CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP041996	Escherichia coli strain AR Bank #0349 chromosome, complete genome	2 crisprs	cas3,csa3,PD-DExK,c2c9_V-U4,DEDDh,DinG	0	4	9	0
NZ_CP041997	Escherichia coli strain AR Bank #0349 plasmid pAR349, complete sequence	0 crisprs	csa3	0	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP041996_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041996_1

3543150-3543263

Orphan

Consensus_repeat	Method
TTTTTTTACCTGATTCGGGTAAA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP041996_1

>merge|NZ_CP041996|1|3543150-3543263|PILER-CR
TTTACCTGATTCGGGTAAACGTCTTTACCTGATTTGGGTAAACTTTTTTTACCTGATTCAGGTAAATTTACCTCTTTCAGGTAAACTTTATTTTTCTTACCTGATTCGGGTAAT

>NZ_CP041996|1|1|3543150-3543263|PILER-CR
TTTACCTGATTCGGGTAAACGTC	TTTACCTGATTTGGGTAAACTTTT
TTTACCTGATTCAGGTAAATTTA	CCTCTTTCAGGTAAACTTTATTTTT
CTTACCTGATTCGGGTAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041996.1\|WP_032139864.1\|3541087_3541195_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041996.1\|WP_061092794.1\|3543699_3544239_-\|regulator	unknown	unknown	gnl\|CDD\|368819
NZ_CP041996.1\|WP_052953584.1\|3547283_3548069_+\|phage-recombination-protein-Bet	unknown	unknown	gnl\|CDD\|273871
NZ_CP041996.1\|WP_045173744.1\|3548742_3548901_+\|DUF1317-family-protein	unknown	unknown	gnl\|CDD\|284449
NZ_CP041996.1\|WP_064767403.1\|3544655_3545345_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225484
NZ_CP041996.1\|WP_000145912.1\|3541686_3541989_-\|protein-ren	unknown	unknown	unknown
NZ_CP041996.1\|WP_001067459.1\|3544320_3544551_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|374243
NZ_CP041996.1\|WP_000224919.1\|3537118_3537289_-\|NinE-family-protein	unknown	unknown	gnl\|CDD\|182029
NZ_CP041996.1\|WP_061092790.1\|3546699_3546906_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236900
NZ_CP041996.1\|WP_000068668.1\|3537940_3538870_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041996.1\|WP_061092792.1\|3545425_3545695_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041996.1\|WP_001567061.1\|3539074_3539392_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371129
NZ_CP041996.1\|WP_001309322.1\|3537740_3537842_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041996.1\|WP_061092791.1\|3545826_3546144_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041996.1\|WP_000995439.1\|3546981_3547278_+\|host-nuclease-inhibitor-protein-Gam	unknown	unknown	gnl\|CDD\|368728
NZ_CP041996.1\|WP_001053033.1\|3537288_3537744_-\|DNA-base-flipping-protein-YbcN	unknown	unknown	gnl\|CDD\|182057
NZ_CP041996.1\|WP_001566186.1\|3541985_3542687_-\|replication-protein-P	unknown	unknown	gnl\|CDD\|369163
NZ_CP041996.1\|WP_024228451.1\|3548065_3548746_+\|YqaJ-viral-recombinase-family-protein	unknown	unknown	gnl\|CDD\|378216
NZ_CP041996.1\|WP_000709069.1\|3539503_3541030_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|238206
NZ_CP041996.1\|WP_001070442.1\|3541286_3541619_-\|SMR-family-multidrug-efflux-protein-EmrE	unknown	unknown	gnl\|CDD\|137367

Protein	Function_ID	Function_description	E-value
NZ_CP041996.1\|WP_061092794.1\|3543699_3544239_-\|regulator	gnl\|CDD\|368819	pfam06254, YdaT_toxin, Putative bacterial toxin ydaT. YdaT_toxin is a family of putative bacterial toxins that are neutralized by the putative antitoxin YdaS, UniProtKB:P76063, family pfam144549.	1.29366e-37
NZ_CP041996.1\|WP_052953584.1\|3547283_3548069_+\|phage-recombination-protein-Bet	gnl\|CDD\|273871	TIGR01913, Uncharacterized_protein_UU154, phage recombination protein Bet. This model represents the phage recombination protein Bet from a number of phage, including phage lambda. All members of this family are found in phage genomes or in putative prophage regions of bacterial genomes. [Mobile and extrachromosomal element functions, Prophage functions].	7.63163e-65
NZ_CP041996.1\|WP_045173744.1\|3548742_3548901_+\|DUF1317-family-protein	gnl\|CDD\|284449	pfam07026, DUF1317, Protein of unknown function (DUF1317). This family consists of several hypothetical bacterial and phage proteins of around 60 residues in length. The function of this family is unknown.	2.69023e-30
NZ_CP041996.1\|WP_064767403.1\|3544655_3545345_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225484	COG2932, COG2932, Predicted transcriptional regulator [Transcription].	1.13104e-28
NZ_CP041996.1\|WP_000224919.1\|3537118_3537289_-\|NinE-family-protein	gnl\|CDD\|182029	PRK09689, PRK09689, prophage protein NinE; Provisional.	5.23624e-25
NZ_CP041996.1\|WP_061092790.1\|3546699_3546906_+\|hypothetical-protein	gnl\|CDD\|236900	PRK11354, kil, FtsZ inhibitor protein; Reviewed.	1.47433e-13
NZ_CP041996.1\|WP_001567061.1\|3539074_3539392_-\|hypothetical-protein	gnl\|CDD\|371129	pfam10548, P22_AR_C, P22AR C-terminal domain. This domain was identified by Iyer and colleagues. It is found associated with pfam10547.	1.45869e-10
NZ_CP041996.1\|WP_000709069.1\|3539503_3541030_-\|recombinase-family-protein	gnl\|CDD\|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	5.44151e-26
NZ_CP041996.1\|WP_001053033.1\|3537288_3537744_-\|DNA-base-flipping-protein-YbcN	gnl\|CDD\|182057	PRK09741, PRK09741, hypothetical protein; Provisional.	8.87333e-95
NZ_CP041996.1\|WP_000995439.1\|3546981_3547278_+\|host-nuclease-inhibitor-protein-Gam	gnl\|CDD\|368728	pfam06064, Gam, Host-nuclease inhibitor protein Gam. The Gam protein inhibits RecBCD nuclease and is found in both bacteria and bacteriophage.	8.40476e-53
NZ_CP041996.1\|WP_001566186.1\|3541985_3542687_-\|replication-protein-P	gnl\|CDD\|369163	pfam06992, Phage_lambda_P, Replication protein P. This family consists of several Bacteriophage lambda replication protein P like proteins. The bacteriophage lambda P protein promoters replication of the phage chromosome by recruiting a key component of the cellular replication machinery to the viral origin. Specifically, P protein delivers one or more molecules of Escherichia coli DnaB helicase to a nucleoprotein structure formed by the lambda O initiator at the lambda replication origin.	1.39958e-81
NZ_CP041996.1\|WP_024228451.1\|3548065_3548746_+\|YqaJ-viral-recombinase-family-protein	gnl\|CDD\|378216	pfam09588, YqaJ, YqaJ-like viral recombinase domain. This protein family is found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms part of the two-component SynExo viral recombinase functional unit.	3.21152e-29
NZ_CP041996.1\|WP_001067459.1\|3544320_3544551_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|374243	pfam15943, YdaS_antitoxin, Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT. YdaS_antitoxin is a family of putative bacterial antitoxins, neutralising the toxin YdaT, family pfam06254.	2.82645e-22
NZ_CP041996.1\|WP_001070442.1\|3541286_3541619_-\|SMR-family-multidrug-efflux-protein-EmrE	gnl\|CDD\|137367	PRK09541, emrE, EmrE family multidrug efflux SMR transporter.	2.58749e-62

>NZ_CP041996.1|WP_001566186.1|3541985_3542687_-|replication-protein-P
MKNIAAQMINFDREQMRRIANNMPEQYDEKPQVQQVAQIINGVFSQLLATFPASLANRDQNELNEIRRQWVLAFRENGITTMEQVNAGMRVARRQNRPFLPSPGQFVAWCREEVSVIAGLPNASELVDMVYEYCRKRGLYPDAESYPWKSNAHYWLVTSLYQNMRANALTDTELRRKAADELTCMTARINRGEAIPEPVKQLPVMGGRPLNRAQALAKIAEIKAKFGLKGASV
>NZ_CP041996.1|WP_000145912.1|3541686_3541989_-|protein-ren
MTGKEAIIHYLGTHKSFCAQDVAAVTGATVTSINQAAAKMARAGILVVDGKVWRTVYYRFATREEREGKVSTNLIFKECRQSAAMKRLLRVYKRTSMGTQ
>NZ_CP041996.1|WP_001070442.1|3541286_3541619_-|SMR-family-multidrug-efflux-protein-EmrE
MNPYIYLGGAILAEVIGTTLMKFSEGFTRLWPSVGTIICYCASFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQRLDLPAIIGMMLICAGVLVINLLSRSTPH
>NZ_CP041996.1|WP_032139864.1|3541087_3541195_-|hypothetical-protein
MYSFVLSRLWRKKIAIRLLLYIQDNVTLIVFLNKN
>NZ_CP041996.1|WP_000709069.1|3539503_3541030_-|recombinase-family-protein
MKKAIAYMRFSSPGQMSGDSLNRQRRLIAEWLKVNSDYYLDTITYEDLGLSAFKGKHAQSGAFSEFLDAIEHGYILPGTTLLVESLDRLSREKVGEAIERLKLILNHGIDVITLCDNTVYNIDSLNDPYSLIKAILIAQRANEESEIKSSRVKLSWKKKRQDALESGTIMTASCPRWLSLDDKRTAFVPDPDRVKTIELIFKLRMERRSLNAIAKYLNDHAVKNFSGKESAWGPSVIEKLLANKALIGICVPSYRARGKGISEIAGYYPRVISDDLFYAVQEIRLAPFGISNSSKNPMLINLLRTVMKCEACGNTMIVHAVSGSLHGYYVCPMRRLHRCDRPSIKRDLVDYNIINELLFNCSKIQPVENKKDANETLELKIIELQMKINNLIAALSVAPEVTAIAEKIRVLDKELRRASVSLKTLKSKAVSSLGDFHAIDLTSKNGRELCRTLAYKTFEKIIINTDNKTCDIYFMNGIVFKHYPLMKTISAQQAISTLKYMVDGEVYF
>NZ_CP041996.1|WP_001567061.1|3539074_3539392_-|hypothetical-protein
MDAGVLVLAVQQSPITKQFTDNELCTLAWLWRAGNVMLIAYQNVTHLLQDAEHGEAGHFTSIEQEYPQILNRARAILVRETAHVKLQPWQDDKWSRVLPYLRQIC
>NZ_CP041996.1|WP_000068668.1|3537940_3538870_-|hypothetical-protein
MAQQRTTSLRSIPLDLDVKQEAVINGIEMGVLDNGIPYLTQNGLANVCGVQRLRIKEITDEWAQSVENGIFKKGRMTFIGTYLLNEGFTDEKLYIPIIRNGVEYHAYPDVVCMAILEYYAFEAKQAESETAIRSYRELAKKGLKTFIYEALKYQPEDPWRHYHDRVSLLKDKGTIPDGYFIIFNEIAGMMVDLINAGLAINQHTVPDGSVGSCWARHWKAKGLATEFGERVDCEHYYPEDFLQASSNPQIINAYPDSALSEFRRWFKHEYLTTKFPPYILKKSNVLPGGTEDANRLIEAFKKSELENKP
>NZ_CP041996.1|WP_001309322.1|3537740_3537842_-|hypothetical-protein
MRTYNPNSLLPSQMQRCTCDFLHPAFDLCGGEA
>NZ_CP041996.1|WP_001053033.1|3537288_3537744_-|DNA-base-flipping-protein-YbcN
MNLPQDGIKLHRGNFTAIGRQIQPYLEEGKCFRMVLKPWREKRSLSQNALSHMWYSEISEYLINRGKTFATPAWVKDALKHTYLGYETKDLVDVVTGDITTIQSLRHTSDLDTGEMYVFLCKVEAWAVNIGCHLTIPQSCEFQLLRDKQEA
>NZ_CP041996.1|WP_000224919.1|3537118_3537289_-|NinE-family-protein
MATPLIRVMNGHIYRVSNRRKRKPEPKPSEIPTLLGYTASLVDKKWLRLAARRNHG
>NZ_CP041996.1|WP_061092794.1|3543699_3544239_-|regulator
MQPITYQQTSGFTPTAVINRSQTKQAPGHEKIRDAVRAWSAADNQDVVAALIVNEYRELGGGTIDFPDDVSRARQKLFRFLDNKFDSEKYRNNVRELTPAILAVLPLEYRGYLVEQDSFMARLAEMEKELSEAKQAVILNAPRHQKLKEISEGIVSMFRVDPDLAGPLMAMVTTMLGAI
>NZ_CP041996.1|WP_001067459.1|3544320_3544551_-|helix-turn-helix-domain-containing-protein
MNPAIKTAINIVGSQKKLGDACEVSQQAVYKWLHNKAKVSPEHVGSIVTATGGVVKAYQIRPDLPKLFPHTEKNAA
>NZ_CP041996.1|WP_064767403.1|3544655_3545345_+|helix-turn-helix-transcriptional-regulator
MKTTLSERLKEARSARGLTQKALGDLVGVSQAAIQKIETGKANQTTKIVEIANALGVRAEWLSSGIGNMSDSTVQPIQSTLSHSKYFKIDVLDIEVSAGPGVINREFVEVLRSVEYSFDDARHMFDGRKAENIRIINVRGDSMSGTIEPGDLLFVDITVKSFDGDGIYAFLYDDTAHVKRLQMMKDKLLVISDNKSYSPWDPIEKDEMNRVFIFGKVIGSMPQTYRKHG
>NZ_CP041996.1|WP_061092792.1|3545425_3545695_+|hypothetical-protein
MSDKKLIKKSNNCVDAYADAFGYSSFGEDDDRLGSISFFQHVTEWDADGSNDTESVKYNIATIRMTEDLMLKLADFIRDQHDRAKTNKS
>NZ_CP041996.1|WP_061092791.1|3545826_3546144_+|hypothetical-protein
MLQSSGSGGSGSNNVLESKVAKLESDVSYIRRDVDELKTDVKSIDRNMIAVLERLDSIKESLAKKPSIDAIDKKISDAKLAVLLGVPAIIAAGTGLYKLSMYFFL
>NZ_CP041996.1|WP_061092790.1|3546699_3546906_+|hypothetical-protein
MVHQHYGTQTVNRGAVMPGMLVKHKDGTWTASANLRGRLYLHRGVERTYTRDLLVEIFLDGRGNGLNH
>NZ_CP041996.1|WP_000995439.1|3546981_3547278_+|host-nuclease-inhibitor-protein-Gam
MNAYYIQDRLEAQSWARHYQQIAREEKEAELADDMEKGLPQHLFESLCIDHLQRHGASKKAITRAFDDDVEFQERMAEHIRYMVETIAHHQVDIDSEV
>NZ_CP041996.1|WP_052953584.1|3547283_3548069_+|phage-recombination-protein-Bet
MSTALATLAGKLAERVGMDSVDPQELITTLRQTAFKGDASDAQFIALLIVANQYGLNPWTKEIYAFPDKQNGIVPVVGVDGWSRIINENQQFDGMDFEQDNESCTCRIYRKDRNHPICVTEWMDECRREPFKTREGREITGPWQSHPKRMLRHKAMIQCARLAFGFAGIYDKDEAERIVENTAYTAEHQPERDITPVNDETMQEINTLLIALDKTWDDDLLPLCSQIFRRDIRASSELTQAEAVKALGFLKQKATEQKVAA
>NZ_CP041996.1|WP_024228451.1|3548065_3548746_+|YqaJ-viral-recombinase-family-protein
MTPDIILQRTGIDVRAVEQGDDAWHKLRLGVITASEVHNVIAKPRSGKKWPDMKMSYFHTLLAEVCTGVAPEVNAKALAWGKQYENDARTLFEFTSGVNVTESPIIYRDESMRTACSPDGLCSDGNGLELKCPFTSRDFMKFRLGGFEAIKSAYMAQVQYSMWVTRKDAWYFSNYDPRMKREGLHYVVVERDEKYMASFDEMVPEFIEKMDEALAEIGFVFGEQWR
>NZ_CP041996.1|WP_045173744.1|3548742_3548901_+|DUF1317-family-protein
MTHPHDNIRVGAITFVYSITKRGWVFPGLSVIRNPLKAQRLAEEINNKRGAV

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Crispr_ID: NZ_CP041996_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP041996_2

4055658-4055790

Orphan

Consensus_repeat	Method
ATCACCAATATTGAAAA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP041996_2

>merge|NZ_CP041996|2|4055658-4055790|PILER-CR
ATCACCAATATTGAAAATGTCACACGCAGATAAATCCAACTTTCAATATTGTTAAGCTCCTCACCAATATTGAAAACATGGCGTAGCAAAAAGAAATTTTCAATATTGTTTTATGGATCACCAATATTGAAAG

>NZ_CP041996|2|2|4055658-4055790|PILER-CR
ATCACCAATATTGAAAA	TGTCACACGCAGATAAATCCAACTTTCAATATTGTTAAGCTC
CTCACCAATATTGAAAA	CATGGCGTAGCAAAAAGAAATTTTCAATATTGTTTTATGG
ATCACCAATATTGAAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP041996.1\|WP_000787109.1\|4056039_4057554_+\|L-carnitine/gamma-butyrobetaine-antiport-BCCT-transporter	unknown	unknown	gnl\|CDD\|179568
NZ_CP041996.1\|WP_000347117.1\|4057584_4058727_+\|crotonobetainyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|179566
NZ_CP041996.1\|WP_000122898.1\|4062599_4063190_+\|carnitine-operon-protein-CaiE	unknown	unknown	gnl\|CDD\|184189
NZ_CP041996.1\|WP_001091512.1\|4053840_4054782_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|235120
NZ_CP041996.1\|WP_001183208.1\|4050830_4052162_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340874
NZ_CP041996.1\|WP_001126358.1\|4063964_4067186_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
NZ_CP041996.1\|WP_000600725.1\|4050192_4050723_-\|glutathione-regulated-potassium-efflux-system-oxidoreductase-KefF	unknown	unknown	gnl\|CDD\|234852
NZ_CP041996.1\|WP_001361348.1\|4061808_4062594_+\|crotonobetainyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|179599
NZ_CP041996.1\|WP_001361347.1\|4060146_4061700_+\|crotonobetaine/carnitine-CoA-ligase	unknown	unknown	gnl\|CDD\|181195
NZ_CP041996.1\|WP_000377112.1\|4048337_4050200_-\|glutathione-regulated-potassium-efflux-system-protein-KefC	unknown	unknown	gnl\|CDD\|235131
NZ_CP041996.1\|WP_001287712.1\|4052503_4053790_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|182273
NZ_CP041996.1\|WP_061092952.1\|4046900_4047350_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP041996.1\|WP_000692225.1\|4054796_4055567_-\|electron-transfer-flavoprotein	unknown	unknown	gnl\|CDD\|179569
NZ_CP041996.1\|WP_000543585.1\|4068807_4069629_-\|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl\|CDD\|223366
NZ_CP041996.1\|WP_000624375.1\|4047666_4048146_-\|type-3-dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|182714
NZ_CP041996.1\|WP_000203741.1\|4052219_4052507_-\|ferredoxin-like-protein-FixX	unknown	unknown	gnl\|CDD\|185346
NZ_CP041996.1\|WP_061092953.1\|4047466_4047646_-\|antitoxin	unknown	unknown	gnl\|CDD\|227619
NZ_CP041996.1\|WP_001361349.1\|4067203_4068352_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
NZ_CP041996.1\|WP_000349940.1\|4058855_4060073_+\|L-carnitine-CoA-transferase	unknown	unknown	gnl\|CDD\|179589
NZ_CP041996.1\|WP_000333125.1\|4063308_4063704_-\|carnitine-metabolism-transcriptional-regulator-CaiF	unknown	unknown	gnl\|CDD\|183154

Protein	Function_ID	Function_description	E-value
NZ_CP041996.1\|WP_000787109.1\|4056039_4057554_+\|L-carnitine/gamma-butyrobetaine-antiport-BCCT-transporter	gnl\|CDD\|179568	PRK03356, PRK03356, L-carnitine/gamma-butyrobetaine antiport BCCT transporter.	0
NZ_CP041996.1\|WP_000347117.1\|4057584_4058727_+\|crotonobetainyl-CoA-dehydrogenase	gnl\|CDD\|179566	PRK03354, PRK03354, crotonobetainyl-CoA dehydrogenase; Validated.	0
NZ_CP041996.1\|WP_000122898.1\|4062599_4063190_+\|carnitine-operon-protein-CaiE	gnl\|CDD\|184189	PRK13627, PRK13627, carnitine operon protein CaiE; Provisional.	4.46912e-141
NZ_CP041996.1\|WP_001091512.1\|4053840_4054782_-\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|235120	PRK03363, fixB, electron transfer flavoprotein subunit alpha/FixB family protein.	0
NZ_CP041996.1\|WP_001183208.1\|4050830_4052162_-\|MFS-transporter	gnl\|CDD\|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.50697e-58
NZ_CP041996.1\|WP_001126358.1\|4063964_4067186_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
NZ_CP041996.1\|WP_000600725.1\|4050192_4050723_-\|glutathione-regulated-potassium-efflux-system-oxidoreductase-KefF	gnl\|CDD\|234852	PRK00871, PRK00871, glutathione-regulated potassium-efflux system oxidoreductase KefF.	2.99389e-133
NZ_CP041996.1\|WP_001361348.1\|4061808_4062594_+\|crotonobetainyl-CoA-hydratase	gnl\|CDD\|179599	PRK03580, PRK03580, crotonobetainyl-CoA hydratase.	2.14333e-178
NZ_CP041996.1\|WP_001361347.1\|4060146_4061700_+\|crotonobetaine/carnitine-CoA-ligase	gnl\|CDD\|181195	PRK08008, caiC, putative crotonobetaine/carnitine-CoA ligase; Validated.	0
NZ_CP041996.1\|WP_000377112.1\|4048337_4050200_-\|glutathione-regulated-potassium-efflux-system-protein-KefC	gnl\|CDD\|235131	PRK03562, PRK03562, glutathione-regulated potassium-efflux system protein KefC; Provisional.	0
NZ_CP041996.1\|WP_001287712.1\|4052503_4053790_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|182273	PRK10157, PRK10157, putative oxidoreductase FixC; Provisional.	0
NZ_CP041996.1\|WP_000692225.1\|4054796_4055567_-\|electron-transfer-flavoprotein	gnl\|CDD\|179569	PRK03359, PRK03359, putative electron transfer flavoprotein FixA; Reviewed.	7.20746e-170
NZ_CP041996.1\|WP_000543585.1\|4068807_4069629_-\|4-hydroxy-tetrahydrodipicolinate-reductase	gnl\|CDD\|223366	COG0289, DapB, Dihydrodipicolinate reductase [Amino acid transport and metabolism].	1.6349e-141
NZ_CP041996.1\|WP_000624375.1\|4047666_4048146_-\|type-3-dihydrofolate-reductase	gnl\|CDD\|182714	PRK10769, folA, type 3 dihydrofolate reductase.	1.07206e-127
NZ_CP041996.1\|WP_000203741.1\|4052219_4052507_-\|ferredoxin-like-protein-FixX	gnl\|CDD\|185346	PRK15449, PRK15449, ferredoxin-like protein FixX; Provisional.	1.84173e-69
NZ_CP041996.1\|WP_061092953.1\|4047466_4047646_-\|antitoxin	gnl\|CDD\|227619	COG5302, COG5302, Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only].	7.0453e-07
NZ_CP041996.1\|WP_001361349.1\|4067203_4068352_-\|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
NZ_CP041996.1\|WP_000349940.1\|4058855_4060073_+\|L-carnitine-CoA-transferase	gnl\|CDD\|179589	PRK03525, PRK03525, L-carnitine CoA-transferase.	0
NZ_CP041996.1\|WP_000333125.1\|4063308_4063704_-\|carnitine-metabolism-transcriptional-regulator-CaiF	gnl\|CDD\|183154	PRK11476, PRK11476, carnitine metabolism transcriptional regulator CaiF.	1.42176e-74

>NZ_CP041996.1|WP_000692225.1|4054796_4055567_-|electron-transfer-flavoprotein
MKIITCYKCVPDEQDIAVNNADGSLDFSKADAKISQYDLNAIEAACQLKQQAAEGQVTALSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQQTASALAAAAQKAGFDLILCGDGSSDLYAQQVGLLVGEILNIPAVNGVSKIISLTADTLTVERELEDETETLSIPLPAVVAVSTDINSPQIPSMKAILGAAKKPVQVWSAADIGFNAEAAWSEQQVAAPKQRERQRIVIEGDGEEQIAAFAENLRKVI
>NZ_CP041996.1|WP_001091512.1|4053840_4054782_-|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MNTFSQVWVFSDTPSRLPELMNGAQALANQINTFVLNDADGAQAIQLGANHVWKLSGKPDERMIEDYAGVMADTIRQHGADGLVLLPNTRRGKLLAAKLGYRLKAAVSNDASTVSVQDGKATVKHMVYGGLAIGEERIATPYAVLTISSGTFDVAQPDASRTGETHTVEWQAPAVAITRTATQARQSNSVDLDKARLVVSVGRGIGSKENIALAEQLCKAIGAELACSRPVAENEKWMEHERYVGISNLMLKPELYLAVGISGQIQHMVGANASQTIFAINKDKNAPIFQYADYGIVGDAVKILPALTAALAR
>NZ_CP041996.1|WP_001287712.1|4052503_4053790_-|FAD-dependent-oxidoreductase
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFADSAPVERLITHEKLAFMTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCGLHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLAIAAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDMRMYQKLPAFLDNPRMFNGYPELAVGVARDLFTIDGSAPELMRKKILRHGKKVGFINLIKDGMKGVTVL
>NZ_CP041996.1|WP_000203741.1|4052219_4052507_-|ferredoxin-like-protein-FixX
MTSPVNVDVKLGVNKFNVDEEHPHIVVKADADKQALELLVKACPAGLYKKQDDGSVRFDYAGCLECGTCRILGLGSALEQWEYPRGTFGVEFRYG
>NZ_CP041996.1|WP_001183208.1|4050830_4052162_-|MFS-transporter
MQPSRNFDDLKFSSIHRRILLWGSGGPFLDGYVLVMIGVALEQLTPALKLDADWIGLLGAGTLAGLFVGTSLFGYISDKVGRRKMFLIDIIAIGVISVATMFVSSPVELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWLYDVEGGWRWMLGSAAIPCLLILIGRFELPESPRWLLRKGRVKECEEMMIKLFGEPVAFEEEQPQQTRFRDLFNRRHFPFVLFVAAIWTCQVIPMFAIYTFGPQIVGLLGLGVGKNAALGNVVISLFFMLGCIPPMLWLNTAGRRPLLIGSFAMMTLALAVLGLIPDMGIWLVVMAFAVYAFFSGGPGNLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVSTWALPIFINNYGISSTMLMGAGISLFGLLISVAFAPETRGMSLAQTSNMTIRGQRMG
>NZ_CP041996.1|WP_000600725.1|4050192_4050723_-|glutathione-regulated-potassium-efflux-system-oxidoreductase-KefF
MILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVFSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
>NZ_CP041996.1|WP_000377112.1|4048337_4050200_-|glutathione-regulated-potassium-efflux-system-protein-KefC
MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAAVFGGGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAIPLVAMIPLLAASSASTTMGAFALSALKVAGALALVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLSMAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQVPNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQPRVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQLTEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAMVENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS
>NZ_CP041996.1|WP_000624375.1|4047666_4048146_-|type-3-dihydrofolate-reductase
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
>NZ_CP041996.1|WP_061092953.1|4047466_4047646_-|antitoxin
MNDKTSDFTSERDFVSRTHCVGLNPQATLQWTEVNEDAISALNELAEETGCFSDEYRKF
>NZ_CP041996.1|WP_061092952.1|4046900_4047350_+|hypothetical-protein
MRQINAGLNTREIILEMIDEADDPPFAEQRTWHRRRIAFLCECISVAVDYGFFCSVSQQSIMNITRMAEDVWITESKTTQLIDIWQQLKQLYPPETIPYTQQLPAKELLELLLSSPDDLRIIEIPDIIGDVFDDQTWIRLFKKHFADVI
>NZ_CP041996.1|WP_000787109.1|4056039_4057554_+|L-carnitine/gamma-butyrobetaine-antiport-BCCT-transporter
MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLMDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
>NZ_CP041996.1|WP_000347117.1|4057584_4058727_+|crotonobetainyl-CoA-dehydrogenase
MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEHGGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMWNSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVYTEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEAAWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVSGGSDEMQILTLGRAVLKQYR
>NZ_CP041996.1|WP_000349940.1|4058855_4060073_+|L-carnitine-CoA-transferase
MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLYKCADGYIVMELVGITQIAECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYMARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
>NZ_CP041996.1|WP_001361347.1|4060146_4061700_+|crotonobetaine/carnitine-CoA-ligase
MDIIGGQHLRQMWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQLRHICLTDVALPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQVQKYRATITECIPMMIRTLMVQPPSANDQQHRLREVMFYLNLSAQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRAGFCYEAEIRDDHNRPLPAGEIGEICIKGVPGKTIFKEYFLNPKATAKVLEADGWLHTGDTGYRDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFRFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIRKNLK
>NZ_CP041996.1|WP_001361348.1|4061808_4062594_+|crotonobetainyl-CoA-hydratase
MSESLHLTRNGSILEITLDRPKANAIDAKTSFEMGEVFLNFRDDPQLRVAIITGAGEKFFSAGWDLKAAAEGEAPDADFGPGGFAGLTEIFNLDKPVIAAVNGYAFGGGFELALAADFIVCADNASFALPEAKLGIVPDSGGVLRLPKILPPAIVNEMVMTGRRMGAEEALRWGVVNRVVSQAELMDNARELAQQLVNSAPLAIAALKEIYRTTSEMPVEEAYRYIRSGVLKNYPSVLHSEDAIEGPLAFAEKRDPVWKGR
>NZ_CP041996.1|WP_000122898.1|4062599_4063190_+|carnitine-operon-protein-CaiE
MSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLLVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFRGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEGNRPRLQGTTDVAPKR
>NZ_CP041996.1|WP_000333125.1|4063308_4063704_-|carnitine-metabolism-transcriptional-regulator-CaiF
MCEGYVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTEISCEVKMIPNKLEGRGCQCQRLVKVVDIDEQIYARLRNNSREKLVGVRKTPRIPAVPLTELNREQKWQMMLSKSMRR
>NZ_CP041996.1|WP_001126358.1|4063964_4067186_-|carbamoyl-phosphate-synthase-large-subunit
MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALRGLEVGATGFDPKVSLDDPEALTKIRRELKDAGAERIWYIADAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVGITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQYDLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDREKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQHAVERLKLKQPANATVTTIEMAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQTAVSVSNDAPVLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGVPLAKVAARVMAGKTLAEQGVTKEVIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALNADATEKVISVQEMHAQIK
>NZ_CP041996.1|WP_001361349.1|4067203_4068352_-|glutamine-hydrolyzing-carbamoyl-phosphate-synthase-small-subunit
MIKSALLVLEDGTQFHGRAIGATGSAVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNVGTNDADEESSQVHAQGLVIRDLPLIASNFRNTEDLSSYLKRHNIVAIADIDTRKLTRLLREKGAQNGCIIAGDNPDAALALEKARAFPGLNGMDLAKEVTTAETYSWTQGSWTLTGGLPEAKKEDELPFHVVAYDFGAKRNILRMLVDRGCRLTIVPAQTSAEDVLKMNPDGIFLSNGPGDPAPCDYAITAIQKFLETDIPVFGICLGHQLLALASGAKTIKMKFGHHGGNHPVKDVEKNVVMITAQNHGFAVDEATLPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDAAPLFDHFIALIEQYRKTAK
>NZ_CP041996.1|WP_000543585.1|4068807_4069629_-|4-hydroxy-tetrahydrodipicolinate-reductase
MHDANIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLDAIKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTGFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWLSGKESGLFDMRDVLDLNNL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP041996_1	1.2\|3543220\|25\|NZ_CP041996\|PILER-CR	3543220-3543244	25	NC_049946	Escherichia virus Lambda_4A7 genome assembly, chromosome: 1	37604-37628	0	1.0
NZ_CP041996_1	1.2\|3543220\|25\|NZ_CP041996\|PILER-CR	3543220-3543244	25	LR595861	Escherichia virus Lambda_4C10 genome assembly, chromosome: 1	37887-37911	0	1.0
NZ_CP041996_1	1.1\|3543173\|24\|NZ_CP041996\|PILER-CR	3543173-3543196	24	NC_049946	Escherichia virus Lambda_4A7 genome assembly, chromosome: 1	37652-37675	1	0.958
NZ_CP041996_1	1.1\|3543173\|24\|NZ_CP041996\|PILER-CR	3543173-3543196	24	LR595861	Escherichia virus Lambda_4C10 genome assembly, chromosome: 1	37935-37958	1	0.958
NZ_CP041996_1	1.2\|3543220\|25\|NZ_CP041996\|PILER-CR	3543220-3543244	25	NZ_AP023208	Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence	44524-44548	1	0.96
NZ_CP041996_2	2.1\|4055675\|42\|NZ_CP041996\|PILER-CR	4055675-4055716	42	NZ_AP023206	Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence	141085-141126	1	0.976
NZ_CP041996_1	1.1\|3543173\|24\|NZ_CP041996\|PILER-CR	3543173-3543196	24	NZ_AP023208	Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence	44572-44595	2	0.917
NZ_CP041996_2	2.2\|4055734\|40\|NZ_CP041996\|PILER-CR	4055734-4055773	40	NZ_AP023206	Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence	141028-141067	2	0.95
NZ_CP041996_1	1.1\|3543173\|24\|NZ_CP041996\|PILER-CR	3543173-3543196	24	NC_049946	Escherichia virus Lambda_4A7 genome assembly, chromosome: 1	37675-37698	3	0.875
NZ_CP041996_1	1.1\|3543173\|24\|NZ_CP041996\|PILER-CR	3543173-3543196	24	LR595861	Escherichia virus Lambda_4C10 genome assembly, chromosome: 1	37958-37981	3	0.875
NZ_CP041996_1	1.1\|3543173\|24\|NZ_CP041996\|PILER-CR	3543173-3543196	24	MT661596	Proteus phage 10, complete genome	116931-116954	3	0.875
NZ_CP041996_1	1.2\|3543220\|25\|NZ_CP041996\|PILER-CR	3543220-3543244	25	NZ_CP015341	Lactobacillus brevis strain 100D8 plasmid unnamed3, complete sequence	35661-35685	4	0.84

1. spacer 1.2|3543220|25|NZ_CP041996|PILER-CR matches to NC_049946 (Escherichia virus Lambda_4A7 genome assembly, chromosome: 1) position: , mismatch: 0, identity: 1.0

tttacctctttcaggtaaactttat	CRISPR spacer
tttacctctttcaggtaaactttat	Protospacer
*************************

2. spacer 1.2|3543220|25|NZ_CP041996|PILER-CR matches to LR595861 (Escherichia virus Lambda_4C10 genome assembly, chromosome: 1) position: , mismatch: 0, identity: 1.0

tttacctctttcaggtaaactttat	CRISPR spacer
tttacctctttcaggtaaactttat	Protospacer
*************************

3. spacer 1.1|3543173|24|NZ_CP041996|PILER-CR matches to NC_049946 (Escherichia virus Lambda_4A7 genome assembly, chromosome: 1) position: , mismatch: 1, identity: 0.958

cgtctttacctgatttgggtaaac	CRISPR spacer
cgcctttacctgatttgggtaaac	Protospacer
**.*********************

4. spacer 1.1|3543173|24|NZ_CP041996|PILER-CR matches to LR595861 (Escherichia virus Lambda_4C10 genome assembly, chromosome: 1) position: , mismatch: 1, identity: 0.958

cgtctttacctgatttgggtaaac	CRISPR spacer
cgcctttacctgatttgggtaaac	Protospacer
**.*********************

5. spacer 1.2|3543220|25|NZ_CP041996|PILER-CR matches to NZ_AP023208 (Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence) position: , mismatch: 1, identity: 0.96

tttacctctttcaggtaaactttat	CRISPR spacer
tttacctctttaaggtaaactttat	Protospacer
*********** *************

6. spacer 2.1|4055675|42|NZ_CP041996|PILER-CR matches to NZ_AP023206 (Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence) position: , mismatch: 1, identity: 0.976

tgtcacacgcagataaatccaactttcaatattgttaagctc	CRISPR spacer
tgtcacacgcagataaatccaactttcaatattgttaagttc	Protospacer
***************************************.**

7. spacer 1.1|3543173|24|NZ_CP041996|PILER-CR matches to NZ_AP023208 (Escherichia coli strain TUM18781 plasmid pMTY18781-3, complete sequence) position: , mismatch: 2, identity: 0.917

cgtctttacctgatttgggtaaac	CRISPR spacer
tgcctttacctgatttgggtaaac	Protospacer
.*.*********************

8. spacer 2.2|4055734|40|NZ_CP041996|PILER-CR matches to NZ_AP023206 (Escherichia coli strain TUM18781 plasmid pMTY18781-1_lncX3, complete sequence) position: , mismatch: 2, identity: 0.95

catggcgtagcaaaaagaaattttcaatattgttttatgg	CRISPR spacer
catggcgtagaaaaaagaaattttcaatattgctttatgg	Protospacer
********** *********************.*******

9. spacer 1.1|3543173|24|NZ_CP041996|PILER-CR matches to NC_049946 (Escherichia virus Lambda_4A7 genome assembly, chromosome: 1) position: , mismatch: 3, identity: 0.875

cgtctttacctgatttgggtaaac	CRISPR spacer
tgtgtttacctgattcgggtaaac	Protospacer
.** ***********.********

10. spacer 1.1|3543173|24|NZ_CP041996|PILER-CR matches to LR595861 (Escherichia virus Lambda_4C10 genome assembly, chromosome: 1) position: , mismatch: 3, identity: 0.875

cgtctttacctgatttgggtaaac	CRISPR spacer
tgtgtttacctgattcgggtaaac	Protospacer
.** ***********.********

11. spacer 1.1|3543173|24|NZ_CP041996|PILER-CR matches to MT661596 (Proteus phage 10, complete genome) position: , mismatch: 3, identity: 0.875

cgtctttacctgatttgggtaaac	CRISPR spacer
tgtctgtacctgaattgggtaaac	Protospacer
.**** ******* **********

12. spacer 1.2|3543220|25|NZ_CP041996|PILER-CR matches to NZ_CP015341 (Lactobacillus brevis strain 100D8 plasmid unnamed3, complete sequence) position: , mismatch: 4, identity: 0.84

tttacctctttcaggtaaactttat	CRISPR spacer
ggtatctcattcaggtaaactttat	Protospacer
  **.*** ****************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

98903 : 103557

Stx2-converting_phage(50.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000624622.1\|98903_99251_-	IS66 family insertion sequence element accessory protein TnpB	A0A0P0ZDM8	Stx2-converting_phage	2.6e-46	76.6
WP_001339397.1\|99250_99928_-	IS66 family insertion sequence hypothetical protein	A0A0P0ZCV4	Stx2-converting_phage	3.3e-21	46.0
WP_089075440.1\|99904_100012_+	copper resistance protein	NA	NA	NA	NA
WP_096427327.1\|99977_100181_-\|transposase	transposase	B6DZU5	Stx2-converting_phage	2.5e-33	100.0
WP_061092934.1\|100837_102100_+	four-carbon acid sugar kinase family protein	A0A077SLJ7	Escherichia_phage	6.0e-93	45.8
WP_061092935.1\|102096_102735_+	aldolase	A0A077SK32	Escherichia_phage	6.6e-56	52.7
WP_061092936.1\|102750_103557_+	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	4.2e-47	42.1

DBSCAN-SWA_2

1109704 : 1199913

102

Burkholderia_virus(37.5%)

tail,plate,tRNA,head,transposase,integrase

attL 1112359:1112374|attR 1161188:1161203

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000889991.1\|1109704_1110487_+\|tRNA	tRNA pseudouridine(65) synthase TruC	NA	NA	NA	NA
WP_000807747.1\|1110504_1110954_+	flavodoxin	NA	NA	NA	NA
WP_000097082.1\|1111388_1112741_+	MFS transporter	NA	NA	NA	NA
1112359:1112374	attL	NA	NA	NA	NA
WP_000211776.1\|1112742_1114083_+	glucarate dehydratase	Q6A202	Oenococcus_phage	9.1e-07	24.3
WP_110826424.1\|1114103_1115369_+	glucarate dehydratase	NA	NA	NA	NA
WP_001571573.1\|1115717_1116350_-	hypothetical protein	NA	NA	NA	NA
WP_001281696.1\|1116464_1116863_-	DNA-binding protein	Q6QIE8	Burkholderia_phage	3.9e-30	55.9
WP_000988473.1\|1116834_1117287_-	regulatory protein GemA	A4JWM5	Burkholderia_virus	1.6e-24	46.6
WP_000123379.1\|1117276_1117492_-	hypothetical protein	NA	NA	NA	NA
WP_000631814.1\|1117481_1117712_-	hypothetical protein	NA	NA	NA	NA
WP_000131939.1\|1117708_1118392_-	DUF2786 domain-containing protein	A0A2P9JZH4	Alteromonadaceae_phage	4.5e-34	36.9
WP_000197789.1\|1118388_1118694_-	hypothetical protein	NA	NA	NA	NA
WP_042203510.1\|1118703_1118976_-	hypothetical protein	NA	NA	NA	NA
WP_050559426.1\|1119032_1119254_+	hypothetical protein	NA	NA	NA	NA
WP_001381528.1\|1119264_1119795_-	bacteriophage Mu Gam like family protein	L7P7T1	Pseudomonas_phage	1.2e-58	66.7
WP_000843446.1\|1119822_1120092_-	hypothetical protein	NA	NA	NA	NA
WP_000960680.1\|1120094_1121261_-	AAA family ATPase	A4JWN1	Burkholderia_virus	9.7e-122	59.7
WP_110826423.1\|1121271_1123041_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A4JWN2	Burkholderia_virus	3.1e-228	69.6
WP_061092904.1\|1123056_1123374_-	hypothetical protein	NA	NA	NA	NA
WP_106631226.1\|1123373_1124291_-	DUF3102 domain-containing protein	A4JWN3	Burkholderia_virus	2.4e-75	55.0
WP_029490537.1\|1124301_1124610_-	helix-turn-helix domain-containing protein	Q5ZR02	Pseudomonas_phage	3.5e-23	55.9
WP_021518100.1\|1124663_1124852_-	DNA-binding protein	Q5ZQZ9	Pseudomonas_phage	1.8e-17	71.0
WP_029490538.1\|1124940_1125306_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_110826422.1\|1125424_1126189_-	DNA adenine methylase	A2I2Y7	Vibrio_virus	4.0e-100	64.4
WP_001069609.1\|1126380_1126596_-	hypothetical protein	NA	NA	NA	NA
WP_000972292.1\|1126594_1126999_+	hypothetical protein	NA	NA	NA	NA
WP_000194949.1\|1126974_1127718_-	hypothetical protein	NA	NA	NA	NA
WP_000793145.1\|1127848_1128199_+	membrane protein	A4JWP3	Burkholderia_virus	9.0e-23	53.9
WP_001104438.1\|1128201_1128939_+	transglycosylase SLT domain-containing protein	Q5ZQZ1	Pseudomonas_phage	2.9e-63	59.5
WP_001299256.1\|1128967_1129579_+	hypothetical protein	A0A0S4L1H0	Pseudomonas_phage	6.9e-10	34.2
WP_000175097.1\|1129575_1129902_+	membrane protein	Q6QIC4	Burkholderia_phage	9.6e-19	49.5
WP_000227704.1\|1129901_1130213_+	hypothetical protein	A0A0S4L0A3	Pseudomonas_phage	4.0e-30	60.6
WP_000533684.1\|1130215_1130758_+	DUF3486 family protein	A4JWJ3	Burkholderia_virus	4.9e-44	53.3
WP_000137893.1\|1130754_1132278_+	hypothetical protein	A4JWJ4	Burkholderia_virus	1.8e-184	62.5
WP_021512536.1\|1132277_1133774_+	DUF935 domain-containing protein	A4JWJ5	Burkholderia_virus	6.1e-169	59.6
WP_000117556.1\|1133754_1134576_+\|head	phage head morphogenesis protein	A4JWJ6	Burkholderia_virus	3.1e-98	61.5
WP_000135514.1\|1134578_1135037_+	phage virion morphogenesis protein	Q6QIB8	Burkholderia_phage	2.6e-30	44.8
WP_001273074.1\|1135251_1136367_+	hypothetical protein	A4JWJ9	Burkholderia_virus	9.4e-98	51.6
WP_001286908.1\|1136381_1137335_+	hypothetical protein	A4JWK0	Burkholderia_virus	3.4e-64	43.8
WP_000537457.1\|1137344_1137683_+	DUF2190 family protein	NA	NA	NA	NA
WP_000271668.1\|1137684_1138131_+	DUF1320 domain-containing protein	A4JWK2	Burkholderia_virus	2.2e-34	52.3
WP_021539012.1\|1138130_1138595_+	hypothetical protein	Q6QIB2	Burkholderia_phage	1.3e-37	51.0
WP_012602372.1\|1138591_1138846_+	hypothetical protein	NA	NA	NA	NA
WP_000729834.1\|1138835_1140263_+\|tail	tail protein	A4JWK5	Burkholderia_virus	4.5e-214	76.3
WP_000034294.1\|1140262_1140784_+\|tail	phage major tail tube protein	A4JWK6	Burkholderia_virus	1.8e-67	67.6
WP_000110114.1\|1140786_1141068_+	hypothetical protein	NA	NA	NA	NA
WP_000084213.1\|1141165_1141501_+\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_001202894.1\|1141424_1141583_+\|tail	GpE family phage tail protein	NA	NA	NA	NA
WP_001529030.1\|1141658_1144871_+\|tail	phage tail tape measure protein	A4JWL0	Burkholderia_virus	5.8e-84	31.3
WP_000458387.1\|1144870_1145755_+\|tail	phage tail protein	A4JWL1	Burkholderia_virus	6.8e-51	47.9
WP_012602373.1\|1145751_1145967_+	membrane protein	Q6QIA3	Burkholderia_phage	1.2e-17	57.1
WP_001529032.1\|1145954_1147127_+	phage late control D family protein	Q6QIA2	Burkholderia_phage	7.3e-85	47.1
WP_000148265.1\|1147123_1147720_+\|plate	phage baseplate assembly protein V	A4JWL4	Burkholderia_virus	5.4e-36	45.2
WP_000859116.1\|1147774_1148122_+\|plate	baseplate protein	Q6QIA0	Burkholderia_phage	1.7e-34	61.5
WP_001529034.1\|1148112_1149216_+	hypothetical protein	Q6QI99	Burkholderia_phage	1.4e-106	55.0
WP_000138756.1\|1149208_1149787_+\|tail	phage tail protein I	A4JWL7	Burkholderia_virus	1.7e-66	66.8
WP_096976434.1\|1149789_1151721_+	short-chain fatty acid transporter	A0A0K2FIZ6	Escherichia_phage	9.0e-40	44.4
WP_001529037.1\|1151720_1152335_+\|tail	tail assembly chaperone	Q9MCR5	Enterobacteria_phage	1.7e-61	61.5
WP_001529038.1\|1152341_1152815_-\|tail	tail fiber protein	A0A0F7LCR3	Escherichia_phage	8.1e-35	52.4
WP_000904922.1\|1152886_1153459_+	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	4.6e-85	85.2
WP_000186450.1\|1153861_1156618_-	two-component sensor histidine kinase BarA	A0A1V0SGX0	Hokovirus	6.4e-55	30.6
WP_000046818.1\|1156674_1157976_+	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	A0A2K5B251	Erysipelothrix_phage	2.6e-38	29.8
WP_000226815.1\|1158023_1160258_+	GTP pyrophosphokinase	NA	NA	NA	NA
WP_000581940.1\|1160335_1160584_+	type II toxin-antitoxin system antitoxin MazE	NA	NA	NA	NA
WP_000254738.1\|1160583_1160919_+	endoribonuclease MazF	NA	NA	NA	NA
WP_001071641.1\|1160990_1161782_+	nucleoside triphosphate pyrophosphohydrolase	NA	NA	NA	NA
1161188:1161203	attR	NA	NA	NA	NA
WP_000210878.1\|1162009_1163647_+	CTP synthase (glutamine hydrolyzing)	A0A1J0FA14	Only_Syngen_Nebraska_virus	1.8e-153	50.4
WP_000036723.1\|1163733_1165032_+	phosphopyruvate hydratase	A0A1X9I5Z8	Streptococcus_phage	2.0e-131	58.8
WP_089075444.1\|1165091_1165964_-	YgcG family protein	NA	NA	NA	NA
WP_001217974.1\|1165969_1167118_-	YgcG family protein	NA	NA	NA	NA
WP_001243483.1\|1167132_1168026_-	YgcG family protein	NA	NA	NA	NA
WP_000944228.1\|1168039_1168642_-	LemA family protein	NA	NA	NA	NA
WP_001199974.1\|1168814_1169486_+	7-carboxy-7-deazaguanine synthase QueE	A0A2I7S8X1	Vibrio_phage	3.0e-14	25.0
WP_001232705.1\|1169570_1170578_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_032245922.1\|1170603_1172013_-	sucrose-6-phosphate hydrolase	F8WPR5	Bacillus_phage	5.6e-15	22.7
WP_061092716.1\|1172012_1173383_-	PTS sucrose transporter subunit IIBC	NA	NA	NA	NA
WP_000277206.1\|1173443_1174961_-	carbohydrate porin	NA	NA	NA	NA
WP_001276284.1\|1175131_1176049_-	aminoimidazole riboside kinase	NA	NA	NA	NA
WP_000039729.1\|1176213_1177692_-	sugar kinase	NA	NA	NA	NA
WP_001164562.1\|1177718_1178996_-	MFS transporter	NA	NA	NA	NA
WP_001361315.1\|1179313_1180099_+	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	1.1e-20	32.1
WP_000059294.1\|1180168_1181623_+	FAD-binding oxidoreductase	NA	NA	NA	NA
WP_024179464.1\|1181716_1183054_+	MFS transporter	NA	NA	NA	NA
WP_001361314.1\|1183031_1183811_+	electron transfer flavoprotein subunit beta/FixA family protein	NA	NA	NA	NA
WP_001361313.1\|1183807_1184668_+	electron transfer flavoprotein subunit alpha/FixB family protein	NA	NA	NA	NA
WP_001130256.1\|1184814_1185390_-	glycerol-3-phosphate responsive antiterminator	NA	NA	NA	NA
WP_000109536.1\|1185406_1185667_-	ferredoxin family protein	NA	NA	NA	NA
WP_001361312.1\|1185657_1186929_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_000987944.1\|1187006_1187372_-	6-carboxytetrahydropterin synthase QueD	NA	NA	NA	NA
WP_000211339.1\|1187687_1189487_+	NADPH-dependent assimilatory sulfite reductase flavoprotein subunit	NA	NA	NA	NA
WP_001290706.1\|1189486_1191199_+	assimilatory sulfite reductase (NADPH) hemoprotein subunit	NA	NA	NA	NA
WP_000039852.1\|1191272_1192007_+	phosphoadenosine phosphosulfate reductase	NA	NA	NA	NA
WP_000956458.1\|1192271_1192424_+	type I toxin-antitoxin system Hok family toxin	NA	NA	NA	NA
WP_000490426.1\|1192549_1193587_-	alkaline phosphatase isozyme conversion aminopeptidase	NA	NA	NA	NA
WP_000372392.1\|1193838_1194747_+	sulfate adenylyltransferase subunit CysD	NA	NA	NA	NA
WP_001090363.1\|1194748_1196176_+	sulfate adenylyltransferase subunit CysN	A0A1V0SGC3	Hokovirus	9.7e-31	31.4
WP_001173673.1\|1196175_1196781_+	adenylyl-sulfate kinase	A0A2K9L4R9	Tupanvirus	4.2e-28	38.1
WP_001246103.1\|1196830_1197154_+	DUF3561 family protein	NA	NA	NA	NA
WP_000517476.1\|1197347_1197659_+	cell division protein FtsB	NA	NA	NA	NA
WP_000246153.1\|1197677_1198388_+	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	NA	NA	NA	NA
WP_001219237.1\|1198387_1198867_+	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	NA	NA	NA	NA
WP_000568908.1\|1198863_1199913_+\|tRNA	tRNA pseudouridine(13) synthase TruD	NA	NA	NA	NA

DBSCAN-SWA_3

1576789 : 1589717

Escherichia_phage(83.33%)

integrase

attL 1571750:1571763|attR 1578889:1578902

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1571750:1571763	attL	NA	NA	NA	NA
WP_001224627.1\|1576789_1577359_-\|integrase	tyrosine-type recombinase/integrase	A0A2L1IV36	Escherichia_phage	9.1e-49	52.2
WP_001181154.1\|1578107_1578737_+\|integrase	tyrosine-type recombinase/integrase	A0A2L1IV36	Escherichia_phage	5.4e-119	99.0
WP_000243052.1\|1579054_1579675_+	LuxR family transcriptional regulator	A0A2L1IV08	Escherichia_phage	1.3e-117	99.0
1578889:1578902	attR	NA	NA	NA	NA
WP_001361862.1\|1579699_1587619_+	autotransporter outer membrane beta-barrel domain-containing protein	A0A2L1IV38	Escherichia_phage	0.0e+00	97.9
WP_000100042.1\|1587666_1588197_+	hypothetical protein	A0A2L1IV11	Escherichia_phage	3.3e-85	97.7
WP_000368135.1\|1588784_1589717_-	formate/nitrite transporter family protein	E7DYY8	Enterobacteria_phage	2.1e-167	99.7

DBSCAN-SWA_4

2886921 : 2932324

Ralstonia_phage(20.0%)

transposase,integrase,plate

attL 2900847:2900861|attR 2911382:2911396

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_061093005.1\|2886921_2888142_+\|integrase	site-specific integrase	A0A077KET4	Ralstonia_phage	6.2e-79	41.3
WP_061093006.1\|2888343_2888733_+	glyoxalase	NA	NA	NA	NA
WP_061093007.1\|2888875_2890339_-	shufflon system plasmid conjugative transfer pilus tip adhesin PilV	NA	NA	NA	NA
WP_000243502.1\|2890391_2890949_-	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_061093008.1\|2891344_2891650_-	conjugal transfer protein TraD	NA	NA	NA	NA
WP_061093009.1\|2891646_2892012_-	hypothetical protein	NA	NA	NA	NA
WP_001608346.1\|2892316_2893195_+	hypothetical protein	NA	NA	NA	NA
WP_001608347.1\|2893198_2893507_-	hypothetical protein	NA	NA	NA	NA
WP_061093010.1\|2894156_2895638_+	MobA/MobL family protein	NA	NA	NA	NA
WP_001142313.1\|2895716_2896199_+	hypothetical protein	NA	NA	NA	NA
WP_000177655.1\|2896257_2896830_+	hypothetical protein	NA	NA	NA	NA
WP_021513669.1\|2896923_2897454_-	lipoprotein	NA	NA	NA	NA
WP_061093011.1\|2897888_2898362_+	DUF4755 domain-containing protein	NA	NA	NA	NA
WP_001519851.1\|2898393_2898771_+	hypothetical protein	NA	NA	NA	NA
WP_001519852.1\|2898820_2899432_-	TIR domain-containing protein	NA	NA	NA	NA
WP_001519853.1\|2899448_2900885_-	hypothetical protein	NA	NA	NA	NA
2900847:2900861	attL	NA	NA	NA	NA
WP_021513673.1\|2902188_2902575_-	hypothetical protein	NA	NA	NA	NA
WP_021513674.1\|2902702_2902927_-	hypothetical protein	NA	NA	NA	NA
WP_001519857.1\|2903841_2904387_+	hypothetical protein	NA	NA	NA	NA
WP_061093067.1\|2904541_2905021_+	DUF4756 family protein	NA	NA	NA	NA
WP_061093068.1\|2905178_2905583_+	H-NS histone family protein	NA	NA	NA	NA
WP_000505227.1\|2905646_2905997_-	hypothetical protein	NA	NA	NA	NA
WP_001519860.1\|2906101_2906344_-	hypothetical protein	NA	NA	NA	NA
WP_032283297.1\|2906417_2906714_-	hypothetical protein	NA	NA	NA	NA
WP_059256365.1\|2906758_2907049_-	hypothetical protein	NA	NA	NA	NA
WP_021580845.1\|2907130_2907349_-	AlpA family transcriptional regulator	A0A2H4J8C8	uncultured_Caudovirales_phage	1.2e-09	51.9
WP_021524272.1\|2907564_2908401_-	hypothetical protein	NA	NA	NA	NA
WP_001302302.1\|2908862_2909660_+	DgsA anti-repressor MtfA	NA	NA	NA	NA
WP_072652861.1\|2910002_2911265_+\|integrase	integrase arm-type DNA-binding domain-containing protein	Q7M297	Enterobacteria_phage	3.8e-71	37.3
WP_096427310.1\|2911565_2912779_-\|transposase	IS3 family transposase	Q716C2	Shigella_phage	1.1e-102	58.1
2911382:2911396	attR	NA	NA	NA	NA
WP_061093050.1\|2912799_2913528_-	hypothetical protein	NA	NA	NA	NA
WP_061093049.1\|2913807_2914599_+	hypothetical protein	NA	NA	NA	NA
WP_061093048.1\|2914807_2915107_-	hypothetical protein	NA	NA	NA	NA
WP_061093047.1\|2915159_2915639_-	Hcp family type VI secretion system effector	NA	NA	NA	NA
WP_061093046.1\|2915660_2917016_-	hypothetical protein	NA	NA	NA	NA
WP_123056338.1\|2917026_2920458_-	type VI secretion system membrane subunit TssM	NA	NA	NA	NA
WP_061093044.1\|2920566_2921994_-	type VI secretion system protein TssA	NA	NA	NA	NA
WP_061093043.1\|2921998_2922742_-	type VI secretion system-associated protein TagO	NA	NA	NA	NA
WP_061093042.1\|2922738_2925477_-	type VI secretion system ATPase TssH	K4FB40	Cronobacter_phage	2.9e-84	31.1
WP_123056339.1\|2925488_2926229_-	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_061093041.1\|2926311_2927655_-\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_061093040.1\|2927657_2928191_-	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_061093052.1\|2928187_2929474_-	type VI secretion system-associated FHA domain protein TagH	NA	NA	NA	NA
WP_061093053.1\|2929490_2930534_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_061093039.1\|2930500_2932324_-\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA

DBSCAN-SWA_5

2958069 : 2968727

uncultured_Caudovirales_phage(33.33%)

transposase,integrase

attL 2957826:2957885|attR 2975138:2975219

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2957826:2957885	attL	NA	NA	NA	NA
WP_072693178.1\|2958069_2959332_+\|integrase	integrase arm-type DNA-binding domain-containing protein	B7SYF8	Stenotrophomonas_phage	2.5e-70	38.8
WP_021550960.1\|2959455_2959773_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A141GEX6	Brucella_phage	9.3e-11	41.9
WP_016248851.1\|2959776_2960085_+	putative addiction module antidote protein	NA	NA	NA	NA
WP_052895708.1\|2960207_2960501_-	hypothetical protein	NA	NA	NA	NA
WP_077249107.1\|2960503_2961217_-	RHS repeat-associated core domain-containing protein	A0A2H4JFP5	uncultured_Caudovirales_phage	8.2e-23	35.5
WP_061093069.1\|2961261_2961603_-	hypothetical protein	NA	NA	NA	NA
WP_148906086.1\|2961613_2965702_-	RHS repeat protein	A0A2H4JFP5	uncultured_Caudovirales_phage	1.5e-23	35.6
WP_085949836.1\|2965849_2967062_+\|transposase	IS3 family transposase	Q716C2	Shigella_phage	4.7e-103	58.4
WP_061092891.1\|2967066_2967402_-	DUF2169 domain-containing protein	NA	NA	NA	NA
WP_077249124.1\|2967840_2968476_+	hypothetical protein	NA	NA	NA	NA
WP_061092889.1\|2968472_2968727_+	transcriptional regulator	A0A2I7S995	Vibrio_phage	1.7e-15	61.2
2975138:2975219	attR	NA	NA	NA	NA

DBSCAN-SWA_6

3015859 : 3027117

Acanthocystis_turfacea_Chlorella_virus(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000704860.1\|3015859_3017026_-	UDP-glucose 6-dehydrogenase	M1I798	Paramecium_bursaria_Chlorella_virus	1.7e-110	52.2
WP_000043484.1\|3017273_3018680_-	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	1.4e-37	28.3
WP_000736848.1\|3018843_3020214_-	phosphomannomutase CpsG	A0A127AWJ1	Bacillus_phage	6.4e-32	28.4
WP_000868618.1\|3020238_3020985_-	glycosyltransferase	A0A1V0SAH6	Catovirus	2.1e-08	41.6
WP_001361571.1\|3021068_3022454_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	1.9e-47	29.5
WP_001042472.1\|3022465_3022921_-	GDP-mannose mannosyl hydrolase	NA	NA	NA	NA
WP_000163129.1\|3022923_3023889_-	GDP-L-fucose synthase	M1I5W5	Acanthocystis_turfacea_Chlorella_virus	9.9e-88	51.7
WP_000335121.1\|3023892_3025014_-	GDP-mannose 4,6-dehydratase	M1HVG7	Acanthocystis_turfacea_Chlorella_virus	2.2e-131	64.7
WP_000699784.1\|3025024_3026032_-	glycosyltransferase family 4 protein	NA	NA	NA	NA
WP_000026026.1\|3026100_3027117_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	6.3e-77	44.3

DBSCAN-SWA_7

3139257 : 3148699

Enterobacteria_phage(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001292746.1\|3139257_3140394_+	VWA domain-containing protein	Q9EYF7	Enterobacteria_phage	5.9e-164	98.4
WP_001361589.1\|3140390_3142391_+	hypothetical protein	Q9EYF6	Enterobacteria_phage	0.0e+00	94.9
WP_001296231.1\|3142515_3142977_+	YehR family lipoprotein	Q9EYF5	Enterobacteria_phage	3.2e-76	99.3
WP_001361590.1\|3143017_3143488_-	DUF1456 family protein	Q9EYF4	Enterobacteria_phage	1.5e-81	99.4
WP_001308766.1\|3143534_3144254_-	two-component system response regulator BtsR	NA	NA	NA	NA
WP_001334139.1\|3144250_3145936_-	two-component regulatory system sensor histidine kinase BtsS	Q9EYF3	Enterobacteria_phage	9.5e-304	99.5
WP_001240398.1\|3146157_3146889_+	HTH-type transcriptional regulator MlrA	Q9EYF2	Enterobacteria_phage	2.8e-111	99.0
WP_001216963.1\|3146948_3147056_+	protein YohO	NA	NA	NA	NA
WP_000783133.1\|3147036_3147768_-	glycine betaine ABC transporter permease YehW	NA	NA	NA	NA
WP_000569365.1\|3147772_3148699_-	glycine betaine ABC transporter ATP binding protein YehX	G3M9Y6	Bacillus_virus	1.7e-23	30.8

DBSCAN-SWA_8

3503509 : 3551752

Enterobacteria_phage(50.0%)

tail,protease,lysis,terminase,head,capsid,integrase,holin,portal

attL 3503041:3503087|attR 3551766:3551812

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3503041:3503087	attL	NA	NA	NA	NA
WP_061092798.1\|3503509_3504463_+\|protease	omptin family outer membrane protease OmpT	NA	NA	NA	NA
WP_001226375.1\|3504649_3506134_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000239881.1\|3506672_3507341_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_001309429.1\|3507285_3507423_-	hypothetical protein	NA	NA	NA	NA
WP_016245272.1\|3507533_3507827_-	hypothetical protein	NA	NA	NA	NA
WP_000235975.1\|3507837_3508542_-	hypothetical protein	A0A1X7QGH6	Escherichia_phage	5.4e-59	62.3
WP_061092797.1\|3508551_3508833_-	hypothetical protein	A0A1X7QHA1	Escherichia_phage	2.7e-17	47.8
WP_061092796.1\|3508832_3511205_-\|tail	phage tail protein	A0A1X7QGG5	Escherichia_phage	7.9e-163	68.8
WP_001228252.1\|3511269_3511869_-	Ail/Lom family outer membrane beta-barrel protein	Q9EV15	Enterobacteria_phage	3.4e-102	92.5
WP_061092795.1\|3511936_3515416_-	host specificity protein J	A0A291AWT4	Escherichia_phage	0.0e+00	90.2
WP_000090882.1\|3515476_3516079_-\|tail	tail assembly protein	A5LH42	Enterobacteria_phage	6.2e-88	85.1
WP_024177847.1\|3516015_3516759_-\|tail	phage tail protein	K7PLW1	Enterobacteria_phage	1.8e-145	96.0
WP_001518412.1\|3516763_3517462_-\|tail	phage minor tail protein L	A0A0K2FJ01	Enterobacteria_phage	9.9e-130	97.4
WP_000847401.1\|3517461_3517791_-\|tail	phage tail protein	A0A2R9YJM0	Escherichia_phage	6.0e-53	92.7
WP_001567091.1\|3517787_3520349_-\|tail	phage tail tape measure protein	A0A0K2FI43	Enterobacteria_phage	0.0e+00	99.2
WP_001518410.1\|3520341_3520731_-\|tail	phage tail assembly protein T	A0A0K2FJB3	Enterobacteria_phage	3.4e-55	98.1
WP_001518409.1\|3520757_3521180_-\|tail	phage minor tail protein G	A0A0K2FIQ8	Enterobacteria_phage	7.7e-69	95.0
WP_001518408.1\|3521195_3521936_-\|tail	phage tail protein	A0A0K2FJ05	Enterobacteria_phage	2.4e-126	95.5
WP_000683145.1\|3521943_3522339_-\|tail	tail protein	A0A2R9YJI2	Escherichia_phage	1.3e-70	100.0
WP_001518407.1\|3522335_3522914_-\|tail	phage tail protein	A0A2R9YJK4	Escherichia_phage	1.3e-79	99.0
WP_000752994.1\|3522925_3523279_-\|tail	tail attachment protein	A0A2R9YJJ5	Escherichia_phage	9.0e-63	100.0
WP_001518405.1\|3523290_3523689_-	hypothetical protein	A0A0K2FIR1	Enterobacteria_phage	5.2e-51	84.1
WP_000063252.1\|3523730_3524756_-\|capsid	major capsid protein	C6ZCY2	Enterobacteria_phage	3.9e-191	99.1
WP_001299443.1\|3524811_3525144_-\|head	head decoration protein	A0A2R9YJN3	Escherichia_phage	1.7e-55	100.0
WP_001518402.1\|3525153_3526473_-	S49 family peptidase	A0A0K2FI53	Enterobacteria_phage	4.8e-234	98.6
WP_001518401.1\|3526453_3528055_-\|portal	phage portal protein	A0A0K2FJC0	Enterobacteria_phage	1.1e-309	99.1
WP_000198149.1\|3528051_3528258_-\|head,tail	Lambda prophage-derived head-to-tail joining protein W	A0A2R9YJL2	Escherichia_phage	5.8e-30	100.0
WP_001518400.1\|3528254_3530180_-\|terminase	phage terminase large subunit family protein	A0A0K2FJ14	Enterobacteria_phage	0.0e+00	99.7
WP_000453566.1\|3530154_3530700_-	DNA-packaging protein	A0A0K2FIG2	Enterobacteria_phage	4.0e-94	98.3
WP_001307652.1\|3531088_3531283_+	YlcI/YnfO family protein	A0A0K2FIR8	Escherichia_phage	9.7e-27	96.8
WP_000738423.1\|3531645_3531939_+	increased serum survival lipoprotein Iss	K7PL54	Enterobacteria_phage	2.0e-44	91.8
WP_001228695.1\|3532029_3532212_-\|lysis	prophage lysis lipoprotein RzoD	K7PHU6	Enterobacteria_phage	2.9e-17	98.3
WP_001518397.1\|3532428_3532905_-	glycoside hydrolase family protein	K7PKX1	Enterobacterial_phage	9.5e-84	96.1
WP_001120496.1\|3532908_3533235_-\|holin	phage holin, lambda family	U5P0K7	Shigella_phage	1.2e-56	99.1
WP_000355468.1\|3533526_3534702_+	hypothetical protein	NA	NA	NA	NA
WP_000150292.1\|3534704_3535919_+	hypothetical protein	NA	NA	NA	NA
WP_001205470.1\|3535898_3536255_-	antitermination protein	A0A0P0ZCW0	Stx2-converting_phage	2.3e-58	92.0
WP_032139865.1\|3536339_3536480_-	YlcG family protein	K7PHH3	Enterobacteria_phage	6.5e-09	69.8
WP_001099712.1\|3536476_3536839_-	crossover junction endodeoxyribonuclease RusA	K7PM48	Enterobacteria_phage	4.3e-60	96.5
WP_000774488.1\|3536835_3537126_-	DUF1364 domain-containing protein	K7PGZ6	Enterobacteria_phage	4.3e-47	94.8
WP_000224919.1\|3537118_3537289_-	NinE family protein	NA	NA	NA	NA
WP_001053033.1\|3537288_3537744_-	DNA base-flipping protein YbcN	I6PD71	Cronobacter_phage	3.7e-61	67.5
WP_001309322.1\|3537740_3537842_-	hypothetical protein	NA	NA	NA	NA
WP_000068668.1\|3537940_3538870_-	hypothetical protein	A0A1R3Y6Z6	Salmonella_virus	3.0e-57	40.0
WP_001567061.1\|3539074_3539392_-	hypothetical protein	NA	NA	NA	NA
WP_000709069.1\|3539503_3541030_-	recombinase family protein	Q3HQV4	Burkholderia_phage	6.1e-31	27.7
WP_032139864.1\|3541087_3541195_-	hypothetical protein	NA	NA	NA	NA
WP_001070442.1\|3541286_3541619_-	SMR family multidrug efflux protein EmrE	NA	NA	NA	NA
WP_000145912.1\|3541686_3541989_-	protein ren	A0A0N6WES4	Escherichia_phage	2.6e-42	94.6
WP_001566186.1\|3541985_3542687_-	replication protein P	A0A0P0ZD31	Stx2-converting_phage	7.9e-127	97.0
WP_061092802.1\|3542683_3543613_-	replication protein	A0A0K2FJ31	Enterobacteria_phage	4.7e-111	68.4
WP_061092794.1\|3543699_3544239_-	regulator	M9NZI6	Enterobacteria_phage	7.5e-61	65.6
WP_001067459.1\|3544320_3544551_-	helix-turn-helix domain-containing protein	A0A2H4FNF3	Salmonella_phage	8.5e-22	68.0
WP_064767403.1\|3544655_3545345_+	helix-turn-helix transcriptional regulator	Q76H56	Enterobacteria_phage	1.2e-92	75.4
WP_061092792.1\|3545425_3545695_+	hypothetical protein	A0A2H4FNC7	Salmonella_phage	4.8e-32	75.3
WP_061092791.1\|3545826_3546144_+	hypothetical protein	NA	NA	NA	NA
WP_061092790.1\|3546699_3546906_+	hypothetical protein	K7P6H3	Enterobacteria_phage	4.2e-28	85.3
WP_000995439.1\|3546981_3547278_+	host-nuclease inhibitor protein Gam	A0A1I9LJN1	Stx_converting_phage	1.6e-49	100.0
WP_052953584.1\|3547283_3548069_+	phage recombination protein Bet	A0A1I9LJN0	Stx_converting_phage	2.4e-148	99.6
WP_024228451.1\|3548065_3548746_+	YqaJ viral recombinase family protein	A0A0P0ZCD4	Stx2-converting_phage	3.5e-132	99.6
WP_045173744.1\|3548742_3548901_+	DUF1317 family protein	A0A1U8QQC1	Enterobacteria_phage	1.8e-23	98.1
WP_032255841.1\|3548897_3549455_+	phage N-6-adenine-methyltransferase	E5AGF8	Erwinia_phage	3.2e-62	62.9
WP_001386642.1\|3549465_3549747_+	cell division protein ZapA	A0A0P0ZE02	Stx2-converting_phage	5.5e-47	98.9
WP_000763385.1\|3549845_3550064_+	TraR/DksA family transcriptional regulator	M1FQT7	Enterobacteria_phage	7.5e-36	100.0
WP_000488407.1\|3550111_3550390_+	DUF4222 domain-containing protein	M1FPC8	Enterobacteria_phage	4.9e-48	97.8
WP_000446905.1\|3550361_3550733_+	helix-turn-helix domain-containing protein	M1FJ59	Enterobacteria_phage	2.1e-46	81.0
WP_061092788.1\|3550588_3551752_+\|integrase	site-specific integrase	A0A088CD23	Shigella_phage	3.7e-198	86.0
3551766:3551812	attR	NA	NA	NA	NA

DBSCAN-SWA_9

4547499 : 4592888

Burkholderia_phage(31.58%)

tRNA,tail,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012602639.1\|4547499_4548537_-\|tRNA	tRNA dihydrouridine(20/20a) synthase DusA	NA	NA	NA	NA
WP_022646425.1\|4548898_4549903_-	DUF2713 family protein	NA	NA	NA	NA
WP_061092769.1\|4550220_4550736_+	zinc uptake transcriptional repressor Zur	NA	NA	NA	NA
WP_001296638.1\|4550777_4550987_-	CsbD family protein	NA	NA	NA	NA
WP_001562441.1\|4551102_4552428_-	MATE family efflux transporter DinF	NA	NA	NA	NA
WP_000646078.1\|4552500_4553109_-	repressor LexA	Q9G0C2	Lactococcus_phage	1.0e-13	38.0
WP_000002907.1\|4553218_4553587_-	diacylglycerol kinase	NA	NA	NA	NA
WP_000017354.1\|4553757_4556181_+	glycerol-3-phosphate 1-O-acyltransferase PlsB	NA	NA	NA	NA
WP_000455227.1\|4556335_4557208_-	4-hydroxybenzoate octaprenyltransferase	NA	NA	NA	NA
WP_001308201.1\|4557220_4557718_-	chorismate lyase	NA	NA	NA	NA
WP_061092770.1\|4557940_4559521_-	SopA family protein	NA	NA	NA	NA
WP_001361468.1\|4559748_4560669_-	maltose operon protein MalM	NA	NA	NA	NA
WP_000973665.1\|4560911_4562252_-	maltoporin LamB	NA	NA	NA	NA
WP_000179165.1\|4562323_4563439_-	maltose/maltodextrin ABC transporter ATP-binding protein MalK	Q6GZ03	Mycoplasma_phage	4.3e-18	31.7
WP_000695387.1\|4563803_4564994_+	maltose/maltodextrin ABC transporter substrate-binding protein MalE	NA	NA	NA	NA
WP_001361466.1\|4565147_4566692_+	maltose ABC transporter permease MalF	NA	NA	NA	NA
WP_001252058.1\|4566706_4567597_+	maltose ABC transporter permease MalG	NA	NA	NA	NA
WP_000202902.1\|4567690_4568101_-	phosphate-starvation-inducible protein PsiE	NA	NA	NA	NA
WP_001328330.1\|4568315_4568594_+	hypothetical protein	NA	NA	NA	NA
WP_000745730.1\|4568640_4570737_-	YjbH domain-containing protein	NA	NA	NA	NA
WP_000595548.1\|4570736_4571474_-	capsule biosynthesis GfcC family protein	NA	NA	NA	NA
WP_001361463.1\|4571470_4572109_-	YjbF family lipoprotein	NA	NA	NA	NA
WP_000757333.1\|4572222_4572465_-	polysaccharide production threonine-rich protein	NA	NA	NA	NA
WP_000789981.1\|4572818_4574468_-	glucose-6-phosphate isomerase	NA	NA	NA	NA
WP_001290321.1\|4574992_4576342_+	lysine-sensitive aspartokinase 3	NA	NA	NA	NA
WP_000619864.1\|4576396_4576744_-	DNA-binding protein	Q6QIE8	Burkholderia_phage	2.2e-21	49.0
WP_000758131.1\|4577281_4577569_+	membrane protein	Q6QIC8	Burkholderia_phage	1.5e-15	48.1
WP_000266448.1\|4577571_4578177_+	transglycosylase SLT domain-containing protein	Q5ZQZ1	Pseudomonas_phage	3.3e-57	57.1
WP_000777272.1\|4578189_4578504_+	membrane protein	Q5ZQY8	Pseudomonas_phage	9.2e-19	43.2
WP_000404767.1\|4578648_4579104_+	hypothetical protein	NA	NA	NA	NA
WP_000875310.1\|4579100_4579298_+	hypothetical protein	NA	NA	NA	NA
WP_000729835.1\|4579287_4580712_+\|tail	phage tail sheath family protein	A4JWK5	Burkholderia_virus	3.2e-191	70.4
WP_000907502.1\|4580711_4581236_+\|tail	phage major tail tube protein	Q6QIA9	Burkholderia_phage	9.5e-69	69.0
WP_000658214.1\|4581286_4581604_+\|tail	phage tail assembly protein	NA	NA	NA	NA
WP_015674804.1\|4581563_4581692_+\|tail	GpE family phage tail protein	NA	NA	NA	NA
WP_000271436.1\|4584168_4585122_+	chemotaxis protein	A4JWL1	Burkholderia_virus	3.3e-35	50.8
WP_001269711.1\|4585121_4585331_+	membrane protein	A4JWL2	Burkholderia_virus	1.3e-16	60.3
WP_001361462.1\|4585318_4586359_+	phage late control D family protein	A4JWL3	Burkholderia_virus	4.4e-73	44.8
WP_000679401.1\|4586368_4587070_+\|plate	phage baseplate assembly protein V	A0A067ZIM2	Vibrio_phage	4.9e-12	36.3
WP_001093498.1\|4587168_4587528_+\|plate	baseplate protein	Q6QIA0	Burkholderia_phage	4.7e-35	64.2
WP_000951744.1\|4587518_4588634_+\|plate	baseplate protein	Q6QI99	Burkholderia_phage	6.9e-101	51.4
WP_000359520.1\|4588626_4589343_+\|tail	phage tail protein I	Q6QI98	Burkholderia_phage	1.8e-22	37.2
WP_000135569.1\|4589345_4590926_+\|tail	phage tail protein	A0A0M3ULH6	Salmonella_phage	1.3e-84	40.8
WP_061092771.1\|4590922_4591630_+	DUF4376 domain-containing protein	A0A0E3JQ06	Enterobacteria_phage	4.1e-14	42.4
WP_061092772.1\|4591626_4592082_+	hypothetical protein	F6MIM0	Haemophilus_phage	2.3e-26	42.7
WP_061092773.1\|4592096_4592888_-	nucleotidyltransferase domain-containing protein	A0A2D1GQQ2	Pseudomonas_phage	2.0e-46	45.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP041997

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

7170 : 45277

Salmonella_phage(30.77%)

transposase,integrase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000608644.1\|7170_8433_+\|transposase	IS1380-like element ISEc9 family transposase	A0A1B0VDR3	Salmonella_phage	1.3e-39	100.0
WP_015387340.1\|8688_9564_+	class A extended-spectrum beta-lactamase CTX-M-55	A0A1B0VBP7	Salmonella_phage	2.4e-125	82.1
WP_001393253.1\|9610_9943_-	cupin fold metalloprotein, WbuC family	NA	NA	NA	NA
WP_072794551.1\|9866_10091_-	hypothetical protein	NA	NA	NA	NA
WP_001089727.1\|10120_11200_-	permease	NA	NA	NA	NA
WP_001175594.1\|11304_11628_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_071819239.1\|11788_12271_+	hypothetical protein	A0A2H4J5V6	uncultured_Caudovirales_phage	2.9e-40	68.5
WP_001067855.1\|12161_12866_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_000844627.1\|14503_14746_+\|transposase	transposase	NA	NA	NA	NA
WP_000470728.1\|14777_15455_-	tetracycline resistance transcriptional repressor TetR(A)	NA	NA	NA	NA
WP_001351729.1\|17783_18176_-	cysteine hydrolase	NA	NA	NA	NA
WP_000844627.1\|19988_20231_+\|transposase	transposase	NA	NA	NA	NA
WP_000058717.1\|22247_23132_-	EamA family transporter	NA	NA	NA	NA
WP_001351729.1\|23269_23662_-	cysteine hydrolase	NA	NA	NA	NA
WP_000470728.1\|25746_26424_-	tetracycline resistance transcriptional repressor TetR(A)	NA	NA	NA	NA
WP_000058717.1\|27732_28617_-	EamA family transporter	NA	NA	NA	NA
WP_001351729.1\|28754_29147_-	cysteine hydrolase	NA	NA	NA	NA
WP_001067855.1\|30780_31485_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_015344971.1\|32029_32314_-	hypothetical protein	NA	NA	NA	NA
WP_000845048.1\|32282_33296_-\|integrase	class 1 integron integrase IntI1	A0A1P8DJJ6	Virus_Rctr41k	1.0e-71	45.5
WP_004201280.1\|33451_33925_+	trimethoprim-resistant dihydrofolate reductase DfrA14	G3MBI7	Bacillus_virus	8.4e-16	28.9
WP_001067855.1\|33994_34699_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_072794601.1\|35069_38036_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	0.0e+00	72.8
WP_000427619.1\|38114_39119_+\|transposase	IS110-like element IS5075 family transposase	NA	NA	NA	NA
WP_000954592.1\|39300_39477_-	DUF4102 domain-containing protein	T1S9J3	Salmonella_phage	1.0e-06	68.6
WP_001082320.1\|40680_41484_+	aminoglycoside O-phosphotransferase APH(3'')-Ib	NA	NA	NA	NA
WP_000480972.1\|41483_42320_+	aminoglycoside O-phosphotransferase APH(6)-Id	NA	NA	NA	NA
WP_000027057.1\|42550_43411_-	class A broad-spectrum beta-lactamase TEM-1	Q1MVP3	Enterobacteria_phage	4.6e-161	100.0
WP_001235713.1\|43593_44151_-	recombinase family protein	Q1MVP4	Enterobacteria_phage	7.0e-94	100.0
WP_012512979.1\|44296_44476_-	hypothetical protein	NA	NA	NA	NA
WP_001067855.1\|44572_45277_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0

DBSCAN-SWA_2

99547 : 145093

Escherichia_phage(23.08%)

transposase,integrase,protease

attL 94496:94509|attR 107013:107026

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
94496:94509	attL	NA	NA	NA	NA
WP_012478345.1\|99547_100522_+\|transposase	IS30-like element ISApl1 family transposase	W5R8L2	Staphylococcus_phage	2.3e-52	39.1
WP_049589868.1\|100717_102343_+	phosphoethanolamine--lipid A transferase MCR-1.1	NA	NA	NA	NA
WP_077248209.1\|102390_103137_+	PAP2 family protein	NA	NA	NA	NA
WP_001805195.1\|103162_103507_+	hypothetical protein	NA	NA	NA	NA
WP_000795947.1\|103528_104704_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_001285422.1\|104874_105087_+	hypothetical protein	NA	NA	NA	NA
WP_001232449.1\|105447_106530_+	hypothetical protein	NA	NA	NA	NA
WP_001284313.1\|106696_108196_-	kinase	NA	NA	NA	NA
107013:107026	attR	NA	NA	NA	NA
WP_000081622.1\|108221_109859_-	protein phosphatase 2C domain-containing protein	NA	NA	NA	NA
WP_001253653.1\|109858_110899_-	VWA domain-containing protein	NA	NA	NA	NA
WP_001253658.1\|110984_111623_-	VWA domain-containing protein	NA	NA	NA	NA
WP_000116681.1\|111622_112264_-	TerD family protein	NA	NA	NA	NA
WP_001388628.1\|112286_112925_-	VWA domain-containing protein	NA	NA	NA	NA
WP_001176767.1\|113387_113855_-	tellurium resistance protein TerW	NA	NA	NA	NA
WP_000506887.1\|113872_115081_-	DUF4236 domain-containing protein	NA	NA	NA	NA
WP_000797366.1\|115091_116048_-	HpcH/HpaI aldolase/citrate lyase family protein	NA	NA	NA	NA
WP_042634304.1\|116047_117127_-\|protease	cysteine protease StiP family protein	A0A172Q0S8	Acinetobacter_phage	2.8e-38	34.1
WP_001040059.1\|117128_117902_-	hypothetical protein	NA	NA	NA	NA
WP_001285478.1\|117894_119037_-	hypothetical protein	A0A172Q0Y1	Acinetobacter_phage	1.7e-30	35.4
WP_001035162.1\|119046_120105_-	hypothetical protein	NA	NA	NA	NA
WP_042634303.1\|120428_121010_+	tellurium resistance protein TerZ	K4JRX3	Caulobacter_phage	6.3e-13	30.0
WP_001054787.1\|121009_122167_+	tellurium resistance protein TerA	NA	NA	NA	NA
WP_000007448.1\|122189_122645_+	tellurite resistance TerB family protein	NA	NA	NA	NA
WP_062914744.1\|122667_123708_+	tellurium resistance membrane protein TerC	K7QKE8	Escherichia_phage	2.2e-77	48.0
WP_000116677.1\|123756_124335_+	tellurium resistance membrane protein TerD	A0A2P1N0L4	Streptomyces_phage	3.3e-06	40.0
WP_000301242.1\|124402_124978_+	TerD family protein	K4JRX3	Caulobacter_phage	8.7e-31	41.6
WP_001053338.1\|125406_126648_+	tellurium resistance protein TerF	NA	NA	NA	NA
WP_000077926.1\|127210_127492_-	hypothetical protein	NA	NA	NA	NA
WP_000398480.1\|127541_127733_-	hypothetical protein	NA	NA	NA	NA
WP_001371937.1\|127824_128196_-	hypothetical protein	NA	NA	NA	NA
WP_000341066.1\|128538_128931_+	hypothetical protein	NA	NA	NA	NA
WP_071624349.1\|128909_129221_+	hypothetical protein	NA	NA	NA	NA
WP_024136327.1\|129534_129828_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000088046.1\|129832_131158_+	type II toxin-antitoxin system HipA family toxin	NA	NA	NA	NA
WP_000134171.1\|131218_131425_+	hypothetical protein	NA	NA	NA	NA
WP_000985911.1\|131526_131937_+	hypothetical protein	NA	NA	NA	NA
WP_053276223.1\|131949_132765_+	HNH endonuclease	G0X580	Salmonella_phage	1.9e-15	35.4
WP_001043843.1\|133018_133444_+	hypothetical protein	NA	NA	NA	NA
WP_001224687.1\|133992_134301_+	hypothetical protein	NA	NA	NA	NA
WP_000784387.1\|134316_135174_+	HNH endonuclease	G0X580	Salmonella_phage	3.9e-11	34.2
WP_071940961.1\|135235_135484_+	hypothetical protein	NA	NA	NA	NA
WP_077250418.1\|136022_136448_-	DUF4158 domain-containing protein	A0A1B0V7H9	Salmonella_phage	7.6e-08	47.2
WP_063120614.1\|137147_138281_-	permease	NA	NA	NA	NA
WP_001175593.1\|138386_138710_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_001067858.1\|139252_139957_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
WP_032193599.1\|139986_140691_+	replication initiation protein	I3WF20	Macacine_betaherpesvirus	6.4e-20	28.7
WP_076751466.1\|140893_141082_+	hypothetical protein	NA	NA	NA	NA
WP_000427623.1\|141263_142268_-\|transposase	IS110-like element IS4321 family transposase	NA	NA	NA	NA
WP_000105383.1\|142685_144122_-	glutathione synthase	NA	NA	NA	NA
WP_071525219.1\|144209_144398_-	hypothetical protein	NA	NA	NA	NA
WP_001067855.1\|144388_145093_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0

DBSCAN-SWA_3

148431 : 189020

Escherichia_phage(53.85%)

transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001389365.1\|148431_149196_-\|transposase	IS6-like element IS6100 family transposase	A0A077SL39	Escherichia_phage	4.3e-86	65.7
WP_001067858.1\|149363_150068_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.2e-138	99.6
WP_000490638.1\|150385_151051_-	hypothetical protein	NA	NA	NA	NA
WP_001426317.1\|151108_151489_-	hypothetical protein	NA	NA	NA	NA
WP_000193209.1\|152131_152950_+	DUF4942 domain-containing protein	NA	NA	NA	NA
WP_001572381.1\|152946_154152_+	hypothetical protein	NA	NA	NA	NA
WP_000121165.1\|154215_154419_-	hypothetical protein	NA	NA	NA	NA
WP_000078514.1\|154431_155751_-	DUF1173 family protein	NA	NA	NA	NA
WP_000833382.1\|156001_157429_-	DNA cytosine methyltransferase	E5E3X6	Burkholderia_phage	3.4e-100	52.3
WP_001572389.1\|157643_158159_+	thermonuclease family protein	A0A1X6WF84	Pacmanvirus	2.1e-07	38.6
WP_000975182.1\|158161_159058_+	hypothetical protein	NA	NA	NA	NA
WP_015059496.1\|159279_159513_+	hypothetical protein	NA	NA	NA	NA
WP_001046767.1\|159558_159813_+	hypothetical protein	NA	NA	NA	NA
WP_024136338.1\|159850_160138_+	hypothetical protein	NA	NA	NA	NA
WP_001572393.1\|160174_160405_+	hypothetical protein	NA	NA	NA	NA
WP_000185304.1\|160741_161203_+	hypothetical protein	NA	NA	NA	NA
WP_000074418.1\|161232_161640_+	hypothetical protein	NA	NA	NA	NA
WP_029698059.1\|161690_162008_-	hypothetical protein	NA	NA	NA	NA
WP_031613424.1\|162384_162735_-	hypothetical protein	NA	NA	NA	NA
WP_001067855.1\|164424_165129_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_071448054.1\|165134_165881_+	winged helix family transcriptional regulator	NA	NA	NA	NA
WP_014839979.1\|165880_166399_+	hypothetical protein	NA	NA	NA	NA
WP_014839980.1\|166403_166820_-	fosfomycin resistance glutathione transferase FosA3	Q2LI91	Bacillus_phage	2.0e-08	35.6
WP_001617865.1\|167431_168307_-	class A extended-spectrum beta-lactamase CTX-M-14	A0A1B0VBP7	Salmonella_phage	6.1e-153	99.6
WP_001067855.1\|168609_169314_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_001199192.1\|169427_170204_+	aminoglycoside N-acetyltransferase AAC(3)-IV	NA	NA	NA	NA
WP_000171321.1\|170224_170446_+	hypothetical protein	NA	NA	NA	NA
WP_000742814.1\|170432_171458_+	aminoglycoside O-phosphotransferase APH(4)-Ia	NA	NA	NA	NA
WP_000602738.1\|171879_172632_-\|transposase	IS6 family transposase	A0A077SL39	Escherichia_phage	2.4e-41	44.7
WP_006581703.1\|174442_174928_+	hypothetical protein	NA	NA	NA	NA
WP_085940648.1\|175124_176215_-\|transposase	IS4 family transposase ISAba1	NA	NA	NA	NA
WP_110826437.1\|176304_177120_+	sulfonamide-resistant dihydropteroate synthase Sul2	A0A0B5J4J5	Pandoravirus	1.3e-08	27.2
WP_000251875.1\|177206_177509_+	phosphoglucosamine mutase	NA	NA	NA	NA
WP_001445143.1\|177402_177654_-	hypothetical protein	NA	NA	NA	NA
WP_015344975.1\|177684_179178_-\|transposase	IS91 family transposase	NA	NA	NA	NA
WP_001255015.1\|179289_179595_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_000214122.1\|179622_180837_-	chloramphenicol/florfenicol efflux MFS transporter FloR	S4TR35	Salmonella_phage	1.2e-18	28.7
WP_001447541.1\|181053_181938_-	DUF3363 domain-containing protein	NA	NA	NA	NA
WP_001067855.1\|182539_183244_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
WP_001317540.1\|185655_186372_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	2.4e-139	100.0
WP_001398199.1\|187682_188084_-	type II toxin-antitoxin system toxin endoribonuclease PemK	NA	NA	NA	NA
WP_000557619.1\|188016_188274_-	type II toxin-antitoxin system antitoxin PemI	NA	NA	NA	NA
WP_000616807.1\|188366_189020_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_4

257155 : 268636

Macacine_betaherpesvirus(33.33%)

transposase,integrase,protease

attL 245087:245103|attR 275952:275968

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
245087:245103	attL	NA	NA	NA	NA
WP_001066954.1\|257155_257896_-\|integrase	tyrosine-type recombinase/integrase	I3WFA4	Macacine_betaherpesvirus	1.2e-24	57.6
WP_001312821.1\|258016_258205_-	hypothetical protein	NA	NA	NA	NA
WP_000175738.1\|258578_259487_-	antimicrobial resistance protein Mig-14	NA	NA	NA	NA
WP_000771475.1\|259549_260659_-	NAD-dependent epimerase/dehydratase family protein	NA	NA	NA	NA
WP_001332051.1\|260717_261002_+	hypothetical protein	NA	NA	NA	NA
WP_000280980.1\|261091_262045_-\|protease	omptin family outer membrane protease	NA	NA	NA	NA
WP_001332050.1\|262148_262538_+\|protease	outer membrane protease	NA	NA	NA	NA
WP_001513519.1\|262904_263168_-	hypothetical protein	NA	NA	NA	NA
WP_077248528.1\|263317_263500_-\|transposase	transposase	NA	NA	NA	NA
WP_085949156.1\|263659_264872_+\|transposase	IS3 family transposase	Q6H9S3	Enterobacteria_phage	6.0e-167	98.6
WP_001259759.1\|266053_266257_-	hypothetical protein	NA	NA	NA	NA
WP_014640552.1\|266234_266471_-	colicin V immunity protein	NA	NA	NA	NA
WP_001105066.1\|266934_267216_-	hypothetical protein	NA	NA	NA	NA
WP_012478345.1\|267661_268636_-\|transposase	IS30-like element ISApl1 family transposase	W5R8L2	Staphylococcus_phage	2.3e-52	39.1
275952:275968	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP041996

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP041997

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection