CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP017514	Mannheimia haemolytica strain 23311 chromosome, complete genome	3 crisprs	cas3,DEDDh,WYL,DinG,cas2,cas1,cas4,cas7,cas8c,cas5,PD-DExK,RT	1	5	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP017514_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017514_1

1100952-1101026

Orphan

Consensus_repeat	Method
TTCTGGTGTCTGCCACCGCTAGG	CRISPRCasFinder

1 spacers

DinG

The CRISPR arrays of NZ_CP017514_1

>merge|NZ_CP017514|1|1100952-1101026|CRISPRCasFinder
TTCTGGTGTCTGCCACCGCTAGGTCTTTATACCCTAGATTAGTATCAGGTCTTTCTGGTGCCTGCCACCGCTAGG

>NZ_CP017514|1|1|1100952-1101026|CRISPRCasFinder
TTCTGGTGTCTGCCACCGCTAGG	TCTTTATACCCTAGATTAGTATCAGGTCT
TTCTGGTGCCTGCCACCGCTAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017514.1\|WP_006250508.1\|1110769_1110991_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017514.1\|WP_006250513.1\|1102383_1102587_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213767
NZ_CP017514.1\|WP_006248319.1\|1093293_1094388_+\|molybdenum-cofactor-guanylyltransferase	unknown	unknown	gnl\|CDD\|237727
NZ_CP017514.1\|WP_006253136.1\|1108951_1109884_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226605
NZ_CP017514.1\|WP_006248321.1\|1092235_1092874_-\|thioredoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|182863
NZ_CP017514.1\|WP_006248320.1\|1092937_1093207_-\|DUF1040-family-protein	unknown	unknown	gnl\|CDD\|368826
NZ_CP017514.1\|WP_006252260.1\|1091111_1092152_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NZ_CP017514.1\|WP_006250506.1\|1111173_1113099_+\|ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl\|CDD\|224120
NZ_CP017514.1\|WP_006250186.1\|1113172_1113538_+\|CidA/LrgA-family-protein	unknown	unknown	gnl\|CDD\|234983
NZ_CP017514.1\|WP_006250514.1\|1101142_1102384_-\|HipA-domain-containing-protein	unknown	unknown	gnl\|CDD\|377920
NZ_CP017514.1\|WP_006250509.1\|1109885_1110683_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224026
NZ_CP017514.1\|WP_006253491.1\|1103386_1103902_-\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|136097
NZ_CP017514.1\|WP_020824074.1\|1089585_1090626_-\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP017514.1\|WP_006252261.1\|1090816_1091110_-\|YfcZ/YiiS-family-protein	unknown	unknown	gnl\|CDD\|367851
NZ_CP017514.1\|WP_020824074.1\|1099714_1100755_+\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP017514.1\|WP_147009554.1\|1104056_1106885_+\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP017514.1\|WP_006252489.1\|1087775_1088333_+\|DUF2857-domain-containing-protein	unknown	unknown	gnl\|CDD\|378591
NZ_CP017514.1\|WP_006249416.1\|1106976_1108710_-\|C4-dicarboxylic-acid-transporter-DauA	unknown	unknown	gnl\|CDD\|183265
NZ_CP017514.1\|WP_006252259.1\|1094442_1098639_-\|autotransporter-domain-containing-protein	unknown	unknown	gnl\|CDD\|367071
NZ_CP017514.1\|WP_006252258.1\|1098787_1099561_+\|D-hexose-6-phosphate-mutarotase	unknown	unknown	gnl\|CDD\|223748

Protein	Function_ID	Function_description	E-value
NZ_CP017514.1\|WP_006250513.1\|1102383_1102587_-\|hypothetical-protein	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	0.00480946
NZ_CP017514.1\|WP_006248319.1\|1093293_1094388_+\|molybdenum-cofactor-guanylyltransferase	gnl\|CDD\|237727	PRK14489, PRK14489, putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional.	0
NZ_CP017514.1\|WP_006253136.1\|1108951_1109884_+\|ABC-transporter-permease	gnl\|CDD\|226605	COG4120, COG4120, ABC-type uncharacterized transport system, permease component [General function prediction only].	1.63801e-98
NZ_CP017514.1\|WP_006248321.1\|1092235_1092874_-\|thioredoxin-domain-containing-protein	gnl\|CDD\|182863	PRK10954, PRK10954, thiol:disulfide interchange protein DsbA.	7.23879e-76
NZ_CP017514.1\|WP_006248320.1\|1092937_1093207_-\|DUF1040-family-protein	gnl\|CDD\|368826	pfam06288, DUF1040, Protein of unknown function (DUF1040). This family consists of several bacterial YihD proteins of unknown function.	8.73032e-44
NZ_CP017514.1\|WP_006252260.1\|1091111_1092152_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	1.11109e-154
NZ_CP017514.1\|WP_006250506.1\|1111173_1113099_+\|ATP-dependent-DNA-helicase	gnl\|CDD\|224120	COG1199, DinG, Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair].	0
NZ_CP017514.1\|WP_006250186.1\|1113172_1113538_+\|CidA/LrgA-family-protein	gnl\|CDD\|234983	PRK01821, PRK01821, hypothetical protein; Provisional.	3.61345e-25
NZ_CP017514.1\|WP_006250514.1\|1101142_1102384_-\|HipA-domain-containing-protein	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	5.96698e-62
NZ_CP017514.1\|WP_006250509.1\|1109885_1110683_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224026	COG1101, PhnK, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	2.67049e-138
NZ_CP017514.1\|WP_006253491.1\|1103386_1103902_-\|single-stranded-DNA-binding-protein	gnl\|CDD\|136097	PRK06863, PRK06863, single-stranded DNA-binding protein; Provisional.	2.51083e-99
NZ_CP017514.1\|WP_020824074.1\|1089585_1090626_-\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.18245e-24
NZ_CP017514.1\|WP_006252261.1\|1090816_1091110_-\|YfcZ/YiiS-family-protein	gnl\|CDD\|367851	pfam04175, DUF406, Protein of unknown function (DUF406). Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterized enzyme specific for gamma proteobacteria.	7.66966e-31
NZ_CP017514.1\|WP_020824074.1\|1099714_1100755_+\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.18245e-24
NZ_CP017514.1\|WP_147009554.1\|1104056_1106885_+\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP017514.1\|WP_006252489.1\|1087775_1088333_+\|DUF2857-domain-containing-protein	gnl\|CDD\|378591	pfam11198, DUF2857, Protein of unknown function (DUF2857). This is a bacterial family of uncharacterized proteins.	2.15508e-72
NZ_CP017514.1\|WP_006249416.1\|1106976_1108710_-\|C4-dicarboxylic-acid-transporter-DauA	gnl\|CDD\|183265	PRK11660, PRK11660, putative transporter; Provisional.	0
NZ_CP017514.1\|WP_006252259.1\|1094442_1098639_-\|autotransporter-domain-containing-protein	gnl\|CDD\|367071	pfam02395, Peptidase_S6, Immunoglobulin A1 protease. This family consists of immunoglobulin A1 protease proteins. The immunoglobulin A1 protease cleaves immunoglobulin IgA and is found in pathogenic bacteria such as Neisseria gonorrhoeae. Not all of the members of this family are IgA proteases, EspP from E. coli O157:H7 cleaves human coagulation factor V and hbp is a hemoglobin protease from E. coli EB1.	0
NZ_CP017514.1\|WP_006252258.1\|1098787_1099561_+\|D-hexose-6-phosphate-mutarotase	gnl\|CDD\|223748	COG0676, COG0676, Uncharacterized enzymes related to aldose 1-epimerase [Carbohydrate transport and metabolism].	2.73894e-101

>NZ_CP017514.1|WP_020824074.1|1099714_1100755_+|IS481-family-transposase
MFYSNNPLIKHKTGLLNLAEELGNISQACKVMGMSRDTFYRYQQAVEQGGVEALLNQNRRVPNLKNRVDEAIEQAVVKFALDNPAFGQVRVSNELRKQGIFVSAGGVRSIWLRHHLANFKQRLIALEKLVAEQGIILSETQVQALERKKEDEIACGEIETAHPGYLGSQDTFYVGNLKGVGRIYQQTFIDTYSKVAFAKLYTMKTAISAADMLNDKVLPYFESQGLPMLRILTDRGSEYCGKVENHDYELYLAINDIEHSKTKVKHPQTNGICERFHKTILQEFYQVAFRKKIYTDLTTLQADLDEWLMYYNHHRTHQGKMCCGRTPMATLLDGKRIWVEKNLSSN
>NZ_CP017514.1|WP_006252258.1|1098787_1099561_+|D-hexose-6-phosphate-mutarotase
MNLSNALKLIKYNELDVLEVNHNKFKAKIALQGAQLLSWQPYNAEQDVLWLSEIEPFRIGSAIRGGIPICYPWFGSIKEPAHGTARIQEWRLVEHTCSDENVGLVFALENKAKMEMMLGETCELYFTHLDPEPAQLALHSYFNIGDIEKVEVQGLPTRCFDKLTDQEVEVPSPRKISENVDCIYPAQAVNFIQDFANQRTIKVEHINATETVLWNPWHNTVSAMTETAYQNMVCVETARINTLLQQNETLGVRVLVR
>NZ_CP017514.1|WP_006252259.1|1094442_1098639_-|autotransporter-domain-containing-protein
MKTKTFTRSYLASFVTIVLSLPAVASVVRNDVDYQYFRDFAENKGPFSVGSMNIDIKDNNGQLVGTMLHNLPMVDFSAMVRGGYSTLIAPQYLVSVAHNTGYKNVQFGAAGYNPDSHHYTYKIVDRNDYEKVQGGLHPDYHTPRLNKLVTEVVPAAVTNAGTSIKPYLNEERFPMFLRAGSGTQALRGKESNKTTGIAGAYEYLTGGTTLQLSKSSPDHWLDYSSNLYQVSYGPLSTYALPGDSGSGSYAYDMNEKRWVLVGVLNFYNGMDNQFNRSAIIRKDFHEKKFAEDIAGTINNTVQNAQFNWTAQGKSSSLSQSNNVQKLNVDLKDSSIANQNTSLPQENHGKTINFNGKDATIVLKQDIDQGAGALNLNANLTIRPETDQTWQGAGIIVGKDKKVNWQVKNPQGDRLSKLGEGTLYVNGRGQNLGDISVGDGIVILNQQADHQGRKQAFNTVGIVSGRPTVVLGSADQVNPDNIYFGFRGGRLDLNGNSIAFKRIQNSDKHARIVNHNRDHISTLIIQGQDPLTSNDLIWGKWASNSPADIYEYTNPYQNKRKDYFRLKGNSRVYYPTNATSNDHWEFLSSNREQAIQKILDAKNLRQRYDTFNGFIGEDASNKTNGILNVVFDTKTEVNTEQDKLKNIYTMSGGFNLNGELTLKGGTLLLSGHPTPHAYDIKNKHDVVRENDWQDSHFTAKNITVNKMAQLYIGRNVNEVNSHFTATDKAKLNLGFINRSTPSCYDSEYTGTTHCEVQAVISDNIFANLATTAIKGNVKLQNHSQLNLGKANLTGSVQADQTTHITLANHSHWLNNGTSQIGHLTMEKGSILSLNDKFATTEIPVRFNKMIIQGNLKGNGRINYTANLAKGESDHLQVDGIAEGNFVLAVRNSTTEANPKSSLNLLSLKNSNQEGNKVSISLENNYVDLGTYRYVLENRNHNYHLFNPLIPNSTSKEMNATSVSSIPKKESVTNVPTLDKKETEQNLTQLQKDFSAHQLENQKAKQSMINAQSELRRLNSQLNVLQKYVNSRRLGYYTQQAVLEQISIIQNKIKQTQTIFNDANATVKLTDQKLEEAKLALGSVNDLVLIKASAPAMQATNQDTSMMNIIQADWISQYANTALSELSAQANSALQISNSLDRQLFKQSDKFNVWSSVEHQKTEHKSDLYRPYKQQTNLTQLGIQMPIDNGLMFGVALSKNHANAEFNEGVNGKSNLLMASLYGKWQSQQGTFISLDGSYGKAKNQLYLFGENHFTRRISSIGANIGHQFDLAGVQIQPTIGARYYHFSGQDYTLGGAKISSPNTHFMTYQAGLKASKTFSLDDWKVEPSITTHYVDASNKRLAVNVNNNNINQRFGRYLKTEAGIRFEHNQWQFDLHAGFINGNEIKKQHFAGVKLGYSW
>NZ_CP017514.1|WP_006248319.1|1093293_1094388_+|molybdenum-cofactor-guanylyltransferase
MSKTIEERISAVILAGGLARRMNGVEKGLQLFEGKPLISHILARLSPQVSDIWLNVNRSIEQYQQLYPAFSYYQDSLPDFQGPLSGMLAGFEQIESDYLLFVPCDTPFMPELLLQKLKTALRINNVQIAYAHDGERPHPTFALIHRSVQEDLKAYLGSNQQQLLAFFQSQKSVAVDFSEQKSAFTNVNTLEDLSRVSQFPVKNLAITGYSGTGKTTLLEKLIPKLTACGIRVGLIKHSHHNVDVDKKGKDSYRLREAGANPTMIVCDERWALMTETKQAVEFSQLIAKFNPQEVDLVFVEGFKHETLPKIQLHRKGIEKPLPELDQWTIATATDYPLERENWLDINNIGGIADFIKNWLENKAS
>NZ_CP017514.1|WP_006248320.1|1092937_1093207_-|DUF1040-family-protein
MKCERLEELLELLGEHWRKNPDLHLIDILQQLSVEVGEPDNFKALSDEVLIYQLKMRNAGKFEPIPGIKKDYEDDFKTALLRARGILND
>NZ_CP017514.1|WP_006248321.1|1092235_1092874_-|thioredoxin-domain-containing-protein
MKKLALKTAFVALSALFTFNSTAIAADPTAGKEYIEVRKAPSAQKEVVEFFSFYCPHCYDFELSYKIPSQIKEKLPSDSKLVQYHVNFLGRQSEDLTRAWALAMALGAEDKVKTALFEGAQKDAFKSMDDIRSVFLANGITAEQFDSGINSFAVNGLVNKQVQLAEDFQIRGVPAFFVNGQYQLNLEGFADSSSTNDFIKRYVDAVVFLSKK
>NZ_CP017514.1|WP_006252260.1|1091111_1092152_-|LLM-class-flavin-dependent-oxidoreductase
MTKLSILNLVPIREGQTAKQAVDSMVKLAKHAESIGIERYWIAEHHNMKNLASSATQLLIQHALSHTEKLRVGSGGVMLPNHSPYIVAEQYGTLETLYPNRVELGLGRAPGTDMRTATALRRNAQSLPFPDEISELKGYFEGTNPVSAYPAQGLNVPFYILGSSPESAYLAAERGLPYAFASHFAPRFMDDAVRIYRTHFKPSEVLDKPYVILGVNAIAAETDQEAEQLATTQTQFFLNVVTNAQNYLQPPVESDDKVWENFVKAEIVPHFGPVSFQQNALYNQEKTVVRQMTACSLIGSRESVEQQLKSLKARIEIDEIMAVSYIFDEQKQHQSYTWLKEIADKV
>NZ_CP017514.1|WP_006252261.1|1090816_1091110_-|YfcZ/YiiS-family-protein
MSKTMQQKAADAHNMCKLKGDSMLDNSDRQIAFEAVYDSEEIAVQAVEFFTQKAKSVETEPCDIQSEITPIIDGFLMKMWITFSCQAEVILFQMAVR
>NZ_CP017514.1|WP_020824074.1|1089585_1090626_-|IS481-family-transposase
MFYSNNPLIKHKTGLLNLAEELGNISQACKVMGMSRDTFYRYQQAVEQGGVEALLNQNRRVPNLKNRVDEAIEQAVVKFALDNPAFGQVRVSNELRKQGIFVSAGGVRSIWLRHHLANFKQRLIALEKLVAEQGIILSETQVQALERKKEDEIACGEIETAHPGYLGSQDTFYVGNLKGVGRIYQQTFIDTYSKVAFAKLYTMKTAISAADMLNDKVLPYFESQGLPMLRILTDRGSEYCGKVENHDYELYLAINDIEHSKTKVKHPQTNGICERFHKTILQEFYQVAFRKKIYTDLTTLQADLDEWLMYYNHHRTHQGKMCCGRTPMATLLDGKRIWVEKNLSSN
>NZ_CP017514.1|WP_006252489.1|1087775_1088333_+|DUF2857-domain-containing-protein
MIKTITVNEALIGNALLNIKEGNIHPCLKMGFSEEQLKAINNLSLDEIMDISNSVVSFAKVEINHETFWKLLAIAQANTQQRQIIDRALLLGASIEMLHQYFGLSTSEVSARRQLLGIEEKMGRKAAASDEESTHIWEIWQKYKQKMESLDSQEGLELLCLIAEEGNMNLTVVWKLVSEWQSKHK
>NZ_CP017514.1|WP_006250514.1|1101142_1102384_-|HipA-domain-containing-protein
MMNKRIYVFADWETFSQPELVGVLSSDVVRGKENFRFSYDNEWLSSPYVQQIDPNLYLYPGEQYSTDTQNFHIFLDSCPDRWGRLLMKRREAALASQENRKPKLLIESDYLLGVHDMNRMGALRFKTELNGPFLDNNTRLAAPPLSSLRELEFAAIQLESSDNVDDPDYLKWLHMLISPGSSLGGARPKASVIDELNQLWIAKFPSRYDDYDIALWEYLAYRLAIQAKIEMATCRIERFNQEHHTFLTQRFDRHCGKRRHFTSALTQLGYYDGDYEASYLEIAQFLTESGSNTRIDLAQLWRRIVFNIAISNTDDHLRNHGFIYAQEGWILSPAYDLNPVPLSQGLHLNITDSDNRLDYQLAFDVADFFQLSKQQAVQIYDEVLKEVNNWQNVAKEIGIPRQEQEQMKFAFNV
>NZ_CP017514.1|WP_006250513.1|1102383_1102587_-|hypothetical-protein
MFTQTLLAQRTGLSRVTVRKIMNGDPTVAIGYYLMVLGVLGLEQDFTDVGKDDELGRKLQDIELLRK
>NZ_CP017514.1|WP_006253491.1|1103386_1103902_-|single-stranded-DNA-binding-protein
MAGINKVIIVGNLGNDPEMRTMPNGEAVANISVATSESWTDKNTGERREVTEWHRIVFYRRQAEVCGQYLRKGSQVYVEGRLKTRKWQDQNGQDRYTTEIQGDVLQMLGSRQGNDMGGQQGGWGNSAPAGNSYNQGNSNYGYNQTQSAAPQSKPAPQPEPAMNNFDDDIPF
>NZ_CP017514.1|WP_147009554.1|1104056_1106885_+|excinuclease-ABC-subunit-UvrA
MQHIDIRGARTHNLKNINLTLPRDKFIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRCPDHDVPLAAQTISQMVDRVLEEPEGKRMMLLAPVVKERKGEHVKLLENLTASGYLRARIDGEICDLSDPPALELQKKHTIEVVVDRFKVRADLATRLAESFETALDLSGSTAIIADMDDPNAEEIVFSSSFACPHCGYSLHELEPRLFSFNNPAGACPTCDGLGVEQFFDAKKVVQNEEVSLAAGAIKGWDRRSFYYFGLLKAVAEHYGFDLETPFGQLPKKYQNIILNGTKEEIEFVYVNDRGDKVKRKHAFEGVLNNMARRYKETESNAVREELAKYINNRPCMDCEGSRLRREARYVFLDKTNLPMVSEKSIGEALTFFEELKLAGQKEKIAEKILKEIRERLQFLVNVGLNYLSLSRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLNTLVHLRNLGNTVIVVEHDEDAIRAADHIVDIGPGAGVHGGQVIAQGTAAEIMQIEESITGQFLSGKQKIEIPAQRVPYEPTKLLTLSGASGNNLKKVKLEIPVGLFTCITGVSGSGKSTLVNDTLFLLAQNALNRAENSDVAPYESIDGLSHFDKIIDIDQSPIGRTPRSNPATYTGLFTPIRELFAGTQEARARGYNVGRFSFNVRGGRCEACQGDGVIKVEMHFLPDVYVPCDHCKGKRYNRETLEIRYKGKTIHQVLEMTVEEAREFFAPVPMIARKLQTLMDVGLSYIRLGQSSTTLSGGEAQRVKLATELSKRDTGKTLYILDEPTTGLHFADIKQLLGVLHRLRDQGNTIVVIEHNLDVIKTADWIVDLGPEGGSGGGEIIATGTPEEVAKDKRSHTARFLKEILAKG
>NZ_CP017514.1|WP_006249416.1|1106976_1108710_-|C4-dicarboxylic-acid-transporter-DauA
MLNKWFLTKNAFLAVKPFSALKDALNAGYGKQHLIRDIISGLTVGVIAIPLSMALAIASGVPPQHGLYTAIVAGIVIALTGGSRFNISGPTAAFVVILYPVTQQFGLSGLLMATMLSGGILVLMALLRLGRLIEYIPLPVTLGFTCGIGIVIATLQIKDFLGLSIEKMPEHYLGKLEAIFSALPTINWADTLVGVVTLLVLTRWHKLRLPIPGHLPAVFIGTLLSLLLIHFGQNVATIGSAFHYTLSDGTTGYGIPSVLPEFVLPWNLPNAEGNRIDWNLTTIQALLPAAFSMAMLGAIESLLCAVVCDNMTDTKHHSNNELLAQGLGNIASPFLGGITATAAIARSAANVRSGAVSPISSVVHALLVLFALLFLAKALSYLPLSSMAALLLVVAWNMADIPQIIQLTRRSGKNEIAVLLTCITLTVLFDMVIAITVGVLLASLLFIRTIAEMTKSFEMAHPTDLNDVLVYRISGPLFFAAADNLFADLHNKTVHTDHQIKHIVLQCDAVTVLDAGGIHALTRFVQHMLPHQQLHLCNVQFQPMRMLVRSQKTVNEIPQIQFSSDLESAFDKIRQAN
>NZ_CP017514.1|WP_006253136.1|1108951_1109884_+|ABC-transporter-permease
MDSLIHFLSAFLTNITWIGALELGLIYSLVALGVLISYKILDFPDLTADGSFPLGGAVCVISILNQVDPWLATLYGTLAGAVAGMVTASLHIGFKIEKLLASILMMIALYSINLRIMGMPNIAILGETTIYDVMPIESDLQLALVRLVMTLLVVIIVKGLFDLFFATEIGLAVRATGTNSRMAKAQGIAINKMTILGMAISNALIALGGALYVQSNGGVDISIGVGTIVIGLAAVIIGEAIFSVKRIIWLTFAVIIGSILYRFFIALALNNETLNGIGFGPQDLNLITALLVVIVLVVPRIKHKLLGKRG
>NZ_CP017514.1|WP_006250509.1|1109885_1110683_+|ABC-transporter-ATP-binding-protein
MIELNNLFITFNKGTAIENPVLRGLSLKVEQGEFVSVIGSNGAGKSTLLNAISGDCAVDSGEILIQGNKVNQSTTWQRANQVARVFQDPMAGTCESLTIEENMALAYQRGRKRGLGFAIKRQMRELFKDKLALLGLGLENRLTDQMGRLSGGQRQAVSLLMASLQPSNVLLLDEHTAALDPKTTDFVLELTNKIVREQKLTTLMVTHSMRQALDYGDRTVMLHQGQVAFDVSGEQRQKMDVPDLLQLFQQSRHEQLSDDGLLLGN
>NZ_CP017514.1|WP_006250508.1|1110769_1110991_+|hypothetical-protein
MLSIFKTPVEKETLDDWAKISVDVAKVAILAIPVILFGKEPTLIKLTNLALLVLSIYVFLTLGRKLRQLKEVL
>NZ_CP017514.1|WP_006250506.1|1111173_1113099_+|ATP-dependent-DNA-helicase
MTKYDDKIQHAFSENGLLSQNISGFRPRQAQLEMAQVVAKAVKFATPVVVEAGTGTGKTFAYLVPALLSGKKTILSTGSKNLQDQLFNRDLPTIQKALKYKGKIALLKGRANYLCLERLDQVTAMGVLGDKSVLTDLKKVSKWQNATKTGDLSECITIAEDSPILPQLVSTTESCLGSDCPHFKDCYVVQARRKAMEADVVVVNHHLFCADMAVKETGFGELIPEAELVIFDEAHQLPDIASQYFGQSLSSRQLFDICKDTNIVYRTELKDLSQLGKAADHLTKVVQDFRLLMGGEGQIRGNLRELFRDKKVVDGLVKVAENIDFLSEVAKKSLGRSEMLDKIFERLAEVKVQLKKLMDTSVTGYCYWYEANGRSFGLHITPLMVADKFGEQLKNQQIGWVFTSATLEVGGKFDHFCQRLGIENAEQLVLQSPFDYQHQSLLCVPRYLPDTNKSNTLTALGQLLKPVIEANKGRCFLLCTSYYMMRGLADFLREHSSLNVLLQGETSKSRLLEKFVKEDHSVLVATQSFWEGIDVRGDDLSLVIIDKLPFTSPDEPLLKARMEDCKIQGGDPFNDIQIPEAVITLKQGVGRLIRDVTDRGVVIICDSRLVMRNYGQTFLKSLPPSRRTRDLGNVIQFLKQK
>NZ_CP017514.1|WP_006250186.1|1113172_1113538_+|CidA/LrgA-family-protein
MLSTLLRMVASLALLFVMLYLGKLIVYLFPIGIPDSILGMLILFGCLVIGIVKVEWVIPSAKPLTRYITLFFLPICVELIEHLELLRQNLNTFVLATALSTLVSVVAIGVFAQWIFHYKRG

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Crispr_ID: NZ_CP017514_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017514_2

1522683-1523245

TypeI

Consensus_repeat	Method
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	PILER-CR
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	CRISPRCasFinder
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	CRT

8 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_CP017514_2

>merge|NZ_CP017514|2|1522683-1523245|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATACACAGCCACGCGTAGGTGGCTGCAATTGCCTGTACATCAACATAACCACAAACACGGAGTTTCAATTCACAGCCACGCGTAGGTGGCTGCTCGAAAATCTTCCACGCATTTACGCCGATGTCAGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGCGTTTCAGCACTTGCTCGTCTGTCTAGATGTAAGCGTTTCAATTCACAGCCACGCGTAGGTGGCTGCTAATGCAATGCAGCGAGGGCGAAGAGCTTATCCCTGTTTCAATTCACAGCCACGCGTAGGTGGCTGCACGAATTTACCCCCGAAATGGCCGCCTTGATTGGTTTCAATTCACAGCCACGCGTAGGTGGCTGCTTGGCGCAGATGAAGAGAGCGATAGCGATTTAAGAGTTTCAATTCACAGCCACGCGTAGGTGGCTGCAGGGTGAGAGCCTAGAGCTTTACCGCAAGCGGGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGCTAATCCCCTTGCCTACCATCTCGGAGGAGGTGGTGTTTCAATTCACAGCCACGCGTAGGTGGCTGC

>NZ_CP017514|2|1|1522683-1523245|PILER-CR
GTTTCAATACACAGCCACGCGTAGGTGGCTGC	AATTGCCTGTACATCAACATAACCACAAACACGGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TCGAAAATCTTCCACGCATTTACGCCGATGTCAGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	GTTTCAGCACTTGCTCGTCTGTCTAGATGTAAGC
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATGCAATGCAGCGAGGGCGAAGAGCTTATCCCT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	ACGAATTTACCCCCGAAATGGCCGCCTTGATTG
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TTGGCGCAGATGAAGAGAGCGATAGCGATTTAAGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	AGGGTGAGAGCCTAGAGCTTTACCGCAAGCGGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATCCCCTTGCCTACCATCTCGGAGGAGGTGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC

>NZ_CP017514|2|2|1522683-1523245|CRISPRCasFinder
GTTTCAATACACAGCCACGCGTAGGTGGCTGC	AATTGCCTGTACATCAACATAACCACAAACACGGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TCGAAAATCTTCCACGCATTTACGCCGATGTCAGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	GTTTCAGCACTTGCTCGTCTGTCTAGATGTAAGC
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATGCAATGCAGCGAGGGCGAAGAGCTTATCCCT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	ACGAATTTACCCCCGAAATGGCCGCCTTGATTG
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TTGGCGCAGATGAAGAGAGCGATAGCGATTTAAGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	AGGGTGAGAGCCTAGAGCTTTACCGCAAGCGGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATCCCCTTGCCTACCATCTCGGAGGAGGTGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC

>NZ_CP017514|2|1|1522683-1523245|CRT
GTTTCAATACACAGCCACGCGTAGGTGGCTGC	AATTGCCTGTACATCAACATAACCACAAACACGGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TCGAAAATCTTCCACGCATTTACGCCGATGTCAGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	GTTTCAGCACTTGCTCGTCTGTCTAGATGTAAGC
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATGCAATGCAGCGAGGGCGAAGAGCTTATCCCT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	ACGAATTTACCCCCGAAATGGCCGCCTTGATTG
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TTGGCGCAGATGAAGAGAGCGATAGCGATTTAAGA
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	AGGGTGAGAGCCTAGAGCTTTACCGCAAGCGGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC	TAATCCCCTTGCCTACCATCTCGGAGGAGGTGGT
GTTTCAATTCACAGCCACGCGTAGGTGGCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017514.1\|WP_006250678.1\|1515843_1516254_+\|H-NS-histone-family-protein	unknown	unknown	gnl\|CDD\|182380
NZ_CP017514.1\|WP_006250679.1\|1513874_1515407_-\|Na+/H+-antiporter-NhaC-family-protein	unknown	unknown	gnl\|CDD\|224671
NZ_CP017514.1\|WP_006250672.1\|1525707_1526373_-\|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl\|CDD\|273040
NZ_CP017514.1\|WP_006248812.1\|1518150_1519224_+\|homoserine-O-acetyltransferase	unknown	unknown	gnl\|CDD\|234678
NZ_CP017514.1\|WP_006250674.1\|1523794_1524808_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NZ_CP017514.1\|WP_006250677.1\|1517199_1517883_-\|DUF218-domain-containing-protein	unknown	unknown	gnl\|CDD\|225500
NZ_CP017514.1\|WP_006248118.1\|1520957_1522433_-\|ribonuclease-G	unknown	unknown	gnl\|CDD\|183285
NZ_CP017514.1\|WP_006250667.1\|1532868_1535157_-\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|350688
NZ_CP017514.1\|WP_006250673.1\|1524925_1525606_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP017514.1\|WP_006250681.1\|1511694_1512885_-\|tryptophan-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|235288
NZ_CP017514.1\|WP_020824138.1\|1510886_1511693_-\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|161792
NZ_CP017514.1\|WP_006250676.1\|1519301_1520804_-\|lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
NZ_CP017514.1\|WP_006248107.1\|1529026_1529704_-\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_CP017514.1\|WP_006248114.1\|1523434_1523728_-\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_CP017514.1\|WP_006250669.1\|1529941_1531693_-\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|223510
NZ_CP017514.1\|WP_006250670.1\|1527245_1529030_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09757_cas8c_CAS-I-C	gnl\|CDD\|187887
NZ_CP017514.1\|WP_020824140.1\|1531682_1532738_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238697
NZ_CP017514.1\|WP_006248815.1\|1516323_1517163_+\|formyltetrahydrofolate-deformylase	unknown	unknown	gnl\|CDD\|235676
NZ_CP017514.1\|WP_006250671.1\|1526372_1527236_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	cd09689_cas7_CAS-I-C	gnl\|CDD\|377458
NZ_CP017514.1\|WP_006250680.1\|1512896_1513649_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187604

Protein	Function_ID	Function_description	E-value
NZ_CP017514.1\|WP_006250678.1\|1515843_1516254_+\|H-NS-histone-family-protein	gnl\|CDD\|182380	PRK10328, PRK10328, DNA-binding protein StpA.	1.90925e-33
NZ_CP017514.1\|WP_006250679.1\|1513874_1515407_-\|Na+/H+-antiporter-NhaC-family-protein	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	4.15788e-96
NZ_CP017514.1\|WP_006250672.1\|1525707_1526373_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	5.92936e-41
NZ_CP017514.1\|WP_006248812.1\|1518150_1519224_+\|homoserine-O-acetyltransferase	gnl\|CDD\|234678	PRK00175, metX, homoserine O-acetyltransferase; Provisional.	0
NZ_CP017514.1\|WP_006250674.1\|1523794_1524808_-\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NZ_CP017514.1\|WP_006250677.1\|1517199_1517883_-\|DUF218-domain-containing-protein	gnl\|CDD\|225500	COG2949, SanA, Uncharacterized membrane protein [Function unknown].	3.48782e-75
NZ_CP017514.1\|WP_006248118.1\|1520957_1522433_-\|ribonuclease-G	gnl\|CDD\|183285	PRK11712, PRK11712, ribonuclease G; Provisional.	0
NZ_CP017514.1\|WP_006250667.1\|1532868_1535157_-\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.9519e-57
NZ_CP017514.1\|WP_006250681.1\|1511694_1512885_-\|tryptophan-synthase-subunit-beta	gnl\|CDD\|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_CP017514.1\|WP_020824138.1\|1510886_1511693_-\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|161792	TIGR00262, Tryptophan_synthase_alpha_chain, tryptophan synthase, alpha subunit. Tryptophan synthase catalyzes the last step in the biosynthesis of tryptophan. The alpha chain is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. In bacteria and plants each domain is found on a separate subunit (alpha and beta chains), while in fungi the two domains are fused together on a single multifunctional protein. The signature pattern for trpA contains three conserved acidic residues. [LIVM]-E-[LIVM]-G-x(2)-[FYC]-[ST]-[DE]-[PA]-[LIVMY]-[AGLI]-[DE]-G and this is located between residues 43-58 of the model. The Sulfolobus solfataricus trpA is known to be quite divergent from other known trpA sequences. [Amino acid biosynthesis, Aromatic amino acid family].	2.62732e-123
NZ_CP017514.1\|WP_006250676.1\|1519301_1520804_-\|lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
NZ_CP017514.1\|WP_006248107.1\|1529026_1529704_-\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.38632e-113
NZ_CP017514.1\|WP_006248114.1\|1523434_1523728_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	8.20021e-33
NZ_CP017514.1\|WP_006250669.1\|1529941_1531693_-\|DUF87-domain-containing-protein	gnl\|CDD\|223510	COG0433, COG0433, HerA helicase [Replication, recombination, and repair].	3.53798e-29
NZ_CP017514.1\|WP_006250670.1\|1527245_1529030_-\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|187887	cd09757, Cas8c_I-C, CRISPR/Cas system-associated protein Cas8c. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family.	0
NZ_CP017514.1\|WP_020824140.1\|1531682_1532738_-\|hypothetical-protein	gnl\|CDD\|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	1.63776e-08
NZ_CP017514.1\|WP_006248815.1\|1516323_1517163_+\|formyltetrahydrofolate-deformylase	gnl\|CDD\|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	2.87146e-173
NZ_CP017514.1\|WP_006250671.1\|1526372_1527236_-\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	6.00618e-155
NZ_CP017514.1\|WP_006250680.1\|1512896_1513649_-\|SDR-family-oxidoreductase	gnl\|CDD\|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.41499e-146

>NZ_CP017514.1|WP_006248118.1|1520957_1522433_-|ribonuclease-G
MSSTELLVNVTPSETRVALVENGILKELHIEREAKRGIVGNIYKGRVTRVLPGMQSAFVDIGLEKAAFLHASDIVSHTECVDENEKKQFLVKDISELVREGQDIVVQVVKDPIGTKGARLTTDITLPSRYLVFMPENSHVGVSQRIESEEERARLKSLVEPYCDELGGFIVRTAAEEATEESLKQDVEFLKRLWRKVLERKGKYSAKSMLYGELALAQRVLRDFIGTHINSVRIDSKLTYEQVREFLAEFMPELTDCVTLYTGQQTLFDAYGVEKAIQKALDKRVDLKSGGYLIIEQTEAMTTIDINTGAFVGHRNLAHTIFNTNIEAIQAIAHQLQLRNLGGIIIIDFIDMQEEEHRERVLQSLQEALKGDRVKTNVNGFTQLGLVEMTRKRTRESLERILCCDCQACQGRGTVKTVETVCYEIMREIVRVHHLFKTENIHVYAAKDVAEYLINEESHALLAELQAFIGKKIEIKLEPYYHQEQFDVVVM
>NZ_CP017514.1|WP_006250676.1|1519301_1520804_-|lysine--tRNA-ligase
MSEVENQELDLNGEMLARREKLNKIREQGNAFPNTFRRDALAKDLHAQYDAVEGETLKEQNIQVKVAGRIMLKRVMGKASFFTIQDVSGAIQLYVARDNLSDSVYEEKVSLWDLGDIVGVEGALFKTKTGELTVRCSEVQLLTKSLRPLPDKHHGLTDLETRYRQRYLDLISNEESRRTFMIRSQVVSGIRKFFLERDFIEVETPMLQVIPGGAAAKPFITHHNALDVDMYLRIAPELYLKRLVVGGFERVFELNRNFRNEGVSVRHNPEFTMIEYYQAYADYHDLMDNTEELLRQLALDILGTTDVPYGDYVFDFGKPFERITMHDAIVKYGNGIQREDLDSFEKSVEIAKGLGIEIQKSWGLGSVVNAIFEEVAEHQLIQPTFLMAHPAEISPLARRNDENPEVTDRFELFIGGREIGNGFSELNDAEDQAERFDAQVAAKDAGDDEAMFKDEDFIVALEHGLPPTAGEGLGIDRLAMIFANAPSIRDVILFPAMRQK
>NZ_CP017514.1|WP_006248812.1|1518150_1519224_+|homoserine-O-acetyltransferase
MAQQITLFEDVPLPLTLGGELSPITVAYQTYGRLNAEKSNAVLLCHALTGDAKPYYDSPTEKGWWQDFIGKGLAFDTDKYFFICSNVLGGCKGTTGPASINPKTNKPYGSLFPIITVQDIVNVQKALLDYLEIPQLHAVVGGSFGGMQATQWGISYPDKVRNIINLCSSLTLSAEAIGFNHVMRQAIINDPHFNGGNYYDGIAPDNGLKIARMLGMLTYRTDIQLAKAFGRETKQQGQIWGDHFQVESYLSYQGTKFLGRFDANTYLRLLRALDLYDPALGYENEETALKRIKANYTFVAVTSDQLFKQVDVYKSKQKLEQAGVNLEFHEFHSDFGHDAFLVDYDFFEPMIKAGLAK
>NZ_CP017514.1|WP_006250677.1|1517199_1517883_-|DUF218-domain-containing-protein
MNQTRDRLEKLPLFHKMQQFIIKALKIIAIFPLLGIAILLLVDSLTSYIVRDKIYTDSKQIPYREYAVVLGTAKFYSKDVINQYYKYRLEAAKQLVQEGKVNQLLLSGDNKTPYYNEPKTMTSDLLKMGIATSKIKQDYAGYTTFDSIIRAKKVYKLPPFTIISQKFHCERALFIAKFRDIDAICYAATYPEGAYQVRMREILARSAMVFSLLIGKEPESLEDIRSK
>NZ_CP017514.1|WP_006248815.1|1516323_1517163_+|formyltetrahydrofolate-deformylase
MLQQHKILLTECPDDTGLVAKITNICYKHQLNIIKNSEFVENETKRFFMRTELNGIFNDETLLTDLKFTLPEGSSYKLLPKQRKRIVILVTKEAHCLGDLLMKNYYGGLDVEIAAVIGNHETLKSLVERFDIPFHLVSHENLTRVEHDKLLAEKIDEYSPDYIVLAKYMRVLNPEFVARYPNRVVNIHHSFLPAFIGAKPYHRAYERGVKIIGATAHFVNDELDEGPIIMQNVINVDHTYTAEAMMRAGRDVEKTVLSQALELVLADKVFVYKNKTIIL
>NZ_CP017514.1|WP_006250678.1|1515843_1516254_+|H-NS-histone-family-protein
MSALKSLLNIRSLRALAKDLALEQLKSISEKLDIIIAEKEEEMKQEELEKLKQLESLNKYREMLKQDGLSIDELAELLADKVIKTRKARKALSPRPAKYKFVDANGNEKTWTGQGRTPKALQDALDSGKKLEDFAI
>NZ_CP017514.1|WP_006250679.1|1513874_1515407_-|Na+/H+-antiporter-NhaC-family-protein
MNLVDYSTSLWSVLPALIALILAIVTRKVIISLSIGILFGAFMLTNSNFLDALTYIKNSVVSLVYKGAEEGLNSNNVNIILFLLLLGVLTSLLSISGSNQAFANWAQKKVKGKRGAKLMAAGLVFFTFIDDYFHSLAVGAIARPVTDKFRVSRAKLAYILDSTAAPMCVLMPISSWGAYIITLIAGLLATHSITGYSPLGAFMTMSAMNFYAIFAMIMVFFVAYFSFDIGSMARFERQAAHLAELDDEQIETKGHVRDLILPIIALIVATVSMMMKTGADALAESGASFSILGAFENTTVGISLVVGGVAGLIVATICIITSGNISFKNYVRAYGLGVKMMSGAITILFFAWTINGVVSDMQTGKYLSGLVAESIGAEFLPAILFVLAAAMAFSTGTSWGTFGIMLPIGASMAVHSDPALIIPCLSAVMAGAVCGDHCSPVSDTTILSSTGAQCNHMDHVISQLPYALLVATASIVGYLVVGFTQSAVLGFIATAIVMAILILLFKEKKH
>NZ_CP017514.1|WP_006250680.1|1512896_1513649_-|SDR-family-oxidoreductase
MKIALVTGVTAGFGLAICKLLLQSGYKVIGTGRRAERLEELHLQFGDKFLPLAFDIQQPDEVEKALNSRPKAWQQIDLLVNNAGLALGLEPAQKADLNDWYQMIDTNIKGLVTMTRLVLPEMVERNSGHIINIGSIAGTYPYPGGNVYGGTKAFVKQFSLNLRADLAGTKVRVSNVEPGLCGGTEFSNVRFKGDDEKAAKVYENVQFVRPEDVANIVLWLNQQPEHVNINRVEVMPVAQTSSALNVARNI
>NZ_CP017514.1|WP_006250681.1|1511694_1512885_-|tryptophan-synthase-subunit-beta
MSDTLLNPYFGEFGGMYVPEILVPVLKELEQAFVDAQQDPTFQAEFADLLKNYAGRPTALTLCRNLTKGSKTKLYLKREDLLHGGAHKTNQVLGQILLAKRMGKTRIIAETGAGQHGVATALACAMLGMPCVVYMGAKDVERQSPNVFRMRLMGAEVIPVQKGSCSLKDACCEAMRDWAANYDTTHYLIGTAAGPHPFPTMVREFQKMIGEETKRQILAKEDRLPDAVIAAVGGGSNAIGMFADFIEEQSVKLIGVEPAGKGIETGEHGAPLKHGTTGIYFGMKSPIMQDKDGQIEESYSISAGLDFPSVGPQHAYLNATGRAEYVSITDAEALEAFQALAKNEGIIPALESSHALAYALKMIKQNPEKEQLLVVNLSGRGDKDIFTVDKILNGGE
>NZ_CP017514.1|WP_020824138.1|1510886_1511693_-|tryptophan-synthase-subunit-alpha
MSRFDTLFTALKAKNEGAFVPFVTLCDPGFERSFEIIDTMIKNGADALELGFPFSDPLLDGPVIQAANKRALDGGYSTDSCFELIAKIRAKYPDIPIGLLLCANLIFVPIAEVFFQRCQQSGVDAVLIADLPVFAAQEFVPTAEKYGIQPVFICPPNADQNTIERIAQLTQGYTYLVSRAGVTSAENQAHASNLDNLVESLKQTGAAPILQGFGIAKPEQVKEALRLGADGAISGSAIVKIIERNLSNQANLLKELAEFVQVMKAATK
>NZ_CP017514.1|WP_006248114.1|1523434_1523728_-|CRISPR-associated-endonuclease-Cas2
MLMLITYDISFDDPEGQARLRRIAKHCLDYGVRAQYSVFECDVTPAQWVTLKNKLLATYNPDCDSLRFYHLGSKWRNKVEHHGAKPSVDIFKDTLIL
>NZ_CP017514.1|WP_006250674.1|1523794_1524808_-|type-I-C-CRISPR-associated-endonuclease-Cas1
MRKLQNTLYITSQGSYLHKERETLVVEQDRKKVAQLPIHSIGHIFCFGNVLVSPFLMGFCGENNVNLAFFTENGRYLGRLQGRQSGNVLLRRAQYKKSETNPVPVARNIIAAKIQASKRVLQRQIRNHGENADIQLAITALNYSLQQLKIADNLNLIRGIEGDAAARYFGMFSHLIKENSGFHFDGRNRRPPRDGVNALLSFLYSILGKDISGALQGVGLDPQIGFLHADRPGRDSLAQDILEEFRAWWVDRMVLSLINRGQVKPDDFVTEASGAVTLKPEARKLLFQTLQAKKQEKIIHPFLEEEVEIGLLPYIQAMLLARHLRGDLAEYPPFLMR
>NZ_CP017514.1|WP_006250673.1|1524925_1525606_+|hypothetical-protein
MKRRFLFKNYGPDDQTIIQAIQHSVEISRKNNNSNIHIVFPRKSDFESTNLGKIIDQILGAGSAKKLTKGESIGSLDLLLPSRINSSNSSGTILAVYCTSHDMHLIDSNSSADDIIFVSWLPDEANHWENTWHNHGLIIMKGETSLNIPQIPEEIVQSLTNLTAIINLSTGLSHPSDKKHAEQIFKELSQKGYKADEEQIASWAIAHGWNASHLSDLKKLVRRYLS
>NZ_CP017514.1|WP_006250672.1|1525707_1526373_-|CRISPR-associated-protein-Cas4
MDDLQNSTEILPLVQPKFGYDKRSISLSALQHYAFCPRQCALIHNEQVWAENYLTAQGQVLHERVDSGEPETRKGIRFERTVHVAAEKLGISGILDLVERDLKTGELKPVEYKRGKPKPEPMDEIQLCAQALCLEEMTGQTINEGALWYMQTRHRLPITFSTELRTKTLATISEVRSLLNSGTTPLPKYSKRCKACSLIDLCQPQLLDRDRSERYVEEIFK
>NZ_CP017514.1|WP_006250671.1|1526372_1527236_-|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MSIQNRYEFVFFFDVTNGNPNGDPDAGNMPRLDPETSKGLVTDVCLKRKIRNFIEMSYENEAGYEIYVKEKSVLNLQNKRAYEALGIESEAKKLPKEEAKAREITAWMCKNFFDIRTFGAVMTTEVNSGQVRGPVQLAFAQSIDPIIPLEVSITRMAVTNEKDLEKERTMGRKYIVPYALYRVHGFISAKLAEKTGFSDEDVQKLWQALQLMFEHDRSAARGEMAARKLIVFKHDSELGNQPAHKLFDSVKVERINGEKDTPAKDYDDYRISVQAEGLTGVTVEELL
>NZ_CP017514.1|WP_006250670.1|1527245_1529030_-|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MILSALTRYYYRLAAQEDRLTGEAKVPSYGFSEEKIGWVLELDSKGNLVNVISNLTEDKKPKPKLMSVPRPEKRTSGIKPNFLWDKTAYVLGIESNPDKATAKDQPINFAEKTFEAFKQYHLDLLADSNDEGLMAIRNFLQQWQPTHFAESICPREILDANVVFKLVGTSGYIHQREAAQTLWTSLLINQSDNAEKGLCLISGKLSPIQRTHPPIKGVFGGQSSGGSIISFNKESFTSFGKEQGSNAPVSEQAAFAYTTALNYLLRTEKHRLTIGDASTVFWAEADNTTQAEAAEGFFAALMTPPDDEQENQKIFEELQKISKGRPLAEISPELSENTRFYVLGLAPNAARISVRFWLDTTFGQLAKNLSEHWQDLALEPCAWKTPPSIWRLLLQTASLGKSENISPVLAGEMARAVISGHLYPMSLLSQLVTRIRADGDINGLRVALMKAVLQRKFRKGFIKEGVPMSLNKESDNQAYLLGRLFAVLERIQTQALGELNAGIADRYYGSASAVPFSVFPRLLSGAKHHLSRLRKDKGGMAVNLDKDLGEIIASLPENFPRHLSIDEQGRFAIGYYHQKQSYFAKKETTESIEN
>NZ_CP017514.1|WP_006248107.1|1529026_1529704_-|type-I-C-CRISPR-associated-protein-Cas5
MPNKIRLHIWGDYACFTRPEMKVERVSYDVITPSAARGILAAVHWKPAIRWVIDKIYVLQPIQFESVRRNELGSKISASKISGAMKRKTVADLYTVIEDDRQQRAATVLKNVGYVIEAHAVLTKMAGEAETVTKHIEMFKRRAKKGQCFQQPCMGVREFAANFALIDDDEPLPECFLAENERDRDLGWMLHDIDFEHGNQPRFFRAEMKNGVIDVPPFYAEEVKS
>NZ_CP017514.1|WP_006250669.1|1529941_1531693_-|DUF87-domain-containing-protein
MANETLNFKDNARLGRVVTVDTSRVLISVEEHQQMTSIAVGNLIAIQGRTASEYLIGIIERVTRSISEKLLLEEISNEGEIPLGESQDDFIKAVLIGTYKAVDGSLSNTFKRGADCFPQIDRDCFHISGSNLQLFMNLLSANVKENERLTLGHFMADETAVAIANGDKFFQRHAAILGSTGSGKSWSVALILERAAALKAANLIVFDMHGEYSTLCEGKNAIAQQYRIAGPGDLDGSDERSLFIPYWLLNREEMLALILDRSDDNAPNQAARFTEHVRALKEQTLNKEERNDVLETFTVDSPIPYSIELLLARLDKDNSEMVPKEGGSGTKQGPWYSKLSRFMGRMKAKIDDRRCGFMFQPPVECNSYGWLENMLSKLFSASESEKGIKIIDFSEVPSDVLPIVTGVLARLLYNIQFWMDKDSRHPLTIICDEAHLYLPVRDSAEAAEKRALEAFERIAKEGRKYGVSLLVVSQRPSDVSRTILSQCNNFLVLRLTNDQDQSVVKRLLPESMVGITDILPLLDLGEALLLGDSILLPTRIKLAKPHIAPESATRQFWSDWANQEPKPNAVSNAVEALRRQVRS
>NZ_CP017514.1|WP_020824140.1|1531682_1532738_-|hypothetical-protein
MREPLLDEDELKKWLQTIFTDNLVIIVGSGLSCAEGLPGMGALADRLKERMPECLDDIDKVTWNTISDCLDSEGLEGALLKHQANETIEAAIIKITAEYVLSEEQKAINKCIAENQKLKFSYLLPHISASNPKIARVITTNYDRLIEFAAEYENWGIDSMMVGRYWGKHNPDLSRKLQIRDIRVKGKCPKLVYRDHIKIFKPHGSLDWFMAGDVPMTSCIGKVEEPLIITPGVGKYKKGYGQPFDAHREKANEAIDSASSILCIGYGFNDDHLQTHLTGKIKSGVKTLLLTRGLSENARNVVKEAPNCKALIFDGDKAGTRVVSKQEETFIPNVHWWDVEFFVKEILENGK
>NZ_CP017514.1|WP_006250667.1|1532868_1535157_-|CRISPR-associated-helicase/endonuclease-Cas3
MEEHTIQSLYAHSGKLSDHSDWQTLLSHANNVGLLAAEFAAPFASQEIARCTGLLHDLGKYSERYQKRLHGGERVNHSTAGAKIAVERWGPLGKMMAFCIAGHHAGLANGSGEGKNRSTLTQRLQEQFGYGHKDLPVLDAIWQQELNLPEKLPLPPLKPSKNEPFFSYAFFIRMLYSCLVDADFLDTEAFYANLEKRPLERGNSPNLTALHQQFNQFIAQFRERITIQTPNTQEAQRKAEVNRLRSEILDYAVSQVKQETGLFSLTVPTGGGKTFTSMAFALEHAKQYGLCRIIYVIPFTSIIEQNAAEFRKAFGELGEEAVLEHHSTFDHDSLPDKSSRDKLKLASENWDAPVVVTTAVQFFESLFADRSSRCRKLHNIAGSVIILDEAQMLPLNLLRPIMAAIDELARNYQCSVVLCTATQPAIHQANGFYKGFENVREIAPNPTALFEKLKRTTVKHIGIQTDVELQSKLADNPQMLIIVNNRRHARALYDSAKQLEGAYHLTTLMCAKHRSQTLTEIRLRLKQNLPCRVIATSLIEAGVDVDFPLVMRAEAGLDSVAQAAGRCNREGKRLSVESNVWVFQPEEQWKAPPELGLLSGCMRSTVQVHADDLLNPKAINHYFQAVYEAKGKELDKPNILKACHDAGQSLNFPFQKIAEDFRMITSHLIPVIIPFDQEAENLIDRLRYADQVGGILRKLQPYTVQVPEKALAELYNAGRVETINETNFGKQFYCLIGMDLYDEVAGLSWENVDFLESEKLVL

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Crispr_ID: NZ_CP017514_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP017514_3

2056613-2056718

Orphan

Consensus_repeat	Method
ACTGTCAGATTAGGTTTGATCTTCTACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP017514_3

>merge|NZ_CP017514|3|2056613-2056718|CRISPRCasFinder
ACTGTCAGATTAGGTTTGATCTTCTACAAAGCATTTAAGCTCAAATTAATCTGACAGGCACTATAATTTTAAACGGGAACTGTCAGATTAGGTTTGATCTTCTACA

>NZ_CP017514|3|3|2056613-2056718|CRISPRCasFinder
ACTGTCAGATTAGGTTTGATCTTCTACA	AAGCATTTAAGCTCAAATTAATCTGACAGGCACTATAATTTTAAACGGGA
ACTGTCAGATTAGGTTTGATCTTCTACA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP017514.1\|WP_006250395.1\|2058265_2058559_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143393
NZ_CP017514.1\|WP_006250878.1\|2061561_2062335_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-C	unknown	unknown	gnl\|CDD\|235423
NZ_CP017514.1\|WP_006253177.1\|2058551_2058986_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378048
NZ_CP017514.1\|WP_006250397.1\|2056924_2057170_-\|(Na+)-NQR-maturation-NqrM	unknown	unknown	gnl\|CDD\|225538
NZ_CP017514.1\|WP_006252088.1\|2047639_2048917_-\|histidine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234586
NZ_CP017514.1\|WP_020824237.1\|2050137_2051136_-\|DUF4115-domain-containing-protein	unknown	unknown	gnl\|CDD\|236776
NZ_CP017514.1\|WP_020824242.1\|2057182_2058217_-\|FAD:protein-FMN-transferase	unknown	unknown	gnl\|CDD\|224394
NZ_CP017514.1\|WP_006250389.1\|2062327_2063563_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B	unknown	unknown	gnl\|CDD\|235425
NZ_CP017514.1\|WP_147008979.1\|2055544_2056582_+\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|366234
NZ_CP017514.1\|WP_006250406.1\|2047009_2047630_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|225523
NZ_CP017514.1\|WP_020824243.1\|2060337_2060934_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	unknown	unknown	gnl\|CDD\|235074
NZ_CP017514.1\|WP_006250407.1\|2045843_2046947_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|235541
NZ_CP017514.1\|WP_006250404.1\|2048922_2050035_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|234737
NZ_CP017514.1\|WP_006250399.1\|2054073_2054385_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376187
NZ_CP017514.1\|WP_020824238.1\|2052799_2053963_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP017514.1\|WP_006250393.1\|2059097_2060327_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F	unknown	unknown	gnl\|CDD\|235481
NZ_CP017514.1\|WP_020824239.1\|2054688_2055447_+\|IS481-family-transposase	unknown	unknown	gnl\|CDD\|379256
NZ_CP017514.1\|WP_006252085.1\|2051303_2052683_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179883
NZ_CP017514.1\|WP_006250391.1\|2060935_2061562_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D	unknown	unknown	gnl\|CDD\|236457
NZ_CP017514.1\|WP_006250388.1\|2063565_2064924_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-A	unknown	unknown	gnl\|CDD\|235426

Protein	Function_ID	Function_description	E-value
NZ_CP017514.1\|WP_006250395.1\|2058265_2058559_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|143393	cd05403, NT_KNTase_like, Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins. S. aureus KNTase is a plasmid encoded enzyme which confers resistance to a wide range of aminoglycoside antibiotics which have a 4'- or 4''-hydroxyl group in the equatorial position, such as kanamycin A. This enzyme transfers a nucleoside monophosphate group from a nucleotide (ATP,GTP, or UTP) to the 4'-hydroxyl group of kanamycin A. This enzyme is a homodimer, having two NT active sites. The nucleotide and antibiotic binding sites of each active site include residues from each monomer. Included in this subgroup is Escherichia coli AadA5 which confers resistance to the antibiotic spectinomycin and is a putative aminoglycoside-3'-adenylyltransferase. It is part of the aadA5 cassette of a class 1 integron. This subgroup also includes Haemophilus influenzae HI0073 which forms a 2:2 heterotetramer with an unrelated protein HI0074. Structurally HI0074 is related to the substrate-binding domain of S. aureus KNTase. The genes encoding HI0073 and HI0074 form an operon. Little is known about the substrate specificity or function of two-component NTs. The characterized members of this subgroup may not be representive of the function of this subgroup. This subgroup belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, co-ordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this subgroup.	1.17974e-11
NZ_CP017514.1\|WP_006250878.1\|2061561_2062335_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-C	gnl\|CDD\|235423	PRK05346, PRK05346, Na(+)-translocating NADH-quinone reductase subunit C; Provisional.	1.35443e-143
NZ_CP017514.1\|WP_006253177.1\|2058551_2058986_-\|hypothetical-protein	gnl\|CDD\|378048	pfam08780, NTase_sub_bind, Nucleotidyltransferase substrate binding protein like. Nucleotidyltransferases (EC 2.7.7) comprise a large enzyme family with diverse roles in polynucleotide synthesis and modification. This domain is structurally related to kanamycin nucleotidyltransferase (KNTase) and forms a complex with HI0073, a sequence homolog of the nucleotide-binding domain of this nucleotidyltransferase superfamily.	6.0995e-37
NZ_CP017514.1\|WP_006250397.1\|2056924_2057170_-\|(Na+)-NQR-maturation-NqrM	gnl\|CDD\|225538	COG2991, COG2991, Uncharacterized protein conserved in bacteria [Function unknown].	7.16881e-29
NZ_CP017514.1\|WP_006252088.1\|2047639_2048917_-\|histidine--tRNA-ligase	gnl\|CDD\|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	0
NZ_CP017514.1\|WP_020824237.1\|2050137_2051136_-\|DUF4115-domain-containing-protein	gnl\|CDD\|236776	PRK10856, PRK10856, cytoskeleton protein RodZ.	6.79277e-35
NZ_CP017514.1\|WP_020824242.1\|2057182_2058217_-\|FAD:protein-FMN-transferase	gnl\|CDD\|224394	COG1477, ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism].	1.20967e-126
NZ_CP017514.1\|WP_006250389.1\|2062327_2063563_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B	gnl\|CDD\|235425	PRK05349, PRK05349, Na(+)-translocating NADH-quinone reductase subunit B; Provisional.	0
NZ_CP017514.1\|WP_147008979.1\|2055544_2056582_+\|IS481-family-transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	2.10737e-24
NZ_CP017514.1\|WP_006250406.1\|2047009_2047630_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|225523	COG2976, COG2976, Uncharacterized protein conserved in bacteria [Function unknown].	4.99834e-50
NZ_CP017514.1\|WP_020824243.1\|2060337_2060934_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	gnl\|CDD\|235074	PRK02830, PRK02830, Na(+)-translocating NADH-quinone reductase subunit E; Provisional.	4.0318e-125
NZ_CP017514.1\|WP_006250407.1\|2045843_2046947_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|235541	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated.	3.14157e-174
NZ_CP017514.1\|WP_006250404.1\|2048922_2050035_-\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|234737	PRK00366, ispG, flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.	0
NZ_CP017514.1\|WP_006250399.1\|2054073_2054385_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	7.26223e-19
NZ_CP017514.1\|WP_020824238.1\|2052799_2053963_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP017514.1\|WP_006250393.1\|2059097_2060327_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F	gnl\|CDD\|235481	PRK05464, PRK05464, Na(+)-translocating NADH-quinone reductase subunit F; Provisional.	0
NZ_CP017514.1\|WP_020824239.1\|2054688_2055447_+\|IS481-family-transposase	gnl\|CDD\|379256	pfam13551, HTH_29, Winged helix-turn helix. This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	1.04126e-17
NZ_CP017514.1\|WP_006252085.1\|2051303_2052683_-\|argininosuccinate-lyase	gnl\|CDD\|179883	PRK04833, PRK04833, argininosuccinate lyase; Provisional.	0
NZ_CP017514.1\|WP_006250391.1\|2060935_2061562_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D	gnl\|CDD\|236457	PRK09292, PRK09292, Na(+)-translocating NADH-quinone reductase subunit D; Validated.	8.22874e-139
NZ_CP017514.1\|WP_006250388.1\|2063565_2064924_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-A	gnl\|CDD\|235426	PRK05352, PRK05352, Na(+)-translocating NADH-quinone reductase subunit A; Provisional.	0

>NZ_CP017514.1|WP_147008979.1|2055544_2056582_+|IS481-family-transposase
MFYSNNPLIKHKTGLLNLAEELGNISQACKVMGMSRDTFYRYQQAVEQGGEALLNQNRRVPNLKNRVDEAIEQAVVKFALDNPAFGQVRVSNELRKQGIFVSAGGVRSIWLRHHLANFKQRLIALEKLVAEQGIILSETQVQALERKKEDEIACGEIETAHPGYLGSQDTFYVGNLKGVGRIYQQTFIDTYSKVAFAKLYTMKTAISAADMLNDKVLPYFESQGLPMLRILTDRGSEYCGKVENHDYELYLAINDIEHSKTKVKHPQTNGICERFHKTILQEFYQVAFRKKIYTDLTTLQADLDEWLMYYNHHRTHQGKMCCGRTPMATLLDGKRIWVEKNLSSN
>NZ_CP017514.1|WP_020824239.1|2054688_2055447_+|IS481-family-transposase
MFYSNNPLIKHKTGLLNLAEELGNISQACKVMGMSRDTFYRYQQAVEQGGVDALLNQNRRVPNLKNRVDEATEQAVVKFAFDNPAFGQVRVSNELRKQGIFISAGGVRSSWLRHNLANFKQRLNALEKAVAEKGIILSENQVQALERKKEDDVACGEIETAHPGYLGSQDTFYVGNLKGVGRIYQQTFIDTYSKVAFAKLYTMKTAISAADMLNDKVLPFFESQGLPMLRILTDRGSEYCGKVENHDYELYL
>NZ_CP017514.1|WP_006250399.1|2054073_2054385_-|nucleotidyltransferase-domain-containing-protein
MPNFGLSERATKTITDILAKYPEVEQAIIYGSRAKGNYREGSDVDLTFKGKDLTYDIVKRIWGDLDDSDSPYLFDLSIYHQLTNANFIEHIDRVGKVFYQREL
>NZ_CP017514.1|WP_020824238.1|2052799_2053963_-|tRNA-2-thiouridine(34)-synthase-MnmA
MTTQLTSKTYDTHFPKLTPEQLAENSKKKVIIGMSGGVDSSVSAFILQQQGYQVEGLFMKNWEEDDDTDYCTAAADLADAQAVADKLGMKLHKINFAAEYWDNVFEYFLAEYKAGRTPNPDILCNKEIKFKAFLEYAAEDLGADYIATGHYVRRTSDDQDAKLLRGLDENKDQSYFLYALNKKQIGQSLFPVGEIEKPIVRVIAEDLGLATAKKKDSTGICFIGERKFKDFLARFLPAQPGEIRTVEGKLVGRHDGLMYHTLGQRKGLGIGGVKGLSEDPFYVVEKDLINNVLIVAQGHDNSALLSSGLIAKQLTWVDMQPLRENLRCTVKTRYRQADIACEIQVLDDETIRVMFDEPQIAVTPGQSAVFYLGEVCLGGGIIESQLK
>NZ_CP017514.1|WP_006252085.1|2051303_2052683_-|argininosuccinate-lyase
MALWGGRFTQQADAKFKYFNNSLRFDYRLAIQDIEGSIGWAKAITSVGILTVAELEQLIAALKEVRAEVESNLTIILKDDAEDIHSWVESKLIEKVGDLGKKLHTGRSRNDQVAVDIKMWCKVQAVALQERIRALQERLVSVAEENQESVMPGYTHLQRAQPVTFAHWCMAYYEMLERDFSRLSDANKRMSTCPLGSGALAGTAYGIDRDLLARDLGFEEATRNSLDSVSDRDHILELLSTASISMMHLSRFAEDLIIFNSGESGFLEMSDRVTSGSSLMPQKKNPDACELIRGKSGRVFGALNGLLTTLKGLPLAYNKDMQEDKEGIFDALETWQACLEIAELVLVDIQVNTERTREAAQQGYANATELADYLVAKGVPFREAHHIVGEAVVYAISKKEPLEALSINEFQQFHHSIGDDVYPILSLESCLEKRCAKGGVNPQRVAEAIAVAKANLASK
>NZ_CP017514.1|WP_020824237.1|2050137_2051136_-|DUF4115-domain-containing-protein
MTESVNSTQAGTALSLGQQLKAAREALNLSITDVAQKTNLKKSHIESLENDIFILQNVAPTFVRGYVRNYVKFLRLPESLISSVNYGEVTIPKEVTKVSSVKPSSNSQGKTLKYLTVLVLLAALGMTLLWWWQGYQKEQENREQFVSSAPVAEVANTATNNDASAQTSVPVQQPIQVSEQPAQVAETVVAAEPALTEKVEPTQAASSPVTQEDVKVVEEVKQADATTAQVEAVNVLQQSQSEQAPTEQPVAVTNDELRIEITGSQSWITVRGAKNKRLAEKLYNNGETLSFNENEQYRLTIGAPANVKVYYKGQEVPLKIDGRVARIRLPLQ
>NZ_CP017514.1|WP_006250404.1|2048922_2050035_-|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MIHQSPIKRRVSKKIYVGNVPVGGDAPITVQSMTNTRTTDVEATVAQIKSLERVGADIVRVSVPTMDAAEAFKAIKQQVSVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRTVVDCARDKNIPIRIGVNAGSLERDLQEKYGEPTPQALLESALRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARAGSVKSAVGLGLLLAEGIGDTLRVSLAADPVEEVKVGFDILKSLRIRSRGINFIACPTCSRQEIDVIATVNELEQRLEDIITPMDVSIIGCVVNGPGEALVSDLGVTGSNKMSGFYLDGVRQKERFDNAKLIDQLEAKIRARVAQQHNRIDIEQIG
>NZ_CP017514.1|WP_006252088.1|2047639_2048917_-|histidine--tRNA-ligase
MAKTIQAIRGMNDCSPSESPLWQWVEQKVRNVLASYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLRPEGTAGCVRAAIERGWIYNNEQRLWYMGPMFRHERPQKGRYRQFHQAGVEVFGIANPEIDAELIILTARLWKELGIDQHVSLQLNSIGSLEARANYRSALVKFLENHTALMNEEEKERLVKNPLRILDTKNEALQNVLNDAPKLLDYLDDDSREHFTQLCALLDAMGIRYEVNPKLVRGLDYYNKTVFEWVTSALALGSQGTVCGGGRYDGLVEQLGGHATQGVGFAMGLERLVLLVQEVNKEIDLPKTVDVYIVFSGEGATLNAFQLAEQIRSELPHVGVMTHCSGGKFQKQFKRADKVEAQIALVIGESEVAEKQVVIKDLRSGAEQITIAQSELIAELSKRF
>NZ_CP017514.1|WP_006250406.1|2047009_2047630_-|tetratricopeptide-repeat-protein
MSNEYLNKTEEQQFEDAKNWFKENGTPILVAIILACAATAGWNFWKNHQLETAQKTSASYQSVMESYLQNPSKNQPLVEKFIADNKDSSYAAFAQFEVAKQAVEKGNFSAAKTALQSVLTYSDSTLQSIARFRLAQIDFQLKSYDEALASLAQIQDKAWELRKQILTGDILAAKGDIPAAKSAYEQAKTTANPQEQTLIDVRLNNL
>NZ_CP017514.1|WP_006250407.1|2045843_2046947_+|DNA-polymerase-III-subunit-beta
MQITITREQLLKPLQQVCGVLSSRPTLPVINNLLLEIEGNRLSLTGTDLEVELTTQAQLLQAVDFAGKFTIPAKKFLDISKSLPDDSVISVQFEEDKAIIKAGRSKFSLATLPASDYPNLMDWKPEVDFSIDQSTLARLIDATQFSMANQDARYFLNGMKFETEGNLLRTVATDGHRLAVCTMVLNQELLTHSVIVPRKAVLELSRLVASNDETVRLEIGSSNIRITMNGIVFTSKLIDGRFPDYRRVLPRNADRILEAETETLKRALMRAAILSNEKFRGVRLTLSNNLLKITANNPEQEEAEEIIDVAYDSPEMEVGFNVSYVLDVLNTLKCQRVRFSLVDSSSSCLIEDCDNSSAEYVIMPMRL
>NZ_CP017514.1|WP_006250397.1|2056924_2057170_-|(Na+)-NQR-maturation-NqrM
METVLLTFGFFVAVIFAMSIGFIVKGKTIKGSCGGITALGMKKMCDCEEPCDNLKSKIADGTADPEEVARFNKEPQFYEVK
>NZ_CP017514.1|WP_020824242.1|2057182_2058217_-|FAD:protein-FMN-transferase
MKKFFLLLIAFFTLSACEKAPEQITLSGKTMGTTYTVKYIDNGEVENLISPEKMKNELDGLLIEVNNQMSTYQQDSEISRFNQAKQANQAVEISQDFAKVVQEAIRLNKVTEGALDVTVGPLVNLWGFGPDKRLNKVPSDEQIAERSAYVGIDKILLEMSSKPKLTKSAANLYLDLSSIAKGFGVDKLAEHLETIGVSNYLVEIGGELRGKGKNLQGLDWRIAIEQPVMTQGQAAQITVPLHNLAMATSGNYRNYFEDEKGNRLSHIIDPKQLRPVNHNLASITVFAPTTMTADGLSTGLFVLGAEKALAVAEREKLAIFLIVKNGDKFETQMSSEFSKLIQSQ
>NZ_CP017514.1|WP_006250395.1|2058265_2058559_-|nucleotidyltransferase-domain-containing-protein
MIDLTESQRQQVLDIFKKYLPDTPVWVFGSRIKGTAKAYSDLDLALITKQPLTIRQQTELELAFTDSDLPFTVDLIDWASCNESFKQIILQRYEVLI
>NZ_CP017514.1|WP_006253177.1|2058551_2058986_-|hypothetical-protein
MEQLDITALENAFNSLEKTIVSLENQAWFNRQEAIIQDTLIAGAIQKFEFVYELSIKMLKRQLKNIESNDTDIDSTEFRDILRMAAQYGLIESPEVWLDYRKMRNITSHTYDQNKAQQVYNGISNFLESTYFLVKQLQKRNSYD
>NZ_CP017514.1|WP_006250393.1|2059097_2060327_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F
MDSNFIFGIIAFTALVLVLAVIILFAKSKLVDSGDITISINNDPEKGITLPAGGKLLGALASKGIFVSSACGGGGSCGQCKVQVKSGGGEILPTELSHISKKEAKEGWRLACQVNVKSSMDVELPEEIFGVKKWECTVISNDNKATFIKELKLQIPEGEEVPFRAGGYIQIEAEPHTVHYKDFDIPKEYHEDWDKFDLWRYTSKVDEHIIRAYSMASYPEEKGIIMLNVRIATPPPRNPDVPPGQMSSYIWSLKPGDKVTISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHIFDQLKRLKSKRKMSFWYGARSEREMFYVEDFDGLQAENDNFKWYVALSDPLPGDREDYFRGFIHNVLYENYLKNHEAPEDCEYYMCGPPVMNAAVIGMLKSLGVEDENILLDDFGG
>NZ_CP017514.1|WP_020824243.1|2060337_2060934_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E
MEHLLSIFVKSVFIENMALSFFLGMCTFLAVSKKVSTAFGLGIAVIVVLGIAVPANQLVYTHVLKEGALVEGVDLSFLNFITFIGVIAALVQILEMILDKFFPALYSALGIFLPLITVNCAIFGGVSFMVQREYNFVESVVYGVGAGTGWMLAIVALAGLTEKMKYSDVPAGLRGLGITFITVGLMALGFMSFSGIQL
>NZ_CP017514.1|WP_006250391.1|2060935_2061562_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D
MADNNNLKKLLLSPIVDNNPIALQILGICSALAVTTQLQTAVVMAIAVSLVTAFSSMFISMIRNYIPNSIRIIVQMAIIASLVILVDQILRAYAYDLSKQLSVFVGLIITNCIVMGRAEAFAMKSGPVESFVDGIGNGLGYGAMLIIVAFLRELIGSGKIFGITILETVQNGGWYQANGLFLLAPSAFFIIGFVIWAIRTWKPEQVEK
>NZ_CP017514.1|WP_006250878.1|2061561_2062335_-|Na(+)-translocating-NADH-quinone-reductase-subunit-C
MAKFNKDSVGGTLTVVVLLSLICSLIVAGAAVMLKPTQDIQKQLDKQKNILQAAGLLQKDTNVQETYTKFIEPKIVDLATGDYVEGVTGFDARAAAKDPAQNVVIAPEDDKANIKTRAKYAEVYLVKDESGKTTQVVLPMHGNGLWSIMYGFVAVQPDANTVNGITYYEQGETAGLGGEIVNPNWQKNFVGKKLYNEQNQVALRVGKGASADKDHGVDGLSGATLTSNGVDGSFKYWFGQNGFGPYLAKFKAAAGAN
>NZ_CP017514.1|WP_006250389.1|2062327_2063563_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B
MGLKNLFEKMEPAFHKGGKYEKWYTLFEAAYTIFYTPGTVTRKDAHVRDAIDSKRMMLIVWLALFPAMFYGMYNVGAQGILAALKMGTLTDLVANNWHYSLADSLGSVADAGWGTKMLLGATYFLPIYLTVFAVGGFWEVVFAMVRKHEINEGFFVTSILLALIVPPTLPLWQAALATTFGVVVAKEVFGGVGKNFMNPALAGRAFLFFAYPGQISGDAVWVAADGFSGATALSQWAVGGQGALQHVATGETITWMDAFLGNIPGSIGETSTLMLIIGAAIIVFARIASWRIIAGVMIGMAATATLFNVIGSDTNPLFSMPWHWHLVLGGFAIGMFFMATDPVSAAFTNKGKWAYGILIGFMCVLIRVVNPAYPEGMMLAILFANLFAPIFDYLVVQGNIKRRLARVANNG
>NZ_CP017514.1|WP_006250388.1|2063565_2064924_-|Na(+)-translocating-NADH-quinone-reductase-subunit-A
MITIKKGLDLPIAGKPEQVIHNGNTVTEVAMLGEEYVGMRPSMKVREGDVVKKGQVLFEDKKNPGVVFTAPASGTVTAINRGEKRVLQSVVIKVEGDEQITFARYEASQLASLTSEQVKQNLVESGLWTAFRTRPFSKVPALDAEPSSIFVNAMDTNPLAANPEVIIAEHQQAFFDGLTVLSRLFESKKVIHLCGSADSNILNAAQSRQINNVETNRFKGPHPAGLSGTHIHFIDPVGATKQVWYLNYQDVIAIGKLFTTGELFTDRVVALAGPQVKNPRLVRTRLGANLSQLTANELNAGENRVISGSVLSGAIATGVHDYLGRYALQVSALLEGREKAFFGMIAPYSDKYSITRTTLGHFAKKLFNFTTAVHGSERAMVPTGAYERVMPLDIIPTLLLRDLAAGDTDSAQALGCLELDEEDLALCTFVCSGKNNWGPLLRQALDKIEKDG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP017514_3	3.1\|2056641\|50\|NZ_CP017514\|CRISPRCasFinder	2056641-2056690	50	NZ_CP017514.1	750725-750774	0	1.0
NZ_CP017514_3	3.1\|2056641\|50\|NZ_CP017514\|CRISPRCasFinder	2056641-2056690	50	NZ_CP017514.1	1724334-1724383	0	1.0
NZ_CP017514_3	3.1\|2056641\|50\|NZ_CP017514\|CRISPRCasFinder	2056641-2056690	50	NZ_CP017514.1	1297766-1297815	1	0.98

1. spacer 3.1|2056641|50|NZ_CP017514|CRISPRCasFinder matches to position: 750725-750774, mismatch: 0, identity: 1.0

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	Protospacer
**************************************************

2. spacer 3.1|2056641|50|NZ_CP017514|CRISPRCasFinder matches to position: 1724334-1724383, mismatch: 0, identity: 1.0

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	Protospacer
**************************************************

3. spacer 3.1|2056641|50|NZ_CP017514|CRISPRCasFinder matches to position: 1297766-1297815, mismatch: 1, identity: 0.98

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
*****************************.********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP017514_2	2.1\|1522715\|35\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522715-1522749	35	NC_028853	Mannheimia phage vB_MhS_535AP2, complete genome	31900-31934	0	1.0
NZ_CP017514_2	2.1\|1522715\|35\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522715-1522749	35	KP137439	Mannheimia phage vB_MhS_3927AP1, complete genome	33856-33890	0	1.0
NZ_CP017514_2	2.1\|1522715\|35\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522715-1522749	35	NC_028956	Mannheimia phage vB_MhS_1152AP2, complete genome	33963-33997	0	1.0
NZ_CP017514_2	2.3\|1522849\|34\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522849-1522882	34	NC_028853	Mannheimia phage vB_MhS_535AP2, complete genome	34963-34996	1	0.971
NZ_CP017514_2	2.3\|1522849\|34\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522849-1522882	34	KP137439	Mannheimia phage vB_MhS_3927AP1, complete genome	36919-36952	1	0.971
NZ_CP017514_2	2.3\|1522849\|34\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522849-1522882	34	NC_028956	Mannheimia phage vB_MhS_1152AP2, complete genome	37026-37059	1	0.971
NZ_CP017514_3	3.1\|2056641\|50\|NZ_CP017514\|CRISPRCasFinder	2056641-2056690	50	NC_007800	Bibersteinia trehalosi plasmid pCCK13698, complete sequence	913-962	1	0.98
NZ_CP017514_3	3.1\|2056641\|50\|NZ_CP017514\|CRISPRCasFinder	2056641-2056690	50	NZ_CP018033	Glaesserella parasuis D74 plasmid pD74, complete sequence	6036-6085	2	0.96
NZ_CP017514_3	3.1\|2056641\|50\|NZ_CP017514\|CRISPRCasFinder	2056641-2056690	50	NZ_CP054196	Glaesserella parasuis strain YHP170504 plasmid unnamed2, complete sequence	1676-1725	2	0.96
NZ_CP017514_3	3.1\|2056641\|50\|NZ_CP017514\|CRISPRCasFinder	2056641-2056690	50	NC_006829	Haemophilus parasuis plasmid pHS-Rec, complete sequence	8881-8930	2	0.96
NZ_CP017514_1	1.1\|1100975\|29\|NZ_CP017514\|CRISPRCasFinder	1100975-1101003	29	MH791397	UNVERIFIED: Enterococcus phage EfsSzw-1, complete genome	22354-22382	5	0.828
NZ_CP017514_2	2.1\|1522715\|35\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522715-1522749	35	NZ_CP020003	Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed1, complete sequence	42539-42573	10	0.714
NZ_CP017514_2	2.2\|1522782\|35\|NZ_CP017514\|PILER-CR,CRISPRCasFinder,CRT	1522782-1522816	35	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	627317-627351	10	0.714

1. spacer 2.1|1522715|35|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to NC_028853 (Mannheimia phage vB_MhS_535AP2, complete genome) position: , mismatch: 0, identity: 1.0

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
aattgcctgtacatcaacataaccacaaacacgga	Protospacer
***********************************

2. spacer 2.1|1522715|35|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to KP137439 (Mannheimia phage vB_MhS_3927AP1, complete genome) position: , mismatch: 0, identity: 1.0

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
aattgcctgtacatcaacataaccacaaacacgga	Protospacer
***********************************

3. spacer 2.1|1522715|35|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to NC_028956 (Mannheimia phage vB_MhS_1152AP2, complete genome) position: , mismatch: 0, identity: 1.0

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
aattgcctgtacatcaacataaccacaaacacgga	Protospacer
***********************************

4. spacer 2.3|1522849|34|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to NC_028853 (Mannheimia phage vB_MhS_535AP2, complete genome) position: , mismatch: 1, identity: 0.971

gtttcagcacttgctcgtctgtctagatgtaagc	CRISPR spacer
gtttcggcacttgctcgtctgtctagatgtaagc	Protospacer
*****.****************************

5. spacer 2.3|1522849|34|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to KP137439 (Mannheimia phage vB_MhS_3927AP1, complete genome) position: , mismatch: 1, identity: 0.971

gtttcagcacttgctcgtctgtctagatgtaagc	CRISPR spacer
gtttcggcacttgctcgtctgtctagatgtaagc	Protospacer
*****.****************************

6. spacer 2.3|1522849|34|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to NC_028956 (Mannheimia phage vB_MhS_1152AP2, complete genome) position: , mismatch: 1, identity: 0.971

gtttcagcacttgctcgtctgtctagatgtaagc	CRISPR spacer
gtttcggcacttgctcgtctgtctagatgtaagc	Protospacer
*****.****************************

7. spacer 3.1|2056641|50|NZ_CP017514|CRISPRCasFinder matches to NC_007800 (Bibersteinia trehalosi plasmid pCCK13698, complete sequence) position: , mismatch: 1, identity: 0.98

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagcatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
*****************************.********************

8. spacer 3.1|2056641|50|NZ_CP017514|CRISPRCasFinder matches to NZ_CP018033 (Glaesserella parasuis D74 plasmid pD74, complete sequence) position: , mismatch: 2, identity: 0.96

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagtatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
***.*************************.********************

9. spacer 3.1|2056641|50|NZ_CP017514|CRISPRCasFinder matches to NZ_CP054196 (Glaesserella parasuis strain YHP170504 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.96

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagtatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
***.*************************.********************

10. spacer 3.1|2056641|50|NZ_CP017514|CRISPRCasFinder matches to NC_006829 (Haemophilus parasuis plasmid pHS-Rec, complete sequence) position: , mismatch: 2, identity: 0.96

aagcatttaagctcaaattaatctgacaggcactataattttaaacggga	CRISPR spacer
aagtatttaagctcaaattaatctgacagacactataattttaaacggga	Protospacer
***.*************************.********************

11. spacer 1.1|1100975|29|NZ_CP017514|CRISPRCasFinder matches to MH791397 (UNVERIFIED: Enterococcus phage EfsSzw-1, complete genome) position: , mismatch: 5, identity: 0.828

tctttataccctagattagtatcaggtct	CRISPR spacer
gccttataccctagattattatgaggttt	Protospacer
 *.*************** *** ****.*

12. spacer 2.1|1522715|35|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP020003 (Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.714

aattgcctgtacatcaacataaccacaaacacgga	CRISPR spacer
tctcttttgttcatcaacataaccataaacacgat	Protospacer
  *. ..*** **************.*******.

13. spacer 2.2|1522782|35|NZ_CP017514|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 10, identity: 0.714

tcgaaaatcttccacgcatttacgccgatgtcagt	CRISPR spacer
aagaaaatcttccacccatttacgctgatcctttg	Protospacer
  ************* *********.*** ..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

749704 : 835363

Mannheimia_phage(67.24%)

tail,transposase,integrase,plate,tRNA,head

attL 792935:792950|attR 812749:812764

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147009548.1\|749704_750745_+\|transposase	IS481 family transposase	A0A0M3LQ52	Mannheimia_phage	1.4e-199	98.8
WP_051138299.1\|750868_751429_+	hypothetical protein	NA	NA	NA	NA
WP_020831169.1\|751409_753341_+	DUF262 domain-containing protein	NA	NA	NA	NA
WP_006253059.1\|753483_753666_-	hypothetical protein	NA	NA	NA	NA
WP_080542692.1\|753815_754856_+	selenide, water dikinase SelD	NA	NA	NA	NA
WP_006248779.1\|754855_755329_+	NUDIX hydrolase	NA	NA	NA	NA
WP_006251194.1\|755318_756527_+	2-octaprenyl-6-methoxyphenyl hydroxylase	NA	NA	NA	NA
WP_006248781.1\|756789_758022_+	uracil-xanthine permease	NA	NA	NA	NA
WP_006251193.1\|758088_759075_+	dihydroorotate dehydrogenase	NA	NA	NA	NA
WP_006248783.1\|759115_759526_-	DUF2251 domain-containing protein	NA	NA	NA	NA
WP_142782924.1\|759591_760902_-	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	2.0e-131	60.7
WP_020831176.1\|761316_762036_-	helix-turn-helix transcriptional regulator	F6MII3	Haemophilus_phage	2.6e-64	60.0
WP_020831178.1\|762212_762491_+	DNA-binding protein	F6MII4	Haemophilus_phage	2.0e-17	58.8
WP_006251264.1\|764417_765299_+	AAA family ATPase	A0A0M3LP72	Mannheimia_phage	1.7e-155	99.3
WP_020831183.1\|765309_765558_+	hypothetical protein	NA	NA	NA	NA
WP_006251265.1\|765567_765888_+	hypothetical protein	A0A0M3LQH1	Mannheimia_phage	1.8e-41	90.3
WP_005822932.1\|765890_766082_+	hypothetical protein	A0A0M3LQK4	Mannheimia_phage	5.6e-27	95.2
WP_006251266.1\|766094_766712_+	DUF3164 family protein	A0A0M3LQ92	Mannheimia_phage	3.7e-112	99.5
WP_006251267.1\|767030_767243_+	ANR family transcriptional regulator	A0A0M3LSH0	Mannheimia_phage	1.9e-15	85.4
WP_032844828.1\|767248_767431_+	hypothetical protein	A0A0M3LSN0	Mannheimia_phage	5.0e-25	98.3
WP_006251269.1\|767453_768029_+	DUF5420 family protein	A0A0M3LP85	Mannheimia_phage	1.3e-98	93.2
WP_032848912.1\|768041_768410_+	hypothetical protein	F6MIJ4	Haemophilus_phage	1.5e-31	53.0
WP_006251272.1\|768651_769206_+	hypothetical protein	A0A0M3LPP6	Mannheimia_phage	9.7e-96	98.4
WP_020831190.1\|769189_769612_+	regulatory protein GemA	A0A0M3LP80	Mannheimia_phage	3.3e-72	97.1
WP_020831192.1\|769967_770567_+	antirepressor	A0A0R6PJV6	Moraxella_phage	8.7e-26	55.0
WP_006251275.1\|770577_770784_+	hypothetical protein	NA	NA	NA	NA
WP_006251276.1\|770876_771767_+	hypothetical protein	NA	NA	NA	NA
WP_142782968.1\|771894_772326_+	mor transcription activator family protein	A0A0M3LRS6	Mannheimia_phage	1.3e-50	68.5
WP_006248646.1\|772411_772945_+	glycoside hydrolase family 108 protein	A0A0M3LSH2	Mannheimia_phage	5.6e-101	100.0
WP_020831193.1\|772947_773190_+	DUF2644 domain-containing protein	A0A0M3LSN9	Mannheimia_phage	3.2e-35	91.4
WP_020831194.1\|773186_773546_+	DUF2681 domain-containing protein	A0A0M3LP93	Mannheimia_phage	3.8e-53	86.6
WP_005606396.1\|773708_773966_+	hypothetical protein	A0A0M3LPQ4	Mannheimia_phage	9.5e-14	100.0
WP_005606393.1\|773965_774220_+	hypothetical protein	A0A0M3LP87	Mannheimia_phage	6.1e-29	100.0
WP_006251281.1\|774227_774728_+	DUF1804 family protein	A0A0M3LQI8	Mannheimia_phage	8.8e-80	97.0
WP_020824044.1\|775694_776735_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	4.2e-201	99.7
WP_020831201.1\|777779_779453_+	DUF935 domain-containing protein	A0A0M3LRU4	Mannheimia_phage	1.2e-298	92.8
WP_006251285.1\|779439_780729_+\|head	head morphogenesis protein	B7SDN5	Haemophilus_phage	2.1e-218	85.5
WP_006251286.1\|780876_781293_+	phage virion morphogenesis protein	A0A0M3LSP9	Mannheimia_phage	2.3e-70	96.4
WP_132303683.1\|781289_781508_-	hypothetical protein	NA	NA	NA	NA
WP_020831206.1\|781551_782619_+	hypothetical protein	A0A0M3LPA7	Mannheimia_phage	1.1e-183	93.2
WP_006251289.1\|782618_783536_+\|tail	tail sheath protein	B7SDP1	Haemophilus_phage	5.6e-149	84.9
WP_115262444.1\|783581_783899_+	hypothetical protein	A0A0M3LPR6	Mannheimia_phage	1.9e-27	90.8
WP_006248659.1\|783898_784324_+	DUF1320 domain-containing protein	A0A0M3LP98	Mannheimia_phage	4.0e-73	100.0
WP_006248660.1\|784320_784962_+	DUF1834 family protein	A0A0M3LQJ7	Mannheimia_phage	4.0e-117	100.0
WP_006248661.1\|784962_785142_+	DUF2635 domain-containing protein	A0A0M3LQM9	Mannheimia_phage	2.2e-25	100.0
WP_020831214.1\|785141_786551_+\|tail	tail sheath protein	A0A0M3LQC3	Mannheimia_phage	7.6e-254	99.4
WP_006251294.1\|786561_786936_+\|tail	phage tail protein	A0A0M3LRV6	Mannheimia_phage	3.3e-63	99.2
WP_006251295.1\|786935_787304_+	hypothetical protein	A0A0M3LSI2	Mannheimia_phage	1.0e-61	98.4
WP_006251296.1\|787333_787522_+	hypothetical protein	A0A0M3LSQ8	Mannheimia_phage	2.2e-28	100.0
WP_006251297.1\|787574_789854_+\|tail	phage tail tape measure protein	A0A0M3LPB6	Mannheimia_phage	0.0e+00	95.5
WP_006251298.1\|789853_791146_+	hypothetical protein	A0A0M3LQ21	Mannheimia_phage	1.2e-232	95.6
WP_006248665.1\|791148_792276_+	hypothetical protein	A0A0M3LPS4	Mannheimia_phage	1.6e-209	99.7
WP_006251299.1\|792277_792928_+\|plate	phage baseplate assembly protein	A0A0M3LPA3	Mannheimia_phage	6.0e-97	87.4
792935:792950	attL	NA	NA	NA	NA
WP_020831216.1\|793036_793387_+	hypothetical protein	A0A0M3LQK5	Mannheimia_phage	1.2e-59	98.3
WP_020831218.1\|793399_794461_+\|plate	baseplate J/gp47 family protein	A0A0M3LQN4	Mannheimia_phage	1.7e-194	99.7
WP_006251302.1\|794460_795027_+	DUF2313 domain-containing protein	A0A0M3LQE1	Mannheimia_phage	1.9e-70	71.6
WP_147009010.1\|795027_797754_+	hypothetical protein	A0A0M3LS19	Mannheimia_phage	0.0e+00	90.5
WP_061888681.1\|797754_798378_+	DUF4376 domain-containing protein	A0A0M3LRX2	Mannheimia_phage	3.2e-111	96.6
WP_006252023.1\|798370_798835_+	hypothetical protein	F6MIM0	Haemophilus_phage	2.6e-54	63.0
WP_050412813.1\|798955_799744_+	hypothetical protein	F6MIM2	Haemophilus_phage	7.8e-107	68.7
WP_006248925.1\|800335_801100_+\|integrase	site-specific integrase	A0A2H4JBC4	uncultured_Caudovirales_phage	8.0e-08	29.0
WP_006253291.1\|801142_801859_-	DUF3800 domain-containing protein	NA	NA	NA	NA
WP_015484309.1\|803459_805151_+	D-lactate dehydrogenase	NA	NA	NA	NA
WP_006248925.1\|806419_807184_+\|integrase	site-specific integrase	A0A2H4JBC4	uncultured_Caudovirales_phage	8.0e-08	29.0
WP_006250605.1\|807226_807754_-	hypothetical protein	NA	NA	NA	NA
WP_147009009.1\|808525_809062_-	superoxide dismutase family protein	Q9MC02	Salmonella_phage	3.2e-43	52.7
WP_006250609.1\|809311_809893_-	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_006250610.1\|810017_811055_-	beta-N-acetylhexosaminidase	NA	NA	NA	NA
WP_020831228.1\|811180_811912_-	TerC family protein	A0A0R6PEZ3	Moraxella_phage	4.0e-41	47.6
WP_020831229.1\|812000_812681_-	DNA mismatch repair endonuclease MutH	NA	NA	NA	NA
WP_006250537.1\|812772_813408_-	repressor LexA	A0A2H4JG58	uncultured_Caudovirales_phage	7.1e-10	47.1
812749:812764	attR	NA	NA	NA	NA
WP_006250538.1\|813574_816010_+	glycerol-3-phosphate 1-O-acyltransferase PlsB	NA	NA	NA	NA
WP_006250539.1\|816114_816678_-	hypothetical protein	NA	NA	NA	NA
WP_147009008.1\|816875_817664_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_020824074.1\|817805_818846_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	1.4e-201	100.0
WP_006249954.1\|819005_819347_+	carboxymuconolactone decarboxylase family protein	NA	NA	NA	NA
WP_006249955.1\|819357_819711_+	rhodanese-like domain-containing protein	NA	NA	NA	NA
WP_005719747.1\|819770_820409_+	YkgB family protein	NA	NA	NA	NA
WP_020831235.1\|820543_821725_+	formate-dependent phosphoribosylglycinamide formyltransferase	NA	NA	NA	NA
WP_006250543.1\|821816_823310_-	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_132303665.1\|823298_823493_+	hypothetical protein	NA	NA	NA	NA
WP_006253708.1\|823510_825358_+	dihydroxy-acid dehydratase	NA	NA	NA	NA
WP_095578366.1\|825491_825827_-	TusE/DsrC/DsvC family sulfur relay protein	A0A2H4J8B6	uncultured_Caudovirales_phage	2.0e-27	55.9
WP_006253076.1\|825870_826536_-	BAX inhibitor protein	A0A2H4JFM9	uncultured_Caudovirales_phage	1.5e-50	54.3
WP_061888598.1\|826741_827290_+	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_006253077.1\|827367_829206_+	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_006249239.1\|829210_829486_-	hypothetical protein	NA	NA	NA	NA
WP_006249240.1\|829610_829964_-	50S ribosomal protein L20	NA	NA	NA	NA
WP_006249241.1\|830072_830270_-	50S ribosomal protein L35	NA	NA	NA	NA
WP_075270716.1\|830533_831076_-	translation initiation factor IF-3	A0A2L0UZ54	Agrobacterium_phage	1.5e-16	36.4
WP_006249243.1\|831234_833034_-	DNA helicase RecQ	A0A1V0SBK0	Catovirus	2.3e-82	37.4
WP_006249244.1\|833142_833448_-	iron donor protein CyaY	NA	NA	NA	NA
WP_006249245.1\|833458_834250_-	glycosyltransferase family 25 protein	NA	NA	NA	NA
WP_006249246.1\|834331_835363_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	3.4e-110	56.8

DBSCAN-SWA_2

1054631 : 1061416

Mycobacterium_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_031200389.1\|1054631_1055414_+	alpha/beta fold hydrolase	G1DB77	Mycobacterium_phage	1.3e-05	36.4
WP_006252001.1\|1055423_1056152_+	carboxy-S-adenosyl-L-methionine synthase CmoA	H9YRL8	environmental_Halophage	1.2e-21	29.1
WP_006248949.1\|1056287_1057307_+	HTH-type transcriptional repressor PurR	C6ZCU4	Enterobacteria_phage	1.9e-33	32.9
WP_006248950.1\|1057308_1057911_+	DedA family protein	NA	NA	NA	NA
WP_006248951.1\|1058039_1058195_-	DUF1328 domain-containing protein	NA	NA	NA	NA
WP_006248952.1\|1058272_1058854_-	dCTP deaminase	I4AZP2	Saccharomonospora_phage	5.9e-27	38.4
WP_006248953.1\|1058868_1059516_-	uridine kinase	A0A1V0SAA3	Catovirus	4.7e-33	36.6
WP_006248954.1\|1059619_1060249_+	amino acid transporter	NA	NA	NA	NA
WP_006248955.1\|1060363_1061416_+	rod shape-determining protein	F2Y2E1	Organic_Lake_phycodnavirus	1.2e-06	22.1

DBSCAN-SWA_3

1447085 : 1500876

Mannheimia_phage(45.28%)

transposase,integrase,holin,head,terminase

attL 1449660:1449679|attR 1501028:1501047

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_061888680.1\|1447085_1447550_-	hypothetical protein	F6MIM0	Haemophilus_phage	1.7e-53	62.3
WP_061888681.1\|1447542_1448166_-	DUF4376 domain-containing protein	A0A0M3LRX2	Mannheimia_phage	3.2e-111	96.6
WP_147009557.1\|1448166_1451106_-	hypothetical protein	A0A0M3LS19	Mannheimia_phage	0.0e+00	93.4
1449660:1449679	attL	NA	NA	NA	NA
WP_006252064.1\|1451178_1451799_-	DUF2612 domain-containing protein	A0A220NQG4	Acinetobacter_phage	3.7e-27	37.2
WP_006252668.1\|1451795_1452992_-	hypothetical protein	K4I3B4	Acinetobacter_phage	3.0e-62	36.6
WP_006252062.1\|1452988_1453339_-	hypothetical protein	A0A2R3UAP1	Myoviridae_environmental_samples	1.7e-13	39.5
WP_006252669.1\|1453342_1454005_-	hypothetical protein	A0A2R3UAK1	Myoviridae_environmental_samples	2.1e-36	42.0
WP_006252670.1\|1453994_1454882_-	hypothetical protein	K4I0K5	Acinetobacter_phage	3.6e-44	34.2
WP_132303704.1\|1454881_1455178_-	hypothetical protein	NA	NA	NA	NA
WP_020824103.1\|1455180_1455888_-	hypothetical protein	A0A1X9SFH6	Acinetobacter_phage	1.8e-33	45.5
WP_020824105.1\|1456122_1457019_-	hypothetical protein	Q0H8C7	Salmonella_phage	1.4e-35	40.4
WP_006252056.1\|1457303_1457483_-	hypothetical protein	D0UIH9	Aggregatibacter_phage	4.0e-19	84.7
WP_020824044.1\|1458142_1459183_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	4.2e-201	99.7
WP_147009014.1\|1459217_1459514_-	SHOCT domain-containing protein	NA	NA	NA	NA
WP_006252054.1\|1459536_1460199_-	hypothetical protein	NA	NA	NA	NA
WP_020824107.1\|1460198_1462868_-	peptidoglycan-binding protein LysM	A0A1V0DZ47	Acinetobacter_phage	3.3e-64	31.9
WP_020824108.1\|1463040_1463445_-	hypothetical protein	NA	NA	NA	NA
WP_006252051.1\|1463512_1464034_-	ATPase	A0A0M3LR56	Mannheimia_phage	4.4e-34	53.5
WP_006252050.1\|1464168_1464612_-	hypothetical protein	Q8HAQ5	Burkholderia_phage	4.5e-11	35.1
WP_006252049.1\|1464669_1466148_-	DUF3383 domain-containing protein	K4PB47	Acinetobacter_phage	3.9e-99	41.3
WP_006252048.1\|1466163_1466670_-	hypothetical protein	NA	NA	NA	NA
WP_006252047.1\|1466654_1467035_-	hypothetical protein	NA	NA	NA	NA
WP_020824109.1\|1467042_1467747_-	hypothetical protein	NA	NA	NA	NA
WP_006252045.1\|1467749_1468355_-	hypothetical protein	NA	NA	NA	NA
WP_006252044.1\|1468351_1468783_-	DUF4054 domain-containing protein	A0A0S1WH65	Pseudomonas_phage	2.8e-26	45.9
WP_006252043.1\|1468785_1469160_-	hypothetical protein	Q6IWU7	Burkholderia_phage	3.1e-13	36.0
WP_006252679.1\|1469229_1470360_-	DUF2184 domain-containing protein	I6ZXX2	Escherichia_phage	9.9e-79	46.0
WP_006252041.1\|1470371_1470881_-	hypothetical protein	NA	NA	NA	NA
WP_020824111.1\|1470892_1472149_-	DUF2213 domain-containing protein	Q6IWU4	Burkholderia_phage	2.4e-41	40.0
WP_006252039.1\|1472145_1473336_-	hypothetical protein	NA	NA	NA	NA
WP_006252680.1\|1473388_1474219_-\|head	phage head protein	H9C0V1	Aeromonas_phage	8.4e-19	28.7
WP_020824114.1\|1474193_1475705_-	DUF1073 domain-containing protein	I7B6L5	Escherichia_phage	4.3e-114	48.7
WP_020824115.1\|1475772_1477152_-\|terminase	phage terminase large subunit	A0A0D4DCE6	Acinetobacter_phage	4.5e-150	60.9
WP_020824116.1\|1477154_1477652_-	hypothetical protein	C7U0W1	Enterobacteria_phage	8.8e-48	70.4
WP_081107630.1\|1477852_1478032_+	hypothetical protein	A0A0M3LTH4	Mannheimia_phage	2.0e-18	84.9
WP_006252684.1\|1478041_1478191_-	hypothetical protein	A0A0M3LSZ0	Mannheimia_phage	8.8e-20	87.8
WP_006252685.1\|1478219_1478570_-	DUF2570 domain-containing protein	A0A0M3LPB1	Mannheimia_phage	2.3e-26	94.0
WP_020824120.1\|1478570_1479167_-	glycoside hydrolase family 19 protein	A0A0M3LPP0	Mannheimia_phage	8.2e-93	84.3
WP_006251970.1\|1479181_1479625_-\|holin	phage holin, lambda family	A0A0M3ULK9	Salmonella_phage	2.4e-12	36.4
WP_006251969.1\|1479676_1480150_-	hypothetical protein	A0A0M3LPW4	Mannheimia_phage	1.7e-80	96.2
WP_020824122.1\|1480139_1480709_-	recombination protein NinG	A0A0M3LTG3	Mannheimia_phage	5.1e-84	84.7
WP_020824123.1\|1480781_1481243_-	DUF1367 family protein	A0A0M3LPN2	Mannheimia_phage	1.4e-31	45.8
WP_061888672.1\|1481263_1481836_-	adenine methyltransferase	A0A0M3LNW2	Mannheimia_phage	2.1e-106	97.4
WP_075271793.1\|1481846_1482893_-	hypothetical protein	M4SQA9	Psychrobacter_phage	1.1e-23	52.6
WP_006252350.1\|1482889_1483729_-	hypothetical protein	A0A2H4J5H6	uncultured_Caudovirales_phage	2.2e-27	37.4
WP_006252074.1\|1483791_1484235_-	hypothetical protein	NA	NA	NA	NA
WP_006252073.1\|1484283_1484478_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_006252072.1\|1484574_1485234_+	aspartate carbamoyltransferase	NA	NA	NA	NA
WP_006252071.1\|1485233_1486073_+	helix-turn-helix domain-containing protein	A0A1W6JNY2	Morganella_phage	5.2e-16	28.9
WP_006252070.1\|1486089_1486917_+	hypothetical protein	M9NYX6	Enterobacteria_phage	1.8e-58	44.8
WP_142778103.1\|1486932_1487310_-	hypothetical protein	NA	NA	NA	NA
WP_032849124.1\|1487315_1487774_-	hypothetical protein	NA	NA	NA	NA
WP_006252067.1\|1487930_1488227_+	hypothetical protein	NA	NA	NA	NA
WP_142782926.1\|1488692_1488944_+	hypothetical protein	A0A0M3LNV4	Mannheimia_phage	1.1e-30	84.0
WP_006248787.1\|1488946_1489222_-	hypothetical protein	A0A1J0MFQ1	Staphylococcus_phage	1.2e-06	30.4
WP_006252947.1\|1489899_1490415_+	DUF4760 domain-containing protein	NA	NA	NA	NA
WP_020824127.1\|1490681_1491392_+	hypothetical protein	A0A0R6PDL2	Moraxella_phage	8.5e-28	53.5
WP_020824128.1\|1491498_1492005_+	hypothetical protein	A0A0M3LTE5	Mannheimia_phage	1.1e-85	91.1
WP_006252960.1\|1492008_1492368_+	hypothetical protein	A0A0M3LSX3	Mannheimia_phage	2.7e-59	95.8
WP_020824129.1\|1492364_1492844_+	hypothetical protein	A0A0M3LSK4	Mannheimia_phage	3.1e-74	95.0
WP_020824130.1\|1492977_1493190_+	hypothetical protein	A0A0M3LQ55	Mannheimia_phage	8.9e-34	100.0
WP_032848956.1\|1494118_1494781_+	translocation protein TolB precursor	A0A0M3LP90	Mannheimia_phage	4.5e-124	100.0
WP_006252710.1\|1494821_1495088_+	hypothetical protein	A0A0M3LPL3	Mannheimia_phage	2.6e-06	100.0
WP_006252708.1\|1495115_1495568_+	hypothetical protein	A0A0M3LNU4	Mannheimia_phage	1.1e-84	99.3
WP_006252707.1\|1495666_1495885_+	DUF551 domain-containing protein	A0A0M3LS47	Mannheimia_phage	1.7e-32	98.4
WP_061888593.1\|1496579_1497416_+	KilA-N domain-containing protein	Q4ZC41	Staphylococcus_virus	1.7e-75	50.7
WP_020824132.1\|1497801_1498644_+	antirepressor	Q7Y5X0	Haemophilus_phage	1.5e-36	62.8
WP_020824134.1\|1499159_1499543_+	hypothetical protein	A0A0M3LPT1	Mannheimia_phage	9.1e-69	99.2
WP_006247823.1\|1499592_1499814_+	DUF4224 domain-containing protein	A0A0M3LQA2	Mannheimia_phage	1.3e-35	100.0
WP_020824135.1\|1499835_1500876_+\|integrase	tyrosine-type recombinase/integrase	A0A0M3LQJ3	Mannheimia_phage	2.4e-196	96.2
1501028:1501047	attR	NA	NA	NA	NA

DBSCAN-SWA_4

1943517 : 1992474

Mannheimia_phage(58.7%)

tail,transposase,integrase,holin,portal,protease,terminase

attL 1945910:1945925|attR 1991089:1991104

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_020824044.1\|1943517_1944558_+\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	4.2e-201	99.7
WP_006247810.1\|1944630_1944930_-	XRE family transcriptional regulator	NA	NA	NA	NA
WP_006247811.1\|1944901_1945291_-	diaminopimelate decarboxylase	NA	NA	NA	NA
WP_006247812.1\|1945434_1945728_+	hypothetical protein	A0A0M3LSV5	Mannheimia_phage	5.7e-47	99.0
1945910:1945925	attL	NA	NA	NA	NA
WP_020824044.1\|1945997_1947038_-\|transposase	IS481 family transposase	A0A0M3LS26	Mannheimia_phage	4.2e-201	99.7
WP_142782938.1\|1947309_1954443_-	DUF1983 domain-containing protein	A0A0M3LQ28	Mannheimia_phage	0.0e+00	97.3
WP_142782939.1\|1954445_1955036_-\|tail	tail assembly protein	A0A0M3LQ39	Mannheimia_phage	4.9e-98	94.9
WP_020828760.1\|1955304_1956036_-	C40 family peptidase	A0A0M3LQI5	Mannheimia_phage	1.2e-146	99.2
WP_021280070.1\|1956039_1956756_-\|tail	phage minor tail protein L	A0A0M3LPR8	Mannheimia_phage	5.2e-134	97.9
WP_020824199.1\|1956755_1957085_-\|tail	phage tail protein	A0A2R9YJM0	Escherichia_phage	5.3e-17	38.9
WP_142782940.1\|1957084_1960636_-\|tail	phage tail tape measure protein	A0A125RN77	Pseudomonas_phage	1.2e-34	35.4
WP_020824201.1\|1960689_1960917_-	hypothetical protein	NA	NA	NA	NA
WP_020824202.1\|1960979_1961210_-	DUF4035 domain-containing protein	NA	NA	NA	NA
WP_020824203.1\|1961254_1961656_-	hypothetical protein	NA	NA	NA	NA
WP_020824204.1\|1961738_1962380_-	hypothetical protein	NA	NA	NA	NA
WP_020824205.1\|1962407_1962800_-\|tail	phage tail protein	NA	NA	NA	NA
WP_020824206.1\|1962796_1963321_-\|tail	tail protein	M9NZH5	Enterobacteria_phage	4.2e-16	38.1
WP_020824207.1\|1963324_1963627_-\|tail	phage tail protein	NA	NA	NA	NA
WP_020824208.1\|1963619_1963943_-	DUF2190 family protein	K7PLV6	Enterobacteria_phage	2.7e-13	37.4
WP_020824209.1\|1964195_1966157_-\|protease	Clp protease ClpP	A0A1W6JT88	Pseudomonas_phage	1.7e-198	55.2
WP_020824210.1\|1966560_1967757_-	hypothetical protein	NA	NA	NA	NA
WP_020824211.1\|1967760_1969272_-\|portal	phage portal protein	S5MW34	Escherichia_phage	3.7e-158	56.1
WP_015484701.1\|1969271_1969496_-	hypothetical protein	NA	NA	NA	NA
WP_147009560.1\|1969492_1971604_-\|terminase	phage terminase large subunit family protein	A5LH27	Enterobacteria_phage	3.2e-272	67.6
WP_020824213.1\|1971603_1972083_-	DUF1441 family protein	K7PJY2	Enterobacterial_phage	1.2e-41	58.0
WP_015484698.1\|1972352_1972502_-	hypothetical protein	A0A0M3LSZ0	Mannheimia_phage	2.0e-19	85.7
WP_020824214.1\|1972551_1972881_-	DUF2570 domain-containing protein	A0A0M3LPB1	Mannheimia_phage	2.8e-26	100.0
WP_020824215.1\|1972881_1973475_-	glycoside hydrolase family 19 protein	A0A0M3LPP0	Mannheimia_phage	8.2e-109	97.0
WP_041447996.1\|1973464_1973809_-\|holin	phage holin, lambda family	A0A0M3LNX1	Mannheimia_phage	5.9e-59	99.1
WP_006251707.1\|1974156_1974342_-	hypothetical protein	A0A0M3LQD0	Mannheimia_phage	5.2e-30	100.0
WP_006251708.1\|1974850_1975045_+	hypothetical protein	A0A0M3LS93	Mannheimia_phage	2.0e-11	61.9
WP_006252752.1\|1975012_1975453_-	hypothetical protein	A0A0M3LR87	Mannheimia_phage	6.4e-42	63.0
WP_020824218.1\|1975442_1975802_-	RusA family crossover junction endodeoxyribonuclease	A0A0M3LPZ2	Mannheimia_phage	1.3e-13	33.9
WP_020824219.1\|1975794_1976823_-	DUF968 domain-containing protein	S5MW46	Escherichia_phage	5.3e-47	36.7
WP_061888639.1\|1976949_1977543_-	adenine methyltransferase	A0A0M3LNW2	Mannheimia_phage	4.8e-93	81.6
WP_020824125.1\|1977553_1978600_-	hypothetical protein	M4SQA9	Psychrobacter_phage	1.1e-23	52.6
WP_006252350.1\|1978596_1979436_-	hypothetical protein	A0A2H4J5H6	uncultured_Caudovirales_phage	2.2e-27	37.4
WP_006252483.1\|1979611_1979872_-	hypothetical protein	A0A0M3LTF5	Mannheimia_phage	6.2e-37	97.7
WP_006248825.1\|1979892_1980093_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_006252485.1\|1980223_1980907_+	hypothetical protein	K7PKK1	Enterobacteria_phage	1.4e-19	31.1
WP_006248823.1\|1980981_1981362_+	hypothetical protein	A0A0M3LQX0	Mannheimia_phage	1.6e-73	100.0
WP_020824221.1\|1981354_1981852_+	hypothetical protein	A0A0M3LP99	Mannheimia_phage	5.9e-44	97.9
WP_006250075.1\|1981982_1982165_+	type II toxin-antitoxin system HicA family toxin	A0A0M3LQ86	Mannheimia_phage	3.6e-07	51.7
WP_006250984.1\|1982203_1982623_+	type II toxin-antitoxin system HicB family antitoxin	Q7Y3V7	Yersinia_phage	8.5e-28	48.9
WP_006250985.1\|1982689_1982995_-	HigA family addiction module antidote protein	A0A0M3LPV0	Mannheimia_phage	8.6e-54	99.0
WP_006250986.1\|1983003_1983279_-	plasmid maintenance system killer	A0A0M3LQB1	Mannheimia_phage	1.7e-48	100.0
WP_006250987.1\|1983568_1983799_+	hypothetical protein	A0A0M3LQL0	Mannheimia_phage	2.5e-37	98.7
WP_006250988.1\|1984277_1984601_-	hypothetical protein	NA	NA	NA	NA
WP_020824222.1\|1984793_1984979_+	hypothetical protein	NA	NA	NA	NA
WP_006253113.1\|1985132_1985591_+	single-stranded DNA-binding protein	F8TUL2	EBPR_podovirus	9.3e-36	48.7
WP_006250991.1\|1985626_1985986_+	hypothetical protein	A0A192Y6G0	Salmonella_phage	2.8e-19	51.5
WP_020824224.1\|1986057_1986861_+	YfdQ family protein	I3PUY7	Vibrio_phage	1.2e-49	40.1
WP_020824225.1\|1986954_1987389_+	hypothetical protein	S4T7U9	Vibrio_phage	1.6e-05	39.1
WP_020824226.1\|1987398_1987887_+	DUF551 domain-containing protein	A0A0M3LS47	Mannheimia_phage	6.0e-65	74.1
WP_020824227.1\|1987907_1988117_+	hypothetical protein	NA	NA	NA	NA
WP_006248807.1\|1988263_1988389_+	Com family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_020824228.1\|1988435_1989278_+	hypothetical protein	F6MIM2	Haemophilus_phage	6.8e-109	66.5
WP_020824134.1\|1989340_1989724_+	hypothetical protein	A0A0M3LPT1	Mannheimia_phage	9.1e-69	99.2
WP_020824229.1\|1989773_1990049_+	DUF4224 domain-containing protein	A0A0M3LNT7	Mannheimia_phage	1.2e-46	100.0
WP_006251368.1\|1990008_1991064_+\|integrase	tyrosine-type recombinase/integrase	A0A0M3LS39	Mannheimia_phage	2.8e-200	100.0
WP_006249908.1\|1991211_1992474_-	serine hydroxymethyltransferase	A0A240F3L3	Aeromonas_phage	6.9e-97	51.9
1991089:1991104	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP017514

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection