CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP042218	Luteimonas sp. Gr-4 chromosome, complete genome	5 crisprs	DEDDh,cas3,csa3,WYL	1	4	0	0

1. NZ_CP042218

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP042218_1

• CRISPR_ID: NZ_CP042218_1
• CRISPR_location: 342953-343122
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_CP042218_1

Consensus_repeat	Method
GCCTTCTTCGCGACTGCCTTCTT	CRISPRCasFinder

spacers of NZ_CP042218_1

>1.1|342976|34|NZ_CP042218|CRISPRCasFinder
TATCGGGATCTTCTTCGCCGCGCTGCCTGCGCCT
>1.2|343033|22|NZ_CP042218|CRISPRCasFinder
GGCGACCGCCTTCTTCGCGACT
>1.3|343078|22|NZ_CP042218|CRISPRCasFinder
CGTGGCGGCCTTCGTCGTGGCG

CRISPR arrays and Neighbor proteins around NZ_CP042218_1

CRISPR arrays

The CRISPR arrays of NZ_CP042218_1

>merge|NZ_CP042218|1|342953-343122|CRISPRCasFinder
ATCTTCTTCGCCGCGGCCTTCTTTATCGGGATCTTCTTCGCCGCGCTGCCTGCGCCTGCTTTCGCCGGCGCGGCCTTCTTGGCGACCGCCTTCTTCGCGACTGCCTTCTTCGCGACTGCCTTCGTCGTGGCGGCCTTCGTCGTGGCGGCCTTCGTCGTGGCGGCCTTCTT

>NZ_CP042218|1|1|342953-343122|CRISPRCasFinder
ATCTTCTTCGCCGCGGCCTTCTT	TATCGGGATCTTCTTCGCCGCGCTGCCTGCGCCT
GCTTTCGCCGGCGCGGCCTTCTT	GGCGACCGCCTTCTTCGCGACT
GCCTTCTTCGCGACTGCCTTCGT	CGTGGCGGCCTTCGTCGTGGCG
GCCTTCGTCGTGGCGGCCTTCTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042218.1|WP_144889631.1|333436_333616_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144889658.1|352468_353293_+|phosphatidate-cytidylyltransferase	unknown	unknown	gnl|CDD|366491
NZ_CP042218.1|WP_144889656.1|351704_352472_+|di-trans,poly-cis-decaprenylcistransferase	unknown	unknown	gnl|CDD|237831
NZ_CP042218.1|WP_144889637.1|339767_340448_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_168198895.1|333092_333266_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144889652.1|350364_351087_+|UMP-kinase	unknown	unknown	gnl|CDD|239787
NZ_CP042218.1|WP_144889650.1|347799_348669_+|elongation-factor-Ts	unknown	unknown	gnl|CDD|236491
NZ_CP042218.1|WP_144893830.1|348828_350301_+|HDOD-domain-containing-protein	unknown	unknown	gnl|CDD|143635
NZ_CP042218.1|WP_144889648.1|346879_347713_+|30S-ribosomal-protein-S2	unknown	unknown	gnl|CDD|235396
NZ_CP042218.1|WP_144889633.1|333619_334198_+|isochorismatase-family-protein	unknown	unknown	gnl|CDD|238245
NZ_CP042218.1|WP_168198896.1|353292_354462_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl|CDD|235472
NZ_CP042218.1|WP_144889639.1|340509_341640_-|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl|CDD|237265
NZ_CP042218.1|WP_144893828.1|337267_339694_+|penicillin-acylase-family-protein	unknown	unknown	gnl|CDD|376618
NZ_CP042218.1|WP_144889635.1|334246_336490_+|DNA-topoisomerase-IV-subunit-A	unknown	unknown	gnl|CDD|235503
NZ_CP042218.1|WP_144889646.1|345789_346563_-|type-I-methionyl-aminopeptidase	unknown	unknown	gnl|CDD|235576
NZ_CP042218.1|WP_144889644.1|343157_345788_-|[protein-PII]-uridylyltransferase	unknown	unknown	gnl|CDD|179839
NZ_CP042218.1|WP_144893826.1|336489_337155_+|thiopurine-S-methyltransferase	unknown	unknown	gnl|CDD|183921
NZ_CP042218.1|WP_144889641.1|341636_341996_-|Spx/MgsR-family-RNA-polymerase-binding-regulatory-protein	unknown	unknown	gnl|CDD|239333
NZ_CP042218.1|WP_144889629.1|332169_333081_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223566
NZ_CP042218.1|WP_144889654.1|351136_351694_+|ribosome-recycling-factor	unknown	unknown	gnl|CDD|178850

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP042218.1|WP_144889658.1|352468_353293_+|phosphatidate-cytidylyltransferase	gnl|CDD|366491	pfam01148, CTP_transf_1, Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.	4.53663e-56
NZ_CP042218.1|WP_144889656.1|351704_352472_+|di-trans,poly-cis-decaprenylcistransferase	gnl|CDD|237831	PRK14836, PRK14836, undecaprenyl pyrophosphate synthase; Provisional.	5.35695e-141
NZ_CP042218.1|WP_144889652.1|350364_351087_+|UMP-kinase	gnl|CDD|239787	cd04254, AAK_UMPK-PyrH-Ec, UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and via gene repression of carbamoyl phosphate synthetase (the first enzyme of the pyrimidine biosynthesis pathway). The UMP kinase of E. coli (Ec) is known to function as a homohexamer, with GTP and UTP being allosteric effectors. Like other related enzymes (carbamate kinase, aspartokinase, and N-acetylglutamate kinase) the E. coli and most bacterial and chloroplast UMPKs (this CD) have a conserved, N-terminal, lysine residue proposed to function in the catalysis of the phosphoryl group transfer, whereas most archaeal UMPKs appear to lack this residue and the Pyrococcus furiosus structure has an additional Mg ion bound to the ATP molecule which is proposed to function as the catalysis instead. Members of this CD belong to the Amino Acid Kinase Superfamily (AAK).	2.82587e-145
NZ_CP042218.1|WP_144889633.1|333619_334198_+|isochorismatase-family-protein	gnl|CDD|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	3.45337e-29
NZ_CP042218.1|WP_144893830.1|348828_350301_+|HDOD-domain-containing-protein	gnl|CDD|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.58612e-57
NZ_CP042218.1|WP_144889648.1|346879_347713_+|30S-ribosomal-protein-S2	gnl|CDD|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	3.99273e-164
NZ_CP042218.1|WP_144889650.1|347799_348669_+|elongation-factor-Ts	gnl|CDD|236491	PRK09377, tsf, elongation factor Ts; Provisional.	2.38235e-133
NZ_CP042218.1|WP_168198896.1|353292_354462_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl|CDD|235472	PRK05447, PRK05447, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional.	0
NZ_CP042218.1|WP_144889639.1|340509_341640_-|succinyl-diaminopimelate-desuccinylase	gnl|CDD|237265	PRK13009, PRK13009, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_CP042218.1|WP_144893828.1|337267_339694_+|penicillin-acylase-family-protein	gnl|CDD|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	3.47257e-98
NZ_CP042218.1|WP_144889635.1|334246_336490_+|DNA-topoisomerase-IV-subunit-A	gnl|CDD|235503	PRK05561, PRK05561, DNA topoisomerase 4 subunit A.	0
NZ_CP042218.1|WP_144889646.1|345789_346563_-|type-I-methionyl-aminopeptidase	gnl|CDD|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.14381e-168
NZ_CP042218.1|WP_144889644.1|343157_345788_-|[protein-PII]-uridylyltransferase	gnl|CDD|179839	PRK04374, PRK04374, [protein-PII] uridylyltransferase.	0
NZ_CP042218.1|WP_144893826.1|336489_337155_+|thiopurine-S-methyltransferase	gnl|CDD|183921	PRK13255, PRK13255, thiopurine S-methyltransferase; Reviewed.	8.22303e-117
NZ_CP042218.1|WP_144889641.1|341636_341996_-|Spx/MgsR-family-RNA-polymerase-binding-regulatory-protein	gnl|CDD|239333	cd03035, ArsC_Yffb, Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.	1.00517e-46
NZ_CP042218.1|WP_144889629.1|332169_333081_-|FAD-dependent-oxidoreductase	gnl|CDD|223566	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones].	9.5776e-47
NZ_CP042218.1|WP_144889654.1|351136_351694_+|ribosome-recycling-factor	gnl|CDD|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	1.94227e-107

Protein sequences

>NZ_CP042218.1|WP_144889641.1|341636_341996_-|Spx/MgsR-family-RNA-polymerase-binding-regulatory-protein
MTTLYGLKNCDTCRKARKWLDRFGVGHVFVDYRDEKPSPETLVDWAGKLGGFEAMVNRSSTTWRELPAHRKAAGSDAEWKLLLREYPQLLRRPVVVTDDGAVTQGFSDNGFKKRFGIDG
>NZ_CP042218.1|WP_144889639.1|340509_341640_-|succinyl-diaminopimelate-desuccinylase
MSEVLALACALIARPSITPDDAGCQALLAGRLLRAGFTCESLRFGAVDNLLATHGEGGPVLLLLGHTDVVPPGPREAWSSDPFVPEERGGMLYGRGAADMKGSVAAFVVALERFVAAHPDHPGTVALLLTSDEEGDAIDGVRRVAEEFRRRGQRIDWCITGEPSSTRRLGDLVRVGRRGSLSAALTVRGVQGHVAYPEKARNPVHRALPALAELVARRWDEGYETFPPTSLQVSNVAAGTGAGNVIPGELRVDFNLRFNPHWTASRLESEIEGLLARHGLDFDLRWHRSGEPFFTPEGPLRATVREAVARTLGVIPEESTGGGTSDARFIAPLGTQCIELGPVNASIHQVDEHVSVADLEALPGLYFALVERLLAR
>NZ_CP042218.1|WP_144889637.1|339767_340448_+|hypothetical-protein
MAIFRSSRLSFLVLGFALASVAATSSAQTVGYNTRTGDVWVDTRLVEINDYGRRHRDPFIDEMHGHYGAPRPLLVELLDRRGWAPGDVYFACAMAHALGIPCLDVVREYDRAPGQGWGAVAKRLGIKPGSDAFHALKRGQVDTYGRWGHTVVIDRPVRVDWSTSGPRRGKAGEGKAGKGPQRDSAGSGPGYQGKRGDAGKAAGQGDKGNGGRGNKGKDRGNNGRGG
>NZ_CP042218.1|WP_144893828.1|337267_339694_+|penicillin-acylase-family-protein
MLSAALAVFVLLAAWCALRGSLPQIDGEAALAGLSAPVSVSRDALGVVTVEAAGETDAMRALGYVHAQERFFEMDLMRRSPAGELSALFGPMALDADRAHRVHRMRARARTAVDAASVAERELLAAYAEGVNAGLGALRARPWAYLLLRARPEPWRAEDSVLVGYAMYFDLHDAANARELALWKIRPHLPQSLYALVTHPGSAWDSPLVGPALGDAVLPAPEILDLRALAAAGDGGADRRSGPTPVEALEPAAPGSNNFAVAGSLTAHGAAIVADDMHLGLRAPGIWFRARLSYSDPRAPGGRIDVSGFTLPGLPAVIVGSNGHVAWGFTNSYGDYLDWALERPCAVRGIAAQRVAAIEPLAPAGKAANAGNPDDCVELAAHRELIGVAGADPVEFVVEESAWGPVMHEADGGRVLSLRWTAHLPGAINLGLLSLSRAADVEQALVLARDIALPSQNLVIGDSGGRIAWRVLGPIPQRGASCEALAPVATTGNAACAPWGMSTRIGPTLASPTADRIWTANSRVVDGAALATIGDGGYVNGARGAQIRDALRAVERFDESALLAIQLDDRALFLQRWHDLLGERARVQGTPALTALAEAGADWDGRASINSTGYRLVRAWRLAVNERIAKGLLAPARDALGEEFTMPALPQLEGVAWPLVTQRPGHLLPAAHASWDALFEDAAVQVRDGLAALGPLAERSWGEANIARICHPLSAALPGRLRRHLCMPADPLPGDVHMPRVQAPSMGASQRMVVAPGREADGIIHQPGGQSGHPLSPFWGAGHADWVQGRPSPFLPGAAAHSLVLAPR
>NZ_CP042218.1|WP_144893826.1|336489_337155_+|thiopurine-S-methyltransferase
MEPGFWHERWREGRIGFHQASVTPQLERHWDALGLPAGSTVFVPLCGKSLDMRWLADRGHRVLGVELSDIAVRDFFAGQGLVPSLQETVFGVHHAAGPFEIIVGDAFALDRETLADCAGVFDRAALIALPPDMRRRYAATTWAALPGGCRGLLVTLEYPQTEKAGPPFAVEAAEVEALFGGDWSPVLLERADILPAEPRFIDAGVSSLTTSVWRLERHPRP
>NZ_CP042218.1|WP_144889635.1|334246_336490_+|DNA-topoisomerase-IV-subunit-A
MNDPVRPAFHGFEQIPLREYAERAYLDYSMYVVLDRALPFIGDGLKPVQRRIIYAMSELGLNAASKPKKSARTVGDVIGKFHPHGDSACYEALVLMAQPFSYRYPLIEGQGNFGSPDDPKSFAAMRYTESKLTPIAEVLLGELAHGTVDWAPNFDGTLEEPTWLPARLPHLLLNGTTGIAVGMATDVPPHNLNEVVSACVRLLDDPDATVADLCEHIRGPDYPTEAEIITPAADLRAMYESGHGSVRARATFVKEGQNIVVTALPYQVSPGKVIEQIAAQMRAKKLPWLEDIRDESDHANPVRVVLIPRSNRIDAGQLMGHLFATTDLEKSYRVNLNIIGRDGRPQVKDLRTLLQEWLSFRADTVTRRLQHRLDKVERRLHLLEGLLVAFLNLDEVIRIIRTEDEPRAVLQARFALSDEQVDYILETRLRQLARLEEMKIRGEQDELDRERDQLIATLGSRAKLRKLIKDELLADAKKFGDARRSPLVARGAAQALAETDLVASEPVTVVLSQKGWVRAAKGHDVDASTLSYREGDALLASVRGRSTHQVAFLDSTGRAYSTLTHGLPSARGNGDPLTGRFSPAPGATFVAMATGEADARFVLASSAGYGFVTRFENLIGRQKAGKAMISLPEGARVLQPAPVASVEGDRIVAATSAGHLLAFPLSELPELDRGKGNKIIEIPKAKRGTERVVSVAAVPEGGSLLVHSGARTMTLSWRDLEAWLGARGSRGGLLPRGWQKVDALSVE
>NZ_CP042218.1|WP_144889633.1|333619_334198_+|isochorismatase-family-protein
MAGRVVPALLIVDMIGLFDFPTADRIAPAAVRAARSIHVLRKRFRERGWPVIYANDNFARWKSDFRELVAMAAATEGAAREIAARLEPGPEDHYLLKPKHSAFLATALPVLLAKLGVRRLLVTGMALESCVLATAIDANAREFEVAVAREAVAGQPALRQSTFRVLEGSKAARLVSASAAEAWCGRPAAADA
>NZ_CP042218.1|WP_144889631.1|333436_333616_+|hypothetical-protein
MSRDRKDLPEDPDKPRHEETPGERRERKHRESENQDEALEETFPASDPTSPFVPAKAPD
>NZ_CP042218.1|WP_168198895.1|333092_333266_-|hypothetical-protein
MPDRERSRDERPGREDRPYPHGTGDRNAWSPTRKNPMPLHEGGTQRKSAPEPAEDGD
>NZ_CP042218.1|WP_144889629.1|332169_333081_-|FAD-dependent-oxidoreductase
MSALIDVIVVGGGPAGLTAASYLRRFHRSCLVLDAGDSRARWIPESNNCPGFPHGVSGAELLRRMREQAFSVDARIEDASVDRIVPCDEGFEVGADARTWRARKVILATGLRDRLPDASWVPEAVACGALRLCAVCDAYEASDQVIGVHGPGDAIGAHAKYLRAYSPAVHALPLDADDGGAAGAEARAAGVEWQSGGGRLEFDGRRCRYVAPDGASVVLDAVYVYLGHDTNAGIAARAGAALTPEGEIIVDGDQKTRLDGLYAIGDVVSGLNQISVAVGHAAIAATHAHNALPFVARKTENPR
>NZ_CP042218.1|WP_144889644.1|343157_345788_-|[protein-PII]-uridylyltransferase
MDAAAPTDAPGRRDDGGDAAWAQARREALAAADAALAARFDQGADATRLAAERARAVDGIVAAAWTRCVPASRGLTLFAVGGYGRGELFPHSDIDLLVLAEEEPDATAGAALSRLFALLWDCGLPASHSVRTLAQCSGAAADLTVMTALLEARPIVADDDAPLALARAIAPDRAWPARDFFIAKAGEKERRHARFGDTSDNLEPNLKEGPGGLRDLQVLGWMARRAFGTHELGPLVALGHVGADEAAALDRERRALGRLRYGLHLVAGRGEDRLRFDHQKALAARLGFADDERTLGVEQMMQGFYRSAAVVRRIGDRLQQRFEEHFDGAAVPEPVDERFELRRGYLAASDNDWPHGDIGEVFALFAAWARLGELRGLHTHTARALAEALDGLPAYTAAPPEQRAGFLELLRGPVPVRTLERMARLGVLGRWIPAFAQVSGRMQFDLFHVYTVDQHTLAVLRNLAAFATGEPDERFSQAHEVYPTLRKPELLLLAGLFHDIAKGRGGDHSELGAVDARTFCAAHGLGEADTALVEWLVLRHLLMSVTAQKQDIADPAVIHRFATEVADRDRLDYLYLLTCADIAGTSPKLWNAWKDRLLADLRSATRLALRRGLENPVAAAERIAEARGTALALLAGHGIDAARAVALLDRFPTASFLRARAEQIAWQALALHESGEAGSQAVVRARLVAPGSPAMEVFVHGPDRDGLFAAIVVTLDRLGLAIQQARALDGPGNTVFDSFQVLPDDARGDCDPKAVARKLGAVLAGPIDDVRPAMRTQPRHLRHFRIVPEVEFATSADHSATVLSLVCTDRPGLLADVAHVLRSEGLRVHDARIATFGARAEDVFRVTGQDKQPLDEAACARLRAALLARIDGEPRR
>NZ_CP042218.1|WP_144889646.1|345789_346563_-|type-I-methionyl-aminopeptidase
MITPKTPEEIEKMRAAGALAAEVLRMIAPHVKPGVSTGELDRLCHEHIVNAQQATPANVGYKGYPRATCISVNNVICHGIPSEAKVLKDGDIINIDVTVIKDGWHGDTSRMYYVGTPSVMAKRLVEVTREAMFHGIRAVKPGATLGDIGHAIQSYAESERFSVVREYCGHGIGRVYHEEPQVLHYGRPGEGLVLEEGMTFTIEPMINEGARHTRLLPDGWTVVTKDRKLSAQWEHTVAVTADGVDILTRLPGDDNDF
>NZ_CP042218.1|WP_144889648.1|346879_347713_+|30S-ribosomal-protein-S2
MPQITMRQMLEAGVHFGHQTRYWNPKMAPYIFGARGKIHIINLEKTVPLFSDAMNFISGIAQKRGMILFVGTKRSAREAIKEEAERCGMPYMTQRWLGGTLTNFRTVKGSVSRLKTLEAGETDGTFDKLVKHEVLGLRREREKLLASLGGIKEMNRLPDALFVIDIGHEDIAIKEARKLGIPVIAVVDTNYDPNLVDYAIPGNDDAIRAVQLYARAAADAVLEGKAAAPSAATVREEEFTEAADGDKPRRAPARKKAEAADAQPAAEAGTDEAKAAE
>NZ_CP042218.1|WP_144889650.1|347799_348669_+|elongation-factor-Ts
MEITASQVKELRERTGAGMMECKKALTEAGGNIDAAAEALRKSGLAKADKKADRVAAEGRVSLAQKGDRAVLVEVNSETDFVAKDENFMQFCEAVADVAVGVDDIEALKAAALGGQTVEEARAALIAKVGENVQVRRMVSMRSGNTIAGYVHGGRIGVLVELEGGDAELARGLAMHVAAMNPPHNKASDVPAEFLAKEKEIELAKMSDKDRAKPADILEKIISGKIAKIVNEVTLYGQPYVLDTDRSVEQVLKAAGAEVVRFERLAVGEGIEKVVEDYAAEVMKQAGLA
>NZ_CP042218.1|WP_144893830.1|348828_350301_+|HDOD-domain-containing-protein
MNRDLEATLRYCRDLFSPPAIALRIIEMARNPETDLAVIARTVSLDPALSQRLLRVSNSSLYAGRRKVETLNQAMTLLGLNATMTLALGFSLARDMRDSAGERAALWCRSVLGSLAARLLGVHVRIDRLEELMLAGLLQDIGAMALLKAIPERYAPLRARAPDNTALLALEREAFGCDHAEVGAWLARQWELPQYLQDAIAASEDPSAEDPFAACVIASGAIAELWLDRAGGASEARARALVQALPLHEGTTLDTVLAEMHASLPEISTLFETQIPHADHLDGLIAEARELLVMRNLRMIQSAAASRRDADKAAEHIRRLAEQARRDPLTGVYNRLEMDEALEREFALALELGQPLSVAFIDLDEFKRINDEHGHLVGDQVLRQFATSLQEMLRANDIVARYGGEEFLVVLGNSGQAAATMILQRILEQVRRLPMATVDDRPLYVTFSAGIATHDADTRFPDAGSILRAADEALYGAKRDGRNRVGRRPS
>NZ_CP042218.1|WP_144889652.1|350364_351087_+|UMP-kinase
MATLAYRRILLKLSGEALMGDEDYGIDPKVIQRLAAEIIEAQAAGAEIALVIGGGNIFRGAGLAAGGMDRVTGDQMGMLATVINALAMQDALEKLGAKVRVMSALKINDVCEDYIRRRAIRHLEKGRITIFAAGTGNPFFTTDSGAALRAIEIGADLLLKATKVDGVYDSDPKKNPDATRYERLTYDEVIGRDLQVMDTAAFALARDSDLPLRIFDMEQPGQLLRILKGEPIGTLVQGRG
>NZ_CP042218.1|WP_144889654.1|351136_351694_+|ribosome-recycling-factor
MLNEIKKDAQARMAKSVESLRHDLTKVRTGRASTALVDHLRVNYYGSDMPLTQVASVTVSDARSLTITPWEKQMVAAVEKAILASDLGLTPNTAGTTIRINLPALTEERRRELTKLVHSEGESAKVAIRNIRRDANQQAKDLLKEKAISEDDERRFETEVQKITDDAIKDVDEVVKAKEQELMAV
>NZ_CP042218.1|WP_144889656.1|351704_352472_+|di-trans,poly-cis-decaprenylcistransferase
MSAPSTTLQGTPRHVAIIMDGNGRWAARRRRPRMIGHRAGARAVNLCIDFCLERGVGALTLFAFSSENWGRPADEVGALMKLFLNALDREVDELHRRGVRVRFIGERGRFDAGIVARMDAAERLTADNAGLALSIAASYGGRQDIAAAARALAVEVAEGRMRPQDIDETAMARHMALADLPPPDLFIRTGGDLRISNFLLWQLAYTELWFTDLLWPDLDAATLQRAFDDFAARERRFGLTGGQVASEPTTDTNAP
>NZ_CP042218.1|WP_144889658.1|352468_353293_+|phosphatidate-cytidylyltransferase
MTRIRVLAALVMAPAAIATVLLLPTPWLMLITAIVFLAALWEWFALAEVEDSLARSALLVLNLLLMVALVWGTGGTGATLVLFKVAVVLGVLWWLLAMLWLVHFDFASDHDTNGRVYKLAAATFAVVPAWCAMALLHNDGPGWLLLALMVVWGTDTGAYFAGRRFGRRKLAPRISPNKTVEGLVGGTAVGVLVALVGAWILGVAPAQLPLVALVALLAVLFSVVGDLFESLLKRHVGAKDSGNLIPGHGGIMDRADSVLAALPVFALGKIWLGF
>NZ_CP042218.1|WP_168198896.1|353292_354462_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MRRVAVLGATGSIGRSALDVIARHPGAMRASVLAAGSQVDALLEACRRHRPDDAAIADESAWPRLRDGLRDAGLPTRAHAGKDAIAALAGGDGCDTVVAAIVGAAGLDSTLAAARAGKRLLLANKESLVLAGELVMATARDHGARVIPIDSEHNAIFQCLPPDGACDDVRRLVLTASGGPFRGRDRASLADVTPAQAVAHPKWSMGPKISVDSATLMNKGLEVIEAHHLFGLPAARIDVLVHPQSLVHSLVEFVDGSTLAQLGLPDMRTALAVGLGWPRRIESGVGGLDLLAQSRLDFEAPDTDAFPCLALAFGALEAGGTAPAVLNAANEEAVSAFLQGRIAFLSIPALVEDALAALPARPAASLEALREADALARDTTRRALARYAR

Crispr_ID: NZ_CP042218_2

• CRISPR_ID: NZ_CP042218_2
• CRISPR_location: 799572-799652
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP042218_2

Consensus_repeat	Method
AGGAGCGGCTACAGCCGCGAATGC	CRISPRCasFinder

spacers of NZ_CP042218_2

>2.1|799596|33|NZ_CP042218|CRISPRCasFinder
AGGGTCCGCAGCCATTCCATGGCACGAACCTGT

CRISPR arrays and Neighbor proteins around NZ_CP042218_2

CRISPR arrays

The CRISPR arrays of NZ_CP042218_2

>merge|NZ_CP042218|2|799572-799652|CRISPRCasFinder
AGGAGCGGCTACAGCCGCGAATGCAGGGTCCGCAGCCATTCCATGGCACGAACCTGTAGGAGCGGCTATAGCCGCGAATGC

>NZ_CP042218|2|2|799572-799652|CRISPRCasFinder
AGGAGCGGCTACAGCCGCGAATGC	AGGGTCCGCAGCCATTCCATGGCACGAACCTGT
AGGAGCGGCTATAGCCGCGAATGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042218.1|WP_144890421.1|787095_787956_+|DUF72-domain-containing-protein	unknown	unknown	gnl|CDD|376655
NZ_CP042218.1|WP_144890444.1|803380_803620_+|type-II-toxin-antitoxin-system-ParD-family-antitoxin	unknown	unknown	gnl|CDD|281658
NZ_CP042218.1|WP_144893901.1|783989_784823_+|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|238194
NZ_CP042218.1|WP_144890438.1|800355_801837_-|DNA-polymerase-Y-family-protein	unknown	unknown	gnl|CDD|176458
NZ_CP042218.1|WP_144890459.1|805197_806298_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP042218.1|WP_144890427.1|789070_789970_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|182990
NZ_CP042218.1|WP_144890456.1|804812_805196_-|fluoride-efflux-transporter-CrcB	unknown	unknown	gnl|CDD|223317
NZ_CP042218.1|WP_144890424.1|788040_788952_-|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
NZ_CP042218.1|WP_144890435.1|791757_793524_+|DUF2207-domain-containing-protein	unknown	unknown	gnl|CDD|378333
NZ_CP042218.1|WP_144890441.1|802569_803190_-|transcriptional-repressor-LexA	unknown	unknown	gnl|CDD|171489
NZ_CP042218.1|WP_144890419.1|785387_786977_-|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NZ_CP042218.1|WP_168198924.1|801844_802573_-|translesion-DNA-synthesis-associated-protein-ImuA	unknown	unknown	gnl|CDD|380271
NZ_CP042218.1|WP_144890450.1|803926_804526_-|hypothetical-protein	unknown	unknown	gnl|CDD|379149
NZ_CP042218.1|WP_144890447.1|803616_803916_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|226194
NZ_CP042218.1|WP_144893909.1|806307_806706_-|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl|CDD|225039
NZ_CP042218.1|WP_144893903.1|793543_795376_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224055
NZ_CP042218.1|WP_144890416.1|784915_785212_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144890433.1|790984_791212_+|RNA-binding-S4-domain-containing-protein	unknown	unknown	gnl|CDD|379097
NZ_CP042218.1|WP_144890430.1|789996_790938_+|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
NZ_CP042218.1|WP_144890453.1|804512_804716_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP042218.1|WP_144890421.1|787095_787956_+|DUF72-domain-containing-protein	gnl|CDD|376655	pfam01904, DUF72, Protein of unknown function DUF72. The function of this family is unknown.	1.86249e-63
NZ_CP042218.1|WP_144890444.1|803380_803620_+|type-II-toxin-antitoxin-system-ParD-family-antitoxin	gnl|CDD|281658	pfam03693, ParD_antitoxin, Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH. ParD is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is ParE in, pfam05016. The family contains several related antitoxins from Cyanobacteria, Proteobacteria and Actinobacteria. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerizes with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all type II antitoxins.	1.17145e-24
NZ_CP042218.1|WP_144893901.1|783989_784823_+|peptidylprolyl-isomerase	gnl|CDD|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	4.60798e-29
NZ_CP042218.1|WP_144890438.1|800355_801837_-|DNA-polymerase-Y-family-protein	gnl|CDD|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	2.57543e-68
NZ_CP042218.1|WP_144890459.1|805197_806298_-|alpha/beta-fold-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.60961e-15
NZ_CP042218.1|WP_144890427.1|789070_789970_+|LysR-family-transcriptional-regulator	gnl|CDD|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	2.82553e-79
NZ_CP042218.1|WP_144890456.1|804812_805196_-|fluoride-efflux-transporter-CrcB	gnl|CDD|223317	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning].	6.85809e-29
NZ_CP042218.1|WP_144890424.1|788040_788952_-|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	7.36882e-21
NZ_CP042218.1|WP_144890435.1|791757_793524_+|DUF2207-domain-containing-protein	gnl|CDD|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	1.30478e-61
NZ_CP042218.1|WP_144890441.1|802569_803190_-|transcriptional-repressor-LexA	gnl|CDD|171489	PRK12423, PRK12423, LexA repressor; Provisional.	1.63004e-90
NZ_CP042218.1|WP_144890419.1|785387_786977_-|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	4.85061e-61
NZ_CP042218.1|WP_168198924.1|801844_802573_-|translesion-DNA-synthesis-associated-protein-ImuA	gnl|CDD|380271	NF033429, ImuA_translesion, translesion DNA synthesis-associated protein ImuA. A three-gene cassette encoding ImuA, ImuB, and ImuC (""inducible mutagenesis"") is induced by DNA damage, is capable of DNA synthesis across DNA damage lesions, and consequently is associated with mutagenesis. This family, ImuA (previously misnamed SulA in Pseudomonas putida) shows some homology to SulA itself and to RecA. ImuB resembles Y-family polymerases but may be catalytically inactive. ImuC is a C-family polymerase, and catalytically active.	7.74025e-77
NZ_CP042218.1|WP_144890450.1|803926_804526_-|hypothetical-protein	gnl|CDD|379149	pfam13376, OmdA, Bacteriocin-protection, YdeI or OmpD-Associated. This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.	2.25959e-17
NZ_CP042218.1|WP_144890447.1|803616_803916_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|226194	COG3668, ParE, Plasmid stabilization system protein [General function prediction only].	4.95182e-20
NZ_CP042218.1|WP_144893903.1|793543_795376_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.40744e-161
NZ_CP042218.1|WP_144890433.1|790984_791212_+|RNA-binding-S4-domain-containing-protein	gnl|CDD|379097	pfam13275, S4_2, S4 domain. The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.	1.57042e-25
NZ_CP042218.1|WP_144890430.1|789996_790938_+|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.16038e-10
NZ_CP042218.1|WP_144893909.1|806307_806706_-|carboxymuconolactone-decarboxylase-family-protein	gnl|CDD|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	8.25826e-15

Protein sequences

>NZ_CP042218.1|WP_144893903.1|793543_795376_+|ATP-binding-cassette-domain-containing-protein
MFGWFESRLEPFPDAPPRQPPRGLVAFCLHYTRGAGGWLSLMALTGALIAIGELGLYVYLGALVDRLGEHTPASFLEAEGTRLAWMALLVAVGLPLLVWLDNLVQLQVLLGNFPMRIRWNVHRYLLRQSMGYFQDEFAGRIATKLMQTSLAVRETVIKLMDVGVYVSVYVVGAMVAMAATDWRLMLPFAGWAAGYGALMVYFVPRMERVSREQADARSDMTGRIVDSYTNIATVKLFSHSRREQAYAREAMDGFLGTVYRQMRLATGVSAGNYALNMALVFAVSAIGLWLWRGDAISAGAVAVGVALALRLVGMSQWIMWELSALFENVGTVQDGINSISLPPTVDDAPGAPELRVVKGDIRFEGVAFHYGKGSGVIERLDLHVRPGERIGVIGRSGAGKSTLVNLLLRFHDVEAGRILVDGVDIASVQQDSLRACIGVVTQDTSLLHRSVRENILYGRPDASEEEMVEAARQAEAHDFILELSDAAGRRGYDAQVGERGVKLSGGQRQRIAIARVLLKDAPILVLDEATSALDSEVEAAIQGNLYRLMEGKTVIAIAHRLSTIAAMDRLVVMDQGAIVEQGTHGELVARGGIYAQLWRHQSGGFLAEVP
>NZ_CP042218.1|WP_144890435.1|791757_793524_+|DUF2207-domain-containing-protein
MTGRRRPAAVFGWLFAAAMVLLPGLAAADERILAYDSMVEVRADGSLEVTEHIRVRAEGSDIRRGIYRDFPTRYRDRDGNRVVVGFEVLGVERDGRPEPWFTGSVSNGVRVNTGNDDVLPVPLETTYTLRYRTTRQLGFFEGHDELYWNAIGHGWAFPIDSGSVEVRLPTPVPANALVAEGYSGPQGAREQGFEATIAGPGVARWTLVRPLRPREGLTIVLSFPKGIVTPPSRADEARWLLADNLSLGAALAGLLALLAYCLKRWRAVGRDPEPGVIIARYEPPRGESPGALRYMARRGHDHICMSADLLACAVQGALHIDHDRGMLGDRWTLRRGDVPAADLANADQRRLLEALLPPSRPSLELGKENARHLLEARTRHGEGMKRRFQPAMFSHNGGSIAIAFAIFFVTVVATLLLVAAGDGGGMPWALAPLGLAFAVALAFAFAIGAPTPEGRRLLDEIEGFKRYLSVAEQDDLARLAGPASAEPPPLDAARFEALLPYAVALGVEKAWTGKFTAAVGTAAAAAATAGIAWYHGSGGADIGRFTSSIGSALSSQIASSSTPPGSSAGGGGGGFSGGGGGGGGGGGR
>NZ_CP042218.1|WP_144890433.1|790984_791212_+|RNA-binding-S4-domain-containing-protein
MQHIDFELEGDFVELNQLLKLAGLCDSGGAGKALVASGAVRVDGAVESRKTAKIRAGQIVALGDVEVRVHAGAGP
>NZ_CP042218.1|WP_144890430.1|789996_790938_+|EamA-family-transporter
MTPTTRAQLQIHLCVLLWGFTAILGKLITLPALPLVWWRMLLVVAALALLPRVWRGVRALPRRLLLAYAGIGVLVALHWLTFYGAVKLANASVAATCMALATVFVAMIEPKLAKRRFSRAELALGIAVLPGVALVVGGIPDGMRIGVAVGALSALFVALFGSLNKRLVEHADPLVVTAVELGAGAIALTLLAPVMPYVFPAFAGPLFVLPGAQDAAWLLLLAFACTLFPFALSLVALRHMSAFSAQLAVNLEPVYAIVLAIVLLSEQQELSLPFYLGVVIILAAVLVHPVLARPQRISHPETLATGEARDVTD
>NZ_CP042218.1|WP_144890427.1|789070_789970_+|LysR-family-transcriptional-regulator
MTLRSDWLPALAAFEAAARHQNFAHAGEELHLTASAVSHHVRKLEARLGVMLFQRHARGVSLTAEGRRLADASGNALAELEDVLSGLRTSQGDGERVRVTALHSFTTAWIVPRLPDFAARHPDIRISFETEIALTRFDDQGPDLGVRHGPGHWPGLSAQRLLEEPLFPVASPALAGVDRIADPADIARLPLVGDLSRHGWSDWFRAAGVRGARPMERFTFSDSTDMLEAAAHGLGAALARRLVVVPWLASGRLLRLPGPELPSRYAYFIVHPSHRPLRPAARLFAEWLMDMAADALPGR
>NZ_CP042218.1|WP_144890424.1|788040_788952_-|EamA-family-transporter
MNSLPGRAAPASPSAPGALSAWMTPLEITLLGAIWGASFLFMRIAAPQFGAVPLVELRLGLGALVLLPFLWRSRAAFPPALWPKLALIGAINSALPFILFAWAAERAPAGIGAIANAMTVLFTALVAFLFFGEKIGRRRAVALFAGFAGVVVLASGKSAGVSVGWAVVAGGLASFLYGVGLNLVKRHLTGLPPAAVAAATLGCSALLVLPFAVATWPSQPVTPAAWTSAVALGVLCTGAAFVMYYRLIARIGPTRASTVTYLIPVFGVAWAWWLLGEPVTWTMAVAGATILGSVAFSQRGGAR
>NZ_CP042218.1|WP_144890421.1|787095_787956_+|DUF72-domain-containing-protein
MARSTATDAPIEGLAEAGVPPVDGIRTGIGGWTFAPWRDNFYPKGLVQRRELEYASRRLSAIEINGTWYGAQKPATYAKWRDDTPPGFMFSAKAPMRITQSRALAKTGTQVEDFVGGIAELGDRLGPLVWQFDRGTRPDRAEFAAFLDLLPREAGGRPLRHVLDVRDPDFVDAGYIALARSQGMATVFTDSPEHPSFADVTAGFVYARLMRARAGSATGYPRDELEQWAGRVRTWAAGGEPDDLPRIDPQQVPSPVARDVFVFFIAAAKERNPAAAMALHALLEAR
>NZ_CP042218.1|WP_144890419.1|785387_786977_-|serine-hydrolase
MTKRVAAVLSLLLSFSTPAIAQQAPPPELARLDAHVEAVRETFRVPGIAVAVIKDGDVVLARGWGQREVGGAEPVDGDTLFSIASITKAFTSAALSILADEGRLAMDDRVIDHLPWFRMSDAYVTREMRIRDLLVHRSGLGLGAGDLLFWPPSDYSTRDVVRRLAQVPIEGGFRDRYAYDNVLYAVAQLVIEEVSGQSYGDFVRERLFEPVGMVDTRIDSNALRPGDTNVATGHARPGFTGDPVPVPHMSWSNNTAAGGIYSSVNDLAKWMRVQLDGGVLEGEGEKAKRLFSAKRHEAMWSLVTPIPIREPAVPELAATKPNFAGYGEAWSLSDYRGRRLVWHTGGWPGMVSRLTLVPELGLGVVVLTNQEAGAAFNAVTMHVLDAYMEAPATDWVAAYAAAVGKGSDREAEDWKKHLAARDARSKPSLPLSGYAATYRDPWYGDVVVAAGRKGLEMRFSRTPQLVGDLEHWQHDSFIVRWRDRTLNADAFVDFSLDHDGKVREARMEAVSPLTDFSFDFHDLRLAPVE
>NZ_CP042218.1|WP_144890416.1|784915_785212_+|hypothetical-protein
MPMLRIRLTGSDDTARAVMNLLQSLDGIEHVEEIDDLMPQLDDADSSSAGLSDVEGPQGHTIEIDAPNPSTARRVRDAVEALAFDLDAVVEFEEDDEE
>NZ_CP042218.1|WP_144893901.1|783989_784823_+|peptidylprolyl-isomerase
MRPRTTQELLDASTPADWRRPDPASTLYMELEGGRVVIELAPDFAPEHVANIRTLAKEGFWDGLTIYRSQDNFVVQFGDITGEGEAPKPIGGARAALPAEFSRPIEGLAFHALPDRDGWAPETGFAGGFPAARDPAEGQAWMAHCYGTLGAGRDMAADSSNGTELYVVIGQAPRQLDRNITQVGRVLHGMELLSVVPRGTGPLGFHEDPSQRVPIKAVRLASEVPETERTDLQVLRTDTPLFDAVVESRRNRRDDWYLRPAGHIDLCNIAVPVRVVD
>NZ_CP042218.1|WP_144890438.1|800355_801837_-|DNA-polymerase-Y-family-protein
MLWACIALPRLALDAVLRRVPDPSRPLALVSGPAQLRHLHAVNAAAAEAGLKPGMRLSAAHALLSDVAMVEYDPASEARWQRFLAAWAYRHSSQVSARWPGAIVLEVRASFRLFGPWPRFEARLREELEGLGFSHRIALAPTPRAARVFAGLRDGFAVTGEGAMREALARVPVRRAALPGNAGERLQRMGVHTLGDLRMLPRDGLRRRFGVELLEHLDRLHGDADDPLALYAPPDHFDGRIDLGFEVESHQALLFPLRRLIVDLATYLSARDGGVQRFTLRLEHEARHALPSHEADQVQHDAVRFTEVPVGLLAAERDAGLLFELTRNRLEQVALPAPVIGLRLLARELPPFVPAERDLFDTRPAQAVPWPQLRERLRARLGDEAVHRVAPSGDPRPERAWRRADAGEDGDAACLAPAPRRPPRPAWLLPRPVPLRDPRLRIVSGPERLESGWWDGDDARRDYYVLETSRGQRAWAFAPPGEREGWMLHGWFA
>NZ_CP042218.1|WP_168198924.1|801844_802573_-|translesion-DNA-synthesis-associated-protein-ImuA
MNALPAIAMPPIAALPGLDAMLSARTVWRAGRAPVVRPDGEPTGYAALDALLPQGGWPRAALTELLLPADGVGELSLLLPTLARLTQAGGIVALVAPPYLPYAPAWQAAGVDLRHLEVIEADARGALWAFEQCLRSAACAAVLGWPLQADAQALRRLQVAADSGDSLGFAFRDAKHAANPSPAALRMEYSAAGEGGWHIRKCRGANPPSQSFVPHRPVGAAIAAIPTRGAIAAIAAPTVPFS
>NZ_CP042218.1|WP_144890441.1|802569_803190_-|transcriptional-repressor-LexA
MTDDLTPRQRDVLGFIQAHAGAEGAPPTLQQIADAFGFRQACAAHKHVRRLQQAGYLEVRPNEARGIRVIGGTRLKVRDDRLELPVLGRVAAGAPIGADAGIERHLLFDRALFSSRPDYLLRVKGDSMRDDGIFDGDLVAVQRASDARNGQVVVARIDGEITIKRLERTRSRLRLLPRNPDYAPIEVPPGSDFAIEGIYCGLVRAE
>NZ_CP042218.1|WP_144890444.1|803380_803620_+|type-II-toxin-antitoxin-system-ParD-family-antitoxin
MAKNTSVSLGDHFEEFIGSQIDSGRYGSASEVVRAGLRLLETAENRLEVLRQALREGERSGRADYSYESLVSELDAERP
>NZ_CP042218.1|WP_144890447.1|803616_803916_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MSSFGLTRAARADLKSIARLTEARWGVRQRNAYLKEVDRIFHALARNPAMGRACDDILQGYRRLPHGAHVIYYRQIAGQEVMIVRILHGAMDAEAYLDT
>NZ_CP042218.1|WP_144890450.1|803926_804526_-|hypothetical-protein
MTRHDPRIDAYIARQADFARPILEELRRRVRAACPEAVETIKWGAPAFTYRDKLLGVMAGFKQHAAFNLWHGKQIVGEDAAVQEGMGQYGRITSLKDLPAKRETTAHIRAAMALVEAGTTTATARAPKPPPSLPDDLAAAMRGNKAARGHWDAFTPGKQREYADWIMGAKGADTRARRVAQAVEWIAEGRTRNWKYAKC
>NZ_CP042218.1|WP_144890453.1|804512_804716_-|hypothetical-protein
MTADEPLDFAALERLQLQQWVALSTAAKVDFFEEMIQLAYSSGALRPEQLALRDKASPPSGDHHDPP
>NZ_CP042218.1|WP_144890456.1|804812_805196_-|fluoride-efflux-transporter-CrcB
MHPVLLVGLGGFLGAVARYKLGGLVLHLTVQERFPFSTFAVNVLGCLVVGVLAGLAERHQAFGPDARLFLFTGLLGGFTTFSAFGLEAVYLLRRGELATAALYAGGSVVLGIAAVWLGLKLVGLGSR
>NZ_CP042218.1|WP_144890459.1|805197_806298_-|alpha/beta-fold-hydrolase
MTRLLAALLLLALPLLAHGQPACPSGESFDKARAVVADLQRIVTPAGVQDTYAERIGGIDQWMQVRGKDRANPMILFVHGGPSSPAMPSAWQWQRPVEEFFTIAHYDQRGAGKTHRANDPDAVAGDMAIGRFVDDAIEVAEHLRARYGKDKLVLAGHSWGTVVAMHAALRRPDLFHAYVGIGQVIDTRRNERLSFEYGLERARVEGNAAAVAELESIAPYPGDAPITRERIIIARKWPQHYGGLNAYRDAEQDYYYGASLLSPAYDCEDRRAFFAGNVFTLEHVLDEFLQVDFSGVREFPIPVVMFLGRHDYTTPSAPTVEWLEQVRAPYRRAVWFEHSAHMIPWEEPGRTLLALLEHVRPLAVEP
>NZ_CP042218.1|WP_144893909.1|806307_806706_-|carboxymuconolactone-decarboxylase-family-protein
MLELEQRMSAAVAAAGLADGFAHLLRLRASQINKCAYCVRMHARDALACGESADRLALVAAWEEAGCFDARERAALALVEAITLVAADQVPDAVYAQAVAVLSGEEIAAVEWLAVVINAWNRIAIAGRTVEP

Crispr_ID: NZ_CP042218_3

• CRISPR_ID: NZ_CP042218_3
• CRISPR_location: 1579489-1579563
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP042218_3

Consensus_repeat	Method
CGGGGCCGCCGCGACATCCATCGC	CRISPRCasFinder

spacers of NZ_CP042218_3

>3.1|1579513|27|NZ_CP042218|CRISPRCasFinder
TCCTGCAGGAGCGGCTACAGCCGCGAT

CRISPR arrays and Neighbor proteins around NZ_CP042218_3

CRISPR arrays

The CRISPR arrays of NZ_CP042218_3

>merge|NZ_CP042218|3|1579489-1579563|CRISPRCasFinder
CGGGGCCGCCGCGACATCCATCGCTCCTGCAGGAGCGGCTACAGCCGCGATCGGGGGCGCCGCGACATCCATCGC

>NZ_CP042218|3|3|1579489-1579563|CRISPRCasFinder
CGGGGCCGCCGCGACATCCATCGC	TCCTGCAGGAGCGGCTACAGCCGCGAT
CGGGGGCGCCGCGACATCCATCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042218.1|WP_144891702.1|1584076_1585273_+|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NZ_CP042218.1|WP_144891678.1|1564840_1566736_-|exodeoxyribonuclease-V-subunit-alpha	unknown	unknown	gnl|CDD|273631
NZ_CP042218.1|WP_144891698.1|1581920_1583087_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|224017
NZ_CP042218.1|WP_144891682.1|1570358_1573739_-|exodeoxyribonuclease-V-subunit-gamma	unknown	unknown	gnl|CDD|273633
NZ_CP042218.1|WP_144891691.1|1578010_1578307_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|225655
NZ_CP042218.1|WP_144891700.1|1583214_1583997_+|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl|CDD|366759
NZ_CP042218.1|WP_144891686.1|1575154_1576042_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224052
NZ_CP042218.1|WP_144891712.1|1588283_1588574_-|mitomycin-resistance-protein	unknown	unknown	gnl|CDD|371697
NZ_CP042218.1|WP_144891680.1|1566732_1570362_-|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|224000
NZ_CP042218.1|WP_144891690.1|1577355_1578030_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|377516
NZ_CP042218.1|WP_144891704.1|1585302_1587000_+|M28-family-peptidase	unknown	unknown	gnl|CDD|349910
NZ_CP042218.1|WP_144891695.1|1579616_1580996_-|DNA-recombination-protein-RmuC	unknown	unknown	gnl|CDD|224241
NZ_CP042218.1|WP_144891688.1|1576041_1576791_+|MlaE-family-lipid-ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223838
NZ_CP042218.1|WP_144891710.1|1587756_1588152_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144891708.1|1587484_1587760_-|DUF4242-domain-containing-protein	unknown	unknown	gnl|CDD|379428
NZ_CP042218.1|WP_144891696.1|1581049_1581403_+|DUF488-family-protein	unknown	unknown	gnl|CDD|225730
NZ_CP042218.1|WP_144891693.1|1578329_1579451_+|VacJ-family-lipoprotein	unknown	unknown	gnl|CDD|377309
NZ_CP042218.1|WP_144891684.1|1573759_1574437_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144891706.1|1587059_1587365_-|hypothetical-protein	unknown	unknown	gnl|CDD|341493
NZ_CP042218.1|WP_144894023.1|1576825_1577359_+|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	unknown	unknown	gnl|CDD|275223

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP042218.1|WP_144891702.1|1584076_1585273_+|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.42155e-60
NZ_CP042218.1|WP_144891678.1|1564840_1566736_-|exodeoxyribonuclease-V-subunit-alpha	gnl|CDD|273631	TIGR01447, recD, exodeoxyribonuclease V, alpha subunit. This family describes the exodeoxyribonuclease V alpha subunit, RecD. RecD is part of a RecBCD complex. A related family in the Gram-positive bacteria separates in a phylogenetic tree, has an additional N-terminal extension of about 200 residues, and is not supported as a member of a RecBCD complex by neighboring genes. The related family is consequently described by a different model. [DNA metabolism, DNA replication, recombination, and repair].	6.6984e-172
NZ_CP042218.1|WP_144891698.1|1581920_1583087_-|methyltransferase-domain-containing-protein	gnl|CDD|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	3.35897e-136
NZ_CP042218.1|WP_144891682.1|1570358_1573739_-|exodeoxyribonuclease-V-subunit-gamma	gnl|CDD|273633	TIGR01450, recC, exodeoxyribonuclease V, gamma subunit. This model describes the gamma subunit of exodeoxyribonuclease V. Species containing this protein should also have the alpha (TIGR01447) and beta (TIGR00609) subunits. Candidates from Borrelia and from the Chlamydias differ dramatically and score between trusted and noise cutoffs. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP042218.1|WP_144891691.1|1578010_1578307_+|STAS-domain-containing-protein	gnl|CDD|225655	COG3113, COG3113, Predicted NTP binding protein (contains STAS domain) [General function prediction only].	1.42602e-11
NZ_CP042218.1|WP_144891700.1|1583214_1583997_+|rhomboid-family-intramembrane-serine-protease	gnl|CDD|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	2.59533e-16
NZ_CP042218.1|WP_144891686.1|1575154_1576042_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224052	COG1127, Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	1.58913e-116
NZ_CP042218.1|WP_144891712.1|1588283_1588574_-|mitomycin-resistance-protein	gnl|CDD|371697	pfam11731, Cdd1, Pathogenicity locus. Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.	6.38111e-39
NZ_CP042218.1|WP_144891680.1|1566732_1570362_-|UvrD-helicase-domain-containing-protein	gnl|CDD|224000	COG1074, RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair].	0
NZ_CP042218.1|WP_144891690.1|1577355_1578030_+|ABC-transporter-substrate-binding-protein	gnl|CDD|377516	pfam05494, MlaC, MlaC protein. MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. This family of proteins is involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation. Many proteins are involved in these processes.	3.04897e-46
NZ_CP042218.1|WP_144891704.1|1585302_1587000_+|M28-family-peptidase	gnl|CDD|349910	cd05660, M28_like_PA, M28 Zn-peptidase containing a protease-associated (PA) domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	1.6972e-77
NZ_CP042218.1|WP_144891695.1|1579616_1580996_-|DNA-recombination-protein-RmuC	gnl|CDD|224241	COG1322, COG1322, Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only].	3.1844e-94
NZ_CP042218.1|WP_144891688.1|1576041_1576791_+|MlaE-family-lipid-ABC-transporter-permease-subunit	gnl|CDD|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	3.32273e-67
NZ_CP042218.1|WP_144891708.1|1587484_1587760_-|DUF4242-domain-containing-protein	gnl|CDD|379428	pfam14026, DUF4242, Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	2.09553e-26
NZ_CP042218.1|WP_144891696.1|1581049_1581403_+|DUF488-family-protein	gnl|CDD|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	5.10309e-43
NZ_CP042218.1|WP_144891693.1|1578329_1579451_+|VacJ-family-lipoprotein	gnl|CDD|377309	pfam04333, MlaA, MlaA lipoprotein. MlaA is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. MlaA is required for the intercellular spreading of Shigella flexneri. It is attached to the outer membrane by a lipid anchor.	3.73722e-97
NZ_CP042218.1|WP_144891706.1|1587059_1587365_-|hypothetical-protein	gnl|CDD|341493	cd17808, HipA_Ec_like, type II toxin-antitoxin sytem toxin HipA from Escherichia coli and similar proteins. This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Escherichia coli HipA, a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. In the Escherichia coli HipAB:DNA promoter complex, HipA forms a dimer and each HipA monomer interacts with a HipB homodimer which binds DNA. The HipAB component of the complex is composed of two HipA and four HipB subunits.	0.000244578
NZ_CP042218.1|WP_144894023.1|1576825_1577359_+|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	gnl|CDD|275223	TIGR04430, OM_asym_MlaD, outer membrane lipid asymmetry maintenance protein MlaD. Members of this protein family are the MlaD (maintenance of Lipid Asymmetry D) protein of an ABC transport system that seems to remove phospholipid from the outer leaflet of the Gram-negative bacterial outer membrane (OM), leaving only lipopolysaccharide in the outer leaflet. The Mla locus has long been associated with toluene tolerance, consistent with the proposed role in retrograde transport of phospholipid and therefore with maintaining the integrity of the OM as a protective barrier.	6.51905e-59

Protein sequences

>NZ_CP042218.1|WP_144891693.1|1578329_1579451_+|VacJ-family-lipoprotein
MDLPTLPHRRILAAALALALLSACASGGTAPIAPAPAPDAQARVVDGSADGATADAAGTGAASARAPVAQDGTAAASDGGEPLPGDDGQGTDDTVIATGETVAIDPTQAELDYAAIYGGEVYDPVADSTLPDPAAPPPPGHDPWEHWNRRVHAFNMAVDRAVAEPLARAYVKVVPRPVRLGVGNFFSNLGQPVSALNALLQGKPGQAGHSLGRFLVNATLGIGGLFDPASRMNIPNRSEDFGQTLGVWGWERSRYVELPLFGPRTVRDVFGLVGDGQVAPLRQIDDDAVRIGLQGLQLVDLRTQLFAVDRLREGAADEYALVRDAWLQRRDYQIRGDRLREDQEDLPDYLLEDEGNPTVPVDVMPIVPGSTPP
>NZ_CP042218.1|WP_144891691.1|1578010_1578307_+|STAS-domain-containing-protein
MPAPETEAGVRRDGEALRFDGALVRDAVPTLWRAARPQAAGVRRIDITAVTGIDSAGLALLSALAATAGPGAEITGAPPGLAELSAAYRLDGALGFSH
>NZ_CP042218.1|WP_144891690.1|1577355_1578030_+|ABC-transporter-substrate-binding-protein
MTIRPLIPFVLASAVLAAAPFAQAQAQAQAAPPAASTMQGESPSKLVLDNSQRILSTLESRRAEFTADRGKLQDFIASEFDQMFDREYSARQVLGRHGRGASDADIKVFADALADSLMRRYGSSLLDFNTRLRVRVKSETPLPRGLGVKVSSEMLRQGGEPIPVDYLMRRAGNGWRVFDVMVEGVSFVQTFRQQFDTPLTRKSIREVAADLSAGRMQADAGAGN
>NZ_CP042218.1|WP_144894023.1|1576825_1577359_+|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD
MTSRGPRLEFAVGAFLLLALASMLVLAVASTNGRFGFAGDTYELTARFTNLGQLRPNAPVKVGGVTIGHVAGIDLDPVKFDTIVTLAIDSRFNEIPIDTSAQILTGGLLGESYVGLLPGGDMEVFQPGEELVYTQPAVDLMQMVGKYMFSGGGEDGAGARAAAPDANDTPPPTEPTP
>NZ_CP042218.1|WP_144891688.1|1576041_1576791_+|MlaE-family-lipid-ABC-transporter-permease-subunit
MPFVSSTRSLGRAGLFSLSVFAASKPTADFFAELLREIYKIGARSLPIIAVGGAFVGLSLTLLGFRALETYGAANQVSVLIGLGLYRELAPVLTALLFIGRAGSSIAAELALMRATDQIQALGLMAIDPVAKAVAPRFWAAVLCVPLLTAFFVSLALSASWLMAVHVLGVENGTFWQTMRDAVDFKDDFLVAFLKSAVFGGTSALVAAYVGFHAEPTIEGTSVATTRAVVNASLLVLMFNFVLSAALFR
>NZ_CP042218.1|WP_144891686.1|1575154_1576042_+|ATP-binding-cassette-domain-containing-protein
MPHTAPDTNVPAVRLSGVRLDRGVRTILSGIDLEVPRGSITAILGPSGSGKSTLLAAITGELAPAAGTVEVFGRPVPRHHRELLELRKGIGVLLQGNGLLTDLTAGENVALPLRTHTKLPAPVIEQLVLMKLHAVGLRTAVDLYPRELSGGMARRVALARALALDPPLMLYDEPLTGLDPIASGVIMSLIARLNATLGLTSIIVSHHVRETLPIVDQVLVTANRGIVFAGTPAELEASEDPLLRQFLRGEPDGPIAFDPASAQPSARDALARAADAAPTRLAATPAAPRIDAEAR
>NZ_CP042218.1|WP_144891684.1|1573759_1574437_-|hypothetical-protein
MKEMPRFDYFALHYLKLWEGGDQALHTDLSSDNPTLEALTKAMHAFRISRSFRGIAEAGNRKYVLESLLGVGKDGAKAVNKLASKFEDRFSKENLSAASKLLWFRHRSPFLVYDRNAVTALSALASRRIPRSYDEFEKVWRSEFKKVEAQVAAACGRLTSLHRYFHHAYGEDELEHLVSSLWFHERVFDVYLWAIGGRFLVDKGARGIGSPGQNDMHVADRNPVS
>NZ_CP042218.1|WP_144891682.1|1570358_1573739_-|exodeoxyribonuclease-V-subunit-gamma
MSPTSAGFRLYHSNALEVLAGILAEVLRAPVSRERLLEPDIVLIPQAAMRRWLQATLAARHGVAANIEFLTPGEFVGRALDANLGPADGELDARTLHWHLYAALTDRALLEQPALAAIAAHVGGDDPLRPWSLAGELASVFEKYQAWRRDWLLRWEGGADPDDPQAILWRRVARGTRHRARRIQDYLERFEAPDAALPAGLPARLSAFATLNVSPDVLRVVATQARVGTLHCFVPSPSQAYWGDLQRMRTVPEAALATEGALLAGGESRLLQAWGAAGVDFMRLVGNYEVVHASAELRAHADPAEGGGPLQGSLLRRMQSDVFHRRGEPGFALRPAVDRTDPSLQLHACHTRLRELQVLRDQMRALFDDDRFDPPLQPREVAVLAPDIDPYLPYLGAVFGDRGADDAIPYALADASPLANEPLAEVFLRLLALPVSRFGLHEILDLLASPALAEANGLDAPAIERLQAWLSEAGARWGLDARHRARFDAPEDEAYTWAFALDRLLLGHASGSDALVRASDGRLVAPLPDLEGGAMDALDTLLRLLRVLERHAELLGEAMPPAQWRERLLELLDALLPRPPASAAGQRALDRLRTLVDAFARNAGDAGFDAPVPAEAVRAHFGAVLAEADVRAPLLTGGVSIARMVPMRLLPFRVICVLGMNDAEFPRRDPAPGLNRLTAELGTGRRRAGDRSTRDDDRFLFLQLFTAAQDVFYVSWQGADPRDGSRREPSVLVSELIDAAAAQHAADAADDIAEALVVRHPLQPFSAEAFGPKDEPRRFSYHARWQQAAAGAADRRVPLPPWFEGAPLAGDDLEPELPIGALRRFLLQPAESLLERMGLRLVEIEAHGDDVEPLAAPERGLERSVLQRALFDELLQGHDEARIHATLRARGLLPSGASGRRVLADQREVLAPWLEAFGAWRGNAQPRSLPAEVEIDGVRVHGRIQDAWPQGIARLRFGKPNGPSVIRSGLDWLLARAAGIDLPFLDFFETDPGAVGPYARAPLSPAEARDALRRLLALRAQGLREPLPYAPYSAWAYASADNADKAVEAARKQWHGAGGGFAEGQGDALRQVLRGCDPFADEPALVRFADAAMTVFLAVRDGQAYEGVDPGTLAGLARAHDPEEVE
>NZ_CP042218.1|WP_144891680.1|1566732_1570362_-|UvrD-helicase-domain-containing-protein
MNAPLDPYATQPLHGVFAIEASAGTGKTFTLATLLARLVLERALGVGRILAVTFTEAATQELRARVRQRLVLAADVASGDDGHASPEAALMRQLIEAHLARGGESHDALRRRLRRAADDIDMAAIFTIHGFCARVLREHALESGQGFDAPELLASDADLRAAIAADLWRAHAVDADAVDDLHALWPQGPDALAKDLSPLVREDVLLPAPPAALPDPGPMLRAAAQAFAEAARTHGDGFRDELLRATESKVLKGQSYKADWIQDLFDQLARWCDRGDHVSRFKHDKLGHLHREKLLDCTSKAGAGRTPESPLCDAVAEYAAALAEADRIREARQAALLHRLRDDARRRLARHKQLARVLTFDDQIDRVATALAGPHGDALVERLRAQYRIALVDEFQDTDPRQWAIFERVFGADSPEPALFLIGDPKQAIYGFRGGDVETYLAARATAAMAPPLASNFRSRPAVLRGIEALYAQAQAVHEGEPDRVAPPFIDARIAFHPVQPGGARDDAEYQRAGQPAPAITLWRAPEPAPDRHGKPKPHSAPRSRELATRACLAAIHRVLGDARAGTATLKGRPVRPGDIAVLVRKHREAVMIRDALAAVGIPAVAAGKQSLFATAEARELHTLLQALVHGADDRRLRAALATVLVGEDAHAIAALDADGEVLQQKQLEALAWGERLRRAGPLALVGELCARHAPRLLGLMDGERRLTNYLQLAEHLQEAQRTALGLHGLLDWLARAIAGASADDEAQQLRLESDARRVQIVTLHKSKGLEYPLVFLPYVGIGGRPPHHGGRVVVHGDDGRVLHWKLQEADSGWKDALAAWERHERAEDARLLYVGLTRARDALWLATGRFYNHEQSPLWTMVSDADALVARAAGTIAIDAATPLDVLPWLGADSTEDVPPARTATRALASDWWVYSFTQLAHADGGHDTASAATQPAAGGRDEPVDATARADAEAETFDPRFGGARFGVVLHDAFEHADFAAWRGWRPGDAAPDGELRKITAALGRGGYAADDIEDGVAVITPMLGHSLTAVLPEGCALVDVPAVQRRPEIEFQFALAPTRVDALLALLHRHGLVTGRQGFGLRRRLEGLMTGLIDLTYLHDGRWYVLDWKSNRLPGYGAADLEQAMAASEYTLQALIYTLALHRWLRFRLGAAYDYARDFGGARYLFCRGIDATAGDDRGIHAWRFAPELVHALDALFAGEPREAAA
>NZ_CP042218.1|WP_144891678.1|1564840_1566736_-|exodeoxyribonuclease-V-subunit-alpha
MSLLQALVRARALRPLDHALAQSLRRLDPDTPDAVLAAAALASLAVAEGHAGFDPAEPQRLMDAPIAWPDIDTWRRALGASRWVACPERGDAESAPDAPLVFEHGLVYLRRYREYERRLADGLRRIGHAPPQHGAAGAAGSAGSAGSAGAGAGAALADSDDAPAPADGDDAHVPASLAPLFARLFPEAATSDDPQSRAAAAALRHRLLLVTGGPGTGKTTTITRVLVLLVAQAIESGHPPPRIALAAPTGRAAERMAESVRHAVQALTALGVDAELCARLPTTGTTLHRLLGTLPDSPRFRHHADNPLPFDVVVVDEASMIDLPLMAKLVEAVHAGARLVLLGDPDQLPSVEAGDVLAGILRAAEARATAASFPARHIHLTRGWRQSAALDLAPLAAAVREGDADTALSLLRGGGLSGVHFHEGNVDPLQTHREQLLAHWASLAEARDPAEALARAGRMRVLTAVREGPQGARGLNARIEEMLAGARRGAGPASAAGRYFHGRLLLVTENSYRHRLFNGDIGICLRDDSGTLMAWFPGDDPGNPRPFHPAALPAHDSAFAMTVHKAQGSEFDEVWLVLPERFNRVWSRELVYTGLTRARRMLNVGAGESVIRGMLSNHASRWSGLGRRLSQ
>NZ_CP042218.1|WP_144891695.1|1579616_1580996_-|DNA-recombination-protein-RmuC
MNVETLLMLVLGAVAVAIALLVALLLRRPERALAEMRRDLEEVLRTEQRDGRGELRLQLDSLGMAQGQRIDGFAARLTEFSARTDQRLDVLREALGEDARKARTEGAEVQQRFAESLGQRLAELTQRNEQRIAEMRITLESQLKALQADNAQKLEQMRETVDEKLQTTLEARLGASFKLVSERLEQVQRGLGEMQELATGVGDLKRVLGNVKTRGIFGEVQLAILLDQVLTIEQYETNCITVPGSNDRVEFAIRLPGAEAGRSIRLPIDAKFPRDDYERLLDAQERAETEAITSAGNALERQVKTDAKRIRDKYLAPPHTTDFALMFLPTEGLYAEVLRRPGLFEALQRDFRVTVVGPTTLLALLNSLQMGFRTLAIEKRSSEVWHLLGAVKSEFGKFATVLEKAHGQLDTVQNSIKQAGVRTRAIERQLRGVETLPGEEARKLLGDVVADAVGDDPAG
>NZ_CP042218.1|WP_144891696.1|1581049_1581403_+|DUF488-family-protein
MKIHARRVYSEPATGEGHRVLVDRLWPRGKSKAELDGIPWVKSIAPSDGLRDWFGHDPDKWPEFKRRYFAELDANPGGVAELRKALGRGSNATLLYAAKDEEHNNAVALAEYLGRHS
>NZ_CP042218.1|WP_144891698.1|1581920_1583087_-|methyltransferase-domain-containing-protein
MNDALPVVRLRNAWRSSHPWIFQKLVEKPNPRPKPGSIVDVVGVDGEWIGRGFYNGHSRIAVRILETDPGVAVDAGWFARRIAEAVSLRREVLRLDAVSDAWRVVHSEGDGLSGLVVDRYADLLVLEYFSAGMFRHREWIMEALRAQFPGCRFHAFADEHVQKQESFDFHGTPGTEPAVITEHGIRFRADPAGAHKTGFFADQRENREWLSRYVDGRRVLDLCCNTGGFAVYSAVRGAAEVVGVDIDGDVIEIAKGNARLNNVRPRFVQADIFPWLRDASNAGELYDVVILDPAKMTRDREQVIPALKKYLDMNKLALSVVKPGGLFATFSCTGLVSEDQFLDMLRRAAFFSNRTVQVLKVSGAGPDHPFMANAQESRYLKAVFCRVV
>NZ_CP042218.1|WP_144891700.1|1583214_1583997_+|rhomboid-family-intramembrane-serine-protease
MHLPDHDHPPDSVAQRAADWRHFRRAVGASLAFVAVLAVVHAAQAGFDARLFSVAPGSAAGLLGLLTAPLLHGSLEHLVANSVAVILLGTLAGWVYPRASLRGLPLMWLGSGLGAWLLGDPGSYHLGASGVTHGLMFLVMTLAVLRRDRAAIAASMIGFMFYGGMLLTVLPREPGVSWQSHLGGAVGGIVAAWVFRRLDPVAPRKRYSWELEEEQAAIAAARAQAEREQFESGAPDDVPVLWHRPEEERGTILEFPRRDR
>NZ_CP042218.1|WP_144891702.1|1584076_1585273_+|serine-hydrolase
MRATATLILLLTALPWGGALGSDAMADIDARLQPYTGDVPGAALLVLRDGEPVVRRTVGLADVGAGVPVTPATNFRLASVSKQFTAAAVLLLAEDGRLRLDDPVRRWLPALPASADGVTLHHLLSHTSGLHDYEDLMAAEFQGQVRDADVLCLLASGQPCALGDATVRDGNGESVAYAADAAAKPPASRAATAAADTGEPYFPPGSAYRYSNSAYALLALVVEQASGRAYPEFLRERIFEPLGMDHTVAFVDGVNAPANRAFGHSARGDGWARTDQSTTSAVLGDGGIYSSIDDLAKWDAALYDERLLSDASRALAFSPQTTTPTGEADVAAYGYGWRLDGEGLMWHSGETIGFRNVILRWPAQRLTVLMLSNRNDPEPYAAARAIGDAFLRETAGTR
>NZ_CP042218.1|WP_144891704.1|1585302_1587000_+|M28-family-peptidase
MLLAAARRLTPAAFVLALLLAMPACKREPAPEAGAPTAAVLERSQDPAAHRIEDDVRALADDRMQGRETGTPGHELAADHVAQRFADAGLVPGGEDGGWFQRVPLLRATLDADARLQIHLDGRVRALEFQRDFLPLANFDLPEASVGEAPAVFVGQAIHAPGLGHDDFAGLDLRGKVAVMFGGAPERFDATRRAFHGSTREKLQNVAARGAVGAVFAGTAADEVRAPWARSAADWQRPSMRLRDADGRAIDGWAGLEVVARVSAAAADALFAGGDRSAAQLADAARAGTAGGFDLPVRLSLAARTRVEPLDSRNVVGLLRGSDPVLADEYVVHTAHLDHIGIGAGVDGDTIHNGALDNALGVAIMTEAARGLAAADAAPRRSQLFVALTAEEQGLLGSQWFATRPTIPRGALVANINIDMPVLTAPSRDVVAIGAEHSSLAAVVAAAASDIGVRVSPDPFPEEAVFVRSDQFSFVRQGVPAVYLDAGIEPVDPDRDPKVSATWFMRNCYHRPCDQADLPIHYDDAARLARLSARIAGLIGDADARPAWNEGDFFGERFSGAAGVR
>NZ_CP042218.1|WP_144891706.1|1587059_1587365_-|hypothetical-protein
MRQWLRTHPFLLLGVGSLFLFLLLLVVDLPSGSLRLRTLVALWKVAGIGPHAVSNLLARYAPGLPGAVDAALVVILGLLPYLGADAVLARARSRRRRPNDA
>NZ_CP042218.1|WP_144891708.1|1587484_1587760_-|DUF4242-domain-containing-protein
MTQYLIEREMAGAGNMSREALRDASRRSNEVLAEMGPGITWVQSYVAGDKIYCIYDASNEQLIREHAEKAGFPADRITPITAVIDPGTAEG
>NZ_CP042218.1|WP_144891710.1|1587756_1588152_-|hypothetical-protein
MMQIVLPLLLVPAIASAAPKQPDAGSDDCYNRATQTCNREHPGKDLGDAGYRQCINDTLDWCDANEPASHAGGLLPALDLHGRFVDARGSSVESLPVKGGKRYELRCIEVDVASDNPLKASRANPATGEKR
>NZ_CP042218.1|WP_144891712.1|1588283_1588574_-|mitomycin-resistance-protein
MNPSRVVREEVKRFTDLPNVGPAAARDFEVLGYSEPGQLVGADPLDLYQSLCIATGTRQDPCVLDVFMSVTSFLAGGPPEPWWHFTEKRKQRYGRL

Crispr_ID: NZ_CP042218_4

• CRISPR_ID: NZ_CP042218_4
• CRISPR_location: 2033758-2033849
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP042218_4

Consensus_repeat	Method
GAGGGCGAGGAGGCGCTGGCCGA	CRISPRCasFinder

spacers of NZ_CP042218_4

>4.1|2033781|46|NZ_CP042218|CRISPRCasFinder
CCTCGCGCGGCTGGCACGCGCCACCGCGCAGGACGACGGCGACGAG

CRISPR arrays and Neighbor proteins around NZ_CP042218_4

CRISPR arrays

The CRISPR arrays of NZ_CP042218_4

>merge|NZ_CP042218|4|2033758-2033849|CRISPRCasFinder
GAGGGCGAGGAGGCGCTGGCCGACCTCGCGCGGCTGGCACGCGCCACCGCGCAGGACGACGGCGACGAGGAGGACGAGGAGGCGCTGGCCGA

>NZ_CP042218|4|4|2033758-2033849|CRISPRCasFinder
GAGGGCGAGGAGGCGCTGGCCGA	CCTCGCGCGGCTGGCACGCGCCACCGCGCAGGACGACGGCGACGAG
GAGGACGAGGAGGCGCTGGCCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042218.1|WP_144892398.1|2028480_2029128_-|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl|CDD|234816
NZ_CP042218.1|WP_144892400.1|2029124_2029610_-|EVE-domain-containing-protein	unknown	unknown	gnl|CDD|225498
NZ_CP042218.1|WP_168198978.1|2031053_2033186_-|EAL-domain-containing-protein	unknown	unknown	gnl|CDD|236645
NZ_CP042218.1|WP_144894092.1|2020933_2021575_-|thiamine-phosphate-synthase	unknown	unknown	gnl|CDD|234590
NZ_CP042218.1|WP_144892412.1|2035266_2036607_-|Xaa-Pro-dipeptidase	unknown	unknown	gnl|CDD|237444
NZ_CP042218.1|WP_144892392.1|2019639_2020932_-|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl|CDD|234607
NZ_CP042218.1|WP_144892418.1|2040648_2041248_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl|CDD|234648
NZ_CP042218.1|WP_144892404.1|2030509_2030803_-|cell-division-protein-ZapA	unknown	unknown	gnl|CDD|377476
NZ_CP042218.1|WP_144892414.1|2036671_2037022_-|PilZ-domain-containing-protein	unknown	unknown	gnl|CDD|377796
NZ_CP042218.1|WP_144892420.1|2041251_2041983_-|ribonuclease-PH	unknown	unknown	gnl|CDD|178914
NZ_CP042218.1|WP_144892396.1|2021864_2022317_-|DUF192-domain-containing-protein	unknown	unknown	gnl|CDD|376876
NZ_CP042218.1|WP_144892394.1|2021629_2021857_+|rubredoxin	unknown	unknown	gnl|CDD|224687
NZ_CP042218.1|WP_144892422.1|2042047_2042908_+|YicC-family-protein	unknown	unknown	gnl|CDD|236993
NZ_CP042218.1|WP_168198979.1|2037018_2039376_-|DUF1631-domain-containing-protein	unknown	unknown	gnl|CDD|377917
NZ_CP042218.1|WP_144892428.1|2044092_2046249_+|RelA/SpoT-family-protein	unknown	unknown	gnl|CDD|223394
NZ_CP042218.1|WP_144892402.1|2029606_2030188_-|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl|CDD|274270
NZ_CP042218.1|WP_144892424.1|2042900_2043566_+|guanylate-kinase	unknown	unknown	gnl|CDD|234719
NZ_CP042218.1|WP_144892406.1|2030799_2031021_-|TIGR02449-family-protein	unknown	unknown	gnl|CDD|131502
NZ_CP042218.1|WP_144894095.1|2033993_2035259_+|M24-family-metallopeptidase	unknown	unknown	gnl|CDD|182804
NZ_CP042218.1|WP_144892426.1|2043659_2043959_+|DNA-directed-RNA-polymerase-subunit-omega	unknown	unknown	gnl|CDD|234744

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP042218.1|WP_144892398.1|2028480_2029128_-|ribose-5-phosphate-isomerase-RpiA	gnl|CDD|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	4.77111e-120
NZ_CP042218.1|WP_144892400.1|2029124_2029610_-|EVE-domain-containing-protein	gnl|CDD|225498	COG2947, COG2947, Uncharacterized conserved protein [Function unknown].	8.44926e-76
NZ_CP042218.1|WP_168198978.1|2031053_2033186_-|EAL-domain-containing-protein	gnl|CDD|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	1.34637e-111
NZ_CP042218.1|WP_144894092.1|2020933_2021575_-|thiamine-phosphate-synthase	gnl|CDD|234590	PRK00043, thiE, thiamine phosphate synthase.	3.0776e-72
NZ_CP042218.1|WP_144892412.1|2035266_2036607_-|Xaa-Pro-dipeptidase	gnl|CDD|237444	PRK13607, PRK13607, proline dipeptidase; Provisional.	0
NZ_CP042218.1|WP_144892392.1|2019639_2020932_-|glutamate-1-semialdehyde-2,1-aminomutase	gnl|CDD|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NZ_CP042218.1|WP_144892418.1|2040648_2041248_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl|CDD|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	1.89589e-111
NZ_CP042218.1|WP_144892404.1|2030509_2030803_-|cell-division-protein-ZapA	gnl|CDD|377476	pfam05164, ZapA, Cell division protein ZapA. ZapA is a cell division protein which interacts with FtsZ. FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission related proteins early in the bacterial cell cycle. The interaction of FtsZ with ZapA drives its polymerization and promotes FtsZ filament bundling thereby contributing to the spatio-temporal tuning of the Z-ring.	2.99892e-17
NZ_CP042218.1|WP_144892414.1|2036671_2037022_-|PilZ-domain-containing-protein	gnl|CDD|377796	pfam07238, PilZ, PilZ domain. PilZ is a c-di-GMP binding domain which is found C terminal to pfam07317. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain forms a beta barrel structure.	6.7858e-07
NZ_CP042218.1|WP_144892420.1|2041251_2041983_-|ribonuclease-PH	gnl|CDD|178914	PRK00173, rph, ribonuclease PH; Reviewed.	2.22311e-173
NZ_CP042218.1|WP_144892396.1|2021864_2022317_-|DUF192-domain-containing-protein	gnl|CDD|376876	pfam02643, DUF192, Uncharacterized ACR, COG1430. Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for Structure 3pjy shows that there is much similarity with the other solved structure, Structure 3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. Structure 3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).	4.04726e-50
NZ_CP042218.1|WP_144892394.1|2021629_2021857_+|rubredoxin	gnl|CDD|224687	COG1773, COG1773, Rubredoxin [Energy production and conversion].	8.78451e-23
NZ_CP042218.1|WP_144892422.1|2042047_2042908_+|YicC-family-protein	gnl|CDD|236993	PRK11820, PRK11820, YicC family protein.	4.30616e-124
NZ_CP042218.1|WP_168198979.1|2037018_2039376_-|DUF1631-domain-containing-protein	gnl|CDD|377917	pfam07793, DUF1631, Protein of unknown function (DUF1631). The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned is approximately 440 amino acid residues in length.	3.76517e-131
NZ_CP042218.1|WP_144892428.1|2044092_2046249_+|RelA/SpoT-family-protein	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
NZ_CP042218.1|WP_144892402.1|2029606_2030188_-|5-formyltetrahydrofolate-cyclo-ligase	gnl|CDD|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	2.54436e-48
NZ_CP042218.1|WP_144892424.1|2042900_2043566_+|guanylate-kinase	gnl|CDD|234719	PRK00300, gmk, guanylate kinase; Provisional.	1.36849e-117
NZ_CP042218.1|WP_144892406.1|2030799_2031021_-|TIGR02449-family-protein	gnl|CDD|131502	TIGR02449, conserved_hypothetical_protein, TIGR02449 family protein. Members of this family are small proteins, typically 73 amino acids in length, with single copies in each of several Proteobacteria, including Xylella fastidiosa, Pseudomonas aeruginosa, and Xanthomonas campestris. The function is unknown.	4.72939e-11
NZ_CP042218.1|WP_144894095.1|2033993_2035259_+|M24-family-metallopeptidase	gnl|CDD|182804	PRK10879, PRK10879, proline aminopeptidase P II; Provisional.	2.48636e-144
NZ_CP042218.1|WP_144892426.1|2043659_2043959_+|DNA-directed-RNA-polymerase-subunit-omega	gnl|CDD|234744	PRK00392, rpoZ, DNA-directed RNA polymerase subunit omega; Reviewed.	1.50018e-21

Protein sequences

>NZ_CP042218.1|WP_168198978.1|2031053_2033186_-|EAL-domain-containing-protein
MRRVVVWLHECERSFRLALWAGGQRHWDFHIPDRRLRYLVARRDDGGQGPHFGSGEADPAAVIHPDDLPAVADAMQRYVAGDASEFLSEYRVRVDGRATGRNNWVWVRARGRAVEHGPDGSILRVAGTSLDIDRSRAVERENRIASEVLRSMNEAVAVLDARFNFLSVNPAFSRITGYAAAEVVGRDARMLDSPRHQPSPGVAMRAALAREGHWSGETWQCKDDGEEFLCAVEAVTVPAPDDGGEPMHVLVLNDITQHKRAEEELRYLASFDALTNLPNRSLLAERLSRAVVRARRAGARVAVLFVDLDRFKDINDSLGHAMGDRILRAVAERLQQTVGPGQTVARLSGDEFTVVLENVADPADAERVAREIIMAFEVPVAPGDGREVSVSASIGISLYPDHAQVPTELLKRADAAMYQAKAAGRRTWMRYDDSMEAAIRRRAVLSGALHKAIDRGELRVVYQPRQALATSRITGAEALLRWTSPEHGEIPPAEFIPLAEENGMIFEIGEWVLREACLAARHWRDHGLLDVAVSVNMSALQLLRGDFAEVVRRMLDDTGLPPHALELELTESMLMANADQAAHRLRAFRELGVALAIDDFGTGYSSLAYLKRLPITTIKIDQSFIADLGHAPEGASITTTVIAMAHGLGLGVVAEGVESEAQARYLTRCHCDEIQGFWVSEPMDAASCMAFIHARPPSAAAVALPAPAAS
>NZ_CP042218.1|WP_144892406.1|2030799_2031021_-|TIGR02449-family-protein
MDTPDVLAQLQRLSERFEELAVHTRRLAEENRSLRQQHEQVSGERAQLLAKNEQARSRVEAMIARLKSLEQHT
>NZ_CP042218.1|WP_144892404.1|2030509_2030803_-|cell-division-protein-ZapA
MSSTEAVSVRVLDREYTVGVGSGEVDGLMAAARVLDARMREVRGANRMAAIDRVAVLAALNLAHELEQLRREGEQREREVARALSALQARLDTLLDA
>NZ_CP042218.1|WP_144892402.1|2029606_2030188_-|5-formyltetrahydrofolate-cyclo-ligase
MTVARADQRRVMRERRREVPPAARIGAADGLAAQLLALPLAPGAKVAGYWAADGEIPLHTWQLRLPPRCTYCLPVLHEGGYLRFAPWRPGEPVAPNRFGIPEPVAAPDALLDPSSLDLVVVPLVGFDARCHRLGMGGGWYDRSFAFRHHRPAPPLLVGAGFAFQQVEGELRSEDWDVQLDAVCTERGTLFRPT
>NZ_CP042218.1|WP_144892400.1|2029124_2029610_-|EVE-domain-containing-protein
MSTTGMRRRYWLMKSEPEDFSIDDLERVGTEPWTGVRNYQARNFMRDGMRRGDGVLFYHSNCAVPGIYGIAEVASSAYPDPTQFDRTSKYFDPKATREEPRWMLVDVGFVRSFAAPVTLEAIRGRAEALGEDFALIRKGSRLSVLPVNAAQWKILLAMEPK
>NZ_CP042218.1|WP_144892398.1|2028480_2029128_-|ribose-5-phosphate-isomerase-RpiA
MSDAKRLAGEKAIEHVEDGMVVGVGTGSTVAFFIDALAELRDRIAGAVSSSDQSTARLRGHGIEVLDLNACGPIPLYVDGADECDPGKRLIKGGGAALTREKIIAEAAEKFICIIDPSKEVPVLGRFPLPVEVIPMARSLVAREILAMTGGQPVWRQGTVTDNGNWILDIHGLAITDPVAMERALNQIPGVVSVGLFARRPADVVIVGGNPPLVR
>NZ_CP042218.1|WP_144892396.1|2021864_2022317_-|DUF192-domain-containing-protein
MRNFLSMFVLWWACVSATACASDGRWVELAGQRYAVEVAETDEARARGLMFRDSLAEGHGMLFIHEREERQAYWMKNTRIPLDILYFDSELRLVSQQRNVPPCSAGDRCPPYPSSGPARYVLELNAGEARRLGLEEGTVLALGPAIDPAR
>NZ_CP042218.1|WP_144892394.1|2021629_2021857_+|rubredoxin
MAARVHDAAAAHYPMSQTATAYRTWMCVVCGFIYDEARGLPAEGLAPGTRWEDVPDTWTCPDCGVTKDDFEMVAV
>NZ_CP042218.1|WP_144894092.1|2020933_2021575_-|thiamine-phosphate-synthase
MHPARSVGRGLYLLTPDETDTGRLLARVEAVVGHAALLQYRNKAAQGALAREQVSALLPLCRERGVPLLVNDDWRLALACGADGAHLGEDDGDLRAARDALGADAILGASCYDSLPRARAAAASGADYLAFGAFFPSSTKPLARRATPELLREARQFGLPLVAIGGITPDNAGMVVEAGADLVAVISGVFDAPDPVAAAQAYHRTFRKTQEAN
>NZ_CP042218.1|WP_144892392.1|2019639_2020932_-|glutamate-1-semialdehyde-2,1-aminomutase
MKHEKSRALFARAQALIPGGVNSPVRAFRSVGGEPFFVERADGAFLYDVDGNRYIDYVGSWGPMIVGHNHPGVRAAVAEAIGSGLSYGAPCPAEVTMAETITRLVPSCEMVRMVNSGTEATLSAVRLARGATGRQRIVKFEGCYHGHGDSFLVKAGSGMLTLGVPTSPGVPAGLSELTTTISYNDFEEATALFDDIGGEIAAVIIEPVVGNANCLPPREGYLGHLRELCTKHGALLIFDEVMTGFRVALGGAQARYGVTPDLTTFGKIIGGGMPVGAYGGRRDLMERIAPAGPIYQAGTLSGNPVAMAAGLAMLGLIQEPGFHDRLEATANVLCDGFEQAAREAGVPLTTNRVGAMFGLFFTDRKVDTYAGATACDTGAFNRFFHAMLDRGVFLAPSAYEAGFVSSAHDADMVEATLSAARDAFRVVAAG
>NZ_CP042218.1|WP_144894095.1|2033993_2035259_+|M24-family-metallopeptidase
MRMAGDDAILVLPAAPERVRSRDTFHPYRQDSDVLYLCGFEEPDAVLVLVPGRSHGESLLFCRERDPEREAWDGARIGPDGAPDALGVDDAYDIEDLDDILPGLLEGRRRVYYHFGRDTGFDLKLIGWLNRVRAEVRHGAQPPHEFLELGHLLDEMRLIKGADELKLMRRAAKISVQAHQAAMRAVRAGMHEYELQAELERVFRAAGCVPAYGSIVGAGANACVLHYRANDAQARRGDLVLIDAGAEHRGYAADITRTFPVDGRFSREQRALHDLVGAAHAAALAEARPGVPWEAGHNAAVEVLTEGMLSLGLLKGRLRKALADQAYKRFYPHKTGHWLGLDVHDVGDYRIDGESRLLEPGMVYTIEPGIYIPPGDTGVAEKWRGIGIRTEDDVVITRDGHEVLTAGLARSADEIEAFMAG
>NZ_CP042218.1|WP_144892412.1|2035266_2036607_-|Xaa-Pro-dipeptidase
MIAESLAALYPAHLETLIARATVALERGGFDHLLVPSGTLHYQVFDDRDYPYAANPQFKHWVPLVRNPGSWLAFTPGERPKLVYLQPRDYWHVVPEAPSGYWAEHFDIAVIRKPDDALQHLPRNATRCAILGEPQSALGRYGAFAPNNPQPVLDYLEYHRAYKTPYEIAMMREATRRAVRGHRAAERLFRAGASEFGIHLAYCQAVGQDANELPYGNIVALDAHGAVLHYTELDRVPPKSVRSFLLDAGASHGGYAADITRTHAMDRGSEFQAFIDAVERAELELCGKVRAGMDYRQLHLDAHIALARVLEDFGFITCGAEEAVATGLSSSFFPHGIGHGLGLQVHDVAGFAASDAGGTIDKPQGHPYLRLTRELAPGMVVTIEPGLYFADMLLEDLKAGSNAGRVDWNRVEAFRSYGGVRIEDNVVCTDGEPVNLTREEFAAGSA
>NZ_CP042218.1|WP_144892414.1|2036671_2037022_-|PilZ-domain-containing-protein
MMDEFRRARRRKAPGTILVMDAMSERVVGRIGNLSMSGMLLMASVPLAEDSLYQFRFSLPLEGGSESTIEIGVHLLWMDRASAPGQAWAGLRFIGMTEAQAGPLRAWIDAPGSRYE
>NZ_CP042218.1|WP_168198979.1|2037018_2039376_-|DUF1631-domain-containing-protein
MTYIHDGAARRTLATVDLPRRVRKVLDAALNLASVELDPFLHALLDEYEQELFRLAEQARHPGSESTYVQALRSFRVCRPDLIPQLMLELECELALLRSPSADGGTPAAAGAPAGERVLGLIDDSQLDEDTLLGEIATRQESRASLSMHLLGQRFGVLAGTPALDAARLPLGPQCMCRALRNACRSLQVPDETRELLYRLFDRVVMTHYAPFLERLDAMLDQAGILRGLTHVPVRLRASSLREAEEAAANAAPGAVSGRRARGTGDDVRDIRDDRSDGSRGARRKPRGARITPDQPHTAWMAETTTALTGGDGEASYETLQELLAERRELIGKLRAGRAGSAETTLDTGELMDALGKIQRQPPGLGASRPSLMDVRQMLLAQARQRHGRGATLAQRDNDTFELLHLLYGRLESEMRADAPAAALIQRLQLPLLRAALQDQTFFVEPAHPARALLNTVAEAAASWLDKDDLDPQLLFPLQQAVSEVVDRYDGDSAVFEASNGRLQTHLQAQVRKAEMLERRHIEAARGKDRLEVAKLRSAATLEELLGDHRIPKFSRALLNQAWADVLTLTLLRQGEDSPEWQALLDATRRIVAACARGEQAGDPALAAYIETSLSQVGYHADEAAIIAARLTGSDGGDDGDPASRTELAMKLKARTRLGEDAERARRPALPPRSPEEQARYEQLRVLPFGTWIEFTTNQQGDVVRRRMSWFSPVTDNALFVNQRGQRIGEHSLDSLARMIVAGQARVVTAERGRLVDRAWQSAVRTLRSFAGRAEAPAIGGGAHA
>NZ_CP042218.1|WP_144892418.1|2040648_2041248_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MDLVLASGNAGKLAELRQLLGDRGLSLRAQSEFGVGDVEETGLTFIENALLKARNAARATGLPALGDDSGLCVDALGGAPGLYSARYAGPGGDAARNIERLLRELDGVPDEARGASFHCCIVLLRHATDPRPLVVEGRWHGRVLHAPRGAGGFGYDPVFLDPASGLTAAELPAARKNAISHRGLALATLRERLHELAEA
>NZ_CP042218.1|WP_144892420.1|2041251_2041983_-|ribonuclease-PH
MSQTPRPSGRAPAQMREVRFERGYTRHAEGSVLVSFGDTRVLCTASVENRVPGFLRGKGSGWVTAEYGMLPRATNTRNDREAARGKQGGRTLEIQRLIGRSLRACVDRDALGERTITLDCDVLQADGGTRTAAITGAYVALVDAVRWLRKRREIAGDPIHGAVAAVSVGVHGGVPVLDLDYAEDSACDTDMNVVMNDGGGFIELQGTAEGHAFRRDELDAMLELAAHGCGELFAAQQAALAAG
>NZ_CP042218.1|WP_144892422.1|2042047_2042908_+|YicC-family-protein
MIRSMTAYASGERATPWGTLACELRAVNHRFLEIGLRAPDELRVLEPQLRERISTRVSRGKLDLTLRLRAAEGAATLHVDEALLRRLSAIALDAAPHFPGLRTQFTDLLQFPGVLRSAAPEPEALQAEVQVLLDQVLDGFIAAREREGAKLVAAMLERVDGIEARAAEVRGLVPVIRAGQRAKLEARLADLVQAADPGRVEQELVLSLQKLDVDEELDRLDSHVAEIRRVLGQREPAGRRLDFLLQEFNREANTLGSKSVDARTTNIAVELKVLIDQIREQVQNIE
>NZ_CP042218.1|WP_144892424.1|2042900_2043566_+|guanylate-kinase
MNSADIPTRGTLFIVAAPSGAGKSSIVNACLARDPGISLSISFTSRPPRPGERQGEHYHFVDDARFQRMIDAGDFFEYARVHGDWKGTARQSVEPQLAAGRDVLLEIDWQGARQVRAAVPDAVGVFILPPSRAALDERMRKRGQDSEEVMARRLAAAREEMSHYGEFDYVIVNEDFATAVDEMCAVFTASRLRREAQAIRHAGLIAALLDGSADAGQAASR
>NZ_CP042218.1|WP_144892426.1|2043659_2043959_+|DNA-directed-RNA-polymerase-subunit-omega
MARITVEDCLEVIDNRFELVMMAAKRARQLANGVEPQLDNSENDDKPTVLALREIAARRIDADYVEAVEKSERERREREAMEWAAAEVVADDDLSKGDD
>NZ_CP042218.1|WP_144892428.1|2044092_2046249_+|RelA/SpoT-family-protein
MNSAELALLQVAVPGDEDVPGYMRELERIAAYLPADQLQQLRRAWAVGAAAHAGQTRRSGEPYITHPVAVAAVLAEQKVDLETLVASILHDTIEDTPLTRDALASEFGETVAELVEGVTKLDKLQFGSRHEADAESFRKMMLAMARDLRVILIKLADRLHNMRTLGAQTAEARARIARETLEIYAPIAQRLGMNLIKAELQDLGFRALHPMRHRILEKHIRTQPLVRREAMAKIEAQLAQRLTKEGLSYRLVSRVKSPWSIYNKMRAEAKTFAQVIDVFGFRIVVGTVAECYHALGVAHSVYKPVDGRFRDFIAIPKANGYQSLHTVLFGPYGSPIEVQIRTAEMDLIAERGIAAHWAYKHGGGGPNSAQQRAHSWISGLLEAQSGTGSSLEFLENVKVDLFPDEVYLFTPKGEIMSLPRNATAVDFAYAVHTDVGNRTVAARVDRRLVPLRTRLSSGQTVEIVTAKSSQPRPQWLEFVVTGKARTAIRQQLKQLEHEDAVQLGHRMLDSALEDLDSSLERLPAAELEAYLAEHRYPRLEALLSDVALGTRMPAQVAQSLTNKDPARARTHREDRILITGAERGVVTFANCCMPIPRDEIMGYHTAGRGVVVHRIECPNVAEYRKSPERWVDIGWDREVTGDYHVALRFQVENRPGVLAQVAAAVAQADSNIDAVEYLERDTNAAVIQFAIEVRDRTHLADVIRRVRRLGVVHGVQRL

Crispr_ID: NZ_CP042218_5

• CRISPR_ID: NZ_CP042218_5
• CRISPR_location: 2733532-2733642
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP042218_5

Consensus_repeat	Method
CAGGAGCGGCTCCGTTGTGGCCCGCGC	CRISPRCasFinder

spacers of NZ_CP042218_5

>5.1|2733559|57|NZ_CP042218|CRISPRCasFinder
AGCCCGTCCCCCGCACAGGAGCGGCTCCGTTGTGGCCCGCGCAGCCCGTCCCCCGCA

CRISPR arrays and Neighbor proteins around NZ_CP042218_5

CRISPR arrays

The CRISPR arrays of NZ_CP042218_5

>merge|NZ_CP042218|5|2733532-2733642|CRISPRCasFinder
CAGGAGCGGCTCCGTTGTGGCCCGCGCAGCCCGTCCCCCGCACAGGAGCGGCTCCGTTGTGGCCCGCGCAGCCCGTCCCCCGCACAGGAGCGGCTCCGTTGTGGTCCGCGC

>NZ_CP042218|5|5|2733532-2733642|CRISPRCasFinder
CAGGAGCGGCTCCGTTGTGGCCCGCGC	AGCCCGTCCCCCGCACAGGAGCGGCTCCGTTGTGGCCCGCGCAGCCCGTCCCCCGCA
CAGGAGCGGCTCCGTTGTGGTCCGCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042218.1|WP_144893518.1|2730237_2730870_+|hypothetical-protein	unknown	unknown	gnl|CDD|226789
NZ_CP042218.1|WP_144894183.1|2739997_2740987_+|D-glycerate-dehydrogenase	unknown	unknown	gnl|CDD|240626
NZ_CP042218.1|WP_144893512.1|2725903_2729014_-|diguanylate-cyclase	unknown	unknown	gnl|CDD|143635
NZ_CP042218.1|WP_144893526.1|2736269_2737115_-|phosphatidylserine-decarboxylase	unknown	unknown	gnl|CDD|234591
NZ_CP042218.1|WP_144893528.1|2737111_2737756_-|SCO-family-protein	unknown	unknown	gnl|CDD|239266
NZ_CP042218.1|WP_144893534.1|2742886_2744779_+|hypothetical-protein	unknown	unknown	gnl|CDD|225711
NZ_CP042218.1|WP_144893524.1|2732041_2733223_-|aminoacetone-oxidase-family-FAD-binding-enzyme	unknown	unknown	gnl|CDD|367519
NZ_CP042218.1|WP_144893538.1|2746348_2747563_+|tryptophan-synthase-subunit-beta	unknown	unknown	gnl|CDD|235288
NZ_CP042218.1|WP_144893506.1|2722762_2724070_+|TIGR03862-family-flavoprotein	unknown	unknown	gnl|CDD|274820
NZ_CP042218.1|WP_144893532.1|2741785_2742802_+|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|237845
NZ_CP042218.1|WP_144893508.1|2724066_2724300_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144893516.1|2729470_2730250_+|transferase	unknown	unknown	gnl|CDD|179854
NZ_CP042218.1|WP_144893520.1|2730935_2731313_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144894184.1|2744830_2745664_+|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl|CDD|234577
NZ_CP042218.1|WP_168199009.1|2734138_2734315_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144893536.1|2745665_2746352_+|phosphoribosylanthranilate-isomerase	unknown	unknown	gnl|CDD|234923
NZ_CP042218.1|WP_144893522.1|2731411_2732032_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP042218.1|WP_144893514.1|2729124_2729391_+|DksA/TraR-family-C4-type-zinc-finger-protein	unknown	unknown	gnl|CDD|182903
NZ_CP042218.1|WP_144893530.1|2738895_2740005_+|chorismate-synthase	unknown	unknown	gnl|CDD|235438
NZ_CP042218.1|WP_144893510.1|2724501_2725857_-|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|366370

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP042218.1|WP_144893518.1|2730237_2730870_+|hypothetical-protein	gnl|CDD|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	9.32721e-26
NZ_CP042218.1|WP_144893528.1|2737111_2737756_-|SCO-family-protein	gnl|CDD|239266	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c oxidase (COX). They contain a metal binding motif, typically CXXXC, which is located in a flexible loop. COX, the terminal enzyme in the respiratory chain, is imbedded in the inner mitochondrial membrane of all eukaryotes and in the plasma membrane of some prokaryotes. It is composed of two subunits, COX I and COX II. It has been proposed that Sco1 specifically delivers copper to the CuA site, a dinuclear copper center, of the COX II subunit. Mutations in human Sco1 and Sco2 cause fatal infantile hepatoencephalomyopathy and cardioencephalomyopathy, respectively. Both disorders are associated with severe COX deficiency in affected tissues. More recently, it has been argued that the redox sensitivity of the copper binding properties of Sco1 implies that it participates in signaling events rather than functioning as a chaperone that transfers copper to COX II.	2.2122e-46
NZ_CP042218.1|WP_144893512.1|2725903_2729014_-|diguanylate-cyclase	gnl|CDD|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	1.74264e-46
NZ_CP042218.1|WP_144893526.1|2736269_2737115_-|phosphatidylserine-decarboxylase	gnl|CDD|234591	PRK00044, psd, phosphatidylserine decarboxylase; Reviewed.	1.37068e-159
NZ_CP042218.1|WP_144893530.1|2738895_2740005_+|chorismate-synthase	gnl|CDD|235438	PRK05382, PRK05382, chorismate synthase; Validated.	0
NZ_CP042218.1|WP_144893538.1|2746348_2747563_+|tryptophan-synthase-subunit-beta	gnl|CDD|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_CP042218.1|WP_144893506.1|2722762_2724070_+|TIGR03862-family-flavoprotein	gnl|CDD|274820	TIGR03862, flavo_PP4765, uncharacterized flavoprotein, PP_4765 family. This model describes a sharply distinctive clade of proteins within the larger family of flavoproteins described by pfam03486 and TIGRFAMs model TIGR00275. The function is unknown.	8.82456e-172
NZ_CP042218.1|WP_144893532.1|2741785_2742802_+|aspartate-semialdehyde-dehydrogenase	gnl|CDD|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
NZ_CP042218.1|WP_144893524.1|2732041_2733223_-|aminoacetone-oxidase-family-FAD-binding-enzyme	gnl|CDD|367519	pfam03486, HI0933_like, HI0933-like protein.	0
NZ_CP042218.1|WP_144893534.1|2742886_2744779_+|hypothetical-protein	gnl|CDD|225711	COG3170, FimV, Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion].	3.55067e-31
NZ_CP042218.1|WP_144894184.1|2744830_2745664_+|tRNA-pseudouridine(38-40)-synthase-TruA	gnl|CDD|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	6.0527e-125
NZ_CP042218.1|WP_144893516.1|2729470_2730250_+|transferase	gnl|CDD|179854	PRK04457, PRK04457, polyamine aminopropyltransferase.	1.84909e-48
NZ_CP042218.1|WP_144893536.1|2745665_2746352_+|phosphoribosylanthranilate-isomerase	gnl|CDD|234923	PRK01222, PRK01222, phosphoribosylanthranilate isomerase.	3.00486e-82
NZ_CP042218.1|WP_144894183.1|2739997_2740987_+|D-glycerate-dehydrogenase	gnl|CDD|240626	cd05301, GDH, D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH). D-glycerate dehydrogenase (GDH, also known as hydroxypyruvate reductase, HPR) catalyzes the reversible reaction of (R)-glycerate + NAD+ to hydroxypyruvate + NADH + H+. In humans, HPR deficiency causes primary hyperoxaluria type 2, characterized by over-excretion of L-glycerate and oxalate in the urine, possibly due to an imbalance in competition with L-lactate dehydrogenase, another formate dehydrogenase (FDH)-like enzyme. GDH, like FDH and other members of the D-specific hydroxyacid dehydrogenase family that also includes L-alanine dehydrogenase and S-adenosylhomocysteine hydrolase, typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form, despite often low sequence identity. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	4.31623e-145
NZ_CP042218.1|WP_144893514.1|2729124_2729391_+|DksA/TraR-family-C4-type-zinc-finger-protein	gnl|CDD|182903	PRK11019, PRK11019, DksA/TraR family C4-type zinc finger protein.	4.67359e-52
NZ_CP042218.1|WP_144893510.1|2724501_2725857_-|mechanosensitive-ion-channel	gnl|CDD|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	4.6519e-34

Protein sequences

>NZ_CP042218.1|WP_144893524.1|2732041_2733223_-|aminoacetone-oxidase-family-FAD-binding-enzyme
MTISCDVLVIGAGAAGLMCAMTAGRRGRSVRVIERANRPGKKILMSGGGRCNFTNTGTTPANFISANPHFCKSALARYTPADFIDMVDRHGIAWHEKELGQLFCDDSSKQIVRMLLDECADAGVAVDVDCDVSAVAREGEGFQVDTAHGRVVAHSLVVASGGLSIPSLGGSGLGYALARQFGHTVLPTRAGLVPLVLTGSHAERLEGLSGVSLEVEACSRGQSFRNAMLVTHRGLSGPAILQVSSYWDAGEPLAIDLLPGIDALAFLREQRAARPASELRTVLAECMPRRFAQRLCEHWLGDRPLRQFDEPALAHAAAALHAWPVVASGTEGYRTAEVTLGGVDTGGLSSSTMMSRLVPGLYFIGEVVDVTGWLGGYNFQWAWASGHAAGGVA
>NZ_CP042218.1|WP_144893522.1|2731411_2732032_+|hypothetical-protein
MDLPIRRFAPACLAIACLALGSCVRDDRAVAPGADQPPATSAPPPTPRASLEPDPANAPIERAAPPTLQAVALGRFEPVDPVAGAMTGALEIGDSRIACDSGIVFVTERVAIVRGGDEFSAGQRYADVMMVDALQPVELRRVLDETRADDGRGLCGSMKTGFLALSSQVEQDGRVVKLVALQGDGIPAATAEDTALCAAVTYVSED
>NZ_CP042218.1|WP_144893520.1|2730935_2731313_+|hypothetical-protein
MAKLLLNMRMVPDDEADDVRGFLDANGIGWHETRPSRWGISHGGIWISEDGDYPRARALMDDYQAGRQARARAERAAALRDGSAETFADMLRREPVRVVGLLLGIALGLALVALPVLLLWRAGGG
>NZ_CP042218.1|WP_144893518.1|2730237_2730870_+|hypothetical-protein
MRELIPLPPDMLAGLREAHATPPRAYHHFGHVQAVLAHYGAVAAGPGWARPREVWLAVLYHDAVYKAGRRDNEARSAALAAADIARWLSGAGLDTGFVVELIELTARHGALAPGDLGPGAEGDDRRHFLDCDMAILGADAATFDAYDRAIAEEYRSVVPAWLFRIRRRRFLRGLLHSERIYLSAFFHERLDAPARANLRRVLGDPPTAAA
>NZ_CP042218.1|WP_144893516.1|2729470_2730250_+|transferase
MRGTGPLDPDGKRLPPARLHRHGEYVSLQFRRGQTQSRMRGDAPERLLIDYTRTMLAALLWQPRPAHIGIVGLGGGSQVKFLHRHVPGTRLEVVENHPGVIELRREFGIPDDDGRLQVVFDDGARFVAARPGRYDLLLIDGYDAGGIPEALSTPAFHTACREALAPGGVMATNLHGDDPSHHVERLRATFGRDRVLVLAEPKMSNRVAFAWIGATPAGDAATVEAARAALGEQGRRELAPALERVAGALRQRRKAECAN
>NZ_CP042218.1|WP_144893514.1|2729124_2729391_+|DksA/TraR-family-C4-type-zinc-finger-protein
MATGWAGDGAVQDQIDATVKDAIQRARSRLGSGPGREDCEECGEPIPEGRRKAVPGVRLCLACQSARDAEEAAASGYNRRGSKDSQLR
>NZ_CP042218.1|WP_144893512.1|2725903_2729014_-|diguanylate-cyclase
MICTQTNEATVRRPSAVALALLALAACSGAQAADPGLLRLESHGPDEGLPQSTVRALANDDQGFLWVATQDGLARFDGHRFQVWRAGDDAQDLASGSIDSMAFDPATRRLWLGTNDSGLEVVHLPTWDQVRLDARSGLAHNQIEGIALDGDDGAWIGTRGGLDHVVAETGAVTSLGGGEIAGLAALPGSGVALALGRDCRLWRATRTSLDLLATLPSPADDCVALQAGPEGAWAASAHAGVFLFAVADGKMRRSLPLQQAAPVTTLLRRGDGSLLIGFRDGRVARLDSATADAPFPLSLDRRLDSSVTTLHEDAAGSLWIGTYTSGLHYARPLSATVRVGRSEAGAPGGWPKASMRAIWRAGDHILLGTDGGLLERRGTAVDWREVPGFDGHSVRAIAREGEGRGGWWIGTHDGLFHWSGRGPARAMDGLPDNRVETLLLEPGGDGWIGTHGGLVRMQAGKIVDDPALAPLRDSQVTALLRMGPRLWIATNANGLWRLDPGQAPARVFPEALHNSLWSLLADDGALWAGSYARGIYRIDLATSAVTNIRHSDGLGNDVIYSMLTDDLGRLWASTNNGLSVIDPGNGSIQVLGPRDGLANREYNSGSAYRDARGLLYFGGTRGVDVLDPSGLPRHSAPARPVLTTLRTSPLDADGGGPREIGIVYDSAAQLAHRDRMITVRMTAIDFAAPDAARLRYRVLGLHDDWVYPHAPTAEFSVTGLPPGGYVLEVEAAGRDGRFGQPRRFGLEMAPPWWRHPVAYVAYALALLLLLGLVVRRVDAAVRRERRQVELLERTVAERTAQLQLANQRLSRANARLSIDTRRDPLTRISNRRDLQEWLGREAAALRSRLEDTNGGGDRLVFLMIDIDDFKQVNDVYGHQAGDEVLVHLADRLRLLSRDDDLLVRWGGEEFLLISRFAHLEDAPQLAERIRAAIAGQPVRIGRGVSLELTCSIGFAPWPFSIEWPDIGDWSACVGLADRCLYTVKRGSKNGWVGVVPGDAPKAEAIQALLAGAHPDDVGEHTVRMLYSGEKPPRLGC
>NZ_CP042218.1|WP_144893510.1|2724501_2725857_-|mechanosensitive-ion-channel
MRPYLRHVRPALLILLLALASAAGVHVLARDAGAGPAPEASTDADLAGSRDLARRLRETDGLRDVTVTVRDGVAELEGVVLDAGDRERAEQVASQQPGISRVENRVILSTRLSERLALATTLAMDKLTRLIAALPLLLVALLVVALAWWAGRWLGRRAGQRIARRNWQSENPYFASLMQQLVQWLALLGGVLVALDLLGATALVGAVMGSAGVIGLALGFAFKDIAENYVAGVLLSIRRPFAPGELLRIDNTHEGRVAALTPRATVLVTHDGNRLTLPNALVFKSVVLNFSSNARRRLEFAVPVDVSESIRCVHELAMEAIRGTDGVLADPGPSWTVDGYDATAITLRFFAWVDQRESDLGKVRSEAIHAVRTRLQQAGISPPRNIQFTASLPAAEVAAPPVAGMTQAPADGTSRGDTSVNRDLDAHLAAEQRAHAGEDLLPGEAGPGRDR
>NZ_CP042218.1|WP_144893508.1|2724066_2724300_-|hypothetical-protein
MVEIKEVAAGFQVSGPGFDEIFQSRFKATMAAHAVALGDATACGHPVAIVVPRGWGGMVLVGPGPAAADGRATRRLD
>NZ_CP042218.1|WP_144893506.1|2722762_2724070_+|TIGR03862-family-flavoprotein
MEQAPPVQGASAAGRRVAVVGGGPAGLFAAETLRAAGCEVHLFEAKGSVGRKFLVAGKGGLNLTHSDPPALFASRYRERADAVARWLAAFDAGALREWALGLGVPTFVGSSGRVFPEDLKAVPLLRGWVRRLRAQGVEIHVHHRWLGWDGDGALRFATDADERRFVPEATVLALGGGSWPQLGSDGTWQEILRREGIEVAPLRPANCGFDVAWSAYFAQRHAGAPLKPVVAHWRDAAGRCHALQGECVVSAHGIEGSLVYAISAELREAIARDGHALLELDLAPGRELDRLRRELSRPRGKRSVSEHLRRAAGLDGAKAGLLREVLDAGAMHDADAVARATKRLPLRLSAPRPLAEAISSAGGLRLEALDDDLMLRARPGVFAAGEMLDWEAPTGGYLLTACFAAGRVAAEGALRWLRVSARPAPGGESGARAGS
>NZ_CP042218.1|WP_168199009.1|2734138_2734315_+|hypothetical-protein
MSWLGLVAIIIGLYLAFKVAGMVLKLALWLLIVVAAYWWLAPLFGWPALEEVIHVLGP
>NZ_CP042218.1|WP_144893526.1|2736269_2737115_-|phosphatidylserine-decarboxylase
MSLVTALTHVLPHRLLSSMARRLAWSDHPRVSRWLIDTVVRRFGVDLEEAADADPAAYPTFNAFFTRALRPGARVPDPDPAAILMPADGRISQCGPIEDGRIFQAKGRWFTAAELLGEGAAAAPYDGGLFATVYLSPRDYHRVHMPWSGRLLRTVHVPGRLFSVGPRAVAKVPRLFARNERLVCHFETDFGPMAVVMVGALLVSGVETVWSGEEIPAYGDRVTGKDYADSTVELARFDEMARFNYGSTVIVLLPPGVAALAPGLGAETPVKLGQRLATRTS
>NZ_CP042218.1|WP_144893528.1|2737111_2737756_-|SCO-family-protein
MFNRSVLIVLVVALAAGLGLVASQQWFGRESAPAPELAAVRLFPQPRELPPFALQQSDGTQLVPGELHGHWTLVFLGFTHCPDVCPTTLADLSRAQKEWEPLPEAQRPRVLFVSVDPERDSPDRIGEYAAFFHRDTLAATADIPALEDFARSLSLVFMKAPGPEGAPADAYTIDHSAALAVLDPEGRMAGVVQGPLDPAAIAADLIALTGAPAR
>NZ_CP042218.1|WP_144893530.1|2738895_2740005_+|chorismate-synthase
MNTFGQLLRVTTFGESHGPAIGCVVDGCPPGIPLAPEDFARDLERRATGRTRHTSARREEDAIEILSGVYEGLTTGTPIALLVRNTDARSRDYAAIAGQFRPGHADYAYWQKYGIRDPRGGGRSSARETTMRVAAGVIAKKWLADRHGVRVRGHLAQIGDIMPRSHDWDAVEGNPFFWPDAAQVPELEAYMDALRKSGDSVGARVAVVADGVPPGWGEPVYGKLDAGIAAAMMSINAVKGVEIGDGFASVAQRGSAHRDPMTPAGFLSNHAGGVLGGISSGQQVVCSVAFKPTSSLRLPVAGLDVDGQVVDIVTTGRHDPCVGIRATPICEAMLALELMDQALRHRAQCGDVGEVAPRIPASAGGRDDG
>NZ_CP042218.1|WP_144894183.1|2739997_2740987_+|D-glycerate-dehydrogenase
MAEPRPRVWVSQPLYADLEARLDEWFEVARTPRVTDHAPGAIAAALADADGALVTLNDRIGETEVAGASRLRAVANVGVGYDNLDVAALAARGIVATNTPGVLTETTADFGFALMMAAARRITEAEHWLRDGRWQGWGFHELLGAEIHGSTLGILGMGRIGQGIARRARGFGMRVLYHNRHRLPEAVEEACAATWTTRAALLADSDHLVLVLPYTADNHHIIDAGALAAMKPTATLTNIARGGLVDEGALAEALQSGRLAAAGLDVFEGEPAVDPRLLACRNVVLTPHVASASLPTRRAMVALAVDNLVAAMGFGPDAGHPPSPVTRIP
>NZ_CP042218.1|WP_144893532.1|2741785_2742802_+|aspartate-semialdehyde-dehydrogenase
MDRKYKVAVVGATGAVGETMLSILAERGFPVGELVALASERSAGGMVAFGDDEVMVRDLAGFDPAGVDIALFSAGGAISKEYAPKFAAAGAVVIDNSSAFRLDPDVPLVVAEVNPEMVKQRPRGIIANPNCSTMQMVVALAPIHRRAGIERINVATYQSVSGAGRLALEELGRQTASLLSFQGAEPERFPVQIAFNLIPHIDEFMDNGYTREEMKLVWETRRILGDERIQVNPTAVRVPVFYGHAEALHIETREKLTAGEARALLEAAPGVEVVDERAPGGYPTPVTHASGRDAVFVGRIREDLSHPRGLDLWVVADNIRKGAALNAVQIAELVAGEG
>NZ_CP042218.1|WP_144893534.1|2742886_2744779_+|hypothetical-protein
MKRAIRWAGLCGLLLVLFAGQALALGLGRIEVRSRAGEPLLAEIQVISGDPAELDALRARLASPDTFRRIGLPAPDAMLSELEFAVAMDVRGNPVIRVTTREPVTRPALTFLVEVDWGQGRLVREYSALIDTPQTVAAPSQPAIDAPVAAPSNTIVRGPAPAPAPAAPEEAGPGPAQGPVAVGDARQGSAGKDRAAAAPVPAPAAPRTVPAPPTAAAPAPAPGDRRVAAGETLGEIARQLVDDGIRREQAIVALFRANPEAFIANNLNLVREGAVLRIPDRSEIAGLDLGESRALMREQIAAWRAMAGPAPQPEAAALADEGASGQSADADPRSRAAASPVADARLEIVPPSAAGARQAGIRSGIQAGGEGEMLRQELQQELQQELQQSRETLAASNAEVEELKARVADLERLQAQQARLIELKDSELAAAQERLAETGEAAAAAPETGAPGGGALPWSWIGLGLVLVAVVAWLLARRAPKPTPRPRFDSATLDAAAQAPWGAAGLSGAGEAAVADSAIEPGTTPSPQPAEVAEPGPAWHSRVAVPTGVSVPPPAGEALHASTAAAGEDVAGSRSASPGTLQGGSERIELARAYLDLGDIDTARDLLREVAHAGDPVDRAEASRLLDGIA
>NZ_CP042218.1|WP_144894184.1|2744830_2745664_+|tRNA-pseudouridine(38-40)-synthase-TruA
MRYALGIEYDGGGFLGWQRLTQPGVESTQTLQAALETALSRVADAPVATTCAGRTDAGVHARCNVVHFDSDAGRSPRNWMLGTTSLLPPSMSVRWCREVAPDFNARFSARARRYRYSILNRPVRPALGRQYLAWTRRPLDAGAMHRAAQALVGELDFSSFRTVHCQAPHARRDLQEISVRREGDVVVVEVQANAFLHHMVRNIVGSLLEVGDGSRPGHWIADVLAARDRRRAGPTAPAGGLVFLGPLYPAGCDLPAEVTLGAEGAGASAAFLPFPTP
>NZ_CP042218.1|WP_144893536.1|2745665_2746352_+|phosphoribosylanthranilate-isomerase
MPRTLFRTRIKFCGLTRAGDVRLAGELGVDAVGFVFAHGSPRRVHAREARALREALAPLVDAVAVFRDNTADEVREVVREVKPSLLQFHGDEDDAFCSRFDLPYVKAVAMGAGARVGGAELAAAHPGASAFLFDSHGGGHDGGSGRRFDWSALPTDLERPFLLSGGLAPDNIHDAVAAIQPWGVDVSSGIESSPGRKDGDLMRAFVSEVRRADCRPDHAPAAAHGALR
>NZ_CP042218.1|WP_144893538.1|2746348_2747563_+|tryptophan-synthase-subunit-beta
MTDMPTDFHAFPDARGHFGRHGGRFVAETLAGPLQELAAAYDAARADPAFVAAFEADLADYVGRPSPIYEAVGLSRHVGGARILLKREDLNHTGAHKINNTIGQALLASRMGKTRIIAETGAGQHGVASATVAARLGLECVVYMGATDIERQKINVYRMKLLGATVVPVTSGSATLKDALNEAMRDWVTNVRDTFYIIGTVAGPDPYPRMVRDFNAVVGKEARAQMLARHGRLPDVVTACVGGGSNAIGIFHAFLNDRDVRLVGAEAAGEGIASGHHAASISAGRVGVLHGNRTYVLCDDDGQVIETHSVSAGLDYPGVGPEHAFLADTGRAQYVGVTDDEALEAFHLLARTEGILAALESSHAVAQAIRLAREMPKDAIVLCNLSGRGDKDVHTIAAREGVEV

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP042218.1	800124-800150	2	0.926

1. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to position: 800124-800150, mismatch: 2, identity: 0.926

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tcctgtgggagcggctacagccgcgat	Protospacer
*****..********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP042218_1	1.2|343033|22|NZ_CP042218|CRISPRCasFinder	343033-343054	22	NZ_CP037443	Klebsiella sp. PO552 plasmid p2, complete sequence	55540-55561	2	0.909
NZ_CP042218_1	1.2|343033|22|NZ_CP042218|CRISPRCasFinder	343033-343054	22	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	81110-81131	2	0.909
NZ_CP042218_1	1.2|343033|22|NZ_CP042218|CRISPRCasFinder	343033-343054	22	MN062714	Microbacterium Phage DirtyBubble, complete genome	22835-22856	2	0.909
NZ_CP042218_1	1.3|343078|22|NZ_CP042218|CRISPRCasFinder	343078-343099	22	NZ_CP030761	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence	1120104-1120125	2	0.909
NZ_CP042218_1	1.3|343078|22|NZ_CP042218|CRISPRCasFinder	343078-343099	22	NZ_CP054032	Rhizobium sp. JKLM13E plasmid pPR13E01, complete sequence	920001-920022	2	0.909
NZ_CP042218_1	1.2|343033|22|NZ_CP042218|CRISPRCasFinder	343033-343054	22	NZ_AP022333	Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49a, complete sequence	92739-92760	3	0.864
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	190364-190390	3	0.889
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	185724-185750	4	0.852
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP024896	Amycolatopsis sp. AA4 plasmid unnamed2, complete sequence	28991-29017	4	0.852
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	110158-110184	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	113388-113414	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	144882-144908	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	11678-11704	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	1212000-1212026	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP045329	Labrenzia sp. THAF191b plasmid pTHAF191b_a, complete sequence	352267-352293	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP045345	Labrenzia sp. THAF187b plasmid pTHAF187b_a, complete sequence	53328-53354	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP045335	Labrenzia sp. THAF191a plasmid pTHAF191a_b, complete sequence	104447-104473	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	1011911-1011937	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP023068	Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence	547334-547360	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP023071	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence	972482-972508	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1095335-1095361	5	0.815
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP010410	Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence	185772-185798	6	0.778
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NC_008712	Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence	221026-221052	6	0.778
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_KP289281	Pseudomonas sp. EGD-AKN5 plasmid unnamed, complete sequence	65349-65375	6	0.778
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NC_004956	Pseudomonas sp. ADP atrazine catabolic plasmid pADP-1, complete sequence	65349-65375	6	0.778
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	NZ_CP017563	Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence	260733-260759	6	0.778
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	MN850593	Escherichia phage inoa, complete genome	88890-88916	6	0.778
NZ_CP042218_3	3.1|1579513|27|NZ_CP042218|CRISPRCasFinder	1579513-1579539	27	MG925349	Mycobacterium phage Mendokysei, complete genome	35850-35876	6	0.778
NZ_CP042218_1	1.1|342976|34|NZ_CP042218|CRISPRCasFinder	342976-343009	34	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	159034-159067	8	0.765
NZ_CP042218_1	1.1|342976|34|NZ_CP042218|CRISPRCasFinder	342976-343009	34	NZ_CP034781	Pseudomonas sp. MPC6 plasmid pMPC6-47K, complete sequence	13609-13642	10	0.706
NZ_CP042218_1	1.1|342976|34|NZ_CP042218|CRISPRCasFinder	342976-343009	34	NZ_CP019037	Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence	19842-19875	12	0.647

1. spacer 1.2|343033|22|NZ_CP042218|CRISPRCasFinder matches to NZ_CP037443 (Klebsiella sp. PO552 plasmid p2, complete sequence) position: , mismatch: 2, identity: 0.909

ggcgaccgccttcttcgcgact	CRISPR spacer
ggcgtccgccttcttcgcgacg	Protospacer
**** **************** 

2. spacer 1.2|343033|22|NZ_CP042218|CRISPRCasFinder matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 2, identity: 0.909

ggcgaccgccttcttcgcgact	CRISPR spacer
ggcgaccgccgtcttcgcgacc	Protospacer
********** **********.

3. spacer 1.2|343033|22|NZ_CP042218|CRISPRCasFinder matches to MN062714 (Microbacterium Phage DirtyBubble, complete genome) position: , mismatch: 2, identity: 0.909

ggcgaccgccttcttcgcgact	CRISPR spacer
ggcgaccgccttcttctcgacc	Protospacer
**************** ****.

4. spacer 1.3|343078|22|NZ_CP042218|CRISPRCasFinder matches to NZ_CP030761 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.909

cgtggcggccttcgtcgtggcg	CRISPR spacer
cgtggcggccttcgccgtggcc	Protospacer
**************.****** 

5. spacer 1.3|343078|22|NZ_CP042218|CRISPRCasFinder matches to NZ_CP054032 (Rhizobium sp. JKLM13E plasmid pPR13E01, complete sequence) position: , mismatch: 2, identity: 0.909

cgtggcggccttcgtcgtggcg	CRISPR spacer
cgtggcggccttcgccgtggcc	Protospacer
**************.****** 

6. spacer 1.2|343033|22|NZ_CP042218|CRISPRCasFinder matches to NZ_AP022333 (Methylosinus sp. C49 isolate Methylosinus sp. C49 plasmid pMSC49a, complete sequence) position: , mismatch: 3, identity: 0.864

ggcgaccgccttcttcgcgact	CRISPR spacer
ctcgaccgccttcttcgcgacg	Protospacer
  ******************* 

7. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.889

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tgctgcaggagcggcttcagccgcgac	Protospacer
* ************** *********.

8. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 4, identity: 0.852

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tgccgcaggagcggctgcagccgcgac	Protospacer
* *.************.*********.

9. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP024896 (Amycolatopsis sp. AA4 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.852

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tcctgctggagcggcgacagccgcggc	Protospacer
****** ******** *********..

10. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
gcctgcagcagcggctacacccgcgcc	Protospacer
 ******* ********** ***** .

11. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
cctcgcaggagcggctccagccgcgac	Protospacer
.*..************ *********.

12. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tgtcgcaggagcggcttcagccgcgac	Protospacer
* ..************ *********.

13. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
acgtgtaggagcggcttcagccgcgac	Protospacer
 * **.********** *********.

14. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tcctgcaggagcgggtaaagccggggc	Protospacer
************** ** ***** *..

15. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP045329 (Labrenzia sp. THAF191b plasmid pTHAF191b_a, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
aactgcaggagcggcttcaggcgcgtt	Protospacer
  ************** *** **** *

16. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP045345 (Labrenzia sp. THAF187b plasmid pTHAF187b_a, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
aactgcaggagcggcttcaggcgcgtt	Protospacer
  ************** *** **** *

17. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP045335 (Labrenzia sp. THAF191a plasmid pTHAF191a_b, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
aactgcaggagcggcttcaggcgcgtt	Protospacer
  ************** *** **** *

18. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tcctgcaggagcgggtaaagccggggc	Protospacer
************** ** ***** *..

19. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP023068 (Ensifer sojae CCBAU 05684 plasmid pSJ05684b, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tcctgcaggagcggctgaagccggggc	Protospacer
****************. ***** *..

20. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP023071 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tcctgcaggagcgggtaaagccggggc	Protospacer
************** ** ***** *..

21. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgcaggagcggctacagccgcgat	CRISPR spacer
tcctgcaggagcgggtaaagccggggc	Protospacer
************** ** ***** *..

22. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP010410 (Xanthomonas sacchari strain R1 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgcaggagcggctacagccgcgat	CRISPR spacer
gtttgcaggagcggcttcggccgcgac	Protospacer
 ..************* *.*******.

23. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NC_008712 (Paenarthrobacter aurescens TC1 plasmid pTC1, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgcaggagcggctacagccgcgat	CRISPR spacer
cgttgtaggagcggcttcagccgcgaa	Protospacer
. .**.********** ********* 

24. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_KP289281 (Pseudomonas sp. EGD-AKN5 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgcaggagcggctacagccgcgat	CRISPR spacer
cgttgtaggagcggcttcagccgcgaa	Protospacer
. .**.********** ********* 

25. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NC_004956 (Pseudomonas sp. ADP atrazine catabolic plasmid pADP-1, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgcaggagcggctacagccgcgat	CRISPR spacer
cgttgtaggagcggcttcagccgcgaa	Protospacer
. .**.********** ********* 

26. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to NZ_CP017563 (Paraburkholderia sprentiae WSM5005 plasmid pl1WSM5005, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgcaggagcggctacagccgcgat	CRISPR spacer
cgctgcaggagcggcaacaggcgcggc	Protospacer
. ************* **** ****..

27. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to MN850593 (Escherichia phage inoa, complete genome) position: , mismatch: 6, identity: 0.778

tcctgcaggagcggctacagccgcgat	CRISPR spacer
gggtgcaggagaggctccagccgcgac	Protospacer
   ******** **** *********.

28. spacer 3.1|1579513|27|NZ_CP042218|CRISPRCasFinder matches to MG925349 (Mycobacterium phage Mendokysei, complete genome) position: , mismatch: 6, identity: 0.778

tcctgcaggagcggctacagccgcgat	CRISPR spacer
aagcgctggagcgactacagccgcgat	Protospacer
   .** ******.*************

29. spacer 1.1|342976|34|NZ_CP042218|CRISPRCasFinder matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 8, identity: 0.765

--tatcgggatcttcttcgccgcgctgcctgcgcct	CRISPR spacer
gctgccgg--tcttcctcgccgcgctgcatgcgctc	Protospacer
  *..***  *****.************ *****..

30. spacer 1.1|342976|34|NZ_CP042218|CRISPRCasFinder matches to NZ_CP034781 (Pseudomonas sp. MPC6 plasmid pMPC6-47K, complete sequence) position: , mismatch: 10, identity: 0.706

tatcgggatcttcttcgccgcgctgcctgcgcct	CRISPR spacer
ggtcggggtcttcttcggcgcgctgcaccagctc	Protospacer
 .*****.********* ******** .  **..

31. spacer 1.1|342976|34|NZ_CP042218|CRISPRCasFinder matches to NZ_CP019037 (Massilia putida strain 6NM-7 plasmid unnamed2, complete sequence) position: , mismatch: 12, identity: 0.647

tatcgggatcttcttcgccgcgctgcctgcgcct	CRISPR spacer
cgatcacgtcttcgtcgccgcgctgccagcgcac	Protospacer
.. . . .***** ************* **** .