CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP038157	Corynebacterium sanguinis strain CCUG 58655 chromosome, complete genome	9 crisprs	DEDDh,csa3,DinG,WYL	2	6	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP038157_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_1

142627-142779

Orphan

Consensus_repeat	Method
TGTCAACAATGTCGCGACTGACCTGACAACCATCA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP038157_1

>merge|NZ_CP038157|1|142627-142779|CRISPRCasFinder
TGTCAACAATGTCGCGGCTGATCAGCTTGACGGCCGCCGAAACGCGCCCCGGCACCAGTGTCAACAATGTCGCGACTGACCTGACAACCATCATCCCAGGTGGTTTTGCGACCCTAACTGTCAACGATGTCGCGACTGACCTGACAACCATCA

>NZ_CP038157|1|1|142627-142779|CRISPRCasFinder
TGTCAACAATGTCGCGGCTGATCAGCTTGACGGCC	GCCGAAACGCGCCCCGGCACCAG
TGTCAACAATGTCGCGACTGACCTGACAACCATCA	TCCCAGGTGGTTTTGCGACCCTAAC
TGTCAACGATGTCGCGACTGACCTGACAACCATCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_144317254.1\|145571_146834_+\|restriction-endonuclease-subunit-S	unknown	unknown	gnl\|CDD\|341202
NZ_CP038157.1\|WP_144317258.1\|151641_152127_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317245.1\|132050_133442_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP038157.1\|WP_136648868.1\|141436_142624_-\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP038157.1\|WP_144317244.1\|131162_131972_-\|Fpg/Nei-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
NZ_CP038157.1\|WP_144317251.1\|140410_140926_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317248.1\|138875_139676_+\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|376313
NZ_CP038157.1\|WP_144317261.1\|155103_155385_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317247.1\|138066_138852_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl\|CDD\|238816
NZ_CP038157.1\|WP_144317253.1\|143610_145575_+\|N-6-DNA-methylase	unknown	unknown	gnl\|CDD\|223363
NZ_CP038157.1\|WP_144317257.1\|150481_151642_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317252.1\|140931_141162_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317262.1\|155387_156758_+\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|222853
NZ_CP038157.1\|WP_144317259.1\|152277_152607_-\|transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP038157.1\|WP_144317246.1\|133438_138034_-\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|137505
NZ_CP038157.1\|WP_144317260.1\|152587_154006_-\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP038157.1\|WP_144317255.1\|146830_150022_+\|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl\|CDD\|223683
NZ_CP038157.1\|WP_144317250.1\|140156_140414_+\|mycoredoxin	unknown	unknown	gnl\|CDD\|131255
NZ_CP038157.1\|WP_144317249.1\|139675_140155_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|238127
NZ_CP038157.1\|WP_144317256.1\|150194_150374_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_144317254.1\|145571_146834_+\|restriction-endonuclease-subunit-S	gnl\|CDD\|341202	cd17521, RMtype1_S_Sau13435ORF2165P_TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD2-CR2, Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) TRD1-CR1 and Pseudoalteromonas species P1-13-1a S. subunit (S.Psp1bORF2093P) TRD2-CR2. Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) recognizes 5'... TCTANNNNNNRTTC ... 3', and the recognition sequences of Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) and Pseudoalteromonas species P1-13-1a S subunit (S.Psp1bORF2093P) are undetermined. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD1 recognizes TCTA/TAGA, and -TRD2 recognizes GAAY/RTTC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. In addition, this family includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P.	6.11206e-50
NZ_CP038157.1\|WP_144317248.1\|138875_139676_+\|thymidylate-synthase	gnl\|CDD\|376313	pfam00303, Thymidylat_synt, Thymidylate synthase. This is a family of proteins that are flavin-dependent thymidylate synthases.	0
NZ_CP038157.1\|WP_144317245.1\|132050_133442_+\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	2.66508e-13
NZ_CP038157.1\|WP_136648868.1\|141436_142624_-\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.0567e-26
NZ_CP038157.1\|WP_144317244.1\|131162_131972_-\|Fpg/Nei-family-DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	3.94634e-63
NZ_CP038157.1\|WP_144317255.1\|146830_150022_+\|DEAD/DEAH-box-helicase-family-protein	gnl\|CDD\|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	8.51622e-74
NZ_CP038157.1\|WP_144317247.1\|138066_138852_+\|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl\|CDD\|238816	cd01638, CysQ, CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine biosynthesis (a principal route of sulfur assimilation).	6.90385e-69
NZ_CP038157.1\|WP_144317253.1\|143610_145575_+\|N-6-DNA-methylase	gnl\|CDD\|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.27437e-74
NZ_CP038157.1\|WP_144317259.1\|152277_152607_-\|transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	5.81844e-24
NZ_CP038157.1\|WP_144317262.1\|155387_156758_+\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.34365e-41
NZ_CP038157.1\|WP_144317246.1\|133438_138034_-\|ATP-dependent-helicase	gnl\|CDD\|137505	PRK09751, PRK09751, putative ATP-dependent helicase Lhr; Provisional.	0
NZ_CP038157.1\|WP_144317260.1\|152587_154006_-\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	2.20181e-94
NZ_CP038157.1\|WP_144317250.1\|140156_140414_+\|mycoredoxin	gnl\|CDD\|131255	TIGR02200, conserved_hypothetical_protein, Glutaredoxin-like protein. This family of glutaredoxin-like proteins is limited to the Actinobacteria and contains the conserved CxxC motif.	3.13147e-26
NZ_CP038157.1\|WP_144317249.1\|139675_140155_+\|dihydrofolate-reductase	gnl\|CDD\|238127	cd00209, DHFR, Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-methylenetetrahydrofolate which is then utilized by thymidylate synthase. Inhibition of DHFR interrupts thymidilate synthesis and DNA replication, inhibitors of DHFR (such as Methotrexate) are used in cancer chemotherapy. 5,6,7,8-tetrahydrofolate also is involved in glycine, serine, and threonine metabolism and aminoacyl-tRNA biosynthesis.	5.25656e-52

>NZ_CP038157.1|WP_136648868.1|141436_142624_-|IS481-family-transposase
MNSPNRNLAIVKAVREQHEPVAKVAARFNISRQRVYKILADFDTGGPDAIAPKSRAPRTHQHAVPEPLRNHIIEIRKELTRAGFDAGPDTIAFHLERQGMRVPSPSTIRRIITAAGLVTPQPQKKPRSSYIRFEAAMPNECWQADITHLFLLDGTRVEVLDFIDDHSRYLLSMTTRAAFTGVAVADELSRLIDIYGPPASTLTDNGLVFTARLAGRKGGRNAFEKVLTTHRIQQKNGRPGHPQTQGKIERFHQTLKKWISAQPPAETITQLQHQLDEFAGYYNTQRPHRALGRRTPETAYTTGPKATPTTTPTQEWRVRHDIVAPNGKVSIRYAGRLYHLGIGRAWAGENILMVITDNHITTSTQETSEIIAEHYIDTTRQYQKPYWRKGDPPLS
>NZ_CP038157.1|WP_144317252.1|140931_141162_-|hypothetical-protein
MTTEPKIKRSRQLLLLAFIAVVILAFIGIFVSVAIPLAVVYFAVVTALFYAIFKWLDHLIKRRSFHAEPWRPADEQ
>NZ_CP038157.1|WP_144317251.1|140410_140926_-|hypothetical-protein
MQDNDARLAVDITELATRIDAPTTDVPDSLKDADRFARIARVATELEVQALLAAHNDGVSWSRIGKHLGVSRQAVQQRVDPNYRPAPELPPTSRMLGPVDRNDEVEQLNAAGLQGWKPVKSEHGRHIMIKTDVKWEIQRVSIARLTAMPSAEAGWEAATTRFPDCFYVREI
>NZ_CP038157.1|WP_144317250.1|140156_140414_+|mycoredoxin
MTSPVTVYATSWCPYCRVLLAGLKRTDVDYEVVDVDDPKNAEFSDWVASVNNGNRIVPTVRFSDGTHATNPAVDVVAAKYRELTS
>NZ_CP038157.1|WP_144317249.1|139675_140155_+|dihydrofolate-reductase
MLGAIWAQSLDGVIGDGAGMPWHLPEDLKHFKEITFGHPIIMGRRTWEALPMRPLPGRPNHVVSSREAGTWSNGAFVSRDLPDLETDAWIIGGAQLYEATIDEVDIIERTLIDAHLAAAIGRNAVFAPRLTEDFKLVSDGGWLTSSTGLRYRFQRFERI
>NZ_CP038157.1|WP_144317248.1|138875_139676_+|thymidylate-synthase
MTVPAPYENLLRDILDNGSAKGDRTGTGTLSVFGRQLRYDLSSAFPLLTTKKVYFKGVVGELLWFLRGESNVTWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGSHIDQISESLRLLRDDPESRRNLVSAWNVSELDKMALMPCHLLFQLYVADGRLSMQVYQRSADMFLGVPFNIASYSLLTHMFAQQAGLKVGELIWTGGDCHIYNNHIEQVKEQLSREVRPYPTLELTKAPSLFEYDFDDIKVVGYDPHPTITAEVAV
>NZ_CP038157.1|WP_144317247.1|138066_138852_+|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MTVPDSQHSDSRLTNLIAQGTGEILKGIRGVGLLRGRELGEAGDDLAQNWIARVLAQHRPDDGFLSEEAADNSERLDKERVWIVDPLDGTKEFATGRQDWAVHVALVENGVPTHAAVGLPDLGVVFKSSDVRHVSGPLSRRIALSRNRPPEVAQFVADKLGFETVGVGSAGAKAMHVLLGDYDAYIHAGGQYEWDQAAPVGVSLAAGLHASRLDGSELRYNNADTYIPDLLICRPELAEDILKACAEYLEQHGSFDGLAGT
>NZ_CP038157.1|WP_144317246.1|133438_138034_-|ATP-dependent-helicase
MTASVLDRFHPQVATWFAEVFAAPTAVQEGAWRTISAGENALVVAPTGSGKTLAAFLWSLNSLVERAGQQALPIDGSTRSTHGGVKVLYISPLKALGVDVENNLRAPLGGIARVAQRMGLDTPDISVGVRSGDTPQAERNRQVRKPPDILITTPESLYLMLTSKAAGILKTVDTVIVDEIHALAGTKRGVHLALSLERLRRITGPFQRIGLSATVRPLEEVANFLGPKTTIVNPPAEKKWSLDVHVPVEDMSDLPVPEEASTIGEAIVDDLLDPAPVGASKSIWPHIERAVYDKVMAHRSTIVFVNSRRTAERLTSQLNELWAIEHDPDALSPALRRPPAQLMKAVDTAGHAPTLIARAHHGSVSKEERLTTETMLKEGTLKAVISTSSLELGIDMGAVDLVIQVESPPSVASGLQRVGRAGHSVGETSAGAFYPKHRSDLVQTAVTVPRMRAGQIEELRTPLSPLDVLTQQTIAAVSVEDLDVDEWYDTVRGAWPYRNLSRDVFDAVIDLVVGVYPSTDFAELRPRAILDGAVLKARPGAQRVAVTNAGTIPDRGMFGVFLVGGGEGSAPRRVGELDEEMVYESRVGDVFTLGASSWRIENITRDQVQVTPAPGHTGRLPFWTGDSLGRPYELGKALGEFRRQARSGPLDASLDEFARRNLIAYLDEQEEATGIIPDDTTLVLERFTDELGDWRVVLHTPFGKGVNAAWALAAGWRIAQDTGMDAQAVAGDDGIVLRLPQGEKEPDSSLFSFDADEIADIVTEQVGNSALFASRFRECAARALLLPRRNPGKRAPLWQQRQRAEQLLDVARNYPSFPIILETVRECLQDVYDLPALREVMQHLQTRRIRVAEVTTEQPSPFASSLLFNYTGAFMYEGGTPLAEKRAAALSLDPSLLAKLLGTVELRELLDADIIAEVDASLRRVGKAQTSEQFADTLRIAGPVAIDELSEYSSVPLASLESSLGARVMRVRIGGREHIAQVLDAPLLRDGLGVPVPPGVAAQVATINDALAQLVSRWVRTRGPFVLRELADAFGLAVGAAYSALAPLVDAGKVFEGRYRQGVSEQEYVAVEVLRIIRSRSLAAARAQTRPVSQSAFGRFLPSWSHVAPAGQVAALRGADGVYTVLEQLAGVRLPASAWESHVLPSRVGDYNPVMLDELTASGEISIVGAGKAGARDPWLMLLPADYAGQLMPDSVEPTLSLTQAQVLEKVRGGGGFLFTDLLQGTTVEELRESIWDLVEAGFVAPDSFAPIRARLSGGKTAHRAKRRPSRSRVRTGRTSFATVTPPDMVGRWAATPSVDTDATRRSVAFGEAWLDRYGVVTRGSVVAEDVLGGFALAYKVLSGFEESGKAMRGYLIEGLGASQFSTPATIDRLRGHQDSDDVVGWPSGTREPLMYVLAATDPANPYGAALPWPAQGPTRSAGAMVVLIDGLLAAHITRGGKTMTTFFDHFPEGIDDPMPLVISTLSQAVAAGRMKPLNVEKLNGEPAFSLRDFGAAVTHKGAKIGGSTSTPPKRRGRTVAEAMGELSFDD
>NZ_CP038157.1|WP_144317245.1|132050_133442_+|HNH-endonuclease
METTTPDNHRTAGAQLIIEGEYLVFSQYSEDHANSIDRDLDIEIAELMALTRRGKTFVESGIFGYSRLRDLPRLRALHATLKLLDVPRLAAIDKTLRVLPAHTAPETFALFDDALVSMFTRAGTTLPSLWSITRRLRRLIAEIDTSVNFDPKRRKKREESTAPNATFHPVSTGSGERSALTLTADTATMAAGGSFIRATAKEHKLGLADSIIKLLTGSLNPAPAPVLHIFTPGRDGARVPGSSAYLPGFGWTDADATAVPEDLLEFFPPTTTNLDDVRAKSVDRYSPTAEMADYARARDGTCIFPGCHTPADKCQLDHRIPFNGGGKTTPENLFCLCQHHHNVKTDRRAFYIPDPATGDTLWIFANRTWLTSESNGILAGQITPSSPRWRSTPASSHAARSRVARFNAQCHTLCDAYDVGGDYDACVNAIRVLEQESGLVFEFHPEPEDLSWIPPEPPYEEYG
>NZ_CP038157.1|WP_144317244.1|131162_131972_-|Fpg/Nei-family-DNA-glycosylase
MPEGDSVYQLSKRLQLMAGREVTHTSLRVPRFATVDFTGLTCDRVWPLGKHLFMQFGPETLHTHLKMEGTWSIHRAGTRWRKPGHTARVVLRLADAKGDIEIVGHELGLVDVFPTREYPTRMSYLGPDMLAEDFDHDEVVRRILRTPEMEIGRALLDQKNAAGIGNEYRAEICFLAGTHPARKVREVDVDKHVRLARRLMWANKDSPVRVTTGVKRAGETSYVFGRNNKPCRRCTTLIRKGFLGGAGDLERVIWWCPRCQPAAPSWHGG
>NZ_CP038157.1|WP_144317253.1|143610_145575_+|N-6-DNA-methylase
MFNHASFIWSAADLLRGTYKQHQYGNIILPFTVLARLDGVLAPTKQAVLAAIEGLDPEQTPSAGMLRNRAGHDYSFYNRSQHDLRSLQGDVDNLEENLRDYVNAFSPNVRDIFEQYKFDEIIIDLANNDLLLEILQHFAKADLRPEAVSNEVMGHIFEELIRKFAEASNETAGEHFTPREVIDLMVTILLDGDADLTTPGVIRSVYDPTAGTGGMLSAADNKIKDFNKHAQVNLLGQEINPESYAICKADMVAKGQPITNIQLGNTLTNPAFEDQTFHYALSNPPFGVAWKKDRPAVEREHKIAGYSGRFGPGLPRVSDGSLLFLMHLVSKLREPGLQGGAAGRGAIVLNGSPLFTGGAGSGESNIRKWVLDNDYLEAIIGLPTDMFYNTGISTYVWILNKDKDPARKGKVQLIDATEMSVKMRKSIGSKRKMLSGENIKTIAMLYGDFVESEHSKIFDTTDFYYRTITVERPLKLNYAFTSQRIDKVMTARPVARLEEGEQEALQAALRGAEAATGGVVSTNRAQFTTELKKALSAEEIVLKPAVLKAVITELGEHDDQGELVMKAGKPEADASLRDTENVPWDQDIHDYLEREVKPFVPDAWIDESKTKEGVEIPFTRHFCKYVPPRPLEEIDRDLDEVLGRIRLRLEQVKA
>NZ_CP038157.1|WP_144317254.1|145571_146834_+|restriction-endonuclease-subunit-S
MRKIPLKRLVSRPVVNGLGLSGSENNTDDPRYIRITDIGADGKLRDEVFASQPRQLIGDAWVHSGDILVASVGATVGKSYLHLSEGDFCYAGYLSRVRPDMSKAEPRFLGYWMESHDWWEQVRQRIVGSTIENLSASKIASFSVPLVSLEEQGLIADYLDRETAEIDAFLEDLKQLKAYTAERARALLEHELWATAKEFAPLRRFLLRVDQGISPEADSSPAGPGELGVLKAGCTNHGRFDLWANKRLDNSDQFTASMFVAEGDLIVTRASGSLMHVGSAALVPHLDRQLAMSDKHYRLVTDDHLDSEYLALVMQTARWRTQLEPLVSGAQGLARNISIPNLKTLEVPVVSRMQQEEVKEKLREQVQKVAMASDDVDALISLGEERRSALISAAVTGQIDVTAQGMSAAEQLQDELEAKV
>NZ_CP038157.1|WP_144317255.1|146830_150022_+|DEAD/DEAH-box-helicase-family-protein
MSVGAHREVHLQRFVVDHLTSHGWLSSKGNEGYDKERALFVPDLLGWLEETDPENYHRIVPKDGPEAAVTKGQKRILDRVAKQLGVEEKHGGGTLNVLRHGVDMVGAKKFSLLQMPPANDKNPRLTKRYERNRLRVVEELVYSTRHGNRLDLTLFANGIPVATAEIKTEFTQSLDQAKAQYRTQRLPQGEPLLTAGRGALVHFAVTDRRIAMTTFLNGQHTRFLPFDQSHEGGAGNPPSATGHATSYFWEEILDRDTWLTILTKFIYTNHQHKADPLTGKITTTSQIRFPRFHQWRAVSKIAKAAAVEGPGHNYLIQHSAGSGKTDSIAWTAHRLASLHNEAGEKVFDTVFVIADRQVLDRQLQDAVQQLETVAGTFQAIESGGSGSKTARLTEVLTSGTAKIVGVTLQTFPHALAALQDPDNQEKLAGRTFAVIADEAHSSQTGSSAKALREMLYLGKEAEEVDWEEPGADQDALAAMAARSDEDKRLSYFAFTATPKEKTLQLFGRRNPASQELEPFDLYPMKQAIEEGFILDVLKNYTTFEMAARVAEKGQDPSVAAEQQPGGLSAEAAINDGEVDVRQGTRAYINFVEHHPTNVASKVDVILDHYRSTVQPHLGGRAKAMIVTASRAAAVRYARALDKAITERNLPLQTLVAFSGEVPDPDVPSLPGTLQTMVTETSMNPVLNGRDLADVFAQDGQNILVVANKYQTGFDQPLLVGMYVDKQLSGIAAVQTLSRLNRKVDGKTDTYVLDFVNDAEQILASFQTYYEAAHIGTESDPDLVADLIAKLEAQRIFTWAEVDQVWEAWSAKRTPTARKHAQFSRHLLPAVERFENAWEQAIRTEDDQRREELLDFKAVLAQYVKAYSFFSQILHFGDPRYEKMSVFADLLAKALRNFTADAEKPEAVDVSDVVLTHYRLEKIREDDLGLSATDGEAPGLTGMTEAGLTKARESEQVRKSELIEKVNKYFGDLEAKDEYKVNFIETLLAEAADHPELEMQAKNNSKIDFASSPQLQVILEDALWQQEESSNEVLKSAREMTTLRLVEMAMEFGLFERLRGQDTG
>NZ_CP038157.1|WP_144317256.1|150194_150374_+|hypothetical-protein
MAVSPESLSAALSALGPAEEAVTAETVWAQSSKFFLSHWTSRWPETLPLPSVLDNPNTV
>NZ_CP038157.1|WP_144317257.1|150481_151642_+|hypothetical-protein
MTQADPNIETVASLHLDGDRFEDFGMPAATAQEIAALDELLYQLIELRWRAKHPDNSKLPNNFRQDYELRINTIAEGSATPLLERRRSIPDAPTLFPASSDEFTEDYRQAVAELEEILRVASEYGQLPESVYALPSPAIRNIGSTLREDEKLQVGHGRITDWSDKPAYTTFARKYLLEQLDKPQQKHVTYSGLVRSTNVSSGTFSFVDVESRVSATAAYDNGFELEIDGENEQTWAWVEVSGEVEFTINSNSHTFTSVDSINTSQLTPDYNRLQGRLNEIGDLQPGWLDGEIGDAFTKNQLDEAQAVLKASVVAGKLPDTVAPSIEGAIEFSWIDGNQHFSIEVEPEGSFYFHKSNTDSMNATSKDVESLSKYPSDLILEWVRRTV
>NZ_CP038157.1|WP_144317258.1|151641_152127_+|hypothetical-protein
MTQPNQLTEPDLVILRIINAQHFDNGIVTRAAFALSSNDNYKLSVNQESRITPGDALEQKSAILRARKESEGKPFTPPPAVARMTVGEIEDIPLPTEEGELQDGEQAALSVWDDSMLEGTPESHAYLDFERTYEPKERRKAVYNRLAAIANQNGKLFLPDH
>NZ_CP038157.1|WP_144317259.1|152277_152607_-|transposase
MLQPPVEPAQYTSLAFTDALADAGLQGSIGSVGDALDNAMMESTIGLYKTELIDVDPARTWRDAREVETETASWVYWYNHQRLHSSIGDVPPIEYEQDYEEFNTTRKAQ
>NZ_CP038157.1|WP_144317260.1|152587_154006_-|IS30-family-transposase
MKTSEGPEGMRRQWRADRALRPAMRSPGRPQPSRAVQRQFWRLIAAGVTTAEAALAVGVSVPVGSRWFRHAGGMPPLTLTEPTGRYLSFEEREEIAILRAQGRGVRSIARTLGRDPGTISRELRRNAATRSGKLEYRATVAQWKAQEAAKRPKTAKLVANLRLRDYVQDRLSGKVTGPDGTPVEGPVTPTWKGLNKPRRQDRRWATSWSPEQISHRLKLDFPDDESMRISHEAIYQALFIEGRGALKRELVACLRTGRALRQPRERSRNKPGGHVGAEVVISQRPAEAADRAVPGHWEGDLVIGTGRSAIGTLVERRSRATILVRLPRLDGWGEHPPVKNGPALGGYGAVAMNAALAAAITTLPQQLRKTITWDRGKELSGHAAFTLETGTKVFFADPHSPWQRPTNENTNGLLRQYFPKGTDLSRWSADDLEAVAHTLNNRPRKPLGWKTPAEVFGEALQSLKQAGVATTG
>NZ_CP038157.1|WP_144317261.1|155103_155385_+|hypothetical-protein
MYFERLEDGDISKAAARREISELLGVKESTLRNWIRKQEKQEQAPQPGSLSYEQLQAAYEEQAKEVAKLRRANEILKTASAFFAQAELDRKLR
>NZ_CP038157.1|WP_144317262.1|155387_156758_+|DDE-type-integrase/transposase/recombinase
MDFIRTYRNRFGVEPICETLTAHGIAIAPSTFYAHQSRGFGPTGAELDEAYAAHRIYRLWEENRKVYGRRKLWKAAIRDGMLIGRDQAERLMKITGIRGVSRGMHRKKTTVANPAHRRHPDRIGRRWRYPSHPDQWWIADFTYAWTRKGFCYVAFIVDAYSRQVLGWVVTTVMDTRMVLMALEHALFSRRRTRMDFTATGIVHHSDAGAQGGFNWSSQHLEVRKVFKDGDQGLEHEDQRGPGGDAAAVARGPGVAASNALSGQTAAIEGGAATILAPDRGRGHDSGGSAGGGGVGAGRITVVPSRWRYATADVDGANWSLSQFRGARGDRDLACSGTRCPVDRAYPWAGSGHDQSGVAPQRCYPQREAGVSRHGGPMESPRGRETTQDREAGGQPAASRLCPGQTLWEGHWPGRDAGGRAGHADVEGVEQASSARSTVGHQLEPGADQSPLEAGFP

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Crispr_ID: NZ_CP038157_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_2

881464-881595

Orphan

Consensus_repeat	Method
CCCCAGGTCAGATTCCGGGGCGAGCAACATCTGTCACAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP038157_2

>merge|NZ_CP038157|2|881464-881595|CRISPRCasFinder
CCCCAGGTCAGATTCCGGGGCGAGCAACATCTGTCACACTCGGAGGTGGCGTAGTGACAATAGTTGCAAAGATGGCGCATCATTGGGGAGTTTCCCCAGGTCAGATTCCGGGGCGAGCAACATCTGTCACAC

>NZ_CP038157|2|2|881464-881595|CRISPRCasFinder
CCCCAGGTCAGATTCCGGGGCGAGCAACATCTGTCACAC	TCGGAGGTGGCGTAGTGACAATAGTTGCAAAGATGGCGCATCATTGGGGAGTTT
CCCCAGGTCAGATTCCGGGGCGAGCAACATCTGTCACAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_144317673.1\|877975_878425_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317669.1\|872299_872905_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP038157.1\|WP_144317667.1\|870159_871392_+\|Bcr/CflA-family-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340878
NZ_CP038157.1\|WP_144317668.1\|871392_872289_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|238579
NZ_CP038157.1\|WP_144317675.1\|879956_881402_-\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	unknown	unknown	gnl\|CDD\|238576
NZ_CP038157.1\|WP_144317672.1\|875464_876124_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP038157.1\|WP_144318591.1\|876667_877786_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
NZ_CP038157.1\|WP_144317677.1\|884870_887078_+\|malate-synthase-G	unknown	unknown	gnl\|CDD\|235097
NZ_CP038157.1\|WP_144317682.1\|891220_891706_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317674.1\|879026_879965_+\|Ldh-family-oxidoreductase	unknown	unknown	gnl\|CDD\|224966
NZ_CP038157.1\|WP_006841268.1\|883138_884434_-\|isocitrate-lyase	unknown	unknown	gnl\|CDD\|237893
NZ_CP038157.1\|WP_144317670.1\|872907_874029_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP038157.1\|WP_144317678.1\|887206_888700_+\|DUF1846-family-protein	unknown	unknown	gnl\|CDD\|378092
NZ_CP038157.1\|WP_144317679.1\|888727_889423_+\|PIG-L-family-deacetylase	unknown	unknown	gnl\|CDD\|225031
NZ_CP038157.1\|WP_040423204.1\|882548_883043_-\|ribonuclease-E-activity-regulator-RraA	unknown	unknown	gnl\|CDD\|236487
NZ_CP038157.1\|WP_170228626.1\|891716_892388_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_CP038157.1\|WP_144317671.1\|874483_875464_+\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|223650
NZ_CP038157.1\|WP_144317676.1\|881743_882538_-\|Fpg/Nei-family-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
NZ_CP038157.1\|WP_144317681.1\|890336_891224_+\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|234663
NZ_CP038157.1\|WP_144317680.1\|889431_890307_+\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|181359

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_144317679.1\|888727_889423_+\|PIG-L-family-deacetylase	gnl\|CDD\|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	5.56234e-32
NZ_CP038157.1\|WP_144317669.1\|872299_872905_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.53057e-59
NZ_CP038157.1\|WP_144317667.1\|870159_871392_+\|Bcr/CflA-family-efflux-MFS-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.12126e-78
NZ_CP038157.1\|WP_144317668.1\|871392_872289_-\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	1.98266e-100
NZ_CP038157.1\|WP_144317675.1\|879956_881402_-\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	1.61236e-54
NZ_CP038157.1\|WP_144317672.1\|875464_876124_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	6.20404e-82
NZ_CP038157.1\|WP_144318591.1\|876667_877786_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	3.10122e-55
NZ_CP038157.1\|WP_144317677.1\|884870_887078_+\|malate-synthase-G	gnl\|CDD\|235097	PRK02999, PRK02999, malate synthase G; Provisional.	0
NZ_CP038157.1\|WP_144317674.1\|879026_879965_+\|Ldh-family-oxidoreductase	gnl\|CDD\|224966	COG2055, COG2055, Malate/L-lactate dehydrogenases [Energy production and conversion].	5.72535e-75
NZ_CP038157.1\|WP_006841268.1\|883138_884434_-\|isocitrate-lyase	gnl\|CDD\|237893	PRK15063, PRK15063, isocitrate lyase; Provisional.	0
NZ_CP038157.1\|WP_144317670.1\|872907_874029_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.80521e-38
NZ_CP038157.1\|WP_144317678.1\|887206_888700_+\|DUF1846-family-protein	gnl\|CDD\|378092	pfam08903, DUF1846, Domain of unknown function (DUF1846). This family of proteins are functionally uncharacterized. Some members of the family are annotated as ATP-dependent peptidases. However, we can find no support for this annotation.	0
NZ_CP038157.1\|WP_040423204.1\|882548_883043_-\|ribonuclease-E-activity-regulator-RraA	gnl\|CDD\|236487	PRK09372, PRK09372, ribonuclease E inhibitor RraA.	8.99792e-88
NZ_CP038157.1\|WP_170228626.1\|891716_892388_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	0.000717352
NZ_CP038157.1\|WP_144317671.1\|874483_875464_+\|FtsX-like-permease-family-protein	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	7.84707e-09
NZ_CP038157.1\|WP_144317676.1\|881743_882538_-\|Fpg/Nei-family-DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	3.39907e-62
NZ_CP038157.1\|WP_144317681.1\|890336_891224_+\|rhodanese-related-sulfurtransferase	gnl\|CDD\|234663	PRK00142, PRK00142, rhodanese-related sulfurtransferase.	8.12444e-142
NZ_CP038157.1\|WP_144317680.1\|889431_890307_+\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|181359	PRK08293, PRK08293, 3-hydroxyacyl-CoA dehydrogenase.	3.66767e-142

>NZ_CP038157.1|WP_144317675.1|879956_881402_-|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase
MSNLAYTADQIRAAEAPLLDAQEHPNQLMQAAAHQVFRVARELAAKGRVVLLVGKGGNGGDALYAGAELAMSGCKVDAWLAFDTAQSRALEAFRNAGGALVDSLEGDYDLVIDGILGLGGAGDLPWTLSFNAPILSIDVPSGISADTGERGANHLTADYTITFGGWRLAHALAPECGVQLLADIGGLAAQLATSPGTPIYRASGPETAWPDGITQLGAPTLGTSEPGFYDDKYTGGVVGIRAGSGTYPGAAILCTAGAVAATPGMVRYAGPQALEVVRAHPEVVATDSIDSAGRVQAWVFGPGAGTDAEAARDLEHILGTQLPVLIDADGLTLLEKHAHLRQHVLSRGNPTVVTPHDGEFARLRQTLELNETDRLHGTRELAEAMGCTVVRKGRATIIAYPDGPAEVVDTGSSWAATPGSGDVLAGIMGARIARDGVERLHESVLVHGEAAALAARTEFGVAQTSASDIARRIRAATAKLS
>NZ_CP038157.1|WP_144317674.1|879026_879965_+|Ldh-family-oxidoreductase
MKLDIDTVRTTFFDALRAHGMSEEQAESSAGVFLDAELAGKPSHGAFHLLTYLSALDNSSINGQANPTATACGSVLAIDADDGLAQFALEKHRDQLLDIARTNGVAVAAVGKTYTTGELGWYARFFARHGLISLTTTNSPALVTLNASGERVVGTNPVTFGIPEAMVVDQAATPAAFMRVRQHAERGEPLPQGWAVDAAGRPTDDASVAVDEGALLPNGGHRGGNLALVFEMLAMLAGGESSKSAANRGDEPPRVGLFALVIDPDFFGAGALGRLQAHLATLADEHEVYIPGRTRPAPAELDIDDATWEKLA
>NZ_CP038157.1|WP_144317673.1|877975_878425_-|hypothetical-protein
MTAGEVTLTRTYFLARKEDLRRCYERYLERIERVKQFTRVYLIANEEVPESSELARENLLSDLRAQSDDSLVEDEWGLYSYATALRSLDEPIAPQPPSRACGKTSYLQTRKNSPAHSLARSASPSCRGPISLSGSCILQAPATNEAGGR
>NZ_CP038157.1|WP_144318591.1|876667_877786_-|MFS-transporter
MGFAAFVYVTFETFTVGLITPMAADLRVSEGQIGLLMSVYAGIVAVVTIPLMHYTRRFNRRPLYIATLGFLLTGVVLQAIAPNYAVLVIARVTAALTHGLFWSLVNPMAARLGGKGHTGQAVAVVSMGSTMALVAGSPSVAFIGDLIGWRGATWSLGSLVIASFVVLVATLPSMPAIEPDTTAEKPSRSAIPSLIAYLGLAVTALFTTYTYLGLFVETTSGRQWVPVGLAIYGLIGIVGVLWAGRRVDLRPIRLNVVPTVLMVLAAALGLIALSTAGPGSVTAAFSSIAFLGLAAGALPTVATTVFLIAGGPNQDRASAIYVVTFQVGIAAGSALGAAAVDAGVLAGTLVVTAVSASLAGLTVSLWSRPILR
>NZ_CP038157.1|WP_144317672.1|875464_876124_+|ATP-binding-cassette-domain-containing-protein
MLTIENVTVTFPDGERTLTALDNVSFSAQPGELTFIVGESGSGKSTLLSAAAGLITPDSGTVLVSGSPVSDKIRLEKIGMIFQQANLIKALNVREQLLVTDHMRGISPRADRAEELLAVVGLEGLGGRRMEQLSGGQRQRVGIARALMGEPELVLADEPTAALDSERSHEIVTLLRTLVEQNNIACAFVTHDRSLISERDRVVEVKDGRIVDLAGVPAN
>NZ_CP038157.1|WP_144317671.1|874483_875464_+|FtsX-like-permease-family-protein
MFVGIREIKGALGRFSLIVGVVGLITLLVVMLTGLTAGLGKQNTSALEALDPQSVTFNDMDEPSYSTSRIPADEVPAGSTPLGTGQTMLTTEDGTEISAAVLGLPKGTVLPTGVTLGDTAVASSSLGLTEGEEIGVGGASISVDETADDLYYSHSPVLWVPTETWQAAMHTEAAGTVLLNSDDSGMSVRESFNALPAYGSEQGSLKLIQGFLYAIAALVTVAFLTVWTIQRTRDLSILRALGASSAYLRKDALGQAALILAVGVIGGGIIALGLGLAAAQVAPFSLSVLSIIGPQLALWVLGMAGAWLATRSITKIDPQQALGGIA
>NZ_CP038157.1|WP_144317670.1|872907_874029_-|sensor-histidine-kinase
MSNTNRILVFLRVSLHVLVAVLLAVGLAGALQEGMNVAALCLGALFAVVYLVGTVYHNEGKPYPLAAAWAWLAVITALWVALTWVSPTFVWLEFPLVILVSYLFPVVPGLLISAVILGCTLTVTAPESGVGGIVGPTIGTAMALLIYHSYSALRREADHYKQLVVDLQAAQMELAAAEHSAGVSAERARMSREVHDTIAQGLSSIVLLGRALDKQLGDTASARETLNTIRSTAADSLTEARRIVAGDAGPLEPLPVRVERLADAAQQRQRALGSHIEVRVNVVDLPEPAANVVERVVREGLSNIVRHAGATQAVVTVDRLGDQATVDVYDNGRGITGEEGFGLRGLRERLREAGGKLTIEGNVLAATLPVKER
>NZ_CP038157.1|WP_144317669.1|872299_872905_-|response-regulator
MIRVMLIDDHPIVRAGLRAVLDSFGDVHVVAEGASGAAIDEMPEGVDLVVTDIQMPEIDGIEVTRRLVAAGGPPVLILTTYDAQADVLAAVEAGALGYMLKDAPEAELHAAILQAAAGQRVLSPQIAGVLAERVMHPDEALSTREIEILQALQTGAPNREIASSLFISEATVKTHLIHIYSKLGVDNRTAAVDKARERRII
>NZ_CP038157.1|WP_144317668.1|871392_872289_-|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MATVTVVGSINADLVVEVDRHPRPGETLLGSGGEVSAGGKGANQAVACAKLGTQVCMVGAVGTDAYAEEALKYLRTSGVELSDVSAVDGPTGLAVITVDSSGENTIVVVSGANAQVDGGFVDARRGAVEGAEVVVVQGEIPASGFSAAVQLATGRVVVNLAPVIDVERADLLRADPLVANEHEAGLILTQLGELQPPATEEEKAAVLLAQGFASVVITRGAGGAVVGHGDTITPIPAPRVEAIDTTGAGDAFVGAIAARLAHGASLVDASAYASRVAALSTTRRGTQSAYPTAADELP
>NZ_CP038157.1|WP_144317667.1|870159_871392_+|Bcr/CflA-family-efflux-MFS-transporter
MAQGYLLPGCFNPGRDESVNSISRSLLVALALLSAVGPFGIDMYLPGLPTLQEDLGTTPAMAQLTITGFMLGMAVGNLLFGALSDSTGRKRPIMIASVCFFAASVLCAIAPSIELLVAARVIQGLAGGSMMVVARAVVPDIARGREAARMFSALMAITGFVPAIAPVIGGVLLPAVGWRGIFWALVVLNAVQTLVAFRVVPETLPPQMRSSRALRGLFPRIARCLARPAFVGYMLASGLGFGALFSYISGSPLVMQRQLGVSPTAFAVIFGSMAMLIPLSNAMNMRVVTRTDPRRALIAALLIDALAGALLVPQALSNPTLVLVVPTLAVLSLMAGFIMANATALGVDSVRDIGAGAGSGAMGFFQYVVAGAIPPLVALGTNPMLAMGISIIACSGIALVALATLTRRAE
>NZ_CP038157.1|WP_144317676.1|881743_882538_-|Fpg/Nei-family-DNA-glycosylase
MPEGHVIHRLAAHLNSGFRGGPLSVSSPQGRFDASPIDASSLTLAEAHGKHLFICFSTGHIVYIHLGLIGSLRFEPARDVWGQIRLRIVAGDVAANLRGPQFCRYVSPAEMQAILDRTGEDPLRDDASPDALFARVGASKRTIGSLMMDQKLFAGVGNIYRAEALFRQGVSPFVPGCQLAREDFDAVWADLVSLMRYGVEHGRIDTVRDEHTPEAMGRDPRKDDHGGEVYVYRRTGEPCFVCGEPIAVRKVEGRNLFWCPKCQG
>NZ_CP038157.1|WP_040423204.1|882548_883043_-|ribonuclease-E-activity-regulator-RraA
MPSCMATADIADLYGDQEQLASCDTQFTNYGGHTEFCGEIVTIKCFQDNGLVKKTLNSPGNGRVLVVDGHGGLHTALMGDMIAQAGVDNGWAGVVINGAIRDSAEVAKMPFGCKALGTNPRKSNKDGAGEVNVQVTFGGVVFHPGHFLYADADGVVVTAEPIDH
>NZ_CP038157.1|WP_006841268.1|883138_884434_-|isocitrate-lyase
MTTNTGKARTAAEIQKDWDENPRWAGVQRDYTAEQVEKLQGTVVEEHTLAKRGAEILWEGVNQGDGKYIHALGALTGNQAVQQVRGGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPNVVRRVNNAMLRADEIARVEGDDSVDNWVVPVVADGEAGFGGALNVYELQKAMIAAGAAGTHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVANTPTVVIARTDAEAATLITSDVDERDQQFLTGEKSAEGYYYVKNGIEPCIARAKSYAPYADLIWMETGTPDLELAKKFSEAVKAEFPDQLLAYNCSPSFNWSAHLSPEEIAKFQKELGAMGFAFQFITLAGFHSLNYGMFDLAHGYAREGMTAFVDLQNREFKAAEERGFTAVKHQREVGAGYFDSIATTVDPNTSTAALKGSTEESQF
>NZ_CP038157.1|WP_144317677.1|884870_887078_+|malate-synthase-G
MTTPTFSAHEDRTERVEVAGLQVAKPLHDFVNNSLLPEIGMDADTFWAETARYFADLTPKNKALLERRDDLQRQLDEYYRANPGQPDPKQHEQFLREIGYLVDQPRETQIRTKNVDPEFAEVAGPQLVVPITNPRFAINAANARFGSLYDALYGTDVISEDGGAEPGKGYNPVRGDKVIAWARDFLDKAVPLDGASHADVEKYSVSGGSFSATVDGRAVALAAPEVYVGFQGDVENPEAIVLRNNGLHILIQIDSEHPVGKGDKAHVKDVVLEAAVSSIMDFEDSSAAVDGSDKAAAYATWFGLNKGDISETVAKGDKSFERTQEDDLFYTSKDGEEVRLHGRAMMLCRNVGHLMTTPAILVDGEEVPEGLLDGIITVASAIPGLREDNPHRNSRTGSMYIVKPKQHGPEEVAFTNEIFDRVEQILGLPRFTVKVGVMDEERRTSVNLDACINAAADRLVFINTGFLDRTGDEIHTSMYAGPFVRKAGLQTAAWKQAYENNNVDAGIEHGLPGRAQIGKGMWAETEHMAAMVEKKIGQPKEGANTAWVPSPTGATLHATHYHQVDVFDVQEELRAAGRRDSLRDILTVPVAEGDNWSDEEKREELDNNCQSILGYVVRWVEQGVGCSKVPDIHNVDLMEDRATLRISSQILANWLVHGVVTEDQVIESLERMAKVVDEQNAGDANYLPMAADFDQSVGFQAAKDLILKGTESPSGYTEPILHAKRREFKAIHGIA
>NZ_CP038157.1|WP_144317678.1|887206_888700_+|DUF1846-family-protein
MPYTIGFDRDKYIEMQSEHISARRADIGGKLYLEMGGKLFDDHHASRVLPGFTPDNKIAMLERINDEVEIMVCVNAQDILRQKIRADLGITYEDDVLRLVDVFRERGFLVDNVVVTQLEPGNAPAEAFVERLERLGLKVSRHRVIPGYPNDTARIVSDEGFGLNEYAETTRDLIVMTAPGPGSGKLATCLSQIYHAHKRGIPAGYAKFETFPIWNLPLSHPVNLAYEAATADLDDINVIDQYHLEAYGEQVSSYNRDVEVFPLLKSLLKEVTGEEPYQSPTDMGVNMAGYCISDDTACRHAAEQEIIRRYLKERVDERRTDRDSAFSDRISNVVRKADLAVSMRTVVAPALEVAEVTGQPGAALELPNGRIVTGKTSDLLGPSAAVLLNALKELAGIPPELHLLSPDSIEPIQSLKTTYLGSANPRLHTDEVLIALSASATHNPSAARALEQLPQLRGCDAHTTTILGSVDEGIFRSLGVLVTSEPKYWKKALYHKK
>NZ_CP038157.1|WP_144317679.1|888727_889423_+|PIG-L-family-deacetylase
MELKLEPTDSVLAVVAHPDDMEYGTSAAVAKWTSEGVEVNYLLLTHGEAGISGLDPQETARVRAKEQRDACDQVGVGDLTLLEFTDGLLEHTLELRKAIAAHIRRLKPTVLLTQNFDVFAPWGINQADHRVTGLATIDAARDAANEWLYPELGEKHQATKLLIANPAEPNCAVRIGEGDLQRGVASLTQHRDYLRALPDHPAPEEIVGGAARGGGEFLGVDDAIAFAVYDL
>NZ_CP038157.1|WP_144317680.1|889431_890307_+|3-hydroxyacyl-CoA-dehydrogenase
MNKVTVLGSGVLGAQIALVTSVRGFEVAAWDINDEACASAAKRFDTFGAQMVRELDDVSADDLAAGRARLTQTTDIEAAAANADLIIEAVPENLEIKRDVWSKAGAAAGEHTILATNTSTLLPSEFADATGHPERFLALHFANHIWLNNTAEIMPHAGTDPKYVDILERFATDIKMLPVKLQKEQPGYVLNTLLVPFLNAAQYLLANGVASPEDVDKNWRNSTGAPMGPFEIMDMVGLRTVHAVGSLKPNPSASESAFHKILEEMIAEGRIGKESGQGFFAYDEEGNRVSR
>NZ_CP038157.1|WP_144317681.1|890336_891224_+|rhodanese-related-sulfurtransferase
MTSKILLYYKFQPIADPEAVRLWQRDLCAGLGLHGRIIISKDGINGTVGGDIDACKAYARKTKEYFRGIEFKWSEGGKEDFPKLSVKARDEIVAFGVPGELKVDSRGVVGGGKHLAPEEVNELVAQRGDEVVFFDGRNAREAEIGRFKNAVVPDVETTHDFINELDSGKYDWMKDKPVVSYCTGGIRCEILSSLMVNRGFKEVYQIDGGIVRYGEKYGNTGLWEGSLYVFDKRMHTEFGAPDDPAYVQLGHCGHCAEPTNQFYNCAAEPDCRSQYLSCEACRAENPYCENCSAST
>NZ_CP038157.1|WP_144317682.1|891220_891706_-|hypothetical-protein
MKDEDYVEHPENFPSSPTDRYNRVRPEPRSFDELAAGPDPVAVKERNRASTRQAIFYAAGVVIATFAVAFVLALISRLQGGPLCDAGQATWLCTPSWRMWWALGSSVVPIAGLLGCAVIMVRKLNRYERWVPWMGVFWLPIVPFTMWWLTVTVGIIALDSA
>NZ_CP038157.1|WP_170228626.1|891716_892388_-|universal-stress-protein
MPVRMAASSSDSSSLIEVARDFGADVVVLGSRSARPKGTFLVSTVADSLLDANSLPLVVAPRHPKLSRKGITRITYVYLGYDGFDYPAGLQQAARIAARLGVPIRLLAMSPDNLSGADFDANINTPSDSAEWYEAALGHLDVARDTVFEAASQAPGATVVEVDVAVDHGWKRAMHSVKWKKGDLACFAFRRQSQFKRVFFSGPTSEFLRHCPAPSLIFPPSTA

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Crispr_ID: NZ_CP038157_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_3

1085673-1086063

Orphan

Consensus_repeat	Method
GTGACATTGCACCCGCCGAGATGTCACGGTGAAGCACTCAACCGTCCCCGC	PILER-CR

4 spacers

The CRISPR arrays of NZ_CP038157_3

>merge|NZ_CP038157|3|1085673-1086063|PILER-CR
GTGACATTGCACCCGCCGAGATGTCACGGTGAAGCACTCAACCGTCCCCGCGACCTGGAGTTTTGCACTGCCGCAGCTGTTGACCGTGACATTGCACCCGCCGAGATGTCACGGTGAAGCACTCAACCGTCCCCGCCACCTGGGGTTTTACACCCCCGCAACCGTTGACCGTGACATTTCGGTGTGCGAAATGTCACGGTGAAGCGGTTGGGTGGTTTTGCGACCTGGGGTTTTGCACCGCCGCAGCTGTTGACCGTGACATTGCACCCCCCGAGATGTCACGGTGAAGCACTCAACCGTCCCCGCCACCTGGGGTTTTACACCGCCGCAACCGTTGACCGTGACATTGCACCCGCCGAGATGTCACGGTGAAGCACTCAACCGTCCCCGC

>NZ_CP038157|3|1|1085673-1086063|PILER-CR
GTGACATTGCACCCGCCGAGATGTCACGGTGAAGCACTCAACCGTCCCCGC	GACCTGGAGTTTTGCACTGCCGCAGCTGTTGACC
GTGACATTGCACCCGCCGAGATGTCACGGTGAAGCACTCAACCGTCCCCGC	CACCTGGGGTTTTACACCCCCGCAACCGTTGACCGTGACATTTCGGTGTG
CGAAATGTCACGGTGAAGCGGTTGGGTGGTTTTGCGACCTGGGGTTTTGCA	CCGCCGCAGCTGTTGACCGTGACATTGCACCCCCCGAGATGTCACGGTGA
AGCACTCAACCGTCCCCGCCACCTGGGGTTTTACACCGCCGCAACCGTTGA	CCGTGACATTGCACCCGCCGAGATGTCACGGTGA
AGCACTCAACCGTCCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_144317794.1\|1081887_1082952_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|236454
NZ_CP038157.1\|WP_144317800.1\|1091525_1092473_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213235
NZ_CP038157.1\|WP_136648973.1\|1093560_1094601_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_CP038157.1\|WP_144317798.1\|1089552_1090974_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317787.1\|1074225_1075260_+\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NZ_CP038157.1\|WP_144317796.1\|1084373_1085576_+\|acetate/propionate-family-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP038157.1\|WP_144317797.1\|1086155_1088561_-\|protein-kinase	unknown	unknown	gnl\|CDD\|319004
NZ_CP038157.1\|WP_144317793.1\|1080591_1081881_+\|adenylosuccinate-synthase	unknown	unknown	gnl\|CDD\|234904
NZ_CP038157.1\|WP_144317799.1\|1091065_1091533_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239217
NZ_CP038157.1\|WP_136648970.1\|1096902_1097847_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP038157.1\|WP_144317791.1\|1078501_1079317_-\|DUF2382-domain-containing-protein	unknown	unknown	gnl\|CDD\|378207
NZ_CP038157.1\|WP_144317795.1\|1083014_1084373_+\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537
NZ_CP038157.1\|WP_144317790.1\|1077343_1078366_-\|quinolinate-synthase-NadA	unknown	unknown	gnl\|CDD\|236489
NZ_CP038157.1\|WP_136648978.1\|1088557_1089556_-\|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
NZ_CP038157.1\|WP_144317788.1\|1075318_1076485_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP038157.1\|WP_144317789.1\|1076481_1077339_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl\|CDD\|236125
NZ_CP038157.1\|WP_136648972.1\|1094629_1096105_-\|cardiolipin-synthase	unknown	unknown	gnl\|CDD\|234967
NZ_CP038157.1\|WP_144317801.1\|1092465_1093188_+\|ABC-transporter-permease	unknown	unknown	unknown
NZ_CP038157.1\|WP_136648971.1\|1096112_1096892_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|197320
NZ_CP038157.1\|WP_144317792.1\|1079647_1080541_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_144317791.1\|1078501_1079317_-\|DUF2382-domain-containing-protein	gnl\|CDD\|378207	pfam09557, DUF2382, Domain of unknown function (DUF2382). This entry describes an uncharacterized domain, sometimes found in association with a PRC-barrel domain pfam05239 which is also found in rRNA processing protein RimM and in a photosynthetic reaction centre complex protein). This domain is found in proteins from Bacillus subtilis, Deinococcus radiodurans, Nostoc sp. PCC 7120, Myxococcus xanthus, and several other species. The function is not known.	3.20462e-32
NZ_CP038157.1\|WP_144317800.1\|1091525_1092473_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213235	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter. The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.	1.01106e-97
NZ_CP038157.1\|WP_136648973.1\|1093560_1094601_+\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.74138e-53
NZ_CP038157.1\|WP_144317787.1\|1074225_1075260_+\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NZ_CP038157.1\|WP_144317796.1\|1084373_1085576_+\|acetate/propionate-family-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP038157.1\|WP_144317797.1\|1086155_1088561_-\|protein-kinase	gnl\|CDD\|319004	pfam16918, PknG_TPR, Protein kinase G tetratricopeptide repeat. This domain is found at the C-terminus of protein kinase G and contains a tetratricopeptide repeat (TPR).	3.73927e-74
NZ_CP038157.1\|WP_144317793.1\|1080591_1081881_+\|adenylosuccinate-synthase	gnl\|CDD\|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NZ_CP038157.1\|WP_144317799.1\|1091065_1091533_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	7.49003e-20
NZ_CP038157.1\|WP_136648970.1\|1096902_1097847_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.71288e-12
NZ_CP038157.1\|WP_144317794.1\|1081887_1082952_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|236454	PRK09288, purT, formate-dependent phosphoribosylglycinamide formyltransferase.	2.78541e-103
NZ_CP038157.1\|WP_144317795.1\|1083014_1084373_+\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_CP038157.1\|WP_144317790.1\|1077343_1078366_-\|quinolinate-synthase-NadA	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	2.65539e-166
NZ_CP038157.1\|WP_144317789.1\|1076481_1077339_-\|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl\|CDD\|236125	PRK07896, PRK07896, carboxylating nicotinate-nucleotide diphosphorylase.	1.64252e-131
NZ_CP038157.1\|WP_144317788.1\|1075318_1076485_+\|FUSC-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	2.25779e-34
NZ_CP038157.1\|WP_136648978.1\|1088557_1089556_-\|glutamate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.71577e-77
NZ_CP038157.1\|WP_136648972.1\|1094629_1096105_-\|cardiolipin-synthase	gnl\|CDD\|234967	PRK01642, cls, cardiolipin synthetase; Reviewed.	4.38807e-119
NZ_CP038157.1\|WP_136648971.1\|1096112_1096892_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	3.57284e-102

>NZ_CP038157.1|WP_144317796.1|1084373_1085576_+|acetate/propionate-family-kinase
MSYVLVINSGSSSIKFQIVDPTSSASDTAFVSGLVEKIGEKDGRISVTHNGEKHDSNQPIRDHRGGLQLAVAMLDSLGVGPTQLDLVAVGHRVVHGGQTFSGPALITDEVVEQIRDLIPLAPLHNPANIDGIEVARDLLPNIPHVAVFDTGFFSELPAAAATYAINSEVAEANQVRRYGFHGTSHEFVSGQVPGILGRDSADTNQIVLHLGNGASCSAVKGGAPIDTSMGLTPLAGLVMGTRTGDVDPGIIFHLHRQAGMSIDEIDTLFNRQSGIKGLSGVNDFRDLHAKIDQGDDDAKLAFDVYITQLRRYIGSYMIALGRVDAITFTAGVGENDDATRAAALAGLENYGIVIDENRNAGPNDGPREITTDDSTVKVLIVPTNEELAIAQKSAEVAAAQ
>NZ_CP038157.1|WP_144317795.1|1083014_1084373_+|phosphate-acetyltransferase
MADQSLLITLANRNYDGIDVEGFASKRGLRVVRLDSYGTDLQEMYDAHLLAEEPALVVGTGDVSFDGELAAALGIPVVLVTAEDANVELAERRLEELGAIVAGVFSAEQLADAEIAAVEARQVMSPVVFESWLIERAKEKRAHIVLPEGEDDRILQAAAQLLEDEVVDLTILGDQADIDRRAADLGLDLSAAQILNHLESDLLEEFAADFAELRKKKGISLDDARETMKDISYFGTMMVHKGIADGMVSGAAHTTAHTIKPSFQIIKTVPGASVVSSIFLMVMRDRLWAFGDCAVNPNPTAQQLGEIAAVSAKTASQFGIDPKVAMLSYSTGTSGSGPDVDRAVEAVAAAKKADPELIVDGPLQFDAACDPGVGKKKAPESPVAGQATVFIFPDLEAGNAGYKIAQRTGDALAIGPVLQGLNKPVNDLSRGATVPDIVNTVAITAIQAGALK
>NZ_CP038157.1|WP_144317794.1|1081887_1082952_+|ATP-grasp-domain-containing-protein
MDSLTQRQVFVLGTGPVAQSSASAFADLGFDAYVGTLEEGLPQWARPEITVVCDEQVATTQQLEKLVAETGTYLVPSLDACSITRTREGIRRTAAEELGLPTMAYEFAKSVDELAGCAEAVGYPCVVKPSISAGGRGHTVVHGPDDLDAAWRRARETNPEGSVAVERYVDFDFEVTIITARSVDPETGELATWFCEPIGTRHEAGRLVEAWQPAPLSEAAMDNARSIAARITGRIGAQGVYSIELFVDGDEVYFSDVNPRPSPDGMVTLATQRIDQFDLHARAVAGLPIDVTLMTPGAACYVAGKAHSGEALARALTVEETTIHVLEETTVVRSTAEDVQQARVQAERAAHFLS
>NZ_CP038157.1|WP_144317793.1|1080591_1081881_+|adenylosuccinate-synthase
MSAIVIVGAQWGDEGKGKATDILGGKVDYVVKPNGGNNAGHTVVVGGEKYELKLLPAGVLSENAVPILGNGVVVNLEALFEEIDGLVARGADATRLRISSNAHLVAPYHQTLDRVQERFLGKRAIGTTGRGIGPTYADKVARVGLRVQDIFDESILRQKIESALDVKNQMLVKMYNRKAIEVDEMMDYFMGYAERLKPMVIDAEYTLNKALDEGKHVLMEGGQATMLDVDHGTYPFVTSSNPTAGGACVGTGIGPTRITASLGIIKAYTTRVGAGPFPTELFDKWGDYLQTVGGEVGVNTGRKRRCGWYDSVIARYASRVNGFTDYFLTKLDVLTGIGEIPICVAYDVDGERFDEMPLTQTQFHHAEPIFETMPAWDEDITGITDFDDLPQKAKDYVLRLEELSGAPMSYIGVGPGRDQTIVRNDVMER
>NZ_CP038157.1|WP_144317792.1|1079647_1080541_-|hypothetical-protein
MRLLHCQCGEGAPANAPTLSLPPIPSRADLRPLDELAKELLLVDDTPSLAEIQASPNVPHMGEPQFASQRPVERLRVIVSGSDAALGAVLTRMMRGDYLWAEVAYVPTDPTSPAAALWGTPTFEEAATAPVVPSPCIRNDFGQVVAGSATLTHINPASEFVGEIVVDSSVLLFRSGEEASARFFGSFGAKLVPAASAPGIAAAPLVTPLDTSGTPSRRSPELLERLRSLPGGRFLTRNASVFPGLADGSRVLTGRALQAGGHEIAVTVDGVRRRRGVDKATFYRHLRDIQSVRITEN
>NZ_CP038157.1|WP_144317791.1|1078501_1079317_-|DUF2382-domain-containing-protein
MADYNRIEDLANATAFDVDGDKVGGVKDVYVNDTTGQPDFVSVNHGLFGGGDSIVPLRGHTLRDGELHLAFPKERIDNAPNLDEDGHLTNEDQEAFYRHYGLEGTQDVTAYETDARHAAPVAGVATDRAAVDVDRADVDNDAIVRSEEQLNVGKERVESGQVRLRKYVVNETETVEVPVQREEVRVVREPITEADRANVDSRIGEAEASVTLSEERVTVNKETVPVEKVSLDKETVQSTERVTEELQKERIETDGVVVDENRPDTDFGANR
>NZ_CP038157.1|WP_144317790.1|1077343_1078366_-|quinolinate-synthase-NadA
MTTYLENLTRESGVWQGVEPDEEWAREIARLKHERNAVILAHNYQIPAIQDTADFTGDSLALSRKAAETDADVIVFCGVHFMAESAKILSPTKTVLIPDKDAGCSLADSITADQLRQWRSEHPDAVVVSYVNTTAEVKALTDICCTSSNAVDVVASIDPGTEVLFCPDQFLGAHVKRETGRDNIRIWSGECHVHAGISATKLAEQAEANPDADLYIHPECGCANSAIYLAGEGIIDPERVHMLSTGGMLDLAHTASPERTVLVATEIGMLHQLRGAAPEVNFQPVNDRASCRYMKMITPAALLRCLAEGKDEVDVPTDIADKARASLEAMISIGEPGGGE
>NZ_CP038157.1|WP_144317789.1|1076481_1077339_-|carboxylating-nicotinate-nucleotide-diphosphorylase
MEPLSESYLRSLIAASLEEDLAFGPDVTTLATISADATSRARFVSRAEGVTAGLDVIRYALDTPGCEVTQRVDDGERVAPGNVLAEVTAPTRTLLTTERTMLNILSHASGIATATRRWVDAVEGTGARIRDTRKTLPGLRELQKYAVRAGGGVNHRMGLGDAAMIKDNHVAAVSRGVVAALAAVRAHAPDLPCEVEVDTLDQLDALLRLSEPPQLVLLDNFSVADTAEAVRRRDQVAPGCELESSGGLTLERARAYAETGVAYLAVGALTHSVSALDIGLDYLGD
>NZ_CP038157.1|WP_144317788.1|1075318_1076485_+|FUSC-family-protein
MAKERMGTRARLLAVNESLSARVTRVRKRLLPILQTAIAAGVAFWIASEVFGHAQPFFAPISVIIIVGMTGGERISKALDISLGCVIGVAVGDLLFYRLGSGGWQIAVIVACALLIASFFSRSQLVNNQVAIGSVLIATIMPPGAEVTGIDRTIDAFVGAAVALVTLALIPQGPVGKARQEISKVMELMSSVLDDVADGLRSGNADVIDEALDLIRSSQTDIDAMSSAVASGAESARLSPFLWGSRRYVHSLEMVIPPVDTAVRTTRVLARRAHILCGDNDRVTPEQIELIDALAKASLEISDVYEVDSRKLQSVAIPRIVNDLRVLGGRAGMDVVGDNGVLSAYAILAQTRSLIVDLLQVCGMSRVSAAAVLVPTSTSPKYPPEQYS
>NZ_CP038157.1|WP_144317787.1|1074225_1075260_+|class-II-fructose-bisphosphate-aldolase
MPIATPEVYNEMFDRAKANGFAFPAINCTSSETINAAIKGFAEAESDGIIQFSTGGAEFGSGLGVKNKVAGATALAAFAHEIAKHYDVNIALHTDHCQKEVLDEFVRPLIAISQERVDRGELPLFQSHMWDGSAIPIDENLEIAKELLAKAHAANIILEVEIGVVGGEEDGVEAKSGANLYTVAEDFEKTIDALAIGEHGRYLLAATFGNVHGVYKPGNVKLRPDVLDMGQKAAIAKLGLEEGSKPFDFVFHGGSGSEKEKIEEALSYGVVKMNVDTDTQYAFTRPIAGHMFSNFDGVLKIDGEVGNKKVYDPRSYLKKAEQSMSERVIEACEDLHSVGKTLSK
>NZ_CP038157.1|WP_144317797.1|1086155_1088561_-|protein-kinase
MNERDERVEDAVDDATEAVEYDPFAGDDPATEAVAFDPFALDDDSDSDERNYAGLGDMAELFKDLDALREGRREEDTSQRSRREALDTFRELRGAKRAARAVADGMVELPWIAPTDPKEALKDPTRAVVQKGLNAPHLHPGDVVAGQYEIMGVIAHGGMGWIYVAQDRNVADRVVVLKGLHSTKNADEAAAAVAEREFLAEITHPGIVKIFNFIDDSRVPGGFIVMEFVGGPSLGQRRNEQPNGLLPVDLAIAYILEVLPALVYLHSRGVVYNDLKPDNIIVTEDQVKLIDLGAVSGIGAYGFIYGTKGYQAPEVATQGPSIASDIYTIGRTLASLVVHLPRTDGVYDPGIPSPTTEPTFRRYLSLYRLIRRCCHEDPEQRFSTVGELETQLYGVLRECIAIRDGRTYPAQHSLFSPQRTTFGTKHLVFRTDQLIDGISRTVEITPQEVVTALPAPLIDRHDVGAAMLQGTSYQEPQETLENLRQAMQTPQYEQSSEIPFGVVRAMLDLGLTYQARTWLESLKDRLSHNWRFHWYSGVTNTLIGDFQSAQANFTSVLVAVPGEAAPKLAIAAIDELILQSNGYLTGALLDDALSRAAAGIRTHLGELPSETFEAWQSKGVLAEDWTMLSDTPTVLRFNALRLYSLVWLTNPTTVSSAFGLARLLMAEREVELAVAALDKVPNSSRHHRMAQLTTILDLVSDELTESRIRRAARRLEEIPNNEPRFLQIKVYVLRAALTLLRDAGVDRAASDHSLFEYEFTTRDLRRGLATTLREQARIAPYARHRYALVDMANKVRPATWF
>NZ_CP038157.1|WP_136648978.1|1088557_1089556_-|glutamate-ABC-transporter-substrate-binding-protein
MRKFARITSAALACAALSACAPGGETRVAAPALPPPSYSGVPLPPGAVLDRPGVAPETGFAQDTEWEGSLRPDNATPAERIPDVVERGRIVVGVDQSQYLLSYRDVTAGDLRGFEIDLAREVSRDIFGDPDRVDFRFVGSQQRAQSLQNGEVDIVIRTMSVTPTRVASVDFSTPYLTSYVRLLVPRDRGILSEDDLPGTTVCVVDGSNLVQLAREIAPQSTILRTRTWADCLMATQQFHADAILADDAILAGMVAQDPYTTILPRRYGRQQYAVGTHKGDAGMTMQVNSTMERLRNDGTWNAMYERWLSGSLASPSMPELRYRATSEAKEQQ
>NZ_CP038157.1|WP_144317798.1|1089552_1090974_-|hypothetical-protein
MVQQASVIDDAPLDDAFVDELEALPENRSARVKMAETFTGPLRWVRRVIDFITTTPGQLLSMMLVLTLALIAAGVSMSQTMAARQEAMDVLVNSTEPMSNSAHTLITSLSQADTIATSTFVQPGISSEYDMNRFMESVDMAVIAANEVLEGTVDSGARDDEIRRLVLQIQRDIPVYAGLMERAKTNQRMGNPVSVAYMSSSSNVMRERMLGNATELFNLTREQVADEMERLARPQWVPLSGLVAALIFLLLAQVWLWKVFRRRLNRGFIAATVMMLIAIIWASVANYSVWQSGQRDFERASTPWEELTSARIDAQETRTDEIFALLRRQSVSDTDLTFSETYDSVSRALDSASAPPSGSTDPDLIASAREALDQWDEAHTQFAQTLGGGEFDTAVQVLTDPNPDEGLASSSRAYTRLDNALSGLIGQSRQDMREFIVASLDATSAVAGAVLAFTALSVLSIWLGIRRRLREYL
>NZ_CP038157.1|WP_144317799.1|1091065_1091533_+|NUDIX-domain-containing-protein
MEGDGNGWVEGPAGMKLWGRFGASGLFLQAGGRVLLQHRATWTAQGGTWALPGGARDSHETVEQTALRETVEECGIDPSLITVTSAMVTAGPFPSGWTYTTVFASTNTGEPIPVEPNEESAELRWVPVDGIRALPLHPGFEASLDAVVGHTKPHD
>NZ_CP038157.1|WP_144317800.1|1091525_1092473_+|ATP-binding-cassette-domain-containing-protein
MIDVHNLTKHYGPVRAVDDLTFTVKPGVVTGFLGPNGAGKSTTMRMILGLDSPTSGTALIDGSPYASLKQPARRVGALLDAKGVHPNRSARASLLWQAQASGIPDARVDEVMSLVGLSDVASKRAGGFSLGMGQRLGIASALLGDPEYLILDEPVNGLDPEGIRWVRGLLRALADEGRTILVSSHLLAEMAQTADHLIVIGRGKLVADTSVHDFIKGNSAVTTVVRPVDPAAMETALAAAGVSFERVVDAEGRPTIAVADHTCDEIGAVAFRAGVQLAELSERRASLEDAYIRSTEGHIQYQAQSQDTSGGKHRA
>NZ_CP038157.1|WP_144317801.1|1092465_1093188_+|ABC-transporter-permease
MLNLVRAEFTKLRSTASFYWTTGLILAIAAIFAVAFAAPAGSLYFPITVIMAVSMISAIIVIVQSAMVVTTEYRFGLQTTNFRLAPQRWQVAVAKLALYAVLAALTVLVALIIAFTLADALADVPANWTSNPATLRALWAVPLATATLTMLTQGVGWIVRNTAGTVTLVFAFQFVVETIVGFIPGIGRDIAQYLPFSNYYAFVTNAPAQHDNVWVSYGIFLAWAVVAWVAGVVLLHRRDA
>NZ_CP038157.1|WP_136648973.1|1093560_1094601_+|MFS-transporter
MGYIADNRGRKFALLTCLVLFVTLTAAIYVVPSFSLFIFLRLLAGIGLGGVWSVLSAYVTETWPAHQRGKAIGFVLAAYPIGSALAAQLSSFLMPDWRLLFLIAGLSAMLPLAFVLIGFRESEVWKRDRGVTQEGESVSIKALFTGGRARLTIIASIVCILVMVPYYGATTWFPSYLARERAFDAQTIGNHFTLMSLTAFLGYFFFGWLADKVGRKPAIMASLISTGLLIAAYGYSTSPSILWVVAPLYSFCMVFPGLFAPYISELYPTRMRTTGSGFTYNVGRGLSALGPIVMGGIATAASFSTGIVIAGGLFLLAAVIMLTLPRVDAVTADDTEELGEREAVAV
>NZ_CP038157.1|WP_136648972.1|1094629_1096105_-|cardiolipin-synthase
MSFSLDISYWQLVAMLVDYAIKFVMIGIVPSNRRPSAANAWLLLILLLPFIGLPLYLLMGSNFFNRRRHRIQQRVRAEIDNVHTDIPDLPPDANLGADKEAIVRLHRALTGFPAVDANLRHVWSDYELAIRRIAQLIDASENYVDVEIYAVAWDDTTGIVFEAMERAVARGVHVRLLLDHIGSQKYPGYRRMTRKLTRAGIDWYLMLPLQPWRGRFRRPDLRNHRKVVIVDGHIAMMGSLNLIDRSYLMRNHRRAGRQWIDVFIEFEGPIVTSLESMFAVDWYTESGEAIELLPPRRLGVDKPGEHIVQLIPSGPGYETEPNLRMFNTLIHHARERLILCSPYFVPEDSLLEAVTTACYRGVRVDLLVGEKADQFMVNHAQSSYYEQLLRAGVHIWQFPAPYILHTKFALADPGRDTFVGVVGSSNMDMRSFSLNYESSLFVASGSLLDDLYTLARTYMNVSDELTLEEWSRRPWHRRYIDNVMKLTSALQ
>NZ_CP038157.1|WP_136648971.1|1096112_1096892_-|endonuclease/exonuclease/phosphatase-family-protein
MRIATFNVNSVRSRAERIVAFLERNDVDVLAMQETKTSDAKFPYAVFEAAGYEVAHVGTNQWNGVALASRVGLDDVNTQFDHQPAYDGNVEARAVGATCGGVQVFSLYVPNGREIGHPHYDYKLQFLYSLQHAVEAQTPQLFTGDFNIAPRDDSVWDIAWFEGKTHVTEPERAAFQMLLEAGLEEIRHDDAYSFWDYKAMRFQKNQGMLIDFLLATPPVASKLVKAWVDVDERRGKGASDHAPVIADIDTTAFAYDEVR
>NZ_CP038157.1|WP_136648970.1|1096902_1097847_-|GNAT-family-N-acetyltransferase
MSRFFRSDDIAPGDRVVVRQRIGEHASDVIGHVLSLDPLVIRPQEVGGFPSFKDAIEIDNVHIVKKLSPRTVRNSDIRAVEVAYAKAFPGQEQRLVDGWLARAGADIAERSNSATPIGYSAGFNPVPLEELTDFYRQRGKPLQLLIPERIGKPVLKILTPQWKLGEEILVMTRHLDGGEIAADFEVLDTPDEAWLSMYHFRGQPLPADAIRPIDGRIAYARLTRDGDTVAVTRATLTESEDGRVWLGYSAVEVAPALRRRGLGTALGAALMAWGASHGADEAYLHVRAGNAAAIGLYQKLGFVEHHRQRYALLG

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Crispr_ID: NZ_CP038157_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_4

1119735-1119848

Orphan

Consensus_repeat	Method
GAGATGTCACGGTGAAGTCCCGGCCCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP038157_4

>merge|NZ_CP038157|4|1119735-1119848|CRISPRCasFinder
GAGATGTCACGGTGAAGTCCCGGCCCCGGACAAAACCCCAGGTGGGCACCGGCCTGAATCCGTTGACTGTGACATTCCACCCGCCGAGATGTCACGGTGAAGCCCCGGCCCCGG

>NZ_CP038157|4|3|1119735-1119848|CRISPRCasFinder
GAGATGTCACGGTGAAGTCCCGGCCCCGG	ACAAAACCCCAGGTGGGCACCGGCCTGAATCCGTTGACTGTGACATTCCACCCGCC
GAGATGTCACGGTGAAGCCCCGGCCCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_144317808.1\|1108968_1109505_-\|acetyl-CoA-acetyltransferase	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317822.1\|1128088_1128991_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NZ_CP038157.1\|WP_144317813.1\|1117088_1117319_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144318601.1\|1118549_1119266_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|236115
NZ_CP038157.1\|WP_144317823.1\|1130367_1132785_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
NZ_CP038157.1\|WP_144318600.1\|1114972_1115548_+\|excalibur-calcium-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|214891
NZ_CP038157.1\|WP_153257536.1\|1117353_1117524_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317815.1\|1119931_1123711_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|274093
NZ_CP038157.1\|WP_144317817.1\|1124233_1124533_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP038157.1\|WP_144317819.1\|1125386_1126211_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP038157.1\|WP_144317812.1\|1115565_1116612_-\|lipase	unknown	unknown	unknown
NZ_CP038157.1\|WP_144317821.1\|1126835_1128089_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|224938
NZ_CP038157.1\|WP_144317810.1\|1111881_1113519_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP038157.1\|WP_144317818.1\|1124568_1125285_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|320678
NZ_CP038157.1\|WP_144317811.1\|1113697_1114282_+\|DUF2335-domain-containing-protein	unknown	unknown	gnl\|CDD\|370814
NZ_CP038157.1\|WP_144317820.1\|1126232_1126766_-\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP038157.1\|WP_144317809.1\|1109899_1111237_-\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|236127
NZ_CP038157.1\|WP_144317816.1\|1123721_1124177_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP038157.1\|WP_144318602.1\|1129708_1130353_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
NZ_CP038157.1\|WP_170228635.1\|1117642_1118545_+\|polyphosphate-kinase-2	unknown	unknown	gnl\|CDD\|213852

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_144317822.1\|1128088_1128991_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	7.13477e-48
NZ_CP038157.1\|WP_144317820.1\|1126232_1126766_-\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	7.32871e-80
NZ_CP038157.1\|WP_144318601.1\|1118549_1119266_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|236115	PRK07854, PRK07854, enoyl-CoA hydratase; Provisional.	1.81056e-60
NZ_CP038157.1\|WP_144317823.1\|1130367_1132785_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP038157.1\|WP_144318600.1\|1114972_1115548_+\|excalibur-calcium-binding-domain-containing-protein	gnl\|CDD\|214891	smart00894, Excalibur, Excalibur calcium-binding domain. Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognised and the evolution of EF-hand-like domains is probably more complex than previously appreciated.	4.24665e-17
NZ_CP038157.1\|WP_144317815.1\|1119931_1123711_-\|AMP-binding-protein	gnl\|CDD\|274093	TIGR02353, NON-RIBOSOMAL_PEPTIDE_SYNTHETASE, non-ribosomal peptide synthetase terminal domain of unknown function. This domain is found exclusively in non-ribosomal peptide synthetases and always as the final domain in the polypeptide. This domain is roughly 700 amino acids in size and is found in polypeptides roughly twice that size.	0
NZ_CP038157.1\|WP_144317817.1\|1124233_1124533_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	3.79764e-27
NZ_CP038157.1\|WP_144317819.1\|1125386_1126211_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00254747
NZ_CP038157.1\|WP_144317821.1\|1126835_1128089_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|224938	COG2027, DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane].	5.55129e-57
NZ_CP038157.1\|WP_144317810.1\|1111881_1113519_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP038157.1\|WP_144317818.1\|1124568_1125285_+\|hypothetical-protein	gnl\|CDD\|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	8.42738e-05
NZ_CP038157.1\|WP_144317811.1\|1113697_1114282_+\|DUF2335-domain-containing-protein	gnl\|CDD\|370814	pfam10097, DUF2335, Predicted membrane protein (DUF2335). Members of this family of hypothetical bacterial proteins have no known function.	0.000201058
NZ_CP038157.1\|WP_144317809.1\|1109899_1111237_-\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|236127	PRK07907, PRK07907, hypothetical protein; Provisional.	0
NZ_CP038157.1\|WP_144317816.1\|1123721_1124177_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.47085e-14
NZ_CP038157.1\|WP_144318602.1\|1129708_1130353_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	3.13488e-84
NZ_CP038157.1\|WP_170228635.1\|1117642_1118545_+\|polyphosphate-kinase-2	gnl\|CDD\|213852	TIGR03707, PPK2_P_aer, polyphosphate kinase 2, PA0141 family. Members of this protein family are designated polyphosphate kinase 2 (PPK2) after the characterized protein in Pseudomonas aeruginosa. This family comprises one of three well-separated clades in the larger family described by pfam03976. PA0141 from this family has been shown capable of operating in reverse, with GDP preferred (over ADP) as a substrate, producing GTP (or ATP) by transfer of a phosphate residue from polyphosphate. Most species with a member of this family also encode a polyphosphate kinase 1 (PPK1). [Central intermediary metabolism, Phosphorus compounds].	9.17578e-149

>NZ_CP038157.1|WP_144318601.1|1118549_1119266_+|enoyl-CoA-hydratase/isomerase-family-protein
MVTSSAHGSVVVVTLNRDEKRNALSTELIRELGSALDDAQHSARAIVLTGAGSVFSAGADLDENEFQGSFFDDFFTVIRALRTAAAPIIAHVNGLAIGAGMMLTMACDIRVAAQSARFVLPVGDMAIGVNEWVVRTLTELLGGSRARAMLLAGAALDVDTAVTSGYATAGSFEQAMELAELVAGKAPLTLRNVKAEFAPDLFTAAEREAALRAPFESDDIKEVGRARSEGRPVLFRGL
>NZ_CP038157.1|WP_170228635.1|1117642_1118545_+|polyphosphate-kinase-2
MAQDHKEDDLPMINLAEIEGYWVDDSDDDDPVLLKSDGTPIETWRENYPYDERMSRDEYEKTKRALQIELLKWQNWTKDTGQRHIILFEGRDAAGKGGTIKRFNEHLNPRGARTVALEKPSPRESTSWYFQRYIEHFPSAGEIVFFDRSWYNRSGVERVMGFCTESQHAEFLREVPMLENMILGSGISLTKFWFSVTQKEQRTRFAIRQVDPVRQWKLSPMDLASLDKWDDYTRAKEEQFRYTDTDESPWITIKSNDKKRARLNAMRYILSKFEYTNKDHEVVGEPDPQIVKRGRDQIGD
>NZ_CP038157.1|WP_153257536.1|1117353_1117524_+|hypothetical-protein
MQTLGTLSSLVDGSSALNLGSSLAGIALDPALALVTFMKPFVDIADGLATLLGLIA
>NZ_CP038157.1|WP_144317813.1|1117088_1117319_+|hypothetical-protein
MDLDMIITHLDNFVDTWKGWGKVLGGLNDLVNFELGSILQLSSGFDEASSDIITTSSNGVELSSGLIQFNDIESND
>NZ_CP038157.1|WP_144317812.1|1115565_1116612_-|lipase
MTTETQWVKAPEGDVPAAPSGGTTYRVRYQAQGARAEVPMTGLVTIPANPRPDGAIVSWAHGTTGLSTSSAPSLYAEGDPIERYIPHWTRFLQGWLDAGYIVTQPDYEGLGVEEVGGTYMHRGSLASAINRLVEETAAKFSPGANWVNVGFSQGGYAALAAADAPADNLLATVAIAPGDTELVNKNLRLMGIRPVDVAKMLKGKGVRFFPIVIAGALNAFEGVHASDFLSERGAELVEKAEQVTLPELTDFVTDVSGGELFISKADTRKMQNLLDEQRLELMEPKGPILVLAGDSDTTINREAVKATIASWKGKGVDVEYREVPDSDHNGSVNNSYDLQVEWIAQHVG
>NZ_CP038157.1|WP_144318600.1|1114972_1115548_+|excalibur-calcium-binding-domain-containing-protein
MGMITPPNRVDRRWPLVVGAAVTSFVLGGLISPPTAPDEASATAETSTPPMTVSSTTSSPPTTTRNTEAEASSSRAAALSSSAAASSSALVESIRAEERAKLEQEMAESSRASPLSEAEQQNVPQGFVAPAPEPTRAPAPAAVPAPAQSASYGNCTAVWNAIGSPIYQGQPGYGSHLDRDGDGVGCEKDPR
>NZ_CP038157.1|WP_144317811.1|1113697_1114282_+|DUF2335-domain-containing-protein
MSDDSNSRHPHSSRPSTGRGLDGNESAPIEDSETNSGTLAPSDDTQGLGQDVSSSRREHRRHRDQEVYEAELVTRRELLQASEYWSAPAPSPETLAKYLEIDPTLAERAFSMAEQSVAASNDEIITLAHGDVDALRRGQWMSFIMFVLSIGTALVAFALSESAALAGLFLAPAVLQFLGKFIRTVRMGEKNGGE
>NZ_CP038157.1|WP_144317810.1|1111881_1113519_+|chaperonin-GroEL
MAKMIAFDEEARRSLENGLNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVTIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIQAATERVSKYLLESAKEVETQEQIASTAGISASDPEIGEKIAEAMYAVGNGAVNKESVITVEESNTFGVDLEVTEGMRFDKGFISAYFATDMERGEAVLEDPYILLVSAKISNVKDLLPVLEQVMQSGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDLAILTGGQVISEEVGLSLETADLALLGQARKVVITKDETTIVQGAGEQAQIDGRVKQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKEQKLRIEDAVRNAKAAVEEGIVAGGGVALLQAAKELEGDLGLEGDEATGVKIVRESLSAPLKQIAFNAGLEPGVVADKVAHLELGHGLNAATGEYVDMMAAGINDPAKVTRSALQNAASIAGLFLTTEAVVADKPEPAGAGAGMDPEAMGMM
>NZ_CP038157.1|WP_144317809.1|1109899_1111237_-|M20/M25/M40-family-metallo-hydrolase
MTLPTPDRDRIFADLSALVSFNSPHSVPALADSHEAACAWTVTAFEQLGFSVERHPTIDNADTIIANRAGEEGAPTVLLYSHYDVVPAGDPAAWTSDPFMLTERAGRWYGRGSADCKGNIAMHLEAIRLLDAAGGTRANLKVVIEGSEEFGGRGGLERLIETSPELFAADVILIADSGNVAAGTPTLTTQLRGGAQVEVSVTTLEGDIHSGSFGGAAPDAADALVRIASSLFDEHGRTTIDGVDCFGKWEGDAYDRDIFRHDAGVLEGVQIYGTVDDEPADMVWARPAVTMIGFTSRPVAEALNAVNAHASAQFNLRVPAGMSAAETVEKLEEHILAHTPWGAQVNVEISQVNEPFATDITGPAITLLGESLKEAYGENSLAVVGSGGSIPLTTTLQEHFPDAEIALYGVEEPMCGIHGVDESVDPTEIERIAVAEAQFLLEYGA
>NZ_CP038157.1|WP_144317808.1|1108968_1109505_-|acetyl-CoA-acetyltransferase
MAPTVTSTAPSTRFTTAFAPTEDRDPFQIRFEIDQKLPKELRAEAQGMDWGLFKATYAPTPTMHIGLTNIEKLNWSDHHYTAEITHTSKTKSPSTSVCEVIATGPTAAISEILSTNGRYVEILAFHQINLFEATLTCVKVAHQVNHNRTAWAVGFGHSPAHSIAAALSSGAQRIYGNF
>NZ_CP038157.1|WP_144317815.1|1119931_1123711_-|AMP-binding-protein
MSSLLRAQLAPAPRTLIDVLTATAETHPDAAAIDDGSGDVLTYAELIDQVSDLAAELHRSGIRRGDRIGVRMASGSRQLYIAILATMWAGCAYVPVDADDPEERAELVFGEAGISGLFSDEGFRVLAPARPGDTDLPHLDDDCWIIFTSGSTGTPKGVAVTHRSAAAFVDAEARLFCQDAPLGPDDRVLAGLSVAFDASCEEMWLAWGHGACLVPAPRSLVRSGQDLGPWLIRRDITVVSTVPTLAGLWPAEALDNVRLLIVGGEACSQELVERLATPDREMWNTYGPTEATVVASAARLEPGKDVTIGFALDGWDLHVADDGELIIGGVGLARYLDPVKDAEKYAPVPGLDWDRAYRTGDNVRLTDDGLAFIGRADDQVKIGGRRIELGEVEANVAALPGVYNSAVAVQTTGAGDTVLVGYLSPEAGTDLDVAELRERLAEVMPAALVPRLHVMEELPIRTSGKVDKKALPWPLPASVEVTGMTPTELWLAEVWLDVLGLPAESRDADFFELGGSSLAAASLVARLRERVPTIAVRDLYDHPRLEALAGVIDAHGVAAEVVTRDVAPVGRGTRVAQTLIQVPVMTLHAATFVTWWAIIATALGWVSLNWVALAVLFIVVCTPLGRLPLAALGARAIRGRLQPGNYPRGGRVHVRLWAAERWVAATGALNISGSTWVAYFARLLGAQVGRGVDLHTVPPVTGLLTLGDNAAIEPEVDLSGYWLDGDILRVGTVTIGKDARVGARSTLLPGADIHAGAHIEPGSTVTGDKPVKKGARWAGSPARKVGRSKQRFPDYHPPRRRYWAWLYGATALLLAAVPVASALAGVAAVVGLIRLTAGSPYVGALLFAPVGALVYLALYATLTWAGVRLCSLGLRPGVTPVRSAQGWRLWTITRLLDDARTRFFPVYAGGLTPAWLRLLGATVGNDVEVSTAVMIPKLTTIKDGAFLADDTLVGTYELGHGWMRTGETTIGKRAFVGNSGITQPGRKLAKNSLVAVLSSTPKKSKSGSNWWGSPPERMRRVEVTALGGEALTYRPSASVKRKRGAVETLRLLAPMGHAVLAAAFIALVHFALVQLGWWAYALGGLAFMAVGIAAVLMTALVKWVCVGRHRPGEHPLYSWFVWLNELQDQFVEMVAAPWFFTHAYGTGELNVALRILGVKVGRGAWIDSYWFPETDLCVVGAGATVGPGTVVQTHLFQDRVMSLDTVTVGDGATLAAHSVALPAAVIGPGATVWPGSLMMRGDQVPGSTAWQGNPIEPRG
>NZ_CP038157.1|WP_144317816.1|1123721_1124177_-|MarR-family-transcriptional-regulator
MLQIELPSALIKSPSFQIERVRRHTKDEVERALNNQGATMREFWILTCVTEQSVSQTQLAELLAIDASDMVRLIDSLEAHGWVTRERDPKDRRRQIVTPTKKGSKAQALLASEVAAAEDRALDVSTTKQLKSLKKLSKAILQETDPATVSK
>NZ_CP038157.1|WP_144317817.1|1124233_1124533_-|rhodanese-like-domain-containing-protein
MKTVKVTEVPAGAQLIDVREPDEFTEVRAEGAVNLPLSDFAAQAGKINTDEDIYVICKSGGRSAQAAEYLEQARGLDNVVNVEGGTTAWVEADLPHQRG
>NZ_CP038157.1|WP_144317818.1|1124568_1125285_+|hypothetical-protein
MPEQYHPRRPPAVAPAPRRALPREIYVRRRVAALVLLGLVIILVFAVARQCAVSEPAPAEQPVPADVPQEIAQSRPVALVVPSISLSAEFEQADCRVKDGAINPATMGLACAYTAPDRPYELPGSDAGDVVVIAGHTGAGLPGVFDQLYDARAGAHTVAEGDALYVRTETSGENWLKYVATDLHDPTKDALAQDPAVWGTGPTPGRLLTISCIQPLLSDSVRNAVVGWQFAEVVAGVP
>NZ_CP038157.1|WP_144317819.1|1125386_1126211_+|hypothetical-protein
MKRNRTTLIAATLTGALAIATVPAAHAEDYPSVTSDAQGNEYFLNNEGTHYLPERELADIAFTALTSEDREKAVEVSRSAVAGLIDTGEAIAPSNADAPTESAAEIADDVTHEVQNEEVFGPEHVDPASEDPIAAGLLALPPVLSIADKTYYLNADGKTYVSDVERVSAAPSEEEATASQELLAHNGAEVARQAIEAARAAGEPVAYAAEGAPAEAAEIAEDAPAAATAEPVATTQRGMAAETGNNTISKALFALVIASALGAAAFAYGRRFLV
>NZ_CP038157.1|WP_144317820.1|1126232_1126766_-|inorganic-diphosphatase
MAIEVIIEIPKGSRNKYEVDHESGKIFLDRYLFTPMAYPADYGFIDHTLGDDGDPLDALVVTPEPVFPGVTVIARPVGVFKMTDEAGGDDKLLCVLDDVRYESFQDIDDIDDFTKDEIEHFFMHYKDLEPGKEATGSGWGDRAEAEKILQAALDAYEKTGDNSRERLEEDKEAKTEN
>NZ_CP038157.1|WP_144317821.1|1126835_1128089_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MKVWTSVMAAVALAAVGGVAGFGVVAQRELAELTVAPAYALPAVTPVLEPATPQPVDTAARAAEVAALAADEALGTFHARITDAATGETVFESAPNDALRPASSTKLLTGSAAIVELGATDTITTEVVRGLNPGEVVIKAAGDVWMNQESIDSLAEQIGSADTVLIDTSLWTGETMLPGWNPVDIDAGFIAPLEPAMLNGGRGLGAESGDVPRSHTPAIDVAQALADSVGATTVGPGTAPAGAEVVATTTSPDLVARLRAMMKDSDNVMAEAIGREVAIHRGSTAPQATLDVLAEHGFTTAGTTLTDSSGLSTLNLITPALLDAVLLSAAQGGEIAPLLDTLPVAHGEGTLYDRFEDLPGRGWVRAKTGTLDYTSALVGTVTSENGNVYTFALLSNDSEILPARRAMDTLTSALRKY
>NZ_CP038157.1|WP_144317822.1|1128088_1128991_+|tRNA-lysidine(34)-synthetase-TilS
MEPFWPRYSPHFLACRRSLRALHDPAVIGLSGGADSLALVAAAAAEDKDVRAVIVDHQLQEGSDQVARCAAEQADAWGVEASVIAVNVGGDNLEAAAREARYAALLSFGVDVWVAHTADDQAETLLLGALRGNPSGMAARGGIDNRILRPFLGIRRADTRGACAELGVTPWEDPMNVDENYRRVAVRRRVIPQLDELIGGDCVAALAATAGRIAADRELIEELCDTSATSDCVELANDAAPLRRRRIVAWLHDSGVRVDGAQLRSIERLITDWHGQAGIDVGGSRRVRRVAGRLVLDELR
>NZ_CP038157.1|WP_144318602.1|1129708_1130353_+|hypoxanthine-phosphoribosyltransferase
MHDTLDANVPAHPYGDDVESILISEDQLGARVQELADLVSEKYRDADDDLILVCVLKGAVFFLTDFARRLSIPCQLEFMAVSSYGSSTTSSGVVRILKDLDKDIAGRDVLIVEDIIDSGLTLSWLMKNLNGRGPKSLNVITLLRKPEVQTAKVDLLDIGFDIPNEFVVGYGLDYAERYRDLPFVGMLHPRVYSDVDNGEQPTPGRATGPESVEI
>NZ_CP038157.1|WP_144317823.1|1130367_1132785_+|ATP-dependent-zinc-metalloprotease-FtsH
MDNNKVLRWGIFGATALIVLYLFTLIGDETRSYQTVDTSVALEQLQNNNAQEVQIDDREQRVRIDLREPITVDEREGVESVMAQYPARTSPEIFNAVRSSGADSFETNVTQDSFLLSMLGFMLPMILIFGLLFYLMYRMQAGGGMFGIGGSRAKQLTKDNPTNTFADVAGADEAVDELQEVVDFLQDAEIYEQLGAKIPRGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFKQARENAPCIIFVDEIDAVGRQRGSGTGGGHDEREQTLNQLLVEMDGFGPREGIILIAATNRPDILDPALLRPGRFDRQIPVTNPDLAGRQQILKVHAKDKPLGPDADLDALAKRTAGMSGADLANVLNEAALLTARIGGNVITADALEEATDRVIGGPRRSSKIISEKEKKVTAYHEGGHTLSAWALKDIERVYKVTILARGRTGGHAMTAQEDDKGMYNRDELFARLVFAMGGRAAEELVFGEPTTGASSDIEQATKIARAMVTEYGMSSVLGAVKYGTEQGDPFSMYGAGNKAEYSPAVAETIDREVHELIDVAHQRAYSILADNRDYLDTLATKLLEKETLRRPDLEAIFDGIEPRESGLPVVDERFVAQAGREPVKTPVELAKERGEEPPAKVSLLEMSRNARKRRMAEREAEKKNDKTGSTKWRPGDKRVVEQPRYGGPTPPPNWTYPGAGRHAQPEPQAQPEPQPTVTNEHPGMRNYAQPDTPIGFKLPENEQPDHPWTDAEKTTESARHATPEETPKRDAADVAKPDSPGSAETTEIPRVRDDNER

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Crispr_ID: NZ_CP038157_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_5

1140345-1140559

Orphan

Consensus_repeat	Method
AACCCGTTGACCGTGACATTCCACCGCCCGAGATGTCACGGTCAACCC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP038157_5

>merge|NZ_CP038157|5|1140345-1140559|PILER-CR
CCGTTGGCCGTGACATTTCACCGCCCGAGATGTCACGGTCAACCCAGAACCGCGACAACTGACCTGGGGTTTTACACTGGGCAACCCGTTGACCGTGACATTCCACCGCCCGAGATGTCACGGTCAACCCAGAACCGCGACAACTGACCTGGGGTTTTACACTGGGCAACCCGTTGACCGTGACATTCCACCGCCCGAGATGTCACGGTCAAGCC

>NZ_CP038157|5|2|1140345-1140559|PILER-CR
CCGTTGGCCGTGACATTTCACCGCCCGAGATGTCACGGTCAACCCAGA	ACCGCGACAACTGACCTGGGGTTTTACACTGGGCAAC
CCGTTGACCGTGACATTCCACCGCCCGAGATGTCACGGTCAACCCAGA	ACCGCGACAACTGACCTGGGGTTTTACACTGGGCAAC
CCGTTGACCGTGACATTCCACCGCCCGAGATGTCACGGTCAAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_006840589.1\|1150601_1150772_+\|DUF4236-domain-containing-protein	unknown	unknown	gnl\|CDD\|379423
NZ_CP038157.1\|WP_144317827.1\|1134578_1135037_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|238269
NZ_CP038157.1\|WP_144317835.1\|1143710_1145408_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
NZ_CP038157.1\|WP_136648939.1\|1135033_1135501_+\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650
NZ_CP038157.1\|WP_144317825.1\|1133353_1134205_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
NZ_CP038157.1\|WP_136648928.1\|1149749_1150529_-\|zinc-transporter-ZupT	unknown	unknown	gnl\|CDD\|235253
NZ_CP038157.1\|WP_144317834.1\|1142850_1143714_+\|PRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|170086
NZ_CP038157.1\|WP_136648930.1\|1145568_1148307_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|214361
NZ_CP038157.1\|WP_144317826.1\|1134197_1134575_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
NZ_CP038157.1\|WP_144317833.1\|1140811_1142821_+\|PTS-glucose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|273919
NZ_CP038157.1\|WP_136648926.1\|1152303_1153017_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237019
NZ_CP038157.1\|WP_144317831.1\|1138063_1139626_+\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP038157.1\|WP_136648927.1\|1151671_1152292_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239473
NZ_CP038157.1\|WP_144317828.1\|1135505_1136513_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236138
NZ_CP038157.1\|WP_144317830.1\|1137221_1138013_+\|pantoate--beta-alanine-ligase	unknown	unknown	gnl\|CDD\|223491
NZ_CP038157.1\|WP_144317836.1\|1148303_1149659_-\|lipase	unknown	unknown	gnl\|CDD\|367570
NZ_CP038157.1\|WP_144317829.1\|1136513_1137221_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_136649054.1\|1150785_1151649_-\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP038157.1\|WP_170228636.1\|1139724_1140210_+\|TM2-domain-containing-protein	unknown	unknown	gnl\|CDD\|377473
NZ_CP038157.1\|WP_144317824.1\|1132774_1133350_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_006840589.1\|1150601_1150772_+\|DUF4236-domain-containing-protein	gnl\|CDD\|379423	pfam14020, DUF4236, Protein of unknown function (DUF4236). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 69 and 402 amino acids in length.	0.00011609
NZ_CP038157.1\|WP_144317827.1\|1134578_1135037_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	2.13903e-56
NZ_CP038157.1\|WP_136648926.1\|1152303_1153017_+\|hypothetical-protein	gnl\|CDD\|237019	PRK11907, PRK11907, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	0.00124886
NZ_CP038157.1\|WP_136648939.1\|1135033_1135501_+\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	7.87009e-26
NZ_CP038157.1\|WP_144317825.1\|1133353_1134205_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	6.14466e-100
NZ_CP038157.1\|WP_136648928.1\|1149749_1150529_-\|zinc-transporter-ZupT	gnl\|CDD\|235253	PRK04201, PRK04201, zinc transporter ZupT; Provisional.	1.6429e-113
NZ_CP038157.1\|WP_144317834.1\|1142850_1143714_+\|PRD-domain-containing-protein	gnl\|CDD\|170086	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional.	2.84628e-33
NZ_CP038157.1\|WP_136648930.1\|1145568_1148307_+\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|214361	CHL00095, clpC, Clp protease ATP binding subunit.	0
NZ_CP038157.1\|WP_144317826.1\|1134197_1134575_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	4.87942e-43
NZ_CP038157.1\|WP_144317833.1\|1140811_1142821_+\|PTS-glucose-transporter-subunit-IIA	gnl\|CDD\|273919	TIGR01995, beta-glucosides_PTS_EIIBCA, PTS system, beta-glucoside-specific IIABC component. This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.	6.70597e-139
NZ_CP038157.1\|WP_144317831.1\|1138063_1139626_+\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP038157.1\|WP_136648927.1\|1151671_1152292_+\|carbonic-anhydrase	gnl\|CDD\|239473	cd03378, beta_CA_cladeC, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	1.81736e-57
NZ_CP038157.1\|WP_144317828.1\|1135505_1136513_+\|hypothetical-protein	gnl\|CDD\|236138	PRK07994, PRK07994, DNA polymerase III subunits gamma and tau; Validated.	4.47166e-08
NZ_CP038157.1\|WP_144317830.1\|1137221_1138013_+\|pantoate--beta-alanine-ligase	gnl\|CDD\|223491	COG0414, PanC, Panthothenate synthetase [Coenzyme metabolism].	1.47402e-42
NZ_CP038157.1\|WP_144317836.1\|1148303_1149659_-\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	9.31638e-48
NZ_CP038157.1\|WP_144317835.1\|1143710_1145408_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	9.35229e-171
NZ_CP038157.1\|WP_136649054.1\|1150785_1151649_-\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	2.40776e-91
NZ_CP038157.1\|WP_170228636.1\|1139724_1140210_+\|TM2-domain-containing-protein	gnl\|CDD\|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	3.38584e-11
NZ_CP038157.1\|WP_144317824.1\|1132774_1133350_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	2.79995e-114

>NZ_CP038157.1|WP_170228636.1|1139724_1140210_+|TM2-domain-containing-protein
MSTIYPGPNHEEFDRDGLPIRKKGSAGAQPSNPFAQTYAAADPYAAADPFVTVQPQYPVQPSAYPPVPYAQTPYAVAPKSKIVAALLFFFLGSFGIGNFYLHQNKRGIAKLILTFVGFITAIILIGFVILAAVGFWALIETILVLVGAGGYDRDGRGVPLD
>NZ_CP038157.1|WP_144317831.1|1138063_1139626_+|lysine--tRNA-ligase
MTNQSQDISEQQQFRRAKRQKLIDDGRGAYPVSVDRTTSLKDLRSAYVVVAEDDEHTPPEGVTALGPGEETQDVVSVAGRIMFKRDTGKLCFASLQEGDGTQLQVMLSLAEVGADALASWKDDVDLGDIVSVTGRVIASKRGELSVMASSWQMASKALRPLPVAFAEMNEEQRVRHRYTDLIMRSAARDNAMTRIKVIAAVRKYLTGLDFVEVETPMLQTLHGGAAARPFVTRSNALDIDLYLRIAPELYLKRCVVGGIERVFEINRNFRNEGVDSSHSPEFTMLETYQAWGTYADGAKLTKGLVQFCAEEVFGSQKVTLADGTVYDFSGEWKVLQMYPSLNEALARKFPGQPEVTIDSTVEELTAIAEAIGLKVPANAGWLHGKLVEEIWEELCSDQLYEPTFVTNFPVETSPLTRDHRDQPGVTEKWDLYIRGFELATGYSELVDPVIQRERFVDQARLAAHGDDEAMVLDEDFLAAMEQGMPPTAGTGMGVDRLLMALTGLGIRETVLFPMVKPETN
>NZ_CP038157.1|WP_144317830.1|1137221_1138013_+|pantoate--beta-alanine-ligase
MAFEPGAAVVVTDPVQLATYGRAFRKVGKSVVVVPLGEGIHAGHVQLIRAARALLGAVVMVTYSGEKVPEVFAAEKVDVVFHGCLGGGVCVSTGIDHLEDAGEIDAAVGSVIAAAGATHATDIVLGEKDFELLVALQRAVTALRMEVKLHSVPIVRASSGVAMSLRNDRLAQIDCERALALSAALTAGAHVAERGADEVLATARGVLEAAGVSHDYLQLRSLGFGPAPAQGDARLLGAITLGGVRLIDNVGVPVGVGFKNIGG
>NZ_CP038157.1|WP_144317829.1|1136513_1137221_+|hypothetical-protein
MAPRLTIGAVVTETELSRALARAGHTVRGLDARNPGSVADVDAVLLDMSDTVRIAELADAFAAYVRPRQMFIHTALAQGAQLLDAVETRGAIVMAAHNVFSNHWVTSAADELGETVIGLLIAEIGGMSHTIADSQRMRAAAALRIQAHESVLRADSFDLLSSAVESLEAFGHEYSVAPRGSVDKLSPAELERMRQAIDDPGVAALFVELQRRSAQQLGDAETELWSMFTTNQEGK
>NZ_CP038157.1|WP_144317828.1|1135505_1136513_+|hypothetical-protein
MTMNAENTKRDNATLWIVVPFALAIVGTVVMLFTNSANVLKVSLILALWAAVAGIILVTRLRRDRDQAQRELVARSERFEAELDAAQARGEADRVLLERARSGSDTASSIDVEVLREIQAELARLRAQLEELSGRYFEYEPAALRAQARRIAELEEAAGSSKVEPEPVAPEPEPVAVVAEPEPMEPEPEPESVAAKPASGPSTDDTAKLQRVRESAPAAKRTTPAPGPSRPAGAPTFDAVAGWVGERRETINDAHNPLSKLISERQAEKFEEPAQPAPKPAPKPAPKPAPEPAPKPAAEPAQKPETHGGRRRRDEHGRSSLTVAELLARAERNAE
>NZ_CP038157.1|WP_136648939.1|1135033_1135501_+|DUF3180-domain-containing-protein
MTRISIPALVALAGFMAAAVFILVRRFYGALSTIGLSASMPLWIVAAVCLFVAYMVKKRREEGKVGLDRSQLNPMMAANFMLLGKASAWAGAVCAGAFAGLLVYIAPRLDLLAAAQADLPGTLSGTLGGLALAVAGVVLERACEVSPPTQGEAVG
>NZ_CP038157.1|WP_144317827.1|1134578_1135037_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MRAVLSTGSNMEDSRAHLASVVDEFAAELVAASSLYATAPWGGVEQDDFLNQVLIVDVEQSPRELLRRCQSLEQRARRVRKKRWGPRTLDVDIVLIDGFFSRDPELTVPHPRAHERAFVLVPWLEIDPDAHLGDRSVAGIVDMLGAEGVRKL
>NZ_CP038157.1|WP_144317826.1|1134197_1134575_+|dihydroneopterin-aldolase
MADRIELKGLRIHANHGVLEHETRHGQGFSLDIVCWLDFADAAATDDLTLTVNYAELAQLAHDIAAGAPRQLIETVASEIADAALRSFEALHAVEVTVHKPHAPIPLLFDDVAVVARRSRKNLKA
>NZ_CP038157.1|WP_144317825.1|1133353_1134205_+|dihydropteroate-synthase
MTTVQELTVPGRALVMGIVNVTSDSFSDGGRWLDLDSALDHARTLVARGADIIDVGAESTRPGAVRVPAEVEAERVRPVIEHLHAEGIRTSVDTMRASTARVAAAAGVDMINDVSAGLADPDMYRVMADANVPVCLMHWRTDVFGDAAGASDHGGDVTGDVHALLNQCIDGALAAGVKRDQIVVDPGLGFAKTAHENWRLLATLPEFIAGPYPVLVGASRKRFLTAIRAERGLEHGPEDADPATAAVTAIAAQMGAWCVRVHEVAASRDAVDVAAAWNGASRG
>NZ_CP038157.1|WP_144317824.1|1132774_1133350_+|GTP-cyclohydrolase-I-FolE
MSARAFNRDRAEAAVRELLIAVGEDPDREGLAETPARVARAYEEVFAGLHSEPTDVLEKTFAENHQELVLVRDIPIYSTCEHHLVPFFGTAHIGYIPGPDGKVTGLSKLARLADLYAKRPQVQERLTGQIADALVDKLDAQAVIVVIECEHLCMAMRGIRKPGAVTTTSAVRGGFQHNAASRAEVLSLIRR
>NZ_CP038157.1|WP_144317833.1|1140811_1142821_+|PTS-glucose-transporter-subunit-IIA
MSTTTSSLSAQAKDILDGVGGADNIATLTHCATRLRFELNDASLANKAALEAVPKVMGAVPQGGSHYQVIVGGDVANVYTAMNNLPEMRERSNSAVKAQQRAKAQGKLPWLDAFFEYLSDSFRPILGVLLGASLVIAFAAVMDALGLVDFRAEVKSPGWQFVDAMWSSVFFFLPVMVAYNAGKKLGIDPWVPAAVMLALFTPNFTGLADHPDAVTTQNALLGSEVTRVDVFGLPMYLPDYNGNVFVPLIMAAIAAVVYKGLQKIIPSAVHMVFVPFFTLLVMIPLTALAIGPFGYALGAWIGTGLAFLNTNAPFVFAIAIPMLYPFLVPLGLHWPLNALMLVNIQTLGYDFIQGPMGVWNFACFGATAAVLAISMREKDNVMRQTSGSALAAGLFGGISEPSLYGIHLRYKRIYPRMLVGCFVGGVTIAILSAPFAGVQTNAFVFTSLLTISVFNPAWVYIIAIAVAFFTSFALIYISDYRTAEEKAAAREGAAQSAEPAPAAQEPAQEPAAEKPAATTRVLAPAAGEIVAMEALADPAFSAGALGQAVGVIPEAGEGTVVSPVAGTVISVAKTGHAYGIKTADGIEILVHIGIDTVKMKGEGFEPLVDKKQEVTEGTELARVNFAAVKAAGFDPTVITTVVNTKAMAGVADVADGTVGAGDPVLEVTR
>NZ_CP038157.1|WP_144317834.1|1142850_1143714_+|PRD-domain-containing-protein
MQILRVFNNNVVLARSGEHGGEVVATGRGIGFGKKQGDVLDPAAVTRVFVPAEGRDPDHSAQMLAGLPAERVAQVAAALEAVGAPADSRNRLTLVTAISDHLEFAAARAASGEELNYPLRSEVLHLYPREYEMGVELLAEINRRQRAAGATELPDSETTALALHLVNAGFSTGDLAQTYQMTGVIQQMLEIVAAGLSITLNTASISVARFITHVRYLLVRLSHGRQLDHGQSPLTRQLLDAYPREVACARQVATVVELRFDCALTEDEIAYLGLHIVRLGETQRMSQ
>NZ_CP038157.1|WP_144317835.1|1143710_1145408_+|phosphoenolpyruvate--protein-phosphotransferase
MTDRSVLHGIGVSAGTASGPAAVVTPPTGVDEAEPPSVDPEADGERVREVLEQVAASLRERAGLANSETSAAVLEATAALATDRGLIKGVARQLQKGSGPTRAIFDAVEVYAAKLRKLGGYMAERVTDLYDIRDRAIARLRGVAEPGVPALSRPSVLVAHDLAPAETATLDPALVRGIVTAGGGATSHTAILAAQLGIPAAVQVKGIDALLAGEGEVELAIDGGVGEVIVAPTPDDVAELEERSRRRAAALAGSSGEGATRDGHRVKLLANIGTAADAAQTAAADIEGSGLFRTEFLFLDREAAPSVEEQTATYAEVLRSFGTRRVVVRTLDAGADKPLSFADLGPEDNPALGRRGLRLSQAREDLLDAQLSALAAAHKLVPEADLWVMAPMVTTVEETQWFAEKTRAHGLPRVGVMVETPAAAVRAKHLLALVDFASIGTNDLSQYTMAADRMEGELAHLLNPWQPAVLSMVRATCRGGEATGKPVGVCGEAGGDPLLALVLVGLGVTSLSMAPSRVGAVRAALRSHDIDTCRQMANFAEDAPTAADARAAVLALADPVLRDLL
>NZ_CP038157.1|WP_136648930.1|1145568_1148307_+|ATP-dependent-Clp-protease-ATP-binding-subunit
MFERFTDRARRVIVLAQEEARALNHNYMGTEHILLGLIKEGEGVAAKALESMGINLEDVRREVEELIGHGTQPVTGYIPFTPRAKKVLELSLREGLQMGHKYIGTEFLLLGLIREGEGVAAQVLIKLGADLPRVRQQVIQLLSGYEGGEGQGEGGEQGGLAGAGSGPAAFGGGGGSRGGQQGERSNSLVLDQFGRNLTAAAREGKLDPVVGRDKEIERIMQVLSRRTKNNPVLIGEPGVGKTAVVEGLALDIANGKVPETLKDKQVYSLDLGSLVAGSRYRGDFEERLKKVLKEINQRGDIILFIDEIHTLVGAGAAEGAIDAASLLKPKLARGELQTIGATTLDEYRKHIEKDAALERRFQPVQVDEPSVEDTVTILKGLRDRYEAHHRVSYTDDALVAAANLSDRYINDRFLPDKAVDLLDEAGARMRIKRMTAPEGLREVDERIAEVRKEKEAAIDAQDFEKAAGLRDTERKLGEERREKEKQWRSGDLEEIAEVGEEQIADVLANWTGIPVFKLTESESSRLLNMEDELHKRIIGQDEAVRAVSRSIRRTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALAEFLFGDDDSLIQVDMGEFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHKEIYNTLLQVLEEGHVTDGQGRLVDFKNTVLIFTSNLGTSDISKAVGLGFSGSTATDSEAQYDRMKNKVHDELKKHFRPEFLNRIDEVVVFRQLSQDEIVQMVELMIARVDKNLAAQDMGIEVTDKAKDLLALRGFDPVLGARPLRRTIQREIEDILSEKILYGEIGAGEIITVDVENWDGDVEAAKRERGKVAEEATFTFTPRPKPLPAETFDVELEDEVRDISPTDGEADALVPDVPPETEGSEDDGGATPPPAGAGQPL
>NZ_CP038157.1|WP_144317836.1|1148303_1149659_-|lipase
MKHLLKLTAATTCAALALTTASVTASITTANAQSSGEAQKLADGVHHAATTPADSFIHGYDPFYDDPVDNLGTPGTLLRTQPAPHLLNILGPDFPGYAEKILYTSTTVHGDPVATSGFVIEPANPWQGNGPTPTVIFAPGTRGAGDMCAPSRGPWLTAQLDAAQPALGVNYELVFYEAAALAGMRVVVVDYIGLGTPGAHTYVLHDEEGHAMLDAARAVVPAGSPVAFYGYSQGGGASAAAAELQPTYAPELNVKGTFAGAPPADLMEVVKGVDTSTITSVLGYAANGYLARYPELGAVLDAKLNDRGWEFLNGTKGSCMVDDALTRHFTSTSDLTSTGESLYEIVNSLPHIKQLFVDQKLGETAPTSPIMVSTGGNDDLVPTPQVVQLARDYCALGVTTTMFNENIPPLTPGTKFGVNHAAGIITQSPTSFRWIMDRFNGVPAGSNCGTF
>NZ_CP038157.1|WP_136648928.1|1149749_1150529_-|zinc-transporter-ZupT
MAVAFAITLLAGASTGFGGLLVALKSSPSNRFLAGSLGLSAGVMVYISLVELLPGGIDDLTEVYGHRAGLYGVLAFFAGVAVIAVIDRLVPESINPHEFQDEGGRYQARSAMKRAGLLTGFAIAIHNFPEGFATFVTALGDPKIALPIAFAIAVHNIPEGIAVAVPLREATGKKWTAAGWATLSGLAEPVGALVGFALLMPFMGPATLGLTFAAVAGIMVFISFDKLLPSAIATGEHHHSVYGVIAGMALMAASLVALA
>NZ_CP038157.1|WP_006840589.1|1150601_1150772_+|DUF4236-domain-containing-protein
MGLYYRKKKKLGRNSWLNLSKSGGSVSKKVGPITVNSRGGLWVNLPGGLNFRGKWK
>NZ_CP038157.1|WP_136649054.1|1150785_1151649_-|A/G-specific-adenine-glycosylase
MDMQTKVIDYFRANARDLPWRRAGTSAWGVLLSEVMSHQTPVARVAPIWQEWIRRWPTLADFAAASGDEVLRAWGSLGYPRRALRLLDCARTIVADHGGEVPRDVDTLLSLPGIGAYTARAVACFAYGANVAVVDTNVRRVYARAVEGRFLAQPRAGEIADVAALLPAQDGPVFSAGLMELGALVCTATNPECGSCPLERQCAWVAAGKPAPSEAELKRRKVQKFAGTDRQVRGKIMKVLREAPGPVAQERIDVVWPDAAQLSRALFSLLDDGLATQNADGTFRLPS
>NZ_CP038157.1|WP_136648927.1|1151671_1152292_+|carbonic-anhydrase
MTEPTTATPADVWEHMLAGNDRFATDNVEHPNSTVERRLELREGQAPVAAVLACSDSRVPVELLFDAGLGDMFVIRTAGGCVDAAVSGSVDFAVTSLGVKLVIVLTHEACGAIGAALTAVENAEIPLGLQRVFVEKIAPSVIWSKGHGKTGRNDIEREHARITAQHLVDRIPALQDGTADGSIGVVAARYSLADGRVETVATHFAR
>NZ_CP038157.1|WP_136648926.1|1152303_1153017_+|hypothetical-protein
MNNQPHQNPDSRPLPPEIYMRRRVAALVILLVLVALLVWGLTAWARSGSDAGEATESTAPATPTEQITTEPTVPAPSDEETTASTTTTTEATTTSDTATPTVNAAGKGTCELADLEIEAQTSEPSYAAGDQPVFYMKINNPTKAECGINLDDNQLRFEVYTMSDNQRVWSDVDCYPPVVTGEETFKPGEPRMFEARWSATGSKPGQCTNRQPVAPGAYYLHAVVGDSASNPADFTIR

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Crispr_ID: NZ_CP038157_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_6

1614917-1615022

Orphan

Consensus_repeat	Method
CTGGGCTTTTGTGTGGGGCGGTGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP038157_6

>merge|NZ_CP038157|6|1614917-1615022|CRISPRCasFinder
CTGGGCTTTTGTGTGGGGCGGTGCGCTCAGGTCTAGTAGCTATACTTCAGCGGTGTGGGTGCCACACGCGTCACAGGTGTGCTGGGCTTTTGTGTGGAGCGGTGCG

>NZ_CP038157|6|4|1614917-1615022|CRISPRCasFinder
CTGGGCTTTTGTGTGGGGCGGTGCG	CTCAGGTCTAGTAGCTATACTTCAGCGGTGTGGGTGCCACACGCGTCACAGGTGTG
CTGGGCTTTTGTGTGGAGCGGTGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_136651550.1\|1614488_1614842_+\|phosphoribosyl-AMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234598
NZ_CP038157.1\|WP_136651545.1\|1609943_1610132_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_136651555.1\|1618114_1619536_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|180487
NZ_CP038157.1\|WP_144318104.1\|1612910_1613702_+\|inositol-monophosphatase-family-protein	unknown	unknown	gnl\|CDD\|238815
NZ_CP038157.1\|WP_144318625.1\|1613718_1614492_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	unknown	unknown	gnl\|CDD\|234996
NZ_CP038157.1\|WP_144318105.1\|1615137_1615359_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144318102.1\|1611460_1612111_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|237290
NZ_CP038157.1\|WP_144318108.1\|1621693_1623586_-\|aminodeoxychorismate-synthase-component-I	unknown	unknown	gnl\|CDD\|223225
NZ_CP038157.1\|WP_144318626.1\|1617117_1618089_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|237284
NZ_CP038157.1\|WP_144318107.1\|1620989_1621697_-\|aminotransferase-class-IV	unknown	unknown	gnl\|CDD\|376449
NZ_CP038157.1\|WP_136651556.1\|1619612_1620794_-\|glutathione-dependent-formaldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|176243
NZ_CP038157.1\|WP_144318100.1\|1609338_1609941_+\|imidazoleglycerol-phosphate-dehydratase-HisB	unknown	unknown	gnl\|CDD\|234873
NZ_CP038157.1\|WP_144318101.1\|1610135_1611449_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
NZ_CP038157.1\|WP_136651553.1\|1616222_1617074_+\|indole-3-glycerol-phosphate-synthase	unknown	unknown	gnl\|CDD\|223212
NZ_CP038157.1\|WP_170228654.1\|1608227_1609358_+\|histidinol-phosphate-transaminase	unknown	unknown	gnl\|CDD\|235115
NZ_CP038157.1\|WP_136651543.1\|1606908_1608213_+\|histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|234853
NZ_CP038157.1\|WP_144318106.1\|1615498_1616179_+\|TIGR02234-family-membrane-protein	unknown	unknown	gnl\|CDD\|378200
NZ_CP038157.1\|WP_144318103.1\|1612122_1612866_+\|bifunctional-1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase/phosphoribosylanthranilate-isomerase-PriA	unknown	unknown	gnl\|CDD\|237589
NZ_CP038157.1\|WP_144318109.1\|1623826_1624129_+\|urease-subunit-gamma	unknown	unknown	gnl\|CDD\|183913
NZ_CP038157.1\|WP_144318110.1\|1624138_1624549_+\|urease-subunit-beta	unknown	unknown	gnl\|CDD\|238238

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_136651550.1\|1614488_1614842_+\|phosphoribosyl-AMP-cyclohydrolase	gnl\|CDD\|234598	PRK00051, hisI, phosphoribosyl-AMP cyclohydrolase; Reviewed.	7.22941e-64
NZ_CP038157.1\|WP_136651556.1\|1619612_1620794_-\|glutathione-dependent-formaldehyde-dehydrogenase	gnl\|CDD\|176243	cd08283, FDH_like_1, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1. Members identified as glutathione-dependent formaldehyde dehydrogenase(FDH), a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD(P) to formate and NAD(P)H. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. MDH family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. Like many zinc-dependent alcohol dehydrogenases (ADH) of the medium chain alcohol dehydrogenase/reductase family (MDR), these FDHs form dimers, with 4 zinc ions per dimer. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NZ_CP038157.1\|WP_136651555.1\|1618114_1619536_+\|pyruvate-kinase	gnl\|CDD\|180487	PRK06247, PRK06247, pyruvate kinase; Provisional.	0
NZ_CP038157.1\|WP_144318104.1\|1612910_1613702_+\|inositol-monophosphatase-family-protein	gnl\|CDD\|238815	cd01637, IMPase_like, Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-bisphosphate, inositol poly- and monophosphates, PAP and PAPS, sedoheptulose-1,7-bisphosphate and probably others.	8.25439e-55
NZ_CP038157.1\|WP_144318625.1\|1613718_1614492_+\|imidazole-glycerol-phosphate-synthase-subunit-HisF	gnl\|CDD\|234996	PRK02083, PRK02083, imidazole glycerol phosphate synthase subunit HisF; Provisional.	2.22097e-161
NZ_CP038157.1\|WP_144318108.1\|1621693_1623586_-\|aminodeoxychorismate-synthase-component-I	gnl\|CDD\|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	5.09251e-138
NZ_CP038157.1\|WP_144318102.1\|1611460_1612111_+\|imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|237290	PRK13146, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	5.40816e-108
NZ_CP038157.1\|WP_144318626.1\|1617117_1618089_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	8.90126e-115
NZ_CP038157.1\|WP_144318107.1\|1620989_1621697_-\|aminotransferase-class-IV	gnl\|CDD\|376449	pfam01063, Aminotran_4, Amino-transferase class IV. The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.	7.5613e-15
NZ_CP038157.1\|WP_144318100.1\|1609338_1609941_+\|imidazoleglycerol-phosphate-dehydratase-HisB	gnl\|CDD\|234873	PRK00951, hisB, imidazoleglycerol-phosphate dehydratase HisB.	7.35944e-114
NZ_CP038157.1\|WP_144318101.1\|1610135_1611449_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.69742e-57
NZ_CP038157.1\|WP_136651553.1\|1616222_1617074_+\|indole-3-glycerol-phosphate-synthase	gnl\|CDD\|223212	COG0134, TrpC, Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism].	3.64972e-66
NZ_CP038157.1\|WP_170228654.1\|1608227_1609358_+\|histidinol-phosphate-transaminase	gnl\|CDD\|235115	PRK03317, PRK03317, histidinol-phosphate aminotransferase; Provisional.	0
NZ_CP038157.1\|WP_136651543.1\|1606908_1608213_+\|histidinol-dehydrogenase	gnl\|CDD\|234853	PRK00877, hisD, bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Reviewed.	0
NZ_CP038157.1\|WP_144318106.1\|1615498_1616179_+\|TIGR02234-family-membrane-protein	gnl\|CDD\|378200	pfam09534, Trp_oprn_chp, Tryptophan-associated transmembrane protein (Trp_oprn_chp). Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	5.52615e-26
NZ_CP038157.1\|WP_144318103.1\|1612122_1612866_+\|bifunctional-1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase/phosphoribosylanthranilate-isomerase-PriA	gnl\|CDD\|237589	PRK14024, PRK14024, phosphoribosyl isomerase A; Provisional.	9.1705e-140
NZ_CP038157.1\|WP_144318109.1\|1623826_1624129_+\|urease-subunit-gamma	gnl\|CDD\|183913	PRK13241, ureA, urease subunit gamma; Provisional.	2.43558e-67
NZ_CP038157.1\|WP_144318110.1\|1624138_1624549_+\|urease-subunit-beta	gnl\|CDD\|238238	cd00407, Urease_beta, Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of external and internally-generated urea as a nitrogen source. The enzyme consists of three subunits, alpha, beta and gamma, which can exist as separate proteins or can be fused on a single protein chain. The alpha-beta-gamma heterotrimer forms multimers, mainly trimers. The large alpha subunit is the catalytic domain containing an active site with a bi-nickel center complexed by a carbamylated lysine. The beta and gamma subunits play a role in subunit association to form the higher order trimers.	1.96983e-62

>NZ_CP038157.1|WP_136651550.1|1614488_1614842_+|phosphoribosyl-AMP-cyclohydrolase
MTNPAEYTLDPAIAARLKRNSAGLVPAIVQAHGTGEVLMMAWMDDHALAHTLATRQGTYYSRSRDEYWIKGLTSGNTQEVTGVRLDCDGDTLLVTVKQVGGACHTGDRTCFDADALL
>NZ_CP038157.1|WP_144318625.1|1613718_1614492_+|imidazole-glycerol-phosphate-synthase-subunit-HisF
MGVAIRVIPCLDVDNGRVVKGVNFENLCDAGDPVELAKRYGEEGADELTFLDVTASTAGRGTMLDVVRRTAEQVFIPLTVGGGVRSVDDVRELLRAGADKVSVNTAAIANPGLIRELAERFGAQCVVLSVDARCVPEGGTPQPSGFEVTTHGGTRSAGIDAIEWARRGEELGAGEILLNSMDGDGTKAGFDIGLIEKVRAAVTVPVIASGGAGEAAHFPPAVSAGADAVLAASIFHFGEVSISSVKDSLRAAGRDVR
>NZ_CP038157.1|WP_144318104.1|1612910_1613702_+|inositol-monophosphatase-family-protein
MDSNEHYLEIAESVVDEARELFISHLGAAPALFKASGDFATEADLAIEKLMRSRLTRETGIPVYGEEQGGDLNSSACWVVDPIDGTSNYSSGNPNCSILVSLILNGQPVVAVTDIPLMNMRLTGVDGSPVYLNGQELPPIGTDTTAASQVGVGSVRSPDSERFPADVRLNMIATLADTDLRPRISGSVGVDFAFVAQGIYQAAVSFSPHLWDNSAGILLSRCAGAVVTGPDGEPWTMDAVGVIAGTRRAHKIALSTMRSVSSK
>NZ_CP038157.1|WP_144318103.1|1612122_1612866_+|bifunctional-1-(5-phosphoribosyl)-5-((5--phosphoribosylamino)methylideneamino)imidazole-4--carboxamide-isomerase/phosphoribosylanthranilate-isomerase-PriA
MSFTLLPAVDVVNGQAVRLDQGEAGTEKSYGSPLEAAERWRDEGAQWLHFVDLDAAFGRGSNHELMAEITRNLGIAVELTGGIRDDASLERALATGAKRVNIGTAALNNPQWTADAIKRHGDAIAIDIAVREEDGQWRTKGHGWTSDGGDLWEVVEFFDAAGCARFVVTDVSRDGTLTGPNVDLLRDVSAATDAFVTASGGVSSISDVLEIAQFAQEGIDSVIIGKALYEHKFTLREALDALGRSES
>NZ_CP038157.1|WP_144318102.1|1611460_1612111_+|imidazole-glycerol-phosphate-synthase-subunit-HisH
MTQPTSPSVVLLDYGAGNIRSAQRALEHVGASVTVTDDPKLAVDADGLVVPGVGAFASCMEGLRAVNAPRVIGQRLAGSRPVLGICVGFQVLFERGVEHGVDASGIGEWPGVVDKLQAKVLPHMGWNTVDIAPGSELFAGLDPETRFYFVHSYGVRSWEMQPDEFIAAPAVSWSEHGGDRFVAAVENGPLWATQFHPEKSGEAGLALLRNWVRTLR
>NZ_CP038157.1|WP_144318101.1|1610135_1611449_+|MFS-transporter
MIRARWSQVLTTEEVNAITSPWKARGLVPTLIAVAAAFGAWSLLLPVVPTAVLDAGGSETLAGGSTGAFMAATVITQILVPKLLRRFGYRAVIAVASLLLGLPALGYALGMDPVIVITVSVIRGIGFGALSVAEAAIITELVPLRLLGRTAGIFGLSVGFSQMVALPSGLALADRVGYEPVYVLAAAIGLIGLVVCVRIPTIPAADPTTADLSSVRVPLWRLVAVPMIALALVTTAYGAVTNFLPISVRELDPTAGAAFGGVLLAVMNFAAMFSRYYAGAVLDRRGVPGTVLIPFQVSAAAGIFIIAAVIWAEASVWWLLLAALLYGAGFGAVQNESLTMLFYRLPKSKASEASAMWNVAFDSGTGLGSTVYGMMLTSMTMAPMFGVAGVVVAVGIAVTVADLVLGRNRVAEVNNLAVRLKSVRAPGRDRGYKRPGR
>NZ_CP038157.1|WP_136651545.1|1609943_1610132_+|hypothetical-protein
MPQEFSVASGMWVLISFLIAGLLLGGVWSAYQSGSKVATVVLAIAAAVALCVAVLSMLGAVG
>NZ_CP038157.1|WP_144318100.1|1609338_1609941_+|imidazoleglycerol-phosphate-dehydratase-HisB
MSQRLGSASRTTSESNITVEINLDGSGKTDISTGLPFFDHMLTAFGTHGAFDLAVKAEGDTHIDAHHTVEDTAITLGWALADAVGDKQGIRRFGSALLPMDETLVESVVDFSGRPYFVMNGEPDHLQWQIIGGHYATVINRHFFETLAYNARVTLHVNVRYGRDPHHITEAEYKAVARALRQATERDGRITGVPSTKGAL
>NZ_CP038157.1|WP_170228654.1|1608227_1609358_+|histidinol-phosphate-transaminase
MDFLDNTIAADTAIDALPLRGELRGKQAYGAPQIDVAVALNTNENPYPPSQELIDDLVAEITKFGPTLNRYPERDAVELRTDLAAYVTRQTGVAVTRDNLWAANGSNEVLQQLLQAFGGPGRTAMGFTPSYSMHPILSSGTQTEFIGVERGPDFRIDMDTALQAIAEHQPDIVFVTTPNNPTGDVTSLAAIERIIDAAPGIVIVDEAYAEFSPSPSAVSLVERYPTKLVVSRTMSKAFDFAGARLGYFVAAPAFIEAVMLVRLPYHLSVLTQAAARVALRHGAETLAGVDKLARERERVQAALLEMGYSVVPSESNFLFFGHFDDAHEAWEKFLGYGVLIRDVGVAGHLRVTIGLDEENNQFLAAAKEIINESAAR
>NZ_CP038157.1|WP_136651543.1|1606908_1608213_+|histidinol-dehydrogenase
MLHVTDLRGRTPSTSELRRALPRGGVDVTAVLPTVAPIVEDVKKRGATAALEYGEKFDRIRPESVRVPAERIDAALANLDPAVREALEVAIGRIRTVHAAQKPSTSTIELAPGATVTEKFIPIARVGLYVPGGKAVYPSSVLMNVIPAQEAGATSMVVCTPPQEEFGGWPHPTTLAACSLLGVTEVWAVGGAQAIALLAYGDDEFGLEPVDMVTGPGNVFVAAAKRLVNGVVGIDSEAGPSEIAVLADDTANATFVAYDLISQAEHDENAASVLITPSEELANAVRAEVERLAGQTLNAQRAASALGGRQSGIVLVDDLETAIAVTDAYASEHTEVHTENPRAVAERLTNAGAIFVGPYSPVPLGDYAAGSNHVLPTSGTARFAAGLSTHTFLKPVNLIEYDEAALKEIGSHIVVLAADEQLPAHGEAIKARGI
>NZ_CP038157.1|WP_144318105.1|1615137_1615359_-|hypothetical-protein
MTEVDRSTPSTWAVVGAILAVGMFLLLLLYLGLSRYFNAQELKTLVDGAEAAGQSYSVIIYNGLTGRYSFKAG
>NZ_CP038157.1|WP_144318106.1|1615498_1616179_+|TIGR02234-family-membrane-protein
MAQQTADRGASRIGAAGIGVGGIIVAAFSRAPWMQVSYFDDRVGGGVRALSGAQWSTEASAVALLLLAAAVAALALRRLPRRIIGAIAAVAAVGAALSPLNLLVSGADPERVRALLTAGAEEAQAREGTISAMAEITSIQVNPAYLVLTLLGFLLAAAGGAVVAARPGVDSAKLNKYETEAVRRQKIGSDLEENPDSGRVLWDALDADIDPTDPAGGVGEGVDKRR
>NZ_CP038157.1|WP_136651553.1|1616222_1617074_+|indole-3-glycerol-phosphate-synthase
MRSGRETVMHTAKVANGVVAAVLRDVEKREAVVPFQDIKARSREMEPTRDVRAALLRHGCGVIVEIKRNSPVFGPTAPFAQSETPVEDVARAIEAGGAHLIACQTERLRFDGSLTDMANARDAVDLPMVCRDVIVDPYQIHEARCFGADMIPLQVGILDQNRLEALIDRAESLGMVVMAEVRTGEEADRALCAGATVIAVNSWTFDTNSLNPAAFAEIAPGLPSAVIKISLGGVRTARDLIDAASSGADAVLAAEAVMSSDDVTAATRRLAAAGQHPACPSRS
>NZ_CP038157.1|WP_144318626.1|1617117_1618089_+|prolipoprotein-diacylglyceryl-transferase
MGVETMILANIPSPPQGVWHIGPVPIRAYSLCIITGIIIALWLTLKRYKARGGDPDVVWDAAIVAIPAGIIGGRLYHVITDYDKYFGPGRDPWQAFNVAGGGLGILGAVALGTLAVWALFRYKKVPLAPFADAVAPTIILAQAIGRLGNWFNQELYGRPTDVPWALDIYYRVDEAGNYAPLTGRSTGEIVASVHPTFLYELVWNLAVFAFLLWAERAWRLGHGRVFAFYLAGYALGRFFVELMRADEANLILGLRVNTWVSGILFVVALIIFLRLPRGQETPDEVDPRNDREGEPASADSDSANLPATRYGGEAHDGSKPRTY
>NZ_CP038157.1|WP_136651555.1|1618114_1619536_+|pyruvate-kinase
MDRRTKIVCTLGPAVASKEAIVGLVRDGMNVARLNFSHGDHADHERNYRWVREATDETGHAVGILADLQGPKIRLGRFEEGSTQWDTGEEVRITVEDVVGTHDRVSTTYKQLAEDAKPGDRLLVDDGKVALVVTEVDGNDVVARVTEGGPVSNNKGVSLPGMNISVPALSEKDIDDLKFALNLGVDFIALSFVRSPSDVDLVHEVMDEVGRRVPVIAKLEKPEAVDALESIILAFDAVMVARGDLGVEIPLEQVPLVQKRVIQIARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADAVMLSGETSVGVDPHNVVRTMSRIVRVAESMGTVPPLNHIPRTKRGVIAYSAHDIATRLNARAIVTFTKSGDTARRVARLHPDHPLLVFTPVQQVRSQLALTWGAETFLCPQTNGTDEMVRLVDEYLLSIGTYSKGDTMVIVAGTPPGVSGTTNTIHVHQLGEDTRNP
>NZ_CP038157.1|WP_136651556.1|1619612_1620794_-|glutathione-dependent-formaldehyde-dehydrogenase
MKALTWQGAGKVSVETVDDPTIEKPTDAIIEVTSSGVCGSDLHLISVLAPYMNEGDIMGHEPMGRVVEAGSASGLKVGDRIVVPFNISCGHCWMCDHSLYSQCETTQVTEKGSGASLLGFSELYGSVPGGQAQYLRVPHADFGAIKVGNELEDHRYVFLSDVLPTAWQGVKYADVGEGDTIAVYGLGPIGQMAARMARHMGARVFGIDPVAERREMAARHGIEVFAGGDETVAELRDMTDGRGPDAVLDAVGMEAHGSPVGGAIQTAAGFLPDAAAQKVMETAGVDRLSALHEAIDLVRRGGTISISGVYGGAASPMPLLTLFDKQIQMRMGQCNVKKWISDLMPLVEDPSDPLGVDDLVTHRVPLSEAPEAYKKFRDKEDNCIKVVLDPVAG
>NZ_CP038157.1|WP_144318107.1|1620989_1621697_-|aminotransferase-class-IV
MTSYVWQGRWVPTRDTPQGFDCADSWRHEYGRARGLELHRMRFAAGVGPLPAGMWESALALLDASADLFPRISVYEERFRLDIRPAPPVRESTDLTLVSAPDPRTMPLLKGPDLMRLAEHRRAHAIAGTDDVILGDFAETTTGTLVGWNGRTLVLPEATRLPSTTEALVVERAKKLGCDVAHGVLDPAKPMWFLNALHGISPVRRIVSHTAVVLLPRSPGESEWHSWWRYKQLDF
>NZ_CP038157.1|WP_144318108.1|1621693_1623586_-|aminodeoxychorismate-synthase-component-I
MILLIDNRDSYTFNLAHLIAKVSGSEPVVVRADDVTVLDLPRRIKAGEFSHIVISPGPGTPSCEADFVGSRAVIEAAGGIPVLGVCLGHQGLAHLAGAEVGRTDPRHGYTSTITHSGEGIFAGLPQGFTAVRYHSLHIDNVPDGVVVHARSEDGVVQGLEVAGQPHWGVQFHPESVLTEYGAELLRNFLALGAWRVHHECVGEAIDTEATARALMGSSGDAFWLDSATGDGFSIIGSTAGSLSKTLSYRLTDPGPDVLSLLADELSAGVAASTLPDLPFRGGWVGFIGYECAALTLPGLSPTHARAHPDAYFIRPQSFIVYDHVQERAHLMVCARGDEKTAEVEHLMAALRNAVTTRSAHRGRASISEGSWRLAGGEYDARFGEVKRALERGDSYEVCLTDTYEARVAGEGIDLYSRLRRTNPAPFGAYLRLGGIEVLSSSPERFLRVRGDRVETKPIKGTLPRERRAQELQEDAKTRAENLMIVDLLRNDLARVSVPGTVDVAQLMTVETYATVHQLVSTITGRLRPDRGLIDLVRATFPPGSMTGAPKERTCALIDALEPGPRGVYSGAIGYFGFDGNAELSVVIRTAVKQGERLTVGAGGAIVWDSRADAEYTELQLKANAVIAGLT
>NZ_CP038157.1|WP_144318109.1|1623826_1624129_+|urease-subunit-gamma
MYMVPRDKEKLLIVVAADLARRRQARGLKLNYPEATAIITYELLEGARDGRSVAELMNWGTTILTRDDVMEGVPEMIESVQVEATFPDGTKLVTVHNPIR
>NZ_CP038157.1|WP_144318110.1|1624138_1624549_+|urease-subunit-beta
MRPGEYVLASEPIECNAGREAIELEVTNTGDRPVQVGSHYHFAEINPCVVFDRDRTLGHRLDIPAGTAVRLEPGDTRTVRLIALGGKRKVYGFHNLVNGPLDVRKPARVNVMGEAGYGFAEYGADLSDPKIVDKEA

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Crispr_ID: NZ_CP038157_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_7

1842735-1843271

Orphan

Consensus_repeat	Method
GACTCCGCATTGCGGACT	CRT
CTCCGCATTGCGGACTTTGCGGGCGAG	CRISPRCasFinder
CTCCGCATTGCGGACTTTGCGGGCGAG	CRISPRCasFinder
GGCGACTCCGCATTGCGGACTGTAAACGCCGCGCTCCAAACCTGG	PILER-CR

11 spacers

The CRISPR arrays of NZ_CP038157_7

>merge|NZ_CP038157|7|1842735-1843271|CRT,CRISPRCasFinder,CRISPRCasFinder,PILER-CR
GAGTCCGCATTGCGGACTCTGAACGTATTGCTCTGAACCCGGGGACTCCGCATGGCGGACTCTGCGGGTCGCGCTTCAAGTCGTGGGGACTCCGCATTGCGGACTGTAAACGCCGCGCTCCAAACCGGGGGGCTCCGCATTGCGGACTTTGCGGGCGAGTTTAGGGTAAAGCCTGGCTAGTTATGAGTCCGCATTGCGGACTGAGTGGGCCGACTTGGGGCGTGACTTGGTTTGCGGCGACTCCGCATTGCGGACTTTGCGGGCGAGCTTCAAGTCGTGGGGACTCCGCATTGCGGATTGTAAACGCCGCGCTTCATCCCTGGGGGCTCCGCATTGCGGACTTTGCGGGCGAGTTTAGGGTAAAGCCTGGCTAGTTATGAGTCCGCATTGCGGACTGAGTGGGCCGACTTGGGGCGTGACTTGGTTTGCGGCGACTCCGCATTCCGGACTTTGAGCACCGCGCTTCATCTCTAGGCGACTCCGCATTGCGGACTGTAAACGCCGCGCTCCAAACCTGGCGCCCCCACATCGCGGACA

>NZ_CP038157|7|1|1842735-1843271|CRT
GAGTCCGCATTGCGGACT	CTGAACGTATTGCTCTGAACCCGGG
GACTCCGCATGGCGGACT	CTGCGGGTCGCGCTTCAAGTCGTGGG
GACTCCGCATTGCGGACT	GTAAACGCCGCGCTCCAAACCGGGG
GGCTCCGCATTGCGGACT	TTGCGGGCGAGTTTAGGGTAAAGCCTGGCTAGTTAT
GAGTCCGCATTGCGGACT	GAGTGGGCCGACTTGGGGCGTGACTTGGTTTGCGGC
GACTCCGCATTGCGGACT	TTGCGGGCGAGCTTCAAGTCGTGGG
GACTCCGCATTGCGGATT	GTAAACGCCGCGCTTCATCCCTGGG
GGCTCCGCATTGCGGACT	TTGCGGGCGAGTTTAGGGTAAAGCCTGGCTAGTTAT
GAGTCCGCATTGCGGACT	GAGTGGGCCGACTTGGGGCGTGACTTGGTTTGCGGC
GACTCCGCATTCCGGACT	TTGAGCACCGCGCTTCATCTCTAGGC
GACTCCGCATTGCGGACT	GTAAACGCCGCGCTCCAAACCTGGC
GCCCCCACATCGCGGACA

>NZ_CP038157|7|5|1842780-1842851|CRISPRCasFinder
CTCCGCATGGCGGACTCTGCGGGTCGC	GCTTCAAGTCGTGGGGA
CTCCGCATTGCGGACTGTAAACGCCGCGCTCCAAACCGGGGGGCTCCGCATTGCGGACTTTGCGGGCGAGTTTAGGGTAAAGCCTGGCTAGTTATGAGTCCGCATTGCGGACTGAGTGGGCCGA	CTTGGGGCGTGACTTGGTTTGCGGCGA
CTCCGCATTGCGGACTTTGCGGGCGAG	CTTCAAGTCGTGGGGACTCCGCATTGCGGATTGTAAACGCCGCGCTTCATCCCTGGGGG
CTCCGCATTGCGGACTTTGCGGGCGAG	TTTAGGGTAAAGCCTGGCTAGTTATGA
GTCCGCATTGCGGACTGAGTGGGCCGA	CTTGGGGCGTGACTTGGTTTGCGGCGA
CTCCGCATTCCGGACTTTGAGCACCGC	GCTTCATCTCTAGGCGA


>NZ_CP038157|7|6|1842921-1843239|CRISPRCasFinder
	GCTTCAAGTCGTGGGGA
CTCCGCATTGCGGACTGTAAACGCCGCGCTCCAAACCGGGGGGCTCCGCATTGCGGACTTTGCGGGCGAGTTTAGGGTAAAGCCTGGCTAGTTATGAGTCCGCATTGCGGACTGAGTGGGCCGA	CTTGGGGCGTGACTTGGTTTGCGGCGA
CTCCGCATTGCGGACTTTGCGGGCGAG	CTTCAAGTCGTGGGGACTCCGCATTGCGGATTGTAAACGCCGCGCTTCATCCCTGGGGG
CTCCGCATTGCGGACTTTGCGGGCGAG	TTTAGGGTAAAGCCTGGCTAGTTATGA
GTCCGCATTGCGGACTGAGTGGGCCGA	CTTGGGGCGTGACTTGGTTTGCGGCGA
CTCCGCATTCCGGACTTTGAGCACCGC	GCTTCATCTCTAGGCGA
CTCCGCATTGCGGACTGTAAACGCCGC

>NZ_CP038157|7|3|1843013-1843252|PILER-CR
GGGGACTCCGCATTGCGGATTGTAAACGCCGCGCTTCATCCCTGG	GGGCTCCGCATTGCGGACTTTGCGGGCGAGTTTAGGGTAAAGCCTGGCTAGT
TATGAGTCCGCATTGCGGACTGAGTGGGCCGACTTGGGGCGTGAC	TTGGTTTGCGGCGACTCCGCATTCCGGACTTTGAGCACCGCGCTTCATCTCTAGGCGACTCCGCATTGCGGACTGT
AAACGCCGCGCTCCAAACCTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_144318219.1\|1853527_1854118_+\|guanylate-kinase	unknown	unknown	gnl\|CDD\|234719
NZ_CP038157.1\|WP_144318218.1\|1852158_1852968_+\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234651
NZ_CP038157.1\|WP_136651206.1\|1844857_1845424_+\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	unknown	unknown	gnl\|CDD\|235365
NZ_CP038157.1\|WP_136651212.1\|1853200_1853524_+\|integration-host-factor	unknown	unknown	unknown
NZ_CP038157.1\|WP_136651202.1\|1839882_1840881_+\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380535
NZ_CP038157.1\|WP_144318211.1\|1838028_1838595_+\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|234686
NZ_CP038157.1\|WP_144318213.1\|1843319_1844654_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|187553
NZ_CP038157.1\|WP_144318210.1\|1836304_1837396_+\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|238525
NZ_CP038157.1\|WP_144318215.1\|1846340_1847624_+\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
NZ_CP038157.1\|WP_136651201.1\|1839525_1839780_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144318217.1\|1848816_1852158_+\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NZ_CP038157.1\|WP_144318214.1\|1845420_1846344_+\|aspartate-carbamoyltransferase-catalytic-subunit	unknown	unknown	gnl\|CDD\|234849
NZ_CP038157.1\|WP_144318216.1\|1847642_1848794_+\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NZ_CP038157.1\|WP_170228699.1\|1854146_1854455_+\|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl\|CDD\|234744
NZ_CP038157.1\|WP_136651200.1\|1838608_1839460_+\|PPK2-family-polyphosphate--nucleotide-phosphotransferase	unknown	unknown	gnl\|CDD\|274737
NZ_CP038157.1\|WP_136651196.1\|1834825_1835875_+\|3-dehydroquinate-synthase	unknown	unknown	gnl\|CDD\|234565
NZ_CP038157.1\|WP_144318212.1\|1841931_1842690_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP038157.1\|WP_136651203.1\|1840877_1841924_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093
NZ_CP038157.1\|WP_136651197.1\|1835871_1836318_+\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443
NZ_CP038157.1\|WP_006840229.1\|1837465_1838029_+\|elongation-factor-P	unknown	unknown	gnl\|CDD\|234788

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_144318219.1\|1853527_1854118_+\|guanylate-kinase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	1.14092e-98
NZ_CP038157.1\|WP_136651206.1\|1844857_1845424_+\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	9.74506e-91
NZ_CP038157.1\|WP_136651202.1\|1839882_1840881_+\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380535	cd06312, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	3.99621e-93
NZ_CP038157.1\|WP_144318211.1\|1838028_1838595_+\|transcription-antitermination-factor-NusB	gnl\|CDD\|234686	PRK00202, nusB, transcription antitermination factor NusB.	4.69877e-31
NZ_CP038157.1\|WP_144318213.1\|1843319_1844654_-\|TIGR01777-family-protein	gnl\|CDD\|187553	cd05242, SDR_a8, atypical (a) SDRs, subgroup 8. This subgroup contains atypical SDRs of unknown function. Proteins in this subgroup have a glycine-rich NAD(P)-binding motif consensus that resembles that of the extended SDRs, (GXXGXXG or GGXGXXG), but lacks the characteristic active site residues of the SDRs. A Cys often replaces the usual Lys of the YXXXK active site motif, while the upstream Ser is generally present and Arg replaces the usual Asn. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.58351e-102
NZ_CP038157.1\|WP_144318210.1\|1836304_1837396_+\|M24-family-metallopeptidase	gnl\|CDD\|238525	cd01092, APP-like, Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.	6.608e-107
NZ_CP038157.1\|WP_144318215.1\|1846340_1847624_+\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
NZ_CP038157.1\|WP_144318218.1\|1852158_1852968_+\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234651	PRK00125, pyrF, orotidine 5'-phosphate decarboxylase; Reviewed.	6.04437e-111
NZ_CP038157.1\|WP_144318217.1\|1848816_1852158_+\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP038157.1\|WP_144318214.1\|1845420_1846344_+\|aspartate-carbamoyltransferase-catalytic-subunit	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	1.18097e-178
NZ_CP038157.1\|WP_144318216.1\|1847642_1848794_+\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NZ_CP038157.1\|WP_170228699.1\|1854146_1854455_+\|DNA-directed-RNA-polymerase-subunit-omega	gnl\|CDD\|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	2.63603e-17
NZ_CP038157.1\|WP_136651200.1\|1838608_1839460_+\|PPK2-family-polyphosphate--nucleotide-phosphotransferase	gnl\|CDD\|274737	TIGR03709, PPK2_rel_1, polyphosphate:nucleotide phosphotransferase, PPK2 family. Members of this protein family belong to the polyphosphate kinase 2 (PPK2) family, which is not related in sequence to PPK1. While PPK1 tends to act in the biosynthesis of polyphosphate, or poly(P), members of the PPK2 family tend to use the terminal phosphate of poly(P) to regenerate ATP or GTP from the corresponding nucleoside diphosphate, or ADP from AMP as is the case with polyphosphate:AMP phosphotransferase (PAP). Members of this protein family most likely transfer the terminal phosphate between poly(P) and some nucleotide, but it is not clear which. [Central intermediary metabolism, Phosphorus compounds].	3.05863e-113
NZ_CP038157.1\|WP_136651196.1\|1834825_1835875_+\|3-dehydroquinate-synthase	gnl\|CDD\|234565	PRK00002, aroB, 3-dehydroquinate synthase; Reviewed.	2.71889e-161
NZ_CP038157.1\|WP_144318212.1\|1841931_1842690_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	1.79519e-99
NZ_CP038157.1\|WP_136651203.1\|1840877_1841924_+\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	5.07737e-60
NZ_CP038157.1\|WP_136651197.1\|1835871_1836318_+\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	7.00915e-91
NZ_CP038157.1\|WP_006840229.1\|1837465_1838029_+\|elongation-factor-P	gnl\|CDD\|234788	PRK00529, PRK00529, elongation factor P; Validated.	1.16149e-108

>NZ_CP038157.1|WP_144318212.1|1841931_1842690_+|ATP-binding-cassette-domain-containing-protein
MAIIQLEDVTKSYGAFDALRGVNLEIDQGEVLCVLGDNGAGKSTLIKILSGLHQPTSGQMLLDGTPTTFSSPRDAINHGIATVYQNLAIVDSLSVWRNFFLGNEISGMLGTLKQDEMRARCDDALRELGINIPDVDVEAGNLSGGQRQVLAIARAIHFGARVVILDEPTAALGVKQSGVVLRFVAAARDRGVAVVLVTHNPHHAYLVGDRFTILKLGRQEINAERADITLEELTAQMAGGEELAALSHELER
>NZ_CP038157.1|WP_136651203.1|1840877_1841924_+|ABC-transporter-permease
MSTATTAASASDEDRLRRHSGVSALIRRPELASLLGLALVFALFMFVAPAFRSLDAVATVLYASSTLGIVALAVGLLMIGDEFDLSSGVAVTTAALAATMLNYNLHLNVWVGAVIALGISLAIGALNGVLVTRTGIPSFLITLAAFLMLQGLNLAVTKLVTGQVATPSISNMAGFDSARAVFASSFSIGGVSIRITVVWWLLFVAVASFVLFRTTFGNWIFAVGGNQDAARASGVPVARVKIILFMTVAFAAWFVGMHTLFAFDSIQAGQGVGNEFLYIIAAVIGGCSMNGGRGTAIGTAIGALIFGLTNQGIVYAGWNPDWFKFFLGAMLLFAVFTNTAFARYTDSR
>NZ_CP038157.1|WP_136651202.1|1839882_1840881_+|sugar-ABC-transporter-substrate-binding-protein
MINTRKLFAALVTVSAAAALASCSSTGGAPESSAGGETAGGVDTPRYVVAMVSHGAPGDTFWDLVRKGAEDAAAKDNIELRYSSDPQAPNQANLVQSAIDAGVDGIAVTLPNAEAIGPAAQRAVEAGIPTVGLNAGMNEYAEYGLSGFFGQDETVAGTAAGERLKDEGAKNVLCVIHEQGNSSQEARCAGVKEGLGDSGKVELLYVNGQDLVSAQATMQAKLAQDPGIDTVFGLQAPVAMRAIDAVKDAGSDAEIATFDTNAELVDAIADGSVKWAVDQQPYLQGYLAVDSLWLAKRNGGTIGGGQPVYTGPSFVDASNVDKIAEAAKAGMR
>NZ_CP038157.1|WP_136651201.1|1839525_1839780_+|hypothetical-protein
MSQETVSRRPVAWLLIIAVWVATPYNSPHNPNLSWYLYVVLLAVTVVYGLATAVSRRDWLLYPALILTLFAWPIMTFAVFLYFA
>NZ_CP038157.1|WP_136651200.1|1838608_1839460_+|PPK2-family-polyphosphate--nucleotide-phosphotransferase
MARISVEEAQQFRVDENFQLADVDPTATPGLDSDKKVDKAFDTFDDELEDLQEMLFANARAGNSDAGSILLILQGMDTSGKGGLIKHVVGSTMDLQGVRVHAFGPPTEEERAHDFLWRFEPHVPEPGMVAVFDRSHYEDVLVQRVKQMAPPEEIERRYGAIVEWESELAARGVEIIKVMPHISREFQEENLRERILNEEKHWKYNPGDIDDRRLWSQYMAAYQIALTRTSTDAAPWYCIPSDNKDYCRTVVKTLMYDALKSLGLSWPEADFDPEVELERLAHS
>NZ_CP038157.1|WP_144318211.1|1838028_1838595_+|transcription-antitermination-factor-NusB
MTDYKRRGARYRARRRAVDILFEAETRDIDPVAVVEDRIELAQDPQNAVAPIAEYTREIITGVAEKLDDVDDAVERFLSQDWELGRLPAVDRQILRVAAWEILFNDDVAAPIAISNALGMAEEYAGHAAPPYIHAVLDDVVKTLPAPEADSPADESAEREDVLGEIIAEAPIAEPRALDIERDEPHKA
>NZ_CP038157.1|WP_006840229.1|1837465_1838029_+|elongation-factor-P
MATTADFKNGLVLKVDNKLQQIIEFQHVKPGKGPAFVRTKLKDVVSGKTVDKTWNAGVKVETATVDRRDMTYLYNDGTSYVVMDDKTYEQYELPEDKFGEASRFLLENMRVQVSFHEGEALFAELPISVDLKIEHTEPGLQGDRSTGGTKPATLETGAEIQVPLFLETGNVVKVDTRTGEYLSRVNQ
>NZ_CP038157.1|WP_144318210.1|1836304_1837396_+|M24-family-metallopeptidase
MPLADTRFATRRRKLASMLAAQRVDEMLVTNLINVRYLAGFSGSNAALKISKDLSAEIATDGRYTTQVAVEVPDIEATITRQCAEALLSGVPEGRRVGFEADYVSVAALERLTKACPEGVTLVPVTGVIEQIRLTKDDIELRRLTEAARLAAQALTGLVEAGELAAGRTERDIAADLEYRMRVLGAERPSFDTIVASGPNSAMPHYSAGERTLVDGDLVTIDFGMHRQGFNSDMTRTFVVGHATDFAREIYDIVLRAQLAGINAATPGTALVDVDKAAREIIEDAGYGDYFTHSTGHGIGLEVHEAPAAAPTGKGVLEENMLLTIEPGIYVPGKGGVRIEDTLIITSGAPQVITEWDKALTIV
>NZ_CP038157.1|WP_136651197.1|1835871_1836318_+|type-II-3-dehydroquinate-dehydratase
MKVLVLNGPNLNRLGKRQPDVYGSETLADVVKRLGEAAAERRVELECRQSNHEGELIDWVHEAADGGWAVIINPGGLTHTSVALRDALAEVADGAGFIEVHISNVHSREEFRHHSYLSPIAIGVIAGLGTTGYDLALDYFVRRNHAAC
>NZ_CP038157.1|WP_136651196.1|1834825_1835875_+|3-dehydroquinate-synthase
MAVVEVNGPSPYKVHIGHSNLSGVAERVGAIGARKVLIVHQVPLAAVAREICRAVESANVECVLAPVPDAEDGKTMEVLSGLWELLGEKKFSRQDVVIGVGGGAATDLAGFVAATWMRGIKVIQVPTSLLGMVDAAVGGKTGINTAAGKNLVGSFHEPDSVFIDLERLITLPEEELISGSAELIKTGFIADPRILELYMDDPQAHYAELVERSVAVKASVVSQDLKESGLREILNYGHTLGHAIELRENYTWRHGNAVAVGMMFVAHLARNRGLIGDDIVEMHRNILERICLPTTYEAGAFDELYEAMTRDKKNRDGRVRFVVLDSLGSCTRIEDSTIEEMRDAYSAIS
>NZ_CP038157.1|WP_144318213.1|1843319_1844654_-|TIGR01777-family-protein
MSLNASHHVLAPREKVWQWHTRPGAVVRLTPPFLPMRPIEQARSLADGTTTFALPARQRWVAKHVDTGYREGAQFQDTVVNQPLRTTTQWVHTHSFADAGDGATTVTDDIDTRVPRFLLEKAVAYRQHQLIADFKFLSTLPDTAPLTVAMTGASGLVGTALAAQLGTAGHTVIALSRSRGEGAGTRHWDVDKPAANLLSGVDAVIHLAGESIMGRFTEKKKRSILESRVGPTEKLARLAADSGVSTFVSASAVGYYGSDAGGYEHDESAPRGTGFLAEVCEQWEQASRVDGLRTVNIRTGLALSGAGGLLPVMRLSASTGAGARFGQGENWMSWIALDDLTDIYVRSLIDARLSGPVNATAPHPVTNAEFSATLTDILRRPDIVSIPKFGPAVLLGREGADELALASQRVVPRAATEAGADFRYPTLETALAHELGRESLVDQA
>NZ_CP038157.1|WP_136651206.1|1844857_1845424_+|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR
MSEKDSRAATELLNASDVARTIARIAHQIIEKNAIGADTSNVMLLGIPSGGVPLAERIAAAVEEFSGTSIPVGSLDVTLYRDDLRNRPHRALLPTNIPGEINGGIVILVDDVLFSGRTIRAALDAIADIGRPAAIQLAVLVDRGHRELPIRADYVGKNIPTARSEDVRVTLTPIDASDAVTLSREDTQ
>NZ_CP038157.1|WP_144318214.1|1845420_1846344_+|aspartate-carbamoyltransferase-catalytic-subunit
MKHLIDIKDLTRDEIVGIMDEADRFKEALHGRQMKKLPTLRGRTIFTLFYENSTRTRSSFETAGKWMSADVINLSASSSSVKKGESLKDTALTVEAVGADAIIIRHPASGAPHLLSQWLPGTCIINAGDGQHQHPTQALLDAVTMRQRIGDVQGRKVLVVGDVLHSRVARSNVDLLSTLGAEVVLVAPPTLLPTGVETWPARVSSHFDAELADADVVMMLRVQAERMNGGFFPSHREYATLFGLSAARAAALKDSAIIMHPGPMLRGMEINFGVADRDNAVVLDQVTNGVYTRMAVLFTLLAGEDNS
>NZ_CP038157.1|WP_144318215.1|1846340_1847624_+|dihydroorotase
MTTLALLNARPYGEDEVNILVKDGVIAQIGADVDPSGAGATYDCGGKVLLPGLVDMHVHLREPGREDTETIATGSDAAARGGFTAVFTMANTNPVIDQPFLADAVWEKGQAHGTCDVYPVGSITQGLRGEQLTEIGLMSRSHVRMFSDDGKCVNDPQLMRRAIEYAKAYDVLLAQHAEDHRMTEGACAHEGETAARLGLRGWPRVAEESIVARDAIMTRDYGGRLHICHASTEGTVELLRWAKAQGINVTAEVTPHHLLLTDEKLETYDGNFRVNPPLREDRDARALREALLDGTVDVVATDHAPHGSEDKCVEFEHAKPGMLGLETSLAVVAKVFVESGRADWRFVAKVMSERPAQILKLADQGRPIAVGEPANLALVNPTAAWTARGEEMASKASNTPYEGMDFAARVELTLLRGALTHSSIESN
>NZ_CP038157.1|WP_144318216.1|1847642_1848794_+|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MTNERIPAVLVLGDGHVFRGYSFGASGEVFGEAVFTTAMTGYQETMTDPSYHRQIVVMTAPQIGNTGWNDEDNESHDNQIWVAGLVIRDLAKRVSNWRAERSLEEEMASQSVVGICGVDTRTVVRHLRTEGSIAAGIFIGDAARASVDTLVARVNEQPSMAGADLADEVSTDKPYTVSAKGEKRYTVVAYDMGIKSATPGHFADRGIETIVVPANTPYSEITQYNPDGVFISNGPGDPATADAMVNVTRDVIAAGVPLFGICFGNQILGRALGLGTTKMKFGHRGVNVPVKNHLTGKIDITSQNHGFVLEAPVGPGESFDTDFGPALVTHTCLNDGSIEGVALESGMAYSVQYHPESAAGPHDANPLFDQFIELMDNASPNKK
>NZ_CP038157.1|WP_144318217.1|1848816_1852158_+|carbamoyl-phosphate-synthase-large-subunit
MKREDINHVLVIGSGPIVIGQACEFDYSGTQACRVLKDEGLRVTLINSNPATIMTDPEFADHTYVEPIEPDYIDKILAREAEQGHPVDAILATLGGQTALNAAIQLDRAGILAKHGVELIGANIDAIERGEDRQKFKDIVAKIGGESARSRVCHTMDEVHATVAELGLPVVVRPSFTMGGLGSGLAFSMEDLDRIAGGGLEASPEANVLIEESILGWKEFELELMRDGDDNVVVIASIENVDALGVHTGDSVTVAPALTLTDREYQTMRDQGIAIIREVGVDTGGCNIQFAVNPDDGRIITIEMNPRVSRSSALASKATGFPIAKIASKLAIGYTLDEITNDITGVTPAAFEPTLDYVIVKMPRFAFEKFPGSDETLGTSMKAVGEAMGIGRNYIQGLNKVMRSMEDKPNGFWTRPDSYFAPGRETDLSAVLDDLRTPTDKRMYDVELALRLGASIEQVHEASHIDPWFLAELAALVEFRQELIDAPVLDKELLREAKVYGLSDAQIAALRPELAGEQGVRSLRLSLGVHPVFKTVDTCAGEFEAQTPYHYSTYEYDEAAESEIAASGKDKVIILGSGPNRIGQGIEFDYSCVHAALELSRIGYETVMVNCNPETVSTDYDTADRLYFEPLTFEDVMEIYRAESASGNVAGVIVQLGGQTPLGLAQQLADAGVPVVGTSPEAIDLAEDRGEFGKVLDAAALPAPAYGTATSFAEAREVADRIGYPVLVRPSYVLGGRGMEIVYDEASLEDYINRATELSPDHPVLVDRFLDSAIEIDVDVLCDGTEVYLGGVMEHIEEAGIHSGDSSCALPPMTIGPEDIAKVRRSAEALAHGIGVRGLMNVQFALKDDILYVIEANPRASRTVPFVSKATGVHLAKAASRIMMGATIAELKDEGMLPTDYDGGALPLEHPIAVKEAVLPFTRFRTPAGEVLDTILGPEMKSTGEVMGLAPSFGVAYAKAEAAAFGELPTEGTVFVSVANRDKRSLIFPIQRLSTMGFTIVATAGTASMLRRNGIDCEVALKASEVRDGAEGTSIVERIASGEIDLILNTPAGSAGARHDGYEIRATAAANNVPLVTTVQGVVAAVQGIEAIRDNEVTVMSLQELDHNPAGGQ
>NZ_CP038157.1|WP_144318218.1|1852158_1852968_+|orotidine-5'-phosphate-decarboxylase
MGFGEQLVSAGERFGRLCVGIDPHAALLEQWGLNDDAAGLRDFAMTCVEAFADHVALVKPQVAFFERFGSAGYAVLEEVLAVLRASDSLVVADAKRSDIGSTMEGYARAWLAEGSPLEADAVTLTPYLGVGSLAPAFDLARASGKGVFVMAANSNPEAEQFQSQTVGGVSIAQQMVDACAELNRSNSQNGVGDIGVVVGATVARPPRLDELNAVVLMPGVGAQGATLDDVSRVAGDAAHLVFPNVSRSVLAAGPDARELRKRARELAKR
>NZ_CP038157.1|WP_136651212.1|1853200_1853524_+|integration-host-factor
MALPQLTDEQRKEALAKAAEARKQRAELKASLKRGDTNLKDVLDKADSDEIIGKTKVSALLEAMPKVGKVKAREIMEELEIAQTRRLRGLGERQRRALLERFGFSEA
>NZ_CP038157.1|WP_144318219.1|1853527_1854118_+|guanylate-kinase
MADVTPRGRLVVLAGPSAVGKSTVVHRLRTDVPNLYFSVSMTTRGPRPGEVDGEDYFFVTAEEFQRHIDAGAMLEWADIHGGLQRSGTPAGPVRDALSVGRPVLIEVDLVGARNIKALLPEAQTVFLAPPSWDVLVERLTGRGTESPEVIERRLATAREELEARGEFDCVVVNDNVGDAVSAIADILLSTPNNNNE
>NZ_CP038157.1|WP_170228699.1|1854146_1854455_+|DNA-directed-RNA-polymerase-subunit-omega
MTAETDSAAAGSAERDDSLVYDTPEGITAPPIDELLGKVSSKYALVIFAAKRARQINSYYQEQDEGVFEFIGPLVTPEQGEKPLSIALREIQAGLLEHEEGH

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Crispr_ID: NZ_CP038157_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_8

1930179-1930382

Orphan

Consensus_repeat	Method
AGTCCGCAATGCGGACT	PILER-CR

3 spacers

WYL

The CRISPR arrays of NZ_CP038157_8

>merge|NZ_CP038157|8|1930179-1930382|PILER-CR
AGTCCGCAATGCGGAGTGATTCGGGCTTAATTTGGGCTGGAAGGCGTTTGGTGACTCATCAACCGAGTCCGCAATGCGGAGTCGCTAGACCCCAGCCATGGCCTAGAACCGTTCGGTGACGCGTCATGCTAGTCCGCAATGCGGACTCGCAAGCCGCCCAAACGCGCCTGCCCCAACCTCTCGAACGAGTCCGCAATGCGGACT

>NZ_CP038157|8|4|1930179-1930382|PILER-CR
AGTCCGCAATGCGGAGT	GATTCGGGCTTAATTTGGGCTGGAAGGCGTTTGGTGACTCATCAACCG
AGTCCGCAATGCGGAGT	CGCTAGACCCCAGCCATGGCCTAGAACCGTTCGGTGACGCGTCATGCT
AGTCCGCAATGCGGACT	CGCAAGCCGCCCAAACGCGCCTGCCCCAACCTCTCGAACG
AGTCCGCAATGCGGACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_144318267.1\|1924213_1925641_+\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|237031
NZ_CP038157.1\|WP_144318277.1\|1936282_1937674_+\|Pup--protein-ligase	unknown	unknown	gnl\|CDD\|274725
NZ_CP038157.1\|WP_136648467.1\|1937673_1938618_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP038157.1\|WP_144318274.1\|1934015_1934591_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	unknown	unknown	gnl\|CDD\|237411
NZ_CP038157.1\|WP_144318276.1\|1936090_1936279_+\|ubiquitin-like-protein-Pup	unknown	unknown	gnl\|CDD\|368536
NZ_CP038157.1\|WP_144318266.1\|1923333_1924182_+\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234781
NZ_CP038157.1\|WP_144318262.1\|1920751_1921966_+\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	unknown	unknown	gnl\|CDD\|132488
NZ_CP038157.1\|WP_144318279.1\|1939603_1939861_+\|Sec-independent-protein-translocase-subunit-TatA	unknown	unknown	gnl\|CDD\|234797
NZ_CP038157.1\|WP_144318264.1\|1922398_1923043_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|223710
NZ_CP038157.1\|WP_144318273.1\|1933137_1934022_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	unknown	unknown	gnl\|CDD\|179769
NZ_CP038157.1\|WP_144318271.1\|1930506_1931742_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP038157.1\|WP_144318272.1\|1931719_1933102_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224089
NZ_CP038157.1\|WP_144318269.1\|1927818_1928652_+\|tRNA-(adenine-N1)-methyltransferase	unknown	unknown	gnl\|CDD\|225317
NZ_CP038157.1\|WP_144318268.1\|1926455_1927661_+\|M18-family-aminopeptidase	unknown	unknown	gnl\|CDD\|235073
NZ_CP038157.1\|WP_144318263.1\|1921989_1922370_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144318270.1\|1928661_1930176_+\|proteasome-ATPase	unknown	unknown	gnl\|CDD\|200312
NZ_CP038157.1\|WP_144318278.1\|1938607_1939552_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP038157.1\|WP_144318275.1\|1934587_1936081_+\|proteasome-accessory-factor-PafA2	unknown	unknown	gnl\|CDD\|274726
NZ_CP038157.1\|WP_144318265.1\|1923053_1923317_+\|phosphoribosyl-ATP-diphosphatase	unknown	unknown	gnl\|CDD\|212154
NZ_CP038157.1\|WP_136648444.1\|1925637_1926429_-\|RecB-family-exonuclease	unknown	unknown	gnl\|CDD\|225441

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_144318267.1\|1924213_1925641_+\|aspartate-ammonia-lyase	gnl\|CDD\|237031	PRK12273, aspA, aspartate ammonia-lyase; Provisional.	0
NZ_CP038157.1\|WP_144318277.1\|1936282_1937674_+\|Pup--protein-ligase	gnl\|CDD\|274725	TIGR03686, pupylate_PafA, Pup--protein ligase. Members of this family are the Pup--protein ligase PafA (proteasome accessory factor A), a protein shown to regulate steady-state levels of certain proteasome targets in Mycobacterium tuberculosis. Iyer, et al (2008) first suggested that PafA is the ligase for Pup, a ubiquitin analog attached to an epsilon-amino group of a Lys side-chain to direct the target to the proteasome. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP038157.1\|WP_136648467.1\|1937673_1938618_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.11987e-24
NZ_CP038157.1\|WP_144318274.1\|1934015_1934591_+\|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT	gnl\|CDD\|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	7.93661e-85
NZ_CP038157.1\|WP_144318276.1\|1936090_1936279_+\|ubiquitin-like-protein-Pup	gnl\|CDD\|368536	pfam05639, Pup, Pup-like protein. This family consists of several short bacterial proteins formely known as (DUF797). It was recently shown that Mycobacterium tuberculosis contains a small protein, Pup (Rv2111c), that is covalently conjugated to the e-NH2 groups of lysines on several target proteins (pupylation) such as the malonyl CoA acyl carrier protein (FabD). Pupylation of FabD was shown to result in its recruitment to the mycobacterial proteasome and subsequent degradation analogous to eukaryotic ubiquitin-conjugated proteins. Searches recovered Pup orthologs in all major actinobacteria lineages including the basal bifidobacteria and also sporadically in certain other bacterial lineages. The Pup proteins were all between 50-90 residues in length and a multiple alignment shows that they all contain a conserved motif with a G [EQ] signature at the C-terminus. Thus, all of them are suitable for conjugation via the terminal glutamate or the deamidated glutamine (as shown in the case of the Mycobacterium Pup). The conserved globular core of Pup is predicted to form a bihelical unit with the extreme C-terminal 6-7 residues forming a tail in the extended conformation. Thus, Pup is structurally unrelated to the ubiquitin fold and has convergently evolved the function of protein modifier.	1.24638e-09
NZ_CP038157.1\|WP_144318262.1\|1920751_1921966_+\|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase	gnl\|CDD\|132488	TIGR03447, mycothiol_MshC, cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase. Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	0
NZ_CP038157.1\|WP_144318279.1\|1939603_1939861_+\|Sec-independent-protein-translocase-subunit-TatA	gnl\|CDD\|234797	PRK00575, tatA, Sec-independent protein translocase subunit TatA.	3.73465e-21
NZ_CP038157.1\|WP_144318270.1\|1928661_1930176_+\|proteasome-ATPase	gnl\|CDD\|200312	TIGR03689, pup_AAA, proteasome ATPase. In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP038157.1\|WP_144318264.1\|1922398_1923043_+\|HAD-IA-family-hydrolase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	7.16262e-44
NZ_CP038157.1\|WP_144318273.1\|1933137_1934022_+\|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS	gnl\|CDD\|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	0
NZ_CP038157.1\|WP_144318271.1\|1930506_1931742_+\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	3.77624e-12
NZ_CP038157.1\|WP_144318269.1\|1927818_1928652_+\|tRNA-(adenine-N1)-methyltransferase	gnl\|CDD\|225317	COG2519, GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis].	5.99008e-104
NZ_CP038157.1\|WP_144318268.1\|1926455_1927661_+\|M18-family-aminopeptidase	gnl\|CDD\|235073	PRK02813, PRK02813, putative aminopeptidase 2; Provisional.	0
NZ_CP038157.1\|WP_144318266.1\|1923333_1924182_+\|ATP-phosphoribosyltransferase	gnl\|CDD\|234781	PRK00489, hisG, ATP phosphoribosyltransferase; Reviewed.	6.13399e-131
NZ_CP038157.1\|WP_144318272.1\|1931719_1933102_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	3.00161e-80
NZ_CP038157.1\|WP_144318278.1\|1938607_1939552_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.47751e-36
NZ_CP038157.1\|WP_144318275.1\|1934587_1936081_+\|proteasome-accessory-factor-PafA2	gnl\|CDD\|274726	TIGR03688, pupylate_PafA2, proteasome accessory factor PafA2. This protein family is paralogous to (and distinct from) the PafA (proteasome accessory factor) first described in Mycobacterium tuberculosis (see TIGR03686). Members of both this family and TIGR03686 itself tend to cluster with each other, with the ubiquitin analog Pup (TIGR03687) associated with targeting to the proteasome, and with proteasome subunits themselves. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP038157.1\|WP_144318265.1\|1923053_1923317_+\|phosphoribosyl-ATP-diphosphatase	gnl\|CDD\|212154	cd11547, NTP-PPase_HisE, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. This family includes M. tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs. M. tuberculosis HisE is encoded by the hisE gene, which is a separate gene presenting in many bacteria and archaea but is fused to hisI in other bacteria, fungi and plants. HisE is responsible for the second step in the histidine-biosynthetic pathway. It can irreversibly hydrolyze phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate. HisE dimerizes into a four alpha-helix bundle, forming two inferred PRATP active sites on the outer faces. M. tuberculosis HisE has been found to be essential for growth in vitro, thus making it a potential drug target for tuberculosis.	8.45039e-40
NZ_CP038157.1\|WP_136648444.1\|1925637_1926429_-\|RecB-family-exonuclease	gnl\|CDD\|225441	COG2887, COG2887, RecB family exonuclease [DNA replication, recombination, and repair].	2.12362e-52

>NZ_CP038157.1|WP_144318270.1|1928661_1930176_+|proteasome-ATPase
MIEDDAFGPQLRELKRENQAMGARNKQLAELLKASRDKLNDLYAQLESLEEPANPYGVYLSGSRKGMEAEIFTSGRRMRVKVSPNVAPGSLVPGTLVRLGDGTVIVEACGFDSAGQLGTMVERIGTDRAVVADQQGGESLVHLAQPLLDTARSGDTLLFDPRVGFAYERVPKTEVNQLSLEEVPDVTYADIGGLSTQIETIRDSVELPFVHPELYKAYDLAPPKGLLLYGPPGCGKTLIAKAVANSLSSSIGEGGSAHFINVKGPELLNKYVGETERRIRLIFERARELASEGRPVIVFFDEMESIFRTRGSGVSSDMETTVVPQLLTEIDGVEGLANVIVIGATNREELIDPAILRPGRLDIKIRVSRPTKDEAKDIFARHLTESVPHAEPVPSLIDAAVDALFAPRPFVRLELVDGSTEMLHYHDFVSGAMIANVVARAKKLAIKDHASGASSSGLSAEHLRIAVRAEQDENEDLPNTANPDEWARITGRQGRRVVGAEVVG
>NZ_CP038157.1|WP_144318269.1|1927818_1928652_+|tRNA-(adenine-N1)-methyltransferase
MYSGPFQAGDKVQLTDAKRRHFTIELVEGGQFHTHKGIVAHDDIIGIDEGSVVRSSLGSDYLCFRHLLVDHVLSMPRGAAVIYPKDAAQILVEGDIFMGARVLEAGAGSGALSMSLLRAVGPEGKVFSYEIREDHFAFARDNVAEYFGSEPAWWEPRLGDFGEVTREDVGGPVDRIILDMVEPWLFINTVKDLLIPGGVFMTYVATVPQLMNIMEAIREAKCFTEPRAWETLLREWKVEGLATRPEHRMNAHTAFLVWTRRLADGVTPPRPQRKARR
>NZ_CP038157.1|WP_144318268.1|1926455_1927661_+|M18-family-aminopeptidase
MTLTDTADFLKFLDASPSAFHAAVNVESMLIDAGYAPDSDLTPGGHVVVSGGAVLAWWVPRKSNPRVRIVGSHTDSPGLMVKPDPDFVREGFTQVAVEVYGGPILSSWFDRDLRFAGRVVCADGSVKLVDTGAVARVPNLAIHLTRGADQGIDRQVHLQPIVGGNLPLSELVARAAGVDAGEIVAHELISADTQPAAVVGDSVMSGRLDNLSSVFASVQALLRAQDSAEDVLVLAAFNHEEVGSASTTGAGGPLLERLLARITASLGDPLDFYTGSLAVSADAAHSVHPNYPGKHDPTHRPLLGKGPVLKINANQRYASDAVSSAAWIRAARAANVPVQTFVGHNDVPCGSTIGPISATRLGIPTVDVGVPLLSMHSAREQVGVQDMAWFTEALAAFLRGD
>NZ_CP038157.1|WP_136648444.1|1925637_1926429_-|RecB-family-exonuclease
MTSRPLALSPSRASDYKQCPLLYRFRAIDRLPEPKTEAQVKGTLVHAVLEEMHSWPREQRTYPAAVKAIVPAWERLIEQDPEVVEPISDRQQLLIDARTLIRGYFHMENPLGFDSTEQEMYVDGVLPNGVPVRGFIDRVDVAPTGEVRVVDYKTGKKPLPRYSADAQFQMRFYALVYWRFFGTIPAQLRLMYLKVIDSMILTPSREELEYFERDLGDLWAKIEADGREGRFRPRTSKLCDWCSFQDICPAFDGTPPEYPGWPS
>NZ_CP038157.1|WP_144318267.1|1924213_1925641_+|aspartate-ammonia-lyase
MATRIEEDLLGTMDVPANVYYGVHTLRAVDNFQISGTKINDIPDFIRGMAQVKKAAAMANRRLHVLPKSKAEAIIWACDEIIERGRCLDQFPIDIYQGGAGTSVNMNVNEVVANLALEYLGEEKGAYDVINPNDDVNMSQSTNDAYPTGFRLGLYYSVQGLLHQLDELQKAFRAKGDEFNDIIKMGRTQLQDAVPMTLGQEFTAFGSNLGEEQRTISTAANALLEINLGATAIGTGINTPSGYRDQVVAALREVTGLDIQASPDLIEATSDTGGYVMMHSAIKRAAMKLSKICNDLRLLSSGPRAGLNEINLPERQAGSSIMPAKVNPVIPEVVNQVCFKVFGNDITVSMAAEAGQLQLNVMEPVIAQSLFGSVKLLSNASATLREKCVTGITANREVCEAYVTNSIGIITYLNPLIGHHNGDLVGKEAARTGRGVRELILEKGLLTEEELNRALSKENLMHPEFRGKLYLDDES
>NZ_CP038157.1|WP_144318266.1|1923333_1924182_+|ATP-phosphoribosyltransferase
MIKVAVPNKGSLSEKALEVLKEAGYKGRGINKSLNVVDEENGVEFYFLRPKDIAIYVAQGHLDLGITGRDLAADSGADVNEVMSLGFGSSTFRFAAPADQQWSVADLEGKRIATSYPHLVKTYLAQHGITPSDVTRLDGAVEIAIKLGVADVIADVVSTGATLRQQGLAPFGEPLVSSEAVIIRRRGNEGGPDHDVLLKRIRGILNAQNFLMVDYNISRDNLKRASAITPGITGPTVSPLSREGWVAVRAMVPRKKANQTMDELAAVGAEGILATELRIARL
>NZ_CP038157.1|WP_144318265.1|1923053_1923317_+|phosphoribosyl-ATP-diphosphatase
MKNFDELFAELSAKAASRPADSGTVKALDKGEHFIGKKIIEEAGEVWIAAEYQSDAELAVEMSQLIYWTQVMMLKRGLTPDDVYKYL
>NZ_CP038157.1|WP_144318264.1|1922398_1923043_+|HAD-IA-family-hydrolase
MDGTLVDTEPLWGVATYELSEKLGRRLTPELREKTIGGSFGNTLAICAAHAGVELGPGDYERYKTWMYSRMGELTAGDLTPNPGVQSLLAALREAGVPMLVTTNTERVLADALINAVGRDFFVDSIAGDEVERTKPAPDMYLEAARRVGFDARDCLVFEDSWAGMSAAAAAGCRVLGLAETVPEGVVSFDPANFVGAALEDVARWYAEIVQPVR
>NZ_CP038157.1|WP_144318263.1|1921989_1922370_+|hypothetical-protein
MTIREQFQDDVDEFISDLTTFATGSYLRDEDKELWDEPFDPKVLPELKQKIEGFLDALELLGDDPAGEDLKKVIVPFYASLSEFNAAHANAVLEPEEKADLESLVFQAAAATGADDEALNELPELE
>NZ_CP038157.1|WP_144318262.1|1920751_1921966_+|cysteine--1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside-ligase
MHSWPTPEVPAVSGTPVELNLYDTADQVVKPVDTTPNANGEVGMYVCGITPYDSTHLGHAATYLTFDLVQRQLIANGHRVHYVQNITDVDDPLFERAERDGVDWRELGQSQIDLFRSDMSILGVIPPRDYIGAIESVDEVIEMVGKLLDASAAYRLDHGDIYASIDATAQFGYESNYSRAEMETYFAERGGDPEREGKRDPLDALVWRGHRDGEPAWDSPFGPGRPGWHIECSAIATNRLGATFSIQGGGSDLAFPHHEFSAAHAEAAYSEPRMATHYVHAGMIALDGVKMSKSLGNLVFVHKLTEQGHEPGAIRLAVFAEHYRTDRDFSDEILVTAEQRLARWRENLAHQVSSADADVVVDKLRAALADDLDTATALCVIDEAPGDCDGTVARAIDGLLGVQV
>NZ_CP038157.1|WP_144318271.1|1930506_1931742_+|HNH-endonuclease
MSTTITDLDHHQSPGAIVETIQQGFGSFTRKKAAVLMAVALFDALKLATRYGSPSTALWMVRTLSLSNSTAHEYVKVARAMLEFNLMSSAFLEGRIFYSKVRLILPHMTAENEAELVELAASMTYHELELALLRYRKSGEGLARKSYVRLKARSDGRIGMWADFNAAEGARVMAAMKVGELAFHDVDWDALRDPSGQIDKGKLGAEIDERTAGCSGFGLPLGEALVSAFMGVVNIALTRPKNSLRAPGAHVNVVMTTDGGAYLPNNPGASSDAVKNFLSNASYRVNRVDEHGLVLNTGRAFRLANDAQVNALMLMWRGQCAMPGCSHTRFMEMHHIHDWADGGASDLDNLLPLCSACHSLVTDGAVTIRKELGDIHFVFPDGTRYVSHNRALPVRDDDALTLEEFNSAAWC
>NZ_CP038157.1|WP_144318272.1|1931719_1933102_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MPLIADYFGPVVFRVDRHHPTSIPAQIASGMRGLVASGQLAAGDRVPSTRELAGQLGVSRGSVVTAYDQLISEGLLKSSQGAATVVHPELRRVSTPPPTRPVPGRSRADRPISLKPSAGTAGAIRPAAWRRAWREAASFAPAALDRSGQPELRRAIAEHLRLARGLVVDPDSVLVTGGSREGLLLILMSLGRALNVGVETPGHPGLRNVIPLAGHTAVSCATDERGLVVSALPEGLDALLVTPSHLYPIGGSMPATRRAALLEWAAERGVVIIEDDFNSELRYRVSPLPTLGTLPSKGSVIALGTFSTLLSRQLSAGYVVADAATSDRLRETRDTLGMPVSPVTQYAIAHLLEGGFVRRNTKATHKRLAERKETLARCVLPALRAFEAETIQQERSLGVDMVVRFPDPAAQGRFVGWLEECGVVGASISDGLLLSFGHLSEDDFERVVGVIASASTTRPS
>NZ_CP038157.1|WP_144318273.1|1933137_1934022_+|pyridoxal-5'-phosphate-synthase-lyase-subunit-PdxS
MSENTVKSGLAQMLKGGVIMDVVTPEQARVAEDAGAVAVMALERVPADIRAQGGVARMSDPDLIEGIIEAVDIPVMAKARIGHVIEARILEHLGVDYIDESEVLSPADYVNHIDKRPFTVPFVCGATNLGEALRRINEGAAMIRSKGEAGTGDVSEATKHIRTIKAEIAGLQSLWNSNRDELYVAAKELQAPYELVAHVAEHGELPVVLFTAGGVATPADAALMMQLGADGVFVGSGIFKSGDPAARAAAIVKATAAWEDIAVVTEASRGLGEAMVGINVGDLPAPHRLAERGW
>NZ_CP038157.1|WP_144318274.1|1934015_1934591_+|pyridoxal-5'-phosphate-synthase-glutaminase-subunit-PdxT
MVRIGVLALQGGVREHVEMLEDLGAEVTLLRRAAELARLDGVVIPGGESSTIDRLMRIFSLDDALRTALHHGTPVLGTCAGLITLATEIVDPAPGQRSLGIIPMRVRRNAFGRQVDSAVETIDSAYNQVTAAYIRAPEVVAVGEGVKVIATKGERIVGVETDSALAVSFHPELTGDTTIHARFLDKVASSA
>NZ_CP038157.1|WP_144318275.1|1934587_1936081_+|proteasome-accessory-factor-PafA2
MTRYMGTETEYGITSPSDSSLSPIVTSTHAVVAYAAMHTGARARWDYEDEAPLKDARGFDLRRYHTVPIVDANAIGVANVVTSNGARFYVDHAHPEYSSPEVSNAFDAMIYDAAGDVVLGEAAASIAELHAQGVSVLKDKDPCPPLKFYKNNVDGKGASYGSHENYQYSRHTDFGVLAKALIPFFVTRQVIIGAGRVGIGQEGERDGFQISQRADYFEQEISLETTLNRGIVNTRDEPHANEEHFRRLHVIVGDANMSQYSNFVKLGMTKLVLDAIEGGVNFSDLALANPVAEIKNVSHDPSCTHELSLIDGRTLSAIDILRVYRERVAAESDVDKQVLELWGELLDDLARDPLSTADRLDWTAKWALVSAYLKRGVDIADPKLKALDLQYADIDPATSLHHALVRKGRMRTLVDTETIRRAAVTPPDDSRAYFRGTVSSTFGDSILASNWQAVLFNTDQGPYKVRIDDVDGFTRADVGELIESAGSVDELIAALNR
>NZ_CP038157.1|WP_144318276.1|1936090_1936279_+|ubiquitin-like-protein-Pup
MAQQQIHGGSGDGNGSEDDGAFETDQAQLNTSGTDDLLDEIDALLDNNAEEFVRFYVQKGGE
>NZ_CP038157.1|WP_144318277.1|1936282_1937674_+|Pup--protein-ligase
MFTRRVMGVETEFGVTAFRDGSQVLSPEEVARYLFRPVVSAHRSSNIFVDNASRLYLDVGAHPEYATAECDSITQLLNSDKAGELIFDRLSRTAEEALAADRIGGEIYLFKNNVDSRGNSYGAHENYLISRELALKPFSLQLMPHMITRQLICGAGLIKKNRFVISQRADQVWEGVSSATTRTRPIINTRDEPHGDSHRFRRMHVIVGDSNMAEPTFALKIGSTLLVIEMLEAGFAMPNFELDNPIEHIRDISADPTGATVLRLKDGSAATALEVQRGIFEAARAWLAQRPDEGTPNAEMARVVDLWGRTLDAIETKDFSGVDQEIDWVIKRKLLEQFKTRLGCDWDHPKLAHVDLAYHDIRRERGLFYHLQRKGLVKRWTTDEAIEQATTTAPRTTRAALRGRFLAAARESGASVNVDWVHLKVNHPEPRTVALFDPFATDGEASADVEKLVEYMLENHQEG
>NZ_CP038157.1|WP_136648467.1|1937673_1938618_+|WYL-domain-containing-protein
MANDDPAIDRLTNLTFALLGTQRPRDYEWVRGRVEGYKDYADSEKGRASFHRQLNRDIQTIRRAGVPARMENGLVWVDKDAYTLPPIEFTDEEATVLGLAGDLGRERSLGAFARSGWTKLAASGATRSFDSPALASVDNDVMRLDAETVKGVTACVRAKKRMVFDYAPAPAADVQRRVMDPWGIVALNNRAYVVGWDAEREAERAFRAMRVSNVRVTSAERFHAASRPLADVVNDILRGPVTDARIGVATSASFELETKGTRVGDVVEFVGVERDWLVRTVASVAPDVFEIEPDDVRRDVIALLSATVEASDEG
>NZ_CP038157.1|WP_144318278.1|1938607_1939552_+|WYL-domain-containing-protein
MKDSPAKLEGLVRSLNLIPYLHSHREATPMEIARDLGYSHEEVMRDLTRLSMSGVGSGPGELIDLVANWTGITVIDDQGLNKPLRLTPTEANALLLTLESLETMPGLVDQAAVTSAAAKLRAAIKGHSVDDTEPEVEASTSDVHILTDAIARSRQLEIVYYSASSGTTSTRIVSPASIFHQNGQTYLRAYEEGLAEAKSFRLDRISNAQLLDAPSNAPSNPTGFDPNDPFGFSTRRRAELAIRRDATWLADYFEIELDSDLGSGDWVRATMAYGNDDWLIRFCLSQGDRVRLVEPGNLARETVRRAQTGVDGLS
>NZ_CP038157.1|WP_144318279.1|1939603_1939861_+|Sec-independent-protein-translocase-subunit-TatA
MPSLGWPEILIILAIVLLLFGANKLPDLARSMGRSARIFKSEVNEMRNDDKPAPVQAELPQAAPETQSAAQSATQIADNQPRPQN

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Crispr_ID: NZ_CP038157_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP038157_9

2111207-2111676

Orphan

Consensus_repeat	Method
ANTCCGCATTGCGGACTC	CRT

7 spacers

The CRISPR arrays of NZ_CP038157_9

>merge|NZ_CP038157|9|2111207-2111676|CRT
AGTCCGCATTGCGAACCCGTGGACTCCACGCACTCTGCAGCGGCAGAGTGGCCAGTCCGCATTGCGGACTCTGCCGGCAGCCTTGCTTGCCGACGCTCAACTTCACGGTCGCCCCGACTCCGCATTGCGGACTCTACATTGCGGACTCTGCAGCGGCAGAGTGGCCAGTCCGCATTGCGGACTCCGCAGCAGCAAAGGCAAACTGTGAAAACACTGCACAGAAAGCCACCTGGGTGTTGACGGATTCCGCGCACTCTGCATTGCGGACTCCACCCGGCCCCCGCTAACCAACACTCAATCAAACCCCACCCCAACTCCGCATTGCGGACTCCACACGCAGCCTTGCTTGCCGACGCTCAACTTCACGGTCGTCCCGACTCCGCATTGCGGACTCTACAAACTCCGCAGCGCCAGAGTGACTACTCTACAAACTCCGCAGCGGCAGAGTGACCACTCCGCATTGCGGACTC

>NZ_CP038157|9|2|2111207-2111676|CRT
AGTCCGCATTGCGAACCC	GTGGACTCCACGCACTCTGCAGCGGCAGAGTGGCC
AGTCCGCATTGCGGACTC	TGCCGGCAGCCTTGCTTGCCGACGCTCAACTTCACGGTCGCCCCG
ACTCCGCATTGCGGACTC	TACATTGCGGACTCTGCAGCGGCAGAGTGGCC
AGTCCGCATTGCGGACTC	CGCAGCAGCAAAGGCAAACTGTGAAAACACTGCACAGAAAGCCACCTGGGTGTTGACGGATTCCGCGC
ACTCTGCATTGCGGACTC	CACCCGGCCCCCGCTAACCAACACTCAATCAAACCCCACCCCA
ACTCCGCATTGCGGACTC	CACACGCAGCCTTGCTTGCCGACGCTCAACTTCACGGTCGTCCCG
ACTCCGCATTGCGGACTC	TACAAACTCCGCAGCGCCAGAGTGACTACTCTACAAACTCCGCAGCGGCAGAGTGACC
ACTCCGCATTGCGGACTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP038157.1\|WP_144318373.1\|2105193_2106777_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|237436
NZ_CP038157.1\|WP_144318381.1\|2119315_2120647_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|172015
NZ_CP038157.1\|WP_144318380.1\|2117466_2119305_+\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|237104
NZ_CP038157.1\|WP_144318384.1\|2122587_2124009_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226458
NZ_CP038157.1\|WP_144318374.1\|2106863_2107718_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_136653521.1\|2112854_2113370_-\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
NZ_CP038157.1\|WP_144318378.1\|2113371_2115225_-\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236098
NZ_CP038157.1\|WP_136653505.1\|2102632_2102818_-\|YbdD/YjiX-family-protein	unknown	unknown	gnl\|CDD\|377308
NZ_CP038157.1\|WP_144318371.1\|2101559_2102576_-\|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl\|CDD\|179579
NZ_CP038157.1\|WP_136653528.1\|2116941_2117460_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP038157.1\|WP_136653499.1\|2098176_2100039_-\|cyclic-nucleotide-binding/CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|225457
NZ_CP038157.1\|WP_144318383.1\|2121439_2122498_+\|glutathione-S-transferase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|223512
NZ_CP038157.1\|WP_144318382.1\|2120530_2121334_-\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP038157.1\|WP_144318376.1\|2109505_2110411_-\|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl\|CDD\|224151
NZ_CP038157.1\|WP_144318372.1\|2102818_2105104_-\|carbon-starvation-protein-A	unknown	unknown	gnl\|CDD\|184976
NZ_CP038157.1\|WP_144318375.1\|2107732_2109475_-\|DUF262-domain-containing-protein	unknown	unknown	gnl\|CDD\|226003
NZ_CP038157.1\|WP_136653516.1\|2110667_2111096_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378918
NZ_CP038157.1\|WP_144318370.1\|2100048_2101518_-\|cell-wall-binding-repeat-containing-protein	unknown	unknown	unknown
NZ_CP038157.1\|WP_144318379.1\|2115489_2116932_+\|mechanosensitive-ion-channel	unknown	unknown	gnl\|CDD\|223740
NZ_CP038157.1\|WP_144318377.1\|2111751_2112768_-\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491

Protein	Function_ID	Function_description	E-value
NZ_CP038157.1\|WP_144318373.1\|2105193_2106777_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|237436	PRK13581, PRK13581, D-3-phosphoglycerate dehydrogenase; Provisional.	0
NZ_CP038157.1\|WP_144318381.1\|2119315_2120647_+\|DUF2029-domain-containing-protein	gnl\|CDD\|172015	PRK13375, pimE, mannosyltransferase; Provisional.	6.50762e-27
NZ_CP038157.1\|WP_144318380.1\|2117466_2119305_+\|dihydroxy-acid-dehydratase	gnl\|CDD\|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0
NZ_CP038157.1\|WP_144318383.1\|2121439_2122498_+\|glutathione-S-transferase-C-terminal-domain-containing-protein	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	4.93024e-139
NZ_CP038157.1\|WP_136653505.1\|2102632_2102818_-\|YbdD/YjiX-family-protein	gnl\|CDD\|377308	pfam04328, Sel_put, Selenoprotein, putative. This entry includes a group of putative selenoproteins from Proteobacteria, Actinobacteria and Firmicutes. The invariant cysteine at the C-terminus is encoded by a TGA Sec codon in some Epsilonproteobacteria, suggesting a redox activity for the protein.	5.35123e-22
NZ_CP038157.1\|WP_144318378.1\|2113371_2115225_-\|acetolactate-synthase-large-subunit	gnl\|CDD\|236098	PRK07789, PRK07789, acetolactate synthase 1 catalytic subunit; Validated.	0
NZ_CP038157.1\|WP_136653521.1\|2112854_2113370_-\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	3.1146e-78
NZ_CP038157.1\|WP_144318371.1\|2101559_2102576_-\|3-isopropylmalate-dehydrogenase	gnl\|CDD\|179579	PRK03437, PRK03437, 3-isopropylmalate dehydrogenase; Provisional.	0
NZ_CP038157.1\|WP_136653528.1\|2116941_2117460_+\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	1.60608e-08
NZ_CP038157.1\|WP_136653499.1\|2098176_2100039_-\|cyclic-nucleotide-binding/CBS-domain-containing-protein	gnl\|CDD\|225457	COG2905, COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms].	0
NZ_CP038157.1\|WP_144318384.1\|2122587_2124009_+\|hypothetical-protein	gnl\|CDD\|226458	COG3949, COG3949, Uncharacterized membrane protein [Function unknown].	2.1048e-86
NZ_CP038157.1\|WP_144318382.1\|2120530_2121334_-\|DoxX-family-membrane-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	5.68707e-09
NZ_CP038157.1\|WP_144318376.1\|2109505_2110411_-\|cation-diffusion-facilitator-family-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	5.74203e-88
NZ_CP038157.1\|WP_144318372.1\|2102818_2105104_-\|carbon-starvation-protein-A	gnl\|CDD\|184976	PRK15015, PRK15015, carbon starvation protein CstA.	0
NZ_CP038157.1\|WP_144318375.1\|2107732_2109475_-\|DUF262-domain-containing-protein	gnl\|CDD\|226003	COG3472, COG3472, Uncharacterized conserved protein [Function unknown].	1.04554e-67
NZ_CP038157.1\|WP_136653516.1\|2110667_2111096_+\|hypothetical-protein	gnl\|CDD\|378918	pfam12685, SpoIIIAH, SpoIIIAH-like protein. Stage III sporulation protein AH (SpoIIIAH) is a protein that is involved in forespore engulfment. It forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling. This family of proteins is found in bacteria, archaea and eukaryotes and so must have a wider function that in sporulation. Proteins in this family are typically between 174 and 223 amino acids in length.	0.00261299
NZ_CP038157.1\|WP_144318379.1\|2115489_2116932_+\|mechanosensitive-ion-channel	gnl\|CDD\|223740	COG0668, MscS, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	9.60361e-29
NZ_CP038157.1\|WP_144318377.1\|2111751_2112768_-\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0

>NZ_CP038157.1|WP_136653516.1|2110667_2111096_+|hypothetical-protein
MTNQNPTPDPKDPRNLDKDAVANADVTRVEKTTTPATTSATAGSTAVTANEGGGWWKWLLGLLALLLIGWLLWSLFANNDDEAATTGETSTSVVSTETENVTETAVVSGESEPANPAESAGNAAEGAAENAGDAVESAAPTN
>NZ_CP038157.1|WP_144318376.1|2109505_2110411_-|cation-diffusion-facilitator-family-transporter
MSHTHEHSPAHAPRRALLTALAITTTVFFVEFVGGYLSGSMALMADSMHMLSDSAGLMIAVIGTLISQRASTAVATYGFARAEVLTALVNAVSVIAVTVWIVVEALSRLRDPAPIHTRTMMLVALIGLVANAASAVVLHRHKEGSINVRGAFLHVIVDLLGSVAVLAAGAVIALTGFTPADAIASLLIAVLVVPRAWQLLLQSLRVLLEQAPRGFATQRIEPTLRSIDGVIDVHDVHVWSLGGSDVVVTAHLVAHEDAPRGPLLDAAQQRLTDLGVDHPTIQVELPGHTDHERACGASLGR
>NZ_CP038157.1|WP_144318375.1|2107732_2109475_-|DUF262-domain-containing-protein
MGFTTPSYSLSDLFARVHRGELQLPDFQREYIWDVDRVRTLVTSVLRGYPIGSLLALDTRNVAPRFKSRPLDGAPQAQVQPGLLLLDGQQRLTSLFHAFSGDGVVPTVDFLGNRISRRFFVDIRRAVSAQPLPVEAVFAVDTNGDVRSHFGPAISGGLNTREGMLEHGVIPVSALLNDDANTLLIDLAAATEDPQMREAAAAFQSRVVSQLPAYDIPLVRIDRDTSLVGIGQIFAHANSAGVQMDVFELLTATFALQDPEFVVVEHWAGVEKQLREHPALDNIGRIEFLRAMSLLITGRHGPARGHRGDILSIDLEGYLAHADEVAAGFAAAAEFLAERRMLTTDQVPYTTQLVTLAVLLARLVDRPGVLDNEQSRDRLNRWFWSGVFGELYGAHSPIIRAGADVDEVTPWVMGETDTTPRTVEDARCTRARIVSAGPDSGVYRGLFALLMARDARDWRTGQAFECDTMERLEPTFELVFPRGVCDTRGVDPQFAESVVNRTPMGVRTRIFIEGNEPKRYLPRLQSKCLMEDAEFDAMLAAHEINPRTLFASDVDTFMRERLDRLATIIEHAMGKPVDES
>NZ_CP038157.1|WP_144318374.1|2106863_2107718_-|hypothetical-protein
MNRPTIVAPFIAAALALSACSSGPAASPLDDARTQNQARHVAERFAPHPVVLDDPYGFETSRLFFPASETVVVTDSTPQAQLRGASIAVTAHAPLLVYAPERHGEVLEEIQRLGTHTVLTIGDVAFAPASGRVTVQRDPGGLDALHTMTSLEFDVRDIEDTADARETVAAVASLAGNPPVWLRTREAPATKPGAQAAPFPLQSRRDADMAPVVVATPASPLPAVSNARSFGARVAVVDEPDPRQSRETLLALAGLANEPLIALGPEFGTEQELSRRIMQAEEYY
>NZ_CP038157.1|WP_144318373.1|2105193_2106777_-|phosphoglycerate-dehydrogenase
MSKPVVLIADKLAPSTVDALGDGVEVRWVDGPNRAELLAAVPEADALLVRSATTVDREVIEAAPQLKIIGRAGVGLDNVDIDAATERGVMVANAPTSNIHSACEHAIALLLATARQIPAADKTLRDAEWKRSAFKGVEVFGKTVGIVGFGHIGQLFAQRLAAFDTTIIAYDPYANPARAAQLGVELVELEELMSTADFVTIHLPKTKETAGMFNADLLAKSKQGQIIINAARGGLVDEQALADAIVSGRIRGAGFDVYASEPCTDSPLFGLDQVVVTPHLGASTEEAQDRAGTDVADSVLKALRGEFVADAVNITGGRVGEEVASWLDLSRKLGLLAGKLLDAAPVSLHVTSRGELSTEDVDTLGLSAVRGLFSGIVSEPVTFVNAPTIAESRGLEYTVDTASEARSHRSALEVQVASASGEVATVTGALTGLERVEKIVNINGRGVDMRAEGRNLFLRYTDAPGALGKVGSTLGEAGINIEAAALTQAAKGDGAVLILRVEREVPEELEAAIASSIDASSIQIDLS
>NZ_CP038157.1|WP_144318372.1|2102818_2105104_-|carbon-starvation-protein-A
MSVKVNGLRERPDADRLEISTTPDGREHVVGVRPKKAIGTVERVVIAIAAVIAALGWAVLALNRDEEISSVWLVLAAIGSYIIGYTLYARLIEYNVVKPRNTRATPAEYIDDGKDFVSTDRRVLFGHHFAAIAGAGPLVGPVMAAQMGYLPGTLWIIIGVVFAGAVQDYLVLWVSTRRRGRSLGQMISDEVGRVGGAAGIFATMVIMVIIIAVLALIVVNALADSPWGVFSIAMTIPIALFMGCYTRFIRPGRVAEVSAIGVILLLAAIIGGGYVADTAWGAEVFTLSKTALAFALIIYGVVAAILPVWLLLAPRDYLSTFMKVGVVALLAVAIIIDRPMIQMPAITSFAIEGNGPVFAGSLFPFLFITIACGALSGFHALISSGTTPKLIEKESHMRTIGYGSMLVESFVAVMAMITAVILNRHLYFAVNSPAAVTQGTPEGAAEFVATLNLPGDPITAQQLAETANAIGEATVVSRTGGAPTFALGMSEIMTNLLGNEALQAFWYHFAIMFEALFILTTVDAGTRVARFMMSDTLGSVPGLGKFKDQSWTIGSWISTFVVCGLWGAILVMGVTDPLGGINVLFPLFGIANQLLAAIALTLVTVVLVKKGLYKWVWIPVVPLVFDLVVTLTASWQKIFHSNPAIGYFAQNARFRDAKAQGLTEFGNAKSPEAIDAVIRNTYIQGALSILFASLVVIVVITALVAVVKALRAQSAGLRVPTSEEPDHPSTRFIPRGMAASAEEKRVAEELGLTLASSGGAH
>NZ_CP038157.1|WP_136653505.1|2102632_2102818_-|YbdD/YjiX-family-protein
MVLKVINGVTWYIKELMGDNDYAKYCAHLAAHHPGAEPPTEKEYWKQRWARESANPGSRCC
>NZ_CP038157.1|WP_144318371.1|2101559_2102576_-|3-isopropylmalate-dehydrogenase
MKIAVIAGDGIGTEVMAEGLKVLRAVRDDVETTEYDLGARRYLRNGELLTDVDLDSLRAHDAILLGAIGDPARVPAGVLERGLLLPLRFSLDHFVNLRPSRLYPTAVSPLANPGDIDFVVVREGTESLYAGSGGVLRANTPHEVACEVSQNTRFGVERVVRYAFELAMQRRKHLTLVHKTNVLVNAGGLWQKTVDAVAAEYPEVTVDYNHIDATTIYMVTDPQRYDVIVTDNLFGDIITDLAGAVTGGVGQACSGNIDASRTNPSMFEPVHGSAPDIAGKGIADPTAMILSVAMMLRWLGDASAAERIESAVAADVAAREAGPVSTTEVGDRIVAALK
>NZ_CP038157.1|WP_144318370.1|2100048_2101518_-|cell-wall-binding-repeat-containing-protein
MTTTFVRPRAVIAAAVTLPALFAGACGSGGTPAESPRLETSGPEVLSDADGTGIDVSRRLFESSDAVVVASPSRDAQLHGAAVAAELGAPLLVRAGGAEAAVDAEIQRLGAKRVIDVPGDDEVLAQTAPVASDSAESDVAAIAALEPANPVELQLPEMLATEETSLGAAATARAAGAQLDVLAVPDPRLTSESMRTVTGQDTLALGSQWGTTEEYAHRVELAAAGELPGGGGLVFPGRRMIALYGHSFAPELGVMGEQDPVAAAALATQYAQQYQPMEEQPVIPAFEIIVTVASEFPGEDGDYSNEAPLETVVPWIDAITEAGGYAVLDLQPGQGDFLHQAKLYEELLKRPNVGLALDSEWKLNPGEAPLSRVGSASAEEINVVADWLAQLVRENNLPQKAFVLHQFQVAMFPDRENIQTVHPELAYVLHADGHGSPGQKYDTWNVLREGLDPNFFMAWKNFIDEDQPMFTPEQTYLEVEPRPWFVSYQ
>NZ_CP038157.1|WP_136653499.1|2098176_2100039_-|cyclic-nucleotide-binding/CBS-domain-containing-protein
MTVELDEVRAFLADHEPFAHLPAETLDGLPQHMGITYVRRGQTVINYGDVNDTLYIIRSGAIDVVGPDNSLLDRRDVGRTFGYSTLVDDPRSRYMMAAVEDSVLYMLPRTPFRALVDAFPETLRYFDTASRRIKAAADELKEDSAASDVLRTPVGELVAGARLITVDGAATIAEGARLMDEHAISSLIVTGATEPGIVTDRDFRSRVVAKGVDTQAPLREVMTSPVRTIASDALVFEAMLVMGDLGTHHLPVTDGGEIIGVATSSDIMRQLKADPIYMAADVRKSSRAQLAGAYERGAVVAARFFDRGASAFESQRLLTGVADSIARRLYALAVAELGEPPVPFAFVAVGSQARGEMGPASDQDNALVLDDSFDAALHGDYFARLGDYICSGLAEAGQALCPGGIMAHNPQWRMTESQWNDTFHGWVTAPEPDALLNAQVFFDFRCIFSAFGGEQMAQRVHDNAVVAARGSKRLHTHLAALATWREPPIGFFRGFVVERSGEYADTLDVKKGGTAAVVQMARLYAITAGVGEVDTLARIRASAGSSVSVKGAEDLLGAYEYLTDLALKQQTRQLRRGERPNYHIDPKALPSRERDALRDAFGVIKNLQSALGNKYPVRSV
>NZ_CP038157.1|WP_144318377.1|2111751_2112768_-|ketol-acid-reductoisomerase
MAIEVFYDKDADLSLIQGKKVAVIGYGSQGHAHAQNLRESGVEVVIGLRDGSKSAEKAKEAGFEVKSNAEAAKWADVIMLLAPDTSQAEIFKNDIEPNLNDGDALFFGHGLNIHFKLIEPADNITVAMVAPKGPGHLVRRTFADGKGVPALIAVEQDPSGIGQALALSYAAAIGGARAGVIPTTFEAETVTDLFGEQAVLCGGLEQLIMNGFDVLTEAGYEPEMAYFECLHEIKLIVDLIYEGGIANMNYSVSDTAEFGGYLSGPRVVDEGSKERMRDVLKDIQSGEFTRRLVANVENGNTELEGLREKVSQHPIEKTGAELRDMMSWVKNPLTDTAQ
>NZ_CP038157.1|WP_136653521.1|2112854_2113370_-|acetolactate-synthase-small-subunit
MNKDETNRHILSVLVLDLDGIITRVTALFTRRGYNLVSLVSANTETEGVNRLTIVVDASEYHIEQITKQLHKLIQVLKVTRLDDANTIARSLLLVKVNADNSNRPQVVDAANIFRARVVDVAPESVVIEATGTPSKLRAFLDVMETFGIRELVSSGQVALNRGPKAMGTSK
>NZ_CP038157.1|WP_144318378.1|2113371_2115225_-|acetolactate-synthase-large-subunit
MAASKKPSPKARKPEEVSPERMTGADAVVRSLEALGTDIVFGLPGGAVLPLYESLFAAEKLRHVLVRHEQGAGHAATGYAQASGKVGVCIATSGPGATNLVTAIADAYLDSVPILAITGQVGSPLIGTDAFQEADIRGITMPITKHNVMVRSADEIPAAIAEAHHIASTGRPGPVLVDIPKDVQNEEFDFSWPPVLDLPGYKPNTKPHSRQIVQAARMIAQAERPVLYIGGGVLKAEAHEELLAFANETGVPVVTTLMALGVFPQSHPLYMGMPGMHGSVPAVGALQESDLLIAIGTRFDDRVTGDTDTFAPEAKTIHADIDPAEVGKIREVDVPIVGDAKRVLSQLTDAFKDGKASTPRIGAWIERLNELKERFPRGYDPQSDGSLSPQYVIETLSAEVGPDAIYVAGVGQHQMWSAQFIDFEKPRTWLNSGGLGTMGYAIPAALGAKAGAPDKEVWAIDGDGCFQMTNQEITTAAMEGFPFKVALINNGNLGMVRQWQTLFYGGHYSHTKLGGEVYVPDFVKLSDALGAEAIRVTTEEEVLPAIKRAREINDRPVVIEFIVGEDAQVWPMISAGSSNSDIQYAMNIRPFFDLEESAGEAPEDIDDVVEIETEKGN
>NZ_CP038157.1|WP_144318379.1|2115489_2116932_+|mechanosensitive-ion-channel
MPYAYIAEEAWRWVANTGINLALLIILAMLVPRAGRFANRVAERRADAQADNDEAKSQLAIAGVGIYIAQAIAFFLILVFFLQEVGFSLAGAAIPATVVSAAIGFGAQNIIADFLAGFFVLTEKQYGVGDFVTFEGNGIEVSGNVIQITMRATQIRTMEQSTISIPNSTARICINQSNYWASAVVVIPVPLLGSTSADEAVARSESAARRALNRADIRPKLLDDLTVHPAVDINPPATVGMPWTLDMRFIVRVEPLAQWMVERAIRLSVLNEFWEEYGSATTIEGTRLDHVVDHTEQFNSVDRYPPTEYMSPVSPLSTQRSDHDDLTPADPDEDPATDVLADDEKAMPRMAFGGALRLSTALLIGAFIILLIIRGLTLDPDGEDTGSGWLAPPPETPTSETEDPVEDSPTRAPAPAPTQTPTQSPAPAPSTAQPTAPRTPTPSPAETSTQGEPTQPPAPGVTEGASISEAPPAEAGNPLG
>NZ_CP038157.1|WP_136653528.1|2116941_2117460_+|PH-domain-containing-protein
MTDSPQVFRPSREHVLAIALMTGIALIGIAWAPLILGWLLIIPAAYLVWVFGSATKVDGSGIAVKYPVRPNATIAWEDLSGIAFKGARALATTTSGKEYPMPGVTFNSIPELALASGGRIQDVITASAEAADGKYEVIDREGRKVLLSREEYDEYLRDHPTTPGPRPDTTKE
>NZ_CP038157.1|WP_144318380.1|2117466_2119305_+|dihydroxy-acid-dehydratase
MIPLRSRVTTVGRQAAGARALWRATGTGEKEFGKPIVAIVNSYTQFVPGHVHLKNVGDIVAEAVRAAGGVPKEFNTIAVDDGIAMGHSGMLYSLPSREIISDSVEYMINAHTVDAMVCISNCDKITPGMLNAAMRLNIPAVFVSGGPMEAGKAFSVGGVTKPKSDLIDAISLSANDAVSDSELESIANAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHTARRALFEKAGEAIVKLCDRYYGEGDESVLPRSVATVDAFRNAMALDMAMGGSTNTILHILAAAQEGEVDFSLHDIDELSHSIPCLSKVAPNGEAHVEDVHRAGGIPAILGELNRAGLLNKNVHTVAYPSLDKWLADWDIRAESPLPEAIELYHAAPGGKRTTEAFSQSARWESLDTDSANGVIHDVEHSFTSDGGLVVLRGNIAPDGAILKTAGVEEGLWEFSGPARVLDSQEQAVSVILNREVQEGEVIVIRYEGPAGGPGMQEMLHPTSFLKGAGLGTKCALITDGRFSGGTSGLSIGHISPEAAHGGLIGLVENGDTISISVSNREIRLDVDEEVIAERRSMMEASERPWTPNRTREVTKALRAYAKMATSADKGAVRQVD
>NZ_CP038157.1|WP_144318381.1|2119315_2120647_+|DUF2029-domain-containing-protein
MKSHLLTFVTALAAVVSVAATVILMRATDFPVDVIIYREGARAFLEGRPVYSEPMYAADVALPFIYPPFGALVLTPLATVSWLSDDALGNVVIAISAAALLLCVYFVLCAVTRGRLGTRQFIALVAVAWAFGVCIEPMRLNAMYAQINVVIMTLVVLDVVPRKRWLPQGSLIGIAAAIKITPLAMLLFFLLRRDVRAILVAGASGLIATVVAALVRWDATREFFGATLLSMGTTSEFGVDTTYQSNSSLKGMVMRFYPSGESLAAHGLSSNLIWAGLSVATVVLGGWLMVTLIRRGMLIDAALANAVIMLLISPVSWSHHWVWLALILPVAWWRCATVLKWPVFLTAVVAVFTVTVIGVPPKWWFGDAIAVHELPLWAKILVSDYVWLGIALLAAWAAALRGVPELGERVDAGAEPPHQRGGGDAESGENPGRGERAARPAAS
>NZ_CP038157.1|WP_144318382.1|2120530_2121334_-|DoxX-family-membrane-protein
MTNNNFHDVTPDDFNGFEDVPTYAEGGSTSRIRPANTSDIYQRTGKAAPTEVFPSSISQPTEMIEPDYAAMPAPVAEPAYIEPAYVEEPVATAVDARRGTIDLGLLLLRFVLGGYLIFSAIQTFFQLGASQGIAGLEAQFGAYAYGNALAVIVPTLELAAGVFIVLGLLSPVASMVAIAVTGFMAAHTAANTGTGFNPVAWGADVWLAVILLGVALAHQFTGPGFYAVDSGRGWARRPLASSWIFAALGIAAAALMWWFGTGINPFA
>NZ_CP038157.1|WP_144318383.1|2121439_2122498_+|glutathione-S-transferase-C-terminal-domain-containing-protein
MDKSQWKNAPQNASTDGAFERDTTYIEDRIVADVDKQHTGKGELWPVESGRYRLMAARACPWAHRTIIARRLLGLEDAISLGLAGPTHDADSWVFDVDPGEKDPVTGLHKLKEAYENRFPDYPKGITVPAIVEVGTNKVVTNWFKQIPVDFNNEWTEFHREGTPDLYPEALREETDQVSNRVYKYVNNDVYRCGFAASQDAYEEAYYELWENMDWLEERLGQQRYLVGNQITLADIYLYPTLVRFDPVYYGHFKASRTKIAEMPNLRGYLQELFQLPGFGDTTDFTEIKQHYYITHAEVNPTGVVPLGPELGWLVEQHDRNRFGGSPYAEGVTAPRPVREGEEVKNPEPFQL
>NZ_CP038157.1|WP_144318384.1|2122587_2124009_+|hypothetical-protein
MRRAVKVALAFVGLLVGAGFASGQETIQYFLAFGYWGIVGTIVAGLVIVLVGTTLFQLGSYFLADDHSAVFKSVSHPVVARFMDVSTMITLFAIGFVMVAGAGSNLEQQFGFPTWAGAAIMTVALLASGFLDIDRLTNVISSITPFLILAVLGALVVTILNMPDNFSAINELAMQNAPASGVGNNWLLSALNYAAMCTIVAVSMILVIAGSQLNPREAGIGGLIGGIIFSTLQVILAFIIFANIEDVFGADLPLLMVFDNMHPAVGVVVALVIYLMIYNTAVGMFYAMARRMSATNHSRFRPIYFAVVLIGFALSFIGFADLLGWVYPILGYLGMVLIAVMVFVWFRDRTLIKNETQRRERLAALTEKALDPTERDLTDNQRAEVEELAAQSHVEENTLWQSVQEEVAATLDADPASEFSLEETPTLDPESKEYEGAPEPTTDAPIDWRAYDEVYKTGSFPAVRPADKAGQGD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP038157_1	1.2\|142720\|25\|NZ_CP038157\|CRISPRCasFinder	142720-142744	25	NZ_CP038157.1	2184394-2184418	0	1.0
NZ_CP038157_3	3.4\|1086011\|34\|NZ_CP038157\|PILER-CR	1086011-1086044	34	NZ_CP038157.1	1086064-1086097	2	0.941

1. spacer 1.2|142720|25|NZ_CP038157|CRISPRCasFinder matches to position: 2184394-2184418, mismatch: 0, identity: 1.0

tcccaggtggttttgcgaccctaac	CRISPR spacer
tcccaggtggttttgcgaccctaac	Protospacer
*************************

2. spacer 3.4|1086011|34|NZ_CP038157|PILER-CR matches to position: 1086064-1086097, mismatch: 2, identity: 0.941

cacctggggttttacaccgccgcaaccgttgacc	CRISPR spacer
cacctggggttttacacccccgcaaccgtcgacc	Protospacer
****************** **********.****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP038157_1	1.1\|142662\|23\|NZ_CP038157\|CRISPRCasFinder	142662-142684	23	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	404576-404598	3	0.87
NZ_CP038157_7	7.6\|1842991\|25\|NZ_CP038157\|CRT	1842991-1843015	25	NC_019789	Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence	321890-321914	3	0.88
NZ_CP038157_7	7.2\|1842796\|26\|NZ_CP038157\|CRT	1842796-1842821	26	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1560888-1560913	4	0.846
NZ_CP038157_7	7.6\|1842991\|25\|NZ_CP038157\|CRT	1842991-1843015	25	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1829193-1829217	4	0.84
NZ_CP038157_7	7.7\|1843034\|25\|NZ_CP038157\|CRT	1843034-1843058	25	NZ_CP041744	Paraburkholderia megapolitana strain LMG 23650 plasmid unnamed1, complete sequence	3976-4000	4	0.84
NZ_CP038157_7	7.13\|1842948\|27\|NZ_CP038157\|CRISPRCasFinder	1842948-1842974	27	NC_012849	Ralstonia pickettii 12D plasmid pRp12D02, complete sequence	156572-156598	4	0.852
NZ_CP038157_7	7.16\|1843142\|27\|NZ_CP038157\|CRISPRCasFinder	1843142-1843168	27	NC_012849	Ralstonia pickettii 12D plasmid pRp12D02, complete sequence	156572-156598	4	0.852
NZ_CP038157_7	7.2\|1842796\|26\|NZ_CP038157\|CRT	1842796-1842821	26	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	2353481-2353506	5	0.808
NZ_CP038157_7	7.2\|1842796\|26\|NZ_CP038157\|CRT	1842796-1842821	26	NC_017311	Desulfovibrio vulgaris RCH1 plasmid pDEVAL01, complete sequence	118482-118507	5	0.808
NZ_CP038157_7	7.2\|1842796\|26\|NZ_CP038157\|CRT	1842796-1842821	26	NC_005863	Desulfovibrio vulgaris str. Hildenborough plasmid pDV, complete sequence	123925-123950	5	0.808
NZ_CP038157_7	7.2\|1842796\|26\|NZ_CP038157\|CRT	1842796-1842821	26	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1273829-1273854	5	0.808
NZ_CP038157_7	7.2\|1842796\|26\|NZ_CP038157\|CRT	1842796-1842821	26	NC_008741	Desulfovibrio vulgaris DP4 plasmid pDVUL01, complete sequence	79905-79930	5	0.808
NZ_CP038157_7	7.6\|1842991\|25\|NZ_CP038157\|CRT	1842991-1843015	25	NC_019313	Sinorhizobium meliloti plasmid pHRC017, complete sequence	260884-260908	5	0.8

1. spacer 1.1|142662|23|NZ_CP038157|CRISPRCasFinder matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 3, identity: 0.87

gccgaaacgcgccccggcaccag	CRISPR spacer
accgaatcgcgccccggcaccac	Protospacer
.***** ***************

2. spacer 7.6|1842991|25|NZ_CP038157|CRT matches to NC_019789 (Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence) position: , mismatch: 3, identity: 0.88

ttgcgggcgagcttcaagtcgtggg	CRISPR spacer
tggcgggcgagctccaagtcgtggt	Protospacer
* ***********.**********

3. spacer 7.2|1842796|26|NZ_CP038157|CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 4, identity: 0.846

ctgcgggtcgcgcttcaagtcgtggg	CRISPR spacer
ccgcgggtcccgcttcaaatcgtggt	Protospacer
*.******* ********.******

4. spacer 7.6|1842991|25|NZ_CP038157|CRT matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 4, identity: 0.84

ttgcgggcgagcttcaagtcgtggg	CRISPR spacer
gtgcgggcgagcttcgcgtcgtggt	Protospacer
 **************. *******

5. spacer 7.7|1843034|25|NZ_CP038157|CRT matches to NZ_CP041744 (Paraburkholderia megapolitana strain LMG 23650 plasmid unnamed1, complete sequence) position: , mismatch: 4, identity: 0.84

gtaaacgccgcgcttcatccctggg	CRISPR spacer
aaaaacgcggcgcttcgtccctggg	Protospacer
. ****** *******.********

6. spacer 7.13|1842948|27|NZ_CP038157|CRISPRCasFinder matches to NC_012849 (Ralstonia pickettii 12D plasmid pRp12D02, complete sequence) position: , mismatch: 4, identity: 0.852

cttggggcgtgacttggtttgcggcga	CRISPR spacer
ctgccggcgtggcttggtttgcggcga	Protospacer
**   ******.***************

7. spacer 7.16|1843142|27|NZ_CP038157|CRISPRCasFinder matches to NC_012849 (Ralstonia pickettii 12D plasmid pRp12D02, complete sequence) position: , mismatch: 4, identity: 0.852

cttggggcgtgacttggtttgcggcga	CRISPR spacer
ctgccggcgtggcttggtttgcggcga	Protospacer
**   ******.***************

8. spacer 7.2|1842796|26|NZ_CP038157|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 5, identity: 0.808

ctgcgggtcgcgcttcaagtcgtggg	CRISPR spacer
gcgcgggtcgcgcttcacggcgtggt	Protospacer
 .*************** * *****

9. spacer 7.2|1842796|26|NZ_CP038157|CRT matches to NC_017311 (Desulfovibrio vulgaris RCH1 plasmid pDEVAL01, complete sequence) position: , mismatch: 5, identity: 0.808

ctgcgggtcgcgcttcaagtcgtggg	CRISPR spacer
gcgcgggtcgcgcttcacggcgtggt	Protospacer
 .*************** * *****

10. spacer 7.2|1842796|26|NZ_CP038157|CRT matches to NC_005863 (Desulfovibrio vulgaris str. Hildenborough plasmid pDV, complete sequence) position: , mismatch: 5, identity: 0.808

ctgcgggtcgcgcttcaagtcgtggg	CRISPR spacer
gcgcgggtcgcgcttcacggcgtggt	Protospacer
 .*************** * *****

11. spacer 7.2|1842796|26|NZ_CP038157|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 5, identity: 0.808

ctgcgggtcgcgcttcaagtcgtggg	CRISPR spacer
gcgcgggtcgcgcttcacggcgtggt	Protospacer
 .*************** * *****

12. spacer 7.2|1842796|26|NZ_CP038157|CRT matches to NC_008741 (Desulfovibrio vulgaris DP4 plasmid pDVUL01, complete sequence) position: , mismatch: 5, identity: 0.808

ctgcgggtcgcgcttcaagtcgtggg	CRISPR spacer
gcgcgggtcgcgcttcacggcgtggt	Protospacer
 .*************** * *****

13. spacer 7.6|1842991|25|NZ_CP038157|CRT matches to NC_019313 (Sinorhizobium meliloti plasmid pHRC017, complete sequence) position: , mismatch: 5, identity: 0.8

ttgcgggcgagcttcaagtcgtggg	CRISPR spacer
ttgcgggcgagcttcaaggcggctt	Protospacer
****************** **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

141436 : 160515

Mycobacterium_phage(33.33%)

transposase,integrase

attL 152238:152297|attR 157800:158900

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_136648868.1\|141436_142624_-\|transposase	IS481 family transposase	A8RHK4	Spiroplasma_virus	1.5e-05	29.0
WP_144317253.1\|143610_145575_+	N-6 DNA methylase	A0A220A2U4	Liberibacter_phage	7.1e-32	27.3
WP_144317254.1\|145571_146834_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_144317255.1\|146830_150022_+	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_144317256.1\|150194_150374_+	hypothetical protein	NA	NA	NA	NA
WP_144317257.1\|150481_151642_+	hypothetical protein	NA	NA	NA	NA
WP_144317258.1\|151641_152127_+	hypothetical protein	NA	NA	NA	NA
152238:152297	attL	NA	NA	NA	NA
WP_144317259.1\|152277_152607_-\|transposase	transposase	A0A2P1JR32	Mycobacterium_phage	1.3e-26	67.0
WP_144317260.1\|152587_154006_-\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	1.0e-32	36.3
WP_144317261.1\|155103_155385_+	hypothetical protein	A0A2P1JR43	Mycobacterium_phage	7.5e-12	49.5
WP_144317262.1\|155387_156758_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	Q6H9S3	Enterobacteria_phage	2.4e-31	39.7
WP_170228596.1\|156768_157509_+\|transposase	IS30 family transposase	W5R8L2	Staphylococcus_phage	5.0e-31	38.1
WP_144317259.1\|157489_157819_+\|transposase	transposase	A0A2P1JR32	Mycobacterium_phage	1.3e-26	67.0
WP_144317263.1\|158283_159684_+	GntP family permease	NA	NA	NA	NA
157800:158900	attR	NA	NA	NA	NA
WP_144317264.1\|159696_160515_+	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0N7HVJ8	Ostreococcus_lucimarinus_virus	5.0e-32	31.1

DBSCAN-SWA_2

190495 : 220959

Streptococcus_phage(22.22%)

transposase,integrase

attL 189370:189398|attR 219231:219259

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
189370:189398	attL	NA	NA	NA	NA
WP_144317273.1\|190495_191845_-\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	6.1e-35	36.6
WP_144317274.1\|191862_192282_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_144317275.1\|192318_192588_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_144317276.1\|193079_193730_-	vitamin K epoxide reductase family protein	NA	NA	NA	NA
WP_144317277.1\|193739_194447_-	thioredoxin domain-containing protein	NA	NA	NA	NA
WP_144317278.1\|194548_194881_-	metalloregulator ArsR/SmtB family transcription factor	NA	NA	NA	NA
WP_144317279.1\|195025_195817_-	peptidoglycan DD-metalloendopeptidase family protein	W8ED04	Mycobacterium_phage	2.5e-20	46.8
WP_144317280.1\|196158_198315_-	cytochrome c oxidase assembly protein	NA	NA	NA	NA
WP_040423188.1\|198573_199164_+	copper resistance protein CopC	NA	NA	NA	NA
WP_144318556.1\|199521_199998_-	sensor histidine kinase	W8CYF6	Bacillus_phage	8.8e-13	36.6
WP_006841222.1\|200088_201120_+	c-type cytochrome biogenesis protein CcsB	NA	NA	NA	NA
WP_006841223.1\|201177_202848_-	thiol reductant ABC exporter subunit CydC	G9BWD6	Planktothrix_phage	2.5e-06	29.1
WP_144317281.1\|202874_204479_-	ATP-binding cassette domain-containing protein	NA	NA	NA	NA
WP_136652913.1\|204484_205486_-	cytochrome d ubiquinol oxidase subunit II	NA	NA	NA	NA
WP_006841226.1\|205488_207114_-	cytochrome ubiquinol oxidase subunit I	NA	NA	NA	NA
WP_006841228.1\|208687_209053_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_144317282.1\|209085_211020_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	9.5e-90	36.8
WP_006841231.1\|212249_214337_+	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.0e-113	39.5
WP_144317283.1\|214625_215717_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_003860198.1\|216144_216465_-\|transposase	transposase	Q8W6R2	Burkholderia_virus	3.0e-17	51.7
WP_144317284.1\|216451_216745_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	Q8W6R2	Burkholderia_virus	2.1e-12	40.2
WP_144317271.1\|216781_217579_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	1.8e-47	41.9
WP_136649175.1\|217622_218825_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_136651714.1\|219750_220959_-\|transposase	IS21 family transposase	NA	NA	NA	NA
219231:219259	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP038157

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection