CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP037858	Stenotrophomonas maltophilia strain X28 chromosome, complete genome	8 crisprs	DEDDh,csa3,Cas9_archaeal,DinG,WYL,cas3	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP037858_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_1

142403-142516

Orphan

Consensus_repeat	Method
CGATCAACCACGCATGGCGTGGATCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP037858_1

>merge|NZ_CP037858|1|142403-142516|CRISPRCasFinder
CGATCAACCACGCATGGCGTGGATCTACTGGCCGTGCCGACTTTGGTGGGTGCCGACCGTTGGTCGGCACGGAAGCCCGTGCCTCTCGATCATCCACGCATGGCGTGGATCTAC

>NZ_CP037858|1|1|142403-142516|CRISPRCasFinder
CGATCAACCACGCATGGCGTGGATCTAC	TGGCCGTGCCGACTTTGGTGGGTGCCGACCGTTGGTCGGCACGGAAGCCCGTGCCTCT
CGATCATCCACGCATGGCGTGGATCTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_111112597.1\|147538_148009_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_010485892.1\|130672_131080_-\|flagellar-basal-body-rod-protein-FlgC	unknown	unknown	gnl\|CDD\|183634
NZ_CP037858.1\|WP_010485865.1\|145325_145940_-\|high-frequency-lysogenization-protein-HflD	unknown	unknown	gnl\|CDD\|234690
NZ_CP037858.1\|WP_099552268.1\|132822_133479_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	unknown	unknown	gnl\|CDD\|183625
NZ_CP037858.1\|WP_099552257.1\|149505_151791_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	unknown	unknown	gnl\|CDD\|236828
NZ_CP037858.1\|WP_142805931.1\|143156_143504_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_032127372.1\|135600_137373_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP037858.1\|WP_005409577.1\|131617_132562_-\|chemotaxis-protein-CheV	unknown	unknown	gnl\|CDD\|381151
NZ_CP037858.1\|WP_142805928.1\|134286_135507_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340419
NZ_CP037858.1\|WP_006366325.1\|133856_134195_+\|flagellar-protein-FlgN	unknown	unknown	unknown
NZ_CP037858.1\|WP_142805927.1\|133554_133860_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	unknown	unknown	gnl\|CDD\|274802
NZ_CP037858.1\|WP_142805929.1\|137377_139480_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|226951
NZ_CP037858.1\|WP_005409592.1\|148121_148448_+\|ATP-dependent-Clp-protease-adapter-ClpS	unknown	unknown	gnl\|CDD\|178809
NZ_CP037858.1\|WP_099552261.1\|145936_147079_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP037858.1\|WP_099552265.1\|139611_142371_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NZ_CP037858.1\|WP_049446361.1\|143601_143817_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_142805933.1\|147075_147537_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239647
NZ_CP037858.1\|WP_099552270.1\|131083_131479_-\|flagellar-basal-body-rod-protein-FlgB	unknown	unknown	gnl\|CDD\|183628
NZ_CP037858.1\|WP_142805934.1\|148554_149367_-\|APH(6)-family-putative-aminoglycoside-O-phosphotransferase	unknown	unknown	gnl\|CDD\|226100
NZ_CP037858.1\|WP_142805932.1\|143915_145070_-\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|206779

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_142805932.1\|143915_145070_-\|chemotaxis-protein	gnl\|CDD\|206779	cd11386, MCP_signal, Methyl-accepting chemotaxis protein (MCP), signaling domain. Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.	6.59018e-31
NZ_CP037858.1\|WP_010485865.1\|145325_145940_-\|high-frequency-lysogenization-protein-HflD	gnl\|CDD\|234690	PRK00218, PRK00218, lysogenization regulator HflD.	1.23642e-86
NZ_CP037858.1\|WP_099552268.1\|132822_133479_+\|flagellar-basal-body-P-ring-formation-protein-FlgA	gnl\|CDD\|183625	PRK12617, flgA, flagellar basal body P-ring formation protein FlgA.	5.68664e-106
NZ_CP037858.1\|WP_099552257.1\|149505_151791_+\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA	gnl\|CDD\|236828	PRK11034, clpA, ATP-dependent Clp protease ATP-binding subunit; Provisional.	0
NZ_CP037858.1\|WP_032127372.1\|135600_137373_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	4.29048e-97
NZ_CP037858.1\|WP_005409577.1\|131617_132562_-\|chemotaxis-protein-CheV	gnl\|CDD\|381151	cd19924, REC_CheV-like, phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins. This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.16931e-37
NZ_CP037858.1\|WP_142805928.1\|134286_135507_+\|sensor-histidine-kinase	gnl\|CDD\|340419	cd16943, HATPase_AtoS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.	1.99288e-52
NZ_CP037858.1\|WP_010485892.1\|130672_131080_-\|flagellar-basal-body-rod-protein-FlgC	gnl\|CDD\|183634	PRK12629, flgC, flagellar basal body rod protein FlgC; Provisional.	6.04545e-81
NZ_CP037858.1\|WP_142805927.1\|133554_133860_+\|flagellar-biosynthesis-anti-sigma-factor-FlgM	gnl\|CDD\|274802	TIGR03824, FlgM_jcvi, flagellar biosynthesis anti-sigma factor FlgM. FlgM interacts with and inhibits the alternative sigma factor sigma(28) FliA. The C-terminus of FlgM contains the sigma(28)-binding domain.	1.36752e-13
NZ_CP037858.1\|WP_142805929.1\|137377_139480_-\|PAS-domain-S-box-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.66031e-42
NZ_CP037858.1\|WP_005409592.1\|148121_148448_+\|ATP-dependent-Clp-protease-adapter-ClpS	gnl\|CDD\|178809	PRK00033, clpS, ATP-dependent Clp protease adaptor protein ClpS; Reviewed.	4.26539e-44
NZ_CP037858.1\|WP_099552261.1\|145936_147079_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP037858.1\|WP_099552265.1\|139611_142371_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	5.47924e-106
NZ_CP037858.1\|WP_142805933.1\|147075_147537_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239647	cd03675, Nudix_Hydrolase_2, Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.74868e-71
NZ_CP037858.1\|WP_099552270.1\|131083_131479_-\|flagellar-basal-body-rod-protein-FlgB	gnl\|CDD\|183628	PRK12620, flgB, flagellar basal body rod protein FlgB; Provisional.	1.55413e-77
NZ_CP037858.1\|WP_142805934.1\|148554_149367_-\|APH(6)-family-putative-aminoglycoside-O-phosphotransferase	gnl\|CDD\|226100	COG3570, StrB, Streptomycin 6-kinase [Defense mechanisms].	1.66636e-75

>NZ_CP037858.1|WP_099552265.1|139611_142371_+|EAL-domain-containing-protein
MDQGIIASLLQHPLASALVIVDRTGRPLAANPAAREHGLPATVAAYAPMLEDLRLMAADGGIVACTLPGGPHGHYDGHLRAVHDGAGNLLAFTLSIPEPVPLGGGGRWELALDSAGHSLWDWDIPSDRVVRTPALGDETATEILARVHSEDIAQVRFALDEHLRGLSEQYSAQFRFRQADGQWRWVLDRGRVVARTADGQPLRMVGTHTDIEQQKQLEGLLQEQQLHLSEAQRIASMGSWSFDPNSGHFWWSPELRSLLALEQGAVPGQRRWLKQLHPRSRGALRAAWRRLWRDGRAANLELELTRGPEPSQHLRLWMQPLLDMDGQPKRLLGQVQNITEQHQTDALIRWRTELLNRVSALGRIGGCEIEVQTRHMQWTEECYRIHGLRKEPITLDQALALYTEDSRNAFEAALGRIADGGLPEQLDLCFYRQSGLRVWVQVLIELDRRDGLPPRFVVLFRDITREREANERIELLAHYDLLTGLPNRVLLGEQTAEAIEEARDRGTSLAMLFIDLDGFKTINDSFGHATGDALLKAAATRLHQNLRNNDLFGRFSGDEFIVVLRDLAEPEDAGHVARKLIASLAEPLRRGETTLKVGASVGIAMLGDAQTDFDSLLRAADAAMYAAKEAGRNTYQYYSQDALARIQRKLELEHALHGAIEREEFSLAYQPLLHAHHGEPPAIEALLRWHRPGIGYCSPAEFIPIAEKCGEIVRIGDWVLNEACRQATAWDRAGLRFDRIAVNVSAVQLRDRGFAERVIEICHAHGWPPQRLELELTESALIRDTDILRHCFDVLERHGVPLAVDDFGTGFSNLNYLNRFPVGRLKIDRSFVQGMLHDSGTAEVTQAIVHLGHALGMKVVAEGVETHQEEDMLRRQGCDEIQGYLYSRPLSPRDLAQWLRQPQPAPMRTDASGEAVLVR
>NZ_CP037858.1|WP_142805929.1|137377_139480_-|PAS-domain-S-box-protein
MPAEPTGTAPVPDPRMAQALSRDRRRVVLSYLVMALAWMIASDSAVQALVPDPQQAAMWQSVKGSFFALASAGLLYLLLRPLAEHVLHTHARQQASELRLRQMFEGNPGPILVYDLDTLAILDANPAACSAFGWERDELLEQTIDSLWPPGQDQALQTKLEAIREAPEELCVLRTQLQLRDGSLRQMELRSNAISYDGHNARLLIAIDRTAEDLAQLRRDQALARVEEAHELARIGAWELDPSTGMGRYSNQVYRLLGRRPPEARRWHRFDELLVPADPATATQTEQLLAELCSGDPVQVDVLLPLLSMDGRALMVHLRAASGVDESGRSRVLGTLQDVTEREQSRRLLREREEQFRELVRVLPDGVVILSDEHVLYTNAWAASLFGYGSHTLLGEPLSALVAAGDLARVRGQLRAGQPHLGPGHSSVVAMQRADGRSFHAGLAVGEVRYGGRDCKLLIVRDLSDSERTRSALETSNRELQAMAGRLFSLQEDERRAISRDLHDDIGQAITAIKLSAHAAQDEHDPQRRGEDLAQIVSLADTTVAKLRDISTLLRPPQLDALGLEAALSWQARVLFRSSPVELLAEIEPLPHRPDNSIEQACFRIAQESLTNVLRHARASQVQLQLRDVGKRGLHLQIRDDGEGFDPDGPRGLGLIVMRERAQSVGGHVRIESAHGEGTLIDVHLPYQAASMAAVDSPEY
>NZ_CP037858.1|WP_032127372.1|135600_137373_-|EAL-domain-containing-protein
MWNPNQPPVSIDDAPDRLGAGNPELQAMVAEAASGGTALMLMHVDIDHFASVNENMSAEVGDQALVLVAQRLQSYLRGRGKLWRHGSDEFLIAVPRTADVPLPEDFAEEIRQQMELPLSVLPYTLFMTGKLGVSLCPDHASSTSRLLDHAEDALYQAAREGGNAVRIHAVDTPPSAHSESIIARQIVDAIPNGELKLRYQPLVSARDGHVVGMEALLRWQSPTLGMLVPERFMRTAERLGIIVQIGTWVLEGALKQARLWRDQGFDDFTIAVNVSTLQLLRPNFFAEVMGLIQAAGVPAQMLTLEINESALTNNVNFVHETLANLRNEGISLSLDNFGTGDSSLSALVRYPVDKLKIDRSFIKSAPAGNREAAIARAIIAMGHQLGMTVIANGVESQAQLGFLRRNDCDVFQGYLFGEPMSADAAGMTLRRRYLRPEAFAETRPDRTLLLLDDEENVLRSLVRLFRRDGYRILAAGNVRDAFDLLAINDVQVILSDQRMSDMSGTEFLGRVKMLYPDTIRLVLSGYTDLNTVTDAINRGAIYRFLTKPWNDDELRKHIHQAFRTYEEQRRSNAGPAPVESGDGGEDRPLR
>NZ_CP037858.1|WP_142805928.1|134286_135507_+|sensor-histidine-kinase
MSAANALVTAPLPPQPVLQALLERLREGLLLFTEDGQVALANPAAQNLLAGGGEGSLPPPQRLRELLPPDALEQARQHGHWNGSLPLGEGVVIAHLYHHGPVGQGHFLALFRHIEGQEDYERELQQRHAELRQAYLRLNGTQEKLLQLEKMASIGQLAAGVAHEINNPIGYVHSNLGSLQEYLRSLFTVIEAYERALRAPDPKALIPEIDDIRDRLDIDFISRDLPQLMAESREGIERVTRIVRDLKDFSYSGRDESWKLVDLHAGLESTINIIWNELKYKVTLHREFGQLPLVECLPSELNQVYMNLLLNAGHAIAERGTITVRTGVDGDQVWVEFEDTGGGISPELRQRIFDPFFTTKPVGSGTGLGLSISYSIINKHHGRIDLDSTPGVGSRFRVVLPVKQPR
>NZ_CP037858.1|WP_006366325.1|133856_134195_+|flagellar-protein-FlgN
MTAAMSEPLQRLAQALDVERQALVEHDVHALIRATGAKLEALRALEGAPPVGEGEQLQELAERNRANGVLLSRRRREVNWALRQLGRTEDASAYDAKGQSHTVTARRPLAVA
>NZ_CP037858.1|WP_142805927.1|133554_133860_+|flagellar-biosynthesis-anti-sigma-factor-FlgM
MSQKIDGNLQVPQALRSVTTPASKPGVSSDSPARPVEAADSLRLTGEATNLQAIERGLTTAPAIDAQRVAAVRESLQNGTYKINPDAIASRMLDLDQQLQG
>NZ_CP037858.1|WP_099552268.1|132822_133479_+|flagellar-basal-body-P-ring-formation-protein-FlgA
MRRVTSLLAVALALASPWAAASDWQPVASIRAAALTTLPAGSEGEAQVADALRLPKCGGALQVQPTANTTVEVSCPDAGGWRLFVPVKVRRNQTVLVLNRGIGTGETLTAADITTAQRDAARIAGAVLADPNAAIGRIARRPLQAGALLSNNDLVVQRLIKRGDSVALVSRRGSVEVRIAGRAMGDAGENERVSVENLSSRRIVQGTVDAAGDVIVAR
>NZ_CP037858.1|WP_005409577.1|131617_132562_-|chemotaxis-protein-CheV
MSHDLLNRIDQRTRLAGHNRLALLLFRLGGRQLFGVNVFKVQEVLRRPELFQVPGLPSQFSGVADVRGRSVPVLDLGLAIGHPEREPEADTSPGYLVVTEFNRSIQGFLVSGVERIVNIAVEDIHPPPELGAESSYLTAVTRFQGELIQVIDVESVLADIAQVRGEAVLDPAMAMPSDGPQLQVLVVDDSRVARQQIRSVLDQLGVGATLLSDGKQALDHLLQIHASGENPAERYAMVISDIEMPAMDGYTLTTEIRRHPGLAGLYVLLHTSLSGVFNNAMVERVGANAFVAKYSPHELADFVLDRLRKVALAA
>NZ_CP037858.1|WP_099552270.1|131083_131479_-|flagellar-basal-body-rod-protein-FlgB
MRNLITDYLGVHAQAMPLREQRMKLIASNLGNADTPGYKAQDLDFDAALRHAQGLDANGLMATTHEQHYEISSGLNPFQIARDGVQPSLDGNTVDPDAERAAYGRAALEYRASLSFVESKVRSMLTAITGQ
>NZ_CP037858.1|WP_010485892.1|130672_131080_-|flagellar-basal-body-rod-protein-FlgC
MSNLPIFDIAGSALQAQSVRMSTIASNLSNADTVAGSADAVYKPLEPIFQAVTSKNDPNITSVKVKEITQSEAAPIKRYEPGHPLADGDGYIYQPDVDPVAQMVNLISTSRNYQAGVEMLTTAKELALATLTMGR
>NZ_CP037858.1|WP_142805931.1|143156_143504_-|hypothetical-protein
MSTTFMTWLGFAAMVFIAVTFTWRPAYATLRPPRHRPVAFLFGSLLFMLMAFLCAWMAATAINTGHVHLSHHRAGTIDAWRDIEPVTYWLIIVAAYVVGLMIASYSIAGIALMNR
>NZ_CP037858.1|WP_049446361.1|143601_143817_-|hypothetical-protein
MTLIRALPSLTDTERPRNASVREQLQQLEEVAREEIRELQQLADARPAPSRADEELLGLAWDLGLDGEALK
>NZ_CP037858.1|WP_142805932.1|143915_145070_-|chemotaxis-protein
MALTLLLPFAIGFEWPAALRWAILTTMTLSWLGFAWWTTRAQAHRSPEHARVLREQDQLLTELRNFVGNEIDGSRGEVERARDLIRQAVSSLGGSFDAMNRKSRQQSQALSRIVDRAGDEGNAGLDVARFAQHASHRMEQLVEALEQVSGQSSTTVQHIDQMAQHLDGIFALLEDVKSIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLSERSTTFNEQIRKLAHSSKDAIAKVRETVSHMASRDMDRSREARQEAAAMLDNVAQINASLGDGMREVSDCARSIDGSVAEAVRALQFEDIATQALGGVHTHLDRLTAINREAVALQELLHRNGGVFDEEIATALQRTGSRLRELRSEWERPPHKPVAQQSMGAGTVELF
>NZ_CP037858.1|WP_010485865.1|145325_145940_-|high-frequency-lysogenization-protein-HflD
MSFTVDDRVLALAGIAQALQQVRRIADTGHSDAAAVRTAVDSVFRVDASSPQEVFGDRHALKAGLRLLHNYFRSQGQDPILPKLALSVLQLERRFVQDGATVNKVASGIERAQRQATELGDSGHPDVLANLGGLYADTISHLKPRVMVQGNPHYLGQAGVVAEIRALLLAAVRSAVLWRQLGGSYWDFLFSRKAMIEAVDRQLA
>NZ_CP037858.1|WP_099552261.1|145936_147079_-|tRNA-2-thiouridine(34)-synthase-MnmA
MSTPRVMVGVSGGVDSSVAAWRLVQQGEAVAGLFMQNWADDGSGDCRAEDDRRDAVAVCGLLGIPFHFRDFSSEYWQGVFEHFLAEYAAGRTPNPDVLCNREVKFKHFLDAARELGAERIATGHYARVAQRGHQWLLLRGADRSKDQSYFLHQLGQEQLSATLFPIGDLEKTDLRRIARDVSLPTHAKKDSTGICFIGERDFREFLGRYLPAKPGQILDPADGSVIAEHPGVFYFTLGQREGLNIGGVRGRPAAPWYVVGKDVASNVLYVDQDRDSKWMLSDRLRSETAHWIAGSPPARRFECTAQTRYRQPDEPCTVEVLDDGSVLVTFARPQRAVTPGQSLVLYDGDVCLGGAVIAATDAPLEQRLRTTPSPFEVIAA
>NZ_CP037858.1|WP_142805933.1|147075_147537_-|NUDIX-domain-containing-protein
MNATPDPRWAPHATVATVVVDGGRVLLVEETIDGRQVLNQPAGHLEPGESLAEAALRETREETGWTVQLTHFIGCYQWTAGDGTTFLRFCYAARPVSHDPAQPLDTGIDRALWLTPAELQAAGDRQRSPLVWQVVADYLGGQRHPLSLVREVA
>NZ_CP037858.1|WP_111112597.1|147538_148009_-|hypothetical-protein
MKRTLLSTLLIALAASGSAAAADADKAVARHLDKLGYTYEVDEDGDYRMVFDVEGDRTQMVYVRSSVEDFGTHNIREIWSPAYSAKTKQFPVAVANRLLEDSQDAKMGGWVKQDTTAMFVVKIDADATADQLSDAIDAAIRTADAMELELTKKDEF
>NZ_CP037858.1|WP_005409592.1|148121_148448_+|ATP-dependent-Clp-protease-adapter-ClpS
MPHESSPDSQHEHGVAVEAARPEVAPPPFYQVMLLNDDYTPMDFVVDVLQQFFSMDLDKATQVMLHVHTRGRGVCGVFTREVAETKVAQVNEYSRMNQHPLLCTMEKA
>NZ_CP037858.1|WP_142805934.1|148554_149367_-|APH(6)-family-putative-aminoglycoside-O-phosphotransferase
MSEPYLSRWRLRRDGAAIDTPHARLWPVLTTAGEPAMLKISGETEEQNSHRLLRWWEGDGAARLLAHEGPAILIERAGGDSLRQRSIDGDDDACTTILCQVLQRLHRPRSAPPAELVCLRTWFADLLQPRAALPPLLEQCRSLAEGLLQDEQEIRPLHGDLHHDNVLDFGARGWLAIDPKRLLGDRAFDYTTLFSNPDLCGPGIHVATRPERFAARLEQVTALAELERTRLLRWIAASMGLSAVWFRDDGDPADIDETVARMALEALAEG
>NZ_CP037858.1|WP_099552257.1|149505_151791_+|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpA
MFSKDLEHTIGQCYKRAREARHEFMTVEHLLLALLDNPSAQAVLKACGADAERLRQELEQAIEASVSRLAEDDGRDTQPTLGFQRVLQRAVYHVQSSGKKEVTGANVLVAIFGEKDSHAVYYLNQQDVTRLDVVNYLSHGIAKLGEEGEQPSSSSEGEGRIEGGEGEPKGDALTEFASNLNEQARAGRIDPLVGRADEIERTIQVLCRRRKNNPLYVGEAGVGKTAIAEGLARRIIEGSVPDVLADAVIYSLDLGALVAGTKYRGDFEKRLKSVLTALKKVPNAVLFIDEIHTIIGAGSASGGTMDASNLIKPALASGELRCIGSTTFQEYRGIFEKDRALARRFQKIDIVEPTVGETYEILQGLKSKYELHHGVTYSDEALQAAVDLSVKHIGDRLLPDKAIDVIDEAGARQRLLPEGQRKELIDVEEVEAIVAKMARIPAKQVSATDKDVLQHLERNLKMVIFGQDPAIETLSSAIKLARSGLGNPEKPIGNFLFAGPTGVGKTEVTKQLALQLGIELVRFDMSEYMEPHSISRLIGAPPGYVGFDQGGLLTEKIVKTPHCVLLLDEIEKAHPDIFNILLQVMDRGVLTDTNGREANFKNVVLVMTTNAGAAQASRRSIGFTKQDHATDAMETIRRSFTPEFRNRLDAVVQFQALGFEHILRVVDKFLIELEMLLQDKHVSLSATPTARDWLAHHGFDPLMGARPMARVIQDKIKRPLADELLFGKLVNGGKVSIDVRDDELVVETQAEPERLLPVTVE

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Crispr_ID: NZ_CP037858_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_2

1283258-1283362

Orphan

Consensus_repeat	Method
CGGTAGTGCCGGCCGCTGGCCGGCAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP037858_2

>merge|NZ_CP037858|2|1283258-1283362|CRISPRCasFinder
CGGTAGTGCCGGCCGCTGGCCGGCAATGCCAACCAAGGTTGGCCTCTACCAGAGCCGGGCCATGCATGTGAACGCAGGCGGTAGTGCCGGCCGCTGGCCGGCAAT

>NZ_CP037858|2|2|1283258-1283362|CRISPRCasFinder
CGGTAGTGCCGGCCGCTGGCCGGCAAT	GCCAACCAAGGTTGGCCTCTACCAGAGCCGGGCCATGCATGTGAACGCAGG
CGGTAGTGCCGGCCGCTGGCCGGCAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_010482785.1\|1283649_1284513_-\|protease-modulator-HflC	unknown	unknown	gnl\|CDD\|259803
NZ_CP037858.1\|WP_005410640.1\|1283396_1283582_-\|DUF2065-family-protein	unknown	unknown	gnl\|CDD\|225782
NZ_CP037858.1\|WP_099555336.1\|1289014_1289590_+\|bacterioferritin	unknown	unknown	gnl\|CDD\|225104
NZ_CP037858.1\|WP_142806541.1\|1279398_1280358_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|341130
NZ_CP037858.1\|WP_049429965.1\|1272399_1273122_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP037858.1\|WP_142806539.1\|1274861_1276985_-\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|185001
NZ_CP037858.1\|WP_142806540.1\|1277056_1279222_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369473
NZ_CP037858.1\|WP_142806542.1\|1280362_1281019_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_CP037858.1\|WP_142806547.1\|1292135_1297043_-\|alpha-2-macroglobulin-family-protein	unknown	unknown	gnl\|CDD\|225248
NZ_CP037858.1\|WP_142806545.1\|1285796_1286792_+\|acryloyl-CoA-reductase	unknown	unknown	gnl\|CDD\|176183
NZ_CP037858.1\|WP_142806536.1\|1273227_1273644_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NZ_CP037858.1\|WP_099555338.1\|1288502_1288985_+\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239311
NZ_CP037858.1\|WP_142806544.1\|1281734_1283027_-\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NZ_CP037858.1\|WP_142806546.1\|1289704_1292086_-\|penicillin-binding-protein-1C	unknown	unknown	gnl\|CDD\|227289
NZ_CP037858.1\|WP_099555340.1\|1287350_1288241_-\|DnaJ-domain-containing-protein	unknown	unknown	gnl\|CDD\|182347
NZ_CP037858.1\|WP_142806543.1\|1280954_1281617_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_005410642.1\|1284509_1285643_-\|FtsH-protease-activity-modulator-HflK	unknown	unknown	gnl\|CDD\|130988
NZ_CP037858.1\|WP_142806537.1\|1273653_1274355_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225176
NZ_CP037858.1\|WP_005410644.1\|1286880_1287252_+\|response-regulator	unknown	unknown	gnl\|CDD\|381093
NZ_CP037858.1\|WP_142806538.1\|1274487_1274775_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_010482785.1\|1283649_1284513_-\|protease-modulator-HflC	gnl\|CDD\|259803	cd03405, SPFH_HflC, High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prokaryotic HflC (High frequency of lysogenization C). Although many members of the SPFH (or band 7) superfamily are lipid raft associated, prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this SPFH domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflC is an integral membrane protein which may localize to the plasma membrane. HflC associates with another SPFH superfamily member (HflK) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.	1.55824e-106
NZ_CP037858.1\|WP_005410640.1\|1283396_1283582_-\|DUF2065-family-protein	gnl\|CDD\|225782	COG3242, COG3242, Uncharacterized protein conserved in bacteria [Function unknown].	1.95241e-11
NZ_CP037858.1\|WP_099555336.1\|1289014_1289590_+\|bacterioferritin	gnl\|CDD\|225104	COG2193, Bfr, Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism].	8.67521e-35
NZ_CP037858.1\|WP_142806541.1\|1279398_1280358_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	2.75827e-27
NZ_CP037858.1\|WP_049429965.1\|1272399_1273122_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.37525e-24
NZ_CP037858.1\|WP_142806539.1\|1274861_1276985_-\|HAMP-domain-containing-protein	gnl\|CDD\|185001	PRK15041, PRK15041, methyl-accepting chemotaxis protein.	2.22138e-78
NZ_CP037858.1\|WP_142806540.1\|1277056_1279222_+\|hypothetical-protein	gnl\|CDD\|369473	pfam07705, CARDB, CARDB. Cell adhesion related domain found in bacteria.	5.34993e-10
NZ_CP037858.1\|WP_005410642.1\|1284509_1285643_-\|FtsH-protease-activity-modulator-HflK	gnl\|CDD\|130988	TIGR01933, Protein_HflK, HflK protein. HflK and HflC are paralogs encoded by tandem genes in Proteobacteria, spirochetes, and some other bacterial lineages. The HflKC complex is anchored in the membrane and exposed to the periplasm. The complex is not active as a protease, but rather binds to and appears to modulate the ATP-dependent protease FtsH. The overall function of HflKC is not fully described.//Regulation of FtsH by HflKC appears to be negative (SS 8/27/03].	8.29771e-117
NZ_CP037858.1\|WP_142806547.1\|1292135_1297043_-\|alpha-2-macroglobulin-family-protein	gnl\|CDD\|225248	COG2373, COG2373, Large extracellular alpha-helical protein [General function prediction only].	0
NZ_CP037858.1\|WP_099555340.1\|1287350_1288241_-\|DnaJ-domain-containing-protein	gnl\|CDD\|182347	PRK10266, PRK10266, curved DNA-binding protein.	1.93255e-74
NZ_CP037858.1\|WP_142806536.1\|1273227_1273644_+\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	3.50564e-11
NZ_CP037858.1\|WP_142806544.1\|1281734_1283027_-\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NZ_CP037858.1\|WP_142806546.1\|1289704_1292086_-\|penicillin-binding-protein-1C	gnl\|CDD\|227289	COG4953, PbpC, Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane].	0
NZ_CP037858.1\|WP_142806542.1\|1280362_1281019_+\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.48334e-24
NZ_CP037858.1\|WP_142806545.1\|1285796_1286792_+\|acryloyl-CoA-reductase	gnl\|CDD\|176183	cd05280, MDR_yhdh_yhfp, Yhdh and yhfp-like putative quinone oxidoreductases. Yhdh and yhfp-like putative quinone oxidoreductases (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.73842e-165
NZ_CP037858.1\|WP_142806537.1\|1273653_1274355_-\|alpha/beta-hydrolase	gnl\|CDD\|225176	COG2267, PldB, Lysophospholipase [Lipid metabolism].	5.39542e-07
NZ_CP037858.1\|WP_005410644.1\|1286880_1287252_+\|response-regulator	gnl\|CDD\|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.3106e-35
NZ_CP037858.1\|WP_099555338.1\|1288502_1288985_+\|peroxiredoxin	gnl\|CDD\|239311	cd03013, PRX5_like, Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 suggests that it may have an important antioxidant role in organelles that are major sources of reactive oxygen species (ROS), as well as a role in the control of signal transduction. PRX5 has been shown to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite. As with all other PRXs, the N-terminal peroxidatic cysteine of PRX5 is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Human PRX5 is able to resolve this intermediate by forming an intramolecular disulfide bond with its C-terminal cysteine (the resolving cysteine), which can then be reduced by TRX, just like an atypical 2-cys PRX. This resolving cysteine, however, is not conserved in other members of the subfamily. In such cases, it is assumed that the oxidized cysteine is directly resolved by an external small-molecule or protein reductant, typical of a 1-cys PRX. In the case of the H. influenza PRX5 hybrid, the resolving glutaredoxin domain is on the same protein chain as PRX. PRX5 homodimers show an A-type interface, similar to atypical 2-cys PRXs.	1.322e-77

>NZ_CP037858.1|WP_142806544.1|1281734_1283027_-|adenylosuccinate-synthase
MGQSVVVLGAQWGDEGKGKIVDLLTEEIGAVVRFQGGHNAGHTLVINGKKTVLHLIPSGILRDDALCLIGNGVVISPAALQKEIAELEASGVEVRSRLKISPAAPLIMPYHIALDQARERAAGGKAIGTTGRGIGPAYEDKVARRGIRIADLHYPKQLEELLRTALDYHNFVLTKYLNTDAVDFQKTFDEALAFGEYVQPMKSDVAGILHDLRKQGKRVLFEGAQGALLDIDHGTYPYVTSSNTTVGGALAGSGVGADSIDYVLGIAKAYATRVGGGPFPTELDDEVGQGIRDRGAEYGASTGRPRRCGWMDIVALKRAVAINGISGLCITKLDVLDGMEKLKVCIAYEYNGKRTEYAPLDAQGWEECTPVYLEFPGWSENTHGITHWDDLPPAARAYLRSLEELAGCPISIVSTGPDRDHTMVLQDPFA
>NZ_CP037858.1|WP_142806543.1|1280954_1281617_-|hypothetical-protein
MKGMTVIRITLWVFWSLWGIACLVLVLGAAANTLASRTQTVPLVLTPGATAQFTVYRLIDDQLRLRLRYAADGTEADPEVLLRIETPTDHGDFRAGERSGVAGQGINRRLASVESSGLMASYFGYGRGDALPRGRSWLRVTVLEVDPALAGHPADIELQPPLDLLKLTDLDYLWLWPFFFWKMAALFLLIPGAALAVLTITLRRWQRGASKQPISAGDRD
>NZ_CP037858.1|WP_142806542.1|1280362_1281019_+|peptidoglycan-DD-metalloendopeptidase-family-protein
MRLSQLIVLGVLLGLGAGWWLRRDAGEPVAVAQPAVQPAVAAAATPRVDGPAPTAVPPSNATDAPAGLLLPVQGIPASQLRDTFTDARSEGRVHDAIDIMADAGTPVLAVADGTVEKLFDSERGGLTIYQFEPSGRWCYYYAHLQRYADGLAEKQVIKRGDVIGYVGSTGNASAEAPHLHFETHVLGAEKQWWKGESINPYPLLKSAASTPHAASAAR
>NZ_CP037858.1|WP_142806541.1|1279398_1280358_+|L,D-transpeptidase-family-protein
MRVPHPVLFVLSLLISPAFAQSPAPAHLPAPIAETAGPDTAPRSALHAQVLLDRANFSPGQIDGEVGSNQRRAVSGFQAARGLPVTGELDDATWKALQADTITPLASYTLTAEDVAGPFQATPKGPAAQAKLKSLGYGSVEEALGERFHASPELMKVLNPGVDLTRAGSRIQVPNIAAAALPKAARVVVDKSNSTLQLLDAQGKLIAQVPVSSGSQHDPLPIGEWKILGVYRDPPFHYNPKLFWDARKGEKKATLPPGPNNPVGRVWIDLSKPHYGLHGTPEPGHVGKTESHGCVRMTNWDALRVADAVDTTVPVVMQE
>NZ_CP037858.1|WP_142806540.1|1277056_1279222_+|hypothetical-protein
MLRARFTFAPSLPATNAQHLRRRSDPRGCCRYAGPPLICTMPDLGHPRHRTRTTMRHYLSALPLLLACMTSPQSAHAQDAYTGSNFKFLYAYNIIGNAEPAVRSQLTELHNAGANVIPVTGWNTGELSSRLQALRQDPLLSRFKVLLQFNGPVHDAWYADPGSACSPGNERLPDWLQQELDAVAALALQNSDIVVGYYTFDEPALPQTPQNLGICKRFQELVYERLRQADPDASARPVIIANLMGTLSDAQIQYAMSPHAQDVVFVDQYQNTVNEQVTQYQKWKRHGLLGGGMVPVLPAFNYTSCNDPGLRSSFRAKLEAALQAVYGADRPRNLGSAYFAFWPGARPDFQFDGQNCPAIFNSMIDDLSHQPDLQVTRIDTIPSQFRAGEPVRFRANIRNVGNAPSPMNHHSVLVHEEGRCFDGGCQWGILTTSLAPGQQATIDLNQGPSWIPSAGLHAVTVFADDADRIKELDEHNNELTREIMVGDLPDLQPYLIETIPASFKPGDAVTFRTAVTNRGSMPAPAGWLGAVYLVNGACPASGCPWSGLTTALAPGESVWLSPTGPVWPAAGGQQQITSIVDDQGLIQESNEGNNQLARIIQVSDKPDLRITSAHSQPLRPKSGDATSFTATIENVGSVAASAPWIGLMAMKNGQCFIEGCVWGGLQNYTLAPGASVNVRTYNDVWRPTAGVHSIQLLVDDQNTVSESREDNNSIDITVTVD
>NZ_CP037858.1|WP_142806539.1|1274861_1276985_-|HAMP-domain-containing-protein
MNYLRNVRVAWRLGLGFGLLLLLVAAVVATGATASVVQKRAMQQVVDVSVAKVRLLSQMLDANNQMMVVRREMLIRQGDDRGHDEQRIADLVKRYEASWSAYQALPSDADGKAIAETIAAKRAIARPLNKQTSELMEQGDYPGAVALTLGPVQDAANGWNKALSDGVDFEEKESRDAAAEAIRLGERSLLQLLVLGGVALLVGIGASVMIGRSLTGPLARAVNLAERLSKGQLDQEFRLGGRDELTQLGEAMASVRQSVQAAIGAQLQMAEQHEAGAIRYRMDVTAFPGDFGRMVQATNSLVESHVQVELLMAEVMQRYAIGDLSRDLPDYPGEKGTLTRTLAAVKQSLMSINAQIDELARAARAGDFSMRGDAAAFQYQFKAMVEHLNGMMASSQASIADVSDVLRAISHGDLTARMDGEYDGVFARMRDDANTTTAQLTGIVRGIQVAADSINNAAQELAAGNNDLSRRTEQQAANLEEAAASMEELTSTVRQNAELARQADSEAHAAGAAVRETEQAMAQMASVMGEIDQSSARISEISTVIDGIAFQTNILALNAAVEAARAGERGRGFAVVASEVRTLAQRAGVAAKEIKELIEDAAAKVKSGLAVTVESEAAIARVAQASSRTTQLMSDIAAASKEQAAGIEQVNQVVVQMDQVTQQNAALVEEATAASRALEEQAHALTTSVAVFKVEGAAASAVTRRAA
>NZ_CP037858.1|WP_142806538.1|1274487_1274775_+|hypothetical-protein
MRKPRWLSWTGIAICTLYLALTAWLVLDAQANSDPKSAYILMQLPVMLQTAALDVIGMGGWLSGKTWTTVYLLVMPPTLAVLYAVGAMLGSVLEQ
>NZ_CP037858.1|WP_142806537.1|1273653_1274355_-|alpha/beta-hydrolase
MNAAMLRVVMLPGLDGTGLLSAHFVEAMQARGIQMQVLPMPARGPQDYTTLASILRPQLPASPFVLLAESFAGPLAIELAVAGLPGLHGLVLSTTFARRPVPLPAASARILAPAWPLPPLALMARLLLGQWRTRANLRELGLAIMQVPAATLRQRAATTLQVDVRALLPELVLPTLCLHARQDRLLWPPSVAELQALLPDARHVSLEGPHLLLQARADAAAAEVAAWVRALPP
>NZ_CP037858.1|WP_142806536.1|1273227_1273644_+|hypothetical-protein
MPRGDKSTYTEKQKRQAEHIEDSERERGASESTAERIAWATVNKQDGGGKRSGSGRKVAKKAPAKKAASKAAAKTTTAKKAPARKTATKKATRKTVAKKASTPASRSAAAKKAAKTRAAKKTVRKVAAKKAARTRARG
>NZ_CP037858.1|WP_049429965.1|1272399_1273122_-|AraC-family-transcriptional-regulator
MRVEPADIEALFDAIPDVLFFIKDLQGRYTHVNQTMLRRLGLRARKDVIGRTAAEIYPTGLSADYVDQDARVLSGEVIENLMELHLFANREPGWCLTCKRPLVVDGAIEGLIGISRDLGQKDSLGTQYEQLRLALAHLNAHYAENVRMQTLLDITGFSLSKLERSFRKVFQMTPQQVLTRLRIQMAMHLLHGDESIASIGQACGFSDQSAFTRKFKAETGFSPRAYRARIGGNVGEPALA
>NZ_CP037858.1|WP_005410640.1|1283396_1283582_-|DUF2065-family-protein
MKDLFAAVCLVAVLEGLFLFVAPFAWKRMAERLLDLPSPALRSFGGLVLLAGLSLLWWARH
>NZ_CP037858.1|WP_010482785.1|1283649_1284513_-|protease-modulator-HflC
MKSPIWIAVIVAVVLGLLGSVYVVREDQTAMVLNLGKVVRSDIKPGLHFKVPVVETVKVFDRRFQVLDTAPARYFTAEQKDVSVDFFAIGYISNVGDYFRATGGDPRIANARLAPIITDSLRNQINSRTLQQLVSGDRSELIAEQLKGINEAVAGLGMQMIDLRIKQVDLPTDSQVINDVYERMRAQRKQEAAKLRAEGEEQSLTIRAQADRDSTVLIAEAERDAQRLRGEGDADAARIYGKAGSADPSFYAFYRSLEAYRGSMTDGNGVIVLDKNDPFLQYLKNDR
>NZ_CP037858.1|WP_005410642.1|1284509_1285643_-|FtsH-protease-activity-modulator-HflK
MAWNTPGGNKGGQGPEDNRRGPFGSRGGGNGGGWGGLPGPLKDLFDGGIVRWVVAAVVLLVLFSSFQLIGEQQRGVVLRFGQFSRILQPGPNFKLPWPIESVTKVNATEIKTFSIQVPVLTRDENIVNVSLNVQYRIDDPQQYLFGTVDANQVLEQSAQSAVREEVGRADLNAVLNNRGPLAVAAEERLQALLKAFKTGLTVTGLTLQDARPPEEVKPAFDEVNGAQQVKERLINEAQAYAAKVVPEARGQASRARTTAEGYKQAVVSKAEGDAQRFSLLQAQYKDAPEVTRKRLWLETVQQVLSENRKVIGGDGRQLIYVPMTGDTRPSTSAPAAVANPDVVMPSLPGAAAEASRDPGRPVGRPTGRPSGREEGSR
>NZ_CP037858.1|WP_142806545.1|1285796_1286792_+|acryloyl-CoA-reductase
MAPTTPFTAFRIENDDAGYRSGLAQLGVDDLNPGQVLIRAHWSSVNYKDALAGTGKGKILRRFPLVGGIDVAGTVVASTDPDWREGDAVLATGCGLSETRDGGYSQYVRLESRAVIAQPAGLTPREAMVLGTAGFTAALALLRMQDNRQTPELGPLAVTGASGGVGALALSIFSRAGYSVHAVSGKPDQTDFLHAIGATEVLPRDALSDTGPLQSARFGGGLDNAGGDMLASLLAQTVPYGSVVSAGLAASPTLDMTVMPFILRGVSLLGVSSANAPRGLREEVWSRLGSDWKPQQLDRICTAEVGLDGLPAVFERMLAGGSLGRTVVRID
>NZ_CP037858.1|WP_005410644.1|1286880_1287252_+|response-regulator
MARILIVDDSPSQLLGIQRIVEKLGHQILTATDGAAGVETAKAELPDLVLMDVVMPNLNGFQATRTLARDEATRHIPVILVTTKDQDTDRMWGMRQGAKAYITKPFSEDELSEVLERVFAGQG
>NZ_CP037858.1|WP_099555340.1|1287350_1288241_-|DnaJ-domain-containing-protein
MEFKDYYATLGVEPSAGEAEIKTAYRRLARKYHPDVSKEAGAEDKFKAVNEAYEALRDPEKRAAYDQLRAQGYRPGEEFNVPPNYGGAGGFNFEEVFGGGGPNGGFSDFFESLFARQRGGGAGPGPGFSSQGHAPNRDTRAKLSVPLEAAYSGDSLRITVNGKQLDVRVPKGIRPGQVIRLAGQGNHGGNLLLEVEYAAHPQFEVDGRNILYTLPVTPWQAALGTSISVPTLGGAVELKIPADSDAGRKLRLRGRGLPGNPDGDQIVEIEIVAPAATDEAQKKAYRNLAKAFGESI
>NZ_CP037858.1|WP_099555338.1|1288502_1288985_+|peroxiredoxin
MTIHVGDRIPEVTLKRIREGIETLDTHSLFDARKVVLFAVPGAFTPTCSARHLPGYVEKFQAFRQRGIDVYCVAVNDPFVMKAWAADQNVPDGLLMLSDGNAELTRALGLELDASASGMGIRSRRFALYVVDGVVRAAWVEQPGQFEVSSAEYVLEHLPT
>NZ_CP037858.1|WP_099555336.1|1289014_1289590_+|bacterioferritin
MSSKPAKASKPAARIPGISDRKTLRDRARRNIEDGAITDSYSADRKVVIKLLNDALATEYVCVLRYYRHYFMAKGMLADAVKAEFLEHAQQEQAHAGKLAERIVQLGGEPDFNPDTLTTRSHAEYKEGSDLRDMVRENLVAERIAIDSYREMINFIGDRDTTTKRILEEILAQEEEHADEFADLLDGWIGE
>NZ_CP037858.1|WP_142806546.1|1289704_1292086_-|penicillin-binding-protein-1C
MKDAMKTRLAALRRRLRPLWPWLRWGTAATLALLLVLDLAFPPPLPKQRDTSTLVVSADGTPLRAFADAEGVWRYPASVDSVSPLYLQALLTYEDRWFWRHPGINPLAILRASGQLLRGGRIVSGGSTLTMQVARILDPHTRTPWGKLKQMLRAVQLEVHLSKRQILALYLERAPYGGTIEGVEAASWAYLGKPAAQLSHAEAALLAVLPQAPSRLRPDRHPEAAQRARDKVLSRMAELGAWTPEEVEDARIENVVARSLRPPLHAALLAQRLHSAHPGQARIQSSIDIGLQRTLEERVASYFSTLPERTSAALLVIDNQTLQARAYVGTLSFGDRQRLGHVDMVQAWRSPGSTLKPFLYAMALDDGLIHSESLLVDAPQSFGSYRPGNFDMAFNGPIGASSALRLSLNVPSVDLLQRVGAARFAARLSHAGIQLRFPPGSTPNLSLILGGTGARLEDLVGAFAALNRNGIAGRVRYTDDEPMIERRLASPGASWIVREMLESNPRPGYSIGTFDVGARPRVAWKTGTSYGYRDAWAIGSTRHYTVGVWVGRPDGTPLPGQYGAVTALPLMFEVVDSLPRQRGDSAAAPMPASVSQEDVCWPTGERAEGLPASLCQRRMPAYLLEGAAPPTFPEREARRWQPGRQRYLADARTGLRVSADCRLPHEEVAREIARWPALLSPWLSKATRDASQLPALSPDCRDDGREASVALHIDGLNDGAALARAPNADHGVRLQLRALGSEQGVDWLLDGRWIAQTHGAQLMQREFAEPGAHTLTALAADGAWTQVRFNVLR
>NZ_CP037858.1|WP_142806547.1|1292135_1297043_-|alpha-2-macroglobulin-family-protein
MSGPARRKRWGWAAAVLAGGLLLGLAGCRNDSGQLPKASGEAITTKAEQVKEFTLLRAYPDQKNDGLSLALEFSRPLVGTQDFDKLVRFEEKVGTDDSSWTLSDDGLTLRYPFVEAGKEFSLVVSPDLLAADGSRLGKELKQKVFSGELKPVVGFASQGSVLPAKDSRGLPVVSVNVPEVDVEFLRVREKDLPTFFSQYQRGGRRGSWELSSDYERSPINKLAEPVYVNRFILGGKKNERVLTYLPTQDIKELQEPGLYFALLKRTGDYEGEFDTAFFSVSDIGLHTRAYKDKLFVHTAGLKDGAPLKGIDLRVLDAKGEVVLKGSTDGNGNALLNYTLDATHVLVASSGKDTSFLPFNQPALDLSEFAVAGRDNAWFDVYAWSGRDLYRPGETVRLSALLRDNDGKPVKAQPVFLRLKQPDGKTFRETRLQPGEQGYINFEQVIPAEAPTGRWQVEFRTDPASKEAIQGMTLRIEEFLPERMKLDLDSAQKTLKPGEDLRLQANGAYLYGAPADGNRFTARMAVAAEQRPVEGLPGYFFGDPTLQLPREAKDVVDTTLPGNGQLREDVALPEEAAKAKAPIAVVLSGSLYETGGRTVTRTLKRVMWPANALVGVRPLFNPEDGADSNGNARFELMRVDAAGTPQPAKGLKITLVRELRDYHWTFNDNRWDYDFTRRFENKETRTVDAGSSAVAFDFPVEWGEYRVDVFDPSTGLTSRYPFRAGWSWGDDNRGLDARPDKIKLGLDKTGYKAGDTLEVTVTPPHAGKGILMVETDRMLYVQDIEAKPGSTFRIPVTADWERHDVYITALVFRGGSAPSKITPARAVGVVHVPMDRKGRTVAVGLAAPKQMRPEQDLPVTVSAPQLAGKMAHVTVSAVDVGILNITRFPVPDAGAHFFAQRRLGIDAYDIYSRVIESFDGGAGKLKFGGDMALQALPQAKRPTARVQTVDLFSGPVQLDAKGIARIRLKVPDFNGTLRVSALVYSDDQYGKRDVETVVRAPILAEASMPRVLAPGDRSTVTLDVQNFTGKPGQFNVKVDTEGPLTLGEGSRSVQLNADAKTTLSFPLSAREGHSVAKVRVRVDGNGFKADRRYDLPVRAAWPQVLRSQVRTLDPLAAVSLDNSLTEGLMSESVNARLLVSPLPPIPFASALQGALNYPYGCAEQTTSKGYAALILDQATSSMLGADGLDAKARRERMEGAFGRLASMQVANGNFSMWGDDGYVNPWLTPYVTEFLLDAKDAGFAVPDNVLQKALNRLSEDLLSGGNQFYGQDDREKLTFSNKAYSGYVLARVNRAPLGTLRALYDNERSKAVGGLSLVHLGVALSLQGDAKRGQAALAAAFAKSSSERPSYFGDYGSAIRDDALMIALTHENKLAKPAWDARAVDLGRGLDARRSAGWMWLSTQEQVAIARLGKALAANQKALVAGELVIGGNSESVGERKLFGRNFTASELASGVRFTPQGQPPMFASIDVAGIPRSAPAPDNSVLGIERSYYGTDGKPWSPRPLKEGEALIVRVTVTADTTMPDALLTDLLPAGLEIENFNLGDAKQWADVVVDGITISDRGEAADTKHEEFRDDRYVAALKLSRGSKANVFYLVRAVTPGTYSVPPPLVEDMYRPQLRGVGRSNPTTITVVQP

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Crispr_ID: NZ_CP037858_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_3

1472479-1472579

Orphan

Consensus_repeat	Method
GCCATCCACGCATGGCGTGGATCTACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP037858_3

>merge|NZ_CP037858|3|1472479-1472579|CRISPRCasFinder
GCCATCCACGCATGGCGTGGATCTACCCACCAACGTGGTAGTGCCGGCCGCTGGCCGGCAACCTCATGCATCGCGCCATCCACGCATGGCGTGGATCTACC

>NZ_CP037858|3|3|1472479-1472579|CRISPRCasFinder
GCCATCCACGCATGGCGTGGATCTACC	CACCAACGTGGTAGTGCCGGCCGCTGGCCGGCAACCTCATGCATCGC
GCCATCCACGCATGGCGTGGATCTACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_142806626.1\|1475095_1475533_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|227304
NZ_CP037858.1\|WP_142806620.1\|1460920_1461691_-\|peptidoglycan-editing-factor-PgeF	unknown	unknown	gnl\|CDD\|182677
NZ_CP037858.1\|WP_142808074.1\|1475885_1477145_+\|type-II-secretion-system-F-family-protein	unknown	unknown	gnl\|CDD\|224376
NZ_CP037858.1\|WP_099553741.1\|1478736_1480104_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP037858.1\|WP_005410804.1\|1480066_1480744_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP037858.1\|WP_142806622.1\|1465140_1466775_-\|NAD+-synthase	unknown	unknown	gnl\|CDD\|237577
NZ_CP037858.1\|WP_005410807.1\|1482035_1482914_-\|30S-ribosomal-protein-S6--L-glutamate-ligase	unknown	unknown	gnl\|CDD\|182468
NZ_CP037858.1\|WP_142806628.1\|1481312_1481789_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_099553743.1\|1480752_1481223_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_099553729.1\|1469379_1470993_+\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP037858.1\|WP_005410793.1\|1466955_1467831_-\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
NZ_CP037858.1\|WP_049429911.1\|1477152_1478016_+\|prepilin-peptidase	unknown	unknown	gnl\|CDD\|224900
NZ_CP037858.1\|WP_142806625.1\|1474535_1474943_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|227304
NZ_CP037858.1\|WP_004154430.1\|1467852_1469022_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813
NZ_CP037858.1\|WP_142806621.1\|1461690_1462680_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	unknown	unknown	gnl\|CDD\|183020
NZ_CP037858.1\|WP_024956778.1\|1462793_1463681_+\|outer-membrane-protein-assembly-factor-BamD	unknown	unknown	gnl\|CDD\|274513
NZ_CP037858.1\|WP_142806623.1\|1471053_1472427_+\|response-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP037858.1\|WP_099553720.1\|1460393_1460900_-\|DUF4166-domain-containing-protein	unknown	unknown	gnl\|CDD\|379359
NZ_CP037858.1\|WP_142806627.1\|1478027_1478639_+\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|234620
NZ_CP037858.1\|WP_099553725.1\|1463876_1465067_+\|lipase	unknown	unknown	gnl\|CDD\|367570

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_142806626.1\|1475095_1475533_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|227304	COG4969, PilA, Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion].	9.05822e-18
NZ_CP037858.1\|WP_142806620.1\|1460920_1461691_-\|peptidoglycan-editing-factor-PgeF	gnl\|CDD\|182677	PRK10723, PRK10723, polyphenol oxidase.	1.35228e-85
NZ_CP037858.1\|WP_142808074.1\|1475885_1477145_+\|type-II-secretion-system-F-family-protein	gnl\|CDD\|224376	COG1459, PulF, Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion].	1.9418e-151
NZ_CP037858.1\|WP_099553741.1\|1478736_1480104_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.8802e-50
NZ_CP037858.1\|WP_005410804.1\|1480066_1480744_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.28625e-73
NZ_CP037858.1\|WP_142806622.1\|1465140_1466775_-\|NAD+-synthase	gnl\|CDD\|237577	PRK13981, PRK13981, NAD synthetase; Provisional.	0
NZ_CP037858.1\|WP_005410807.1\|1482035_1482914_-\|30S-ribosomal-protein-S6--L-glutamate-ligase	gnl\|CDD\|182468	PRK10446, PRK10446, 30S ribosomal protein S6--L-glutamate ligase.	9.43308e-126
NZ_CP037858.1\|WP_099553729.1\|1469379_1470993_+\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	4.57299e-38
NZ_CP037858.1\|WP_005410793.1\|1466955_1467831_-\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
NZ_CP037858.1\|WP_049429911.1\|1477152_1478016_+\|prepilin-peptidase	gnl\|CDD\|224900	COG1989, PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	4.24637e-59
NZ_CP037858.1\|WP_142806625.1\|1474535_1474943_-\|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl\|CDD\|227304	COG4969, PilA, Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion].	5.28296e-19
NZ_CP037858.1\|WP_004154430.1\|1467852_1469022_-\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP037858.1\|WP_142806621.1\|1461690_1462680_-\|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD	gnl\|CDD\|183020	PRK11180, rluD, 23S rRNA pseudouridine(1911/1915/1917) synthase RluD.	2.72295e-147
NZ_CP037858.1\|WP_024956778.1\|1462793_1463681_+\|outer-membrane-protein-assembly-factor-BamD	gnl\|CDD\|274513	TIGR03302, OM_YfiO, outer membrane assembly lipoprotein YfiO. Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking].	2.53346e-90
NZ_CP037858.1\|WP_142806623.1\|1471053_1472427_+\|response-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	0
NZ_CP037858.1\|WP_099553720.1\|1460393_1460900_-\|DUF4166-domain-containing-protein	gnl\|CDD\|379359	pfam13761, DUF4166, Domain of unknown function (DUF4166). This domain is often found at the C-terminus of proteins containing pfam03435.	7.79979e-22
NZ_CP037858.1\|WP_142806627.1\|1478027_1478639_+\|dephospho-CoA-kinase	gnl\|CDD\|234620	PRK00081, coaE, dephospho-CoA kinase; Reviewed.	1.95689e-86
NZ_CP037858.1\|WP_099553725.1\|1463876_1465067_+\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	0.000300117

>NZ_CP037858.1|WP_142806623.1|1471053_1472427_+|response-regulator
MNETRSALVVDDERDIRELLVLTLGRMGLRISTAANLAEARELLASNPYDLCITDMRLPDGNGIELVSEIAQHYPRTPVAMITAFGSMDLAVEALKAGAFDFVSKPVDISVLRGLVKHALELNNAERPAPSPNAEQGGRLLGHSQAMDVLRTTIGKVARSQAPVYILGESGVGKELVARTIHAQGARAAGPFVPVNCGAIPGELMESEFFGHRKGSFSGAHADKPGLFQAAHGGTLFLDEVAELPLQMQVKLLRAIQEKSVRAVGAANEEPVDVRILSATHKDLAELVEDGRFRHDLYYRINVIELKVPPLRERRQDLPELAAAVLARLARSHGRATPLLAPSALEALAQYAFPGNVRELENILERALALAEEDCIGADDLRLPQHAPRAPGSAAPAEAVADLQPGSAALPSYIEQLERSAIQRALEENRWNKTRTAAQLGITFRALRYKLKKLGME
>NZ_CP037858.1|WP_099553729.1|1469379_1470993_+|PAS-domain-containing-protein
MSPSASLIDRIESIPRRELYFFALYRVLIATVIAALLYSPLSAMVGEAHHPRLADVVAVIYLALSLLALALGRNERWLRPIVVSGVLVDIVAATLLSHALPGASAGISMSLLFNIAAAATLLPLSLGLGLALAASLATGVEYTWKLLEGGDPTRTLAELAMFATSYLALAFISYQVGNRARRNQQLANQRGDEVANLFQINELIIRRMRTGVLVVDADNRITLANEAASMLLGDNDGNGESGRLDLASAAPELARRLQRWRNGWAQDELPLQLNPDQPEVQPRFARLLAGSELALVFLDDSSVVSRRAESLTLSAMGRFSASLAHEIRNPLAAINYAVQLLEEGTGFNESDRRLLQIIRQQCQRTNGIVESVLGLARRERATPENVDLVAFVRRFVLEYKQGQTLETDSIEPIISDTSVMAQVDTKHLYQVLTVLVHNALKYGRIGQQPARVRLRVAQHERSAVIDVMDRGPGIPESVAAQLFRPFFTTSEHGTGLGLYIARELCRANQARLDYIAVPAGGSCFRLVLPGPHTLLPS
>NZ_CP037858.1|WP_004154430.1|1467852_1469022_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MNFHEYQSKQLLAEYGIPVPAGKVAATPDEAVAAANSLGQGPWMVKAQIHAGGRGKAGGVKFCKTTDDVKAAAAKMLGTKMATYQTAGVELPVNLVLVTTAGEIVKELYLSVLVDRGTKTITYIASSEGGVEIEQVAAETPELIHSLNVDFVEGVQGYHGRDFGFKLGLTAKQAGQFASIMVNLYRLFNEKDLALVEINPLAILDDGNLYALDGKFDSDDNAAFRQKALVAMRDKTQEDPTEVIASELDINYVTMDGNIGCMVNGAGLAMATMDVIKLNGGEPANFLDVGGGANKQRVIEAFKLILSSDKVEGIFVNIFGGIVRCDMIAEGIIAAVKEVGVKVPVVVRLEGTNVEEGKQLLRDSGMAIIPADNINDGAKKIVEAVKNAA
>NZ_CP037858.1|WP_005410793.1|1466955_1467831_-|succinate--CoA-ligase-subunit-alpha
MSVLINKNTKVIVQGFTGQQGTFHATQMIEYGTQVVGGVTPGKGGTTHIDLPVFNTVADAVQSTGANASVIYVPPPYAADAILEAAAAGIKVIVCITEGIPVLDMLRVKNVLTRSHPDTVLIGPNCPGVITPGECKIGIMPGHIHQPGKIGIVSRSGTLTYEAVKQTTEVGLGQSTCIGIGGDPINGLNFVDCLKLFNEDPQTEGIIMVGEIGGDAEEAGAEYIKNHVKKPVVGFIAGASAPAGKRMGHAGAIASGGKGTAEGKFAAMEAAGVVTVRSPGDLGAAIAKLVK
>NZ_CP037858.1|WP_142806622.1|1465140_1466775_-|NAD+-synthase
MASIRIAMAQFDFPVGDVAGNTERIIEMIGQARDEYGAELVMFPELAVSGYPPEDLLLRPGFLYECEQAMTRIAAACRGITAVVGWPQAAGAVVYNAASVLRDGLVEQTYRKRELPNYAVFDERRYFDVDPDGGSCVFEVNGVPVGLLICEDLWFAEPLADTVRAGAQLVVVPNASPYERGKHAQRDAVLAARTRESGAAIAYLNVVGGQDALVFDGASVVADGDGTVHPAAAAFVDQWLVVEYDGETRRFMPHVWMDDGDESMDALAWRAVTRGIQDYCRKNGFRKVWLGLSGGIDSALVLAMAVDAMGAENVTAVRLPSRYTAGLSNDLAAEQCQALGVKLEAVSIEPAFKGLMESLAPIFEGTTPDVTEENLQSRSRGVILMALANKFGGLLLTTGNKSEYAVGYATIYGDMCGGYAPLKDLYKTEVFGLSKWRNTVGGAPVIPPAVISRPPSAELRENQLDQDSLPAYDVLDGILYRYIDQEQSRTEIVAAGYDAAVVDRVLHLVRISEWKRHQAAPGPKVSRRAFGRERRYPISNGYKG
>NZ_CP037858.1|WP_099553725.1|1463876_1465067_+|lipase
MSPSVSRARPLLAAFASALLGLSTAAQAAEPGELITAAPYRAAWVPSKASQAYLLSYRTPDHHGRLAQGTGLLYLPAGTAPTGGWPVVSWAHGTQGIADHCAPSHSGPTHAERDGRFLDTFLAQGYAVAAADYQGLGSPGSHAYLHVRTAARNSIDMVKASHQFLGGRLSPRWVSVGYSQGGAAALSAGHQAATYSGPGLQYKGSFTAGTPTAVEMTALVMRPDSRTANPGAVNAYHAYLLDGLLQVAPQIDRVLSAQGRARIALARQHCLTDLAAQLEGAVTGEMFSAPLTSVPGIWALLHDYLGVPRQGFTQPLMLAHGTRDQDVPYLTTLLYAAGLALRGEPVAFRQYPVDHRGTLDAAAADGLAFVRARLGDSQFDEATETATLEQLMGDVP
>NZ_CP037858.1|WP_024956778.1|1462793_1463681_+|outer-membrane-protein-assembly-factor-BamD
MIRRSSMLSAPVRLTALLLVLVIAATGCHRGAKKGDRPDEGTPVEQLYEKSHKLMQGGNWSGAETSFRRLVAQYPYGPYTEQAMIETAYAQYKAGKHDDAVSSIDRFIRTYPTHRNIAYLYYLRGLANSNRSTVFLRRVWSLDASRRDLSTPHQAYSDFNIVVDRYPNSRYAADARQRMLELRDVFAQHELDNALYYMRRGAWVSAAGRANYLLETYPQSAFQYDAVAVLADSYTHLGNKTLADDARRVLQLNQPDHPWLEGKWPKYPWMIRKLNPFAGEKSASTGQRNARLEKK
>NZ_CP037858.1|WP_142806621.1|1461690_1462680_-|23S-rRNA-pseudouridine(1911/1915/1917)-synthase-RluD
MSEQPSESARQAIVPDTAAGRRFDAVVAEMFPEYSRSRLTEWIKAGEVLLDGAQVRPRDPLRGGEVVTLNVVLETQTDAQPEDIPLDVLFEDEHLLVINKPVGLVVHPGAGNHSGTLVNALLFRDPSVAVLPRAGIVHRLDKDTSGVMVVAKTLEAQTALVEQLAARDVHRQYLAIVMGALVAGGTADAPIDRHPRDRLKMAVREDGKEAITHYRLRERFRAHTALECRLETGRTHQIRVHMAHVRHPIIGDPLYGGALKLPKGASDELVAALRGFKRQALHAETLEFTHPITGEPVRNTAPVPEDMLHLMKVLREDSEAFAARERDRW
>NZ_CP037858.1|WP_142806620.1|1460920_1461691_-|peptidoglycan-editing-factor-PgeF
MDAALPLLWADWPAPAGVHALITRRHGAGISPAPFAQFNLGNRHAADGDAPANVEHNRQLLQQGLALPSAPHWLRQVHSSTVLRFNAPPVPGAAEPVADAAVTSVPGVVLAILTADCLPVVFAAADGSEVGAAHAGWRGLADGMLEATVAAMQTTPGQLRAWLGPAAGPADYEIGEEVYHAFVGHDPAAGVAFVATRAGHWKVDLFALARQRLQAAGMDPAQVYGGTVSTMADPDLYSHRRDRRTGRMATLAWIAP
>NZ_CP037858.1|WP_099553720.1|1460393_1460900_-|DUF4166-domain-containing-protein
MLGPAFATLAAPVQALHAAPLPCRYAGQARIVRGRHWLVPLLAAVARLPKSGDALPTEVAFSAHGQGEQWARRFGRWPMASRLWEHEGHLHEQLGAVRFAFDLQARDGGIDWSVRRVWAFGLLPLPTRWFGGVRCREAWQGQRYTFLVDVTLPWAGALIRYEGWLEPQ
>NZ_CP037858.1|WP_142806625.1|1474535_1474943_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MNTQKGFTLIELMIVVAIIAILAAIATVAFQPYIIRTQLTAALADISPGKMLVETVVYENRSASLVTPEFIGGAQNAHCSNVEAELSDSGVGHISCTLKGHSALEGKDLILRRSAEGIWSCDGSAFEARYRPTGC
>NZ_CP037858.1|WP_142806626.1|1475095_1475533_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKNQKGFTLIELMIVVAIIAILAAIALPAYQDYTSKSKVTAALADLASHKTQFEMEISSGRTPTAATAGFQAEETGSCSEVAVAKTGMTCTIRDPGRIGTSSTIALKYDEATVDATSGAITKAGGFSCVTVSVDKKFRPAGCTGT
>NZ_CP037858.1|WP_142808074.1|1475885_1477145_+|type-II-secretion-system-F-family-protein
MSVSRSAIKKEPVARATMELQPFVWEGTDKRGVKMKGEQLAKNANLLRAELRRQGINPGQVKPKSKPLFGAAGSPIKPKDIAFFSRQMATMMKSGVPIVSSLDIIASGHKNPRMKKLVDTIRTDIEGGSSMHEAISKHPVQFDELYRNLVRAGEGAGVLETVLDTVATYKENIEALKGKIKKALFYPIMVVVVAMLVSGIMLVFVVPQFKDVFKSFGAELPAFTQMVVNLSRFMVSWWWLMLLVAIGTAVALVMSYKRSPKMQHAMDRFVLKVPVIGQIMHNSAIARFSRTTAVTFKAGVPLVEALGIVAGATGNTVYEEAVLRMRDDVSVGYPVNMSMKQTNLFPHMVIQMTGIGEEAGALDAMLFKVAEYYEQEVNNSVDALSSLLEPMIMVFIGTIVGGMVIAMYLPIFKLGAVVG
>NZ_CP037858.1|WP_049429911.1|1477152_1478016_+|prepilin-peptidase
MAFLDQHPGLGYPAAAAFGLLLGSFLNVVILRLPKRLEWQWKRDAREVLEEPDFYEPPPPGIVVEPSHCPHCKHKLSWYENIPLFSWIIQGGKCRHCKAPISLQYPLVEAMTSLLVVACVWQFGFGWQGFGAIVLTCFLIALSGIDLRTQLLPDQLTLPLMWLGLIGSIDNLYMPAKPALVGAAVGYLSLWTVWWLFKQLTGKEGMGHGDFKLLAALGAWCGLKGILPIILLSSVLGAIIGSIWLYSRGRDRATPIPFGPYLAIAGWLYFMWGAPLVEQYMVMSGLR
>NZ_CP037858.1|WP_142806627.1|1478027_1478639_+|dephospho-CoA-kinase
MSRYVVGLTGGIAAGKSEVTRRFEALGIVVADADLAARAVVAAGSPALARIAERFGADMLLADGNLDRGRLRAHVFADPAERTALEAITHPAIRLLMQQQCEQAESPYAIAAIPLLTEVGGRKAYPWLDRVLLVDAPEAVQHARLMQRDGIDAALADQMIAAQASRAQRLALADDVVVNDGQPEDLQVQVEQLHARYLGLAGG
>NZ_CP037858.1|WP_099553741.1|1478736_1480104_-|HAMP-domain-containing-histidine-kinase
MASDTASPPRKPDSVAAKGERRRTPYRRRLRSRIIVSFVLLGFCLTTLFAFATNWARLRVENQLVEELMNRNIDEYARRYYEHPGHNPDAPVLQIRAYAYSKDKFDRVREERAQWAGFSDGIHSVSGDEHGEPYSYKLAVRKTPDAWFFLAYDMTDSVRGGKQLNRALVLSVLVFSVLSLVLGWWSASKVMKPVSDLAARLRAYRGGTSDPEPLAPRFPDDEVGQLAQALDDYSSRLTEVVQRDREFNADVSHELRTPLAVIRGATELLLTRPGLDEKVLQRLQRIQRAEQQCSDLIGALLLLSRNERGQGTSNVARVAEQLLDAHRAQLGGKPLELLLEGERNLVIDAPEAALSVALGNLIGNAVKYSQDGEVRVFVGTNSVSVTDSGPGLSEEDAAKLFQRGYRGTHAGHSQGGGIGLSIVSRLCDLYGWQVSVRPGGERGVIATLTFSPKPL
>NZ_CP037858.1|WP_005410804.1|1480066_1480744_-|response-regulator-transcription-factor
MRILVIEDNSDIAANLGDYLEDRGHTVDFAADGVTGLHLAVVHEFDAIVLDLNLPGMDGIEVCRKLRNEARKQTPVLMLTARDSLDNKLAGFDSGADDYLIKPFALQEVEVRLNALSRRGKGVQTRVLETGDLEYNLDTLEVRRQGKLLQLNPTALKILQALMEAAPAVVTRQELETRVWGEELPDSDSLRVHIHGLRAVVDKPFEVPLIQTRHGIGYRIATPEA
>NZ_CP037858.1|WP_099553743.1|1480752_1481223_-|hypothetical-protein
MKQALMSAVLLSGLALVSTASASRGKEVFVPGQPLQQQIARIEVELKDGETYSELKQDERTRVNDALARMRAAVEQYPARDSMPEPVQTQVFNDQQVVNTVLTQAREDSRLICQREKPIGSNRTTTQCMTVAERARQKERAQQDMRQVMRAGSTVN
>NZ_CP037858.1|WP_142806628.1|1481312_1481789_-|hypothetical-protein
MYRITMIALLLGLAGSAAAKPETSVVQMDRQSPVAEQVRQVEKALDDGDYSEISADDRSEVRQALARITARMGAHQSLQELPPQVQGEVFNDQERINTLLTRAHEDSRQICQHTRSTGSNMPKSRCLTVAERRRIEEKGKALLNDQRTFNNFNPASSR
>NZ_CP037858.1|WP_005410807.1|1482035_1482914_-|30S-ribosomal-protein-S6--L-glutamate-ligase
MKLAILSRNSSLYSTRRLVEAARARGHTVRILDPLRCYMRIAADGFSMHYKGRPMTGVDMVIPRIGASITRYGTAVLRQFELMGARTPNPSDAILRSRDKLRAHQLLAAKGIDMPVTVFGDNPDDTVDLLSMLGPPPHVVKLNEGTQGRGVILTEKASASRGIVEALRGLYANFLMQEFIGEAKGADLRCFVVGDQVVASMQRQAPEGDFRSNLHAGGTAVAAKASRAEQQVAVRSAKALGLSVCGVDLIRSARGPLVLEVNSTPGLEGIEAACGVDVATRIIEHVEKLKKP

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Crispr_ID: NZ_CP037858_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_4

2443675-2443761

Orphan

Consensus_repeat	Method
GGTGCCACGCTTGCTTGGCACGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP037858_4

>merge|NZ_CP037858|4|2443675-2443761|CRISPRCasFinder
GGTGCCACGCTTGCTTGGCACGCTGCCCTGCCGGCCAGCGGCCGGCACTACCGCATCCCCGGTGGGTGCCAAGCTTGCTTGGCACGC

>NZ_CP037858|4|4|2443675-2443761|CRISPRCasFinder
GGTGCCACGCTTGCTTGGCACGC	TGCCCTGCCGGCCAGCGGCCGGCACTACCGCATCCCCGGTG
GGTGCCAAGCTTGCTTGGCACGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_142807075.1\|2440918_2442862_+\|acetate--CoA-ligase	unknown	unknown	gnl\|CDD\|234677
NZ_CP037858.1\|WP_142807079.1\|2453658_2454906_+\|heat-shock-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_006403404.1\|2462940_2463852_-\|glycine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|236473
NZ_CP037858.1\|WP_099554341.1\|2458774_2460571_-\|outer-membrane-protein-assembly-factor	unknown	unknown	gnl\|CDD\|223801
NZ_CP037858.1\|WP_049436024.1\|2433323_2433962_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NZ_CP037858.1\|WP_099551802.1\|2437473_2439135_-\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP037858.1\|WP_142807071.1\|2434001_2434601_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl\|CDD\|225002
NZ_CP037858.1\|WP_099554348.1\|2450519_2452208_+\|molecular-chaperone-HscC	unknown	unknown	gnl\|CDD\|212677
NZ_CP037858.1\|WP_142807080.1\|2454917_2458778_-\|translocation/assembly-module-TamB	unknown	unknown	gnl\|CDD\|225463
NZ_CP037858.1\|WP_142807072.1\|2435009_2435777_-\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197320
NZ_CP037858.1\|WP_005411656.1\|2434685_2434937_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_CP037858.1\|WP_099554352.1\|2444663_2448110_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|271357
NZ_CP037858.1\|WP_142807078.1\|2452204_2453662_+\|J-domain-containing-protein	unknown	unknown	gnl\|CDD\|365959
NZ_CP037858.1\|WP_142807074.1\|2439245_2440673_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379826
NZ_CP037858.1\|WP_142807081.1\|2460777_2462853_-\|glycine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234925
NZ_CP037858.1\|WP_006477308.1\|2442941_2443607_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP037858.1\|WP_142807076.1\|2444041_2444617_+\|manganese-efflux-pump-MntP-family-protein	unknown	unknown	gnl\|CDD\|224882
NZ_CP037858.1\|WP_142807073.1\|2435895_2437305_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143451
NZ_CP037858.1\|WP_142807077.1\|2448245_2450393_-\|S46-family-peptidase	unknown	unknown	gnl\|CDD\|371067
NZ_CP037858.1\|WP_032128472.1\|2432413_2433211_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_142807075.1\|2440918_2442862_+\|acetate--CoA-ligase	gnl\|CDD\|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_CP037858.1\|WP_006403404.1\|2462940_2463852_-\|glycine--tRNA-ligase-subunit-alpha	gnl\|CDD\|236473	PRK09348, glyQ, glycyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP037858.1\|WP_099554341.1\|2458774_2460571_-\|outer-membrane-protein-assembly-factor	gnl\|CDD\|223801	COG0729, COG0729, Outer membrane protein [Cell envelope biogenesis, outer membrane].	1.94956e-148
NZ_CP037858.1\|WP_049436024.1\|2433323_2433962_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	2.11487e-83
NZ_CP037858.1\|WP_099551802.1\|2437473_2439135_-\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.62705e-120
NZ_CP037858.1\|WP_142807071.1\|2434001_2434601_-\|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl\|CDD\|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	2.39926e-31
NZ_CP037858.1\|WP_099554348.1\|2450519_2452208_+\|molecular-chaperone-HscC	gnl\|CDD\|212677	cd10235, HscC_like_NBD, Nucleotide-binding domain of Escherichia coli HscC and similar proteins. This subfamily includes Escherichia coli HscC (also called heat shock cognate protein C, Hsc62, or YbeW) and the the putative DnaK-like protein Escherichia coli ECs0689. It belongs to the heat shock protein 70 (Hsp70) family of chaperones that assist in protein folding and assembly and can direct incompetent "client" proteins towards degradation. Typically, Hsp70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. Hsp70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs). Two genes in the vicinity of the HscC gene code for potential cochaperones: J-domain containing proteins, DjlB/YbeS and DjlC/YbeV. HscC and its co-chaperone partners may play a role in the SOS DNA damage response. HscC does not appear to require a NEF.	0
NZ_CP037858.1\|WP_142807080.1\|2454917_2458778_-\|translocation/assembly-module-TamB	gnl\|CDD\|225463	COG2911, COG2911, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP037858.1\|WP_142807072.1\|2435009_2435777_-\|exodeoxyribonuclease-III	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	4.67069e-138
NZ_CP037858.1\|WP_005411656.1\|2434685_2434937_+\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	3.33495e-10
NZ_CP037858.1\|WP_099554352.1\|2444663_2448110_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	3.19195e-66
NZ_CP037858.1\|WP_142807078.1\|2452204_2453662_+\|J-domain-containing-protein	gnl\|CDD\|365959	pfam00226, DnaJ, DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.	5.5259e-05
NZ_CP037858.1\|WP_142807074.1\|2439245_2440673_-\|hypothetical-protein	gnl\|CDD\|379826	pfam16331, TolA_bind_tri, TolA binding protein trimerisation. This is the N-terminal domain of the YbgF protein. YbgF binds to TolA. This domain mediates trimerisation.	0.000106893
NZ_CP037858.1\|WP_142807081.1\|2460777_2462853_-\|glycine--tRNA-ligase-subunit-beta	gnl\|CDD\|234925	PRK01233, glyS, glycyl-tRNA synthetase subunit beta; Validated.	0
NZ_CP037858.1\|WP_006477308.1\|2442941_2443607_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.82215e-58
NZ_CP037858.1\|WP_142807076.1\|2444041_2444617_+\|manganese-efflux-pump-MntP-family-protein	gnl\|CDD\|224882	COG1971, COG1971, Predicted membrane protein [Function unknown].	4.13501e-59
NZ_CP037858.1\|WP_142807073.1\|2435895_2437305_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143451	cd07133, ALDH_CALDH_CalB, Coniferyl aldehyde dehydrogenase-like. Coniferyl aldehyde dehydrogenase (CALDH, EC=1.2.1.68) of Pseudomonas sp. strain HR199 (CalB) which catalyzes the NAD+-dependent oxidation of coniferyl aldehyde to ferulic acid, and similar sequences, are present in this CD.	0
NZ_CP037858.1\|WP_142807077.1\|2448245_2450393_-\|S46-family-peptidase	gnl\|CDD\|371067	pfam10459, Peptidase_S46, Peptidase S46. Dipeptidyl-peptidase 7 (DPP-7) is the best characterized member of this family. It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.	0
NZ_CP037858.1\|WP_032128472.1\|2432413_2433211_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	4.91681e-89

>NZ_CP037858.1|WP_006477308.1|2442941_2443607_+|response-regulator-transcription-factor
MTTLLIADDHPLFREALRGAVQRVIPGVQLFEADSVEALYALADQHNDADLVLMDLNMPGAQGFNALVHMRSLHPHLPVVVVSAREEATVMRRALDHGALGFIPKSADSDTIGHALGTILDGETWAPPEAHNVPPTGSEEREVGQRLRELTPQQFRVLQMLGAGRLNKQIAYDLNVSEATIKAHVTAILRKLGVTNRTQAVLMAGKLAIDDDAIVLPPEED
>NZ_CP037858.1|WP_142807075.1|2440918_2442862_+|acetate--CoA-ligase
MADIYPVDPQFAAKARIDKTSYEQQYQASLTDPDGFWGKAAERLEWMRKPTKIRNVSYDLSDFHIKWFEDGELNASVNCLDRQLEKRGDKTALLFEPDSPDAPAQHVTYRELYERTCRLGNALRNLGVKKGDRVTIYLPMIVDAAVAMLACARIGAIHSVVFGGFAPNSIADRVSDCQSKLIITADEGLRGGRKIPLKANVDAALKLPGTNTVETVLVVRHTGGAVDMQAPRDRWFHDVVDSQPASCEPERMNAEDPLFILYTSGSTGKPKGVLHTTGGYLLYAAYTHEAVFDLREDDIYWCTADVGWVTGHSYIVYGPLANGATSLMFEGVPNYPDTSRFWNVIDKHKVSIFYTAPTAIRALMREGEEPVKKTSRASLRLLGSVGEPINPEAWRWYYEVVGDSRCPIVDTWWQTETGGILISPLAGAMDLKPGSATLPFFGVQPALVNADGEIQDGPTEGNLIIRDSWPGQMRTVYGDHQRFIDTYFRTYPGSYFTGDGCRRDEDGYYWITGRVDDVINVSGHRIGTAEVESALVSHPKVAEAAVVGFPHDVKGQGIYAYVTLVAEEAPSDELQKELVAWVRKEIGPIATPDHLQWAPGLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSVVASLVDERKVR
>NZ_CP037858.1|WP_142807074.1|2439245_2440673_-|hypothetical-protein
MSHRTLKAVRTPLAACLLVALVAPGMAFAETAKEKALEARVAELERQVQLLLSSQQQQQTQISQTQQAVTEVRTVQAEQKSVASVPAGKQPIQVTTITPGAAPGTTVKIGGFIKADFLATQTSDGQLADDATGRSLYLPGQTPVEGAGGSGKRSGTDFNAHAKFSRFNLGIDNVSESGNKAGAFFEMDFFGNSLGNQTATNTYGVTLRHAYMYWNNWMAGQTWSNFMDAAALPEAVDFVGPTDGVIFVRQAQVRYTQGGFSVALENPETTTLTGTRNPVTGAWTNASANSDRGSLPDLTMRYGWKGDWGTFGVGGIVRQLKVDNQATGAKADKVAGGLTLGGKWVMGDSDSLHYQLTGGEGIARYIGLGITADSAYDVARDELNPTGVLAGYVGWRHAFSSKLRTNLIYARSDYDNDSILGPLVTKSVQSIRGNIFYSPLPKVDIGAELMYGRREVENGNKGDITRLQFTTKYSF
>NZ_CP037858.1|WP_099551802.1|2437473_2439135_-|MHS-family-MFS-transporter
MSSTPSTAHKAGTLTQGHKKVIFASSLGTVFEWYDFFLYGSLAAIIAKQFFSGVNETTGMIFALLAFAAGFFVRPFGAAFFGSLGDRIGRKYTFLVTILIMGISTFLVGVLPNYASIGFAAPVILIILRLAQGLAMGGEYGGAATYVAEHAPDDKRGLYTSFIQCTATLGLFMSLLIILACRYFLGNEAFEAWGWRIPFLVSILLLGISVWIRLQLSESPLFQQMKSEGKGSKTPFRDSLKGGNLKLMLLVLLGAAAGQAVVWYGGQFYALFFLSSMLKVDATTSYLLIAAALALGVPFFIFFGWLSDRIGRKKIILAGCLLAAVTYIPIFKGLTHFANPAIEEARSSSPALVVADPNTCSFQFDPVGLRKFTSSCDVATAALTKAGVPYDVQPAAAGSLAMVNVGSASVTSYEAAGLTKEDGKAKADAFGAELKTALTTAGYPAKADGARINIAGTIFMLWLLVLYVTMVYGPIAAYLVELFPTRIRYTSMSLPYHIGNGWFGGFLPAISFALVAGTGNLYYGLWYPIIIALMSVVIGGLFLRETKDVDITK
>NZ_CP037858.1|WP_142807073.1|2435895_2437305_-|aldehyde-dehydrogenase-family-protein
MTITTPADLPAILHTLRSAWQSQRPTLDQREADLRRLREALKPRLDEMAQAIAEDFGHRAHVESKLADGMSVLSAIDHLRRHLRRWSKPQRVGAGWRLWPARAQLRPTPLGVVGVISPWNYPVTLALVPLATAIAAGNHVLLKPSEHTPRTSAFLADLLASVFPPDRVAVVQGGADVAAAVSSLPLDHLLFTGSTAVGRKVMAAAAEHLVPVTLELGGKSPAIVCRDFPLDTAAARLATGKWFNAGQTCIAPDYVLIDTARQREFVQALQQQVRERYGDFSEAGDYTRIINEGQYRRLQGYLAQARERGVPVIPLAQVNEARADRERLLVPTVVLDPPDDLELMREEIFGPILPVRAYPDLEAALADVLSRDRPLALYPFSHDTATVERILGQVVAGGVTVNDTLLHFAADGLPFGGVGASGMGAYHGRAGFDAMSKRLPVLWQSRWAASDRLRPPYSKIAGLLKLLLR
>NZ_CP037858.1|WP_142807072.1|2435009_2435777_-|exodeoxyribonuclease-III
MKIASWNVNSLNVRLPHLEQWLKEFGPDIVGIQETKLEDHKFPDSALIAAGYRSVFAGQKTYNGVALLSREPAQDVQIGIPGFEDEQKRVIAGTFGDLRVINLYVVNGQDIGTDKYDYKLRWLEAVHAWIAEELQRHPKLIVMGDFNIAPDARDVHDPEVWNENHILTSTAERGALNKLLQLGLHDGFRLHNDEAGVFSWWDYRAAGFRRNLGLRIDLTLVSEALKGSAVASGIDREPRTWERPSDHAPAWVQIA
>NZ_CP037858.1|WP_005411656.1|2434685_2434937_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGIIIWLIVGGIVGWLASIIMKRDAQQGIILNIVVGIVGALISGWLFGGGINEAITIRTFLFSLIGAVILLAIVNLFTRKSIR
>NZ_CP037858.1|WP_142807071.1|2434001_2434601_-|4'-phosphopantetheinyl-transferase-superfamily-protein
MSLPATLDGPWRFGPVTVWRRPHVPGHRGEPQARQVLAQALGADPETLPLVRDDKGRPELSGALAHYGTGWSHSGEVLLVALGEGVRLGVDLELLRPRPRLLEIVRRFFHPEEVIWLESLDEAGREHWFFRVWCVKEAILKAHGQGISFGLHRLQLAPGADGALHLRWCDPELGEAARWHLHEWQATGQFRAALAWYPH
>NZ_CP037858.1|WP_049436024.1|2433323_2433962_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MSEHPLPASVAATLEQGLASMGLDAALAPPLLRYLALLHRWNGTYNLTAIRDPQEMVTRHLLDSLAMQPFVADGSLADLGTGPGLPGIPLAIACPGLQVTLVESNGKKARFMREAVRQLGLDNARVAESRAEALDEAGRYDQLTARAMDTLAGIVRVGGHLLRPGGVLLAMKGVYPHEEIADLPAGWQVREVTPLSVPGLAGERHLVTVTGP
>NZ_CP037858.1|WP_032128472.1|2432413_2433211_-|ParA-family-protein
MARIIAIANQKGGVGKTTTAVNLAASLANAPKRVLLVDLDSQGNATMGSGVDKRELVSSTYDLLLGESSAADVRVQTAEGYDLLPGNIDLTAAEIQLMAQSEREQRLKRALAPIRDEYDYILIDCPPALSLLTLNALAAADSVIVPMQCEYYALEGLSALVETIEALRANLNPALEIEGVLRTMFDVRNNLANAVSAELTEHFGDRVFRTIVPRNVRLAEAPSHGQSIVGYDRASRGGVAYLGLAGEIIRRNNERNKAAKAVETV
>NZ_CP037858.1|WP_142807076.1|2444041_2444617_+|manganese-efflux-pump-MntP-family-protein
MSPISILLIGFAMSTDAFAAAIGKGAAMRKPVFRDALRAGIIFGVIEAITPIIGWLLGRAALQYVEAFDHWIAFGLLGALGIHMIYNGLRPDSDEADEDPSQHHGFWKLALTGFATSIDAMAVGIGLAFMDVHIGVMAAVIGLCTLTMVTAGIMLGRVLGSMVGKRAEIIGGVILVIIGATILYEHLHGVG
>NZ_CP037858.1|WP_099554352.1|2444663_2448110_-|hybrid-sensor-histidine-kinase/response-regulator
MVSSWILLLVSVAYAALLFGVAWWGDRRPMYPDRPWLRPVVYSLALAVYCSSWTFYGAVGTAVRNGVGYLPIYIGPLLLLLFGWRIIERLALIARSQNVVSIADFISSRFGRSRRLAALVAIIALIGIIPYLALQYKAVAMSLQVLTGNTGPTGFFTDPALYVALLMALFATLFGTRQVDATEHHHGMMLAIAFESVIKLLAMVAVGVFAYLWLSNRTDAVVESVHTLFTGLPPVGFISQTLLSFLAIICLPRQFHVAVVECGDVRDVRRARWMFGGYLVVISGMVLPIATAGVTLFGTGGSVADDSMVLALPLAEGRNALALIAYVGGFSAATGMVIVSSIALATMVSNDLVMPVLLRRSGDHQEAADVASRVLWIRRLAILLLALMAYSYYRTSSNDSTLASYGLMAFAAVAQFAPGLIGGLYWRGASRRGVETGMLLGFATWLYTLLLPAMTMAGWVDAAWVQHGPFGIEWLRPQQLFGMTGWDPLTHGTFWSLLVNAATMMLVSARWRPGVDERLRAAPFLDPYAERPSVAGGWPGHVHVGDLLALASRVVGERHARRSFFEQAQSLGRELQSSAPADRPWVQFTERLLAASIGAASARLLLTSLLRGSGMDLGEVVAVLDEAGQELRFNREILSTTLENISAGVSVVDPDMRLTAWNRRYQDMFGYPDGMLYVGRPVADLIRYNAERGELGEGDIEVQINRRIGYMRAGSPHVFERTRSDGKVIEMRGQALPGGGYVTSYNDITDYKHAEKALLEANETLEQRVAERSHEAEVAQQSKTRFLAAISHDVLQPLNAARLFASALRDSDHVSDEQKHLAERVDASLRAAEELLDGLLDVSRLDAGGLHPVIGEFDVSALMRELAAQYTPVAAGRGLRLDLFARPAWVRSDRRLLRRVLQNFLANALRYTRQGRIVLAVRHRGDEVELQVWDTGPGIPEHHMRQIFDEFHRYQQPFDWGEQGLGLGLSICQRISRLLDHRLNARSRVGSGSMFSIILPRVAPLPGYTELATPVQAVTAPVRSDSLAGLRVLCVDNDEEILDGMRALLGRWQVQVITAATVDQALEKIAERPQVMLVDYHLHDRMDGLDALVALREAAGYVLPGALLTADGRDELKRMARERGYRVLTKPIKPASLRAFLGALRDAQ
>NZ_CP037858.1|WP_142807077.1|2448245_2450393_-|S46-family-peptidase
MSPRKALPTALALGLTLAAGAHADEGMWMPTQLPELAKPLQAAGFKGNPADLANVTAPPLSAVVRAGGGTGSFVSADGLLLTNHHVAMGVIQYNSSPEHDLINGGFIAKDRADERPANPDFRVLVTVGFDKVTDQVLAQAGGKTGRAYFDAVDAASKQIVAECEKDGSVRCSVANMYYGTDFYRIAQLELSDVRLVYAPPRAIGNYGDEIDNFMWPRHTGDFTLLRAYVGKDGKPAAYSKDNVPYQAPAHLQMSVEGPKEGDYAMLAGYPGITYRHRTAAEFAGQIDAVLPRRVSVFQQMIDTIEAASAKDAQARTRYASQLQSLKNNRKRAAGELEGLLRSDAKAQRAADETAMLAATDRKYQADIKALLANLSQGAAVGERDLLLDQMAAQSQLLRSALLLERLRIESAKPDAQRESGFQQRDQAMIEGVLKQVQRRYAPEVEKALLTTLLTRYQKLPDAQRVAEFDAAFGRTPEQLAKALDTLYAATQLGDEAQRLSRFAAAREGKALAADPLIAVAGPLVAAQLRIENESKTREGEQLRLRPAYMQALFAWRAKQGRAVYPDANRTLRISYGKVEALHPRDGVTYSPVTTVAGIVEKNTNAYPFDAPKPLLAAIAKGDFGSTADPALKTQTVNFLTNLDTTGGNSGSPVLNAKGELIGLNFDSNWESVSASWWFDPRYKRAVHVDMRYLRWLLAKVYPAPELLKEMGVPAQ
>NZ_CP037858.1|WP_099554348.1|2450519_2452208_+|molecular-chaperone-HscC
MIVGIDLGTTHSLIGMHTAAGPQLFPNAHGELLTPSVVSLVDGAVLVGQPARDRLVSHPQQTVAHFKRWMGSDRETRLGERSFRPEELSAMVLRSLLADAEAALGRKVEEAVISVPAYFSDAQRKATRAAGELAGIRVERLINEPTAAALAYGLQERDGEGRVLVLDLGGGTFDVSILELFDGVVEVHASAGDNFLGGEDFLQVLVQAFHADQRTSASDLSAAEQAQLLRRLELFKRELSQNSTASLQLPLAGSERHWQLDEARYTQLCEPLLLRMRTPIERAIRDARLKPEALDDIILVGGAVRMPMVSKLATRMFGRLPLRHVHPDQAIALGAAVAAGLKARDESLREVVLTDVCPYTLGTQVSRQDVSGGERSGYFHPIIQRNSVVPVSREDRFYPLHERQSAIRIDVFQGESPTVDRNIKLGELTVPLTHSVPMQERSVTARFTYDVNGLLQVEVTEDTTGKRHELILEQNPGLLSPEEIQQRLRALEALKIHPRDAQPNLAVIARTERLYEERIHHRELLQSWLSSFRHVLESQDAVAVERHRHQLDEALDTLERDA
>NZ_CP037858.1|WP_142807078.1|2452204_2453662_+|J-domain-containing-protein
MSWALHVLELDETADERAIKRAYAKRLRVTRPDEDPIAFQHLHEAYQAALDWARQDPLADTADEAEPAEHAADIVPWPYDVDVAWAPPETRSYSPPLPPRGTPVLLRTAPVVELEGVVDVPGHAQLILRQAYLLPVDDFGPWLEATPVLWSLRYKPLAGDALLDELARSHNGISAANMGLLARCFGWDDVHDGVDPDRLASIQSRGHRRWAAETGNAAELSALLEREGSLRLGKITVSRCLSYLSQPWNLRRSLWQAQLPEHINEVNALLDAIESGGREQVPEAWHPQQILFWRSLADVSRPNRWRWQVNALRGVLLGVCSLLFFGGIAGVSLVQGKAGEAAMFVQLGALLGLLLAVMGVLWVPVRWALRQLTLDLTHQRAGLLLALPAPLMAIGSLVLVHGLGHRMEGTLLIFMALPLATARLWRRVGARMRFGIRHAVFMVLAMLIAEAGIVLTLLQWGAEFLHRARRHVPIDRLPPASGNTA
>NZ_CP037858.1|WP_142807079.1|2453658_2454906_+|heat-shock-protein
MKQALDALGLDASADEQAIKRVYAQRLRGARPDEDPVAFQALHEAYQEALQWARNRAQWQEESSAEALSIPPADNSPPVSSPPYDNHSPMDHMPVLHHPCTLDTDMPDDVVEPPLNLPRFARLLINTAADADPASFERWLAHRPELWSLADRPRIGDVVLQQLLHQGGPLCESNFDLLSRYFCWDEIRGDIDPYRVRARRSQLHRHWLLQPRNHAALTEALDRPQDRVSAQEAHARMERLTRPWHWLESTLSACVPGRAGTMRRTMQHLGVHTVRDTLAPLDADQIAFWMAISQPRHFSLLKMQVAIVRCLLGAMIVLAVLAVLALLGDAARPLALSTSGMKRVAIHASVVIVAGVVMLATFVGWTPSRTASAPAPVEPSSPSDALGMLTHGPRPRRPAPSFAVVSQMDPGTEGG
>NZ_CP037858.1|WP_142807080.1|2454917_2458778_-|translocation/assembly-module-TamB
MSTPAPAPNPTTPPRVRFYRRRRFWAWSGVGVLGLVLLALLAVYWLLQTVAGRDVLLAQVVARLPVGASFTWDKVEGPVAGPLTLYNVDFRYDDIHFHAERAHLEPDLRPLLGRKLLLDKLELTNATLNLAKSDEPFKLPSWPDSLPQIEMPLAIQADAIAIDGFRISQANEPVIDISRVRGGIEIANGEFQAHKLVVDSDMGNFTAQGRYIPAKDYDTDVTVTAVLPAPRGRTAATVGLVARGDLSHMEVAVAGRAPKPLHAMLVFDGRTDPSWSASIRSDELDLALLSPALASSAIAPLALDFTAAGKGGNANLRGKVKQGDQELELAPSVVSLKDQVLNVSPLLVKGLGGEARLEGTADFSQEDQQKLNFSVVAHDLTYVPAADPNTAGSAPVPVTLKEARFGLAGTLKAWAAIGRAEVERDAQKAQLHFDVRGNDQAASIHQLQAQTPGGQLQVEGQVAWAPQLDWDAKATLKDFDPGYFVPGWNGRLSGNLASKGRQLPPPANAPPGTAGTLEATVDLPSLKGVLRQRNLDAQGKFALQGAQGQGDLKLSLGSSRVTASGKVGDRLDIDARFEPLQLSDLLPGADGGLRGQVQVKGPRDAPDITADLVGNNLNWDGYGAESVSIKGHLPWRGDSGTLAIQGQQVNAGMLLERLNVDAQGSVSNLRLAAQTRNEMGAIELQGSVRQQGAQWRGELAALRIAPVKGDAWSLRAPAAFAINGSNYTLGEACLAAASSGTLCAQANWPREGLVVRSDALPLALVQPWLPPQSGRRIYLRGDVSLDAQIRPRGNAWEGHVEVRSKEGGVRLGENRNTVGDTTRGELVRYDQFSLKLDMTPASIKGYLGMGFQGNGFVDARMQTGWEASAPLNGELYLNMSRLYWLELFSPDIVRPTGLIEGHVSLRGTRGQPSLGGDAQLSNFKGEFPALGLTFDQGKGSFVAQPDGSAKITAQANSGQGTLYVDGGLSWFGDAQPLQLKIHGDNVLLSNTSELRIVANPNLDFTLAKAAMELRGTVHVPEADIDLERLDRGTSVSEDVVVLDPADPEESRTSPLDMELVVSLGDKVKMTGFGLKGALTGKMQVWAKPGREMTANGGLEVSGRYKAYGQDLTITRGNLTWNYNAVSDPRINIRAERRIGDVTAGIDVTGRAQQPRADVWSDPAMSQSEALAYLVLGRSLTGASSDQTQQVNAASAALSAGSGLLASQLGAKLGLDDAGVSQSRALGGSVIGVGKYISPKLYVGYGVSLVGAGSVITLKYLLRRGFDVEVESSTVENRGSINWRREK
>NZ_CP037858.1|WP_099554341.1|2458774_2460571_-|outer-membrane-protein-assembly-factor
MLCRMQPKKYALPLMVLSLAATSVAHARGTIDKVDIKGLDKGDDAAIIENIQESLSLYDTIGKEQGESRLEYLLSQAERQTRQALEPFGYYNPVIKVEAPREDEHVRVLIHVDKGTPVTVRREHIDITGPAMYDQYLQDDLAAFKPRKGQRFEHTQYEASKITVTRRLAERGYFDADYTQRQVQITRADNAADIDLTWDSGRRYNMGPVRFEQDYFVDKLFDPLVYWEQGSYFHEGKLDRLRESLTKLDYFSVIDIQPRPDQADANGEVPVDVKLTRAKRTIYTAGLSYGSESGPGVRGGIERRWLNNRGHKMNTQLDYAQKRKSLVTSYRIPAFNWLDGWYTFAASAYDEQTDYIDLRNFKLIASRSGEINEHWTAIASINALRERWRYASGTEFTDAVYNTSTLVYPQLVADYVNVDDELFPRKGISGTATMRAGVEGAGSDTSFVQANAVLRWYIPVGESNRLILRGEGGTTWTSDLVAMPPSLRYFAGGDRSIRGYAYREVGPRTPAPDKYALGAKNLVIGSAEYEHYFNGGPWGAAVFVDTGSAFDNTIDLHTGVGFGVRWKSPVGPVRVDIAHGLNNPDSQFQLYLNIGADL
>NZ_CP037858.1|WP_142807081.1|2460777_2462853_-|glycine--tRNA-ligase-subunit-beta
MSQLSPLLIELGTEELPVKALPGLAQAFFDGVVEGLRKRGVALELGDARPLSTPRRLAVLLPGVGLEQPEQHSEVLGPYLNIALDAEGQPTKALQGFAAKAGIDWTALEKTTDNKGERFVHRAVTPGASTASLLPEILREAIAAMPIPKPMRWGDHAWGFARPAHWLVLLHGANVVEAELFGLQAGRVSRGHRFHHDQAVSLAQPQDYVEALRAAFVLVDPSERRARIVAEVEAAAAKVGGSARITEDNLEQVVNLVEWPSAVLCSFERAFLAVPQEALIETMEINQKFFPVLDDSGKLTEQFIGIANIESKDVAEVAKGYERVIRPRFADAKFFFDEDLKQGLVSMGEGLKTVTYQAKLGSVADKVARVAALAEVIAPQVGADAAQAKRAAELAKNDLQSRMVNEFPELQGIAGRHYAVTGGESQEVALAIDEAYQPRFGGDDIALSPLGKVLAIAERVDTLAGGFAAGLKPTGNKDPFALRRNALGLARTIIESGFELDLRALLASANAGLAARNVQADVGELYDFILDRLKGYYADKGVPATHFNAVAELKPASLYDFDRRLDAIGTFAALPEAEALAAANKRIRNILRKAEGDIPAQIDPALLQEDAERALAEAVTAAIDDTGASLHQKDYVAVLARLARLRPQVDAFFDGVMVNAEDPALRGNRLALLTMLGERLGKVAAIEHLSS
>NZ_CP037858.1|WP_006403404.1|2462940_2463852_-|glycine--tRNA-ligase-subunit-alpha
MSATPTVPITFQGLIQTLNQFWAQQGCVLIQPLDLEVGAGTFHPATFLRAIGPESWNAAYVQPSRRPTDGRYGENPNRLQRYYQYQVAMKPAPDNIQQLYLDSLKALGIDPLVHDLRFVEDNWESPTLGAWGLGWEVWLNGMEVTQFTYFQQAGGLECRPVLGEITYGLERLCMYLQNCDNVYDLVWTYGPDGQPVTYGDVYHQNEVEQSTYNFEYADVEEMFHRFDACEREAQKLVEVNLPLPAYEQVMKASHTFNLLDARRAISVTERQRYILRVRALAQAVAKAYYEQREKLGFPGAKKA

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Crispr_ID: NZ_CP037858_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_5

2623396-2623535

Orphan

Consensus_repeat	Method
GGTAGCGGCCGACCTTGGTCGGCGCTGTGAGTGCGTGTCGACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP037858_5

>merge|NZ_CP037858|5|2623396-2623535|CRISPRCasFinder
GGTAGCGGCCGACCTTGGTCGGCGCTGTGAGTGCGTGTCGACCAAGGTCGACACCTACCGAGGGGCCTAGCGCGCAGCGGTCGCCATGCGCGGCCCTGGTAGCGGCCGACCTTGGTCGGCGCTGTGAATGCGTGTCGACC

>NZ_CP037858|5|5|2623396-2623535|CRISPRCasFinder
GGTAGCGGCCGACCTTGGTCGGCGCTGTGAGTGCGTGTCGACC	AAGGTCGACACCTACCGAGGGGCCTAGCGCGCAGCGGTCGCCATGCGCGGCCCT
GGTAGCGGCCGACCTTGGTCGGCGCTGTGAATGCGTGTCGACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_142807172.1\|2628938_2629622_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|223710
NZ_CP037858.1\|WP_005407930.1\|2630962_2631478_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	unknown	unknown	gnl\|CDD\|179953
NZ_CP037858.1\|WP_005407925.1\|2626757_2627021_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_005407919.1\|2620393_2620873_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|183009
NZ_CP037858.1\|WP_099552571.1\|2621022_2622327_+\|D-amino-acid-dehydrogenase	unknown	unknown	gnl\|CDD\|234819
NZ_CP037858.1\|WP_099552568.1\|2618043_2618898_-\|flagellar-motor-stator-protein-MotA	unknown	unknown	gnl\|CDD\|181655
NZ_CP037858.1\|WP_099552566.1\|2616476_2616971_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_049432331.1\|2618989_2619457_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NZ_CP037858.1\|WP_099552567.1\|2617071_2618040_-\|flagellar-motor-protein-MotB	unknown	unknown	gnl\|CDD\|236365
NZ_CP037858.1\|WP_142807167.1\|2619597_2619969_+\|classical-arabinogalactan-protein-4	unknown	unknown	gnl\|CDD\|237030
NZ_CP037858.1\|WP_142807170.1\|2623542_2624109_-\|DUF3016-domain-containing-protein	unknown	unknown	gnl\|CDD\|378666
NZ_CP037858.1\|WP_099552574.1\|2624352_2626341_+\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|236842
NZ_CP037858.1\|WP_142807168.1\|2620088_2620286_+\|lana-protein	unknown	unknown	gnl\|CDD\|372724
NZ_CP037858.1\|WP_099552565.1\|2616187_2616463_-\|DUF4031-domain-containing-protein	unknown	unknown	gnl\|CDD\|379076
NZ_CP037858.1\|WP_142807169.1\|2622305_2623373_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143500
NZ_CP037858.1\|WP_099552575.1\|2626384_2626675_+\|DUF3247-family-protein	unknown	unknown	gnl\|CDD\|371627
NZ_CP037858.1\|WP_099552576.1\|2627179_2628244_+\|methyltransferase	unknown	unknown	gnl\|CDD\|225370
NZ_CP037858.1\|WP_099552578.1\|2629754_2630963_-\|beta-ketoacyl-ACP-synthase-I	unknown	unknown	gnl\|CDD\|181184
NZ_CP037858.1\|WP_142807171.1\|2628240_2628942_+\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211327
NZ_CP037858.1\|WP_142807173.1\|2631669_2632758_+\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_142807172.1\|2628938_2629622_+\|HAD-IA-family-hydrolase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	4.46497e-60
NZ_CP037858.1\|WP_005407930.1\|2630962_2631478_-\|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA	gnl\|CDD\|179953	PRK05174, PRK05174, bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase.	3.90362e-120
NZ_CP037858.1\|WP_005407919.1\|2620393_2620873_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|183009	PRK11169, PRK11169, leucine-responsive transcriptional regulator Lrp.	2.38136e-70
NZ_CP037858.1\|WP_099552571.1\|2621022_2622327_+\|D-amino-acid-dehydrogenase	gnl\|CDD\|234819	PRK00711, PRK00711, D-amino acid dehydrogenase.	0
NZ_CP037858.1\|WP_099552568.1\|2618043_2618898_-\|flagellar-motor-stator-protein-MotA	gnl\|CDD\|181655	PRK09110, PRK09110, flagellar motor stator protein MotA.	1.10792e-163
NZ_CP037858.1\|WP_142807173.1\|2631669_2632758_+\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NZ_CP037858.1\|WP_049432331.1\|2618989_2619457_-\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	2.01048e-77
NZ_CP037858.1\|WP_099552567.1\|2617071_2618040_-\|flagellar-motor-protein-MotB	gnl\|CDD\|236365	PRK09041, motB, motility protein MotB.	7.61108e-165
NZ_CP037858.1\|WP_142807167.1\|2619597_2619969_+\|classical-arabinogalactan-protein-4	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.000127768
NZ_CP037858.1\|WP_142807170.1\|2623542_2624109_-\|DUF3016-domain-containing-protein	gnl\|CDD\|378666	pfam11454, DUF3016, Protein of unknown function (DUF3016). This is a bacterial family of uncharacterized proteins.	1.58036e-64
NZ_CP037858.1\|WP_099552574.1\|2624352_2626341_+\|PAS-domain-S-box-protein	gnl\|CDD\|236842	PRK11091, PRK11091, aerobic respiration control sensor protein ArcB; Provisional.	6.58033e-63
NZ_CP037858.1\|WP_142807168.1\|2620088_2620286_+\|lana-protein	gnl\|CDD\|372724	pfam13779, DUF4175, Domain of unknown function (DUF4175).	0.00338034
NZ_CP037858.1\|WP_099552565.1\|2616187_2616463_-\|DUF4031-domain-containing-protein	gnl\|CDD\|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	6.09218e-31
NZ_CP037858.1\|WP_142807169.1\|2622305_2623373_+\|alanine-racemase	gnl\|CDD\|143500	cd06827, PLPDE_III_AR_proteobact, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases. This subfamily is composed mainly of proteobacterial alanine racemases (EC 5.1.1.1), fold type III PLP-dependent enzymes that catalyze the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. hese proteins are similar to other bacterial ARs and are fold type III PLP-dependent enzymes containing contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	0
NZ_CP037858.1\|WP_099552575.1\|2626384_2626675_+\|DUF3247-family-protein	gnl\|CDD\|371627	pfam11607, DUF3247, Protein of unknown function (DUF3247). This family of proteins is the protein product of the gene XC5848 from Xanthomonas campestris. The protein has no known function however its structure has been determined. The protein adopts a Lsm fold however differences with the fold were observed at the N-terminal and internal regions.	4.88527e-23
NZ_CP037858.1\|WP_099552576.1\|2627179_2628244_+\|methyltransferase	gnl\|CDD\|225370	COG2813, RsmC, 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis].	1.33553e-67
NZ_CP037858.1\|WP_099552578.1\|2629754_2630963_-\|beta-ketoacyl-ACP-synthase-I	gnl\|CDD\|181184	PRK07967, PRK07967, beta-ketoacyl-ACP synthase I.	0
NZ_CP037858.1\|WP_142807171.1\|2628240_2628942_+\|pseudouridine-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	1.07244e-74

>NZ_CP037858.1|WP_142807169.1|2622305_2623373_+|alanine-racemase
MRPARALIDLGALRSNYRLARELGGGKALAIIKADAYGHGAVRCAQALEDEADGFGVATIEEALELRQAGIRAPILLLEGIFEPSDMALVAEHDFWFAVGSPWQLEAVAAFDSPRPLTVWLKLDSGMHRLGLDVDSFRAAHARLSALPQVERIVLMTHLARADELDSERTHEQAATFARAIDGLEGETSVCNSPALLGWPDVRSDWVRPGLMLYGANPLPEASEITARLRPVMTMQSKVIAERWIEAGEPVGYGARFVSKARTRVGVVALGYADGYPQFAPNGTPVLIDGQPGALIGRVSMDMLTVDLTAHAQAGIGSVVELWGSAPTLSELAPRCGVSAYQLPCAVKRVAKVYV
>NZ_CP037858.1|WP_099552571.1|2621022_2622327_+|D-amino-acid-dehydrogenase
MRVLVLGSGVIGTTSAWYLRQAGFEVTVIDRQPGPALETSFANAGQLSFGYTSPWAAPGVPKKAIGWLFEKHAPLAIRPGMDLAQYRWLWQMLRNCTHERYAINKARMVRMSEYSRDCLNELRAQIGIEFEGRDLGTTQLFRTQQQLDASAQDIEILAQYGVPYEVLDRAGIIQAEPALAHVDGLVGALRLPRDQTGDCQLFTRRLAQMCVDAGVEFRFDQDITGLEFDGDRITGVRIDGKLETADRFVVALGSYSPALVAPLGMRLPVYPLKGYSLTLPITDPAMAPTSTILDESYKVAVTRFDDRIRVGGMAEVAGFDLSLSQRRRETLELVVSDLYPKGGDLSRAQFWTGLRPATPDGTPVIGATPFRNLYLNTGHGTLGWTMACGSGRYLADLMSARQPQISTEGLDIFRYGQYGHAPQHENRTCVLPAR
>NZ_CP037858.1|WP_005407919.1|2620393_2620873_-|winged-helix-turn-helix-transcriptional-regulator
MATRTRELDKIDRKILRILQAEGRISFTELGERVGLSTTPCTERVRRLEREGVITGYHAHLDPAAVKASLLVFVEISLAYKSGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEMASYRKLLGSTLLTLPHVRESKSYIVMEEVKETLSLPIPD
>NZ_CP037858.1|WP_142807168.1|2620088_2620286_+|lana-protein
MSFVHWIAIMKNQQNRHPGKEPQGRNPQQQQQQQQQQQQQQMEPQQSHKGGKQQEQRPQKHPQQR
>NZ_CP037858.1|WP_142807167.1|2619597_2619969_+|classical-arabinogalactan-protein-4
MKSPLPLLLIALLPASALAQVPTADPTATRSSSTVAPTPVAPPPQAARPQPQVLPSPQPAQPIKSTGPAQVAPTPVPKPVDKVYDRNGRIIPGVRPAGPNRVFDSRTGRYLDSVPQGDGQQIR
>NZ_CP037858.1|WP_049432331.1|2618989_2619457_-|peptide-methionine-(R)-S-oxide-reductase-MsrB
MTAFDLTPPTATQTEALVAGLSSEERRVLLQHGTEAPFCGVFLDNKREGVYCCRLCALPLFRSSTKFDSGTGWPSFFAPFDPAHVREIRDTSHGMVRTEITCARCGSHLGHVFPDGPPPTYERHCLNSVSLSFTGNGEPWPDPLQRGGAEAGVAG
>NZ_CP037858.1|WP_099552568.1|2618043_2618898_-|flagellar-motor-stator-protein-MotA
MLIIVGFLVVIISVIGGYLGAHGRLGALWQPYELVIIGGAALGAFLVGTPAKTVKQTLQAMVGVFKGPRYKQQDYIDVLSLLYELLNKARREGFMALEDHVERPAESALFGNYPKVQADHHLIDFITDCLRLMIGSNIEPHELEPLLELELEKHHAEAMAPSQVMNKVADGLPGFGIVAAVLGIVITMGSIGGDIVEVGGHVAGALVGTFLGILLGYGFVGPMAAAMEARAEQDSRIYESVKTALLACLRGYNPKIALEFARKTLPSNVRPAFSDFEQHLKTVK
>NZ_CP037858.1|WP_099552567.1|2617071_2618040_-|flagellar-motor-protein-MotB
MAENKPTVIVRRVKKAGHAAHHGGSWKVAYADFVTAMMAFFLVLWLMATTNKNDRAAISEYFRNPSPLSGQNATPAPGMAGPGGASTSMIKLGGATDISRGNSNDPFQNQKEAVPQPVDQQQRDKQQLEQLMKELQEAISRSQALEPFKDQLLLDLTPEGLRIQIVDKQNRPMFDLGSATLKPYTQQILHELAEYLNHVPNRISLTGHTDITAYSAARGYGNWELSADRANAARRALVDGGLDDSKITRVVGLSSSVLFDKTDPQNPINRRISIVVMTRAAEEAALAGAGPQVGLSAPTVDPDVQAAQGKAPAEAAAPAVAR
>NZ_CP037858.1|WP_099552566.1|2616476_2616971_-|hypothetical-protein
MSQNSKAKRDKRKKQQAKRPFLRLNAQQQVQNHAVLTNEDGQVVAAIGLQGREWLLAIGGQTMGNAENPVPMLAMLKHLSNVQEKEGRKVNLEYSELLQKLLDTLAAESGQTADEYLDKLVAEFEGVDAAEGEEGEAAEGDVAEAAAADAEAAPAADSDSKPQA
>NZ_CP037858.1|WP_099552565.1|2616187_2616463_-|DUF4031-domain-containing-protein
MTVYVDDAVHPWRGQRWAHLMADTLPELHAMAAQLGIPARAFQNKASGAHYDVTAELRAQAIALGARAISRHADRELVKAVIANARAQYRP
>NZ_CP037858.1|WP_142807170.1|2623542_2624109_-|DUF3016-domain-containing-protein
MNRSLATALLLAGALMAGGANAAPRAVTDPEAPRALQADGPVSVKWDDPAKFTEIRQSSNRFEAERGDWVQQLARYVQTTAAKPLQPGQTLDVTLVDIKRAGDYEPWHGPRGRDIRIMRDIYPPRITLQYTLKDASGRIVSEGDARLSDTGYLHNVGLKSESDPLRYEKRLIDDWVKRQLASQATAAR
>NZ_CP037858.1|WP_099552574.1|2624352_2626341_+|PAS-domain-S-box-protein
MMVPAPEPDLHHGVLERINAGFCVIQVLFEGDRAVDYRFIEVNDAFERHTGLKDARGQRMTVLEPHHEQDWFRIYGEVARSGRPAQFEMEARALGRSFAVDAVRVGRPGEDKVGILFFDITARKQMEVELGESEARFSALADGLPMPVWVLDERGHARFVNSAFSEFFGGDETRVPEDVWRGLVHPDDASVFEYELQEALKAQRSMHALVRARRADGQWRWLEMNARPRFSRMGRFIGLAGSSPDVTERREIELAREELLQSERAARSAAENMARLKDEFLATLSHELRTPLTTILGWSELLLQRVDNTSPLYKGLNVIANSAGAQKRLISDMLDLSSMLLGKVQLEVEVLDLRTLLGEAIGAQELVAEGKALDVHLQLPEEPSPVLGDATRLQQVFWNLLSNAIKFTPAEGRIDVQLQADGNHWVITVRDTGDGIAPEFLNHLFSRFRQADGTTTRRHGGLGLGLAIVQQLVELHGGTVAAASEGHGHGATFTVRLPQHLPDAERRPLREVISGPILEPVIVEPYPLRGMHVLAVEDQPEVLEYLRRMLEEQGASVSAASSAGEALALLADTGHLQYHVMLTDIGMPGMDGYGLVRTLREDMGVDAAMLPAVAVTALARADDRRRALASGFQEHVAKPYSVAQLVAAVRKVQVPRADSALH
>NZ_CP037858.1|WP_099552575.1|2626384_2626675_+|DUF3247-family-protein
MSRTAPRIHTDPAQIARLEALLPQLEGETQVELTLHDGRRLLGTVAVKPTVQQYRNDAGDEGSNGQLRLDDYDTPVQQHHVWLDEIASIRRLPPRV
>NZ_CP037858.1|WP_005407925.1|2626757_2627021_-|hypothetical-protein
MRALFVGGVVDNSEMDLEGSHPPVHYPEDTGGGHSRYRLHQVGHGADGSVAYAVYGAPDLADDEVARVAEERAYARRFEATPTLFEH
>NZ_CP037858.1|WP_099552576.1|2627179_2628244_+|methyltransferase
MASSDDAPLQTLFLPFSQGALRWPEGPVAFLRARDGWPLREVAGNREVHCEQSFAPFAQPLQQAAGWTVSGQLDDAAGKGRYPLVLVLPPRQREEARALFARALALVADGGRIVACQSNNEGARSGEGDLKQLAGLGGSLTKNHCRVYWTAPLQGQHDADLARRWLALDAVRPIVGGRFLSRPGVFAWDRIDPASALLAEHLPADLAGRAADLGAGYGYLSRELLERCPKITALDLYEAEQRALALAELNLAPPPRPLPLRFLWQDVTAGIEPGYDVIISNPPFHTPSRADRPDIGQRFIAVAAQALRPGGRLYVVANRHLPYEYTLNESFGAVRVIAERDGFKLVEAVKGKGR
>NZ_CP037858.1|WP_142807171.1|2628240_2628942_+|pseudouridine-synthase
MKLVKHIANLGYGSRKQVQWMFREGRVTDADGEVLYADDQVPHEAIRVDGEPLDPPVGLSIALHKPAGYTCSTKDTGRLIYDLLPQRFRDRDPVLSTVGRLDRETSGLLLLTDDGGLLHRIISPKSKLPKVYEVELSDDLRGDEVALFASGTLMLESEKTPLLPAELEVLDARRARLVLHEGRYHQVRRMFAATGNHVQALHRSRVGGLDLQGLDEGQWRQLTSTDLDTLFAP
>NZ_CP037858.1|WP_142807172.1|2628938_2629622_+|HAD-IA-family-hydrolase
MTTIAALPFLPDAVIFDMDGLMIDSERVSLACWSQAADEFGLGLDEAVFLRMVGLGDRDTHALLRAQGIEDSVIEAVAARCHELYEARTQTGLPLRPGILELLELLKAHAIPRAVATTTRQPRANRKLAAAGLLPYFDAVITSGDVAQPKPAPDIYLLAARRLGQAPERCLALEDSPAGTRAALAAGMTVIQVPDLVHPDEELRALGHRIVGSLVDAHGLLLPLLPK
>NZ_CP037858.1|WP_099552578.1|2629754_2630963_-|beta-ketoacyl-ACP-synthase-I
MRRVVITGMGITSCLGNDLDTVSAALREGRSGITALADHAEAGLRSQVGGRVDLDLDALIDRKQKRFMSDAAAFAYLAMRDAIADAGLSTEQVSSLRTGLIAGSGGGSSEWQIGAVDLLRERGVRKVGPYMVPRTMCSTVSACLATAYQIKGVSYSLSAACATSAHCIGAAADMIRHGAQDIMFAGGGEDLHWSMSVMFDAMGALSTSFNETPASASRPYDKDRDGFVIAGGGGMLVLEDYDHAVARGAHIHAELIGYGVTSDGADMVAPSGEGAVRCMKMALQGIDRPLDYLNTHGTSTPLGDVTELNAIREVFGDAVPPLSSTKALSGHSLGAASVHEAIYCLLMMRDGFVAGSANIGELDPKVESFPILRQSREQKLDTVMSNSFGFGGTNAALVFGRV
>NZ_CP037858.1|WP_005407930.1|2630962_2631478_-|3-hydroxyacyl-[acyl-carrier-protein]-dehydratase-FabA
MTRLHAFNREQLLASARGELFGTAAGRLPNDPMLMFDRITDIREDGGPHGKGMVRAELDIRPDLWFFGCHFIGDPVMPGCLGLDAMWQLTGFFLTWLGAPGKGRALGCGEVKFTGQVLPEAKLVRYEIDISRVINRKLVMAQSDARMYVDDREIYSARDLRVGLFTETGSF
>NZ_CP037858.1|WP_142807173.1|2631669_2632758_+|DNA-polymerase-IV
MTRLRKIIHVDMDAFYASVEQRDDPSLRGKPVVVAWRGARSVVCAASYEARVFGVRSAMPAVRAERLCPDAVFVPPDFARYKAVSQQVRAIFLRHTDLVEPLSLDEAYLDVTEPKSGIELATDIARTIRAQIREETNLTASAGIAPNKFLAKIASDWRKPDGQFVIPPQRVDAFLAPLPVNRVPGVGKVMEGKLAARGIVTCGDLRQWALIDLEEAFGSFGRSLYNRARGIDERPVEPDQQVQSISSEDTFAEDLLLEDLTEAIVQLAGKTWNATRKTERIGHTVVLKLKTAQFRILTRSFTPERPPESMEELRDIALALRARVDLPAETRYRLVGVGLGGFREKEPVVQGELFEHTQTDRS

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Crispr_ID: NZ_CP037858_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_6

2666839-2667053

Orphan

Consensus_repeat	Method
CGACGCCAAGCTGGCCCGCCAGGAAGCCGAGC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP037858_6

>merge|NZ_CP037858|6|2666839-2667053|PILER-CR
CGACGCCGCGCGCGCCCGCCAGGAAGCCGAACAGCTGCGCATGCAGGCACAGATGCAGGCCGAGGAGGCTGAACGCCTGCGCCAGGCTGCCGAGGCCGAGACCCTGGCCCGCCAGGACGCCGAGAACGCCCTGACCAGCGTAGCCGGCAAGCAGCAGCAGCGCCTCAGCGCCGCCCAGCAGAACGCCGCCAAGCTGGCCCGCGAGGAAGCCGAGC

>NZ_CP037858|6|1|2666839-2667053|PILER-CR
CGACGCCGCGCGCGCCCGCCAGGAAGCCGAAC	AGCTGCGCATGCAGGCACAGATGCAGGCCGAGGAGGCTGAACGCCTGCGCCAGGCTGCCGAGGCCGAGACC
CTGGCCCGCCAGGACGCCGAGAACGCCCTGAC	CAGCGTAGCCGGCAAGCAGCAGCAGCGCCTCAGCGCCGCCCAGCAGAACGCCGCCAAG
CTGGCCCGCGAGGAAGCCGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_099490736.1\|2663125_2664115_+\|2-keto-4-pentenoate-hydratase	unknown	unknown	gnl\|CDD\|223257
NZ_CP037858.1\|WP_142807191.1\|2676934_2678959_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NZ_CP037858.1\|WP_142807188.1\|2669740_2670913_+\|cystathionine-gamma-synthase	unknown	unknown	gnl\|CDD\|366438
NZ_CP037858.1\|WP_142807190.1\|2674743_2676915_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|366154
NZ_CP037858.1\|WP_142807189.1\|2672500_2674741_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|379312
NZ_CP037858.1\|WP_099552594.1\|2651624_2653526_+\|asparagine-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|132152
NZ_CP037858.1\|WP_049444904.1\|2654420_2654783_-\|6-carboxytetrahydropterin-synthase-QueD	unknown	unknown	gnl\|CDD\|376501
NZ_CP037858.1\|WP_099552598.1\|2660841_2662263_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236722
NZ_CP037858.1\|WP_005407964.1\|2667709_2667946_+\|YdcH-family-protein	unknown	unknown	gnl\|CDD\|377305
NZ_CP037858.1\|WP_142807185.1\|2654975_2657615_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|366183
NZ_CP037858.1\|WP_142807192.1\|2679005_2680016_-\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|187558
NZ_CP037858.1\|WP_099551436.1\|2664889_2666017_-\|PilT/PilU-family-type-4a-pilus-ATPase	unknown	unknown	gnl\|CDD\|227341
NZ_CP037858.1\|WP_142807193.1\|2680197_2681796_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_005407961.1\|2666138_2666504_+\|DUF4398-domain-containing-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_099551438.1\|2664129_2664813_+\|maleylacetoacetate-isomerase	unknown	unknown	gnl\|CDD\|273527
NZ_CP037858.1\|WP_142807186.1\|2657689_2660284_+\|peptidase-M14	unknown	unknown	gnl\|CDD\|349457
NZ_CP037858.1\|WP_142807187.1\|2668246_2669617_+\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223110
NZ_CP037858.1\|WP_012509968.1\|2671774_2672500_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213187
NZ_CP037858.1\|WP_099552595.1\|2653957_2654305_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_059036192.1\|2670909_2671770_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224596

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_099490736.1\|2663125_2664115_+\|2-keto-4-pentenoate-hydratase	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.3146e-36
NZ_CP037858.1\|WP_142807191.1\|2676934_2678959_+\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	9.69721e-33
NZ_CP037858.1\|WP_142807188.1\|2669740_2670913_+\|cystathionine-gamma-synthase	gnl\|CDD\|366438	pfam01053, Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme. This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.	0
NZ_CP037858.1\|WP_142807190.1\|2674743_2676915_+\|glycosyltransferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	4.46169e-13
NZ_CP037858.1\|WP_142807189.1\|2672500_2674741_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.7025e-14
NZ_CP037858.1\|WP_099552594.1\|2651624_2653526_+\|asparagine-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|132152	TIGR03108, eps_aminotran_1, exosortase A system-associated amidotransferase 1. The predicted protein-sorting transpeptidase that we call exosortase (see TIGR02602) has distinct subclasses that associated with different types of exopolysaccharide production loci. This model represents a distinct clade among a set of amidotransferases largely annotated (not necessarily accurately) as glutatime-hydrolyzing asparagine synthases. Members of this clade are essentially restricted to the characteristic exopolysaccharide (EPS) regions that contain the exosortase 1 genome (xrtA), in genomes that also have numbers of PEP-CTERM domain (TIGR02595) proteins.	1.96636e-120
NZ_CP037858.1\|WP_142807187.1\|2668246_2669617_+\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223110	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism].	2.69958e-131
NZ_CP037858.1\|WP_099552598.1\|2660841_2662263_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|236722	PRK10590, PRK10590, ATP-dependent RNA helicase RhlE; Provisional.	2.02086e-174
NZ_CP037858.1\|WP_005407964.1\|2667709_2667946_+\|YdcH-family-protein	gnl\|CDD\|377305	pfam04325, DUF465, Protein of unknown function (DUF465). Family members are found in small bacterial proteins, and also in the heavy chains of eukaryotic myosin and kinesin, C terminal of the motor domain (Myosin pfam00063, Kinesin pfam00225). Members of this family may form coiled coil structures.	6.81491e-09
NZ_CP037858.1\|WP_142807185.1\|2654975_2657615_+\|TonB-dependent-receptor	gnl\|CDD\|366183	pfam00593, TonB_dep_Rec, TonB dependent receptor. This model now only covers the conserved part of the barrel structure.	1.30102e-36
NZ_CP037858.1\|WP_142807192.1\|2679005_2680016_-\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.19914e-177
NZ_CP037858.1\|WP_099551436.1\|2664889_2666017_-\|PilT/PilU-family-type-4a-pilus-ATPase	gnl\|CDD\|227341	COG5008, PilU, Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion].	2.51601e-167
NZ_CP037858.1\|WP_049444904.1\|2654420_2654783_-\|6-carboxytetrahydropterin-synthase-QueD	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	2.12313e-49
NZ_CP037858.1\|WP_099551438.1\|2664129_2664813_+\|maleylacetoacetate-isomerase	gnl\|CDD\|273527	TIGR01262, Maleylacetoacetate_isomerase, maleylacetoacetate isomerase. Maleylacetoacetate isomerase is an enzyme of tyrosine and phenylalanine catabolism. It requires glutathione and belongs by homology to the zeta family of glutathione S-transferases. The enzyme (EC 5.2.1.2) is described as active also on maleylpyruvate, and the example from a Ralstonia sp. catabolic plasmid is described as a maleylpyruvate isomerase involved in gentisate catabolism. [Energy metabolism, Amino acids and amines].	1.39107e-110
NZ_CP037858.1\|WP_142807186.1\|2657689_2660284_+\|peptidase-M14	gnl\|CDD\|349457	cd06238, M14-like, Peptidase M14-like domain; uncharacterized subgroup. Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. Two major subfamilies of the M14 family, defined based on sequence and structural homology, are the A/B and N/E subfamilies. Enzymes belonging to the A/B subfamily are normally synthesized as inactive precursors containing preceding signal peptide, followed by an N-terminal pro-region linked to the enzyme; these proenzymes are called procarboxypeptidases. The A/B enzymes can be further divided based on their substrate specificity; Carboxypeptidase A-like (CPA-like) enzymes favor hydrophobic residues while carboxypeptidase B-like (CPB-like) enzymes only cleave the basic residues lysine or arginine. The A forms have slightly different specificities, with Carboxypeptidase A1 (CPA1) preferring aliphatic and small aromatic residues, and CPA2 preferring the bulky aromatic side chains. Enzymes belonging to the N/E subfamily enzymes are not produced as inactive precursors and instead rely on their substrate specificity and subcellular compartmentalization to prevent inappropriate cleavage. They contain an extra C-terminal transthyretin-like domain, thought to be involved in folding or formation of oligomers. MCPs can also be classified based on their involvement in specific physiological processes; the pancreatic MCPs participate only in alimentary digestion and include carboxypeptidase A and B (A/B subfamily), while others, namely regulatory MCPs or the N/E subfamily, are involved in more selective reactions, mainly in non-digestive tissues and fluids, acting on blood coagulation/fibrinolysis, inflammation and local anaphylaxis, pro-hormone and neuropeptide processing, cellular response and others. Another MCP subfamily, is that of succinylglutamate desuccinylase /aspartoacylase, which hydrolyzes N-acetyl-L-aspartate (NAA), and deficiency in which is the established cause of Canavan disease. Another subfamily (referred to as subfamily C) includes an exceptional type of activity in the MCP family, that of dipeptidyl-peptidase activity of gamma-glutamyl-(L)-meso-diaminopimelate peptidase I which is involved in bacterial cell wall metabolism.	3.19537e-96
NZ_CP037858.1\|WP_012509968.1\|2671774_2672500_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213187	cd03220, ABC_KpsT_Wzt, ATP-binding cassette component of polysaccharide transport system. The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.	2.88945e-95
NZ_CP037858.1\|WP_059036192.1\|2670909_2671770_+\|ABC-transporter-permease	gnl\|CDD\|224596	COG1682, TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	3.33261e-47

>NZ_CP037858.1|WP_005407961.1|2666138_2666504_+|DUF4398-domain-containing-protein
MRHSLYVMAFAFALSAPAWAQDGAMELAQARQAVDKATQADADQYAPDLIGLARQGLEQAQRAAGDRRERKNAPAMALRAAADADLARVRSEEATVTAQLQLRRNEVNQLQRQLSTGEDRR
>NZ_CP037858.1|WP_099551436.1|2664889_2666017_-|PilT/PilU-family-type-4a-pilus-ATPase
MDIGYFLKLMTEKNASDMFLTTGAPVYIKIEGKLYPLGNTGLPPGMVKKIAYSLMDEGQVPQFERELELNMAIALPDAGRFRVNVFKQRGEVGMVIRAIRSRIPSIEELNLPQVLKDVIMTPRGLVLVVGSTGSGKSTSLASMIDHRNSTTTGHILTIEDPIEYLHKHKMSIVNQREVGLDTHAFHNALKNAMREAPDVILIGEILDAETMEAAIAFAETGHLCLATLHSNNADQTIERILNFFPESAHKNVLMNLALNLRAVISQRLVKNKDGRRLPATEVLLNTPMIRDLLRRGQVHEIKAAMEGSLEEGMESFDQCLFRLAKAGTIEQEEALRAADSRDGLALKFRLSEGSSGEHDPYADFSAGAPSITHGF
>NZ_CP037858.1|WP_099551438.1|2664129_2664813_+|maleylacetoacetate-isomerase
MDILVDDGPVDDGIVLYTYWRSSAAYRVRIGLELKGLAWEARPVHLVREGGEQHLDAYRALNPQQLVPTLLHDGHTLTQSLAIVEYLEERFPQVPLLPADAAGRARVRALAQLVACDIHPINNLRVMQYLERDLELPADARTQWTLHWIAEGFQAMEALLANSSATGTFCHGDRPGLADLCLLPQLYNAHRFGLDLGPYPTLRRIEAACQALDAFDRARPENQADAA
>NZ_CP037858.1|WP_099490736.1|2663125_2664115_+|2-keto-4-pentenoate-hydratase
MKLGSLKEGGRDGTLIVVSRDLRHGVRATGIAATLQQALEDWSHIAPRLNALYESLNAGDADGVFDLDPQALAAPMPRAYEFVDGSAYLPHVERVRRARGAEVPESFYTDPLMYQATSAGFYGPRDAVKVVSEEYGIDLEAEIVVITDDVPMAATPEQAAGHIQLVGLVNDVSLRNLIPGELAKGFGFLQSKPRSALSPVFVTPDELGAAWQDSKVHLPLLTHINGQWFGAPEAGVDMQFNFAQLVAHAAKTRPLGAGTIVGSGTIANEDTSKGASCFAEQRVVETLRDGKPSTPFMSFGDVVRIEMLDAAGNSIFGAIEQRIEQAAKP
>NZ_CP037858.1|WP_099552598.1|2660841_2662263_-|DEAD/DEAH-box-helicase
MSFESLGLAPFLLRALAEQGYENPTPIQQQAIPLALAGRDLLAGAQTGTGKTAAFGLPLLQHLGTASQEVRSGPRKPRALILAPTRELATQVHDSLRGYSKYLRIPSACIYGGVGMGNQLDILRRGVDLLVACPGRLIDHLERRSIDLSGIELLVLDEADRMLDMGFLPSIKRILAKLPKQNRQTLLFSATFEDNIRQLALEFMRNPEQIQVTPKNTVAETITHRVHPVDGSRKRDLLLHLLAQDSREQTLVFARTKHGSDKLATFLEKSGIKTAAIHGNKSQGQRLRALGDFKAGRVTVLVATDIAARGIDINELPKVINFDLPMVAEDYVHRIGRTGRNGATGQAISLVAQDEVKLLRAITRLLGRDMDIRDVPGFELQTPIRWGNSAPGKAEHDTGERAPRKSHARRPHGDAPRHAHAGPKKAGGGRREGGGNGQQRAGAGAGQGQRRGGGGNGGGRGRGQGGNGGGRAG
>NZ_CP037858.1|WP_142807186.1|2657689_2660284_+|peptidase-M14
MSLHRRAVLPLLLAVAAVLSSPHPAQAQSAYFFPQVTDAAAFDAAVPTPEQFLGYPIGSRYTRHDQLVAYFQELAKRSDKISVREIGRSYEGRPLLIATVTAAGNHARLEQIRQQHATLADPAQPRSAAGDSPVVVWLGYSVHGNETSSAEAAMLTAYYLVANRSPETQQWLQQAVVLFDPAQNPDGRDRAANWHNAWASDPASADPADKEHVEPFPQGRTNHYFTDLNRDWLALTQQDSRPKVEVFHQWYPNVQIDFHEMGKDSTYYFEPSPKSMHSPLIPAASYEFNKTLAKYHAQALDALGSLYYTGENFDNFSPVYGSTYPDFHGAVGVTVEQASSRGRVQESVNGLLTFPFTIRNQVATGLGTVRGAVTERSGLFDLQKQFFQSALKQAAQQPVKSFVFGDAHDPALTRRLLELLLLHRIEVRALDRAVTVDGQRFDAGSAYVVPVQQAQFRLVHSIFAETPPIKGDVFYGSTSYAIAPAYGVAFAGSRSRIEGGARVAALPAEQGAVLGGQAGFAYAIDWRDYNAGRALAALQGKGVSARAAFQPFTTATAQGDISFAAGSLVIPVAGQSLQGAPLLEAVTSAAREAGVQVYALSSGRSREGIDLGSDGVKALRKPAVALVMGEGVAATEIGSAWFLLDQQLHLPASKLDPQQLGKVPLDRYTTIVLSGGTYTGVDATAVAALKRWVQAGGSLVTYGSASKWAIEQKLADGEKLGKEEDAADESRRAFGDQRDFAAIERVSGNILSADVDTSHPLAFGVPRRQLAINKENTVTLQPSTNPFSTVVRIDTPPRVNGYLSERNRARVAGSAWLLVSAQGQGNVVLFADDPAHRKYWHGTDRLLINAIFFGNLVNPSKARG
>NZ_CP037858.1|WP_142807185.1|2654975_2657615_+|TonB-dependent-receptor
MPKHTLLVAALAVALAAPLSAAAETSADASGEASTLAAVRVTGSNIKRTDTEASNPVQVIGRQQLEQTGKATVADVLRSISANTGNASNETTNNGWASGSAGIGLRGLSQKNTLVLLNGRRLANYGFPAGGLSDTFVDLNALPLVAVERIEVLKDGASAVYGSDAVAGVVNIITRQNFEGAEIGGSFGGADQGGLHEQNLKFVGGLGDLDTDGYNILFSLQGYNRERLDQDERNLTKSGIYTDAPGGRWNGWSAKGARYLVNGVSVPMLDANGNCPTGTTRVASAPIDGLAGDTCGFNQAPFTTLIPSTKRYQAYANGTFRLNDNVEAFGEVLYSQIKSAAWFGSSPFFTLESGRFALNANSGLAEPVSSLLPANNPYNPYGRAIPIEYTFFDLGGTIKTNRSTAYRGVFGLRGTTANWDWEVAAFGARSSERESVSGGFANRWALADALATGSYNLLNPAATPQSVRDSINIATLRPAESKLQGIDAKISGSLGHTWAGEIGFAAGAEWRREKLDSNNPWQIDAGLQVRPAIAEVHGQRQVSAAYAEVNVPLASTLELSAAARADHYDDFGDAFSPKIGLRWQPLDFLLVRASASKGFRAPSLSENSNSTSIAYGSVVDPRDPDVPGSRQNPTFFTVGNNELKPERTRSVNFGVVLSPWANTNVSVDYYRIQLDNLVGTNNTQTLVNDNVAGAVQRDERGKLQAVYNRYQNLSELKTSGIDVELRQRIPTAALGDFTVSSAYTHVRDYRRPTVVGGPLVDYAGSNLGATLPKDKATTTLDWKYGDFNAAVTWYYTSSYRQEASTAAKAVQQQVGSYSQYDLYLAYTGVDKLTVYAKVQNLADKTPPYDASFPGIRAPYDFSQYDLRGRYFTLGFDYRF
>NZ_CP037858.1|WP_049444904.1|2654420_2654783_-|6-carboxytetrahydropterin-synthase-QueD
MEIFKVFMLEAAHRLPNVPPGHKCARLHGHSFRVELKVEGEPGAQTGWIMDFGDVKAAFQPIYDRLDHHYLNDIPGLENPTSENLAVWIWNELKPSLPALSEITVHETCTSGCRYRGPAA
>NZ_CP037858.1|WP_099552595.1|2653957_2654305_-|hypothetical-protein
MAAAFSDRFSDATRQLAAAATRANRLALENAESMFGVQLKVMERNLTATGGWLGELARGEDAAGTLNKGTQLWQDNLQRLGQAQQDMVGLGLQASKAWSELVQGYNQSTADANSH
>NZ_CP037858.1|WP_099552594.1|2651624_2653526_+|asparagine-synthase-(glutamine-hydrolyzing)
MSGVVGAWLPPAADEHLLQQLAPMLRALQQRGRGRIGYWTDAEAGLALGHCRAPTDTPLQPLSSDCGRYVLCLDGRLYNRADLQSQLRDLPRSCSDARLLLQAIVEWGVERALSRIEGAFGFSVWDRESRALWLARDPVGERPLYYGWYQGQFLFASEMKALQAFAGFAPSIDQDALSLLLRHDYVPAPHTIYRGIHKLVAGAMLRIDLNDHAAGGSSQAAQGGSRYWCARDAMQSALQEPLQPAPSLEQATDQLEAVLQKAIAARMHSPLACGAFLSGGTDSSLVTAMMQAQSTLPIEAWTVGFDDPGHDESDWASQVARHLGVQHHLHRMDARQGLDLLQRLPQVWCEPFADASQLPTLLASELLGARKPVALTGDGGDELFFGHPSYGRALRNARLCGGLPDWVRDLARRSGNRMNVERGRLGGWRALVAEVAANDVEGHYLQRVTRWRQPAQVVLGAREPMTIFQQQDTALPAEARIQLLDFRMDLAEGILAKVDRAGMAAGVETRAPLLDMEVVRLAWRLPQHLKYHDGEHKLILKHLLARYLPEPLVYRPKRGFGPPMARWLAGPLRDWAEALLDPQLLRNQGCFDAARVRGIWEAFLRGERKWHTHLWNVLMFQAWHQHWHVNRGR
>NZ_CP037858.1|WP_005407964.1|2667709_2667946_+|YdcH-family-protein
MFEDQPQSEIDARRARDPEFRALHDQHRKLNKKCMDAELGVLPIDDVTLGRMKREKLLAKQRLLRMYETPLPTTSPTL
>NZ_CP037858.1|WP_142807187.1|2668246_2669617_+|pyridoxal-phosphate-dependent-enzyme
MPIHSSVLELIGQTPIVKAQRLDTGVCELYLKLESANPGGSIKDRIGLSMIEAAEQRGDLKPGATLVEGTAGNTGLGLALVAQQKGYKLILVVPDKMSREKIFNLKAMGAEVRLTRSDVAKGHPEYYQDLAKTIAEQTPGAYFINQFGNPDNPAAHEFGTGPEILEQMGGDLDAIVFGCGSSGTMTGLSRAFAKLSPKTELVLADPVGSILAEYINDGNLNDKSGSWLVEGIGEDFLPSISDFSRVRKAYAISDAESFHTARELLGKEGILGGSSTGTLLAAGLKYCQEQTTPKKVLVLVPDTGNKYLSKMYNDYWMLDNGFLQRPQHGDLRDLILRPYGQRDTVVIGPNDLLTTAYQRMKLYDVSQLPVMDGDQLVGIVDESDVLLHVYGDEARFRDTVSTAMVSKLDRLDVKSPIEALLPVFDRGQVAIVMDGNAFLGLITRIDLLNYLRRRVQ
>NZ_CP037858.1|WP_142807188.1|2669740_2670913_+|cystathionine-gamma-synthase
MSNATSQDRALALATLAIHGGQSPDPSTGAVMPPIYATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVASLEGGTRGFAFASGMAASSTVIELLDAGSHVVAMDDIYGGSFRLFERVRRRTAGLDFSFVDLTDLAAFEASITPKTKMVWIETPTNPMLKIVDIAAVAAIAKRHGLIVVVDNTFASPMLQRPLEMGADLVLHSATKYLNGHSDMVGGMVVVGDNAELAEQMAFLQNSVGGVQGPFDSFLALRGLKTLPLRMKAHCANALALAQWLEKHPAVEKVIYPGLPSHPQHELAGRQMAGYGGIVSIVLKGGFEAAKRFCEKTELFTLAESLGGVESLVNHPAVMTHASIPVARREQLGISDALVRLSVGVEDLGDLQVDLGEALK
>NZ_CP037858.1|WP_059036192.1|2670909_2671770_+|ABC-transporter-permease
MNNETILKAEIARRRVRISSHDTQMKALPAFIRDVSEGMAAWRAWTSLALLDIKHKYRRSVLGPFWITISMFVLILGIGLLYSQLFRMNLREYLPYIALGDIVWIYISTTVQEGCTTFTASENLIRSMRLPMTLHVMRLVTRTFIVFLHGAIAYLPFVIFLKIEPELVWLLALPGVALIVLATIPVTAIFGLLSARFRDLHPAIANFMQLGFFMTPIIWKADMLGPHRWVADINPIYHFIQIVRMPLMGQVPEAHSYYFVLAFIAAAFVIALPFLAANRHKISLWV
>NZ_CP037858.1|WP_012509968.1|2671774_2672500_+|ABC-transporter-ATP-binding-protein
MTFIEVVDCSVQLPIYGTNNRSMKGAIMSAVTGGRVAPTSRNVTVVDSLQNVTFNLREGDKLGLVGHNGAGKTTLLKTLAGVYEPTSGYIRSQGRVANLLDVTMGMDFEATGVENIRLKGLLHGLSRAEIQSKIPQICEFSGLGPYVNMPVRVYSSGMMVRLAFSIATSFDAEILLMDEWLGVGDADFNARAQQRLAEIVQKASILVLASHNQDIIAANCNRIMHLEHGRITSDQPIEARA
>NZ_CP037858.1|WP_142807189.1|2672500_2674741_+|methyltransferase-domain-containing-protein
MNTRNRDYWINRSGDLYADQQKIRREAGNSNYARQEAWLVGFLAERSEQLGRPVRVLDFGVGFGRLARLLPQHAFVDYFGFDISPAMVEPLLREPPVELAADIGRRIRVGSSLAEAMQGEQFDVIFTVSVLIHNDREQAADVLAQMRVLLAPGGRLCFIENRPVSISLLANLWHAGCWSHDFAGTLAPDMNVDVEDGILSDHAIYILHESAAGIPRQLRVPGARGFEPITAGDYLLRTLEATTAVARGMEVESATLGGDIAQMRDAVELYRQAEEHARTNLDIARQHLGDDVGLLDGIGHLTAAIDALPALAMRIGVLGGETSVQHAQSLGRIEALHAREATLVESLAQQERELEQAQARLDAAQSANQHLQWQQGLREQVRQALSSRMDEGAMPYLDAPVGGSASVGQPVPSVYEFNARRDMRFAQTVVGHERVCHIMHQEWFGIRAACGSLPGHKLAVTSTSAPDAGDVEEVARLLAANKVNRLVIHGFSDGMLQWVKGLAAAGFDRIYMVWHGAPSMWIHAEERRLFALAYKAVRTGLIRRVSVMRAGSHAALADVAGWQRQVYNMPPAYTGKRIPRRATGATVFIPSWNLIHKNIFTNAAAAAATGEVANIWLMADDFALPYRVDKNVKRLPKLSQLQMMEAMSQADAVMNASIVDCHPMVELEALAAGTPALRGRLGMDALEDHPYVEITQVADPLSVADVRQTLRRMLAAPAVEMDDMMSSYSRQMVALSFERYSEFMEI
>NZ_CP037858.1|WP_142807190.1|2674743_2676915_+|glycosyltransferase
MGLRVFVTRELFPFTAGGIGRVIANMLMTAPEEDRAEMAVLYVGDNVEADAFAVAHPGVTFLAWPHSRFQQVDERGEIFPPMPAFTHSMLHWESVHVLQGLLELERLKGPLEYVEFVDWGAPAFAATQEKLLGSALTTATLAVRLHTTDSILADFEPRVQSVHGLNLFDLERKALADCDLIVGQIAPVAEAFRVFYGFSEEEWTPRLRLHAPPVLLDTMQPTTQTTVIDDTTSLLFTSKLQDIKRPDTFIRGCIQFLRDRPRYQGNIVFLAHSFDVSYQEYVISLVPEDLRSRVVFARGVTGAAREKSISGAVCVFPSPWESFCLAAYEASLSGAACVLNAQNPAFGPGSPWRDGYNCSTFDGSAEDLARALSGLFESAVGRLSPVEVPKDPLPWKGLDPVAVPAAVPLDRQLTVVVVNRDSAGRVLNSLDSILASNLTLDKLIVIDDASRDPRDIAVLDQLGSNDPRLSVHRLAVPVGDAVARNMGLALVETPFAGFVRGGDQLLPGFLNGAVSALASHPDFDVVVGQVGVTVDPDDVIAGNVAPDGFHIFYGEGRLAGLYENRLAPESYVIRTEAARRFAFDPVIPALEVWEMMLRACQSGARFMVTSAVNVLARHQGQPDERHLEQIQIAMRRRLQRKRVRVGSLEVPAYFIFGAHVSPSGFMGDASNAEMAYRLQALMESESVRYTLALARLLQKRAPWVLRLGKWSVQRLAPIYRRLR
>NZ_CP037858.1|WP_142807191.1|2676934_2678959_+|glycosyltransferase
MHVIVIQLACWRVGGERAALARARLRAIPAASVLIVGEGAPPADLLEECTERRKLCVDSPLHAMQGRRLPDVRRSGDAEQLGWSLAVMAALRALQQDVHLDCVEIPSCGALAYALLQERALSEVFDTTRVMLRFDGIQAIEVLRQGRNVEMAALMLMDMERMCLEQCDQVLVDSQAIAESLQRFLPGSQRPLHLQATLPEPAGLVSEHHAVGSALACVATEAPALRQCLRAISGYLQQNNDGLLQVSVVCQPALLSEVLHVVPAALRHRFQEAPADCLRASPMRVVMPDRWSAGSALARELLAHGHSLIVDVANPALAAAQGWEQGRTHLGYTDARGLFEALRASQQWVPTRHLRMGPSPPLPKLDVGTPGPAKVSVVVPCYNMGRWLPQTLRNIQRFSWSDLEVIVVDDGSTDPGTVQLIEELEASPTAGLRVVRLEFNQGLSAARNAGVAAAQGEFTLCLDADDLVSPEFVSIAVRALQRQPAHDFVVPRCAYFFGDESALDVNELRLGQGLPMVGAAFDSGTLGNRFSTATSLARTSVLRALGYDESLRSYEDWQLYRRALQQGSRFVVTNDVHFFYRQRPDSMIHDPAMRARHSLLYAEMVGGATLIGQGPVVSPNLLGALAAPPRIDGSSSGLLLGGVVEALDEMQALRRSRIVGLGYRLSALLRRLRR
>NZ_CP037858.1|WP_142807192.1|2679005_2680016_-|UDP-glucose-4-epimerase-GalE
MRVLVTGGAGYLGSHVCAELLLGGHEVTVVDDFSNARPDVGERLNMLTGRVVNIITGDIRNRATLDRAFLQQRPEAVMHFAALKAVGESAVVPLAYYDVNVAGTINLLQCMQRNACHKLVFSSSATVYGNSSHCPINESAPTSATSPYGRTKLFVEQIINDAKLADPLLQAINLRYFNPVGAHESGLLGEEPSGTPNNLMPYIAQVAAGLRSHVSVFGADYPTTDGTGIRDYIHVCDLATAHIRTLEALPNLSGLNALNLGTGIPYSVLDVIRAFSEASGRPVPYEIVGRRPGDIGECWADPSLAECRLGWSAKLDLAKMCRDTWRWQQILMSRSQ
>NZ_CP037858.1|WP_142807193.1|2680197_2681796_+|hypothetical-protein
MATPTAPLLRLTLLGVGLVLVLLPGVLLMRELLHIGMQEDAMIGLRHLRNMLEGSGFVYNRGESALGATNPLFWIFSFLAIKPFYLASPSLDVLVAHYYFCGFALLAAAIAFAMAAPSRTRTVSVAAMALLSVLFFWPLRFLYLGLEGPFMLVCVGVLGLLAVRSVGTRDGLLATLVGFLSWNRPEIALILIPAVLFYALLMSDKSSRIRVSVGYLAGAVAFPLMLKLVSGAYIAGTVQAKAYFGNPSPPYNLDFFVQRIIYLDSFIGLGGGVTVLLLVGIFASAIIGILDFLQGDRKQMPWVRGVYPAFVAGYSCFVLFIPSLWEWYVTFWLSFALVQYGVLISRGINCCFSVLRGNVGAAMLGVTIVLLSTSWLMGHRLATQRTEIVGWITQDAGFRGRLSKELNERWHARSVWMEAAGWQGYFNNARIFDEVGLVDDETQPLAQKYGCAYFVSALKELQPQFVIKRQFEMDRNVMLTPPRSCPNAPLFSNDADRLWFDSNYEAVEHYGTPAPGYFGEYSFLVLYRSRNK

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Crispr_ID: NZ_CP037858_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_7

2865842-2865940

Orphan

Consensus_repeat	Method
TCATCCACGCATGGCGTGGATCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP037858_7

>merge|NZ_CP037858|7|2865842-2865940|CRISPRCasFinder
TCATCCACGCATGGCGTGGATCTGCCTCATTGAAAGGCAAACAAAAAAGCCCGGGTGTCTGCACACCCGGGCTTCTTCATCCACGCATGGCGTGGATCT

>NZ_CP037858|7|6|2865842-2865940|CRISPRCasFinder
TCATCCACGCATGGCGTGGATCT	GCCTCATTGAAAGGCAAACAAAAAAGCCCGGGTGTCTGCACACCCGGGCTTCT
TCATCCACGCATGGCGTGGATCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_099553702.1\|2861959_2862955_-\|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl\|CDD\|129820
NZ_CP037858.1\|WP_142808103.1\|2870037_2872245_+\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	unknown	unknown	gnl\|CDD\|273808
NZ_CP037858.1\|WP_049444405.1\|2874365_2874719_-\|DMT-family-protein	unknown	unknown	gnl\|CDD\|377316
NZ_CP037858.1\|WP_142807267.1\|2863102_2863534_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_099553653.1\|2856023_2856824_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|277343
NZ_CP037858.1\|WP_099553661.1\|2861071_2861899_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|181382
NZ_CP037858.1\|WP_142807265.1\|2858076_2859084_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133022
NZ_CP037858.1\|WP_099553706.1\|2868421_2869393_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381369
NZ_CP037858.1\|WP_142807272.1\|2873877_2874363_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_142807273.1\|2874787_2877301_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669
NZ_CP037858.1\|WP_142807274.1\|2877297_2877945_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226647
NZ_CP037858.1\|WP_142807268.1\|2863643_2864561_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176164
NZ_CP037858.1\|WP_142807266.1\|2859080_2860931_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|287142
NZ_CP037858.1\|WP_099553672.1\|2872249_2872849_+\|Hemin-transport-protein	unknown	unknown	gnl\|CDD\|226243
NZ_CP037858.1\|WP_142807263.1\|2854311_2856027_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|153248
NZ_CP037858.1\|WP_142807270.1\|2866929_2868228_-\|NupC/NupG-family-nucleoside-CNT-transporter	unknown	unknown	gnl\|CDD\|224883
NZ_CP037858.1\|WP_142807264.1\|2856964_2858023_+\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|377294
NZ_CP037858.1\|WP_010481882.1\|2852775_2853987_-\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
NZ_CP037858.1\|WP_005412278.1\|2869653_2869848_+\|hemin-uptake-protein-HemP	unknown	unknown	gnl\|CDD\|378463
NZ_CP037858.1\|WP_142807271.1\|2872922_2873849_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_099553702.1\|2861959_2862955_-\|tRNA-dihydrouridine-synthase-DusB	gnl\|CDD\|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	7.7044e-149
NZ_CP037858.1\|WP_142808103.1\|2870037_2872245_+\|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor	gnl\|CDD\|273808	TIGR01786, hemoglobin-haptoglobin-binding_protein, TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein. This model represents a family of TonB-dependent outer membrane receptor/transporters acting on iron-containing proteins such as hemoglobin, transferrin and lactoferrin. Two subfamily models with a narrower scope are contained within this model, the heme/hemoglobin receptor family protein model (TIGR01785) and the transferrin/lactoferrin receptor family model (TIGR01776). Accessions which score above trusted to this model while not scoring above trusted to the more specific models are most likely to be hemoglobin transporters. Nearly all of the species containing trusted hits to this model have access to hemoglobin, transferrin or lactoferrin or related proteins in their biological niche. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	5.75267e-124
NZ_CP037858.1\|WP_049444405.1\|2874365_2874719_-\|DMT-family-protein	gnl\|CDD\|377316	pfam04342, DMT_6, Putative member of DMT superfamily (DUF486). This family contains several proteins of uncharacterized function. The family is represented in the Transport classification database as 2.A.7.34, though the exact nature of what is transported is not known.	1.51128e-57
NZ_CP037858.1\|WP_099553653.1\|2856023_2856824_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|277343	cd07398, MPP_YbbF-LpxH, Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain. YbbF/LpxH is an Escherichia coli UDP-2,3-diacylglucosamine hydrolase thought to catalyze the fourth step of lipid A biosynthesis, in which a precursor UDP-2,3-diacylglucosamine is hydrolyzed to yield 2,3-diacylglucosamine 1-phosphate and UMP. YbbF belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.87405e-70
NZ_CP037858.1\|WP_099553661.1\|2861071_2861899_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	8.4497e-26
NZ_CP037858.1\|WP_142807265.1\|2858076_2859084_-\|glycosyltransferase	gnl\|CDD\|133022	cd04179, DPM_DPG-synthase_like, DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily. DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.	7.63435e-44
NZ_CP037858.1\|WP_099553706.1\|2868421_2869393_+\|aldo/keto-reductase	gnl\|CDD\|381369	cd19143, AKR_AKR6C1_2, AKR6C family of aldo-keto reductase (AKR). Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.	0
NZ_CP037858.1\|WP_142807273.1\|2874787_2877301_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	6.70893e-175
NZ_CP037858.1\|WP_142807274.1\|2877297_2877945_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226647	COG4181, COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	1.51698e-97
NZ_CP037858.1\|WP_142807268.1\|2863643_2864561_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176164	cd08475, PBP2_CrgA_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 6. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.67342e-82
NZ_CP037858.1\|WP_142807266.1\|2859080_2860931_-\|hypothetical-protein	gnl\|CDD\|287142	pfam10131, PTPS_related, 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	0.00964645
NZ_CP037858.1\|WP_099553672.1\|2872249_2872849_+\|Hemin-transport-protein	gnl\|CDD\|226243	COG3720, HemS, Putative heme degradation protein [Inorganic ion transport and metabolism].	0.00264379
NZ_CP037858.1\|WP_142807263.1\|2854311_2856027_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|153248	cd07986, LPLAT_ACT14924-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.	6.52898e-57
NZ_CP037858.1\|WP_142807270.1\|2866929_2868228_-\|NupC/NupG-family-nucleoside-CNT-transporter	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	4.4302e-141
NZ_CP037858.1\|WP_142807264.1\|2856964_2858023_+\|metal-dependent-hydrolase	gnl\|CDD\|377294	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase. YdjM is a family of putative LexA-binding proteins. Members are predicted to be membrane-bound metal-dependent hydrolases that may be acting as phospholipases. It is a member of the SOS network, that rescues cells from UV and other DNA-damage. Expression of YdjM is regulated by LexA.	8.22822e-26
NZ_CP037858.1\|WP_010481882.1\|2852775_2853987_-\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
NZ_CP037858.1\|WP_005412278.1\|2869653_2869848_+\|hemin-uptake-protein-HemP	gnl\|CDD\|378463	pfam10636, hemP, Hemin uptake protein hemP. This is a bacterial family of proteins that are involved in the uptake of the iron source hemin.	2.47066e-16

>NZ_CP037858.1|WP_142807268.1|2863643_2864561_-|LysR-family-transcriptional-regulator
MLPTERLRGIEAFVATADAGSFTAAAERLHLTSSAVGKTIARLEARLGARLFERSTRRLRLTEAGEGFYRTCVRVLGELADAESVLVAHADAPVGRLRVDAPATFGRLKVWPLLLQLAAEFPQLHPQVTFSDRFSDLAEDGVDLAVRIGGPEPLPAPLGSRLLGYECLRFCASPAYLLRHGQPRSAAELAGHDGVLFGRADGSIGPWQVADGGQRSTPLQARARLVVGSAEAQVAAVEAGFGIAQLATWLVDDALARGSLVSILPSLDCRGLPLRLLWLQGRQRLPRVDVALDRLGAGLQIDPPR
>NZ_CP037858.1|WP_142807267.1|2863102_2863534_-|hypothetical-protein
MDGFPWLLVAAAGSAIAALLHIGCIAFGAAWYRYFGAGQRMVRLAQAGHWWPPLMTAGITAVLVAWTLYALAAAGWHSPLPASRLVLSGIALLLLLRAAMGFTLALLRPGYNGRRFWVVSSLACLSLGLAFALGTGQAWQSLG
>NZ_CP037858.1|WP_099553702.1|2861959_2862955_-|tRNA-dihydrouridine-synthase-DusB
MQIGPYTIAPNVVLAPMAGVTDKPFRLLCKRLGAGLAASEMTISDPRFWNTRKSIHRMDHDGEPAPISVQIAGTEPQQLAEAARYNVDHGAQIIDINMGCPAKKVCNAWAGSALMRDEQLVARILEAVVNAVDVPVTLKIRTGWDCDHRNGPLIARIAEDSGIAALAVHGRTRDQHYTGQAEYGTIAEIKAALRIPVIANGDIDSPQKAAYVLKETGVDAVMIGRSAQGRPWIFREVAHYLATGEELPPPSLAEVRDILLGHLHALHAFYGEPQGVRIARKHLGWYAKDRPENAAFRAVVNRAEDPQSQIALTTEYFDRLIAGEPALSSAA
>NZ_CP037858.1|WP_099553661.1|2861071_2861899_-|class-I-SAM-dependent-methyltransferase
MTPPISSPTYLHGFSGTEQQRLMTQARLLESSIFGQIDYSGARRLLEVGSGVGAQTEILLRRFPELHVTGVDLSETQLETARGNLSRTPWCSDRYTLQQADAGELPFEARSFDSAFLCWVLEHVPSPARVLSEVRRVLAPGSPVYITEVMNASFLLDPYSPHIWRYWMAFNDFQYDHGGDPFVGAKLGNLLLAGGFRDVHTEIKTIHLDNREPARRKTMIAFWEQLLLSAADQLLQAGSVDEETVEGMRREFRLVQNDPNAVFFYSFVQGRATVY
>NZ_CP037858.1|WP_142807266.1|2859080_2860931_-|hypothetical-protein
MDLTCGSMMNDNGRTPFPAQDPAQTGGLRPGQVRLLAGIMALLCILYVAFALTPSSYSLAYEYLGLAPQQPLLGTARYIRTDEWMVFTPYIQIAVNNDFGQVNAHSAYHESLRTFQALPLLDWGLLFKPYHWAFFLLPAANAYSFFFMFMAMAFLSGWALLLRQLRMPTPAAVLVSATLFFAPFVQVWWTSNAGAFALAPWAAVAWLGIGHRALRIAVSAYALAAWLIAVSYPPFIISSVLALAVLVLAVRRDAITVVRLVDAAIAGAIALAVFVGYFHDIIPIVRNTVYPGQRQSAGGGVGLTSLLAHLFPNLMTYRFAPLPLFKASNDCEIAVLGSLLPLFTLVLADGTRLREWAKSHRSSLLILAAGLLFIACWIFLPVPAVVGKLTTLSMVPPARALLAFGLLLNIACAMILVHCGVRLQRWRLLLLAALLMVGSLAKFLFGEGQFSRLHSAADAIPYLCLAALAVAARRPQLSMHATSLVLAAAALANLLGNGLFNPVQPAGPIFAMDRTAVLHSLQARGSASTTEGVLVAPGGFGGLLPGVGIPAVNHVLYLPQMDYFRRYFPSMSDEAFNFTFNRYHHITVAPEGDAPRVLQGDLVELPAKPLLAHPAR
>NZ_CP037858.1|WP_142807265.1|2858076_2859084_-|glycosyltransferase
MNPMTTTTPSASAPARIAVIIPCYKVTRQVLSVLAAIDDAVTAIYCVDDACPDGSGRLIQAEANDPRITVLFHQHNLGVGGAIKTGYRAAIADGMDILVKVDGDGQMDPALLMDFVAPIADGHADYTKGNRFWNLTHIRRMPPVRRLGNLLLSFMTKASSGYWQVFDPTNGYTAIHAKVASHLKLEAVSDRYFFETDMLFRLNTVRAVVQDVAMDAHYGDETSNLRIGRILGEFTFKHLRNTLKRIAYNYFLRDLSIASLELIAGSSLLAFGGLFGLYHWVRSAQADVATPVGTIMIAMVALISGLQFLLAFVGFDIANVPRQVLNRSIKLNRQP
>NZ_CP037858.1|WP_142807264.1|2856964_2858023_+|metal-dependent-hydrolase
MDSLTQIVLGGAVAAAIAPPGHRRAALLAGAALGTLPDLDALWLGFTAADPVANMIEHRSFSHSLLVLPWVAALIWWLFKRFGNGRVAQSPVRWFWAIQLALVTHPVLDAFTVYGTQLWWPLRPHPTMGSSVFIIDLGYTVWLLLACVLAWFGRARPWAGKVLGVALLVSSAYLGWGLIAKAQVYRAAQQSLAAMGLGDAPRFSVPMPFNTLLWRVVAMTPNGYVVGDRSLVADHGPMQFEGHPSNVQALREAQAIPAVQQLTWFNRGFMRAQVMDGRLVLSDLRMGLEPDYTFNFAVAQQVDGQWRPITPEQVRTDYSSPAARADAGRRLVAMWQRIWHEPAAAAPGAAHP
>NZ_CP037858.1|WP_099553653.1|2856023_2856824_+|UDP-2,3-diacylglucosamine-diphosphatase
MSALANLSPHRRAVFVSDVHLGSRHCHATELARFLSQLRCERLYLVGDIIDLWWMAHRRANWRQSHSEVIQALHALRRAGTEIIYIPGNHDASLRQVCGLMLPAMQVRRRAIHVTADGRRLLVAHGDDYDGVTHFGGLQEKFGDWLYYRILTGNQALNAVRRRLGMRYWSLSEFLKKRSGAAERYIERFVQAGLDDVRRRGLDGIVCGHIHRAALIERDGLVYANDGDWVESLTALAEDHDGALRLLDHNGQTLVELPGARMSQAA
>NZ_CP037858.1|WP_142807263.1|2854311_2856027_+|GNAT-family-N-acetyltransferase
MQELEQRLQQRFPDWFHGRRGQLARPLLRSVGRWSRLDQIEAFLQRSAGLRGFGFVAAGLEFIGGQYQVDPAALAKIPATGRLLIVANHPSGALDALALLDAVGRIRRDVRIVANDLLGAIAPLQDLLLPVRILGGKAQRGSLHAVEEALAAEQCVIVFPAGEVSRLSLRGIRDGRWQRGFVRFARAAGAPVLPVRVEARNSALFYGASTLFKPAGTALLAREMFTRRGRPLRLCIGEPMQLGKGGDPGAQLLAVRRALYALGRNGAAGGAAAVAGPEPLASPVPPSRVAAGIAAATQLGQTADGKQILLATCSADSPLLLELGRLRELTFRQVGEGTGRSRDLDDYDPQYEHIVIWDAAAQRIAGAYRIMRGAQALARHGLSGLYSASLFRYSDDAITHIAEGLELGRSFVVPDYWGSRSLDYLWQGIGAYLQCRPGIRYLFGAVSISAALPRDAREQLVAYYQRYYSGTAGLAESNRPFQYFAAPPSFGELDAGAAFDVLKANLAALGTGVPTLYRQYTDLCEPGGARFLAFGVDPDFSDSIDGLIEVDLCAIRPNKRKRYLRDAGTPA
>NZ_CP037858.1|WP_010481882.1|2852775_2853987_-|methionine-adenosyltransferase
MSSYLFTSESVSEGHPDKVADQISDAVLDAILTQDQRARVACETMVKTGVAIVAGEITTSAWIDLEALTRKVITDIGYDSSDVGFDGATCGVLNLIGKQSPHIAQGVDRKKPEEMGAGDQGLMFGYATNETDSYMPAAIHLSHRLVEQQAKIRKKKNSPLSWLRPDAKSQVTLRYENGVVSAIDAVVLSTQHAPGIKQKDLIEAVREEIIKPVLPAKWLHKGTKFHINPTGKFEIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKISDDKIEKLIRKHFDLRPYGIIKMLDLVHPMYQQTAAYGHFGRKPKEFSYLNGEGETVNATAFSWEKTDRAAALRADAKLK
>NZ_CP037858.1|WP_142807270.1|2866929_2868228_-|NupC/NupG-family-nucleoside-CNT-transporter
MVEGLGRIGFGLFGLAVLIDITWLFSNNKRAVDWKLVATGITLQIAFAALVILVPGGRDVFDALGHGFVKVLSFVNEGSGFIFGSLMDTKNYGFIFAFQVLPTIIFFSALMGVMYHLNIMQAIVRVMAWAITKVMRVSGAETTSVCASVFIGQTEAPLTVRPYIAKMTQSELLTMMIGGMAHIAGGVLAAYVGMLGGGDPAQQAFYAKHLLAASIMAAPATLVVAKLLIPETGTPLTRGTVKMEVEKTSSNIIDAAAAGAGDGLKLALNIGAMLLAFIALIALLNAPLTWIGEVTGLAAQIGKPTNLSTIFGYLLAPIAWVIGTPWADATTVGSLIGQKVVINEFVAYTELSQIVNGQVAGVSLSSEGRLIATYALCGFANFSSIAIQIGGIGGLAPERRHDLAKFGLRAVLGGTIATFMTATIAGVLTHFS
>NZ_CP037858.1|WP_099553706.1|2868421_2869393_+|aldo/keto-reductase
MQYRRLGSTGLPVSALSFGAWVTFGDQIPRDEARNLVAAAWDHGVNFFDNAEGYANGRAEQVMGDVISDLRLPRDGFCVSSKVFFGSAKDPRPTQRGLSRKHVTDACHAALKRLRVDYLDLYYCHRPDPDAPIAETVHAMDTLVRQGKILYWGTSEWSAIQIQQALDFAERHNLQGPSMEQPQYNLLHRERVEVEYAPLYARAGLGTTIFSPLASGLLTGKYDQGIPADARLGREGMEWLQDLVLGADAEARLGQVRRFSEVARALGQAPATLAIAWCLRNPNVSSVILGASRVSQLLQNLQALEVLEQVDAAGWAEVEAVFG
>NZ_CP037858.1|WP_005412278.1|2869653_2869848_+|hemin-uptake-protein-HemP
MNAQPVLLRPETLTLRDRPVRVVPPEEVIDSEALLKGRREILIQHGDRFYRLRHTSNDKLILTK
>NZ_CP037858.1|WP_142808103.1|2870037_2872245_+|TonB-dependent-hemoglobin/transferrin/lactoferrin-family-receptor
MALPLSAHAAATAAPDAREFDRVQVTATRTERAVSDVAATVDVIDREQMDRHLVQDIKDLVRYEPGLSVTRSATRFGLDGFRIRGLDGNRVRIQTDGIVMPTRFDIGSFASSNRNFTDLDTLKRVEIVRGPASSLYGSDALGGVVAFVTKDPADYLKDGKNSYFGLKFGYDGEWKGLLGGATAAFGGDHWSGLVNVNHHQGQETDNKGTVRSDNDTRTASNPQDRDGRSLLSKLVYAPSEDQRFRLTVEGNEDTTDTNVLSAIASVAPRPGAMAAATGMKSHDTQKRNRVSFAHEMDALDQSFADSLHWQVYAQNSETRQQTDETRTDGTSRHRVFSFDQHAYGLQAQFNKAFTTGSVEHALTYGFEGTRTEIRQKRDGYQVSKAGVVSNTVVPDTFPVRDFPISKTTELGLYAQDEMRFADGRLSLVPGVRVDRYELKPEVDGIFAEDNPTTAVAQLKKTSVSPKLGMVWRFTDEWSLFAGYARGFRSPPYNDVNIGLTNVAFRYTAIANPDLKPETSDGYELGLRFIAPAAYVSVSGYYNDYKDFIQSNVDTGRNAQGLTVFQSQNIADARIYGAEMKAGIEFGELSPALKGWALRSALAWSRGDNRTDDEPLASVDPLRGTLGLMYDTDTWGVELAGTFVQRKKRLPPPAAQTNPNAPAPFVYQPAGYGVLDLMAHWNFAPGATFNVGVFNLVDKRYIEWSSITPSLITNRALSDRFSSPGRTFSASLAVSW
>NZ_CP037858.1|WP_099553672.1|2872249_2872849_+|Hemin-transport-protein
MSRALSARRNDSIAAPHSAAWPTPAQLATLGTVLCLYHADGNELGGWRQAVRVHACQGVDSEGLRESLCFLDGRGRCVWRLYLLPDSDFLAWDRLVAALPPGPEHDSEASVGERLWRRLAGHLGGQRWRLCALRLHAADDGRTLAASLSTLSSLGAATARRIARLEGAEGELAIDDCCCADAARRPAPRIPGDLPLIRL
>NZ_CP037858.1|WP_142807271.1|2872922_2873849_+|hypothetical-protein
MKLQTASAMLLLAASGVASAQPSDIARDHDSILAMQGEYTVDFAFDETVLLKPGYERAPAMRSGGSEVVIVVEDTPKRIVLQHLLLDEKSGHITKHWRQDWVYEAPNRFEFSADQTWNVRSIPAAVSQGAWTQCVYEVSDAPRYCGTGAWTYTNNVPSWTSDLSWRPLPRREYTKRSDYNALAVINRHTLTPNGWTHEQFNTKVQRNADGSQVEIAREFGFNDYVKTTEVDFTPARNYWKATAGYWAKVRQRWDGFLTQAPGVHLKTKIDGMAMIIPLFTQAEEIQSGKKVKDKQIDEVFAKYVEKAQ
>NZ_CP037858.1|WP_142807272.1|2873877_2874363_-|hypothetical-protein
MNYGFCLRVLLAGVPLLVAMPAVSARTAPGLVPDPVQAFILETVLADEVRAFHDGHPTYLVPASVSRTRTDAEVMADLRAEFNQFYQGQPKPRKEVAHMAILVSQTALLLPDRSACSTDQVRCHEAVMGVRTRDDEASLQVTLQAFQDAGLDLTTLGGPTS
>NZ_CP037858.1|WP_049444405.1|2874365_2874719_-|DMT-family-protein
MPGTSFAAYLYPVLLLLGSNIFMTFAWYGHLKYKSAPLMMVILVSWGIAFFEYCLQVPGNRLGSAVYSAPQLKGMQEVITLLVFAVFSAFYLGQPLKWNHYAAFGLIVVAAFLMFKE
>NZ_CP037858.1|WP_142807273.1|2874787_2877301_-|FtsX-like-permease-family-protein
MNLLRHAWRALRREALAGDLLTVFAALVLGVAVMTAVGTLVNRVNLALTGSAAEMLGGDLGIAGRDDPPQAFADEAQRRGLAFTRIASFGSVLFNGDASQMASIKAVQAGYPLRGTLRVRSTPGGALIANAGMPPKGQAYADPRLLQGLGLKAGDDLEFGAGTLRIAGIIEAEPDTGGDLLTPSPTLLVNRADVEGTGLLGPGSRINYRLMFAGPAGQVASLREWLLPQVKGLRLLNVDDTQRGVRQAFDLAGRFLGLSALLAVLLAGVATALAANRFALRRIDQVAILRCLGARQRDILLGLALQLLMLAVPACALGIGLGMAAQEGLVQVLGSLVPQRLPLPEAMPALTGAGIGLLLLFGFGLPPLLRLRGVPPMRVLNRSFAALPPASLLAYVAALGASLLLAVQVTGDLKLALWVLGGLAALAVAAGVVGFVLLQLMRGLQHRLHGNWRLGLAALTRRRLLAVMQLVGLSLSLCALLLLAVTGPGLLQQWRERLPADTPNYFLINIQPEQRDSVLATLRGLGANDASIEPMATGRLIAINGKPPLRVDREPGQDGQPTQGGQRDDDDENRPLNFSWRSSFPPANTLMNGTFWTPDSTAAEASVEIGWAKRYGVYPGDRITIAVGEQEREFTVTSVRKADWNTFRPNFFVLLNPNAVGDTPHNLLSAFHLPAGKAAGLGELVRAQPNLSLLDVDAVISQVRDVMERVAQAVQLVMVFSLLAGVLVLLAALQATAGERRYDSAVLCTLGATRRQLRGAVLVEFGALGMLAAMLAVGAAAAIGVAVSQKVFELPLLPPWPGLLIGGVVGIGLSLLAGWWGTRAILHTPPALALREA
>NZ_CP037858.1|WP_142807274.1|2877297_2877945_-|ATP-binding-cassette-domain-containing-protein
MQGPEGEVHILDNITLTVHEGTSVAIVGASGSGKTTLLGLLAGLDLPSRGHIALVGQDLGHLDEEARAQLRAHEVGFVFQSFHLLPALTAAENVALPLELAGREDRARVDEVLAQVGLSHRARHYPRQLSGGEQQRVALARAFVTRPRILFADEPTGSLDHATGQHISDLLFELNAGSGTTLVLVTHDLRLAQRCQYIHRIDDGRLLPVEHGAQA

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Crispr_ID: NZ_CP037858_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP037858_8

4020689-4020796

Orphan

Consensus_repeat	Method
GGTAGGCGTCGACCGTGGTCGACGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP037858_8

>merge|NZ_CP037858|8|4020689-4020796|CRISPRCasFinder
GGTAGGCGTCGACCGTGGTCGACGAACGGGATGTCAGCCCTGGCGGACGTCGACCTTGGTCGACGAACGAGGTGCCAGCCCTGGTAGGCGTCGACCTTGGTCGACGAA

>NZ_CP037858|8|7|4020689-4020796|CRISPRCasFinder
GGTAGGCGTCGACCGTGGTCGACGAA	CGGGATGTCAGCCCTGGCGGACGTCGACCTTGGTCGACGAACGAGGTGCCAGCCCT
GGTAGGCGTCGACCTTGGTCGACGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP037858.1\|WP_142807820.1\|4015391_4016399_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|366736
NZ_CP037858.1\|WP_099552864.1\|4038895_4039255_-\|response-regulator	unknown	unknown	gnl\|CDD\|237425
NZ_CP037858.1\|WP_049398541.1\|4021680_4023213_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143448
NZ_CP037858.1\|WP_099552872.1\|4020327_4020612_-\|DUF4190-domain-containing-protein	unknown	unknown	gnl\|CDD\|379388
NZ_CP037858.1\|WP_142807819.1\|4014257_4015292_+\|DUF1624-domain-containing-protein	unknown	unknown	gnl\|CDD\|225193
NZ_CP037858.1\|WP_099552866.1\|4028037_4028604_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP037858.1\|WP_099552880.1\|4013101_4013527_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP037858.1\|WP_142807823.1\|4026195_4027089_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378964
NZ_CP037858.1\|WP_142807821.1\|4024291_4024744_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_099552876.1\|4016497_4017385_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP037858.1\|WP_099552871.1\|4020877_4021681_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_CP037858.1\|WP_142807818.1\|4013670_4014261_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP037858.1\|WP_142807824.1\|4027036_4027867_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_CP037858.1\|WP_142807822.1\|4025067_4025493_+\|aldehyde-activating-protein	unknown	unknown	gnl\|CDD\|368144
NZ_CP037858.1\|WP_099552873.1\|4019551_4020322_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP037858.1\|WP_099552875.1\|4017417_4018479_-\|UDP-N-acetylmuramate-dehydrogenase	unknown	unknown	gnl\|CDD\|234593
NZ_CP037858.1\|WP_142807817.1\|4012325_4013129_+\|APH(3')-II-family-aminoglycoside-O-phosphotransferase	unknown	unknown	gnl\|CDD\|270699
NZ_CP037858.1\|WP_142807825.1\|4035141_4038831_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP037858.1\|WP_099552874.1\|4018487_4019543_-\|quinone-dependent-dihydroorotate-dehydrogenase	unknown	unknown	gnl\|CDD\|235388
NZ_CP037858.1\|WP_142808127.1\|4025613_4026078_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701

Protein	Function_ID	Function_description	E-value
NZ_CP037858.1\|WP_142807820.1\|4015391_4016399_+\|phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	3.90824e-11
NZ_CP037858.1\|WP_099552864.1\|4038895_4039255_-\|response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	1.88602e-19
NZ_CP037858.1\|WP_049398541.1\|4021680_4023213_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143448	cd07130, ALDH_F7_AASADH, NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B. Alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as ALDH7A1, Antiquitin-1, ALDH7B, or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), is a NAD+-dependent ALDH. Human ALDH7A1 is involved in the pipecolic acid pathway of lysine catabolism, catalyzing the oxidation of alpha-aminoadipic semialdehyde to alpha-aminoadipate. Arabidopsis thaliana ALDH7B4 appears to be an osmotic-stress-inducible ALDH gene encoding a turgor-responsive or stress-inducible ALDH. The Streptomyces clavuligerus P6CDH appears to be involved in cephamycin biosynthesis, catalyzing the second stage of the two-step conversion of lysine to alpha-aminoadipic acid. The ALDH7A1 enzyme and others in this group have been observed as tetramers, yet the bacterial P6CDH enzyme has been reported as a monomer.	0
NZ_CP037858.1\|WP_099552872.1\|4020327_4020612_-\|DUF4190-domain-containing-protein	gnl\|CDD\|379388	pfam13828, DUF4190, Domain of unknown function (DUF4190). This integral membrane domain is functionally uncharacterized. One of the membrane helices contains two GXXG motifs that are usually associated with dimerization.	9.55959e-10
NZ_CP037858.1\|WP_142807819.1\|4014257_4015292_+\|DUF1624-domain-containing-protein	gnl\|CDD\|225193	COG2311, COG2311, Predicted membrane protein [Function unknown].	3.93156e-10
NZ_CP037858.1\|WP_099552880.1\|4013101_4013527_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	4.27562e-13
NZ_CP037858.1\|WP_142807823.1\|4026195_4027089_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378964	pfam12833, HTH_18, Helix-turn-helix domain.	9.80969e-15
NZ_CP037858.1\|WP_099552876.1\|4016497_4017385_-\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	5.72488e-16
NZ_CP037858.1\|WP_099552871.1\|4020877_4021681_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.40722e-60
NZ_CP037858.1\|WP_142807818.1\|4013670_4014261_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.8736e-13
NZ_CP037858.1\|WP_142807824.1\|4027036_4027867_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	1.95375e-13
NZ_CP037858.1\|WP_142807822.1\|4025067_4025493_+\|aldehyde-activating-protein	gnl\|CDD\|368144	pfam04828, GFA, Glutathione-dependent formaldehyde-activating enzyme. The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.	3.15652e-09
NZ_CP037858.1\|WP_099552873.1\|4019551_4020322_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.15173e-15
NZ_CP037858.1\|WP_099552875.1\|4017417_4018479_-\|UDP-N-acetylmuramate-dehydrogenase	gnl\|CDD\|234593	PRK00046, murB, UDP-N-acetylmuramate dehydrogenase.	0
NZ_CP037858.1\|WP_142807817.1\|4012325_4013129_+\|APH(3')-II-family-aminoglycoside-O-phosphotransferase	gnl\|CDD\|270699	cd05150, APH, Aminoglycoside 3'-phosphotransferase. APH catalyzes the transfer of the gamma-phosphoryl group from ATP to aminoglycoside antibiotics such as kanamycin, streptomycin, neomycin, and gentamicin, among others. The aminoglycoside antibiotics target the 30S ribosome and promote miscoding, leading to the production of defective proteins which insert into the bacterial membrane, resulting in membrane damage and the ultimate demise of the bacterium. Phosphorylation of the aminoglycoside antibiotics results in their inactivation, leading to bacterial antibiotic resistance. The APH gene is found on transposons and plasmids and is thought to have originated as a self-defense mechanism used by microorganisms that produce the antibiotics. The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	2.80208e-109
NZ_CP037858.1\|WP_099552874.1\|4018487_4019543_-\|quinone-dependent-dihydroorotate-dehydrogenase	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	0
NZ_CP037858.1\|WP_142808127.1\|4025613_4026078_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	1.53617e-15

>NZ_CP037858.1|WP_099552872.1|4020327_4020612_-|DUF4190-domain-containing-protein
MSVAPRQTSALAVVSLVMGIASWTVLPFVASIVAIVTGHMARAEIRRRPQELEGDGLAVTGLVLGWVMVGAAIAAILVFILFFGGLAWLAAMSN
>NZ_CP037858.1|WP_099552873.1|4019551_4020322_-|class-I-SAM-dependent-methyltransferase
MTTSDSTERFSSRVADYVRYRPDYPPALLEWLHGPMGVSHEAVVADIGAGTGISSRQFLATGHPVIAVEPNAAMRAASEQWLAPQYPQFSAIDGRAEATGLDEASVDLVSVAQAFHWFDTVAVRAEWQRILRPGGLALIYWNSRLLDASPFLVGYEQLLLDYGTDYTAVAERYQDDATMQAWFGAGLRGMVQLPNVQYLDLDALQGRLLSSSYAPQPGHPRHAPMIAALQDLFAAHAVDGQVAFEYRTRAFLGTLD
>NZ_CP037858.1|WP_099552874.1|4018487_4019543_-|quinone-dependent-dihydroorotate-dehydrogenase
MYSLARPFLFSLDAERAHGLGLSALDLAYRTGTTPLLAARIAPMPSTVFGLTFPNPVGLAAGLDKNGEHIDALFALGFGFVEIGTITPRPQAGNPQPRLFRLPEHNAIINRMGFNNAGVDALVRNVERARNRRGLLGINIGKNKDTPNEQAVDDYIACLDKVYPLADYITVNISSPNTAGLRELQEETALRQLVSQLRDRQEALAAQHGRRVPMLVKVAPDLSERDIDAAARVLGELQVDGVIATNTTIDHSKVAGDPLANEAGGLSGAPVLEQSTLVLRRLRSRLPESVPLIGVGGILSGADAVAKMAAGAALVQCYSGLIFRGPALVSECVEAIRRRREAPSRGAVAPL
>NZ_CP037858.1|WP_099552875.1|4017417_4018479_-|UDP-N-acetylmuramate-dehydrogenase
MDTVDGNAPLRWTLTRNAPLQALNTFHVQASAAQLLELHDPTLLPEVLALPEVASGPLLVLGSGSNVLIAEDLPGTVLVFGNRDISFLEHRADHAVIRAGAGVPWHGLVMWSLQEGLSGLENLALIPGTAGAAPIQNIGAYGAQVGEFIQAVEAWDCQEQAWVRLDNEQCGFAYRDSVFKQQMDRYLITAIELKLPLLHDLRMDYAGIREELQAQGVELPGAVDVANAVIAIRRRKLPDPDVLGNAGSFFKNPVLPLEQVDVLLQHFPELPVFPSDQDGKRKVSAAWMIESCGWKGFREGDAGVAPSHALVLVNHGNATGAALLALARRISASVLEKFGVPIEPEPRLLGAQW
>NZ_CP037858.1|WP_099552876.1|4016497_4017385_-|DMT-family-transporter
MRAALLMLGSTMAFGLMAVAIRYATRYVPTQEVAFFRNAFGLLALLPMLLRPGHAPLKTQQLPRYFVRSAIGLGSMLCAFWALGHLPLAQAVSLSYSTPLFVTIAAVLWLGETVRVRRWAAVVVGFIGVLVIVRPGTAGFTAGSLVAVAAAVLSSLVAIQIKQLTRVDSADTVVLYTYVFWVPLSLVPALFVWVWPTGMAWLWLLATGVLGTIGQLLWTRALRLGEVSALTPISFLQLPLVTLCGWLLFNETVDRWTIIGAGIILAANAYIAHREAVLSRRAASAAASAAAKPAE
>NZ_CP037858.1|WP_142807820.1|4015391_4016399_+|phosphotransferase
MSFASAQHLGEVLQQSYGITATAVVPRPVGADANASVYRVDARHGQWWLKCRTYQVDPAVWDSLHWLRGTLGIDEIVAPWPALTGGASVQRWGLQFTLFPYIEGQSGFEAALSHRQWRRLGEVLRRLHASPLPTELQRGLPTVRLETAALETVGQWLAGEGLAAAKDGLGRAFVSVWDRQHARITALHAQALQLRAALQEVPADLHLCHTDLHAGNLLMGNDGGLHLIDWDGLSLAPRERDLMFIGAAVGGRWGRENPLGFEDGYGSDRGDPRWIAWYRHWRILQDLIEFQQVLLGSDGEERSPPLRRQSLHYLGEQFAPGNVFDAAERAYRALG
>NZ_CP037858.1|WP_142807819.1|4014257_4015292_+|DUF1624-domain-containing-protein
MSAVDRRLHGLDLARYLALAGMVLVNFRLAMAVPAEGEGWLAGFFHLLEGKASATFVTLAGLGLVLATQRQGWWLASVQTWRRALFLLVLGLLNLTLFPADILHYYAVYFALAVVWLRASPRVLLASIVGLAACSFWALLHWDYSQGWNWQTLEYAGLWQWPGAVRNLLFNGFHPLLPWLCFFLLGMLLARLELSQPRVQRALLVLGVLLVGAGQGVQQLAQGTPWQAWLGTQPMPPGPAYVLTGAGAACSVIAACLWLARVRPGDWLAPFTAAGRMTLTLYVGHILLGMGTLESLGLLDGRASLASVLLWALLFLMLATGAAWLWSWQFARGPLEAMMRRIAG
>NZ_CP037858.1|WP_142807818.1|4013670_4014261_+|TetR-family-transcriptional-regulator
MNRADRNEQRIAQILQAALQCFLAKGFHQTSMRDIAQAAGVSLGNLYNHFPGKEAIILAVAVAESEELAPLLQRLAASDGERAQVLVFLQDFHALCRQPEWATLAVEVLAESARNPAVAEAFAANRRQLQATLAEALQHVAQRERRRPALTPALQSQVLLDAIESDALRRGLGEADGTDEASLDLGLLALLLGARA
>NZ_CP037858.1|WP_099552880.1|4013101_4013527_-|DoxX-family-protein
MPRMITTLLDSRVLWLLARLLLAVVFLSSGLAKLLAWDNSVAEMQAAGLQPPVLFNLASAVVLLGGSLCLLLDRLLWLGSGALAVFMLLTIVIVHTFWTKHGAEQQLALFFALEHLSVVGGLICAAIASHARAQKNSSSNR
>NZ_CP037858.1|WP_142807817.1|4012325_4013129_+|APH(3')-II-family-aminoglycoside-O-phosphotransferase
MEAPDPSTDGMPLPWAWQETLADARIERQSIGVSRADVARVQRPGQADAFVKSEVIDAFSELGDEIARLRWLQAQGQPAPTVIATAEEAGRRWLLMSALPGRDLASSPELAPQELVELLADALRGLHALPVAACPFDQRLASRLQAAQARVEAGMVDADDFDDERLGQSPQQVFAELCSTRPDHEDLVVSHGDACLPNLMVVEGRFSGFIDCGRLGVADRYQDLALAARSLVHNFGDTRWVAPLFQRYGAVADERRLAFYRLLDEFF
>NZ_CP037858.1|WP_099552871.1|4020877_4021681_-|SDR-family-oxidoreductase
MANDAETSVGRIPAGAPTLDFSGRRVLIAGGSKGIGREMALAFAGAGAQVSVCARGQAGLDALRADAQAQGTPLHTVSADLADAGQIQAWLQAAADALGGIDVLVNNATGYGMADDEDGWAASLQIDLMAAVRASRLALPWLRASSDACILNLSSIASQQPRPGGAPYAAAKAALSHYTTSQALALAKDRIRVNAIAPGSIEFDDGLWDRRRTEDPTLYHGTLAKIPFGRFGHPREIADAALFLCSPLARWVTGSVLNVDGGQVLMG
>NZ_CP037858.1|WP_049398541.1|4021680_4023213_-|aldehyde-dehydrogenase-family-protein
MSSELLKSLGLDAINAGTYLGNGEWSSATSGELITPVNPTTGEPIAQVRATTEAEYETVVARAQEAFKVWRTTPAPRRGEAVRLCGEALRKHKDALGSLVALEMGKSKPEGDGEVQEMIDIADFAVGQSRMLYGYTMHSERPGHRMYEQYHPLGLVGIISAFNFPVAVWSWNSFLAAICGDVCIWKPSNKTPLTAIASLKICNDALREAGFPDIFFLINDAGTALSEKMVDDRRVPLISFTGSTQVGRTVNEKVARRLGRCLLELGGNNAIILDETADLKLAVPGIVFGAVGTAGQRCTTTRRLIVHRSIYADVLATLVKAYKQVEGKIGDPTDAANLMGPLNSDGAVQQFLDAIAQAKAAGGTIETGGTRIDRAGNFVLPAIVSGLKNSDAVVQHETFAPILYVMPYDSIDEAIDMQNGVPQGLSSSIFTQNLKTAEKFLSAAGSDCGIANINIGTSGAEIGGAFGGEKDTGGGRESGSDAWKVYMRRQTNTINYSDSLPLAQGIKFDL
>NZ_CP037858.1|WP_142807821.1|4024291_4024744_+|hypothetical-protein
MDDASDVEKALPAVLAECKKLILGMENKSVDQRKASLWVYGIGLVAGTVIAPALTAANAAKHAGAIAGLSALGGASGMAGKALEDSGFGGSAAIADRKAIADVIRLKLPVITDRREASHDRRKALTEMQAACFAYDLTTPKPIQSATTGK
>NZ_CP037858.1|WP_142807822.1|4025067_4025493_+|aldehyde-activating-protein
MSIRVACLCGNVAIELAGEPVARANCHCSSCRDFYGVTMFSATAWEASSVQMASFDARSFSHPQKQLKKTFCATCGEVVFGTNRLGMCVVPNAMLARADGGWLDVAMAPTMHLYYRQRVVEVRDELPKYLDGWDGPTYLQE
>NZ_CP037858.1|WP_142808127.1|4025613_4026078_+|GNAT-family-N-acetyltransferase
MPAQLQPVQPLHYPRIAGWLDSLAATQRWAGPGVAFPLLPEAFAQTLELAERPGWVLLDGEGACLGFGQYWLTAPGTAHLGRIIVSPQARGRGLGRVLVQLLGAEALRSPGVQRLTLRVYRDNVAAVALYRDLGFQPVEDASTPELLFMQRSGV
>NZ_CP037858.1|WP_142807823.1|4026195_4027089_+|helix-turn-helix-domain-containing-protein
MDRIPQLLEQDESMRLEVSTLAEGLGVPLSFGHAYLAVLVCVSGRARFALNFREVAVQRHDVLVLAEDTLALLRQRSRGFLAVVCLMPKALASEVAYVLPNALFKFLHEHPHCVPSPLEVPLLLGWLQQLMDAQHNGGRHRHVMLRNLLQTLFLKFATLLPEHSEAAPQVGRRERLAWNFWELVGQRSTRQRDVQSYAEALCITPFYLSQLTRECFDETPKALIDRQVVLEIKALLSYSELPIGRIAERLCFEDASYLCRYFRRHTGQSLTGYRRAGQGDASAIRTAAPELRPADPR
>NZ_CP037858.1|WP_142807824.1|4027036_4027867_-|universal-stress-protein
MLHPLRDIAVLFDASDTGDRVLSIAAHLAKAQQAHLVAVSTAQHPTDIANGFARGAGIAAALDHEARADAACTAQLMQNLRDAAEPLQISTELRIVSDYLGGADLALQSLYCDLIVAGYPRTPGAPSGWYPLGTLRQTGVPMLLVPPHWKGEQVGRRIVVAWNASKQARRAVADALPLLARAQAVHLLMVDTPKAEAAPGAEMAQHLARHGVEVEIQAISSSQGGVAATIRQHVLDAEADLLVLGPYSRSRVVERVLGGVTEDLLAEVPAPLFVSH
>NZ_CP037858.1|WP_099552866.1|4028037_4028604_+|TetR/AcrR-family-transcriptional-regulator
MRPATARTRRDLHHALAATLVSHPRCTLSELARGAGISRATLYRFAPTREAIDEALFAAGFERLEAAASSFDGNVDAQQVLEQVTAALLADWELVTLVFARMMEEQQRQGDLHLLPERWAPIGERFEAFFLRGQRVGEFNVEFTAVWLADFYWTCFYGITWSLARGRLAPAMAASTLLASFRHGAMKG
>NZ_CP037858.1|WP_142807825.1|4035141_4038831_+|hypothetical-protein
MSAHHSAARRAARLPRAALYQALLLGLAGAAQAAPPAAEPAPIRCDGTQCNAEGELLFSLRSRSYDEPVTEGTSSRSSSQALQPDRRVSLAIDEPGRATVRGEFMIRLPEGGAIWATEDPAMGQPELSVSAPGMVAFDEGRIVRPVEFYVRGNYTAFIQRLEVSVYRGSDTDRVAALATFELPVAAVAQGVWDGTLPASTPLRRGDRLVYVLRAFDAEGNVDETTAQSMQLVTPAEFERGNQQLRDALEDRRGTSVDANQAASLSLLQQVFDGNGLRQQNIPVHGSRVRLRGRDLPLGASLKINGDSYPLDQDRKFAAEYLMPIGHHAFDVRVERLDAPVIARTLEVDVSGQYLFGVGLADITVYQNKASGAGQDLARGERNDDVLSDGRLAFYLKAKTRGRYLLTAQADTQNRPLDELFTGFTTADPRDLFRSLDPDLYYPTYGDDSLTQRDVDSMGRFYLRMDWDKNQALWGNYNTGLTGTEYAQYVRSLYGAALSWRSRGANAWGDARSELRLFGSQAETAPGHSEFIGTGGSLYYLRHASILSGSDQVVLEIRDRTTGRVEQRVPMVRGADYEIDALQGRILLTRPLAQVSRENLRRISRDVPLDGYEQRLIVDYEWVPTGFDSDDITAGVRGKHWFGDHVAVGATYVDEQRSGQDYSLRGADLTLQAGRGTYLKIEHSRSEATSAPVFFSDNGGLSFSRLNPEGPREGEATAVEARVNLRELGWTQRDWSAGAWWRQVDGGYSVGRFDTGQRVREQGAELLGYVTDDFSLYARYSEARRGSESLIQAQATAEWRIGENDRLSAELRRVQEDRGVGGNVAGVLAAARYTHRIGTSLDVYGGGQLTVDDDHGRYADNDAVVAGGTWTFANLSTVGAEVSDGDRGTAAQVNAEYRLTPQHSFYGAFTQSTDRSEYDPLFSPNAQDGWTLGQRWRLSDQVNVFNESQFLKSGQESGLAHTFGMDFYPAVGWNAGFTLSNGKLDASSGQVDRKAVSLSGGRTAPGTEWQSKLEWRRDTGAERRTQWVSTNRLSHRLNDSWRIAARFNYADTDDAINPVAGARFIEGNLGFAYRPWDNDRWALFGRYSYLYDLSTMGQVNGVDYDQRTQILSLEGVYRIDQRWEVAAKAARREGEVRYGRGTGPWFDSATSFAAGQLRYDLYYQWHGLLEYRVLDVRDGGSRQGWLAGVDRDIGRNFRVGVGYNFTDFSDDLTKFDYTHRGWYLNLVGRY
>NZ_CP037858.1|WP_099552864.1|4038895_4039255_-|response-regulator
MTDDPIRVLMVEDQTDLREMIGLALRDLGIDVATTADAHEAAALLKGEARFDVVFSDVSMPNGMSGIELSEHVAREQPQARMILSSGYARSQLPPLPEQVEFLPKPYRLRQLVQLLKQE

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2689400 : 2696807

Enterobacteria_phage(42.86%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_142807199.1\|2689400_2690456_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	3.2e-79	46.5
WP_142807200.1\|2690470_2691358_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	3.1e-96	58.5
WP_142807201.1\|2691354_2691912_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	2.1e-45	50.6
WP_142807202.1\|2691908_2692802_+	dTDP-4-dehydrorhamnose reductase	A0A1D7XFA3	Escherichia_phage	5.3e-27	36.8
WP_142807203.1\|2692854_2694258_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	8.0e-46	29.2
WP_142807204.1\|2694269_2695616_-	phosphomannomutase	A0A127AWJ1	Bacillus_phage	2.2e-29	26.4
WP_099527084.1\|2695850_2696807_+	SDR family oxidoreductase	A0A2K9KZK0	Tupanvirus	5.2e-89	48.1

DBSCAN-SWA_2

3060632 : 3136648

Escherichia_phage(20.0%)

protease,plate,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_032129320.1\|3060632_3061922_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.2e-135	58.0
WP_099485204.1\|3062064_3064515_+	endopeptidase La	A0A0R6PGP8	Moraxella_phage	3.0e-221	52.1
WP_004146343.1\|3064732_3065005_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	7.7e-22	61.8
WP_142807346.1\|3065892_3067848_+	peptidylprolyl isomerase	NA	NA	NA	NA
WP_099551255.1\|3068031_3069231_-	lytic transglycosylase domain-containing protein	NA	NA	NA	NA
WP_099551254.1\|3069227_3069992_-	hydroxyacylglutathione hydrolase	NA	NA	NA	NA
WP_142807347.1\|3070003_3070648_+	hypothetical protein	NA	NA	NA	NA
WP_032129326.1\|3070661_3071114_+	ribonuclease HI	J9Q745	Salmonella_phage	7.7e-43	53.4
WP_099551252.1\|3071118_3071850_+	DNA polymerase III subunit epsilon	A2I2Z6	Vibrio_virus	1.3e-07	28.9
WP_005408277.1\|3071919_3072624_-	serine/threonine-protein phosphatase	NA	NA	NA	NA
WP_142807348.1\|3073282_3076297_-	autotransporter domain-containing protein	NA	NA	NA	NA
WP_049430220.1\|3076549_3076954_+	hypothetical protein	A0A1C9C5K8	Heterosigma_akashiwo_virus	1.0e-17	35.3
WP_142807349.1\|3077000_3078047_-	glycosyltransferase family 9 protein	NA	NA	NA	NA
WP_012479275.1\|3078067_3078817_+	3-deoxy-D-manno-octulosonic acid kinase	NA	NA	NA	NA
WP_099553812.1\|3078816_3079584_+	MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_142807350.1\|3079580_3079970_+	DUF4440 domain-containing protein	NA	NA	NA	NA
WP_099553816.1\|3080535_3080853_+	quaternary ammonium compound efflux SMR transporter SugE	NA	NA	NA	NA
WP_142807351.1\|3081212_3092084_+	transporter	NA	NA	NA	NA
WP_142807352.1\|3092141_3092585_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_142807353.1\|3092660_3093770_-	DUF3667 domain-containing protein	NA	NA	NA	NA
WP_142807354.1\|3095156_3097187_+	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	2.1e-47	41.4
WP_004154630.1\|3097193_3097514_+	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_142807355.1\|3097596_3098196_+	recombination protein RecR	NA	NA	NA	NA
WP_014646179.1\|3098262_3098622_+	histidine triad nucleotide-binding protein	NA	NA	NA	NA
WP_008265847.1\|3098721_3099249_-	membrane protein	NA	NA	NA	NA
WP_142807356.1\|3099245_3101195_-	DUF3488 domain-containing protein	NA	NA	NA	NA
WP_142807357.1\|3101187_3102132_-	DUF58 domain-containing protein	NA	NA	NA	NA
WP_142807358.1\|3102134_3103088_-	AAA domain-containing protein	NA	NA	NA	NA
WP_142807359.1\|3103130_3104966_+	glycosyltransferase family 39 protein	NA	NA	NA	NA
WP_142807360.1\|3105063_3105633_-	septum formation inhibitor Maf	NA	NA	NA	NA
WP_012479287.1\|3105746_3106256_+	hypothetical protein	NA	NA	NA	NA
WP_004154640.1\|3106363_3106558_+	50S ribosomal protein L32	NA	NA	NA	NA
WP_099553840.1\|3106649_3107627_+	ketoacyl-ACP synthase III	NA	NA	NA	NA
WP_099553842.1\|3107705_3108488_+	serine/threonine protein phosphatase	NA	NA	NA	NA
WP_099553844.1\|3108648_3109593_+	ACP S-malonyltransferase	NA	NA	NA	NA
WP_005408312.1\|3109675_3110419_+	3-oxoacyl-ACP reductase FabG	Q06VL0	Trichoplusia_ni_ascovirus	4.7e-13	32.3
WP_005408313.1\|3110571_3110811_+	acyl carrier protein	B2ZXV3	Ralstonia_phage	4.6e-10	44.6
WP_142807361.1\|3110953_3112216_+	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_142807362.1\|3112328_3113693_+	aminodeoxychorismate synthase component I	NA	NA	NA	NA
WP_142807363.1\|3113908_3114970_+	endolytic transglycosylase MltG	NA	NA	NA	NA
WP_043033676.1\|3114966_3115632_+	dTMP kinase	W8D0J5	Erwinia_phage	9.4e-21	34.9
WP_142807364.1\|3115628_3116585_+	DNA polymerase III subunit delta'	NA	NA	NA	NA
WP_004146965.1\|3116581_3116935_+	pilus assembly protein PilZ	NA	NA	NA	NA
WP_142807365.1\|3117390_3117771_+	tautomerase family protein	NA	NA	NA	NA
WP_099497689.1\|3117851_3118925_-	phage late control D family protein	D5LGY1	Escherichia_phage	1.1e-92	51.0
WP_049430174.1\|3118915_3119131_-\|tail	tail protein	NA	NA	NA	NA
WP_049430173.1\|3119114_3119582_-\|tail	phage tail protein	A4PE53	Ralstonia_virus	2.2e-08	29.6
WP_142807366.1\|3119584_3122032_-\|tail	phage tail tape measure protein	A0A1W6JT50	Escherichia_phage	2.8e-30	22.4
WP_005412456.1\|3122152_3122443_-\|tail	phage tail assembly protein	A0A193GYZ8	Enterobacter_phage	1.5e-18	58.5
WP_099553864.1\|3122523_3123027_-\|tail	phage major tail tube protein	A0A193GYM4	Enterobacter_phage	6.8e-40	50.6
WP_142807367.1\|3123029_3124232_-\|tail	phage tail protein	A0A088FVH5	Escherichia_phage	4.6e-127	54.0
WP_142807368.1\|3124338_3124998_-	hypothetical protein	V9IQM3	Stenotrophomonas_phage	2.0e-15	31.0
WP_142807369.1\|3124999_3126967_-\|tail	tail fiber domain-containing protein	V9IQX0	Stenotrophomonas_phage	3.1e-112	41.0
WP_142807370.1\|3126974_3127754_-\|tail	phage tail protein I	V9IQK7	Stenotrophomonas_phage	2.1e-43	50.0
WP_142807371.1\|3127746_3128643_-\|plate	baseplate assembly protein	V5YTH6	Pseudomonas_phage	3.2e-80	56.1
WP_005408332.1\|3128645_3128984_-\|plate	phage baseplate protein	A0A193GYY8	Enterobacter_phage	7.8e-32	62.2
WP_142807372.1\|3129036_3129627_-\|plate	phage baseplate assembly protein V	A0A193GYL5	Enterobacter_phage	8.6e-26	38.7
WP_142807374.1\|3129623_3130178_-	hypothetical protein	NA	NA	NA	NA
WP_142807375.1\|3130530_3130908_-	hypothetical protein	NA	NA	NA	NA
WP_099553884.1\|3130904_3131390_-	glycoside hydrolase family 104 protein	D5LH07	Escherichia_phage	1.7e-43	56.9
WP_043033662.1\|3131386_3131737_-	hypothetical protein	NA	NA	NA	NA
WP_142807376.1\|3131733_3132183_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_049444117.1\|3132517_3132901_-	hypothetical protein	NA	NA	NA	NA
WP_142807378.1\|3133053_3133692_-	hypothetical protein	A0A2H4J8A1	uncultured_Caudovirales_phage	2.4e-21	38.6
WP_142807379.1\|3133733_3133961_-	hypothetical protein	NA	NA	NA	NA
WP_142807380.1\|3134035_3134311_-	hypothetical protein	NA	NA	NA	NA
WP_142807381.1\|3134311_3136648_-	toprim domain-containing protein	D5LH15	Escherichia_phage	1.1e-135	42.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP037858

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection