CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP043039	Leptospira interrogans serovar Hardjo strain L53 chromosome 2, complete sequence	2 crisprs	csa3	0	4	0
NZ_CP043041	Leptospira interrogans serovar Hardjo strain L53 chromosome 1, complete sequence	18 crisprs	WYL,csa3,DinG,cas3,cas6,cas1,cas2,cas8b3,cas7,cas5,cas8c,cas4,Cas9_archaeal	1	12	286
NZ_CP043040	Leptospira interrogans serovar Hardjo strain L53 plasmid p1	0 crisprs	NA	0	0	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP043039_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043039_1

11319-11509

Orphan

Consensus_repeat	Method
TAAAATGTAGGAACTC	PILER-CR

3 spacers

The CRISPR arrays of NZ_CP043039_1

>merge|NZ_CP043039|1|11319-11509|PILER-CR
TAAAATGTAGGAACTCTAACCAAAAGCCTCTGATAATAGATAGGGATCTATTTTAAGAGACTTAATATGTGGGAACTACCACAAATTTATGTTGTACAGTTATATTTTAAAAAACGTAGGAACTCATACAAAGCTCAATCACGAAAAATGAACGTTTAAAATCCGTAATGTGACTTAATATGTAGGAACTC

>NZ_CP043039|1|1|11319-11509|PILER-CR
TAAAATGTAGGAACTC	TAACCAAAAGCCTCTGATAATAGATAGGGATCTATTTTAAGAGACT
TAATATGTGGGAACTA	CCACAAATTTATGTTGTACAGTTATATTTTA
AAAAACGTAGGAACTC	ATACAAAGCTCAATCACGAAAAATGAACGTTTAAAATCCGTAATGTGACT
TAATATGTAGGAACTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043039.1\|WP_000070243.1\|23002_23398_-\|DUF4279-domain-containing-protein	unknown	unknown	gnl\|CDD\|372913
NZ_CP043039.1\|WP_000054149.1\|4432_5299_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376892
NZ_CP043039.1\|WP_001068299.1\|22353_22683_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_000424716.1\|3580_4423_-\|polyamine-aminopropyltransferase	unknown	unknown	gnl\|CDD\|234843
NZ_CP043039.1\|WP_000176203.1\|15886_16615_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP043039.1\|WP_000849259.1\|23626_24352_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP043039.1\|WP_000515894.1\|5398_5776_-\|S-adenosylmethionine-decarboxylase-proenzyme	unknown	unknown	gnl\|CDD\|235105
NZ_CP043039.1\|WP_000509033.1\|2741_3569_-\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|273987
NZ_CP043039.1\|WP_001074464.1\|19803_20955_-\|OmpA-family-protein	unknown	unknown	gnl\|CDD\|143586
NZ_CP043039.1\|WP_000755935.1\|10116_10908_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377040
NZ_CP043039.1\|WP_000134210.1\|24920_25484_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_001972541.1\|6852_7992_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NZ_CP043039.1\|WP_000561026.1\|21130_22147_-\|EF-P-lysine-aminoacylase-GenX	unknown	unknown	gnl\|CDD\|273090
NZ_CP043039.1\|WP_000863304.1\|17261_19535_-\|aconitate-hydratase	unknown	unknown	gnl\|CDD\|273561
NZ_CP043039.1\|WP_002111654.1\|1306_2509_+\|DUF1566-domain-containing-protein	unknown	unknown	gnl\|CDD\|377878
NZ_CP043039.1\|WP_000875950.1\|6250_6739_-\|DUF2505-family-protein	unknown	unknown	gnl\|CDD\|378476
NZ_CP043039.1\|WP_000603280.1\|14884_15502_+\|lytic-transglycosylase-domain-containing-protein	unknown	unknown	gnl\|CDD\|381594
NZ_CP043039.1\|WP_001157561.1\|8042_9188_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|214724
NZ_CP043039.1\|WP_011069803.1\|11854_12454_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185594
NZ_CP043039.1\|WP_001012308.1\|9208_10120_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043039.1\|WP_000070243.1\|23002_23398_-\|DUF4279-domain-containing-protein	gnl\|CDD\|372913	pfam14106, DUF4279, Domain of unknown function (DUF4279). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	3.92826e-20
NZ_CP043039.1\|WP_000054149.1\|4432_5299_-\|hypothetical-protein	gnl\|CDD\|376892	pfam02675, AdoMet_dc, S-adenosylmethionine decarboxylase. This family contains several S-adenosylmethionine decarboxylase proteins from bacterial and archaebacterial species. S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesized as a proenzyme, which is cleaved post translationally to form alpha and beta subunits. The alpha subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity.	3.5503e-22
NZ_CP043039.1\|WP_000424716.1\|3580_4423_-\|polyamine-aminopropyltransferase	gnl\|CDD\|234843	PRK00811, PRK00811, polyamine aminopropyltransferase.	7.39147e-142
NZ_CP043039.1\|WP_000176203.1\|15886_16615_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.75179e-13
NZ_CP043039.1\|WP_000849259.1\|23626_24352_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.13958e-82
NZ_CP043039.1\|WP_000515894.1\|5398_5776_-\|S-adenosylmethionine-decarboxylase-proenzyme	gnl\|CDD\|235105	PRK03124, PRK03124, S-adenosylmethionine decarboxylase proenzyme; Provisional.	2.59568e-73
NZ_CP043039.1\|WP_000509033.1\|2741_3569_-\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|273987	TIGR02127, Orotidine_5'-phosphate_decarboxylase, orotidine 5'-phosphate decarboxylase, subfamily 2. This model represents orotidine 5'-monophosphate decarboxylase, the PyrF protein of pyrimidine nucleotide biosynthesis. See TIGR01740 for a related but distinct subfamily of the same enzyme. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis].	2.43044e-128
NZ_CP043039.1\|WP_001074464.1\|19803_20955_-\|OmpA-family-protein	gnl\|CDD\|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	7.36581e-31
NZ_CP043039.1\|WP_000755935.1\|10116_10908_+\|hypothetical-protein	gnl\|CDD\|377040	pfam03448, MgtE_N, MgtE intracellular N domain. This domain is found at the N-terminus of eubacterial magnesium transporters of the MgtE family pfam01769. This domain is an intracellular domain that has an alpha-helical structure. The crystal structure of the MgtE transporter shows two of 5 magnesium ions are in the interface between the N domain and the CBS domains. In the absence of magnesium there is a large shift between the N and CBS domains.	0.00551799
NZ_CP043039.1\|WP_001972541.1\|6852_7992_+\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	7.37092e-151
NZ_CP043039.1\|WP_000561026.1\|21130_22147_-\|EF-P-lysine-aminoacylase-GenX	gnl\|CDD\|273090	TIGR00462, genX, EF-P lysine aminoacylase GenX. Many Gram-negative bacteria have a protein closely homologous to the C-terminal region of lysyl-tRNA synthetase (LysS). Multiple sequence alignment of these proteins with the homologous regions of collected LysS proteins shows that these proteins form a distinct set rather than just similar truncations of LysS. The protein is termed GenX after its designation in E. coli. Interestingly, genX often is located near a homolog of lysine-2,3-aminomutase. Its function is unknown. [Unknown function, General].	3.37946e-115
NZ_CP043039.1\|WP_000863304.1\|17261_19535_-\|aconitate-hydratase	gnl\|CDD\|273561	TIGR01340, Homocitrate_dehydratase_mitochondrial, aconitate hydratase, mitochondrial. This model represents mitochondrial forms of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. [Energy metabolism, TCA cycle].	0
NZ_CP043039.1\|WP_002111654.1\|1306_2509_+\|DUF1566-domain-containing-protein	gnl\|CDD\|377878	pfam07603, DUF1566, Protein of unknown function (DUF1566). These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.	4.76751e-32
NZ_CP043039.1\|WP_000603280.1\|14884_15502_+\|lytic-transglycosylase-domain-containing-protein	gnl\|CDD\|381594	cd00254, LT-like, lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	1.68259e-52
NZ_CP043039.1\|WP_001157561.1\|8042_9188_+\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|214724	smart00563, PlsC, Phosphate acyltransferases. Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.	2.26597e-09
NZ_CP043039.1\|WP_011069803.1\|11854_12454_-\|hypothetical-protein	gnl\|CDD\|185594	PTZ00395, PTZ00395, Sec24-related protein; Provisional.	0.00494851
NZ_CP043039.1\|WP_000875950.1\|6250_6739_-\|DUF2505-family-protein	gnl\|CDD\|378476	pfam10698, DUF2505, Protein of unknown function (DUF2505). Members of this family are all Actinobacteria. The function is not known.	0.000148185

>NZ_CP043039.1|WP_000755935.1|10116_10908_+|hypothetical-protein
MKKVINQIGKALEYLDKLGTGKSFQLFRSLGYEKLYSLSEKVDHKNLLYISQNLDEQTIIEFLNRIPEETLVDLISKVPPEDITYFANSIPMDDLVLLSTSIPAKFIAEMSLKTGKESATELLKNIGTQKSIELLNEVGIQNFIELSLKVPTIELIPIVRELTPKQSGAWVRKRGIGDIPKLIKAFGVQNLLVFLRTLGFEKNIHIMDVLGLEELIELAYTISGMKLPGLSTSGKKQKKVSKKIPKQSQKKTSSPWKKNIRKF
>NZ_CP043039.1|WP_001012308.1|9208_10120_+|hypothetical-protein
MNFWKRLFSSKREYRSAAKIWIEDPEKLQKSIHRIFDLLFDSTLKELMPEKIFFSLESLNGIKIPEDKIKTILKEINITETFPFHSASDVMSLETQEAILKFATGTVAAPSKFFLMKILNQSPIQEMFSLGLEKILLEFNKKLNPLASMFQAAGFEKQISGFLSTLLPGFTEKIAELIHNSSESETGKIFISNTLKILFQTGFSDLGHLESSDFRKHLEKLKEAISKDPILEKNLEKLYESFRDTILNEYRGETLKEFLGYSEKEYILFRDSVSKTTAENILAIHKQKPLTELVAGLLEDVLG
>NZ_CP043039.1|WP_001157561.1|8042_9188_+|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MQENSVIDKNSGTTQIVHSTNTYNWLIGIVYKTTGIFFDSIEEYFSQNNHDKILRAPYPTVIMGNHVEEGDVPALSVIHRVVQPKIKFAIPAREDILKKDFLVKEFRPKGTLKLILGMIDKTNLIPIFLKYIGCFPVKRPFRDNARELLKSGELRNMVDQEWSSLIERVSSGRNLFLFPEGTYNHDGYLNQIKKGVYFIRTKIKDVHFISFTLTYDYISAKKTQLHIAYGENFEIPENINSDEVISIVKERLGKNYVVTPGNLLSMILMRLSTEAAIGKEVLFKRLQNFATEIKKRGKEIHVSGKLFSSHLEDTFQNILKKGLESKLLKLNGNGEILGTEKLIQQEGNDIRNLKKRNILLYHSNQLTYHKPELDKIFISLT
>NZ_CP043039.1|WP_001972541.1|6852_7992_+|alanine-racemase
MKDTYSSWIEISKRSLSNNLDNFRSILRPNSTLTAILKSNAYGHGIEPMTRLCIEAGISRIGVNSIEEALLIRNIDSKIPILIMGEIQNPEKRKDVLSDPNFWIVFSRPETARILSSFLPAPKLHLKIDTGMGRLGSHGETLKQTLSELKNVGITLGGICTHFASTEDVLEHKYSLMQTQKFEEAIFLAKSFGYNHLIRHACASASTMLFPNAHFDMVRIGISLYGLWPSIQTRLSLNLTGNKNFQLNPILSWKSRIVHIQYHPADSYIGYGSTFQTSYPTKVAIVPVGYYEGLDRKLSSNGDMLVLGKKARIIGRICMNMTMLDVTHIPGAEVGSIVTIIGQDGEESITADDLADRTHTINYEVMTRISESIPRIVVD
>NZ_CP043039.1|WP_000875950.1|6250_6739_-|DUF2505-family-protein
MKYKVVQQFPVPLQNLLKAREDRYKYLDKFPELKNVELIEEKKEGNLVYQKRKVKLAESMPKVLATLLSDPSLLENSTFNLETNTHEFTLAPPGNENILKISGVSVYKELGPDKSERSYDVEVKSGVFLMGAAIEAVIEEVHKHSLEKDRNSISEFLKSYQS
>NZ_CP043039.1|WP_000515894.1|5398_5776_-|S-adenosylmethionine-decarboxylase-proenzyme
MGKHVIAEFYECDYETINNHELVEDIMLKSVDLSGATTIKSVFHRFSPYGVSGVVVVSESHFAIHTWPEYGYCAVDVFTCGDLIDNQAALDYLKEKFGSKNVSVVEMKRGVLNLGVDLHHKPVGN
>NZ_CP043039.1|WP_000054149.1|4432_5299_-|hypothetical-protein
MSLKTRETQKLVTRFSYLRNSLEIQTTDSGETYLSTREPIPVGEVVAVWGGKAVHKDELAGLSGLSTPHRVNRDFYLVSPLHDDGIDSIHLIRQKEDANCGYQGDITLVALRDIAAGEEISFHPAMHSPELALSKGKNSDAFRTRFYKHFPTYIQSQIDSNEELKVHPAFVEGAWGLLTSIDLESCNPALIRDADAIRRYVLELCDLIEMKRFGETVVVHFGEDERVAGYSMFQLIETSCISAHFANETNTSYIDIFSCKCYDPKVAAEFTRKFFQGDAMRLTVTNRF
>NZ_CP043039.1|WP_000424716.1|3580_4423_-|polyamine-aminopropyltransferase
MELWLDEALELKNGRALKIKVKEFLHSRTTPFQKIDVFESVGFGRMFTLDGVVMMTEADEFAYHEMIVHVPMMSHPNPEKVLVIGGGDGGTVREVLKHPSVKEVHLCEIDKGVIDVCYEYFPEIANAMKDPRVKHAYEDGAKYVKDYQNYFDCIMVDSSDPVGPAEVLFKRPFYETMANCLKEGGICTTQGESFYYHGSIIRELFNFIPEIFKHCGYYYTVVPTYPSGIIGFTYCSKGPDPYTVVPDPQRVPQGLKYYSAEMHKAAFVLPQFAQKHIVRK
>NZ_CP043039.1|WP_000509033.1|2741_3569_-|orotidine-5'-phosphate-decarboxylase
MGGKMNFQSKFLTRSQSLKSLLCVGLDPDFDKLPEIVKRSPEPLVQFCKEIIDATASYAVAYKPNIAFFEVFGSSGIRQFEKVIGHLKSNYPQIPIVADVKRGDLDNTARQYAKYYFGDLQVDSLTLSPYMGLDSIRPFLEYQDYLIFWLCLTSNPDSAQFQKKRFSETGRTLYEEVVYVANLVAISNLGFVVGATSPSELETLRTQNPNRIFLIPGFGAQGAKLENLLPVCGRNSLINSSRGIHFASNGSDFAARAGQEAEKIHKMMQTHFIGL
>NZ_CP043039.1|WP_002111654.1|1306_2509_+|DUF1566-domain-containing-protein
MYKYFIFIALLFFSFCIKSPAVLDPPYFILQYLQNVNSTENQGNNSNNNNSQCPAPAGPFNPGAIFDTGQTLCWNGAGTVQTCALWLPGADGDFNNVPNARSFVGPTQHCKFTSDYTIFDPLHGLTWKACAQGQTGSDCSGSVAAPINWANANAGLSGSCTELNTLNSGEGYAGRTNWRIPTVRELASIVHYTNNPHIENAFFPSRTFTGRPYMTSTIDARAAGNNWAIDFSVAPPMDVRILSTAQATSIYLRCVSGNAMPATSFVDQGDGTIRDLNTGLLWAQCSEGQGGVGCMFGGIGSLDWNQARGNCNGKVLVPGRVWRLPNINELLSIIDYSDPNPILPTIDTTFFPNTPNPSGYWTSTTYDSNKSLAIAVAFGNGIVATSDKSGNLYARCVTTF
>NZ_CP043039.1|WP_011069803.1|11854_12454_-|hypothetical-protein
MFFLEEEKILKNDSSENVSLSNGLSRSTVIRREDSLFESGNFLNFTESEDLPVTNISSTNTPKNEYSTLSSEEKDRIRKEVIQRVKSLADRFPDNSLIPRELTKTQEDKRKKDEERISEVRIALLEGREVIKPEMEFYLDSKIKKTKDMVEILEYSMKFFQDSRKNDQDSSLKLIEERLVSLQKSREELVLAKKKLDIP
>NZ_CP043039.1|WP_000603280.1|14884_15502_+|lytic-transglycosylase-domain-containing-protein
MILREYSERHNMRIEEIPNVQLVLSRIQEIENRFVKEAPTQSKEQTKNSFDSILKSEQEKSISSLEKEKNFGKDLKNIEPSLAKIIHQESEKNNLDPRLVQSVIKAESDFKTDAVSPKGAIGLMQLMPSTANLLGVEDPFDPAENVAGGTKFLSNLLNKYKNLDHALAAYNAGPSAVDRYAGIPPYKETRNYVEKVKKFYSSNTE
>NZ_CP043039.1|WP_000176203.1|15886_16615_+|TetR/AcrR-family-transcriptional-regulator
MTLSTVLTFIGSKMKSLKSKVNVRTKDNVISEAMIRKRDRAATETAILLAAIQVFAKKGYDGANTKDIAKVANANEALIFRYFGNKKGLLEAILTRSEKIKKENSRRISKNSESYIDIEASLQRMISRKCKDFKEAEDFMKVAVSQVILDSEVSRIIQRKIYTKIIPEFMGELEKFKKMGKIDSKADLKSVAYAISSLTFALGFMGQCVYKMPPTEIQAAIKETARIFRKGLEPESVKKRSK
>NZ_CP043039.1|WP_000863304.1|17261_19535_-|aconitate-hydratase
MAFDIEMIRARYDKIGVLVTKARNVVGRPLTLTEKILYSHLWEGEPKTAYEKGKSYVDFAPDRVAMQDATAQMALLQFMSAGRSKVAVPSTVHCDHLIQAKDGAAEDLKTANTINKEVYDFLSSVSNKYGIGFWKPGAGIIHQVVLENYAFPGGMMIGTDSHTVNAGGLGMIAIGVGGADAVDVMAGMAWELKFPKLIGVKLTGKLSGWASAKDIILKVAGILTVKGGTGAIVEYFGEGADSLSCTGKGTICNMGAEIGATTSVFGYDRNMREYLLKTNRKEVADLADKIAEHLTGDKEVYANPSQYFDQVIEINLSELEPYINGPFTPDLATPLSKFKEAVQQNGWPTNLEVGLIGSCTNSSYEDITRAASVAKQAADKNLEVKAEYTVTPGSEMIRYTIERDGLIKTFSDIGGVVLANACGPCIGQWSRHTKDPERKNSIITSFNRNFAKRNDGLAGTHAFVASPEIVTAFAIAGKLDFNPITDSLKTKDGKEVKLDPPTGLDFPPNGFDVKDAGFIAPAADGSKVTVAVDPKSDRLQLLSPFIPWEKTDLKGLKLLIKAKGKCTTDHISMAGPWLKYRGHLDNISNNLLIGAVNSFNDKTNEVKNQLSGAYEPVPQTARAYKAKGIGSIVVGDENYGEGSSREHAAMEPRHLGVRAVIVKSFARIHETNLKKQGMLALTFADKSDYDKIQEEDSIDILGLTSFQEGVPLTLVLHHKDGSSQEIKANHTFNSQQIAWFKAGSALNLISEEQNKKG
>NZ_CP043039.1|WP_001074464.1|19803_20955_-|OmpA-family-protein
MAKKENYYITIKGRKYDRKLIQLAEEFTSGKRDGKISINDAKRLLKIVKDNNAYTDIEKHTIEYIRENYKFTEKSDEWFRSEIRKWAAKKVQEAKKKSDVESILVDDSEAPEINFPSSWGEDKTEVVEITQTSTIGWRENSNFSSATSHSKKNKKIIPTLIFLSGFLILVGLVYFFRTLFYKEDLEQVVKTNSEIVSNSKEKQSDVSIEKAESTKEVRKKNVRSKKEESEIPKNALTILKPQTGKKLESKSLFSSLTNQNSTEEFSSNPQFREIESNVIRFEKNSIQIHKESRPSLNRLARWMKQDSSIRVKVIGHTSLEGSEDANQKVSLLRAQTVRNYIAGNGISKDRFEIIPKGASVPIGDNSKEEGKEMNRRVELRIYN
>NZ_CP043039.1|WP_000561026.1|21130_22147_-|EF-P-lysine-aminoacylase-GenX
MIALLNRRKSTKSKMNELSQEVLIQRAKFLSVLRKFFEKRNYLEMDTPCLKPVPSMEPYLDPFLVRSPSKKEKGYLITSPEYSLKEILSKGLEKIYEITHTFRSGEEGSPFHSAEFLMLEFYTVGITLEGLMDFCTDLLEVLDQEFYSYGFNREQVQRMSVEESLKRYAFCGISKSELDRVITEHTLSEIPAEKRAYEDSFFIVFLNLVEKHLPKGFTFLYDYPPELAALSKIRSGFAKRFELYFGNLELGNAFEELTDPIEQISRFRSERELRKNLGKEVYAIDSGLERALKEGIPDSCGISIGLDRLLLCILGGSSLREVSPYYGKFLNFQIRSED
>NZ_CP043039.1|WP_001068299.1|22353_22683_+|hypothetical-protein
MNPIQRYERFEIKRNRQSTEVTPLISSFDEVTLDELKSVLALLFYQSNLHVKINLHEIKVLPLPAAMKLISFAFDLRLKNRTLVISGASVSLKKLIQFYRMDKVILVLS
>NZ_CP043039.1|WP_000070243.1|23002_23398_-|DUF4279-domain-containing-protein
MSNPLTWAILSVNEDDLDSESVTRELGLEPDFSTPIDVTDKEGKPLGFGHWQLHSTLSAEEPLEEHILQILEKVLPSRHKVKEFGTKHSLCLYVSVEFSDFSKQETEISSRILLLLGNLGIKLVFQPWQKE
>NZ_CP043039.1|WP_000849259.1|23626_24352_+|response-regulator-transcription-factor
MKTILVIEDDPDIGNLIRKSLDSAHYSTTLQTSGEEGLKFYKANHPDMVILDLSLPDIDGIEVCRTVRRNDENTPIFIVTARNEEIDRIMGLELGADDYITKPFSVRELKTRVDVFFRRWDKKAGIKPNVGASGEIIRGALKIDPVRRRVTLKDNIVNISRKEFDILQLMAASPGKVFSREMILEAVWGMEWDGFERMIDSHVKRIRSKLEKNSAQPEWIETIWGIGYRFTDNYDNIVIPD
>NZ_CP043039.1|WP_000134210.1|24920_25484_-|hypothetical-protein
MTEEWNEFWLSDRNLGNLKSIYQGSYLVDIRTIDDLELETILKTELEEVKFDECEDQVGSLDGGIVIKSENSIIITPMCCGDIGNLREWEKILESQNNIWKQLWIGHPWIFYRRANGFIEISNYTESNLDDFNDIQVEYKLPEEEFFLELKKIREQQDEFENRIYRILDKMKINKAKEISKLLTGNQ

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Crispr_ID: NZ_CP043039_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043039_2

228705-228796

Orphan

Consensus_repeat	Method
AAATTTTTAAACATTCATTTTTTATG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043039_2

>merge|NZ_CP043039|2|228705-228796|CRISPRCasFinder
AAATTTTTAAACATTCATTTTTTATGATTAGAGTTCGGGTGGTTCTCACAAATTAAGTCACATTACAAATTTTTAAACATTTATTTTTTATG

>NZ_CP043039|2|1|228705-228796|CRISPRCasFinder
AAATTTTTAAACATTCATTTTTTATG	ATTAGAGTTCGGGTGGTTCTCACAAATTAAGTCACATTAC
AAATTTTTAAACATTTATTTTTTATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043039.1\|WP_080010724.1\|218516_218708_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_000444125.1\|232281_232674_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|133478
NZ_CP043039.1\|WP_000449683.1\|237831_239964_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|238657
NZ_CP043039.1\|WP_000029425.1\|224441_224975_+\|adenine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235028
NZ_CP043039.1\|WP_000125236.1\|225012_226527_+\|serine-protease	unknown	unknown	gnl\|CDD\|223343
NZ_CP043039.1\|WP_000050531.1\|234358_235036_+\|biliverdin-producing-heme-oxygenase	unknown	unknown	gnl\|CDD\|350856
NZ_CP043039.1\|WP_000612019.1\|235010_236219_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340883
NZ_CP043039.1\|WP_002187609.1\|215889_218013_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_000599987.1\|229478_230711_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_000264281.1\|223033_223921_+\|protease-HtpX	unknown	unknown	gnl\|CDD\|235478
NZ_CP043039.1\|WP_000360826.1\|220514_220985_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_025177643.1\|218018_218591_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_000353647.1\|236407_236938_-\|DUF1564-domain-containing-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP043039.1\|WP_001083733.1\|230707_232285_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_148636647.1\|220981_222592_+\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP043039.1\|WP_000614776.1\|241718_242444_+\|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|380193
NZ_CP043039.1\|WP_001079022.1\|239942_240644_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379448
NZ_CP043039.1\|WP_000944572.1\|226541_228125_+\|PDZ-domain-containing-protein	unknown	unknown	gnl\|CDD\|375351
NZ_CP043039.1\|WP_001226845.1\|240668_241247_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043039.1\|WP_000457972.1\|218632_220522_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011

Protein	Function_ID	Function_description	E-value
NZ_CP043039.1\|WP_000353647.1\|236407_236938_-\|DUF1564-domain-containing-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	1.5922e-91
NZ_CP043039.1\|WP_000444125.1\|232281_232674_-\|transcriptional-repressor	gnl\|CDD\|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	1.56858e-35
NZ_CP043039.1\|WP_000029425.1\|224441_224975_+\|adenine-phosphoribosyltransferase	gnl\|CDD\|235028	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional.	1.64186e-94
NZ_CP043039.1\|WP_000125236.1\|225012_226527_+\|serine-protease	gnl\|CDD\|223343	COG0265, DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones].	3.27595e-31
NZ_CP043039.1\|WP_000449683.1\|237831_239964_-\|TonB-dependent-receptor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	2.83339e-73
NZ_CP043039.1\|WP_000050531.1\|234358_235036_+\|biliverdin-producing-heme-oxygenase	gnl\|CDD\|350856	cd19165, HemeO, heme oxygenase in eukaryotes and some bacteria. This subfamily contains heme oxygenase (HO, EC 1.14.14.18) found in eukaryotes as well as some proteobacteria, including cyanobacteria. Heme oxygenase (HO) catalyzes the rate limiting step in the degradation of heme to biliverdin in a multi-step reaction. HO is essential for recycling of iron from heme which is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. In vertebrates, HO plays a role in heme homeostasis and oxidative stress response, and cellular signaling in mammals that include isoforms HO-1, HO-2 and HO-3. HO-1 is ubiquitously expressed after induction while HO-2 expression is constitutive, mostly limited to certain organs, such as the brain, testes, and the vascular system. HO-3 is non-functional in humans, suggesting that the Hmox3 gene is a pseudogene derived from HO-2 transcripts. In higher plants and cyanobacteria, heme oxygenase is required for the synthesis of light-harvesting pigments, which contain tetrapyrrols derived from biliverdin. Candida albicans expresses a heme oxygenase that is required for the utilization of heme as a nutritional iron source, whereas Saccharomyces cerevisiae responds to iron deprivation by increasing Hmx1p transcription, which is controlled by the major iron-dependent transcription factor, Aft1p, and promotes both the re-utilization of heme iron and the regulation of heme-dependent transcription during periods of iron scarcity. In pathogenic bacteria, HO is part of a pathway for iron acquisition from host heme. In Leptospira interrogans, a pathogenic spirochete that causes leptospirosis, HO is required for iron utilization when hemoglobin is the sole iron source, thus making HO an interesting target for novel antimicrobial agents. HO shares tertiary structure similarity to methane monooxygenase (EC 1.14.13.25), ribonucleotide reductase (EC 1.17.4.1) and thiaminase II (EC 3.5.99.2), but shares little sequence homology.	8.06116e-83
NZ_CP043039.1\|WP_000264281.1\|223033_223921_+\|protease-HtpX	gnl\|CDD\|235478	PRK05457, PRK05457, protease HtpX.	6.87179e-158
NZ_CP043039.1\|WP_000944572.1\|226541_228125_+\|PDZ-domain-containing-protein	gnl\|CDD\|375351	pfam17815, PDZ_3, PDZ domain. This entry contains the second PDZ domain from plant peptidases such as Deg2. This domain is involved in cage assembly.	5.07907e-28
NZ_CP043039.1\|WP_148636647.1\|220981_222592_+\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	2.87143e-18
NZ_CP043039.1\|WP_000614776.1\|241718_242444_+\|leucine-rich-repeat-domain-containing-protein	gnl\|CDD\|380193	NF033189, internalin_A, class 1 internalin InlA. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface or secreted proteins with an N-terminal signal peptide, leucine-rich repeats, and usually a C-terminal LPXTG processing and cell surface anchoring site. See PMID:17764999 for a general discussion of internalins. Members of this family are internalin A (InlA), a class 1 (LPXTG-type) internalin.	4.53434e-16
NZ_CP043039.1\|WP_001079022.1\|239942_240644_-\|hypothetical-protein	gnl\|CDD\|379448	pfam14064, HmuY, HmuY protein. HmuY is a novel heme-binding protein that recruits heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 278 amino acids in length.	2.99224e-23
NZ_CP043039.1\|WP_000612019.1\|235010_236219_+\|MFS-transporter	gnl\|CDD\|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.77522e-32
NZ_CP043039.1\|WP_000457972.1\|218632_220522_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0

>NZ_CP043039.1|WP_000944572.1|226541_228125_+|PDZ-domain-containing-protein
MLRIWIITILVCFSFEVLAEISSKRESNRILIKKNLSKAKEVDPDKKKEFLSTKESSILSTQGTYHKSIVQIKVTFQEPEYHQPWKKKNPRVRRGVGIVTEENQILIPYSLLPNATLIEVKKYSSYSEIKATAFRMDPESNLALLLVEKKDFFQDLVPLKFSPIVVFPKQTNVYQLDNSGSIQTTSVSLLSMDMDQMPLGQVELPVVDVSSSEGLNGFGEVVIENGKVSGILYEFTSGKNSGRMIPSFIIQKFLTTSGPDVFGYKGFRFRPMTDGSVKKYYGMEKSDSGILVADVIPGSSASGVLKLEDIILEFGGKNVDSKGYIEHPLYGKQVLSFLAHTGDLFGYSLGKEIPILVLRNKQKIRLSMKLKPFPYSAVRIPFKNIPTSNDFAVEGGFVFLELSEALLEEWGKDWRSRVDRKLLYLYDYYKFHEKEDGVGKIVLLSQVLPDESNNGFHDLSFKIVEKIDGQNVKSVRDLRQIIKHGKLEYALISLDDGTEIALNRKELPEINERIYKSYKIRFSENGH
>NZ_CP043039.1|WP_000125236.1|225012_226527_+|serine-protease
MTAILSFSFRIWNKIFFKKANRFFSLGFILFIQSGIYAVENPLPFDELRKGVVQIRVYSQAVNPFTPWTTDAVRAGSGTGFLIGNKRILTNAHVVSNAKFVQVQRYNQTEWYGVKILHLAHDCDLAVLEAENPEFYKDSRDLQLGEIPELNSPLIVVGYPIGGNKVSVTRGIVSRKDQSVYSHSAVDSHLVLQVDAAINPGNSGGPAIQDDKVVGVAFQVATKGENIGYLIPTNVIRHFLKDIEDGKYDGYVELGVRTLNSFNVFLRKAKGIPDHLEGVFVSKVLKNGSAENHLKEGDFLLEIDGQPIGKNGTVMQDKDARVDFVEIVDNKHAGDKISFKLYREGKEISVSFPARRMSDFDFMRNQYDRSYDFEMIGGLLFQEMSRDLITSWGRSGNTSGGSQLLYRFFYFIEDGLNRTKKTDVVLYRKLSHPVNSSSDYFVNMILESVNGIPVGELKDLKKILKESKDKYLRLKFLDIQVPLILNREEAEKADEKIRKIYGLE
>NZ_CP043039.1|WP_000029425.1|224441_224975_+|adenine-phosphoribosyltransferase
MSIVKSKIRTIPDYPKPGILFRDITSLLLDPEGLALTIGTFVNRYQGKGITKVAGIEARGFLTGAPLAFQLGVGFIPIRKKGKLPSETVSEEYDLEYGKDVIEVHKDSIQPGDKILLMDDLIATGGTMIAAVKLLKKLGAEIYEAGVIIDLPDLGGRKKLQEELKVPVFSICEFEGH
>NZ_CP043039.1|WP_000264281.1|223033_223921_+|protease-HtpX
MWFKRIGLFLLTNILVVVTISIVTSVLGIGPYLDANGINLSSLLVFCFLWGMGGAFVSLLLSKFMAKMMMGVQVIDPRSASGAERELYSRVERLARTANLPMPEVGIYHSPEVNAFATGPSKSSSLVAVSSGLLQTMDNAEVEGVLAHELAHVANGDMVTMTLIQGVVNAFVMFFSRIISYALSTMVKDELQYTVRLIANIVLSILFSILGSIIVAYFSRTREYRADAGGAKLAGRQNMIAALEKLKRTFDAPEDERGREALATMKISGHNKWMALFSTHPPLEARIAALKNSGY
>NZ_CP043039.1|WP_148636647.1|220981_222592_+|NCS2-family-permease
MNQNQFKWFMPGDLDGFFGLMIDNLIQILVLSFLLTTLCGVPGDFIYKVILPGTAISLLLGNLFYSWQAYRLGKKENRSDVTALPYGINTVSLFAFVFFIILPVYKKTGDYKTAWQVGLVASFLSGLIEIFGSFIAEKIRKVTPRAALLSSLAGIAITFISMDFLVRTFQNPLIAFLPFGVILLQYLARVVFPFRLPGGLVSVVLGTILAWCSGIWGNPIMDAALLKGSASQIGFYLPILSIGDLYSALGLTDIWEYLSVIIPMGIFNVIGSLQNIESAEACGDSFNTRDSLLANGVGTIVGSFFGSPFPTTIYIGHPGWKALGARAGYSTLNGIFMTLVALFGLLAFIQALIPVEAGMAIVLWIGIVIGSQAFEATPSRHAPAVVIGTLPALAGWGVLLIQSTFNYADRSIAGILENAGVKETSHLWMSDVPLSLPFLPYPMGGLLSLSQGFLISSMIWASIAVFVIDRDFKKALITCLIAAVLAGTGFIHGFTLRGNDILNQFGSSFNSFVTAYFLLGILFLLASFFRKEPRKV
>NZ_CP043039.1|WP_000360826.1|220514_220985_+|hypothetical-protein
MDKQNLKEEILTLRKFKRSLFELYWEKFGTFYLHALPHPQLVIGKRGLVGDEREVGIVLVFGSKGGVKNLDPVEEWIYAELQFGYTWEEVFIPWDCILRYFDKTQTALTNMRVFTKEQEIFKELSSGEKTVSKKKKDEEGDSSKVIQVNFGSKSKQ
>NZ_CP043039.1|WP_000457972.1|218632_220522_+|polysaccharide-biosynthesis-protein
MFAQWNRRMWIFPLDLIFMGISYFLAHWIRFESFIFLASPERFFISLAIVISVRSIVFILSDIYRSIWVYASIHDLVEIIKVTLLSSLISTTALLFYNRFEQLSRMVPVLDTLLLLSFLCIRSFSWRVFRDQYILKKSKEEGLPTLILGAGKVGATLLSEIRRHNELKLNPVGFLDDNVQKIGAHIQGIPILAKIDQAEQIINRFGVKQVIIAMSSPDGKLISRLIRSFEHTDVKFKILPSLGSLFFDSPKLNQLREVQVEDLLGRPVVDLEIESIRSYLKGKSILVSGAGGSIGSELCRQVAVFEPSRILLLDSAETPLYEIEYELGKKLQGQNIELVPIVADIKNLSRISSIFEKHSPEVVFHSAAYKHVPMMEINPTEAVMNNVLGTKNIADISRISGVERFVLISTDKAVNPVNIMGASKRAAELYLQHISRETRTKFITVRFGNVLGSNGSVIPRFREQIANGGPVTVTHPDVIRYFMTIPEATQLVLQAGSMGECGEIFILEMGEPVKILNLAEEMIRLCGLRPHVDIPIQFTGLRPGEKLFEELLLGLEGIKKTHHPKIKIAAPLENQEATTFVARFNELLTLARANKDREIFLAFKALVPEYKIHGDYLNETNANQNLQNG
>NZ_CP043039.1|WP_080010724.1|218516_218708_+|hypothetical-protein
MGVRQEKNFCNTFFDSFKNRNKPFQKDWTFKNKRILFPTCSLSGIEECGSSLWISSSWGSLIF
>NZ_CP043039.1|WP_025177643.1|218018_218591_-|hypothetical-protein
MKWLIPIFKRIEKCVAEILFLPHSNSRINRFLYWDNLKEIIINLQGDLDFKLGEVILSKLEELSEAPRRVLLDASGLESATLEGTSILNQLPERFPNSKFAICSVPTGIEISVKGENKISVFSDRDSAKLHLTANSKGKVSSFVENVLVHCPVCFHLLKIRISGNYGCPVCHSRFFVTKDWRTSAFERLL
>NZ_CP043039.1|WP_002187609.1|215889_218013_+|hypothetical-protein
MFFLAQARPVLIWPEFSWIPVINGTIFVALVLLTGYYLEKRFRNSIERRAALRAKILKKLPLTYMHGRDVVQIHSFLDHVGVSVLQKIAESSSWFQEVFLPELAIYLAHQGELPAWRDAIIFKKLQHLVHDLGPHPKKILPVVFLTDDEEAFPGLLYSGPPGSDFVQKSIHAKVFTKKLYHSFPVSTGDKIHVLYSGEDRDWIRFDAKIYSLNGNDIGIQVETAPEKDPEKTRAWGGIQMGGGILEDSTLPDEFQGSLSQILNYGSIGTSGTSEIQRRVQAFKEHPGLVRKEHKPEEIQTFIELYSACYARYRSDISPVPKPVLLFLYFFYMDENLLSPTRIVQLYETLEKIKDTQDPYPSDHKLAVYFLPEWLGLILSGKKTPSRNHLAQSYEQVRASMIRKTGTDEYAGDSGIEDLLHLLDWELSNLLFNGLIGVSANPNLAYPILSEDQMYGETDAFLVTREKINSVVDHVHKIDKHLFYRQISFEPEQTPGKPELAMKEICPDCIILPVFGSRGVLWQEITSGLSSRGRLVFPQILNENMTLAITRTLGEFRWEMERTVRGRKWKDSSPPSLTSEYYLYLENYRKSPALTPDAKKGIDQQLLKYRKNLKDMFASDYSYWILFESSGKLRLNRVARDILNRYVPFSPQLRTELQKHPILKESMDSFEAKKRRLVSGIKKRYNPYFQAGNVPVEVLETIRFFEEM
>NZ_CP043039.1|WP_000599987.1|229478_230711_-|hypothetical-protein
MILFFSKVRTFFENPFWILPLFITLYALCSLLIWKKYHWNPSSQINFGKQFAVQNIEETPKGAVIFLGRPGDLGAGYDGQIFYYYSRMLTGFHLNWPKGFEENIRAPRIGYPLLVAAFGWFGAWGTIFGMYFLNLFLILFSWFLVRDLCGVKYRIYSSFYLFSPFLLGSYTLLVSDAVLTGLLVITFWFYKKEKWIWFSLFGGLSILTKEQAFFLLFPLGVQSLLEKKWKDSILIVSTLLLPFLWAVFLRIQFPSWSPTRFTDFFTPLDGFVGYWNEINEPSLLSFLQVPNLKTSLVLFAKKFSRLPLFLLFLAGLFVFCSGNWKKGIAGRLSFFLVIFSVFSAGYVLYWSSYENVSRMFTVSIAFLIFWKLEDDSVVDLLYWIITGSIFLIFLFKLAFVSSILPYEIWK
>NZ_CP043039.1|WP_001083733.1|230707_232285_-|hypothetical-protein
MNSETRIKIKIIWIFLFLLLGFLFLDRVLFPIALFEFPNELEWDTSPWYNFLHKRKNIHFEKDEKGILITGSSVALYSSYPKQITEEIQNSNIKDGKKFRAEFYSHPALSPTDLYYYSDDILSKKPELVVYILNPADLQLDYIQKLESSEVRFDERTRIKDYKIRHQNRFIFPGEFLADHWRDYTKAEIFAQLTKTFILLNRFRSFLYDPWVEYIEHHTRTMRSYHYYTGSIPKEGIFLRGWTPPSFTIECELKDGKLSEDIFTQKPGVRIQVEEINSSAKHLNREPIFYDQTFSKSGWKSLFLDFKKNSSGENPQSVTLKFTVSPTTSSDEVDARIFGIPANYGIRLPQNFCKKEIKTNISYDRIHGLDDDRIETMSDEDYLKDYEKRLYFNPENEGALNRLKKIQRNKEILGNSTYFTWSEIQFLEKTISKFQANGQKWIIINSPENPIESKYYKNGNWYRGYLKFLNSYKNDTYGFYDLKDAIPDKRSFLDPHHLTFNAAKHSSSLYTNVILDFLNVSERKK
>NZ_CP043039.1|WP_000444125.1|232281_232674_-|transcriptional-repressor
MESKKTVLRNTKQKGEILKVLEMAKGPLSIKEIYELSRKNLDNLGIATVYRAVNHLMETGTIHEIHLPGESSRFEASRHHHHHFHCKQCDRVYDIEICPIPLDKSPKGFTVDTHEIILYGTCSDCNSKAR
>NZ_CP043039.1|WP_000050531.1|234358_235036_+|biliverdin-producing-heme-oxygenase
MSLATILREGTSEEHKAAESSAFIRCFMKGILEKGTYARHLEAFYYVYESMEEELERNKNNLVLKSIYFPELYRKNALLEDLQFFYGTWKPNDHQPSVATQDYVKRIRKISETQPELLAAHSYVRYLGDLSGGQILKKVAARALNLPEGKGISFYEFPMIQDINGFKQNYRTALDSLPVNDSEKQSILAESKQVFLLNQGIFSELEQDLVSAIGKETYDSVLGKG
>NZ_CP043039.1|WP_000612019.1|235010_236219_+|MFS-transporter
MIPFLEKVNSKKSAYFLPVAVFLAMLPVTMIVPVFKEIVKDRFQSGNEEVAWFLSIAMLGSFVFSPMAGFLSDSFGTRKKIIILFCGFDALLLNLLPYADTLFTLLFLRFLEGGAHVFVIGLLLASVADFEHVDSKRKFGNGILMGLSGMLLSLGGAVGLSFGFLGKLNPVLPFQVGSVILLFLGWIVYQFVPEEKFRVSKKHSWKESLILFLTHPLLLFPLAFQFLDRFTSGYFMSSLNLRLREEFSLNPSETGKMLSLVFLPMALLSYPAIHLSKKTGKYFPVAIGSLIYGVSLILSGIFQSVVWIGISLLFCGLGAGLMFATSLRLASSLCTRENNGIVMASLTGFGSLGFFLGPISSVGLDRISTPFIGSSSTAFVFGTAQILIVLVSIPFYKILNEK
>NZ_CP043039.1|WP_000353647.1|236407_236938_-|DUF1564-domain-containing-protein
MDILLLDDGQKIESALVESSVGTDSLLVPDVYWNRLNAQEKKALRGKLPFLLRKYSKQIASMKRLHDRAGKIKYNRGVGKMKKFSIRVHTGIWATLGVLAAAHGVSRCYLFNYMLWLEDLGGKEDFFVKSLNPGVPSFHWTYKMIWKINRRQNLISRELQFEPNPMTNKYPYDLTS
>NZ_CP043039.1|WP_000449683.1|237831_239964_-|TonB-dependent-receptor
METNPILNQLNMFSSFRRFFSSNWIQILFLFLFYVSIQAQDENIKTENKVIQKESPNTTTTDSKKDNGNGQNGQIVPEESQIVVTGSRGERRLKDSTVATEVISRKKIEASGARNAAEVLETQLGIDVVPFFGGSRVRMLGLDSQYVLILIDGERISGRLNNAVDLSRFKVQNIERIEIVKGASSALYGADAIGGVINLITREADKKLSYEMRTTYGNGSRKNFNTEGEFNTTANMGFRNEYVSGAVSAGYNKNPGYRLVPNSQATTGNAYQDLNTGINLTFNPDGKFKGKTRILYQHRDQNGVDVTQSKAVFDRNNKTHDFLATGSLEYGFGKRNLISFRGNISKWENKYYNNQRGSDELDVKQLNSELTSQGTVQLDMEASEKHFITVGAESFANELESDRLQSRYVYRTRKAVFFQDEWTVSRSPRIRVVPGVRYDDDSQFGNQTTPKLAARYDIFQNLVWRASYGRGFRPPSFQELYLRFENPAVGYVVEGNPNLKPERSITINSDLEYSPFSFLTFSLSVYRNDIINLIQYKFDSNKGREFAEFQLQNIAKAYTRGGEFGVQYRFLKYFTLELGYNHTDTRDLSSDRPLEGRALHQASANFIYNSPGGFQFNLRGKHLDKRPFYSSTNNLSAAGQDYIPSEVKLNENPPVIYGKPFTILNVRIEQKFFNKHFALFLGVDNLLNQYELAYNPTRPRFYYGGFSAQF
>NZ_CP043039.1|WP_001079022.1|239942_240644_-|hypothetical-protein
MNRFPILKQFLKHTCFWFGIFVLFQCARQHPAVDQNEVAFQQALLDLQKQIEESTRSKIISTEPNGDGSFTTRIRSVSYDVWIKYNFADKSQAFVPDMSGGWDVGFQRFKLQTNSGLTHSEGQGGACMTNPVVTDFETAASSTSTALGCVNASFSPDTNVSELASGGIQTNYVGNDVLNKWFNYSLAFLQPNYKVFVIRSNTGNEYYLFQITGYYNSEGTSAHPTIRWKQIQY
>NZ_CP043039.1|WP_001226845.1|240668_241247_-|hypothetical-protein
MRKIQKCINTTVIFSLIFSVFLNCKDDKKDDIDPLLILVGLASGSPSYNCSATVKGKVASLPAMTATTSIQTLVYGKVPFVNHSIAAVKVTGAVNGTRIVFTGRNVADFDEGTSSNENAPLIYNTSSCPLADSSQDTTRSTYTTSSEGQYGSAAGDGPYTYTLNATKGGDYYFVFYLASRTAEPPTTTFQLQ
>NZ_CP043039.1|WP_000614776.1|241718_242444_+|leucine-rich-repeat-domain-containing-protein
MIQIRFFTLLKILIFCSWIFSCSLFKKESIPGQIPVFSKEGKILRYYPYQIRWIGFNESEFPDTTRLVDFRNLVSLEILHPEFQNLEELSSLKTIGFLNINGTKVKELSPLSKLTNLHSLYLGETSVDEKDLKQYSEIGKLTKLGLYKTKIKDLSFIGSECRLQQLDIRNTEISSLEPISNCKNLLELRIGHTKIREIHPVYEMNHLRYLEWSELNLSKEELDQIRKRLPYLKLVPIHPGL

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP043039_1	1.1\|11335\|46\|NZ_CP043039\|PILER-CR	11335-11380	46	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	254712-254757	0	1.0
NZ_CP043039_1	1.2\|11397\|31\|NZ_CP043039\|PILER-CR	11397-11427	31	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	254774-254804	0	1.0
NZ_CP043039_1	1.3\|11444\|50\|NZ_CP043039\|PILER-CR	11444-11493	50	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	254821-254870	0	1.0
NZ_CP043039_2	2.1\|228731\|40\|NZ_CP043039\|CRISPRCasFinder	228731-228770	40	NZ_CP020413	Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence	120089-120128	0	1.0
NZ_CP043039_1	1.2\|11397\|31\|NZ_CP043039\|PILER-CR	11397-11427	31	MT724048	Staphylococcus phage SAP3, partial genome	34109-34139	8	0.742
NZ_CP043039_1	1.2\|11397\|31\|NZ_CP043039\|PILER-CR	11397-11427	31	CP024685	Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence	76023-76053	8	0.742
NZ_CP043039_1	1.2\|11397\|31\|NZ_CP043039\|PILER-CR	11397-11427	31	MG720309	Vibrio phage Ares1, complete genome	66318-66348	8	0.742
NZ_CP043039_1	1.2\|11397\|31\|NZ_CP043039\|PILER-CR	11397-11427	31	AY855346	Clostridium difficile bacteriophage phi CD119, complete genome	3225-3255	9	0.71
NZ_CP043039_1	1.2\|11397\|31\|NZ_CP043039\|PILER-CR	11397-11427	31	NC_007917	Clostridium phage phi CD119, complete genome	3225-3255	9	0.71
NZ_CP043039_1	1.2\|11397\|31\|NZ_CP043039\|PILER-CR	11397-11427	31	NC_028996	Clostridium phage phiCDHM19, complete genome	3472-3502	9	0.71

1. spacer 1.1|11335|46|NZ_CP043039|PILER-CR matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

taaccaaaagcctctgataatagatagggatctattttaagagact	CRISPR spacer
taaccaaaagcctctgataatagatagggatctattttaagagact	Protospacer
**********************************************

2. spacer 1.2|11397|31|NZ_CP043039|PILER-CR matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

ccacaaatttatgttgtacagttatatttta	CRISPR spacer
ccacaaatttatgttgtacagttatatttta	Protospacer
*******************************

3. spacer 1.3|11444|50|NZ_CP043039|PILER-CR matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

atacaaagctcaatcacgaaaaatgaacgtttaaaatccgtaatgtgact	CRISPR spacer
atacaaagctcaatcacgaaaaatgaacgtttaaaatccgtaatgtgact	Protospacer
**************************************************

4. spacer 2.1|228731|40|NZ_CP043039|CRISPRCasFinder matches to NZ_CP020413 (Leptospira interrogans serovar Copenhageni strain FDAARGOS_203 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

attagagttcgggtggttctcacaaattaagtcacattac	CRISPR spacer
attagagttcgggtggttctcacaaattaagtcacattac	Protospacer
****************************************

5. spacer 1.2|11397|31|NZ_CP043039|PILER-CR matches to MT724048 (Staphylococcus phage SAP3, partial genome) position: , mismatch: 8, identity: 0.742

ccacaaatttatgttgtacagttatatttta	CRISPR spacer
attcaaatttatcttctacagttatatgatt	Protospacer
 . ********* ** ***********  *

6. spacer 1.2|11397|31|NZ_CP043039|PILER-CR matches to CP024685 (Bacillus wiedmannii bv. thuringiensis strain FCC41 plasmid pFCC41-1-490K, complete sequence) position: , mismatch: 8, identity: 0.742

ccacaaatttatgttgtacagttatatttta	CRISPR spacer
attccaatttatgttgtttagttatattatt	Protospacer
 . * ************ .********* *

7. spacer 1.2|11397|31|NZ_CP043039|PILER-CR matches to MG720309 (Vibrio phage Ares1, complete genome) position: , mismatch: 8, identity: 0.742

ccacaaatttatgttgtacagttatatttta	CRISPR spacer
acctagttttattttgtactgttatattttc	Protospacer
 * .*. ***** ****** **********

8. spacer 1.2|11397|31|NZ_CP043039|PILER-CR matches to AY855346 (Clostridium difficile bacteriophage phi CD119, complete genome) position: , mismatch: 9, identity: 0.71

ccacaaatttatgttgtacagttatatttta	CRISPR spacer
aattaaatctatgttgtactgttatatgctc	Protospacer
   .****.********** ******* .*

9. spacer 1.2|11397|31|NZ_CP043039|PILER-CR matches to NC_007917 (Clostridium phage phi CD119, complete genome) position: , mismatch: 9, identity: 0.71

ccacaaatttatgttgtacagttatatttta	CRISPR spacer
aattaaatctatgttgtactgttatatgctc	Protospacer
   .****.********** ******* .*

10. spacer 1.2|11397|31|NZ_CP043039|PILER-CR matches to NC_028996 (Clostridium phage phiCDHM19, complete genome) position: , mismatch: 9, identity: 0.71

ccacaaatttatgttgtacagttatatttta	CRISPR spacer
aattaaatctatgttgtactgttatatgctc	Protospacer
   .****.********** ******* .*

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP043041

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP043041_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_1

1259548-1259650

Orphan

Consensus_repeat	Method
CTCTTAGAACGATCAAGATTTTGATATGAAATTAAAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043041_1

>merge|NZ_CP043041|1|1259548-1259650|CRISPRCasFinder
CTCTTAGAACGATCAAGATTTTGATATGAAATTAAAAAATGCAGTAGTTCCCACAGAATTACGTCTCTTAAAACGATCAAGATTTTGATATGAAATTAAAAAA

>NZ_CP043041|1|1|1259548-1259650|CRISPRCasFinder
CTCTTAGAACGATCAAGATTTTGATATGAAATTAAAAAA	TGCAGTAGTTCCCACAGAATTACGT
CTCTTAAAACGATCAAGATTTTGATATGAAATTAAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_148636724.1\|1266670_1266997_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|376903
NZ_CP043041.1\|WP_000833715.1\|1267750_1269679_+\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP043041.1\|WP_000421041.1\|1251243_1252263_+\|4-phosphoerythronate-dehydrogenase	unknown	unknown	gnl\|CDD\|240635
NZ_CP043041.1\|WP_000876121.1\|1258053_1258296_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000079210.1\|1253599_1254502_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275263
NZ_CP043041.1\|WP_000433680.1\|1265604_1266615_+\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
NZ_CP043041.1\|WP_002097444.1\|1254479_1255166_-\|DNA-alkylation-repair-enzyme	unknown	unknown	gnl\|CDD\|132880
NZ_CP043041.1\|WP_002187436.1\|1250122_1251157_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377013
NZ_CP043041.1\|WP_000508810.1\|1260026_1261196_+\|DUF1577-domain-containing-protein	unknown	unknown	gnl\|CDD\|369443
NZ_CP043041.1\|WP_000723997.1\|1266993_1267740_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275213
NZ_CP043041.1\|WP_000459252.1\|1269683_1270622_+\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP043041.1\|WP_001045091.1\|1264883_1265630_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl\|CDD\|273139
NZ_CP043041.1\|WP_000365021.1\|1255338_1257039_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
NZ_CP043041.1\|WP_000358329.1\|1263573_1264887_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	unknown	unknown	gnl\|CDD\|223694
NZ_CP043041.1\|WP_002187371.1\|1249958_1250111_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001072287.1\|1262449_1263565_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379173
NZ_CP043041.1\|WP_000493049.1\|1257209_1257875_-\|protein-L-isoaspartate-O-methyltransferase	unknown	unknown	gnl\|CDD\|178974
NZ_CP043041.1\|WP_000196651.1\|1261654_1262428_+\|outer-membrane-lipoprotein-carrier-protein-LolA	unknown	unknown	gnl\|CDD\|319983
NZ_CP043041.1\|WP_002108990.1\|1248385_1249933_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP043041.1\|WP_001001361.1\|1258395_1258827_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379324

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000833715.1\|1267750_1269679_+\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	2.95752e-150
NZ_CP043041.1\|WP_001072287.1\|1262449_1263565_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379173	pfam13413, HTH_25, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.16019e-20
NZ_CP043041.1\|WP_148636724.1\|1266670_1266997_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|376903	pfam02699, YajC, Preprotein translocase subunit. See.	1.05942e-26
NZ_CP043041.1\|WP_000079210.1\|1253599_1254502_-\|radical-SAM-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	1.56313e-20
NZ_CP043041.1\|WP_000433680.1\|1265604_1266615_+\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	7.96128e-154
NZ_CP043041.1\|WP_002097444.1\|1254479_1255166_-\|DNA-alkylation-repair-enzyme	gnl\|CDD\|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	2.09819e-09
NZ_CP043041.1\|WP_002187436.1\|1250122_1251157_-\|hypothetical-protein	gnl\|CDD\|377013	pfam03280, Lipase_chap, Proteobacterial lipase chaperone protein.	8.69416e-08
NZ_CP043041.1\|WP_000508810.1\|1260026_1261196_+\|DUF1577-domain-containing-protein	gnl\|CDD\|369443	pfam07614, DUF1577, Protein of unknown function (DUF1577). A family of hypothetical proteins in Leptospira interrogans.	1.24948e-102
NZ_CP043041.1\|WP_000723997.1\|1266993_1267740_+\|hypothetical-protein	gnl\|CDD\|275213	TIGR04420, Sec_Non_Glob, Sec region non-globular protein. Members of this family occur only in the genus Leptospira, always encoded between genes for the YajC and SecD components of the Sec preprotein translocase. Sequences have an N-terminal signal peptide and a C-terminal transmembrane segment. Between these are regions of non-globular, low-complexity sequence including Lys-rich and Ser/Thr/Asn/Glu-rich regions.	6.82364e-87
NZ_CP043041.1\|WP_000459252.1\|1269683_1270622_+\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.44272e-88
NZ_CP043041.1\|WP_001045091.1\|1264883_1265630_+\|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl\|CDD\|273139	TIGR00560, pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis].	4.27529e-35
NZ_CP043041.1\|WP_000365021.1\|1255338_1257039_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	8.20482e-42
NZ_CP043041.1\|WP_000358329.1\|1263573_1264887_+\|30S-ribosomal-protein-S12-methylthiotransferase-RimO	gnl\|CDD\|223694	COG0621, MiaB, 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis].	1.1642e-119
NZ_CP043041.1\|WP_000421041.1\|1251243_1252263_+\|4-phosphoerythronate-dehydrogenase	gnl\|CDD\|240635	cd12158, ErythrP_dh, D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains. D-Erythronate-4-phosphate Dehydrogenase (E. coli gene PdxB), a D-specific 2-hydroxyacid dehydrogenase family member, catalyzes the NAD-dependent oxidation of erythronate-4-phosphate, which is followed by transamination to form 4-hydroxy-L-threonine-4-phosphate within the de novo biosynthesis pathway of vitamin B6. D-Erythronate-4-phosphate dehydrogenase has the common architecture shared with D-isomer specific 2-hydroxyacid dehydrogenases but contains an additional C-terminal dimerization domain in addition to an NAD-binding domain and the "lid" domain. The lid domain corresponds to the catalytic domain of phosphoglycerate dehydrogenase and other proteins of the D-isomer specific 2-hydroxyacid dehydrogenase family, which include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	8.91783e-107
NZ_CP043041.1\|WP_000493049.1\|1257209_1257875_-\|protein-L-isoaspartate-O-methyltransferase	gnl\|CDD\|178974	PRK00312, pcm, protein-L-isoaspartate(D-aspartate) O-methyltransferase.	2.53546e-55
NZ_CP043041.1\|WP_000196651.1\|1261654_1262428_+\|outer-membrane-lipoprotein-carrier-protein-LolA	gnl\|CDD\|319983	cd16325, LolA, LolA, a periplasmic chaperone. This family contains periplasmic molecular chaperone LolA which binds to outer-membrane specific lipoproteins and transports them from inner membrane to outer membrane (OM) through LolB, a lipoprotein anchored to outer membranes. There are five Lol proteins (LolA, LolB, LolC, LolD, and LolE) involved in the sorting and membrane localization of lipoprotein and are highly conserved in Gram-negative bacteria. LolA accepts OM-specific lipoproteins that are released from the inner membrane by the LolCDE complex and transfers them to the OM receptor LolB. Studies have shown that hydrophobic surface patches large enough to accommodate acyl chains of the OM lipoproteins and the structural flexibility of LolA are important factors for its role as a periplasmic chaperone.	1.73701e-24
NZ_CP043041.1\|WP_002108990.1\|1248385_1249933_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	1.1617e-56
NZ_CP043041.1\|WP_001001361.1\|1258395_1258827_+\|ATP-binding-protein	gnl\|CDD\|379324	pfam13671, AAA_33, AAA domain. This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	1.41408e-13

>NZ_CP043041.1|WP_001001361.1|1258395_1258827_+|ATP-binding-protein
MNEEKSLILLRGLPGAGKSRLAKLLSENGKYPVFSVDDYFTDSKTQEYNFDYKKNHLAYKHCEDCVRKEAERGTSKIFSDNTFTLSWEMEPYFQIASEFEYTIFVITVENYHNGKNVHSIDDESLKKMASKYKIRLLPEILSE
>NZ_CP043041.1|WP_000876121.1|1258053_1258296_-|hypothetical-protein
MKYLETEQIIPSKGMSYTMYEVEGEDQIQKMMTYIPNTDEIHIYPKPPVKKLYKPELCKVIDEVVFSELWKLGEERKAAK
>NZ_CP043041.1|WP_000493049.1|1257209_1257875_-|protein-L-isoaspartate-O-methyltransferase
MFSSSKVCNPILREQERKNMVDLQIASRGIRDKKILSAMLSIPRECFVPNSHILQAYEDKPLPIGCNQTISQPFMVAWMSLLLEVRKGDRIFEIGTGSGYQSAVLIFLEATLYSVEFFDSLSKTATQNLECWNPGCTQTNRFMIGSATEILKPELQFDKMISCAALPNLPDTKSSYFQSLIPGGIFIFPMGKRDQSLIFAKRNLNDWSFESKGGVRFVPLL
>NZ_CP043041.1|WP_000365021.1|1255338_1257039_-|acyl-CoA-dehydrogenase
MDLLNPKKTEFKHLDEKSRNIMKRTIAFFEKKGKNKLKEDDRNQTWYADFLEFQKSEKIFATLMTPSGYGENDSRWDTTRICDFNEIAGFYGLCYWYTWQVSMLGLGPIWNSKNEEIKHKTAKLLLDGEIFAFGLSEKEHGADLISSDMSLENKGNGNYIANGRKYYIGNSNKAAIVSTFGKMKDTGNYVFFAVNSGHKNYELIQNVVNSQSYVGEYALKDYPISEKEILSKDREAWDASLSTIAVCKYNLGWASIGICTHSFYEALNHASKRKLFNRNVTDFSQIKQMFVDAYCRLFSMKLFAARAKDYMRSASATDRRYLLFNPMVKMKVTMQGEEVINLLWDVIAAKGFEKNMYFEMAAKDIRGLPKLEGTAHVNMALIIKFMNNYFFEPNSSLPVVPKIDDFKNDDFLFNQGTTSKGFEKITFRDYNEVYSNIDLPNVLIFRKQIAVLKEFLKSTPPDSKQSKDLDFMLILGELFTLVAYGQLLIENAAIEKVDNDLLDQIFDFMVRDCSKYALQLYSKRSSTKEQMEKCLAMIFKPAENEELFNRVCAKVYSYKDAYEMAP
>NZ_CP043041.1|WP_002097444.1|1254479_1255166_-|DNA-alkylation-repair-enzyme
MILSKLSDSDESLWIFIIESELLKKKIKFPLLEFVGKELYFKIPEMNQIYFTDQIIKLGHMGGYVISAIILQLRMEKHFEQSLNKAVEYILLGNEWYVCDIIGERIMGYFLLKEPEKTLPILKNYINDKNGWIVRSVGVASHYAVKKGLGKKYVEVTFYLLLSKTDTKDFHTKKGIGWALKTISKFYPDIIQKFESNLLANPSIQPFFRKKIEIGLSRSSKYGSKYSD
>NZ_CP043041.1|WP_000079210.1|1253599_1254502_-|radical-SAM-protein
MAQSIRIKNILNKTKRRDPWFLDDYTINPYSGCSFRCLYCYVKGSKYGLNVEDKLSIKENAVEILDKQLSNLAKKNRHGIIVLSSATDPYLQLEKERGLTRELLKIILKYKFPVHILTKSDLILRDLDLLSEIEKNAILPVDLQNQLSRKSFITFSFSILDDSIAKIFEPGATSPSLRISALKETLKEGFFSGVSLMPLLPHISDTGENLEFMFQTFQEIGIRYIFPASLTLFGGNDPLDHKNLIFKAIENHFPHLLSKYQKFFSKNFRMPNFYQNALYHKTSELCSKYGLQKGILTTEF
>NZ_CP043041.1|WP_000421041.1|1251243_1252263_+|4-phosphoerythronate-dehydrogenase
MELKKPILYYPEGTIGAKEIFSSFEKLEVRSYPNDRIREISRDEPTILIANTRFQVNRDNIQNFPTVKIFATVSSGTDHVDFNALKEFKKIFLNAPGCNAGSVAEYCFAGLLNRFKESELKGLKIGLVGHGHTGKEFYKILISKGVNCIFYDPFYKTESRPLSEVLDASVLSFHVPLTKDGPEPTFRFVSTSLIDSLKSGTIFINTSRGEILSREAFNRLIARNDIFKILDVFDPEPPTLEMGRKLSEVKHSILTPHVAGYSQLGRIGGTYRVAEKLSILYQDKPLPPLNFFLQTSGEFKTSTFLKEEDRLLREAWRNGDTNYFEKRRNTYPIRLDWDF
>NZ_CP043041.1|WP_002187436.1|1250122_1251157_-|hypothetical-protein
MKTLQQKITFPILVGLISVTLIMLIWFVFFSGSKITTSSSASLDPESSSGSEGWILNQAIINTSRRIFDENGNWLSFDELIQYASNGEINLISELSDLRRQCPENIHYEQCNEIIRAFIADHYFGKDAEYLMKLFSSYLKYETKMKELEISDKLSRAEKYELIKKQRREFFSDKDTKLIFGLEEAEETYLDSLGGFLKDTETLSGEQRMQKYEEFRKNVYGQYYNTIKKREPKYNTYETEMFLREKELERMSSSERNSKTRHIREKYFGKDGADRMETVYQESEEKEKKEKQTAQEESDWIRKNPNVKVEIKEKALMEIRIKNLGKEEAEEYSRRLKYEEEIKK
>NZ_CP043041.1|WP_002187371.1|1249958_1250111_+|hypothetical-protein
MREKNKKIQEIDANTPAEKNENGESPNTVPIPIPKHSISRYKIESLEMKL
>NZ_CP043041.1|WP_002108990.1|1248385_1249933_-|apolipoprotein-N-acyltransferase
MWLLILSQILNFTAFYWIPGAISRISGANTFVSILFFFLYGLISHLKFFLFYTLFRFSKIDSASKTYILLIFPAAGTLSDMITFQIFPWYWGNLISGSIVFEQFASICGVYGLSFLLLFISSTFLILVNYYKYKNSKEFKTSIASLICIAFIYGFGLYRIGYINQSQNELKPKNLSVLMIQPDTSPGTKDLKADASYLSATMSKVFSLAIPTFENSPSLIVIPESAIPFHGTIDSEENRKEKIYSSTMEGIVLYLSKHTGADVLFNELNLDENKLRNQVSLFKNLDGKTERYNKRRLLPFGEYLPMEKNFPFLRSIFQETSRYVPGEFPKLLIGNKIQNQRSFLPPEISKLNEPKTYRYEFSSIVEHTNKIRNLEYSYSILPLLCYEAMFTELVLDYFQNEQKPEVLINITNDSWFDSELEAYQHSGAVRLRAIETGLPLIRSAVSGISEVWDARGIPMIVPIGFHETGTRAFSIRLDAIESTIYTRFGNSFLWIFCILILISRLIFVSRIERKS
>NZ_CP043041.1|WP_000508810.1|1260026_1261196_+|DUF1577-domain-containing-protein
MGGIKLKERDLDVINSPEQRKHIIEKHLLNQSLRIKGDLNRETITIQRYVDSGEKIIAGISDETHFSENDEIVLYKILAKYVQLECSFIRKTRPGVAEFSVNKVSIAKSNRAFPRYSVAEDAAHVTNINSSKTVIDASLFNIPTLVKVSFEDYKTKLKPDQLGLVEIDVFRSDQDEKFELIKRTKKYIHIENTSLEESYKSKSENQVDVEDEIHEEIPSLMRKYKDEKIVSEIIYPIIYINHSRQSIPLGYIWVRNKEKTLGNNTIEKLAELSKEMVARIKESNTVLTTEKFPIIDISNNGICIKITEPHLIQTLPKHTGFVFDIYIRMQGYFKVFGAIRWLSYDEVGSLILGMELVAKSSFPGEREKFHRNVELLGQGKFTGLKTHAI
>NZ_CP043041.1|WP_000196651.1|1261654_1262428_+|outer-membrane-lipoprotein-carrier-protein-LolA
MTRFPRHLILVKKIPGDPVFLMKKTIILSFFILFLALEPSLLAQPAHNWNSPSEVVKQVKKKFSDLNSYKADFQIQTVSNKKSKNMKGVCLYKKGGRIRYQFNEPSGDEIVSDGKTLYIYIARLNAVGKQDLTLNKSNKSGPIFSNFTDEGLSRIFRKYHYKFDSIEQPQTSSKDGRKYFVLNLEQREKIGGFETMLLYVDAQTYFIQKAVASDGRGKETTIEFSNLEINPDLEDGQFNFHIGGNAKIINNPLVSEQ
>NZ_CP043041.1|WP_001072287.1|1262449_1263565_+|helix-turn-helix-domain-containing-protein
MNQKRVGQILREAREEKKLSVKDVARETNISVKYILALETEDYSQFPGETFTMGFLKNYGGYLKLDTGQLINLYRGEKIEESQAPLEELTRPTASYYTKINVDKNKIFTIASVLIILISAYLIIDSFIGPSSDEDSVEESGKKLDIPENIDFLSRSIPENRSESFILTPDKGVSFSVSNQQCKLFIDSVEKGGAVNTAVLAFNVYPELTVYKFRLSEGQEKILSYTIPEISSLRRNVRIISQAVTENSAKVLVTLSDEEQKQENNNSVDNTKTLGDVPIQVTLFFNKPSYAEFIIDGQMGFRGLVQTGETRSLEAKDRLELKVGDGSAVEMIQNGKPKITLGRPGKLVKKIFVKTQNPYDSTQSIIKELGE
>NZ_CP043041.1|WP_000358329.1|1263573_1264887_+|30S-ribosomal-protein-S12-methylthiotransferase-RimO
MDKKFYITTLGCPKNIADSMSMHHSLLEEGFTPASLPEESDFHFINTCTFIQSATEETIQTILSAAQVKKQNHQKLVVVGCFAERYPDNIHSEIPEVDLFFGTGKYSQAGKILREKFPELSPSQLEFNDSLLERWKLSSKIENYSKPYAYVKVSDGCNRGCSFCIIPSFRGKFVESPLDDILRDTNRAIRAGAKEICLVSQDTVYYGRDSEILLDMVRKVAEIDSLEILRLLYLYPDKKTEKLIRLMGETSKIAPYLESPLQHVSSKILKVMNRTGESSYFKDLFSLAREVKPGLEIRTSFIIGYPGEEPEDVDQILRFIEDTRPEKVNLFSYSPQEGTKGAQLKQTVSEKEKSKRINLIRDSHLEILEEIHESRIGRTYDAIVDGIEDGQVVVRRFQDAPEMDEVVYVDDVSLLPGRIGKVRIDSFYEYDMNGTWV
>NZ_CP043041.1|WP_001045091.1|1264883_1265630_+|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALILFSVASLTDLIDGYLARKWNQETEFGKFLDPLADKIIVTGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQAYATGKANGLTVFEFATNNAIQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTTITVISGIRYLVSNSKVLYPSNLKGMFQKNGTKSSRS
>NZ_CP043041.1|WP_000433680.1|1265604_1266615_+|anthranilate-phosphoribosyltransferase
MEPRAAVLKLIEHKHLTALEAESFMNHVMKGEVSEILLSSFLTAMRFNGESVEEVLGCTLALRKNALRPKTVFPFDLLDTCGTGGDGQGTINISTLSAIVLASLGIKVAKHGNRSVSSHTGSSDILTRLGYQTETTQEEVEAHLVNRGFTFLFAPMWHPSMKHAGPVRKELGFRTVFNMIGPLSNPFSPQFQIIGVYQPELMELFIKVLQSLGLKRALVCHSRDGLDEFSIFQITDYTFLENGVISRHSFDPKILGLSSLNKEEVYASSSDHAEVLARKVLNSESIAGTHAVALNAGAGLFVMGKIDTIEQGYQIAKEAILSGKTKKYFEDLISKE
>NZ_CP043041.1|WP_148636724.1|1266670_1266997_+|preprotein-translocase-subunit-YajC
MTFDILLRLAQAAGEGDKSPFSTLLLIPIMLVIMYFLVIRPQRNEEKKRKEMIDSLKKGDEVVTSSGIHGKVVEIKDNNEVVVLNIAKDTNVSFTASTVLKKKQQADK
>NZ_CP043041.1|WP_000723997.1|1266993_1267740_+|hypothetical-protein
MKKISILILIFLFLGNLALFSQDGEEIDFLEKVTEPKKTVSKKSSNTAGASSGTSTPKKKEKKRSKKKRSKKSSSSIPNNLEETQKKNVIPNTNETSSGNNNSNLNGSNSGSSNTLESGNVDEQRVSASKMDLRDLPKPYWVNEEVQIHPNNLPGYTVSQKSEQGSSFGSGLSEILKLGEDKKKEENKKKVQEVQKSGSFTGFISEYKKPIIIIVFILLFALYRLKAGKSRGSSSRKSPVTINKMRRD
>NZ_CP043041.1|WP_000833715.1|1267750_1269679_+|protein-translocase-subunit-SecD
MKSATWIFLPLLIILAATVILYPNFATRELELAVRKEFISISPEQKKAILSRFEERWNREYKQSDWVISPSPSELKDESFLLVKGRFITSAKINQISQENPELILEAKNKLRPTLVEEWITKGRPLTIKLGLDLQGGMRVAMKGDFEDYASKLRESYIKEIENLNKTVTDPSADEKEKKKAKDRLSEIESYFELSPSRKLLELEKAKLIIDNRLTSQNLTEPQVRIQKDQDSIEVSLPGVTNSSQILEIIQNTETVEYRLEEPENSAGNGLTYASIIQQEENRLLELKRREETDIVQYQNIIKQKLGKAEQDKFLQGLEEKYKIPRDRYRVFAYWARGNHQNSTLLPRKFVVLEKAIALDGRDMRDARPSFENNSFGYIVSFTLTSSGAEKFFEITSQNKGRNLAIVWGDKVVSAPTIRSAIAGGVAQIDGSFTKEEAVDLANVISEGALPIPLRVLEMRFIGPTLGIESIEVGMKAVLIGFVLVMFYMILIYRLSGLVANAALFANIVILSALLSLMGFTLTLPGFAGIILTVGMAVDANVIIYERIKEELRAGKSATVAVAQGFDNAFWTIIDSNVTTLISGILMIRLGNGPIKGFAITLCWGIITSLFTSLFLSRLVMDLLVNRLGVQKLQLGFKKLES
>NZ_CP043041.1|WP_000459252.1|1269683_1270622_+|protein-translocase-subunit-SecF
MFDFIKYKYVSICISLALIVFGFSYTYAVHGGFANSLDFNGGLRTVVEFDQNMDRKKLENYFAENKIEAVLLLLDKEKHHYQIDIGLGSVDSILLKYREKNGLKPTDKVELSGIDALISILIADFRIDKSNILSANQVGAIVGGELSSTGTTLLGLTMAIILAYISFRFQFKFALGAILALTHDLILTVAFIGFFQIKPSVPIIAALLTLLGYSINDTIVVFDRIRENSAGNLNQTFGQTINSAINQTLGRTFNTSFATLISIVAIIIGGATELFDFAYVLTFGIVIGTYSSIFIAAPLVDIYDQVIRKARD

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Crispr_ID: NZ_CP043041_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_2

2520057-2520156

Orphan

Consensus_repeat	Method
TTAGTGGTAGTTCTCACATTTTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043041_2

>merge|NZ_CP043041|2|2520057-2520156|CRISPRCasFinder
TTAGTGGTAGTTCTCACATTTTAGTGTAAATCTTTGACTTAGTGGTAGTTCCCACATTTTAGTGTAAATCTTTGACTTAGTGGTAGTTCCCACATTTTAG

>NZ_CP043041|2|2|2520057-2520156|CRISPRCasFinder
TTAGTGGTAGTTCTCACATTTTAG	TGTAAATCTTTGACTTAGTGGTAGTTCCCACATTTTAGTGTAAATCTTTGAC
TTAGTGGTAGTTCCCACATTTTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_000612757.1\|2512134_2514951_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP043041.1\|WP_002187457.1\|2526484_2528701_-\|leucine-rich-repeat-protein	unknown	unknown	gnl\|CDD\|215061
NZ_CP043041.1\|WP_001281423.1\|2515564_2516245_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000116243.1\|2516247_2516784_+\|peptide-deformylase	unknown	unknown	gnl\|CDD\|237227
NZ_CP043041.1\|WP_002188258.1\|2507326_2510071_-\|biotin-requiring-enzyme	unknown	unknown	gnl\|CDD\|236307
NZ_CP043041.1\|WP_002079097.1\|2506511_2506646_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_139343781.1\|2521586_2521769_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001080347.1\|2520161_2521244_-\|PepSY-domain-containing-protein	unknown	unknown	gnl\|CDD\|377164
NZ_CP043041.1\|WP_000839353.1\|2516803_2520046_+\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP043041.1\|WP_002187461.1\|2531057_2532638_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|215061
NZ_CP043041.1\|WP_001973770.1\|2510077_2511730_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	unknown	unknown	gnl\|CDD\|227136
NZ_CP043041.1\|WP_000004280.1\|2514965_2515274_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_025180781.1\|2506914_2507253_+\|YceK/YidQ-family-lipoprotein	unknown	unknown	gnl\|CDD\|227932
NZ_CP043041.1\|WP_002187452.1\|2532708_2533995_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275380
NZ_CP043041.1\|WP_002187459.1\|2530702_2530888_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183173
NZ_CP043041.1\|WP_033110667.1\|2530878_2531061_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000406879.1\|2511821_2512151_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP043041.1\|WP_100225741.1\|2525958_2526153_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000915022.1\|2529598_2530570_-\|membrane-protein	unknown	unknown	gnl\|CDD\|275130
NZ_CP043041.1\|WP_001971044.1\|2524813_2525887_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000612757.1\|2512134_2514951_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	7.32649e-56
NZ_CP043041.1\|WP_002187457.1\|2526484_2528701_-\|leucine-rich-repeat-protein	gnl\|CDD\|215061	PLN00113, PLN00113, leucine-rich repeat receptor-like protein kinase; Provisional.	3.05488e-41
NZ_CP043041.1\|WP_000116243.1\|2516247_2516784_+\|peptide-deformylase	gnl\|CDD\|237227	PRK12846, PRK12846, peptide deformylase; Reviewed.	6.93109e-80
NZ_CP043041.1\|WP_002188258.1\|2507326_2510071_-\|biotin-requiring-enzyme	gnl\|CDD\|236307	PRK08591, PRK08591, acetyl-CoA carboxylase biotin carboxylase subunit; Validated.	1.02425e-44
NZ_CP043041.1\|WP_001080347.1\|2520161_2521244_-\|PepSY-domain-containing-protein	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.95887e-51
NZ_CP043041.1\|WP_000839353.1\|2516803_2520046_+\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP043041.1\|WP_002187461.1\|2531057_2532638_-\|hypothetical-protein	gnl\|CDD\|215061	PLN00113, PLN00113, leucine-rich repeat receptor-like protein kinase; Provisional.	1.22433e-38
NZ_CP043041.1\|WP_001973770.1\|2510077_2511730_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	3.23486e-128
NZ_CP043041.1\|WP_025180781.1\|2506914_2507253_+\|YceK/YidQ-family-lipoprotein	gnl\|CDD\|227932	COG5645, COG5645, Predicted periplasmic lipoprotein [General function prediction only].	0.00172596
NZ_CP043041.1\|WP_002187452.1\|2532708_2533995_-\|hypothetical-protein	gnl\|CDD\|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	1.29771e-44
NZ_CP043041.1\|WP_002187459.1\|2530702_2530888_-\|hypothetical-protein	gnl\|CDD\|183173	PRK11519, PRK11519, tyrosine-protein kinase Wzc.	0.007784
NZ_CP043041.1\|WP_000406879.1\|2511821_2512151_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.89607e-25
NZ_CP043041.1\|WP_000915022.1\|2529598_2530570_-\|membrane-protein	gnl\|CDD\|275130	TIGR04327, hypothetical_protein_LlicsVM_10020, outer membrane protein, LA_2444/LA_4059 family. Members of this family are predicted outer membrane proteins, apparently restricted to the Leptospiraceae (Leptospira and Leptonema).	2.03606e-103
NZ_CP043041.1\|WP_001971044.1\|2524813_2525887_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP043041.1|WP_000839353.1|2516803_2520046_+|efflux-RND-transporter-permease-subunit
MKSLVEFFLSKSIFVNLLTFLVILIGGFTAVKMNREAFPNINFDIVSVVTVFPGASPSEMEKLVTKPLEEAIQEVDGIKEFRSASIENRSGIVITLDPDSKNTQKVVDDIKSAIDRVEDLPEEAEDPIVTEITTSRQPVIEINISLKSNDSSIEAEKHLKAQAKIVEQALEDIPGVARISKRGWRDTEMQVDIDPVAMFSKYLTSQDIIFALKNRNINFPGGNIAGNQKEVILRTIGEFNSPKEIETVHVRSNEVGNSIRIDNVARVTEGLKEAEYLDKVNGKKTIALTVIKREKADAILVVDEAKKIIEEFKKNSKNEFEYAFVNDLSKYIRRRLGVLLSNAIGGLILVTASLFLFLGWRVALMTALGIPVSFGATFVIMDYLGLTLNLISMFGLIIVVGILVDDAIIICENVYRYMEEGMPAYEAALKGTSEVIDPVTATVTTTVAAFAPMLFMTGIFGKFIYSIPLVVIIALLASLSEAFFILPSHLYDINKHKFHSGEIKEESGWFYKLKVNYYLPLLKFALKHRLQIFIYLFAMLVGSFALFAVFGRFKLFPGSVDVFQIKLTGQTGISLQEMEKFTHALETELAKISKEEIENYVTRVGIIQKDPNDPFTKRGKHYAQVLVYMTPEENRKRGTDTIISEIREKTIWLLNEKSVKTLEETRKKEAEKKKEEYKPFNLNEYPAEFSRFKGQLLALDFEKLAGGPPVGKPVAIEIRGDDYDTLIRIGEEYKSVMAKVPGVTDIGDDFNEGKDEIRIKVNESLASTAGVSVFKVAQAINTAFQGTVATKIKRADEEVEVKVRFPEEVRKSIGSLNNIFVSNQLGKLIPVSRLINYVREPGFANINHLDGKRLLTVTANLDEIKTDTRRANAEIAKLSKGIIDKYPGYRMRFGGENKDTEESLASLGRAFLVAFIIIFMILASLFRSLIQPVIVVSSIPFSLIGVILAFVLHGEYFGFLAFLGIVGLAGVVVNDSIVLVDFANQLKLEKPGEDIDSILVETGLLRLRPVVLTTVTTVLGLLPTAYGIGGKDPFLVPMALAFGWGLAFSSFLTLVAVPVLYKTVHNVQLKINRVFLKSKR
>NZ_CP043041.1|WP_000116243.1|2516247_2516784_+|peptide-deformylase
MSVRKILRMGDPILRKISEPVTEDEIQTKEFKKLIRDMFDTMRHAEGVGLAAPQIGILKQIVVVGSEDNERYPGTPDVPERIILNPVITPLTKDTSGFWEGCLSVPGMRGYVERPNQIRMQWMDEKGNQFDETIDGYKAIVYQHECDHLQGILYVDRLKDTKLFGFNETLDSSHNVLD
>NZ_CP043041.1|WP_001281423.1|2515564_2516245_+|hypothetical-protein
MSDLIQIRRWNIDNKNVLILIPDLESKERQLYAKNFYSHFSIREVELSTKLVRFDFPKTEEWIDRLSREILDSKRKVKLIGEGLWGGIVFELLKKYPQMIEAACILNPPLNRKEENWFPKNVEWILERFPWNLFSEGIYTFYQTLETKLQFGLTNSKLLPTIVFTKTPEKITKQIQTLQKFPVFRIESSNLKSIHELLENLILKILTEVPISSVQKKSKFKIDPGF
>NZ_CP043041.1|WP_000004280.1|2514965_2515274_-|hypothetical-protein
MSESIEDLQKKLKIQNDIIKGYEKVLRLNEQELENADEIIRMYEGIIQYSGKELKDVKEAFDATNVVTNLSREELMSALSRIKELENVNKKLREEALKFQTG
>NZ_CP043041.1|WP_000612757.1|2512134_2514951_-|SpoIIE-family-protein-phosphatase
MIPNKKQDSLLRQGSDGSLYLEDNPGLTVVFESLLTEIIHITSAKFGIFSFRLEDGTLKSIYGNHPSNKIEEAKLVSEFCFKTGQDLNLKKGESPNKLIPQLEQNSVCCVLHVGELGDSSLEDQKKIFGTILLGRSDQEGGEFRESDFIHLKATVRIISDLLEKSFISGESSLVVLSLMTISRVALESVQIRKQTDRFDFLLTEIIRVSGLINKSLDLSQLLEAIMLSSKSVFRTEACSVLLLDDTKEYLYFHTVLGEKRDEVTKVKVPVGKGIAGMVVQDKKPMIINDAMNDPRVYREVDKASHFVTRNIMAAPLLVEGQVIGVIETINTIDRNSFTEEDLELFLSFSGTSALAIQKTGLLQNLEDANKDLRKKVSELESLFELSQVVSSAKSQADLMKHSIPVIHNEMDAGRTGIFLINRRMGLLTCISYTSEKIVEIFRTKDYQGSFIYRSVEEEKTTIKEDIQNFEFNHELDLEFLKGSYIVLPLTNPERNAFGVITVSDRVDKLSYNYSHLRLLQTFASLIARGHETLKLQNEMISRKAMQRSLEREIEITREIQKNILPESKVFHSNFDLGVKSVPAKEVSGDFYDYYQYQDGQYSFLISDVSGKSLPAAIFMAMSSSIIRTLARDHDLDPEEILKQGNALIYEDSHNGMFVTTFFIHYNPAIFTLDYASAGHNDQVLIRKDDSWEIIKGSGPPLGVLPSASYKGGSLTVEPGDMLILYTDGAIEEKNSKDEEFGLERMIREVIARKHLTSQEIVEELFGLVRKFSGAPELFDDFTVMILKFNDNYQFSRIFEAKTSEIPLFREFVYQTIKVRNLEDSQRDDILLACDEAGTNIVMHGYENTDLKNPKFECKIRFTGDWITIVLIDSGKVFHREEVQDPSIEDNLSGKRKGGFGVYLIEKLMDSVDYSSEGGKNFLVLKKNFRNKASNGNNV
>NZ_CP043041.1|WP_000406879.1|2511821_2512151_-|STAS-domain-containing-protein
MEITSEIKNHSKIIHLIGNLDVHNTHKIESAFMEQIKTGNSRVIVLDLSSVEFISSAGLRIIVAALRICREKDVEFRLAGIKPAVKKVFEIIDMNSMFSIFETLESAIK
>NZ_CP043041.1|WP_001973770.1|2510077_2511730_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit
MSEAKYSLENPFQSTSEPEVLKPRGLYEEANELGKELLNKPLLGGGVDRILVQHSKDRMTVWERIKVLTDQEPNILYQNWGKSLDGASLVTGILNINGRDVAVYGHDFTLRAGSMDATNGSKLARLIYMAGEHGIPLIGMNDSAGAYVPAGVGGLDGYSEAFTALRKISGVVPSLMLMFGFNAGGGAYLPRQGSFMIQCDNTFFGLTGPGVVKSVLGEDISADDLGGPKVHGQSGVVDIVTGDELGSLRTALRLLSYLPDNNHSFAPFHATSDPTNRFIYEEEILFKKTFNSPTGMNTPFDITLYLQNICDHGQYFEIQGQRSRNLVTAFGRIGGHVVAFVANNSAVSSGQIDIGAARKGTRFIRFCNLYNIPIVFLEDTTGFLPGKEQEQNGIVLEGRKLLDSIIDIRTPRLTLIIRNAFGGAYACFNSYHTGADMVFALPTARIAVMGPAGKDYVYKDEVSSIQKEYQENVKKGMSEKEAIVIRDKKLQTLSTQYEKELMNPKEALSLGSVSRIVLPGTTRNILFQNLDYLIRHYKPAPLSGPQREFE
>NZ_CP043041.1|WP_002188258.1|2507326_2510071_-|biotin-requiring-enzyme
MIDFQNNRIQFHQSSSPWIRSFSLESIKCLIVCRGPVRKEAMEIFDSIGIREYGILLSEKDSVVYPMALAPELRGFRFPNNIHRVPDYMGAGKEEKMERIEQIISIAKDNKYTHIFAGYGFMAEDSEFISAIEKSGVVFMGPASYVADQAGSKDAAKKIARKLEVSVTPGVDNISSLALLAKAPDAKSLEKIAKEKGIDFIFDPSLSLEVNAENLLELGYSKIIEFVSIADLQVEAEKECKKIWEKYSKNRIRFKYIGGGGGKGQRVVSKPEEVKGAVQEILSESKVTAPGTNKNFLIELNIENTRHNEIQLIGNGEWCLALGGRDCSVQMHEQKLLELSLTQELLEKEIAACAATHPKKAEVLKGDLKVLREMEEQSERFGAAVKLNSVSTFESIVEGTNHFFMEVNTRIQVEHRVTEMVYSLKFKNPENQNEFFIVDSLIEAMALLSLHGKRLQKPERIFRFPSGAEVRINATNKAIQPHAGGVIMNWSKPLADEIRDDQGISIRNPDMGLFVHYKVAGAYDSNIALLISHGENRKDNLIRLGNILRKTELRGYDLQTNLLVHYGLIHWILGKDAMFKPSTSFMISYLAGVGALEKIIKDVDLEIAWKKIISEASADLKKVLSRKLTLITRPIGELIKDAHLSAGFIGFHLNRSWKISDSKIEWLRNPIFILADLYHYLNMEADPSLPPSEQIWDHDDEVLQKALSFYQELAKRTGSNPDSIELVASLNAGKSLNGIEAGLLPSILASHNGYQSGLELLKLLPYAGLNSGFYKLEVDEKLEAVIPEEFRKTETRDSLIKFLAPPPKASSDEIVAPMGGMFYSKEAPDLPPMIKVGDHFKAGQPLFIVEVMKMFNKISAPFSGTVKEILLNDSDGKIISKGQTIFKIVPDEVIHIETEAEITERKKKITLSLI
>NZ_CP043041.1|WP_025180781.1|2506914_2507253_+|YceK/YidQ-family-lipoprotein
MRIKPFFLILIVLQISIFLNCGTIFGIFQTYSYEKRMENRKSSMILGMPTDHSPIFAGVNFEYSMMKFLKAENIYFYLLILDFPLTILMDTVFLPISVPLSIHHYYKDKQQP
>NZ_CP043041.1|WP_002079097.1|2506511_2506646_-|hypothetical-protein
MQKFSDGFNISKIRSYKFFKILGQVQSNPLEFYGIYQAVSRIAL
>NZ_CP043041.1|WP_001080347.1|2520161_2521244_-|PepSY-domain-containing-protein
MNRKKLYKLHSILGISTGVFLVIVGLSGSLLVFGKEIDQLLNPNLWYISASKERLSIDVLRAKLKQELPSHALAGWLLSEKQNQPDQVWLHFLDSKDRKESIILLNPYTGKILGILSENRSDSFYSWMLKLHYSLLMGSFGYFLTTLFGVIFIFQGFSGMILYRRIWQNLFRLRTRQSLRTFFSDLHKLVGVFSLVFNISLGFTGAWWNVQAIVGLLSAQEERKVEKFFKESISVDSLLKEIKMQLPEFQTGFVSFPHHHEKDPIQFYGTERLTNPFRSRFGSYFRFDSESGKLLEIFNLSNENLFYTIIDSFRPIHYGTFGGIITKILWVILGLSPGILYISGIGILISKRNLQEKRKN
>NZ_CP043041.1|WP_139343781.1|2521586_2521769_+|hypothetical-protein
MFCDHDQNLNPILTRVWLRKNFLKVVVPTISEIVYKIVICSSPGPTHFTDKSKFCNSSRN
>NZ_CP043041.1|WP_001971044.1|2524813_2525887_-|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP043041.1|WP_100225741.1|2525958_2526153_+|hypothetical-protein
MRGQLCEVATHGFAVADLDSSMDRGLSPKRAINLPPAFLTPSIQEYHIRNCLTFKKHTNLQIAL
>NZ_CP043041.1|WP_002187457.1|2526484_2528701_-|leucine-rich-repeat-protein
MNFRITLIYLQKITIGLLFLITLSCEIQADEVEPGTYMDLTKALQNPLNVRILDLSGQNFTTLPKEIEQLKNLQELDLGDNQLATFPAVIVELQKLESLDLSENRLVMLPNEIGRLQNLQELGLYKNKLITFPKEIGQLQNLQTLNLQDNQLATLPVEIGRLQNLEKLNLRKNRLTVLPKEIGQLQNLQTLNLQDNQLATLPVEIGQLQNLQTLGLSENQLTTFPKEIGQLENLQELDLNGNQLKTLPKEIGQLQKLEKLNLDGNQITTLPKGNQLTTLPAEIGQLKNLQILSLSYNRLATLPREIGQLQNLKSLDLGGNQLTTLPREINKLKNLKELYLNGNKLTIVPKEIWELENLTILQLKNNRISTLPKEIEKSKNLQELNLRGNRLVTLPGEIGELKLLEELNLENNRIKILPNEIGALENLWIFNLSGNKLASIPKEIGNLQNLRMLYLENNQLKTLPRQMEKLQDLEVLNLLINPLLSEERKKIQALLPNCNIDLRDVEEGGTYRNLNLALEQPLKILSLSLEYQQFSLFPKEILRLKNLRSLSLYDTSLVALPKEIVRLKHLEHLSLGLNQLKSLPKEIGLLRNLRSLDIGANNEFEVLPKEIARLQNLRSLLLNQNRFKIFPKEIWELKKLVILNVNTNQLDALPEKIGRLKGLQMLDLSHNRLTTLPSEIGQLHNLTELYLQYNRIKMLPEEIARLQNLRKLTLYENPIPPQELDKIRKLLPNCEIRF
>NZ_CP043041.1|WP_000915022.1|2529598_2530570_-|membrane-protein
MLKKTSYFSIWQKGFKVSIFLIFYILFPSSVLSQAEENKKNTFELLIKRQTYRWTPYDYTSYTERSILETTIKTDSIKQNQKVLIPLVFRYDQLEKKFRIEVSAYEIELANPNTNVIESGTLGYETRKQYFNPMLRSEAELNYYKILNLYPNWDFFAGAGIRNINKYKYGYFLREGVYEEYFYTYGPQFVFRTEYRFAENWSLSLAADLFYTQGTRFYKPQALTLESMTVSAGTAGAQGIYRGYELDILLGYRVFDSVKFFVGYNYIYSYFSYYSFHQTDIRLQISSLDPFISENSSAPILHMFRSGNHDILQGLYLGMSVSF
>NZ_CP043041.1|WP_002187459.1|2530702_2530888_-|hypothetical-protein
MDSYGNRLETFLQGIEQLQKLEESNLSKNQFLSVPFARFKQKKLNLKLNKDVSKNRSTFLF
>NZ_CP043041.1|WP_033110667.1|2530878_2531061_+|hypothetical-protein
MNPTVIRNDIPLPTSVMYEKLVKQNVLNISPEPNPRVNDTVFPICRRFSVGLYLEEIKES
>NZ_CP043041.1|WP_002187461.1|2531057_2532638_-|hypothetical-protein
MNFRITLIYLQKITIGLLVLVTLSCEIQAEEVEPGTYRDLTKALQNPLDVRVLNLSGEKLTALPKEIGQLKNLQELNLKWNLLTVLPKEIGQLENLQELDLRDNQLATFPAVIVELQKLESLDLSENRLIILPNEIGRLQNLQDLGLYKNKLTTFPKEIGQLQNLQKLWLSENRLTALPKEIGQLKNLQTLDLQDNQFTTLPKEIGQLQNLQTLNLVNNRLTVFPKEIGQLQNLQDLELLMNPLSLKERKRIQKLFPDSNLDLREVAENGVYRNLNLAQEEPLKVFELSLEYKDFSQSFPKVILKFRNLRGLNLYDCGFSTLPKEISRLKNLKYLALGLNGLKNIPSEIGQLKNLEALNLEANELERLPKEIGQLRNLQKLSLHQNTLKIFPAEIEQLKKLQKLDLSVNQFTTFPKEIGKLENLQTLNLQRNQLTNLTAEIEQLKNLQELDLNDNQFTVLPKEIGKLKKLQTLDLRNNQLTTLPTEIGQLQNLQWLYLQNNQLSLKEQERIRKLLPLKCKIIFEVY
>NZ_CP043041.1|WP_002187452.1|2532708_2533995_-|hypothetical-protein
MNFRITLIYLQKITIGLLFLITLSCEIQADEVKPGTYMDLTKALQNPLNVRVLDLSGQNFTTLPKEIEQLKNLQKLYLFDNRLKTLPKEIGQLKNLQELNLSSNQLTILPKEIGKLENLQRLDLYDNRLTILPIEIGKLQNLQTLYLSSNQLTTLPRESGKLENLQELNLSDNQLTTLPQEIGQLQNLQTLNLKSNQLTTLFKEIEQLKNLQTLNLSDNQLTTLPIEIGKLQNLHTLNLSDNQLAILLIEVGKLQNLHTLNLSDNQLTTLPIEIGKLQNLHTLNLSGNQLTTLPIEIGKLQNLQDLNLHSNQLTTLSKEIEQLKNLQTLSLSYNRLVILPKEIGQLQNLQELNLWNNQLTALPIEIGQLQNLQTLSLYKNRLMTFPKEIGQLKNLQTLYLGGHNQFSSEEKERIRKLLPNCKIYFGDN

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Crispr_ID: NZ_CP043041_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_3

2796533-2796628

Orphan

Consensus_repeat	Method
AGGAAAGCGTTGTGTTGAGTTTTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043041_3

>merge|NZ_CP043041|3|2796533-2796628|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCCAACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTGAGGAAAGCGTTGTGTTGAGTTTTCC

>NZ_CP043041|3|3|2796533-2796628|CRISPRCasFinder
AGGAAAGCGTTGTGTTGAGTTTTCC	AACGCGACCTGCAGAGCGACCCTTAGGGAGCGATGCATTGAGTTTG
AGGAAAGCGTTGTGTTGAGTTTTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_000564257.1\|2790681_2790858_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002119423.1\|2793256_2793526_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002187789.1\|2799414_2801127_-\|peptide-chain-release-factor-3	unknown	unknown	gnl\|CDD\|179105
NZ_CP043041.1\|WP_000815636.1\|2794902_2795262_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|367760
NZ_CP043041.1\|WP_029758342.1\|2797176_2797701_-\|DUF1493-family-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002105649.1\|2785505_2786615_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|226434
NZ_CP043041.1\|WP_000939052.1\|2793963_2794911_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|240081
NZ_CP043041.1\|WP_000332802.1\|2791578_2792001_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000825586.1\|2804964_2806074_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001165809.1\|2788293_2790600_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_085975572.1\|2798484_2798670_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000203920.1\|2795594_2796014_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366911
NZ_CP043041.1\|WP_000568850.1\|2801830_2802331_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|133459
NZ_CP043041.1\|WP_080010667.1\|2807096_2807894_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP043041.1\|WP_001068702.1\|2803787_2804585_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|223282
NZ_CP043041.1\|WP_000837198.1\|2797864_2798242_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227933
NZ_CP043041.1\|WP_001968065.1\|2792110_2793070_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|368185
NZ_CP043041.1\|WP_000127192.1\|2806218_2807100_+\|DUF2225-domain-containing-protein	unknown	unknown	gnl\|CDD\|378340
NZ_CP043041.1\|WP_000623976.1\|2802327_2803791_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|227111
NZ_CP043041.1\|WP_000142583.1\|2787151_2788297_-\|DUF445-family-protein	unknown	unknown	gnl\|CDD\|377281

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_002105649.1\|2785505_2786615_-\|histidine-kinase	gnl\|CDD\|226434	COG3920, COG3920, Signal transduction histidine kinase [Signal transduction mechanisms].	1.06766e-42
NZ_CP043041.1\|WP_002187789.1\|2799414_2801127_-\|peptide-chain-release-factor-3	gnl\|CDD\|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
NZ_CP043041.1\|WP_000815636.1\|2794902_2795262_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|367760	pfam03992, ABM, Antibiotic biosynthesis monooxygenase. This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.	6.60243e-16
NZ_CP043041.1\|WP_001068702.1\|2803787_2804585_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|223282	COG0204, PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism].	1.6769e-09
NZ_CP043041.1\|WP_000203920.1\|2795594_2796014_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|366911	pfam02082, Rrf2, Transcriptional regulator. This family is related to pfam001022 and other transcription regulation families (personal obs: Yeats C).	6.79677e-30
NZ_CP043041.1\|WP_000568850.1\|2801830_2802331_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|133459	cd06850, biotinyl_domain, The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.	1.99904e-26
NZ_CP043041.1\|WP_080010667.1\|2807096_2807894_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	2.42801e-95
NZ_CP043041.1\|WP_000939052.1\|2793963_2794911_-\|nitronate-monooxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	4.46595e-89
NZ_CP043041.1\|WP_000837198.1\|2797864_2798242_-\|hypothetical-protein	gnl\|CDD\|227933	COG5646, COG5646, Uncharacterized conserved protein [Function unknown].	5.30994e-28
NZ_CP043041.1\|WP_001968065.1\|2792110_2793070_-\|amidohydrolase	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	6.09454e-41
NZ_CP043041.1\|WP_000127192.1\|2806218_2807100_+\|DUF2225-domain-containing-protein	gnl\|CDD\|378340	pfam09986, DUF2225, Uncharacterized protein conserved in bacteria (DUF2225). This domain, found in various hypothetical bacterial proteins, has no known function.	6.00995e-67
NZ_CP043041.1\|WP_000623976.1\|2802327_2803791_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP043041.1\|WP_000142583.1\|2787151_2788297_-\|DUF445-family-protein	gnl\|CDD\|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	7.05074e-12

>NZ_CP043041.1|WP_000203920.1|2795594_2796014_+|Rrf2-family-transcriptional-regulator
MTSRFTVAIHILSLLSLGEGKTKTSEELAESVNTNPVVIRKILSLLKNQGIVRNQMGPNGGYVLAKTPASINLKEIYEAIDEKIFQMHSKSPNKKCICGHAIQPILSKVYEKAQKVLEEELGSTDLDSITKEILNFSKK
>NZ_CP043041.1|WP_000815636.1|2794902_2795262_+|antibiotic-biosynthesis-monooxygenase
MKQVGFFLPNDSIFKNSVPMIVVVSSYKVLEEKIEEFKKASQEMAKESTESEEGVLRLDVLQGDGDPGRFLFMEIYKNETARKQHLESPQFISWRRAVPEWFSQGSTSIQYIPVHIDFK
>NZ_CP043041.1|WP_000939052.1|2793963_2794911_-|nitronate-monooxygenase
MLQHIEIGRILKMKLNTRITKMLGIDLPIIGAPMFLVSYPDLVVAVSEAGGIGCFPSLNYRSPEQLKDGLQEIRSKTKKPIGVNLILHKSHNPNWSKQLQVVLDAKVELLITSLGSPRTVVNEAKSVGAKVFCDVTTLKHANIVAKAGADALIAVAQGAGGHAGNISPFSLYPYLKKETGLPIVAAGAISSGAQMLAAFSLDADAVYVGTRLIATPEAQASEEYKKMLIDSGPEEIVYTEKISGIPANWLKKSVEKAGDLSHSGQSQNLDQEYKRWRDIWSAGHGVAQIQGLIPAREVVLGMAKEYSDILNRLPR
>NZ_CP043041.1|WP_002119423.1|2793256_2793526_+|hypothetical-protein
MHLILSAVKIGAVLFWIVFGALLFGFISVEFHLSFLIKAVGYGTLVVHLLEIVYFWFLLRNKSNNLFLDCIQILIFGVFHMISLRNKRA
>NZ_CP043041.1|WP_001968065.1|2792110_2793070_-|amidohydrolase
MLPCCHHLLSSNRISNETSPFPWKDPKCLPPLRDDQSPEHIPLMEKYGIPFLIDIHTHFFPEYVMKQIWKWFDGVHWEIAYRETETKRLEILNRNRIFHFTTLNYAHKAKMAEGLNRWVYETHTKTKGAILFGTFFPEEGCLDYTKRAVEEYGFCGFKLHCEVGRLDLTRADLSETFYYLEKKEIPIVIHSGDAPLPGPYTNIRYFKSFIERYPKLKVIVAHMGASEVWEYSELLEIYPELRMDTTMVFVDFLATGENTNSYLEILERYPDRIHFGSDFPNIPYALSHPICNLLNTSLSEEIKRKIFLENSAKLFGISI
>NZ_CP043041.1|WP_000332802.1|2791578_2792001_-|hypothetical-protein
MCDFLKRIFGFILAGFLTIQCGKKNSTQSEETYKRVADAYCTQMNRCKEPYLSSLEGKFRKEAALTYPDNVQCYSDFNYDYDKSEPIVLKKLSDNLKLEAELCIKSVKRADCGSIVTYQIPECAEYNTFLETISIPSLTK
>NZ_CP043041.1|WP_000564257.1|2790681_2790858_-|hypothetical-protein
MIDAKNLKSQKESDMSYKMDGAKFQTMEELIDAFYPLYSDTMSEDDFEKYVQENAKEE
>NZ_CP043041.1|WP_001165809.1|2788293_2790600_-|hypothetical-protein
MQIIQRKWKIPHAARKPLVFFLVFLFLSVQFRFLFSDQVPDSVSLQNQYLIAQDYQILFKNFLSSGYDRSLQGGSPIFYFQAPFFFFLVSFLHTFILFFLPFGVSFNLGILLGLFLFSYAFLKLGFLFLTETNLSPGNTLLTITGLMFYFLYPGDRVVGAGIVGVFQNSISFSVGLAIALLSIYYLEKFRYTGKVSSFFKNLIAGTLVFYTHYETSLFYLIALGIYFLFYKDEFEILEILLIFLVPLLFAFPILWNYFAYISFQQNPPVSFPINGLLSLLGEEFSNSIARPEKILDLIKQILMDQYWIHLLFPILFVIGIRLLFIRKLLPPISRFLIFGALFFYWMATDSSLSMIFPWLHAKWHTALNVSLVFLTLSSLVTARFFLKNLPPGKWKLWSGLILFILGLYRFIVTIPGPATGIETFTDNPSVIWKQKEEWIRVFEKTSYGALIASEEILEEKDFADSRWASVLIRQSVRRNITLKNRFEKSFPASIEEIIRLFPEQGTKTFLNKEEKQINFHPALEREKLSELFSKLLSERGVSYVLLGSDSLNQLAIVSPKYFYKIDQKGKWILWKLNSSRSFMELLPKKPIAILIEDFSLQKLKLESVLDLKFEQNLTLIPVSKEEFKSDQNSFSDVCEVSSCFREKVKEKESFQNKTGTKTDLVGLPTEIWPVTWSDSEIRWEISKEKQSEVCFPTLVHSSFFPLWKLVSGEKVYRTLEDQFYFCSKERKNEFIFYDIRTYLITFVQLLLPLAFLGATFLTRRKVSN
>NZ_CP043041.1|WP_000142583.1|2787151_2788297_-|DUF445-family-protein
MTFFTKDLRKTPFRKRQTLSNSILIGFSAAILFILFLGNPETPIVKIILSALEGGLIGGFCDWFAVWKTYKAIEEDGSKLSTEIGNWVANDLLHHEVIRSRIRMVLEDPSTRNEVHEVLLETFGNEEKTKEVLNGLFSKVEEEIVQYLIHYQFSGTDVALLKELNRQKEIMDTIKLLIGESMIKVADTEEFKSLLQEILGKMNLVAQVVLNLIVDFPKKLKEYGNHVKQGLEIESKDEKTIEKLVSLMAASSETYISSWNELRLDQREKAVRSLMGFLKDQSSRLLAALIQTHLKEIGEVKTLQEYSPLRAVLEFVEKRIDENVSGYIGRQITVRLQSLEPKDLRKNLEWKTRNVLETIRINGSILGFFLGCITGLIRFFF
>NZ_CP043041.1|WP_002105649.1|2785505_2786615_-|histidine-kinase
MVFEKFKRIYAQEPFILRVRALYLLLFNVVVFMFASLSFTFFFNEKEPTYRPSYILFIIASFLSIFLLWIGQFKKALFLTLFSVATGLTWVLLFGNPIGNALWSLSILVILFLLFTDIRTTLYISLFSFILILLFFYRLNLMDKLNSVFVLDSIIGFILFTLLAFLIVNLLNSYIKEKDELIKEIHHRVRNNLQVLSGLAILHNKDDADLQRVLFEFQNRILAMSEVHNYLYKSDNYHSIEFSNVIEKIIENLKSKHKDSKITILNYSEKINLPIEKAIPCAMIFNELLNNSLIHAFKESKNPNIEIHFSKNVSIYKLAVKDNGTGMAIPENWKNSNTIGFTLIQILSRQIHANFEIFNDRGLVAVLEF
>NZ_CP043041.1|WP_029758342.1|2797176_2797701_-|DUF1493-family-protein
MRFVYEFESSKKIDILRISKKIFICIVRHTRKDLDKLSLKTCIVKDLRISGDDVDDLVQDINRYFQIDWSSLNFKEYFGGEGFSIVEFFVFLIRFILNLISNLMKTILRVLINFNFSRFNFFKNNQKDFQIENLIIAAYYGKWDNTLLSHSIPIKKEIQNWQIQYWNRFKRRYY
>NZ_CP043041.1|WP_000837198.1|2797864_2798242_-|hypothetical-protein
MKSKKLNFKNIDEYINNFPKDLQDQLKKLRSTIRKAAPNAEEKISYQMPTFALYGNLVYFAAYKKHIGFYPTSSGIKEFQSELTEYKTSKGAVQFPIDQPLPLKLIAKIVKYRVKENIQTKKSKS
>NZ_CP043041.1|WP_085975572.1|2798484_2798670_+|hypothetical-protein
MLKFVRKILVCSSSYIILQINLSFVVVPTFEESICKVQILTLFRIMSFLRRAHVKINEYSE
>NZ_CP043041.1|WP_002187789.1|2799414_2801127_-|peptide-chain-release-factor-3
MALNLVGISRSNCPFGLVNDSRFYKKNLEGGRSKTVSDTVEQKSNRTIEEETRRRRTFAIIAHPDAGKTTLTEKLLLYGGAIQLAGAVKARKNRKAATSDWMEMEKEKGISITSAALQFEYSGHVLNLLDTPGHEDFSEDTYRTLIAADTAVMVLDAGKGVEPQTIKLFKVCRDRGIPIVTFINKMDRPTKNLFSLLDEIEKVLGISAVPMVWPIGTGVDFSGVYSRKDKKILTYDKTPGGSQKSTFQTSGVNDPELDSRFEDWVIKTFREELELVEGGISEFSQEDFLDSKITPVFFGSAVNNFGIQLFLDEFIKIAPPPLFFPLKDGSKLDPIQTPFSGFIFKVQANMNRQHRDRIAFLRVTSGKFERGLNVLHGRLGKSVKLSSSFAFFGQDRNTVDEAYPGDIIGLVNPGTYAIGDIVASSKVPDLKSLPVFAPELFATISSSDTSSMKSFRKGIDQLAEEGILHLFSSQTIGGGLPIIGAMGQLQFEVFRRRLLDEYNAPSTITILPYVISCWIGQEDLGKVPSSANLVTDRGGRAALLFDTEWDKGYFQKKNPEITLLDYPPSI
>NZ_CP043041.1|WP_000568850.1|2801830_2802331_-|biotin/lipoyl-binding-protein
MIEENFRFRHREEEIPVRVRSGSPGDVSVSITLGGVVHDFRISRNFQSEGNGLFSGPGNHWRILRKGNQIFIHHKGWNTKVLLSNREIHLEEGSGGLIKSPMPGKVIRVGVSVGTTVKKGSVLAIVEAMKMENNLLSPGDGIVEEVLVKEGNMVSQDDVILKLNLG
>NZ_CP043041.1|WP_000623976.1|2802327_2803791_-|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSYLNISNILEAIKKTKTDAVHPGYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKATAGGGGKGMKRVYKSEEFLFALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIEESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDSKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIQVAEGKKLSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREECTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKEVQADAFSFAAAALSEKKKSQGIWEAVGPGGFW
>NZ_CP043041.1|WP_001068702.1|2803787_2804585_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MNPLKFMESRLGRFPKSYRKIVLKTYLITIVLVFSFAFPSLVAGLFFALIGNQKRKNASFLKGSAVWADAIIWMTKTRFFKIGDFQIPPKGHMIFSNHVNELDFPYDCLVINKPYLANQVIKKTLIAYWWMRAMGSQVFETTKAATIAVSVRNVLKGLDTTSFVVYPEGHNSYREEIQPLQKGMIKLAWENKIPVAIVLKSGLTGYQTLEKGFVVAYKQAGIYDPTQYSSWEEFKDFIFETMDREKKALDSMLSSEVQKESVLVS
>NZ_CP043041.1|WP_000825586.1|2804964_2806074_-|hypothetical-protein
MKRLILISILISILPVSVFGEAVSSKAYKKRVELLLYLRAIEPIVRNYKGEVPGGQNQQNTGATAANNQQTGGAPEQDGDRVKKYKELKRLYQEGLQYFFENNHVNAYRRFLEAQLGTEMLLEELSQFYVERTEEILKSAIEKKNPNNPEDRNLVDIAIEWSKNSFIVRDMTANREAPLTRRMYNPRDFHYVTNKYAIEKNMEMGYKFLGLAKETRNNALKIEKHLEKHQKLQPSHRKHRIEHYIAAIQLCRDARANAINIFKLKYPYDNYYLFKSDAKTEAIKDDEGKAGPSEPVSLNGVTYDFSQNPTLEYDHRMSPVFDRRIPEEYRRDAVDILEKIYDDEVKNRIFLKWDQEKRKQLMGDKAPNK
>NZ_CP043041.1|WP_000127192.1|2806218_2807100_+|DUF2225-domain-containing-protein
MTASALAQGKKISFRAKEDTVCPICNEVHQKENMFQGGGRLIAGKLTIELRRLYEKNKKFGRVSPNDYVISVCPRCLYSSFSKDWSTLDAEEIEKVRSQFDTRRSNLEKILGPLDFYQDRNLVLGAASYLLAIECYQNRKATVAPTPKKAVCSVRGAWYFEDLNNDFPNMGFDKVRDLLYQKAAGWYTETMEIMQSGSEPVDQASYILGPDTDKNWAFDGVIYLSAYLTMKFRDELAPDPAAKLNLLVRAKRTLSRLYGSGKGSKSKPSVIIDMAKELYDEYSKLIEEMGGEK
>NZ_CP043041.1|WP_080010667.1|2807096_2807894_+|tRNA-pseudouridine(38-40)-synthase-TruA
MNYALLVEYDGLCFHGFQTQKGLSSIQENLEKAAKILLKEEIHISGAGRTDTGVHARGMIVNFKTQRVIQNFSKFLLSLNAITDSGLSILNMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK

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Crispr_ID: NZ_CP043041_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_4

2812552-2812718

Orphan

Consensus_repeat	Method
TCCCATTTTAATTCATTATGTCTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043041_4

>merge|NZ_CP043041|4|2812552-2812718|CRISPRCasFinder
TCCCATTTTAATTCATTATGTCTTTTGAAAGTTTTTCAATTATTAAAAAATTGTATTAGTTTTCAGAATTTCACTGTAAAACTACAGCTTGAAAGAGTTCCCACAAATTACGTCCCATTTTAATTCATTATGTTTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA

>NZ_CP043041|4|4|2812552-2812718|CRISPRCasFinder
TCCCATTTTAATTCATTATGTCTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA	TTAGTTTTCAGAATTTCACTGTAAAACTACAGCTTGAAAGAGTTCCCACAAATTACG
TCCCATTTTAATTCATTATGTTTTTTGAAAGTTTTTCAATTATTAAAAAATTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_000672053.1\|2818421_2819165_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000465997.1\|2817357_2817768_-\|6-carboxytetrahydropterin-synthase	unknown	unknown	gnl\|CDD\|376501
NZ_CP043041.1\|WP_000900432.1\|2822261_2824205_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP043041.1\|WP_001068702.1\|2803787_2804585_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl\|CDD\|223282
NZ_CP043041.1\|WP_000693594.1\|2815158_2816163_+\|sulfate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224529
NZ_CP043041.1\|WP_000825586.1\|2804964_2806074_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000141324.1\|2817895_2818123_+\|DUF1858-domain-containing-protein	unknown	unknown	gnl\|CDD\|274898
NZ_CP043041.1\|WP_000801434.1\|2820769_2822275_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
NZ_CP043041.1\|WP_000127192.1\|2806218_2807100_+\|DUF2225-domain-containing-protein	unknown	unknown	gnl\|CDD\|378340
NZ_CP043041.1\|WP_000568850.1\|2801830_2802331_-\|biotin/lipoyl-binding-protein	unknown	unknown	gnl\|CDD\|133459
NZ_CP043041.1\|WP_002187841.1\|2819551_2820334_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001971044.1\|2810813_2811887_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_080010667.1\|2807096_2807894_+\|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl\|CDD\|234577
NZ_CP043041.1\|WP_000964329.1\|2824715_2825813_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
NZ_CP043041.1\|WP_000599731.1\|2824206_2824719_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
NZ_CP043041.1\|WP_000464604.1\|2808759_2810001_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_100225746.1\|2811958_2812201_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000739010.1\|2813300_2815130_+\|alginate-export-family-protein	unknown	unknown	gnl\|CDD\|372583
NZ_CP043041.1\|WP_000623976.1\|2802327_2803791_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|227111
NZ_CP043041.1\|WP_000492790.1\|2807896_2808715_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_001068702.1\|2803787_2804585_-\|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl\|CDD\|223282	COG0204, PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism].	1.6769e-09
NZ_CP043041.1\|WP_000693594.1\|2815158_2816163_+\|sulfate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224529	COG1613, Sbp, ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism].	0
NZ_CP043041.1\|WP_000801434.1\|2820769_2822275_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	5.93069e-65
NZ_CP043041.1\|WP_000141324.1\|2817895_2818123_+\|DUF1858-domain-containing-protein	gnl\|CDD\|274898	TIGR03980, conserved_hypothetical_protein, hybrid cluster protein-associated redox disulfide domain. Members of this protein family resemble the domain of unknown function DUF1858 described by pfam08984, but all members contain an apparent redox-active disulfide. In at least one member protein, a cysteine in the CXXC motif is substituted by a selenocysteine. Most member proteins consist of this domain only, but a few members are fused to or adjacent to members of the hybrid-cluster (prismane) family or the nitrite/sulfite reductase family. [Energy metabolism, Electron transport].	1.06335e-17
NZ_CP043041.1\|WP_000127192.1\|2806218_2807100_+\|DUF2225-domain-containing-protein	gnl\|CDD\|378340	pfam09986, DUF2225, Uncharacterized protein conserved in bacteria (DUF2225). This domain, found in various hypothetical bacterial proteins, has no known function.	6.00995e-67
NZ_CP043041.1\|WP_000568850.1\|2801830_2802331_-\|biotin/lipoyl-binding-protein	gnl\|CDD\|133459	cd06850, biotinyl_domain, The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.	1.99904e-26
NZ_CP043041.1\|WP_080010667.1\|2807096_2807894_+\|tRNA-pseudouridine(38-40)-synthase-TruA	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	2.42801e-95
NZ_CP043041.1\|WP_000964329.1\|2824715_2825813_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	4.05585e-52
NZ_CP043041.1\|WP_000599731.1\|2824206_2824719_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	6.58697e-07
NZ_CP043041.1\|WP_000900432.1\|2822261_2824205_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP043041.1\|WP_000465997.1\|2817357_2817768_-\|6-carboxytetrahydropterin-synthase	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	7.99295e-37
NZ_CP043041.1\|WP_000739010.1\|2813300_2815130_+\|alginate-export-family-protein	gnl\|CDD\|372583	pfam13372, Alginate_exp, Alginate export. This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel.	1.64429e-18
NZ_CP043041.1\|WP_000623976.1\|2802327_2803791_-\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP043041.1\|WP_001971044.1\|2810813_2811887_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	6.8024e-27

>NZ_CP043041.1|WP_100225746.1|2811958_2812201_+|hypothetical-protein
MRGQLCEVATHGFAVADLDSSMDRGLSPKRAINLPPAFLTPSIQEYHIRNCLTFKKHTNLWIAFYIETKDDYYIMFSVCN
>NZ_CP043041.1|WP_001971044.1|2810813_2811887_-|IS110-family-transposase
MKSQEIKYVGIDCGKKTLEVIRIGDNSLHQRQQFSTTEIGISKLINWLNPNDVVGLEAGSQSFRIAKSILNKGIQVIVLNPGDLATIYQSLKKTDKEDSLKIARLIQRFPIEELPTVPIPNDEEEDNRRLCTEQENWTRQLTQSKNRLHSLFTQAGLTHITKKHLRTKANREISVALLPSRYQKEAERILKVLDLVEQNLKLIEEEIKEALKKNKAYAQTIMSMPGIGMITSLAIMSYMGNCKRFSSAKQAAYYVGLVPRVDISGDSAYYGRIVNRGCHSIRRVIVQAAWSLVRCQYGGKIKEFYQRLYPKKGAKKSIIATSRKMIEILYTMIKTGELFDSMPEKVLNRKLTQYGLM
>NZ_CP043041.1|WP_000464604.1|2808759_2810001_+|hypothetical-protein
MFFCKVGDWHGKHSKNPVISTLFNQRMLLLVKGTYATDNPIGFEAYSGGTGQLYQDTSGEGADPAFGLDGVPLAQNLPIFIDIGEIRLSTKYQEGAFDLSLVKNVKDTKSLWDEIAPNRQVFCTIPYTTNSNSCRLNDGEFKAIQFFNGEGVAYPSNDPTSATDWGAFGNGPVQFYYTGLYLRSLVTAWATEPGLTFSNLTLFDNYRVPGINIVPRLSYKPGADATTKSVFPPLVFPVLYKAEKGDQDMLIYPGFDPYILEVRINLKENLMIHSYVSSIGGVRTLVGISDWKPDSDHKGESDMGGGLLVRSRIIRPEKASSLTVLGGTTSTTHYYSVYRLSESEIDTKLPLMASPVQGVSTKMKYIHSGDYRLRCMGDLAKVDGYPETVVRETVFTVPENAPHSEVQVNLTCP
>NZ_CP043041.1|WP_000492790.1|2807896_2808715_+|hypothetical-protein
MFSRCRIFLKPTTLIWFAILPGALSASPQKPGTFELLGGYQPNWNRLFTEFLPKRTAQTGNLPSSGVISREEEDIENPEETEEDKQEGYQDNRKTEVGVWVGASNPLPGTETQKYLDTTLGGGFFFRIPWPWIFYLEMGAFYANYLSATERALTTIPVYLALGYKIPLDLPISFILRAGGGEAFVVARPSNTSRWDPMMIVGLETSFVAGKKIRIGIRIDYNKIYESRMDAPRETKYPYTSPYEDSRLSNPNYYRVVDTEFFQFGLMVSVFL
>NZ_CP043041.1|WP_080010667.1|2807096_2807894_+|tRNA-pseudouridine(38-40)-synthase-TruA
MNYALLVEYDGLCFHGFQTQKGLSSIQENLEKAAKILLKEEIHISGAGRTDTGVHARGMIVNFKTQRVIQNFSKFLLSLNAITDSGLSILNMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK
>NZ_CP043041.1|WP_000127192.1|2806218_2807100_+|DUF2225-domain-containing-protein
MTASALAQGKKISFRAKEDTVCPICNEVHQKENMFQGGGRLIAGKLTIELRRLYEKNKKFGRVSPNDYVISVCPRCLYSSFSKDWSTLDAEEIEKVRSQFDTRRSNLEKILGPLDFYQDRNLVLGAASYLLAIECYQNRKATVAPTPKKAVCSVRGAWYFEDLNNDFPNMGFDKVRDLLYQKAAGWYTETMEIMQSGSEPVDQASYILGPDTDKNWAFDGVIYLSAYLTMKFRDELAPDPAAKLNLLVRAKRTLSRLYGSGKGSKSKPSVIIDMAKELYDEYSKLIEEMGGEK
>NZ_CP043041.1|WP_000825586.1|2804964_2806074_-|hypothetical-protein
MKRLILISILISILPVSVFGEAVSSKAYKKRVELLLYLRAIEPIVRNYKGEVPGGQNQQNTGATAANNQQTGGAPEQDGDRVKKYKELKRLYQEGLQYFFENNHVNAYRRFLEAQLGTEMLLEELSQFYVERTEEILKSAIEKKNPNNPEDRNLVDIAIEWSKNSFIVRDMTANREAPLTRRMYNPRDFHYVTNKYAIEKNMEMGYKFLGLAKETRNNALKIEKHLEKHQKLQPSHRKHRIEHYIAAIQLCRDARANAINIFKLKYPYDNYYLFKSDAKTEAIKDDEGKAGPSEPVSLNGVTYDFSQNPTLEYDHRMSPVFDRRIPEEYRRDAVDILEKIYDDEVKNRIFLKWDQEKRKQLMGDKAPNK
>NZ_CP043041.1|WP_001068702.1|2803787_2804585_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MNPLKFMESRLGRFPKSYRKIVLKTYLITIVLVFSFAFPSLVAGLFFALIGNQKRKNASFLKGSAVWADAIIWMTKTRFFKIGDFQIPPKGHMIFSNHVNELDFPYDCLVINKPYLANQVIKKTLIAYWWMRAMGSQVFETTKAATIAVSVRNVLKGLDTTSFVVYPEGHNSYREEIQPLQKGMIKLAWENKIPVAIVLKSGLTGYQTLEKGFVVAYKQAGIYDPTQYSSWEEFKDFIFETMDREKKALDSMLSSEVQKESVLVS
>NZ_CP043041.1|WP_000623976.1|2802327_2803791_-|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSYLNISNILEAIKKTKTDAVHPGYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKATAGGGGKGMKRVYKSEEFLFALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIEESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDSKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIQVAEGKKLSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREECTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKEVQADAFSFAAAALSEKKKSQGIWEAVGPGGFW
>NZ_CP043041.1|WP_000568850.1|2801830_2802331_-|biotin/lipoyl-binding-protein
MIEENFRFRHREEEIPVRVRSGSPGDVSVSITLGGVVHDFRISRNFQSEGNGLFSGPGNHWRILRKGNQIFIHHKGWNTKVLLSNREIHLEEGSGGLIKSPMPGKVIRVGVSVGTTVKKGSVLAIVEAMKMENNLLSPGDGIVEEVLVKEGNMVSQDDVILKLNLG
>NZ_CP043041.1|WP_000739010.1|2813300_2815130_+|alginate-export-family-protein
MKKNAIFKVSAGALLFCCIIPLNLFSQNSKKEKTNGPVLNLDPPSDVRYEEQPNDGKGIPEIQEELAKEEPYKSPYKGKLPGEFMKSMLLSPEHQEAIRRTDKLWFGDIFRTGFQIRPRFDYSHNADFDKRTQDDRNYATQNSQVFFVVDPNPYVAAKVTIQDVRVFGGEQSRKDGQLGYLGLSNSAGIELSSAPTANNSVSIKNNTDLREGFVQLKNFADGFEIFIGRQIFGFGDNRYVGGRNDGQTGNSFDGARVKYNSKYFNSEAFTSIIAEDSNAGAGNNTANGVKRGTVNDTYLSGLYNTVKFEDFNVDLYYFNVDRKWEQGPNPATSQDRTRQRDDLNTVGFRLTNRTDNNRLPKTKAWDWTLEASWQYGYNGQRVNAGWDTLKQTVDGNPNSKRIYTERVEYDSKFFIAQTGYTFFDRFRVGIQYSIGSGDPNRTDNKVATYDASFATRSGGFPYFDSGNGIANATFWSNTRTKSIHLMYNSPNYGRFIFVVYDIQKASVNDAWYSSGGAANTGLTTENPTGAAFGGYKLGEKGGKRLFYEFDLIYQFYLKDYVSIWTGGSYLLAGDAVRNARVNPWAPNINDRYTLDNRAYSFFLFVQFAM
>NZ_CP043041.1|WP_000693594.1|2815158_2816163_+|sulfate-ABC-transporter-substrate-binding-protein
MKIKFFKITTIVFFTMTSNLGLFAKDITLLNVSYDPTRELYAEYNKLFASYWKSKTGDEVRVNQSHGGSGKQARSVIDGLEADIVTLALAYDIDIIASKGLISRDWLKSLPNNSTPYTSTIVFVVRKGNPKNIKDWDDLVKSKISVITPNPKTSGGARWNYLAAWAFAQKKFNNDTNKVQDFIKTLYKNVPVLDSGARGSSNTFAQNGIGDVLIAWENESFLILEEFGKDKYEVVIPSLSILAEPPVAIVEKNADKHGNLETAKAYLKSLYSEAAQEIIAKHGYRPRSQTILKKYETKFPKLDLITVDGHFNGWQKAHKDHFADGASFDQLYVK
>NZ_CP043041.1|WP_000465997.1|2817357_2817768_-|6-carboxytetrahydropterin-synthase
MFFQESGRFYIRIEERFESSHYLYKYFPDGSDEPIHGHSWKVELYLSGKKNIGDDGISFDFLTSKQKLKELVGRLDHILINDLEEFKKINPTSENIARWFYHYLKESVHTAGGKVDRIVIHEGPENLAFFEPTSLS
>NZ_CP043041.1|WP_000141324.1|2817895_2818123_+|DUF1858-domain-containing-protein
MTEVVKPRFYKEMTVGEAMAVHPEAGLVFSSYHLGGCSHCSINELETIEQVCMGYGVEVDVLVESLNNLLEDSED
>NZ_CP043041.1|WP_000672053.1|2818421_2819165_+|hypothetical-protein
MKFRFQKLGSIFVCIFYNLFFSFVSLEAITIEVFIPLCDGKSLVCGKGKAGDPRSLEENLYWGAAFGAETFFKRNSNFKILEIKERKLDSPILRTLIIEKKRKQNETYTKLIIYAYAGDKIDNALLDFLNASSGKSLADIIVWSGHNRLMDRISPKLQSQSAKTVAVLACESEKYFDSVLRSIGAKPIVLTKTFMAPEAYLLEALTETVSKFGAEDKKSIRSAMIRSYAKYQKISLKAAGSVFSKLE
>NZ_CP043041.1|WP_002187841.1|2819551_2820334_-|hypothetical-protein
MDPVKDSRFFFDLKRKFEVILEEVEKKTFDQKDEIRELESLWEEMFELAGKNDSPYFQIRLKNLKKQLETFVKNKGYEKQEFDRIYHQLGKMKQNDSVEFLDESLRNRLERIAQKHYSPGDMTSSEVVATSKKGKYYITFRCGTIYFITDWSSYTVLKDLDRRKNTVEYKGSVYRIFPSAFVYGLSEEEYRNENFLTMNLLVLKRESGLEFYRFDTLGEILQINEGTFLKGLKPIESSEIDKRIRNYFRKAGIRYYYIPV
>NZ_CP043041.1|WP_000801434.1|2820769_2822275_-|rod-shape-determining-protein-RodA
MKPDKSIEKIDYFLVISVVIVVLCSVTTLYSQEVNFEDGPGKWYRQLFYFIIGLAIMYFVSRVNYQLLGAYALVIYVFTVFLLMITLIPGIGYLPSGRGARSWIKLGPVGIQASEFAKLSTVILLGQFMVLKEKDMRNLVVLSIPFIIVIVPMIFILLQPDFGTAVSFLPILFTMLFLGGADILHIGSLLAFGGITLMVPMFVEYSKLTLINDISDFLQRTGKTDLLSVVNRLGGKIWLALDGKDVKAANLTPKTLNALQEVVDQVVEVEGGFFFKIFSNQKLLLTFGALFLIASIVMVGIRIARGSKTLRQYYIPLGILGISLISAVVVMKTVPFRENQVIRLTAFLNPEEFKQGAGYHLRASKPAVGSGRFFGKGLMNAEMTEGRIPHVPESSTDFIFASWAEQTGFLGSVFLLFFLFSIPLRGLQISYESKDRFGSLLASGIVALLFYHMAINIGIVIGLMPVTGIPLSFMSYGGSHLVMSMTAVGIILSIKSRKHAN
>NZ_CP043041.1|WP_000900432.1|2822261_2824205_-|penicillin-binding-protein-2
MLGGAQSASEYRLEKSFRLRLYTFSGLVVFALAAFIFQLFNLQILNGTDNALKAEKFVRKSEIMPAARGQMFDRNFLTPETSMALVSNYSSLDVVLNTSLFKYDPTSVKAFIQEFARTLSIPISYYQDELIEPRFSRNLKAKKPIVLLEGISTAQQERISVFDNISKYIVLLPSPRRVYKMGPALAHVTGYIGKPTRDDLVSGKIKSYQYLGKDGLELEYDSELRGVDGFRIQKRSSEGNIEEERVVEHSSPGNNLVLTIDKDIQIAAYKALKGSRGTAIAIKVATGEILAMVSNPSYDPNILSGKNRADRTAHFKRVKDNGGFLNLAIKSKFPPASTYKTLVALAALESQHKIGYTPETTFSCNGSFVLKSTFAGVPDQVFLCWEKGGHGTNDLAHALQKSCSVYFYNLGYKLGSDAILNYSRLFGLENKSKVDLPDETAGFVPSSAWKKRTYGTKWFDGDTINLSIGQGFISTTPIGMALFYMGLLNRGQIYQPYVVSEIRDPVDNSIINRTTPQILRDIPINQSSVEAIKEGLKLVVKSGTAAHVLNKPFLPEIAGKTGTAQTRRRGASGSNHAWFVGYAPANAPASEQVLVVVFVEYGIGGAAGAAPVAREMFHAAFPPGTFKKTQEVNPQPKIGQEGTLEAR
>NZ_CP043041.1|WP_000599731.1|2824206_2824719_-|rod-shape-determining-protein-MreD
MILEKLVIAIGILIAHFLNGSNLFEIGSAIKPDFMILLVLFFALRRGPLYGLWIGFFGGLLTDSGLGGEISVGNVVTYKIGLHSLTFCLIGYLVGKFARSAYHENYLSITIYSLLITFITRLATYYLFSLFFHENMSYSLFFTSLFNALIAPAFFYALTWIYQLDHMGDA
>NZ_CP043041.1|WP_000964329.1|2824715_2825813_-|rod-shape-determining-protein-MreC
MLWFQLSRSKETLSLLFCILFSILSLTFRSNVIVRGIASFQRVGDVVSGSIDSFGGFFKGAYNKLESFETIRKERDSCVAVMEDYKLLPQDLEKANRENDALRKELKFHSRQKYSSLKAEVLSVRLNSIYRTIIIDKGSDSGIKPYMPVTARAVDQKGAIIEALVGKVIAVTGGSAVVQPLINSNFNMGISMPDTNLWANLSGNSGRGTEALLNYIDSGIIIDPRVFGEYPMGPSEMIQYTESLSKIGKPVYTSGGGGVFPSGIPVGIITEEGPRNGSFKSAYLKPFVRFEMLESVTILLKLPEKWLETWPEGQNITIENPYFGELNFPGEDRLKENQTKTPNTNQTQTNETKNQPSTPNEEDLQ

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Crispr_ID: NZ_CP043041_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_5

3056602-3056691

Orphan

Consensus_repeat	Method
CGTCTCACTTCTAAACTCAATGCATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043041_5

>merge|NZ_CP043041|5|3056602-3056691|CRISPRCasFinder
CGTCTCACTTCTAAACTCAATGCATCACTTTTAGAGTCGCTCTGTGGTCGTTCGGGAAACTCAGCGTCTCACTTTTAAACTCAATGCATC

>NZ_CP043041|5|5|3056602-3056691|CRISPRCasFinder
CGTCTCACTTCTAAACTCAATGCATC	ACTTTTAGAGTCGCTCTGTGGTCGTTCGGGAAACTCAG
CGTCTCACTTTTAAACTCAATGCATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_000150993.1\|3049254_3049578_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377300
NZ_CP043041.1\|WP_000615880.1\|3054136_3056068_+\|single-stranded-DNA-specific-exonuclease-RecJ	unknown	unknown	gnl\|CDD\|273193
NZ_CP043041.1\|WP_001122024.1\|3049654_3050821_+\|iron-containing-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|341486
NZ_CP043041.1\|WP_000850108.1\|3069698_3070295_+\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
NZ_CP043041.1\|WP_148636799.1\|3051835_3052558_+\|glycoside-hydrolase-family-25-protein	unknown	unknown	gnl\|CDD\|119375
NZ_CP043041.1\|WP_001170202.1\|3066951_3068322_+\|DUF389-domain-containing-protein	unknown	unknown	gnl\|CDD\|377221
NZ_CP043041.1\|WP_000670773.1\|3056743_3058207_-\|polynucleotide-adenylyltransferase-PcnB	unknown	unknown	gnl\|CDD\|130997
NZ_CP043041.1\|WP_000273875.1\|3047752_3048493_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001192262.1\|3043953_3045882_+\|NAD(+)-synthase	unknown	unknown	gnl\|CDD\|143594
NZ_CP043041.1\|WP_002187858.1\|3070457_3071828_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224429
NZ_CP043041.1\|WP_001083567.1\|3048489_3049242_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|381175
NZ_CP043041.1\|WP_000852854.1\|3069359_3069632_+\|DUF736-family-protein	unknown	unknown	gnl\|CDD\|133956
NZ_CP043041.1\|WP_002187963.1\|3061619_3062243_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP043041.1\|WP_001193516.1\|3069198_3069336_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000444199.1\|3063869_3066716_-\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP043041.1\|WP_000618030.1\|3050817_3051237_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000623627.1\|3046936_3047638_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001278842.1\|3053813_3054134_+\|polymer-forming-cytoskeletal-protein	unknown	unknown	gnl\|CDD\|377376
NZ_CP043041.1\|WP_000625244.1\|3058260_3059277_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP043041.1\|WP_000567061.1\|3059819_3060776_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|234599

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000615880.1\|3054136_3056068_+\|single-stranded-DNA-specific-exonuclease-RecJ	gnl\|CDD\|273193	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ. All proteins in this family are 5'-3' single-strand DNA exonucleases. These proteins are used in some aspects of mismatch repair, recombination, and recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	4.20612e-72
NZ_CP043041.1\|WP_000567061.1\|3059819_3060776_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	5.87493e-45
NZ_CP043041.1\|WP_000850108.1\|3069698_3070295_+\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	3.20225e-75
NZ_CP043041.1\|WP_148636799.1\|3051835_3052558_+\|glycoside-hydrolase-family-25-protein	gnl\|CDD\|119375	cd06413, GH25_muramidase_1, Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	3.95807e-116
NZ_CP043041.1\|WP_001170202.1\|3066951_3068322_+\|DUF389-domain-containing-protein	gnl\|CDD\|377221	pfam04087, DUF389, Domain of unknown function (DUF389). Family of hypothetical bacterial proteins with an undetermined function.	5.67518e-59
NZ_CP043041.1\|WP_000670773.1\|3056743_3058207_-\|polynucleotide-adenylyltransferase-PcnB	gnl\|CDD\|130997	TIGR01942, pcnB, poly(A) polymerase. This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).	2.20032e-95
NZ_CP043041.1\|WP_000150993.1\|3049254_3049578_+\|hypothetical-protein	gnl\|CDD\|377300	pfam04316, FlgM, Anti-sigma-28 factor, FlgM. FlgM binds and inhibits the activity of the transcription factor sigma 28. Inhibition of sigma 28 prevents the expression of genes from flagellar transcriptional class 3, which include genes for the filament and chemotaxis. Correctly assembled basal body-hook structures export FlgM, relieving inhibition of sigma 28 and allowing expression of class 3 genes. NMR studies show that free FlgM is mostly unfolded, which may facilitate its export. The C terminal half of FlgM adopts a tertiary structure when it binds to sigma 28. All mutations in FlgM that prevent sigma 28 inhibition affect the C-terminal domain and is the region thought to constitute the binding domain. A minimal binding domain has been identified between Glu 64 and Arg 88 in Salmonella typhimurium. The N-terminal portion remains unstructured and may be necessary for recognition by the export machinery.	0.00215375
NZ_CP043041.1\|WP_001192262.1\|3043953_3045882_+\|NAD(+)-synthase	gnl\|CDD\|143594	cd07570, GAT_Gln-NAD-synth, Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases). Glutamine-dependent NAD synthetases are bifunctional enzymes, which have an N-terminal GAT domain and a C-terminal NAD+ synthetase domain. The GAT domain is a glutaminase (EC 3.5.1.2) which hydrolyses L-glutamine to L-glutamate and ammonia. The ammonia is used by the NAD+ synthetase domain in the ATP-dependent amidation of nicotinic acid adenine dinucleotide. Glutamine aminotransferases are categorized depending on their active site residues into different unrelated classes. This class of GAT domain belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to classes 7 and 8. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase forms a homooctamer.	9.49099e-83
NZ_CP043041.1\|WP_002187858.1\|3070457_3071828_+\|hypothetical-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	4.30105e-47
NZ_CP043041.1\|WP_001083567.1\|3048489_3049242_+\|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase	gnl\|CDD\|381175	cd11648, RsmI, Ribosomal RNA small subunit methyltransferase I (RsmI), also known as rRNA (cytidine-2'-O-)-methyltransferase. RsmI is an S-AdoMet (S-adenosyl-L-methionine or SAM)-dependent methyltransferase responsible for the 2'-O-methylation of cytidine 1402 (C1402) at the P site of bacterial 16S rRNA. Another S-AdoMet-dependent methyltransferase, RsmH (not included in this family), is responsible for N4-methylation at C1402. These methylation reactions may occur at a late step during 30S assembly in the cell. The dimethyl modification is believed to be conserved in bacteria, may play a role in fine-tuning the shape and functions of the P-site to increase the translation fidelity, and has been shown for Staphylococcus aureus, to contribute to virulence in host animals by conferring resistance to oxidative stress.	4.63727e-101
NZ_CP043041.1\|WP_000852854.1\|3069359_3069632_+\|DUF736-family-protein	gnl\|CDD\|133956	PHA01740, PHA01740, putative single-stranded DNA-binding protein.	0.000329196
NZ_CP043041.1\|WP_002187963.1\|3061619_3062243_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.90657e-08
NZ_CP043041.1\|WP_000444199.1\|3063869_3066716_-\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	5.32309e-146
NZ_CP043041.1\|WP_001278842.1\|3053813_3054134_+\|polymer-forming-cytoskeletal-protein	gnl\|CDD\|377376	pfam04519, Bactofilin, Polymer-forming cytoskeletal. This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localization and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	1.96443e-27
NZ_CP043041.1\|WP_000625244.1\|3058260_3059277_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.85427e-40
NZ_CP043041.1\|WP_001122024.1\|3049654_3050821_+\|iron-containing-alcohol-dehydrogenase	gnl\|CDD\|341486	cd14864, Fe-ADH-like, iron-containing alcohol dehydrogenases (Fe-ADH)-like. This family contains iron-containing alcohol dehydrogenase (Fe-ADH) which catalyzes the reduction of acetaldehyde to alcohol with NADP as cofactor. Its activity requires iron ions. The protein structure represents a dehydroquinate synthase-like fold and is a member of the iron-activated alcohol dehydrogenase-like family. It is distinct from other alcohol dehydrogenases which contains different protein domains. Proteins of this family have not been characterized.	8.36121e-118

>NZ_CP043041.1|WP_000615880.1|3054136_3056068_+|single-stranded-DNA-specific-exonuclease-RecJ
MIQPSPFSHGPGLKELHPAGLRPHFSPLQHRFYETHLREKSHPEHLLYHGLRELPSPFLLPDLEPALDLLKEFIQKEKKILLFGDRDCDGVSSTSLLGSFLKKIHRGELILKTSNEEDYGLCPAALDFVKRIKPDLLITLDFGTTNHIQIDELASIGIKVIVLDHHEIPERIPDCYLISPKRSDSIYPNEKICTSVLALKFIQAYLYSSLEEYNRATWIGDGNSLFSGFLIYRGKLLFQGDRQEAESKFSLTIQDESYSFQSSYPEREWFYQEFLKYPAILEQYLQNFDLASIGTVSDMMPLYGENRIIVREGCKILFKLHKKETSHREGLFQLLQLMEFADNRVTSKDLGWGLGPMINSAGRMNRTDVALNLLLEENPELAKSGAKELQKLNEERKERTKRNIFKVDSFLKRKKERTERSVLFCYEPDFEPGVSGIVATRLVEEYKRPVLFITPDHGHAKGSIRAYGKENVLNLLKKAESVFLQFGGHKEAGGFSLEIDKIPELAKLIFDNADNWLAEEQMTSTSEQTESLISLKPEELNPKIFQELSIFEPFGHENPIPLYSIKNAKIYHTKPMTDGKHVRFRILGAPESIQCLIWNRGKDFLELISKSVSLDLWGSLEESTFRSKTSLQFIVNYFQESEN
>NZ_CP043041.1|WP_001278842.1|3053813_3054134_+|polymer-forming-cytoskeletal-protein
MSDEQIDTVIGDDIHFRGKLKFNNSLKIKGNFKGTIETTGKLVVGDTGEVEADIQTGTLEVEGNLKGNVSANQKVAIRKTGKVIGDIRTPDLEIESGAKFSGNSAM
>NZ_CP043041.1|WP_148636799.1|3051835_3052558_+|glycoside-hydrolase-family-25-protein
MKRKFLFFLLVIISFFLLGIGSYNALNSGKIWFVYPSTSQYPIRGIDVSNHQGKIDWTLVPKSEISFVYIKATEGRDFKDKSFHLNWKKAKANGFFVGAYHFFTLCKSGKEQAENFISTVPKEIDSLPPVVDLEFLGNCKERSSMKDVSNEIQEFLNRVDSHYGKKTILYLTYEFIDRYIGPNFQDHPIWIRDLFKHPNTFSNQRWILWQYKSRGNLPGISGPVDMNVLNGELKILTLTK
>NZ_CP043041.1|WP_000618030.1|3050817_3051237_-|hypothetical-protein
MIRHYAFLFLWLFGVSLILISGKQPNPYLVHVRKIPLPHAYPWEEVLTYCLLITVEILVLYWILRPKTYNLSWLRSLSGSLFFFILGGAHLFTLMHAPSYMLFHCMYLFCIGIMIFVFSMWALVNKNRFGSNSKESINP
>NZ_CP043041.1|WP_001122024.1|3049654_3050821_+|iron-containing-alcohol-dehydrogenase
MPILPDWVHYTFPPKIHFEADCGYKVGNFVKNIGSRTVIFSTQQELENMDELSVIKTSLEKHIDGVILYDDIAKEPSPEELDTAAYFAKIANADCIIGYGSYESISMAKLIALLITNDIFAEDMINDRKLKLKKPIPLILIPTHPVFGLECSPISTILLGDEKITRYFSHELLFPELIIADPKISSFMSSMDISKVGVGILAAAVDTILSKFSTELTISSALRAIELLQKNLIPSIRDPKNVNYKNGLYAASLLTGIAQSSSSLGLCFALSLASSNITNLDIFQSMSILLPHVMEYNLTSSAGKYVMIARALDEDITNISVIEAAIKAVEGIRKIFIELKIPQRLSEYEVRKMDLPSIANLAASFPFLDSLPRELPKNEIETILIAAF
>NZ_CP043041.1|WP_000150993.1|3049254_3049578_+|hypothetical-protein
MTIDKIGGIGGSGYEPKRTAPVKKTESKETFDNVSISDTAKQKASEAKLQAEIQTITRKILSTPDDQDRSVKLKEIKEKLKNGDYDNLSPEVLNTIADRISETMLGQ
>NZ_CP043041.1|WP_001083567.1|3048489_3049242_+|16S-rRNA-(cytidine(1402)-2'-O)-methyltransferase
MNSEEESSEIPLEPGTLYVVSTPIGNLEDLTFRALRILKNTDRILCENSGHSKKLFRSYSIHTQCSTLYKDQSENPYLSILEELKEGKTFALVSDAGTPGISDPGSHLIRVVREKGFKISPIPGPSALTALLGISGWQANPFLFLGFLSEKKGKKRNQLYEWKEFEGLIMIFESVHRIEDTLNSIQEVFSDCEFLIGREMTKIHEEILHFSPFATEKSKEFASKGEFVVLINTNRKKMLKGSIGSADRIQ
>NZ_CP043041.1|WP_000273875.1|3047752_3048493_+|hypothetical-protein
MYFQIFRSTSLPILTFIWILFGCGMNTDVAQSPFIFISPVGVPQFLSILAVNEGITDTATKDTDFQSEPNSYKPEFLVRYYVTNAEPQFVGYNLYITTAAPSVAETLTSGNVYLENGVQPSFPHLASEASTSSSKLQTHRVLNQIPPPGVFPFIKCEIYTFTMRALLNSGIFSNPSTPVKMCSSSRPFLCPVGSSCNPAECNNSSCTTAVKQNCPVGTLCNPCTISGSEETGCICPTGVSPPGCNL
>NZ_CP043041.1|WP_000623627.1|3046936_3047638_-|hypothetical-protein
MISIRKLVIYSGISISLIVLVWILFSSEDSSEKERKSKEADSVALLLGGGGSSSPSSGSSGGKTNESIFDSSFYKSGKGEYIESDKGEPKEADPNAADADNPVNPQTNKPYTNEEMERFSQLRERFPDNSLIPKKLSPAEKEAKRQEDSRIAEAARNVFARTATHDQIRSYYQNMEKQTQDRMDIINYLVDLQKGSGEEETEKKLNNIQESIKNQLQQVQKEKENAFKQAGIL
>NZ_CP043041.1|WP_001192262.1|3043953_3045882_+|NAD(+)-synthase
MQSVRLTSVSLKTKVFDFQGNLEKIKRVLELEKKSDLILFPELCISGYGCEDAFYFPRIWKKSWNSLIQLLPHTENKIIVVGLPIFQNPYLFNCAAVLCNGVVAGIVPKSNLASTGVHYENRWFTRGEESQENFIAPDGSTIPFGSLIFETDHFSFGVEICEDSWVLQKPSIPLAEAGTDLILSPGASHFAFGKQRIRRQIFQESSRRESNVYLFSNLCGNESGRLIFEGGSMIVQNGKLLSESERLFFGDFSLCSNEIDFEASQADRAKNFRPSGNRFSKTKSTEENKIYLGIEFPKRAPKVNKSLLEISVSKEEESYLDFTKAVALGLFDYLMYSNTKGYTLSLSGGADSSACALLVTAMKKIAKLELGENFFKSKGIPEESILCTLYQSTSNNSDRTKFLAKSLAKEIQSIHGDLTIDSEIQSISEKISKLTGISLRWDEHNLTLQNIQARVRSPIIWMLANLNGHLLLSTGNRSEASVGYTTMDGDSSGSIAPLTGVSKEFILKWLRFVSEGKDPILPAYPSIKEIVNSPPSAELKPPEDKQEDEKDLMPYPLLQKIEELFIVRGAGYSEIIQLLSEDSEIQNLPPRFLEESVKKYISLFHKNQWKRERLPPSFHLDDYGLDPKSSFRFPILSENIEL
>NZ_CP043041.1|WP_000670773.1|3056743_3058207_-|polynucleotide-adenylyltransferase-PcnB
MKFLSNLFKKKIGSVEDILSHPDGKRYYRDAHLIRKNMIDEDAVKIIHRLNKFGFKAYIVGGGVRDLLLGRKPKDFDVVTNATPNQIKKIFNNCRIIGRRFKIVHILFRGKVIEVSTFRSLPDYRLGKAVEDQDYLIKRDNKFGTPQEDAARRDFTINSLYYDVRNDSIIDYVGGFEDIRNKVLRVIGDPDISFREDPVRMLRAVKFAEILGLNIEKTTAKAIRKHKTELEKASSSRMLEEYNKIFRTWKTSLIFQGMAEHGILEVLFKEAFDKERKKNSNFGEKFLETNIGKRLAIADKLLTEREEMTPHIFYSLIFSDLASEALQKENMHLVPAIKNSLELIFRRLETPKKDKDRLIKIFASQQRFLSTEDEKSSQNNFFRMKDYFYDAFMVFKIGAIAENDEKAIQSAFFWEISVRKRPTPVKKFNGARPNKSRNRNFQKNREEDRSNRREETQSSSESEKQNRKNQKENSQEDFSSEDSGNEF
>NZ_CP043041.1|WP_000625244.1|3058260_3059277_+|M23-family-metallopeptidase
MISPAKYDLKLTHSERLQVKILKFKNRFRKFKESGSKKISFLLVPHSHENVITIELNVFMAWFLGILSGLILILAFLFLSYLNFFYRPDQDLFQKSDENVSQYLYYDMLLQDAKKEIRGLERKTEQLNLVAWDEVPWKRILTYEVIPEFHLKKEIPDSETNLELYKNTVEGFAVQNIELFRIRQAFENAFDYLEERESILYALPRGRPLKPGVGFVSSTFGGRVDPFGLVILGEHHSGVDFASAEGTPIYATAPGVVVESGQSSGGLGRNIKINHLNGIFTVYGHCSQILVEKNQIVKRGDLIGLVGSTGKATGPHVHYEVHIGQDPPLDPAEFINIE
>NZ_CP043041.1|WP_000567061.1|3059819_3060776_+|prolipoprotein-diacylglyceryl-transferase
MIDRIPVPFLNPLFKFLFNREWDGPSTFSILMMIGFLTASYLLPKELKRRKLEPEHSDWLLLLGILGTLVGAKIFFVFEIWDQIFVETPGFDGKYIYPLTHWYGFPGRMSLWDNLFSGSGLVFYGGFLFGILFITLYMKYFQLDIASYLDAAVPSMAIGYAIGRLGCWVSGDGCYGFATNVEIPLLVFNYHGAHPSGVPVWNTPLIESIISFLFFFYFQFWARNQNFKKFSIGAQYLVLHGFARLLVEFLRVNKAVFPLMDPPAFVNIPNAEQNPEFLTQYYWHGFSQSQLVSIIIILVGAFFILKWKLWKKENTSNI
>NZ_CP043041.1|WP_002187963.1|3061619_3062243_-|class-I-SAM-dependent-methyltransferase
MSDPWTDRWNERYNKEEFAFGEQPNEYLKEQLEKLKIGTILFPAEGEGRNAVFAAKLGWNVSAFDISIEGKKKAFRLAEANQVKIDYQVGELQTLDYHSEQFDAIALIYAHFPAEIKSYYHKTLSQYLRKDGLVILEAFSKKHIHYVLKNEKVGGPRELEMLFSIDEIKSDFENYEIIELEEKEIELKEGLFHNGNGSVIRFVGRKR
>NZ_CP043041.1|WP_000444199.1|3063869_3066716_-|DNA-translocase-FtsK
MESKPKEFKPTWNLQNGKMILPYVLLFAGIILTLSLGSFDAGERGVEYNFFGRLGYYISYGMFFMFGAASFLPGLFTIGLGSLRLVKEEFELTNRLFSIPVFLLCYTVTLQVTGHVSTIPFASQGGFVGQLLSSGLEFVFGSTGKILIHLVFYFYGLILLLNESPLHFIGRILGTAGAKYKEGFKSGFGKRGESLGSLFQSAVEKFQKKESVPPWISTNTNEKNSLNQSYSLSNPHTHSYERNLGNKQPSELQNTLHSTFGKEGKLSDFLSKVDTGPTVTSKNSRIRFQNHGAFSGNFEEQGKVFRFESVSSSLSEKIREEKNFQKTPSRWEILDFRTSSFSNIISEKEPSVTLVVPSESEIKKEWNQTNPILQSEEIPDKFLFEEKEKVEQTDSGLENECYEEESVDSEENLSEEETLSSETSTEKDISENFKTSTISNSKEVSPNHTSNSSIHSLEKSEEKLELGLPFPPTTLVPEVKSKRSIYHVPLKSLKTTTTKIQDPLFKIEADKVARKIEEIIRQYGYESQVVSMERGPIITRYELTPPLGVKLGRITSLSDELRLYLAVKNIRIVAPIPGKSTIGIEVPNSIREDVFLGDILHQNLSLRPKKDLSILIGKDISGKLVGIDLNKLPHLLVAGTTGSGKSVCLNSMISSLVVHLSPEEVRFIMIDPKMVELTLYEDIPHLLMPVITDPKKATRALAWAIQEMEARYHSVSKLKCRDFKTYNEKVEQGAHRDGYKKMPYIVIFIDELADLMMVSGKDLEDAITRITQKSRAVGIHLIMATQRPSVDVITGLIKANCPARMAFHVAQKTDSKIILDQNGAESLLGKGDFLYKSPTAADLIRIQSPYVSEEEIEKIVEEARKFGKPSYVDFNLDEETESSVVDEGDEELFEQAWEIVRTDRKASASYLQRRMRIGYNKAARLMELMEERGYVSPQIGSKGREILK
>NZ_CP043041.1|WP_001170202.1|3066951_3068322_+|DUF389-domain-containing-protein
MQKKSSHNPEPNFWDLLAPLFEFINPLLHIRNDTDETGTIESIKRGVNFSGSALWTLIFAIFIASIGLNINSTAVIIGAMLISPLMGPIMGAGLALGIYDFELLKKSLRNLAVMTFLSLFTSALYFLISPLSDAQSELLARTSPTIYDVLIAFIGGATGIVAGSRKDKISNAIPGVAIATALMPPLCTAGYGLANWNFKFFLGAFYLYLINSVFIGISTLIFVRYLKFQRTVYTDPAVDKKIYRYVYLLSVCLILPSIYFAYDIVVDSAFKRNAKSYLENQFTFEKSKILSANIVRKGGEKKIEVTMIGETLSEDVLSQLKTILPKYGLEDTELKIIQSYRDSSQLNQQSGFSFQNEAGSKIQEEKIHLLENELRILKDKDHLAQSVAKEINVLFPSVDSFSLGDFLVQNVQDFSSSKEVTVLVKWKHQVGSIERKRLELFLKLRLGLENLQVLDL
>NZ_CP043041.1|WP_001193516.1|3069198_3069336_+|hypothetical-protein
MQTITTEWMNERIEILAEILADQLIEEIRKRALEKEKLPNQTEAA
>NZ_CP043041.1|WP_000852854.1|3069359_3069632_+|DUF736-family-protein
MAEYTLKEKKGSLFSNAAKEKETQPDYTGKVLLEGKTYRLAGWIRKSATGKNYLSLSLSEPNLEKKSEGSSVITVTDGNDFTDIEEDFPF
>NZ_CP043041.1|WP_000850108.1|3069698_3070295_+|LemA-family-protein
MKTKIDFKLFLITTLTLLVFSNCGYNTIQEEDEAINASWAEILNQYQRRSDLIPNLVNTVKGYATQEEKVLIAVTKARAGVGSIQADEKTLNNPELFKKYSQAQAQMTSALSKLLVIAENYPELKSNANFRDLQAQLEGTENRITVARNRYIQAVQKYNVTIRKFPNNLTAKFFGFETKPSFSVENEKEISKPPEVKF
>NZ_CP043041.1|WP_002187858.1|3070457_3071828_+|hypothetical-protein
MNLLKARMIQSVTIKILFSVCLLVCTAGIHLKIGNSHSTFIIEEWKAEDQIIPLLRSPVTDATFTLTKEQKVQLTNRLISFETKKGSQIAVLIVGSTGEWSIEEYALKVFEKTKLGRKGIDDGILIVVAIQDHKTKIEVGYGLEGTIPDAIAKRIIEEFMIPHFKNGDYFQGVSDGIDTLILKIDGEELPETNKIPKFFEVINKYSMYIFPSLILIILIITIFITSGIFGTIVLIGGGFFLILMLESIILLVIIFFPLIFFFLMASHLRKKIRIRRKSFITPTNWDYIIIAVFIILGIVSTIGLIGFGIFRGLISESTILGISILILLIFFFLMTGYLRKKIQRKSFWDYIIIAVFIILGIVSTIGLVGFGIFRGLISESMILGIPLILIFLIMGYLRDKIRRKSFWDYILFGTGTSSSGSSSRSSWGSSGSSSSGGSSWSGGGGSSGGGGASGSW

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Crispr_ID: NZ_CP043041_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_6

3230776-3231605

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT

11 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_6

>merge|NZ_CP043041|6|3230776-3231605|PILER-CR,CRISPRCasFinder,CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCCAGCGGGATTCTTGGAAATAAATTACTCAACAAACTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTAAATCGGAAGCATGTTGCGACTCGATTTCGAAATCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACACTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTAACAACATAGTCTTTAGAGATAGAGGCCATGACAAGCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACACATACTAATTTTTGATCCAACTGTTGTTGTGTTAATCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTATCGTTATCCGCCAAGGCGTTATCAGTTCTACAATCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACTTAACAACCATATCTGTAGTCTTATATGCAATTTTCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACATCGGAATATTTGCCCCTTTTGTATCATAGTCGTAACTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP043041|6|1|3230776-3231532|PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCAGCGGGATTCTTGGAAATAAATTACTCAACAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTAAATCGGAAGCATGTTGCGACTCGATTTCGAAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TAACAACATAGTCTTTAGAGATAGAGGCCATGACAAG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACATACTAATTTTTGATCCAACTGTTGTTGTGTTAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATCGTTATCCGCCAAGGCGTTATCAGTTCTACAAT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTAACAACCATATCTGTAGTCTTATATGCAATTTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC

>NZ_CP043041|6|6|3230776-3231605|CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCAGCGGGATTCTTGGAAATAAATTACTCAACAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTAAATCGGAAGCATGTTGCGACTCGATTTCGAAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TAACAACATAGTCTTTAGAGATAGAGGCCATGACAAG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACATACTAATTTTTGATCCAACTGTTGTTGTGTTAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATCGTTATCCGCCAAGGCGTTATCAGTTCTACAAT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTAACAACCATATCTGTAGTCTTATATGCAATTTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	ATCGGAATATTTGCCCCTTTTGTATCATAGTCGTAA
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP043041|6|1|3230776-3231604|CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCAGCGGGATTCTTGGAAATAAATTACTCAACAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTAAATCGGAAGCATGTTGCGACTCGATTTCGAAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAATATTCATGGCGCCTTGTCTCCCTGGGCTTCACA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTTGGACAACAACTTCCTCGCTCCCCGCATGTTCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TAACAACATAGTCTTTAGAGATAGAGGCCATGACAAG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACATACTAATTTTTGATCCAACTGTTGTTGTGTTAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACAAAAAAAGACAAGTTGGTCCGGAATGCGTTTGGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAGAGTGGCGTGAATTTTTGCATGAGTTGACCCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATCGTTATCCGCCAAGGCGTTATCAGTTCTACAAT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTAACAACCATATCTGTAGTCTTATATGCAATTTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	ATCGGAATATTTGCCCCTTTTGTATCATAGTCGTAA
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_025177715.1\|3223873_3224080_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001110347.1\|3224465_3225017_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101

>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001110347.1|3224465_3225017_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP043041.1|WP_025177715.1|3223873_3224080_+|hypothetical-protein
MVLCNKIAEGIDTRNIGESVLLSFKRDLSSANRRETLSLRERSMAFKLDYIELAVLSLPLWYSIYKDQ
>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM

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Crispr_ID: NZ_CP043041_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_8

3232099-3232206

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_8

>merge|NZ_CP043041|8|3232099-3232206|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACCAACGTTTCGCGGGACCTTGATTCCTTCGGAGCGACTGAATATAACTTTGATGCCGGTAGGCGATTTAGATG

>NZ_CP043041|8|8|3232099-3232206|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	CAACGTTTCGCGGGACCTTGATTCCTTCGGAGCGA
CTGAATATAACTTTGATGCCGGTAGGCGATTTAGATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001110347.1\|3224465_3225017_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001110347.1|3224465_3225017_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI

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Crispr_ID: NZ_CP043041_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_9

3232361-3232468

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_9

>merge|NZ_CP043041|9|3232361-3232468|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACAGCGTTTCTAATTTTTCGTCTACAGTCACTTTACGCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP043041|9|9|3232361-3232468|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	AGCGTTTCTAATTTTTCGTCTACAGTCACTTTACG
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001110347.1\|3224465_3225017_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001110347.1|3224465_3225017_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI

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Crispr_ID: NZ_CP043041_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_10

3232625-3232732

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_10

>merge|NZ_CP043041|10|3232625-3232732|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACCTTCAAAACACGATGCTCCCCGGAGTCGCTGGAACTTGAATATAACTTTGATGCCGTTAGGCGATTTAGAAT

>NZ_CP043041|10|10|3232625-3232732|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	CTTCAAAACACGATGCTCCCCGGAGTCGCTGGAAC
TTGAATATAACTTTGATGCCGTTAGGCGATTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001110347.1\|3224465_3225017_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001110347.1|3224465_3225017_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP043041_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_7

3231761-3231941

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

2 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_7

>merge|NZ_CP043041|7|3231761-3231941|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGGTAGGCGTTGAGCACTTGGTTCTTTTGTATATTTAAAACGACTTACAGTTTCTGAATATAACTTTGATGCCATTAGGCGTTGAGCACATTTCTGCATCCTCTTTTTCGTTCAGTTTCCACAGCCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP043041|7|7|3231761-3231941|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGGTAGGCGTTGAGCAC	TTGGTTCTTTTGTATATTTAAAACGACTTACAGTTT
CTGAATATAACTTTGATGCCATTAGGCGTTGAGCAC	ATTTCTGCATCCTCTTTTTCGTTCAGTTTCCACAGC
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_025177715.1\|3223873_3224080_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001110347.1\|3224465_3225017_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001110347.1|3224465_3225017_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP043041.1|WP_025177715.1|3223873_3224080_+|hypothetical-protein
MVLCNKIAEGIDTRNIGESVLLSFKRDLSSANRRETLSLRERSMAFKLDYIELAVLSLPLWYSIYKDQ
>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP043041_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_11

3232889-3233212

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACAC	PILER-CR

4 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_11

>merge|NZ_CP043041|11|3232889-3233212|CRISPRCasFinder,PILER-CR
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACTGCGAAATAGAAGAACTTTTGATGTTTGATATAAAGCTGAATATAACTTTGATGCCGATAGGCGTTGAGCACACGGACCAACCAGGTATAAAACTCCAACAGATTACCCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACACGGACCAACCAGGTATAAAACTCCAACAGATTACCCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACCCACGAAACAGATACAAAGCCTTCTATTTTTCCCTCTGAATATAACTTTGATGCCGGTAGGCGGTTTAGATG

>NZ_CP043041|11|11|3232889-3233212|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TGCGAAATAGAAGAACTTTTGATGTTTGATATAAAG
CTGAATATAACTTTGATGCCGATAGGCGTTGAGCAC	ACGGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	ACGGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	CCACGAAACAGATACAAAGCCTTCTATTTTTCCCT
CTGAATATAACTTTGATGCCGGTAGGCGGTTTAGATG

>NZ_CP043041|11|2|3232961-3233142|PILER-CR
CTGAATATAACTTTGATGCCGATAGGCGTTGAGCACAC	GGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACAC	GGACCAACCAGGTATAAAACTCCAACAGATTACC
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP043041.1\|WP_002188754.1\|3246643_3246826_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001110347.1\|3224465_3225017_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001110347.1|3224465_3225017_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP043041.1|WP_002188754.1|3246643_3246826_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP043041_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_12

3233370-3233477

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_12

>merge|NZ_CP043041|12|3233370-3233477|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACTGTCAGTGACGGCGAATTTCATGAGCCTGCATTTTCTGAATATAACTTTGATGTCGTTAGGCGGTTTAGAAT

>NZ_CP043041|12|12|3233370-3233477|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TGTCAGTGACGGCGAATTTCATGAGCCTGCATTTT
CTGAATATAACTTTGATGTCGTTAGGCGGTTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP043041.1\|WP_002188754.1\|3246643_3246826_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001110347.1\|3224465_3225017_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001110347.1|3224465_3225017_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIGIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP043041.1|WP_002188754.1|3246643_3246826_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP043041_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_14

3233856-3233963

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_14

>merge|NZ_CP043041|14|3233856-3233963|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCACCTTCAAAACACGATGCTCCCCGGAGTCGCTGGAACCTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP043041|14|14|3233856-3233963|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCAC	CTTCAAAACACGATGCTCCCCGGAGTCGCTGGAAC
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188754.1\|3246643_3246826_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP043041.1|WP_002188754.1|3246643_3246826_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP043041_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_13

3233589-3233699

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_13

>merge|NZ_CP043041|13|3233589-3233699|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCACAGCGTACTAGGTCGTGAATCACTTACTGGGGCTGAAAACTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

>NZ_CP043041|13|13|3233589-3233699|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCAC	AGCGTACTAGGTCGTGAATCACTTACTGGGGCTGAAAA
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188754.1\|3246643_3246826_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP043041.1|WP_002188754.1|3246643_3246826_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP043041_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_15

3234120-3234440

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR

4 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_15

>merge|NZ_CP043041|15|3234120-3234440|CRISPRCasFinder,CRT,PILER-CR
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACGAATAACTCGTTCGGAAAGCGTTCTGCGGATCTTCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACTTGATCGAAAGTCTTCGAATATTAAAATCCGATCCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGACAGAATATTAAAAACGAAAGAACAAGAAATCTTGCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTGATCACGACCGGGACTTTGATTGCTGTAGCTATCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP043041|15|15|3234120-3234440|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	GAATAACTCGTTCGGAAAGCGTTCTGCGGATCTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTGATCACGACCGGGACTTTGATTGCTGTAGCTAT
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP043041|15|2|3234120-3234439|CRT
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	GAATAACTCGTTCGGAAAGCGTTCTGCGGATCTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTGATCACGACCGGGACTTTGATTGCTGTAGCTAT
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAA

>NZ_CP043041|15|3|3234190-3234368|PILER-CR
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188754.1\|3246643_3246826_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP043041.1|WP_002188754.1|3246643_3246826_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP043041_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_16

3234598-3234922

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR

4 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_16

>merge|NZ_CP043041|16|3234598-3234922|CRISPRCasFinder,CRT,PILER-CR
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACTTATACGACGAGAGCGAGGTGGCGGCTCTGTTACGCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCATTTTTGCTCTTCCTTAATATTCATTTTGTTTACTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACACTTAAGACCAAATCGTAACGTCTGGTTTGAGACTCTGAATATAACTTTGATGCCGTTAGGCGATTTAGACA

>NZ_CP043041|16|16|3234598-3234922|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TTATACGACGAGAGCGAGGTGGCGGCTCTGTTACGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CATTTTTGCTCTTCCTTAATATTCATTTTGTTTACT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACTTAAGACCAAATCGTAACGTCTGGTTTGAGACT
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGACA

>NZ_CP043041|16|3|3234598-3234921|CRT
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	TTATACGACGAGAGCGAGGTGGCGGCTCTGTTACGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CATTTTTGCTCTTCCTTAATATTCATTTTGTTTACT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ACTTAAGACCAAATCGTAACGTCTGGTTTGAGACT
CTGAATATAACTTTGATGCCGTTAGGCGATTTAGAC

>NZ_CP043041|16|4|3234670-3234850|PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCAAATTGAGTTTTAGGATTTCTGCTACAATATCTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CATTTTTGCTCTTCCTTAATATTCATTTTGTTTACT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188754.1\|3246643_3246826_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP043041.1|WP_002188754.1|3246643_3246826_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP043041_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_17

3235079-3235258

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

2 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP043041_17

>merge|NZ_CP043041|17|3235079-3235258|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCACAGTTAATCAAAAAGATTCTGAGTATTTTAGAAGAGCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACGGTTCGAAGGCGCTAAGGCTTGGATGAAAGCGCTCGGCTGAATATAACTTTGATGCCGGTAGGCGATTTAGGA

>NZ_CP043041|17|17|3235079-3235258|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGTTAGGCGTTGAGCAC	AGTTAATCAAAAAGATTCTGAGTATTTTAGAAGAG
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	GGTTCGAAGGCGCTAAGGCTTGGATGAAAGCGCTCGG
CTGAATATAACTTTGATGCCGGTAGGCGATTTAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_002188749.1\|3231620_3231854_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_001072139.1\|3225359_3225746_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP043041.1\|WP_139343776.1\|3233209_3233401_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP043041.1\|WP_000110275.1\|3230529_3230733_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_002188754.1\|3246643_3246826_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP043041.1\|WP_042709572.1\|3227451_3227736_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_033108617.1\|3242860_3243079_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000451411.1\|3225929_3226142_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000601700.1\|3236744_3239003_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	6.70445e-45
NZ_CP043041.1\|WP_001140542.1\|3246222_3246651_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP043041.1\|WP_002188751.1\|3228499_3230125_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0
NZ_CP043041.1\|WP_000683530.1\|3230124_3230409_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	8.42665e-19
NZ_CP043041.1\|WP_000026902.1\|3236115_3236748_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	5.38787e-102
NZ_CP043041.1\|WP_000371343.1\|3241812_3242436_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.03879e-101
NZ_CP043041.1\|WP_000578381.1\|3226403_3227279_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.000758652
NZ_CP043041.1\|WP_000235348.1\|3244751_3245921_+\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	4.55987e-28
NZ_CP043041.1\|WP_002188755.1\|3240952_3241792_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	4.15083e-83
NZ_CP043041.1\|WP_000098750.1\|3239004_3240888_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.73817e-164
NZ_CP043041.1\|WP_080010676.1\|3227811_3228021_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	5.55155e-11
NZ_CP043041.1\|WP_001216977.1\|3235439_3235835_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41

>NZ_CP043041.1|WP_139343776.1|3233209_3233401_+|hypothetical-protein
MRRRFVLIAIAPYKGHKRIKCRNSCFSEKQYFVQRNVGTPTLKKRGFLRLLSQTYKNRDAVRR
>NZ_CP043041.1|WP_002188749.1|3231620_3231854_-|hypothetical-protein
MASKLYSETVSRFKYTKEPSAQRLPAPDFCKFDLRDAETFFFQSGSSHIYLNKAQFFGKVVVPTFYLFARLVRNNLG
>NZ_CP043041.1|WP_000110275.1|3230529_3230733_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP043041.1|WP_000683530.1|3230124_3230409_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP043041.1|WP_002188751.1|3228499_3230125_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADNRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP043041.1|WP_080010676.1|3227811_3228021_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVSQDKIQLGIPIIGLLKPHKTLYSRLIGSANI
>NZ_CP043041.1|WP_042709572.1|3227451_3227736_+|hypothetical-protein
MGNRFDYKANETNLRDWFIIHACKKSHHRNLLGYTGKEHPEYLLAKRKNRFRITISERSFSKNKPFSLHCNLSESQSPGLLYLAVNRFISNSIL
>NZ_CP043041.1|WP_000578381.1|3226403_3227279_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGEYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEEWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP043041.1|WP_000451411.1|3225929_3226142_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKVWTTALGNVNKL
>NZ_CP043041.1|WP_001072139.1|3225359_3225746_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVFFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP043041.1|WP_001216977.1|3235439_3235835_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP043041.1|WP_000026902.1|3236115_3236748_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPALHEHDSLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP043041.1|WP_000601700.1|3236744_3239003_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWTRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNARIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSKIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSLNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGAFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEGIAQVLIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWNLN
>NZ_CP043041.1|WP_000098750.1|3239004_3240888_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLPECTSPLLRAGLAGLYSTLYSLKDEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRSKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVEEKKIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKESRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP043041.1|WP_002188755.1|3240952_3241792_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGYDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFSGIKAAVEDAKKRIGKSA
>NZ_CP043041.1|WP_000371343.1|3241812_3242436_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHRKFFSSCEMCSAVADSNPARSTVLRRMRRLGDSRRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPMKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP043041.1|WP_033108617.1|3242860_3243079_-|hypothetical-protein
MQSIRIPGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERNKSYIQLNPL
>NZ_CP043041.1|WP_000235348.1|3244751_3245921_+|IS110-family-transposase
MATQQSRPRIGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLTQYGLM
>NZ_CP043041.1|WP_001140542.1|3246222_3246651_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP043041.1|WP_002188754.1|3246643_3246826_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFLAMILKKALKFLLSFVSRSLVSKANSNLVFFLK

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Crispr_ID: NZ_CP043041_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043041_18

3700492-3700606

Orphan

Consensus_repeat	Method
AATAGAGTAGTTGAAAAATAAATTCTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043041_18

>merge|NZ_CP043041|18|3700492-3700606|CRISPRCasFinder
AATAGAGTAGTTGAAAAATAAATTCTCCTATCTGTTTCTATTTTATGGAAACGGTCGATTGAAATAGTTTTGTTAATCCCGCTATAGAATAGAGTAGTTGAAAAATTAATTCTCC

>NZ_CP043041|18|18|3700492-3700606|CRISPRCasFinder
AATAGAGTAGTTGAAAAATAAATTCTCC	TATCTGTTTCTATTTTATGGAAACGGTCGATTGAAATAGTTTTGTTAATCCCGCTATAG
AATAGAGTAGTTGAAAAATTAATTCTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043041.1\|WP_000570773.1\|3692626_3693157_-\|SET-domain-containing-protein	unknown	unknown	gnl\|CDD\|380940
NZ_CP043041.1\|WP_082269134.1\|3707963_3708209_-\|DUF1563-domain-containing-protein	unknown	unknown	gnl\|CDD\|203693
NZ_CP043041.1\|WP_000183410.1\|3699798_3700425_+\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|198303
NZ_CP043041.1\|WP_000681097.1\|3703640_3703934_-\|metal-sensing-transcriptional-repressor	unknown	unknown	gnl\|CDD\|197387
NZ_CP043041.1\|WP_000688306.1\|3694012_3694846_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP043041.1\|WP_001220692.1\|3716199_3717579_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|367035
NZ_CP043041.1\|WP_000684307.1\|3694842_3696099_-\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|225459
NZ_CP043041.1\|WP_000395815.1\|3692009_3692609_+\|DUF2179-domain-containing-protein	unknown	unknown	gnl\|CDD\|235234
NZ_CP043041.1\|WP_000952672.1\|3713117_3716234_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|226220
NZ_CP043041.1\|WP_060589296.1\|3705883_3707782_-\|DUF1561-domain-containing-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP043041.1\|WP_000738676.1\|3709720_3710641_+\|lipase	unknown	unknown	gnl\|CDD\|224001
NZ_CP043041.1\|WP_112120693.1\|3711172_3712315_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
NZ_CP043041.1\|WP_000481668.1\|3696832_3697426_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|376578
NZ_CP043041.1\|WP_002189487.1\|3704306_3705248_-\|DUF1561-family-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP043041.1\|WP_001008156.1\|3696095_3696341_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043041.1\|WP_001054065.1\|3691150_3691951_+\|MCE-family-protein	unknown	unknown	gnl\|CDD\|367096
NZ_CP043041.1\|WP_002189443.1\|3701206_3703426_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP043041.1\|WP_000659126.1\|3703422_3703623_-\|copper-resistance-protein-CopZ	unknown	unknown	gnl\|CDD\|225127
NZ_CP043041.1\|WP_000391357.1\|3697485_3698211_-\|PAS-domain-S-box-protein	unknown	unknown	gnl\|CDD\|131984
NZ_CP043041.1\|WP_001125095.1\|3698469_3698910_+\|GyrI-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|214874

Protein	Function_ID	Function_description	E-value
NZ_CP043041.1\|WP_000570773.1\|3692626_3693157_-\|SET-domain-containing-protein	gnl\|CDD\|380940	cd10542, SET_SUV39H, SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins. This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.	2.782e-17
NZ_CP043041.1\|WP_082269134.1\|3707963_3708209_-\|DUF1563-domain-containing-protein	gnl\|CDD\|203693	pfam07599, DUF1563, Protein of unknown function (DUF1563). A small family of short hypothetical proteins in Leptospira interrogans.	2.8686e-15
NZ_CP043041.1\|WP_000183410.1\|3699798_3700425_+\|glutathione-S-transferase-family-protein	gnl\|CDD\|198303	cd03194, GST_C_3, C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	4.8177e-58
NZ_CP043041.1\|WP_000681097.1\|3703640_3703934_-\|metal-sensing-transcriptional-repressor	gnl\|CDD\|197387	cd10152, SaCsoR-like_DUF156, Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156. This domain family includes Staphylococcus aureus CsoR (SaCsoR). SaCsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis; it represses a genetically unlinked copA-copZ operon. copA encodes a copper efflux P-type ATPase, and copZ, a copper chaperone. This family belongs to a larger superfamily that contains various transcriptional regulators that respond to different stressors such as Cu(I), Ni(I), sulfite, and formaldehyde, and includes Mycobacterium tuberculosis CsoR (MtCsoR), Bacillus subtilis CsoR, and Thermus thermophilus CsoR. The latter three proteins do not belong to this family. CsoRs form homotetramers (dimer of dimers). In MtCsoR, within each dimer, two Cys residues on opposite subunits, along with a His residue, bind the Cu(I) ion (forming a triagonal S2N coordination complex, C-H-C). These residues are conserved in the majority of members of this superfamily, including this family, and a conserved Tyr and a Glu residue that facilitate allosteric regulation of DNA binding for CsoRs are also well conserved.	3.95318e-36
NZ_CP043041.1\|WP_000688306.1\|3694012_3694846_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	3.72642e-09
NZ_CP043041.1\|WP_001220692.1\|3716199_3717579_-\|TolC-family-protein	gnl\|CDD\|367035	pfam02321, OEP, Outer membrane efflux protein. The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.	4.25217e-17
NZ_CP043041.1\|WP_000684307.1\|3694842_3696099_-\|NAD(P)-binding-protein	gnl\|CDD\|225459	COG2907, COG2907, Predicted NAD/FAD-binding protein [General function prediction only].	3.58781e-53
NZ_CP043041.1\|WP_000395815.1\|3692009_3692609_+\|DUF2179-domain-containing-protein	gnl\|CDD\|235234	PRK04164, PRK04164, hypothetical protein; Provisional.	1.78122e-75
NZ_CP043041.1\|WP_000952672.1\|3713117_3716234_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|226220	COG3696, COG3696, Putative silver efflux pump [Inorganic ion transport and metabolism].	0
NZ_CP043041.1\|WP_060589296.1\|3705883_3707782_-\|DUF1561-domain-containing-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	0
NZ_CP043041.1\|WP_000738676.1\|3709720_3710641_+\|lipase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	2.75616e-17
NZ_CP043041.1\|WP_112120693.1\|3711172_3712315_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	2.99529e-28
NZ_CP043041.1\|WP_000481668.1\|3696832_3697426_+\|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl\|CDD\|376578	pfam01625, PMSR, Peptide methionine sulfoxide reductase. This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.	9.9266e-88
NZ_CP043041.1\|WP_002189487.1\|3704306_3705248_-\|DUF1561-family-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	2.38695e-163
NZ_CP043041.1\|WP_001054065.1\|3691150_3691951_+\|MCE-family-protein	gnl\|CDD\|367096	pfam02470, MlaD, MlaD protein. This family of proteins contains MlaD, which is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane. The family also contains the mce (mammalian cell entry) proteins from Mycobacterium tuberculosis. The archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage. This family contains proteins of unknown function from other bacteria.	4.90451e-13
NZ_CP043041.1\|WP_002189443.1\|3701206_3703426_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP043041.1\|WP_000659126.1\|3703422_3703623_-\|copper-resistance-protein-CopZ	gnl\|CDD\|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	4.56214e-08
NZ_CP043041.1\|WP_000391357.1\|3697485_3698211_-\|PAS-domain-S-box-protein	gnl\|CDD\|131984	TIGR02938, Nitrogen_fixation_regulatory_protein, nitrogen fixation negative regulator NifL. NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions].	3.2675e-12
NZ_CP043041.1\|WP_001125095.1\|3698469_3698910_+\|GyrI-like-domain-containing-protein	gnl\|CDD\|214874	smart00871, AraC_E_bind, Bacterial transcription activator, effector binding domain. This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.	1.26846e-17

>NZ_CP043041.1|WP_000183410.1|3699798_3700425_+|glutathione-S-transferase-family-protein
MTNLQLVIGDKKLSSWSMRPWILLKEKNIPFIEISLTLNTPEFYEKIKLYSNASKVPVLIDGDIKIWDTNSIVEYLAETFPEKNLWPKDKTLRAIARSIVAEMHSGFSDLRKNLPMKIIERLYGKSFPEEVWKDIQRIESIWKDCLNLYQGPFLFGKEFTIADAFYTPVVGRFITYGIELDSEANKYVSTISGLHSYKEWIEEALKSK
>NZ_CP043041.1|WP_001125095.1|3698469_3698910_+|GyrI-like-domain-containing-protein
MPKKYLIGIGTRTKNENEMGSNGNIPKLWEKFFGEVLPKLKTTDKFIYAVYKDYESDENGEYSYFIGVPSDEINIFETVQLPEGKYLELTSLKGKSPNIVIELWQKVWTNSDIKRRRAFEVDYEIYPIDFSETPETQVHLLLSVKD
>NZ_CP043041.1|WP_000391357.1|3697485_3698211_-|PAS-domain-S-box-protein
MEEIYVYDESKNRGGKEMMNLSSILVSYFYQYPHAMFITNRCGMIEYINPVFETLSGYSRSELIGQNPKLFQAGVHDPNFYEELWKTILSGKEYEGNFLNRNGSGETIAWKERITPLRDEAGNISNFLCRVDLSSKDEVSAVPTEEQSMPVENFQNTKVKESLFPQLQREYGLTCQEAKICERLVAGQTRACLIQQLGVHSGTLKNHLKAIYRKTIEKDLPQPGQGRDKLQRLTMFLIRLC
>NZ_CP043041.1|WP_000481668.1|3696832_3697426_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MFNFKILIFIYIIFFSPNLMATPKTEKATFAGGCFWCMEGPFESLPGVISVVAGYSGGKEFYPTYQEVSRGKTGHRESVQIEFDSSKIRYEELLTVFWNQIDPTDNGGQFADRGNQYRTGIFYHNQTQKKAAEKSKREISESKKFPGSIVVEIIPFTSFYPAEDYHQNYYKTNSEQYKKYKKYSGREDYLEKMCRQR
>NZ_CP043041.1|WP_001008156.1|3696095_3696341_-|hypothetical-protein
MNEYLLSSDKYFIQKNVCKRIEIISQVKKEHQTYTPTKGLKFSLRIDSIIKKSFERINMIFILKEKNPMFSFQKSKIKNQI
>NZ_CP043041.1|WP_000684307.1|3694842_3696099_-|NAD(P)-binding-protein
MKIAILGSGIAGLSACWYLSKEHDVILIERHSLPGMDAHGTDISLKDGVFRFDVPFRAFKQNYYPCLIEMYNEAGIEFRPVDYSFSLSERDGTTYFQFATIGIGGNFYPFVSPVCFKNGESRKIFSDTIRFYGESAKQLESLRGEQLTISGFLQRFGYSKEFENKYLIPMFATINTCTILSAKNYPAEAVIRYHSKGLKFLRFLTASHGTKDITEKLSIGAKELRLKTNPRKIEQNGKKVFVSFDDGKEEFDRVIIATPANQAISLLPDEMAPEKELLSSFHYEESEILMHTDPSFMPNKKRHWAPLCFTLSPETDKPSATIRLNKVLPEIGKVEIFQTWNPLEEPKRGTLISRSRFERPIIDLKNQKTVEKLKALQEQPGRKIWFCGSYARYGIPLLEAGVSTSLDVKRWVENSERF
>NZ_CP043041.1|WP_000688306.1|3694012_3694846_+|class-I-SAM-dependent-methyltransferase
MKIFFKKKRIEAPDTLAHLYLNPKNSSWANFGYWKDTTDYPTACKELALLLGRKADLKPGLKVLDLGFGCGDQFFVWKEKFSLNFSDLVGVNGSFVQTEFAKKLIESKSNVSPKLICSSVEKAILSFPHQSLDRILCLDSASFFSDRIEFCKQAFKILKPGGKLVSAELILKNSKLGMIDSWFRKMICKSGSIPKNNRVTPDSLSQLLRSSGFLLEGFDFLEKYIFEGFSNFLKMKSKESSIPKEISRKYSYFAEFLGGERMKKYFQFVLYSAVKPD
>NZ_CP043041.1|WP_000570773.1|3692626_3693157_-|SET-domain-containing-protein
MIEKRINKFGENGTFATKDIPKGTLLFSYSEWIEDEEFGWKVLTVEEAESLPDSEKDIFMKYGYDVDFGLVTGPTSDQYVINHSNFMNHSCDPNMWYDQDDNIVAKRDIRAGEELTIDYANFIVNFDQTFECGCGSVNCRKFIRKDDWKLLVNEYQMNFPKFIQKEIKKLYVKIPV
>NZ_CP043041.1|WP_000395815.1|3692009_3692609_+|DUF2179-domain-containing-protein
MEFSFPLPGNPIFDYVLLPCFIFLSRVTDVSIGTIRVILLTREKKGIAASLGFLEVLLWVVVITQVIKNLNNVFCYLAYAGGFATGTFIGMILEEKLAIGFSLLRIISPQNGSEIADKLSEAGYRVTIMNGHGSRGPVKIVFTVLKRKKIDQAMKIVQNVEPDVFYSIENARRTNTTTFEDSPGLLRRGILEKILKIRK
>NZ_CP043041.1|WP_001054065.1|3691150_3691951_+|MCE-family-protein
MNLSKHTAVLTGIVFFLAFSLSMYVSVIEKAGTKDEYPYTMKIYYPRLEGIHPGAPVRILGVEKGIVRSLDVVPIDEVEDQRFLNKDQTKAIEIIVRLKEPITLWDNYKITFQTNTILSGRTIDIDPGSFDKEETSFFQPTYLEEEQKSPDFLPSADYFEDFFAASTGVIRENREDIRTSFNNFYEISEKLKSNRGTIPQIINSPETYDNVIELLTDARIFGNDARRYLEGNRKLERSAPIPLTINMYRRTTLIGNVSNRYYFGKL
>NZ_CP043041.1|WP_002189443.1|3701206_3703426_-|copper-translocating-P-type-ATPase
MKVQQELHLNEVTLDVIGMTCANCALRIEKGLKKIPGVKDVRVNFAMETAKIDFESSISKEILMDKIDFLGYRAVVHEDIQIDGEIQKKEFKKLKVRVIVSAFLSLPLLLSMIGHFENNLNFEYLSFLMNPWLQFILATPIQFWIGASFYKGSFRALRNGGANMDVLVVLGTSAAYFYSVYLTFIFNEKYIHKTANLYYETSSVLITLILFGKLLEHIVKGKSSKAIQSLVNLQPKKANVIREKEIQEIPLLAVRSGDLILVKPGESIPVDGIIEEGSSTIDESMLTGESIPVEKTISNFVYGGSLNQNGTFKFRALKVGKETLLSGIIRAVREAQGTKAPIQRIADQISEIFVPVIVLISVITLCVWYFWILPSTFSVALEKAIAVLVVACPCALGLATPISVLTGSGKAATMGILFRSAEALEILHKVNAIVFDKTGTLTYGKLVLKSLESLNIAKENNLLTLAASAEQNSEHPLSKAIVESAKKKGLVLAIPENFETIPGGGISAIVEGNRILIGTERLFYAKGIELNQELNNLKRIREEEGNTVVHLSVNEIHSAILTLADTLKESTPATIAKLKSLGIEVYMITGDNERTARVISKDCGIERVLAEVLPEKKAMEVKNLKSLGKVVSMVGDGINDAPALAISDLGIAMGTGTDVAMESSDLVIVNGDLNSIVNAITISRKTVYNIRQNFFWALLYNTLGIPIAAAGFLAPWVAGGAMALSSVSVVLNALRLQRD
>NZ_CP043041.1|WP_000659126.1|3703422_3703623_-|copper-resistance-protein-CopZ
MKEIRLTVEGMTCLHCLKTIESALKEAGFTGKANLENREVVYYGKGTTEELSKVKETILKKGYKPE
>NZ_CP043041.1|WP_000681097.1|3703640_3703934_-|metal-sensing-transcriptional-repressor
MKHKPKHKLISDPKESKNLILRLKKIEGQIRGIQGMIENEKYCDDVLNQISSVKSALDGVSRGLLKSHIRTCVTERIRENDSKILEEFMTTVGYILR
>NZ_CP043041.1|WP_002189487.1|3704306_3705248_-|DUF1561-family-protein
MGRWIVLLLVLLISLGVGYSYGVNPDQYCPASKKENHNIRIKRTLPPNFQLTEEWLRRLYDIATSASLTEGQIHGICGVCLLQTFQMLAELQEYHSHGPLQSGGYFFNTAPDTDPFDSFRQRYPELDTMLTDAATAYGPAYNTTRLLTLVSAMTMMPQYEWTPSREFTTRSDMHSHIRSLIDSPPGSIWLGLMQRRESDETLRWHALPILRTSQGLIVIQTRVSTMSFELYRLYLTPSTSIVQIINDYLEEADRTLTVLVTIQLEQAYQNLFDFMVSNMNCTGEGENRRGSGGYPTSATVNQCSGGRCALPNW
>NZ_CP043041.1|WP_060589296.1|3705883_3707782_-|DUF1561-domain-containing-protein
MGRWIVLLLVLLISFGVGYSYGVNPDVVPISSSDIPGSIIQRPTDKPKDKPIKVNVSSGGTFCYGPNFSGGESYIVIEQCWQMHVMNARYDVFQRISYNINDTWLCITVSESVVKGETNWDYVHLRPCTINDPLQRWIVKENSFWTADERYRLKDTNWYAYISRNSGDRYNHTLDSSMSDWINTVATPGNISILTSIAWDLGSDRYFIRSGGSDKNTTPIYYNPESGHLAQYNPVSGLLSCMYSRVGSYDWNWVTWALCSDAPISKDNPAYWNVYLATEEGGMIMDYQGNALRVTRYGPNWGVAYAAKLSYLKKDTTYNPTSLFIVDRNLLNWVRYTVSNLGKTDQYCPAGKKENHNIRIKRTLPPDFQLTEEWLRRLYDIAISTSFTSEGQVHGICGTCLLQTFQMLAELQEYHSHGPIQGGGYFFNTAHDRDPFDSFRQRYPELDAMLVNIPIVYSQDGNVPRMGLASARTMLPQYDWTLSREFTTRSEMLSHITSLIASPPGSMWLSMFRVRRPDGTTGGHAVPILRTSQGLVVIPTNSASLSFFTYRRFATPTTDPVQVMNNLEMSSWTLEILVTAQLEGLYYNTFDFTISNRNCTGEGRDRRGSGGYPTRTTVNQCSGRGGGRCVLL
>NZ_CP043041.1|WP_082269134.1|3707963_3708209_-|DUF1563-domain-containing-protein
MNIILIGFFLLETLENLYATYVEYFLKQTFLDSIQKISKMDQKQNEIPVLPIFKILIFQVISSKGIFLNLSDNKIYQRYKL
>NZ_CP043041.1|WP_000738676.1|3709720_3710641_+|lipase
MKKMNLKILLTLVFLITNVTYASGGGTSSKPLSGSYPIVLAHGLFGWGNGSTVVDYWGGNAAYLRNQGAYVLTPSVTALNSSSSRASQLKTSILAAMAANNYTGKVHIIGHSQGGLDARYMVSNLSMSTKVATLTTLNTPHQGSPIANIVAAVIPNWALPYVSTVLNTIIGFVYGDSSQNAISALKLLTTDGLKTFNSVTPNVSGVKYFSYGSTISVPDLIQHPAMGILHPICAIGAPFYGMSIANDGVVPDSSQRWGTWKGGPSIPILTTGIDHLEATNALYLGQLWYDTNAYFLKMANNAKSNQ
>NZ_CP043041.1|WP_112120693.1|3711172_3712315_-|IS110-family-transposase
MGVLVLSPDFVKSFRLFHFRRKEMESQEVKYVGVDCGKKSIEVVRINSENSLERRQFSTTESGINNLLQWLTLNDIVGLEAGSQSFRIAKSILNKGVQVIVLNPGNLATIYQSLKKTDKEDSLKIARLIQRHPIEELPTVPIPNDEEEDNRRLCSEHENWTKQLTQGKNRLHSLFTQAGLTQITKKHLRTKVSREASVTLLSDRYKKEAERILKVLDLVELNLKLIEEEIQEALKKNKAYVQTIMSMPGIGMITSLAIMSYMGDCKRFSSAKQAAYYAGLVPRVDISGDTVRYGRIINRGCHSIRRVIVQAAWSLVRCQHGGKVKEFYQRLYLKKGAKKSIIATSRKMIEVLYVMIRTGKLFDSMPENILNRKLAQYGLM
>NZ_CP043041.1|WP_000952672.1|3713117_3716234_-|efflux-RND-transporter-permease-subunit
MLSRLLNISLSNPILSTGTVFFLFIYSFFTLKDVPIDAVPDITNTQVIVIAKTGSLDPEQVEKVVTFPLETELMGMPNLIDVRSVSKFGLSNISLIFKEGTDIYQARSMVLERISSAQEKLPKGISPTIVPNTTGLGEIFFYTVEAKQGSKLASLPEKERLLYLRTVQDYTVRPQIKALVPGIVEVDSNGGYEKEIHIDLNPNKMKFWGITIDQLIGELSTIGESFGGGFIENDGKLAIVRAYGIKKSLNSLSEVTVRRTLTGSPIRVSDIAEVKEHGKQRLGGASSEGKEIVLGTAMMLRGENSFQVNSDLNRAVSLLKLPEDVQVRILLERSFLIHSTILTVTKNLSEGAVLVILTLFFILYNIKASIIVAAIIPGSMLLTAIFMKVFGISANLMSLGAIDFGLLVDASIVITENVLTRFERDAIFSREEKIRTILNASLEVLKPVSFGIVVIMLVYVPIFTLDGIPGKMFRPMAQTVLFALGFSLILAVFFLPPLLFFFITPPKRIVNQEVKKSRIVILYETYLPVLLKKPKLIIIGSILFFLLTLFIYFRMGTVFLPKLMEGDLMLVIVREGDISIEESLKEQKEVEKLLMQMPEIQSVFSRIGTSSVANDPMGTFNADTFIILKKESLNDLLEEKNWENLLNRIHKKVQESFPKSELTLSQPLEARFNELLEGSRADISVRILGKDLNTLLDLQNSLKDILHNIPGAAEVELDPIMALRKSTVVDIIPDPFKLKYYNISLPLFNSAVESSMSGFELGGYYEEEVRFPIKIWLSEEFRNHESEISNIGIGTEDGGMIPIKLLASIEKKEKIMTISRNKSRRFVAVSVNLRGRDLEGFYSEAKDKISNMNIPQGYSVFWGGQIENLSKAKDKLSVILPSTFLMIFVVLYLGLKSVRRALLVFFCVPFALTGGIWLLFLRGMDLSVSAFVGCIALSGISVLNGLVKLDTIHRIREKEKISLRDAVLKGATSRIRPVIMTALVASFGFMPMAFGSGLGSEVQKPLATVVIGGIVSSTILTLVILPVFYYWLEDDFKN
>NZ_CP043041.1|WP_001220692.1|3716199_3717579_-|TolC-family-protein
MRIKRDHLPENYKSIFYFLKLFLILMKNVADDFLNLPILFNTIFFLAILVCPVRSENSSQLDVRTILDKAEKNSPLLLSLNADLESLFYQRKQQGKTQNPSLTLDYGRRSAANESGSEYALQFEQPVYFPGRKELHQLLVDNDSKIKEIQLQEANNSIRFNALKFAYRYLVSAGKKNHVKERLKRLSILESYIRARPFITPQSKTDLFIIQRKILALRKHFNDLELDANKQYEAMNLYLMLESVPSFRIPFFTEGVKFNFNELLNKAVSQNLTLMAAKGEIEKAKTELNLASLEKYPDYSIISQVGEDRSGVANRFYDFGFKFRIPVWDRFQNKISAAEVNVKSKQEIFRHQENLVKTAFKQAFLDYEQSKINLKLFNLSKLDEIEKDLIYADVEFKKGRILMISYLELENQLHETHHAILDAQIAHLEALLNLLYITNEKEIIGTLQHAVQTFEYQLK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_CP043041_3	3.1\|2796558\|46\|NZ_CP043041\|CRISPRCasFinder	2796558-2796603	46	NZ_CP043041.1	989860-989905	1.0
NZ_CP043041_3	3.1\|2796558\|46\|NZ_CP043041\|CRISPRCasFinder	2796558-2796603	46	NZ_CP043041.1	2769137-2769182	1.0
NZ_CP043041_3	3.1\|2796558\|46\|NZ_CP043041\|CRISPRCasFinder	2796558-2796603	46	NZ_CP043041.1	3511756-3511801	1.0
NZ_CP043041_3	3.1\|2796558\|46\|NZ_CP043041\|CRISPRCasFinder	2796558-2796603	46	NZ_CP043041.1	2890092-2890137	1.0
NZ_CP043041_3	3.1\|2796558\|46\|NZ_CP043041\|CRISPRCasFinder	2796558-2796603	46	NZ_CP043041.1	2890163-2890208	1.0
NZ_CP043041_3	3.1\|2796558\|46\|NZ_CP043041\|CRISPRCasFinder	2796558-2796603	46	NZ_CP043041.1	4072106-4072151	1.0
NZ_CP043041_3	3.1\|2796558\|46\|NZ_CP043041\|CRISPRCasFinder	2796558-2796603	46	NZ_CP043041.1	4072176-4072221	1.0

1. spacer 3.1|2796558|46|NZ_CP043041|CRISPRCasFinder matches to position: 989860-989905, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

2. spacer 3.1|2796558|46|NZ_CP043041|CRISPRCasFinder matches to position: 2769137-2769182, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

3. spacer 3.1|2796558|46|NZ_CP043041|CRISPRCasFinder matches to position: 3511756-3511801, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

4. spacer 3.1|2796558|46|NZ_CP043041|CRISPRCasFinder matches to position: 2890092-2890137, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

5. spacer 3.1|2796558|46|NZ_CP043041|CRISPRCasFinder matches to position: 2890163-2890208, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

6. spacer 3.1|2796558|46|NZ_CP043041|CRISPRCasFinder matches to position: 4072106-4072151, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

7. spacer 3.1|2796558|46|NZ_CP043041|CRISPRCasFinder matches to position: 4072176-4072221, mismatch: 0, identity: 1.0

aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	CRISPR spacer
aacgcgacctgcagagcgacccttagggagcgatgcattgagtttg	Protospacer
**********************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP043041_6	6.4\|3231028\|36\|NZ_CP043041\|PILER-CR,CRISPRCasFinder,CRT	3231028-3231063	36	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	821-856	0	1.0
NZ_CP043041_6	6.5\|3231100\|37\|NZ_CP043041\|PILER-CR,CRISPRCasFinder,CRT	3231100-3231136	37	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	53283-53319	0	1.0
NZ_CP043041_6	6.6\|3231173\|37\|NZ_CP043041\|PILER-CR,CRISPRCasFinder,CRT	3231173-3231209	37	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	50052-50088	0	1.0
NZ_CP043041_17	17.1\|3235115\|35\|NZ_CP043041\|CRISPRCasFinder	3235115-3235149	35	NZ_CP040842	Leptospira weilii strain CUDO6 plasmid pDO6, complete sequence	54220-54254	0	1.0
NZ_CP043041_17	17.1\|3235115\|35\|NZ_CP043041\|CRISPRCasFinder	3235115-3235149	35	NZ_CP040845	Leptospira weilii strain CUD13 plasmid pD13, complete sequence	60471-60505	0	1.0
NZ_CP043041_11	11.4\|3233141\|35\|NZ_CP043041\|CRISPRCasFinder	3233141-3233175	35	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	7368-7402	1	0.971
NZ_CP043041_13	13.1\|3233625\|38\|NZ_CP043041\|CRISPRCasFinder	3233625-3233662	38	NZ_CP039286	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL3, complete sequence	66415-66452	1	0.974
NZ_CP043041_16	16.2\|3234706\|37\|NZ_CP043041\|CRISPRCasFinder,CRT,PILER-CR	3234706-3234742	37	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	6936-6972	1	0.973
NZ_CP043041_8	8.1\|3232135\|35\|NZ_CP043041\|CRISPRCasFinder	3232135-3232169	35	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	25961-25995	3	0.914
NZ_CP043041_8	8.1\|3232135\|35\|NZ_CP043041\|CRISPRCasFinder	3232135-3232169	35	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	54324-54358	3	0.914
NZ_CP043041_6	6.2\|3230883\|36\|NZ_CP043041\|PILER-CR,CRISPRCasFinder,CRT	3230883-3230918	36	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	52974-53009	5	0.861
NZ_CP043041_6	6.2\|3230883\|36\|NZ_CP043041\|PILER-CR,CRISPRCasFinder,CRT	3230883-3230918	36	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	27310-27345	5	0.861
NZ_CP043041_6	6.10\|3231462\|35\|NZ_CP043041\|PILER-CR,CRISPRCasFinder,CRT	3231462-3231496	35	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	2876-2910	6	0.829
NZ_CP043041_17	17.1\|3235115\|35\|NZ_CP043041\|CRISPRCasFinder	3235115-3235149	35	HQ633071	Synechococcus phage S-SKS1 genomic sequence	140881-140915	7	0.8
NZ_CP043041_17	17.1\|3235115\|35\|NZ_CP043041\|CRISPRCasFinder	3235115-3235149	35	NC_017791	Deinococcus gobiensis I-0 plasmid P2, complete sequence	98983-99017	8	0.771
NZ_CP043041_16	16.3\|3234779\|36\|NZ_CP043041\|CRISPRCasFinder,CRT,PILER-CR	3234779-3234814	36	MG675557	Pseudoalteromonas phage Maelstrom, complete genome	1991-2026	9	0.75
NZ_CP043041_11	11.1\|3232925\|36\|NZ_CP043041\|CRISPRCasFinder	3232925-3232960	36	NC_011777	Bacillus cereus AH820 plasmid pAH820_272, complete sequence	22200-22235	10	0.722

1. spacer 6.4|3231028|36|NZ_CP043041|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 0, identity: 1.0

ttttggacaacaacttcctcgctccccgcatgttct	CRISPR spacer
ttttggacaacaacttcctcgctccccgcatgttct	Protospacer
************************************

2. spacer 6.5|3231100|37|NZ_CP043041|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 0, identity: 1.0

taacaacatagtctttagagatagaggccatgacaag	CRISPR spacer
taacaacatagtctttagagatagaggccatgacaag	Protospacer
*************************************

3. spacer 6.6|3231173|37|NZ_CP043041|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 0, identity: 1.0

acatactaatttttgatccaactgttgttgtgttaat	CRISPR spacer
acatactaatttttgatccaactgttgttgtgttaat	Protospacer
*************************************

4. spacer 17.1|3235115|35|NZ_CP043041|CRISPRCasFinder matches to NZ_CP040842 (Leptospira weilii strain CUDO6 plasmid pDO6, complete sequence) position: , mismatch: 0, identity: 1.0

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
agttaatcaaaaagattctgagtattttagaagag	Protospacer
***********************************

5. spacer 17.1|3235115|35|NZ_CP043041|CRISPRCasFinder matches to NZ_CP040845 (Leptospira weilii strain CUD13 plasmid pD13, complete sequence) position: , mismatch: 0, identity: 1.0

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
agttaatcaaaaagattctgagtattttagaagag	Protospacer
***********************************

6. spacer 11.4|3233141|35|NZ_CP043041|CRISPRCasFinder matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.971

ccacgaaacagatacaaagccttctatttttccct	CRISPR spacer
ccacgagacagatacaaagccttctatttttccct	Protospacer
******.****************************

7. spacer 13.1|3233625|38|NZ_CP043041|CRISPRCasFinder matches to NZ_CP039286 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL3, complete sequence) position: , mismatch: 1, identity: 0.974

agcgtactaggtcgtgaatcacttactggggctgaaaa	CRISPR spacer
agcgtactaagtcgtgaatcacttactggggctgaaaa	Protospacer
*********.****************************

8. spacer 16.2|3234706|37|NZ_CP043041|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.973

gcaaattgagttttaggatttctgctacaatatcttt	CRISPR spacer
gcaaattgagctttaggatttctgctacaatatcttt	Protospacer
**********.**************************

9. spacer 8.1|3232135|35|NZ_CP043041|CRISPRCasFinder matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 3, identity: 0.914

caacgtttcgcgggaccttgattccttcggagcga	CRISPR spacer
ccgtgtttcgcgggaccttgattccttcggagcga	Protospacer
* ..*******************************

10. spacer 8.1|3232135|35|NZ_CP043041|CRISPRCasFinder matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 3, identity: 0.914

caacgtttcgcgggaccttgattccttcggagcga	CRISPR spacer
ccgtgtttcgcgggaccttgattccttcggagcga	Protospacer
* ..*******************************

11. spacer 6.2|3230883|36|NZ_CP043041|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 5, identity: 0.861

ttaaatcggaagcatgttgcgactcgatttcgaaat	CRISPR spacer
ttaaatcggaagcatgttgcgactcgattccgtggg	Protospacer
*****************************.** ..

12. spacer 6.2|3230883|36|NZ_CP043041|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 5, identity: 0.861

ttaaatcggaagcatgttgcgactcgatttcgaaat	CRISPR spacer
ttaaatcggaagcatgttgcgactcgattccgtggg	Protospacer
*****************************.** ..

13. spacer 6.10|3231462|35|NZ_CP043041|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 6, identity: 0.829

ttaacaaccatatctgtagtcttatatgcaatttt	CRISPR spacer
ttaacaaccatatctgtagtcttatattttgtata	Protospacer
*************************** . .* *

14. spacer 17.1|3235115|35|NZ_CP043041|CRISPRCasFinder matches to HQ633071 (Synechococcus phage S-SKS1 genomic sequence) position: , mismatch: 7, identity: 0.8

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
atttaaatctaaagattctgaatatttttgaagag	Protospacer
* **** .  ***********.****** ******

15. spacer 17.1|3235115|35|NZ_CP043041|CRISPRCasFinder matches to NC_017791 (Deinococcus gobiensis I-0 plasmid P2, complete sequence) position: , mismatch: 8, identity: 0.771

agttaatcaaaaagattctgagtattttagaagag	CRISPR spacer
tttggtttaaaaagattcagagtattttagaggag	Protospacer
  * . *.********** ************.***

16. spacer 16.3|3234779|36|NZ_CP043041|CRISPRCasFinder,CRT,PILER-CR matches to MG675557 (Pseudoalteromonas phage Maelstrom, complete genome) position: , mismatch: 9, identity: 0.75

catttttgctcttccttaatattcattttgtttact	CRISPR spacer
tctttttgctcttcgttcatattcatttcatccaat	Protospacer
. ************ ** **********..*..* *

17. spacer 11.1|3232925|36|NZ_CP043041|CRISPRCasFinder matches to NC_011777 (Bacillus cereus AH820 plasmid pAH820_272, complete sequence) position: , mismatch: 10, identity: 0.722

------tgcgaaatagaagaacttttgatgtttgatataaag	CRISPR spacer
atcatttgt------gaataacttttgatgtttgatattaat	Protospacer
      **.      *** ******************* **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 9054

Bacillus_virus(50.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000695821.1\|1204_2326_+	DNA polymerase III subunit beta	NA	NA	NA	NA
WP_002189217.1\|2987_4085_+	DNA replication/repair protein RecF	NA	NA	NA	NA
WP_000654338.1\|4081_4546_+	DUF721 domain-containing protein	NA	NA	NA	NA
WP_148636666.1\|4611_6531_+	DNA topoisomerase (ATP-hydrolyzing) subunit B	G3M9Z3	Bacillus_virus	3.2e-138	44.4
WP_000076847.1\|6549_9054_+	DNA gyrase subunit A	A0A172JHV7	Bacillus_phage	2.2e-110	37.9

DBSCAN-SWA_2

24656 : 32816

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002095657.1\|24656_25013_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	3.6e-19	50.5
WP_000932791.1\|26112_27126_+	flagellar motor switch protein FliG	NA	NA	NA	NA
WP_148636670.1\|27190_29467_+	adenylate/guanylate cyclase domain-containing protein	M1HLN3	Pelagibacter_phage	1.9e-12	26.0
WP_060589199.1\|30155_30713_+	hypothetical protein	NA	NA	NA	NA
WP_082280699.1\|30690_31887_+	hypothetical protein	NA	NA	NA	NA
WP_000348685.1\|32111_32816_+	hypothetical protein	A0A1B1IVR4	uncultured_Mediterranean_phage	4.3e-24	42.0

DBSCAN-SWA_3

39845 : 57164

Lactococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001022131.1\|39845_42101_+	VacB/RNase II family 3'-5' exoribonuclease	Q0GXV6	Lactococcus_phage	5.2e-63	32.9
WP_000443328.1\|42272_42773_+	hypothetical protein	NA	NA	NA	NA
WP_000508949.1\|42776_44390_+	GMC family oxidoreductase	A0A1V0SI18	Klosneuvirus	5.6e-11	22.6
WP_000885539.1\|44531_46040_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_001076098.1\|46250_46955_-	type I 3-dehydroquinate dehydratase	NA	NA	NA	NA
WP_000371240.1\|46958_47927_-	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	1.5e-35	33.6
WP_000572205.1\|47910_48450_-	UpxY family transcription antiterminator	NA	NA	NA	NA
WP_000114031.1\|48433_48913_-	hypothetical protein	NA	NA	NA	NA
WP_001230742.1\|49994_51692_+	methyl-accepting chemotaxis protein	A0A1B0V854	Salmonella_phage	3.5e-35	43.6
WP_000528194.1\|52296_53175_+	M50 family metallopeptidase	NA	NA	NA	NA
WP_000744700.1\|53171_54110_+	SDR family oxidoreductase	A0A2K9KZK0	Tupanvirus	5.1e-89	50.2
WP_001020567.1\|54183_55353_+	Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha	NA	NA	NA	NA
WP_000565586.1\|55311_55848_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_002189237.1\|55844_57164_-\|tRNA	histidine--tRNA ligase	A0A1V0S921	Catovirus	8.0e-64	33.2

DBSCAN-SWA_4

64449 : 65358

Synechococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033108072.1\|64449_65358_+	septal ring lytic transglycosylase RlpA family protein	F5B3X9	Synechococcus_phage	9.5e-16	48.3

DBSCAN-SWA_5

82316 : 82838

Halovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000604072.1\|82316_82838_-	dCTP deaminase	R4T945	Halovirus	8.4e-17	37.4

DBSCAN-SWA_6

108984 : 114651

Catovirus(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000277636.1\|108984_111036_-	long-chain fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	4.1e-14	22.7
WP_000443346.1\|111214_111598_-	hypothetical protein	NA	NA	NA	NA
WP_002079613.1\|111570_112230_-\|tRNA	leucyl/phenylalanyl-tRNA--protein transferase	NA	NA	NA	NA
WP_001258728.1\|112279_112828_-	RNA 2',3'-cyclic phosphodiesterase	NA	NA	NA	NA
WP_002095654.1\|112875_114651_-	aminodeoxychorismate synthase component I	S4VT78	Pandoravirus	3.0e-37	28.6

DBSCAN-SWA_7

119697 : 120762

Pseudomonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000567183.1\|119697_120762_-	peptide chain release factor 1	A0A0S4KWG0	Pseudomonas_phage	9.5e-07	40.3

DBSCAN-SWA_8

137279 : 138998

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000446864.1\|137279_138998_-	GHKL domain-containing protein	W8CYF6	Bacillus_phage	1.5e-09	35.7

DBSCAN-SWA_9

158824 : 160645

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000828456.1\|158824_160645_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	1.8e-50	31.8

DBSCAN-SWA_10

165980 : 167123

Pandoravirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001141234.1\|165980_167123_+	chorismate synthase	A0A291AU41	Pandoravirus	5.1e-99	52.6

DBSCAN-SWA_11

228229 : 229195

Cafeteria_roenbergensis_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000649923.1\|228229_229195_+	NAD-dependent epimerase/dehydratase family protein	E3T4Y8	Cafeteria_roenbergensis_virus	1.8e-20	33.0

DBSCAN-SWA_12

241492 : 254591

Staphylococcus_phage(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001148871.1\|241492_243085_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	1.0e-153	52.7
WP_000691571.1\|243684_243912_-	hypothetical protein	NA	NA	NA	NA
WP_001049440.1\|243919_244660_-	hypothetical protein	NA	NA	NA	NA
WP_001074436.1\|244696_245491_-	hypothetical protein	NA	NA	NA	NA
WP_000809563.1\|245483_246260_-	ParA family protein	A0A240F4U1	Ochrobactrum_phage	2.4e-20	29.0
WP_000807224.1\|246373_247834_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_001150499.1\|249192_252702_+	DNA polymerase III subunit alpha	A0A291AVA6	Streptomyces_phage	2.1e-212	37.3
WP_000387038.1\|253739_254591_-	M23 family metallopeptidase	U5PY92	Bacillus_phage	1.1e-10	35.7

DBSCAN-SWA_13

265064 : 265742

Planktothrix_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000052667.1\|265064_265742_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.4e-26	34.8

DBSCAN-SWA_14

272020 : 273454

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001245092.1\|272020_273454_+	hypothetical protein	S5WIY5	Leptospira_phage	3.8e-35	27.0

DBSCAN-SWA_15

279859 : 281041

Erysipelothrix_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000804174.1\|279859_281041_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	5.5e-48	32.4

DBSCAN-SWA_16

291194 : 291743

Sinorhizobium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000872605.1\|291194_291743_+	NUDIX hydrolase	A0A0F6YPF5	Sinorhizobium_phage	7.8e-05	36.7

DBSCAN-SWA_17

306483 : 308604

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000102023.1\|306483_308604_-	elongation factor G	D0R0F5	Streptococcus_phage	1.6e-58	27.1

DBSCAN-SWA_18

318783 : 323258

Megavirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001189850.1\|318783_319806_+	zinc-binding dehydrogenase	A0A2P1EIJ9	Megavirus	5.3e-07	26.6
WP_002070306.1\|320127_321069_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_000090417.1\|321049_321829_+	TlyA family rRNA (cytidine-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000529870.1\|322031_323258_+	acyltransferase	B5WZU0	Pseudomonas_phage	3.4e-08	26.3

DBSCAN-SWA_19

328082 : 328811

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001088969.1\|328082_328811_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	3.3e-35	40.7

DBSCAN-SWA_20

333421 : 334393

Lactobacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002070132.1\|333421_334393_-	glycerophosphoryl diester phosphodiesterase	A0A075KJS1	Lactobacillus_phage	7.3e-14	25.4

DBSCAN-SWA_21

348016 : 350911

Prochlorococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001089340.1\|348016_350911_-	aminomethyl-transferring glycine dehydrogenase	M4QFZ1	Prochlorococcus_phage	5.1e-273	52.3

DBSCAN-SWA_22

356367 : 357495

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000612200.1\|356367_357495_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	2.2e-86	44.1

DBSCAN-SWA_23

381457 : 383998

Enterobacteria_phage(100.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000889239.1\|381457_383998_-\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	7.3e-122	33.5

DBSCAN-SWA_24

394378 : 395293

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001288326.1\|394378_395293_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.9e-27	35.8

DBSCAN-SWA_25

408706 : 409402

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060589209.1\|408706_409402_+	SAM-dependent methyltransferase	W8CYT3	Bacillus_phage	6.4e-12	36.6

DBSCAN-SWA_26

415420 : 420568

Leptospira_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189254.1\|415420_416863_-	hypothetical protein	S5WIY5	Leptospira_phage	1.1e-05	32.8
WP_001046558.1\|417582_418824_-	hypothetical protein	NA	NA	NA	NA
WP_002189379.1\|419017_420568_-	hypothetical protein	A0A2P1ELB3	Moumouvirus	1.6e-15	23.7

DBSCAN-SWA_27

442682 : 444578

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189384.1\|442682_444578_+	ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	3.4e-55	30.3

DBSCAN-SWA_28

455154 : 457380

Mycobacterium_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000501018.1\|455154_455874_+	phage Gp37/Gp68 family protein	A0A088F7U1	Mycobacterium_phage	9.8e-48	42.0
WP_000950355.1\|456008_456815_-	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_000613919.1\|456924_457380_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	7.3e-25	54.5

DBSCAN-SWA_29

475491 : 476793

Clostridium_botulinum_C_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189239.1\|475491_476793_-	AAA family ATPase	Q331U3	Clostridium_botulinum_C_phage	1.1e-12	24.2

DBSCAN-SWA_30

486002 : 491089

Saudi_moumouvirus(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000805357.1\|486002_486761_+	NTP transferase domain-containing protein	A0A1S5V090	Saudi_moumouvirus	1.1e-28	32.0
WP_001012708.1\|486757_487696_+	ribose-phosphate pyrophosphokinase	A0A1V0SHF7	Hokovirus	4.8e-47	33.6
WP_000081487.1\|487713_488352_+	50S ribosomal protein L25/general stress protein Ctc	NA	NA	NA	NA
WP_000767698.1\|488398_488962_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
WP_001038998.1\|489121_491089_+	ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein	E5ESM9	Bathycoccus_sp._RCC1105_virus	5.5e-109	41.9

DBSCAN-SWA_31

494527 : 496024

Heterosigma_akashiwo_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001192497.1\|494527_496024_-	polyamine aminopropyltransferase	A0A1C9C533	Heterosigma_akashiwo_virus	1.9e-08	25.9

DBSCAN-SWA_32

502413 : 506925

Pike_perch_iridovirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002105879.1\|502413_504024_-	carboxyl transferase	A0A1B2ITV7	Pike_perch_iridovirus	1.6e-18	62.5
WP_001127234.1\|504040_505087_-	glucose-1-phosphate thymidylyltransferase	NA	NA	NA	NA
WP_000334327.1\|505092_506925_-	glutamine--fructose-6-phosphate transaminase (isomerizing)	A0A2P1EMF5	Moumouvirus	5.5e-103	39.0

DBSCAN-SWA_33

511734 : 512430

Cronobacter_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000868624.1\|511734_512430_+	glycosyltransferase family 2 protein	F1C5B0	Cronobacter_phage	2.7e-10	29.2

DBSCAN-SWA_34

546863 : 547247

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001011704.1\|546863_547247_-	fluoride efflux transporter CrcB	A0A2H4J148	uncultured_Caudovirales_phage	4.9e-14	41.3

DBSCAN-SWA_35

551059 : 557810

Pseudomonas_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000453255.1\|551059_552163_-	peptide chain release factor 2	W8EDB3	Pseudomonas_phage	7.0e-05	38.9
WP_001116208.1\|553044_553890_-	hypothetical protein	NA	NA	NA	NA
WP_002074675.1\|553891_555160_-	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_148636696.1\|555161_557810_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	9.8e-162	41.2

DBSCAN-SWA_36

574392 : 575088

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001021181.1\|574392_575088_-	hypothetical protein	S5VTJ1	Leptospira_phage	1.7e-12	27.1

DBSCAN-SWA_37

578718 : 583289

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000844277.1\|578718_581799_-	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	7.3e-294	52.7
WP_000584329.1\|581795_583289_-	efflux RND transporter periplasmic adaptor subunit	S5VL44	Leptospira_phage	3.5e-92	51.9

DBSCAN-SWA_38

610724 : 678190

Leptospira_phage(27.27%)

transposase,tRNA,integrase,holin

attL 608681:608701|attR 616500:616520

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
608681:608701	attL	NA	NA	NA	NA
WP_000846379.1\|610724_612020_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_002188477.1\|612217_612964_+	hypothetical protein	NA	NA	NA	NA
WP_000817677.1\|613098_614076_+	DUF1016 family protein	A0A218ML12	uncultured_virus	7.9e-08	39.4
WP_148636700.1\|614208_616317_+	hypothetical protein	NA	NA	NA	NA
WP_002188342.1\|616331_616940_+	lipoprotein, tandem type	NA	NA	NA	NA
616500:616520	attR	NA	NA	NA	NA
WP_139343786.1\|617446_617716_-\|transposase	transposase	NA	NA	NA	NA
WP_082285533.1\|617728_617944_-	hypothetical protein	NA	NA	NA	NA
WP_000568654.1\|618004_618298_-\|transposase	transposase	NA	NA	NA	NA
WP_000569939.1\|618370_618925_+	hypothetical protein	NA	NA	NA	NA
WP_000019011.1\|619477_620089_-	DUF3365 domain-containing protein	NA	NA	NA	NA
WP_000014140.1\|620275_621025_+	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_001257919.1\|622042_622558_+	crossover junction endodeoxyribonuclease RuvC	NA	NA	NA	NA
WP_000636526.1\|624020_624203_-	hypothetical protein	NA	NA	NA	NA
WP_002188329.1\|624208_626773_+	sulfatase-like hydrolase/transferase	NA	NA	NA	NA
WP_139343784.1\|627086_627311_-\|transposase	transposase family protein	S5WIN0	Leptospira_phage	4.3e-18	72.3
WP_002074720.1\|628660_629026_+\|transposase	transposase	NA	NA	NA	NA
WP_000214077.1\|629200_629383_-	hypothetical protein	NA	NA	NA	NA
WP_002188338.1\|630398_630839_-	host attachment protein	NA	NA	NA	NA
WP_000993135.1\|630961_631144_+	hypothetical protein	NA	NA	NA	NA
WP_000136057.1\|631543_632311_+	Fe-S cluster assembly ATPase SufC	A0A285PWH2	Cedratvirus	1.9e-09	30.1
WP_082280702.1\|632291_633515_+	Fe-S cluster assembly protein SufD	NA	NA	NA	NA
WP_000010050.1\|633511_633823_+	non-heme iron oxygenase ferredoxin subunit	NA	NA	NA	NA
WP_000010076.1\|633828_635070_+	cysteine desulfurase	Q2XUY6	environmental_halophage	2.2e-103	45.8
WP_000058819.1\|635053_635488_+	SUF system NifU family Fe-S cluster assembly protein	A0A2P1CJL8	Mycobacterium_phage	4.3e-14	37.8
WP_000395581.1\|635779_636139_+	metal-sulfur cluster assembly factor	NA	NA	NA	NA
WP_000908611.1\|636616_637408_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000860665.1\|637964_638492_-	DUF1697 domain-containing protein	NA	NA	NA	NA
WP_000282990.1\|639704_641621_-	DUF1561 domain-containing protein	NA	NA	NA	NA
WP_000656508.1\|642545_643508_-	hypothetical protein	NA	NA	NA	NA
WP_000967288.1\|643664_644942_+	EAL domain-containing protein	NA	NA	NA	NA
WP_001146925.1\|645902_646862_-	hypothetical protein	NA	NA	NA	NA
WP_002108878.1\|646879_648181_-	hypothetical protein	NA	NA	NA	NA
WP_000777856.1\|648183_648708_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_000812417.1\|648994_650269_-	hypothetical protein	NA	NA	NA	NA
WP_000217895.1\|653219_653663_-	hypothetical protein	NA	NA	NA	NA
WP_080010688.1\|654316_654499_+	hypothetical protein	NA	NA	NA	NA
WP_000891135.1\|654745_655789_-\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_001047901.1\|655950_656967_+	hypothetical protein	NA	NA	NA	NA
WP_002188340.1\|656966_658910_+\|tRNA	bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC	NA	NA	NA	NA
WP_000871570.1\|659107_659293_+	hypothetical protein	NA	NA	NA	NA
WP_000433097.1\|659861_660839_+	hypothetical protein	NA	NA	NA	NA
WP_000602007.1\|661022_661715_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000121149.1\|662193_662382_+	hypothetical protein	NA	NA	NA	NA
WP_000581113.1\|662388_662775_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_001075122.1\|663123_663573_+	hypothetical protein	NA	NA	NA	NA
WP_020380898.1\|665310_666975_+	sphingomyelin phosphodiesterase-like hemolysin SphH	A0A1P8L6H7	Staphylococcus_phage	8.9e-52	38.8
WP_001070149.1\|667316_668840_-	MFS transporter	A0A0M3UL24	Mycobacterium_phage	1.2e-34	29.7
WP_001226301.1\|668851_669400_-	dihydrofolate reductase	NA	NA	NA	NA
WP_000589277.1\|669401_670031_-	hypothetical protein	NA	NA	NA	NA
WP_082269148.1\|670555_670648_+\|transposase	transposase	NA	NA	NA	NA
WP_112120681.1\|670672_670855_+	hypothetical protein	NA	NA	NA	NA
WP_002078009.1\|670851_671703_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	1.4e-40	34.2
WP_082280485.1\|671751_671892_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_025177690.1\|672418_673234_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	2.0e-113	79.2
WP_002074414.1\|673227_673491_-\|transposase	transposase	S5WIS5	Leptospira_phage	8.5e-10	85.4
WP_002188383.1\|675293_676337_-	tetraacyldisaccharide 4'-kinase	NA	NA	NA	NA
WP_000172205.1\|676360_678190_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.8e-56	33.0

DBSCAN-SWA_39

687035 : 688670

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000626143.1\|687035_688670_+	ABC-F family ATPase	A0A2K9L0W2	Tupanvirus	1.6e-53	29.1

DBSCAN-SWA_40

692600 : 693257

Brazilian_cedratvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001181527.1\|692600_693257_-	CatB-related O-acetyltransferase	A0A2R8FE91	Brazilian_cedratvirus	8.1e-25	41.4

DBSCAN-SWA_41

702221 : 702878

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000200035.1\|702221_702878_-	uracil-DNA glycosylase	A0A127AW33	Bacillus_phage	4.3e-18	29.7

DBSCAN-SWA_42

707556 : 709647

Hokovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001005911.1\|707556_709647_-	response regulator	A0A1V0SGX0	Hokovirus	2.1e-50	34.0

DBSCAN-SWA_43

722394 : 722748

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000788957.1\|722394_722748_+	single-stranded DNA-binding protein	A0A1J0MFL8	Staphylococcus_phage	4.7e-11	39.2

DBSCAN-SWA_44

737880 : 738234

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000788957.1\|737880_738234_+	single-stranded DNA-binding protein	A0A1J0MFL8	Staphylococcus_phage	4.7e-11	39.2

DBSCAN-SWA_45

752366 : 761457

Bacillus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000954357.1\|752366_754187_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.3e-60	32.8
WP_000479265.1\|754258_754837_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	7.1e-49	49.7
WP_000449766.1\|754836_756258_-	anthranilate synthase component I	A0A0B5J984	Pandoravirus	3.5e-41	32.8
WP_000393538.1\|756344_757508_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_001172775.1\|757961_758159_-	hypothetical protein	NA	NA	NA	NA
WP_002188142.1\|758703_761457_-	DNA polymerase I	A0A0C5K9B9	Enterococcus_phage	1.1e-46	32.0

DBSCAN-SWA_46

765264 : 767610

Ostreococcus_tauri_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000797207.1\|765264_767610_+	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	6.8e-66	37.6

DBSCAN-SWA_47

789394 : 794050

Pithovirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000658301.1\|789394_789877_-	DNA starvation/stationary phase protection protein	W5S6G8	Pithovirus	2.8e-14	34.8
WP_000538757.1\|790361_791486_-	DegT/DnrJ/EryC1/StrS family aminotransferase	NA	NA	NA	NA
WP_002188150.1\|791530_794050_-	endopeptidase La	A0A0R6PGP8	Moraxella_phage	2.0e-132	37.3

DBSCAN-SWA_48

801304 : 804238

Tupanvirus(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000802921.1\|801304_804238_+\|tRNA	alanine--tRNA ligase	A0A2K9L3D8	Tupanvirus	9.1e-60	35.2

DBSCAN-SWA_49

811920 : 819578

Planktothrix_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001141158.1\|811920_812685_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.4e-12	31.1
WP_000754808.1\|812685_813375_-	hypothetical protein	NA	NA	NA	NA
WP_001015340.1\|813371_814508_-	hypothetical protein	NA	NA	NA	NA
WP_025177676.1\|815469_816192_+	ABC transporter ATP-binding protein	M1I2G3	Paramecium_bursaria_Chlorella_virus	1.3e-12	33.3
WP_000770652.1\|816163_816835_+	heme exporter protein B	NA	NA	NA	NA
WP_000702045.1\|816891_817584_+	cytochrome c biogenesis protein CcsA	NA	NA	NA	NA
WP_000075445.1\|817590_818724_+	response regulator	W8CYM9	Bacillus_phage	4.0e-11	30.6
WP_001070066.1\|818720_819578_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0M4JBD3	Mollivirus	1.3e-38	34.2

DBSCAN-SWA_50

823478 : 825167

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080011839.1\|823478_825167_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.5e-09	54.8

DBSCAN-SWA_51

838011 : 838164

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001976074.1\|838011_838164_-	hypothetical protein	S5WIU1	Leptospira_phage	1.3e-05	70.0

DBSCAN-SWA_52

844093 : 845234

Shigella_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_141566763.1\|844093_845234_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.0e-42	37.0

DBSCAN-SWA_53

875222 : 878344

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188445.1\|875222_877088_+	elongation factor G-like protein	A0A1S5SF82	Streptococcus_phage	4.6e-41	32.6
WP_001040571.1\|877138_878344_+	elongation factor Tu	A0A076FFS6	Aureococcus_anophage	1.8e-33	30.4

DBSCAN-SWA_54

888945 : 889509

Tenacibaculum_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000789400.1\|888945_889509_+	adenylate kinase	A0A1B4XWI3	Tenacibaculum_phage	7.4e-19	34.0

DBSCAN-SWA_55

902356 : 905452

Paramecium_bursaria_Chlorella_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002063873.1\|902356_903283_-	aspartate carbamoyltransferase	M1HWF9	Paramecium_bursaria_Chlorella_virus	3.9e-57	43.8
WP_001976063.1\|903320_904265_-	fatty acid desaturase	NA	NA	NA	NA
WP_000911426.1\|904762_905071_-	DUF2752 domain-containing protein	NA	NA	NA	NA
WP_001282554.1\|905131_905452_-	TM2 domain-containing protein	A0A240F358	Aeromonas_phage	2.0e-05	57.8

DBSCAN-SWA_56

914201 : 916451

Pseudomonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000712694.1\|914201_916451_-	lytic transglycosylase domain-containing protein	K4NWI2	Pseudomonas_phage	1.3e-08	31.5

DBSCAN-SWA_57

926934 : 930697

Halovirus(33.33%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000791380.1\|926934_927549_-	dTMP kinase	R4T6U6	Halovirus	7.9e-14	28.3
WP_001055380.1\|927658_928282_+\|protease	serine protease	NA	NA	NA	NA
WP_000798837.1\|928504_929671_+\|protease	trypsin-like serine protease	A0A1B1IT49	uncultured_Mediterranean_phage	1.9e-24	31.5
WP_001129835.1\|929671_930697_+	Holliday junction branch migration DNA helicase RuvB	A0A127AWE7	Bacillus_phage	9.1e-07	26.8

DBSCAN-SWA_58

961038 : 961935

Klosneuvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000403254.1\|961038_961935_+	hydroxymethylglutaryl-CoA lyase	A0A1V0SKU2	Klosneuvirus	3.3e-37	35.0

DBSCAN-SWA_59

966791 : 968911

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000801906.1\|966791_967664_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	5.5e-29	33.9
WP_002188436.1\|967660_968911_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	2.4e-86	45.0

DBSCAN-SWA_60

975473 : 980278

Micromonas_sp._RCC1109_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188457.1\|975473_977156_+	biosynthetic-type acetolactate synthase large subunit	E5EQ70	Micromonas_sp._RCC1109_virus	7.3e-62	29.9
WP_000780662.1\|977190_977505_+	hypothetical protein	NA	NA	NA	NA
WP_148636714.1\|978751_980278_-	HDOD domain-containing protein	A0A1C3NFB0	Phage_NCTB	1.0e-09	27.4

DBSCAN-SWA_61

1011149 : 1012781

Paramecium_bursaria_Chlorella_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000076961.1\|1011149_1012781_+	N-6 DNA methylase	A7IWU3	Paramecium_bursaria_Chlorella_virus	8.2e-10	31.9

DBSCAN-SWA_62

1050838 : 1051564

Flavobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000522360.1\|1050838_1051564_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	1.6e-18	38.1

DBSCAN-SWA_63

1059748 : 1062061

Pelagibacter_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001291053.1\|1059748_1062061_+	adenylate/guanylate cyclase domain-containing protein	M1HLN3	Pelagibacter_phage	2.8e-48	27.3

DBSCAN-SWA_64

1066057 : 1066546

Tetraselmis_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001093510.1\|1066057_1066546_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.1e-22	43.0

DBSCAN-SWA_65

1083586 : 1087194

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189049.1\|1083586_1084360_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	2.9e-29	33.7
WP_002187381.1\|1084613_1085057_-	PIN domain-containing protein	NA	NA	NA	NA
WP_000790422.1\|1085046_1085265_-	hypothetical protein	NA	NA	NA	NA
WP_002187444.1\|1085925_1087194_+	beta-propeller repeat protein	S5WIY5	Leptospira_phage	5.9e-48	43.5

DBSCAN-SWA_66

1130778 : 1135358

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148636722.1\|1130778_1132455_-	sphingomyelin phosphodiesterase	A0A1P8L6H7	Staphylococcus_phage	2.7e-56	44.0
WP_112120683.1\|1133486_1135358_-	sphingomyelin phosphodiesterase	A0A1P8L6H7	Staphylococcus_phage	9.3e-66	48.4

DBSCAN-SWA_67

1143418 : 1144537

Xanthomonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000576385.1\|1143418_1144537_-	M23 family metallopeptidase	A0A292GJG6	Xanthomonas_phage	3.4e-23	42.9

DBSCAN-SWA_68

1152806 : 1154186

Faecalibacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001276051.1\|1152806_1154186_+	DUF3383 family protein	A0A2K9V3L3	Faecalibacterium_phage	9.7e-12	26.4

DBSCAN-SWA_69

1159917 : 1161132

Aeribacillus_phage(100.0%)

plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000017270.1\|1159917_1161132_+\|plate	phage baseplate protein	A0A1L2JY69	Aeribacillus_phage	9.4e-43	33.2

DBSCAN-SWA_70

1176244 : 1181515

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187408.1\|1176244_1178323_+	potassium-transporting ATPase subunit KdpB	E4ZFI9	Streptococcus_phage	7.4e-40	28.3
WP_000576697.1\|1178333_1178906_+	potassium-transporting ATPase subunit KdpC	NA	NA	NA	NA
WP_000588676.1\|1178902_1181515_+	sensor histidine kinase KdpD	W8CYF6	Bacillus_phage	1.2e-18	29.5

DBSCAN-SWA_71

1195063 : 1196164

Lake_Baikal_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_082268447.1\|1195063_1196164_-	adenylate/guanylate cyclase domain-containing protein	A0A2H4N7Z5	Lake_Baikal_phage	1.6e-09	29.7

DBSCAN-SWA_72

1203837 : 1210998

Tupanvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000339880.1\|1203837_1206492_-	aminopeptidase N	A0A2K9L1R3	Tupanvirus	8.9e-46	33.3
WP_000195122.1\|1206631_1207888_-	MFS transporter	NA	NA	NA	NA
WP_000808789.1\|1207889_1208468_-	NUDIX hydrolase	NA	NA	NA	NA
WP_000777808.1\|1208973_1210998_+	UvrD-helicase domain-containing protein	A7KV33	Bacillus_phage	1.9e-101	33.4

DBSCAN-SWA_73

1234344 : 1235622

Megavirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001111751.1\|1234344_1235622_-	adenylosuccinate synthase	L7Y4J5	Megavirus	8.8e-68	33.1

DBSCAN-SWA_74

1243620 : 1244058

Kurlavirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000689546.1\|1243620_1244058_+	dUTP diphosphatase	A0A1S5XYX0	Kurlavirus	9.8e-27	45.0

DBSCAN-SWA_75

1253599 : 1258827

Acidianus_two-tailed_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000079210.1\|1253599_1254502_-	radical SAM protein	A0A1C9EG97	Acidianus_two-tailed_virus	2.0e-10	27.1
WP_002097444.1\|1254479_1255166_-	DNA alkylation repair enzyme	NA	NA	NA	NA
WP_000365021.1\|1255338_1257039_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_000493049.1\|1257209_1257875_-	protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	7.4e-18	46.2
WP_000876121.1\|1258053_1258296_-	hypothetical protein	NA	NA	NA	NA
WP_001001361.1\|1258395_1258827_+	ATP-binding protein	D4N407	Pseudomonas_phage	7.2e-14	33.1

DBSCAN-SWA_76

1265604 : 1266615

Acinetobacter_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000433680.1\|1265604_1266615_+	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	5.4e-52	35.1

DBSCAN-SWA_77

1269683 : 1275459

Staphylococcus_phage(75.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000459252.1\|1269683_1270622_+	protein translocase subunit SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	6.0e-21	35.8
WP_000202680.1\|1270621_1272022_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase	A0A2H4PQS8	Staphylococcus_phage	9.9e-12	29.9
WP_000494006.1\|1272006_1272609_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	2.7e-27	36.5
WP_000615785.1\|1274253_1275459_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.2e-108	51.0

DBSCAN-SWA_78

1283802 : 1284873

Bacillus_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000510774.1\|1283802_1284873_+	sulfate ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	4.7e-30	36.3

DBSCAN-SWA_79

1304131 : 1312786

Wolbachia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000516444.1\|1304131_1305913_+	DNA mismatch repair endonuclease MutL	A0A1B2LRQ5	Wolbachia_phage	1.7e-69	31.9
WP_000200976.1\|1305881_1306502_+	VTT domain-containing protein	NA	NA	NA	NA
WP_002082234.1\|1306624_1306984_-	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_000449692.1\|1307196_1307424_+	hypothetical protein	NA	NA	NA	NA
WP_001281336.1\|1307420_1308692_+	replication-associated recombination protein A	G3MBE0	Bacillus_virus	8.8e-68	39.3
WP_000263734.1\|1308692_1309010_-	hypothetical protein	NA	NA	NA	NA
WP_000538655.1\|1309767_1310880_-	histidinol-phosphate transaminase	NA	NA	NA	NA
WP_000923219.1\|1310878_1311004_+	hypothetical protein	NA	NA	NA	NA
WP_000655293.1\|1311021_1311192_+	hypothetical protein	NA	NA	NA	NA
WP_000604736.1\|1311193_1312786_-	2Fe-2S iron-sulfur cluster binding domain-containing protein	A0A218MLZ2	uncultured_virus	2.3e-25	36.4

DBSCAN-SWA_80

1318115 : 1320191

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000027575.1\|1318115_1320191_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.7e-15	31.0

DBSCAN-SWA_81

1326991 : 1330975

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000278813.1\|1326991_1327462_+	DUF192 domain-containing protein	A0A1B1IUW8	uncultured_Mediterranean_phage	2.1e-11	37.4
WP_001186895.1\|1327562_1328168_-	DUF3332 family protein	NA	NA	NA	NA
WP_000898728.1\|1328344_1329799_+	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	1.6e-52	35.2
WP_000016912.1\|1329931_1330291_+	PilZ domain-containing protein	NA	NA	NA	NA
WP_000378484.1\|1330354_1330975_+	sigma-70 family RNA polymerase sigma factor	A0A0F6TH34	Sinorhizobium_phage	4.7e-06	28.8

DBSCAN-SWA_82

1334137 : 1334857

Moraxella_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000422110.1\|1334137_1334857_-	TerC family protein	A0A0R6PEZ3	Moraxella_phage	1.0e-41	42.4

DBSCAN-SWA_83

1338199 : 1340002

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001071261.1\|1338199_1340002_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.5e-07	34.8

DBSCAN-SWA_84

1348464 : 1349868

Erysipelothrix_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001271671.1\|1348464_1349868_+	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	1.8e-45	28.5

DBSCAN-SWA_85

1356417 : 1358229

Catovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189117.1\|1356417_1358229_-	HSP90 family protein	A0A1V0SAD6	Catovirus	1.5e-28	26.3

DBSCAN-SWA_86

1362848 : 1367652

Halovirus(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000643186.1\|1362848_1363937_-	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	7.8e-57	36.1
WP_000284473.1\|1364189_1366106_+\|tRNA	threonine--tRNA ligase	A0A2K9L297	Tupanvirus	1.8e-136	40.1
WP_002109610.1\|1366772_1366952_+	hypothetical protein	NA	NA	NA	NA
WP_148636731.1\|1367112_1367652_+	translation initiation factor IF-3	A0A2L0UZ54	Agrobacterium_phage	1.0e-12	35.1

DBSCAN-SWA_87

1376380 : 1376944

uncultured_Mediterranean_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000439024.1\|1376380_1376944_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	6.1e-21	39.0

DBSCAN-SWA_88

1398806 : 1399520

Planktothrix_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001161018.1\|1398806_1399520_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-31	38.8

DBSCAN-SWA_89

1406685 : 1409718

Gordonia_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000450799.1\|1406685_1409718_+	AAA domain-containing protein	A0A0K0NLB1	Gordonia_phage	3.5e-06	30.5

DBSCAN-SWA_90

1414235 : 1414718

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000239366.1\|1414235_1414718_+	SsrA-binding protein	W5RAM5	Staphylococcus_phage	9.2e-26	43.0

DBSCAN-SWA_91

1435088 : 1440747

Microbacterium_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189039.1\|1435088_1437326_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.0e-144	41.2
WP_002188945.1\|1437341_1437995_+	hypothetical protein	NA	NA	NA	NA
WP_002106080.1\|1438002_1440747_+\|tRNA	isoleucine--tRNA ligase	A0A2K9L9X8	Tupanvirus	4.7e-90	28.4

DBSCAN-SWA_92

1450733 : 1452446

Ostreococcus_tauri_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188969.1\|1450733_1452446_+	AarF/ABC1/UbiB kinase family protein	A9YVW0	Ostreococcus_tauri_virus	3.9e-34	27.7

DBSCAN-SWA_93

1461356 : 1463193

Bacillus_thuringiensis_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000282526.1\|1461356_1461812_-	response regulator	Q56AR1	Bacillus_thuringiensis_phage	1.7e-05	28.3
WP_002188964.1\|1461804_1463193_-	hypothetical protein	W8CYF6	Bacillus_phage	7.0e-10	25.1

DBSCAN-SWA_94

1474976 : 1478808

Bodo_saltans_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000779365.1\|1474976_1475492_+	MepB family protein	A0A2H4UW84	Bodo_saltans_virus	2.0e-23	45.2
WP_000455147.1\|1475686_1476862_+	LCP family protein	NA	NA	NA	NA
WP_001070122.1\|1476868_1477240_+	ribosome silencing factor	NA	NA	NA	NA
WP_002189190.1\|1477275_1478808_+	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	2.1e-47	33.2

DBSCAN-SWA_95

1484116 : 1485346

Bodo_saltans_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000509587.1\|1484116_1485346_+	tetracycline resistance MFS efflux pump	A0A2H4UVM2	Bodo_saltans_virus	5.4e-06	19.9

DBSCAN-SWA_96

1498956 : 1500168

Salmonella_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000642916.1\|1498956_1500168_+	acyltransferase	A0A1R3Y5Q6	Salmonella_virus	5.0e-12	26.4

DBSCAN-SWA_97

1505386 : 1506781

Orpheovirus(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189166.1\|1505386_1506781_-\|tRNA	glycine--tRNA ligase	A0A2I2L3K8	Orpheovirus	2.2e-51	30.8

DBSCAN-SWA_98

1530143 : 1531391

Aeromonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001160150.1\|1530143_1531391_-	serine hydroxymethyltransferase	A0A219Y950	Aeromonas_phage	2.9e-92	51.4

DBSCAN-SWA_99

1541269 : 1546612

Bodo_saltans_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189119.1\|1541269_1546612_-	AAA family ATPase	A0A2H4UW49	Bodo_saltans_virus	1.3e-14	27.4

DBSCAN-SWA_100

1551069 : 1551828

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000653653.1\|1551069_1551828_+	glucose 1-dehydrogenase	W8CYX9	Bacillus_phage	6.1e-08	37.5

DBSCAN-SWA_101

1562598 : 1563264

Bodo_saltans_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000603361.1\|1562598_1563264_-	ABC transporter ATP-binding protein	A0A2H4UU96	Bodo_saltans_virus	6.5e-14	33.7

DBSCAN-SWA_102

1572891 : 1576231

Moraxella_phage(66.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000654116.1\|1572891_1573503_+	transcriptional repressor LexA	A0A2K9V3G4	Faecalibacterium_phage	1.9e-12	32.9
WP_000283525.1\|1573541_1573832_+	hypothetical protein	NA	NA	NA	NA
WP_148636739.1\|1573821_1575210_+	PDZ domain-containing protein	A0A0R6PIZ1	Moraxella_phage	4.1e-26	31.9
WP_000579852.1\|1575214_1576231_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	1.3e-53	37.7

DBSCAN-SWA_103

1582062 : 1584720

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000054169.1\|1582062_1583361_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	3.6e-16	30.1
WP_002189024.1\|1583409_1584720_+	UDP-glucose/GDP-mannose dehydrogenase family protein	A0A127AXI2	Bacillus_phage	2.8e-77	38.6

DBSCAN-SWA_104

1588387 : 1588876

Tetraselmis_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001093510.1\|1588387_1588876_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.1e-22	43.0

DBSCAN-SWA_105

1605916 : 1606690

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189049.1\|1605916_1606690_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	2.9e-29	33.7

DBSCAN-SWA_106

1671543 : 1672638

Pandoravirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148636742.1\|1671543_1672638_-	site-specific DNA-methyltransferase	S4VS49	Pandoravirus	3.0e-24	30.4

DBSCAN-SWA_107

1682634 : 1683411

Pseudomonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000602773.1\|1682634_1683411_+	nucleotidyltransferase domain-containing protein	A0A2D1GQQ2	Pseudomonas_phage	5.1e-42	42.0

DBSCAN-SWA_108

1691102 : 1693976

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189010.1\|1691102_1692104_-	beta-propeller repeat protein	S5WIY5	Leptospira_phage	9.5e-25	29.3
WP_000876503.1\|1692551_1693976_-	hypothetical protein	S5WIY5	Leptospira_phage	2.8e-22	29.3

DBSCAN-SWA_109

1698493 : 1711385

Acanthocystis_turfacea_Chlorella_virus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000410275.1\|1698493_1699450_+	GDP-L-fucose synthase	M1I5W5	Acanthocystis_turfacea_Chlorella_virus	1.2e-101	58.4
WP_000020777.1\|1699508_1700594_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_002076509.1\|1700598_1701270_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_001136118.1\|1701286_1702351_+	acetylneuraminic acid synthetase	A0A1B1IVE2	uncultured_Mediterranean_phage	7.5e-28	33.7
WP_000535866.1\|1702355_1703048_+	NTP transferase domain-containing protein	NA	NA	NA	NA
WP_000697359.1\|1703697_1705497_+	carbamoyltransferase	M4PR51	Cyanophage	4.8e-27	35.0
WP_001117632.1\|1705560_1706724_+	DegT/DnrJ/EryC1/StrS family aminotransferase	E5ES46	Bathycoccus_sp._RCC1105_virus	1.0e-14	26.4
WP_002189144.1\|1706726_1708478_+	carbamoyltransferase	E3SL71	Synechococcus_phage	5.8e-62	31.6
WP_000256648.1\|1708425_1710144_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_000041233.1\|1710131_1711385_+	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2P1ELT3	Moumouvirus	4.8e-34	32.8

DBSCAN-SWA_110

1721611 : 1727984

Indivirus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188948.1\|1721611_1722556_+	aldo/keto reductase	A0A1V0SDE7	Indivirus	2.4e-06	25.3
WP_002189187.1\|1722568_1723417_+	NeuB family protein	A0A1B1IVE2	uncultured_Mediterranean_phage	1.3e-30	35.5
WP_002098087.1\|1723419_1724385_+	hypothetical protein	NA	NA	NA	NA
WP_000580576.1\|1724381_1725065_+	WbqC family protein	NA	NA	NA	NA
WP_002078520.1\|1725069_1726275_+	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2K9L470	Tupanvirus	9.6e-32	29.6
WP_000614938.1\|1726277_1727984_+	ATP-binding cassette domain-containing protein	W8CYL7	Bacillus_phage	1.6e-27	24.0

DBSCAN-SWA_111

1731630 : 1733223

uncultured_Mediterranean_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025177745.1\|1731630_1732515_+	FkbM family methyltransferase	A0A1B1IVQ8	uncultured_Mediterranean_phage	2.6e-42	39.0
WP_001047905.1\|1732587_1733223_+	SIS domain-containing protein	A0A067XQR2	Caulobacter_phage	8.7e-16	36.3

DBSCAN-SWA_112

1740042 : 1742726

Klosneuvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189008.1\|1740042_1740693_+	galactoside O-acetyltransferase	A0A1V0SJ47	Klosneuvirus	4.3e-10	32.6
WP_002188971.1\|1740721_1741684_+	methyltransferase domain-containing protein	NA	NA	NA	NA
WP_002189029.1\|1741727_1742726_+	phosphoglycerate dehydrogenase	A0A285PXZ1	Cedratvirus	1.6e-27	30.1

DBSCAN-SWA_113

1750256 : 1755866

Klosneuvirus(60.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000723078.1\|1750256_1751255_+	SDR family NAD(P)-dependent oxidoreductase	A0A1V0SKV4	Klosneuvirus	2.5e-25	29.1
WP_000043898.1\|1751247_1751961_+	NTP transferase domain-containing protein	NA	NA	NA	NA
WP_000567887.1\|1751953_1752799_+	NAD(P)-dependent oxidoreductase	A0A1V0SKV4	Klosneuvirus	1.1e-10	28.2
WP_000952159.1\|1752846_1753743_+	SDR family oxidoreductase	A0A167RG57	Powai_lake_megavirus	3.8e-33	34.1
WP_000460023.1\|1753735_1754746_+	polysaccharide biosynthesis protein	K7Y9E1	Megavirus	1.7e-45	38.6
WP_000477468.1\|1754738_1755866_+	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A1V0SJE0	Klosneuvirus	2.8e-110	49.7

DBSCAN-SWA_114

1767520 : 1776526

Enterobacteria_phage(60.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000575178.1\|1767520_1768612_+	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2P1ELT3	Moumouvirus	3.1e-37	31.6
WP_000818302.1\|1768891_1769683_+	glycosyltransferase	NA	NA	NA	NA
WP_025177750.1\|1769751_1770597_+	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	6.2e-09	27.9
WP_002189145.1\|1771181_1772915_+	glycosyltransferase	NA	NA	NA	NA
WP_001159758.1\|1773110_1773671_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.5e-45	52.9
WP_000642153.1\|1773674_1774595_+	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_000723090.1\|1774591_1775641_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	4.5e-94	51.2
WP_000842260.1\|1775641_1776526_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	4.8e-97	60.3

DBSCAN-SWA_115

1788428 : 1793838

Lactobacillus_phage(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001262509.1\|1788428_1788881_+	single-stranded DNA-binding protein	L0P8Q2	Lactobacillus_phage	2.3e-15	41.7
WP_001293444.1\|1788892_1789204_+	30S ribosomal protein S18	NA	NA	NA	NA
WP_001263864.1\|1789213_1789663_+	50S ribosomal protein L9	NA	NA	NA	NA
WP_001190299.1\|1789680_1791009_+	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	1.4e-63	35.8
WP_000683521.1\|1791041_1792847_+\|tRNA	aspartate--tRNA ligase	A0A1V0SFI4	Hokovirus	1.4e-10	24.6
WP_000351423.1\|1792956_1793838_+	PhoH family protein	A0A223LII3	Erwinia_phage	4.3e-45	43.1

DBSCAN-SWA_116

1802678 : 1806797

Leptospira_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188957.1\|1802678_1804115_-	hypothetical protein	S5WIY5	Leptospira_phage	2.5e-34	28.5
WP_000282348.1\|1804671_1805664_-	response regulator	NA	NA	NA	NA
WP_000096813.1\|1805663_1806797_-	PAS domain-containing sensor histidine kinase	Q8QKW6	Ectocarpus_siliculosus_virus	9.4e-05	26.1

DBSCAN-SWA_117

1815621 : 1817070

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033108684.1\|1815621_1817070_-	PAS domain S-box protein	W8CYF6	Bacillus_phage	1.7e-14	27.9

DBSCAN-SWA_118

1820810 : 1827244

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000645000.1\|1820810_1821740_+	cysteine synthase A	A0A1X9I5F1	Streptococcus_phage	9.6e-80	52.2
WP_000054706.1\|1823284_1825126_+	type I DNA topoisomerase	A0A1S5V180	Saudi_moumouvirus	3.0e-77	34.7
WP_002188970.1\|1825471_1825666_-	hypothetical protein	NA	NA	NA	NA
WP_000651460.1\|1826431_1827244_-	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	2.6e-20	31.3

DBSCAN-SWA_119

1836666 : 1838115

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_033108684.1\|1836666_1838115_-	PAS domain S-box protein	W8CYF6	Bacillus_phage	1.7e-14	27.9

DBSCAN-SWA_120

1841855 : 1848289

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000645000.1\|1841855_1842785_+	cysteine synthase A	A0A1X9I5F1	Streptococcus_phage	9.6e-80	52.2
WP_000054706.1\|1844329_1846171_+	type I DNA topoisomerase	A0A1S5V180	Saudi_moumouvirus	3.0e-77	34.7
WP_002188970.1\|1846516_1846711_-	hypothetical protein	NA	NA	NA	NA
WP_000651460.1\|1847476_1848289_-	ATP-binding cassette domain-containing protein	W6JKT0	Anomala_cuprea_entomopoxvirus	2.6e-20	31.3

DBSCAN-SWA_121

1867954 : 1872701

Hokovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060589243.1\|1867954_1871572_+	response regulator	A0A1V0SGX0	Hokovirus	9.9e-40	30.4
WP_000837658.1\|1871585_1872701_+	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	1.9e-13	22.6

DBSCAN-SWA_122

1892448 : 1894305

Leptospira_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148636748.1\|1892448_1892985_-	helix-turn-helix domain-containing protein	S5WIW9	Leptospira_phage	3.3e-48	62.0
WP_001975957.1\|1892988_1894305_-\|transposase	IS5 family transposase	K4ICS3	Acidithiobacillus_phage	7.0e-44	41.8

DBSCAN-SWA_123

1903382 : 1915029

Tupanvirus(40.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000088216.1\|1903382_1904828_+	catalase	A0A2K9L0T1	Tupanvirus	7.4e-95	46.6
WP_000581323.1\|1905231_1907451_+	PAS domain-containing protein	A0A2K9L0Z8	Tupanvirus	3.6e-08	25.2
WP_000842773.1\|1907718_1908849_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_060589244.1\|1909640_1910408_-	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	NA	NA	NA	NA
WP_000570124.1\|1910392_1911808_-\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	7.3e-47	28.0
WP_001007972.1\|1911804_1912770_-	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_001070308.1\|1912785_1913640_-	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	1.0e-27	31.9
WP_000005293.1\|1913721_1915029_+\|tRNA	asparagine--tRNA ligase	M1PB22	Moumouvirus	2.2e-50	31.1

DBSCAN-SWA_124

1922235 : 1928912

Bacillus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187547.1\|1922235_1924212_-	DEAD/DEAH box helicase	A0A127AW80	Bacillus_phage	8.8e-83	30.3
WP_148636750.1\|1924330_1925923_-	symporter	NA	NA	NA	NA
WP_002130335.1\|1926329_1928912_+	ATP-dependent chaperone ClpB	A0A2I7SAX5	Vibrio_phage	1.9e-117	35.6

DBSCAN-SWA_125

1935624 : 1937427

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001280999.1\|1935624_1937427_+	elongation factor 4	E4ZFJ7	Streptococcus_phage	2.0e-20	23.1

DBSCAN-SWA_126

1946002 : 1947149

Acinetobacter_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_144421842.1\|1946002_1947149_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	3.1e-40	34.2

DBSCAN-SWA_127

1964632 : 1965856

Catovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001970514.1\|1964632_1965856_-	phosphoglycerate dehydrogenase	A0A1V0SBV6	Catovirus	4.4e-117	51.5

DBSCAN-SWA_128

1980205 : 1982838

uncultured_Mediterranean_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000165502.1\|1980205_1981006_-	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	5.1e-13	28.2
WP_000494959.1\|1981002_1981260_-	twin-arginine translocase TatA/TatE family subunit	NA	NA	NA	NA
WP_001197038.1\|1981663_1982473_+	hypothetical protein	NA	NA	NA	NA
WP_001970524.1\|1982523_1982838_+	thioredoxin	F2WLG3	Lausannevirus	1.6e-10	33.0

DBSCAN-SWA_129

1998785 : 1999195

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_082269552.1\|1998785_1998905_-	DNA-binding protein	S5VXX4	Leptospira_phage	4.1e-12	97.1
WP_002078075.1\|1998862_1999195_-	ankyrin repeat domain-containing protein	S5VXX4	Leptospira_phage	3.3e-06	89.7

DBSCAN-SWA_130

2005960 : 2008626

Streptococcus_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000018115.1\|2005960_2007259_+	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	1.9e-150	63.9
WP_000631734.1\|2007563_2008022_+	septum formation initiator family protein	NA	NA	NA	NA
WP_001115288.1\|2008032_2008626_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.6e-32	44.3

DBSCAN-SWA_131

2030705 : 2033133

unidentified_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000185977.1\|2030705_2032004_-	[cytidine(C)-cytidine(C)-adenosine (A)]-adding enzyme	H7BUW3	unidentified_phage	1.8e-39	47.2
WP_000606905.1\|2031996_2032398_-	hypothetical protein	NA	NA	NA	NA
WP_000628813.1\|2032743_2033133_-	ribonuclease HI family protein	A0A076FI68	Aureococcus_anophage	5.5e-13	39.8

DBSCAN-SWA_132

2050666 : 2052193

Klosneuvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000070955.1\|2050666_2052193_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	8.6e-78	35.3

DBSCAN-SWA_133

2057088 : 2058576

Catovirus(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188823.1\|2057088_2058576_-\|tRNA	lysine--tRNA ligase	A0A1V0SAC0	Catovirus	8.1e-89	37.8

DBSCAN-SWA_134

2114743 : 2115511

Anomala_cuprea_entomopoxvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000433117.1\|2114743_2115511_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.3e-18	27.8

DBSCAN-SWA_135

2120740 : 2122045

Pandoravirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001137844.1\|2120740_2122045_-	O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase	A0A0B5JD48	Pandoravirus	9.2e-12	23.0

DBSCAN-SWA_136

2126175 : 2127462

Acidianus_two-tailed_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000098174.1\|2126175_2127462_-	ATP-binding protein	A0A1C9EGA6	Acidianus_two-tailed_virus	5.3e-12	31.4

DBSCAN-SWA_137

2132937 : 2133813

Bodo_saltans_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001220028.1\|2132937_2133813_+	peptidylprolyl isomerase	A0A2H4UTF4	Bodo_saltans_virus	2.5e-13	29.6

DBSCAN-SWA_138

2139541 : 2141846

Dinoroseobacter_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000856053.1\|2139541_2139943_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	A0A1V0DYD3	Dinoroseobacter_phage	1.6e-15	42.2
WP_000234667.1\|2140034_2141846_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.8e-16	36.0

DBSCAN-SWA_139

2148289 : 2149649

Caulobacter_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000351733.1\|2148289_2148877_+	D-sedoheptulose 7-phosphate isomerase	A0A067XQR2	Caulobacter_phage	1.2e-14	32.5
WP_001089500.1\|2148887_2149649_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.0e-10	28.5

DBSCAN-SWA_140

2153319 : 2156222

Lactococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000459126.1\|2153319_2154321_+	cysteine synthase family protein	C3U2M1	Lactococcus_phage	1.4e-28	30.5
WP_000654985.1\|2154317_2156222_+	AAA family ATPase	A0A076FFX0	Aureococcus_anophage	2.1e-17	23.1

DBSCAN-SWA_141

2159634 : 2162207

uncultured_Mediterranean_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001279894.1\|2159634_2159970_+\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	1.4e-12	44.4
WP_002066457.1\|2159966_2162207_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	1.2e-149	37.9

DBSCAN-SWA_142

2169922 : 2172241

Anomala_cuprea_entomopoxvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000666552.1\|2169922_2170840_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.7e-25	31.7
WP_000666062.1\|2170858_2172241_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	9.0e-50	29.1

DBSCAN-SWA_143

2179713 : 2188823

Pseudomonas_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188095.1\|2179713_2181135_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	7.3e-47	33.3
WP_000682856.1\|2181170_2182157_-	signal peptide peptidase SppA	A0A1I9KF73	Aeromonas_phage	3.8e-10	26.7
WP_148636763.1\|2182298_2183204_+	aldose 1-epimerase	NA	NA	NA	NA
WP_000042798.1\|2184096_2185806_+	DEAD/DEAH box helicase	J9PUL8	Bacillus_phage	2.5e-09	28.1
WP_000365892.1\|2185857_2187072_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_000986261.1\|2187075_2188002_+	hypothetical protein	NA	NA	NA	NA
WP_001277162.1\|2187989_2188823_+	alpha/beta fold hydrolase	A0A2K9L3Q7	Tupanvirus	5.1e-08	27.8

DBSCAN-SWA_144

2195265 : 2198359

Emiliania_huxleyi_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188126.1\|2195265_2196396_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	V5LQ39	Emiliania_huxleyi_virus	1.9e-29	27.2
WP_000257883.1\|2196395_2197061_+	dethiobiotin synthase	NA	NA	NA	NA
WP_002188096.1\|2197057_2198359_+	adenosylmethionine--8-amino-7-oxononanoate transaminase	A0A1V0SKB7	Klosneuvirus	2.0e-14	22.8

DBSCAN-SWA_145

2201818 : 2205660

Acidithiobacillus_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001975957.1\|2201818_2203135_-\|transposase	IS5 family transposase	K4ICS3	Acidithiobacillus_phage	7.0e-44	41.8
WP_002188357.1\|2203236_2205660_-	DNA mismatch repair protein MutS	A0A1V0SDQ0	Indivirus	2.4e-37	26.4

DBSCAN-SWA_146

2209311 : 2212292

Klosneuvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000995952.1\|2209311_2210532_-	aspartate aminotransferase family protein	A0A1V0SKB7	Klosneuvirus	8.5e-28	27.6
WP_002188356.1\|2210528_2212292_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	4.2e-84	36.1

DBSCAN-SWA_147

2218002 : 2218425

Xanthomonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000451642.1\|2218002_2218425_+	acyl-CoA thioesterase	A0A292GK23	Xanthomonas_phage	4.0e-17	41.5

DBSCAN-SWA_148

2225728 : 2227510

Wolbachia_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000601251.1\|2225728_2227510_+	hypothetical protein	A0A1B2LRT6	Wolbachia_phage	1.1e-07	28.3

DBSCAN-SWA_149

2235008 : 2239319

Catovirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025177689.1\|2235008_2236946_-	long-chain fatty acid--CoA ligase	A0A1V0SBX8	Catovirus	4.4e-34	23.4
WP_000808031.1\|2236951_2237968_-	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
WP_000504720.1\|2238218_2239319_-	recombinase RecA	A0A0S2MVG1	Bacillus_phage	3.4e-116	61.1

DBSCAN-SWA_150

2257578 : 2259597

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000513099.1\|2257578_2259597_-	ATP-dependent helicase	A7KV33	Bacillus_phage	1.0e-73	30.3

DBSCAN-SWA_151

2267871 : 2275713

Micromonas_sp._RCC1109_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000116258.1\|2267871_2269458_-	2-isopropylmalate synthase	E5EQ69	Micromonas_sp._RCC1109_virus	9.8e-08	40.4
WP_000249791.1\|2269526_2269859_+	glyoxalase/bleomycin resistance/dioxygenase family protein	NA	NA	NA	NA
WP_002096975.1\|2269977_2270484_-	hypothetical protein	NA	NA	NA	NA
WP_000594559.1\|2271050_2271617_-	hypothetical protein	NA	NA	NA	NA
WP_000717401.1\|2271629_2272148_-	hypothetical protein	NA	NA	NA	NA
WP_002070937.1\|2272306_2273014_-	queuosine precursor transporter	A0A1W7AG82	Streptococcus_virus	1.9e-11	27.3
WP_000929872.1\|2273177_2274785_+	hydrolase	NA	NA	NA	NA
WP_001293686.1\|2274765_2275713_+	threonylcarbamoyl-AMP synthase	A0A291ATS8	Pandoravirus	6.4e-31	34.8

DBSCAN-SWA_152

2279309 : 2284837

uncultured_Mediterranean_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001156251.1\|2279309_2282156_+	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	1.1e-304	55.5
WP_000053472.1\|2282172_2283222_+	hypothetical protein	NA	NA	NA	NA
WP_000340844.1\|2283886_2284837_-	cation transporter	A0A1V0SED0	Indivirus	7.6e-08	32.7

DBSCAN-SWA_153

2289966 : 2305407

Paramecium_bursaria_Chlorella_virus(14.29%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_112120699.1\|2289966_2291493_+	HAD-IC family P-type ATPase	M1HX51	Paramecium_bursaria_Chlorella_virus	2.2e-25	29.4
WP_000610939.1\|2292125_2294624_+	response regulator	A0A1V0SGX0	Hokovirus	9.3e-29	29.3
WP_001045809.1\|2294662_2295811_+	hybrid sensor histidine kinase/response regulator	NA	NA	NA	NA
WP_000007881.1\|2296603_2297728_-	class 1 fructose-bisphosphatase	A0A1V0SKX4	Klosneuvirus	3.4e-63	43.1
WP_001971714.1\|2297795_2298239_+	hypothetical protein	NA	NA	NA	NA
WP_002068005.1\|2298202_2298397_+	hypothetical protein	NA	NA	NA	NA
WP_000372884.1\|2298350_2298563_+	hypothetical protein	NA	NA	NA	NA
WP_000232823.1\|2298738_2298948_+	30S ribosomal protein S21	NA	NA	NA	NA
WP_000058097.1\|2299007_2299454_+	GatB/YqeY domain-containing protein	A0A0K2FLI9	Brevibacillus_phage	4.8e-05	24.8
WP_000066267.1\|2299472_2301269_+	DNA primase	A0A1S5RG58	Helicobacter_phage	1.5e-41	30.4
WP_000429410.1\|2301285_2303043_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	2.4e-39	39.8
WP_001975957.1\|2304090_2305407_+\|transposase	IS5 family transposase	K4ICS3	Acidithiobacillus_phage	7.0e-44	41.8

DBSCAN-SWA_154

2314595 : 2316191

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001180837.1\|2314595_2316191_+	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.2e-08	34.3

DBSCAN-SWA_155

2321562 : 2323543

Moraxella_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188776.1\|2321562_2322012_-	peptidase M15	A0A0R6PGV9	Moraxella_phage	6.6e-10	33.3
WP_002188795.1\|2322016_2323543_-	hypothetical protein	A0A1W6DXS8	Aeromonas_phage	1.2e-07	44.7

DBSCAN-SWA_156

2328719 : 2329874

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188760.1\|2328719_2329874_-	replication initiation factor	A0A1S5SEX3	Streptococcus_phage	6.7e-06	27.6

DBSCAN-SWA_157

2334951 : 2335833

uncultured_Mediterranean_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188764.1\|2334951_2335833_+	FkbM family methyltransferase	A0A1B1IVQ8	uncultured_Mediterranean_phage	2.6e-34	36.8

DBSCAN-SWA_158

2339581 : 2343823

Bacillus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188774.1\|2339581_2340322_+	NAD-dependent deacylase	S5M4R0	Bacillus_phage	2.0e-24	28.6
WP_000489550.1\|2341258_2342329_-	DUF1574 domain-containing protein	NA	NA	NA	NA
WP_000898533.1\|2342338_2343823_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	1.6e-49	32.5

DBSCAN-SWA_159

2364690 : 2373142

Prochlorococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000212323.1\|2364690_2365317_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.2e-22	37.1
WP_000614724.1\|2365320_2366856_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	E3SNU8	Prochlorococcus_phage	3.2e-48	55.4
WP_000394959.1\|2366858_2367485_+	hypothetical protein	NA	NA	NA	NA
WP_001217817.1\|2367515_2368247_+	hypothetical protein	NA	NA	NA	NA
WP_000424879.1\|2368426_2369071_+	fructose-6-phosphate aldolase	R9S7J6	Prochlorococcus_phage	1.8e-48	49.8
WP_002188783.1\|2369233_2369542_+	hypothetical protein	NA	NA	NA	NA
WP_000725565.1\|2370663_2371710_-	DUF1574 domain-containing protein	NA	NA	NA	NA
WP_001009422.1\|2371723_2373142_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	4.6e-41	32.7

DBSCAN-SWA_160

2386525 : 2393235

Bacillus_thuringiensis_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188249.1\|2386525_2387194_+	SDR family oxidoreductase	Q56AQ6	Bacillus_thuringiensis_phage	1.1e-08	31.4
WP_000447212.1\|2387529_2388543_+	UDP-3-O-acyl-N-acetylglucosamine deacetylase	NA	NA	NA	NA
WP_000621270.1\|2388588_2390418_+	phosphoenolpyruvate--protein phosphotransferase	A0A1V0SGR7	Hokovirus	3.0e-08	29.2
WP_000148177.1\|2390414_2391095_-	hypothetical protein	NA	NA	NA	NA
WP_000829697.1\|2391189_2393235_-	AMP-binding protein	A0A1V0SBX8	Catovirus	2.3e-17	24.6

DBSCAN-SWA_161

2398171 : 2400370

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000378422.1\|2398171_2400370_-	UvrD-helicase domain-containing protein	A7KV33	Bacillus_phage	3.4e-99	36.2

DBSCAN-SWA_162

2408927 : 2409899

Synechococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001074785.1\|2408927_2409899_-	ADP-glyceromanno-heptose 6-epimerase	A0A1D8KKD9	Synechococcus_phage	2.4e-25	30.0

DBSCAN-SWA_163

2427030 : 2429944

Erwinia_phage(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001273642.1\|2427030_2428470_-\|protease	ATP-dependent protease ATPase subunit HslU	A0A191ZC11	Erwinia_phage	2.6e-44	28.7
WP_001114726.1\|2428479_2429022_-\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_002079116.1\|2429008_2429944_-	tyrosine recombinase XerC	A0A0K2CP59	Brevibacillus_phage	3.2e-27	30.6

DBSCAN-SWA_164

2436791 : 2442925

Hokovirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000390226.1\|2436791_2438060_+	exodeoxyribonuclease VII large subunit	A0A1V0SGL7	Hokovirus	3.5e-32	32.3
WP_000230450.1\|2438061_2438349_+	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_002188210.1\|2439319_2442925_+	vitamin B12-dependent ribonucleotide reductase	A0A1X9SGV9	Bradyrhizobium_phage	0.0e+00	54.1

DBSCAN-SWA_165

2454489 : 2458253

Vibrio_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000017091.1\|2454489_2456280_-	type II secretion system secretin GspD	R9TEZ5	Vibrio_phage	3.7e-19	27.3
WP_000991320.1\|2456284_2457193_-	general secretion pathway protein GspC	NA	NA	NA	NA
WP_002080535.1\|2457248_2458253_-	M23 family metallopeptidase	A0A1B0XUH3	Freshwater_phage	2.8e-16	43.6

DBSCAN-SWA_166

2463929 : 2464625

Cafeteria_roenbergensis_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001114919.1\|2463929_2464625_-	ribonuclease HII	E3T5H8	Cafeteria_roenbergensis_virus	3.2e-19	37.4

DBSCAN-SWA_167

2469121 : 2470069

Prochlorococcus_phage(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000690652.1\|2469121_2470069_-\|tRNA	methionyl-tRNA formyltransferase	E3SNR5	Prochlorococcus_phage	4.8e-10	33.1

DBSCAN-SWA_168

2478760 : 2489225

Staphylococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000369327.1\|2478760_2479468_-	LPS export ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.3e-20	28.4
WP_000621222.1\|2479498_2480869_-	hypothetical protein	NA	NA	NA	NA
WP_000791967.1\|2480865_2481450_-	LPS export ABC transporter periplasmic protein LptC	NA	NA	NA	NA
WP_002188221.1\|2481461_2482325_-	3-deoxy-8-phosphooctulonate synthase	E3T537	Cafeteria_roenbergensis_virus	8.1e-49	39.7
WP_000091728.1\|2482327_2483944_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	9.9e-149	50.9
WP_000364507.1\|2484142_2484619_-	D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase	A0A0K0KVL9	Prochlorococcus_phage	2.8e-19	38.9
WP_000291586.1\|2484619_2485633_-	D-glycero-beta-D-manno-heptose-7-phosphate kinase	A0A2H4N7X4	Lake_Baikal_phage	4.5e-14	26.4
WP_000938166.1\|2485687_2486308_+	LON peptidase substrate-binding domain-containing protein	NA	NA	NA	NA
WP_002188220.1\|2486599_2487871_-	C40 family peptidase	NA	NA	NA	NA
WP_000383078.1\|2487920_2489225_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.2e-61	31.0

DBSCAN-SWA_169

2495144 : 2504432

Bacillus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000433635.1\|2495144_2497340_+	PAS domain S-box protein	W8CYF6	Bacillus_phage	2.1e-29	35.5
WP_000402080.1\|2497302_2498565_+	response regulator	NA	NA	NA	NA
WP_000821665.1\|2498578_2498941_+	response regulator	W8CYM9	Bacillus_phage	4.2e-15	39.3
WP_000010492.1\|2498949_2499312_+	STAS domain-containing protein	NA	NA	NA	NA
WP_002188206.1\|2499315_2501457_+	chemotaxis protein CheA	NA	NA	NA	NA
WP_000488887.1\|2501501_2504432_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	7.3e-09	67.9

DBSCAN-SWA_170

2516247 : 2520046

Vibrio_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000116243.1\|2516247_2516784_+	peptide deformylase	A0A2I7S809	Vibrio_phage	2.1e-15	31.8
WP_000839353.1\|2516803_2520046_+	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	6.3e-78	26.1

DBSCAN-SWA_171

2526484 : 2535002

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187457.1\|2526484_2528701_-	leucine rich repeat protein	S5W9G5	Leptospira_phage	5.6e-09	66.1
WP_000915022.1\|2529598_2530570_-	membrane protein	NA	NA	NA	NA
WP_002187459.1\|2530702_2530888_-	hypothetical protein	NA	NA	NA	NA
WP_033110667.1\|2530878_2531061_+	hypothetical protein	NA	NA	NA	NA
WP_002187461.1\|2531057_2532638_-	hypothetical protein	S5W9G5	Leptospira_phage	5.3e-14	66.2
WP_002187452.1\|2532708_2533995_-	hypothetical protein	S5W9G5	Leptospira_phage	2.5e-09	67.9
WP_082280705.1\|2534204_2535002_-	hypothetical protein	S5W9G5	Leptospira_phage	1.4e-10	61.8

DBSCAN-SWA_172

2544844 : 2545783

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187475.1\|2544844_2545783_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.8e-26	34.1

DBSCAN-SWA_173

2561514 : 2562411

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000204200.1\|2561514_2562411_-	site-specific tyrosine recombinase XerD	S5W9T9	Leptospira_phage	6.3e-20	28.6

DBSCAN-SWA_174

2565719 : 2567156

Pseudomonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000898586.1\|2565719_2567156_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	7.6e-60	36.3

DBSCAN-SWA_175

2570167 : 2571118

Orpheovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000940581.1\|2570167_2571118_+	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	6.3e-79	50.0

DBSCAN-SWA_176

2575286 : 2576807

Bathycoccus_sp._RCC1105_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000810425.1\|2575286_2576807_+	hypothetical protein	E5ERA2	Bathycoccus_sp._RCC1105_virus	1.7e-17	26.8

DBSCAN-SWA_177

2598140 : 2598905

Phaeocystis_globosa_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002095680.1\|2598140_2598905_+	exodeoxyribonuclease III	R4TWA8	Phaeocystis_globosa_virus	7.2e-25	32.6

DBSCAN-SWA_178

2605585 : 2606578

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000377275.1\|2605585_2606578_-	diguanylate cyclase	A0A127AWB9	Bacillus_phage	1.2e-16	34.8

DBSCAN-SWA_179

2613586 : 2617128

Catovirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001141641.1\|2613586_2614045_-	peptidylprolyl isomerase	A0A1V0S9I2	Catovirus	3.7e-24	44.0
WP_000889674.1\|2614245_2617128_+	HAMP domain-containing protein	A0A2H4N7Z5	Lake_Baikal_phage	3.2e-33	37.3

DBSCAN-SWA_180

2620987 : 2627661

Tupanvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187456.1\|2620987_2622859_-	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	3.0e-48	29.7
WP_000433374.1\|2622901_2624308_-	PAS domain S-box protein	NA	NA	NA	NA
WP_000202857.1\|2624607_2627661_+	response regulator	A0A1V0SGX0	Hokovirus	1.6e-51	31.0

DBSCAN-SWA_181

2634146 : 2635268

Feldmannia_irregularis_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001146730.1\|2634146_2635268_-	HAMP domain-containing histidine kinase	Q6XLV6	Feldmannia_irregularis_virus	1.5e-07	23.8

DBSCAN-SWA_182

2641451 : 2643321

Bacillus_virus(50.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001085748.1\|2641451_2642714_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	4.4e-136	60.1
WP_000111455.1\|2642724_2643321_-	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	2.0e-54	57.1

DBSCAN-SWA_183

2651267 : 2661763

Ostreococcus_lucimarinus_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000701966.1\|2651267_2653046_-	biosynthetic-type acetolactate synthase large subunit	G9E4W7	Ostreococcus_lucimarinus_virus	1.3e-21	27.1
WP_000431183.1\|2653406_2654516_+	tetratricopeptide repeat protein	NA	NA	NA	NA
WP_000999373.1\|2655064_2657605_+	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	8.9e-11	31.2
WP_000454661.1\|2657685_2657955_+	hypothetical protein	NA	NA	NA	NA
WP_000063951.1\|2658295_2660299_-	helicase	NA	NA	NA	NA
WP_002187504.1\|2660470_2661763_+	AarF/ABC1/UbiB kinase family protein	A0A0R6PKQ6	Moraxella_phage	3.0e-71	37.2

DBSCAN-SWA_184

2684536 : 2685118

Mollivirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_080010664.1\|2684536_2685118_-	guanylate kinase	A0A0M5KCK5	Mollivirus	2.3e-07	26.9

DBSCAN-SWA_185

2688866 : 2689667

Paenibacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000039671.1\|2688866_2689667_-	RNA polymerase sigma factor WhiG	A0A2I7SC33	Paenibacillus_phage	6.4e-08	28.6

DBSCAN-SWA_186

2701635 : 2706334

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000938821.1\|2701635_2703861_-	phosphatidylserine decarboxylase	A0A2K9L6Z6	Tupanvirus	8.0e-16	29.2
WP_001202903.1\|2703923_2704790_+	hypothetical protein	NA	NA	NA	NA
WP_001162077.1\|2705137_2706334_-	sterol desaturase family protein	A0A2K9L1K6	Tupanvirus	2.8e-07	26.4

DBSCAN-SWA_187

2718395 : 2720125

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000053346.1\|2718395_2719556_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	2.5e-117	55.8
WP_000702765.1\|2719726_2720125_+	ParB N-terminal domain-containing protein	Q331U1	Clostridium_botulinum_C_phage	2.6e-10	33.0

DBSCAN-SWA_188

2725756 : 2737570

uncultured_virus(60.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148636781.1\|2725756_2727919_+	TonB-dependent siderophore receptor	A0A0P0I887	Acinetobacter_phage	3.6e-05	25.7
WP_000680175.1\|2728474_2729311_-	oxidoreductase	NA	NA	NA	NA
WP_001067952.1\|2729275_2730613_+	adenylate/guanylate cyclase domain-containing protein	A0A218MLZ2	uncultured_virus	2.1e-27	30.3
WP_001260470.1\|2730803_2731286_-	hypothetical protein	NA	NA	NA	NA
WP_001198057.1\|2731520_2731703_-	hypothetical protein	NA	NA	NA	NA
WP_000206200.1\|2732090_2732435_-	DUF962 domain-containing protein	NA	NA	NA	NA
WP_000486582.1\|2732724_2734275_-	deoxyribodipyrimidine photo-lyase	A0A068EKY2	Pigeonpox_virus	4.2e-48	30.4
WP_148636783.1\|2735624_2735915_+	co-chaperone GroES	A0A221S3C8	uncultured_virus	6.5e-19	49.5
WP_001029963.1\|2735929_2737570_+	chaperonin GroEL	A0A219YK78	uncultured_virus	2.5e-160	57.5

DBSCAN-SWA_189

2777742 : 2778846

Mamastrovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000146501.1\|2777742_2778846_-	dehypoxanthine futalosine cyclase	A9ZMK9	Mamastrovirus	3.7e-22	42.7

DBSCAN-SWA_190

2799414 : 2801127

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187789.1\|2799414_2801127_-	peptide chain release factor 3	A0A2K9L6L3	Tupanvirus	7.1e-12	35.8

DBSCAN-SWA_191

2837983 : 2839408

Pseudomonas_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000898557.1\|2837983_2839408_-	MBOAT family protein	A0A125RNP0	Pseudomonas_phage	1.9e-50	35.3

DBSCAN-SWA_192

2883279 : 2885004

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011172165.1\|2883279_2885004_-	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.3e-08	33.1

DBSCAN-SWA_193

2902753 : 2912521

Hokovirus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000462389.1\|2902753_2903881_-	PAS domain-containing sensor histidine kinase	A0A1V0SGX0	Hokovirus	1.2e-20	30.3
WP_011069722.1\|2904011_2905427_-	PAS domain S-box protein	NA	NA	NA	NA
WP_000826015.1\|2905494_2907786_-	cyclic nucleotide-binding domain-containing protein	A0A1V0SKV5	Klosneuvirus	3.5e-06	28.7
WP_001974549.1\|2908639_2909911_-	GAF domain-containing protein	A0A218MLZ2	uncultured_virus	2.5e-30	36.4
WP_001974506.1\|2909913_2910318_-	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_000060053.1\|2910314_2910782_-	hypothetical protein	NA	NA	NA	NA
WP_000004530.1\|2911585_2912521_+	ornithine carbamoyltransferase	M1HWF9	Paramecium_bursaria_Chlorella_virus	1.6e-13	26.7

DBSCAN-SWA_194

2938673 : 2940092

Erysipelothrix_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001115270.1\|2938673_2940092_+	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	5.6e-39	27.6

DBSCAN-SWA_195

2950283 : 2951072

Clostridium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000824202.1\|2950283_2951072_-	M23 family metallopeptidase	Q8SBN9	Clostridium_phage	4.0e-18	46.7

DBSCAN-SWA_196

2974770 : 2984242

Bacillus_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000872978.1\|2974770_2975712_+	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	6.0e-21	38.4
WP_000455908.1\|2975832_2976780_+	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	3.4e-16	36.2
WP_001008596.1\|2976799_2977753_+	sensor domain-containing diguanylate cyclase	NA	NA	NA	NA
WP_000180846.1\|2977776_2978703_+	sensor domain-containing diguanylate cyclase	NA	NA	NA	NA
WP_001199111.1\|2978789_2979731_+	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	2.7e-21	35.4
WP_000121860.1\|2979818_2980739_+	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	3.9e-17	35.8
WP_000362658.1\|2980845_2981808_+	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	6.3e-18	35.5
WP_001080002.1\|2981868_2983119_-	chloride channel protein	NA	NA	NA	NA
WP_001970060.1\|2983129_2984242_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.8e-70	45.8

DBSCAN-SWA_197

2998298 : 2999174

Feldmannia_irregularis_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_061252218.1\|2998298_2999174_+	response regulator	Q6XM27	Feldmannia_irregularis_virus	8.6e-06	25.8

DBSCAN-SWA_198

3018912 : 3023454

Leptospira_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187973.1\|3018912_3019515_+	leucine-rich repeat domain-containing protein	S5WIX4	Leptospira_phage	1.7e-05	46.3
WP_000804037.1\|3019532_3020123_+	leucine-rich repeat domain-containing protein	NA	NA	NA	NA
WP_000851065.1\|3020119_3020434_+	hypothetical protein	NA	NA	NA	NA
WP_000247973.1\|3020430_3021756_-	adenylate/guanylate cyclase domain-containing protein	A0A218MLZ2	uncultured_virus	1.0e-26	30.7
WP_002187910.1\|3021879_3022065_-	hypothetical protein	NA	NA	NA	NA
WP_001099029.1\|3022560_3023454_-	glycosyltransferase	A0A1V0SAH6	Catovirus	4.2e-08	32.7

DBSCAN-SWA_199

3035007 : 3037548

Pseudomonas_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000162390.1\|3035007_3036132_+	SpoIID/LytB domain-containing protein	Q2XU88	Pseudomonas_phage	7.4e-26	34.6
WP_000184524.1\|3036852_3037548_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.7e-36	40.2

DBSCAN-SWA_200

3043273 : 3052558

Hokovirus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000913344.1\|3043273_3043858_-	orotate phosphoribosyltransferase	A0A1V0SHG3	Hokovirus	1.5e-09	30.2
WP_001192262.1\|3043953_3045882_+	NAD(+) synthase	A0A2L0UZF5	Agrobacterium_phage	1.8e-16	30.1
WP_000623627.1\|3046936_3047638_-	hypothetical protein	NA	NA	NA	NA
WP_000273875.1\|3047752_3048493_+	hypothetical protein	NA	NA	NA	NA
WP_001083567.1\|3048489_3049242_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	3.0e-31	34.9
WP_000150993.1\|3049254_3049578_+	hypothetical protein	NA	NA	NA	NA
WP_001122024.1\|3049654_3050821_+	iron-containing alcohol dehydrogenase	NA	NA	NA	NA
WP_000618030.1\|3050817_3051237_-	hypothetical protein	NA	NA	NA	NA
WP_148636799.1\|3051835_3052558_+	glycoside hydrolase family 25 protein	D0R7H8	Paenibacillus_phage	6.4e-23	34.9

DBSCAN-SWA_201

3056743 : 3059277

Bacillus_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000670773.1\|3056743_3058207_-	polynucleotide adenylyltransferase PcnB	G3MAR3	Bacillus_virus	1.1e-24	32.9
WP_000625244.1\|3058260_3059277_+	M23 family metallopeptidase	A8ATH6	Listeria_phage	1.9e-17	45.0

DBSCAN-SWA_202

3063869 : 3066716

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000444199.1\|3063869_3066716_-	DNA translocase FtsK	A0A218M9A2	Mycobacterium_phage	3.5e-80	45.9

DBSCAN-SWA_203

3080971 : 3082321

Penguinpox_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000379034.1\|3080971_3082321_-	ankyrin repeat domain-containing protein	A0A068EEM9	Penguinpox_virus	3.5e-06	28.8

DBSCAN-SWA_204

3097089 : 3098187

Pithovirus(100.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001976240.1\|3097089_3098187_-\|protease	trypsin-like serine protease	W5SAB9	Pithovirus	7.2e-10	31.9

DBSCAN-SWA_205

3115814 : 3116810

Salmonella_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000840860.1\|3115814_3116810_+	glycosyltransferase family 2 protein	A8CG95	Salmonella_phage	2.8e-53	36.5

DBSCAN-SWA_206

3131314 : 3132616

Gordonia_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000567237.1\|3131314_3132616_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.7e-18	31.5

DBSCAN-SWA_207

3136206 : 3138231

uncultured_Mediterranean_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148636803.1\|3136206_3138231_-	RelA/SpoT family protein	A0A1B1IUF0	uncultured_Mediterranean_phage	4.1e-11	36.5

DBSCAN-SWA_208

3160527 : 3163773

Clostridium_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000843317.1\|3160527_3162195_-	lipoprotein LipL71	A0A0A7RVP5	Clostridium_phage	9.6e-06	54.2
WP_000406878.1\|3162242_3162578_-	STAS domain-containing protein	NA	NA	NA	NA
WP_000577236.1\|3162648_3163773_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.7e-79	43.1

DBSCAN-SWA_209

3172149 : 3173118

uncultured_Mediterranean_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000562954.1\|3172149_3173118_-	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A1B1IUU3	uncultured_Mediterranean_phage	9.2e-09	35.5

DBSCAN-SWA_210

3182073 : 3183255

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000345339.1\|3182073_3183255_+	AraC family transcriptional regulator	S5WIW9	Leptospira_phage	2.2e-36	31.7

DBSCAN-SWA_211

3206059 : 3207073

Acanthamoeba_polyphaga_mimivirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188514.1\|3206059_3207073_-	NAD(P)-dependent alcohol dehydrogenase	A0A0G2YAX3	Acanthamoeba_polyphaga_mimivirus	4.5e-14	26.9

DBSCAN-SWA_212

3210793 : 3211940

Acinetobacter_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_141228048.1\|3210793_3211940_+\|transposase	IS3-like element IS1500B family transposase	A0A0P0I4A4	Acinetobacter_phage	6.3e-41	34.5

DBSCAN-SWA_213

3217953 : 3222273

Indivirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001060166.1\|3217953_3218790_+	aldo/keto reductase	A0A1V0SDE7	Indivirus	9.9e-44	37.4
WP_000590871.1\|3220776_3222273_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	1.8e-59	32.4

DBSCAN-SWA_214

3246222 : 3249675

Fusobacterium_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001140542.1\|3246222_3246651_+	RNA-binding protein	A0A0E3U240	Fusobacterium_phage	1.5e-16	35.8
WP_002188754.1\|3246643_3246826_-	hypothetical protein	NA	NA	NA	NA
WP_002188742.1\|3247000_3248542_+	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	1.7e-102	41.8
WP_029759196.1\|3248553_3249675_+	restriction endonuclease subunit S	E3T4D5	Cafeteria_roenbergensis_virus	1.2e-12	32.2

DBSCAN-SWA_215

3263246 : 3266744

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000558142.1\|3263246_3266744_-	PAS domain-containing protein	A0A2K9L5I4	Tupanvirus	5.5e-11	32.2

DBSCAN-SWA_216

3284910 : 3286710

Lake_Baikal_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002069043.1\|3284910_3286710_-	adenylate/guanylate cyclase domain-containing protein	A0A2H4N7Z5	Lake_Baikal_phage	1.7e-32	36.8

DBSCAN-SWA_217

3312927 : 3315177

Lake_Baikal_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148636818.1\|3312927_3315177_-	HAMP domain-containing protein	A0A2H4N7Z5	Lake_Baikal_phage	1.7e-34	34.6

DBSCAN-SWA_218

3339661 : 3345943

Brazilian_cedratvirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001982953.1\|3339661_3340597_-	ABC transporter ATP-binding protein	A0A2R8FG22	Brazilian_cedratvirus	1.2e-16	31.0
WP_002095750.1\|3340967_3342806_-	exodeoxyribonuclease V subunit alpha	A0A167R0P7	Powai_lake_megavirus	1.1e-13	23.9
WP_148636820.1\|3342802_3345943_-	UvrD-helicase domain-containing protein	S5MMD7	Bacillus_phage	7.1e-26	22.5

DBSCAN-SWA_219

3349435 : 3350884

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000202873.1\|3349435_3350884_+	ATP-dependent DNA helicase RecQ	A0A2K9L021	Tupanvirus	1.1e-69	41.6

DBSCAN-SWA_220

3371531 : 3384268

Clostridioides_phage(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002109126.1\|3371531_3374471_-	N-6 DNA methylase	A0A2R2ZGH5	Clostridioides_phage	2.3e-47	25.1
WP_001157779.1\|3376702_3377986_-	insulinase family protein	G3MBJ8	Bacillus_virus	5.4e-33	25.1
WP_000149883.1\|3378007_3380104_-	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
WP_000562102.1\|3380115_3380382_-	30S ribosomal protein S15	NA	NA	NA	NA
WP_001082023.1\|3380433_3381363_-\|tRNA	tRNA pseudouridine(55) synthase TruB	A0A1V0SF38	Hokovirus	1.6e-05	22.8
WP_001068307.1\|3381319_3381673_-	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_000389642.1\|3381682_3384268_-	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	4.2e-24	24.6

DBSCAN-SWA_221

3411621 : 3412563

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188630.1\|3411621_3412563_+	histone deacetylase	A0A2K9L0I3	Tupanvirus	3.6e-42	33.8

DBSCAN-SWA_222

3431670 : 3437180

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001977383.1\|3431670_3432702_-	alcohol dehydrogenase catalytic domain-containing protein	E3SJ82	Synechococcus_phage	8.5e-29	27.6
WP_000379289.1\|3432989_3433565_+	PaaI family thioesterase	NA	NA	NA	NA
WP_000571791.1\|3434363_3435038_+	glutathione S-transferase family protein	NA	NA	NA	NA
WP_000186015.1\|3435041_3437180_-	sensor histidine kinase	A0A2K9L5I4	Tupanvirus	7.5e-11	32.6

DBSCAN-SWA_223

3468159 : 3478974

Vibrio_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_148636824.1\|3468159_3472374_-	DNA-directed RNA polymerase subunit beta'	A0A2I7QNZ7	Vibrio_phage	2.9e-67	26.1
WP_000274330.1\|3472377_3476058_-	DNA-directed RNA polymerase subunit beta	A0A2P0VMZ3	Tetraselmis_virus	3.4e-35	28.9
WP_000102400.1\|3476280_3476664_-	50S ribosomal protein L7/L12	NA	NA	NA	NA
WP_148636826.1\|3476713_3477247_-	50S ribosomal protein L10	NA	NA	NA	NA
WP_001188789.1\|3477274_3477967_-	50S ribosomal protein L1	NA	NA	NA	NA
WP_000729204.1\|3477973_3478402_-	50S ribosomal protein L11	NA	NA	NA	NA
WP_000536871.1\|3478428_3478974_-	transcription termination/antitermination factor NusG	G3MAW2	Bacillus_virus	1.8e-06	27.7

DBSCAN-SWA_224

3484745 : 3485837

Vibrio_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_060684621.1\|3484745_3485837_-	N-acetylmuramoyl-L-alanine amidase	A0A067ZJB6	Vibrio_phage	1.5e-15	30.7

DBSCAN-SWA_225

3491967 : 3493455

Mycoplasma_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000762684.1\|3491967_3493455_-	leucyl aminopeptidase	Q6GYZ8	Mycoplasma_phage	6.3e-49	34.4

DBSCAN-SWA_226

3498239 : 3499196

Klosneuvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000627564.1\|3498239_3499196_+	bifunctional riboflavin kinase/FAD synthetase	A0A1V0SJE1	Klosneuvirus	1.4e-09	37.1

DBSCAN-SWA_227

3506989 : 3510004

Acanthocystis_turfacea_Chlorella_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000535417.1\|3506989_3507706_+	aquaporin family protein	M1HJ75	Acanthocystis_turfacea_Chlorella_virus	2.3e-33	38.7
WP_001244294.1\|3508810_3510004_+	M23 family metallopeptidase	A0A2L1IVP0	Streptomyces_phage	1.5e-08	32.6

DBSCAN-SWA_228

3539845 : 3540613

Acanthamoeba_polyphaga_mimivirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000043153.1\|3539845_3540613_-	SDR family oxidoreductase	A0A0G2Y601	Acanthamoeba_polyphaga_mimivirus	6.4e-05	26.8

DBSCAN-SWA_229

3547517 : 3549977

Acinetobacter_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_105291359.1\|3547517_3548665_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	3.7e-41	34.5
WP_002187300.1\|3548843_3549977_+	hypothetical protein	S5W9G5	Leptospira_phage	5.9e-15	69.6

DBSCAN-SWA_230

3553063 : 3559673

Leptospira_phage(75.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002187294.1\|3553063_3554065_+	hypothetical protein	S5W9G5	Leptospira_phage	6.6e-10	65.0
WP_002187287.1\|3554266_3555613_+	hypothetical protein	S5W9G5	Leptospira_phage	1.3e-16	71.8
WP_000692270.1\|3555679_3556531_-	hypothetical protein	S5W9A4	Leptospira_phage	3.2e-106	68.8
WP_082280687.1\|3556642_3556966_-	TIGR04452 family lipoprotein	NA	NA	NA	NA
WP_000123155.1\|3556987_3557611_-	hypothetical protein	NA	NA	NA	NA
WP_139343779.1\|3558531_3559673_-\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.0e-42	37.0

DBSCAN-SWA_231

3568473 : 3571833

Moumouvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000031822.1\|3568473_3570414_+	molecular chaperone DnaK	A0A2P1ELQ7	Moumouvirus	2.0e-143	47.6
WP_000004170.1\|3570714_3571833_+	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	2.4e-24	33.2

DBSCAN-SWA_232

3577357 : 3581213

Planktothrix_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000942282.1\|3577357_3578140_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.5e-38	40.0
WP_002087232.1\|3578421_3578610_+	hypothetical protein	NA	NA	NA	NA
WP_001199942.1\|3578618_3581213_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	2.4e-253	52.7

DBSCAN-SWA_233

3586628 : 3587775

Acinetobacter_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_100218943.1\|3586628_3587775_+\|transposase	IS3-like element IS1500B family transposase	A0A0P0I4A4	Acinetobacter_phage	6.3e-41	34.5

DBSCAN-SWA_234

3604387 : 3605512

Enterobacteria_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000786827.1\|3604387_3605512_+	VWA domain-containing protein	Q9EYF7	Enterobacteria_phage	1.1e-85	52.3

DBSCAN-SWA_235

3645613 : 3645901

Gordonia_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000433083.1\|3645613_3645901_-	HNH endonuclease	A0A2D2W4Q9	Gordonia_phage	6.7e-08	40.9

DBSCAN-SWA_236

3675116 : 3677012

Hokovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000494225.1\|3675116_3677012_-	ATP-dependent DNA helicase RecQ	A0A1V0SGM9	Hokovirus	2.6e-71	32.4

DBSCAN-SWA_237

3701206 : 3703426

uncultured_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002189443.1\|3701206_3703426_-	copper-translocating P-type ATPase	A0A218MNH6	uncultured_virus	8.9e-116	37.6

DBSCAN-SWA_238

3713117 : 3716234

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000952672.1\|3713117_3716234_-	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	2.5e-63	22.5

DBSCAN-SWA_239

3735504 : 3740372

Klosneuvirus(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000626351.1\|3735504_3737094_-	SDR family oxidoreductase	A0A1V0SKJ3	Klosneuvirus	4.8e-39	30.2
WP_105291359.1\|3737335_3738482_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	3.7e-41	34.5
WP_000651726.1\|3739187_3740372_+	adenylate/guanylate cyclase domain-containing protein	A0A218MLZ2	uncultured_virus	1.1e-16	27.4

DBSCAN-SWA_240

3746731 : 3747805

Flamingopox_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188303.1\|3746731_3747805_+	YceK/YidQ family lipoprotein	A0A2H4X2P9	Flamingopox_virus	5.2e-05	37.9

DBSCAN-SWA_241

3755755 : 3759067

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001017333.1\|3755755_3759067_-	efflux RND transporter permease subunit	S5VL66	Leptospira_phage	4.0e-19	21.2

DBSCAN-SWA_242

3797150 : 3798389

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001088659.1\|3797150_3798389_-	NAD(P)/FAD-dependent oxidoreductase	A0A2H4PQX1	Staphylococcus_phage	8.7e-12	41.2

DBSCAN-SWA_243

3820985 : 3822413

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000135128.1\|3820985_3822413_-	hypothetical protein	S5WIY5	Leptospira_phage	6.5e-11	29.3

DBSCAN-SWA_244

3831392 : 3838291

uncultured_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000691480.1\|3831392_3833438_+	guanylate cyclase	A0A218MLZ2	uncultured_virus	3.9e-25	30.8
WP_000866993.1\|3834303_3834927_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_001046745.1\|3835039_3838291_-	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	3.6e-97	26.2

DBSCAN-SWA_245

3846843 : 3848520

Hokovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001098062.1\|3846843_3848520_+	GAF domain-containing hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	3.9e-55	32.1

DBSCAN-SWA_246

3859154 : 3865230

Leptospira_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000838385.1\|3859154_3862268_-	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	1.9e-63	22.6
WP_148636836.1\|3862921_3863875_+	signal peptide peptidase SppA	A0A0K2FHL6	Achromobacter_phage	3.7e-18	30.6
WP_000661083.1\|3863881_3864481_+	hypothetical protein	NA	NA	NA	NA
WP_001023250.1\|3864477_3865230_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.6e-29	35.3

DBSCAN-SWA_247

3893179 : 3894388

Tupanvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188046.1\|3893179_3894388_-	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2K9L470	Tupanvirus	5.7e-32	28.4

DBSCAN-SWA_248

3905873 : 3907028

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188068.1\|3905873_3907028_+	AraC family transcriptional regulator	S5WIW9	Leptospira_phage	1.8e-11	28.2

DBSCAN-SWA_249

3910261 : 3912409

Terra1_virus(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001089002.1\|3910261_3912409_+\|tRNA	methionine--tRNA ligase	F1C981	Terra1_virus	1.7e-55	27.7

DBSCAN-SWA_250

3917821 : 3922917

Volepox_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000688696.1\|3917821_3918787_-	NAD-dependent epimerase/dehydratase family protein	A0A1C9KCG7	Volepox_virus	4.9e-10	22.9
WP_002188030.1\|3919749_3922917_+	efflux RND transporter permease subunit	S5VTK5	Leptospira_phage	7.7e-97	26.0

DBSCAN-SWA_251

3928259 : 3933054

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000172726.1\|3928259_3929243_+	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	5.1e-15	32.0
WP_002163532.1\|3929461_3930418_-	UDP-N-acetylmuramate dehydrogenase	NA	NA	NA	NA
WP_001081088.1\|3931426_3931684_+	hypothetical protein	NA	NA	NA	NA
WP_000506978.1\|3931799_3932495_-	phosphopantothenoylcysteine decarboxylase	Q9HH70	Methanothermobacter_phage	2.2e-12	28.0
WP_000067294.1\|3932511_3933054_-	phosphopantothenoylcysteine decarboxylase	Q9J5A8	Fowlpox_virus	2.5e-19	34.2

DBSCAN-SWA_252

3946174 : 3949718

Tupanvirus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001237888.1\|3946174_3947146_-	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	2.9e-47	38.0
WP_000690880.1\|3947142_3947922_-	acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase	NA	NA	NA	NA
WP_000959560.1\|3948068_3948416_+	Hpt domain-containing protein	NA	NA	NA	NA
WP_001072162.1\|3948785_3949718_+	Fic family protein	A2TEX9	White_spot_syndrome_virus	2.0e-08	29.4

DBSCAN-SWA_253

3953596 : 3955681

Ostreococcus_lucimarinus_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000789319.1\|3953596_3954394_-	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0N7HVJ8	Ostreococcus_lucimarinus_virus	2.9e-45	38.8
WP_000806222.1\|3954377_3954827_-	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_000601181.1\|3954823_3955681_-	ATP-binding protein	S5W9L4	Leptospira_phage	2.7e-81	50.7

DBSCAN-SWA_254

3959236 : 3960259

Acanthocystis_turfacea_Chlorella_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000709511.1\|3959236_3960259_-	GDP-mannose 4,6-dehydratase	M1HGM9	Acanthocystis_turfacea_Chlorella_virus	1.5e-118	61.1

DBSCAN-SWA_255

3973269 : 3975430

Bodo_saltans_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001177028.1\|3973269_3973701_+	SET domain-containing protein	A0A2H4UVV9	Bodo_saltans_virus	7.7e-08	29.8
WP_000572019.1\|3974123_3974912_-	glycerophosphodiester phosphodiesterase	A0A2H4PGQ5	Escherichia_phage	1.3e-13	24.8
WP_000414808.1\|3975046_3975430_-	hypothetical protein	S5WJ36	Leptospira_phage	1.7e-06	32.1

DBSCAN-SWA_256

3987385 : 3989800

Hokovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188685.1\|3987385_3989800_-	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	2.5e-55	33.4

DBSCAN-SWA_257

4000219 : 4001896

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_011172385.1\|4000219_4001896_+	sphingomyelin phosphodiesterase	A0A1P8L6H7	Staphylococcus_phage	2.4e-49	41.6

DBSCAN-SWA_258

4016957 : 4017626

Orpheovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001087013.1\|4016957_4017626_-	RibD family protein	A0A2I2L4R9	Orpheovirus	9.2e-08	22.8

DBSCAN-SWA_259

4030872 : 4037242

uncultured_Caudovirales_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000393265.1\|4030872_4033719_-	DEAD/DEAH box helicase family protein	A0A2H4J643	uncultured_Caudovirales_phage	5.9e-64	28.3
WP_000369357.1\|4033719_4034433_-	4Fe-4S cluster-binding domain-containing protein	L7TNL1	Halovirus	8.6e-12	25.9
WP_002105467.1\|4034927_4035830_+	lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase	NA	NA	NA	NA
WP_000230383.1\|4036365_4036545_-	hypothetical protein	NA	NA	NA	NA
WP_000233562.1\|4036705_4037242_-	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	4.9e-20	37.3

DBSCAN-SWA_260

4044895 : 4046446

Diachasmimorpha_longicaudata_entomopoxvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000734111.1\|4044895_4046446_+	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	2.6e-69	39.8

DBSCAN-SWA_261

4080033 : 4081506

Mollivirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000086941.1\|4080033_4081506_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.6e-50	31.2

DBSCAN-SWA_262

4088396 : 4090479

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000795919.1\|4088396_4089098_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.8e-38	35.7
WP_001254665.1\|4089087_4090479_+	HAMP domain-containing protein	W8CYF6	Bacillus_phage	1.5e-28	32.5

DBSCAN-SWA_263

4105409 : 4108445

Pseudomonas_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001124828.1\|4105409_4107455_-	DNA ligase (NAD(+)) LigA	A0A1Y0SYX1	Pseudomonas_phage	8.6e-73	31.4
WP_000409996.1\|4107473_4108445_-	peptidoglycan DD-metalloendopeptidase family protein	D7RWE0	Brochothrix_phage	7.5e-19	41.1

DBSCAN-SWA_264

4120626 : 4121154

Red_sea_bream_iridovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001060300.1\|4120626_4121154_+	O-acetyl-ADP-ribose deacetylase	F1SVT2	Red_sea_bream_iridovirus	1.5e-29	42.0

DBSCAN-SWA_265

4137969 : 4138995

Orpheovirus(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001053743.1\|4137969_4138995_-\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2I2L4E3	Orpheovirus	1.5e-30	34.6

DBSCAN-SWA_266

4144837 : 4145767

Staphylococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000598571.1\|4144837_4145767_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.1e-30	37.7

DBSCAN-SWA_267

4161508 : 4162414

uncultured_Mediterranean_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000681221.1\|4161508_4161991_+	pantetheine-phosphate adenylyltransferase	A0A1B1IVQ3	uncultured_Mediterranean_phage	2.9e-27	39.5
WP_000091691.1\|4162000_4162414_+	nucleoside-diphosphate kinase	A0A2K9L595	Tupanvirus	3.1e-14	32.6

DBSCAN-SWA_268

4167016 : 4168552

Hokovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001288620.1\|4167016_4168552_-	PAS domain S-box protein	A0A1V0SGR3	Hokovirus	1.9e-08	26.0

DBSCAN-SWA_269

4183807 : 4187328

Vibrio_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001972951.1\|4183807_4185196_+	DNA gyrase subunit A	A0A126HHL9	Vibrio_phage	2.3e-37	28.8
WP_000102225.1\|4185192_4187328_+	DNA gyrase subunit B	W8JPL8	Salmonella_phage	1.6e-42	27.0

DBSCAN-SWA_270

4190927 : 4192277

Phaeocystis_globosa_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188008.1\|4190927_4192277_-	FAD-dependent oxidoreductase	R4THQ7	Phaeocystis_globosa_virus	7.8e-06	40.7

DBSCAN-SWA_271

4208096 : 4209017

Bacillus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000858301.1\|4208096_4209017_+	M23 family metallopeptidase	A0A1D6X855	Bacillus_phage	2.4e-14	41.1

DBSCAN-SWA_272

4213258 : 4214509

Hokovirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000365065.1\|4213258_4214509_-	sulfate adenylyltransferase	A0A1V0SGC3	Hokovirus	9.7e-35	27.7

DBSCAN-SWA_273

4225676 : 4227628

Planktothrix_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000218838.1\|4225676_4226678_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.0e-18	35.0
WP_000619173.1\|4226674_4227628_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	9.0e-25	37.8

DBSCAN-SWA_274

4231135 : 4232968

Tetraselmis_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188051.1\|4231135_4232968_-	MutS domain V protein	A0A2P0VN50	Tetraselmis_virus	3.6e-14	27.1

DBSCAN-SWA_275

4238038 : 4239631

uncultured_Caudovirales_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188010.1\|4238038_4239631_-	methyl-accepting chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	5.2e-09	37.1

DBSCAN-SWA_276

4244060 : 4244870

Saudi_moumouvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000008116.1\|4244060_4244870_+	alpha/beta hydrolase	A0A1S5V1I6	Saudi_moumouvirus	2.9e-16	30.6

DBSCAN-SWA_277

4251015 : 4253631

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001133817.1\|4251015_4253001_-	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.5e-85	39.2
WP_000390685.1\|4253079_4253631_-	GTP cyclohydrolase I FolE	A0A0P0HSD2	Acinetobacter_phage	2.0e-48	53.4

DBSCAN-SWA_278

4257898 : 4258858

Synechococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001003557.1\|4257898_4258858_-	NAD(P)-dependent oxidoreductase	M4QPK0	Synechococcus_phage	1.9e-06	26.3

DBSCAN-SWA_279

4285686 : 4286634

Anomala_cuprea_entomopoxvirus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001052495.1\|4285686_4286634_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	3.4e-24	28.2

DBSCAN-SWA_280

4292742 : 4293294

uncultured_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000723581.1\|4292742_4293294_+	hypoxanthine phosphoribosyltransferase	A0A218MMB5	uncultured_virus	5.2e-17	30.4

DBSCAN-SWA_281

4296546 : 4297032

Molluscum_contagiosum_virus(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002070182.1\|4296546_4297032_-	glutathione peroxidase	A0A1S7DMQ0	Molluscum_contagiosum_virus	9.9e-12	34.1

DBSCAN-SWA_282

4303063 : 4303318

Vibrio_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000960595.1\|4303063_4303318_-	carbon storage regulator CsrA	A0A2I7RT00	Vibrio_phage	1.0e-07	43.9

DBSCAN-SWA_283

4308775 : 4309852

Planktothrix_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001973139.1\|4308775_4309852_+	M23 family metallopeptidase	G9BW84	Planktothrix_phage	4.0e-13	38.0

DBSCAN-SWA_284

4325725 : 4327165

Pneumococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000929209.1\|4325725_4327165_+	DNA polymerase III subunit gamma/tau	E7DN81	Pneumococcus_phage	2.2e-43	36.2

DBSCAN-SWA_285

4333370 : 4334624

uncultured_Mediterranean_phage(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000886261.1\|4333370_4334624_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	4.7e-82	48.4

DBSCAN-SWA_286

4339254 : 4340894

Leptospira_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001185518.1\|4339254_4340130_-	ParB/RepB/Spo0J family partition protein	S5WII0	Leptospira_phage	6.6e-22	44.1
WP_000516556.1\|4340132_4340894_-	ParA family protein	Q8JL10	Natrialba_phage	7.4e-22	29.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_CP043040

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

13295 : 27170

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002188275.1\|13295_20399_-	RHS repeat-associated core domain protein	S5VY91	Leptospira_phage	5.9e-278	32.2
WP_002188287.1\|20834_21719_+	hypothetical protein	S5VSU6	Leptospira_phage	5.8e-135	81.0
WP_082280711.1\|21784_23086_+	hypothetical protein	S5VKK9	Leptospira_phage	3.7e-223	86.8
WP_002188291.1\|23095_23719_+	tetratricopeptide repeat protein	S5VKQ0	Leptospira_phage	8.2e-51	57.5
WP_002188267.1\|23901_25335_-	hypothetical protein	S5W9F7	Leptospira_phage	2.5e-167	66.9
WP_000818560.1\|25804_26434_-	DUF3102 domain-containing protein	NA	NA	NA	NA
WP_000691796.1\|26417_27170_-	AAA family ATPase	Q9G093	Leptospira_phage	3.0e-23	34.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage