CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP043006	Chitinophaga sp. XS-30 chromosome, complete genome	16 crisprs	csa3,WYL,DEDDh,cas3	0	7	1	0

1. NZ_CP043006

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP043006_1

• CRISPR_ID: NZ_CP043006_1
• CRISPR_location: 907539-907625
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_1

Consensus_repeat	Method
AACGACGGAAGGAGCAGGCGGATCTTT	CRISPRCasFinder

spacers of NZ_CP043006_1

>1.1|907566|33|NZ_CP043006|CRISPRCasFinder
TGTGATCACCGGGGCAGGTTTCGCTTTCACGGA

CRISPR arrays and Neighbor proteins around NZ_CP043006_1

CRISPR arrays

The CRISPR arrays of NZ_CP043006_1

>merge|NZ_CP043006|1|907539-907625|CRISPRCasFinder
AACGACGGAAGGAGCAGGCGGATCTTTTGTGATCACCGGGGCAGGTTTCGCTTTCACGGAAACGACGGAAGGAGCAGGCGCATCTTT

>NZ_CP043006|1|1|907539-907625|CRISPRCasFinder
AACGACGGAAGGAGCAGGCGGATCTTT	TGTGATCACCGGGGCAGGTTTCGCTTTCACGGA
AACGACGGAAGGAGCAGGCGCATCTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_168208653.1|907852_909154_-|histidine-kinase	unknown	unknown	gnl|CDD|225814
NZ_CP043006.1|WP_168208655.1|916544_917030_+|gliding-motility-lipoprotein-GldH	unknown	unknown	gnl|CDD|379474
NZ_CP043006.1|WP_148382948.1|902451_903672_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_168208654.1|914948_915590_+|pseudouridine-synthase	unknown	unknown	gnl|CDD|211334
NZ_CP043006.1|WP_148382944.1|899145_899586_+|SnoaL-like-domain-containing-protein	unknown	unknown	gnl|CDD|226158
NZ_CP043006.1|WP_148382950.1|904286_905114_+|formyltetrahydrofolate-deformylase	unknown	unknown	gnl|CDD|235676
NZ_CP043006.1|WP_148382952.1|906042_906630_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148382959.1|912142_912847_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148382946.1|901065_901452_-|DUF5367-family-protein	unknown	unknown	gnl|CDD|340045
NZ_CP043006.1|WP_148382956.1|909206_910235_+|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl|CDD|234780
NZ_CP043006.1|WP_148382960.1|912857_913799_-|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	unknown	unknown	gnl|CDD|234858
NZ_CP043006.1|WP_148382949.1|903754_904252_+|DUF1648-domain-containing-protein	unknown	unknown	gnl|CDD|377929
NZ_CP043006.1|WP_148382947.1|901536_902400_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225117
NZ_CP043006.1|WP_148382945.1|899959_900721_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148382961.1|914223_914928_-|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl|CDD|223736
NZ_CP043006.1|WP_148382957.1|910250_911093_+|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|236211
NZ_CP043006.1|WP_148382958.1|911144_912140_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187539
NZ_CP043006.1|WP_148382963.1|915645_916521_+|YicC-family-protein	unknown	unknown	gnl|CDD|236993
NZ_CP043006.1|WP_148382951.1|905164_905842_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148382953.1|906678_907419_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|180411

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_168208653.1|907852_909154_-|histidine-kinase	gnl|CDD|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	7.32468e-26
NZ_CP043006.1|WP_168208654.1|914948_915590_+|pseudouridine-synthase	gnl|CDD|211334	cd02566, PseudoU_synth_RluE, Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.	9.61932e-67
NZ_CP043006.1|WP_148382953.1|906678_907419_+|SDR-family-oxidoreductase	gnl|CDD|180411	PRK06123, PRK06123, SDR family oxidoreductase.	1.52319e-130
NZ_CP043006.1|WP_148382950.1|904286_905114_+|formyltetrahydrofolate-deformylase	gnl|CDD|235676	PRK06027, purU, formyltetrahydrofolate deformylase; Reviewed.	2.36806e-130
NZ_CP043006.1|WP_148382944.1|899145_899586_+|SnoaL-like-domain-containing-protein	gnl|CDD|226158	COG3631, COG3631, Ketosteroid isomerase-related protein [General function prediction only].	6.17412e-10
NZ_CP043006.1|WP_148382946.1|901065_901452_-|DUF5367-family-protein	gnl|CDD|340045	pfam17329, DUF5367, Family of unknown function (DUF5367). This bacterial family of proteins of unknown function is predicted to contain 3 or 4 trans-membrane regions.	8.82553e-09
NZ_CP043006.1|WP_148382956.1|909206_910235_+|phenylalanine--tRNA-ligase-subunit-alpha	gnl|CDD|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP043006.1|WP_148382960.1|912857_913799_-|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase	gnl|CDD|234858	PRK00892, lpxD, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional.	1.48879e-93
NZ_CP043006.1|WP_148382949.1|903754_904252_+|DUF1648-domain-containing-protein	gnl|CDD|377929	pfam07853, DUF1648, Protein of unknown function (DUF1648). Members of this family are hypothetical proteins expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	1.09123e-10
NZ_CP043006.1|WP_148382947.1|901536_902400_-|helix-turn-helix-domain-containing-protein	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.94361e-27
NZ_CP043006.1|WP_148382963.1|915645_916521_+|YicC-family-protein	gnl|CDD|236993	PRK11820, PRK11820, YicC family protein.	5.9126e-97
NZ_CP043006.1|WP_148382961.1|914223_914928_-|cyclic-nucleotide-binding-domain-containing-protein	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	2.59944e-45
NZ_CP043006.1|WP_148382957.1|910250_911093_+|3-hydroxybutyryl-CoA-dehydrogenase	gnl|CDD|236211	PRK08268, PRK08268, 3-hydroxy-acyl-CoA dehydrogenase; Validated.	9.09262e-125
NZ_CP043006.1|WP_168208655.1|916544_917030_+|gliding-motility-lipoprotein-GldH	gnl|CDD|379474	pfam14109, GldH_lipo, GldH lipoprotein. Members of this protein family are predicted lipoproteins, exclusive to the Bacteroidetes phylum. Proteins in this family are typically between 155 and 167 amino acids in length. Members include GldH, a protein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Not all Bacteroidetes with members of this protein family may have gliding motility.	6.95039e-45
NZ_CP043006.1|WP_148382958.1|911144_912140_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187539	cd05228, AR_FR_like_1_SDR_e, uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs. This subgroup contains proteins of unknown function related to aldehyde reductase and flavonoid reductase of the extended SDR-type. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. The related flavonoid reductases act in the NADP-dependent reduction of flavonoids, ketone-containing plant secondary metabolites. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.46733e-91

Protein sequences

>NZ_CP043006.1|WP_148382953.1|906678_907419_+|SDR-family-oxidoreductase
MKTILITGASRGIGAATAILAAERGYRVCINYHHNQTAAEQVAGTIRAKGGTAFLLQGDVSSEADVCRMFREVDSIGPLHALVNNVGILEKQTRVENIDAERLSRVLRSNVISCFICAREAIRRMSVKHGGAGGAIVNVSSIAARTGSPGEYVDYAASKGAMDAFTTGLSKEVADEGIRVNGVRPGFIYTDIHASGGEPGRVDRIRDTIPMKRGGQPEEVAEAILWLLSDGSSFSTGTFIDITGGR
>NZ_CP043006.1|WP_148382952.1|906042_906630_+|hypothetical-protein
MIICTMFACNSGTSSCPAISLEGKDAIAAIRAKDSLIPETFIAVPDKHLASSTREVEAVLDQLAEAGLLQYRLTDSLPGKRSLGGTEETPFYQYAVDWSSALEEQAVQQAERDSVTAITFFGKQLHGEVRFAARKFLAGEIRIEGSMPLFYKEDCHELAYKYTYTIDSTNALARIAGMNPYIKSTRAVTTTVSYN
>NZ_CP043006.1|WP_148382951.1|905164_905842_+|hypothetical-protein
MSSLLPEYMEKIKNEISSKIDEVINNRTIKSLSRDVFKRGLIDNKKKMGFHKKYLEITGKKEAIEIKKKFFSDFRHLYGLQYMDSGFIHKLERKKNEIIKLIGSCPFQAYEKYFHQAKITEKECVKRKNLMSFFTKLSHTIHPKRCSAMDNQIKRYFGLRKEGFFFSYCLINESYLTWIKNNRPKLAMIKDIVRNLDAENALKISAVSDLKILDMIFWFKANSQK
>NZ_CP043006.1|WP_148382950.1|904286_905114_+|formyltetrahydrofolate-deformylase
MIILIQSIDRVGLVAAISGITAKHGLNIISLREHVDKVENRFFMRIETENDTAAPVLETEIKSVLPQDALVTIDPRPEKKIIVMVTKEYHCLADILVRNYFGTLGASVQCVIGNHNVLENICTRFDVPFHLVSHEEHDRQAFEEKIIRIIDGHQPDYIVLAKFMRILSPGFVKQYPTRIINIHHSFLPAFAGAHPYRQAFERGVKLIGATSHFVTNELDEGPIIAQQVIPVNHSFTAAGMMKAGQEIEVSVLARALRLVFTDRVFVYENKTVVFE
>NZ_CP043006.1|WP_148382949.1|903754_904252_+|DUF1648-domain-containing-protein
MNTKPKLHPTPNTLDQLLESAGWIALTSLWAIAIYHYSNLPDTIPTHYNFTGQPDRYGGKAALLVLPVIGTLLFAGMTILGKRPHLFNYPRAITATNALQQYTLATRLLRFLKLGIILVFLLVVWDTIAVATGQSKGLGWWSMIALPFMIVLPATWYIIKAMKAR
>NZ_CP043006.1|WP_148382948.1|902451_903672_-|hypothetical-protein
MIEKTLTLMLCAAACLPVKSQTLQEVTTNGNQTNKSIIIDNGSSNGRMTLLSEQSITKIFGNATGSTTTFQPLALLGSRTLIGPGNQAIVDDGSNTLQVNGTFRAGVGNNYFRYNGSSDLWLRFEDRGTGGRAMVHDGGNVLGLNYGGDFTGGTKIGTKAYFSENGNSYFMAGNVGIGTNTPLSKLQLGSYGTNNASHITIPGVYNFEVMKIGQTGNGNTVIEMVNHVSMTHSYGIKMGTNIDQHGSGFYIRAAPIASSYENLTYDVPAFYINTSSQVGIGTTNTAGYKLAVAGNMIAEKVKVKLKTGWPDFVFENGYKLPDLHEVEEFIKTNKHLPEVPTAAEISADGLDLGNNQALLLKKIEELTLYLIDQHKLLKSQQEQIKLQQETILMLESRMDTLLSAIR
>NZ_CP043006.1|WP_148382947.1|901536_902400_-|helix-turn-helix-domain-containing-protein
MTRDILAINDFVVLIEASASEATVVERCGFDRQIVCFSFYGSGNVDLTVNYEGGPRTYTNTKGLAISFAADKGVEFVHTISASQPLNCICVYATIPNLLNRPEYEVDTFVTHVPELLEPKESYVEGPAFYMSPDMLSAVDKIFNTRYQGATRLMFIRSQVMELLSHFFAIAAGQCHIKPSGAADKLFQVKEILDRNMDAPPSLQELSRMIGLNSSRLKKDFREMFGMPVFKYLQQERLGKAHSLLTTTDKSIQEVAWFVGYDSLSSFSSAFLKKFGIRPSEVRKKSS
>NZ_CP043006.1|WP_148382946.1|901065_901452_-|DUF5367-family-protein
MDIIRAVTSGVMVWIFVFSTFFVLSLIPGINASETLQSVIVCIMLVLYSFLGARYYYRKGAQTNGLVAGLLMAGVILLLDAVITVPLVIYPAGGNHFTFFTSLILWVLVLEHLLVTFLYWKLKVPALR
>NZ_CP043006.1|WP_148382945.1|899959_900721_+|hypothetical-protein
MGRQTSLLTFTGRVGNLIGYNRNGKHFMRCMPETIRQTSATRQAAQRFGAASRKGRLIRSAFAGEVDIRPDGSRVNRLNKAIIKGGYNNPEAIAGFQFNRYTGIDKFFRVAPVLSADGILHIPAQTLKEIKGFTALEVKVVAARISFAERKVVHTETAVIVLDTREPFAGAALSVDAPGKGTLVVTLQVRALKDGHPSGNRKYAAADIIAVQEPQTKQVFHKPECPKEIAIRQRLDALFDPSREQSIHIVQRE
>NZ_CP043006.1|WP_148382944.1|899145_899586_+|SnoaL-like-domain-containing-protein
MAEQKSNQEFETKNVGQEIKEALVKADVSGDWSGFLDMMDDDVTFRATIPEGTPISGVFRGKIKVVEYFDAVLPSVASFSQNKPMEFIVDQNKVIVLGDDTYTIVKNGKSQRSPYAMVIDFKDDKISSILIIQDLSGIYLAYAPNP
>NZ_CP043006.1|WP_168208653.1|907852_909154_-|histidine-kinase
MRDAQHCHILLLMPVVYYIVLITALLLSAWLYRQMMLYRRKYREEATFNYFTTSLFGKNTVDDILWDVAKNCISQLRLEDCVIYLLDEERQVLVQKAAYGPKNPVRFEIRDPIEIPLGRGIVGAVALHGRAEIVGDTSLDQRYIVDDERRYSEITIPIYYANKVIGIIDSEHSRKYFYTGRHLSMLEKIAAICSSKIGRTLIEEKARRQEQEVQLLHKQLAEFRLVTLKSQMNPHFLFNCLNGIYHCILSSEIDKASAYLSNFAKLLRMVLLHSEKNFISLREEVELLGHYLRIEALRTSKPFEFSILIDEGIDPDTHHVPGMLIQPFLENAIWHGLMNKDGNRKLQIHWRRLKEEVLLCEILDNGVGRDQALRKREEGHVSKGMSLCMERVDLYKALFNTTFNIHIHDLYDEDGVPQGTKVNIAFGAGRENG
>NZ_CP043006.1|WP_148382956.1|909206_910235_+|phenylalanine--tRNA-ligase-subunit-alpha
MEQIVQQIEAYKQEIAAFEPKTAEELEQYRIRFLGTKGLVKTLFGEMKSVPNERKKEFGQVLNAFKQLAESRYEAFQQLKDDDAAAGHELDLTLPGEPHRLGTRHPISILRNKAIRIFERLGFSIAEGPEIEDDWHNFTALNLAENHPARDMQDTFYVNHHPDWLLRTHTSSVQARVMEQGKLPIRIICPGRVYRNETISARAHCFFHQIEGLYIAENVSFADLKQTLYYFVQEMFGKDFKVRFRPSYFPFTEPSAEMDISCLICGGEGCNVCKHTGWVEILGCGMVHPQILENCGIDSTKYTGYAFGIGIERLTMLKYQIKDLRLFSENDVRFLKQFQGTI
>NZ_CP043006.1|WP_148382957.1|910250_911093_+|3-hydroxybutyryl-CoA-dehydrogenase
MIHTIAVCGAGTMGAGIAQVSATAGYYTLLFDTRQEALDNGIAQISHNLRTAVKKGRLEEQRVPEILSRIRTVNDAQECIAEVIIEAIVESIPAKIALFNQLAEINHSDTIFATNTSSLSVSAIAQGIVNPARVAGMHFFNPAHLMQLVEIVSGKATHESITASLSELAKQMGKTPVHVKDAPGFIVNRVARHYYLEAMQIAEDGVCDIRTADRLLESAGFRMGPFALMDLIGNDVNYAVTCSLYEAFDKAPRFRPGQMQADKVARGELGRKTGKGFYEY
>NZ_CP043006.1|WP_148382958.1|911144_912140_+|NAD-dependent-epimerase/dehydratase-family-protein
MILVTGGSGFLGSYLLRSLVQAGTPVRALYRRQIPEQVNDIKNGVEWVQGDVLDTGALEDAMQGVEQVYHCAAVVSFQPDKRAEMLRINVEGTANVVNLALEYGIKKIVHVSSVAALGRARQQTDISEDATWEDSKNNSYYAISKHLSEMEIWRGIAEGLDAVIVNPSIILGSGFWHDGSGMMLKNAWKEFPYYTDGVNGFVDVHDVVDVMLRLMNSDITAQRFILSAENWAYRQLFNQMAEELGKKPPHIAAKPWMAELVWRMAKLKGMITGKRPLLTKETARTAQLRVYYSHDKILKALPDFRFRPLEHTVAEICAAYKAYRGASASST
>NZ_CP043006.1|WP_148382959.1|912142_912847_-|hypothetical-protein
MIKTFFRLAPALCLLLAACTSTKSVVQKKDPGLYLDAHELRVKIQDGWLTAKTISIGDYSTSSRTNGVAANTPAKQFRNVSDAFYFTVKATDVQVPVQVLSTPRITFSNRPMPEQLDALAGDVPLWYFHIGATVLEPLKSWELILKRSISFLELNENKPAGVLRSASDEIRVTAHNRFGIRNSYENTCYEFQLRGVPVAAVMTGDKPRAWIHPKADAALQQTLVAAMLAIVFKG
>NZ_CP043006.1|WP_148382960.1|912857_913799_-|UDP-3-O-(3-hydroxymyristoyl)glucosamine-N-acyltransferase
MKFEKPIPVKEIAAMIGAELSGNENLMATGINEIHKVETGDISFVDFEKYYNACLHSAATIIIINKKVAAPEGKALLVLDDPFSAYVSLVKRFRPFVPAHTPVSDTAVIGEGTVLQPNVFVGHHVRIGKNCIIHPNVTIYDHTIIGDNVIIHAGTVIGADAFYFKKRADREVMYDKLESCGRVIIEHDVEIGAGCTIDKGVSGDTIIGAGTRFDNMIHVGHGAVIGRNCLFAAQVGIGGKAIIEDNVILWGQVGVSKDLTIGKGAVVYAQSGVPASLEGGKVYFGSPVTDAREKQRELAWIKRIPEMWAKLNS
>NZ_CP043006.1|WP_148382961.1|914223_914928_-|cyclic-nucleotide-binding-domain-containing-protein
MLSDQTACRYCNKYMSDIFSASTPEHAAEIVHAKQCTLYKKGQVIFQEGAHPYGIYCINTGKIKLSHSGDEGRDQIIRLVKPGDLIGYKALISNEPYTATATVLEDSAVCFIPRDIFLLAMQKDASLSLRMMQILTSELRRAETKITHLAQKPVRERLAETLLTLKETYGLEADEQTINVTLSREEIANLVGTATESAIRLLSEFKKEKVIDLSGKKIRILRLQQLIKMANLQD
>NZ_CP043006.1|WP_168208654.1|914948_915590_+|pseudouridine-synthase
MDAAKLLIYSPLTKASILSLHYFAVYKPYEVLTRFGKEGDKAVLSDFFDVPRDVYPVGRLDYDSEGLLILTNDKTLNHRLLHPGQAHEREYWVQVDGAVTEKAIQQLKDGVTIRVDGRDHHVKALDAAIFASDPVVPERHPPIRFRKLIPAPWIRLVLKEGKNRQVRRMTAAVGFPTLRLIRYRIAQLHIGHMQPGDMIALSREELFNALQIH
>NZ_CP043006.1|WP_148382963.1|915645_916521_+|YicC-family-protein
MLKSMTGFGRAEVTRGETTITAEIKSLNGKQFEVNLKMSPLLKPYEFDIRNILQQELQRGTLDATINIKQNGATRPVVINTELARYYHQAISAMANDLSLPQEDMLNVLMKLPEVVTPASEQMEESEWLEVAKVIRTAVGDMDAHRIDEGAVLEKDLLLRIDNILLYTEKVKELDPLRKDRVRLRLETLLAEYVGKDNVDGNRLEQELIFYLEKLDISEELIRLQNHCRYFKDILAEADAAKGKKLGFVLQEIGREINTTGSKANDAGIQQWVVMMKDELEKAKEQVLNVL
>NZ_CP043006.1|WP_168208655.1|916544_917030_+|gliding-motility-lipoprotein-GldH
MKFRITCALLSMLAVACKPPRMETFEKNRDIPRQEWLTAYQPSFEVELAPEDTAFYYNIYVNVRHTDAYPYNNLWLLIRTLTPGDSTAGVRRVELPLADTYGKWLGNGLDDIFEHRIPIQQNALLSKPGLYRFSFEQNMRQDPLPYVMSVGLRVEKAAPRK

Crispr_ID: NZ_CP043006_2

• CRISPR_ID: NZ_CP043006_2
• CRISPR_location: 1028844-1028930
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_2

Consensus_repeat	Method
ATTAAAGGAGGCTTCATTATTAC	CRISPRCasFinder

spacers of NZ_CP043006_2

>2.1|1028867|41|NZ_CP043006|CRISPRCasFinder
GAACATCAGGTGCCGAAAGAAGGCATGACCACTGAAACCTA

CRISPR arrays and Neighbor proteins around NZ_CP043006_2

CRISPR arrays

The CRISPR arrays of NZ_CP043006_2

>merge|NZ_CP043006|2|1028844-1028930|CRISPRCasFinder
ATTAAAGGAGGCTTCATTATTACGAACATCAGGTGCCGAAAGAAGGCATGACCACTGAAACCTAATTAAAGGAGACTTCATTATTAC

>NZ_CP043006|2|2|1028844-1028930|CRISPRCasFinder
ATTAAAGGAGGCTTCATTATTAC	GAACATCAGGTGCCGAAAGAAGGCATGACCACTGAAACCTA
ATTAAAGGAGACTTCATTATTAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148383064.1|1024674_1025256_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
NZ_CP043006.1|WP_148383072.1|1035965_1037096_+|hypothetical-protein	unknown	unknown	gnl|CDD|224771
NZ_CP043006.1|WP_148383063.1|1023517_1024678_-|outer-membrane-beta-barrel-protein	unknown	unknown	gnl|CDD|372635
NZ_CP043006.1|WP_148383067.1|1029554_1029788_+|ferrous-iron-transport-protein-A	unknown	unknown	gnl|CDD|377199
NZ_CP043006.1|WP_148383057.1|1018622_1019216_-|cyclic-nucleotide-binding-domain-containing-protein	unknown	unknown	gnl|CDD|223736
NZ_CP043006.1|WP_148383066.1|1028998_1029421_-|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl|CDD|272871
NZ_CP043006.1|WP_148383074.1|1037706_1038063_-|septal-ring-lytic-transglycosylase-RlpA-family-protein	unknown	unknown	gnl|CDD|223868
NZ_CP043006.1|WP_148383073.1|1037122_1037653_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148383059.1|1020329_1020614_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148383070.1|1034241_1034745_+|DUF2480-family-protein	unknown	unknown	gnl|CDD|313799
NZ_CP043006.1|WP_148383058.1|1019343_1020111_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235816
NZ_CP043006.1|WP_148383069.1|1031929_1034047_+|hypothetical-protein	unknown	unknown	gnl|CDD|379299
NZ_CP043006.1|WP_168208662.1|1022078_1022960_+|carotenoid-biosynthesis-protein	unknown	unknown	gnl|CDD|367884
NZ_CP043006.1|WP_148389829.1|1015376_1017581_+|DNA-helicase-RecQ	unknown	unknown	gnl|CDD|223588
NZ_CP043006.1|WP_148383075.1|1038171_1038666_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP043006.1|WP_148383065.1|1025584_1027453_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl|CDD|235362
NZ_CP043006.1|WP_148383060.1|1020703_1022005_+|MFS-transporter	unknown	unknown	gnl|CDD|340925
NZ_CP043006.1|WP_148383068.1|1030165_1031173_-|quinolinate-synthase-NadA	unknown	unknown	gnl|CDD|236489
NZ_CP043006.1|WP_148383071.1|1034747_1035845_-|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl|CDD|213362
NZ_CP043006.1|WP_148383062.1|1022979_1023516_+|CopD-family-protein	unknown	unknown	gnl|CDD|367596

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148383064.1|1024674_1025256_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	6.61321e-34
NZ_CP043006.1|WP_148383072.1|1035965_1037096_+|hypothetical-protein	gnl|CDD|224771	COG1858, MauG, Cytochrome c peroxidase [Inorganic ion transport and metabolism].	2.22718e-09
NZ_CP043006.1|WP_148383063.1|1023517_1024678_-|outer-membrane-beta-barrel-protein	gnl|CDD|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	6.1755e-10
NZ_CP043006.1|WP_148383067.1|1029554_1029788_+|ferrous-iron-transport-protein-A	gnl|CDD|377199	pfam04023, FeoA, FeoA domain. This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	5.02452e-17
NZ_CP043006.1|WP_148383057.1|1018622_1019216_-|cyclic-nucleotide-binding-domain-containing-protein	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.04953e-22
NZ_CP043006.1|WP_148383075.1|1038171_1038666_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.54976e-14
NZ_CP043006.1|WP_148383074.1|1037706_1038063_-|septal-ring-lytic-transglycosylase-RlpA-family-protein	gnl|CDD|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	1.6373e-47
NZ_CP043006.1|WP_148383066.1|1028998_1029421_-|rRNA-maturation-RNase-YbeY	gnl|CDD|272871	TIGR00043, Endoribonuclease_YbeY, rRNA maturation RNase YbeY. This metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect. [Protein synthesis, Other].	1.44372e-25
NZ_CP043006.1|WP_148383070.1|1034241_1034745_+|DUF2480-family-protein	gnl|CDD|313799	pfam10652, DUF2480, Protein of unknown function (DUF2480). All the members of this family are uncharacterized proteins, but the environment in which they are found on the bacterial genome suggests a function as a glucose-6-phosphate isomerase (EC 5.3.1.9). This could not, however, be confirmed.	3.44211e-98
NZ_CP043006.1|WP_148383058.1|1019343_1020111_-|SDR-family-oxidoreductase	gnl|CDD|235816	PRK06500, PRK06500, SDR family oxidoreductase.	1.39755e-77
NZ_CP043006.1|WP_148383069.1|1031929_1034047_+|hypothetical-protein	gnl|CDD|379299	pfam13623, SurA_N_2, SurA N-terminal domain. This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	2.29052e-37
NZ_CP043006.1|WP_168208662.1|1022078_1022960_+|carotenoid-biosynthesis-protein	gnl|CDD|367884	pfam04240, Caroten_synth, Carotenoid biosynthesis protein. The representative member of this family is CruF, a C50 carotenoid 2',3'-hydratase involved in the synthesis of the C50 carotenoid bacterioruberin in the halophilic archaeon Haloarcula japonica.	7.38092e-06
NZ_CP043006.1|WP_148389829.1|1015376_1017581_+|DNA-helicase-RecQ	gnl|CDD|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	0
NZ_CP043006.1|WP_148383065.1|1025584_1027453_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl|CDD|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NZ_CP043006.1|WP_148383060.1|1020703_1022005_+|MFS-transporter	gnl|CDD|340925	cd17367, MFS_KgtP, Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters. This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0
NZ_CP043006.1|WP_148383068.1|1030165_1031173_-|quinolinate-synthase-NadA	gnl|CDD|236489	PRK09375, PRK09375, quinolinate synthase NadA.	0
NZ_CP043006.1|WP_148383071.1|1034747_1035845_-|magnesium/cobalt-transporter-CorA	gnl|CDD|213362	cd12828, TmCorA-like_1, Thermotoga maritima CorA_like subfamily. This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.93547e-144
NZ_CP043006.1|WP_148383062.1|1022979_1023516_+|CopD-family-protein	gnl|CDD|367596	pfam03653, UPF0093, Uncharacterized protein family (UPF0093).	3.58542e-44

Protein sequences

>NZ_CP043006.1|WP_148383065.1|1025584_1027453_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MFPSYDVIVVGAGHAGCEAAAAAANMGSRVLLVTMNMQTIAQMSCNPAMGGIAKGQIVREIDALGGYSGIVTDQSMIQFRMLNRSKGPAMWSPRVQNDRMLFAAKWREALENTSRVDFYQDMVKGLLVKNGVCHGVVTGLGHEIEAKAVVLTNGTFLNGVIHIGDKQFGGGRVAEKAATGITEQLLSLGLESDRLKTGTPPRIDGRSLDYSKMEEQKGDEEIVGFSYMDVEKIRPEQQRSCFITYTSEQVHDILRTGFDRSPMFQGRIQGTGPRYCPSIEDKINRFAERERHQLFVEPEGWNTVEIYVNGFSTSLPEDVQQKALRLVPGFENARMFRPGYAIEYDYFPPTQLQFSLETKQVSNLFFAGQINGTTGYEEAACQGLMAGINAHLKVREQEPLVLKRSEAYIGVLIDDLINKGTDEPYRMFTSRAEFRTLLRQDNADLRLTERSYKLGLATEERMQKMSDKLSGVEKAKTILKELALEPGEANAWLNSNNSAPLTQKQRAHQLLLRPGLDIISMKDHLPSVANALKDFGRDVLEQVEIQVKYDVYIEKENELVKRMSQLEDLVIPDAFDYSKLVSLSNEARQKFTKIKPRTLGQASRISGVNPSDVQILMVYMGR
>NZ_CP043006.1|WP_148383064.1|1024674_1025256_-|sigma-70-family-RNA-polymerase-sigma-factor
MQDISEIIEGCRQWSRSSQEALYRQFFGYAMAICLRYSNNKQEAIEILNDGFLKIFNHIDSYDISRPFKSWLSKIMANTAIDHLRSRKKISFSDDITQAYDLGVTDDAAMDKLSYDEILQLVQKLPPAYRTVFNLYVMEGFQHQEIAAMLGISEGTSKSNLFKAKRILKEKIEEQSSFNNYPDTGMIGATMQK
>NZ_CP043006.1|WP_148383063.1|1023517_1024678_-|outer-membrane-beta-barrel-protein
MSEQFENSIRKKLQDAEMPFDPAAWEQMKKRLDDPRRRRPVFFWWILSGLLIFIAAGSFWWWSGQQQTSAERPLTSIEDIPHSTTIPSPEKASGETEPLLPAVLPPASPGNPSSFAAEPSAPRRSVATVHHQKEKNNGDVDKEAVNLPGETEQVTVAQQSPGAATAKTDTSGQQLPAKVEETAAPVAAPADSLPEKKKRKGFEGGITIGPDVNIASSMKMGRVGLSTGIILRYHFNDRWSIQAGAVYSKKLYGATPKDYHFDYPVTYTKIDADCNVLDIPLNASYRFLTQPGGSWSLVAGASSYFMLNEKYDYFYENGTKRSHEYSNRNHHYFSVLNLGVNWEKRTTGMLQWSLQPYVKVPLGGVGEGRVKLYSAGLSLQVTMGKK
>NZ_CP043006.1|WP_148383062.1|1022979_1023516_+|CopD-family-protein
MYYFYIKALHIIFIVTWFAGLFYIVRLFVYHTEALAEEEPRRSILQDQFRIMMKRLWLGITWPSAILTLIFGPWMLILYGSIPGWMWVKLAFVAGLYGYHFFLHSIYKGFGQNKFRFTSTQLRVWNEVATLFLVAIVFLVVLKSMLSMVWAVAGLVIFAIVLMIAIRVYKSLREKKNR
>NZ_CP043006.1|WP_168208662.1|1022078_1022960_+|carotenoid-biosynthesis-protein
MYILFALCCMHAWKRGAGSMAYLLGGLGFGLLLEYVNVATSAGYVYGKFMLMLGVPPNDIPVCIGMGWAVIMYTARLVTDALHVPLWAAAAIDSLLAINIDLSMDVVAYRLHMWHWDWENRAGVEFSLTGGWFGIPYGNFYGWLLVVFYYSSFARLLEKTKLAKHTAWRILTPLLSILLSQIALYISLFPLSDWLKLLGVTSTHRFIAVLAIFALLAVAGLRQRKIQTGAKLPLVTWLVPAWFHVYFISWFFAAGFYQENGWMTFWSITNFIAGCIIHWLLYKTLTKRSTASI
>NZ_CP043006.1|WP_148383060.1|1020703_1022005_+|MFS-transporter
MTTNQIPQNATTAWRLKAIFTGSIGNLVEWYDWYAYAAFALYFAPVFFPTGNPTVQLLNTAAIFAVGFLMRPIGGWLFGSIADRQGRRTAMTLSVLLMSFGSFMIACTPSYKSIGIMAPVLLLLARLLQGLSVGGEYGTSATYLSEIATPDRRGFFSSFQYVTLIGGQLLALGIQLLLQKIFLTPEQLANWGWRIPFVIGAILALVALYLRRNMHESISLENKGKDRGSVIVLFTRHPKAVLTVVGLTLGGTIAFYTYTTYMQKFLVNTVKLSKENSTLISFSLMLIYAALQPFFGWLSDRIGRKPLLIGFGVLGTLFTVPILTAISVASSAWAAFFLILAALLIVSGYTSINAVVKAELFPAEVRALGVGLPYALTVAIFGGTAEYLALHFKNIGQESWYYWYVTACIFVSLLVYVTAKDSRKTSFIDKEQL
>NZ_CP043006.1|WP_148383059.1|1020329_1020614_-|hypothetical-protein
MQRMKSRRRHSKKQLRTKLTQLKRELRNMRTNVSIHRKPLSENLLKAGRLGEKLDQLWRQPVYFDELTALVRRYGGVLEAGGNTGDEFRERCGE
>NZ_CP043006.1|WP_148383058.1|1019343_1020111_-|SDR-family-oxidoreductase
MKLKDKVAVITGGNSGIGFGIAAAFSNEGATGTITGRNQETLDRSVKELGTGFMGIKGDVTNMDDLERIFKGTFDKFGKIDTLVVNAGGVVDGSPMAVITDVTEDNYDQYMDLNLKSSYFTVQKALPYLNDGASIILIGSSAAHRAAPGMTIYSAAKAAVISLAKGLSLDLLSRRIRVNALSPGSVDTPVFAKIVPQEQVDQVKQIWKDLTPAGRQGLPSDIGKAAAFLASDDSSFILGSEILSDGGLTNISLMK
>NZ_CP043006.1|WP_148383057.1|1018622_1019216_-|cyclic-nucleotide-binding-domain-containing-protein
MFESLAKYLVEKGSLTGDELRLVEEVTIPKKIRKHQYLLQEGDVSHFQSFVAKGCLRLYRVGEDGRDHIMRFAIENWWINDYSSYQSGQPSRYNIDALENSELLMIEKGKFNYLVETIPNFKNLIEQLTANNYEAHQNRIFSNISDTAEEKYDNFLRTYSTIYDRVPLHMIASFLGLSRETLSRVRQQHARKRRNDP
>NZ_CP043006.1|WP_148389829.1|1015376_1017581_+|DNA-helicase-RecQ
MAVAKVSLLDALHEHFGFDSFKGNQEKIIKNILSGKDTFVIMPTGGGKSLCYQLPALMSPGVALIVSPLIALMKNQVDLVRSYSSKDNVAHFLNSTLTKAQIKKVRTDLQSGKTKMLYVAPETLTKQENIDFFKELEISFIAVDEAHCISEWGHDFRPEYRRLKEMIDMISSKLPVIALTATATPKVQSDIVKNLELRSPEIFMSSFNRPNLYYEIRPKRKKDQTIREIVKFIHLHKGKSGIIYTLNRKTTEELADMLVANGIRAVAYHAGLDSGTRAQRQDMFLLEDVEVIVATIAFGMGIDKPDVRFVIHYNIPKSLENYYQETGRAGRDGLEGICVCFYSYQDVQKLEHLMRDKPLSEREMGAQLINETVAYAESAVCRRKVILHYFGEKYEQENCGKCDNCLNPKEKIEVKNRVVITLKAIQKLEERFGTDYVVNIITGKANPQITTFRHDKLDVFGEGKEFDAHFWNSLIRQMMLEGLIEKDIEEYGLLKITEKGRKFIKKPFSIWVALNHQFEEDTAAEEEDALSAEAQASADPVLFDMLKELRKKVAKEKNLPPFVIFLETSLEDMATQYPTTVQELEKIQGVSKGKAVRYGKVFVDVIARFVEENDIVKPDDFVMKSVVNKSGLKVFIIQNIDKKMPLETIAKNKELSIPQLLDEMETIVASGTKLNLDYCIDEELDDYAQDEIIEYFKGCETSSLQVAKDELTEGNYTIEQLKLMRIKFLVEYGN
>NZ_CP043006.1|WP_148383066.1|1028998_1029421_-|rRNA-maturation-RNase-YbeY
MVYFSAHEVKVGLKDRTRLKGFIRELFEREEQGLSNLQYVFCNDEYLLRINQEFLKHDTYTDIVTFELSPDPDITEGEIYISIDRVKENAERYEITENYELHRVMFHGALHLCGYRDKTKKEVEIMRQKEDEYLKLYFDK
>NZ_CP043006.1|WP_148383067.1|1029554_1029788_+|ferrous-iron-transport-protein-A
MIKLSSLMIGKSAVIREFEKSDVYIKLMEMGCVPGETVKVEKIAPLGDPICIIVAGYNLSLRKTEADNIWVEEILAV
>NZ_CP043006.1|WP_148383068.1|1030165_1031173_-|quinolinate-synthase-NadA
MITALSEAKKNLQKKGFLDMEVDVQLDLFSEIDRLKKEKNAIILAHYYQEPDIQDVADYIGDSLGLSQQAAKTDADIIVFAGVHFMAETAKILSPQKKVLLPDLKAGCSLADSAPPELFRKFREKYPDHIVISYINCSAGIKALSDIICTSSNAERIIESVPKDQPIIFAPDRNLGAYLIKKTGRDMVLWNGACMVHEIFSLEKITRLKMRHPEAKIIAHPECEAPVLAIADFIGSTTGLLKFTQRDDAQEYIVVTETGILHQMQKENPRKTFIPAPPNNACACNDCPHMKLNTLEKLYLCMEYEEPEITMDEKLRIAAKKPIDRMLDISAKAGL
>NZ_CP043006.1|WP_148383069.1|1031929_1034047_+|hypothetical-protein
MSVIQKIRDKYAVVIIVLICLAIVSFLLQDVFFGNNSMFSQPTEVGEVNGEELDYREYQQRIESMQERMRQQMQGASLDDQTQQYIREQAWDQFLREKIMQAQYDELGIAVTEAEITDQIYGKNPHPLVLQYFADPQTGEFDRSVLQRVAEQVKQDPTGQMSQQILAFDQMIAEYQRNQKYITLVHQGIHYPKWLAETEHAANAQNADISYVQVPYASIPDSTIKVTDAELNKYIQENKALFQVEDNRKIEYVAFNALASAADSALAFEEFEKLKAELDTTPDVAGFIKLNSELPFYDGYAPRNTIQVPAKDSIIDLPAGKIYGPYQDNNLLVFAKVLDRKTLPDTVKIREILIAIQPGVSDSLAKKRADSLEAVIRGGGDFAALALQFSDDPNSKQNGGEYTLTPNGYFANELQAVKDFAFEGNSGALKVVKMPIGYAVVKITEQKNFGPALKIAYLAKRVDASPATSSEALALANDFASKNGDWKTFQKTVEEKGLDKRRQDNIGPMDFVLPGLGSAREIVSWAYNADKGDVSPVFTLEDKFVVAVLTGAREAGTAPLDEVRPQVEAEVRKNKKADQIIAKMKSPETIEAAASATNQPVLTAEAISFASPFIPSLGFEPRVSGAAFNKAWGTAKSTAPIQGNSGVYVLKVSNYVPSGQPALDYPQQSAAYVQNLRQAVDNRLFEALKKKSDIKDNRASFFTAN
>NZ_CP043006.1|WP_148383070.1|1034241_1034745_+|DUF2480-family-protein
MEEIVNKVAQSALTTIDLEKFYPQGETAVFDLKDHLFMELILKEKEFRAALQGLDWEVYRGKNVAIVCTADAIIPIWAYMLVAAYLEPVAAFYAFGDEEFVHKTLFLKNIATIDPEQYRDGRVVIKGCGDKTITEAAYVEVTRLLRPVVKSIMYGEPCSTVPVFKKK
>NZ_CP043006.1|WP_148383071.1|1034747_1035845_-|magnesium/cobalt-transporter-CorA
MAKRGLLPIPDVINPFKVRKKRLMNFNPVTAATSRKPVDHVKVTVFEYDAQTVREEVMEQVEDCLRFSKGDCVKWINVDGVRRQEVEAICRGFNIHHLLMEDIMSEGQRAKMDEIGDSLFCLLPMMSFRAESASVDQEQVSLLLLNNVVISFQDDPGRDVFNPIRERLRSNGTKIRNSGADYLLYALLDEIVDNYFMVMDSLGERVELLEEIIPRQPNNRTLARINYLRKEILLFKRGIAPVRELTNGLLKSESSLIDESTYKYFKDVYDHIVQANDLADNYRDMVMNLQELYHAQMSQKLNEVMKVLAVVTTLLAPLTVITGIYGMNFERMPELRNPNGYFIVLGVMLFIFSAMIIIFRKRGWF
>NZ_CP043006.1|WP_148383072.1|1035965_1037096_+|hypothetical-protein
MAATLFSVISGQRARHLSPQARHTWSWYQLQLRQLEKEAGFLLESVQQQDSDPEIQQQFLETRRVYKRLELLLEYFQPAAAAMLNDPQRSSGLGALETKLFPFIREKDTGGIRAVSEKMLSGIRALRAEADSLSVGDAQLFDAMRQEIVRILAFGISGADSPLAQESMLETRSALNGIKAVWLFYQEKLEKRNPELVEHTLELFAGARRMLDTATGFDTFSRAEFINDYLNPLSVRIKLAREALKIPYADSVAFLDPAASHVFARGAFPFSAEEEAATRMESRFDRFMRGNGEQLDRKEIRGFNLFMGKAKCGTCHIAPLFNGQDPLSGNDTHNATAVILRNYRDTISGMHYSRQLTSGEQQDVIAFVRSLHDVEI
>NZ_CP043006.1|WP_148383073.1|1037122_1037653_-|hypothetical-protein
MDTWFTLPTVSNERPAMTNLPVYPDFTLTLTGDDWRQAEFINIDKLCCAGEEMDEIKDIRINYSREIADGQRSFFRTHVRQRIGPADLFIPLFELKAILRTQVVGSIAWEIQSGFVKHGFALSTPSGCYYGLEENGIVKTLGLLEVGESSEKTIRRLVKTYHLIFVHWCGCIIQTP
>NZ_CP043006.1|WP_148383074.1|1037706_1038063_-|septal-ring-lytic-transglycosylase-RlpA-family-protein
MNHSLVLLSIISLFLFSSCARKITENGKASYYADKFQGRKTASGEIFRQRRMTAAHKTIPFGTKVKVTNLSNGRTIKVRINDRGPFVAGRIIDLSRKAAGRLGMLNAGVVNVKIRYKK
>NZ_CP043006.1|WP_148383075.1|1038171_1038666_-|GNAT-family-N-acetyltransferase
MLTIARAGEEQIPVIQQIAYDTWPDTFRDILSPEQIRYMLHMMYHENALLQQMRSGHVFLLAEWSGMPGGFAAYELNYHHQPVSKLHKIYVLPSMQGKQVGKALLQEVSRIAGEAGMQQVWLNVNRENKATGFYERFGFIKTGEEDIDIGNGYFMNDTIMQLTL

Crispr_ID: NZ_CP043006_3

• CRISPR_ID: NZ_CP043006_3
• CRISPR_location: 1666836-1667210
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 7 spacers

Consensus repeat of NZ_CP043006_3

Consensus_repeat	Method
GGCGGTGGTGGNTACNNN	CRT

spacers of NZ_CP043006_3

>3.1|1666854|42|NZ_CP043006|CRT
CGTGATCGTGACGGCGGCGGCTATAACCGCGACCGTGGCGAA
>3.2|1666914|30|NZ_CP043006|CRT
GGCGGTTACGACCGTGGCGGCGGTGGTTAT
>3.3|1666962|36|NZ_CP043006|CRT
TACAACCGCGGCGGCGGCGGATATGATCGCGGCGGC
>3.4|1667016|30|NZ_CP043006|CRT
CGTGGCGGTGGTGGCGGTTACGATCGCGGT
>3.5|1667064|24|NZ_CP043006|CRT
GGCGGCGGCGGATACAACCGTGGC
>3.6|1667106|33|NZ_CP043006|CRT
CGCGGCGGTGGCGGCGGCGGTTATGACCGTGGC
>3.7|1667157|36|NZ_CP043006|CRT
CGTGGCGGTGGCGGCGGTGGATATAATCGCGGCGGC

CRISPR arrays and Neighbor proteins around NZ_CP043006_3

CRISPR arrays

The CRISPR arrays of NZ_CP043006_3

>merge|NZ_CP043006|3|1666836-1667210|CRT
GGCGGCGGTGGTTACAATCGTGATCGTGACGGCGGCGGCTATAACCGCGACCGTGGCGAAGGCGGTGGTGGCTACGGCGGCGGTTACGACCGTGGCGGCGGTGGTTATGACCGTGGTGGCGGCGGGTACAACCGCGGCGGCGGCGGATATGATCGCGGCGGCGGTGGTGGTGGCTACGACCGTGGCGGTGGTGGCGGTTACGATCGCGGTGGCGGTGGTGGCTATGGCGGCGGCGGCGGATACAACCGTGGCGGCGGTGGTGGTTACGATCGCGGCGGTGGCGGCGGCGGTTATGACCGTGGCGGCGGCGGTGGATACAACCGTGGCGGTGGCGGCGGTGGATATAATCGCGGCGGCGGCGGTGGTGGCTTCAAC

>NZ_CP043006|3|1|1666836-1667210|CRT
GGCGGCGGTGGTTACAAT	CGTGATCGTGACGGCGGCGGCTATAACCGCGACCGTGGCGAA
GGCGGTGGTGGCTACGGC	GGCGGTTACGACCGTGGCGGCGGTGGTTAT
GACCGTGGTGGCGGCGGG	TACAACCGCGGCGGCGGCGGATATGATCGCGGCGGC
GGTGGTGGTGGCTACGAC	CGTGGCGGTGGTGGCGGTTACGATCGCGGT
GGCGGTGGTGGCTATGGC	GGCGGCGGCGGATACAACCGTGGC
GGCGGTGGTGGTTACGAT	CGCGGCGGTGGCGGCGGCGGTTATGACCGTGGC
GGCGGCGGTGGATACAAC	CGTGGCGGTGGCGGCGGTGGATATAATCGCGGCGGC
GGCGGTGGTGGCTTCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148389859.1|1667312_1667858_+|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl|CDD|379265
NZ_CP043006.1|WP_148383571.1|1683820_1684975_-|DUF4974-domain-containing-protein	unknown	unknown	gnl|CDD|226235
NZ_CP043006.1|WP_148383556.1|1656005_1656650_-|DUF502-domain-containing-protein	unknown	unknown	gnl|CDD|225480
NZ_CP043006.1|WP_148383558.1|1657447_1658809_+|TolC-family-protein	unknown	unknown	gnl|CDD|224455
NZ_CP043006.1|WP_148383567.1|1675441_1675942_+|DUF1735-domain-containing-protein	unknown	unknown	gnl|CDD|378016
NZ_CP043006.1|WP_148389858.1|1654947_1655886_-|S1/P1-Nuclease	unknown	unknown	gnl|CDD|211380
NZ_CP043006.1|WP_168208708.1|1670314_1673788_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_168208710.1|1680152_1683533_-|TonB-dependent-receptor	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148383562.1|1664914_1665706_+|TIGR00266-family-protein	unknown	unknown	gnl|CDD|376704
NZ_CP043006.1|WP_148383560.1|1659989_1663538_+|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl|CDD|223911
NZ_CP043006.1|WP_168208706.1|1663790_1664879_+|hydrolase	unknown	unknown	gnl|CDD|317058
NZ_CP043006.1|WP_148389857.1|1653705_1654776_-|3-phosphoserine/phosphohydroxythreonine-transaminase	unknown	unknown	gnl|CDD|235428
NZ_CP043006.1|WP_148383563.1|1668055_1668652_+|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl|CDD|274376
NZ_CP043006.1|WP_168208707.1|1668734_1669901_+|DUF4974-domain-containing-protein	unknown	unknown	gnl|CDD|226235
NZ_CP043006.1|WP_148383568.1|1676078_1676666_+|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl|CDD|274376
NZ_CP043006.1|WP_148383557.1|1656819_1657431_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP043006.1|WP_148383559.1|1658845_1659955_+|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NZ_CP043006.1|WP_148383569.1|1678445_1680143_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
NZ_CP043006.1|WP_168208709.1|1673798_1675418_+|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl|CDD|378943
NZ_CP043006.1|WP_168208705.1|1663627_1663765_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148389859.1|1667312_1667858_+|2'-5'-RNA-ligase-family-protein	gnl|CDD|379265	pfam13563, 2_5_RNA_ligase2, 2'-5' RNA ligase superfamily. This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	2.99516e-30
NZ_CP043006.1|WP_148383571.1|1683820_1684975_-|DUF4974-domain-containing-protein	gnl|CDD|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	4.04463e-25
NZ_CP043006.1|WP_148383556.1|1656005_1656650_-|DUF502-domain-containing-protein	gnl|CDD|225480	COG2928, COG2928, Uncharacterized conserved protein [Function unknown].	3.25074e-30
NZ_CP043006.1|WP_148383558.1|1657447_1658809_+|TolC-family-protein	gnl|CDD|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	3.72513e-36
NZ_CP043006.1|WP_148383567.1|1675441_1675942_+|DUF1735-domain-containing-protein	gnl|CDD|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	1.61949e-11
NZ_CP043006.1|WP_148389858.1|1654947_1655886_-|S1/P1-Nuclease	gnl|CDD|211380	cd10981, ZnPC_S1P1, Zinc dependent phospholipase C/S1-P1 nuclease. This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.	1.01084e-68
NZ_CP043006.1|WP_168208708.1|1670314_1673788_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	2.13241e-103
NZ_CP043006.1|WP_168208710.1|1680152_1683533_-|TonB-dependent-receptor	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_148383562.1|1664914_1665706_+|TIGR00266-family-protein	gnl|CDD|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	7.89945e-84
NZ_CP043006.1|WP_148383560.1|1659989_1663538_+|efflux-RND-transporter-permease-subunit	gnl|CDD|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP043006.1|WP_168208706.1|1663790_1664879_+|hydrolase	gnl|CDD|317058	pfam14606, Lipase_GDSL_3, GDSL-like Lipase/Acylhydrolase family.	9.62856e-77
NZ_CP043006.1|WP_148389857.1|1653705_1654776_-|3-phosphoserine/phosphohydroxythreonine-transaminase	gnl|CDD|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0
NZ_CP043006.1|WP_148383563.1|1668055_1668652_+|RNA-polymerase-sigma-70-factor	gnl|CDD|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	5.58125e-44
NZ_CP043006.1|WP_168208707.1|1668734_1669901_+|DUF4974-domain-containing-protein	gnl|CDD|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	2.61418e-24
NZ_CP043006.1|WP_148383568.1|1676078_1676666_+|RNA-polymerase-sigma-70-factor	gnl|CDD|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	4.47932e-43
NZ_CP043006.1|WP_148383557.1|1656819_1657431_+|TetR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.97868e-11
NZ_CP043006.1|WP_148383559.1|1658845_1659955_+|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	1.96088e-51
NZ_CP043006.1|WP_148383569.1|1678445_1680143_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	1.58299e-39
NZ_CP043006.1|WP_168208709.1|1673798_1675418_+|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl|CDD|378943	pfam12771, SusD-like_2, Starch-binding associating with outer membrane. SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	1.08009e-42

Protein sequences

>NZ_CP043006.1|WP_148383562.1|1664914_1665706_+|TIGR00266-family-protein
MLKNHEIDYRIHGEEMQIVEIELDPQESAVAESGSFMMMDGEIRMETLFGDGSGRQQGIFGKLMSAGKRLITGESLFITAFTNVGQGKKRVSFAAPYPGKIIPMDLSLLGGKIVCQKDAFLCAARGVNVGIEFQRRLGTGIFGGEGFIMQKLEGDGLAFVHAGGLVVEKELQPGELLKVDTGCVVAYTQQIDFDIEFIRGIRNMVFGGEGLFFAVLRGPGKVWLQSLPISRLASRVLAYGTGPRKEEGSILGGLGNLLDGDGR
>NZ_CP043006.1|WP_168208706.1|1663790_1664879_+|hydrolase
MKYSLAFLLSLLLCGATVAFARQQDTTRYTDARELLIIGKALPTNPVWVRWDSSQSIPMTPAVKSLARHSAGIAVLFETNSTYLRVKWSVAQRKFYNNITPIAHSGLDLYAMENGRWQFVNTARPGDRETSFAYPVVSNMDGATRQYMLYLPIYNELTSLEIGVSPQAMLAKPVKPGIDTTRRIVIYGSSILQGASASRAGMTYPSIISRRTSWEMVNLGFSGNGKMEFPVAELLATMPAAVFVLDCIPNPTPAEIRERAYPFIKHLLDKRPEVPVLLVETSNRETGFFDRKIGDVVREKNRLIREVYEQLRKEGYKQLHYLRGADLIGHDHEGTIDGTHNTDIGFMRQAEVILPVLKKLMK
>NZ_CP043006.1|WP_168208705.1|1663627_1663765_-|hypothetical-protein
MFKLRYRGFPENKRGAERFPVNASAAGCASSQSFALGASFHRQPA
>NZ_CP043006.1|WP_148383560.1|1659989_1663538_+|efflux-RND-transporter-permease-subunit
MKDLEKEFKPTSWSIDNKVSIYVITIIISIAGILSYQALPKEQFPEVVFPQFYISTVYDGTSPEDMETLITKPIEKKLKSISGVKKISSSSVQDYSAINIEFDADQDIEAARQEVREKVDEAKSELPSDLEDDPQIIKIDVSQIPIMNVNLSGDFDLQTLKKYADDMQDRIESLNEITRVDIVGALEREIQINLDKYKMEAARVSFEDVIGAVANENRTVTGGLVSMNGQKRTLSVKGEYKDPLKIRDIVIRSASGSVVYLRDIAEVVDGFEEQESYARLDGKSVITLNVIKRSGQNLIDASDKIFKIVDEMKESTLPKGLDVTITADQSESTRVTLHDLINTIIIGFILVTFVLMFFMGAVNAIFVAASVPISMFIAFIIMPGLGFTLNMMVLFSFLLALGIVVDDAIVVIENVHRIFYERKDLGIVKAAKIAAGEVFMPVLSGTLTVLAPFVPLLFWPGIIGSFMYFLPMTLIVTLLASLFVAYIINPVFAVDFMDRHEGENHPKPKFDRKFKVLTAVFFFVALIGYMSSFGVGNFVVCIYLLIVLERFWLGGVARKFQNGFWPRVQNRYRRILSWCIVGWRPVKILFATFGLLLFSIMITGLRNPKVVFFPQADPNFIYAYIELPIGTDQKYTDSITNIIEQRITKVVDGKNNPLVKSIISNVAVGAGDPSQMDLSVQPNKGKVTVAFVEFAKRDGQSTVEYLDKIRDAVKGVPGADITVEQEQGGPPTGKPINIEISGDEFELLATTSERIKRYLDSLQIGGVEELKSDFQSNKPEIIVNIDRERANREGISTVQIQNAIRIAQYGVEASKFRDPEDDYPIRVRLKEDQRNNINTLMNLQITYRDMNMGGQIRQVPLSAVADIEYSNTYAGIKHIDEKRVVTLYSNILTGYNANEVVAAITQAVQEFSPPDGITVKMTGEQEDQLETMNFLLMAMLGAVGLIFMIMVAQFNSVGRALVIFLEILFSIIGVFLGFAIFGMDISIVMTGVGIMALAGIVARNGIVLVEFTDLLVQQGVHINEAVVEAGRTRMTPVLLTAIAAILGLIPLAVGLNIDFAALFSEFNPHIFFGGDNVAFWGPLAWTMVFGLVFATFLTLILVPVMYAMNKRVIDVLDHYKLPRGLKYVPFLVLILKIFLKKETIRKMHDPEYESPRPYNFFNGHADEADKEQAKQAKGVAIH
>NZ_CP043006.1|WP_148383559.1|1658845_1659955_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MTRKYFTLPLITLILAACGGEGGNKAEQLQKLKQEKTALDQKITALEKELKAGDSSVKMKTVTIAPLETTTFEHYLDIQGQVDARENVNVSPQQPGIIKSILVREGQQVSKGQTLAQLDNQVLRASIAELQTRIDLAKIMYEKQENLWKQQIGSEVQYLNAKNQYESLLKSKKTMEEQADLTRITSPINGTVDAVIAKLGDNAAPGMPAFRVVNSTNLRVVANIAESFGGRVKTGDEVILSFPDINKEIRTRIGFASKVIDPLSRTINVEIPLKADKDIRPNMIVRLRIVDYKANDAIVIPVSVIQYSMGKPYVLTVKGQGKELQAVRKNIEMGRTYNDKAEVKSGLTAGERIITTGFQGLNNDDYVKL
>NZ_CP043006.1|WP_148383558.1|1657447_1658809_+|TolC-family-protein
MHFKWKLIALTGTMMQFLTYAYAQQQPDPGTTMRFSAKQAVDYALANQYAVRNARLDELKQLAINKEVSGLALPQVSASGTFQDNPIIQKQLLDASNFDTSAPKGTLVPFEFGLKYNALGTVNVNQVLFDPSVLVALQARKTLEELAHRGIKKAEVDVKAEVYKAYYNVVAADKALSILQENITRMRKSLDETREIYKNGLVEKLDVDRLVVQMNNLTTQEVSLRNLRDVGIAALKYQMGMPIKQPLELTDTLSTDEIKSVLVENESFVYQSRVEYMLLESQKKANEYNLKRYKLQALPTLSAFGTGGISRQSNQFDYFQSELWYGYTSWGLNLSIPIFSGMQRRRKVDQAWIDVKKSELDLENMRNVIDLDQVQSATTLRNNIKTLESQEENMQLAQEVMRMTDIKYKEGVGSSLEVITAETSLLTAQNNYFSALFEAMVSRIDYLKAYGKL
>NZ_CP043006.1|WP_148383557.1|1656819_1657431_+|TetR-family-transcriptional-regulator
MEVQERILDTAFHLFRQYGTRSITMDDIAVRMGISKKTLYAHFADKSDLVMNVMDRHLKLMQAQCIESRTQAKDAVEELFLVMKMLEERLRNMNPVAMMDLQKFHAKAFRLFEDHKNVFMLDMVRQNLQRGIEEGLFRPDLELDILAHFRTASAMFCFQPELFPMNGYDMTKVQRVLLEHFLYGVATLKGYKEIEKYKNERLP
>NZ_CP043006.1|WP_148383556.1|1656005_1656650_-|DUF502-domain-containing-protein
MSPKLRFKVLVSRILRYFFQGLLILAPIGITAFTLYWGFITIDNLLPRDLIPTNHPMNFLRYQGVGFAIVLILIIFVGYVSSSFIVGRLIDMFDHILERTPFIKYIYSSVKDVFDAFVGEKKKFDHPVLVNVYGEDVWEMGFITQKDVKSLGLEGFLAVYVPHAYAITGKVFIVRQEKVRPLTNISAGEAMKFAVSGGVTHITEMPAQPVEPGR
>NZ_CP043006.1|WP_148389858.1|1654947_1655886_-|S1/P1-Nuclease
MLAALFLLRSPSRAWGFFGHERINRLAVFSLPPEMMVLYKPHIEYIMQQSTAPDKRRYMIPEEGPRHYLDVDHYGFLNIPRTWPQAVEKFTADTLQRYGMLPWHLERMMAQLTKAFLAGDGPRILRLSAELGHYMADAHVPLHACSNHNGQFTGQHGIHGLWESRIPELLADSRFDYWTGRAAYIRDFRAFAWQVIGESARASDTVLWLEKQLSLSFPADRRYAYEIRKGVLVRNYSSEYTRAYQALLGDMVERRMRGSIAAVAACWYTAWADAGQPSLATLAPGSPTVQEQEALRQMDSLWQQGKIFGREH
>NZ_CP043006.1|WP_148389857.1|1653705_1654776_-|3-phosphoserine/phosphohydroxythreonine-transaminase
MKVHNFNAGPSVLPNEVLYKASKALIDFDGTGMSILEIGHRTEQFTAVMEEARSLTRELMQLDDDFEVLFLHGGATTEFMQVPMNLLDSGETAAYIDTGVWSNKAIKEAKQFGYVDVIASSKETNYHHIPKQFTVPQQAKYLHITTNNTIYGTQWQTIPDTDVPLIADMSSDILSRQMDFNRFALIYAGVQKNMGAAGATMVAVRKSMLGKVTRKIPSILDYRLHIENGSMLNTPPVFAVYITMLTLRWLKGQGGVAAIEKINNKKAALLYDEIDHNPLFRGNVVKEDRSRMNVTFTIDKPELEEEFLKFCKKEDIVGIKGHRLSGGFRASLYNALPLESVEVMVEAMKFFSLKKA
>NZ_CP043006.1|WP_148389859.1|1667312_1667858_+|2'-5'-RNA-ligase-family-protein
MYFIALLPTAEVGKEIIKIKQDFAEQYGPTYALKVLPHITLQVPFTADPSLERAFCEELTEFAKTQAPFEVSLNGFGTFPNKQNRVLFINVEKSETMSAMHRQLINFLRKEFGFSTMLARTGFTPHVTVAFKDLDDAQFEKAWPEYENKEYTATFKVNNLYFLRHNGKSWEVLQKCKLGGA
>NZ_CP043006.1|WP_148383563.1|1668055_1668652_+|RNA-polymerase-sigma-70-factor
MQDPSLIEKNILLLVAEGDRAAFNSLLHTCWNKVYTLSLTYLRSVEDAQEITQDVFLKVWQSRSQLPAIRNFDGWLFVLTRNEVLSELRKKKVRPVISAEPGEREEDTILPDHPLIYKEASAFIAKGIAALPPMRKKVFMLSRMEGKSYEEIATLLQISRNGVKDHIVKALHFLRNYLHEHEGDVLLLILLFMQHMKS
>NZ_CP043006.1|WP_168208707.1|1668734_1669901_+|DUF4974-domain-containing-protein
MSETRFSALLELYVTGRLSAADKAEFFQMLHSGHYDEQLEQIMEEDWRTGRYEEEENQLLRSLIAEKVNFRIDSELADKKAVRPRISWLQSPWLRYAAVLALLLSIGAYFWLQQRPAGNTAVADVAPGGTKAILTLQDGSAIPLDSTGRQSIRQGRSTVLQQGGQLQYDVQGKADVILHNTLTTPRGGQFRIILPDGSKVWLNAASSIRYPTAFAGKERLVEVSGEVYFEIAPDAQMPFVVKMQQGNRVEVLGTHFNLNAYTDEPAIQTTLLEGAVRVSNATGNAVLSPGQQALVSPDNSIRVVPHRNAAQVVAWKDGLFNFEGATLEDVMRQLARWYDIDIVYEKGIPPIGFGGKIERDLTLTGVLKVLQTAGVHFRLEGKRLVVMP
>NZ_CP043006.1|WP_168208708.1|1670314_1673788_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKLTAILLITALLGAHASVRSQTVTFTGQRADLRKIFSVIEEQTGYVVFYNIGLLKDAKPVTVSAQDMPLDLFLNKILYQQSLNYNFNNKTIVLFRDADIIARLHAQIPVLTDLKGQVLDMEGNPVPGATIAVKGSSKATSALGDGSFALTGIPDDVTIIISAVGFTPTEIGIRNGIPFKKGKTGNVSPRDDGGWMIRLVKSDIKLNEVQITAYNIEKRTKELGYSIARVSGEEINKANSGNVLTGLIGKVSGMTITTQSSDMTPEMRILVRGIRSFGQNSNNQPMFILNGAPLSFGTDQSAAQQVMSFINNINPADIDNVTVLKGANGTALYGPEGINGVIIITTKKGQMGKPAINFRNNTSFQRVDYRRERRQRTYGIGSGLTDEFGNGIYDARSTYGWGPAYDGSMVPIGYPDENGELQRVPYRDTKDARKFFQVAKTVRNNLSFSSSDARSSFYLGLGHAMQTGLLPKDKQNQSTILLNTSRNFGVIDIRLNINYAHTSDDRGPDITSNVRGLPTFIPILQYSDYINDHWSHQDRYWNGISPYQQIDNRRTRSTVNAVSGNLILEVKPFSWLSIRDQPGINYTGTYAKSTSAPLYFSDFAAQDYNKMYDRFATVGEDMSVSTSINNDFVISTIHHPGNFLIRTNVGNTIRENYYKQLKAGAELVVPVYNLAFTSYGLFPEEVAVLSRSWSLFGNVTAGYKDRIFLELTGRNEWDSKRAKIARGQDMYFGVNTSAVLSEIFPSLRDWKWLTTARLRASVAQSANMNIVPYQAERTLGLMGGYPYQDNSTGDYLLGYAFYPGNPNPLLKPERVISQEYGGNFSFLNDRITVDATYYYQRNNSVILNVDNAWLSGYPSIDNAGSFRNNGFEFDLKVDPLFQLPNKMALSVEGRFAINDNKVLYLTDVYGGLFPVSDGAGQKYYAQEGSQAFSFAFRDWVRDPQGRVIVDKVTGLPEAQGYEEFSLRGRTLPKYAASVGLNFNWKNFSASILLDYLGGYEHKFSTDYDLWAGLHTLTTLNGRERFVFPHSVYDDGFGKYVENKDVVVNSANQELYSRFEQVSLHGLTSAAFWKLREVAFQYVLPFKRGILKDVTCSLYGRDLFSIYPRSNINGDPGLIKGPGQRQFSSVPNNLSGGSSDNTALPGTVLYGFTAGLKF
>NZ_CP043006.1|WP_168208709.1|1673798_1675418_+|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MRFLYRIWSYLLCMVLLTASCKKGWLDVNYNPRDLTDTEATPDQVLAPLMESSIASKDTRFLQHWMGYWAYYQFPPGHTVVTYNRTEAEPGVFSAAISPEIKFLETRSQELGQTFYTGIAKVLRVVQFQRAVDVLNNMPYTDAFNSSVLQPRYDDAMAIYEELMRELDRASDLISHAKPEQNLKISSTDIMFHGDQVSWLKFINTLRLRLLIHQANRTDRAAYIAAEMEKITSEGSGFLESGQDASVNPGYVIRKQLSYYFGCYSNHNQHGGGDYDAVLQIGSYHWSHANIYAMNLLKADNDPRLELFYSSIDLPVPAGAPEPFPQPGRQDFRGNRFGDYVNSSLYPYQDVTYISAVGGSRNNDVVSPAAKGIIKGRDMADWVMTSVESKFLQAEAVQRGWLPGDAENAYKDAVKESFRWLNAGGNTSMPELSDAIFDTWYIQQAANPNVSWAAAPDKYKLLMFQKYMAFNGIEPLETWTDYRRNGRFPDLPVSASPQRVGNAIPFRLLYNSNEYIVNPKNVNAQGQLDIFTSKIWWMP
>NZ_CP043006.1|WP_148383567.1|1675441_1675942_+|DUF1735-domain-containing-protein
MKQIILFFLILFVLPGCLKNEVTLDYTGIQPIVLIPNANWPVKGYASQPEDSAAGTVQLNLYAKVSYEKPLDKNVLVKFTLDNALADAYNDQWGTAYRLLSADCYEVSSLDLVIPSGAQQAILPITIISEKIDPQYDYILPFTIAAADGNTVASNFKSMIFTLKGQ
>NZ_CP043006.1|WP_148383568.1|1676078_1676666_+|RNA-polymerase-sigma-70-factor
MELSDLELILLWQKGEERAFEMIYKRYAVQLLSIAYRKVGERDIAEDIVQEAFITLFKNKESANTIASLFAYLYVTLKNKILDAYRRDALQKKYAQHANIRFEVEDNSPYFQIETRDLEKKLESEIEKLPPQCGKVFKLSRQKHLSNKEIALQLGISENTVEQHMRKALRILRGNLLYYDKSIMLLIVMAYECLQ
>NZ_CP043006.1|WP_148383569.1|1678445_1680143_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKSTNLIHHKKARTGILLCMALLMYTGCKSELDLVSEDSITDGIFWKTPNDFKLGANQLYNGLDRFGFEDTESDIAFNDPNSVSNGTYQPTETSGQWTGSYNNIRSANNVIEKGAGTTDPLIKRYVAEARFFRAWYYYKLMRVFGGVPLITKVLNTGDAELFTPRSTRTETVDFILKDLEDASADLQLQGELAGGDIGRITRGAALSLAARVALFEGTWQKFHGEGDANKYLDAAITAATTVMTSGQYGLYTGSAGQSYRYLFLEPGDDSRECILDRRYARNILGHDMPYAYDQSGYNPTRKLVDMYLDDTGLPITHPASVFHGYATFSSEFADRDPRMTMTMIIPGTLTNRVFNPVTKVENWPDKPQRNFNTGYILYKYMSEDATANNSGRMGDASLFEFDRHLIRYAEVLLIYAEAKFERNGAITDADLNMSVNLLRDRVDMPHLTNAFVTTNGLDMREEIRRERTIELALEGFRYDDLRRWKTAETVLPQDVKGIKIKGTDWETRAPYSDPVYQNRTDANGFLIAESNRIFDPAKHYWQPLPTKEVAFYLASGYSLPQNPEW
>NZ_CP043006.1|WP_168208710.1|1680152_1683533_-|TonB-dependent-receptor
MKLIFLLLTATFLQVRAESYAQKVTVIVKDASLSEVIAKLRKQTSYDFLYNNATLEHAKPITIHAKGMPIMRFLDSCFRDQPFEYQVRNNTILIMQKTPRAPELVTASQRQQLTGVVRDTITGEVLIGVSVGVEGSSTGTSTDENGAFSLNLPGPSAALVVSYIGYETKRVVISGQTQITILLKKANTKLDEVVVVGYGTRTKGAVTGAISTVNSEVFENRPLNNSFDALQGTLPGVTITRASGQPGNQGYTLQTRGYSSINGNVPLVMIDGIPGDLNVINPNDIANITVLKDAAASIYGARAADGVILVTTKKGRKGPPEVLYTLNLGLKKPTYLRKITNTLQFAEMLDEGLRTVGQAGFDPSVFEKIKANAPVEPNGGWNYGVTNYPGFYGYTDWNKEIYKNSSQQIHNISVSGGGENNSYLLSLGYNRDNGNLRFGENNMDRYNMRLNYDFRLLEGLTVETRTSFENQVTREPSNLGNALTNVPRQFPYAPVHNPEGQFYGYQGYENPAQTLAETGKRNINYSRFTTNLKIDYAVMEGLKLTGQASVKMDYYNDHANYRTFTRWNYAGDVQDVRQNPNSAYYQNTKTLNKLYQVYFDYTKRFAGTHGINLTGGASLEQNNASGQTTWGYNFLSNDIFTLNLADRTQTAYANFTGSLTNSALASYFGRLSYDYKEKIILDITARADGSSKFAPDKRWSAVFPSVALAYNLTQERFLEPLHIFDMLKLRVSWGKMGNQEIGSLGLYDYIPLVSIGGNYPIGSPNAGLTGANSNPASADRTWETIENRNIGLDVAVLQSRLSFTFDYFTKINDDMLVGIAVPATYGGSPPSSNQGRLVTRGFETALTWKDQINDFRYSVMLQLSDSKNKLVELKNSDNYSEGLNFVREGYSIYSYFGYEYAGIIRTQKELDDYKQLENVPARIAIGDVMYKDLDGDGRLTAFGDQTRGLSGDMKYLGNLLPRYTFSSNINLGWKNFDLSIFLQGVGKRNIQYSGAISTPNTFFWPSLAYYHNKTWSPERPDAQYPRYIPGNMGYDDVRNYNYRTSALVMQNVAYLRFKVITLGYDLPRTLAARLRMKSARIYFSGQDLFTISKGTLGNNFDPEDGFRNEGTYPFNKIFAAGLNVKF
>NZ_CP043006.1|WP_148383571.1|1683820_1684975_-|DUF4974-domain-containing-protein
MNAERLKYLLERYRNGQCNEAELAEINEWYHSLNYDPADFNKWLEEESGAKELAGKLYMNFRRTTRREKAGRPLRRIWQAVAVIALLAGMAWSIRTYLLPSKAPADQLAAATITPGKNKAILTLADGSQISLDDASDGQLASQQGTSIIKAANGRLLYGVSANASGIDAPAALNTLYTPRGGQYQITLPDGTTVWLNSDSKLSFPVAFQGKERKVTLTGEAYFEVRHMTSMPFIITTGNQSIEVLGTHFNIAGYEDEQEISTTLLQGSIRVSNMLTKDAEVLVPGQQSQLSRSTGDIKIRQANTEEVMAWKNGYFLFDNEDLAAILRTVSRWYDVEIEFHYTGKHEKFGGTFSRSSDLHNILNNLQELGDVHFKIDQRKIIVTK

Crispr_ID: NZ_CP043006_4

• CRISPR_ID: NZ_CP043006_4
• CRISPR_location: 2118638-2118733
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_4

Consensus_repeat	Method
GGCACCTTCAGGTGTCTTTTTTGTTTTTATG	CRISPRCasFinder

spacers of NZ_CP043006_4

>4.1|2118669|34|NZ_CP043006|CRISPRCasFinder
CTTCCGCGGAAAACGCTGGCGAGCAGCGGAACCT

CRISPR arrays and Neighbor proteins around NZ_CP043006_4

CRISPR arrays

The CRISPR arrays of NZ_CP043006_4

>merge|NZ_CP043006|4|2118638-2118733|CRISPRCasFinder
GGCACCTTCAGGTGTCTTTTTTGTTTTTATGCTTCCGCGGAAAACGCTGGCGAGCAGCGGAACCTGGCACCTTCCGGTGTCTTTTTTGTTTTTATG

>NZ_CP043006|4|3|2118638-2118733|CRISPRCasFinder
GGCACCTTCAGGTGTCTTTTTTGTTTTTATG	CTTCCGCGGAAAACGCTGGCGAGCAGCGGAACCT
GGCACCTTCCGGTGTCTTTTTTGTTTTTATG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148383902.1|2126516_2127293_+|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl|CDD|381169
NZ_CP043006.1|WP_168208737.1|2105895_2106270_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP043006.1|WP_148383884.1|2111208_2112735_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148383890.1|2115725_2117684_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|225814
NZ_CP043006.1|WP_148383880.1|2106524_2109056_+|AAA-domain-containing-protein	unknown	unknown	gnl|CDD|223616
NZ_CP043006.1|WP_148383908.1|2128828_2130484_+|CTP-synthase	unknown	unknown	gnl|CDD|235437
NZ_CP043006.1|WP_148383906.1|2128010_2128541_-|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|239526
NZ_CP043006.1|WP_148383895.1|2120065_2120962_-|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl|CDD|366759
NZ_CP043006.1|WP_148383882.1|2109358_2111116_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148383872.1|2103999_2104839_-|DUF3575-domain-containing-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148383886.1|2112710_2114342_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NZ_CP043006.1|WP_148383891.1|2117699_2118461_+|response-regulator	unknown	unknown	gnl|CDD|225818
NZ_CP043006.1|WP_148383873.1|2104920_2105829_-|ribonuclease-Z	unknown	unknown	gnl|CDD|274246
NZ_CP043006.1|WP_148383893.1|2118806_2120042_-|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl|CDD|237367
NZ_CP043006.1|WP_148383896.1|2121145_2123044_+|30S-ribosomal-protein-S1	unknown	unknown	gnl|CDD|235775
NZ_CP043006.1|WP_148383904.1|2127422_2128007_+|bifunctional-precorrin-2-dehydrogenase/sirohydrochlorin-ferrochelatase	unknown	unknown	gnl|CDD|224562
NZ_CP043006.1|WP_168208739.1|2123852_2124134_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148383888.1|2114440_2115130_+|(d)CMP-kinase	unknown	unknown	gnl|CDD|234579
NZ_CP043006.1|WP_168208738.1|2123221_2123875_-|hexitol-phosphatase-HxpB	unknown	unknown	gnl|CDD|236770
NZ_CP043006.1|WP_148383900.1|2124373_2126488_+|HEPN-domain-containing-protein	unknown	unknown	gnl|CDD|223233

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_168208737.1|2105895_2106270_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.75145e-06
NZ_CP043006.1|WP_148383873.1|2104920_2105829_-|ribonuclease-Z	gnl|CDD|274246	TIGR02651, Ribonuclease_Z, ribonuclease Z. Processing of the 3-prime end of tRNA precursors may be the result of endonuclease or exonuclease activity, and differs in different species. Member of this family are ribonuclease Z, a tRNA 3-prime endonuclease that processes tRNAs to prepare for addition of CCA. In species where all tRNA sequences already have the CCA tail, such as E. coli, the need for such an enzyme is unclear. Protein similar to the E. coli enzyme, matched by TIGRFAMs model TIGR02649, are designated ribonuclease BN. [Transcription, RNA processing].	5.70566e-110
NZ_CP043006.1|WP_148383890.1|2115725_2117684_+|tetratricopeptide-repeat-protein	gnl|CDD|225814	COG3275, LytS, Putative regulator of cell autolysis [Signal transduction mechanisms].	1.00674e-24
NZ_CP043006.1|WP_148383880.1|2106524_2109056_+|AAA-domain-containing-protein	gnl|CDD|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP043006.1|WP_148383908.1|2128828_2130484_+|CTP-synthase	gnl|CDD|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
NZ_CP043006.1|WP_148383906.1|2128010_2128541_-|acyl-CoA-thioesterase	gnl|CDD|239526	cd03442, BFIT_BACH, Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, and brown adipose tissues. The archeal and eukaryotic members of this family have two tandem copies of the conserved hot dog fold, while most bacterial members have only one copy.	1.12334e-50
NZ_CP043006.1|WP_148383895.1|2120065_2120962_-|rhomboid-family-intramembrane-serine-protease	gnl|CDD|366759	pfam01694, Rhomboid, Rhomboid family. This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.	1.4816e-25
NZ_CP043006.1|WP_148383886.1|2112710_2114342_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	1.63752e-07
NZ_CP043006.1|WP_148383891.1|2117699_2118461_+|response-regulator	gnl|CDD|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	3.32716e-37
NZ_CP043006.1|WP_148383893.1|2118806_2120042_-|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl|CDD|237367	PRK13371, PRK13371, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional.	0
NZ_CP043006.1|WP_148383896.1|2121145_2123044_+|30S-ribosomal-protein-S1	gnl|CDD|235775	PRK06299, rpsA, 30S ribosomal protein S1; Reviewed.	0
NZ_CP043006.1|WP_148383904.1|2127422_2128007_+|bifunctional-precorrin-2-dehydrogenase/sirohydrochlorin-ferrochelatase	gnl|CDD|224562	COG1648, CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism].	4.41372e-43
NZ_CP043006.1|WP_148383902.1|2126516_2127293_+|uroporphyrinogen-III-C-methyltransferase	gnl|CDD|381169	cd11642, SUMT, Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT). SUMT is an enzyme of the cobalamin and siroheme biosynthetic pathway. It catalyzes the first of three steps leading to the formation of siroheme from uroporphyrinogen III; it transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yield precorrin-2 via the intermediate formation of precorrin-1. Precorrin-2 is also a precursor for the biosynthesis of vitamin B12, coenzyme F430, siroheme and heme d1. This family includes proteins in which the SUMT domain is fused to other functional domains, such as to a uroporphyrinogen-III synthase domain to form bifunctional uroporphyrinogen-III methylase/uroporphyrinogen-III synthase, or to a dual function dehydrogenase-chelatase domain, as in the case of the multifunctional S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase/dehydrogenase/ferrochelatase CysG, which catalyzes all three steps that transform uroporphyrinogen III into siroheme.	1.71333e-97
NZ_CP043006.1|WP_148383888.1|2114440_2115130_+|(d)CMP-kinase	gnl|CDD|234579	PRK00023, cmk, (d)CMP kinase.	1.18685e-107
NZ_CP043006.1|WP_168208738.1|2123221_2123875_-|hexitol-phosphatase-HxpB	gnl|CDD|236770	PRK10826, PRK10826, hexitol phosphatase HxpB.	1.02857e-94
NZ_CP043006.1|WP_148383900.1|2124373_2126488_+|HEPN-domain-containing-protein	gnl|CDD|223233	COG0155, CysI, Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism].	5.62892e-103

Protein sequences

>NZ_CP043006.1|WP_148383891.1|2117699_2118461_+|response-regulator
MSEIKAIIVDDEQHCIDALKAMLQKKCPEVTVLAGVNSVSDARQIIDELQPDLVFLDVEMPHQNGFELLKQYDKVVFDVIFTTAYEQYALKAIKFNALDYLLKPFSVQDLQEALRKYHERRLNKQDAGITPIEAFLQNMKTMQQTNKKIALPTINGLVFMPVQNIVRCESTGNYTKIFFTDRKQLLVSKPLKEFEELLTDVDFFRIHNSHLINLQQMESYIQGEGGFALMSDGTQVEVSRRRKADFLKKAMQF
>NZ_CP043006.1|WP_148383890.1|2115725_2117684_+|tetratricopeptide-repeat-protein
MSFKGLIFIVILLSGMWMHASAQDSTLVFRTLDSVLSMRDDTVKVNRLMAKSRNFFRYFDRQGLENPFLGEAIAISHKIRYSKGLSEAYNELGTAKRNKSQYILAADYHERALRYAEEIQNDRLMAISLNNMGVDYRRRDMLQKAFEVHFRALKTAEKINDIRNITIAINSIGNIQLSAGKYEDAIEEFTKSLKLEQESNNDLGVAINLGNLGFAYEGLGQLDKAIEYYNNSLAVNQKIGDNKGIAICYTCLGTAYQKKKNYPLAMQYLQKALEANDNNRVADKIHLAESYLAIGRLLNEEGKLEEGRKYVRQSIDLGKSWGFKSILQEAYKAMGENFHRAGMYDSSISSTNISLLYKDSLLDEKSITEFAQMQAMYDVHQKDNQIKLLQQEHDINQLRIRRNLALAIALAGFLFMLIVGGFFYIRHRNLQANRQTLQLELRSLRSQMNPHFIFNSLSSIHRYIWSNNQEEASDYLTKFSKLMRMILDNSQHTFIPLNKELESLRLYLDLEVLRCNNIFDYRIQLADDINDEEVLIPPMIIQPYVENAIWHGLVHRKEKKGRLDIAVSLNGRVLEVTVTDNGIGRKMAMEIKEKKDRTHHSMGMKVTEGRIALIRKINNTKDANVEVRDLEDQVGQAAGTQVRIILPAEFLF
>NZ_CP043006.1|WP_148383888.1|2114440_2115130_+|(d)CMP-kinase
MKKIIITIDGYSSCGKSTLARQLAGRLNYLYIDSGAMYRAITLYFIQQQVDWNKTDAVNNALNNIQLEFIYNQISGQSDMFLNGENVEQMIREMLVAEKVSEVAAIREVREFAVAQQQKMGAGKGIVMDGRDIGTVVFPDAELKIFMTADPAIRVERRFKELYQKNRNITLHEVKENLELRDYIDANREVSPLRKAEDAIVLDNSQLTTEEQLQLVMQWVEDAIMAHSS
>NZ_CP043006.1|WP_148383886.1|2112710_2114342_+|T9SS-type-A-sorting-domain-containing-protein
MVRHQYSIKRDHLKKLFSILLIFFLPLAIYAQQGLYIAPGTRLQVTGNEVVSIFGNVSNNGAFGSSNVAVINFFGKTWNNGNGSTLPDESADGFSGKGGLFRFSGDNPLYGNLGAQQLFGGYSVVTRTGATFPNFEVNNRLGILLSDLSDVKVRNNLHFTTGHIFLNGWNLVVGDRHPGTITGYSEQTFVVTGTNIAGGFLYREQVNAAAGKVVFPVGTSPSAYAPAAVEFGGAADDFKVRAFDSVYQFAISGPANRLDFTNKTWNIAREQNLAGEAKITLQHMDAEEGPDYADYRSSSYLSRYINNAWDYLETPENFPLPGNLTTTNTLRNATMHYRVFAGINSNEYFAKSSVVYGPYAPAVFIDFNAWRVSANFAQLEWYVSRELNNDRFEIERRFDRDTGFTKVGELPSQAPDGNSNIRLDYRYTDANNYEGWTYYRIRAVAKNGRESYSRVKAVPPFLTVDVWPNPNRGQFNVRVRGEQTDMIMQVVNMAGQVMNQYAIRGEANIRVEGLAKGSYLLVFYDRHSSRLMYTRKVIVIDRG
>NZ_CP043006.1|WP_148383884.1|2111208_2112735_+|hypothetical-protein
MNRLNGHFKKAFLLPAYLLCAFSSAAQLKIGGESAAIRGDAALELGTTRKGLLLPRVGNAALSASPLDTAANGMLLFNTGTNSLMVKNGSGAAGWKQVADASALDYLWTMAGNANADDTHFLGTAGMQPLIFKTNLSEAMRIDPAGNIGIGTSYPSSRLHVNGSLATNLVIAATDFSVADSNSVIIMNNAADATLTLQSAAANRGRALEIVSYNLGKIIYAGADVKTQTGAGQTVLLPGYSVRIVSDGTDWVVTSRQRNGLPMYLATAPGTEEGEAPRDYDAFVDKGSGLFLTDGITNPANPIPGETAAFSATWQGTGAASFAQLNVNAGKAYFRSGVNSSVAASVWNRFLSIPAASLFSVADDGADNIVFRHSGNNSISFSTGNTVRATITEAGETRLNHAFSLPIAVAGTSPYTATVDDYTIIVTPSGGTGNFVVTLPAASACKGRIYMVKRFDGAFARPVEVGPASGDRIENGVADASFMLDDENLRCYTFQSDGTDRWYVINIQ
>NZ_CP043006.1|WP_148383882.1|2109358_2111116_+|hypothetical-protein
MRKSLRIASMVLASLLFFSYNSLKAQVKIGGNPAVVDPNALLELESNRKGFLLPRLNNDGFDAIIAANATVGMVVYYTGTNYDGAGLYVKQTTGTTITSWAKLAGADLADGTWKIAGNTGTNPATQFIGTLDNQPVVFRTDAVERFRISATGEFLLDNTGIPVDNAENQVLLLAADGTVKRKTLNLTMVESLSGKTGPVDLKILAGTGFEAEEVDLTVPGEITLNLPVMSGGVATQPYGFMRLEDWEKLNHLTTSGITVGTLVTDESQGASGAKITADGDGGYEIALGEATENVPGVVGTGVQSFAGDKTFTGLTTFSNNVAIDNGVGGDLLVRGKLNIGYPTLYNPVPAPASYNLLVQEGPAATEVKRFNLPSWKLDGGLASVNGVVGAVADGELTLLAGTTGTEPNIVPDALANTVTINIPNAAPANTAGLVTNADQEFAGNKLFGGNVTVSGGNVTVNSATAGNSNLSVNGSIGVKFRRLTTNGNIDVDDYMIFVKPTGSTDVTVTLPDPAGCSGRVYVIKREAKAFPIDELQEDFSVIVATMGGTGKFHGENTTPITVPNTTLNLMSDGTNWQIMSRGSGL
>NZ_CP043006.1|WP_148383880.1|2106524_2109056_+|AAA-domain-containing-protein
MDQNFSPQVKEIISFSREEALRLGNDFIGTEHLLLGIIREGEGTAVKILQALNVDLYELRKEVELAIKDKTGKNIANINSLPLTRQAEKVIRVTVLEAKALKSPTVETEHLMLSILKNKENVCTQILQQFDVDYDTFKNELGFVKSADPKAEFDDPGEEEFEDERKSYASKAKQTNTKSKTPVLDNFGRDITKLAESGSLDPIVGREQEIERVSQILSRRKKNNPILIGEPGVGKTAIVEGLALRIVQRKVSRVLFDKRVVSLDLAALVAGTKYRGQFEERMKAIMNELEKNRDVILFIDEIHTIVGAGGASGSLDASNIFKPALARGELQCIGASTLDEYRMYIEKDGALDRRFQKVMVDPPTVEETIMILNNIKPRYEEYHNVSYADDAIDACVKLSDRYMTDRLLPDKAIDVLDEVGARVHLKNINVPQNILDLEKQIEDIKQEKNKVVKSQRFEEAAALRDTEKKLGEDLEKAKGEWEEEVKHKRYPIDEEAIAEVVSMMTGIPVKRMVQAENEKLRRMGEDLKSAVVGQEEAISKVTKAIQRNRVGLKDPKKPIGTFIFLGPTGVGKTELAKALAKYMFDSEDALIRIDMSEYMEKFSVSRLIGAPPGYVGYEEGGQLTEKVRRKPYSVILLDEIEKAHPDIYNILLQVLDDGILTDGLGRKVDFKNTLIIMTSNIGVRQLKDFGAGVGFTTSARAVNEEDNTKAVIEKALKRTFSPEFLNRIDDVIIFNSLSKEHIYTIIDITMKGVLVRLQNLGFSLELTEEAKGFLAEKGYDQQFGARPLHRAIQKYLEDPLAEEILNMNIHNGDILIADLDKENQKLVFTLKNPSRSKPEKSEA
>NZ_CP043006.1|WP_168208737.1|2105895_2106270_-|STAS-domain-containing-protein
MQFKIDTKEKIVIFRLEETTLDAKMSDELVNAIGNIPGLEEKNLILDLHSLQSADESGLKAIFTVYHRQYERGLSAAIAHLNRTLTTTLSETYPEMQNIVPTESEAIDMVMMEDFERDLDLGSE
>NZ_CP043006.1|WP_148383873.1|2104920_2105829_-|ribonuclease-Z
MFAVTILGNNSAIPTPDRHPTAQVITYNDQLILVDCGEGTQMQLTRYKVRRSRIRHILISHLHGDHYFGLIGLINSLSLLGRTDPLSVYGPPELEEIIQLQLRSAATVLKFDLQFHALLPERTGLLFSEKDMEVHCFPTRHRIPCYGFSFSMQRRKRRLIPEQARVYDIPAAFFSRLQEGADYQRKDGTLVKNDWVTLPPPKGKRYVYCADSIYDEGLIPHIQGADLVYHEATYLHDLAQRAADRYHSTSVQAATLALKAEAKRLLIGHFSSKYTELEPFLEESLPVFPHTELALEGVSYLV
>NZ_CP043006.1|WP_148383872.1|2103999_2104839_-|DUF3575-domain-containing-protein
MKRAALSASVALCFCLGASAQEIPPSTEDPATTAAEAPDRSTGLRNQPYFSNIIKTNLSTLALNNYSLTYERLIARKISASLGWRHMPNTHMTQTALTKEVMKYFEEGDSDINEQLDQLKMSGNALTAEVRFYTGRRPGAKGFYAGVYGRYASFTYDYPYDFESELGTTTRVPFKGKSSGIGGGIILGGQFNVHKRVIIDLYIIGGHYGSFSGKVDGLADLSDLSEQDRTDLKDELESLIEIGDRKNITATVREDGVRADVSMPFLGVRGLGFTVGFAF
>NZ_CP043006.1|WP_148383893.1|2118806_2120042_-|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MKTFNVPVIYRSPLISAIKQYRKQQDRMKKDFTPTLLDFGPIRIQLARHFGFCYGVENAIEIAFRTVEENEGKRIFLLSEMIHNPQVNNDLLSRGVQFLMDTSGKQLIPWESLHADDIVIIPAFGTTLEIEAKLEALGITPLQYNTTCPFVERVWNKAEQIAGKDYTVIVHGKPKHEETRATFSHSRQHTPTVVVKDMAETHRLAAYILGTVPAEQFYEEFKGQYSEGFDVTRHLQRVGVVNQTTMLASETQAIADYIRQAIQQRYQLADDQVSERFADTRDTLCYATNDNQTAVTGMLDAPADLAIVVGGYNSSNTSHLVELCEEKLPTYFISSEEKLLSASELLHWDFHHHQELHSRQFLPEKPENGPVTVLLTSGASCPDAIVESVIRKLLSFYGLEHKAEEAIANFS
>NZ_CP043006.1|WP_148383895.1|2120065_2120962_-|rhomboid-family-intramembrane-serine-protease
MNGTSFKSDIRYWLKQENSVNHLMFVNITVFVVMGILYLLAFLSKGMFGAVYAFLLYQLELHVQPDLLLRKPWTLLTYMFMHAGIFHIFFNMLNLYWFGNMFRTTLGNQRVLPLYILSGLIGALVYLAAYLVFPPTSYLGGPMVGASAAVMCFLVASATLMPDVEIGLLFLGSIKLKWVAVGVIVIDIILIPQGNVGGILAHLGGAAFGYIYVLTLRSGTDLCAPLIALFRTTAGLFDRSKHPPKKFKPKKSPLRVVRKNENLHASRLDELLDKINEKGYDSLSADEKQWLRKYSDEK
>NZ_CP043006.1|WP_148383896.1|2121145_2123044_+|30S-ribosomal-protein-S1
MTENNITNEQNAEQQAPVAETATVETATTNAPVATAHDDFDWSVDKRNVSSYSKEEKEKYDLTYDSTFKAIEENGLLTGIVVGLTNTDVVLNIGFKSDGLISLNEFRDLQGLKVGDEVEVLVVEKEDRDGNLHLSRKQARAQRAWERIVEVYKTGEVVTGTVTSKTKGGLIVDVHGMETFLPGSQIDVKPVTDYDQFVGKTMEFKVVKVNEAIRNAVVSHKALIESDIEQQRVDIISKLEKGQVLEGTIKNITDFGAFIDLGGLDGLLYITDISWGRISHPSEVLQMDQKINVVVLDFDDEKKRISLGYKQLTPHPWDTLPATITEGAKVKGKVVNIEDYGAFLEILPGVEGLVHVSEISWASTPINAKEFFKLGEEYEAVVVTLSKDERKMSLSIKQLTEDPWSTIETKFPLDSRHKGIVKNITPYGVFVELETGIGGMIHISDLSWIKRFNHPSEYTKVGNEIEVVILGIDKDNRKLSLGHKQIEEDPWNTFETIFPIGSIHEGTVVKKDEKGATVQLQYGLEAYAPARHLRTEDEKPIAVEDVKEFQIIEFDRNEKRILVSHTKVWEQVKAEEKDAVIKEKRADAEKTRKTVKNIQSKVEKATLGDLGALAELREKLKQSEGGEEKKGE
>NZ_CP043006.1|WP_168208738.1|2123221_2123875_-|hexitol-phosphatase-HxpB
MINTVIFDMDGLLIDSEPLWGIAMQEVFSSVGVELSSELTHLTTGLRTKEVVSYWHNYFKWNSKTPEQVTAEIIENVTGKILREGQPMEGLQYILDFFRQRNFKMGLASSSPMQLIQSALNHLGIRESFDAVISAEFEPYGKPHPAVYLACARELDSDPLSCLAFEDSVTGMTAAKAARMKVVVVPEAHKRNDKRFGLADMQLGSLLEFNDMLLEKL
>NZ_CP043006.1|WP_168208739.1|2123852_2124134_-|hypothetical-protein
MRNHKTFFTKKEGGKLENIQRKGDLKPKQQDIRVYAVGRQLVTGHIIRLRHQDAMQTALVRWTCRRIPGHSPFLLTFAAQNSKKNNYDQYGDF
>NZ_CP043006.1|WP_148383900.1|2124373_2126488_+|HEPN-domain-containing-protein
MQSFRTELENPIVERDIIELEQKIRLFREGKMPEEKFRSLRLARGVYGQRQQGVQMVRIKLPYGKMTLQQWIRISDISDEYSTGNLHLTTRQDIQIHFVSLDRTPELWAKLEQDDITLREACGNTVRNITGSDAAGIDPNEPFDVTPYADAAFRYFLRNPICQDMGRKFKMSFSSSEKDTAFAFMHDIGVIPKVRVVEGKEIRGFKVMVGGGLGAQPYLAKTAFEFLEEDQLIPYIESVLRVFDRHGERSSRHKARMKFLIQKIGMEEFTRLVQEEYKAIKSKIVPVDHASWQEAAAPAADAQLPAYEVKDQQQYEAWKKTNTFEQKQKGFYAAYVRVPLGNISSVTSRSLVEKLRLVIADDVRITVNQGLLLKYIRPEYLPYVYSVLAEAKLHAPGFDSIADITACPGTDTCNLGISSSTGIAAALENVIHDEFPDLIYNNDIKIKISGCMNSCGQHGMANIGFHGSSLKSAGKVLPALQVLLGGGVLGDGAGRVADKVLKVPSRRGPDVLRTLLHNYESNALPNELFNDYYDRQGEKYFYDLLKPLADLSAVKDGDFIDWGQAETFSTAIGVGECASVIIDLIATLLFEAEEKLEWAAQSFANNAWADGIYHTYACMIQTAKSILLDENVNCNTQHGIINDFDKHFVATGRFQMESFRDLVLQINQHEPTESFAKQYFQQAKAFYDRAQQYRLEKQAAGVNA
>NZ_CP043006.1|WP_148383902.1|2126516_2127293_+|uroporphyrinogen-III-C-methyltransferase
MQVIQPKVTLVGAGPGDPELITVKGLKAIQNARVILYDALSNNELLDHAPQNCLRRFVGKRAGMHVYTQAEINRMIVTYALTYGSVVRLKGGDSFVFGRGQEEVAAAAQYGIETEVIPGISSAISVPGVNNIPVTARNVSEGFWVITGTTQDGKLSRDLEFAIQADTTVVILMGMSKLDEIAAIYSRHGRGQVPAAIIQNGTLPTQKIGVGVAEDLGNIAREQGLRNPAIIVIGEVVRFHEAFQDLQSRLAENYRLAV
>NZ_CP043006.1|WP_148383904.1|2127422_2128007_+|bifunctional-precorrin-2-dehydrogenase/sirohydrochlorin-ferrochelatase
MEQNHLFPVFFKLEQLQMLVVGGGNVGHEKVNAILQNCPAARVTVVATWFAPELEALAAGFPNVTLVQKAFSCGDIFGKDLVIAATADKELNACIWEKAKAGKVLINVADTPALCDFYLGSVVQKGSLKIAISTNGKSPTIAKRLREVLQDAIPETLEAVLNNLGAIRERLKGDFADKVKKLNELTSVLVGKGS
>NZ_CP043006.1|WP_148383906.1|2128010_2128541_-|acyl-CoA-thioesterase
MTLSPKTAHESLINMTELVLPNDTNTFGNLMGGRLMYWMDIAAALACMKHCAAPVVTASVDNISFETPIRLGNVVHIEAKVTRAFTTSIEVHMRVWGEDPVLQYRYKSNEAFMTFVALDPNGKARPVPAIIAESEEEKKLFDGALRRRQLRLILSGKMKPADAGELKALFAGEIDG
>NZ_CP043006.1|WP_148383908.1|2128828_2130484_+|CTP-synthase
MAKYIFVTGGVTSSLGKGIIAASLAKLLQARGFRVTIQKFDPYINVDPGTLNPYEHGECYVTEDGAETDLDLGHYERFLNTPTSQANNVTTGRIYQTVINKEREGAYLGKTVQVIPHITDEIKRRILLLGKDGKYDIIITELGGTVGDIESLPYIEAVRQLQWELGEEDCLVVHLTLIPYLRAAKELKTKPTQHSVRLLSENGVHPDIIVCRTEEPMYRELKKKIALFCNVQVDAVIEANDVGTIYEVPLEMMREKLDVICLKKLNLPIEKEPELVKWREFLDKLKYPKTKVTIGLIGKYVELQDAYKSILESFIHAGAVNECKVIVQNIHSEHITPENVCEKLKNLDGLLVAPGFGHRGIEGKITAIQYARENNLPFFGICLGMQMAVVEYARNVLGLREAHSTEMNPETPYPVISLMEEQKKVTKKGGTMRLGAYTCDLKPGSQASAIYGGASTISERHRHRYEFNNDFLDQMEQGGLTASGKNPETGLVEMIELPTHPFFIGGQFHPELKSTVESPAPIFVSFIHAAKNFAESRNGKTRQAEEKVVHD

Crispr_ID: NZ_CP043006_5

• CRISPR_ID: NZ_CP043006_5
• CRISPR_location: 2151327-2151448
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_5

Consensus_repeat	Method
TCATGTTTCTCATGTTTCGCGTGTGCGGATCAACGTTTATA	CRISPRCasFinder

spacers of NZ_CP043006_5

>5.1|2151368|40|NZ_CP043006|CRISPRCasFinder
AGGATGGATCGTTCTGATGCGGCCATCTGCTTCATGTATC

CRISPR arrays and Neighbor proteins around NZ_CP043006_5

CRISPR arrays

The CRISPR arrays of NZ_CP043006_5

>merge|NZ_CP043006|5|2151327-2151448|CRISPRCasFinder
TCATGTTTCTCATGTTTCGCGTGTGCGGATCAACGTTTATAAGGATGGATCGTTCTGATGCGGCCATCTGCTTCATGTATCTCATGTTTCTCATGTTTCGCGTGTGCGGATCAATGTTTATA

>NZ_CP043006|5|4|2151327-2151448|CRISPRCasFinder
TCATGTTTCTCATGTTTCGCGTGTGCGGATCAACGTTTATA	AGGATGGATCGTTCTGATGCGGCCATCTGCTTCATGTATC
TCATGTTTCTCATGTTTCGCGTGTGCGGATCAATGTTTATA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148383939.1|2154583_2156083_-|MFS-transporter	unknown	unknown	gnl|CDD|225121
NZ_CP043006.1|WP_148383928.1|2145060_2145807_-|glucose-1-dehydrogenase	unknown	unknown	gnl|CDD|235500
NZ_CP043006.1|WP_148383930.1|2145900_2146944_-|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224525
NZ_CP043006.1|WP_148383919.1|2140390_2140786_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148383917.1|2140161_2140401_+|AtpZ/AtpI-family-protein	unknown	unknown	gnl|CDD|378198
NZ_CP043006.1|WP_148383945.1|2160547_2163688_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148383951.1|2167067_2168282_-|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl|CDD|234813
NZ_CP043006.1|WP_148383955.1|2169241_2171224_+|hypothetical-protein	unknown	unknown	gnl|CDD|379481
NZ_CP043006.1|WP_148383923.1|2141463_2141871_-|OsmC-family-protein	unknown	unknown	gnl|CDD|376823
NZ_CP043006.1|WP_148389882.1|2152468_2154568_-|alpha-glucuronidase	unknown	unknown	gnl|CDD|226187
NZ_CP043006.1|WP_148383947.1|2163707_2165489_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
NZ_CP043006.1|WP_148383941.1|2156060_2157227_-|endo-1,4-beta-xylanase	unknown	unknown	gnl|CDD|366032
NZ_CP043006.1|WP_148383931.1|2146970_2148005_-|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224525
NZ_CP043006.1|WP_148383926.1|2143951_2144977_-|DUF4407-domain-containing-protein	unknown	unknown	gnl|CDD|379583
NZ_CP043006.1|WP_148383933.1|2148158_2149328_+|mannonate-dehydratase	unknown	unknown	gnl|CDD|235172
NZ_CP043006.1|WP_148383953.1|2168398_2169211_+|purine-nucleoside-phosphorylase	unknown	unknown	gnl|CDD|350160
NZ_CP043006.1|WP_148383921.1|2140788_2141409_+|SprT-family-zinc-dependent-metalloprotease	unknown	unknown	gnl|CDD|370932
NZ_CP043006.1|WP_148383943.1|2157231_2159799_-|glycosyhydrolase	unknown	unknown	gnl|CDD|379757
NZ_CP043006.1|WP_148383924.1|2141961_2143884_-|mucoidy-inhibitor-MuiA-family-protein	unknown	unknown	gnl|CDD|274045
NZ_CP043006.1|WP_148383949.1|2165605_2166934_+|xylose-isomerase	unknown	unknown	gnl|CDD|235487

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148383939.1|2154583_2156083_-|MFS-transporter	gnl|CDD|225121	COG2211, MelB, Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism].	9.1043e-118
NZ_CP043006.1|WP_148383928.1|2145060_2145807_-|glucose-1-dehydrogenase	gnl|CDD|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	9.35419e-79
NZ_CP043006.1|WP_148383930.1|2145900_2146944_-|substrate-binding-domain-containing-protein	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.24394e-103
NZ_CP043006.1|WP_148383917.1|2140161_2140401_+|AtpZ/AtpI-family-protein	gnl|CDD|378198	pfam09527, ATPase_gene1, Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter. This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme. It carries two transmembrane helices and is a magnesium or calcium uniporter. The atp operon of alkaliphilic Bacillus pseudofirmus OF4, as in most prokaryotes, contains the eight structural genes for the F-ATPase (ATP synthase), which are preceded by an atpI gene that encodes a membrane protein with 2 TMSs. A tenth gene, atpZ, has been found in this operon, which is upstream of and overlapping with atpI.	2.52515e-06
NZ_CP043006.1|WP_148383945.1|2160547_2163688_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_148383951.1|2167067_2168282_-|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl|CDD|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0
NZ_CP043006.1|WP_148383955.1|2169241_2171224_+|hypothetical-protein	gnl|CDD|379481	pfam14121, Porin_10, Putative porin. This family of membrane bet-barrel proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 655 and 722 amino acids in length. SRI_1264 is identified by Gene3D as a membrane bound beta-barrel. These sequences are putative porins.	9.81896e-86
NZ_CP043006.1|WP_148383923.1|2141463_2141871_-|OsmC-family-protein	gnl|CDD|376823	pfam02566, OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation.	2.18909e-11
NZ_CP043006.1|WP_148389882.1|2152468_2154568_-|alpha-glucuronidase	gnl|CDD|226187	COG3661, AguA, Alpha-glucuronidase [Carbohydrate transport and metabolism].	0
NZ_CP043006.1|WP_148383947.1|2163707_2165489_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	2.21589e-30
NZ_CP043006.1|WP_148383941.1|2156060_2157227_-|endo-1,4-beta-xylanase	gnl|CDD|366032	pfam00331, Glyco_hydro_10, Glycosyl hydrolase family 10.	7.12387e-117
NZ_CP043006.1|WP_148383931.1|2146970_2148005_-|substrate-binding-domain-containing-protein	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	5.06322e-100
NZ_CP043006.1|WP_148383926.1|2143951_2144977_-|DUF4407-domain-containing-protein	gnl|CDD|379583	pfam14362, DUF4407, Domain of unknown function (DUF4407). This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.	2.9453e-95
NZ_CP043006.1|WP_148383933.1|2148158_2149328_+|mannonate-dehydratase	gnl|CDD|235172	PRK03906, PRK03906, mannonate dehydratase; Provisional.	0
NZ_CP043006.1|WP_148383953.1|2168398_2169211_+|purine-nucleoside-phosphorylase	gnl|CDD|350160	cd09009, PNP-EcPNPII_like, purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA). Human PNP catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. Patients with PNP deficiency typically present with severe immunodeficiency, neurological dysfunction, and autoimmunity. Escherichia coli PNPII, product of the xapA/pndA gene, catalyzes the phosphorolysis of xanthosine, inosine and guanosine with equal efficiency and has been referred to as xanthosine phosphorylase and inosine-guanosine phosphorylase. E. coli PNPII is also capable of converting nicotinamide to nicotinamide riboside, and may be involved in the NAD+ salvage pathway. It is one of two purine nucleoside phosphorylases found in E. coli, which also contains PNPI, which displays a different substrate specificity and belongs to a different subgroup of the nucleoside phosphorylase-I (NP-I) family than PNPII. NP-I family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	3.72084e-157
NZ_CP043006.1|WP_148383921.1|2140788_2141409_+|SprT-family-zinc-dependent-metalloprotease	gnl|CDD|370932	pfam10263, SprT-like, SprT-like family. This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteristic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.	3.87188e-06
NZ_CP043006.1|WP_148383943.1|2157231_2159799_-|glycosyhydrolase	gnl|CDD|379757	pfam15979, Glyco_hydro_115, Glycosyl hydrolase family 115. Glyco_hydro_115 is a family of glycoside hydrolases likely to have the activity of xylan a-1,2-glucuronidase, EC:3.2.1.131, or a-(4-O-methyl)-glucuronidase EC:3.2.1.-.	0
NZ_CP043006.1|WP_148383924.1|2141961_2143884_-|mucoidy-inhibitor-MuiA-family-protein	gnl|CDD|274045	TIGR02231, Hypothetical_protein_ZK1055.6b, conserved hypothetical protein. This family consists of proteins over 500 amino acids long in Caenorhabditis elegans and several bacteria (Pseudomonas aeruginosa, Nostoc sp. PCC 7120, Leptospira interrogans, etc.). The function is unknown.	3.42118e-48
NZ_CP043006.1|WP_148383949.1|2165605_2166934_+|xylose-isomerase	gnl|CDD|235487	PRK05474, PRK05474, xylose isomerase; Provisional.	0

Protein sequences

>NZ_CP043006.1|WP_148383933.1|2148158_2149328_+|mannonate-dehydratase
MHQTMRWFGPNDPVTLADIRQAGCSGVVTALHQVPVGEIWTVEDINRRRALIEAAGMRWTVIESLPVSDDIKRRSGRYRQHIAHYRQSLRNVAACGLKVVTYNFMPVLDWLRTDVDYRMPDGSKALYFERLAFVAFDLFLLERPGASAAYSHEEAAAARLYFDGLTTEGRERLFRNVLLGLPGSDEAFTPAQVLAALKSYEGIDAGRLRDNLFLFLQEVVPVAEACGLSMAIHPDDPPYPVLGLPRIVSTEEDIAAIIHAVPSPANGLCYCTGSLGARADNDVLRILRRFGDQIHFLHLRNTKRDENGNFFEAPHLEGDTDMYAVVKEIVQLQRRRNTAIPMRPDHGHQMLDDLRKRTYPGYSAIGRLKGLAELRGLETGIRRWMDEAG
>NZ_CP043006.1|WP_148383931.1|2146970_2148005_-|substrate-binding-domain-containing-protein
MENGKEVTIYDIAKRLSISAATVSRGLQDHPAVSKKTKRKINDMAYEMGYRTNQFARNLRQQQTKTIGVLVHELKSSFITSVLAGIEKITATAGYDIVIAHSSESAQKEAANARNLFNKRVDGLIASLSFDTTDLDHFQPFADKGVPVIFFDRVEQTGQNTVVVIDNAKCGYIATSHLIEQGCKRIAHITSSLRRNVYALRHKGYQDALADNNIPFDESLVVISALSEQAAVDATTQILSMKPLPDGIFVTNDFVAAVCIRTLKEQGIRIPEDIAIVGFNNDAIGTLIEPALTTIDYPGMDMGEIAARNMIDHLKGVSPIHHTSTIVVRSQLIVRESSLKKQYP
>NZ_CP043006.1|WP_148383930.1|2145900_2146944_-|substrate-binding-domain-containing-protein
MLKKEGKEITIYDIATKLKLSPSTVSRALQDHPSISKKTKKRIFELAAEVGYRQNHFARNLRSDKTLVLGVIVPRLNSNFMSSAIAGMEMIANEHGYSLLISQSSESAIKEAASAKTMFNSRVDGLLVSLAFDTESLEHFDSFFKRNTPVFFFDRTMPHDSSTNILIDNYRAGYNVTRHLIEQGCKKIVHITAPPRQNVYRDRLAGYKGALADAGIAFEEGNVIITDLTQDAGYQTAQKIAGWEQRPDAVFVANDSCAIGCMLALKEKGIRIPEDIAFAGFNNDPVSTVIEPNLTTIGYSGYEMGQVAARHMINHLKGTFPIDPTNTIILRSELIVRASSVKHKPGS
>NZ_CP043006.1|WP_148383928.1|2145060_2145807_-|glucose-1-dehydrogenase
MHKQKIAIVTGGGSGIGLAIAEKFIREDIHTIIVGRDAGKLGAAAEKLGALCQAITFDLNNFAEIPALVSRIIDQHGKIDILVNNAGINMKKAFTEVTDGDFQSILQTNVTAVFVLSREVVKSMLQNGVKGSIINISSMASRYGIPKVIAYTAAKSAIEGMTRAMATELSPEGIRINCIAPGFIATDMSAKALDSDPERKAKALGRTPMGALGQPSDIGDAAAFLASDAAKYITGVVLPVDGGNAIGF
>NZ_CP043006.1|WP_148383926.1|2143951_2144977_-|DUF4407-domain-containing-protein
MLRIRQFFLICSGAHLPMLRRAPAEMNKYAGIGATIFFTGLLAALSGGYALWTVFQEPWAAVLFAIVWGLMIFNLDRYIVSSMRKRDRFGQELWIALPRVVLAVLIAIVISKPLELRVFDKEIRAELVIMEQQKFRAQEEKVGERYAARSQEIKSRLQILQEEIRLQAARRDTLMLLAQQEADGTGGSRIRNLGPIYKAKKADADSAGVALEALQQRYALLNRELAQVDSSVTSGINQLERGSLDGFASRLDALGTLTRNSTPIRWANWFIMLLFIAIETAPVFVKLISPRGPYDDLLEQHEYSFTMFRKERKAMLGMDTEERIAKRKAESEQSVKQTAFT
>NZ_CP043006.1|WP_148383924.1|2141961_2143884_-|mucoidy-inhibitor-MuiA-family-protein
MKTYLTLLLAVLSFHGNAQTKKQTVLSKIDKVTVFMQGAQVMRSANTAIPAGTTTLVFPQISPELEEKSIQVQGQGAFTILSVSRERNYLRGQAPDEEIEKLKQQQTVLEEKVAREKARQKVFAQEEAMLTKNQDLRGTNTGLKTQDLREALDFQRARLSEILEQQISIDKHITQLNNGISRLLAQQKVLMAVKDSSTSDLLITVLSKENINGKLTLSYMVKNAGWYPSYDLRVESISQPMDLAYKANVFQQCGEEWKNVKLSLSSGNPSESGLKPELQPWLMRTFYSRQEMMAAQMRQSSMGRNEVRGRIYDENNNPLPNVSITIPGRTIGTISRENGEFSLQLPPDAQTLKVNYIGYEPQEVRLTGNDINIRLQPAAQALEEVVVMGYGVQKKADMTGSLQGNVSGVRIRGTASAPAPPKLKQQSEVPLEVNTTFHSTSVHFDIATAYTIPSDGKPYTVNIMEKEVPAHYEYHSAPKIDLSAYLLAGITDWEQLNLLEGETSIYFEGTYLGKSLLNLQTASDTLFVSLGKDKGIVINRSLQKGFSKSQYLGSNHIVARNWEISVRNNKREPVRVFLEDQLPISVQREVEISKTEYPGAVLDEATQKVTWDLNIAAREEKKTNLQYVVKYPKGRVINLD
>NZ_CP043006.1|WP_148383923.1|2141463_2141871_-|OsmC-family-protein
MQIHIKTIHDSSAAAGWAGPRSLVIDRTPRTGGLGIGFSGEELFMMSIGASICNDLFREAANLELEISDVEIIINGDWSGEPAHARNIRYDVKVHSSAPREKIEEMVRFIDQVAEIPHSLRVGTPVKLNTINIVQ
>NZ_CP043006.1|WP_148383921.1|2140788_2141409_+|SprT-family-zinc-dependent-metalloprotease
MKQEAPLQALAGYLPEGTFEQVIAYITQFKVHLTITRERQSVLGDYRHPYENKGHRISINGGLNKYAFLLTLLHEIAHLVTFIKYGHRVSAHGKEWKQEYGLILKEFVGKQYMPHDVEAAVRESLHNPAASSCADEALMRVLKQYDRRKENHYLVEQLPAGQLFRTKDGRVFRKGERVRKRFRCEEVPSGKVYLFSPVYEVELVSE
>NZ_CP043006.1|WP_148383919.1|2140390_2140786_+|hypothetical-protein
MTDKFILWLAVVSGLITAALFFLKGWLQQALGVHFEVLVAGNIALALITFISYSLNRKGMKADNPNVFVRSVYASTLAKLMLCATGIVVYVMVNRSTVSKATIFLLMFFYLVYTVFETMHLYRTSIKQKKY
>NZ_CP043006.1|WP_148383917.1|2140161_2140401_+|AtpZ/AtpI-family-protein
MLIPVMTDPSSRKKPYNSLWKYAGLAFQMLAAIGLSLWLGHLLDQWTGMRFPLFMIILSLLALALLLWQIVKDTSKHDR
>NZ_CP043006.1|WP_148389882.1|2152468_2154568_-|alpha-glucuronidase
MPGIKIACTYCLFLLLGFAVKADDGHALWLRKRPANPVNVVSAKQSPILEIARKELQDGWLGSAGATFVLTIKKDRSIRGDGYRFDGSGVQANTELGILYGVYEVLRRQQTGLPVMPTVSNPSYDRRILNHWDNLNGSVERGYAGLSIFWRDEKDAPAVTEKDRSLWLEYARANASLGVNGTVINNVNASPRVLTRPYLEKVKAVADIMRRYGIRTYLSVNFSSPAQLGGLKNSDPLVPEVAQWWKDKTKEIYALIPDFGGFLVKANSEGQPGPQDFGRTHADGANMLADVLKPYGGIVMWRAFVYAPNDNDRAGQAYTEFVPLDGQFRDNVIIQVKNGPIDFQPREPFSALFGAMKKTSVMPELQITQEYLGHSNHLAFLAPMWEECLQSDTYQQGAGSTVARCSDGSIYPQRYTAIAGVANTGLDTNWCGHTFAQANWYAFGRLAWNNQLGSEKIAEEWLQLTFGPEDAAGPAPAKEEWQQQFFLPVKQMMLESREAVVNYMMPLGLHHIFSVFEHYGPGPWYGPKGVRPDWTPPYYHQADTNGIGFNRTATGSNTLSQYKEPLHTQLANPATCPEELLLWFHHLPWDYRVKSGRSLWDELCYSYQKGLLQVRGFQQTWDKVEPYADAARFRKVQSKLRRQCLDAQIWKDACLLYFQQFSRRPIPFDIERPVYDLDYLMKLNPLTLQVFERNARQHH
>NZ_CP043006.1|WP_148383939.1|2154583_2156083_-|MFS-transporter
MASPQTPEKQTPTHHLSVLEKVGYSLGDLAANLIFQTLMAFLAFFYTDIYRIPPAKASLVMLTGGFAGALFNLVMGAVADRTQTRWGKFRPWILWTAIPFGAISLLAFSTPDFNEGGKVAYAFVTYFLLVIIYSANNLPYSALSGVMTGDMKERNSLSSYRFVAVMLAQFIIQVFLLPLAISVGDGDKAAGFEKVMLVFAVTGVICFLITFLTTRERVTPPKEQRTPLKEDIGDLLKNKPWLIMLTLTVLVFITLAIKGGMNIYYFRYYLNEASQSSFLQSLGFSHLLDNLSSTFGPEAFEEFRNPDSAPYAAASITSAASTIAMIIGILFSKSLADKFGKRNIFGIFLALSALCLIAINFLSDTAVAAVFIIQTLHGLVYGVTIPLLWAMIADVADYSEWRNNRRATAIIFSAMIFGLKVGLSLGGALSAWLLGLFGYDAEATRQTAAAVKGIRLLVSVIPGTLFIAGAALLSAYSIGKESELQIEKALKERRKESFS
>NZ_CP043006.1|WP_148383941.1|2156060_2157227_-|endo-1,4-beta-xylanase
MLHRSTTVITICALGLLLTAGAGSDNSPALQDYPSLKEVFRDDFTIGTALSARQIEEKDPGAAALVPQQFNMITPENIMKAVIIHPEWGKYNFGPADKLVEYGKKHNIGINGHTLIWHSQLPPFVRHIQRADSFRMFFSEHINTIARRYHGKVFSWDVVNEALNEDGSLRKSVFLDKMGEDYITEAFRLTAAASPGTELYYNDYNNEQPAKRAGCITLVKKVQAAGVRIDGVGIQGHWHLGKVPLKDIEESIIQYAALGLKVMITELDIEVLPRNFQGADVSQRIQASPALNPYPNGLPDSVQQQLADDYEALFRLFLKHRDKVTRVTFWGVNDGQSWLNGWPVRGRTNYPLLFDRAFQPKPAFYKVIATKKHPVTAKKSPNGESPNP
>NZ_CP043006.1|WP_148383943.1|2157231_2159799_-|glycosyhydrolase
MKKLLTALVCLSLFLRLHGQTIIETKATAHSFTLGNAHICVAAGDDELVRLAAGFLQKDLAAVTGRTPGLSDAIPAKANTVIIIGSLERSPLIRSLIKENKLDASTIKGKWEAYTIRTISNPFSSIAQAIVIAGSDRRGTAYGIFELSRQLGVSPWYWWADVPVKKKDVVHIRKNASVSDTPRVKYRGIFINDEAPALSGWSREKFGGFNHTFYEKVFELILRLKGNYIWPAMWGNAFYDDDSLNINTADRFGIVIGTSHHEPLMRAHDEWRRYGSGLWNYDSNAVRLQEFWRAGLQRAWNEKIVTIGMRGDGDKPMSRETATALLERIVKDQRNIISATTGKPAAETPQLWALYKEVQDYYDKGMSVPDDVTLLLCDDNWGNIRRLPDPHAAPRKGGYGIYYHFDYVGGPRNYKWLNTNPLPRIWEQLHLAYRYNARQIWIVNVGDIKPMEFPISFFLDYAWDPERINADDLQSYTEQWAAEQFGQPHAAAIAELVAGYGKYNSRRKPELLDAGTYSFNYNEWDNVVEDYNTLLKKAEQLNTALAPEYRDAFFQLVLHPVKACANLNEMYYHAALNHRAYAQKQQAANMHADKVQELYRNDSLITLAYHQLNNGKWNHMMSQAHIGYTYWQQPPQQKMPAVKYLSADAVIATPPEEKHPAKKAPVPANVNGNVFYEDEWRGVSIAADHFTSAVNTNGISWQVLPDHGRTGSAITPFPVTAAAQNPGGKAPHVVYEFYTYSEGPCTLSAYCSPTLNFTGAEEGLQYAVSIDDETPQIISINKEDKATGSGIWNKWVAENIIIKTSKHYIAKPGKHHIRYWMVDPGVVLQQLVLDFGHVKQSYLGPPETIHHHNKK
>NZ_CP043006.1|WP_148383945.1|2160547_2163688_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKQIVNFSKQLLRLALPALFLLVAERGSAQNITVKGRVLKIDGLPAQGVTVQIKGTTRGTVTNAEGEYSLSAPPGGTLVFSAVDFERQEVRIDSRALVDVRLVPVERMLEGVVVVGYGTQKKRDVTGATVSVKGETLREVGAPNVFNQLQGRAAGVDIVSNGSSIGTGGEIRIRGNRSLATSASNNNAQNGPLVVVDGIALSGGSINDINPADIESMDILKDASATAIYGSRGSGGVIIITTKRGRTGKPVTSYDGYVGISEAIGTYRLFNGQEYAAFKQAAREGQPDPNSPHPNALTQVETDNLANGVSTDWQDLLLTRGIRTDHNLNISGGSENTQYSFGFGYFRETGIIHDQSFDRGSLRFAIDHKMSKRLKVGITSSNIMSYGNRIGTNAYGAATRLSPLYLPYNADGSINFQPAIQQSNDATQISPLTSIGNNDKIKALTRRFRTLSSVYGELGIIDNLKFRTSFSFDWIQTRGSNYTGAGTVFNANTTTAGANLSQNNEETWQYTINNTLTYDKTFGDKHRIQATALHEVIENYFHGQAFDGQGVPADYIQDYNFQLVNTVNAQASGYSKRGLLSYMGRVFYSYDNRYMITATVRRDGASVLAPGNQWFTYPAVSVGWSLSDERFMENVKFVDNLKLRAGWGISSNQTIAPYTTIGSLSSNFYNYGQGTTPNVNYVAGYIINSLPNPALTWESTRGYNLGLDFALFSNRLSGAVEYYNVKTGDILLNKELPRSNGANFVLVNQGQTGGHGFEISLSSINVKSNSGFSWSTDANLFLSREKILALQPGLMQDVGNGWYVGQPLTVIYDVKKTGIWQTGEATEAAVYGAAPGDIKIEDVNKSGSIDAADRQVIGDFQPDFVAGLTNSFQYKNFDLSFTMFGRFGQTVVVTYLTADGGANGYPFFMNSRVNQFKVNYWTPDNPTNEFPQPDASRDALQYTSTLSYRDGSFIKLRTINLGYNLPSTLLNRFGVNSLRIYLSAQNPFIVWAPLVRDGLGIDPEGNGNGNAVGSTAGGTPVVGRAVTVNMGVPPSRQFIFGANLKF
>NZ_CP043006.1|WP_148383947.1|2163707_2165489_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKRSILLSLTLALAILAAAPGCNKVLNEQPRASIDPAFFRTPEGLEGGIAGIYSSLRGHWSTQIFSQLFNGGTDEMVRGGAADVQHYFTYSPLMASNTNDYSGFWNSLYIDINTANGILQYGADAQMDAARKAQLLAQAKFLRAFCYYFLVTTFGDVPLHLEFNTSPTSADARAPIADVYAAIIKDLTEAAAELPDQPGTGLGKPAYKATALFLLAKTYLWRGWSAAAQASDFNNAFDISKELIDNKAVYGLDLWPAFIDGFLEGNEYGMETIMVVDHTKDLKFGQNSAPGSFASNLSENKSNFMFRPNYPTVNANYPASGGASVCVRDIQNGRPFLRIRPNMRYLLDVAFANRATDSRYDGTFQTVWLSNSTQMAPAGTPGAVTPRGTLINKVDTAIWCADRVVSPAERAAFKGIILEPEHLPGATVPFTGTMFPSLRKWDDSTRADLNDYSDRPYILFRFAEVYLIAAEAAFKGGATMQDAADMLNVLRIRAARKPDQTPAEYAAAVAAQTITPAQVTLDFILDERTRELYGEAVRWWDLARTRTLVPRLQQYNLEGGPNVKDFHMLRPIPQQQIDLVTEGPPFPQNDGYF
>NZ_CP043006.1|WP_148383949.1|2165605_2166934_+|xylose-isomerase
MTTIAAKKEFFKGMPAIRYEGRDTDNPLAFRWYDENRIVSGKSMKDHLRFACAYWHSFNGSGADPFGEPTHLFPWNEKQDLLQRAKDKADAAFEFITKLGMPYYCFHDVDVVDHTGTIAENERHLQVMVDYLQEKQAESGVKLLWGTANLFSHRRYMNGAATNPDFLVLAHGAAQVKAALDATISLGGENYVFWGGREGYMSLLNTDMKREKEHLATFLHTAKDYARKQGFSGKFFIEPKPCEPTKHQYDYDSETVIGFLRQYDLLQDFSLNIEVNHATLAGHTFAHELQVAADAGLLGSIDANRGDYQNGWDTDQFPNNVGELTEAMLIVLQAGGFKGGGINFDAKVRRNSTDPADLFHAHIGGMDVFARALLAADAMLQDTAYNAFRRERYASFDKGEGKAFEEGKLSLEELRAFAVEKGEPAMKSGRQEWLENIVNRYS
>NZ_CP043006.1|WP_148383951.1|2167067_2168282_-|ADP-forming-succinate--CoA-ligase-subunit-beta
MNLHEYQAKELLKKYNVPVQEGIPVDTPEAAAEAYKQLKVQFGNEFAVVKAQIHAGGRGKGKVNGTEQRGVQVGKNSEDVKTIAGNILGGTLVTIQTGPAGKVVNKVLVAQDVYYPGPNPVKELYLSILLDRAKGQNVIMYSTEGGMDIEEVAHNTPDKIFKELVHPGGPLQAFQARKIAFNFGLKGEAFKNMVKFVTNLYNAYVGLDAAMLEINPLFKTSDEKIIAVDCKMNLDDNALLRHPDLVALRDVTEEDPTEVEAGKHNLNFVKLDGNVGCMVNGAGLAMATMDMIKLSGGEPANFLDVGGTANAQTVEAGFRIILKDPKVKAILINIFGGIVRCDRVAQGVIDAYNSIGTIKVPIIVRLQGTNAEEAKKLIEESGLKVQSAILLSEAATLVNKAVSA
>NZ_CP043006.1|WP_148383953.1|2168398_2169211_+|purine-nucleoside-phosphorylase
MLTQINEATAYIQQFVKAQPQAGIILGSGLGNLADGITDKTEISYNDIPHFPPATVEGHSGRLILGKLAGRPVVAMAGRFHYYEGLSMQQVTFPVRVMKALGIHTLLISNAAGGMNSQFRVGDLMIITDHINLQPEHPLRGKNIEALGPRFPDMSEPYAKTLIASAKSIAAAKNIPLHTGVYVGVQGPTFETRAEYKFMHIIGGDAVGMSTVPEVIVAVHSGLKVFAMSVITDLGIREEENVITHEEVLAAANAAAPHLTYIFSELVRQL
>NZ_CP043006.1|WP_148383955.1|2169241_2171224_+|hypothetical-protein
MRQFIIFFLLLVCTGTALRAQFNTNRLPVGGGGNASMQRDTTKHEHEPDTLTLRFRYLDEPTDFMLDSSLYDFNLNYLRVPASYTTLGNNGTAARNLIFTPRMQAGFDPGFHAFDIYGYNHQNARFYNTNRPYSELGYLIGGQQEQMINLMHTQNRGQKFNFSFDYRKVNSPGFYLNQSTNHDTYRVTANYNSQNKRYHVLASYYLNKFNGGENGGIRADSFLHKPEYDQLRLIPTKLGGEGTAGNSFFNTFIPVKNAYQEASFMLRHQYDWGRGDTVHVNDTTQYYKFDPFFRVEHTFTYTQNTYRYMDTDPDSAYYQPRYGFSILPVAEGRDSVLSRHQWRILSNDLSLMQFPVRGNMAHFIRVGAGIDNIIGEFMRSSVTFQNLSIHGEYRNKTKNGKWDLQAKGEFYLLGENAGDYMATGTLSRYINDLLGNVSLMAKNVNKEPSYVYRYFELNHDQIYRNPDIGKENITQLQFRANNRRLKYDLQANYYLFNKYTYFRSFNESDQFTGLFNLLQIVFHKRFNIRSFTWDADLAFQQLAGSAPINMPTVWTRQRFAYNGQLYKNLNLYTGIEAKYNTPYYADDYSPVMGQYFYQDTLQFSNVPDIAAFVHFRIKSFTAYVRAENLNIFVFDRNFYAPSYPANNFALRVGLRWWFVN

Crispr_ID: NZ_CP043006_6

• CRISPR_ID: NZ_CP043006_6
• CRISPR_location: 2905917-2906140
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP043006_6

Consensus_repeat	Method
GCCGGAATGTCTCGTGCGCTGCCTGTTTTTATTCAAGCCATCCACCCACAT	PILER-CR

spacers of NZ_CP043006_6

>6.1|2905968|62|NZ_CP043006|PILER-CR
CAAAACCATACACTTTATATCTTGTAAGACCTGCCCATGAGTGGCAAGCCTGATGTTCGCCA
>6.2|2906081|42|NZ_CP043006|PILER-CR
CAGATAAGACCCACCCATGATTGGCAAATCTGATGTTCGCCA

CRISPR arrays and Neighbor proteins around NZ_CP043006_6

CRISPR arrays

The CRISPR arrays of NZ_CP043006_6

>merge|NZ_CP043006|6|2905917-2906140|PILER-CR
CGCTGCCTGTTTGTATTCCAAAACCATACACTTTATATCTTGTAAGACCTGCCCATGAGTGGCAAGCCTGATGTTCGCCAGCCGGAATGTCTCGTGCGCTGCCTGTTTTTATTCAAGCCATCCACCCACATCAGATAAGACCCACCCATGATTGGCAAATCTGATGTTCGCCAGCCGGAATTTCTCGTGCGCTGCCTGTTTTTATTCAAGCCATCCACCCACAT

>NZ_CP043006|6|1|2905917-2906140|PILER-CR
CGCTGCCTGTTTGTATTCCAAAACCATACACTTTATATCTTGTAAGACCTG	CCCATGAGTGGCAAGCCTGATGTTCGCCAGCCGGAATGTCTCGTGCGCTGCCTGTTTTTATT
CAAGCCATCCACCCACATCAGATAAGACCCACCCATGATTGGCAAATCTGA	TGTTCGCCAGCCGGAATTTCTCGTGCGCTGCCTGTTTTTATT
CAAGCCATCCACCCACAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148385159.1|2905142_2905352_-|addiction-module-toxin,-HicA-family	unknown	unknown	gnl|CDD|377942
NZ_CP043006.1|WP_148385150.1|2900883_2901741_+|DUF4843-domain-containing-protein	unknown	unknown	gnl|CDD|374383
NZ_CP043006.1|WP_148385175.1|2913343_2914150_-|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl|CDD|234651
NZ_CP043006.1|WP_148385144.1|2893764_2894907_-|DUF4974-domain-containing-protein	unknown	unknown	gnl|CDD|226235
NZ_CP043006.1|WP_148385162.1|2906885_2908217_+|DUF2130-domain-containing-protein	unknown	unknown	gnl|CDD|370744
NZ_CP043006.1|WP_148385171.1|2911636_2912815_-|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173840
NZ_CP043006.1|WP_148385152.1|2901838_2903395_+|hypothetical-protein	unknown	unknown	gnl|CDD|374525
NZ_CP043006.1|WP_168208786.1|2910616_2911594_-|FAD:protein-FMN-transferase	unknown	unknown	gnl|CDD|224394
NZ_CP043006.1|WP_148385167.1|2909929_2910553_+|outer-membrane-beta-barrel-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148385146.1|2894950_2895505_-|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl|CDD|274376
NZ_CP043006.1|WP_168208785.1|2909264_2909903_+|DUF4136-domain-containing-protein	unknown	unknown	gnl|CDD|379281
NZ_CP043006.1|WP_148385177.1|2914267_2915137_+|TIM-barrel-protein	unknown	unknown	gnl|CDD|224007
NZ_CP043006.1|WP_148385155.1|2903425_2904580_+|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|239264
NZ_CP043006.1|WP_148389909.1|2895935_2899280_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148385180.1|2915186_2916554_+|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP043006.1|WP_148389910.1|2908273_2908894_+|HAD-IA-family-hydrolase	unknown	unknown	gnl|CDD|319790
NZ_CP043006.1|WP_148385148.1|2899390_2900857_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|185760
NZ_CP043006.1|WP_148385141.1|2892931_2893669_+|response-regulator	unknown	unknown	gnl|CDD|225818
NZ_CP043006.1|WP_148385157.1|2904740_2905127_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197775
NZ_CP043006.1|WP_148385173.1|2912908_2913334_+|hypothetical-protein	unknown	unknown	gnl|CDD|367663

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148385159.1|2905142_2905352_-|addiction-module-toxin,-HicA-family	gnl|CDD|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	1.69807e-13
NZ_CP043006.1|WP_148385150.1|2900883_2901741_+|DUF4843-domain-containing-protein	gnl|CDD|374383	pfam16132, DUF4843, Domain of unknown function (DUF4843). This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various Bacteroides species. Distant homology analysis suggest distant relation between this family and other families of proteins with immunoglobulin-like folds, which are often involved in substrate binding. However, specific function of this family is unknown. There is distant homology to the Calx-beta family pfam03160.	4.46011e-25
NZ_CP043006.1|WP_148385175.1|2913343_2914150_-|orotidine-5'-phosphate-decarboxylase	gnl|CDD|234651	PRK00125, pyrF, orotidine 5'-phosphate decarboxylase; Reviewed.	2.48259e-85
NZ_CP043006.1|WP_148385144.1|2893764_2894907_-|DUF4974-domain-containing-protein	gnl|CDD|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	6.88167e-24
NZ_CP043006.1|WP_148385162.1|2906885_2908217_+|DUF2130-domain-containing-protein	gnl|CDD|370744	pfam09903, DUF2130, Uncharacterized protein conserved in bacteria (DUF2130). This domain, found in various hypothetical prokaryotic proteins, has no known function.	7.38574e-69
NZ_CP043006.1|WP_148385171.1|2911636_2912815_-|acyl-CoA-dehydrogenase	gnl|CDD|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
NZ_CP043006.1|WP_148385152.1|2901838_2903395_+|hypothetical-protein	gnl|CDD|374525	pfam16407, PKD_2, PKD-like family. This is a PKD-like family of proteins found in various Bacteroides species.	3.02033e-22
NZ_CP043006.1|WP_168208786.1|2910616_2911594_-|FAD:protein-FMN-transferase	gnl|CDD|224394	COG1477, ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism].	1.01508e-88
NZ_CP043006.1|WP_148385146.1|2894950_2895505_-|RNA-polymerase-sigma-70-factor	gnl|CDD|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	1.72332e-35
NZ_CP043006.1|WP_168208785.1|2909264_2909903_+|DUF4136-domain-containing-protein	gnl|CDD|379281	pfam13590, DUF4136, Domain of unknown function (DUF4136). This domain is found in bacterial lipoproteins. The function is not known.	1.32721e-24
NZ_CP043006.1|WP_148385177.1|2914267_2915137_+|TIM-barrel-protein	gnl|CDD|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	3.0028e-24
NZ_CP043006.1|WP_148385155.1|2903425_2904580_+|redoxin-domain-containing-protein	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	2.32312e-36
NZ_CP043006.1|WP_148389909.1|2895935_2899280_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	3.54651e-152
NZ_CP043006.1|WP_148385180.1|2915186_2916554_+|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	3.56064e-31
NZ_CP043006.1|WP_148389910.1|2908273_2908894_+|HAD-IA-family-hydrolase	gnl|CDD|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.50374e-43
NZ_CP043006.1|WP_148385148.1|2899390_2900857_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	3.12567e-19
NZ_CP043006.1|WP_148385141.1|2892931_2893669_+|response-regulator	gnl|CDD|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.01015e-43
NZ_CP043006.1|WP_148385157.1|2904740_2905127_-|helix-turn-helix-domain-containing-protein	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	3.5219e-05
NZ_CP043006.1|WP_148385173.1|2912908_2913334_+|hypothetical-protein	gnl|CDD|367663	pfam03795, YCII, YCII-related domain. The majority of proteins in this family consist of a single copy of this domain, though it is also found as a repeat. A strongly conserved histidine and a aspartate suggest that the domain has an enzymatic function. This family also now includes the family formerly known as the DGPF domain (COG3795). Although its function is unknown it is found fused to a sigma-70 factor family domain in CC_1329. Suggesting that this domain plays a role in transcription initiation (Bateman A per. obs.). This domain is named after the most conserved motif in the alignment.	3.49331e-05

Protein sequences

>NZ_CP043006.1|WP_148385159.1|2905142_2905352_-|addiction-module-toxin,-HicA-family
MAECSELKRTLFKAGWIMLRQGKGSHIILVHPGRPGIEIVFPDHGSDDIGKGLACKILKLAGLSNNSFD
>NZ_CP043006.1|WP_148385157.1|2904740_2905127_-|helix-turn-helix-domain-containing-protein
MKRYTFIVEKTDTGYSAFAADDKVPVVTTGADMPQLRKNILDALNTWLDIKHMKPAVEKELIIRLDLAQFFEYYKVINSSALAERIGISQSLLSQYANGIKNPSDKQVNRILTGIKALGQELTYLELI
>NZ_CP043006.1|WP_148385155.1|2903425_2904580_+|redoxin-domain-containing-protein
MYKTVKTVITGSLMTLASLSLSAQTAFQVKGMLKDTSRNGDKITLAYFNGVKKVYTGAVINGNAFTIDGTITDPARATLSISTTKEMRKINPWVMSEKCEFFIEGGTVTVEGMPLPQAVITAPGQSQKDLLALKAKLKPFHEMETASNDAMLQAIIARDTVARDKHRATNDRSKQQIDSVEVAFMVANPSSHVSLDLLQERVNAKSLAEEKEKLAAWYGNLAGPLKKTVVGKQLSEQIETAFKLGPGKPAEDFALNDTLGKPVHLSSFRGKYVLLDFWASWCIPCRYENKTVVKAYERFKDKNFTVLSVSLEKPGDRKAWVEAIQKDGLTWTQVATLTSEESSEVRKRYGIRSIPMNFLIDPQGEIVAVHLRGEALAQKLEEVL
>NZ_CP043006.1|WP_148385152.1|2901838_2903395_+|hypothetical-protein
MKRSIIIILAAYITLLSACYKDTGNYDYKEINEVRITGMASSYAATFALDVLHIEPQIETTQEMTDPSRLSYYWILYKGTTAVDTLGHSPVLDYPVNVSPDNYTLFLRIVDNVTGIAWKSGTTLTVGTAYSTGIMLMGTGENGNAEVDMITMVGDTVVVRGILSGSGLPALQDPVTILHNGNKDTSSNYGRLWVMTKSGSYYIDRKTMQGNTSRNFGSIVVTTDNLNKESLTPILYIPQIRDRAGNVGNAYARAIMTSDGNIFPTHSWLVGGDFYTNPVNREQTNFGKLIKTAPFLFYAIGNMNAMMWYDTEGQRFMNYATFGTGTFSTVPTDNAADAFPWNQSATGRTLVYGENTRNTDGGATNGNSFAIMKDNSNQYFIYKFYASGATPIKRDAYTVNAIATDFDKADFYAFSSRRSVVFYSVGNRLYAYDYNKGFEKLYQFSDLGSDEITMLKFDTQIDFSSNTLYIGTYNASTKGRLRRFTVGTDPNTVTISPVENADWDGLIKIRSMSWRAVN
>NZ_CP043006.1|WP_148385150.1|2900883_2901741_+|DUF4843-domain-containing-protein
MKRMIYGLLLALVLPLASCKKEMMGYEGMEGVYFAVQSGPSYALPSSWPYRPYTNIEFVKYTADVQELTVNIKVMITGPVRDYDRPFKVAVNPDSTTAESGVHYQPVGETFTIPANEIAGYIPVTVKRTPDMAFGNKKIGLRLIANEHFGLAFPDWKAIPGLGESSLGTDTAFDATLHVINVNDLMVQPAVWRGSVVAATNRETGSWGAFTRKKMELMFQLFNLTYEDFSSETTMTLVLSNLITTELARYLVDQFNAGTPVKEDDGRLMWAGNVPWTSIIGVPYE
>NZ_CP043006.1|WP_148385148.1|2899390_2900857_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKIKIVSICMMLTFLLGACSKWIDVKPSDRLAEDQLFTTRQGYLTALNGVYAELTHAAIYGEQMTVSGLDVLAQYYYMTASTHRFYDFATFAYASDRTKPVFDNMWKKAYELIVNCNVVIDKCGEGGNPLLPAPYFGLVKGEALALRAMLHLDMLRLFGPIWSEADKDLPCIPYNTSSKPESSDLLGSAEIMQHIIDDLTAAVDLLEDADPVITEGVRHAANPNGANDLYFRQYRLNYYAAKALLARAYLWMQDKESALREAQEILAAVLDPGKPVFKIGVANPAAIPADFDHMIVSEVMFSLYTINRQNIYTTFFSPDIQREVRLSFNNNDDNQSRKNGMYDDQNDYRLKAWMTQNNTNGSFLTHVKFDVTTNAPGPNMMPLIRLGEVILIAAECSNTLDEGTAYLNMLRTGRNCVSLAPSSADQLKDYITREFRKEVIGEGQMFFYYKRNSMDRVPNHASLAGTKQMLPGNYVVPLPVSEIAVRGN
>NZ_CP043006.1|WP_148389909.1|2895935_2899280_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRVTALVCTGILLSAQLLLAAPVFSQDHEQKVISLNYVQAPIKEIFSAIEKKADVIIMYMATEDLKKEKASISTSGKRVAEVLDELLKPRGIRWAVRGNIIRLYPEKAEGDDAAVSSARDTTISVTGKVTDAAGSPIPGATVLVKGTRLGAKTDENGNFSLSGVPPNSVLQLTSVGYEPMEVRAKAGLQLSVRMQPAVLTMKDQVVTGIYQRKKESFTGSSATFTVEELKMVGNQNPLQALKTLDPSFAIIENNTFGSDPNRLPDIEIRGKSSVIGLTEQYGTDPNQPLFILDGFETTLAVISDFSMDRIESITLLKDAAATAIYGSKAANGVVVVETKRPAAGRLRLNYNLNTTFSFADLSDYNLMNAEEKLEFERLSGFLGSIDANGNFVTDVGDAKYNQRLAEVRRGVNSYWMNEPLRFAATHRHTLFAEGGDANLRYGASLSYGENQGVMNESGRKLTNGNIRLIYRKGRIAVTNSLSIDIVNATRESVPFSDFSRANPYFRKYNAEGGIDKVLESFSYANIATGQPVTTETYYNPLYDLHNKNVNRSESQGFTNNFEIEWRMLDELRARARVGINRIAIRNEVFRSPFNTEFAGVDPLRQGTFYESNDRQMNYDGDLSLTYGKLLAEKHMLNVVAGMRLNQIASTGSGYEVRGFVGEDFPNAAFAFGYSDSRRASYQESIRRSASFFLNTGYAFDQRFLLDATLRSDGASVFGSNRQFTTIWSTGLAWNIHNEAFFKDASYDWLNSLRIRASIGNPGNQNFSDYVSARVYRYNNENRNPFGPSVIVSNHGNPLLKWQKTLDRNIGLDFQTAKNRLRINADYFVKTTDPLLVFVSVPSSSGATSITDNLGGQEQTGFTFTASYTAIQRKAFTWMFNVNGRRLRSRYTNFGNALSNFNENNKGVNMTRYYDGASPSDLWAVRSMGIDPATGREVFLTKEGNHTFVHNYNDEVVVGNSDPDLEGILGTFLSYKGFTANVALRYRFGGQIFMQTLYDKVENIPYQNIGLNQDRRALSERWQQPGDNAKFKAIAETRSTPMSSRFVEDNNILSGESISIGYETSAARWLKAIRASSVTFRAYMNDIFRVSTVMNERGIDYPFARSVSLSMGVRF
>NZ_CP043006.1|WP_148385146.1|2894950_2895505_-|RNA-polymerase-sigma-70-factor
MATDHTAYTILLTQLQQHDLAAFDHLFHHARKRLYVLAYAITQDAEAAKDIVQEFFIDFWTNRRYEHIERSLEHYMLYAVRNRSLKHNRHQASLAEKTQLLPQNSATTTLHHLEQAELKQEMDRAIRQLPPMAGKVFQLHYIEHLPHAQIAEQLGISKSTVSSHMDRALRELRTVLKKNIENLR
>NZ_CP043006.1|WP_148385144.1|2893764_2894907_-|DUF4974-domain-containing-protein
MKNLTAHQEYLLLGKVSNTLSEQESEEWEQMVQHVPEVAIAYEQFMQQLPAGDVAGRFSYVDEPGYWDDLTASFKEPARIRRLPFGRRRWVAAAIAIGVLAGSALLWNNLRKQDTATNMAATAKPGVELRLADGSVVNLSRQQGNIQTGATQLNNTNKRLTYSSSDADASVINILTVPVGLDYKISLADGTEVWMNSATELKFPLAFPDATREVSINGEAYLKVAKDPAKPFIVHLPNSTVQVLGTEFNVNTYDPGTAKVALIEGAVNMRSLSGESTLAPGRQAIYQDGQAIQQRTFDAKVVLGWQKGLFFFDEMPLKEIAKVVPRWFGMQVIIDDPAISDKKFVGVLDRNQPISAFQDDLKLIAGIDSYVDKDNVLHFR
>NZ_CP043006.1|WP_148385141.1|2892931_2893669_+|response-regulator
MINCAIIDDEPLARDGMAGYVRDISFLTLAATCESAVEYSTLPPQQTVDLIFLDIQMPKINGLNFLKTMQHPPMVIVVTAYPEYALEGFQLNVLDYLLKPVTFDRFFQSATKARDYYHLLKKNHTSDVSPAGGTADYFFVKCGTKYEKVYFDDVLYVEGMQNYITIHTRRGKYITMHYLKTLEENYLNNQLFIRVHKSYIVSVNKIESIQGNEIVIGTHRIPVSRSYREQVMQQVVMNKLWDKSK
>NZ_CP043006.1|WP_148385162.1|2906885_2908217_+|DUF2130-domain-containing-protein
MATSITCPNCKHPFVMEEAFAADIEKEMRGKMETEWRKRMESLQAEKHEMAQLRQQVAAERQQVLQDRQRQEEELNIRLQAEKIKLQESLMENIRKDVSADFENKLRMLQEAQQESEEKLRTARQKELDFLRKAQELANREQELEIDLQKRMLEERSRLMEQIRKEELERTNVKETEYQLRQKELEKQLEDQRRLVEEMRRKAEQGSMQLQGEVQELALEEMLRSTFPFDAVSEVGKGVRGADCIQTVRNQFGQECGKIIYESKRTKDFSREWIEKLKADMRGQGADVAILVTQAMPRDMERFGERDGVWVCTFSDVKSLAYVLRDAIMKVYHSARSQENKGDKMHLLYHYLTSGEFAEQWSAIREGFRSMKTSIQREREAMEKLWKAREKQLEKVLLNAAHIKGSIEGIAGSDSVDLQLLDDAAEALLAPPNGTRKPEQDNI
>NZ_CP043006.1|WP_148389910.1|2908273_2908894_+|HAD-IA-family-hydrolase
MKDRTYQSIIFDLGAVLVDWNPRYLYSKVFATPEETDHFLENICTSDWNEEQDAGRSLAEGTELLVEKYPDFEAQIRAFYGRWREMLGGPIQETVELLQQLKASGKYKLYALTNWSNETFPIALMEYEWLQWFDGIVVSGKEKLRKPFPDFYQLLLDRYMIDKTNAIFIDDNIRNVKAAEEMGIETIHFQTSAQLGEELQQRGILN
>NZ_CP043006.1|WP_168208785.1|2909264_2909903_+|DUF4136-domain-containing-protein
MKRTGLLLSTIAIGALLFSACRKEPLNDMTEEESRIYVTNYDEEADFTAYGTFSIVDSVAVISNNDATRELTDYDVKLLAAIRSNLTARGYAEVDKDADPDLAVNVARINTSSTSVYYPGYWAGWPGYWDPGYWGFPGWGYYFPPYYSVFRYNERSVAIDMVDLKSPPKEEDKLTAVWNAMLRGTGVWNSANIDTMIQAVFDQSAYLTTSAN
>NZ_CP043006.1|WP_148385167.1|2909929_2910553_+|outer-membrane-beta-barrel-protein
MKSIKLIILIMAGTLAMHTAFAQSRPPLSFQLNYSITQPFGSLSDDYADNTSFRGWNFGFQYALNDRLSLGARVGFADFYERLPRAVYPGKGEDISAVQTRTLQTIPIMAAAQYTFAGPDAKVMPYAGLAVGMANMNYEKFWGEFVEKHNKWAFQVSPELGLNVPFGKYSPVMFNANVQYNYAAYKYAEISNFNTLQANIGLRFHIR
>NZ_CP043006.1|WP_168208786.1|2910616_2911594_-|FAD:protein-FMN-transferase
MMICIATGAAAQEPVTLQGQAQGTYYIIKFIATGHDTAMLHEDIRDIFQDIDRSLSLYHSGSLINRFNKGPKVVMDDHMRAVVKKAQEVSKLTDGSFDITVKPLVDLWGFGVTPHKNGRPSAEAIRRTLRVVGYQNLIIRAKYLIKKKDGVEIDCNGIAQGFTSDVLGRFLQSRGIRDFLVDVGGELVASGVNARGLPWSVGIERPPAAGNVEEPVQAILQLRDRAVATSGNYRRFFDDGGTRFAHTIDPKTGEALHNNIITVTVTAPDAITADAYDNALILLGVEKGLQFVQQHPKLKLEAYYIFKDAEGRITERHSPNFFAAP
>NZ_CP043006.1|WP_148385171.1|2911636_2912815_-|acyl-CoA-dehydrogenase
MHQDLFQSPDYYLIDDLLTNEHKMVRDSVRQWVKAEISPIIDDHCQRAVFPSHILPGLGALGCFGPTIPAEAGGGGLDYIAYGLMMQELERGDSGIRSTASVQGSLVMHPIYTFGSDVQRQRFLPRLATGELMGCFGLTEPDFGSNPAGLLTYYEEDGEDIILNGAKMWISNAPFADIALVWAKDPEGKIRGVIVERGMEGFSTPETKNKWSLRASATGELVLDNVRIPKSNILPGARGLKAPLSCLSSARYGIAWGAIGAAMDCYDTALRYAQERVQFDRPIGGFQLIQKKLAEMITEITKAQLMNWRLGVLRNEGKATAEQISMAKRNACDTALNISREARQILGAMGISGEYPIMRHMMNLESVVTYEGTHEVHLLITGMDITGLNAFS
>NZ_CP043006.1|WP_148385173.1|2912908_2913334_+|hypothetical-protein
MAKLLPVLLLAVFLTFVIASFSSKTLRNAAPGAKTDSVPAVEIKQYWMVFLKKGPNHGQDTAAEAIIQKKHLRNINRLASEGKMVLAGPFGGDGDLRGIFIMDCEDSLEVVELVKSDTAIATGRLDFEIEPWWTAKNCLFQ
>NZ_CP043006.1|WP_148385175.1|2913343_2914150_-|orotidine-5'-phosphate-decarboxylase
MNRQELVRLIRERKSYLCIGLDTDMHKIPKHLLSYPDPIFAFNKAIIDATKDLCVAYKINTAFYECQGIRGWESLQRTVDYIPEDIFTIADAKRGDIGNTSTYYAKTFFETYGFDSVTVAPYMGRDSVEPFLAFSQKWAIVLGLTSNAGAQDFQMLRTDDGYLYEKVLKTTAAWGSPENMMFVIGATQADSVAAIRKLVPDHFFLVPGVGAQGGSLKEITMKGRNKDVGLLVNASRAVIYAGNDENFADDARRAALQYQQEMAGYLGE
>NZ_CP043006.1|WP_148385177.1|2914267_2915137_+|TIM-barrel-protein
MKKYMIFLLFLVMQSSFLQSNAQQKTMPELGVATSFDNDSLLHAAGYSYIEESARKLLAPSVNEATYRQQLKKLKRMQLSVPSCNLFLPGTIRLTGPEADEKVILGFVDSLMQRAKEAGVQIIVFGSSGSRRLLEGQDPVQAKKELIAISRKMAVVAQRYGRIIAIENLNSKEDNFINRLSIVTEIVEAVDHPNFRITADIYHMKMENEDPSAILKAAPYLVHCHIAEKEGRAAPGKSNEDFLPYFAALKQAGYKGRITIECRWESLKDECRPAYEYLQQQLAAAYAIK
>NZ_CP043006.1|WP_148385180.1|2915186_2916554_+|Gfo/Idh/MocA-family-oxidoreductase
MTDKKNRREFLKLSMMGGAGVALSAMGMPASSYGRIIGANDRVNVGVVGFSDRFRQALMPCFLNHKNKLNFDIVAVSDIWNRRRDEGQKILSEKLGHKVQACMNNDELYRIKDLDAVIIATADFQHAFHTIEAVKNKKDVYCEKPFAETMEDARNALKAVKESKRVFQVGTQRRSGGTYHQAAKFIQDGKFGPITMVEMTWNVNQPGRWRRPDLVRSIRESDVDWKRYLCSRPDDNWDPRKYLEYRLFWPYSSGIFGQWMTHQIDTVHWFTGLKHPRSAVANGGIYQWKDGRTNADTLTAVFDYGPSNDPSTGFQVVYSSRFHNSAGGTKELYYSNGGMIDMSTNKITPTGGLKEREAAEMGMKPNLLPSMDLSAEAAKVETSANTGGDSTTDAHVRNWMECVRKQDVHTNAPIEAAYSHSIALIMGTAAYRSGMKATFDEARQDVMVGGKVFTL

Crispr_ID: NZ_CP043006_7

• CRISPR_ID: NZ_CP043006_7
• CRISPR_location: 3831284-3831374
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_7

Consensus_repeat	Method
GAACCGGTTATTGTTTCGCTTCGTC	CRISPRCasFinder

spacers of NZ_CP043006_7

>7.1|3831309|41|NZ_CP043006|CRISPRCasFinder
AATGGGAAGCGCTTCACGGCGGAGCAACCTGCAACGTATGG

CRISPR arrays and Neighbor proteins around NZ_CP043006_7

CRISPR arrays

The CRISPR arrays of NZ_CP043006_7

>merge|NZ_CP043006|7|3831284-3831374|CRISPRCasFinder
GAACCGGTTATTGTTTCGCTTCGTCAATGGGAAGCGCTTCACGGCGGAGCAACCTGCAACGTATGGGAACCGGTTATTGTTTCGCTTCGTC

>NZ_CP043006|7|5|3831284-3831374|CRISPRCasFinder
GAACCGGTTATTGTTTCGCTTCGTC	AATGGGAAGCGCTTCACGGCGGAGCAACCTGCAACGTATGG
GAACCGGTTATTGTTTCGCTTCGTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148386845.1|3846527_3848108_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|185760
NZ_CP043006.1|WP_148386838.1|3840256_3841030_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293819
NZ_CP043006.1|WP_148386841.1|3843531_3846510_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148386794.1|3821928_3823482_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
NZ_CP043006.1|WP_148386828.1|3832686_3833382_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|180838
NZ_CP043006.1|WP_148386807.1|3825292_3826744_+|glucosylceramidase	unknown	unknown	gnl|CDD|227807
NZ_CP043006.1|WP_148386822.1|3830827_3831148_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380366
NZ_CP043006.1|WP_148386815.1|3827808_3828747_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|131350
NZ_CP043006.1|WP_148386832.1|3834820_3836185_-|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
NZ_CP043006.1|WP_148386785.1|3817079_3818249_+|DUF4974-domain-containing-protein	unknown	unknown	gnl|CDD|226235
NZ_CP043006.1|WP_148386811.1|3827020_3827701_+|DUF1080-domain-containing-protein	unknown	unknown	gnl|CDD|368908
NZ_CP043006.1|WP_148386789.1|3818551_3821908_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148389959.1|3833391_3834534_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386836.1|3836239_3836629_+|VOC-family-protein	unknown	unknown	gnl|CDD|319940
NZ_CP043006.1|WP_148386848.1|3848265_3849249_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386803.1|3824438_3825296_+|family-16-glycosylhydrolase	unknown	unknown	gnl|CDD|185693
NZ_CP043006.1|WP_148389960.1|3836864_3837584_+|rhamnogalacturonan-acetylesterase	unknown	unknown	gnl|CDD|238859
NZ_CP043006.1|WP_148386819.1|3828919_3830773_-|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|274511
NZ_CP043006.1|WP_148386799.1|3823509_3824343_+|hypothetical-protein	unknown	unknown	gnl|CDD|214510
NZ_CP043006.1|WP_168208985.1|3837739_3840061_+|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl|CDD|227721

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148386845.1|3846527_3848108_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	2.98148e-32
NZ_CP043006.1|WP_148386838.1|3840256_3841030_-|MBL-fold-metallo-hydrolase	gnl|CDD|293819	cd07733, YycJ-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis YycJ and related proteins; MBL-fold metallo hydrolase domain. Includes the uncharacterized Bacillus subtilis YycJ protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	3.74629e-42
NZ_CP043006.1|WP_148386841.1|3843531_3846510_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_148386794.1|3821928_3823482_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	4.47625e-27
NZ_CP043006.1|WP_148386828.1|3832686_3833382_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|180838	PRK07102, PRK07102, SDR family oxidoreductase.	1.76002e-56
NZ_CP043006.1|WP_148386807.1|3825292_3826744_+|glucosylceramidase	gnl|CDD|227807	COG5520, COG5520, O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane].	7.33788e-66
NZ_CP043006.1|WP_148386822.1|3830827_3831148_-|cupin-domain-containing-protein	gnl|CDD|380366	cd02238, cupin_KdgF, pectin degradation protein KdgF and related proteins, cupin domain. This family includes bacterial and archaeal pectin degradation protein KdgF that catalyzes the linearization of unsaturated uronates from both pectin and alginate, which are polysaccharides found in the cell walls of plants and brown algae, respectively, and represent an important source of carbon. These polysaccharides, mostly consisting of chains of uronates, can be metabolized by bacteria through a pathway of enzymatic steps to the key metabolite 2-keto-3-deoxygluconate (KDG). Pectin degradation is used by many plant-pathogenic bacteria during infection, and also, pectin and alginate can both represent abundant sources of carbohydrate for the production of biofuels. These proteins belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	5.07316e-37
NZ_CP043006.1|WP_148386815.1|3827808_3828747_-|helix-turn-helix-domain-containing-protein	gnl|CDD|131350	TIGR02297, AraC-type_DNA-binding_domain-containing_protein, 4-hydroxyphenylacetate catabolism regulatory protein HpaA. This putative transcriptional regulator, which contains both the substrate-binding, dimerization domain (pfam02311) and the helix-turn-helix DNA-binding domain (pfam00165) of the AraC famil, is located proximal to genes of the 4-hydroxyphenylacetate catabolism pathway.	1.1889e-21
NZ_CP043006.1|WP_148386832.1|3834820_3836185_-|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.18658e-46
NZ_CP043006.1|WP_148386785.1|3817079_3818249_+|DUF4974-domain-containing-protein	gnl|CDD|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	2.35167e-23
NZ_CP043006.1|WP_148386811.1|3827020_3827701_+|DUF1080-domain-containing-protein	gnl|CDD|368908	pfam06439, DUF1080, Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	5.53689e-38
NZ_CP043006.1|WP_148386789.1|3818551_3821908_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_168208985.1|3837739_3840061_+|alpha/beta-hydrolase-fold-domain-containing-protein	gnl|CDD|227721	COG5434, PGU1, Endopygalactorunase [Cell envelope biogenesis, outer membrane].	2.48169e-88
NZ_CP043006.1|WP_148386836.1|3836239_3836629_+|VOC-family-protein	gnl|CDD|319940	cd08352, VOC_Bs_YwkD_like, vicinal oxygen chelate (VOC) family protein Bacillus subtilis YwkD and similar proteins. uncharacterized subfamily of vicinal oxygen chelate (VOC) family contains Bacillus subtilis YwkD and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.72071e-77
NZ_CP043006.1|WP_148386803.1|3824438_3825296_+|family-16-glycosylhydrolase	gnl|CDD|185693	cd08023, GH16_laminarinase_like, Laminarinase, member of the glycosyl hydrolase family 16. Laminarinase, also known as glucan endo-1,3-beta-D-glucosidase, is a glycosyl hydrolase family 16 member that hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans.	1.92247e-105
NZ_CP043006.1|WP_148389960.1|3836864_3837584_+|rhamnogalacturonan-acetylesterase	gnl|CDD|238859	cd01821, Rhamnogalacturan_acetylesterase_like, Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are highly branched regions in pectic polysaccharides, consisting of repeating -(1,2)-L-Rha-(1,4)-D-GalUA disaccharide units, with many rhamnose residues substituted by neutral oligosaccharides such as arabinans, galactans and arabinogalactans. Extracellular enzymes participating in the degradation of plant cell wall polymers, such as Rhamnogalacturonan acetylesterase, would typically be found in saprophytic and plant pathogenic fungi and bacteria.	1.44838e-83
NZ_CP043006.1|WP_148386819.1|3828919_3830773_-|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|274511	TIGR03300, assembly_YfgL, outer membrane assembly lipoprotein YfgL. Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking].	1.05251e-30
NZ_CP043006.1|WP_148386799.1|3823509_3824343_+|hypothetical-protein	gnl|CDD|214510	smart00089, PKD, Repeats in polycystic kidney disease 1 (PKD1) and other proteins. Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.	0.000130976

Protein sequences

>NZ_CP043006.1|WP_148386822.1|3830827_3831148_-|cupin-domain-containing-protein
MNPESFQNKPSRETLPGMTGRFLHGEHHSLAYWEGKAGTLLPVHQHMHEQMTYILSGTLEMELDGVKHVLNAHDVLLIPPHTPHGGKVITDCRLIDSFSPVREDYK
>NZ_CP043006.1|WP_148386819.1|3828919_3830773_-|PQQ-binding-like-beta-propeller-repeat-protein
MRKLLFICLALCCAALTAASQDTLFRFALVTDTHVGTETGQEDLERTIADINRQPQIDFVIFSGDITEFGSDEELRLSKTIISGLNKPWHVIPGNHDTKWSESGCNSFRTVFGNETFSFEHKGYWFIGTNCGPNMRMGPGQVPRENIVWLDRQLKKQKDKNVPLIYINHYPQDSGLNNWYDVLDRLRGRNVKAMICGHGHANKAYDWEGVPGIMCRSNLRAKKPFGGYNIVAVTSGELVFNERTPGITTLKAWHKVPTTGKPAWVPDPPRPSYAMNNAYPQVKVKWQVQEAGDMGSAVAITEDKVVYTNTNGEIKALDLETGKQRWKFRTGGKIYATPLVENGMVIVPCTDGFVYCLQLKNGKPAWKKSTGKAIVSSAAAYDGLAIIAGSDGHCRAWEIATGKLRWNYDGVKGFVETKPFIYKDKVLFGSWGNHFYALDAATGSPLWDWTNGANNRMFSPAACWPVAVANKAWLVSPDRYMTVLDTDTGKEIWRFRDTANWVRESMGISRDSNRVYAKTMQGHVLAFNARSQEREMLWKSPVEMGYEICPSPLNESNGILYVPTGSGVVYALSAADGSLRWKHKFSNCLVNTAQPVDGNKLITSSMDGKLLCLEITE
>NZ_CP043006.1|WP_148386815.1|3827808_3828747_-|helix-turn-helix-domain-containing-protein
MQKPINIKNPQEFKTHYLLDPPSSWCEAGQTNTGPAFMEVVPLEKLRPSMKTGTAATRRNFYTMVVITAGSARETIGHRTWSFDAGTIYFIPENVLHSTEHWSADIKGFHCIFDTDYFLLCLRNQVKLQLYPFFQPEKQPFLKLSPSSAKPVTELFSKLNMEHCRRKTLNDDLLVRLYLNVLLIELERLYLRQQQVKETALPKQQLLVAQFKKLISEYYTEKRQVSDYAGMLYVSPGYLNDTIREQTGKPASYYIQEQVILEAKAQLVQTEQTVSQISLNLSFSDTSYFCRFFRRHTGSSPEQYRQKVFLRD
>NZ_CP043006.1|WP_148386811.1|3827020_3827701_+|DUF1080-domain-containing-protein
MQNFLVIIASFLTITASAQTRSLFNGKDHQGWHIDVPAMDKDAQAPSPFIIRDGMMVSLANPQGHIITDSSYKNYRLQVEYRFPGKPGNCGVLVHASTPRVLYGMFPKSVEVQLMHRNAGDFWCIGEDIAVPEMEKRRGPKENWGAVDGKERRIINLTDNSERPLGEWNTMIVECLGREVKVWVNGDLVNHGHDCTVSEGQIALQAEGSEVEFRKVMLTPIRKLTK
>NZ_CP043006.1|WP_148386807.1|3825292_3826744_+|glucosylceramidase
MSKKLWLAIAPLLLSVSLSSAGCKSGGGTPDPIDPPGPGPVTSDVAMWLTKPDRSVLFAPQQVSLVFRDTFNVYPTITVDESQTFQEIDGFGYTLTGGSASLINALPATAQEALLKELFHWDSTFIGVSYLRVSIGASDLSAHTFTYNDLPEGQTDENMAHFSIAEEQKDLIPVLKKIVALFPQIKILGSPWTAPVWMKTNKAFVGGSLKPEYYAAYAGYFVRYIQAMESEGITIDAITPQNEPLHGGNNPSMVMQAAEQADFIKHHLGPAFQAAGITTKIIVYDHNADRPDYPVDILKDPQASAFVDGSAFHLYGGQISALSQVHDAYPEKHIYFTEQWVGGPGNFAGDLQWHVSNLIIGATRNWSRNVLEWNLAADPAYDPHTPGGCSTCLGALTISGANVSRNVAYYIIAHASKFVRPGSVRIASDVAGSLENVAFKTPEGKKVLIVLNSGSIPQRFNIRYNGKLVTSELVNGGVATYVW
>NZ_CP043006.1|WP_148386803.1|3824438_3825296_+|family-16-glycosylhydrolase
MKTVQYGLILLIGLHAMACSGQEKDGPGPVTPPSQGPQDKGWTFETTPVWQDEFDYNGLPDAAKWGYDIGGHGWGNNELQYYTNRIENAFVGNGVLTISAKKEAMSGRNYTSTRLISKGKGDFLYGRFEIKAKLPAGKGTWPAIWMLPTDWAYGDWPKSGEIDIMEHVGYDPNKIHISVHTEAYYFKIGTHKTSTKVIENAMTEFHLYRVDWTPYAIRGYIDDVLIYQFINEGKGYTVWPFDKRFHLLLNIAVGGDWGGQQGVDDNIFPTNMEIDYVRVYKMIDK
>NZ_CP043006.1|WP_148386799.1|3823509_3824343_+|hypothetical-protein
MRALYITGCMLLLAACTPESSTISLQPLPTAAFTATPLSGNPNKVAVQSTTPGGFIWLWNYGTNGISRKASDTLSFSKKGEYTIQLTVFTHGGYATTAQKVNIANDLPAVDILKGGDMSPGSEAFWTVLNTGGTQTAIAIANGMMTFSNTGNSNGAIYQAVTVKKDREYTFSAHIKGGGAADTWFEVVFGTAAPEQGKDYSGTKFIAMNTWSGCGNAPFDGEFAVIACDGDGKGKDGKIKFDKDGTVYMVIKGGSTNNGTLGPDGITLDNIRFLEEQ
>NZ_CP043006.1|WP_148386794.1|3821928_3823482_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKKKYIPFVVMLAAGLQLISACSTGFLDVKPRGLDLESNYYRNEEEAFKGLIAAYDVVGWQGGGYVTRVGAFNAASDDHVAGGGNSTDINSFQVFSNYTLTSEVGPHNELWRKGFSGVFRSNVILAKLPDVPMDENRKKRFIAEARFLRAYFYFDLVRMFKNVPLFSLPVSTSEMYDVLQAPPADVYKQIEDDLKAAIEEPNLPDQVPIASEGGRATKGAVHALLGKVYLYQEKWALAAAEFAEVNGATPGQVNAKYGYRLLADFGDLWKSDNASKFNSESIFEIAFTSTSAGTWDCVACTEGNVLNIMVGPRGYKALTADAPDYVSGWSFLPVTQSLFDAIHFDPRYRYTVANLDSLEENGIAEYEKGYMNTGYFLEKLAGRVSNRTTGGGSQELNYPQNLYEIRLADTYLMEAEALVRNGESGGTGTRSYNLLNAVRARVGLTPVPATIDNIFRERRLELAGEGHRWFDLVRSGQAAAILGPRGFVPGRHEILPIPLLELENTKLEQSKEWGGTK
>NZ_CP043006.1|WP_148386789.1|3818551_3821908_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKLTTVLLFAACMQISAKGVSQQISISERNAPLKKVLKEVARQAGISMVYDETLLSRLKPVTIELKNVSVQEAMRSLLKGQPVAYTIEGKRIIIRQPEPEELQALDTAITVSGRISNDAGEAIPGATVRVAGTSTGTASDANGRYTIRVPDANASLIFSVLGYNTRTLKVSGSSMDIKLQLSETALTETVVVGYGVQKKSVVTGAISSVRAKDLEDMPITRLEQALQGRTSGVTIAQSSGQPGSGAAVRVRGITTFGNNDPLWVVDGVVVDNGGIGYLNQYDIESIEVLKDAASQAIYGARAAAGVILVTTKKGKAGKLTVNYNGYYGISAPARKLKLLNATEYATLRNEASVANGNGIVYADPESLGKGTDWQSHIFNSSAQRQNHEISVSGGSDRSTFYTSFGYLQQEGIVASDISKYQRFNVRLNSIHKLTPWLTFGENVGYAYDKNVGLGNTNSEFGGPLSSAINLDPITPVVITDPAIAGAAPYTNVGIRRDALGRPYGISSAVGQEMTNPLAYISTRIGNYGWSHNVVGNTYLEAEPLKGLKLRSTLGAKIAFWGSESFTPLSWLNSSNISSRTSFNRSSNSGYNWNVENTIAYSRSIGDHNFTVLAGQGAYMDNRTRSINVTFNDVPADNFNDASLNFKVPADKRLSDGSEGADHRIASLFARVNYNYDEKYLLEAIIRRDGSSRFGSNNKYGVFPSFSLGWVASRESFWPENQVISFLKLRGGYGVVGNDNIGNFAFLSTIGSGRNYAIGNSGSYLIGYSPNAPSNPDLKWEETSQANIGFEATLFRNVTLAFDWFKKATKDILQNPRIPSYVGAISNPAANVADMENTGVELELGYRQTIGEFDFSLNGNVSYLKNKVTDLGTGIAYLSGGQSFQTMGTITRTAIGQPINSFFGYRTLGIFQTQDEVNAYVGKDGAMIQPNAKPGDFRWWDKNGDGMITEDDRDFIGNPTPAWTYGFTANAAWKGFDIVLFGQGAGGNKIFQGLRRLDIANANWQTKALDRWTGPGTSNEHPRLITGDPNKNFTNSSEFYLEDGSYLRIKTLQLGYTLPNSLTGRIGLQRLRVHVMSENLVTFTKYTGYDPEIGGGVFSIDRGIYPQARSFMFGLNATF
>NZ_CP043006.1|WP_148386785.1|3817079_3818249_+|DUF4974-domain-containing-protein
MAPHEELLQKYLDGQCTREEAEALMQWLQTTGSHRTLLASMQEEFERSMDTQVEIPAAISDRIENRLLQEISASGKVVDMRPRNRRYWFAAAAVALLLAAGIYRYNTDRPAPMPLARAEQTTEDIAPGSDKAVLTLANGTTVTLDSAGNQVIRQGGTTVLQQKGQLQYESEPDEGTVGYNTLTVPRGGQFHVVLPDGSKVWLNSASSLKYPTAFTGNERLVELQGQGYFEVSRNAQQPFLVKVGHMEVQVLGTSFDVMAYSDESSVNTTLLEGAVKVKQGSTGQVLKPGQQARYDRQTCKVTVHPADVQQVVAWKTGFFEFDNAKLSDIMRQVARWYDIDITYMNEQTSAVYGGRISRSLPLSEILHMLEPNGARFTLDGRKLKVSSTE
>NZ_CP043006.1|WP_148386828.1|3832686_3833382_+|SDR-family-NAD(P)-dependent-oxidoreductase
MQKVVLVLGANSDVAKAAIGLYVDKGYKVIAASRSLDDLRALPVETLYFDAADFDSHRSFYESLPQKPHIVLYAAGYLKHNEEALLDWEGSFRMMKVHYCGAVSILNIIATDTANPHLERIIGLSSLSGVRGRKSNFIYGSTKSAFTQYLAGLRQYLFPRGVTVNVIVAGYIRSKMTAGLDLPESLMLEPAFIAKAITGAGKGFTIVPGLKWKFIYQVLRLMPERLVAKLP
>NZ_CP043006.1|WP_148389959.1|3833391_3834534_-|hypothetical-protein
MTSGSTYQAASKVAAPIAEHFAKHLACAEKNGEEDLASAPSEMIVQKIIDVAFWASLRKEEGITTRISIAFMNPDEVGKPLLFGHRLPFGVKMLTKLAPGVERAGVHVGVWHEGGELYIWGTTIQLPNYCFVVDVSEPGLLVVKHRRITGLGKFTNVAVLRGDQIKIVNEDSGLLPDSPPILNSLLGIDTSAVWNNPVNVLIQIAVSMRAHRRGGILLVTPSNHEGWKESIVHPMQYPVSPAFCGVADLIRQDSDKVSEIYWQTALRREVENVTGLTAVDGATVVNDQHELLAFGVKIARASWSTPVDEVLFSEPIVGGIPLQIHPSKIGGTRHLSAAQFIHDQRDSLALVASQDGYFTVFSWSEATQMVQAHRIDILLI
>NZ_CP043006.1|WP_148386832.1|3834820_3836185_-|Gfo/Idh/MocA-family-oxidoreductase
MHTFHLNRRHFLKGATASLLLSSLGAQALDFIDPAKSYRVGLIGTGWYGKSDLFRLIQVSPVNVVALCDVDKNMLAGAAEMVAQRQKSGARPKLYTDYRKMLEDHKLDIVLIGTPDHWHALNAIDAIKSGAHVYVQKPISVDVLEGEAMVATARKYNRVVQVGTQRKSTPHLIEAKKNIVDAGLLGRISHVEMCCYYHMRNNGNPPVQEVPDFFDYDMWTGPAPLRPFDGMPHQRWWRAFMEYGNGITGDMCVHMFDTVRWMLQLGWPKRITATGGIYVQKTGKSNIADTQTAVFEYDNLNCVWQHRTWGTPADPKYPWAFTLYGEKGTLKASTMAYDFIPQGKGEPIHKDVVYEKEKYPEDVTEPGIELNAAPATRLHMLDFLKAIETGSRPVADIEEGHISTASCILANLSMHTGRPLVYDPEKRIITGDREATALLQRPYRNPWEHPAAML
>NZ_CP043006.1|WP_148386836.1|3836239_3836629_+|VOC-family-protein
MLKLNKVHHIAMICSDYERSKRFYTEVLGFEIERETYRAARGSWKLDLSLQGNYIIELFSFPDPPPRPSRPEAQGLRHLAFEVDDVDAAVNALQAKQVNTEPVRVDELTGKRFTFFSDPDGLPLEIYER
>NZ_CP043006.1|WP_148389960.1|3836864_3837584_+|rhamnogalacturonan-acetylesterase
MKSLAVCLLLSLLLPAKERMTIWMIGDSTMSVKKPAFYPETGWGMALGAFFRDDVRIENRAMNGRSTLSFIREGRWQAVVEGLQEGDYVLIQFGHNDEKTDKPGTGTSHEAYKANLARFVREASAKKAVPVLLTSIARRHFEHGVLLDTHKGYPGAMRELADSLQVPLIDLEQETSRLLRELGEDGSIRLFLHVPAGHMNYPSGKQDNTHLSPDGAKAVAALAVEGMKARGLDLEQYLR
>NZ_CP043006.1|WP_168208985.1|3837739_3840061_+|alpha/beta-hydrolase-fold-domain-containing-protein
MNKRKTGKIFLLLAAAMSMAASGFSQYSWERLPEIRQPVFRKDTFNIKAFGAVGDGIALNSAAINNAIKECSRKGGGVVLVPEGIWLTGPVEMKSNVNLHLKSAATLLFTADKAQYPLVEGVYEGRSAARNQSPIWGKDQENVAITGKGVIDGNGDVWRAVGKGELTESEWKKKVASGGVVRKDGKEWYPSEQYRAAKEGNRSMLLAPEKTLADYADMKDFLRPNLVVLNNCRKVLLEGITFQNSAAWCLHPLLCEDLTLRDLTVKNPAYAQNGDGADIESCRNFLIEGCTFDVGDDAICIKSGKDEEGRKRGKPTENGIIRNNLVYKGHGGFVVGSEMSGGARNIFVENCTFMGTDKGLRFKSTRGRGGVVEKIYARNIFMKDIVHEAVFFDLYYFVKFATDSERDERPIVNEGTPVFRDMVFERIVCRGAKRAVFIRGLPEMPVRNISIRNSVFQAETGKELIDADNILLENVRMDIPVPRDTSFAVNSTFEKERKKYPFIRIAAPGPAKNMLHAADVPYREAGGRSLLLDVYYQDDKKPRPAVLLIFGGGWRSGDKSHNHAMAVELVKRGFVAVSAEYRLSPEARYPAAVQDLKAAVKWMRANAAAYGIDTAKIAAMGCSAGGQLAALLGATNGVAEYDTGNGYADAAAYSSYIQAAIDIDGILAFRHPESAEGAAAAQWLGGTWEERPEQWQAASALTHVSKNTVPMLFINSALPRFHAGRDDMMRAMKALNIYSEAHELPDTPHPFWFFDPWFAKTMDLATTFLQKVL
>NZ_CP043006.1|WP_148386838.1|3840256_3841030_-|MBL-fold-metallo-hydrolase
MSLFITSLNSGSNGNCYYIGNQEEAILVDAGISCRETERRMARLGLTMQKVKAIFVSHEHIDHIRGIPVLSKKYRLPVYITDGTLSYSRMQLQQTLAFRAFEPVVIGQLKITAFPKHHDASDPHSFLVTCNHTDTRIGVFTDIGIPCDQLTSHFRQCHAAFLETNYDETMLEQGRYPYFLKNRIRGGKGHLSNTQALELFKAHRPPFMSHLLLSHLSKDNNSPELVHEMFAQHANGTEIVVASRFAETPVYKVSTLK
>NZ_CP043006.1|WP_148386841.1|3843531_3846510_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKPFIRQMGILCLLLISTCIYGGIPAIPVSGTVTDKESGDPIPGVSVRIKGGSAGTVTDNKGRFSLEVPDSESILVITFTGYATRELAVGNQTSLLITLEAETKGLDEVVVIGYGKQRKGDVTSAVASVKQEDFVKGFARDAGQLIQGKVAGLAVVTSSGDPNSQTQISLRGNSTLLSSTQPLVLIDGIPGALNTVAPEDIESIDVLKDGSAAAIYGTRGTNGVVLITTKKKGAQAATITYDGYVSVQSIARKMEFLDADDYRRLIQEGFFVPTASEKYDYGTSTDWLKEITRTPVSHTHNLSLQGGNGQTNYVATINYREWEGLFKRSNNEQLTGRADINHTMLDGRLKFNLGVIGRNRKYFAAPNYAYIYRQAIIRNPTDSVYTFDGKWREDLNAYNYDNPVRPIEEVEGEDRVTEMRYNANVIFSPIRDFNIKLLLSSVKTSSVSGYFESFDHKASELSRRRGYASRGTWLFRDNLLELTGDYSRTIQRHKFTVLGGYSWQDVTNEGFSMYNSDFPTELYTYNRLQSGDQLRLQTAGAQGSGMSSYKNNHKLIGFFGRLNYSWDDRYLLMLTMRHEGSSKFGRNYKWGTFPAISAGWRISKESFLAGSSFVDDLKVRAGFGVTGTVPGDPYLSLISLNYDGASRFLYNGNWIQPLVPVRNPNPDLRWEKKEEYNFGLDFAVWRRINGSIDLYQRDTRDMLYNFPVPVPPNLFGSTIANAGRMRNRGIEILLNYDIIRTKDFNLSSNITWAYNKNTLLSISNDLYKTTNNFFFTGHTGEPIQVTTHKVEVGQPVGDFYGYKSIDIDDDGKWIIEGEDGKPKPIDDAQPDDRKVLGNGIPKHTAGWNLAVRYKKLDLSINMRGQFGYQILNYQRMYYENPTIKQYNMLKSAFDNVYGKRQLNNPLAYVSYYIEDGDHWKVDNVTLGYNLNVGGSKYFRQARVYASALNLLVLTGYKGIDPEVSRLGLEPGNDSRDKYPTTRTFTLGVNFTL
>NZ_CP043006.1|WP_148386845.1|3846527_3848108_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MRITYFMTALLLVFGSCTNLDEEVYDQVLETSFNPSESDLPAILAPAYTVMRGMYAGWQGNFDLQEEPADVIVTPNRPNGWYDAGTYHRMHKHEWPANQWQPQNVWNHCFSGINNANRIIYQIESGSIPIANGKENVIAELKAVRAFYYSILVDTHGNVPIVTDFTNVELPSQSTRQQVFDFVEQELLDNMDLLSTDVSKATYGRLNRWVAKAILARHYLNAEVYTGTPQWDKCIAQCDDIAASGKYILEPAYKTSFLTNNENSKELIFAVPYDEIFATQNIIHCKTLATAHVNVLNLAAAMWGGNCAVPQFIDTYDPDDTRLKDTWIMGPQYSVTTGALILTYTKNVPSIEGTDYFDGYRIGKFEIKPGARGGLSTDYPIFRFADIKMMKAECLLRKGLANDAALLVSEVRQRAFAATEPDKATVTGAQLLQGSVYQYGYWQPNGTVASPEGGADIQYGRFYDELGWEFAAEGHRRMDMIRFGVFSRKTWYNHRPKNDGKTRTLFPIPQAELDKNPNLDQNDDYK
>NZ_CP043006.1|WP_148386848.1|3848265_3849249_+|hypothetical-protein
MRSTLLLLTLSFTLAISCNKKDKETPDPLEPPASGETVRTRLRLTGDILATESPLPNGRLVNDVEGYARELRDSTLYSVLLQEHTSWGYWQTTSCGLFNNRDSLAIDLPVEGEFRIIVQVYKRGTGPGLYYTWKNGAQYFDEPINNTLDNRMNNGNKTRDTMWGFRLFDPLDSANYLGLVGYGEADGYRGETTVTATGTPSIISLDMKRMSFGVQFSAANFTSGKLHASSGNGGIHPKSVTPENIDDQHFIFLANEFATQDSTYGPLNVKITWEKPDGSMVPIGEKSITFKRNVLTKIQVTIPNTGRSIIDPVITETEWSGTETVEF

Crispr_ID: NZ_CP043006_8

• CRISPR_ID: NZ_CP043006_8
• CRISPR_location: 3877461-3877561
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_8

Consensus_repeat	Method
CATTGCGGGAGCGTAACAGATAC	CRISPRCasFinder

spacers of NZ_CP043006_8

>8.1|3877484|55|NZ_CP043006|CRISPRCasFinder
TTTGCATTATCAATAACCCCTCCGGGGAAGCGGGTACTGATCCGGTCGCGGTTAT

CRISPR arrays and Neighbor proteins around NZ_CP043006_8

CRISPR arrays

The CRISPR arrays of NZ_CP043006_8

>merge|NZ_CP043006|8|3877461-3877561|CRISPRCasFinder
CATTGCGGGAGCGTAACAGATACTTTGCATTATCAATAACCCCTCCGGGGAAGCGGGTACTGATCCGGTCGCGGTTATCATTGCGGGAGCGTAACAGATGC

>NZ_CP043006|8|6|3877461-3877561|CRISPRCasFinder
CATTGCGGGAGCGTAACAGATAC	TTTGCATTATCAATAACCCCTCCGGGGAAGCGGGTACTGATCCGGTCGCGGTTAT
CATTGCGGGAGCGTAACAGATGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148386904.1|3871942_3872746_-|DUF4249-family-protein	unknown	unknown	gnl|CDD|379442
NZ_CP043006.1|WP_148386883.1|3861178_3861673_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386939.1|3885237_3887640_-|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|274576
NZ_CP043006.1|WP_148386898.1|3870846_3871149_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386946.1|3889318_3890557_+|phosphoglycerate-dehydrogenase	unknown	unknown	gnl|CDD|236985
NZ_CP043006.1|WP_148386935.1|3883852_3885223_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NZ_CP043006.1|WP_148386931.1|3882164_3883145_+|cation-diffusion-facilitator-family-transporter	unknown	unknown	gnl|CDD|223131
NZ_CP043006.1|WP_148386887.1|3862153_3865132_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386943.1|3887861_3889076_-|serine-hydrolase	unknown	unknown	gnl|CDD|365903
NZ_CP043006.1|WP_148389964.1|3883199_3883856_+|response-regulator	unknown	unknown	gnl|CDD|130454
NZ_CP043006.1|WP_148386901.1|3871152_3871917_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386920.1|3878499_3880443_+|threonine--tRNA-ligase	unknown	unknown	gnl|CDD|234752
NZ_CP043006.1|WP_148386879.1|3860553_3861123_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386891.1|3869728_3869977_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386911.1|3874903_3876841_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|223562
NZ_CP043006.1|WP_148386924.1|3880548_3881349_+|translation-initiation-factor-IF-3	unknown	unknown	gnl|CDD|234582
NZ_CP043006.1|WP_148386908.1|3872752_3874837_-|TonB-dependent-receptor-plug-domain-containing-protein	unknown	unknown	gnl|CDD|238657
NZ_CP043006.1|WP_148389963.1|3877612_3878317_-|DUF4918-family-protein	unknown	unknown	gnl|CDD|381690
NZ_CP043006.1|WP_148386928.1|3881543_3882071_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148386894.1|3870053_3870578_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148386904.1|3871942_3872746_-|DUF4249-family-protein	gnl|CDD|379442	pfam14054, DUF4249, Domain of unknown function (DUF4249). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 279 and 365 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.	2.37148e-28
NZ_CP043006.1|WP_148386946.1|3889318_3890557_+|phosphoglycerate-dehydrogenase	gnl|CDD|236985	PRK11790, PRK11790, phosphoglycerate dehydrogenase.	0
NZ_CP043006.1|WP_148386931.1|3882164_3883145_+|cation-diffusion-facilitator-family-transporter	gnl|CDD|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	1.18098e-67
NZ_CP043006.1|WP_148386943.1|3887861_3889076_-|serine-hydrolase	gnl|CDD|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.21108e-61
NZ_CP043006.1|WP_148389964.1|3883199_3883856_+|response-regulator	gnl|CDD|130454	TIGR01387, Transcriptional_regulatory_protein_PcoR, heavy metal response regulator. Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions].	7.35597e-75
NZ_CP043006.1|WP_148386939.1|3885237_3887640_-|FtsX-like-permease-family-protein	gnl|CDD|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	2.57072e-65
NZ_CP043006.1|WP_148386935.1|3883852_3885223_+|HAMP-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.05402e-51
NZ_CP043006.1|WP_148386911.1|3874903_3876841_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
NZ_CP043006.1|WP_148386924.1|3880548_3881349_+|translation-initiation-factor-IF-3	gnl|CDD|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	3.83533e-81
NZ_CP043006.1|WP_148386908.1|3872752_3874837_-|TonB-dependent-receptor-plug-domain-containing-protein	gnl|CDD|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	3.54962e-19
NZ_CP043006.1|WP_148386894.1|3870053_3870578_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.06331e-13
NZ_CP043006.1|WP_148389963.1|3877612_3878317_-|DUF4918-family-protein	gnl|CDD|381690	cd19375, UDG-F3-like_SMUG2, Uracil DNA glycosylase family 3-like subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 2 and similar proteins. Uracil DNA glycosylase family 3-like, which includes Pedobacter heparinus SMUG2, displays catalytic activities towards DNA containing uracil or hypoxanthine/xanthine. UDG catalyzes the removal of uracil from DNA to initiate the DNA base excision repair pathway. Uracil in DNA can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Uracil mispaired with guanine in DNA is one of the major pro-mutagenic events, causing G:C->A:T mutations. Thus, UDG is an essential enzyme for maintaining the integrity of genetic information. UDGs have been classified into various families on the basis of their substrate specificity, conserved motifs, and structural similarities. Although these families demonstrate different substrate specificities, often the function of one enzyme can be complemented by the other.	1.30041e-128
NZ_CP043006.1|WP_148386920.1|3878499_3880443_+|threonine--tRNA-ligase	gnl|CDD|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0

Protein sequences

>NZ_CP043006.1|WP_148386911.1|3874903_3876841_-|ATP-binding-cassette-domain-containing-protein
MLIALQDITFEFGARTIVEDSSWHIVPGDRVGLVGLNGTGKSTLLRIINGEYSISKGSLNKIRNLSIGFFNQDLLSFETDDSILNVGMTAFEQALKVEKELEILTEKLEHSQDEALLHEYSDKLHEFDTLDGYNIRHKTATVLEGLGFSTADLDRPYNQFSGGWRMRVLLARIILQQPDVLMLDEPTNHLDLPSIEWLEKYLSNYNGAVIIVSHDRFFLDRMVNKVVELYQQQLHHYAGNYSDFEEEKVQRRELQQRAYENQQDYIRQQEKFIERFKAKASKAAQAQSIAKRLDKLERVEQVDGGPSKIRMNFSVDRMPGKILSALEGVSKSFGNLHILKNASAEINRGDKIALIGANGKGKSTLLRVIAGTEPVEGNRVPGHNVVMSFYAQHQLEALHMDNEILEELKSCGSGKTEMELRSLLGCFLFQGDDVFKKIRILSGGEKARVALAKVIISQANFLLLDEPTNHLDMNSVEMLIDALGKYEGSLVLVSHDRYFVSRTANKIWEIVDGEIKEFKGTYTEWEEWKKRMAAQSQPPKAEKKSAAAARPAPVKNNNPIDKDLKKELQKQQRQFQQLEEKIAKLKTDVQQLEAQLGNPEIYGDRDRFRTAEEAYQQAGATLAKANEEYEAVFEKVMELEAKVQG
>NZ_CP043006.1|WP_148386908.1|3872752_3874837_-|TonB-dependent-receptor-plug-domain-containing-protein
MKTLLVTLACLFFTALYGQEKQPNDTASVIIANDTLKGITITHKVPRTLGMEHFSLKEMEHIPVFMGERDILKTIQLLPGIKSAGDGNSGFYVRGGSADQNLILLDGTPVYNASHLMGFFSTFNGDAIKDLAFYKNAMPAQYGGRLSAVVDASTNNGDDQEYHVSGGAGLIAARLNVEGPIVKNKSSFLLSGRRTYADLFTQLSNDSAIRNSNLNFYDLNLKVNFRVNERDELDLSAYTGHDIMRISNTFGLEWGNSVASLRWRHIFSNKLISYASLHYSSYENTTSALLSDQTASLHSRIRDYSAKAELLYTPDARRETRIGWQSTYHIMFPLLLEGGEGSGINQQQLSKRYSLDNTLYINNTWKATENLKLSYGLRATAFLVLGNGDFYDIDSDGKITDTLRSSAGQIVKTYFNLEPRIAAQYTLHKTGSLSFAFTRNVQHLHLVSNATSANPTDKWVASSNLIKPEIADQVSAGYSESIANDVFELSVETYYKALRNQIDYRNGAEVFSTEPTETMLLFGKGRAYGMEWLLKKKTGRLTGWIGYTLSRSERKIEGINNNEWYNAKQDRTHEFSVVTSLQLSKNWVLSANWVYHTGNAVTFPAGKYIVMDDRLVYYYTERNGYRMPAYHRLDVAATVQLNRSALHFGVYNAYGRENAYSIYFRESRENPDYTEAVQLTLFRFVPSVTYNFNF
>NZ_CP043006.1|WP_148386904.1|3871942_3872746_-|DUF4249-family-protein
MKKTFQLICIIAAAGLAASCEKVINAGLHPAEKKYVIEGIVTNEDTCRILLSMTSNFTDDNSFRGVSGALVQISDNGSGSITIPETRPGVYESLLVNGVPGHTYQLKVTVAGAVFTATSTMPSPVNFDTLFVSRINLAGRNRIVANAGYKDPSSVGNYYNFVQYINGAQRPDIYVNSDNLSNGRDVNFALYSPTELQEEGDIRPGDSLRVEMQCVDANVYKFWYSLNAGASGSDVLATPSNPVSNIAGGALGYFSAHAVQYLGMRVE
>NZ_CP043006.1|WP_148386901.1|3871152_3871917_-|hypothetical-protein
MFRFFRKSGAVKCPIPEENRLWVEEAFVWLLAEFGAEKIRSRKVLRPVPEDFPMQFDQSEKDAYALLPVIAAQMETEPGGISLGFYDQTLVEFPTGNGRMFSQQTPGEQYSAGTFQAGKKNGKYLISIEAAQLKSAENLVATLAHEIAHIKLLGEDRIKENDEHLTDLVPVIFGLGIFNANSSFNFYAGHDSWGYSKQGYLSQQEWGYALALFAYFRNEGEKPEWADYLVPNIRSDFRKAMAYISGNKDKILLK
>NZ_CP043006.1|WP_148386898.1|3870846_3871149_+|hypothetical-protein
MNYMRPALLGLFNVILFIAIQYFSLLSAFLFGMGAADYYRYERLVYIPGILLHLIVLIVLFIKHNRKTEWSLGYLISMLIVLILVIMTRTGIIPYHLIPS
>NZ_CP043006.1|WP_148386894.1|3870053_3870578_-|GNAT-family-N-acetyltransferase
MNSKFSMARLTTEPRIVTSLADLLIETVANGGSVSFMHPLSVEMATAFWESSLAAADCGKRVILGVFDENLLIGTVTLLLDSPPNQPHRAEIAKLMTRTSHRRQGVGRALMQAAERLAIDCCRTLLTLDTAEEDGAAGLYEELGFQKAGVIPDFALKPRGGLTGTIIYWKRIEK
>NZ_CP043006.1|WP_148386891.1|3869728_3869977_+|hypothetical-protein
MNREIFDERKADLINLIKVSLATTYTSEQDRTSLMRLLELLNQYSFENRLYQKGLLSHTIIDSLELDYSIGEKFIKFDNDIK
>NZ_CP043006.1|WP_148386887.1|3862153_3865132_+|hypothetical-protein
MYINALYAYSSSNSTKELIIFSTLKRCSGILLLVILAFTPVFGQHEDKVMVSLPSPNNLANALNQNVNVDFYKGQPQVNLPLYTLESAGLSVPVSLSYKASGIKLHDYASFVGMNWSLQAGGSIIRIVRGIPDEFANGYIGKNNTGAEINSEAHTPATRATKIANGEWDGEPDLFILTTPYESASFVFDENKIPVFTQPTKMTVTMLRPNGPDDFVNIHWQVVDERGTTFIFGNSTGSRETVDGATPYISAWYLNSMQSFNKTDEITFLYIAGSDITTYRYAKVKINYTNSCGSAPPPTIVENSNPVTYKAPKYLYQVIGKQGKIIFNYTADRLDLTSAYRLVSMDLYGGNSLLKRILLRHDYIRTPSSNSDLNRLSLKDIYIIGYDLSASMKLYGFKYYNNPLITFPARNSGSFDHWGYHNNNTAATPYPPEANKEPDLEKTKQFSLSEIEYGIGGKTLFEYELNMYFDDALQMNRYAGGLRVKSISEIDNEGKAFLKQFQYTTEDGKSSGQHFLRNFKYSKVTTNFIFPSNCTVSGEGVYNTVLFNQFDLTGVALGYSRVKVINPDGGSEIYRYHNFSDYPDDFSISNASLGTTYSIDNFRQFGYPTSYAYKRGLLYNKSLVNAAGNTVQETIYEYQSLAAEQRKARGVSITLEFTWVGGQRWYQTVYYHVRDIFRMVKETERTYSMENPSAFLTAEKSYSYSPDGTLLREVIHNTSKGLNYSQKYYYPANRDEINELASGEYAACGNMLNQVIPIREEKISYGGNKEIHHYSYGIITGVQQEPKTLLTGKQFSLNGSPFRQEMLYAYDLSTGFVESERSNDGVVKTYIYGPYSLLKAEITNAVKSEVFYENFESHHQSAGAGGAHTGAFYYPVLSYQINFVRPNQRSYKLSYNRRVNNKWEYIETNYTTDNLVLTESYPIDDVRVFPADAAMTTYTHYPLVGLSSKCGPNNELMYYDYDVFRRLKVVRDRYRNVLTRYDYKDACNCPLP
>NZ_CP043006.1|WP_148386883.1|3861178_3861673_+|hypothetical-protein
MSTTTSRHSELLYAIEFLRQNSANANIKLDYSPASVRQLDRMFDEAFAEGKLRNPESSFAKQQGLILTGVAGYLAEVVLRATEASELVIDPEGRDWYMRFRVVARNGWQLQPGMRVIRRVQEGREKDLYHYILTAIDYARRPEGGPGEIESLTLRGNRSWWKFW
>NZ_CP043006.1|WP_148386879.1|3860553_3861123_-|hypothetical-protein
MEAFPHIRIILGMILSLSLATLLKAAVKFIQHPHRVKPYWIHLLYAFFIFLELLLFWWWERKLAGILHWTFPAYFFTVCYILTFYGLASLLFPDDIKDYKGYEDYFFSRRKWFFGLLAITNLLDVADTLLKGLEYFYSLSYPYYLAVNGIDIALCIAGMRSSSRAFHGFLIIWFILFKLIDIGRIYFYW
>NZ_CP043006.1|WP_148389963.1|3877612_3878317_-|DUF4918-family-protein
MQTTADKIIHFNDHLEFTGQLPPGIRIMNPFREQDGVSAIMQQFYRKFYSDQRRRQMIVGINPGRFGGGVTGIPFTDSQRLADPCGIVIPGIRTYEPSSVYVYDVIAAYGGPERFYGDFYIAAMSPLGFTALKPGGKEVNYNYYDSKALTEAVYDFMVSSLRKQLQFGIDRSVGYCLGTGKNADFLIRLNEKEKFFDRVVPLEHPRFIMQYRNKRKQEYIDKYLTAFSDHPVER
>NZ_CP043006.1|WP_148386920.1|3878499_3880443_+|threonine--tRNA-ligase
MINITFPDGAVRQYEQGVSALDIAKSISEGLARKVLAAKVNGQVVDASRPITTDGTLQLLTWTDADGKATMWHSSAHLMAEALEALYPGVKFGYGPSLENGGFFYDVDLDGRQISDEELRKLEVKMAELAKQNNAYLRREISKADAIQYFTDKKDPYKLDLLQKLEDGSITFYTQGNFTDLCRGPHIPSTGFIKAIRLTNIAGAYWLGNENNKMLTRIYGITFPSQKELDEYLTLIEEAKKRDHRKLGKELELFAFSEKVGLGLPLWLPKGAMLRERLQAFLQKAQLESGYLPVITPHIGNKNLYITSGHYEKYGKDSFQPIHTPEEGEEFMLKPMNCPHHCEIYKTSPKSYKDLPVRFAEFGTVYRYEQHGELHGLTRVRGFTQDDAHLFCRPDQVKEEFCKVIDLVLYVFNSLSFTDFTAQISLRDQEDRTKYIGSDENWNLAEQAIIESAAEKGLRTVIEYGEAAFYGPKLDFMVKDALGRKWQLGTIQVDYNLPERFELEYIGADNKPHRPVMIHRAPFGSLERFIAVLIEHCAGKFPLWLTPTQVKILPISDKFLPYSEKVAELLKKAEIRAEIDDRSEKIGKKIREAEMAKVPYMLVVGEKEEADGKVAVRRQAKGDLGAMSTDEFMKLVQDEVVNRKPFE
>NZ_CP043006.1|WP_148386924.1|3880548_3881349_+|translation-initiation-factor-IF-3
MQQGPRPNFNRGRNPNFRREQQQEHRTNRMIRVPEVRLVGDNVEPGVYRTEEALRMAEDLALDLVEISPNAAPPVCRIIDYNKFLYEKKKKEKEMKANAHKSEVKEIRFTPNTDDHDFDFKAKHAEKFLKEGNKVKTYVQFKGRAIMFKERGELILLKFAERLSEVGALEGMPTMEGKRMIAIFAPKSAKKKPAKEPKEPRDPAAAGAADQAPREPREPREPRPQPPAGAPPVRRPIEIKYANRPPAAPATQDKPADKPADNNSGN
>NZ_CP043006.1|WP_148386928.1|3881543_3882071_-|hypothetical-protein
MQLREEILKEHSKAHSLSIARWIGNNPARLDQLVQLFLFDEYRVVQRAAWIMSLVAEAHPLLLKPHLPAMVDRMGDDNIPVAVKRNVVRVLQHMDIPEDLQGPVMNYCFRFLEDPAETVAVRAFSMTVLARLAKQYPDIKQEIVLLIEDQLREGATAGFISRGKRTLKELGKIKG
>NZ_CP043006.1|WP_148386931.1|3882164_3883145_+|cation-diffusion-facilitator-family-transporter
MVRKEFRIILLSLGISLLLTAAKFTAYFVTNSVAILSDALESIINVVAGGFACYSIYLSGKPKDANHPYGHGKVEFFSIGFEGAMIFIAGCLILFKAVQYFIHQPALEEVDQGIWITVATSAANFLLGLYLVRSGKKLPSITITGNGQHILTDAYTSVGLIVALVLIRLTGKTWIDPAASVIMGILILRKGYQLMRQSISGLMDETDMQVMDRVIGILNEHRHPAWIDVHNMRVQQYGIDYHIDCHVTMPYYLELSRAHEEMKELEQLVDRELKGHEVEFFIHIDPCIPESCQHCQLSACPVRSYPFRQRISWSRENVLPNRKHTD
>NZ_CP043006.1|WP_148389964.1|3883199_3883856_+|response-regulator
MKVANAVKMGLEENGFSVALAYDGRRGKELAASGDYDLVILDLNLPGHTGYEICEVIRQRNARVPVIMLTARVGMDDKMRAFELGADDYLVKPFDFRELLARIRVFLKRAGAETIPDNRYRIMIADLEINRERKEVLRSGKKIPLTAKEYQLLELLALHSGKVISKAVIAEKVWNIDFDTGTNVIEVYMNFLRKKIDKDFDHKLLHTKTGMGYYLSGE
>NZ_CP043006.1|WP_148386935.1|3883852_3885223_+|HAMP-domain-containing-protein
MKIKYKIALYYTLSAAFLLVAFAVLAYYFSGRTRHEEYLGRLEYRAMSIGAVIIENDEVQIGLLRKLDKTTFQDLYEETIQVYDDHYNLLYSNMKDAALHAPRALLERIKTSKRYVRRDDSGETAGVYYTEDNMSVLVIVSSFDKYGFQNLRNLQRILVIELLVAVVLLVVIGYFFARKMVEPVERLVEQADKINASNLQDERVAIKGKDEIAQLGANFNTMLQRLSHSFDQQKSFVGNASHELRTPLAAIISQLQVTLAKRRSGEEYEAVLQSVLEDAEGLSELTNGLLQLAQPDMNSRELTFSPIRVDEMLLEAGDFIRLKRKTGSKVDIQFVREPEQDTSIICQGNESLLKVLFINLVDNACKFSEDNAAQVSIDFDSRHILVHIRNNGPAIPEDELNRIFEPFYRGRNSRHQRGHGLGLSICRKIVQWHGGELRVQATGVAGTIFTVQLPHV
>NZ_CP043006.1|WP_148386939.1|3885237_3887640_-|FtsX-like-permease-family-protein
MFSNYLKTASRSLWRNKRYSIINITGLTLGIAVCLVIFVIIRYEKSFDGFHAKKDRIFRVLTVSNKPGGDYSYTEAVPFPLPTALHNDFPDMEEISGVASFGERLVSVADSKGNTYKKFKPRIFFLEPSFFRIFDFTWLAGDKSTALNDPNSIVLSRSVAEKYFGDWRKAMGKTLRLDQLFSLTVTGVLDDPPSNSEFQLQVVVPYSHPKFGQSKDWVSLDDIHHCYVLLRPGQTAAQIDRRLVSFSKKYKAADNESTHKLQPLARVHTDTATSNFMGRVVSVERIRALWLIAVFILLIACMNFINLSTAQAVNRAREIGVRKVLGSRRWQLQLQFLTETCILVFTSLLLAVTIASFILRFIGLVMELPLHPQMLLNIPVFLLLAAILVMVTFLAGGYPSMVLAGFNPVNALKSKVAASRSKAGISLRRGLVVFQFIIAQALIIGTLIILQQLNYFRNQPLGFSPNAMVNVPFRNDSAGNSKIGYLRDQLKMIKGVEQVSFSNSTPSEAGSWWTPFNFDHAEKHTDFAAISKWVDADFVDTYGLQLLAGRSLTRTDSVREFIVNETLVKKLGLARPEDILYKEIDVWNGFAKGPVVGVVRDFHTGPLKDAIGPVFMCNVRQRLNSAGVRLSGSDLQASIKAIEKLWTENFPEQIFEYQFLDDKISSFYKEEQQLAQLYKIFAGIAIFLSCLGLYGLASFMAVQRLREVGVRKVLGATASNIVLLFSKEFMVLIGIAFVLATPLVWYFMRQWLQHYVYRIDIGWGVFLAGGIASMAVALVTVSFQAVKAAMTNPVKSLKAD
>NZ_CP043006.1|WP_148386943.1|3887861_3889076_-|serine-hydrolase
MNRLKAVVCTAFIISASAVVHTGCNSSSAHRNTEKKAPKPVSPYTLGLSEEEEKAISGSAYAERVRQEVAEMMRHRLSPRTFSGALLIAKKGVILYEKYQGEENHATKTPVTDSSSFQLASISKTFTGMAVLSLVEKGKLGLDDPLQKFFPDFPYLGITVSMLLNHRSGLPNYLYFCDSLIKDRSIFLTNEEVIRLMTEHKPPAQYQPDRHFNYCNTNYLLLATIIEKASGQKYADYLQQTFFTPLEMTGTFVMDPAQAPRPHQTISHLFSWKAEPDNAFDGVTGDKGIYSTARDMLKWDQAIYSGNLFKPETLKAAFTPYSHEKPGIRNYGFGWRLMAYPDSTKNIVYHNGWWHGNNTVFYRFVEDSTTLIILGNRYNRGIYQAVRPLRAILGHGDSEEAGEE
>NZ_CP043006.1|WP_148386946.1|3889318_3890557_+|phosphoglycerate-dehydrogenase
MSQKKLTSYPKEKINILLLENISDAAVAEFKDAGYANTRKVTGALSEQDLIKEVKDAHLLGIRSKTQITPAVLAAAKKLQAIGCFCIGTNQVDLKTATELGVAVFNAPYSNTRSVAELVIGLSIMLIRRIPDKNTAAHKGVWMKEATGSYELRGKTLAIVGYGNIGSQVSVLAEAMGMNVIYYDVETKLPLGNATQIRTIKDLFSQADIISLHVPSNKSTVNMINKETLKHVKEGAIFINYARGEVVELDDLKEALQSGRLSGAAIDVFPVEPEKNGAAFSTPLQNLPNVILTPHIGGSTEEAQHNIGLDVSEKMLNYLEKGASFGSHTIPALSLPAVENTHRILHIHRNVPGVLSEINSTLSSKNINILGQYLKTNDQIGYVVLDVDSKLSQEAFALLKEVNHTIKTRMLY

Crispr_ID: NZ_CP043006_9

• CRISPR_ID: NZ_CP043006_9
• CRISPR_location: 4381620-4381715
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_9

Consensus_repeat	Method
TGCATGGTGCATCCTCTCTTTTATTGCAG	CRISPRCasFinder

spacers of NZ_CP043006_9

>9.1|4381649|38|NZ_CP043006|CRISPRCasFinder
GTATATAACATCGGAACAAACATATCCATGGAGCTGTA

CRISPR arrays and Neighbor proteins around NZ_CP043006_9

CRISPR arrays

The CRISPR arrays of NZ_CP043006_9

>merge|NZ_CP043006|9|4381620-4381715|CRISPRCasFinder
TGCATGGTGCATCCTCTCTTTTATTGCAGGTATATAACATCGGAACAAACATATCCATGGAGCTGTATGCATGGTGCATCCTCTCTTCTATTGCAG

>NZ_CP043006|9|7|4381620-4381715|CRISPRCasFinder
TGCATGGTGCATCCTCTCTTTTATTGCAG	GTATATAACATCGGAACAAACATATCCATGGAGCTGTA
TGCATGGTGCATCCTCTCTTCTATTGCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148387774.1|4380514_4381582_+|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl|CDD|236406
NZ_CP043006.1|WP_148387770.1|4378962_4379742_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238564
NZ_CP043006.1|WP_148387761.1|4375124_4376198_-|tetraacyldisaccharide-4'-kinase	unknown	unknown	gnl|CDD|376853
NZ_CP043006.1|WP_148387759.1|4373014_4375087_-|ribonuclease-R	unknown	unknown	gnl|CDD|273947
NZ_CP043006.1|WP_148387756.1|4372029_4373001_-|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|376322
NZ_CP043006.1|WP_168208870.1|4391956_4393627_+|glycoside-hydrolase-family-32-protein	unknown	unknown	gnl|CDD|350134
NZ_CP043006.1|WP_148387777.1|4381763_4384556_-|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380531
NZ_CP043006.1|WP_168208869.1|4376324_4376897_-|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl|CDD|274270
NZ_CP043006.1|WP_148387779.1|4384828_4386154_+|sugar-porter-family-MFS-transporter	unknown	unknown	gnl|CDD|340917
NZ_CP043006.1|WP_148387782.1|4387096_4390174_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148387765.1|4376896_4377538_-|dethiobiotin-synthase	unknown	unknown	gnl|CDD|234625
NZ_CP043006.1|WP_148387790.1|4394662_4395103_+|SsrA-binding-protein-SmpB	unknown	unknown	gnl|CDD|376590
NZ_CP043006.1|WP_148389981.1|4386189_4387071_+|carbohydrate-kinase	unknown	unknown	gnl|CDD|238572
NZ_CP043006.1|WP_148387792.1|4395260_4396379_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148387767.1|4377601_4378960_+|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|273464
NZ_CP043006.1|WP_148387754.1|4370485_4371841_-|voltage-gated-chloride-channel-family-protein	unknown	unknown	gnl|CDD|239654
NZ_CP043006.1|WP_148387788.1|4393785_4394631_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	unknown	unknown	gnl|CDD|235547
NZ_CP043006.1|WP_148387784.1|4390202_4391921_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
NZ_CP043006.1|WP_148387772.1|4379878_4380334_+|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|239550
NZ_CP043006.1|WP_148387794.1|4396424_4396850_+|META-domain-containing-protein	unknown	unknown	gnl|CDD|377111

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148387774.1|4380514_4381582_+|class-II-fructose-bisphosphate-aldolase	gnl|CDD|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NZ_CP043006.1|WP_148387770.1|4378962_4379742_+|ABC-transporter-substrate-binding-protein	gnl|CDD|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	5.46581e-42
NZ_CP043006.1|WP_148387761.1|4375124_4376198_-|tetraacyldisaccharide-4'-kinase	gnl|CDD|376853	pfam02606, LpxK, Tetraacyldisaccharide-1-P 4'-kinase. This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N-terminus.	7.42344e-88
NZ_CP043006.1|WP_148387759.1|4373014_4375087_-|ribonuclease-R	gnl|CDD|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NZ_CP043006.1|WP_148387756.1|4372029_4373001_-|polyprenyl-synthetase-family-protein	gnl|CDD|376322	pfam00348, polyprenyl_synt, Polyprenyl synthetase.	7.06005e-91
NZ_CP043006.1|WP_168208870.1|4391956_4393627_+|glycoside-hydrolase-family-32-protein	gnl|CDD|350134	cd18622, GH32_Inu-like, glycoside hydrolase family 32 protein such as Aspergillus ficuum endo-inulinase (Inu2). This subfamily of glycosyl hydrolase family GH32 includes endo-inulinase (inu2, EC 3.2.1.7), exo-inulinase (Inu1, EC 3.2.1.80), invertase (EC 3.2.1.26), and levan fructotransferase (LftA, EC 4.2.2.16), among others. These enzymes cleave sucrose into fructose and glucose via beta-fructofuranosidase activity, producing invert sugar that is a mixture of dextrorotatory D-glucose and levorotatory D-fructose, thus named invertase (EC 3.2.1.26). These retaining enzymes (i.e. they retain the configuration at anomeric carbon atom of the substrate) catalyze hydrolysis in two steps involving a covalent glycosyl enzyme intermediate: an aspartate located close to the N-terminus acts as the catalytic nucleophile and a glutamate acts as the general acid/base; a conserved aspartate residue in the Arg-Asp-Pro (RDP) motif stabilizes the transition state. These enzymes are predicted to display a 5-fold beta-propeller fold as found for GH43 and CH68. The breakdown of sucrose is widely used as a carbon or energy source by bacteria, fungi, and plants. Invertase is used commercially in the confectionery industry, since fructose has a sweeter taste than sucrose and a lower tendency to crystallize. A common structural feature of all these enzymes is a 5-bladed beta-propeller domain, similar to GH43, that contains the catalytic acid and catalytic base. A long V-shaped groove, partially enclosed at one end, forms a single extended substrate-binding surface across the face of the propeller.	3.75596e-123
NZ_CP043006.1|WP_148387777.1|4381763_4384556_-|substrate-binding-domain-containing-protein	gnl|CDD|380531	cd06308, PBP1_sensor_kinase-like, periplasmic binding domain of two-component sensor kinase signaling systems. Periplasmic binding domain of two-component sensor kinase signaling systems, some of which are fused with a C-terminal histidine kinase A domain (HisK) and/or a signal receiver domain (REC). Members of this group share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily and are predicted to be involved in sensing of environmental stimuli; their substrate specificities, however, are not known in detail.	4.48772e-117
NZ_CP043006.1|WP_168208869.1|4376324_4376897_-|5-formyltetrahydrofolate-cyclo-ligase	gnl|CDD|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	7.00417e-36
NZ_CP043006.1|WP_148387779.1|4384828_4386154_+|sugar-porter-family-MFS-transporter	gnl|CDD|340917	cd17359, MFS_XylE_like, D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily. This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.7414e-135
NZ_CP043006.1|WP_148387782.1|4387096_4390174_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_148387765.1|4376896_4377538_-|dethiobiotin-synthase	gnl|CDD|234625	PRK00090, bioD, ATP-dependent dethiobiotin synthetase BioD.	9.38767e-58
NZ_CP043006.1|WP_148387790.1|4394662_4395103_+|SsrA-binding-protein-SmpB	gnl|CDD|376590	pfam01668, SmpB, SmpB protein.	1.48336e-72
NZ_CP043006.1|WP_148389981.1|4386189_4387071_+|carbohydrate-kinase	gnl|CDD|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	5.61908e-76
NZ_CP043006.1|WP_148387767.1|4377601_4378960_+|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	2.08271e-155
NZ_CP043006.1|WP_148387754.1|4370485_4371841_-|voltage-gated-chloride-channel-family-protein	gnl|CDD|239654	cd03682, ClC_sycA_like, ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation competitiveness, and N2 fixation on Phaseolus vulgaris plants, due to its reduced ability for acid resistance. This family is part of the ClC chloride channel superfamiy. These proteins catalyse the selective flow of Cl- ions across cell membranes and Cl-/H+ exchange transport. These proteins share two characteristics that are apparently inherent to the entire ClC chloride channel superfamily: a unique double-barreled architecture and voltage-dependent gating mechanism. The gating is conferred by the permeating anion itself, acting as the gating charge.	0
NZ_CP043006.1|WP_148387788.1|4393785_4394631_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta	gnl|CDD|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	4.47078e-160
NZ_CP043006.1|WP_148387784.1|4390202_4391921_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	8.64442e-31
NZ_CP043006.1|WP_148387772.1|4379878_4380334_+|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|239550	cd03467, Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. The Rieske domain can be divided into two subdomains, with an incomplete six-stranded, antiparallel beta-barrel at one end, and an iron-sulfur cluster binding subdomain at the other. The Rieske iron-sulfur center contains a [2Fe-2S] cluster, which is involved in electron transfer, and is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In RO systems, the N-terminal Rieske domain of the alpha subunit acts as an electron shuttle that accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron in the alpha subunit C-terminal domain to be used for catalysis.	1.17429e-12
NZ_CP043006.1|WP_148387794.1|4396424_4396850_+|META-domain-containing-protein	gnl|CDD|377111	pfam03724, META, META domain. Small domain family found in proteins of of unknown function. Some are secreted and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence. A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	5.96084e-26

Protein sequences

>NZ_CP043006.1|WP_148387774.1|4380514_4381582_+|class-II-fructose-bisphosphate-aldolase
MGKYKAGVLFGEELEALYNDAKENEFAMPAVNVVGTDSANAVLETAAKVNSPVIIQFSNGGAQFFAGKGMPNDKLQANISGGISGAKHIHEVAKYYGVPVILHTDHAAKKWLPWIDGLLDAGETFMKEKGQPLYSSHMLDLSEEPIHENIATSKAYFERMNKLGMSIEIELGVTGGEEDGVDNSGVENSLLYTQPEDVAYAYEQLSQVSSRFTVAAAFGNVHGVYSPGNVELRPEILKNSQEFIEQKFGTAKKPVYYVFHGGSGSPKNQINETLGYGVIKMNIDTDMQWAFWEGVLKYYKKNEAYLQAQLGNPEGENKPNKKYYDPRVWLRKGEETFVERLTEAFNDLNCINRNA
>NZ_CP043006.1|WP_148387772.1|4379878_4380334_+|Rieske-2Fe-2S-domain-containing-protein
MERRDFLSNMGITLVIACAGGIAACSKGGDTPEPAPNPNPNPNPNPGGARLTVNLNSQIPNIGDYIISSGVVLIRLAAGNVPASFSALTSTCTHEGCTLSNYASATQKIECGSSCGHGSRFNTDGTVSNGPATGALTKYTVEISGTTLTVK
>NZ_CP043006.1|WP_148387770.1|4378962_4379742_+|ABC-transporter-substrate-binding-protein
MLFTDQLGRSVEIPSPPRRIVSVVPSQTELLYDLGVSVTGITKFCVHPESWFRSITRIGGTKQLNIEKIISLQPDLIIANKEENEKAQIEALAAKFPVWISDIQNLGDACNMILSLGNILQKTSEALSITSRIKEGFARLQPPSLAIPAAYFIWRNPWMIAGGDTFIHEMMHACGFRNVFEDMPRYPVISLAQLAASGCRLVLLSSEPYPFCEKHIAEVREYLPDADIRLVDGEMFSWYGSRLLHAPEYFRELMVSLQH
>NZ_CP043006.1|WP_148387767.1|4377601_4378960_+|pyridoxal-phosphate-dependent-enzyme
MKYCENILETIGHTPLVKLHRVTAELPCTVLAKVEFFNPGNSIKDRMAIKMVEEAEKQGLLKPGGTIIEGTSGNTGMGLALAAVIKGYKCIFTTTDKQSKEKVDILKAVGAEVIVCPTNVLPEDPKSYYSVSRRLSKEVPNSFYVNQYDNLANRDAHYEQTGPEIWEQTDGKVTHLVVATGTGGTITGTGRYLKEKNPAIQVWAIDSYGSLLKKFHETGELDMNEVYPYITEGIGEDFVPQNYDMSVIDHFEKVTDKDGAVMARRIAKEEGIFVGYSAGSAIAGLQQLKSRLKPEDVVVVVFHDHGSRYVGKVYNDQWMMERGFLDVKTVKDIVNSRRNLPLVTIAPEETVSGAIAKMKKFDIEHLPVTANGEYIGAISEGGLFSKLIDQPELKEAPVKAVMHKTFPLVSMDTPIEKLTMYINKENGAVLTQDESGNAHIVTKYDIIQALGS
>NZ_CP043006.1|WP_148387765.1|4376896_4377538_-|dethiobiotin-synthase
MNNIFITGIGTGVGKTIASACVTEALGANYWKPVQAGLQDATDTQTVRSLLSDGSHVRDELYRLRMPASPHLAAAREGITLQEDKIVQRAKELQQPDVPLVIEGAGGLMVPLGKKVFMIDLIRALEARVIIVAQNYLGSINHCLLTAMALKQAAVPVVGWIFSGDHHTNEDDIVSWSQYPRIARIPRVRRVTREFVTMQAELLQPALLQCLSA
>NZ_CP043006.1|WP_168208869.1|4376324_4376897_-|5-formyltetrahydrofolate-cyclo-ligase
MVTKKDIRKAYLAKRQSLPEETAAELNAALLEQCRQLPLEDVNVAHLFLPIMAKKEIDTWPLADWLRERYPGMQLVLSRSYLATGNMQHYLWEAGTSLVHNSLGIPEPESGRLVAPEEIDLVFVPMLAFDEQGHRVGYGKGMYDTFLRQCRANVRKIGLCLFPPLPAIEDVYAGDVPLDMVVTPQRTWYF
>NZ_CP043006.1|WP_148387761.1|4375124_4376198_-|tetraacyldisaccharide-4'-kinase
MWRYLNYLLYPFSLLYGLVLWIRNRLYDNGMLTAVEFDLPVIAVGNLSVGGTGKTPHVEYLIRLLKAAYRVATLSRGYNRRTRGFLLAKADSTSADIGDEPMQFHQKFPDITVCVGEERMLAVPQLLGDRPETQVILLDDAFQHRSIKPGLNLMVTDYSRLFTRDHVVPFGRLREGRNGYYRADGIIVSKCPPELSTQEQEAIYREIAPYPHQRLFFTCLQYGQPYGMLQPDMAPPPPGASILVVCGIARPEPLVHHLLQHYANVHLLSFPDHYYYTQQDLDKIKMELDHMDGGAKHIITTEKDAVRLHLLKDSIAAMQLPIAVMPVEVRFLFDGADSFNSYIFDYVADAMLAAENE
>NZ_CP043006.1|WP_148387759.1|4373014_4375087_-|ribonuclease-R
MTKKKKPKKDSSQKKTYKGIVDITRSGMAYVAVEGLASDIIVKQKNLNTALDGDEVLVNVIPPARRTARMEGFVADVLKRRKTEFTGTIQLNKNFAFLVPEKGAFVPDIYIPENSLKEAKDGDKAVVKIVAWGEKSRKPVGEIVEILDATDTNDLAMKEILIESGFPLHFPEDVMTELAAIKEKITAAEIKKRKDFRKILTFTIDPVDAKDFDDALSIRKLKNGLYEVGVHIADVSHYVLPATALDKEAEKRATSVYLPDRVLPMLPEKISNELCSLRPHEDKLTFSAVFQMNEQAEVKQFWLGRTVIHSAHRFTYEEVQEVIEAGEGPYDQEVLLLNKMAQTMRSKRFSEGAINFSSQEVRFQLDASGKPIGVTIKESKEAHQLIEEFMLLANRTVAEYASKQRVNKQPVPFPYRVHNTPDEEKMHVFAVFANKFGYKFDVNTPESIARSFNTMLQLVQGKPEQHVLETLGIRTMAKAVYTTENIGHYGLGFMHYSHFTSPIRRYPDVLVHRILAQCLADEVKIDKLLENRCKHSSDMERKAMEAERAGNKYKQVEYMQQFLGEEFEGVVSGVAHFGFWVETVDAKCEGLVSLHNLAEDFIHSESEYALIGQQTGKKYRIGDKVMIRVVAANLAKRQLDYDLVDGGAADGSVPRRASAARPSKPASRTGTRSRGSAPEHRGKPKTRKKK
>NZ_CP043006.1|WP_148387756.1|4372029_4373001_-|polyprenyl-synthetase-family-protein
MHSFKALSEKFEQQFGKRQFPDFPANLYDPAQYILGIGGKRIRPVLTLLGNELFDEIHPDAYHAANAVELFHNFTLIHDDIMDKAPLRRGNPTVHTKYSDSAAILAGDVMLIHCYDYLNKIQLRLQHKITAVFNKAAREVCEGQQLDMDLEQMSPEQVNYADYVNMIALKTSVLLAGSLQMGAIIGGGSEGNQGHLYEFGKNVGIAFQIQDDYLDAFGDPEKFGKQQGGDILINKKTFLLLKALELCTPAQKKHLHELMERNPENKIAEVLQVFHDCKVDTWAEKEKERFCNAAFEHLDDIAVLSKRKEPLRELADYLLTRQH
>NZ_CP043006.1|WP_148387754.1|4370485_4371841_-|voltage-gated-chloride-channel-family-protein
MNRLKNSFEQFFIASHLLKWTLLVLPVAITAGSLVALFLWLLDEAINLRFVHPWLLYFLPLAGIFIYLLYRYTGKNSEGGNNLIMDEIHQPGGGIPVRMAPLVLFTTVITHLFGGSAGREGTAVQIGGSMAQFFAKKLKLAPEDVKLLLMTGIAAGFGAVFGTPVTGAIFALEVIALGRIRHNALLPCLMASVLADITCSAWGAHHTHYQIGKLLEGEMLFSFLHFDLLLLLKVVIAGVCFGLASYMFAELSHTIKDYSNKWIKVKWMVPATGGLIVIALTWLTGTQDYLSLGVSNPDPAAVSILSSFREGGAGTFSWFWKLLFTAVTLGMGFKGGEVTPLFFIGAALGNTLAVLGGAPVDLMAGLGFIAVFAGATNTPIACTIMGVELFGADNLLYYAIACFTAYYFSGHSGIYSAQRIAVPKADRPGAEPDTTLRETRAARIRKFRFKR
>NZ_CP043006.1|WP_148387777.1|4381763_4384556_-|substrate-binding-domain-containing-protein
MSASRCIPHFLSRTVLVVLILSAFAAGCGQPAKIRHFRIGFSQCGDADHWRKSMLAEMQRELSFHPDIELIYKQADDNSQLQIRQVKELLAEGIDLLIISPNEASPLTPVVEEVYNQGIPVIVVDRKIASTSYTNYIGADNYEIGRIAGEYVAALLKGKGKVIEVIGLPASSPAIERKRGFSDGISRHPGIRLLEQVHGDWVMQKSESALGNTGNLLREADLVFAHNDVMALGARHAAIRAGAHDMKIIGVDALPGKGAGLEMVSGKQLNASLLYPTGGTEAIRNAISIMNKALLPKETFLQTLVVDSTNVRMMQLQSDKIFNQQKDIELQQGMIAEQLRVYKSQRTMLYVLGITLCAAVFFAGLLWYSRNLNKQINRKLALQNEEISRQSRQLMEMSAAAAEANEARISFFTNISHEIRTPLTLITGPLDEMLQHSRLQGGDRQQLSLVRRNANRLLHLVNQLMDFRKLEFSKMQVRASENDLVLFCHEIVEIFQQTARKRGMDCRLVTSERSLPVWMDSGMMDKVLFNLMSNAFKFTPDQGAVLIKLEKRGGEAVIQVQDTGIGMSAEVMQHAFDTFYQGDVNNHKGSGLGLALCKELVQLHHGSITASSGKNRGTIFTVTIPLGKDHFRPEELSGSSAREEPQFYTADLLPVPDEQLEPVAGNRRFVILLVEDNPELRSFIRLRLSHDYEVLEAENGQQGLQMAFEYLPDGIICDVMMPVKDGHALLKEIKADVRTAHIPVVLLTARVTPDQQVEGLQNKADAYIVKPFDFKILQHTLNSLMANRSHLKEHFTADVPAGLRSAVSRKTELRFVSEFTSIVENNIGNEDFSIEDIYRQMNISKVQLYRKVKALMGTNINEYILNTRLQKARYCLQHEDISVAEVAYKTGFSSPAYFSTVFKSKLGVSPTAYKGKKKDNGTGNDKAEWT
>NZ_CP043006.1|WP_148387779.1|4384828_4386154_+|sugar-porter-family-MFS-transporter
MNSKVFFWSITVALGGFLFGFDTAVISGAEQSIQRYWQLDGFQHGLTVSIALIGTIIGSMFGSIPSERLGRKKTLIGIAVLYLFSSFGTALATDWYVFLVFRFLGGVGVGASSVTAPVYISEISPAASRGKLVALFQFNIVFGILVSYLSNYLIGQEGESSWRWMLGVQAAPSLLFLVLLRFVPESPRWLMIRKGDFAQAERIFRVINPSGFEKEMQMIRQDISTHGASGQETLFSRKNRFPVFLAIVFAVFNQVSGINAIIYYAPRIFEMTGLGKQSALLSSVGIGFVNFIFTLLALNFIDRFGRRTLMLIGSLGLIVTLGLVSRAFYLDDFSGLAVTIFLLVYIAFFAFSQGAVIWVFISEIFPNQVRAKGQTLGSMTHWIMAAVIAFAFPMLTENLGGGNTFLFFCIMMVLQLIFVWKIMPETKGKSLEQLEGTLVMH
>NZ_CP043006.1|WP_148389981.1|4386189_4387071_+|carbohydrate-kinase
MPRHSIVCYGEVLWDLLPSGPQPGGAPMNVAYHLHKLHCHPAMISRVGNDDRGRELLEYLRGKGVCTDYIQIDDTVPTGIVNAQQQANGDMTYDIVFPAAWDHIVADDINIRLVEQAEYFVFGSLACRHPASRNTLFSLLKKARTKVLDINLRAPFYDQELISQLLAEADILKLNSDELELVSNWYAAPADTTARLAFLREKFRIPVIILTMGANGAILDMGGKTYTHPGYRTTVVDTVGSGDAFLAATLSMMPGNARPEEILDFANRLAATITTYKGACPDYDTTAADALKA
>NZ_CP043006.1|WP_148387782.1|4387096_4390174_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKYCLTIFAILLTGLTSLAQQKKVTGTVTEKSTGTPLPGVSVQATGSTVISDSAGHFSIPAAVNEVLTFTYIGMKPAMVKVPASGNIQVAMDKDASDLNEVVVTGYQAQKKADLTGAVSVVDVEAIRDVPLGNPVKALQGRVPGVFITSDGSPSGGATVRIRGVGTLGNNDPLYVIDGVPTKRGLQELNQDDIASIQVLKDASSATIYGSRAANGVIIVTTKRAQKGFTRVDFDASTSLQYYAAKQKTLDADGRGKAYWQAAVNDRSNPNNNQIYQYDWNGDYDNPVLNSIIYPDFIDAAETMRPANTYWYDEIAQTSVIQQYNLSVSTGGERGSSLFSLGYYDNKGVVRTSNNKKITARLNSDYSFFKNKLKVGENLNFSYIRNTLIPIGDILFTSLVQQPIVPVHSVDGGWGGPAPGMTDRHNPVRLIEDNQQNRNHFYRIFGNVYAELDIIPGLHFRTSLGIDYNGNYQRTLRKSYVSGFLSDPSNQTSTNQGYDGNWLWQNTLNYKLDRGQHRFELLAGHEQIRYMSQSFFASRQGYALENIDYAYIDAGSSNKDNGGNGSGYALLSFFGKVNYAYADRYLASVTLRRDGSSRFGREYRYGMFPAFSAGWRISEEAFMKDLSVISDLKFRYGWGRSGNQEINNNATYGLYASIYGIDPTWAFDNGSAYDINGSGSGQLPSGFTRIQQGNDSLKWEGTKESNFGIDFGLFGNKLTGSVDYFVKQTSDILISPGYLAVQGEGGNYWFNGASMENKGLEALLSYSGNISRGLAFTVTGNFSTYRNKVTYLPDQVLTSYPGNGTDKTILGRSINSSFGYIADGLFTTQKEVDESPAQTGKGLGRIRYRDLNGDNIIDDRDRDYIADGNPDFIYGLNVELSWKNFDLSFFLQGVQGIQVYNDFKTFTDFSSLWVGSNWGERTLDAWTPANSSSTIPALTLVNRNNEGRASTYFYEDGSYLKLRNIQLGYNLRHALRNTPIQNARVFLQGSNLLTIKSKGFTAADPEAPGHSFPIPAIVTAGFNISL
>NZ_CP043006.1|WP_148387784.1|4390202_4391921_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKNLVILLLITFLFTPSCKDVLDQTPQGVVSDDDLNTPENIDKMVIAAYSALGNDHYTSPYTSLWAYGSIRGGDAYKGGDGPGDLSEFHLLETFSLNRVDNGLTDELWFRLYVGVGRVNDALRRLNAIDPASYPQRETRQGEMRFLRGHFYFLLKILFKYTPYIDENAERTAYDTISNRALSNDALWTKIADDFRAAVAQLPPSQPEIGRASQSSAKAYLAKTLLYQAYEQNEKNEVTAINTAKLEEVNKLCDEIITTQKYRLNDDYGDNFLTQSENSRESVFAIQYSKDDGTPKGRLDYGHALNYPMNQEFGCCGFHVPSHDLINSFKTDANGLPMFDHYNDVDVAESGDYQTGTFDPRLDHTVAIPGKPFKYDPLFVFQRSWARAPEVYDAFASLKEAVSPDDPSFQKIPPFMSSSKNWDIIRFSDVMLFKAEALIELGRHLEALPLINDLRTRSANSTARLRKADDTPVSNYSVATYQPGVNCTWTQPFARQALRWERRLELATEGYHFFDLVRWGIAAEYINHYFTIEKNRSAHLSDAAFRKNRDEYLPVPLNQINYSRGLYKQNNGW
>NZ_CP043006.1|WP_168208870.1|4391956_4393627_+|glycoside-hydrolase-family-32-protein
MKTIWTGILCLCLLVQAASAQQFSSTFKASKKWLVLPVKNGAPKKNVELWIDGEHERWFDIELADGEPDWLAYLDISAWKGMDIELRVDKLGKDSKAFSPIRQSDEDRNEGELYKEKLRGQFHFSPKRGWTNDPNGMVYYNGEYHLFFQHNPYGVKWGNMHWGHAVSKDLVHWKELGIALYPDKFGPMFSGGAVVDSNNTSGFGKPGQPPMVMYFTGARSWGQGLAWSTDGRNFSKMDRTVVHRINKDNRDPKVIWHAPTNKWVMVLYVERDNGQHSMQFLTSPDMKKWTKSSVTMGGTGDDRYLFECPEFFELPVEGQPSEKKWVLTGANSQYAIGTFDGSTFTPEAERLNGQLGRDFYASQTFSDQPEGRRIEIGWWRTHTDKGASSFNQAMSIPLELKLVRTAQGLRLTRTPVKELESLRNKTYLISARRLKAGSANPFSDIHEELLEIRTSIQPGNASQVTLDINGLPVVYDVAKQQLQIDGVTAPAPLVNGSLSLIIYADRIGVEVFTADGLLFMPVNVNIDAAKRALSLSVSGGTAKLGKTAVYGLKSIW
>NZ_CP043006.1|WP_148387788.1|4393785_4394631_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit-beta
MSWFKRIKQGIQTTTSEKKEAPDGLWHKCPNCKKTTTMKDLKANLYVCDKCNFHNRINSPEYFEIIFDNNEFEELFTNIYPKDELGFNDLKPYGARLKEAQKKSGLTDAMRVGAGDVNGKGLVVACMDFNFIGGSMGSVVGEKIARSIDHCIANKVGLMIISKSGGARMMESAFSLMQMAKTSAKLTQLAAARLPYISLMTDPTTGGVTASYAMLGDINTAEPGALIGFAGPRVIKETIKKDLPEGFQSAEFLLEHGFLDFIVDRKDLKNRISTLLELFEK
>NZ_CP043006.1|WP_148387790.1|4394662_4395103_+|SsrA-binding-protein-SmpB
MAELKNRSAYFEFAIEDKYIAGMVLTGTEIKSVRGGRVSFNDSFCYFSKGELFVKSLHIAEYSHGTYANHDPLRERKLLLQRKELKKMEKKIQERGYTIVPLRIFVTEKGLAKMEIGIGKGKKLHDKRDSIKQREVDRELRRNYKI
>NZ_CP043006.1|WP_148387792.1|4395260_4396379_+|hypothetical-protein
MLRYLPILFAIVLFSCKSGEKLYNQGKFDAAVESFVKKLQRRPQDATSLSLLPKAYEAAMDYHEGRARQALASNNDLKWESVRREYRSMQSLYDIIRSSPAANAVVKPKDYSAAISGAQENAAEARYARGIQLLDEGSRQGAREAYSEFDAALRLAPNYKDARQLRDQAYQMALINVVVSEIDVRSPYFQFSADQFRDALVRNLEQRRINNFVKFYDERYVRGDRDFRADQYMEMRFYDFIVGQTYVDRSQREVSKSIPVAGNKKDSIVYITVKATLFITRKTVASSGVLDYRITDVENNRTLRQDRVPGNFTWQNQFGTFRGDERALSDEDKRLIGGRDIPPPPPQELFLELTRPIYDRLATDLQSFYSRY
>NZ_CP043006.1|WP_148387794.1|4396424_4396850_+|META-domain-containing-protein
MKRCFPVFAALATFIFSACASSNKTAANNDADLFRTWQLIELDGQAIDTTKLNRPAQLTFEQAEQRVFGSAGCNSMTGKYTLEAPDKLSFSPMAATKMACPDMSVEMKFQEIIGKVNTWSVAEGFLILSQDDTPLAKFAAK

Crispr_ID: NZ_CP043006_10

• CRISPR_ID: NZ_CP043006_10
• CRISPR_location: 4561882-4561980
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_10

Consensus_repeat	Method
GGCGGAAACCGCTGCTGCCGGTATGCCTGACCG	CRISPRCasFinder

spacers of NZ_CP043006_10

>10.1|4561915|33|NZ_CP043006|CRISPRCasFinder
AGTTCCTGGCGGGAATATGAGGCCATCACTGCT

CRISPR arrays and Neighbor proteins around NZ_CP043006_10

CRISPR arrays

The CRISPR arrays of NZ_CP043006_10

>merge|NZ_CP043006|10|4561882-4561980|CRISPRCasFinder
GGCGGAAACCGCTGCTGCCGGTATGCCTGACCGAGTTCCTGGCGGGAATATGAGGCCATCACTGCTGGCGGAAGCCGCTGCTGCCGGTATGCCTGACCG

>NZ_CP043006|10|8|4561882-4561980|CRISPRCasFinder
GGCGGAAACCGCTGCTGCCGGTATGCCTGACCG	AGTTCCTGGCGGGAATATGAGGCCATCACTGCT
GGCGGAAGCCGCTGCTGCCGGTATGCCTGACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148388008.1|4562040_4562862_-|esterase-family-protein	unknown	unknown	gnl|CDD|223700
NZ_CP043006.1|WP_148388004.1|4561076_4561466_-|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|224523
NZ_CP043006.1|WP_148387994.1|4556654_4557545_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|380381
NZ_CP043006.1|WP_148388017.1|4565471_4566014_+|CAP-domain-containing-protein	unknown	unknown	gnl|CDD|349398
NZ_CP043006.1|WP_148388010.1|4563053_4563665_+|hypothetical-protein	unknown	unknown	gnl|CDD|176885
NZ_CP043006.1|WP_148387998.1|4558266_4559697_+|amino-acid-carrier-protein	unknown	unknown	gnl|CDD|376500
NZ_CP043006.1|WP_168208882.1|4558025_4558184_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148388015.1|4564194_4565124_+|paraslipin	unknown	unknown	gnl|CDD|223407
NZ_CP043006.1|WP_148388024.1|4569654_4570236_+|PhnA-protein	unknown	unknown	gnl|CDD|377140
NZ_CP043006.1|WP_148387990.1|4551634_4553278_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
NZ_CP043006.1|WP_148388000.1|4559739_4560384_-|NAD(P)H-binding-protein	unknown	unknown	gnl|CDD|225462
NZ_CP043006.1|WP_148388019.1|4566253_4568458_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148389989.1|4570440_4571001_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148388023.1|4569041_4569551_-|protease	unknown	unknown	unknown
NZ_CP043006.1|WP_148387996.1|4557587_4557968_+|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl|CDD|238308
NZ_CP043006.1|WP_168208881.1|4553297_4556372_-|TonB-dependent-receptor	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_168208883.1|4561574_4561844_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148388002.1|4560512_4560917_-|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224870
NZ_CP043006.1|WP_148388012.1|4563748_4564198_+|NfeD-family-protein	unknown	unknown	gnl|CDD|224501
NZ_CP043006.1|WP_148388021.1|4568572_4569004_+|DUF2147-domain-containing-protein	unknown	unknown	gnl|CDD|378304

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148388008.1|4562040_4562862_-|esterase-family-protein	gnl|CDD|223700	COG0627, COG0627, Predicted esterase [General function prediction only].	2.62195e-41
NZ_CP043006.1|WP_148388004.1|4561076_4561466_-|acyl-CoA-thioesterase	gnl|CDD|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	2.82587e-36
NZ_CP043006.1|WP_148387994.1|4556654_4557545_+|helix-turn-helix-domain-containing-protein	gnl|CDD|380381	cd06976, cupin_MtlR-like_N, AraC/XylS family transcriptional regulators similar to MtlR, N-terminal cupin domain. MtlR is a Pseudomonas fluorescens protein that acts as a transcriptional regulator of the mannitol utilization genes. It has an N-terminal cupin domain (represented by this alignment) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	1.413e-29
NZ_CP043006.1|WP_148388017.1|4565471_4566014_+|CAP-domain-containing-protein	gnl|CDD|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	1.65293e-28
NZ_CP043006.1|WP_148388010.1|4563053_4563665_+|hypothetical-protein	gnl|CDD|176885	cd08876, START_1, Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family. Functionally uncharacterized subgroup of the START domain family. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some mammalian members of the START family (STARDs), it is known which lipids bind in this pocket; these include cholesterol (STARD1, -3, -4, and -5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2, -7, and -10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). Mammalian STARDs participate in the control of various cellular processes, including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease.	3.40651e-17
NZ_CP043006.1|WP_148388015.1|4564194_4565124_+|paraslipin	gnl|CDD|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	4.623e-58
NZ_CP043006.1|WP_148388024.1|4569654_4570236_+|PhnA-protein	gnl|CDD|377140	pfam03831, PhnA, PhnA domain.	2.50803e-29
NZ_CP043006.1|WP_168208881.1|4553297_4556372_-|TonB-dependent-receptor	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_148388000.1|4559739_4560384_-|NAD(P)H-binding-protein	gnl|CDD|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	3.69712e-69
NZ_CP043006.1|WP_148388021.1|4568572_4569004_+|DUF2147-domain-containing-protein	gnl|CDD|378304	pfam09917, DUF2147, Uncharacterized protein conserved in bacteria (DUF2147). This domain, found in various hypothetical prokaryotic proteins, has no known function.	1.76487e-46
NZ_CP043006.1|WP_148387998.1|4558266_4559697_+|amino-acid-carrier-protein	gnl|CDD|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
NZ_CP043006.1|WP_148387996.1|4557587_4557968_+|ribosome-associated-translation-inhibitor-RaiA	gnl|CDD|238308	cd00552, RaiA, RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD).	3.7361e-13
NZ_CP043006.1|WP_148387990.1|4551634_4553278_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	5.77594e-66
NZ_CP043006.1|WP_148388002.1|4560512_4560917_-|Rrf2-family-transcriptional-regulator	gnl|CDD|224870	COG1959, COG1959, Predicted transcriptional regulator [Transcription].	3.48881e-26
NZ_CP043006.1|WP_148388012.1|4563748_4564198_+|NfeD-family-protein	gnl|CDD|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	9.9327e-23

Protein sequences

>NZ_CP043006.1|WP_168208883.1|4561574_4561844_+|hypothetical-protein
MNSQVIITRGNMEYLVQMDIERQPNAIVYHVRPHRHLWEQLPQAFDIIKPDHSDQPMYNEQGLTGLGKEIVGQIWEQLRLAEAQSAEIA
>NZ_CP043006.1|WP_148388004.1|4561076_4561466_-|acyl-CoA-thioesterase
MNFYTRKWVKPGDLNAHGTLFGGSLLRWIDEEAAIYAIIQLGTNRCVTKYMSEINFINSARQGDIVELGIKAVHFGRTSLTLTCQVRNKITHKTILTIDKIVFVSVDEAGVPVPHNRTEITYTDERLRE
>NZ_CP043006.1|WP_148388002.1|4560512_4560917_-|Rrf2-family-transcriptional-regulator
MGNVRFATAIHILTLLAYLKEEILSSEYIAGSININPVLVRKELSNLRQHGLVQSREGKGGGAMLAKSPKDILLADIYNAVRQAPLLGRSNTPNPDCAVGQQINKHIEQLYDKAEQTLVDQLGKTTLADFVQKF
>NZ_CP043006.1|WP_148388000.1|4559739_4560384_-|NAD(P)H-binding-protein
MKVALIGAGFVGAAILKELSARGHEVKVIVRHPEKVTVQDDKVSVVKGDVFSDELPALLQGSDAVVSAYNAGWTNPNLYIDFLEGSKAIQSALKTSGVKRFIVIGGAGSLYIDGQQLVDSPQFPAEYKTGATAARDYLTILKEEKELDWTFFSPAIEMHQGTSGERKGSYRIELETPVFNAEGRSILSVEDVAVVIADELEQPKHIGRRFTAAY
>NZ_CP043006.1|WP_148387998.1|4558266_4559697_+|amino-acid-carrier-protein
MEKIITAINDIVWSNAFIILCLATGVYFSVITRFLQVRFFKDMIRLLFRGKASDKGVSSFQAFAIAISGRVGTGNIAGVATAIAMGGPGAVFWMWLIAFLGAASAFIEATLGQIYKQVKDGQYRGGPAYYIEKGLGVKWYAAVFAVATILSTALFLPGVQSNSIAQSAFNAFNIPVAVTGGAVTLLLALIIFGGVKRIGKVAELVVPFMAAGYILMAVIIIAINISDVPAVFSLIFRSAFNLEATFSGVFGSAIAWGVKRGIYSNEAGQGTAPHAAAAAEVKHPVEQGLVQSFSVYVDTLFVCTATALMILFTGQYNVVNPEGGFIIEHLPGVKAGPAFTQAAVGVHFPTVGASFVALSLLFFAFTTIMAYYYIAETNLTYLSKKGNNRLMVWGLRALILLATFYGSIKTAELAWTMGDIGVGVMAWLNIIAILLLQRPALKALRDYQAQKKAGKQPVFRPKELGIRNADEWENMN
>NZ_CP043006.1|WP_168208882.1|4558025_4558184_-|hypothetical-protein
MQNSLPQAGKSMTGPRLTGGTGRRGRVELRAGKLMPRFEEEMTVAGIKMMKG
>NZ_CP043006.1|WP_148387996.1|4557587_4557968_+|ribosome-associated-translation-inhibitor-RaiA
MDIIIQSLGFKAGEALENFIREKLDTVKSDRIIRANVGLYLGADSNPENNYCEIRLEVPGNDLFVKKNSPHFETAVTECVEVLKQQVNKEKEKYTDSRQADAEKIQDALMEGSTQDEDTDLEDVVK
>NZ_CP043006.1|WP_148387994.1|4556654_4557545_+|helix-turn-helix-domain-containing-protein
MKPHFKPIPSASNLFKVELQESNKEFDYPWHYHPELEITYILSNQGVRYVGNSTENFYSDDLVLLGANLPHTWHSTAEAGQSSTAIVIYLKEGFLEKTWMQSIEFTAICNLFAAMNKGIVVDTAKARQLKPKFLQLLEAPPFDKMVLLLQILQELASNTAYRFLCEQEFNCALNHTDKARINTVYDYIQDHYQQQISLADIASKVNMSEEYFSRFFSRTMKKPFFEFLNEYKINRACKLLLETDMQISEVCYASGFESVSFFYRQFKKFKKCQPRTFRQNYQKVAELPSEKYAYAQ
>NZ_CP043006.1|WP_168208881.1|4553297_4556372_-|TonB-dependent-receptor
MGPVKKGVLALLAQVFFIVGAMAQDKVAISGLVTDGKIALPNVTVLIKGTNQGTTTNEAGEFTIQAERGQELIFSYIGFEKQSRVIGDQRRYEIIMEPSAGSTLNDVVVVGYGTARKASVTAAISTLKGKEVASTPIANLSNGLGGRVPGVIVKQGSGEPGRDGANIYIRGISSTGNSQPLMIVDGIPRAFQQLDPNSIESFTVLKDAAAVAPYGVAGANGVILVTTKRGSTGAPTLTYNGYVGFQNPVVLPEFVNSYQYATLRNAAAVNEGLDEPYSAEELQKFQDGSDPDAYPTFKDIWGSITNRNAILTNHNIEISGGAEKVKYYAALGYQLQEGMWATTNTRRFNLTLNLDANVTNTTKVSFNLNGRHQKDLYPATSTGRIFELIGYLHPLYGPLKFSNGMYGTFLTGSLFSSGYQKYNTTAIFTQVSVEQQLPFLPGLKARGTIAYDPSHSMNKIWSLPIQRASLDKSQTPYVIVDGIWGATKPSLRQDYTLEYQLTYQAGLDYARSFGKHHVTALALFEAKSNDYSTLGAERRNYNLTIDEINQGSSSQADMSTRGISSQGRQVGLVYRVAYDYAHKYMLEASGRYDGSYYFPPDERYGFFPAFSVGWRLSEENFLKGRLAWLDNLKVRASYGEVGALAGSPFQYMSTYNVLGTNYVLGNAAVQGIRERAEPNPYITWERAKKTDIGLEVGLWGGLLNIEADYFYEKRSNMLVNPDVIVPAEYGIGLSQVNAGIMDNRGFDFMISSAYRFSEDLEVSLGANMTYAKNKLLQVFETPTTYNNPNRRITGRPLGTQFGFKALGYFQESDFDGTGNLKSGIATQPWGAVQPGDIRYEDLNGDGRINDDDLTAIGDPAAAPRIMYGFSPAVRYKGFSLDLLFQGTARSNWYYHGSSIMPFWETMLPYVHNFDYWTPENTDAANPRLTSAPTVNNSQTSSFWMGNASYLRLKSATLAYNIPSAIMKKIRLQQARIFLSGQNIFTITDMIYYDPEIGPNNSWIPNNSWGYPNQKAFSVGANITF
>NZ_CP043006.1|WP_148387990.1|4551634_4553278_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MNMQFLRISLRAFIIFFSLLTLSSCSKFLDVAPKDQVSDATLWSTTGNADLFLNDVYASVPTLETGDPWENFSDNSMNGQAGRVSTNIYGPSIYTPSNAPNRWGQYVNIRKANLFIEKVTASALPDDWKALRLAEARFLRAYFYSILWMYHGGVPIITDVLNQNEQGDEVFRPRNTSQETFDFITAECAAIEPALPLTAESGRVTRGAVLALKGWCELFNAGALHNPANDPARWDLAATTFKKIIDLEHYDLFPDYNTLFFEENNNNIEVIFARQHLGGTSLANFRDGHIGPRFVRGGLTGWGHVDPTQDLVDEYFMANGLPITDPASGYDPQNPYVNREKRFYQSIVYDGSEWLGDIMIMKQGVGSPNATDLNNSSISTRTGYYIRKGINPKYASAQNNGNSANWIIFRYAEILLGYAEAKNESSGPDETVYSAINDIRQRSDLGPLPDGLTKDEMRIAIHQERRVELAFEEKRLPDLLRLRLAEVKLNGPLHAIKIDLVGGNPVYTVVPAGGGMRVFYPEKNYFLPIPQSARDKNSKLEQNPHYD
>NZ_CP043006.1|WP_148388008.1|4562040_4562862_-|esterase-family-protein
MLKSTRLLALLLILAAGTASAAGVDTVTTWSAAMKKNIRAVIVKPEQYDSRDNWPVVYLLHGYGGNYANWITKAPDIAKAADTYGMMIVCPDGGIGSWYWDSPADPAFRYETYVSEELVKWVDARYKTLKDKRGRGITGLSMGGHGALYLAFRHQDVFGVAGSMSGGVDIRPFPLKWDMAKRLGKYADEPERWEKYTVINMLHLLVPGALSIIIDCGTEDFFYEVNENLHQQLLLRNIPHEYYTRPGAHNWDYWPNAVEYQLLFMHHFFSRKG
>NZ_CP043006.1|WP_148388010.1|4563053_4563665_+|hypothetical-protein
MKFPIMLIMLTIVLFRFVFAAKPDNNAFKLVKHEDNIFLYERWINTGKGEKVREIKAVFLVRAAKENIIRVLKDETRGKTWNVNARDYQVMLTADENRWVSYIRYDIPWPFDDQDCCLAFQLSGNEVFFESISHRAFPENGNMTRITGTRGKWVLEDMHSGNVKITYLVTTDRSKKIPRWVSDPIVHSNLVKTMVKFRHFAEQ
>NZ_CP043006.1|WP_148388012.1|4563748_4564198_+|NfeD-family-protein
MDNLLHPAAVWFLIGFLLLLLEFALPGLILFFFGVGAWIVAILVLLFDLPINAQLIIFLVSSSLSVLFFRKWVKNLLWSRKKSSELIDDEFIGKTAMAETAITPGHNGKVNFKGSSWSARSEDMIAAGETVMITGNESILLIVKSTKAI
>NZ_CP043006.1|WP_148388015.1|4564194_4565124_+|paraslipin
MSTTTIILIILVLFLLVAFMSTFKVVPQRSVFIVERLGKYSRSLEAGFHILIPFIDRIAYKQNLKEQAIDVASQICITKDNIAVEVDGILYLQVIDPQKASYGIDNYRFAVIQISQTTMRSIIGKMELDKTFEERETVNGAIVEAVDKASDSWGIKVSRYEVKNISPPQSIKDAMEKQMRAEREKRALIAESEGDKQAKINRAEGDKQEMIARSEGEKQRKINEASGTASEIELIARATAIGIREIAHSINEEGGMNAVNLRIAEQYLTEFGKLAKVNNSMIVPADLSDIAGVISSITSVLNKTKVDLP
>NZ_CP043006.1|WP_148388017.1|4565471_4566014_+|CAP-domain-containing-protein
MKNPYLKSLAPALLLLIASCSKEPLTEFEPAKAPVTIALKDSVFTFDNPVDKALLLELINDVRSKGCNCGDTFMAPAPAVTWNEKLEKAAWLHNKEMSDSSYVSHTGKNGSSAGDRIRKMGYNYKAYRENIAFGILTERTIIKGWMGSVTHCMAMMDPDMKETGIAKYQNFWTQELALHY
>NZ_CP043006.1|WP_148388019.1|4566253_4568458_+|hypothetical-protein
MEKLKIPNQPARQLTELQYGRQTFLLSKVFPQLAKAASITHWEEITCVGYDPEKGKLEAIVSIKQASGYSGGLCTTGSKEYVRFFVDFKDGSGFQDMGYSSFKVADISEAPPGPQHPLKYMTHLFIDDEKYRKILTCKTAVIPTVRAVLSWNIIPSIDPDAIPHYGNVREANIQLKRRRRFIWGDIFDALQVKEKPDFLAHINLKEEVNIPIPPIPPLAVLYKEYQKAKVPDHRTFFTTIAPMISNGKKFSAVSSYNLFEVQKLKIDVKAITDLILKPVGQADVSFEELMCVGLNTPLDTLGAVIKIKKSSGFSGDLCTNGSKEHVAFWADWDNNGTFDTYLGTSSVTVHDISNMPADGLYYNVDLPVNLARRVRTCAQPNIIRIRAVLSWQSLPSTTDPNDLNTWGNRIDAVVQIRPSQGAHVEAELTHVGGVDRDLIDPVTFLVNSDTTNPTSHNNRPYGGWVRFNGIINRNGFNGVIKYKIEYKKYGAADSTYAAVSTSETFEMIDFTPDPNLEFSDPQSPADGWFIYKENPAIGLYNQTHYLAGWSTDGLTDGIYTIRFTHTDAFGVEQVADLFSLIVNNTHMSISTTANTSVDLTKSLDLVIDGGDCHCYDKTAANHIVSGHLRAVHPYFALWTLNLQPASHTHGTVPTPRHRYYDALPDAGDVGNLADNSDDGDENTPWSVDVSGMDNCGYTVSLTARSRVIRNSSTTFPWYGEKAVGFSVTDKCPNA
>NZ_CP043006.1|WP_148388021.1|4568572_4569004_+|DUF2147-domain-containing-protein
MKNTCWLILLFLLPTALFAQQADAITGTWLNEEKDAKVQVYRNGNNYYGKLVWIKDAYEDDGKTLRKDSKNPDAALRNRNLINLVILRNFVFDDGEWTDGKIYDPKSGKTYSSKMKLQGNTLEIRGYVGISMFGRTTVWTKAN
>NZ_CP043006.1|WP_148388023.1|4569041_4569551_-|protease
MRNLIIVMASGLLALSACTNTHKNTSADTSANTPDIPAATETLQTVMSVPPSVKAGEPVMLTFTVYNRSAKALEFCKWHTPFEGFIAAFLDVRNSNGEEVLYRGAMAKRVMPPPAEAYIQVPAGDSATVDIDLLKGYDLSAPGKYHAVYQAGGMSGLEQVNELDITVVP
>NZ_CP043006.1|WP_148388024.1|4569654_4570236_+|PhnA-protein
MKLDELLQQRSAGSCELCQSGDALTAYEVQPQSYSNEDNTILICDKCRMQIERKAELDSTHWKGLSDTMWSEVPGIKVVSWRMLHRLKHESWAMDNLDMMYLDDDTLAWAKATGDHDNDAAVELHRDCNGNVLQNGDTVVLTKSLDVKGSTLNAKMGTVVKHIRLVEDNTEQIEGKIEGQVIVILTKYVRKQG
>NZ_CP043006.1|WP_148389989.1|4570440_4571001_-|hypothetical-protein
MLSAVALFSGSAYAQKIKVTGGSLAALKNVREINTEFTYEKMSVGKFDKEEDYVKKRTEELNKKESGRGDTWAKAWVADRENRFEPKFNELLAKTGEVTVNEKAKYTIIFNTSFVEPGFNVGVMKKNAYIDGELLIVETENRNKVVARLTVEKAPGRSFWGNDYDTGERISEAYAVTGKVLAKKIW

Crispr_ID: NZ_CP043006_11

• CRISPR_ID: NZ_CP043006_11
• CRISPR_location: 4992506-4992617
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NZ_CP043006_11

Consensus_repeat	Method
ATGACAGATGAAATAATATTCCATCTG	CRISPRCasFinder

spacers of NZ_CP043006_11

>11.1|4992533|58|NZ_CP043006|CRISPRCasFinder
CCCCCTGAAAATTAGATGACAGATGAAATAACATTCCATCTGGCCCGTAAAAAGTTAG

CRISPR arrays and Neighbor proteins around NZ_CP043006_11

CRISPR arrays

The CRISPR arrays of NZ_CP043006_11

>merge|NZ_CP043006|11|4992506-4992617|CRISPRCasFinder
ATGACAGATGAAATAATATTCCATCTGCCCCCTGAAAATTAGATGACAGATGAAATAACATTCCATCTGGCCCGTAAAAAGTTAGATGACAGATGAAATAACATTCCATCTG

>NZ_CP043006|11|9|4992506-4992617|CRISPRCasFinder
ATGACAGATGAAATAATATTCCATCTG	CCCCCTGAAAATTAGATGACAGATGAAATAACATTCCATCTGGCCCGTAAAAAGTTAG
ATGACAGATGAAATAACATTCCATCTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148388620.1|4985354_4986440_-|DUF4974-domain-containing-protein	unknown	unknown	gnl|CDD|377406
NZ_CP043006.1|WP_148388613.1|4978474_4979293_-|DUF255-domain-containing-protein	unknown	unknown	gnl|CDD|239245
NZ_CP043006.1|WP_148388631.1|4993705_4994449_-|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|274576
NZ_CP043006.1|WP_148388617.1|4980720_4983837_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148390015.1|4997981_4998365_-|DoxX-family-protein	unknown	unknown	gnl|CDD|379266
NZ_CP043006.1|WP_148388627.1|4990910_4992497_+|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl|CDD|239202
NZ_CP043006.1|WP_148388625.1|4988939_4990856_+|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|237427
NZ_CP043006.1|WP_148388643.1|4999959_5000289_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148388639.1|4999013_4999481_-|ATPase	unknown	unknown	gnl|CDD|176868
NZ_CP043006.1|WP_148388641.1|4999487_4999811_-|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
NZ_CP043006.1|WP_148388622.1|4986517_4987090_-|RNA-polymerase-sigma-70-factor	unknown	unknown	gnl|CDD|274376
NZ_CP043006.1|WP_148388645.1|5000266_5000833_-|5'(3')-deoxyribonucleotidase	unknown	unknown	gnl|CDD|226895
NZ_CP043006.1|WP_148388615.1|4979305_4980724_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|185760
NZ_CP043006.1|WP_148388633.1|4995898_4996711_+|DUF1080-domain-containing-protein	unknown	unknown	gnl|CDD|368908
NZ_CP043006.1|WP_148390014.1|4987616_4988849_+|geranylgeranyl-reductase-family-protein	unknown	unknown	gnl|CDD|273936
NZ_CP043006.1|WP_148388619.1|4983848_4985225_-|hypothetical-protein	unknown	unknown	gnl|CDD|276965
NZ_CP043006.1|WP_148388635.1|4996831_4997908_-|erythromycin-esterase-family-protein	unknown	unknown	gnl|CDD|350610
NZ_CP043006.1|WP_148388629.1|4992639_4993671_+|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377630
NZ_CP043006.1|WP_148390013.1|4977250_4978432_-|DUF255-domain-containing-protein	unknown	unknown	gnl|CDD|234717
NZ_CP043006.1|WP_148388637.1|4998410_4999007_-|hypothetical-protein	unknown	unknown	gnl|CDD|226851

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP043006.1|WP_148388641.1|4999487_4999811_-|metalloregulator-ArsR/SmtB-family-transcription-factor	csa3	COG0640_csa3_CAS-I-A	1.5e-15	52.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148388620.1|4985354_4986440_-|DUF4974-domain-containing-protein	gnl|CDD|377406	pfam04773, FecR, FecR protein. FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm.	2.52742e-12
NZ_CP043006.1|WP_148388613.1|4978474_4979293_-|DUF255-domain-containing-protein	gnl|CDD|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.58028e-11
NZ_CP043006.1|WP_148388631.1|4993705_4994449_-|FtsX-like-permease-family-protein	gnl|CDD|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	7.37163e-24
NZ_CP043006.1|WP_148388617.1|4980720_4983837_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_148390015.1|4997981_4998365_-|DoxX-family-protein	gnl|CDD|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	7.44526e-16
NZ_CP043006.1|WP_148388627.1|4990910_4992497_+|FMN-binding-glutamate-synthase-family-protein	gnl|CDD|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	4.43859e-173
NZ_CP043006.1|WP_148388625.1|4988939_4990856_+|PAS-domain-S-box-protein	gnl|CDD|237427	PRK13559, PRK13559, hypothetical protein; Provisional.	2.45379e-24
NZ_CP043006.1|WP_148388639.1|4999013_4999481_-|ATPase	gnl|CDD|176868	cd07826, SRPBCC_CalC_Aha1-like_9, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	6.03891e-24
NZ_CP043006.1|WP_148388641.1|4999487_4999811_-|metalloregulator-ArsR/SmtB-family-transcription-factor	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	4.164e-18
NZ_CP043006.1|WP_148388622.1|4986517_4987090_-|RNA-polymerase-sigma-70-factor	gnl|CDD|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	1.21496e-49
NZ_CP043006.1|WP_148388645.1|5000266_5000833_-|5'(3')-deoxyribonucleotidase	gnl|CDD|226895	COG4502, COG4502, 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism].	8.98097e-46
NZ_CP043006.1|WP_148388615.1|4979305_4980724_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	6.72559e-42
NZ_CP043006.1|WP_148388633.1|4995898_4996711_+|DUF1080-domain-containing-protein	gnl|CDD|368908	pfam06439, DUF1080, Domain of Unknown Function (DUF1080). This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	3.98337e-39
NZ_CP043006.1|WP_148390014.1|4987616_4988849_+|geranylgeranyl-reductase-family-protein	gnl|CDD|273936	TIGR02032, Uncharacterized_protein_MJ1520, geranylgeranyl reductase family. This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll].	7.56775e-48
NZ_CP043006.1|WP_148388619.1|4983848_4985225_-|hypothetical-protein	gnl|CDD|276965	sd00038, Kelch, Kelch repeat. Kelch repeats are 44 to 56 amino acids in length and form a four-stranded beta-sheet corresponding to a single blade of five to seven bladed beta propellers. The Kelch superfamily is a large evolutionary conserved protein family whose members are present throughout the cell and extracellularly, and have diverse activities. Kelch repeats are often in combination with other domains, like BTB and BACK or F-box domains.	1.84452e-13
NZ_CP043006.1|WP_148388635.1|4996831_4997908_-|erythromycin-esterase-family-protein	gnl|CDD|350610	cd14728, Ere-like, Erythromycin esterase and succinoglycan biosynthesis related proteins. This group contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides act by inhibiting bacterial protein synthesis by binding at the exit tunnel of ribosomal subunit 50s, blocking the translation of the polypeptide. Erythromycin esterase, typically found in integrons and transposons, confers antibiotic resistance through the disruption of the drug ring structure. EreB substrate profile is substantially broader than that for EreA, being able to also metabolize semisynthetic derivatives such as azalide azithromycin.	6.53699e-06
NZ_CP043006.1|WP_148388629.1|4992639_4993671_+|winged-helix-DNA-binding-domain-containing-protein	gnl|CDD|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	5.49835e-64
NZ_CP043006.1|WP_148390013.1|4977250_4978432_-|DUF255-domain-containing-protein	gnl|CDD|234717	PRK00293, dipZ, thiol:disulfide interchange protein precursor; Provisional.	7.63613e-12
NZ_CP043006.1|WP_148388637.1|4998410_4999007_-|hypothetical-protein	gnl|CDD|226851	COG4430, COG4430, Uncharacterized protein conserved in bacteria [Function unknown].	1.205e-86

Protein sequences

>NZ_CP043006.1|WP_148388627.1|4990910_4992497_+|FMN-binding-glutamate-synthase-family-protein
MRKGFIISALTGIIGASLLGWYASPWWYVVLAMIAALFIMGINDMMQTKHSIMRTYPVFGRMRYWMEALRPKMYQYFVESDIDGRPINRIDRSTIYQRAKQEMDTMPFGTQLDVYEEGYEWMSHSISPKDFHKLDHNPRVMIGNKDCTQPYSASIFNVSAMSFGSLSSNAIEALNAGAKIGGFAHNTGEGGISPYHLRHNGDIIWQVGTGYFGCRDDDGNFSPAVFTKTASLPQVKMIELKLSQGAKPGHGGILPAKKNTPEIAAIRHVKPNTTVYSPPFHSAFNNPKELVQFLQQMRELSGGKPVGFKLCIGRKSEFIGICKAMMELDLYPDFITIDGGEGGTGAAPQEFSNHVGAPLLDGLAFVHNMLTGFNIRHHIRLIASGKILSGFHMLRAVALGADACNSARAMMMALGCIQALQCNSNKCPTGVATQDPALTIGLVVADKKQRIANYHEDTLRTFVELMGAAGIDDYKKLTRSHIYRRVFMNEVRTFEDIFPSLETGCLLINKIPEKYKQDYEMASADKWY
>NZ_CP043006.1|WP_148388625.1|4988939_4990856_+|PAS-domain-S-box-protein
MFKPITPLTTVIIYAICGILWILVTDTLLIQLPWQLSSLWLGQHFKGILYILLSSFLLYGLIRRNIARLELSQKAYMRMFRENPQPMWIFSKKTFRFLEVNDAAILLYGYSREEFLQMTILDIRPPEDIPKIRGNQQKQGNSPITSGNWQHYKKDGNLMYVRVEAFATTYEKEPAEVVTIFDITGQYLADDALKKQEQLLKTMINSTHNMVWAVSTRLELIAFNDTFRRHSGLFEGISEPSDYWRMYYEKCLAGEKQLFEYRMEDKDEDWQFAEISFEPILHKDRITGVACLAQNITERKRHEIALKKALERYDLISLATNDAIWDYDLASNKISWNEKMQQYYGFAGLEADVSYWQDRIHPEDREIMMRSVGEAVYKKQSRWQGEYRMLGVKGEYRHVISRGYILYNEKGEPYRLIGALQDVEDKVQQQEEIRKLSLIASMTHNPVIISDPEAHIEWVNKSFEDLTGYTLEEVRGKQPSSFLHGPGTNPRTLQEIQEKLSTSQPCVVEILNYTSDGEPYWVLMDITPVVDASGKIEHLIIIQTNITEKKKFVQQLEEKNKLLMEVAYISSHRLRKPVASMLGVIALMDKADLSNPENERLIAYIERLTNEMDTMLHEMADKCNRIYEVELRQNDPLF
>NZ_CP043006.1|WP_148390014.1|4987616_4988849_+|geranylgeranyl-reductase-family-protein
MKHTAVCIIGAGPAGAAAALQLHQYGIACTVVDKAVFPRDKVCGDGLSGKVITLLDRIDPAITGRLREMQAKTDSWGVTFVASNRASLNIPYRVKDDGLAPGLVCKRMDFDNFLVEEMKRCSHIELIQGQAVDQYTLQEDGYLIADSKSGFRIKAQLLIVANGAHSGFTKDVAGIHMEASHYCAGLRSYYKNVSGLDENGYIELHFLRSLLPGYFWIFPLPGGEANVGIGILSEIARKKKLNLKKLLLETIATDPVLKERFKDAELCGSIDGYGLPLGSKKRGLSGERYMLAGDAGHLIDPFTGEGIGNALYSGRYAAEQAQQAILANNFSAAQLKAYDEMIYHKLGPELKLSSRLQKLVRRPWLFNYLLKLGMGNKQLRELMACMFYELDLRKKLTRPAFYLKLLLNRN
>NZ_CP043006.1|WP_148388622.1|4986517_4987090_-|RNA-polymerase-sigma-70-factor
MNEQALVQQLISGDPAAFRTLYERYAPRLAAFTIKFQASSAETDEIVQETFIRTWVHRQRIDPSLPFEAYIITIAKNLIYNHLRKTGHRQNYLREVSLQSGLRQEDPAVQIRELQELIGKAMQQLPEKCRMVFRKSRLEGYTNAQIAEEMDISRSTVENQLNKALKIIRKNLESHGYGGALVTIALIIFK
>NZ_CP043006.1|WP_148388620.1|4985354_4986440_-|DUF4974-domain-containing-protein
MEKDLLKRYFENTASSEEIQKVNSWLADTSKRPEILAWIESYWKEERMETAPVPAFEEMFGKALAVEKQTGKVVAMKKNRRVWMYAAAASIAFFATGIWMGNYMKTRSSAAEHHKWVLSSAQTGKGQRTQLMLSDGSEVFLNAESELMFPSEMTLHPVVYLQGEAYFKLRDSSSSLVIKTRELVTTARGSQINISAFPTDSTVTVSVEKGKAEIAHNQETWPMLKIRPVKQKDSAAVITRIKEGEPHPLIQLRKPVVVKEKELMTFNKNSGLTDVSLHTDDEIYNWKDGKLSFYQAGEKEIMDKLNRWYGMKVIFTVPLEAHETYTGEFKDAKLEEVLTDISRSMHLECKIYSNVVYLIKK
>NZ_CP043006.1|WP_148388619.1|4983848_4985225_-|hypothetical-protein
MRFNNILINHYLPGTLMLGALLFSACKKEDKRSNLSGITEFSIPSTGVDFTVDQTTLKISNADSLPFESDVSALTASFTAVAGATVKIGSAVQQSGTTVNDYTNPVVYTVVAEDGVTTRQYTVQVNVAKLDPKTVSWQRSGEAGFGSFHDVQAGFFNGKFYAVNSTLGSFNAFTFGVFESADGVAWTRLKAADNNNDSIPMAEHGKLVTGFNNKMWMLGGLLPGTAMAFSAVTNKVWSSADGVTWTVSAPADPADRWSIRERINAVVFNNKMWVIGGSGYPAFGNTNSNGTAYNDVWNTTDGATWTKITDAADFLPRSNPAVFVYKDKIWLIGGIDNGRNYLNDVWNSADGLNWTQVTTASDFTARQGHRVVAHNGQLLLIGGETADGTQADLWVSEDDGVNWTKIEAGDVRALPGNFPARAHFSVFVNENVIWLMGGLMKNGNQHVIVSDIWKGGLN
>NZ_CP043006.1|WP_148388617.1|4980720_4983837_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRNTLLLALFLLGGSQALQAQSDTSMRKIDGTVKSAKDGVAVPFATIKVKGASRGTITDENGKFQILAKPTDTLVLSAVGFHKLESACKASLLTLALPVDQRTFSEVMIIGYGNERKRNITGSIASIDAKELAKSPALSFDNAIIGKAAGVNIISSSGVPGSATGITIRGLSSLNPDGNQPLIVIDGIPVYGSGRDVNNRNFNNSTAPVVGLGGTSVSDNYTPTQDFENNPLSALNPADIESIEILKDAYATAIYGSRASAGVILVTTKRGKKGSESFNVRMMTGTIQPIGKYKLLNGPQYNEVYNKYYRELGQSYTFSEQGNTDWVDEVTRTAISQQVDASMSAGGEKAQYYISGSYTSQPSYVINNDYKRYSGRVNLTYRPSPLFTAGVSMSMSFADNSSMNAMQIYRAALQKAPNLPVFNADGSYNYGRGTNPFGSMDVNPVADARLNTNTLKTSEGLGNIYLELKPLQWLTLRSEFGTQLSNGDAYTRRVKRPSGFGDDAVSSVNQNRKIVANNTISVLHTTGDHYINAVAGQSYEHSTESLTSLGGYGFFNDAIKSIAAANSKYVKASLTQQWALSSYFGRLNYEFRDKYLAGVTYRLDGSSRFSRNRRYVGFPSFSAGWRLSEEAFLSGRKWLDDLKLRGSIGFTGNNNSTSYYGSQGQYQLNSDNLSYAGTPILQTMQPDNPNLKWERTRSIDIGLDATVWDNRINITLDYYHRRIRDMVLSSAIPLYQGWVSQPQNIGDMMNAGLELTVKAEIIRRKDLVWSTNFNISRNTNKILRLNFSGDEVGLANDAFKYMKAGEPAAQFFLYDWRGVDPMSGNPQWSDNKGNISFTPPASLFSVVEDVNDFRRTYGSSLPDFYGGMGHTLSWRNWELDAFFSFSVGNKMINGSRATLLTYVTEDAYNLSTEILNYWLVPGHETDIPKLVNPSVTTSPGSSSIRDFTTSRTNSRFLEDASYLRLRTLRLSYNIIPRKLKVLRSLQLFATGTNLFTLTGYSGLDPEVNAFGSSAIRSGYDELTMPQTKTFQFGINVGL
>NZ_CP043006.1|WP_148388615.1|4979305_4980724_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MRKLFIISIVCFFGCNRQLDLAPENTLTDREVFRTEAGTEQALAEAYFSLLRAVTGNIAYVYGDFTTGNLHHSAYYEIYAIGESTPDDEVIASMWTAYFKAINLANNVIANIPEYAAYAVDIQDPLIAEARFIRAYAYLDLLKFFGDGALSGRMDGLGLPLQLTPFKGYNTGEVIPRSTNGQVFAQIIKDLEESIPFLKNNQPGDLRTRSRATKGGARALLARTYLYMGNREAAAAAARQVLEQVPAIYELTPSLTALFPANPGGTAQTLTKEYVLAFPVSHMVSSSTSTNNNLGNGYYFKRSFWINSTFIQSFEPDDKRVSELMYKGDQIYNPDHFNELTTFKFNNPNGRDNVPLIRLAEVMLTAAEGIAASEGVTQEAVTLLNNVRNRAVPGATPYTINDFASPEALIDTILQQRRWELAFEGQLRYDLIRTGSPLRSPDVPEDRKVLPVPQVEIDISNGLIQQNTGYKN
>NZ_CP043006.1|WP_148388613.1|4978474_4979293_-|DUF255-domain-containing-protein
MYAVRGMIKTIAAAMFTLCCSVTYAQQSVQFEDLSFEAAVAKAKTTGKLVFVDVRGMNVQQVMKDVETQVFTQDSVAGFFNSNCINIRVNMNSEEGKKFAPHLAMLMYPVYVFFDKDTTQIDYVSAGMVAKDHSLLMGKARKALSEAQMRATNTRAITFTKGSWKELLAKAKKENKLIFLDAYTTWCRPCIMMAKNVFTLNDVADYYNQHFINVSMDMEKGDGPAIAKKYKIKAYPDFLFVDGDGKLAHRSSGYQEAPEFIATGKEANQNKK
>NZ_CP043006.1|WP_148390013.1|4977250_4978432_-|DUF255-domain-containing-protein
MSFPAKSQISFKDSSWTWKAMLAEAKAQNKLIFMDAYAVWCGPCKWMTKNVFGVPEVGQLYNRNFVNAYIDMERGEGVALRKQYNVRYYPTYLFINGDGEVVHKVVGQTDTTSFIQHGLDAISPTRNLLYLSRHAGDNTTGYLKALKNAYDLTEAGKVALASLEAQPPSTWIEAANWELINDYVKDASSAPFLYVVENEKTFGERYGQDEVAQKLYSTFLAWPINYVSYPEQGKTLLDEKGFSDFMAKLEKSSYAKKDEIRAKSQLTIHYALRDWNKYAAVVNRMLSAKLIPMNIQGGDWLYGYAQNIQRFAAENKKAVKAATAWAKLLTTDIPGLNANQKVLYLDLYATLLEQKGDHDLAVDVRKNLDKEKLEAAKSGRPFQMLVKPAAPGK
>NZ_CP043006.1|WP_148388629.1|4992639_4993671_+|winged-helix-DNA-binding-domain-containing-protein
MKPRDILLHRLYHQQIAATRFTKPEEIVSWLIAMQSQEYAQAKWAIGLRIPGLKDADVENAFNQGRILRTHLMRPTWHFVSPGDIRWLLQLTAPRVQQINAYYYRQTELDAGIFRKAHTIISKTLEGGRFATRSVLQEALQKGKIKAEGVRLSGIMMHAELEGLICSGPRSGKQFTYALLEERVPPVKQLAAEEALAGFASRYFTSRGPATVQDFAYWSGLTVKDAQEGAMQLPANFIRENINGRDYIYLPIDPDKKLKNANFIMPDYDEYGMSYKDREALMPAENANSVFDHCFVLDGRIAGSWKKAPGNGITVTPFTVLSEARQKALEKAVQRYLAFQGGI
>NZ_CP043006.1|WP_148388631.1|4993705_4994449_-|FtsX-like-permease-family-protein
MHPSDTGREFLLNETALRKLDEPAAADAIGRPVRINGRQGTVVGVVRDFHHRSFHDAITPLCIVTGINWYGRCAIRINAARLKPALASIESTWNSIFPDHLYKYDFLDDRIARFYKADHMLLKLVQAFAVIAIIIGCLGLYGLVSFIAEQKNKEVGIRKVLGASLRSILWLFGREFAGLLLIAFVLAAPLAWRAMSNWLEGFAYRVEIGAGVFALSVLIMLLVALVSVGYKSVKAALMDPVGSLRAE
>NZ_CP043006.1|WP_148388633.1|4995898_4996711_+|DUF1080-domain-containing-protein
MIRKRFPFALPALLLAICCSGCAAAQEEPKWVPLFNGTDINDWIVKIHHHETGENFGNTFRVKDSIIQVRYDQYGDFNEQYGHLYYKQPFSHYHLKMEYRFVGEWCKTAPSYTILNSGVMYHSQDPRTMPREQDWPISVEMQFLAGLGDGQPRPTGNMCSPGTHIVYQGKLDPRHCINSSSKTYEGEQWVKAELIVLGDSLITHIINGDTVLQYSRPQIGGPVVNNYDPAIKTDGKLLSSGFIALQSEGQPIDFRRIEIMDLSPKAVTAP
>NZ_CP043006.1|WP_148388635.1|4996831_4997908_-|erythromycin-esterase-family-protein
MKIHLIACALCLLSSRLSAQSRCAATLVPGSNGMVYHAGHMEALPGFEQASAYFYGETHNADFEPAWKFHFIRHLHERYEVRDVFMEIGHAAAFLYNQYLLTGDTSLIKGLVYTEFYYREFWQDLYTYNLGLPEQERLIIHGIDFERPEAIRVLTMLRGQAVVPAVLEPVFTQMEQGELLPDFSRAFRELWAQIRMTFMEHDDAVKALYKGNYDIVQRIIRNDCPVTARAIPRNAAMFASLSAALKVNGIRRFAGFFGQAHTTYSSRSSLPNQLRKMPGFTGKVLTFGTVYKDAYAQGGRNKLISYTGMFRKSLLRVLYHRFMVEGCRAVVVPAADIGHKRMSATADHILFGRDVMVR
>NZ_CP043006.1|WP_148390015.1|4997981_4998365_-|DoxX-family-protein
MSKRNKIIYWIATLWLALGMVSTGIVQLLKVEEEAAVFTGLGYPLYLLTILGIWKLLGVVAVLVPKFPLLKEWAYAGFFIAMSGAIFSHIAVGNPVKDTLPPLLLLVLTVLSWYFRPADRRVAPVTP
>NZ_CP043006.1|WP_148388637.1|4998410_4999007_-|hypothetical-protein
MTMSSINPKVDFYFHKAGKWQEEYDKLRMLVLDCGLTEELKWGVPCYTSGKKNIVLIHGFKDYCALLFFKGALLNDAHGILIQQTENVQAARQIRFTNTREIVRMTPVLKAYIHEAIEVENAGLKVKLKEPAAFPVPEEFQHKLDALPALKAAFEALTPGRQRAYLLHFAAPKQSGTRESRIEKSMQHILNGKGLNDQ
>NZ_CP043006.1|WP_148388639.1|4999013_4999481_-|ATPase
MERKTKVNAEAGKQEIVITREFDLPLELLFKAYVEPEIVEQWMGTKVLKLENKKHGSWRFETSDAHGNVVFQANGVIHEFIPDRKITRTFEMENTAFAVQLEFLEFEKLTDDTSRLNMHIVFRSVEYRDQLLQMPFAQGLNMAHNRLQDIAGQLK
>NZ_CP043006.1|WP_148388641.1|4999487_4999811_-|metalloregulator-ArsR/SmtB-family-transcription-factor
MNLRRDVFQAIADPTRRAILLLVASQAMTAGAIAANFNTARPTVSKHLQILTECELLEQEQNGREIYYHLNPQKMREIADFIEPFRQLWDDRFNKLEAIMKKYKPKK
>NZ_CP043006.1|WP_148388643.1|4999959_5000289_+|hypothetical-protein
MQRDFFTYLLLPGFFYVSYFVLIPRLYFPKKIPGASNALGQSIPFDNYQFEILVSDIRNPNIHAAAIIYTTRHSHCWTLSAPAAERYGDVHGGDTARAYPSCTMKRPDA
>NZ_CP043006.1|WP_148388645.1|5000266_5000833_-|5'(3')-deoxyribonucleotidase
MARIVIDMDGVMADLTQHYINWYAERTGERISPEALIGVPETQGFPQEGIVPQFLHTPGFFRTAPVMPGSQEVIRKLMEQHEVFIVSAAVEFPQSLSEKIEWLNEHFPFISWKHMVFCGLKTIVEADYMIDDYDKNLRFFKGKPLLFSAPHNVGHELYKDYKRMDTWHDVADYFAAIEEPVVMHQAAS

Crispr_ID: NZ_CP043006_12

• CRISPR_ID: NZ_CP043006_12
• CRISPR_location: 5182419-5182556
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP043006_12

Consensus_repeat	Method
GGTGGGTCAACATCCCAGAATGA	PILER-CR

spacers of NZ_CP043006_12

>12.1|5182442|33|NZ_CP043006|PILER-CR
CAACCTTCCTTCACTCTAAACAAATAGAACCAG
>12.2|5182498|36|NZ_CP043006|PILER-CR
GGAGTATCCAGACGGAGAAGATTCCCAAAAAATGGT

CRISPR arrays and Neighbor proteins around NZ_CP043006_12

CRISPR arrays

The CRISPR arrays of NZ_CP043006_12

>merge|NZ_CP043006|12|5182419-5182556|PILER-CR
GGTGGGTCAACATCCCAGAATGACAACCTTCCTTCACTCTAAACAAATAGAACCAGGATGGGTCAACATCCCAGAAGCGGGAGTATCCAGACGGAGAAGATTCCCAAAAAATGGTGGCGGGTCAACATTCCAGAATGA

>NZ_CP043006|12|2|5182419-5182556|PILER-CR
GGTGGGTCAACATCCCAGAATGA	CAACCTTCCTTCACTCTAAACAAATAGAACCAG
GATGGGTCAACATCCCAGAAGCG	GGAGTATCCAGACGGAGAAGATTCCCAAAAAATGGT
GGCGGGTCAACATTCCAGAATGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148390022.1|5179602_5180064_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148388867.1|5171856_5172579_-|DUF4197-family-protein	unknown	unknown	gnl|CDD|379394
NZ_CP043006.1|WP_148388881.1|5180199_5180514_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_168208918.1|5185875_5189364_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148388870.1|5173579_5173918_+|hypothetical-protein	unknown	unknown	gnl|CDD|371572
NZ_CP043006.1|WP_148388904.1|5194720_5195050_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148388875.1|5174863_5176273_-|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148388898.1|5193219_5194230_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378964
NZ_CP043006.1|WP_148390024.1|5196833_5197091_-|Txe/YoeB-family-addiction-module-toxin	unknown	unknown	gnl|CDD|284238
NZ_CP043006.1|WP_148388873.1|5173937_5174849_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|197666
NZ_CP043006.1|WP_148388883.1|5180571_5181657_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_168208917.1|5184349_5185717_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|185760
NZ_CP043006.1|WP_148388877.1|5176633_5178340_+|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl|CDD|293749
NZ_CP043006.1|WP_148388896.1|5191914_5192802_+|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|275036
NZ_CP043006.1|WP_148388879.1|5178548_5179304_+|lipopolysaccharide-kinase	unknown	unknown	gnl|CDD|283861
NZ_CP043006.1|WP_148388893.1|5189532_5190111_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511
NZ_CP043006.1|WP_148390023.1|5195265_5196684_+|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl|CDD|293751
NZ_CP043006.1|WP_148388887.1|5182719_5184120_-|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|239264
NZ_CP043006.1|WP_148388868.1|5172726_5173569_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|180446
NZ_CP043006.1|WP_148388894.1|5190539_5191712_-|DUF4974-domain-containing-protein	unknown	unknown	gnl|CDD|226235

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148388867.1|5171856_5172579_-|DUF4197-family-protein	gnl|CDD|379394	pfam13852, DUF4197, Protein of unknown function (DUF4197). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 228 and 249 amino acids in length.	3.82453e-100
NZ_CP043006.1|WP_168208918.1|5185875_5189364_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	7.66146e-140
NZ_CP043006.1|WP_148390023.1|5195265_5196684_+|sulfatase-like-hydrolase/transferase	gnl|CDD|293751	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.	2.44016e-151
NZ_CP043006.1|WP_148388870.1|5173579_5173918_+|hypothetical-protein	gnl|CDD|371572	pfam11512, Atu4866, Agrobacterium tumefaciens protein Atu4866. Atu4866 is a protein with unknown function from Agrobacterium tumefaciens however the structure has been determined. Atu4866 adopts a streptavidin-like fold and has a beta-barrel/sandwich which is formed by eight antiparallel beta-strands. Atu4866 has a potential ligand-binding site where is has a stretch of conserved residues on the surface.	2.11666e-42
NZ_CP043006.1|WP_148388879.1|5178548_5179304_+|lipopolysaccharide-kinase	gnl|CDD|283861	pfam06293, Kdo, Lipopolysaccharide kinase (Kdo/WaaP) family. These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica.	0.00234631
NZ_CP043006.1|WP_148390024.1|5196833_5197091_-|Txe/YoeB-family-addiction-module-toxin	gnl|CDD|284238	pfam06769, YoeB_toxin, YoeB-like toxin of bacterial type II toxin-antitoxin system. YoeB_toxin is a family of bacterial toxins that forms one component of the type II toxin-antitoxin system in E. coli whose antitoxin is represented by YefM, found in pfam02604. The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair. When the plasmid is lost, the antitoxin is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth. These toxins are highly potent protein synthesis inhibitors, specifically blocking the initiation of translation. In the case of YoeB, it binds to the 50 S ribosomal subunit in 70 S ribosomes and interacts with the A site leading to mRNA cleavage at this site. As a result, the 3'-end portion of the mRNA is released from ribosomes, and translation initiation is effectively inhibited.	2.61592e-48
NZ_CP043006.1|WP_148388873.1|5173937_5174849_+|helix-turn-helix-domain-containing-protein	gnl|CDD|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	2.18324e-17
NZ_CP043006.1|WP_148388893.1|5189532_5190111_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	1.01486e-27
NZ_CP043006.1|WP_168208917.1|5184349_5185717_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	1.30994e-25
NZ_CP043006.1|WP_148388868.1|5172726_5173569_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|180446	PRK06180, PRK06180, short chain dehydrogenase; Provisional.	1.82718e-103
NZ_CP043006.1|WP_148388896.1|5191914_5192802_+|T9SS-type-A-sorting-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	5.94677e-07
NZ_CP043006.1|WP_148388898.1|5193219_5194230_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378964	pfam12833, HTH_18, Helix-turn-helix domain.	1.1202e-08
NZ_CP043006.1|WP_148388887.1|5182719_5184120_-|redoxin-domain-containing-protein	gnl|CDD|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.64355e-16
NZ_CP043006.1|WP_148388877.1|5176633_5178340_+|sulfatase-like-hydrolase/transferase	gnl|CDD|293749	cd16025, PAS_like, Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.	0
NZ_CP043006.1|WP_148388894.1|5190539_5191712_-|DUF4974-domain-containing-protein	gnl|CDD|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	3.3617e-21

Protein sequences

>NZ_CP043006.1|WP_148388883.1|5180571_5181657_+|hypothetical-protein
MMNGKHTLAVFSLLATAIFIILWLKNSTYLPNVKNNGFKRKWIENLVVLEKEKNISSAFARFPGTHSGYNFLATKDPFVLVKFSEDLNPKDTFTLNLPKINASYNPNILVVDSFNVLVALPNSALSFTISLDSEKIDSVRLQSDIFTRFSKMRNSSAIVRALTKDQTRQSFKKIDLKSGEVIKEASIVENDKSYMGFDSDGILQFDPIRNLFIYVQYYRNEVHCFDTSLNLIYKSNTIDTISTNSAVYTKLEKFDSQKVTSSAARLIVNRECIVDSKNGVYFILSNLRSDDATNSDFRENNTLDIYKIDDGMYLGSFTIPKRNSTYFLSATIDSSHLLVLNKGNLAKYRIDYSKLLQIMAK
>NZ_CP043006.1|WP_148388881.1|5180199_5180514_+|hypothetical-protein
MTKLKFSFGLLVAICAIALTVTTNAKSIFAACSTVVTITNPDPDVVFSQGDSYLSVNQYQGRTDSQLNTPSFDTEACDGVLEEFCCATKANPSAPVVLLYRTIP
>NZ_CP043006.1|WP_148390022.1|5179602_5180064_+|hypothetical-protein
MQRSVYRKRKILHATLEAIIGLFILLWIYTGLNKALDLENFKVQLGRSPFIQPLAPWIALVLPVGEILLALLLVIKRTRLIALYTSFFAMALFTGYVFIMLRYSYDLPCSCGGVLEALSWENHLIFNFTGTILAAVGIFLQIGTTASKSVKSE
>NZ_CP043006.1|WP_148388879.1|5178548_5179304_+|lipopolysaccharide-kinase
MSIHIDISPGYEFLRDYVEKIPQRFNSLGEVVHKTRNVIRVDMGNNVKLVIKSYRKIYLLNRFFYAHVLPSKAKRAYLYAKMLIDKGFTTPEPVAYIECIRNGLMQESFFISTYTDYTELKYIADMPPEEGGAVLKALALYTFKLHQQDIYHKDYSVGNILFKKNGDSYDFTLVDNNRMKFSRSSFAYRMKNLRRLDLPLPALAYLCQEYARLSGENELLALTTMLNYRRRRVLFAYRKGWMKGFLGGRSL
>NZ_CP043006.1|WP_148388877.1|5176633_5178340_+|sulfatase-like-hydrolase/transferase
MRIRRKPLAIVSLSAALAALAVFAGFRSAPPAAKAPRPNIIVILADDLGFSDVGCYGGEISTPNIDYLAQNGIRYTQFYNTSRCCPTRASLLTGLYNQQAGIGKMTELENQPGYQGHLAENTVTLAEVLKTAGYRTAMTGKWHVSNTFEQKTREAQMAWLNHQQEGGDFSPISQYPVSRGFDKFYGTLWGVIDFFDPFSLVNGVTPVKTLPPDYYHTDAINDTTAAYIREFAQSPDPFFIYVAHNAPHWPLHALPEDIAKYKDTYKGGWDSIREARYRKMVQLGLIDPAKTPLPKRWEDELSWENNPAKEWDAEAMAVHAAMVDRMDQGIGRIIQALRETGQLDNTLILFLSDNGASPEDCSAYGPGFDRPDETRDGRKIAYPTKKEVMPGPQTSFASIGRRWANVANTPYQYWKAESFEGGIHTPLIAHWPKGVKVKKGSFSAHTGHVMDFMRTFTELAGAEYPAHFEGRTITPSTGISLAPSFRDRKSSGHATLFNEHFGARYARSGNWKLVSAAGDSTWRLFDLATDKTELQDVAAAHPDKVRQLDSLWRQWAWSHQVFPKPGRR
>NZ_CP043006.1|WP_148388875.1|5174863_5176273_-|right-handed-parallel-beta-helix-repeat-containing-protein
MTKNRFNSSTMLGLFITLFLTFTSCTKTISEELPLETENPAKPAPDPDPNAKQYTLVPDKEGRLVIDDKAGTYKPGDIINLKGTFSAVIFTNLNGSAGRPITVRNAPGTTLRIGNPAWNSGSWATALSFRKSHHVKVEGTTQGNFVINGSTQPGRPAYFNLTLSERSDNFEISNITITNGGTGIWAKTDPVKADPLTHYPNAYMENLLIHDVSVTGTHNEAMYIGHTATYWNLTTNYSYYTLPAGAVLGQEYVQPIKWRNVKIYNNVIKNIGADGMQTAAIDQLEVYGNDITNWGMQHNPSHSGGLLIGGRVTNSNIHDNIVHDGWGELFQFFGSGENGATHIVRNNLFRDNFANDGVSFRGTDDAVVQFLNNTVARTSGVSLRINGYLGMKSSQIVNANAFIEPRTAGGSNIGDRAYIYTENEAKVTEGTGANANTKLASVSAAGVDVNNFYLPLSGSALINSGFRKK
>NZ_CP043006.1|WP_148388873.1|5173937_5174849_+|helix-turn-helix-domain-containing-protein
MAKTETLEDFYRQKLNWLPENLQKDIGHFNVFRLEDCMGTDKAPVKYSRREFYKVTLMRGRHAYHYADKSVEVSGTTLLFFNPNVPYTFEQLSGDSTGFFCIFKEAFFTSHLRNNIRELPMFSPQGRPGYQLSKQQDKLVSGIFEKMLTEIASDYVYKYDLIRNYVTEMIHHAMKMQPTETLYQHVDANARITAVFTELLERQFPIESPTQRFSLRSARDFAEQLAVHVNHLNRAIRHTTGKTTTDHIFERLASEAMALLKHTNWNISEISYSLGFEEPAHFNHFFRKQTSQTPTAYRANALA
>NZ_CP043006.1|WP_148388870.1|5173579_5173918_+|hypothetical-protein
MAALHYLIISCTLLLSCAKPRTAAISTSSTMNKYIGMWVTGDGYIRQELLPNGRYDEARGQKQSAYTGRYEINGDHIQYWDDTGFTADGTFRGNDTLHHGGYIFYREKPKQP
>NZ_CP043006.1|WP_148388868.1|5172726_5173569_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKTKVWFITGASKGLGLALVQKLLAAGYRVAATSRNVADLQKAVGAGPDNFLPLGMNLLDEADVEKGIQQTAAHFGQLDVIVNNAGYGLLGALEELSDAESRANFDVNVFGSLNVIRKALPILRAQQSGHIFNVSSIGGFTGAFPGFGIYCATKFAVQGLTESLATEVKPFGIHATIVSPGYFRTSFLTDNSLGVTKTEIPGYGHVREVQNAHQHSYNGNQAGDPDKAADVMIQVAEQPEPPVHLFLGADAYALAEEKISSVRKDMEQLKNLATATAYAV
>NZ_CP043006.1|WP_148388867.1|5171856_5172579_-|DUF4197-family-protein
MKKRILGALTVLWLFTGCETTQQILSTLPASTGQTGSTAQIAAGLKEALTIGTQNSTGRLSSLNGFFANAALKILMPPEAKKVESTLRNVGFGSLVDKAVLAMNRGAEEAAKSATPIFVNAIRQMTITDAIGILRGGDFAATNYFKQKTTDALTTAFRPVINNALKNVDATKYWSDIFSTYNKFSSTPVNTDLTAYVTEKAIAGIFHEVGLEEQKIRQDPAARVTDLLKTVFGSPLAQTR
>NZ_CP043006.1|WP_148388887.1|5182719_5184120_-|redoxin-domain-containing-protein
MENIRLCLTVMLMISFTLCIRGQQTTPLQQNEVARVFEPLRIGDRVPNGVKLENLRNYPARSVELADFKGKLVIIDFWNKWCIPCISAFPKMEKLQQRFGDSIQILLVTTDTDEELKSLFERSEIVKNTKLPIVTSDKILKKLFPHSSVPYHVWIDKEGFVRYTLAAYNTNLESIQKFLSTGEVSLTLKHDKFDHALKFGPLFNQIVGPNYNQMKQVQAYTLFTKMNLYNNGAMQVVDTASKRMLNFPILGLFQTAYGLVHPQSPIQSDGLLARVTNAMKVSIITKSPENKDKYYYPDQNSIDYGKWMSENIYCYETVFEPSIMKLPAERRAKVQDSLVIRDLDRFFSVKSSIEYKMEKCLVITSTGGSHLFRTKGGEPLQERTKENIIRIRNYSVSSMIAIINKYFMKFPGEIPVIDETGYSGTIDVDFRVGDRSIEELDKDLRMHGLTIKVEDRMIRCLTLKEV
>NZ_CP043006.1|WP_168208917.1|5184349_5185717_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKKYCFVIGFSLSIIFFISCSKEWLDEKPDKNLTVPETLDDFEAMLDNLDMNSRSALTLGELATDGHYVLESRWATGFPDFLSNAYTWSNERPYVNIADWNSPYYCISTSNVVLEGIGKIKSTGENSERMRRIRGGALFNRARHLYELAQVFCPPYNGLSSELDLGLPLRFESDINIRSVRSTLKATYQAIIDDLMEAKNLLPIRPIFKTRASQPAVFALLSKVYLSMGNYEESGDFADSCLVLYSTLLDFNKINTSANFIGTFNDEVIFHSIGSPYNMLTSSGKIEKTLYDSYLMDDLRKKAFFRIESAGTIVFKGNYYNSTTNLFLGLSTSDLYLIRAECFARKGDVEKAMRDLNLLLLNRYDSNTFVPIVAENSNDALHKVLSERKKEFVLRGQRWTDLRRLNTDPQFAETLTRTIGGNTYILEPNSFRYTFPIPDDVIQLSGIQQNIGWER
>NZ_CP043006.1|WP_168208918.1|5185875_5189364_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MSIFYCRSKRERWLLLLLVLLSLQSKAFTQDSSRITVQGNNIPIETALRQIEKQSGFSFVYGKPTLDDTERITVDISGKGFTAVMDALLGARGIVWKFRGGAVVLSRESIRRSELPYSTKDTIPKINVSGLVRDFSGKPLSGVTVAVKGAQVITVSDSSGRFELFKVNANATLLISSIGYSKKEIKIRGNSNLFIELEERITELKNIEVLSTGYQDLPKERVTGSFSHIDNELYNRQLGTNVLERILNVTSGLNFESRNQFVNNRSAITIRGISTINASMQPLVVVDNFPYEGDLNNINPNDVESVTVLKDAASASIWGVKAGNGVIVIKTKRGRYNQESKIQFVSNVSIAEKARIFTTPTMSVNELIDFQKSLFASGYYNDYDDSYPSFNYFPAIPEVAEVLLAHRRGEISQFQADEQIAYLRSNDIRNDITKYLLQTGINQQYAINLSGGGVKHKYYGSIGYDNNRSTSIGDNFKRLTVRLDNTYSPIKNLEANGYIVYVSSRTDNNSVSLSGLSALPYNRIIDDEGNYLSVTNEIRKKFVDTASYPSLYDWNYRPLDELRNRNNRGDRQEMRLGTGFRYSVIPGLSVEAKYQFQYEISHLRNLNSLNTYFTRDLVNRYMSIDNGRVIYGVPPGSILDMQDSNIKSWNFRSQLNYSKTLKSSSLVGLAGVEFREVKMEQEFIRKYGFNEQTSQTSIVDYVTQFPYLSSNGFSTANVAYLDNISGNISRYRSIFGNAAYTYDGRYTATVSGRIDGSNFFGVKANQRKVPLWSAGLSWNISEENFFTLKSFPYLNVRLTYGFNGNTNNSAAAYPLVSYSIASLTQAQSATLISPPNPSLRWEKVRMTNVGIDFGMIKDIISGSFEYYQKKGIDLISDIQVDPTSGFTKYTTNNAEIKGVGVDVSINSNNIRLNNFKWSSNFLFSFTKDKVLKYSITPTTVSQYLSEGTPIVGDPLFKIYSYEWAGLDPVTGGPRVYLNDTISSFSTAATNSKIEDLVLAGSTMPVFYGALRNNFSFRNFSLSVNITYKMGHYFRRSSVRYTNLYRGLNEHSDYSKRWLEPGDELETHVPSIPSSGDASRVNSIYSQSDILVEKADHIRLQDIRLSYDFGNGVRNYKVFKGAQIFAYATNLGLIWKTNKEGVDPENQNMAASRSLAIGLNVTF
>NZ_CP043006.1|WP_148388893.1|5189532_5190111_-|sigma-70-family-RNA-polymerase-sigma-factor
MKERDIISEIQQGNRHAFRHAFTNHYKELIRYAYTIMKDDKEAEDVVQECFAILLGKPALWEKIKDIRGYLMRMVHNQCMWKIRERQSQEKKYEKYAHWANTTTYGGLPEVLRDINQHENESLVQYLMSVLTPMRRQAIELVYIEQLSYAEASDRMGISKNSLKTHLKLAMVKLRSLIHILLVICMCIRIQI
>NZ_CP043006.1|WP_148388894.1|5190539_5191712_-|DUF4974-domain-containing-protein
MPDIIHIRELLIKAHFGELTPEESVELEALLAAHEEARQIRDEISMLPREEMAAMLDRLDPEEAWQKVLEKEEELRRHKTVRRRNLVIGSAVAASVMLAAIFLLPPIKQRSVDLAGISASGTGTPGEQATLQLANGKVIVLHDSGQQVLSLGNAQLSNTNRVLKMAALAGDADLEASGWNTITVPNRLDYRIELPDGSVVWLNSTTKFRFPLSFRGRKSREVYIEAGEAYFQVAQQAEAPFVVHTSEADVHVLGTEFNVNAYQAGQVVTSLVNGKVAVSAGGGKRKELKPNQEAVVKEKADNIMVQPFDLSTTVSWREGIHYFRNAPVSEIAVMLSRWFNTELVIDNPEIAKVQFRGRLDRNRPLSEFVELMNLTKDANFYWKDGVLHCK
>NZ_CP043006.1|WP_148388896.1|5191914_5192802_+|T9SS-type-A-sorting-domain-containing-protein
MKRLLLFAAFVLPNLPLFAQCSVDIGEDEFQPICYTYWGMYATQLAPWAIEEPGWTYSWSPITGLDDPNILQPMANPSVTTTYTLTVTAPGCGTFIAGTSRVEIMPNTPTITPAGPITHHYTDTSAVILTSDAPYGGWYKNGTLVQGCCNDTYIVNFNNSSSNTTDYYRYYSPYSCNWWSNTIEVNYIGCGLCRVTIINEITDPAKRQNEKIKAMRALESIRLFPNPASSRLSISAQTPVTEVEIRNVSGATVKKIKTNGTMPCSLNVEDLPTGYYICTMTMSGGIKQLPFVVRR
>NZ_CP043006.1|WP_148388898.1|5193219_5194230_+|helix-turn-helix-domain-containing-protein
MQPSLPSAILWIERPTFWHPAEPSAKIAKEYASLIMPCSVVDFSRTKLHEKLCQKVDLGDFNIWTHDVLAFLTHQLGPYTPEHILALHYMSQSNVDAAILNKIPVKLIASQYNLFNLPEGLNKATLSAGEHFFSFHINTQPGTFARLKDRFPELARLAEKEEQMKMAPGPVNNSPLMINDAIRLLIESILACRFINLQAKYYLYRACVDLHIIFANQDKNLELDRKALTLREENCLKKCYDILTRRLDIAITPAEMARTTGMNARDLSQAFLHEYGMPMEKFHYMLRMMEAYRSIVQGTGSLSGIAHRTGFINGRQLTREFVAHYHIHPHELTHAQ
>NZ_CP043006.1|WP_148388904.1|5194720_5195050_+|hypothetical-protein
MNSFLGLPPYESKPAFDDRNFKAYVKQRYFDQLLSHKKVSFRVAIILTIMASICLILAITIKTDYYTLSFGLATVPFSIATQRSFSHYYRICKDIATFVDKALEWDEEV
>NZ_CP043006.1|WP_148390023.1|5195265_5196684_+|sulfatase-like-hydrolase/transferase
MYAQTARPNIVIFIADDVSYNDLGCMGHPVLKTPAIDKLAKNGIRFSNAYLTTSSCSPSRVSILTGRYPHNTGAAELHSPIPPGQVAFPKLLKESGYYTAQAGKWHLGSSGIKPDGPFLDAFDRVGGSHADGGGPGGEQAWVEYLQQRPKDKPFFMWFAAQDAHRGWDNAPKPVQYSAQDVQVPDNLANTAATRTDLVRYYEEVSRFDHYVGKVVDELKAQGILENTLIIVMADNGRPFPRNKTRMYDEGIKTPLIIHWPAGVKGRNQVSSSLVSAIDIAPTILEVAGISECASVQGKSFKTLLAEPTAKFRNYVFAEHNFHSFRAYERMVRTDKYVYIENGLPEQSNVGATDIMGGAAGAELKKHYLAGKATPLQALIFITPQPQFEFYDHSADKDQLINLYGHKGYKAQQQHLADILETWKKETGDDQPEDLTPDWYDRWDNKALPEKGKRGTMPGSLQNATSIQKPGPF
>NZ_CP043006.1|WP_148390024.1|5196833_5197091_-|Txe/YoeB-family-addiction-module-toxin
MELVWQTNAWDDYLYWQEQDKKILQRINDLIKDTLRSPFKGIGKPEPLKGDLSGFWSRRITDEHRLVYAVKDKRLHIIQCRFHYH

Crispr_ID: NZ_CP043006_13

• CRISPR_ID: NZ_CP043006_13
• CRISPR_location: 5616363-5616457
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_13

Consensus_repeat	Method
GCGGCACCCGCAAACATCATGAGC	CRISPRCasFinder

spacers of NZ_CP043006_13

>13.1|5616387|47|NZ_CP043006|CRISPRCasFinder
TGTCACTGCAATGCCTGTTGTCAGTACGCTGTAGCAACTCTTTGAAG

CRISPR arrays and Neighbor proteins around NZ_CP043006_13

CRISPR arrays

The CRISPR arrays of NZ_CP043006_13

>merge|NZ_CP043006|13|5616363-5616457|CRISPRCasFinder
GCGGCACCCGCAAACATCATGAGCTGTCACTGCAATGCCTGTTGTCAGTACGCTGTAGCAACTCTTTGAAGGCGGCACCCGCAAACATCATGAGC

>NZ_CP043006|13|10|5616363-5616457|CRISPRCasFinder
GCGGCACCCGCAAACATCATGAGC	TGTCACTGCAATGCCTGTTGTCAGTACGCTGTAGCAACTCTTTGAAG
GCGGCACCCGCAAACATCATGAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148389364.1|5621043_5621445_+|DUF1573-domain-containing-protein	unknown	unknown	gnl|CDD|377880
NZ_CP043006.1|WP_148389368.1|5626035_5626851_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148389369.1|5626926_5627430_-|50S-ribosomal-protein-L17	unknown	unknown	gnl|CDD|235522
NZ_CP043006.1|WP_148389366.1|5623946_5625089_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl|CDD|237139
NZ_CP043006.1|WP_148389357.1|5609038_5610295_-|MFS-transporter	unknown	unknown	gnl|CDD|340874
NZ_CP043006.1|WP_148389353.1|5606087_5607026_+|malate-dehydrogenase	unknown	unknown	gnl|CDD|133424
NZ_CP043006.1|WP_148389371.1|5628610_5629216_-|30S-ribosomal-protein-S4	unknown	unknown	gnl|CDD|235411
NZ_CP043006.1|WP_148389370.1|5627539_5628535_-|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl|CDD|235359
NZ_CP043006.1|WP_148389358.1|5610370_5611072_-|DedA-family-protein	unknown	unknown	gnl|CDD|182775
NZ_CP043006.1|WP_148389360.1|5612804_5614256_+|amino-acid-permease	unknown	unknown	gnl|CDD|129987
NZ_CP043006.1|WP_148389359.1|5611154_5612534_-|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl|CDD|234968
NZ_CP043006.1|WP_148389356.1|5608583_5609045_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
NZ_CP043006.1|WP_148389365.1|5621549_5622743_+|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|181036
NZ_CP043006.1|WP_148389354.1|5607193_5607721_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148389363.1|5617332_5618259_-|DnaJ-domain-containing-protein	unknown	unknown	gnl|CDD|237667
NZ_CP043006.1|WP_148389355.1|5607925_5608507_+|polyisoprenoid-binding-protein	unknown	unknown	gnl|CDD|225228
NZ_CP043006.1|WP_148389352.1|5605467_5605968_+|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|376354
NZ_CP043006.1|WP_148389361.1|5614484_5615195_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl|CDD|237084
NZ_CP043006.1|WP_148389367.1|5625184_5625991_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148389362.1|5616524_5616776_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148389364.1|5621043_5621445_+|DUF1573-domain-containing-protein	gnl|CDD|377880	pfam07610, DUF1573, Protein of unknown function (DUF1573). These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.	3.44635e-33
NZ_CP043006.1|WP_148389371.1|5628610_5629216_-|30S-ribosomal-protein-S4	gnl|CDD|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	5.10795e-112
NZ_CP043006.1|WP_148389369.1|5626926_5627430_-|50S-ribosomal-protein-L17	gnl|CDD|235522	PRK05591, rplQ, 50S ribosomal protein L17; Validated.	2.35889e-56
NZ_CP043006.1|WP_148389366.1|5623946_5625089_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl|CDD|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NZ_CP043006.1|WP_148389357.1|5609038_5610295_-|MFS-transporter	gnl|CDD|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	9.45543e-26
NZ_CP043006.1|WP_148389353.1|5606087_5607026_+|malate-dehydrogenase	gnl|CDD|133424	cd01339, LDH-like_MDH, L-lactate dehydrogenase-like malate dehydrogenase proteins. Members of this subfamily have an LDH-like structure and an MDH enzymatic activity. Some members, like MJ0490 from Methanococcus jannaschii, exhibit both MDH and LDH activities. Tetrameric MDHs, including those from phototrophic bacteria, are more similar to LDHs than to other MDHs. LDH catalyzes the last step of glycolysis in which pyruvate is converted to L-lactate. MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. The LDH-like MDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	5.45405e-174
NZ_CP043006.1|WP_148389358.1|5610370_5611072_-|DedA-family-protein	gnl|CDD|182775	PRK10847, PRK10847, DedA family protein.	1.6799e-37
NZ_CP043006.1|WP_148389360.1|5612804_5614256_+|amino-acid-permease	gnl|CDD|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.16689e-133
NZ_CP043006.1|WP_148389359.1|5611154_5612534_-|cation:dicarboxylase-symporter-family-transporter	gnl|CDD|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	2.17763e-121
NZ_CP043006.1|WP_148389356.1|5608583_5609045_+|MarR-family-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	8.68063e-13
NZ_CP043006.1|WP_148389365.1|5621549_5622743_+|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|181036	PRK07568, PRK07568, pyridoxal phosphate-dependent aminotransferase.	0
NZ_CP043006.1|WP_148389363.1|5617332_5618259_-|DnaJ-domain-containing-protein	gnl|CDD|237667	PRK14299, PRK14299, chaperone protein DnaJ; Provisional.	5.56558e-68
NZ_CP043006.1|WP_148389355.1|5607925_5608507_+|polyisoprenoid-binding-protein	gnl|CDD|225228	COG2353, COG2353, Uncharacterized conserved protein [Function unknown].	4.20403e-61
NZ_CP043006.1|WP_148389370.1|5627539_5628535_-|DNA-directed-RNA-polymerase-subunit-alpha	gnl|CDD|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	6.29704e-154
NZ_CP043006.1|WP_148389361.1|5614484_5615195_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator	gnl|CDD|237084	PRK12378, PRK12378, YebC/PmpR family DNA-binding transcriptional regulator.	5.58133e-118
NZ_CP043006.1|WP_148389352.1|5605467_5605968_+|redoxin-domain-containing-protein	gnl|CDD|376354	pfam00578, AhpC-TSA, AhpC/TSA family. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).	6.7605e-06

Protein sequences

>NZ_CP043006.1|WP_148389361.1|5614484_5615195_+|YebC/PmpR-family-DNA-binding-transcriptional-regulator
MGRIFEVRKHTMFARWDRMAKQFTRIGKEIAIAVKQGGPDPDNNPALRRCYQNAKGVNMPKDRVEAAIKRAMGKDITNYEEVVYEGYAPHGVAVMVETATDNPTRTVANVRMHFNKCGGSLGNSGSVGFMFNRLGVFKIKNEGQNLEELELELIDFGLEEIGEDSEGNIIIRATFTEFGNMAKALEDKGITPISADLQRIPATTVELGEEQAKEVLELIDRLEQDEDVQQVFHNLK
>NZ_CP043006.1|WP_148389360.1|5612804_5614256_+|amino-acid-permease
MSRLFAKKSLSILLNEASDSEKGLKRTLSSPALVALGIGAIIGAGLFSLTGIAAAENAGPAVTISFVLAAVGCAFAGLCYAEFASMIPVAGSAYTYSYATMGEFIAWIIGWDLVLEYALGAATVAVSWSRYLMEFLQKFDIHIPHQLAVSPWETVTMSNGTVVEGGIFNLPAVIIVLLLSLLLIKGTRESAGMNNFLVILKVAVVLVFIILGWSHIDPANYEPYIPANTGQYEHFGWTGIASGAAVVFFAFIGFDAVSTAAQEAKNPQKGMPIGILGSLVVCTILYVLFAHVMTGLLNYKLFAGDAKPVATAFAQTGYDFLQTGLIVAILAGYTSVMLVMLMGQSRVFYSMSRDGLLPKFFSDVHPKFRTPWKTNIFFMVFVSLFAGLVPVSDLGHMVSIGTLFAFSLVCIGVIIMRKKMPEIPRAFKTPFVPVVPILGVVVCVYLMYSLPNESWLRLAVWLALGLLIYFTYSRKNSKLNKEK
>NZ_CP043006.1|WP_148389359.1|5611154_5612534_-|cation:dicarboxylase-symporter-family-transporter
MTKKQAALIALILFTLVAILHTLDHFNLVGIAGPVLMVARWIAVAGVVWFAVKKRSLTTWILVSMVIGGELGHDYPGIAVQFQVLSKVFLQLIKTVIAPLLFATLVVGIAGHSDIKQVGRMGWKSLLYFEIVTTIALFIGLAAINISKAGEGIPMPPEALHEKLPETKPQSWQDVILHIFPENIAKSIYHGEILPIVVFSVIFGIALLLVKDKFRGPMLGFCESLSEVMFKFTNIVMYFAPVGVGAAIAYTVGHGGLSVLGNLLQLLITLYVALFVFVLLVFVPVALIIGLPIRRFIKEISEPVSIAFATTSSESALPKAMEAMERMGVPRKVIAFVMPTGYSFNLDGSTLYLALASVFVAQAAGIQLSIWEQLLMVFTLMLTSKGVAGVPRATLVIILGTVASFHLPVWPVFLILGIDELMDMARTSINVIGNCLATAVIGKWEGEVDFKALPPETKA
>NZ_CP043006.1|WP_148389358.1|5610370_5611072_-|DedA-family-protein
MDQIIEFFKHLINPEWIINNGGFYLILAIIFAETGLFVGFFLPGDSLLFIAGIYGEKLGESFFNMPLLVIMTLIATTGVLGNMVGYWFGRKSGPILFKRKDTFFFKKKHLWQAKEVYDKYGGGAIFVARFLPVVRTFAPIVAGIVAMERKKFMFWNIIGSFSWVFSMMLAGHYLDKAFPTLKDHLEWIIVIIVVITTIPVAAKFIFGKSTIHSHFDEFGNPIEQPVKQEEKES
>NZ_CP043006.1|WP_148389357.1|5609038_5610295_-|MFS-transporter
MNSTKPVKLLNAAVIVASLGYFVDIYDLLLFGIIRIKSLTSLGLSGQEIDTVGMWLINIQMTGMLIGGVIWGVLGDKKGRLSVLFGSILLYSVANIANGMISGDNAIGWYMIWRFVAGLGLAGELGAGITLVSEILPKEKRGLGTMIVASVGISGAVAAYFVSEYFGDNWRVCYYIGGALGLALLILRVSVAESGMFNTIKERNVSRGNYLLFFTSRERFFRYLKCILIGLPTWYAVGILVTFSNAFATKMGVQGNIDPGKAIMICYAALTVGDFASGYLSQLIRSRKKVLYIFYTLLCGAVVLYFNAHGVSAAAFYTICGLIGFSVGFWAIFVTVAAEQFGTNLRATAATTVPNFARGLLPLISIVFGGLQTAFGLSYLQSGFVTGILCICLAFAAAFMMTETFGKDLDYVEESPGQ
>NZ_CP043006.1|WP_148389356.1|5608583_5609045_+|MarR-family-transcriptional-regulator
MSNIEKLISIKTFTSEHHKGLISLIFVGNWIISKHQQFFKQYDITMQQFNILRILRGQHPKAASINTLKERMLDKMSDVSRLVERLRKAGLVERKNSEMDRRAVDVMITAKGLELLRVIDDQIGILESTLKDNLNEKEVVQLNRLLDKMLDAY
>NZ_CP043006.1|WP_148389355.1|5607925_5608507_+|polyisoprenoid-binding-protein
MKTLLLAAWICSPLSVSAQAATWKVDRDHSSVNFSVEHLVISEVDGSFRNFDGTIISSRPDFSDARVNFTIVVSSINTGNDPRDNHLRSDDFFNAEQYPEMTFKSTALTRTADGKYLMEGDLTIRDVTKSIKFNVAYGGTAKDSEGRQRAGFKANTYLNRFDYGLKWDKMTEAGGMVVDKMVNIELKLEFIKQ
>NZ_CP043006.1|WP_148389354.1|5607193_5607721_+|hypothetical-protein
MPFYLKYAFTYKLPDDSGFSAIVNADKYPSFVKRDWHFNDLKQHFTEAMNNETLIIWGTGMEGDWSVKFVEQPSPQQAFREFQKIIRVTTGGLYLTNYEDLTLAAQFEDRKIPAMHRSDLFVPMNNGRYNLTIRQMFHPGSSYAALAGQINFEVVVQKAPENGVQKVESIFWCEQ
>NZ_CP043006.1|WP_148389353.1|5606087_5607026_+|malate-dehydrogenase
MKVTVVGAGNVGATCANVLAHRDFLQEVVLLDIKEGTAEGKALDTWQQAPIDYYSTKVTGVTNDYAKTAGSDVVVITSGLPRKPGMSRDDLISTNANIVKSVTENVTKYSPDAIIIVVSNPLDVMTYCAFLNAKKDSSKVFGMAGILDTARYRAFLADEIGCSPKDIQAILMGGHGDTMVPLPRFTTVAGIPVTDLVAKDKLEAIIQRTKVGGGEIVNLLGTSAWYAPGAAAAQMVEAILKDEKRIFPVCAWLTGEYGLKDIYLGVPVVLGKNGIEKIIELNLNSDEKALLATSATHVKEVMEVLDNMKTPA
>NZ_CP043006.1|WP_148389352.1|5605467_5605968_+|redoxin-domain-containing-protein
MMRRWMFLFLCLPALLKAQSNTNSTTAVPPYKQYSIISPAPLTLYDGHVITKNDLPRNRPVIVFLFSVECDHCAHMTEEILQNIDKFKQATLLMVTPFKPDRMKAWYDQYNIGKYPGIIMAAEPTRQIVYYYDLENFPGVYIYDKKHKLVADYEGTVKLETLLKHL
>NZ_CP043006.1|WP_148389362.1|5616524_5616776_-|hypothetical-protein
METRCIRCSNIVHSHKKISETRCKCGGQLQRMRFIRLIEGMHPLGKEHNIELNGKLCYGTYRSVYGNFIIDRVNNTFKRVDMS
>NZ_CP043006.1|WP_148389363.1|5617332_5618259_-|DnaJ-domain-containing-protein
MEYKDYYKILGVDKKASAADIKKAYRKLAVKYHPDKNPDDKLAEEKFKELNEAYEVLGDEEKRKKYDEFGENWKYYEQAGQNTGDFDWSRWRGQGGGQQQYEDVFGEGGQFSDFFEHLFGGGFRRSGQQQGRARNRKGADLHASMQVALEDVFTGATKQIEVNGQRLNLKIKPGTYQGQVLRLKGKGYLGRNGGEAGDLLLEIGIAADPRYELKGKDVHLELPLDLYTAVLGGKLPVAVPGSTLQLSIPAGTDGGRLFRLKGKGLPAPEGSGEAAGDLYVRVRITVPQNLSEEELQLFTRLSKMRKSS
>NZ_CP043006.1|WP_148389364.1|5621043_5621445_+|DUF1573-domain-containing-protein
MKKFILSLFASLLITTAVWAQAQGSGSTNAVDLKVKFKQETVDFGTTKFNKPVTVTFEFTNISKAPVLIESAKASCGCTVPNWTVEPVLPGKSGKITATYSANAVGKPTKTVYLKLKGVDQEKELILTGTVEN
>NZ_CP043006.1|WP_148389365.1|5621549_5622743_+|pyridoxal-phosphate-dependent-aminotransferase
MPNISQRGQVMPPSPIRKLVPYAEAAKKKGVKVYHLNIGQPDIETPRPVLDAVRQSEFTILEYSHSAGNESYRRKLTGYYKKFDITVDHTEIIVTTGGSEAILFGLMACLDPGDEVIIPEPFYANYNGFAVEAGVKVVPVTATIDNGFALPPIGDFEKLITPRTRAILICNPNNPTGYLYSPAEMEILKDICLKHNLFLFSDEAYREFCYDGQNISALNLSGMENHVVIFDTISKRYSACGGRIGAIVTHNRAILDSVMKFAQARLSPPSFAQIAAEAAVDLPDDYFDGIKAEYQSRRDLLVDLLNKIPGVYCPNPGGAFYAIARLPIDDADRFCQWLLESFVYEQQTVMLSPATGFYATPGLGLQEVRLAYVLNRESIASAMEVLAKALEVYPGKQ
>NZ_CP043006.1|WP_148389366.1|5623946_5625089_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MPQTTRSTQPAILLLEDGTVFHGKAFGKIGTAAGELCFNTGMTGYQEVFTDPSYKGQVLIMNNCYVGNYGTKKEDVESSDVKISGLICKNIAYNYSRKMADESLEQFLAGNNLVAIHEVDTRALVSHIRSKGAMNCIISSEILDEAELKARLNKVPSMEGLALCAEVSTKEPYFVGDPNADIRIAVLDNGVKRNMLKCLSEKGAYLKVHPTATSFEECETFQPHAYFISNGPGDPAPLAYAVDTIKKVLDAERPLFGICLGHQLLAMANGIPTYKMHHGHRGLNHPVKNLLTGKCEVTTQNHGFAIDAKAVAASQNVEVTHINLNDNSVEGIRIKGKPAFSVQYHPESTPGPHDSRYLFDDFFTMIKADMKKVKEKAATA
>NZ_CP043006.1|WP_148389367.1|5625184_5625991_-|hypothetical-protein
MYYLKCGHCAAYSSLKSEYITFCDHCGKKLPVSYADWKARHPREDFDAFRKAEGISAAEYQAIMKKQYRRAFDMRKTAALITGLVVLLTFSALGAYYGPALVKMLREPAVSPALLEASNWRTFRGNVIRLQTPFSLSPVNARETPGMRIKTFKGGSRADGLVIQMQEAVHLSDPDIELASAAGELAEMLSNLPNTSRFTMKEQLLDVSGQRAIWQHGTYVYQQTVEMEFNSLVVVKGGTRVQVLVTHRGQDRNGREVAGKVMQSARLN
>NZ_CP043006.1|WP_148389368.1|5626035_5626851_-|hypothetical-protein
MYSLKCNHCGHANALKSEYVTFCASCSKKMANNYSDWKLRNPAGDFASYCEAVGVTANEAAGGKSVKKKRFYWDRRKVVIGVAAILVSSIAGLLVERSVKMFGGKVPEEWMTREWKPFSTPRGIAEFLIPIELKSFTLPFPPEAAQFLAWAESCQSDSSMPIQVLASELEYRPEVQVSLQGGADGGINAARNKPGISDFDYEEVDVEISGQKAIRQSGKYRVRLFQRCFFRSIYILKEQHLVQVVVIYAAKDAVAEKVAERIINSVKLKNI
>NZ_CP043006.1|WP_148389369.1|5626926_5627430_-|50S-ribosomal-protein-L17
MRHGVKLNRLSRTSAHRKSLMSNLAIELISHKRIQTTLAKAKALRVYIEPLLTRAKTDDTHNRRIVFSYLQDKEAIKELFGVISEKIASRPGGYTRIIKLGKRVGDNAEVALIELVDFNEIYGKSATEEKAPAKKTRRAGGGKKKAEEKTEAAAPEAPAAGEVPAAE
>NZ_CP043006.1|WP_148389370.1|5627539_5628535_-|DNA-directed-RNA-polymerase-subunit-alpha
MAILNFQKPDKIVLQKSTDFEAQFEFRPLEPGYGVTIGNALRRVLLSSLEGYAIVGIKIEGADHEFATLKGITEDVTEIILNLKQVRFKKIVEQEVGSEKIQISIKGKTEFRADMIEKATNSFQIMNPELLICTLDPSAKLDIELTIGKGRGYVPAEENRPKDAIFGYIAIDSVFTPIKNVKYSIENTRVEQKTDYEKLIMEVITDGTIHPEEAVKQASRILIQHLMIITDENISFDTKDTEKEDVVDEQTLQLRKILKTPLEDLDLSVRAFNCLKAAKINSLSELVQYEQEELMKFRNFGQKSLSEIEQVLGERGLHFGMDLSKLKLDEE
>NZ_CP043006.1|WP_148389371.1|5628610_5629216_-|30S-ribosomal-protein-S4
MARYTGPKTKISRIFGEPILGNGKYLGKNSNPPGQHGAQRKRKQLGEYALQLREKQKAKYTYGLLEKQFRNLFDEANRRKGVTGEVLIKLLEARLDNTVFRMGIAPSRPAARQLVAHKHVTVNGVVVNIPSYQLQPGDVIGLKDKTAGNTSLTSNIRGKNPKFSWLDWNEKDMKGVFIAYPERESVPENIKEQLIVELYSK

Crispr_ID: NZ_CP043006_14

• CRISPR_ID: NZ_CP043006_14
• CRISPR_location: 5669919-5670061
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_14

Consensus_repeat	Method
TTCATCCGTTTAAGTTTTAATTTTTACGGGCCGGATGGAGCCT	CRISPRCasFinder

spacers of NZ_CP043006_14

>14.1|5669962|57|NZ_CP043006|CRISPRCasFinder
CAGATGTTTGGCATAATCATTTTCCGTGTGTTTAATGATTATGCCAAACATGCCGGA

CRISPR arrays and Neighbor proteins around NZ_CP043006_14

CRISPR arrays

The CRISPR arrays of NZ_CP043006_14

>merge|NZ_CP043006|14|5669919-5670061|CRISPRCasFinder
TTCATCCGTTTAAGTTTTAATTTTTACGGGCCGGATGGAGCCTCAGATGTTTGGCATAATCATTTTCCGTGTGTTTAATGATTATGCCAAACATGCCGGATTCATCCGTTTAAGTTTTAATTTTTACGGGCCGGATGGAGCCT

>NZ_CP043006|14|11|5669919-5670061|CRISPRCasFinder
TTCATCCGTTTAAGTTTTAATTTTTACGGGCCGGATGGAGCCT	CAGATGTTTGGCATAATCATTTTCCGTGTGTTTAATGATTATGCCAAACATGCCGGA
TTCATCCGTTTAAGTTTTAATTTTTACGGGCCGGATGGAGCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148389409.1|5664450_5665869_-|glycoside-hydrolase-family-125-protein	unknown	unknown	gnl|CDD|377716
NZ_CP043006.1|WP_148389414.1|5674968_5678322_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
NZ_CP043006.1|WP_148389413.1|5673468_5674941_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|333750
NZ_CP043006.1|WP_148389404.1|5658906_5659497_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl|CDD|237823
NZ_CP043006.1|WP_148389406.1|5659908_5660478_+|nitroreductase	unknown	unknown	gnl|CDD|380312
NZ_CP043006.1|WP_148390052.1|5666015_5667275_-|MFS-transporter	unknown	unknown	gnl|CDD|340886
NZ_CP043006.1|WP_148389417.1|5680521_5681124_+|mobile-mystery-protein-B	unknown	unknown	gnl|CDD|131662
NZ_CP043006.1|WP_148389415.1|5678416_5679652_-|exo-alpha-sialidase	unknown	unknown	gnl|CDD|271234
NZ_CP043006.1|WP_148390054.1|5670140_5671100_-|N-acetylneuraminate-lyase	unknown	unknown	gnl|CDD|188641
NZ_CP043006.1|WP_148390051.1|5662153_5663650_-|glycerol-kinase-GlpK	unknown	unknown	gnl|CDD|198361
NZ_CP043006.1|WP_148389418.1|5681229_5681916_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225097
NZ_CP043006.1|WP_148389407.1|5660483_5662025_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223651
NZ_CP043006.1|WP_148389411.1|5671118_5672273_-|exo-alpha-sialidase	unknown	unknown	gnl|CDD|271234
NZ_CP043006.1|WP_148390053.1|5667297_5668344_-|galactose-oxidase	unknown	unknown	gnl|CDD|274642
NZ_CP043006.1|WP_148389419.1|5682004_5682511_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380376
NZ_CP043006.1|WP_148389412.1|5672286_5673453_-|exo-alpha-sialidase	unknown	unknown	gnl|CDD|271234
NZ_CP043006.1|WP_148389408.1|5663662_5664013_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NZ_CP043006.1|WP_148389416.1|5680069_5680531_+|mobile-mystery-protein-A	unknown	unknown	gnl|CDD|274231
NZ_CP043006.1|WP_148389405.1|5659483_5659912_+|thioesterase	unknown	unknown	gnl|CDD|372545
NZ_CP043006.1|WP_148389403.1|5658393_5658891_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148389409.1|5664450_5665869_-|glycoside-hydrolase-family-125-protein	gnl|CDD|377716	pfam06824, Glyco_hydro_125, Metal-independent alpha-mannosidase (GH125). This family, which contains bacterial and fungal glycoside hydrolases, is also known as GH125. They function as metal-independent alpha-mannosidases, with specificity for alpha-1,6-linked non-reducing terminal mannose residues. Structurally this family is part of the 6 hairpin glycosidase superfamily.	0
NZ_CP043006.1|WP_148389414.1|5674968_5678322_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043006.1|WP_148389413.1|5673468_5674941_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|333750	NF033072, NanU, SusD family outer membrane lipoprotein NanU. NanU, related to SusD and RagB, is an outer membrane lipoprotein from a TonB-dependent nutrient uptake complex.	2.28558e-52
NZ_CP043006.1|WP_148389404.1|5658906_5659497_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl|CDD|237823	PRK14823, PRK14823, putative deoxyribonucleoside-triphosphatase; Provisional.	7.60369e-95
NZ_CP043006.1|WP_148389406.1|5659908_5660478_+|nitroreductase	gnl|CDD|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	2.14176e-54
NZ_CP043006.1|WP_148390052.1|5666015_5667275_-|MFS-transporter	gnl|CDD|340886	cd17328, MFS_spinster_like, Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters. The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.17939e-49
NZ_CP043006.1|WP_148389417.1|5680521_5681124_+|mobile-mystery-protein-B	gnl|CDD|131662	TIGR02613, cell_filamentation_protein, mobile mystery protein B. Members of this protein family, which we designate mobile mystery protein B, are found in mobization-related contexts more often than not, including within a CRISPR-associated gene region in Geobacter sulfurreducens PCA, and on plasmids in Agrobacterium tumefaciens and Coxiella burnetii, always together with mobile mystery protein A (TIGR02612), a member of the family of helix-turn-helix DNA binding proteins (pfam01381). This protein is encoded by the downstream member of the gene pair and belongs to the Fic protein family (pfam02661), where Fic (filamentation induced by cAMP) is a regulator of cell division. The characteristics of having a two-gene operon in a varied context and often on plasmids, with one member affecting cell division and the other able to bind DNA, suggests similarity to addiction modules.	8.91324e-81
NZ_CP043006.1|WP_148389415.1|5678416_5679652_-|exo-alpha-sialidase	gnl|CDD|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	8.83966e-79
NZ_CP043006.1|WP_148390051.1|5662153_5663650_-|glycerol-kinase-GlpK	gnl|CDD|198361	cd07786, FGGY_EcGK_like, Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of mostly bacterial and archaeal glycerol kinases (GK), including the well characterized proteins from Escherichia coli (EcGK), Thermococcus kodakaraensis (TkGK), and Enterococcus casseliflavus (EnGK). GKs contain two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The high affinity ATP binding site of EcGK is created only by a substrate-induced conformational change, which is initiated by protein-protein interactions through complex formation with enzyme IIAGlc (also known as IIIGlc), the glucose-specific phosphocarrier protein of the phosphotransferase system (PTS). EcGK exists in a dimer-tetramer equilibrium. IIAGlc binds to both EcGK dimer and tetramer, and inhibits the uptake and subsequent metabolism of glycerol and maltose. Another well-known allosteric regulator of EcGK is fructose 1,6-bisphosphate (FBP), which binds to the EcGK tetramer and plays an essential role in the stabilization of the inactive tetrameric form. EcGK requires Mg2+ for its enzymatic activity. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	0
NZ_CP043006.1|WP_148389418.1|5681229_5681916_-|GntR-family-transcriptional-regulator	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	1.52036e-34
NZ_CP043006.1|WP_148389407.1|5660483_5662025_-|FAD-dependent-oxidoreductase	gnl|CDD|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	3.25859e-165
NZ_CP043006.1|WP_148389411.1|5671118_5672273_-|exo-alpha-sialidase	gnl|CDD|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	2.55201e-101
NZ_CP043006.1|WP_148390053.1|5667297_5668344_-|galactose-oxidase	gnl|CDD|274642	TIGR03548, mutarot_permut, cyclically-permuted mutarotase family protein. Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.	7.58637e-43
NZ_CP043006.1|WP_148389419.1|5682004_5682511_-|cupin-domain-containing-protein	gnl|CDD|380376	cd06121, cupin_YML079wp, Saccharomyces cerevisiae YML079wp and related proteins, cupin domain. This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.	2.3683e-75
NZ_CP043006.1|WP_148389412.1|5672286_5673453_-|exo-alpha-sialidase	gnl|CDD|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	3.56186e-113
NZ_CP043006.1|WP_148389408.1|5663662_5664013_-|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	3.45915e-20
NZ_CP043006.1|WP_148389416.1|5680069_5680531_+|mobile-mystery-protein-A	gnl|CDD|274231	TIGR02612, transcriptional_regulator, mobile mystery protein A. Members of this protein family are found in mobization-related contexts more often than not, including within a CRISPR-associated gene region in Geobacter sulfurreducens PCA, and on plasmids in Agrobacterium tumefaciens and Coxiella burnetii, always together with mobile mystery protein B, a member of the Fic protein family (pfam02661). This protein is encoded by the upstream member of the gene pair and belongs to a family of helix-turn-helix DNA binding proteins (pfam01381). [Unknown function, General].	1.51138e-40
NZ_CP043006.1|WP_148389405.1|5659483_5659912_+|thioesterase	gnl|CDD|372545	pfam13279, 4HBT_2, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	2.7106e-25
NZ_CP043006.1|WP_148390054.1|5670140_5671100_-|N-acetylneuraminate-lyase	gnl|CDD|188641	cd00954, NAL, N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL). N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL), which catalyses the reversible aldol reaction of N-acetyl-D-mannosamine and pyruvate to give N-acetyl-D-neuraminic acid (D-sialic acid). It has a widespread application as biocatalyst for the synthesis of sialic acid and its derivatives. This enzyme has been shown to be quite specific for pyruvate as the donor, but flexible to a variety of D- and, to some extent, L-hexoses and pentoses as acceptor substrates. NAL is member of dihydrodipicolinate synthase family that comprises several pyruvate-dependent class I aldolases.	7.04321e-100

Protein sequences

>NZ_CP043006.1|WP_148390053.1|5667297_5668344_-|galactose-oxidase
MTHTEAKYHWGTLPPVPDSTGFAGSFAGISNNALIVAGGANFPDGGTPWNGGKKTWYDQVFVLEQPGGPWKVAGKLPRPLGYGVSITTAGGLLCVGGSNAEGHYPDAFLLRYANGEIAITDLPPLPVPLANASGAMTDSCIYIAGGLSAPDATETEQVFYMLDLKEAEQLRAWHSLPPWPGPSRMLAVAGSLDSAFYLFSGAELQKGKRIYLKDAYRYHPVSGWEKCADLPRAAVAAPTPAFRYNGHMLSVFGGDTGEDADSAAVLREKHPGFADDIIAYDREENKWVQQGKVHTRMEEDAVAHPNNSIWAPVTAPAVVWNGMLVIPGGEVRPGTRTPNVLTAAVAAP
>NZ_CP043006.1|WP_148390052.1|5666015_5667275_-|MFS-transporter
MKDKKYYPWLVVALLWFVAMLNYLDRQMLSTMKPSIEGDISALESATNFGRLMAVFLWIYGLMSPISGMIADKLSRKWLIVGSLFVWSAVTLLMGFAQNFEQLYWLRALMGVSEALYLPAALSLIADYHGSKTRSLAVGVHMTGLYMGQALGGFGATIAAAYSWQATFHWIGLLGVVYAVVLILFLREKRPDAPGVADGGSREKVPLFKGVKGLLTLLPFWIILLYFAIPSLPGWAIKNWLPTLFAGSLHVPMSEAGPIATVTIAISSFIGVIVGGTMSDRWVQRNVRGRIFTSAIGLGLTIPALFLLGVEQSTYYLVASAFCFGFGFGMFDANNMPILCQFVAARYRATAYGLMNMAGVFSGAFITNFLGRSSDAGNLARDFAWMSVVIIAAVGMLLIFLKPKVKDFGEIVALRRDLP
>NZ_CP043006.1|WP_148389409.1|5664450_5665869_-|glycoside-hydrolase-family-125-protein
MIRRKFLQQSALLSSAVLLRPVLSWANTADFPVVRIPAAERKFRSEAVEKAIAAVKSKSGNQELAWLFENCFPNTLDTTVEYEMKNGRPDTYVITGDIDAMWLRDSTAQVSPYLPLVKEDKDLQHLIAGVINHQVKCIHKDPYANAFYKDENKRGEWATDLTDMKPGIHERKWEIDSLCYPIRLAYQYWKITGDTAPFDTAWKESIALTLKTFREQQRKDGPGPYHFQRKTSWATDGVPLAGYGYPVKPVGLICSSFRPSDDATIYNFLIPSNFFAVISLRQAAEMLQALQKDAALAGECRALATEVENALKQYAVVTHPQFGKVYAYEVNGFGSFNLMDDANVPSLLSLPYLGAIKPNDPVYANTRKLILSSENPFFFSGKAAKGIGSPHTGVDRIWPISITMQGLTSNNEAEIRQCLQTLQKCHAGKGFMHESFHQDDPAEFTRSWFAWANTLFGEFVWKVFNERPHLLK
>NZ_CP043006.1|WP_148389408.1|5663662_5664013_-|PadR-family-transcriptional-regulator
MENKPNAYFITRWQSQIKKGLFEYIIMLLLQKKERYGYELISEIKQMADMDIAEGTIYPLLSRLKKEKLVDSRWVEMDEGVPRKYYKLTELGNEYLETMYQYLGELMQAIADLKNV
>NZ_CP043006.1|WP_148390051.1|5662153_5663650_-|glycerol-kinase-GlpK
MNGQKKYILSLDLGSSAAGAVLFSRQGQVVMQVQKEYEKYYPQPGWIEVDPNEIWFTMLSAIEELIGRAGIQAAEIAGIGIASQRETTVIWDRSSGEPVYNAIQWQDRRTSKRCDEFRYQGFSSLIRRKTGLILDAYFSASKISWILDHIKDGRIRAEQGKLAFGTIDAWLVWKLTAGKTHVTDVTNASRTMLFNIHTLQWDEELLRLFNIPHQLLPDICSNSEIIAETEPSILEAVIPIAAMAGDQQAALFGQMCLEPGMVKNTYGSGCFALMNIGSKPIIPEQQLLTTVAWRIGGEVTYALEGSVFGGSSVFRWIRDGLGLIESTAEIEALAQTEPDNGGVLFVPALSGLGTPYWDPYARGMIIGITRGTTSGHIARAALEGVALGIADALEAMEKESGRAITALRVAGTSATYEFFMQMQTDILGYPVMRPKVMPASATGVAYLAGLATDFWTMEEVRAQYTIARVFEPNPPAPGQTVLREKWQKAIARVKNWDF
>NZ_CP043006.1|WP_148389407.1|5660483_5662025_-|FAD-dependent-oxidoreductase
MNRSEQLGTIERQQDWDVIVIGGGATGLGAALEATTRGYRTLLLEQSDFAKSTSSKATKLLHGGVRYLAQGDIALVREASIERGLLLKNAKHLSRNLSFIIPAYSWWEGIYYTIGLKLYDWMAGRLSLGRSVHISRKKTLEKLPGLKADRLSAGILYHDGQFDDARLAVNLMQTIFEQGGVALNYMKVKALQKNGNGQLSVVTAEDVETGKQYTLKAKGIINATGVFVDDILEMDNPDIKRSIVASQGVHLVLDRSFLPGDNALMIPKTSDGRVLFAVPWHNKIVVGTTDNPVKEISLDPVAMEKEINFILSTAQQYLAHPPSRKDVKSVWAGLRPLAKPEKSEKTKEISRNHKIMVSPSGLVTILGGKWTTYRKMGEDVVDKLEQVKQWPHKPSVTRELPVHGSAVKIGQDDPLYYYGSDAAAVKALGKEVLSESLGITDAQPVWAVRTEMAFTVEDVLARRTRALFLDSDEAVRIAPKVAAIMAGELGKDKHWEEQQVRSFRELAQTYQLS
>NZ_CP043006.1|WP_148389406.1|5659908_5660478_+|nitroreductase
MNIKEIIQLRRTVKPTSMNGKKIDDAVVQELLQLADWAPTHGLTEPWYFAVFGGDKVKTFCTDHAELYKAYTPAASYIPGNYEKLQTQGDLASHVIAICMKRGSNPKIPEVEEIAAVACAVQNIWLAATDQQIAVYWGSGGMTYTPAMQDYLGLRDEDKVLGFLYLGYSEEAPRPGRRLKPLDEKVKWM
>NZ_CP043006.1|WP_148389405.1|5659483_5659912_+|thioesterase
MARVKIDMPSAYGFSCIIPVRIGDVNYGGHVGNDAIVSILHESRLQYLASIGCTELDAFGTSMIMADLAVLYKGEGFYGDQLTVEITADELSSAGFDLFYRISTVRDGKNSVIAEAKTGMVCFDYEQRKVARLPEALKQKLI
>NZ_CP043006.1|WP_148389404.1|5658906_5659497_+|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MTLVFATNNDNKVREIRSMLGDAFHIVTLQEAGIDIDIPEPHDTLEANALEKSATIHRMTGKNSFSEDTGLEIDALNGEPGVLSARYAGEQKSAEDNMTKVLQLLENQPNRKARFRTVISLILEGQEYQFEGIAEGSILPARKGGKGFGYDPIFQPEGSTKAFAEMDLAEKNQFSHRGKAFRKLIDFLQQQQHGKS
>NZ_CP043006.1|WP_148389403.1|5658393_5658891_+|hypothetical-protein
MSLDRLQLDPYLLAQMYDQPIIPEEHRAQPAVAKALPKVKYLGENQKNILLLIQNESEAYLNDELFNLLANILNACKLGMQDVALINIALYPGLTLADYQQAVSARQCIIFAIPPAILGLPPMQPYLPETHGQVVAVHSDDLQLIATDKQLKGRLWQGLKQLFGI
>NZ_CP043006.1|WP_148390054.1|5670140_5671100_-|N-acetylneuraminate-lyase
MRIKGLIAATFSTFNEDGKLNLALIPALVEKLLQDGVKGVFICGTNGEGPNLTIEERMQIAEEFIKVVNKRCLVLVHVGHPSITEARKLAAHAQKIGADAISAVAAFYFKPRSVENLVDCMAEIASAAPEIPFYYYHIPVITGVAIDLLEFLRLGEEQIPNLAGIKYTASTLHEYQACLNYKDGKFDILYGYDELLLPALAVGAEGAIGSTYTFAAPLYLRVMEYFRQGKIAEARQMQFHAVRMIQCLSRYAPIPTQKSIMKILGMDLGPCRLPLTNLSAAEQQDISSYLDAIDFRNVLEAASSGLTPANGTVTSNMQV
>NZ_CP043006.1|WP_148389411.1|5671118_5672273_-|exo-alpha-sialidase
MEHKKFLALFFFAAALIGQACQSTKHAAGSTAEESVVVFEPDSVYASARIPALVMTKKQSLLAFCEGRIGSASDWADMNLVMRRSTDDGKTWSNIVIIDSNKKAPVGNPVPIVDDRGTVHLLYQKDYNEAFYTFSTDDGLTWSAPVNITQVYEDFRPRYDWKVLAPGPGHGIQLQNGRLLSAVWLANSAKLTPRRSHHPSCVTTIYSDDLGKTWKLGEMVADNSPEIANPNESMPVQLPDGRVLLSIRNPSPVKRRAFSTSSDGISNWSPARFEEELFDPVCMASIISVPAGKKGQQALLFINPDSRDIEKTPRKNLTAKLSFDNGETWPAQMVLDSGASGYSDVAVGKNGQVYCLYETNTNGNKGFNYSLVLKKFNVGQLLKK
>NZ_CP043006.1|WP_148389412.1|5672286_5673453_-|exo-alpha-sialidase
MKQSGIKKLISLLLIFHAASACNDDNNERIFPKLEAPGSVLPHVFQKGTEGYSCFRIPAIVMTKSGTLLAFAEGRKNDCSDEGDIDLVLKRSADTGKTWSKLSVVWSDGENTCGNPSPVIDQATGKIHLLMTWNKGEDDIGKINAGTSVDTRRVYLTASSDDGLSWDAPKEITSTVKQSNWGWYATGPCHGIQVAEGPHKNRMIVPCDYIEVGAGRRGNSHIIYSDDAGASWELGGIVPVVPGLNPNESTIAELPGGKLILNMRVGNNNNQRLSSTSTDGGMTWTPPVQEPSLTDPVCQGSLLNATINGTFMLFFSNPASTTRTSMTIKLSMDEGLTWSKKKQVFNGPSAYSDLVLLSDEKVGLFYEAGVGHYNGGIAFKSVAITDIK
>NZ_CP043006.1|WP_148389413.1|5673468_5674941_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKRLFLNILMVAFSASVISGCDAILDVKPQSSITEQVFFKNESDFEPNVVGIYTVLRSLANNVTYGTERGEELISASNSRFTVAWSHTLSPSSGAINYAEWYRGIGHCNLLLDKIQDFSFSSNPDLKKKILAEAYALRAFFYFHLIRVIGDAPIMLEAVVDENVPLLSRSPAADVMEQIQLDLDASIAQFTSMTQFSKSSYPSKYRFAYGSVQALKADALLWSAKVLGGGNADLEKAITAINEIEATGLDLNDDFTDVSGVRAAGNKEVLMAAYYQRDETPGGNYAKNALPFLSIVQGALNLDQIPYAVSSGNGQGAYQISPLSRSLFTNPADKRIPGTWVLEMQATGPKVSWITKYPGTKYADDRIPDNDLILYRLADVYLMKAEAYAAMSDIPNSVEYLDKVRDRAETGAYTGSMNKADVEREILNERGRELFFENKRWFDLVRFHLGGTIDVYTYVPNLAGKTTPLFWPLNTTVFANNPNIGQTDGY
>NZ_CP043006.1|WP_148389414.1|5674968_5678322_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MTLFRFCCFFLFLFGMHECYSQTPGFTVRGSVRDSANNEPLIGVSISVKGNPTKGTVTNSEGRFSLQVATGNEVLQVRMMNYATKEIPVNKVAEHNIVLSESFSELGEVLIVGYTEQSTKKNTAAISRLDVAELKNNPNPNPVQALQGKVAGVSIPITQGQPGIGATNIIIRGGTKPNVYGSGLGNNNGASVGASEGSNPLVVVDGVFRSINDVNPDDIESMQVMKDAASTAIYGARGANGVIVIKTKRGKLNSRSSITLSHRTTWETQARDYDYLSAEEYLRLARITVANTSDNIDKNNLLYNGGFSAGTRIYTRPGDYGKNVYLTALYDNIMQVEGADYVNNLLANGWRVMDDPINPGTKLLYADNNYQDMLWKTGVSNTENVTLSGGTDKADYNFSMGYTDQKGILVGTAYKRYNALGNFGYQASENLKLDFMVNYQQVKPNYVDAYQNDLVRGVRITPLIRIFKDDGNPAPGELYTVRNRFHTLKYDEMRTSTERMVTRVAADLKIIKGLHFKPSLSYVIDDYTELFMRKATPQDEIQPSMQRWKDDYTNNSRQLMIDQVLQYDFSVQKDHNFSVLAGVNYTRNTNHVKDMGSQRATNDYIFTIDEPTTTNINGSVFSNVVDFATNLGETRSASMFGQFSYDYKMKYLLGGSLRYDGFSNFAPDNKYAFFPSLSAGWNIDREDFWKPNNVVSGLKLRGSWGAAGLSGLSLADTYGRYSAVSYGMYAGILRSGLSNPNLVWESTVTTDLAVDASFFRNRINLSVDYYNKLTKDRLTSKPLPSESPFTSIAYNNGELQNRGIEVAIGGTVVQTASFNWHANFSFAFNRTTITKLPDNGRLKNRQGGDIVFDKNTGKEMEAGGLAEGERPYAIYAYNVLGVFASDEEAAEWNSRIKDNLASPQGIIVGKKGGDFIFEDVNNDGVIDSKDQVFMGYRNPDKMGGIQNTFTYKGFSLRVNADYALGHLISNGALARSMGQGRAFNEGAPSQALGSDVWKNQGDQGKKYARFSFADYDFGQRNYLRNGSLGNNSSYNSDVSVMFEKGDFLALREITLSYDFPSAITSKFRATGLNVFASVYNVGFLTAYQGLNPEIYSGFDPGGYPRPRQYSLGANLKF
>NZ_CP043006.1|WP_148389415.1|5678416_5679652_-|exo-alpha-sialidase
MKFTYQSTAGCSLLAAALFLLPACTKKLEQNTRIGLEDESMSVVAAAAAPQSHSYLKLFDGGPSGQHSFRIPSIVKTRNGTLIAMCECRRWNNSDWGDINVVFKRSFDNGATWTQMGEIAASGNGTWGNPTSVYDPAQGSNGRVWVFLSWNDGTHTSMSTIDSWGDRKVYSCYSDDHGATWSAPVDRTSTLLPPGYAWDAMGPGIGIVTQFNNPGRLIIPALRRNIYSDDHGATWQYQLIPGGTDEGTIIERMNGTLMRNDRPTTSQWEASKRRRISTGTIEGGFSSFTSDGTLLDPKCQGSILRYNTDSPNRIVFLNSASTVTRGKMRVRISYDNGQTWPISRRIYDWLTEAQAQAQGKGGYSSMIKTADYHVGALIEINEDTGNNSTSHRSIEFHKFNLPWMLNGNPEP
>NZ_CP043006.1|WP_148389416.1|5680069_5680531_+|mobile-mystery-protein-A
MKLQNSLLVIRQLDKKMEGLQPLQGFSMPQDGWIRTIRKTLQMSLRQLGKRMSMTPQSVLEVETREKEGSITLKSLREAGEALNMTLVYGFLPKDGSLEKMIEWHARELALKIIYRTSTTMKLEDQENSSVRLNQAVEEMMEELKREPKKLWD
>NZ_CP043006.1|WP_148389417.1|5680521_5681124_+|mobile-mystery-protein-B
MGLAVEYQDGQTPLDEDEKEGLLIPSVTTRGELDEVEQRNIEEAIRWTVQRRKKFTANEVLTEAFVQELHVKMLGEVWRWAGSFRNSNKNIGVDKYQIGIELRILLDDCKYWMDNNIYGSDEIAIRFKHRIVSIHCFANGNGRHSRLIADVIIEKIFGGEVFTWGRQNLVSHNEYRALYLAALRAADRGDFEPLIRFARS
>NZ_CP043006.1|WP_148389418.1|5681229_5681916_-|GntR-family-transcriptional-regulator
MVNGIKPLSSKSMAERVETSLREYFARESFKPGDPLPTELELAAALGVSRNVVREALSRFKMLGIIETKKKTGMVISNPDIVGTFEKVLNPEIMDEATLQDLFELRLVLETGIADLLFIRKTKKDLDELEEIAAREVKGNNFRISNEIAFHGKLYEMTGNNTLKRFQTLLLPIFGYVMKLENKKYISGKVTHQGLVKILREGTPEEFKQGMVSHLQPHFDRVRKLKKP
>NZ_CP043006.1|WP_148389419.1|5682004_5682511_-|cupin-domain-containing-protein
MKNTTAEYWKQQLQLTSHVEGGAFRETYRAPLTIGHQALPAGFSGPRNASTGIYFLLEDGDFSAFHRIAADEMWHFYDGTTLYIYEIRPDGDLQVHKLGRNPEQGEQLQLVIPAGSWFASCVEETGGFALAGCTVAPGFDFADFELADRAALSALFPQHKGLIALLTR

Crispr_ID: NZ_CP043006_15

• CRISPR_ID: NZ_CP043006_15
• CRISPR_location: 5923952-5924057
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_15

Consensus_repeat	Method
ATGGCGCGTAGTAATTGATGTCTGATCTGTAAAAAAGG	CRISPRCasFinder

spacers of NZ_CP043006_15

>15.1|5923990|30|NZ_CP043006|CRISPRCasFinder
GATACCTTTTACGATCGCTTGCCATGATCC

CRISPR arrays and Neighbor proteins around NZ_CP043006_15

CRISPR arrays

The CRISPR arrays of NZ_CP043006_15

>merge|NZ_CP043006|15|5923952-5924057|CRISPRCasFinder
ATGGCGCGTAGTAATTGATGTCTGATCTGTAAAAAAGGGATACCTTTTACGATCGCTTGCCATGATCCATGGCGCGTAGTAATTGATGTCTGGTCTGTAAAAAAGG

>NZ_CP043006|15|12|5923952-5924057|CRISPRCasFinder
ATGGCGCGTAGTAATTGATGTCTGATCTGTAAAAAAGG	GATACCTTTTACGATCGCTTGCCATGATCC
ATGGCGCGTAGTAATTGATGTCTGGTCTGTAAAAAAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_148389609.1|5934878_5936099_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|99738
NZ_CP043006.1|WP_148389606.1|5932511_5933516_+|beta-ketoacyl-ACP-synthase-3	unknown	unknown	gnl|CDD|236475
NZ_CP043006.1|WP_148389594.1|5909259_5910369_+|DNA-protecting-protein-DprA	unknown	unknown	gnl|CDD|223829
NZ_CP043006.1|WP_148389598.1|5914473_5917059_+|PKD-domain-containing-protein	unknown	unknown	gnl|CDD|372639
NZ_CP043006.1|WP_148389605.1|5931832_5932420_-|Holliday-junction-branch-migration-protein-RuvA	unknown	unknown	gnl|CDD|234645
NZ_CP043006.1|WP_148389601.1|5920340_5921549_-|exo-alpha-sialidase	unknown	unknown	gnl|CDD|271234
NZ_CP043006.1|WP_148389611.1|5936555_5936930_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148389603.1|5924066_5924489_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148389607.1|5933584_5934280_-|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|223979
NZ_CP043006.1|WP_148389596.1|5912049_5913684_+|apolipoprotein-N-acyltransferase	unknown	unknown	gnl|CDD|143595
NZ_CP043006.1|WP_148389597.1|5913664_5914468_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP043006.1|WP_148389610.1|5936105_5936552_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP043006.1|WP_148389604.1|5924539_5931796_-|cell-surface-protein-SprA	unknown	unknown	gnl|CDD|275042
NZ_CP043006.1|WP_148389595.1|5910449_5911925_+|IMP-dehydrogenase	unknown	unknown	gnl|CDD|376340
NZ_CP043006.1|WP_148389608.1|5934321_5934816_-|hypothetical-protein	unknown	unknown	gnl|CDD|225200
NZ_CP043006.1|WP_148389600.1|5919129_5919888_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187604
NZ_CP043006.1|WP_148389599.1|5917186_5919118_+|T9SS-type-B-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|372639
NZ_CP043006.1|WP_168208960.1|5920095_5920257_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP043006.1|WP_148389612.1|5936989_5937898_-|ACP-S-malonyltransferase	unknown	unknown	gnl|CDD|223408
NZ_CP043006.1|WP_148389602.1|5921554_5923828_-|TonB-dependent-receptor	unknown	unknown	gnl|CDD|238657

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_148389609.1|5934878_5936099_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl|CDD|99738	cd00614, CGS_like, CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.	9.39638e-161
NZ_CP043006.1|WP_148389606.1|5932511_5933516_+|beta-ketoacyl-ACP-synthase-3	gnl|CDD|236475	PRK09352, PRK09352, beta-ketoacyl-ACP synthase 3.	1.77893e-175
NZ_CP043006.1|WP_148389594.1|5909259_5910369_+|DNA-protecting-protein-DprA	gnl|CDD|223829	COG0758, Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion].	1.69549e-100
NZ_CP043006.1|WP_148389598.1|5914473_5917059_+|PKD-domain-containing-protein	gnl|CDD|372639	pfam13585, CHU_C, C-terminal domain of CHU protein family. The function of this C-terminal domain is not known; there are several conserved tryptophan and asparagine residues.	6.0517e-21
NZ_CP043006.1|WP_148389601.1|5920340_5921549_-|exo-alpha-sialidase	gnl|CDD|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	3.37264e-09
NZ_CP043006.1|WP_148389605.1|5931832_5932420_-|Holliday-junction-branch-migration-protein-RuvA	gnl|CDD|234645	PRK00116, ruvA, Holliday junction branch migration protein RuvA.	2.62971e-68
NZ_CP043006.1|WP_148389607.1|5933584_5934280_-|NUDIX-domain-containing-protein	gnl|CDD|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	3.4911e-18
NZ_CP043006.1|WP_148389596.1|5912049_5913684_+|apolipoprotein-N-acyltransferase	gnl|CDD|143595	cd07571, ALP_N-acyl_transferase, Apolipoprotein N-acyl transferase (class 9 nitrilases). ALP N-acyl transferase (Lnt), is an essential membrane-bound enzyme in gram-negative bacteria, which catalyzes the N-acylation of apolipoproteins, the final step in lipoprotein maturation. This is a reverse amidase (i.e. condensation) reaction. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 9.	6.1262e-73
NZ_CP043006.1|WP_148389597.1|5913664_5914468_+|alpha/beta-fold-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	8.42404e-29
NZ_CP043006.1|WP_148389610.1|5936105_5936552_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.07461e-17
NZ_CP043006.1|WP_148389604.1|5924539_5931796_-|cell-surface-protein-SprA	gnl|CDD|275042	TIGR04189, gliding_motility-related_protein, cell surface protein SprA. SprA is a cell surface protein widely distributed in the Bacteroidetes lineage. In Flavobacterium johnsoniae, a species that shows gliding motility, mutation disrupts gliding.	0
NZ_CP043006.1|WP_148389595.1|5910449_5911925_+|IMP-dehydrogenase	gnl|CDD|376340	pfam00478, IMPDH, IMP dehydrogenase / GMP reductase domain. This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.	0
NZ_CP043006.1|WP_148389608.1|5934321_5934816_-|hypothetical-protein	gnl|CDD|225200	COG2318, DinB, Uncharacterized protein conserved in bacteria [Function unknown].	1.37919e-22
NZ_CP043006.1|WP_148389600.1|5919129_5919888_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187604	cd05346, SDR_c5, classical (c) SDR, subgroup 5. These proteins are members of the classical SDR family, with a canonical active site tetrad and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.08877e-127
NZ_CP043006.1|WP_148389599.1|5917186_5919118_+|T9SS-type-B-sorting-domain-containing-protein	gnl|CDD|372639	pfam13585, CHU_C, C-terminal domain of CHU protein family. The function of this C-terminal domain is not known; there are several conserved tryptophan and asparagine residues.	2.25104e-20
NZ_CP043006.1|WP_148389612.1|5936989_5937898_-|ACP-S-malonyltransferase	gnl|CDD|223408	COG0331, FabD, (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism].	8.21388e-120
NZ_CP043006.1|WP_148389602.1|5921554_5923828_-|TonB-dependent-receptor	gnl|CDD|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	1.43673e-59

Protein sequences

>NZ_CP043006.1|WP_148389602.1|5921554_5923828_-|TonB-dependent-receptor
MQRLLILILLTGIILPASAQQQLQGRVVDAQTHEALEGASITAIGCGCRSDEKGIFTLPALPDSIHISHLGYAGKCLPVIKDGNMIIYLEPQSARLNEVIVSAGRDRQFRTDAPVAISTISTRMIRETKATSLEQLLNKVSGVYMVDLGNEQHTMAIRQPIGYRSLFLYLEDGIPIRTTGDFNHNALIEINMAALKTIEVIRGPASSLYGSEAVGGAVNFITSSPAILPTAKVQAEMSDQGYKRTDFSVSGTTGKLGILLGGYYADRRNGYIDHSDFRKLALTLKAQYQFSDRSRWTNSISLTDYKTDQTGGVDSANFFSKNYKSLHTFSYRKVKALRVRSTLEHQWNGRNATNFTAFYRNNEIGQNPFYAIKTTSDPLKARGEINSDAFASYGLLVQHKKQFAWKKASLIAGMSVDYSPAGYFAEFIDVDRDAAGYFTGYAITDSVLTDYQVDLVNTAAYAQAEISPLESLKVIAALRYDRMDYNFDNHLPPSAFTGSPDERNYFHAWTPKLGLTYDFGRERGIYANYSVGFAPPNISELYRGVKVPSLRPATYNNYEIGGWFAFAGSKGYVDASLYRMDGKNEIVSVRLADGSSENRNAGKTRHSGVEWNLRYKPLPAILFRTGGTLAKHDFVEYEDKGNQYNDNRMNGAPAVITNTEITWKPAFLGGIRTGIEWQHVGKYFMDPANTEEYGGYELFNARIGYSRGGFECWLNCRNIADVMYATTVEKSAFGKSYRPGPNRTFNFGVAYTFTGKQ
>NZ_CP043006.1|WP_148389601.1|5920340_5921549_-|exo-alpha-sialidase
MKKWTVFAALAVSVTACRPAGFSGGPELVLSDTAYDASCAYMTRNAQGALVLSWVESAPGAETGTFHYAVSADNGQTFSAAKEVATATGIQPHAENLPKIIFRPDGEVIVMFGVQSNDPRNKYAGKVLYTSSPNGGASWQPAVPLVTDTAGYDQRYFDMALLPSGEAAVIWLDNRKHHQQEGSTLYMATTGERPGFRRERQIAQTVCQCCRTALYLDAQGSLHAAFRDIIHDTIRDMVHMVSADGGETFSPPRRISPDNWAINGCPHTGPAMVKNAEGLHFAWFTMGRGQGVFYCQSPDNGITYTKKESISALPTAKHPQLTALENGELVMVWDEAADTSSSRIGLLHKTGNGVTARSGFITPERTLAGYPVLKAAGERTVLVAYRKRKDDRGMICVQRVEL
>NZ_CP043006.1|WP_168208960.1|5920095_5920257_+|hypothetical-protein
MLTFVTMYILRLYYPRWKEFISFYLDGSRRNNYGRWAMRQSWKSEKSYSFGYN
>NZ_CP043006.1|WP_148389600.1|5919129_5919888_+|SDR-family-NAD(P)-dependent-oxidoreductase
MQGKIALITGATAGFGEACATAFAAAGYHLVITGRREERLRELQQQLEQAHAVKVKPLVFDVRNRKATEQALGSLEEHWRQVDVLINNAGLALDLSPVDEGDPDDWDTMLDTNVKGLLYVSRAVMPWMKARKQGQIVNIGSTAAKTVYAKGNVYCASKAAVDALTQGMRIDLLPWNIKVTAIHPGAAETEFSLVRFKGDEARAKDVYKGFTPLSAKDVADVALYCCSLPPHVCINDLVLTPTAQANAYYIQR
>NZ_CP043006.1|WP_148389599.1|5917186_5919118_+|T9SS-type-B-sorting-domain-containing-protein
MGKFLFLALIGSLLYSTVIAYHIIGGEIYYRSVGYNMANGSYRYIITLKLYRDGDFVCGTRQGCLDYFENPVPVNIFNAGGQRVMPPQLLSIQYTRSIRDTLKNPCLAPQTIYLEVAFYEGDTIELPPATGGYYISYQRCCRGESITNIYNSEREGSTFYTVIPGSESGRMDNNSAYFGIDEAPVICSGLPLRYNYSATDPDGDSLTYTLCSALASNTARSNESVSPPPYTTTVSYIPPYHGGDPLGGSPPLSIDNNGLITGTPNRSGKFVVSVCVSEYDRHTGRLLGTHHKDMLITVYSCATRIVASTPQLLNHCNDTLGLAVPISNNSVSGFTSTYQWTFSDGTDTLTDSRDIFFHHFPDTGVYTVKLVVNPGLPCTDSTTGRINNYPGLRADFSVSGLCREDPVYFDDHSTYRYGNIVSRRWDFGVQHTGSDTSMLLRPVFRYPNGGVYTIRLDLETDKGCEASVTRNLRLYEVNPFAGNDTILARGQTLRLQGQGGEVYNWWPPTGLTDPNVRDPILSWNDEISFVLRVSNQQGCFGYDTIHVKYYTGPQFYVPNAFSPNGDGQNDYFRFIPVGIQEYHFFRIFNRWGELVHSSLDFRRGWDGYHKGRPAPIDTYLWILEGVDLNGEKLFRKGTVTLVR
>NZ_CP043006.1|WP_148389598.1|5914473_5917059_+|PKD-domain-containing-protein
MRSLLIVTILGLVSLAARADHIIGGEMYYTYLGKNGVNNRYRISLKLFVRCDATNEQFDANVDISIFTGQGNFVTTLPPAGREKIERYTATDVDPCIVNPPFICYQIGYYHAEVELPPNAAGYVASFQRCCRRIGLANIFSDNTVGATYSVTIPGTDNGFDTNSGPRFSMEKGVIVCANNRFSYDYSAEDPDNDSLVYSFTTAYRGATQNNPKPVNSSPPPYSPVVYTNSFSASQPLGDKVTIDPQTGIISGIAPRSGLYIVTVTAKEYRNGVYIGENKKEFQFTVESCVKQVVASTPEEYKDCQSFTINFVNNSTPGKPYFWDFGDGDTLTTWSRDVLPHTYANPGTYTAKLAVDRESSCGDSMYTTVRVYPVLTPSFSVSGLCTSKPTEFTNTSVNTYGTIEYFKWDFGNTGVTNDTSNNSDPAYHYTQPGDYTVTLRVQTSMGCERTVSNTFTIYDKPPFTATNDTLLCYRNGIRFHAESPLPGSFSWAPLYNITGHLTANPYATPAVDTTYEVTFTDNSGCVNSKEIFVDVRDTIYVRTAADSTICTGDPITLTAETDGEYEFTWTDLNTNQVVATTRSTTIRPTASATYHVRVALGDCYSDDTVSYRTVDPPAAYAGLDTTICFGEKAFLHAAGGAFYTWQPASTVTSPRNATTIAWPEDTTVYIVTVTDTLGCPKAVPDSITVNVVPPVPAFAGNDTIIIKGQPFQLNASGGDVYHWSPPDGLNRTDIPNPVTTYNNDITYYLQVFSGEGCVGEDNIRIRFMNGPDIYVPNAFTPNGDGINDVFRPLPVGITKLELFRIYNRWGEEVFRTNEYLRGWDGKVRGRTADAGTYVWIVQGTNTAGEMMEKRGTVTLIR
>NZ_CP043006.1|WP_148389597.1|5913664_5914468_+|alpha/beta-fold-hydrolase
MWKKINNGNQEGAYWAEGQGKPVILIHGFGEDHSVWEHQIAFLRMYNRVLVPDLPGTRESPLAEGLSIESMAEFVYAILVEEGISQITMIGHSMGGYVALAFAEKYPHLLEGLGLFSSTAKPDSAEKKEARQKSIRMIGQYGSEAFLRQTLPTMFSESFRNKQPASVENFVTNALSIGKASLIAYYEAMMARPDRTAILKEIKVPVLFFIGKDDAAIPLNNILEQVTLPATASIHVFEQVGHMGLLEVYEESNLILHHFIAFCQRAV
>NZ_CP043006.1|WP_148389596.1|5912049_5913684_+|apolipoprotein-N-acyltransferase
MMNQTLRKRPPLLLSIIAGGIMWAAWPTSPLTFLVFIGLVPLLAVADRVSNRAAWFGLSFLTFWIWNTGATWWVGNTTVPASGIFANAFNALLMTIPWMGYKITLERHSRLTAYFSLVVYWLAFEYIHQEWELSWPWLTLGNAFAMRPEWVQWYEYTGTMGGSLWVLLVNISIYAAWRKRSKGTGSGSFLLWKEGWKPMLLLIIPIIISFIVVVNGKISKQAGIGVVVVQPNIDPYDEKFSMSSAQEQLAKLLELTRAKTGAGTRFVIWPETALFTQGAWEHELNNQPEVTAIRNFLRLYPDVKLITGASTYKQYPLPGEAPATARTRSDGGPPYDAFNSAIQIDTSSTIQIYHKAKLVPGVELTPYMRYLPFMKKLAMDFGGITGSYGLTPGVALFSNPPPHGNVFAAICYESVYSHFVAEKVRQGANLLVVSTNDGWWGNTQGHKQHMHYASLRAIETRRWVARSANTGISCFISPQGDVIAPQPYWQPAVIAHNVTKETRLTFYVKYSGYIAKAPLIFCILLLLYTIVLQVIRRRHVEKNQ
>NZ_CP043006.1|WP_148389595.1|5910449_5911925_+|IMP-dehydrogenase
MPAGKIKQKFVADGLTFDDVLLVPAYSDVLPREVNISSQLTKNIRINIPMVSAAMDTVTEARLAIALAREGGIGILHKNMSIDKQAELVRKVKRSESGMILDPLTLSADSTIGQALKMMRDNGIGGIPIVDGDKKLIGILTNRDLRFEKSNKRLISEVMTKDNLVTAPEGTDLKKAEKILQQHRIEKLPVVNKQGKLVGLITYRDILQLQSFPNSAKDSYGRLLVGAALGITHDLQERAAALLHVGVDVVTLDSAHGHSVHVLEALKKLKKAFPKLQVIGGNVATAEGALALAAAGADAVKVGVGPGSICTTRVVTGAGFPQLSAIMNAAQALKKSGIPVIADGGIRYTGDMVKAFVAGASTVMAGSIFAGVEESPGETIIYEGRKFKSYRGMGSIEAMSEGSKDRYFQDVEADIKKLVPEGIVGRVPYKGNLSEVVQQFVGGLRAGMGYSGSKDIKTLQEAQFVRITSATVRENHPHDVVITKEAPNYSR
>NZ_CP043006.1|WP_148389594.1|5909259_5910369_+|DNA-protecting-protein-DprA
MLQELHYRIALTLIPQVGDVVAKELLSHFGTATDIFQARRHQLERIPGVGTFRASAIRGFKDFAEVDQEIGFMNRHDIRPVFYTDDAYPERLRQCYDSPVLLYCKGSADLCAPRMLGIVGTRKPTAYGLAVCTELVASLAPHNVTIISGMAYGIDIAAHRAAVAHGLPTIGVLAHGLDRLYPATHAATARQMEHNGGLLTDFRSGTEPNRQNFPRRNRIVAGLCDATLVIESGQRGGSLITADIACSYHRDVLAVPGRTNDPASAGCLELIKQHKAALITSAEDIMQALNWRPAAPVKPLAPQTHLFYDLNEEQQLIVKLLQGNTPLHIDEIQARSGIPQNRIPGLLLELEMQALLRSMPGNTYQLINT
>NZ_CP043006.1|WP_148389603.1|5924066_5924489_-|hypothetical-protein
MILIIVASQPDRYICNILMRYIFVIITLTGLLLQTFGKGLILAEYMLNKEYISRVLCVNRAQPETGCNGQCHLMKQMEKETKNEQNGNAVKDKYEVVIAPIHAQFALQPYFTVTAINTAYSSDLPRNLNAAIFHPPRARA
>NZ_CP043006.1|WP_148389604.1|5924539_5931796_-|cell-surface-protein-SprA
MARKKYYGAIAVIGVVSFIIVDTAARSRNSSGYAYRSEYDIAVDRKIDSTAQDTTRRDTLKYPIHDRRGTSVTDPVRNAIDLKDPRNINKTVEYDPVTKQYIVTEKIGNQFYRQPTVLTFGEFYRLQAEQSERDYWQKRASTIGNLNQRTGAPQLYYGDKLFDRVFGGTKVDIKPQGSLGLTFGYQGQNVKNPILVERARKNGGFDFDIDINMNVTGRIGEKLKLITNYNTQSTFDFENQVKLEYTGYKDEIIQKIEAGNVSFPLSSSLISGVQSLFGVKTQLQFGRLTVTSVLSNQKSQKQNMTLRGGNSVQDFMIRADEYEDNRHFLLAQFFRDTFNYAMGNLPVIRSQVYINRIEVWVTNRTGATTNTRDIVGLMDLAEYDPFNPSINVLTSARLPDRNTNDLYGNIISDPGSRNSGTVVSRLLAMGLEPVQEFEKTFARKLDSTDYILNRQVGFLSLNQQLQPDEVLAVAYQYTYNGRVYQVGEFSQDVPPDQTNSANQKILFLKLLKATSARPALPIWDLMMKNIYSTNAFQINRQDFKLDVLYKDPGTDDRVPSEKRYLPDARGQFAGAPIITILNLDRLNNQNDPQPDGVFDYVEGYTINSQNGKVIFPVLEPFDDGLSRAFEGDPVLEKKYLYPMLYDSIKVIAQQFPNLNRFILRGSYKSSNSSEISLNAYNIPPGSVTVTAGGQMLRENVDFIIDYNLGRIKIINGGVLSSGVPINVQFENNALFGQQVRNYMGTRLDYYVSDKLNLGGTMVRMSERPYYQKVNYGDDPIRNTILGLDANYISDWRGLTRMLDKLPNFTANTPASINFTGEVAKLIPGHSKLVNEAGSKQGQVYIDDFEGARNGYDLKFPATAWALASTPKDASDASGTILFPEAEYNDSLAYGRNRALLAWYIIEPTLQIPRSPNLPRGITEASQFDPRSRLVYQKDVFPNRSTDFGQSQLSTLDLAFYPEERGPYNFEATPATLTPEGRLRNPRSRWGGIMRAIDNSDFETANIEFIEFWIQDPFINNPTSSGGKLFFNLGNVSEDVLKDGRKSFENGLPDPNTGLNKIDSSNWARVPKFQQQITQAFDNDPNIRRYQDVGYDGLQSVDERHFRRDYLDDIAAMFGTGSVIYETVQEDPSNDDYRWYRDATYDGGDGTDILGRYKRINNPEGNSPVSNDNSQFSQASTNYPESEDLNRDNTMNETEEYFQYRVELTPNMQVGSNYVVDKFTTVVQGPNNTTREETWYQFKVPVTQYDKKVGNIPDFKSIRFMRMFLTGFEDSVVLRFAKLDLVRNQWRRFLSELQPGDPVPIDESTVFNSSAVNIEENARRQPIPYVVPPGILRQNTLSTNNTNILLNEQSLAAQICNLKDGESRALYKNLNLDMRQYNRMQMFIHAEPAGSANALADDQLHAIIRVGSDFTENYYEYRIPLEITSWTGPHPEDSVWKEANNLDLELTKLTRAKQARNVAGASPLIPYVVQDGRNFITIMGNPSLGDVRGVMIGVFNPEDDGMPKCTEVWFNELRLTGLDEKGGYAALARVDLQLSDLGSITFSGNMHTAGFGAIDQRNNERFRDNYIQYDVATNLDLGKLLPKRAGISVPVYAGYSQTVSNPEYDPYDLDIKLKDKLELALDKQQRDSIKRNAQDFTSITSLNFTNVRKMTPGKTKNRLWDIENFDISYSYSQISRRNPVIENDVLTKHRAGLGYNFSGTPKYLEPFKSLIKSKSPWVGLIKEFNLNYVPTQLSFRADVTRQFGATRLRNVGGGPFQLQETYDKYFTFDRYYTLKWDFTRNLSLDFNASNLARIDEPMGRIDTDAKRDSVRSNLFKFGRTTNYYHTASVTYTLPTAKFPLLNWTNVALSYSTDYRWIGASRLAMYLGNAIENTQSKIVSAELKFSDLYNKSKWLRKMNAAPVRSTMPQMNNMNNNQPKPNQPNAAKKDEEETEGSGLVKGLMRVLMSLKRVQVNYTENAGTRLPGYIDSTKVLGMNWASMAPGIGFVLGQQPDRLWLDNFAKKGLLTRDTLFNIQFQQQFTQRLDAQAQLEPIRDLRIDLNLTKSFTKTYTELYKDTTGNGTFGHLSPYDAGGFEITFVAIKTMWGKINEQDGISQTFRDFESYRKIISRRLGAENPYSQDPSIPEFDPKDPEYRYGYGRYSQDVLIPAFLAAYTGKNPETISLLKQGAGGVRTNPFKNILPRPNWRISYNGLSRLAPFRNFLSVFTLTHAYIGNLSMNSYNTALMFYDPLLMGYPAFRDSVSGNYVPYFLLPNMTINEQFAPLLGVDMTFTNSLNARLEFKRSRTLSLSMIDYQLSEMRSSEIVVGAGYRVRGFPMPFKIGKEGGTRLENDLNFRLDISFRDDKTVNNRLDADIVIPTSGQKVIGIAPSIDYVINNRLNIKFFYDRRQTIPVISTAYPITNTRGGLTLRFMLAQ
>NZ_CP043006.1|WP_148389605.1|5931832_5932420_-|Holliday-junction-branch-migration-protein-RuvA
MIAYLIGKLAYKSPALVHLDVNGVGYEVQISLHTYSRIQSLESCKLLTFVHIKEDAHTMYGFFDEAERTIFLQLISVSGVGAGTARMMLSSLQPEDIQRAIVMDNEKMLEGVKGIGSKTAKRLILELKDKMRKHKEDVLHLSVTSHNTIQEDALNALVTLGIARNMAEQAVQRVLKAEPQLNELELLIKKSLKSL
>NZ_CP043006.1|WP_148389606.1|5932511_5933516_+|beta-ketoacyl-ACP-synthase-3
MSKITAAITAVGGYVPDYVLTNQELEKLVDTTDEWITTRTGIKERRILKGESMGTSELCVPVALEICRKRGISPEEIDLLIVATVTPDMVFPATANVVTDKIGAKNAFGFDIGAACSGFLYALDTGARFIESGRYKKVMVIGADKMSSIIDYTDRATCIIFGDGAGGILLEPDTEGFGVVDSILKSDGHGREFLNMKAGGSAKPASAETVANREHYVFQEGKTVFKYAVANMSEAAGDIMKRNHLTADDIAWLVPHQANLRIINATAGYMGLPEEKIMINIQRYGNTTAGTIPLCLWDWESKLKKGDNLILAAFGGGFTWGACYVKWAYDGDKI
>NZ_CP043006.1|WP_148389607.1|5933584_5934280_-|NUDIX-domain-containing-protein
MSIPSFYASSPRHLVAVDCIIFGFEGGKLKLLIMKRKVDPMEGAWSLVGGFVQEGESTDSAATRVLQQTTGIDDIYMDQLQCYGDVQRDTGARVISIAYYALINIQEHDRVMATEYGAHWLELHQIPELIFDHTQMLQDALARLRDKARFHPLGFELLPEKFSLPQLRNLYEEIYQRELDKRNFRKKILAMGILEKLDEKDKSTSKKGANLYRFDKQKYEALTRHGFVFEV
>NZ_CP043006.1|WP_148389608.1|5934321_5934816_-|hypothetical-protein
MKDLLLRYARYNIWANQRMLTLLNGLSEEQLDKDLGSSFSSLRKTIYHIWDAESIWFQRLQLASPVLVPTRTFTGDWEEFTHLFTRQSEQLKDFVATASDAKLAHTIEYNRLAKGIGKSAVVDALLTAFNHSTFHRGQLVTMLRQSGVSKIPPTDYIKYTGLKK
>NZ_CP043006.1|WP_148389609.1|5934878_5936099_+|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MKQAPLSGFSSVCVHAGHEQDPLYSHLTPIYASSTFVYDSAEQGMRRFSGQEEGYIYTRWDSPNFREAEEKIAALEGFGLTDESGRPLALKAILHASGMGALSTLFLANLKSGDKIISHYSLYGGTEELFSKILPPLGIEALIMDMQDLGKTAAAIQADPSIKMMYLETPANPTLKCVDLEALIALAHQHRLITAVDNTFATPYLQQPFAYGADYVFHSTTKFLNGHGTAIGGVLVGKDMEMMKGQVDKVHRLLGNNSNPFDAFLLTQGMKTLEVRMERHCHNAMEVAGFLDGHPAIARVNYLGLADHPDFAIASRQMKHPGAMLSFELKDGMKAGMRFIDRLQMCLRAVSLGTCDTLICHPASMTHYSIPQEIREKYGITDGLIRMSTGIESVTDILNDLEQALQ
>NZ_CP043006.1|WP_148389610.1|5936105_5936552_+|GNAT-family-N-acetyltransferase
MINIRKAEKKDCPRMMELVRELALYEKAPEQVTVTAEHFEETGFGPNPVWWAWVAEADGEIAGMALYYVRYSTWKGARMFLEDIIVTESWRGKGIGKLLFDRLIEEAREKKFSGMVWQVLDWNEPAINFYKKYNAKFDPEWLNVSIDL
>NZ_CP043006.1|WP_148389611.1|5936555_5936930_-|hypothetical-protein
MRLSLFLLAVLAAAPSCKEESLPDERWLESTQRQEVIVFKDVSPLDARGGEQSFYFQARKLPESSSITSPSGFYYYSLEGDSLLLNNTRKKVFFRMDESGRSFTIGRFFPDPGGLPELLIFEKQ
>NZ_CP043006.1|WP_148389612.1|5936989_5937898_-|ACP-S-malonyltransferase
MQHAYVFPGQGSQFPGMGKSLYDNNASAKALFEQANDILGFRISDIMFTGTEEDLRRTEVTQPAVFLHAVIAFLCIDDPRPAMTAGHSLGEFSALVANGVLAFEDALRLVAIRANAMQKACEATPSTMAAVLALDDAKVEEICASITDDIVVAANYNCPGQLVISGTVPAVERACELMKAAGAKRALILPVGGAFHSPLMAPAQAELQAAIEKTTFNTPACPVYQNVVAKAVTDPAEIKNNLISQLTGAVRWTQSVQAMIADGAQRFTEVGPGKVLQGLIQKIDKNAVTDGISTGLEEAMAK

Crispr_ID: NZ_CP043006_16

• CRISPR_ID: NZ_CP043006_16
• CRISPR_location: 6004155-6004252
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP043006_16

Consensus_repeat	Method
GCAACATCTCAATTAGGTATATAAACAAAAGAG	CRISPRCasFinder

spacers of NZ_CP043006_16

>16.1|6004188|32|NZ_CP043006|CRISPRCasFinder
TCTCGCCGGTTGCCTGTTGATGGAGTAAAGCT

CRISPR arrays and Neighbor proteins around NZ_CP043006_16

CRISPR arrays

The CRISPR arrays of NZ_CP043006_16

>merge|NZ_CP043006|16|6004155-6004252|CRISPRCasFinder
GCAACATCTCAATTAGGTATATAAACAAAAGAGTCTCGCCGGTTGCCTGTTGATGGAGTAAAGCTGCAACATCTCAATTAGGTATAAAAACAAAAGAG

>NZ_CP043006|16|13|6004155-6004252|CRISPRCasFinder
GCAACATCTCAATTAGGTATATAAACAAAAGAG	TCTCGCCGGTTGCCTGTTGATGGAGTAAAGCT
GCAACATCTCAATTAGGTATAAAAACAAAAGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043006.1|WP_168208964.1|6025958_6026429_-|CHRD-domain-containing-protein	unknown	unknown	gnl|CDD|377837
NZ_CP043006.1|WP_148389671.1|6024692_6025769_+|peptidase-M19	unknown	unknown	gnl|CDD|238626
NZ_CP043006.1|WP_148389660.1|5996634_5998359_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_CP043006.1|WP_148389661.1|5998871_6000593_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NZ_CP043006.1|WP_148389664.1|6002583_6003927_+|histidine--tRNA-ligase	unknown	unknown	gnl|CDD|234586
NZ_CP043006.1|WP_148389665.1|6015832_6016573_-|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl|CDD|234577
NZ_CP043006.1|WP_148389668.1|6018755_6021344_+|M1-family-metallopeptidase	unknown	unknown	gnl|CDD|341066
NZ_CP043006.1|WP_168208963.1|6000632_6001493_-|phosphate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|378974
NZ_CP043006.1|WP_148389658.1|5995359_5995923_-|NADH-quinone-oxidoreductase-subunit-B	unknown	unknown	gnl|CDD|184833
NZ_CP043006.1|WP_148389663.1|6002123_6002558_+|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl|CDD|319971
NZ_CP043006.1|WP_148390072.1|6021594_6022914_+|TRAP-transporter-large-permease-subunit	unknown	unknown	gnl|CDD|308194
NZ_CP043006.1|WP_148389669.1|6022931_6023396_+|RidA-family-protein	unknown	unknown	gnl|CDD|100006
NZ_CP043006.1|WP_148389673.1|6026481_6027423_-|hypothetical-protein	unknown	unknown	gnl|CDD|378075
NZ_CP043006.1|WP_148389667.1|6018139_6018643_-|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	unknown	unknown	gnl|CDD|133459
NZ_CP043006.1|WP_148389659.1|5995995_5996391_-|NAD(P)H-quinone-oxidoreductase-subunit-3	unknown	unknown	gnl|CDD|376344
NZ_CP043006.1|WP_148389670.1|6023408_6024674_+|D-TA-family-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|143495
NZ_CP043006.1|WP_148389666.1|6016667_6018119_-|DUF4476-domain-containing-protein	unknown	unknown	gnl|CDD|379689
NZ_CP043006.1|WP_148389656.1|5993007_5993502_-|NADH-quinone-oxidoreductase-subunit-NuoE	unknown	unknown	gnl|CDD|376507
NZ_CP043006.1|WP_148390071.1|5993573_5994791_-|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl|CDD|223722
NZ_CP043006.1|WP_148389657.1|5994818_5995340_-|NADH-quinone-oxidoreductase-subunit-C	unknown	unknown	gnl|CDD|376317

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP043006.1|WP_168208964.1|6025958_6026429_-|CHRD-domain-containing-protein	gnl|CDD|377837	pfam07452, CHRD, CHRD domain. CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..	1.85379e-26
NZ_CP043006.1|WP_148389671.1|6024692_6025769_+|peptidase-M19	gnl|CDD|238626	cd01301, rDP_like, renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Although the biological function of the enzyme is still unknown, it has been suggested to play a role in the renal glutathione metabolism.	9.19116e-54
NZ_CP043006.1|WP_148389660.1|5996634_5998359_-|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.30912e-07
NZ_CP043006.1|WP_148389661.1|5998871_6000593_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.09191e-07
NZ_CP043006.1|WP_148389664.1|6002583_6003927_+|histidine--tRNA-ligase	gnl|CDD|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	9.08219e-118
NZ_CP043006.1|WP_148389665.1|6015832_6016573_-|tRNA-pseudouridine(38-40)-synthase-TruA	gnl|CDD|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	7.05269e-93
NZ_CP043006.1|WP_148389668.1|6018755_6021344_+|M1-family-metallopeptidase	gnl|CDD|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.68547e-149
NZ_CP043006.1|WP_168208963.1|6000632_6001493_-|phosphate-ABC-transporter-substrate-binding-protein	gnl|CDD|378974	pfam12849, PBP_like_2, PBP superfamily domain. This domain belongs to the periplasmic binding protein superfamily.	3.26172e-42
NZ_CP043006.1|WP_148389658.1|5995359_5995923_-|NADH-quinone-oxidoreductase-subunit-B	gnl|CDD|184833	PRK14820, PRK14820, NADH-quinone oxidoreductase subunit B.	1.82452e-131
NZ_CP043006.1|WP_148389663.1|6002123_6002558_+|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl|CDD|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	8.23839e-69
NZ_CP043006.1|WP_148390072.1|6021594_6022914_+|TRAP-transporter-large-permease-subunit	gnl|CDD|308194	pfam02447, GntP_permease, GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter, and GntT, a high affinity transporter.	1.37578e-144
NZ_CP043006.1|WP_148389669.1|6022931_6023396_+|RidA-family-protein	gnl|CDD|100006	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.70425e-57
NZ_CP043006.1|WP_148389673.1|6026481_6027423_-|hypothetical-protein	gnl|CDD|378075	pfam08874, DUF1835, Domain of unknown function (DUF1835). This family of proteins are functionally uncharacterized.	0.000105108
NZ_CP043006.1|WP_148389667.1|6018139_6018643_-|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	gnl|CDD|133459	cd06850, biotinyl_domain, The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.	1.21573e-24
NZ_CP043006.1|WP_148389659.1|5995995_5996391_-|NAD(P)H-quinone-oxidoreductase-subunit-3	gnl|CDD|376344	pfam00507, Oxidored_q4, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.	2.22618e-33
NZ_CP043006.1|WP_148389670.1|6023408_6024674_+|D-TA-family-PLP-dependent-enzyme	gnl|CDD|143495	cd06821, PLPDE_III_D-TA, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase. D-threonine aldolase (D-TA, EC 4.3.1.18) reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. Its activity is present in several genera of bacteria but not in fungi. It requires PLP and a divalent cation such as Co2+, Ni2+, Mn2+, or Mg2+ as cofactors for catalytic activity and thermal stability. Members of this subfamily show similarity to bacterial alanine racemase (AR), a fold type III PLP-dependent enzyme which contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on its similarity to AR, it is possible that low specificity D-TAs also form dimers in solution. Experimental data show that the monomeric form of low specificity D-TAs exhibit full catalytic activity.	6.63935e-152
NZ_CP043006.1|WP_148389666.1|6016667_6018119_-|DUF4476-domain-containing-protein	gnl|CDD|379689	pfam14771, DUF4476, Domain of unknown function (DUF4476).	1.52612e-05
NZ_CP043006.1|WP_148389656.1|5993007_5993502_-|NADH-quinone-oxidoreductase-subunit-NuoE	gnl|CDD|376507	pfam01257, 2Fe-2S_thioredx, Thioredoxin-like [2Fe-2S] ferredoxin.	1.03116e-79
NZ_CP043006.1|WP_148390071.1|5993573_5994791_-|NADH-quinone-oxidoreductase-subunit-D	gnl|CDD|223722	COG0649, NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion].	7.86092e-162
NZ_CP043006.1|WP_148389657.1|5994818_5995340_-|NADH-quinone-oxidoreductase-subunit-C	gnl|CDD|376317	pfam00329, Complex1_30kDa, Respiratory-chain NADH dehydrogenase, 30 Kd subunit.	1.7834e-47

Protein sequences

>NZ_CP043006.1|WP_148389664.1|6002583_6003927_+|histidine--tRNA-ligase
MAKLSIPQGTRDFGPDVVRKRNYIISTIRKTFELYGFQPLETPAMENTSTLLGKYGEEGDRLIFKILNNGDILGQAQLAKDSRELGLLLCEKSLKYDLTIPFARYVAMNHGKLNLPFRRYQIQPVWRGDRPQAGRYREFYQCDADVIGSNSLINEVELLKIYDTVLTDLQLTGYELRVNNRKILAGLAELVGRPDLMTDITIAIDKLDKIGENGVRQELVERGLTDTETDKAMAFISLTGTNEQKLQRLSELLASSDTGLKGVEELRFVLRNQLASFRVEPQLDLTLARGLNYYTGMIVEVKAPAGVNIGSIGGGGRYDDLTGLFGVPGISGVGISFGLDRIYDVLEKLGLFPASAEESTRVIFFHPGAERLAEVFRYATQVRERGIAVEMYPEDIKQDKQYKYAEKRGIPFIAYVEDNAPDTIFIKDIPGKQRYTVKAGELGDFGF
>NZ_CP043006.1|WP_148389663.1|6002123_6002558_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MKILMVCLGNICRSPLAEGILRHLAVQRQLNWEIDSAGTGNWHVGDPPDPRSVKVAKKHGIDISGLRGRQFQAGDFERFDSIYVMDLDNYRDVLRKARSDADRSKVQLLLEHQQPVPDPWYDDALFEPVYHLIYDACERIVNTP
>NZ_CP043006.1|WP_168208963.1|6000632_6001493_-|phosphate-ABC-transporter-substrate-binding-protein
MAACNTGSSRKGAEQDTPTKGTIRISVDETYKPLIESEIRVFESLYPKAKIIAEYKPEADCFKDLFNDSSRLIIVTRDLKEEEKEYFKKEKIRPQSLQLATDAVALIVNNANPDSILTMDQVRKIMSGEAEKPWQIVFDNQHSSTVRFILDSINKGKPLPANTMAAQTNPEVIGYVEKSKNAIGVIGVNWISDTNDSTSIEFTNRVTTVKVRADNNTDFVQPYQFYIGMKSYPLTRGMFFVLKEPYHGLGAGFATFLGGQEGQLLIGRYKLYPARLNIVFREATLK
>NZ_CP043006.1|WP_148389661.1|5998871_6000593_-|tetratricopeptide-repeat-protein
MNTRKSLFVAMLCVANGAMAQSVEDGLKDLYYGKFQTAKQNLEKAITAKPTDDRAYYYLGIAELGLENKDGAAAAFTKGLAAVPNSPLLTAGMGRIDLLNGKPAEAKQKFDAATTASEGRDGDVARAIADANSEIQGGDRGYALTTMETLLNNEGRKRKQQYTATAADFIELGDAYRFLGGENGGKAVTAYERALELDPNNAEAVMKQGLVNYNARLLQQAVTDWTKATNMDPNYAPAYFELYQFYITPKKNQLSWENAATYLQKYIDAIGDGGDKIENAYNLAAIAFYQKRYDEAVQKGKSALSMLNADQKGRFIRLIGDAYLQKGDSLNAQKVMEDYIKVAGDDKLVANDFKLLSAIYGKLTPSDSATEAQYDSLAGIYLERYADLDTAKDHETYRGIAEAFKEMRNYSKTAKWYGKTLELEENPRAIEDHFFKGVYEYYAAEYSKADSTWAAFSAKYPEQANGYYWRGMSNFAMDQQAKEGKAKEPFEKYLTMIKPEDEAKSKRFLTNVYTYMMLYYYNLDDKTNMQPFMDKLTAIDPANETARQVKEYLESVEKAAASKTAKATQGAGK
>NZ_CP043006.1|WP_148389660.1|5996634_5998359_-|tetratricopeptide-repeat-protein
MNKRISTVFALLLLAGGVMAQSIDDGLKKLYYGKYAGAKQDFESVIASKPTDDRAHYYLGIAELGMENQEAAAAAFTKGLTAVPNSPLLTAGMGRIDLLNGDTAAARQKFDAALAGVKGKNGEVSRAVADANSEIKGGNKAFALATMETLMNNEGAKRRDIYDATAADYIELGDAYRALGGENGGKAITAYERALELDANNAEAVMKQGHVNYNAKLLEQAVGDYARAASLDPNYAPVFYELYQFYYTPRPRQFSLAKAKENLQKYLSLSDPSDKVKNEYYLASIMFFDRDYDSAIAKAQSLIPQANDSYKMKLHRLIADAHLQKGDSLTARKVYDDYVQKVGEAKLEPLDYKLGSEIYGRIKYQDSASQVEIDNKALEYLEKYATADTVKDLDRYESVAKAYQEARVFDRAADWYKKFAELKVEMKEKPSALDYYNIGLNYYRASAGEGMTDTVMLNKADSAFGQISTNFPDLTTGHYWQGMTAAGKDVEAKTGVALPYFEKYIAMAESDVERNKIGLIKAYTYLMVYYYNKEDNANLQKYMSKLEPLDPNSEPVRAIKENMSARSAQQNSTK
>NZ_CP043006.1|WP_148389659.1|5995995_5996391_-|NAD(P)H-quinone-oxidoreductase-subunit-3
MFFASEFLTASNTPFSYFPIVLQLIVALGFVGVTMIATHFLGPKRKTSDKLVNFESGIEQMGNARQPVAVKYFLTAILFVLFDVEVIFFYPYAVNFKELGWEGFLAMLAFVAFFMGGFYYIIKKGALRWED
>NZ_CP043006.1|WP_148389658.1|5995359_5995923_-|NADH-quinone-oxidoreductase-subunit-B
MSRPVQFNNKVKLVEMPEGYSGEGFFATSFDKVIGLARKNSIWPLPFATSCCGIEFMATMAAHYDLARFGSERLGFTPRQCDLLMVMGTIAKKMAPVLRQVYLQMAEPRWVIAVGACASSGGIFDTYSVLQGIDQVIPVDVYVPGCPPRPEAILDGVMRIQDIVGEESLRRRHSERYKDLMNSYGIQ
>NZ_CP043006.1|WP_148389657.1|5994818_5995340_-|NADH-quinone-oxidoreductase-subunit-C
MSLTNEHIKNRLAEKFGDALTNFEESFGMMSFHAPKDLNLKVMQFLFDEEDLRFRFLTDLTAVHYPDRTGEELAVVYHLHNFADNVRLRFKVFTDINSPQVFTATQIFATANWMERETYDFYGVDFVGHPNLVRILNVDEMDYFPMRKEFPLEDQSRVDKDDEMFGRGGITGI
>NZ_CP043006.1|WP_148390071.1|5993573_5994791_-|NADH-quinone-oxidoreductase-subunit-D
MSEHKHITLPDGSIEKQTSTLNLGPTHPATHGVFQNVMEMDGERIVSTVPTVGYIHRAFEKIAERRPYYQITPLTDRLNYCSAPINNMGWHLTVEKLLGIQTPKRVDYLRVVIMELARITDHLICNSVIGVDSGAFTGFLYVMQYRELVYEIYEEICGSRLTTNIGRVGGFERNFTPEAFRKIEKFLAEYPAVLKEFENLFTRNRIFMERTQGVGAITAERAMNYGFTGPNLRATGVDYDVRVASPYCSYEDFEFTIPVGTTGDTYDRFLVRNAEMWQSLSIIRQAMEKLKTLPEDVFHADVPAYYLPDKDDVYTKMEALIYHFKIVMGETDILPGELYNPVEGANGELGFYLISDGGRSPYRLHFRRPCFIYYQAYPELVQGAMLSDAIICMSSLNLIAGELDA
>NZ_CP043006.1|WP_148389656.1|5993007_5993502_-|NADH-quinone-oxidoreductase-subunit-NuoE
MAVQFSEEKLNKVKEIIARYPEGKQKSALIPVLHLAQESFGGWLSAETMDYVASLLQIAPIEVYEVATFYSMYNLKPVGKYLFEVCHTGPCMLSGSDNIIEYIKERLGINVGETTADGLFSLKTVECLGACGYAPMMQLGKFYKEHLTKARVDEIIAECRAKSN
>NZ_CP043006.1|WP_148389665.1|6015832_6016573_-|tRNA-pseudouridine(38-40)-synthase-TruA
MARYFIEVAYMGGRYSGFQVQENAVTVQSEIDRAAGLLMRGKVVTTGSSRTDAGVHARQNFLHFDTDQELHPQFVYKMNAILPHDIVVKGVYPVDESVHSRFSAIGRAYEYTLYTSKDPFLTDRGYFYPYRMDMAQLQAAAEIIREYVDFSTFSKRNTQVKTFNCRITASFWTEYDNRIVYSVSANRFLRGMVRGLVGTMLRVGRGRLTLEEFREVIGSRDCTRADFAVPPQGLCLMSVLYPEGLF
>NZ_CP043006.1|WP_148389666.1|6016667_6018119_-|DUF4476-domain-containing-protein
MYRSKLKLLYLFCCLLVAGGLSAQDQAHFVYIQHEQQQPFYVKLNGKVVSSSSRGYVILSKLPQGKVPVTVGFLKNGMPEQEYTLRITGQRDYGYLLKNTGDKEFALYDLQTFATLNAAGGGAGVEAPQEEVVVTRLSDDTASEETKAMMDNVQADVQAALTRASGDTAPPPSGKKSSFAEALDKVVKDDRPDDMPLEFAQPKAAEPVPVVPAGGELTETVAVEQPAKKRNRRKERKERETLTEAEQALLSSVLEDEKQAAAAEALKEAPKEVALTDQEEAEPTPVKQKKVKKKKDQPEPEFIDFGEGGTAPAAAAKPPVMEEAVAVVDAAPEISAKEARDARRQKRKEEREAAERAAFVKDSIANSEYGVIPEAPEKKRVEMVNSDCPRVLETDAFRKLLRTMNSRKTDEDMVDAFRKGTRSVCVSTEQIRALAQLIATEENRYQLLDAAYPRTYDSQHFSSLVDLLKDGYYQRRFKAMITK
>NZ_CP043006.1|WP_148389667.1|6018139_6018643_-|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit
MMIKAIVNGAQPFEITSPADGISCNGRKTEWSAEALPSGGYSILMDGKSYVAEVVRTDRDTKTVTLQLGQRLFEVKLEEPMDRLLAAMGISEASSRKLNDIKAPMPGMVLKVLVSPGQAISKGDPVLILEAMKMENVFKAPSDAVVKEVKVTERKAVEKGEVLIVLE
>NZ_CP043006.1|WP_148389668.1|6018755_6021344_+|M1-family-metallopeptidase
MHHHFQTSIRTLLAGLLFTGLCTGVLAQTGGARQEDPALSIYRATPTKINNLVHTKLDVKFDYAKRYLHGKAWIVLKPHFYPTDSLTLDAKGMDLKQVSLVQTGNTGKTAPTDLLLRTARQTPLKYAYDGQQIRIQLNKTYKNTESYTVFVEYTAKPDELEVKGSNAITDAKGLYFINPDGKDPKKPIQIWTQGETEASSVWFPTIDKTNQKTTSEISMTVDKKYVTLSNGRLAGQKNNADGTRTDTWRMDLPHAPYLFMMAVGDFAVVKDKWRDKQVNYYVEKEYAPHAKAIFGNTPEMMTFFSKLLDYDYPWVKYSQIVVRDYVSGAMENTTATIHGDFLQKTDRELLDDDDRLGESVIAHELFHHWFGDLATCESWSNLTMNESFADYSEYLWFEHKFGKDAADEHAYSALNSYLEMAEYQGDRHLVRFHYHDKENMFDQVSYQKGGRILHMLRNYVGDDAFFKALNLYLKEHAFKATEAHHLRLAMEEVTGQDMNWFFNQWYFGQGYPTLDINYDYSQAGTAKVILTQKGEKVFDLPITVDVYTGGKKERHNIRLTEKADTFSFAVNGKPDFINVDADKVLILRKTDRRDLNTYVFQYKNAPQYLDRREAIEACLKQQTSNAGARATAIAALKDPYEGLRALAVDGLKLDNNDVKTAALPILLDLAKNDKHSQVRAAALRQLGRLKDTAYTPLFEAALKDRSYMVEGIALNALAELDMTKAYSLAKAMEKDAKGLLSSGIANVYARNGNIADVPFFAKQLEETSGQEKIGAAIMYLNILANVDDTELVTKGIDQVVDVVTGFNNTWVNNYIINLLAPMAEKKHSKAATADAALKAELTKQAEYAQQAAAKIKASSSEE
>NZ_CP043006.1|WP_148390072.1|6021594_6022914_+|TRAP-transporter-large-permease-subunit
MPLIYAVAAILLLIVLILWVKLDTFISFLIVSIILALACNMSGPEIGSAISNGIGSTLGSLVTILGFGAMLGKLVADSGAAQQITSSMIRIFGIRHIQWGMALAGLLVGIPMFYTAGFVIVVPLIFATGMSTRLPLLYLGIPMISALSTAHGFLPPHPSPTAISQQLGADIGKTLVYGLLISIPTIALAGPVFGRSLRKMNITPEQGLLNITFREEKDMPGLGISLATALLPLILLTLTTALAPLMVEGTALTRALRFIGDPNIAMLLSVLAAIYFLGVRRGQPMKTVMKSIEQALKDVAPVMLIIAGAGVFMQVIKDGGINTYIGEALKDLPVSPLVLGWTIAAVIRVCVGSATVAGLTTVGILLPLIQQEVVHPELMVLSIGAGSLMFSHVNDGGFWLFKEYFNLSLKQTFATWSVMETIVSVCGLLGVLALELFIG
>NZ_CP043006.1|WP_148389669.1|6022931_6023396_+|RidA-family-protein
MTAAENFAALGLNLPPCPAPKGVYKPLLIVGNLVYVSGHGPVLDDGSLLFGKAGLEVNADGAKLAAQQVGLTILSTLVSQLGSQDRIKRVIKVLGMVNATPDFGKHPYVINGCSELFAKVWGPDNGVGVRSAVGMGSLPDNITVEIEAVFELAD
>NZ_CP043006.1|WP_148389670.1|6023408_6024674_+|D-TA-family-PLP-dependent-enzyme
MQADWYHLKDPDTVASPALLVYPQQVEMNIDRMIAIAGGPGHLMPHVKTHKMKPIVQMQLDKGIHRFKCATFAEALMLAEAGAQDILMAYQLTTPVAEQFALLAKQYPKSRFSSLVDNLDSAMLLNKIFSPPGDQFAAGHLLNDIDHPPRDHFGTVPAPESAAVANVYIDIDNGMHRTGLAPEKVFALYEQLQSLPHVQCLGLHAYDGHIRDTDLAVRTEKCEAAFAVVAALAARMPGAEIIAGGSPTFPVHASRLKAWEKIAAADTGNTETAEAKDAAASGHKGVRLTCSPGTCVLWDEGYGSTLPDQPFITAALLLTRVISKPQEGHMTLDLGHKAVSAENPITKRAFFHELGEYEVISQSEEHLVVKTPLAGRFKVGDVLYGTPWHVCPTVALYNEAQIIENGILTDTWPIARGRKLL
>NZ_CP043006.1|WP_148389671.1|6024692_6025769_+|peptidase-M19
MQPLIFDAHLDLGMNALEWNRDLTKSVNAIREREKHMNDKPDRGHGTVSLPEMRKGRVGLCVATQIARYVGLDNPLPGWHSQEQAWAQTQGQLAWYQAMEAKGEMKQITNAAELSTHIKLWETATDTSSLPVGFILSLEGADSFFELACVEKAYISGLRAVGPAHYGPGVYAYGTDADGGLGTKGRALLKELERFGIILDATHLCDKSFYEAMDHYTGPVWASHHNSRTIVPHNRQFSDEQFSLLIQRGAVIGTAFDAWMLIPGWERGKSTPEQTGVSLQHIADQIDHICQLAGNSRHAAIGSDLDGAFGTEQTPKDLNTIADLQKLPEILQNRGFTAEDIDNITSRNWIRFLLDTWS
>NZ_CP043006.1|WP_168208964.1|6025958_6026429_-|CHRD-domain-containing-protein
MKNLHSLVFITMGLFCLLAVACRKDKDDDNLYRATNAPITGAQESPAVTTTGSGSFNATYNPASKEMNITISWQGLTGNATLMHIHGPADRGTNAGVLQNFATLFAAAPSGSFSTSFVLNGTTQTEADLLGGKWYVNIHTAAHPGGEIRGQIELTN
>NZ_CP043006.1|WP_148389673.1|6026481_6027423_-|hypothetical-protein
MILHILNGDATREIFEQSGLEGDMIVWREMLCEGKAPATEELPRFFEERAAHLQQVYGLDRKTYLDTIGEDYKKLGKASSYDEVVLWFEFDLFCQVNMLFVLYYLKKLNPALPPVSIVQLHKHPEVPNFRGLGMLRQEHLPPLFEQRVYLQEEDWQLAADAWEAYRSEDPLALEQLSYHRTERLPYLGIALQAHLKRLPGKENGLNAVEHFFLDRLSLGKLRERDLYYQFWDELKIYGFGDFQLDIYTQRLQRAGVVQRNDEMLCLTGLGKEILNAEENYLSFACQDNIWIGGIPLEHTPWRWDDEEGKVVHS

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP043006_3	3.5|1667064|24|NZ_CP043006|CRT	1667064-1667087	24	NZ_CP024314	Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence	511255-511278	3	0.875
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	581154-581183	4	0.867
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	MN694471	Marine virus AFVG_250M232, complete genome	10014-10043	6	0.8
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP052758	Cellulosimicrobium sp. BI34T plasmid pCPRO01, complete sequence	37822-37851	6	0.8
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NC_019789	Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence	468936-468965	6	0.8
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP030127	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence	142655-142684	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	656455-656484	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP012886	Mycobacterium chimaera strain AH16 plasmid unnamed1, complete sequence	150698-150727	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP032686	Rhizobium sp. CCGE531 plasmid pRCCGE531c, complete sequence	115818-115847	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP032688	Rhizobium sp. CCGE531 plasmid pRCCGE531a, complete sequence	189985-190014	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP032691	Rhizobium sp. CCGE532 plasmid pRCCGE532c, complete sequence	110778-110807	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP032693	Rhizobium sp. CCGE532 plasmid pRCCGE532a, complete sequence	189974-190003	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP006987	Rhizobium sp. IE4771 plasmid pRetIE4771a, complete sequence	139338-139367	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP013523	Rhizobium phaseoli strain R744 plasmid pRphaR744a, complete sequence	181744-181773	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NC_020060	Rhizobium tropici CIAT 899 plasmid pRtrCIAT899a, complete sequence	124896-124925	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP017103	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872a, complete sequence	81765-81794	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	CP006878	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602a, complete sequence	112676-112705	7	0.767
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP034999	Rhizobium acidisoli strain FH23 plasmid pRapFH23a, complete sequence	414638-414667	7	0.767
NZ_CP043006_3	3.3|1666962|36|NZ_CP043006|CRT	1666962-1666997	36	KT253150	Rhodobacter phage RcSaxon, complete genome	2967-3002	7	0.806
NZ_CP043006_3	3.3|1666962|36|NZ_CP043006|CRT	1666962-1666997	36	NC_028954	Rhodobacter phage RcRhea, complete genome	3047-3082	7	0.806
NZ_CP043006_3	3.3|1666962|36|NZ_CP043006|CRT	1666962-1666997	36	NC_042049	Rhodobacter phage RcCronus, complete genome	2967-3002	7	0.806
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NC_024794	Escherichia phage vB_EcoM_PhAPEC2, complete genome	158455-158484	7	0.767
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP029358	Azospirillum sp. CFH 70021 plasmid unnamed3	145052-145081	7	0.767
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP031080	Paracoccus yeei strain CCUG 32053 plasmid pYEE2, complete sequence	252414-252443	7	0.767
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP024424	Paracoccus yeei strain TT13 plasmid pTT13-2, complete sequence	130986-131015	7	0.767
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP020440	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence	16233-16262	7	0.767
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	JN698994	Mycobacterium phage DS6A, complete genome	21412-21444	7	0.788
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	NZ_CP015738	Shinella sp. HZN7 plasmid pShin-02, complete sequence	362228-362260	7	0.788
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	NC_017958	Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence	1115065-1115097	7	0.788
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	730343-730372	8	0.733
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	628543-628572	8	0.733
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_CP015006	Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence	506076-506105	8	0.733
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	473365-473394	8	0.733
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NZ_AP022611	Mycolicibacterium madagascariense strain JCM 13574 plasmid pJCM13574	63385-63414	8	0.733
NZ_CP043006_3	3.2|1666914|30|NZ_CP043006|CRT	1666914-1666943	30	NC_008382	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL7, complete sequence	72936-72965	8	0.733
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP029452	Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence	1314928-1314957	8	0.733
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NZ_CP023071	Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence	1291619-1291648	8	0.733
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	MT310875	Microbacterium phage Ashton, complete genome	31481-31510	8	0.733
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	NZ_CP011276	Planctomyces sp. SH-PL62 plasmid pPL62-3, complete sequence	49137-49169	8	0.758
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	AP014018	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S35-C77, *** SEQUENCING IN PROGRESS ***	19415-19447	8	0.758
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	AP014019	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S39-C83, *** SEQUENCING IN PROGRESS ***	12611-12643	8	0.758
NZ_CP043006_3	3.7|1667157|36|NZ_CP043006|CRT	1667157-1667192	36	KU686197	Synechococcus phage S-CAM3 isolate 0808SB25, complete genome	35198-35233	8	0.778
NZ_CP043006_3	3.7|1667157|36|NZ_CP043006|CRT	1667157-1667192	36	KU686199	Synechococcus phage S-CAM3 isolate 1010CC42, complete genome	35186-35221	8	0.778
NZ_CP043006_3	3.7|1667157|36|NZ_CP043006|CRT	1667157-1667192	36	KU686198	Synechococcus phage S-CAM3 isolate 0910TB04, complete genome	35205-35240	8	0.778
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	NC_023285	Streptomyces sp. F8 plasmid pFRL5, complete sequence	300748-300777	9	0.7
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	KM434186	Pseudomonas phage vB_PaeM_PS24, complete genome	82416-82445	9	0.7
NZ_CP043006_3	3.4|1667016|30|NZ_CP043006|CRT	1667016-1667045	30	MN694689	Marine virus AFVG_250M951, complete genome	12580-12609	9	0.7
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	AY848687	Enterobacteria phage PR5, complete genome	11295-11327	9	0.727
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	NC_011273	Mycobacterium phage Myrna, complete genome	63850-63882	9	0.727
NZ_CP043006_3	3.7|1667157|36|NZ_CP043006|CRT	1667157-1667192	36	MN693933	Marine virus AFVG_250M271, complete genome	18005-18040	9	0.75
NZ_CP043006_3	3.7|1667157|36|NZ_CP043006|CRT	1667157-1667192	36	MN694544	Marine virus AFVG_250M272, complete genome	17997-18032	9	0.75
NZ_CP043006_4	4.1|2118669|34|NZ_CP043006|CRISPRCasFinder	2118669-2118702	34	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	13800-13833	9	0.735
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	AP013470	Uncultured Mediterranean phage uvMED DNA, complete genome, group G18, isolate: uvMED-CGR-C56A-MedDCM-OCT-S32-C59	5327-5359	11	0.667
NZ_CP043006_3	3.6|1667106|33|NZ_CP043006|CRT	1667106-1667138	33	AP013751	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C56A-MedDCM-OCT-S46-C59, *** SEQUENCING IN PROGRESS ***	34100-34132	11	0.667

1. spacer 3.5|1667064|24|NZ_CP043006|CRT matches to NZ_CP024314 (Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence) position: , mismatch: 3, identity: 0.875

ggcggcggcggatacaaccgtggc	CRISPR spacer
ggcggcggcggatacaactatgga	Protospacer
******************..*** 

2. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 4, identity: 0.867

cgtggcggtggtggcggttacga-tcgcggt	CRISPR spacer
ggtggcggtggtggcggctacgagtcgcgt-	Protospacer
 ****************.***** *****  

3. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to MN694471 (Marine virus AFVG_250M232, complete genome) position: , mismatch: 6, identity: 0.8

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
cttggcggtggtggcgggtacgattttgat	Protospacer
* *************** ******. .*.*

4. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP052758 (Cellulosimicrobium sp. BI34T plasmid pCPRO01, complete sequence) position: , mismatch: 6, identity: 0.8

cgtggc-ggtggtggcggttacgatcgcggt	CRISPR spacer
-gcggtgggtggcggcggtgacgatcgcggc	Protospacer
 *.**. *****.****** **********.

5. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NC_019789 (Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence) position: , mismatch: 6, identity: 0.8

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
ggtggcggtggtggcggtaacggcgacggt	Protospacer
 ***************** ***.. .****

6. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP030127 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
ggcggtttcgaccgtggcggcggcattgcc	Protospacer
******* ***************.. *  .

7. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
ccaggtatcgaccgtggcggcggtggtcag	Protospacer
   ***  *******************.* 

8. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP012886 (Mycobacterium chimaera strain AH16 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
gacggttacgaccgccgcggcggtggcgtg	Protospacer
*.************. **********.   

9. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP032686 (Rhizobium sp. CCGE531 plasmid pRCCGE531c, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
cgcggttacgaccgtgacgccggtcggaaa	Protospacer
 ***************.** **** *  * 

10. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP032688 (Rhizobium sp. CCGE531 plasmid pRCCGE531a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
cctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

11. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP032691 (Rhizobium sp. CCGE532 plasmid pRCCGE532c, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
cgcggttacgaccgtgacgccggtcggaaa	Protospacer
 ***************.** **** *  * 

12. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP032693 (Rhizobium sp. CCGE532 plasmid pRCCGE532a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
cctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

13. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP006987 (Rhizobium sp. IE4771 plasmid pRetIE4771a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
tctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

14. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP013523 (Rhizobium phaseoli strain R744 plasmid pRphaR744a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
tctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

15. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NC_020060 (Rhizobium tropici CIAT 899 plasmid pRtrCIAT899a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
tctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

16. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP017103 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
tctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

17. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to CP006878 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
tctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

18. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP034999 (Rhizobium acidisoli strain FH23 plasmid pRapFH23a, complete sequence) position: , mismatch: 7, identity: 0.767

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
cctgttcaccaccgtggcggcggtcgttat	Protospacer
  .* *.** ************** *****

19. spacer 3.3|1666962|36|NZ_CP043006|CRT matches to KT253150 (Rhodobacter phage RcSaxon, complete genome) position: , mismatch: 7, identity: 0.806

tacaaccgcggcggcggcggatatgatcgcggcggc	CRISPR spacer
gacgaatgcggcggcggcggacaggatcgcggcgac	Protospacer
 **.* .**************.* **********.*

20. spacer 3.3|1666962|36|NZ_CP043006|CRT matches to NC_028954 (Rhodobacter phage RcRhea, complete genome) position: , mismatch: 7, identity: 0.806

tacaaccgcggcggcggcggatatgatcgcggcggc	CRISPR spacer
gacgaatgcggcggcggcggacaggatcgcggcgac	Protospacer
 **.* .**************.* **********.*

21. spacer 3.3|1666962|36|NZ_CP043006|CRT matches to NC_042049 (Rhodobacter phage RcCronus, complete genome) position: , mismatch: 7, identity: 0.806

tacaaccgcggcggcggcggatatgatcgcggcggc	CRISPR spacer
gacgaatgcggcggcggcggacaggatcgcggcgac	Protospacer
 **.* .**************.* **********.*

22. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NC_024794 (Escherichia phage vB_EcoM_PhAPEC2, complete genome) position: , mismatch: 7, identity: 0.767

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
ggtggcggtggtggcgcttacggtcgaaac	Protospacer
 *************** *****.*** ...

23. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP029358 (Azospirillum sp. CFH 70021 plasmid unnamed3) position: , mismatch: 7, identity: 0.767

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
cttcctggtggtggcggtgacgatcgcgcg	Protospacer
* *  .************ *********  

24. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP031080 (Paracoccus yeei strain CCUG 32053 plasmid pYEE2, complete sequence) position: , mismatch: 7, identity: 0.767

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
cctggcggtggtggcggtgccgatccgcat	Protospacer
* ****************  *****   .*

25. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP024424 (Paracoccus yeei strain TT13 plasmid pTT13-2, complete sequence) position: , mismatch: 7, identity: 0.767

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
cctggcggtggtggcggtgccgatccgcat	Protospacer
* ****************  *****   .*

26. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP020440 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
cctggcggtggtggcggtgccgatccgcat	Protospacer
* ****************  *****   .*

27. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to JN698994 (Mycobacterium phage DS6A, complete genome) position: , mismatch: 7, identity: 0.788

cgcggcggtggcggcggcggttatgaccgtggc-	CRISPR spacer
cgaggcggtggcggcggcggttgtgg-cgcaaca	Protospacer
** *******************.**. **...* 

28. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to NZ_CP015738 (Shinella sp. HZN7 plasmid pShin-02, complete sequence) position: , mismatch: 7, identity: 0.788

cgcggcggtggcggcggcggttatga--ccgtggc	CRISPR spacer
ccgggcggtgccggcggcggctatgacgccatg--	Protospacer
*  ******* *********.*****  **.**  

29. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to NC_017958 (Tistrella mobilis KA081020-065 plasmid pTM3, complete sequence) position: , mismatch: 7, identity: 0.788

cgcggcggtggcggcggcggttatgaccgtggc	CRISPR spacer
cgcggcggtggcggcggcgctgatcgcgctgcc	Protospacer
******************* * ** .*  ** *

30. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 8, identity: 0.733

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
catagcgtcgaccgtggcggcggcggttat	Protospacer
 ...*.  ***************.******

31. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
ggcggttacggcggtggcggcggcagcggc	Protospacer
**********.* **********..*. ..

32. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_CP015006 (Aminobacter aminovorans strain KCTC 2477 plasmid pAA01, complete sequence) position: , mismatch: 8, identity: 0.733

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
ggcggttccgaccgtggcggcatccggtga	Protospacer
******* *************. . * *. 

33. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 8, identity: 0.733

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
ggcggtgccgaccgtggcggcggcgcccgc	Protospacer
******  ***************.* ....

34. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NZ_AP022611 (Mycolicibacterium madagascariense strain JCM 13574 plasmid pJCM13574) position: , mismatch: 8, identity: 0.733

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
gccggttacgcccgtggcgccggtgccgtc	Protospacer
* ******** ******** ***** .  .

35. spacer 3.2|1666914|30|NZ_CP043006|CRT matches to NC_008382 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL7, complete sequence) position: , mismatch: 8, identity: 0.733

ggcggttacgaccgtggcggcggtggttat	CRISPR spacer
tgtggttatgtccgtggcggcggtggccgc	Protospacer
 *.*****.* ***************....

36. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP029452 (Sinorhizobium fredii CCBAU 25509 plasmid pSF25509b, complete sequence) position: , mismatch: 8, identity: 0.733

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
cacattcgtggtggcggtcgcgatcgcggt	Protospacer
*... . ***********..**********

37. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NZ_CP023071 (Sinorhizobium fredii CCBAU 83666 plasmid pSF83666b, complete sequence) position: , mismatch: 8, identity: 0.733

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
cacattcgtggtggcggtcgcgatcgcggt	Protospacer
*... . ***********..**********

38. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to MT310875 (Microbacterium phage Ashton, complete genome) position: , mismatch: 8, identity: 0.733

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
ggtggcggcggtggcggttacggcggctcg	Protospacer
 *******.*************.. **   

39. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to NZ_CP011276 (Planctomyces sp. SH-PL62 plasmid pPL62-3, complete sequence) position: , mismatch: 8, identity: 0.758

cgcggcggtggcggcggcggttatgaccgtggc	CRISPR spacer
ggcggcggaggcggcggcgggtatgcattcggc	Protospacer
 ******* *********** ****  . .***

40. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to AP014018 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S35-C77, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.758

cgcggcggtggcggcggcggttatg-accgtggc	CRISPR spacer
ggcggcggtggcggcggcagttttgcaatatgt-	Protospacer
 *****************.*** ** * ..**  

41. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to AP014019 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S39-C83, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.758

cgcggcggtggcggcggcggttatg-accgtggc	CRISPR spacer
ggcggcggtggcggcggcagttttgcaatatgt-	Protospacer
 *****************.*** ** * ..**  

42. spacer 3.7|1667157|36|NZ_CP043006|CRT matches to KU686197 (Synechococcus phage S-CAM3 isolate 0808SB25, complete genome) position: , mismatch: 8, identity: 0.778

cgtggcggtggcggcggtggatataatcgcggcggc	CRISPR spacer
cgtggaggtggcggcggtggatctaacgttggtggt	Protospacer
***** **************** ***.  .**.**.

43. spacer 3.7|1667157|36|NZ_CP043006|CRT matches to KU686199 (Synechococcus phage S-CAM3 isolate 1010CC42, complete genome) position: , mismatch: 8, identity: 0.778

cgtggcggtggcggcggtggatataatcgcggcggc	CRISPR spacer
cgtggaggtggcggcggtggatctaacgttggtggt	Protospacer
***** **************** ***.  .**.**.

44. spacer 3.7|1667157|36|NZ_CP043006|CRT matches to KU686198 (Synechococcus phage S-CAM3 isolate 0910TB04, complete genome) position: , mismatch: 8, identity: 0.778

cgtggcggtggcggcggtggatataatcgcggcggc	CRISPR spacer
cgtggaggtggcggcggtggatctaacgttggtggt	Protospacer
***** **************** ***.  .**.**.

45. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to NC_023285 (Streptomyces sp. F8 plasmid pFRL5, complete sequence) position: , mismatch: 9, identity: 0.7

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
ggtggcggaggtggcggtgacgatgatcag	Protospacer
 ******* ********* ***** .. . 

46. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to KM434186 (Pseudomonas phage vB_PaeM_PS24, complete genome) position: , mismatch: 9, identity: 0.7

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
gatggcggcggtggcggttacgaagccttc	Protospacer
 .******.**************   *  .

47. spacer 3.4|1667016|30|NZ_CP043006|CRT matches to MN694689 (Marine virus AFVG_250M951, complete genome) position: , mismatch: 9, identity: 0.7

cgtggcggtggtggcggttacgatcgcggt	CRISPR spacer
ggtggcggtggtggcggtgacggaacttct	Protospacer
 ***************** ***.   .  *

48. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to AY848687 (Enterobacteria phage PR5, complete genome) position: , mismatch: 9, identity: 0.727

cgcggcggtggcggcggcggttatgaccgtggc	CRISPR spacer
ggcggcggtggcggcggcggtggtgaatatatg	Protospacer
 ******************** .*** ..*.  

49. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to NC_011273 (Mycobacterium phage Myrna, complete genome) position: , mismatch: 9, identity: 0.727

cgcggcggtggcggcggcggttatgaccgtggc	CRISPR spacer
ggcggcggtggcggcggcggtaaggaaggctcg	Protospacer
 ******************** * **  *.   

50. spacer 3.7|1667157|36|NZ_CP043006|CRT matches to MN693933 (Marine virus AFVG_250M271, complete genome) position: , mismatch: 9, identity: 0.75

cgtggcggtggcggcggtggatataatcgcggcggc	CRISPR spacer
ggtggcggtggcggtggtggaaataatggacctggt	Protospacer
 *************.****** ***** *   .**.

51. spacer 3.7|1667157|36|NZ_CP043006|CRT matches to MN694544 (Marine virus AFVG_250M272, complete genome) position: , mismatch: 9, identity: 0.75

cgtggcggtggcggcggtggatataatcgcggcggc	CRISPR spacer
ggtggcggtggcggtggtggaaataatggacctggt	Protospacer
 *************.****** ***** *   .**.

52. spacer 4.1|2118669|34|NZ_CP043006|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 9, identity: 0.735

cttccgcggaaaacgctggcgagcagcggaacct	CRISPR spacer
cggccgcggaacacgctgccgagcagcgacggcc	Protospacer
*  ******** ****** *********. . *.

53. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to AP013470 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G18, isolate: uvMED-CGR-C56A-MedDCM-OCT-S32-C59) position: , mismatch: 11, identity: 0.667

cgcggcggtggcggcggcggttatgaccgtggc	CRISPR spacer
ggcggcggtggtggcggcggttctggtacaaat	Protospacer
 **********.********** **..   ...

54. spacer 3.6|1667106|33|NZ_CP043006|CRT matches to AP013751 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C56A-MedDCM-OCT-S46-C59, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 11, identity: 0.667

cgcggcggtggcggcggcggttatgaccgtggc	CRISPR spacer
ggcggcggtggtggcggcggttctggtacaaat	Protospacer
 **********.********** **..   ...

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	5902409 : 5911925	8	Staphylococcus_phage(16.67%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_CP043006|5902409:5911925|DBSCAN-SWA
TATGCAAATCAGCAGTGTAAGAGATACACTCAAGGAATTGCGAGATCTGGGCATTCAGAACGCCAACGATGTACATTACCAACTTAGCCCGGAAGAGCTGGTGGCACAAACCCTGGCACGCCGCCAGGGCAGCCTGAGCGACACGGGTGCGCTGGTAGTGAATACCGGAGAGTTTACAGGCCGTTCCCCGAAAGACAAGTTTATTGTAAAAGACAGCATTACTGCTGGTTCGGTAAACTGGAACGACTTCAACCTGCCTTTTTCTGCCGAAAACTTCGAGCGGCTGTATCAGAAAGTAACCAACCATTTTAAAGAAAAAGACGTTTGGGTAAGAGATTGCCAGGCCTGCGCCGATCCTGCTTACCGGATCAATATCCGTGTGATCAGCGAAACACCCTGGGCCAGCCTCTTTGCCTACAACATGTTCATCCGCCCCACCGAAGAGGAACTGGAACATTCGGACCCGGAATGGACCGTTATCCATGCACCGGGCTGCCATGCCGATCCCGCCGTGGACGGTACCCGTCAGCACAATTTTGCGGTACTGAATTTTACCCGGAGAATGATCATCATCGGCGGCTCCGCCTATACCGGCGAGATCAAAAAAGGTGTCTTCACCATTCTCAATTACCTGCTGCCACACAATAAAGGCGTATTGAGCATGCATTGCTCCGCCAACCAGGGCAGAGCAGGTGATACGGCTGTTTTCTTCGGACTCAGCGGCACCGGCAAGACCACACTGAGCGCCGATCCCGACCGCAAGCTCATCGGAGACGACGAACACGGATGGACCGATACCGGCGTTTTCAACTTTGAAGGCGGCTGCTATGCCAAAACCATCGACCTCAGCGAAGAAAAGGAACCTCAGATATTTCATGCCGTACGCGAAGGCGCACTGCTGGAAAATACAGGCTTCTATCCCGGCACACATACTGTTAACTATGCAGATAAAAGCATCACGGAAAACACCCGCGTATCTTACCCCCTGCATTATATCAGCAATGCCCAGGAACCATCCATCGGCAATATGCCGCGGAATATCTTCTTCCTGACCTGTGATGCCTACGGCGTGTTGCCACCCATTTCCAGGCTCACACCGGCCCAGGCCATGTACCAGTTCATCTCCGGCTACACCGCCAAGATTGCCGGTACGGAAGCAGGGATCACGGAACCCAAATCCACTTTCAGCGCGTGTTTCGGAGCGCCCTTCCTGCCGCTGCACCCCGGCCGTTATGCACTGATGCTGGGCGAAAAGCTGCGCCAGCACAATGTTAATGTATGGCTGGTGAACACCGGGTGGACCGGCGGGGCCTATGGCACCGGGGAACGCATCAGACTGAAGTACACCCGCGCCATGATATCCGCCGCGCTGAAAGGTGAGTTGGACAAGGCAGCCTACAAACACCATGAAGTGTTCGGCGTGGCCATTCCTGAAGCCTGCCCCGGTGTACCGGACGAAATTCTCGACCCGCGTAACACCTGGGAAGACAAAGCCGCTTACGACGCACAGGCACAGGATCTGGCAGAACAATTTGTAAGAAACTTCGAAAAATATGCCGACCAGGTGGATGAGGAAATCCTCCTGGCCGCACCCAGAATCTAATCGTTTATGTTGACCGTTTTCTTTTATAGATTCCCACGTTTTGAGTATAATCCGTAATGAAGCACGGGGGTTGCCTGGCCAGGCAGCCCCTTTTTGCAGCCCCTCCCCCCTATTTCACATTCCCATCTCAACATATTTTCCTAATTTTGCGCATGCAAATTTTAGACGGCAAACTCGTTTCAAAGGCGATCAAAGATCAAATAGCAGTCCAGGTGACTGAACTGAAAGCGCAAGGCAAAAAAATCCCCCATCTGGCTGCCATCCTGGTAGGCAACGACGGGGCCAGTGAGACCTATGTGGCCTCCAAGGTGAAGTCCTGCGCAGAGATCGGCTACAACTCCACCCTCCTGCGCTTCGACAGCCAGATATCCGAAAAGCATCTGCTCGATAATATCAATATGTTGAACGAAAACCCGGATATCGACGGCATCCTCGTTCAGCTCCCGCTTCCCAAACACATCAACGAAGAACTGGTGATCAACACCATCGATCCCAGCAAGGATGTGGATGGCTTCCACCCGGTAAATGTGGGTAAAATGGTCAGCGGGCTGCCCACTTTCATTCCTGCCACTCCTTACGGCATCATGCTGATGCTGGAACACTATAATATCGATACCAAAGGCAAACATGCGGTAGTGATAGGACGCAGCCACATCGTAGGCACCCCGGTAAGCATTCTGCTAAGCCGCAACAGCAATCCCGGCAACTGCACAGTAACGCTCACCCATTCCCACACGAGGAACCTGAAAGAGGTTTGTCTGCAGGCAGATATCATCGTTGCCGCCATTGGCCGGCCAGAATTCGTGACAGCGGACATGGTGAAAGAAGGCGCTATTATTGTTGACGTGGGCATCAACCGCATCCCGGATGCTTCCAAAAAAAGCGGGTTCCGGCTGGTAGGTGATGTGAAATTCGATGAAGTAGCCCCCCGCTCCAGCTTTATTACACCCGTACCCGGCGGCGTTGGCCCGATGACCATTGCCGCATTGCTGAAAAACACCTACCACGCGGCCATTGCCCAGAAAGGGAACCAGAACTGAGCGTGAACACACCGTTGTTCCATCCGGCTTCCACAGGCGGTAAATACTGTCCGTCCCGCATATTCCGTAACTTTGCACCGTAAATGAGCAACACCGTACTTCATACCGCCACCCTGCCCGTCATGGAATCGTTCTACACGATCCAGGGAGAAGGGTTCCACCAGGGCAAAGCAGCCTATTTCATCCGCCTCGGCGGATGCGATGTGGGTTGTGTGTGGTGCGATGTAAAAGAAAGCTGGGATGCGGACAAACATCCGCAAGTTCCGGTGATGGAAATCGTGCAGGAAGCGGCGGCATTCCCGGGCAGGATTGCCGTTATCACCGGCGGAGAACCGCTGATGCACAACCTCGACGGGCTGACGAAATCCCTGCATAAAACAGGCTTCCGGACGCATATCGAAACATCCGGCTCCTCTCCCATGAGCGGCAATTGGGACTGGATCACCCTCTCCCCGAAGAAATTCAAAGCCCCGCTGGATGAAGTCTGCAAACAGGCACATGAACTGAAGATCGTAGTGTACCATAAATCCGATTTTGCCTGGGCGGAGAAATACGCCGCACAGGTGGGCAAACAATGTAAACTCTATCTTCAGCCGGAATGGAGCCGCGCTGCCGAAATGACGCCGCTGATCATCGACTACGTAAAGGACCATCCGCAGTGGCAGATTTCGCTGCAGATACACAAGTATATCAATGTACCATAAAAAAAGCGCCTTGCTGTAAAGCAAAGCGCCAGACATTTTGGTTAACAACACTTCGTCAGGAAATCCTCCTGGTTTGCGGCAACAATCCGCTGTTCTCGATCGGCACCCATTCCACGATTTTGTCCAGCTTCACTTCAATCGAGTACAACCGTGATTCGATAGCATGGAAATGCGCTGAGAATTTGACATCCATGGCAATGAATTTAGTCTCGGTGCGATGCTCCATCGCAGAAAGCTTTCCATCCATGTTGACTTCAAGCGCCGAGATCTTCTCGTCTACCGAAACTTCGAATTGACCGAAGCGCTGATCGAGGTTTTCCACCTTTGCATCCAGCTGATCAAACCGTTGTTCCAGGTTTTCCACCTTGGTTTCAAGCTGATCGAACCGTTGTTCGAGGTTTTCCACCTTGACTTCCAGCTGATCGAACCGTCGTTCCAGATTTTCCACCTTTACTTCCAGCTGATCAAACCGCCGTTCCAGGTTGTCCACCTTCGCATCCAGCTGATCAAACCTGACTTCCAGACCCGAAACCTTCCTGTCAATTGCCCTTACACTTGTAAGGATCTCAGTTAACAAAACATTTTCGCTCATAAGTATGGTTTTAAAAATTTAACGAAATTACCTGAAATCGAAACAACATTCGTATTATGTGGTTAAACATCTAAAAAATTGCATCGCATCTTCTCAAAGTGAAACAGCCATCATCAGATTACTCATCATAAACCCCAAAAAAATTCGTTATTTAGTGATCAACTATGAAAAAACTCCTGCTCATACTTTGCTGCTTGACCAGCCTGCAGCTTGCCGCACAAACGGTCACTTACGAAACGGCCGGCAAAAAGGCCAAAGCGCTGTTCGACCAGGCTATTGACGCCATGCGCATGTACCAGCCCAAAGATGCGATCAGGTTCCTGCAGGAAGCCATCAAAGTACAACCGAAATTCGTAGATGCATATGGACAAATGGGGCTGGCCTATGTGGAGACCGGGCAATATCCCGATGCGCTGAACGCCTTCCGCCAGCTGGAAACACTGGACCCCGCAGGCGTCAGACATGTAAGGTTCTCCTATTCCAAAGCGCTCGCCGGTGACGGTCAGTTCAAAGAAGCACTGACCATGATCACGGAATATATTGAAACATCCAAAACACCCACGCAGGCTTCGCTGAAATTCAAAAAGAACATGGAGTTTGCCGTTACCCAAACACCGGTGCCGTTTCAGCCGCAGAACCTCGGAGAGAATATAAACTCCCCCGATCCCGAATATTTCCCTTCCCCCACCATCGATGGGAAGACGCTGGTGTACACCCGCCGCGTCAAAGGCAGGAACGAAGATTTCTTTGTTTCACAAAGGGACAGCCTGCAATGGCTTCCCGCAAAGGATATGGGGGAACCGGTGAACTCCGCTTTCAATGAAGGCGCACAGAACATTTCACAGGATGGCGAAATGCTGGTATTCACCGGCTGCGACTTCCCCGAAGGACGCGGCAGCTGCGATATCTACTATTCCATCAAAACAGCGGACGGCTGGCAGACGCCGAAAAACATCGGTAATGCGATCAATACCCGCGACTGGGATTCACAGCCCTGCCTGTCCCCGGACAAACAATCGTTATACTTCACCAGGGAAACTGCAGATGCCGGCGCGGACATCTTTGTCAGCCACCGCGGAGCTGACGGCCAATGGCAAAAAGCAGAACGCCTGGGCCCCGCCATCAATACGCCCGGCCGGGAGATGACGCCTTTTCTGCATGCAGACGGGCAAACGCTGTTCTTTGCTTCCGACGGCCATCCCGGTTATGGCAGCCTGGACATGTTCTATTCCCGCCGCCAGCCGGATGGCAGCTGGGGCACACCGATAAACCTCGGCTACCCGATCAACACCATCGGCGAAGATGCCAGCCTTACCGTAGCGGCAGACGGCAAAACCGCCTACTTCGCCTCCGACCGCGCGGATTCACGCGGTGCGCTGGATATCTACAGCTTCGAACTGTATGAAGCAGCCAGACCATTGCCCACGCTTTATGTAAGAGGGTATGTGTATGACAAAAAGACCAACGAGCGCCTTCCCGCCTCTTCACTTGAACTGGTGGACCTGGAAACGGAACTGACCATTGCGAATATACGCAGCGATGAACAGGGCGCTTTTCTTGTACCGCTGCCCACCGGGAAAGATTATGCTTTCAATGTCAACCGGAAAGGATACCTTTTTTATTCCGACAACTTCTCGCTTAAAACAGCACGAACAGATGAGCCGTTTGAGAAAAACATTCCGCTGCAACCGCTGGAAGCAAATGCTGTTGTAGTACTGCGGAACATCTTCTTTGCATCGAATCAATACACCCTGCAACCAGCCTCCGCTACGGAGCTGGACAAACTCGTAAAACTGCTCTCGGAGAATCCCACTATGCAGGCGGAGATCGGCGGGCATACGGACAATGTTGGCGCCGACGCGGACAACCAGCTATTGTCCGAAAACCGGGCAAAAGCGGTGGTGCAATACCTTGTGCAAAAAGGCATTGCAGCAGAAAGGCTGAAAGCAAAAGGGTTCGGCGAAACAAAACCTGTAGACACCAACGATACCGAAACCGGGCGTGCGCAGAACAGGCGAACAGAACTGAAGGTGATCAGCATGTAAAGGCGCCTGCGCTCAATACCCTTTGAGCGCGGCCTTCAACGCACTGTCCGCCCGTTGCTGATTTAACGGCGCCCCTTTCGGGTACAACGCGGAAAGCCAGTCCCCGTACATCACATTCGGCAACATGATGAACCTGCCCGCAAACTCCAGCCGCAGGCGGATGACAGCAGCATCCCGCTCTTCAGGGGCAGCTTTGTAGAACACATCGGAAAAATCGCCGAGATTATCACCGACCAGCATGGCTATTTCATATTGCTTCGCCACCTGCATGCGGCGCGCCTCCTTATCGGAACTACCGGAAGAAAGCAGCAGGTGTTCATCATCCGCCTGCGGAAATCCCCAACGCTGCAGGTTCCGCAATGTAGCGGCACGTTCCTTTTCCAGCCGGTTAGTGATGTAATAGATCGCAAATCCTTTTGATGCTGCATACCGGAAGAACGACAATGCACCTGGCACGGTATCACATGCAGCCCGGGCGGTCCACTCCTCCCACGAAGCCTGATCATACTGCCGGCCCTGCAGCGCGTAATGCACGGTAAACGGGCTGTTGTCCAGCACCGTTTCATCAATATCCGTTACAATAGCCCGCGGCCGCAGCGTTTGCTGATGGCTCATTTCTTCCACACGGATAGCGGCAAGCTGATAAGCTTGCAGGCATAACGCCTTGTACTCTGCGGCCCGTTGCTGATAAAGCGCACCCCAGGCAGGGCCGTAAGGCAGCAATGCCGTTCTTTTTGCGGTACTGCAGGCGGTAAACATCAACAGGAAAAATAGCAGGTAACGTGCGGGCATAATGATCTGTTTAAGCGATACAAACTTCGTGAAAATGCAGTACATTGACGGGCAATAAAAATTGTTTGCGAACCCATGCTACAGGAACTTCATTACCGTATAGCATTAACGCTCATCCCGCAGGTGGGCGATGTAGTAGCCAAAGAGCTGCTGTCTCATTTTGGAACGGCCACCGATATTTTTCAGGCGCGCAGGCATCAGCTGGAGCGCATACCGGGCGTTGGTACGTTCAGGGCTTCCGCTATCCGCGGGTTTAAAGATTTCGCGGAGGTGGACCAGGAGATCGGTTTCATGAACAGGCATGATATCCGGCCGGTGTTTTATACGGATGATGCATACCCCGAGCGCCTGCGGCAGTGTTACGACAGCCCGGTGCTGTTATACTGCAAAGGTTCGGCGGACCTCTGCGCACCCAGGATGCTGGGCATCGTAGGCACGCGGAAACCAACGGCTTATGGCCTTGCTGTATGCACTGAGCTGGTCGCTTCACTGGCGCCTCATAACGTAACGATCATCAGCGGCATGGCGTATGGTATTGATATTGCCGCGCACCGGGCCGCCGTGGCGCATGGGCTCCCCACCATCGGGGTGCTGGCGCACGGGCTGGACCGGCTGTACCCCGCTACACATGCGGCCACAGCGCGGCAGATGGAGCACAACGGCGGATTACTCACAGATTTTCGCAGCGGCACAGAGCCGAACCGGCAGAATTTTCCGCGGCGGAACCGTATCGTTGCCGGTCTATGTGATGCTACGCTGGTGATTGAAAGCGGTCAGCGCGGCGGGTCGCTCATTACGGCGGACATTGCCTGCAGCTATCACCGCGATGTGCTGGCCGTTCCGGGCAGAACGAATGATCCTGCTTCCGCCGGATGCCTGGAACTGATCAAACAACACAAAGCAGCCCTCATCACCTCAGCGGAAGATATCATGCAGGCGCTCAACTGGCGGCCCGCCGCGCCGGTAAAGCCCCTTGCACCACAAACCCACCTGTTTTACGATCTGAATGAAGAGCAACAGCTTATTGTGAAATTGCTGCAGGGCAATACTCCCCTGCATATCGATGAAATACAGGCCCGGAGCGGCATACCGCAGAACAGGATACCCGGTCTGTTACTGGAGCTGGAAATGCAGGCATTACTGCGGTCAATGCCCGGGAATACATATCAATTAATCAACACATAAAAAAATGAACTGTTCCTATTCCATAAAAAACACGTAGATTTGCGTGCAATTATTTAGAAAACTACCAAAATAATTGCGATATGCCTGCGGGAAAAATCAAACAGAAATTTGTAGCTGACGGCCTTACCTTTGACGATGTGCTTCTCGTCCCGGCCTATTCGGACGTACTGCCCAGAGAAGTCAATATCTCCTCCCAACTTACTAAAAACATCAGGATCAACATCCCTATGGTATCCGCCGCAATGGATACGGTAACTGAAGCCAGGCTTGCGATTGCGCTGGCCAGAGAAGGCGGCATCGGCATTCTGCACAAGAACATGAGCATCGACAAGCAGGCGGAACTGGTAAGGAAAGTGAAACGCAGCGAGAGCGGCATGATCCTGGACCCGCTGACGCTCAGCGCGGACTCCACTATCGGGCAGGCTTTGAAAATGATGCGGGATAACGGTATTGGTGGTATCCCCATCGTAGATGGCGATAAAAAACTCATCGGCATCCTCACCAACCGGGACCTCCGCTTCGAGAAATCCAACAAACGCCTGATCAGTGAAGTGATGACGAAGGACAACCTGGTCACCGCTCCTGAAGGCACCGATCTGAAAAAGGCAGAAAAGATCCTCCAGCAACATCGCATTGAGAAATTACCGGTAGTTAACAAACAGGGCAAGCTCGTAGGCCTCATTACCTATCGCGATATCCTCCAGCTGCAAAGCTTTCCGAATTCCGCAAAAGACAGTTACGGCCGCCTGCTCGTAGGCGCCGCGCTCGGCATCACGCATGATCTGCAGGAACGCGCCGCCGCGCTGCTGCATGTTGGTGTGGATGTGGTGACGCTGGACAGTGCGCACGGTCATTCCGTTCACGTACTGGAAGCCTTGAAAAAACTGAAGAAAGCATTCCCGAAACTGCAGGTGATCGGCGGTAATGTAGCCACCGCGGAAGGAGCGCTGGCACTGGCCGCAGCTGGCGCCGATGCCGTAAAAGTAGGCGTTGGTCCGGGTTCTATCTGCACCACCCGCGTGGTGACCGGCGCAGGTTTCCCGCAGCTTTCAGCCATCATGAACGCCGCCCAGGCCCTGAAAAAATCCGGCATTCCGGTGATCGCGGACGGCGGTATCAGATATACCGGCGATATGGTAAAAGCTTTTGTAGCCGGAGCCTCCACCGTCATGGCAGGGTCCATCTTTGCCGGCGTGGAAGAAAGTCCCGGTGAAACGATCATCTACGAAGGCCGCAAATTCAAATCCTACCGCGGCATGGGCTCCATCGAAGCCATGTCCGAAGGCAGCAAAGACCGCTACTTCCAGGATGTGGAAGCGGATATCAAAAAGCTGGTGCCGGAAGGCATTGTGGGCAGAGTGCCTTACAAAGGCAACCTTTCCGAAGTAGTGCAGCAATTTGTGGGCGGCCTCCGTGCAGGAATGGGCTACAGCGGGTCAAAAGACATCAAAACCCTCCAGGAAGCCCAGTTCGTCAGGATCACCTCCGCTACCGTAAGGGAAAATCACCCCCATGATGTGGTGATCACCAAGGAAGCGCCGAACTACAGCAGATAA

Protein sequences of DBSCAN-SWA_1

>NZ_CP043006|5902409:5911925|5905173_5905755_+|WP_148390064.1|DBSCAN-SWA
MESFYTIQGEGFHQGKAAYFIRLGGCDVGCVWCDVKESWDADKHPQVPVMEIVQEAAAFPGRIAVITGGEPLMHNLDGLTKSLHKTGFRTHIETSGSSPMSGNWDWITLSPKKFKAPLDEVCKQAHELKIVVYHKSDFAWAEKYAAQVGKQCKLYLQPEWSRAAEMTPLIIDYVKDHPQWQISLQIHKYINVP
>NZ_CP043006|5902409:5911925|5904163_5905051_+|WP_148389590.1|DBSCAN-SWA
MQILDGKLVSKAIKDQIAVQVTELKAQGKKIPHLAAILVGNDGASETYVASKVKSCAEIGYNSTLLRFDSQISEKHLLDNINMLNENPDIDGILVQLPLPKHINEELVINTIDPSKDVDGFHPVNVGKMVSGLPTFIPATPYGIMLMLEHYNIDTKGKHAVVIGRSHIVGTPVSILLSRNSNPGNCTVTLTHSHTRNLKEVCLQADIIVAAIGRPEFVTADMVKEGAIIVDVGINRIPDASKKSGFRLVGDVKFDEVAPRSSFITPVPGGVGPMTIAALLKNTYHAAIAQKGNQN
>NZ_CP043006|5902409:5911925|5902409_5904011_+|WP_148389589.1|DBSCAN-SWA
MQISSVRDTLKELRDLGIQNANDVHYQLSPEELVAQTLARRQGSLSDTGALVVNTGEFTGRSPKDKFIVKDSITAGSVNWNDFNLPFSAENFERLYQKVTNHFKEKDVWVRDCQACADPAYRINIRVISETPWASLFAYNMFIRPTEEELEHSDPEWTVIHAPGCHADPAVDGTRQHNFAVLNFTRRMIIIGGSAYTGEIKKGVFTILNYLLPHNKGVLSMHCSANQGRAGDTAVFFGLSGTGKTTLSADPDRKLIGDDEHGWTDTGVFNFEGGCYAKTIDLSEEKEPQIFHAVREGALLENTGFYPGTHTVNYADKSITENTRVSYPLHYISNAQEPSIGNMPRNIFFLTCDAYGVLPPISRLTPAQAMYQFISGYTAKIAGTEAGITEPKSTFSACFGAPFLPLHPGRYALMLGEKLRQHNVNVWLVNTGWTGGAYGTGERIRLKYTRAMISAALKGELDKAAYKHHEVFGVAIPEACPGVPDEILDPRNTWEDKAAYDAQAQDLAEQFVRNFEKYADQVDEEILLAAPRI
>NZ_CP043006|5902409:5911925|5905810_5906347_-|WP_148389591.1|DBSCAN-SWA
MSENVLLTEILTSVRAIDRKVSGLEVRFDQLDAKVDNLERRFDQLEVKVENLERRFDQLEVKVENLEQRFDQLETKVENLEQRFDQLDAKVENLDQRFGQFEVSVDEKISALEVNMDGKLSAMEHRTETKFIAMDVKFSAHFHAIESRLYSIEVKLDKIVEWVPIENSGLLPQTRRIS
>NZ_CP043006|5902409:5911925|5908404_5909184_-|WP_168208959.1|DBSCAN-SWA
MPARYLLFFLLMFTACSTAKRTALLPYGPAWGALYQQRAAEYKALCLQAYQLAAIRVEEMSHQQTLRPRAIVTDIDETVLDNSPFTVHYALQGRQYDQASWEEWTARAACDTVPGALSFFRYAASKGFAIYYITNRLEKERAATLRNLQRWGFPQADDEHLLLSSGSSDKEARRMQVAKQYEIAMLVGDNLGDFSDVFYKAAPEERDAAVIRLRLEFAGRFIMLPNVMYGDWLSALYPKGAPLNQQRADSALKAALKGY
>NZ_CP043006|5902409:5911925|5909259_5910369_+|WP_148389594.1|DBSCAN-SWA
MLQELHYRIALTLIPQVGDVVAKELLSHFGTATDIFQARRHQLERIPGVGTFRASAIRGFKDFAEVDQEIGFMNRHDIRPVFYTDDAYPERLRQCYDSPVLLYCKGSADLCAPRMLGIVGTRKPTAYGLAVCTELVASLAPHNVTIISGMAYGIDIAAHRAAVAHGLPTIGVLAHGLDRLYPATHAATARQMEHNGGLLTDFRSGTEPNRQNFPRRNRIVAGLCDATLVIESGQRGGSLITADIACSYHRDVLAVPGRTNDPASAGCLELIKQHKAALITSAEDIMQALNWRPAAPVKPLAPQTHLFYDLNEEQQLIVKLLQGNTPLHIDEIQARSGIPQNRIPGLLLELEMQALLRSMPGNTYQLINT
>NZ_CP043006|5902409:5911925|5910449_5911925_+|WP_148389595.1|DBSCAN-SWA
MPAGKIKQKFVADGLTFDDVLLVPAYSDVLPREVNISSQLTKNIRINIPMVSAAMDTVTEARLAIALAREGGIGILHKNMSIDKQAELVRKVKRSESGMILDPLTLSADSTIGQALKMMRDNGIGGIPIVDGDKKLIGILTNRDLRFEKSNKRLISEVMTKDNLVTAPEGTDLKKAEKILQQHRIEKLPVVNKQGKLVGLITYRDILQLQSFPNSAKDSYGRLLVGAALGITHDLQERAAALLHVGVDVVTLDSAHGHSVHVLEALKKLKKAFPKLQVIGGNVATAEGALALAAAGADAVKVGVGPGSICTTRVVTGAGFPQLSAIMNAAQALKKSGIPVIADGGIRYTGDMVKAFVAGASTVMAGSIFAGVEESPGETIIYEGRKFKSYRGMGSIEAMSEGSKDRYFQDVEADIKKLVPEGIVGRVPYKGNLSEVVQQFVGGLRAGMGYSGSKDIKTLQEAQFVRITSATVRENHPHDVVITKEAPNYSR
>NZ_CP043006|5902409:5911925|5906511_5908392_+|WP_148389592.1|DBSCAN-SWA
MKKLLLILCCLTSLQLAAQTVTYETAGKKAKALFDQAIDAMRMYQPKDAIRFLQEAIKVQPKFVDAYGQMGLAYVETGQYPDALNAFRQLETLDPAGVRHVRFSYSKALAGDGQFKEALTMITEYIETSKTPTQASLKFKKNMEFAVTQTPVPFQPQNLGENINSPDPEYFPSPTIDGKTLVYTRRVKGRNEDFFVSQRDSLQWLPAKDMGEPVNSAFNEGAQNISQDGEMLVFTGCDFPEGRGSCDIYYSIKTADGWQTPKNIGNAINTRDWDSQPCLSPDKQSLYFTRETADAGADIFVSHRGADGQWQKAERLGPAINTPGREMTPFLHADGQTLFFASDGHPGYGSLDMFYSRRQPDGSWGTPINLGYPINTIGEDASLTVAADGKTAYFASDRADSRGALDIYSFELYEAARPLPTLYVRGYVYDKKTNERLPASSLELVDLETELTIANIRSDEQGAFLVPLPTGKDYAFNVNRKGYLFYSDNFSLKTARTDEPFEKNIPLQPLEANAVVVLRNIFFASNQYTLQPASATELDKLVKLLSENPTMQAEIGGHTDNVGADADNQLLSENRAKAVVQYLVQKGIAAERLKAKGFGETKPVDTNDTETGRAQNRRTELKVISM

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148389589.1|5902409_5904011_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	4.3e-152	51.7
WP_148389590.1|5904163_5905051_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	1.1e-32	34.3
WP_148390064.1|5905173_5905755_+	radical SAM protein	A0A142F2D5	Mycobacterium_phage	5.2e-15	40.2
WP_148389591.1|5905810_5906347_-	hypothetical protein	NA	NA	NA	NA
WP_148389592.1|5906511_5908392_+	OmpA family protein	G3M9Z0	Bacillus_virus	4.0e-08	35.7
WP_168208959.1|5908404_5909184_-	5'-nucleotidase, lipoprotein e(P4) family	NA	NA	NA	NA
WP_148389594.1|5909259_5910369_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	7.5e-23	36.5
WP_148389595.1|5910449_5911925_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	4.9e-94	40.7