CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP036274	Planctomycetes bacterium ETA_A8 chromosome, complete genome	5 crisprs	WYL,RT,csa3,cas3,Cas9_archaeal	2	2	1	0

1. NZ_CP036274

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP036274_1

• CRISPR_ID: NZ_CP036274_1
• CRISPR_location: 26006-26077
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP036274_1

Consensus_repeat	Method
GCGCGGCGTGAATAAGCCGCTGC	CRISPRCasFinder

spacers of NZ_CP036274_1

>1.1|26029|26|NZ_CP036274|CRISPRCasFinder
TGATGCTTCGCACTGCTACGCTTCGG

CRISPR arrays and Neighbor proteins around NZ_CP036274_1

CRISPR arrays

The CRISPR arrays of NZ_CP036274_1

>merge|NZ_CP036274|1|26006-26077|CRISPRCasFinder
GCGCGGCGTGAATAAGCCGCTGCTGATGCTTCGCACTGCTACGCTTCGGCAGCGGCGTGAATAAGCCGCTGC

>NZ_CP036274|1|1|26006-26077|CRISPRCasFinder
GCGCGGCGTGAATAAGCCGCTGC	TGATGCTTCGCACTGCTACGCTTCGG
CAGCGGCGTGAATAAGCCGCTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036274.1|WP_145083091.1|26308_27634_-|DUF2130-domain-containing-protein	unknown	unknown	gnl|CDD|370744
NZ_CP036274.1|WP_145083088.1|25596_25893_-|transposase	unknown	unknown	gnl|CDD|372671
NZ_CP036274.1|WP_145083076.1|19143_20196_+|sialate-O-acetylesterase	unknown	unknown	gnl|CDD|377084
NZ_CP036274.1|WP_145083106.1|32901_33783_-|M15-family-metallopeptidase	unknown	unknown	gnl|CDD|350618
NZ_CP036274.1|WP_145083082.1|21192_23799_+|DUF1592-domain-containing-protein	unknown	unknown	gnl|CDD|377886
NZ_CP036274.1|WP_145083079.1|20232_20925_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238141
NZ_CP036274.1|WP_145083073.1|17902_18709_-|hypothetical-protein	unknown	unknown	gnl|CDD|274290
NZ_CP036274.1|WP_145083085.1|23849_25163_+|DUF1552-domain-containing-protein	unknown	unknown	gnl|CDD|377875
NZ_CP036274.1|WP_145083070.1|17061_17919_-|hypothetical-protein	unknown	unknown	gnl|CDD|378037
NZ_CP036274.1|WP_145083064.1|14067_15126_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|377533
NZ_CP036274.1|WP_145083097.1|29152_29416_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145083109.1|33814_35128_-|hypothetical-protein	unknown	unknown	gnl|CDD|368090
NZ_CP036274.1|WP_145083116.1|37219_38527_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145083067.1|15157_17167_-|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl|CDD|366234
NZ_CP036274.1|WP_145083113.1|35236_37039_-|CocE/NonD-family-hydrolase	unknown	unknown	gnl|CDD|225487
NZ_CP036274.1|WP_145083061.1|12147_14067_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|377670
NZ_CP036274.1|WP_145083100.1|29412_30765_-|hypothetical-protein	unknown	unknown	gnl|CDD|368090
NZ_CP036274.1|WP_145083103.1|30997_32749_-|hypothetical-protein	unknown	unknown	gnl|CDD|379468
NZ_CP036274.1|WP_145083094.1|27749_28634_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145083119.1|38747_39443_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238141

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP036274.1|WP_145083091.1|26308_27634_-|DUF2130-domain-containing-protein	gnl|CDD|370744	pfam09903, DUF2130, Uncharacterized protein conserved in bacteria (DUF2130). This domain, found in various hypothetical prokaryotic proteins, has no known function.	1.77845e-64
NZ_CP036274.1|WP_145083088.1|25596_25893_-|transposase	gnl|CDD|372671	pfam13683, rve_3, Integrase core domain.	2.76141e-05
NZ_CP036274.1|WP_145083076.1|19143_20196_+|sialate-O-acetylesterase	gnl|CDD|377084	pfam03629, SASA, Carbohydrate esterase, sialic acid-specific acetylesterase. The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.	3.57125e-17
NZ_CP036274.1|WP_145083082.1|21192_23799_+|DUF1592-domain-containing-protein	gnl|CDD|377886	pfam07631, PSD4, Protein of unknown function (DUF1592). A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match pfam07627, pfam07626, and pfam07624.	8.71294e-48
NZ_CP036274.1|WP_145083079.1|20232_20925_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238141	cd00229, SGNH_hydrolase, SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.	1.47299e-15
NZ_CP036274.1|WP_145083073.1|17902_18709_-|hypothetical-protein	gnl|CDD|274290	TIGR02772, conserved_hypothetical_protein, Ku protein, prokaryotic. Members of this protein family are Ku proteins of non-homologous end joining (NHEJ) DNA repair in bacteria and in at least one member of the archaea (Archaeoglobus fulgidus). Most members are encoded by a gene adjacent to the gene for the DNA ligase that completes the repair. The NHEJ system is broadly but rather sparsely distributed, being present in about one fifth of the first 250 completed prokarytotic genomes. A few species (e.g. Archaeoglobus fulgidus and Bradyrhizobium japonicum) have multiple copies that appear to represent recent paralogous family expansion. [DNA metabolism, DNA replication, recombination, and repair].	2.2348e-31
NZ_CP036274.1|WP_145083085.1|23849_25163_+|DUF1552-domain-containing-protein	gnl|CDD|377875	pfam07586, HXXSHH, Protein of unknown function (DUF1552). A family of proteins identified in Rhodopirellula baltica.	6.36373e-80
NZ_CP036274.1|WP_145083070.1|17061_17919_-|hypothetical-protein	gnl|CDD|378037	pfam08722, Tn7_Tnp_TnsA_N, TnsA endonuclease N terminal. The Tn7 transposase is composed of proteins TnsA and TnsB. DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.	4.18004e-19
NZ_CP036274.1|WP_145083064.1|14067_15126_-|AAA-family-ATPase	gnl|CDD|377533	pfam05621, TniB, Bacterial TniB protein. This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein which is involved in Tn5053 mercury resistance transposition.	1.70878e-19
NZ_CP036274.1|WP_145083106.1|32901_33783_-|M15-family-metallopeptidase	gnl|CDD|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	7.98289e-13
NZ_CP036274.1|WP_145083109.1|33814_35128_-|hypothetical-protein	gnl|CDD|368090	pfam04734, Ceramidase_alk, Neutral/alkaline non-lysosomal ceramidase, N-terminal. This family represents N-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes. The EC classification is EC:3.5.1.23. The enzyme hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. This N-terminal domain carries two metal-binding sites, the first for Zn2+ residing within the domain, and the second, for Mg2+/Ca2+ lying at the interface between the two domains.	0.000159633
NZ_CP036274.1|WP_145083067.1|15157_17167_-|DDE-type-integrase/transposase/recombinase	gnl|CDD|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.39541e-15
NZ_CP036274.1|WP_145083113.1|35236_37039_-|CocE/NonD-family-hydrolase	gnl|CDD|225487	COG2936, COG2936, Predicted acyl esterases [General function prediction only].	8.2681e-128
NZ_CP036274.1|WP_145083061.1|12147_14067_-|helix-turn-helix-domain-containing-protein	gnl|CDD|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	3.17583e-11
NZ_CP036274.1|WP_145083100.1|29412_30765_-|hypothetical-protein	gnl|CDD|368090	pfam04734, Ceramidase_alk, Neutral/alkaline non-lysosomal ceramidase, N-terminal. This family represents N-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes. The EC classification is EC:3.5.1.23. The enzyme hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. This N-terminal domain carries two metal-binding sites, the first for Zn2+ residing within the domain, and the second, for Mg2+/Ca2+ lying at the interface between the two domains.	1.34541e-07
NZ_CP036274.1|WP_145083103.1|30997_32749_-|hypothetical-protein	gnl|CDD|379468	pfam14100, PmoA, Methane oxygenase PmoA. This family is a putative methane oxygenase.	1.01516e-62
NZ_CP036274.1|WP_145083119.1|38747_39443_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238141	cd00229, SGNH_hydrolase, SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.	8.92354e-09

Protein sequences

>NZ_CP036274.1|WP_145083088.1|25596_25893_-|transposase
MPGRRQEFRRELTSFFDWYNEHRPHTTLQGCTPNEVYHRCFPENRRLRFEPRSNWPRGAPCAKPSSLVKGRPGGKVDLQVAFHAERKHLPIVKLRRAA
>NZ_CP036274.1|WP_145083085.1|23849_25163_+|DUF1552-domain-containing-protein
MKPIPRRLFLKNAGIAIGLPLLDSMLPTGCLGAAPAASPRRIVCIGVPFGFDPTAFVPVAAGRDYVLPSHLAHLAAYRDDFTVISGLSHPNTGGGGHKAEAVMLTGAPYPDYSHNLKNTISVDQAFAAKLRGETRYESFALTTQGQSLSVTANGVSIPAIGSPSAVFKKLFLAATPAEMDAELRRIDEGRSMLDFVSDRAKNLNRQISGADRQRVDEYFESVRDVERQLKMTREWVNRPKPPAIGGEPKDIGDNQQQQAKFRLMIDMIHLALVTDSTRAISLMTFGMHHDLSHHGKEPKKLAACRQVEVELMLAFGGLLGKLKNAKEGGSTLLDSTMVMMTSNLRDGNTHWTYNLPVILAGGGFRHGQHLAFNRSYLDEVSQELKPAPETKIKSEKKIPLMGQDQQPLCNLYTSMLQRGGVEIERFSSATGSLNGLV
>NZ_CP036274.1|WP_145083082.1|21192_23799_+|DUF1592-domain-containing-protein
MKLTLTLFTALPVALLIGLPAAESASADELPLSFIKNHCWECHDETTKEGGFRADLLGKNLGNAASRKAWSRVLARVQSGEMPPPEETERPAESAVIASLEALKAAFHEETQARHVEAGRVRVRRLNRLEYENTVRDLLGIDTSLRDLLPEDDLRDGFSNQTAALSISPVHIQQYMAAADRALEAASVRQSRPETKTHRFAFNHEVEKPWSAYPHNRLQCNLHGEDLHFFLDTHIEVPVALRQFEAVTREAPGRYRIRIMTESRDTTDGEDLIYSVWVAAGGKRKELIGHFDALHRKESVIELTRSFDRGETIIIAPYRMAKVRIDAGYSVYAPDKAEKIPKGWHFLNNPNPPIATVGPAIVVKPVEITGPLIETWPPSGHQLLYGDVAELVPAAEIAKTARVPDSILRPVRAYRPLTDPLTVRLPADKTEEAMREALTQFISRAFRRPATAEEVELYRAMARDRLAKGECLEVALNAAHRAVLCSPEFLFLVEKGPKLNSHELAARLSYFLWRTTPDDGLRKLADKGELTKPAVLRQETARMIASPRFSVFVRDFLSQWLNLREIDATTPDRDLFPEYFENIHDGRQDVLLHDSLVGETRAFFGDLVERDLGVTTLVSAPHAYLNQRLAEHYDLPPVAGAGLRRVDLPADCVRGGLLTQASILKVTANGANTSPVLRGVWLLERIVGTPAPPPPPNAGSIEPDTRGSTTIREQLAKHQSVKTCAGCHQKIDPPGFVLEAFDPIGRYRDYYRTTETGQKIEIKDARAFFGGNYGHVKYLKGATVDTKSRLPGGVEIADVRAYKAALAARPELLARSLARKLVTFATGVSVEVGDELVVDTILEKSQASDFGLRTLIHEVVQSELFIRK
>NZ_CP036274.1|WP_145083079.1|20232_20925_+|SGNH/GDSL-hydrolase-family-protein
MKRFPSVVLLALSIACSSAFAAKPKANDAVATDSTLPNVLILGDSISIGYTPVVRDALKSKANVIRPSANCGETRMGLAGIDDWLGDGKWDVIHFNWGLWDLCYRNPDSKTQGNRDKVNGKQAIPLAEYEANLERLVERLKQTGAVLVWASTTVVPEGEAGRVVGDELKYNAAAERVMKKHGVRIDDLHSLTKRFEPELFTKPGDVHYTPAGYGKIGSQAAAAIEAALKK
>NZ_CP036274.1|WP_145083076.1|19143_20196_+|sialate-O-acetylesterase
MMRCAMVLLIAATMAAEPLTAADKPVKVFILAGQSNMEGKAPNTLLDYQATDPKTKDQFAHLRKNDQWIVRDDVFIKFLDRKGPLTVGYGSPGRTGAELEFGTAMGNHFEEPVLLIKTAWGGHSLYKLFRSPSAGYPAEEVLQKELDQAQAKIRKNNEKNKKNDPLPTMEEMKKEYGSSYRNMLAEVKDVGDSYATMFPELQGKPLELAGFVWFQGWNDQYGAENEYASNMKHFIQDVRMDLNAPKLPFVIAAMGQNGSKPAAGAMLTIRDAQLSMNDVPEFRGNVKAFRTDLLVDKAAEELYPTWQKNFEQWKLVGGDRAYHYLGSAIWFNRIGKAMGEAMLELVPPRQ
>NZ_CP036274.1|WP_145083073.1|17902_18709_-|hypothetical-protein
MISRPRLSMPGASTTSPVSARSSWSGQIVVGSVTVPVKAYAAIASPSNSTLHLIHRDCGQPIAQPRTCPTHGPVTTDDIAKVFRFAPGDDVVLSPADLDSLKPQDDDQLRIEHLLTSPGFDLSLTSGRTLFLIPAHAAAAPEYGVVCSLLAKHNLWGVGRAVLHDRSQLIGLHVVQDVLTAFVLQWPQARRACPAFDRTPVDPQRLRQLEKETLLLRKSFAWDEYQDDYEPRLTELVRAKIAARAVSTATTTAKSRKKPNPTLTARAA
>NZ_CP036274.1|WP_145083070.1|17061_17919_-|hypothetical-protein
MHGPLNPGETHITNPRSGDGLSTFRFRKRTPGTFVLVPFAKQGRSIRCQGQLEAAAAQILVASPVVRSLEEQPLTIWYAWDDVGGIELLAGPPLRKPPLPRRASYIVPDFLVQFHSGAQHLIEVKPSAKLARPDVQRKLSVARQFAERQGWTFHVVTERELRVGPLLNNVRLLNRFRCVSVSVEMARHIQELVAGQPRRWLDMAQKLSAHAPIAIAKTWLLHLAATGQLDIDPRGAPITDATLLYPGGTIAWDPFDSVWVPSGSSTVGPSGSSANSAPTNSLPKT
>NZ_CP036274.1|WP_145083067.1|15157_17167_-|DDE-type-integrase/transposase/recombinase
MGSIRLGVGTEWLLDGRSFRIVRQLGPHEFIAEDLKYRLERSFSEQELLDQYARGRLRFVPNTPESETAASTDRPATMVVIAHAEFKKVADRWLAIEPLTKLDRPPTESDFLARQAELTTAGKCCSARTLRRWFTRWKRAGYDRLNLSARFRNCGGRGKSRSQGWLRRFPLLRELVDRAIREVYLTTARRPMSAVVRRVLEDLQRHNSRTSAAQALPVPKQGSLARTIARRVNQLDPYEIDRARWGHRIADQRHQATTRQQLATRVLERVEIDHSPLKVVVGTQAGPIGQPWLTVLIDYYSRLIVGFCIGFEPPSYAVIMEALRQAILPKTYLRTKYPQIVHDWPCYGVPEKLICDRGSDFTSNDLEQAAFQLGLELDFMPPRTPHLKGTVESFFDTLNDQLLSALPGRTFRSWEKRADYQPDDGPLLPYEALVEIIHRHLIDVYAQEKHPTAAKTRLEMWQESVAEFPPALPSSPDDLVVLLSKTVERTLSVRGIELNGMFYAGDELFALRAELAANNLPADKLTVRYNPWDLGAIWVLNPVNRHYLPAVAVDAAMQGLTEYQWRVLRRVVRERFDDPDRLLSLAAARNAIRDVVDAAVTKPSRRRRTRAARFAGAYQNGPEQPADNPPESAADHTVSSIPEEPQVTAEETIEINLAELNVDDWDVAG
>NZ_CP036274.1|WP_145083064.1|14067_15126_-|AAA-family-ATPase
MTSSTGPPSDEDRARWRSVPIAERITLAQKLIVLHPRFRDAVGLLERCHRSFGQPNEPACGALLGTSGVGKTSVVDHYSKLHPGGETETGLRRPVLKVTLQPEARPKGIAADLLLALGDPAWSSGTVQTLTNRAVKLLHRCGVELIVFDEFHHLFDIDRAKVMTKAAQWLKVLIVNTRIPVVVCGMPEAEHVLRAEHTERRFKERLTLRCFNWRTPAGRQEFCGMLKRLDGVLPLAESSGLAEPDMAGRLFLACRGVSDYLMTLMRSGVAETLGRGQERIEVADLARVFAQKLALQRVLAEQANPFIGPLDAGALDRVQPADIARGPGIGLTPRATRAKQRSLTANQLLGGS
>NZ_CP036274.1|WP_145083061.1|12147_14067_-|helix-turn-helix-domain-containing-protein
MHLRSLPVRESPLPGESLTSFVRRHVVGMGYESMVRLLSLVDEVELPSHLDHLGRGPPLGALSGLLGRPSSLLADLTVHRFAESLVLQPQGAPPATLCDSKTLLRFFDPAHPRVCPECLREGTTYERLLWSFRPLPICLEHGVTLLDRCPACGRHARPARLDLEICRCGFRLTETAAIMIGSGAFSSAALIQTCLRGEPFAALDLSPAAALAWLDRLRSAVARTPSWIERTRETFQLPGSLSAESVAWLGAAEFLEVGPARLAEFLDVYQGIAKHRSTSTGVNRAFGHLLRDAERLESLGYSGPADALRQYLLGRYTHGHLSGKTTLFREASRRRQLRAREWIPQTAAARQLGICVPTLARLVRQQVLAGRVHPAGKQGRTVGLVSRAAVVDLQRRLSTGFTVTQAAQRLGVDRHRVLELIQEEVLAGVVRIARRWRIPAAAVEHLSATVAQLPPLLDRTSEWLSLREATRRFGAGHLNLARIVRLLCAGRLSARREPNETSLRGVYLQLSDLRSCTEEATAQHSVTAGWTLNRLAKLLFPEQPLKDVVLRKWMGAGLLRGKRQAKQWCIVDEEVARFRTTYCLAQEACRILGISRSTLARWERDGRIAPVYGKRTHRAAGASLFRRADLSRLLDRTAA
>NZ_CP036274.1|WP_145083091.1|26308_27634_-|DUF2130-domain-containing-protein
MFFSDRVMQRPLSTDMNTNPRQNGTQRLNNTLSCPNCNHEIELTELMRTQVASQIRGELDAHAATRQRELDKQREEVARQKLQLDKDREAVAEQIRTQVEQQRTVLLTEAKKRAEDAVAVEIADRDERLKELSTSLDSARMQELDLRKMQRQLQSEKDSLKLEVQRQLDAQRSQLITEAKAQFDVEHAFKQAEKDKTIADMTVKLREMQRKIEQGSQQLQGEVQELALERMLADTFPTDEIAPVSKGVLGGDCMQVAINGSGTACGRILWESKRTKRWGGDWLAKARDDARASRADVVVIVSETLPDGIQGFAPVEGVWVCGWAAAKSLATALRHGLIEVGKARVALVGQHAKQELVYNYLASSEFAHRVGGIAEAFATMQTDLESEKRAFKKQWSKREKQLERAIMNTTSLYGDLQGIIGASLPKIAGLETMLIEDQREV
>NZ_CP036274.1|WP_145083094.1|27749_28634_-|hypothetical-protein
MSLVAEYYQTLGGLFREVYGSVFPEAVRSKVCGEALGTQVQSEIFLLLAGDRAADEVRETSEKAIEQFSDERDRQRQYQFRSEIEAIDGNWDLAREFLAKGIGCDSTDHQSIGRFIASVPESARPFPLLHWTRIGGMAAVASDQVEFESFADAWRTTGLDAFVKKLALTYPAHGILRRMACVYSALGDDAKLIETLRSLRSVVKANPTTLFGLIEVAAVLQSSGLAGRRNRDQMMRILGGSKNDPAATELLKKIARDSGASQPKIAAVASKWEQLLACTPTPQQLVDAAKIVAY
>NZ_CP036274.1|WP_145083097.1|29152_29416_-|hypothetical-protein
MKAPKTAGQPVNTLTSTYNSRYHFLTDKYHALSITFSSGRRDAAMFIFGGTLGRALDDVSRRRGDQQHYALLRVTTFSTFVREFSPF
>NZ_CP036274.1|WP_145083100.1|29412_30765_-|hypothetical-protein
MKTFVVSLIAILILAGETNASRGATPPAGRLMAGTAKVEITPEPHTAVNIAGIPLEPRDSLYARVLVLRNGDTSVAIVSLDLIVFASRKVVDEAKAKFGVDQVILSATHTHAGMNPRGLLIKPPAQPDWTRLPRAPADVIDWPALSADPWYAATEAKVVEAIGRATKSMFLARIVSGKGTFESAYMAHNRRLVKNGLASPFWENPDRRPTSPIDPTIGVVRIEDLSGKPRALAVQYACHPVATMGAGSVSRDFPGGMVDYVEEQLGPDCLALYLQGAQGDLDPYDLHNLRGENRFNIPKQAGISLGKRALNISADLKTKPESARATIDVAESLLTIPNRNGSGTTDVGLLTVVVDKNLALTAIPGEPFIQHQLDLTQLSPLPNTFILGVAYSGRGSPFVVYIPTEQAVREGGYGATECSFLAADAGAKIVVESAKKIQELTKAESPEKKP
>NZ_CP036274.1|WP_145083103.1|30997_32749_-|hypothetical-protein
MLEQGKVAEAQAEIQRIDEAKMTIPVYRVALTKAVVATQEKQQVETFNGHVMPLQRSLRRILLTAACCSLVLSSNFARAEVKVTESAEAIRFEVDGKLFTEWRTKDWVAPFLYPIVGPNGESVTRHYPMKAGMPGEEQDHPWHRSIRFSHSDVNGFNFWWAPGKKLAGHTAEIKLEKIERLTSGATGEAIFWNEWLGDGKRLLRERVRLAVTPLPRGETLLDYDTELHASDSPLKFGDKRDGGLLVRVAGTMKAEDEKGNKFAGSIVNSQGDKNADAWGKRAEWTDYFGPDASGKTVGIAMFDHPTNLRFPTHWHARTYGLMTANRFGTDHFKGNYGDHRTLICAPSKGANCPACASHSGDYEISAGGSLTLRHRFFFHHGDPNSGGVAEQYLAYTADPKAAVLVMKSLLQSYKSGSLVDRYAGVDFRAWPAEFAAEKSEALRLRAAAYSVVKKGTHAEADYKAALTLDPKDLSAWIGLADNYLNVVGDGAQAVATYRKVIELSGKNAGWMPLHATLAIAREAIDRAKPEQALETLKQFDGVTVAPVWRVKILRMFGHAYAAQGNEAESLAKFREALELENAK
>NZ_CP036274.1|WP_145083106.1|32901_33783_-|M15-family-metallopeptidase
MQANNTMTTCTDEVARRAYWAEQMQLGYELVQQILPFEVAECGEGFASLRDAAETAGIEMLFSDTKIAGELDRVFFMRESLVQAVMDVGRDMNQRGWILKIEDGYRSLEMQGSLVRKPELFDSILKKCIWEIGGEIPSAEFVFRRAIVLIANIPKIGTHMSGSAIDVSVFRRDEGSEVWRGRPYLEMSEQTPMRSPFVDEDSLRNRLEITAMLEARGFVHFPFEFWHFNQGDALGNILSGRAAPARFGPVHWDPRTNRVTPVDDPLSPLNPLPVIEREIASALQRATDRVVVV
>NZ_CP036274.1|WP_145083109.1|33814_35128_-|hypothetical-protein
MKPAWHWTFLWTCSVLIVFASYSLAEDSSHFRVESNLRASVVKIDITPPADTPVVGHVRPTNGVRDPIRAGVLLLANEQTRAAIVTLDLISASGEMVAALRDVIALKTEIPRENIMVATSHNHSGPGWSRESAWSREMVAKLGAAAGEAAKTMRPVTIGYGEDRIDFNINRRKVIDGRALFRLNPDGPCDHRVKVLRFDDGRTLEPMSILMHAVCHPCVFTWGDKLTPPFPQGFPKISADFPGEAQTFVETVYGPKTQTLFLQGCAGDIRPNLPGVPYRCGDEADIKWTGRSLGCAVVRAADRSVVREELAKRKTIYPLKCASSVIELPGKKEPLACEMQAMRIGDYLLLTIPGEPMVEYGFQIEKAIADRAIPIVIGYANGNLGYICTAKSHEYGGYEPESSKLLPEAEPLILKELGRLADKALADIFESIKPTSK
>NZ_CP036274.1|WP_145083113.1|35236_37039_-|CocE/NonD-family-hydrolase
MKYFLFVLTLITFSPASLLAQAPNPGRISAADHKVVELHNQKVSMRDGMSIALDIYRPAGDGRFPAILCQTPYGKGTMAVRARWFAQRGYVVINSDVRGRFGSEGEWDPFSPLHKSDGYDLVEWVAKQPWCNGRVGTYGQSYLGWTQWWTATQAPPSLKCIVPEVAPPDQFFNGPYQNGVLVGWAMDWAALMANRTMNVVGKGAYGGFAETRDVDYRRLPYIDLAKHRGVGHAKWFETWIRQNTADGDYWRAIAYQTPEQSARVQVPSLGISGWFDANFSGTPSNYLAMKQHGGTPEARQARMVIGPWNHQINLSPKVDYADFGASSVIDWDGYVCRWFDYHLKQIDNGVLKDPPVHVFIMGRNEWRTASDWPLPETQWTKYFLHSAGKANGSGGDGTLSINAPADEPPDGYTYDPTDPMPSPHFVNGHIAGPRDVRRAETRSDVLIYTTPVLEEEVELVGPITAKLFAATSARDTDWMIRLIDVHPDGTAAFLCEGVMRARHRDPENEGAYNPSRLSTIEPNTIYPYTIEFWRATGNAFAKGHRLRIEISSSFFPYYLRNLNTGADNVGLETDSVVAKQTVYHDRDHASHIVLPVIPRR
>NZ_CP036274.1|WP_145083116.1|37219_38527_-|hypothetical-protein
MDITPDEAFISAKGESWRLPDPPAVAGGKKTPPANIHDPIFARVLVLKNAETSLAIVSLDLILFSSKKVITEAKAKWKVDHVILSSSHTHTSMIPRGLCPTGAVRSWGWDYVQDDPGVTVDWPGLSEDPWYAATEAKIVAAIGEASTNLFPAQVVAGRGPFESAYMAHNRRLVGADGKVTDMWDNPKRLPTKPIDPTVGVMQVNDRSGNPRAFLVHYACHPVGLMGSGVLSRDFPGAMVDYVEQKLGSDCMAMFLQGAAGDLDPYDMRLHGEHGFNLMRQAGISLGKGALRVARTMKSRQDARSSSIKVKENLVKLPHRNGDKVTEACVMTAVINDDLALVTIPGEPFIQHQLDLTAKSPLASTFLLGYAYCGAGSPFLIYVPTVQAVKEGGYGADVNRCSFVSGDAGERMVNTGVTAIKQLLALDGTPTGTEKP
>NZ_CP036274.1|WP_145083119.1|38747_39443_-|SGNH/GDSL-hydrolase-family-protein
MNHKSLNITATLLFTATAMTHAWAEDPYNYKKPRESQNWTTISLKTKTANGPDLPLVLLIGDSITVRYAAEVGTALKDKAYVSVLGSSKAADDPALLDEIKLVLRQNAYSVIHFNFGLHGSAGDLRTGLPVVIATLKRHAPNAKLIWATTTPCQKKDDAPDTDVIEKNRVAAEPIAEAGIVVDDLYTLVAKHPTKLWDGGGVHYTAEGTAIQSKQVAQAITPLLPVAPAAK

Crispr_ID: NZ_CP036274_2

• CRISPR_ID: NZ_CP036274_2
• CRISPR_location: 556580-556681
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP036274_2

Consensus_repeat	Method
GGTTAACCGGGCCGCTTGCGGCCGTTGAAC	CRISPRCasFinder

spacers of NZ_CP036274_2

>2.1|556610|42|NZ_CP036274|CRISPRCasFinder
CTTTAGGCCGGCGATTTTGCAGTTCACCCGCGCAAGCGCGAG

CRISPR arrays and Neighbor proteins around NZ_CP036274_2

CRISPR arrays

The CRISPR arrays of NZ_CP036274_2

>merge|NZ_CP036274|2|556580-556681|CRISPRCasFinder
GGTTAACCGGGCCGCTTGCGGCCGTTGAACCTTTAGGCCGGCGATTTTGCAGTTCACCCGCGCAAGCGCGAGGGTTAACCGGACCGCTTGCGGCCGTTGAAC

>NZ_CP036274|2|2|556580-556681|CRISPRCasFinder
GGTTAACCGGGCCGCTTGCGGCCGTTGAAC	CTTTAGGCCGGCGATTTTGCAGTTCACCCGCGCAAGCGCGAG
GGTTAACCGGACCGCTTGCGGCCGTTGAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036274.1|WP_145084168.1|565487_566252_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|379312
NZ_CP036274.1|WP_145084153.1|559528_560542_+|porphobilinogen-synthase	unknown	unknown	gnl|CDD|236450
NZ_CP036274.1|WP_145084134.1|553005_553380_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145084119.1|545408_546464_-|DUF1611-domain-containing-protein	unknown	unknown	gnl|CDD|225902
NZ_CP036274.1|WP_145084125.1|547694_549893_-|ferrichrome-ABC-transporter-permease	unknown	unknown	gnl|CDD|223498
NZ_CP036274.1|WP_145084128.1|550170_551292_+|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|239310
NZ_CP036274.1|WP_145084139.1|555164_555503_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145084165.1|564865_565324_-|DUF1768-domain-containing-protein	unknown	unknown	gnl|CDD|271319
NZ_CP036274.1|WP_145084131.1|551310_552903_-|CRTAC1-family-protein	unknown	unknown	gnl|CDD|369440
NZ_CP036274.1|WP_145084137.1|553917_554115_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145084122.1|546916_547672_+|LmbE-family-protein	unknown	unknown	gnl|CDD|274915
NZ_CP036274.1|WP_145084148.1|557364_558693_+|MFS-transporter	unknown	unknown	gnl|CDD|340866
NZ_CP036274.1|WP_145084162.1|563053_564850_+|hypothetical-protein	unknown	unknown	gnl|CDD|224771
NZ_CP036274.1|WP_145084156.1|560568_561501_+|carboxylating-nicotinate-nucleotide-diphosphorylase	unknown	unknown	gnl|CDD|238806
NZ_CP036274.1|WP_145084159.1|562641_562902_-|zinc-ribbon-domain-containing-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145100076.1|561528_562497_-|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|226145
NZ_CP036274.1|WP_145084145.1|556050_556542_+|acetolactate-synthase	unknown	unknown	gnl|CDD|153180
NZ_CP036274.1|WP_145084171.1|566532_567231_+|pirin-family-protein	unknown	unknown	gnl|CDD|380375
NZ_CP036274.1|WP_145084142.1|555609_555945_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145084151.1|558790_559342_+|transposase	unknown	unknown	gnl|CDD|224854

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP036274.1|WP_145084119.1|545408_546464_-|DUF1611-domain-containing-protein	gnl|CDD|225902	COG3367, COG3367, Uncharacterized conserved protein [Function unknown].	4.8624e-84
NZ_CP036274.1|WP_145084125.1|547694_549893_-|ferrichrome-ABC-transporter-permease	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	1.15852e-08
NZ_CP036274.1|WP_145084128.1|550170_551292_+|redoxin-domain-containing-protein	gnl|CDD|239310	cd03012, TlpA_like_DipZ_like, TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.	1.86679e-38
NZ_CP036274.1|WP_145084156.1|560568_561501_+|carboxylating-nicotinate-nucleotide-diphosphorylase	gnl|CDD|238806	cd01572, QPRTase, Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide. QPRTase functions as a homodimer with two active sites, each formed by the C-terminal region of one subunit and the N-terminal region of the other.	1.06061e-127
NZ_CP036274.1|WP_145084165.1|564865_565324_-|DUF1768-domain-containing-protein	gnl|CDD|271319	cd15457, NADAR, Escherichia coli swarming motility protein YbiA and related proteins. This family of uncharacterized domains was initially classified as Domain of Unknown Function (DUF1768). It contains members such as the E. coli swarming motility protein YbiA. Mutations in YbiA cause defects in Escherichia coli swarming, but not necessarily in motility. More recently, this family has been predicted to be involved in NAD-utilizing pathways, likely to act on ADP-ribose derivatives, and has been named the NADAR (NAD and ADP-ribose) superfamily.	1.7925e-66
NZ_CP036274.1|WP_145084131.1|551310_552903_-|CRTAC1-family-protein	gnl|CDD|369440	pfam07593, UnbV_ASPIC, ASPIC and UnbV. This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.	0.000251066
NZ_CP036274.1|WP_145084168.1|565487_566252_+|methyltransferase-domain-containing-protein	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.31301e-16
NZ_CP036274.1|WP_145084122.1|546916_547672_+|LmbE-family-protein	gnl|CDD|274915	TIGR04001, thiol_BshB1, bacillithiol biosynthesis deacetylase BshB1. Members of this protein family are BshB1 (YpjG), an enzyme of bacillithiol biosynthesis; either BshB1 or BshB2 (YojG) must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	2.48143e-50
NZ_CP036274.1|WP_145084148.1|557364_558693_+|MFS-transporter	gnl|CDD|340866	cd06177, MFS_NHS, Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters. The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.73052e-140
NZ_CP036274.1|WP_145084162.1|563053_564850_+|hypothetical-protein	gnl|CDD|224771	COG1858, MauG, Cytochrome c peroxidase [Inorganic ion transport and metabolism].	3.1288e-13
NZ_CP036274.1|WP_145084171.1|566532_567231_+|pirin-family-protein	gnl|CDD|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	4.61814e-79
NZ_CP036274.1|WP_145100076.1|561528_562497_-|amidohydrolase-family-protein	gnl|CDD|226145	COG3618, COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	5.06504e-65
NZ_CP036274.1|WP_145084145.1|556050_556542_+|acetolactate-synthase	gnl|CDD|153180	cd04908, ACT_Bt0572_1, N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains. Included in this CD is the N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains as seen in the uncharacterized structure (pdb 2F06) of the Bt0572 protein from Bacteroides thetaiotaomicron and related ACT domains. These tandem ACT domain proteins belong to the superfamily of ACT regulatory domains.	8.70703e-23
NZ_CP036274.1|WP_145084153.1|559528_560542_+|porphobilinogen-synthase	gnl|CDD|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NZ_CP036274.1|WP_145084151.1|558790_559342_+|transposase	gnl|CDD|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	3.50226e-31

Protein sequences

>NZ_CP036274.1|WP_145084145.1|556050_556542_+|acetolactate-synthase
MSIGEGMDTGYVTARGKGFPTIRQFTVFLENRVGQLMEVIRRFEGSKVRIVALSINDATECAFVRFLLSHPEQGREILERAGLAIIESELIGVELPQTNQPLLEVCTALLQAEVNIVQAYPLLIRPHGQPAVALMVDNLDMAMSTLNAKGFSMIHEADLADED
>NZ_CP036274.1|WP_145084142.1|555609_555945_+|hypothetical-protein
MNLPSPGDLAKTNQRLASNNARVTALLNSLPLLLDHLIAAADRRDWLEVVRQSESLAEMGRAMKCDTLAIPAGELAAVTEARSSELEIKRHLLRVIGAAGRARKTSFLAGR
>NZ_CP036274.1|WP_145084139.1|555164_555503_+|hypothetical-protein
MGLAQWMADWLVTDKVAQLAERIAGRSRLATYQRVCERLYSLEAHEARGYVRTRAATIVTAEADKLIAQEGVSAGKLRDKLIASAMDSLVSAILLQAEQARRAKPTTRRLAA
>NZ_CP036274.1|WP_145084137.1|553917_554115_-|hypothetical-protein
MDKPHTSVAPIFVAIVLLLLQVLYVGSYLALVQPEGDFVDLPTGGYYVSHYRIPGTLPSKFFRPL
>NZ_CP036274.1|WP_145084134.1|553005_553380_-|hypothetical-protein
MDAPEGFSIERNRGIYCPVGTVSFDEVVALVSAAITAACAQQVEELLVDTTGLTGFHSPSTIQRYAAVVKWAESANRRLRLAMVAQQEMIDPQKFGVLVAGNRGLDSNIFATQTEARAWLDASA
>NZ_CP036274.1|WP_145084131.1|551310_552903_-|CRTAC1-family-protein
MNNYIVQSFVALLFGSLSACAVVAAEPTAEPVRLPLVKVAPEESGLTHVINSEPERGKLDYPWMSPPIDFDGDGQLDLIVYGHHGGGAAIWLGRGNAKFVLDEGPYARRWLFGARDPVWWAGGNAPHAIGTEGSNISGYFFLNDGAGNYRKSAQQLPQAGYGDFQLADLDGDGLHREAYMSGAGAALRLTPSPDQWPTAADAKLKSETLWESESLVGWPAGIEHGRGPGRPGYRDAYAVDLDGDERNELIVHFRGEGFYSSQLFTWILVRKESKDGSSWQDATAAFGLPASATAWLFPEDLDVDGDLDLVDLHSGRWHANDGRGKFAQQEQLVFDPEKRGLPNRRGHPWTTDNELQWLDLDNNGYRDLVTASDHGTQHGAFLNLGGGRFVEVDGILGGRRNRKFGDVDNYGRLDMATFDGKQLTLHRNQTAASGLHVKLVPKAAGDVHLGAKLWVYQPGKLGDAKSLVHYRQGFMERSAGRSTVLVPRLHIGLGEFKTVDVRVRFPSGVVREISGASAGSEVVLYETKKL
>NZ_CP036274.1|WP_145084128.1|550170_551292_+|redoxin-domain-containing-protein
MMCHRSRALPMRTVFTTFVVVAFASLLSGLTARGADPFAGADPSWALLHEPAVVAELKLSSTQRVAYQELMDSVDLRFFPLRNKSREVVVAVVDEIMGECQQKLNTLLLPAQSKRFREILMRKLGTAALVRDDLDLQMDYTDEQLKQLKTIVDKAAAAVTALEKEASEGKPRQPLEEKFKDVKLKEQQEILALLKPAQRTKWQQAVGAPFDLSRLGQTAYRAPEIVDTKDWINSPAMKLADQRGKVVVLHFYAFGCSNCIHNYPWYREWHDKFQGKDVVLIGVHTPETAGEREAANVRSSATKEKFAFPVVIDGKSENWNAWGNSMWPSVYLIDKRGYLRHFWPGELKWQGLDGEKYMRERIEQLLTETDAKS
>NZ_CP036274.1|WP_145084125.1|547694_549893_-|ferrichrome-ABC-transporter-permease
MRSATATFVVFAGTIFLSAFLLFQIQPLVSKFILPWFGGTPAVWTGAMLFFQLVLFGGYFYAHLLSKWCTIHQRLTVHLSVLALAAANVAWGRLIPPESLRPQGEAGEIPLIQLLLLLTVTVGIPYFSLSATGPLLQRWLHDSLPGVSPYRLFALSNLGSLLALLSYPFFFEVQWGVVAQASIWSVGYVLFVVICACCAIRTWQLSKPATRVANEQAASVDKSIPIPEKITPAVASLRDKAIWLGLPTLASVMFLATTNEVCQNVASVPLMWVIPLSLYLVTFIIAFDHPRWYPRQIVAWSTLVLLAFVIYYDTTLETVDQVANSLLGSTADDSIELGGLWWLQASIYFLTMFAIALMCHGELARARPAPQYLTSYYLMMSFGGALGGLLVNLAAPFLFNTFFEFPLALMTAALVAIVLIWAGSSTSKLRWPAVGGAVALGATSIVGLLLDSAPSTSTHNKTVHVSRSFYGIVEVMHRAIGDVDENYTFYSGTIQHGKQLAEPTRRAIPLTYYGAGSGCEVAIKFAQARSEQCRIGVIGLGVGTIATYARSTDSIRLYEINPKVIDIAQDQRWFHFLSDCRCKPELVLGDARLQLERELKAGGSQKFDLLVVDAFSGDSIPTHLLTREAFDVYQQHLAPGGLLVVHITNTHLDLFPVVSKLADQAGFGYRRIYQQGDLDRLLYRNYYMLLSKDETFLAQTRDQIDDLPDYLRHPRNIPLWTDDYTNLTALLR
>NZ_CP036274.1|WP_145084122.1|546916_547672_+|LmbE-family-protein
MNPELSTALNRWPELDVIAVGAHPDDVEIACGGTLAKLVKQGYRVGIIDLTDGEPTPRSPGPEVRLAEARKAAEKLGVQVRVTLDLPNRRLFDSFEARVALAKEFRKYRPRVVIGFGDKTPLASPDHWQAMQITDAAVFYARLTKWDHHFEDLPVHVIASQLYFRLAFEPANLQGFPSHFTVDITETLEAKLASVACYETQFPKEKAYVFDRVKGAALIAGAASGFHAGETFVSVRPLGAIDLVKTALGQV
>NZ_CP036274.1|WP_145084119.1|545408_546464_-|DUF1611-domain-containing-protein
MTSRKIVCLTEGHSEPHAGKTAANVIRYRREEVVAMLDSTQVGKNSRDLFAVTTGEPVPVIANLDEAPSANTLLLGIAPPGGKIPASWRKIILQAIGRKMDVVSGLHDFLNNDAEFKQAATAAGVKLVDVRSNSEKSIARRKGLRPDCLRVHTVGHDCSIGKMVVSVEVTNGLKKKGWDAKFIATGQTGIMIEGDGLPIDCIVADFVSGAAEKMVLEHQHHQILLVEGQGSLVHPSYSGVTLSLLHGCAPQALILCYEIGRDTVTGVESVKIPPLAEIKKMFELMANIHQSCQVIGIAINSRRVDAAAAAAERARVKAEFGLPACDVLRDGPDELVDAVIAFHEQGGWHSP
>NZ_CP036274.1|WP_145084148.1|557364_558693_+|MFS-transporter
MSRASDPLKSPAHAGPSGTGIKLFFMMVLEFFIWGAWLPLIFGYLPAMGLTENEQKLILSAFPVAAIIGMFFSNQFADRNFSAERFMAFSHLVGGLAMAGLAWVRFDRLPLEAGEVIKPYDTPFWIFFGLMSVHCLLYVPTISIANSIAFSHMKNSEKEFGIVRMGGTIGWILAAWPIAFILYGKPEAEVLKATSAIFIVSGGASLLLAAFSLILPHTPPNKATGAESFALLRALKLLATPAILVLFIATFIDSTIHNGYFVMTGNFLARAGIEPAWIMVVMSLGQVAEILTMMFLGLVLSKLGWRWTMIIGILGHAARFSVFALFPESTTLLVAVQFLHGICYAFFFATVYIYIDKVFPKDIRTSAQGLFNFLILGVGDLAAKWLFIPLQTHFVGPTGLTGYRELFMIPTAMAIGAALLLLFFFHPPRDAEEPVAIKAPSH
>NZ_CP036274.1|WP_145084151.1|558790_559342_+|transposase
MPNYRRNYVPGGTYFFTVVTYKRRPLFHDEVIRGLFREAIQHVQAKLPFEMFASVLLPEHFHCIWTLPHEDANYSRRWRQIKEKFTYLFLRSGHRGLERSASQKRHREQAIWQRRFWEHTVRDVDDLERCTNYIHWNPVKHNLAQRVKDWQWSSFHRFVQAGDYPLDWGSADPCPGYHSPEWE
>NZ_CP036274.1|WP_145084153.1|559528_560542_+|porphobilinogen-synthase
MNQRSAADSGFPTTRMRRLRYNAGVRALIRETTLAPANLILPLFVRPGKNIKQPIGSMPGQFQLSLDQLAKEAKEAEQLGIAGVILFGIPAEKDLQGSDSYCDQGIVQQAVRTVKEAAPKLLVLTDVCFCEYTSHGHCGLLEERNGQQDVANDPTLALLGKQAVSHAQAGADMVAPSGMMDGMVGAIRYALDHAGFSHLPLMSYAAKYSSAFYGPFRDAAESAPQFGDRRTYQMDPAAAAGQALREVELDLREGADMIMVKPALAYLDIIRDVRENFPGVPLAAYNVSGEYSLVKAAAANGWVDERTLALEMLTAIKRAGASIILTYWAKDVARWLS
>NZ_CP036274.1|WP_145084156.1|560568_561501_+|carboxylating-nicotinate-nucleotide-diphosphorylase
MAKEYRQLTWDADVEHDCRQLVRLAILEDLERGHDWTTVALASEEARSVANLVARQSGVIAGIEAARITLEEMEIAASWEPQVADGAKVERGALVARLRGPARGLLTAERTLLNLMGRMSGIATLTSEYVAAVAGTGARVYDTRKTTPGWRRLEKYSVRCGGGHNHRLGLFDGVLIKDNHLALGREGSAATRYTPAQAVQRAKAFLYEHGAGQERFAEMMVEVEVDSLAQLREVLPAGPDIVLLDNMPPDVLRQAVAIRNELAPHIELEASGGITLKTIRSVAETGVERISSGALTHSAIVLDVALDWQE
>NZ_CP036274.1|WP_145100076.1|561528_562497_-|amidohydrolase-family-protein
MSRRDWVIGSAAAGLLATTATAREEKPMLPLIDCHQHLWDVTKFKLPWLPASGVLARSYVLDDYRQAIVGTGIDRSVYMEVDVAPEQQTAEAEHLIAICKSGTAPTVGAVISGRPGDEAAFKKYIAQFKDSPQIKGVRQVLHGDSTPAGFCLSPAYVKSVQLLGEMGLSFDLCLRPGDLADASQLADKCPDTRLILDHCGNADPKAWLSATRRGDQKPDHTVEPWKKEIAEIAKRKNTLCKISGIIARVTKEWSADDLAPIVNHCLDSFGPDRVIFGSDWPVCLLGAPLKAWTEALRQIVAARSEAEQKKLFSENAVKYYRL
>NZ_CP036274.1|WP_145084159.1|562641_562902_-|zinc-ribbon-domain-containing-protein
MKRHNQNDDDWDDEEFDNSDDEPTIDCPYCRREIHEDSQRCPYCERYISDEDSPPTRKPWWIYVTVGLLLFVMLDWLLWALYGLLF
>NZ_CP036274.1|WP_145084162.1|563053_564850_+|hypothetical-protein
MSLVSSTVLHRSGAQVSGLLVGLILLATCPAAEPAAPKLATQLRRPIALANDAQGEWLYVANRESGSITSLTAAGKVTSETAVGKQLSDFIPVPGSDLFLATDEQAHQLLVLRMKGDQITVLQRLAVSPYPVGVTVWDDGKQAAVTSLWSRRVSFLALNRNGDKKQEIARITKVLDLPFAPRKLIMLPQQQKLIVADSFSGKLAVIDPKKQTLEAVRQFPGHNIRGLGISPNGEMLLVSHQMLNELAHTIRNDVHWGLLMSNDLRWLKIESVLAGGKETYFGSHMHPLGEAGQGGGDPAGFDIATDGTVAVTMSGAGQIAVGKEEDFSLQRIEVGQRPVAVKIAADGKTALVVDQYADCLVRVDLALQEVTERISLGPTPELTEAQKGEVLFHDSRLAHDRWMSCHSCHADGHANGQMNDNFSDKSFGAPKRVLSLLSQKDTAPYGWNAKAEDLLVQIRNSLENTMQREDEIPADDVKAIAAYVSTLELPPPLDVLRGTTDSAAIARGKLVFENHDCARCHAGPNFTTPKAYDVGLTDKQGNKEFNPPSLRGLSHRGPFFHDNTAATLEDVFLKHQHPAKAVYSAEEIKDLVHYLRSL
>NZ_CP036274.1|WP_145084165.1|564865_565324_-|DUF1768-domain-containing-protein
MTEPIQFYSTADAYGEFSNFAAYPIELKGKTWPTSEHYFQAQKFAGQPDKEEIRRASSPLLAARMGRDRQRPFRTDWEAVKDSIMREAVLAKFTQHANLREILLSTGDAPIVEHTTNDNYWGDGGGSGKNMLGLILMEVRTKLREEATASQP
>NZ_CP036274.1|WP_145084168.1|565487_566252_+|methyltransferase-domain-containing-protein
MVRDKQRFTRPARDEDFVDPLKTVDALGWLGGDIRGQRVLCLGAGGGKHGPLYAAAGARVTVVDISAAQLELDREVAAERRLEVHTVEASMDNLQCFQASEFDLVVQPVSTCYVPQIGPVYAEVARITRPGGLYVSQHKTPQSLQADVQASAKGYELTEPYYRTGPLPPVVGSRHREEGTHEYLHRWDEILGLMCRSGFVIEDLVEPLHTKPDAIPGSWEHRSKFVAPYVRIKARRTGEKAAASTATSRLWLPS
>NZ_CP036274.1|WP_145084171.1|566532_567231_+|pirin-family-protein
MFAVRKAADRGHADHGWLNTYHTFSFSSYRDPRHMNFRALRVMNEDWVAAGQGFGTHPHRDMEIVTYVLEGALEHKDSMGNGEVLRPGEFQRMTAGTGITHSEFNPSTSEPVHLYQIWLFPEANGLTPSYEQKRFADEERHNRLRLVASRDAAEGSLLIHQDAKIYLASLDQGQSVTHSLASGRHAWLQVLRGSVTLNGQALATSDGAAISDETSLTIEATNNAEVMLFDLA

Crispr_ID: NZ_CP036274_3

• CRISPR_ID: NZ_CP036274_3
• CRISPR_location: 3532570-3532649
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP036274_3

Consensus_repeat	Method
GCGAGTCATGTAATGACTCGCCTACG	CRISPRCasFinder

spacers of NZ_CP036274_3

>3.1|3532596|28|NZ_CP036274|CRISPRCasFinder
TAGTTCGGTCACTCCGTGACCGAGAAGC

CRISPR arrays and Neighbor proteins around NZ_CP036274_3

CRISPR arrays

The CRISPR arrays of NZ_CP036274_3

>merge|NZ_CP036274|3|3532570-3532649|CRISPRCasFinder
GCGAGTCATGTAATGACTCGCCTACGTAGTTCGGTCACTCCGTGACCGAGAAGCGCGAGTCATGGAATGACTCGCCTACG

>NZ_CP036274|3|3|3532570-3532649|CRISPRCasFinder
GCGAGTCATGTAATGACTCGCCTACG	TAGTTCGGTCACTCCGTGACCGAGAAGC
GCGAGTCATGGAATGACTCGCCTACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036274.1|WP_145088838.1|3545138_3546365_+|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|239029
NZ_CP036274.1|WP_145088841.1|3546563_3547595_-|DUF1338-family-protein	unknown	unknown	gnl|CDD|319960
NZ_CP036274.1|WP_145088844.1|3547649_3548960_+|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl|CDD|223936
NZ_CP036274.1|WP_145088817.1|3533042_3539882_+|hypothetical-protein	unknown	unknown	gnl|CDD|273296
NZ_CP036274.1|WP_145088805.1|3527627_3528533_+|hypothetical-protein	unknown	unknown	gnl|CDD|226356
NZ_CP036274.1|WP_145088832.1|3543200_3544196_+|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl|CDD|380413
NZ_CP036274.1|WP_145088820.1|3539943_3540384_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145088799.1|3524976_3526095_+|muconate-cycloisomerase	unknown	unknown	gnl|CDD|239434
NZ_CP036274.1|WP_145088835.1|3544407_3544671_+|membrane-or-secreted-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145088802.1|3526225_3527764_-|MFS-transporter	unknown	unknown	gnl|CDD|340877
NZ_CP036274.1|WP_145088826.1|3540920_3541424_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145088790.1|3521077_3522109_+|succinylglutamate-desuccinylase	unknown	unknown	gnl|CDD|349470
NZ_CP036274.1|WP_145088796.1|3523375_3524731_-|hypothetical-protein	unknown	unknown	gnl|CDD|368090
NZ_CP036274.1|WP_145088808.1|3528743_3530030_-|DUF1552-domain-containing-protein	unknown	unknown	gnl|CDD|377875
NZ_CP036274.1|WP_145088787.1|3520618_3520963_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145088829.1|3541472_3543026_-|twin-arginine-translocase-subunit-TatC	unknown	unknown	gnl|CDD|376413
NZ_CP036274.1|WP_145088811.1|3530080_3530539_-|DUF1585-domain-containing-protein	unknown	unknown	gnl|CDD|377883
NZ_CP036274.1|WP_145088814.1|3530539_3532477_-|DUF1592-domain-containing-protein	unknown	unknown	gnl|CDD|377886
NZ_CP036274.1|WP_145088823.1|3540639_3540924_+|hypothetical-protein	unknown	unknown	gnl|CDD|224112
NZ_CP036274.1|WP_145088793.1|3522140_3523262_+|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	unknown	unknown	gnl|CDD|239432

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP036274.1|WP_145088841.1|3546563_3547595_-|DUF1338-family-protein	gnl|CDD|319960	cd16350, VOC_like, uncharacterized subfamily of the vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.2863e-89
NZ_CP036274.1|WP_145088844.1|3547649_3548960_+|nucleotide-sugar-dehydrogenase	gnl|CDD|223936	COG1004, Ugd, Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane].	0
NZ_CP036274.1|WP_145088817.1|3533042_3539882_+|hypothetical-protein	gnl|CDD|273296	TIGR00845, Sodium/calcium_exchanger_1, sodium/calcium exchanger 1. The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other].	2.05255e-15
NZ_CP036274.1|WP_145088805.1|3527627_3528533_+|hypothetical-protein	gnl|CDD|226356	COG3836, HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism].	5.49331e-29
NZ_CP036274.1|WP_145088832.1|3543200_3544196_+|class-I-mannose-6-phosphate-isomerase	gnl|CDD|380413	cd07010, cupin_PMI_type_I_N_bac, Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	4.34154e-78
NZ_CP036274.1|WP_145088823.1|3540639_3540924_+|hypothetical-protein	gnl|CDD|224112	COG1191, FliA, DNA-directed RNA polymerase specialized sigma subunit [Transcription].	0.0011886
NZ_CP036274.1|WP_145088799.1|3524976_3526095_+|muconate-cycloisomerase	gnl|CDD|239434	cd03318, MLE, Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived aromatics, catechol and protocatechuate, to citric acid cycle intermediates. Some bacterial species are also capable of dehalogenating chloroaromatic compounds by the action of chloromuconate lactonizing enzymes (Cl-MLEs). MLEs are members of the enolase superfamily characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and that is stabilized by coordination to the essential Mg2+ ion.	1.05782e-83
NZ_CP036274.1|WP_145088802.1|3526225_3527764_-|MFS-transporter	gnl|CDD|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.51155e-47
NZ_CP036274.1|WP_145088790.1|3521077_3522109_+|succinylglutamate-desuccinylase	gnl|CDD|349470	cd06252, M14_ASTE_ASPA-like, Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup. A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.	4.75633e-83
NZ_CP036274.1|WP_145088796.1|3523375_3524731_-|hypothetical-protein	gnl|CDD|368090	pfam04734, Ceramidase_alk, Neutral/alkaline non-lysosomal ceramidase, N-terminal. This family represents N-terminal domain of a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes. The EC classification is EC:3.5.1.23. The enzyme hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. This N-terminal domain carries two metal-binding sites, the first for Zn2+ residing within the domain, and the second, for Mg2+/Ca2+ lying at the interface between the two domains.	0.000733523
NZ_CP036274.1|WP_145088808.1|3528743_3530030_-|DUF1552-domain-containing-protein	gnl|CDD|377875	pfam07586, HXXSHH, Protein of unknown function (DUF1552). A family of proteins identified in Rhodopirellula baltica.	2.59172e-86
NZ_CP036274.1|WP_145088814.1|3530539_3532477_-|DUF1592-domain-containing-protein	gnl|CDD|377886	pfam07631, PSD4, Protein of unknown function (DUF1592). A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match pfam07627, pfam07626, and pfam07624.	2.39545e-59
NZ_CP036274.1|WP_145088829.1|3541472_3543026_-|twin-arginine-translocase-subunit-TatC	gnl|CDD|376413	pfam00902, TatC, Sec-independent protein translocase protein (TatC). The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon.	2.25986e-59
NZ_CP036274.1|WP_145088811.1|3530080_3530539_-|DUF1585-domain-containing-protein	gnl|CDD|377883	pfam07624, PSD2, Protein of unknown function (DUF1585). A conserved sequence region at the C-terminus of several cytochrome-like proteins in Rhodopirellula baltica.	2.61745e-27
NZ_CP036274.1|WP_145088838.1|3545138_3546365_+|molybdopterin-dependent-oxidoreductase	gnl|CDD|239029	cd02111, eukary_SO_Moco, molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of molybdopterin binding domains are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.	1.96777e-107
NZ_CP036274.1|WP_145088793.1|3522140_3523262_+|mandelate-racemase/muconate-lactonizing-enzyme-family-protein	gnl|CDD|239432	cd03316, MR_like, Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD).	1.43289e-107

Protein sequences

>NZ_CP036274.1|WP_145088814.1|3530539_3532477_-|DUF1592-domain-containing-protein
MWDAQRDGEMIGRLDNFIALIVIAQLGIAAVRPARAAEPLDQHVSTFFAQHCNRCHNDKKSEGELRLDQLGADLADAQIFERWQNIVGRLRAGDMPPEKEPRPPAADVTAVIRRLSARLDAAALAKRAEGRVVLRRLNRTEYENTVRDLFAVDVAVKELLPEDTIAFGFDNVGSALNVSPVLIEQYLEAADAVFTAAVLPLTKAPPAIEKHLLKDCIPSYFRGCVFEGDDTYLFRSDGNPTHISKFRPKEPGLYRCKITARAHQSDKPLTLAVLAGNFNTAAGSARRVGYYDLHQGEHQTIELVLRLAPRETIKVEPVALPRAFVKSDAFSDYPGPSINIRGVEFEGPLPETWPTESYRRMYGDIDPKQGTIEDATKTLSRILPRAFRRPTTPTDLQPYLTLVKNSLEAGKPYDESLRLGIKAILCSPRFLYLQEPAGPLDDFALASRLSYFLWSSLPDDDLFRLAAKGELRKPEVLRAQTERLLTHPKGQRFVENFTGQWLSLREIDFTTPDGQLYPEYDELLKWSMVRETELFFDELLKNDLPVLNFIDSDFAILNGRLARHYNIQDVDGVEMRRVPLAPEHHRGGVLTHASILKVTANGTTTSPVLRGVWVLDRIMGQAAKPPPASVPAIEPDIRGAVTIRD
>NZ_CP036274.1|WP_145088811.1|3530080_3530539_-|DUF1585-domain-containing-protein
MAKHRDIESCRSCHAEIDPPGFALESYDVIGGYRDNYRAIGTREKVKVPDVSYAKFLARPNYGWGPKVEAGDALKDGRKFADLAEFKQLLLADPDQVARAVTQKLMVYATGGGLQYGDQPEIERVVAKVKDQKYGLRSLVHAVVLSELFRNK
>NZ_CP036274.1|WP_145088808.1|3528743_3530030_-|DUF1552-domain-containing-protein
MLESRHSRRLFLRGAGALLALPIFEQTILRRVAQAADAKQPKEAPRRLLCINTTLGLHTENLFPKQTGKEYEPSPYLDVIKDFRNDYTVFSGLSHPDVDGGHSAEASYLTAAPHPRSDSFKNTISLDQFAVERLAPDTRFSSLVLSSSSSRGLSHTRNGVAIPAQDRPSTVFKKMFVEGTPAEVRSQVDRLSQGESVIDTVLAEAHALERGLGKQDREKLAEYFAAVRDVELRLQKAQAWAKQPKPAVEAKIPVDVTDNKEVAAKVRLMVDLMCLAFKTDSTRFITFAFSGMNAVPKIEGVSQDWHNLSHHGQDPAKLAELKIIELEQMKLFGELLAKLRATPEVGGNLLNHTTILFGSNLGNASSHSNINMPIVVAGGGYRHGQHLAFDPKKNPPLSNLYVQMLQRLGLDIDSFGSSTGTIPGFELA
>NZ_CP036274.1|WP_145088805.1|3527627_3528533_+|hypothetical-protein
MRQVFASGFSRSRCWQRVSGSPRIRFPFTRSRRTSFDSQPLPKEIMNAKLLKEKMLRGETVYGTMIQHATNPALVDFLPPGALDFVIFTAEHNALDIADFLPLRYALAAKGIVSLARTHSRDPDDVSKVCDSYDGVVVPYVEDVAHAKRLAAAAVYRPLKGAALERVLKDDKWPNARTKQYCFEERCANTLFIPMIESVEAVDNLEEICSIPGVNAVFVGPNDLTTSMGIPNEYDHPDFVAMMKRIIEIADRKHVPAGSWFGTVEQQQRTMKQGGRFVVYSNDSSMMKDAIQLAFGQMRKA
>NZ_CP036274.1|WP_145088802.1|3526225_3527764_-|MFS-transporter
MISFGRGCESNEVLLDRVKGKRILGEPLTRCQHLDRENPLAKTCLMDETTSAEPPPQPTRVRWLILLLSCGASFLLYLHRYTWNFVNPKLQGQFNLSHSQTEFLFSLFYYTYAAGQIPSGMIIDRFGPRWFLTFSILFWSLAMAALVGVSWLLGGGSSTGNLTMVIVLIGGARLLFGAAQAGCYPALTKASKVWFSPVGRTALQGLIASTAGRSGAALSSIIFGTIMMGWLGLSWQTGLLILSAVGLLYGLLFWLGYGDSPAADARVNEAERIIIRGPEELTPANAATQPAMLPWGNALRSTSLRWFICQQFCDAGSDVAFVSLIGKYFLQSRGLDLSQTGILAALPLIGGALGGLAGGALNEVSIHLSGSRRWGRSGVGFVGKVVGCLMLLTVTQQESATVAAFMLMFAKFFGDWSQPTVWGTCTDMGGRYSATVFSIINTSGTVGGVVMPLVFGRLLDVFTREVLVDDKLTKITSWDPLFYLLAGMYLASGLCWLMVDCTKSLENVAAAK
>NZ_CP036274.1|WP_145088799.1|3524976_3526095_+|muconate-cycloisomerase
MRISRIEALPIRIPLKPERRMISALGKHDVSEFTLVVVHTDDGLFGLGEATVTPRWSGETARGAQTLIEHVFTPVLLGCDPCDIEAIDARLDAVAVDNWFAKAAIEMACWDLAGKAANKPVYELLGGACRPLTIRNRFSLGAYTTEVIQPRAVALVAAGFDTLKVKVGTDPVADVVRVRAVREVIGPNIKLTIDANGGWNEAQALDCLAKLADCNLTLVEQPLPRGNYSGLKRLRERTGQKILADESCFDEVEARELIEQGCCDAISLYPGKQGGIRRSIRIANLAAEHQIPCSIGSNLEWDVGAAAMLHFIVATPNMQVELYPGDCLGPFYHEVSLAKNPLHISGPFTTINSGPGLGIELDFDVVEKHRIR
>NZ_CP036274.1|WP_145088796.1|3523375_3524731_-|hypothetical-protein
MFQAGVARREITPFWGVELTGWGYYIERRWRQIADPLFATALVMTDGEQTVVLITLDLMLIDEAFTRRTRELITGATGIPGSAIMLTCSHSHNAPAAGGLRGVGECHPLYEHLASQQAATAAILAWKSLEPARVAHAQVDVPGISFNRTRPAGVVDSQLTLLRINRVTQPGHTLAMVANYGAHPTLTTQWQPWSVSRDIPGVVCDGIEAAFPGSTALYVQGACGDANFLREYISPDRYREPAEKLIAEACDALRAAHDCEQPTVAAAQATVELPTRRWTREEIEADRREAERRMADDDIRGWRETIGRSMTNRPDDMVRRHDGDERKAVRAMCRFHLEWTELMLQDWETRPEVLPTEVQALRVGELYLVANSSEFFSPFAIEIRQRAEVPALMFACYANGRIGYLPDAHDIVAKSYAGYQSPKYCNQFPFTADSGPVMCNAMLSVIQRVKS
>NZ_CP036274.1|WP_145088793.1|3522140_3523262_+|mandelate-racemase/muconate-lactonizing-enzyme-family-protein
MKITEIVCQILRIKTVEAKTASSQDSVLVRVRTDTGLEGIGEADSSPEMVKAVIDAPFSHNIATGLRQLLIGENPLETERLWQKMYRRTMYAGRRSVPITAMAAIDMALWDLKGKHFGEPIHRLLGGKQHDKILGYASILFGRNGDETQRIAERWRAAGYHAVKFGWEPMGQSEALDLDLVRGARKGLGDDGTLLIDAGCVWDARTALQRAHSFAEYRPGWLEEALHPDDYEGYRWLRDRSPVPIAAGEEECGRQAFRPLIDGRCLDVYQVDLSRNGFTDSLYIRQRVEEIGARLCNHCYTSPVTVAASLHWLSTCRDAFLFEDCVEDSPLRHELTHEKIQTVDGWITVPDRPGLGVTLDEDFVKRTLICESR
>NZ_CP036274.1|WP_145088790.1|3521077_3522109_+|succinylglutamate-desuccinylase
MTDRQIVRPSRLDLESPGRRDYWVALEHDSIWGDHLLPLTVFVGPDSKPGEGLLATGSNHGNEYEGPVVLKHLIREINPADVLGRIILIPVLNPAAFLAGTRESTLDDGVNLNRAFVDGAGVTPALAGITHRIAAFVREYLWPRVHVVLDLHSGGEVARFAICANYHPVDDPQLARKIEETARWFGTPALMVYQNVTPGLLPSEAERLGKITVGTELGWGRAVCTEGVRYGRQGVLAAAIHNGQLRGTIEPIAHHAAGTQRKLEMVDRDCFTVAPFAGHYEPLLDCGTPVKKGQTVGLLHDFDHIDAEPWPARAGVDGVVLAQAWVSPVPRGQHIVVVGRDIT
>NZ_CP036274.1|WP_145088787.1|3520618_3520963_+|hypothetical-protein
MARKVINRRELREQSDAAEARGAGADDAEVEAVEGEEEGGKVKKKKAAPKRKSRAKSTEPARLKLFWGVFNQASKRIAKYDFTQKKQAEAKAAELSAGGKNQHFVAKVKEAVEE
>NZ_CP036274.1|WP_145088817.1|3533042_3539882_+|hypothetical-protein
MKFANERIRRRRDLHRGAAGQLSAEERARRNKLKRRNLWLESLEDRSLMATLNLVVNLYEDNAGSPGALITTDTVVPGQEFFVEITAKDTSTVPSGINGLALDVSFNSTAFEEIDSPFDPASVASPLITSAFPLFRSGTLDNTAGTIDELRGGSSQSTSMGSPIGIATFERFALLKFRADAAVSNSPLVITIGSNGVTFEDNTAFDNSPTIEAQTITVAAPALPTLSINDVTLSEGSDGTFTNYTFNVTLSEAATAAVDVQIDTVGGTATSGTDFDAITAQVLTFAIGETAKTVTVKVAADTGHEPDESFQVKLSAPVNATIADDTGTGTILNDDTVTASITKTLSLAEGNTGTTAAEFTVTLDKASSADVVIPWSFTHGTTSVSDFDSLVTTGNVTILAGQTSAKIPAFLVTGDLRVELDETFSVTLGAPVTAGVVLSADQVGTGTIENEDSAEIVITAPVAAPEGSTGNTNPEFTVTLSAPVDVDVSFNYQTQDGTAKTSGNDYVPVNGTLTFLAGNTTAQKIPVSVVSDGTVELDEQFSVLLDSLSAAGYDVTLKTATANATITNDDSATITLIPLSQVEGDAGTTNMVFEAVLSNPVDVDVTVEFNTTDGTAKLANNDYIETKGTLTFLAGGSLKQTIIVPIVGDTDVETDENFTVTLSNVAASGRDVTAGAAVNGTILDDDDTTPTISIDDVSISEDDSGETLLTFTVSLSAKSASPVDLKWSTQDGTASDASDYTAVSLQTLTIPADTLSQTITVKVQGDKLVEKDETLKVILSDITGAKSGDLEGVGTITNDDFAVASITESVIHSEGNAATTDYDFTVSLDQAASFDVVIPWSFNHTTTNAADFDGTLTTSGKVTILAGEKSAKIPSFKVVGDLSLEANETFTVGLGTPEQDEVSASVTEKTGTGTITNDDDAVVSITSQVKLNEGNSGTTDFDFAVSLDVVAGIDVVVPWSFTHTSTDAADFDGTLTTSGKVTIPAGTKSVTISPTFKVVGDKTVELEEKFLVTLGTPETAGASLSVTEQVGEGTIQNDDGIAVIVASITPTVSQSEGDAGTTNYEFTVSIDQVSATDVVIPWTFTHVDTEDSDFSAGFTKSGKVTILAGQTSAKIPAFTVLGDATLEGDESFTVTLEAPETSGVTLSSDDVGTGEVLNDDAVEVSIESKVTQNEASTGTTSYEFLVSLDQAAEVDVVVPWTFAHGTTDDDDFSPGLITSGKVTILAGQTSAKISAFSVIGDTTLETDESFTVTLDTPETTGATLNGMENVAIGEITNDDQVIVSITKNLAQAEGDSGTNDYEFTVSINQIADVDVVIPWTFAHVNSADSDFSSPPTTSGKVTIPAGLSSVKIPAFVTVGDTTVENDETFTVTLNTPETEGAVLSSTDKVGTGNIQNDDGLTASISNASITEGNSGTATIEFTVTLDQNATTDVVIPWTFDNVTTLDTDFTSLTKSGKVTIVSGSKTAKISFTVNGDTTLEGNEDFTVSLGTPETADVALSVDKVGTGTITNDDQVTVSVTKTNSQAEGNSSTKDFDFTVTLDQAAEIDVVVPWAFAHVSTNDADFTAGLTKSGKITIPAGQTSIKIPSFQVNGDTSFEGDETFTVTLNTPETAGAVLSSDKVGEGKILNDDTIVASITKTLSQNEGNSGTTAYEFTVTIDQVSSVDVVIPWNFANVTTADSDFTGALTKSGKVTIPAGQTSIKIPAFLANGDTTIEANETFTVTLGAPETAGVTLSNDDKVGTATLVNDDSATASITKTVTQNEGNSGNTAFDFTVTLDKASNVDVVIPWTMANVTTTDADFATGLTKTGKITIPAGQTSIKIPSFSILGNNIVEGNETFTVTLGTPETAGVSLSSTDSVGTGTVTNDDAATFSIGNAALLEPSTGTGDLVLPVTLSAPADVDITVSFTYTAVTTTDADFSNLTKTGTLTFLAGQTTPTTPLTFKVAADTIDETDETFTVTLGDPVFPSGVTRNVTTPSGTKVGTGTIQADSKNGVLSGWAYVDKNKNGVRDTGEVGIPGVIITLNGTTTGGAAVTLTAMTADDGSYSFTNLVGGKYSLTESHPAAMFDGIDVAGTAGGTMTNDKISDIQLDAAEQATANNFGERGLLPKFISKRLLLASTPAAAVSLRVINSRAAAIAGNQTLADQISNSSIPSVVAANPTTTANTQSAGEFIAEAPNNNNQSAGEYIDEALAQVTSQSVVPETPVVPVATPAAKVASTKTAATKAAAKTGSTSAVASKISSRSSAIQSLRSAASPSFSDTLELLALDQIAAREKKGS
>NZ_CP036274.1|WP_145088820.1|3539943_3540384_-|hypothetical-protein
MNEITFPQFAVLAPDNWFDVTAEMDEEDSPSTLAPEEGLGVLQISLADFPAQGEPPAIIEVLRTMLKEFAKAHELGSPNNLLREESPRPLLAGNFIWGDDFLRVWYLTDSGKLAFVTYTCERGAAFASELSEVEQIVRSLKFLPTV
>NZ_CP036274.1|WP_145088823.1|3540639_3540924_+|hypothetical-protein
MVADLKVPPSERDFQAFRLIKVEQRTTRAVAELLGILQTRVCQIVQRVLEFLIETAPTADDEARRAHWPRKWPRIALIFCFGWPCKVGKTRKVT
>NZ_CP036274.1|WP_145088826.1|3540920_3541424_+|hypothetical-protein
MTTSRSVGRDSRSVSTTRRNYGDVQYLSAAVRINVMAAKMTASRLPPWQAVTSESEVRPEKRRKSAAVANEPAVNHPVEDCSTRVSEQQADAPCEIIAELVSRENGTVSRAERFAFRQHRESEMRTVQEEQSDPGPAATSAAIPLNRHQRRARQRLLAKATKSKKPR
>NZ_CP036274.1|WP_145088829.1|3541472_3543026_-|twin-arginine-translocase-subunit-TatC
MFAAILLRAEHSCGDLLAPAAVTQALLAVCMLVCRRRGTIIHTGIHNGTPAMAKQPQDDLFEGGTMSFGEHLEELRICLFRSLFGVIIGCLIGLYAAEYVVVFFQGPLERALKSHYLARAIEQVKDDFDGNPPVEFQETIIKDELIPEKVSVEPAQIASVMGLSFPDYLKDSRISSSTFVPADFKEAGSELAVAKLLAEQKASKTDSPARRLWQMMSAEQQAAITKLAEVRTSFTPAERQQLIMVLNELLAQKELHDSAEFAALAGASHEATSALREAVKKEENPETTRRLNKFLVAGALADHVRSPRVNLVTFYNWKPVKVRFQVLNAQEAFMIYLKAALLTGVVISSPWIFFQIWNFVATGLYPHEKNQVFLYLPISMLLFFAGASLAFGFVFEPVLNFLFQFNQGLNAEFDPRIGEWLSFVLILPLGFGISFQLPLVMLFVNRLGLVSVDVYMKQWRMAILIIFVVAMVLTPADPISMMLMAVPLCGLYVLGIGMCIWMPQSRSPFTTAYEPSA
>NZ_CP036274.1|WP_145088832.1|3543200_3544196_+|class-I-mannose-6-phosphate-isomerase
MSSLYPLRFEPVLKRYLWGGRRLHTILGKPLPAGDDYAESWEISDHPAGQSVVTAGSLKGATLGELVANHGPALLGKHASQAAAQGRFPLLFKLLDAQKVLSVQVHPTDAAAAQLTPPDLGKTEAWVVLHAEPGSVVYAGIKRGFDRATVERELLSGTVELCLNKFEPQAGDCLFIPAGVVHALGAGLVIAEIQQASDTTFRLYDWKRVGPDGQPRPLHIQQSLAAIDFAHGPVQPQKPTVVPHADGTAQIEQLVSCDKFVLERWTISGPTKIGGDDRCYLLCAIDGELSISNDPSQKPLARGQSALLPATSPALLTPRREATVLVASLPG
>NZ_CP036274.1|WP_145088835.1|3544407_3544671_+|membrane-or-secreted-protein
MRTTYILMLLALLLVPNVGCAGNRFAASRWNFWHPGPTTQQRVRASVHDPYSDRDLGPEVVGGRPREFMNQYPEAVRNRFYSDTNAR
>NZ_CP036274.1|WP_145088838.1|3545138_3546365_+|molybdopterin-dependent-oxidoreductase
MNSSLTSMKIVRSTRRLWLAQTAALGATAYLGSTGWGQDSATQAAGSKLIVRQERPFNAEPGLPELVKNYFTPVEQFYVRSHGDVPTVDEKTFRLKISGLVNRELEFSVDQLKEKFDTHKVAATLTCAGNRRQEMSAIKKVAGVQWDAGAIGHATWTGALLSEVLKAAELKPEAKHVWFDGLDPIKEKDGSEAPFGGSIPLGKALAHEGRDLPSLLAHSMNDKPLTPAHGAPLRSLVPGFIGARSVKWLAKIVVSDRSSPNHYVAEAYKLIQTDDKEEVAKAEPIYEFPLNVAIGLPTDGVKLKAGRQEISGYVLPSGTPNSFCQEIELSVDNGRNWRSVKTLASDPITAASTFSWRLWTANVDILKGRQTLIARAVDTAGKSTPEQGPWNLKGYMYNAWHRVRVEGV
>NZ_CP036274.1|WP_145088841.1|3546563_3547595_-|DUF1338-family-protein
MVWRTIQRRALLLPSEFSILPAEDFTMTAISGPHERLAGDANREQFLAAVFDALWERYRSRVSYVQTYEKVVHEAGATFFNDHIAFRTLAVQQPQAGIASVSRVFEALGYRAAGSYHFEDKQLSAIHFQHPNVQFPKLFVSELKTWELPAESRSLIELALAAHRPQLRNDLLAELAGLDQSKPTDSHRDLLMTEVVDWFHTLPWKAPEKAAVQKLNAVSQYGAWTLVHGYNVNHFTSLVNSHGVPQLNDLEKTMQALAAAGVPIKTEIEGERGSKLRQSATEAVKIDVDVREGATNTKLPWSYAYFELAERNEITDAATGNKVRFEGFLGPQATNLFEMTRLK
>NZ_CP036274.1|WP_145088844.1|3547649_3548960_+|nucleotide-sugar-dehydrogenase
MKIAMIGAGYVGLVSGTCLADTGNEVTCVDINQDRIERLEQGQVPIYEPGLAELVVRNAALGRLHFTIDTAEAVRSAQLVFLAVGTPSNEDGSADLSYLWQAVEKIAPHLRTDAVVVVKSTAPVGTNQEISNRLRKLTGRECDVASNPEFLKEGAAINDFQYPDRIVVGVRTPAAEDKLRELYAPYLRTDKPFLTMTPESAELTKYVANALLSTKISFINEMANLCERLKGDINDVRRGIGHDRRIGFQFLFPGVGYGGSCFPKDVRALADMARKVGLEPRMLDAVDTVNNHQKFVLLAKLKQQFSDKLQGLTIAIWGLAFKPRTDDIREAPALVLIDQLLAAGCKVQVHDPEALKNVQALYGDKLLYATSPLDALEGADALCINTEWGDFRNPDFDEMKRRLRLPIIFDGRNLYEPETMREYGFVYHSIGRVPVK

Crispr_ID: NZ_CP036274_4

• CRISPR_ID: NZ_CP036274_4
• CRISPR_location: 5088583-5088816
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP036274_4

Consensus_repeat	Method
CGGCAACGACACGCTNAC	CRT

spacers of NZ_CP036274_4

>4.1|5088601|36|NZ_CP036274|CRT
CGGTGGCAGTGGCCCGACGACCCTCATCGGCGGCAT
>4.2|5088655|36|NZ_CP036274|CRT
GAGTGGCAACGGCACATCAACACTTTACGGTGGTGA
>4.3|5088709|36|NZ_CP036274|CRT
CAGTGGCAACGGAGCAGCACTTCTATTCGGCCAAGC
>4.4|5088763|36|NZ_CP036274|CRT
CAGCGGGAAGGGAATTGCTGTCCTGGTGGGCGGTAC

CRISPR arrays and Neighbor proteins around NZ_CP036274_4

CRISPR arrays

The CRISPR arrays of NZ_CP036274_4

>merge|NZ_CP036274|4|5088583-5088816|CRT
CGGCAACGACACGCTGACCGGTGGCAGTGGCCCGACGACCCTCATCGGCGGCATCGGCAACGACAAGCTCACGAGTGGCAACGGCACATCAACACTTTACGGTGGTGACGGCAACGACACTCTCACCAGTGGCAACGGAGCAGCACTTCTATTCGGCCAAGCCGGCAACGATACGCTCACCAGCGGGAAGGGAATTGCTGTCCTGGTGGGCGGTACCGGCAACGACACGCTGAA

>NZ_CP036274|4|1|5088583-5088816|CRT
CGGCAACGACACGCTGAC	CGGTGGCAGTGGCCCGACGACCCTCATCGGCGGCAT
CGGCAACGACAAGCTCAC	GAGTGGCAACGGCACATCAACACTTTACGGTGGTGA
CGGCAACGACACTCTCAC	CAGTGGCAACGGAGCAGCACTTCTATTCGGCCAAGC
CGGCAACGATACGCTCAC	CAGCGGGAAGGGAATTGCTGTCCTGGTGGGCGGTAC
CGGCAACGACACGCTGAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036274.1|WP_145091773.1|5098762_5099197_-|hypothetical-protein	unknown	unknown	gnl|CDD|379169
NZ_CP036274.1|WP_145091748.1|5089837_5090626_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145091739.1|5069186_5072798_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP036274.1|WP_145086466.1|5066288_5067110_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|224401
NZ_CP036274.1|WP_145091771.1|5098093_5098621_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145086469.1|5064777_5066292_+|IS21-family-transposase	unknown	unknown	gnl|CDD|226950
NZ_CP036274.1|WP_145091736.1|5068590_5069166_+|RNA-polymerase-subunit-sigma	unknown	unknown	gnl|CDD|132044
NZ_CP036274.1|WP_145091762.1|5095177_5096317_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145091730.1|5060840_5063375_-|DUF1588-domain-containing-protein	unknown	unknown	gnl|CDD|377885
NZ_CP036274.1|WP_145091765.1|5096553_5096877_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145091732.1|5064311_5064701_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145091742.1|5072886_5075178_-|hypothetical-protein	unknown	unknown	gnl|CDD|367364
NZ_CP036274.1|WP_145100712.1|5057784_5059329_-|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl|CDD|293755
NZ_CP036274.1|WP_145091760.1|5094323_5094659_+|transposase	unknown	unknown	gnl|CDD|372671
NZ_CP036274.1|WP_145091754.1|5091682_5092759_-|transposase	unknown	unknown	gnl|CDD|372671
NZ_CP036274.1|WP_145091768.1|5097312_5097771_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145091734.1|5067270_5068302_+|hypothetical-protein	unknown	unknown	gnl|CDD|368649
NZ_CP036274.1|WP_145091728.1|5059434_5060844_-|DUF1552-domain-containing-protein	unknown	unknown	gnl|CDD|377875
NZ_CP036274.1|WP_145091757.1|5092886_5093306_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145091751.1|5090999_5091323_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP036274.1|WP_145091739.1|5069186_5072798_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.83031e-99
NZ_CP036274.1|WP_145086466.1|5066288_5067110_+|AAA-family-ATPase	gnl|CDD|224401	COG1484, DnaC, DNA replication protein [DNA replication, recombination, and repair].	2.68518e-69
NZ_CP036274.1|WP_145091754.1|5091682_5092759_-|transposase	gnl|CDD|372671	pfam13683, rve_3, Integrase core domain.	1.39479e-10
NZ_CP036274.1|WP_145086469.1|5064777_5066292_+|IS21-family-transposase	gnl|CDD|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	7.90392e-27
NZ_CP036274.1|WP_145091736.1|5068590_5069166_+|RNA-polymerase-subunit-sigma	gnl|CDD|132044	TIGR02999, Sig-70_X6, RNA polymerase sigma factor, TIGR02999 family. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found in a variety of species including Rhodopirellula baltica which encodes a paralogous group of five.	7.5806e-43
NZ_CP036274.1|WP_145091730.1|5060840_5063375_-|DUF1588-domain-containing-protein	gnl|CDD|377885	pfam07627, PSCyt3, Protein of unknown function (DUF1588). A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match pfam07626 and pfam07624.	5.49447e-39
NZ_CP036274.1|WP_145091742.1|5072886_5075178_-|hypothetical-protein	gnl|CDD|367364	pfam03160, Calx-beta, Calx-beta domain.	4.06482e-12
NZ_CP036274.1|WP_145100712.1|5057784_5059329_-|sulfatase-like-hydrolase/transferase	gnl|CDD|293755	cd16031, G6S_like, unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS). N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.	0
NZ_CP036274.1|WP_145091760.1|5094323_5094659_+|transposase	gnl|CDD|372671	pfam13683, rve_3, Integrase core domain.	0.00515536
NZ_CP036274.1|WP_145091773.1|5098762_5099197_-|hypothetical-protein	gnl|CDD|379169	pfam13408, Zn_ribbon_recom, Recombinase zinc beta ribbon domain. This short bacterial protein contains a zinc ribbon domain that is likely to be DNA-binding. This domain is found in site specific recombinase proteins. This family appears most closely related to pfam04606.	1.09004e-10
NZ_CP036274.1|WP_145091734.1|5067270_5068302_+|hypothetical-protein	gnl|CDD|368649	pfam05876, Terminase_GpA, Phage terminase large subunit (GpA). This family consists of several phage terminase large subunit proteins as well as related sequences from several bacterial species. The DNA packaging enzyme of bacteriophage lambda, terminase, is a heteromultimer composed of a small subunit, gpNu1, and a large subunit, gpA, products of the Nu1 and A genes, respectively. Terminase is involved in the site-specific binding and cutting of the DNA in the initial stages of packaging. It is now known that gpA is actively involved in late stages of packaging, including DNA translocation, and that this enzyme contains separate functional domains for its early and late packaging activities.	5.61293e-20
NZ_CP036274.1|WP_145091728.1|5059434_5060844_-|DUF1552-domain-containing-protein	gnl|CDD|377875	pfam07586, HXXSHH, Protein of unknown function (DUF1552). A family of proteins identified in Rhodopirellula baltica.	6.54498e-23

Protein sequences

>NZ_CP036274.1|WP_145091742.1|5072886_5075178_-|hypothetical-protein
MSRSYRPVSFRPTISISKGQLSSRKSLVIERLETRDLMSASPLTSDTEGIAIYGPVPLAESMEVCRLTEALLAAPGPTHEDSAHTFPDSNHSAAGLLATGRIYDDANGNSVLDLNERSLPNAKIYADLNNNLVQDVNEPFGYSGAEGVFGLFGVPAGVYPLRVDRPGWETTQEGHFDSQELGNILLGIHSTADLPVGNVSGTIFRDLNLDGLRNPNEVGLRDRTVYADDNENGIADPSETSARTDAAGNYELQLTAGEHLVREVGNASDPILVTLAEGETTACADIAIRPGGALAGSVYHDRNASGMRDRDEEALPGQVYLDINQNCQFDAGEAFSDVDSNGAFQFADISAGEYILRALFAPGTQVSEGASGQMISLSEGDEIRDILFGGYRNASISGLVVHDYNTLWGNGVAGQQVFVDVNDNGNLDFDEPVAISDENGGFYTLEGLTPGVYQLRLANTAGWHATDESRGEAVTVTSGEVKTINPLRVQPGLEILDAQVSEGSEATGYATFVVHLQTPVEVPITVSFKTSAALQPTSPATGIAKAGQDYLAGIGTLTFAPGEQSKSIRVRVLGDTVAENDEQFIVQLQNPRGATLIRNEATGSIIDDDAAAQDPSGTPAIEPCVTGEIESAAPVMSVASAATSSATLNLKGVVPSYNPNGGTKKILGGATLTNSRQITASFRADFYWSSIPSLNAGARSELIGSTNIAGKSFATGNHSIGFSLNTQRSLVKPAYAKYLVQVLVPGAGMQESTYLDNVTAAKL
>NZ_CP036274.1|WP_145091739.1|5069186_5072798_+|protein-kinase
MRMSPVTQANDVRRYFDLAAELPIEDQQTFLARECGDPIVRRRVLDLLAVDQISAADQTTTEQQVPQTRSDSQPRPALAVPGFEIVDQLGEGGMGIVFLARQISLKRWVALKMVRAGTYADAKVLSRFQSEAEAVAQLQHPHIVQIYDIGSIDGHPYFTMEFIDGPTLAARIAGRPQPVEEAISTLIALSQAIQFMHQRGILHRDLKPANVLLASSGPKIADFGLAKNQSNEAGWTQTGAVFGTPGYMAPEQASGNHEAIGPATDVYALGVILYEMLTGTIPFRGKTTAETLELVRNHDPVPPSRFGQRLSRDLETICLTALAKEPQRRYASAAAFAIDLQLLQAGEPIRARRERVTDKIVRRLRRSPAFYGAILIAAFGLLFAGVAGWNNRQTQAENRLRQTIQERLAGDDLLETDVVALEKLIGQLAETAPSDGLKHRDALGRRLAELITDHLGHERLEKADFAAIESKLKLLKNRLPSVADELSMRMNERRVQLQRVVELQAPFAEIPPVLSGTHLVTTDGTLTNDPKDSKGSAVVLTTEPCIGNLRCEVTLWLANPQEPFSAGILLNAHQEGTKSHAFVVTRAGQVTMASIVRNGVVQRQMEIQLSSPILRIMAERDGETLALQVLSNDQPLGKLTFQDVFAIAGSNAGNFAIAWPRRARLEAFSAWRQSLSFAASSLERGDNEYEHGNFKVAVEDYRHVAETNQDSRVRDEAKYKEALCLLGLGNEHEAERLFTGIATGRGNPRWVLLARIQLVMLCVQANRVDEMQEWLESLRAEFGLEQIASLVPHATRMRIRDAYRVSGGLEFLRPDPKRTTKLEQGILLDELCDITIAQRYLTQRMLLRAYHADGKYAQALELAERMSSEFAQMDDPHFYEEYMWLLCLQDRVTQAKKASADWLRKGHQDQVALLAAVRLDVKLGNWDQAAARIDEYFLRFPQSDSSHPNDVGAAWLMRGLLLDRKGETDAARQTWRKGYLAMKEAERHWEHRSHNLHTLYKVVLGSLSDSLSDADEDVIVTSVVFGGNTAFSVLRGTFQLPAGSLRKAWQTSRGKEAAMDLGFFRVGFDDLFQTSLVVVALSVACDGIHEEAWSPDLEEHLWQAGRSLVQSFLAGKHSTAQLLQLALAWKGNTSVIGWSGISPSLSPVIRGPLALALGHRFQKLGRVQDSRMFFESAAADAMTTNNDELQRLAEQGRQQTIPK
>NZ_CP036274.1|WP_145091736.1|5068590_5069166_+|RNA-polymerase-subunit-sigma
MADVGAITLLLRRIRDGEPQLIDELVAQIYQGCVQRAHLLRRGERPGHTLQSHDLADEGLMRLIQGNEVTKAADRGQLFWAFSRAVRQVLVEHARRRNAGKRGGDAVRVPLDEVLDSLQQKCQSDVVNLDEAIQVLAREYPEEGKVLEMHYFGEYSLPEIAQSLDVSLSTIERRHRFAKAWLRDWLKDQSI
>NZ_CP036274.1|WP_145091734.1|5067270_5068302_+|hypothetical-protein
MQNEAAFFAEYQNEPLPEAVPFSTLLSAEEIAAKLNRLPRATVPSSCTQLTAYIDVQGNLLYYLVCAWTEDFSGYVIDYGCYPDQRRDYFTLRDANPTLLSVAPGTAQEGAIFAGLQGLTADLLGREWQQDGGGILRIGACLIDANWGASTDTVYEFCRRSTFGGVLMPSHGRYVGAASVPFAEYKRQPGERVGHNWRIPSTYGKRACRHVTYDTNYWKTFVFARLTVAMGDRSCLSIFGTEPNRHRLLSEHITAEYPVTTQGRGRTVEEWKARPNHPDNHWFDCLVGNAVAASMLGVHLETGTKIERKRISLRELAERPTARQLAEQTARKQATIPEHMRRR
>NZ_CP036274.1|WP_145086466.1|5066288_5067110_+|AAA-family-ATPase
MKSLETKSTVLLKHHLKALRLPSFLEGCEKTAQRCATENVDHLGFLLQLCELELLNREKRASERRLKSARFPNLKSPGDFDFAAQPSLNRVLVAELLRCEFVERRESVIFLGHPGTGKTHLAIALGIAACQRGKRVRFCRVTELITQLMEAREERTLLRMKSSLAKFDLLILDELGYVPASKLGAELLFEVISSAYERQSLIVTTNLPFEQWTEVLGSERLTGAVLDRLTHRCHILESTGESYRLQDARRRRKGSRPKPATSSLSPADETAES
>NZ_CP036274.1|WP_145086469.1|5064777_5066292_+|IS21-family-transposase
MLRDMHNWTEIRRLVLTEKKSKRAVCREFSLHWQTLEKILQHPEPPGYRQRLPRERPKLDPFLPIIHEILEQDKTAPRKQRHTTKRIFDRLRAEHGYTGGITVVGEVVREWRTTTAEVFLPLSHQPGEAQFDFGEAEVVLQGMPTKVAYCVMSLPYSDAFFVQVFPRECTETFQAGHQRAFEFFGGVPRRISYDNSRIAVARFVGKRGDTPTREFLRLQSHYLFEHHFCLVRRPMEKGHTENLIGFARRNFLVPVPRTGSLEVLNAELERQCCEDLERQLRGQPANKATLLAEEQAALLPLPKSGFEARRVEPAQANSLSLVRFDGNDYSVPTQYAHQKVTAIGGLEEVRLVVNDKLVAQHPRDWSKEQVHYNPLHYLALLERKPGGLDFAKPLENWGLPDCFDLLRRRLEADGGAHGRREFIKTLRLLETISLAALTAAIERALEIDVLAVDAIRLLVQQGLEEPTRWFRLDNHPHLQSHSIPPPNLLSYRELTCALTTGGVL
>NZ_CP036274.1|WP_145091732.1|5064311_5064701_+|hypothetical-protein
MKAWIQRKKDAYHLRVVIDGKEHQRSLGKVNANSAQATLGTVCGVIDQVERGQLAVPSDVSPIEFMLNGGKRAAPTLAKLTISESKGLYLASESEEAAVTYLGSQTTHVNDGRIVQRAAEPMVGRKVQR
>NZ_CP036274.1|WP_145091730.1|5060840_5063375_-|DUF1588-domain-containing-protein
MRYSYFLLACCLALLPAVVHAQAQESIAIPPHVSQAFLRYCGECHGNETSEADINLAKLVTLETSEQLELLNRVQDQLFFRTMPPTDSRQPSEEDRTSLVNWLRGELRKHGASKLDEKLRYPAYGNYVEHELLFGGKVKAAAFTPARRWLVSPQIFTERVLDVFQLQGRERDSFRLQGFAGVTNPFVLPDQSGVRYYDQGTLDGGTLLVMLGNAQWIADKQLRAARVKHGELDANEFENVRDRWYPKTTPPALEAIVLKNEAPTDAELTAAIQSQFACVLQRAATADELRKYVALTRDAIQLGGNSAGLRQMLVTVLLESEFLYRLEFGAGQPDENGRVRLAPREASLAIAYALGDRGPDAILLQAASEGRLNTREDYRREVERLLADKTYFQAPVDPSLNGKHIQSHVVSHPKLVRFFREFFGYTGALKVFKDSPRSGGYYQNADRGHTGTPGWLIQEADELVIWCLDQDQKVFENLLTTDQFFVFHNLDTKAGQACIAEWREVYEKLQGTPWKTEPEQVMADHRQLLGAAKIIDAREKELWKQKRSFLSYMYYFQDTFGRGTIPFTRGPFTHGYSYTHSQSYSLPPLPTRDRYIGVETDRYKEPSDKPMYWSYPVEQPFQIANRKGLLTHPAWLVAHSSNFHTDPIRRGRWIREKLLAGRVPDVPITVDAQVPDDPHKTLRQRVEIVTHNTECWKCHQHMNPLGLPFESFDDFGRFRTQESREHPENLVRKGNGKDVADVYQTSPIDSSGVLSGTGDANLDGEVPDAFEMIDRLARSERVRQSIIRHAFRFFLGRNEMPSDAQTLIDADQAYVSSDGSFRAVVVSLLTSDSFIYRKPIQDQP
>NZ_CP036274.1|WP_145091728.1|5059434_5060844_-|DUF1552-domain-containing-protein
MTTTRRQFNTQALLGTGALALLPQTLLADTALAKPPMRFIFLHRGNGLFPRVLVPPTFSKELKDKEQQKAGFEVDLDKHDLPAWLSPLSAHKENLTLLQGLSGKMCTTGHHSWCSSLGVFKANERVSSIRWATVDFELAKMFPSPLEHIELACFPLDGGNPRGSLNGIAQGFSARGPQQPNYAFGSPRVALQELFKSVATNADERIRYQLERKVLDFVARNEASRLSTVAGAEQAKLKRYSDALDAVQERNRRVDLMTEVLRQHTPKLADKYLNDEMTTLDRQAGHVEVLLAALISGLTNVVAFTIDELGHHYTGIPGLETEKVNMHDIGHGKAMGGVPAEEIRSRCEQYHMTLVDRIVTRLKSVREGDGTMFDNTMLLYFPDSGETHHSVGLEFPFVVLSGRNCPLNIARRYIRMPNYGQPGHKTLGNWYTTILNAFGNPIPHYGDLDTGLAKYHIDQKGPIKSFLQL
>NZ_CP036274.1|WP_145100712.1|5057784_5059329_-|sulfatase-like-hydrolase/transferase
MAAADKPNILFIFSDDHAQHAISAYGSKVNQTPHLDRLAKAGARFTNSFVTNSICTPSRATLLTGQYSHLNGVPVFNRFDGGRDHAAKHLQAGGYHTGMIGKWHLGSDPTGFDRWIALPGQGAYWNPQFLLPGKKKLTIEGHCTDITTDLGIEWMKTRPKDKPFFLMLHQKAPHRAWEPAKRHLEMFKDKLIPEPETLFDDYATRPTALPKNQQTVARNLTRRDLKLMPPADLKGPALQKWLNTSPTELEVDGKTLTGKELVQWKYQKYMRDYLGCVQGVDDGVGKVLDYLDEAGLAENTIVIYSADNGWYLGDLGLYDKRFMYEPGLHVPLIVRGPGVTKGSVPAQFVANIDLAPTFIDLAGLPVPEFMQGRSFAPLLRGESPADWRTTMYYRYYHDPGHHNTAAHLGVRTATHKLIHYWKQDAYELFDLTADPHEQRNLLHSPADAQQPAVAAKFTELRAELARLQQQYKDTDDLYADPTTWPAGSADGPWDAYQVTGNKTVAEAIQAAVQH
>NZ_CP036274.1|WP_145091748.1|5089837_5090626_-|hypothetical-protein
MLPSDHCFERFVSPLSNPFYFEDPRSLTEVRGIFLDNNLPAAIGGGDLQVEALQLRGRLTERWSVVMARLANINVNQPGGPAGLLSVPIGVKYNFVRDVECQRLLTVGLTYFIPGSAQPLPPPGGGDFHIYLSGGTQLGDCGHWLSATGLRLPADNFLGTQLWYWSNQWDYEVRENWYAVAGVNWFHYLSNSGAGFTGDIGGLDLLNLPAATVAGNDFVTGVVGGKWKPTEHWELGLGYEFPLTGAADILRDRLYVDVVLRY
>NZ_CP036274.1|WP_145091751.1|5090999_5091323_-|hypothetical-protein
MADGAPGVQKRMHSHHSLRQIQCNSMTNVFQSLLLVIAGATQKELARQVKYLKVENQILRSKLPKRITFTPKERVRQVKFAQKLGGKVLRQLTPIVARPPSWVGYIN
>NZ_CP036274.1|WP_145091754.1|5091682_5092759_-|transposase
MKNLFQPLLLLIAGATQKELARQVRYLKVENEILRSKLPSRVIVTEKEKNRLAKFAAKLGSAINELVSIVHPDTLRRWIRALNQTVKKTVAKRGRPKTNAEIRELILKLARENDWGYTRIIGELKKLGITPPSRNTIKNILKEHGLDPGPKRGEGTWDEFLTQHARTLWQCDFFAKSALTMKGFRDLYVLVFLHVETRRVWISPSTFHPDETWVKQQAVAFLEHSKQIELPPKLLMHDRDTKFTKAFDAIFDAAGAEGKQTAFRSPNTNAYVERFIQTLQQEVLDHFVVFGEQHMDHLVSETVEHYHEERPHQSLGNEPPVNHQTTETTGSDTDETKLRIVCRERLGGRLKHYALRAA
>NZ_CP036274.1|WP_145091757.1|5092886_5093306_-|hypothetical-protein
MVNAVKVARKYQTFLERPEVLGYQQAAKKFGVSKPVISTYLAILNRLPTSFVEWLENCPDKLVVAFFSERRLRPVTRIEGDQEKVNVLRALLNQCLGELEEENQALERLRALLETEVTPSDSEDSSFPPPRAFRAIQLD
>NZ_CP036274.1|WP_145091760.1|5094323_5094659_+|transposase
MIESWWRVLKHQWLYLNRLDTRATVQKLVAFYVEQHNKHLLHAAFHGQTPDEMYFGTGADISKQLAAAKVAAAKVAAAKVAAAKVAARQARLAGNRAVRCQSCSEPVAISN
>NZ_CP036274.1|WP_145091762.1|5095177_5096317_+|hypothetical-protein
MPVTVTRTSLQVQNWNGSINKATDIVGMNGVGLNIELEAHASGGDELPPSIKVQLEFKEASQAGTGKASWSGKPVLDVPRHAYTSYYRFDVPWQIWSMLGVAEGRREFATVVRYSSDDMKATADGAFRSQLVYGNWADRGMAQQSLRMSNNSGDARLRRPDAKQLMLAGGVEILEIKVLPQPHLKVKDGSTYCFMRSPADVFFYTGHGLGGNLVTHGGPGEGLHDDFMTPEELLQAWTVTNPILGPKSLDVDVLIINGCSVLNCDDKDGTGKKWARLLMNQEGPLYSILGYRDGAPADSNGGHAVAAAMGKAIIGNLDSKWMAYAKTWLEINKQNHKHYRPTSSNYSLANACAIDLNGYWYLEELDDELHIIGPKKLPK
>NZ_CP036274.1|WP_145091765.1|5096553_5096877_+|hypothetical-protein
MASHLFNEWKQQLLRDYLASTDDIRIALLMTLLRVTTFGTFVREFSPPNPKKGGWPEIPPSDSASDPYCRNALSSFKNGHIAFTHTWGGENSRIKLHNVVTHSTADF
>NZ_CP036274.1|WP_145091768.1|5097312_5097771_+|hypothetical-protein
MKIAIAIIVVVVVVTIVVVILAKRRSPDAELTPAKKIMPATQVMPPGEISYSQLDITETFGDNERLKSDEWISTSPLNKMTPKGEASGLPPADATADEVYAVADKMSRIRESISIPNDGVYCPICHIANVQLGKLRSPCPKCGRPLLKFGWD
>NZ_CP036274.1|WP_145091771.1|5098093_5098621_+|hypothetical-protein
MSISAEGTHMAHPMDLRELLEARDGRPTEYQAARKIATFAVIPAAMVGLLAGTQLVDIADPIGRLLWVCTATALVSGFGIAFLVLGVYYLFGFRPLAVLADALVGGFIGLLCGAALTMSLISLKVVPRAYSLCPLVLIPFGAVAVPLFRAWRGATRERETVGQDAASEAVKGSRE
>NZ_CP036274.1|WP_145091773.1|5098762_5099197_-|hypothetical-protein
MFEQIRQAIASRRSRPPGRTTAAIEWPLRGLLICGSCGRGMSPSISGYKTLRYRYYRCRSRAFGRPPCEDVGISAFEIEEFVRDTLTSATTSQEFMSVWSHLDKRQQVKALKNVLKEVRFDPQGESISLTLHTDAVERLKRHRN

Crispr_ID: NZ_CP036274_5

• CRISPR_ID: NZ_CP036274_5
• CRISPR_location: 7251412-7251489
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP036274_5

Consensus_repeat	Method
CGTGGAAATTTCCACAATCCATC	CRISPRCasFinder

spacers of NZ_CP036274_5

>5.1|7251435|32|NZ_CP036274|CRISPRCasFinder
TGAATAAGCTTCGCGCAGTGGCTGCAACGCCA

CRISPR arrays and Neighbor proteins around NZ_CP036274_5

CRISPR arrays

The CRISPR arrays of NZ_CP036274_5

>merge|NZ_CP036274|5|7251412-7251489|CRISPRCasFinder
CGTGGAAATTTCCACAATCCATCTGAATAAGCTTCGCGCAGTGGCTGCAACGCCACGTGGAAATTTCCACAATCCAAT

>NZ_CP036274|5|4|7251412-7251489|CRISPRCasFinder
CGTGGAAATTTCCACAATCCATC	TGAATAAGCTTCGCGCAGTGGCTGCAACGCCA
CGTGGAAATTTCCACAATCCAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036274.1|WP_145096291.1|7255822_7257919_+|glycogen-debranching-protein-GlgX	unknown	unknown	gnl|CDD|200465
NZ_CP036274.1|WP_145096261.1|7240118_7241060_-|hypothetical-protein	unknown	unknown	gnl|CDD|379468
NZ_CP036274.1|WP_145101017.1|7249709_7250234_+|chemotaxis-protein	unknown	unknown	gnl|CDD|381733
NZ_CP036274.1|WP_145096310.1|7262175_7264455_+|DUF1549-domain-containing-protein	unknown	unknown	gnl|CDD|377872
NZ_CP036274.1|WP_145096294.1|7258149_7258824_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145096267.1|7241415_7242414_-|hypothetical-protein	unknown	unknown	gnl|CDD|271326
NZ_CP036274.1|WP_145101013.1|7243694_7245719_+|PAS-domain-containing-protein	unknown	unknown	gnl|CDD|214599
NZ_CP036274.1|WP_145096276.1|7250297_7250789_+|chemotaxis-protein-CheD	unknown	unknown	gnl|CDD|319352
NZ_CP036274.1|WP_145096288.1|7255121_7255496_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145096264.1|7241158_7241407_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145096282.1|7251799_7252942_-|redoxin-family-protein	unknown	unknown	gnl|CDD|239264
NZ_CP036274.1|WP_145096307.1|7261331_7262072_+|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl|CDD|376615
NZ_CP036274.1|WP_145096279.1|7250841_7251210_+|response-regulator	unknown	unknown	gnl|CDD|381097
NZ_CP036274.1|WP_145096298.1|7258820_7259288_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145096304.1|7259841_7261332_+|radical-SAM-protein	unknown	unknown	gnl|CDD|224875
NZ_CP036274.1|WP_145096273.1|7246692_7249593_+|hypothetical-protein	unknown	unknown	gnl|CDD|223716
NZ_CP036274.1|WP_145101010.1|7243013_7243490_+|chemotaxis-protein-CheW	unknown	unknown	gnl|CDD|238374
NZ_CP036274.1|WP_145096285.1|7253210_7255112_-|sodium:proton-exchanger	unknown	unknown	gnl|CDD|182633
NZ_CP036274.1|WP_145096301.1|7259324_7259819_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP036274.1|WP_145096270.1|7245827_7246667_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|224271

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP036274.1|WP_145096291.1|7255822_7257919_+|glycogen-debranching-protein-GlgX	gnl|CDD|200465	cd11326, AmyAc_Glg_debranch, Alpha amylase catalytic domain found in glycogen debranching enzymes. Debranching enzymes facilitate the breakdown of glycogen through glucosyltransferase and glucosidase activity. These activities are performed by a single enzyme in mammals, yeast, and some bacteria, but by two distinct enzymes in Escherichia coli and other bacteria. Debranching enzymes perform two activities: 4-alpha-D-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33). 4-alpha-D-glucanotransferase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-alpha-1,6-glucosidase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. In Escherichia coli, GlgX is the debranching enzyme and malQ is the 4-alpha-glucanotransferase. TreX, an archaeal glycogen-debranching enzyme has dual activities like mammals and yeast, but is structurally similar to GlgX. TreX exists in two oligomeric states, a dimer and tetramer. Isoamylase (EC 3.2.1.68) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen and their beta-limit dextrins. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
NZ_CP036274.1|WP_145096261.1|7240118_7241060_-|hypothetical-protein	gnl|CDD|379468	pfam14100, PmoA, Methane oxygenase PmoA. This family is a putative methane oxygenase.	3.05226e-79
NZ_CP036274.1|WP_145101017.1|7249709_7250234_+|chemotaxis-protein	gnl|CDD|381733	cd17905, CheC-like, chemotaxis protein CheC; includes CheC classes I, II, and III. This family contains chemotaxis protein CheC that acts as a weak CheY-P phosphatase but shows increased activity in the presence of CheD. This CheC family includes three classes: class I containing Bacillus subtilis CheC which might function as a regulator of CheD; class II CheCs that likely function as phosphatases in systems other than chemotaxis; and class III CheCs that are found chiefly in the archaeal class Halobacteria and might function similarly as class I CheCs. Class I CheCs contain two active sites with the consensus sequence ([DS]xxxExxNx(22)P), with four conserved residues thought to form the phosphatase active site; class II and class III CheCs have only one actve site.	9.49442e-57
NZ_CP036274.1|WP_145096310.1|7262175_7264455_+|DUF1549-domain-containing-protein	gnl|CDD|377872	pfam07583, PSCyt2, Protein of unknown function (DUF1549). A family of paralogues in the planctomyces.	2.19939e-62
NZ_CP036274.1|WP_145096267.1|7241415_7242414_-|hypothetical-protein	gnl|CDD|271326	cd14956, NHL_like_3, Uncharacterized NHL-repeat domain in bacterial proteins. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.	3.03537e-99
NZ_CP036274.1|WP_145101013.1|7243694_7245719_+|PAS-domain-containing-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	2.7156e-67
NZ_CP036274.1|WP_145096276.1|7250297_7250789_+|chemotaxis-protein-CheD	gnl|CDD|319352	cd16352, CheD, chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins. This family contains bacterial chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). The CheD chemotaxis gene is not found in the Escherichia coli genome, but is present in many other organisms, including B. subtilis, where CheD appears to have two separate roles; it binds to chemoreceptors to activate them as part of the CheC/CheD/CheYp adaptation system, and it deamidates selected residues to activate chemoreceptors, enabling them to mediate amino acid chemotaxis. CheD has been shown to catalyze amide hydrolysis of specific glutaminyl side chains of the B. subtilis chemoreceptors McpA, McpB and McpC; deamination by CheD is required for the chemoreceptors to effectively transduce signals to the CheA kinase. CheD's ability to bind the receptors is controlled by CheC via a competitive binding mechanism; substituting Gln into the receptor motif of the signal-terminating phosphatase, CheC, turns the inhibitor into a receptor-modifying deamidase CheD substrate. Also, CheYp increases the affinity of CheD for CheC, controlling CheD binding to the receptors through its interactions with CheC. Thus, high levels of CheYp means CheC is a better binding target for CheD than the receptors, resulting in decreased CheA activity. The CheD structure reveals a distant homology with a class of bacterial toxins represented by the cytotoxic necrotizing factor 1 (CNF1) as well as a class of proteins of unknown function represented by B. subtilis YfiH. An invariant Cys-His pair forming a catalytic dyad is observed, and is required by the toxins for deamidation activity.	5.58325e-49
NZ_CP036274.1|WP_145096282.1|7251799_7252942_-|redoxin-family-protein	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.39377e-23
NZ_CP036274.1|WP_145096307.1|7261331_7262072_+|prolipoprotein-diacylglyceryl-transferase	gnl|CDD|376615	pfam01790, LGT, Prolipoprotein diacylglyceryl transferase.	6.1552e-26
NZ_CP036274.1|WP_145096279.1|7250841_7251210_+|response-regulator	gnl|CDD|381097	cd17542, REC_CheY, phosphoacceptor receiver (REC) domain of chemotaxis protein CheY. The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	6.40747e-44
NZ_CP036274.1|WP_145096304.1|7259841_7261332_+|radical-SAM-protein	gnl|CDD|224875	COG1964, COG1964, Predicted Fe-S oxidoreductases [General function prediction only].	8.28576e-78
NZ_CP036274.1|WP_145096273.1|7246692_7249593_+|hypothetical-protein	gnl|CDD|223716	COG0643, CheA, Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms].	0
NZ_CP036274.1|WP_145101010.1|7243013_7243490_+|chemotaxis-protein-CheW	gnl|CDD|238374	cd00732, CheW, CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together with CheA and the methyl-accepting chemotaxis proteins (MCPs), which are involved in response modulation.	6.60612e-51
NZ_CP036274.1|WP_145096285.1|7253210_7255112_-|sodium:proton-exchanger	gnl|CDD|182633	PRK10669, PRK10669, putative cation:proton antiport protein; Provisional.	8.40062e-165
NZ_CP036274.1|WP_145096270.1|7245827_7246667_+|methyltransferase-domain-containing-protein	gnl|CDD|224271	COG1352, CheR, Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms].	2.30553e-76

Protein sequences

>NZ_CP036274.1|WP_145096279.1|7250841_7251210_+|response-regulator
MTKRLLVTDDAIIIREMIKDTASRAGWEIVGEACNGQQAFEKFRELKPDAMTLDLVMPEFDGLHALRSILGEDPSAKIVVVSALDQKTILKEAFKLGAADFVVKPFDHGQLVATLNRVTGVC
>NZ_CP036274.1|WP_145096276.1|7250297_7250789_+|chemotaxis-protein-CheD
MPCATLAPSTCHQAGMGKIVLASGPDSITTVLGSCVGVAIYHPRTHHAMLAHVVLPASSGRASLPGKFADTAIPDMLQQLASLGICDNSLIVKLAGGSNMFGLPAGPMQVGESNLVAVEAALTKAKLRVASRHVGGNKGRRVTFDCQTGVYRIEVVGAEVVIL
>NZ_CP036274.1|WP_145101017.1|7249709_7250234_+|chemotaxis-protein
MCRWTNGQITLTLDEIAEMPLEEVSTNLDLGDDLLTMVALTLQGELGGTMLLTFDEENGRSLAASLLNRPRATTPEWNELERSALNETGNILGCAYMNALTRFLDAELIPSPPYFLQDFGASVLQQALMTQALTCDTATICRTTFRREDQALDWNVLFLPTQGLRDRLMNCTTA
>NZ_CP036274.1|WP_145096273.1|7246692_7249593_+|hypothetical-protein
MSAETTAADEWLQGMMSDFLDEAGSLLISLNEDLLTLEAWTANNASQRSPLDPELMNNMFRSAHSLKGLSAMLGLTNINQLTHRIENVFDASRKGQLDLTSSIVETIFQSIDALTAMIAKLQDDGSDQYDASAVMLGIEQVLESGGCARQQTSQADAEKALAACEQGLQLDAALDSPARVEPAPKDLHPEVAALEQIVDETDIPPKYLAIFIDETDLALESLAEVLLCAERSAQLRTVEELLVTAHRIKGSAASLGLNRTAKLAHWMEDALQTAGERKLVLPPSLIDALLHCVDALRLYVTGLKQSVPDCSQFASSAAELLVASNEAFANCPPIQVEPPAIVTAWQPQAIAVQLGELETGTQFSCELHFEANLPLVGLKANLAYEKAVRLGQILHCDPTAESLEEIEQLESLRLIVQSEASRDEIAAALNVNGVRSVDVRVLSAQSKKCEDPAMAVAQQSTHLPTTTNSAKPTQSLPAVEDARPSAAEAKSKATDEGGKPSETLRVDIDRLDQLMNLAGQLVISKARFSQIGTAMRESLPAKQLTQVWSETAAFMQQLADDDAHGASAQHAAATMSSIRSHARRLQSDIEKITAEFARVTKLHARVSELFEAVHQLDRVAASIQKSVMDTRMVPVGPLFNRFKRVVRDITRLNGKDIRLVIRGESTELDKRMIDELGDPLIHMVRNSADHGIESPEARVATGKAAQGTITLDAFHRGNSIVIQVSDDGKGLDRDRILRKGVERGLVDAETAERMTAHQVFQLIWEPGFSTAEKVTEISGRGMGMDIVRSKIEGLSGTVEVESNPGQGTVFTIKLPLTLAIMPSLMAEIDGDVIALPIESIAEIVGLKDDSLGTVHGLRTATIRGRVVSVVELKELLTWNSHSSRTQCKPAGDHTIVVIRYENREIGLLVDTVLGEEDVVIKSLADNYRNVEGVAGASILGDGRVSLILDVGALVNLASRPVVKSGT
>NZ_CP036274.1|WP_145096270.1|7245827_7246667_+|methyltransferase-domain-containing-protein
MTTATETLISPELMMRYGKLIYDVTGIRISPQKQALLANRVRRRLKATNIADFEGYLRHLQKLKPANAEWDLFLQEITTHETYLFRDESHWTWFQDQYLAAISQEAIAGKRPRSLRIWSAACSTGDEAYSAAVCVAACVKQMSPWTIKIIGTDIGIGAVEQARQATFSQRAMKLVPPSLRTRYFTAAEEPEFSKAKPELSALVQFRQHNLLDPLREQPFDLIFLKNVLIYFDEASKQRVVANVLKLLAPGGYLVAGAAEGISDHLKNLKRIHAWLYRNE
>NZ_CP036274.1|WP_145101013.1|7243694_7245719_+|PAS-domain-containing-protein
MAENSPINILFANKDLVITYANPASIRTLKTLEKYLPIRAEELIGKSVDIFHKVPSHQRRILSSDRNLPHRAIIAIGDQKADLLVSPTYDDKGEYLGPMVTWEVVTEKLMLEDKSRDSNEQLAAVGKVTAKVEFNMDGTIVTANENFLGAVGYSLNEIVGKHHRIFCSKEYANSTAYSQFWDKLNRGEFEVGEFMRVNKRGEEIWISATYYPINDVNGKPCKVVKFATDITAARKAAIAANEKSAIVENAPINIMLANNQGIITYINPASMKALKKIEHLLPIKADQIVGSTYDIFHKMPAHQRRLLADPKNLPHLTQIKLGGEILSLQANAIFDAKGNYSGPMVTWEIITERIAAEEREKENQLRERRTQQELSEKVTEVLAVVNAAAAGDLTREISFSGDDSMGQLASGVRKMMTDLRNIISQVVEGAAQFAEGARVIAETAQSQAQGAQTQSASVEEMSASIEQLTRSIETVKNNAASANTLACETSRMAEEGGQAVQKSVEAMGRIKSSSEQISEIIQVIGEIASQTNLLALNAAIEAARAGVHGLGFAVVADEVRKLAERSSEAAKEISKLIKESTQRVADGATLSEQTGQALSKIIQGVDSTAKKINEIATATVEQAQNATEVAGAVQQISTVTEQAAASCEEMASSSEELGAQASTLRELVRKFKTE
>NZ_CP036274.1|WP_145101010.1|7243013_7243490_+|chemotaxis-protein-CheW
MTPVVGSSTQSQTTSSQLVSFRLADEEYGIEITKVQEIILLGEVTRIPQSPVFIKGLINLRSTVIPIVDLRLRFGLPEQAKTDEARIMVVNVRGKTIGLIVDAVSEVLRILAEQIAPPPPTIAGLGRDYLTGLVKLEKRLLILLDVDKLLDEAALAAA
>NZ_CP036274.1|WP_145096267.1|7241415_7242414_-|hypothetical-protein
MTNNSNRATTVSSPRAGAGISRRQLLASTCALGGAMVAGCTPSGPAQGQLDAVWGNPGTGEGKLNHPRAICIDADNLLYIVDKTPRIQVFTPDGKLVRTWQTPEFQFGKPCGLSFDLEGNLLVADTHYYRILTYTKEGKLLAEKTIGGERGFTPGKFHFVTDCQQDAEGNYFIAEYGEFDRVQRFTRDRQFVSQWGGHGSDIGQFLRPQKMEFDRQGLLWITDACNHRLQVFDVSGPEPKLAKSWGEYGSGPGQLSYPYDLHLDEPAGHIYLCEFGNHRIQKFTLDGQYLGHWGRNGRQPGELDQPWGLTRDSYGRLYVIDTYNHRVQRFWL
>NZ_CP036274.1|WP_145096264.1|7241158_7241407_-|hypothetical-protein
MEFIDYSWLIIIRQVSKDEMSRDLGHMQPAWEKLQLQQIDGDEIWEFDCDAHLPHPLAGCSGFLLKRGGQVVNHLVISRSFI
>NZ_CP036274.1|WP_145096261.1|7240118_7241060_-|hypothetical-protein
MKFLTSLVCLVATACLALPLSAGELTVEKKDDGVVVKADGKPFATYVFKSGTKPIVWPIIGPTGQEMTRSWPLKDGVEGEKKDHIHHRSFWFTHGNVNGVDFWGEVAKVQGLINHKELIKAEGGSTAVISTRNEWVGPDGKVICQDEPTLTFGANDNARWIDFATKVTAVADEVTFGDTKEGAFGVRVSETMKVDANKGGKIVTSEGLSDKAAWGMPAKWVDYHGPVGTETLGIAIFDHPSSFRHPTTWHVRTYGLFAPNPFGLHDFPNGKDRNGAHTMKKGETFALKYRVYFHKGDEKEGKVAEAYAKFAAE
>NZ_CP036274.1|WP_145096282.1|7251799_7252942_-|redoxin-family-protein
MLRTLAITLLSLPLLSLVAAAADAPKKELLVGDPAPPLALKEFVKGEPVKEFAKGKVYVLEFWATWCGPCIKSIPHVTELQARHKEAVIIGVDVMEDADDDVKEFVKQMGKKMEYRVAIDAKDPKSEEAGIMARTWLEASYQEGIPASFIVNGDGKVAWIGHPMELDEPLAKIIAGKWDLAAATKTFKDEVESTKASKALDEALEKAMESGKPQQIVAVLDTAFAKTPALEKEHGALKFNALLAQDDQKEKALAYGKKLIDEVAKDDPNALYSIANALLTDDEDQPIDKVDAASGKLALQATSQLVKLLDGIEGMPAANKSVALESVALAHFASGNFKEAVAAQEQAIKMAKGSEREKDASLAATLKKYQAASQPGATKK
>NZ_CP036274.1|WP_145096285.1|7253210_7255112_-|sodium:proton-exchanger
MHSLDTLSTFATSLLAASPAAHSDHLELIITLTSGLAAALFMGYITHRVGLSPIVGYLLAGIAVGPYTPGVEANVELAQQMAEIGVILLMFGVGLHFHFKELLAVRRVAVPGAVGQSLIATGLGVVVAYFFGWTVSSGLVFGMAISVASTVVLLRVLSDNNDLHTPTGHIAVGWLVVEDLFTVLVLVLMPVLFGSANSSLADIGLAILIAVIKIGLLVAFVMFVGGKAIPWFLARIAQTRSRELFTLTVLVVALGIAVGAAKVFDVSMALGAFLAGMVVGRSDFSSRAASEALPMRDAFAVLFFVSVGMLFDPNQLITSPGLIAATLGIVLLGKPLAALAIVILLRYPLRIGLSVAVALAQIGEFSFILAGVGMSLNVFTSQQYNALIAAAIVSISINPILYRLTDYLEERAKKSPRLWKLINGNSHVESTQQAPDDEHPEKHDHGQAVVIGYGPVGRTLCRLLQENGIEPTVIEMNLTTVRQLREDGMRAVYGDSAHKETQLEAGTSQADVFILSASGLRNSQEVIRLARECNPKIRVFARASYLREIPSLTRAGADVVFTGEGEVAMSMTEFILRQMGAGPEQIDRERDRIRNELFGSAAVLEILLPPTAKPMPEQPETSADEALPADPTT
>NZ_CP036274.1|WP_145096288.1|7255121_7255496_-|hypothetical-protein
MAVSAGRDANSGDRSASPAAVNTEKNRPGLRSQLPVLDAFAEKSVFPVPGDAGAAPPLLSTKALGAREGKESAGTPVSGPNATPWDRIDFGNTSVCRRSREYFRNTAIFGPIYRLSPPKARLVL
>NZ_CP036274.1|WP_145096291.1|7255822_7257919_+|glycogen-debranching-protein-GlgX
MLMRHVHPKLQFTYMMPYGAILHENGVQFVVYSRSAQAMRLLLYDGVDDREPTEIIDFERDTDRWGDIWSIFVPGLSAGQLYHFQADGPFDPSQGHRFNGRARLIDPYAKALAGNFQLSEDGIVRPPKCVVVDDFFDWEGDRHLRRPISETIIYETHVAGFTKDPSSQVKKPGTYAGLIEKIPYLKSLGITAVELMPIHEFPIGGIYGQKQERENYWGYDSMAFFSPHRGYAHNTEPGGQVAEFKQMVKALHAAGMEVILDVVFNHTAEGNEMGPTLSFKGLENKTYYMLANGGSHYMNYSGCGNTVNGNHPVVREMIFHCLRHWVHNYHIDGFRFDLASILSRDRNGHLVPNPPLVEAISEDPLLADTKIIAEAWDAAGAYQVGSFGDLRWAEWNGRYRDDVRRFWRGDKGVLGSFVTRLAGSSDLYGHSGRAPHASINFITSHDGFTMNDMVSYRDKHNEANGEGNRDGDNNNYSDNYGVEGPTTRPEIENLRVRQIKNFLSTLLMSQGVPMLVMGDECRRTQRGNNNAYCQDNNISWFDWSKVNQHKDLLRFSQGLIKFRRVQPTVRRETFLSGQAPVDGALPDVSWYSALGTAVDWHGEDNTLICLLKAEDLVEKHPEARDVLILINATSEPREFILPPVAKGTKWRLFIDTAAATPYDIYPDFDGPPPPRSRRLTLSYRSTCVFVAEDPPRLP
>NZ_CP036274.1|WP_145096294.1|7258149_7258824_+|hypothetical-protein
MLTLWHSLLAAPILGDPNVQPNIASSDRHWFIVSRWQEFSGEARANMLRVLAIIVFYAIQLIQRPGTAHGTSLEFHRQVTFIAVAWSLIALAVLLCLQRRIFPAILKYVVTTFDVALLTILAMLAGGPSSPVTNVYYLILALAALRASVGMTWYTTIACLLGYLTLVAEADPVWFDAEHATPIVNQLMMLACLAITGIVIGQVVRQQRSLAVAYAERQAVGVAK
>NZ_CP036274.1|WP_145096298.1|7258820_7259288_+|hypothetical-protein
MSNALPVHQAPHCPECGAEVQGFGDCWLCHRRNANLQGVQPPPIAYQSPAAPQNNSVYYTLKGLSIAAFLMVALIGLGLLNSDTSFGILFWIVVLPALVSMAVVACQFNPAQRAAPGAMNVIAKVVMAIGLTLGMIVVCVTVAVGALFIICTSMM
>NZ_CP036274.1|WP_145096301.1|7259324_7259819_+|hypothetical-protein
MNQPQFSTKPLLQCPECGAEIDGVGTCWLCNAHVTEPRLLSAAKFASEGTSPFAPTANRRQQQWLIAIAAFVMATLVGIGTYVYEPILGVLYLIVVTPAMVAVAVSILTYRESPHSSNSLLARVVAVLATFLATVVIILAIGAILIVVAIIALVVLCFRLIGGN
>NZ_CP036274.1|WP_145096304.1|7259841_7261332_+|radical-SAM-protein
MPAHRDYTFLGTTQSLCPECLGLVPTKIITRGKRVYFRKTCPTHGLREDFVCSDVAYYDRHEFSVPAKLPEVVGVEPDKGCPFDCGLCTEHEQHTCVGLVEITGNCNLTCPMCYASSAPGGKHLSFAQVTAAIDRLVQVEGRAEVLQLSGGEPTVHPEFERIVEYALAQPIDYVQINTNGIRLASDPELVKRLAEHRDRLEIFLQFDGLNDSVYEQLRGEPLLALKLRAVEILGEHDLHITLAATLQAGVNDDQWGPIVEFALAHPWITGLNLQPATYSGRYYLPAEIERRITFPQVIEELSEQTGGLLQPNDFMPLPCAHPNCHSLAMIFRSESAGNIPVNRFFDVKQNYDLLANGISFTRAKSRELAMQYLSRQSCCAGGCAPATEERTSGLPMFGSSPEPQLDADMLKNLSPAALEFFGRVLNEQMGARDLFRITITSFLDAYNFDVRRVMKCCTHHVLPSGHVIPFCAYNVLYRPGHVALPPLTIQQLVRTP
>NZ_CP036274.1|WP_145096307.1|7261331_7262072_+|prolipoprotein-diacylglyceryl-transferase
MPPNLAYSAMMLLSLLVGAILLRRWQSGLSLLWWQKLGIGFGAFCGAFLGAKLPFALYDWANTNVANPWLGDGKTIMFGVVGGYLGVEVAKWSLEIRQRTGDSYAVPVAVAVALGRLACFIGGCCFGTPTTLPWGVVFTAQGPLPRHPTQLYEFAFHITAAALLWYFHSRGWFRYQLIKLYILSYLVFRFVTEFIRPEPEFYGLSAYQWIALALFPIFIGLWVQTDWQVRKENVLSNVTEKPPHGA
>NZ_CP036274.1|WP_145096310.1|7262175_7264455_+|DUF1549-domain-containing-protein
MDALLSAMNNCCRQLPIAAIVMLKIAAALVGMASPAQATEGQVNVAPSFNRDVMAVLSRSGCNMGACHGNLNGKGGLKLSLRGEDPALDHRTLVRELEQRRVNLHDPAVSLLLQKPAGQVVHQGGLRFSSHSHEYQVIHDWIAAGAPGPKSKEAKLVKLEVEPSETVVVAPQEKLQLEVTAVFADGKRRDVRNLAVYELTDNLAEVNSDGLVQRLSLGETTILVRYLNLQTPVRIAFLPSSPAITWQAPLPENRIDEHVFARLKTLQLAPSQPCDDATYLRRAYLDLLGILPTPAEGQVFLADQSPDKREQLIDRLLTRPEFAEQWALKWSDLLRNEEKVLDIKGVDLFYEWLRKSFAHGLPLSDLVQELVTADGGTYENPPANYYRAMRDPFVRGETTARLFLGVRLQCARCHNHPYDTWTQDDYYNWAGVFARIDYEIPDNKRKDKFDKNEFIGQQIVKIKSEGEVKNARTGKDARPQLLGAKKPVDTKSERLDALGEWLTSADNKRFAENQANLVWYHLLGRGLVEPIDDFRATNPAVHPQLLDQLASDLIAADYDLRSLIRQIMSSQIYQLASSPNLSNGQDVRNFSRTVPQRLSAEKLLDAWCQVLDMPIEYAGYPLGTRAGQIRGVERVRSREKPPTTADRFLKTFGKPDRLLACECERSGETTLKQAFVLLGDAGLDALLSQDENRLAKLAASDRSNEQVVAELYFVALLRQPTSAELEAAMELLTQHEKRLNGLQDLAWALLNSKEFVFRH

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP036274_1	1.1|26029|26|NZ_CP036274|CRISPRCasFinder	26029-26054	26	NZ_CP036274.1	26077-26102	0	1.0
NZ_CP036274_4	4.1|5088601|36|NZ_CP036274|CRT	5088601-5088636	36	NZ_CP036274.1	4746136-4746171	0	1.0

1. spacer 1.1|26029|26|NZ_CP036274|CRISPRCasFinder matches to position: 26077-26102, mismatch: 0, identity: 1.0

tgatgcttcgcactgctacgcttcgg	CRISPR spacer
tgatgcttcgcactgctacgcttcgg	Protospacer
**************************

2. spacer 4.1|5088601|36|NZ_CP036274|CRT matches to position: 4746136-4746171, mismatch: 0, identity: 1.0

cggtggcagtggcccgacgaccctcatcggcggcat	CRISPR spacer
cggtggcagtggcccgacgaccctcatcggcggcat	Protospacer
************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP036274_3	3.1|3532596|28|NZ_CP036274|CRISPRCasFinder	3532596-3532623	28	CP054921	Streptomyces sp. NA03103 plasmid unnamed1, complete sequence	92273-92300	7	0.75
NZ_CP036274_5	5.1|7251435|32|NZ_CP036274|CRISPRCasFinder	7251435-7251466	32	NZ_CP017104	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872c, complete sequence	410750-410781	10	0.688
NZ_CP036274_5	5.1|7251435|32|NZ_CP036274|CRISPRCasFinder	7251435-7251466	32	NZ_CP051182	Thalassobius gelatinovorus strain NEB572 plasmid pAge77, complete sequence	6561-6592	11	0.656

1. spacer 3.1|3532596|28|NZ_CP036274|CRISPRCasFinder matches to CP054921 (Streptomyces sp. NA03103 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.75

tagttcggtcactccgtgaccgagaagc	CRISPR spacer
ccaggcggtcactccgtgttcgagaagc	Protospacer
. .  ************* .********

2. spacer 5.1|7251435|32|NZ_CP036274|CRISPRCasFinder matches to NZ_CP017104 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872c, complete sequence) position: , mismatch: 10, identity: 0.688

tgaataagcttcgcgcagtggctgcaacgcca	CRISPR spacer
cagttccgcctcgcgcggtggctgcaacgcac	Protospacer
... *  **.******.*************  

3. spacer 5.1|7251435|32|NZ_CP036274|CRISPRCasFinder matches to NZ_CP051182 (Thalassobius gelatinovorus strain NEB572 plasmid pAge77, complete sequence) position: , mismatch: 11, identity: 0.656

tgaataagcttcgcgcagtggctgcaacgcca	CRISPR spacer
cagcgcctcttcgcgcattggctgcaccgccg	Protospacer
...     ********* ******** ****.

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	8219694 : 8277082	37	Microcystis_virus(33.33%)	transposase	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP036274|8219694:8277082|DBSCAN-SWA
TTCATAACACACCTCCCGTCGTCAGCGCGCAGGTCAGTTCACGGTAAGACAGGAGATTGGGAGGAGGGATCGAGTGCGACTGCAGATGCGGATGATTGTCCAGCCGAAACCACCGCGTCGGCTCTTCCAGTCCCTGCTGCACGAGCAGCCGAATCGCATCGACGGCCAGAACGTCGATCTCCAGTGCCCGCTCAATCGCCGCAGTTAATGCAGCCAGCGAGATAGTCTCCAGCAGCCGCAAGGTTTTGATGAACTCCCGGCGGCCGTGTGCGCCGCCATCTGCTTCCAGACGCCGCCGGAGGAGATCGAAACAGTCCGGCAAGCCCCAGTTTTCCAGGGGTTTCGCGAAGTCCAAGCCCCCTGGCTTCCGCTCCAAGAGTGCCAGGTAATGCAGCGGGTTGTAATGGACCTGCTCCTTCGACCAGTCGCGTGGATGCTGGGCAACCAACTTGTCGTTAACGACCAGCCGAACTTCCTCCAGGCCGCCAATTGCGGTCACTTTCTGATGAGCATACTGCGTCGGCACCGAGTAATCGTTGCCGTCGAAGCGAACCAAGGAAAGAGAGTTGGCCTGGGCCGGTTCGACTCGCCGCGCTTCAAAGCCCGACTTCGGCAGCGGCAACAACGCAGCCTGCTCCTCTGCCAACAACGTGGCTTTGTTCGCCGGTTGTCCGCGTAACTGGCGTTCCAGATCTTCACAGCACTGCCGCTCGAGTTCGGCATTCAGCACTTCCAGGCTGCCGGTCCGTGGTACCGGCACCAGGAAGTTCCGCCGCGCGAAACCGATGAGGTTCTCCGTATGCCCCTTCTCCATCGGCCGTCGCACCAGGCAGAAGTGATGCTCAAACAGATAATGACTCTGCAGCCGTAGGAACTCACGCGTCGGCGTGTCACCCCGTTTCCCCACGAACCGGGCCACAGCAATCCGGCTGTTGTCGTAGCTGATCCGGCGGGGCACGCCGCCGAAGAACTCAAAGGCCCGCTGATGGCCCGCTTGAAACGTCTCGGTGCATTCGCGAGGAAAGACCTGCACGAAGAACGCGTCGCTGTACGGCAACGACATGACGCAGTACGCGACTTTCGTCGGCATGCCTTGCAGCACCACCTCCGCTTCGCCGAAGTCGAACTGGGCTTCGCCCGGTTGATGCGACAAGGGTAAGAACACCTCCGCCGTGGTCGTTCGCCACTCCCGCACGACCTCGCCGACCACCGTGATCCCGCCGGTGTAGCCATGCTCGGCACGCAGGCGGTCGAAGATCCGTTTAGTGGTGTGGCGCTGCTTGCGGGGCGCCGTTTTGTCCTGCTCCAGGATCTCGTGGATGATCGGCAGGAACGGATCGAGTTTGGGCCGCTCCCGGGGCAGACGTTGTCGATAACCGGGCGGCTCAGGGTGCTGCAGGATCTTTTCGAGGGTCTGCCAGTGAAGGGAAAATTCCCTGCAAACCGCTCGTTTGGATTTCTTCTCGGTCAGGACAAGACGACGGATTTCGGTCCAGTTATGCATATCTCGCAGCATGGGCTACGCTCGCGGATCGTAAGGCTTGAGACGCTGGGAAGCCTCAAATCTGCCTTACGGATTCTCACGAGCAGGGCTAGCGCTGCACTTTTCGACCGACCATCGGCTCCGCCGCGCGCTGCACTATTCGACCGTCGTTTACACAATTTGCCCGGGCCGAAGCCTCGTTTGCTCAGGCCTTCAAGCTCAATCCCAAGTTGGCCACTGTTGAGGGGCACCTCGCCTTGGCCGAGACGCAGTTGGCGCTGGATGGTTTCGCCGAGGCTGAGACCTCGGCTGCTGCAGCGTTTCGCCTCGATGGCAATTCCGCCAAAGCTCAAGCCATCATGGGGCTCGCAAAGCTAGGGCAAATGCGGAACAAAATTGCATTAGGGCATCTCGACGTTAACGACCCAATATCCAAAGCTGTGCGCAGCGATCCCCAATTGACGGGGTGGATTCTTAACGAAATGAACCGCATTAAGCCGGGCTATAGAATCGCTGGACTGGGCAACAGTGAGCAAATGGGCCGAATCGAAGATCAAGTCGCCGCGGCAAACGCCATCGGTAAGGAAGCTGTGGCACTCGCCCAAAAAGGTGACTTCAAAGCCGCCGCCGACACCATGCTCCGCTGCGCCGATGCGTATCCTAACGTCACACCTGGCATCCCCTGCATGATTCGCCAACAGGCCGCGCAACTCCGTTTTCAATCGGGCGACAATCAGACCGCGCTTGCCGACGCCGACCGCACGATCCAACTCTTCCCCGATTTGCCGCCGGGGTACGTCGCGCGGTACATCGCGCTGAAGTTACTCAACCGTGACGCCGAGGCCGTGGCGGCCAAGCAAAAGCTAGTGGAAATGAAAGCCCCGGAAGCCGAACGACTCGAAACCGCCCTGCAAGCCATTCAAGCCATGCAAAGCAAGGCCAAGCCGTAGCGATAATTGCCCCCGCCCTGTGCCAAATTAAATGCACACTCAATGAAACTGGTGCATCGTAGTGGGATGCTGACTTTTGTCGGCAGCTAGTTGGAGAACTGAGGGGCCAAAAACGCGAATCGCGCGTTGGCACGCACGCCACCGCGACGAAATCACGATCTCCGGCCCGTCGTTGGTCGCGATCGATCTGCCGTCGGGCGAGATAGCTAACGCTCGAATTTCGCCCGCAATCGCGGCAAAACTTGCCAATGGCTTGCCATCTGTAGCATTGACGTATATCAGTAGGCCGTCGAGATGCGCCGTGACTAGCCAGTGGGAATGCCACGTCAGCGCCGAAGACTGCGGGCTTTGAAACACACCCACCATGTCGATTGCTAACCAGCTCAAGGCAGCGCTGATTACCTCCGGTAAGGCATATACCAAACTTGCGAAGGAGGCTGGCGTTTCGTATGTAAGACTACTGCGATATATAAGCGGTAGATGTCGACTAGGCCCCCAGCCATAGTTCGGACTGCTGGCGGGCCTTTTTCGCGCACAGGTAGAATGGCGGAATGAAACTCACACTGCGCGAACTATTCCTCGTAACTGTAGTCGTTGCTCTTGGGCTCGGATGGTGGCTAGACAATCGGCAAAGAGCTGCTCAAGTCGAATCACTCACAGCGTATCACCGCGCGCTGAAGGAAGTTGCAATGGTCGCACATCAGCAGCGGCCCATCGACAAATCCGATCAGCACCATCTTCGCCTTGTACTAGAGCAGCTTTCGGTTACGAGCAATTGGCAACATCCGGCAGATAAGCGGTAATCCACATAATGCCCACCAACCGCGCTCCCCTCATCGTCGCTATCGTCTTGCTGCTGCTTCTGCCGTCCGTCGGATAGTAACCGGTTCCGGCATCTGTTTTGACACGCCGACCAATTTGAGCCCCCTGAATCTTCGAAGTTACAAACCGCTTACAACATCGCAGCTCGGCTGGCGGTATCGTGATAGGCAAATTTGCCGAATCAGGAGCTGCGCGATGTTTCGATTTCTGCTGACTGTCGTTGTCCTCTGGCTGGCAATTCCGCTCGCTGCCTTTGCGCAAACAGGCGATGCCGCTCCCAAGAAGCCAGAGGCGCGAATGCCGATCGGCAGGACGCATGGAATGTCAGGTGGAACGTTGCAATCGAATCACGAAAAGAGTGATGGCACGCGCGTGCTGCATGGGCTGCAGGTGGTGTACGGGCCGCGGTTGCAGATCAAAGAGTACAGCGTATTCAATCTGGGACGCTGCGAGCAGCTTGTGCAGATCCATCCCAACGGCAATTCTTTCCGCATGCAATGGCGGGAGCACAATGGTGATGGCCACGAAGCGCTCTATGCCTCAGGGGCGGACACCATGATCGCCGAGAAAGTGATTGTCGACGGCGGGAAGGATATCGGCCCGATCAAGGTTCCGGAGCGAATCTGTCTTGGGTGGGTGCGAGCGGGGAAATGCTATTCAGGAACGTTCCTAATGCGCGAAGTGCAAGGCTTCCAGTTCGTGCTCCGACTGCACGAATACAAGGAAGGCAAACTCGTCAACAGCAAGCCCTTTCCTTTCGAGCGATTCGGGATCCCCGTGGCAGAAGCCACCGAAGAAAAGTGGCGCTGGTCCTTTCCCGAGTGGCCGCAAGCGGGGAAAGAATAGCACCACCAGGCAGTGGCGAGCCACGATTCCGCAGCCGAAGAATACTCTGCTCGCGCGAGTTAGCAAAGCTTCTTCACGTTGACGAAGCGCATGGCTGAGAGGTTGGACGCTTTGATCTCAAGCAGTGGATAGCAGCCATTGCCTGGGAGGGTGGGAATGAACCGCCGGATAACTTCGCACCGGCAGGTCTGAAAGCGACGGTGCCTTTCAGCAACTCCCTTAGATTCAGCACCTGGACGCACGCTGTTTTCTATCGAGTAGGGGGGCAAGAGGCAGCTCTCCACTTCACACACTAAAAATTCCGCACTTGGACAGAGGCGCTAGGCTGAGTTTTGAGGTGCCATCTTCAGAATAATGGCTTCGAGATCCTCGCGCGTCTTGATATTGCTTGCAATCTTTGTGTCGGGAGGAACGTCGTCGTTCCACGGCTTCATGTCCATTACATCGCCGAAGTAAAGCGTTCCGCTAGCCCAGCGCAGCCAGGTCGTATCGCTGATGAACCCTGCTAGCCCGGCATGGTGTCGCACTTGTCGAAGCCAATGTCGATGAGCGCTTCTGTTGTGATTGAGGTTGCCATATGTTCAGCCTGAAGCGGAACGTGTTCCTATCTACCGCTCTTGTTCGGATTTTGGCTTTTTCGGTGGCAAGGCAGGATTGAAGATCTTCGCCTCAGCTCCACACTCACACTTGAAAATAAAATCTGTGCCGCGGCCATAGGGCTCGATGCGAATCAGTGTCATGTGGTCAAAGCCGCAGACGGGGCATCTTCGTTCTTCGTGTGAATCCATGTGGCAATCTTACGAATTCACTTCGCCGCGGCTAGACGGAATCGTACAGCGCGGCCAAGCGGCGGCCAAATAGACAAAATATCCGCTACAACCCGAAAATATAGTATTACGTTTCGCCGATTGACATGCCCGTTCTGCAGGCAACAGTTTATCTGTGGTGGCAATCAGGCGGGATTGGCGCCATTACGCCTGATTGTGACGACGCTGGCAAGTGAGCATCGCAATCAGGCTTTTTCGTGCGCATAGAAAAGCCCAGTCAATAGGGACCGGGCATAGCGGGCGATTTCTGGGCAGTCGTCGCTTCGCTAGGGAATGACATCGGTTGTAACCGGAATAAGCTGCATGAGAAGCTTCTGCCTGGCGCACACTCGGCACGCAACTTGACGCCCGCTAACCGTGTGGAAGAATTGTTCGTGGTGCATTCGAGCAGGTTGCTACCACTACGCCTGATTGTGACGACGCTTGCAGGTGAGCGTTACAGTCAGGCTTTTTCGTGCGCGCAGGTAGGCATTTCCCCATTGCTAAGAGCGCGGGTGTCATCCGATGTCACCTGCAGGACTCAGCGACTGCCCAGAAGCCGAACTCCTGGCCCCGCAACTCTGGCGGGGCATTTTCGTGCGCGGGTAGAATGGGGCGATGGATCAGAACCCCTACGAGTCACCTAGCTCGCCATCAAAAGCTCATGCGGCACCAGCGCCGCGAAAGGCTGCTTGGAGAAGTGGTGCGATTATTGGTGCCGTCGTTGGGCTAATCACCGGCATCCTTTTTTCCCCGACTGACTATGAAGCGGCGTTTGTAGTGGCACTTATGTCTACGGTGATTGGGGCGGTAGTTGGCGGCTTCATAACGCGCAACACCCCAAGTTTAAACAGATGACCAACCGCGCACCTCTCATCGTCGCCATCGTCTTGCTGGTGCTTCCGCCATTGCTGTACGTGGGGAGTTATCTGGCGCTGGTGAAGCCCCAGGGCGACATCGTCTGGAGAAAGTCTCGGCCTTTTTACTGCCACTACCGAGTTGGCAGCGAGAGAGTCGTCCCCAATCTTTTCTGGCCGCTGGAACAACTTGACCGAAAACTGCGGCCAACCGAGTGGATCGGCCCAGCAGGCAAGGATGACTAGAGCCGGTTGCAAAACCGCGTCTCGCTAGCTGAACCGTTGTGTGTTGGTGATCGTAAGATTCACGAAAGGAGTTCGTCAATGTGCTCAAGGTCTCGCGAATTGGCGGGATCCAGGATGGAACCGACGGAGTTGGGGTATCGTCCGCAGCTGAATGATGAGCAATGGGCGTTGATTGCCGATTTTTTTGTCGAGCCGGATCCGGACCCACGTGGTGGTCGACCGCGGGCCGCTGCTCGGCATTGCCTCGAAGGCATTTTGTGGGTCTTGAAGAGCGGCTCACGCTGGAAAGATCTGCCGTCTTGCTTCCCGTCATACGCGACGTGCTGGCGACGCTTTGCCGCCTGGTCGGTCGACGGAATCTGGGAAGCGGCCTGGCGACGACTGGTGCTCGCGCTCGATCAACGCGGCGACATTGAGTGGGAAGAAGGCTTTGCCGATGGCACGTTTGCCTCGGCAAAAAAGGGGGCGATCTTGTCGGCCCCACCAAACGCGGCAAGGGAACCAAGCTCATGTTGCTGGTCGATGGCAACGGCTTGCCACTGGGAGTCGACGTCAACAGTGCCAGTCCTGCGGAAGTCGGCCTGATCGAGCCGCTGCTCGAAGAAGCCGTCACCGACTACGTTCCTGATCGCCTGATTTATGATCGCGCAGCCGACAGCGATCCTTTGCGCGAACACCTGGCAGATCGCGGCGTGGAATTGATCTGCCCCCATCGCCGTGGCCGAGTGCGGCCACCAACTCAAGACGGCCGCGCACTGCGTCGCTATCGCCGCCGCTGGATCATCGAACGCACCATCAGTTGGCTTCATTCCTTTCGCCGACTGGTCACACGCTACGAGTACTACTCGTTCCTCTTCCATAGCTTCGCCAAGCTGGCCTGTATGATGATAGTCCTCAGACGGTTTTGAAACCGCTTCTAGGCAACACCTTGCCAATCGACCGAAAGGCGAGGCCGGGAGCGTGGAGTATCCCGCGAGACCTACTGCAGTCGGCAATCACGATTGAGTGAAGTCCACTTCACCTCAAGCCGGCGGGATCGTCGGAAAGAGCGGCGGACTAGGTACCGTGCTCACTGCCCTTCTTAGGAGTATCGGCGTCACGGAGATGCCCGGCTGCAACTGCGGCGCACGTGCCGACCGGATGGATCGCTGGGGAGTCGAAGGTTGCTGGGGGAATATCGAAACGATTTATAGCTGGATGGAAGAGAGCCAGGCCGCGTTCGGTTGGCTGGAGAAAGCCAGGGCAGCAGCAGCGGCGTTTTCAACGGGGCTCGCCTTCGGGCTAGATCCTGCCCGACCGCTTACGAGTTTGGTCGATCTAGCGATTGAGTAGGCCCAGAAAAATAAGGACGTTGCGTAAGGTCCACGAGGTGCAACCGAATCAGAGGGCAAAGGAAGCTAGAAGCTGAACGAAAGACGCGAAGATGCCAATTCGGATCCATTCCGTTGCAGTGAGAGCTTCATGATCGTCGCGTTGGTTCATAAGTTCGGTACACCACGCCCCAGATCATGCAACTATTGATCAAACCCAGTGCGGTAGTACAATCGAGGGGATTGTGGCGTTCGCAAGCTGACGAGACTTTGAATGCATTCGACTTCGTTTACACTTCTTGAGCGGGTCAAAGTCGCGCGAAACGATGCGGACTGGGATCGATTCGTCAATCTCTACACGCCAATGCTCTTTGCTTGGGCGAAGCGGTTCGGGTTGGGAGATGCGGACGCATGCGATCTAGCGCAAGACGTCTTACTAATACTACTTAAAGAACTGCCAAACTTCGAACGAGGTCGCAAGTTTTCCTTCCGAAGTTGGCTTAGAACGATCGCGACTAACAAATGCCGCGAGCACTTGCGACGCAAGAAGCCGCAAGCGCTAGATCCGATGTCGGCGCTCCAGCTTTCTGATTTCGACGCCGAACCCTTCTGGGAACATGAGTACAGGCAACTCTTAGTCGCGCGCGCGCTCACTGTGATGAAGGCAGAGTTTGAAGCAACGACTTGGCAGGCGTGTTGGGAGCACGTTGTGTCAGGGCGTAAAGCCGCCGACATAGGGGCGGAGTTACGTCTCAGCGAAGGTGCCGTCTATGCCGCGAAATGTAGGGTCATGAAACGACTGCGTGAGGAACTCGAAGGACTACTTGAGTAACTAGCTACCACAGCATTCGGACAAGCACGAAATGTCACCCGAAAGTAATGACATGAATCCTGAGTCATGTCTGACAGACGAACTACTTAAGCGTCTTTATGAAGGCTTGCTGAGTGAAGCCGAGCTTAATGTGGTCGTGCCTCACCTCGAGTCGTGTGCTATTTGCGAACGACGTTTAGCTAACGTTTCTGTGGGCGGTGGAGAGGTTGCCCAATTCGTTCGACAAGATGCTGAGGGCCAATTACCTGAGGTCGTCGAAGATCTGATGCGAGCCCTGCGCAGTCGTCGATCGCCGTCGTTGAAACAGGATTTGCCCGCGCACTTCAACTGCCCCCACTGCCATAACCCGATTGAACTTGTTGCGGACGAGGATCTCAACGAAGTGGTCTGTCCCTCATGTGGAAGCTCATTGCAGCTTGACCATTCGGAAACAAAGACTTGGAATCCTACTCAGCTCCCGATGCTCGGTCGTTTCCAACTCATAGAACGCGTTGGTCAAGGCGCTTTCGGCACGGTGTATCGGGCCTACGACAAGGAACTGGACAGAACTGTCGCTGTCAAAGTACCACGCAGCGGCCGGCTCGCGACCCCGGAGGACGAAGATCGTTTTGTTCGCGAGGCCCGTAGTGCTGCAAAGCTACGTCACCCGGGAATCGTTGCCGTTTATTCCGTCGAACGCAGCGATCGCTTCCCCTACCTCGTTACCGAATTCGTGCAAGGAGTAACTCTTGCGGATGCGTTGACCGGGCGAAGATTCACGCATAGAGAGGCGGCCCGCCTGATCGTTCAAATTGCTCGATCGCTCGAACATGCTCACGATCAAGGTATAATCCATCGCGACCTAAAGCCCTCGAATATCATGCTCGGGGATGATAGCGGTCCCCGCGTCATGGACTTTGGTCTGGCAAAGCGCAGCGCCGACGAAATTACCATCACGTTAGAGGGCCAAGTACTCGGCACTCCAGCTTACATGAGCCCAGAGCAAGCCGTGGGTAGCGGACATCGTGCCGATAATCGTTCAGACGTCTACTCGCTAGGCGTTATCTTGTATGAGTTGCTTACCGGCGAACTCCCATTCCGTGGGAATGTTCGTATGCTACTCCACCAAGTTGTGCATGATGAAGCGCCGTCCCCCCGAAAGCTTGACCACCGCATTCCGCGGGATCTGGAAACGATCTCCCTTAAGTGCCTTTCGAAAGATCCCGCGAAGCGCGTTGCCAGTTGCGGCGAGTTGGCTGCGGAACTTGAACGCTGGCTGCGAGGGGAGCCAATTCTCGCACGACCCATCGGACGACTTTCCCGCTTCGTTAGCTGGTCACGGCGTCACCCCGATATAGCAGGTCTGCTCGCAACCGTCCTCACCGTGTTACTTATCGGAATTAGCGTTTCGACATTCTTTTGGATCAGATCTGCGCAGAATGCAGTTGTCGCCGAGGCAAACGCGCTGCAGGCAAAAGCGAACGAATTAAAATCGAACCTAAACGCAAAAATCGCGGACGAGCATCGGCATGCTGCTGAAACAAACGCGAAGCGCGCTAGCGCAAATGCCGAGAGAGCAGAAGAGCAGTCGCGGTTTGCGAAGCAAAAGGAAGAAGACGCGCGTTGGAGTGCCTACGTATCGGCGATGAATTTGGGATTTCAGGCTTGGCAAGATGGATATGTGGGAAGGGCGCAGCAACTACTTGAGGAGCAAATACCGCAGCCAGGACAACGTGACTTGCGTAGCCTGGAGTGGTTACTGTTATGGCAGCAATGCCATGAGCAGTCATTTGCCCTTCGCGGGCATCAGAAACGTGTCAACTGCGTAGCGTATTCTCCGAGTGGTGAAACTCTCGCCTCTGCAAGCGACGATGGGAGTGTAATCTTATGGAATACCTCGGATCGCACCATTCGGAATCGTATTCACCAGCCAAATGCCAAAGTGAAGGCACTTTCCTTCTCGCCAAACGGGAAATGGTTTGCCACAGCAGCAGACAATGGCAACGTGATCATTTGGAATGCGACCTCACTTAATAAAGAACGAGAGTTCCTCACTGGTCTAACTACGCTTGATGTGGTGAATTCGATACCTTTGACTTTGGTAATTTCGGATGACGGCAAACTTCTAGTTGTGGGAGGCGAAGCATCAATTCGCGTGTGGGAGACAAGATCTTGGTCTGAGGTTTTTCGCAGGAACATTGGGCATTCCGCTATCGCCATTTCTCCAGACAGTGAAGTGCTTGCCATTAGTGATCACAGCGGTCAAACCAGACTGTTGGCAATCAGCGATGGCCGCGAACTTGCAAGTCATGGAATATACACCTTCGCACTTGGATTTAGCCGGGACGGAGCGTTTCTCCATTCGGCCGTCACGAATGGAAGCGGCCTTTACAAGTACGATCGCAAACTTGGGCAAATCGCGCAGTCTGTATCCAAGGAAGCAGCGCCAACTAAAGACTTAGCAATTTCTAAATCTGGTGAAATTGGAATCTTAGTAGGAGGTGACGGATCGGCGTCAGGAACGATTGATGTGTGGGATCTGAAAACGTATTCTTGGATCAGGCGACTATCCGGGCATGATGGATCGGTGTGTAGTGTTGCCTTTGCGCCCGATGACCGCAAATTTGCCACAGGTGGTGCTGATGGAACGGTGCGGGTATGGGATAACGAATCATTGCTTCAAAATGGACGTTCGCAGGGACATCGCGAATACGTCCTCGCTTGCTGTTTCTCGCCGGACGGTTCTCTCGTGGCCACCGGCGGCGTTGATAAGACAGTTCGAGTGTGGGACTCGCGGACCGGCGAGCTCTTGCAGCTACTTCCACAACCCGAACGCGTTTTCGGAATTGCGCATTCGCCAACCGAAAAACTGCTCGCGATCGCAAGTGCCTCGCAAGCGGGTGACGGACTAAGAATTTGTTCAACGAGCGACTATCAGCAAGAGTCCGTTGCAGTAAATGGACTTGAACCGCTAAGTGTTTCGTTTTCGCCTGATGGAGAGCGCATCGCATGTGGAATGAGGTCCGGGGAGGTTTTGCTGCTCGATTCGACTGATCGCACTGTTCTGAACTCGTGCAAATATCACCTAGGGCCCGTTTATTCAGTGGCGTTTTCAGCCGACGGCACATTGTTAGCAACGGGAACTGGCGACAATCATTGCGCTGTAATAACATCCGACACGCTCGAACTGCGGTACTTCTTACGGGGTCATACCAATGCAATTCGTCAAGTTGCGTTTTCACGCGACATGCAACTTCTCTGTACGGCATCCTTAGATGGATCAGTTAAAGTCTGGGATCTGCATTCCGGTACGCTTAAGGCGACTCTGGCAAAATCACCTTTGTCCGCATTTTCTGATTCCTATGCAGTAGCGTTCACCCCCGACGGAAAGTCAATTGTCGGAGCATATTCCAATGATCAGTATGATGGTGAGCTGCGGTTGTTTCAGGTCTCGGATTTAACTCAACATGGCAAATTTGCTGTACCTTTGGCTCTCGTTTCCAGCATGGCGTTGAGCTGCGACGGAAAGCAGGCACTACTTGGGCTAAATGATGGTCGCGTATCAATTATTCGCCTCGATGATCCCACTGCTACTAAGACTCTAGGTGTCCGCTCCGATTGCTACGGAAGTGACTTCTCACCGGACGGGAGTAAGTTTGCCGTCGGCGGCTACCAGCATGTGTCTGTGTTTGACACATCTACTCGTAAGCAGCTGTTCACGAAGAGGGTAGGAACCCAAAACATTACTGGTGTTCGATTCGTGGAGAACGGCCGGCGGCTATTGACAAGTGAAAGTGAGCCGGCTCACGGGCCTCGCAGTCCAGGCGAGCTGTGTGTTTGGGATGCAGCCACCGGCGCTAAAGTGACCACCTGCTTGATTGACTCACAGAGCGGCCTCATAAGCTTAGCGCCCGATGAAAGGGAGCTGGCACTTGTCGGCGTTGCTTCGCAGACCGGAGCGCCGAACATCATATTTCTACCCGGGATTAGTACTGTTCAAAAGAATGCTCGAATTGTGCTTCCAAAAGGCGTTGGTGGTGCAGGCTTCGAAAACATCATGTTTTCACCCGACGGAAAGCTGCTCTTGCTAGCAGAGGGTTCCTATTTCGATAGTGAGCCGGGCACGGTGATCATTGTGGACCGGAAGACGAGTAGCGTTATTGGAAGCCTGCGTGGGCATGCAACTTCAGTGACAAGTATTGCGTTTTTAGACAACGGGTCCACCGTCGTCACCGGCGGAACAGATCGCACTCTCCGCGTCTGGAGCATGAAAACTGGTCAGTTGCTTCGAACTGTTAATACTCGTGAGGCTGTCCTGGCAATTGCGACGTCACCTAACAGCTCACGTTTAATAACATCGCATTCCGACAGAGTCTGCCGTATCTGGGAAACGGTCACGTGGAATGAGATCTGCTCGTTTCGAGCACCATCGGGCCTGTACGGTTCGATCAATGTATCGCCCGATGAGACCTCGTTGCTGGTCACAGGTTCTAACCGAACCTCGATTCGACCAGACTATGAGGTGTTAAGAATTGCCAAGCCGGCAGATGTAGAGACCTATCGCGTTAGGGAAGTGGAGTTTCACGAAGAAGTTCGACGGGCATCAGTGCAGCGGCGTGAGGACGCAGAGTCACTGCTTACGAGGTTGAAGACGGCACACGAAGATGGGCTGATCGGCGAATCTAGTCTATTCTTGGGACATCGTCTGTTTTCGGTCGATTCCGATGTTCTTGATGTCTCGGAGCATGAGGCTCGGGCGCTTTTTACCTCGGCATTCGAGGGAGCCCTAGCATGGGATAAATTGCCTATTCAATTGAGCAAGATTGAGCCTATTAAATTGCGAAAGAGTCGCGAGCAGGGTGCGGCAAATGCGAAGCGAAAAAAAGAGGGGCTCGAGTATATGGCGGGGCTCTTGCAAGACGCGAAGCAGAATGATTCCCAGGCCACCCAAAACAGCGCCCTTTCGTCGTTGGAACGAGTGCTAATATTCGATCCGGCCAACGTGGAGGCACAGCAAATGACGGCGAAGATCCGAGCCAGCGCGCCGGCTGCGTCAATTACGAATACCCTTGGGATGACGTTGATCAAGTTAGAGTCCGGTCGGTTTTGGATGGGAAGTCTAAATAACGAAGAAGGGCGACGACCTGATGAGGTAATCCACCCCGTTCGGTTTACAAAATCGTTGTTCTTGGCCGCGCACGAGGTGACGCGAGGTCAGTTTGCGGAGTTCATTGAAAAGTCAGGGTATGTGACAGAAGCGGAGTCGGCGGCATCCGACGCAACGCGTGACGTTCTGACTTGGCGCAGTCCGGGGTTCGAACAGGATGATCGCCATCCAGTTGTGTCTGTTAGTTGGCATGATGCAACGGCATTTTGCGAATGGTTATCAAAAGCAGAGAATAAGAAGTATCGCCTTCCTAGCGAGGCTGAATGGGAGTATGCGTGCCGCGCTTACTCGACAACCCCATTCCATTGGGGCGATCGTCTTGACCAGGGAGAAGGCTGGGGAAATCTTGCGGGTCGGGACGATGATGATCTGACGAAGCCAAGCGCTCGGGTTCCCTGGAGCGATAAGAGGGTGTTTACAGCGCCCGTGGGAACCTTCAAAGCGAACGCTTGGGGATTCTATGACCTTGTGGGCAATGTGAGTGAGTGGTGTCGAGATGACTATCAGTCATATCCTGTATTGCTGGTAACCGATCCGAAAAGTGACCGCTTCGGATCACTTCCTGTCGTGCGTGGCAGTTCATTCTCGAGCGAGCCGACGACATCCCGTAGTGCGTTTCGGCACCGCCTTCCTGCAAAAAGAGTTTCAACTAGCACTGGATTTCGCGTTGTTTTGGAAAGTGACGACGAAAAGTAACGGCGTGTTTTGTCGTTGAGGGTGTACCACGTTGCCAAGCAAGACGCGGCAACTTAAGTCGCCTTGCTGTCGCCAGCGATAGCTCGGCTACGAGCCAGTTCATCGGTCCATTCTACCGCTCGCTTCGCGGGTTCGGCGAAGGACCTCACGGTTAGCGGACTCGACTTTGGTGCTGCTGCCGCAACTGAAACACTTGGGTGGCTCCCGATACCTGGCGATGTCAATTTCGCTTTCAGCGAGAATTCTTTCGTTCCGGTGTAAGGTTTTCGCCCGGCGCGCATTTTATGGTTGTCTACCGTGAACTTGAGACAGTCAGTCAACCTAGGAATCACTTCAATGCCCCGTCATAAACACCGTAGCAGTAAGACGTTCCGTCGCCTCGGCAATGGTGTGGAATTGCTTGAGCGTCGCGAAGTCATGGCGTCGGCGATAAGCGCGGCGCTTACCCAGAGCGTATTAGTCATTGAAGGGACACCGGGAAATGACTCGATTCGCGTCCGCCAGATGAACGGTCAAATCAGCGTAGAAGGAGTTGCCGGATCGTGGTCCGCCGGACAGGTGACGGCAATTCGCGTTGCGGCCCTCGATGGCAACGATCTGGTCGACTTGTCATCGGGCCTCAGCGGTCAGCAGAAACTGAATGTTCCCGCCTATGTCGATGGCGGCTTGGGCGACGACAGCGTGGTAGGAACCAATGCCAAGGATGAATTGGTCGGAGGAGGCGGCAATGATTGGCTGCTTGGTGGTCTGGGAAGCGACATTCTTCGCGGCGGTGCTGGAACCGATCGTCTGTTCGGCCAAAACGCCGATGACACGCTCCTCGAAGGGGAGATGAGTGCTCAAGTCATTTCCACCGGCATCAGCGCGGACGGCAAGATTTATGTTCTGCGCGATGACGGCGTTGTTGAGCGAGTCGGGTTTGGCGCGATTGGCACTGGCATCAAGAGCCTCGGAGTTGCGCCGGACGGCGTGGTTTATGGCCTAATGCAAAATCAGATCGTTTACCGCTATGCAATCGGGACGAATTCCTGGAGCAGCATTTCTGGCGCGGAAGTCACCTCGTTGAGCGTAGCAGCCAATGGCGCCGTTTATTGCTTGACGAGCAGCAAGATTGTGTATCGCTACACCGGCATGAACAATCGCTGGGACGCCATCTCGGGTGCCGAGGTGACTTCACTGCAGGTTGCTGCGGATAACAACGTTTACTGCTTGACTACGGGCAAGATCGTTTACCGCTATTCGGGCACAGGCAACAGTTGGACTGCGATCACCGGCGCAGAAGTCACTTCGTTCAGTATTGCCGCGAACGGCACCGTCTACTGTCTCACGGCTGGTAAGGTTGTCTATCGCTACTCCGGCAGCGGGAACGCTTGGAGTGCGATTTCAGGTGCAGAGGTCATCTCACTCAGCACGACGCCCGACGGAGGCGTCTTTTGCCTGACTCAGGGAAAATTGGTCTATCGCTACAACGGCGCCGGCAATAGCTGGACGCCCATCTCCGGTGCGGAAGTCATTACCTTGACGACCACGGCCGACGGCAGCTTGTATTGCCTCACGACTGGCAAGATTGTCTACCGTTACACCGGCAACAGTAATATTTGGAATGCGATTTCTGGTGCCGAAGTCACCTCGCTAGGCGTATCGCCGGATGGCGGGCTCTATTGCCTAACCGTGAGCAAAGTGGCTTATCGCTACACGGGAATCTCCAACGCCTGGAATAGTTTGCCCTTGGCCACTACCGATGGTGGGAGACTCACCATTCGTGGGAGCGAAGGCAATGACACCATCACCGTCTCTCCACTGTCGGCGGGTCGTATTTTGGTTTCCGGAATCGCTGGCAGTCTGTCCGGCGAGTGGAGCACGGCTGGAATTACCAGCATTCAAATCGAAGGGCTTGGCGGCGATGACACGATCGTTAACCAAGGCGGAACCGTGCCGGTTGTAGCTCATGGTGGCGTGGGAAACGACCGCTTAGCGGGCTCCCACGCACTGGACGCGCTCTACGGTGATGAGGGAAGCGACTTGATCGAGGGGAGCAGCGGCGTCGATGGAATTTATGTCAGCAACAATGTGCTGTACGTGATTGGTACACCTGGTGACGACACACTCGAGTTTCACCGCAACAATGGCCGCGTAATCATCCGTGGTCACCGGCCCGACCTAGGGCTGCATACGGATCTAACACGCAACTGGCCGACGCCGACCCGTGTGGAGGTTTTGGGATTGAATGGCAATGACACGATCACGAATGTTTCGGTGCTTTCGCCGGTCATCATCAAAGGAGGCGACGGCAACGATTTTCTCCGCGGCCTGAACCCGACGGATGGTCTGTATGGCGAAGAGGGGAACGATACGCTCGACGGCAGTGCAGCCTTCGACATACTGGCTTCGAACGACGGCGTCCTATTCGCTGCCGGCACTCCCGGCAACGACATCCTCACTGTTGCTCAGAACGATGGCTATATCCTGCTCCGCGGGGCAGGGAAGGAAGTGACTCGTAAATGGGCTTATAAGCCATTGCCGGGAGTGACCGAGGTGTATCGCGTGGAAGTGAGTGGCCTCGGAGGCAATGACACGATCACCAGCATCGCAACGGAATTTGGAATTACTGCTCGCGGTGGCGCGGGAAATGACCGGCTTACGGGTGGAGATGGTGATGATCGACTGGCGGGCGGCGTCGGAAACGACCTATTGATTGGCCGCCTCGGTAATGACACTTATGTCTTCGAGGACGAAGCGACACCTTTCGAAGTTGACACTATCGTCGAACTTGTTGGCATTGCAAACGGCATAGACACGCTCGAGTTTAGTGACGTGTCGCGCGATCTGTTCGTCTCTCTGCGGGTGAACGGTACGATTTCGACCGAATCTCTGCGGATCATAAATGGTATTGGAGGAGCATTTGAGCGGGTCATTGGCGGTTCCGGGAATGATGTACTCCACGGGAGTGAACAGCCCGACTTTCTATACGGAGGCGACGGAAATGACACGATTTATGGATACGATAGTGATGACATCTTATTGGGTGGATTCGGAAGCGATTGTTTATATGGTGGGCAGCACAATGATGTTATAGACGGAGGCTTTGGCTACGACATCATCTGCGATACTGAAGGGGCAAACTTGTTCTTCGCTGATTTAGTCATCCAGGCCGCTCAAATCCGCAATGGCACCGCGATCGTCACTACCTCTGCCGACACCGTTATTACAGGAAGCTCAGACACGGCAAAGAATGTTATTGTGGCACGTTCCGAATCGGCGGTGGGAACGAGCTTCGAAGGGGGCTCTCCCAAGGTCGGTCCCAGCGATGGTGCAATTGTCGTAACAAAGACATTGAAATATGTTACGGCCGGCACGGTCATCGGTGGTATCATTGGCGGAGTCATCGGTACAATCGCTTGGGGGCCTGGCCCTGGTACGGCGGCTGGTGTCCTCGCCGGTGCCAAATGGGGTGCATTTACGGGGGCGGCGATAGGTATTGGAGAGGGAATCTGTGATTTGATCGCCAGCATATTTTAACTCATGATTTGCATTAAAATCATTACGTTACTCCCCAGGCACTCGTTTCAACTTGCTTGAGGCTAACTTACTGGCGGCCACCAGACGGCAGCATAATAGGCAACCGCTACTGGAATTTACTTCACTGCATTCCGGCTTCGATGTGCAATCTTAAGCGTTTAAACTCGCCCATCATCCCTGGTGCAGGTTCTCCTTGGCCGTGAGCAGGATGAGGTCGCGGATCTGCTCCGGTGTGTTCGGCCGGCCCCGCTTCCGCTTCTTCGGTTTCTGCTTCTTCTCGGCACGGATCCAGCCCAGGATGGTGGACGGCGCCACGATCGTCGTCAGCTGCCTCAGGACCTTGCCGCCGAGCTTCTGGGCAAACTTGACCAAGCGATTTCGTTCCTTGAGGGTGACCGTGATGCGTTTCGGCAACTTTGACCGGAGAATCTGGTTCTCGACCTTCAGATATTTGATCTGGCGGGCCAGTTCTTTCTGCGTGGAGCCGGCGATCACGAGCAGCAGGGACCGAAAGACGTTGGTCATCGAATTATACGCATCCCAGGTTGAAATAGCGCGCATCCTATTGCGCCAGCGCAGTCTACCCAGCATGATAGGGCAGCCCATTCAGTGTGGAGGTTGCCTTGGACGTGCATTTGCATTTGTCGCTCGAAGAGTTGGTTCGGCGGGAGCGAGTCGAGAAGGATGCGGCGCAGTCGAAGCGATTGCGGATTGTGATTCTGGCGATCGGTGGGTGGACGGCTCCGGCGATTGCGATGTCGGTGGGTCTGTCGCGGCGAGTTTGTCAGCGGTGGGTTTATCGCTTCAATGAATTCGGGCTCGCGGGTTTGGATGATCGTCGCGGAGCAGAACCCAAGCCGACGCTCACACCCGAGCAGCAAGTGCAAGTTTGCGAGCGGCTCGAAGCTGGGGCGACGCTCGCGGATGAGGTGTGTTCGCTGCGCGGCGTCGATGTGCAGCGGATTCTCGCCGAAGAGTTTGGCGTGCTCCGTTCGCTGGCCGCGGTTTATCATTTGTTGCATCGGCTGGGCTATTCCTATTTGACTCCGCGGCCTCGTCATCGGCGGTCGAATCCCGCAGCGCAAGAGCAATTTAAGCGGGAACTGCCGGCGCGTTTGCAAGCCCTGCGCACCGAGCATGTCGGCAAGAGCGTGCGGGTTTACTTTCAAGATGAGTCGCGTTTTGGCCAACATGGAACGACCACAAATGTGTGAGCTCGTCGCGGCTCACGACCGACGGCCGTGCGGCAGACCGAATACAAATATCTGTGGGTGCTCGGTGCCGTTTGTCCGGAGACGGGCCACTCCGATGGTCTGCTCAGTCCGCACCTGAACACGAAGATCGTCAACATCTTCTTGCAGCAGTTCTCGCAAACGCTGACCGCCAATGAACACGCCGCGCTGATCTGGGATGGTGCCGGCTTTCACACCAGCAGCGAGTTGAACGTGCCCGCAAACGTGACCATCATTCAACTGCCGGCCTACAGCCCGGAACTCAATCCGATCGAAAATCTCTGGCACTATTTGAAGAGCCACTACTGGTCAAATCGGGCCTACGCAGACTACGCCGACCTGGAAACCTCGGCGATCAAAGCCTGGCAACTCGCCGTCCTCGACCCGGATCTGATGAAAACCGTGTGCGCCGCACCCTACGCCGACGGCGCTACTTTGAAGTAGGATGCGTATTACAATGGATTTGACGCAGCGAAATGATGGGAGTGCTTTCTTTTTTGCACCCCGCCGGGACCGTCGGCCATTTGAAACGTATCGCGCGTTAGGTCGATGTGCTGGAGCGACGTTGCTCAATCGCATCCGAGAGCGCAGAGAATGCGCGCCGCTGTTAACCCGATGCCTAAAAAGTTCGAAGAGGGTTGCGACCGTTTCGGACACCGATCGGGACTCGGAATCAGCAATTACCGCTCTCACAACCACTTATGAAAATCGAAAAAGAGAGTACTGTCACGTAGAGGGTTGTGCACAGGGAGGTGGTTAACAGCCCATCTTCACAGACGGCTTTCGAATCATTCTCTCGGCTGTTAACCCGAGGCCAAAACTAGAGACTGGGGTATCCGGCCGAACTCTCCTCATTACCGCTTAACACAAAACCGCGTCCCTATCTGAGACGACAAACAGATATCGCGTTTAGTAGGAGAGTCCCGACCAGGGAGGTCGTGACGTTGGACCATGCGCAGAAGCTGCACGATCTGACGGGGACCGTGAACAGCACGCGGTTCTTCCGCTGGACGGCCGGTGCGCGATGCTGCCGAGGTCACGCGTATTTACTCGACGATTTGCCAGCTGTGCCCGTTACTGAAAAACGACGTCTGCGGAATGTGTGGCTGCAGATGCACTGGCGTGGTCAGCATCACGAACAAGATCGCAATGGCCACCGAGCATTGTCCGCTTGATTCACCGAAGTGGTGAACTTGTTCACGGAGAGATGCGACCGGATCGTCTCGCCGCGATCACTTCACCTACGGCCGCACTGTCCTCGAACCGCTTGGCTACGCCGGGTCTGCCACGGGATCTTCGCCATCGAGTCGAACGTGCAAGACTGGTTTCCGCGTGCATATGATCGGGGGAATGAACCAAGTTGCATCCTCGGCCTGTGTTACCCCCGACTTGAGGAGTACAATGCAGCGTTGGCTAATGAGTAAGCCGACGTAGTGGACGACCCCTGGGTGTTCCGCCACGTCGGCTTTTTTATCGTCGGTACCCAACACAACAGGGAGAATACCGGTGATAGACACAAACATCTTGTTGGTTGACGACGACTCGGACACCTGCGATTCGATGTCGGACGTGTTCTTAGATCTCGGCTACACGGTGGATACGGCCCACGATGGTGCAAGTGCCTTGGAATTGTCCGGGGGCCATCATTACCGTTTGGCGCTGCTTGACTACAACATGCCCGACATGGACGGCCTGGAACTCTGCCGACGCTTGAAGAACATGCAGCCAAACATCGTGGTTGCACTGATAACCGGCTTCACTTCCATCACCACCACGGGAGAGGCAGCCGAGGCGGGGATTAGGTGTTCGTTCCTAAAGCCAATCAATTTCTCATTGCTGATGCCGCTTGTGGAAAAAATTGTCGGAAACTTTGTTTTTCGGCGTTTGGGATCAGATGTCCCAACGTAACCTTGCGGCAAAAATGGCGAACTGAAGTCAGTAACCAATCTGGCTATTGCCCAAGGCGGTGGTGCTTTGTGAAGTCATCCGCAGCTGCCGAGGATGAACCTGCGAATTATACTCTGGCCCTCTTCTTAATTAGTCGCGCAGGCGATCAATCTGCCCGCTTTGGTTGACAGTTCTTTAAGTCAGCTTTGCACTTCCTAGCAATTCCCGAAGCTTTGCGAGCATATCGCAACGAATTTGGCATTCTTAGCTTGCAATCGATCACTTAGCCATTTAACGCCGCGGGCATCCGAAGTCTCCTCTAAAGTTTGGCAGATCTGAGGTTTTCGAGAGGCTGGATGACGCAGGGCGAGTAAGATTCAGACCATATACACGGCTCACTGCATGGGAGAGCTAATTATGACAATTGACCGAATCTGTTTACGAAGCATCGCTCTGTTTATCGCAGGTTTTCTCCCGCCACCCGGCTTGGCTGCCGATTGGCCGCAGTTCATGCGAAACAGTGAGCATACGGGGGACGCGGCAGAGGAAGCGTTGCAACTTCCTCTCGGCCTCGCGACCTGTGTGCGACTGGACGACGCGATTACCACTTCGCCGGCCGTCGTGAATGGTACGGTCTTTGTCGTCGATCAAATGGGAACCGCATATGCCATTGATCCAATTGAAAGCAAAATCCTGTGGCAATCTTCTCCCGACGGCAATCGTGCGATGGGTGGCAATACGTCATCTGTCTGCGTTGCACGCGGACGAGTTTACTATGGCACCACTGCCGGCCGGCTGCACGTGCTCGACGCCAAAGACGGAAGGCTGATTAAAAGCTTCGACGTTGGCTGGCCGATTCTGGGTGCAGCGGTGTTTGCGAACGATTCCATTTACCTGCAATCGGTCGGGGCGATAGTGCATTGCTTCGACCTCAATGGCACCGAACGCTGGCGCTGGGATCACTACAAGTCGTATCAAGACCCGAAGACCAACAAGCTCGCCTCGGGTTTTCCCGGAAGCTTTCACGATCCGCATTATGCCGGCGGAGAGGTGGCAGTCGCAGGGAACCGCGTCGTCGTGAACATGGGCTGGGATTTGTACTGCCTGAAGGACCAAGGGGAAAAGCCCGAGATGGTTTGGTGCAATCGCGCGCCGCTGGGTAAGGATCCCGGCATTGCGATGGGCCCCGCGATCAACGGTGAGTGGGTCTATGTAGGTCATCCAGGAACGGATCAGTTCGGCGGGTTCATGCGTGTTCGGCTTGCCGACGGCGGTTTTGATCCGAAAGTAGATTTCCGTTCAAGCGGGTATCCCGGTTCCGTGTGGGCGGTGTTCGCTACACCAGCTGTGCGCGAGGGGACTGCGTATGTGCCGACGCATTACATGGGCGTACACGCGTGGAACTTCGACAAGCACCAGGCACTTTGGGCGGCTCGGACGGATAATACGCTCGATCAGTCGAAATTTACATCGTGCATTTCGTCCCCGGCGCTGACTCGCGGGCATTGTGTGTTCGGCACGATCACCGGCGAACTGCACGTCATCGCTGTCGAATCGACTGGAGGTTGGCCGCAGTTCAGGCCGACCCCATTCACGTTCAAAACGCCACTCGGGCGGCCCATTGGCTCGTCGCCAATCGCATGCGGCGGCGCGGTCTATTTCGGCTGCGACGACGGCTATTTATATGGACTGAAAGCAGGCGGCAAGCTCCAATTGCCGCAACCCAGGAATGACCTACACGCGGTCCGCTCGCGCGCCGTTCCGGCGACCGGTAGTTCTTACGGCGCGCCGGTTGCCAGCATGGATCAGGCGAATACCGGCTGCGTTGACGACCCGCGATTGAAACCGCCGCTCCGCTTGCGGTGGGCAACGCGACCCTTCGATCTACGCGTGCAGATGAGCGCGGATGAGGACAGCCTCTATTTCATTTCCGAGGCTGGGACTTTCGCCGCCCTCGAACAAGCCACTGGTCGAATTCGCTGGCGCCAACGACTCAATAGCCCGATCGGCGGCTGGCAGCAATTGTTGCTCGACCGGGGCCAGTTATTCGTTACTCGCAGCACGTCTGCTCTCCGCGCGCGAAAGCCTGAAGAAGGAGGTTCCGCCTTCAACGCTTTCGACGCGAAAACTGGCCAACTCCTCTGGCAAGCCGAGTGGGGTTCACTGCAAGGTACTTGCCGCACTTCGCCGGTAATTGTCGGCGACGTCGTAGCAGGAATCACTTTGGAAGGGAGTCCGCCAAAACCGCGAGCCCGCGCCTTTCACGCGGAAACGGGCGCAGCACTCTGGTCGCTCGACTTGCCCGGCAACGCCAAGCTTATGGCCGGCGGCACCTGCGTGCTCGATGGCAAAATGATCTTTTCTTGCGGCCAGACTTGGGGCGCCGGACTTGGCGCCACAGTCGTGGTCGAGCCCGGGACGGGTAAGGTTCTCTGGGAAACTACCGAACACCATATTCACGGCTACGGCAGACCGGCGGGCCGCGATGGTTTGATCTATCTCGGCGGACAGTCGGGCGCTCCGATGGTATGTCTTTCGGTCTTCGATGGTAGCTTGAAGTGGAAGGTCGATATGGTGAGCTATTCTCACAGCCCGTCGCTCGGCCAAGATTTTTTCGTCACGCGCAGTTATGGCGGGCACGGAATCCTCCGCGAGTTAGCCAGCGGCAAGCCAATCATCCGCAATGGCCGCGAAGCCCTGGGCGGCTGCCCGGACCATTCTTGTTCACCGGTGTTGCTAACGACCGGGCGGATTTCGTATGCAGTCAGCTCCAGCGGCTTGTATGCCCGCAACGTCGATTCGGGCGAAATTATTTGGCAGAGCCTGGGCTTCGCTCCGCGGGCCTGCACCACACCGATCGCCGCCAACGGCCGGCTGTTTTTCAGCCCGAATGTAAACAATTCGATTTATTGCTTTGAACCGCTTGGCGTGCAGCGGGACCAGCCATAGCTCACTCGTCCCTCGCATTAAGTCGATAGTTTCTGTGCGGCTCGAATATGACCGAATCAGAAGCAAGGTATTCTCATGAGCGTGACGCAAATCCGGCGAGACTTTCATCATCACTTCGGATCGAGTCATGGGCGAACTCCCAAGCAAGCAGGCGCCGAATAAACCGCTGCTCGAAATGTTTCAAGTTTGGACTGACGATGACTGGTCACTTTCGATAGATGCCGCCACCATCTTTTCCGAACTCGATGCGGCCGACGACTACCTCAGGGCGAATTTTAATCGAGTGATGGGTTAATCAACTCGCACTTCTGGTTTTTCTTTCTTCACCTGACCTATTCTTCGGGCAGCAACGACGCTGGGAAGGCGGACCAGTTCTTTCTGCGTGGAACCGGCGATCATGAGCAGGAGTGACTGAAAACGTTGACCATCGAATTACACTGGATTTCAGGCAGTGAATGAGGGGAGTGCGTTCTTTTTTGCACCCCGGGGGCACCATCGGCCATCTGAAACGTATATCGCTTTCGGTGGAAGTGCCGGATCGATGTTGCTGAATCGCATCTGAGAGCGCGATGGGATCATGCGACGCTAGAAATTCTCTTGGTGCCACGGTTAACAGCCCATCTTCACAGACGGCTTTCGAATCATTCTCGAAGCTGTTAACCCGAGTTTAAATCTCACGACTGGGGTACCTGGCCGAACTCTCCTCATAACTGCTTAACACAAAACCGCGTCCCAATCTGAGACGAAAAACAGAGAGCGCAGTTAGTAGGAGAGTCCCGACCGGGGAGCTTCTATTTCGGCCCTAACTTGGGCCGACCCAACGGTTAACGCGAAACGCCGGCCAGAGAGTTCTGCCGGCTATTGTCGTTTACGCGTTGCTCTGCAGGGGTTTACGGCGAGTGCCGAACTCTCTCCGGTGTTCCTACCGCGCTCTCTATTTTTGCCCGGCGACCGATTTCTTCGCTACTCTCCCGCGAACTCTCTCCGCTCTCTGTTTTCGCCCGAAACTTGGTTAACAGTCTCGTTTGGTTTGGGGAACTAGTCGGGACGCAGATACTAACTGGAGAGCGCGGTGGCAGCTCCGGAGTGTCGGTCCGACGCACGCCAGATTTAATGATGAAGGTGTGAATGAGCGGCACTTTCAAGGCAAGCCATGCGGCTTTTTTTGGCCCCTGTTTAGCGGGCATGTAGGCTGAGCATTCACATTTCAGGCCAATTTCCGACCGAATCGATGCCCGCCCGGGTGAACCCGCGAACTTCGACGCGATTCTGCTGTTGAAGTTGCACCCCATGCGATATGATCACGCTGGGCGTAGCCAATTGAGGACTCTGGATCTGAGGTGCGCTCCCGCCACACAGAGACGTGGTGTTCAGTAGTCATGAGAACCTAATGGCCCTAGCCACCGAACTTCAAACGCCCGTTATGCGCGGCCTTGCCAAGGCCCCAACGGGCATCCAAGGGTTAGATGAAATCACAGGAGGAGGTCTGCCGCGCGGACGACCGACACTTGTGTGCGGAAGTGCCGGCTGTGGCAAGACGCTGCTAGCGATGGAATTCCTGGTTCGCGGCGCGACCGAATTCGATGAACCCGGCGTGTTCATGTGTTTTGAAGAGACCACTCAGGAACTGACGCAGAATTTGCGTTCGCTGGGCTTTGACTTGGACGAACTTGTCGAGCAAAAAAAGCTGGCGATGGATTTCGTGCGGGTCGAGCGAAATGAAATCGAAGAGACCGGCGAATATGACCTGGAAGGTCTGTTCGTGCGTCTTAATTACGCGATCGATGCGATCGGCGCCAAGCGGGTGGTGCTCGATACCGTGGAAGCGCTTTTCGGCGGTTTGTCCAATGTCGCCGTGCTGCGCGGCGAGCTTCGCCGCTTGTTTCGCTGGCTCAAGGACAAAGGAGTCACTGCTGTCATCACGGGCGAGCGCGGCGACGGGACACTCACTCGACACGGTCTGGAAGAGTATGTATCGGACTGTGTCATTCTTCTCGATCACCGGGTGACGGATCAGATGTCGACGCGGCGGTTGCGGATCATCAAGTATCGTGGCACCACGCATGAAACCAACGAATACCCGTTCCTGATCGACGAGGATGGTATCAGCGTTTTGCCCGTCACGTCGTTGGGATTGCTGCACAAAGCGAGCACCGAACGGATTTCGAGCGGCATTCCTCGGTTGGATGCGATGCTCGGCGGGGAGGGGTTTTACCGAGGCAGCACGGTTTTGATGTCCGGCACCGCGGGGAGCGGCAAGAGCAGCATCGCCGCCCACTTCGCCGCTGCTGCGTGCAAGCGTGAGGAACGCTGCTTGTACTTCGCGTTCGAGGAATCGCCCGGGCAAATCCTACGCAATATGCGGTCGATTGGCATCGACCTGGAGCCTTGGGTGGAAAAGGGGCTGTTGCACTTTCATGCCAGCCGCGCTGCGATCCACGGCCTGGAAATGCACCTGTCAACCATTCACAAATTAGTCCGCGAGTTTAGGCCCCGCGTCGTGATCATGGATCCGGTTGGCAGCCTGACTGCGGTCGGGACGCGTCAGGATGCCAGCGTGATGCTCACCCGCTTGATCGACTTCCTCAAGATGCAGGGAATCACGGCGCTCCTCACGAGTCTGACGAGCGGGGAAGAGGCACTGGAGCAAACCGATGTCAATGTTTCGACGCTCATTGACACCTGGCTGCTGCTCCGTGATCTGGAACTCGATGGCGAGAGGAATCGCGTGATGTATGTCCTCAAATCGCGTGGCATGGCCCACTCCAACCAACTCCGCGAATTCTTGCTGACCGATCAAGGAGTCGAGTTACAAAACGTCTATCTCGGCGCCGAGGGTGTACTCACCGGCTCCGCGCGACAGACTCGCGAAGCCATCGAAAAGGCCGACAGTTTGCTCAGGCATCAAGAAATCGAAGCCAAACAGCGCGAGCGCGTCTTGAAGCGCGAAGCCCTCGCAGCCCGGATCACTGCCTTGCAAAAGGAATTCGAGGCCGAAGAAGAAGTGGCGAAGCGGGACATCGAACAGGAAAATTCTCGCGAGGAAACCCATCGGCAGGATCGCGACCGAATGGGAATCAGCCGCCAAGGCGACAAGGTGCTCAAGGATGCCGAGCCCGCCGCTCGTTCCCACGAGACCCCACGGAGCCGCAAATGAAGACGACCACAAGCCAGGAAGGACCCGCCGGGGTTGGGGAAGAGACGGAAACTTGGGAACTGCGGCTGTACATCGCCGGACAAACTCCGAAGTCCGTGGCCGCCTTTCGCAATCTCAAGAAGCTGTGCGAAGAACATCTGCCGGGCCGATACCAGATCGAGGTCATCGACCTCATGCAGCATCCGCAATTGGCGGCCGGCGATCAGATCGTCGCGATCCCCACGCTAGTGCGCAGGTTGCCTGAACCGCTGCGGCGGATTGTCGGCGACCTGTCGAATACGGAACGTACACTGGTTGGATTACAGCTGCGACTCGCGAAACCGCTCACAACGACTGAGGAGGGCTCCGATGCCCGCTGAGTTGACGCCCAAGGAAATCGATTCGTCTGCGGCCTTCGAAAAGTTAGTGGCTGGACCTCCAGCGGACGCGCGCTATGTCTTACGGTTGTATGTCACGGGCATGACGGCCCGCAGCACGGAAGCGTTTGCCGCGATCAAAGCCATCTGCGAAGAGCGCCTGCAAGGACGATATGAGTTGGAAGTGGTCGATATCTATCAACATCCACAACTGGCCATCGATGAGCAGATTATTGCCGTCCCCACCTTGGTCAAAATGCTGCCGGCGCCACTCCGCCGGATGATCGGCGATCTATCCAACGTGGATCGGGTGCTGTTGGGTCTCGATCTGCGGCGCAAGCCAGAATGAGCGAGATCGCATGGCAGATGTGAAACAGTCGGAACTAGCCGAATTGCAACTTCGGCTCGAAGAAGCTGAAGAGACAATCCGGGCCATTCGCAGCGGTTCGGTCGACGCGTTTGTGGTCGAGGTGCCGAACGGAGCGCGGGTTTACACGCTGGAATCTGCAGACCGTCCTTACCGACTGCTGGTGGAAGAAATGCAGCAGGGGGCGATCACGTTGAGCCTTGATGGCACGATCGCCTACTGCAACCGACGCTTTGCCGATTTGGTGGGTAAACCTCTGGAACGGTTGTTGGGCGTGGCCTTTCATGAATTCATCCCGTTTGCCGCACGAACTTTTTACGAGAGTTTGTTACAGCAGGGGCGCGCTGGTTCCAGCGAGGGCGAAACGCATGTCCAGAAATTCAATGGCACCCTGGTTCCAGTATTTCTCACGATTAACGCCCTGCCGCCGGAGAGCGGCGTTGCCATCGGCCTTTTGGTCACTGACCTCACGTCGCAGCACCATCATGAAAAATTGAACTCGCTCTTAGGCGAACTCAAGGAGTCTGATCGTCGCAAGAATGAGTTCCTGGCGATGCTGGCTCACGAACTCCGTAATCCGTTGGCTCCCATTCGCAATGCCGTTCAACTGCTGCGCCTGACCAAGGGTGGCGATGGGGCGACGATTCATTCGATCGCCGAAATGATGGAGCGCCAGCTGGGCCAGATGGCGCGGCTGATCGACGACTTGCTGGACATCAGCCGCATCAGCCGGGGCACGATTGAACTGCGCCGGGCGCGGATTGAATTGACCTCGGCCGTCCAACATGCGGTCGACGCAGCCCGCACACTGGTTGACGAGAAGGTTCACACGTTGACGCTCACCTTACCGTCGCAGCCAGTCTACTTGAATGCCGACCCAACCCGGTTCGCGCAAGTGGTCGGCAACCTGCTCAGCAATGCCTGCAAGTTTACAGACAAAGGTGGTCAAATTTGGCTGACCGTTGCGGTGGATGAAGTCGGTGATGCGAAATCAGGAGCCCATCCGTCGAGCGAGAGTTCTTTGCTTCCTGCCATGGCGACGATCAGGGTGAGGGACAGCGGCTTGGGGATCGCCGCCGACCAGCTGATTCGAATCTTTGAAATGTTCGTGCAGGTGGATACCTCCCTGGGGCGACCCGTCAGCGGCTTAGGCATCGGCCTAGCGCTGGTAAAGAGTCTGGTGGAAATGCACGGCGGGAGCGCGGAAGTCAACAGTGCTGGTATCGGTCAGGGGAGCGAATTCGTGGTTCGGATTCCGATTCTGGTCGAGCGACTCACGCCTTTACTGCCCCCCGCTGACCAGCCCACGGCCATCAACTCACACCGCATCCTGGTCGTCGATGACAATCGTGACTCCGCTAGAAGTCTCGCGATGTTGTTGAAGTTCTTGGGCAACAAAACGCAAATGGCGTTCGACGGGCTGGAAGCCGTGGAAGTTGCTGCGACGTTCCTGCCGGAGATTGTCTTGCTCGACATTGGCATGCCCAGGCTCAACGGCTACGACGCTTGCCGAAAGATTCGCGACCAGCCGTGGGGGAAATCGATGGTGCTGGTTGCCTTAACCGGTTGGGGCGAGGACGAAGCCCGGCAAAAGTCCAAAGACGCTGGTTTCGACGGCCACATTGTCAAACCGGTGGATCACGCCATACTCGCCAAGCTGCTGGCTGAACTGTTGCCGATCCCAGCTTAATTTTCCCGACCTCAATTCGAGTGATTCTCTAAGACGAACTCGGTTCGGTCACATGGACCGAAGAGGAATGGCCTCGTTCGATCCGGGGTACTGGTCGGGACGCAGATACTAACTGGAGAGCGTGGTCACCATTACTGCAGGTTCCCAGCGCGGTAGGCACCCCACCGACGACATCCAATTTGGCCGAGCTAGCCCGAAGCAGTGGTTGCTGTCGTCCCGCTTGCCGAGCCGCGAATACTGGCCAAGGCACGCTAGATTCAGGCTAAACTCTGGTGCTCTCCTCTCCCTTCGCCAAGGACAATCCGTGTCTGACACTTTTGAATCTCACACGCCTCTGCGGATATTAGTCGTCGAGGACAACAAGGACGCCGCTGACAGCTTGGCAATGCTTCTGCGAATCCAGTGCGCACACTCCGTAGACGTGGCTTACACGGGGCTTCAGGCCTTGCAGATCGCCAACATTCGCCGCCCTGACGTGATCTTGCTCGATCTGGGCCTCCCCATCATGAATGGCTATCAGGTCGCTGAGGCTGTGCGAGCTATGCCGGATGCTGAAGAGATTGTGATCATCGCCATCACTGGGCACAGCCAGCCGGAAGCAGTTGATGCATCGGCCGCCGCCGGAATCGACCTTCACCTAGCCAAACCGGTCGACATTCGGCGCTTGCTCAGCTATTTAAGCGGTCGTGGCCTGAGCTGATCGCAGGATGCGTGTGGTTCGTTGGGTTGAGGTAACCAGAGAACGCCGAGTTGAAATCTCAGTTAATAGCGTGGATGCAGCCATTCAAGTTCTGCCCCATGCGGATGAGCTAACGCCAGAAATTCATCTCTTCGCTCACCGCGATGAAATGTTGTCCGGCCTAGCAAGAACGGACGTGGACCCGACGGCGGAGCTAACGCGGCAATTTCCGGAACGACGGATCTCGATTCATTCGAGATCCAGATGATGTCACGTGCTCGGGACGCATCGGCCATGTTACTGGCAAAGATATTTCGTTCTTGAGGGGATACGTAGCTGAGCACTGCCGAATGAAATACGACAAGTTGTGCGTGGTCGGGGGCAATGTCAATTAGTTGCCTTAGGTCAGTCACAAGATTGCCTTGATGCACCTTGACTTCGCGTCGTCTGCCCAAATCCATCGCCGCCTGAAGCCGCTGTTGTCTCTCGACATGATCAGCGAATACGCACGATGACATCCAGCGAGCATCAGTTTGGTCCCGTAAATTGACCGGCGCAAGATCTAACCCCGCTCGCCATACAACCTGCGGCAGTTTTTCGGGCAACGGAAGCACGCCCTGAGTCTGGCACCGTAGCCTTACGGGTGACTCTGGAATGCCAATCTTTGTGTCACCATAGTCGTAGTAGAACTCGTCTAGAAGCAGACAAAGCCCGGCACTTGCACCGACCTCCAGTAGTGCGAGAGGACCGTCAGGCAATGCTGGCAGTAGTACTGCACAGCGACCAACTTCGTTAGTTTGCGTGCGTCGCAATTTCATTAGCGTCGCTATTTCTACACCTCTCCGCTGCACAAAAACTTCTAACTCTTTAGCCGACTTTGGCATCCACTCCTGCCCGGCAAGGTATTGAATAGCAGCCAGAAAGAGATTGGGCTGAATGACGGGCAAGGGGGAAAGGAATGCAACAAGCTCCTCCTTGGCGGCAACCGCATGGGCCAAGTTGAAGTACAGGTCGGAGTAACCCTGGCATTCATTGTCAGCAAAACTCCGGTAAACGCCGCTCACGTGGTCAAAATCAAACATCCTCGTGTTTCCTCAGTAACCTGCTGACATGGCGAAGCAAGTAGCTGTGTTCACGCTGATCGACAACAATCTGGCCGATCCTGTTGTCGGTAACTTCGCCGGGCAACTTGGCGGTTCGCTGGTGAACGTAAATGGTTTCAACAAGCAGATTTCGTATATTCGCGCCGCCACCGAAACTACCTCAAAATCGCGAAGTCGTTGTTTAAAATTACTTTCGGTCTTCAGGAAGAGAGAGCTTTTGTTCGAAGAGGGTTGGGCACAGGGAGAATCAACGCGATCCAAGAGCTGGTGACGTCCGACGAGTACCGGCATGTGCCAACCGGGACACTGGCTCGGATCGGGTCTACCAAGCCGGGACCGGCATGGGCCAAAGTCCAAAGTGGCGAGAACTCGCGCACAAAAGTCCAGAATGTCGTGAAACACAGCGTAGCGGACATTCTCACTGCTCATTCTGGCCGTAAGTCAGCCCAGTGGTGAAATGGTCGTGGGCGCAGTGCTGACTATCGGCTTGCAGCGAAGGATGTTCTCATCGTGCTCGCAAAACCCGAGAACCTCGAACGATTTCGCAGGCATCACGGCCGCGGAGCCGAACCGATTTAGAACAACGGGCTTGGAGTTCGTAGGGGGGCTCGGCTGGTATCGCAAGCATCGAGCAATTGAAGAAAGCGTGATGCGGCTATGCGAACAGTTGGCTAAGGCGTGCAATTTGAGGGCTAGCGCCGATAGGGTCGTGTGCGATCAGAGCTATTTTCCAGCTCCGTGGTAGGTATCGGAATGACGCGTAGATCAGGACCCTTTTCAGAAATGTGAAGAACGTGTCGGCAGTGCTCGTGACAACTGATGCACGTGGTGAGCGAGTTCATGTAAGTGTACGACGAGCCATCAAGGTTCTTCTCCTCCGCTAGCAGGATTAGCTTCTTGGCGGTGCGTCGTAATTCCGCACGATAATGGGAGTAGACTTGGTCGTCGGTAGCGTGCCAGTTTGTTGCATCGCAGACCTTCGCCATTTCTTCGGCACCCTTGCGGATCAGGTCGAAGTCGCTGGCCATCAAACCTTCCACCACTTTCTGCGAGCTTGCCAACTTCGCTCGCATCAAGCCGGCCAGGGCGTCCTCGCTATGCGTTGGGACAGCGGGCTTGGGTTGCCCCCACGCCAACATCGCTAGGGCAGTTGATATTACGCCGACAATGCCCAGGAGTTTCAACTTCGACATCACCACACCTACCGTCTGTTAGTTCACGGACAAACCCCTTCGTCTTTTCGGCTAATGATAATCGTACAGTTTAGGGATTCTGCCGATTGTGAGGAGCGGATCCCCAAGTAATCATATTCGGCGCTCGAATAGTGCAGCGCGCGGGGGCTGATGGTCGGTCGAAAAGTGTAGTGTTAGCCCTGCTCGGGAGAATCCGTAAGGCAGATTTGAGACTTCCCAGCGTCTCAAGCCTTACGATCTGCACCATGCTGACAACCGTGCTTTGCGCCAGGAAAATTGGGACTTTCCGCACGAGTTCTCGCCACTCGGACGGCTACTCTCCTCGCTCCCGTTGAGTTTCACGCCGACGTGTTTTCGGTGATTATTGAGGGATGACCTCAACCACCCGGACCCAGCGCCGGTATGATCATCGCCTGCGAGAGATAGTCTGCAACAGCAAGAACATCGACGCGGCAGTCGGGTGCGGAGTACCCCGCTCTACAGCTCGTGGCTGGCTCGCGCCGAGGGCGATGTTCGAATCCTGGTGGCGCGTGCTCAAGCATCAGTGGCTGTTCCTGAACAGGCTCGATACCCTGGCAACGGTGCAGAAGCTCGTCGCGTTTTACGTGGACCAGCACAATTCTCATCTCCCACATGCCGCGTTTCATGGCCAGACACCCGACGAGATGTACTTCGGCACCGGCGCAGACATTCCCAAACAGTTGGCGGCTGCGAAAGTCGCGGCTCGGCAAGCGCGTCTGGCGGGCAATCGGGCCGTCCGCTGCCAGAGTTGTAGCGCGCCAGTGGCCATCAGCAACTGACGCCGGTCGAGCGAGGAATCGGGCGAAGTTGGGTGCCGGTGCGCGCGAACGGCATGAAAGGTGCTCCGGCCATCGGACAAGCCGTCGTTCCGAGGAGTGTAGCCGCGATTCTCTTGCCCGGACTCGGACATCTTTTGGCCTCCCGCACCCCAAGTGGCGAGAACTCGCGCAGAAAACTCCCCAATGTTGTGGTTCTCAGCACGGCTAAAATCGCCCCAAGCCGGCCGGGGCGATGAAATTTCAAACTGACGCACTACAGTCGATGGATGTACGCTTGGGCGAGCTTCACTAGGCCGAATCGGCACAGGGCGGCTGCCGCACCACGGGATTGAGTGGGCAGCCTGCGAGCGCTCGTCAAGTAAGTAGTTGCTTGATCACATGCGCCTCTTCCACGCCGGTCAGCTTTTGATCGAGCCCTTGCGACTTCACTGAGAATCGTTGGTGATCGAAGCCGAGGAGGTGCAGGATCGTGGCGTGCCAGTCGCGGAGGTGGACCGGATCTTTCGTGATGTTGTAAGAGAAATCGTCGGTTTCGCCATGCACGACGCCTCCTTTGATGCCACCGCCGGCCATCCAGATGGTGAAGCAACGCGGGTGATGATCGCGGCCGTAGTTGGTTTTCGATAAGCCGCCTTGCGAGTAGATGGTGCGGCCAAACTCGCCGCCCCAGATGATGAGCGTGTCATCGAGCAGGCCGATCCGCTTGAGATCCTGAACGAGGGCATAGCACGGCTGATCGACGTCGCGGCATTGATCGGGCAGGCGCCCCGCGACATTGGCGTGCGTGTCCCAGTTGTTGTGATAGACCTGCACGAACCGCACGCCGCGCTCGACGAGTCGCCGGGCGAGCAGCGCTGTGTTCGCGAAGCTCGCGGGCTTCTTGACGTCGGGGCCGTACAAGTCGAGCGTCTCTTGTGTTTCTTTGGAGAAGTCCGTCAGGTCCGGTACGCTGCTTTGCATCCGATACGCCATTTCGTACTGCCGAATGCGGGTCTGCGTTTCGGGATCGCCGAGTTCATTGAAATTCAACTCGTTCAACGCATTCAAGCCATCGAGCGTCTTGCGCCGGATTGCGCTCGGCACGCCGGGTGGGTTATTGATATAGAGAATGGGATCGCCGGCAGAGCGAAACGACACTCCCGCGTGCTCACCTGGCAGATAGCCGCTTTGCCAGAGCCGCGCCGAGATGGCTTGCACTTGCTCGGTGTTGCTGGGCTTAGCGACCATCACGACGAACGTCGGCAGATTCTCATTCGCCGAACCTAGGCCATAGCTGCTCCACGCGCCGAGGCACGGCCGACCGGTGACTTGGTTGCCGGTTTGAATGTAGGTGATCGCCGGTTCGTGGTTGATCGCCTCTGTGTTCATCGTGCGGATGAAGCAGAGGTCATTAGCCATCTTCGCCTTCCACGGCAGCAACTCGCAAAGCCACGCGCCGCCGGCGCCATGCTGGGCGAACTTGAACTTCGACGGCGAGATCGGAAACCGAGCCTGGCCGCTGGTCATCGTCGTCAGACGCTGCCCTTTGCGGATCGATTCAGGCAGATCCTTGTCGTACCAGTCGTTCATCACCGGCTTGTAATCAAACAAATCCATCTGCGGGGGCCCGCCGACCATGTGCAAATAGATTACATGCTTGGCTTTGCCCGCAAAATGCTGCAGCCCCGCGAGCTTGTTCTCGTTCGGCGCTGCTGCCGCGGATTGGCCAGCGAGCGTCGCGAGCGCGGCCGTGCCGAGCGCGTGGGAGCCGGTCTGGAAGAAATGACGCCGGGTGAGGTTGAGTTGGTATTGGTGGAGAGGGTGCATGAAAATCACCTTGAAAATCGTGGTTATTTGTTCAACACTTCATCCAAATTTAGCAGCTCGTTCACGATCATTGTCCAGGTCGCCAACTCTGCTGGTTTGATGAATGGGTCAGGCTTCGACTCACCGACGGTGATCAATTTGTTGGTATCGTCCGGTGAATTGGAATAATGCTCTCGAATCGTCTTGAGCGAATCCAGCACCACGGGTAGCTCGTTGGCGCGGAGCGAGCGAGCGAGAACATGCTGCGTGACGAAGTTCAACCTAGCAGCGTCATCCGCGCCACCTTCTTTGAGCGTGCGCTGAGCCAGGAATCGCGCCGCTTCCACGAACTGCGGGTCGTTCAGTGTGACGAGGGCCTGCAGCGGCGTGTTGGTGCGTTCGCGGCGAGTGGCGCAGCTCTCGCGGTTGGGGGCGTTGAAGATCTCCATGGAGGCCGGCGGGGCGGAGCGTTTCCAAAAGGTGTACATGCTGCGGCGGTAGAGATTTTCGCCAGTGTCACGCTTGTAGTCGCGAGTGTTGCTGCCGATCATGGCGACCGCCTCCCAGACTCCGTCGGGCTGATAGGGCTTGACACTGGGGCCACCCAGCTTTTGCACCAGAATGCCCGAGGATGACAGGGCATAGTCGCGAATCATTTCGGCATCCATCCGATACCGTGGGCCACGACTCAAGAAGCGATTTTCGCGATCTTTCTCTAGTTTTTCCGGCGTCGTGATGGCTGCCTGACGATAGGTGGCAGACATGAAGACTTGCTTAAAGAACCGCTTCACGTCCCAGTTTCCGTCCCGGAAATCGACGGCCAGCCAATCGAGCAGCGGCTGATTCGCAGGGAGATCGCCGGCAACGCCCAGATCGCCAGAGGTCTTCACGATGCCATTGCCGAATACTTCCTGCCAGAAGCGATTGACCGTGACCCTGGTCGTTAGCGGCTGATCTTCTCGCAATAGCCAGTTGGCTAAGCCGAGTCGATTGCGAGGCACGTCGTCGGCCATCTTGGGCAGGACTTCGGGTGTGTTTGGCTTCACCTGATCCTTACGGCGGTCGTATTCACCGCGCTGCAGAACGAACGCCATCGCGGGCGATTCCTTTTCCTGCATCACATAGGCCTTCGTTCCGCGGGCGATGATGTTCGCTTTCTCCTGCTGCAGCTCATTCAGGTTGGCGGTCGCCTCTTGAAACGTCTTGTCGTTCGTGCCGAGCCACCAGTTGTAGAGTTCGTCGTTTTCGCCCGGCGTTCGCTGATCGGCCGGCTTAGCGAGGAGCGCGGCGAAGCGCGTCGTCTTGGCGAGCGATTCCACTTCCGCCGCCGTGAGCGACTTTTGATAAATCCGCAGATCTTGCACGGTGACACCCGCGAGGATTTCGCCCGTATGTCGTTGTCCGAGCTTGAAGGGCACGCGCGTCTTGGTGGTCGCAGAGAGCTTGTCCGCTTCGACGTTCGTCTTCTGTTCTTTACCGTCGTAATAGAACTTCACGCCGCTGGCCTTCGACGAGCCATCGTAGGTGACGGCGACGTGCGTCCATTGGTTGCCGGGAACCTGGGTCTCGGCGACGACCTTGAGCGCGTTATCGGGCCAGGCGTTAACAATATGCGTGCCGACGCGACGGGCCTGGACCCAGAAATCCCAGCCGCGGTACTTGTTGGCGTTATCCATCCGGGCGGCGATCGCGCCGGCCGAATCGTTGGGGTTGAGCTTGATCCAAGCCGAAGTGGAGAACGGCTGATCGCGCTCGAAATTGGCGACGTCAGCGAGTTCCAAGGCCGCCCCGGTCGTTTGCAACGCCGGTCCCGAGTTGCCCGGCTGCCAGCTGCCCTTCTCCGTCAGCGGGACTTCGCGATCCTTGCCGTCCACCTGAATCTTCGTAGTCCGACCCTGGCCTTCGCTCAGCGCAGCCGAGAGATACAGTTTTTCCGTGGGAATCGTGGCGGCCGCCGAGTTCGTATCGCTGCCCGCGGTCGCTAGCCAGCGGTCGAACTCGCCGCGGGCCTGTTGTTTCCGCGCAGCCTGGGCGGCGGTCGCTCCGGCAATTTCACCGTCGAGCGTGAAATAACGGGCCTGATCTTCCGGCTTCGGCACCTGCATGATCGGGGGCGTATTGGGAATGTTCCCGTCCATCGCCGCTTGCGTCGTGTTATTGAAAAACGCGGCCAACTCATAGAACTCTTTTTGGCTGAGCGGATCGAACTTGTGATCGTGGCAGACGGCGCAGCCAGCGGTCATGCCGAGCCAGGTCTGGGCGACCGTTTCGGTCCGTTCGCGGTTGTACAGGACGAGATATTCCTCCGCGATCGCGCCCCCTTCGTTCGTCGTGATGTTGCAACGATTGAAGCCCGAGGCAATCTGCTGATCGAGCGTGCGATTGGGGAGCAGATCGCCGGCGAGCTGCTCGACCGTGAAGACATCGAACCGCTTGTTCTCGTTGAAGGCCTTGATGACCCAATCGCGATAGGACCAGATCTCGCGATAGTTATCGAAGTGAATGCCATGCGTATCGGCGTAACGCGCAACGTCCAGCCAATGCCGGCCGCGATGCTCGCCCCATTGTGGCGATTCGAGCAATTTGTCAATCAGTTTCTCATACGCATTTGGCGATTCATCTTTTATGTAGGTTTCCACGACGGCCGGATCGGGCGGCAGACCGGTGATGTCGAGGCTCAGCCGCCGCGCAATCGTGCGTTTATCGGCTTCCAGCGCTGGCTTCAGTCCAAGCGATTCCAGCTTCGCGAGCACGAACGCATCGATCGGGTTTTTCGCCCAGGCTTTGTCCTTCACTTCGGGCAACGGCGGACGCACGGGCGCGATGAATGACCAATGCTTCTGATATTCCGCTCCCTCTGCGATCCATTGCTTCAGCAGTTCCTGCTGAGCCGGCTTGAGGCTCTTCTTCGTGGCCGGCGGCGGCATGATCTCTTTCGGATCAGTCGACATGATCCGGGCGATGAGGGCGCTCTCCGAGATTTTCCCCGGCACGATCGCCGTGCTCTCGATCGCCGCCTCGCGCTGGTCAAGCCGCAAATCGGCCTTGCGGGCCGCGGAATCGGCTCCGTGGCAGGCGAAGCAGTTATCGACCAGGATTGGCCGGATGTCGCGGTTGAACTCGATCTTGCCATCCGCGGCGGCAGCCAGTGACAAGAACTGCACGAGGGGAGCAACGATCGCAAGTGTGAGTCGTGGCATGGCGTATTTCAATGACTATAGGACGATGCGAGGTGAGGAGGAAGCTCACGCATAGGGACCATCACACAGGGACGGTCGGCGGGAACGGACTTTCACTTTTCTCAGGCTCCAATGCACTTTGCGCCTAAGGGAACGCGCCTGAGAGGACGTTCTTTCTCCATAGTAACGACAGGCAAGCCCGGCGTCCATTTTGAGGAGTGGGGAACCATTTGGCGCTGGTTCGTCCGTGCGCGGACTTAGGAATAGAATATGGGAATTGGCTCGCGGATTCCGTTAGAGCGATACCGGTGGCAACTGGTCCTCTGTGGTATTCTGGCGTGCAGTGTGTCACGACCTTCTGGATTTTTCTGCGCGAGTTCTCGCCAGTTTAGTCCATGCCCGTCCTGACTTGGCAGACCCGAGCCGTGGTTTCTCCGCGAGTCCCGCGTTGTAGCTTCGCTTTTCACCTCGCCGTTCCCAAGCCGCGCATACTCCGACCACGGACGACTCGTTTTTTTACTGTACCAAGCTCAGTTGAGGCTCACGGTCACCGGCTCACGCGCTACAGGTCCGCCTCCGGTTGGCCTCCGCTCGCGTCTGGCGGGCAATCGGGCCGTCCGCTGCCAGAGTTGCAGCGAACCAGTGGCCATCAGCAACTGACGCCGGTCGAACGAAGGAATCGGGCGAAGTTGGGTGCCGGTGGGCACGGACGTTGTCGGAAGCGATCTGAATGCCGGAAAACACTCCCCGGTTCGGGTGGCGTGGTGGTAGCCGCTGCCCCATAATGTCGCCATTCCCGGGATTTCCGGTTCGTCGGTGGCGAAAACTCGCGCACGAAAGTCCCGAATGTCGCGGCTCGCAGCACGGCTCTAAGCAATCAACACACAGCTGCGTATTAGATTGAAACACACCATGCTGCAACGTTCCGAAAAGTCCTCGAAGGTGCCACTGAATCACCAGCCGACCATCGCTATCCTGGGCGCGGGCGCTGCTGGCTTATGCATGGGGATGCGACTAAAGCAACTCAGCATAGAATCATTTACCATTTACGAAAAATCTGATCGCGTGGGGGGCACCTGGCGGGAAAACACTTATCCCGGGGCAGGCTGCGATGTCCCTTCGCACCTGTATTCCTTTTCGTTCGAGCCCAAGTTTGATTGGAGCCGCGTCTACTCGCGCCAGCCGGAGATTCAGCGTTATCTCGAACATTGCGCCCAAAAGTACGACCTGCACCGCCATGTGCGGTTTGGTTTCGAAGTCGCTAACGCCAGCTTCGACGAGGCGGCGGGTATCTGGCGTTTGCGAACCACCAGCGGTGAGGAGTTTACCGCCCAGGTGCTGATCACCGGAACGGGACAACTCAACCGGCCACATACGCCCGAGATTCCGGGGCTCGAAGAGTTTGGTGGTGCTCAATTTCATTCTGCCCGTTGGAATCACCAACACGATTTGGCCGGGCGCAACGTGGCAGTGATTGGCAACGCCGCCAGCGCGATTCAGTTTATTCCCCCGGTCGCGGAAGTTGCGAAAAAAGTACACGTTTTCCAGCGGCATGCCAACTGGATCATCCCGCGCAATGATCGTGCGTACCGCACGTGGGAGCGATTCGCGTTTCAATATGCGCCCGGTTACGCGCGGCTGATGCGGGCGTTGATCTACTGGAAATGTGAAAGCCGCTTTTTTGTTCTGTTCCGGAAAAGCTGGGTCGCCTGGTATCTGAAGTGGTGTGCCACCCGTTATCTTGAGTCGCACATTCAGGATCCCGCGCTGCGTAAAACGCTGACGCCTGATTTTACTCCCGGTTGCAAGCGAACGTTAATCTCCGACGACTACTACCAAGCTTTGGCTCGGCCAAATGTCGAGGTCGTTACGAACGGCATCGCGCGGATCACGCGAGATGGCATCATCACCAATGACGGAACGTTGCATGCTGCCGATACGCTTGTCTTTGCCACTGGTTTCGAGGCCACTCGCTTCCTGGCACCGATCGAAATCACGGGGCGCGAGGGGCGTCAACTTGCTGACGTATGGAAGCATGGTGCGGAGGCCTATCTGGGCGTGGCGGTGTCGGGTTTTCCCAATTTATTTCTACTCTATGGTCCGAACACAAACCTTGGACACAACTCGATCATTTTCATGATCGAGTGTCAGGTGAACTACATCCTGCAATGCCTGTCCCGTCTTCAGTCGCAGCGTTTGGCGACGTTGGAGGTCAAACCCGAGGTGCAAGATTCGTATAACCGCGAGCTCCAGCGCGGTCTCGCAAAAACCGCTTGGTACGCCGGATGCAGCAGTTGGTATAAAACGAAGGCCGGCAAAGTCACCAACAACTGGTCCGGATTCGCATCGCAATATTGGTGGCGCATGCGGCGTCCAGACCCTAACGCTTTTCATGCCGCCCCTGAGGTAACCTAACGCCCCGAGGGTGGCATTATTTTCTTGTGGATCTCGGTTCAATCTAACTGCTTCGGTGGCGGCCTGGATCGAGATTCAGTTTGTATTTGGAGTCATCACGGCGTTTCATAAAATCTTCGGGCTTTTCCCTGGCCAACGTGCGGTTGCCGGATGGGACTGCTAAGACACTGCTGCTGCGGGCCATTGACCGTTCCCGATCGCATTTCAGCCTGCGTCCTGTCCTCCGCATCATCGGTTTATCCCAGACAAGATTCTACGCCTGGAGCAACGAGACGCGTTGCAGCCTGGCCAACCAAGCGTCGTGTCCGCGCAGTTCGCCGTAGCAACTCACGGCCGCCGAAGTCGGCGTGATCCGGGACATGGTCACGGCCGATGAGTACCGACATGTGCCGACCAGAACGCTGGCCCGGTTGGCCCAGCGAATCGGCAAGGTCTTTGCTTCGGCGAACACCTGGCGCCGCTTGGTCCGGCTTCACAGCTGGCGCCGACCCCGACAACGCGTTTATCCAGCCAAGCCCAAAATCGGCATTCGAGCTTCGTGCGCCAACGAAATCTGGCACATCGACACCACGCGGAGCAGCACAACAAGCATCTCCCGCATGCCGCGTTTCATGGCCAGACACCCGACGCGATGTACTTCGGCACGGGGGCCGAAGTTCCGAAACAGTTGGCGGCTGCGAAAGTCGCGGCTCGGCAAGCGCGTCTGGTGGGTAATCGGGCCCTGCGTTGCCAAAGCTGCAGCCAGTCCGTTGCCGCCATTAACTGAAGTCGGTCGAACGAAGGAATCGGGCGAAGGTGGGTGCCGGTGCGCGCGAACGGCTTGAAAGGTGCTCCGGCCAGCGGACAAGCCGTCGTTCCGAGGAGTTTAGCCGCGATTCTCTTGCCCGGGCTCGCACATCTTTTGGCCTCCCGCACCCCAAGTGGCGAGAACTCGCGCAGAAAGTCCCAAATGTTGTGGTTGTCAGCACGGCGAGAACTCGCGCGGAAAGTCCCAAATGTCGTGACACGCAGCACGCATAATTTTTTTCGCACGCCGGGCTGCGCCAGTCGAGAGAGAGAGAGAGAGAGAGAGAGAGGAACAGAGAACAGAATTACAGAGATCAGCAAATCAGAGATTCAGAGTACGACGACTGGAAGCCAAGCCCCTACCACACCCGCACGACACGAAAACCGCTGACGTTGTTACGGTGCGACGGCGAGTTGTTGCCGCGATACGCAGACCGACAGTAGGAAGCGTAGTAGTTCCAGTGGCCGCCACGGAGCACGCGATCGGAGCCGGAAAATGGGCCATTTGGGTCGTTGGCGAGGGTCTTCTCGTGCCACTTTTCGTCGTAGTAATCTTGGCACCACTCCCATACATTGCCATGCATGTCGGACAGGCCGAACGGGTTGGGCAGCTTGGTTCCCACCGCATGCGTTCGACCGCCATGGTTTTTGTTGTACCAACCATATTGCTCTAACTGCTGGTGGTCGTCGCCAAACGAATACTGCGTCGTCGTACCAGCCCGACAGGCGTATTCCCATTCGGCTTCGGTCGGCAAACGATAGCCATTCTTGTTCGGTTGCAACTGACTGGTGTTCCCGTTCAGCACATAACAGGGATCGAGTTTTTCTTGCACAGAAAGCCAATTGCAGTAGGCCACTGCATCGTTCCAGGTAATCACCGCCGCGGGTGAATCGTCCGCCACAACGTAGCCGGGTTTGAGGTAAGTCTGGATCGGTTTGGCCGGCTGACCAGGAACGACCGGCGGTGGAGACGCCTTAGCTTTGAGCTCTTCTTGCTCGGCTGCGGTGACGTAGCCAGAGGCAGAGAAGTTCTTGAACTGGCCCACCGTCACTTCCGTGGCACCCATGAGGAAGGGCTTGGTGATCACGACCTGATGCTGGGGGCGCTCCGCCTTTTCGATGCGGTCTTTTGTACCTTGATCGGCTTTGGTTTCCTCCGCTGCCTTGAGAGCAGCTGCAACTTGCTCATCCGTGCTGCCCATCATGAACTCGCCGGGCGGGATGAGAACCATTTTCATGCCGACGCTGTTGGTCGTCTCGACCTCGGTGCCGAGATGCTTGGCCCAGGCTTGTTGATGTTGCTTGGCTTGAGCGGCGTCGAAGGGGGCTTTAGCGAGTGGCGGGACGGGGCTAGTCGCCGTTAGGAAGGAAACGGCAGGCGATTTCGATGTCGAAGCGGTCGCAACTGCTCCCAGATTCGATGAGTCGGCCTTCACCCACTTCGCCCCGACGATCTTGGCGTGATGCTTATTGTCCGACGAATCAAAGGCCGTGTCGCCGCTGCCCTCGTCGAAGTGATAGAGGGCAATGGTATCGGCGTCGGGAGTGAAGCGAGGATCGGGTTTGAAGTCGCCGGTGTAGCGGGCGACCTTGGAGATGCGAACTTCGTCGATGATGCCGTCGAAGACGGCAGAAGGACTTACAGGTAGTTGCGGCCCTTTTTTTCCTGTTGGGTCGGCCCCAATGACGATTTGATACGGGCGACTAACGAATTCCTGGTCTGCCACCGATGCACCTTGTAATACTCCATCCTTGAATAACCGGATGCTCGTTCCATCAAACACTGCCGCAAGATGACTTTTCTCGCCTTCGACTTCCGCCAGCGATACTTGGGTCGTCGTTTGTGATTTTGTTAGGGAACTGGCGGCCCATTTCGACTTCACAATTTCGAGGCTAAAACCGGTGTCGCTTGCATTTGATATGACCGTGCCCACCTTTCTGTTGCGAGCCACTACAAATGCTTCGACCGTGAGTGGACCATCGTTCTTGTAAACCAGTGGCGTATAGACAAAGCTCGACTTTCCATCGAAATCCAGAGCGACTTCATTCGTAGTCGATTGCATCTTCACGGATACCAACTTCGCCGTAATCGCTTTCTTGCCGCCCGACTCCATCTCGAACTCTTGGCCGAATACAACGAATCCATTTTTCTCAACACGCAGACGATGCTTGCCTGGATCGACGCTGATCGTGACTTTGCCAGCCACGCCTTTCTGACTGACCTCGACTTTGCCTTCCGAGTCCAACACCTGCACCATCGCATCGGGCTGATCGACTTCGACGATGAGCGTGCCGTCCTTGGTTTGGAGTGAAACGATGATGCCCGCCAGGACCAACACGCCGAGGAACGCCGCACCGATCAGCACCTTGGTGTTCTTCCACGGTGGCTGCTTCCCATCGTTCGACTTGGCAGCGGCGATCTTCTTAGTGGCCTTCGACTTATGAAGCGTCTGCTGGATCGGCATGTCCTTGAGGAACGTCAACGCACTGTTTTCACAATTAGTGCTGGCCGCTTGCGAAGTCCCGAGTGATGTCTGCGAGCGGCCGCCAAGTCGCTCCAGGTCAGCGATCACTTCGCTCATCGACTGGTAGCGATCTTCGAGCTTCTTAGCCAGCATCTTGCTGAAGACGGATTCCAGTTCTGCCGAGGCTTCGCTACATGCCTTGCGAAGTTCTGGAATGGGATGAGCTTGATGAGCGACGAGCTTGGCCGTGATCGTCTCGCCCTCGAATGTCGGCTTGCCGGTCAACAGATAGAAGAGCGAACAGCCCAGGCTGTAGATGTCGGCCCGTGCGTCGGCACTCTTGGTACTCATGGCCTGCTCGGGGGCCATGTAGTCCACGGTTCCCATCACCGCCCCGGTGCCGGTCAGTTCGGCTTGGGTGGCCGTTTCGCCGTCCGACTCGATGCGAGCCAAGCCCATGTCGAGGATCTTAACGACGCCCTTTTTGTCCAAGAGCAGGTTGGCGGGCTTGATGTCTCGATGGACGACGCCTTCGCCGTGAGCGAACTCCAGTCCACGAGCGGCTTGCAAGATGTAGTTGGTCGCTTTGGCGACGGGGAACGCACCGTTCTTCTTCACCAACGCCGAGAGGTCTTGTCCTTCGACGTATTCCATAACCAGGAAGTGGACGCCATTGGCTTGGCCAGCATCGTGAGCGGCGACGATGTTGGGATGACTCAGCTTGGCAGCGGCTCTGACTTCACGTTCAAAGCGGGCAATCGCGGCTGCATCTTTCATCGTCGCACTTGGCAACATCTTGATCGCCACGGTGCGATCCATACGCCTGTGAAGTGCTTTCAGGACTTGCCCCATACCGCCAGCCCCGATGCGATCCAGGATGGTGTACTCACCGAGGATCAGTGACTTGGATTTCCCGGCGGCAACCTGAGCCGCCTGAAACTTGGTCAGGTGATGCTCTTTGACCAATTGAGCGACGAGTTCGTGGGCGTCCTTGGGAGCGGCTTTGGGCGGAATGAAGTTTTCGAGTTTGCCCTGGGCAACGATCCCGCTGTCTTCGAGCTGCTTGACGACGGTTTCGAGGGCGACGGCCATAATACTTCTTATCGTGCGGTTACTTGGTGCCGGATGCGGCGGGAGTCGGTGCGGCGGGTTTGGCCGGATCGTCCCACTCGATTTTGCAGTTGGGCAGGGCTTTTTGCAGAGCGGCGACTTGGGTCACGATTTCGCGACTACTTCCCGTCAATTTTTCTCCAAAAACTCTGTGGACGGCTTGAAGTTGATCCGCTCCAGCGTCTTGATGGAACGGAGTAGTTCCTTGTCCCGTTCGGGATTGTAGTTCAACTGGATATCTTTCAATGGCATGCCGGCCAACACCGACAGGTCCGAGACTTTCATCGCACCAAAAGAGCCGATAGCAAAGCTTTCCAGTTTCATCTCCTTGAGGGGCGATAGATCAACAAGTTGGCGGCAATCAAATAGATCTAGGTTCTTTAGGTTGATGCCCCTAAGCGGTGATAGATCGACAATCGGCGTTTCTCGAAGGTTGAGCGTCGTCAACGCCATATCCTGTAGCGGCGTCAGATCGGACACAGACTTACATCCTGAGCAATCCAAATCGTTCAAAGGCATGCTTTTGAGTGGGGTGAGGTCGGAGAGGAATTTCTGACCTCGGATGGAGAGACTTGTCAGTTGCATCCCTGTAAGTGGCGAGATGTCTCGGAGAATGCCATTCGCTGGTCCCTGTGGCACATGGCATGATAGTTTCTTCAATCCCGCAAAGGCTCTTAACGGCGAGATGTCGAGCAATTGGCTGCTAACAAGTGCTACTTGCGTGACCACGCCGTTCTCGACCTTGGGCTTTCCCTTTACAGCGGACGGCCCAGCGTCAGCCCCCATCGCTCCATCAAACCCCGGATTCAACTCCACCAGCTTCTTGCTCACCGCTTCGATCTGCTGCTCGGCACTCATCGCCTGCACGTCCTTCATCCACTGCGGGAAGGCGGGGTCGTGCATGAAGAGTTTGGCGGATGCAGCGGCGGGGACGGCGGGCTGCGGCGTGACGCTCGCCGTCGTTGATGGGGCGTTGAACACCCGCACGATGCGGAAACCGGCAGTACCTATTTGGTTAGTCGCCGGTTCATGGTTTCTAAACGCACTGCGGGTCGTAGGAGGGATGCTGTTCCATGCACCACCACGGAGCACACGCAATCTGCCGGTTAATGGACCAACTGGATTCTCTAGCGTTAACTTTTCATACGACTTTTCATCGTAGAAGTCTTGGCACCACTCGACCAAATTGCCGTGCGTATCAAACAAGCCGAAAGCGTTGGGTAGTTTCATGCCCACGGGCCGGGGATTGGTTTTCGCGTTCTGGTTATACCAAGCATAATTTTCTAACTCGGCGTGATCGTCGCCAAACGAATACTGCGTCGTCGTGCCCGCTCGACAGGCGTATTCCCACTCAGCTTCTGTTGGTAAGCGATATTGTGTCTTCTCTTCGTCAGAGAGCCACTTGCAATAAGCCAATGCCTCGTACGAGGAAATAGCTGCGGCCGGTGAGTCGTCTGTCACAGAGTAGCCGGGATTGAGATAAGTCAAGATTGGTGAGCCCGCGTCGGTCGGTGTTTGACCGGGTGATTGGATAGTTTTAGATGCTGCCCCTGCTCTTTGTTCCGCATCAGTTAGAAAACCCGTAGCGGAAAACTTCTTAAACTCGCCAACGGTGACTTCTGTGGCTCCAATCCAGTATGGCCTCGTAATTACGACTCGATGCCGTGGTCGCTCATCTTTTTGAATCCAGTCTTTATGAAATTGGACCGCATTGAATTTGTCTGCCACCTTCAACGCCGCCTCGACCTGCTCATCGGTCGAACCCATTTGGAACTCGCCGGGAGGAATCAGCACCATCTTCGCCCCGACTGAGTTCACCGTCTCGATCTGCGTGCCGAGATGCTTGGCCCAGGCTTGTTGATGGGCCTTGGCCTGAGCGGCGTCGAAGGGGGCTTTGGCGAGGGGCGGCGTGGCGCCAGCGGTTTTGATTGCGGGTGCGGGTGTGACGACCGGCGGAGTACTTGGCGGGCCGTTCGCCGTCGTCGCCGGGGCGTCGAGAACCGACACGCAGCGAAAACCGGGGCGGGGCGACGGCGTGTTGTTGGTGCGATAAGCACTGCGACAGTGGGAAGCGGGGAAGTTCCAGTTGCCGCCACGGATCACGCGATTGGAGCCGGCGGATGGGCCGTTTGGGTCGTTTAGCGGGGATGCCGCATACCATTTCTCGTCGAAATAATCGCCGCACCATTCGTACTGATTGCCGTGCATGTCGAACAGGCCGAATGGGTTCGGCAACAGCGTACCGACCGGATGCGATTTGCCACCGGCGTTCTTGTTGTGCCAACCGTACTTGGGCAATTCGTTGTAGTCGTCACCAAAACTGTATTGCATCGTCGTCCCGGCGCGGCAGGCATATTCCCACTCGGCTTCGGTCGGCAAGCGGTAGGTTCTTTTTTCTTGTGTTGAAAGCCACTGACAATAGGCCGTGGCGTCGTTCCAGGTGATGTAGGCGGCCGGCGAATCGTCGGTTAAGTCGGGGCGGTGATTAAGATAATTTGGGGTCGGCTTCGGCGATGGCTGGCCCGCCTCGACCGGCGGCGGAGACGCAGCATTGGCGGCGGCCTCGGCTTTCTCCGCTTCGGTTTGGTAGCCCGTGGCACTGAACTTCTTGAACTGTCCGATCGTTACTTCGGTTGCACTCATCAGCAGCGGCTTGGTAATGACTACCTTGTGTTGCGGACGTTCGGCCTTTTCGATGCGGCTGATGACTCCGCCATCGGCCTTGATTTCGTCGGCCGCTTTCAACGCCGCTTCAACTTGCTCGTCCGTGCTCCCCATCATGAACTCACCCGGCGGTATGAGGACCATCTTCGCGCCGACGCTATTGGTGGTTTCGATCTCCGTACCCAGATACTGGGCCCAGGCGGCTTGATGGGCCTTGGCTTGAGCGGCGTCGAAGGGAGCTTTAGCGAGGGGAGGAGGCTTGCCAACGGGTGTGCTTGGCGGGAGATCGTTCCCTTTGGTTTGGATCGTCGCCGATCCTCCGTCTGGCACCTCAATTCTGGCGACTTCTTTGCCATCTTTGTCGCGAATGATAACCCAGACGCCGAGGGCGAGCAGCAAGAACCCACCCAGCCCGCCTGCCATAACGACAAGCGGTTGCCGCCACCAAGGCCCCTGGGGCCGCTGCGGCGGGCGGCTGCCGGCCACCTGGATCGAACGATCGGAAATCGGCTCGGTTGTGACTTGAGCGCTGGCGACCGCGATCGTCGGGGATAGTTCGTCCATTGTCTTGGCCGCCGTGCGCGGCCTCTGTGCAGTTGCGACTCCGCCGGTGACTGGCATGGGCTTTTTTCCCATGAACGATTGCAGGAATGAACCAAGTTTGCTGTCGGCTTCGGGCTTCGCCGAGGAACTGGCGGCGGGCGGTGGACTGGCGAGCAGCGCGAGAGCCGCTTCCACCTCAGCCATCGTTTGGTAGCGGTCAGCGGGCTTCTTCGCGACCATGCGTTCGAAGATCGTCACCAGGGCCTTGGGAGTATCGGGCCGCTGAGTGGCCAGCGAGGGAATCGGTTTGCTCTGGTGCCCCATCAGCTTCTGCACCATCGTTTCGCCGTCGTACATGTTCTGGCCGGTGAGCAAGCGATAGAGCGTGCAACCGAGCGAGTAGGTGTCCGCCCGAGCGTCGGCGTGGCGAGTATCGAACGCCTGCTCCGGAGCCATGTAGTCAACGGTCCCCATCACGTCGCCCGATTTGGTGAGCCCTTCCTGGGCGGCCACGCCATCTTCGAAGCGGGCCAAGCCCATGTCGAGGATTTTGATCGTCCCCTTCTTATCCAGCAGCAAGTTGGCCGGCTTGATGTCGCGGTGGACGACGCCGTTTTCATGCGCGAAGGCGAGCCCCTTGGCTGATTGCCGGATGTAATCGATCGCGCGAGCCACCGGCAGCGGGCCTTCGTGAGCGACGACGCCCGACAAATCGCGCCCTTCGACGTACTCCATCACCAGGTACCAGACGCCGCGTTGTACGCCGGCGTCGTAGGTCTGCACGATGTTGGGATGCGTGAGCTTCGCTGCCGCTTCGACTTCCCGCTCAAATCGTTTGATGGCGGCTTCGTCTTTGGTCAGCGAAGTCGGTAGTAGCTTGATCGCCGCTAGGCGCTTCATCCGGCGATGGTGGGCCTTAAACACCTGCCCCATGCCGCCGGCCCCGATCTTGGCCAGCAGCACATAGTCGCCCAGCACCAGCGGCGTCTGCGAACCGGACAACAATTCCTCGGCCTGAAACTTGGTCAGCTTCTCACGTTCGATCAGCACCTTGGCGAAGGTCTCGCCGTCTTTGGGGCGAGAACCAGCTGGCAGCGAACTCCACAGCGACTTGATTTCATCGGCCGACGAAAGCCCCGCGGCGATCAGGGCTTTGGCGAATTGGTCGGCAGTCTGAGGCACAGCGAGTTCTCCCGAGGCCCGCCATTCTAACCAGGCCTGCGGTCATCCGCAGCAGAGAATCAGCGACTGAAGTTGCGATGGTGCGCGGCTGGCAATCGGCATCGCGGAAGCGCGCCGCTGTTAACGGGCTGCAGCAATAGTTCGAAGAGCGTCGCGACCGTTTTTGCCACCGCAACGGACTCGAACTCCACAAGTGCCGACTCAAAAGCACTTACGAAAATCGCAAAAGAGAGTACTGTTACGTAGAGGGTTATGCACAGGGAGCGGGCCCTCGTTCCATGATGGCAACGGGTCATCGGCGTGAGCGTTGGAAGTGAATGACGTCGCGATGATGGAAACAGCGACAACCATTGAAGCTATAAACATTCTGAGCTTCATGATGCTACATTCCGAGGTGGTTGAATGCGGAGCAAAGGGCAGCACCTGTGTTTCCACGGGTGCGCCCAAATGACAAGTCAATGTGTCGTGCGGCGTGGTATCATTTGCCGCCGGCCGTCATTCCCTTGATCTGTTTTTCCAGCGATTCGAGGCTCCAGTCGCCTGGCATCTGGCTCGGCGGGAATTCCTTCATGGTCATGAGGAACTTGCTGGCGACCATCTGCATGGGCCCAAGTACATAAGCCCGGTCGATCATCCAGTCGTGATAGGTGTTCGAATTCTCGTAGGCTTTCTCGAAGGGGTCGCGACGCAGGTTGAAGAGCAGGGGCATGCGCAGCTTCACGAGGGGTTCGCGCCAGACCTGGAGCTGACGGGCGCGATTCTCGAGGTAGGTCGCCTTCCAGTCACCCACGCGGATTGCCATCATGTCGCCGTCGTCGCCGACATAGAAGAACTCATTGCGGGGCGATTTCTTCACCTTGCCGCTGAGGTAATCGGTCAGGTTGTAGCCATCGACGTGGTTCTTATAGTGCCGGCCATTGAGGTCCGCGCCTTTGAGGAGCTGTTCCTTGATGTTGGGATTTCCGGCGGCGGCGGCGAAGGTGGGAAACCAATCTTCGTGCGACACGATGCCGTTGAGCGTCACGCCCGGCGGGAAGTGGCCGGGCCATTTGATGAGGCAGGGCACTCGGAAGGCACCTTCCCAGTTGGAGTTCTTCTCGCCATGAAAGGGCGTGGTGCCGGCGTCGGGCCAGGTGTTGTAGTGCGGACCATTATCGGTCGAGTATTGCACGATGGTGTTGTCGGCCAAGCCCAGTTCATCGATCAGTTCCAGCAGTTCGCCGACGTGCATGTCATGCTCGACCATGCCATCGCCATATTCATCCTGCCCTGAGATACCGATGTGTTCAGGCTTCACGTGCGTGCGGAAGTGCATCCGGGTGCCGTTCCACCAGCAAAAGAACGGCTGGCCAGCCTTAGCCTGACGGGTGATGAAGTTCTTGGCGGCGGCCATGGATTCATCATCGATGGTCTCCATCCGCTTCTTGGTAAGCGGGCCGAGGTTCTCGATGGTCTGGCCACCCTTGCCGTCAGCCTTGGATTTGATCACTCCGCGCGGACCGAACTGCTCGAGGAAGGTTTTGCCGTTGGCCAGTTTCATGTCCCGCGGGTAGTCGCGTTGCTCGGGTTCTTCCTCTGCGTTGAGGTGGTAGAGGCTGCCGAGGAACTCATCGAAGCCGTGCATGGTTGGCAGGTGCTCATCGCGATCGCCCTGGTGGTTCTTGCCGAACTGGCCTGTGGCGTAACCCTGGCTCTTTAGCACGGTGGCCATGGTACAGTCGGTCTTCTGCCAGCCTTGAGGGGCGTTGGGCATGCCGACCTTCGTCATGCCCGAGCGCACCGGCACGCTGCCGCTGATGAACGCAGCGCGGCCGGCGGTGCAGCTTTGCTGGCCGTAGTAATCGGTGAAGGCGACGCCTTCTTTAGCCAGGCGGTCGATGTGGGGCGTCTTGTAGCCCATCATGCCACGGTTGTTGTGGCTGATGTTCCAGGTGCCAATGTCATCGCCCCAGATGACGAGGATGTTGGGTTTCTTGCTTTGAGCCTGAGCCGAAGCCAGGGCGGTTAAGCAAGCCAGCCCGAAGACCAACGTAAAAGTGCCAAGTTTCATCGTGAGGATTCCTCTTGTCTGATTGATCTGTCCCAGCGACCGCCGCGGTTGATTACGAAATGCCACTATCGATAAGGCACATCCTATACCGCAATCAGCTCAGTTGATGGGGGCCTATGTGGACTCATTCCGGTCCAGTGAACGGTGGCGGCAAACCAAATGAGCACATGCCAGTGAGCGATTACTCACACTTTGGCTGGTGGTGAGTGACTCCTGCGCGCCACCAGGTCAGTTCCGGGCAACTCTTCGCTCGCTCGTGGTCGGGGCCATTCTGGCCTTGGGCGTCCTGCGCACAACGCGACTCGGTCATATCGGCCGAGGTTCCTCATCGTCTCAAAAAGTTACTGTGCGCTCAGATTGAGGCGATGCTTTGAACCTGCCACAATCACCTGCGGTCCGTAGGGTTTCCCTCGGGCTACGGGAGAAAGTTTTATGAATGCTGGCACACCCCATTCGCCGATGCGTCGCCGGCGATTCCTGCAAGCCACCGCCGCTGTTACAGCGACCGGGTTGATGCTTCCCGTCCCCAGACTGCATGCAGCGACCGCCACTCGGGAAACCGACCACTTCTGGTTTCGACTTGCCGCGGAGGGGCCTTACATCGATTCGCAGCGCGAACACAGAGCTTTTGGGTTCGGCGACGGCAAGATCTATTTGTCCGAGGATAACGCCAGAACCTGGGCGTACAGTGCTGACTTTCCGGACGCCGAAAACATCACCTTCAGTTGCCTGCTAAAAAACGGCAACGTCTTGTTCGCCACGCGCGAGAAGCTGTTCTTAAGCACTGACAACCTCGCCACGCATCGGCAGATCATCGTCAAGGACCGCGCGGGCCGAGATTACCTACCGCATACACCTCGCAACCCGGATTTGCCTGGCTGGTATTTCCACTCGCTCGACGGCATTCACACCTGGGACATCGACGGCTCTGAAATGCTGGTCTGGGGCAATTACTGCAATGTGCTCGGCGGGCCGGTGCCAGTGAATATCTACTACTCGACTGACAGCGGGCAGACGGTCAAGATCGCCTATGCTTTCGGCCGCAACCCTCACTTCCAGGAGAAGGGAGCTGAACCGGGATTGTTCCTTGGCGATCCAACCAACCCTGTCATTTGCCGGCACTTGCATGCCGTCGCCTACAATCCGGTCGAGAGAGCGTTCTACGCTTGCACCGGCGACGTCAATCGAGGTCATGGCAACGAATGCCACTGGTTGCGCGGCGTGTACGACGCGCGCTCGGACACGTGGGATTGGCGAGTCGTGGTCTCCGTGAACTCGAACTCGCGTTACAAGTCGGGTGGCATCAACTTCGTCGATGGTCAACTCTACTGGGCCGCCGATGCGAACGGCCGTAAGTCGCCGGAGGAATCTTACGACCGTGGCATCTTCCGCTGTGCGCCTGCCGATCTTGCCGATCCGAAGAAGCACACACGGTTGTTCGCTGCAGAATTTGAAATGGCCAACATGGTCATCGAAGACGGCGTGATCCTGGCAGGTCATTGCGCGCCGGCCTCCACCTACAAAACGGGCATCGCCATCTCGCTCGACATGGGCAAGACTTGGGCTGAATACGACTTGGCTGAGTTCGGGGCACGTTCTCCCGTCCGCTTTCATCCTAAAAACAGCGACGGCTGGTTTCGCGTGGACCTGCGAAAGGGATGGATTGAACGAGCAGAGGTTCTGTTGATCAAACCAAAGCGGTGACAACATGGAAATTCTGCCGTTCGTTCTGAAGTCCGCGGCACATGCGCACGTCACCGAGCAAACGCCGACTCGATTGTGAAGGTCGCAGGTCATTCACACTTGCCGACTGAGTCGGCGCCGGTACGGTGCGGGCGTAATTTCGTCGGTCAATTGATCGACTGATACGTTAACACCTCGTGTCACTGCGTCACTGGTACCGCTGACTTCGTCGCTGCAGCCAGGGACTACTGCCCAGCGACCTGCAAATCGATTGAGGAGATGTGGCGCAGGTCGCCGGACTGTGCTGAGTGGCTAATTCGGTTCGGCAACTCGCGTTCGAGAAGGATGGCGTGCTTTATGCAAAACAGCGAGGGTGTTCTCGATGGCCCGGTGGTTCACTTACTTGCGGCGGCCTGCCGCCACCGCCCGCCACAAAAACCTAGCAGCGGGCGGCGATCTCGATCCGGCGGAATCGCCACGTCTGCTCCCAGCCTTACGCAGCCGGGTTCTTAGGAAGAATCAGCGGCGGCAGTTTTTTCGCCGGCCGCAGGGAAGCCGGTTCCTCGATCTCGGCGTTCCGAGCAGCTTTGTGCGCTGCAGCCACCTTGGCAATCACATCAGTCAGCGACTGCTTGCCCAGCGTCGGACGGTATTCGCGATCCTCCGCATCAAGACGAGGCGACCGACTGATCAAACTCATCAGTAAGGGCACAACCAATTCGGCGTCCTTGCTCCTCCTGAACCAAGTGAACACCTTCAACCGATCGCCGATGTTTTCCTCGATGAACCGTTTGATCGGCTTGAAATACACGGCCACATCGAGGCTGGCCACCAGAAACCGATCTAGCGCTTCTTCGGGTGTGGGAGGCTGGCGTTGCTTTTCGGGAAGCCTCGCTTCAAGCAGCTCCCGAGCCCGCTTCTTCACATTGCCACCGCTGATAGCCAACTGCCGCAGTTCCTCAGTCTCTGCTTCGGTTGCGTGGTCCAGGATCGCCTGGCCCACCTGCTGCGAGAGCTTCTTGCGGTCGACCAGCCGCCGCAGTTCCAACGGCAACGCCATCAGATCCCAATAACGCTCCATGGTCACACGTTTCACGTTGCGGCGCTCGCCGACTTCCTTCAGCAGCTTATCTTTTTCAACCTCTTCGCCCCTCCCCCGTTGCGCCTCGATGGTCAAGCCAAGCTCCTCCAGAGGTGGCAGATGGCGCCGATTCAGGTTGGCCTCGATCAGCCGGACTTTGATTGCTGCGTCGCCCTGCGAGTCGAGGTCATACCGCACCTTTACCTCGATCGTTTCCCATTGCGGAAGATTACGGTCGATAACCAAGCGGCGCAGGGCTGACAGGCGACGATGGCCCGAGATTACCGTACCATCCGACGTAATCTCGACGACCTCAGTGAGGCCGTTAGCCAGAATCTGGTCGCAAAGCTTTTCCAGATCCGCACCGTTCTCGGGCGGAAAGAAGTGTTTCTGGTCAGGGTGATCTTTCAACGCGAAAATGTTTCGCAATTCATGCTGGGGAACCGAGACAGATGTGCTCGGCGAAATGGACTTCGGCTTCTTCTCCACCAGAGGCGGGAGTGGCTTCGCTGGGAGCTGACCTTTCGATCCCGCTGTGTTCCGCATCAGCGTTGGAAGTGGCTTGAGCATTCAATGGCCTTTCGACGGTTGCGACGACACGTTTGGTCGTTAAGAAATGGGTTGAAGCAGCAAGAACAGTTGTTGCTTCGAGCTATGGCAGGAAAATACGCGATCGCAGACTAATCCGAAGCCGCCGGAGAGAAGCGGCTTCGACAAATTATTAGGAGCAAACGCGAACAAGAACAGCGTGTCCAGGCATCAAAAAAGCAAACTTGTGCGACGAATGCCTTTCTTCCATTTACAACGAGCGCAGAGGTTGCTTTCAAATGTTCTTGGTTAGATTGGAGCCAAATCAACGGCGGTCTCCAGCAGGCGTGTCTGAGCATCTGTTGTCCAGTACAAAGGCAGTTGCTAGCTCGCCAGACTTTTTTGTTGACTCGGTTTCACCTGGAAGCTCGCCGGTAATGGTGGAGTAATGAGGTACACCACTTCGGTCGTTCTGGACATTTAGATCAGGTTACTTAACGGCCAACTGAACCATTTGGGCAATCACTTGGCGCGCCGTCACGGGCAGGTTGGGCCACAGGTCGATCACAATTTGTAATTCGGCATCGAGCGTCACAGCGCATTCATTGTCCCTGTTGTTGGTGCAAACCCTGGTGCAACTGCCAATTGCACCTTCCGTAAGTTGTTGGCTTATAATGCGTTGGAAATCTAGTCCGCGGGACTGTCGATCAGGTGGTTACGCGTTCGAGCCCCGTCGACCTCCCTCTGAATGCTGCCCTTGGTTTTCCAAGGGTTTTGTCGTTTCTTGACCAAGGTCTGGAGGAAGTGCTGCAGTCCACGCGAAAATCCAACAGGCAGGGAAACTACACGAGTCCAGCGTCGTATGGGGTGAAAAACAATCGTTCATCGGTATCAAACGTGGTTCCGAGTCGCTCGGCGGCAGATTTCGAGCTATTTCCCTGAGCGTTGCCGCGCGTCCTTCTTGGCAGGCTGGTCGTCGCCATTGAATAAGGCTGGGAGTGGCAGGTAATCGAAATCGAGAATCATTTTTTCCGCGAGCGCTTCTCGTAGTTCTCGCTCGATGGCAGCGACTTCCGGTTTGCCGCTGAGGTTTTGCAACTCGGATGGATCGGCCTGCAGATCGTACAGTTCGTAGACTGGTCGGGGGACAGTGAAATAGGTCGCTCGTAAACCAGCCGGCAACTTCCCAGCGGTGTTGGCCGCTTGCATCTCCTTCCAGCCCAAACCGCCGGCGGAGTCAACCGGCGAATAAGGCAGCCACGGCGTGCAGTTGTAGATGAATTTGTAGCGATCGCTGCGCACTGCGCGGCCAAGGTCATAACCGGCATTGGTCATGTTGACCGCGACCGGAGCCGAGCCGTGCGGTCCCCGTTCGATGAACACATGCTTGCGCGGTTCGTACTTTTCTCCTTTGAGTAGCGGCAAGAAACTGCAGCCGCTCATTTTGGTTCCGGGTGCCACCCAACGCCGTGAACCCTTTTTGGCGAGAGTGAAAAAGTCTTGATGCGATTGAGGTTAGTGGCGATGCTTTCGTTTCTCACCGCGAAAGGATCGTTCACCGCTCACCCGAAAGGATTCGGGAATGTCGCATCAAGACCCTAGTCGAAGTCAGCAAGGTCGAAGTCAGGTTGTCGTTGCCGAGTTCCAAGCGGATCAGCTCAAGCAGTCACTGGAGCGATTGCTCGGCGAGGGGGACTGGGGTGCGATTCGGTTTCGTGACGACTGCACGTGGGGCCCACGGCAATTGGCGGCCACGGCGTTGCTCTGGGCTTGGTCGGATGAACTCACGCTGGGGGACCGCTTCTTTGCTGCCCGCAGATTAGCTCAATTTCTGTTTGCGCCGCAACAGGAGTTTGCCAGTTCGGTGCAAGCCTTCATGAAGTTGCTGCTGCGTTGGACGGTGCTGCTGGTCGGCGTATTGCAGGTGACGTTTCGACGGCAGATGCAGCGTGCATTACCCACCCTTTGGCGAGTTCATGGCCTGGTCCTCTTCGGCATTGATGGCAGCCGAGTCGACGTGCCGCGAAGCAAGTCACACGAGGCGGCACATGCTCCGGTTCGCGATGGTAAGGGACGAAAACTCAAACGCAATCGTCGCCAGAAACCGCGCACCGCGATTCACTCGCGCAAGGCAAGCGTCCCGCAAATGTGGTTGACCCTGCTGTTTCACGTCGGCACAGGACTGCCTTGGTCGTGGCGAATCGGTCCGACCGGCAGTAGCGAGCGCGAGCATTGGTTGGCGATGCTCGACGAACTTCCGAGCAATGCCCTGATCACCGCCGATGCTGGCTTCGTGGGTTACGATTGTCTGCGCGCCGTTGTTAACAGTGGTCGCCATTTCCTGGTGCGAGTCGGTTCGAATGTGCGTCTGCTGTACAAGCTGGGCTTCTCCCGCGAAGTCGTTGGCACGGTGTATCTCTGGCCCGATCGTGCTGCCCGTCGCAGTCAGCCGCCGCTCGTGTTACGCCTCGTCGTGGCCACTGGTGGAAAGTATCCGGTCTACTTGCTCACCAGCGTCGGAGAAGAAGAATTATCGCGCGGACAAGTCCTCGACGTTTACCGTCGTCGCTGGGGCGTGGAACTCTTCTTTCGCCACTTGAAGCAAACGTATCAGCGCCGCAAACTTCGCAGCACCAATGCCGCGCATGCGCGTTTGGAGTTGGAGTGGTCGCTGCTGGGACTATGGAGCATGGCGCTCGATGCTCAGGTCCAAGCGACGCGCGTACAACTAGATCCTACTCAACTCAGCCTAGCGGGCGTCTGGCGCACGTATCGGCGGCTGATGCGCGACTATCGACATCCGCTGGCTCGGCAACAATCGCTCCCCCACCAACTCCCTCAAGCAGTGCGCGACACCTACGAGCGAGCCAACAAATCCAGCCGCAACTATCCTCGCAAAAAACGTCCCGACCCGCCCGCTGGCTCTCCCGAGTTCCTACTCGCTACCAAGTCCCAAATCCATCGCGCCCGCTACCTCACGACCGCTGCCTAA

Protein sequences of DBSCAN-SWA_1

>NZ_CP036274|8219694:8277082|8249606_8250605_-|WP_145098457.1|DBSCAN-SWA
MFDFDHVSGVYRSFADNECQGYSDLYFNLAHAVAAKEELVAFLSPLPVIQPNLFLAAIQYLAGQEWMPKSAKELEVFVQRRGVEIATLMKLRRTQTNEVGRCAVLLPALPDGPLALLEVGASAGLCLLLDEFYYDYGDTKIGIPESPVRLRCQTQGVLPLPEKLPQVVWRAGLDLAPVNLRDQTDARWMSSCVFADHVERQQRLQAAMDLGRRREVKVHQGNLVTDLRQLIDIAPDHAQLVVFHSAVLSYVSPQERNIFASNMADASRARDIIWISNESRSVVPEIAALAPPSGPRPFLLGRTTFHRGERRDEFLALAHPHGAELEWLHPRY
>NZ_CP036274|8219694:8277082|8275020_8275533_-|WP_145098493.1|DBSCAN-SWA
MSGCSFLPLLKGEKYEPRKHVFIERGPHGSAPVAVNMTNAGYDLGRAVRSDRYKFIYNCTPWLPYSPVDSAGGLGWKEMQAANTAGKLPAGLRATYFTVPRPVYELYDLQADPSELQNLSGKPEVAAIERELREALAEKMILDFDYLPLPALFNGDDQPAKKDARQRSGK
>NZ_CP036274|8219694:8277082|8271230_8272502_+|WP_145098487.1|DBSCAN-SWA
MNAGTPHSPMRRRRFLQATAAVTATGLMLPVPRLHAATATRETDHFWFRLAAEGPYIDSQREHRAFGFGDGKIYLSEDNARTWAYSADFPDAENITFSCLLKNGNVLFATREKLFLSTDNLATHRQIIVKDRAGRDYLPHTPRNPDLPGWYFHSLDGIHTWDIDGSEMLVWGNYCNVLGGPVPVNIYYSTDSGQTVKIAYAFGRNPHFQEKGAEPGLFLGDPTNPVICRHLHAVAYNPVERAFYACTGDVNRGHGNECHWLRGVYDARSDTWDWRVVVSVNSNSRYKSGGINFVDGQLYWAADANGRKSPEESYDRGIFRCAPADLADPKKHTRLFAAEFEMANMVIEDGVILAGHCAPASTYKTGIAISLDMGKTWAEYDLAEFGARSPVRFHPKNSDGWFRVDLRKGWIERAEVLLIKPKR
>NZ_CP036274|8219694:8277082|8251318_8251819_-|WP_145088085.1|DBSCAN-SWA
MSKLKLLGIVGVISTALAMLAWGQPKPAVPTHSEDALAGLMRAKLASSQKVVEGLMASDFDLIRKGAEEMAKVCDATNWHATDDQVYSHYRAELRRTAKKLILLAEEKNLDGSSYTYMNSLTTCISCHEHCRHVLHISEKGPDLRVIPIPTTELENSSDRTRPYRR
>NZ_CP036274|8219694:8277082|8252973_8254425_-|WP_145098466.1|DBSCAN-SWA
MHPLHQYQLNLTRRHFFQTGSHALGTAALATLAGQSAAAAPNENKLAGLQHFAGKAKHVIYLHMVGGPPQMDLFDYKPVMNDWYDKDLPESIRKGQRLTTMTSGQARFPISPSKFKFAQHGAGGAWLCELLPWKAKMANDLCFIRTMNTEAINHEPAITYIQTGNQVTGRPCLGAWSSYGLGSANENLPTFVVMVAKPSNTEQVQAISARLWQSGYLPGEHAGVSFRSAGDPILYINNPPGVPSAIRRKTLDGLNALNELNFNELGDPETQTRIRQYEMAYRMQSSVPDLTDFSKETQETLDLYGPDVKKPASFANTALLARRLVERGVRFVQVYHNNWDTHANVAGRLPDQCRDVDQPCYALVQDLKRIGLLDDTLIIWGGEFGRTIYSQGGLSKTNYGRDHHPRCFTIWMAGGGIKGGVVHGETDDFSYNITKDPVHLRDWHATILHLLGFDHQRFSVKSQGLDQKLTGVEEAHVIKQLLT
>NZ_CP036274|8219694:8277082|8246427_8246790_+|WP_145098445.1|DBSCAN-SWA
MKTTTSQEGPAGVGEETETWELRLYIAGQTPKSVAAFRNLKKLCEEHLPGRYQIEVIDLMQHPQLAAGDQIVAIPTLVRRLPEPLRRIVGDLSNTERTLVGLQLRLAKPLTTTEEGSDAR
>NZ_CP036274|8219694:8277082|8244664_8246431_+|WP_145098442.1|DBSCAN-SWA
MALATELQTPVMRGLAKAPTGIQGLDEITGGGLPRGRPTLVCGSAGCGKTLLAMEFLVRGATEFDEPGVFMCFEETTQELTQNLRSLGFDLDELVEQKKLAMDFVRVERNEIEETGEYDLEGLFVRLNYAIDAIGAKRVVLDTVEALFGGLSNVAVLRGELRRLFRWLKDKGVTAVITGERGDGTLTRHGLEEYVSDCVILLDHRVTDQMSTRRLRIIKYRGTTHETNEYPFLIDEDGISVLPVTSLGLLHKASTERISSGIPRLDAMLGGEGFYRGSTVLMSGTAGSGKSSIAAHFAAAACKREERCLYFAFEESPGQILRNMRSIGIDLEPWVEKGLLHFHASRAAIHGLEMHLSTIHKLVREFRPRVVIMDPVGSLTAVGTRQDASVMLTRLIDFLKMQGITALLTSLTSGEEALEQTDVNVSTLIDTWLLLRDLELDGERNRVMYVLKSRGMAHSNQLREFLLTDQGVELQNVYLGAEGVLTGSARQTREAIEKADSLLRHQEIEAKQRERVLKREALAARITALQKEFEAEEEVAKRDIEQENSREETHRQDRDRMGISRQGDKVLKDAEPAARSHETPRSRK
>NZ_CP036274|8219694:8277082|8225454_8225703_+|WP_145098400.1|DBSCAN-SWA
MTNRAPLIVAIVLLVLPPLLYVGSYLALVKPQGDIVWRKSRPFYCHYRVGSERVVPNLFWPLEQLDRKLRPTEWIGPAGKDD
>NZ_CP036274|8219694:8277082|8254448_8257604_-|WP_145098470.1|DBSCAN-SWA
MPRLTLAIVAPLVQFLSLAAAADGKIEFNRDIRPILVDNCFACHGADSAARKADLRLDQREAAIESTAIVPGKISESALIARIMSTDPKEIMPPPATKKSLKPAQQELLKQWIAEGAEYQKHWSFIAPVRPPLPEVKDKAWAKNPIDAFVLAKLESLGLKPALEADKRTIARRLSLDITGLPPDPAVVETYIKDESPNAYEKLIDKLLESPQWGEHRGRHWLDVARYADTHGIHFDNYREIWSYRDWVIKAFNENKRFDVFTVEQLAGDLLPNRTLDQQIASGFNRCNITTNEGGAIAEEYLVLYNRERTETVAQTWLGMTAGCAVCHDHKFDPLSQKEFYELAAFFNNTTQAAMDGNIPNTPPIMQVPKPEDQARYFTLDGEIAGATAAQAARKQQARGEFDRWLATAGSDTNSAAATIPTEKLYLSAALSEGQGRTTKIQVDGKDREVPLTEKGSWQPGNSGPALQTTGAALELADVANFERDQPFSTSAWIKLNPNDSAGAIAARMDNANKYRGWDFWVQARRVGTHIVNAWPDNALKVVAETQVPGNQWTHVAVTYDGSSKASGVKFYYDGKEQKTNVEADKLSATTKTRVPFKLGQRHTGEILAGVTVQDLRIYQKSLTAAEVESLAKTTRFAALLAKPADQRTPGENDELYNWWLGTNDKTFQEATANLNELQQEKANIIARGTKAYVMQEKESPAMAFVLQRGEYDRRKDQVKPNTPEVLPKMADDVPRNRLGLANWLLREDQPLTTRVTVNRFWQEVFGNGIVKTSGDLGVAGDLPANQPLLDWLAVDFRDGNWDVKRFFKQVFMSATYRQAAITTPEKLEKDRENRFLSRGPRYRMDAEMIRDYALSSSGILVQKLGGPSVKPYQPDGVWEAVAMIGSNTRDYKRDTGENLYRRSMYTFWKRSAPPASMEIFNAPNRESCATRRERTNTPLQALVTLNDPQFVEAARFLAQRTLKEGGADDAARLNFVTQHVLARSLRANELPVVLDSLKTIREHYSNSPDDTNKLITVGESKPDPFIKPAELATWTMIVNELLNLDEVLNK
>NZ_CP036274|8219694:8277082|8252190_8252619_+|WP_145098463.1|transposase|DBSCAN-SWA
MTSTTRTQRRYDHRLREIVCNSKNIDAAVGCGVPRSTARGWLAPRAMFESWWRVLKHQWLFLNRLDTLATVQKLVAFYVDQHNSHLPHAAFHGQTPDEMYFGTGADIPKQLAAAKVAARQARLAGNRAVRCQSCSAPVAISN
>NZ_CP036274|8219694:8277082|8239382_8239613_+|WP_145098430.1|DBSCAN-SWA
MDHAQKLHDLTGTVNSTRFFRWTAGARCCRGHAYLLDDLPAVPVTEKRRLRNVWLQMHWRGQHHEQDRNGHRALSA
>NZ_CP036274|8219694:8277082|8258495_8259998_+|WP_145098473.1|DBSCAN-SWA
MLQRSEKSSKVPLNHQPTIAILGAGAAGLCMGMRLKQLSIESFTIYEKSDRVGGTWRENTYPGAGCDVPSHLYSFSFEPKFDWSRVYSRQPEIQRYLEHCAQKYDLHRHVRFGFEVANASFDEAAGIWRLRTTSGEEFTAQVLITGTGQLNRPHTPEIPGLEEFGGAQFHSARWNHQHDLAGRNVAVIGNAASAIQFIPPVAEVAKKVHVFQRHANWIIPRNDRAYRTWERFAFQYAPGYARLMRALIYWKCESRFFVLFRKSWVAWYLKWCATRYLESHIQDPALRKTLTPDFTPGCKRTLISDDYYQALARPNVEVVTNGIARITRDGIITNDGTLHAADTLVFATGFEATRFLAPIEITGREGRQLADVWKHGAEAYLGVAVSGFPNLFLLYGPNTNLGHNSIIFMIECQVNYILQCLSRLQSQRLATLEVKPEVQDSYNRELQRGLAKTAWYAGCSSWYKTKAGKVTNNWSGFASQYWWRMRRPDPNAFHAAPEVT
>NZ_CP036274|8219694:8277082|8261143_8264341_-|WP_145098476.1|DBSCAN-SWA
MAVALETVVKQLEDSGIVAQGKLENFIPPKAAPKDAHELVAQLVKEHHLTKFQAAQVAAGKSKSLILGEYTILDRIGAGGMGQVLKALHRRMDRTVAIKMLPSATMKDAAAIARFEREVRAAAKLSHPNIVAAHDAGQANGVHFLVMEYVEGQDLSALVKKNGAFPVAKATNYILQAARGLEFAHGEGVVHRDIKPANLLLDKKGVVKILDMGLARIESDGETATQAELTGTGAVMGTVDYMAPEQAMSTKSADARADIYSLGCSLFYLLTGKPTFEGETITAKLVAHQAHPIPELRKACSEASAELESVFSKMLAKKLEDRYQSMSEVIADLERLGGRSQTSLGTSQAASTNCENSALTFLKDMPIQQTLHKSKATKKIAAAKSNDGKQPPWKNTKVLIGAAFLGVLVLAGIIVSLQTKDGTLIVEVDQPDAMVQVLDSEGKVEVSQKGVAGKVTISVDPGKHRLRVEKNGFVVFGQEFEMESGGKKAITAKLVSVKMQSTTNEVALDFDGKSSFVYTPLVYKNDGPLTVEAFVVARNRKVGTVISNASDTGFSLEIVKSKWAASSLTKSQTTTQVSLAEVEGEKSHLAAVFDGTSIRLFKDGVLQGASVADQEFVSRPYQIVIGADPTGKKGPQLPVSPSAVFDGIIDEVRISKVARYTGDFKPDPRFTPDADTIALYHFDEGSGDTAFDSSDNKHHAKIVGAKWVKADSSNLGAVATASTSKSPAVSFLTATSPVPPLAKAPFDAAQAKQHQQAWAKHLGTEVETTNSVGMKMVLIPPGEFMMGSTDEQVAAALKAAEETKADQGTKDRIEKAERPQHQVVITKPFLMGATEVTVGQFKNFSASGYVTAAEQEELKAKASPPPVVPGQPAKPIQTYLKPGYVVADDSPAAVITWNDAVAYCNWLSVQEKLDPCYVLNGNTSQLQPNKNGYRLPTEAEWEYACRAGTTTQYSFGDDHQQLEQYGWYNKNHGGRTHAVGTKLPNPFGLSDMHGNVWEWCQDYYDEKWHEKTLANDPNGPFSGSDRVLRGGHWNYYASYCRSAYRGNNSPSHRNNVSGFRVVRVW
>NZ_CP036274|8219694:8277082|8225781_8226288_+|WP_145098403.1|transposase|DBSCAN-SWA
MCSRSRELAGSRMEPTELGYRPQLNDEQWALIADFFVEPDPDPRGGRPRAAARHCLEGILWVLKSGSRWKDLPSCFPSYATCWRRFAAWSVDGIWEAAWRRLVLALDQRGDIEWEEGFADGTFASAKKGAILSAPPNAAREPSSCCWSMATACHWESTSTVPVLRKSA
>NZ_CP036274|8219694:8277082|8275672_8277082_+|WP_145083689.1|transposase|DBSCAN-SWA
MSHQDPSRSQQGRSQVVVAEFQADQLKQSLERLLGEGDWGAIRFRDDCTWGPRQLAATALLWAWSDELTLGDRFFAARRLAQFLFAPQQEFASSVQAFMKLLLRWTVLLVGVLQVTFRRQMQRALPTLWRVHGLVLFGIDGSRVDVPRSKSHEAAHAPVRDGKGRKLKRNRRQKPRTAIHSRKASVPQMWLTLLFHVGTGLPWSWRIGPTGSSEREHWLAMLDELPSNALITADAGFVGYDCLRAVVNSGRHFLVRVGSNVRLLYKLGFSREVVGTVYLWPDRAARRSQPPLVLRLVVATGGKYPVYLLTSVGEEELSRGQVLDVYRRRWGVELFFRHLKQTYQRRKLRSTNAAHARLELEWSLLGLWSMALDAQVQATRVQLDPTQLSLAGVWRTYRRLMRDYRHPLARQQSLPHQLPQAVRDTYERANKSSRNYPRKKRPDPPAGSPEFLLATKSQIHRARYLTTAA
>NZ_CP036274|8219694:8277082|8226212_8226611_+|WP_145098406.1|transposase|DBSCAN-SWA
MLLVDGNGLPLGVDVNSASPAEVGLIEPLLEEAVTDYVPDRLIYDRAADSDPLREHLADRGVELICPHRRGRVRPPTQDGRALRRYRRRWIIERTISWLHSFRRLVTRYEYYSFLFHSFAKLACMMIVLRRF
>NZ_CP036274|8219694:8277082|8226768_8227035_+|WP_145098408.1|DBSCAN-SWA
MLTALLRSIGVTEMPGCNCGARADRMDRWGVEGCWGNIETIYSWMEESQAAFGWLEKARAAAAAFSTGLAFGLDPARPLTSLVDLAIE
>NZ_CP036274|8219694:8277082|8239709_8239955_-|WP_145098433.1|DBSCAN-SWA
MSITGILPVVLGTDDKKADVAEHPGVVHYVGLLISQRCIVLLKSGVTQAEDATWFIPPIICTRKPVLHVRLDGEDPVADPA
>NZ_CP036274|8219694:8277082|8221406_8222126_+|WP_145098391.1|DBSCAN-SWA
MATVEGHLALAETQLALDGFAEAETSAAAAFRLDGNSAKAQAIMGLAKLGQMRNKIALGHLDVNDPISKAVRSDPQLTGWILNEMNRIKPGYRIAGLGNSEQMGRIEDQVAAANAIGKEAVALAQKGDFKAAADTMLRCADAYPNVTPGIPCMIRQQAAQLRFQSGDNQTALADADRTIQLFPDLPPGYVARYIALKLLNRDAEAVAAKQKLVEMKAPEAERLETALQAIQAMQSKAKP
>NZ_CP036274|8219694:8277082|8247146_8248844_+|WP_145098451.1|DBSCAN-SWA
MADVKQSELAELQLRLEEAEETIRAIRSGSVDAFVVEVPNGARVYTLESADRPYRLLVEEMQQGAITLSLDGTIAYCNRRFADLVGKPLERLLGVAFHEFIPFAARTFYESLLQQGRAGSSEGETHVQKFNGTLVPVFLTINALPPESGVAIGLLVTDLTSQHHHEKLNSLLGELKESDRRKNEFLAMLAHELRNPLAPIRNAVQLLRLTKGGDGATIHSIAEMMERQLGQMARLIDDLLDISRISRGTIELRRARIELTSAVQHAVDAARTLVDEKVHTLTLTLPSQPVYLNADPTRFAQVVGNLLSNACKFTDKGGQIWLTVAVDEVGDAKSGAHPSSESSLLPAMATIRVRDSGLGIAADQLIRIFEMFVQVDTSLGRPVSGLGIGLALVKSLVEMHGGSAEVNSAGIGQGSEFVVRIPILVERLTPLLPPADQPTAINSHRILVVDDNRDSARSLAMLLKFLGNKTQMAFDGLEAVEVAATFLPEIVLLDIGMPRLNGYDACRKIRDQPWGKSMVLVALTGWGEDEARQKSKDAGFDGHIVKPVDHAILAKLLAELLPIPA
>NZ_CP036274|8219694:8277082|8219694_8221209_-|WP_145086469.1|transposase|DBSCAN-SWA
MLRDMHNWTEIRRLVLTEKKSKRAVCREFSLHWQTLEKILQHPEPPGYRQRLPRERPKLDPFLPIIHEILEQDKTAPRKQRHTTKRIFDRLRAEHGYTGGITVVGEVVREWRTTTAEVFLPLSHQPGEAQFDFGEAEVVLQGMPTKVAYCVMSLPYSDAFFVQVFPRECTETFQAGHQRAFEFFGGVPRRISYDNSRIAVARFVGKRGDTPTREFLRLQSHYLFEHHFCLVRRPMEKGHTENLIGFARRNFLVPVPRTGSLEVLNAELERQCCEDLERQLRGQPANKATLLAEEQAALLPLPKSGFEARRVEPAQANSLSLVRFDGNDYSVPTQYAHQKVTAIGGLEEVRLVVNDKLVAQHPRDWSKEQVHYNPLHYLALLERKPGGLDFAKPLENWGLPDCFDLLRRRLEADGGAHGRREFIKTLRLLETISLAALTAAIERALEIDVLAVDAIRLLVQQGLEEPTRWFRLDNHPHLQSHSIPPPNLLSYRELTCALTTGGVL
>NZ_CP036274|8219694:8277082|8227876_8233687_+|WP_145098415.1|DBSCAN-SWA
MSPESNDMNPESCLTDELLKRLYEGLLSEAELNVVVPHLESCAICERRLANVSVGGGEVAQFVRQDAEGQLPEVVEDLMRALRSRRSPSLKQDLPAHFNCPHCHNPIELVADEDLNEVVCPSCGSSLQLDHSETKTWNPTQLPMLGRFQLIERVGQGAFGTVYRAYDKELDRTVAVKVPRSGRLATPEDEDRFVREARSAAKLRHPGIVAVYSVERSDRFPYLVTEFVQGVTLADALTGRRFTHREAARLIVQIARSLEHAHDQGIIHRDLKPSNIMLGDDSGPRVMDFGLAKRSADEITITLEGQVLGTPAYMSPEQAVGSGHRADNRSDVYSLGVILYELLTGELPFRGNVRMLLHQVVHDEAPSPRKLDHRIPRDLETISLKCLSKDPAKRVASCGELAAELERWLRGEPILARPIGRLSRFVSWSRRHPDIAGLLATVLTVLLIGISVSTFFWIRSAQNAVVAEANALQAKANELKSNLNAKIADEHRHAAETNAKRASANAERAEEQSRFAKQKEEDARWSAYVSAMNLGFQAWQDGYVGRAQQLLEEQIPQPGQRDLRSLEWLLLWQQCHEQSFALRGHQKRVNCVAYSPSGETLASASDDGSVILWNTSDRTIRNRIHQPNAKVKALSFSPNGKWFATAADNGNVIIWNATSLNKEREFLTGLTTLDVVNSIPLTLVISDDGKLLVVGGEASIRVWETRSWSEVFRRNIGHSAIAISPDSEVLAISDHSGQTRLLAISDGRELASHGIYTFALGFSRDGAFLHSAVTNGSGLYKYDRKLGQIAQSVSKEAAPTKDLAISKSGEIGILVGGDGSASGTIDVWDLKTYSWIRRLSGHDGSVCSVAFAPDDRKFATGGADGTVRVWDNESLLQNGRSQGHREYVLACCFSPDGSLVATGGVDKTVRVWDSRTGELLQLLPQPERVFGIAHSPTEKLLAIASASQAGDGLRICSTSDYQQESVAVNGLEPLSVSFSPDGERIACGMRSGEVLLLDSTDRTVLNSCKYHLGPVYSVAFSADGTLLATGTGDNHCAVITSDTLELRYFLRGHTNAIRQVAFSRDMQLLCTASLDGSVKVWDLHSGTLKATLAKSPLSAFSDSYAVAFTPDGKSIVGAYSNDQYDGELRLFQVSDLTQHGKFAVPLALVSSMALSCDGKQALLGLNDGRVSIIRLDDPTATKTLGVRSDCYGSDFSPDGSKFAVGGYQHVSVFDTSTRKQLFTKRVGTQNITGVRFVENGRRLLTSESEPAHGPRSPGELCVWDAATGAKVTTCLIDSQSGLISLAPDERELALVGVASQTGAPNIIFLPGISTVQKNARIVLPKGVGGAGFENIMFSPDGKLLLLAEGSYFDSEPGTVIIVDRKTSSVIGSLRGHATSVTSIAFLDNGSTVVTGGTDRTLRVWSMKTGQLLRTVNTREAVLAIATSPNSSRLITSHSDRVCRIWETVTWNEICSFRAPSGLYGSINVSPDETSLLVTGSNRTSIRPDYEVLRIAKPADVETYRVREVEFHEEVRRASVQRREDAESLLTRLKTAHEDGLIGESSLFLGHRLFSVDSDVLDVSEHEARALFTSAFEGALAWDKLPIQLSKIEPIKLRKSREQGAANAKRKKEGLEYMAGLLQDAKQNDSQATQNSALSSLERVLIFDPANVEAQQMTAKIRASAPAASITNTLGMTLIKLESGRFWMGSLNNEEGRRPDEVIHPVRFTKSLFLAAHEVTRGQFAEFIEKSGYVTEAESAASDATRDVLTWRSPGFEQDDRHPVVSVSWHDATAFCEWLSKAENKKYRLPSEAEWEYACRAYSTTPFHWGDRLDQGEGWGNLAGRDDDDLTKPSARVPWSDKRVFTAPVGTFKANAWGFYDLVGNVSEWCRDDYQSYPVLLVTDPKSDRFGSLPVVRGSSFSSEPTTSRSAFRHRLPAKRVSTSTGFRVVLESDDEK
>NZ_CP036274|8219694:8277082|8237817_8238420_+|WP_145098424.1|transposase|DBSCAN-SWA
MEVALDVHLHLSLEELVRRERVEKDAAQSKRLRIVILAIGGWTAPAIAMSVGLSRRVCQRWVYRFNEFGLAGLDDRRGAEPKPTLTPEQQVQVCERLEAGATLADEVCSLRGVDVQRILAEEFGVLRSLAAVYHLLHRLGYSYLTPRPRHRRSNPAAQEQFKRELPARLQALRTEHVGKSVRVYFQDESRFGQHGTTTNV
>NZ_CP036274|8219694:8277082|8237377_8237731_-|WP_145098421.1|DBSCAN-SWA
MTNVFRSLLLVIAGSTQKELARQIKYLKVENQILRSKLPKRITVTLKERNRLVKFAQKLGGKVLRQLTTIVAPSTILGWIRAEKKQKPKKRKRGRPNTPEQIRDLILLTAKENLHQG
>NZ_CP036274|8219694:8277082|8269226_8270798_-|WP_145098484.1|DBSCAN-SWA
MKLGTFTLVFGLACLTALASAQAQSKKPNILVIWGDDIGTWNISHNNRGMMGYKTPHIDRLAKEGVAFTDYYGQQSCTAGRAAFISGSVPVRSGMTKVGMPNAPQGWQKTDCTMATVLKSQGYATGQFGKNHQGDRDEHLPTMHGFDEFLGSLYHLNAEEEPEQRDYPRDMKLANGKTFLEQFGPRGVIKSKADGKGGQTIENLGPLTKKRMETIDDESMAAAKNFITRQAKAGQPFFCWWNGTRMHFRTHVKPEHIGISGQDEYGDGMVEHDMHVGELLELIDELGLADNTIVQYSTDNGPHYNTWPDAGTTPFHGEKNSNWEGAFRVPCLIKWPGHFPPGVTLNGIVSHEDWFPTFAAAAGNPNIKEQLLKGADLNGRHYKNHVDGYNLTDYLSGKVKKSPRNEFFYVGDDGDMMAIRVGDWKATYLENRARQLQVWREPLVKLRMPLLFNLRRDPFEKAYENSNTYHDWMIDRAYVLGPMQMVASKFLMTMKEFPPSQMPGDWSLESLEKQIKGMTAGGK
>NZ_CP036274|8219694:8277082|8234023_8237206_+|WP_145098418.1|DBSCAN-SWA
MPRHKHRSSKTFRRLGNGVELLERREVMASAISAALTQSVLVIEGTPGNDSIRVRQMNGQISVEGVAGSWSAGQVTAIRVAALDGNDLVDLSSGLSGQQKLNVPAYVDGGLGDDSVVGTNAKDELVGGGGNDWLLGGLGSDILRGGAGTDRLFGQNADDTLLEGEMSAQVISTGISADGKIYVLRDDGVVERVGFGAIGTGIKSLGVAPDGVVYGLMQNQIVYRYAIGTNSWSSISGAEVTSLSVAANGAVYCLTSSKIVYRYTGMNNRWDAISGAEVTSLQVAADNNVYCLTTGKIVYRYSGTGNSWTAITGAEVTSFSIAANGTVYCLTAGKVVYRYSGSGNAWSAISGAEVISLSTTPDGGVFCLTQGKLVYRYNGAGNSWTPISGAEVITLTTTADGSLYCLTTGKIVYRYTGNSNIWNAISGAEVTSLGVSPDGGLYCLTVSKVAYRYTGISNAWNSLPLATTDGGRLTIRGSEGNDTITVSPLSAGRILVSGIAGSLSGEWSTAGITSIQIEGLGGDDTIVNQGGTVPVVAHGGVGNDRLAGSHALDALYGDEGSDLIEGSSGVDGIYVSNNVLYVIGTPGDDTLEFHRNNGRVIIRGHRPDLGLHTDLTRNWPTPTRVEVLGLNGNDTITNVSVLSPVIIKGGDGNDFLRGLNPTDGLYGEEGNDTLDGSAAFDILASNDGVLFAAGTPGNDILTVAQNDGYILLRGAGKEVTRKWAYKPLPGVTEVYRVEVSGLGGNDTITSIATEFGITARGGAGNDRLTGGDGDDRLAGGVGNDLLIGRLGNDTYVFEDEATPFEVDTIVELVGIANGIDTLEFSDVSRDLFVSLRVNGTISTESLRIINGIGGAFERVIGGSGNDVLHGSEQPDFLYGGDGNDTIYGYDSDDILLGGFGSDCLYGGQHNDVIDGGFGYDIICDTEGANLFFADLVIQAAQIRNGTAIVTTSADTVITGSSDTAKNVIVARSESAVGTSFEGGSPKVGPSDGAIVVTKTLKYVTAGTVIGGIIGGVIGTIAWGPGPGTAAGVLAGAKWGAFTGAAIGIGEGICDLIASIF
>NZ_CP036274|8219694:8277082|8246779_8247136_+|WP_145098448.1|DBSCAN-SWA
MPAELTPKEIDSSAAFEKLVAGPPADARYVLRLYVTGMTARSTEAFAAIKAICEERLQGRYELEVVDIYQHPQLAIDEQIIAVPTLVKMLPAPLRRMIGDLSNVDRVLLGLDLRRKPE
>NZ_CP036274|8219694:8277082|8249148_8249544_+|WP_145098454.1|DBSCAN-SWA
MSDTFESHTPLRILVVEDNKDAADSLAMLLRIQCAHSVDVAYTGLQALQIANIRRPDVILLDLGLPIMNGYQVAEAVRAMPDAEEIVIIAITGHSQPEAVDASAAAGIDLHLAKPVDIRRLLSYLSGRGLS
>NZ_CP036274|8219694:8277082|8227287_8227845_+|WP_145098412.1|DBSCAN-SWA
MHSTSFTLLERVKVARNDADWDRFVNLYTPMLFAWAKRFGLGDADACDLAQDVLLILLKELPNFERGRKFSFRSWLRTIATNKCREHLRRKKPQALDPMSALQLSDFDAEPFWEHEYRQLLVARALTVMKAEFEATTWQACWEHVVSGRKAADIGAELRLSEGAVYAAKCRVMKRLREELEGLLE
>NZ_CP036274|8219694:8277082|8224114_8224321_-|WP_145098397.1|DBSCAN-SWA
MRHHAGLAGFISDTTWLRWASGTLYFGDVMDMKPWNDDVPPDTKIASNIKTREDLEAIILKMAPQNSA
>NZ_CP036274|8219694:8277082|8272974_8274051_-|WP_145098490.1|DBSCAN-SWA
MEKKPKSISPSTSVSVPQHELRNIFALKDHPDQKHFFPPENGADLEKLCDQILANGLTEVVEITSDGTVISGHRRLSALRRLVIDRNLPQWETIEVKVRYDLDSQGDAAIKVRLIEANLNRRHLPPLEELGLTIEAQRGRGEEVEKDKLLKEVGERRNVKRVTMERYWDLMALPLELRRLVDRKKLSQQVGQAILDHATEAETEELRQLAISGGNVKKRARELLEARLPEKQRQPPTPEEALDRFLVASLDVAVYFKPIKRFIEENIGDRLKVFTWFRRSKDAELVVPLLMSLISRSPRLDAEDREYRPTLGKQSLTDVIAKVAAAHKAARNAEIEEPASLRPAKKLPPLILPKNPAA
>NZ_CP036274|8219694:8277082|8238447_8238882_+|WP_145098427.1|DBSCAN-SWA
MRQTEYKYLWVLGAVCPETGHSDGLLSPHLNTKIVNIFLQQFSQTLTANEHAALIWDGAGFHTSSELNVPANVTIIQLPAYSPELNPIENLWHYLKSHYWSNRAYADYADLETSAIKAWQLAVLDPDLMKTVCAAPYADGATLK
>NZ_CP036274|8219694:8277082|8223143_8223794_+|WP_145098394.1|DBSCAN-SWA
MFRFLLTVVVLWLAIPLAAFAQTGDAAPKKPEARMPIGRTHGMSGGTLQSNHEKSDGTRVLHGLQVVYGPRLQIKEYSVFNLGRCEQLVQIHPNGNSFRMQWREHNGDGHEALYASGADTMIAEKVIVDGGKDIGPIKVPERICLGWVRAGKCYSGTFLMREVQGFQFVLRLHEYKEGKLVNSKPFPFERFGIPVAEATEEKWRWSFPEWPQAGKE
>NZ_CP036274|8219694:8277082|8250633_8250897_+|WP_145098460.1|DBSCAN-SWA
MAKQVAVFTLIDNNLADPVVGNFAGQLGGSLVNVNGFNKQISYIRAATETTSKSRSRCLKLLSVFRKRELLFEEGWAQGESTRSKSW
>NZ_CP036274|8219694:8277082|8239944_8240346_+|WP_145098436.1|DBSCAN-SWA
MIDTNILLVDDDSDTCDSMSDVFLDLGYTVDTAHDGASALELSGGHHYRLALLDYNMPDMDGLELCRRLKNMQPNIVVALITGFTSITTTGEAAEAGIRCSFLKPINFSLLMPLVEKIVGNFVFRRLGSDVPT
>NZ_CP036274|8219694:8277082|8240727_8243274_+|WP_145098439.1|DBSCAN-SWA
MGELIMTIDRICLRSIALFIAGFLPPPGLAADWPQFMRNSEHTGDAAEEALQLPLGLATCVRLDDAITTSPAVVNGTVFVVDQMGTAYAIDPIESKILWQSSPDGNRAMGGNTSSVCVARGRVYYGTTAGRLHVLDAKDGRLIKSFDVGWPILGAAVFANDSIYLQSVGAIVHCFDLNGTERWRWDHYKSYQDPKTNKLASGFPGSFHDPHYAGGEVAVAGNRVVVNMGWDLYCLKDQGEKPEMVWCNRAPLGKDPGIAMGPAINGEWVYVGHPGTDQFGGFMRVRLADGGFDPKVDFRSSGYPGSVWAVFATPAVREGTAYVPTHYMGVHAWNFDKHQALWAARTDNTLDQSKFTSCISSPALTRGHCVFGTITGELHVIAVESTGGWPQFRPTPFTFKTPLGRPIGSSPIACGGAVYFGCDDGYLYGLKAGGKLQLPQPRNDLHAVRSRAVPATGSSYGAPVASMDQANTGCVDDPRLKPPLRLRWATRPFDLRVQMSADEDSLYFISEAGTFAALEQATGRIRWRQRLNSPIGGWQQLLLDRGQLFVTRSTSALRARKPEEGGSAFNAFDAKTGQLLWQAEWGSLQGTCRTSPVIVGDVVAGITLEGSPPKPRARAFHAETGAALWSLDLPGNAKLMAGGTCVLDGKMIFSCGQTWGAGLGATVVVEPGTGKVLWETTEHHIHGYGRPAGRDGLIYLGGQSGAPMVCLSVFDGSLKWKVDMVSYSHSPSLGQDFFVTRSYGGHGILRELASGKPIIRNGREALGGCPDHSCSPVLLTTGRISYAVSSSGLYARNVDSGEIIWQSLGFAPRACTTPIAANGRLFFSPNVNNSIYCFEPLGVQRDQP
>NZ_CP036274|8219694:8277082|8264488_8268748_-|WP_145098479.1|DBSCAN-SWA
MPQTADQFAKALIAAGLSSADEIKSLWSSLPAGSRPKDGETFAKVLIEREKLTKFQAEELLSGSQTPLVLGDYVLLAKIGAGGMGQVFKAHHRRMKRLAAIKLLPTSLTKDEAAIKRFEREVEAAAKLTHPNIVQTYDAGVQRGVWYLVMEYVEGRDLSGVVAHEGPLPVARAIDYIRQSAKGLAFAHENGVVHRDIKPANLLLDKKGTIKILDMGLARFEDGVAAQEGLTKSGDVMGTVDYMAPEQAFDTRHADARADTYSLGCTLYRLLTGQNMYDGETMVQKLMGHQSKPIPSLATQRPDTPKALVTIFERMVAKKPADRYQTMAEVEAALALLASPPPAASSSAKPEADSKLGSFLQSFMGKKPMPVTGGVATAQRPRTAAKTMDELSPTIAVASAQVTTEPISDRSIQVAGSRPPQRPQGPWWRQPLVVMAGGLGGFLLLALGVWVIIRDKDGKEVARIEVPDGGSATIQTKGNDLPPSTPVGKPPPLAKAPFDAAQAKAHQAAWAQYLGTEIETTNSVGAKMVLIPPGEFMMGSTDEQVEAALKAADEIKADGGVISRIEKAERPQHKVVITKPLLMSATEVTIGQFKKFSATGYQTEAEKAEAAANAASPPPVEAGQPSPKPTPNYLNHRPDLTDDSPAAYITWNDATAYCQWLSTQEKRTYRLPTEAEWEYACRAGTTMQYSFGDDYNELPKYGWHNKNAGGKSHPVGTLLPNPFGLFDMHGNQYEWCGDYFDEKWYAASPLNDPNGPSAGSNRVIRGGNWNFPASHCRSAYRTNNTPSPRPGFRCVSVLDAPATTANGPPSTPPVVTPAPAIKTAGATPPLAKAPFDAAQAKAHQQAWAKHLGTQIETVNSVGAKMVLIPPGEFQMGSTDEQVEAALKVADKFNAVQFHKDWIQKDERPRHRVVITRPYWIGATEVTVGEFKKFSATGFLTDAEQRAGAASKTIQSPGQTPTDAGSPILTYLNPGYSVTDDSPAAAISSYEALAYCKWLSDEEKTQYRLPTEAEWEYACRAGTTTQYSFGDDHAELENYAWYNQNAKTNPRPVGMKLPNAFGLFDTHGNLVEWCQDFYDEKSYEKLTLENPVGPLTGRLRVLRGGAWNSIPPTTRSAFRNHEPATNQIGTAGFRIVRVFNAPSTTASVTPQPAVPAAASAKLFMHDPAFPQWMKDVQAMSAEQQIEAVSKKLVELNPGFDGAMGADAGPSAVKGKPKVENGVVTQVALVSSQLLDISPLRAFAGLKKLSCHVPQGPANGILRDISPLTGMQLTSLSIRGQKFLSDLTPLKSMPLNDLDCSGCKSVSDLTPLQDMALTTLNLRETPIVDLSPLRGINLKNLDLFDCRQLVDLSPLKEMKLESFAIGSFGAMKVSDLSVLAGMPLKDIQLNYNPERDKELLRSIKTLERINFKPSTEFLEKN

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_145086469.1|8219694_8221209_-|transposase	IS21 family transposase	NA	NA	NA	NA
WP_145098391.1|8221406_8222126_+	hypothetical protein	NA	NA	NA	NA
WP_145098394.1|8223143_8223794_+	hypothetical protein	NA	NA	NA	NA
WP_145098397.1|8224114_8224321_-	hypothetical protein	NA	NA	NA	NA
WP_145098400.1|8225454_8225703_+	hypothetical protein	NA	NA	NA	NA
WP_145098403.1|8225781_8226288_+|transposase	transposase	A0A0N9SHJ4	Paenibacillus_phage	3.7e-09	35.5
WP_145098406.1|8226212_8226611_+|transposase	transposase	NA	NA	NA	NA
WP_145098408.1|8226768_8227035_+	hypothetical protein	NA	NA	NA	NA
WP_145098412.1|8227287_8227845_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_145098415.1|8227876_8233687_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A075BSL8	Microcystis_phage	1.7e-28	34.0
WP_145098418.1|8234023_8237206_+	hypothetical protein	NA	NA	NA	NA
WP_145098421.1|8237377_8237731_-	hypothetical protein	NA	NA	NA	NA
WP_145098424.1|8237817_8238420_+|transposase	IS630 family transposase	NA	NA	NA	NA
WP_145098427.1|8238447_8238882_+	hypothetical protein	NA	NA	NA	NA
WP_145098430.1|8239382_8239613_+	hypothetical protein	NA	NA	NA	NA
WP_145098433.1|8239709_8239955_-	hypothetical protein	NA	NA	NA	NA
WP_145098436.1|8239944_8240346_+	response regulator	NA	NA	NA	NA
WP_145098439.1|8240727_8243274_+	PQQ-binding-like beta-propeller repeat protein	NA	NA	NA	NA
WP_145098442.1|8244664_8246431_+	circadian clock protein KaiC	NA	NA	NA	NA
WP_145098445.1|8246427_8246790_+	circadian clock protein KaiB	NA	NA	NA	NA
WP_145098448.1|8246779_8247136_+	hypothetical protein	NA	NA	NA	NA
WP_145098451.1|8247146_8248844_+	response regulator	W8CYF6	Bacillus_phage	7.5e-22	27.9
WP_145098454.1|8249148_8249544_+	response regulator	NA	NA	NA	NA
WP_145098457.1|8249606_8250605_-	DUF2332 family protein	NA	NA	NA	NA
WP_145098460.1|8250633_8250897_+	hypothetical protein	NA	NA	NA	NA
WP_145088085.1|8251318_8251819_-	hypothetical protein	NA	NA	NA	NA
WP_145098463.1|8252190_8252619_+|transposase	transposase	NA	NA	NA	NA
WP_145098466.1|8252973_8254425_-	DUF1501 domain-containing protein	NA	NA	NA	NA
WP_145098470.1|8254448_8257604_-	DUF1553 domain-containing protein	NA	NA	NA	NA
WP_145098473.1|8258495_8259998_+	NAD(P)-binding protein	NA	NA	NA	NA
WP_145098476.1|8261143_8264341_-	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A7F1	Microcystis_virus	8.2e-30	43.1
WP_145098479.1|8264488_8268748_-	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A7F1	Microcystis_virus	1.8e-32	44.8
WP_145098484.1|8269226_8270798_-	sulfatase-like hydrolase/transferase	A0A2P0VMN7	Tetraselmis_virus	1.9e-141	50.1
WP_145098487.1|8271230_8272502_+	hypothetical protein	NA	NA	NA	NA
WP_145098490.1|8272974_8274051_-	hypothetical protein	NA	NA	NA	NA
WP_145098493.1|8275020_8275533_-	DUF4976 domain-containing protein	NA	NA	NA	NA
WP_145083689.1|8275672_8277082_+|transposase	transposase	NA	NA	NA	NA