CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP042862	Serinicoccus profundi strain CGMCC 4.5582 chromosome, complete genome	8 crisprs	csa3,cas3,DEDDh,DinG,WYL,cas4	1	3	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP042862_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_1

144957-145089

Orphan

Consensus_repeat	Method
GGGGTGTGTGGTGGGGGTGGGTCGTCAGGGCGACGCGTAGCCACCACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042862_1

>merge|NZ_CP042862|1|144957-145089|CRISPRCasFinder
GGGGTGTGTGGTGGGGGTGGGTCGTCAGGGCGACGCGTAGCCACCACGGAGACGCCCCCGGGGGTGGGTTGGGCGATCTCTGGCAGGGGTGTGTGGTGGGGGTGGGTCGTCAGGGCGACGCGTAGCCACCACG

>NZ_CP042862|1|1|144957-145089|CRISPRCasFinder
GGGGTGTGTGGTGGGGGTGGGTCGTCAGGGCGACGCGTAGCCACCACG	GAGACGCCCCCGGGGGTGGGTTGGGCGATCTCTGGCA
GGGGTGTGTGGTGGGGGTGGGTCGTCAGGGCGACGCGTAGCCACCACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_010149260.1\|134166_134637_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_010149254.1\|138552_139512_+\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
NZ_CP042862.1\|WP_010149243.1\|152700_153471_+\|CHRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377837
NZ_CP042862.1\|WP_010149251.1\|141921_143760_+\|glycoside-hydrolase-family-3-protein	unknown	unknown	gnl\|CDD\|224389
NZ_CP042862.1\|WP_010149255.1\|137253_138546_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP042862.1\|WP_010145995.1\|156857_157652_-\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|180371
NZ_CP042862.1\|WP_010149247.1\|146703_147837_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|379185
NZ_CP042862.1\|WP_141567768.1\|134964_135969_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226450
NZ_CP042862.1\|WP_051125247.1\|148741_151036_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|224137
NZ_CP042862.1\|WP_010149252.1\|140368_141925_+\|DUF3131-domain-containing-protein	unknown	unknown	gnl\|CDD\|370812
NZ_CP042862.1\|WP_010149246.1\|147833_148745_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376014
NZ_CP042862.1\|WP_010149253.1\|139515_140343_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP042862.1\|WP_010149244.1\|151074_152439_-\|amidase	unknown	unknown	gnl\|CDD\|235915
NZ_CP042862.1\|WP_147899704.1\|153486_154266_+\|class-F-sortase	unknown	unknown	gnl\|CDD\|320678
NZ_CP042862.1\|WP_010145997.1\|154269_155934_+\|CopD-family-protein	unknown	unknown	gnl\|CDD\|224195
NZ_CP042862.1\|WP_010145996.1\|155968_156820_-\|formamidopyrimidine-DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
NZ_CP042862.1\|WP_010149256.1\|136169_137177_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP042862.1\|WP_141567767.1\|143975_144908_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_010149258.1\|134623_134968_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_010149248.1\|145141_146413_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_010149247.1\|146703_147837_+\|glycosyltransferase	gnl\|CDD\|379185	pfam13439, Glyco_transf_4, Glycosyltransferase Family 4.	2.69141e-05
NZ_CP042862.1\|WP_010149254.1\|138552_139512_+\|sugar-ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.0517e-88
NZ_CP042862.1\|WP_010149243.1\|152700_153471_+\|CHRD-domain-containing-protein	gnl\|CDD\|377837	pfam07452, CHRD, CHRD domain. CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..	6.31122e-05
NZ_CP042862.1\|WP_010149255.1\|137253_138546_+\|extracellular-solute-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.54822e-104
NZ_CP042862.1\|WP_010149251.1\|141921_143760_+\|glycoside-hydrolase-family-3-protein	gnl\|CDD\|224389	COG1472, BglX, Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism].	5.84198e-48
NZ_CP042862.1\|WP_010145997.1\|154269_155934_+\|CopD-family-protein	gnl\|CDD\|224195	COG1276, PcoD, Putative copper export protein [Inorganic ion transport and metabolism].	4.25728e-15
NZ_CP042862.1\|WP_141567768.1\|134964_135969_-\|hypothetical-protein	gnl\|CDD\|226450	COG3941, COG3941, Mu-like prophage protein [General function prediction only].	3.877e-05
NZ_CP042862.1\|WP_051125247.1\|148741_151036_+\|glycosyltransferase	gnl\|CDD\|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	9.45528e-17
NZ_CP042862.1\|WP_010149252.1\|140368_141925_+\|DUF3131-domain-containing-protein	gnl\|CDD\|370812	pfam10091, Glycoamylase, Putative glucoamylase. The structure of UniProt:Q5LIB7 has an alpha/alpha toroid fold and is similar structurally to a number of glucoamylases. Most of these structural homologs are glucoamylases, involved in breaking down complex sugars (e.g. starch). The biologically relevant state is likely to be monomeric. The putative active site is located at the centre of the toroid with a well defined large cavity.	6.99672e-12
NZ_CP042862.1\|WP_010149253.1\|139515_140343_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.1155e-93
NZ_CP042862.1\|WP_010149244.1\|151074_152439_-\|amidase	gnl\|CDD\|235915	PRK07042, PRK07042, amidase; Provisional.	0
NZ_CP042862.1\|WP_147899704.1\|153486_154266_+\|class-F-sortase	gnl\|CDD\|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	7.91305e-58
NZ_CP042862.1\|WP_010145995.1\|156857_157652_-\|3-oxoacyl-ACP-reductase	gnl\|CDD\|180371	PRK06057, PRK06057, short chain dehydrogenase; Provisional.	2.10578e-179
NZ_CP042862.1\|WP_010145996.1\|155968_156820_-\|formamidopyrimidine-DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	2.04774e-38
NZ_CP042862.1\|WP_010149256.1\|136169_137177_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.13527e-80
NZ_CP042862.1\|WP_010149246.1\|147833_148745_+\|hypothetical-protein	gnl\|CDD\|376014	pfam18588, WcbI, Polysaccharide biosynthesis enzyme WcbI. Capsular polysaccharides (CPSs) are protective structures on the surfaces of many Gram-negative bacteria. wcbI is one of several genes in the CPS biosynthetic cluster whose deletion leads to significant attenuation of the pathogen. Structural analysis and biophysical assays suggest that WcbI functions as an acetyltransferase enzyme but it requires another functional module to carry out this function. WcbI adopts a predominantly helical fold where the N-terminal 100 amino acids form a ligand-binding domain and binds tightly to coenzyme A and its derivative acetyl-CoA.	2.16575e-55
NZ_CP042862.1\|WP_010149248.1\|145141_146413_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	4.99344e-31

>NZ_CP042862.1|WP_141567767.1|143975_144908_+|hypothetical-protein
MSPVTTRTEALAGGVTISRLRHLLARGSWQRVFDGVFVTHGGPLTYRERLEAATRARGPGAVVSLECALHLWGLTDRQPPVITLAEPAGTHRTRALPGVRARRRRRLTTARRYGIPVTALPQTLLDVAAMMDADAIIARLTRAVAGRRVTVGQLREELAHHPRHPRRLLLEQVLTAADEGLESVAEVRYARDVERAHGLPRMQRQAALDGGERGRSRRLDFRDAERGLGVEIDGEIFHRDRAHLDRGRDREAAGRGDIILRAGWFEVVERPCQLAADVAAALLARGWTGSPTPCSPACAVRRDPRLRKAG
>NZ_CP042862.1|WP_010149251.1|141921_143760_+|glycoside-hydrolase-family-3-protein
MSEIGFSTGPDGVRYRDLNRNGVLDPFEDPRRPAAERVDDLLGRLHLDEKIGLLFHTVIESGPGGSVLDGPGAISKTGTRHVVVDKRVNHFNVHQLGSAGEAARWHNAVQRVAEQTPHGIPVTISTDPRHGFSENAGASFSAGSFSQWPEPLGIGALRDVELCREYAEAVRSEYVAVGIRAALHPTLDLATEPRWARQLHTFGQDPQVVTELGLAFLEGLQRGPLGPGSVACTAKHFPGGGPQADGEDAHFPYGKEQVYPGGRFADHLAPFLPAIEADVAAMMPYYGIPIGLELDGEDVPEVGFGFNRRIVTGLLRDELGYDGVVLTDWELVNDNHVGDQVLPARAWGVEHLDAAGRMELLLEAGCDQFGGEECVEVLAELVASGRVTEERIDVSARRLLLVKMQLGLFDDPFVDEDLADRRVGVESVVASGLAAQAASVTVLADDGGLLPLAGGRRRVYVEGLSAADAAPLGEVVERPEDADLAVIRLAAPHEPRSDLFLEAWFHQGSLDFPPGLPVRLARIREHCPVVVDVTLDRPAVLGPVLEAVDAVVASYGSGGPALVRALQGEARGRLPFDLPRSMEQVRTHHPDQPGLGDPLLPCGHGIPLGARV
>NZ_CP042862.1|WP_010149252.1|140368_141925_+|DUF3131-domain-containing-protein
MHPFDARHTPLARRTVLAGGLAGGLALGLPTGALAAPRGPGRPGPAPVGTDADTLWRWTRDTWASMVAMTPEDTGLVSDNITGDLATAGVYTSPTNIGGYLWSAVVARDLGIITPGEATRRIRRTLRTLQGMEHHTASGMYFNWYDPRDGSVIYDWPESGDPVVPFVSSVDASWLGAALLVVRNADRANARLAGQLFDRMRFDVFADPTFSKPYLNYGGFYLEEPTRLTAPPRTEARDLIGAGEPVWYTADHHYDTIVSETRITTYLGIIKGQVPPEAYFQAWRTFPPEWTWPEMPPVGQWRTYLGVDVFEGAHDYLGHRTVPGWGGSMFEELMPNVFVPEETWAPDAWGRNHPNHVAVQRAHGLEEYDYWGFSPASHPAGGYAEWGVDALGLNPEGYFSDVERTDRVHGQPEPDYGQGVVTPHAAFLAMMHAPAQSYDNLVAIEADFASYGPGGFYDAVNTSTGQVATRYLSLDQAMILGALGNVLGGGLLQRYFSTGEVERTLRPVLAMEEFGASA
>NZ_CP042862.1|WP_010149253.1|139515_140343_+|carbohydrate-ABC-transporter-permease
MTSVGMRSRWWLYLVLTVALLVVITPFIWMVLGSFKTNAELRQIPPTWWPQNPTLDNFRQLFSRLSFGTYFTNSTIVAVVVTAGNLLFCSMVGYALAMLRFRGKKFVFALILGTLMIPGVVTFVPLFVLVANLGLVDTLPGLFLPFLVGPFGVFLMRQFVLGLPKDLVEAARIDGAGEFRIFFQVILPLLTPALATLGILTFLGSWNNFLWPLVVAQTNDTYTLPVALALYSTGQNEQQYGLLMAGATIVVLPVLAVFLIFQRRFIQGIATTGIK
>NZ_CP042862.1|WP_010149254.1|138552_139512_+|sugar-ABC-transporter-permease
MSLVTGSRRRDPQGTRDATRSRSSRAPGAAREERAGWLLTLPFLLLFAVFTAWPVIQSVFFSVTDITNRDLRTPFQVNFVAVEQYAKAFGDPVFRQAALNTAYFVLIGVPLTMTVALAAAVALNTGITRFRAVYRLGFYTPVITSIVAVAVVWRFLLHPDSGLVNTVLSWVGIDGPNWLGSTTWAMPSLIAMATWRNFGTAMIIFLAGLQSVPQQLHEAAAIDGANAWQRFRNVTVPILRPTILFVSVTTAIGYLQFFEEPFVMTQGGPLNSTISASMYTYQQFSYGNYGYAAALSYLIFLVIAIVTAVQFRFLSDKED
>NZ_CP042862.1|WP_010149255.1|137253_138546_+|extracellular-solute-binding-protein
MRRSTLLVALTTTTALALTGCGRDDGGSAGEAAPQTGEAVSTEGLSGELDVWAMGAEGEALPDLVAGFEEAYPEVTVNVTPVPWDSAHDKFVNSISAGTTPDVAMIGTTWMGEFAGMDALDPTPGSIDTTKFFEGAQGTTEVEGTSYGVPWYVETRMVYYRSDIAAAAGFEEVPTDQAGFKEMAAALQEQDGVDWGISLQPGQTGSWQTVVPFAWSGGAEIATEDAYTLDTPETVAAVDYFGSFFTDEIADANPPEGQTEATFTDGSVPMFISGPWMMSIVEDFAAEAGEDSFGEMYDVAPVPAADGGESSSFIGGSNLGVFADTENRDAAWALVDWLTQPETQVEWYDMTSALPSVQSAWEDPALTEDAKLAKFGEELTTAQAPPSFPTWEQVAAAFDAEMEKVAKQGLSGEEALQAAQQQADSIGTGQ
>NZ_CP042862.1|WP_010149256.1|136169_137177_+|LacI-family-DNA-binding-transcriptional-regulator
MVQGTGRRPTIYSVADRAGVSIATVSRVLRRPGEVRAATRDKVLAVVDELGYVPDGAARSLAVKSHEAHGLVLPELGGPYYADLLTGYEQGAAEGGASVVVLLTEGKDDVDLLVRRLAGRVDGMVLMGAVPVSPGTVAAVRAKLPVLGLANSHEESVESFSTENLRSAQALTTHLIEVHGRRALRFVGSPEFADDVQERYAGFVAAHEAAGLAAAEPVPATFREDGGPRVVSLLVDGGPEADGVVCANDELALSVMRGLLAAGVRVPEQMSVTGWDDVMAARYVTPGLTTVSQPVRELGREVAVRMRALLEDRDSAPEQHVLPTRPVIRQSCGCS
>NZ_CP042862.1|WP_141567768.1|134964_135969_-|hypothetical-protein
MSGATLGVGTSLSTIGGDITTQVEKVDQWLSAAAPDARRRTSTLAETLSMLAGAAKDHAIHYVDHEKPIQELREAGYWLPDFGNLLPDEDRTVTENIEQIARSDEFGALPLGVGQGLLDRYRNFRLYVPKVDTVTAAGALDELTSLLGSADDVHEGTNLVRRPSGILVPQGSSADPRLPRISTLTDEATYRPGPNVTTSPDLGRPPTWARTGGRLLGGAGVALTVWDSAASQWEHDQQYHPEYSTGQRVASAGYNVATEGGGAIAGGLVGAHYGAIAGSFIPIPVVGTVGGALIGGAIGAFIGSKAGKAAGTAIKEAGSAIADGAKEVWGSLFG
>NZ_CP042862.1|WP_010149258.1|134623_134968_-|hypothetical-protein
MTSPDSALVFSPILLALGLAMIVVGLIAWSGRIRAIMLRSWPSRTLHLAPLYLGIALVLTTLSPLVGPVVGMVMLVVALVSFALGVLAVWWLPRPLTPRWLRDAPSWKDPHEHS
>NZ_CP042862.1|WP_010149260.1|134166_134637_-|hypothetical-protein
MSTPDLIVELDPPPGWGPIEQEPDDEGTVLLALAPTDWAADLGVRPNLVIGLGPESEESIGALATQTAATLIALEQGHRLVSWDLWRDEGGRRLLSTWPSGDALICTTTWMRVEECRPLSVTATVDADRYLRVMPLIGAAVDGLRVRPTREEDGRG
>NZ_CP042862.1|WP_010149248.1|145141_146413_-|FAD-dependent-oxidoreductase
MSQSVEVVVVGAGLAGLTCARTLQDHGVGVRVLEAADAVGGRIRTDEVDGFLLDRGFQLLNPAYPMVRSDVDLDALALQPFRAGLACRSDRSDSLLVMADPRREPQLIGQTMRSGKLHPAALGSLARWAAPALRADWALHGDREDVSRRESMDRANFHGPLRRVVDTFLAGVLLEDDGSTSTAFTHLLTRMFATGRPGLPERGMQALPEQLAETLHTPVELGTEVVSVSGGRVRTAGGEDIGADLVVVATGAEAATALTGRPSAGGKGVTTHWYAVEQAPTDLSLLVIDQREKAGPVINTAVMSNAAPSYAPAGRHLVQASSLLRPGQEPVADDVVATQLAGIYGVPTDGWQLLRRDDIRYALPAQPAPLHDREALEVEPGLILAGDHVDTGSIQGAIVSGRRAAEGFLRRRGDRAAPLAAEA
>NZ_CP042862.1|WP_010149247.1|146703_147837_+|glycosyltransferase
MVPEPVSGVRVRHVPAAHPYVEHVHALPSTASAPAVAVLPDPPVPGAPPGQWWPHPALEEAWVREHAHEQDVLHVHFGVEGRSLPELRAWLDALADLGLPLVHTVHDVDHPHLHDQRHHREQLALLVERADGLLTLSEGAAQRVEREHGRRPLVLPHPHVVPMDLLDRPRPVHEELRIGMHLKSLRTNVTPMRVLPALLEAVPHLAARTGRPAVLEIRAHPEVLDPDFTRHDEALARLLRRLLDDPPPGVEVLVGPRLDNVQLWAALQAVDVSVLPYAWATHSGWVEACRDLGTWVLSPDVGHLEEQGAGMVIAWGPPHQAPLPSRLVDLLALCAAGPPARPGAQARAAQRAELARRHAQVYAGVIDGRRIDGGSPP
>NZ_CP042862.1|WP_010149246.1|147833_148745_+|hypothetical-protein
MSEDGRRRHYGGFYGLEELPATGRPRLAVFGNCQAEALRVALDTAGVLDSVRMPPVHELDEADLPHLDRLLAWVDVLVAQSVADDYRGMPLGTSQVATRLRPQARVVRAPNYFFSGLYPEQVLVRHPEIEDPPVVPYHDVRRLGRAAGWDGPWEAPAELVREVAAASLAELERRERAQQSLRISDVVRASGAGAGRTVDHPGNEVLLALARRVLEGVRPGSGEAVQDPGRVLLASVATPLSRSVLEALDLPGEPREGWLVDGEALSDDEVGAAHQEFYARHPRVVEVGMEKREDLLRRWGWRA
>NZ_CP042862.1|WP_051125247.1|148741_151036_+|glycosyltransferase
MTLPLVHLVPGPVEHGVVRHALGVHPHLGEAELLRCDRLDELPDDAVAGRVVVAQVTDRLLASSPAQGMQVWHRVLRGAARVLVVLHDLPQRSDGRHRRARSQLYASLAASADTVVVASAHERLLLAAALRWARPDAARAVLGRTVVAPLPVEPDTDAAPRPPSPVTRSQALTIVTLGFVYPGKGLEEVVDAAALAAQDPRLEGRTIEVVNLGGASQGHEDLLEELAVRARDRGVRWHSTGYVPDERLPGLLATATVPVAAHRHVSASGSVATWLAAGRRPLLLDSRYARELDARLPGAVQPVSADRLAPALADALVRACSAEGTDPTWLPPDVRLGPTWGEAGRLVSELAREPAVSVVVPYYRDQEMLDLLVDRLGAQRGVLGGLELVVADDGSPRPPRLPAAPHGALGRIRVLRQPDEGFRLAAARNLGLRVTTGRVVILLDGDTVPEDGYVAALQQACRVRPTLAVGRRRHADLRGEGRWPPTTELPAPAWLAEGYAQTQDLQVADDTSFRFVIGAVLGVSRAVLDTVGGFEGDLTGYGGEDWEFAWRCWLAGAAMQHVPDAVAWHDGPDVAGRVDGTAAGLSGVKNAETARLARLLPHPLVRGRGWTYPQPDVVVRLDVRGWTHGQVVLAVESVLRQGDVGVWLTGADETAEHAVHDPRVHLGRPPAEVVARARAEVLLQRPVWVRRLPWGPWPAHVDAPELCCETWTDDSASGVQAQVTRSSGLTRLQGAPPGPCWLSAEAVEPIPSGVVVEHWRAAHP
>NZ_CP042862.1|WP_010149244.1|151074_152439_-|amidase
MPRDAAALAAGYAEGSLSPVDVVAEIQQVIEAREPELNALAVRDDVEDTLRQAQAAAQRWATGRPLGPLDGVPVTLKENLARAGVLMTAGCAGATPVVPDVDSPVARRCREAGLIVLGSTVMPDWGMLSSGVSSQHGITRSPLDPTWTTGGSSSGAGAAAAGGYGPLHVGTDIGGSIRLPGTWLGLATLKPSAGRIPLHAPYLGRAAGPMARTARDCALLMAVLSGPDPVDWTSLPREEIDWSDARPHVRGLRVALWTEAGYGVEADPEVVAAVEAAAGRLADAGAQVEPVRPWLTQDLLEGVNRFWQARSWADFSRLTPDAQGRVLPFIADWVSGARDLTGTEVMDAYHCFAEVQARTCAAWAAAGDPDLLLSPVAPGVAFPAEQPMPYPDDGRGMWHINYTMPWNMTGQPAGTAAVGLTVEGKPLGVQVVGRSFDDLGVLRGMSALHQPPLG
>NZ_CP042862.1|WP_010149243.1|152700_153471_+|CHRD-domain-containing-protein
MKISRKFLAAPAAGAAVLLMAAGPALAAGHTEGMADLQPVPVNDAPGSGSAMITLDGTTLDFTLAYQGLLADAPHAAHIHYAGDAANMCPTAEDDADGDGFLTTTEGAPSYGGIKVSLTTEGDTTPDSGLAVDRFGVGDDVSYSRGGVEVDQETADALADGEAVVVVHGVDHDGSGAYDEGERGASDLDPSLPGEATDPALCGVVEVSQMDEMPGGGVETGAATDGGQNIALAAAGGAALVGGALVLARRRTAEQS
>NZ_CP042862.1|WP_147899704.1|153486_154266_+|class-F-sortase
MKTGDVGQRGTHRAARRHRPLLPTLAAIGLMLGGGTAVAVGVAGPEPARPPSLADVPRASTSGDDTASPRTLPMPATVDTDVPAVQDSREPAVQDSGLDRQDPEEPEQAPPVGEPVSVSIPAIGVTSELLHLGLDDQGALEVPEGEDYDSAAWYDGSPRPGEPGPAVVLGHVSGAAGPSVFFDLALLQVGDTVEVDRADGTTATFEIYDLQQFPKDAFPTLAVYGNTPGPELRLITCAGTFDDDTGHYDDNIIVYAREA
>NZ_CP042862.1|WP_010145997.1|154269_155934_+|CopD-family-protein
MSRSTLEGTTPPRAHDPDGHAARTVGEVENTSRGSARVVDEGDAAPTEPPVRPARAPLTGPAFPRRRVGAVAGALLVGVLVLALVVGGGAPSPAPAGLPDAGPVTGWGLPVAELSTRVLAVLTIGQLLFAAVLAPSRGAAPSAGALRALHATTWTAAGWVVAEVVALVLTASTIYGVPVGRLSTQSVLGVLTELPAGRSALWVGLLLVVVTVGSALLTRRPTALRAAAGLLLVAALGAVTIPGVLAGHSAAAGNHVPAVVALSVHVVTASLWVGGLAALLMYGRGRVESVHAVRRFSAVALTCLALLLISGVIAALLVAGVPSWSWLGEGWAQLLAVKTVLLTALGLIGWQHRRATLPALEAGRPWTFVRLGVVEVALMALTITVSVALGASAAPSPQSSGTTTSSVGAAADAGGEQETPEDGPSSAAEERGGEADEPDAGDEPLVEDMSGHDHGDLSVAILIDDERFHVAATVRPGQVVTVYNSSDDAATITALGADDAAGEARGDADFDVEVPARTFITFSAPEAEGDYAFVSSPDAEPVDGFADTLVVRAP
>NZ_CP042862.1|WP_010145996.1|155968_156820_-|formamidopyrimidine-DNA-glycosylase
MAEGHAVHGMAARVRQLVGQTGRSSGPVTEVFDPAVVDGSAVAGAEAHGKHLLVHLGESRWSGHFHLGMHGRVSVRRHRRALGEDGLPRTDPPVPEGLAWRFLTGAFLLEVTRPTVCELLDAEGLAALHARLGPDPLRDDADPEVAVSRLHRSRRALGVLLLDQGVVSGIGNVYRAELLWRARIDPHSPGRAVPPEALQTLWQDAIDLMTVGLGAGWIVTDPGQLTDARDLLTRGEPVPRWPKRYAVYLRRGRPCPRCGETVRAERMGLQTAYWCPGCQVLHS
>NZ_CP042862.1|WP_010145995.1|156857_157652_-|3-oxoacyl-ACP-reductase
MSSTIDLTQRLAGRVAVVTGGASGIGLASARRLAAEGARVVLADICGEEVGGPLAQELGGLFVQTDVTDAEQVQRLFATAKETYGSVDIAFNNAGISPPEDDSILTTGLEAWRRVQEVNLTSVYLCCKAALPHMVEQGRGSIINTASFVAVMGAATSQISYSASKGGVLSMTRELGVQFARQGIRVNALCPGPVNTPLLQELFASDPERAQRRLVHVPMGRFGEPEEMAAAVAFLASDDSSFMTASEFLVDGGISSAYVTPLAD

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Crispr_ID: NZ_CP042862_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_2

311403-311486

Orphan

Consensus_repeat	Method
CCGACTCCTACGGGACGCTGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042862_2

>merge|NZ_CP042862|2|311403-311486|CRISPRCasFinder
CCGACTCCTACGGGACGCTGCGGGGTTGCTGCCGATGGTCCCGTAGGAGTTGGCAGATATCCCGACTCCCACGGGACGCTGCGG

>NZ_CP042862|2|2|311403-311486|CRISPRCasFinder
CCGACTCCTACGGGACGCTGCGG	GGTTGCTGCCGATGGTCCCGTAGGAGTTGGCAGATATC
CCGACTCCCACGGGACGCTGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_010149340.1\|300165_303765_-\|FtsX-family-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|225669
NZ_CP042862.1\|WP_051125251.1\|313665_314112_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239217
NZ_CP042862.1\|WP_029541927.1\|306247_306760_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274418
NZ_CP042862.1\|WP_010149319.1\|320937_322548_-\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817
NZ_CP042862.1\|WP_141567777.1\|306786_307191_-\|hydroxyphenylacetyl-CoA-thioesterase-PaaI	unknown	unknown	gnl\|CDD\|131339
NZ_CP042862.1\|WP_010149334.1\|307279_308599_-\|NAD(P)-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|236211
NZ_CP042862.1\|WP_010149330.1\|311554_313255_+\|phenylacetic-acid-degradation-protein-PaaN	unknown	unknown	gnl\|CDD\|143445
NZ_CP042862.1\|WP_010149320.1\|320276_320579_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|224278
NZ_CP042862.1\|WP_010149324.1\|316041_317142_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|223584
NZ_CP042862.1\|WP_010149326.1\|315190_315907_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP042862.1\|WP_029541925.1\|308719_309319_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_158640847.1\|319521_319905_-\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP042862.1\|WP_010149327.1\|314146_315175_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP042862.1\|WP_010149338.1\|304858_306175_-\|phenylacetate--CoA-ligase	unknown	unknown	gnl\|CDD\|131210
NZ_CP042862.1\|WP_010149339.1\|303968_304754_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_081480650.1\|317165_318389_+\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP042862.1\|WP_010149322.1\|318479_319532_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP042862.1\|WP_010149331.1\|310494_311376_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_029541924.1\|309379_310177_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133382
NZ_CP042862.1\|WP_010149341.1\|297379_300169_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|225669

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_010149340.1\|300165_303765_-\|FtsX-family-ABC-transporter-permease	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	7.07569e-05
NZ_CP042862.1\|WP_051125251.1\|313665_314112_+\|NUDIX-hydrolase	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	3.65923e-17
NZ_CP042862.1\|WP_010149319.1\|320937_322548_-\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	1.06812e-45
NZ_CP042862.1\|WP_141567777.1\|306786_307191_-\|hydroxyphenylacetyl-CoA-thioesterase-PaaI	gnl\|CDD\|131339	TIGR02286, Acyl-coenzyme_A_thioesterase_PaaI, phenylacetic acid degradation protein PaaD. This member of the domain family TIGR00369 (which is, in turn, a member of the pfam03061 thioesterase superfamily) is nearly always found adjacent to other genes of the phenylacetic acid degradation pathway. Its function is currently unknown, but a role as a thioesterase is not inconsistent with the proposed overall pathway. Sequences scoring between trusted and noise include those from archaea and other species not known to catabolize phenylacetic acid and which are not adjacent to other genes potentially involved with such a pathway.	1.42254e-36
NZ_CP042862.1\|WP_010149330.1\|311554_313255_+\|phenylacetic-acid-degradation-protein-PaaN	gnl\|CDD\|143445	cd07127, ALDH_PAD-PaaZ, Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like. Phenylacetic acid degradation (PAD) proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida) are putative aromatic ring cleavage enzymes of the aerobic PA catabolic pathway. PaaZ mutants were defective for growth with PA as a sole carbon source due to interruption of the putative ring opening system. This CD is limited to bacterial monofunctional enzymes.	0
NZ_CP042862.1\|WP_010149320.1\|320276_320579_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	2.38231e-14
NZ_CP042862.1\|WP_010149322.1\|318479_319532_+\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	5.98232e-24
NZ_CP042862.1\|WP_010149324.1\|316041_317142_+\|phosphotransferase	gnl\|CDD\|223584	COG0510, ycfN, Thiamine kinase and related kinases [Coenzyme transport and metabolism].	5.81789e-10
NZ_CP042862.1\|WP_010149326.1\|315190_315907_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	1.54414e-143
NZ_CP042862.1\|WP_158640847.1\|319521_319905_-\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	4.71867e-16
NZ_CP042862.1\|WP_010149327.1\|314146_315175_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.23152e-26
NZ_CP042862.1\|WP_010149338.1\|304858_306175_-\|phenylacetate--CoA-ligase	gnl\|CDD\|131210	TIGR02155, Phenylacetate-coenzyme_A_ligase, phenylacetate-CoA ligase. Phenylacetate-CoA ligase (PA-CoA ligase) catalyzes the first step in aromatic catabolism of phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Often located in a conserved gene cluster with enzymes involved in phenylacetic acid activation (paaG/H/I/J), phenylacetate-CoA ligase has been found among the proteobacteria as well as in gram positive prokaryotes. In the B-subclass proteobacterium Azoarcus evansii, phenylacetate-CoA ligase has been shown to be induced under aerobic and anaerobic growth conditions. It remains unclear however, whether this induction is due to the same enzyme or to another isoenzyme restricted to specific anaerobic growth conditions. [Energy metabolism, Other].	0
NZ_CP042862.1\|WP_010149334.1\|307279_308599_-\|NAD(P)-binding-domain-containing-protein	gnl\|CDD\|236211	PRK08268, PRK08268, 3-hydroxy-acyl-CoA dehydrogenase; Validated.	2.28269e-136
NZ_CP042862.1\|WP_081480650.1\|317165_318389_+\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	7.74099e-83
NZ_CP042862.1\|WP_010149341.1\|297379_300169_-\|FtsX-like-permease-family-protein	gnl\|CDD\|225669	COG3127, COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	2.29646e-08
NZ_CP042862.1\|WP_029541924.1\|309379_310177_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	8.22479e-36
NZ_CP042862.1\|WP_029541927.1\|306247_306760_-\|hypothetical-protein	gnl\|CDD\|274418	TIGR03074, PQQ_membr_DH, membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family. This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.	0.00574425

>NZ_CP042862.1|WP_010149331.1|310494_311376_+|hypothetical-protein
MARRHGGVANRADLLRAGLADHDVRAEVDRGVWHRAGCHTLCIEGAAPQGEGLLWRALWESGPRAVLDGPTSLIAAGLLHWEEPLVHVCVPRNATVRDIPGVRCHVVRDIGPTIPFGLRRTRPEVALIRAAEWARSDRAASTLIAMTVQQRLVPPAAVLDRWSQTRRSSRRRLLDSVIRDVCDGAHSINELDVAQACRARGIPEPTRQQVRRTSTGTVYLDLFWEGFGVHAEVQGAHHLWGLNGVDDAVRGNALAVGARGLVSLQIPVLGWRLHPEVFLDQIADALRAGGWAA
>NZ_CP042862.1|WP_029541924.1|309379_310177_+|MerR-family-transcriptional-regulator
MLSIGEFARLAGVSVRMLRHYDQLALLRPQRVDPHSGYRSYAAAQLARANQLVGLKELGFTLEQVGVLLDGELSEGEVIALMRARRDALREQLAADRHRLAALEARLRSIEKENPMSDYIEKPLPALTLAQLTVRIEEMSEVEEEMSSMFQRVNALIGDRPRLGPGVATYAPDGDGMIAAAAEQVGPDETPDGLEAGRLAAVDKALTVRYAGADLSGIQQAWQGLVAEVEARGLTPTGTCREVYDVTPFDGAGAGWSVDLQQPVA
>NZ_CP042862.1|WP_029541925.1|308719_309319_+|hypothetical-protein
MGLNMGLVYVRGAEVGDLAAIGLVPTGERMSADVASTSPDGELVVARPVGGWLLLVGPELLLGFEDEMIARTLDRQVVAAMLGSTSDTFSFARCDPDGTRRHVVDSYGERAVDEGPPLPEEAGIERLTEDTIQGLAVEVTGVNFWDSFMEEDWQVLSMGGQGQDGGGDIAQSRPSSPTQPVEPTQPQPRKGFLARLFGR
>NZ_CP042862.1|WP_010149334.1|307279_308599_-|NAD(P)-binding-domain-containing-protein
MGAVIDADAPGPQSASSPTTEGTDGPADSPSPHPLLRAPGEVRVAVIGAGAMGAGIAQVAAQAGHPVVLVDAQPDAADKALATLRQTFDKLVAKGKVSEADAKATLGRVTPHTTRDMSTVPPVALVIEAVVEHLDVKRVIFRQLESSQPSSTVLATNTSSLSIDDIAGEATSGHDAALHGGTSPAMAHPGRVIGLHFFNPPPLMALVEVITGDDSDPAVLDVAAELMRRWGKEPVRCTSTPGFIVNRVARPFYGEAQRMVEEGLVDPATVDLALREAGFRMGPFELTDLIGQDVNLAVGESVWRQTGEDPRYAPTDFQRDLVREGRLGRKTGRGVFEYADGRPVDAEPDEALAGKLVGGPLQTDPVARTLAMLVNEGVDLVHRGEATAGDVDTAMRRGTNYPKGPHEWLAEIGAETVRAQLTELDRLYPGGRYRASEAL
>NZ_CP042862.1|WP_141567777.1|306786_307191_-|hydroxyphenylacetyl-CoA-thioesterase-PaaI
MWEQDKASATLGIELLDVGVDHHDDGDLGHAHTRMTITDTMVNGHDIAHGGYIFTLADSTFALACNATGRTTVAASCDITYLLPSRLGDVLVATARERLISGRSGITDVTVCRATDNAVVAEFRGHSRALRPNP
>NZ_CP042862.1|WP_029541927.1|306247_306760_-|hypothetical-protein
MPLGQGRREALRRRYLSLGLGELTAAGVFSLIAWSTLTPRWSSREATTLWWALGPLVLVLVQAGAYWLLGRSWVGRGRMPRSVAGAYRAFRVLDPLLLAVGLVMILVRGGEGPGPLVLTLCVWAFAALEFVNYYVVRLAYPLTSWTREVGRWRSPRLLQDVRQAEQTGRP
>NZ_CP042862.1|WP_010149338.1|304858_306175_-|phenylacetate--CoA-ligase
MATLPDIGPRPDLHDEAETWSVDQLRAAQLQRLQTCVRRAYDGVDHYRRQLDELGVHPDDITSLDDIRLLPFTTKADLRANYPFGMFAVPREQCVRVHASSGTTGRPTVVGYTQGDISTWADLVARSLRAAGTRPGDLVHVAYGYGLFTGGLGAHYGAERLGCTVVPMSGGQTEKQLQLIEDFGPRVIMVTPSYFLSLMDAMVERGVDPAGTSLQIGVFGAEPWTEAMRAEIEQRCAMHATDIFGLSEMMGPGVAQECVETKDGLTLWEDHFYPEIIDPITEEPVADGEEGELVLTAMTREAMPVLRYRTRDLTRLLPGTARPGMRRLAKITGRSDDLMIVRGVNVFPTQIEELVLGIPGLTPHFQCVLTRPGRMDQLTINVEGEPGLSGEDRERLAIRLAGQVKDRIGTSAQVVVLGEGGVERSVGKARRIVDQRDD
>NZ_CP042862.1|WP_010149339.1|303968_304754_-|hypothetical-protein
MTTQPHLPYTTRSTSSGLDIDYLSMNDEADGMVVLMSNALVPGREDRRFPAFHRWSWASSWAGSHVLSVADPGLRDNPVPDGAWYLDAQHDTIHAIAETVAAEAEQRGIPLDRVVYYGSSLGGFGALCAAAVTHSHAVVEVPQIDFQRWFPGAIKKVEEHVIHGSIAQLRAAHPERVDVWERFRHEGHIPSFTILTNEHDKSFEDQLGLISSVRDHALYRKTRAELVITAATTGHQVLPKEFATRVVQEALHWSRPVDAPG
>NZ_CP042862.1|WP_010149340.1|300165_303765_-|FtsX-family-ABC-transporter-permease
MTWGSFARARARSSWGLLLTLLALVTVTSAIIAGTVGYSQAAASTAARAALTQGEPTETGVQVQTRLAEEPQEQDTRARATITDAFAPAPVSIGRLVVSEPRPVSAAGSELDGDLVVMGGPDLAVGQTPDELVTLLDGAWPQTGGDGSTDAPAQGALHVGAAQAWGVEVGDVLVVADRAVQVSATWQPLRADDAFWFGDELTRTGVADEEATRGPLVVDEELAQQVGSPFVRWPVRPESAQIQPDDLAVLAAGAENLRFDLREAEGVAVRGIQVEGDLAPTAAQASTNLATARALGVIPLSVLVLVTGLAVVQLARLLAATRAPQAQLLVARGASRQQVLLTGLLESVVVAAVGTVLGAGLAWAVMQAVPGGEELLGRLVLTALTTLVGISLALAVIAALQARRLSGGEAVADRSGRARAATTIAVVVVVLAAAALSWWQLRRAGSPLTRAEDGTLGTDLVAGAAPALLLAASAVAAMALLGPLTRLLEVATRPSRTATHHLASAQVSRHLQVYAVPVVLVVLAAGSTTLAALYSGTSAQLRDDLAAVSEGAELRADLVRPPAPRSASTLADPPPDLTELPEVSSAALVWVEDSARIGDVPVPLTLADTQALAAVANVPDGIPAGVVPSGLEELIATDGEQQQRTPIAVPPGAQELELTLSTERTADRWEIARLDDIVRVEEQLDEIAAEQGTDIPEGETEVPEAPPLAERVTQRLDGVVEAAAAPVPLRVSLLVEDVATGLSATVTSEFVQAPGPTLDYDPETLSDFTASPGTTQESVTFTLPAGREHTVEAVTVEVAADQPGQEQMFYEGSTSLGVDLRLRAGGEPILADGGWGSTGALSAEQVAPLVAAAEAVEDATYRTTVEPDQGFVGDEGTALISSVETNEERIPTWYDTSAATWRVQWPEVRSGLAAEVVLAPGAEFSGAAVAGSLDGGPPEETPASGSVPVAITTEVASAAALAPGDPLTLSVAGGRLPAEVSAVVDALPGQRGTVAALADVRVVASLLAEQQRSLPWPDQVWADASGDPAAAVSALAQRQDLRAVTGPGSVSVTDATSAARLVFWVASAGAVLLALTGVAAVAATLLSARRPEVAVLRALGMPPAAQARSRALELGGVVLLAVVFGLAAGWVVGTAVVPELATSTTAPGRLRLPAALRLESTPWAVLLGTTLVGLLALLAVLARRVRAQALDRDYREEIR
>NZ_CP042862.1|WP_010149341.1|297379_300169_-|FtsX-like-permease-family-protein
MTPRHGIPPSTGAGRLARRQFATDPWVSVGLAVLVGVVALLLTAAPRGLIDVQGRQLTEEITALSAAQRDLRGDWQRTVIYGSAEDLTGDPSADGWAPLREGAERVRTQQPEPLRDVLGSPQFLARLESDVPFDPEVETGYYTATLSLAVDPDLRGHVELVDGDWPELVVGETPTLRGREDRQDTPEQPEEDAPVPIVVLAETAQELQLGVGDPLPGTDLVLSGTYVPRDPDDPRWQHVDNGAVMGTLYDPNLGAEALLTGFLSPDNRGAVGPPASVRMRVWYPVDPTAVTGTTGQVEALTGQVNGFLAEQHTFASAEEILDAGSPQIPLFTTELTQALERIASQQRATSSLLAVIAAGPLGVALAVAALGARLVVHRRRSAIALALARGAAPSQLRRLIAVEGLLLGVPAALVGHAAAMLLVPGPTPWWQWLVTVLVAVIPSLALATSLDDASLLQQRQDLAGRSRSRWRWVVEVVVVGLAGVATWRLLGREARGDDAGATGIDVLAAATPVLLALAACVITLRLYPLPLAALTAALRGRPGLTPFLGAARALRDPAGGLVPTLAVVLGTAVALISAVLLSTVTRGAQIAAWEDNGAPVRLNGPVLTEELREEIRGVEGVTAVGGVADSGSTASLVVDGERTPVRIWVVEPEVRQVYASSELIPGPPPEFYESDGIPGVITLRGADEAVPEDPEAVTVSGLGDVEVLGHLDQLSGIRVTGPGVLVDGDRWVEAGGTMPRATTTLIGVADGADPEEVAAGVGQIIGTGGVVTTVTSRLEAFTEAPVTVGLRQLFVGATVVSALLTVLAVVVVQLMGSGARSRLLATLRTLGLAPGQTRALTAWELAPLLVTSVAVGSVLGLGVPWVLLRGLDLTGLTGGSRQPDLYLDLPLLAAVLAAVVLTVLIAVTVSAWLAGRTNLAQALRVGEER
>NZ_CP042862.1|WP_010149330.1|311554_313255_+|phenylacetic-acid-degradation-protein-PaaN
MAKTATTHPLLDQHAETIEAATQALRERSYYSRYPESPSPRVYGEGSPERGQLAHQETLNKEIDGLADQPTTGRSVSSEKSPYGPTLGVRYPELDVDAAMAAAQAAIPAWRDASAEVRAAVLTEVVERINARSHEMAHAVMHTSGQPFVMSFQAGGPHAQDRALEAIVVALEEQRRVPASVTWEKPAKGDPIRMQKDYRLVPRGVALVIGCNTFPTWNAYPGIFASLATGNPVVIKPHPRAVLPLALTVQIAREVLAEAGFDPALVQLAAEDDGGTLAKDLALHPAVKIIDYTGGPGFGRWLETEAVAAGKLVYTEKAGLNTVVVDSTDDLRGMLGNLTFSFSLYSGQMCTAPQNVYVPATVTTDEGELSAEEFAGKLGQAISAFTGDDAKAVEILGATVNDDVRSRVTDVPALAQSLGGDVVLDSRPVSHPSYPDAVVRTPALIGVDAGNETAYTTECFGPVAFVVRTADTAESLRRFVQTVAEHGGMTAAVYSTDEQVLDDARDAAADAGVALSENLTGQIFVNQTAAFSDLHGTGANPAANAAYADAAFVANRFRVITSRRHV
>NZ_CP042862.1|WP_051125251.1|313665_314112_+|NUDIX-hydrolase
MLNATLPRKRLIAQGLVRDDAGRVLLCELTYKTDWDLPGGVVDPRESPRQTVQRELWEELGLDLAVGELLTVNWLPPYKQWDDALLLVHDLGVQPGLADRVTLQASELRAVHWVDPADIDQHVAPYVARHLRSLLDDGPGELEDGHRI
>NZ_CP042862.1|WP_010149327.1|314146_315175_+|alpha/beta-hydrolase
MTHDARPVQTARTTTAVREAGEPTSPTLLLIHGNVSSSAFFDRLIENLASEFHVLAPDFRGYGDSARETINATRGVADLSNDIAALLDALEVEGAVDVLGWSAGGNVALQLAMDHPHRVRRLVLEAPGSPFGFGGSTGLDGRPVAEDFAGSGGGTANPAFCAALQAGDRGEEPTSPRTTLRAFYVKPGFTFAPEVEEAYLDSMLKTSVGDDVYPGDTTTSDTWPGVAPGTTGMNNALSPKYLDQSGFADLDPAPPVLWIRGAEDQIVSDTSMFDLAQLGRLGAVPGYPGEDVCPTQPMVGQTRAVLEQAGEFTEVVYEDCGHSPHLEHPERFAEDVRAFLRG
>NZ_CP042862.1|WP_010149326.1|315190_315907_-|purine-nucleoside-phosphorylase
MSTHIAADPGQIAPRVLLPGDPLRARWIAENFLDDATCYSEVRGMLGFTGTYRGERVSVQGTGMGQPSASIYVNELISEYDVQQLVRVGSCGALTERLKVRDVVIAQAAATDSSMNSLRFQGYHYPATADFALLRAAVEAAEAADAPHLVGTVFSSDSFYHSRPELTGKVVEYGVVAVEMEAAEIYTLAAQHGRQALAICTVSDHIVTGEETSAQEREQTFGDMITIALDAALATPLP
>NZ_CP042862.1|WP_010149324.1|316041_317142_+|phosphotransferase
MGHRISAALRWRLRAVRARRAAARRDPHAVALEMVRQVERRERPLPTRLVRRVFTAHGRALTAASAPESIASLIPEMLSEPAGRQHVRAAVAADAVVLAKFGVRGGIKLRAAYAGADLTVAVDGSGDLARLERILHSHRVVGAVDPTLIPPLVSSGSLPGGACYVVERWVHGRSVTTGSRLTEAAPEVLRRLRAVHLGHGVEQLPLGAWWDEMRQEWWEETVRAELVPPHVVDAVGALVGHDDRTVATSWCHGDLVASNVIDTDAGHVLIDWERAGVAPVMLDAARLHLFSGDPERTLADIRRQWSWETGPTEVDLTHQLALAHAYQLSAYPLRRAGLATHARAAVYERQARRQVARLAQVLDLPV
>NZ_CP042862.1|WP_081480650.1|317165_318389_+|PQQ-dependent-sugar-dehydrogenase
MPRPRSRSPRPLLVGALALALAGCSGGAEEAEGDDARLGEVDAEPAPAESEGAGSGGRDAGDDADDTLPALEVEVVAEGLTLPWDVQHLPDGTALVTERDGRLLALDGGEVREVALDIPDLFVGSESGLMGLALAPDGGTAYLCHATQSGGQPQDVRVTRWQLDEGATAAITDGVVVDGMPITSGRHGGCRLLLTDDALYVGTGDAADETNPQSLDSLGGKVLAVTPEGEPLADAPFVDGDPRIYTYGHRNVQGLASQPGSGTIWSVEHGSSVDDEVNRLEPGANYGWAPGAGYDESVPMTDTERFPDAVEAAWSSGDPTHATTGAVFLDGEQWGAWDGALATAELKGAGVTVLRVDGEQVVGEDRMAELEGAYGRLRSLTLADDGSLWVTTSNGEGDVVLRVTPRE
>NZ_CP042862.1|WP_010149322.1|318479_319532_+|Fic-family-protein
MHSFLDLDRVLGTVPAPVVMALRDVDRGQGSEGLYLNQVPDLLTELAHRARVASITASSALEGVVVENRHRAAAIIANRRIELRTRSEQEFAGYRAALDYLFADDWRPLNVGLLLHLHRLLFAETPGSGGRFKEGDNLVVDRSPDGVQTVRFKPVPAARTDDYVAYLIDSYAQAIRAERHHPVLVVGLFVLDLLVIHPFDDGNGRVARVLTNALLSEAGYGVGRFVSLEELIAESADEYYQALLDSTHDWHEHANDPWPWLTYFSALLARGYSRFAEGVAADRSGATKSERVRAHVLKHSGPVFAISDIRAALPGISDPTIRLVLHELKDEGLLKPQGTGRSAVWLRVTT
>NZ_CP042862.1|WP_158640847.1|319521_319905_-|VanZ-family-protein
MILTWAGLGSSGNSGINLIPGAGLRAAVANVNARVGLINLVGNVALFVPIGVLAVLAGWSTLRAIVIAAGLSALIEVVQFVVGRTADIDDVLLNALGGAMGALLAQVLVLAWQGARPGRKGASVLRW
>NZ_CP042862.1|WP_010149320.1|320276_320579_+|antibiotic-biosynthesis-monooxygenase
MTFANVGTLGALPGQRDALVEILTRRSSELDQAGCLLYEVGVSEDSPDTVFVAELWTSAEAHQASLSLENVQAAIQEARPLLSGEMGGFRFDVVGSPLRA
>NZ_CP042862.1|WP_010149319.1|320937_322548_-|glycosyltransferase-family-1-protein
MRIAILAGGSRGDYQPVIALAQELVRRGHEVGVTATTDFAPWVREHGLTVEEVHVDAMQIYRDGDVSTVMASTGVAGQVGALRAQAAAMAPELARALIDLWPRYDAIISTALTVGWVAQLAAHDPRPQAVLLFVPALPSRHGDASLFADREGASLHNLRAGLRGVLPGLAMSAPVTSALAAQGVPRRRSLRALRHTLTVPAVIAHTPQLIAPRRVSGRQIVLTGYPFLDSPAGTTLEPELEAFLGDGPPPVYAGFGSQSLRVTRAALGHAIEGALEAGHRVVALRGTGLPEGYDERVLFIDGAPHDLLLPRTAAIVHHGGAGTTAQALRSGVPQVVVPFALDQPFFARRAHEIGVAAAPVPVGATSVEALRLAVLDATQRHERAAEVGALVQQERGVEETCDRLLDGLQRERRSLGHTAPGGPPSRRDTSLTRYLHADEARVGLKVLYAGKDDDSGIEDPDLVRAGHILLHRHPGVIQLFYGPGVNHCIVEFVGLEDQFISTMVGFDHHRDGHYPGLLVPSEEEWVQACAAGWWNQ

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Crispr_ID: NZ_CP042862_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_3

840316-840443

Orphan

Consensus_repeat	Method
CCGGCCGGGGAGGATCGGTGCACG	CRISPRCasFinder

2 spacers

DEDDh

The CRISPR arrays of NZ_CP042862_3

>merge|NZ_CP042862|3|840316-840443|CRISPRCasFinder
CCGGCCGGGGAGGATCGGTGCACGCGCGCCCATCCTCACCGGGGGAGGCCCTCCGGGCGGGGAGGATCGGTGCACGTGCACGGATACTCCCCGGGATTCGGGTCGTGGGCGAGGGGGATCGCTGCGCG

>NZ_CP042862|3|3|840316-840443|CRISPRCasFinder
CCGGCCGGGGAGGATCGGTGCACG	CGCGCCCATCCTCACCGGGGGAGGCCCT
CCGGGCGGGGAGGATCGGTGCACG	TGCACGGATACTCCCCGGGATTCGGGTC
GTGGGCGAGGGGGATCGCTGCGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_010148929.1\|837937_840022_-\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319850
NZ_CP042862.1\|WP_010148927.1\|840525_841719_-\|glycine-C-acetyltransferase	unknown	unknown	gnl\|CDD\|235893
NZ_CP042862.1\|WP_010149059.1\|832039_832321_-\|Rho-termination-factor-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|236490
NZ_CP042862.1\|WP_158640853.1\|845687_846632_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238141
NZ_CP042862.1\|WP_010148931.1\|837639_837918_+\|DUF3618-domain-containing-protein	unknown	unknown	gnl\|CDD\|378834
NZ_CP042862.1\|WP_010148925.1\|842842_843889_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|235825
NZ_CP042862.1\|WP_051125237.1\|831292_832012_+\|membrane-protein	unknown	unknown	gnl\|CDD\|225239
NZ_CP042862.1\|WP_010148932.1\|837073_837550_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
NZ_CP042862.1\|WP_010148923.1\|845448_845622_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_147899738.1\|833279_834074_+\|ribonuclease-PH	unknown	unknown	gnl\|CDD\|178914
NZ_CP042862.1\|WP_010148933.1\|835966_836926_+\|homoserine-kinase	unknown	unknown	gnl\|CDD\|234920
NZ_CP042862.1\|WP_010148928.1\|840089_840272_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_010148917.1\|850935_852078_+\|bifunctional-chorismate-mutase/prephenate-dehydrogenase	unknown	unknown	gnl\|CDD\|183035
NZ_CP042862.1\|WP_010148934.1\|834866_835967_+\|threonine-synthase	unknown	unknown	gnl\|CDD\|236013
NZ_CP042862.1\|WP_010148926.1\|841728_842781_-\|L-threonine-3-dehydrogenase	unknown	unknown	gnl\|CDD\|180054
NZ_CP042862.1\|WP_141567737.1\|834070_834754_+\|non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl\|CDD\|234648
NZ_CP042862.1\|WP_010148918.1\|849556_850795_+\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP042862.1\|WP_010148924.1\|844117_845233_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NZ_CP042862.1\|WP_010148920.1\|846848_848411_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|379207
NZ_CP042862.1\|WP_051125230.1\|848895_849558_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_010148929.1\|837937_840022_-\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319850	cd07552, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase. Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP042862.1\|WP_158640853.1\|845687_846632_-\|hypothetical-protein	gnl\|CDD\|238141	cd00229, SGNH_hydrolase, SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.	1.19471e-09
NZ_CP042862.1\|WP_010149059.1\|832039_832321_-\|Rho-termination-factor-N-terminal-domain-containing-protein	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	4.142e-05
NZ_CP042862.1\|WP_010148931.1\|837639_837918_+\|DUF3618-domain-containing-protein	gnl\|CDD\|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	2.34793e-09
NZ_CP042862.1\|WP_010148925.1\|842842_843889_+\|NUDIX-domain-containing-protein	gnl\|CDD\|235825	PRK06547, PRK06547, hypothetical protein; Provisional.	3.25316e-38
NZ_CP042862.1\|WP_051125237.1\|831292_832012_+\|membrane-protein	gnl\|CDD\|225239	COG2364, COG2364, Predicted membrane protein [Function unknown].	4.49176e-43
NZ_CP042862.1\|WP_010148932.1\|837073_837550_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	1.70904e-69
NZ_CP042862.1\|WP_010148926.1\|841728_842781_-\|L-threonine-3-dehydrogenase	gnl\|CDD\|180054	PRK05396, tdh, L-threonine 3-dehydrogenase; Validated.	0
NZ_CP042862.1\|WP_010148933.1\|835966_836926_+\|homoserine-kinase	gnl\|CDD\|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	1.4443e-60
NZ_CP042862.1\|WP_010148927.1\|840525_841719_-\|glycine-C-acetyltransferase	gnl\|CDD\|235893	PRK06939, PRK06939, 2-amino-3-ketobutyrate coenzyme A ligase; Provisional.	0
NZ_CP042862.1\|WP_010148917.1\|850935_852078_+\|bifunctional-chorismate-mutase/prephenate-dehydrogenase	gnl\|CDD\|183035	PRK11199, tyrA, bifunctional chorismate mutase/prephenate dehydrogenase; Provisional.	0
NZ_CP042862.1\|WP_010148934.1\|834866_835967_+\|threonine-synthase	gnl\|CDD\|236013	PRK07409, PRK07409, threonine synthase; Validated.	0
NZ_CP042862.1\|WP_147899738.1\|833279_834074_+\|ribonuclease-PH	gnl\|CDD\|178914	PRK00173, rph, ribonuclease PH; Reviewed.	3.0546e-167
NZ_CP042862.1\|WP_141567737.1\|834070_834754_+\|non-canonical-purine-NTP-pyrophosphatase	gnl\|CDD\|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	6.78615e-87
NZ_CP042862.1\|WP_010148918.1\|849556_850795_+\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	9.08568e-48
NZ_CP042862.1\|WP_010148924.1\|844117_845233_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	3.52028e-58
NZ_CP042862.1\|WP_010148920.1\|846848_848411_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|379207	pfam13472, Lipase_GDSL_2, GDSL-like Lipase/Acylhydrolase family. This family of presumed lipases and related enzymes are similar to pfam00657.	1.76907e-09
NZ_CP042862.1\|WP_051125230.1\|848895_849558_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	3.02655e-104

>NZ_CP042862.1|WP_010148928.1|840089_840272_-|hypothetical-protein
MLRSGEVTVRAVLPRGTSGFRAGDTAYVSPRLEYARGFGLVVPGHVTSPRRVVTVSGSAA
>NZ_CP042862.1|WP_010148929.1|837937_840022_-|heavy-metal-translocating-P-type-ATPase
MDHARHPHDQHPAPTHDRAPAHGEEHAEHAGHGGHGDHVAQFRRLFWIMLVLAVPTVLTSGMFADLLGYSLPDLPGLTWVAPVLGTVMYVWGGRPFLTGAMSEIRSRQPGMMLLIGMAITVAFLASWGATTGLLDHRLDFWWELALLIVIMLLGHWIEMRSLAATSSALDSLAALLPDEAERVEGDTTVTVSPADLRVGDVVVVRPGASVPADGRIVDGSASMDESMVTGESTPVRREHGDAVVAGTVATDSGLRVEVTATGDETTLAGIQRLVADAQASSTRTQRLADRAAGWLFWFALGTAVITAIAWSVLGMPESAVVRAITVLVIACPHALGLAIPLVVSIATERAAKGGVLVTDRLALEAMRDIDTVLFDKTGTLTEGEPVVTAVAPVGGRGEQDVLRLAAAAEADSEHPLARAILRAAEGRDLDVPRAADFTSSPAVGVSATVEGARVQVGGPALLQEQGLAELDVVGDWRADGAIILHTVVDGQVIGALRLADGIRPESREAVEALHAADVEVVMITGDAQAVADSVARELGVDRVFAGVRPEDKAAKVAELQREGRSVAMVGDGVNDAPALAQADVGLAIGAGTDVAIGSAGVVLASSDPRSVLSVIDLSRASYRTMQQNLWWAAGYNLLAVPLAAGVLAPVGFVLPMSVGAILMSASTVVVALNAQLLRRLDLSPEASARRVRGS
>NZ_CP042862.1|WP_010148931.1|837639_837918_+|DUF3618-domain-containing-protein
MANKQPARSVKEIEADIAATRSRLARTVDELTYRVSPDTIKANAIASMKAKVNDTALDADGNPRYDRLATALGGVAAVALTLGGLRRVFNRS
>NZ_CP042862.1|WP_010148932.1|837073_837550_-|thioredoxin-dependent-thiol-peroxidase
MSRLEPGQPAPTWSLPTADGSRLSLADLAGRKVILYVYPAAMTPGCTTQACDFRDNEAIFTREGYAVVGVSPDPVEKLARFVEKEGLTFPLVSDEDKSMLTAYGAYGEKKNYGKTVVGVIRSTFVIDEAGVIEVAKYNVRAKGHVASLAKQLGVELPA
>NZ_CP042862.1|WP_010148933.1|835966_836926_+|homoserine-kinase
MGALTPGAVVRVRVPASSANLGPGFDSIALALGLWDEYAVEVLPEAGALEVVLAGEGVGEVPTDGRHLVAARLREALEACGLGWLDGYGLRLTCANTIPMSAGLGSSAAAIVGGLGLGFALVREGALTEADRGLVNTHAGVAEGHPDNSSASVYGGLTVSWMPSAQVVRTARPALHGDVVPVVLVPTGQRLDTATARAVLGPSVPRPDAARQAGRAALLVHALTSEPALLLDATSDWLHQEQRRGAYPVTMGAVDTLRGLGHAAVVSGAGPTVLCLTTADLADTVLAEARSWGRGWRVLTPGIPERGLHVVPPAGDDTP
>NZ_CP042862.1|WP_010148934.1|834866_835967_+|threonine-synthase
MAHQWRGVIAEYADRLPATITEQVVTLREGGTPLIPAEHLSELVGAQVHVKYEGLNPTGSFKDRGMTAAISDAARQGAKAVICASTGNTSASAAAYATKAGMECGVLVPDGKIAMGKLSQAIAGGATLIQVQGNFDDCLTLARKLAESYPVELVNSVNPARIEGQKTAAFEVVDALGDAPDIHCLPVGNAGNITAYWKGYGEYADASLAAPGAGGLAPATHRPQMWGFQAAGAAPIVKGHPVDDPETIATAIRIGNPASWAQAEAAREESGGVIEAVTDEEILAAHRLLSSREGIFVEPASAASVAGLLKRHAAGHVPAGATIVCTVTGHGLKDPQWALKGADGSDVDPVRVSVDVVSVADALGLE
>NZ_CP042862.1|WP_141567737.1|834070_834754_+|non-canonical-purine-NTP-pyrophosphatase
MSARRIVLATRNPGKVGELRDILADVLDRSGLELVGLDAFPELDDVVESGVTFAQNALLKARYAAAATGLPALADDSGLAVDVLHGAPGIFSARWSGPLGEATGRTKDEANNDLLLAQLADVPDEHRGAEFVCAAALVLPDARTPDAVVAAGGTAPQLAGSEWVREGRCRGVLAREPRGTNGFGYDPLLVRPDGRTLAEHTSEEKHAISHRGEAFRVLAVDVENLLG
>NZ_CP042862.1|WP_147899738.1|833279_834074_+|ribonuclease-PH
MTSRHDGRSADQLREIRITRNWLDHAEGSVLVEFGRTRVLCAASFTGGVPRWRKGSGKGWTTAEYAMLPRSTHTRSDRESVKGRLGGRTHEISRLIGRSLRAVVDLDALGENTIHLDCDVLQADGGTRTAAITGAYVALVDAVETARAKGLIAKKAEPITGSVAAVSVGVVDGEPVLDLDYPEDSTAETDMNVVMTGDGRFVEVQGTAEGTPFDRELLDALLDLAAEGCAELTARQAAAFGADDMGGTDSHEAGADVDQGPPTW
>NZ_CP042862.1|WP_010149059.1|832039_832321_-|Rho-termination-factor-N-terminal-domain-containing-protein
MAGEKKKDDPGPSVKDAEVYEALREDGASKEKAARIANAAAASSRSEVGERGGEAENYEDRTVEELRERAAELDIEGRSSMTKDELVEALRGH
>NZ_CP042862.1|WP_051125237.1|831292_832012_+|membrane-protein
MVGQTRRRALEGARSRAQDPRRQLAALGPVEQLRAGRLGRRLGQLLVGLWLYGVSIALMVRGVLGNMPWDVLHQGIARHLPLSLGTIIIGVSVLVLLLWIPLRQPPGLGTIANALLVGVAADVTLWLIEPGEGYAARAGLMALGVLLNGVASAMYIGAQLGPGPRDGLMTGIARRTGWSLRIVRTGIEVAVIALGWLLGGIVGVGTVVYAVAIGPLTQALLPWFTVTLPGADRSASEAR
>NZ_CP042862.1|WP_010148927.1|840525_841719_-|glycine-C-acetyltransferase
MYADVRDQLTDELAQIEADGLTKTERQITTPQSAHIATTAGEALNFCANNYLGLADHPDVVAAAHEALDEWGFGMASVRFICGTQTQHRDLERAIADFVGMEDSILFPSCFDANGGIFEVICGPEDAIISDQLNHASIIDGVRLSKAKRFRYANRDMDDLRVQLEAARDAGARRVLVVTDGAFSMDGYLAPLEQICGLAEEFGAMVMVDDSHATGFVGEGGRGSHEACGVLDRVDVMTGTLGKALGGGSGGYVAAHREIVDLLKQRARPYLFSNAVAPSVVAGSLKALEIARDSDEPRAQLRRNAELFRSLMTEAGFELLPGEHAIVPVMFPGDDGARRASQMADAMLERGVYVIAFSYPVVPKGQARIRVQLSASHSEDDVRACVEAFVAARDAVG
>NZ_CP042862.1|WP_010148926.1|841728_842781_-|L-threonine-3-dehydrogenase
MRALIKPSAGPGLELTDVPEPTPGWGEVKIRVLRAGLCGTDLHIAAWDDWAASMLEPPLVVGHEFYGEIVELGQGVPTDDDYGLAVGQRCSVEGHVVCGTCRNCRAGRRHMCVRTSNLGVNRDGCFADYVVVPHTNVWVQPEIIDPDLGAVFDPLGNAVHTALSFPLEGEDVLITGSGPIGVMATAIARHAGARYVVATDVVDARLELALAAGADLGINVARERIASAQERLGMSEGFDLVLEMSGNPQAMAELIDNCTHGARVAMLGLPAEPFAIDWGKVITHMITLKGIYGREMYETWYKMTAMLQTSEVLRDRIRSVITHRFPAEQWQDAFAAARSGEGGKVVMDWS
>NZ_CP042862.1|WP_010148925.1|842842_843889_+|NUDIX-domain-containing-protein
MDVRTRVGCYAWIERDGAVLLSRWRGLTTPDGRVARPAWTLVGGGIEPGETPEQAAVREVAEESGYAVRLGDVLVTDAWSGLDDRDLTGHEAWQAVQIVFTGEVVGGELTVEVDGSSDDVRWVPLEDLPDLRCVTIVDRAWRAAGGPGLPSSSLSFGPVDEQALGRLVEATDGAAPRCGDVRVVAVDGPSGSGKTVIARALAADLGAPLVQMDDLYPGWDGLAASPALLAQQVLEPLARGERAAYRRWDWHADDWATEPVEVAVEPGGVLVVEGCGSSIGPAGEHAAVRVWVDAEPGLRMRRGVARDGEAYRPHWERWAAQEEQVFGADHTRERADLVIDTTPAQVSR
>NZ_CP042862.1|WP_010148924.1|844117_845233_+|YihY/virulence-factor-BrkB-family-protein
MSTETRETRARAKTADDFEQAEGRAPDGPTDLGKTDWKAVLKRTMAEFGTDGGSDLAAAMTYYALMSIAPMLLALSTILGLVGQDGATETTINDLGGQLGVDDDTLTTVNDYIASMGSADGSGILLVVGLLGALWSASNYVNAFSRMMNTVYEVEEGRPVWKLRPWLLGLTVLCLLMLMTIVLAVSLSGSLSEAVFGVVGLSDQATMIWNIAKWPVILIILIGIIAVLYWGTPNVRQPSFRWLSPGAAIAVVVSCLAAAGFGIYVANFGNYNATYGALGAVVVLLLMIFIINNILVLGAELDAELERARELAAGMAAEETILLPPRDAKGTAKKLEKETEMVREARALRMQAAGRRRAAGETVGLEGRGRD
>NZ_CP042862.1|WP_010148923.1|845448_845622_-|hypothetical-protein
MHYLPKDVKTFLVREYLAGRSLRELTEITGRSHGAVRNILERAGAPRRGRGASRVKR
>NZ_CP042862.1|WP_158640853.1|845687_846632_-|hypothetical-protein
MRFGIRINRWRIHFRNNNPRFGVIGSGVSLPQVYFGPATSGAFTATPALIASDRTTGTVTRWQRTPIEAGVEYAISYSFSTTGITRRVVGGGWSASSVSSQSATLTRVVSLPLDAWIEAEIEPDVPVLAVFGDSLASGVGASLPVFESWLSIYCRRIGALPVHYTASGDTMAGWSNPFAHKWARWQHLSRPDAAFHAMGSNDVFAGASLDQMQERRATTMQILTEYVSPVIASTTLLPRSRLSGATEDTRRAYNAWLKTTPDEARDLCDMVPPVSRNDEDISPGFDCGDGVHLNASGYRSMQTAITRALVPTPA
>NZ_CP042862.1|WP_010148920.1|846848_848411_-|SGNH/GDSL-hydrolase-family-protein
MASGTNLDDIVEPGFYPGFAADPINKPGGASSGFLTVAELSTGVATSVRQEWQDYGMYGTWRRNRGTGGWGPWLRTDDIPRVAEPLATGNATTVGPGRHDVPNAHTVTGLPSAEGGLLTRTGVIDTYVTRGEVSSTFERRLRPDGLWTTWARIAGEKVAPLAITRPQAMLTETNTSRSVRTPFTVPTRVRKWRVVIRNANYRTNTAYAGGVTIRTLCVGTADHDAAGAITSSFTPSGTFPSGLRIILRDASVADMGAGYTSPWVTSELVPGVDYMMSLGYQTNGQEVHLGMGGGWWTNGNPMNAELTSGPTGAAVKRLPFDIRIETVLDTDDPVDVIIGDSIAAASSATLPVREAPLAIANRSAGRAVRTHAFGGAAMSEWIGVNWGDPASMKWTDVTNYGPADRVLIALGNNDIHAGTNLKTLQANLATLVGLVRERLTSTVLVATVTPRTAWTGTANETLRAAFNNWLRSFPAGIDGIVDQAAAVENEAGNAPRADLVATDGIHFTSSGTAALASAIR
>NZ_CP042862.1|WP_051125230.1|848895_849558_-|oligoribonuclease
MGPRVPGAGGILLSAVSGERIVWIDCEMTGLDTVEDALVEVACLVTDSELNVLGDGVDVVIRPPDAAVEQMGDFVRAMHTESGLLPELDSGVTLEEAQQRVMEYVRAHVPEGRKAPLGGNTVSTDRAFLARDMPELDAYLHYRIIDVSSIKELAKRWFPRAYYMAPAKTGGHRALGDIVDSIAELRYYREAVFRELPGLDSDTLREIATRHTAPEATPDA
>NZ_CP042862.1|WP_010148918.1|849556_850795_+|PrsW-family-intramembrane-metalloprotease
MVNQSQPPSSSLPNAPGQRAPQDPGKGGDWHQVMSFQPQSPESARPNATRRPVIRRVLLWSAVVTVFGLAALAMTLIVTTAVGLQAAILGMVSASLALGIVIPLFIWVDRLEAEPARLLWFAFLWGALISTLGALVLNELGVAFFAGRHADPLVVGAVVVAPLTEEFFKGLGVLLIFLFAKREFNGVTDGIVYAGIVAAGFAFVENIIYLGQMYLDAGPVGLVGIFIMRCLVSPFAHPMFTVCIGLALGLVAHRRRFSSVWVVLVGFACAVFLHALFNYSAVAASQYYLVLFALVQVPLFIGFLLLLRWARNRESRLLRDTLTGYGMAGWYTPAEVAMLASPGERRRARHWARGVGGRPAEQAMQAFQDESGELAMVRKHLVHGGPDAVWLGREQRILEAVTAHRRVFVPQG
>NZ_CP042862.1|WP_010148917.1|850935_852078_+|bifunctional-chorismate-mutase/prephenate-dehydrogenase
MTTPPGAQEPLAALRAQIDDVDAQVMELLAQRLELVAQVGEVKGRHGLPIYDPERERAMIARKREHAAERGLSPDLVEDVLRRCMREAYTHEKNMGFTRQAPDLGPIVVVGGRGRMGALFGRMFTLSGYDVRVVERDDTPEQVAEAVAGAGLVLVSVPIHDTVQVVRDLPPLPEDCLLVDLTSTKRAVMEAMLATHTGPVLGLHPMFGPDVDSFAKQVVAAVPGRDAQASTWLLEQIRLWGARVHEVDADEHDHAMGLIQALRHFSTFAYGWHLAHEDRNLDTLLALSSPIYRLELIMVGRLFAQDAELYFDIITGSSDALELIERYHERYTQAIELLRTGDREAFVRQFGEVEGWFGEHAERFLVESKSLLAHADSTRP

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Crispr_ID: NZ_CP042862_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_4

1334716-1334842

Orphan

Consensus_repeat	Method
CGGGCGGTGCGCAGGGTGGCGGTCAGCGGCCCTCGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042862_4

>merge|NZ_CP042862|4|1334716-1334842|CRISPRCasFinder
CGGGCGGTGCGCAGGGTGGCGGTCAGCGGCCCTCGCGGCGCAGCGATCTCGCGACAGGCCCGATGGCCTTGTGGGACAAGCATCTTCGCCGGGCGGTGCGCAGGGTGGCGGTCAGCGGCCGTCGCGG

>NZ_CP042862|4|4|1334716-1334842|CRISPRCasFinder
CGGGCGGTGCGCAGGGTGGCGGTCAGCGGCCCTCGCGG	CGCAGCGATCTCGCGACAGGCCCGATGGCCTTGTGGGACAAGCATCTTCGC
CGGGCGGTGCGCAGGGTGGCGGTCAGCGGCCGTCGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_029540657.1\|1332205_1334605_+\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NZ_CP042862.1\|WP_147899774.1\|1342268_1343465_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_010147039.1\|1343771_1344932_-\|M20-family-metallopeptidase	unknown	unknown	gnl\|CDD\|349881
NZ_CP042862.1\|WP_010147209.1\|1326051_1327587_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|184134
NZ_CP042862.1\|WP_010147211.1\|1324215_1324911_+\|TIGR02206-family-membrane-protein	unknown	unknown	gnl\|CDD\|378199
NZ_CP042862.1\|WP_010147205.1\|1330975_1332154_-\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|173840
NZ_CP042862.1\|WP_010147042.1\|1341045_1341849_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|238038
NZ_CP042862.1\|WP_010147217.1\|1320125_1320959_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP042862.1\|WP_010147038.1\|1344943_1346191_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|349914
NZ_CP042862.1\|WP_147899772.1\|1320961_1321870_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP042862.1\|WP_010147043.1\|1340362_1340848_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274679
NZ_CP042862.1\|WP_010147046.1\|1337326_1338193_+\|DUF2236-domain-containing-protein	unknown	unknown	gnl\|CDD\|378343
NZ_CP042862.1\|WP_010147206.1\|1328707_1330942_+\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_CP042862.1\|WP_010147045.1\|1338189_1338732_+\|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl\|CDD\|379265
NZ_CP042862.1\|WP_147899773.1\|1335488_1336004_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_147899890.1\|1321869_1323153_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270303
NZ_CP042862.1\|WP_010147047.1\|1336224_1337169_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381307
NZ_CP042862.1\|WP_010147044.1\|1338728_1340216_+\|cryptochrome/photolyase-family-protein	unknown	unknown	gnl\|CDD\|225588
NZ_CP042862.1\|WP_081480533.1\|1327616_1328711_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380488
NZ_CP042862.1\|WP_033228788.1\|1323645_1324200_+\|murein-L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_029540657.1\|1332205_1334605_+\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	0
NZ_CP042862.1\|WP_010147039.1\|1343771_1344932_-\|M20-family-metallopeptidase	gnl\|CDD\|349881	cd03885, M20_CPDG2, M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme. Peptidase M20 family, Glutamate carboxypeptidase (carboxypeptidase G; carboxypeptidase G1; carboxypeptidase G2; CPDG2; CPG2; Folate hydrolase G2; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; E.C. 3.4.17.11) subfamily. CPDG2 is a periplasmic enzyme that is synthesized with a signal peptide. It is a dimeric zinc-dependent exopeptidase, with two domains, a catalytic domain, which provides the ligands for the two zinc ions in the active site, and a dimerization domain. CPDG2 cleaves the C-terminal glutamate moiety from a wide range of N-acyl groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl, and pteroyl groups to release benzoic acid, phenol, and aniline mustards. It is used clinically to treat methotrexate toxicity by hydrolyzing it to inactive and non-toxic metabolites. It is also proposed for use in antibody-directed enzyme prodrug therapy; for example, glutamate can be cleaved from glutamated benzoyl nitrogen mustards, producing nitrogen mustards with effective cytotoxicity against tumor cells.	1.14547e-111
NZ_CP042862.1\|WP_010147209.1\|1326051_1327587_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|184134	PRK13549, PRK13549, xylose transporter ATP-binding subunit; Provisional.	0
NZ_CP042862.1\|WP_010147211.1\|1324215_1324911_+\|TIGR02206-family-membrane-protein	gnl\|CDD\|378199	pfam09529, Intg_mem_TP0381, Integral membrane protein (intg_mem_TP0381). This entry represents a family of hydrophobic proteins with seven predicted transmembrane alpha helices. Members are found in Bacillus subtilis (ywaF), TP0381 from Treponema pallidum (TP0381), Streptococcus pyogenes, Rhodococcus erythropolis, etc.	2.68155e-16
NZ_CP042862.1\|WP_010147205.1\|1330975_1332154_-\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
NZ_CP042862.1\|WP_010147042.1\|1341045_1341849_-\|HNH-endonuclease	gnl\|CDD\|238038	cd00085, HNHc, HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.	0.00886756
NZ_CP042862.1\|WP_010147217.1\|1320125_1320959_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	8.02824e-70
NZ_CP042862.1\|WP_010147038.1\|1344943_1346191_+\|amidohydrolase	gnl\|CDD\|349914	cd05664, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, Uncharacterized subfamily of proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in the hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	1.81619e-171
NZ_CP042862.1\|WP_147899772.1\|1320961_1321870_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.89049e-66
NZ_CP042862.1\|WP_010147043.1\|1340362_1340848_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	1.39488e-32
NZ_CP042862.1\|WP_010147206.1\|1328707_1330942_+\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.84433e-64
NZ_CP042862.1\|WP_010147045.1\|1338189_1338732_+\|2'-5'-RNA-ligase-family-protein	gnl\|CDD\|379265	pfam13563, 2_5_RNA_ligase2, 2'-5' RNA ligase superfamily. This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	0.000307341
NZ_CP042862.1\|WP_010147046.1\|1337326_1338193_+\|DUF2236-domain-containing-protein	gnl\|CDD\|378343	pfam09995, DUF2236, Uncharacterized protein conserved in bacteria (DUF2236). This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	1.23036e-50
NZ_CP042862.1\|WP_147899890.1\|1321869_1323153_-\|extracellular-solute-binding-protein	gnl\|CDD\|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.79872e-48
NZ_CP042862.1\|WP_010147047.1\|1336224_1337169_-\|aldo/keto-reductase	gnl\|CDD\|381307	cd19081, AKR_AKR9C1, AKR9C family of aldo-keto reductase (AKR). Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).	8.72165e-130
NZ_CP042862.1\|WP_010147044.1\|1338728_1340216_+\|cryptochrome/photolyase-family-protein	gnl\|CDD\|225588	COG3046, COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only].	1.17252e-149
NZ_CP042862.1\|WP_081480533.1\|1327616_1328711_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	5.90522e-77
NZ_CP042862.1\|WP_033228788.1\|1323645_1324200_+\|murein-L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.10782e-12

>NZ_CP042862.1|WP_029540657.1|1332205_1334605_+|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MSELLRGTSILGTEVRRVEDPDLLRGRGTFVGDLDLDDPDVLHAVFVRSPVAHARIAGIDAAEAVAADGVVGVFTADDLGSDPVPPFAQIHDRVARTALAVDRVRFVGDPVALVVARSRAAAVDAADLVDVDYDELEVVVDLEDALDQDAVQQFPELGTNVVLAVKDPDGEPDVLAGAHRVARLRMENNRMATSPIEGHGILGRPTASGGAADDADAEVTGLDVALATQHPHLAHRLLVRWTGLSREAVRVRAPHVGGAFGGKAGIIPEHAAVVRASCQLGRPVRWVETRSETMLSMTSRGQVQYVEVGLDEDGTITGMRARLVGDCGAYAGFGGSFASGSTRTMSEGSYVIPALRYEAVSVMTNTAPTGAFRGAGRPEAAAMVERAMDHAARVSGLTPEEFRRRNFVAADAFPRTTKFGARYDTGDYAKALDAALEAAGVEELRAEQARRRQEGSAWQLGIGIASYVEITGFGGSEYAGIRVDRDGSLTVMAGTSAHGQGHATAFSMLVADQLGVPLERVRYVQSDTALVRSGGGTGGARSLQLGGSAVLGAAVELREQATRLAAELLEVADADVELVEGSFGVRGVPGASLTWEEVAAHAHDQGEGLVVDHDFTQDGSTFPFGTHVSVVEVDVETGAVRLLRHIAVDDCGTVVNPLLVRGQQHGGCVQGIAQALFEEFRYDEWGNPITGTFADYTLPTAVDVVQLETSLTTTPTDRNPLGAKGIGEAATVGSTPAVQNAVVDAVAHLGVRHVDLPCTPERVFRAIQEGVGGEQDPWREPPAIFDDLPDLNAVDDVEV
>NZ_CP042862.1|WP_010147205.1|1330975_1332154_-|acyl-CoA-dehydrogenase-family-protein
MPAAPSLDLLDLDSLLDDDERAVRDSVRAACAELVLPHVAGWYEAGDLAPEQVRELALEFGRLGVLGMHLEGYGCAGMSAVDYGVACTELEAADSGIRSLVSVQGSLAMHAIHAYGSEDQKQSWLPPMARGEAIGCFGLTEPDHGSDPGSMTTRARRDGTDWVLDGAKTWITNAPLAEVAVVWARTDDGIRGFVVPTSTPGVSTPTIHRKMSLRASVTGEIVLERVRLPQDAVLPGVRGLKGPLSCLSEARYGIVWGAMGAARSALLTALEYAGTREQFDRPISAFQLTQAKLAQMHQSWATGMLLALHLGRLKDRAGLRPEQVSVGKLNNVGAALEICRTARTILGANGISGDYPIMRHAANLESVLTYEGTAEMHTLVVGQALTGEQTYR
>NZ_CP042862.1|WP_010147206.1|1328707_1330942_+|acyltransferase
MSRVVGRRPRPGFRPDIEAMRAIAVLLVLLYHAGVPWLPGGFSGVDVFFVVSGYVITALLVGEVRRTGSVDLPRFWARRARRLLPASALVLATTVLLTLAWVPQVRWREIGWDVVASGLYVINWRLADRSVDYLAEDSVASPVQHYWSLAVEEQFYLLWPVLLLAAAWLARRLGRDVVAVTALVLAVAVVLPSFGWALHLTAVSPDEAYFVTPTRLWQLGAGALVALGGAWWARVPVPLATGLAWAGPVAVFAAGVLVDAQTPWPGWATLVPTLGVAAMLVGGVRASAALGPARLYAWPVLQWIGALSYSLYLWHWPLIVLAEARWGELSVWAGLGVVVLSAVPATLGYLLVEQPVRHAWGRWALPRTGLAIGLVCTLLAAGSGGLLVREIDRQVRANEAVAGEADGAGALTGERAPSPSTPAGARSGSRAGEQVGGLDEQTDGGGDEAGDGTQEEPEERQVPGGTAGAPSPDLGGLDLSPEAITPDPLEATRDLPSLYDEGCDATDEEVVRCDYGDRDGDLHVAVVGDSKIAQWASALDLAGQERGWRVDVYYRSACPWSATLVQVADEEAAQACRRWGAEVGQRLLEEPPDVVLTSSVKSRGVGADGELSGRALADGMAQRWQEIGSAGIPVVALADTPQPRMQVYACVADHRDDLGRCAIDYNRGSGTGPLLRAVEAVPTSSFVTMNDWVCPGQDRCPPVVGGVLVYRQGSHITDTYARSLTDVLADRLEAAFAELGVEAA
>NZ_CP042862.1|WP_081480533.1|1327616_1328711_+|substrate-binding-domain-containing-protein
MPCLPAAAARAGRARAAAAGRGSLGDAGVDLLLGPVAGVDEHLGDAVLVDDVGLEEERRDDLDAVVVALGVAGLRLAAVEVGLDADDRLLGQLAGVLEDRGVLHVVVDELDRGDLGVLAGHDGQPLLDGRAHARVLQRRDVEGLAVIAPTDGQAEMVAGLVGQLPVVAVEGRLADEVPFVSSDNEAGGRMVADHLLEHGHRVIAHVSGPEDWGEARQRSAGWARRLDEAGAEPGPRWAGDWGPGSGYRAGQELLAHPRWPEVTAVFAANDSMALGLMAALHQRRVEVPQRVSVMGYDNTPESGWFFPALSTVEQQFDAVGAAAVERLVALLEGGAESEDLLVPPRLVSRSSVAREGSRSLDSAG
>NZ_CP042862.1|WP_010147209.1|1326051_1327587_-|ATP-binding-cassette-domain-containing-protein
MSDTILEMQGITKTFPGVKALEDVTLEVRRGEIHAICGENGAGKSTLMKVLSGVYPHGSYDGQIRFDGEEVRFSSINDSEAQGIVIIHQELALVPRLSIAENMFLGNERLGPGRLIDWHRTNRDAAELMERVGLKELPVTQVNHIGVGQQQLVEIAKALSKDVRLLILDEPTAALNDNDSGHLLSLLRQLQEQGVTCIMISHKLGEIADRTTIIRDGRTIETIDMSEPESTQDRIIRGMVGRDLEHRFPERESTIGEEMLRVEDWTVYHPTQAERLIIDKADFTVHAGEVNGIAGLMGAGRTELAMSLFGRSYGCNISGRVFKQGKQITMRSVDEAIAHDVAYATEDRKAYGLNLIDDVRHNTSAAGLFKLSRLGWVNGLEELKIAQDYRTSLNTKTPSVLSTVGKLSGGNQQKVVLAKWLYTDPDVLILDEPTRGIDVGAKYEIYTIINRMVAAGKAVIVISSELPELLGISDRIYTLAFGRITGEVPVADATQERLMALMTTVKEGASR
>NZ_CP042862.1|WP_010147211.1|1324215_1324911_+|TIGR02206-family-membrane-protein
MGDFLDPEPGWITIGGREHLVYVLGLVVLALALVCGRRVVREHAVGVRAALAVVVVAQQVALYGLYLATGWDPAETLPLHISRVSALLGLGYLLTGSRRVMDVLFYFGLWAWASFAYPQQIQPPTTLLGVSFFVNHAITLLLPALAWITTDWRPSIRALWRALGWFGVYLGVAVMANRAFGGNYFYQRERPLLPWLEQPWYLLVSVLATVALFWLGYAVSRLAQLPARRLL
>NZ_CP042862.1|WP_033228788.1|1323645_1324200_+|murein-L,D-transpeptidase
MLQEELNAAGYWCGPPDGGFGHLTQQAVWAVQKAHGLWRDGVVGPGTRAALATGYRPAPAYGGDHVEVHLASQLLLVVRGGATLMTLNTSTGNGESYTFKDKDYDAKTPTGDYTVWLTHSKGWQDGELGEMYRPMYYSGNYAIHGSESIPPVPASHGCARISVPAMEMFWSQGLLAKGHRVIVL
>NZ_CP042862.1|WP_147899890.1|1321869_1323153_-|extracellular-solute-binding-protein
MPPLSRRRLLTLGGVGALGATLAACGDNTGRGGTPTPDGGSASGAGRPSIAQWYHQYGEAGTQEAVERYAAEYDAADVTVSWKPGDYDQSTAASLLTDSGPDVFEYGNGPTIDMIRGEQVADLTDLFGDTLDDFTPSLIERMSYDGRIWAVPQVLDMQVLVYRKSLLEEAGVQPPQQIPELLAAAQELTRGDVKGLFLGNDGGAGLLGGPMLWAAGLDYLDGDRVGFQDAGAAEALSTLRTLWTDETLLLGEAKDWFDAEAFISGRAAMQWTGLWTFPAISEALGDDFGAIPWPVLEGGAPSVPVGAYGACVSTRAADVEAAKAFVRWLWIEQTDKQLDFATAYGFHVPSRVSLIPEADVLSSGPAADAASYVKEFGHAQTPLLWTPRSATAWSDMMSRIVRDGADPQSELDALVPIVEDELERVTG
>NZ_CP042862.1|WP_147899772.1|1320961_1321870_-|ABC-transporter-permease-subunit
MLARLRGRQDVNLWFWVFVGPFFAGLVLFIYVPIGWSIYLSFFEAYNTVTPTEFVGMANYRDMLTDRAFRDSLLTFVVFAAFIVPTTFALSLLTAVLVARTRVMQAFFRSVFFLPVACSYVVAALIWKMSIFSGMRSGVANALLGLVGASPIPWLSLTDPPWYWLVIVSARLWLQVGFYMILFLAALQRVPTNLYEAAAIDGAEGWQVFRHITWPQLVPASTAVLLLLLINAFQAFDEFYNILSGFGGYPPYARPPLVYLYYTALGTGQNFGDGSAGAVILTVLIAALALAQTRLLRLGGRD
>NZ_CP042862.1|WP_010147217.1|1320125_1320959_-|carbohydrate-ABC-transporter-permease
MLHERRRYAVLRRVLLGLGTLLFLVPFYLLVRGAFSTEADLTSATWHWLPPTWEWGNLRAVFDNPTVPMGRALLNSTLIAVSQTVGVLVLSGMAGYGLARIPYRWSNAVFWLITVTLLIPAAVTFVPSFVLVSTLGWISTLRGLIVPGLFQALATFLFRQFFLSFPKEIEEAAALDGLSWWGTFWRVVVPNSGGFAAAIGTITFIGSWNAFLWPLVIGRTPDSWTVQIALSTYLTAQTSQVSLLFAAALVAILPLLLMFLLLQRWIVQGVERTGISE
>NZ_CP042862.1|WP_147899773.1|1335488_1336004_-|hypothetical-protein
MTADTRIVGVLDRVLAAVDAAAGNVAQTARHDGRHLQQAASDLQAAPQPGTIEPVERGRVVGPVLGRAEPHRRGPSIDLQPSAPVMGHADPYHRGPTITDEPSTPVMGHADPYHRGPTITDEPSTPVMGHADPYHRGPTITDEPSTPVMGHADPYHRGPTITDETPGTEDS
>NZ_CP042862.1|WP_010147047.1|1336224_1337169_-|aldo/keto-reductase
MQTPTFPGTDRPFAPINLGGNPFGWTSSRESSEAVLDAFLAAGGSFVDTADAYSAWAEGHEGGESEPILGQWMADRGNRDQVLVATKVGKKPGREGLAHDSVLAALEESLERLQTDYLDLYYAHADDEQVAIEDQVATFDEVARSGRVRAIGLSNYSPDRLRAFMETAAAQGAVLPTAIQPRYSLVSRSAYETDLAPLVAEFGLAVFSYPALASGFLTGKYRTEADFAGNARGGAARRYAEAGGFAVVDALVTVAGRHGVDPASVALAWLLDRGVTAPIASASRPEQLEPLMAATRLELDDQDRAELDAASSTF
>NZ_CP042862.1|WP_010147046.1|1337326_1338193_+|DUF2236-domain-containing-protein
MIGRVQTALGSALRSRVAGDDARERAALIWDTPGARWFTPEDPVWRVHADASMFPGGVAALLLQMLHPMAMAGVAGHSGYKGDPWGRLQRTSTYLAATTFGTIEHALDTIGHVRSIHERVRGKDAFGRPYRASDPHLLTWVHVAEAVSFLDAYQAFSGSPLTEEEADRYVAQAGVSAGHLGVPDPPSSVRELRDVLEAYRPELEATDAAREAARFLLADPPLPVVSRPGYWAIAAGGVALLPPWSRSELGLPASPVLSRVVLSPLGRVSTSTVRWAMAGVERAETEAA
>NZ_CP042862.1|WP_010147045.1|1338189_1338732_+|2'-5'-RNA-ligase-family-protein
MSPSHALELVLTPADDAQVRSRWGALEAAGVASLARHRGSTHRPHLTVASSPHAPGEQVLAAALELWAPLLPLPLEVSGLVLLGGRRLTIAELVAAPLSARRAQAVLAQQWEGADQRPWVPHVSLAARLTVDDAGAALSALADDRWASPAVEGGRTLTVRGLRWWDPQVQSVSAVVGAAA
>NZ_CP042862.1|WP_010147044.1|1338728_1340216_+|cryptochrome/photolyase-family-protein
MSRTTEVRLVYPHQLHSAQLEVPDGTVLVVVEDDLLYRQLPFHAHKLVLHRAAVRRFVDRAQERSFDVEVVESSPERTSGSGLVELVHRLRPSRVSVLDVADDWLGRDCRDQLREGGYELRPEDVLDTPAFLTTRRQIKDHFSAGGARMQHFYAWQRRRLDVLMEGDQPVGGRWSFDTENRKKLPAGHPVPEPALGPVRRHTHVTEAIAWVAEQFPDAPGDPETFCWATSPGEADAALRRFLDERFSQFGPYEDAISTEHPVLFHAALTPALNCGLIEPEQVLERALVAADDHDVDLPSLEGFVRQLIGWREYMRATYRLWGRRMRTSNVLEHGRSMPASWWTGDTGLEPVDLVIRRVLERGYAHHIERLMVLGNALCLLRVHPDEVYRWFMAMFVDAYDWVMVPNVYAMSQFAAGEAITTKPYVSGSNYLRKMSDLPPGEWRQAWDGLYWTFVEDHREVFEANSRSGFAVRSWDGMASDKQRAHRDAAAPWLGR
>NZ_CP042862.1|WP_010147043.1|1340362_1340848_-|PPOX-class-F420-dependent-oxidoreductase
MPRTIATTTDVELEQLLDFARTRHNLVLITQRQDGNPQASPVTGGVDDEGRLVISTYPERAKTANARRHPEVSVLVLSDDFGDAWVQVDGSCEVLDGEDAVEPLVDYFRCISGEHPDWDEYRQAMRDQGKSLIRVTPTRWSPIATGGFPARLSEAGQHPDS
>NZ_CP042862.1|WP_010147042.1|1341045_1341849_-|HNH-endonuclease
MIERSIAAYRPDAAMRRQIVAADVYSRAPGSRAPAVACEIDHEQPFGSGGPTRESNLALKDVRSHQFKTEGWWSSALAPRRDLTWETILGQIEQTRGHDYRQYLPSARTTGVTTTVTTSDPRDGTHPDAAVTDPAAPSALDAVDEPGRPTPEDDLDLACRALYSALAHRGVGALLADPDDADGATDHDPRLTGWITLTHRGQDGQRRGGAPEDLATVASLLGFSSPTVADASDASDASADRRDMKRGHDTAESTPPWREPRDEPPPF
>NZ_CP042862.1|WP_147899774.1|1342268_1343465_-|hypothetical-protein
MLEYRLAELCAHRALELAHGVHCVDLRPFGLTLTVPGLQPDVSAPPFPVDDARPPDDEARPPDDEARPSTSADPTPRQPPCDAVQRVRSIAHQRSAMEARLLGAAQDLTAEIGAALLADKGYADVDELTPARRRKWAETKRLACAELQVALGLGVREARQLVGVACAPAPVRTVVAEALETGLASWGHVRAFWERCGTLPADEAPLVSESLFGADPDLAVPERLAPDGTLLDRPWHQAEFWAALEREAVRVEGQDVLAERERRHRARAERRVWMRVDDDSTATLAVTGPLTSVCAISQRIDACAKALRKSGDERTLAQLRSDVAQTLLLHGRLDLPGRAEGTLTTPPTGRTLPTGPTGDPLLTPAESEAVAQIVTAQPSITLEVVVPFDALTGQPACT
>NZ_CP042862.1|WP_010147039.1|1343771_1344932_-|M20-family-metallopeptidase
MPTTHASAVRTVVEEHLEEVLGDLELLVGLETPSRRRDLLEVALPRIEAYLVQRLGEPSRRVQHDGGEFGDVLDLTWPGVGARGEVLFLAHYDTVWPEGTLDGWPLTRDGDVLTGPGVLDMKVGIVQTVWMLLALRRLGVPHPDVRLLLTPDEEIGSRAGRAHLEAAASDALATLITEPSAAGAVKTRRKGMVFADVTVHGVESHAGLDPEAGASAVHELAGLVPQLVALADRERETTVNVGTITGGSGRNVVAGRATCEVDVRIQEPAEEDRVVGALEALHVSDERCRLEVDIDRNRPPMNPTPHTARLLELVRTVGDDLGVDVGDEAVGGASDGNFIAALGLPVLDGLGGIGAGPHARHEHILVSGIPRQTALMAGLVELLGRG
>NZ_CP042862.1|WP_010147038.1|1344943_1346191_+|amidohydrolase
MSQTTSILESAEHADLRESLHELYRHLHAHPELSMQEEATAALIEERMGGLGYDVFRCGGTGVVATLRNGEGPVVGFRADTDALPVEEDTGLEYASTARGTMPDGTDVPVMHACGHDMHVTAAIGAATLLAGDREAWSGTVVFLFQPGEETAQGAVSMLDDGLWERAERPEVIYGQHVWPGITGTIDVTPGPAMTFSDAWRVTVRGRGGHGSQPESTIDPVVLAAHMIVRIQSLKSREVPAQKAAVITIATIHAGLKENIIPATAEFTVNMRNLDADVREHLLGALRRVILAEAMASDAPEPVIEEIYTFPLLVNDEEETARVIEVLRGAIGEEQVNEIPAVMGSEDFGALPDAIGVPGVYWFFGGLTREEVEGEEPTVTNHSPHFGPQLEPTLGIGVSAAYAVLTSRLRPGGVG

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Crispr_ID: NZ_CP042862_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_5

1935884-1935957

Orphan

Consensus_repeat	Method
CGCGAGGTATGCCGTGGGCGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042862_5

>merge|NZ_CP042862|5|1935884-1935957|CRISPRCasFinder
CGCGAGGTATGCCGTGGGCGCCCGGGAGCTGCGTCACCCGGCAGGCCTCACCACGAGGTATGCCGTGGGCGCCC

>NZ_CP042862|5|5|1935884-1935957|CRISPRCasFinder
CGCGAGGTATGCCGTGGGCGCCC	GGGAGCTGCGTCACCCGGCAGGCCTCAC
CACGAGGTATGCCGTGGGCGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_010146571.1\|1931591_1932593_+\|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274834
NZ_CP042862.1\|WP_010146575.1\|1925885_1926530_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_010146566.1\|1934820_1935774_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|379128
NZ_CP042862.1\|WP_010146567.1\|1933820_1934579_+\|ROK-family-protein	unknown	unknown	gnl\|CDD\|224851
NZ_CP042862.1\|WP_141567498.1\|1926540_1929741_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	unknown	unknown	gnl\|CDD\|237613
NZ_CP042862.1\|WP_010146559.1\|1943053_1943992_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP042862.1\|WP_010146560.1\|1942169_1942928_+\|peroxide-stress-protein-YaaA	unknown	unknown	gnl\|CDD\|234999
NZ_CP042862.1\|WP_010146556.1\|1945079_1945817_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224495
NZ_CP042862.1\|WP_010146562.1\|1939761_1940655_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|369792
NZ_CP042862.1\|WP_010146572.1\|1931190_1931538_-\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|226219
NZ_CP042862.1\|WP_010146568.1\|1932890_1933751_+\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_CP042862.1\|WP_010146564.1\|1937426_1938098_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|225130
NZ_CP042862.1\|WP_010146576.1\|1925181_1925889_-\|phosphoribosyl-isomerase-A	unknown	unknown	gnl\|CDD\|237589
NZ_CP042862.1\|WP_051125096.1\|1938114_1939233_-\|VIT1/CCC1-transporter-family-protein	unknown	unknown	gnl\|CDD\|153124
NZ_CP042862.1\|WP_033228586.1\|1946806_1947274_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|239316
NZ_CP042862.1\|WP_010146561.1\|1940651_1942121_-\|RNB-domain-containing-ribonuclease	unknown	unknown	gnl\|CDD\|223631
NZ_CP042862.1\|WP_010146555.1\|1945813_1946713_-\|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl\|CDD\|376614
NZ_CP042862.1\|WP_010146573.1\|1929857_1931186_-\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
NZ_CP042862.1\|WP_033228590.1\|1932615_1932825_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_158640866.1\|1944207_1944888_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_010146571.1\|1931591_1932593_+\|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274834	TIGR03885, putative_dehydrogenase_protein, probable non-F420 flavinoid oxidoreductase. This model represents a clade of proteins within the larger subfamily TIGR03557. The parent model includes the F420-dependent glucose-6-phosphate dehydrogenase (TIGR03554) and many other proteins. Excepting the members of this family, all members of TIGR03557 occur in species capable of synthesizing coenzyme F420. All members of the seed alignment for this model are from species that lack F420 biosynthesis. It is suggested that members of this family bind FMN, or FO, or a novel flavinoid cofactor, but not F420 per se. [Unknown function, Enzymes of unknown specificity].	1.47546e-95
NZ_CP042862.1\|WP_010146561.1\|1940651_1942121_-\|RNB-domain-containing-ribonuclease	gnl\|CDD\|223631	COG0557, VacB, Exoribonuclease R [Transcription].	1.25451e-64
NZ_CP042862.1\|WP_010146566.1\|1934820_1935774_+\|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein	gnl\|CDD\|379128	pfam13338, AbiEi_4, Transcriptional regulator, AbiEi antitoxin. AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	9.4831e-05
NZ_CP042862.1\|WP_010146567.1\|1933820_1934579_+\|ROK-family-protein	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	5.12231e-41
NZ_CP042862.1\|WP_141567498.1\|1926540_1929741_-\|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase	gnl\|CDD\|237613	PRK14109, PRK14109, bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase.	0
NZ_CP042862.1\|WP_010146559.1\|1943053_1943992_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.37457e-12
NZ_CP042862.1\|WP_010146560.1\|1942169_1942928_+\|peroxide-stress-protein-YaaA	gnl\|CDD\|234999	PRK02101, PRK02101, peroxide stress protein YaaA.	8.52513e-59
NZ_CP042862.1\|WP_010146556.1\|1945079_1945817_-\|hypothetical-protein	gnl\|CDD\|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	1.25091e-29
NZ_CP042862.1\|WP_010146562.1\|1939761_1940655_-\|HAD-family-hydrolase	gnl\|CDD\|369792	pfam08282, Hydrolase_3, haloacid dehalogenase-like hydrolase. This family contains haloacid dehalogenase-like hydrolase enzymes.	1.32534e-54
NZ_CP042862.1\|WP_010146572.1\|1931190_1931538_-\|MGMT-family-protein	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	9.08808e-16
NZ_CP042862.1\|WP_010146568.1\|1932890_1933751_+\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	4.34965e-139
NZ_CP042862.1\|WP_010146564.1\|1937426_1938098_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	3.07229e-23
NZ_CP042862.1\|WP_010146576.1\|1925181_1925889_-\|phosphoribosyl-isomerase-A	gnl\|CDD\|237589	PRK14024, PRK14024, phosphoribosyl isomerase A; Provisional.	4.56295e-47
NZ_CP042862.1\|WP_051125096.1\|1938114_1939233_-\|VIT1/CCC1-transporter-family-protein	gnl\|CDD\|153124	cd02433, Nodulin-21_like_2, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_2: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	1.68654e-82
NZ_CP042862.1\|WP_033228586.1\|1946806_1947274_-\|peroxiredoxin	gnl\|CDD\|239316	cd03018, PRX_AhpE_like, Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater similarity to 2-cys PRXs than 1-cys PRXs. PRXs are thiol-specific antioxidant (TSA) proteins that confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF. The first step of catalysis is the nucleophilic attack by the peroxidatic cysteine on the peroxide leading to the formation of a cysteine sulfenic acid intermediate. The absence of a resolving cysteine suggests that functional AhpE is regenerated by an external reductant. The solution behavior and crystal structure of AhpE show that it forms dimers and octamers.	1.03777e-61
NZ_CP042862.1\|WP_010146555.1\|1945813_1946713_-\|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl\|CDD\|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	3.0974e-80
NZ_CP042862.1\|WP_010146573.1\|1929857_1931186_-\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	1.03637e-175
NZ_CP042862.1\|WP_158640866.1\|1944207_1944888_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	4.40057e-45

>NZ_CP042862.1|WP_010146566.1|1934820_1935774_+|type-IV-toxin-antitoxin-system-AbiEi-family-antitoxin-domain-containing-protein
MNPALEGFLRTHHFGITTAEAARIGINREVLRLLVQRKILTRVARGVYVQTSALEQAAHAADRHVLRARPLLRSRPADWAASHLTATLLWDLPVPEVDLARLHVCHAQPVGTSRRRAAYTVHLCPGSERIVVHEGLRVVAPATALVGTAMKVATGPAVAAIDAGLQRRQVTRAELEAELDRAARVPQVVAARLAMGRADGRSESPGESLLRLILVDLGLTVIPQYPVRDGDVVIARVDFYLPELGVVLEFDGRLKYDGHEGRDALVAEKIREDRIRSLGYGVGRLTWGSLRQPVAVSRVVADAARAARPHVIVARAS
>NZ_CP042862.1|WP_010146567.1|1933820_1934579_+|ROK-family-protein
MAKKHVLGIDIGGSGIKGAPVDLDKGEFATERERIPTPEESTPEAVAEVVAQIVEHFGGDIAKGSPIGITVPAVVHHGVVRTAANIDPSWIGTDADTLFTERVGRSVHVMNDADAAGVAEMHYGAGRGNEGVVLLTTLGTGIGTAMFMGGELLPNTELGHLEIDGHDAETRAASSAREREELSWEDWAERLQRYYSHVEDLLWPDLIIVGGGVSKKAEKFLPLLHTRAPIVPAQLKNDAGIIGAAWQAQHLG
>NZ_CP042862.1|WP_010146568.1|1932890_1933751_+|type-I-methionyl-aminopeptidase
MPTLTPIAPGRVSPRRPVPASIARPEYVDRPSPKPFRGSEVKDAQTIEAMRAAGRLAAQALALCGEMVRPGVTTDEIDRVGHEFLLDHGAYPSTLGYRGFPKSLCTSINEVICHGIPDDRELREGDICNIDITAYLGGVHGDNNATFLVGEVDEQTRLLVERTEEALARAIRATRPGREINVIGRVIESYASRFGYGVVRDYTGHGVGEAFHSGLVVPHYDAAPDYSTIIEPGMTFTIEPMLNLGTPDWTEWDDGWTVLTADGRPSAQFEHTLLITDDGAEILTLP
>NZ_CP042862.1|WP_033228590.1|1932615_1932825_-|hypothetical-protein
MQYWYNTKTGQVESEIDEQRARSADLLGPYGSADEATRALEIAREKTKRWDEQEQDEDNWDNNPLNDKD
>NZ_CP042862.1|WP_010146571.1|1931591_1932593_+|TIGR03557-family-F420-dependent-LLM-class-oxidoreductase
MSELTVGYAAMLEQFHPSEAVALTAAAEEHGFSGCMAADHFAPWVPHQGQSAFVWNVLTAVGERTTGDLGPGVVCPSFRWHPAVVAQAAATLEAMYPGRTWLGVGAGEALNEHVLGGYWPEAGERSRRMFEAVELITQLFTASAAGKDTKFAGEFFRMETTRLWTMPETAPEILVATAGPINARKTGQLADGIITVGAPPEKIEMLLGKFADGARQAGKDPDTMPKVLQLHLSWAPTDEEALANAMTEWPNGGMKFGKADIRSPHDFAAMAQLVRPEDFEGRMVISSDPDVHRAHIQSLLDLGFDRVYLHNVGRNQQEWLEVFGREVLPALHR
>NZ_CP042862.1|WP_010146572.1|1931190_1931538_-|MGMT-family-protein
MDEVVVEKVLRAVEQVPPGRVVSYGDVAAVVGIGPRQVGSIMRHWGSNVTWWRVTNAQGDLPVEVLARARPHWREEGIELRPGAPGCRIATYRADLEQLGHDYARATRDLPHAAG
>NZ_CP042862.1|WP_010146573.1|1929857_1931186_-|glutamine-synthetase
MNRQQEYVLRTIEERDIRFVRLWFTDLMGTLKSVAVAPAELEQAFTEGIGIDGSVIEGFTRVYEADMIVQPDADTFQVLPWRDRTARMFCDINMPDGTPAATDSRNILRRTLDVAGEQGFTFYTHPEIEFYLFKEPYDRTVGPTPVDQAGYFDHVARGDGHDFRRAAIEMLEQMGISVEFSHHEGGPGQQEIDLRYADALSMADNIMTFRTVVREVALHEKAFATFMPKPLAGHPGSGMHTHVSLFEGDSNAFYEPGANYELSQTGRRFMAGVLMHSREICAVTNQWVNSYKRLWGGGEAPAHVCWGHNNRSALARVPMYSIGKGHSRRIEVRSIDAACNPYLTYALILASGLKGIKEGYDLPPEAEDDVWVLTDAERRAMGIDPLPQSLGEAVAVMEESELVADVLGEQVFDFYLRNKWQEWGDYRSQVTQFELDRYLLHL
>NZ_CP042862.1|WP_141567498.1|1926540_1929741_-|bifunctional-[glutamine-synthetase]-adenylyltransferase/[glutamine-synthetase]-adenylyl-L-tyrosine-phosphorylase
MARGGFEDSRRAGQLLTEVLERLAPAGEGEGGSEVDTADLVADLGSSADPDAALLLLVRLLDPRSTGARGERTDALTLPVVRAGGAPRRRLLALLGGSVALGESLLRHPEHIEDVAEGGSPEAWAIVEAVRGQEGRAGADALRVAYRRQLLRVATADLTSDDPVALLPAVGGALADLASAALEGALLLARAEVPGEEQCDLAIVGMGKTGGRELNYLSDVDVIFLAAPRQGEEESQALAVGARLASAVMRICGESSAEGSLWQVDAALRPEGRHGPLVRSLASHREYYQRWAKTWEFQALLKARVVAGDGDLGRRWLEIVEPLVWEAAGRDNFVDDVQSMRRRVEQHVKREEVDRQIKLGPGGLRDIEFSVQLLQLVHGRADSGLRSRTTLEALAALRDGGYVGREDAHALDEAYRLLRCLEHRVQLHRMKRTHLMPTGEADLRRLGRALGERGEADKAVLTRWKGVRREVRRLHERLFYRPLLSAVARLSSDEARLSPEAARERLAALGFRDPAGAMRHLEALTEGVSRRATIQRHLLPVMLSWFADGADPDAGLLAFRQISDALGTTHWYLGMLRDEGSAAQRLARVLSSSRYAVDLLIRSPETVALLGDEGELMTPDKDALVARMTAAAVRQESAEEAFASVRSVRARELVRIVLGDLAAGWEGPQVRQALSDLTDAYLEGALGVATRRVLARRGEEAAAAVLVVGMGRLGGREVGYASDADVMYVYDTLPGADPERAAEQATAIITELRKGLTGTGPDPVLELDAALRPEGKAGPLVRSLEGYRSYYERWSAGWESQALLRARPVAGDPALGEAFTEMIRPLRWPEGGIEDSAVREIRTLKARMEAERLPRGADPRTHLKLGLGGLSDVEWVAQLLQLRHAHDHPGLRTTSTIDALRAAGDAGLLSEQDRAPLLEAWSVASQLRDAGIVWRGRPVDSVPSNLRDAEGMSRVMRRGPGSGASLAQDWRRTARHSREVVERLLYGNRPPRTGVEGEPAQRQARPGAPGRRPDAPSRDRRTDGFGRPRVASPPRAADHYPPPRRDPFGRSERRRRGEGGAGPAGP
>NZ_CP042862.1|WP_010146575.1|1925885_1926530_-|hypothetical-protein
MSPADDPTPSGRSQGLVLAAGPRPEVDTWVAASIVPVTVVPLQGWVAVVTRGPSRAGSPYDDGGLVNACRALSARAAPGLGFFEIDGRALVTVHAPGRRRRVRWVVWEPEQGLLRPPGLELAGPSELVRLAGAEAPVRDELVDLLHETRVRPARMLQAVMATLGLPGTRLLDDPAHADTLPGAVRRDPDPQQVEWFEDAVRDSVRLRRELGVLS
>NZ_CP042862.1|WP_010146576.1|1925181_1925889_-|phosphoribosyl-isomerase-A
MTGTLDLLPAVDVASGRAAQVDADLPARPLDVAQAFVDQGARRIHLVDLDRAFGRGGDPRLMELLVEQLPVPVQLSGGITGPEDLAWAARTGAARVVLASSALASRDVLERAVDLLGERLVVAVDVREGQVVARGTPLVLGTLETVLAGHAVLREGHVRVLVADASRDGRRTGADLSLFRSVAQLVGAPVTASGGVAVLDDLGALRDCQEVDEVVLGAALHDGAFTLAQALEVTA
>NZ_CP042862.1|WP_010146564.1|1937426_1938098_+|MBL-fold-metallo-hydrolase
MQITHLGHACLLVEVGDQRILIDPGSFSSFEDVDGLTAVVVTHQHADHLDPERGGALLAANPEARVLMEAETAATVADSGYADRVEVLGAGSTVELGSGEGAVTLTGVGERHADNHPYVPRVGNTGVVVRAAGEPVLYHPGDALDGEPGEVDLLAVPVSAPWGKVAEAIAFVRRLAPARGIVPIHDGLLNDRGRAMYLTHIGDFGAEGGVEVLDLRGAGATTV
>NZ_CP042862.1|WP_051125096.1|1938114_1939233_-|VIT1/CCC1-transporter-family-protein
MGHVPWLYVTPQHPAPTDVRRWRRHLADEHANIRAFRDLAARRQGEEQSILLSLAQAEERHAQHWVQLLGERAEPAPRATLGHRVQTWLARRFGLVFVLALLQRSKSDNQYADERDAASSMAADEQVHEEVLRGLAARGRLQLSGNFRAAVFGANDGLVSNLALIMGMAGTGVSAAVVLAAGMAGLLAGALSMGAGEYISVRSARELLAASQPAHGTRDALGDLDLQTNELELVYRARGMDKDHARARAADVLGQVQQAGTAPDDAVPAAATEADEQDAVLNPWGAAVSSFGFFASGALIPVLPYLFGMTGLAAAGLAMLLVGLALLVTGGVVGVLSGASPLGRGVRQLLIGYGAAIATYLLGLAFGAAGIG
>NZ_CP042862.1|WP_010146562.1|1939761_1940655_-|HAD-family-hydrolase
MTSVGARGSGEGDTPWGSSREALRGRAARTPRRVVASDCDGTLLRTDGTVSAYTRDVLARCAAAGVTVVLVTARPPRWMDELADLGVEALALCGNGAFTYDIARREIVSHRLMSADLVGQLLIDLKAAMPQAALATESLRGFAREPHFHRADDRADGQWLVGGLEDLAQEPAGKILVRHLDWSTEQISARVAEVVGERAEVANSGAIQMGEVTGRGVTKALALSTWCAEQPEPVSPEEVWAFGDMLNDLPMLAWAGRAHAVANAHAEVLALADEVVPSNDEDGVARTLERLLEQTSV
>NZ_CP042862.1|WP_010146561.1|1940651_1942121_-|RNB-domain-containing-ribonuclease
MVERATSLACDPSASETGRLLTQAFQTIRDDLEVRQAFPEAALAEIEQAVADPELPERDETDVEFVTIDPPGSMDLDQAMHISRDGAGFRVRYAIADVPAFLHEGGALDAETRLRGQTIYCPDTRVPLHPPALSEEAASLLPDAVRPAYVWDIRLTADGERETAELYRAMVRSRRRYTYTEAQELIDGGDAEEALLLLKEVGELRIAREIDRGGASLPMPEQEVGVGTEEDGCDYTLSLRPLLPAEDWNAQISLLTGMVAARIMLDGGVGILRTMPEPTEGAVARFRREVEALGAQWPEGMPYGEFLRTLDRTDTRHLAIVNAATFLFRGAGYTAFDGELPPEDEQVQSAIAAPYAHVTAPLRRLVDRFGLAVCEALSAGREVPDWARAALPDLPDVMEETGRRAKAVDRACVTAVEAAVLRDRVGEDFEAVVVDGVDGDRVQVQLMDPPVSDVATGSARLGSAITVRVERADILAGEVDLRIVGRDEQ
>NZ_CP042862.1|WP_010146560.1|1942169_1942928_+|peroxide-stress-protein-YaaA
MLILLPPSESKQTRARGAALRPETLSSPGLTAARDQVATALAQVSERPDAPGVLGVSPNLTEEIARNTRLWTAPTLPARDLYSGVLYDALDLPSLDPGAARRATSRLRVVSALYGVARMTDRLAPYRLSMGVNLPGVGPLAGFWKPLLDPVLTAAAGRGLVVDCRSSTYAAAWVPAPSSEVAARWVHVRVPGATHMAKHTRGLVARALCEQPSDPRRPQALVDLLADRFEVALHEPTRDGAPWILDALPRHP
>NZ_CP042862.1|WP_010146559.1|1943053_1943992_-|class-I-SAM-dependent-methyltransferase
MDVQPVALTPMERARMTPEEGYALNRDNWDGRALVHAASSDYDLDGLVGDPTRLSTVIRDDLQILRPHLPEGLRDGGDGLPRLDGLDVCHLQCHLGTDTLSLARRGGRCTGVDLSPESLRIARDVAARAGQEIRYVEANVLDAAAAVGAEVDHVHTSIGTICRVQDLATWGRQIAALLRPGGTFFFRDSHPMLNVMDDTDPEIMTPGYGYFPLPVGESFTYADGQTYTDGDAAAITQPRNAEWSHSVSEILGALIDAGLRIEHVGEHQHLPWPAHPAMTLEDEGFVLPEPWRSQVPVALSIVARREPGPTTG
>NZ_CP042862.1|WP_158640866.1|1944207_1944888_-|histidine-phosphatase-family-protein
MAETYLSDETVPVLEGSTRLVIVRHGVTDFTVAHRMDGRGGADPALNAAGRAQAAAAAEAVAELLARSTTGEVRVVSSSLRRAQETGEALAQRLGVEREQDRDWDEQAFGDWDGRSLPALAAEVPEEVAALRTDRDYARPGGESRRDLDHRVGAALGRAVALGGTVVVATHRVAIMSVLCRVLGVDHERGWSIATGPASLSAVEFWPDGGVQVAFVNDTHHLLHLA
>NZ_CP042862.1|WP_010146556.1|1945079_1945817_-|hypothetical-protein
MKASPQMQARLLELQELDTRIAQLEHRLASLPEQIDITRMEREQPALEADVVRTSTEVSDLEREVGKAESAVQLVRDRAARDQERLDAGSGTAKSLQGLQHELESLARRQGVLEDAELEVMERLEQAQAGQEAATAAQQKHEGRLAELRAARDEKAATIGAERDEVAAGRAAIVADVSAELLALYERLRAHSGSGAAPLQQRRCGGCRLELNTVDLNRIKAAAEDEVVRCEECGRILVRTAESGL
>NZ_CP042862.1|WP_010146555.1|1945813_1946713_-|Nif3-like-dinuclear-metal-center-hexameric-protein
MNVSTPQAGVPLADVVAALEELYPPETAQSWDRVGLVAGDPEQTVRRILLAVDPTLEVVREAVREGADLVVTHHPLLLRGIHSVATTSAKGATITELVVNDVALYCAHTNADVADPGVGQALAAACGLAATEALTISEEQELGRVGELAEPVTLRALAERLGDALPATAGGVRVSGDPEALVRRVAVLGGAGDGEFAAVRRAGADVYVTADLRHHPALEAREEARAAARAGGAATPYLIDAGHYASESLWLPGLRELLTSRLDVEVEISAVRTDPWDFVIGALAPQDPTTDHPVEGDRP
>NZ_CP042862.1|WP_033228586.1|1946806_1947274_-|peroxiredoxin
MREASPEVGGRAPELALVDQAGELHTLSTVVADRHALLVFYPFAFSSICTGELLEIQLNIDEFVNDRVQVYGISCDPAPALRAWAAHEGYRFPLLSDFWPHGQVARDYGVFDEDSGMAVRGTFLVDPTMTVRWSLVQGPGEAREIGALHEAVRDL

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Crispr_ID: NZ_CP042862_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_6

3075417-3075557

Orphan

Consensus_repeat	Method
ACCCCACCGAGCGCCGCAGATGGCTCCCCCTGACCCCACCGAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042862_6

>merge|NZ_CP042862|6|3075417-3075557|CRISPRCasFinder
ACCCCACCGAGCGCCGCAGATGGCTCCCCCTGACCCCACCGAGCGCCGAGGATGGTCGCCCCTGACCCCACCGAGCGCCGAGGATGGTCGCCCCTGACCCCACCGAGCGCCGCAGATGGCTCCCCCTGACCCGACCGAGCG

>NZ_CP042862|6|6|3075417-3075557|CRISPRCasFinder
ACCCCACCGAGCGCCGCAGATGGCTCCCCCTGACCCCACCGAGCG	CCGAGGATGGTCGCCCCTGACCCCACCGAGCGCCGAGGATGGTCGCCCCTG
ACCCCACCGAGCGCCGCAGATGGCTCCCCCTGACCCGACCGAGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_010146188.1\|3091562_3092276_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP042862.1\|WP_029540642.1\|3066952_3068116_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP042862.1\|WP_010147194.1\|3071809_3072715_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|181022
NZ_CP042862.1\|WP_051125073.1\|3088056_3090561_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_CP042862.1\|WP_033228458.1\|3075666_3076518_-\|methylenetetrahydrofolate-reductase	unknown	unknown	gnl\|CDD\|238299
NZ_CP042862.1\|WP_010147191.1\|3068819_3070259_-\|trimethylamine-methyltransferase-family-protein	unknown	unknown	gnl\|CDD\|368818
NZ_CP042862.1\|WP_010146180.1\|3078078_3081609_+\|exodeoxyribonuclease-V-subunit-gamma	unknown	unknown	gnl\|CDD\|273633
NZ_CP042862.1\|WP_158640888.1\|3077717_3077987_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|377904
NZ_CP042862.1\|WP_010146177.1\|3076606_3077299_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP042862.1\|WP_010146181.1\|3081605_3085037_+\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273172
NZ_CP042862.1\|WP_158640889.1\|3092272_3093646_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP042862.1\|WP_010147193.1\|3071135_3071813_+\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|239021
NZ_CP042862.1\|WP_010147190.1\|3068288_3068660_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP042862.1\|WP_010146178.1\|3077322_3077721_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350219
NZ_CP042862.1\|WP_010146187.1\|3090560_3091343_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP042862.1\|WP_141567570.1\|3072657_3074709_+\|DUF4445-domain-containing-protein	unknown	unknown	gnl\|CDD\|226410
NZ_CP042862.1\|WP_010147188.1\|3066450_3066843_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226318
NZ_CP042862.1\|WP_141567571.1\|3074638_3075409_+\|DUF1638-domain-containing-protein	unknown	unknown	gnl\|CDD\|377918
NZ_CP042862.1\|WP_010147192.1\|3070380_3071139_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP042862.1\|WP_141567568.1\|3065168_3066464_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|227277

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_010146188.1\|3091562_3092276_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.35087e-70
NZ_CP042862.1\|WP_029540642.1\|3066952_3068116_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	3.98413e-06
NZ_CP042862.1\|WP_010147194.1\|3071809_3072715_+\|dihydropteroate-synthase	gnl\|CDD\|181022	PRK07535, PRK07535, methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated.	4.79994e-98
NZ_CP042862.1\|WP_051125073.1\|3088056_3090561_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	8.00301e-18
NZ_CP042862.1\|WP_033228458.1\|3075666_3076518_-\|methylenetetrahydrofolate-reductase	gnl\|CDD\|238299	cd00537, MTHFR, Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase to convert homocysteine to methionine. The enzymatic mechanism is a ping-pong bi-bi mechanism, in which NAD(P)+ release precedes the binding of methylenetetrahydrofolate and the acceptor is free FAD. The family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from prokaryotes and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The bacterial enzyme is a homotetramer and NADH is the preferred reductant while the eukaryotic enzyme is a homodimer and NADPH is the preferred reductant. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease.	1.76767e-25
NZ_CP042862.1\|WP_010147191.1\|3068819_3070259_-\|trimethylamine-methyltransferase-family-protein	gnl\|CDD\|368818	pfam06253, MTTB, Trimethylamine methyltransferase (MTTB). This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.	0
NZ_CP042862.1\|WP_010146180.1\|3078078_3081609_+\|exodeoxyribonuclease-V-subunit-gamma	gnl\|CDD\|273633	TIGR01450, recC, exodeoxyribonuclease V, gamma subunit. This model describes the gamma subunit of exodeoxyribonuclease V. Species containing this protein should also have the alpha (TIGR01447) and beta (TIGR00609) subunits. Candidates from Borrelia and from the Chlamydias differ dramatically and score between trusted and noise cutoffs. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP042862.1\|WP_158640888.1\|3077717_3077987_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|377904	pfam07704, PSK_trans_fac, Rv0623-like transcription factor. This entry represents the Rv0623-like family of transcription factors associated with the PSK operon.	4.17293e-12
NZ_CP042862.1\|WP_010146177.1\|3076606_3077299_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.04638e-50
NZ_CP042862.1\|WP_010146181.1\|3081605_3085037_+\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|273172	TIGR00609, RecBCD_enzyme_subunit_RecB, exodeoxyribonuclease V, beta subunit. The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP042862.1\|WP_158640889.1\|3092272_3093646_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.56795e-38
NZ_CP042862.1\|WP_010147193.1\|3071135_3071813_+\|cobalamin-binding-protein	gnl\|CDD\|239021	cd02070, corrinoid_protein_B12-BD, B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or monomethylamine, which is initiated by a series of corrinoid-dependent methyltransferases.	5.13308e-82
NZ_CP042862.1\|WP_010147190.1\|3068288_3068660_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000704184
NZ_CP042862.1\|WP_010146178.1\|3077322_3077721_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350219	cd09871, PIN_MtVapC28-VapC30-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC28 and 30 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC28 and VapC30 toxins. M. tuberculosis VapC28 and VapC30 both cleave tRNA25Ser-TGA and tRNA28Ser-CGA. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.28255e-51
NZ_CP042862.1\|WP_010146187.1\|3090560_3091343_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.3122e-105
NZ_CP042862.1\|WP_141567570.1\|3072657_3074709_+\|DUF4445-domain-containing-protein	gnl\|CDD\|226410	COG3894, COG3894, Uncharacterized metal-binding protein [General function prediction only].	6.58215e-106
NZ_CP042862.1\|WP_010147188.1\|3066450_3066843_-\|hypothetical-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	6.25274e-17
NZ_CP042862.1\|WP_141567571.1\|3074638_3075409_+\|DUF1638-domain-containing-protein	gnl\|CDD\|377918	pfam07796, DUF1638, Protein of unknown function (DUF1638). This family contains sequences covering an approximately 270 amino acid stretch of a group of hypothetical proteins. These proteins are expressed by archaeal species of the Methanosarcina genus.	2.93176e-31
NZ_CP042862.1\|WP_010147192.1\|3070380_3071139_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.01373e-44
NZ_CP042862.1\|WP_141567568.1\|3065168_3066464_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	8.47183e-99

>NZ_CP042862.1|WP_141567571.1|3074638_3075409_+|DUF1638-domain-containing-protein
MSSSRTAATSTTASSTNSPSPRPDSSIAATDRRRGPDALPLRVEGARVALVACGALATHAAAAAARHTPALPVDVHPLPPLLHNHPARIAAEVEAVIDRLAGRYDRVIVGYADCGTYGALDELCARRGVARLPGLHCYDLYAGEARIAQLMEEEPGTYLLTDFLVRSFDRTVWAELGLDRHPELRDDYFGHYTRCVWLTQEPEPDAELTTQAEAEADLTRAAQRAAALLGLPLQLETTGLTGLDDALARLVLADDA
>NZ_CP042862.1|WP_141567570.1|3072657_3074709_+|DUF4445-domain-containing-protein
MGYVVDRRPPRAAGGRGDVRQPQAGAGTAQGAVIRAAGAAAELDDASGSVAETTPERVDLTYTPSGTTVRVPSGVNLFEAASWNGIAVDSTCGGHGTCRKCKIQVTEGERPPVLPQDERTFSPGQLEAGWRLGCLALARSSLTVDVPPLTTRPKASTVGVGRQVILRPSVQKRYVELEEPTLADQRPDLARLLDAIEDLEPTPELHALRRVGTALRAADYRVTAVVADDRLIDVEEGDTTGRSFGIAVDLGTTTVVATLMDLTTGTPVAVASMLNAQQPFGGDVISRISATMLDPQALPRLRVRAHETLAELAAEVCAEAGVEPREVYDVAIAGNATMVALLLGQDPEPLGVAPFILATHRWPLVPAGEVGLGEAVHPAAKAFLHPALGAYVGGDIVAGIQASGMDRDSRVRLMIDIGTNCEIVLSDGTQLVSTAAPAGPAFEGASIRCGMRAADGAIETVKLLAEWPEPADGDEPLPDPVQLGVIGDVEPRGLCGSGLVDAVAELSRVGLLDSSGRLLDAEAARAVAPALADRLASVGDAGERVFVLHRESPDLPAAESVYLSQRDVRELQFAKAAISTGWTLLLEEVGLEPREVQQVLLAGSFGSYLSPAAAVRIGLVPKLPTLRIVAAGNIAGEGAKMVLLSATERTGADALLEGVRYVELSDRSDFNDRFVDQLAFPST
>NZ_CP042862.1|WP_010147194.1|3071809_3072715_+|dihydropteroate-synthase
MSPAWGSAALAGGPLHTVLRSATAEVVIGSDQKFCVIGERINPTGRKTFQLQLREGDLSAIEKDIEAQVAGGADVLDVNMGVPLTDEADLLVRAIQLVQARCDLPVCIDSSVIEALEAGLEAYQGRALVNSVTAEDERLEAILPLVKKHGAAVIALPNDADEIPMESGKRLELVEKIVRVATQEYGIAIEDIVIDPLAMPIGADSTVGITTLETIAGVHERWGLNMTCGASNVSFGMPGRHAINGAWLPLAMAAGMTSAIMDARTPEVVGAVRAADLLLGHDEWGMSWIGAHRARQAAAAT
>NZ_CP042862.1|WP_010147193.1|3071135_3071813_+|cobalamin-binding-protein
MTPDEILQGLYDRTLVGNGPGVLELTHEALGMEMEPQVLLFDALIPALEEVGARFERGDFFVPEMLIAGKAMAGSMEVLRPLLADTGVQTVGTFLMGTVKGDVHDIGKNLVNIMLEGAGFEVIDLGVQVAPEKFVAAIEEHQPDVVGFSAFLTTTMPMFKANMNALEKAGIRDDVIVMVGGAPVTQEYADAVGADGYAADASATVKKAKTLLKDRRARAGAAVPV
>NZ_CP042862.1|WP_010147192.1|3070380_3071139_+|IclR-family-transcriptional-regulator
MATQGTQAIDRAADLVVRVVQSPDPLSTPELAQATGLARSTVSRLLAALERSHLISRDVEGHGYLPGPLFEQYAARTDTREWLAREAHSTMAALSDATGETINLGVPVGGAVVQIAQVDSTFMIGSRNWVGVDLPAHSSSLGKTLYAFGALDLPAQLEALTERTVTDPDTLRAEFEVIRRRGWATTVDELEVALTGIGAPVRLRGRLVAALGVSGPTSRLSGRLDELGRLVSRHADDLSARLTEPHMMKGAS
>NZ_CP042862.1|WP_010147191.1|3068819_3070259_-|trimethylamine-methyltransferase-family-protein
MFVNRMPRYEVLSEQAMEQLDGAWRRLMTEVGVQFASEEALELFRQAGQKVEGETAYLDPEWVLEQVAKAPHEFDVQARNPERSVHIGGDSMAFGAVYGPPFVREGEARRDGTFDDFQRFARLAQTFDVLDSAGGVVCEPNDLPLDSRHLDMTLALMTQTDKIYMGNVVTGENARDVIAMGEILFGGREAIEQTPASISLINCNSPLRWDDRMLESLFEYARAAQPVVLTPFILMGAMSPVTIPAALTQQITEALSGIALAQTIRPGTPVIFGSFLSTIDMQSGSPTFGTPESGLGLLCTGQIARHFGLPFRGGGGLTSSQVPDAQAGYEATMTLLPTFLAGTNWVMHSAGWLEGGLVSSFEKFVVDCQILEMLQHEFKPLEIDEGSLAFDAHVEVGHGGHFLGAMHTMERFRTCFYRPFLSSADNFERWSGKGSPDTATRAGAVVASRLEAYEAPPLDPAVKEELEAYVVRRRAELGD
>NZ_CP042862.1|WP_010147190.1|3068288_3068660_-|nuclear-transport-factor-2-family-protein
MDTVALVRTLIETIDDRRWGDLPSLLAPDVRIRLVHTGETFDRESWVRFNADYPGFGRMWLEDVVGVGERAAARVHTTGTVDGQEAHFEVAMFVTAREGVIVELVEVWADCDAEPPVGTRTSG
>NZ_CP042862.1|WP_029540642.1|3066952_3068116_-|exo-alpha-sialidase
MRTRPSLLVGTTKGAFILDSGAEGAWSVRGPFCDGWPINHVVGDPATGTLWAGGGGDWTGAGVWRSTDGGHSWTLAKLSTGQMDAWASKDPEFAAMVGWTQGQEPFGAEFSQVWSLGVAGDRVYAGTKPAALLASDDGGVTWAEVESLRKHPSAQEWNPGAAGLVLHTVLADPGDPTRLWLGISAAGVFASKDAGGQWERRNSLALAEEPDAGAMADHPGGPGGGEVGLCVHHIVRAPGPGDVLYQRNHVGVWRSGDGGLTWTDITAGLPSTFGFPMRVHPRDPDTIWTIPLNGDMEGRYPPDAAAAVWRSTDGGSTWEAQRDGLPQEACFFTVLRQAMAGDTGDPAGLYFGTNTGSVFASPDEGESWAEIARHLPTVLSVETLEVG
>NZ_CP042862.1|WP_010147188.1|3066450_3066843_-|hypothetical-protein
MKYVILIQSNPQPWGHPTSDFLPGAQDQTQQERDASEADFGRLLTEISSSGELVTAEALGDPAASRLLRWRDGERVITDGPYAEGKEHLAGFFLIDVDSQERAEQIAGGFGAPGETIELRPVMGGGGDVD
>NZ_CP042862.1|WP_141567568.1|3065168_3066464_-|sigma-70-family-RNA-polymerase-sigma-factor
MTSTESPGAQPVEPSSAAARAVEEVWRTERPHVLAALSRRHTDAADVEDAAQQALIAALEQWPREGVPDAPRGWLIRVASRRLTDQMRADGARRRREEVVARQDHAVHRGAEGWPADLEVEQTPALDDLLDQMLRCCHPALSPSSRVALTLRAVGGLSTREIAAGFLVPEATMAQRISRARATLVQRVAGFGPTPPAELPERLAAVRHVVSLVFTEGHQRSSGDAVIGRAFVEEAVRLARLLHRVAPQDPETAGLLSLLLLTHARSPARVDARGDLVPLDRQDRHLWDAALIREGVQLLEVCLPVGEVGAFQLQAAVAAVHAEAATAQDTDWPQILALYRMLDAVAPSAATTLALATASAEVDGPHVGLALLDELEEERWHRVHAVRGHLLQRLEDRPGARASFATAARLTRSIPEQRYLNARIRELDDGA
>NZ_CP042862.1|WP_033228458.1|3075666_3076518_-|methylenetetrahydrofolate-reductase
MSNKCPSVALEGLLRGARLEILPTGSIAEQVHAHVEPGRTVTVTASPAKGLEATLALTEELADRYHVVPHLAARMVGRAELPDIVARLRAAGVTEIFVPGGDATPTETAFTNALDLLIELEELGRPFERVGITGYPESHPGIDDDVIVQSMWDKRRYATDIVSNMTFDDEQVGRWLERIRRRGIEQPVWIGVPGPVDPAKLLKMATVIGVGDSMRFLRKQHGVFTRIALPGFTTTRFAHRVAALAGTERLGIGGLHLYSFNQVEKTEAWRREQLSRAADLRRP
>NZ_CP042862.1|WP_010146177.1|3076606_3077299_-|dienelactone-hydrolase-family-protein
MPTEDVFTLPRPDGDLPVHRFRPDDPAHAGIVLVQEIFGVSPYIRDRARDLAEAGYEVHVPELYWRIPDHEVDGSGEQMLQHGMELMGRTDWDGAVEDTVTAVEHLRGAVEGRVGLVGFCYGGGVAFAAAAQTSVDALVSYYGSALPGLLDLAPQVTAPSLHHWGTDDAFIPRETVEEIERAVARDGVEFVWHDGAGHAFDNPLPAFFHAEASAAAWPRTLTFLGRHLRG
>NZ_CP042862.1|WP_010146178.1|3077322_3077721_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MIIDSSAVMAVLQQEPGAEDLLRVLAASPSRISAATLVEVGIVADARSTAHGERLDHLLDVLEITVVPVSARQAQVARLAYRRFGRGSGSPARLNFGDCFSYALAVEAGEPLLFVGSDFTHTDIAAAPRSRA
>NZ_CP042862.1|WP_158640888.1|3077717_3077987_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MSLNIKNDRVHALAREAARITGRSQTSVIEEALTRLLADYGADPSTVSQGRKLDLAHQILAEYAADPGLAGRAIREPDDLYDELTGLPR
>NZ_CP042862.1|WP_010146180.1|3078078_3081609_+|exodeoxyribonuclease-V-subunit-gamma
MTLFVHRDTSTAKLADGLADLLATPLPDPFAQEVVAVPAKGVERWLAQRLSHTLGAGTSGHDGVCAGVRFLNPHSLVAMVLGIERDDPWHPDRLVWPVLEAIDGSLSETWATTLATHLGYDASGAEGELRRGRRYAVARRLAGLFAAYAGSRPAMLTDWREGGDGDGLGSPVDADLAWQPPLWRRVLARVDAEPPDVRQARVVQALRSGTHAGPGGELDLPGRLSLFGHTRIARSEVEVISALAEHRDVHLWLPQASPTAWDALAEDARSGPVPREDDMSALLIDHPLLASLGRDARELQRTLALAPHTLLRSDAAPATTTPARPAAPGPGQTSLLHLLQADLAADHPPTDAERAARAIPEAERSLQVHACHGQSRQIEVLRDVLADLLQHDPTLEPRDILVMCPDIDAYAPLVHAGFGLGEVGRERDAGGVGGSIPTHPAHSLRVRLADRAPTQANPLLGLAARLVELAGGRLTAGEVLDLARTAPVRRRFGLDDDDLERLGDWVGSVAIRWGLDDAHRGDYALPGLTQNTWQAGLARVLVGAAVDGQEVDHLGTTLGLDDLDSADLDLAGRMAELVARLGGTLRALRSATAVPEWVEALTDGVLGLADVAPADAWQVTQLRRELDLVGVHASAPATEGGDLALSLSDVRALLEEHAAGRATRSNFRTGTLTVCTMVPMRSVPHRVVALVGLDDGVFPRTTAPDGDDATARRPVTGERDPRSEDRQLLLDAVMAASDALVITYTGFDEHTGAPRPPAVPLGELLDAVRRTADPDSPGVCRVLTEHPLQPFDPRNLGASREGARALLPGGAPFSFDPAALAGGRAAVAPRTPRPLPVDASLGPLAPAEAESVALDALLRFFDNPARAYLRDRLGLVLPEVPEEQGEGIPIDLGGLETWAIGDRVLQAVLAGRDPGATVDAELWRGELPPRALGATVMGEVTKQAQLVAEATWSTVGQGGWGIPLDRDTLDIDLTLPSGVRLTGTLTGLVGHRAVKATYSTIKAKQRLQSWITSLVLAAALGPEASSHLFGRQRRGRKPGGVHFTHGPHDPDQALGLLDQLVDVRARGMVEPLPLPVQTALRWAESYLGGPGDARAATLDAVREWRTDDTFEQAFPKEQDDPSHSYVFGVSAPLQDILGVAREDERWEPGVEHRLGQLALRVWGPVLRGGAERRQSV
>NZ_CP042862.1|WP_010146181.1|3081605_3085037_+|UvrD-helicase-domain-containing-protein
MTIPHFSITDPLPSGTVLLEASAGTGKTWTIAALVTRYVAEGVVLLPEMLVVTFGRAASQELRARVREQLVAAERALSDPPPLEQRDDLVTLLLDVDDQERETRRRRLRTALSDIDAATIATTHQFCQQVLRSLGVAGTADAGAELVDDLDRLLVEVVDDLYLRAFALRDDEPFFTRREALQIARTVVDDIHADLRPTAAEPGSVPGRRVRFAQAVRAELDLRKQRLQVMHYNDLLTQLADALERDDSPARARMRGRWKVVLVDEFQDTDPIQWSVLDRAFTGQAHAMVLIGDPKQAIYAFRGGDVPTYLTAAATADDRRTLPRNFRSDPGLTQALGSMLTGAQLGDEQIVVHPVTAHRTDSRLTGAPSSAPVRVRQVLLRDHLGGDTRMPTVRPWIARDLAHDVAALLASGATFDDRPIQARDVAVLAHRAKDLLEAQSALRELGIPAVSTGGSSVLASRAAHEWLALLEAMVAPHRPMLTRAAALTDLLGYAVAQVGARGEREDTELEDALAQTCRELAGVYARHGVAAVLELLTARGLPARVLSQVGGERSLTDLRHVAQLLHETARHDQLGLVALLEWLRAGMAEDSPQSAGARTRRLDSDAAAVQLATIHGSKGLQYPVVYLPSLGDRWVSDSPAIPLFHDDPPERTRCLDVGGEHPANPGWPESVRRHKEEDAGESLRLLYVALTRAQSQVVTWWAPVNNASDSALHRVLFGREPGQDEVPAKVGVPRQDDVATARLQRWADEGAFVLERADQASEVPLVPSPPAPELALAAWTRRIDHEWRRTSYTALSTPAETEVSVAGVSSEPEVGVTGREDEPSGPDPVIDTVPALPGLDAVAPAPGAEVPSPMADLPVGATFGSLVHAVLEHADPQAPDLAAELRRHIGEQRVLWPVDLGEGGTDLLAEALVAVCDTPLGPLADGTTLREIGTVDRLCELDFELPLGGGDLRRARPGDDAAALLGDLVPLLRSHLPAGDPVRGWADVLDAAPDLAGQQLRGYLTGSIDVVLRVRAGSGDDEGRFLVVDYKTNWLGSPEEPLTAADYRPERLDEAMGHSSYPLQALLYAVVAHRFLRWRLPGYDPARHLGGVLYLYLRGMCGPDTPVVDGMPCGVFSWKPPVALVLGVSDLLDGADRPEGMRS
>NZ_CP042862.1|WP_051125073.1|3088056_3090561_-|FtsX-like-permease-family-protein
MARGWMTAGLASRGRRLVAAAVAIIIGVGFLTASAVILATAQKELEDAVAAGLREADLVLTGESGPVDLEAYDEVAAIEGVSGVTGEASVFTERAGDYFPGTSLPLAGATLLSGELPTGSGEIAVNPAAADDGLALGDTVSITGAPTEGGGRGEAVDVTVVGIVEPGPVHPLTFGLGYVASDPTLRELDPALTYQHVVIELADGADPVAVRDAITGTVPDATLSTGPEAAERAVTAATGGTAVLGAILLGFGGVALLTASLVIANTFTITLAQRTGELALLRCVGATRAQVRRSVVLEALVLGLVTSVVGVLAGVGAGAGLLAVARQLDLGIPMGDGLALGWPSLVLPVVVGVAVTVLASLWPAARATRVSPLAALRPSDLPSEGSRAGLVRIALAVLLLAGGTGLMVMAAISREVLLGVLGGVVSFGGVLLASILVVPWAVRALGLGARVAGVPGRLAVAGAVRNPGRAAATSAALLVGVTLITMTSVGAASGQRTALGEIDKEYAVDLVAEGAPADPGPASGGSEEFLVPSPVDDDLAARLGDVDGVDAAVAVDTAYLRMGESMDPTRAVALDRGAAEQVLRSEDLVDRVEPGIAGLGDTDLAIHGLSAGDELRVSGAEGSRELRVVELGVGGSRLALHPDDLAALAGDSARQGAVLLRLGEQADVVATMTGVSEITDEAGLQLDGAAGLRAQIVQILDVMVLVATALLGVAVVIAVVGIANTLSLSVIERHREHALLRGLGLTRGQMRVMLMVEGVLLALVSAGIGLALGVAYAALGIQTLLPEGTPLALAVPWGRVGIIVAVALLAGALASVLPARRAARVSPAEGLAAA
>NZ_CP042862.1|WP_010146187.1|3090560_3091343_-|ABC-transporter-ATP-binding-protein
MTTTTPQRGSAPTTTRQGSALAASALDLTKTYGRGEAAVTALDGVSVGIEARRFTAIMGPSGSGKSTLMHLLAGLDTPTSGRVHLAEHELSSLSDGQLTRLRRESVGFVFQAFNLLPTLTARQNLRLPLDLAGRDVDAAWERTVVDALGLTERLDHRPGELSGGQQQRVALARALVTRPAVIFADEPTGALDSTTGAEVLALLRRSVDEWGQTVVMVTHDPGAAAVADRVLMLADGQIAGELDHPDADAVLVALRDLGRA
>NZ_CP042862.1|WP_010146188.1|3091562_3092276_-|response-regulator-transcription-factor
MTDAPTRLFLVDDQELVRAGFRMVLDAQDDMTVVGEAGDGQTALEAIAQTRPDVVLMDIRMPRMDGVETTRRLLGEDGRGGAAGPKVLVLTTFDLDEYVYAALKAGASGFLLKDAGPAELLSAIRAVHAGDAAMAPSTTRRLLERFVPELPEAGSEGAAARDRRVAAARLEPLTEREREVLEAVGRGLTNTEIAAELFLAEATVKTHIGRVLAKLGLRDRVQMVITAYQTGLVGRPE
>NZ_CP042862.1|WP_158640889.1|3092272_3093646_-|sensor-histidine-kinase
MRVTTAAAREMAQQVRTWARSTPWLPDVALVAALLLLMVVGGAGLGGPAFLAISLVQIVPLVWRRTHPLPVAVVVAVGCLLQLVLLPGPLTSNIAVLIVIYSAAAFGSPRTSRIVLIMGLAGALIGALRWSAYYGFGSFLSIVAIQATFLACFVGVAWVLGDVMRRRRAVVARLTEQNRALARDQSQRERLAAQDERASIAREMHDVVAHSLAVVVVQADGGLYAARQALSKDPGIAADRAALERAATTLETLADTARASLADTRRLVGVLRDASSGAEYSPLQGLAHLDDLVDRVRSSGVDVQAHVRGDVAALPQDVDLAAYRVVQESLTNAMKHAGPDASVDVDVLRTPEVVLVRVSDDGLGRHGAASDGEGNGLVGMRERVEVVGGTLHAGPRQRRGWEVVATLPVPVGSEVPDAAGADAAGPDAVAPEAAEAPTVAAASYASSDTTRMPEGER

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Crispr_ID: NZ_CP042862_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_7

3091436-3091526

Orphan

Consensus_repeat	Method
GCGTCCCGTGGGAGTCGGCATATCGCACGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042862_7

>merge|NZ_CP042862|7|3091436-3091526|CRISPRCasFinder
GCGTCCCGTGGGAGTCGGCATATCGCACGAGACCCACGGGACGCTCCACCCGTGGCGGGCAGCGTCACGTGGGAGTCGGCATATCGCACGA

>NZ_CP042862|7|7|3091436-3091526|CRISPRCasFinder
GCGTCCCGTGGGAGTCGGCATATCGCACGA	GACCCACGGGACGCTCCACCCGTGGCGGGCA
GCGTCACGTGGGAGTCGGCATATCGCACGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_010146197.1\|3099414_3100737_-\|YjiH-family-protein	unknown	unknown	gnl\|CDD\|225851
NZ_CP042862.1\|WP_051125073.1\|3088056_3090561_-\|FtsX-like-permease-family-protein	unknown	unknown	gnl\|CDD\|226957
NZ_CP042862.1\|WP_033228458.1\|3075666_3076518_-\|methylenetetrahydrofolate-reductase	unknown	unknown	gnl\|CDD\|238299
NZ_CP042862.1\|WP_010146195.1\|3098885_3099308_-\|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274712
NZ_CP042862.1\|WP_010146198.1\|3100733_3102398_-\|urocanate-hydratase	unknown	unknown	gnl\|CDD\|235448
NZ_CP042862.1\|WP_010146191.1\|3095023_3096421_-\|formimidoylglutamate-deiminase	unknown	unknown	gnl\|CDD\|236420
NZ_CP042862.1\|WP_158640888.1\|3077717_3077987_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|377904
NZ_CP042862.1\|WP_010146177.1\|3076606_3077299_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP042862.1\|WP_010146181.1\|3081605_3085037_+\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273172
NZ_CP042862.1\|WP_010146194.1\|3098234_3098777_-\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NZ_CP042862.1\|WP_010146180.1\|3078078_3081609_+\|exodeoxyribonuclease-V-subunit-gamma	unknown	unknown	gnl\|CDD\|273633
NZ_CP042862.1\|WP_010146190.1\|3093729_3094932_-\|imidazolonepropionase	unknown	unknown	gnl\|CDD\|237604
NZ_CP042862.1\|WP_010146187.1\|3090560_3091343_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP042862.1\|WP_010146178.1\|3077322_3077721_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl\|CDD\|350219
NZ_CP042862.1\|WP_010146188.1\|3091562_3092276_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP042862.1\|WP_141567570.1\|3072657_3074709_+\|DUF4445-domain-containing-protein	unknown	unknown	gnl\|CDD\|226410
NZ_CP042862.1\|WP_158640889.1\|3092272_3093646_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP042862.1\|WP_141567571.1\|3074638_3075409_+\|DUF1638-domain-containing-protein	unknown	unknown	gnl\|CDD\|377918
NZ_CP042862.1\|WP_081480442.1\|3096417_3097764_-\|allantoate-amidohydrolase	unknown	unknown	gnl\|CDD\|236456
NZ_CP042862.1\|WP_010146193.1\|3097762_3098245_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367797

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_010146197.1\|3099414_3100737_-\|YjiH-family-protein	gnl\|CDD\|225851	COG3314, COG3314, Uncharacterized protein conserved in bacteria [Function unknown].	1.15529e-119
NZ_CP042862.1\|WP_051125073.1\|3088056_3090561_-\|FtsX-like-permease-family-protein	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	8.00301e-18
NZ_CP042862.1\|WP_033228458.1\|3075666_3076518_-\|methylenetetrahydrofolate-reductase	gnl\|CDD\|238299	cd00537, MTHFR, Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase to convert homocysteine to methionine. The enzymatic mechanism is a ping-pong bi-bi mechanism, in which NAD(P)+ release precedes the binding of methylenetetrahydrofolate and the acceptor is free FAD. The family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from prokaryotes and methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The bacterial enzyme is a homotetramer and NADH is the preferred reductant while the eukaryotic enzyme is a homodimer and NADPH is the preferred reductant. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease.	1.76767e-25
NZ_CP042862.1\|WP_010146195.1\|3098885_3099308_-\|PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|274712	TIGR03666, Rv2061_F420, PPOX class probable F420-dependent enzyme, Rv2061 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	3.19123e-23
NZ_CP042862.1\|WP_010146198.1\|3100733_3102398_-\|urocanate-hydratase	gnl\|CDD\|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	0
NZ_CP042862.1\|WP_010146191.1\|3095023_3096421_-\|formimidoylglutamate-deiminase	gnl\|CDD\|236420	PRK09229, PRK09229, N-formimino-L-glutamate deiminase; Validated.	2.22003e-161
NZ_CP042862.1\|WP_158640888.1\|3077717_3077987_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|377904	pfam07704, PSK_trans_fac, Rv0623-like transcription factor. This entry represents the Rv0623-like family of transcription factors associated with the PSK operon.	4.17293e-12
NZ_CP042862.1\|WP_010146177.1\|3076606_3077299_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.04638e-50
NZ_CP042862.1\|WP_010146181.1\|3081605_3085037_+\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|273172	TIGR00609, RecBCD_enzyme_subunit_RecB, exodeoxyribonuclease V, beta subunit. The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP042862.1\|WP_010146194.1\|3098234_3098777_-\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	3.38983e-26
NZ_CP042862.1\|WP_010146180.1\|3078078_3081609_+\|exodeoxyribonuclease-V-subunit-gamma	gnl\|CDD\|273633	TIGR01450, recC, exodeoxyribonuclease V, gamma subunit. This model describes the gamma subunit of exodeoxyribonuclease V. Species containing this protein should also have the alpha (TIGR01447) and beta (TIGR00609) subunits. Candidates from Borrelia and from the Chlamydias differ dramatically and score between trusted and noise cutoffs. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP042862.1\|WP_010146190.1\|3093729_3094932_-\|imidazolonepropionase	gnl\|CDD\|237604	PRK14085, PRK14085, imidazolonepropionase; Provisional.	0
NZ_CP042862.1\|WP_010146187.1\|3090560_3091343_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.3122e-105
NZ_CP042862.1\|WP_010146178.1\|3077322_3077721_-\|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl\|CDD\|350219	cd09871, PIN_MtVapC28-VapC30-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC28 and 30 and related proteins. This subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC28 and VapC30 toxins. M. tuberculosis VapC28 and VapC30 both cleave tRNA25Ser-TGA and tRNA28Ser-CGA. It belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is a PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.28255e-51
NZ_CP042862.1\|WP_010146188.1\|3091562_3092276_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.35087e-70
NZ_CP042862.1\|WP_141567570.1\|3072657_3074709_+\|DUF4445-domain-containing-protein	gnl\|CDD\|226410	COG3894, COG3894, Uncharacterized metal-binding protein [General function prediction only].	6.58215e-106
NZ_CP042862.1\|WP_158640889.1\|3092272_3093646_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.56795e-38
NZ_CP042862.1\|WP_141567571.1\|3074638_3075409_+\|DUF1638-domain-containing-protein	gnl\|CDD\|377918	pfam07796, DUF1638, Protein of unknown function (DUF1638). This family contains sequences covering an approximately 270 amino acid stretch of a group of hypothetical proteins. These proteins are expressed by archaeal species of the Methanosarcina genus.	2.93176e-31
NZ_CP042862.1\|WP_081480442.1\|3096417_3097764_-\|allantoate-amidohydrolase	gnl\|CDD\|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	1.01941e-158
NZ_CP042862.1\|WP_010146193.1\|3097762_3098245_+\|hypothetical-protein	gnl\|CDD\|367797	pfam04073, tRNA_edit, Aminoacyl-tRNA editing domain. This domain is found either on its own or in association with the tRNA synthetase class II core domain (pfam00587). It is involved in the tRNA editing of mis-charged tRNAs including Cys-tRNA(Pro), Cys-tRNA(Cys), Ala-tRNA(Pro). The structure of this domain shows a novel fold.	1.18008e-27

>NZ_CP042862.1|WP_010146187.1|3090560_3091343_-|ABC-transporter-ATP-binding-protein
MTTTTPQRGSAPTTTRQGSALAASALDLTKTYGRGEAAVTALDGVSVGIEARRFTAIMGPSGSGKSTLMHLLAGLDTPTSGRVHLAEHELSSLSDGQLTRLRRESVGFVFQAFNLLPTLTARQNLRLPLDLAGRDVDAAWERTVVDALGLTERLDHRPGELSGGQQQRVALARALVTRPAVIFADEPTGALDSTTGAEVLALLRRSVDEWGQTVVMVTHDPGAAAVADRVLMLADGQIAGELDHPDADAVLVALRDLGRA
>NZ_CP042862.1|WP_051125073.1|3088056_3090561_-|FtsX-like-permease-family-protein
MARGWMTAGLASRGRRLVAAAVAIIIGVGFLTASAVILATAQKELEDAVAAGLREADLVLTGESGPVDLEAYDEVAAIEGVSGVTGEASVFTERAGDYFPGTSLPLAGATLLSGELPTGSGEIAVNPAAADDGLALGDTVSITGAPTEGGGRGEAVDVTVVGIVEPGPVHPLTFGLGYVASDPTLRELDPALTYQHVVIELADGADPVAVRDAITGTVPDATLSTGPEAAERAVTAATGGTAVLGAILLGFGGVALLTASLVIANTFTITLAQRTGELALLRCVGATRAQVRRSVVLEALVLGLVTSVVGVLAGVGAGAGLLAVARQLDLGIPMGDGLALGWPSLVLPVVVGVAVTVLASLWPAARATRVSPLAALRPSDLPSEGSRAGLVRIALAVLLLAGGTGLMVMAAISREVLLGVLGGVVSFGGVLLASILVVPWAVRALGLGARVAGVPGRLAVAGAVRNPGRAAATSAALLVGVTLITMTSVGAASGQRTALGEIDKEYAVDLVAEGAPADPGPASGGSEEFLVPSPVDDDLAARLGDVDGVDAAVAVDTAYLRMGESMDPTRAVALDRGAAEQVLRSEDLVDRVEPGIAGLGDTDLAIHGLSAGDELRVSGAEGSRELRVVELGVGGSRLALHPDDLAALAGDSARQGAVLLRLGEQADVVATMTGVSEITDEAGLQLDGAAGLRAQIVQILDVMVLVATALLGVAVVIAVVGIANTLSLSVIERHREHALLRGLGLTRGQMRVMLMVEGVLLALVSAGIGLALGVAYAALGIQTLLPEGTPLALAVPWGRVGIIVAVALLAGALASVLPARRAARVSPAEGLAAA
>NZ_CP042862.1|WP_010146181.1|3081605_3085037_+|UvrD-helicase-domain-containing-protein
MTIPHFSITDPLPSGTVLLEASAGTGKTWTIAALVTRYVAEGVVLLPEMLVVTFGRAASQELRARVREQLVAAERALSDPPPLEQRDDLVTLLLDVDDQERETRRRRLRTALSDIDAATIATTHQFCQQVLRSLGVAGTADAGAELVDDLDRLLVEVVDDLYLRAFALRDDEPFFTRREALQIARTVVDDIHADLRPTAAEPGSVPGRRVRFAQAVRAELDLRKQRLQVMHYNDLLTQLADALERDDSPARARMRGRWKVVLVDEFQDTDPIQWSVLDRAFTGQAHAMVLIGDPKQAIYAFRGGDVPTYLTAAATADDRRTLPRNFRSDPGLTQALGSMLTGAQLGDEQIVVHPVTAHRTDSRLTGAPSSAPVRVRQVLLRDHLGGDTRMPTVRPWIARDLAHDVAALLASGATFDDRPIQARDVAVLAHRAKDLLEAQSALRELGIPAVSTGGSSVLASRAAHEWLALLEAMVAPHRPMLTRAAALTDLLGYAVAQVGARGEREDTELEDALAQTCRELAGVYARHGVAAVLELLTARGLPARVLSQVGGERSLTDLRHVAQLLHETARHDQLGLVALLEWLRAGMAEDSPQSAGARTRRLDSDAAAVQLATIHGSKGLQYPVVYLPSLGDRWVSDSPAIPLFHDDPPERTRCLDVGGEHPANPGWPESVRRHKEEDAGESLRLLYVALTRAQSQVVTWWAPVNNASDSALHRVLFGREPGQDEVPAKVGVPRQDDVATARLQRWADEGAFVLERADQASEVPLVPSPPAPELALAAWTRRIDHEWRRTSYTALSTPAETEVSVAGVSSEPEVGVTGREDEPSGPDPVIDTVPALPGLDAVAPAPGAEVPSPMADLPVGATFGSLVHAVLEHADPQAPDLAAELRRHIGEQRVLWPVDLGEGGTDLLAEALVAVCDTPLGPLADGTTLREIGTVDRLCELDFELPLGGGDLRRARPGDDAAALLGDLVPLLRSHLPAGDPVRGWADVLDAAPDLAGQQLRGYLTGSIDVVLRVRAGSGDDEGRFLVVDYKTNWLGSPEEPLTAADYRPERLDEAMGHSSYPLQALLYAVVAHRFLRWRLPGYDPARHLGGVLYLYLRGMCGPDTPVVDGMPCGVFSWKPPVALVLGVSDLLDGADRPEGMRS
>NZ_CP042862.1|WP_010146180.1|3078078_3081609_+|exodeoxyribonuclease-V-subunit-gamma
MTLFVHRDTSTAKLADGLADLLATPLPDPFAQEVVAVPAKGVERWLAQRLSHTLGAGTSGHDGVCAGVRFLNPHSLVAMVLGIERDDPWHPDRLVWPVLEAIDGSLSETWATTLATHLGYDASGAEGELRRGRRYAVARRLAGLFAAYAGSRPAMLTDWREGGDGDGLGSPVDADLAWQPPLWRRVLARVDAEPPDVRQARVVQALRSGTHAGPGGELDLPGRLSLFGHTRIARSEVEVISALAEHRDVHLWLPQASPTAWDALAEDARSGPVPREDDMSALLIDHPLLASLGRDARELQRTLALAPHTLLRSDAAPATTTPARPAAPGPGQTSLLHLLQADLAADHPPTDAERAARAIPEAERSLQVHACHGQSRQIEVLRDVLADLLQHDPTLEPRDILVMCPDIDAYAPLVHAGFGLGEVGRERDAGGVGGSIPTHPAHSLRVRLADRAPTQANPLLGLAARLVELAGGRLTAGEVLDLARTAPVRRRFGLDDDDLERLGDWVGSVAIRWGLDDAHRGDYALPGLTQNTWQAGLARVLVGAAVDGQEVDHLGTTLGLDDLDSADLDLAGRMAELVARLGGTLRALRSATAVPEWVEALTDGVLGLADVAPADAWQVTQLRRELDLVGVHASAPATEGGDLALSLSDVRALLEEHAAGRATRSNFRTGTLTVCTMVPMRSVPHRVVALVGLDDGVFPRTTAPDGDDATARRPVTGERDPRSEDRQLLLDAVMAASDALVITYTGFDEHTGAPRPPAVPLGELLDAVRRTADPDSPGVCRVLTEHPLQPFDPRNLGASREGARALLPGGAPFSFDPAALAGGRAAVAPRTPRPLPVDASLGPLAPAEAESVALDALLRFFDNPARAYLRDRLGLVLPEVPEEQGEGIPIDLGGLETWAIGDRVLQAVLAGRDPGATVDAELWRGELPPRALGATVMGEVTKQAQLVAEATWSTVGQGGWGIPLDRDTLDIDLTLPSGVRLTGTLTGLVGHRAVKATYSTIKAKQRLQSWITSLVLAAALGPEASSHLFGRQRRGRKPGGVHFTHGPHDPDQALGLLDQLVDVRARGMVEPLPLPVQTALRWAESYLGGPGDARAATLDAVREWRTDDTFEQAFPKEQDDPSHSYVFGVSAPLQDILGVAREDERWEPGVEHRLGQLALRVWGPVLRGGAERRQSV
>NZ_CP042862.1|WP_158640888.1|3077717_3077987_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MSLNIKNDRVHALAREAARITGRSQTSVIEEALTRLLADYGADPSTVSQGRKLDLAHQILAEYAADPGLAGRAIREPDDLYDELTGLPR
>NZ_CP042862.1|WP_010146178.1|3077322_3077721_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MIIDSSAVMAVLQQEPGAEDLLRVLAASPSRISAATLVEVGIVADARSTAHGERLDHLLDVLEITVVPVSARQAQVARLAYRRFGRGSGSPARLNFGDCFSYALAVEAGEPLLFVGSDFTHTDIAAAPRSRA
>NZ_CP042862.1|WP_010146177.1|3076606_3077299_-|dienelactone-hydrolase-family-protein
MPTEDVFTLPRPDGDLPVHRFRPDDPAHAGIVLVQEIFGVSPYIRDRARDLAEAGYEVHVPELYWRIPDHEVDGSGEQMLQHGMELMGRTDWDGAVEDTVTAVEHLRGAVEGRVGLVGFCYGGGVAFAAAAQTSVDALVSYYGSALPGLLDLAPQVTAPSLHHWGTDDAFIPRETVEEIERAVARDGVEFVWHDGAGHAFDNPLPAFFHAEASAAAWPRTLTFLGRHLRG
>NZ_CP042862.1|WP_033228458.1|3075666_3076518_-|methylenetetrahydrofolate-reductase
MSNKCPSVALEGLLRGARLEILPTGSIAEQVHAHVEPGRTVTVTASPAKGLEATLALTEELADRYHVVPHLAARMVGRAELPDIVARLRAAGVTEIFVPGGDATPTETAFTNALDLLIELEELGRPFERVGITGYPESHPGIDDDVIVQSMWDKRRYATDIVSNMTFDDEQVGRWLERIRRRGIEQPVWIGVPGPVDPAKLLKMATVIGVGDSMRFLRKQHGVFTRIALPGFTTTRFAHRVAALAGTERLGIGGLHLYSFNQVEKTEAWRREQLSRAADLRRP
>NZ_CP042862.1|WP_141567571.1|3074638_3075409_+|DUF1638-domain-containing-protein
MSSSRTAATSTTASSTNSPSPRPDSSIAATDRRRGPDALPLRVEGARVALVACGALATHAAAAAARHTPALPVDVHPLPPLLHNHPARIAAEVEAVIDRLAGRYDRVIVGYADCGTYGALDELCARRGVARLPGLHCYDLYAGEARIAQLMEEEPGTYLLTDFLVRSFDRTVWAELGLDRHPELRDDYFGHYTRCVWLTQEPEPDAELTTQAEAEADLTRAAQRAAALLGLPLQLETTGLTGLDDALARLVLADDA
>NZ_CP042862.1|WP_141567570.1|3072657_3074709_+|DUF4445-domain-containing-protein
MGYVVDRRPPRAAGGRGDVRQPQAGAGTAQGAVIRAAGAAAELDDASGSVAETTPERVDLTYTPSGTTVRVPSGVNLFEAASWNGIAVDSTCGGHGTCRKCKIQVTEGERPPVLPQDERTFSPGQLEAGWRLGCLALARSSLTVDVPPLTTRPKASTVGVGRQVILRPSVQKRYVELEEPTLADQRPDLARLLDAIEDLEPTPELHALRRVGTALRAADYRVTAVVADDRLIDVEEGDTTGRSFGIAVDLGTTTVVATLMDLTTGTPVAVASMLNAQQPFGGDVISRISATMLDPQALPRLRVRAHETLAELAAEVCAEAGVEPREVYDVAIAGNATMVALLLGQDPEPLGVAPFILATHRWPLVPAGEVGLGEAVHPAAKAFLHPALGAYVGGDIVAGIQASGMDRDSRVRLMIDIGTNCEIVLSDGTQLVSTAAPAGPAFEGASIRCGMRAADGAIETVKLLAEWPEPADGDEPLPDPVQLGVIGDVEPRGLCGSGLVDAVAELSRVGLLDSSGRLLDAEAARAVAPALADRLASVGDAGERVFVLHRESPDLPAAESVYLSQRDVRELQFAKAAISTGWTLLLEEVGLEPREVQQVLLAGSFGSYLSPAAAVRIGLVPKLPTLRIVAAGNIAGEGAKMVLLSATERTGADALLEGVRYVELSDRSDFNDRFVDQLAFPST
>NZ_CP042862.1|WP_010146188.1|3091562_3092276_-|response-regulator-transcription-factor
MTDAPTRLFLVDDQELVRAGFRMVLDAQDDMTVVGEAGDGQTALEAIAQTRPDVVLMDIRMPRMDGVETTRRLLGEDGRGGAAGPKVLVLTTFDLDEYVYAALKAGASGFLLKDAGPAELLSAIRAVHAGDAAMAPSTTRRLLERFVPELPEAGSEGAAARDRRVAAARLEPLTEREREVLEAVGRGLTNTEIAAELFLAEATVKTHIGRVLAKLGLRDRVQMVITAYQTGLVGRPE
>NZ_CP042862.1|WP_158640889.1|3092272_3093646_-|sensor-histidine-kinase
MRVTTAAAREMAQQVRTWARSTPWLPDVALVAALLLLMVVGGAGLGGPAFLAISLVQIVPLVWRRTHPLPVAVVVAVGCLLQLVLLPGPLTSNIAVLIVIYSAAAFGSPRTSRIVLIMGLAGALIGALRWSAYYGFGSFLSIVAIQATFLACFVGVAWVLGDVMRRRRAVVARLTEQNRALARDQSQRERLAAQDERASIAREMHDVVAHSLAVVVVQADGGLYAARQALSKDPGIAADRAALERAATTLETLADTARASLADTRRLVGVLRDASSGAEYSPLQGLAHLDDLVDRVRSSGVDVQAHVRGDVAALPQDVDLAAYRVVQESLTNAMKHAGPDASVDVDVLRTPEVVLVRVSDDGLGRHGAASDGEGNGLVGMRERVEVVGGTLHAGPRQRRGWEVVATLPVPVGSEVPDAAGADAAGPDAVAPEAAEAPTVAAASYASSDTTRMPEGER
>NZ_CP042862.1|WP_010146190.1|3093729_3094932_-|imidazolonepropionase
MSMLITGIRELVTCDDTVEETAGSPLTEGLGVIPDAAVVIGGGGEDAAPAVEWIGPADQAPDADWAIDLGGKAVLPGFVDSHSHLIFAGDRSAEFAARMTGQAYDGGGIAVTMEATREASDATLRALIQARVAEMRAQGTTTVEIKSGYGLDVEHEVRALRLAREVTTETTFLGAHVVPPDAREAGGRAAYLDLVCGEMLAACAPSARWIDVFCEPASPHAFDGEESRRVLEAGRDAGLGLRVHGNQLSHGPGVQLAVELGAASVDHCTFLSDEDVDALAGSSTVATLLPGVEFSTRQPYPDARRLIDAGVAVALATDCNPGTCNSSSMPLMIALAVREMGMTPAEALRAATVGGARALRRDDVGRIRVGQRADLAVVDAPSVLHIPYRVGVPIVRALEI
>NZ_CP042862.1|WP_010146191.1|3095023_3096421_-|formimidoylglutamate-deiminase
MSARTTFHAPAAHLPQGLRRDVRLTVEAGRFVEVSDGIPAQLGDHRLSGVVLPGLANAHSHAFHRALRGRTHTGGGTFWTWREGMYAIAARLEPDTYLALARAVYAEMALAGVSAVGEFHYLHHAAGGKRYMDPNAMGHALVQAAADAGIRLTLLDTCYLAGGLDGAGYAALEGPQLRFGDLDAEAWALRVDDLHDHTDGGPAHVRVGAAIHSVRAVPRPDLAVVAGWARDGAVHPPGEHGAHGGTAGTSRPVHLHLSEQPAENDACLAAHGMTPTALLEAEGVLGPDLSAVHATHLTDADVALLGRHRAHACFCPTTERDLADGIGPARALRDAGARLSLGSDQHAVIDLLEEARALEMHERLATLERGRLAPADLLGAATAHDSIGWPDAGRLEVGARADLVAVRDDTVRTAGSDPAQILLAATAADVDTVVVDGRVVVEQGRHQLGDVGALLAEAIAPLWQE
>NZ_CP042862.1|WP_081480442.1|3096417_3097764_-|allantoate-amidohydrolase
MRTRVSRPASETPGVRRPSRRKRRGPRVESVSTAVAEHLRTFDRLWADLDSVGRVGSGGYRRFAWTREDATLREWFAGEATARGLDLVEDRVGNQWAWWWDGPGSVDDAARAGQKAVVIGSHLDSVPDGGAFDGPLGVVSSFAALDALRARGISPAVPVAVTNFVDEEGARFGIACAGSRILTGALEADRARGLTDADGVTYVDALAAAGRDPQHLGPDAEALARIGCFVELHVEQGRALVDLDAPVAVASDIWPHGRWRFDFPGEANHAGTTRLVDRRDAMLGYADLVLQARDVATRRGCVATVGKVAVTPGGVNAIASHVTGWLDARGADEAEVEALVADLTARAGETLGSVTRESWTPTTRFDEALSGRLRAVLGSDDALSVPVLGTGAGHDAGILATAGIPTAMLFVRNPTGVSHSPAEHAEQADCHAGVDALAACVADLVAHP
>NZ_CP042862.1|WP_010146193.1|3097762_3098245_+|hypothetical-protein
MSEERALAAVETAGLEYAVTRHGRVGSLEEAARVRGVEPRDIVKTMVVRRGEDDYLFVLVPGDREISWPRLRALLGVNRLSMPDAETAREATGFERGTITPFGSTTAWPVIADASLAAADEPDRRISLGAGAHGVAVTVGARDALAALGAQVADVTELSG
>NZ_CP042862.1|WP_010146194.1|3098234_3098777_-|Uma2-family-endonuclease
MSMTEVGVYTVEDLYAYREQRDDMTIQLIEGELVVSPSPAVIHQVVSGELFAILRAACPPELRVLAAPLDVRAGERSMLQPDLIVVPRELRSGGQVETPPLLAVEILTPSSRRTDLVAKPQVMARFGCPHYWVVDPEAPAVQALRLVGGGYVPAAVAEGDDELVVTEPFAVRFRPVDLTR
>NZ_CP042862.1|WP_010146195.1|3098885_3099308_-|PPOX-class-F420-dependent-oxidoreductase
MTSSAVQRLGSEEFLLVTTFRRSGEGVPTPVWVVPLSDGERIGFYTTMGTGKTKRLRHTARVLVQPCSRTGAPTPGTRPTQATAEMVQGGAEFEEVQAGVREKYGWQTRVLRLVGRFSNRGKGRTYGDTVVLIRPETKAA
>NZ_CP042862.1|WP_010146197.1|3099414_3100737_-|YjiH-family-protein
MSTQTRPTDVPATSAPMWKFFAFSAIGVLMFFVPVTIGGRSTIPLDHIVSWVREAIPGVLPWYALALIVAGAAYPWVTGQWRRSTTDLVFAVARVVGLVVGVMLVLGIGPAWLFADGMGPFLLNALVIPVGLLVPIGAIFLALLTGYGLMEFVGVLARPVMRPLFRTPGRSAIDAVASFVGSYSLALLITNRVYLEGKYTRREAMVIATGFSTVSATFMIVVATALDLMQHWSLYFWSTLLITFAVTAITVRIPPLGRMTDETAPGVEPAPEQPVQGSRVAAAWGEARHTVAADPGILRVIASTFVDGIKMAMAILPSILSIGLLGLVLAEYTPIFDWLGYLFYPITWALQIPEPLLVAKASALGVSEMFLPAALVAESAMSVKYVVAVVCVSQVIFFSAMVPSLVGTQIPVSLPKLLVIWFERVVLSLVLAIPVGLLLF
>NZ_CP042862.1|WP_010146198.1|3100733_3102398_-|urocanate-hydratase
MEGARPVRAARGTTLTARSWATEAPLRMLMNNLDPEVAERPDDLVVYGGTGRAARDWKSFDAMVRTLTDLREDETMLVQSGRPVGVMRTHEWAPRVLIANSNLVGDWATWPEFRRLEQLGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVAAKKFGGTLAGTLTLTGGCGGMGGAQPLAVTLNGGVCLVVDVDESRLRRRVKSRYLDEVADSLDAGIERALAAKGTREAVSIGVVGNAAEVFPELLRRGVEIDVVTDQTSAHDPLSYLPTGIDLSDWHDYAEKKPEEFTDRAQESMARHVEAMVGFMDAGAEVFDYGNSIRDEARQGGFDRAFEFPGFVPAYIRPLFCEGKGPFRWAALSGDEKDIAATDKAVLDLFPDNDHLHKWIRGAQDRVAFEGLPARICWLGLGERDKAGLRFNDMVASGEVSAPIVIGRDHLDCGSVASPYRETEAMADGSDAIADWPLLNALVNTASGASWVSIHHGGGVGIGRSLHAGQVSVADGTDLARQKLERVLTNDPGMGVIRHVDAGYDRADEVAAERDVRIPMREGEQA

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Crispr_ID: NZ_CP042862_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042862_8

3178435-3178532

Orphan

Consensus_repeat	Method
CCCACACCCACCACACACCTGCGCTGGTCATCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042862_8

>merge|NZ_CP042862|8|3178435-3178532|CRISPRCasFinder
CCCACACCCACCACACACCTGCGCTGGTCATCGGGGACCGTGGTGGCTCCGGGTCGCTCTGACGACCCACACCCACCACACACCTGCACTGGTCATCG

>NZ_CP042862|8|8|3178435-3178532|CRISPRCasFinder
CCCACACCCACCACACACCTGCGCTGGTCATCG	GGGACCGTGGTGGCTCCGGGTCGCTCTGACGA
CCCACACCCACCACACACCTGCACTGGTCATCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042862.1\|WP_010146278.1\|3174024_3175062_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP042862.1\|WP_010146598.1\|3185773_3186442_-\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224715
NZ_CP042862.1\|WP_010146272.1\|3167882_3168902_+\|ATP-dependent-6-phosphofructokinase	unknown	unknown	gnl\|CDD\|274155
NZ_CP042862.1\|WP_169316054.1\|3184559_3185729_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP042862.1\|WP_081480476.1\|3181052_3181595_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP042862.1\|WP_033228608.1\|3182208_3183237_+\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NZ_CP042862.1\|WP_141567507.1\|3178670_3180464_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP042862.1\|WP_010146592.1\|3181615_3182197_+\|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein	unknown	unknown	gnl\|CDD\|238451
NZ_CP042862.1\|WP_141567508.1\|3183681_3184551_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
NZ_CP042862.1\|WP_010146276.1\|3171935_3172985_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP042862.1\|WP_010146277.1\|3172981_3174028_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223682
NZ_CP042862.1\|WP_010146275.1\|3171003_3171843_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP042862.1\|WP_147899892.1\|3176239_3177589_-\|IS4-family-transposase	unknown	unknown	gnl\|CDD\|379017
NZ_CP042862.1\|WP_010146279.1\|3175058_3175895_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP042862.1\|WP_010146588.1\|3177830_3178280_+\|PH-domain-containing-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_147899860.1\|3169704_3170979_+\|threonine-ammonia-lyase-IlvA	unknown	unknown	gnl\|CDD\|236318
NZ_CP042862.1\|WP_010146273.1\|3168888_3169569_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NZ_CP042862.1\|WP_010146594.1\|3183329_3183569_-\|MoaD/ThiS-family-protein	unknown	unknown	gnl\|CDD\|340452
NZ_CP042862.1\|WP_010146600.1\|3187949_3188210_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042862.1\|WP_081480483.1\|3186438_3187893_-\|sodium:solute-symporter-family-protein	unknown	unknown	gnl\|CDD\|271357

Protein	Function_ID	Function_description	E-value
NZ_CP042862.1\|WP_010146278.1\|3174024_3175062_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	1.12034e-71
NZ_CP042862.1\|WP_010146598.1\|3185773_3186442_-\|FCD-domain-containing-protein	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	8.81235e-40
NZ_CP042862.1\|WP_010146272.1\|3167882_3168902_+\|ATP-dependent-6-phosphofructokinase	gnl\|CDD\|274155	TIGR02483, ATP-dependent_6-phosphofructokinase_1, phosphofructokinase. Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis].	3.57722e-146
NZ_CP042862.1\|WP_081480476.1\|3181052_3181595_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.79526e-15
NZ_CP042862.1\|WP_033228608.1\|3182208_3183237_+\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	2.945e-159
NZ_CP042862.1\|WP_141567507.1\|3178670_3180464_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	9.36531e-62
NZ_CP042862.1\|WP_010146592.1\|3181615_3182197_+\|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein	gnl\|CDD\|238451	cd00886, MogA_MoaB, MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.	3.13e-53
NZ_CP042862.1\|WP_141567508.1\|3183681_3184551_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	7.98028e-124
NZ_CP042862.1\|WP_010146276.1\|3171935_3172985_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	5.57984e-53
NZ_CP042862.1\|WP_010146277.1\|3172981_3174028_+\|iron-ABC-transporter-permease	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	1.00345e-79
NZ_CP042862.1\|WP_010146275.1\|3171003_3171843_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	1.3332e-64
NZ_CP042862.1\|WP_147899892.1\|3176239_3177589_-\|IS4-family-transposase	gnl\|CDD\|379017	pfam13006, Nterm_IS4, Insertion element 4 transposase N-terminal. This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), pfam01609, at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain.	7.09251e-25
NZ_CP042862.1\|WP_010146279.1\|3175058_3175895_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.30523e-126
NZ_CP042862.1\|WP_169316054.1\|3184559_3185729_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	3.59014e-147
NZ_CP042862.1\|WP_147899860.1\|3169704_3170979_+\|threonine-ammonia-lyase-IlvA	gnl\|CDD\|236318	PRK08639, PRK08639, threonine dehydratase; Validated.	0
NZ_CP042862.1\|WP_010146273.1\|3168888_3169569_-\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	1.46371e-37
NZ_CP042862.1\|WP_010146594.1\|3183329_3183569_-\|MoaD/ThiS-family-protein	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	5.07973e-11
NZ_CP042862.1\|WP_081480483.1\|3186438_3187893_-\|sodium:solute-symporter-family-protein	gnl\|CDD\|271357	cd10322, SLC5sbd, Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain. This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.	9.44572e-79

>NZ_CP042862.1|WP_010146588.1|3177830_3178280_+|PH-domain-containing-protein
MPSVRILPPRRTSWGQTVLWALQVVVWLIQAAQRWGDGGAWAAVSVAFLLLSVVMLILALTGRMTRMLTVRADAEGLHRSRLNGRRFTPWGEVARIRPAPARPLRRHQETTTRLEIRAHDGRTLAAGRLLTEPEVAQLHTWHHQASHPG
>NZ_CP042862.1|WP_147899892.1|3176239_3177589_-|IS4-family-transposase
MSARVLAPVDPFAAGHLGELTRIVSVDLVDAAIETAGAAQKRVRRLPTRVVVYLLLAAVLFADVGYQQVLRRLVCGAGLSVKPPGSSALSQAFRRIGVAPLRELFDLVRGPAAGSPRWHGLLVCAIDGTTMAVPDSAANAAGFGRQTARPGSPAGYPMLRLVSIIACGSRTVLDAVFGSYLVGETTYAPRLAGCLRPGMILLGDRNFAATALLEQFAATGADLLIRCKNDRRFQVLSHLGDGTRIVALGQLRVRVIDARITVDLGSGGEQRTGRYRLVTTLTDPLLHPAMEIVELYHQRWEIETSYREAKARILDGRVLRARTPAGIAQEVYAVLIVHQALRTAIADTALSTAGGVAPDRLSLTIALTAARDSIHNAASILTQSGTDLTGRIGAAVLDGLMPARRSRSSPRVTKRAISKHRAKGTVDRNNYQTTITTHLLTVLDTNHDG
>NZ_CP042862.1|WP_010146279.1|3175058_3175895_+|ABC-transporter-ATP-binding-protein
MTDSHTLRAEGVRLGYADRTVVEDLDLGIEPGRITAIVGANACGKSTVLRALSRLLRPGAGQVVLDGADIHRQPTKVVARTLGLLPQSPTAPEGIAVGDLVARGRSPHQRMLSRWSAADDLAVAQALELTGTGDLVDRAVDELSGGQRQRVWIAMALAQQTDILLLDEPTTFLDISHQVEVLDLLTDLNATRGTTVVMVLHDLNLAARYADRLVAMAGGRVVASGAPQDVLTAEVVDAVFGMPSQVIPDPVSGKPMILPIGRHHTAVGVDVRGGSGTL
>NZ_CP042862.1|WP_010146278.1|3174024_3175062_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MSATTTLEALRAGRRSRGAHRRRTVIALATVVAALFAVSLMVGQTFYGPGEVLGVLLGQDVPGASFTVGTLRLPRAVLALAAGAALGAAGVTFQTMLRNPLASPDIIGISAGASAAAVIGLVVLHLDEAVVSGLAILAALATATVIYLLAYRDGVLGTRLILIGIGISAMLDSVVSYVIVRAATWDLQTAMRWLTGSVNGASWTTVLPLVVACLVLLPVLVAQSRGLSLMQHGDDTAAALGVRVERTRFTVIAVAVTLIAFATAAAGPIAFVAFLSGPIAARIAGSGGSLVVPSALVGSLLVLAADLVGQHAFGTRYPVGAVTGALGAPYLVYLLIRTNRSGGSL
>NZ_CP042862.1|WP_010146277.1|3172981_3174028_+|iron-ABC-transporter-permease
MTLTLAPVTPPPTAPRRSAAVSRAGLLLLALVALVAAGLLSVTFGARDIALGDLVAALTGSEANVSQAAVRQRIPRTILAMLVGAALGLAGAVMQGVTRNPLADPGILGVTTGASLAVVSGIAFFGLASPTGFIWVAIIGAGLAASFVYAVGSLGRGGATPLKLALAGAAISSAFSSLISAVLLPRIDVMDSFRFWQIGGVGGASIDKIVTVAPFLLVGALLCVGTARGLNSLALGDDLAAGLGEHVGLTRATAAIGAVMLCAAATAVAGPIGFVGLVVPHTCRLLVGSDHRWLLPASVVTGAILLTLADVIGRVVARPSEVDVGIVTALVGAPVFILIVRRMRARAL
>NZ_CP042862.1|WP_010146276.1|3171935_3172985_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MSTSRTTSVGLALTTALVLAACGGGASTGEGEDTEAGSAAPEADAGAFPVTVSHAFGETTIEEQPERVATVAWSNHEVPLALGVVPVGMSEAAWGDDDGDGVLPWVEDRLTELDAETPVLFDEADGIDFEAVADTEPDVILAAYSGLTQEEYDTLSQIAPVVAYPETAWNTSMADMISLNSQALGLAEEGEQLNAELEQQIADAAAEHPELEGTNAMFAYLDPNDLSQVGFYTTADPRAMFLEQLGTGVPTTVEEISGSSEAFYETVSAEESDSFDDVELIVTYGTEETLEAIQDDPLLSAIPAVENGAVVVLEDNTPLAASTNPSPLSIEWGLSDYLGLLDDAVAQAQ
>NZ_CP042862.1|WP_010146275.1|3171003_3171843_-|siderophore-interacting-protein
MGRRTAQVARRKPVDARPLRVQVLHRSRPLPSLARVTLGGGEIADLTPMGFDQWFRLFLPTGGIDSLRHVPQALTTASYARFMLVPADERPIIRNYTIRAYRETGIHGEGPEIDVDLVVHGSPEEGTCGPASTWAQTCAVGDEVAIIDEGAIYAGPEEAQVLLAADESGLPALAGILRDLPCAAQGVAVVEVPHPDDRHDLGGPDGVEVRWVVRGAPGGRPGTAALAELATVPVPEGEVYAWVAGESDLATSARRHWVRHGIPKAQISFCGYWKSGTSH
>NZ_CP042862.1|WP_147899860.1|3169704_3170979_+|threonine-ammonia-lyase-IlvA
MSSLPSVSAGSALPSAADIEDAAERIAGRVSRTPLTRSVRLSEETGATVWLKREDQQPVRSYKGRGAANLIAQLDSEQIWAGVVCASAGNHAQGVAHACATLGVNARIYLPANTPRQKRDRVASIGGDWVEVVVGGRTYDEAAAAALADVERTGATLVPAFDHPHTIAGQGTIAREISEDLPDPPDVVVVPCGGGGLLAGCLTWFGEHAPGVKVVAAEPAGAASMMAATHAGEPVALPEIDRFVDGAAVQKVGTHTFEVVRRHTPALVAVPEGRICTEMIRLYQSDGIIAEPAGALAAAALESLGDLSGQTVVVVVSGGNNDLLRYPEVMERSLIHEGLKHYFLVDFPQEPGMLRQFLNEVLGPDDDIALFEYVKRNNRETGPALVGIELGAREDLAPLLERMDASSMQIEPIQPDSPLFRFIL
>NZ_CP042862.1|WP_010146273.1|3168888_3169569_-|HAD-family-hydrolase
MRAVLFDLDDTLIDQRSAMRAAVVPWAAEQGVTGAGVMDRWDAIAERHYARYQRRECTFQEQRRARVHDFLGLDLSDEAADAVFGRYLERYEAGWALLPGAVAALTRVRAAGLRVGILTNGDEDQQRRKLDAFGLSRRVDVLVASSALPAGKPDPRAFAAAVSRLRVAAQEVLMVGDSLEKDVRGALAAGLQALLFDPDGRHTDTDVPRITSLDQLLPSLRAVSRT
>NZ_CP042862.1|WP_010146272.1|3167882_3168902_+|ATP-dependent-6-phosphofructokinase
MKIGLLTSGGDCPGLNAVIRGVVLKGDRIYEHEFVGIKDGFRGLVEDDIITLPRKRVRGLSKVGGTILGTSRISPIRTGGIGRVKEVMDKHEIDALVTIGGEGTLTVARMFHDEGINVVGVPKTIDNDLSATDRTFGFDTAVSIATESIDRLRTTGEAHSRCMVVEVMGRHVGWIALHAGIASGAHAILVPEVPVTPEQLCEWVQNAMDRGRAPTIVVAEGFTFAGDEQVASDRVDGFGRPLLGGIGERVTRMVEERTGIETRNTTLGHLQRGGVPSSYDRVLATRFGTAAIDSVSAKKWGTMVALQGMDIVNVNLRDATSEIKTVPRDQWDEAAIMFG
>NZ_CP042862.1|WP_141567507.1|3178670_3180464_-|MMPL-family-transporter
MPAEDGTAAISVLALDAPTATDSQEVVTQLRTDLADGAPEGITAQVTGPAAIEADLASVFDGANITLLGATATVVALLLIVTYRSPVLWVIPLLVVGVADQVAATAATYALKAVSIPWDESTIGILSVLVFGAGTNYALLLISRYRDELRRHTSRHEAMAVALRRAAEAIIASASTVVVGVLCLLLSAFPSTRGLGLACAVGVLVAMAFVLVVLPGALVLFGRWIFWPQVPREGQPVLAESRSLWRRIGDRVAKAPAAYIAGTLVLLAAMAFGLTQIRSGLAPEDQFLQTPEAITAAERLGESFPAGTSDPLVVVTRGDEAQLEELVGVVGDIEGVTQATPVEPVDGIGQVQVVLDADPGSEEAEAAVVELRGAVGGYAETYVTGGDASALDEGEGNLRDRFVVLPLILVLVLLALMALLRSVLAPVILIASVVTTFCAALGVSWWLFTGVFGFAAIDAGMPLLAFLFLVALGVDYNIFLITRTLEEAGEHGTRDGVLRALGATGGVITSAGILLAAVFAVLGVLPLVVLAQLGVVICIGVLLDTLVVRTVLVPAIVRVLGERFWWPRRVDHAGRHRPEGEPTKDADEPSGQVAAPA
>NZ_CP042862.1|WP_081480476.1|3181052_3181595_+|MarR-family-transcriptional-regulator
MTESSTGRPAETTRAEAAPPEESRAEPIAVPGPQTQWVQAWEPGPVLDTLRRFIDTSRRATPALARRAGLTHTELTVLEHVMDEPVGPSELAQRLGVTSAAASGIVDRLVARGHARREPHPTDRRRTAVTATDSGREELLGHLMPMFVGLAQVDATLSDAEREIVLRFLTEAERAVGRLL
>NZ_CP042862.1|WP_010146592.1|3181615_3182197_+|MogA/MoaB-family-molybdenum-cofactor-biosynthesis-protein
MSQQAGEQTQHDHPQHDDTHHQDTPGRSAAVAVTISDRSSDGRREDESGRLLVEALRDLGYAVESSVVVPDGVESVAGALRAAVADGARLVVTTGGTGMGPRDLTPEGTREVITRENHGMAELIRREGARHTPFAAVSRGVVGVVDWPAERGVGGTLVINLPGRPAAVTEGMEIVGPLLRHVLSQVSGGDHSW
>NZ_CP042862.1|WP_033228608.1|3182208_3183237_+|GTP-3',8-cyclase-MoaA
MVDSYGRVHRDLRISVTDRCSLRCTYCMPEDGVPWLPRATMLTTEEVVRIADVAVSMGIEEVRLTGGEPLLRRDLVDVVAGITALEGPAGSPEVSMTTNAIGLAKNAAALHEAGMTRVNVSLDTLRRDVFISLAKRDRLADTLAGVHAAAEAGMVPVKINTVLMRGVNDAPEDVVALLTFALEHGYELRFIEQMPLDAQHGWDRTQMITGEEILGMLRTGYDLAAQPDEARGSAPAELFDVRPLGVGPDAGSPPLGTVGAIASVTMPFCGSCDRVRLTADGMIRNCLFATGETDLRTPMREGASDDELADLLRASIGAKLPGHGINQPDFLQPPRPMSAIGG
>NZ_CP042862.1|WP_010146594.1|3183329_3183569_-|MoaD/ThiS-family-protein
MATVRFFAAAAEAAGTQSEHVEADDLGSLLASLRERHGAELTRVLALSSVLHDGQYVSDPDLPLGHDAVLDVLPPFAGG
>NZ_CP042862.1|WP_141567508.1|3183681_3184551_-|hydroxymethylglutaryl-CoA-lyase
MQIVEVGPRDGLQNEPEHVSPHVRAELVRRLAGTGLRRIELGSFVDGRRVPQMAEVETVVAEAAVGQGVTLSALVLNPRGYERLREAPVPEVHLAFCSTETFNQRNQGRSVGQSVEEANALIASAHADGRRVSVTLAASFGCPFEGEVDPGVPVALAHRLEAPDEIIFADTIGVGSPRQVTALLRGAEGLGIPLGLHLHNTRNTGYANAYQALEHGVSVLDASVAGLGGCPFAPGATGNIATEDLLYLLEREGVDTGVDLDAVLEVAAWVTRLLRRDLPGQLGRAGRFP
>NZ_CP042862.1|WP_169316054.1|3184559_3185729_-|CoA-transferase
MGTLIAGPFCGQILGDFGAEVIKIEDPGAGDPMRRWGSEEIPDHDEPVSLWWPVIARNKQSVTLNLRTERGQGLARDLIGTADVLVENFRPGTLERWGLGDEVLRAVNPGLVTARVTGYGQTGPYAPRAGFGSVGEAMGGLRHVTGDPDGPPSRVGVSIGDSLAGLFSALGVSMALVARQRTGRGQVVDTAIYEAVLAMMESLVPQYAKAGVTRERTGSTLPGVAPSNVYPTAGGGTVVIGANRDTVFARLAQVMGRPNLVEDERYRDHDARGQHQEELDELISAWTSTRGAEELLEDLHAGGIPAGLVYTAADMLSDEHFAAREAITTVMHRTLGELPMQNVTPKLSSTPGGIRHLGPELGEHTDAVLSSVLGLDDAQLRELHAEGVV
>NZ_CP042862.1|WP_010146598.1|3185773_3186442_-|FCD-domain-containing-protein
MSEAPYAALRELLLAGTWQPHTPLREELLASQLGTSRTPVRDALRRLEADGLVEIAPRRGARVVGFSNEQVDSIFELRALLEGYAARLAAERGDVDVPALRRLAQEMERCASSGERGQIGALNLEFHHALHEAGGNVLLPRVLQSVISVSLVHTAFMVYADAELARSQGHHRELIEAVEAGDGAWAEGVMVAHIRAAHEAVRQHRVATQRDSAADPTTKGMT
>NZ_CP042862.1|WP_081480483.1|3186438_3187893_-|sodium:solute-symporter-family-protein
MLLLGFVAGRDAPEANKSLNGYFLAGRDLGLVALFFTLYATQYSGNTIIGYAPTAYRSGLSWWMSVPFMTAVVVAYLLFAPRLYMIARRHEFITPIDWIHYRFRSKALAAVVTFLLLWGLGNYLLEQLVAMGQAIAGLTGNTVPYQVGVVGFLVVMLTYSWVGGMRAVALTDVMQGIALLVGVLALMLGAVYLAGGSLGAVTDELIRSEPAKMGVPDAAGVTGWLGMIVMVGLAAAMYPHAIQRVYAASSERTLRRSLAGMAWMPLVTTGFVFFIGIIALALYPDLDEAASEQIVGRLANDVAALNPLMYVLMIILFGGVVAAIVSTADSALLAFGSMVSRDVYAPTLGKDASEARQVKVGKVVSVVAVGLLLILAWNPPGTLYQIFLLKLELLAQIAPAFILGLYWRRMSAVAVLAGVVAGAGLSGYLTIIGHDSPTGLPNGLLGLGLNLLLCIVLSIAMPDRATPELRPLRQPATSGAREVR
>NZ_CP042862.1|WP_010146600.1|3187949_3188210_-|hypothetical-protein
MQRRISTSSTSPREPIRRPLVWVLIGLTILAGVPWYLPSGLIEPVVAHLPGWFWLSIIAAVALSAVTCWACLTQWELEPHDGEDLS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP042862_8	8.1\|3178468\|32\|NZ_CP042862\|CRISPRCasFinder	3178468-3178499	32	NZ_CP042862.1	3176045-3176076	1	0.969
NZ_CP042862_8	8.1\|3178468\|32\|NZ_CP042862\|CRISPRCasFinder	3178468-3178499	32	NZ_CP042862.1	739343-739374	2	0.938

1. spacer 8.1|3178468|32|NZ_CP042862|CRISPRCasFinder matches to position: 3176045-3176076, mismatch: 1, identity: 0.969

gggaccgtggtggctccgggtcgctctgacga	CRISPR spacer
gggaccgtggtggctccgggtcgccctgacga	Protospacer
************************.*******

2. spacer 8.1|3178468|32|NZ_CP042862|CRISPRCasFinder matches to position: 739343-739374, mismatch: 2, identity: 0.938

gggaccgtggtggctccgggtcgctctgacga	CRISPR spacer
ggcaccgtggtggctccgggtcgccctgacga	Protospacer
** *********************.*******

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP042862_5	5.1\|1935907\|28\|NZ_CP042862\|CRISPRCasFinder	1935907-1935934	28	NC_010391	Salmonella phage Fels-1, complete genome	29292-29319	5	0.821
NZ_CP042862_3	3.1\|840340\|28\|NZ_CP042862\|CRISPRCasFinder	840340-840367	28	NC_010494	Arthrobacter sp. AK-1 plasmid pSI-1, complete sequence	34419-34446	6	0.786
NZ_CP042862_5	5.1\|1935907\|28\|NZ_CP042862\|CRISPRCasFinder	1935907-1935934	28	MH426726	Erwinia phage Pavtok, complete genome	58782-58809	6	0.786
NZ_CP042862_3	3.1\|840340\|28\|NZ_CP042862\|CRISPRCasFinder	840340-840367	28	NZ_CP007453	Peptoclostridium acidaminophilum DSM 3953 strain al-2 plasmid EAL2_808p, complete sequence	224736-224763	7	0.75
NZ_CP042862_7	7.1\|3091466\|31\|NZ_CP042862\|CRISPRCasFinder	3091466-3091496	31	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	179147-179177	8	0.742

1. spacer 5.1|1935907|28|NZ_CP042862|CRISPRCasFinder matches to NC_010391 (Salmonella phage Fels-1, complete genome) position: , mismatch: 5, identity: 0.821

gggagctgcgtcacccggcaggcctcac	CRISPR spacer
atgagcagcgtcgcccggcaggcctcaa	Protospacer
. **** *****.**************

2. spacer 3.1|840340|28|NZ_CP042862|CRISPRCasFinder matches to NC_010494 (Arthrobacter sp. AK-1 plasmid pSI-1, complete sequence) position: , mismatch: 6, identity: 0.786

cgcgccc---atcctcaccgggggaggccct	CRISPR spacer
---gttcaagatcctcaccggcggaggccct	Protospacer
   *..*   *********** *********

3. spacer 5.1|1935907|28|NZ_CP042862|CRISPRCasFinder matches to MH426726 (Erwinia phage Pavtok, complete genome) position: , mismatch: 6, identity: 0.786

gggagctgcgtcacccggcaggcctcac	CRISPR spacer
gggagctgcgtcagccggccggcaacgg	Protospacer
************* ***** ***  *.

4. spacer 3.1|840340|28|NZ_CP042862|CRISPRCasFinder matches to NZ_CP007453 (Peptoclostridium acidaminophilum DSM 3953 strain al-2 plasmid EAL2_808p, complete sequence) position: , mismatch: 7, identity: 0.75

cgcgcccatcctcaccgggggaggccct----	CRISPR spacer
ggcgcccatccacaccggggga----ttgaaa	Protospacer
 ********** **********    .*

5. spacer 7.1|3091466|31|NZ_CP042862|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.742

gacccacgggacgctccacccgtggcgggca	CRISPR spacer
gttccactggacgctccacccgtgggcgatc	Protospacer
* .**** *****************  *..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1310397 : 1363032

Gordonia_phage(25.0%)

integrase,holin,transposase

attL 1302973:1302990|attR 1375705:1375722

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1302973:1302990	attL	NA	NA	NA	NA
WP_147899702.1\|1310397_1311693_-\|integrase	tyrosine-type recombinase/integrase	A0A1P8DJP1	Virus_Rctr41k	4.4e-06	27.0
WP_147899770.1\|1311689_1312796_-\|integrase	tyrosine-type recombinase/integrase	A0A166YH27	Gordonia_phage	6.2e-09	31.5
WP_141567781.1\|1312861_1313431_+	hypothetical protein	NA	NA	NA	NA
WP_147899771.1\|1313604_1314276_-\|transposase	transposase	NA	NA	NA	NA
WP_147899721.1\|1314268_1315645_+\|transposase	IS256 family transposase	A0A218MNI5	uncultured_virus	1.4e-31	41.1
WP_029542014.1\|1315844_1316936_-	hypothetical protein	NA	NA	NA	NA
WP_010149437.1\|1317285_1317849_-	hypothetical protein	NA	NA	NA	NA
WP_010149438.1\|1317915_1319124_-\|transposase	IS110 family transposase	NA	NA	NA	NA
WP_084452504.1\|1319490_1319823_+	bleomycin resistance family protein	NA	NA	NA	NA
WP_010147217.1\|1320125_1320959_-	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_147899772.1\|1320961_1321870_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_147899890.1\|1321869_1323153_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_033228788.1\|1323645_1324200_+	murein L,D-transpeptidase	NA	NA	NA	NA
WP_010147211.1\|1324215_1324911_+	TIGR02206 family membrane protein	NA	NA	NA	NA
WP_010147209.1\|1326051_1327587_-	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-14	30.7
WP_081480533.1\|1327616_1328711_+	substrate-binding domain-containing protein	NA	NA	NA	NA
WP_010147206.1\|1328707_1330942_+	acyltransferase	A0A166XZF2	Gordonia_phage	6.1e-72	30.9
WP_010147205.1\|1330975_1332154_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_029540657.1\|1332205_1334605_+	xanthine dehydrogenase family protein molybdopterin-binding subunit	A0A0P0I429	Acinetobacter_phage	6.6e-40	25.3
WP_010147202.1\|1334826_1335492_-	hypothetical protein	NA	NA	NA	NA
WP_147899773.1\|1335488_1336004_-	hypothetical protein	NA	NA	NA	NA
WP_010147047.1\|1336224_1337169_-	aldo/keto reductase	NA	NA	NA	NA
WP_010147046.1\|1337326_1338193_+	DUF2236 domain-containing protein	NA	NA	NA	NA
WP_010147045.1\|1338189_1338732_+	2'-5' RNA ligase family protein	NA	NA	NA	NA
WP_010147044.1\|1338728_1340216_+	cryptochrome/photolyase family protein	E3T4R9	Cafeteria_roenbergensis_virus	1.4e-77	31.7
WP_010147043.1\|1340362_1340848_-	PPOX class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_010147042.1\|1341045_1341849_-	HNH endonuclease	NA	NA	NA	NA
WP_147899774.1\|1342268_1343465_-	hypothetical protein	NA	NA	NA	NA
WP_010147039.1\|1343771_1344932_-	M20 family metallopeptidase	NA	NA	NA	NA
WP_010147038.1\|1344943_1346191_+	amidohydrolase	NA	NA	NA	NA
WP_010147037.1\|1346237_1346561_+	hypothetical protein	NA	NA	NA	NA
WP_141567545.1\|1347342_1348104_-	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_147899775.1\|1348364_1349183_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
WP_010147032.1\|1349281_1349914_+	glycoside hydrolase family 2	NA	NA	NA	NA
WP_029540570.1\|1349946_1350639_+	nucleoside/nucleotide kinase family protein	NA	NA	NA	NA
WP_010147030.1\|1350635_1351910_+	AGE family epimerase/isomerase	NA	NA	NA	NA
WP_010147029.1\|1351941_1353207_+	saccharopine dehydrogenase NADP-binding domain-containing protein	NA	NA	NA	NA
WP_029540567.1\|1353278_1353584_+	hypothetical protein	NA	NA	NA	NA
WP_010147027.1\|1353826_1355218_-	AI-2E family transporter	NA	NA	NA	NA
WP_081480510.1\|1357678_1360591_-	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_081480505.1\|1360587_1360953_-	SDR family oxidoreductase	NA	NA	NA	NA
WP_147899776.1\|1360986_1363032_-\|holin	choline BCCT transporter BetT	A0A2I7QNT1	Vibrio_phage	3.1e-14	27.4
1375705:1375722	attR	NA	NA	NA	NA

DBSCAN-SWA_2

2650417 : 2659536

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_147899831.1\|2650417_2651737_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	8.2e-77	39.4
WP_010146322.1\|2651733_2652348_-	riboflavin synthase	A0A2I2L4R9	Orpheovirus	1.7e-16	36.8
WP_010146320.1\|2654150_2655839_+	DEAD/DEAH box helicase	B2CRJ8	Acidianus_filamentous_virus	1.5e-14	21.5
WP_010146318.1\|2655950_2656658_+	response regulator transcription factor	W8CYM9	Bacillus_phage	4.3e-32	35.7
WP_010146317.1\|2656674_2658165_+	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	7.5e-18	24.8
WP_010146316.1\|2658210_2659536_+	trypsin-like peptidase domain-containing protein	W5SAB9	Pithovirus	6.7e-10	33.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP042862

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection