CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP030034	Bdellovibrio sp. NC01 chromosome, complete genome	2 crisprs	Cas9_archaeal,DEDDh,cas3,csa3,DinG	1	1	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP030034_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP030034_1

2049188-2049342

Orphan

Consensus_repeat	Method
GCTTTCGCTTCAACCTTTTTCTT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP030034_1

>merge|NZ_CP030034|1|2049188-2049342|CRISPRCasFinder
GCTTTCGCTTCAACCTTTTTCTTAAGCTCAGGTTTTTTTGAAGCCGCTGCCTTCGCAGGAGCTTTTGCTTCAACCTTTTTCTTCACGACAGTTTTTGGTGCCGCTTTTTTAGCTGGAGCTGGCTTTGCAGCCGCTTTCGCTGGAGCTTTTTTTAC

>NZ_CP030034|1|1|2049188-2049342|CRISPRCasFinder
GCTTTCGCTTCAACCTTTTTCTT	AAGCTCAGGTTTTTTTGAAGCCGCTGCCTTCGCAGGA
GCTTTTGCTTCAACCTTTTTCTT	CACGACAGTTTTTGGTGCCGCTTTTTTAGCTGGAGCTGGCTTTGCAGCC
GCTTTCGCTGGAGCTTTTTTTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP030034.1\|WP_142698248.1\|2049529_2050507_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142698249.1\|2055830_2056202_+\|response-regulator	unknown	unknown	gnl\|CDD\|381085
NZ_CP030034.1\|WP_142696387.1\|2036545_2037175_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367156
NZ_CP030034.1\|WP_142696382.1\|2030461_2030977_-\|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl\|CDD\|100051
NZ_CP030034.1\|WP_142696385.1\|2034533_2035091_-\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NZ_CP030034.1\|WP_142696391.1\|2047770_2048247_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142696384.1\|2032232_2034434_-\|cation:proton-antiporter	unknown	unknown	gnl\|CDD\|223551
NZ_CP030034.1\|WP_142696396.1\|2053309_2054293_+\|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|237999
NZ_CP030034.1\|WP_142696389.1\|2037691_2042461_+\|tail-fiber-domain-containing-protein	unknown	unknown	gnl\|CDD\|379398
NZ_CP030034.1\|WP_142696383.1\|2031020_2032163_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl\|CDD\|335469
NZ_CP030034.1\|WP_142696397.1\|2054397_2055807_+\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP030034.1\|WP_142696388.1\|2037251_2037530_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142696399.1\|2057697_2059374_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP030034.1\|WP_142696400.1\|2059471_2060209_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142696395.1\|2052494_2053151_+\|3-oxoacid-CoA-transferase-subunit-B	unknown	unknown	gnl\|CDD\|188219
NZ_CP030034.1\|WP_142696398.1\|2056204_2057692_-\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|235619
NZ_CP030034.1\|WP_142696386.1\|2035090_2036467_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NZ_CP030034.1\|WP_142696393.1\|2050610_2051786_+\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180261
NZ_CP030034.1\|WP_142696390.1\|2042528_2047367_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379398
NZ_CP030034.1\|WP_142696394.1\|2051792_2052491_+\|3-oxoacid-CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|224702

Protein	Function_ID	Function_description	E-value
NZ_CP030034.1\|WP_142698249.1\|2055830_2056202_+\|response-regulator	gnl\|CDD\|381085	cd00156, REC, phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs). Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.	1.3124e-20
NZ_CP030034.1\|WP_142696386.1\|2035090_2036467_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP030034.1\|WP_142696382.1\|2030461_2030977_-\|gamma-carbonic-anhydrase-family-protein	gnl\|CDD\|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	2.43752e-79
NZ_CP030034.1\|WP_142696385.1\|2034533_2035091_-\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	0.00967448
NZ_CP030034.1\|WP_142696399.1\|2057697_2059374_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	0.000908892
NZ_CP030034.1\|WP_142696384.1\|2032232_2034434_-\|cation:proton-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	9.80309e-69
NZ_CP030034.1\|WP_142696396.1\|2053309_2054293_+\|cyclic-nucleotide-binding-domain-containing-protein	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	7.76334e-24
NZ_CP030034.1\|WP_142696394.1\|2051792_2052491_+\|3-oxoacid-CoA-transferase-subunit-A	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	5.78397e-112
NZ_CP030034.1\|WP_142696383.1\|2031020_2032163_-\|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl\|CDD\|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	1.93971e-76
NZ_CP030034.1\|WP_142696397.1\|2054397_2055807_+\|GHKL-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.05756e-38
NZ_CP030034.1\|WP_142696387.1\|2036545_2037175_+\|hypothetical-protein	gnl\|CDD\|367156	pfam02724, CDC45, CDC45-like protein. CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus, among others.	0.000774521
NZ_CP030034.1\|WP_142696395.1\|2052494_2053151_+\|3-oxoacid-CoA-transferase-subunit-B	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	3.38446e-120
NZ_CP030034.1\|WP_142696398.1\|2056204_2057692_-\|pyruvate-kinase	gnl\|CDD\|235619	PRK05826, PRK05826, pyruvate kinase; Provisional.	0
NZ_CP030034.1\|WP_142696389.1\|2037691_2042461_+\|tail-fiber-domain-containing-protein	gnl\|CDD\|379398	pfam13884, Peptidase_S74, Chaperone of endosialidase. This is the very C-terminal, chaperone, domain of the bacteriophage protein endosialidase. It releases itself, via the serine-lysine dyad at the N-terminus, from the remainder of the end-tail-spike. Cleavage occurs after the threonine which is the final residue of the End-tail-spike family, pfam12219. The endosialidase protein forms homotrimeric molecules in bacteriophages. The catalytic dyad allows this portion of the molecule to be cleaved from the more N-terminal region such that the latter can fold and presumably bind to DNA.	3.20639e-20
NZ_CP030034.1\|WP_142696393.1\|2050610_2051786_+\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180261	PRK05790, PRK05790, putative acyltransferase; Provisional.	0
NZ_CP030034.1\|WP_142696390.1\|2042528_2047367_+\|hypothetical-protein	gnl\|CDD\|379398	pfam13884, Peptidase_S74, Chaperone of endosialidase. This is the very C-terminal, chaperone, domain of the bacteriophage protein endosialidase. It releases itself, via the serine-lysine dyad at the N-terminus, from the remainder of the end-tail-spike. Cleavage occurs after the threonine which is the final residue of the End-tail-spike family, pfam12219. The endosialidase protein forms homotrimeric molecules in bacteriophages. The catalytic dyad allows this portion of the molecule to be cleaved from the more N-terminal region such that the latter can fold and presumably bind to DNA.	1.8747e-11

>NZ_CP030034.1|WP_142696391.1|2047770_2048247_-|hypothetical-protein
MKTLIALALVSLVSVVSQAADQFPKGPDANLTPGALCTRPTSHRYPEGINYCERNVDSGTKKDVFREYDKIGYRTLQMDRQKFKIDHYIPLCMGGANSEDNLWPQHVSVYTITDPLEPVLCEKMAQGKLLQKDAIAMIKYGKAHLDQVPAIIAKAQAL
>NZ_CP030034.1|WP_142696390.1|2042528_2047367_+|hypothetical-protein
MKHCTSLVFLAILLLMQTSFASPYSLTYQGRILKSNNNPLEYNNVSFLFSIMAPNGSCIIYQEQVDGIDMTNSGGVFDVSIGSGTKSYPVAPSFALPDAFDNSSDITCKGGATYSPVLDDGRLLRVQFHDGVGWQTISPDNVIRNVPYALHSAVAQKLGTNVASDFVKKVEVNGNTTCDSGNFLTWNATTKSFGCSGVSGASGGTVTNISSANSYLSVANGSANATLTLNVGTVANTVAAGNDPRIVNAIQSGSSASGDLSGTYPGPSVIALRGVGISATTPTSGQFFKFNGTNWTPAAIAISDVTNLTTTLSGYQTTSAFNTAVGSANCAAYETPYWNSVAGKFLCQAINVSLAGDVSGTIGAASVDKIKGYDIDLSSAPTNGQVLKYNGTKWVAASDNNGGGTVTSVSASAPLSVTNGTTTPALSISQATTSTNGYLSSADWNTFNSKQAAGNYVTALTGDVTATGPGSAAATVAKLQGSTLTITTPANKDYLKYNGTAFVNSPLAASDLSGTIPAANLPAFTGDVTSSAGSTTLTLAAAGTAGTYYKVTTDSKGRVTSGATSLVAADIPALDWSKITTGKPNSLSGYGINDQLVSNAGGTPSIQTGLDASKPGTPSAGAIYFATDSKVIYQYNSGAWVSIASATGSGGTITGVTAGTGLSGGGTTGSVTLNLANTAVTAGSYTRATITVDAQGRITSAANGAAIDLTSGVTNILPIANGGTGASTALGAINALSPLTTKGDILVRDATNNIRFPVGTNGQVLSADSAQTSGLKWITPTNGTVTNVTGTLPIVVATGTSTPAISVNAATTSAQGVVQVGSGIAVSSGTISADPANFPSLVPIAKGGTAASSITANSLVAANGTGSAYQSFTCGVGQLITFNASGVAGCSTYTTAGVYVNGGNAFGSAATLGTTDSNSLSLMTGNTNRFTLDTSGNATFINGGSTSTTPMVTIQGGAAVTTNIALRLYDAGTGGSNDNYLEFASNNGSGPVATSRIHSMGLGTQSVNGASLYFETASDNAGTWNSNQLVLANSGKVGIGTSSPAAPLDVIGNTGWIRVQQSSPDTNGPAIGFAKSRGTTAAPAQTLKGDRIGALYATGYTSGGAYGTNNGALQFVAAEDFTATGNGTKIDFGVTPVGGTARLSRMTLDSTGFLGLGTSSPTSMLHVESASVVGNQSMVLLKGNQPAGDVDDNSAVSMDFTLTDSNTNAPTNPQARIAAKVGSIHGTAAGEASGQLAFYTSVGDTTNQTFNTNTLVERMRITENGDVGIGTSSPGINNDLMGRTFLTLKGRGTTAPYGSGILQLTSNAVDGVGTNLGNIEWMDLNNNQASQRVGYISMGTSTATANNRGADMAFATRPDAGTGAIERMRINAIGNVAIGTTNNNINGKSSALLVSSSNANGWAISTYIPTTANANQITFNNPNGEVGVINTSGSTTTYSTTSDRRMKTNIADLDAEKNDAIFDKLQPRKWNWKYEQGQPQGEGFIAQELYELIPAAVSKGEGSANSKPGDKDFKMWTVDYSKLTPYLVAEAKYLKKKIVDLTAKVQTLFTTTDQHSREIASLKEQNIVMRKNSEQLRHENEKIKANALHLEQQNQMMKSYLCKKDPSAPFCK
>NZ_CP030034.1|WP_142696389.1|2037691_2042461_+|tail-fiber-domain-containing-protein
MNPCTYLVGIILVLFGLVAHASPNSFTYQGRILKSDSTPLEYNNVSFQFEITTPNGQCILYREQIDHVDMTNSGGVFDVPIGGGTQSFPGNGIFVLSDAFNNTGSLNCDGGSTYNAASSDERRLRVKFHDGSGWKTISPDNVIRAVPYSSYSYSAERLGSKTANDFVLKGDVNGNVTCNSGNFLTWDATTKTFGCSGVSGASGGTVTNVTSANAYLTVTNGAATPNLTLNVGTVANTVAAGNDPRIVNAIQSGATASGDLSGTYPGPSVVAIRSIGVAATTPASGQYFKFDGTNWTPTAIAIADVTNLSSTLSGYHTSAAFNTAVGSANCAAYETPYWNSVAGKFLCQAINVSLAGDVSGSIGAASVDKIKGYDIDLSSAPTNGQVLKYNGTKWIAGNDNNGGGTVTSVSASAPLSVTNGTTTPSLTISQATTSTNGYLSSADWNTFNSKQAAGSYITALTGDVTASGPGSATSTVAKLQGSTLTLTAPANKDYLKFNGTAFVNSPLAASDLSGTIPAANLPAFTGDVTSSAGSTTLTLAAAGTAGTYYKVTTDSKGRVTSGAASLVAADIPALDWSKITTGKPNTLSGYGIIDQLITNAGGTPSIQTGLDASKPSSPSAGAIYFATDSKVIYQYNSGAWVSIASSSGSGGTITGVTAGTGLSGGGTSGSVTLNLANTAVTAGSYTRANITVDAQGRITSAANGAAIDLTSDVTGALPIANGGTGATTALSAFNLLSPLTTKGDILVRDSSNNIRLAVGTNGQVLSADSTQASGLKWITPNAGTVTNVTGTLPIVVATGSTTPAISVNAATTSAQGVVQVGSGIAVSSGTISADPANFPSAVPTSKGGTGVTSLTPNRLLASDGTGATVTPFTCGLGQLITFDASGIAGCVTATSAGMFAKGGNAFGSAAALGTTDNYNLSFITNNTARMTILNSGNVGINTTNPGANLHVVGAAAFENNTATSSGPTFSFWKNRNYAAVNNNDELGFISFYGHDGTGTYRSSYIASHADGAPASGTHTVKGRLEFYTTGAGASDSTERMRIDSAGNVGIGTTSPTESLSVYRANATATVGITSDNTSTNTARYPAISVTNFMGSPTTGNGGNPSFNLTNFRGSSGAPAAMKSGESLGAFVFNGSSDTSGNYIEGAAIWASTTQNYSSTAAGTQLQFYTTANNTITATPRMTIDQSGYVGIGSSMTTPTYPLDVSGIIRSYGTTAGGAAVNVQATNASAYSTVDLVSDNRRYQVGTGGSSTWANGSWYLWDATASLPRMVVNSSGYVGVNTQSPQYNFQVVGNAAGTTNWMNLVNNNATGATGVLFSNDGASYGVITMNSSGQTGWSGANSLNIINQYSAPIAFFNAGGEKMRLASNGYLGIGTTTPAAALDVNMNLPAAGQAPLRIRNSATSGGSRFWQIGPDGNGSGNFIVYNDLQQGAYIVYGQTAWSASSDRRLKKEITPIEDGLNKVLQLNGVTYRYNRDKETDPRKAGVIAQDVEKVLPEAITKDDKGFLSVKYTEIIPLVIEGLKQMYSQVQSQFAEQKREIASLQSQSNDKASKTEVQELRSQNAQLKQENELIKAYLCNKDPHASFCLKH
>NZ_CP030034.1|WP_142696388.1|2037251_2037530_+|hypothetical-protein
MKNIVLLFAVLFAAVSASAQTQQQAQPLRVHPNADYIRTARVQLEKDTELKILEKLEESRLREERARMQMIEGSNFSVQNPAPNQPVQTQTF
>NZ_CP030034.1|WP_142696387.1|2036545_2037175_+|hypothetical-protein
MNPRLKSSKKWTKFPKEYSDQIQAVFKENFAQYLDEAELIIEGRIYSEEITLRVGYHEEGRISQANFEVSMNYSQDEQDALSRIHNCVDAAASMMMEYFEQDGEVDFPYVWAEYPFQGKKLYLRFSTENSSLEAEADKLLGLDGEAMVSEETDDEDALTRAEQSEELSPPRDEDEDFADEDSEEEDDGDDDSEDRGPRMFGGKGKKKVH
>NZ_CP030034.1|WP_142696386.1|2035090_2036467_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MAVADTVETTANPESANQTPKTGEGRGVYISTYGCQMNVNDTERMYSLLEMQNFEPVKTPEEADLIIINSCSVREKPVHKVMSEVGTFRKMKEKNPDMRIGIGGCVGQQEKENLIKSQPLIDFVFGTDQIDNLPNLVAKTYSEGGKHVNAKFEHRAPYNIDTLVRNPGVATFVNITKGCDNFCTFCVVPYTRGREKSRPYDHILKDVRELVTRGVKEVTLLGQNVNSYGDRDVDFAELLQKVARETDIERIRFTTSHPKDFNQKLADTMAANGDKVMEYIHLPFQSGNTRILERMNRNYTREEYLEKIAMLKRTIPNVVFSTDIIVGFPGETEEEFQDTISMCQEGGFETIFAFAYSPRPFTKAAKFEDQLPEDVKFDRLNRLFEAHDKMAFEWVKKYEGQTMKILVEQVDREHGKIQGRSTSNKLVHFMGSPDLIGKTVDVRITKAFPAVFRGELIQ
>NZ_CP030034.1|WP_142696385.1|2034533_2035091_-|bifunctional-nuclease-family-protein
MKDLLDFDNLKAQIIFTNETQDEEVFHQKDLVRLFPYGLSVTGDVSRPMLLLKDEGHQYTLPVAVSPIEAGVALSQSNKTIPQSTPHRFAEMLMNSLNIEIKQAVFVEIRGAHQYLRLYISGHPQLNSLKLRADEVISFCLHMNVPVFATKNFIGRSRVMSAEVEGQIQKSQNHGPLTGKMGYLN
>NZ_CP030034.1|WP_142696384.1|2032232_2034434_-|cation:proton-antiporter
MIHLPALITDLGFILLIGALVTLLFKKLKQPLVLGYLIAGFLVSPHVPWLPTVQDKESIHTWSEIGVIFLLFGLGLEFSFKKLVKVGGSAGFTAVFEVLFMVGLGYLVGRSIGWNSADSLFMGAILSVSSTTIIVRAFQELGMKGSRLVELVFGILVVEDVVAVLLLVLLPTLVSSNGFEIGNVVAVTTRMVFLVLVWFIFGIFLLPAFLRYIRDLLDEETTLVVAIGLCLVMVIIATAAGFSPALGAFVMGSLLAETPEGHHIEKLLNPVKNLFAAVFFVSVGMLIDPKIIRDNGGLVALFTIVTILGKLVSTYLGALLSGQSRKTSLQAGLSLAQIGEFSFIIASLGMTLKLTSDFLYPLAVAASAITTFTTPYLIKSSESIYRWTDSKFPDRFKILLDSYSSSIKRQGGKSIGGLIASSYGVKIILNSIVILAIIFGMKSFVLVQLDEHLQASPHAGAFAFIICLVISAPFFWGLLQGQPSKDVDAEDLRRIQSLLPGITLGRILLAVLLLSVMIAQFVSLPIASGALAGIVVIAVFLTMLYGEKLYAFFEKRFLRNLTEKGKETHNPAEFDPALLPWNASVETFDLGMDSSLIGKSLRELSFKEKMGVTIASINRGDRQVFAPTGDFVLWPFDRIVCFGSEEELSELHRKLNEDAEKHRWVQPFGGKYQLSSFVIENEDPYVGKSIRDSRLREDRKVLVVGVERGKNRILGPSSEFVLENGDLVWVVSE
>NZ_CP030034.1|WP_142696383.1|2031020_2032163_-|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MRKLKLFLSIAVITVLLVVSSVIAYKKTLALKTDSDSGLACSSDTSTSGRGFWASTKGAVAEKTSSSSSELSGQMVWVNGGEFWMGDATPDSEDAHPVHKVHVDGFWMDQYPVTNEEYSEFVKATGYVTVAERTLDPSAYPNVPAEMLEPGSVVFDPPKSVEQSSGHIWWHWQKGASWKHPDGPQSDLRGREKFPVVQIAYEDAEAYAQWKGKRLPTEAEWEFAARGGLDRKTYSWGDDLHPQGKFMANFWQGNFPVQNLSEDGFQGPSPVGSFPANAFGLYDMTGNVWQWTSDWYRPDYYKTLSKMRVVKNPQGPEAALDPDEPAVRKRVQKGGSYLCSEEYCGGLRPGFRGKGDVMSGSPQVGFRLVQDDGALHTVSK
>NZ_CP030034.1|WP_142696382.1|2030461_2030977_-|gamma-carbonic-anhydrase-family-protein
MSVFVKARGSEPKVEADVFIADNARLIGDVQVGKGSSIWYNVTIRGDVMPIRIGKETNVQDGTVIHGTYGKYGTTLADRVTIGHLVMLHGCEVGRGTLVGMGSILMDGVKVGEHCLIGAGSLLVEGTEIPPRSLVVGRPAKVKRPLTDEEVQLLEKSADNYLLYKSWYDEK
>NZ_CP030034.1|WP_142698248.1|2049529_2050507_-|hypothetical-protein
MSLILAKLIIQPVFAAAFAVPVQEGDRLVLKGLEAQVQLVSIPGSNAVKVVGVDENSSAEGAYVISKKDNIIEVRMNEYDGKKAWMNILPKASSQLRKIEISGLPVPTEIHLRGGSVVAQKWSKDLKVSLTQGRVSSLNGSGNLQVYVQKGDVNVADHTGKVSADTYAGSMSIKNVQGDVDASLFTGPLSLEKVHGFCAITSQIGPAKILQGTGTLQFENGKGGLNIQGFQGRVDGQNQEGSVTVQMAMDSEVDIKSKAGRVQVQAPAGSGASVNLLTIEGDIFVPNELRVNKLSSEKSVRGRLRGEGQRGSIFVRSQDGAIIVK
>NZ_CP030034.1|WP_142696393.1|2050610_2051786_+|acetyl-CoA-C-acyltransferase
MENVVIVSSVRTPVASFQGAFGSVPAPKLGAAAIKEALNRAQVSPNEVDEVIMGEVLTAGVGQAPARQAALYAGLSNNTPAMTINKVCGSGLKAVMLAADNIQLGNTKIAIAGGQENMTLAPHLLENSRSGYRMGPTQMTDSMIKDGLWDPYNNFHMGNAAEICVKEHNFTREEQDAFAVDSYKKAQKAWADGAFKNEIVAVTVEGRKGAVTVDKDEEPFNTNFDKIPGLKPAFDKAGTITAANASKINDGGAAHVLMSESEAKKRGLKPLAKIVAHGTFAHEPKYFTTAPVGAIKKALSKAGLNVGDIDLWEINEAFAVVTQVAMKELEIPAAKVNVHGGAVAIGHPIGASGARILTTLVHALHTHNKRYGLATLCIGGGEAVALIIEKA
>NZ_CP030034.1|WP_142696394.1|2051792_2052491_+|3-oxoacid-CoA-transferase-subunit-A
MSSKVYKDAMSALAGVKDGMTLVVGGFGLCGIPENCISALTEIGVKNLTCVSNNAGVDDFGLGLLLQKRQIKKMISSYVGENALFEKLYMSGELEVEFCPQGTLAERIRAGGAGIPGFYTATGVGTQIAEGKEIKNFNGRDYVLERGIVGDFALVKAWKGDKFGNLIFRKTARNFNPMAATAGKITVVEVEELVEVGELDPDQIHTPGVYVQRIFQGTNYQKRIEQKTVSKG
>NZ_CP030034.1|WP_142696395.1|2052494_2053151_+|3-oxoacid-CoA-transferase-subunit-B
MPLTREQIAQRISKEVQDGYTVNLGIGIPTLVANYIPADKTVMLQSENGLLGMGPFPKESEVDPDLINAGKQTVTTVKGSSFFSSADSFAMIRGGHVDLTVLGAMEVDEQGSIANWMVPGKMVKGMGGAMDLVAGAQNVIVAMQHTDKEGNSKLRTKCTLPLTGIKCIKKIVSDFGVIEVTPQGFVLKEYAPDLTPEKVLAATEGKMTIAPDCKAMTF
>NZ_CP030034.1|WP_142696396.1|2053309_2054293_+|cyclic-nucleotide-binding-domain-containing-protein
MADAKKIAKDHYLFREGDAPDAMYIVKSGTLAVTKTKGNTEVVLAEIQAGAMVGEMALFDNKPRSANVKATKETEVIALPYDSLNKQMDTLPVWVRAIMKNLNENLREANKKIKLLENSNPNEERFPPHIVNKYLSILNLVGNKYGKAEPNDGLSISSVLLRNYTIQIFQEATNKMQTVVNALTDLGYVTQEDRGDGSQKITNLKPQELFGFVDWYNEWLFKQEKDRLPEITEAEVKILNGILLFAKRSEPDRKGLYKVNLNDVQNESMKETGSLIKVDDVNPLIEKKYLTEKIMDTAGVYILVELPYVEPLARNWTLVNNLRKKLR
>NZ_CP030034.1|WP_142696397.1|2054397_2055807_+|GHKL-domain-containing-protein
MDLEGFNTIQVLHHLYNLDQLLIGKDYIRALVQRIGEELHVKYVMVGHAIEPEQTKVESDFMWADGQFVDNVIYDLEGTPCVHVLCGTRVNCYAQGVALAFPEDKMLTNMKIESYIGAPFLHTDGGLIGLLVIMDDKPLEEYETLQTVVEFCAARIGTEYRRIAFEESLRKVKENLEQQVQDRTKEYQLAFEKLQRTQRQMISQEKLATIGRITFGIAHELKNPLNVIINSAEIIQDLIHEDMCAESIEKLALMIHEHGDRANEIITSMLKQARQESEDTTESIDVPTLIDRSLEMCLRSLSDLSFKSDLKVEKDIGSNLKTLVVNPAGIERVFINLFDNALYAMSKKYHSEKAQGYKPIIKVALEKVEKNLKITIRDNGTGIPKKFLTNLFTEFFTTKPSGEGTGLGLYIARQTLQKSDGDISINSEDGQFTEIIIFLPHQELPSPTLNPTKDIATDKKRPTTNEAMP
>NZ_CP030034.1|WP_142698249.1|2055830_2056202_+|response-regulator
MVDDERDVGLLSELNFRSAISTGKIHFHYFEDPLKCLQYLEKHDGGSDTLVLTDINMPELTGFDLLENIRDKHPNVLVFMMSAYDDNDCIEKAMRLGATGYFTKPVSYKKVKSRITEEFGIAI
>NZ_CP030034.1|WP_142696398.1|2056204_2057692_-|pyruvate-kinase
MLADRRAKIVATIGPATRDEKNLEKAIKAGMNVARLNFSHGSHEDHLKVVHSLRKLSKELRAPVAILQDLQGPKVRVGKFENGSIEIKPGEKLVVTTAKVLGKPGLIPSDFKELPLACVPGTRILLDDGLMEIKVLQVRGEELDVEVIYGGILKDRKGMNLPGVNLPVDCMTEKDLEDLEFGIANKVDYIALSFVRHARDIRKLREILEERKSNAKIIAKIEMIEAIENLEEICRLSDAVMVARGDLAVEVGQSRLPGFQKRIISVCNQLGRPVITATQMLDSMVENPRPTRAEITDVANAVLDGTDALMLSAESASGKHPFKCIRTMHEIICEVENNEEKYYKLSLENEFLSAPAAIAASASLSALKLNATAIICLTTSGKTANIISGFRPRARIISVTQHMDVLNQMELAWGIQTHVIKSYKTMEDILTQVDQLLVTHGLAKTGDRVILTLGQPIAQGAKTNSIYVHTVGGESYSKLPDEQLPLRCQMDPPIE
>NZ_CP030034.1|WP_142696399.1|2057697_2059374_-|hypothetical-protein
MSSISSSDRSRQDDRVRQTREEYENRESENTKRRSEELKRLESRHHEEIKNITDEYENRIAELKDRNRETLTNKDFENNRKIDEVRETYRNSLRNKMEEAYDQREAQKSAYESTLEKQKQINESQKQNLVGQMNDEVSSRDDRFNTAIEANRKKAQESVQSNTRKLNEAHEKEVTAMRRSSEDQMAAKNRATDEMRKSYEGRLKNSERMREADNARWSQKYSDTVKNSAEEYADNLDIKQQLLDQERGSLRDKYDNKLEAKTEALDRQNEEFRDSVNERVNGQIRSRDSKIQRLSSKLNNEMSKNERLRGIERKNLTNAYEKRMAQLNEQRDDAIDRMKELNDGRISDINDRTQKLLQNADREAKSNSTITNLRHREERETMQQQHKDQLEQVNNNAESRVRKMADLTNKNQKVLGKYYADSLDQMEANYTERMDGQREKTTADQTALNKVMTERFRGMEANFNSRLEQTVKSYEDKLAALKENQDRELKRVENMYSQRLDEREKSAKSEKQSVEMKYEARLAQLNESHQDQLDRMNRRHQEDMQNLSTKLSSYSRKA
>NZ_CP030034.1|WP_142696400.1|2059471_2060209_-|hypothetical-protein
MKKFFRVLIFIMAFQMEVRVRASGDVMQQPTACLKSKESCTIHVTGPVFHLERGDFKMHASEDSTLMRASAQQWRLMKGTVWMEEANNVEVETVYATVKATHGQYWVLDQGDKITIRNIDAELEVTLRDGKKLEVPSGFEFWVAGFNSKNQNEYGMIRPIDMKEHLPVWNALYKGSKENFVKEVKDLKENWGDMAEKSAAVYKVTTERKLAAVAEAERKEAAKKRLDEQKRQELKSLYFQRTFER

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Crispr_ID: NZ_CP030034_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP030034_2

3866128-3866201

Orphan

Consensus_repeat	Method
AAAAAAGCTACAAAAAAAGCAGCTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP030034_2

>merge|NZ_CP030034|2|3866128-3866201|CRISPRCasFinder
AAGAAAGCAGCAAAAAAAGCTACAAAAAAAGCAGCTAAAAAAACTACTAAAAAAGTAGCAAAAAAAGCGACTAA

>NZ_CP030034|2|2|3866128-3866201|CRISPRCasFinder
AAGAAAGCAGCAAAAAAAGCTACAAA	AAAAGCAGCTAAAAAAACTACT
AAAAAAGTAGCAAAAAAAGCGACTAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP030034.1\|WP_142698000.1\|3859568_3860267_+\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|319354
NZ_CP030034.1\|WP_142698016.1\|3873210_3874083_+\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP030034.1\|WP_142698003.1\|3861524_3862058_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142698002.1\|3860986_3861475_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142698001.1\|3860251_3860842_+\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|187726
NZ_CP030034.1\|WP_142698012.1\|3869364_3870096_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213228
NZ_CP030034.1\|WP_142698011.1\|3867869_3868589_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376777
NZ_CP030034.1\|WP_142698013.1\|3870180_3870936_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213228
NZ_CP030034.1\|WP_142698007.1\|3864807_3865245_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142698015.1\|3872040_3873204_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP030034.1\|WP_142698006.1\|3864569_3864779_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142698017.1\|3874180_3875092_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367555
NZ_CP030034.1\|WP_142698354.1\|3858612_3859572_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP030034.1\|WP_142698014.1\|3871083_3872028_+\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|180477
NZ_CP030034.1\|WP_142698005.1\|3863516_3864563_-\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|107204
NZ_CP030034.1\|WP_142698356.1\|3868585_3869365_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376777
NZ_CP030034.1\|WP_142698004.1\|3862342_3863506_-\|cystathionine-gamma-synthase	unknown	unknown	gnl\|CDD\|366438
NZ_CP030034.1\|WP_142698355.1\|3866421_3867024_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP030034.1\|WP_142698010.1\|3867084_3867861_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|224380
NZ_CP030034.1\|WP_142698008.1\|3865232_3865973_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP030034.1\|WP_142698000.1\|3859568_3860267_+\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|319354	cd16833, YfiH, protein of unknown function YfiH. This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.	1.3602e-62
NZ_CP030034.1\|WP_142698016.1\|3873210_3874083_+\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP030034.1\|WP_142698017.1\|3874180_3875092_-\|hypothetical-protein	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	0.00363455
NZ_CP030034.1\|WP_142698001.1\|3860251_3860842_+\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|187726	cd00540, AAG, Alkyladenine DNA glycosylase catalyzes the first step in base excision repair. Alkyladenine DNA glycosylase (AAG), also known as 3-methyladenine DNA glycosylase, catalyzes the first step in base excision repair (BER) by cleaving damaged DNA bases within double-stranded DNA to produce an abasic site. AAG bends DNA by intercalating between the base pairs, causing the damaged base to flip out of the double helix and into the enzyme active site for cleavage. Although AAG represents one of six DNA glycosylase classes, it lacks the helix-hairpin-helix active site motif associated with other BER glycosylases and is structurally distinct from them.	1.73103e-88
NZ_CP030034.1\|WP_142698012.1\|3869364_3870096_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	6.65163e-126
NZ_CP030034.1\|WP_142698011.1\|3867869_3868589_-\|ABC-transporter-permease	gnl\|CDD\|376777	pfam02405, MlaE, Permease MlaE. MlaE is a permease which in E. coli is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. In NMB1965 it is involved in L-glutamate import into the cell. In Arabidopsis thaliana TGD1 it is involved in lipid transfer within the cell.	1.33732e-63
NZ_CP030034.1\|WP_142698013.1\|3870180_3870936_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	4.75541e-120
NZ_CP030034.1\|WP_142698014.1\|3871083_3872028_+\|malate-dehydrogenase	gnl\|CDD\|180477	PRK06223, PRK06223, malate dehydrogenase; Reviewed.	3.42054e-169
NZ_CP030034.1\|WP_142698015.1\|3872040_3873204_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP030034.1\|WP_142698354.1\|3858612_3859572_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	5.56239e-100
NZ_CP030034.1\|WP_142698005.1\|3863516_3864563_-\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	2.90069e-157
NZ_CP030034.1\|WP_142698356.1\|3868585_3869365_-\|ABC-transporter-permease	gnl\|CDD\|376777	pfam02405, MlaE, Permease MlaE. MlaE is a permease which in E. coli is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. In NMB1965 it is involved in L-glutamate import into the cell. In Arabidopsis thaliana TGD1 it is involved in lipid transfer within the cell.	1.5095e-58
NZ_CP030034.1\|WP_142698004.1\|3862342_3863506_-\|cystathionine-gamma-synthase	gnl\|CDD\|366438	pfam01053, Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.	0
NZ_CP030034.1\|WP_142698010.1\|3867084_3867861_-\|MCE-family-protein	gnl\|CDD\|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	9.61726e-18

>NZ_CP030034.1|WP_142698008.1|3865232_3865973_-|hypothetical-protein
MIILFSISMLGQALIHRTLLRISQEFAISQHTFRSLMILNAVLVSFLAISFHSSPISLWLFIGIILITLKFFPGILRFFMMRTLSSALIPLLDSVILGLQSGKSFRFALHAAIENQNGWRRNQLREIYNFIITSDAVHSAKSALLKDLQAELAEIDRSNARTIDQVKALRRNLKLRENFRRRSGQVTQQIKMQAIIVTALFSALLSFVIVQFGFFQHRFLILASFFIFMIGLFWIFNVGRKMKWKV
>NZ_CP030034.1|WP_142698007.1|3864807_3865245_-|hypothetical-protein
MEGVAPPLELLLAVKRSLEKGQTAKQGILNYLKRCEGEFPTTVSKWMALLHQGKETQTLISGISSQHRQVLLQLLERGMRGEAIYNVLLTLEEEIMEACHEELTNKLARLPFILLVPLLLFQFPAFLMLLFGPLLQNFFHSLGGG
>NZ_CP030034.1|WP_142698006.1|3864569_3864779_-|hypothetical-protein
MSKELVTRKNLEKLVDELMKDQPNRQTVKKLTSELGMAYSVDPLTQMNTVLQSMNSVYLPSNRRDDLER
>NZ_CP030034.1|WP_142698005.1|3863516_3864563_-|pyridoxal-phosphate-dependent-enzyme
MSHILDSILETVGDTPMVALHNVTKGSKHKFFAKIEYFNPGGSIKDRVAVAIIEEAEKRGDLKPGGTIVEATSGNTGVGLALAAAVKGYKCIIIMPEKMSEEKRALLRAYGAQVVITPMVEPDHPMSHYNVSKRIAAQIPGAFLANQFFNPDNVTKHYQTTGPEIWKQTDGKIDMLVGGAGTGGTLSGCAKYLKEQKKDVKIICADPVGSILYDLYYHKKIVDPPGSYKVEGIGEDMLPGNVHLDIYDGFIRVNDQEAFDMTRRLVSEEGLLVGPSSATALVGAIKASEKVEKPMNIVVVFPDSGRQYLSKAFNDRWMVDNGLLKEEQIKDAFNRVISAEDALKIYNK
>NZ_CP030034.1|WP_142698004.1|3862342_3863506_-|cystathionine-gamma-synthase
MKKTTQDLGFATRAIHAGQSPDPTTGAIMTPVYMTSTYVQESPGVHKGWEYSRTHNPTRRAYENCMASLENGKFGFAFASGCAATTTILHLLKGGDHVVAMDDMYGGTFRLFDKVLKHDGMEFSFVDLTKFENFEKAIKPNTKMVWLETPTNPTLKLVDIKKIAAHAKAKGILVAVDNTFMSPYFQKPLDLGADIVVHSATKYIGGHSDVVGGIAVTSREDLAERIQFLTNSMGGIQAAFDAFLCLRSLKTLPLRMKAHQENAMAIAKFLESHPKVEKVIYPGLESHPQHALAKAQMSGFGGMITFYIKGGMESARKFLENVNVFSLAESLGGVESLIEHPAIMTHASVPPENRKALGIDDSLIRLSVGVEDLQDLLNDLKSAFDKA
>NZ_CP030034.1|WP_142698003.1|3861524_3862058_-|hypothetical-protein
MKLAISFLSFLVPSFVFAAQSQGVTPDFTCMAELPTTSFYSKPIKNEDGDELVEFKVQHHFGVDNAPVFQGVVTGHDFPYLQQRLEVIKKLGNTFTVKFKKVNCLKSGDELFSCGSGSDSEINGVPVTGFGFTTRVIDTKVYEYKFKSNQVTFSFTYEGMSYDIPMQYGPDECNFKN
>NZ_CP030034.1|WP_142698002.1|3860986_3861475_+|hypothetical-protein
MKALFLSLLTLIACSSAFATVNANSSWEEINATPYLNPKAPTVYMGRSIDYMMVCRNGDRLQTTKPVDITETRTYGDRQEIVVVGREILSTPIHYSLVQENCFSQGGQNSRTVCKKQRITGSYPMTVQVPVYQLLTPKRTYQQYRFTKSYTIPNCAGEPTPQ
>NZ_CP030034.1|WP_142698001.1|3860251_3860842_+|DNA-3-methyladenine-glycosylase
MSDLLILPQEFYMEDTTQIAKDLLGKVLHIKIQNEEFRARIVETEAYLGIDDPAAHSYGDKNTPRIQSMYQEGGHSYVYMIYGMYFCLNFVTREKGNPQAVLIRGVEPLPSQHGVKKKDLKTNGPGKLCKYYGINRSHDGIKLWKKRSELYVSDDGFEVLKKQIVAKPRVGVDYAGEAASWPLRFYLKDNLYVSKK
>NZ_CP030034.1|WP_142698000.1|3859568_3860267_+|peptidoglycan-editing-factor-PgeF
MNIEQTPLGYEIRTPHLIMLFGGVNAQIPALKAAYPDIDFVRVKQIHSDAVVESENSSTDLQVIADAHITKNKNVGICVITADCVPLLFYHQGTGTIAGVHAGWRGVANRITIKTIEKLIASGIPAEELDVIIGPHIQKKSFEVGLDVRDQILGSLGTLTEAQRTLFTEKISEDKALVDLNQVVKAQLQSMNIQADRVFDLHIDTFTNPDFHSHRRDKEKAGRQVSFICRIS
>NZ_CP030034.1|WP_142698354.1|3858612_3859572_+|RluA-family-pseudouridine-synthase
MAGLRLDKALALIPEIETRSRAAHLIDNSAVMVNGKIEKASAKIKEGDSIEITLPDPTPTELQPYDLKLDVLFEDEDVIVINKPAGLVVHPAAGHAHDTLVNALISHTDDLSMKFGEERPGIVHRLDKETSGIIVVAKNDKAHESLTAQFKERSTHRIYFAVSIGTARTMSGTFRSFLARHPVDRKRYASIIGDDGYPLSDQEDPPLSGKWAVTHYEVLNRKAGLSYLKLKLETGRTHQIRVHLSENSLPIAGDLLYGADRKIKSIEQKSIQEDLKNLPRFLLHAAELGFTHPRTGERLSFKKDWPEDILVLLKKWGLV
>NZ_CP030034.1|WP_142698355.1|3866421_3867024_-|hypothetical-protein
MGVSAAQAAALSANSETISSKALSIEKAYSQDMKTESNTMSYSSTLKMREELRMGAGISVGGQLGSVGINAEFNFEDENSVMAGFGTGPGYNSISLAWKHAFEGDYIAPYFTAGYSRWYNSRGHSDAWKDSDILDRVLTSDEKATGRFGTNFVNGSFGIQYNQLSGTFYGFSAYAEIVAMYEITRSQLIPSGTVGTLYYF
>NZ_CP030034.1|WP_142698010.1|3867084_3867861_-|MCE-family-protein
MKVETKVGLLALVSFALIALFAYFMGLVSPFSNTKELNVMYNYAGGIEEGSPVRVMGIKVGKVKSITFDPAFKMANGEEAKLRLTITIDKKAWTSVRKDSKFFINLAGVIGEKFLEISAGSMDAGEFSNGDYVRGEDPPRIDQLISQGYGLAGKLIEIVEKNQGSVTNVIKQLDNLTTNFNKTLMLLDKTTKNREMARLLDNAVKISDDLAYLTGNLRSKKAEETYDLVHKLLFRLEPVDGPALKKFFQTEGVRARVF
>NZ_CP030034.1|WP_142698011.1|3867869_3868589_-|ABC-transporter-permease
MISLFAETFFGIFVSPFRRKEFLQQLHFVANRSLIIIVFCVCFAAIVTILESSFHMKMVIQNDSMVPGFAAVLILRELAAVVMALLLASRVGAGYASEVGSMQITEQVDALKMLGIDPVNYLVVPRFLACILGAMMLTVVANMTCLLSAMMISQSYLSYTPGMFLSSMHRFVQFRDIIFAMIKGACFGAVIPIVACYFGFNCQQGAEGVGKATTNTVVVASIGIIVIDFILSYTFSHMY
>NZ_CP030034.1|WP_142698356.1|3868585_3869365_-|ABC-transporter-permease
MGLFIHLLDEVGGNLLFFKELLISLLKKTPKSRDVFDQIWKVTTDSFFTTAMAGFFVGAIMSVQFAMLMKEFGALGYLGGLSTSATFREVGPLLIAFMLSGKVGAYTSAELGTMRVTEQIDAVRCLGADPIQEIIAPRFVGIIIASFFLLGGGLIMSVLGGMLMGNLFAGVNFEEYLRHIPTIVNPISILSGLVKCGTFAVVLATVCTFKGYYTSGGAKGVGRSVVSTAVTTMVAIVVMDWFTSFIGEIILQMIRGYRS
>NZ_CP030034.1|WP_142698012.1|3869364_3870096_-|ATP-binding-cassette-domain-containing-protein
MIEFKNLVKRFGTRTVLNGLNLEIREGEIIFVLGTSGTGKSVLLKNIVGLLKPDEGEIWIDGEEVSQFTEDQYFPIRKKCGMVFQHPALFDSLTIYENVAFGLRRHFQLSEDEIKARVGKALNLVHIQGVEEKRPAQISYGMQKRVSLARTIALQPKILLFDEPTTGLDPVTTTAVNQLIQDLSKKLRTTSIVVSHDMNCALSIADRIVVLDKGQIVALGTPDELKRSTHPLVKDFLEEVLHA
>NZ_CP030034.1|WP_142698013.1|3870180_3870936_-|ATP-binding-cassette-domain-containing-protein
MSIIRLQDVTVAFDSQIVLSSINLEIKAGESFVIVGPSGQGKTVLLKTLAGLITPQNGKVFVEQQEWLTLSPKARLPLLKKMGILFQKNALFDSLTCLENICFPLRETTELSETEILNKAEYFLDAVGIPHARDLFPDEISGGMQKRLGIARALALNPEIIFYDDPTAGLDPITSKKIIELIIDLKKKNNSTVVAITNDMNRAYQLADRIGMVVNQELLITGTPEQTKNHPDPRVHQFIRGMVEGPLTAQA
>NZ_CP030034.1|WP_142698014.1|3871083_3872028_+|malate-dehydrogenase
MAHTRKKIAVIGAGFVGSTTAHWAAQKELGDVVVLDVNEGAAIGKMLDLAQASAIEMFDTRVKGTSKYEDIADSDVVIITAGMPRKPGMSRDELVGINAKIVKDVCEGVKKYAPNSYVIVVCNPMDVMAVYAKQILGFPRERVIGMGGCLDSARFRTFIAEELNVSVKDVNGIVLGNHGDAMVPMVRHASVSGIPLTELLPADKIAAIVARTKQAGAEIGGHLKTGSAYYAPARGAVEMAEAILKDQKRVLPVAVELTGEFGVNEGLMVGVLATIGGKGVEKIHKFEMNPAEQEEFKKSVDAVRTLVSALKTVQ
>NZ_CP030034.1|WP_142698015.1|3872040_3873204_+|ADP-forming-succinate--CoA-ligase-subunit-beta
MNIHEYQAKEVLRKFGVATLKGKLAHSPEEAVAAAKEIGGSVWVVKAQIHAGGRGKGGGVKVAKSLDEVADYTKKMIGMTLVTHQTGPEGKVVQKVFIEQGCNIAKEYYVACLIDRATGRAAMMASSEGGMDIEEVAEHNPNAIKKVDIDPTVGLMPFQARELAFQIGMDPALVGKATKFFQGLYNAFIATDCSIAEINPLVVTKENDVFALDAKMNFDSNSLFRHPDIVEMRDLNEEEPSEIEASKFDLAFIKLDGNIGCLVNGAGLAMATLDIIKLHGAEPANFLDVGGGANKEKVTEAFKIILKDKNVKGILVNIFGGIMKCDIIAEGVIAASKELGLKVPLVVRLEGTNVELGKKMLRESGLNITPADNLTDAAKKIVAAVKG
>NZ_CP030034.1|WP_142698016.1|3873210_3874083_+|succinate--CoA-ligase-subunit-alpha
MAILINKNTKVICQGFTGAQGTFHSEQALAYGTKMVGGVTPGKGGTTHIGLPVFNTVKEAKAATGCNASVIFVPPPFAADSIMEAVDADLDLVICITEGIPVLDMVKVKKYMQGKRTRLIGPNCPGVITPGECKIGIMPGSIHKPGRIGVLSRSGTLTYEAVGQLTALGLGQSTAVGIGGDPVNGTNFIDVLKLFNEDPDTDGVIMIGEIGGSAEEEAAEYIKNHFKKPVTAFIAGAAAPAGKRMGHAGAIISGGKGTAEAKFAALEAAGCKISRSPADMGVTMQSMLKK
>NZ_CP030034.1|WP_142698017.1|3874180_3875092_-|hypothetical-protein
MKTPQWLGLSIAIHGLALGAVFLFEFKNSTPQQVVEFEIQSAPVAASFKQNKNHGTGKSSAQTAVANNNSGKGKKVSLKGTDLFGQQYSFNQADTGSGSGDAAAPTTDFTDRQNYIFDAGSMLADTDQWEFYRQVFERIDSQLVFDSILAQYNHFGNVFVEFEVDAQGRFVDHRLKISSDDSVLKVHSMRALRKGLKEPFRKEKWNPSGKNAILQAHFEFLHGDTAINFKKQKEFGKAIFVFKRATIEGPITNDIVDTVVSKETIINPYLIGERLEKYNKKKRLKAGEYDPFASYRNDPDYNL

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP030034_2	2.1\|3866154\|22\|NZ_CP030034\|CRISPRCasFinder	3866154-3866175	22	NZ_CP030034.1	3902450-3902471	1	0.955

1. spacer 2.1|3866154|22|NZ_CP030034|CRISPRCasFinder matches to position: 3902450-3902471, mismatch: 1, identity: 0.955

aaaagcagctaaaaaaactact	CRISPR spacer
aaaagcagctaaaaaaacttct	Protospacer
******************* **

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP030034_2	2.1\|3866154\|22\|NZ_CP030034\|CRISPRCasFinder	3866154-3866175	22	MN693872	Marine virus AFVG_250M911, complete genome	52680-52701	2	0.909
NZ_CP030034_2	2.1\|3866154\|22\|NZ_CP030034\|CRISPRCasFinder	3866154-3866175	22	MN693786	Marine virus AFVG_250M1027, complete genome	14472-14493	2	0.909

1. spacer 2.1|3866154|22|NZ_CP030034|CRISPRCasFinder matches to MN693872 (Marine virus AFVG_250M911, complete genome) position: , mismatch: 2, identity: 0.909

aaaagcagctaaaaaaactact	CRISPR spacer
taaaacagctaaaaaaactact	Protospacer
 ***.*****************

2. spacer 2.1|3866154|22|NZ_CP030034|CRISPRCasFinder matches to MN693786 (Marine virus AFVG_250M1027, complete genome) position: , mismatch: 2, identity: 0.909

aaaagcagctaaaaaaactact	CRISPR spacer
taaaacagctaaaaaaactact	Protospacer
 ***.*****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1175982 : 1215952

Tetraselmis_virus(14.29%)

protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_142695593.1\|1175982_1177188_+\|protease	carboxy-terminal processing protease	NA	NA	NA	NA
WP_142695594.1\|1177361_1177976_+	hypothetical protein	NA	NA	NA	NA
WP_142695595.1\|1178015_1179221_+	RDD family protein	NA	NA	NA	NA
WP_142695596.1\|1179220_1180165_+\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_142695597.1\|1180273_1181161_+	nuclease	A0A2P0VMP9	Tetraselmis_virus	4.6e-15	34.8
WP_142695598.1\|1181330_1181885_-	hypothetical protein	NA	NA	NA	NA
WP_142695599.1\|1182234_1182666_-	hypothetical protein	NA	NA	NA	NA
WP_142695600.1\|1182792_1183236_-	hypothetical protein	NA	NA	NA	NA
WP_142695601.1\|1183675_1186624_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_142695602.1\|1186721_1187309_-	fumarylacetoacetate hydrolase family protein	NA	NA	NA	NA
WP_142695603.1\|1187305_1187797_-	histidine phosphatase family protein	NA	NA	NA	NA
WP_142695604.1\|1187870_1188782_+	Hsp33 family molecular chaperone HslO	NA	NA	NA	NA
WP_142695605.1\|1188910_1190128_+	sensor histidine kinase	NA	NA	NA	NA
WP_142695606.1\|1190200_1191112_-	hypothetical protein	NA	NA	NA	NA
WP_142695607.1\|1191113_1191578_-	hypothetical protein	NA	NA	NA	NA
WP_142695608.1\|1191664_1192663_-	isocitrate/isopropylmalate dehydrogenase family protein	NA	NA	NA	NA
WP_142695609.1\|1193118_1193727_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_142698192.1\|1193928_1194114_+	hypothetical protein	NA	NA	NA	NA
WP_142698193.1\|1194246_1194528_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_142695610.1\|1194603_1195896_-	hypothetical protein	NA	NA	NA	NA
WP_142695611.1\|1195927_1196233_-	hypothetical protein	NA	NA	NA	NA
WP_142695612.1\|1196444_1196729_-	hypothetical protein	NA	NA	NA	NA
WP_142695613.1\|1196976_1197855_+	peptidase	NA	NA	NA	NA
WP_142695614.1\|1197872_1199036_+	MFS transporter	NA	NA	NA	NA
WP_142695615.1\|1199321_1200071_-	hypothetical protein	NA	NA	NA	NA
WP_168196394.1\|1200257_1201643_-	PAS domain-containing protein	A0A1V0SGX0	Hokovirus	2.6e-49	36.3
WP_142695617.1\|1201681_1203127_-	lipase maturation factor family protein	NA	NA	NA	NA
WP_142695618.1\|1203155_1205486_-	endonuclease MutS2	A0A076FGT9	Aureococcus_anophage	1.0e-05	27.6
WP_142695619.1\|1205463_1207107_-	apolipoprotein N-acyltransferase	NA	NA	NA	NA
WP_142695620.1\|1207107_1207902_+	hypothetical protein	NA	NA	NA	NA
WP_142695621.1\|1207908_1209285_-	S8 family serine peptidase	A0A2K9L1P3	Tupanvirus	5.7e-20	38.5
WP_142695622.1\|1209465_1209969_+	hypothetical protein	NA	NA	NA	NA
WP_142695623.1\|1210082_1212251_-	DUF3808 domain-containing protein	A0A0S2SXL7	Bacillus_phage	2.1e-08	28.5
WP_142695624.1\|1212294_1213194_-\|protease	protease HtpX	NA	NA	NA	NA
WP_142695625.1\|1213268_1215614_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	1.0e-154	40.2
WP_142695626.1\|1215610_1215952_-\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	3.3e-14	50.0

DBSCAN-SWA_2

1838538 : 1846721

Escherichia_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_142696165.1\|1838538_1839525_-	dTDP-glucose 4,6-dehydratase	A0A291LAD7	Escherichia_phage	6.4e-66	41.7
WP_142696166.1\|1839521_1840409_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	7.2e-85	54.3
WP_142696167.1\|1840412_1841549_-	dTDP-4-amino-4,6-dideoxygalactose transaminase	A0A2K9L470	Tupanvirus	5.9e-23	32.1
WP_142696168.1\|1841588_1843235_-	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.7e-10	33.7
WP_142698235.1\|1843551_1844322_+	hypothetical protein	NA	NA	NA	NA
WP_142696169.1\|1844459_1845194_+	HlyD family efflux transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_142696170.1\|1845195_1845966_+	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.9e-17	31.9
WP_142696171.1\|1845962_1846721_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	4.1e-20	24.4

DBSCAN-SWA_3

3158019 : 3165465

Bacillus_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_142697376.1\|3158019_3159519_-\|tRNA	proline--tRNA ligase	A0A2K9L0T2	Tupanvirus	6.1e-84	37.2
WP_142697377.1\|3159531_3160914_-	sigma 54-interacting transcriptional regulator	W8CYM9	Bacillus_phage	7.4e-12	33.3
WP_142697378.1\|3160944_3163146_-	PAS domain-containing protein	W8CYF6	Bacillus_phage	1.8e-12	25.9
WP_142697379.1\|3163163_3163733_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.2e-16	39.6
WP_142697380.1\|3163732_3164863_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	1.1e-56	39.0
WP_142697381.1\|3164865_3165465_-	riboflavin synthase	A0A1V0SE20	Indivirus	5.7e-25	36.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP030034

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection