CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP042995	Acinetobacter nosocomialis strain J1A plasmid unnamed1, complete sequence	0 crisprs	NA	0	1
NZ_CP042994	Acinetobacter nosocomialis strain J1A chromosome, complete genome	3 crisprs	cas3,DEDDh,WYL,csa3	2	5
NZ_CP042996	Acinetobacter nosocomialis strain J1A plasmid unnamed2, complete sequence	0 crisprs	NA	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

304 : 48347

Acinetobacter_phage(28.57%)

terminase,transposase,protease,integrase

attL 7936:7995|attR 50944:52425

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_099143725.1\|304_1055_+\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.6e-24	45.8
WP_000378524.1\|1232_1700_+	hypothetical protein	A0A0P0IRI6	Acinetobacter_phage	5.3e-55	70.3
WP_106479801.1\|1837_2248_+\|terminase	terminase	A0A0N7IRE3	Acinetobacter_phage	5.9e-74	98.5
WP_000568530.1\|2416_2848_+	hypothetical protein	A0A0P0IDW1	Acinetobacter_phage	2.1e-66	90.6
WP_004882762.1\|2868_3093_+	hypothetical protein	A0A0P0IYG9	Acinetobacter_phage	2.9e-06	46.6
WP_000236586.1\|3043_3298_+	hypothetical protein	NA	NA	NA	NA
WP_001258992.1\|3376_3664_-	helix-turn-helix transcriptional regulator	A0A088CD40	Shigella_phage	7.4e-15	48.4
WP_000033474.1\|3650_3839_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A088CBP5	Shigella_phage	4.1e-14	69.6
WP_000088946.1\|4115_4436_-	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_002072923.1\|4623_5013_+	AAA family ATPase	NA	NA	NA	NA
WP_000286812.1\|6244_6472_+	hypothetical protein	NA	NA	NA	NA
WP_000069471.1\|6579_6789_-	hypothetical protein	NA	NA	NA	NA
WP_001140619.1\|6781_7084_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000269901.1\|7076_7433_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
7936:7995	attL	NA	NA	NA	NA
WP_001089571.1\|9473_9986_-	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_000447197.1\|10664_11183_+	sel1 repeat family protein	NA	NA	NA	NA
WP_016805832.1\|11340_12666_+\|transposase	ISNCY family transposase	NA	NA	NA	NA
WP_131202340.1\|13260_13485_-	hypothetical protein	NA	NA	NA	NA
WP_032012193.1\|14083_14368_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_000649019.1\|14388_15387_-	zinc-binding alcohol dehydrogenase family protein	NA	NA	NA	NA
WP_004812130.1\|15460_16201_-	SDR family oxidoreductase	A0A0N9R355	Chrysochromulina_ericina_virus	1.1e-06	26.5
WP_032012195.1\|16336_17236_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004882755.1\|17250_18267_-	zinc-dependent alcohol dehydrogenase family protein	NA	NA	NA	NA
WP_001038514.1\|18256_19252_-	zinc-dependent alcohol dehydrogenase family protein	NA	NA	NA	NA
WP_000925801.1\|20515_21430_-	aromatic amino acid DMT transporter YddG	NA	NA	NA	NA
WP_000794338.1\|21442_22735_-	MFS transporter	Q6JIH2	Burkholderia_virus	1.1e-57	33.6
WP_001094922.1\|22792_24031_-	M24 family metallopeptidase	NA	NA	NA	NA
WP_000941153.1\|24147_25107_-	GlxA family transcriptional regulator	NA	NA	NA	NA
WP_001133624.1\|25935_26211_+	metal/formaldehyde-sensitive transcriptional repressor	NA	NA	NA	NA
WP_000842149.1\|26232_27345_+	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	E3SJ82	Synechococcus_phage	1.2e-31	29.3
WP_000402512.1\|27573_28404_+	S-formylglutathione hydrolase	NA	NA	NA	NA
WP_000920558.1\|28738_29041_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_000931665.1\|29639_30797_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_000697978.1\|30887_31565_+	type 1 glutamine amidotransferase domain-containing protein	NA	NA	NA	NA
WP_106479821.1\|31768_32896_+	alkene reductase	NA	NA	NA	NA
WP_001087973.1\|32980_33211_-	hypothetical protein	NA	NA	NA	NA
WP_000804054.1\|33322_33931_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_001261184.1\|34074_35094_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
WP_000631287.1\|35110_35749_+	glutathione S-transferase	NA	NA	NA	NA
WP_000684951.1\|36160_36592_-	hypothetical protein	NA	NA	NA	NA
WP_000059657.1\|36891_38091_+\|integrase	tyrosine-type recombinase/integrase	B7SYF8	Stenotrophomonas_phage	2.5e-40	29.1
WP_004882744.1\|38299_38551_-	hypothetical protein	NA	NA	NA	NA
WP_031945173.1\|38748_38970_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_002122556.1\|39773_40520_-\|transposase	IS5-like element ISAba31 family transposase	A0A0N9SJT9	Paenibacillus_phage	2.5e-14	38.2
WP_004882738.1\|41946_44796_+	heat shock survival AAA family ATPase ClpK	K4FB40	Cronobacter_phage	1.2e-128	41.1
WP_099143681.1\|45343_45652_+	hypothetical protein	NA	NA	NA	NA
WP_148356766.1\|45800_46733_-\|transposase	IS5 family transposase	A0A1V0E8E1	Vibrio_phage	3.4e-61	42.8
WP_106629086.1\|46772_47027_+	diguanylate cyclase	NA	NA	NA	NA
WP_004882734.1\|47038_47527_+	phosphate-starvation-inducible PsiE family protein	NA	NA	NA	NA
WP_004882732.1\|47513_48347_+\|protease	M48 family metalloprotease	NA	NA	NA	NA
50944:52425	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP042994

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP042994_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042994_1

449102-449226

Unclear

Consensus_repeat	Method
GGTGGTGAAGATCGTCCGCGTCGTGAGTTCAACTCTGA	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP042994_1

>merge|NZ_CP042994|1|449102-449226|CRISPRCasFinder
GGTGGTGAAGATCGTCCGCGTCGTGAGTTCAACTCTGACCGTCCACGTCGTGAAGGTGGTTTTGAAGATCGTCCAAAACGTAGCTTTGGTGGTGAAGATCGTCCACGTCGTGAGTTCAACTCTGA

>NZ_CP042994|1|1|449102-449226|CRISPRCasFinder
GGTGGTGAAGATCGTCCGCGTCGTGAGTTCAACTCTGA	CCGTCCACGTCGTGAAGGTGGTTTTGAAGATCGTCCAAAACGTAGCTTT
GGTGGTGAAGATCGTCCACGTCGTGAGTTCAACTCTGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042994.1\|WP_016803860.1\|436245_436893_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_039246232.1\|434569_435670_+\|HPP-family-protein	unknown	unknown	gnl\|CDD\|225979
NZ_CP042994.1\|WP_006582595.1\|454991_455393_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240046
NZ_CP042994.1\|WP_032011495.1\|444385_446290_+\|1-deoxy-D-xylulose-5-phosphate-synthase	unknown	unknown	gnl\|CDD\|235470
NZ_CP042994.1\|WP_148356637.1\|439045_441388_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_002052345.1\|435739_435994_-\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP042994.1\|WP_001091949.1\|450723_451500_+\|lipid-asymmetry-maintenance-ABC-transporter-permease-subunit-MlaE	unknown	unknown	gnl\|CDD\|223838
NZ_CP042994.1\|WP_001121170.1\|443479_444082_-\|GTP-cyclohydrolase-II	unknown	unknown	gnl\|CDD\|234745
NZ_CP042994.1\|WP_148356639.1\|456023_458069_-\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NZ_CP042994.1\|WP_002049738.1\|451499_452183_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	unknown	unknown	gnl\|CDD\|275223
NZ_CP042994.1\|WP_002049699.1\|453224_454238_-\|magnesium-transporter	unknown	unknown	gnl\|CDD\|213369
NZ_CP042994.1\|WP_031982353.1\|441435_442224_-\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|234703
NZ_CP042994.1\|WP_002052337.1\|446411_447242_+\|inositol-monophosphatase	unknown	unknown	gnl\|CDD\|238817
NZ_CP042994.1\|WP_004711782.1\|449908_450727_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213228
NZ_CP042994.1\|WP_077163789.1\|452257_452851_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|377516
NZ_CP042994.1\|WP_002049746.1\|454395_454977_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|129813
NZ_CP042994.1\|WP_004884612.1\|436964_438788_-\|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|185635
NZ_CP042994.1\|WP_148356638.1\|455395_456031_-\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
NZ_CP042994.1\|WP_000250997.1\|452862_453150_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP042994.1\|WP_031982352.1\|442401_443352_-\|oxygen-dependent-coproporphyrinogen-oxidase	unknown	unknown	gnl\|CDD\|235413

Protein	Function_ID	Function_description	E-value
NZ_CP042994.1\|WP_039246232.1\|434569_435670_+\|HPP-family-protein	gnl\|CDD\|225979	COG3448, COG3448, CBS-domain-containing membrane protein [Signal transduction mechanisms].	1.33301e-98
NZ_CP042994.1\|WP_006582595.1\|454991_455393_+\|NUDIX-domain-containing-protein	gnl\|CDD\|240046	cd04690, Nudix_Hydrolase_31, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.82583e-39
NZ_CP042994.1\|WP_032011495.1\|444385_446290_+\|1-deoxy-D-xylulose-5-phosphate-synthase	gnl\|CDD\|235470	PRK05444, PRK05444, 1-deoxy-D-xylulose-5-phosphate synthase; Provisional.	0
NZ_CP042994.1\|WP_002052345.1\|435739_435994_-\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	6.1384e-21
NZ_CP042994.1\|WP_001091949.1\|450723_451500_+\|lipid-asymmetry-maintenance-ABC-transporter-permease-subunit-MlaE	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	6.58224e-82
NZ_CP042994.1\|WP_001121170.1\|443479_444082_-\|GTP-cyclohydrolase-II	gnl\|CDD\|234745	PRK00393, ribA, GTP cyclohydrolase II RibA.	1.62622e-123
NZ_CP042994.1\|WP_148356639.1\|456023_458069_-\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_CP042994.1\|WP_002049738.1\|451499_452183_+\|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD	gnl\|CDD\|275223	TIGR04430, OM_asym_MlaD, outer membrane lipid asymmetry maintenance protein MlaD. Members of this protein family are the MlaD (maintenance of Lipid Asymmetry D) protein of an ABC transport system that seems to remove phospholipid from the outer leaflet of the Gram-negative bacterial outer membrane (OM), leaving only lipopolysaccharide in the outer leaflet. The Mla locus has long been associated with toluene tolerance, consistent with the proposed role in retrograde transport of phospholipid and therefore with maintaining the integrity of the OM as a protective barrier.	8.82466e-50
NZ_CP042994.1\|WP_002049699.1\|453224_454238_-\|magnesium-transporter	gnl\|CDD\|213369	cd12835, EcCorA-like_1, Escherichia coli Mg2+ transporter CorA_like subgroup. A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.35178e-133
NZ_CP042994.1\|WP_031982353.1\|441435_442224_-\|shikimate-dehydrogenase	gnl\|CDD\|234703	PRK00258, aroE, shikimate 5-dehydrogenase; Reviewed.	3.4596e-116
NZ_CP042994.1\|WP_002052337.1\|446411_447242_+\|inositol-monophosphatase	gnl\|CDD\|238817	cd01639, IMPase, IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled into inositol lipids; in eukaryotes IMPase plays a vital role in intracellular signaling. IMPase is one of the proposed targets of Li+ therapy in manic-depressive illness. This family contains some bacterial members of the inositol monophosphatase family classified as SuhB-like. E. coli SuhB has been suggested to participate in posstranscriptional control of gene expression, and its inositol monophosphatase activity doesn't appear to be sufficient for its cellular function. It has been proposed, that SuhB plays a role in the biosynthesis of phosphatidylinositol in mycobacteria.	5.12795e-113
NZ_CP042994.1\|WP_004711782.1\|449908_450727_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213228	cd03261, ABC_Org_Solvent_Resistant, ATP-binding cassette transport system involved in resistant to organic solvents. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.30842e-138
NZ_CP042994.1\|WP_077163789.1\|452257_452851_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|377516	pfam05494, MlaC, MlaC protein. MlaC is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. This family of proteins is involved in toluene tolerance, which is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid compositions, exclusion of toluene from the cell membrane, and removal of intracellular toluene by degradation. Many proteins are involved in these processes.	1.25916e-40
NZ_CP042994.1\|WP_002049746.1\|454395_454977_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	5.13136e-62
NZ_CP042994.1\|WP_004884612.1\|436964_438788_-\|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein	gnl\|CDD\|185635	PTZ00456, PTZ00456, acyl-CoA dehydrogenase; Provisional.	0
NZ_CP042994.1\|WP_148356638.1\|455395_456031_-\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	4.75514e-32
NZ_CP042994.1\|WP_000250997.1\|452862_453150_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	9.2231e-07
NZ_CP042994.1\|WP_031982352.1\|442401_443352_-\|oxygen-dependent-coproporphyrinogen-oxidase	gnl\|CDD\|235413	PRK05330, PRK05330, oxygen-dependent coproporphyrinogen oxidase.	0

>NZ_CP042994.1|WP_002052337.1|446411_447242_+|inositol-monophosphatase
MEPMVVMAARAAQTVGQELLKAHQNRHKLDLQVEEKGIDGPVTRVDRYLEQLTIDTLRKSYKNHSFLGEEFGLQEGKGHDADWCWVIDPLDGTQNFINGFPHFCISIAVQHKGVTQHGVIYDPVRDELFSASRGRGAVMNQRRIRVNVKDSLENTFLAVGHPYRAKRAGEIVSYAEQHFASLLAVTQAGAQIRRGGSAALDLAYVAAGRFDGFFELGLKPWDIAAGELIIKEAGGVVVDARGGNDSLENGQVLACSLKMLKPLMQTVVPAWDKAAK
>NZ_CP042994.1|WP_032011495.1|444385_446290_+|1-deoxy-D-xylulose-5-phosphate-synthase
MLYTEIPTQRPVTPLLDAIDHPQQLRQLEHSQLVQVADELRQYILYAAGQSGGHFGANLGVVELTVALHYCFNTPNDRLVWDVGHQAYPHKILTGRREQITTIRSKNGLAAFPAREESVFDTFGVGHSSTAISAGLGMSLARRYQNDPCEVVCIVGDGAMTAGMAFEAMNDAVAHDADLIVVLNDNDMSISCSTGGFAKHLAAIWEKGHLVNVNEHGEAYIQPHPKWTYNSRLHQSATDAADNLFKAIGFDYFGPFDGHDVNQLVQVFNALKKRKGPRLVHVYTKKGKGFAPAEADPITYHAIGKINATSGGKAPPKYSDVFGEWLCDEAAQDERLLAITPAMCEGSGMVKFAKQFPQRFFDVAIAEQHAVTLAAGMACEGLKPVVAIYSTFLQRGYDQLIHDVALQNLDVTFGIDRAGLVGEDGPTHAGAYDYAYMRTVPNMVIMAPKDENECRQMLHTAYAYNGPAAVRYPRGAGVGVEIQKEMTVLELGKAEIVAEIKPNSDEQITVLAFGSRVMVAIEAAEQLAQKHDVGVRVVNMRFVKPLDEQMIRDLAEHTHLFVTVEEHAIMGGAGSAVNEFMAQEQIVKPIINLGLPDSFLHQASHNQMLQDCGLDAKGILNSIERAWLKQNQVV
>NZ_CP042994.1|WP_001121170.1|443479_444082_-|GTP-cyclohydrolase-II
MPIEFIATSKLPTAFGEFNISVFQDPATGEEHVALSKGLENPPTGPVLVRVHSECLTGDAFASLKCDCGPQLQATQKLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLPADARRYDMCSIMLDHLKVKEVKLITNNPLKIQALKDQGINVVDRVPLTVGRNPFNEQYLKTKRERMDHLYQKDDF
>NZ_CP042994.1|WP_031982352.1|442401_443352_-|oxygen-dependent-coproporphyrinogen-oxidase
MQHPTSTDIQRVREFLLDLQARICAGLEQQEKAGGGTAEFIIDDWERPEGGGGRSRVLQNGTVIEKGGVMFSHINISKLPASATERHPQIAGAKAQALGVSLVIHPKNPNIPTSHANVRLFVAEREGQEPIWWFGGGFDLTPFYPDDQDVLNWHQAAYDLCKPFGDNVYAEHKQWCDDYFYLKHRDEQRGVGGLFFDDLNCWDFETCFKYIQAVGNGYLNAILPIFEKHREQPYTEAQREFQLYRRGRYVEYNLVYDRGTLFGLQTGGRIESILVSLPNLAAWSYRPEWDEDSPEKRLTDYYLKPRDWLGLKEKVA
>NZ_CP042994.1|WP_031982353.1|441435_442224_-|shikimate-dehydrogenase
MTKQFAVIGNPIEQSRSPELHHAFAQKTGVDLNYQKRLAPLDGFESSMRSFFAEGGSGMNVTVPFKEQAFALCDVLTERAQIAKAVNTLWMENGKLHGDNTDGQGLVAAIQALDWNLENTTILILGAGGATRGVIYPLVQAGAKKIVIANRTLARAEQLVDDLKTAVPQAQLQAISLNDLDGDFDIVINATSASLSGGALQLPEKLQFKYAYEMAYGKPSSFLDQAKQRNVPYAEGFGMLVGQAIEAFYIWNGVRPELKDFL
>NZ_CP042994.1|WP_148356637.1|439045_441388_+|hypothetical-protein
MHLKYLSLCLFSLGLTACAQHGVRPQVASANLEQKAIQSVNAMYEYPSYDYRGNFKITVDPSQIKQNGKAENSPKLDAELQKKVDQYLGEQKVGLSKAQKQTLYAAIANEQGGLGPSARSEKVNAVLINLLNDLQFSYDGSIHYRQKMGSFNLTAKYEKPTLLVQAKLPMVLDLENYKFYVNYFGLMPYLVNKENQNNLAYIDFSKYKDFFKNVDTKKFIEYLKASSAVSYRLADPQNLQRVSLTETDRKAGAVDKIRLKTTIEELLLEVELYGQVNDKYLQKSVLGFDNQKMAEKVAKELAASEAKKDAVNKEEQKVSSDDAAAVSQELYSLINAHFDGGLSSNDAGEDNLTTAAQAPAAADASVSENQNGSEEAAAGGVQDAQGEDAVTLTEDQCIELKSLKKPVALGDINYCQVYGIDVLDQSAASAEKVQTKSRRDTLKQTFEAYNQNQFINDEAFKALWLKHKAEIEQALPKQRNPITIDVALDDKGRAVNMTYDVAYTPAEFKHSFNIKADMQILNYGKATSIDQKQLKQAKSVAEASKGSMLENFIKGFGEKLGQGDVLEHPVGTHSDVQDLDANLAVLADKTYDEMHAYDKTYKAVFIAKLTAEKPSYIKYYSVQQLQEIAEVYAYWFSEEDTYNPQGKALERITALQKKHHLEQDEQFDHELGRAVDHIVIETMQGKAGREAWQKLQKQYKQPAQLFSKQYQLEFEKQNGVSAEEKHLLSETADILGNVYVAARKQQLTEKTIQKLKPEHNEFIDYEIFRDVYKQMVAAKK
>NZ_CP042994.1|WP_004884612.1|436964_438788_-|acyl-CoA-dehydrogenase-C-terminal-domain-containing-protein
MPAYKAPLHDIRFLMNEVLDYPAHYKTLSNGESADPDTVDMILEGAADYCENVLSPLNQSGDEEGCHFDNGEVKTPKGFKEAYDQFVMGGWQGLSYPEEFGGQGLPMSLNLIKSEMMGTANWSFTMYPGLSSGCMNTILQFGTDEQKQTYMPKLVEGTWSGTMCLTEPQCGTDLGQVKTKAEPQADGTYKISGTKIFISAGEHDLTENIIHIVLARLPDAPAGTRGISLFIVPKFIPTADGGVGERNTVSCGSIEHKMGIRASATAVLNFDNATGYLIGEVNKGLHAMFTFMNTARIGTAVQGIAHAELSFQGALPYAKERMSMRALSGKKDPDKVADAIIHHADVRRMLLTQKAIAEGGRSMIYYAAQLADKMTDALTRGDQAAFEDYDDKLGFYTPILKGFLTELGLEAANHGMQVYGGHGYIKEWGMEQIVRDARISTLYEGTTGVQALDLIGRKVLLSSKGKVVREYTAEILKFCATHARNKYLRRFAWDLTKLCAQWNTLTVRIMLAARKDRDIVSSASVDFLMFSGYVMMAYFWAQQAVVASEKLEAGDGKETPEFYKAKIKVADFYFDRLLPRAQGHAESMVTTSRTLTSLPVEHFSFDY
>NZ_CP042994.1|WP_016803860.1|436245_436893_+|hypothetical-protein
MSLKWSGLLIKHLGLAAILCMALSACDANHADSKDHSALATTSKHDNSLVKSTTAVKTLDDAAGRTFLPDGAPDQTSKISESDQQYAGRYHTRISCEDNFADCETGEAEYILNLLPDGTAYWNVVHFGRISNKDGAKSAVINRLCPSLKWKVDSAAHELKIQCPTSDVNFYFNIISKQKLIVNLEKLFYSDYGKNREFLEQNYFVPTKAYVLNKE
>NZ_CP042994.1|WP_002052345.1|435739_435994_-|PspC-domain-containing-protein
MTNSGLYRSNRQSMIAGVMGGIAERFGWNANLLRIIFVLVSVMSAAFPGILVYLVLWLVIPKRQPEQVQGYQQPVRTVREEQIH
>NZ_CP042994.1|WP_039246232.1|434569_435670_+|HPP-family-protein
MSVIQPEWLQILKPNFKVLPLKERLLCGVGALCGLAISSLISWYVLGGINAWYIAPMGASSVLLFAVSTSPLAQPWNVIVGNTLAAIIGVACAQYIPDLTTAFSVAVGLAIFLMMTTDSLHPPSGAVAITAVLGGAAIYKLGFYFVFYPVLLNSLLLLGFAIFFNRLIGRHYPVTAHLNERSKDPTPTQKVSIQPKDIEYALEHHTELLDISQYDLEKIILEAQEHANERMVNQYACQDIMSRDVIKLHEDDDIHQALDKFKQVNLMSLPVVNAENHLVGTLALYEVVEWFKGAADPRNSWQHYVKQIMSRRVVTVLPTQPIQDLVPYFVEKSFNYIPVVEERKLIGIISRADMIAALQQQLNRKL
>NZ_CP042994.1|WP_004711782.1|449908_450727_+|ABC-transporter-ATP-binding-protein
MNNKTPLSTQSLIEVKNLSFNRGERVIYDNISLNIRRGQITAIMGPSGTGKTTLLRLIGGQLVPDHGEVLLDGKDIAQMSRQELFAARARMGMLFQSGALFTDMSVYENVAFPIRAHTKLSENLIAELVALKLESVGLRGTEQLMPTELSGGMNRRVALARAIALDPDLIMYDEPFAGQDPIVKGVLTRLIRSLREALDLTTIIVSHDVPETLSIADYIYVVAEGKIQGEGTPEELQKYASPFVKQFLTGSAEGPVEYQFSHQAYLDNEVRP
>NZ_CP042994.1|WP_001091949.1|450723_451500_+|lipid-asymmetry-maintenance-ABC-transporter-permease-subunit-MlaE
MNTIAWLGRLVIERIRGIGVAALMLLQIIFSLPSAGGFGRFVYQMHRVGVMSLLIITVSGLFIGLVLGLQGYSILVNVGSESMLGTMVSLTLLRELAPVVAALLFAGRAGSALTAEIGSMKQSEQLASMEMIGVDPLKQIVSPRLWAGIVSLPMLTVIFAAIGIVGGKLVGVDFLGVDEGSFWSGMQNNVQFGHDVVNGIIKSIVFALLCTWIAVFQGYACDPTPEGIATAMTRTVVYSSLCVLGFDFVLTAVMFGGI
>NZ_CP042994.1|WP_002049738.1|451499_452183_+|outer-membrane-lipid-asymmetry-maintenance-protein-MlaD
MKSRTSELAVGIFVIIFGIALFFLAMKVSGLVGTNLSEGYTMKAQFDNVNGLKPRAKVTMSGVTIGRVDSITLDPVTRLATVTFDLDGKLTSFNAEQLKEVQKNALDELRYSSDYTQATPAQQKTMEQQLISNMSSITSIDEDAYIMVATNGLLGEKYLKIVPGGGLNYLKRGDTISNTQGTMDLEDLISKFITGGGAGKVAAGSSSSAEEKAPASTDSSAQPSFVE
>NZ_CP042994.1|WP_077163789.1|452257_452851_+|ABC-transporter-substrate-binding-protein
MIAGTAFAAPSEAPPDFIKRVADGLIARLKTDHAKLQNNPALVKSIIRQNLDPYVDSQAFTRIVMGTYATNQYSTAAQRAQFETNFRNTLIENYGSAFAKYTNQTYTMRPYKATAGKNPVVTLDFNHNGDKIPVSFQLADKGSQWKIRNINVSGIDLGLQFRNQFAATVKRNGGDLNKAIATFQPDADAAVNQNKQK
>NZ_CP042994.1|WP_000250997.1|452862_453150_+|STAS-domain-containing-protein
MVQYLNQELVVSGKIDFENAEQQYQAGLAIIKKQTSFPLIVDLKQLEHGNTLALAVLVQWLRQTPQKSGLHFKNVPEKMLKIIQACHLQEDLHLV
>NZ_CP042994.1|WP_002049699.1|453224_454238_-|magnesium-transporter
MLEAFYATERGSLEDATINGGFDLHPELVWLDLIAPSQEEQQWVLDAYDQNLPTLKSLEDISSSARFYRDDDGILHISTYFLTKNKNYQVDGDAEDSSHMLAMVQTVAFILHKDRLFTLRGEKLVAFRAFRARARRNDYEMDYKDPTWILLGLLEAKLDELADILEDIHKDLEKYSTEVLNNHQREKILDLDDMITRLAQQEDMLGKAQLCLIDLRRVLTFLSRPRALGSHIYDADIRELSEDVRSLVEHDAFLFQKVRFLLDTTSGFINTEQNDTIRRFSILPSMLAPPMLIASIYGMNTEVLPFAHGKSSFIAVLLIIIGFFIGPIIYFRWKKWI
>NZ_CP042994.1|WP_002049746.1|454395_454977_+|TIGR00730-family-Rossman-fold-protein
MNSICIFCGSSLGSDPIFQQIAQLTGQTIAKQGKTLVYGGGRSGLMGVVADSALQAGGQVIGVIPRALVDRELAHPGLTRLYVVENMHERKTKMADLSDGFIALPGGAGTLEEIFEQWTWAQLGIHQKPCAFLNVAGFYEDLLKMVQGTVDKGFSQARFADKLIASDKIEDILQQFEQYQPPAPKWTNADVQP
>NZ_CP042994.1|WP_006582595.1|454991_455393_+|NUDIX-domain-containing-protein
MKTITVAAAVILNEQNELLLVRKRNTQAFMQVGGKLEPNEAPETAIQREILEEIGSPCVIERFIGRFETAAANEPDHTLISHLYLVRLKQSPQIAAEIAEMKWIKFNDSETKLAPLTKEIVIPWCEQNLSTTL
>NZ_CP042994.1|WP_148356638.1|455395_456031_-|ComF-family-protein
MFKLFNPQYLFQLLSPCLLCEIGTREKYSLCKECWEQLPWLKQTVQRNDQSILVACHYAYPINRIIQQYKYEQKLHYQTLLAEVLQQIKFPKVQAIVPMPISKQRLTERGFNQSLLLAKLLSKQLKIPVWQPVQRLNERSQKGLSRLERFENIEQQFVAMTQEKRRYRRVLIIDDVITTGSSIHALSQALKQLGCTSIYASCLAAASSTSY
>NZ_CP042994.1|WP_148356639.1|456023_458069_-|ATP-dependent-DNA-helicase-RecG
MTSVHQLQGVGSASAALLEKLNIFTTDDLLFHLPRDYEDRSTIIPMNQLVVGRSYLLEGEVKSVDFPPGKRKSMAALIQDEFGKVTLRFYHIYKNLTDKIKPGNRLRIFGEVRVGARGLELYHPEIQLINEHTLLPKTQLTAIYPSTDGLTQPKLREYVKQALKHHSDALPELLPKQYTNGYALKEALHYIHEPPVDANMIQLAQGSHPAQQRLIFEELVAHQISLLTRRAYIRQIASPAFPSSKVLAKKLLEALPFQMTNAQKRVSKEILIDLKQHQPMLRLVQGDVGAGKTLVAAVAACHALEADWQVALMAPTEILAEQHYLNFKRWFEPLGITVAWLSGKQKGKARTQAEQQIKEGHAELIVGTHALFQDNVEFAKLGLVIIDEQHRFGVDQRLALRNKGAEQLTPHQLVMTATPIPRTLAMSAYGDLDTSIIDELPPGRTPIQTVTIPLDRREEVLNRIATNCREGKQAYWVCTLVEQSETLDAQAAEATYQEMKERFPELNIGLVHGKMKADEKQSVMQSFKNNELQLLIATTVIEVGVDVPNASIMVIENAERLGLSQLHQLRGRVGRGAKASFCVLLYKPPLSQNGQERLSILRESNDGFVIAEKDLELRGPGELLGTKQTGDMGFRVARLERDDHLLSQAHYVAQQVLKDYPEQADALLKRWLPEAPRYAYV

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Crispr_ID: NZ_CP042994_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042994_2

502173-502484

Orphan

Consensus_repeat	Method
ACCACCGATNATNTCAGTCACAGT	CRT

5 spacers

The CRISPR arrays of NZ_CP042994_2

>merge|NZ_CP042994|2|502173-502484|CRT
ACCACCGATGATGTCAGTCACAGTACCAAGCGGGTTGCCGCCAGTAGCGCCACCAGTTAAACCACCGATAATGTCAGTCACAGTACCAAGAGGATTACCGCCCGTCACACCACCGATAATGTCAGTCACAGTGCCAAGAGGGTTACCACCAGTAACACCACCAGTTAAACCACCGATAATGTCAGTCACAGTGCCAAGAGGGTTACCACCAGTAACACCACCAGTTAAACCACCGATGATATCAGTCACAGTACCAAGCGGGTTACCGCCAGTAGCGCCACCAGTTAAACCACCGATGATATCAGTCACAGT

>NZ_CP042994|2|1|502173-502484|CRT
ACCACCGATGATGTCAGTCACAGT	ACCAAGCGGGTTGCCGCCAGTAGCGCCACCAGTTAA
ACCACCGATAATGTCAGTCACAGT	ACCAAGAGGATTACCGCCCGTCAC
ACCACCGATAATGTCAGTCACAGT	GCCAAGAGGGTTACCACCAGTAACACCACCAGTTAA
ACCACCGATAATGTCAGTCACAGT	GCCAAGAGGGTTACCACCAGTAACACCACCAGTTAA
ACCACCGATGATATCAGTCACAGT	ACCAAGCGGGTTACCGCCAGTAGCGCCACCAGTTAA
ACCACCGATGATATCAGTCACAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042994.1\|WP_106479807.1\|510507_511131_+\|NAD(P)H:quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|179647
NZ_CP042994.1\|WP_022576134.1\|512703_513375_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_004711840.1\|504995_505688_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
NZ_CP042994.1\|WP_002049690.1\|490524_491610_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_002050751.1\|509000_510248_-\|YihY-family-inner-membrane-protein	unknown	unknown	gnl\|CDD\|179313
NZ_CP042994.1\|WP_151276929.1\|489115_489361_+\|succinate-dehydrogenase-assembly-factor-2	unknown	unknown	gnl\|CDD\|377166
NZ_CP042994.1\|WP_002049754.1\|495233_495443_-\|YheV-family-putative-metal-binding-protein	unknown	unknown	gnl\|CDD\|312883
NZ_CP042994.1\|WP_006582613.1\|508065_508980_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP042994.1\|WP_006580689.1\|492447_494643_+\|TRAP-transporter-large-permease-subunit	unknown	unknown	gnl\|CDD\|224509
NZ_CP042994.1\|WP_004711824.1\|491693_492260_+\|rhombosortase	unknown	unknown	gnl\|CDD\|274845
NZ_CP042994.1\|WP_032011514.1\|489367_489757_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_080631584.1\|497671_500107_-\|ribonuclease-R	unknown	unknown	gnl\|CDD\|273947
NZ_CP042994.1\|WP_002050789.1\|511185_511761_-\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
NZ_CP042994.1\|WP_032011515.1\|495483_497538_-\|M3-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341051
NZ_CP042994.1\|WP_022575950.1\|494790_495222_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_006582612.1\|507165_507960_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380379
NZ_CP042994.1\|WP_032012174.1\|511832_512546_-\|DUF3108-domain-containing-protein	unknown	unknown	gnl\|CDD\|378635
NZ_CP042994.1\|WP_004711841.1\|505911_506409_+\|YcxB-family-protein	unknown	unknown	gnl\|CDD\|379553
NZ_CP042994.1\|WP_032012172.1\|506448_507090_+\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|182650
NZ_CP042994.1\|WP_017392652.1\|500753_501347_+\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|319796

Protein	Function_ID	Function_description	E-value
NZ_CP042994.1\|WP_004711840.1\|504995_505688_-\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	7.52151e-107
NZ_CP042994.1\|WP_032011515.1\|495483_497538_-\|M3-family-metallopeptidase	gnl\|CDD\|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NZ_CP042994.1\|WP_002050751.1\|509000_510248_-\|YihY-family-inner-membrane-protein	gnl\|CDD\|179313	PRK01637, PRK01637, virulence factor BrkB family protein.	1.23999e-74
NZ_CP042994.1\|WP_151276929.1\|489115_489361_+\|succinate-dehydrogenase-assembly-factor-2	gnl\|CDD\|377166	pfam03937, Sdh5, Flavinator of succinate dehydrogenase. This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans. Bacterial homologs of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterized as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria. This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true. The E. coli protein, YgfY also acts as the antitoxin to the membrane-bound toxin family Cpta, pfam13166, whose E. coli member YgfX, expressed from the same operon as YgfY.	1.30659e-15
NZ_CP042994.1\|WP_002049754.1\|495233_495443_-\|YheV-family-putative-metal-binding-protein	gnl\|CDD\|312883	pfam09526, DUF2387, Probable metal-binding protein (DUF2387). Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.	5.43918e-16
NZ_CP042994.1\|WP_006582613.1\|508065_508980_+\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.84784e-12
NZ_CP042994.1\|WP_006580689.1\|492447_494643_+\|TRAP-transporter-large-permease-subunit	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	2.17433e-15
NZ_CP042994.1\|WP_004711824.1\|491693_492260_+\|rhombosortase	gnl\|CDD\|274845	TIGR03902, hypothetical_protein, rhomboid family GlyGly-CTERM serine protease. This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.	1.72704e-46
NZ_CP042994.1\|WP_080631584.1\|497671_500107_-\|ribonuclease-R	gnl\|CDD\|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NZ_CP042994.1\|WP_002050789.1\|511185_511761_-\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	3.00055e-124
NZ_CP042994.1\|WP_106479807.1\|510507_511131_+\|NAD(P)H:quinone-oxidoreductase	gnl\|CDD\|179647	PRK03767, PRK03767, NAD(P)H:quinone oxidoreductase; Provisional.	1.06805e-59
NZ_CP042994.1\|WP_006582612.1\|507165_507960_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	6.63724e-24
NZ_CP042994.1\|WP_032012174.1\|511832_512546_-\|DUF3108-domain-containing-protein	gnl\|CDD\|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA\|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	9.52967e-18
NZ_CP042994.1\|WP_004711841.1\|505911_506409_+\|YcxB-family-protein	gnl\|CDD\|379553	pfam14317, YcxB, YcxB-like protein. The YcxB-like protein family includes the B. subtilis YcxB protein, which is a functionally uncharacterized transmembrane protein. This family of proteins is found in bacteria, and is approximately 60 amino acids in length.	0.000230978
NZ_CP042994.1\|WP_032012172.1\|506448_507090_+\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|182650	PRK10691, PRK10691, fumarylacetoacetate hydrolase family protein.	5.29722e-65
NZ_CP042994.1\|WP_017392652.1\|500753_501347_+\|HAD-IB-family-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.20595e-43

>NZ_CP042994.1|WP_017392652.1|500753_501347_+|HAD-IB-family-hydrolase
MNLALFDFDGTITHNDTFSLFLKFSLSRKTQILGGLRLAPYIAGYKFGWVTDKTIRIKLCQVGYIGYDANSLKYMGQEFAKTVIPTCIRENALERIHWHKQQGDQVVVVSASLGVYLESWCQSLDLDVICNQLEIDNGILTGNFINGDCGYLEKVNRIKNKYDLTQYSTIYAYGDTPNDYAMLELAHKKYYRWQEMN
>NZ_CP042994.1|WP_080631584.1|497671_500107_-|ribonuclease-R
MKPKDMTKNWADPEAKAEAERYDNPIPSRTLILDTLEQLQTPQSHAELVDHFHIQDQKSIEALSHRLSAMVRDGQIMKEGFKFQLVADQPTYEATVYINSKGLGTAHIDGQDDLLLPERELRLVFNGDRVRVRQTSVDRKGKPWGFITEVLQHRVKQLIGKLSIHEGEYFIQPNNPNQHQPIPLEKELVAHAKANVGDMLRVAIDTYPTREEFATAHIIQSMADKADTEIIIPQTILEFGLPYEFPDEVIKEAESFKEPSAQDREGRVDLRDLALVTIDGEDARDFDDAVYAEKRPGGGYRVVVAIADVSHYVRLGSALNEEAEERGTSVYFPHFVLPMLPEALSNGLCSLNPHVDRLCMVCDLKLSRTGRVTGYEFYPSVMHSKARLTYTQVAQYFDGATDAIPKDRDIHKSLNTLFQLYQILKNLRADRHAMEFETIETYMTFDELGGIKEILPRTRNEAHKLIEECMLLANVAAAEYALEHDIPMLYRVHEAPEFSRIQKVKDFVKLLGLPFPDQPTQADYQKVIEATKDRIDAPSIHAVLLRSMMQAYYGAKNAGHYGLAYEAYTHFTSPIRRYPDLLLHRAIKAHLKQKPYPLSGAALDDAGEHFSQTERRADEASRSVTTWLKCHYMQQHLGDEFIGIVSAVTEFGLFVTLKDLYVDGMIHISQLGDDFFIYDQASQNLIGQNRGQVFGLGDEVKIQVAGVNLEERKIDFQLIQQVTHAGRVVRSRAPRTTRTAAQATEEVFGKPSTPSNDGEKPVRKKKEKGKPSSYSKKSGKKTSTKAEAKPEKVKKKAKPKKKKSNAKSKAD
>NZ_CP042994.1|WP_032011515.1|495483_497538_-|M3-family-metallopeptidase
MWLLAMTLQQATLPTPRFDQITLDNLKQDIQQAIQAGQEFLNTLTAAPSETNQQLAVLEQIDALENNLSESWGVLSHLNAVMSNAETREVYQSLLPALSEYYTQLGQHTALYQTYQHIHDGQSYSTLSPAKQSAIRLALRDFKLSGVALEGEEKKRYAEISARLSQLSSDFSNHVLDATQAYFKPLTEDQLKGLPESNVELLKQYGKQRELDQAVATLDFPAYFAIMTYADDRTLREELYKAYVTRASDQSEQTEFDNSKIMEEILSLRQEMAKLLGFNNYAEYSLASKMAPDVKTVHDFLADLAEHARTPALQEVAELQAIAKQDGIDELKPWDTTYYSEKLKQQQFNLSQEALKPYFPAPKVIQGLFQIVQRLYGINIVEREAPVWHPDARYFELEDQGQVIGGFYFDLYARTGKRGGAWMSGFRSRMQTVHGLQKPICYMVCNFTPPVGNQPALLTHDEVITLFHEFGHGLHHMLTEVDNISVAGTHGVAWDAVELPSQFMEFWSWDKESLDVLSEHIESKQTLPQELLDALLNARFFQSGMQTLRQLEFALFDLTIHTKTPALNSEQIQQTLDDIRKQYAVVPTVEYNRFQHSFSHIFAGGYAAGYYSYKWAEVLASDAFDRFENEGIFNTQTGKEFRQAILAVGGKDTALEAFVNFRGREPKIDALLRHQGWTNDNKTA
>NZ_CP042994.1|WP_002049754.1|495233_495443_-|YheV-family-putative-metal-binding-protein
MKKRFIAGAKCPKCEAIDRIVMLTTAEDEWIECIECGYSENRPTHVDEPETPAIPDEVGVIQFKPRRSD
>NZ_CP042994.1|WP_022575950.1|494790_495222_-|hypothetical-protein
MPLQRKQNSKLLWILIGGLSILVVLFFAAQWFFKKTESSAPMVDPQPASTPVPQKTTQPSASSEPVAQTHTANSQQLVNEDVLKQPVPAQESLAKEEVSKLNDIHQQLQDQEATLKAQHADADQLIKLKEEQVKLLEAQVKQQ
>NZ_CP042994.1|WP_006580689.1|492447_494643_+|TRAP-transporter-large-permease-subunit
MQEYQEKRSGLGLLGYVWNEWISTFVILILLLMTLIIGTGEMIHGQLLRIGERLYGDPASGMQYSFLRAEPEKPSCDRHPNIDAQVKEQMKANASDDFASFFGAASESDVRASLLAAQQQCEDKYLAYDKTIKYIEAHPGVRTYRTIETGFFGIFKFGTENRAILLVFMVLISAITASLKFHHIGLRNPATKLDYKVYAFFMLLGNALLSSSVISQYRSVINSGVSPTHETIIIYWLWMILFVILTLISLYQLFVSPAPKREGGNIGLALLCVPLYAYMAVITGVAFTFFMDYPMGQGIYLGQLVEFSGIFLNLALFIWAGMLLTQTRVMDLFLNVLRPWNLAPETLTWLILIAAAVPTAYTGASGIFVIAAGAIIYKEVWNAGARRQYALAVSAMSGSLGVVVRPCLLVVLIAMLDSRHVTSDELFGHGIYVFWLTAFIFLGVSLFLAEEKFRVNSPKVALPGMARAFVPVIPYILITVVVLAFYKYALDTGMNEFTAPVILPLVLIAMILYDKMVMPKEAPALNIHEAIVREHEKKSPFLQSHDPHSSQFRLGFGGALRFATSETVGHIGALIILMALSASVGGLIERTEIVEMLPTHLGNIYISLAFIALLLAIIGMCTDPFGAVILVAATIAPVAYENGIHPIHFWMIVLVAFEFGYVTPPVALNHLLTRLSVGDDEVNAADAEAKEKYTSFYYRYERWLLPIIVLFSSLVLVTYAPLVLKLFGWYQ
>NZ_CP042994.1|WP_004711824.1|491693_492260_+|rhombosortase
MKDHVLNKKVLLVAGCISVSACLQVFPDYFIYWRESLLGEFWRLWTAHWVHVGWIHFLLNMMAFACLPFIFPHTKVWHILSLLFLLPPFISLVFYFYLPYIDAYAGLSGVLHGLYTAVALVYLQYRKERNFALLVLGLIIAKLIWENTFGQTGTAQLIGSPVLTEAHLYGAIGGAIFGGCYWLIQRFK
>NZ_CP042994.1|WP_002049690.1|490524_491610_+|hypothetical-protein
MSKVQKISQGLAMSFLAASVLSGCSYVVKSGANVALGFTEKHVVPPILAMQDAEMVCNTGSALTPAIMSTKGMGADPTRVAVLMYAASGVCAENQALEQELRYLRASKAGQVTEAQDARIAQKRWAAIAAERQYTGYKLFADRWESKYKYHLGDSCPTMRSDTDQTVYLLGMISGLQAVTNDINSGGSVNVPKDIAAIVERGMVCLDNQKFWGAPNATRAVIWTLLPGANEGKPDPYETLKQSVQIGEQKGVRLSHALYAVAAQASGDDAKIRDALKTYAASQADDKPVNPNFKLIDSMAGLIVRGISDRYWTEHTGVRTGDGGMSHFWDEKNEGSAELDELFDGGAASEVPADSTTAPAQ
>NZ_CP042994.1|WP_032011514.1|489367_489757_+|hypothetical-protein
MDSHLNFKLKYSRFAIIFQFFIGLNLVVLFYQLLPILWWLVTVSLLFISFIFFLKRPQLAQIAHLDQKLWSLSFHSEQTISRVEILKIIDYQIFIVVYFEGHKTLTSVIWFDQMPLSQWKQLKTLEKFY
>NZ_CP042994.1|WP_151276929.1|489115_489361_+|succinate-dehydrogenase-assembly-factor-2
MTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLKHYVHG
>NZ_CP042994.1|WP_004711840.1|504995_505688_-|nitroreductase-family-protein
MSFFAKLFGLNQKTTAQEDVALKAAQELESSNETSFIELIKNRRSIYAIGNNLSQSNDEIEKLIQEAIRHSPSAFNSQSSRAVILFGQSHHKFWDTVLEVLKSIVPAEAVSGTEQKIQSFAAGAGTVLFYEDQNVVKGLQEQFAAYADNFPIWSEHSTAIAQFAVWNILTEQGIGASLQHYNPIIDEKINVLFNIPSEWKLRAQLVFGSIEAKAGEKTFIDDESRFKTFG
>NZ_CP042994.1|WP_004711841.1|505911_506409_+|YcxB-family-protein
MTEQKSALSLRYYLNLEESQDGFGLVTFGKKQFTRFLTPVISIAIVIWGFYLGLSGVGRYYVALGIFFLIMQGLMRYWLLPMMFKRQFVRYQFGKSEQGIDLYQDYFELYAAGRKQVVQYGDVQTFAKGKLTYMLELKNKTVIIVPKRAFAQASDQTIFENTFKK
>NZ_CP042994.1|WP_032012172.1|506448_507090_+|fumarylacetoacetate-hydrolase-family-protein
MKTRPSKIVCVGRSYADHVKELNNAMPGRPVLFIKPPSSLIGLDEGISWNPAWGSCHFECEFVLRIDQPLKGETDPQKVLQAIGAVTLGLDLTLRDLQNELKDKGQPWERAKAFDGSCVLADWVDVSEITNWEETKFTFHINDELRQDGNTALLMFNIANLLTDINQVFALEPGDVIMTGTPAGVGPLHAGDQLKMTLKGATQDFIWETFVKA
>NZ_CP042994.1|WP_006582612.1|507165_507960_-|helix-turn-helix-transcriptional-regulator
MKKSAQRVQDFQEIPAHNAIPDLLWFRVRNAPAETIYPQHAHAWGEFIYAFSGVLEVNIDQINYLTPPPYGIWLPPYTKHSGINRNQVTHATLYVHESLCQKLPQKAGILLTSPLVPALLDHLRQNPQDETRVEYIRLLQVLLDQLIQAELVGSYLPTTNHPALAKILNDLHQCPADNSTLQELAERNNMTERTLARYSQKELGMSLHEWRQRLKVMKAMTMLNQGKTIESIAFDLGYASASAFIYMFKRWMGFTPDQFRKLYQ
>NZ_CP042994.1|WP_006582613.1|508065_508980_+|DMT-family-transporter
MEERKNLDARASALMVLLCMVLGLQQVVLKIAAPDISPIMQIALRSGLSAVLVLPLLWRDHSIHLFSYQQCKAGALVALFFSLEFYFVTEALKFTSTSHTVVLLYTAPIFVALGLHWRFPTERLNRAQWGGIALAFMGIIITFYPTTTAINAPAIAQVLLGDLYALMAGLAWALSTIIVRLSSLAQAPATQTLFYQLTGCFILLISIAFLTGQTTIHLTALTILSLSFQTLIVSFASLLLWFWLLRNYLASRLGVFSFLTPLFGVLFSVLLLNEKLEIKFIFGSILVLSGIVVMSLKQGQPNKG
>NZ_CP042994.1|WP_002050751.1|509000_510248_-|YihY-family-inner-membrane-protein
MLERFLKRLPFYNKTWFQFILFVIKRFEADRCREQAGSLTYTTLFAVVPMLTVFLVIISSIKALEPARQQLQHLIYSNFLPKSTIAFDKALNAFTEKSSNLTVIGVLFLFVTTVLMLTTIETVFNRIWRVKETRSGIVGFMRYWTIISLGPIILGSAFVISSTVASMNLLSNNFTGYQLDGAFLLWLISFVLTVLGFFILYWTIPNRTVPLFSAAIAACLSAVLFEILKNLFSFVMSNFTSYEIIYGAFAAVPIFLLWVFLSWNIVLLGVEVSFALTAFHSGKEQKRHPVLMLLDILELFYKKQKLGESVSDKEALAILGRGEIGRWPAYVVLLEEQNLVKRTDKDEYVLVRNLSQVDFWSFFTALPYPLPLRPDVLNVHDDDEWMERIGPALVESNDYLAAKLSIPLSTIFEEK
>NZ_CP042994.1|WP_106479807.1|510507_511131_+|NAD(P)H:quinone-oxidoreductase
MFFLTKFMKPMQPYILVLYYSKYGSTKEMAHLIANGVESVGIGVKIRTVPNIATVVTKVEPSIPEEGDIYCTLEDLANCAGLALGSPTRFGNMASEMKYFWDQTTSLWLNGALHDKPACVFTSSGSMHGGQESTLLTMLPPLFHHGMMILGLPNSIPALSNTKTGGTPYGASHVSGPRHDQSLSQDEKLLCEAQGRRLGEVVKKLCL
>NZ_CP042994.1|WP_002050789.1|511185_511761_-|xanthine-phosphoribosyltransferase
MHALEQKILTEGIVLSDQVLKVDAFLNHQIDPVLMQQIGKEFAARFKDAGITKIITIEASGIAPAIMAGLELGVPVIFARKYQSLTLKDDLYRAKVFSFTKQTESTIAISNKHINSSDKALVIDDFLANGQAALGLIDLIHQANAEVVGVGIVIEKSFQPGRDLLLEKGYRVESLARVKSLTDGTVTFVKE
>NZ_CP042994.1|WP_032012174.1|511832_512546_-|DUF3108-domain-containing-protein
MATKFLKSFSIATGISTTLLIASFSSHALAMSPFQANYQFTYNNKGMGSATRALSQQGNNWTYLFTAKAGGIASASETSKFSFTNGKIGSQSFSRTSKILIHNNTMNINFNPGNKTISTKKDDKARTFAWQPGVLDELNAELQVREDLKNGSLKSSYPLADAKEVENRRFVKQGSEKIKTSYGTFDTVKVVLEHGRPDRSTIFWLAPKLDYLPVKVSHIDGKTSYGLLLTSYSGKTN
>NZ_CP042994.1|WP_022576134.1|512703_513375_-|hypothetical-protein
MQTLFSSLVKRLHKVYRKAEAFIEEERDFTLSQTFLNATLERYVTNNVEFLDDLHADLYHDWLRLYATMHVKGLETTLSVDLKLIQMEFNKEQQLIVFEQISNTQIVEAKYKNFWQKIAVKAAIFYYHKILKKDPLGMILERFNVAQEKDDLIFLDLNRWFGKKASIIETLGKVHINYARVREAELVVFGNVNLAALLFRDQEDDFEDDLEDTEITPIQQKDA

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Crispr_ID: NZ_CP042994_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP042994_3

2327825-2327910

Orphan

Consensus_repeat	Method
GTAAATTCATGTGCATTACCACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP042994_3

>merge|NZ_CP042994|3|2327825-2327910|CRISPRCasFinder
GTAAATTCATGTGCATTACCACTAGCGTGTGCAGCTCGACCAGCTTCACGAGCTTCTTCTGAAGTAAATTCATGTGCATTACCACT

>NZ_CP042994|3|2|2327825-2327910|CRISPRCasFinder
GTAAATTCATGTGCATTACCACT	AGCGTGTGCAGCTCGACCAGCTTCACGAGCTTCTTCTGAA
GTAAATTCATGTGCATTACCACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP042994.1\|WP_081404483.1\|2329999_2332144_-\|catalase-HPII	unknown	unknown	gnl\|CDD\|236886
NZ_CP042994.1\|WP_002048358.1\|2335003_2335321_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_032011843.1\|2333921_2334401_+\|CinA-family-protein	unknown	unknown	gnl\|CDD\|224463
NZ_CP042994.1\|WP_032011842.1\|2335390_2335612_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_002048408.1\|2325679_2326291_-\|translesion-error-prone-DNA-polymerase-V-autoproteolytic-subunit	unknown	unknown	gnl\|CDD\|182350
NZ_CP042994.1\|WP_004709384.1\|2329064_2329943_+\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187613
NZ_CP042994.1\|WP_004709372.1\|2326573_2326810_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_004709367.1\|2324384_2324840_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP042994.1\|WP_032011844.1\|2332196_2333606_-\|iron-containing-redox-enzyme-family-protein	unknown	unknown	gnl\|CDD\|379634
NZ_CP042994.1\|WP_001136759.1\|2335699_2336128_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_025466845.1\|2328518_2328923_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_106479431.1\|2322681_2324328_+\|allantoin-permease	unknown	unknown	gnl\|CDD\|224374
NZ_CP042994.1\|WP_032011848.1\|2319051_2322516_-\|response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_CP042994.1\|WP_032011849.1\|2318095_2319055_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|381147
NZ_CP042994.1\|WP_017392947.1\|2317667_2317952_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379642
NZ_CP042994.1\|WP_081404488.1\|2316722_2317358_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP042994.1\|WP_002048336.1\|2336398_2336542_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_081404484.1\|2317446_2317551_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP042994.1\|WP_002048382.1\|2324996_2325608_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP042994.1\|WP_000108365.1\|2334676_2334898_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171

Protein	Function_ID	Function_description	E-value
NZ_CP042994.1\|WP_081404483.1\|2329999_2332144_-\|catalase-HPII	gnl\|CDD\|236886	PRK11249, katE, hydroperoxidase II; Provisional.	0
NZ_CP042994.1\|WP_032011843.1\|2333921_2334401_+\|CinA-family-protein	gnl\|CDD\|224463	COG1546, CinA, Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only].	1.02472e-20
NZ_CP042994.1\|WP_002048408.1\|2325679_2326291_-\|translesion-error-prone-DNA-polymerase-V-autoproteolytic-subunit	gnl\|CDD\|182350	PRK10276, PRK10276, translesion error-prone DNA polymerase V autoproteolytic subunit.	4.11514e-39
NZ_CP042994.1\|WP_081404488.1\|2316722_2317358_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.1794e-63
NZ_CP042994.1\|WP_004709367.1\|2324384_2324840_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	8.95209e-40
NZ_CP042994.1\|WP_000108365.1\|2334676_2334898_+\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	5.30417e-06
NZ_CP042994.1\|WP_106479431.1\|2322681_2324328_+\|allantoin-permease	gnl\|CDD\|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	7.17219e-23
NZ_CP042994.1\|WP_032011848.1\|2319051_2322516_-\|response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	4.12235e-58
NZ_CP042994.1\|WP_032011849.1\|2318095_2319055_-\|response-regulator-transcription-factor	gnl\|CDD\|381147	cd19920, REC_PA4781-like, phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains. Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	5.9823e-55
NZ_CP042994.1\|WP_017392947.1\|2317667_2317952_-\|N-acetyltransferase	gnl\|CDD\|379642	pfam14542, Acetyltransf_CG, GCN5-related N-acetyl-transferase. This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	2.45305e-25
NZ_CP042994.1\|WP_032011844.1\|2332196_2333606_-\|iron-containing-redox-enzyme-family-protein	gnl\|CDD\|379634	pfam14518, Haem_oxygenas_2, Iron-containing redox enzyme. The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase.	4.35686e-18
NZ_CP042994.1\|WP_002048382.1\|2324996_2325608_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.37986e-22
NZ_CP042994.1\|WP_004709384.1\|2329064_2329943_+\|glucose-1-dehydrogenase	gnl\|CDD\|187613	cd05355, SDR_c1, classical (c) SDR, subgroup 1. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	4.48425e-160

>NZ_CP042994.1|WP_004709372.1|2326573_2326810_+|hypothetical-protein
MKNQRDAVLGYANEQHAYYIRLIENDAVLGESYGIFCENPESEAAESIMTTLFLKKSFWINGSEFTDIVKGLHPLTHS
>NZ_CP042994.1|WP_002048408.1|2325679_2326291_-|translesion-error-prone-DNA-polymerase-V-autoproteolytic-subunit
MPKKKEFEHGGARENAGRKAQFNEPTKVIRVPESQVNFIKNWLLNNVKTDNQTDFTSKLKIQQVHPNNDKIYHIPLATERVAAGFPSPAQDDIEQALDLNEYLIRNENATFIVKANSLSMLDAGIDIDDPLIVDRSIPAKSGDIVIALIDNDFTVKRLMIDTQFHPPKVWLKAENPDYQNIYIEDGQELVIWGVVTYNLKRMR
>NZ_CP042994.1|WP_002048382.1|2324996_2325608_+|LysE-family-translocator
MAFNIFIAFWSVSILFIITPGADWAYAISAGIKGKVVVPAVAGMLFGHFITILLVAAGVGLLVANNPTALMILTVAGSAYLLWMGINLLLTPPTPNQSGSEKAQSWLSWATKGVYVSGLNPKVFLLFLALLPQFIDTTASWSVTTQILAFGVVHMISCAIIYLMVGYGSEAILKTRPQAAQLVGRFSGGLMVVIATCLLIGQI
>NZ_CP042994.1|WP_004709367.1|2324384_2324840_-|Lrp/AsnC-family-transcriptional-regulator
MDRTDKKILAELQLNGRLSITELAEKVGLSISPCHRRVKALEESGAIKGYRAELDPNLVGFEFSAIVFITLKEGDKQAVEKFENAVIEIPQIIQAQRLFGEPDYLLHVVAKDLPAFQRLYDEKLSAIPSVQRIISTIVMKDVVPERLFPIG
>NZ_CP042994.1|WP_106479431.1|2322681_2324328_+|allantoin-permease
MTENDWETDVMSVSEHPNLDTVQGTDSQKAVNETLEDYTLRYAPHSFRRWSPKVVAITALGGIAYLADFSIGASIGMSYGTTNAVFSILFAAIIIFLTGIPLAYYAARYNIDLDLITRGAGFGYIGSVLTSIIFASFTFIFFALEGSIMAQGLLLGLGIPLWAGYLISTIMVIPLVIYGMKALSKLQVWTTPLWLVLMIGPVAYLIYQEPTLVSQFATFTGHEGFAPVDMAAIMLGAGICLSLIMQIGEQIDYLRFMPAKTKENSKAWWAAVISAGPGWVILGAIKQIIGAFLGFYLLTKIPGVNSTEPVQQFNAAFHDMLPGWAALTLAVILVVISQIKINVTNAYSGSLAWTSAYTRISKHYPGRIVFVIVNLAIALALMEGNMFAVLGKILGFYSNFAIAWVVVVATDISINKYVLKLSPKEPEYRRDMLYNVNPVGMVAFLVSAGLSIAAFFGLLGSFLAPYSPIIALVLAFVLTPIMGLLTKGKYYIKSHDDGVKEPRYDAEGTPVATVYHCRVCEQGYERPDIMFSHKHNGTICSLCKTLDA
>NZ_CP042994.1|WP_032011848.1|2319051_2322516_-|response-regulator
MSVMPDSSRPQQAPQRVIKTRREYNIWVADESIEDYALRYAPTSVRKWSPWTVTNTAISTVSFLAMEAIGATMLWQYGFSNALWAAVVVCTIIFLTSWPISYYAAKYNVDVDLLTRGAGFGYIGSTITSLIYASFTFILLAFEAAIMAMALELALGIPQVIGYLISALVILPLVVKGIGFINKVQAITQPIWLLLLLLPWFFVLWKQPQILSSSLHFVGAVSNSTDFNLYYFGAACTLIFSFVIQIGEQADYLRFLPQKEKNRTAWRFAVFLGGPSWIIFGFLKVLMGMLLMVLAFQLFIPVSELDNPTYLYWVAYQQFIPNPQLALILTLALVCLAQIKINMTNAYAGSLAWSNFFARLTHSHPGRIVWLLFNVFIAIVLMEMGISHAVERILGLYSNIALAWIGAVVADLIICKPLGLSPKGIEFRRAYLYDINPVGVGALLIASVLSMLSYLGFFGLMAKGLASFIALGSAVLCVPVIAYLTKGKYYIARQPEKIQATSVANCVVCERDYELADMAGCPAYNGTICSLCCSLEARCHDLCKPDARWSVQLKKAIWHYLPERWASRLNSRVSLYLLLTLGLSIVLAVSLSLVYIQEKTYLETINAAAVPQLFTLFVKIYTILFLLMSVAAWWLVLNDESRRNAEIETHQQTALLIDEIAAHEVTSKDLQDARIAAERANDAKSRYVIGISHELRTPLNSILGYSQLLQKQEQLSEQGKMALGVISRSGQHLTSLIDGLLDLARIETGKISLNVVDVHFPNFIEQIIQMFQPQFEQKNLQFVYEIGENLPHYVRTDKKRLEQVLINLLGNALKFTTSGTITLKVEYRFQTAYFEIRDTGCGIAEADLERIFNPFERGSNVVQGGFTGTGLGLPIVKLLVDLLGGQLSVTSQLNQGSQFKIKFYLPSKEVVHPISNVYSNQITGYQGERKRILVVDNEAVDRGLVANFLKPLGFIIEEAESGIDCLRRVPIFQPNLILMDLNMPLMGGWETARLLRQNNITNVPILIISANAGEREVNPQDAVLSEDFMLKPIDLNLLLSKIGDKLGLVWIDSKSETFLENDEVQALDVKVFKQEQAAVHTSITQPENNDLLDLPQSLQQLNDLIGQGYIRGIQQTLMQCRQNFPEHNELWEQLEQAIQKFDLKHAQRLIQDKQ
>NZ_CP042994.1|WP_032011849.1|2318095_2319055_-|response-regulator-transcription-factor
MSTQHVSFQQASPNEQAVILIVDDVPENLGLLHESLDQAGYRVLVTTDGLSAIEIAHRCLPDMILLDGNMPHMDGFESCIQLKASPITQFIPVIFMTGLSETEHIVRGFQVGGVDYVTKPLNIEEVLARVKTHLAHAKLLKQQKQVIDATETAILALDVHGKIVWKTQKASDLLNQYLPELEGFEAGLKAWFSDLEQEKDPKKLTSCSYSTPSQQLQLLLLTPWESEPSVAKNYLIQIKTSTPALEMADILKYCPQLTQREAEVMHWLLLGKTNKDIAEILELSPRTVNKHLEHVFEKLCVENRTAAVAHINSLVQEFH
>NZ_CP042994.1|WP_017392947.1|2317667_2317952_-|N-acetyltransferase
MNIQQKDDTKHGSFSLLDGETVAGEMTYTWAGESMLIIDSTDVNENYRGQGVGRQLLDALVAFVREKDVKVIPLCPYAKSVFDKDPSIGDVLRK
>NZ_CP042994.1|WP_081404484.1|2317446_2317551_+|hypothetical-protein
MCNEFIFFPIGLKLFLLDKLFYKFDKFDLVNENC
>NZ_CP042994.1|WP_081404488.1|2316722_2317358_-|amino-acid-ABC-transporter-permease
MLPQFFSATLTTLKISIISIILAIIVGLICSILITYRVRVLNRIAQFYIELSRNTPLLIQLFFLYYGLPKLGIKIDGFTCGVIGLTFLGGSYMAEAFRAGLQSVVKGQIDSAKSIGLQPIQIFRYVIFPQALAISIPAIGANCLFLIKESSVVSAIAVVELLFVTKDLIGMDYKTTEALFLLIMAYLIILLPVSILTSYLEHRSRKVSHGT
>NZ_CP042994.1|WP_025466845.1|2328518_2328923_+|hypothetical-protein
MMQLPQTQSSLQYIHISVPEILLSNIQIKNIWQDYNQEWSYRLDPPHASHPFQRDLHIIKSKNIEKEDIKEPFDNLVAKNKPELKSIVEAETVIKEILDLSDYIPIENWLEDTGNRSIIESMIDKNKVKLLDII
>NZ_CP042994.1|WP_004709384.1|2329064_2329943_+|glucose-1-dehydrogenase
MENTTNEYPSAVPAQVQPHQPGDQEKMHPEPEIIKASHKGSEKLKGKVAVISGGDSGIGRSVAVLFAREGADIAVLYLEEDQDAEITKQLVEKEGQHCLLLKGDISDADLAKQNIDKVLQHFGKINILVNNAGVQYQQKEIESISNEQLEKTFKTNIFAMFYLTKEAIPYMEEGDSIINTTSITSYQGHDELIDYASTKGAITSFTRSLSNNLMKQKKGIRVNGVAPGPIWTPLIPSSFDAETVEKFGKDTPMGRMGQPSEVAPAYLFLASDDASYITGQVIHVNGGQIVNG
>NZ_CP042994.1|WP_081404483.1|2329999_2332144_-|catalase-HPII
MDMNDKTKLTNKTSEMAGADAANKANTTQKTEQLDTVRDDATNEALTTNQGVKIADNQNSLRAGIRGSTLLEDFILREKITHFDHERIPERIVHARGVGAHGYFQAYEGNERLTKAGFLTDPTIQTPIFVRFSTVQGPRGSADTVRDIRGFAIKFYTQEGNFDLVGNNAPVFFVQDGIKFPDFVHAVKPEPDTEIPTGATAHDTFWDFVSLVPESAHAVIWAMSDRAIPRNLRSIQGFGVHTFRLINAEGKSHFVKFHWTPKQGLSALVWDEAQKLAGKDPDFHRRDLYEAIEQGFYPEWELGVQIVEEEDEMNFDFDLLDPTKIIPEELVPVTPIGRFVLNRNVDNFFAETEQVAFCPGHVVPGIDFTDDPLLQARLFSYTDTQLSRLGGPNFHQIPINKPVCPFHNNQRDGIHQHTIHKGQASYQPNSIDGNWPVETPPAASNGGFESYPEKISGHKLRQRSETFSDYFSQPRLYYKSLAPHEQKHVVDAYTFELSKVQRKHIRERQVQQILANIDLDLARQVGANLGIEVPDLTLDYKKTAIEKSAKLSFLAFPPEDIQGRKVAVLIHNLVKLDTLEAIKNWAIKEGVVVHLLAPSLAPVKDHKDNIIVADGMQMAEPSIAYDAVIVPDGDNLNAVMQDGVARHYVLEAYKHLKPIAFLGNKSDLLEPLGLVADEGTLVEDEFQHIAEKFKNLIKAHRVWSREQIAAHVPA
>NZ_CP042994.1|WP_032011844.1|2332196_2333606_-|iron-containing-redox-enzyme-family-protein
MPVVVKKRLLDLLQDNQQNYYELFVFFLDPDVSSFEKEKKARDFLIKEIDKLEMTEIDFPSSIDSIKEWCENDNKKNCQEFQAYLNRRQDGHGREYFQNVAQAFEFLIKVSPTKKVDGAWLYSSVHYWNDPVFHELIITYLEELGLGEPKANHVCIYDDLLRSLGLDSFDLLLEDDYYHQAVVQLALGYAPPEFIPEIVGFNLGYEQLPLHLLISNYELAELGIDSKYFNLHITIDNIDNGHAYKAIKVIEDIYNKYRDKELFFIKLKQGFALNNRGESSSNIIKNLSLEDFVHKILKRKALVGQLIHNETRQFGCKTINQWLSNPDDIAGLINHLTEQKWIKFNTDPEQSVFWRMINEENGKMFGVFNPVERQIIHDWIAGSDHSSNFLAYSRELKNSQRIQDYLFSYISDGELDALQERVLQSSDLAIKICKLTPFLAPDSHHKSIGLWSTRKYVELLFPYLGTFKN
>NZ_CP042994.1|WP_032011843.1|2333921_2334401_+|CinA-family-protein
MFNSCCKLLAKEKIKIAFFESASAGYLAYRFSLSPYSGDILIGSLVSYDLRVKENTLHISEELIEKYTAESMQVTVEMINKGKELLHADLYVACTGLLKKGGSETQEKPVGTFFYSIYYQNNFYNFRRVLKGPAFLKLRKLTYYITQDIKFIILDKKTP
>NZ_CP042994.1|WP_000108365.1|2334676_2334898_+|hypothetical-protein
MSTTNNQANQRNNQQQQQQQNDNRNQQQHGNQQQNDQQQQNNQQQQQNDNRGQQQGSNQKDSGQQNSNNNQQR
>NZ_CP042994.1|WP_002048358.1|2335003_2335321_+|hypothetical-protein
MTDQNTDHAQLVAGDHNYSDSRWRESYLTRPYYQEAQLTTPDLDYDRDFSAAYELGHRARSESKEGTQFEDMEGSLKQKWEELKAESRLKWEHAKQAIKDAWDDM
>NZ_CP042994.1|WP_032011842.1|2335390_2335612_-|hypothetical-protein
MFVYFTDGTCINDSEIYGVKAKHEQNKYVVEVTIKPTHVLTTTVSVQFKKEVFDDPNLANQYLNHNFDMPPYF
>NZ_CP042994.1|WP_001136759.1|2335699_2336128_-|hypothetical-protein
MPQYLKIAEKIYQNVKEKKGFTDDPMEDLNNLMIELRQEIKGTKLKLLYNYIDFAEILIKPLQESKIKLDLSLIPKSKNTQEFVLWLAGFIERITTGGQEKLPPIRAKITLPAYAYEETYPSQKKPVNNGEEIIEYFKKNQS
>NZ_CP042994.1|WP_002048336.1|2336398_2336542_-|hypothetical-protein
MVRIFCAVSMVLAIAMGMSACQDRNSKNDGMHGASDPATSHDMNKNS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP042994_2	2.3\|502305\|36\|NZ_CP042994\|CRT	502305-502340	36	KU594606	Cyanophage S-RIM32 isolate RW_108_0702, complete genome	101492-101527	10	0.722
NZ_CP042994_2	2.4\|502365\|36\|NZ_CP042994\|CRT	502365-502400	36	KU594606	Cyanophage S-RIM32 isolate RW_108_0702, complete genome	101492-101527	10	0.722

1. spacer 2.3|502305|36|NZ_CP042994|CRT matches to KU594606 (Cyanophage S-RIM32 isolate RW_108_0702, complete genome) position: , mismatch: 10, identity: 0.722

gccaagagggttaccaccagtaacaccaccagttaa	CRISPR spacer
aagttgaatcttaccaccagtaacactaccagtgaa	Protospacer
.    **.  ****************.****** **

2. spacer 2.4|502365|36|NZ_CP042994|CRT matches to KU594606 (Cyanophage S-RIM32 isolate RW_108_0702, complete genome) position: , mismatch: 10, identity: 0.722

gccaagagggttaccaccagtaacaccaccagttaa	CRISPR spacer
aagttgaatcttaccaccagtaacactaccagtgaa	Protospacer
.    **.  ****************.****** **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1178789 : 1188696

Acinetobacter_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_085940844.1\|1178789_1179955_-\|transposase	IS3-like element ISAba22 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.6e-164	99.6
WP_001187844.1\|1180438_1180987_-	GTP cyclohydrolase I FolE	A0A0P0HSD2	Acinetobacter_phage	1.7e-97	100.0
WP_106479699.1\|1181248_1182748_+	xanthine dehydrogenase small subunit	A0A0P0IVM8	Acinetobacter_phage	3.3e-271	93.0
WP_032010260.1\|1182749_1185125_+	xanthine dehydrogenase molybdopterin binding subunit	A0A0P0I429	Acinetobacter_phage	0.0e+00	97.0
WP_106479701.1\|1185131_1186115_+	xanthine dehydrogenase accessory protein XdhC	A0A0P0IKN7	Acinetobacter_phage	4.7e-178	93.6
WP_032010258.1\|1186125_1186821_-	Smr/MutS family protein	A0A0P0IDT4	Acinetobacter_phage	6.0e-119	97.4
WP_032010257.1\|1186830_1187637_-	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	4.3e-145	98.5
WP_009498528.1\|1187646_1188696_-	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	3.1e-188	98.6

DBSCAN-SWA_2

1536149 : 1605306

Escherichia_phage(20.0%)

protease,coat,holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148356656.1\|1536149_1536566_+\|coat	spore coat protein U domain-containing protein	NA	NA	NA	NA
WP_032010777.1\|1538058_1538763_+	molecular chaperone	NA	NA	NA	NA
WP_106479789.1\|1538772_1541232_+	fimbrial biogenesis outer membrane usher protein	NA	NA	NA	NA
WP_032011809.1\|1541222_1542242_+\|coat	spore coat protein U domain-containing protein	NA	NA	NA	NA
WP_032011808.1\|1542403_1543177_+	DUF4882 family protein	NA	NA	NA	NA
WP_106479788.1\|1543426_1544113_+	glutathione S-transferase family protein	NA	NA	NA	NA
WP_148356657.1\|1544189_1545409_-\|transposase	IS3 family transposase	A0A0N7C1X7	Escherichia_phage	1.2e-77	53.2
WP_148356658.1\|1545477_1546194_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_032011805.1\|1546203_1546887_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_032011804.1\|1546965_1547523_+	chorismate mutase	NA	NA	NA	NA
WP_004700991.1\|1547551_1548049_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_032011802.1\|1548691_1549030_+	hypothetical protein	NA	NA	NA	NA
WP_148356659.1\|1549362_1553421_+	hypothetical protein	NA	NA	NA	NA
WP_032011800.1\|1554043_1554598_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_032011799.1\|1554662_1556897_-	TonB-dependent receptor	NA	NA	NA	NA
WP_032011798.1\|1557049_1557823_-	aldolase	NA	NA	NA	NA
WP_106479819.1\|1557815_1561343_-	siderophore biosynthesis protein	NA	NA	NA	NA
WP_106479818.1\|1561339_1562545_-	MFS transporter	NA	NA	NA	NA
WP_079377527.1\|1562548_1564189_-	siderophore biosynthesis protein	NA	NA	NA	NA
WP_002048660.1\|1564260_1565274_-	2,3-diaminopropionate biosynthesis protein SbnB	NA	NA	NA	NA
WP_032011794.1\|1565295_1566300_-	2,3-diaminopropionate biosynthesis protein SbnA	A0A1W6JHY1	Lactococcus_phage	5.0e-42	35.7
WP_032011793.1\|1566906_1568142_+	mechanosensitive ion channel	NA	NA	NA	NA
WP_032011792.1\|1568452_1568704_+	hypothetical protein	NA	NA	NA	NA
WP_032011790.1\|1569117_1569588_+	hypothetical protein	A0A0P0HSF5	Acinetobacter_phage	2.4e-31	45.4
WP_032011788.1\|1569749_1570124_+	hypothetical protein	NA	NA	NA	NA
WP_148356657.1\|1570601_1571820_+\|transposase	IS3 family transposase	A0A0N7C1X7	Escherichia_phage	1.2e-77	53.2
WP_002048661.1\|1573946_1574078_+	hypothetical protein	NA	NA	NA	NA
WP_032011786.1\|1574122_1574824_-	hypothetical protein	NA	NA	NA	NA
WP_148356758.1\|1576556_1576928_+	DNA breaking-rejoining protein	NA	NA	NA	NA
WP_032011785.1\|1576988_1578572_-	ABC-F family ATP-binding cassette domain-containing protein	A0A1V0SKJ1	Klosneuvirus	1.4e-30	26.1
WP_002053669.1\|1578831_1579275_-	universal stress protein	NA	NA	NA	NA
WP_000774578.1\|1579563_1579791_+	hypothetical protein	NA	NA	NA	NA
WP_002053613.1\|1580399_1580843_+	RDD family protein	NA	NA	NA	NA
WP_032011784.1\|1581403_1584160_+	magnesium-translocating P-type ATPase	A0A1J0FA34	Only_Syngen_Nebraska_virus	8.4e-39	23.4
WP_002053619.1\|1584175_1584895_+	MgtC/SapB family protein	G3MA03	Bacillus_virus	1.7e-12	38.5
WP_032011783.1\|1584968_1586141_-	benzoate/H(+) symporter BenE family transporter	NA	NA	NA	NA
WP_000344224.1\|1586328_1586802_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_004708223.1\|1586838_1587489_-	leucine efflux protein LeuE	NA	NA	NA	NA
WP_002053629.1\|1587562_1588552_-	transaldolase	NA	NA	NA	NA
WP_148356662.1\|1588682_1589576_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_004701059.1\|1589666_1590101_+	chlorhexidine efflux PACE transporter AceI	NA	NA	NA	NA
WP_002053671.1\|1590168_1591737_-	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_032011778.1\|1591972_1593364_+	3-oxoacyl-ACP reductase	NA	NA	NA	NA
WP_017393394.1\|1593438_1594293_+	hypothetical protein	NA	NA	NA	NA
WP_032011777.1\|1594364_1595624_+	serine hydrolase	A0A2K9L1U3	Tupanvirus	3.0e-12	23.7
WP_004708240.1\|1595676_1596255_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_032011776.1\|1596381_1597860_+	multidrug efflux MFS transporter AmvA	A0A0M3UL24	Mycobacterium_phage	1.8e-27	26.4
WP_032011775.1\|1598116_1599898_+	metalloendopeptidase CpaA	NA	NA	NA	NA
WP_000739695.1\|1599920_1600535_+\|protease	metalloprotease secretion chaperone CpaB	NA	NA	NA	NA
WP_148356663.1\|1600658_1602752_+	DNA polymerase III subunit gamma/tau	A0A1L2BWV7	Bacteriophage	3.0e-41	31.2
WP_155758180.1\|1602898_1603051_+	hypothetical protein	NA	NA	NA	NA
WP_032011773.1\|1603077_1605306_+\|holin	phospholipase C, phosphocholine-specific	NA	NA	NA	NA

DBSCAN-SWA_3

1609503 : 1664528

Paenibacillus_phage(55.56%)

coat,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_099143725.1\|1609503_1610255_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.6e-24	45.8
WP_032011767.1\|1610507_1611011_+	low molecular weight phosphotyrosine protein phosphatase	NA	NA	NA	NA
WP_032011766.1\|1611030_1612065_+	UDP-N-acetylmuramate dehydrogenase	NA	NA	NA	NA
WP_002052109.1\|1612069_1613200_+	YdcF family protein	NA	NA	NA	NA
WP_002052112.1\|1613199_1614228_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002122556.1\|1614845_1615592_+\|transposase	IS5-like element ISAba31 family transposase	A0A0N9SHJ4	Paenibacillus_phage	4.3e-14	35.9
WP_004886670.1\|1615708_1616764_-	linear amide C-N hydrolase	NA	NA	NA	NA
WP_171073649.1\|1616974_1618393_-	FMN-binding glutamate synthase family protein	NA	NA	NA	NA
WP_002052103.1\|1619175_1619607_+	hypothetical protein	NA	NA	NA	NA
WP_099143725.1\|1619910_1620661_+\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.6e-24	45.8
WP_079377547.1\|1620994_1621489_+\|coat	spore coat protein U domain-containing protein	NA	NA	NA	NA
WP_004708276.1\|1621580_1622288_+	molecular chaperone	NA	NA	NA	NA
WP_032012105.1\|1622298_1624737_+	fimbrial biogenesis outer membrane usher protein	NA	NA	NA	NA
WP_099143725.1\|1624855_1625606_+\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.6e-24	45.8
WP_081404506.1\|1626873_1628022_+	MFS transporter	NA	NA	NA	NA
WP_002049607.1\|1628169_1628673_+	hypothetical protein	NA	NA	NA	NA
WP_002049609.1\|1628727_1630098_-	acetyl-CoA carboxylase biotin carboxylase subunit	NA	NA	NA	NA
WP_000354611.1\|1630114_1630534_-	acetyl-CoA carboxylase biotin carboxyl carrier protein	NA	NA	NA	NA
WP_106479784.1\|1630551_1631007_-	type II 3-dehydroquinate dehydratase	NA	NA	NA	NA
WP_032012101.1\|1631242_1632571_-	Y-family DNA polymerase	A0A2H4JBL5	uncultured_Caudovirales_phage	1.3e-101	44.1
WP_032012100.1\|1632905_1633916_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001125253.1\|1633916_1634507_-	ANTAR domain-containing protein	NA	NA	NA	NA
WP_002049585.1\|1634891_1635233_+	hypothetical protein	NA	NA	NA	NA
WP_171073650.1\|1635256_1637791_+	nitrite reductase large subunit	NA	NA	NA	NA
WP_032012097.1\|1637803_1639426_+	nitrite reductase small subunit NirD	NA	NA	NA	NA
WP_106479782.1\|1639444_1642225_+	nitrate reductase	NA	NA	NA	NA
WP_032012095.1\|1642221_1642851_+	NTP transferase domain-containing protein	NA	NA	NA	NA
WP_032012094.1\|1643001_1645275_+	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_106479781.1\|1645501_1646542_+	GTP 3',8-cyclase MoaA	NA	NA	NA	NA
WP_001187656.1\|1646542_1646797_+	MoaD/ThiS family protein	NA	NA	NA	NA
WP_000657202.1\|1646800_1647289_+	molybdenum cofactor biosynthesis protein MoaE	NA	NA	NA	NA
WP_032012091.1\|1647312_1648236_+	bifunctional molybdenum cofactor biosynthesis protein MoaC/MoaB	NA	NA	NA	NA
WP_032012090.1\|1648235_1649471_+	molybdopterin molybdotransferase MoeA	NA	NA	NA	NA
WP_002049640.1\|1649680_1650163_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_032012089.1\|1650159_1651563_-	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_081404505.1\|1651696_1652548_+	DMT family transporter	NA	NA	NA	NA
WP_001047539.1\|1652552_1652864_-	TusE/DsrC/DsvC family sulfur relay protein	A0A2H4J8B6	uncultured_Caudovirales_phage	2.0e-18	43.1
WP_016804880.1\|1652883_1653168_-	hypothetical protein	NA	NA	NA	NA
WP_148356664.1\|1653185_1653536_-	hypothetical protein	NA	NA	NA	NA
WP_000105718.1\|1653580_1653949_-	sulfurtransferase complex subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	6.8e-13	37.0
WP_032012087.1\|1654014_1655022_+	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	9.5e-49	32.2
WP_004708382.1\|1655136_1656531_+	class II fumarate hydratase	NA	NA	NA	NA
WP_004708384.1\|1656649_1656946_-	hypothetical protein	NA	NA	NA	NA
WP_032012086.1\|1657128_1657590_-	hypothetical protein	NA	NA	NA	NA
WP_004708388.1\|1657901_1658393_+	hypothetical protein	NA	NA	NA	NA
WP_106479780.1\|1658804_1660049_+	D-amino acid dehydrogenase	NA	NA	NA	NA
WP_079377059.1\|1660095_1660722_-	hypothetical protein	NA	NA	NA	NA
WP_032011520.1\|1660843_1661326_+	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
WP_032011521.1\|1661322_1661847_-	hypothetical protein	NA	NA	NA	NA
WP_002049620.1\|1662039_1662960_-	ornithine carbamoyltransferase	NA	NA	NA	NA
WP_032011523.1\|1663072_1663726_-	multidrug efflux RND transporter permease subunit AdeJ	NA	NA	NA	NA
WP_099143725.1\|1663776_1664528_-\|transposase	IS5 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.6e-24	45.8

DBSCAN-SWA_4

2611842 : 2637043

Acinetobacter_phage(62.96%)

capsid,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002126831.1\|2611842_2612823_-	DUF2184 domain-containing protein	H9C0E5	Vibrio_phage	1.1e-06	22.2
WP_049590668.1\|2612826_2613297_-	hypothetical protein	M4T3R5	Psychrobacter_phage	1.4e-18	43.1
WP_106479470.1\|2613315_2614515_-	DUF2213 domain-containing protein	H9C194	Pectobacterium_phage	1.8e-25	33.9
WP_049590670.1\|2614575_2615190_-	hypothetical protein	NA	NA	NA	NA
WP_106479469.1\|2615247_2616057_-\|capsid	minor capsid protein	M4T3R2	Psychrobacter_phage	1.3e-51	41.8
WP_106479468.1\|2616001_2617336_-	DUF1073 domain-containing protein	M4SN90	Psychrobacter_phage	6.4e-85	38.9
WP_106479467.1\|2617344_2618871_-\|terminase	phage terminase large subunit	A0A291LBL3	Klebsiella_phage	1.2e-90	40.6
WP_000729394.1\|2618848_2619325_-	DUF2280 domain-containing protein	A0A0P0HSK4	Acinetobacter_phage	4.5e-33	53.6
WP_106479465.1\|2619384_2620026_-	hypothetical protein	J7I4N9	Acinetobacter_phage	7.4e-124	98.1
WP_000378513.1\|2619994_2620462_-	hypothetical protein	A0A0P0IRI6	Acinetobacter_phage	7.4e-65	78.1
WP_000195746.1\|2620522_2620978_-	hypothetical protein	A0A0P0HSF5	Acinetobacter_phage	5.2e-79	94.7
WP_000152665.1\|2621638_2621875_-	hypothetical protein	NA	NA	NA	NA
WP_001005051.1\|2622083_2622428_-	hypothetical protein	NA	NA	NA	NA
WP_106479464.1\|2622694_2622913_-	hypothetical protein	NA	NA	NA	NA
WP_000861102.1\|2623398_2623653_-	hypothetical protein	NA	NA	NA	NA
WP_106479463.1\|2623624_2624101_-	hypothetical protein	A0A2H4J548	uncultured_Caudovirales_phage	3.4e-25	39.6
WP_106479462.1\|2624097_2624499_-	DUF559 domain-containing protein	A0A0P0I8E8	Acinetobacter_phage	3.5e-63	92.4
WP_148356687.1\|2624498_2624954_-	hypothetical protein	NA	NA	NA	NA
WP_106479461.1\|2624950_2625751_-	hypothetical protein	A0A0P0IDV1	Acinetobacter_phage	2.9e-149	98.9
WP_106479460.1\|2625753_2626635_-	replication protein	A0A0P0IKQ2	Acinetobacter_phage	1.1e-141	99.7
WP_002037796.1\|2626627_2626852_-	hypothetical protein	A0A0P0I444	Acinetobacter_phage	6.5e-35	98.6
WP_001095598.1\|2626923_2627199_-	hypothetical protein	A0A0P0IVP2	Acinetobacter_phage	8.9e-42	100.0
WP_000049328.1\|2627254_2627575_-	hypothetical protein	A0A0P0HSE9	Acinetobacter_phage	1.3e-49	99.1
WP_000996063.1\|2627585_2627837_-	hypothetical protein	A0A0N7IRE1	Acinetobacter_phage	8.9e-41	100.0
WP_001093655.1\|2627945_2628710_+	LexA family transcriptional regulator	A0A0P0J076	Acinetobacter_phage	1.1e-137	95.6
WP_000203858.1\|2628742_2629681_+	hypothetical protein	NA	NA	NA	NA
WP_106479459.1\|2629685_2630594_+	hypothetical protein	NA	NA	NA	NA
WP_106479458.1\|2630794_2631238_+	hypothetical protein	A0A0N7IRF7	Acinetobacter_phage	1.9e-73	96.6
WP_000656410.1\|2631237_2631528_+	hypothetical protein	A0A0P0IDU2	Acinetobacter_phage	1.6e-49	99.0
WP_106479457.1\|2631520_2631844_+	hypothetical protein	A0A0P0IRC4	Acinetobacter_phage	1.2e-53	94.4
WP_001207472.1\|2631855_2632977_+	ATP-binding protein	A0A0N7IRE0	Acinetobacter_phage	2.6e-209	98.4
WP_064479063.1\|2633005_2633302_+	hypothetical protein	NA	NA	NA	NA
WP_148356688.1\|2633476_2634199_+	hypothetical protein	A0A0P0HSE1	Acinetobacter_phage	7.5e-56	87.4
WP_000362184.1\|2634200_2634416_+	hypothetical protein	A0A0R6PG25	Moraxella_phage	3.7e-11	55.9
WP_001185176.1\|2634625_2635906_+	aspartate kinase	NA	NA	NA	NA
WP_000906487.1\|2636152_2636407_+	carbon storage regulator CsrA	A0A2I7RT00	Vibrio_phage	8.8e-12	66.7
WP_000495832.1\|2636476_2637043_-	ribonuclease HII	E3T5H8	Cafeteria_roenbergensis_virus	3.1e-25	42.4

DBSCAN-SWA_5

3788556 : 3799364

Enterobacteria_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148356714.1\|3788556_3789414_-	SDR family oxidoreductase	A0A1V0SAG7	Catovirus	7.3e-34	37.1
WP_148356764.1\|3789414_3790452_-	polysaccharide biosynthesis protein	K7Y9E1	Megavirus	1.9e-44	38.6
WP_148356715.1\|3790602_3791154_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	7.5e-48	54.7
WP_148356716.1\|3791223_3792114_-	glucose-1-phosphate thymidylyltransferase RfbA	A0A291LA53	Escherichia_phage	3.2e-109	65.9
WP_148356717.1\|3792113_3793019_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	6.8e-30	32.6
WP_148356718.1\|3793035_3794112_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.3e-99	53.4
WP_148356719.1\|3794134_3795412_-	Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB	A0A218MKK1	uncultured_virus	3.8e-10	24.1
WP_171489996.1\|3795574_3796717_+	polysaccharide biosynthesis/export family protein	NA	NA	NA	NA
WP_148356721.1\|3796718_3797147_+	low molecular weight phosphotyrosine protein phosphatase	NA	NA	NA	NA
WP_148356722.1\|3797168_3799364_+	polysaccharide biosynthesis tyrosine autokinase	A0A1X9I5D6	Streptococcus_phage	4.5e-19	34.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP042995

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP042994

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection