CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP036352	Phycisphaerae bacterium RAS2 chromosome, complete genome	7 crisprs	DinG,csa3,WYL,PD-DExK,cas3	0	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP036352_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036352_1

210366-210527

Orphan

Consensus_repeat	Method
CATTCTGTCGCACCTTCGGTGCT	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP036352_1

>merge|NZ_CP036352|1|210366-210527|CRISPRCasFinder
CATTCTGTCGCACCTTCGGTGCTTCGAACGTTGGGAGAACGTTCACTACCCACGGGCTGACGCCCGCGGCTACATTCTGTCGCACCTTTGGTGCTCCAGACCTGAAAGTAGTTGCGCTCGTCAGGTTTGCCCGGGGCTACATTCGATCGCACCTTTGGTGCT

>NZ_CP036352|1|1|210366-210527|CRISPRCasFinder
CATTCTGTCGCACCTTCGGTGCT	TCGAACGTTGGGAGAACGTTCACTACCCACGGGCTGACGCCCGCGGCTA
CATTCTGTCGCACCTTTGGTGCT	CCAGACCTGAAAGTAGTTGCGCTCGTCAGGTTTGCCCGGGGCTA
CATTCGATCGCACCTTTGGTGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036352.1\|WP_145124540.1\|215007_216405_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223231
NZ_CP036352.1\|WP_145124541.1\|216464_216872_-\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NZ_CP036352.1\|WP_145124533.1\|207359_208442_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	unknown
NZ_CP036352.1\|WP_145129656.1\|220986_221397_+\|arsenate-reductase-ArsC	unknown	unknown	gnl\|CDD\|319973
NZ_CP036352.1\|WP_145124527.1\|198695_199439_+\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|367615
NZ_CP036352.1\|WP_145124538.1\|212922_213828_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
NZ_CP036352.1\|WP_145124535.1\|209275_210139_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124543.1\|221647_223054_-\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|234779
NZ_CP036352.1\|WP_145124539.1\|213904_214906_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124529.1\|201562_202885_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341239
NZ_CP036352.1\|WP_145124536.1\|210795_212154_+\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223238
NZ_CP036352.1\|WP_145124531.1\|205274_206870_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|379140
NZ_CP036352.1\|WP_145129654.1\|212264_212567_+\|nucleotidyltransferase	unknown	unknown	gnl\|CDD\|224583
NZ_CP036352.1\|WP_145124526.1\|197959_198688_+\|superoxide-dismutase	unknown	unknown	gnl\|CDD\|223678
NZ_CP036352.1\|WP_145124537.1\|212553_212889_+\|DUF86-domain-containing-protein	unknown	unknown	gnl\|CDD\|225236
NZ_CP036352.1\|WP_145124534.1\|208620_209241_+\|nucleotidyltransferase-family-protein	unknown	unknown	gnl\|CDD\|379721
NZ_CP036352.1\|WP_145124542.1\|217128_220668_-\|class-I-tRNA-ligase-family-protein	unknown	unknown	gnl\|CDD\|235582
NZ_CP036352.1\|WP_145124528.1\|199326_201432_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP036352.1\|WP_145124530.1\|202881_205254_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|379140
NZ_CP036352.1\|WP_145124532.1\|206950_207301_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP036352.1\|WP_145124540.1\|215007_216405_-\|hypothetical-protein	gnl\|CDD\|223231	COG0153, GalK, Galactokinase [Carbohydrate transport and metabolism].	6.17849e-16
NZ_CP036352.1\|WP_145124541.1\|216464_216872_-\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	2.48175e-41
NZ_CP036352.1\|WP_145129656.1\|220986_221397_+\|arsenate-reductase-ArsC	gnl\|CDD\|319973	cd16345, LMWP_ArsC, Arsenate reductase of the LMWP family. Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).	7.95869e-69
NZ_CP036352.1\|WP_145124527.1\|198695_199439_+\|PH-domain-containing-protein	gnl\|CDD\|367615	pfam03703, bPH_2, Bacterial PH domain. Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.	1.80151e-11
NZ_CP036352.1\|WP_145124538.1\|212922_213828_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	4.61294e-17
NZ_CP036352.1\|WP_145124543.1\|221647_223054_-\|aspartate-ammonia-lyase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
NZ_CP036352.1\|WP_145124529.1\|201562_202885_+\|AMP-binding-protein	gnl\|CDD\|341239	cd05913, PaaK, Phenylacetate-CoA ligase (also known as PaaK). PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.	1.14566e-113
NZ_CP036352.1\|WP_145124536.1\|210795_212154_+\|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223238	COG0160, GabT, 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism].	3.6146e-159
NZ_CP036352.1\|WP_145124531.1\|205274_206870_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	3.5065e-17
NZ_CP036352.1\|WP_145124530.1\|202881_205254_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	3.11929e-21
NZ_CP036352.1\|WP_145124526.1\|197959_198688_+\|superoxide-dismutase	gnl\|CDD\|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	8.59592e-97
NZ_CP036352.1\|WP_145124537.1\|212553_212889_+\|DUF86-domain-containing-protein	gnl\|CDD\|225236	COG2361, COG2361, Uncharacterized conserved protein [Function unknown].	2.55069e-26
NZ_CP036352.1\|WP_145124528.1\|199326_201432_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.30641e-50
NZ_CP036352.1\|WP_145124542.1\|217128_220668_-\|class-I-tRNA-ligase-family-protein	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
NZ_CP036352.1\|WP_145124534.1\|208620_209241_+\|nucleotidyltransferase-family-protein	gnl\|CDD\|379721	pfam14907, NTP_transf_5, Uncharacterized nucleotidyltransferase. This family is likely to be an uncharacterized group of nucleotidyltransferases.	5.46936e-06
NZ_CP036352.1\|WP_145129654.1\|212264_212567_+\|nucleotidyltransferase	gnl\|CDD\|224583	COG1669, COG1669, Predicted nucleotidyltransferases [General function prediction only].	3.28324e-19

>NZ_CP036352.1|WP_145124535.1|209275_210139_-|hypothetical-protein
MRDASGRKNKEDYERDMAREYLEFKGIHFTRLQTLAEFRPAHASEGIDGPDIFVTLLHDDTHHMTGIELTRYICRKNDHGSASLRLNDINDKLNTYVRTVLIPKARDLRGFSISMTLNLENLPRGQEICDIADGVVKFIDERRIEMDELVIEDSYTRRLPSVPFDGFPVLARFLKSLRIMRTELNDLAWKVSDATAIGLDDDIIVATIVEKSEKLAKYHVDDCDETWLLIAADGSGSDCRIGPPMERDRILENGKIVGAAQRSGFDKVIIWERVREWDAVIRGQTQT
>NZ_CP036352.1|WP_145124534.1|208620_209241_+|nucleotidyltransferase-family-protein
MNAFEDTMARGGTAAVRNAASFFMKTDPVHRALQGITQRLRDLGVDYAVAGGMALVAHGYDRTTVDVDILVTPHGLKTIHDSLEGLGYVPPFAGSKQLRDTQTGVRIEFIVTGQFPGDGKPKPVAFPDPADASVEIDGIRYVNLPTLLELKLASGMTNSGRLRDLADVQELIRVLKLPRDYAEKLNPYVREKFVELAAGLWGDSAC
>NZ_CP036352.1|WP_145124533.1|207359_208442_+|long-chain-fatty-acid--CoA-ligase
MSQSLNDKVAAARKRLDEHTREIVAWHFDPASGCPFWIEYAKTLGWDPRKEVTCYADLDKFPPFQDEWLRGGPVRRWVPRALADQPVSLFETGGSTGVPKSRINISDYRTDYEMFSATLDDKAFPKGADWLMLGPTGPRRLRLAVEHLCQFRGGICFLLDMDPRWVVKVIKKGRMDVMDEYRNHVIDQALTLLKAHDNIRCLFATPKLLEALADRISLVKAGITGIFCGGTSMTPQFHKFAREELCEGKVEFVPTYGNTLMGLATCKPFDPADNYDIIYHPPLPRAMLEVVSFTDEKTPVAHGEWGRVRLTTLTKEFFVPRFLERDEAKRTPPCDLYPWDGTANVRPFSGFGTTVVEGVY
>NZ_CP036352.1|WP_145124532.1|206950_207301_-|hypothetical-protein
MAIRDRTRKRLIGAAILFVYIAFPVYSIIESNFMPTIIGGFLIVMGIPLFLVGLFYSLERVGFLPRPVPRTRCQQCEYLLTGNASGVCPECGASIPVEQQLAIRIDPVDDPNEPQL
>NZ_CP036352.1|WP_145124531.1|205274_206870_+|PQQ-binding-like-beta-propeller-repeat-protein
MSAVRRRLQAIEIATNRLRWSQIRSGGQSKRTGAVAKMIFHFNSIRSRTVAVAALAIGVCGLALSTHAEPLEKAKRGDWPMWGGSPDRNMVSGEKNIPAKWNIKDKTNIKWVAPLGSQTYGNPVIYKGKIFIGTNNTGEYRPKIKGDKGVVMCLDEKTGKMLWQATHDKLPSGRVNDWPEQGICSSPYVEGNRLWYVSNRCEVVCADVEGFLDGKNDGPYKDEKYAEKEDADIIWVYDMIDELGVFPHNLATASPVVAEGLVFALTSNGVDEGHLNLPSPEAADFIAVNKDTGELVWERNDCGKRTFHGQWSSPTYGMVQGKSQIIFGGGDGWCYAFEPKTGKPIWKFNLNPPDAKYILGGRGTANEIIATPVIHDDKVYVCVGQDPEHGEGIGHFFCIDATKTGDITESGKVWHIGNEDFHRSISTCAIADGLVYAADLSGFMNCLDAKTGKRYWVHDTMAAIWGSPYVVDGKVMLGTEDGEVLVFEHGKEKKLIATNDMGSSVYTTPVASNGVLYVTNRKEVFAIEGKK
>NZ_CP036352.1|WP_145124530.1|202881_205254_+|PQQ-binding-like-beta-propeller-repeat-protein
MKNAEGRMQSPGQTSCAVPGGRAVAARFLDTQSFIFHSPRPTAIRAMVLTAIALGIAVPSPVDASDWSHWRGADQNGFSHEYGTVKKWSLDGENLLWKSPEGGRSTPLVMGGRVYYIAPAGDGACLQERVICLDADTGKTVWDYRFNVFFSDIVAQRVGWTALAADPETGNLYAHGTGGQFICLSKDGKLIWQHSLTEEYNRVSGYGGRLMTPIVDEDRVIVSFLNTNWGNHAKPGHRFVAFNKHDGSVVWWAEPGGPPVDTTYGTPIVMVVDGRRLLVAPCGDGVVYGMEARTGKVVWSYALSKLGLNVSPVWVGKHVFISHSEENRDSTVMGRLVCIDASKTGDITQSGEVWRIDGLDAGYASLAYANGRVYAVDNSATLFAVDAVAGKVAWKYKLGRVGKGSPVVTADNVIYVGEQNGIFCILKDAGAHCQLLSRQEFAPREGGAIDELYGSPAVCGGRVYFMTRYGMYCLADKSAKVQTADATPQPKETPGDDMKPATIQIVPADVTLMPGGRQKFEVRAFNSRGVPTNESAGPLEWSLTSNLRGIVSQDGTFSAMDKIPFTAGLLTVSGGGLSTEARVRVSPWLPINEDFERNREGVPPGGWIGVGGKTRITKHDGSMVFQKLAEKGKPSPVWKMRAYATMPIPGGYTVEADLQGTLARKRFRPDMGVINSRYELIVLGMQKELELARWRDEPTHALRKRIPFELKENAWYRFKLRVELAGPKALVRGKVWLRDEAEPKDWTIEFEDTCPNPEGSPGIFVYSNGTTDKSDGAEVYIDNFKVLVNQ
>NZ_CP036352.1|WP_145124529.1|201562_202885_+|AMP-binding-protein
MSFHVRQDETLSPEGLAKLQRAKLARVLDEAARGSRFYQIKWDGLDLEAIGRAATAEAALGLLPLTTRSELQQDQLAAPPFGTILTQPVNQYTRLHQTSGSMGVTLRFIDRPEDWAWWKHCWSIVYRAGGLTPEDRCVFPFSFGPFVGFWAAFEAAAAMGNLCLPAGGMTTRARLDYLLANEATFVCCTPTYALRMAEVAREAGIDLAASRVRALIVAGEPGGSIPATRERIESEWGARVLDHAGMTEVGPYAFECIEAPGGMHVTESEFIAEVIDPHSLKPVAAGHPGELVLTNLGRLGCPLIRYRTGDLVQLVRGRCACGRSFARLVGGILGRIDDMVTIRGNNVFPGAIEAILREHPGIVEFQLQALTDGALAELRIDLEPSPGMDVSELPEAVARAVKDRLNFRPTVRLVAPGSLPRFEMKAKRWIRTSGNVENVE
>NZ_CP036352.1|WP_145124528.1|199326_201432_+|MFS-transporter
MKTLFSNPSTCPPRSPRTSAAPSGLSAPRARCSSRMSDATSPRSEAGYAAASLGAVADVPLYRNRNFVLLWLAYGVSAFGDHVSEMALLKMQDALDPSVTDVTRRNAIMLFAFMAPFFCFGPIFGWLADRLPRRAIMVAADLIRAVVILEMFAILTGIHERLGHAPGAPLTVGVAILPLALLGVFAAMFSPARLSLLPTLVRTDQLIRANACTAGLGMIASIASFLVGAMLVERYSVRANFVLDAATFLVSAALVFAVRPPAAVHRAPGEHGLRAVTESFRYVRTHRRVFEVILVSTVFWAGASVVRSIIPALVKDVFGGTYEQIGLFQGLLGVGLLVGSVVLTLLGSALRSELAISWCLKLTGLAGLFLTAVVLLAWGRVAGAAAIFMVGFFGSGIGVSVNALLQRIVPDSHRGRVFGVNDMFSIAGLLGATGALGIPDWPEIDKHISWITAIVSVALIGTGVWTTRVRLRRGRHGTWLTFWRNLNGFYCAWMPRLRRIGRCTIPVEGPVIVAANHNSVLDPFVLTAGSSIRSIGYMIAKEYAALPLVRGMCRAIEAVPVSRSGNDTASIKAALRHLSNGKVLGIFPTGRIVPRLGPQEPREGVGMLALRSGATVIPAYIDGLRPAYDWTSGTAAQRSRWANLLDVLSMILPFFQRHHATVRFGPPVDLSAFAGREKDRDAYAEASARIMDAILVLRGQP
>NZ_CP036352.1|WP_145124527.1|198695_199439_+|PH-domain-containing-protein
MTCPKCKVTIEADSVFCRHCGTRVGPGAKTASPQDGVWSTSAPRPGTGPATAPAASSPAPASASAAAPESLAPHAPPGSETYRDPAHEKEVWRGRPAWKASASIWALWLAGAIALTVLVYKYVDQGSRLRDFAWGVIAAAAVVIVVRHAMVVFSRQYRLTTQRLFIHRGILSRTTDQTELVRVEDVRLKQGLVDRILNTGNVEVIGSDRTDENVVLESIDVPAEVAENIRRTVRAVRTKGTLFIENV
>NZ_CP036352.1|WP_145124526.1|197959_198688_+|superoxide-dismutase
MSTRREFISGLSAFGGLALLPGCAGAASAMSMVEEDGGGPPAEYALPPLPYDYKDLEPHIDEETMRIHHGKHHKGYVDGLNGALKKLAEARASGDLAGVPALTRQLAFHAGGFFNHVVFWNNMAPSSKGGGGQPSGKLADAIQRDFGGYDKFTAHFTAATTTVEGNGWGVLAYHAALRRLVVFTMLNQQMGTPVGTTPLLMCDVWEHAYYLKYQNRRPDYVKAWWSVVNWKDVEARYAAAMK
>NZ_CP036352.1|WP_145124536.1|210795_212154_+|aminotransferase-class-III-fold-pyridoxal-phosphate-dependent-enzyme
MSKSISLPVCDHKPRPYTGPSRAEALALRQQYLTPALITYYKDPLMVVEGHMQYLWDETGKRYLDAFAGIVTVSVGHCHPKMVERVRDQVGMLQHTTTIYLHPTVGQYAKKLADHMPGDLKVTYFTNSGSETNDLAILTARAYTGCFDIIGLRNAYHGGSQSTMALTAHSTWKYATPHAFGVHHGMPGYCYRCPLGLTYPSCDVKCARDIGEVIKFTTPGKVAAFIAEPIMGVGGAVTPPPEYFKIVYEEVRKAGGLCIADEVQTGFGRTGTHFWGFQNWDVMPDMVCMAKGIGNGTALGAVTTTPAIAKALTGKLHFNTFGGNPVQATYGMATLDIIDEEGIQANALKVGGELKAGLTALMDKHKLVGEVRGMGLMLGVELVKDRVSKEPAKEETAQLLELARERGLLLGKGGFYGNVLRIKPPMCITSADAAYMVAVVDEALGIIGSGVK
>NZ_CP036352.1|WP_145129654.1|212264_212567_+|nucleotidyltransferase
MKRNILPSDAIADYCRRHNISQLSLFGSALRDDFGPESDLDVLIEFSPGHSVGLIRLAQLQRELSELVGGRSVDLRTAEDLSRHFRDSVIAEAEVQYAEN
>NZ_CP036352.1|WP_145124537.1|212553_212889_+|DUF86-domain-containing-protein
MQKTDRIRLQHMLEAAELAVQFCEGRTSGDLDSDPMLVLALVKSVEIVGEAAAKIGKPTRDLIPNIPWQAIVDMRHRLVHAYYDINHTILWLTIQEDLPPLIQQLQQALQT
>NZ_CP036352.1|WP_145124538.1|212922_213828_-|CPBP-family-intramembrane-metalloprotease
MHNPPDKPHAPVARPIVNESPAPRAAFTTRPVDYAADLDQPTAPTGFPRLTLSRRAALADIFAVVALVALYETATILSGLHETLHVLVPRGGLYVGIVLNGLFCLGAVSAVLKLRGQSPADLGLTPIAPRRLLGWTAAAVPACYALGAAAVITTLIATGRNILEMADERTVFLDRMSDINVSWIAPVVLFVGVYEEILFRGFLLPRLRTIFGNDAGAILVSAALFGAAHYPTQGLEGAMQTGAVGLVLAILVTRLRNLWPAILTHAAIDGISLLATIVFLPAMQEALNTLTTQPTSGPIVP
>NZ_CP036352.1|WP_145124539.1|213904_214906_-|hypothetical-protein
MQKMPLSISLRGFATQTPAGETLLLPFEQIHRDSLGYLILNQNVTPSCHPQCRVNTGLLELSSCIQRLTQRKIRQQLQSGNYRMRLKCKRAGITEWVFAIGLFVWTPLLLMSSDVLSRGRAYSPFETPTPIWVWCVLTVLVIMICVLPLLLVVLKARTLLTRMTAAFSRRIPTEIRTIASGIVVEYSDDTIDLFRLCEIESFVRLGGIRLKSRRSIMFDVVQDGISCWRTFYLAANRAIGAAHQGFFVKGSIPRSTLCPMLLISTLLVIAAISVNFKMDVQPDQRNVTVALGILHAIICLPFVINWRRVRHWLRRNNHTKILAMFAPSCSFKA
>NZ_CP036352.1|WP_145124540.1|215007_216405_-|hypothetical-protein
MSDQTQSTDRLASLLKPALAQWPATGEPAVSKAPGVIDVMGGIGEDSGSLVITSTAGVSFTVALWATAEPNLAVRFCSEGGEATPRDFVRPLGGLLSAAPEAIITEAQSASAEWAAPVLLAVRHAIAHGGFARPTGGFAALVLTDFPPDADLGRHAALSTATIDALCRLSAAPRERLDKAALAADAVLALTGIPAQRIALTALAGPVDGSLLQIQFHPQPKLDPLPLPHGIAVAAARTFLTRPTTPERLIETRACTAMSQLLIAELQRADGVAAPAHRLAAIHPTEYVERFRDRLPSKMTGRAFLEKFGELRGVNGCVVPADTYKVRSRAEHHIYENRRVHEFASLITRAKRNNSLEALAAAGELMYASHWSHSQRCGIGGVETDRLVSAIRKQGAAVGLFGAKVTGGGHGGEVVVLKRADDTARSALAAAVREAQTASNRTIHTFRGALPGAEFFNPAQAMATA
>NZ_CP036352.1|WP_145124541.1|216464_216872_-|bifunctional-nuclease-family-protein
MDVRMDLSRIVIQDTSDQQVIFLRERDGEREFPIVIGDNEAYAIDRRLKGLKKARPMTHDLLADIIERMGGELEKIVINDLKNHTFYAKLVIRSNGEMIEVDSRPSDALALGVAAAPEPTPIYVSEHVLREVLGQ
>NZ_CP036352.1|WP_145124542.1|217128_220668_-|class-I-tRNA-ligase-family-protein
MAKSDSKAYDSAAVEARIFQRWLDAGHFHPAPDARPRDQRFSMVIPPPNVTGALHLGHALNNTLQDILIRRHRMAGHNTFWLVGTDHAGIATQATVEKTIRKDEGKSRHDLGREEMVRRIWEWKQKYGSRIVEQLKLMGCSCDYQRERFTLDEGCAAAVRETFFKLFRDGLIYRGKRLVNWDTQLQTAVADDEVYHETVKGHFYHFKYPIIGSKPGEPTHVHIATTRPETMLGDTAVAVHPEPDAALEVAETQMQVKLREASAKERPEIEAKLADIAERKRTLLPTLLKLRDMAKGSASVPPAKILLPLVNREIPLICDDWADPTLGSGCVKITPAHDANDYAVWERSQQHADASRRLAIINIMTADGKVNEHGGKYAGQKFADARKQVVEDLQNWTDPKTGQSHNLVEKIEDRQIDLAHSDRSNTEIQPYLSDQWFVKMGDLDTEHAKRIDDLHGATGLAQMAIDAICKNDAHYDDPAARANCDKVHIFPRRYEKTYTDWLSAKRDWCISRQLWWGHRIPVWAYRPFGDRNTRPSIDGAVGQGQKIIELHEKLATWAKEGRAFLKFAEDAEANFPEIGMRRACAEQYIGVSNPADAEIVAFLEGVGFEQDPDVLDTWFSSALWPHSTMGWPGATQSDDTQRAAGFSLRGADASSERDAGTANEKGDGTASERGALDRTAARAEARGSLDKERGSFADARGSLALLNYFYPTSVLSTAREIITLWVARMVITGLYNTGKVPFRDVVIHPVIQDGQGRKMSKSLGNGVDPVDIIDEYGADALRFTLAELATETQDIRMPVQKKRLPDGREINISEKFEKGRNFCNKLWQAATGYVLRNLDGYDPRPLDPKSLRLEDRWILSRLTAAQQTVDAALTRYRFADAVGTLYRFMWDEYCSWYIEMTKSRLQASERDAPDSTAARAEARGSLGARGTFPEAGGSDQSARGVAQQILVHCLDQLLRMLHPVVPYVTEAVWQELNAVAPHRGLRDIPDAAATQPDLIAATWPAPEANLRDEAVEREMEVLHNIIRSARDIRASVNDYRGKSKQPSMRTLPAIAIRADATACKLIETYRAFILPLAGCDALTAAPDAPKPRGAMGRVMGALQVYAPVADLIDLAEVRKTDEARLAELKKSIARDEGKLASADFVSNAKPEVVEQARQRVAELRAQITALEEHLKELGN
>NZ_CP036352.1|WP_145129656.1|220986_221397_+|arsenate-reductase-ArsC
MKRVIILCTGNSCRSQMAEAFWRKHGGADWEVVSAGTRPKGAVYPPAIRAMAEKGIDINRAESKSTGPFIGQKFDLVVTVCDDAEKNCPTFASAAKHLHWPFDDPPKATGTDEQRMQVCRRVRDEIEAKIKSYLGK
>NZ_CP036352.1|WP_145124543.1|221647_223054_-|aspartate-ammonia-lyase
MSAEFRTEKDSMGTMQVPADALYGASTQRAVENFPISGYVFTRPYIRALGLIKLAAAEANAQFGTVPKDKCDAIIKGAQEVIDGKLDRHFVIDIFQTGSATSTNMNANEVIAHRAMQLVSGAKIHPNDHVNQSQSSNDVIPTAMHVAACETLRNDLIPALEHLADALDDKARAWDNIVKIGRTHLQDATPIRLGQEFSGYAAQARLGAMRCQKAVRALRELPIGGTAVGTGINTPMGFGAAVAERLASKTGIDFVEAANHFEAQHAKDGFVEASGLLKTVAISLGKIANDIRFLGSGPRCGIGELKLPATQPGSSIMPGKVNPVMCEMLMQACAHAIGSDAAVTHAAATLGNFDLHVGMPVMAHNFLEATRILSNAVRVFSDRCIAGLEADKQRAEQLVEQSLAMCTSLAPVIGYDNAAALAKKAYETGKTVRQVALDQNVLPADQLNKLLDPRAMTEPGASAGPAGG

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Crispr_ID: NZ_CP036352_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036352_2

458019-458204

Orphan

Consensus_repeat	Method
CGCCAACGTCAACAACAACACGATCAC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP036352_2

>merge|NZ_CP036352|2|458019-458204|PILER-CR
CAACGTCAACAACAACACCTTGACCGGGGCGACGGGTTATTCCGCCATCTATTTCGACTACGGGATCGACGTTTTCTCGACCGCCAACATCAACGGCAACACGATCACGGACTTCGGTGATTACAGCATTTACATGTATGACATCACCAGCAACTGCGTCGCGAACGTCAACAACAACATGATCAC

>NZ_CP036352|2|1|458019-458204|PILER-CR
CAACGTCAACAACAACACCTTGACCGG	GGCGACGGGTTATTCCGCCATCTATTTCGACTACGGGATCGACGTTTTCTCGACCGCCAACAT
CAACGGCAACACGATCACGGACTTCGG	TGATTACAGCATTTACATGTATGACATCACCAGCAACTGCGTCGCGAACGT
CAACAACAACATGATCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036352.1\|WP_145124732.1\|471920_473024_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124735.1\|477367_478477_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124727.1\|465052_465277_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124728.1\|465491_466478_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187673
NZ_CP036352.1\|WP_145124716.1\|435607_436696_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372616
NZ_CP036352.1\|WP_145124720.1\|445452_446664_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|223533
NZ_CP036352.1\|WP_145124724.1\|455300_456782_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275366
NZ_CP036352.1\|WP_145124718.1\|439680_442518_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274784
NZ_CP036352.1\|WP_145124733.1\|473157_474696_-\|SpoVR-family-protein	unknown	unknown	gnl\|CDD\|377285
NZ_CP036352.1\|WP_145124723.1\|454287_455244_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124721.1\|447152_449060_+\|activator-of-(R)-2-hydroxyglutaryl-CoA-dehydratase	unknown	unknown	gnl\|CDD\|226109
NZ_CP036352.1\|WP_145129675.1\|452779_454231_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226108
NZ_CP036352.1\|WP_145124731.1\|470876_471830_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|179554
NZ_CP036352.1\|WP_145124719.1\|442872_445128_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124726.1\|461233_464848_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275366
NZ_CP036352.1\|WP_145124730.1\|468283_470803_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|379142
NZ_CP036352.1\|WP_145124722.1\|449100_450072_-\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187579
NZ_CP036352.1\|WP_145124717.1\|436710_439488_-\|fibronectin-type-III-domain-containing-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145124734.1\|474719_475811_-\|DUF444-family-protein	unknown	unknown	gnl\|CDD\|235409
NZ_CP036352.1\|WP_145124729.1\|466462_468220_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236443

Protein	Function_ID	Function_description	E-value
NZ_CP036352.1\|WP_145124728.1\|465491_466478_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187673	cd09813, 3b-HSD-NSDHL-like_SDR_e, human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs. This subgroup includes human NSDHL and related proteins. These proteins have the characteristic active site tetrad of extended SDRs, and also have a close match to their NAD(P)-binding motif. Human NSDHL is a 3beta-hydroxysteroid dehydrogenase (3 beta-HSD) which functions in the cholesterol biosynthetic pathway. 3 beta-HSD catalyzes the oxidative conversion of delta 5-3 beta-hydroxysteroids to the delta 4-3-keto configuration; this activity is essential for the biosynthesis of all classes of hormonal steroids. Mutations in the gene encoding NSDHL cause CHILD syndrome (congenital hemidysplasia with ichthyosiform nevus and limb defects), an X-linked dominant, male-lethal trait. This subgroup also includes an unusual bifunctional [3beta-hydroxysteroid dehydrogenase (3b-HSD)/C-4 decarboxylase from Arabidopsis thaliana, and Saccharomyces cerevisiae ERG26, a 3b-HSD/C-4 decarboxylase, involved in the synthesis of ergosterol, the major sterol of yeast. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid sythase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	6.14115e-85
NZ_CP036352.1\|WP_145124716.1\|435607_436696_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.88277e-13
NZ_CP036352.1\|WP_145124720.1\|445452_446664_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|223533	COG0457, NrfG, FOG: TPR repeat [General function prediction only].	2.83165e-09
NZ_CP036352.1\|WP_145124724.1\|455300_456782_-\|hypothetical-protein	gnl\|CDD\|275366	sd00002, TSP3, Calcium-binding Thrombospondin type 3 (TSP3) repeat. TSP3 repeats of the vertebrate thrombospondin (TSP)-1,-2,-3,-4 and TSP-5/also known as COMP (cartilage oligomeric matrix protein), and related proteins. These short aspartate-rich repeats are a continuous series of calcium binding sites that can be divided into two sequence motifs: N-type and C-type. N-type and C-type motifs are distinguished by their sequence length, calcium ion binding, and their interactions with water molecules. C-type motifs are higher affinity binding sites compared to N-type motifs.	8.15661e-10
NZ_CP036352.1\|WP_145124718.1\|439680_442518_-\|hypothetical-protein	gnl\|CDD\|274784	TIGR03790, conserved_hypothetical_protein, TIGR03790 family protein. Despite a broad and sporadic distribution (Cyanobacteria, Verrucomicrobia, Acidobacteria, beta and delta Proteobacteria, and Planctomycetes), this uncharacterized protein family occurs only among the roughly 8 percent of prokarotyic species that carry homologs of the integral membrane protein exosortase (see TIGR02602), a proposed protein-sorting system transpeptidase.	7.41486e-19
NZ_CP036352.1\|WP_145124721.1\|447152_449060_+\|activator-of-(R)-2-hydroxyglutaryl-CoA-dehydratase	gnl\|CDD\|226109	COG3581, COG3581, Uncharacterized protein conserved in bacteria [Function unknown].	1.77984e-54
NZ_CP036352.1\|WP_145129675.1\|452779_454231_+\|hypothetical-protein	gnl\|CDD\|226108	COG3580, COG3580, Uncharacterized protein conserved in bacteria [Function unknown].	2.62797e-88
NZ_CP036352.1\|WP_145124731.1\|470876_471830_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|179554	PRK03204, PRK03204, haloalkane dehalogenase; Provisional.	8.54223e-48
NZ_CP036352.1\|WP_145124729.1\|466462_468220_-\|AMP-binding-protein	gnl\|CDD\|236443	PRK09274, PRK09274, peptide synthase; Provisional.	0
NZ_CP036352.1\|WP_145124726.1\|461233_464848_+\|hypothetical-protein	gnl\|CDD\|275366	sd00002, TSP3, Calcium-binding Thrombospondin type 3 (TSP3) repeat. TSP3 repeats of the vertebrate thrombospondin (TSP)-1,-2,-3,-4 and TSP-5/also known as COMP (cartilage oligomeric matrix protein), and related proteins. These short aspartate-rich repeats are a continuous series of calcium binding sites that can be divided into two sequence motifs: N-type and C-type. N-type and C-type motifs are distinguished by their sequence length, calcium ion binding, and their interactions with water molecules. C-type motifs are higher affinity binding sites compared to N-type motifs.	5.56044e-13
NZ_CP036352.1\|WP_145124730.1\|468283_470803_+\|trypsin-like-serine-protease	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	5.86922e-25
NZ_CP036352.1\|WP_145124722.1\|449100_450072_-\|NAD(P)H-binding-protein	gnl\|CDD\|187579	cd05271, NDUFA9_like_SDR_a, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs. This subgroup of extended SDR-like proteins are atypical SDRs. They have a glycine-rich NAD(P)-binding motif similar to the typical SDRs, GXXGXXG, and have the YXXXK active site motif (though not the other residues of the SDR tetrad). Members identified include NDUFA9 (mitochondrial) and putative nucleoside-diphosphate-sugar epimerase. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.33253e-38
NZ_CP036352.1\|WP_145124733.1\|473157_474696_-\|SpoVR-family-protein	gnl\|CDD\|377285	pfam04293, SpoVR, SpoVR like protein. Bacillus subtilis stage V sporulation protein R is involved in spore cortex formation. Little is known about cortex biosynthesis, except that it depends on several sigma E controlled genes, including spoVR.	0
NZ_CP036352.1\|WP_145124734.1\|474719_475811_-\|DUF444-family-protein	gnl\|CDD\|235409	PRK05325, PRK05325, hypothetical protein; Provisional.	1.25832e-140

>NZ_CP036352.1|WP_145124724.1|455300_456782_-|hypothetical-protein
MKRLPAHRVGITGQPSKSVSIRPADWLMGESFMTRVRFSVAVLGIAALLGAADRAAASFHLMQIEQVIGGVGGDTDAQAIQLRMRANGEGQVSQGRLVVRDATGANPVTILVFPSNVANEAQGGRILIASNAFIAKSLPNAQADFTMTATIPSGYLAGGSLTFERNNNGGILWRVSWGTYSGSNAGETTNDADGNFGPPFGSALPSAGTSALTFGGTAGAMSTNNAADYSIPAGAATFTNNRGCEFVVNAAPACGATDTDGDSTNDDCDSCTDSDGDGFGDPGFPANCCAADGCPNDPNKTAPGDCGCGVADDDADGDGVLDCNDTCANTPAGQSVNGEGCSCAQLDPNADSDGDGVTDCNDVCPNDPNKSTSAGACGCGNAETDTDGDGTPDCTDGCPNDPNKIAPGNLGCGVAEADADGDLIPDSADNCPNVSNADQADEDNDGVGDECEAGHDDGGANCGQTGGCGAMGGSMLPLLLLGRGKRRRRGFRG
>NZ_CP036352.1|WP_145124723.1|454287_455244_+|hypothetical-protein
MAPSSPNADKLAAEDPLFYAMQEAVYEVTGKRVPFARDTRIDRYFIDVVGADSLEYLDLSFTLQDKLGVWIDDKDWNFLTGSREASSLQEWELKFAPLFTFGRLTDLIASRARFAPPAPVTILGATSNAAGAFRYICEAAREVAPRVKSFGPSTAIHERFKGRKLRRLWERLRMMSCGRIPPLKATRYERIADFMSNTGGVLTVIGLSCGSVSLFSRIYGFGATVDWLGWLFMVLLSSVIIAGFFAVVAVVLAFVVRRLGKASFNSNLPNGIATFRDLSELIAGDRGGWCDQCGYDLTGLTGDVCPECGKNIAHPIGK
>NZ_CP036352.1|WP_145129675.1|452779_454231_+|hypothetical-protein
MREIKAGLDAIKKAYPNFAEICAREAFAPADVPCVADDVAEAEKAAAGFGLPDRLVLPAVRRKREAARQRVELLKKRGDIRIGMPRVLNMYSMGPWFMGYFQALGIRSANLVWSDYTSEENYKEGAKRGAIDPCFPSKIGIPHVHNLLYHKHTEKQPLHYIFFPMIDCMPTFMDNIQSSRACPTVTATPEAVKAAFTKESDLFADHGLQYLDTFVNFSEPGLLARQMFAEFADKLGLSPEENARACRVAWDYYDGFYADLRRQAREQIDQLEAKNEVGVVLLTRPYHHDPGVCHEIPDEFQKLGIPVFTMDVLPRDPDILERLFGEEVRRGDFASPVSIEDAWKNAYSENTNRKVWAAKFAARHPNLVALELSSFKCGHDAPIYSVIEEIIETSGTPYFCFKDIDENKPTGSIKIRVETIAYFLRRHREKLAMRQAKMAQIEAQLAAMERELRARSGTVHGAAAISAHPARDASVDRGVVVGV
>NZ_CP036352.1|WP_145124722.1|449100_450072_-|NAD(P)H-binding-protein
MNLSLECRRVSQSVLHVVTGAFGYSGSRIAQRLLDRGVTVRTLTNSRRPSPLANRVEILPLAFDDTAKLVDSLRDADVLYNTYWIRFNHGDFTRQQAIRNSLKLFDAARHAGVRRIVHVSIANPDENSPFEYYSGKAWLERAIRESGLSHCILRPAVLFGDEDILVNNIAWILRRFPIFGLFGDGSYGIRPIHINDFADLAVRQGFETESLAVDAVGPERFTYRELVREIARILKLRRLILPMPSAIGYHIGRAIGGYVRDMVLTRDEIGALMAGLLDSNAPSTGETRLTDWARENAATLGRYYASELSRRSDRHQSYTALQR
>NZ_CP036352.1|WP_145124721.1|447152_449060_+|activator-of-(R)-2-hydroxyglutaryl-CoA-dehydratase
MVANATTTAKPTPGESGTVALPLLRDSIDATIAAERERLMKEAGLTVGPIQHFKRPVERNFTRSERGKVTIWLGGLTLRHEMLIVAGLEGLGYKVGLIPTPVKADFQAGKEFGNNGQCNPTYFTVGALVNHLKRMRDEQGIPLEQILNDHLFITAGACGPCRFGMYEAEYRLALRNSGFDGFRVMLFQQSGGLDQAAVEAGLEFNLNFFLSLLNGMFMGDILNEVAYQIRPYETVPGQTNAVFDKCLKICQEALKKKNYDEVHQGALAKILAKVAPVKGPADAAKFLDQLRGTYYAETFAECAKIINEEIEVDWLRAKPIVKVTGEFWAQTTEGDGNFRMFPFLEGEGAEVLVEPVATWICYMLHQAGLKAGDRKGLDKTSKRQNTEMPRQEEADGSQSVGVGDHGAGDADRPSRWNLKARLAAELAFRKKMFTFDIAEKIIKHEYNKLREAIGGTAHELANQLELTRAGHPYYNSRAGGGEGHLEVAKNIYYSSKDLAHMVLSLKPFGCMPSTQSDGAQAAVVSHYKDIIYIPIETSGEGDINAHSRVQMALGEAKVKCKDEFKRAVASTGYTLEQIREYVAREENRDLRRPLLHVTHRKGVIGKAASFVLDVGERMKKEGVAVGEEAREAVCV
>NZ_CP036352.1|WP_145124720.1|445452_446664_-|tetratricopeptide-repeat-protein
MSRSVLPALVAVAASISLAHESFAGGIPSRGSGSTCNSGFSSRIVRIPGPDPLCRSSVGTMQYYYTPPRPIYTQSGATSPFFDTYRHTNHPVRAFNTACNDRFQAGGIVRYPVITPGRFGTPGFGSRTTPYGNYAPSFGGHTRSFGRSAPIYGRNNLSCGGIGPYSSGWVANAWTDSWVVSNPPPFAYDPLFYYEREVTIEQRQQFRDLASERAGYLINQNMELFDDGMAQFNAGNYEQAAIKFLGAADADHGSAAARLHAGHALFALGRYDESVVQLSRAFELSPLLVSRDYDLRDEYGERAEFDRHLDALKAHVVRNPKDAAARAVLGYVLFRTAGSAAAYPVLRHAAQLDPRSYFVPKLLEVVGKTAPANGAGRNPSAPARSKSGPASPRASQSKLVKGK
>NZ_CP036352.1|WP_145124719.1|442872_445128_-|hypothetical-protein
MAKFDEDGPGPRPASWFVGGDFSVSYWLYASSSWCQSLGRYEGGTLGRVGSSVHPNFTGPVFALQVFDDDGTGPIPEALYACGNFTLLQSGEVICKIARWNGNKWFALEACDYFSGTLRAMTVFDDDPDDGVPPALYIGGDQYLYKWDGRNLTVVNNRQSLNGTIHSLAVYGDPNNPYNKPAIYAGGDFTAAGSTPVRFIAKWMDDLWEPVGDGFSAPVSSTAVFDDDGEGGQPPFLYVATDEFPSNGVPIARWDGSNWSTIGYFPCNCEVGVNSLAVFDMDGPGPQRSSLLVGSFGILARWDGDQWSVFPNEIMYWWGNDSNAFGALATHEPACGDGDAELLVGGRFSTFSSYGSKLLAKWSGRWSYVMAGIGSASPFTQYVPPIAVGTNREGRSILFSKSYNGFLQRWNSRKWEPLALSVTPPFDVSALQTPASSALGEILLGGRGNFGSGVAPGIAAWSEATGYELLGPPLASGSTINALVEVIDDPKGTLPGGVYVTGKLKRPGSSTFEIALRWDQTGWHSLGAPFNATGTAYKCILFDDDGDGPAPPTLIFGGNFVPTNGSRALSRIARWDGRHWIAMDKGFLGTVYQLVVADPDGDGPRIGALYAIGHLALPGQPLMETALHWSGQEWEPIKGFQQISYIGYIDRDGYGPQTPTLFLIGRRPGGNTSYPFLFWQKGEDWENSGAMFALSGPDRPCASVLFDDDGDPATPSATYISTTEFLYKGLRSNGIARFGPPLSVGLSPPVP
>NZ_CP036352.1|WP_145124718.1|439680_442518_-|hypothetical-protein
MLSCDGTSQTTMRAGFACAMRRCAWVAAWMCISLMSGNAALAGGGGENVLLIINPESPSSLYLGNYYKNARNIPDANVIYYKSEVSSYANFADRSVDALFGALQHRGIDDHVDFVVIPPGEGFAVFSPGLIGASGCTPVTRLSISSAYGLAYYRSLILGGTMNVMEPNQFYSNSPAARAFRNSLSYAGGVPSTAPAAKRYYIGFMLGNDGFNGNTLDETIAMIDRSVAADGTRPGGTFYFMKTTDTVRSNPRDPLFPAVINEIIANGGQAVQIDNQDLPAGQHDCLGILTGAATPNIDGTAMTITPGAFCDHLTSYAATFEDTSQVKLSRWIAKGFPANGASGSMGTVEEPCVFGPGIPGKFPHPRLHAWYYQGVCLGEALFRSIQWAPFQGLFYGDPLTQAFAYIPTVSVPDAPGGAVSGTINLTPNSTATRPGATIANNELFVDGRLLGSVAAGGQFSLNTTTLADGHHDLRVVARETGLIATVGRWTGTLQTNNFGRSATLSANPPSGDRSTLFTVNVAAAGGAVTEIRLLHNARVIAATQGASAAFSILGDVFGGGPVRLVAEAEFSDGKRALSAPVNLNVTYANPPAGAMPNHAPVAYSYTRDVTTFGAFLIELPASDEEDRITTYNVLSGPAQSTLISSVGGPTLLFRRSGTSAGTDTFQFSVSDGQVTSNTATITLRYSGIAPDTAAPSPNPMQFLTAPAGISSSEISMQAVLATDTTPPIQYYFDYVSGAGGHDSGWQLSRDYIDTGLPANSSFNYRIRSRDSVTPTPNTGNFSSNFTAATHIETPTGVTIGTVTANSVQLTAAGSFTNVGFLQTAFFFEVSPPHGTGGNVWTSSPNASITGLSPCTSYTFRVRARNFQATETPFSPATIQATVGCPTCALSGDVNNDAARNGLDIAGFIRVKLGMALPGDNAACADYNTGTLAGDIAAFAADLLGP
>NZ_CP036352.1|WP_145124717.1|436710_439488_-|fibronectin-type-III-domain-containing-protein
MTNRFRLLAAIASALSIVTPGAARAESVDRATPVAIKGERLPPEAFGPSVIESMDEVIARDALRAPEPPVKKRDDFGLWTVPSIRATYFPNSGHHNLVNKSGDTHMGIGFARPVRLDRVFVAGQGAPEVWTPALRVVGYRDGKQVGETAWYHDISDRPTVLDVNLDNVDRVVFESIATVAGGGFYALDDLTFTYRDTGESVTLDFEELPYGQVLTGTGYADLTWEVGEGVTADCGDAIAAPQTFAQPQAAQPAENDDGLWLLRAGTQPLLTLNFQGVKRGDAGQFSYPPDTCGAVGPTQFVICVNRNIAIYNKATGAQQSNVSITSFLPGSSGDPRVLFDHYTNRWVVLNDDFNSRLYLAISLTSNASGSWFKTNFLVTGGSDGSCWPDYPTLGLDANGIYTGAYMVGCQMSLFCVDKAPMVAPSPTLGTVTAFRGLPWEGALQPTMTYGNPPGEYVVSTNSNNGIRVRRVDPPLTDPTLVEVGIVPVSSWGDASDAPALGGPALDTVDSRLMNAVYRNGSIWAAHTVSGGAGATCRWYQLAEGSPFTVAQWGAVGDATRWHYFPSIAVNEQGDAVLGCSGSKASEHAGCYYAGRLVNDPPGQMSAPALLKAGIGPQNNIDGFGRNRWGDYSLTTLDPSDSRTIWTVQEYADVSNTWGTWVGKLQFEDVDAVQPAPQPGFEIAPTAISSSAITMRSTEAIDADSPPVQYQFDYVSGAGGHDSFWQFDRDYVDTALPANSAFTYRVRARDNAAPNPNITPYSPSVATATAIQTPAGVNVSSVTADSATVTATGTFTNVGFLQTGFFFEVTPDPGPGSGAAQWGGSATRSLSLLSPCTQYVVRARARNFQGDETPFSEPVLFATPGCVCNLPGDVNGDESVDGLDVAAFLRVKLGAPLETDLPHCADFGGPDLESDAAAFSNALLSQ
>NZ_CP036352.1|WP_145124716.1|435607_436696_+|methyltransferase-domain-containing-protein
MGRENCRPGVEPADRNRVPPVRRSCDRAHHLSMTSLPAQFVASLTDSNADAAFVCVGCGHRKSRDAALPRGWPCPMCRCDACGLIQQSPRNSARSPVGPVNVSLNGDAQSESEAWTSAVQQYALCLLPLESSPGRNLLIVGCGRGHLAALAKSRGWRVVALDPSPHAVCRAIEQFGLDARAGGLARHREALGRFDVVVCGNLETSWDPAAVLRDTRTVLNTAGLVCVDVSDGFADWNPAMADASRNSQDAPLNLFNAESLEGLLRTCGLEMVAVHAGGKGSAPQLATNGLGVFRWIPQFIARWFSRLWGLFAGGPAKGCPRSAARDLSEAVAQIEATASRPTAQRGRANRLLAVATRAALAG
>NZ_CP036352.1|WP_145124726.1|461233_464848_+|hypothetical-protein
MSRTHTKLVQAICMTAVVSTLASAARAVDINVPGDFATIQAAVAAASAGDRILVGPNTYTTPAGGLVLNVSNLQLLSTAGSATTIIENNTAGMPVIIIAAPGVIVGDVGQGFHIRQLQAASDAIEVQADQVKFGVPTTIQSNRISGNDSDDGIYVDDFIEAGLFIVQNNTFDRNGGTYSFYRGVYFDSSDHPSTNVSTVCLYDSNVDILNNTLNDIDEDGFYFDDDVYKCNVNINNNTVMGLTGYCGVYGTDVFDIFSTLNINGNTFDAFSYGIYVYGIYSHGTCTINNNTVTDFDSDGIEVDYIYYQSTCTINNNTVTGDGTAGEGIYPYDTDYASTTTVSGNTVSGIDYCGIYAYYNYYGSTVVITDNTVSSSTMMDYGIFVDTEYGSNTTITGNTISGFDYAGIDEYYPYAGCTVNISNNTCTADNGGGDYGIYVEDPEYGNTVTVNNNTASNFDYAGIYFGDSYDNTHITCNNNMLTALPTGGDYGIYLGDLYEYSTATFDMNTATGFDYCGIYNDDCYYTSDITITNNTLTGISSGADYGIYVYETAEGSDGTVNNNTCTNFDYAGIYYEYPSYEAGVAWINGNSLTALSTGADYGIYSYEVYTGQATYDGNTITNPDYCGIMLEYVDYGGSATISNNTVTMNTSGGDYGIYNYEVYEAGASLNVTGNTVTNYGNMGGGEAGFWQDDYTEYGSRLNVSNNTFTAHTNGSEYGIYSDGGMSDGCKGFFMNNVVEGYTYAGLYFYYTYDGSETTVTGNTFTPLANMGDYGILSDDGAEYGSTLNISNNTINSFTDTGIYYYYSYDGSHVAVNYNTINGDPNAGGYYGIYGDDGPEYGSTFEAIGNSIGGILGDVANDSAGIYTYYIYDGSQATICDNFIRGRTGEPGLYMSGLYFYYPPEYGSTLTICNNDIAGFWDASVYLYDDVEYGSSFHITNNKFDGGRFGIWTDGYDWIEGTDGSITGNTISNFSEVGIDANAIWGSIIDIANNRIQGNGSMAGVDIQDLVDGAAEVTIRNNCITGVDTGVEVEDIMDTAFVNVNGNDFDGVATTGIVNVMGLAANAIDGTGNFFGAVPTKATGEVDISGELGSAPDNDGDGVIDCDDACPETASGDDVDADGCSCIQLNPTGDADGDGVLDCNDNCPNVANADQADSDGDGVGDACSAAPPGPPPCGLLPCGPGTMMAMPFALLGILVMGRRRVR
>NZ_CP036352.1|WP_145124727.1|465052_465277_-|hypothetical-protein
MGMTQKRDSLAHRKSEIERELTGLGESRQASQDNTALGDLERALMAELDQVDRQLHLLDEYVKQLDQSSQPAGR
>NZ_CP036352.1|WP_145124728.1|465491_466478_-|NAD-dependent-epimerase/dehydratase-family-protein
MQALVTGGGGFLGRTIVERLLARGDRVRVLARGDYPDLRTAGADLVRADLRDRAAVIDACKGCETIFHVAALAGIWGDERRYREVNYDGTLNVLAGARTHGAARLIYTSSPSVVFDGRDLAGVNESVPYPLHYQAAYPKTKAMAERAVLDASNASFATVALRPHLIWGPRDNHLVPRILARAGSLRRIGHADPLIDTTFVDNAAEAHLLAADRLAPGAACAGRAYFISNGEPRPLWEIVNRILASGGLPPVTRRVPAWLANVAAVSMEATHRVLRIDREPRLTRFLVGELTKAHWFDIAAAKRDLGYIPRVSLDEGFERLDAWLKKPV
>NZ_CP036352.1|WP_145124729.1|466462_468220_-|AMP-binding-protein
MPILNVSSHLAQATKANPDQPAIIWRRGHGYARWSFSELNHEVDALAHGLAAAGVSRGTRTILMARPSAEFFALTFALYRVGAVPVLVDPGMGRRRMVQCLAAIHAEAFVGIPLAHVLRITNPVAFRSVRTAVTIGRRLAWGGHTLDSLRAMGGRAGRGAPFETTDTQPDDPAAIIFTTGSTGPPKAVLFQHRTFDAQVRMLREHFGIRPGEIDLPTFPLFALFDPALGMTAVIPEMDPTRPARVDPTKIIRAICDNNVTHMFGSPALLNRVGRFGEAMGLKLPSLRRIISAGAAVPPDVLKRFAALLDDSARIHTPYGATEALPVASIDHREILDDTASRTADGEGTCVGRPLPDATVRVIRITDDPIPAWDESLVLPQGQIGEFVVKGPMVTRAYLSSGEEHAPGATALHTGATASSNGLNQSSHSDSSTRANQLAKIPDGGDLWHRMGDVGWIDERGRLWFCGRKSHRVETAEGILFTEPVEAIFNQHPAVFRSALVGIGKRPHQRPVVCFELEESHRDTDRPKLIRELNELAARHDSTRTIHTFLINTRFPVDIRHNSKIFREKLAVWAAERLRKKPCRRW
>NZ_CP036352.1|WP_145124730.1|468283_470803_+|trypsin-like-serine-protease
MTVQRRMVATGVFLAFGAHRSRWLMKSFTCILMFAFLLPTVAARAQDALPERTLTKLKAATVFVKTKGPGQERRGTGFLVRKKGKIGWVVTNAHVLGQSGESDPVVEVVFHSGDPDELVLTGALAARDDAQDLAVLRVEAPRLPLPIDKAPKKKVDATLPVYILGFPLGEALAMGRSNPGVTVSKGSVSSVRKDSDGRIEAVQIDGEFNPGNSGGPVVDASGGLVGIATAKVSGTHISFAIPHENLQEMFGGRVRAITLSEKSNARGAMTLDVSADLSDPVDAVSRVAVLIAPKKPNDRLDRDSRGRYTALKGAKVCNLQKSRGAFRGEIKLQNRSTTSAEYWVQTRYVRGKNDNQLMEPRELSLTFDQSAPARKAKENESDGPEDGGEENADAEAVPPAKDSETKTPAVIDEALVAGGGRYLVLKLREMPALAVYDTWKGEMAGNLRLPSSQFVYAAGGDLAVVYFDEDNLLQTWDLAKLEKKLTKPNPVSGRVKNLLMGSARGDQAVVQFQASGSSTGDHYLLNTRTLQPVNKGGQPVMWRGHHSYFEHPGYLRANRDLTILTEWSRSGSPSGVTVHTRRGNEFTAKNDHTSAGFLAPGEDNRIYTGIGDLYSTDAVKVGSISGQSLFPGVGGGFYLGLRQEDGRISVYPCGKASPLCQWGVFPDWNKETQDQMRYVRSDAMPPDRRIVFLPTIGRIVMLPLDNQRVVMKKFDLKATLDESGIDYLVVTSAPPPTVQPRKAWKYQIHVLSKAGKPTYKLDFAPQGMKVSEDGLITWKPPAKLPPQGEKVVVLIRDAGEEELFHSFTLHGPGGAGASGGSSGSGNSSGAGVHRIEYGR
>NZ_CP036352.1|WP_145124731.1|470876_471830_-|alpha/beta-fold-hydrolase
MLGASSDWRALYPFQSHWLNRTGLRLHYLDEGSGPPVLMLHGNPTWSFYYRELVRALAPTHRCIVPDHIGCGLSDKPPAGRYPYTLDARVADVEALLDHLDIRDNLTLVLHDWGGMIGGTVAVRRPERISRMVILNTAAFLLPTGKPLPMRLRVLRDGGPLAKLMVQGMNLFAAPAVRMASAKGLPRDVAAGLLAPYDSWANRIATLRFVQDIPLAPGDASYNTALHTQENLDRLADKPMLICWGMKDFVFDSNFLAEWRRRFPRAAVHTFPDAGHYVLEDARDEVIERVRAFLPDARAHTTPSDAMRARAAPESVS
>NZ_CP036352.1|WP_145124732.1|471920_473024_-|hypothetical-protein
MISELNCLLFIVSAIAAGPEHGPKEVAKLPKNEIIVTATLDVPIERKRTMVYCASLQDAWKSLSKELSADSIQMDEASPLALQLNKGIALPTPTVPRAALMVRIMSSQKSVGQTSRELAARFGENAPRLEKMPGDHEAVLYTHAYLRPTFSEPFFTYKHTVFAQWPELYFVQSLTVPSVNEHARKRERIMPLIHIFEYDPPNLKVVAIQTAQPGEMLVLAQVPAVKTLQEAVDFVQAKIKNPPRNYNTEFEELDNLTFPKIHLQTRQEYVELCDRLLQASKDGFDRLAYAIQDIDFQLDSEGLLWRYRPSRIAVKGGRSRSRPYRRPISFDQPFVIFLTCDGAAPYFVAWIGDFTTLVPGKRLVVKG
>NZ_CP036352.1|WP_145124733.1|473157_474696_-|SpoVR-family-protein
MSLHRIRPDLARHAQEIAEIAKRAGLDFFETRFELVDFDTMQQIAAYGGFPQRYPHWRFGMEYEKLRKQHVYGLGKIYEMVINNDPCYAYLVEDNSVTDQKLVMAHVYAHCDFFKHNYWFSKTNRKMMDEMANHATRVRRHIDRQGYEDVERFIDTCYPLDNLIDPHSAFMQREAKRDETPSQTMSKEREIEKDVVRFKAKPYLESWINPPHRAEKQRQELMSQKKKEKHVLPRQPLRDVLGFLIEHAPLEDWEADILSIIREEAYYYAPQGQTKIMNEGWATFWHSRLMTRHILTDDEIITYADHHSGTVAMGPGQINPYKIGVELFRDIEERWNKGRFGKEYDECKDMEAKRRWDRKLGMGMEKVFEVRSIHNDVTFIDEFLTPEFVDRFKMYHYRFDPSTRRMVVVNRDFNKIKAQLLFMLTNHAQPYIYVVDGNYSNRGELYLAHKHTGVDLDIKYAVETLKDVQRIWRRPTHLQALINDEMVLFSFDGEQSQQQKIHADMPAPAHGV
>NZ_CP036352.1|WP_145124734.1|474719_475811_-|DUF444-family-protein
MKIDKDHQRFRQIVKGRIRDDLRKFLTRGELIGKEGKNIITIPVRGIDLPHFRYGDNNDGGVGIGEGQVGDGVDGDGEAGPGGSNPGNHLMEVEVSLDELADILGEELRLPRIKPKGNHQITSQKDRYSGIRSTGPESLRHFKRTFRAALRRQIIAGTYDPNNPVIVPIRQDRRYRSWKTVLKPQSNAVIVYMMDVSGSMGDEQKELVRLEAFWIDAWLRRNYEGIESRYIVHDVRAAEVNRQTFFHIREDGGTKISSAFKLARSILDTHYAPEEWNVYIFHFSDGDNSSESDSRECCRMLRDHMLPRINLFGYCQVASAYGSGNFINVIHEHLEEQQNVITSRVNTKDDIYDSLKTFFTPGK
>NZ_CP036352.1|WP_145124735.1|477367_478477_-|hypothetical-protein
MSNSINSSRRVADVARSALLALVIGLWIASTAAAQDTRESGDGPLPDYARRIELPAGLRVGPVDNLQLSNNGLPHILLTGYWPPTNEMVRQFSQSAIQNPGGWVGENWENRGYNIYSFFPEFPNGLNKGEGDFEVDYQDTSADWWPLLETMKPIALITFSRAANNRDWELEGGNRTYATNSWSPDYLAPTRPGPGLPIIDIEPPLTERFSTLPKPAIINAVLADPALDALNPYATVIDNGAFLSNYIGYHGNWWHDLHSSPADPAYNVGGGHIHVGYAMTLAEAVRATEVTLRAYTPHIDSIILNPRGDMNCDGEVNGADIAPFVLTLVDRPAYTVAHPTCFLRRADVNLDAAVSIEDVEPFVQLLLSE

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Crispr_ID: NZ_CP036352_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036352_3

1687914-1688054

Orphan

Consensus_repeat	Method
AGGCAGTCGTTGCCGCGGTTGCCGAAG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP036352_3

>merge|NZ_CP036352|3|1687914-1688054|PILER-CR
AGGTTGTCGTTGCCGCGATTGCCGAAGAGCCAGTCGCAGTTGGAGTCCGAGCCACTGCGGACGTGATCGTTGCCGCGGTTGCCGAAGGCATAGTCGCCGCCGCCCTCGGTGGAGAGGCAGTCGTTGCCGCGGTTGCCGAAC

>NZ_CP036352|3|2|1687914-1688054|PILER-CR
AGGTTGTCGTTGCCGCGATTGCCGAAG	AGCCAGTCGCAGTTGGAGTCCGAGCCACTGCGGACGTGA
TCGTTGCCGCGGTTGCCGAAGGCATAG	TCGCCGCCGCCCTCGGTGGAGAGGCAG
TCGTTGCCGCGGTTGCCGAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036352.1\|WP_145125689.1\|1676492_1677194_-\|PTS-transporter-subunit-EIIA	unknown	unknown	gnl\|CDD\|238129
NZ_CP036352.1\|WP_145125721.1\|1706110_1707178_+\|terpene-cyclase/mutase-family-protein	unknown	unknown	gnl\|CDD\|238362
NZ_CP036352.1\|WP_145125717.1\|1701795_1705368_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP036352.1\|WP_145125700.1\|1682676_1685361_+\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|234570
NZ_CP036352.1\|WP_145125711.1\|1696350_1697274_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP036352.1\|WP_145125696.1\|1680618_1681275_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_CP036352.1\|WP_145125692.1\|1677298_1678486_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223426
NZ_CP036352.1\|WP_145125694.1\|1679654_1680539_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145125719.1\|1705364_1706114_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145125706.1\|1693283_1693661_-\|DUF486-family-DMT-transporter	unknown	unknown	gnl\|CDD\|377316
NZ_CP036352.1\|WP_145125723.1\|1707210_1708452_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377970
NZ_CP036352.1\|WP_145125687.1\|1675302_1676295_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP036352.1\|WP_145125713.1\|1697315_1699448_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|131281
NZ_CP036352.1\|WP_145125698.1\|1681516_1682527_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|372616
NZ_CP036352.1\|WP_145125708.1\|1693835_1694810_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187541
NZ_CP036352.1\|WP_145125715.1\|1699444_1701784_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
NZ_CP036352.1\|WP_145125702.1\|1685364_1686303_-\|DUF4198-domain-containing-protein	unknown	unknown	gnl\|CDD\|378467
NZ_CP036352.1\|WP_145125709.1\|1695177_1696248_+\|AAA-domain-containing-protein	unknown	unknown	gnl\|CDD\|285027
NZ_CP036352.1\|WP_145129760.1\|1678581_1679265_-\|choice-of-anchor-E-domain-containing-protein	unknown	unknown	gnl\|CDD\|380209
NZ_CP036352.1\|WP_145125685.1\|1674433_1675306_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|277316

Protein	Function_ID	Function_description	E-value
NZ_CP036352.1\|WP_145125689.1\|1676492_1677194_-\|PTS-transporter-subunit-EIIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	1.99749e-24
NZ_CP036352.1\|WP_145125721.1\|1706110_1707178_+\|terpene-cyclase/mutase-family-protein	gnl\|CDD\|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	3.06582e-17
NZ_CP036352.1\|WP_145125717.1\|1701795_1705368_+\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000639234
NZ_CP036352.1\|WP_145125700.1\|1682676_1685361_+\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NZ_CP036352.1\|WP_145125711.1\|1696350_1697274_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.11618e-23
NZ_CP036352.1\|WP_145125696.1\|1680618_1681275_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	9.95538e-33
NZ_CP036352.1\|WP_145125692.1\|1677298_1678486_-\|hypothetical-protein	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	3.21475e-73
NZ_CP036352.1\|WP_145125713.1\|1697315_1699448_+\|VWA-domain-containing-protein	gnl\|CDD\|131281	TIGR02226, hypothetical_protein-transmembrane_prediction, N-terminal double-transmembrane domain. This model represents a prokaryotic N-terminal region of about 80 amino acids. The predicted membrane topology by TMHMM puts the N-terminus outside and spans the membrane twice, with a cytosolic region of about 25 amino acids between the two transmembrane regions. Member proteins tend to be between 600 and 1000 amino acids in length. [Hypothetical proteins, Domain].	1.32537e-16
NZ_CP036352.1\|WP_145125706.1\|1693283_1693661_-\|DUF486-family-DMT-transporter	gnl\|CDD\|377316	pfam04342, DMT_6, Putative member of DMT superfamily (DUF486). This family contains several proteins of uncharacterized function. The family is represented in the Transport classification database as 2.A.7.34, though the exact nature of what is transported is not known.	1.21258e-59
NZ_CP036352.1\|WP_145125723.1\|1707210_1708452_+\|hypothetical-protein	gnl\|CDD\|377970	pfam08305, NPCBM, NPCBM/NEW2 domain. This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.).	6.26671e-11
NZ_CP036352.1\|WP_145125687.1\|1675302_1676295_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.69995e-57
NZ_CP036352.1\|WP_145129760.1\|1678581_1679265_-\|choice-of-anchor-E-domain-containing-protein	gnl\|CDD\|380209	NF033208, choice_anch_E, choice-of-anchor E domain-containing protein. This HMM describes a domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, usually PEP-CTERM but occasionally a type IX secrection (T9SS) recognition domain.	4.09675e-17
NZ_CP036352.1\|WP_145125708.1\|1693835_1694810_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187541	cd05230, UGD_SDR_e, UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs. UGD catalyzes the formation of UDP-xylose from UDP-glucuronate; it is an extended-SDR, and has the characteristic glycine-rich NAD-binding pattern, TGXXGXXG, and active site tetrad. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.06547e-91
NZ_CP036352.1\|WP_145125715.1\|1699444_1701784_+\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	5.82108e-06
NZ_CP036352.1\|WP_145125702.1\|1685364_1686303_-\|DUF4198-domain-containing-protein	gnl\|CDD\|378467	pfam10670, DUF4198, Domain of unknown function (DUF4198). This family was previously missannotated in Pfam as NikM.	4.48716e-26
NZ_CP036352.1\|WP_145125709.1\|1695177_1696248_+\|AAA-domain-containing-protein	gnl\|CDD\|285027	pfam07726, AAA_3, ATPase family associated with various cellular activities (AAA). This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.	2.12395e-89
NZ_CP036352.1\|WP_145125698.1\|1681516_1682527_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.52209e-24
NZ_CP036352.1\|WP_145125685.1\|1674433_1675306_-\|hypothetical-protein	gnl\|CDD\|277316	cd00144, MPP_PPP_family, phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain. The PPP (phosphoprotein phosphatase) family is one of two known protein phosphatase families specific for serine and threonine. This family includes: PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6, PP7, Bsu1, RdgC, PrpE, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes. PPPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.55587e-05

>NZ_CP036352.1|WP_145125702.1|1685364_1686303_-|DUF4198-domain-containing-protein
MRTNREVFQGKPMNRSLYPRRAASCMVALTGILCGRAAAHEYWIQPATFQPTAGREIDVNLFVGDGLPGEPRPRDNSRLIRFDSYFQLSNAVANSRTTDISGDDGGTPAGRFVFTSNGLNTLTFCNRPTTITLEPDKFEAYLREDGMEHVIDLRKKLGESTKPGREAYSRCAKALVAVNGDGRGVHDVRIGLPLEIIPLNNPYRPLEKRRRSPATTQPTTINAPSQPSAPTRMTFQLVENGRPAAGALMAAIWLENGKSVRRTARTDSDGKASFELSQPGMHVINAVRMTRARGRDDVDWESTWSSLTFELP
>NZ_CP036352.1|WP_145125700.1|1682676_1685361_+|phosphoenolpyruvate-carboxylase
MSDELHRDLGMLSAILTSVLDRLGPPGQTQAVEGMLELCRRGETIGFGEAREQVAALDLESIRELIKSITLRFHLRNQAEKVAILRINRRRQREATEFQPRRESVAEAISQLKARGVAVGAVRRILDRLDIQPTLTAHPTESRRRTLLRKQRAITERLIELDEVGPDVAARRRVEEEIHQLVMLLYVTDEVRSERLGVLEEIEGSLYFLTESIWSAVPRILHDVGLAMEQYFGERPLVPPLVRYRTWVGGDRDGNPLVSAGMTRESLRLHRRAALGRYDDKLADLMRLLSLSNRRVRTPPALAASVVPGRLTGWVAEESVLRLRHEPFRLKILEMRSRLVAAEEDPSAYSAAAFLKDLTLLAESLVALNLGEIVRASGLADVMAQARIFGFHFAALDIRQHSAVHEQVVGELLSAMQVCPDYASLEESERSGVLASAIEQVSACGSGPMPTPDGLSETSLDLLGVFEVLREAARQDVGALGSYIISMAHGVSDVLEVLFLMRVAGAPVMDIVPLFETIDDLTASADLLAAMLIDPVYRAHVESRGRFQEIMLGYSDSNKDGGYVMSSWLLHTAQSRLARVCREHGVEFRFFHGRGGTVGRGGGRSNRAILATPPDSRSGRIRMTEQGEVISFRYTLADIAHRHLEQLTHAMILAESESGPVATARPVASEPLMDRLGRRAMEVYRELIDDPAFWTWFVEVSPIAQISALPIASRPVSRASGAVHFENLRAIPWVFSWTQMRFNVPGWYGLGSALSEIIAEREEHASTLAKWYQEWEFFRTLIDNAQQEMARARLPIAQCYDAAGGTSLFDRISGEFDRAREAILQITGQHALLDNNRVIQRSIEERNGATDVLNLLQVELLRRFREGDELQRATLRPVLFASINGIAAAMQSTG
>NZ_CP036352.1|WP_145125698.1|1681516_1682527_-|methyltransferase-domain-containing-protein
MHGATIASKTSPAAKPATPMHPTTPRIPGALNQSVHGYHCAACESNNSLSLPALRRGPACPFDLFRCRVCGMVQQQPRYSADELARLYSGDYYVFDEDDAHRAARAAQQYAVHLAPIEHLPSRRLLDVGCALGHFSALARDRGWQVVGLDVSADAARRATERFGIKVFIGTLEEHAESLSPFDAVFLGDVIEHVPHPLHFLRDVRRVLAPSGIVCIDTPNWGGFWRRWGGRHWLGLNRFHINLFDASSLANLLTSAGFTNIVAGSYTHHRYTRLASRPEIAALIARLSRALAWRVNRLLTGRSRRDANGPAPSTVARFQPRADLRGDNLIARAKTP
>NZ_CP036352.1|WP_145125696.1|1680618_1681275_-|sigma-70-family-RNA-polymerase-sigma-factor
MELQLRLTGTEIPQGRDLAAGDAPSCADSAHDDADLVRRARTDRQAFALFYRRHYAVMASYILRRVGDVHLTEDLTAETFLAVLKYLPRYRDRGLPIRAWLYRIAANTVNRWVRRERKRIVQSLAVLEAAESSNRTAGMPGSRHDNVRGDGEHARLVLLTLPPKYQAVLTLHYLEGLSLDEVAAALGCRLGTVKSRLSRGRDALRERLTRQNRARSRP
>NZ_CP036352.1|WP_145125694.1|1679654_1680539_-|hypothetical-protein
MTNEHDPIQSALESLKNRSWTGEPFDPQLEERLMKDFNTQTQFRRTPMRVAALVALSIVLVGGGAFAATGGIEKIRSWVFSVNINGQQAKLIANDGEPATMTIQGDDGKTTTISVLKATDAAQGDKTHVTVNATGPGSEDEQVVKMVRRQGPAPEEANASYTMDDIGDARATQTWTDKAGLTNSLYVIPSEDGEWIRVFRVTTDGAGSTSVQKLAQVPSMEGFEGITPQVSTDDSGVTTLVFDNGNGEKRVLKTRMATVADGENPENPNNIQIRTEDGRIQVDVEANSADDDQN
>NZ_CP036352.1|WP_145129760.1|1678581_1679265_-|choice-of-anchor-E-domain-containing-protein
MRPYRYKLLIATGLSLIAMTAAPSRADFQQVLPPAVVPLQLTNWNQFVTIPKFDPTLGTLTLVTVKISASFEASIVAENTGPSPSNINGVATVTVTPTPTPPVVWSLGPMAGGLASAAFVAPNDGTMNFTGPDTTNFDTSGTLMVTRNFNNPGDLVHFTAGFIGDNWTVNATGTGMVSVVSDSGNVHSQGQSKAGMQVDVTYHYIPEPTTLAFLALGLGVMTRRRKR
>NZ_CP036352.1|WP_145125692.1|1677298_1678486_-|hypothetical-protein
MGPGVSNTPHTLITRDGELNALCARLAKAESFAFDTEFVGEDQYEPEICLVQVATDEECALIDPQSGVDLTDFWQLIGDANICKIVHAGSEDIAICRRLGRCDPRNVFDLQIAAGMIGLGYPASLAKLAKAIAGVAMHKSQTLTNWRKRPLTAEQLDYAAADVAFLPRMHATICQRLRNRKREEWAIEESQRMCANAVRIVEPDDQRRRLKGAGSLSRRELAVVDALLAERDAIARERNRPPRTVLKDFLVIELARRGWTEPSKLATLRGMSLPQALLRRLGSAIERARNTPPENHPPALPSREHSEEEEIILSLLTGILRDHCRQNALAYSLLTTRNDLKDYARSVISGAGPTPVQLRTGWRHKAVGKLLDALLSGRSTVRIRPENGEFHVHIE
>NZ_CP036352.1|WP_145125689.1|1676492_1677194_-|PTS-transporter-subunit-EIIA
MPRAIMTVQQVAQALHVSTREVVRMAEQRILPGLRVKDRWEFRAGEVWNWIEKNIESLPRRRERDPHPAAPADLLLTHVLTPRTVRLDASPKTKSAVLRALAELAADCDPTIDVAHLTDELAQREQVSSTALERGVAVPHPCKPIYLEQPVLAVMRTSRGLAFGERAGGLTDLFFLVCAPDHVSHLLYLGRLCRLLIDARIIEDLRAAEHADDFIALLTSAEHRLCRTADIQR
>NZ_CP036352.1|WP_145125687.1|1675302_1676295_-|protein-kinase
MADILPGYNVVTKLGDGARSAVYEVIHVATGKLYTLKRVTREAHEDDRFLQQAINEFSVSQRLNHSTLRRSLELFKTRRLFKLVQVRVLMEFVDGLSLDRRRPERLDDLLRLFIQIAEGLGAMHQAGILHTDIKPTNVIISADGSVKIIDFGQSCPIGHRKPRIQGTPDYIAPEQVERRSLTQQTDVFNLGATLYWALTGQTFPTLITRHGRTRGTQTSSNKPPPAPIDLEPTLPPALSRLVMACCAYDRAVRPKDMAEIAGRLAPLLPAAQRHADQACRENPEPTASADVSTATPVLPPTSDDSLDYSAISEIINPHTTERRSGPETTP
>NZ_CP036352.1|WP_145125685.1|1674433_1675306_-|hypothetical-protein
MSMFAPQTDAPAAIDAFLQAAALNREDPFRQGGIIALPGYGQCVMTGDLHGNRKNFDKLTHYAMLDRASARHVILHELVHAELNTRELDRSHELALAAARYKCQFPEQVHFLQSNHELAQLTGYPIAKNGRAVIDEFNRSVAAAYGDARATDVLSALNEFIASFALAVRTENRVWMTHSLPNAHDMADFDYSIFERAPTREALASDRSIFNLVWGRRHSHEQLDALAAKLDVDVFMTGHQPQEMGYVLLFDRLIILASEHNHGSFLPFDLSRPLSADALIRNIRKFVAIV
>NZ_CP036352.1|WP_145125706.1|1693283_1693661_-|DUF486-family-DMT-transporter
MPVIVQSILLLTISNVFMTFAWYAHLKELNHKPWIVAAIISWGVALLEYLFQVPANRIGHQVYNVGQLKILQEVITLSVFVPFAVFYLRESIKLDYLWAGLCLCGAVYFVFRGSGNPTAVASISP
>NZ_CP036352.1|WP_145125708.1|1693835_1694810_-|NAD-dependent-epimerase/dehydratase-family-protein
MRILITGGAGFIGSHLTDRLLADGHEVIALDNLSTGNARNIEAARSNPRLRFVHDDVRSEHTLHVLTEQCDMVYHLAAAVGVQLIVDEPVHTIETNIHGSEVVLAIANKFRKPVLIASTSEVYGKSEKVPFREDDDTVLGATRYSRWSYACSKAIDEFLGLAYHQQYGLPVVVARFFNTVGPRQTGRYGMVIPRFVESAIKNEPIHIYGTGKQSRCFGFVGDVVDAIVKLMNNPKAAGRVYNVGATEEVSIEGLADKIIAMTGSKSTKKFLSYEEAYGRPFDDMMRRIPCLDRIREMTGYEPKANLEKILQLVIAEKKEQLARG
>NZ_CP036352.1|WP_145125709.1|1695177_1696248_+|AAA-domain-containing-protein
MRQDGAVTPESAQREREAIAALASSRDLIRAELSKVIVGQEEVIDQILICLFSGGHCILEGVPGLAKTLMIKSLARTLSLSFNRIQFTPDLMPSDITGTEIIEENKATGVRQLRFVNGPVFANVILADEINRTPPKTQAALLEAMQEHQVTAAGFTHRLPEPFFVLATQNPIEQEGTYPLPEAQLDRFMFKILMEYPSAADELRIISKTTTIETVEMKRVFTAEDLLALQEVVTRVPCAEHVMEYAMRLARGSRPQSPDAPEFVRRYVSWGAGPRASQYLVMGGKARAILSGRYHVSTDDIRAAAHPVMRHRIVTNFTAEADGVTPDGVIDRLLESVMGASTPDLDAIDAQRVLVK
>NZ_CP036352.1|WP_145125711.1|1696350_1697274_+|DUF58-domain-containing-protein
MIAQGENLQKYLNPAVLAGIAGLDLRARRMVEGFVSGLHRSPLHGFSIEFAEYRKYAQGDDLRHLDWKVFGRTDKHYIKEYEQETNLRLLIAVDASESMKYKSREAVWSKREFAITAAAGLSYLALHQADSVALATFDTRLHRHGRASNQPNQWKQIVAELEHRPAAGPTALRAVFDEMAESLRERHLIILLSDLLGDPDDIITGIKHLRHCRHEPIVLQILDHAELTFPFEGPVRFIGMEGVGPLATDPGALRDRYLAEITRHLDTIRRGCHAQQCDYQLMDTGAPLTTALSTYLANRAARVRRRS
>NZ_CP036352.1|WP_145125713.1|1697315_1699448_+|VWA-domain-containing-protein
MSFVHGGMAMAAAGLAMVPVLIHLLNRRRYRDEPWAAMQFILSAVQRTRRRLRTEQWILLAVRTLVMALVGLVVARPYFAPRSELLAVGEKRIDRVLVLDDSLSMRAGTMMHSSALERAKSAMLKLMDRSGGSGGFAVVTASRPVRAWFDQPVQDRLAVRQVVEGIEGTHAVSDLNGAVELADAILARGTAPAEACELYVFSDFCGRDLGRSVEESRSAIGPVENAARVVLIQTAAESRPNRAITDLRVVGQPALLNGAAEVLAEITNFSSGDTPATALTLRAGKHELGQRSIPSLAAGARTSVTFHVRLEPGRVHALEATLDRWEGDWLQEDDHRRLAVEVPNRRRVLLVQNRGTESAQEEPLFHFRLTLDGADATSTDQSPFYTTQVAADQFRDVVLKDYDVVAVGEWAHLGREALERLREFVAQGGGLIAFCGELEGADVDDLGELLPIRLLDIHREADDQPPPTLTVSDPAHPMLGDFAGQQRNILGRAHVNTWRRIENGTNGPRREPVLMTSTGDPILLLTEIGMGRMAIWLTSADMSWTNLPAKPDYLPLMMNLTGFVAGDRNSGRNVKVGESLWGRMLFSESERIELIRPDGKRQRAGHGVDGWTGRWRLNDTALPGIYEWSRGSSQEYFCVNADTAESDLRRVEESRVASSLGDRVAIVDSTELEAFAGSADVRELGWALAVILLLAATTESLLGRWFGGAR
>NZ_CP036352.1|WP_145125715.1|1699444_1701784_+|VWA-domain-containing-protein
MKRLAEWLLNLEAAGLTGGDSLALRFATPPAAWIMLIGAILSFVYVYRIYRAEPIPRQWKAALVTLRVGAVLTVLFILSRPMLVRRITHEQRGHVAILVDRSLSMASADGDWPAAKLPSGERPESNRLAVAHRLILNSGGRLGDLQNGYELSTWAFAESVTRLEAATPLLPTNANERVTDLAGAIGEVLNQESTARLASVILISDGRQSATNSIDDALAQAQARRVPIHTIGVGSWEPERDLRVDSVWHDNEVFVQDSVTLRVQVDARGLEAPQETAVELRDVESGALLSSYRGELSPSQRIASWDLIYRPTDKGRKSLEVRVLPISGERDLSNNAMVVSIRAHERKIRVLYVEGYPRYEYRFLKNLLVRDPTLESSCLLLSAASGFAQEGQRPQNRFPATSEELRNFDVILLGDVDLRREDAVSSAQQEWLVEFVSSLGGGVAFLAGTDHMPQVLRQTTLEKLVPVALDTQSRPGQQRLDDPRLVQITAEGDESGLFHFADDRAVRKEIGSAMPGWYYVARVLGAQPGASVLAAVPGGAGSAGLTPAIVMGRYGAGRTLFVGTDDLWRWREFGGDAHYETFWLGAIRALARGRMLGSDRSWRLETDRKRYDLGEPVQVRLMLRDASMRYLTGDMNIIVRDARGAVDRVALQPKVPGSGIWEGTWDASVSGPLTLDVASDAFSGDVEPPNCSLEVQAVDPEQRDTSADRRLLARIAQETGGRAFWATDDLSKLAESIPDRSVITPADIETPLWDTRLIVLALAGLLTTEWVLRRALSLP
>NZ_CP036352.1|WP_145125717.1|1701795_1705368_+|hypothetical-protein
MEPRKPPTEQLLARLAAVRRRIRWLLALEAVGKILVAGVAYAAVVAAADWWVHFPGYVRLIFNATFVIIIIRYAWQRVYRPATAPIHLDQVALVLPDLPSELRDRLAASVAYLDHGGTGSSTLWHRVIEQTSDSLGGARLARGLRPARARRWMTAGVLGLVALGSIAMWQSALARVGFARLAIPLGESAWPRRVEILPLTGDAVVAAGESFEVAMRVARGESRLHRVYLNLHPIHGRVQREVLRRGPDGVYRRTLDAIRSDVKYSFTCGDHDLSDSPFTLRCTARPELVALSADVSLPTYAGSSQAETQSGRDDGFHAIRGGSLLLRATCHLPTADQLTGAIVALVFDDGRRLEMQRGEGAEWTARMEALESVSFAVELRDGLGLTPHERRVTRLTVRPDQPPAVRIASPIGLLDVTPRAELDVIVHAEDDVELAGVSLVATVERAASESQPSKWAVDVLKEGIDLKSDLGADAIADSRSAVIGAAAPSAPEKAMERLYRWSLAGMHLQPGDTVVYHVEARDAFTQQDSSRVVRTLPQRLNALSPAELARRLREELLLTQRPLRRLVADLTSIEGRTRALESAGATSQSAQPQDRHPARLLAAELQRVRQSAGPILDRMSTVIDRGYVNRLGHEDVIQLSRRLHGELTEVSEEMLVRAVEALEPLKGNEESLRMAAAVDYEGRAIAGIHAILDRLANWNDYEELVQRVREMQARQEALIRIVADADRSAQDARIDTLGGSGTEAPGRSAGAPREMEAAAQDQRQLSAEATRVLVSMKDYGRESEVVANARAAALRAAADLGYRHNIVGRMDDAVTELVAGRAGLAGDAQAGAAAGLQAMIAMLEEAPQRELSLLSRALSDAAERLKKIISAQRDLIARAQAADQEGSRLATRQSTLARTTSAFSSGLKVADTDAEVVQEQTAKSSEEMLTAAERLTASDRSQAGERQNAALELLETALSILERRRQEADQAAAEKSLAALTGQLVAIYREQGLILTDTQTLASRSAESEQLSRAEVLRAGQLAVRQSASKDQMAEAKEKMSGSIVFSHVAARITLGMEESGALLNTREWGGAVVVQEQVLAELKQLIGAIEELPRPDSSKQFADAAGAGQSAAQPTMQRLIPPLAELKVLRSMQSAIHDQTVRHAATASATGEDAARRSELLRSMGASQRELHELATKLIEQAAADGGSP
>NZ_CP036352.1|WP_145125719.1|1705364_1706114_+|hypothetical-protein
MTKMCGAEQVAGSRARGAAVATMVAGLSVFMASSFASDPMGTPSETTTSATSTQSADADKSATTQPGVSPRDQMVRKLLDGESTAVDQVDLMLASMGEASERLNSKSDAGSQTQAAQRRALEGLDTLIRQAGENRRAAPQASRVRPRGEREGQRRRPPGERKQMNQGKGGQAQRGGPGAEGGAGADSSRKQAAKAELARGWGFLPGRERDEVLQGFDEEFLAKYREQIMDYYRRLADAAVAKASSSDKR
>NZ_CP036352.1|WP_145125721.1|1706110_1707178_+|terpene-cyclase/mutase-family-protein
MTSRRIIAMTLGCATSLAFVAARPSVCGAQWPASQPAATAKRDGRVDRPTPEQSAAIERGLKWLAEQQKPDGSFGSGSQYGRHVGITSLACLAFMSEGSMPERGRYSKNVDLGLEFVLKACSDQSGLIAAETSYGPMYGHGFATLFLAEAYGMSHRGDLREKLQKAVALIVRTQNDQGGWRYHPVKADADISVTICQVMALRAARNAGITVPKEVIDKSIKYVRESQNPDGGFRYMLDSAGSMFARSAAGVAALYYAGMYDDPVIRKGLGYLKKFTPGKTEEQTHYYYGHYYAVQAMHVAGGEHWEQWWPAIRDELLVKQLPDGSWRGEAGTEYGTAMALIVLQVPRGNLPILQR
>NZ_CP036352.1|WP_145125723.1|1707210_1708452_+|hypothetical-protein
MQRLIREHSWRSSGLGALLALCTVSSTARGQPVTAYPIEDKALKGALVSFAIPGDVVLEHEGEKSTISWNDLDRLALNVRGEAVTEAWRLTLADGGVLFGRIAGGSEIAVRVEHAILGALTIPFEQVQVIERRSAAGETGDGSRASGSRDRVEDRLILINGDVLKGSIARLTSEGVAIVSGERERLVAWGAIRRVILAPMPSSAGPGVAGATSRGANETKAQFQLVDGSTLAARGATLRGASIQVDSGLGFVMAMPPDAIRTIESVGGRRAWLSDMPASDSREIRYFDHSIPSDMAAFGRAEPIRLDGAAHGRGLRFAGAGKRSWKLQGQFVLLRASLGMEDGTGPLADADVVIRVDGRPVIEHRGLRSGQPARSVEINLAGANELEIDVGFGRRGPVQDCVVLVNPALIKRP

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Crispr_ID: NZ_CP036352_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036352_4

1897077-1897175

Orphan

Consensus_repeat	Method
GCCAAAGAGCCGCGGGCTTCAGCCCGCGCGGCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP036352_4

>merge|NZ_CP036352|4|1897077-1897175|CRISPRCasFinder
GCCAAAGAGCCGCGGGCTTCAGCCCGCGCGGCGCCGACTACTTCCGATACACGTTTAATTTCGCCAAACGAGCCGCGGGCTTCAGCCCGCGCGGCGCCG

>NZ_CP036352|4|2|1897077-1897175|CRISPRCasFinder
GCCAAAGAGCCGCGGGCTTCAGCCCGCGCGGCGCCG	ACTACTTCCGATACACGTTTAATTTCG
CCAAACGAGCCGCGGGCTTCAGCCCGCGCGGCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036352.1\|WP_145126032.1\|1900776_1901046_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145126044.1\|1906395_1907199_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP036352.1\|WP_145126015.1\|1889234_1890215_-\|DUF47-family-protein	unknown	unknown	gnl\|CDD\|224310
NZ_CP036352.1\|WP_145126030.1\|1898875_1900711_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|379140
NZ_CP036352.1\|WP_145126017.1\|1890323_1891034_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP036352.1\|WP_145126046.1\|1907249_1908668_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|183211
NZ_CP036352.1\|WP_145126009.1\|1885479_1886781_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224423
NZ_CP036352.1\|WP_145126026.1\|1895147_1896095_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|372253
NZ_CP036352.1\|WP_145126048.1\|1908745_1909549_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176209
NZ_CP036352.1\|WP_145126038.1\|1903922_1904576_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187677
NZ_CP036352.1\|WP_145126011.1\|1886799_1888107_-\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|379040
NZ_CP036352.1\|WP_145126034.1\|1901505_1902420_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275056
NZ_CP036352.1\|WP_145126042.1\|1905166_1906396_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|182528
NZ_CP036352.1\|WP_145126036.1\|1902865_1903918_+\|MreB/Mrl-family-cell-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562
NZ_CP036352.1\|WP_145126024.1\|1894371_1895283_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP036352.1\|WP_145126040.1\|1904660_1905116_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145126013.1\|1888239_1889196_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|275035
NZ_CP036352.1\|WP_145126018.1\|1891124_1892915_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|274368
NZ_CP036352.1\|WP_145126020.1\|1892980_1893499_+\|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein	unknown	unknown	gnl\|CDD\|238451
NZ_CP036352.1\|WP_145126022.1\|1893495_1894338_+\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777

Protein	Function_ID	Function_description	E-value
NZ_CP036352.1\|WP_145126044.1\|1906395_1907199_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.53299e-112
NZ_CP036352.1\|WP_145126015.1\|1889234_1890215_-\|DUF47-family-protein	gnl\|CDD\|224310	COG1392, COG1392, Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism].	8.14849e-28
NZ_CP036352.1\|WP_145126030.1\|1898875_1900711_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	7.76692e-15
NZ_CP036352.1\|WP_145126017.1\|1890323_1891034_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.59101e-74
NZ_CP036352.1\|WP_145126046.1\|1907249_1908668_-\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|183211	PRK11578, PRK11578, macrolide transporter subunit MacA; Provisional.	1.17456e-27
NZ_CP036352.1\|WP_145126009.1\|1885479_1886781_-\|hypothetical-protein	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	3.6656e-09
NZ_CP036352.1\|WP_145126026.1\|1895147_1896095_+\|ABC-transporter-permease-subunit	gnl\|CDD\|372253	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family.	1.71944e-09
NZ_CP036352.1\|WP_145126048.1\|1908745_1909549_-\|hypothetical-protein	gnl\|CDD\|176209	cd08247, AST1_like, AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast. This group contains members identified in targeting of yeast membrane proteins ATPase. AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast, identified as a multicopy suppressor of pma1 mutants which cause temperature sensitive growth arrest due to the inability of ATPase to target to the cell surface. This family is homologous to the medium chain family of dehydrogenases and reductases. Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of an beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	0.00225533
NZ_CP036352.1\|WP_145126038.1\|1903922_1904576_-\|hypothetical-protein	gnl\|CDD\|187677	cd09619, CBM9_like_4, DOMON-like type 9 carbohydrate binding module. Family 9 carbohydrate-binding modules (CBM9) play a role in the microbial degradation of cellulose and hemicellulose (materials found in plants). The domain has previously been called cellulose-binding domain. The polysaccharide binding sites of CBMs with available 3D structure have been found to be either flat surfaces with interactions formed by predominantly aromatic residues (tryptophan and tyrosine), or extended shallow grooves. CBM9 domains found in this uncharacterized heterogeneous subfamily are often located at the C-terminus of longer proteins and may co-occur with various other domains.	5.11386e-05
NZ_CP036352.1\|WP_145126011.1\|1886799_1888107_-\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|379040	pfam13145, Rotamase_2, PPIC-type PPIASE domain.	1.47118e-10
NZ_CP036352.1\|WP_145126034.1\|1901505_1902420_+\|hypothetical-protein	gnl\|CDD\|275056	TIGR04211, hypothetical_protein, SH3 domain protein. Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.	1.68353e-05
NZ_CP036352.1\|WP_145126042.1\|1905166_1906396_-\|FtsX-like-permease-family-protein	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	4.31021e-46
NZ_CP036352.1\|WP_145126036.1\|1902865_1903918_+\|MreB/Mrl-family-cell-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
NZ_CP036352.1\|WP_145126024.1\|1894371_1895283_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.16388e-88
NZ_CP036352.1\|WP_145126013.1\|1888239_1889196_+\|glycosyltransferase	gnl\|CDD\|275035	TIGR04182, glyco_TIGR04182, glycosyltransferase, TIGR04182 family. Members of this family are glycosyltransferases restricted to the archaea. All but two members are from species with the PGF-CTERM/archaeosortase A system, a proposed maturation system for exported, glycosylated proteins as are found often in S-layers.	2.5412e-73
NZ_CP036352.1\|WP_145126018.1\|1891124_1892915_+\|HAMP-domain-containing-protein	gnl\|CDD\|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	1.7096e-67
NZ_CP036352.1\|WP_145126020.1\|1892980_1893499_+\|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein	gnl\|CDD\|238451	cd00886, MogA_MoaB, MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.	4.94614e-61
NZ_CP036352.1\|WP_145126022.1\|1893495_1894338_+\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	6.43481e-33

>NZ_CP036352.1|WP_145126026.1|1895147_1896095_+|ABC-transporter-permease-subunit
MRKLDGTGGGIASLAGNTGPGRCHDRRAGPGGFVCDVLRGGPARMISLPLTGKTLRGYAVVIVGAHLLLCAFAALYMVVTASVPIERSLEMLNLEWVRSLLTALLGSDVGSQFTPNGITAFFFVHPLMWTLVVATLITISTGVMAGEVDRGTMDLLASLPISRARQYGSHSLVLVALGAPFIVAILVGIRLGLAIKPQKEIEFWRLAIVAGHLYVVYVTLSACCLAVSAMCNRRGVAAGICFVAIFYCFVINFLAELWGPAKRISWTSFLHYYRPLPIVRAGAWQVRELAILLSVATAFWAGGLMAWTRRDIPAR
>NZ_CP036352.1|WP_145126024.1|1894371_1895283_+|ATP-binding-cassette-domain-containing-protein
MSSASTAASTIEVHDLVKSYGAIRAVAGVNLRVEAGAIFGFLGPNGAGKTTTIRILLGLLRATGGSARVLGLDAWRQSTELRRQVGYLPGDVRFYDWMRGNTFVNFCNQARGGGCEAEIRRLCDRFQLDLSRRIRDYSRGMKQKLGVIQALMHRPQVLILDEPTTALDPLVQQTVYEELRAAAGEGRTVLFSSHTLSEVELLCDRVAIIRAGRIIEDSTIDALRRRALRRVELRLKQGGLSESRAPKGFTPRPSADGATCGSWTGPVEELLRWLATLDLADVTIGAPDLEDLFATYYEEAPRA
>NZ_CP036352.1|WP_145126022.1|1893495_1894338_+|rhomboid-family-intramembrane-serine-protease
MIPIRDDNPTAGTPVVTIALIVINVLVFFAELGQGQRMQEFIWKYGYVPAELTESRADLRRAMVDEAPVQPATDQFGNQIFDPFGRPLGRRVPLPFDEAIALPAWLNIFTCMFLHGGWGHLLGNMLYLWIFGNNIEDRLGSALFLVFYLATGLVGNLAHTLFDSGVVPLVGASGAISGLMGGYLLLFPHARVLALVPAGWYWFTVKLPAWVFLGFYVVLQNAFPALGGFVSSGSEGSAVAYLAHLGGFVGGMAFIHLFPHRPASHRARREISDEDADLVI
>NZ_CP036352.1|WP_145126020.1|1892980_1893499_+|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein
MFKAAVVTISDSRSAGSKEDRSGPAAAELVAALGVEVVERRMTADEADQIADCVRSLVGRVNLIVTTGGTGIGPRDVTPEAIVPMLDRELPGFGEIMRTGGYSKTPMFDRTPLSIMTRGGAGIIGHTLVVMLPGSVNGVRSGLDLIGPAIRHALGILNRTVTDCSATAQGHE
>NZ_CP036352.1|WP_145126018.1|1891124_1892915_+|HAMP-domain-containing-protein
MPRITEMHWQGRFFKRVFSRLGALLCVGMLLVCAVTWQIMHRWLAGYTQDQIINQAHLTKLVIERQWPLDGEALQRECDLMHELTLLRLTVMSPDGRVIADSNANPTEMENHSKRPEVVAALAGRIGQDLRKSSSVGEDFVYIAMPLVHEGRLAAVVRAAAPAADLKRREEALVKWITIGLAIAIPLALLGAWVLSKALARPVQRISVLARRLSTGDLQDRVEVGGDDEIWQVAESLETMRENLLARVREVQQQRMDLEVTVSHLEEGIITVDRAGLVLTANDAARRLLAVDSPLLGRLLSEQISNEALRDMWTEALAAGRPELRRELKRSKVPGAAQLSVTIIRVTEPSTPIAWLICIRDITALARSAAMKTDFVANASHELRTPVASIRAAVETLNADGLDREMTRRFMSVIARNVERLQNLTEDLMDLNRVESESPDLSVRRFRPDEVFASIRSVFAEALRQKSVRLEFSNEVEELETDPRWLELVLKNLVDNAVKFVGIGGRIEIRCRHEGDMARLDVEDNGCGIPKADLERVFERFYQVDKSRRVGIGGTGLGLAIVKHAVLGMGGEVSIASEEGRFTRVSFTVPVAAVPV
>NZ_CP036352.1|WP_145126017.1|1890323_1891034_+|response-regulator
MTQSRVLVVDDERDLVELICFNLKRNQMTPISCHDGNTALELARREKPDLIILDLMLPQRNGREVASMLRADSATRQIPIIMLTALTAEHDIVTGLQIGADDYVTKPFSMEVLMARVAAVLRRRAGVAKDDTVLRAGAVTLDRARHVVEVDGQPVAVTLTEFRLLEALISARSRVLSRDQLMAKVMGPDIAVTDRTIDVHITSLRRKLGSCRDLVETVRGVGYRFADVWQGEPVEC
>NZ_CP036352.1|WP_145126015.1|1889234_1890215_-|DUF47-family-protein
MALSAPAMTVKGLLTPAEQPEAFDAFRSIADSGPRFLRTAVHGFLIIGGLVFQWRATSAADRCYSDLRSIHMPCSQDLNGRFTCDQCRAKYDAGLSRSDRTSPRQPRHDASGANQEWDPVFTIIPRDTVFFDLFEQSADLVARAAVVYSELMADFPRRDDHIKRIRQAEHDNDEVVHKALARMDTVFITPFDREDIHLLLKNMDDVIDEIDASAKRLAIYKIDAPDKWLTKQSQLLVKSTALLRDAVNRLRDLKRPNGLQQKLVEIHLIENEGDENNHAAVAELFENASDPLRVIKMKEIYDFTERAIDSCEDTADIIEAIILKNT
>NZ_CP036352.1|WP_145126013.1|1888239_1889196_+|glycosyltransferase
MESANPGKPAGGGAGRIAVLVPCYNEAATIAKVVADFRRELPEATVYVFDNNSTDGTGDLARSAGAVVVHEKRQGKGFVVAAMLEKVDADFYVMADGDDTYPAERVRDMLSPVLTGQADMVVGRREAENEAAAYRRFHVFGNWLVRTMINLIFRARLTDIMSGYRAFTREVARSLPIMAYGFDIETEMTVQCLYRKWVLREVPIAYRERPEGSVSKLSTFRDGFRVIFRILSLFRSYKPLTFFGGMGIALMGLSLGCGAWVLFGEAGADSTRRTLFIVATFTLLAMSLIAASIGVIVQLINFRFLELDSVLRRNRGGR
>NZ_CP036352.1|WP_145126011.1|1886799_1888107_-|peptidyl-prolyl-cis-trans-isomerase
MSRYSTFAVLLILSVALGCTDRAGNRVSMEDWFRGRSADSPPQAPDATNSDAASSRAATPERSSLHDLPADATPAQQKKADRALAAEFANAAPAPPPGAVLPDVLVVDDERISVTDILEPIEQRLEDLARSLPASTYFEEAAKLVRSQIVEHVAQHLIWRRAKTHLTEEMEPQVDKAVAKMEKDRINREFGGRETLYEKYLSKHGRSRDDVKKRLRKVVLIDSYLRDRLLPQINSPRKQELMAYFNRHRAEFSRPERREMFLIDVPVNAFLDTRRWPTRQEQQEAEVKARAEIEAAQAALQRGETFEEVARTRSRGLHTETGGNWGLITKPIGEESALQGHWEAPSRRLFELQPGETSEIIHAANSFFIVRVGQIEPAEEMSFQQAQPKIVDTIRQERFIRLRTEFLQAELEKATIGSLEDFVTRVLRGVPRPAR
>NZ_CP036352.1|WP_145126009.1|1885479_1886781_-|hypothetical-protein
MDAHPADLAATIILTGLACVIRLVCNVPRRASPPSNPRSTLWEKRMASVPAANRIAWMMCLGLALAGRPAVADEKKPAAARPAPKGWNVAFVHNPKLPPMFRQVDARRADGSNLSIYLGDFDDGLASKKPLLVFVDGSGAHSQFMVRDGRVGYGLFGFIADRFKKEFHVATAEKRGIEFGYFPKEHIGSAEGAPEEYQQNATYEGRTGDVCLLLDTLLKQPNVDADRVVLMGMSEGADVAAHAAARDPRVTHVVFMSGGGPTQFFDLVTLRRKGMAKDGASPEEIDSAVREMEAEYRDIIAHPDAIDKFFAGHAYKRWATFCAHPPVESLARASAKIFLAHGTEDISVPIESFDFTVSDLIRRGRKDVTVHRYPGRDHSLGDPKAEQKGPPMVDVIDEAVAWTANASGKSTTAKREAKGSPERENKSVRKRGE
>NZ_CP036352.1|WP_145126030.1|1898875_1900711_-|PQQ-binding-like-beta-propeller-repeat-protein
MQKRDYSICQSLPRSATCLLAAFAFVVMLALPRSSAAQMVSDEALGRLDLRSAWSIDLPLEGGEEVTRTVAIDDNLYVLTSINRVYAVHLHTGILRWASDVSSTGDQVRGPTHSDNYAVFTTPGAVRMLDRRTGLIPGEPRHLAGVVVEIKHDTAEVNLGEVHGLKGGEILNVYMANEYGDREGDPVARIQLGVVENRYSKGRITSLNPSIKPLAGYKVEADLEMPLEEVKLPFAASSPAVANASHLFVGASNQRFYCVDIHRDVTHWQLLTPNTVTAAPILDGKSLLIAGQDGLVTCCTQAEKAKNWTFTTEGPIFASMVLDGDRLFVASSDRSLYCLHRLTGKRLWRERFDSQLNTAPNVSDGRVYLQVPDAGLYVLDATNGTQLWKRPQGGRFLLQLERDVILLSDDGAGAMVRVDAAKGTRKQVAELSGVRQATSSLAAQAILIASADGRVQSLRSRFAPRVRPEDVAEVLYDADKARAIAKVDADRKAAAEKKTVDQPKRPTARELMFDDDLLSSRSTAKPVGGHGLVEVGEEADQEKAATAPEEDEGSDESDGVSDSESEDTDMAADDADADETEDEESSDDEDEEESEDEEEDSDDEDSGVTGG
>NZ_CP036352.1|WP_145126032.1|1900776_1901046_-|hypothetical-protein
MAQPPASPQASPPNDLSPEDRMLVRLRDQLYGGNWGEMILDLQCRLRGEPYIFKLASRIQDDLDRIDRLRAVEQQRGAAPSESPSSRNA
>NZ_CP036352.1|WP_145126034.1|1901505_1902420_+|hypothetical-protein
MSVLTKVLVVLLTVSSIALSMLVVAAFSQQENWRQSATDWEATALAAQAKERAAVANAAIEQQRALAQSKTDSGKIAALQADLTAREAKVKELELAVADAQNKLSKEQSQVTSVADENKILLTGLNKEKDFAAKLAQRNSELERGNIDLTDRVKELTTSVDMARAQVRALQQQIASMDDAARSGAGGLTAATQIPGGGGIVEGGMPSVQPVAGQVVAVPIRGQVKSVKDNLASISIGSADGVVPGMTFLIYRRGGGEGGKPQYLGTLKVTRVTANESGGTIEQAEGDIRPGDLARDEASFAMRG
>NZ_CP036352.1|WP_145126036.1|1902865_1903918_+|MreB/Mrl-family-cell-shape-determining-protein
MLFDGFRGLFSTDMGIDLGTCNTLVCVKGEGIVLNEPSVVAVRKGTNEVVQDGNAVGLVAKEMLGKTPGSITAVRPLKDGVIADFDITEAMLGYFIRKVHGNSWFRRPRVVIAVPSGITAVEKRAVYGSAERAGARRVYLVPEPMAAGIGAGLPIAEARASMIVDIGGGTTEVAIMSLGDISVSESIRVAGDDLDEAIISYMKRTYNMQIGPQSAETLKIEIGSAAPLENELSLDVRGRDMISGLPRKTVVTSQEIREALREPVSQILEAVTHTLERCEPELAADLVDTGVHLCGGGALLRGLDRIMADATGLQVHIVDDPLSCVARGTYIFLENLGDLKGALESDYDNV
>NZ_CP036352.1|WP_145126038.1|1903922_1904576_-|hypothetical-protein
MSLIPNRYLFKFEFPLIRSAKAPKIDGRADRWDERLLLPPLYELDGEPPTGNVLATWNDAGLYIGCVVRGKRRGVRCDPAQFWKSDCLRIMTDMRDTRDIRRATRFCQHFYLLPAGGGRGGNDPVAGNAKVHRATENAAPIPASRIPIAAHHFDDGYALTAHLPADALSGWNPAEHRRIGLFYMLEDTEKGQQSLTIGDDLNWFIDPSTWPTAVLAD
>NZ_CP036352.1|WP_145126040.1|1904660_1905116_+|hypothetical-protein
MNRLFFLCVACCLFFSSGCNSLFRSKAVSERVWSLDTDTIVKVRCEREVDFLKPAQQRSRGVSFVSVESRDGLAREIQFDAETNNGACLFDLESMKICTDSHRRIIWLIGPDGQPLDEYIFIRAESQTGIPQNAPVPHYDPATAVILEPVS
>NZ_CP036352.1|WP_145126042.1|1905166_1906396_-|FtsX-like-permease-family-protein
MFALWIECLKMGLRELWRHKLRSFLTMIGMIMGVSVVIICVSVVQGVKESLIGDIRKAGRNMIFVINEETKKKNVQLETSGVAVSNLTRADVEAIQDECDAVTMACGTQGITTQVVSETDNAMVPVTGVNANYTSIRNWGIDEGRDLEPFDVATGRRVALIGQTAARNLFGERNALNQTVRVGRLSLKIVGVLASKGYNPLGMDEDETLIVPLPIVLRDLMGIREPAAILCSARSDEDVELAVQQITDLLRQRHKIPEEEMSDFRVTTLKEKEEQARQISDQMTLLMFFLALVSLAVGGVGIMNIMLVAVTERTREIGVRMAIGASTKAINRQFLVEASVISSAGGSVGIVIGLIGATLIATSIGVEPLMSPWIAVVAFVFSAGVGVGFGLLPARRAANLNPIEALRHD
>NZ_CP036352.1|WP_145126044.1|1906395_1907199_-|ATP-binding-cassette-domain-containing-protein
MPSQTPLPNQPKSTVDDPSVNVVIQLRALEKIYDSGDNAVHALRGLNVDIPEGQYIAIMGASGSGKSTLLNVLGALDVPTKGTYRLAGQITSNLDRDELATLRNTYIGFIFQNFNLLTRSTALENVELPMVYAGVQAARRRESALAALRRVDLAERIHHLPSQLSGGQQQRVAIARSLVNNPRIMLADEPTGNLDSHTSGEIMRLLTELHEREKRTIILVTHDPGVAEFAERVIVLRDGLIIADQKTPRIGGPPVPDVRALSAQGVA
>NZ_CP036352.1|WP_145126046.1|1907249_1908668_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MKRKSGIGFIVVFLVVAAAGFFGYQAYKGSGPSYEIEHAIVESGPVQMTVETSGTVEPLSQVQVGCEVTGKIIDMPVDHDQPVKKDQVICRIDQELADADHQQSTADLARGRSGLTDAKLALDELKANLPIATRQALAAKEEAEANLVDADYQWERVDELYKNDNAPKAEWIATKARLLRSQAAVHSTTAAHELAKLNETVKVKRAEQAISQAEATLKQAEARFELTKTRVERCTITSPIDGIVLKRYLDPGTTVNAAFQTPILFLLAPALDEMRVSAKVGESDISHIQVGQKARFTIEGRQRQTFEGVIEERRNQPDIINNVVTYTVGFRVKNDEERTLIPGLTVNVVIEIVSKPDVPRIANAALRFKPPLPIEDRQKLIAAAKWPDQPERDSTGAAADYCTKSFAWQFEEKSRTWRVVPLWVGVTDNIITEILSGAKPGENFVRRFTEKSGGGFDFKEVLKQARPDNRTL
>NZ_CP036352.1|WP_145126048.1|1908745_1909549_-|hypothetical-protein
MKHCLAAGIIGLIALTGCADPKEKFGKTWYIDGAGNWGFGVIDVPVGLEEAGYKGRVNNYQWSLTFNPALDQTLRFIAKGRGEVLGAIITDYLKRNPDADANIIALSAGTGVAMWAVESVKPPYKVNNVILVGSSLSCNYDTRKAQENMKGGIYVYYSASDPVLQGPVRVLGTIDGKFDDSAGLVGLRGAGKSSGRIHNIGWSSRYSSLGWTGGHADCTNKRFVKAEISKHIVRAARKPPSAVVKPEPAESKEPVQEEATLGNIGSR

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Crispr_ID: NZ_CP036352_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036352_5

2610724-2610966

Orphan

Consensus_repeat	Method
GCCGTCGCTGTCGGCGTC	CRT

4 spacers

The CRISPR arrays of NZ_CP036352_5

>merge|NZ_CP036352|5|2610724-2610966|CRT
GCCGTCGCTGTCGGCGTCGAGGTTGTCATCAAAGCCGTGGCAAACATCCACGTCGCCGCATACGCCGTCGGCGTCCAGGTCGTTGTCCGGATCATTCGGGCACTTATCGCAACCGTCGGGGATGCCGTCGCTGTCGGCGTCAATCGTGTCGTCTTCGCCCGGGCAGAGGTCGCTCGCGTCACACACGCCGTCGCTGTCGGCGTCTTCAAACGCGTTTGAGCAGACGCCGTCGGTGCAGGAGTC

>NZ_CP036352|5|1|2610724-2610966|CRT
GCCGTCGCTGTCGGCGTC	GAGGTTGTCATCAAAGCCGTGGCAAACATCCACGTCGCC
GCATACGCCGTCGGCGTC	CAGGTCGTTGTCCGGATCATTCGGGCACTTATCGCAACCGTCGGGGAT
GCCGTCGCTGTCGGCGTC	AATCGTGTCGTCTTCGCCCGGGCAGAGGTCGCTCGCGTCACACAC
GCCGTCGCTGTCGGCGTC	TTCAAACGCGTTTGAGCAGAC
GCCGTCGGTGCAGGAGTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036352.1\|WP_145127125.1\|2617832_2619389_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|143598
NZ_CP036352.1\|WP_145127102.1\|2608684_2610034_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
NZ_CP036352.1\|WP_145127128.1\|2619385_2620744_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273349
NZ_CP036352.1\|WP_145127120.1\|2615418_2617074_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP036352.1\|WP_145127088.1\|2603206_2605342_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP036352.1\|WP_145127081.1\|2598999_2599686_+\|zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|377289
NZ_CP036352.1\|WP_145127090.1\|2605350_2606010_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|132080
NZ_CP036352.1\|WP_145127099.1\|2607777_2608491_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_CP036352.1\|WP_145127114.1\|2612991_2613663_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145127134.1\|2621786_2622329_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|133478
NZ_CP036352.1\|WP_145127108.1\|2612104_2612287_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235240
NZ_CP036352.1\|WP_145127097.1\|2606953_2607781_-\|PilZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|377796
NZ_CP036352.1\|WP_145127131.1\|2620747_2621410_+\|TrkA-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|223643
NZ_CP036352.1\|WP_145127092.1\|2606010_2606484_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366645
NZ_CP036352.1\|WP_145127117.1\|2613659_2615195_-\|glycine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235240
NZ_CP036352.1\|WP_145127083.1\|2599689_2601036_-\|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|379311
NZ_CP036352.1\|WP_145127123.1\|2617137_2617638_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|238182
NZ_CP036352.1\|WP_145127110.1\|2612329_2612851_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|316802
NZ_CP036352.1\|WP_145127086.1\|2601077_2603210_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP036352.1\|WP_145127095.1\|2606584_2606899_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP036352.1\|WP_145127125.1\|2617832_2619389_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|143598	cd07574, nitrilase_Rim1_like, Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases). Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	1.48439e-140
NZ_CP036352.1\|WP_145127102.1\|2608684_2610034_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	2.21938e-169
NZ_CP036352.1\|WP_145127128.1\|2619385_2620744_+\|hypothetical-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	1.45462e-94
NZ_CP036352.1\|WP_145127120.1\|2615418_2617074_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.85302e-06
NZ_CP036352.1\|WP_145127088.1\|2603206_2605342_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.07139e-21
NZ_CP036352.1\|WP_145127081.1\|2598999_2599686_+\|zinc-metallopeptidase	gnl\|CDD\|377289	pfam04298, Zn_peptidase_2, Putative neutral zinc metallopeptidase. Zinc metallopeptidase zinc binding regions have been predicted in some family members by a pattern match (Prosite:PS00142), of the characteristic HEXXH motif.	3.74509e-98
NZ_CP036352.1\|WP_145127090.1\|2605350_2606010_+\|hypothetical-protein	gnl\|CDD\|132080	TIGR03035, trp_arylform, arylformamidase. One of several pathways of tryptophan degradation is as follows: tryptophan 2,3-dioxygenase (1.13.11.11) uses 02 to convert Trp to L-formylkynurenine. Arylformamidase (3.5.1.9) hydrolyzes the product to L-kynurenine and formate. Kynureninase (3.7.1.3) hydrolyzes L-kynurenine to anthranilate plus alanine. Members of the seed alignment for this model are bacterial predicted metal-dependent hydrolases. All are supported as arylformamidase (3.5.1.9) by an operon structure in which kynureninase and/or tryptophan 2,3-dioxygenase genes are adjacent. The members from Bacillus cereus, Pseudomonas aeruginosa and Ralstonia metallidurans were characterized. An example from Pseudomonas fluorescens is given the gene symbol qbsH instead of kynB because of its role in quinolobactin biosynthesis, which begins with tryptophan. All members of this family should be arylformamidase (3.5.1.9). [Energy metabolism, Amino acids and amines].	1.59853e-57
NZ_CP036352.1\|WP_145127110.1\|2612329_2612851_-\|hypothetical-protein	gnl\|CDD\|316802	pfam14312, FG-GAP_2, FG-GAP repeat.	5.08954e-10
NZ_CP036352.1\|WP_145127099.1\|2607777_2608491_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	0.000343624
NZ_CP036352.1\|WP_145127108.1\|2612104_2612287_-\|hypothetical-protein	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	1.55283e-21
NZ_CP036352.1\|WP_145127097.1\|2606953_2607781_-\|PilZ-domain-containing-protein	gnl\|CDD\|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	2.0636e-07
NZ_CP036352.1\|WP_145127131.1\|2620747_2621410_+\|TrkA-family-potassium-uptake-protein	gnl\|CDD\|223643	COG0569, TrkA, K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism].	3.87119e-32
NZ_CP036352.1\|WP_145127134.1\|2621786_2622329_-\|transcriptional-repressor	gnl\|CDD\|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	3.17731e-39
NZ_CP036352.1\|WP_145127092.1\|2606010_2606484_-\|hypothetical-protein	gnl\|CDD\|366645	pfam01442, Apolipoprotein, Apolipoprotein A1/A4/E domain. These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.	0.000745188
NZ_CP036352.1\|WP_145127117.1\|2613659_2615195_-\|glycine--tRNA-ligase	gnl\|CDD\|235240	PRK04173, PRK04173, glycyl-tRNA synthetase; Provisional.	0
NZ_CP036352.1\|WP_145127086.1\|2601077_2603210_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	8.47181e-21
NZ_CP036352.1\|WP_145127123.1\|2617137_2617638_-\|universal-stress-protein	gnl\|CDD\|238182	cd00293, USP_Like, Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.	9.20162e-29
NZ_CP036352.1\|WP_145127083.1\|2599689_2601036_-\|HEAT-repeat-domain-containing-protein	gnl\|CDD\|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	5.94163e-10

>NZ_CP036352.1|WP_145127102.1|2608684_2610034_-|GTPase-HflX
MKERKRIDLGVVAERAVLVGLILPGDAPRGTRYDPLAELASLAEAAGAQVVGRTIQKRGRIDSATYIGSGKVEELAAYADEKDADVIIFDNELTPSQIRELDKACKRRVIDRTELILDIFASRARTATARLQVELAQLEYTSPRLRGMWTHLERIAGAGGGTTAGAVGAIGTRGPGERQIEIDRRIVQKRVTFLRSQLAHIDQRRVREVKARGDYFTVSLVGYTNAGKSTLMNALTGAETYVADKLFATLDTRTRRWNFGGGQLALLSDTVGFVRDLPHQLVASFRATLEETIHSDLLLHVVDASAYDAIQQYEAVRSVLTELECDTIPSLVVLNKLDAVEDVGELAVLRAQLPEVAEISARTGAGLPELCDRVLAVMRDRFVRLILESSSANGRLISYISQHGHVLGREYVDGRVRMDVRLPRGEVARVVKMGASVVESAADASAATD
>NZ_CP036352.1|WP_145127099.1|2607777_2608491_-|PilZ-domain-containing-protein
MKQNVRLDAQAGQHALEQAVLYHAQAVINIPGRVDTTVNGFLLTADASTVLMEITGKPAIKPAELTGKLIHVELFSDQRYQFTTTVQSAPIWGASQALALARPNELTVIDRRRFWRAKLAPSARVALEWAHCGSRERHNAALLNVSVDGLACRVDKLAASAIEVQTSVKARFRMRESTREFELDSLVMNKTPASDGGFILGLQFARVFDSVAQLADLRKILNPGPPVPVSNEAEALT
>NZ_CP036352.1|WP_145127097.1|2606953_2607781_-|PilZ-domain-containing-protein
MNQASQTIPDGAPAAPSDGSPVEAVLIWAASKRVPVTVSLEQEGCWQNVRTQLVEFDAGEKLLKLEMTPAAGPGGDGIAVAPAAVQVAPGQLVGMTFRRGHKKCVFVTRVVVLQNAEGSDPASATQVLVLRAPRDVRELQRRSYQRITLPPDQFVAVRLWQGGLPSKDQTVGPSCSGRVGNISLGGILVDIRKEHNPRLTVGENVGVEITPRPGGAPLLVEGQYRHCVITGEDRLGLGVQFLGMERERPGCSTLADVNAFIGDVRRFATRGDWFA
>NZ_CP036352.1|WP_145127095.1|2606584_2606899_+|hypothetical-protein
MKSRMLWRPIQSQIFAVPLMEVVGTSTLHHNAADKSITGHAFGLRPGCDNCAPRRRVCLAPMQKLRHFDSNEDRVEINESGADIYREAVGLPLLGGTAWLGGSE
>NZ_CP036352.1|WP_145127092.1|2606010_2606484_-|hypothetical-protein
MKRSHQHRIWRTLAASVVFAACHGCDPATREQARKKADAARVTATQKAEETRVAATQAAHDVAQRVEPLIEAGRTTMQEAAQSVRDEAAELRDEARPYVEQAKVAATQAAERVRTATTQAAEKVKTATTQAIEKVKNATTQAVERVKGDSGKSGDSD
>NZ_CP036352.1|WP_145127090.1|2605350_2606010_+|hypothetical-protein
MLYDITPPISPDLAVWPGDTSPRREILLDLARGDNVTLSTLHATVHLGAHADGPNHYAQDGADIASRQLGYYLGPCRVVRTRTAKRTRVELADIATQLEAKDESGMGTRRPLPPRILIATGTAPDPIHFSQDFAGLDPDLVDALAARGVITIGVDTPSVDLFESKDLPAHQAFHRNDMAILEGLDLHAVPEGDYELIALPLPLMGFDASPVRAILRTLD
>NZ_CP036352.1|WP_145127088.1|2603206_2605342_+|tetratricopeptide-repeat-protein
MIEAAKSDANIRRPQSIAVPCIIAFVASAAVMIVELLAFRLVARWFGNSIFATTSIIGVVLGGLAIGNYVGGLLADRYRAGRCLSALFVLASAACFAVPILNKYAGAWSALSTLTLPQRIASHVVFVFMLPALLLGAIGPVVARMALLRSNRVGRTVGVVYALGALGSIVGTFACGFFLIPQFGNYVVIQAVAAGMALMAISCAATHWPPYAWTGATAALLFLGQSSASWAVDLGDTLGLREKLTEGVLFDADSEYSHVRVQVDADHPTRRRMILDKLCHSVMDSKNPHALQYGYERVYAAVADCVTKPGQPIRVLILGGGGYTHPRHILHMRPGSYVEVVEIDPVVTRAARETFGLAPQQGLEIVHLDARQHLTDLVRRRAAGEAIPLFDFVYLDAINDFSVPFHLMTQECHQLIAELMSDSAVYMINMVDIYAEGRLLGSSIRTLRRTFPFVEGFFASFEGDRLHHFDRYTFVLAASRRDMQLDRLKDSPTSRAIAKQQLTPAQFDTLLARCNPLVLVDDHAPMEFLLMNVVQSSRKAGWNEDARKAYSQGNAEFEQNRVPQAVEYYREAIRLDPTMYLAHLNLGLAYIELGQYDRANEAFRAAIDIQPNRADPFVNLGGLSMRTHDYDAACRHYEEAIAREPKDAHAHNGLGMALANLGRLTEARAAIQRAIELQPDYPAAVRNLAQVDAAIASRSSGRGTATAPAGD
>NZ_CP036352.1|WP_145127086.1|2601077_2603210_+|tetratricopeptide-repeat-protein
MNAPASQPAAADTRSGSIIGPCAIAFIASAAVMIVELLAFRLIARYLGSSNYTTTAIIGVVLGGLAIGNFIGGLLADRFRVGRMLALLFVLSSAGCFAVPVLNSLVGDWSALWFLSWPRRIATHVTLVFSLPAILLGTIGPVVARMALLRSERVGRTVGAVYACGALGSIIGTFACGFYLIPYFGNHAVIQAVGAGLAIMAIICARTYWATHAWTAATIVLVLIGAGPWAWAKGIGADLGLRERLTPNVLFDADSEYGHVRVEINPDHPTRRIMVLDKLEHSYIDTARPDVLQYGYERVYAAVTDHVAAGRDAIRALILGGGGYTHPRHILRERPRSEVEVVEIDPIVTQAAMEAFELSPQPGLTIVHLDARQHVADLVRWRAASGAIRPFDFVFLDAVNDFNVPFHLTTEEFQSSVAKLLGNDGVFLMTLIDIYEVGGFLGSTLRTMKESFSHVACFYAGYESEAFEPSSRYTFIVVASQRDLKLGEMEADSRHRATARQRLTSEQIEAVIKNPLATVLTDDHAPVEFLLMHVVELTGRSIWNEAAMRFYNRGNTDYALKRFDRAIESYLRAIELEPTMHMAHMNLGLAYKDTGRMDKAVEAFLAAAAARPDMPGPAMNLGGVYMLLHDYESARAAYEKAIQLDPQFAPAHNGLGMALANLGELVPARDALRRAVELDPAYAAAVNNFQRVEAAIRLRATSSAPSRIDP
>NZ_CP036352.1|WP_145127083.1|2599689_2601036_-|HEAT-repeat-domain-containing-protein
MRHHGSIRPSRPHPGNCFDPGVRRLSQVYNCVASRVGSRIVISTKGVLRAGVVCLCAAGAVRADVFHLREGGKLDGAIVEDLGDALRIRTVNGVSDIEKERVARIEKGDPPWVRYEKKLKKCGETIKDQLALADWCRATGMKTEERRHLDRVIALDAHHVDARRRLGFVQEGGKWIKPKSTGAMSEAERTERRRAQADERRVQEKITEYTVKVKAVYRGRLSEKVGGEGSKAFADGRRQILEISDPLAIPGITSVLSSGHVAARRLMVEALAQFDVDEATMNLVAIALLDPSKEVRAMAARALKPRKDDRIVLELRSALRSEEEAILRNAAAALGILKAKSAVRDLVPVLSTETVGLVRVSRWVSLDSLYGAYSDWQRYRVGGFPVLYKPSCIWAMGPGSIIGTVSGYEYQVISIHRTEVQEALIEISGQNLGFDAAAWLKWADDNGV
>NZ_CP036352.1|WP_145127081.1|2598999_2599686_+|zinc-metallopeptidase
MFFDPMYLVFMAPAILLALWAQVRVKSAFHHGNEFQPRSGLSGAETAQRILDTYQLHDVTIEPVNSFLGDHYDPRNKVLRLSPDVFNGRTLSALGIAAHEVGHAIQHAHSYGPLAVRNSLVPVAAVGTNLAWIFIIAGLALAPFRALAMVGLALFAAGVLFSIITLPVEFDASKRARAILLTNGMVTTEEDRIVGKVLNAAALTYVAAAIGALLQLAYWALVVFGRRD
>NZ_CP036352.1|WP_145127108.1|2612104_2612287_-|hypothetical-protein
MGKRHASINDAGTPYCFTVDGQTKEDGTVTVRDRDTGKQERIDKSRVVEFLTDKLTGAHG
>NZ_CP036352.1|WP_145127110.1|2612329_2612851_-|hypothetical-protein
MRTQRLLVSFASIVALSCFESTASGQCNPAEVAKHTALDGALNDNFGIIVAIDGDTAIVGAWGADTAGGSDAGAAGDALGYPVALSDDTAVVGAFSDDNGGGANAGAVYFLMLGCDDDGDGLINANDACPGNSPGVPVDATGRPLRDCNGDCNGDCAVNALDIQCIVDEMLNQ
>NZ_CP036352.1|WP_145127114.1|2612991_2613663_-|hypothetical-protein
MKLPLDNQTDAFVRAAGVGMIATLLISAAVSAGPGAASGSTSRPASQPSSSPAVELPDPPAGFSWKRIDTIGAAFLQPKGWHYRRMGSKDSEVYRISKDNTKKGEPFLTGLTVNVTRNVTKKSKISAKLYAVHYMKEYTKNVEVKLKPSLDKFASFDRLIFEVVKPIPESGSDGDFRVRIMMLANEKTDTLYTLFFGAPEEEWESAWKVGKRMLGLLYLDDDV
>NZ_CP036352.1|WP_145127117.1|2613659_2615195_-|glycine--tRNA-ligase
MPKDAAKMEKIVALCKRRGFIFQSSEIYGGINGFWDYGPLGVELKRNIKDAWWNDMVQHPPVGPDGREISMVGVDCSIIMNPKVWEASGHATGFADPMVDCKACKARFRADQLNAIELLFNNCDPVFRLYLSGTGTENEILESNKKKIDKLVAAKGKFEILLNQTEYAKLTDLGKSKFECPNCGEAGHLTEPRQFNLMFESHAGAVKDEDNKVWLRPETAQGIFANFKNVCDSTRVKIPFGIAQVGKAFRNEINPRNYTFRSREFEQMEIEFFCHDKDAMDWWKWWRDVRINWYKSLGLAGENLKPRNQDEKELAHYSKACTDIEYYFPFADEPQELEGVAHRGCFDLTQHQTHSGKDMSYFDDETKDRFTPTVIEPSAGADRSTLAFICEAYKHDPERASPEIMCFHPRLAPIKAAVFPLVNKDGMPEIAEPLFREIRKRWPAQYDAKQAIGKRYARMDEAGTPYCFTVDGQTKEDGTVTVRDRDSGKQERIDKSRVVDFLADKLTGANQ
>NZ_CP036352.1|WP_145127120.1|2615418_2617074_+|hypothetical-protein
MTRVSIAATLALFLLQSGCVQPAVQPPREEAAVLFDGMGDHERAVTTKSPNAQRYFNQGLTWSYAFNHDEAIRSFRTAARLDPDCAMAHWGVALCNGPHINNMIVLPEREKAAVEAVKRAQALRDKASLVERALIDAVAARYADPQPKDRTALNEAYAAAMKKVWQAHPNDVDVGSLYAEALMDLQPWDLWNKDGSPKGRVTEIIDVLDAVLAMSPNHPGALHLYIHALEGSPTPEKAVAAADRLRDRVPQSGHLQHMPSHIDVQVGAWTKAAEQNERAIVADTKYRAIMPTQGLYAGYMAHNAHFLMFASMMEGRRERAVGAAREMLAKIPPGFIRDMPQFADPYMGAAIDALKRFGRWDEILREPPPPAGLPISKAMWHFSRGVAYAAKHELGAATAEQSAFRAAAKRVPPEALMGANKGATIMEIAEHMLAGEIAFARGEIDSAVRELREAVKIEDTLLYTEPPDWIQPVRHTLGAVLASAGRHDEAEKVYREDLVHWPENGWSLFGLAKCLRARGATDEAATVDARFAKAWARADTKIGTSCLCVRE
>NZ_CP036352.1|WP_145127123.1|2617137_2617638_-|universal-stress-protein
MPVIQRILVPTDFSLLADHAAEYAELLAQSLGASVFAVYVLSPPAVVDGTGVAPGLAAAGIQPNLEANLENAKSSLADFVRRHFPSRDTVSEILIGTPYSQICQFAKDHSCDLIVVGSHARGVLQRIFLGSVSKCVLEHAPCPVLMVPIAAVEKPMESSHDATGAS
>NZ_CP036352.1|WP_145127125.1|2617832_2619389_+|GNAT-family-N-acetyltransferase
MSEPIEYTEERLRLRQVTLEDYESIRAMSERCFPGMKPWSREQIESQLTIFPEGQLCIELDGEIVASTCNLIVDFDDYDDWHNWKEISDSGFIRNHNPMGDTLYGIEIMVDPEYRGMRLARRLYDARKELCRERNLRCIVIAGRIPGYGQHADQVSAREYVERVIRKELIDPVLTAQLSNGFMLKGLIPDYLPSDSASRGYATFLEWSNLDFTEPSRRKYKAVSMVRICAVQYGMRAIRTFDEFATQCEFFIDTAADYKADFLLFPELFTTQLLSLVPKERPGIAARKLAEFTPQYMEMLSEKAIEYSVNIIGGSHFVVENGQLLNASFLFRRDGSVGKQYKLHITPSERRWWGVLPGNGVEVFDTDRGRIAIQICYDIEFPELARIAVAKGARIIFVPFNTSERYGYLRIRHCAQARAIENEIYVVTAGCTGNLPFVENADVHYAQSGIYTPSDFPFARDAIAAESGPNVETLVVHDVDLEILRRQRLNGTVTTWQDRRVDLYRVRYRDSDGRETEV
>NZ_CP036352.1|WP_145127128.1|2619385_2620744_+|hypothetical-protein
MINSALVRRPPLVKGPQRVVAAFALVILIGAALFHLPLCTNGKDVSFVDALFMSTSAVCVTGLTTVDVGEQLSPSGQFVLLVLFQLGGLGITTLSTFLLLAASRASLAHAVESGEQLGALRVKPLQLVRWVVLTTVTLEAAGALILWGRMNGDEGWWSGVFHSVSAFCNAGFSLHSDSLTSYRSDWVVNFTVMALIVHGGLGFIALRQLVEWIAARITGKPVRLLLHTRVVLLGSFALWGLGAAMLSWLEWNRTLAGLPSDERILAACFQSVSARTAGFNTVDIGALREPTLFFLMFLMFIGGAPGSCAGGIKVTTAAVVLAALVARARGRESVHLLQRTIPRELVRRSFVAMGMAAGMIALAIGVLLFSEEGPSTVPRADHLTVVAFEAVSAFGTVGLSTGLTPNLSAIGKLVLIVCMFVGRLGPLLVALAVLQPRERAGYSYPEEDLAIG
>NZ_CP036352.1|WP_145127131.1|2620747_2621410_+|TrkA-family-potassium-uptake-protein
MKSFVIVGLGRFGQCMLDSLIRRKCEVLVIDQDEDKIQWARDRATKAIKVDALNQELFTELLPDKVECAIVDLGDAMERSILVTNHLKKCGIEKIVVEAVNREHAEILEIVGATRIVYPEEEAAEHLAGLLAGGGALDFFAVSERFGMVEIPVPRDWAGKKPIELKLREKAGIEVVAVRSPTTDSSQENWQLLTGEYVFNPSDIVIVAGSSEGIGRLTKD
>NZ_CP036352.1|WP_145127134.1|2621786_2622329_-|transcriptional-repressor
MAQPADAETIATAENVFREFLRDRGLKYTDERQDILRAVMHNDEHFEAEQLLLDMRQKDSRVGKATVYRTLKLLVACGIVKEVHFSNKQVHYEHTYGQDPHDHMVCRRCGRIIEFGAADVVRLRAALAAQHRFHALAHRFQITGLCEACVKSCPIGLRAQTIVGPRGSAKPPRPNTKRRK

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Crispr_ID: NZ_CP036352_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036352_6

3793752-3793901

Orphan

Consensus_repeat	Method
GACGCCGTCGCCGTCGGCATC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP036352_6

>merge|NZ_CP036352|6|3793752-3793901|PILER-CR
GACGCCGTCGCCGTCGGAATCGTTGGCCGCGTCGAACGGGCACGCGTCGCACGCGTCGCCCAGACCGTCGCCGTCGGCATCCTCCTGACCAGGGTTGGCGTCGTCGGGGCAGTTGTCATCCTCGTCGGCGATGCCGTCGTCGTCGGCATC

>NZ_CP036352|6|3|3793752-3793901|PILER-CR
GACGCCGTCGCCGTCGGAATC	GTTGGCCGCGTCGAACGGGCACGCGTCGCACGCGTCGCCCAGA
CCGTCGCCGTCGGCATCCTCC	TGACCAGGGTTGGCGTCGTCGGGGCAGTTGTCATCCTCGTCGGCGATG
CCGTCGTCGTCGGCATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036352.1\|WP_145128832.1\|3794730_3795546_-\|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|131644
NZ_CP036352.1\|WP_145128818.1\|3787447_3787888_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
NZ_CP036352.1\|WP_145128845.1\|3803761_3805072_+\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|235963
NZ_CP036352.1\|WP_145128826.1\|3790487_3791009_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP036352.1\|WP_145128834.1\|3795828_3797073_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_CP036352.1\|WP_145128849.1\|3805765_3806452_-\|NTP-transferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|133025
NZ_CP036352.1\|WP_145128820.1\|3787886_3789158_+\|class-I-SAM-dependent-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|236981
NZ_CP036352.1\|WP_145128835.1\|3797131_3798766_-\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NZ_CP036352.1\|WP_145128841.1\|3800626_3802177_-\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223110
NZ_CP036352.1\|WP_145128847.1\|3805091_3805733_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370551
NZ_CP036352.1\|WP_145128814.1\|3785308_3786010_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293807
NZ_CP036352.1\|WP_145128816.1\|3785982_3787368_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|223283
NZ_CP036352.1\|WP_145128813.1\|3784561_3785284_+\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|223710
NZ_CP036352.1\|WP_145128839.1\|3800009_3800597_+\|nucleotidyltransferase-family-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145128811.1\|3783483_3784455_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
NZ_CP036352.1\|WP_145128837.1\|3798945_3799578_-\|dephospho-CoA-kinase	unknown	unknown	gnl\|CDD\|234620
NZ_CP036352.1\|WP_145128824.1\|3790040_3790397_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145128828.1\|3791102_3792557_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145128822.1\|3789190_3789781_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145128843.1\|3802299_3803646_+\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|107206

Protein	Function_ID	Function_description	E-value
NZ_CP036352.1\|WP_145128832.1\|3794730_3795546_-\|PEP-CTERM-sorting-domain-containing-protein	gnl\|CDD\|131644	TIGR02595, conserved_hypothetical_protein, PEP-CTERM protein-sorting domain. This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures].	0.00409242
NZ_CP036352.1\|WP_145128818.1\|3787447_3787888_-\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	1.02648e-15
NZ_CP036352.1\|WP_145128845.1\|3803761_3805072_+\|amidohydrolase-family-protein	gnl\|CDD\|235963	PRK07203, PRK07203, putative aminohydrolase SsnA.	1.47064e-138
NZ_CP036352.1\|WP_145128826.1\|3790487_3791009_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39788e-14
NZ_CP036352.1\|WP_145128834.1\|3795828_3797073_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	4.2505e-22
NZ_CP036352.1\|WP_145128813.1\|3784561_3785284_+\|HAD-hydrolase-like-protein	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	9.92746e-39
NZ_CP036352.1\|WP_145128835.1\|3797131_3798766_-\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NZ_CP036352.1\|WP_145128841.1\|3800626_3802177_-\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223110	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism].	4.29105e-34
NZ_CP036352.1\|WP_145128814.1\|3785308_3786010_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	9.2635e-55
NZ_CP036352.1\|WP_145128816.1\|3785982_3787368_-\|6-phosphofructokinase	gnl\|CDD\|223283	COG0205, PfkA, 6-phosphofructokinase [Carbohydrate transport and metabolism].	4.59111e-73
NZ_CP036352.1\|WP_145128811.1\|3783483_3784455_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	3.80368e-165
NZ_CP036352.1\|WP_145128847.1\|3805091_3805733_+\|hypothetical-protein	gnl\|CDD\|370551	pfam09538, FYDLN_acid, Protein of unknown function (FYDLN_acid). Members of this family are bacterial proteins with a conserved motif [KR]FYDLN, sometimes flanked by a pair of CXXC motifs, followed by a long region of low complexity sequence in which roughly half the residues are Asp and Glu, including multiple runs of five or more acidic residues. The function of members of this family is unknown.	1.0483e-05
NZ_CP036352.1\|WP_145128820.1\|3787886_3789158_+\|class-I-SAM-dependent-RNA-methyltransferase	gnl\|CDD\|236981	PRK11783, rlmL, bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL.	3.92475e-108
NZ_CP036352.1\|WP_145128849.1\|3805765_3806452_-\|NTP-transferase-domain-containing-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	9.52625e-33
NZ_CP036352.1\|WP_145128837.1\|3798945_3799578_-\|dephospho-CoA-kinase	gnl\|CDD\|234620	PRK00081, coaE, dephospho-CoA kinase; Reviewed.	1.1586e-54
NZ_CP036352.1\|WP_145128843.1\|3802299_3803646_+\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|107206	cd01563, Thr-synth_1, Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.	1.82037e-97

>NZ_CP036352.1|WP_145128828.1|3791102_3792557_+|hypothetical-protein
MFQPVLIWLILPFCIAQDDSASGWSRDMPEALRKALDYRSKPRTGYAKFKVKSRVGYAPIVEARYEQRFAGNNVVSRYAYGEGRDDRELFLAEDGLTVNCINNPPSVYGSKASSPLTPDIRTLGLIPGLFSSMNLTDCINMLTVQGKREYRWRMAGDGKIHVEGRNNKESGATDEINWIIDPSRDFSIVHIARTLNSPPYGEKTYYESKIEIGQFDGFWWPRRVTAQRDSTKLAVDVDVLELEFNRAAHPQKIGVDQLELPIGMLVNITMSKCEDWGWHELQTFEYTGDNNLVPKGEPHRIKVSNYNIPRLIDSGQFTRTADGNLHIEVTPTMVNSDGKMGPYPPESRSTIAGNPDEWEIYVRRWIARYSGEGPTPVKVPLDEKQKAAAMAILEDCRKQARPLVERRKAERIEAEKTFNARNAAVLAASRGDAKPPSALVQDFQAAQKRVSALQQPDPQVEAIFESLKMRLNGLPTAKQRMPGR
>NZ_CP036352.1|WP_145128826.1|3790487_3791009_+|GNAT-family-N-acetyltransferase
MNQFDSHPTIRPAADSRDFSEIGLLMREYLTELGVDLCFQDFEGEVADLPRTYAAPDGALLIARAEIDPSSRHQPTDRAAAAGCVALRRVGDTLCEMKRLYVRPAHRGSGLGRRLVEAALDRAREMGFSRVCLNTVVPKMPTAVALYRSMGFVEIEPFDCHPVDGTLAMGRPL
>NZ_CP036352.1|WP_145128824.1|3790040_3790397_+|hypothetical-protein
MAKRRGSNGRQATKDKGVIVSFRVDRHLADVLNQVPDKSAFIRDIILRSFYETCPVCRGRGVLPAELSRWAAGRLKADASVECSCCLYGYPKQTLPAKHRKTAEPFVCPHCESHDHRH
>NZ_CP036352.1|WP_145128822.1|3789190_3789781_-|hypothetical-protein
MTLKPPSSTDESDKASPNSRHEPDASLSARPRIRFNPLNLTLAGLPEMDYFESDEKRIAALRQIAKDAGRPNQWSYWVGVGLIWLVSMSVYFFGRYAMHFVQWPSLMEKALSFVVMLLAAVLLIRRFHRQGMQSMLRSELLKQGVPVCIKCGYLLRGLTVETGRCPECGREFDGLVRAIITNAQVNAAESDGAPHK
>NZ_CP036352.1|WP_145128820.1|3787886_3789158_+|class-I-SAM-dependent-RNA-methyltransferase
MALSLDEKREIRVTCALLIPPYLRAEIETLGYQLIDEGRAYVELFGTLRDAMRLNLHLRTAQHVLCLLNRFDCDGPDQLYRAVNALPWETIVAADGYLTVSSSVNHPTINSWAFASLKVKDAIVDRIADKLGRRPDSGPDRRGVVVHLEWHGDQAAVYLNTSGNKLSDRGYRRIPHKAPMAETLAAAVLMAAGYDGSGVLVNPMCGSGTLAIEAALMATGRAPGLLRSDYGLLHVLGMDTEAWQAARREAAKGNAATRGNAAVKSRNKTGGSMIIASDIDPAALAAAKQNAKTAGVDHLIEFAQCDFAETRVPELGEGSGIVLLNPEYGERMGDEKALEATYARIGDFFKQRCAGYTGLIFTGNRNLAKHVGLRASRRIEFWNARIDCRLMRYEMYRGTREAYGASGQLKLGDSKSRPSEPRP
>NZ_CP036352.1|WP_145128818.1|3787447_3787888_-|VOC-family-protein
MMPVHYHSGGPSMNPKLYRVIVPVADIEQAAAFYAAVLGMPGMRVSDGRHYFDCDGTILACYDPKADGDDGRPTPLPEHLYLAVDDLEHVYIACQKAGAVFDTGDVHGDPAGKVATRPWGERSFYFADPFGNKLCFVDRRTVFTGR
>NZ_CP036352.1|WP_145128816.1|3785982_3787368_-|6-phosphofructokinase
MAHSRLAIIVGGGPAPGINAVIGATTIEAINKGMTVVGILDGFKHLSSDRFVAERHTEELTISRVARIHFDGGSILRTARTTLLDESALDEDMTVRPDNAKVDRVLRHFTELGVTHVVTIGGDDTALSARFVSERSHGRIRVVHVPKTIDNDLPLPGDIPTFGFNTARHLGSELIANLMEDAKTTGRWYIVVAMGRHAGFLALGMGKATGATLTLIPEEFAETVTLGQIADVLEGAIIKRRAMGRVDGVAIVAEGLAYRLGDREELERMLNKKVPMDAAGHLRLAEVPLARMLTDELTRRFGERSDSLTIIPQTIGYMLRCAPPTPLDIAYCRELGNGAIRILLDPKIDLSVGVMVTIQSNELVPMRFSDMVDPQTNRTRIRQVDIDSDGYRTARAYMIRLESEDLDNPVMLAKLTTAAKMDEAEFRKRFRRAATRLQRCPATGRMEIPADEVQAPSHAAR
>NZ_CP036352.1|WP_145128814.1|3785308_3786010_+|MBL-fold-metallo-hydrolase
MIRNVARNIWQISGFPAGAINSYLIGDGDRHILIDAGSKLDRRIILRHLRGASVSLLALTHVHPDHQGAAAAACDAFKCPLACHDADRPAMEGRSPMLPDNRPIRWSSRFFAGPARQVDQALREGDDVVGLRVIEAPGHTPGHVIFFREADRVAIAGDLATNMNFLTMRPGLHQPPAFFSVDPAQNRTSFKKLVELNPAMVLFGHGPPLRDMDALRAFAQRLERGQRAACEGA
>NZ_CP036352.1|WP_145128813.1|3784561_3785284_+|HAD-hydrolase-like-protein
MQPMLRAIIFDFDGVIADTEPLHFAAFERVLRDTPLAITQEEYFARYVGLSDRVFLERLAADRRAAVTNELPRYFDEKYHVYLELIGRGTSLIAGLREFLADLPPTLPVAICSGARRPEIDLILSQHDLAARFPIIITSEDVHSSKPEPHGYLMTLHKLRARHLYGSEKSRDIDPVDAMPADSCLAIEDSPQGILAARAAGMRTLAMLPSHIASDVSAADLRRENFRGLTWDDLCYRFVS
>NZ_CP036352.1|WP_145128811.1|3783483_3784455_+|tryptophan--tRNA-ligase
MRILSGVQPSGKLHLGNYFGAMKQHIEMQHAHECYIFIANYHALTTIQDPARLTGLTRDVAIDYLALGLDPAKACLFRQSDVPEVCELAWILSTVTGKGLLERAVSYKDKTARGLSASMGLFSYPLLQAADILIYRSDAVPVGKDQVQHIEMTADMAGYFHNTYKCEVFTLPQAKLNDAAIVPGLDGEKMSKSYGNTIDLFEDARSAKKKIMAIKTDSTPVESPKNPDTCTVFALLKLFLDATELADWRRRYEQGGMGYGDAKKRLAEAFEAKFGPAREKRAALEKDTAYIEDVLAAAGKKARTVAQAVMEDVRRACGIVVSR
>NZ_CP036352.1|WP_145128832.1|3794730_3795546_-|PEP-CTERM-sorting-domain-containing-protein
MRRVLLLVAAVSLVATPSFGQLIVGNDQSGTATIFNVNPTTGVATPIYSGAGTDAKPWGMAYDAATNTLYWNNGSTLFKSPFGPVLTPTNVGTMMFNAATINFVGLGFKNGKLYGTRNIATEAVYEIDPGTLVASQVYVHPSTYDYGGLDFDLTDGKLYGLSDTAPAPNVRGLYHIDTAGASETFLAPYPAGETDIDGLAVHAGIAYYVTDGPNTTQPNFYIYDVATGNLLGTLPSPFTGSGTFSAAAWAPEPASLALMALVGMSLVRRRR
>NZ_CP036352.1|WP_145128834.1|3795828_3797073_-|alpha/beta-hydrolase-fold-domain-containing-protein
MEPPSIVRGQLPASCRGEVAMVAGAPIIQRTLLFTLAALLGAVTRPVPAKAQITPTFNDVPYAVVPLDAGGTMTVFLDVYMPTAGTPPHPMLLWIHGGGWQGGTHNNVPAMALQLRDQGFVVASVNYRLSGSAVFPAQIHDVKGAVRFLRANAATYSLDVNRFGSWGTSAGGHLSALLATSGDAPALEGTSGGNLAFSSAVQAAVDFFGPTDILNMQLDVTTPPGGAFNHDDPGSPESHLVGWDAPGQGIGNIRANLANPTPPYPALVQLCMQVNPITWLTPGDPPLFISHGTSDTAVPIRQSVRLCDAMYAANLYRDYRPVTGAGHGPLGATTEAAARVFLIHRLTPIPFVPGDLNCDGTLSAADLEPMVLALMNPAGHTAAFPSCDIGRADCNSDQRLDGGDIRAFVEMLVP
>NZ_CP036352.1|WP_145128835.1|3797131_3798766_-|transcription-termination-factor-Rho
MPRPGHNRAHPPRKPRRPGDGPSAKHPRQPMRREPVRNEKPSGVVVESFEPQDDELDLEPVAQNDAPVRTESPARAETEGAGFSAGLAGEGGAPREGAMGPTGEGATPGGPGLDRETHERYEKVKRGDLHITELQKMSVNDLHDLAKQEGITDYALMKKQELIFKILKERINKNGLMYGEGVLEILPDGFGFLRSPEYNYVPCPDDIYISPSQIRRFGLRSGHIVAGQIRPPKESEKYFALLRVEAICFEEPDKVTEKAVFEDLTPHHPIKRIVLETSNDEINMRVIDIVTPIGFGQRMLIVAPPRTGKTVLMQKMANAITTNHPDAYVIILLVDERPEEVTEMQRHTKAEVVSSTFDEPASRHVQVAEMVIEKARRLVEYGRDVVILLDSITRLARAYNTEVPHSGKILTGGVDANALQKPKRFFGAARAVEEGGSLTIIGTALVDTGSKMDEVIFEEFKGTGNSELHLDRRLVDKRIWPAIDIAGSGTRKEELLLDPKELELVYKLRRVLVDMNPVEAMELLTTRLKKVKSNAEFLMTMNLA
>NZ_CP036352.1|WP_145128837.1|3798945_3799578_-|dephospho-CoA-kinase
MTKEGRSKPVVGLSGGIGSGKSTVASILADLGAAVISSDALNTLELASPEVQQTLIGWWGDSIRSPEGGVDRRKVSELIFDDESQRLRLQALLHPRIAARRSVLMADAEVNPTVRMVVVDSPLLFETGLDQMCDTVVFVDTTEELRKGRSEKARHWTPGELKRRENSQYPLDMKRARADHMVHNNSTLTDLRQQVERVFAAVLADFGERS
>NZ_CP036352.1|WP_145128839.1|3800009_3800597_+|nucleotidyltransferase-family-protein
MSNVLSYRAFVMAMERVERRLRQVTAALDAAGIRYAVIGGNAVAVWVAKSDPAATRTTKDVDLLVEQCDLPRIRVAIEGIGFQYTDLRRVVLFTDPDEPSRMSGVHLIWAGKKVRPSYSHPAPTLDEAVRDAEGFAVLNLPALVRMKLTSMRDMDRVHVADLLRVGMIDESVRRALPTDLLARLDEIARSIEDEM
>NZ_CP036352.1|WP_145128841.1|3800626_3802177_-|pyridoxal-phosphate-dependent-enzyme
MSTKISPESALTNAIALCRERNIVIPTFAQQKDPSLIPPRIKDRLKNVGLWDVDPANLFRITWKNEPVACGGGYNNGNWIEFPPALTGVPARIIGIVGKHFPTGAHKVGAAFGCLVPRLVTGQFDPTTQKAVWPSTGNYCRGGAYDCVLLGCTAVAILPEGMSRERFEWLRSIGAEVIATPGCESNVKEIYDKCWEIRRTRPDCVIFNQFEEFGNAAWHYHVTGSIVEDIFRQLHASLPINEPRASARADSNTAHAPDAPRGRKSAAPFRLAGYVSATGSAGTIAAGDYLRTIAPHVRVVAVEALQCPTLLACGFGDHRIEGIGDKHIPWIHNVRNTDLVAAIDDEQCLALMRLFNEDAGRKVLEAEGVARDVIDRLPDIGISSMCNLVAAIKTAKHYEMDGRDVLFIPLTDSMELYASRIEEQRAAHGAYSDSLAGRHFARYLEGIGVDHLRELGYHDRKALHNFKYFTWVEQQQRGVDELRRLWDPDFWTQQFEEAAGWDARIEEFNREVGLGS
>NZ_CP036352.1|WP_145128843.1|3802299_3803646_+|pyridoxal-phosphate-dependent-enzyme
MSLATQLICVSCEKEFPPAAGWTCPACGPDEGILDVQYDLPRVRQTLTRAALATRPLSHWRYAELLPVAVPPPAGIEQIGWTPLVDAPRLAAALGIGRLRLKDDGRSASASFKDRASSIGVAHAIQTLVATASHHGGSSTSSGTSRDRADPRATPIAIQIACASTGNAASSLAHCAAAAGLACNIFVPRTVPEGKLTQLLAYGARVFKVMGSYAEAYDLCTTACARFGWYNRNCAVNPYLVEGKKTGGLEVAEQCADDPPEWVAVSIGDGCTIAGIYKGLRQMREAGVISWNARMLGVQAAGVAPITNLWQRLIAGESLEKLTNRELHSRDTTYADSINCPVPRNWRKALAALRDSGGACVAVTDEQIMEAVRTTGRLSGVFAEPAAAAAVAGIAQARRDGILTERSSVVAMITGNGLKDTAGALRAVGKPHEIKPDVGEVERIIRQE
>NZ_CP036352.1|WP_145128845.1|3803761_3805072_+|amidohydrolase-family-protein
MSTILTNAILCDLDPPRVQLGALRIEDGLITHRGRSVPAGRDDEVIDLGGAVVMPGLVNGHTHLYSALAVGMPPSPKTPRNFLQILKYVWWRLDQALDAESIEMSARIGALEALRCGTTTLIDHHASPCAIDGSLDRIEAGLHAVGLRGVLCYETTDRHGRAGREAGLAENARYIVKCRDHGRGRFAGLVGAHACFTLEDESLRALADLSQKTRCGVHIHVAEDPCDERACRRQHRKSLIARLTAFGLLHERSIFAHGTHLDAAAIKRVRAAKVTMAHNARSNMNNAVGYAPVAEFGPRVMLGTDGIGANMFGEARAAWFIARHSGSRLAPGDIVAMLAQSARRASASLGVTLGKLQPRAVADVVITNHRPFTPIDTSNLTGHLLFGLGPQHVESVMIGGRWKLRGGKVLECDEVGAREAAVGISKRMWKKMENFK
>NZ_CP036352.1|WP_145128847.1|3805091_3805733_+|hypothetical-protein
MLFKLEKIIPGELAYPMPLVTRIVVWTALCAGCAGPSILLAVLVRANHLALAISCIAFVAAYVVLTGTEFWISLWQRDSARRAIIAGFTLRILASIVFPLGMMLDMIPGMLIAELVGFDTENFHELSAAQTFVMAFLFGISMNFILWLGIAMLYPITYRIKPSKRPAGVCKRCGYDLRASPIRCPECGEPTPAAALPSVEAPPGAPRHSESQT
>NZ_CP036352.1|WP_145128849.1|3805765_3806452_-|NTP-transferase-domain-containing-protein
MNDRDRIFAMIPAAGLSRRMGRPKQLIAVNGQPMVLRLAESMAAVDAIAGVMVVTRRAIADALGATKIESSHGRIRIAFNEDESSEMIDSVRIGLRALGETWGRGRAGIGEFSPHDGILVCPGDYPGLTTDAFAACAGAYLAAISRESKTSGASDCAHGRPPIIIASHGGRRGHPIIFPVELIPFVMSPACDGGLNALTREFADRVRLVDLPTDAVLRDADTPDDLTD

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Crispr_ID: NZ_CP036352_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP036352_7

4189877-4189977

Orphan

Consensus_repeat	Method
GCCAATCCGGTGCGTTGAGTCGAGGATCCGCCGTGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP036352_7

>merge|NZ_CP036352|7|4189877-4189977|CRISPRCasFinder
GCCAATCCGGTGCGTTGAGTCGAGGATCCGCCGTGGCGAAGACGCACGCTACATTTACTCTTGGCCAATCCGGTGCGTCGAGTCGAGGATCCGCCGTGGCG

>NZ_CP036352|7|3|4189877-4189977|CRISPRCasFinder
GCCAATCCGGTGCGTTGAGTCGAGGATCCGCCGTGGCG	AAGACGCACGCTACATTTACTCTTG
GCCAATCCGGTGCGTCGAGTCGAGGATCCGCCGTGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP036352.1\|WP_145129427.1\|4185341_4186100_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145129425.1\|4184747_4185242_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP036352.1\|WP_145129418.1\|4179001_4181095_-\|ATP-dependent-DNA-helicase-RecG	unknown	unknown	gnl\|CDD\|236794
NZ_CP036352.1\|WP_145129444.1\|4197802_4199371_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|227111
NZ_CP036352.1\|WP_145129434.1\|4190941_4192441_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|273453
NZ_CP036352.1\|WP_145129432.1\|4190150_4190771_-\|DUF2238-domain-containing-protein	unknown	unknown	gnl\|CDD\|378345
NZ_CP036352.1\|WP_145129451.1\|4202935_4204348_-\|trehalose-6-phosphate-synthase	unknown	unknown	gnl\|CDD\|184712
NZ_CP036352.1\|WP_145129447.1\|4199478_4200255_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|235664
NZ_CP036352.1\|WP_145129424.1\|4182723_4184706_+\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236319
NZ_CP036352.1\|WP_145129430.1\|4189277_4189766_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|163518
NZ_CP036352.1\|WP_145129417.1\|4177740_4178961_+\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|239264
NZ_CP036352.1\|WP_145129415.1\|4175784_4177566_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224720
NZ_CP036352.1\|WP_145129422.1\|4181501_4182824_-\|DUF21-domain-containing-protein	unknown	unknown	gnl\|CDD\|224173
NZ_CP036352.1\|WP_145129449.1\|4200349_4202926_-\|trehalose-phosphatase	unknown	unknown	gnl\|CDD\|225922
NZ_CP036352.1\|WP_145129436.1\|4192624_4193923_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP036352.1\|WP_145129442.1\|4197248_4197818_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP036352.1\|WP_145129438.1\|4194110_4195910_-\|HYR-domain-containing-protein	unknown	unknown	gnl\|CDD\|367105
NZ_CP036352.1\|WP_145129428.1\|4186188_4188831_-\|ATP-dependent-chaperone-ClpB	unknown	unknown	gnl\|CDD\|274529
NZ_CP036352.1\|WP_145129420.1\|4181091_4181526_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|236880
NZ_CP036352.1\|WP_145129440.1\|4196091_4197030_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676

Protein	Function_ID	Function_description	E-value
NZ_CP036352.1\|WP_145129418.1\|4179001_4181095_-\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_CP036352.1\|WP_145129444.1\|4197802_4199371_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP036352.1\|WP_145129432.1\|4190150_4190771_-\|DUF2238-domain-containing-protein	gnl\|CDD\|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	6.1522e-76
NZ_CP036352.1\|WP_145129451.1\|4202935_4204348_-\|trehalose-6-phosphate-synthase	gnl\|CDD\|184712	PRK14501, PRK14501, putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional.	0
NZ_CP036352.1\|WP_145129447.1\|4199478_4200255_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|235664	PRK05995, PRK05995, enoyl-CoA hydratase; Provisional.	1.46813e-117
NZ_CP036352.1\|WP_145129428.1\|4186188_4188831_-\|ATP-dependent-chaperone-ClpB	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
NZ_CP036352.1\|WP_145129430.1\|4189277_4189766_+\|hypothetical-protein	gnl\|CDD\|163518	TIGR03806, chp_HNE_0200, conserved hypothetical protein, HNE_0200 family. The model TIGR03805 describes an uncharacterized protein family that contains repeats associated with the formation of a right-handed helical stack of parallel beta strands, homologous to those found in a number of carbohydrate-binding proteins and sugar hydrolases. This model describes another uncharacterized protein family, found in the same species as TIGR03805 member proteins, usually as the adjacent gene or in a fusion protein. An example is HNE_0200 from Hyphomonas neptunium ATCC 15444. Sometimes two members of this family are with a single member of TIGR03805. The function is unknown. [Hypothetical proteins, Conserved].	5.22061e-09
NZ_CP036352.1\|WP_145129417.1\|4177740_4178961_+\|redoxin-domain-containing-protein	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	8.6166e-36
NZ_CP036352.1\|WP_145129415.1\|4175784_4177566_+\|hypothetical-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	5.94522e-08
NZ_CP036352.1\|WP_145129420.1\|4181091_4181526_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	8.89232e-12
NZ_CP036352.1\|WP_145129449.1\|4200349_4202926_-\|trehalose-phosphatase	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	1.15976e-91
NZ_CP036352.1\|WP_145129424.1\|4182723_4184706_+\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236319	PRK08641, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
NZ_CP036352.1\|WP_145129436.1\|4192624_4193923_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.01905e-70
NZ_CP036352.1\|WP_145129442.1\|4197248_4197818_-\|hypothetical-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	6.08245e-27
NZ_CP036352.1\|WP_145129438.1\|4194110_4195910_-\|HYR-domain-containing-protein	gnl\|CDD\|367105	pfam02494, HYR, HYR domain. This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.	2.06788e-05
NZ_CP036352.1\|WP_145129434.1\|4190941_4192441_-\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|273453	TIGR01125, Ribosomal_protein_S12_methylthiotransferase_RimO, ribosomal protein S12 methylthiotransferase RimO. Members of this protein are the methylthiotransferase RimO, which modifies a conserved Asp residue in ribosomal protein S12. This clade of radical SAM family proteins is closely related to the tRNA modification bifunctional enzyme MiaB (see TIGR01574), and it catalyzes the same two types of reactions: a radical-mechanism sulfur insertion, and a methylation of the inserted sulfur. This clade spans alpha and gamma proteobacteria, cyano bacteria, Deinococcus, Porphyromonas, Aquifex, Helicobacter, Campylobacter, Thermotoga, Chlamydia, Streptococcus coelicolor and Clostridium, but does not include most other gram positive bacteria, archaea or eukaryotes. [Protein synthesis, Ribosomal proteins: synthesis and modification].	3.55904e-143
NZ_CP036352.1\|WP_145129422.1\|4181501_4182824_-\|DUF21-domain-containing-protein	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	9.51645e-77
NZ_CP036352.1\|WP_145129440.1\|4196091_4197030_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	1.26116e-154

>NZ_CP036352.1|WP_145129430.1|4189277_4189766_+|hypothetical-protein
MAAHEFLKRTYLLSALLVVALGCLLGAGMECPMQAGDELPPDMDMEEEEEPKSVSFGKDIQPIFDTHCIRCHVNGGFANNSGIPLRLVEGVSHELLVGKFSVQNTDLFLVKPGDHLNSLLYLKISQDTPPVGRRMPWDAATVVTEEEIALIVTWINEGAVNN
>NZ_CP036352.1|WP_145129428.1|4186188_4188831_-|ATP-dependent-chaperone-ClpB
MRLDQLTIKAMEALQGAESLARRQGHPELSPLHLLAALVEGAREGAGSDAGIVVPLLQKAGANVNQVRSIVQSELSRLPKVSGSSPSPARALQDVLESAQTIAEKMKDEYVSTEHLLLALAEVKSDAREILTVSGAGRPAIEKALAELRGGTRVTSQNPEDTFQALEKYGHDLVELARKGKLDPVIGRDEEIRRCIQVLARRTKNNPVLIGEPGVGKTAIIEGLAQRILAGDVPEALKNKRVVSLDMGALIAGAKYRGEFEERLKAVVREVVESAGAIILFVDELHTVVGAGKTEGSMDAGNLLKPALARGELRCIGATTLEEYRRHIEKDKALERRFQTVYVGEPSVEDTIAILRGLKPKYETHHAVRIQDSAIVAAATLSHRYIADRHLPDKAIDLMDEAASRLRIENDSLPAELDELRRRIMQLEIEREALKKEKDDASRKQLATGEKQLADLKERNTALTAAWENEKKQIESIKAVRQRIESLQTELDEAQRRGELERAARVRYGDLPEAQKHLHEAEERLAALHREGGGLLREEVTAEEIAEIVSKWTGIPVARMLEGEKEKLLKMEDRLHARVVGQEDAVRAVADAVRRSRAGLGDPNRPIGSFLFLGPTGVGKTELCKALAAFLFDDESAFIRIDMSEFMEQHSVARLIGAPPGYVGYEEGGRLTEAVHRKPYSVILLDEIEKAHRDVFNVLLQVLDDGRLTDGHGRTVDFRNAIVVMTSNIGSEHIQQLSESGAADAEIEHAVREDLKRHFRPEFLNRVDETIIFHRLGREHLRSIVDIQLKHLRERLTERGIALTLTPKAVDKLANDGYDPVYGARPLKRLIQQEVENPLARHILSGDFAPGQSVTVDVGGDGFIFSQSDREYTAVAATAR
>NZ_CP036352.1|WP_145129427.1|4185341_4186100_-|hypothetical-protein
MSRHIPSGHGALDVSYSPELSQCCLTFSDAIKSERLQHQQVVTLSTGMTDLLGRSNVHSSVAGLECCSLVRRRNYLLIAWQRKAIVLVLFVQLTAVACNAPKSLLTGTWEFEEVTEGWLTPSGIDVVVPPTTQPSDQTKLKLTFRDDGTLDFSQFVMFGDTIFNKLQRVGDVFYMLELDFPVHHEVQWSEYKTKESGLMVKMTRMDDPAKPAMIWFVSVSHNEDGTLRYFDCMAAQADRNFVRMGTLRRCSP
>NZ_CP036352.1|WP_145129425.1|4184747_4185242_-|hypothetical-protein
MEPEFIGVTREAATQWLSTHGYHAPLESAFPFHQRIPVPSDAGRRTSFVKHVLSWLPSDGIGLLHVTTWGVWPSNENMDLFSRVRATLGENRPIHEAPGQIMPLSERAALECILDIFVYFLWDAIFADDQHRFLFRSSHDEFIELACSEDLAGCARETIEAFLT
>NZ_CP036352.1|WP_145129424.1|4182723_4184706_+|succinate-dehydrogenase-flavoprotein-subunit
MAKQRVAMIGGGLAGLAGAMKLAEEGVAVDLVSMVPVKRSHSVCAQGGINSVNTVTRSQGDSEWKHLDDTVYGGDFLNHQPPVKEMTDWGPKVIDLLDRLGVPFNRTPEGNLDRRRFGGTLYKRTAFSGATTGQQLLYALDEQVRRWEAEGLITKYEHWEFLGLILDDAGVCKGCVIQDMFSMQLKALRADAVVLATGGCGLIFGKSTMSMICTGGANARAYQEGVKYANGEFIQVHPTAIPGADKLRLMSESARGEGGRVWVPRKPQDPRDPLTIPESERYYFLEERYPTYGNLVPRDIATREIFDVCVNGGLSVEKEDLCVYLDLTHLPSTAHHKLEGILEIYEKFAGGDPRTTPMKIFPAVHYSMGGLWVDYEKDAKTGGLALGSPRNQMTNVKGVFAIGEADYQYHGANRLGANSLLSCIFAGLINAPSIINYFKSCKSAAADAPAGLFDGAIKRHQDKFKALAARTGEENAYELHLELGRTMTANCTVVRYNDKIKQTLAKIDEIAARYQKAPLSDTGQWTNQNLSFVRALGDMIVLAKVIALGALQRDECRGAHYKPDFEISGLDPAAGDMTAQAKKWCQLFKKRNDDWLKTTIAEHTPAGPKLTYEPVDVSLIPPRPRTYGLKGAEEIERIWKTEFSGGGSGTTKKEPAAVGA
>NZ_CP036352.1|WP_145129422.1|4181501_4182824_-|DUF21-domain-containing-protein
MLTRSTATPSSASFIAPANPARPPPIIATRCFAIAVCHPRAAATRCRGEPILRCMATERQAGLRERPFCGTDAVRLSYGRPMPEPSLFLQLLLVPILIGVNAFFVAAEYAVVTMRGTRIEELRRQGLEAALLLSRLKEDVSGSLATIQICITATNLLIGAVAEPSMTRLIVGMLRPLDFVLPASYARPIGLVTGLLVVTFMTVVLSELLPKALTLQYTERIALFVARPIQLCHIVCLPLVRVMNWTGNCIVRLLGLGKIKIEEPVPTEDELEIMVDRADDAGEFQEEHGELLRRAFDFADLTVRHVMIPMHSAGVAPSNWTVEELAAYLHERPYTRWPIRDPATGRVNGVVNVKMALYANAIAAGQAVILHDLATPVRYLDPDEPLIDALEDLRTSRQHLAVVRDKTGSELGIVTLEDILASIVGDIRSETRQWPIRRPR
>NZ_CP036352.1|WP_145129420.1|4181091_4181526_-|LysM-peptidoglycan-binding-domain-containing-protein
MADPPPALTAPAYDDDNFTAMATWIPFRVPRTRVSAVMGGFLCAGMLLAASGCPASDRATSQPAAEGDSNGETVAQAGADEAVDLVRPGEIPGRVHIVERGDTLYSLASRYYGNGQQYNRILVANRNRLKDPRNLPVGMKLIIP
>NZ_CP036352.1|WP_145129418.1|4179001_4181095_-|ATP-dependent-DNA-helicase-RecG
MSTAAARPAPSLTDQVQFLPGVGPKRAAALERMGIRTCGDLLYHLPHRHERNEARTIIHLDFDTTATIVGRITAVRTEGRWRGGRTTATLIDNTGRCSLVWFSAPWMADKIHRGDIVRVSGRVTEYQRLPQLVNPKIAVLGADAPPVDESAPARFEAVYPASQELPAPVIAKLIHTHLDRLLSLVHDPLPPEHLKRRGLVGLAAALRGMHRPRSDGESIQARKRLAYDELLLLQLAVGRRRATRAGDSARPLPSSPEIDARIRRRFPFSLTPGQDRAIRAVTADLARRRPMHRLLQGDVGCGKTIVAVYAALVAVANRSQAAIMAPTELLAEQHMRSITRYLEGSRVRFARLTGGLRKADRAAILRALADGEIDLVVGTHALIQGDVKFKQLGLVIIDEQHRFGVRQRAVLRQKGLSPHYLVMTATPIPRTLAMTVFGDLDVTTIQGMPPGRSPIQTRVVTPVGREAAWLFVKQRLAAGEQAYVVYPVIDESDTMQIRAASREFQQLAREVFPDRAVGLLHGRLAADERDRVMKDFLARRIDVLVATTVIEVGIDVPNATVMAIEHAERYGLSQLHQLRGRIGRGDAPGTCLLMTDSRAAADNERLRIMESTQDGFKIAEEDLRLRGPGELIGARQHGLPALHVADLIGDAELLRLAQQDADELLRNDPPLARPAHAALRAALHERHRDALQLVHTG
>NZ_CP036352.1|WP_145129417.1|4177740_4178961_+|redoxin-domain-containing-protein
MGKALKSSIFGAALVAWLGAGIPVLTADEPDVMEIVKKADEATKELTEVSYDAEYFGEGAYAKRVPHVSGKAMLREGKTSMLGALFGGSRQLIRFEGEFSPPDSTVKQSFLVASDGKRVYSLDASEKTYMSAELAAGGDILLRQGATLFMREYIHPTPFSDEINARVQRYEGEKDIGGEPCHVIFVEYSRNQGQARWYFSKNDHLPRRVDRINKTRDGKEAATVLSVSNLNVNPKLTSDLFAPTKPEGFVTRSFEEAGEEPEMLKVGTSAPDFALKTPGGQQVSLAGLRGNVVVLDFWATWCGPCKMAMPGVQRLHEKFADKPVRIFGVNCWERDGDPVEFMKDKKYTYGLLIEGDDVAEKYKVRAIPTFYVIDRAGNVAYAGFYKPGHEDELTAVIEKALKEPEL
>NZ_CP036352.1|WP_145129415.1|4175784_4177566_+|hypothetical-protein
MDRNLHESLDDHTLHPTVRAERLHLALALILAVAAFVRCVGLDALPPPLNADEASRGYDAWALLETGADRHGQRWPFFLESYGPGDFSAALSTYLTIPFIALLGLTPVAMRLPDALLSTCTVLLLFVFVRRHLGDRAALGAALILALDPWHIGLTRTAHESGFAPVFLLMGLLGLDRAGLLGDSEATSEPRAGSNPMIAAAIGGLALAMHTWVYPATRLFTPLFAIAIAVIYRRELRRRMQSPAERGVLLSALTALLIGAIPLIATALRQPEQLAARANITLLSSEDGRLQWARNVTANYWQNVSPRDWYWQCDDMTGVLLPGIGRHLIVTAPAFLLGLIVLLGRVRRDRWAQLLIAWLLLFPLPAAICRDWNPHPMRTVAGMALYPVVCAVGLEAFVAWVNRRRRRVSERIDGSAPLPRAMVAVGATALLVNAAVIGERYVRIITTDGAISYQTALINAMRFAARQSPGDQFILVTNRCVQPYIYALLEEPIAPSRLAALDRVTVPGRLRFDEVLRLGRYYFAPKEPANAMEAMQRFREIWSAVPADSVGLLIARCEEGGVGELLATFKVGQGGQFQDCYGVWRATRSALSD
>NZ_CP036352.1|WP_145129432.1|4190150_4190771_-|DUF2238-domain-containing-protein
MPSTRLHYGLLASFLIVFAWSAIGPHDRFTWMLEVAPTVVAAFVLIATHRRFPLTRLAYLCIWLHAMILLVGGHYTYAEVPLFNWLRDAMGGTRNHYDRVGHFAQGFFPAIIAREVLVRCSPLRPGKWLAFLVTCVCLAISATYELIEWWTALATGEAAEAFLGTQGDIWDTQWDMALALTGAIAAQATLTRLHDRQLAPLARRCP
>NZ_CP036352.1|WP_145129434.1|4190941_4192441_-|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MRRWESCLAAPSVSFVSLGCPKNLVDSEKMLGLIAEAGCPIVSPDDPADVVVVNTCGFLSASREEAVGILRELADQKRAGELKRIVVAGCLVQRDGRGLIGEIPEIDALVGVNNRHDVVRAVLGSKRRSAKSKKTGASAKSRSSASNPRSTASRSLPVVAPDTYLGDYHAASWTEANRSDRARLRLTPTHYAYLRMSEGCNQKCTFCTIPSIRGPMHCKTPDEIMAEARELIDDGALELNLIGQDTTSYGQDLGYEPGLSGLLRMLNTLDGVRWIRLMYAYPSDFTDEMIDAIGQCEKIAPYIDIPLQHINDRVLKAMHRRVTRRETETLLTKLRERIPGVAIRTTFIAGFPGETHAEFQELQRFIAEFGFEAVGVFPYSSEPGTPAHKMKGAIDPDIIEERVGALMRTQQEVAFRRNAAMKGRELLVMIDDFGHMEGPGGISVYPARHAGQAPEVDSVTLVQGGEYDPGEVVRVRITGHRDYDLLAAPVTIGLPVLNG
>NZ_CP036352.1|WP_145129436.1|4192624_4193923_-|MFS-transporter
MIRPYLELPRTVYILALGSFINRAGAFFLVFLTIYLGEHLHLGERFATRTMGVFGAGAIIAAIVGGHLADWLGRKRVMLASLFGGAAVLCAFTALTNPWHLQAAVFAFGFLGEMYRPASTAMVSDVTTTEQRPTAFALLYFSVNLGFAVGPIVGGEVVERFSFSTIFLADAATSATYAIIILLALRETIHLAHAQSLQARSESSPGKSTPGEATPAAASPAADPAPPRIEVGWRQALARLGRDRVFLTFCLATLCISMCFMQHLSTLPLFAREHGIGAKTYGRLIALNGALIVVLQLPFTTLLRRFDRGRMIALSTLIIGAGYGLTAFAHTPTEFAGTIFVWTIGELMQLPFLASVASDLAPADMRGRYMGVFGLCFSSANMIGAPIGGEVLARFGGGYIWAGCFAMGLISGALFLSIRRHISIREATRLIA
>NZ_CP036352.1|WP_145129438.1|4194110_4195910_-|HYR-domain-containing-protein
MAARSSCRGAIRPSCEPCMKSSLRSFLALALCASSLAFGIAGCDLFTQLTGQTADVPIIDQGSIRLVTQNESGLNVDVDATFTVGGVPVRETRLALTPIGPESIKSILRTTAERIDVIARVGAPGAGGNSALTIGTILLKASYVLDVDYVAGGTIYFIVPAPDPAGNPNPICADLGPPTITCPPNVTLPCGSSVVPGLNPALTVAAGVDDCDDEVNVSSSDEVQGDSCSKLIVRTWRVTDNLGKSSFCQQGIVLVDETGPVLTIPADAVVECGDDLSPAATGELIASDGCNDLLQAPTYFDHEPIGDCPKTILRTWTAMDVCGNSTNANQLITVVDTLAPTVDDCPTGDVLTAESGCSISAPDYTGLVSASDACGPGAEASALQLVVTQSPVPGAPLPLGETEIVFTVADACQNTTTCSMYVTVTTGDADEDGVPDCADQCPGYDDTIDCNNNGMPDACEILACDGDPACSDCNENGVPDGCDLAACVGDPACGDCDQNGVPDGCEYYLADCNANALADECEIAHGLAHDLNDNDSPDECDLNGDIDGDGVLNAQDIVAFITCLLQGNAQGPCALADLDGDNDVDFDDLFLFILLFLDP
>NZ_CP036352.1|WP_145129440.1|4196091_4197030_-|hydroxymethylglutaryl-CoA-lyase
MTVSPSCILPRRVRIVEVGPRDGLQNESTPIPTDIKLQFIEKLAAAGLRDIEATSFVHPKAVPQLADAMELARQLPHRDRVTYSALVPNAVGWDRCLQSGIERIAVFTAASESFTAKNIRMTIEESLSVFAPILQDATRRAFTTRAYISTCFECPYEGRVAREKVRDLAERLVEMGAGEIAISDTIGAAAPTDVSDTVGFVLERVPASHIALHFHDTYGTALANVCAGLQLGIATFDSSAGGLGGCPYAPGAAGNLATEDLVYLLDRMGIETGVDLAAVADASAVIGSALGRSPASRNWQRIMQSRCAKANG
>NZ_CP036352.1|WP_145129442.1|4197248_4197818_-|hypothetical-protein
MEQRLMQRVQLIPLAETSAGDAKPLDVAIERANGDAEHDFTVSLGDRRVDVRIDWHDAGAAASRGNLHLHGRLVPFHAIRRDDTIELWMQGRLWRFDVPRRTARRATGADASVASTGRLTAPMPGTVLKVNAAAGDTFAAHQPLIVMESMKMEMALSAPHAGRVAEVCCRAGQLVEMGAVLLRFAENAE
>NZ_CP036352.1|WP_145129444.1|4197802_4199371_-|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MKHFRKILIANRGEIAVRIAATLREMGIAVVAVYSNPDAGALHVRAADEAYPLEGAKSAETYLRGDKIIDIARRCGADAIHPGFGFLSENEDFARACADAMITFIGPTPEVIRDMGDKIVAKAKFAAAGVPIVPGWSGDAHDDFDTIAGHADRIGYPVLIKAAAGGGGKGMRVVKKPEELAAGLESARREATAAFGDGRVFLEKYLVNPRHIEVQIFGDHHGNVVHLFERECSIQRRHQKIIEESPSPALSPALREQICGAAVRAAKAIGYTNAGTVEFILSESGEFYFLEVNTRLQVEHPVTEAVTQRDLVRAQVQVAAGQPLPFRQESIRQIGHAIEARIYAEDASRNFMPSVGVIACYEPPTGPGVRVDSGVERGSEVTVHYDPMLAKLIVHADTRDEAVERMRRALQDYAVLGVTTNVAFLRDVISHSEFRAGRLHTHFLEQHAVRAPDSAPPEEAVIAAALVATAMGAHAATGPGASRTQRAASQRAAGFSPRGFSTPSDSTVADSPWHGVGRWSNV
>NZ_CP036352.1|WP_145129447.1|4199478_4200255_-|enoyl-CoA-hydratase/isomerase-family-protein
MPSFIRIVEQGPIARVTLARPELHNAFNDEMMAELTTAFASLGADARVRLIVLEGEGKSFCAGADINWMKRMVGYTIEENVADANVLAKMLRTIRECPRPTVARVHGATFGGGVGLVAACDMAVATAESMFCLSEVKLGIVPAVISPFVLEKIGAGHARRYALTAERFDGREAHRIGLVSHVVDQPADLDPWIEQIAASVGGNGPMAVAACKRILDRVHGQDWNDVQAFTTRQISEIRVSPEGQEGLKSFLEKRKPNW
>NZ_CP036352.1|WP_145129449.1|4200349_4202926_-|trehalose-phosphatase
MPDLASASGRAPATSSALDERIDALARTPVLLVACDFDGTIAPIVPTPDQAFPDREAIVALGSLAKMPHTHVTVISGRALADLAHRTRDAEDLHLIGSHGSEFEPGFASALSPEATSLRARLLEALSEIAGRYAGTLLEEKPAAAAFHYRGVQDGAARAALEEVFSGPAAWPGVHLRQGKCVVELSVVETNKGTALTRIRHRVAATAALFLGDDLTDEDAFVTLAGPDVGVKVGDGETRAAYRIADTHAAARLLARLAELRFAWLAGSHAVPIEHHAMLSDQRTFALLDSGGRVVWWCVPRLDATTVFAELLGGPAAGFFEITPIDGEAASARAPRYLSDTFVLETAWPGLRLTDYLDAGDGRAYQRAGRSDLLRVIEGRGRVRIRFAPRLDFGRIATRLTVVEDGLVIEGGSDPIILRAPGIAWSLIDDGPHQTAEAELTVNDDPIVLELRYGTGNLSATNMPESDRRRQTELFWSRWAQSLAVPNLHADAVRRSALVLKALTFGPTGSIAAAATTSLPEEAGGVRNWDYRYCWPRDAAMASASLVRLGSTGGAMKFLDWMLGILDHCEAPDRLRPVYTVTGGHLGAEAELTALPGYRGSRPIRIGNAAAGQVQLDVFGPIAELVALLAERGTPLSSEHWRLVEMMVEAVENRWHEPDHGIWEVRMAKRHHVHSKVMCWQTVDRALKVADYLGRKRPQWPALRERIRADVLEHGFNADAGAFTTAYESPEPDAAALWVGLSGMLPPNDPRFLGTIDCIERKLLHGPTVYRYRMDDGLPGAEGGFHICTTWLIEAMAMTGRIDQASGLLNKLVGLIGPTGLLSEQYDPDAAMALGNYPQAYSHLGLIDAVMRLKAAGE
>NZ_CP036352.1|WP_145129451.1|4202935_4204348_-|trehalose-6-phosphate-synthase
MRRPRKKTPRRRAKRRILIVANRLPVMKVRRGGKVHWDPSPGGLVSAMAPVLATHRGEWVGWSGVAGPSPRRLTNDGLRIYPVPLTVADVEKYYLGFSNATIWPLYHDAVRTPVFNARWWKPYVDVNARFARTAAAHAQRGETVWVHDYQLQLVPRMLRELRPDLRIGYFLHIPFPPDELFAWLPWRREILEGLLGADLIGFQTTADARDFSRAAREFTVASGTDSSLQFKGRHIDIGAYPISIDAKWIEQQATEPATLRQAQAIRRSIGASRKLLLSVDRLDYTKGIDQRLRAFELLLRSGDVTVHDCVLMQVAVPSRETVAEYREQRENIERIVGRINGEFSVPGRVPVHYFRRGLSREELVAYYLAADVMVVTPLKDGMNLVAKEYVAARRDNTGVLMLSEFTGAARELRQALLVNPHDIDAMVHTLHAAMELPRSEARTRMAAMRANVRRHDVHAWARNFLRILEG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP036352_3	3.2\|1688007\|27\|NZ_CP036352\|PILER-CR	1688007-1688033	27	NZ_CP035710	Sphaerotilus natans subsp. sulfidivorans strain D-507 plasmid pSna507_unt10, complete sequence	248040-248066	5	0.815
NZ_CP036352_3	3.2\|1688007\|27\|NZ_CP036352\|PILER-CR	1688007-1688033	27	NZ_CP047896	Sphingomonas sp. C33 plasmid pC33, complete sequence	11683-11709	5	0.815
NZ_CP036352_3	3.2\|1688007\|27\|NZ_CP036352\|PILER-CR	1688007-1688033	27	NZ_CP025961	Rhodococcus qingshengii strain djl-6-2 plasmid pDJL2, complete sequence	70826-70852	6	0.778
NZ_CP036352_3	3.2\|1688007\|27\|NZ_CP036352\|PILER-CR	1688007-1688033	27	NZ_KU922118	Starkeya novella strain EL1 plasmid pDCA, complete sequence	22122-22148	6	0.778
NZ_CP036352_3	3.2\|1688007\|27\|NZ_CP036352\|PILER-CR	1688007-1688033	27	CP040467	Streptomyces albidoflavus strain UYFA156 plasmid unnamed, complete sequence	201962-201988	6	0.778
NZ_CP036352_3	3.2\|1688007\|27\|NZ_CP036352\|PILER-CR	1688007-1688033	27	NZ_KU922121	Xanthobacter flavus strain EL8 plasmid pDCA, complete sequence	22120-22146	6	0.778
NZ_CP036352_3	3.2\|1688007\|27\|NZ_CP036352\|PILER-CR	1688007-1688033	27	NZ_CP042333	Bosea sp. F3-2 plasmid pB32-2, complete sequence	122723-122749	7	0.741

1. spacer 3.2|1688007|27|NZ_CP036352|PILER-CR matches to NZ_CP035710 (Sphaerotilus natans subsp. sulfidivorans strain D-507 plasmid pSna507_unt10, complete sequence) position: , mismatch: 5, identity: 0.815

gcatagtcgccgccgccctcggtggag	CRISPR spacer
tagtagtcgccgccgacctcggtcgag	Protospacer
  .************ ******* ***

2. spacer 3.2|1688007|27|NZ_CP036352|PILER-CR matches to NZ_CP047896 (Sphingomonas sp. C33 plasmid pC33, complete sequence) position: , mismatch: 5, identity: 0.815

gcatagtcgccgccgccctcggtggag	CRISPR spacer
gcaaagtcgccgccgccctcgatacgg	Protospacer
*** *****************.*. .*

3. spacer 3.2|1688007|27|NZ_CP036352|PILER-CR matches to NZ_CP025961 (Rhodococcus qingshengii strain djl-6-2 plasmid pDJL2, complete sequence) position: , mismatch: 6, identity: 0.778

gcatagtcgccgccgccctcggtggag	CRISPR spacer
gcattgtcgccgccgccctcggacaca	Protospacer
**** *****************  . .

4. spacer 3.2|1688007|27|NZ_CP036352|PILER-CR matches to NZ_KU922118 (Starkeya novella strain EL1 plasmid pDCA, complete sequence) position: , mismatch: 6, identity: 0.778

gcatagtcgccgccgccctcggtggag	CRISPR spacer
acatagtcgcccccggcctcggtgatc	Protospacer
.********** *** ********.

5. spacer 3.2|1688007|27|NZ_CP036352|PILER-CR matches to CP040467 (Streptomyces albidoflavus strain UYFA156 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

gcatagtcgccgccgccctcggtggag	CRISPR spacer
agaaggtcgccgccgccctcggtgaac	Protospacer
. * .*******************.*

6. spacer 3.2|1688007|27|NZ_CP036352|PILER-CR matches to NZ_KU922121 (Xanthobacter flavus strain EL8 plasmid pDCA, complete sequence) position: , mismatch: 6, identity: 0.778

gcatagtcgccgccgccctcggtggag	CRISPR spacer
acatagtcgcccccggcctcggtgatc	Protospacer
.********** *** ********.

7. spacer 3.2|1688007|27|NZ_CP036352|PILER-CR matches to NZ_CP042333 (Bosea sp. F3-2 plasmid pB32-2, complete sequence) position: , mismatch: 7, identity: 0.741

gcatagtcgccgccgccctcggtggag	CRISPR spacer
acatagtcgccgacgccctcggctaga	Protospacer
.*********** *********. ...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

32976 : 41868

Paracoccus_phage(16.67%)

terminase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_145129635.1\|32976_33372_+	HNH endonuclease	A0A0U2C119	Paracoccus_phage	5.6e-13	54.8
WP_145124413.1\|33822_34380_+	ParB N-terminal domain-containing protein	A0A1B1IPR0	uncultured_Mediterranean_phage	2.2e-23	51.5
WP_145124414.1\|34345_35803_+	DNA (cytosine-5-)-methyltransferase	A0A0R6PHJ5	Moraxella_phage	9.5e-58	52.0
WP_145124415.1\|35712_36660_+	methyltransferase domain-containing protein	A0A2H4IAS4	Erwinia_phage	1.4e-54	47.4
WP_145124416.1\|36778_37246_+\|terminase	phage terminase small subunit P27 family	A0A1B0RXG3	Streptococcus_phage	2.7e-30	42.9
WP_145124417.1\|37361_37949_+	hypothetical protein	NA	NA	NA	NA
WP_145124418.1\|38250_41868_-	hypothetical protein	A0A2H4J643	uncultured_Caudovirales_phage	5.8e-32	27.0

DBSCAN-SWA_2

675331 : 682602

Tupanvirus(16.67%)

terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_145124893.1\|675331_677914_+	tetratricopeptide repeat protein	A0A2K9L5Y0	Tupanvirus	2.6e-18	28.9
WP_145124894.1\|678298_678694_+	HNH endonuclease	A0A0U2C119	Paracoccus_phage	1.9e-13	54.8
WP_145124895.1\|678724_678904_+	hypothetical protein	NA	NA	NA	NA
WP_145124896.1\|679171_679705_+	hypothetical protein	A0A1B1IPR0	uncultured_Mediterranean_phage	3.6e-23	50.5
WP_145124897.1\|679704_681222_+	DNA (cytosine-5-)-methyltransferase	A0A0R6PHJ5	Moraxella_phage	1.1e-56	51.5
WP_145124898.1\|681131_682016_+	methyltransferase domain-containing protein	A0A2H4IAS4	Erwinia_phage	8.6e-54	46.6
WP_145124899.1\|682134_682602_+\|terminase	phage terminase small subunit P27 family	A0A1B0RXG3	Streptococcus_phage	2.7e-30	42.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP036352

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection