CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP036260	Sporomusa termitida strain DSM 4440 plasmid pSPTER, complete sequence	0 crisprs	NA	0	0	1	0
NZ_CP036259	Sporomusa termitida strain DSM 4440 chromosome, complete genome	15 crisprs	PD-DExK,cas10,csm3gr7,csx10gr5,csx19,cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2,csa3,RT,DEDDh,cas7,cas8c,DinG,WYL,cas3HD	1	6	6	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

27837 : 55181

Paenibacillus_phage(60.0%)

protease,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_170233413.1\|27837_28725_+\|transposase	transposase	NA	NA	NA	NA
WP_170233414.1\|29207_29897_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	5.1e-46	42.0
WP_144353097.1\|29902_30202_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_144353098.1\|30198_30558_+	hypothetical protein	A0A0C5AEA5	Paenibacillus_phage	3.3e-28	68.1
WP_170233415.1\|30554_30785_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	1.8e-19	56.6
WP_144353172.1\|31106_33254_-	TonB-dependent receptor	A0A0P0I887	Acinetobacter_phage	2.6e-11	32.1
WP_144353173.1\|34010_34679_+	class D beta-lactamase	NA	NA	NA	NA
WP_144353100.1\|34709_34916_+	GrpB family protein	NA	NA	NA	NA
WP_144353101.1\|34942_35251_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_144353102.1\|35253_35574_+	TfoX/Sxy family protein	NA	NA	NA	NA
WP_144353103.1\|37354_37534_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_144353104.1\|37760_38078_-	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_144353105.1\|38131_38479_+	hypothetical protein	NA	NA	NA	NA
WP_144353106.1\|39910_40354_+	OmpH family outer membrane protein	NA	NA	NA	NA
WP_170233416.1\|40431_45762_+	TonB-dependent receptor	NA	NA	NA	NA
WP_170233417.1\|45896_47231_+	hypothetical protein	NA	NA	NA	NA
WP_144353109.1\|47379_47997_+	hypothetical protein	NA	NA	NA	NA
WP_144353110.1\|48071_49691_+	hypothetical protein	NA	NA	NA	NA
WP_170233418.1\|50005_50176_+	hypothetical protein	NA	NA	NA	NA
WP_144353111.1\|50194_51094_+\|protease	cysteine protease	A0A2K9L9R4	Tupanvirus	4.7e-31	35.7
WP_144353112.1\|51228_52395_+	hypothetical protein	NA	NA	NA	NA
WP_144353113.1\|52601_53063_+	VOC family protein	NA	NA	NA	NA
WP_144353174.1\|53246_53495_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
WP_170233419.1\|53638_53938_-	hypothetical protein	NA	NA	NA	NA
WP_170233420.1\|53918_54311_-	hypothetical protein	NA	NA	NA	NA
WP_144353116.1\|54416_55181_-\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP036259

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP036259_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_1

143788-144215

TypeIII

Consensus_repeat	Method
GTTTTTAGGCTACCTATGAGGATTTGAAAC	PILER-CR
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CRISPRCasFinder
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CRT

6 spacers

RT,PD-DExK,cas10,csm3gr7,csx10gr5,csx19

The CRISPR arrays of NZ_CP036259_1

>merge|NZ_CP036259|1|143788-144215|PILER-CR,CRISPRCasFinder,CRT
GTTTTTAGGCTACCTATGAGGATTTGAAACATTAAACCAGCAGAAACGGTAATTACATTGTCACCCGTTTTTAGGCTACCTATGAGGATTTGAAACATACGTATGCAACTCTAAAAATAGATCATCTGGAAGTTTTTAGGCTACCTATGAGGATTTGAAACTTATGGATTCCAACTATGCGCAACGAAGCGAATTAGGAGTTTTTAGGCTACCTATGAGGATTTGAAACCCGATATAGGGCATCCGCAGCAGCCTGTGCGCGTCAGGTTTTTAGGCTACCTATGAGGATTTGAAACCTGTAGTAAATCACTATGGTCTGCCATGTGTTTTACCGTTTTTAGGCTACCTATGAGGATTTGAAACGCAAACACGTCAGATATTTCATTTTGAGTGAGTCCGTCTTTAGGCTACCTATAAGGACTTGAAAT

>NZ_CP036259|1|1|143788-144150|PILER-CR
GTTTTTAGGCTACCTATGAGGATTTGAAAC	ATTAAACCAGCAGAAACGGTAATTACATTGTCACCC
GTTTTTAGGCTACCTATGAGGATTTGAAAC	ATACGTATGCAACTCTAAAAATAGATCATCTGGAA
GTTTTTAGGCTACCTATGAGGATTTGAAAC	TTATGGATTCCAACTATGCGCAACGAAGCGAATTAGGA
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CCGATATAGGGCATCCGCAGCAGCCTGTGCGCGTCAG
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CTGTAGTAAATCACTATGGTCTGCCATGTGTTTTACC
GTTTTTAGGCTACCTATGAGGATTTGAAAC

>NZ_CP036259|1|1|143788-144215|CRISPRCasFinder
GTTTTTAGGCTACCTATGAGGATTTGAAAC	ATTAAACCAGCAGAAACGGTAATTACATTGTCACCC
GTTTTTAGGCTACCTATGAGGATTTGAAAC	ATACGTATGCAACTCTAAAAATAGATCATCTGGAA
GTTTTTAGGCTACCTATGAGGATTTGAAAC	TTATGGATTCCAACTATGCGCAACGAAGCGAATTAGGA
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CCGATATAGGGCATCCGCAGCAGCCTGTGCGCGTCAG
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CTGTAGTAAATCACTATGGTCTGCCATGTGTTTTACC
GTTTTTAGGCTACCTATGAGGATTTGAAAC	GCAAACACGTCAGATATTTCATTTTGAGTGAGTCC
GTCTTTAGGCTACCTATAAGGACTTGAAAT

>NZ_CP036259|1|1|143788-144215|CRT
GTTTTTAGGCTACCTATGAGGATTTGAAAC	ATTAAACCAGCAGAAACGGTAATTACATTGTCACCC
GTTTTTAGGCTACCTATGAGGATTTGAAAC	ATACGTATGCAACTCTAAAAATAGATCATCTGGAA
GTTTTTAGGCTACCTATGAGGATTTGAAAC	TTATGGATTCCAACTATGCGCAACGAAGCGAATTAGGA
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CCGATATAGGGCATCCGCAGCAGCCTGTGCGCGTCAG
GTTTTTAGGCTACCTATGAGGATTTGAAAC	CTGTAGTAAATCACTATGGTCTGCCATGTGTTTTACC
GTTTTTAGGCTACCTATGAGGATTTGAAAC	GCAAACACGTCAGATATTTCATTTTGAGTGAGTCC
GTCTTTAGGCTACCTATAAGGACTTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144348616.1\|149192_150005_+\|hypothetical-protein	csm3gr7	pfam03787_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187857
NZ_CP036259.1\|WP_170233084.1\|150001_150643_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377130
NZ_CP036259.1\|WP_144348620.1\|154298_155105_+\|MetQ/NlpA-family-lipoprotein	unknown	unknown	gnl\|CDD\|224381
NZ_CP036259.1\|WP_144352680.1\|144348_145293_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP036259.1\|WP_144348618.1\|150639_151071_+\|hypothetical-protein	csx19	mkCas0132_csx19_CAS-III-D	unknown
NZ_CP036259.1\|WP_144348619.1\|151057_153358_+\|hypothetical-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP036259.1\|WP_144352679.1\|133487_133709_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP036259.1\|WP_144348612.1\|141850_142261_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348615.1\|147562_149215_+\|hypothetical-protein	csx10gr5	cls000715_csx10gr5_CAS-III-D	gnl\|CDD\|131722
NZ_CP036259.1\|WP_170233082.1\|133254_133458_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348607.1\|135254_136382_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348610.1\|139395_140631_+\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP036259.1\|WP_144348621.1\|155239_155791_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|319885
NZ_CP036259.1\|WP_144348609.1\|137340_138837_+\|Nramp-family-divalent-metal-transporter	unknown	unknown	gnl\|CDD\|224826
NZ_CP036259.1\|WP_144348613.1\|145316_146900_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209
NZ_CP036259.1\|WP_144348614.1\|146856_147585_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	unknown
NZ_CP036259.1\|WP_170233083.1\|140957_141707_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP036259.1\|WP_144348606.1\|134880_135090_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224393
NZ_CP036259.1\|WP_144348605.1\|134089_134734_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224885
NZ_CP036259.1\|WP_144348608.1\|136803_137307_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144348616.1\|149192_150005_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	9.03159e-12
NZ_CP036259.1\|WP_170233084.1\|150001_150643_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	3.03981e-10
NZ_CP036259.1\|WP_144348613.1\|145316_146900_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	1.14597e-05
NZ_CP036259.1\|WP_144352679.1\|133487_133709_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.68801e-16
NZ_CP036259.1\|WP_144348621.1\|155239_155791_+\|4Fe-4S-binding-protein	gnl\|CDD\|319885	cd10563, CooF_like, CooF, iron-sulfur subunit of carbon monoxide dehydrogenase. This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.	2.36984e-62
NZ_CP036259.1\|WP_144348605.1\|134089_134734_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	1.2812e-26
NZ_CP036259.1\|WP_144348620.1\|154298_155105_+\|MetQ/NlpA-family-lipoprotein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.24881e-129
NZ_CP036259.1\|WP_144348610.1\|139395_140631_+\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	2.89631e-176
NZ_CP036259.1\|WP_144348609.1\|137340_138837_+\|Nramp-family-divalent-metal-transporter	gnl\|CDD\|224826	COG1914, MntH, Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].	1.25048e-07
NZ_CP036259.1\|WP_144348619.1\|151057_153358_+\|hypothetical-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	2.45654e-30
NZ_CP036259.1\|WP_144348606.1\|134880_135090_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	1.8039e-06
NZ_CP036259.1\|WP_170233083.1\|140957_141707_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	8.98276e-63
NZ_CP036259.1\|WP_144348615.1\|147562_149215_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	4.14858e-12

>NZ_CP036259.1|WP_144348612.1|141850_142261_-|hypothetical-protein
MGHEKTTRLRPTVHTALAAGVRQQAGDAGDGLKSVLAQTFDQYVFTRVDHILSLAEADDDGYRQTVKDASNALDRLLALARRLKTQQPEMLGLVMDFESWAGLESGKAAEIAYRQGLRDSSQLRQEFMAYLQQQQD
>NZ_CP036259.1|WP_170233083.1|140957_141707_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MESEGSRRQNSGLTNRNHIKGRTRLGKIATQIKAQNYPKVCSVPLLLAVQADQPWYTLQDLVESAQKRPGQVKFGNVGMGSFPHILVEMINREAGINIAQVPFSGGGETVSALLGGHVQLILVNPVSIKEHVKNGTVRILAVTGERRIADPVFAQVLTFKEQGFDITVNNWHGIAIPKETPVAIKNKLAAGIKAIIDDPEFQANMERVGNQVEYLGPQESTDKWIADSQKLQKTLQESGIMEQIKAQKK
>NZ_CP036259.1|WP_144348610.1|139395_140631_+|group-II-intron-reverse-transcriptase/maturase
MDKTKSFVIPREAVKQAYEQVKANKGSAGVDGQSIEGFEENLYKLWNRMSSGSYFPPPVRAVEIPKKSGGKRMLGIPSVSDRIAQMVVKIYLEPMVEPHFCQDSYGYRPGKSAIDAIAITRQRCWKYDWVLEYDIKALFDAIDHELLMRAVTRHTDCKWIILYIRRWLASPFQTRDGKIMVRKAGTPQGGVISPVLANLFLHYAFDKWMARNNPQNPWARYADDGIIHCKTKEEAEKLLNKLDQRFRECGLELHPDKTKIIYCKDNKRTGNNQEITFDFLGYTFRPRSAQTREGERFLNFLPAVSRKASKAMHQTIRGWKLHRKTDKELADIAKVVNPVIRGWVNYYGRFYRSAMYPILRKLNQSLIRWVAKKYKRVNGRQKQAQNWLAKIAQCEPSLFSHWQMGIIPMIR
>NZ_CP036259.1|WP_144348609.1|137340_138837_+|Nramp-family-divalent-metal-transporter
MPDTKIVINPRPANPVTPASANDPKEALFSYPEPDKKLLLGWRGLLGFLGPGIILASATVGSGEVFFAPRGAAIFGYSILWCLLLGALSKGFMSYTGTRYIVLTSEHPITRWGRIFPGPKNWFPILLGVLAVLSMPSWVGGVANLLANMMMYLTNGALSVPIWATIYIVGTLAIVASGTYQHVETTQTYIVIAKVITSFVALFAVNPDWGQLLLGLIPNMPTYEPWIATKYPEIASRSIGMEMVAYVGAIGGGTYDYIGYVGLYRNKGWGAMGLPNQKEIEEKLHIIEGQFPLPTSKGEIAKAKTWLKAAQIDTIVSFGTLLLITVVFTALGSAVLHTQQLIPSGMKLLEHQSAFLTVIHPGLVYLYWLAVWCALWGVLSSIYELYPSTVYEAFRPASSWVREKGKTGVAKYVWIYMSLGGLAYNWAGFNVVTIVMVGSILGGALSCGLWCLAQIYAERKVLPPEYRMSSWVVVCVALSGIFLIAMAVFSVLDQFKLV
>NZ_CP036259.1|WP_144348608.1|136803_137307_+|hypothetical-protein
MIFKTISERLKGQPQGQIAARSIAITGFATLTAMAVLEKNVVFAPLFFLLCLYYLRKLLSKKPHFPKDPSMSSRPVSSSAETKEELLHMLGYYRKLLNSWKWIAVFGWVLSLCLLIYARSIVVILPIGLACYSTYALFRCHQAVHLIVTSPSMMERREEGKRLRRQH
>NZ_CP036259.1|WP_144348607.1|135254_136382_+|hypothetical-protein
MPKGDLDTMAWPALNYLYGAVPAGNYLHTIDYAGGAIVTVAMAGNAFAEAGTMPFPAYFNASEGPDRPPLAPAGQQHNGVALLKVGNSLLALFTSVDEPWGAAAYQASTLVRLRIEPTTGALSYTAGDYVKVGKNALALEPFAFTFNNGDYNNIYVPCIGGPQHFGRHNPDSRLDIVDLSTMTARTVFQAGPAGSTSDQLDFRDIVIGNRGDTYILAGRYNEDYATFRGRVYKTTAAVLQLQVNSSPAPALLSQLTEAVDEMAAAPGFLWALLYENALPVNNDRLWFVRGNQIDIYNPPPASLKDAPCRTLRPAADLGFANINSVTPLWQPPLIRSTQHQASRSLAAQARLAWQARAAALKARGELRTDAENKSV
>NZ_CP036259.1|WP_144348606.1|134880_135090_+|helix-turn-helix-domain-containing-protein
MRTKLIEFRSGRTQAEMGARYGVSQQSWSYWERGVKCPCPFIMKKIADDAGVPMEIIFGDVFNNRKLLK
>NZ_CP036259.1|WP_144348605.1|134089_134734_-|helix-turn-helix-domain-containing-protein
MLAAIIKAERTKKGLTQEELSKIVGVTQQAVAKWEAGKAMPDTALIPTLAALFDIPLSRLFGVEETGKLPAIPLNADDQPAFYRVPVIGRIPAGCPVLALESFESYEDIPGSWLSNHPEEFFILRVVGDSMEGARIFDGDKALIRKQSCFDNGQICAVGIAGDEEEYATLKYVYDLDEQFVELVPDNPKYRRKKVARGKVRIYGLLTMTYRQHN
>NZ_CP036259.1|WP_144352679.1|133487_133709_-|helix-turn-helix-domain-containing-protein
MFFSDRLKTLRNKHKINQTVLANLLNVSQRQISYYENGKDTPPLPALITLADYFGVSLDYLVGRSDEAQSNRK
>NZ_CP036259.1|WP_170233082.1|133254_133458_-|hypothetical-protein
MKKEHGHLTTMVTVYYKPFRFSPRWTPLPDGSHFKPIKEFHRLDFAHAGQTPKDAVAKRCLLAFGLI
>NZ_CP036259.1|WP_144352680.1|144348_145293_+|hypothetical-protein
MSGREVFEKIYENYQDLNRKMVNELKLSSIQGGLTGHCREEMWLKFFRDIIPQKFSLSQGVIIIDSYGNASREVDIAVYDEQYTPYVFRYNTLKFIPIEAVAVVIECKSVKPGSTQLTKWVERIDALRTCQAGIARIATGYVMGLNNRIQTGTRPIKILACLQKGYGTKKLQQAFDFIITRKKDEAVHFQLNVANKRKSLGWWGQQLNCTGSADNDSQCLVLKEAAISNNDPDSWQGLNFTNESNEINNTLADLEIEDNPVLSLNLQLNQLLMLINNPMLFPHFAYARQFNKIAGIIKEKRRKQPHCEVEQNDA
>NZ_CP036259.1|WP_144348613.1|145316_146900_+|hypothetical-protein
MAVYAYIDVARKQEFIYKNNKLRDNLHNSFIIKAITEELDQPERPEGFCLSAYLEQAHPGQFTFVYSGGGNSIIRFASPDIAEVFVKNFSREVLCRHPDLELYISLVGDDEVPDRCPGNDKQLLEKLHRAADKQKNRRRSRFRRWTYGVEKIDETGQAVRREAKSSPETKAAREYLKEKFQALVSSQHFVVTTELKDYQKAEEGKSYIGVIALDGNKMGEMVAGAGCFAEIKELSTTIEAIYKEAVREALCTCAASFREQGRPICITPVLMAGDDICLIAEAEHAIAIAAAILQSIQTVSGRQKQNNALLGRVIAGGYLTACAGVAIARYHYPFFELVQAAEGLCSRAKEGLYHVPAGNGSFIDWEVLQGPVPVAQPYKQCRRPGPVKEIFHVKPLRVDRSEPAAPVTVQGICHYDAFIDFLRNVRKHVSTSLLAECRKHFYCGWEPYRLFFESHRDSGKLTELAERIFGSHAGVWEHAVLTTAQEGVPFSRTYILPDILEISPFIAVQEEEAYGGNNLSDRGAASQ
>NZ_CP036259.1|WP_144348614.1|146856_147585_+|hypothetical-protein
MAETTYQIEVRLRSEAIFSSGEKESNQVQDRVLTDRYGLVYLHAKTLKGQLKRQAFWLLERYRSFDQARAQAFLKAMAVLFGMNGEEASLTGLSPDRRLLYQPGIMQLGHLALDERLRQYLIGLQDGGGEGLLGPLDLIEAQTHIRTGIQLEEGTAKEGRLTTYHTVKPGLTFYATVRFTADPEPYLDDLQRIICSLKRLGAGIHRGRGLVDSRLLLNGQSVPFTSGKGRETEVHHGMLSGY
>NZ_CP036259.1|WP_144348615.1|147562_149215_+|hypothetical-protein
MECYLVIEIINQEPLKIGAGGSKASQREPAKDYIPGSTIRGAFIGRLKQQGLFASAWQDILLKAACHNAYPYRNGRLYLPAPQHLRLNKHDWRRQKALGDQTAQRAAVVQLAAGPAKDRKNTLPYRFLATYDGVSLSGLQVAKEYRLHHNTSRNPDREERDNLFRYEAIAAGQVFRTVFRCDQVLAPLLPAVFPEEETTIYLGGSKSSGYGLCRWKKIDDVRERYQDIKPLLGLPAQDRPQAPGQELWLTCLSDVLVRNRYGQPENDIPAAYIESISGEPVSPAEHFVHTGISEGYNATWQARYPKETTIKAGSVLHYTFDRELPGEQLQAIADQLEGRLVGERTQDGFGWLGVNLFYPEALQIAEQAAEKEPDSSGVQASWRQLAAAMEENEHVRNTWKLLAAGLDRAKKRWLQKIFLTDEQTQEPAADRFLLSPQLKRHHLQNMNQRLNRRDSSPDRPYMQDSRLCSIADCPFIAVLAYVTGAENAKLACYGQRYLQTASGQLFYAGESETAAPGSDKQRERKFILELLAMGLAIRIGRKTDVAKADF
>NZ_CP036259.1|WP_144348616.1|149192_150005_+|hypothetical-protein
MWQRLIFEFAIRAVSPVRCGAVESEVVKDPNGKPVLLGNSLGGALRDYLRQGGVGKEAIEKIMGGEGEPGNRKGFKPSSIHISDGTVENYADEESDPLPRRQGTKINPVYGAAEQNQKYELEYLPAGTTVSFTIESDVWAGHEAKAGLQLRELEKVVATWANGFAGGAIVLGGRKSNGFGRFTLDSLQKRVFSLSSSQALDRFIFDGDESRPRRRCSGRRCRTIPCCPGEPLLSLCRASFPTACTRLFPWRIRMQAPGRWVPGADRLPVC
>NZ_CP036259.1|WP_170233084.1|150001_150643_+|hypothetical-protein
MKKRDRANGGRTAGAEYYIPAASLKGVLRHEVRRLLGRMAHAAPAMAADQLPGKIEKHLADLFGSTDSTGKLTVHDIVVTGTPVTVARDSSQTDQPVYTKIDRLTGGSYVSALKRQQEIQGTAVISLELAVKPAADGYFHYIFPLVYVLRRLGAELVPLGGRTVAGLGQFKAPTVNIDCGGETWNIETGPDLSAGNRRQLEVWWEAFAGWCRQ
>NZ_CP036259.1|WP_144348618.1|150639_151071_+|hypothetical-protein
MNELAAFDITRLAMDDDYYFIAHTLDCVLLGRPGESDHRRLLAAIQNGTLLEAHFFNAAGEIFVTRSQDRLVQYEPLLHDRNGFAAGEVIAREYELEEKFRQQSGYHSLTVKEYIKYDEDHLAYVEKTVLFTLNKAGDAHGGK
>NZ_CP036259.1|WP_144348619.1|151057_153358_+|hypothetical-protein
MAENRRGSRAGKADKLLPYDFVPFAETAYYPYQKPGTENRPDGRGGDLPGHDCRQNDKLSGFIEYTLTPYSDLALEIRQRLGGGYFMSGSQIRGRVRANLEILSASYPEFIDTTPLLYRDLTGKHSKDYRERINPDSEQRGIEYAVQAGFLVKEDDAFYIIPAPKIGEKYFLSIKEHRLLQMGMAQPGKCFRSLYCWEPEMLERFRQLQEQIDAFTKTIKMLRARLKSALQPIEGKIADKFRSNYGFQQRLKNILYDIRAKKNYSLPDELAGFKRKLLAELRPVGGQGNVEEFFQKLVDRWGLKAELYISYQQLRKNRDFRPYQQKVFLQKDENQGIIKISYQTGPEPAYLFNSTNASSKRSHYLVLAPGNSGSLPESYKVPAHVIAAYRRNLDKFRQTDKNTSVKEFYNIFEKYDEVCRQNNALAGLIVFFQQEQGEVRHVGRTPYFKIPYRHQLTTLLGRREPEKVDYAGALFGFVAEKTAAEPAERQAQAGLITAYKSRLRFTPVDIEPGDTQTPDLHKPPLQPFLLPTPRASACAMYLEQPAGGDLQTYEQLERPRLNGYKYYHIFPPTLKKGKPENWLNPGMLSNKPIIQRDSVKLLRGKIYFHNLTQAELGLLLLSLEPKQLLKTRQYGPQAEQYRCELEQAYDLIGGAKPYGYGKVKIEVRKLELEKSGCDFASLVLDTEEIIAAGTWGEYIDTFIAGMGGSKYFDTVHFRQYLQSKLELPDDNELITWDQLPTKIAEEKSSQVGYPKHWRLQRIGKKH
>NZ_CP036259.1|WP_144348620.1|154298_155105_+|MetQ/NlpA-family-lipoprotein
MKKLLALYLVIIAALFLGGCGSAEAPQQEAKILKVGVTSGPHAEILEQVKTVAERDGLKIEIVEFNDYVQPNTSLDQGEIDANAFQHQPFLDNHVKDRGYKLVSIAKTVILPMGIYSDKVKKLDELKDGSAVAIPNDPSNAGRALLLLDQAGLIKLKPGVGAAASVLDIVENPKNLKIKELEAALIPRAIADVDIAAINTSYALKAGLVPARDGLALENSSSPYTNVLAVREKDKDNPVFQKLIKAYHSEEVKKYLVEHFQGSILPGW
>NZ_CP036259.1|WP_144348621.1|155239_155791_+|4Fe-4S-binding-protein
MKRIWIDREKCLGCKSCELQCAIERDSVSKTLLGAVQETPKPMARVSVAGRTGRSFPLQCRQCQDAPCSRACPAGALQREPGTEVIFLDQAKCRGCWMCVMSCPFGVIVPSDTYKVAVKCDACIHREEPACVNACPTGALSQGDSADFQKILLKKRGRLALFALQNAEPGQVSLEFAGEDDKL

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Crispr_ID: NZ_CP036259_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_2

153653-154075

TypeIII

Consensus_repeat	Method
GATTTTAGGCTACCTATAAGGAATTGAAAC	PILER-CR
GATTTTAGGCTACCTATAAGGAATTGAAAC	CRISPRCasFinder
GATTTTAGGCTACCTATAAGGAATTGAAANC	CRT

6 spacers

csm3gr7,csx19,csx10gr5,cas10,PD-DExK

The CRISPR arrays of NZ_CP036259_2

>merge|NZ_CP036259|2|153653-154075|PILER-CR,CRISPRCasFinder,CRT
GATTTTAGGCTACCTATAAGGAATTGAAACGACTTACCCGGCTTATGAAGACACGATAACACAAGTCGATTTTAGGCTACCTATAAGGAATTGAAACCTGCGTCACCCTCTTTTGCATCCGGCAGGGCCAGGATTTTAGGCTACCTATAAGGAATTGAAACCCGGACTGCGTATAACGAACCTCAACATCTTTTCCGATTTTAGGCTACCTATAAGGAATTGAAACCAAAAATGGTCAGAACCCTGCAACAGCCCAAAAGAGGGATTTTAGGCTACCTATAAGGAATTGAAACTCAATTGTAACTGCAAGATGTTTAGCATCTTGAATGATTTTAGGCTACCTATAAGGAATTGAAACTGGACAAGTGGGACCGTGACGAAACCATAGACCGCGATTTTAGACTCCTATAAGGAGCTTGCAGG

>NZ_CP036259|2|2|153653-154010|PILER-CR
GATTTTAGGCTACCTATAAGGAATTGAAAC	GACTTACCCGGCTTATGAAGACACGATAACACAAGTC
GATTTTAGGCTACCTATAAGGAATTGAAAC	CTGCGTCACCCTCTTTTGCATCCGGCAGGGCCAG
GATTTTAGGCTACCTATAAGGAATTGAAAC	CCGGACTGCGTATAACGAACCTCAACATCTTTTCC
GATTTTAGGCTACCTATAAGGAATTGAAAC	CAAAAATGGTCAGAACCCTGCAACAGCCCAAAAGAGG
GATTTTAGGCTACCTATAAGGAATTGAAAC	TCAATTGTAACTGCAAGATGTTTAGCATCTTGAAT
GATTTTAGGCTACCTATAAGGAATTGAAAC

>NZ_CP036259|2|2|153653-154010|CRISPRCasFinder
GATTTTAGGCTACCTATAAGGAATTGAAAC	GACTTACCCGGCTTATGAAGACACGATAACACAAGTC
GATTTTAGGCTACCTATAAGGAATTGAAAC	CTGCGTCACCCTCTTTTGCATCCGGCAGGGCCAG
GATTTTAGGCTACCTATAAGGAATTGAAAC	CCGGACTGCGTATAACGAACCTCAACATCTTTTCC
GATTTTAGGCTACCTATAAGGAATTGAAAC	CAAAAATGGTCAGAACCCTGCAACAGCCCAAAAGAGG
GATTTTAGGCTACCTATAAGGAATTGAAAC	TCAATTGTAACTGCAAGATGTTTAGCATCTTGAAT
GATTTTAGGCTACCTATAAGGAATTGAAAC

>NZ_CP036259|2|2|153653-154075|CRT
GATTTTAGGCTACCTATAAGGAATTGAAAC	GACTTACCCGGCTTATGAAGACACGATAACACAAGTC
GATTTTAGGCTACCTATAAGGAATTGAAAC	CTGCGTCACCCTCTTTTGCATCCGGCAGGGCCAG
GATTTTAGGCTACCTATAAGGAATTGAAAC	CCGGACTGCGTATAACGAACCTCAACATCTTTTCC
GATTTTAGGCTACCTATAAGGAATTGAAAC	CAAAAATGGTCAGAACCCTGCAACAGCCCAAAAGAGG
GATTTTAGGCTACCTATAAGGAATTGAAAC	TCAATTGTAACTGCAAGATGTTTAGCATCTTGAAT
GATTTTAGGCTACCTATAAGGAATTGAAAC	TGGACAAGTGGGACCGTGACGAAACCATAGACCGC
GATTTTAGACTCCTATAAGGAGCTTGCAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144348623.1\|157220_158462_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224171
NZ_CP036259.1\|WP_144348616.1\|149192_150005_+\|hypothetical-protein	csm3gr7	pfam03787_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187857
NZ_CP036259.1\|WP_170233084.1\|150001_150643_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377130
NZ_CP036259.1\|WP_144348622.1\|155787_157224_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238896
NZ_CP036259.1\|WP_144348613.1\|145316_146900_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209
NZ_CP036259.1\|WP_144348618.1\|150639_151071_+\|hypothetical-protein	csx19	mkCas0132_csx19_CAS-III-D	unknown
NZ_CP036259.1\|WP_170233085.1\|162793_163114_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348627.1\|160529_161144_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|379721
NZ_CP036259.1\|WP_144352680.1\|144348_145293_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP036259.1\|WP_144348612.1\|141850_142261_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348615.1\|147562_149215_+\|hypothetical-protein	csx10gr5	cls000715_csx10gr5_CAS-III-D	gnl\|CDD\|131722
NZ_CP036259.1\|WP_144348620.1\|154298_155105_+\|MetQ/NlpA-family-lipoprotein	unknown	unknown	gnl\|CDD\|224381
NZ_CP036259.1\|WP_144348621.1\|155239_155791_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|319885
NZ_CP036259.1\|WP_144348624.1\|158473_159214_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|224067
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|366736
NZ_CP036259.1\|WP_144348614.1\|146856_147585_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	unknown
NZ_CP036259.1\|WP_144348619.1\|151057_153358_+\|hypothetical-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP036259.1\|WP_144348625.1\|159217_159856_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_170233083.1\|140957_141707_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP036259.1\|WP_144348626.1\|160311_160551_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215391

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144348623.1\|157220_158462_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224171	COG1251, NirB, NAD(P)H-nitrite reductase [Energy production and conversion].	1.28664e-79
NZ_CP036259.1\|WP_144348616.1\|149192_150005_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	9.03159e-12
NZ_CP036259.1\|WP_170233084.1\|150001_150643_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	3.03981e-10
NZ_CP036259.1\|WP_144348622.1\|155787_157224_+\|hypothetical-protein	gnl\|CDD\|238896	cd01915, CODH, Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to that of hybrid cluster protein (HCP) and a Ni-Fe-S center (C-cluster) where carbon monoxide oxidation occurs. Bifunctional CODH forms a heterotetramer with acetyl-CoA synthase (ACS) consisting of two CODH and two ACS subunits while monofunctional CODH forms a homodimer. Bifunctional CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP), while monofunctional CODH oxidizes carbon monoxide to carbon dioxide. CODH and ACS each have a metal cluster referred to as the C- and A-clusters, respectively.	4.52104e-44
NZ_CP036259.1\|WP_144348613.1\|145316_146900_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	1.14597e-05
NZ_CP036259.1\|WP_144348626.1\|160311_160551_+\|hypothetical-protein	gnl\|CDD\|215391	PLN02735, PLN02735, carbamoyl-phosphate synthase.	0.00224866
NZ_CP036259.1\|WP_144348627.1\|160529_161144_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|379721	pfam14907, NTP_transf_5, Uncharacterized nucleotidyltransferase. This family is likely to be an uncharacterized group of nucleotidyltransferases.	1.98554e-05
NZ_CP036259.1\|WP_144348621.1\|155239_155791_+\|4Fe-4S-binding-protein	gnl\|CDD\|319885	cd10563, CooF_like, CooF, iron-sulfur subunit of carbon monoxide dehydrogenase. This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.	2.36984e-62
NZ_CP036259.1\|WP_144348615.1\|147562_149215_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	4.14858e-12
NZ_CP036259.1\|WP_144348620.1\|154298_155105_+\|MetQ/NlpA-family-lipoprotein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.24881e-129
NZ_CP036259.1\|WP_144348624.1\|158473_159214_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|224067	COG1144, COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion].	1.65645e-07
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	4.88102e-11
NZ_CP036259.1\|WP_144348619.1\|151057_153358_+\|hypothetical-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	2.45654e-30
NZ_CP036259.1\|WP_170233083.1\|140957_141707_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	8.98276e-63

>NZ_CP036259.1|WP_144348619.1|151057_153358_+|hypothetical-protein
MAENRRGSRAGKADKLLPYDFVPFAETAYYPYQKPGTENRPDGRGGDLPGHDCRQNDKLSGFIEYTLTPYSDLALEIRQRLGGGYFMSGSQIRGRVRANLEILSASYPEFIDTTPLLYRDLTGKHSKDYRERINPDSEQRGIEYAVQAGFLVKEDDAFYIIPAPKIGEKYFLSIKEHRLLQMGMAQPGKCFRSLYCWEPEMLERFRQLQEQIDAFTKTIKMLRARLKSALQPIEGKIADKFRSNYGFQQRLKNILYDIRAKKNYSLPDELAGFKRKLLAELRPVGGQGNVEEFFQKLVDRWGLKAELYISYQQLRKNRDFRPYQQKVFLQKDENQGIIKISYQTGPEPAYLFNSTNASSKRSHYLVLAPGNSGSLPESYKVPAHVIAAYRRNLDKFRQTDKNTSVKEFYNIFEKYDEVCRQNNALAGLIVFFQQEQGEVRHVGRTPYFKIPYRHQLTTLLGRREPEKVDYAGALFGFVAEKTAAEPAERQAQAGLITAYKSRLRFTPVDIEPGDTQTPDLHKPPLQPFLLPTPRASACAMYLEQPAGGDLQTYEQLERPRLNGYKYYHIFPPTLKKGKPENWLNPGMLSNKPIIQRDSVKLLRGKIYFHNLTQAELGLLLLSLEPKQLLKTRQYGPQAEQYRCELEQAYDLIGGAKPYGYGKVKIEVRKLELEKSGCDFASLVLDTEEIIAAGTWGEYIDTFIAGMGGSKYFDTVHFRQYLQSKLELPDDNELITWDQLPTKIAEEKSSQVGYPKHWRLQRIGKKH
>NZ_CP036259.1|WP_144348618.1|150639_151071_+|hypothetical-protein
MNELAAFDITRLAMDDDYYFIAHTLDCVLLGRPGESDHRRLLAAIQNGTLLEAHFFNAAGEIFVTRSQDRLVQYEPLLHDRNGFAAGEVIAREYELEEKFRQQSGYHSLTVKEYIKYDEDHLAYVEKTVLFTLNKAGDAHGGK
>NZ_CP036259.1|WP_170233084.1|150001_150643_+|hypothetical-protein
MKKRDRANGGRTAGAEYYIPAASLKGVLRHEVRRLLGRMAHAAPAMAADQLPGKIEKHLADLFGSTDSTGKLTVHDIVVTGTPVTVARDSSQTDQPVYTKIDRLTGGSYVSALKRQQEIQGTAVISLELAVKPAADGYFHYIFPLVYVLRRLGAELVPLGGRTVAGLGQFKAPTVNIDCGGETWNIETGPDLSAGNRRQLEVWWEAFAGWCRQ
>NZ_CP036259.1|WP_144348616.1|149192_150005_+|hypothetical-protein
MWQRLIFEFAIRAVSPVRCGAVESEVVKDPNGKPVLLGNSLGGALRDYLRQGGVGKEAIEKIMGGEGEPGNRKGFKPSSIHISDGTVENYADEESDPLPRRQGTKINPVYGAAEQNQKYELEYLPAGTTVSFTIESDVWAGHEAKAGLQLRELEKVVATWANGFAGGAIVLGGRKSNGFGRFTLDSLQKRVFSLSSSQALDRFIFDGDESRPRRRCSGRRCRTIPCCPGEPLLSLCRASFPTACTRLFPWRIRMQAPGRWVPGADRLPVC
>NZ_CP036259.1|WP_144348615.1|147562_149215_+|hypothetical-protein
MECYLVIEIINQEPLKIGAGGSKASQREPAKDYIPGSTIRGAFIGRLKQQGLFASAWQDILLKAACHNAYPYRNGRLYLPAPQHLRLNKHDWRRQKALGDQTAQRAAVVQLAAGPAKDRKNTLPYRFLATYDGVSLSGLQVAKEYRLHHNTSRNPDREERDNLFRYEAIAAGQVFRTVFRCDQVLAPLLPAVFPEEETTIYLGGSKSSGYGLCRWKKIDDVRERYQDIKPLLGLPAQDRPQAPGQELWLTCLSDVLVRNRYGQPENDIPAAYIESISGEPVSPAEHFVHTGISEGYNATWQARYPKETTIKAGSVLHYTFDRELPGEQLQAIADQLEGRLVGERTQDGFGWLGVNLFYPEALQIAEQAAEKEPDSSGVQASWRQLAAAMEENEHVRNTWKLLAAGLDRAKKRWLQKIFLTDEQTQEPAADRFLLSPQLKRHHLQNMNQRLNRRDSSPDRPYMQDSRLCSIADCPFIAVLAYVTGAENAKLACYGQRYLQTASGQLFYAGESETAAPGSDKQRERKFILELLAMGLAIRIGRKTDVAKADF
>NZ_CP036259.1|WP_144348614.1|146856_147585_+|hypothetical-protein
MAETTYQIEVRLRSEAIFSSGEKESNQVQDRVLTDRYGLVYLHAKTLKGQLKRQAFWLLERYRSFDQARAQAFLKAMAVLFGMNGEEASLTGLSPDRRLLYQPGIMQLGHLALDERLRQYLIGLQDGGGEGLLGPLDLIEAQTHIRTGIQLEEGTAKEGRLTTYHTVKPGLTFYATVRFTADPEPYLDDLQRIICSLKRLGAGIHRGRGLVDSRLLLNGQSVPFTSGKGRETEVHHGMLSGY
>NZ_CP036259.1|WP_144348613.1|145316_146900_+|hypothetical-protein
MAVYAYIDVARKQEFIYKNNKLRDNLHNSFIIKAITEELDQPERPEGFCLSAYLEQAHPGQFTFVYSGGGNSIIRFASPDIAEVFVKNFSREVLCRHPDLELYISLVGDDEVPDRCPGNDKQLLEKLHRAADKQKNRRRSRFRRWTYGVEKIDETGQAVRREAKSSPETKAAREYLKEKFQALVSSQHFVVTTELKDYQKAEEGKSYIGVIALDGNKMGEMVAGAGCFAEIKELSTTIEAIYKEAVREALCTCAASFREQGRPICITPVLMAGDDICLIAEAEHAIAIAAAILQSIQTVSGRQKQNNALLGRVIAGGYLTACAGVAIARYHYPFFELVQAAEGLCSRAKEGLYHVPAGNGSFIDWEVLQGPVPVAQPYKQCRRPGPVKEIFHVKPLRVDRSEPAAPVTVQGICHYDAFIDFLRNVRKHVSTSLLAECRKHFYCGWEPYRLFFESHRDSGKLTELAERIFGSHAGVWEHAVLTTAQEGVPFSRTYILPDILEISPFIAVQEEEAYGGNNLSDRGAASQ
>NZ_CP036259.1|WP_144352680.1|144348_145293_+|hypothetical-protein
MSGREVFEKIYENYQDLNRKMVNELKLSSIQGGLTGHCREEMWLKFFRDIIPQKFSLSQGVIIIDSYGNASREVDIAVYDEQYTPYVFRYNTLKFIPIEAVAVVIECKSVKPGSTQLTKWVERIDALRTCQAGIARIATGYVMGLNNRIQTGTRPIKILACLQKGYGTKKLQQAFDFIITRKKDEAVHFQLNVANKRKSLGWWGQQLNCTGSADNDSQCLVLKEAAISNNDPDSWQGLNFTNESNEINNTLADLEIEDNPVLSLNLQLNQLLMLINNPMLFPHFAYARQFNKIAGIIKEKRRKQPHCEVEQNDA
>NZ_CP036259.1|WP_144348612.1|141850_142261_-|hypothetical-protein
MGHEKTTRLRPTVHTALAAGVRQQAGDAGDGLKSVLAQTFDQYVFTRVDHILSLAEADDDGYRQTVKDASNALDRLLALARRLKTQQPEMLGLVMDFESWAGLESGKAAEIAYRQGLRDSSQLRQEFMAYLQQQQD
>NZ_CP036259.1|WP_170233083.1|140957_141707_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MESEGSRRQNSGLTNRNHIKGRTRLGKIATQIKAQNYPKVCSVPLLLAVQADQPWYTLQDLVESAQKRPGQVKFGNVGMGSFPHILVEMINREAGINIAQVPFSGGGETVSALLGGHVQLILVNPVSIKEHVKNGTVRILAVTGERRIADPVFAQVLTFKEQGFDITVNNWHGIAIPKETPVAIKNKLAAGIKAIIDDPEFQANMERVGNQVEYLGPQESTDKWIADSQKLQKTLQESGIMEQIKAQKK
>NZ_CP036259.1|WP_144348620.1|154298_155105_+|MetQ/NlpA-family-lipoprotein
MKKLLALYLVIIAALFLGGCGSAEAPQQEAKILKVGVTSGPHAEILEQVKTVAERDGLKIEIVEFNDYVQPNTSLDQGEIDANAFQHQPFLDNHVKDRGYKLVSIAKTVILPMGIYSDKVKKLDELKDGSAVAIPNDPSNAGRALLLLDQAGLIKLKPGVGAAASVLDIVENPKNLKIKELEAALIPRAIADVDIAAINTSYALKAGLVPARDGLALENSSSPYTNVLAVREKDKDNPVFQKLIKAYHSEEVKKYLVEHFQGSILPGW
>NZ_CP036259.1|WP_144348621.1|155239_155791_+|4Fe-4S-binding-protein
MKRIWIDREKCLGCKSCELQCAIERDSVSKTLLGAVQETPKPMARVSVAGRTGRSFPLQCRQCQDAPCSRACPAGALQREPGTEVIFLDQAKCRGCWMCVMSCPFGVIVPSDTYKVAVKCDACIHREEPACVNACPTGALSQGDSADFQKILLKKRGRLALFALQNAEPGQVSLEFAGEDDKL
>NZ_CP036259.1|WP_144348622.1|155787_157224_+|hypothetical-protein
MKAVHKKSIDPAVNQVLVAAYRSQTPLIWDRAEALQPQCGFGRLAICCSDCQEGPCRTNPFAQETQHTICGQDNQALLTGKFLKKAADGAVALTQLAGQSGSGFGAEAIRQLVVTDDEMPVFTDGPGRLQTIGRCTNAALAELGRYQRETGGAWQPAVVGVNLGVLPADTVNIVFHGHVDRQVVAQFKAAAQAENIAVTLAGMCGNEFSGSLQLPVVTNYDSQEAPLLTGRVDLLVLGRQCVLPSLRQLAGQQGIAVLQATPAIDYQAAVHAARQASRRRPRAATAPSAVTEAWIGYTADNSAALLARVAEQYEQGQLQGIVYLGGCGLVANTQDEQPVKLAAALVAAGYLVVTAGCAGTALAKAGLCRPDWRHGDYPLQAVLPASVPPVLHLGSCHDAGELLGLAAVLPPRLPLAAVFPEINHNKVLATAVGFAAAGIPAWLGYDAIPGNAALPGSNIRPLPAVPELLQALAAAAGK
>NZ_CP036259.1|WP_144348623.1|157220_158462_+|FAD-dependent-oxidoreductase
MMNTGKAKPAWLIIGQGAAGAAAANELRRLDSEAAITVIAGEQAGFYSRIDLPDIISGKRRPEEAVLQSPAQFQAAGIRCLTGVQAVTIRPEDHYVELASGQRLPYDRLLLATGAQPVLPGLPGMTAAGVYTLWTLEQAAAIALAAAGARAAVVIGSGLIGLKTALALRQRGLQVTVIERMNRVLPQQLDETGAALLAAALRNRGIEVLTGVQVAAVATGGGKVAGIQAGSRLVPCELVLCAAGVRADTALARTAGLAIGAGIVVNEFLQTSQADIYAAGDAAEVIAVLAQQRCLSAGWPAAVEQGIIAARNLSGRSTEAYGGYLAKNSVEIAGVPLVSAGNVQGGDGAEVLIRRTGHGYKRLVIKNNRLRGFLLMGDIRQAGVLAGVMARTDAGGYGDAAGAAGSYVDLLAF
>NZ_CP036259.1|WP_144348624.1|158473_159214_+|4Fe-4S-dicluster-domain-containing-protein
MRIDKDKCAGCGQCTEFCTLGRIAVCRRDPRTGKLYYEINEDECVDCGVCLRAGVCSAGALYMPAYAWPRTVRSAFSDPTVEHRDTKVAGRGTEEIKTNEITGRIKRGFVGISCEMGRPSVGARFYDIEKVAMALARLGVEFEPNNPCTRLMADPQTGRYKAEVLNEKVLSAIIEMIIPLAQLPAVLTAIRGAAAGVDCVFCVDLITVLEPGNAIPTLPLLQSLQWPVSPNGKMNTGLGRPLAKEG
>NZ_CP036259.1|WP_144348625.1|159217_159856_+|hypothetical-protein
MSHTLHRQGTPANLDNDFPMHALPARGFNHEGALPKLKQFLAIAHRHNPVNLGDVKLGNKYVTAYDELYEQLTTSSTHAVLADKDDLTALLAEVKAADLGMSLTISGLFARLFACCDQAGIQPHAVEHSLGVLGKTEQMPEAEIAQITTMCGHAMVAQGLVRRLIGKVKKGEMTPAEAGIELAKPCRCGIFNPARAAMLIDEYCALFTVTVR
>NZ_CP036259.1|WP_144348626.1|160311_160551_+|hypothetical-protein
MIKKPISLDIAIQETRKRFNQIPPSLRPKKNKRPAGRRSEEEATALARSVYYSVKKAEEEGYIQKNSGGYRMLWTAVQK
>NZ_CP036259.1|WP_144348627.1|160529_161144_+|nucleotidyltransferase-family-protein
MDSRAKIVLAAQIEDPLKRQMRVAAIIATELEQKGTQAVLVGGSAVEFYTVANYLTRDIDFVVTKPDHIGEVMTGLGFKNDSGTWYLPEYQQVVVEFPKGPLDGSWERVQKVIGPDGTSVNIISVEDILIDRASGIRFWNDPDEWVKYIMVGNYDRIDWEYLEQRARDLQCDAVIQTSKEWAKEKREIFRQDSGDLQAEAEKKS
>NZ_CP036259.1|WP_144348628.1|161583_162348_+|phosphotransferase
MRINDLVNRIGFGSKAVVFRHENKAIKLFEPGYLETNAYFEVKLQQLALNASLPVPMVYGVTVSNDRVMIEMEYIKGKTLGDRMLADMRHIADFISRSVELQIEVHKVKAKDFPSQKDKLMRDIEAAKLLNKNQKLTLQNMLHSFISEDLLCHGDFHAFNIIQSNQGLVIIDWVDATCGCIAADVCRSFLLYLLTNKEVANLYLQHYCERSTSVTKEEVLKWLPIIAGARLSENNLHDAVNVLLHIVENGRLPS
>NZ_CP036259.1|WP_170233085.1|162793_163114_-|hypothetical-protein
MLKGMLHAAFDQYVFTRVDNILNLAGTNDPGYTKTGGEVSAALDRVLALARALKAQHPELLDLVMDFEALTALESGQAAEIAYRQGLRDSSQIRQEFMTFLQQQYD

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Crispr_ID: NZ_CP036259_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_3

164060-164550

TypeIII

Consensus_repeat	Method
GTTTTTAGGCTACCTATAAGGATTTGAAAT	PILER-CR
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CRISPRCasFinder
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CRT

7 spacers

PD-DExK,cas10,csm3gr7,csx10gr5,cas6,cas8b1,cas7b

The CRISPR arrays of NZ_CP036259_3

>merge|NZ_CP036259|3|164060-164550|PILER-CR,CRISPRCasFinder,CRT
GTTTTTAGGCTACCTATAAGGATTTGAAATCAGAATAAAGCTATCGGTCAGGATGCACTGCTGGCGTTTTTAGGCTACCTATAAGGATTTGAAATCCGCTCATGAGAAAATGGCCAATGCCGCGGAGGCCGTTTTTAGGCTACCTATAAGGATTTGAAATGCTTCTGCTACTGCGACTGCCAGCATTTCAGCATTCGTTTTTAGGCTACCTATAAGGATTTGAAATGGATATCGCCTGTATCTGCTATAGCCAACGTCAGGAGTTTTTAGGCTACCTATAAGGATTTGAAATTAAATATGAATAATCGTAGACGCAATCTATATCGTGTTTTTAGGCTACCTATAAGGATTTGAAATCTGTAACTTGCGGACGTACTGTAAATTCCACCTTCTGTTTTTAGGCTACCTATAAGGATTTGAAATGCAGCCAGCTCGCGCATGAATTCCCGTTGAGTTCGACCGTTTTTAGGCTACCTATAAGGAGTGGAACT

>NZ_CP036259|3|3|164060-164482|PILER-CR
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CAGAATAAAGCTATCGGTCAGGATGCACTGCTGGC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CCGCTCATGAGAAAATGGCCAATGCCGCGGAGGCC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GCTTCTGCTACTGCGACTGCCAGCATTTCAGCATTC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GGATATCGCCTGTATCTGCTATAGCCAACGTCAGGA
GTTTTTAGGCTACCTATAAGGATTTGAAAT	TAAATATGAATAATCGTAGACGCAATCTATATCGT
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CTGTAACTTGCGGACGTACTGTAAATTCCACCTTCT
GTTTTTAGGCTACCTATAAGGATTTGAAAT

>NZ_CP036259|3|3|164060-164550|CRISPRCasFinder
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CAGAATAAAGCTATCGGTCAGGATGCACTGCTGGC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CCGCTCATGAGAAAATGGCCAATGCCGCGGAGGCC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GCTTCTGCTACTGCGACTGCCAGCATTTCAGCATTC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GGATATCGCCTGTATCTGCTATAGCCAACGTCAGGA
GTTTTTAGGCTACCTATAAGGATTTGAAAT	TAAATATGAATAATCGTAGACGCAATCTATATCGT
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CTGTAACTTGCGGACGTACTGTAAATTCCACCTTCT
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GCAGCCAGCTCGCGCATGAATTCCCGTTGAGTTCGACC
GTTTTTAGGCTACCTATAAGGAGTGGAACT

>NZ_CP036259|3|3|164060-164550|CRT
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CAGAATAAAGCTATCGGTCAGGATGCACTGCTGGC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CCGCTCATGAGAAAATGGCCAATGCCGCGGAGGCC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GCTTCTGCTACTGCGACTGCCAGCATTTCAGCATTC
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GGATATCGCCTGTATCTGCTATAGCCAACGTCAGGA
GTTTTTAGGCTACCTATAAGGATTTGAAAT	TAAATATGAATAATCGTAGACGCAATCTATATCGT
GTTTTTAGGCTACCTATAAGGATTTGAAAT	CTGTAACTTGCGGACGTACTGTAAATTCCACCTTCT
GTTTTTAGGCTACCTATAAGGATTTGAAAT	GCAGCCAGCTCGCGCATGAATTCCCGTTGAGTTCGACC
GTTTTTAGGCTACCTATAAGGAGTGGAACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144348626.1\|160311_160551_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215391
NZ_CP036259.1\|WP_144348625.1\|159217_159856_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	gnl\|CDD\|187857
NZ_CP036259.1\|WP_144352681.1\|165195_166188_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP036259.1\|WP_170233085.1\|162793_163114_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348627.1\|160529_161144_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|379721
NZ_CP036259.1\|WP_144348634.1\|171495_171903_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348623.1\|157220_158462_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224171
NZ_CP036259.1\|WP_144348621.1\|155239_155791_+\|4Fe-4S-binding-protein	unknown	unknown	gnl\|CDD\|319885
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP036259.1\|WP_144348620.1\|154298_155105_+\|MetQ/NlpA-family-lipoprotein	unknown	unknown	gnl\|CDD\|224381
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	csx10gr5	cls000715_csx10gr5_CAS-III-D	gnl\|CDD\|131722
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|377130
NZ_CP036259.1\|WP_144348624.1\|158473_159214_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|224067
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|366736
NZ_CP036259.1\|WP_144348622.1\|155787_157224_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238896
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP036259.1\|WP_144348637.1\|176856_178899_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144348626.1\|160311_160551_+\|hypothetical-protein	gnl\|CDD\|215391	PLN02735, PLN02735, carbamoyl-phosphate synthase.	0.00224866
NZ_CP036259.1\|WP_144348624.1\|158473_159214_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|224067	COG1144, COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion].	1.65645e-07
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	1.97018e-06
NZ_CP036259.1\|WP_144348627.1\|160529_161144_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|379721	pfam14907, NTP_transf_5, Uncharacterized nucleotidyltransferase. This family is likely to be an uncharacterized group of nucleotidyltransferases.	1.98554e-05
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	1.31869e-11
NZ_CP036259.1\|WP_144348622.1\|155787_157224_+\|hypothetical-protein	gnl\|CDD\|238896	cd01915, CODH, Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to that of hybrid cluster protein (HCP) and a Ni-Fe-S center (C-cluster) where carbon monoxide oxidation occurs. Bifunctional CODH forms a heterotetramer with acetyl-CoA synthase (ACS) consisting of two CODH and two ACS subunits while monofunctional CODH forms a homodimer. Bifunctional CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP), while monofunctional CODH oxidizes carbon monoxide to carbon dioxide. CODH and ACS each have a metal cluster referred to as the C- and A-clusters, respectively.	4.52104e-44
NZ_CP036259.1\|WP_144348623.1\|157220_158462_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224171	COG1251, NirB, NAD(P)H-nitrite reductase [Energy production and conversion].	1.28664e-79
NZ_CP036259.1\|WP_144348621.1\|155239_155791_+\|4Fe-4S-binding-protein	gnl\|CDD\|319885	cd10563, CooF_like, CooF, iron-sulfur subunit of carbon monoxide dehydrogenase. This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.	2.36984e-62
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.72446e-34
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.52316e-33
NZ_CP036259.1\|WP_144348620.1\|154298_155105_+\|MetQ/NlpA-family-lipoprotein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.24881e-129
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	8.69091e-10
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	0.00603178
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	4.88102e-11
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	9.67947e-72

>NZ_CP036259.1|WP_170233085.1|162793_163114_-|hypothetical-protein
MLKGMLHAAFDQYVFTRVDNILNLAGTNDPGYTKTGGEVSAALDRVLALARALKAQHPELLDLVMDFEALTALESGQAAEIAYRQGLRDSSQIRQEFMTFLQQQYD
>NZ_CP036259.1|WP_144348628.1|161583_162348_+|phosphotransferase
MRINDLVNRIGFGSKAVVFRHENKAIKLFEPGYLETNAYFEVKLQQLALNASLPVPMVYGVTVSNDRVMIEMEYIKGKTLGDRMLADMRHIADFISRSVELQIEVHKVKAKDFPSQKDKLMRDIEAAKLLNKNQKLTLQNMLHSFISEDLLCHGDFHAFNIIQSNQGLVIIDWVDATCGCIAADVCRSFLLYLLTNKEVANLYLQHYCERSTSVTKEEVLKWLPIIAGARLSENNLHDAVNVLLHIVENGRLPS
>NZ_CP036259.1|WP_144348627.1|160529_161144_+|nucleotidyltransferase-family-protein
MDSRAKIVLAAQIEDPLKRQMRVAAIIATELEQKGTQAVLVGGSAVEFYTVANYLTRDIDFVVTKPDHIGEVMTGLGFKNDSGTWYLPEYQQVVVEFPKGPLDGSWERVQKVIGPDGTSVNIISVEDILIDRASGIRFWNDPDEWVKYIMVGNYDRIDWEYLEQRARDLQCDAVIQTSKEWAKEKREIFRQDSGDLQAEAEKKS
>NZ_CP036259.1|WP_144348626.1|160311_160551_+|hypothetical-protein
MIKKPISLDIAIQETRKRFNQIPPSLRPKKNKRPAGRRSEEEATALARSVYYSVKKAEEEGYIQKNSGGYRMLWTAVQK
>NZ_CP036259.1|WP_144348625.1|159217_159856_+|hypothetical-protein
MSHTLHRQGTPANLDNDFPMHALPARGFNHEGALPKLKQFLAIAHRHNPVNLGDVKLGNKYVTAYDELYEQLTTSSTHAVLADKDDLTALLAEVKAADLGMSLTISGLFARLFACCDQAGIQPHAVEHSLGVLGKTEQMPEAEIAQITTMCGHAMVAQGLVRRLIGKVKKGEMTPAEAGIELAKPCRCGIFNPARAAMLIDEYCALFTVTVR
>NZ_CP036259.1|WP_144348624.1|158473_159214_+|4Fe-4S-dicluster-domain-containing-protein
MRIDKDKCAGCGQCTEFCTLGRIAVCRRDPRTGKLYYEINEDECVDCGVCLRAGVCSAGALYMPAYAWPRTVRSAFSDPTVEHRDTKVAGRGTEEIKTNEITGRIKRGFVGISCEMGRPSVGARFYDIEKVAMALARLGVEFEPNNPCTRLMADPQTGRYKAEVLNEKVLSAIIEMIIPLAQLPAVLTAIRGAAAGVDCVFCVDLITVLEPGNAIPTLPLLQSLQWPVSPNGKMNTGLGRPLAKEG
>NZ_CP036259.1|WP_144348623.1|157220_158462_+|FAD-dependent-oxidoreductase
MMNTGKAKPAWLIIGQGAAGAAAANELRRLDSEAAITVIAGEQAGFYSRIDLPDIISGKRRPEEAVLQSPAQFQAAGIRCLTGVQAVTIRPEDHYVELASGQRLPYDRLLLATGAQPVLPGLPGMTAAGVYTLWTLEQAAAIALAAAGARAAVVIGSGLIGLKTALALRQRGLQVTVIERMNRVLPQQLDETGAALLAAALRNRGIEVLTGVQVAAVATGGGKVAGIQAGSRLVPCELVLCAAGVRADTALARTAGLAIGAGIVVNEFLQTSQADIYAAGDAAEVIAVLAQQRCLSAGWPAAVEQGIIAARNLSGRSTEAYGGYLAKNSVEIAGVPLVSAGNVQGGDGAEVLIRRTGHGYKRLVIKNNRLRGFLLMGDIRQAGVLAGVMARTDAGGYGDAAGAAGSYVDLLAF
>NZ_CP036259.1|WP_144348622.1|155787_157224_+|hypothetical-protein
MKAVHKKSIDPAVNQVLVAAYRSQTPLIWDRAEALQPQCGFGRLAICCSDCQEGPCRTNPFAQETQHTICGQDNQALLTGKFLKKAADGAVALTQLAGQSGSGFGAEAIRQLVVTDDEMPVFTDGPGRLQTIGRCTNAALAELGRYQRETGGAWQPAVVGVNLGVLPADTVNIVFHGHVDRQVVAQFKAAAQAENIAVTLAGMCGNEFSGSLQLPVVTNYDSQEAPLLTGRVDLLVLGRQCVLPSLRQLAGQQGIAVLQATPAIDYQAAVHAARQASRRRPRAATAPSAVTEAWIGYTADNSAALLARVAEQYEQGQLQGIVYLGGCGLVANTQDEQPVKLAAALVAAGYLVVTAGCAGTALAKAGLCRPDWRHGDYPLQAVLPASVPPVLHLGSCHDAGELLGLAAVLPPRLPLAAVFPEINHNKVLATAVGFAAAGIPAWLGYDAIPGNAALPGSNIRPLPAVPELLQALAAAAGK
>NZ_CP036259.1|WP_144348621.1|155239_155791_+|4Fe-4S-binding-protein
MKRIWIDREKCLGCKSCELQCAIERDSVSKTLLGAVQETPKPMARVSVAGRTGRSFPLQCRQCQDAPCSRACPAGALQREPGTEVIFLDQAKCRGCWMCVMSCPFGVIVPSDTYKVAVKCDACIHREEPACVNACPTGALSQGDSADFQKILLKKRGRLALFALQNAEPGQVSLEFAGEDDKL
>NZ_CP036259.1|WP_144348620.1|154298_155105_+|MetQ/NlpA-family-lipoprotein
MKKLLALYLVIIAALFLGGCGSAEAPQQEAKILKVGVTSGPHAEILEQVKTVAERDGLKIEIVEFNDYVQPNTSLDQGEIDANAFQHQPFLDNHVKDRGYKLVSIAKTVILPMGIYSDKVKKLDELKDGSAVAIPNDPSNAGRALLLLDQAGLIKLKPGVGAAASVLDIVENPKNLKIKELEAALIPRAIADVDIAAINTSYALKAGLVPARDGLALENSSSPYTNVLAVREKDKDNPVFQKLIKAYHSEEVKKYLVEHFQGSILPGW
>NZ_CP036259.1|WP_144352681.1|165195_166188_+|hypothetical-protein
MADNKETKQEPDGSEVFEKIYENYQDLNRKMVNELNLSSIHGGLTGHCREEMWLNFFRGIIPQKFSLAQGVIIIDAYGNASREVDIAVYDEQYTPYVFRYNMLKFIPIEAVAVVIECKSVDPGNKQLTEWAKSIDALRTCRAGIARMATGYFAGLNNPTQTGTRPIKILACLKEVVRDGTWEACWQELQQSFDFIIAKKKDKDKYFELVVANKQKNLGWWGQQLNGISSASNDLQGLALERDIPESDPDSYKGLIFAADSSTLVKNTLADLEIEGNPILSLNLQLNQLLMLINNPMLFPHFAYAQQFNDIANLIKEKRQKQPHCEAEQNA
>NZ_CP036259.1|WP_144348630.1|166204_167758_+|hypothetical-protein
MAVYAYIDVARKQEFIYKNNKLRDNLHNSFLIKAITEELDRPDRPEDFCLSAYLEQAHPGQFAFVYSGGGNSIIRLDTPDIGKEFVRKFSSAVLRRHPDLELYISLVGDDGTDKQLIENLHKAADEQKNRRRSRCRRWTYGVEKIDETGQAVRKESKNSSETKAAREYLKEKFQALVPPAHFFITTELKDYKKDEEGKSYIGVIAIDGNKMGEMVAGASGFAEIKELSNTIEAIYREAVRDALFSCFAPDRERTRRICITPVLMAGDDICLIVEAEQAIEIAAAILRSIQMVSGRKKQNNSLLGRLIAGDYLTACAGVAIARYNYPFFELVQAAEGLCSRAKEALYKVPANKGSFIDWEVLPGPVPVARPQYARSGPVKEIFHVKPLRVDRTVPAEPVTAQGIYHYDAFIDFLRCVRQQVSTSSLAECRKHFYAGWEQYRLFLEFHKDSGKLTELAERIFGAKAGVWEYAALTTKQQDVPFSRTYILNDILETSPFIALQEEEEYGGTDLSNRGAAL
>NZ_CP036259.1|WP_144348631.1|167717_168446_+|hypothetical-protein
MAEPTYQIEVRLCSEAIFSSGEKECNLVQDRVLTDKYGLVYLHAKTFKGQLKRQAFWLLERYRSFDQALAQALLANMAVIFGMNQEETSLARLSPDRRLLYQPGIMHLGHLELDERIRQHLIGLQAGGEAALLSPFDLIEAQTNTRTGIQIADGAAKDGRLTTYHTVKQGMVFYSTVRFTADPEPYLADLQRIVCSLDRLGAGIHRGRGLVKAQFLINGQRIPLTSSKIQETGAPHGMLSGY
>NZ_CP036259.1|WP_144348632.1|168423_170076_+|hypothetical-protein
MECYLVIEIINQEPLKIGAGGSKASQREPAKDYIPGSTIRGAWIGRLKQQGLFASAWQDILLKAACHNAYPYRNGRLYLPAPQHLRLNKHDWRQQKVVCAHALQSAAAVVPLAAGQTKERKNTLPYRFLTTYDGKTLSGLHVAKEYRLHHNTGRNRDREERDNLFRYEAIAAGQVFRTVLRCDPALVPLLMAVFPEEETPVYLGGSKSSGYGLCRWKKIGNVLACYQEAKVLLGLPDQDRRQAPGRDLWITCLSDVLVRNCYGQPVNAIPEEYIERISGEPVSLEKRFIHTGISEGYNATWQARYPKETTLKAGSVLHYTFAGELQGEQLQAIADRLESRLVGERAQDGFGWLGVNLPYPDVLQIGERPAEQEPERMFESNWRELAAAIEGDEHVRDTWELLAAGLAGAKNRWLQKIFLMDELAQGPESERFILAAQLKKHHLQNMKRWLNCRDLSPDRPYTRDNRQCSIAGCHFVAVLDYLNGAENTQLACYAQRYLQTAPGRLFYAGEKEQAERTEVTGREKRFISQLLEMGLKIRIGRKADVAKTDL
>NZ_CP036259.1|WP_144348633.1|170053_171499_+|hypothetical-protein
MWQRLIYEFAIRAVSPVRCGANETEVVKTPDGKPVILGNSLGGALRAYLQQGGVRTEDIEKAMGGEVESAEEKKKFLPSRIYISDGMIENYSDGEKQGLPRQEGTAVNPVYGAAEPHQKYMLEYLPAGTTVNFKIESDVWAGAGKEHNDALQPAELEKLVATWANGFAGGQLLLGGQKSNGFGRFTLDSLQARVVFLDNSQALDRYIFGSREKPAMEDVPWQAMPQYPLVPQCAVTFTLQGVFPYGVYQAFPVTADAGAQAAGARREPLTGLLKKRDNKDNGKHKEGQEQAYYIPAASLKGVLRHEVLRLLGRMMSDTADQGCGKNLTDLFGGTGSPGKLTVHDIVVTGTPVAVNRDSRQTDLPIYIKIDRLTGSSYDSALKRQQEIQGTAVISLELAVKPADDGYLNYIFPLVYVLRRLGAGLIPLGGRTVAGLGQFLAPTVNIGAGEETWQIETGPELSTGNRRQLEMWWESFAGWCRQ
>NZ_CP036259.1|WP_144348634.1|171495_171903_+|hypothetical-protein
MNELSAFDIAKLDMHDDYYFIAHTLDCVLLGRAKEPAHGRLLAAIQGGTLLEAHFFDTTREIFVTRSQDRLVQYEPLLHNQNAFAKDEIVSREYELEEKFRNQSGYYSLTVKEYINYDEDHLAYVEKTVLYCLGR
>NZ_CP036259.1|WP_170233086.1|171919_174031_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MENERPRNMDNRLNQLKAYKEVILPYDFVPFSATTYYPYQKTRTGSKGNRQAGNLLPGHDRKENNNVSGFVQYTLQPCSDLVLETREKLKGGYFVSGSQFRGRIRANLEILSASYPQFVNTTPLLYRDLAGDLSKLYREKLGLVKNKGIEHVVQAGFLIKNENDFYVIPAPKIGDKNFLSIKEHRLIQMQIDKSAKQFSPLFCWDSNKISTFARIQKQIDDMNEKVLQRRQLQFEMKKKYFGLVPNDSFIPYQQRLFAQVNENHTVDNLSFAKLPEEKCHLAYLFNSTNASSKRSHYLVLEPGQNDRNRNHSNQYKVSDALIAAYQQNLKKNRAFDEETEIGIMKKQFYDIFGSYDNILMRHSGSVGLVVFFQLDGEKLKNIGRTPYFKIPCRHQLTSLLGIRKQEKVDCASALFGFTAEKEPADQRKDVSIDTIPSYKSRLRFTSLDIELADAQTLELQKQPFLLPTPYASACAMYLEQPEGKSLQTYEQPARPQLNGYKYYHILPKQLKVQNQADWPNPNMLSYKPVIKYGSVRLLRGKIYFHNLTKAELGVLLLSLEPKQLLKTRQYGPQAEQFRSELEQAYDLVGGAKPYGYGKVKIEVRQLALEKSGRDFTSLVVDTEEIIADATWGEYIDAFIADMGGGNYFNTVHFRQYLQSKLELQDASELITWDQLPKKIAAETNSSQGGYPKHWRLKRTGKKS
>NZ_CP036259.1|WP_144348636.1|175237_175972_+|CRISPR-associated-endoribonuclease-Cas6
MHLDIHFKPAGGRLVLPISYNYLLQGALYHSLHKELAAFLHEKGYTDGKRSFKLFSFSLLQGVYQLDRVKKNIAFDGEIKLTISSPMQDFCHSLVNILLATGNMRLGTQATEIEKINVRQLKVTGDQAVVKTLSPAVLYSTLLRPDGRKYTVYFQPGEADYGRLFSENLQKKYRAFWGTDAPAGNVTAKALGLPRLKVVNYKDIIIKGYAGKLLVTGPQELLQLAVDGGIGSKNSQGFGCVELQ
>NZ_CP036259.1|WP_144348637.1|176856_178899_+|hypothetical-protein
MLAESIIRIGRPIKDGGMPCREKIRLLTDVSSENCKNFFRHVFLIELAGGDSCLQQLELGDMALENNKETFTVDSQRNVTFPIFYPNGGNPLHAQGIYPLPCYLLYDPHLKALGEKEQFKKEFLSPRLNNTLQYRDMTLSEKELLADQVAVLLAAQATEFISEDKQLGILMIYDARLNVFQEKQDWMGEDETLMWINESRLQPGRQLYLDGEEVLQCINQAKFYEAAELGSEKNAVSTFSNQPAAEVVSIYNKAWLWLSPTWDMPRSIYWQDDEWTKGIKVDAESYAAYFYGVQFLKEIQVPVASAVLKEMFAPVTSVEAKKNMKATSFESIYGIPLVLPLTDGGSQQLFANYRRMLKKDSEKQSNSDLHLKVLAGIDRVVPEIGDEHRLTILYYSGDLSRGNMHIRAVIEDIVPSVAGKIEQILHDLKVSETGKIQLAFGVAEQAVYKTQTLPALLANAFGPGYVWETLQAALHKEPLRLERLRLTTARRLNELANKEDTWQMVQELIFYYSFLYFLHQYEQKILQKQGGVMILSDWDEFKALYSQGRLDLCHLASVEQLGFTAGLLLRQFHNSYYQKTGKDFVKQRVMKFGSKLTPAMIWKNGLLRCEELAQQWNMKLGANFRPVLAQALLGFLAKQDQLVPEKDSFMTAFWSGYLLYKADKKNDKTEEDGGNDNEQQ
>NZ_CP036259.1|WP_144348638.1|178885_179836_+|CRISPR-associated-protein
MNSSEILFIKAVKDGIPNRDPLNDSDARRLFPEEDGRISLSDVSIKRDVRDFVIAYENNGGATQKNHIFVQEKINDKGKLLGRGSLAELIARSVGAEKQAKDDMKSVLKDHCFDVRTFGIVYSVKPKFHLTGPVQFGWAHSLHPVDTQYVQGTVVMPSTDSNDEGEGKTQGTIWTSYTLPFAVFAMPAVINAKAAEHSGMTTADQELLLRALWQGTQHRQARGRGQQQPLILVHIEYNDPFYRIGYPEDLIAMAPDAAAWKAAGKQPSSLQDVVFDLTRLLAVVAEKREKIARCRIWLHPGVKISGTVEPFVQPLW

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Crispr_ID: NZ_CP036259_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_5

176140-176497

TypeIII

Consensus_repeat	Method
GTTTTTAGGCTACCTATAAGGATTTGAAAC	PILER-CR
GATTCTAGGCTACCTATTAGGATTTGAAAC	CRISPRCasFinder
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CRT

5 spacers

cas6,csm3gr7,csx10gr5,cas10,PD-DExK,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

The CRISPR arrays of NZ_CP036259_5

>merge|NZ_CP036259|5|176140-176497|PILER-CR,CRISPRCasFinder,CRT
GTTTTTAGGCTACCTATAAGGATTTGAAACTGAGTAATTTCTTATGAGCGGCGCTGCCAACGAACTCGTTTTTAGGCTACCTATAAGGATTTGAAACCCCTTAGTCCGGGCCTGACAGTTATCACCGGTCCGGTTTTTAGGCTACCTATAAGGATTTGAAACCCGTCTGATTCTATAGCAAGAAACTGAACATCACCGTTTTTAGGCTACCTATAAGGATTTGAAACATAGCGACCAGGGAAGCAACCAGCGCGTTCATGGCGTTTTTAGGCTACCTATAAGGATTTGAAACCGACATACCACAGTCTTCTCTCCTCGTCCATGCTACGTTTTTAGGCTACCTATAAGGAATTTGAGG

>NZ_CP036259|5|5|176140-176431|PILER-CR
GTTTTTAGGCTACCTATAAGGATTTGAAAC	TGAGTAATTTCTTATGAGCGGCGCTGCCAACGAACTC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CCCTTAGTCCGGGCCTGACAGTTATCACCGGTCCG
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CCGTCTGATTCTATAGCAAGAAACTGAACATCACC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	ATAGCGACCAGGGAAGCAACCAGCGCGTTCATGGC
GTTTTTAGGCTACCTATAAGGATTTGAAAC

>NZ_CP036259|5|5|176140-176497|CRISPRCasFinder
GTTTTTAGGCTACCTATAAGGATTTGAAAC	TGAGTAATTTCTTATGAGCGGCGCTGCCAACGAACTC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CCCTTAGTCCGGGCCTGACAGTTATCACCGGTCCG
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CCGTCTGATTCTATAGCAAGAAACTGAACATCACC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	ATAGCGACCAGGGAAGCAACCAGCGCGTTCATGGC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CGACATACCACAGTCTTCTCTCCTCGTCCATGCTAC
GTTTTTAGGCTACCTATAAGGAATTTGAGG

>NZ_CP036259|5|5|176140-176497|CRT
GTTTTTAGGCTACCTATAAGGATTTGAAAC	TGAGTAATTTCTTATGAGCGGCGCTGCCAACGAACTC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CCCTTAGTCCGGGCCTGACAGTTATCACCGGTCCG
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CCGTCTGATTCTATAGCAAGAAACTGAACATCACC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	ATAGCGACCAGGGAAGCAACCAGCGCGTTCATGGC
GTTTTTAGGCTACCTATAAGGATTTGAAAC	CGACATACCACAGTCTTCTCTCCTCGTCCATGCTAC
GTTTTTAGGCTACCTATAAGGAATTTGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144352681.1\|165195_166188_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP036259.1\|WP_170233087.1\|185433_185595_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209
NZ_CP036259.1\|WP_144348645.1\|186417_187458_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320692
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	gnl\|CDD\|187857
NZ_CP036259.1\|WP_170233085.1\|162793_163114_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348634.1\|171495_171903_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|377130
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	csx10gr5	cls000715_csx10gr5_CAS-III-D	gnl\|CDD\|131722
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|366736
NZ_CP036259.1\|WP_144348644.1\|185677_186073_-\|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain	unknown	unknown	gnl\|CDD\|377356
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP036259.1\|WP_144348637.1\|176856_178899_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP036259.1\|WP_144352681.1\|165195_166188_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	6.7e-27	88.3	0.0
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	7.4e-61	201.1	0.0
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	1.9e-20	68.7	0.0
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	1.3e-38	128.0	0.0
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	1.5e-42	140.5	0.0
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	3.8e-141	464.6	6.1
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	3.3e-52	173.0	2.5
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	1.5e-51	169.5	0.3
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	csx10gr5	cls000715_csx10gr5_CAS-III-D	2.8e-16	54.3	0.2
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	1.4e-28	94.5	0.0
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	2e-60	199.3	0.0
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	2e-25	84.5	0.0
NZ_CP036259.1\|WP_144348637.1\|176856_178899_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	8.8e-286	944.4	0.5
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.2e-30	100.3	0.9

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.54992e-22
NZ_CP036259.1\|WP_144348645.1\|186417_187458_-\|M48-family-metalloprotease	gnl\|CDD\|320692	cd07333, M48C_bepA_like, Peptidase M48C Ste24p bepA-like, integral membrane protein. This family contains peptidase M48C Ste24p protease bepA (formerly yfgC)-like proteins considered to be putative metallopeptidases, containing a zinc-binding motif, HEXXH, and a COOH-terminal ER retrieval signal (KKXX). They proteolytically remove the C-terminal three residues of farnesylated proteins. They are integral membrane proteins associated with the endoplasmic reticulum and golgi, binding one zinc ion per subunit. In eukaryotes, Ste24p is required for the first NH2-terminal proteolytic processing event within the a-factor precursor, which takes place after COOH-terminal CAAX modification (C is cysteine; A is usually aliphatic; X is one of several amino acids) is complete. Mutation studies have shown that the HEXXH protease motif, which is extracellular but adjacent to a transmembrane domain and therefore close to the membrane surface, is critical for Ste24p activity. Several members of this family also contain tetratricopeptide (TPR) repeat motifs, which are involved in a variety of functions including protein-protein interactions. BepA has been shown to possess protease activity and is responsible for the degradation of incorrectly folded LptD, an essential outer-membrane protein (OMP) involved in OM transport and assembly of lipopolysaccharide. Overexpression of the bepA protease causes abnormal biofilm architecture.	4.98086e-62
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	1.97018e-06
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	1.31869e-11
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.72446e-34
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.94311e-35
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.52316e-33
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.0003e-72
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	8.69091e-10
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	0.00603178
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	4.88102e-11
NZ_CP036259.1\|WP_144348644.1\|185677_186073_-\|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain	gnl\|CDD\|377356	pfam04432, FrhB_FdhB_C, Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminus. Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits,. The N-terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2) is also a member of this family. This region is often found in association with the 4Fe-4S binding domain, fer4 (pfam00037).	0.00265623
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	9.67947e-72
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.86885e-175
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.47909e-32

>NZ_CP036259.1|WP_144348636.1|175237_175972_+|CRISPR-associated-endoribonuclease-Cas6
MHLDIHFKPAGGRLVLPISYNYLLQGALYHSLHKELAAFLHEKGYTDGKRSFKLFSFSLLQGVYQLDRVKKNIAFDGEIKLTISSPMQDFCHSLVNILLATGNMRLGTQATEIEKINVRQLKVTGDQAVVKTLSPAVLYSTLLRPDGRKYTVYFQPGEADYGRLFSENLQKKYRAFWGTDAPAGNVTAKALGLPRLKVVNYKDIIIKGYAGKLLVTGPQELLQLAVDGGIGSKNSQGFGCVELQ
>NZ_CP036259.1|WP_170233086.1|171919_174031_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MENERPRNMDNRLNQLKAYKEVILPYDFVPFSATTYYPYQKTRTGSKGNRQAGNLLPGHDRKENNNVSGFVQYTLQPCSDLVLETREKLKGGYFVSGSQFRGRIRANLEILSASYPQFVNTTPLLYRDLAGDLSKLYREKLGLVKNKGIEHVVQAGFLIKNENDFYVIPAPKIGDKNFLSIKEHRLIQMQIDKSAKQFSPLFCWDSNKISTFARIQKQIDDMNEKVLQRRQLQFEMKKKYFGLVPNDSFIPYQQRLFAQVNENHTVDNLSFAKLPEEKCHLAYLFNSTNASSKRSHYLVLEPGQNDRNRNHSNQYKVSDALIAAYQQNLKKNRAFDEETEIGIMKKQFYDIFGSYDNILMRHSGSVGLVVFFQLDGEKLKNIGRTPYFKIPCRHQLTSLLGIRKQEKVDCASALFGFTAEKEPADQRKDVSIDTIPSYKSRLRFTSLDIELADAQTLELQKQPFLLPTPYASACAMYLEQPEGKSLQTYEQPARPQLNGYKYYHILPKQLKVQNQADWPNPNMLSYKPVIKYGSVRLLRGKIYFHNLTKAELGVLLLSLEPKQLLKTRQYGPQAEQFRSELEQAYDLVGGAKPYGYGKVKIEVRQLALEKSGRDFTSLVVDTEEIIADATWGEYIDAFIADMGGGNYFNTVHFRQYLQSKLELQDASELITWDQLPKKIAAETNSSQGGYPKHWRLKRTGKKS
>NZ_CP036259.1|WP_144348634.1|171495_171903_+|hypothetical-protein
MNELSAFDIAKLDMHDDYYFIAHTLDCVLLGRAKEPAHGRLLAAIQGGTLLEAHFFDTTREIFVTRSQDRLVQYEPLLHNQNAFAKDEIVSREYELEEKFRNQSGYYSLTVKEYINYDEDHLAYVEKTVLYCLGR
>NZ_CP036259.1|WP_144348633.1|170053_171499_+|hypothetical-protein
MWQRLIYEFAIRAVSPVRCGANETEVVKTPDGKPVILGNSLGGALRAYLQQGGVRTEDIEKAMGGEVESAEEKKKFLPSRIYISDGMIENYSDGEKQGLPRQEGTAVNPVYGAAEPHQKYMLEYLPAGTTVNFKIESDVWAGAGKEHNDALQPAELEKLVATWANGFAGGQLLLGGQKSNGFGRFTLDSLQARVVFLDNSQALDRYIFGSREKPAMEDVPWQAMPQYPLVPQCAVTFTLQGVFPYGVYQAFPVTADAGAQAAGARREPLTGLLKKRDNKDNGKHKEGQEQAYYIPAASLKGVLRHEVLRLLGRMMSDTADQGCGKNLTDLFGGTGSPGKLTVHDIVVTGTPVAVNRDSRQTDLPIYIKIDRLTGSSYDSALKRQQEIQGTAVISLELAVKPADDGYLNYIFPLVYVLRRLGAGLIPLGGRTVAGLGQFLAPTVNIGAGEETWQIETGPELSTGNRRQLEMWWESFAGWCRQ
>NZ_CP036259.1|WP_144348632.1|168423_170076_+|hypothetical-protein
MECYLVIEIINQEPLKIGAGGSKASQREPAKDYIPGSTIRGAWIGRLKQQGLFASAWQDILLKAACHNAYPYRNGRLYLPAPQHLRLNKHDWRQQKVVCAHALQSAAAVVPLAAGQTKERKNTLPYRFLTTYDGKTLSGLHVAKEYRLHHNTGRNRDREERDNLFRYEAIAAGQVFRTVLRCDPALVPLLMAVFPEEETPVYLGGSKSSGYGLCRWKKIGNVLACYQEAKVLLGLPDQDRRQAPGRDLWITCLSDVLVRNCYGQPVNAIPEEYIERISGEPVSLEKRFIHTGISEGYNATWQARYPKETTLKAGSVLHYTFAGELQGEQLQAIADRLESRLVGERAQDGFGWLGVNLPYPDVLQIGERPAEQEPERMFESNWRELAAAIEGDEHVRDTWELLAAGLAGAKNRWLQKIFLMDELAQGPESERFILAAQLKKHHLQNMKRWLNCRDLSPDRPYTRDNRQCSIAGCHFVAVLDYLNGAENTQLACYAQRYLQTAPGRLFYAGEKEQAERTEVTGREKRFISQLLEMGLKIRIGRKADVAKTDL
>NZ_CP036259.1|WP_144348631.1|167717_168446_+|hypothetical-protein
MAEPTYQIEVRLCSEAIFSSGEKECNLVQDRVLTDKYGLVYLHAKTFKGQLKRQAFWLLERYRSFDQALAQALLANMAVIFGMNQEETSLARLSPDRRLLYQPGIMHLGHLELDERIRQHLIGLQAGGEAALLSPFDLIEAQTNTRTGIQIADGAAKDGRLTTYHTVKQGMVFYSTVRFTADPEPYLADLQRIVCSLDRLGAGIHRGRGLVKAQFLINGQRIPLTSSKIQETGAPHGMLSGY
>NZ_CP036259.1|WP_144348630.1|166204_167758_+|hypothetical-protein
MAVYAYIDVARKQEFIYKNNKLRDNLHNSFLIKAITEELDRPDRPEDFCLSAYLEQAHPGQFAFVYSGGGNSIIRLDTPDIGKEFVRKFSSAVLRRHPDLELYISLVGDDGTDKQLIENLHKAADEQKNRRRSRCRRWTYGVEKIDETGQAVRKESKNSSETKAAREYLKEKFQALVPPAHFFITTELKDYKKDEEGKSYIGVIAIDGNKMGEMVAGASGFAEIKELSNTIEAIYREAVRDALFSCFAPDRERTRRICITPVLMAGDDICLIVEAEQAIEIAAAILRSIQMVSGRKKQNNSLLGRLIAGDYLTACAGVAIARYNYPFFELVQAAEGLCSRAKEALYKVPANKGSFIDWEVLPGPVPVARPQYARSGPVKEIFHVKPLRVDRTVPAEPVTAQGIYHYDAFIDFLRCVRQQVSTSSLAECRKHFYAGWEQYRLFLEFHKDSGKLTELAERIFGAKAGVWEYAALTTKQQDVPFSRTYILNDILETSPFIALQEEEEYGGTDLSNRGAAL
>NZ_CP036259.1|WP_144352681.1|165195_166188_+|hypothetical-protein
MADNKETKQEPDGSEVFEKIYENYQDLNRKMVNELNLSSIHGGLTGHCREEMWLNFFRGIIPQKFSLAQGVIIIDAYGNASREVDIAVYDEQYTPYVFRYNMLKFIPIEAVAVVIECKSVDPGNKQLTEWAKSIDALRTCRAGIARMATGYFAGLNNPTQTGTRPIKILACLKEVVRDGTWEACWQELQQSFDFIIAKKKDKDKYFELVVANKQKNLGWWGQQLNGISSASNDLQGLALERDIPESDPDSYKGLIFAADSSTLVKNTLADLEIEGNPILSLNLQLNQLLMLINNPMLFPHFAYAQQFNDIANLIKEKRQKQPHCEAEQNA
>NZ_CP036259.1|WP_170233085.1|162793_163114_-|hypothetical-protein
MLKGMLHAAFDQYVFTRVDNILNLAGTNDPGYTKTGGEVSAALDRVLALARALKAQHPELLDLVMDFEALTALESGQAAEIAYRQGLRDSSQIRQEFMTFLQQQYD
>NZ_CP036259.1|WP_144348628.1|161583_162348_+|phosphotransferase
MRINDLVNRIGFGSKAVVFRHENKAIKLFEPGYLETNAYFEVKLQQLALNASLPVPMVYGVTVSNDRVMIEMEYIKGKTLGDRMLADMRHIADFISRSVELQIEVHKVKAKDFPSQKDKLMRDIEAAKLLNKNQKLTLQNMLHSFISEDLLCHGDFHAFNIIQSNQGLVIIDWVDATCGCIAADVCRSFLLYLLTNKEVANLYLQHYCERSTSVTKEEVLKWLPIIAGARLSENNLHDAVNVLLHIVENGRLPS
>NZ_CP036259.1|WP_144348637.1|176856_178899_+|hypothetical-protein
MLAESIIRIGRPIKDGGMPCREKIRLLTDVSSENCKNFFRHVFLIELAGGDSCLQQLELGDMALENNKETFTVDSQRNVTFPIFYPNGGNPLHAQGIYPLPCYLLYDPHLKALGEKEQFKKEFLSPRLNNTLQYRDMTLSEKELLADQVAVLLAAQATEFISEDKQLGILMIYDARLNVFQEKQDWMGEDETLMWINESRLQPGRQLYLDGEEVLQCINQAKFYEAAELGSEKNAVSTFSNQPAAEVVSIYNKAWLWLSPTWDMPRSIYWQDDEWTKGIKVDAESYAAYFYGVQFLKEIQVPVASAVLKEMFAPVTSVEAKKNMKATSFESIYGIPLVLPLTDGGSQQLFANYRRMLKKDSEKQSNSDLHLKVLAGIDRVVPEIGDEHRLTILYYSGDLSRGNMHIRAVIEDIVPSVAGKIEQILHDLKVSETGKIQLAFGVAEQAVYKTQTLPALLANAFGPGYVWETLQAALHKEPLRLERLRLTTARRLNELANKEDTWQMVQELIFYYSFLYFLHQYEQKILQKQGGVMILSDWDEFKALYSQGRLDLCHLASVEQLGFTAGLLLRQFHNSYYQKTGKDFVKQRVMKFGSKLTPAMIWKNGLLRCEELAQQWNMKLGANFRPVLAQALLGFLAKQDQLVPEKDSFMTAFWSGYLLYKADKKNDKTEEDGGNDNEQQ
>NZ_CP036259.1|WP_144348638.1|178885_179836_+|CRISPR-associated-protein
MNSSEILFIKAVKDGIPNRDPLNDSDARRLFPEEDGRISLSDVSIKRDVRDFVIAYENNGGATQKNHIFVQEKINDKGKLLGRGSLAELIARSVGAEKQAKDDMKSVLKDHCFDVRTFGIVYSVKPKFHLTGPVQFGWAHSLHPVDTQYVQGTVVMPSTDSNDEGEGKTQGTIWTSYTLPFAVFAMPAVINAKAAEHSGMTTADQELLLRALWQGTQHRQARGRGQQQPLILVHIEYNDPFYRIGYPEDLIAMAPDAAAWKAAGKQPSSLQDVVFDLTRLLAVVAEKREKIARCRIWLHPGVKISGTVEPFVQPLW
>NZ_CP036259.1|WP_144348639.1|179848_180535_+|CRISPR-associated-protein-Cas5
MKGLAFDVRGSIGHFRRPDTTATQMTYPFITPTAAKGLVGAILGVEDFVTADQVGIELLRPVRTVAQQMSMLGKGTGAAFNRPTTIELLVNPAYRIYYTGEEYTEQLATALAEERSVYTTYLGAAYALTKPVLHRIYPEVVRAAAAEQEIESKSVVPTALIREISLKTDRYYCRAGGYLRHYKGGRTFEKSVDFLYEKDGKSITFIPRADASPELMLAKFGEEFICLI
>NZ_CP036259.1|WP_144348640.1|180522_182952_+|CRISPR-associated-helicase-Cas3'
MPDLVPFAQCIARPEEQGNQNWLTDHLLGVRAAVETRLKQGRSPFAKDQLSIRLAGLAGICHDLVKSHVQWQLYIRGKRGRGPNHAPEGAFLFSYLGYHWLQAEKRWPEYAGIWLWLIRDIADHHGALKRFGEEQWLRAGQWDKMDLPGMAAFLRQVYPEFTIPHLAAEPLVQWAKDLYHIKKDAADRLDAGYSASPLELMKQLSCWREMTTALIAGDRFHVTPTEGGSFHKQDHARHDRLLDDFCQAAGDNSMAVVRNNAQRQILSQLAGDPWRRVYTLEMPTGYGKTITALRLAIWLGKEQGYEKIIYVAPYLSILEQTSSVIETVLQASVLEHHSLAVLPIDQTEQADKEMEAVEEEGKLHSGQLIMEAWASPIVCTSFQQWSKALFPGRAQDTLRRAFLHNSVVIIDEPQIFAAASWNVFLCGLESLAELYNLRIIFLSATMPPFAYGLSKQNLPGCLAVKPVERLERYQVKQAGEMDEQAVADYLTGYLPGKNNLSQAAILNTITDAYLVYKKLAAKVEGSALKFLHGLMIPLHKRVEIEKIKRFPNREKPERLYVVSTQIIEAGVDLSFNHIMRALPVLPSIVQAAGRVNRNFVGDLGLLTLMLFLRNGEKNTRSSIYDVCLQRLTDNLLQEKEVWLESELLELIKVYYQRMFARNSYETGKQAIQAAYEGDWPALGQQFKPFGEDYYKLPVFVPWQAGEGDAICFPERFVELQRRLQLDSPARIYELYEDRDYYSKMSFQSKKEFMILMNHYVVNVPAKLAFSLVGKEPYLANRIPCLLNNSDYDPVAGLAKRNVEGFDQFI
>NZ_CP036259.1|WP_144348641.1|182988_183498_+|CRISPR-associated-protein-Cas4
MDDFEFNITGTHIWYYYCCPREVWLMLHQVNPDEDDANMDLGRFIHEMTYGRDKSKEISLGNIRLDIVRQDKEGLVIGEVKKSSKYLKSARMQLAFYLAELKRRGIEATGELLFPKEKKKESVTLTADIEKELMKAIAAIHCIAAESRPPQARKIGLCKNCAYKEFCWA
>NZ_CP036259.1|WP_144348642.1|183515_184511_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFSNGQLRRKDNTIFFMNEEGEQKYIPVEDTAELMVFGEVDINKRFLEFCSQQEIIVHYFNNYGYYSGTFYPREHYNSGYMILRQAEAYLNMESRVSLAQKFVTGAAQNIRQVLKYYQNRDKEVGRQLQEIEELSTKIKETCDISVLMGIEGNIREYYYKAFDVIHGQSEFVFEGRSKRPPQNAMNTLISFGNSIVYSTVLSEIYKTHLDPRIGYLHATNFRRFSLNLDIAEIFKPILVDRVIFTLIGKKMISKRDFKKDSGGLMLKENGRRVFVEELENRLKTTITHRGIGNPVSYRRLMRLELYKLEKHLMGESVYEPFVTQW
>NZ_CP036259.1|WP_144348643.1|184572_184836_+|CRISPR-associated-endonuclease-Cas2
MFVIVVYDVGEKRVVKALKRCRKYLNWVQNSVFEGEISEANLTKLKMELDKIIVPDEDSVIFYTLRSTRYSDRQIMGLRKGGQDLII
>NZ_CP036259.1|WP_170233087.1|185433_185595_-|hypothetical-protein
MEGKPMRACSSVCIIIVVFILIDQCYSGLNWERLFIGGFIGTAIWTDCSRWLR
>NZ_CP036259.1|WP_144348644.1|185677_186073_-|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain
MRGFFTTDKSPEIHEDDRFHRLFITVGTIARPCCSQCRFTDIHRVADLTMADYFGIEKYSPAWFDLLGVSVILVNSPQGAALFAQCRQDLHTEERPKEETLNDKNVCVNPPPCLKTAACFGRITDVSAMNM
>NZ_CP036259.1|WP_144348645.1|186417_187458_-|M48-family-metalloprotease
MTLYLRRITGLLICFVIMINIYGLPLAAAAIISTNQEISIGAKVAEQLEKKHGLVDDAALQARIARIGTRLVAVSERKDLTYSFKVLNSKDVNALAAPGGFVYIFKGLVDYMPSDEELAGVIGHEIGHIVRRHSVKQIEKSLAVSVLFGAAFGDRGPLLQNLAQNAIMAGYSRKDEREADQQGFKQTHLAGYNPYSMLLTLQKLDDLPNKGSYGLFSSHPEPGARVKLVQKYMKDAKITPEVITDGKKAEVVDNGWRLPAFTVSLNGYKPLYRAYFTAGALYLAAADPGFSSSRFTVTHTAAGAVIYYKDQKITTLSPEDAAARGLTLNQLTNEFISKLKEWAPKR

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Crispr_ID: NZ_CP036259_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_4

174338-174962

TypeIII

Consensus_repeat	Method
GATTCTAGGCTACCTATTAGGATTTGAAAC	PILER-CR
GATTCTAGGCTACCTATTAGGATTTGAAAC	CRISPRCasFinder
GATTCTAGGCTACCTATTAGGATTTGAAAC	CRT

9 spacers

csm3gr7,csx10gr5,cas10,PD-DExK,cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

The CRISPR arrays of NZ_CP036259_4

>merge|NZ_CP036259|4|174338-174962|PILER-CR,CRISPRCasFinder,CRT
GATTCTAGGCTACCTATTAGGATTTGAAACAACTAAATCCGGAGTATTGCGCTATGGCTGAACGAGATTCTAGGCTACCTATTAGGATTTGAAACTCTGTGTACGGAAGAACAGAGCCTACTGGTCCTCTGGATTCTAGGCTACCTATTAGGATTTGAAACCACATCCGGTAGGACGATGATAATTTTCCTGTTACGATTCTAGGCTACCTATTAGGATTTGAAACTAGAAATAAAGGAAAAGTGTAACACTTATCTGTTTTGATTCTAGGCTACCTATTAGGATTTGAAACCACGCCTATGTACGTTTGGGCGTGATTTTATCTAAGATTCTAGGCTACCTATTAGGATTTGAAACTCTATACCTGAAATTCCAAGCATTGAGGGGCTATGCGATTCTAGGCTACCTATTAGGATTTGAAACTCATGCTCAGTAAAGGCGATGATTTAAGTATAGATGTGATTCTAGGCTACCTATTAGGATTTGAAACTCAGTACAGAGGCGGCGGCCGTGCAGGTGGTGGTGAGGGATTCTAGGCTACCTATTAGGATTTGAAACAAGTAATCTTTCTGGTTTTTCACCTGCTCCTGATCCGATTTTAGGCTACCTATAAAGAATTGAAACT

>NZ_CP036259|4|4|174338-174895|PILER-CR
GATTCTAGGCTACCTATTAGGATTTGAAAC	AACTAAATCCGGAGTATTGCGCTATGGCTGAACGA
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCTGTGTACGGAAGAACAGAGCCTACTGGTCCTCTG
GATTCTAGGCTACCTATTAGGATTTGAAAC	CACATCCGGTAGGACGATGATAATTTTCCTGTTAC
GATTCTAGGCTACCTATTAGGATTTGAAAC	TAGAAATAAAGGAAAAGTGTAACACTTATCTGTTTT
GATTCTAGGCTACCTATTAGGATTTGAAAC	CACGCCTATGTACGTTTGGGCGTGATTTTATCTAA
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCTATACCTGAAATTCCAAGCATTGAGGGGCTATGC
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCATGCTCAGTAAAGGCGATGATTTAAGTATAGATGT
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCAGTACAGAGGCGGCGGCCGTGCAGGTGGTGGTGAGG
GATTCTAGGCTACCTATTAGGATTTGAAAC

>NZ_CP036259|4|4|174338-174962|CRISPRCasFinder
GATTCTAGGCTACCTATTAGGATTTGAAAC	AACTAAATCCGGAGTATTGCGCTATGGCTGAACGA
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCTGTGTACGGAAGAACAGAGCCTACTGGTCCTCTG
GATTCTAGGCTACCTATTAGGATTTGAAAC	CACATCCGGTAGGACGATGATAATTTTCCTGTTAC
GATTCTAGGCTACCTATTAGGATTTGAAAC	TAGAAATAAAGGAAAAGTGTAACACTTATCTGTTTT
GATTCTAGGCTACCTATTAGGATTTGAAAC	CACGCCTATGTACGTTTGGGCGTGATTTTATCTAA
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCTATACCTGAAATTCCAAGCATTGAGGGGCTATGC
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCATGCTCAGTAAAGGCGATGATTTAAGTATAGATGT
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCAGTACAGAGGCGGCGGCCGTGCAGGTGGTGGTGAGG
GATTCTAGGCTACCTATTAGGATTTGAAAC	AAGTAATCTTTCTGGTTTTTCACCTGCTCCTGATCC
GATTTTAGGCTACCTATAAAGAATTGAAACT

>NZ_CP036259|4|4|174338-174961|CRT
GATTCTAGGCTACCTATTAGGATTTGAAAC	AACTAAATCCGGAGTATTGCGCTATGGCTGAACGA
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCTGTGTACGGAAGAACAGAGCCTACTGGTCCTCTG
GATTCTAGGCTACCTATTAGGATTTGAAAC	CACATCCGGTAGGACGATGATAATTTTCCTGTTAC
GATTCTAGGCTACCTATTAGGATTTGAAAC	TAGAAATAAAGGAAAAGTGTAACACTTATCTGTTTT
GATTCTAGGCTACCTATTAGGATTTGAAAC	CACGCCTATGTACGTTTGGGCGTGATTTTATCTAA
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCTATACCTGAAATTCCAAGCATTGAGGGGCTATGC
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCATGCTCAGTAAAGGCGATGATTTAAGTATAGATGT
GATTCTAGGCTACCTATTAGGATTTGAAAC	TCAGTACAGAGGCGGCGGCCGTGCAGGTGGTGGTGAGG
GATTCTAGGCTACCTATTAGGATTTGAAAC	AAGTAATCTTTCTGGTTTTTCACCTGCTCCTGATCC
GATTTTAGGCTACCTATAAAGAATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144352681.1\|165195_166188_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	unknown
NZ_CP036259.1\|WP_170233087.1\|185433_185595_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	gnl\|CDD\|274209
NZ_CP036259.1\|WP_144348627.1\|160529_161144_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|379721
NZ_CP036259.1\|WP_170233085.1\|162793_163114_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	gnl\|CDD\|187857
NZ_CP036259.1\|WP_144348634.1\|171495_171903_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|377130
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	csx10gr5	cls000715_csx10gr5_CAS-III-D	gnl\|CDD\|131722
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|366736
NZ_CP036259.1\|WP_144348644.1\|185677_186073_-\|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain	unknown	unknown	gnl\|CDD\|377356
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP036259.1\|WP_144348637.1\|176856_178899_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP036259.1\|WP_144352681.1\|165195_166188_+\|hypothetical-protein	PD-DExK	mkCas0090_PD-DExK_CAS-I:CAS-III	6.7e-27	88.3	0.0
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	cas10	mkCas0133_cas10_CAS-III	7.4e-61	201.1	0.0
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	csm3gr7	cd09726_csm3gr7_CAS-III-D	1.9e-20	68.7	0.0
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	1.3e-38	128.0	0.0
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	1.5e-42	140.5	0.0
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	3.8e-141	464.6	6.1
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	3.3e-52	173.0	2.5
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	1.5e-51	169.5	0.3
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	csx10gr5	cls000715_csx10gr5_CAS-III-D	2.8e-16	54.3	0.2
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	csm3gr7	mkCas0198_csm3gr7_CAS-III-A:CAS-III-D	1.4e-28	94.5	0.0
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	2e-60	199.3	0.0
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	2e-25	84.5	0.0
NZ_CP036259.1\|WP_144348637.1\|176856_178899_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	8.8e-286	944.4	0.5
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	1.2e-30	100.3	0.9

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.54992e-22
NZ_CP036259.1\|WP_144348630.1\|166204_167758_+\|hypothetical-protein	gnl\|CDD\|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	1.97018e-06
NZ_CP036259.1\|WP_144348627.1\|160529_161144_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|379721	pfam14907, NTP_transf_5, Uncharacterized nucleotidyltransferase. This family is likely to be an uncharacterized group of nucleotidyltransferases.	1.98554e-05
NZ_CP036259.1\|WP_144348633.1\|170053_171499_+\|hypothetical-protein	gnl\|CDD\|187857	cd09726, RAMP_I_III, CRISPR/Cas system-associated RAMP superfamily protein. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily proteins.	1.31869e-11
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.72446e-34
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.94311e-35
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.52316e-33
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.0003e-72
NZ_CP036259.1\|WP_144348632.1\|168423_170076_+\|hypothetical-protein	gnl\|CDD\|131722	TIGR02674, cas_cyan_RAMP_2, CRISPR-associated RAMP protein, Csx10 family. CRISPR is a widespread repeat family in prokaryotes. At least 45 different protein families occur in prokaryotes only when these repeats are present. This family, a minor CRISPR-associated protein family, seems largely restricted to the Cyanobacteria. It belongs to the RAMP superfamily (pfam03787).	8.69091e-10
NZ_CP036259.1\|WP_144348631.1\|167717_168446_+\|hypothetical-protein	gnl\|CDD\|377130	pfam03787, RAMPs, RAMP superfamily. The molecular function of these proteins is not yet known. However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	0.00603178
NZ_CP036259.1\|WP_144348628.1\|161583_162348_+\|phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	4.88102e-11
NZ_CP036259.1\|WP_144348644.1\|185677_186073_-\|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain	gnl\|CDD\|377356	pfam04432, FrhB_FdhB_C, Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminus. Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits,. The N-terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2) is also a member of this family. This region is often found in association with the 4Fe-4S binding domain, fer4 (pfam00037).	0.00265623
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	9.67947e-72
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.86885e-175
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.47909e-32

>NZ_CP036259.1|WP_170233086.1|171919_174031_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MENERPRNMDNRLNQLKAYKEVILPYDFVPFSATTYYPYQKTRTGSKGNRQAGNLLPGHDRKENNNVSGFVQYTLQPCSDLVLETREKLKGGYFVSGSQFRGRIRANLEILSASYPQFVNTTPLLYRDLAGDLSKLYREKLGLVKNKGIEHVVQAGFLIKNENDFYVIPAPKIGDKNFLSIKEHRLIQMQIDKSAKQFSPLFCWDSNKISTFARIQKQIDDMNEKVLQRRQLQFEMKKKYFGLVPNDSFIPYQQRLFAQVNENHTVDNLSFAKLPEEKCHLAYLFNSTNASSKRSHYLVLEPGQNDRNRNHSNQYKVSDALIAAYQQNLKKNRAFDEETEIGIMKKQFYDIFGSYDNILMRHSGSVGLVVFFQLDGEKLKNIGRTPYFKIPCRHQLTSLLGIRKQEKVDCASALFGFTAEKEPADQRKDVSIDTIPSYKSRLRFTSLDIELADAQTLELQKQPFLLPTPYASACAMYLEQPEGKSLQTYEQPARPQLNGYKYYHILPKQLKVQNQADWPNPNMLSYKPVIKYGSVRLLRGKIYFHNLTKAELGVLLLSLEPKQLLKTRQYGPQAEQFRSELEQAYDLVGGAKPYGYGKVKIEVRQLALEKSGRDFTSLVVDTEEIIADATWGEYIDAFIADMGGGNYFNTVHFRQYLQSKLELQDASELITWDQLPKKIAAETNSSQGGYPKHWRLKRTGKKS
>NZ_CP036259.1|WP_144348634.1|171495_171903_+|hypothetical-protein
MNELSAFDIAKLDMHDDYYFIAHTLDCVLLGRAKEPAHGRLLAAIQGGTLLEAHFFDTTREIFVTRSQDRLVQYEPLLHNQNAFAKDEIVSREYELEEKFRNQSGYYSLTVKEYINYDEDHLAYVEKTVLYCLGR
>NZ_CP036259.1|WP_144348633.1|170053_171499_+|hypothetical-protein
MWQRLIYEFAIRAVSPVRCGANETEVVKTPDGKPVILGNSLGGALRAYLQQGGVRTEDIEKAMGGEVESAEEKKKFLPSRIYISDGMIENYSDGEKQGLPRQEGTAVNPVYGAAEPHQKYMLEYLPAGTTVNFKIESDVWAGAGKEHNDALQPAELEKLVATWANGFAGGQLLLGGQKSNGFGRFTLDSLQARVVFLDNSQALDRYIFGSREKPAMEDVPWQAMPQYPLVPQCAVTFTLQGVFPYGVYQAFPVTADAGAQAAGARREPLTGLLKKRDNKDNGKHKEGQEQAYYIPAASLKGVLRHEVLRLLGRMMSDTADQGCGKNLTDLFGGTGSPGKLTVHDIVVTGTPVAVNRDSRQTDLPIYIKIDRLTGSSYDSALKRQQEIQGTAVISLELAVKPADDGYLNYIFPLVYVLRRLGAGLIPLGGRTVAGLGQFLAPTVNIGAGEETWQIETGPELSTGNRRQLEMWWESFAGWCRQ
>NZ_CP036259.1|WP_144348632.1|168423_170076_+|hypothetical-protein
MECYLVIEIINQEPLKIGAGGSKASQREPAKDYIPGSTIRGAWIGRLKQQGLFASAWQDILLKAACHNAYPYRNGRLYLPAPQHLRLNKHDWRQQKVVCAHALQSAAAVVPLAAGQTKERKNTLPYRFLTTYDGKTLSGLHVAKEYRLHHNTGRNRDREERDNLFRYEAIAAGQVFRTVLRCDPALVPLLMAVFPEEETPVYLGGSKSSGYGLCRWKKIGNVLACYQEAKVLLGLPDQDRRQAPGRDLWITCLSDVLVRNCYGQPVNAIPEEYIERISGEPVSLEKRFIHTGISEGYNATWQARYPKETTLKAGSVLHYTFAGELQGEQLQAIADRLESRLVGERAQDGFGWLGVNLPYPDVLQIGERPAEQEPERMFESNWRELAAAIEGDEHVRDTWELLAAGLAGAKNRWLQKIFLMDELAQGPESERFILAAQLKKHHLQNMKRWLNCRDLSPDRPYTRDNRQCSIAGCHFVAVLDYLNGAENTQLACYAQRYLQTAPGRLFYAGEKEQAERTEVTGREKRFISQLLEMGLKIRIGRKADVAKTDL
>NZ_CP036259.1|WP_144348631.1|167717_168446_+|hypothetical-protein
MAEPTYQIEVRLCSEAIFSSGEKECNLVQDRVLTDKYGLVYLHAKTFKGQLKRQAFWLLERYRSFDQALAQALLANMAVIFGMNQEETSLARLSPDRRLLYQPGIMHLGHLELDERIRQHLIGLQAGGEAALLSPFDLIEAQTNTRTGIQIADGAAKDGRLTTYHTVKQGMVFYSTVRFTADPEPYLADLQRIVCSLDRLGAGIHRGRGLVKAQFLINGQRIPLTSSKIQETGAPHGMLSGY
>NZ_CP036259.1|WP_144348630.1|166204_167758_+|hypothetical-protein
MAVYAYIDVARKQEFIYKNNKLRDNLHNSFLIKAITEELDRPDRPEDFCLSAYLEQAHPGQFAFVYSGGGNSIIRLDTPDIGKEFVRKFSSAVLRRHPDLELYISLVGDDGTDKQLIENLHKAADEQKNRRRSRCRRWTYGVEKIDETGQAVRKESKNSSETKAAREYLKEKFQALVPPAHFFITTELKDYKKDEEGKSYIGVIAIDGNKMGEMVAGASGFAEIKELSNTIEAIYREAVRDALFSCFAPDRERTRRICITPVLMAGDDICLIVEAEQAIEIAAAILRSIQMVSGRKKQNNSLLGRLIAGDYLTACAGVAIARYNYPFFELVQAAEGLCSRAKEALYKVPANKGSFIDWEVLPGPVPVARPQYARSGPVKEIFHVKPLRVDRTVPAEPVTAQGIYHYDAFIDFLRCVRQQVSTSSLAECRKHFYAGWEQYRLFLEFHKDSGKLTELAERIFGAKAGVWEYAALTTKQQDVPFSRTYILNDILETSPFIALQEEEEYGGTDLSNRGAAL
>NZ_CP036259.1|WP_144352681.1|165195_166188_+|hypothetical-protein
MADNKETKQEPDGSEVFEKIYENYQDLNRKMVNELNLSSIHGGLTGHCREEMWLNFFRGIIPQKFSLAQGVIIIDAYGNASREVDIAVYDEQYTPYVFRYNMLKFIPIEAVAVVIECKSVDPGNKQLTEWAKSIDALRTCRAGIARMATGYFAGLNNPTQTGTRPIKILACLKEVVRDGTWEACWQELQQSFDFIIAKKKDKDKYFELVVANKQKNLGWWGQQLNGISSASNDLQGLALERDIPESDPDSYKGLIFAADSSTLVKNTLADLEIEGNPILSLNLQLNQLLMLINNPMLFPHFAYAQQFNDIANLIKEKRQKQPHCEAEQNA
>NZ_CP036259.1|WP_170233085.1|162793_163114_-|hypothetical-protein
MLKGMLHAAFDQYVFTRVDNILNLAGTNDPGYTKTGGEVSAALDRVLALARALKAQHPELLDLVMDFEALTALESGQAAEIAYRQGLRDSSQIRQEFMTFLQQQYD
>NZ_CP036259.1|WP_144348628.1|161583_162348_+|phosphotransferase
MRINDLVNRIGFGSKAVVFRHENKAIKLFEPGYLETNAYFEVKLQQLALNASLPVPMVYGVTVSNDRVMIEMEYIKGKTLGDRMLADMRHIADFISRSVELQIEVHKVKAKDFPSQKDKLMRDIEAAKLLNKNQKLTLQNMLHSFISEDLLCHGDFHAFNIIQSNQGLVIIDWVDATCGCIAADVCRSFLLYLLTNKEVANLYLQHYCERSTSVTKEEVLKWLPIIAGARLSENNLHDAVNVLLHIVENGRLPS
>NZ_CP036259.1|WP_144348627.1|160529_161144_+|nucleotidyltransferase-family-protein
MDSRAKIVLAAQIEDPLKRQMRVAAIIATELEQKGTQAVLVGGSAVEFYTVANYLTRDIDFVVTKPDHIGEVMTGLGFKNDSGTWYLPEYQQVVVEFPKGPLDGSWERVQKVIGPDGTSVNIISVEDILIDRASGIRFWNDPDEWVKYIMVGNYDRIDWEYLEQRARDLQCDAVIQTSKEWAKEKREIFRQDSGDLQAEAEKKS
>NZ_CP036259.1|WP_144348636.1|175237_175972_+|CRISPR-associated-endoribonuclease-Cas6
MHLDIHFKPAGGRLVLPISYNYLLQGALYHSLHKELAAFLHEKGYTDGKRSFKLFSFSLLQGVYQLDRVKKNIAFDGEIKLTISSPMQDFCHSLVNILLATGNMRLGTQATEIEKINVRQLKVTGDQAVVKTLSPAVLYSTLLRPDGRKYTVYFQPGEADYGRLFSENLQKKYRAFWGTDAPAGNVTAKALGLPRLKVVNYKDIIIKGYAGKLLVTGPQELLQLAVDGGIGSKNSQGFGCVELQ
>NZ_CP036259.1|WP_144348637.1|176856_178899_+|hypothetical-protein
MLAESIIRIGRPIKDGGMPCREKIRLLTDVSSENCKNFFRHVFLIELAGGDSCLQQLELGDMALENNKETFTVDSQRNVTFPIFYPNGGNPLHAQGIYPLPCYLLYDPHLKALGEKEQFKKEFLSPRLNNTLQYRDMTLSEKELLADQVAVLLAAQATEFISEDKQLGILMIYDARLNVFQEKQDWMGEDETLMWINESRLQPGRQLYLDGEEVLQCINQAKFYEAAELGSEKNAVSTFSNQPAAEVVSIYNKAWLWLSPTWDMPRSIYWQDDEWTKGIKVDAESYAAYFYGVQFLKEIQVPVASAVLKEMFAPVTSVEAKKNMKATSFESIYGIPLVLPLTDGGSQQLFANYRRMLKKDSEKQSNSDLHLKVLAGIDRVVPEIGDEHRLTILYYSGDLSRGNMHIRAVIEDIVPSVAGKIEQILHDLKVSETGKIQLAFGVAEQAVYKTQTLPALLANAFGPGYVWETLQAALHKEPLRLERLRLTTARRLNELANKEDTWQMVQELIFYYSFLYFLHQYEQKILQKQGGVMILSDWDEFKALYSQGRLDLCHLASVEQLGFTAGLLLRQFHNSYYQKTGKDFVKQRVMKFGSKLTPAMIWKNGLLRCEELAQQWNMKLGANFRPVLAQALLGFLAKQDQLVPEKDSFMTAFWSGYLLYKADKKNDKTEEDGGNDNEQQ
>NZ_CP036259.1|WP_144348638.1|178885_179836_+|CRISPR-associated-protein
MNSSEILFIKAVKDGIPNRDPLNDSDARRLFPEEDGRISLSDVSIKRDVRDFVIAYENNGGATQKNHIFVQEKINDKGKLLGRGSLAELIARSVGAEKQAKDDMKSVLKDHCFDVRTFGIVYSVKPKFHLTGPVQFGWAHSLHPVDTQYVQGTVVMPSTDSNDEGEGKTQGTIWTSYTLPFAVFAMPAVINAKAAEHSGMTTADQELLLRALWQGTQHRQARGRGQQQPLILVHIEYNDPFYRIGYPEDLIAMAPDAAAWKAAGKQPSSLQDVVFDLTRLLAVVAEKREKIARCRIWLHPGVKISGTVEPFVQPLW
>NZ_CP036259.1|WP_144348639.1|179848_180535_+|CRISPR-associated-protein-Cas5
MKGLAFDVRGSIGHFRRPDTTATQMTYPFITPTAAKGLVGAILGVEDFVTADQVGIELLRPVRTVAQQMSMLGKGTGAAFNRPTTIELLVNPAYRIYYTGEEYTEQLATALAEERSVYTTYLGAAYALTKPVLHRIYPEVVRAAAAEQEIESKSVVPTALIREISLKTDRYYCRAGGYLRHYKGGRTFEKSVDFLYEKDGKSITFIPRADASPELMLAKFGEEFICLI
>NZ_CP036259.1|WP_144348640.1|180522_182952_+|CRISPR-associated-helicase-Cas3'
MPDLVPFAQCIARPEEQGNQNWLTDHLLGVRAAVETRLKQGRSPFAKDQLSIRLAGLAGICHDLVKSHVQWQLYIRGKRGRGPNHAPEGAFLFSYLGYHWLQAEKRWPEYAGIWLWLIRDIADHHGALKRFGEEQWLRAGQWDKMDLPGMAAFLRQVYPEFTIPHLAAEPLVQWAKDLYHIKKDAADRLDAGYSASPLELMKQLSCWREMTTALIAGDRFHVTPTEGGSFHKQDHARHDRLLDDFCQAAGDNSMAVVRNNAQRQILSQLAGDPWRRVYTLEMPTGYGKTITALRLAIWLGKEQGYEKIIYVAPYLSILEQTSSVIETVLQASVLEHHSLAVLPIDQTEQADKEMEAVEEEGKLHSGQLIMEAWASPIVCTSFQQWSKALFPGRAQDTLRRAFLHNSVVIIDEPQIFAAASWNVFLCGLESLAELYNLRIIFLSATMPPFAYGLSKQNLPGCLAVKPVERLERYQVKQAGEMDEQAVADYLTGYLPGKNNLSQAAILNTITDAYLVYKKLAAKVEGSALKFLHGLMIPLHKRVEIEKIKRFPNREKPERLYVVSTQIIEAGVDLSFNHIMRALPVLPSIVQAAGRVNRNFVGDLGLLTLMLFLRNGEKNTRSSIYDVCLQRLTDNLLQEKEVWLESELLELIKVYYQRMFARNSYETGKQAIQAAYEGDWPALGQQFKPFGEDYYKLPVFVPWQAGEGDAICFPERFVELQRRLQLDSPARIYELYEDRDYYSKMSFQSKKEFMILMNHYVVNVPAKLAFSLVGKEPYLANRIPCLLNNSDYDPVAGLAKRNVEGFDQFI
>NZ_CP036259.1|WP_144348641.1|182988_183498_+|CRISPR-associated-protein-Cas4
MDDFEFNITGTHIWYYYCCPREVWLMLHQVNPDEDDANMDLGRFIHEMTYGRDKSKEISLGNIRLDIVRQDKEGLVIGEVKKSSKYLKSARMQLAFYLAELKRRGIEATGELLFPKEKKKESVTLTADIEKELMKAIAAIHCIAAESRPPQARKIGLCKNCAYKEFCWA
>NZ_CP036259.1|WP_144348642.1|183515_184511_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFSNGQLRRKDNTIFFMNEEGEQKYIPVEDTAELMVFGEVDINKRFLEFCSQQEIIVHYFNNYGYYSGTFYPREHYNSGYMILRQAEAYLNMESRVSLAQKFVTGAAQNIRQVLKYYQNRDKEVGRQLQEIEELSTKIKETCDISVLMGIEGNIREYYYKAFDVIHGQSEFVFEGRSKRPPQNAMNTLISFGNSIVYSTVLSEIYKTHLDPRIGYLHATNFRRFSLNLDIAEIFKPILVDRVIFTLIGKKMISKRDFKKDSGGLMLKENGRRVFVEELENRLKTTITHRGIGNPVSYRRLMRLELYKLEKHLMGESVYEPFVTQW
>NZ_CP036259.1|WP_144348643.1|184572_184836_+|CRISPR-associated-endonuclease-Cas2
MFVIVVYDVGEKRVVKALKRCRKYLNWVQNSVFEGEISEANLTKLKMELDKIIVPDEDSVIFYTLRSTRYSDRQIMGLRKGGQDLII
>NZ_CP036259.1|WP_170233087.1|185433_185595_-|hypothetical-protein
MEGKPMRACSSVCIIIVVFILIDQCYSGLNWERLFIGGFIGTAIWTDCSRWLR
>NZ_CP036259.1|WP_144348644.1|185677_186073_-|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain
MRGFFTTDKSPEIHEDDRFHRLFITVGTIARPCCSQCRFTDIHRVADLTMADYFGIEKYSPAWFDLLGVSVILVNSPQGAALFAQCRQDLHTEERPKEETLNDKNVCVNPPPCLKTAACFGRITDVSAMNM

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Crispr_ID: NZ_CP036259_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_6

184982-185276

TypeIII

Consensus_repeat	Method
GTTTTTAGGCTACCTATGAGGAATTGAAACC	CRISPRCasFinder
GTTTTTAGGCTACCTATGAGGAATTGAAAC	CRT

4 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6,csm3gr7

The CRISPR arrays of NZ_CP036259_6

>merge|NZ_CP036259|6|184982-185276|CRISPRCasFinder,CRT
GTTTTTAGGCTACCTATGAGGAATTGAAACCGGTGTAAGGCTTACCACATATAGTACATAGGTCTGTTTTTAGGCTACCTATGAGGAATTGAAACCTTTCTGAACAGTGGATACCGCGAAAGCATTGGATTGTTTTTAGGCTACCTATGAGGAATTGAAACTTAGTAAGGAAAAGGCCGGGAAGATCAAAGCTCTGGTTTTTAGGCTACCTATGAGGAATTGAAACTTCTCCTATATGTGCTAAAGCTGGCCAGTAATAATTCCGTTTTTAGGCTACCTACGAGGATTTAAAAAC

>NZ_CP036259|6|6|184982-185276|CRISPRCasFinder
GTTTTTAGGCTACCTATGAGGAATTGAAACC	GGTGTAAGGCTTACCACATATAGTACATAGGTCT
GTTTTTAGGCTACCTATGAGGAATTGAAACC	TTTCTGAACAGTGGATACCGCGAAAGCATTGGATT
GTTTTTAGGCTACCTATGAGGAATTGAAACT	TAGTAAGGAAAAGGCCGGGAAGATCAAAGCTCTG
GTTTTTAGGCTACCTATGAGGAATTGAAACT	TCTCCTATATGTGCTAAAGCTGGCCAGTAATAATTCC
GTTTTTAGGCTACCTACGAGGATTTAAAAAC

>NZ_CP036259|6|6|184982-185275|CRT
GTTTTTAGGCTACCTATGAGGAATTGAAAC	CGGTGTAAGGCTTACCACATATAGTACATAGGTCT
GTTTTTAGGCTACCTATGAGGAATTGAAAC	CTTTCTGAACAGTGGATACCGCGAAAGCATTGGATT
GTTTTTAGGCTACCTATGAGGAATTGAAAC	TTAGTAAGGAAAAGGCCGGGAAGATCAAAGCTCTG
GTTTTTAGGCTACCTATGAGGAATTGAAAC	TTCTCCTATATGTGCTAAAGCTGGCCAGTAATAATTCC
GTTTTTAGGCTACCTACGAGGATTTAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP036259.1\|WP_170233087.1\|185433_185595_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP036259.1\|WP_144348648.1\|189579_190473_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_CP036259.1\|WP_144348649.1\|190678_191893_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP036259.1\|WP_144348650.1\|194359_195142_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|223880
NZ_CP036259.1\|WP_144348634.1\|171495_171903_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
NZ_CP036259.1\|WP_144348637.1\|176856_178899_+\|hypothetical-protein	cas8b1	mkCas0074_cas8b1_CAS-I-B	unknown
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_CP036259.1\|WP_144348647.1\|188424_189414_-\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|107206
NZ_CP036259.1\|WP_144348645.1\|186417_187458_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320692
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP036259.1\|WP_144348651.1\|195184_195736_-\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223728
NZ_CP036259.1\|WP_144348644.1\|185677_186073_-\|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain	unknown	unknown	gnl\|CDD\|377356
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP036259.1\|WP_144348646.1\|187643_188405_+\|transposase	unknown	unknown	gnl\|CDD\|376616
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902
NZ_CP036259.1\|WP_144352682.1\|192176_194288_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144348639.1\|179848_180535_+\|CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.54992e-22
NZ_CP036259.1\|WP_144348645.1\|186417_187458_-\|M48-family-metalloprotease	gnl\|CDD\|320692	cd07333, M48C_bepA_like, Peptidase M48C Ste24p bepA-like, integral membrane protein. This family contains peptidase M48C Ste24p protease bepA (formerly yfgC)-like proteins considered to be putative metallopeptidases, containing a zinc-binding motif, HEXXH, and a COOH-terminal ER retrieval signal (KKXX). They proteolytically remove the C-terminal three residues of farnesylated proteins. They are integral membrane proteins associated with the endoplasmic reticulum and golgi, binding one zinc ion per subunit. In eukaryotes, Ste24p is required for the first NH2-terminal proteolytic processing event within the a-factor precursor, which takes place after COOH-terminal CAAX modification (C is cysteine; A is usually aliphatic; X is one of several amino acids) is complete. Mutation studies have shown that the HEXXH protease motif, which is extracellular but adjacent to a transmembrane domain and therefore close to the membrane surface, is critical for Ste24p activity. Several members of this family also contain tetratricopeptide (TPR) repeat motifs, which are involved in a variety of functions including protein-protein interactions. BepA has been shown to possess protease activity and is responsible for the degradation of incorrectly folded LptD, an essential outer-membrane protein (OMP) involved in OM transport and assembly of lipopolysaccharide. Overexpression of the bepA protease causes abnormal biofilm architecture.	4.98086e-62
NZ_CP036259.1\|WP_144348648.1\|189579_190473_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.34752e-84
NZ_CP036259.1\|WP_144352682.1\|192176_194288_+\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	7.80271e-47
NZ_CP036259.1\|WP_144348649.1\|190678_191893_+\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.65747e-66
NZ_CP036259.1\|WP_144348636.1\|175237_175972_+\|CRISPR-associated-endoribonuclease-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	3.72446e-34
NZ_CP036259.1\|WP_144348650.1\|194359_195142_+\|TonB-family-protein	gnl\|CDD\|223880	COG0810, TonB, Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane].	1.2066e-11
NZ_CP036259.1\|WP_144348642.1\|183515_184511_+\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.86885e-175
NZ_CP036259.1\|WP_144348640.1\|180522_182952_+\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.94311e-35
NZ_CP036259.1\|WP_144348647.1\|188424_189414_-\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|107206	cd01563, Thr-synth_1, Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.	2.97477e-107
NZ_CP036259.1\|WP_144348641.1\|182988_183498_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	3.0003e-72
NZ_CP036259.1\|WP_144348643.1\|184572_184836_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.47909e-32
NZ_CP036259.1\|WP_144348651.1\|195184_195736_-\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.31897e-21
NZ_CP036259.1\|WP_144348644.1\|185677_186073_-\|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain	gnl\|CDD\|377356	pfam04432, FrhB_FdhB_C, Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminus. Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits,. The N-terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2) is also a member of this family. This region is often found in association with the 4Fe-4S binding domain, fer4 (pfam00037).	0.00265623
NZ_CP036259.1\|WP_144348638.1\|178885_179836_+\|CRISPR-associated-protein	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	9.67947e-72
NZ_CP036259.1\|WP_144348646.1\|187643_188405_+\|transposase	gnl\|CDD\|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	5.53581e-15
NZ_CP036259.1\|WP_170233086.1\|171919_174031_+\|TIGR03986-family-CRISPR-associated-RAMP-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	1.52316e-33

>NZ_CP036259.1|WP_144348643.1|184572_184836_+|CRISPR-associated-endonuclease-Cas2
MFVIVVYDVGEKRVVKALKRCRKYLNWVQNSVFEGEISEANLTKLKMELDKIIVPDEDSVIFYTLRSTRYSDRQIMGLRKGGQDLII
>NZ_CP036259.1|WP_144348642.1|183515_184511_+|type-I-B-CRISPR-associated-endonuclease-Cas1
MKKTLYIFSNGQLRRKDNTIFFMNEEGEQKYIPVEDTAELMVFGEVDINKRFLEFCSQQEIIVHYFNNYGYYSGTFYPREHYNSGYMILRQAEAYLNMESRVSLAQKFVTGAAQNIRQVLKYYQNRDKEVGRQLQEIEELSTKIKETCDISVLMGIEGNIREYYYKAFDVIHGQSEFVFEGRSKRPPQNAMNTLISFGNSIVYSTVLSEIYKTHLDPRIGYLHATNFRRFSLNLDIAEIFKPILVDRVIFTLIGKKMISKRDFKKDSGGLMLKENGRRVFVEELENRLKTTITHRGIGNPVSYRRLMRLELYKLEKHLMGESVYEPFVTQW
>NZ_CP036259.1|WP_144348641.1|182988_183498_+|CRISPR-associated-protein-Cas4
MDDFEFNITGTHIWYYYCCPREVWLMLHQVNPDEDDANMDLGRFIHEMTYGRDKSKEISLGNIRLDIVRQDKEGLVIGEVKKSSKYLKSARMQLAFYLAELKRRGIEATGELLFPKEKKKESVTLTADIEKELMKAIAAIHCIAAESRPPQARKIGLCKNCAYKEFCWA
>NZ_CP036259.1|WP_144348640.1|180522_182952_+|CRISPR-associated-helicase-Cas3'
MPDLVPFAQCIARPEEQGNQNWLTDHLLGVRAAVETRLKQGRSPFAKDQLSIRLAGLAGICHDLVKSHVQWQLYIRGKRGRGPNHAPEGAFLFSYLGYHWLQAEKRWPEYAGIWLWLIRDIADHHGALKRFGEEQWLRAGQWDKMDLPGMAAFLRQVYPEFTIPHLAAEPLVQWAKDLYHIKKDAADRLDAGYSASPLELMKQLSCWREMTTALIAGDRFHVTPTEGGSFHKQDHARHDRLLDDFCQAAGDNSMAVVRNNAQRQILSQLAGDPWRRVYTLEMPTGYGKTITALRLAIWLGKEQGYEKIIYVAPYLSILEQTSSVIETVLQASVLEHHSLAVLPIDQTEQADKEMEAVEEEGKLHSGQLIMEAWASPIVCTSFQQWSKALFPGRAQDTLRRAFLHNSVVIIDEPQIFAAASWNVFLCGLESLAELYNLRIIFLSATMPPFAYGLSKQNLPGCLAVKPVERLERYQVKQAGEMDEQAVADYLTGYLPGKNNLSQAAILNTITDAYLVYKKLAAKVEGSALKFLHGLMIPLHKRVEIEKIKRFPNREKPERLYVVSTQIIEAGVDLSFNHIMRALPVLPSIVQAAGRVNRNFVGDLGLLTLMLFLRNGEKNTRSSIYDVCLQRLTDNLLQEKEVWLESELLELIKVYYQRMFARNSYETGKQAIQAAYEGDWPALGQQFKPFGEDYYKLPVFVPWQAGEGDAICFPERFVELQRRLQLDSPARIYELYEDRDYYSKMSFQSKKEFMILMNHYVVNVPAKLAFSLVGKEPYLANRIPCLLNNSDYDPVAGLAKRNVEGFDQFI
>NZ_CP036259.1|WP_144348639.1|179848_180535_+|CRISPR-associated-protein-Cas5
MKGLAFDVRGSIGHFRRPDTTATQMTYPFITPTAAKGLVGAILGVEDFVTADQVGIELLRPVRTVAQQMSMLGKGTGAAFNRPTTIELLVNPAYRIYYTGEEYTEQLATALAEERSVYTTYLGAAYALTKPVLHRIYPEVVRAAAAEQEIESKSVVPTALIREISLKTDRYYCRAGGYLRHYKGGRTFEKSVDFLYEKDGKSITFIPRADASPELMLAKFGEEFICLI
>NZ_CP036259.1|WP_144348638.1|178885_179836_+|CRISPR-associated-protein
MNSSEILFIKAVKDGIPNRDPLNDSDARRLFPEEDGRISLSDVSIKRDVRDFVIAYENNGGATQKNHIFVQEKINDKGKLLGRGSLAELIARSVGAEKQAKDDMKSVLKDHCFDVRTFGIVYSVKPKFHLTGPVQFGWAHSLHPVDTQYVQGTVVMPSTDSNDEGEGKTQGTIWTSYTLPFAVFAMPAVINAKAAEHSGMTTADQELLLRALWQGTQHRQARGRGQQQPLILVHIEYNDPFYRIGYPEDLIAMAPDAAAWKAAGKQPSSLQDVVFDLTRLLAVVAEKREKIARCRIWLHPGVKISGTVEPFVQPLW
>NZ_CP036259.1|WP_144348637.1|176856_178899_+|hypothetical-protein
MLAESIIRIGRPIKDGGMPCREKIRLLTDVSSENCKNFFRHVFLIELAGGDSCLQQLELGDMALENNKETFTVDSQRNVTFPIFYPNGGNPLHAQGIYPLPCYLLYDPHLKALGEKEQFKKEFLSPRLNNTLQYRDMTLSEKELLADQVAVLLAAQATEFISEDKQLGILMIYDARLNVFQEKQDWMGEDETLMWINESRLQPGRQLYLDGEEVLQCINQAKFYEAAELGSEKNAVSTFSNQPAAEVVSIYNKAWLWLSPTWDMPRSIYWQDDEWTKGIKVDAESYAAYFYGVQFLKEIQVPVASAVLKEMFAPVTSVEAKKNMKATSFESIYGIPLVLPLTDGGSQQLFANYRRMLKKDSEKQSNSDLHLKVLAGIDRVVPEIGDEHRLTILYYSGDLSRGNMHIRAVIEDIVPSVAGKIEQILHDLKVSETGKIQLAFGVAEQAVYKTQTLPALLANAFGPGYVWETLQAALHKEPLRLERLRLTTARRLNELANKEDTWQMVQELIFYYSFLYFLHQYEQKILQKQGGVMILSDWDEFKALYSQGRLDLCHLASVEQLGFTAGLLLRQFHNSYYQKTGKDFVKQRVMKFGSKLTPAMIWKNGLLRCEELAQQWNMKLGANFRPVLAQALLGFLAKQDQLVPEKDSFMTAFWSGYLLYKADKKNDKTEEDGGNDNEQQ
>NZ_CP036259.1|WP_144348636.1|175237_175972_+|CRISPR-associated-endoribonuclease-Cas6
MHLDIHFKPAGGRLVLPISYNYLLQGALYHSLHKELAAFLHEKGYTDGKRSFKLFSFSLLQGVYQLDRVKKNIAFDGEIKLTISSPMQDFCHSLVNILLATGNMRLGTQATEIEKINVRQLKVTGDQAVVKTLSPAVLYSTLLRPDGRKYTVYFQPGEADYGRLFSENLQKKYRAFWGTDAPAGNVTAKALGLPRLKVVNYKDIIIKGYAGKLLVTGPQELLQLAVDGGIGSKNSQGFGCVELQ
>NZ_CP036259.1|WP_170233086.1|171919_174031_+|TIGR03986-family-CRISPR-associated-RAMP-protein
MENERPRNMDNRLNQLKAYKEVILPYDFVPFSATTYYPYQKTRTGSKGNRQAGNLLPGHDRKENNNVSGFVQYTLQPCSDLVLETREKLKGGYFVSGSQFRGRIRANLEILSASYPQFVNTTPLLYRDLAGDLSKLYREKLGLVKNKGIEHVVQAGFLIKNENDFYVIPAPKIGDKNFLSIKEHRLIQMQIDKSAKQFSPLFCWDSNKISTFARIQKQIDDMNEKVLQRRQLQFEMKKKYFGLVPNDSFIPYQQRLFAQVNENHTVDNLSFAKLPEEKCHLAYLFNSTNASSKRSHYLVLEPGQNDRNRNHSNQYKVSDALIAAYQQNLKKNRAFDEETEIGIMKKQFYDIFGSYDNILMRHSGSVGLVVFFQLDGEKLKNIGRTPYFKIPCRHQLTSLLGIRKQEKVDCASALFGFTAEKEPADQRKDVSIDTIPSYKSRLRFTSLDIELADAQTLELQKQPFLLPTPYASACAMYLEQPEGKSLQTYEQPARPQLNGYKYYHILPKQLKVQNQADWPNPNMLSYKPVIKYGSVRLLRGKIYFHNLTKAELGVLLLSLEPKQLLKTRQYGPQAEQFRSELEQAYDLVGGAKPYGYGKVKIEVRQLALEKSGRDFTSLVVDTEEIIADATWGEYIDAFIADMGGGNYFNTVHFRQYLQSKLELQDASELITWDQLPKKIAAETNSSQGGYPKHWRLKRTGKKS
>NZ_CP036259.1|WP_144348634.1|171495_171903_+|hypothetical-protein
MNELSAFDIAKLDMHDDYYFIAHTLDCVLLGRAKEPAHGRLLAAIQGGTLLEAHFFDTTREIFVTRSQDRLVQYEPLLHNQNAFAKDEIVSREYELEEKFRNQSGYYSLTVKEYINYDEDHLAYVEKTVLYCLGR
>NZ_CP036259.1|WP_170233087.1|185433_185595_-|hypothetical-protein
MEGKPMRACSSVCIIIVVFILIDQCYSGLNWERLFIGGFIGTAIWTDCSRWLR
>NZ_CP036259.1|WP_144348644.1|185677_186073_-|Coenzyme-F420-hydrogenase/dehydrogenase,-beta-subunit-C-terminal-domain
MRGFFTTDKSPEIHEDDRFHRLFITVGTIARPCCSQCRFTDIHRVADLTMADYFGIEKYSPAWFDLLGVSVILVNSPQGAALFAQCRQDLHTEERPKEETLNDKNVCVNPPPCLKTAACFGRITDVSAMNM
>NZ_CP036259.1|WP_144348645.1|186417_187458_-|M48-family-metalloprotease
MTLYLRRITGLLICFVIMINIYGLPLAAAAIISTNQEISIGAKVAEQLEKKHGLVDDAALQARIARIGTRLVAVSERKDLTYSFKVLNSKDVNALAAPGGFVYIFKGLVDYMPSDEELAGVIGHEIGHIVRRHSVKQIEKSLAVSVLFGAAFGDRGPLLQNLAQNAIMAGYSRKDEREADQQGFKQTHLAGYNPYSMLLTLQKLDDLPNKGSYGLFSSHPEPGARVKLVQKYMKDAKITPEVITDGKKAEVVDNGWRLPAFTVSLNGYKPLYRAYFTAGALYLAAADPGFSSSRFTVTHTAAGAVIYYKDQKITTLSPEDAAARGLTLNQLTNEFISKLKEWAPKR
>NZ_CP036259.1|WP_144348646.1|187643_188405_+|transposase
MARKPREKSSSGIYHILLRGINRQSIFEEDEDRLKFLESLVKCKEISQCRIFAYCLMDNHIHILLQTGREPLGRMVQRLSSSYVIWYNGRHDRCGHLFQERFKSEPVDTDSYFLTVLRYIHQNPVQAKIVGDAAAYRWSSYHEYTGDKQFVDREYALAMFADTTAAAIARFVRFSNTANSDSCLELPASKISVSDDDFRNMIRQQFGIEPIQVARQTREQQDAILRALKAVEGAKIRQLARITGLAATRVWKA
>NZ_CP036259.1|WP_144348647.1|188424_189414_-|pyridoxal-phosphate-dependent-enzyme
MNFYCADCGQQYPLAGLDYQCRCGGLFNLMKAPGETVRTRVSLGEMPTPVLRRKLLHTEVYLKLDYLQPTGSFKDRGAFTLINKLQELGIREVVEDSSGNAGAAIAGYCAAAGIKCSIYLPADTSAGKIKQAAAYKANIVKVPGTRDDTARAILQAAQTAYYASHVYNPLFFEGTKSLAYEIWEQIGVPDYIFVPAGNGTMLLGAYIGFRELGRLPRIIAVQSRNCAPVVSRFHGHPAEDFAPTVAEGIAIREPRRLHEMIAAVKASNGDFIAVGDEQVLAAQARLGAMGIYVEPTAGVTVAGMLQYFATGHDKDLKIVVPLTGSGLKK
>NZ_CP036259.1|WP_144348648.1|189579_190473_-|LysR-family-transcriptional-regulator
MEWHQLEYFLTVAQLQHFTRAAGQLSISQPALSRSIARLEAELGVPLFERRGKNIRLNQFGKIFLQHISQAMQEIRAAKREIESIIHPDQGTVSLAFLHSQGAHIVPDLLGRFRAVHPNIRFRLYQNPSYLLLEQLEAGDIDLCLSTPPGSREDMEWTPLYTEELFVVVPADHRLAGRKSIALAAIAPEPIITLKSNFSLRILTDQLFREARLTPDITFEGEEIPTVAGLVEAGLGVAVIPRLPGLSNSRLAFLPISSPPCYRTIGLAWIKGRYAAPATLQFRDFVLSSFPANPDKR
>NZ_CP036259.1|WP_144348649.1|190678_191893_+|MFS-transporter
MQSIQDKNQIPWPTISALFLGSFVTFACLYSTQPLIPLFSEQFQVSPAAASLSVSLATGFMAVFMLIASWLSDARGRKVIMGGSLLATAVLQVFIGFSPNFTWLLVLRAVQGIMVAGFPAIAMAYIAEEFDPAISGLVMGIYISGNSVGGLTGRMVVGAVTDFFSWQSAMLSLGFICLAAGLWFWFTLPDSHNFSPRPRAVLTILRVMGNTIRKPPLLLLNLIGFLVMGSFVTVYNYIGYPLMAPPYNLSHTVVGLIFVIYLVGTFSSTWLGRLAITCGRARVLLLAIGIMATGGLISSGTGLALKIGGVAVFTFGFFGCYSVVSSWVGQCAGNDKAAASSLYLLFHYTGASVIGAWGGQFLGEYGWNGIVALTVAALLLALLLLAVLFLYTRKKEAAVYPQLR
>NZ_CP036259.1|WP_144352682.1|192176_194288_+|TonB-dependent-receptor
MVVLAAAIMMGICGPVSPASAEETTIELQDLYVNPDYVEIERLRDTKQIIVIKKEEIREKGYKGVSDVLKDIPSISVGATGLGDIDIRGQGSDQSVRNIQVLLDGAPITTFVSHPLSTNYDVVPIEQIEKIEIILGGGSVLYGSGAAGGIINITTNLRSMNKQNKTISSEWNTDGYRLNFNYGEKINDKLTTEIGYFKQDRDLYFKDTYKDSEYFSAGVQYDAGEGQRITFRMSHLAEEGQYIANIQPYKVAQAGRGYVPDYETYTIGLDADGHKITATRRPYLFADRSMDSYNLGYQKNLSRTWKFSSDLFYNTGDFMNSKYEDKRMDHETKGARLKFDHAYSEKGNLLFGLDIYEQTAEIGYNDYKLVSSAQKTYRAVPLSFNYNKKTNAAYLLHNATRGKYTFTQGLRREKIDWNFDKVGNNIDGAGTSERWNTAKELSLAYHYNDTGRVYARYERGYTTPDGIQITDEVRVNGSKKYVGTAAKDEIFDLYEIGLRDKLGISTVNLTLFHSNTDNQMNRLYLFDANGSLTMQTLNMLQTKRKGLELSLRQSFGKLAVQEGYAYLHGQSDYTSFGRNFLEENNGSIIDWTKSGLKKVPRHKGILKADYAFDDKLAVGLKYTYFGKYNNFLKDADKADGGVMQAHSLVDLDMKYKVSEDTEVYGGVTNLTNRRYYEYAGDSFGTIVPGSERTYYLGLKYAFN
>NZ_CP036259.1|WP_144348650.1|194359_195142_+|TonB-family-protein
MVECGHWKKSFLFSLGLHGVVIFLLAGLGFPFSPPKINNTGEINIQFIHVGEESMDGNGGLAEQAQHVAAPVIGRRAAAPTTVPGHETESRERFIQPDNGAEPVPPAEKNAGAGEITGTNANSAAAAGLYTGGEAGTATQAGGQGAGKGIFGNGNFLANGDGSYTALQAEGISYTIIRDADAKYPEEARSIGYSRVVSVQAKILVGLDGYVENVEILNSVPNLGFKESALKALRSMQFDPIYYKSHNVKMYFTKKIYFQP
>NZ_CP036259.1|WP_144348651.1|195184_195736_-|NAD(P)H-dependent-oxidoreductase
MGKNILVLTGSPRQGGNSDMLADAFIKGARAGGHTVAKFATAAKKIGGCRACEACWSKNTACSIQDDFAELEPLLESAATLVLASPLYWFGVSSHLKAAIDKFYAYTRPGCKRPLKIKESLLLICGADEGLGVFTGAIETYKGIVDYMKWQDKGILAVPSVSAKGAIVHTEALKQAEKLGAEI

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Crispr_ID: NZ_CP036259_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_8

1747987-1748064

Orphan

Consensus_repeat	Method
AATGTCAACAGCGGCGGCAGCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP036259_8

>merge|NZ_CP036259|8|1747987-1748064|CRISPRCasFinder
ACTGTGTCCAGCGGCGGCAGCGCCGTCGATACCGTCGTCAATGGCGGCAGTTTGGGTTTGAGCAGCGGCGGCAGCGTC

>NZ_CP036259|8|8|1747987-1748064|CRISPRCasFinder
ACTGTGTCCAGCGGCGGCAGCGCC	GTCGATACCGTCGTCAATGGCGGCAGTTTG
GGTTTGAGCAGCGGCGGCAGCGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_170233199.1\|1755701_1756130_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|315923
NZ_CP036259.1\|WP_144352802.1\|1757971_1758859_+\|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|180269
NZ_CP036259.1\|WP_144349874.1\|1742012_1745477_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|214908
NZ_CP036259.1\|WP_170233196.1\|1739452_1739695_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144349876.1\|1745977_1746358_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|223917
NZ_CP036259.1\|WP_144349864.1\|1737982_1738264_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|180266
NZ_CP036259.1\|WP_144349889.1\|1756345_1756804_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379267
NZ_CP036259.1\|WP_170233200.1\|1756829_1756976_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP036259.1\|WP_170233198.1\|1755146_1755317_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|372671
NZ_CP036259.1\|WP_144349887.1\|1755319_1755580_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_CP036259.1\|WP_144349883.1\|1754180_1754465_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_170233197.1\|1740234_1741908_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl\|CDD\|225387
NZ_CP036259.1\|WP_144349885.1\|1754710_1754902_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225382
NZ_CP036259.1\|WP_144349878.1\|1746450_1747101_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|223880
NZ_CP036259.1\|WP_144349868.1\|1738845_1739052_+\|transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP036259.1\|WP_144352801.1\|1745553_1745997_+\|TonB-system-energizer-ExbB	unknown	unknown	gnl\|CDD\|131852
NZ_CP036259.1\|WP_144349866.1\|1738542_1738764_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144349870.1\|1739175_1739463_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_170233071.1\|1756012_1756294_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144349881.1\|1752749_1753970_+\|autotransporter-strand-loop-strand-O-heptosyltransferase	unknown	unknown	gnl\|CDD\|275207

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_170233199.1\|1755701_1756130_-\|hypothetical-protein	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.2433e-16
NZ_CP036259.1\|WP_144352802.1\|1757971_1758859_+\|3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	3.19176e-148
NZ_CP036259.1\|WP_144349889.1\|1756345_1756804_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379267	pfam13565, HTH_32, Homeodomain-like domain.	2.48496e-09
NZ_CP036259.1\|WP_144349874.1\|1742012_1745477_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|214908	smart00912, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	2.8107e-20
NZ_CP036259.1\|WP_144349876.1\|1745977_1746358_+\|biopolymer-transporter-ExbD	gnl\|CDD\|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	5.15518e-29
NZ_CP036259.1\|WP_144349864.1\|1737982_1738264_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|180266	PRK05803, PRK05803, RNA polymerase sporulation sigma factor SigK.	3.6924e-33
NZ_CP036259.1\|WP_170233198.1\|1755146_1755317_-\|IS3-family-transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	1.12207e-06
NZ_CP036259.1\|WP_144349887.1\|1755319_1755580_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	6.12953e-14
NZ_CP036259.1\|WP_170233197.1\|1740234_1741908_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	1.24159e-102
NZ_CP036259.1\|WP_144349885.1\|1754710_1754902_-\|hypothetical-protein	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	0.00107223
NZ_CP036259.1\|WP_144349878.1\|1746450_1747101_+\|TonB-family-protein	gnl\|CDD\|223880	COG0810, TonB, Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane].	6.00371e-14
NZ_CP036259.1\|WP_144349868.1\|1738845_1739052_+\|transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	8.35286e-06
NZ_CP036259.1\|WP_144352801.1\|1745553_1745997_+\|TonB-system-energizer-ExbB	gnl\|CDD\|131852	TIGR02805, Biopolymer_transport_protein_ExbB, tonB-system energizer ExbB, group 2. Members of this protein family appear to be the ExbB protein of an ExbBD proton-transporting membrane complex that, by means of TonB, energizes transport by TonB-dependent receptors. Note that this family represents one of at least two distinct groups TolQ homologs designated ExbB - see also TIGR02797. Each group associates with a distinct group of ExbD proteins, and a single species may have two ExbB/ExbD/TonB systems. [Transport and binding proteins, Cations and iron carrying compounds].	3.58723e-37
NZ_CP036259.1\|WP_170233200.1\|1756829_1756976_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.1996e-08
NZ_CP036259.1\|WP_144349881.1\|1752749_1753970_+\|autotransporter-strand-loop-strand-O-heptosyltransferase	gnl\|CDD\|275207	TIGR04414, glycosyltransferase_tibC, autotransporter strand-loop-strand O-heptosyltransferase. Both Aah (autotransporter adhesin heptosyltransferase) and TibC (tib is enterotoxigenic invasion locus B) are protein O-heptosyltransferases that act on multiple sites from repeat regions of proteins exported by autotransporters. Aah glycosylates AIDA, or autotransporter adhesin involved in diffuse adherence, TibC acts on TibA, but TibC can replace Aah. [Protein fate, Protein modification and repair].	0

>NZ_CP036259.1|WP_144349878.1|1746450_1747101_+|TonB-family-protein
MGKLNLFHWLAISLLLHVSLISPLFLTTLHAAQQNRAERLRLELFGMVANRQLEERHESVAEPQQVSKVLPAPTPAPANYQTVKSPVLVEKVEEAPFKPVLAALHTADAATEQKQQTIRPVTEDSLQQYMARVTRKVRGHLTYPQEARGNGMKGTTTIAFTITSSGDIKGNSLRVQKSSGYAVLDSSALASAQVSAPFEEPPKEISIAIAVSFNIE
>NZ_CP036259.1|WP_144349876.1|1745977_1746358_+|biopolymer-transporter-ExbD
MDEKPFENMNVIPFVDIMLVLLTIVLVTSSFIASGRIPVNLPQASQSVAQADQAVAIEIEKTGTIYFDGKAVTLDSLKANLQPLGRETSFVIRADKDVTLQYFIDVVDLLKQMSFQKVAVQTKGHG
>NZ_CP036259.1|WP_144352801.1|1745553_1745997_+|TonB-system-energizer-ExbB
MHEQVLTNVIDYGIIGILLVLSIAVVAISLERYVFYRNLNITDFQDIKYLELILTRRLFLVASVGANAPYLGLLGTVLGIMLTFHNMGSDASAIDTGKIMTGLALALKATAVGLVVALLAVVLYNALLRKVRVLMLEWEIANGRKAV
>NZ_CP036259.1|WP_144349874.1|1742012_1745477_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MNRKWRREWGRQKKGQSAARSPTPGRSSLQTLAKIILPPVAAATLLLTAMLPAYANPTGGQITAGAGSISQSGNTTNISQTTNKLSIDWQSFNIGANETVNFLQPGASAIALNRVVGNNASSIYGKLNANGQVFLINTNGILFAPGSSVNVGGIVASTLNISDADFQKGKYDFTGNGGSVTNQGSITAGNGGYVALLGAQVSNQGVIVANQGTVALGAGSAATLDFHGDGLYSLAVTQAALDALAENHKLIQANGGQVFMTAKAASALAGSVLNNTGVIEAQSIGNANGIITLDGGSVGAVVNSGVLDASGKDAGQTGGTVKVLGNDLTLAAGTAIDVSGANGGGTVLLGGNEQGRGPEQNAAATTVANDVTINADAITAGDGGTIVVWSDGVTSFDGTASAKGGTSSGDGGFVETSGKRLKIGDNALITTAAANGKTGTWLLDPDGFTISAVGGDITGAELGSQLGSNNVTIASTSGRGYDGSINVNDTVNWSADTTLSLNATSKINVNAPITGSGASSGLALNAMLDININSPSSLQVNTLTANAAGNINFNAPQRWTNGGAWSFTGNNINVNDTVNWSAGILTLNAGKFVNLNAVMTAADQGSLAMNYNDDIDTSADADGNPTSKYGTLLGGLSPLFNKETGTYAGRIDFSGNTAGNPLTINGNQYTLITSIASPTLADGAANPHDISVINKNGGRGFYALAANLIAPDTDLTAYLSNNGAASYLITSISAGSVLEGLGNNIANLSLKNSSNTVAVSMIKNNYGTVRDLSLTNINFIGRRGATIFDSNDGRIINVAASGSLTISNPYNELATIIGGLVGGNSGLISGAYAKVDITAHSASNIGGLVGINYGVIQNSLAEGAVTLYADDYLWGSSAIGGFAGLNNGGSIFNSGATGNVTVGTDVNNGLAAVSGVGGFVGQNGYTFDAVIKPGYIDNSYATGNVSVSGGRVSNIGGFVGTSPATGSITNSASFGSVPAASSAVNSITNVGSFAGYLADTTVMAGNTYNPATSHSPNGVGSGNPSGLTSTTNTEPSSTQGPLSSNAQQAQQAAEARSEAKNLTDQAAAQQTTAGTYAAKDQAIAIAQASISEQSGQTEGNTLNPAEDRSEPDNLWQVSDDSSSYSADITAVQADGVEYQLEDAEYNDEDDDAKG
>NZ_CP036259.1|WP_170233197.1|1740234_1741908_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
MTPALVLVFSAASPTFAASPNTSQVAGQVADSVKQSQPPIQPKSDISIEVNEPQREKPAPPAGPTIKVSGFRITGQSIYSEDALQELLKDAVGKELTLGELQDIAGRTVAHYFRNQGFVVATAYIPVQEIRDGIVEIAVMPGKYSGIDIRNHSRLSNAAAAKFLSGIKAGDYVKRDELERVLLLLNDIGGIKVESVLTPGKEAGTTELVVDIKDANTVTATLLASNYGNRYTGSEQSNLDINFNNATGQGDVLSIGGSYTGHGMNNFSMNYMLPYGSRGWRLGVNYSRLNYTLKEEYAPLAANGKSETYGVYGQYPFVRSRNYDLYGQIGVATRRLVDDIDLFNSSNRRKTDFVTLGLNGISRDSRGINSFDLSLVSGRLNFTGKEDIFGNNWEVTDAQGAQTAGHYTKVNVTANRYQHLKDRLNLYLSIKGQLASKNLDSSEQLYLGGANGVRAYPQGEANGDEGYILTGELRYDLPTPKFQLAAFIDSGHAGGSKNNWKGSSPSRTLSGAGLGLILNNWQEYHLRVDYAWRLSSSQATTESDKHGRWWLAGVRYF
>NZ_CP036259.1|WP_170233196.1|1739452_1739695_+|hypothetical-protein
MKIKEQGYNACLSVLRLSKTHTNTRLETACELALPQFRSPRYRHLKAILDVAQYHTTLLYSLQSDQTRVEAFSTFCEENL
>NZ_CP036259.1|WP_144349870.1|1739175_1739463_+|hypothetical-protein
MLFKNNRYSCPYQYVGKEIDVKVTDTLVELYYRQERIATHRRFVDYVTNQWSTHPEDMPDQFQHSPWDDTGIRNWATSIGNSTANVIEQIFVSED
>NZ_CP036259.1|WP_144349868.1|1738845_1739052_+|transposase
MNARQLTSHLLHKPGVVTEVDWSGSKMAVVDRNTGEIIPVYLFVATLPYSQYSYIEPCFNMKRDTWLR
>NZ_CP036259.1|WP_144349866.1|1738542_1738764_+|hypothetical-protein
MNCHHMSKTSVGEVFRLAEENAISYNDVVDKRPEEVYRLLFPEKCEAVPIFATPNYEYAHNELSRTGVTLKLL
>NZ_CP036259.1|WP_144349864.1|1737982_1738264_+|helix-turn-helix-domain-containing-protein
MTLIDVLGTAPDIVGETVENLCEQERLNREIHRLTVREKWVLEMRFGIPNGSRKTQRDIAKILGISRSYVSRIEKHAINKLGKTLAVDEQPPK
>NZ_CP036259.1|WP_144349881.1|1752749_1753970_+|autotransporter-strand-loop-strand-O-heptosyltransferase
MNQTQEGTPSQPAKKPYAVFDAGPLTCKTDVSGLEFDFNYGVRVQVPAGNWRVKITDRDTFVTLYDDRADNALVSSTKKYYVNFGLEVYLDDKLILRHGMNLSGKKVLIKYPVGTLGDIIAWFPYAQAFKYKHDCEVYCAMAPEMADLFRPAYPELNFIGPDERPPEIYASYYMGIFFPCDDRVHQPVDWRIVGLQKTIPYLLGLPVEELRPSILPHNLERTIAEPYVCIAVQSSSQAKYWNNGNGWLEVIKHLKSKGYRVLCIDRENCHGAGSRWNTIPHGAEDFTGTLPLSQRVDLLYHADFFIGLSSGLSWLAWAVGKPVVMVSGFSLPSDEFYTPYRIINYHVCNGCWNDSTIEFDHTDFSWCPRHKNTDRQFECTRFINASYVNSVVDQLIRDHNFNPRKE
>NZ_CP036259.1|WP_144349883.1|1754180_1754465_+|hypothetical-protein
MNREIFADAISSIHVTGNLVRIDLMTVQPHLKSDNGQPVVEVNRRIVMPLEGFVQSLAVQENIIKQLIDAGVLKKNPPEGAGVVRLAEKKAEKQ
>NZ_CP036259.1|WP_144349885.1|1754710_1754902_-|hypothetical-protein
MAKGILYYSDKEAVILTLVERFTNNYLAIRIPGKTSEAIMDTMNMLYAEYGGCLTRYSRALQI
>NZ_CP036259.1|WP_170233198.1|1755146_1755317_-|IS3-family-transposase
MKGYPYDNAVAEATFKIFKTEFVYGRNFDSLPHLRHELAQYIDWFIIYEFMVRSIT
>NZ_CP036259.1|WP_144349887.1|1755319_1755580_-|DDE-type-integrase/transposase/recombinase
MVVVSDLTYVRVNYKWNYVCILIDLFNREIIGYSAGIHKDAQLVYDAFATVKTDLRKIQMFHSDRGSEFKSELIDEVLQPLILNVP
>NZ_CP036259.1|WP_170233199.1|1755701_1756130_-|hypothetical-protein
MQHFCIHRASKRRTKIDWALHIEELLDVFYPNAAKVRLVMDNLNTHSIASLHEAFAPEKALRLAKRLEIHYTPKHGSWLNIAEIELNVMTLQCLGRRIPTIDLLNRELSAWEQQRNSAGKTVDWHFTTAQARDKLKHLYPKL
>NZ_CP036259.1|WP_170233071.1|1756012_1756294_-|hypothetical-protein
MEDILEVYAMPYEETIPLICMDEQPYQLLDDLLKPLPMEPGKVRKENYEYVRQGACSIFVFTEPVKGVPKLIGRFTLRNYWMSFIQTQQKSGW
>NZ_CP036259.1|WP_144349889.1|1756345_1756804_-|helix-turn-helix-domain-containing-protein
MNKKYHVKLSDIERTTIQKILDNETTSKYIRKRCNVLLHTDENAGKPPKQEEIAKRCGVSDVTVYSLVKEYDTQGMEYCLRRRKYATPPNPPIVTGEKEARIIALACGAAPHGRARWTVRLLAQKVIELGIMETVSHETIRTALKKHNLSLT
>NZ_CP036259.1|WP_170233200.1|1756829_1756976_-|IS3-family-transposase
MRATGNHGVYGTRKIKKELQKLDYQISRRRIGRIMKKKGLVTCQSFEL
>NZ_CP036259.1|WP_144352802.1|1757971_1758859_+|3-hydroxybutyryl-CoA-dehydrogenase
MKKIFVIGAGLMGAGIAQVAIQSGYDVILNDISESTLANGATGIEERLNRSVAKGFMSHEEKDACMKRLTCSMELASAAECQFVIEAIYENFEAKRAVFEKLDVICPPETILSSNTSSISLTALSSVVKRPEKFIGMHFFSPVPVMKLLEIIRGLRTSEDTLSAAREVGERLEKVMVVAKDMPGFIVNRILIPMLNEAVQILDESIGTVEDIDNGMKCGCNHPMGPLALADMVGLDVLLAAIEVFYSELGDSKYRPAPLLRKMVKAGYLGRKSGAGFYLYEAGGKKLGVNPVLNQ

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP036259_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_7

1747480-1747897

Orphan

Consensus_repeat	Method
AATGTCAACAGCGGCGGCAGCGCG	CRISPRCasFinder

6 spacers

The CRISPR arrays of NZ_CP036259_7

>merge|NZ_CP036259|7|1747480-1747897|CRISPRCasFinder
GTTGTCAACAGCGGCGGCATTCAGAATGTCAACAGCGGCGGCAGCGCGTCCGGTACCACCGTCAGCGGCGGCGGCACGCAGAATGTCAACAGCGGCGGCAGCGCATCCGGTACCTACGTCAGCGGCGCTTATACTAACTACGCCGCCCAATATGGCATCCAAAATGTCAACAGCGGCGGCAGCGCGACCGATGCCATCATAACGCGGTACGGCACGCAGAATATCAACAGCGGCGGCAGCGCGTCCGGTACCACCGTCGACGGTTACAGCGCCACCCAAAATGTCAACAACGGCGGCAGCGCGGTCAATACCGTCCTTAACAACAGCGGTACTATGAATGTGTCCAGCGGCGGCGTTGCCGTCGATACTACCATCTACGTCAGCGGCAGGCAGAATGTGAGCAGCGGCGGCAGCGCGG

>NZ_CP036259|7|7|1747480-1747897|CRISPRCasFinder
GTTGTCAACAGCGGCGGCATTCAG	AATGTCAACAGCGGCGGCAGCGCGTCCGGTACCACCGTCAGCGGCGGCGGCACGCAG
AATGTCAACAGCGGCGGCAGCGCA	TCCGGTACCTACGTCAGCGGCGCTTATACTAACTACGCCGCCCAATATGGCATCCAA
AATGTCAACAGCGGCGGCAGCGCG	ACCGATGCCATCATAACGCGGTACGGCACGCAG
AATATCAACAGCGGCGGCAGCGCG	TCCGGTACCACCGTCGACGGTTACAGCGCCACCCAA
AATGTCAACAACGGCGGCAGCGCG	GTCAATACCGTCCTTAACAACAGCGGTACTATG
AATGTGTCCAGCGGCGGCGTTGCC	GTCGATACTACCATCTACGTCAGCGGCAGGCAG
AATGTGAGCAGCGGCGGCAGCGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_170233199.1\|1755701_1756130_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|315923
NZ_CP036259.1\|WP_144352802.1\|1757971_1758859_+\|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|180269
NZ_CP036259.1\|WP_144349874.1\|1742012_1745477_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|214908
NZ_CP036259.1\|WP_170233196.1\|1739452_1739695_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144349876.1\|1745977_1746358_+\|biopolymer-transporter-ExbD	unknown	unknown	gnl\|CDD\|223917
NZ_CP036259.1\|WP_144349864.1\|1737982_1738264_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|180266
NZ_CP036259.1\|WP_144349889.1\|1756345_1756804_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379267
NZ_CP036259.1\|WP_170233200.1\|1756829_1756976_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP036259.1\|WP_170233198.1\|1755146_1755317_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|372671
NZ_CP036259.1\|WP_144349887.1\|1755319_1755580_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_CP036259.1\|WP_144349883.1\|1754180_1754465_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_170233197.1\|1740234_1741908_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl\|CDD\|225387
NZ_CP036259.1\|WP_144349885.1\|1754710_1754902_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225382
NZ_CP036259.1\|WP_144349878.1\|1746450_1747101_+\|TonB-family-protein	unknown	unknown	gnl\|CDD\|223880
NZ_CP036259.1\|WP_144349868.1\|1738845_1739052_+\|transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP036259.1\|WP_144352801.1\|1745553_1745997_+\|TonB-system-energizer-ExbB	unknown	unknown	gnl\|CDD\|131852
NZ_CP036259.1\|WP_144349866.1\|1738542_1738764_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144349870.1\|1739175_1739463_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_170233071.1\|1756012_1756294_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144349881.1\|1752749_1753970_+\|autotransporter-strand-loop-strand-O-heptosyltransferase	unknown	unknown	gnl\|CDD\|275207

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_170233199.1\|1755701_1756130_-\|hypothetical-protein	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.2433e-16
NZ_CP036259.1\|WP_144352802.1\|1757971_1758859_+\|3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	3.19176e-148
NZ_CP036259.1\|WP_144349889.1\|1756345_1756804_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379267	pfam13565, HTH_32, Homeodomain-like domain.	2.48496e-09
NZ_CP036259.1\|WP_144349874.1\|1742012_1745477_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|214908	smart00912, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	2.8107e-20
NZ_CP036259.1\|WP_144349876.1\|1745977_1746358_+\|biopolymer-transporter-ExbD	gnl\|CDD\|223917	COG0848, ExbD, Biopolymer transport protein [Intracellular trafficking and secretion].	5.15518e-29
NZ_CP036259.1\|WP_144349864.1\|1737982_1738264_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|180266	PRK05803, PRK05803, RNA polymerase sporulation sigma factor SigK.	3.6924e-33
NZ_CP036259.1\|WP_170233198.1\|1755146_1755317_-\|IS3-family-transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	1.12207e-06
NZ_CP036259.1\|WP_144349887.1\|1755319_1755580_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	6.12953e-14
NZ_CP036259.1\|WP_170233197.1\|1740234_1741908_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	1.24159e-102
NZ_CP036259.1\|WP_144349885.1\|1754710_1754902_-\|hypothetical-protein	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	0.00107223
NZ_CP036259.1\|WP_144349878.1\|1746450_1747101_+\|TonB-family-protein	gnl\|CDD\|223880	COG0810, TonB, Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane].	6.00371e-14
NZ_CP036259.1\|WP_144349868.1\|1738845_1739052_+\|transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	8.35286e-06
NZ_CP036259.1\|WP_144352801.1\|1745553_1745997_+\|TonB-system-energizer-ExbB	gnl\|CDD\|131852	TIGR02805, Biopolymer_transport_protein_ExbB, tonB-system energizer ExbB, group 2. Members of this protein family appear to be the ExbB protein of an ExbBD proton-transporting membrane complex that, by means of TonB, energizes transport by TonB-dependent receptors. Note that this family represents one of at least two distinct groups TolQ homologs designated ExbB - see also TIGR02797. Each group associates with a distinct group of ExbD proteins, and a single species may have two ExbB/ExbD/TonB systems. [Transport and binding proteins, Cations and iron carrying compounds].	3.58723e-37
NZ_CP036259.1\|WP_170233200.1\|1756829_1756976_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.1996e-08
NZ_CP036259.1\|WP_144349881.1\|1752749_1753970_+\|autotransporter-strand-loop-strand-O-heptosyltransferase	gnl\|CDD\|275207	TIGR04414, glycosyltransferase_tibC, autotransporter strand-loop-strand O-heptosyltransferase. Both Aah (autotransporter adhesin heptosyltransferase) and TibC (tib is enterotoxigenic invasion locus B) are protein O-heptosyltransferases that act on multiple sites from repeat regions of proteins exported by autotransporters. Aah glycosylates AIDA, or autotransporter adhesin involved in diffuse adherence, TibC acts on TibA, but TibC can replace Aah. [Protein fate, Protein modification and repair].	0

>NZ_CP036259.1|WP_144349878.1|1746450_1747101_+|TonB-family-protein
MGKLNLFHWLAISLLLHVSLISPLFLTTLHAAQQNRAERLRLELFGMVANRQLEERHESVAEPQQVSKVLPAPTPAPANYQTVKSPVLVEKVEEAPFKPVLAALHTADAATEQKQQTIRPVTEDSLQQYMARVTRKVRGHLTYPQEARGNGMKGTTTIAFTITSSGDIKGNSLRVQKSSGYAVLDSSALASAQVSAPFEEPPKEISIAIAVSFNIE
>NZ_CP036259.1|WP_144349876.1|1745977_1746358_+|biopolymer-transporter-ExbD
MDEKPFENMNVIPFVDIMLVLLTIVLVTSSFIASGRIPVNLPQASQSVAQADQAVAIEIEKTGTIYFDGKAVTLDSLKANLQPLGRETSFVIRADKDVTLQYFIDVVDLLKQMSFQKVAVQTKGHG
>NZ_CP036259.1|WP_144352801.1|1745553_1745997_+|TonB-system-energizer-ExbB
MHEQVLTNVIDYGIIGILLVLSIAVVAISLERYVFYRNLNITDFQDIKYLELILTRRLFLVASVGANAPYLGLLGTVLGIMLTFHNMGSDASAIDTGKIMTGLALALKATAVGLVVALLAVVLYNALLRKVRVLMLEWEIANGRKAV
>NZ_CP036259.1|WP_144349874.1|1742012_1745477_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MNRKWRREWGRQKKGQSAARSPTPGRSSLQTLAKIILPPVAAATLLLTAMLPAYANPTGGQITAGAGSISQSGNTTNISQTTNKLSIDWQSFNIGANETVNFLQPGASAIALNRVVGNNASSIYGKLNANGQVFLINTNGILFAPGSSVNVGGIVASTLNISDADFQKGKYDFTGNGGSVTNQGSITAGNGGYVALLGAQVSNQGVIVANQGTVALGAGSAATLDFHGDGLYSLAVTQAALDALAENHKLIQANGGQVFMTAKAASALAGSVLNNTGVIEAQSIGNANGIITLDGGSVGAVVNSGVLDASGKDAGQTGGTVKVLGNDLTLAAGTAIDVSGANGGGTVLLGGNEQGRGPEQNAAATTVANDVTINADAITAGDGGTIVVWSDGVTSFDGTASAKGGTSSGDGGFVETSGKRLKIGDNALITTAAANGKTGTWLLDPDGFTISAVGGDITGAELGSQLGSNNVTIASTSGRGYDGSINVNDTVNWSADTTLSLNATSKINVNAPITGSGASSGLALNAMLDININSPSSLQVNTLTANAAGNINFNAPQRWTNGGAWSFTGNNINVNDTVNWSAGILTLNAGKFVNLNAVMTAADQGSLAMNYNDDIDTSADADGNPTSKYGTLLGGLSPLFNKETGTYAGRIDFSGNTAGNPLTINGNQYTLITSIASPTLADGAANPHDISVINKNGGRGFYALAANLIAPDTDLTAYLSNNGAASYLITSISAGSVLEGLGNNIANLSLKNSSNTVAVSMIKNNYGTVRDLSLTNINFIGRRGATIFDSNDGRIINVAASGSLTISNPYNELATIIGGLVGGNSGLISGAYAKVDITAHSASNIGGLVGINYGVIQNSLAEGAVTLYADDYLWGSSAIGGFAGLNNGGSIFNSGATGNVTVGTDVNNGLAAVSGVGGFVGQNGYTFDAVIKPGYIDNSYATGNVSVSGGRVSNIGGFVGTSPATGSITNSASFGSVPAASSAVNSITNVGSFAGYLADTTVMAGNTYNPATSHSPNGVGSGNPSGLTSTTNTEPSSTQGPLSSNAQQAQQAAEARSEAKNLTDQAAAQQTTAGTYAAKDQAIAIAQASISEQSGQTEGNTLNPAEDRSEPDNLWQVSDDSSSYSADITAVQADGVEYQLEDAEYNDEDDDAKG
>NZ_CP036259.1|WP_170233197.1|1740234_1741908_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
MTPALVLVFSAASPTFAASPNTSQVAGQVADSVKQSQPPIQPKSDISIEVNEPQREKPAPPAGPTIKVSGFRITGQSIYSEDALQELLKDAVGKELTLGELQDIAGRTVAHYFRNQGFVVATAYIPVQEIRDGIVEIAVMPGKYSGIDIRNHSRLSNAAAAKFLSGIKAGDYVKRDELERVLLLLNDIGGIKVESVLTPGKEAGTTELVVDIKDANTVTATLLASNYGNRYTGSEQSNLDINFNNATGQGDVLSIGGSYTGHGMNNFSMNYMLPYGSRGWRLGVNYSRLNYTLKEEYAPLAANGKSETYGVYGQYPFVRSRNYDLYGQIGVATRRLVDDIDLFNSSNRRKTDFVTLGLNGISRDSRGINSFDLSLVSGRLNFTGKEDIFGNNWEVTDAQGAQTAGHYTKVNVTANRYQHLKDRLNLYLSIKGQLASKNLDSSEQLYLGGANGVRAYPQGEANGDEGYILTGELRYDLPTPKFQLAAFIDSGHAGGSKNNWKGSSPSRTLSGAGLGLILNNWQEYHLRVDYAWRLSSSQATTESDKHGRWWLAGVRYF
>NZ_CP036259.1|WP_170233196.1|1739452_1739695_+|hypothetical-protein
MKIKEQGYNACLSVLRLSKTHTNTRLETACELALPQFRSPRYRHLKAILDVAQYHTTLLYSLQSDQTRVEAFSTFCEENL
>NZ_CP036259.1|WP_144349870.1|1739175_1739463_+|hypothetical-protein
MLFKNNRYSCPYQYVGKEIDVKVTDTLVELYYRQERIATHRRFVDYVTNQWSTHPEDMPDQFQHSPWDDTGIRNWATSIGNSTANVIEQIFVSED
>NZ_CP036259.1|WP_144349868.1|1738845_1739052_+|transposase
MNARQLTSHLLHKPGVVTEVDWSGSKMAVVDRNTGEIIPVYLFVATLPYSQYSYIEPCFNMKRDTWLR
>NZ_CP036259.1|WP_144349866.1|1738542_1738764_+|hypothetical-protein
MNCHHMSKTSVGEVFRLAEENAISYNDVVDKRPEEVYRLLFPEKCEAVPIFATPNYEYAHNELSRTGVTLKLL
>NZ_CP036259.1|WP_144349864.1|1737982_1738264_+|helix-turn-helix-domain-containing-protein
MTLIDVLGTAPDIVGETVENLCEQERLNREIHRLTVREKWVLEMRFGIPNGSRKTQRDIAKILGISRSYVSRIEKHAINKLGKTLAVDEQPPK
>NZ_CP036259.1|WP_144349881.1|1752749_1753970_+|autotransporter-strand-loop-strand-O-heptosyltransferase
MNQTQEGTPSQPAKKPYAVFDAGPLTCKTDVSGLEFDFNYGVRVQVPAGNWRVKITDRDTFVTLYDDRADNALVSSTKKYYVNFGLEVYLDDKLILRHGMNLSGKKVLIKYPVGTLGDIIAWFPYAQAFKYKHDCEVYCAMAPEMADLFRPAYPELNFIGPDERPPEIYASYYMGIFFPCDDRVHQPVDWRIVGLQKTIPYLLGLPVEELRPSILPHNLERTIAEPYVCIAVQSSSQAKYWNNGNGWLEVIKHLKSKGYRVLCIDRENCHGAGSRWNTIPHGAEDFTGTLPLSQRVDLLYHADFFIGLSSGLSWLAWAVGKPVVMVSGFSLPSDEFYTPYRIINYHVCNGCWNDSTIEFDHTDFSWCPRHKNTDRQFECTRFINASYVNSVVDQLIRDHNFNPRKE
>NZ_CP036259.1|WP_144349883.1|1754180_1754465_+|hypothetical-protein
MNREIFADAISSIHVTGNLVRIDLMTVQPHLKSDNGQPVVEVNRRIVMPLEGFVQSLAVQENIIKQLIDAGVLKKNPPEGAGVVRLAEKKAEKQ
>NZ_CP036259.1|WP_144349885.1|1754710_1754902_-|hypothetical-protein
MAKGILYYSDKEAVILTLVERFTNNYLAIRIPGKTSEAIMDTMNMLYAEYGGCLTRYSRALQI
>NZ_CP036259.1|WP_170233198.1|1755146_1755317_-|IS3-family-transposase
MKGYPYDNAVAEATFKIFKTEFVYGRNFDSLPHLRHELAQYIDWFIIYEFMVRSIT
>NZ_CP036259.1|WP_144349887.1|1755319_1755580_-|DDE-type-integrase/transposase/recombinase
MVVVSDLTYVRVNYKWNYVCILIDLFNREIIGYSAGIHKDAQLVYDAFATVKTDLRKIQMFHSDRGSEFKSELIDEVLQPLILNVP
>NZ_CP036259.1|WP_170233199.1|1755701_1756130_-|hypothetical-protein
MQHFCIHRASKRRTKIDWALHIEELLDVFYPNAAKVRLVMDNLNTHSIASLHEAFAPEKALRLAKRLEIHYTPKHGSWLNIAEIELNVMTLQCLGRRIPTIDLLNRELSAWEQQRNSAGKTVDWHFTTAQARDKLKHLYPKL
>NZ_CP036259.1|WP_170233071.1|1756012_1756294_-|hypothetical-protein
MEDILEVYAMPYEETIPLICMDEQPYQLLDDLLKPLPMEPGKVRKENYEYVRQGACSIFVFTEPVKGVPKLIGRFTLRNYWMSFIQTQQKSGW
>NZ_CP036259.1|WP_144349889.1|1756345_1756804_-|helix-turn-helix-domain-containing-protein
MNKKYHVKLSDIERTTIQKILDNETTSKYIRKRCNVLLHTDENAGKPPKQEEIAKRCGVSDVTVYSLVKEYDTQGMEYCLRRRKYATPPNPPIVTGEKEARIIALACGAAPHGRARWTVRLLAQKVIELGIMETVSHETIRTALKKHNLSLT
>NZ_CP036259.1|WP_170233200.1|1756829_1756976_-|IS3-family-transposase
MRATGNHGVYGTRKIKKELQKLDYQISRRRIGRIMKKKGLVTCQSFEL
>NZ_CP036259.1|WP_144352802.1|1757971_1758859_+|3-hydroxybutyryl-CoA-dehydrogenase
MKKIFVIGAGLMGAGIAQVAIQSGYDVILNDISESTLANGATGIEERLNRSVAKGFMSHEEKDACMKRLTCSMELASAAECQFVIEAIYENFEAKRAVFEKLDVICPPETILSSNTSSISLTALSSVVKRPEKFIGMHFFSPVPVMKLLEIIRGLRTSEDTLSAAREVGERLEKVMVVAKDMPGFIVNRILIPMLNEAVQILDESIGTVEDIDNGMKCGCNHPMGPLALADMVGLDVLLAAIEVFYSELGDSKYRPAPLLRKMVKAGYLGRKSGAGFYLYEAGGKKLGVNPVLNQ

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Crispr_ID: NZ_CP036259_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_9

1763032-1763112

Orphan

Consensus_repeat	Method
TGTTTCGACCTGGAGGTCTGTATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP036259_9

>merge|NZ_CP036259|9|1763032-1763112|CRISPRCasFinder
TGTTTCGACCTGGAGGTCTGTATCAGGTATAGTACCCTGTAAGAAACTTTTTGGTATTGTTTCGACCTGTAGGTCTGTATC

>NZ_CP036259|9|9|1763032-1763112|CRISPRCasFinder
TGTTTCGACCTGGAGGTCTGTATC	AGGTATAGTACCCTGTAAGAAACTTTTTGGTAT
TGTTTCGACCTGTAGGTCTGTATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_170233199.1\|1755701_1756130_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|315923
NZ_CP036259.1\|WP_144352802.1\|1757971_1758859_+\|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|180269
NZ_CP036259.1\|WP_144349899.1\|1765452_1766787_+\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NZ_CP036259.1\|WP_170233202.1\|1769969_1770818_+\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|377562
NZ_CP036259.1\|WP_144349889.1\|1756345_1756804_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379267
NZ_CP036259.1\|WP_144349908.1\|1779769_1780735_+\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224170
NZ_CP036259.1\|WP_144349900.1\|1767550_1768891_+\|GntP-family-permease	unknown	unknown	gnl\|CDD\|225330
NZ_CP036259.1\|WP_170233198.1\|1755146_1755317_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|372671
NZ_CP036259.1\|WP_144349887.1\|1755319_1755580_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_CP036259.1\|WP_144349901.1\|1772007_1772748_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|187594
NZ_CP036259.1\|WP_144349885.1\|1754710_1754902_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225382
NZ_CP036259.1\|WP_144349893.1\|1759198_1760203_+\|3-keto-5-aminohexanoate-cleavage-protein	unknown	unknown	gnl\|CDD\|377562
NZ_CP036259.1\|WP_170233204.1\|1774372_1775758_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226350
NZ_CP036259.1\|WP_144352805.1\|1779058_1779559_-\|transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP036259.1\|WP_144349906.1\|1776933_1778253_+\|gluconate-permease	unknown	unknown	gnl\|CDD\|237880
NZ_CP036259.1\|WP_170233203.1\|1773040_1774243_+\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP036259.1\|WP_144352804.1\|1770944_1771970_+\|2-dehydropantoate-2-reductase	unknown	unknown	gnl\|CDD\|235821
NZ_CP036259.1\|WP_170233200.1\|1756829_1756976_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
NZ_CP036259.1\|WP_144349895.1\|1761401_1762394_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NZ_CP036259.1\|WP_170233071.1\|1756012_1756294_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_170233199.1\|1755701_1756130_-\|hypothetical-protein	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.2433e-16
NZ_CP036259.1\|WP_144352802.1\|1757971_1758859_+\|3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	3.19176e-148
NZ_CP036259.1\|WP_144349899.1\|1765452_1766787_+\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	4.24002e-06
NZ_CP036259.1\|WP_170233202.1\|1769969_1770818_+\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|377562	pfam05853, BKACE, beta-keto acid cleavage enzyme. BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.	7.1119e-121
NZ_CP036259.1\|WP_144349889.1\|1756345_1756804_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379267	pfam13565, HTH_32, Homeodomain-like domain.	2.48496e-09
NZ_CP036259.1\|WP_144349908.1\|1779769_1780735_+\|3-hydroxyacyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	4.98545e-74
NZ_CP036259.1\|WP_144349900.1\|1767550_1768891_+\|GntP-family-permease	gnl\|CDD\|225330	COG2610, GntT, H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism].	7.48107e-58
NZ_CP036259.1\|WP_170233198.1\|1755146_1755317_-\|IS3-family-transposase	gnl\|CDD\|372671	pfam13683, rve_3, Integrase core domain.	1.12207e-06
NZ_CP036259.1\|WP_144349887.1\|1755319_1755580_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	6.12953e-14
NZ_CP036259.1\|WP_144349901.1\|1772007_1772748_+\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.59724e-120
NZ_CP036259.1\|WP_144349885.1\|1754710_1754902_-\|hypothetical-protein	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	0.00107223
NZ_CP036259.1\|WP_144349893.1\|1759198_1760203_+\|3-keto-5-aminohexanoate-cleavage-protein	gnl\|CDD\|377562	pfam05853, BKACE, beta-keto acid cleavage enzyme. BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.	1.12601e-96
NZ_CP036259.1\|WP_170233204.1\|1774372_1775758_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	9.01226e-133
NZ_CP036259.1\|WP_144352805.1\|1779058_1779559_-\|transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	1.96467e-15
NZ_CP036259.1\|WP_144349906.1\|1776933_1778253_+\|gluconate-permease	gnl\|CDD\|237880	PRK14984, PRK14984, gluconate transporter.	2.43271e-146
NZ_CP036259.1\|WP_170233203.1\|1773040_1774243_+\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	4.15362e-160
NZ_CP036259.1\|WP_144352804.1\|1770944_1771970_+\|2-dehydropantoate-2-reductase	gnl\|CDD\|235821	PRK06522, PRK06522, 2-dehydropantoate 2-reductase; Reviewed.	1.3191e-64
NZ_CP036259.1\|WP_144349895.1\|1761401_1762394_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	2.15107e-60
NZ_CP036259.1\|WP_170233200.1\|1756829_1756976_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.1996e-08

>NZ_CP036259.1|WP_144349895.1|1761401_1762394_-|alpha/beta-hydrolase-fold-domain-containing-protein
MKKMIVLVLLLVVATSFLASYGRKEKSNISYKVSPEMTAVKEQMKEMMKMHGMGKSGSIDYITLRETIDKASEKMPAEPGVTFTKGQLGGVPVELSAPEKLTGDNIILYIHGGGFTTGSALGSRGFASQLASEAGLRVYSLSYRLAPENPYPAAQNDCYTVYTRLLGKYPDKKIAVIGDSAGANLALVTTLKAMDDGITLPTSVTVYSPVVDLTGTIDRNKNSATDIIISADIDSEIKSYLKNNNPYDPYISPLYGNYKGFPPLKIVCDSAEVLTEDSERLAKKAKEAGVNVDLQKFEGTFHAFPITGKGTPESYKVLRDTAKFIKDHFN
>NZ_CP036259.1|WP_144349893.1|1759198_1760203_+|3-keto-5-aminohexanoate-cleavage-protein
MSELKNYLLGDYRETIDYVDKVSRYGLTKFAPLIISCAITGGVHGKESNPNLPETIEEQVQQSYDVYNAGASLIHIHVRDKNNLAVNTPKTEDYLEVNSLVREKCPEVIINNTCLGGRMLKPDGSASPQLLVSIGAKPEVASVDIASFSSTLKLAARKPPLSGRDNDETWDVSYLMTMGDAARTVELMNENGVKPELEMYDITNIKYISNLINKGLLKGPHWVQMIFNGTGIYPSVENMLSVTRLLPKDSLFSVIGIGAAQTAMITLAIALGHHVRVGLEDNVFYGPHQLATSNAQMVERVVRIAKELGRPIATPAQSREMLGLGAPRQYTYNK
>NZ_CP036259.1|WP_144352802.1|1757971_1758859_+|3-hydroxybutyryl-CoA-dehydrogenase
MKKIFVIGAGLMGAGIAQVAIQSGYDVILNDISESTLANGATGIEERLNRSVAKGFMSHEEKDACMKRLTCSMELASAAECQFVIEAIYENFEAKRAVFEKLDVICPPETILSSNTSSISLTALSSVVKRPEKFIGMHFFSPVPVMKLLEIIRGLRTSEDTLSAAREVGERLEKVMVVAKDMPGFIVNRILIPMLNEAVQILDESIGTVEDIDNGMKCGCNHPMGPLALADMVGLDVLLAAIEVFYSELGDSKYRPAPLLRKMVKAGYLGRKSGAGFYLYEAGGKKLGVNPVLNQ
>NZ_CP036259.1|WP_170233200.1|1756829_1756976_-|IS3-family-transposase
MRATGNHGVYGTRKIKKELQKLDYQISRRRIGRIMKKKGLVTCQSFEL
>NZ_CP036259.1|WP_144349889.1|1756345_1756804_-|helix-turn-helix-domain-containing-protein
MNKKYHVKLSDIERTTIQKILDNETTSKYIRKRCNVLLHTDENAGKPPKQEEIAKRCGVSDVTVYSLVKEYDTQGMEYCLRRRKYATPPNPPIVTGEKEARIIALACGAAPHGRARWTVRLLAQKVIELGIMETVSHETIRTALKKHNLSLT
>NZ_CP036259.1|WP_170233071.1|1756012_1756294_-|hypothetical-protein
MEDILEVYAMPYEETIPLICMDEQPYQLLDDLLKPLPMEPGKVRKENYEYVRQGACSIFVFTEPVKGVPKLIGRFTLRNYWMSFIQTQQKSGW
>NZ_CP036259.1|WP_170233199.1|1755701_1756130_-|hypothetical-protein
MQHFCIHRASKRRTKIDWALHIEELLDVFYPNAAKVRLVMDNLNTHSIASLHEAFAPEKALRLAKRLEIHYTPKHGSWLNIAEIELNVMTLQCLGRRIPTIDLLNRELSAWEQQRNSAGKTVDWHFTTAQARDKLKHLYPKL
>NZ_CP036259.1|WP_144349887.1|1755319_1755580_-|DDE-type-integrase/transposase/recombinase
MVVVSDLTYVRVNYKWNYVCILIDLFNREIIGYSAGIHKDAQLVYDAFATVKTDLRKIQMFHSDRGSEFKSELIDEVLQPLILNVP
>NZ_CP036259.1|WP_170233198.1|1755146_1755317_-|IS3-family-transposase
MKGYPYDNAVAEATFKIFKTEFVYGRNFDSLPHLRHELAQYIDWFIIYEFMVRSIT
>NZ_CP036259.1|WP_144349885.1|1754710_1754902_-|hypothetical-protein
MAKGILYYSDKEAVILTLVERFTNNYLAIRIPGKTSEAIMDTMNMLYAEYGGCLTRYSRALQI
>NZ_CP036259.1|WP_144349899.1|1765452_1766787_+|S-layer-homology-domain-containing-protein
MKKTLVTLLALVFVLSIASSVFAAPNNSFVDLPAKHWAYVAVQELARVGIIDGYGDGEFRGEKSMTRYEMAQIVYQAMQNSSKADAVQKALIDKLAAEFALELNNLDKRVAKLETKNNVGLTYESRIRYMGNEASTVKGTSQFDYRQRIHLNGAVNDKVAYTARLEAGGYFGNGSTGTIGFNRAFFNIKDFAGIDMITIGRFGTHGITNGLLNAKSMNNDGVIFTQKLSDVTTAQFMVADVATNSEFGLLNLNFKASKDLKLNIAYTDYGFGNVAASPLFVPTAWNNMGGNQIDVGLNYKHGGLYLMSEYVANKISEGAYSGTNPKAWMVQLATNPSTVIYPFAGIVNPAKAHDQGFLINYRNIDANAVPVMSAYAGASSYNGNAMAQALVNGMYTDDNVKALTVAYQNVFSKGVVFTAAYSDLKQKVGTLKDKEWDLSFQFFF
>NZ_CP036259.1|WP_144349900.1|1767550_1768891_+|GntP-family-permease
MRSEIRKRGDCFMTLSVLGIIVSLGFLIWLALRGFHIIVLAPAAVVIVSLFSGMDPFEALVGPYMKGFVNYAGKFYLIFLAGSVFGKFMEDCGAARSIALGILKVLGAKSQEKVLWAIAIITMVMTYGGISLFVVIFAVLPIARPLFKELNIPWHLFVAALILGLGSVTMTMLPGSPSIQNIMPTKYLGTTAMAGPVIGILASIIIIIFNVWYFKDQLRRCHARNENFEAPTSGMVSGEEFSSPHGLPNVWLCLLPPITVFIMLNVLKMDVVIALFGGVIATLILFWKFFNNKMQTINKGALNAVVPIVNTSADVGYGMAMAATSGFVVISDWLLNMGGHPILSLSLATNIVAGMTGSASGGLGIVLETLSAKYLALGVAPDLIHRIAVMSSGCFDAMPHSGATITVLAVCGLTHAQAYKHFWWAHIVATVLALIIVIPIGIVIYG
>NZ_CP036259.1|WP_170233202.1|1769969_1770818_+|3-keto-5-aminohexanoate-cleavage-protein
MIFIATKVFITAALTGAVTPKDLNEHIPTTPEEIAEDAYNCWKAGAAIVHLHMRDDVGRGTMEPARFKKTVELLRARKECDVIICCTSSGTFDFSQSRTAHFKSIPEIEMGSYDIGTMNWGCAQVFENSPQFLEELAKCYKEYDVKPELEIFDMGMIGNAKHYLKTGILDQPLYCQFVLGVLGGMESTVENLQYLVRHMPENSKWSAFGIGKGHLPIMYAALALGADGIRVGLEDNVMYSKGVKASNVMLVERAIRVVKEFGKEIATPAEAREMLGIKPLVR
>NZ_CP036259.1|WP_144352804.1|1770944_1771970_+|2-dehydropantoate-2-reductase
MRTAILGCGAMGTVLGAYMNKNGHETILIDNYMDHVKALNERGARIIRFADLTVPVRAITPDQMEGKYDLVFLFTKQTVNKEVLTQLLPFLNADSTVCTLQNGVPEPSVAEIVGKERTVGGTVLWGATFIEPGVSELTSDITKDSLFEIGEMDGVIGDRIKKVAKALEKMGPVIITDNLMGARWLKVMLNSCWSGMSASLGCTFGDIIDNPKASACMSYIAQEAVAICKTVGYTMPPFWGNDVTPMGIIDTEEEFKNSQMIFYNIISNSMRPAKASMLQDLEKGKLTEVGMINGFICDEGKKVGIATPFNDTVVKVVRGIEAGDLPISMDNLKYFDVPRFK
>NZ_CP036259.1|WP_144349901.1|1772007_1772748_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MRLQDKVAIVTGAGQGIGQKIAVRMAKEGAKVVVVDVNYDLCHNVKAEIEKAGDVALAIKCDVSKRDDVEDMVAETVNKFGTIDILINNAGITRDGMIMDLTDQQWDAVMNVDLKSVFLCSQTVLKHMIPKQRGKIINIASIAGEMGNVGQTNYAAAKAGVIGATKSLSKELARKNITVNAIAPGFIETEMTAILPDKVKYFFVKQIPLARMGKPEDIASGCVFLASDEADYITGQILRINGGWYV
>NZ_CP036259.1|WP_170233203.1|1773040_1774243_+|thiolase-family-protein
MLERVFIIAAKRTAIGKLSGTLKDVDPVDLAANLFKGILAESQISPDQIEQVHLGCCTHCQANEGVAPVIARQALIKAGMPLSVVSSTVDRACTSGTWAVKVGYDAIRLREADIVLVGGTEVMSRTPHLARGLRSGVRLGAATLEDPLYPLGYKGYEPVAAEVGQVSVEYGVTREMQDAWALRSQTRYQEALKAGKWKQEILPIEVKNKKSTVTFEQDEFPKADTTIESLSSLRTVFGSPTVTAGNAPGLNDGAAAMILVSETRLKELGIKPLAEVLDFEFAGGEPKYMGTVPGTAIKDLLKKNQLTIDQVSCIEINEAFAAVPLLSSIILGNKDDAAIEKIREKINVNGGAVAMGHPVGATGTRIIVTLLYELQRRGGGYGVASLCGGLAQGDAILIKV
>NZ_CP036259.1|WP_170233204.1|1774372_1775758_-|sigma-54-interacting-transcriptional-regulator
MDNNFYLEILEHTNIGIFVLDVNGNYLYVNDHYCGLLANKTREFYMNSSMPKLREQGYFKNGVWEQVLRKNAPVVALLTVTDKDSNQIHQLFVSGTPTFNSDGSIKYIFFIIESMENLNQRVQAGILNTHNCTDFSLVTKAPTTDIIAESPMMKELLVLLANVSKTDASILIVGPTGSGKEVLAEYAHRNSLRSKGPFISIDCASIPETLLESELLGYEKGAFTGASTQGKMGLIESANGGTLFLDEINSMPLGLQGKLLRVLETRTVKRLGSLNAKPIDFRLLCASNENLETLARNGNFRSDLYYRISVVPIHIPPLRERKEDIVPLAFFYLQYFCKKYTRMKVLSEELINTMLSYDWPGNVRELKNFIERIVVTSSDTDLQVETVPKSFLQGTVGKNELEQIRLPFSHEDTFSHRSYMEQCEKQLIQHALSQFKTPAKVAEILKLDLSNVYRKMRKYNL
>NZ_CP036259.1|WP_144349906.1|1776933_1778253_+|gluconate-permease
MPVFILLLGIVFIFVLISVLRLNAFLSLMLACIFVGVAEGLPLMKVIASIEAGLGGTLGHLAIILGLGAMLGRLMSDCGAAQKIALTLVNKFGRKNVKWAMALTGFIVGIALFWEVAFVILIPIVFTVATTAELPLLEVGLPALAAISVAHCFLPPHPGPVAIANIFHANIGLTLVYGLIISIPAVLIGGPLWHKLFRKWSIEIPQGLISTKIYKEEDLPGFGVSLITAMAPVILIIGSMIGEHIVAKGSGAAAFFKFIGNTDISLLISVFLALFTFGLQRGKKLPEIMSTIEASIKAIAMIMLVIGAGGAFKQVIIDSGIAQYIASLMVGVSLSPYVMAFIVTAFIRVAVGSSTVTVFTAAGILTSLAAMPEVNKELFVLTISAASMFGLPPTDAAFWMCKEYFNLSFGQTVKVVTGMTSVIALCGLAGVLALSLVIH
>NZ_CP036259.1|WP_144352805.1|1779058_1779559_-|transposase
MASGHGPGIGIVSAEQIIAETGTAMSHFRNQHAFSNWTGTAPGNNESAGKRKSGRTTHGNKTLKSTLTQCAKSAVKSKYSFFSAQYQRLASHRGKNRATMAVAHSMACDFLCSLRRGVQRPRRALLHSIQPREEDQFSHQATLQAWCSHPRRRYTKGFGGTARYCY
>NZ_CP036259.1|WP_144349908.1|1779769_1780735_+|3-hydroxyacyl-CoA-dehydrogenase-family-protein
MEQTNIRAVACVGVGVIGASFALQFAWKGYPVTLCDVAQAALEGAKKNARENLNVLIENGIITAAEALEIEGRMTYTTDLAEAVRNVQFIQESGPENYGMKQPLLAQIEAYTSPDTVIATSTSGLLVTKIAEQMVHPERLIGGHPYNPPHLIPLVEVAKGEKTKDWVVQKTCAFYKSCGKEPVVLNKEVSGFISNRLQVAVYREIIDLVQNDVCSLADADRALLYGPGLRWGIMGPSMIFHLAAGELGIGVTMERQRESLDERLKDMAAWKHFPKELAELTANGIQEALNQRTEKEGRTIDKARVYRDKMLLELLKLHNKL

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Crispr_ID: NZ_CP036259_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_10

2600627-2600729

Orphan

Consensus_repeat	Method
GCTCGCCTTCTTGGATTCTCTGCTTAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP036259_10

>merge|NZ_CP036259|10|2600627-2600729|CRISPRCasFinder
GCTCGCCTTCTTGGATTCTCTGCTTATCGCTACCGCTCAGAACTAAGCGATTCACCCAATCAGGCTTCGCCTAACAGCTCGCCTTCTTGGGTTCTCTGCTTAT

>NZ_CP036259|10|10|2600627-2600729|CRISPRCasFinder
GCTCGCCTTCTTGGATTCTCTGCTTAT	CGCTACCGCTCAGAACTAAGCGATTCACCCAATCAGGCTTCGCCTAACA
GCTCGCCTTCTTGGGTTCTCTGCTTAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144350660.1\|2595242_2596304_-\|SIR2-family-protein	unknown	unknown	gnl\|CDD\|379106
NZ_CP036259.1\|WP_144350662.1\|2597861_2598407_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144350658.1\|2593009_2593900_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_CP036259.1\|WP_144350665.1\|2606220_2607984_-\|DUF4080-domain-containing-protein	unknown	unknown	gnl\|CDD\|379119
NZ_CP036259.1\|WP_144350661.1\|2596370_2597861_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|273520
NZ_CP036259.1\|WP_144350659.1\|2593963_2594893_+\|class-II-fructose-1,6-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|376459
NZ_CP036259.1\|WP_144350666.1\|2608162_2608945_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NZ_CP036259.1\|WP_144350656.1\|2591810_2592155_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144352884.1\|2605271_2606237_-\|TIGR01212-family-radical-SAM-protein	unknown	unknown	gnl\|CDD\|224163
NZ_CP036259.1\|WP_144350664.1\|2601632_2601983_+\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|119344
NZ_CP036259.1\|WP_144350663.1\|2598617_2598818_+\|DUF378-domain-containing-protein	unknown	unknown	gnl\|CDD\|377214
NZ_CP036259.1\|WP_144350654.1\|2590071_2591184_-\|MgtC/SapB-family-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144350655.1\|2591196_2591448_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144350668.1\|2610984_2611284_+\|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl\|CDD\|379193
NZ_CP036259.1\|WP_144350667.1\|2609041_2610853_+\|oligoendopeptidase-F	unknown	unknown	gnl\|CDD\|341071
NZ_CP036259.1\|WP_144350670.1\|2612397_2613264_+\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NZ_CP036259.1\|WP_144350669.1\|2611393_2612380_+\|DNA-ligase	unknown	unknown	gnl\|CDD\|236599
NZ_CP036259.1\|WP_144352885.1\|2613280_2614177_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|240133
NZ_CP036259.1\|WP_170233243.1\|2604998_2605154_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144350657.1\|2592189_2592657_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144350660.1\|2595242_2596304_-\|SIR2-family-protein	gnl\|CDD\|379106	pfam13289, SIR2_2, SIR2-like domain. This family of proteins are related to the sirtuins.	0.000156162
NZ_CP036259.1\|WP_144350658.1\|2593009_2593900_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.81165e-88
NZ_CP036259.1\|WP_144350665.1\|2606220_2607984_-\|DUF4080-domain-containing-protein	gnl\|CDD\|379119	pfam13311, DUF4080, Protein of unknown function (DUF4080). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	3.25596e-46
NZ_CP036259.1\|WP_144350661.1\|2596370_2597861_-\|AAA-family-ATPase	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.318e-143
NZ_CP036259.1\|WP_144350659.1\|2593963_2594893_+\|class-II-fructose-1,6-bisphosphate-aldolase	gnl\|CDD\|376459	pfam01116, F_bP_aldolase, Fructose-bisphosphate aldolase class-II.	8.39473e-152
NZ_CP036259.1\|WP_144350666.1\|2608162_2608945_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	7.6286e-73
NZ_CP036259.1\|WP_144352884.1\|2605271_2606237_-\|TIGR01212-family-radical-SAM-protein	gnl\|CDD\|224163	COG1242, COG1242, Predicted Fe-S oxidoreductase [General function prediction only].	6.87044e-113
NZ_CP036259.1\|WP_144350664.1\|2601632_2601983_+\|ASCH-domain-containing-protein	gnl\|CDD\|119344	cd06552, ASCH_yqfb_like, ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	3.96109e-08
NZ_CP036259.1\|WP_144350663.1\|2598617_2598818_+\|DUF378-domain-containing-protein	gnl\|CDD\|377214	pfam04070, DUF378, Domain of unknown function (DUF378). Predicted transmembrane domain of unknown function. The majority of the family have two predicted transmembrane regions.	2.77593e-24
NZ_CP036259.1\|WP_144350667.1\|2609041_2610853_+\|oligoendopeptidase-F	gnl\|CDD\|341071	cd09608, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and includes oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid. This PepF family includes Streptococcus agalactiae PepB, a group B streptococcal oligopeptidase which has been shown to degrade a variety of bioactive peptides as well as the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly- Pro-Ala in vitro.	0
NZ_CP036259.1\|WP_144350668.1\|2610984_2611284_+\|zinc-ribbon-domain-containing-protein	gnl\|CDD\|379193	pfam13451, zf-trcl, Probable zinc-ribbon domain. This is a probable zinc-binding domain with two CxxC sequence motifs, found in various families of bacteria.	2.93155e-19
NZ_CP036259.1\|WP_144350670.1\|2612397_2613264_+\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	1.59908e-121
NZ_CP036259.1\|WP_144350669.1\|2611393_2612380_+\|DNA-ligase	gnl\|CDD\|236599	PRK09632, PRK09632, ATP-dependent DNA ligase; Reviewed.	2.57824e-103
NZ_CP036259.1\|WP_144352885.1\|2613280_2614177_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|240133	cd04863, MtLigD_Pol_like, MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. MtLigD is monomeric and contains an N-terminal Pol domain, a central phosphoesterase module, and a C-terminal ligase domain. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The MtLigD Pol domain is stimulated by manganese, is error-prone, and prefers adding rNTPs to dNTPs in vitro. The MtLigD Pol domain has been shown to prefer DNA gapped substrates containing a 5'-phosphate group at the gap.	5.87792e-124

>NZ_CP036259.1|WP_144350663.1|2598617_2598818_+|DUF378-domain-containing-protein
MDRIALILVIVGALNWLLVGLFSFDLVATIFGGQQSFLSRIVYSLVGLAGIYSMSLLFRDRSRSQQ
>NZ_CP036259.1|WP_144350662.1|2597861_2598407_-|hypothetical-protein
MARKNINWVVGGLTLMLTLASLFGGQLLWNKYAVVNPINNAVQSIKGVESVAVSRLNEQGDSKNIKIYVKLAQVANLQKLYAELEEALKQVHRPQRYELVIQDSRTPELEQFYHSIHYSVQEAVFTGNFTAMAGSIAAKAGSAGVEAQTYVDTKNIYLQMTKGTNEMYVVVTRDSNRAGVQ
>NZ_CP036259.1|WP_144350661.1|2596370_2597861_-|AAA-family-ATPase
MQYPEIICGIGAAILIFLAIQGIDLLPVFFLAGLAAAFWIVHNRRTGNKSFISAAKRTAEEQLVSFDDIGGQDMAKGELCEALEFVKDVERIKTLGIRPLKGILLNGPPGTGKTLLAKAAAQFTGSAFLAVSGSEFVEMYVGVGAQRVRQLFKQARDVAKRNDKTNAVIFIDEIEVLGGKRGQNAGHMEYDQTLNELLVQMDGISENDAIRVLVIGATNRIDILDSALLRPGRFDRQVKVDLPDKKGRLKVLQLHTRNKPLADDVSLADVANDTFGFSGAHLESVTNEAAILAFRESSGVITAQHLRSAVEKVIMGEKLDRIPNAEEKKRIAIHEAGHALVSEYTLPGSVASVNVAARGNALGYVRQTQQDDIYLYTADYINSKIAVAIAGALAEELFLGTRSTGAANDFKQAADMAKQIVFGGMSELGIVSPADIPQELLHNTITAIFKQVEAEVRTVLTDQQTPFTRIVDTLLAKEVISGAEVRAFIQGDEQAA
>NZ_CP036259.1|WP_144350660.1|2595242_2596304_-|SIR2-family-protein
MINTTILLGGGASAAEGAPVQNLLFKKYFKALREKKNYSDRKRVSELCDYFKQMFFIDVLQDDLDAIEFPTFEEAIGLLDLAVRKRQSFKEFDLENIAKSSNRIGFIRQYLVLLMAEVLEDRTAAVKGLHRVLVDRLSELGCLADTVFLSTNYDVLIDQALIGRNDIAVDYGIDFSNYQSPACSAHQHKPVINLYKVHGSLNWSYCPTCNTLKLLNCQQGLLRLHTEPSQALCANCQSIKMPVIVPPTFFKNMSNNFINIVWHKTETCLRDVSHIIFCGYSFPDADMHIKYLLKRIQTNRPDRLRITVINNYPGKKQEKIDEEQKRYTRFLGTGIRYTDNTFEDFCRQPENFL
>NZ_CP036259.1|WP_144350659.1|2593963_2594893_+|class-II-fructose-1,6-bisphosphate-aldolase
MSLVTSKDMFKKAYEGQYAVGAFNVNNMEIIQGIVDAAKEERAPLILQVSAGARKYAKHIYLMKLVEAAIEDSGLPICLHLDHGEDFEICKSCIDGGFTSVMIDGSKLPFEENIALTRKVVEYAHGRGVVVEAELGRLAGIEDAVNVSTKDATYTDPDQAVEFVERTGVDSLAIAIGTSHGAYKFKGESNLDFDRLATISRLLPAFPLVLHGASTVLPEFVEKCNNYGGQLKGAQGVPEDMLRRAGQLGVCKINIDTDLRLAMTASIREHLSKNPADFDPRQYLKPARAAITGMVKHKIRNVLNCSGRL
>NZ_CP036259.1|WP_144350658.1|2593009_2593900_+|RluA-family-pseudouridine-synthase
MPDFPVPPTCSPLPVKEFLRRQAGISLTLWRKIKHSGTLSLNGCPAATHDLVYPGDIVTATWPQATTITAEALPLAIAYEDEWLLAADKPAGMLVHPAAGQPSGTLANAVMHYYRQNNYACDFHPVNRLDRNTSGLVLIAKRPDIQHWLNQNQQHLLKTYLAAAAGRPQPDKGTLNMPIGRKPGSIIERQVTLAGQQAITHYNLLAAYKNASLLEIILATGRTHQIRVHFSHIGCPLLGDDLYGGPVNLIQRQALHAASLSLLHPITQQITEIISPLPQDLTDLLSQLGDQVTNML
>NZ_CP036259.1|WP_144350657.1|2592189_2592657_+|hypothetical-protein
MKKPFSRRLLTVDPSHMITLHQEAIEQLELMLTTVEAAEHTSDGVRDALNTMAATHWEGYLDVIHMICMHDEHLAAVMKKHDSKIIDYEPADTERHFYGNRLLLLSLLTGLVRRHRRFVYFYGLRSNPMGDYIKESIAREREHIAAIVGMIENMI
>NZ_CP036259.1|WP_144350656.1|2591810_2592155_+|hypothetical-protein
METKYPHWYGPEDKMCCDYPDKDMMCCDDQYMDDPMSYKMYRDNFKDRLLCFLGDEVIIGTDAMIDRKGSTFCGTICYVGCDYIIVNSTYCRRSISLHVPIKMIRFIAPFKGRR
>NZ_CP036259.1|WP_144350655.1|2591196_2591448_-|hypothetical-protein
MEFIKNSNFILMGFLVWLIIAPRAASPRYGELFLAYMTALLFSLIGSSEIMMQKPIAFFFTLGGVLAFCYVVARKTIRITIRK
>NZ_CP036259.1|WP_144350654.1|2590071_2591184_-|MgtC/SapB-family-protein
MAEKKPPGGGRGRDSNSGERAEVRYFKGEEQFERWRKEFVQHQDYELKLAAVSKLSYEPADYQTQLVRQAYGELKLTDYSHLAGQAKTKVESEYVYPIITRIAAIVFLLGILVILFSPVTLLLTAALGVAAGVSLYFTIKDRDAAIIRAEQAAEAEAFRRNEQERLVYEEAKKRHEELENTRITRIEKLLAGETSAVRSRLDEVLNQLRLPMVVEVDIDFHVNIPLIRVWLPPKTVIPRQTCEMLPSGRIQYQDKDSRVYNKQYFELCAAIMLQIAAAVLANIPSFQEAYAAGIVNSEFSDDCILAVRVARDKIENINSAANAIAGMQALDAVYECDTSLVLYPVDMLRPPEWEDIEQQMLKSLRVRIFK
>NZ_CP036259.1|WP_144350664.1|2601632_2601983_+|ASCH-domain-containing-protein
MFALNFQSPNHEKLLISRQKNCTIRPGDMRNTYPENSIVWITVGEKFKTKRKLYSAMIDRVLIKKFSDLTTHDLDHQNPEIKTKEELLNFFEKIYQKSIHSDDIVTVIYFSEIIEQ
>NZ_CP036259.1|WP_170233243.1|2604998_2605154_-|hypothetical-protein
MRKLQLLEQIDKLAALLHSHDLKDLNLTKGTVNEIRQKLDILTDEYIQCYC
>NZ_CP036259.1|WP_144352884.1|2605271_2606237_-|TIGR01212-family-radical-SAM-protein
MISGLRYNAYSEYLRQRYGEKVYKLPVSLPVTCPNRDGQCGHDGCVFCGEIGAGYENLPAWLTVSDQLSANKAHIAPKYKAKKFIPYFQNFSNTYLPVEQLKRHVIEACQEDIVAIALATRPDCISDRYLAMLAEVREKYGIDISIELGLQTVNYHTLAKINRGHTLAEFIDAAQRIKCWPIEVCAHLILNLPWDDMTDAIESAKIVSALRVDQVKLHALYIVKNTVMADWYQNGAITLISKEEYVTRVVAFLEHLHPDIVIQRLIGRAPAANTLFTNWQTGWWKIRDAIEEQLLTQDTWQGKKCLYLNGPAVRNMELGTI
>NZ_CP036259.1|WP_144350665.1|2606220_2607984_-|DUF4080-domain-containing-protein
MKVLLATLNAKYIHSSLALQDLAAYCQTPEWDIAVREYTVNNGLLEILSDIYTCQADIVGLACYIWNIEASLALAALIKQVQPQAVIVLGGPEVSYQPEDILAGNAAVDYIVLGEGEHTLKRLLALLFNNQAVNNSTGLAYRCQGAIVAGQPQIVARLDDIPFPYIAAEMTRFNNKIIYYESSRGCPFSCQYCLSSATTGVRFLSQERVISDLGFFIKQDVRQVKFVDRTFNARKEHYFPILQFLAGQTCRTNFHFEIAADIWDQEVVEFLQHVPPGRFQFEIGIQSTNEQTLAAIKRHNNWPRIAEHVSKVRSYGNIHLHLDLIVGLPYENMAVFAKSFDEAYSLQPEMLQLGFLKLLKGSGIRRKAAAHGYIYMEHAPYEVLGNNYLDYGQIRRLKLLAEVFEQVYNSARFIYSLPWLIALAGDGAFNFYYKLACYWEQHGYQLVAHSGKTLYKYMAEFCAALYPEARQNYLELLKFDALMSENGAVRPEFLPWNQLNQAATDQWAEYKNSFWRDTIRVRRYLPDFTFTTWRELKKTFHVEVFSIDIPACLNGAEHPADRKAAVLFSYKHTKPTYQVINDDDFWT
>NZ_CP036259.1|WP_144350666.1|2608162_2608945_+|N-acetylmuramoyl-L-alanine-amidase
MRIMIDGRYLPDNARVNRDLLITLRNMAKVLNWGIRYDAQRELVLINSKDSSMPRLPADNHADERSEEENARLAGKVICLDPGHGGSDLGTLGPTGTMEKDNTLAIALLLKEKLEKSGATIVMTRDTDADVAYTDATANEELGARVEAANQADADLFISIHNDAFASNTASGTTTFHYGDKDSVNLANAVQRCLAEKLGTKNRGARFASFYVLRYTNMPSILIEVAFISNAVEEMLLSSVDGRDNAAESICEGILKYFKV
>NZ_CP036259.1|WP_144350667.1|2609041_2610853_+|oligoendopeptidase-F
MSQTATALPARDEIQSEYKWQIEDIYASEQLWRADFAKVKSAIPTVANYKGTLAQSPATLAACLQLRDEINILAGKLFAYARLQRDENSANAKYQALVGKTESLLAETGAAAAFIKPEILAMPAAVLATYRQDQALAEYSFYFDNLIRQKQHILSPGEEEILARSVEITQAAETAFNMLAHADMTFPEIKGEDGKILTLSEGRYRALIMSADRRVRKDAFTGLFGAYHAFRNTFAATLSGCVKKNIFYARTRKYNTTLESSLADDNIAVGVYDNLLTTVNNNLAPLHRYIDLKKKALKLDKLHMYDLYTPLAPAVTFTVTYQEGQKLVQDSLAPLGPEYTGILQQGLTSGWIDVYENKGKQSGAYCWGVYGVHPFVLLNYNDRLEDVSTLAHEMGHAIHSYYSQATQPYATSQYTIFTAEVASTTNEILLNDFLLKTTKDPRKKLYLINQYLEMVRATVYRQTMFAEFEKLIYDQAENGETLTADLLEELWHALNVKYYGPAIVIDPEIDIEWARIPHFYANFYVYQYVTGFSAATTLAEQMLTKSDGAQERYLNFLKSGGSDYPLTILKNAGVDMFTPQPVELTLNKFANMLDELEKTITNS
>NZ_CP036259.1|WP_144350668.1|2610984_2611284_+|zinc-ribbon-domain-containing-protein
MDFQDKDLSCKECGSAFTFTASEQSFYAEKGFQNDPSRCPDCRAARKRQNGGRMGGGNVRPQREMFDATCSACGIQTQVPFRPTAGKPVYCRDCFQANR
>NZ_CP036259.1|WP_144350669.1|2611393_2612380_+|DNA-ligase
MPIIKPMLAKPGLLPDEQDKCSFEIKWDGIRALFYLEQNNYKLLSRNLKDITGQYPELHTLAKEAGSSYTDLILDGEIVAFDSSGLPSFSRLQHRMGLTQAQTIREMMAKVPAHYMIFDILLLNGHSLLHKTYSERRALLESLRLDGAHWQTPGYKTGDGREILAASRKLGLEGIIAKRLDSSYQPGKRSGAWLKIKNQHRQELLICGWVPGQGTRAGTIGALLIGYYDVLPQIAAARGVPQQLLYAGKAGTGFTLDFLAILSQRLELIKRQTNPFAQDPAVKNAHFVEPVLIGEFEFTEWTPNHTLRHPSFKGLREDKDPRQVIRED
>NZ_CP036259.1|WP_144350670.1|2612397_2613264_+|Ku-protein
MPRPMWSGSISFGLVNIPVKLYSAVKKKSIHFNQLRKSDGCRIRLKKICPSDGAEVPAENIVKGYEIAPDQYVVVTSNELEAIQPKNARTIAIEDFVDLGQIDPLYYDSCYYLTPDKGAGKAYTLLLAAMIKTGKVAIARVVMRNKEYLTAIRPAGKALALSTMHFADEIIAAGQLEELAIDVPEPDTRELAMAEQLIESLATGFQPDKYHNQYYQQVLEMLEKKAEGQTVTSQPEVKEGGKVIDLMAALEASISAIKNKNDSGGKGAKQNKAAKPIAAPRRKKASAQ
>NZ_CP036259.1|WP_144352885.1|2613280_2614177_+|ATP-dependent-DNA-ligase
MIDIGGHKLKISNLDKVFYPATGFTKGQMLDYYIRIAPVLLPHLNNRPLTVKRYPNGAQGKFFYQKECPVHHPDWVKTIPVWSGSNNRNINFCNAADLPTLVWAANLAALELHTSLSVAPAVHQPSFLVFDLDPGPPATIVDCAQVGLLLKEYFDRHKLQSFPKTSGSKGLQLYIPLNTAVSYEHTKHFARVLAGRFQGKYPGLIVANMKKSLRSGKVFIDWSQNDEHKTTVCVYSLRAKEHPTVSTPITWEEVVTLVDQKKPELLSFAADQVLQRTAKLGDLFAPVLQIKQKLPAIE

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Crispr_ID: NZ_CP036259_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_11

3103720-3103820

Orphan

Consensus_repeat	Method
CGCTCAGAACTAAGCGATTCACAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP036259_11

>merge|NZ_CP036259|11|3103720-3103820|CRISPRCasFinder
CGCTCAGAACTAAGCGATTCACACCAATCAGTCTTCGCCTCACGGCTTGCCTTCTTGGGTTCTCTGCTTATCGCTGTCGCTCAGAACTAAGCGATTCGCAC

>NZ_CP036259|11|11|3103720-3103820|CRISPRCasFinder
CGCTCAGAACTAAGCGATTCACAC	CAATCAGTCTTCGCCTCACGGCTTGCCTTCTTGGGTTCTCTGCTTATCGCTGT
CGCTCAGAACTAAGCGATTCGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144351059.1\|3092259_3093516_-\|hexokinase	unknown	unknown	gnl\|CDD\|240270
NZ_CP036259.1\|WP_144351058.1\|3090200_3091481_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NZ_CP036259.1\|WP_144351067.1\|3117700_3118756_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl\|CDD\|176195
NZ_CP036259.1\|WP_144351061.1\|3094340_3095600_-\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NZ_CP036259.1\|WP_144351054.1\|3084838_3085942_-\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|367104
NZ_CP036259.1\|WP_144351071.1\|3122182_3123313_-\|lipoate--protein-ligase-family-protein	unknown	unknown	gnl\|CDD\|319742
NZ_CP036259.1\|WP_144351064.1\|3113914_3114385_-\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP036259.1\|WP_144351063.1\|3111717_3113298_-\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271357
NZ_CP036259.1\|WP_144351068.1\|3119122_3120007_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|224769
NZ_CP036259.1\|WP_144351052.1\|3083982_3084426_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319914
NZ_CP036259.1\|WP_144351069.1\|3119999_3121073_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|225314
NZ_CP036259.1\|WP_144351056.1\|3086902_3087874_-\|arsenosugar-biosynthesis-arsenite-methyltransferase-ArsM	unknown	unknown	gnl\|CDD\|237007
NZ_CP036259.1\|WP_144351055.1\|3085983_3086790_-\|MIP-family-channel-protein	unknown	unknown	gnl\|CDD\|223653
NZ_CP036259.1\|WP_170233288.1\|3121116_3122199_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223717
NZ_CP036259.1\|WP_170233287.1\|3088252_3088495_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|183797
NZ_CP036259.1\|WP_144351060.1\|3093929_3094100_-\|Spo0E-family-sporulation-regulatory-protein-aspartic-acid-phosphatase	unknown	unknown	gnl\|CDD\|378175
NZ_CP036259.1\|WP_144351062.1\|3110387_3111692_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341239
NZ_CP036259.1\|WP_144351066.1\|3115713_3117630_+\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226350
NZ_CP036259.1\|WP_144351053.1\|3084422_3084812_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|131766
NZ_CP036259.1\|WP_144351065.1\|3114553_3115507_+\|D-2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240639

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144351059.1\|3092259_3093516_-\|hexokinase	gnl\|CDD\|240270	PTZ00107, PTZ00107, hexokinase; Provisional.	6.40732e-109
NZ_CP036259.1\|WP_144351058.1\|3090200_3091481_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.22718e-83
NZ_CP036259.1\|WP_144351067.1\|3117700_3118756_-\|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl\|CDD\|176195	cd08233, butanediol_DH_like, (2R,3R)-2,3-butanediol dehydrogenase. (2R,3R)-2,3-butanediol dehydrogenase, a zinc-dependent medium chain alcohol dehydrogenase, catalyzes the NAD(+)-dependent oxidation of (2R,3R)-2,3-butanediol and meso-butanediol to acetoin. BDH functions as a homodimer. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit.	7.50731e-178
NZ_CP036259.1\|WP_144351061.1\|3094340_3095600_-\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	3.03079e-151
NZ_CP036259.1\|WP_144351054.1\|3084838_3085942_-\|GTP-binding-protein	gnl\|CDD\|367104	pfam02492, cobW, CobW/HypB/UreG, nucleotide-binding domain. This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.	1.03214e-19
NZ_CP036259.1\|WP_144351071.1\|3122182_3123313_-\|lipoate--protein-ligase-family-protein	gnl\|CDD\|319742	cd16443, LplA, lipoate-protein ligase. Lipoate-protein ligase A (LplA) catalyzes the formation of an amide linkage between free lipoic acid and a specific lysine residue of the lipoyl domain in lipoate dependent enzymes, similar to the biotinylation reaction mediated by biotinyl protein ligase (BPL). The two step reaction includes activation of exogenously supplied lipoic acid at the expense of ATP to lipoyl-AMP and then transfer to the epsilon-amino group of a specific lysine residue of the lipoyl domain of the target protein.	1.46981e-48
NZ_CP036259.1\|WP_144351064.1\|3113914_3114385_-\|DoxX-family-membrane-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.54975e-14
NZ_CP036259.1\|WP_144351063.1\|3111717_3113298_-\|sodium:solute-symporter-family-protein	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	4.22433e-72
NZ_CP036259.1\|WP_144351068.1\|3119122_3120007_-\|radical-SAM-protein	gnl\|CDD\|224769	COG1856, COG1856, Uncharacterized homolog of biotin synthetase [Function unknown].	1.47743e-71
NZ_CP036259.1\|WP_144351052.1\|3083982_3084426_+\|VOC-family-protein	gnl\|CDD\|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.14413e-46
NZ_CP036259.1\|WP_144351069.1\|3119999_3121073_-\|radical-SAM-protein	gnl\|CDD\|225314	COG2516, COG2516, Biotin synthase-related enzyme [General function prediction only].	3.79608e-79
NZ_CP036259.1\|WP_144351056.1\|3086902_3087874_-\|arsenosugar-biosynthesis-arsenite-methyltransferase-ArsM	gnl\|CDD\|237007	PRK11873, arsM, arsenite methyltransferase.	6.43978e-38
NZ_CP036259.1\|WP_144351055.1\|3085983_3086790_-\|MIP-family-channel-protein	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	3.05243e-54
NZ_CP036259.1\|WP_170233288.1\|3121116_3122199_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|223717	COG0644, FixC, Dehydrogenases (flavoproteins) [Energy production and conversion].	6.07388e-49
NZ_CP036259.1\|WP_170233287.1\|3088252_3088495_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|183797	PRK12859, PRK12859, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	5.90965e-14
NZ_CP036259.1\|WP_144351060.1\|3093929_3094100_-\|Spo0E-family-sporulation-regulatory-protein-aspartic-acid-phosphatase	gnl\|CDD\|378175	pfam09388, SpoOE-like, Spo0E like sporulation regulatory protein. Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation. This is a family of Spo0E-like phosphatases. The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure.	6.85511e-05
NZ_CP036259.1\|WP_144351062.1\|3110387_3111692_-\|AMP-binding-protein	gnl\|CDD\|341239	cd05913, PaaK, Phenylacetate-CoA ligase (also known as PaaK). PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.	0
NZ_CP036259.1\|WP_144351066.1\|3115713_3117630_+\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|226350	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms].	1.09582e-149
NZ_CP036259.1\|WP_144351053.1\|3084422_3084812_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|131766	TIGR02719, transcriptional_regulator_PadR_family, poly-beta-hydroxybutyrate-responsive repressor. Members of this family are transcriptional regulatory proteins found in the vicinity of poly-beta-hydroxybutyrate (PHB) operons in several species of Bacillus. This protein appears to have repressor activity modulated by PHB itself. This protein belongs to the larger PadR family (see pfam03551). [Regulatory functions, DNA interactions].	2.96848e-20
NZ_CP036259.1\|WP_144351065.1\|3114553_3115507_+\|D-2-hydroxyacid-dehydrogenase	gnl\|CDD\|240639	cd12162, 2-Hacid_dh_4, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	7.44526e-126

>NZ_CP036259.1|WP_144351061.1|3094340_3095600_-|diaminopimelate-decarboxylase
MAEKEIPFTKEQLTEVIKEYPTPFHIYDEQAIRQNVRNLIKAFAWAPEFKEYFAVKATPNPYILQVLREEGLGADCSSLAELILAEKAGMSGEEIILTSNDTPAIEFKKARELGAIINLDDISHIDYLDKHAGIPDIISFRYNPGPLREGGNSIIGNPEESKYGLTRKQLLDAYRIMKNRGVKRFGLHTMVISNELDPNYFVETANMMFDLINEIYRTLDIKVEFVNFGGGIGIPYRPEQEPVNIMTISQGIKKAYETKIAANGLAPLKIAMECGRMITGPYGYLVSTVLHKKEIYKNYVGLDACMANLMRPALYGAYHHITVLGKEEWPLGYIYDVTGSLCENNDKFAVNRKLPMIDIGDVLVIHDAGAHGHAMGFNYNGKLRSAELMLKHDGSVQLIRRAETIEDYFSTLDFTGLDN
>NZ_CP036259.1|WP_144351060.1|3093929_3094100_-|Spo0E-family-sporulation-regulatory-protein-aspartic-acid-phosphatase
MSKNIEALNILDIIEYLRRQMNLLAASYGVSDPQVLETSQLLDSQISKYYRIQQDG
>NZ_CP036259.1|WP_144351059.1|3092259_3093516_-|hexokinase
MRDIAICFQHDMCNGLTGKASSLKLLPSFLGNPTGREQGQVIAVDFGGTNVRVLLVELAGNGQVNIIDKRSALLKDKNGKYDYTAASASGLELFDFIAGKISEVAPRGGTYPLGHTFSFPCRQHGVNEAVLISWTKEFKTSGVEGRNIGELLQAALKRKGSSHVKSLAIINDTTGTLLSTAYTDTATSIGSICGTGHNTCYLEPCHPLTGQPMIINLESGNFDGIQQTEYDRQLDQASERFGSQRLEKMASGQYLGELVRLIVHKLATDGHINSASDRLGVPYSVSTEDISPVLADESPALDAVANMAARCWGITGLEIGELAAIRAAARLVTKRSARLVAATWAGVLIKIDPMLTRRHTIAVDGSLYEKMPGYKPHLLEAISEIFSQNAKQITIKLSKDGSGIGAAIAAATVCNAKS
>NZ_CP036259.1|WP_144351058.1|3090200_3091481_+|MFS-transporter
MNKGTNQQSRLGLPVHYGWIIALITFLVLLIAGGIRSLPTVFIVPFEHYFGWNRAIITFPLAVNLLLYGLYGPVVAVLMELYGVRRIMLLALLLLSGGIGLSGWMQTPWQMTFLWGIIVGTGTGFLSTVVGSIVAVRWFVTHRGLVVGIFSAAGAAGQLIFLSLFSKLLAILSWQTVVWSISLLALTVAVFVALIMRNTPRDVGLLPYGASLEPALKPLPPVAAVALVLKVLKRALPVREFWLLAGSFFVCGATSNGLIGTHFIPACVDHGLLAMTAAGLLSVAGVFNVMGAAASGWLSDKFDNRWLLFWYYCLRGLSLLFLPFGLEQNNMSLLFFIVFYGLDWAATVPPTVRLTADVFGGQQGPVIFGWLMAIHQVGAALAAWGGGILHTWIGNYLATFAAGGALCLIAAGMVGVIRKEKQTMAE
>NZ_CP036259.1|WP_170233287.1|3088252_3088495_-|SDR-family-NAD(P)-dependent-oxidoreductase
MQAEIEQNGKTAGMYAADLSLDGAHKQLLDYAEAVCGQVDILINNAAHCELPDTILSTTAAVINRHFAVNVNAPVLLSKE
>NZ_CP036259.1|WP_144351056.1|3086902_3087874_-|arsenosugar-biosynthesis-arsenite-methyltransferase-ArsM
MGYLDTAQEVYKKAALTPQSGLCCVSSQDRFLPGLTIPGIMQAMNYGCGTTVHFGDLRPEETILYIGVGGGLEALEFAYFTRRPQAVIAVDKVPEMLEKARENFNLAAKMNEWFQQDFIELVQGDALSLPVAECSVDVAAQNCLFNIFEEADFTKALAEMHRVLKPGGRLYISDPITNNPMPEKLRQDERLRAMCLAGALRYQEYLDQVIGAGFGTIEIRQRRPFRVLARERYGLAEHIFLESVDIVAYKVPVPAGGARVFAGETLIYFGKERLRDEEGFIIPRDIPQPVCQKTAAYFRKLNRRDMVVTAPTYHYNGPRGTCC
>NZ_CP036259.1|WP_144351055.1|3085983_3086790_-|MIP-family-channel-protein
MEYSRDFIGEFLGTFLLVLFGCGSVAVSVLFNSHSGLLQIALIWGVGVSLAIYATRNLSCAHLNPAVTVAMVASKRMGLKKMPVYLIAQFIGAFFAGLILYFLFNPFIVAFETAQQIVRGTPESMKVAKMFGEYYQLPGSETVISMPLAIGAEAIGTFLLVLMIFSLTEGCNLGRPDDNVAPLFIGLSVSSVICLVAPLTQAGLNPARDFGPRMVAWIFGWGNAAFPDQAGGFFFVYILAPIIGALAAGLLFTRVLEPLMKKSACQCS
>NZ_CP036259.1|WP_144351054.1|3084838_3085942_-|GTP-binding-protein
MKTKLILVGGFLGAGKTTLLGEAACRLSQAGKQVGLITNDQAAELVDTVLLEYTNALVSEVSGSCFCCNFPGFTAAIAYITEKEAVDVIIAEPVGSCTDLSATILQPLKDKFADTLRVAPLSVLVDPQQLIHLLDGRVAGLHPSAVYILRKQLEEADFIIINKADRLSPATAAALQKRTAAEWPWAKVYVISAKSGDGLENWLNDVLQSAAAGKRLAEVDYDIYAEGEAVLGWLNTTVHLQHQSADWDSYANQLLNALQQRLAELPAAVGHVKLLVKTGSGFVLGNITGPDNLITVRGSAGVGQAATMTLNARAQMEPESLQAIVLEEISKAGGSAVIAEFAALKCLKPGHPKPTYRYNQIIAQVAE
>NZ_CP036259.1|WP_144351053.1|3084422_3084812_-|helix-turn-helix-transcriptional-regulator
MRKFSIRKKFNDCPCTGANLEKLIHPATLTLLTDAELHGYSIVQKLQDICMFQGKKPDPSGVYRCLKQMEQDGYVTAVWDLSNSGPAKRLYRITDDGLECLKTWINTLEDYRHSIGLFLDFARDRLQAH
>NZ_CP036259.1|WP_144351052.1|3083982_3084426_+|VOC-family-protein
MNRINLICLGVRNMEKSLQFYKDIGFKTYEKNSNPPIVFFDNQGTKLELYPIAGLASDINEKNPPPLTLGGFCGITLAINLKSAAEVDQLMETVAAADGIIAKKPAKFFWGGYSGYFQDPDGYYWEVAYSADWQFDHNDMLVIDENN
>NZ_CP036259.1|WP_144351062.1|3110387_3111692_-|AMP-binding-protein
MIWNTEAECLERSKMAEMQLTRLRHVVRRVYENVPFYRQALDKERVGLNHIRSLQDVSLLPFTTKDDIRNNYPYGLFSVPLKKIVRLHASSGTTGKPTVVGYTKQDIELWADMVTRLAVAAGAREEDVAQVAFGYGLFTGAFGLHYGLERLGATIVPASTGNTERQIMMMQDFGTTILVSTPSYSLYLAETAHTMGIDIRSLTVRLGLFGAEGCSEEMRQVIERIWGISAVENYGMSELIGPGVSGECECKAGLHINEDHFYPEIIDPLTGTPLPYGEMGELVITTMTKEGFPLLRYRTRDITSLNPEPCQCGRTLVRMTKVQGRTDDMLKIRGVNVFPSQIESVLVGIREIGPHYNIIVRKKGYLDDMEVMVELADETLLEDFRKLEGLQDVIRHKLRVILALDATVKLVQPRTIARSEGKAKRIIDLRNKKE
>NZ_CP036259.1|WP_144351063.1|3111717_3113298_-|sodium:solute-symporter-family-protein
MDKQLLYSMLVVYLGITVLLGYLGYRHTKSAKDYMIAGGNVHPVLMALAYGSTFISTSAIVGFGGAAGVYGMSLLWLTAFNIFIGVFVAFVFFGVRTRQIAHQLQVKTFPEFLGARFDSLFIRRFSAGMISLTMPLYAAAVMIGGARYMEEALNMSYTLALTIFALIVLAYVFFGGLRGVIYTDAMQGLIMFAGMAALIVLTYSLLGGVTPAHSKLEALKQLVPAGLAAKGHLGWTAMPAFGSEIWWFVISTLILGVGIGVLAQPQLAVRFMTVASSQDIYKGLSIGALFILFMTGVAFTVGALSNVYFMEHGGTLALAATAVGGAVPNVDKIIPLFITQAMPEWLKYLFLFTLLSAAMSTLSGQFHIISTSISYDLNPKQARSDKKTLLLARLGTLFGFVLTIALALKLPFGVIAVATALFFGLCTSAFLPMYTAALYWPKVTPAGAIASMVIASAIYLCLVLFVHEKEATIFGICFKLFGVNTLALAPWTYIDPLVVTLPISALVLVTASLLTQPVPQTVTEGR
>NZ_CP036259.1|WP_144351064.1|3113914_3114385_-|DoxX-family-membrane-protein
MKQSLRLFARFLSRYRDLALLIFRLGLGGMFMWHGWPKIIGGPEKWAGLGKAVGTFGIEFAPGFWGFMASFAEFGGGLLFAVGLFYRPACFLLFSNMMVAFISQMMDGKGLQKASQSLEDGLSFFAAAFIGPGRYSLDYLLGIEESSEPQNRMGRR
>NZ_CP036259.1|WP_144351065.1|3114553_3115507_+|D-2-hydroxyacid-dehydrogenase
MKTVFLNLAKLDFDSKLDFSRLTQQTTVTKYAASSDKEILDRIKDQNIVITKELPVGKDLIAQFPPSVRLICEAGTGYNNIDIAAAREKNITVCNIPGYSTEAVAQLAITFILSLSASLTQQQIMLKQNNYDNFTKHLLVPHGEIQNKTLGIIGAGSIGRQVITIARALGMNALVFNRTPKTWDDPKIKSVSLTELLAHSDFISLHCPLTPDTKHLINKETLSLVKSSAFIINTSRGALIQESDLIAALQAGTIAGAALDVQDPEPPALDNPLLTMNNVILTPHIGWKPLEARQRLINLIAGNIEAFILEKPINVVN
>NZ_CP036259.1|WP_144351066.1|3115713_3117630_+|sigma-54-interacting-transcriptional-regulator
MIKISNVKLQNLINSAFLQEFQDNFALSVGVASLIEDNQGQALTCPSCFSTFCKEIIRTSPRGLQRCLADDMRGAALAVRTGKPAVYQCHAGLIDFAAPILLHGQVLGTIFGGQVLTTPPTQAACHKAAKELGVDAAKYLAAIKEIPVVTTEKIHAAAKVLFSVANTLSQNAYQTLRLKETTREIVLSYNRLENIFNTMSDGVIIIDNNGIVKQVNVIAEEIFDRPGPELLNKSVKELMGSEPPFIENIYKLQAAYTDFEIFIDASLGRLHCLSSGRPIVDDEGELSGAVILLRPMKIVHNLVNRLSGAQATFRFGNIIGQGPAIRKTVQLATQAAAGVSNVLIEGESGTGKEVFAQAIHNQSARRKGPFVAVNCGAIPRELMISELFGYTEGAFTGARRGGRPGKFEFASGGTIFLDEIGDTPLELQVALLRVIQERKITRMGDNKVIPVDLRIICATNKNLAQEVEKGNFRQDLYYRLNVISLKIPPLRERQEDIPLIFKYMLNTMGREWGKAIKKVDPAVITLLQQYHWPGNIRELQNIVERVISIAEEDIIKPEHLPEHLVTPAGLPAFYLTSPSKQDDICARERIKQDLNEKERQQIVDYLLSASGNISHAAKQMGIARSTLYRKMRYYNLSN
>NZ_CP036259.1|WP_144351067.1|3117700_3118756_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKAAVWYGQKDVRVMDVPEPPSPPAGWVKVKVQWCGICGSDLHEYLAGPIFIPVDKPHALTGSTAPIILGHEFSGDVVEVGPGVTNVAIGDRVAPDACQVCWECPRCREHRYSLCEKLAFTGLMTDGAFAEYVNVPAYTIYKIPADMSYEAAALIEPLAVGMHAVRRAPLVQGDTAVIMGAGTIGLATLMCAKAAGASKVYTVEVARARKEYALKAGATAVLDPTEVDVIARVKELTNGGADVVFECVGSDKTAPVALELARSAGKVVIVGIFEKASVLNFNALSFTEREVMGSLAYYGEFAPAIQLVADGRINVEPLITGKISLNDIVEKGFEELVHRKEQNIKVIVKPF
>NZ_CP036259.1|WP_144351068.1|3119122_3120007_-|radical-SAM-protein
MNKIAFYAPGVRHYDNGLYQNSAHSFVNISITGSACQCRCEHCRGQLLNTMVAAAEPELLVKLAADLRRRGCRGVLISGGACRDGSVPLQRFAGALQEVAALGLAVVVHPGLLTNELAQVLAQAAVTRVALDLIGDSDTIRKVYHLTRTPEDYQNSLRAARLAGLKASPHIVIGLHYGEIRGEYEALKMVAAEGAESLVLVLLNPLRNTPMGAVVPPPAESVAKIFKTARELLPAIPLALGCARPPGLYARTIERLAVEAGFDAIAYPARETVDYVYSLGYTVTYQETCCGLLA
>NZ_CP036259.1|WP_144351069.1|3119999_3121073_-|radical-SAM-protein
MDNIGRQESPDYVQTSLAGAMALGLEPGSFYRNAYPGSLNLLMTYQDGCRANCSYCGLARERWAEPDEHTFIRVKWPVYELADIIGILARPPQAAAAKVQKLGRICISMITHPRAAADCIDIVRQLSAASPLPVSVLASPTILPAGGAFFQAVKAAGADRVGIAVDAATAALFAGLRGPAVGGPHRWETYWEAVEQAVKVFGSGHVSVHLIVGLGETEQAMVQAIDRANQYGAQAHLFSFCPEPGSRLGGRKPPAYGQYRRIQLAAYLLNNRHSTIDAFAFNGHGKIVGYGSRLQELLGDDLAAGEPFRTSGCPNREGCVACNRPYGNERPGPDLRNYPFSPDSSDIDIIKGQIWDE
>NZ_CP036259.1|WP_170233288.1|3121116_3122199_-|NAD(P)/FAD-dependent-oxidoreductase
MKTTAEHYDVAVVGAGPAGCIAAKRLGQAGLKVVLVEQRQVIGSPVQCAEFVPLAISRHTAVRAGDIAQPVRGLKTFINGKLASTLRAPGYVLNRGLWAEYQARLAAAAGAAIMTATRVSGIDGKQLTLVNGAHSRALRADFILGCDGPCSVVSKKLANEAQPMCFALQYEKMLVKSLEYAEIYFDPAYYGGYAWVFPKGKTANVGVALHAAYKDKLKAALADFCRQLIGGGRIQAGAPAGATGGLIPAGGLVKNPANDHMLVAGDAAGCTHPITGAGIMNAVVSGDLAARSVLLQVSSNGSEPVARNYTRTLLAEYGTQFAIASERLLSRNQRWTDQPEEFSALIRSSWIAFPEYYRQQ
>NZ_CP036259.1|WP_144351071.1|3122182_3123313_-|lipoate--protein-ligase-family-protein
MPSVDNSAAFRVLDSAPCSAAEHMALDKVIISAHSQGHIPNTLRFLQFKPCVLVGAFQNTLLEVNVPYCQHHGIAINRRLTGGGSLYWGRREIGWELYAGKNTPGIPRQVEGLYRLLCEAMARGLRTLGLAAAYRPVNDIEIQGRKIAGTGGTELADSFVFQCSLLVDFDVEQMLRVLRFPLEKLSDKAVKSMRERVTSLKEQLGYVPAAGLIKHAIITGLQKTLGYEFTGGGLTALETGLLSEYLPYFQSEAWVYGSAGRVVNTVDCLANYKAPGGLIRIQMRLDEGIGVIKYLLISGDFFAYPARVINDLETALKNTPIDRLRIADLITNFFLANQAEIPGVLPEHFVAAILLAVEKAREVRLAGPEVCCENNS

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Crispr_ID: NZ_CP036259_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_12

3413209-3413303

Orphan

Consensus_repeat	Method
GATGGATACACAGCTTAAGTACCTTATACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP036259_12

>merge|NZ_CP036259|12|3413209-3413303|CRISPRCasFinder
GATGGATACACAGCTTAAGTACCTTATACCGGGTATGCCAAACGGGCGCAGACGGCACGGGCAACGATGGATACACAGCTTAAGTACCTTATACC

>NZ_CP036259|12|12|3413209-3413303|CRISPRCasFinder
GATGGATACACAGCTTAAGTACCTTATACC	GGGTATGCCAAACGGGCGCAGACGGCACGGGCAAC
GATGGATACACAGCTTAAGTACCTTATACC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144351292.1\|3406666_3407671_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380548
NZ_CP036259.1\|WP_170233403.1\|3409831_3410821_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380548
NZ_CP036259.1\|WP_144351306.1\|3425305_3426271_-\|hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240650
NZ_CP036259.1\|WP_144351304.1\|3422065_3423316_-\|C4-dicarboxylate-transporter-DcuC	unknown	unknown	gnl\|CDD\|225611
NZ_CP036259.1\|WP_144351289.1\|3400113_3401181_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP036259.1\|WP_144351302.1\|3419856_3420444_-\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|224527
NZ_CP036259.1\|WP_170233303.1\|3413460_3413874_+\|M20/M25/M40-family-metallo-hydrolase	unknown	unknown	gnl\|CDD\|349936
NZ_CP036259.1\|WP_144351290.1\|3401164_3401995_-\|molybdate-ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223629
NZ_CP036259.1\|WP_144351301.1\|3416690_3417686_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
NZ_CP036259.1\|WP_144351291.1\|3402082_3403111_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270226
NZ_CP036259.1\|WP_144351305.1\|3423595_3424921_-\|GTP-cyclohydrolase	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351299.1\|3415067_3415850_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
NZ_CP036259.1\|WP_144351303.1\|3420611_3421919_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|349915
NZ_CP036259.1\|WP_144351298.1\|3414134_3414962_-\|epoxyqueuosine-reductase	unknown	unknown	gnl\|CDD\|224516
NZ_CP036259.1\|WP_144351294.1\|3408865_3409747_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226605
NZ_CP036259.1\|WP_144351288.1\|3398949_3399960_-\|DUF3231-family-protein	unknown	unknown	gnl\|CDD\|371599
NZ_CP036259.1\|WP_144351287.1\|3398459_3398945_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351300.1\|3415833_3416667_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224041
NZ_CP036259.1\|WP_144351296.1\|3411440_3411968_-\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238245
NZ_CP036259.1\|WP_144351293.1\|3408073_3408865_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224026

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144351292.1\|3406666_3407671_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380548	cd06325, PBP1_ABC_unchar_transporter, type 1 periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally.	2.62812e-104
NZ_CP036259.1\|WP_170233403.1\|3409831_3410821_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380548	cd06325, PBP1_ABC_unchar_transporter, type 1 periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally.	4.66542e-109
NZ_CP036259.1\|WP_144351306.1\|3425305_3426271_-\|hydroxyacid-dehydrogenase	gnl\|CDD\|240650	cd12173, PGDH_4, Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains. Phosphoglycerate dehydrogenases (PGDHs) catalyze the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDHs come in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases. PGDH in E. coli and Mycobacterium tuberculosis form tetramers, with subunits containing a Rossmann-fold NAD binding domain. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	1.85066e-125
NZ_CP036259.1\|WP_144351304.1\|3422065_3423316_-\|C4-dicarboxylate-transporter-DcuC	gnl\|CDD\|225611	COG3069, DcuC, C4-dicarboxylate transporter [Energy production and conversion].	7.2685e-60
NZ_CP036259.1\|WP_144351289.1\|3400113_3401181_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	2.06269e-141
NZ_CP036259.1\|WP_144351302.1\|3419856_3420444_-\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	5.38707e-44
NZ_CP036259.1\|WP_170233303.1\|3413460_3413874_+\|M20/M25/M40-family-metallo-hydrolase	gnl\|CDD\|349936	cd08014, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of uncharacterized bacterial proteins predicted as putative amidohydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	1.48057e-40
NZ_CP036259.1\|WP_144351290.1\|3401164_3401995_-\|molybdate-ABC-transporter-permease-subunit	gnl\|CDD\|223629	COG0555, CysU, ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones].	1.63465e-71
NZ_CP036259.1\|WP_144351301.1\|3416690_3417686_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	2.53136e-33
NZ_CP036259.1\|WP_144351291.1\|3402082_3403111_-\|extracellular-solute-binding-protein	gnl\|CDD\|270226	cd01005, PBP2_CysP, Substrate binding domain of an active sulfate transporter, a member of the type 2 periplasmic binding fold superfamily. This family contains sulfate binding domain of CysP proteins that serve as initial receptors in the ABC transport of sulfate and thiosulfate in eubacteria. After binding the ligand, CysP interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The CysP proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.46361e-80
NZ_CP036259.1\|WP_144351299.1\|3415067_3415850_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.34417e-70
NZ_CP036259.1\|WP_144351303.1\|3420611_3421919_-\|amidohydrolase	gnl\|CDD\|349915	cd05665, M20_Acy1_IAAspH, M20 Peptidases aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase. Peptidase M20 family, bacterial and archaeal aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase (IAA-Asp hydrolase; IAAspH; IAAH; IAA amidohydrolase; EC 3.5.1.-) subfamily. IAAspH hydrolyzes indole-3-acetyl-N-aspartic acid (IAA or auxin) to indole-3-acetic acid. Genes encoding IAA-amidohydrolases were first cloned from Arabidopsis; ILR1, IAR3, ILL1 and ILL2 encode active IAA- amino acid hydrolases, and three additional amidohydrolase-like genes (ILL3, ILL5, ILL6) have been isolated. In higher plants, the growth regulator indole-3-acetic acid (IAA or auxin) is found both free and conjugated via amide bonding to a variety of amino acids and peptides, and via an ester linkage to carbohydrates. IAA-Asp conjugates are involved in homeostatic control, protection, storing and subsequent use of free IAA. IAA-Asp is also found in some plants as a unique intermediate for entering into IAA non-decarboxylative oxidative pathway. IAA amidohydrolase cleaves the amide bond between the auxin and the conjugated amino acid. Enterobacter agglomerans IAAspH has very strong enzyme activity and substrate specificity towards IAA-Asp, although its substrate affinity is weaker compared to Arabidopsis enzymes of the ILR1 gene family. Enhanced IAA-hydrolase activity has been observed during clubroot disease in Chinese cabbage.	0
NZ_CP036259.1\|WP_144351298.1\|3414134_3414962_-\|epoxyqueuosine-reductase	gnl\|CDD\|224516	COG1600, COG1600, Uncharacterized Fe-S protein [Energy production and conversion].	1.78226e-31
NZ_CP036259.1\|WP_144351294.1\|3408865_3409747_-\|ABC-transporter-permease	gnl\|CDD\|226605	COG4120, COG4120, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.36297e-103
NZ_CP036259.1\|WP_144351288.1\|3398949_3399960_-\|DUF3231-family-protein	gnl\|CDD\|371599	pfam11553, DUF3231, Protein of unknown function (DUF3231). This bacterial family of proteins has no known function.	6.21358e-56
NZ_CP036259.1\|WP_144351300.1\|3415833_3416667_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	2.51409e-130
NZ_CP036259.1\|WP_144351296.1\|3411440_3411968_-\|isochorismatase-family-protein	gnl\|CDD\|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	8.27372e-33
NZ_CP036259.1\|WP_144351293.1\|3408073_3408865_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224026	COG1101, PhnK, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	9.30321e-120

>NZ_CP036259.1|WP_144351296.1|3411440_3411968_-|isochorismatase-family-protein
MKNILLVIDYQNDFVDGALGFSQAAELETAIVAKIEHYKRNGDPVAFTFDTHQPDYLATQEGKKLPVLHCLQYTPGWQLYGQVASLCSAGDLRFEKGAFGSMELVAYLRGQGFERVELVGVVSHICVLANAVLAKAALPEAEIVIDAACTASFDERLHQAALDVMAGLQMTVVNR
>NZ_CP036259.1|WP_170233403.1|3409831_3410821_-|ABC-transporter-substrate-binding-protein
MHLKKMIALGLGAVLVAGVIAGCGGEKKKAGAEAGKVYRIGVLQLVQHGALDAANQGFVDGLAARGYKDGETIHLDQQNAQGDQSNLKTISQRFVNNKVDLIYAIATPAAQTVANETKTIPVVGSAITDYEAAKLVRSNDKPGGNVTGTTDYIPPKQQIDLALTLIPQAKTVGALYTASEANSQVQVKAMKEYAAEQGLTVVEASVANVNDIQQAVQSFVGKVDFIYCPTDNTIASAMANIAKIAVPAKLPVFAGDETMVRTGGTAGVSVNFYQLGFQSGEMAADILAGKASPAAMPVAAQKEAKVIINKEAAAAIGLTIPDELLKAAE
>NZ_CP036259.1|WP_144351294.1|3408865_3409747_-|ABC-transporter-permease
MNDLVISTIAQGLLWSVMAIGVYLTFRILHIADLSVEGTFPLGAAVAAVLLEGQHSPAAAILAAGIAGMLAGAATGLLHTKLKIPALLAGILTMIALYSVNLRVMGKANVSLLNTDTVYTSLEFLHLSPNMTTFVVGLIAAVVCPALLYWFFGTEIGLALRATGNNPQMIRAMGVNTDNMILLGLVLSNGVVAVSGALIAQSNGFADVGMGVGTIVIGLASVIIGEVLFGSRSVKNALISVVLGSIVYRIVIAVVLYLGMPPNDLKLFTALLVAIALSLPLVKTRLDSRKAGI
>NZ_CP036259.1|WP_144351293.1|3408073_3408865_-|ATP-binding-cassette-domain-containing-protein
MLKIEGISKTFFAGTVNEKLALRNVSLEMKTGDFITVIGGNGAGKSTLLNSIAGVFKVDCGRIYLDDIDVTGMSEHKRAAYIGRVFQDPMLGTAADMMVEENLAIAARRGKKLGLRWSFRQDEFAEFKAKLAKLDLGLEERLKNRIGTLSGGQRQAITLLMATLRKPKLLLLDEHTAALDPKTAEKVLNLTQNIVAENGLTTLMITHNMRDALRFGNRLLMLDDGKILLDIHGAEKAKMTVHDLLDAFEHSGGEEVSDRMLLS
>NZ_CP036259.1|WP_144351292.1|3406666_3407671_-|ABC-transporter-substrate-binding-protein
MLKTLHLKKMIALGLGAVLVAGVIAGCGGEKKEAGAEAGKVYRIGVLQLVQHGALDAANQGFVDALAARGYKNGENITIDQQNAQGDQSNLKTISQRFVNNKVDLIYAIATPAAQTVANETKTIPVVGSAITDYEAAKLVKANDKPGGNVTGTTDYLPPKQQIDLALKLIPQAKTVGALYTASEANSQVQVKAMKEYAAEQGLTVVEAAVTNVNDIQQAVQSFVGKVDFIYCPTDNIIASAMANIAKIAVPAKLPVFIGDEAPVKTGGATAGVSVNFYQLGFQSGEMAADILAGKASPAAMPVAAQKEAKVIINKEAAAAIGLTIPDELLEAAE
>NZ_CP036259.1|WP_144351291.1|3402082_3403111_-|extracellular-solute-binding-protein
MKRKLIVFGALLLGLGLFVVGCGSDKKEVAKEVKTVEIGISSCCVSEDVTTKEIIPAFKKYYKEKFGEEVEVKPSFAGSGTLTNQIVGGTPVQVAVLSNESYALKLKAEGLTTSDWKALPNKGVVATSTIIMLVREGNPKGIQSYADLAKPGVKVIHSNPATSGGASWAIYSFYGSVLKETETKTGQKDEAAAYELLKKIEDNVISMPESAKQAAAQFDAGQGDALVTYEQEGLLELEKGKKYQVIVPNSTILTDWTVVQVDKNIKPEQKQVIDEFVKFLFSDEAQNAYAQYGFRSYKPEINAKLASKYANIELPFTLDYLGGSTEAKKTIIDGLWKKTQQK
>NZ_CP036259.1|WP_144351290.1|3401164_3401995_-|molybdate-ABC-transporter-permease-subunit
MMKLEQLLARTLVGIILLIFTILILFPLGQLFTYASKAGLGIFVDRLLSPEALAAIWLTIKIGLASTAVNVVIGTAVAFVLHRVDLPFKNVIDALVDIPLAIPTVVIGFALLLLYGPAGWLGRFIDPETIQILFSFPGILLAHIFFTFPFMVRAVGTSLSGFDQNYERAAKTLGASRLQTLVYITLPGIKTGLIAGSVLTFAKSVGEFGATLMVSGNLIGRTQTGPLYIFSRFNTGDIEGASAIALILAVFSFIILFCLRWLTSDKREVIRIDTIH
>NZ_CP036259.1|WP_144351289.1|3400113_3401181_-|ATP-binding-cassette-domain-containing-protein
MTRSIDVRDLTMKYGQATALDHVSLLVEQGEFLAILGPSGCGKSTLLNLIAGLQSAVQGEIYVGEQRIDGLPPQKRGIGFVFQNYALFPNMTVGENVAFGLKIRKAGGAVIDSRVAELLHIVNLQDQAHKKPNQLSGGQQQRVALARALAPKPDILLLDEPLSALDVKIRQHLRNEIKSLQRKLGITTVIVTHDQEEAFELGDRVAVMEQGKIVQIGDPETIYQAPATEFVACFVGNINRLAGGIKNSQVHVAGLVLPLPAQLRDLPAGTAVIALVRPENLSVELADDGAEGAAGATCGTISHTVFLGPLMQLHIRLDEGQTVMAIVPQAKARQENLTAGRRVALRADLYQIVRA
>NZ_CP036259.1|WP_144351288.1|3398949_3399960_-|DUF3231-family-protein
MSNHNTIRLTAAEAASLWSQYQADTMVSCVLTHFLNTIQDAEIRPLIEYAMQESQKHIRTIKEIFVQDGYPVPFGFSPAEDVVTTAPRLFTDVFILMYLRHMSIIGITGAGLTIGTAARSDVSTLFMEVIAGAVELHDRARQLLLKKGLYVRTPSISAPLKAEYIQKQSFLTGFLGEKRTLTAIEITHLIQNIKTNEMGKAMSIAFAQCARNNDTRNFLWRAKQISEKHIAIFTTTLTQDDIPVPMPSDPSVSGSTTAPFSDKLMIFHICTMNAAGIGNYAVGAAASQRRDLVVLYGRLIAAIGLLAEDGVQIMIDNNWLEQPPMAEDRAALVGNH
>NZ_CP036259.1|WP_144351287.1|3398459_3398945_-|hypothetical-protein
MANQIEKVLWSIAFPGFGQILNGKLVKGVIFLGLEFLINVKANLNQAIVFSFIGDIDQAILITNYQWVMFYPCIYSFAIWDAFRDAGGGKAAYAYLPCVFSAYFGTLGVVYSTVVVVFGTLLGPILLGLIGLAGGAVLGGIVKTLINSRTNSKLQKITTAE
>NZ_CP036259.1|WP_170233303.1|3413460_3413874_+|M20/M25/M40-family-metallo-hydrolase
MLGGTLRCFKTEIAEQAGELIEQTVKAISSLHGAQYQFSFARGLVPLINDATAVDLLTSAAREIAGEHSVVPVPQVLLGEDFSLYCQQVPAAFFVLGTGFAGQKNYQLHHSKFNLNEAALVVGASVLANAALAALRK
>NZ_CP036259.1|WP_144351298.1|3414134_3414962_-|epoxyqueuosine-reductase
MAITKLQISKYARKLGANLIGFAPASRWDEYNEVEAAYRPAAIWPETNTVIVLGVPVLLPIIETTPSINYVELYDTTNKLLDQIAYRLAVYLTEKGHGSIFMPRDAYGDIQVLVNKPVAAFSHVFAGKYAGLGTIGYSHVLLNRQYGPRVRYVSVFTRLKIAPDDVLATDLCTKCRVCQRLCPTQAFTSRDDQLIALMDKHACARYHAQLRQEHRYPCGVCAKVCPVGEDRQVFNSTDIGLYLQEKETISKNPEDPRYKRWVHMRRHGSDGERLF
>NZ_CP036259.1|WP_144351299.1|3415067_3415850_-|ABC-transporter-permease-subunit
MKKLADLFSSSFEKTVGLILFLALWEIAPQAGWVNSTYLSPPSAVYKAMIGLFHSGELAKHLLISLQRVLIGMAVSVIVGTIFGLFIGYFKRIERFLDALFQSFRQMSAFALFPVFILLFGVGELSKTIIIFWASLWPVLLNTSHGVKHVDRLVVQSVKSMGASQGFIFLKVILPAAAPDIFTGIRLGGSYCVMALVAAEMIGATAGLGYLIMYSQETFNIPEMYAGIVSLAIMGLGINYVLKLIEKFFTNWKQDVSVGE
>NZ_CP036259.1|WP_144351300.1|3415833_3416667_-|ATP-binding-cassette-domain-containing-protein
MTKIQASQVCREFQVKSNSGKKEKLVVLDDFNLQVREGEFLSILGPSGCGKSTFLNILAGLDQHDGGEILVDGQPVKDRSFDRGLVFQGYALLPWRTVLENLEVGLEIRNIGKKERRAIARHYLALVGLSAFANQYPHQLSGGMRQRVAIARVLAYQPNLLLMDEPFAALDAQTRETLQIELIKIWEADKKTIVFITHSIDEAILLSDRVAVMTARPGTIKEIIEVPLPRPRTEEIRNSAEFARIRQYAWELIKDEVSKAQRLQTGSKEGEDHEKTG
>NZ_CP036259.1|WP_144351301.1|3416690_3417686_-|ABC-transporter-substrate-binding-protein
MGKIKQMAVLGVIAIILSVLIAGCGGDTAKQTAQKGEKQVVEFKYPELVYYDFIYLADELGYFKDAGVRPKYIGKLATGQVIPSLVNGSIDIATRHTPVVIAAVASGADIKIFAAGSQSTKQWPHMKYFVKADSEIKSIKDFAGKTIGLNSFGACSEYVTKKYLQENGADPASINFKTAPEDQQEVPLLRGDTDIAIIHPPASGRTAANTAQFTLLFSDYDIDQGLSGMCPYSVNGKFAREHPEAVKELTEILIKTAKWNNEHQEEARAIMAKRFNIDVNQAEMYEFYPDQLVPEAGVKYWIDRLVAANKLAPGQVTPEQIYTNDFNPAKK
>NZ_CP036259.1|WP_144351302.1|3419856_3420444_-|TIGR00730-family-Rossman-fold-protein
MSKVICVYSSSSWAIDPVYFDAATALGREIAAKGHLFLFGGGLTGLMGACARSVHQHHGHVIGIIPAALNVKGIVYDRCDELVVTKGLRERKAAMDERSDAFIALPGGYGTLEEILEIITLKQLQYHNKPVAILNINHFYDNLLEQFETIIAQQFAKTECQELYFVTGDISSALDYIDSYEPPVFAPRWLTAVED
>NZ_CP036259.1|WP_144351303.1|3420611_3421919_-|amidohydrolase
MNTDILELVKAKQEQLVNCRRDLHKHAETAWTEFRTASIVAETLTRLGYQVAVGEEVIDAEVMMGVPSPQELINQQERAIAQGADPNWVGRMQGGKTGVMGVLHFVQPGPVVAFRFDMDANEVVEATLAEHRPWRDGFASVNAGAMHACGHDGHTAIGLTLAEILAEVKNELAGTVKLIFQPAEEGVRGAKAMVARGIVDDVDFFVGLHLGIGLQQKGTMTCNTVGFLATTKLDAVYTGVPAHAGAAPETGHNALLAAATAALNLHAISRHSQGASRINVGVLQAGTGRNVIPDKAVLKLETRGTTSEINDYMYQRALRILAAAAAMYEVKLDLSPMGGAANCDNNPILVRRLRQVAEKSNLFASILPAGNIGGSEDCTYFMERVQQQGGQAAYLMIGTELAAGHHDSRFDFDEESLVSATALLGQAAVELLRKQ
>NZ_CP036259.1|WP_144351304.1|3422065_3423316_-|C4-dicarboxylate-transporter-DcuC
MMLTIGVILVIITIYFLVKRYDARLVLLVSGVLMACVAGTPMAALNAFAKDMTNAGLIQAVCSVMGFAMVMRFTECDKHLINLMASGLGKVRPLLIPGVVVATYAVNVALPSAAGTAAAAGAIFVPLMMSAGVHPAMAAAAVKCGTYGSMLNPGLAHNPVVAKIAGIGVMEVIAFQFKANIASLIVAAILITAIAYYKKEHKGYHAEGLEVDNSFKVNLLYALMPMFPILLLLLGATLVPSLKTDVPQAMIIGSALSLLVTRKNPVGLSNAFFDGMGKAYGEIIGIIIAAGVFVSGLTSMGLVKAFIDAMLNNPAIVKVCAAVGPFLLGFITGSGDAATMAFNQAVTPHAADFGMEIKQMGSMATLGGTLGRTMSPIAGATIIVAGIAGVNPMEVTKRNWLPVVGAMIIGMALLMY
>NZ_CP036259.1|WP_144351305.1|3423595_3424921_-|GTP-cyclohydrolase
MEKIRLAIVGPSDSVSLAYAVAAERNDILAPQVIVYQDAAQVPEIMRARCPEFDMWLFSGIVPYHYALSVATHKPVFYIPHTGCSLYRALFEITYIKKLKLHRISFDTYNQADVEETFKDINLPLPTIYVKPFADVVSAKDFANHHYELWQAGKIDIAVTCFLATYERLKELGVPVIRVWTTRSNIRTTLDVAINSCLAQRFKGTQLAIQEIAIDEYDNIVRASSSYNVKRMEMCLYKILIDYAEMLKGSLVSRGDGQYTLYSTRGILEDSTNELTIIPILEEISCQVKAAVSGGIGFGVTAYDAEQNAFRALGMAQQKGKGLWLAVNDDREVIGPLSSAVHLKYSVQADAASCKRVADQLNLSVTTVNRLLAVIDKLDKDTIGAEELGVYLTITSRSARRILTILVENGLAEFAGEEMIAKGRPRKLYKINVQLLLAHCT
>NZ_CP036259.1|WP_144351306.1|3425305_3426271_-|hydroxyacid-dehydrogenase
MDIIITEAMGAPGLEVLRKSGYSVQYDPSLWSDVERLKAAVAKAKALIVRNQTKVNKELLYDLKNIKIIGRLGVGLDNIDLGTTAAHGIPVVTAKNANAVSVAEYVLAAILTISRPLLAASADVKAGGWNRKCFGGTEIQGKTLGLIGIGEIGHRTGIKAKALGLNVIGCDPRLTSYDIAPDLTGITLVSEEEVLRQSDFVSLHVPLLPSTSNLIDRAALARMKSTAYVINTSRGGVVNEEELYEALTHNQIAGAVLDVLHTEPPGAEHPLFSLPNCLMTPHVAGAAQEALNRTSLLIAAAVLLELGGDVSKYRVDVNSWL

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Crispr_ID: NZ_CP036259_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_13

3887444-3888586

TypeI

I-C

Consensus_repeat	Method
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	PILER-CR
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CRISPRCasFinder
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CRT

17 spacers

DEDDh,cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP036259_13

>merge|NZ_CP036259|13|3887444-3888586|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGACAAAATTACCCGGAAAACTGTGTCCATAACCTATGTTTCAATCCACGCGCCCGCAAGGAGCGCGACGGTCTAAAGGTGAGTGTAGAGGCCGTAAGACAGGTTTCAATCCACGCGCCCGCAAGGAGCGCGACTATAGCACTAATTTAACCACAGGTAAAGTCATCGGTTTCAATCCACGCGCCCGCAAGGAGCGCGACCTAATAACAATGGAGCAATTGCAACAACTAGAAGTTTCAATCCACGCGCCCGCAAGGAGCGCGACGCGTATACAATTTAATATCATCACGATAAGCAGGGTTTCAATCCACGCGCCCGCAAGGAGCGCGACAGATTCCAGGGCCATCTTATCTCGGGATGCAAACGTTTCAATCCACGCGCCCGCAAGGAGCGCGACATGGTCGGAGCAAAAGAAGATGAGGTTACCAAAGTTTCAATCCACGCGCCCGCAAGGAGCGCGACAAAAGAACTATTGCCCCAAAAACCCGCAAAAAGGTTTCAATCCACGCGCCCGCAAGGAGCGCGACAAAATATTTCATTGCGGCTCCGTTACTGAAATGTTTCAATCCACGCGCCCGCAAGGAGCGCGACGAAAGCCCGAAAGGAAGCGCCCAAGAACCCTATGGTTTCAATCCACGCGCCCGCAAGGAGCGCGACGCCCTTGTTACTCCGGTATATCGCCATCTAGCTTGTTTCAATCCACGCGCCCGCAAGGAGCGCGACCGTCCACGCAGCGGATCTTCCCAATCCGGGCATGTTTCAATCCACGCGCCCGCAAGGAGCGCGACCCATGTCGTACCCTTATAGATCAGCGCCACGTTGGTTTCAATCCACGCGCCCGCAAGGAGCGCGACCTTTAAAAAAATGAACTATGTTACAGGCGGATTTGTTTCAATCCACGCGCCCGCAAGGAGCGCGACTTAACCCAATAGCATCAGCTAATTGTGCTATAGGTTTCAATCCACGCGCCCGCAAGGAGCGCGACAGATACCCGCCATGCCGGCAGTTGCCTTGGCAAGTTTCAATCCACGCGCCCGCAAGGAGCGCGACTCTAGTTTAAGGCACTGTAATTCTGTTTTTAGCGTTTCAATCCACGCGCCCGCAAGGAGCGCGAC

>NZ_CP036259|13|6|3887444-3888586|PILER-CR
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAATTACCCGGAAAACTGTGTCCATAACCTAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GGTCTAAAGGTGAGTGTAGAGGCCGTAAGACAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TATAGCACTAATTTAACCACAGGTAAAGTCATCG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CTAATAACAATGGAGCAATTGCAACAACTAGAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GCGTATACAATTTAATATCATCACGATAAGCAGG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AGATTCCAGGGCCATCTTATCTCGGGATGCAAAC
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	ATGGTCGGAGCAAAAGAAGATGAGGTTACCAAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAAGAACTATTGCCCCAAAAACCCGCAAAAAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAATATTTCATTGCGGCTCCGTTACTGAAAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GAAAGCCCGAAAGGAAGCGCCCAAGAACCCTATG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GCCCTTGTTACTCCGGTATATCGCCATCTAGCTT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CGTCCACGCAGCGGATCTTCCCAATCCGGGCAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CCATGTCGTACCCTTATAGATCAGCGCCACGTTG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CTTTAAAAAAATGAACTATGTTACAGGCGGATTT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TTAACCCAATAGCATCAGCTAATTGTGCTATAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AGATACCCGCCATGCCGGCAGTTGCCTTGGCAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TCTAGTTTAAGGCACTGTAATTCTGTTTTTAGC
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC

>NZ_CP036259|13|13|3887444-3888586|CRISPRCasFinder
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAATTACCCGGAAAACTGTGTCCATAACCTAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GGTCTAAAGGTGAGTGTAGAGGCCGTAAGACAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TATAGCACTAATTTAACCACAGGTAAAGTCATCG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CTAATAACAATGGAGCAATTGCAACAACTAGAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GCGTATACAATTTAATATCATCACGATAAGCAGG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AGATTCCAGGGCCATCTTATCTCGGGATGCAAAC
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	ATGGTCGGAGCAAAAGAAGATGAGGTTACCAAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAAGAACTATTGCCCCAAAAACCCGCAAAAAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAATATTTCATTGCGGCTCCGTTACTGAAAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GAAAGCCCGAAAGGAAGCGCCCAAGAACCCTATG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GCCCTTGTTACTCCGGTATATCGCCATCTAGCTT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CGTCCACGCAGCGGATCTTCCCAATCCGGGCAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CCATGTCGTACCCTTATAGATCAGCGCCACGTTG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CTTTAAAAAAATGAACTATGTTACAGGCGGATTT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TTAACCCAATAGCATCAGCTAATTGTGCTATAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AGATACCCGCCATGCCGGCAGTTGCCTTGGCAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TCTAGTTTAAGGCACTGTAATTCTGTTTTTAGC
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC

>NZ_CP036259|13|7|3887444-3888586|CRT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAATTACCCGGAAAACTGTGTCCATAACCTAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GGTCTAAAGGTGAGTGTAGAGGCCGTAAGACAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TATAGCACTAATTTAACCACAGGTAAAGTCATCG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CTAATAACAATGGAGCAATTGCAACAACTAGAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GCGTATACAATTTAATATCATCACGATAAGCAGG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AGATTCCAGGGCCATCTTATCTCGGGATGCAAAC
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	ATGGTCGGAGCAAAAGAAGATGAGGTTACCAAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAAGAACTATTGCCCCAAAAACCCGCAAAAAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AAAATATTTCATTGCGGCTCCGTTACTGAAAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GAAAGCCCGAAAGGAAGCGCCCAAGAACCCTATG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	GCCCTTGTTACTCCGGTATATCGCCATCTAGCTT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CGTCCACGCAGCGGATCTTCCCAATCCGGGCAT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CCATGTCGTACCCTTATAGATCAGCGCCACGTTG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	CTTTAAAAAAATGAACTATGTTACAGGCGGATTT
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TTAACCCAATAGCATCAGCTAATTGTGCTATAG
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	AGATACCCGCCATGCCGGCAGTTGCCTTGGCAA
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC	TCTAGTTTAAGGCACTGTAATTCTGTTTTTAGC
GTTTCAATCCACGCGCCCGCAAGGAGCGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144351694.1\|3889052_3890084_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NZ_CP036259.1\|WP_144351695.1\|3890080_3890776_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|273040
NZ_CP036259.1\|WP_144351690.1\|3885628_3886180_-\|3'-5'-exoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NZ_CP036259.1\|WP_144351686.1\|3880586_3881957_-\|uroporphyrinogen-decarboxylase	unknown	unknown	gnl\|CDD\|239424
NZ_CP036259.1\|WP_144351699.1\|3896548_3896932_-\|exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NZ_CP036259.1\|WP_170233319.1\|3886753_3887101_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP036259.1\|WP_144351696.1\|3891738_3893475_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_CP036259.1\|WP_144351684.1\|3878128_3878875_-\|UTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|225099
NZ_CP036259.1\|WP_144351688.1\|3883760_3884246_+\|CarD-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224248
NZ_CP036259.1\|WP_144351689.1\|3884351_3885608_-\|fibronectin-type-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|277318
NZ_CP036259.1\|WP_144352975.1\|3890772_3891690_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|274216
NZ_CP036259.1\|WP_170233318.1\|3879014_3880448_-\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NZ_CP036259.1\|WP_144351692.1\|3887028_3887280_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|153418
NZ_CP036259.1\|WP_144351701.1\|3897468_3897711_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351700.1\|3897278_3897446_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|179769
NZ_CP036259.1\|WP_144351687.1\|3881985_3883188_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
NZ_CP036259.1\|WP_144351698.1\|3894221_3896456_-\|CRISPR-associated-helicase-Cas3'	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP036259.1\|WP_144351697.1\|3893471_3894206_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl\|CDD\|187782
NZ_CP036259.1\|WP_144351683.1\|3877488_3878127_-\|cobalamin-B12-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|239021
NZ_CP036259.1\|WP_144351693.1\|3888752_3889043_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144351694.1\|3889052_3890084_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NZ_CP036259.1\|WP_144351695.1\|3890080_3890776_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	8.4384e-33
NZ_CP036259.1\|WP_144351690.1\|3885628_3886180_-\|3'-5'-exoribonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	2.07643e-78
NZ_CP036259.1\|WP_144351686.1\|3880586_3881957_-\|uroporphyrinogen-decarboxylase	gnl\|CDD\|239424	cd03308, CmuA_CmuC_like, CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC.	1.04145e-89
NZ_CP036259.1\|WP_144351699.1\|3896548_3896932_-\|exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	2.83704e-50
NZ_CP036259.1\|WP_170233319.1\|3886753_3887101_-\|hypothetical-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.42796e-11
NZ_CP036259.1\|WP_144351696.1\|3891738_3893475_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	0
NZ_CP036259.1\|WP_144351684.1\|3878128_3878875_-\|UTRA-domain-containing-protein	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	3.27472e-53
NZ_CP036259.1\|WP_144351688.1\|3883760_3884246_+\|CarD-family-transcriptional-regulator	gnl\|CDD\|224248	COG1329, COG1329, Transcriptional regulators, similar to M. xanthus CarD [Transcription].	1.98992e-47
NZ_CP036259.1\|WP_144351689.1\|3884351_3885608_-\|fibronectin-type-III-domain-containing-protein	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.00925e-36
NZ_CP036259.1\|WP_144352975.1\|3890772_3891690_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|274216	TIGR02589, conserved_hypothetical_protein, CRISPR-associated protein Cas7/Csd2, subtype I-C/DVULG. This model represents one of two closely related CRISPR-associated proteins that belong to the larger family of TIGR01595. Members are the Csd2 protein of the Dvulg subtype of CRISPR/cas system. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. The related model is TIGR02590, the Csh2 protein of the Hmari CRISPR subtype.	5.19751e-148
NZ_CP036259.1\|WP_170233318.1\|3879014_3880448_-\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	3.74849e-09
NZ_CP036259.1\|WP_144351692.1\|3887028_3887280_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|153418	cd07377, WHTH_GntR, Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators. This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.	2.23609e-08
NZ_CP036259.1\|WP_144351700.1\|3897278_3897446_+\|hypothetical-protein	gnl\|CDD\|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	1.1729e-13
NZ_CP036259.1\|WP_144351687.1\|3881985_3883188_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.44911e-52
NZ_CP036259.1\|WP_144351698.1\|3894221_3896456_-\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.8121e-52
NZ_CP036259.1\|WP_144351697.1\|3893471_3894206_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	1.03884e-93
NZ_CP036259.1\|WP_144351683.1\|3877488_3878127_-\|cobalamin-B12-binding-domain-containing-protein	gnl\|CDD\|239021	cd02070, corrinoid_protein_B12-BD, B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or monomethylamine, which is initiated by a series of corrinoid-dependent methyltransferases.	2.52138e-54
NZ_CP036259.1\|WP_144351693.1\|3888752_3889043_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.63333e-34

>NZ_CP036259.1|WP_144351692.1|3887028_3887280_-|GntR-family-transcriptional-regulator
MSLDFSNFVSIQLSKEDKRPLYVQLYEYLLELIVSGRLSYGYLLPPVRKLASLLGLIPVLWWGPTNCWNKTAMSFPGPAAAAM
>NZ_CP036259.1|WP_170233319.1|3886753_3887101_-|hypothetical-protein
MVGAYKLLEQNGYVFSRAGSGSYVAESTGRPDDESPAGTAADTVEVMPNRPVPASGIDFATVMPPPDLLPIDDFKNILIEVLDRDKGNAFSYQDSQGFQPLRGAILTSAGDQDPG
>NZ_CP036259.1|WP_144351690.1|3885628_3886180_-|3'-5'-exoribonuclease
MNYVAIDFETANSSRASACSLAAITVENGAIVRTAYSLIRPPVLQFNYWNTKIHGLTAAHVQDKPTFAELWDRIRPHLEHKIVIAHNAAFDISVLRGMLNEYGLPYPAFRYACTVDIARKVWSDLENYKLSTLARRFAIEFEHHNALHDARTCALIALLAKAEAQASSFMHLADILQISLREF
>NZ_CP036259.1|WP_144351689.1|3884351_3885608_-|fibronectin-type-III-domain-containing-protein
MRKPLIFVQILCLIAVILLSSTALLSAAIMPAPNAWPDHITLTWTDDPATTQTITWRTGAATVGGQAEYAEAADFIAFPAGARAAAGIEVLRTNTGDMAIHSVTLTGLKPGTRYLYRVGTPDHWSEPHAFTTAGAQVPGFKFLVFGDSQSINYGVWQTTLRQAFQANRDAVFFTNVGDLVDVGQDYTHWAGWFSAARGVIDTIPAMPVAGNHECYTPARQFSKPVFFTAQFKLPQNGPAGLKGQVYSFDYGDVHFIMLDSQAGEQRQFEPDMLHKQSRWLQRDLMLTDKKWKIAFIHRPLYNNKPNPENPSLRQVFGPIFDQYHVDLVFTGHDHVYARTYPLYGGAAAGSPAGGTIYVASGRSGTKTYLNTAAKEWNRFFHNPVAAATYITVETGGHWLRVNAFSHSGLLIDAWEINK
>NZ_CP036259.1|WP_144351688.1|3883760_3884246_+|CarD-family-transcriptional-regulator
MFQIGDKIFYPMHGGGIIESIEEKEMFGQKQLYYVVNIPHRNMQVMLPFDKTERLGMRPVVDPDKLDDVLSTFHNHGETELIMNDTQRQRANMSKMKTGDIYEEIAVIRDLLRIKNKRKLGMADKNMLDNVRQILISEVVLVKDIPHEQATNFLDEMFTVK
>NZ_CP036259.1|WP_144351687.1|3881985_3883188_-|MFS-transporter
METQMKKDEFNQYRWVVLALMFLCFLFTFVTRFAWPPLIPVIVPALGMKMTQAGAFMSAFYFGYVVTQIPAGVLADRFGVRLILAISLILEGVSTFGMGYMQGYDTGFWLRAVTGLGAGAVFAACSRALMEWFPAKERGIAFGIMLAAPSGGIVLSNYIVPALNQAFGWQGAFKSIGIATVLLGIAIYFLVRTTDEPKGEKSMLGGFKVVFGNRDILLTASAGFCLMWVELGTATWANAYIKKLGFSLADAGLVMILYGIGGVIAPMVSGYLSDRMGNRKKLLILSYVAIIPLTVYFGYQTTLSMLCIVGFAFGFCSYMANPQLTILISEFAGKEWAATANGISNFIFQLASMIGPVILGFSIDATGSFNTVWWMMAAGPLVGILLLLPVGRKSQTAAVN
>NZ_CP036259.1|WP_144351686.1|3880586_3881957_-|uroporphyrinogen-decarboxylase
MSLEMQKLYDERLGRYQATIALEPTDRIPIASGSCYLAEVYSGATNQEIIYDPDKWLQAEMAFIKDFPEIDTLRDNRVWAPLYDAVGCKTYKLPGRDLPPNQHFQFVEEEYMQADEYELLIQDPGLFMLNKFLPRVLGEYGSPDANRSHMAFLKAGMGQMMMNNIMRNRSLQLQTVCGMPQPTTGVFIAPFDVLGDVLRGLRGALMDTYRRPRQVLEACDVLVDVMVRFALSTADPLRRYPIFVPTHKACFMSPKQFDTFYWPSFKRVLEKLIAAGYTVRAYLEGDWKQHWHHFNELPQGKVLCDIDTQGDIFKAKADFGRQQAISGGIHDSTFILGTPAEVAERVHHLCETVGKGGGFIINGGCNIPYDTKPENFRAMIDTIMQYGWYDKNCKPVPKPPAAAASAPDDIARQYRITPWATRVKELGGVRGDEAMIQQPWDQLEAMAFNWLWTWTM
>NZ_CP036259.1|WP_170233318.1|3879014_3880448_-|S-layer-homology-domain-containing-protein
MKKVNKLLAIIPLALMSITMAGTPALTGTVSAAAATSFSDVPADHWAYDAVAKLAQAGIIDGYNDRTFRGDRVLTRYEFAIIVAKAMDNFERADENNKEIIDTLSAEFNSELNRLGARVAQVENKTNTWLGGETRMRYIANDPNPASGKRLSGSEQFDFRQRIKFWGRINEDISWIGRITTSGGNKFGSVNYPGSGSEISLDIMNVTVQGLLGSDNIRVGRSALDFYTTGLFGGPLNYDGVTINKRFGDVSFKGWTGTIRPSTEANKNQLSTAQVGFKVNNDLNVKTGYYWANAVGTSSPDGKGLLNTNRGSYDKSKGWSAGFDYKLGKYTLLGDYVGTSLVNARDGLGSNPKAWAVQFSNSQGPAVLYPAVNLVNPSKVGSDAWLVGYRSIDPGAIPNGAGGYDQTAVSNLAQPYNVSAHGTDNVNVLMLAYQNVIAKNLLLSLEYQDFKVKERGLTSLASDRLDKNYMVKFEFYY
>NZ_CP036259.1|WP_144351684.1|3878128_3878875_-|UTRA-domain-containing-protein
MDRINKNLFTPPFYQLATILEQRILAGEFKPGESLPSENDLGREYELSRTTVRKCLSLLAERGLISAQQGRGTFVSRPSLDRALFVMEEFTAKMAQEGKKTGHRLVHVRFRKELPEFAQKIGMLPSQGILYYCRLLSADGEAVAVEHKYMCYKKGRPILENEFQYMAFSEIIAIHTDFLPVRSQAMLTAESVSEFDAKYLQLVPGAPVLRLQQVLYTGDDQPVGIGVFYYRSDRYSLISDIQPLKGGR
>NZ_CP036259.1|WP_144351683.1|3877488_3878127_-|cobalamin-B12-binding-domain-containing-protein
MLALLANAISELDEPLALELVKKSLESGVYPLDIVEECRSGLIAVGERYSRGEYFLGDLILSSEIFSQIMDMIAPVVELAAKEPVIGKIVFGTIEGDIHDIGKNLVGSLLRCYGFEVYDLGVDVPPDKFMLALTESGAQILCLCTLLSPGFEALKRTIQLVRLLERNSKIKVLIGGLVNEKVREYTGADAWVDDARQGVEICLDWSKAIAQK
>NZ_CP036259.1|WP_144351693.1|3888752_3889043_-|CRISPR-associated-endonuclease-Cas2
MLVLITYDVSVTTDAGKRRLRRVAKQCVNYGQRVQNSVFECLVDPTQFAELKHRLEAIIDVETDSLRYYFLGNNWKNRIEHIGAKTAYDPEGVLMI
>NZ_CP036259.1|WP_144351694.1|3889052_3890084_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MRRLLNTLYVTMPDAYLACDGENVVIRVKDETKFRVPVHNLESIICFGFAGASPKLMYLCSERGVALSFLTEYGKFMGRVTGGISGNVLLRRAQYRWADDPTVSARLARRFIAAKIMNSRALLHRLRRDHKETVDSLALDKAITWLAGTADRLEKAGNGDVIRGVEGEAAQVYFSNFNQLILSQKEEFYLFNRNRRPPTDRINALLSFLYTLLAHDVTSAIESVGLDPQVGFLHRERPGRPSLALDIMEELRPHFADRLAVTLINRKQISADGFVVKENGAVIMAEDTRKEVLTAWQKRKLEEITHPYLEEKISLGLVPYVQALLLARHIRGDIEDYPPFFWK
>NZ_CP036259.1|WP_144351695.1|3890080_3890776_-|CRISPR-associated-protein-Cas4
MTEHYLDEDLLLLSGIQHMAFCERQWALIHVEQVWAENVRTVEGKHFHERADDPFFDESRKTVRIVRSMPLVSHRLGLRGVADVVEFHHSKPEISGETCQLKDREGWWRPLPVEYKRGKPKKDGRDAVQLCAQAVALEEMLGLTITSGCLFYGETKRREAVEFTPALRQHTMELSRKMHVLVREGITPKAKKGKRCAQCSLVDDCQPYWMLRHRPVAAYLARMCSLEADEQ
>NZ_CP036259.1|WP_144352975.1|3890772_3891690_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSISNPIQKRYDFVILFDVKDGNPNGDPDAGNLPRIDAETGHGLITDVCLKRKVRNYVGLKNSDNPPHGIFVKEKAILNKVIEQAYISLDINLQEVPKDVTDGNKRNKAGQGQGKEVERAKQFLCQNFFDIRTFGAVLSTGANAGQVRGPVQFTFARSVDPVVALEHSITRMAVATEAEAEKQGGDNRTMGRKFTIPYGLYRAHGFISAPLANQTGFSKDDLEILWEALDLMFEHDRSAARGLMGTRKLIIFEHSSAMGNAPAQQLFDAITVKKKDDNKPARDFGDYTISVDKTKIPQGVTLIER
>NZ_CP036259.1|WP_144351696.1|3891738_3893475_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILQALKEYYDRKAADPESDIAPEGFEKKELQFLIVIDAKGNFLNIEDTRERIGKRLVGKSFLLPRSVGRSGNKSYETTFLLWDHIGYLLGQPIGDPKSSKQHQTWLAALSRLDSGLLTDVGVNAIIEFYNNNELERAIASPQLKECLKAPQCNMSFRLISDMCPVPCRSKVQEFVRNNTTRIIDKEVSEEKEQTGICLITGEFGVIARTHSRTPINKDTKCLVGFQKNSGYDSYGKEQGYNAPISKSTEFTYVTGLNTLLKSSSQRLLIGDASTIFWSEKPSSFESDFSFFFKEPEKDNPDIGTEKIKALFESVNSGAYRDDDSTSRFYILGLSPNAARISVRFWHVGTIAEFAGRIRQHFEDFAIIKLSREPEYYSLWRTLVNIAVQDESENIPPNLAGDFMRAILNGTPYPATSLQAVIRRIGSDTENRVKPVRAALIKAYLNRYHRFYPNKNHKEVTMELDVSQPSIGYQLGRLFATLEKIQEEANPGINATIRERFYGAACATPVTVFANLLRLKNHHLAKLENRGRVVNFERMLGDIVSKITDFPAHLDLHEQGRFAIGYYHQRQAFFIKKE
>NZ_CP036259.1|WP_144351697.1|3893471_3894206_-|type-I-C-CRISPR-associated-protein-Cas5
MHNWCLEVWGDYACFTRPEMKVERVSYDVMTPSAARAIFEAILWKPAIKWNVTRIEVLNPIRWISVRRNEVGGIVTNPTARQMAGESSEPLGIFIEEKRQQRAGLFLRDVRYRIHGYFEFTPPEKRKANNLLLSEVWADDQENAEIVRLDEIEAKYAAMFERRAKKGQCFHRPYLGCREFACDFRLVDEDLEPAKLINETRDLGYMLYDMDFERNIKSPPPLFFRAEIKDGGINTDRREVEVRG
>NZ_CP036259.1|WP_144351698.1|3894221_3896456_-|CRISPR-associated-helicase-Cas3'
MDNNEWIAHVRKDDEEKWGFPHLLLDHLRGTASLTEQFADKFQSGKWGKTLGLAHDAGKGRLDWQKYIRHKSGYDDEAHLEGKVGKIPHAIYGAKLVEDLFGKAIGRFLAYGIAGHHAGLPDWSNAEGAGTSSLQFQASQIKDIHDIADFIINELQPIKFANPPWRFSSEGLDFSLWIRMLYSCLVDADFLDTEAYMDKERADTRGSYCNITELLERFDWYIRQLESKSRNTHVNQIRRQVRNKCVQMARESRGVFSLSVPTGGGKTLSSLAFCLEHAKKHDLDRVIYVIPYTSIIEQNADVFKAALGKEQIVEHHSSLGEEDSTPKSRLASENWDAPVIVTTSVQFFESLFAAKSSRCRKLHNIVNSVIVLDEAQLVPVDYLLPILEAMQLLVDHYRVSFVISTATQPAFKERLVDGKNFPGLKNVKEIMGNGVTDLYASLKRTQVNLPKDIHSVTSWEEIAQELVQYEQVLCVVSDRKSCRELHRLMPKGTIHLSALMCGQHRSEVIEAVKQKLKNGESVRVISTQLVEAGVDMDFPVVYRALAGLDSIAQAAGRCNREGNLSDLGKVIVFNAPKKPPLGILRKAADTTRSILATTCQDPLHHSLFEQYFSELYWKANSLDVKEIVKLLTPSPQDCGVYFRTAAERFKLIDDSRQKTILVRYDEGNTWIDLLRFQGPDRTLLRKLQRYTVNISKETFNDMLRRGVISEIQPGIFALTSEMDYSQAVGLVLGDDAYEAEILIV
>NZ_CP036259.1|WP_144351699.1|3896548_3896932_-|exonuclease
MQAYFTAFDFETANFQSHSACQLGLAVVENGRIVLEKAWLIRPPTKVFTFSYLHGITYSMVKSQPTFGEVWPEARPFFERQIIAAHNADFDIGVLLATLTHYGLFMPEFYVIDTLAVARSAWHSVAD
>NZ_CP036259.1|WP_144351700.1|3897278_3897446_+|hypothetical-protein
MQNRYELNKNLAQMLKGGVIMDVTYAEQAKIAEAAADKIVAVEQNNMPAIAFIRN
>NZ_CP036259.1|WP_144351701.1|3897468_3897711_-|hypothetical-protein
MEKMFKRLLSNTLSFATTLLIMAAPVAAVIYASEPATAVESFSLAESTPAAAYAQAPNNEHPLYDIYEGDDLVRSTFSPK

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Crispr_ID: NZ_CP036259_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_14

3964545-3965089

TypeI-B

Consensus_repeat	Method
GTTTCAATACATCCATGTTACGGTCAAAG	CRISPRCasFinder
GTTTCAATACATCCATGTTACGGTCAAAG	CRT
GTTTCAATACATCCATGTTACGGTCAAAG	PILER-CR

8 spacers

DinG,cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1

The CRISPR arrays of NZ_CP036259_14

>merge|NZ_CP036259|14|3964545-3965089|CRISPRCasFinder,CRT,PILER-CR
CTTTCTCTACATCCATGTTACGGTCAAAGGGATGAGGACAAGACCTTCACCCGCCTGGCCGTGGGGTTTCAATACATCCATGTTACGGTCAAAGATGGAAAAACTTAAAACTTGCTCCGCAGATTATTTGTTTCAATACATCCATGTTACGGTCAAAGTGGCTAACAATACCATAGGGTAATGTCGGTGGTCCTGTTTCAATACATCCATGTTACGGTCAAAGCAAGATTAATATACTCAGTGGTCAGGTAGATTGCTTGTTTCAATACATCCATGTTACGGTCAAAGATACCGTAAGGTTCCAGTGGCGGCGCTGCTGGTTGAGTTTCAATACATCCATGTTACGGTCAAAGGGCGGCGCTTTTTGTGCCTTCTCCGACCGCATCAAGTTTCAATACATCCATGTTACGGTCAAAGGTATTCAATTACTTCAGAATCTCCAGATACACTTGTTTCAATACATCCATGTTACGGTCAAAGCAGGCTCGATTTGTACTGCAAGAATCAAATGTTATTGTTTCAATACATCCATGTTACGGTCAAAG

>NZ_CP036259|14|14|3964545-3965089|CRISPRCasFinder
CTTTCTCTACATCCATGTTACGGTCAAAG	GGATGAGGACAAGACCTTCACCCGCCTGGCCGTGGG
GTTTCAATACATCCATGTTACGGTCAAAG	ATGGAAAAACTTAAAACTTGCTCCGCAGATTATTT
GTTTCAATACATCCATGTTACGGTCAAAG	TGGCTAACAATACCATAGGGTAATGTCGGTGGTCCT
GTTTCAATACATCCATGTTACGGTCAAAG	CAAGATTAATATACTCAGTGGTCAGGTAGATTGCTT
GTTTCAATACATCCATGTTACGGTCAAAG	ATACCGTAAGGTTCCAGTGGCGGCGCTGCTGGTTGA
GTTTCAATACATCCATGTTACGGTCAAAG	GGCGGCGCTTTTTGTGCCTTCTCCGACCGCATCAA
GTTTCAATACATCCATGTTACGGTCAAAG	GTATTCAATTACTTCAGAATCTCCAGATACACTT
GTTTCAATACATCCATGTTACGGTCAAAG	CAGGCTCGATTTGTACTGCAAGAATCAAATGTTATT
GTTTCAATACATCCATGTTACGGTCAAAG

>NZ_CP036259|14|8|3964545-3965089|CRT
CTTTCTCTACATCCATGTTACGGTCAAAG	GGATGAGGACAAGACCTTCACCCGCCTGGCCGTGGG
GTTTCAATACATCCATGTTACGGTCAAAG	ATGGAAAAACTTAAAACTTGCTCCGCAGATTATTT
GTTTCAATACATCCATGTTACGGTCAAAG	TGGCTAACAATACCATAGGGTAATGTCGGTGGTCCT
GTTTCAATACATCCATGTTACGGTCAAAG	CAAGATTAATATACTCAGTGGTCAGGTAGATTGCTT
GTTTCAATACATCCATGTTACGGTCAAAG	ATACCGTAAGGTTCCAGTGGCGGCGCTGCTGGTTGA
GTTTCAATACATCCATGTTACGGTCAAAG	GGCGGCGCTTTTTGTGCCTTCTCCGACCGCATCAA
GTTTCAATACATCCATGTTACGGTCAAAG	GTATTCAATTACTTCAGAATCTCCAGATACACTT
GTTTCAATACATCCATGTTACGGTCAAAG	CAGGCTCGATTTGTACTGCAAGAATCAAATGTTATT
GTTTCAATACATCCATGTTACGGTCAAAG

>NZ_CP036259|14|7|3964546-3965089|PILER-CR
TTTCTCTACATCCATGTTACGGTCAAAGG	GATGAGGACAAGACCTTCACCCGCCTGGCCGTGGGG
TTTCAATACATCCATGTTACGGTCAAAGA	TGGAAAAACTTAAAACTTGCTCCGCAGATTATTTG
TTTCAATACATCCATGTTACGGTCAAAGT	GGCTAACAATACCATAGGGTAATGTCGGTGGTCCTG
TTTCAATACATCCATGTTACGGTCAAAGC	AAGATTAATATACTCAGTGGTCAGGTAGATTGCTTG
TTTCAATACATCCATGTTACGGTCAAAGA	TACCGTAAGGTTCCAGTGGCGGCGCTGCTGGTTGAG
TTTCAATACATCCATGTTACGGTCAAAGG	GCGGCGCTTTTTGTGCCTTCTCCGACCGCATCAAG
TTTCAATACATCCATGTTACGGTCAAAGG	TATTCAATTACTTCAGAATCTCCAGATACACTTG
TTTCAATACATCCATGTTACGGTCAAAGC	AGGCTCGATTTGTACTGCAAGAATCAAATGTTATTG
TTTCAATACATCCATGTTACGGTCAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144351759.1\|3966582_3967077_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP036259.1\|WP_144351754.1\|3958678_3961057_-\|DEAD/DEAH-box-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NZ_CP036259.1\|WP_144351752.1\|3955862_3956852_+\|type-II-asparaginase	unknown	unknown	gnl\|CDD\|199208
NZ_CP036259.1\|WP_144351750.1\|3954441_3954783_-\|DUF3870-domain-containing-protein	unknown	unknown	gnl\|CDD\|372419
NZ_CP036259.1\|WP_144351757.1\|3965268_3965550_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP036259.1\|WP_144351751.1\|3955028_3955799_+\|exodeoxyribonuclease-III	unknown	unknown	gnl\|CDD\|197321
NZ_CP036259.1\|WP_144351762.1\|3970592_3971543_-\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP036259.1\|WP_144351760.1\|3967073_3969734_-\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|273707
NZ_CP036259.1\|WP_144351755.1\|3961279_3961486_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351763.1\|3971544_3973389_-\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
NZ_CP036259.1\|WP_144351766.1\|3977963_3978515_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351761.1\|3969792_3970590_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP036259.1\|WP_144351756.1\|3964157_3964412_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351765.1\|3974874_3976104_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379306
NZ_CP036259.1\|WP_144351753.1\|3957171_3958611_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|236977
NZ_CP036259.1\|WP_144351764.1\|3973410_3974115_-\|CRISPR-associated-protein-Cas6	unknown	unknown	gnl\|CDD\|273848
NZ_CP036259.1\|WP_144351749.1\|3953108_3954200_-\|dipeptide-epimerase	unknown	unknown	gnl\|CDD\|239435
NZ_CP036259.1\|WP_144351748.1\|3951664_3953041_-\|C4-dicarboxylate-transporter-DcuC	unknown	unknown	gnl\|CDD\|225611
NZ_CP036259.1\|WP_144351758.1\|3965558_3966569_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP036259.1\|WP_170233323.1\|3961643_3963671_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144351754.1\|3958678_3961057_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	8.04347e-75
NZ_CP036259.1\|WP_144351748.1\|3951664_3953041_-\|C4-dicarboxylate-transporter-DcuC	gnl\|CDD\|225611	COG3069, DcuC, C4-dicarboxylate transporter [Energy production and conversion].	1.86904e-133
NZ_CP036259.1\|WP_144351757.1\|3965268_3965550_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	9.97254e-25
NZ_CP036259.1\|WP_144351751.1\|3955028_3955799_+\|exodeoxyribonuclease-III	gnl\|CDD\|197321	cd09087, Ape1-like_AP-endo, Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases. This subfamily includes human Ape1 (also known as Apex, Hap1, or Ref-1) and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Ape1 and Ape2 in humans. Ape1 is found in this subfamily, it exhibits strong AP-endonuclease activity but shows weak 3'-5' exonuclease and 3'-phosphodiesterase activities. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes exonuclease III (ExoIII) and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	6.1557e-160
NZ_CP036259.1\|WP_144351762.1\|3970592_3971543_-\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.31408e-32
NZ_CP036259.1\|WP_144351760.1\|3967073_3969734_-\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	3.98168e-23
NZ_CP036259.1\|WP_144351759.1\|3966582_3967077_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.056e-49
NZ_CP036259.1\|WP_144351761.1\|3969792_3970590_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	4.84949e-31
NZ_CP036259.1\|WP_144351765.1\|3974874_3976104_-\|AAA-family-ATPase	gnl\|CDD\|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	7.58652e-48
NZ_CP036259.1\|WP_144351753.1\|3957171_3958611_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|236977	PRK11776, PRK11776, ATP-dependent RNA helicase DbpA; Provisional.	3.35889e-151
NZ_CP036259.1\|WP_144351764.1\|3973410_3974115_-\|CRISPR-associated-protein-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	5.87394e-08
NZ_CP036259.1\|WP_144351749.1\|3953108_3954200_-\|dipeptide-epimerase	gnl\|CDD\|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	1.60628e-125
NZ_CP036259.1\|WP_144351750.1\|3954441_3954783_-\|DUF3870-domain-containing-protein	gnl\|CDD\|372419	pfam12986, DUF3870, Domain of unknown function (DUF3870). A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins, suggesting it may have a lytic function.	5.26232e-41
NZ_CP036259.1\|WP_144351758.1\|3965558_3966569_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	3.75192e-133
NZ_CP036259.1\|WP_170233323.1\|3961643_3963671_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	3.93699e-63
NZ_CP036259.1\|WP_144351752.1\|3955862_3956852_+\|type-II-asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	3.25017e-149

>NZ_CP036259.1|WP_144351756.1|3964157_3964412_-|hypothetical-protein
MALLFQLGPNQLGALTAILAILWAEDLDLDELNSLGNFFEALGSVMLAIAAQKQLLQQHQAEKQTPPESEQIQELIRRIQKLES
>NZ_CP036259.1|WP_170233323.1|3961643_3963671_-|methyl-accepting-chemotaxis-protein
MQINNSIRKKLLMMLLPFFILSFGILSTVSYYLSKQSLAISTEATAVAVGNDYANRLQANVMKLMTHLEDLASVPVMQNANDRAQMIAMMAETKQRVGVFDNVAFIYLDGLAVRLDGSTAKLGDREYFRKVVDTQKAYASEPLIARATGKAAVNLAVPVFNGGKLTGVLVGNYSLEGLSKLMQGVKFADSGYGFVCDDSGLLIAHPTMPEIVNKLDLSKKQVDPELKLKETELDDKLLHLFQASLDQPAVGEYRFGNIKQTGVFTPVNLPGGQRWITVVAAPAAELTKAASGLARTVLLVSLVFTIVAVIFVVVLSKRFAGPIQLIRDECLLLAGGDFRELQASVQSADEIGQLAQGFRTMRNNLRNLVTKVQLQAEQVAASSEELTASAQQSAEAANQMAVSITEMAQGAEQQAGLSSQISVVSSQISVRAEEISATMQEAAEIAGNTAQEAEQGRQAVEQAVGQMNKIGQGSEAVQAAITELAQGSQAIREIVSLISNIAGQTNLLALNAAIEAARAGEYGRGFAVVAEEVRKLAEESNQAAHQIGELIQKNQVNMDQAVAATQAGASGIKEGIAVVDTAGETFQKIVGAIMQLSAQIKEISEAINQMAEGSRTLVTSIQEIDQVNKKNNGEVQTVSAATEEQSASMEEIASSSNNLAKLAADLQEAVEKFKL
>NZ_CP036259.1|WP_144351755.1|3961279_3961486_-|hypothetical-protein
MNQDILNQNDANTQKLNWEAFIKQDVLNFLMAHNLQAITVDDGAGKKGVIKRSAKGELAVQITSNEKL
>NZ_CP036259.1|WP_144351754.1|3958678_3961057_-|DEAD/DEAH-box-helicase
MSENKVIKTSVRNLVEFVLRAGDLVAAFTGSSRLADGAKIHRKLQQAQTSEYQPEVSLAITVTWADLVLQISGRADGVITTIAETGLAEITIDEIKSVTQELETIEAGYNQLHWAQAKCYAYIYAVQHELERIGVQLTYCQAATLETKLFKQIYPVQELAAFFEALISDYAMWAQRLGDWAASRDASAGLVRFPFSGFRPGQRQLSVAVYKTICGGVKLFAQAPTGTGKTMAVIFPAIKALGLGHVEKIFFLTAKTVTRQLAEAAFDRLRQAGLQCKTLTLTAKDKICFRPDSACTPEECPYAAGYYDRIKPALHHCWPEAAFTREVIEQYAREYRVCPFELSLELAFWADAVICDYNYVFDPRVYLKRFFSENSGQYCFLVDEAHNLVDRAREMFSAAITKQSFLGIKKTVNNKLPALAKAAGKINTFLLKLGKLCIDKTAAGETDYFVREQACSEVLPLLRKFMDLAEKWLAKNEQAEFREELLDSYFMANAFLRTAETYDERYVTYAEKIDKDVKLKLFCVNPAELLRQAGLRGRATVFFSATLTPVDYFFEILGGGEGDGRIAVPSPFAAGNLRLLVADHISTTYKTRAQTYDVIVDSITAAITAKTGNYLVFLPSYRYMEEVGRRFCLQNPRISVSKQTGEMTEAERAGFLAQFSADSTETLVGFAVLGGVFGEGIDLTGERLVGAVIVGVGLPKVCLEREIIRQWFNQNNRQGFEYAYVYPGMNKVLQAAGRVIRTEQDRGLVLLIDERFSQARYKRLFPREWQGAVRTNSVSRIGAALKQFWLLQ
>NZ_CP036259.1|WP_144351753.1|3957171_3958611_-|DEAD/DEAH-box-helicase
MKIIDGFSKEIKKALVTLGYETLTEVQTQVIPLVFAEQDIIVQSQTGSGKTAAFAIPVCEKIAIEQRSPQALVLTPTRELAVQVKQDIANIGRFKKIRCAAIYGRQPMAIQRRELSQRVHVIVGTPGRTFDHTVSGSINLAAIKYLIIDEADKMLDMGFIEQVEAIIAKLPGNRVTLVFSATMPEQIQAICSRYMLAPVRLAVESASPAAATIQQGYYEVEESGKLRLVKKIAVTERPDSCILFCNTREKAELVAAELKHAGYLCGTLHGGMEQRERLAAIQGFKRGEFRFLIATDVAARGIHVAEIALVINYDFPLDHEGYVHRIGRTGRAGNAGAALTFVTLAERRALAAIEEFVQYKIPRLEQPTGAAVERGNMISEHDKAKPAYKPDISDKLNSEITRIRINAGKKTKMRPGDILGAVTAIAGVSAGDIGIIDVQETCSYVEILDGKGPLVMAALQATKIKGRLYTTKQVGFRTI
>NZ_CP036259.1|WP_144351752.1|3955862_3956852_+|type-II-asparaginase
MKKITILATGGTIAGVAPFPAGTVSYQPAVVPIQELLEQIGSLPGIAAATSEQLAQIDSADMNHGIWLQLANRLNALLQQPTVDGVVVTHGTDTLEETAYFLNLVVKSPKPVVLVGAMRPSTAISPDGPMNLYNAIILAASPSAWDKGVLVALNDTINCSRDVTKTNTSLQDTFKAPELGYLGYIIDNQPHFYRLPTRRHTYLTEFDITGLNELPPVDILYGHVNDYGTLAQAAVAAGAQGLVYAGLGNGNLSQHMRQVLGNIQQQGVVVVRGTRVCNGAVTRNGALDDEQYNFVVADTLSPQKARILLMLALTKTRNPAKIQNMFWIY
>NZ_CP036259.1|WP_144351751.1|3955028_3955799_+|exodeoxyribonuclease-III
MKLISWNVNGLRACLGKGFGDFFTGAGADIFCIQETKMQQDQSELVLPGYEQYWNSAVKKGYSGTAVFTRLKPLAVTWGLGIEEHDQEGRLITLEFDEFYLVNVYTPNSQRGLLRLEYRLRWESDFRNYLLQLDRNKPVVMCGDLNVAHEEIDIKNPKANRKNAGFTDEERNSMTVLLASGFTDSFRALYPEKRDAYTWWSYMMNARARNIGWRIDYFIVSDRLKDVIAAAHIYPDIMGSDHCPVGLELHPPLSPQ
>NZ_CP036259.1|WP_144351750.1|3954441_3954783_-|DUF3870-domain-containing-protein
MFADNTIYIVGNAKSQQNNPITHHYGQFFIGFVVERETGRIVACGSSATVPTTAEFIGSLFAGKSMQDEFELMRQHVEARYFGSSQKAILVAYKDAQKKFFRIMNGMPLDLND
>NZ_CP036259.1|WP_144351749.1|3953108_3954200_-|dipeptide-epimerase
MKIAAIRIGKVSIPLKKPFKTALRQVHSAEDIIIKMIADTGETGFGNAPPTAVITGDSQDSIIAAIRDTIGPKLIGMDVDNLEGIMTTIDAAMLHNSSAKAALDIAVYDLFGKRHGIPLYKLLGGYRQGITTDLTISINAPEEMVADSLAAVAAGYTELKLKVGTEAALDIQRVQAIRAAVGQDVKIRLDANQGWSPKEAVRTIRKFEDMGLGIELIEQPVPAHDFAGLKYVTDQVETDIMADESAFGAYEVFQLLAMRACDLINIKLMKAGGLHNAVKIAHLAETMGIQCMMGCMLESKVGITAAASLAAGKKIISTADLDAAVLLAEDPVIGGVSFSKNQLSISDAPGLGITDVQGWQEIQ
>NZ_CP036259.1|WP_144351748.1|3951664_3953041_-|C4-dicarboxylate-transporter-DcuC
MEVKKVGIILSLLVTFWVGYLIVKKYKPQPVLFMAGLILMFAAVALGLGQILPVKDSTGSVLFDAFEFIKQTMSSRAAGLGMNIMAVGGFARYMDHIGASKALVKLTIRPLLALRSPYLVMAGAWVLGMFLGLCINSASGLAMLLMVTVFPVLISLGVSRLSATAVIATTLCLDWSPSDTGTILSATTAGIDPVLYWTNYQIPIAIAVIPIVAVLHYVTQKWFDKRDGHVVQATELVADEADANMPPMIYAILPALPLALILAFSSLWITWIKMDIIKAMFIGVAIGMIFEYVRCRDGKKVLADIQSFFDGLGLQMANVITLIVAGETFAKGLMTIGTIDAIIASAQSSGFGAAGMILVMVGIIAIASVVMGSGNAPFFAFAALTPVVAAKMSVAPVVMLLPMHFAASAARAISPITAVIVVASSMGGVSPFDVVKRTAIPMIGALIVIIVANFVLFY
>NZ_CP036259.1|WP_144351757.1|3965268_3965550_-|CRISPR-associated-endonuclease-Cas2
MEKNYNYVILVYDIGEKRVGKVFKICKKYLVPFQKSVFRGEITPANLIKLRSELQKVIDKKVDFVALFKMTGDYVFDEEVIGVRLHNQEAMLL
>NZ_CP036259.1|WP_144351758.1|3965558_3966569_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MAKSAPTTRYIRTPGTLGREDNSLTFRNEKGITHIPINSLKELYLLNEISLNSKLFTFLSMANITVHFFDYYGQFRGTFYPKEARVSGKVMLLQAKACLENRLPIAVAFVGAIAANIHEVLYHYFKHGNKEIKPYLDWLKKEVPDLLPKIKKVPTLLSLEGEIWRRFYETFQLILPEDFVMNHRVKRPPDNPINALVSFGNTILYTKTISQIYHTHLDQTISFLHEPSDRRFSLSLDLSEAFKPLIVFRTIFEVVNNRRIQVSKHFDKKYNYCLLNEPGRDVFITAMEERLQQVFDHGTMKRKISYLTAIKYDAYKLKKHVVEGTPFTPFLEKDRR
>NZ_CP036259.1|WP_144351759.1|3966582_3967077_-|CRISPR-associated-protein-Cas4
MRITGTIVNYYIHCKRQCWLFAHKMNFEDDSEDVRTGRILHEIRSEGRNNTEIQIEGIKVDKMTEEYVVELKKSDADVEATKWQTLYYLYILKQKGLDRKGRLEFIERNKQNHRTVELELDKRTEPELIRLLDDIEVYLQQDKPVPAIYAKKCERCAYYAYCYI
>NZ_CP036259.1|WP_144351760.1|3967073_3969734_-|CRISPR-associated-helicase-Cas3'
MGIGDYLIDGAEILLAHTAKKGTGKQAESLVEHSDLVLHYVDELSEHNGLSSAIQRTVANLTVQDEPLPLAAQYWIVKCFRQAIYLHDLGKINPVFQKKKMGNQQIEKLSLPGDSNHALLSALLYLDIYLAELDEIEFPGDNALIGSFMKHVLYVFAYVISRHHTYLANAEDADGEETSFEKQLQLLQKKIQRYPGYVHYYRYKERVCSRDSAGRRDITGELLKNRYQRFTDTHSPFPFYVLTKLLYSTMAACDFYATYAYDAEKSLEFQYFSKKQELRPVLETFYNTAIYRGVQALRNNPQTTTLSSINRLRSALFLDTETELLRNLDKQLYYLEAPTGSGKTYMSINLGLKLLNSELGLNKLIYVFPFNALIEQTKLILDKIFPDELRNQYPMPVINSITPIISKKEETAETGNGETEPDFDYKSVLLQRQMLQYPVMLTSHVNFFNYLFGLGRESNLAFTHLCNSVVILDEIQSYKNAIWKEIIHFLQSFAKLLNMKVIIMSATLPNWDSLVEGESDTCSLVAKRELYFQHPLFCKRVQLHFELLQKKVITEEELLAEVLQRLKERRDQGKSTRLLIEFITKAAARSFYRCLQSAKLDSPLFELTGDDSNLLRKEVLKQLGKDEKGIFHLPDVIVVATQVIEAGVDIDMDIGFKDSSMLDSEEQFLGRINRSCLRPDCHAYFFNMVKTTLIYRDDQRTAYDLQTESCQKMLQDKDFSGFYRLVTARINAERQKANLKNWSYFTASVQQLQFKEVEAAMRLITEKQYTLFIAHEAAYKNTDGKEERLDGAQVWEEFKILLADRETEYAERIVKLSQIKEKMAYFTFNYGIQHSCKQTPPQIYTEVAGTLYYIPNGERFMELDENTGAKKFNRQAYIDAGVSPLL
>NZ_CP036259.1|WP_144351761.1|3969792_3970590_-|type-I-B-CRISPR-associated-protein-Cas5
MRALRFELKGETAFFKKPDVNSYAYFTYSHIHKIALFGLLGAILGHGGYMQQYDANYPLTTNRKQAKEVQVFPEFYEVFQQARISIVPHGDRGYFAKKLQIFNNTVGYASQEEGKVLNVREQWLEKPHWTIYVADDAGLAAGIFKKLAESLLQSQSVYMPYLGKNDHPAAITEPALVELSQAGQVKFIDSLHRSDALAYKVRGEIKPGQGKSFFKELMPVALNAENNGYVFHSLVVTNHEIDQASISEDDYRNLYCDGERVLYFI
>NZ_CP036259.1|WP_144351762.1|3970592_3971543_-|type-I-CRISPR-associated-protein-Cas7
MIKMKQRVIGLIGIVSRMANWNADFTGLPKTTSDGNIFGSDKALKYSIKRLWELNGEKVLYIRSYKLGKGKEGEKLQPRDLQERYQQLFGESVAKDSTIVLKRLFACVDVMNFGATFAVEGQNIGLTGAVQIGQGFNKYEETNVEVQDILSPFRNSNEKSLDKDATSIGKKIMVDEAHYIYPFTVSPNHYESYIGLPGLDEFQGYTQEAYAAFKEGALLGATALQTNSKSGSENAFSLFIVLKENALAYLPNLDPYVTVCKKEDKTMYDLSAIAPIVAGIQEQVEQIELYINPYAAEVLLELDGLKRYNIITRAAL
>NZ_CP036259.1|WP_144351763.1|3971544_3973389_-|hypothetical-protein
MIRDLAVGFQKAQEKFPAIIQDNYKLKEGVYIRLKLKQDWESQSAAFEKNHVTIVRKEEEPQNIELLNWFKCRDYLSSLVDMNKPVDPKKQVHSNNPFALFMKKEVFLGEKQGGKYTAEENINRYLLAAGRDPVRQKWLEMIPKNKNDKDNRQFFQASEYAVMLTYLESSERLQLIEEITKWYYSNLAALTEYIGQLSFKNYVKLFFTFDSSAPTLACERMYAFEYVLYTIPKIFNSNDYNQLVAGELVGLPNIDMTMNSKKPFLEHKTMGSQAPERVTLQQATLAKQTTEWLAAAKPPYATNKIGYESGFIPPTGYVPPEGTFHVYMDGKYNELYGFENVPFPPTTTVQVEWLNILQLKDPAGDEKYYGTIQDAEALQKTISSRFFRGRMNNSFIFNEPDVKAGEFTALMAALYLQSRQAFHDWFYKGTTISLQGIFAKVTLRLLVEQLVHVETSRMAELGDAFNLRLSIQMAIDDKGGKVMADRIKGTMEALRNKLVSEELAVCANDEEFYFMAGQLAHYLISQSRAQKITGEMYEPFLRAKNGHQLKKRLEEAYMLYKHEIFSGYHRFNQAFSLVLGYVPETDNQGSARELLLAGIFAYNLLFEKTVKGVE
>NZ_CP036259.1|WP_144351764.1|3973410_3974115_-|CRISPR-associated-protein-Cas6
MLFELKLTVLLKKSTHHLQMQEPIGNWISQAQLTDPLFKQTHYDKIYKHFVFSNLYPTEKDGIYQQGRIYVLTIRSSIEDTLNRIHQCLKKCRESDYFQLVACEQRTRRLGHITELLTITPAIVTIENQKPWTPEDNIELLIQRLEANAEKKFKSLYPDTLVQAGQTFIQGITIENRKPLATAYKGRKLLGNKLHLLIHEDEYAQKLANVVMGSGLAEKGSILGAGFCLAKYLK
>NZ_CP036259.1|WP_144351765.1|3974874_3976104_-|AAA-family-ATPase
MNYIHRAMEDTFLHLSKEFPALLLTGPRQVGKTTMLQKLAAEENIGREYVTLDDLTERQMAKNDPKMFLQIHKPPVYIDEVQYAPELFTYIKIHVDQNRRAGDFWLTGSQVFKLMEGIQESLAGRVCLLHMAPLSQAEIYGAATAPFVLALEQLSQRIKERTPIDTPALYERIFRGGMPALISGQHSDYRAVYSSYISTYIDRDVKELSGAIDSLKFMDFITAAAALCGQMLNYKTIADAAGIDQITAKNWLGILERLGIVFYLHPYSSNMLKRMVTKPKLYFYDCGLVAYLTKWSDSDTLMNGAMSGAILENFAVSEIVKSYQNCGWEAFIYYYRDKDTKEIDLLLEDSGKLYPMEIKKTATPQSQLTRVFGVIDKATLERGIGAVLCTTDRLSAFDSQNLIVPIWGI
>NZ_CP036259.1|WP_144351766.1|3977963_3978515_-|hypothetical-protein
MNKKKSTKIKIAVAVIVCTVIALVLIFNSAFGSMFSFIGNQYRNWEIGRLATTDLSNITVDTIRIGSNLEDVDLAAYQASNRFRNSGGDHAYYFDELILDVDDNKVSYIFAFDEDVLLNINGNKDISTIEEISGLLGENYLAKTEDREQRLIKHIYYDKEIRVVAEIVYSDYDGEFVWIALWR

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Crispr_ID: NZ_CP036259_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036259_15

3976287-3977483

TypeI-B

Consensus_repeat	Method
GTTTCAATACATCCATGTTACGGTCAAAG	CRT
GTTTCAATACATCCATGTTACGGTCAAAG	PILER-CR
GTTTCAATACATCCATGTTACGGTCAAAG	CRISPRCasFinder

18 spacers

cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

The CRISPR arrays of NZ_CP036259_15

>merge|NZ_CP036259|15|3976287-3977483|CRT,PILER-CR,CRISPRCasFinder
GTTTCAATACATCCATTACGGTCAAAGAGGCCATTTGGAAGTACATAATCCGGGAGATATCTAGTTTCAATACATCCATGTTACGGTCAAAGTTATAAACATAAGCATTGCCCCACGGATCAACAATGTTTCAATACATCCATGTTACGGTCAAAGCTGTTTCTGCCGTTAGGTTATATATCGATATCTCCGGTTTCAATACATCCATGTTACGGTCAAAGACAACTGAGTGGCCCTATACTTTTGCCATTTTTAAGTTTCAATACATCCATGTTACGGTCAAAGACGTGGTATCCCGTAATTCATTCACTCCTTTCCGCAGTTTCAATACATCCATGTTACGGTCAAAGAACAGTCGGCTGCCCCTTGAGAGATGATTTTATTGCGTTTCAATACATCCATGTTACGGTCAAAGATATCGGCAGGTGATGAAAATGTACGGCGAACACTGGTTTCAATACATCCATGTTACGGTCAAAGGAATTTTAACCCATCCATTGACCGGAGTTTAAACAGTTTCAATACATCCATGTTACGGTCAAAGGCCTACTTCGATTAACATATAATCACTCCCATGCCTTGTTTCAATACATCCATGTTACGGTCAAAGAAGTTAACACGCCATTTTTAATGGATATTTTAATGTTGTTTCAATACATCCATGTTACGGTCAAAGATGTTTTTCATGTAGACCACTGCCGAAGTCGCCATAGTTTCAATACATCCATGTTACGGTCAAAGTTTGTTCGCCGATGCCGAATGTTCTGGCAACTTCCTGTTTCAATACATCCATGTTACGGTCAAAGCTCTATTTCCCATTCCGGATAGGCTTGCGTGCGGAGGTTTCAATACATCCATGTTACGGTCAAAGAAGGATGACAAACGGCTCTCTATCCCAATTCAGCCGTTTCAATACATCCATGTTACGGTCAAAGCCATTAATCAGTATCCCCTCAGTAGAAATATTGATTGTTTCAATACATCCATGTTACGGTCAAAGTCGAACGATGGTTATATCCATTGTGGTTGAGGCTGCTAGTTTCAATACATCCATGTTACGGTCAAAGCATACCACCCATTCCCGGACAACCGCCAAATCGCTCGTTTCAATACATCCATGTTACGGTCAAAGTTGGCCCTGACATATTGGCGCTGATCCAAATAGAGAGTTTCAATACATCCATGTTACGGTCAAAG

>NZ_CP036259|15|9|3976287-3977483|CRT
GTTTCAATACATCCATTACGGTCAAAGAG	GCCATTTGGAAGTACATAATCCGGGAGATATCTA
GTTTCAATACATCCATGTTACGGTCAAAG	TTATAAACATAAGCATTGCCCCACGGATCAACAAT
GTTTCAATACATCCATGTTACGGTCAAAG	CTGTTTCTGCCGTTAGGTTATATATCGATATCTCCG
GTTTCAATACATCCATGTTACGGTCAAAG	ACAACTGAGTGGCCCTATACTTTTGCCATTTTTAA
GTTTCAATACATCCATGTTACGGTCAAAG	ACGTGGTATCCCGTAATTCATTCACTCCTTTCCGCA
GTTTCAATACATCCATGTTACGGTCAAAG	AACAGTCGGCTGCCCCTTGAGAGATGATTTTATTGC
GTTTCAATACATCCATGTTACGGTCAAAG	ATATCGGCAGGTGATGAAAATGTACGGCGAACACTG
GTTTCAATACATCCATGTTACGGTCAAAG	GAATTTTAACCCATCCATTGACCGGAGTTTAAACA
GTTTCAATACATCCATGTTACGGTCAAAG	GCCTACTTCGATTAACATATAATCACTCCCATGCCTT
GTTTCAATACATCCATGTTACGGTCAAAG	AAGTTAACACGCCATTTTTAATGGATATTTTAATGTT
GTTTCAATACATCCATGTTACGGTCAAAG	ATGTTTTTCATGTAGACCACTGCCGAAGTCGCCATA
GTTTCAATACATCCATGTTACGGTCAAAG	TTTGTTCGCCGATGCCGAATGTTCTGGCAACTTCCT
GTTTCAATACATCCATGTTACGGTCAAAG	CTCTATTTCCCATTCCGGATAGGCTTGCGTGCGGAG
GTTTCAATACATCCATGTTACGGTCAAAG	AAGGATGACAAACGGCTCTCTATCCCAATTCAGCC
GTTTCAATACATCCATGTTACGGTCAAAG	CCATTAATCAGTATCCCCTCAGTAGAAATATTGATT
GTTTCAATACATCCATGTTACGGTCAAAG	TCGAACGATGGTTATATCCATTGTGGTTGAGGCTGCTA
GTTTCAATACATCCATGTTACGGTCAAAG	CATACCACCCATTCCCGGACAACCGCCAAATCGCTC
GTTTCAATACATCCATGTTACGGTCAAAG	TTGGCCCTGACATATTGGCGCTGATCCAAATAGAGA
GTTTCAATACATCCATGTTACGGTCAAAG

>NZ_CP036259|15|8|3976350-3977483|PILER-CR
GTTTCAATACATCCATGTTACGGTCAAAG	TTATAAACATAAGCATTGCCCCACGGATCAACAAT
GTTTCAATACATCCATGTTACGGTCAAAG	CTGTTTCTGCCGTTAGGTTATATATCGATATCTCCG
GTTTCAATACATCCATGTTACGGTCAAAG	ACAACTGAGTGGCCCTATACTTTTGCCATTTTTAA
GTTTCAATACATCCATGTTACGGTCAAAG	ACGTGGTATCCCGTAATTCATTCACTCCTTTCCGCA
GTTTCAATACATCCATGTTACGGTCAAAG	AACAGTCGGCTGCCCCTTGAGAGATGATTTTATTGC
GTTTCAATACATCCATGTTACGGTCAAAG	ATATCGGCAGGTGATGAAAATGTACGGCGAACACTG
GTTTCAATACATCCATGTTACGGTCAAAG	GAATTTTAACCCATCCATTGACCGGAGTTTAAACA
GTTTCAATACATCCATGTTACGGTCAAAG	GCCTACTTCGATTAACATATAATCACTCCCATGCCTT
GTTTCAATACATCCATGTTACGGTCAAAG	AAGTTAACACGCCATTTTTAATGGATATTTTAATGTT
GTTTCAATACATCCATGTTACGGTCAAAG	ATGTTTTTCATGTAGACCACTGCCGAAGTCGCCATA
GTTTCAATACATCCATGTTACGGTCAAAG	TTTGTTCGCCGATGCCGAATGTTCTGGCAACTTCCT
GTTTCAATACATCCATGTTACGGTCAAAG	CTCTATTTCCCATTCCGGATAGGCTTGCGTGCGGAG
GTTTCAATACATCCATGTTACGGTCAAAG	AAGGATGACAAACGGCTCTCTATCCCAATTCAGCC
GTTTCAATACATCCATGTTACGGTCAAAG	CCATTAATCAGTATCCCCTCAGTAGAAATATTGATT
GTTTCAATACATCCATGTTACGGTCAAAG	TCGAACGATGGTTATATCCATTGTGGTTGAGGCTGCTA
GTTTCAATACATCCATGTTACGGTCAAAG	CATACCACCCATTCCCGGACAACCGCCAAATCGCTC
GTTTCAATACATCCATGTTACGGTCAAAG	TTGGCCCTGACATATTGGCGCTGATCCAAATAGAGA
GTTTCAATACATCCATGTTACGGTCAAAG

>NZ_CP036259|15|15|3976350-3977483|CRISPRCasFinder
GTTTCAATACATCCATGTTACGGTCAAAG	TTATAAACATAAGCATTGCCCCACGGATCAACAAT
GTTTCAATACATCCATGTTACGGTCAAAG	CTGTTTCTGCCGTTAGGTTATATATCGATATCTCCG
GTTTCAATACATCCATGTTACGGTCAAAG	ACAACTGAGTGGCCCTATACTTTTGCCATTTTTAA
GTTTCAATACATCCATGTTACGGTCAAAG	ACGTGGTATCCCGTAATTCATTCACTCCTTTCCGCA
GTTTCAATACATCCATGTTACGGTCAAAG	AACAGTCGGCTGCCCCTTGAGAGATGATTTTATTGC
GTTTCAATACATCCATGTTACGGTCAAAG	ATATCGGCAGGTGATGAAAATGTACGGCGAACACTG
GTTTCAATACATCCATGTTACGGTCAAAG	GAATTTTAACCCATCCATTGACCGGAGTTTAAACA
GTTTCAATACATCCATGTTACGGTCAAAG	GCCTACTTCGATTAACATATAATCACTCCCATGCCTT
GTTTCAATACATCCATGTTACGGTCAAAG	AAGTTAACACGCCATTTTTAATGGATATTTTAATGTT
GTTTCAATACATCCATGTTACGGTCAAAG	ATGTTTTTCATGTAGACCACTGCCGAAGTCGCCATA
GTTTCAATACATCCATGTTACGGTCAAAG	TTTGTTCGCCGATGCCGAATGTTCTGGCAACTTCCT
GTTTCAATACATCCATGTTACGGTCAAAG	CTCTATTTCCCATTCCGGATAGGCTTGCGTGCGGAG
GTTTCAATACATCCATGTTACGGTCAAAG	AAGGATGACAAACGGCTCTCTATCCCAATTCAGCC
GTTTCAATACATCCATGTTACGGTCAAAG	CCATTAATCAGTATCCCCTCAGTAGAAATATTGATT
GTTTCAATACATCCATGTTACGGTCAAAG	TCGAACGATGGTTATATCCATTGTGGTTGAGGCTGCTA
GTTTCAATACATCCATGTTACGGTCAAAG	CATACCACCCATTCCCGGACAACCGCCAAATCGCTC
GTTTCAATACATCCATGTTACGGTCAAAG	TTGGCCCTGACATATTGGCGCTGATCCAAATAGAGA
GTTTCAATACATCCATGTTACGGTCAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036259.1\|WP_144351771.1\|3986545_3988795_-\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|225127
NZ_CP036259.1\|WP_144351772.1\|3988944_3989571_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351767.1\|3978941_3980192_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP036259.1\|WP_144351758.1\|3965558_3966569_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
NZ_CP036259.1\|WP_144351764.1\|3973410_3974115_-\|CRISPR-associated-protein-Cas6	unknown	unknown	gnl\|CDD\|273848
NZ_CP036259.1\|WP_144351757.1\|3965268_3965550_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP036259.1\|WP_144351762.1\|3970592_3971543_-\|type-I-CRISPR-associated-protein-Cas7	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
NZ_CP036259.1\|WP_144351760.1\|3967073_3969734_-\|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|273707
NZ_CP036259.1\|WP_144351759.1\|3966582_3967077_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
NZ_CP036259.1\|WP_144351763.1\|3971544_3973389_-\|hypothetical-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
NZ_CP036259.1\|WP_144351773.1\|3989864_3990632_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351766.1\|3977963_3978515_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351761.1\|3969792_3970590_-\|type-I-B-CRISPR-associated-protein-Cas5	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
NZ_CP036259.1\|WP_144351756.1\|3964157_3964412_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351769.1\|3983181_3983997_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225117
NZ_CP036259.1\|WP_144351774.1\|3990934_3991888_+\|DUF362-domain-containing-protein	unknown	unknown	gnl\|CDD\|377193
NZ_CP036259.1\|WP_144351765.1\|3974874_3976104_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379306
NZ_CP036259.1\|WP_170233324.1\|3986406_3986574_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036259.1\|WP_144351770.1\|3984294_3985833_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|236901
NZ_CP036259.1\|WP_144351768.1\|3980525_3982763_-\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805

Protein	Function_ID	Function_description	E-value
NZ_CP036259.1\|WP_144351771.1\|3986545_3988795_-\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_CP036259.1\|WP_144351767.1\|3978941_3980192_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	2.34116e-148
NZ_CP036259.1\|WP_144351758.1\|3965558_3966569_-\|type-I-B-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	3.75192e-133
NZ_CP036259.1\|WP_144351764.1\|3973410_3974115_-\|CRISPR-associated-protein-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	5.87394e-08
NZ_CP036259.1\|WP_144351757.1\|3965268_3965550_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	9.97254e-25
NZ_CP036259.1\|WP_144351762.1\|3970592_3971543_-\|type-I-CRISPR-associated-protein-Cas7	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.31408e-32
NZ_CP036259.1\|WP_144351768.1\|3980525_3982763_-\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	2.21801e-100
NZ_CP036259.1\|WP_144351759.1\|3966582_3967077_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.056e-49
NZ_CP036259.1\|WP_144351761.1\|3969792_3970590_-\|type-I-B-CRISPR-associated-protein-Cas5	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	4.84949e-31
NZ_CP036259.1\|WP_144351769.1\|3983181_3983997_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	4.17923e-27
NZ_CP036259.1\|WP_144351774.1\|3990934_3991888_+\|DUF362-domain-containing-protein	gnl\|CDD\|377193	pfam04015, DUF362, Domain of unknown function (DUF362). Domain that is sometimes present in iron-sulphur proteins.	7.23676e-56
NZ_CP036259.1\|WP_144351765.1\|3974874_3976104_-\|AAA-family-ATPase	gnl\|CDD\|379306	pfam13635, DUF4143, Domain of unknown function (DUF4143). This domain is almost always found C-terminal to an ATPase core family.	7.58652e-48
NZ_CP036259.1\|WP_144351770.1\|3984294_3985833_-\|PAS-domain-containing-protein	gnl\|CDD\|236901	PRK11360, PRK11360, two-component system sensor histidine kinase AtoS.	3.32891e-62
NZ_CP036259.1\|WP_144351760.1\|3967073_3969734_-\|CRISPR-associated-helicase-Cas3'	gnl\|CDD\|273707	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3. This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.	3.98168e-23

>NZ_CP036259.1|WP_144351765.1|3974874_3976104_-|AAA-family-ATPase
MNYIHRAMEDTFLHLSKEFPALLLTGPRQVGKTTMLQKLAAEENIGREYVTLDDLTERQMAKNDPKMFLQIHKPPVYIDEVQYAPELFTYIKIHVDQNRRAGDFWLTGSQVFKLMEGIQESLAGRVCLLHMAPLSQAEIYGAATAPFVLALEQLSQRIKERTPIDTPALYERIFRGGMPALISGQHSDYRAVYSSYISTYIDRDVKELSGAIDSLKFMDFITAAAALCGQMLNYKTIADAAGIDQITAKNWLGILERLGIVFYLHPYSSNMLKRMVTKPKLYFYDCGLVAYLTKWSDSDTLMNGAMSGAILENFAVSEIVKSYQNCGWEAFIYYYRDKDTKEIDLLLEDSGKLYPMEIKKTATPQSQLTRVFGVIDKATLERGIGAVLCTTDRLSAFDSQNLIVPIWGI
>NZ_CP036259.1|WP_144351764.1|3973410_3974115_-|CRISPR-associated-protein-Cas6
MLFELKLTVLLKKSTHHLQMQEPIGNWISQAQLTDPLFKQTHYDKIYKHFVFSNLYPTEKDGIYQQGRIYVLTIRSSIEDTLNRIHQCLKKCRESDYFQLVACEQRTRRLGHITELLTITPAIVTIENQKPWTPEDNIELLIQRLEANAEKKFKSLYPDTLVQAGQTFIQGITIENRKPLATAYKGRKLLGNKLHLLIHEDEYAQKLANVVMGSGLAEKGSILGAGFCLAKYLK
>NZ_CP036259.1|WP_144351763.1|3971544_3973389_-|hypothetical-protein
MIRDLAVGFQKAQEKFPAIIQDNYKLKEGVYIRLKLKQDWESQSAAFEKNHVTIVRKEEEPQNIELLNWFKCRDYLSSLVDMNKPVDPKKQVHSNNPFALFMKKEVFLGEKQGGKYTAEENINRYLLAAGRDPVRQKWLEMIPKNKNDKDNRQFFQASEYAVMLTYLESSERLQLIEEITKWYYSNLAALTEYIGQLSFKNYVKLFFTFDSSAPTLACERMYAFEYVLYTIPKIFNSNDYNQLVAGELVGLPNIDMTMNSKKPFLEHKTMGSQAPERVTLQQATLAKQTTEWLAAAKPPYATNKIGYESGFIPPTGYVPPEGTFHVYMDGKYNELYGFENVPFPPTTTVQVEWLNILQLKDPAGDEKYYGTIQDAEALQKTISSRFFRGRMNNSFIFNEPDVKAGEFTALMAALYLQSRQAFHDWFYKGTTISLQGIFAKVTLRLLVEQLVHVETSRMAELGDAFNLRLSIQMAIDDKGGKVMADRIKGTMEALRNKLVSEELAVCANDEEFYFMAGQLAHYLISQSRAQKITGEMYEPFLRAKNGHQLKKRLEEAYMLYKHEIFSGYHRFNQAFSLVLGYVPETDNQGSARELLLAGIFAYNLLFEKTVKGVE
>NZ_CP036259.1|WP_144351762.1|3970592_3971543_-|type-I-CRISPR-associated-protein-Cas7
MIKMKQRVIGLIGIVSRMANWNADFTGLPKTTSDGNIFGSDKALKYSIKRLWELNGEKVLYIRSYKLGKGKEGEKLQPRDLQERYQQLFGESVAKDSTIVLKRLFACVDVMNFGATFAVEGQNIGLTGAVQIGQGFNKYEETNVEVQDILSPFRNSNEKSLDKDATSIGKKIMVDEAHYIYPFTVSPNHYESYIGLPGLDEFQGYTQEAYAAFKEGALLGATALQTNSKSGSENAFSLFIVLKENALAYLPNLDPYVTVCKKEDKTMYDLSAIAPIVAGIQEQVEQIELYINPYAAEVLLELDGLKRYNIITRAAL
>NZ_CP036259.1|WP_144351761.1|3969792_3970590_-|type-I-B-CRISPR-associated-protein-Cas5
MRALRFELKGETAFFKKPDVNSYAYFTYSHIHKIALFGLLGAILGHGGYMQQYDANYPLTTNRKQAKEVQVFPEFYEVFQQARISIVPHGDRGYFAKKLQIFNNTVGYASQEEGKVLNVREQWLEKPHWTIYVADDAGLAAGIFKKLAESLLQSQSVYMPYLGKNDHPAAITEPALVELSQAGQVKFIDSLHRSDALAYKVRGEIKPGQGKSFFKELMPVALNAENNGYVFHSLVVTNHEIDQASISEDDYRNLYCDGERVLYFI
>NZ_CP036259.1|WP_144351760.1|3967073_3969734_-|CRISPR-associated-helicase-Cas3'
MGIGDYLIDGAEILLAHTAKKGTGKQAESLVEHSDLVLHYVDELSEHNGLSSAIQRTVANLTVQDEPLPLAAQYWIVKCFRQAIYLHDLGKINPVFQKKKMGNQQIEKLSLPGDSNHALLSALLYLDIYLAELDEIEFPGDNALIGSFMKHVLYVFAYVISRHHTYLANAEDADGEETSFEKQLQLLQKKIQRYPGYVHYYRYKERVCSRDSAGRRDITGELLKNRYQRFTDTHSPFPFYVLTKLLYSTMAACDFYATYAYDAEKSLEFQYFSKKQELRPVLETFYNTAIYRGVQALRNNPQTTTLSSINRLRSALFLDTETELLRNLDKQLYYLEAPTGSGKTYMSINLGLKLLNSELGLNKLIYVFPFNALIEQTKLILDKIFPDELRNQYPMPVINSITPIISKKEETAETGNGETEPDFDYKSVLLQRQMLQYPVMLTSHVNFFNYLFGLGRESNLAFTHLCNSVVILDEIQSYKNAIWKEIIHFLQSFAKLLNMKVIIMSATLPNWDSLVEGESDTCSLVAKRELYFQHPLFCKRVQLHFELLQKKVITEEELLAEVLQRLKERRDQGKSTRLLIEFITKAAARSFYRCLQSAKLDSPLFELTGDDSNLLRKEVLKQLGKDEKGIFHLPDVIVVATQVIEAGVDIDMDIGFKDSSMLDSEEQFLGRINRSCLRPDCHAYFFNMVKTTLIYRDDQRTAYDLQTESCQKMLQDKDFSGFYRLVTARINAERQKANLKNWSYFTASVQQLQFKEVEAAMRLITEKQYTLFIAHEAAYKNTDGKEERLDGAQVWEEFKILLADRETEYAERIVKLSQIKEKMAYFTFNYGIQHSCKQTPPQIYTEVAGTLYYIPNGERFMELDENTGAKKFNRQAYIDAGVSPLL
>NZ_CP036259.1|WP_144351759.1|3966582_3967077_-|CRISPR-associated-protein-Cas4
MRITGTIVNYYIHCKRQCWLFAHKMNFEDDSEDVRTGRILHEIRSEGRNNTEIQIEGIKVDKMTEEYVVELKKSDADVEATKWQTLYYLYILKQKGLDRKGRLEFIERNKQNHRTVELELDKRTEPELIRLLDDIEVYLQQDKPVPAIYAKKCERCAYYAYCYI
>NZ_CP036259.1|WP_144351758.1|3965558_3966569_-|type-I-B-CRISPR-associated-endonuclease-Cas1
MAKSAPTTRYIRTPGTLGREDNSLTFRNEKGITHIPINSLKELYLLNEISLNSKLFTFLSMANITVHFFDYYGQFRGTFYPKEARVSGKVMLLQAKACLENRLPIAVAFVGAIAANIHEVLYHYFKHGNKEIKPYLDWLKKEVPDLLPKIKKVPTLLSLEGEIWRRFYETFQLILPEDFVMNHRVKRPPDNPINALVSFGNTILYTKTISQIYHTHLDQTISFLHEPSDRRFSLSLDLSEAFKPLIVFRTIFEVVNNRRIQVSKHFDKKYNYCLLNEPGRDVFITAMEERLQQVFDHGTMKRKISYLTAIKYDAYKLKKHVVEGTPFTPFLEKDRR
>NZ_CP036259.1|WP_144351757.1|3965268_3965550_-|CRISPR-associated-endonuclease-Cas2
MEKNYNYVILVYDIGEKRVGKVFKICKKYLVPFQKSVFRGEITPANLIKLRSELQKVIDKKVDFVALFKMTGDYVFDEEVIGVRLHNQEAMLL
>NZ_CP036259.1|WP_144351756.1|3964157_3964412_-|hypothetical-protein
MALLFQLGPNQLGALTAILAILWAEDLDLDELNSLGNFFEALGSVMLAIAAQKQLLQQHQAEKQTPPESEQIQELIRRIQKLES
>NZ_CP036259.1|WP_144351766.1|3977963_3978515_-|hypothetical-protein
MNKKKSTKIKIAVAVIVCTVIALVLIFNSAFGSMFSFIGNQYRNWEIGRLATTDLSNITVDTIRIGSNLEDVDLAAYQASNRFRNSGGDHAYYFDELILDVDDNKVSYIFAFDEDVLLNINGNKDISTIEEISGLLGENYLAKTEDREQRLIKHIYYDKEIRVVAEIVYSDYDGEFVWIALWR
>NZ_CP036259.1|WP_144351767.1|3978941_3980192_+|FAD-dependent-oxidoreductase
MQEQPKTKHIVIIGAGFGGIRAVRALSKADVRITLIDKHNYHLFQPLLYQVSTATLSIDDIAYPVRAMIKQQKNVHFRMGEVNTIDFERKSVILATAAVAYDYLIIATGGVTNYFGLKAVEKNSFGMKNLDESVTIRNHILHQFELAAYEQDRDKRRARLTFIIVGGGPTGVESAGALSELIYLVMAREYHTLNFKEVRIVLVEASDKVLAAMPAELQETTVETLIRKHVEVRLCVQVTDYDGERLSLKGGEVIPTRTVIWAAGIKAAPLLDTLHIEQDQARRAVVNEFLQLPAHPDVFVIGDAAHYEYAGRPLPMIAPVAIQQADVAAKNIKQLMAEKPLEKFTYKDVGSMATIGRNAAVVHMGHLKLKGVAAWLIWSLVHILRLIDFRNRFVVFMKWVWEYMFYDRLVRIITRQ
>NZ_CP036259.1|WP_144351768.1|3980525_3982763_-|TonB-dependent-siderophore-receptor
MKNNLSLARKRLLYALIGSSLFWHTPAIASAEDTAGAVTATGQTDPQAASAAETTAGKREFTLEMIEVTAMRSRDLPSVYAGGQVARGARLGLLGNVDIMNAPFSITSYTAQMIENRQARTISEVLSNDASVRDATSNGHTIENFRIRGFTVNSYDLGFDGMFGLAPISHVPTEFLERVELLRGPSALLYGMPPNGSLGGTINLVPKRAAEEPLTRFTMDYTSDSQLGAHLDIGRRFGQNNEWGIRVNGVYRDGDTDISGQSKKRELGAVGLDYRGERWRASLDAYYSKENSSGGTLADYYFNTDITSVPSAPDPSTNLFAGTWGWIENKGVAARGEYDINDKLTAYAGLGTANYDFSGYMMSTHAKGIDALGNYSAVTTYTTGYTDIVSAEAGLRGRFQTGAVSHQVVLSATSLSLERGQVFKEGAAYPSNIYNPATLVFAADPGSPSKVAESDLTGVALTDTLSFSQDKYRLTLGVRNQRVNTKNFNSSTGAITARYDKSAVTPAIALVVKPWAAPVSLYANYIEGLSSGSTVTDTTASNYGHVFAPFKTKQIETGVKWDAGDYAHTLSLFQITRPSVIADRSTSVTTYKQDGEQRNRGVEWNVFGQINRDWRILGGVSFLRGVTTHTANGTYDGNTAFGTPKWQSNLGFEWDAPNVSGLTLSTRAVYTGPQYSNSANTMQIPSWIRYDVGARYVTKVNGQPVAFRFTVENVLDKNYWSGCFSDGYLTLGSGRTFKLSTTIDL
>NZ_CP036259.1|WP_144351769.1|3983181_3983997_+|helix-turn-helix-domain-containing-protein
MKVDINDLSGYFAKINFSIVDIRRAVIEPGSKLFGITTSPFPGMIFPLRGRSRMSFDGVPYDMEPGKVFHGGPSMPLDKEVLGQSNWDYMVVHYQVHGNTRGTFPYALSHYELSPGYNPRINDTLHRMYHICKTPGNLPALKIKSLFFIILDEILTFVNCNDSRELVAEAAEYMKNYHMEPLTIPELARQYDLTSKQFAYLFQKHTGMSPNKFLIEYRMRRAKELLCTTTFSVAKIAEYVGYSDPYYFSLLFKKRMGLSPSTLQAFKKIKI
>NZ_CP036259.1|WP_144351770.1|3984294_3985833_-|PAS-domain-containing-protein
MIRKYRSVNALLKENKQLRQQLAEARRILDAIKPGDIDALLVAEAAGGQDYILKGANHIYRVLVEEMQEGCATIAANGTILFCNKNFADIVKTPFEKVIGLSIYNFLKPKDREAFAFFISTRTGRFYTECSFEINDKFCASVILSASNIAIGGDTLTCLVITDLTEQRRSERFTQMIFNQAKEPIIACDKNGQIIQANPAAVAMVGGQLVGHDFDRVIPLFREDNGVRIGLNQAADSSLSCGIEVKYERQDGKAFNLLINAGQFNANEADDNLIGYVVTLTDITDQCLLVHEMTRLDRLNLVGEMAAGIGHEVRNPMTTVRGYLQLFQRKEKYADDHEQLMVMIEELDRANLIITEFLSLAKNKRIEPKPGNLNGTIHALFPLLQADAFRFGHEIEADIGDIPPTCYDDKEIRQLILNLVRNAMEAMDSRGSVTIRTYADNQAITLAVQDTGPGIPENILPKIGTPFLTTKEGGTGLGLSVCYRIAESHGARIEVETSSRGTTFFVRFKVVE
>NZ_CP036259.1|WP_170233324.1|3986406_3986574_-|hypothetical-protein
MTRNCLSQISKILIGVFYRATRRAFENSLPPLAGTTLVGQPLATVEVSLLMDELA
>NZ_CP036259.1|WP_144351771.1|3986545_3988795_-|heavy-metal-translocating-P-type-ATPase
MSTGPLHIVHKLPGRIRLYCPQLRCNPGFGLQIEAFLQQQPGIKEYRANPKSGRILILYDRTRLSEQMVCLLLRQYDYAGTSPPKADLDKKNSEKSKPFELEDMAIPTQIGLVALGGVTLLYYVVKYFCRYSPISIGMERIASLITLITALPILRSGLESIILQRKLNNEILIGAATLLSLLLREGATGLVVVWLVNLSTLIETLTLDRSRRTIRTMLEGDQKSAWIVVNGQELSIPITQLQQADTVSVKLGSKIPVDGTVVEGAAVVNQAALTGEPIPVYKHPGDQVLAGSTIEQGTLYIRAERVGDQTSVARIIHLVEQATHSKAPIQRLADQYSARIIPASFLLAFIVFLLTRDIRRTMTILIVACPCAAGLATPTALSAAIGNAAGRGILVKGGRYLEEAGKVDFLLFDKTGTLTEGKPAVVEVIPVHQKYDTAAILTLAAAAEANANHPLANAIKEAAEKQGITLPVIPNSEMTVGGGVRAMINGKAIHVGNSRYLTEMGVKLSPRIPALIRDFAESSTLVYVGSGTQVVGVIVIQDAVRPNAVKAICDLRAEGIINIGIVSGDTEAVVQATANQLGVETVWSTMLPQDKFELVKSLKARGHVVGMVGDGINDSPSLALADVGVAMGVGGADAAIETAGIVLREDNPEKIVEVIRLGKQSLIVIRQNFLFAIGANILGLGLGSAKLISPFLAAILHNASTLAVVLNSTRLLSYAPAQLSKPRTLSPAACDQYTLAYDPELPEPD
>NZ_CP036259.1|WP_144351772.1|3988944_3989571_-|hypothetical-protein
MSACVQPIDSLLAECKRDIRWEFHQIYLRIRPEEVQRLAEGLLHKTPPEWPRALYELQKGKLHSRLLKHLNFHLRRQGFPAETELVFRGPFPSFSLRPLQAVIEEHRTTLRMAGCIEFLGNKIWDHALKPVRKRLMPVHVHVATWALDACGCSAKQQWSVVLADLTQRIRGSIINFLFACEALLIEQVQEQLLLYKTNLPLPISEAAV
>NZ_CP036259.1|WP_144351773.1|3989864_3990632_+|hypothetical-protein
MHFRYHRFQKTLFFGEKIFINRHKVKLLAAAAKERKKEWPAVNTVLTCSQFVNQLLSNSLAVARTNLRPFINDVISGAEPFNSESFYRRIVSRDELQRLHLQISRHLSTALLLPVEHCSTVLKGSCQDPVSFLSSTGLIEQYKSTVAITKGIALVAEAIYDQSLAQLQPHWIIKKLINKLNVSTALLAATDCHPVNHEKRCLAEIESCLAGSIESFYHQLRHHYLSKTATLIYSFHDAHRQMPPRHLYLVKKPSQ
>NZ_CP036259.1|WP_144351774.1|3990934_3991888_+|DUF362-domain-containing-protein
MERRQFISGLGYGLLSLGLAGCGLRFSGKSADPEEKRGATDNKQTAAPAAGVYDRGKLIVAEGTDPNSLIEKGFKALGGIAALVRSGATVVIKPNFSVPRKPEEAATTNPLLVAAVVKQCLAAGAKTVKVIDYPFSSPPVCLVNSGIKAAVEAAGGRAFAINAPNFYTQVDMGGKILKDVLFSKDVLEADVFINFPILKHHNATKLTLGLKNMMGLVWDRGYFHRTDLLQGIAELAAFRRPHLTILDATKGITGNGPVGPGPIRAWNQVVFGVDPVAVDAYGATLFGLKPAEIGYVPLAAQLGAGELELQKLTVVKV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP036259_12	12.1\|3413239\|35\|NZ_CP036259\|CRISPRCasFinder	3413239-3413273	35	NZ_CP036259.1	1516641-1516675	0	1.0

1. spacer 12.1|3413239|35|NZ_CP036259|CRISPRCasFinder matches to position: 1516641-1516675, mismatch: 0, identity: 1.0

gggtatgccaaacgggcgcagacggcacgggcaac	CRISPR spacer
gggtatgccaaacgggcgcagacggcacgggcaac	Protospacer
***********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	NZ_CP039697	Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence	50469-50498	6	0.8
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	740972-741001	6	0.8
NZ_CP036259_15	15.2\|3976379\|35\|NZ_CP036259\|CRT,PILER-CR,CRISPRCasFinder	3976379-3976413	35	KR093636	Moraxella phage Mcat12, complete genome	10123-10157	6	0.829
NZ_CP036259_15	15.2\|3976379\|35\|NZ_CP036259\|CRT,PILER-CR,CRISPRCasFinder	3976379-3976413	35	KR093635	Moraxella phage Mcat11, complete genome	8362-8396	6	0.829
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	NZ_CP049249	Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed3, complete sequence	265460-265489	7	0.767
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	CP053403	Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence	22520-22549	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	CP053403	Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence	22916-22945	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	CP053403	Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence	23312-23341	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	CP053403	Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence	23708-23737	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	NZ_CP019182	Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence	4000-4029	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	NZ_CP019182	Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence	4396-4425	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	NZ_CP019182	Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence	4792-4821	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	NZ_CP019182	Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence	5188-5217	8	0.733
NZ_CP036259_8	8.1\|1748011\|30\|NZ_CP036259\|CRISPRCasFinder	1748011-1748040	30	MK942064	Caulobacter phage Jess A, complete genome	13265-13294	8	0.733
NZ_CP036259_13	13.12\|3888195\|33\|NZ_CP036259\|PILER-CR,CRISPRCasFinder,CRT	3888195-3888227	33	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1054576-1054608	9	0.727
NZ_CP036259_13	13.15\|3888392\|33\|NZ_CP036259\|PILER-CR,CRISPRCasFinder,CRT	3888392-3888424	33	NZ_CP019637	Nostocales cyanobacterium HT-58-2 plasmid pHT582-1, complete sequence	6356-6388	9	0.727
NZ_CP036259_13	13.16\|3888457\|33\|NZ_CP036259\|PILER-CR,CRISPRCasFinder,CRT	3888457-3888489	33	NZ_CP031166	Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence	317909-317941	9	0.727
NZ_CP036259_13	13.12\|3888195\|33\|NZ_CP036259\|PILER-CR,CRISPRCasFinder,CRT	3888195-3888227	33	CP006583	Mesorhizobium huakuii 7653R plasmid pMHb, complete sequence	124823-124855	10	0.697
NZ_CP036259_6	6.3\|185144\|34\|NZ_CP036259\|CRISPRCasFinder	185144-185177	34	NZ_CP049029	Fluviibacterium aquatile strain SC52 plasmid pSC52_1, complete sequence	212260-212293	11	0.676
NZ_CP036259_13	13.12\|3888195\|33\|NZ_CP036259\|PILER-CR,CRISPRCasFinder,CRT	3888195-3888227	33	NZ_CP041206	Rhizobium sp. NIBRBAC000502774 plasmid pMK-3, complete sequence	91488-91520	11	0.667

1. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to NZ_CP039697 (Novosphingobium sp. ABRDHK2 plasmid pABRDHK22, complete sequence) position: , mismatch: 6, identity: 0.8

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
ggcggtaccgtcgtcaatggcggtacgctg	Protospacer
* **.******************.*  .**

2. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 6, identity: 0.8

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gccgataccgacgacaatggcggcaccctg	Protospacer
*.******** ** *********** ..**

3. spacer 15.2|3976379|35|NZ_CP036259|CRT,PILER-CR,CRISPRCasFinder matches to KR093636 (Moraxella phage Mcat12, complete genome) position: , mismatch: 6, identity: 0.829

ttataaacataagcattgccccacggatcaacaat	CRISPR spacer
atgtacacataagcattgccccacagatcaagact	Protospacer
 *.** ******************.****** * *

4. spacer 15.2|3976379|35|NZ_CP036259|CRT,PILER-CR,CRISPRCasFinder matches to KR093635 (Moraxella phage Mcat11, complete genome) position: , mismatch: 6, identity: 0.829

ttataaacataagcattgccccacggatcaacaat	CRISPR spacer
atgtacacataagcattgccccacagatcaagact	Protospacer
 *.** ******************.****** * *

5. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to NZ_CP049249 (Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.767

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gatgtcaccgtcgtcactggcggcagtatc	Protospacer
* .* .********** ********** *

6. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to CP053403 (Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

7. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to CP053403 (Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

8. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to CP053403 (Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

9. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to CP053403 (Salmonella enterica strain 2010K-2057 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

10. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to NZ_CP019182 (Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

11. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to NZ_CP019182 (Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

12. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to NZ_CP019182 (Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

13. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to NZ_CP019182 (Salmonella enterica subsp. enterica serovar Inverness str. ATCC 10720 plasmid pATCC10720, complete sequence) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
gtcggtgccgtcgtcaatggcggggtacag	Protospacer
****.*.**************** .  . *

14. spacer 8.1|1748011|30|NZ_CP036259|CRISPRCasFinder matches to MK942064 (Caulobacter phage Jess A, complete genome) position: , mismatch: 8, identity: 0.733

gtcgataccgtcgtcaatggcggcagtttg	CRISPR spacer
ttcgatagcggcgtcaatggcggcctggtc	Protospacer
 ****** ** *************    *

15. spacer 13.12|3888195|33|NZ_CP036259|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 9, identity: 0.727

cgtccacgcagcggatcttcccaatcc---gggcat	CRISPR spacer
tcgccacgcatcggatcttcgcaatcctttgcg---	Protospacer
.  ******* ********* ******   * *

16. spacer 13.15|3888392|33|NZ_CP036259|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019637 (Nostocales cyanobacterium HT-58-2 plasmid pHT582-1, complete sequence) position: , mismatch: 9, identity: 0.727

ttaacccaatagcatcagctaattgtgctatag	CRISPR spacer
atgcagcaatagcatccgttaattgtgctattc	Protospacer
 *.   ********** *.************

17. spacer 13.16|3888457|33|NZ_CP036259|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP031166 (Euzebya sp. DY32-46 plasmid pEDY32-46I, complete sequence) position: , mismatch: 9, identity: 0.727

agatacccgccatgccggcagttgccttggcaa	CRISPR spacer
tcgtggccgccatgccggcggttgccgtggccg	Protospacer
  .*. *************.****** **** .

18. spacer 13.12|3888195|33|NZ_CP036259|PILER-CR,CRISPRCasFinder,CRT matches to CP006583 (Mesorhizobium huakuii 7653R plasmid pMHb, complete sequence) position: , mismatch: 10, identity: 0.697

cgtccacgcagcggatcttcccaatccgggcat	CRISPR spacer
ggcaagggcagcggattttcccgatccgggcga	Protospacer
 *.  . *********.*****.********.

19. spacer 6.3|185144|34|NZ_CP036259|CRISPRCasFinder matches to NZ_CP049029 (Fluviibacterium aquatile strain SC52 plasmid pSC52_1, complete sequence) position: , mismatch: 11, identity: 0.676

tagtaaggaaaaggccgggaagatcaaagctctg	CRISPR spacer
gtgccaggaaaaggccgagtagatcaaagacgac	Protospacer
  *. ************.* ********* .

20. spacer 13.12|3888195|33|NZ_CP036259|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041206 (Rhizobium sp. NIBRBAC000502774 plasmid pMK-3, complete sequence) position: , mismatch: 11, identity: 0.667

cgtccacgcagcggatcttcccaatccgggcat	CRISPR spacer
atctcacgcagcgcatcttcccgatccgtctcc	Protospacer
  ..********* ********.*****  . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1098044 : 1105588

Synechococcus_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144349305.1\|1098044_1099415_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	7.8e-62	34.6
WP_144349306.1\|1099536_1100034_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.8e-22	42.8
WP_144349307.1\|1100180_1100894_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3HI61	Synechococcus_phage	7.4e-40	39.7
WP_144349308.1\|1100893_1102330_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.5e-66	36.0
WP_144349309.1\|1102345_1103398_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SQF5	Cyanophage	5.0e-69	42.6
WP_144349310.1\|1103409_1104027_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.2e-23	39.1
WP_144349311.1\|1104046_1105588_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	1.4e-72	50.2

DBSCAN-SWA_2

1396494 : 1421194

Acinetobacter_phage(100.0%)

transposase,protease,coat

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_170233173.1\|1396494_1396941_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	3.2e-25	44.8
WP_170233174.1\|1397142_1397361_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.8e-13	46.6
WP_144349512.1\|1399618_1399927_+	hypothetical protein	NA	NA	NA	NA
WP_144349513.1\|1400252_1401815_-\|transposase	IS1182 family transposase	NA	NA	NA	NA
WP_170233175.1\|1401998_1402145_-	hypothetical protein	NA	NA	NA	NA
WP_144352775.1\|1402290_1402542_+	hypothetical protein	NA	NA	NA	NA
WP_144349514.1\|1402542_1402845_+\|coat	spore coat protein	NA	NA	NA	NA
WP_144349515.1\|1403352_1404003_+	hypothetical protein	NA	NA	NA	NA
WP_144349516.1\|1404139_1404997_+	DUF3307 domain-containing protein	NA	NA	NA	NA
WP_144349517.1\|1405588_1406074_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_144349518.1\|1406272_1406932_+	hypothetical protein	NA	NA	NA	NA
WP_144349519.1\|1406993_1407833_-\|protease	site-2 protease family protein	NA	NA	NA	NA
WP_144349520.1\|1408467_1409940_+	TIGR02677 family protein	NA	NA	NA	NA
WP_144349521.1\|1409963_1411175_+	TIGR02678 family protein	NA	NA	NA	NA
WP_144349522.1\|1411167_1415346_+	TIGR02680 family protein	NA	NA	NA	NA
WP_144349523.1\|1415345_1416728_+	TIGR02679 family protein	NA	NA	NA	NA
WP_144349524.1\|1417394_1418033_+	EF-hand domain-containing protein	NA	NA	NA	NA
WP_144352776.1\|1418591_1419539_+	tripartite tricarboxylate transporter substrate binding protein	NA	NA	NA	NA
WP_144349525.1\|1419634_1421194_-\|transposase	IS1182 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

1672466 : 1680124

Bacillus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144349751.1\|1672466_1673426_+	glycosyltransferase	F1C5B0	Cronobacter_phage	4.6e-61	42.2
WP_144349752.1\|1673665_1674334_+	C40 family peptidase	A0A142F1E9	Bacillus_phage	1.8e-08	35.5
WP_170233188.1\|1674451_1676176_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	6.8e-63	30.2
WP_144349755.1\|1676376_1677108_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	4.2e-14	30.5
WP_144349757.1\|1677122_1677968_+	metal ABC transporter permease	NA	NA	NA	NA
WP_144349759.1\|1678035_1678605_+	HDIG domain-containing protein	NA	NA	NA	NA
WP_144349760.1\|1678673_1679270_+\|protease	spore protease YyaC	G3M9W0	Bacillus_virus	4.5e-14	35.4
WP_144349761.1\|1679665_1680124_+	sigma-70 family RNA polymerase sigma factor	U5PUF5	Bacillus_phage	3.2e-12	42.7

DBSCAN-SWA_4

1685434 : 1739052

Clostridium_phage(12.5%)

transposase,terminase,tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144349772.1\|1685434_1685662_-	helix-turn-helix domain-containing protein	S5MA03	Brevibacillus_phage	1.6e-09	42.5
WP_170233189.1\|1686201_1686342_+	hypothetical protein	NA	NA	NA	NA
WP_144349775.1\|1686369_1686726_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_144349777.1\|1686825_1687140_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_144349779.1\|1687204_1687435_+	hypothetical protein	NA	NA	NA	NA
WP_144349780.1\|1687379_1688312_+	YqaJ viral recombinase family protein	S6C475	Thermus_phage	1.0e-89	54.8
WP_144352798.1\|1688366_1689212_+	recombinase RecT	Q9T172	Listeria_phage	8.8e-56	50.4
WP_170233190.1\|1689204_1689549_+	hypothetical protein	I3VYX7	Thermoanaerobacterium_phage	8.9e-07	34.1
WP_144349784.1\|1689757_1690000_+	acyl carrier protein	NA	NA	NA	NA
WP_144349785.1\|1689996_1690269_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A0K2CZ86	Paenibacillus_phage	3.2e-20	58.2
WP_144349786.1\|1690337_1691471_+	DNA polymerase III subunit beta	A0A0A8IL17	Aurantimonas_phage	1.2e-23	25.0
WP_144349787.1\|1691478_1692519_+	hypothetical protein	A0A2H4JC51	uncultured_Caudovirales_phage	1.0e-90	48.2
WP_144349789.1\|1692539_1692683_+	DUF4428 domain-containing protein	NA	NA	NA	NA
WP_144349790.1\|1692679_1693291_-	hypothetical protein	NA	NA	NA	NA
WP_144349791.1\|1693408_1694182_+	DnaD domain protein	NA	NA	NA	NA
WP_144349793.1\|1694258_1694774_+	ATP-binding protein	S4U0J1	uncultured_phage	4.1e-32	40.0
WP_144349795.1\|1694795_1695152_+	hypothetical protein	A0A0A7S133	Clostridium_phage	5.0e-05	36.2
WP_144349796.1\|1695154_1695460_+	hypothetical protein	NA	NA	NA	NA
WP_144349798.1\|1695617_1695953_+	hypothetical protein	NA	NA	NA	NA
WP_144349800.1\|1696025_1696481_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_144349801.1\|1696605_1697040_-	type II toxin-antitoxin system HicB family antitoxin	A0A1L2JY34	Aeribacillus_phage	5.2e-36	53.1
WP_144352799.1\|1697066_1697255_-	type II toxin-antitoxin system HicA family toxin	A0A0A7RWW9	Clostridium_phage	1.0e-12	57.4
WP_144349803.1\|1697810_1698101_+	hypothetical protein	NA	NA	NA	NA
WP_144349804.1\|1698138_1699005_+\|terminase	terminase	X5JB33	Clostridium_phage	4.5e-31	45.3
WP_144349805.1\|1698994_1700281_+\|terminase	PBSX family phage terminase large subunit	E5DV50	Deep-sea_thermophilic_phage	2.7e-141	58.8
WP_144349807.1\|1700294_1700543_+	hypothetical protein	NA	NA	NA	NA
WP_144349809.1\|1700558_1702640_+	poly(3-hydroxybutyrate) depolymerase	A0A1B1IQR4	uncultured_Mediterranean_phage	3.0e-49	29.6
WP_170233191.1\|1702632_1702776_+	hypothetical protein	NA	NA	NA	NA
WP_144349811.1\|1702811_1703888_+	hypothetical protein	NA	NA	NA	NA
WP_170233192.1\|1703924_1704887_+	DUF5309 family protein	I2FLT5	Pseudomonas_phage	8.5e-23	29.5
WP_144349814.1\|1704950_1705250_+	hypothetical protein	NA	NA	NA	NA
WP_144349816.1\|1705252_1705798_+	hypothetical protein	NA	NA	NA	NA
WP_144349818.1\|1705813_1706305_+	hypothetical protein	NA	NA	NA	NA
WP_144349819.1\|1706307_1708821_+\|tail	tail fiber domain-containing protein	U5PSK6	Bacillus_phage	1.2e-39	50.6
WP_144349820.1\|1708834_1709518_+	hypothetical protein	NA	NA	NA	NA
WP_144349821.1\|1709533_1710982_+	hypothetical protein	NA	NA	NA	NA
WP_144349823.1\|1710984_1712043_+	hypothetical protein	A0A1V0DY51	Dinoroseobacter_phage	1.1e-12	47.3
WP_170233193.1\|1712035_1712734_+	collagen-like protein	A0A1D8KSC4	Synechococcus_phage	9.6e-08	53.8
WP_144349824.1\|1712739_1713693_+	hypothetical protein	NA	NA	NA	NA
WP_144349826.1\|1713706_1714414_+	hypothetical protein	NA	NA	NA	NA
WP_144349828.1\|1714456_1714765_+	hypothetical protein	NA	NA	NA	NA
WP_170233194.1\|1714754_1715444_+	hypothetical protein	NA	NA	NA	NA
WP_144349832.1\|1715444_1715765_+	hypothetical protein	NA	NA	NA	NA
WP_144349833.1\|1715764_1716346_+	hypothetical protein	NA	NA	NA	NA
WP_144349835.1\|1716359_1717889_+	hypothetical protein	NA	NA	NA	NA
WP_144349836.1\|1717898_1726067_+	glucosaminidase domain-containing protein	Q08J70	Stx2-converting_phage	4.0e-20	43.4
WP_144349837.1\|1726146_1726740_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_144349839.1\|1726811_1727375_+	glycosyl hydrolase family 25	NA	NA	NA	NA
WP_144349841.1\|1727468_1727897_+	hypothetical protein	NA	NA	NA	NA
WP_170233195.1\|1728175_1729045_+	hypothetical protein	A3QSC6	Clostridium_virus	5.8e-55	41.2
WP_144349844.1\|1729226_1729472_+	hypothetical protein	NA	NA	NA	NA
WP_144349846.1\|1729524_1730154_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_144349847.1\|1730265_1730517_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_144349849.1\|1730524_1731412_+	DUF3102 domain-containing protein	A0A2H4J025	uncultured_Caudovirales_phage	2.6e-26	50.4
WP_144349851.1\|1731404_1731782_+	ORF6C domain-containing protein	A0A0S2MVD8	Bacillus_phage	9.1e-05	23.7
WP_144349852.1\|1731783_1732002_+	helix-turn-helix domain-containing protein	D7RWM4	Brochothrix_phage	1.1e-13	54.7
WP_144349853.1\|1732355_1735013_+\|tail	tail fiber domain-containing protein	U5PSK6	Bacillus_phage	3.3e-48	57.1
WP_144349855.1\|1735107_1736649_-	hypothetical protein	NA	NA	NA	NA
WP_144349856.1\|1736658_1737147_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_144349858.1\|1737130_1737808_-	hypothetical protein	NA	NA	NA	NA
WP_144349864.1\|1737982_1738264_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_144349866.1\|1738542_1738764_+	hypothetical protein	NA	NA	NA	NA
WP_144349868.1\|1738845_1739052_+\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_5

2841088 : 2854559

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144350859.1\|2841088_2841979_-	amidoligase family protein	A0A2K9V489	Faecalibacterium_phage	1.5e-61	44.1
WP_144350860.1\|2842165_2842999_-	hypothetical protein	A0A2K5B280	Erysipelothrix_phage	8.7e-16	28.4
WP_144350861.1\|2843061_2844048_-	DNA (cytosine-5-)-methyltransferase	A0A1X9I6A7	Streptococcus_phage	3.0e-100	46.2
WP_144350862.1\|2844044_2845322_-	ParB N-terminal domain-containing protein	A0A1B0RXJ0	Streptococcus_phage	7.6e-120	51.4
WP_144350863.1\|2845889_2846303_-	hypothetical protein	E5DV97	Deep-sea_thermophilic_phage	4.3e-16	34.8
WP_170233267.1\|2846303_2846555_-	DUF3310 domain-containing protein	NA	NA	NA	NA
WP_144350865.1\|2847121_2848993_-	bifunctional DNA primase/polymerase	A0A2H4J1M0	uncultured_Caudovirales_phage	2.8e-163	46.9
WP_144350866.1\|2848989_2850678_-	hypothetical protein	A0A2H4J041	uncultured_Caudovirales_phage	1.8e-185	55.7
WP_144350867.1\|2850674_2851133_-	DUF669 domain-containing protein	A0A2H4J1S8	uncultured_Caudovirales_phage	3.0e-34	52.0
WP_170233268.1\|2851158_2852766_-	AAA family ATPase	A0A2H4J7Q2	uncultured_Caudovirales_phage	1.1e-144	51.0
WP_144350869.1\|2852755_2853043_-	VRR-NUC domain-containing protein	A0A2H4J095	uncultured_Caudovirales_phage	1.6e-14	43.8
WP_144350870.1\|2853039_2854224_-	DEAD/DEAH box helicase	A0A2H4J064	uncultured_Caudovirales_phage	5.6e-141	61.9
WP_144350871.1\|2854220_2854559_-	DUF4406 domain-containing protein	A0A2K5B270	Erysipelothrix_phage	3.3e-22	46.1

DBSCAN-SWA_6

5049185 : 5059169

Streptococcus_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144352565.1\|5049185_5050214_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	6.8e-10	31.4
WP_144352566.1\|5050185_5050995_+	stage 0 sporulation family protein	NA	NA	NA	NA
WP_144352567.1\|5050994_5051744_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_144353056.1\|5051815_5052616_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	4.3e-52	45.9
WP_144352568.1\|5052622_5052871_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A2I7SC16	Paenibacillus_phage	7.8e-21	59.8
WP_144352569.1\|5053157_5055092_+\|tRNA	methionine--tRNA ligase	A0A1V0SEZ7	Hokovirus	4.0e-104	35.2
WP_144352570.1\|5055093_5055861_+	YchF/TatD family DNA exonuclease	NA	NA	NA	NA
WP_144353057.1\|5056104_5057082_+	G5 domain-containing protein	L0LBX4	Bacillus_phage	8.7e-15	51.7
WP_144353058.1\|5057444_5059169_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.8e-07	26.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP036260

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP036259

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection