCGGTGAAGTTGTCCGGTCCTCGGGGACCGGGAACCGGGTCGATCAGGAGGCGGTCCCACGCGTACGTGAGGATCACCGCCTGGTCCTCGTCGCCGTAGAGGGCGGCGTGAATCATTGCGGCGGCGACTGCGTCGCCCCCTCCTCCTGCTGCGACGATCAACCGCGTCATGCGGATCAGCCTACGGGGTAGGGGGTTGACCACTCACCCTATAGTGGCTAGAGGCCATAGCCACTTTTGTCGAGAAGCAGGCCTCAGCTCGGTAGCGGGGTACCCGCCTACTCGCCTGGGGCTCGCCTTGGGTGAGGAGGACTGATGCCGCAGATCGAGGAGGCTCAGCCGAAGTATCTCCAGATCGCGCACTACATCCGTGATCAGATTCTTCGGGGTGACCTGCGACCAGGAGACGAAGTGCCGTCCGAACGGCAGTTGGCGGCGGACTGGAAGGTCTCCCGGCCCACGGCCGCACGGTCGTTGGAGGCGCTGAGCCATCAAGGGCTCGTCGAGAAGCGTCAGGGTTCGGGCACGTACGTGCGGAGCCTCGAAGTCAACCGGCGGGCACGTGAGTTGTACGGGCGTGCTCGGCAGACCGGGAAGATCTACACGCCTGGCGAGTACGCCGTGATCACCTCTGCCGGTTGGCTGGAGGCGCCGGATCACGTCGCTGAGGCGCTGGGCCTGGTCAAGGATCGCCGGGCGGTGCACCGGCGGCGGGTGACCAACAACCAGGACGGGCCGATCACGCTGTCCACCTCGTGGTTCGCTCCGGATGTCGGTCAGCGCGCGCCGAAGCTGCTGGAGCCGGAGCGGATCCAAGAGGGGACGCTGCTGTACGTCGAGAACATGACCGGTCGGCAGGGGAGTTACGCGGAGGATCGCATGTGTGCGCGTGCGGCGACGGAGGAGGAGGCCGAGGACCTTCAACTTGCCGCCGACTCGGCTGTGCTGATCGTGCACCACGTCGTCTTCGACCTCCAGGACCGGCCGTTGGAGTTCGCTGAGGCCACCTACCCGCCGCATCGCTGGGCGTTCGAGCAGGGCTACCCCCTCACCTGAGGGGGCCAGTTGGGGCGAATCGCTTGCGTGGGCCAAGTGGCTAATGCCACTATCCAGAAAGTGGCTAAGGCCACTTCACTGGGAGGAGGCGCGGCGTGACGAGTCAGCGGCCAGATCAGGGCACGCACTTACCTTGCCGGGGTTGCCGGGGGCGCGGTTGGAAGCGCGTCGGCTCGCGTACGACCCTGGCGCTTGCCACCGCTGCCGACCGCGCCCGCGCTACATCGAAGCGGCGCTGCCTCGACTGCGACGGCAGCGGCACAGGAAGTGAGCACCCATGGCCTACATGATCGACCGCTACCCGTCTGAGGAGTCACCGCGTCTCGGTGCGATGACCTTGCACCCTGTCGCTGAGTCTGTGCCGCGGGCTCGGCGCTGGTTCCGCAAGTTCATCGCCCCGTACAACCCAGCCTGCTCCGTCGACGACTGCGTGCTGATGATTTCGGAGCTGGTCACCAACGCCATCGCTTACGGCCGGTCGGACGAACCCTGGCTCGTACGGGTTGAGTGGTTCCGTGAGGGGACCTCGCTCCGAGTCGACGTGCACAACCCCGGCTTTCCGGCGAACGTGCGGCTGAGGCATCCCGACGCCAACGACTCCCACGGGCGTGGACTTCTCCTGGTCGATTCGCTGGCCGAGTCGTGGCACGCCGCACCGAGCCGCTTCGGCGGAACCGTCGTCTCCTTCCTGGTAGCCGATGCCTGGCCCGGAAGGTAAGAGTTCGCTCCGCTTCTACTTTGACAATCGAAGATTCGCTAGTCTGGTTGACCAGTTGACTTGGCCAATCTCGACAGGCGGCGTTCATGGCGTATGAAGTGGAGCCACCGAAGTACGTGCGCCTCGCACAGACGATCCAGCGTCGCATCGAGGACGGCACGTACCCGCCTGGCACTCGGGTACCCAGCGAGAACCAGTTGGTGCAGTCCTTCGGGATGTCCCGCCCCACCGTCGTGCGGGCGCTGGAACTGCTGAAGCGTGATGGCTGGCTGGAGTCCCGACAGGGGTTCGGCACGATCGTGCGAGGCCGCCCGGCTGTCGTTGAGCAGAAGGACCGCCGGGGGACTGAGACGCTCACGCGCGATGAGTCGCGAGCGGCGGGCCGGTTGGTCGAAGTCGGCTACGTCCCCGTTCCGGCGCGGGTCGCATCTGTCCTCGGGCTGCCCAAGCGGGCCAAGGTTCTCATGCGCCGGTTCCTGGCGGAGGAGGATGGCGAACCGGTGGAGCTGGTGTCGTCCTACTTCCCCGCCGGCCTGGTCGAAGGTACGGAACTGGAGAGCGCCGACGCGCTGGCAGGTGGCATCCGCGCACACCTGGAGACGCGCAAGAAGGTCCGCTTCGACCATGTGACGGAACGGGTTTCGGCACGTCTGCCGGAGCCCTCCGAAGCGGAGCTTCTGGATCTCCCTGAGGGGGTTCCGGTCCTCAGTGTCCTGGTCGTCGCGTGTGACGCTTCCGGGCAGGCGCTGCAAGTCTCCGACGTGCTGCTTCCCGCCGACCGGCAGGAACTGGAAGACACCTACCGTCTGAACTGAGCCCGATGGGTGGCCCGTTCGCTGCCGCTTCATCTTAACTCGCACTTGACAAGTCAACTTGGCATCCCTAGCTTCGAACTTGCTAAGTCAACTTGTCAGGTGGCGAGTTGATCGACTCAAGAGGAGAAATCTGTGCGTGTGATCCGTATTGATGCCTCGGCCGCCACGATCCTGCTCACCGAAGCGCCGGCGCCGAAGGTGCGCGACCGGCAGACCGGTGAGATCGCCAAGGACGCCGTGAGCGGTGAGGCACTGATGACGGTCGGCGTCGTCTACATCGACGAAGGTGAGTCATCGCTGATTCAGGTCACCGTCCCCGAGAGCGGTGTGACGGAGGGCCTGACCGTCGGGGCCCCGGTCTCGCTGCCGGGGCTCATCGCCCGGCCATGGGAAAGCGTCTTTAACGGGCAGCAGCGGCACGGCATCGCCTACCGGGCGACCGCCGTTGCTCCGGGCGCCTTCCCGATGGAGCAGGCGGGCTGATCGTCGTGACCGACCTGGCGACGTGGGCCGAGCTGGGCGGGTCGCTCGCTGCGATAGGCGGCGCGGCCTACGCCCGGCATGCCCATCCGGCGGCGTACTGGTCCACGGTCGGGCTGCCCGTCTCGATGGCCCGACTGCTGGCCTCGTATACCTCCACCATGGACGCGTGCGGCCTGACGGTCGAACCTCCCCGGTGGCGGGCCCTGGCTGTCAAGGCCACGACTCGCCGTGAGGTCCGGCCCGTGCCTCCTCGCCGGGGCATGATCCGGCCCACCTCGACCGGTCTGCGGCTCCGGCTGCGGCTGGCTCCGGGCCAGGAACCGGCAGACGTGGCGGCCTCGGCCGAACGGCTGCGGCACGCCTGGGGTGTTCACGCCGTGTATGTGCGAGACGTCAAGCCCGGTGTCGTGGAACTGCGGCTCGTCGGCTTCGACGTCCTGCGGAAGGTACGGATGCCGCGTCGGATCGACGTCGGTCCGCTCCGCGTGCCGGTGGCTCTGCGGGAGGACGCGACCGCCTTCGTGCGGGACTACCAAGCCGTACCTCACGAACTCGTGCTCGGGGCCACGCTGTCCGGCAAGTCGATGTTCCTGCGGAACCTGCTTGTCGGGCTGGCCGCTCAGCCGGTGGTCCTGGTCGGGATCGACTGCAAGCGAGGGGTGGAGCTGGCGCCGTTCGCTCCCCGGCTCTCGGCGCTGGCGACCGACCCGGAGCAGGCTGCCGAGCTGCTGCCCGTGCTCGTCAAGGAAATGGAGGACCGATACGACCTGATCAAAGCGCGGCAGGGCATAGCACCTGGCACCCCGGATGAGCTGATCACCTCGGACGTCTGGGGCCTGCCGGAGGACGAACGCCCGGCTCCCATCGTGCTGTTCGTCGACGAGGTGGCAGAACTCTTTCTCGTCGCCACGAGGAAGGAGGAGGAGCGGCGGGACGAGATGGTCACCCAGCTCATCCGACTCGCCCAGCTCGGCCGGGCGGCCGGCATCTACCTGGAGGTCTGCGGGCAGCGCTTCGGGGCCGAATTGGGCAAGGGAGCGACCATGCTCCGGGCACAGCTCACCGGCCGGGTCTGCCATCGGGTGAACGACGAAGCGTCCGCGAAGATGGCGCTCGGTGACATCGCCCCTGAGGCTGTTCTGGCCTCTTGCGCCATAGCGGCTGAGTTGCCCGGCCTCGCCGTCGTCGGCGACACGTCCGGCGGCTGGTCCCGCATCCGCACCCCTCACCTGTCCCTCGCCGACGCTGCGGCCACCTGCCGCGAGACGGCGCACCTCGTCCCGGATATTCCGGCGCTCGCGCCGTTCCGGCCTCATGTTCCACCCGTGCCGGTGAAGGAGTCCGGGCCCCTGGCCACTCCTCAGCCGATCACCGAGTAACCGACTCGCTCCCACGGTCGGCGCGGCCGTCCCGCGCCAAGTCCCTACCCCACCCATGCCCGGAACTGGAAGGAGTGGCCGTGCGTGCCCTGCCCGTCCGTGTGGACGCCGTGCTCGTGCAAGCGGTGATCGCCGCCGCGCTGTCCTTCGCTCACCTGCATGACCTGGCGCTCGCTGCCGGACAGGACGGCTGGAAGGCGTGGGCCTATCCGGTCTCCGTCGACCTGCTGTTGGTCGCGGCCTGGCGGCGCCTGCGCTCCGGTGAGGCGAAAGCGGCCGGGTGGTGCTGGTTCCTCGTCGCGCTGACGGCGTCCCTAGGCGCCAACGTCGCCACCGCCGGGTTGCTCGACTTGGAGGACGTACCGGCCTGGCTCCGCATCCTCGTCGCCGGCTGGCCTGCGGTTGCCTTCCTCGGCGGCACGCTGCTCGCTCACGGAGCAGCGCATCCCGGCACGGACCCGGCTACGGCACCGGAACCACCTTCGACGGCACAGGCGCCGGAACCGACCGCCGCAGACAGTGAGCCGCCTACTGCTGCGCCCGAACTGCCGGCCGCCGCACTGGAGTCGGCGCCGCCGCCTGCAGCCCCGGTACCGCCCGCGCTCGTCACTCTCGCCCGGAAGGTCGCCGACGAACACCGCGCCCGGACCGGAACCGACATCGACACCCCGACCCTTCGCGCCCGGCTCGGTGTGCCCATGCCGCTCGCCGTAGCCATCACCACCCAACTCACCTGACCCGGAGGAATCTCCCCCTTGCGTCCGTCCACGCTCCGCGCGCTTAAGCGCGCCGCCGAGCTGACCCGACAGAACCGTCTGACCGAAGCCGTGCTGATCGCCGAGCCGGTGATCCTCGCCGCCGACAGCTACGAGGGCGACGAGATCTTGCGCTGGCTGGCCGACCACGTCACCGACTTCACCGGTGAGACCGACAAGGAGATGCCCTGATGTCCGCCAACCGCCGTTTCCGCCGCGTCGTCCGCATCGGCCCCGTCCAGGTCGGCACCTACTACGACAGCCGGGGCCGCGAGAAGCACACCGCCGCCTGCACGGCTCCGCGCTGCGGCTTCGCCACCGACTACGACAGCCGCGCCGCCGCCGAGCTGGCCGCGCGCACCCACCGCTGCCGCGTCCGCTGAGGAGTTCCCGTGACCGTCTCGCTGCCGCTCGTCTTCGTCCTGGGCGTCATCGCCTGGGCCGCGATCAAGTTCCTCGGCATCCGCCTCTGGGTCGCCGTCGTGATCGCGCTGTTCGGCTTCTGGCTCTCGCACACCATTCTCGCCCCGGCCATCGAGTCCGGTACCCGCACCGGGGTCGACGTCGTCAACGGCACCCACGAATGACACCCCGACCGACAAGGAGTCCCGCGATGTTTCGCCCCAAGCTGCCCGACACCCCGCACGTCCCGAGCATCACCACCCACATCCCGCAGGATCACGTCCCGGCTCCCTCCGCCGGCCGCTCGGTCGCCCCGTTCGTCGGGGTCGGCGCCGGTGCGGTCGCCGCCGTGGTTGTCGTCGGCGTCGTCCTCACCGCGCTCCTGGCGGCGGTCGCCGTCTCGGCCGTGTCCGTGGCCATCGCCGCCGTGGTCCTGCGCTCTCTCGTCACCGGCGCCAACAGGCGCTGACCGGCCGCCGGGGCGGCAAACGCCGCCAAGCATCCCGCCGCCCCGGGGCCGTCCCTCCCAACCGCCGAAACAGCCGAAAGGAAGACCCATCATCACCCGGCAGACTCCGCCCCCGCTGGCGGAACTCTCCATGCTGGCCTCCCTCGGCACCATGCCCGAGCTGGCCCGCCAACTCTCAGGCCTGGGCGGGTGCACGAACCCCGTGCGCCTCAACGGCCACCGCACCGAGTACGCGGTCGACCGGACGACCGGAGAGATCGGGCGCGTCCTGAACCACCTCGACTCGTCCTCCCTGCCCGCCGGAAGCCTCCTCGTCCGCTGCAACAACCGTCGCGCCACCCGCTGCGCGGCCTGCGCGGAGGTCTACCGCCGAGACACCTTCCACCTGATCACCGCCGGACTCCGCGGCGGCAAGGGCACCGCCGAACAGGTCGGCACACACCCGCGTGTCTTCGCCACCTTCACCGCGCCGAGCTTCGGCCCCGTTCACAACCGCCCTTCCAGTGGGCGGCCTTGCCGCTGCGGTGCCCGGCACGACGAGACAGACCCGGCCCTCGGTACGCCCCTCGACCCGGACGCGTACGACTACGAAGCGGCTGTCCTCTGGAACGCCCATGCCGGAGCCCTCTGGCGGCGCTTCTCGATCTACCTGCGTCGTGAGATCGCCAAGCACGCCGGACTCACCCAGCGTGCGTTTCGGGACCACGCGCGCGTCTCCTTCGCCAAGGTCGCCGAGTACCAGAAGCGGGGCGCCGTCCACTTCCACGCGGTCATCCGCCTGGACGGCCCGGAGGGCGGCGACACGGCCCCTCCCGCCTGGGCCTCCGCCGAGCTGCTGACCGACGCCATCCATGCCGCCGCCACCGCCACCCGCGTCTACGGACCGAATGTCGACGGCCGAGCCCACACCTTCACCTTCGGTCGCCAACTCGACGTACGCACCATCCGCTCCGCCGACTTCGACGGCGGCCAAGAGCTCACCGAACGGGCCGTCGCCGCGTACATCGCCAAGTACGCCACCAAAGGCGCCGAGACAGCGACCGGCACCCTAGACCGGCCGATCCGCTTCCTCGCCGAACTGGCACAGACTCGGATCACCGAGCACGCCCGGCGCATGATCCGGACGGCCTGGACCCTCGGCGCACGCAAGGACCTCGAACACCTCCGCCTGCGCGCCTGGGCCCACATGCTCGGCTTCCGCGGCCACTTCTCCACCAAGTCCCGCCGCTACTCCACCACCCTCGGCGCCCTCCGCGACGCCCGCGCCGAATGGCGCCGCGCCCAAGCGCCCACGGCCGCTCCCCAGGACGGCGAAACCACGCTCGTCCTCGCTCACTGGGTCTTCGCCGGAACCGGCCTCAGCACCGGTGAGCAATGGCTGGCCGCATCCCTCGAACCCGCCCCCGGAACGGAAGGAGAGCCCACCACATGAACGACCGCTACCTGTCCGTCGACCAGGTCGCCGAGCTACTCGGCACGACTCCCCGCTTCCCCCGGCGGCTCATCGAGGAACGGCGCATTCGATACGTGAAGGTCGGCCGGCATGTGCGTATCCCGGAGAGCGCTATCGAGGAGTTCGTTCGGGCCAGGACCGTCGAGCCGATCAAGCCTCGTCGCGCCGCACTTCGGAGGGCTGCCTGATGGTGAACAAGAAAGGGAGGCGTCGCCGCTTCGGTGCGGTGCGGCAGTACAGGTCCGGACGCTGGACCGCGTCGTACCTCGGGCCCAATGGTGAGCGCATTCGTGCGGACGAGACCTTCGACACCAAGAAGGACGCAGAGATCTGGCTGTCTCAGGTTGAGGCCGACCTCAGTCGCGGGGACTGGCGCGCCCCTGATGCCGGAGCCGTCAACTTCCGCGTGTACGCCGAGAAGTGGGTCGAAGAGCGTGAGCTGTCCGTGCGCACCGACGATCTGTACAAGCATCTCCTTCGCCTGTACATAGTCCCGACCTTCGGCACGCTCGACCTGGACGAGATTACCGCTCCCCGTGTCCGCGAGTGGCGAGCGGAGCGACTCCGCACCACCGGGGCTAAGACGGCCGTAGCCAAGGCGTACCGCCTCCTCAAGGCCATCTTGGAGACGGCCGTCGACGACGACCTGATCAGCCGCAACCCGTGCCGCATCAAGGGTGCGGGCAAGGAGTCAGCTGCCGAACGTCGTATCGCCACCGTTGCCCAGGTCGACGCCCTCGCCGACGCCATCGGCATCCGCTGGCGCCTCATGGTCTACCTGGGCGCCTACGGTCCGATGCGGCCGGAGGAGCTGGCCGGCCTTCGCCGCCGAGACGTGGACCTGGACAACCTCGTCATCCGTGTCCGCGTGGCCGAGCCCGAGCGGACGAACGGCAGACGCGCTCCCGGCGAGACCAAGTCTGACGCGGGTGTACGTACGGTCGTCCTCCCGGCCTTCCTCCACAAGGAGGTGAAGCGGCACCTAGCTTGGTACGCCGAGAAGGGGCCGGATGGTCTGGTCTTCGTTGGGGAGAAGGGTGCGCCTTTCCGGCGTACCTCCTTCGGTCGGAAGTGGCGCCGCGCTCGCGCGGTCGTCGGTCTCCCGGACGGCTTCCGTTTCTACGACCTCCGCCACACCGGGCACACCCTGTCGACCCGTTCCGGTGCCACCCTCAAGGACACGATGGTCCGTGCGGGGCAGTCCTCCGAGAAGGCCGCGCTGATCTACCAGCACTCCGACGAGGAGCGGCAGCGGGAGGTGGCCGCCGGGCTCGACGACCTGGTGCGCGCCGAGCGTGCGAAGTGCCACAAGGACGACCCCGCGCACCACAGCGAGGAGGCCGCGGAGGGCTAA

Protein sequences of DBSCAN-SWA_1

>NZ_CP022310|3780242:3822263|3808172_3809666_+|WP_142232379.1|DBSCAN-SWA
MANVFDDELNLSDLATMHFSREVRDRLRLKEGDVLLCEGQSRELVGRAALYRGEIEELYFQNSIIRFRPHKEILPEYALLVFRAYQKEGVFSQIAKATTNIAHLGLNRFKSLPFPVPPRAVQELLADTARAFQERVDTARHVLSASIPELDSLAREIRDQVLVGDYVPEQQKGRSGADRRWRPAAEVVAQDAPIVYGILQPGPDVDDGTGIPYVQQQDLQNGEILEGHLRSTALDVHEKFARSAIASGDVLLGIIRNTRVAVVPPELDGGNINRGIARLRPSEDVESEYLAHWLSSDWVQSWLANRMRGIDMPGVNLRDVRQLPVPVPSVAEQRIKVQQINQVIDKVELAKSSIVESQRELLEAEARTLAELAYGDLARKISRDFRPAQAAAESQDLIRRMREKQPSSKVNKKKVTPVRNVQAMAAQSGELSANHLLQVLASSGGRISPEDLYRNMSLDDNAVDDFYALLRDMQRDGRIDINRPDDALVFVTSGGVE
>NZ_CP022310|3780242:3822263|3818776_3818968_+|WP_142232388.1|DBSCAN-SWA
MSANRRFRRVVRIGPVQVGTYYDSRGREKHTAACTAPRCGFATDYDSRAAAELAARTHRCRVR
>NZ_CP022310|3780242:3822263|3787343_3789167_+|WP_142194162.1|DBSCAN-SWA
MTTSEGRGGRSFAADPVIEAPAELPPVWAAQLVSCVVDENVGLPDAAVLTFRDPDHEFLTATGITIGTPLRVSVVTVSGQARERLFDGEVTALEVDRDRTGSFTVVRAYSKAHRLQRGRKVVAYRNMTAAAIVRKVAAGAGLTCGTVEAAPVTYKQLSQANVSDWDFLQYLAAQSGAQVRVDDKGLLQFTRPKKASGAPAPSTPATRNPMVLEYGRNLLALRAALSAAAGASQVEVRGWDVTTKRPLVARQPSVDSDTVVPGLSPAFAARFGSSAKLTVTDTPYRTQAETTAVADAAAAQVSAAFGELEAVAEGNPRLRAGKPVALGNVGRAFSGKYTATAVQHVLEPHRGYRTTVWVSADPDRSLTGLVTGADAPGRGPRMPGLAIGVVTDVREPGGAESGAVKLRFPWLDDTYTTDWVRTVQWGGKGGGGVVSPEVNDEVLVGFEQGLLDSPYVIGGLYNGVDKPSPHDVPLIDGTTGRVNRRSVVSRSGHRVELLDARAPGPSGVRLTTGDERLEVFLDDRRDRIELTVYAKGRSPLTSVTLDGQGITLDAGRGDVSVSGRNVDIQGQVGVKVGGRSVSVTGSTDVTVDGGLLGVLKARLVRIN
>NZ_CP022310|3780242:3822263|3792091_3792655_+|WP_142232368.1|tail|DBSCAN-SWA
MSRAAVPGLPSRHPIGEQLPAVYADDDFAQRFTAGLDTVLAPVFATLDNLAAYLDPRVTPADFLAWLASWVGAADDPRRPVELRREAVVRAVELHRWRGTGRGLVEGLRLALGVHAEVTGDGGAVWSSTPGADLPPPSTTGPVVRVWPGREARVDPDRVHAIVRAMCPVHTVCRVEILPGPPADEGR
>NZ_CP022310|3780242:3822263|3817910_3818567_+|WP_142232387.1|DBSCAN-SWA
MRALPVRVDAVLVQAVIAAALSFAHLHDLALAAGQDGWKAWAYPVSVDLLLVAAWRRLRSGEAKAAGWCWFLVALTASLGANVATAGLLDLEDVPAWLRILVAGWPAVAFLGGTLLAHGAAHPGTDPATAPEPPSTAQAPEPTAADSEPPTAAPELPAAALESAPPPAAPVPPALVTLARKVADEHRARTGTDIDTPTLRARLGVPMPLAVAITTQLT
>NZ_CP022310|3780242:3822263|3798325_3799321_+|WP_142232373.1|DBSCAN-SWA
MLTALGLDSVAETVYRTMLRHPAAGVADLGHAAGLPEEEIREALDTLSELALVRPAAGDAGRLRAVSPDIGMEILVARQQARLAAQRQRLEASRAAAAQLISEYTELQPAGSHPGVEHLVGLDRIRDRLAALTREVREELLTFAPGGPQTSENMAASRPLNQDLLGRGVRMRTIYLDSVRTNRPTVEHANWLARLGGQVRTVASLPTRMILMDRRIAMISVSSDDTAAGAVLLTGQGMLTALCALFETTWESAQPLGRVVPTDAHGLTGQQATTLRLLAEGHTDEAIAKRLGVSHRTARRIASELMDRLGARSRFEAGVRAVQQGWLPPHP
>NZ_CP022310|3780242:3822263|3818585_3818777_+|WP_104783024.1|DBSCAN-SWA
MRPSTLRALKRAAELTRQNRLTEAVLIAEPVILAADSYEGDEILRWLADHVTDFTGETDKEMP
>NZ_CP022310|3780242:3822263|3819586_3820888_+|WP_142232390.1|DBSCAN-SWA
MLASLGTMPELARQLSGLGGCTNPVRLNGHRTEYAVDRTTGEIGRVLNHLDSSSLPAGSLLVRCNNRRATRCAACAEVYRRDTFHLITAGLRGGKGTAEQVGTHPRVFATFTAPSFGPVHNRPSSGRPCRCGARHDETDPALGTPLDPDAYDYEAAVLWNAHAGALWRRFSIYLRREIAKHAGLTQRAFRDHARVSFAKVAEYQKRGAVHFHAVIRLDGPEGGDTAPPAWASAELLTDAIHAAATATRVYGPNVDGRAHTFTFGRQLDVRTIRSADFDGGQELTERAVAAYIAKYATKGAETATGTLDRPIRFLAELAQTRITEHARRMIRTAWTLGARKDLEHLRLRAWAHMLGFRGHFSTKSRRYSTTLGALRDARAEWRRAQAPTAAPQDGETTLVLAHWVFAGTGLSTGEQWLAASLEPAPGTEGEPTT
>NZ_CP022310|3780242:3822263|3815239_3815968_+|WP_142232384.1|DBSCAN-SWA
MAYEVEPPKYVRLAQTIQRRIEDGTYPPGTRVPSENQLVQSFGMSRPTVVRALELLKRDGWLESRQGFGTIVRGRPAVVEQKDRRGTETLTRDESRAAGRLVEVGYVPVPARVASVLGLPKRAKVLMRRFLAEEDGEPVELVSSYFPAGLVEGTELESADALAGGIRAHLETRKKVRFDHVTERVSARLPEPSEAELLDLPEGVPVLSVLVVACDASGQALQVSDVLLPADRQELEDTYRLN
>NZ_CP022310|3780242:3822263|3801721_3802156_+|WP_142232375.1|DBSCAN-SWA
MPWFVWLITAAALAAAEFFTLTLFFGLLAGAALVAAVVAGFGIGMLGQLVAFGAAAAAGLLIVRPVALRLAEQPLVREGSDALIGKRAEVVQEVTATRGLIKLSGEEWSARALDESLVIPVGALVDVMEIDGAKAVVYPRELLP
>NZ_CP022310|3780242:3822263|3802185_3803286_+|WP_142232376.1|DBSCAN-SWA
MDPVVITIFVAALVVVFLVASTVRIVPQARRYNIERFGRYRRTLQPGLNLVLPVADRINTKLDVREQVYSSDPRPVITEDNLVVNIDTVLYYQITDPRAAAYEVADYLQAIDQLTVTTLRNVIGSMDLEETLTSREEINSRLRAVLDDATGKWGIRVNRVEIKAIDPPHTIKEAMEKQMRAERDKRAAILHAEGERQAKILTAEGTRQKDILEAQGAQQAMILRADGEAKAVELVFQAVHRNNADPKVLAYKYLETLPHLADSDNNTFWVIPGELTEAVRTVTRAFGDESPAGPARPVPSDEEATAGVDDVSDDLRVPQLDAGSTVSLDAATAADEAEKQAAAAVSDAKAEAEAAKSPQMPRRGRT
>NZ_CP022310|3780242:3822263|3819198_3819456_+|WP_142232389.1|DBSCAN-SWA
MFRPKLPDTPHVPSITTHIPQDHVPAPSAGRSVAPFVGVGAGAVAAVVVVGVVLTALLAAVAVSAVSVAIAAVVLRSLVTGANRR
>NZ_CP022310|3780242:3822263|3812452_3813550_-|WP_142232381.1|DBSCAN-SWA
MTRLIVAAGGGGDAVAAAMIHAALYGDEDQAVILTYAWDRLLIDPVPGPRGPDNFTGLQPLTPAVWEVPAEARPIAPAGSTLPRLAAELRHTFALIDPRYGVEGVTRQLEELADHLSPESIDLLDVGGDILARGDEPTLKSPLADAVTLAACCQLNAPVRLLVAGPGLDGELPLEEVRGMLGPLIHTLTTKNVEPISSVLEWHPSEATGMLAATARGVRGTCEMRDAGLPVPLTDEGPAIHEVDLDKALTRNQLARAILTTATLDEVEAHSREVCGYSEIDYERNKATWLKDQPPAQLDPEVVLSQLDQFEAEAHSRGVTHTTFRRITEALNLNGSLREDLRQLLINSRPQQYDAPLWRITTATE
>NZ_CP022310|3780242:3822263|3816456_3817830_+|WP_142232386.1|DBSCAN-SWA
MTDLATWAELGGSLAAIGGAAYARHAHPAAYWSTVGLPVSMARLLASYTSTMDACGLTVEPPRWRALAVKATTRREVRPVPPRRGMIRPTSTGLRLRLRLAPGQEPADVAASAERLRHAWGVHAVYVRDVKPGVVELRLVGFDVLRKVRMPRRIDVGPLRVPVALREDATAFVRDYQAVPHELVLGATLSGKSMFLRNLLVGLAAQPVVLVGIDCKRGVELAPFAPRLSALATDPEQAAELLPVLVKEMEDRYDLIKARQGIAPGTPDELITSDVWGLPEDERPAPIVLFVDEVAELFLVATRKEEERRDEMVTQLIRLAQLGRAAGIYLEVCGQRFGAELGKGATMLRAQLTGRVCHRVNDEASAKMALGDIAPEAVLASCAIAAELPGLAVVGDTSGGWSRIRTPHLSLADAAATCRETAHLVPDIPALAPFRPHVPPVPVKESGPLATPQPITE
>NZ_CP022310|3780242:3822263|3818977_3819172_+|WP_037765200.1|DBSCAN-SWA
MTVSLPLVFVLGVIAWAAIKFLGIRLWVAVVIALFGFWLSHTILAPAIESGTRTGVDVVNGTHE
>NZ_CP022310|3780242:3822263|3803825_3804659_-|WP_142194147.1|DBSCAN-SWA
MTDRPLTLMAVHAHPDDEATGTGGVLARYAAEGIRTVLVTCTDGGCGDGPGGVKPGEPGHDPAAVASMRRQELEASCDVLKVSDLETLDYADSGMAGWPSNDAPGSFWRTPVEEGAKRLAELMRHYRPDVVVTYDENGFYGHPDHIQAHRITMAALEMVALTPKVYWTTMPRSGMQRFGEIMREFHPDMPEPDPAEAAAMAEIGLPDDEITTWVDTTAFSGQKFDALAAHASQGENIFFLKMGKERFGELMGMETFVRVRDTTGAALPENDLFAGLR
>NZ_CP022310|3780242:3822263|3782768_3782927_+|WP_164540787.1|DBSCAN-SWA
MTYALPRLREEIAYVAYHFHWPREEILDLTHDERRQWVAEIARINTRVNEGG
>NZ_CP022310|3780242:3822263|3789658_3790081_+|WP_142232366.1|DBSCAN-SWA
MSERFIGRGWAFPLRVGPTGGIAMVEREREIEEAIRLVLGTAPGERPMRPEFGCGIHDYVFAPGDGATAGRIAQQVREALERWEPRVAVDDVVVAFDAVEDGTLYIDVHYTVRSTNDRRNLVFPFYTIPSEPGAEDGGAD
>NZ_CP022310|3780242:3822263|3782274_3782772_+|WP_142232363.1|DBSCAN-SWA
MRRRTVTAGNLDEILQATAPAPAAEQPAPPRAAAAPPAREDHGLRTEFEFELPRGYVDEAGTVHRHGAMRLATARDELRPQIDLRVKENPAYLSVVLLSQVITRIGSITDVHAGIVERMYATDVAFLQDFYRRVNSEGHTRAAVTCPHCEGGFEVDLSGGRLGES
>NZ_CP022310|3780242:3822263|3783990_3786057_+|WP_142232364.1|DBSCAN-SWA
MSPPSARLRPAGPSLTVARRPAGPVRRVPALRPTTVQNPAGPSSTPAPTAPTAGSTTAAQASTTAVQRSATSAPGPATRAPLGTPLSELPTTAVPLAKDAPIPHPAPGAAAGPALPVVQRRAEGTTGTEGSHDGRAGRTAHGGTPDGPAAPPGTPRRTSARTGARARGGLGAPLPALPASADLQGPAASGPKAPRAPARRDRSADAAPVRQDRGTDAAPVRQDRGAHAVPVPPTTERRRTSAEAASRAAGGSGADAPLLGTADVQRRPAIGSSDASTSQQPGPAPHENGPATPLVTPSPATAPQGPVPAAAAGHEGARRTGTLSGGGPGSQGQRHRSPAATMGPLVVARRVTEDTSGTSGTSGTSGPSGPSSVSGARPFGPAGPDPLTVARSGAHSASTAPRTLSLLAARPLALSTRPPEGAAPPAVRATGRPVVAARWPAHPVATRTDPPHPTTTRPDAPATPRNRNDPAPPTRRPARPEPARPAAAPATPWIQRATADHPGPQDPGVRTTGPAASVQRVPVVRPAPPHPGTSGPGAAPSAAVPARPLPVTAPQAPPLADRPPVAPAPVTAGAVPVVRRRSAALGGATGREAPPVQRTGGGDRVPPGVPAKAVPARARPQSTPGFASASATASASGRSADRRGEPAPDPGPDLDDLARRLLDPVSRLLRAELRRGRDRTGRPHDGRR
>NZ_CP022310|3780242:3822263|3805342_3805807_-|WP_142232377.1|DBSCAN-SWA
METIIASAIAVLGTLLGSGLTLAFQQRTTDKGHQFTRHERLRQERLDAYSAYAGALINYRRCLVHLWFCEHEQPPHEDPSVVRVRAYDLRSNAQEALFRVQMLTDDDALSEAAEAVLADVTALPKTDSRPELDQRRVKTRDDISRLVRASKRHL
>NZ_CP022310|3780242:3822263|3792659_3793898_+|WP_142232369.1|DBSCAN-SWA
MRACPSCGASNDPTDDFCGNCGAYLGWSDSSPAPSTPPQPSTPTPADESTPAAPPEAGEAGAAPADGSPSGDPEKPATGRPDPTSAPPRATPAATRTDRPAPGSAAPGPATPPPTRPPHPTGPDPAAASGTSARPPGPPPAPSARTPAAPTPDPVLPVRPAKPVAPRPVVRPAAAVPDEGAGVPCPACGALNAPGRRFCRRCATALNPAPKAAPLPWWRTVWPLRRRVRAGSGRAVRLLVILAVLAALCVGGVWLLPAGRALVEDTRDKLSKPKPVTPVSVEASAEIPRHPATNTTDGLSNRYWGAPAAGASVTYTFRKPFRLIDLSIINGVSKSPDQYDRQARALQLDMEVTTQDGERHHKELALADKAGPQTFPTGISDVTSIRLVLRSPVDLTNGRHLALAEVEFFQRG
>NZ_CP022310|3780242:3822263|3809662_3811225_+|WP_142232380.1|DBSCAN-SWA
MRILEVKLPSFKNLHDFHVTFDKDAPVAVLVGRNGAGKSNLLEALTVIFRDLDLGFPPTFAYDLAYEISGHSIRVSAAENGGSFQLTCSVNGESVPTSKFVGNAGAQYRPRHVFGYYSGPSNRLEEHFSAHQERFYRDLLRGVEKPLRPLFYARNVYSNFVLLAFFLDDDPTVQELLRGQLGIYDLDSVMFVMQKPSWSSRSGDKRFWNARGTVRGFLDRLYSLALAPMRLDRRVPVGLARFTRSEHLFLYLSGLAETRALASGYSSNQEFFKALESTFMSELIYDVRIRVSTGRGSSSLTFRQLSEGEQQLLLVLGLMRFTREEESLFLLDEPDTHLNPAWSVQYRKFLHDFGALDQGSHVLMATHDPLVVAGLLKSEVRILERHPDGTISAAPPIEDPRGMGVGSLLTSDVYGLRSQLDLETLQLLDRKRDLASRDRLSSVEADELRGLSEKLQALGLLMEDRDPEFQEYLRAKFSEEGNADTSLVFSREEIEDNREAAQDLLREVLSEGDFGSLGGE
>NZ_CP022310|3780242:3822263|3799892_3801191_-|WP_142232374.1|DBSCAN-SWA
MSAAPRGPSVFLGLLPWPERVRVARALRTETVGGLVLLIAALVALVWANTPWRGTYEALRDVHFGVAALGLELSVQHWTADGLLTVFFLVAGIELKRELVAGRLRTPATAVLPVVAAACGMVVPAGIYLATAAVGGGRADGWAVPMATDIAFALAVLAVLSTHLPTALRAFLLTLAVVDDLGAILVIAVFFTGRLNPAALAGAAGGLVVFYLLQRFRVRGWWWYVPLAVVVWTLTYNGGVHATVAGVAIGLILRCARDQDAGEDASPGERAEHLLRPVSAGVAVPLFALFATGVSISAPVLGQVFTRPEPLGVVLGLVIGKVLGIFGGTYLAARCTRARLNPDLAWADVFALAVLAGIGFTVALLIGEAAFADPADTERIKAAVLVGSLLAAGMAAVLVKRRNSIYRRLWDEEHLDADADGIPDVHRRGTAG
>NZ_CP022310|3780242:3822263|3816100_3816451_+|WP_142232385.1|DBSCAN-SWA
MRVIRIDASAATILLTEAPAPKVRDRQTGEIAKDAVSGEALMTVGVVYIDEGESSLIQVTVPESGVTEGLTVGAPVSLPGLIARPWESVFNGQQRHGIAYRATAVAPGAFPMEQAG
>NZ_CP022310|3780242:3822263|3793936_3794554_-|WP_167530055.1|DBSCAN-SWA
MRPVPRWALLSSVCAPVLLIAGWTVAALLEGPAYDPVTQTISVLAAYGAAGFWVMTGALLALGVCHVLTAWGLRAAAFAGRVALGGGGVVAWVVALLPPPSSGGSLRHGSVAVVGFVLLAVWPVLAAHRSGAAPWGLRPVPSLAATVVMGVGAAWFLIEMQRQGAPGVAERLVTTLQSLWPFVVVVSCVRHAGPEEGGGGAGAGC
>NZ_CP022310|3780242:3822263|3781837_3782278_+|WP_142194167.1|tail|DBSCAN-SWA
MATGDALSTHIFGVQLGGYLVESIQEISGLTVEEDVVEVKQVTAEGKRIIRKQPGGRQAGEITITRGLDQSSEFTNWIKETLNNGAVNTARQNLTIEIKDTEGNTVRRIQLMQGWASKWEGPSLQAGESSAATETVTIVFEEIVVE
>NZ_CP022310|3780242:3822263|3786143_3786569_+|WP_142194164.1|tail|DBSCAN-SWA
MTDSIFATSVFFRLAIGGNDLGAFHTCSGMGAEVEMESYAEGGNNGFTWQLPGRVTWSNITLTRPVTADTAKIGRWLDETLKRVEPKDGEIVALKPDLTRIISWQVFGIVPVRWQGPSFDPAGAEPAVETLEIAHEGLRPS
>NZ_CP022310|3780242:3822263|3813694_3814435_+|WP_142232382.1|DBSCAN-SWA
MPQIEEAQPKYLQIAHYIRDQILRGDLRPGDEVPSERQLAADWKVSRPTAARSLEALSHQGLVEKRQGSGTYVRSLEVNRRARELYGRARQTGKIYTPGEYAVITSAGWLEAPDHVAEALGLVKDRRAVHRRRVTNNQDGPITLSTSWFAPDVGQRAPKLLEPERIQEGTLLYVENMTGRQGSYAEDRMCARAATEEEAEDLQLAADSAVLIVHHVVFDLQDRPLEFAEATYPPHRWAFEQGYPLT
>NZ_CP022310|3780242:3822263|3796295_3797483_-|WP_142232372.1|DBSCAN-SWA
MKNRRTSGRRSAVLLTAAALGTGLLTVTAPTADAATTCSGGVNIYGVLADGRLTFSQINPATGDLAKVLVGPDLGFEPQAMATLNFNTVLVTSTTGALYRVDIRTNNTSLALLNPPVRIADSGWTHDKLTYDGYGHLYGTTAAGLLLRYNVTEDKPAGSQHIGVRTEIDTGFVLKTLTATGDDRLGATTSDGRLLDYTVAGAGSWKSNTLKSSGWSGFNQLVSPGGGLYYGRLSTGAMYWYKDANPADGSGADITYHLDDPVNTSGWTQKLLSAQPRTYSCTTSVDSVDRNDIGEVKAAGRQLMNDKDAAWANSTQWACLEKLWDHESGWRWNATNPSSGAYGIPQALPASKMDVAGDDWHENPLTQIRWGLSYIDGRYGSPCNAWNFWQANNWY
>NZ_CP022310|3780242:3822263|3790080_3792054_+|WP_142232367.1|plate|DBSCAN-SWA
MALPSPNLDDRRFQQLVDEAKRYVQQRAPEWTDHNVSDPGVTLIETFAYLVDQLLYRLNRVPDKNYTAFLDLLGIRLFPPAAAGAEVDFWLSAPQPDTVALPAGTEVTTAGGETDETVVFATTRQLDILPSELTRLVTAYRTGEQTDRTGTLAEGRDIPCFQAAPEPGDALLFGLPTAVPGCIVAVRLDSRVEGVGVDPRQPPLVWEAWDGGGWRVCETGEDTTGGLNRPGEVVVYVPAGHTASVIGGTRAGWLRCRVTEAEPGQPFYSESPTVREAAVFTVGGTMSVEHAETVTDVPLGTSEGVAGQTFRLGRPPVLLDGEPPVVEVSSADGWQRWEVVEHFGRSGPDDRHVRVDATTGEFAFPPVLREPDGTLRQCGAVPPKGAQVRVARYRTGGGPAGNVARGAISVLRSSVPYVARVTNREAARGGVAGETVENAKLRAPQALRMQERAVTAEDYEIISRRAAPSVRRVRCLPAADGAGAVRVLVVPDAVADEGDDRLRFEQLIPSDQVLEAITASLDERRLIGTRVVVEPPVYQGVTVVARLLAAPGDTDAVREAALDALFRHLNPLHGGPDGRGWPFGRPVQYGEVFGVLQRAGGNALVEEIRLFPADPITGRRGAPTDRIDVAPGALVFSYQHQVVVTATEPGTGGEVRG
>NZ_CP022310|3780242:3822263|3814712_3815153_+|WP_142232383.1|DBSCAN-SWA
MAYMIDRYPSEESPRLGAMTLHPVAESVPRARRWFRKFIAPYNPACSVDDCVLMISELVTNAIAYGRSDEPWLVRVEWFREGTSLRVDVHNPGFPANVRLRHPDANDSHGRGLLLVDSLAESWHAAPSRFGGTVVSFLVADAWPGR
>NZ_CP022310|3780242:3822263|3797857_3798166_-|WP_142194153.1|DBSCAN-SWA
MYLVHAHLELPAGAHLPPGVRGLVRSAIVDGDRVEHVAVHPRSASRLTLGFYLLADGLEEAEERAVRVCGRLVGAVPQLAAARLTGAEVPLVPLAFEAHPVD
>NZ_CP022310|3780242:3822263|3820884_3821097_+|WP_142232391.1|DBSCAN-SWA
MNDRYLSVDQVAELLGTTPRFPRRLIEERRIRYVKVGRHVRIPESAIEEFVRARTVEPIKPRRAALRRAA
>NZ_CP022310|3780242:3822263|3794921_3796211_+|WP_142232371.1|DBSCAN-SWA
MKLSNAVRRTSAVLAVGAMSLGLVTVTGGTAQAVASCTGDVSIYGTLSDGRLTYTQIAPNTGDRLKTLIGPDLGFTPKAMATLNFNTVLVTSTTGDLYRVDVQTNNTSLGLAGVVKIWDGGWTFDKMVYDGAGHLYGTVDGQLHQYLVSQDKPAGSAHIGQHVVIDTGFVLRTLAAAGDDRIIASTSDGRLLSYKINGVNDWDRAVLKTSGWSAVDSLSSPGGGLYYGRTNGGLYWYHDADPTDADGSDIAYHPNDPVDASGWTQTLLSAYADNCAYVPAAPPKSVQGGTIHRSEVITRAKDWYSRNIQYSQSAYATDIEGDDSYRTDCSGFVSMAWHLTTSLTTQTLAGASTQISKANLRPGDALNSSSEGHAVLFAGWKDQDAGTFYYYSQSSPESDMNYRTANVYSGTIDSHAASSYVALRYDKIA
>NZ_CP022310|3780242:3822263|3780242_3781802_+|WP_142232362.1|tail|DBSCAN-SWA
MPTYLTPGVYVEEVQSGARPIEGVGTAVAAFVGFAETGPFHTPTLVTSWDQYTQLFGGFTEGTYLPLAVYGYFANGGGAAYIVRIGGSADDASAPAAGAGRRRGAKAAQPVELGGFLVAARPGVSGVSVEIADADGENPPEDRFKVVVRQGDQVAETYEVSTRKNVKGYLVGQARASKLIEVTEQQGAAQSRPANQTVTLADAPAAPAAPGSGEVARLDPSEYVGDAGARTGFGGLETIDEITMVAVPDLMSAYQRGDIDAEGVRTVQLAVISHCEQMGDRVAVLDTPPGLTAQQARTWRNDEAGYDSRYAALYYPWVRVFDPAVGRNTTVPPSGHIAGVWARSDAERGVHKAPANEVIRGAVDLEIRLSKGEQDLLNPIGVNCVRAFPGRGIRVWGARTLSSDPAWRYLNVRRLFNYLEESILLGTQWVVFEPNDDRLWSSIRRNVTAFLTEEWRRGALFGRTAEEAFYVKCDRDNNPQESIDQGRVVCEIGVSPVKPAEFVVFRLAQFSDSTSLIDE
>NZ_CP022310|3780242:3822263|3786624_3787347_+|WP_142194163.1|DBSCAN-SWA
MSPAVRSSRARAQLTLKEPPASVGAKPGGTLARLDLQFNPSTLELRKTTEWRRSPSRMAEQSALPEFVGSGPRELSLEVFLDATATHDNSVEQAVEKLMKACVPTQASLGRKKPASPWVRFEWGTARTTSFDGVLSSLSVTYTLFDVDGKPLRATCALSIEEASVDPPGQNPTSGARTARSTHTVVAGDSLALLAWREYGDATAWRVIAEANAVDDPMALAPGTELVVPGLRDAGGEEER
>NZ_CP022310|3780242:3822263|3799454_3799889_-|WP_142194151.1|DBSCAN-SWA
MPGAAAEEGSPHTGRWTLRWTGAAHPPPLLPAQDGRAQYLEAGQGLLLGAGPGTGGSRPDAVRSLPPGSTLLLHTDGVIEIPGSDLDTGLARLRRHTLALAHEPLDTLCDHLLARTPPGGTDDVALLALRLPPPESPAGAGRGT
>NZ_CP022310|3780242:3822263|3821096_3822263_+|WP_142232392.1|integrase|DBSCAN-SWA
MVNKKGRRRRFGAVRQYRSGRWTASYLGPNGERIRADETFDTKKDAEIWLSQVEADLSRGDWRAPDAGAVNFRVYAEKWVEERELSVRTDDLYKHLLRLYIVPTFGTLDLDEITAPRVREWRAERLRTTGAKTAVAKAYRLLKAILETAVDDDLISRNPCRIKGAGKESAAERRIATVAQVDALADAIGIRWRLMVYLGAYGPMRPEELAGLRRRDVDLDNLVIRVRVAEPERTNGRRAPGETKSDAGVRTVVLPAFLHKEVKRHLAWYAEKGPDGLVFVGEKGAPFRRTSFGRKWRRARAVVGLPDGFRFYDLRHTGHTLSTRSGATLKDTMVRAGQSSEKAALIYQHSDEERQREVAAGLDDLVRAERAKCHKDDPAHHSEEAAEG
>NZ_CP022310|3780242:3822263|3789341_3789659_+|WP_142232365.1|DBSCAN-SWA
MPAAARTGDPTDHGGVIATPPPGAAAAVARVLIGGRPAAVTGSQHACAMPPHAATGPANVILPNPAAAVAGAVLIGGLPAARARDRTACGATILTGAPNVLIGGL
>NZ_CP022310|3780242:3822263|3806646_3808050_+|WP_167530056.1|DBSCAN-SWA
MRDTSDVTRRLWSLCSVLRDEGVTYHEYLNELTYLLFLKLAAELGMEGRLPTNCRWAALREKSSDEVPEFYVGLLERLGNSPDTTVSKIYGEAETRLTSGAALRRLIEGIDEIDWYRARQNGLGDVYEGLIEKNAQESRYGTGQYFTPRAVVDALVQAVNPTSRDTVYDPAAGTAGFLVAAGLHTKSNGDEQPRLHGIELVHDVQRMGLMNMLLHDLQGEIELGDSLSRDPSAFKVSVCLTNPPFGVKGNLSKTQSRHMDYPTSNKQLGFFQHIYKSLSPGGRAAVVVPDNVLFEAGAASSIRTHLLDNYRLHTILRLPTGIFYATGIRTSVLFFCADGPTTSTWVYDLRSSTSFTKRRPLGVSDLQDFLECYGSDPLGRAERQETDRFRCVSREELRSAEDRLDLAGTSRNQKVVESAQRTPHDLAVSLLDHVTAAQLAIREVEEMLRDESLESAAQQDSTEVGEA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_142232362.1|3780242_3781802_+|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	1.1e-67	34.4
WP_142194167.1|3781837_3782278_+|tail	phage tail protein	NA	NA	NA	NA
WP_142232363.1|3782274_3782772_+	hypothetical protein	NA	NA	NA	NA
WP_164540787.1|3782768_3782927_+	hypothetical protein	NA	NA	NA	NA
WP_142232364.1|3783990_3786057_+	hypothetical protein	NA	NA	NA	NA
WP_142194164.1|3786143_3786569_+|tail	phage tail protein	NA	NA	NA	NA
WP_142194163.1|3786624_3787347_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_142194162.1|3787343_3789167_+	VgrG-related protein	NA	NA	NA	NA
WP_142232365.1|3789341_3789659_+	hypothetical protein	NA	NA	NA	NA
WP_142232366.1|3789658_3790081_+	GPW/gp25 family protein	A0A1D8KT65	Synechococcus_phage	5.8e-08	31.2
WP_142232367.1|3790080_3792054_+|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_142232368.1|3792091_3792655_+|tail	phage tail protein	NA	NA	NA	NA
WP_142232369.1|3792659_3793898_+	zinc-ribbon domain-containing protein	NA	NA	NA	NA
WP_167530055.1|3793936_3794554_-	DUF998 domain-containing protein	NA	NA	NA	NA
WP_142232371.1|3794921_3796211_+	hypothetical protein	NA	NA	NA	NA
WP_142232372.1|3796295_3797483_-	peptidase S1 and S6	A0A0A0RLZ4	Streptomyces_phage	2.6e-29	68.8
WP_142194153.1|3797857_3798166_-	hypothetical protein	NA	NA	NA	NA
WP_142232373.1|3798325_3799321_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_142194151.1|3799454_3799889_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_142232374.1|3799892_3801191_-	Na+/H+ antiporter NhaA	A0A2H4J5W3	uncultured_Caudovirales_phage	4.8e-53	40.3
WP_142232375.1|3801721_3802156_+	NfeD family protein	NA	NA	NA	NA
WP_142232376.1|3802185_3803286_+	SPFH/Band 7/PHB domain protein	NA	NA	NA	NA
WP_142194147.1|3803825_3804659_-	GlcNAc-PI de-N-acetylase	NA	NA	NA	NA
3805110:3805157	attL	NA	NA	NA	NA
WP_142232377.1|3805342_3805807_-	hypothetical protein	NA	NA	NA	NA
WP_167530056.1|3806646_3808050_+	N-6 DNA methylase	A0A220A2U5	Liberibacter_phage	9.2e-18	29.5
WP_142232379.1|3808172_3809666_+	hypothetical protein	NA	NA	NA	NA
WP_142232380.1|3809662_3811225_+	AAA family ATPase	NA	NA	NA	NA
WP_142232381.1|3812452_3813550_-	DUF1152 domain-containing protein	NA	NA	NA	NA
WP_142232382.1|3813694_3814435_+	UTRA domain-containing protein	NA	NA	NA	NA
WP_142232383.1|3814712_3815153_+	ATP-binding protein	A0A1V0E640	Streptomyces_phage	4.6e-08	36.3
WP_142232384.1|3815239_3815968_+	UTRA domain-containing protein	A0A291LID1	Streptomyces_phage	6.7e-20	61.3
WP_142232385.1|3816100_3816451_+	hypothetical protein	NA	NA	NA	NA
WP_142232386.1|3816456_3817830_+	conjugal transfer protein TraS	NA	NA	NA	NA
WP_142232387.1|3817910_3818567_+	DUF2637 domain-containing protein	NA	NA	NA	NA
WP_104783024.1|3818585_3818777_+	hypothetical protein	NA	NA	NA	NA
WP_142232388.1|3818776_3818968_+	Mobile element transfer	NA	NA	NA	NA
WP_037765200.1|3818977_3819172_+	hypothetical protein	NA	NA	NA	NA
WP_142232389.1|3819198_3819456_+	SpdD protein	NA	NA	NA	NA
WP_142232390.1|3819586_3820888_+	replication initiation protein	NA	NA	NA	NA
WP_142232391.1|3820884_3821097_+	excisionase family DNA-binding protein	NA	NA	NA	NA
WP_142232392.1|3821096_3822263_+|integrase	tyrosine-type recombinase/integrase	A0A097BXY4	Mycobacterium_phage	4.9e-49	34.4
3822343:3822390	attR	NA	NA	NA	NA