CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP043391	Staphylococcus aureus strain NRS384-rpoB-H481N-SCV plasmid pNRS384_2, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP043389	Staphylococcus aureus strain NRS384-rpoB-H481N-SCV chromosome, complete genome	9 crisprs	cas3,DinG,DEDDh,csa3,WYL	9	4	11	1
NZ_CP043390	Staphylococcus aureus strain NRS384-rpoB-H481N-SCV plasmid pNRS384_1, complete sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP043389_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_1

433777-433877

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043389_1

>merge|NZ_CP043389|1|433777-433877|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>NZ_CP043389|1|1|433777-433877|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_000956132.1\|433893_434850_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235334
NZ_CP043389.1\|WP_000793009.1\|437270_438539_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468
NZ_CP043389.1\|WP_000930486.1\|428092_429616_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
NZ_CP043389.1\|WP_000052781.1\|429631_430201_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
NZ_CP043389.1\|WP_001789518.1\|433001_433103_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_001795623.1\|427720_428014_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_001289311.1\|430692_431448_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
NZ_CP043389.1\|WP_000746687.1\|427021_427648_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
NZ_CP043389.1\|WP_000421410.1\|436692_437271_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
NZ_CP043389.1\|WP_001802787.1\|433310_433568_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000394698.1\|434967_435630_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000763768.1\|435772_436180_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378584
NZ_CP043389.1\|WP_000159787.1\|443753_444026_-\|transposase	unknown	unknown	gnl\|CDD\|225511
NZ_CP043389.1\|WP_000551776.1\|441721_442258_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000041883.1\|442650_443355_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP043389.1\|WP_000158371.1\|425736_426318_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_CP043389.1\|WP_000264071.1\|438576_440043_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NZ_CP043389.1\|WP_000424966.1\|440067_441609_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP043389.1\|WP_000991007.1\|431528_432917_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
NZ_CP043389.1\|WP_000868248.1\|426383_426767_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000956132.1\|433893_434850_-\|hypothetical-protein	gnl\|CDD\|235334	PRK05035, PRK05035, electron transport complex protein RnfC; Provisional.	0.000748442
NZ_CP043389.1\|WP_000930486.1\|428092_429616_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
NZ_CP043389.1\|WP_000991007.1\|431528_432917_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
NZ_CP043389.1\|WP_001289311.1\|430692_431448_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	5.03864e-88
NZ_CP043389.1\|WP_000746687.1\|427021_427648_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.67126e-71
NZ_CP043389.1\|WP_000793009.1\|437270_438539_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	2.75897e-170
NZ_CP043389.1\|WP_000421410.1\|436692_437271_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.01486e-119
NZ_CP043389.1\|WP_000763768.1\|435772_436180_-\|hypothetical-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.0219e-12
NZ_CP043389.1\|WP_000159787.1\|443753_444026_-\|transposase	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	9.23077e-11
NZ_CP043389.1\|WP_000158371.1\|425736_426318_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	7.98269e-49
NZ_CP043389.1\|WP_000264071.1\|438576_440043_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NZ_CP043389.1\|WP_000052781.1\|429631_430201_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124
NZ_CP043389.1\|WP_000424966.1\|440067_441609_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP043389.1\|WP_000041883.1\|442650_443355_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	9.65175e-08

>NZ_CP043389.1|WP_001802787.1|433310_433568_-|hypothetical-protein
MLVTDESHKCTLIFTFTTNAFLLKQKYLFTVAFELPPAHTNTQKMLILIRQNFLQRVCSKRLFKVDHLLSFHSINMRLAIFIKPP
>NZ_CP043389.1|WP_001789518.1|433001_433103_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNSVVIGGKGK
>NZ_CP043389.1|WP_000991007.1|431528_432917_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLIYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKRAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLIILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFDSNDNAALTSH
>NZ_CP043389.1|WP_001289311.1|430692_431448_+|NADPH-dependent-oxidoreductase
MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
>NZ_CP043389.1|WP_000052781.1|429631_430201_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>NZ_CP043389.1|WP_000930486.1|428092_429616_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDDKSKELKDLLTEITDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKKLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMNTGEEHLLNLDGIFVQIGLLPNTSWLNDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>NZ_CP043389.1|WP_001795623.1|427720_428014_-|hypothetical-protein
MINLIYTTRCAIMLKVCTSRKQINMKNDIEKEKYVNEIIMLLRTIPTSKLVQPIMQLFIDKAILNNVQNDALLIEKATHARNHLRLWSLQGHRDIPN
>NZ_CP043389.1|WP_000746687.1|427021_427648_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASTLILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>NZ_CP043389.1|WP_000868248.1|426383_426767_-|hypothetical-protein
MKVRITFIILAILSTIVCLFLAAMHPTGPNTVTFEQPYLFTLNIIIMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFTSTIITLAIGGKSVEKNDSP
>NZ_CP043389.1|WP_000158371.1|425736_426318_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYDKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQKDDIVIVAHQVVIRCLMVYFNKVSRAEAVDLKVENCKPYIIE
>NZ_CP043389.1|WP_000956132.1|433893_434850_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLLGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKALAESTNKVEKNAVTEDKADSKDSKVAGVNTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNDNAAETSNKEATVDAEAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>NZ_CP043389.1|WP_000394698.1|434967_435630_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEEMDLRKPF
>NZ_CP043389.1|WP_000763768.1|435772_436180_-|hypothetical-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHQEVHENNSAYEEIDITHFAEASKGPKA
>NZ_CP043389.1|WP_000421410.1|436692_437271_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
>NZ_CP043389.1|WP_000793009.1|437270_438539_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILLLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVK
>NZ_CP043389.1|WP_000264071.1|438576_440043_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>NZ_CP043389.1|WP_000424966.1|440067_441609_+|glutamine-hydrolyzing-GMP-synthase
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCRGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>NZ_CP043389.1|WP_000551776.1|441721_442258_-|hypothetical-protein
MHNNNEFNKKLKDFIGSDKRMALVKGYVNEYKLTTVLRALNNSDYTKGTIHTRSIGNLKQIVDNRIIPKNITQNTIFKLSNLTLEVNLYERNTIYHGDFAIYYPVESALIIETDTPRLINHINNNPVQKIFIITTNDWSFNTLELEKIVDETIIYDLKQEDPKQYEILYKNKHGKLPY
>NZ_CP043389.1|WP_000041883.1|442650_443355_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MSKNINQANSKLNTSNKKLKQAYSKSDSKNMKVIYMPHWLEFYSIAIHSDVTSNKKRYYKSYSRGTVVYVKLGSNIGSEFSGNHFCVILDNKDNKGKETVTIVPLSSKGNKNYLKLNESVLNLTATDLKKQIIDISSKVQALAQKYREIDIKLSTEDKKLLSNLNQKANELYRVIGVYSKHKGKDTYVNISAITTISKRRISKINDSDPTGTIIISEDDMNEIEKQLKIKFFSN
>NZ_CP043389.1|WP_000159787.1|443753_444026_-|transposase
MTKERRTFSSEFKLQMVRLYKNGKLKNEIIRKYDLKPSIISNSIKQHQNTGPFNHQDNLKSDEKELIKLRKEVQHLKMEHDVLKQILKLI

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Crispr_ID: NZ_CP043389_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_2

1442080-1442388

Orphan

Consensus_repeat	Method
CCAACTTGCANNNTNTNNNNAGCTGNCTTT	CRT
CCAGCCTCTGTGTTGGGGCCCCG	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP043389_2

>merge|NZ_CP043389|2|1442080-1442388|CRT,CRISPRCasFinder
CCAAATTGAAATTATCCTACTGCTGTCTTTTTGGGAGTGGGACAGAAATGATATTTTCGCAAAATTTATTTCGTCGTCCCACCCCAACTTGCACACTATTGTAAGCTGACTTTTCGCCAGCTTCTGTGTTGGGGCCCCGCCAACTTGCATTGTCTGTAGAAATTGAGGAGCTAATTTCTCTGTGTCGGGGCTCCACCCCAACTTGCACACTATTGTAAGCTGACTTTCCGCCAGCCTCTGTGTTGGGGCCCCGCCAACTTGCACACTATTGTAAGCTGACTTTCCACCAGCCTCTGTGTTGGGGCCCCG

>NZ_CP043389|2|1|1442080-1442362|CRT
CCAAATTGAAATTATCCTACTGCTGTCTTT	TTGGGAGTGGGACAGAAATGATATTTTCGCAAAATTTATTTCGTCGTCCCACC
CCAACTTGCACACTATTGTAAGCTGACTTT	TCGCCAGCTTCTGTGTTGGGGCCCCG
CCAACTTGCATTGTCTGTAGAAATTGAGGA	GCTAATTTCTCTGTGTCGGGGCTCCACC
CCAACTTGCACACTATTGTAAGCTGACTTT	CCGCCAGCCTCTGTGTTGGGGCCCCG
CCAACTTGCACACTATTGTAAGCTGACTTT

>NZ_CP043389|2|2|1442310-1442388|CRISPRCasFinder
CCAGCCTCTGTGTTGGGGCCCCG	CCAACTTGCACACTATTGTAAGCTGACTTTCCA
CCAGCCTCTGTGTTGGGGCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_000758215.1\|1435153_1435678_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_CP043389.1\|WP_001081626.1\|1451214_1451643_+\|Na(+)/H(+)-antiporter-subunit-B	unknown	unknown	gnl\|CDD\|183602
NZ_CP043389.1\|WP_000711486.1\|1434562_1435138_-\|signal-peptidase-I	unknown	unknown	gnl\|CDD\|274044
NZ_CP043389.1\|WP_000035058.1\|1447645_1448239_-\|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl\|CDD\|238908
NZ_CP043389.1\|WP_001067294.1\|1446852_1447230_-\|S1-RNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224023
NZ_CP043389.1\|WP_000781156.1\|1448302_1448686_+\|kinase	unknown	unknown	gnl\|CDD\|378054
NZ_CP043389.1\|WP_000148855.1\|1436582_1437914_-\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|184504
NZ_CP043389.1\|WP_000172342.1\|1430926_1434403_-\|helicase-exonuclease-AddAB-subunit-AddB	unknown	unknown	gnl\|CDD\|213736
NZ_CP043389.1\|WP_000573080.1\|1451976_1453473_+\|Na+/H+-antiporter-subunit-D	unknown	unknown	gnl\|CDD\|181085
NZ_CP043389.1\|WP_000660045.1\|1438264_1439470_+\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NZ_CP043389.1\|WP_000838037.1\|1445363_1446491_-\|NADH-dependent-flavin-oxidoreductase	unknown	unknown	gnl\|CDD\|240086
NZ_CP043389.1\|WP_000185319.1\|1441080_1442010_+\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176543
NZ_CP043389.1\|WP_000054609.1\|1448816_1451222_+\|Na+/H+-antiporter-subunit-A	unknown	unknown	gnl\|CDD\|237155
NZ_CP043389.1\|WP_000066062.1\|1439459_1440839_+\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_CP043389.1\|WP_000154914.1\|1427272_1430926_-\|helicase-exonuclease-AddAB-subunit-AddA	unknown	unknown	gnl\|CDD\|274299
NZ_CP043389.1\|WP_000138486.1\|1442512_1443757_-\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NZ_CP043389.1\|WP_000007967.1\|1435682_1436258_-\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_CP043389.1\|WP_011443624.1\|1451654_1451984_+\|Na(+)/H(+)-antiporter-subunit-C	unknown	unknown	gnl\|CDD\|181497
NZ_CP043389.1\|WP_000670752.1\|1426204_1427107_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223257
NZ_CP043389.1\|WP_000167314.1\|1443865_1445056_-\|ornithine--oxo-acid-transaminase	unknown	unknown	gnl\|CDD\|179736

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000758215.1\|1435153_1435678_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	2.63848e-48
NZ_CP043389.1\|WP_001081626.1\|1451214_1451643_+\|Na(+)/H(+)-antiporter-subunit-B	gnl\|CDD\|183602	PRK12573, PRK12573, Na(+)/H(+) antiporter subunit B.	9.17513e-61
NZ_CP043389.1\|WP_000711486.1\|1434562_1435138_-\|signal-peptidase-I	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	4.05406e-53
NZ_CP043389.1\|WP_000035058.1\|1447645_1448239_-\|peptidyl-prolyl-cis-trans-isomerase	gnl\|CDD\|238908	cd01927, cyclophilin_WD40, cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the protein is not known.	3.93388e-65
NZ_CP043389.1\|WP_001067294.1\|1446852_1447230_-\|S1-RNA-binding-domain-containing-protein	gnl\|CDD\|224023	COG1098, VacB, Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis].	3.22125e-44
NZ_CP043389.1\|WP_000781156.1\|1448302_1448686_+\|kinase	gnl\|CDD\|378054	pfam08810, KapB, Kinase associated protein B. This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.	1.89892e-52
NZ_CP043389.1\|WP_000148855.1\|1436582_1437914_-\|glucose-6-phosphate-isomerase	gnl\|CDD\|184504	PRK14097, pgi, glucose-6-phosphate isomerase; Provisional.	0
NZ_CP043389.1\|WP_000172342.1\|1430926_1434403_-\|helicase-exonuclease-AddAB-subunit-AddB	gnl\|CDD\|213736	TIGR02773, ATP-dependent_helicase/deoxyribonuclease_subunit_B, helicase-exonuclease AddAB, AddB subunit. DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RexAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. Nevertheless, the partner is designated AddB in both systems. This model describes the AddB protein as found Bacillus subtilis and related species. Although the RexB protein of Streptococcus and Lactococcus is considered to be orthologous, functionally equivalent, and merely named differently, all members of this protein family have a P-loop nucleotide binding motif GxxGxGK[ST] at the N-terminus, unlike RexB proteins, and a CxxCxxxxxC motif at the C-terminus, both of which may be relevant to function. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP043389.1\|WP_000573080.1\|1451976_1453473_+\|Na+/H+-antiporter-subunit-D	gnl\|CDD\|181085	PRK07691, PRK07691, putative monovalent cation/H+ antiporter subunit D; Reviewed.	0
NZ_CP043389.1\|WP_000660045.1\|1438264_1439470_+\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NZ_CP043389.1\|WP_000838037.1\|1445363_1446491_-\|NADH-dependent-flavin-oxidoreductase	gnl\|CDD\|240086	cd04735, OYE_like_4_FMN, Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.	0
NZ_CP043389.1\|WP_000185319.1\|1441080_1442010_+\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176543	cd08601, GDPD_SaGlpQ_like, Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized glycerophosphodiester phosphodiesterase (GP-GDE, EC 3.1.4.46) from Staphylococcus aureus, Bacillus subtilis and similar proteins. Members in this family show very high sequence similarity to Escherichia coli periplasmic phosphodiesterase GlpQ, which catalyzes the Ca2+-dependent degradation of periplasmic glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	5.11302e-151
NZ_CP043389.1\|WP_000054609.1\|1448816_1451222_+\|Na+/H+-antiporter-subunit-A	gnl\|CDD\|237155	PRK12645, PRK12645, monovalent cation/H+ antiporter subunit A; Reviewed.	0
NZ_CP043389.1\|WP_000066062.1\|1439459_1440839_+\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_CP043389.1\|WP_000154914.1\|1427272_1430926_-\|helicase-exonuclease-AddAB-subunit-AddA	gnl\|CDD\|274299	TIGR02785, ATP-dependent_helicase/nuclease_subunit_A, helicase-exonuclease AddAB, AddA subunit, Firmicutes type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP043389.1\|WP_000138486.1\|1442512_1443757_-\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	0
NZ_CP043389.1\|WP_000007967.1\|1435682_1436258_-\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	1.01759e-40
NZ_CP043389.1\|WP_011443624.1\|1451654_1451984_+\|Na(+)/H(+)-antiporter-subunit-C	gnl\|CDD\|181497	PRK08600, PRK08600, putative monovalent cation/H+ antiporter subunit C; Reviewed.	3.20641e-61
NZ_CP043389.1\|WP_000670752.1\|1426204_1427107_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.0042e-87
NZ_CP043389.1\|WP_000167314.1\|1443865_1445056_-\|ornithine--oxo-acid-transaminase	gnl\|CDD\|179736	PRK04073, rocD, ornithine--oxo-acid transaminase; Provisional.	0

>NZ_CP043389.1|WP_000185319.1|1441080_1442010_+|glycerophosphodiester-phosphodiesterase
MTNSSKSFTKFMAASAVFTMGFLSVPTAGAEQTNQIANKPQAIQWHTNLTNERFTTIAHRGASGYAPEHTFQAYDKSHNELKASYIEIDLQRTKDGHLVAMHDETVNRTTNGHGKVEDYTLDELKQLDAGSWFNKKYPKYARASYKNAKVPTLDEILERYGPNANYYIETKSPDVYPGMEEQLLASLKKHHLLNNNKLKNGHVMIQSFSDESLKKIHRQNKHVPLVKLVDKGELQQFNDQRLKEIRSYAIGLGPDYTDLTEQNTHHLKDLGFIVHPYTVNEKADMLRLNKYGVDGVFTNFADKYKEVIK
>NZ_CP043389.1|WP_000066062.1|1439459_1440839_+|argininosuccinate-lyase
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPSYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
>NZ_CP043389.1|WP_000660045.1|1438264_1439470_+|argininosuccinate-synthase
MKEKIVLAYSGGLDTSVAVQWLIDKGYDVVACCLDVGEGKDLDIVYKKALDMGAVECHIIDATKEFSDEYVSYAIKGNLMYENAYPLVSALSRPLIAKKLVEIAEKTNSVGIAHGCTGKGNDQVRFEVAIKALNPSLKAFAPVREWAWSREEEIDYAIKHNIPVSINHDSPYSIDQNLWGRANECGILEDPYAAPPEDAFDLTNALEETPDTADEIILTFDKGIPVQIDGKTYELDDLILTLNALAGKHGIGRIDHVENRLVGIKSREIYEAPAAEVILKAHKALETITLTKDVAHFKPIIEKQFAEQLYNGLWFSPLTDSLKLFIDSTQQYVSGDVRIKLFKGNAIVNGRKSPYTLYDEKLATYTKEDAFNQDAAVGFIDIYGLPTQVNAMLHGGYSNEQ
>NZ_CP043389.1|WP_000148855.1|1436582_1437914_-|glucose-6-phosphate-isomerase
MTHIQLDFSKTLEFFGEHELKQQQEIVKSIHKTIHEGTGAGSDFLGWVDLPVDYDKEEFSRIVEASKRIKENSDVLVVIGIGGSYLGARAAIEMLTSSFRNSNEYPEIVFVGNHLSSTYTKELVDYLADKDFSVNVISKSGTTTEPAVAFRLFKQLVEERYGKEEAQKRIFATTDKEKGALKQLATNEGYETFIVPDDVGGRYSVLTAVGLLPIATAGINIEAMMIGAAKAREELSSDKLEENIAYQYATIRNILYAKGYTTEMLINYEPSMQYFNEWWKQLFGESEGKDFKGIYPSSANYTTDLHSLGQYVQEGRRFLFETVVKVNHPKYDITIEKDSDDLDGLNYLAGKTIDEVNTKAFEGTLLAHTDGGVPNMVVNIPQLDEETFGYVVYFFELACAMSGYQLGVNPFNQPGVEAYKQNMFALLGKPGFEDLKKELEERL
>NZ_CP043389.1|WP_000007967.1|1435682_1436258_-|TVP38/TMEM64-family-protein
MSFHQVEEWFEIFRQFGYLPGFILLYIRAIIPVFPLALYILINIQAYGPILGILISWLGLISGTFTVYLICKRLVNTERMQRIKQRTAVQRLISFIDRQGLIPLFILLCFPFTPNTLINFVASLSHIRPKYYFIVLASSKLVSTIILGYLGKEITTILTHPLRGILMLVVLVVFWIVGKKLEQHFMGSKKE
>NZ_CP043389.1|WP_000758215.1|1435153_1435678_-|signal-peptidase-I
MKKVVKYLISLILAIIIVLFVQTFVIVGHVIPNNDMSPTLNKGDRVIVNKIKVTFNQLNNGDIITYRRGNEIYTSRIIAKPGQSMAFRQGQLYRDDRPVDASYAKNRKIKDFSLRNFKELDGDIIPPNNFVVLNDQDNNKHDSRQFGLIDKKDIIGNVSLRYYPFSKWTVQFKS
>NZ_CP043389.1|WP_000711486.1|1434562_1435138_-|signal-peptidase-I
MKKEILEWIISIAVAFVILFIVGKFIVTPYTIKGESMDPTLKDGERVAVNIVGYKTGGLEKGNVVVFHANKNDDYVKRVIGVPGDKVEYKNDTLYVNGKKQDEPYLNYNLKHKQGDYITGTFQVKDLPNANPKSNVIPKGKYLVLGDNREVSKDSRAFGLIDEDQIVGKVSFRFWPFSEFKHNFNPENTKN
>NZ_CP043389.1|WP_000172342.1|1430926_1434403_-|helicase-exonuclease-AddAB-subunit-AddB
MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLEHFIADKNMQTRTKNKLEDIALIYREFEQRIQNEFITGEDSLQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEIANELNISIERQYFNQLYRFNNQDLKHLEQEFDALQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQVNPMLRLLKTDVLTASYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKAHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAETVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYFEQQANVELSPTSDILQMDEAFVCYVAMTRAKGDVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLYDEIVADSWLDAYQVIRDSDHLNQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWSDIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGEQ
>NZ_CP043389.1|WP_000154914.1|1427272_1430926_-|helicase-exonuclease-AddAB-subunit-AddA
MTIPEKPQGVIWTDAQWQSIYATGQDVLVAAAAGSGKTAVLVERIIQKILRDGIDVDRLLVVTFTNLSAREMKHRVDQRIQEASIADPANAHLKNQRIKIHQAQISTLHSFCLKLIQQHYDVLNIDPNFRTSSEAENILLLEQTIDEVIEQHYDILDPAFIELTEQLSSDRSDDQFRMIIKQLYFFSVANPNPKNWLDQLVTPYEEEAQQAQLIQLLTDLSKVFITAAYDALNKAYDLFSMMDSVDKHLAVIEDERRLMGRVLEGGFIDIPYLTGHEFGARLPNVTAKIKEANEMMVDALEDAKLQYKKYKSLIDKVKSDYFSREADDLKADMQQLAPRVKYLARIVKDVMSEFNRKKRSKNILDFSDYEHFALQILTNEDGSPSEIAESYRQHFQEILVDEYQDTNRVQEKILSCIKTGDEHNGNLFMVGDVKQSIYKFRQADPSLFIEKYQRFTIDGDGTGRRIDLSQNFRSRKEVLSTTNYIFKHMMDEQVGEVKYDEAAQLYYGAPYDESDHPVNLKVLVEADQEHSDLTGSEQEAHFIVEQVKDILEHQKVYDMKTGSYRSATYKDIVILERSFGQARNLQQAFKNEDIPFHVNSREGYFEQTEVRLVLSFLRAIDNPLQDIYLVGLMRSVIYQFKEDELAQIRILSPNDDYFYQSIVNYINDEAADAILVDKLKMFLSDIQSYQQYSKDHPVYQLIDKFYNDHYVIQYFSGLIGGRGRRANLYGLFNKAIEFENSSFRGLYQFIRFIDELIERGKDFGEENVVGPNDNVVRMMTIHSSKGLEFPFVIYSGLSKDFNKRDLKQPVILNQQFGLGMDYFDVDKEMAFPSLASVAYRAVAEKELVSEEMRLVYVALTRAKEQLYLIGRVKNDKSLLELEQLSISGEHIAVNERLTSPNPFHLIYSILSKHQSASIPDDLKFEKDIAQIEDSSRPNVNISIVYFEDVSTETILDNDEYRSVNQLETMQNGNEDVKAQIKHQLDYRYPYVNDTKKPSKQSVSELKRQYETEESGTSYERVRQYRIGFSTYERPKFLSEQGKRKANEIGTLMHTVMQHLPFKKERISEVELHQYIDGLIDKHIIEADAKKDIRMDEIMTFINSELYSIIAEAEQVYRELPFVVNQALVDQLPQGDEDVSIIQGMIDLIFVKDGVHYFVDYKTDAFNRRRGMTDEEIGTQLKNKYKIQMKYYQNTLQTILNKEVKGYLYFFKFGTLQL
>NZ_CP043389.1|WP_000670752.1|1426204_1427107_-|fumarylacetoacetate-hydrolase-family-protein
MKFLSFKYNDKTSYGVKVKREDAVWDLTQVFADFAEGDFHPKTLLAGLQQNHTLDFQEQVRKAVVAAEDSGKAEDYKISFNDIEFLPPVTPPNNVIAFGRNYKDHANELNHEVEKLYVFTKAASSLTGDNATIPNHKDITDQLDYEGELGIVIGKSGEKIPKALALDYVYGYTIINDITDRKAQSEQDQAFLSKSLTGGCPMGPYIVTKDELPLPENVNIVTKVNNEIRQDGNTGEMILKIDELIEEISKYVALHPGDIIATGTPAGVGAGMQPPKFLQPGDEVKVTIDNIGTLTTYIAK
>NZ_CP043389.1|WP_000138486.1|1442512_1443757_-|Glu/Leu/Phe/Val-dehydrogenase
MTENNNLVTSTQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKFNSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKRRNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIVVEAANGPTTPEATRILTERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVDEKLREKLEAAFDTIYELSQNRKIDMRLAAYIIGIKRTAEAARYRGWA
>NZ_CP043389.1|WP_000167314.1|1443865_1445056_-|ornithine--oxo-acid-transaminase
MTKSEKIIELTNHYGAHNYLPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKDQADKVTLVSRAFHSDNLGEWYEKICKLAGKDKALPMNTGAEAVETALKAARRWAYDVKGIEPNKAEIIAFNGNFHGRTMAPVSLSSEAEYQRGYGPLLDGFRKVDFGDVDALKAAINENTAAVLVEPIQGEAGINIPPEGYLKAIRELCDEHNVLFIADEIQAGLGRSGKLFATDWDNVKPDVYILGKALGGGVFPISVVLADKEVLDVFTPGSHGSTFGGNPLACAASIAALDVIVDEDLPGRSLELGDYFKEQLKQIDHPSIKEVRGRGLFIGVELNESARPYCEALKEEGLLCKETHDTVIRFAPPLIITKEELDLALEKIRHVFQ
>NZ_CP043389.1|WP_000838037.1|1445363_1446491_-|NADH-dependent-flavin-oxidoreductase
MKSKYEPLFDKVELPNGVELRNRFVLAPLTHISSNDDGTISDVELPYIEKRSQDVGITINAASNVSDVGKAFPGQPSIAHDSNIEGLKRLATAMKKNGAKALVQIHHGGAQALPELTPDGDVVAPSPISLKSFGQKQEHSAREMTNEEIEQAIKDFGEATRRAIEAGFDGVEIHGANHYLIHQFVSPYYNRRNDVWANQYKFPVAVIEEVLKAKEAYGNKDFIVGYRLSPEEAESPGITMEITEELVNKISHMPIDYIHVSMMDTHATTREGKYAGQERLPLIHKWINGRMPLIGIGSIFTADEALDAVENVGVDLVAIGRELLLDYQFVEKIKDGREDEIINYFDPEREDNHHLTPNLWHQFNEGFYPLPRKDK
>NZ_CP043389.1|WP_001067294.1|1446852_1447230_-|S1-RNA-binding-domain-containing-protein
MNNYKIGQHIKVRVTGIQPYGAFVETPNHTEGLIHISEIMDDYVHNLKKFLSEGQIVKAKILSIDDEGKLNLSLKDNDYFKNYERKKEKQSVLDEIRETEKYGFQTLKERLPIWIKQSKRAIRND
>NZ_CP043389.1|WP_000035058.1|1447645_1448239_-|peptidyl-prolyl-cis-trans-isomerase
MANYPQLNKEVQQGEIKVVMHTNKGDMTFKLFPNIAPKTVENFVTHAKNGYYDGITFHRVINDFMIQGGDPTATGMGGESIYGGAFEDEFSLNAFNLYGALSMANSGPNTNGSQFFIVQMKEVPQNMLSQLADGGWPQPIVDAYGEKGGTPWLDQKHTVFGQIIDGETTLEDIANTKVGPQDKPLHDVVIESIDVEE
>NZ_CP043389.1|WP_000781156.1|1448302_1448686_+|kinase
MKLYRFSHKTGSYGVTIVEENGDDVLVKVEQVIKHPKQGDLHNPTETEGVFFHDRKALSHFEKRYTKRSQLRDFNVDVLRYEDSLQQAITDLETKLKAQQTKHAEMSLASLARLKEDYSLQYKENFK
>NZ_CP043389.1|WP_000054609.1|1448816_1451222_+|Na+/H+-antiporter-subunit-A
MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVFGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
>NZ_CP043389.1|WP_001081626.1|1451214_1451643_+|Na(+)/H(+)-antiporter-subunit-B
MNRQQNDLILQFAAVIIFFMVMVFGFSLFLAGHYTPGGGFVGGLLFASSLVIITIAFDIETMRKIFPLDFKILIGIGLVFCIATPIASWFLGKNFFTHVTFDIPLFILEPVHMTTAVFFDFGVLCAVVGTVMTIIISIGENE
>NZ_CP043389.1|WP_011443624.1|1451654_1451984_+|Na(+)/H(+)-antiporter-subunit-C
MIFVSGILTAISVYLVLSKSLIRIVMGTTLLTHAANLFLITMGGLKHGTVPIYEANVKSYVDPIPQALILTAIVIAFATTAFFLVLAFRTYKELGTDNVESMKGVPEDD
>NZ_CP043389.1|WP_000573080.1|1451976_1453473_+|Na+/H+-antiporter-subunit-D
MIESNMLVLTLVIPVITAILLVFIGKRPIIKRYVALGGTLLTLVAAIINLANVVKHGPIRVELGSWKAPYSIVFVLDIFSALLIITSIIITAIVILYSYQTIGIERERYYYYFSVLFMLIGIIGAFTTGDIFNLFVYFEVFLMSSYFLLVIGSTKIQLQETIKYVLVNVVSSSFFVMGVAILYSVVGTLNLADISNKLANLSAHDSGLVNIVFILFIFVFATKAGVFPMFVWLPSAYYAPPIPIIAFFGALLTKVGVYAIARTLSLFFSDNVSFSHYVILFLALLTIIFGCVGAVAYANIKKIILYNVMIAVGVILVGVAMMTESGMIGSIYYTLHDMLVKLALFLLIGIMIKITGTADLRQFGGLIKRYPVLGWSFFIAALSLAGIPPLSGFYGKFFIVQSTFERGFYLSGVIVLLSSLVVLYSVIRIFLQGFFGQPKGYDLNNKVDVKYLTTIAIVAVVITVLYGLSADYLYPMVKAGAETFYNPSTYVKAVLGGK

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Crispr_ID: NZ_CP043389_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_3

1505092-1505173

Orphan

Consensus_repeat	Method
TTCTACAGGCAATGCAAGTTGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043389_3

>merge|NZ_CP043389|3|1505092-1505173|CRISPRCasFinder
TTCTACAGGCAATGCAAGTTGGGGATGGGCCCCAACAAAGAGAAATTGGATTCCCAATTTCTACAGACAATGCAAGTTGGGG

>NZ_CP043389|3|3|1505092-1505173|CRISPRCasFinder
TTCTACAGGCAATGCAAGTTGGGG	ATGGGCCCCAACAAAGAGAAATTGGATTCCCAAT
TTCTACAGACAATGCAAGTTGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_001260004.1\|1497307_1497640_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP043389.1\|WP_000266158.1\|1499694_1500915_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP043389.1\|WP_000571218.1\|1502584_1503610_-\|methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224058
NZ_CP043389.1\|WP_000281658.1\|1497651_1498110_+\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_CP043389.1\|WP_000520233.1\|1501896_1502592_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
NZ_CP043389.1\|WP_000589549.1\|1506871_1507228_-\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
NZ_CP043389.1\|WP_000732326.1\|1501057_1501879_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP043389.1\|WP_000255561.1\|1510797_1511415_+\|amino-acid-transporter	unknown	unknown	gnl\|CDD\|224198
NZ_CP043389.1\|WP_001033321.1\|1498126_1498855_+\|staphylococcal-enterotoxin-type-Q	unknown	unknown	gnl\|CDD\|280949
NZ_CP043389.1\|WP_000734020.1\|1498878_1499607_+\|staphylococcal-enterotoxin-type-K	unknown	unknown	gnl\|CDD\|280949
NZ_CP043389.1\|WP_001190695.1\|1507371_1507692_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP043389.1\|WP_000290485.1\|1506333_1506714_-\|glycine-cleavage-system-protein-GcvH	unknown	unknown	gnl\|CDD\|234918
NZ_CP043389.1\|WP_000422909.1\|1507841_1508381_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
NZ_CP043389.1\|WP_001065801.1\|1503859_1504156_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP043389.1\|WP_000974460.1\|1509327_1509750_+\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NZ_CP043389.1\|WP_001018962.1\|1504148_1504535_-\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
NZ_CP043389.1\|WP_000932219.1\|1505276_1506155_-\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
NZ_CP043389.1\|WP_000150017.1\|1508463_1509180_-\|type-I-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|184156
NZ_CP043389.1\|WP_000660172.1\|1506156_1506270_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000569884.1\|1510148_1510643_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_001260004.1\|1497307_1497640_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.56309e-09
NZ_CP043389.1\|WP_000266158.1\|1499694_1500915_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	9.89414e-38
NZ_CP043389.1\|WP_000571218.1\|1502584_1503610_-\|methionine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	3.37873e-170
NZ_CP043389.1\|WP_000281658.1\|1497651_1498110_+\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	0.00223487
NZ_CP043389.1\|WP_000520233.1\|1501896_1502592_-\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	9.67625e-100
NZ_CP043389.1\|WP_000589549.1\|1506871_1507228_-\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
NZ_CP043389.1\|WP_000732326.1\|1501057_1501879_-\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.15951e-112
NZ_CP043389.1\|WP_000255561.1\|1510797_1511415_+\|amino-acid-transporter	gnl\|CDD\|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	9.12336e-62
NZ_CP043389.1\|WP_001033321.1\|1498126_1498855_+\|staphylococcal-enterotoxin-type-Q	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	1.46097e-28
NZ_CP043389.1\|WP_000734020.1\|1498878_1499607_+\|staphylococcal-enterotoxin-type-K	gnl\|CDD\|280949	pfam02876, Stap_Strp_tox_C, Staphylococcal/Streptococcal toxin, beta-grasp domain.	1.03678e-24
NZ_CP043389.1\|WP_001190695.1\|1507371_1507692_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.70086e-24
NZ_CP043389.1\|WP_000290485.1\|1506333_1506714_-\|glycine-cleavage-system-protein-GcvH	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	2.81086e-68
NZ_CP043389.1\|WP_000422909.1\|1507841_1508381_-\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	1.47647e-49
NZ_CP043389.1\|WP_001065801.1\|1503859_1504156_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	7.01368e-14
NZ_CP043389.1\|WP_001018962.1\|1504148_1504535_-\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	2.45102e-36
NZ_CP043389.1\|WP_000932219.1\|1505276_1506155_-\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	9.06932e-75
NZ_CP043389.1\|WP_000150017.1\|1508463_1509180_-\|type-I-3-dehydroquinate-dehydratase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	1.26721e-148
NZ_CP043389.1\|WP_000974460.1\|1509327_1509750_+\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	5.58225e-61
NZ_CP043389.1\|WP_000569884.1\|1510148_1510643_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47

>NZ_CP043389.1|WP_001018962.1|1504148_1504535_-|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPLLPNINNERLVLVNE
>NZ_CP043389.1|WP_001065801.1|1503859_1504156_-|thioredoxin-family-protein
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFKSVTDLLENLK
>NZ_CP043389.1|WP_000571218.1|1502584_1503610_-|methionine-ABC-transporter-ATP-binding-protein
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEQGPVTQVFENPQHTVTKRFVKDDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>NZ_CP043389.1|WP_000520233.1|1501896_1502592_-|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWTVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>NZ_CP043389.1|WP_000732326.1|1501057_1501879_-|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGNKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYELDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGDVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>NZ_CP043389.1|WP_000266158.1|1499694_1500915_+|site-specific-integrase
MWLEKFKNKNKETKYRYYEKYKDPLTAKWRRVSVVLNKNGKQSQKEAQRLLNERIEEKLNDKKPTTLKSLTFHVACDEWFQNYIKTSGSKRTTIKTKLSKLNTLKKFVDEDILINKITLSYAQQVFDEMDSKGYVYQVNKDALSIFKNVFEYTRRIYKLQDLEFLKDITLNKRIKSYDEVKAKRNKYLELNEIESIIKDINTKAQKMHSGIHKRFYLFVALMTEFQALNGMRIGEMLAIQNEDIDFDNKSLNINGTIHWFHDESGGFGVKDTTKTESSYRTIGLSSRSCEILKKAILENKKDSKWNDGYLNRNFVFTNHKGNPMQTERFNKILREAAKDVGIDKEVSSHILRHSHISLLSQQGVSLKAIMDRVGHSDHRTTLSIYSHVTEQMDKDMMNKLEQVKLG
>NZ_CP043389.1|WP_000734020.1|1498878_1499607_+|staphylococcal-enterotoxin-type-K
MKKLIVIILINIITLSVSNSASAQGDIGIDNLRNFYTKKDFVDLKDVKDNDTPIANQLQFSNVSYDLISESKDFNKFSNFKGKKLDVFGISYNGQCNNKYIYGGVTATNEYLDKPRNIPINIWINGNHKTISTNKVSTNKKFVTAQEIDVKLRKYLQEEYNIYGHNGTKKGEEYGHKSKFYSGFNIGKVTFHLNNNDTFSYDLFYTGDDGLPKSFLKIYEDNKTVESEKFHLDVDISYKETI
>NZ_CP043389.1|WP_001033321.1|1498126_1498855_+|staphylococcal-enterotoxin-type-Q
MNKIFRVLTVSLFFFTFLIKNNLAYADVGVINLRNFYTNYQPETLQGVSSGNFSTSHQLEYIDGKYTLYSQFHNEYEAKRLKDHKVDIFGISYSGLCNTKYMYGGITLANQNLDKPRNIPINLWVNGKQNTISTDEVSTQKKEVTAQEIDIKLRKYLQNEYNIYGFNKTKKGQEYGYQSKFNSGFNKGKITFHLNNETSFTYDLFYTGTGQAESFLKIYNDNKTIDAENFHLDVEISYEKTE
>NZ_CP043389.1|WP_000281658.1|1497651_1498110_+|ImmA/IrrE-family-metallo-endopeptidase
MYLYEKMVIENKEIPIDDGKSLGNFEGLYDNGVILINKNLSETRKAEVLYEELAHHKLTYGNILDQSKWINRKFENYARRHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEKYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
>NZ_CP043389.1|WP_001260004.1|1497307_1497640_+|helix-turn-helix-transcriptional-regulator
MRTNDEIITIIKTSMKEQNMSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKVLGIKTEYLLGFAEREESTKQDTIAAHLDGDFTEEELIEIRKYAELVRKAHRNQ
>NZ_CP043389.1|WP_000932219.1|1505276_1506155_-|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLNQSKIGGMPFLKYFKDIPLDENNVPMVLLAQINLDDLPEQQELFPVKEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLENIQAHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>NZ_CP043389.1|WP_000660172.1|1506156_1506270_-|hypothetical-protein
MKEKLLGTIIWSIATFYYSRMMEIMNLAILKIKIGGS
>NZ_CP043389.1|WP_000290485.1|1506333_1506714_-|glycine-cleavage-system-protein-GcvH
MAVPNELKYSKEHEWVKVEGNVAIIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQIEALLTAEKYSEMIGE
>NZ_CP043389.1|WP_000589549.1|1506871_1507228_-|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>NZ_CP043389.1|WP_001190695.1|1507371_1507692_+|thioredoxin-family-protein
MQSIKSNESFKSVINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>NZ_CP043389.1|WP_000422909.1|1507841_1508381_-|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVHVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEGDMPKAPRKNRNLITLY
>NZ_CP043389.1|WP_000150017.1|1508463_1509180_-|type-I-3-dehydroquinate-dehydratase
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGVPQAPGQIDVTDLKAQVTLY
>NZ_CP043389.1|WP_000974460.1|1509327_1509750_+|organic-hydroperoxide-resistance-protein
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDSDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>NZ_CP043389.1|WP_000569884.1|1510148_1510643_+|GNAT-family-N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>NZ_CP043389.1|WP_000255561.1|1510797_1511415_+|amino-acid-transporter
MVTAIIHGFILAIGLILPLGAQNVFIFNQGANQPKYRYVLPAIITAGLSDSLLIIIAVVGVSIIIMSLPVLQAIIYIVGLIFLMYMAWTIWHDKPSTDGETQIMSPMKQVSFALSVSLLNPHAILDTIGVIGSSAALYSGSNKIAFTIACISVSWLWFFLLAILGKMVGSIDKTGKLLTIINKISSIIIIIVALMILQKLIQLLF

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Click the colored protein region to show detailed information

Crispr_ID: NZ_CP043389_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_4

1541060-1541152

Orphan

Consensus_repeat	Method
AGTTGGGGTGGGGCCCCAACATAGTGAAATTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043389_4

>merge|NZ_CP043389|4|1541060-1541152|CRISPRCasFinder
AGTTGGGGTGGGGCCCCAACATAGTGAAATTGGCTCCTCCCAATTTCTACAGGCAATGCAAGTTGGGGTGGGGCCCCAACATAGAGAAATTGG

>NZ_CP043389|4|4|1541060-1541152|CRISPRCasFinder
AGTTGGGGTGGGGCCCCAACATAGTGAAATTGG	CTCCTCCCAATTTCTACAGGCAATGCA
AGTTGGGGTGGGGCCCCAACATAGAGAAATTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_000785252.1\|1532589_1533048_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000070826.1\|1541389_1542019_-\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NZ_CP043389.1\|WP_001248939.1\|1546080_1547076_-\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_CP043389.1\|WP_001165952.1\|1531433_1532174_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224561
NZ_CP043389.1\|WP_000006551.1\|1545026_1545971_-\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP043389.1\|WP_000134963.1\|1548863_1549799_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP043389.1\|WP_000654030.1\|1539616_1540630_-\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP043389.1\|WP_001121760.1\|1533387_1534692_-\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
NZ_CP043389.1\|WP_001050064.1\|1529027_1531400_-\|ribonuclease-R	unknown	unknown	gnl\|CDD\|273947
NZ_CP043389.1\|WP_001074749.1\|1537224_1538415_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CP043389.1\|WP_000816295.1\|1542720_1543623_+\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NZ_CP043389.1\|WP_000556760.1\|1532289_1532523_-\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|224233
NZ_CP043389.1\|WP_001049165.1\|1543865_1544453_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_CP043389.1\|WP_000279414.1\|1538553_1539564_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NZ_CP043389.1\|WP_000057551.1\|1549865_1551305_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NZ_CP043389.1\|WP_001224793.1\|1551312_1551798_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP043389.1\|WP_001085505.1\|1534821_1536339_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|235463
NZ_CP043389.1\|WP_000369722.1\|1547072_1547984_-\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NZ_CP043389.1\|WP_000513308.1\|1551805_1552645_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP043389.1\|WP_001260089.1\|1536341_1537103_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000070826.1\|1541389_1542019_-\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.85535e-05
NZ_CP043389.1\|WP_001224793.1\|1551312_1551798_-\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NZ_CP043389.1\|WP_001248939.1\|1546080_1547076_-\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NZ_CP043389.1\|WP_001165952.1\|1531433_1532174_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	9.08697e-131
NZ_CP043389.1\|WP_000006551.1\|1545026_1545971_-\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NZ_CP043389.1\|WP_000134963.1\|1548863_1549799_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NZ_CP043389.1\|WP_000654030.1\|1539616_1540630_-\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
NZ_CP043389.1\|WP_001121760.1\|1533387_1534692_-\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
NZ_CP043389.1\|WP_001050064.1\|1529027_1531400_-\|ribonuclease-R	gnl\|CDD\|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NZ_CP043389.1\|WP_001074749.1\|1537224_1538415_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP043389.1\|WP_000816295.1\|1542720_1543623_+\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	4.94096e-153
NZ_CP043389.1\|WP_000556760.1\|1532289_1532523_-\|preprotein-translocase-subunit-SecG	gnl\|CDD\|224233	COG1314, SecG, Preprotein translocase subunit SecG [Intracellular trafficking and secretion].	6.41939e-15
NZ_CP043389.1\|WP_001049165.1\|1543865_1544453_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NZ_CP043389.1\|WP_000279414.1\|1538553_1539564_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP043389.1\|WP_000057551.1\|1549865_1551305_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.28078e-06
NZ_CP043389.1\|WP_001085505.1\|1534821_1536339_-\|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase	gnl\|CDD\|235463	PRK05434, PRK05434, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase.	0
NZ_CP043389.1\|WP_000369722.1\|1547072_1547984_-\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NZ_CP043389.1\|WP_000513308.1\|1551805_1552645_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119
NZ_CP043389.1\|WP_001260089.1\|1536341_1537103_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	2.84083e-146

>NZ_CP043389.1|WP_000654030.1|1539616_1540630_-|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>NZ_CP043389.1|WP_000279414.1|1538553_1539564_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>NZ_CP043389.1|WP_001074749.1|1537224_1538415_-|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
>NZ_CP043389.1|WP_001260089.1|1536341_1537103_-|triose-phosphate-isomerase
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK
>NZ_CP043389.1|WP_001085505.1|1534821_1536339_-|2,3-bisphosphoglycerate-independent-phosphoglycerate-mutase
MAKKPTALIILDGFANRESEHGNAVKLANKPNFDRYYNKYPTTQIEASGLDVGLPEGQMGNSEVGHMNIGAGRIVYQSLTRINKSIEDGDFFENDVLNNAIAHVNSHDSALHIFGLLSDGGVHSHYKHLFALLELAKKQGVEKVYVHAFLDGRDVDQKSALKYIEETEAKFNELGIGQFASVSGRYYAMDRDKRWEREEKAYNAIRNFDAPTYATAKEGVEASYNEGLTDEFVVPFIVENQNDGVNDGDAVIFYNFRPDRAAQLSEIFANRAFEGFKVEQVKDLFYATFTKYNDNIDAAIVFEKVDLNNTIGEIAQNNNLTQLRIAETEKYPHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIILNFANPDMVGHSGMLEPTIKAIEAVDECLGEVVDKILDMDGYAIITADHGNSDQVLTDDDQPMTTHTTNPVPVIVTKEGVTLRETGRLGDLAPTLLDLLNVEQPEDMTGESLIKH
>NZ_CP043389.1|WP_001121760.1|1533387_1534692_-|phosphopyruvate-hydratase
MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYLGKGVTKAVENVNEIIAPEIIEGEFSVLDQVSIDKMMIALDGTPNKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMILPVGATTFKESLRWGTEIFHNLKSILSKRGLETAVGDEGGFAPKFEGTEDAVETIIQAIEAAGYKPGEEVFLGFDCASSEFYENGVYDYSKFEGEHGAKRTAAEQVDYLEQLVDKYPIITIEDGMDENDWDGWKQLTERIGDRVQLVGDDLFVTNTEILAKGIENGIGNSILIKVNQIGTLTETFDAIEMAQKAGYTAVVSHRSGETEDTTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKYDGIKSFYNLDK
>NZ_CP043389.1|WP_000785252.1|1532589_1533048_-|hypothetical-protein
MADRTNKEIKTGRFIATASIVFSILLIIHYFVSLDNATAKALLNLTNQNTSDKAIDYILNSFRFTGIMYILAYLAGFITFWNRHTYVWWFMFAVYVSNSLFTLINLSITIQAIKAAHGAYLTLPILIVIIGSVALAIYMLVVSIKRKSTFNR
>NZ_CP043389.1|WP_000556760.1|1532289_1532523_-|preprotein-translocase-subunit-SecG
MHTFLIVLLIIDCIALITVVLLQEGKSSGLSGAISGGAEQLFGKQKQRGVDLFLNRLTIILSILFFVLMICISYLGM
>NZ_CP043389.1|WP_001165952.1|1531433_1532174_-|alpha/beta-fold-hydrolase
MQIKLPKPFFFEEGKRAVLLLHGFTGNSSDVRQLGRFLQKKGYTSYAPQYEGHAAPPDEILKSSPFVWFKDALDGYDYLVEQGYDEIVVAGLSLGGDFALKLSLNRDVKGIVTMCAPMGGKTEGAIYEGFLEYARNFKKYEGKDQETIDNEMDHFKPTETLKELSEALDTIKEQVDEVLDPILVIQAENDNMIDPQSANYIYDHVDSDDKNIKWYSESGHVITIDKEKEQVFEDIYQFLESLDWSE
>NZ_CP043389.1|WP_001050064.1|1529027_1531400_-|ribonuclease-R
MNLKQSIEEIINQPEYEPMSVSDFQDALGLSSADSFRDLIKVLVELEQSGLIERTKTDRYQKKHSYRGQSKLIKGTLSQNKKGFAFLRPEDEDMEDIFIPPTKINRALDGDTVIVEIHQSKGEHKGKIEGEVKSIEKHSVTQVVGTYSEARHFGFVIPDDKRIMQDIFIPKGQSLGAVDGHKVLVQITKYADGSDNPEGHISAILGHKNDPGVDILSIIYQHGIEIEFPDEVLQEAEAVPDHIENTEIKGRHDLRDELTITIDGADAKDLDDAISVKKLANGNTQLTVSIADVSYYVTEGSALDKEAYDRATSVYLVDRVIPMIPHRLSNGICSLNPNVDRLTLSCRMEIDASGRVVKHEIFDSVIHSDYRMTYDAVNQIITEKDPNIREQYNEITPMLDLAQDLSNRLIQMRKRRGEIDFDISEAKVLVNEDGIPTDVQLRQRGEGERLIESFMLIANETVAEHFSKLDVPFIYRVHEQPKSDRLRQFFDFITNFGIMIKGTGEDIHPTTLQKVQEEVEGRPEQMVISTMMLRSMQQAHYDDVNLGHFGLSAEYYTHFTSPIRRYPDLTVHRLIRKYLIEKSMDNKEVKRWEDKLPELAEHTSKRERRAIEAERDTDELKKAEYMIQHIGDEFEGIVSSVANFGMFIELPNTIEGMVHIANMTDDYYRFEERQMALIGERQAKVFRIGDTVKVKVTHVDVDERLIDFQIVGMPLPKNDRSQRPARGKTIQAKTRGKSLDKSKSDDKGRKKKGKQRKGKNQRNNDKSGNSKHKPFYKDKSVKKKARRKKK
>NZ_CP043389.1|WP_000070826.1|1541389_1542019_-|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>NZ_CP043389.1|WP_000816295.1|1542720_1543623_+|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKALFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGIILSNEGGALQTMKLPYEYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>NZ_CP043389.1|WP_001049165.1|1543865_1544453_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NZ_CP043389.1|WP_000006551.1|1545026_1545971_-|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NZ_CP043389.1|WP_001248939.1|1546080_1547076_-|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NZ_CP043389.1|WP_000369722.1|1547072_1547984_-|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NZ_CP043389.1|WP_000134963.1|1548863_1549799_-|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NZ_CP043389.1|WP_000057551.1|1549865_1551305_-|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDMEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP043389.1|WP_001224793.1|1551312_1551798_-|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP043389.1|WP_000513308.1|1551805_1552645_-|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK

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Crispr_ID: NZ_CP043389_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_5

1548417-1548502

Unclear

Consensus_repeat	Method
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043389_5

>merge|NZ_CP043389|5|1548417-1548502|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGGCGGGGCCCCAACACAGAAGCTGGCGGAAAGTCAGCTTACAATAATGTGCAAGTTGG

>NZ_CP043389|5|5|1548417-1548502|CRISPRCasFinder
AAAGTCAGCTTACAATAATGTGCAAGTTGG	CGGGGCCCCAACACAGAAGCTGGCGG
AAAGTCAGCTTACAATAATGTGCAAGTTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_000070826.1\|1541389_1542019_-\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
NZ_CP043389.1\|WP_001224793.1\|1551312_1551798_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_CP043389.1\|WP_000958224.1\|1552650_1553583_-\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
NZ_CP043389.1\|WP_000538141.1\|1559585_1560236_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
NZ_CP043389.1\|WP_000006551.1\|1545026_1545971_-\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
NZ_CP043389.1\|WP_000134963.1\|1548863_1549799_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_CP043389.1\|WP_000749380.1\|1560409_1561249_-\|CHAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|226451
NZ_CP043389.1\|WP_000654030.1\|1539616_1540630_-\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_CP043389.1\|WP_001248939.1\|1546080_1547076_-\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_CP043389.1\|WP_000662675.1\|1554244_1557091_-\|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl\|CDD\|234734
NZ_CP043389.1\|WP_001074749.1\|1537224_1538415_-\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613
NZ_CP043389.1\|WP_000816295.1\|1542720_1543623_+\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|224015
NZ_CP043389.1\|WP_001049165.1\|1543865_1544453_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_CP043389.1\|WP_000279414.1\|1538553_1539564_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
NZ_CP043389.1\|WP_000057551.1\|1549865_1551305_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
NZ_CP043389.1\|WP_000638419.1\|1559352_1559589_-\|CsbA-family-protein	unknown	unknown	gnl\|CDD\|227234
NZ_CP043389.1\|WP_000369722.1\|1547072_1547984_-\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|224574
NZ_CP043389.1\|WP_000229253.1\|1557098_1559084_-\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
NZ_CP043389.1\|WP_000513308.1\|1551805_1552645_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
NZ_CP043389.1\|WP_001260089.1\|1536341_1537103_-\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000070826.1\|1541389_1542019_-\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.85535e-05
NZ_CP043389.1\|WP_001224793.1\|1551312_1551798_-\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
NZ_CP043389.1\|WP_000958224.1\|1552650_1553583_-\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
NZ_CP043389.1\|WP_000538141.1\|1559585_1560236_-\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
NZ_CP043389.1\|WP_000006551.1\|1545026_1545971_-\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
NZ_CP043389.1\|WP_000134963.1\|1548863_1549799_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
NZ_CP043389.1\|WP_000749380.1\|1560409_1561249_-\|CHAP-domain-containing-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	2.23913e-42
NZ_CP043389.1\|WP_000654030.1\|1539616_1540630_-\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
NZ_CP043389.1\|WP_001248939.1\|1546080_1547076_-\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
NZ_CP043389.1\|WP_000662675.1\|1554244_1557091_-\|excinuclease-ABC-subunit-UvrA	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_CP043389.1\|WP_001074749.1\|1537224_1538415_-\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NZ_CP043389.1\|WP_000816295.1\|1542720_1543623_+\|TIGR01777-family-protein	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	4.94096e-153
NZ_CP043389.1\|WP_001049165.1\|1543865_1544453_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
NZ_CP043389.1\|WP_000279414.1\|1538553_1539564_-\|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP043389.1\|WP_000057551.1\|1549865_1551305_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.28078e-06
NZ_CP043389.1\|WP_000638419.1\|1559352_1559589_-\|CsbA-family-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
NZ_CP043389.1\|WP_000369722.1\|1547072_1547984_-\|RNase-adapter-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
NZ_CP043389.1\|WP_000229253.1\|1557098_1559084_-\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
NZ_CP043389.1\|WP_000513308.1\|1551805_1552645_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.39921e-119
NZ_CP043389.1\|WP_001260089.1\|1536341_1537103_-\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	2.84083e-146

>NZ_CP043389.1|WP_000369722.1|1547072_1547984_-|RNase-adapter-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>NZ_CP043389.1|WP_001248939.1|1546080_1547076_-|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>NZ_CP043389.1|WP_000006551.1|1545026_1545971_-|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>NZ_CP043389.1|WP_001049165.1|1543865_1544453_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>NZ_CP043389.1|WP_000816295.1|1542720_1543623_+|TIGR01777-family-protein
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKALFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGIILSNEGGALQTMKLPYEYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>NZ_CP043389.1|WP_000070826.1|1541389_1542019_-|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDKASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>NZ_CP043389.1|WP_000654030.1|1539616_1540630_-|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>NZ_CP043389.1|WP_000279414.1|1538553_1539564_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>NZ_CP043389.1|WP_001074749.1|1537224_1538415_-|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
>NZ_CP043389.1|WP_001260089.1|1536341_1537103_-|triose-phosphate-isomerase
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK
>NZ_CP043389.1|WP_000134963.1|1548863_1549799_-|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>NZ_CP043389.1|WP_000057551.1|1549865_1551305_-|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDMEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYHNELFVSENDVMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>NZ_CP043389.1|WP_001224793.1|1551312_1551798_-|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>NZ_CP043389.1|WP_000513308.1|1551805_1552645_-|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGSVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>NZ_CP043389.1|WP_000958224.1|1552650_1553583_-|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>NZ_CP043389.1|WP_000662675.1|1554244_1557091_-|excinuclease-ABC-subunit-UvrA
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEHDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIEVPEYRRPASDRKISIRGARSNNLKGVDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>NZ_CP043389.1|WP_000229253.1|1557098_1559084_-|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVEGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>NZ_CP043389.1|WP_000638419.1|1559352_1559589_-|CsbA-family-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>NZ_CP043389.1|WP_000538141.1|1559585_1560236_-|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>NZ_CP043389.1|WP_000749380.1|1560409_1561249_-|CHAP-domain-containing-protein
MKKSLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVTKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP043389_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_6

1724220-1724312

Orphan

Consensus_repeat	Method
TAGCATCCAACTGCGTTCCTCTTCATCTTTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043389_6

>merge|NZ_CP043389|6|1724220-1724312|CRISPRCasFinder
TAGCATCCAACTGCGTTCCTCTTCATCTTTAGCGATTAGAGGCTTTTATGCAGTTGTGCCTTAGCATCCAACTGCGTTCCTCTTCACCTTTAG

>NZ_CP043389|6|6|1724220-1724312|CRISPRCasFinder
TAGCATCCAACTGCGTTCCTCTTCATCTTTAG	CGATTAGAGGCTTTTATGCAGTTGTGCCT
TAGCATCCAACTGCGTTCCTCTTCACCTTTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_000735558.1\|1719965_1720472_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000477504.1\|1731294_1731771_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP043389.1\|WP_000362967.1\|1720607_1721408_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP043389.1\|WP_000655099.1\|1727719_1727827_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000633782.1\|1731939_1732476_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP043389.1\|WP_001813976.1\|1723263_1724091_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238563
NZ_CP043389.1\|WP_001200748.1\|1727901_1728912_-\|alcohol-dehydrogenase-AdhP	unknown	unknown	gnl\|CDD\|181842
NZ_CP043389.1\|WP_001790232.1\|1722165_1723116_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
NZ_CP043389.1\|WP_001045421.1\|1718130_1718919_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP043389.1\|WP_001021145.1\|1725552_1727214_-\|arginine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234964
NZ_CP043389.1\|WP_077442703.1\|1715253_1715790_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP043389.1\|WP_000746375.1\|1714769_1715273_+\|transposase	unknown	unknown	gnl\|CDD\|225382
NZ_CP043389.1\|WP_001222133.1\|1719087_1719804_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000808902.1\|1732686_1733625_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381309
NZ_CP043389.1\|WP_001819741.1\|1727210_1727594_-\|DUF1934-family-protein	unknown	unknown	gnl\|CDD\|226896
NZ_CP043389.1\|WP_000365354.1\|1721391_1722111_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
NZ_CP043389.1\|WP_001788287.1\|1729410_1729932_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378039
NZ_CP043389.1\|WP_000901764.1\|1724529_1725165_-\|endonuclease-III-domain-containing-protein	unknown	unknown	gnl\|CDD\|225140
NZ_CP043389.1\|WP_000180230.1\|1729959_1731255_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224004
NZ_CP043389.1\|WP_001018677.1\|1717505_1717880_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|130944

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000362967.1\|1720607_1721408_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.17592e-26
NZ_CP043389.1\|WP_000633782.1\|1731939_1732476_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	3.16348e-26
NZ_CP043389.1\|WP_001813976.1\|1723263_1724091_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238563	cd01143, YvrC, Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains.	1.32108e-72
NZ_CP043389.1\|WP_001200748.1\|1727901_1728912_-\|alcohol-dehydrogenase-AdhP	gnl\|CDD\|181842	PRK09422, PRK09422, ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional.	0
NZ_CP043389.1\|WP_001790232.1\|1722165_1723116_-\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	5.19191e-48
NZ_CP043389.1\|WP_001045421.1\|1718130_1718919_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.55978e-34
NZ_CP043389.1\|WP_001021145.1\|1725552_1727214_-\|arginine--tRNA-ligase	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	0
NZ_CP043389.1\|WP_077442703.1\|1715253_1715790_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	4.55456e-53
NZ_CP043389.1\|WP_000746375.1\|1714769_1715273_+\|transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	2.373e-09
NZ_CP043389.1\|WP_000477504.1\|1731294_1731771_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.13315e-11
NZ_CP043389.1\|WP_000808902.1\|1732686_1733625_-\|aldo/keto-reductase	gnl\|CDD\|381309	cd19083, AKR_AKR11A1_11D1, AKR11A and AKR11D families of aldo-keto reductase (AKR). Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).	7.3194e-168
NZ_CP043389.1\|WP_001819741.1\|1727210_1727594_-\|DUF1934-family-protein	gnl\|CDD\|226896	COG4506, COG4506, Uncharacterized protein conserved in bacteria [Function unknown].	9.50091e-54
NZ_CP043389.1\|WP_000365354.1\|1721391_1722111_-\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	3.6864e-38
NZ_CP043389.1\|WP_001788287.1\|1729410_1729932_-\|hypothetical-protein	gnl\|CDD\|378039	pfam08741, YwhD, YwhD family. This family of proteins are currently uncharacterized. They are around 170 amino acids in length.	8.7406e-98
NZ_CP043389.1\|WP_000901764.1\|1724529_1725165_-\|endonuclease-III-domain-containing-protein	gnl\|CDD\|225140	COG2231, COG2231, Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair].	3.98158e-90
NZ_CP043389.1\|WP_000180230.1\|1729959_1731255_-\|HD-domain-containing-protein	gnl\|CDD\|224004	COG1078, COG1078, HD superfamily phosphohydrolases [General function prediction only].	1.70707e-150
NZ_CP043389.1\|WP_001018677.1\|1717505_1717880_+\|transcriptional-regulator	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	1.77309e-26

>NZ_CP043389.1|WP_001813976.1|1723263_1724091_-|ABC-transporter-substrate-binding-protein
MKDNDKQGSNDNGSSKSPYHRIVSLMPSNTEILYELGLGKYIVGVSTVDDYPKDVKKGKKQFDALNLNKEELLKAKPDLILAHESQKATANKVLSSLEKQGIKVVYVKDAQSIDETYNTFKQIGKLTHHDKQAEQLVEETKDNIDKVIDSIPAHHKKSKVFIEVSSKPEIYTAGKHTFFNDMLEKLEAQNVYSDINGWNPVTKESIIKKNPDILISTEAKTRSDYMDIIKKRGGFNKINAVKNTRIEVVNGDEVSRPGPRIDEGLKELRDAIYRK
>NZ_CP043389.1|WP_001790232.1|1722165_1723116_-|iron-ABC-transporter-permease
MTFNKVLLSWIVILIITTSIYLFWQLGDINDVFNQSILINVRLPRLLEALLTGMILTVAGLIFQTVLNNALADSFTLGLASGATFGSGLALFLGLTTLWIPVFSITFSLITLITVLVITSVLSQGYPVRILILSGLMIGALFNSLLYFLILLKPRKLNTIANYLFGGFGDAEYSNVSIIAITFIIALFGIFIILNQLKLLQLGELKSQSLGLNVQLITYIALCIASMITAINVAYVGIIGFIGMVIPQLIRKWQWKQSLGRQLALNIVTGGQIMVMADFIGSHILSPVQIPASIIIALIGIPVLFYMLISQSKRLH
>NZ_CP043389.1|WP_000365354.1|1721391_1722111_-|HAD-family-hydrolase
MDLNQIKAVVFDLEGTLLDRVKSREKFIEEQYERFHDYLIHVQLADFKKAFIELDDDEDNDKPDLYKEIIKRFHVDRLTWKDLFNDFEMHFYRYVFPYYDTLYTLEKLSQKGFQIGVIANGKSKIKQFRLHSLGLMHVINYLSTSETVGFRKPHPKIFEDMIDQLGVLPEQIMYVGDDALNDVAPARAMGMVSVWYKQEDAEIEPLEEEVDFTITTVEELLTILPIKNDNKGENYGSIY
>NZ_CP043389.1|WP_000362967.1|1720607_1721408_-|alpha/beta-hydrolase
MDLFTRKDGTSIHYSTLGEGYPIVLIHTVLDNYSVFNKLAAELAKSFQVVLIDLRGHGYSDKPRHIEIKDFSDDIVELLKYLYIEEVAFVCHEMGGIIGADISVRYPEFTSSLTLVNPTSIEGELPEERLFRKYAHIIRNWDPEKQDKFLNKRKYYRPRKMNRFLKHVVDTNEISTKEEIQAVKEVFKNADISQTYRNVVVPTKIIAGEFGERTTRLEAKEVADLIQNADFEVYQESSAFPFVEEQERFVEDTAAFINKHHDEKHV
>NZ_CP043389.1|WP_000735558.1|1719965_1720472_-|hypothetical-protein
MKKLLTASIIACSVVMGVGLVNTSAEAASGNSIDTVKQLIKGDQSLENVKIGESIKDVLTKYKNPMYSYNEDGTEHYYEFHTKKGMLLVTTDGKKNNGKVTHISMMYNDANGPTYQAVKNYVGKAVTHTEYSKVAGNFGYIEKGKTTYQFASAPKDKNIKLYRIDLEK
>NZ_CP043389.1|WP_001222133.1|1719087_1719804_-|hypothetical-protein
MRINDKILLENIEDYFNHKGLSPHLIDDIKEKVITDIKNSEKKDQDYIEYKRKSPAQIILMIQRNLFALQMNPVIFFIINFILISYLYDKQYVQFQAITGMSLFYCLVIFPMTIVVYLRVSQKNYLRSNKIEMIMGTIIAIISLLLIILQAFNITWGVIPITNFGHQFFFFIGIILVIAGIFYKRLEFSGIGLLFCQKTVDAMIHNPQSAQIFSLIIWILLVVLVIYFTIRLSSRTRL
>NZ_CP043389.1|WP_001045421.1|1718130_1718919_-|alpha/beta-hydrolase
MNKVTINPQIQLTYQIEGKGDPIILLHGLDGNLAGFEDLQHQLASSYKVLTYDLRGHGKSSKSESYDLNDHVEDLKILMEKLNIHEAHILGHDLGGVVAKLFTDKYAYRVKSLTTIASKKDDLIHSFTQLLIQYQDDIAGFNKSEAYILLFSKLFRNQEKTMKWYQKQRIYSIKSEDDSAVAIRSLILHKDEPMYLKKRTCVPTLLINGEHDPLIKDKNHFKLEAHFLNVTKKIFEHSGHAPHIEEPEAFMNYYLKFLKSVS
>NZ_CP043389.1|WP_001018677.1|1717505_1717880_+|transcriptional-regulator
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
>NZ_CP043389.1|WP_077442703.1|1715253_1715790_+|IS30-family-transposase
MGSKSINNREEFGHYEIDTVWSVRPSTYCLLTIIERKTRYLYASRLNTRKSNVVCNEIINIMKPLLPKSITMDRGKEFALFEEIEDELNCSIYFSDLGCPYQRGSIENANGLLRQYYPKGTDFANITQKSLDEAVKQINARPRMIFDYKSSEEMLKYHVSTQNCEPILNDCVRHEPVN
>NZ_CP043389.1|WP_000746375.1|1714769_1715273_+|transposase
MKKRKKRKELDYKTRLAIAKYLNDGLNIIQISKILGRDDAVLYREVNKRSVDGVYNPLLAEEDAIKSRSISDEQVAKRRRLNDETKAYIEEKLSLKWSPRQIASQIEKDTGYYISYPTIYRYIRNGLVKVDVKRDMRQAGKKYNKSSEKRGKLDVGSRVIKYRLKKY
>NZ_CP043389.1|WP_000901764.1|1724529_1725165_-|endonuclease-III-domain-containing-protein
MLGTDELYKVLYEHLGPQFWWPADNDIEMMLGAILVQNTRWRNAEIALNQIKEHTHFNPNHILELPIETLQSLIHSSGFYKSKSLTIKTLLTWLARHHFNYQEINERYKGGLRKELLSLKGIGSETADVLLVYIFGRIEFIPDSYTRKIYDKLGYENTKNYDQLKKVVTLPNHFTNQDANEFHALLDVFGKHYFRDKDIKNYDFLEPYFKK
>NZ_CP043389.1|WP_001021145.1|1725552_1727214_-|arginine--tRNA-ligase
MNIIDQVKQTLVEEIAASINKAGLADEIPDIKIEVPKDTKNGDYATNIAMVLTKIAKRNPREIAQAIVDNLDTEKAHVKQIDIAGPGFINFYLDNQYLTAIIPEAIEKGDQFGHVNESKGQNVLLEYVSANPTGDLHIGHARNAAVGDALANILTAAGYNVTREYYINDAGNQITNLARSIETRFFEALGDNSYSMPEDGYNGKDIIEIGKDLAEKHPEIKDYSEEARLKEFRKLGVEYEMAKLKNDLAEFNTHFDNWFSETSLYEKGEILEVLAKMKELGYTYEADGATWLRTTDFKDDKDRVLIKNDGTYTYFLPDIAYHFDKVKRGNDILIDLFGADHHGYINRLKASLETFGVDSNRLEIQIMQMVRLMENGKEVKMSKRTGNAITLREIMDEVGVDAARYFLTMRSPDSHFDFDMELAKEQSQDNPVYYAQYAHARICSILKQAKEQGIEVTAANDFTTITNEKAIELLKKVADFEPTIESAAEHRSAHRITNYIQDLASHFHKFYNAEKVLTDDIEKTKAHVAMIEAVRITLKNALAMVGVSAPESM
>NZ_CP043389.1|WP_001819741.1|1727210_1727594_-|DUF1934-family-protein
MLKQHNEKEKFEFTTEGTWQQRQSNFIRYVEQIEDATVNVTIKVDDDSVKLIRKGDINMNLHFVEGQTTTTFYDISAGRIPLEVKTLRILHFVSGDGGKLKIHYELYQDNEKMGSYQYEINYKEIGE
>NZ_CP043389.1|WP_000655099.1|1727719_1727827_-|hypothetical-protein
MKDSENLVFFGFEVLFVFYKMAYIYEALIKYGIVN
>NZ_CP043389.1|WP_001200748.1|1727901_1728912_-|alcohol-dehydrogenase-AdhP
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVAKTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
>NZ_CP043389.1|WP_001788287.1|1729410_1729932_-|hypothetical-protein
MEVISLSEKKGFNFNIIKNDPLDGHKGTNIGSISLDNIAPVFIDVANKEAFIDIGGMHARAKVEKGVKWITDKAAVEGDEAKEYWLCWVTTERNEQGPYYAGLTACYLLVNKAIRRGYKSMPEHVNMMDKSMKHHIIIDQIGDENKAILKDFLMNHDEGMWKHSSDALHQAFN
>NZ_CP043389.1|WP_000180230.1|1729959_1731255_-|HD-domain-containing-protein
MTNAYVDLKLVEEKVFKDPIHRYIHVEDQLIWDLIKTKEFQRLRRIRQLGTLYLSFHTAEHSRFGHSLGVYEIVRRLIDESFIGHDAWDNKDRPLALCAALLHDLGHGPFSHSFEKIFNTDHEAYTQAIITGDTEVNAVLRKVAPEFPREVAEVINKTHHNKLVISMISSQIDADRMDYLQRDAYFTGVSYGAFDMERILRLMRPSKDEVLIKESGMHAVENFIMSRYQMYWQIYFHPVSRGGEVLLNNCLKRAKQLYNEGYEFKLHPHDFIPFFEETVTIEQYVELDEAVVTYYLEKWTKEDDAILSDLASRFINRDLFKYIPFDGSIITISELQELFEAGGINPDYYFVSEAFSDLPYDYDRPGSNRKPIHLLRQDGTIREISNQSLVIHSITGINRQDYKLYYPREMVAKIKDKTIREAIENLINELN
>NZ_CP043389.1|WP_000477504.1|1731294_1731771_-|GNAT-family-N-acetyltransferase
MFKVRQATEKDVVQIRDVATKAWFNTYLNIYAATTVNHLLEASYNEHHLKKRLQEQLFLVVEEGNDIVGFANFIYGEELYLSAHYVKPESQHTGYGTALLNEGLSRFEDKFEGVYLEVDNKNEEAVAYYKEQGFTILRSYEPEMYGEKLDLALMYKAF
>NZ_CP043389.1|WP_000633782.1|1731939_1732476_-|flavodoxin-family-protein
MITVLFGGSRPNGNTAQLTKFALQDLEYQWIDVTQHQFKPIRDVRHTAETITSYDDDYLPILDKILASDTIIFASPVYWYSISAPLKAFIEHWSETLQDKRYPNFKAQMAEKDFRVILVGGDCPKIKAKPAITQMKYSLDFLGATLNGYIIGTAEKPGDIMKDNYALARATEWNSILQ
>NZ_CP043389.1|WP_000808902.1|1732686_1733625_-|aldo/keto-reductase
MKQFVNLGKSDVEVFPIALGTNAVGGHNLYPNLDEEQGKDVVRQAINHGINLLDTAYIYGPERSEELVGEVVKEYPREQIKIATKGSHEFDENQEVHQNNQPEYLKQQVENSLKRLQTDYIDLYYIHFPDNNTPKDQAVAALQELKEQGKIKAIGVSNFTLDQLKEANKDGYVDVVQLEYNLLHRENEAVLQYCVDHQITFIPYFPLASGILAGKYDENTKFSDHRTTRRDFKPGVFEENVRRVKALESIAAAHQTSIANIVLAFYLTRPAIDVIIPGAKRAEQVVENIKAADIVLSDDEIQYIDELFPIED

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP043389_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_7

2035776-2035854

Orphan

Consensus_repeat	Method
TGTTGGGGCCCCGCCAACCTGCA	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of NZ_CP043389_7

>merge|NZ_CP043389|7|2035776-2035854|CRISPRCasFinder
TGTTGGGGCCCCGCCAACCTGCACATTATCGTAAGCTGACTTTTCGTCAGCTTCTGTGTTGGGGCCCCGCCAACCTGCA

>NZ_CP043389|7|7|2035776-2035854|CRISPRCasFinder
TGTTGGGGCCCCGCCAACCTGCA	CATTATCGTAAGCTGACTTTTCGTCAGCTTCTG
TGTTGGGGCCCCGCCAACCTGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_001790679.1\|2041154_2041247_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000037075.1\|2030523_2031741_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
NZ_CP043389.1\|WP_001795438.1\|2027893_2029150_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|376723
NZ_CP043389.1\|WP_000180461.1\|2029152_2029353_-\|DUF1128-family-protein	unknown	unknown	gnl\|CDD\|227177
NZ_CP043389.1\|WP_000999713.1\|2036120_2037107_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
NZ_CP043389.1\|WP_001549145.1\|2037596_2038010_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000613733.1\|2041461_2042016_+\|3'-5'-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
NZ_CP043389.1\|WP_001803060.1\|2037117_2037315_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000140176.1\|2042083_2043154_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
NZ_CP043389.1\|WP_001110179.1\|2034231_2034618_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000149064.1\|2033515_2034217_-\|cell-wall-active-antibiotics-response-protein	unknown	unknown	gnl\|CDD\|227100
NZ_CP043389.1\|WP_000636142.1\|2034834_2035593_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_CP043389.1\|WP_001017131.1\|2032475_2033519_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP043389.1\|WP_000949467.1\|2040572_2041073_+\|H-type-ferritin-FtnA	unknown	unknown	gnl\|CDD\|224445
NZ_CP043389.1\|WP_001790257.1\|2038038_2038149_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_001250336.1\|2038967_2040281_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_CP043389.1\|WP_000544969.1\|2038234_2038966_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
NZ_CP043389.1\|WP_000153530.1\|2031856_2032486_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP043389.1\|WP_000428172.1\|2029970_2030246_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000228666.1\|2029499_2029964_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000037075.1\|2030523_2031741_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	4.24482e-85
NZ_CP043389.1\|WP_001795438.1\|2027893_2029150_-\|aminopeptidase	gnl\|CDD\|376723	pfam02073, Peptidase_M29, Thermophilic metalloprotease (M29).	0
NZ_CP043389.1\|WP_000180461.1\|2029152_2029353_-\|DUF1128-family-protein	gnl\|CDD\|227177	COG4840, COG4840, Uncharacterized protein conserved in bacteria [Function unknown].	2.44511e-24
NZ_CP043389.1\|WP_000999713.1\|2036120_2037107_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	6.20478e-76
NZ_CP043389.1\|WP_000613733.1\|2041461_2042016_+\|3'-5'-exonuclease	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	1.92778e-75
NZ_CP043389.1\|WP_000149064.1\|2033515_2034217_-\|cell-wall-active-antibiotics-response-protein	gnl\|CDD\|227100	COG4758, COG4758, Predicted membrane protein [Function unknown].	9.42019e-79
NZ_CP043389.1\|WP_000636142.1\|2034834_2035593_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.9498e-126
NZ_CP043389.1\|WP_001017131.1\|2032475_2033519_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.78722e-72
NZ_CP043389.1\|WP_000949467.1\|2040572_2041073_+\|H-type-ferritin-FtnA	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	4.6035e-74
NZ_CP043389.1\|WP_001250336.1\|2038967_2040281_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	7.18737e-99
NZ_CP043389.1\|WP_000544969.1\|2038234_2038966_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	3.33663e-121
NZ_CP043389.1\|WP_000153530.1\|2031856_2032486_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.91794e-79
NZ_CP043389.1\|WP_000140176.1\|2042083_2043154_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
NZ_CP043389.1\|WP_000228666.1\|2029499_2029964_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	3.39151e-65

>NZ_CP043389.1|WP_000636142.1|2034834_2035593_-|type-I-methionyl-aminopeptidase
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
>NZ_CP043389.1|WP_001110179.1|2034231_2034618_-|hypothetical-protein
MNYVERYIEQFLRATVRNNIKHYLLMLDEKMKNLDDYMRYLITKKEQLSKLIDSLMLTLENKYIDIAEAFQIQCAREINNQEIENIKSELNKVEAYYAQIETQIQQTSTEKIATEKTSYLINYMNAVA
>NZ_CP043389.1|WP_000149064.1|2033515_2034217_-|cell-wall-active-antibiotics-response-protein
MTHKYISTQMLIIFTALMIIANFYYIFFEKIGFLLVLLLGCVLVYVGYLYFHKIRGLLAFWIGALLIAFTLLSNKYTIIILFVFLLLLIVRYLIHKFKPKKVVATDEVMTSPSFIKQKWFGEQRTPVYVYKWEDVQIQHGIGDLHIDLTKAANIKENNTIVVRHILGKVQVILPVNYNINLHVAAFYGSTYVNEKSYKVENNNIHIEEMMKPDNYTVNIYVSTFIGDVEVIYR
>NZ_CP043389.1|WP_001017131.1|2032475_2033519_-|sensor-histidine-kinase
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
>NZ_CP043389.1|WP_000153530.1|2031856_2032486_-|response-regulator-transcription-factor
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
>NZ_CP043389.1|WP_000037075.1|2030523_2031741_+|YihY/virulence-factor-BrkB-family-protein
MSKKDHSSSKYLNSVKEAQEESKKKNKSNPKIDVDRTYIEPQQFQSKKPKKDDQVFFLSRLNKPAKYKKDSNFLSYLIYRIGKDDASGLAAQMTYHFVLAMFPMLLFLLTLLPFFNIKQSQITNMLSNAPAETSTLIKSVIGDITQNSSGGLLSIGLILAIWSASNGMTAIMNSFNVAYDVEDSRNGIVLKLLSVVFTVVMGVVFVVALALPTLGSVISHFLFGPLGFDEQVKWIFNLIRIVLPIIIIFIIFIVLYSVAPNVKTKLKSVLPGAVFTSIIWLAGSFGFGWYISNFGNYSKTYGSIAGIIILLLWLYITSFIIIVGAEINAIIHQRSVIKGKTPEEAALEHDDNNKNHYNENTRYEYDEDSNATHQRTYHVDEHPSDTYPEDDKNIKDKIVDKLKKD
>NZ_CP043389.1|WP_000428172.1|2029970_2030246_+|hypothetical-protein
MENKFVPGILIGAVIGGAISLADKSTRQALVQSVKDAKNGNRTRKPSKVSKIKDEVLYWKDVVEEIRRNNPELERSLKDAKETFVNRKNQR
>NZ_CP043389.1|WP_000228666.1|2029499_2029964_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
>NZ_CP043389.1|WP_000180461.1|2029152_2029353_-|DUF1128-family-protein
MTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHE
>NZ_CP043389.1|WP_001795438.1|2027893_2029150_-|aminopeptidase
MGILTNYKEKLQQYAELLVKVGMNVQPKQPVFIRSSVETLELTHLIVEEAYHCGASDVRVVYSDPTLKRLKFENESVEHFANHEIKSYDVEARMDYVKRGAANLALISEDPDLMDGIDSQKLQAFQQQNARAFKGYMESVQKNQFPWVVAAFPSKAWAKRVYPELSVEEAYIKFIDEVFDIVRIDGNDPVENWRQHIANLSVYAQKLQQKNYHALHYVSEGTDLTVGLAKNHIWEDATSYVNGKEQAFIANIPTEEVFTAPDRNRVDGYVTNKLPLSYNGTIIDQFKLMFKDGEIIDFSAGKGEAVLKDLINTDEGSRRLGEVALVPDDSPISNRNTIFYNTLFDENAACHLAIGSAYAFNIQGGTEMTVEEKIASGLNDSNVHVDFMIGSSDLTIYGIFEDGSKELVFENGNWASTF
>NZ_CP043389.1|WP_000999713.1|2036120_2037107_+|aromatic-acid-exporter-family-protein
MNDQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQELILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHILYEVLMIYRLLDSRYA
>NZ_CP043389.1|WP_001803060.1|2037117_2037315_-|hypothetical-protein
MQVGVWAPTKRNWIPNFYRQCKLGCGPQHREFRKEILQAKRVGVGRRNKFYENIISVPLPWCQLA
>NZ_CP043389.1|WP_001549145.1|2037596_2038010_-|hypothetical-protein
MKPTKVILKDASYLHSKTSITFILKDVVIEEDNKIYYFDTSATFEDQEVKFEFALFDSDMDNLKHMDCDNPVTEIYFIEPDLHFTIIDFNQELLCIYIDFDSGLRHSNMATESGISLRINVAKSDFTKFINELASLH
>NZ_CP043389.1|WP_001790257.1|2038038_2038149_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>NZ_CP043389.1|WP_000544969.1|2038234_2038966_-|type-1-glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIVIESDTFGTIVGFENHGGRTYHDFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEIQAKQVLIDRANRQKKSR
>NZ_CP043389.1|WP_001250336.1|2038967_2040281_-|Mur-ligase-family-protein
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNADDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISSFDVAPFLYLNINDEKYDMKIAGDFNAYNALAAYTVLRELGLNEQTIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>NZ_CP043389.1|WP_000949467.1|2040572_2041073_+|H-type-ferritin-FtnA
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEESMFETHINYLTRIGDDSNALYLYEKELGARTFDEE
>NZ_CP043389.1|WP_001790679.1|2041154_2041247_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>NZ_CP043389.1|WP_000613733.1|2041461_2042016_+|3'-5'-exonuclease
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKIHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>NZ_CP043389.1|WP_000140176.1|2042083_2043154_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVHSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEQTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYQNVHDILMTLDIGDFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI

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Crispr_ID: NZ_CP043389_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_8

2270727-2270877

Orphan

Consensus_repeat	Method
AACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

2 spacers

csa3

The CRISPR arrays of NZ_CP043389_8

>merge|NZ_CP043389|8|2270727-2270877|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTAAACTTTAGTTGTTAGGGGCTCTTATGCAGTTGATGCGTAGCATCCAACTGTGTTCCTCTATTTTTCAACTTTAGTTGTTAGGGGCTTCTTTCTA

>NZ_CP043389|8|8|2270727-2270877|CRISPRCasFinder
AACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTACTTTTA
AACTTTAGTTGTTAGGGGCTCTTATGCA	GTTGATGCGTAGCATCCAACTGTGTTCCTCTATTTTTC
AACTTTAGTTGTTAGGGGCTTCTTTCTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_000334465.1\|2276160_2277966_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP043389.1\|WP_001127960.1\|2265859_2266798_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
NZ_CP043389.1\|WP_000083807.1\|2278646_2280185_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
NZ_CP043389.1\|WP_001123303.1\|2262682_2263096_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
NZ_CP043389.1\|WP_001802298.1\|2271208_2271313_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000070866.1\|2262039_2262483_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
NZ_CP043389.1\|WP_001790138.1\|2273424_2273517_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000495671.1\|2269617_2270709_+\|lytic-regulatory-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000003759.1\|2268049_2268370_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
NZ_CP043389.1\|WP_001024094.1\|2267232_2267898_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
NZ_CP043389.1\|WP_000808817.1\|2265598_2265829_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000927360.1\|2280219_2282352_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_CP043389.1\|WP_001292149.1\|2282363_2282798_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|227014
NZ_CP043389.1\|WP_000019744.1\|2268371_2269352_+\|CDF-family-zinc-efflux-transporter-CzrB	unknown	unknown	gnl\|CDD\|224151
NZ_CP043389.1\|WP_000115564.1\|2271999_2273136_-\|SAP-domain-containing-protein	unknown	unknown	gnl\|CDD\|366887
NZ_CP043389.1\|WP_000908176.1\|2275146_2275929_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP043389.1\|WP_000370924.1\|2274221_2275079_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
NZ_CP043389.1\|WP_000648718.1\|2282797_2283904_+\|mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
NZ_CP043389.1\|WP_000160304.1\|2261208_2261919_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_CP043389.1\|WP_000123393.1\|2263553_2264927_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000123393.1\|2263553_2264927_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
NZ_CP043389.1\|WP_001127960.1\|2265859_2266798_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
NZ_CP043389.1\|WP_000070866.1\|2262039_2262483_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
NZ_CP043389.1\|WP_001292149.1\|2282363_2282798_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
NZ_CP043389.1\|WP_000334465.1\|2276160_2277966_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP043389.1\|WP_000003759.1\|2268049_2268370_+\|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17
NZ_CP043389.1\|WP_001024094.1\|2267232_2267898_-\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	5.74381e-48
NZ_CP043389.1\|WP_000370924.1\|2274221_2275079_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	5.39747e-59
NZ_CP043389.1\|WP_000927360.1\|2280219_2282352_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	9.74009e-67
NZ_CP043389.1\|WP_000019744.1\|2268371_2269352_+\|CDF-family-zinc-efflux-transporter-CzrB	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.049e-108
NZ_CP043389.1\|WP_000115564.1\|2271999_2273136_-\|SAP-domain-containing-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	3.91533e-06
NZ_CP043389.1\|WP_000908176.1\|2275146_2275929_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	4.88024e-103
NZ_CP043389.1\|WP_000083807.1\|2278646_2280185_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
NZ_CP043389.1\|WP_000648718.1\|2282797_2283904_+\|mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
NZ_CP043389.1\|WP_000160304.1\|2261208_2261919_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
NZ_CP043389.1\|WP_001123303.1\|2262682_2263096_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	3.14887e-46

>NZ_CP043389.1|WP_000495671.1|2269617_2270709_+|lytic-regulatory-protein
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYAQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>NZ_CP043389.1|WP_000019744.1|2268371_2269352_+|CDF-family-zinc-efflux-transporter-CzrB
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>NZ_CP043389.1|WP_000003759.1|2268049_2268370_+|Zn(II)-responsive-metalloregulatory-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>NZ_CP043389.1|WP_001024094.1|2267232_2267898_-|SDR-family-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGDQDIKDALTQFENETD
>NZ_CP043389.1|WP_001127960.1|2265859_2266798_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>NZ_CP043389.1|WP_000808817.1|2265598_2265829_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>NZ_CP043389.1|WP_000123393.1|2263553_2264927_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRISNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>NZ_CP043389.1|WP_001123303.1|2262682_2263096_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>NZ_CP043389.1|WP_000070866.1|2262039_2262483_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>NZ_CP043389.1|WP_000160304.1|2261208_2261919_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>NZ_CP043389.1|WP_001802298.1|2271208_2271313_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>NZ_CP043389.1|WP_000115564.1|2271999_2273136_-|SAP-domain-containing-protein
MSVNARDLLVLHTNVNRLVGEEIFANKCLANNDVQIMNSIKKLIEAELLTTTNDFEVSIYKKTRPELQSILKSFGIKTTGNKPDLIKRIDDNFHIINNLDLPYVYIPTKKGEEILKKTEYLTSFIQSYGEISLERAYYLVENYIDENCDDKVAEIYKFEFQRKYDNGEFDFNHGYNFELNMLIDHYKRDVKDYDNARKYSNIYLYFGLRDFLKKLMSNYSYYDSKGNIDLNEIQNDLNRFINSSASGMYERLIYNENLSNNIMFELFKKDTQDYSDLEEQLIEKFINYVVSNVKKESRSNTLIELSKILENGYTIDKEEFKKEDDYLSKYIFTDIDYLKKLESKINVAIDIRSGEIHLVLDDDSLDILIQNQKYGNEF
>NZ_CP043389.1|WP_001790138.1|2273424_2273517_+|hypothetical-protein
MFIFKTTSKSHFHNNVKSLECIKIPINKNR
>NZ_CP043389.1|WP_000370924.1|2274221_2275079_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAEHFLAE
>NZ_CP043389.1|WP_000908176.1|2275146_2275929_-|ABC-transporter-ATP-binding-protein
MLIQLDQIGRMKQGKTILKKISWQIAKGDKWILYGLNGAGKTTLLNILNAYEPATSGTVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMFAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITANFSKILLLKDGQSIQQGAVEDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>NZ_CP043389.1|WP_000334465.1|2276160_2277966_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>NZ_CP043389.1|WP_000083807.1|2278646_2280185_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>NZ_CP043389.1|WP_000927360.1|2280219_2282352_+|BglG-family-transcription-antiterminator
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGTDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLDQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDVDGNTSFENEQTSYLTSVFEKHLSDEKSEQLLHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFISDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>NZ_CP043389.1|WP_001292149.1|2282363_2282798_+|PTS-sugar-transporter-subunit-IIA
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>NZ_CP043389.1|WP_000648718.1|2282797_2283904_+|mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKATVLDAVEDSSIEAGLRRVLAETSQYITNEFDFTEAEQAAYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKAFLSEYAKVDDGLADEIIEAYNSLS

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Crispr_ID: NZ_CP043389_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043389_9

2394644-2394837

Orphan

Consensus_repeat	Method
TGTTGGGGCCCCGCCAACTTGCA	CRT

3 spacers

The CRISPR arrays of NZ_CP043389_9

>merge|NZ_CP043389|9|2394644-2394837|CRT
TGTTGGGGCCCCGCCAACTTGCACATTATTGTATGCTGACTTTTCGTCACCTTCTGTGTTGGGGCCCCGTTCCCCAACTTGCATTGTCTGTAGAATTTCTTTTTGAAATTCTCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTCTGTCAGCTTCTGTGTTGGGGCCCCGCCAACTTGTA

>NZ_CP043389|9|2|2394644-2394837|CRT
TGTTGGGGCCCCGCCAACTTGCA	CATTATTGTATGCTGACTTTTCGTCACCTTCTG
TGTTGGGGCCCCGTTCCCCAACT	TGCATTGTCTGTAGAATTTCTTTTTGAAATTCTCTA
TGTTGGGGCCCCGCCAACTTGCA	CATTATTGTAAGCTGACTTTCTGTCAGCTTCTG
TGTTGGGGCCCCGCCAACTTGTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043389.1\|WP_000643988.1\|2396020_2396620_-\|molybdenum-cofactor-guanylyltransferase-MobA	unknown	unknown	gnl\|CDD\|234725
NZ_CP043389.1\|WP_000259718.1\|2397807_2399067_-\|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
NZ_CP043389.1\|WP_000230173.1\|2394978_2396001_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|274250
NZ_CP043389.1\|WP_000503817.1\|2399625_2400132_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	unknown	unknown	gnl\|CDD\|223595
NZ_CP043389.1\|WP_000866971.1\|2396626_2396860_-\|molybdopterin-converting-factor-subunit-1	unknown	unknown	gnl\|CDD\|340452
NZ_CP043389.1\|WP_000051206.1\|2385171_2385336_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000066900.1\|2393937_2394288_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
NZ_CP043389.1\|WP_000413865.1\|2389368_2390634_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
NZ_CP043389.1\|WP_000600967.1\|2391265_2392030_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
NZ_CP043389.1\|WP_000592303.1\|2386084_2389252_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP043389.1\|WP_000808500.1\|2396865_2397312_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	unknown	unknown	gnl\|CDD\|223391
NZ_CP043389.1\|WP_000913019.1\|2401336_2401942_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|226628
NZ_CP043389.1\|WP_000951059.1\|2392191_2392632_+\|winged-helix-DNA-binding-protein	unknown	unknown	gnl\|CDD\|197670
NZ_CP043389.1\|WP_001549681.1\|2391022_2391274_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000134528.1\|2399129_2399624_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
NZ_CP043389.1\|WP_000076929.1\|2400162_2401167_-\|molybdopterin-biosynthesis-protein-MoeB	unknown	unknown	gnl\|CDD\|181084
NZ_CP043389.1\|WP_000602937.1\|2397325_2397811_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
NZ_CP043389.1\|WP_001790034.1\|2394413_2394584_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_001161085.1\|2385580_2385898_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043389.1\|WP_000184419.1\|2392624_2393836_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042

Protein	Function_ID	Function_description	E-value
NZ_CP043389.1\|WP_000643988.1\|2396020_2396620_-\|molybdenum-cofactor-guanylyltransferase-MobA	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	5.68918e-67
NZ_CP043389.1\|WP_000134528.1\|2399129_2399624_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	3.63862e-98
NZ_CP043389.1\|WP_000230173.1\|2394978_2396001_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
NZ_CP043389.1\|WP_000503817.1\|2399625_2400132_-\|molybdenum-cofactor-biosynthesis-protein-MoaB	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	1.02752e-64
NZ_CP043389.1\|WP_000866971.1\|2396626_2396860_-\|molybdopterin-converting-factor-subunit-1	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	8.16473e-25
NZ_CP043389.1\|WP_000066900.1\|2393937_2394288_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
NZ_CP043389.1\|WP_000413865.1\|2389368_2390634_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	4.8324e-143
NZ_CP043389.1\|WP_000600967.1\|2391265_2392030_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
NZ_CP043389.1\|WP_000592303.1\|2386084_2389252_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP043389.1\|WP_000913019.1\|2401336_2401942_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	3.32197e-115
NZ_CP043389.1\|WP_000951059.1\|2392191_2392632_+\|winged-helix-DNA-binding-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.873e-15
NZ_CP043389.1\|WP_000808500.1\|2396865_2397312_-\|molybdenum-cofactor-biosynthesis-protein-MoaE	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	5.56799e-58
NZ_CP043389.1\|WP_000076929.1\|2400162_2401167_-\|molybdopterin-biosynthesis-protein-MoeB	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	3.67241e-132
NZ_CP043389.1\|WP_000602937.1\|2397325_2397811_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	4.35501e-50
NZ_CP043389.1\|WP_000259718.1\|2397807_2399067_-\|molybdopterin-molybdotransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	9.49423e-160
NZ_CP043389.1\|WP_000184419.1\|2392624_2393836_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.27961e-72

>NZ_CP043389.1|WP_001790034.1|2394413_2394584_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNGMECDINVKEPLKIYYVVILKSGIEMIFS
>NZ_CP043389.1|WP_000066900.1|2393937_2394288_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>NZ_CP043389.1|WP_000184419.1|2392624_2393836_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETNVIDKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>NZ_CP043389.1|WP_000951059.1|2392191_2392632_+|winged-helix-DNA-binding-protein
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLREAHND
>NZ_CP043389.1|WP_000600967.1|2391265_2392030_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>NZ_CP043389.1|WP_001549681.1|2391022_2391274_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLVIIHMGILAHSTYVYLY
>NZ_CP043389.1|WP_000413865.1|2389368_2390634_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>NZ_CP043389.1|WP_000592303.1|2386084_2389252_-|efflux-RND-transporter-permease-subunit
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASAPNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHADGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>NZ_CP043389.1|WP_001161085.1|2385580_2385898_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVVFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>NZ_CP043389.1|WP_000051206.1|2385171_2385336_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDIEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>NZ_CP043389.1|WP_000230173.1|2394978_2396001_-|GTP-3',8-cyclase-MoaA
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>NZ_CP043389.1|WP_000643988.1|2396020_2396620_-|molybdenum-cofactor-guanylyltransferase-MobA
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>NZ_CP043389.1|WP_000866971.1|2396626_2396860_-|molybdopterin-converting-factor-subunit-1
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>NZ_CP043389.1|WP_000808500.1|2396865_2397312_-|molybdenum-cofactor-biosynthesis-protein-MoaE
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>NZ_CP043389.1|WP_000602937.1|2397325_2397811_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRHIVSFLKSHGYTVATIKHHGHGKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRNEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>NZ_CP043389.1|WP_000259718.1|2397807_2399067_-|molybdopterin-molybdotransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFVDGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>NZ_CP043389.1|WP_000134528.1|2399129_2399624_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTLIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSNQ
>NZ_CP043389.1|WP_000503817.1|2399625_2400132_-|molybdenum-cofactor-biosynthesis-protein-MoaB
MGEHQNVKLNRTVKAAVLTVSDTRDFDTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIDGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>NZ_CP043389.1|WP_000076929.1|2400162_2401167_-|molybdopterin-biosynthesis-protein-MoeB
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDDYIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKYRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSDCTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>NZ_CP043389.1|WP_000913019.1|2401336_2401942_-|ATP-binding-cassette-domain-containing-protein
MLKINVKYQLKNTLIRINIDDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTAKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSEHIDQLIQTLNIDHLMKQYPMTLSGGEAQRVALARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP043389_3	3.1\|1505116\|34\|NZ_CP043389\|CRISPRCasFinder	1505116-1505149	34	NZ_CP043389.1	926964-926997	0	1.0
NZ_CP043389_3	3.1\|1505116\|34\|NZ_CP043389\|CRISPRCasFinder	1505116-1505149	34	NZ_CP043389.1	1016156-1016189	0	1.0
NZ_CP043389_9	9.2\|2394723\|36\|NZ_CP043389\|CRT	2394723-2394758	36	NZ_CP043389.1	1224380-1224415	0	1.0
NZ_CP043389_2	2.2\|1442193\|26\|NZ_CP043389\|CRT	1442193-1442218	26	NZ_CP043389.1	1548391-1548416	1	0.962
NZ_CP043389_5	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	NZ_CP043389.1	1585510-1585535	1	0.962
NZ_CP043389_5	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	NZ_CP043389.1	2835954-2835979	1	0.962
NZ_CP043389_5	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	NZ_CP043389.1	2836010-2836035	1	0.962
NZ_CP043389_7	7.1\|2035799\|33\|NZ_CP043389\|CRISPRCasFinder	2035799-2035831	33	NZ_CP043389.1	1016202-1016234	1	0.97
NZ_CP043389_7	7.1\|2035799\|33\|NZ_CP043389\|CRISPRCasFinder	2035799-2035831	33	NZ_CP043389.1	1224327-1224359	1	0.97
NZ_CP043389_7	7.1\|2035799\|33\|NZ_CP043389\|CRISPRCasFinder	2035799-2035831	33	NZ_CP043389.1	2670604-2670636	1	0.97
NZ_CP043389_7	7.1\|2035799\|33\|NZ_CP043389\|CRISPRCasFinder	2035799-2035831	33	NZ_CP043389.1	701686-701718	1	0.97
NZ_CP043389_7	7.1\|2035799\|33\|NZ_CP043389\|CRISPRCasFinder	2035799-2035831	33	NZ_CP043389.1	1548404-1548436	1	0.97
NZ_CP043389_9	9.2\|2394723\|36\|NZ_CP043389\|CRT	2394723-2394758	36	NZ_CP043389.1	523230-523265	1	0.972
NZ_CP043389_2	2.2\|1442193\|26\|NZ_CP043389\|CRT	1442193-1442218	26	NZ_CP043389.1	395110-395135	2	0.923
NZ_CP043389_2	2.4\|1442307\|26\|NZ_CP043389\|CRT	1442307-1442332	26	NZ_CP043389.1	1585510-1585535	2	0.923
NZ_CP043389_2	2.4\|1442307\|26\|NZ_CP043389\|CRT	1442307-1442332	26	NZ_CP043389.1	2835954-2835979	2	0.923
NZ_CP043389_2	2.4\|1442307\|26\|NZ_CP043389\|CRT	1442307-1442332	26	NZ_CP043389.1	2836010-2836035	2	0.923
NZ_CP043389_2	2.5\|1442333\|33\|NZ_CP043389\|CRISPRCasFinder	1442333-1442365	33	NZ_CP043389.1	1504812-1504844	2	0.939
NZ_CP043389_5	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	NZ_CP043389.1	1585454-1585479	2	0.923
NZ_CP043389_7	7.1\|2035799\|33\|NZ_CP043389\|CRISPRCasFinder	2035799-2035831	33	NZ_CP043389.1	926919-926951	2	0.939
NZ_CP043389_9	9.1\|2394667\|33\|NZ_CP043389\|CRT	2394667-2394699	33	NZ_CP043389.1	1016202-1016234	2	0.939
NZ_CP043389_9	9.1\|2394667\|33\|NZ_CP043389\|CRT	2394667-2394699	33	NZ_CP043389.1	1224327-1224359	2	0.939
NZ_CP043389_9	9.1\|2394667\|33\|NZ_CP043389\|CRT	2394667-2394699	33	NZ_CP043389.1	2670604-2670636	2	0.939
NZ_CP043389_9	9.1\|2394667\|33\|NZ_CP043389\|CRT	2394667-2394699	33	NZ_CP043389.1	926919-926951	2	0.939
NZ_CP043389_9	9.1\|2394667\|33\|NZ_CP043389\|CRT	2394667-2394699	33	NZ_CP043389.1	1548404-1548436	2	0.939
NZ_CP043389_9	9.2\|2394723\|36\|NZ_CP043389\|CRT	2394723-2394758	36	NZ_CP043389.1	701744-701779	2	0.944
NZ_CP043389_9	9.2\|2394723\|36\|NZ_CP043389\|CRT	2394723-2394758	36	NZ_CP043389.1	2046602-2046637	2	0.944
NZ_CP043389_9	9.3\|2394782\|33\|NZ_CP043389\|CRT	2394782-2394814	33	NZ_CP043389.1	1016202-1016234	2	0.939
NZ_CP043389_9	9.3\|2394782\|33\|NZ_CP043389\|CRT	2394782-2394814	33	NZ_CP043389.1	1224327-1224359	2	0.939
NZ_CP043389_9	9.3\|2394782\|33\|NZ_CP043389\|CRT	2394782-2394814	33	NZ_CP043389.1	2670604-2670636	2	0.939
NZ_CP043389_9	9.3\|2394782\|33\|NZ_CP043389\|CRT	2394782-2394814	33	NZ_CP043389.1	1548404-1548436	2	0.939

1. spacer 3.1|1505116|34|NZ_CP043389|CRISPRCasFinder matches to position: 926964-926997, mismatch: 0, identity: 1.0

atgggccccaacaaagagaaattggattcccaat	CRISPR spacer
atgggccccaacaaagagaaattggattcccaat	Protospacer
**********************************

2. spacer 3.1|1505116|34|NZ_CP043389|CRISPRCasFinder matches to position: 1016156-1016189, mismatch: 0, identity: 1.0

atgggccccaacaaagagaaattggattcccaat	CRISPR spacer
atgggccccaacaaagagaaattggattcccaat	Protospacer
**********************************

3. spacer 9.2|2394723|36|NZ_CP043389|CRT matches to position: 1224380-1224415, mismatch: 0, identity: 1.0

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttctttttgaaattctcta	Protospacer
************************************

4. spacer 2.2|1442193|26|NZ_CP043389|CRT matches to position: 1548391-1548416, mismatch: 1, identity: 0.962

tcgccagcttctgtgttggggccccg	CRISPR spacer
tcgtcagcttctgtgttggggccccg	Protospacer
***.**********************

5. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to position: 1585510-1585535, mismatch: 1, identity: 0.962

cggggccccaacacagaagctggcgg	CRISPR spacer
cggggccccaacacagaagcaggcgg	Protospacer
******************** *****

6. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to position: 2835954-2835979, mismatch: 1, identity: 0.962

cggggccccaacacagaagctggcgg	CRISPR spacer
cggggccccaacatagaagctggcgg	Protospacer
*************.************

7. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to position: 2836010-2836035, mismatch: 1, identity: 0.962

cggggccccaacacagaagctggcgg	CRISPR spacer
cggggccccaacaaagaagctggcgg	Protospacer
************* ************

8. spacer 7.1|2035799|33|NZ_CP043389|CRISPRCasFinder matches to position: 1016202-1016234, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
******.**************************

9. spacer 7.1|2035799|33|NZ_CP043389|CRISPRCasFinder matches to position: 1224327-1224359, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
******.**************************

10. spacer 7.1|2035799|33|NZ_CP043389|CRISPRCasFinder matches to position: 2670604-2670636, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
******.**************************

11. spacer 7.1|2035799|33|NZ_CP043389|CRISPRCasFinder matches to position: 701686-701718, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattatagtaagctgacttttcgtcagcttctg	Protospacer
****** **************************

12. spacer 7.1|2035799|33|NZ_CP043389|CRISPRCasFinder matches to position: 1548404-1548436, mismatch: 1, identity: 0.97

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
******.**************************

13. spacer 9.2|2394723|36|NZ_CP043389|CRT matches to position: 523230-523265, mismatch: 1, identity: 0.972

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttcttttcgaaattctcta	Protospacer
************************.***********

14. spacer 2.2|1442193|26|NZ_CP043389|CRT matches to position: 395110-395135, mismatch: 2, identity: 0.923

tcgccagcttctgtgttggggccccg	CRISPR spacer
tcgtcagcttctttgttggggccccg	Protospacer
***.******** *************

15. spacer 2.4|1442307|26|NZ_CP043389|CRT matches to position: 1585510-1585535, mismatch: 2, identity: 0.923

ccgccagcctctgtgttggggccccg	CRISPR spacer
ccgcctgcttctgtgttggggccccg	Protospacer
***** **.*****************

16. spacer 2.4|1442307|26|NZ_CP043389|CRT matches to position: 2835954-2835979, mismatch: 2, identity: 0.923

ccgccagcctctgtgttggggccccg	CRISPR spacer
ccgccagcttctatgttggggccccg	Protospacer
********.***.*************

17. spacer 2.4|1442307|26|NZ_CP043389|CRT matches to position: 2836010-2836035, mismatch: 2, identity: 0.923

ccgccagcctctgtgttggggccccg	CRISPR spacer
ccgccagcttctttgttggggccccg	Protospacer
********.*** *************

18. spacer 2.5|1442333|33|NZ_CP043389|CRISPRCasFinder matches to position: 1504812-1504844, mismatch: 2, identity: 0.939

ccaacttgcacactattgtaagctgactttcca	CRISPR spacer
ccaacttgcacattattgtaagctgacttacca	Protospacer
************.**************** ***

19. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to position: 1585454-1585479, mismatch: 2, identity: 0.923

cggggccccaacacagaagctggcgg	CRISPR spacer
cggggccccaacatagaagcaggcgg	Protospacer
*************.****** *****

20. spacer 7.1|2035799|33|NZ_CP043389|CRISPRCasFinder matches to position: 926919-926951, mismatch: 2, identity: 0.939

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcatcttctg	Protospacer
******.******************* ******

21. spacer 9.1|2394667|33|NZ_CP043389|CRT matches to position: 1016202-1016234, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

22. spacer 9.1|2394667|33|NZ_CP043389|CRT matches to position: 1224327-1224359, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

23. spacer 9.1|2394667|33|NZ_CP043389|CRT matches to position: 2670604-2670636, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

24. spacer 9.1|2394667|33|NZ_CP043389|CRT matches to position: 926919-926951, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcatcttctg	Protospacer
********** ***************.******

25. spacer 9.1|2394667|33|NZ_CP043389|CRT matches to position: 1548404-1548436, mismatch: 2, identity: 0.939

cattattgtatgctgacttttcgtcaccttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********** *************** ******

26. spacer 9.2|2394723|36|NZ_CP043389|CRT matches to position: 701744-701779, mismatch: 2, identity: 0.944

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgcctgtagaatttcttttcgaaattctcta	Protospacer
*******.****************.***********

27. spacer 9.2|2394723|36|NZ_CP043389|CRT matches to position: 2046602-2046637, mismatch: 2, identity: 0.944

tgcattgtctgtagaatttctttttgaaattctcta	CRISPR spacer
tgcattgtctgtagaatttcctttcgaaattctcta	Protospacer
********************.***.***********

28. spacer 9.3|2394782|33|NZ_CP043389|CRT matches to position: 1016202-1016234, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

29. spacer 9.3|2394782|33|NZ_CP043389|CRT matches to position: 1224327-1224359, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

30. spacer 9.3|2394782|33|NZ_CP043389|CRT matches to position: 2670604-2670636, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

31. spacer 9.3|2394782|33|NZ_CP043389|CRT matches to position: 1548404-1548436, mismatch: 2, identity: 0.939

cattattgtaagctgactttctgtcagcttctg	CRISPR spacer
cattattgtaagctgacttttcgtcagcttctg	Protospacer
********************..***********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP043389_2	2.1\|1442110\|53\|NZ_CP043389\|CRT	1442110-1442162	53	MG543995	Staphylococcus phage UPMK_1, partial genome	76246-76298	4	0.925
NZ_CP043389_2	2.2\|1442193\|26\|NZ_CP043389\|CRT	1442193-1442218	26	NZ_CP022541	Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence	333735-333760	5	0.808
NZ_CP043389_5	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	NZ_CP022541	Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence	333735-333760	5	0.808
NZ_CP043389_5	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	NZ_CP034332	Tabrizicola piscis strain K13M18 plasmid unnamed4, complete sequence	3359-3384	5	0.808
NZ_CP043389_5	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	NZ_CP022605	Ochrobactrum quorumnocens strain A44 plasmid unnamed1, complete sequence	715511-715536	5	0.808
NZ_CP043389_7	7.1\|2035799\|33\|NZ_CP043389\|CRISPRCasFinder	2035799-2035831	33	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159745-159777	10	0.697

1. spacer 2.1|1442110|53|NZ_CP043389|CRT matches to MG543995 (Staphylococcus phage UPMK_1, partial genome) position: , mismatch: 4, identity: 0.925

ttgggagtgggacagaaatgatattttcgcaaaatttatttcgtcgtcccacc	CRISPR spacer
aagggagtgggacagaaatgatagtttctcaaaatttatttcgtcgtcccacc	Protospacer
  ********************* **** ************************

2. spacer 2.2|1442193|26|NZ_CP043389|CRT matches to NZ_CP022541 (Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence) position: , mismatch: 5, identity: 0.808

tcgccagcttctgtgttggggccccg	CRISPR spacer
acgccagcttctgtgttgaggcctta	Protospacer
 *****************.****...

3. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to NZ_CP022541 (Antarctobacter heliothermus strain SMS3 plasmid pSMS3-1, complete sequence) position: , mismatch: 5, identity: 0.808

cggggccccaacacagaagctggcgg	CRISPR spacer
taaggcctcaacacagaagctggcgt	Protospacer
...****.*****************

4. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to NZ_CP034332 (Tabrizicola piscis strain K13M18 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.808

cggggccccaacacagaagctggcgg	CRISPR spacer
gtaggcccagacacagaagctggcgg	Protospacer
  .***** .****************

5. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to NZ_CP022605 (Ochrobactrum quorumnocens strain A44 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.808

cggggccccaacacagaagctggcgg	CRISPR spacer
tcagggccaaacacagaagctggcgg	Protospacer
. .** ** *****************

6. spacer 7.1|2035799|33|NZ_CP043389|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 10, identity: 0.697

cattatcgtaagctgacttttcgtcagcttctg	CRISPR spacer
ttttatcgtaaggtgagttttcgtcaagcacct	Protospacer
. ********** *** *********. . *.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

461314 : 502312

Staphylococcus_phage(94.12%)

protease,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000831218.1\|461314_465427_+	SMEK domain-containing protein	A0A2H4PQT3	Staphylococcus_phage	0.0e+00	100.0
WP_002868972.1\|465965_466325_+	DUF1433 domain-containing protein	NA	NA	NA	NA
WP_001791893.1\|466672_466774_-	hypothetical protein	NA	NA	NA	NA
WP_001801861.1\|466896_466992_-	type I toxin-antitoxin system Fst family toxin PepA1	NA	NA	NA	NA
WP_001549059.1\|467194_467338_+\|transposase	transposase	A0A2H4PQU1	Staphylococcus_phage	6.4e-20	100.0
WP_001790863.1\|467540_467750_+\|transposase	transposase	A0A2H4PQV6	Staphylococcus_phage	1.4e-31	100.0
WP_000070811.1\|467941_468325_+	hypothetical protein	NA	NA	NA	NA
WP_000375476.1\|468335_468512_+	hypothetical protein	NA	NA	NA	NA
WP_000809857.1\|468513_468699_+	hypothetical protein	NA	NA	NA	NA
WP_000494956.1\|468812_469454_+	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	2.6e-76	93.2
WP_000414205.1\|469671_470223_-	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	1.0e-20	94.1
WP_000627551.1\|470320_470665_-	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	6.3e-53	92.0
WP_000188802.1\|470705_471176_-	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	7.0e-63	80.1
WP_000070653.1\|471407_472403_-	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	7.1e-73	96.4
WP_001795535.1\|472483_473134_-	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	2.7e-44	88.4
WP_011443643.1\|473436_473892_+	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.0e-79	98.6
WP_000348360.1\|474050_475529_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.0e-281	97.0
WP_000778523.1\|475533_476535_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	4.8e-186	97.6
WP_000718107.1\|476531_476789_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
WP_000672014.1\|476854_477328_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	4.7e-83	98.1
WP_002868962.1\|477332_478079_+	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	7.1e-142	98.4
WP_000109906.1\|479074_480667_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
WP_000933822.1\|481037_482231_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
WP_000366154.1\|482355_483264_+	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.2e-136	98.7
WP_000453320.1\|483475_484309_+	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	9.6e-156	98.6
WP_000623471.1\|486391_486745_-	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	99.1
WP_001200541.1\|486741_487107_-	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	1.4e-58	99.2
WP_000091445.1\|487362_487665_-	hypothetical protein	NA	NA	NA	NA
WP_001096459.1\|487924_488638_+	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
WP_001168904.1\|489077_489713_-\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
WP_001030465.1\|490008_490452_+	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	3.0e-55	85.0
WP_001153742.1\|490438_490882_-	competence protein ComK	NA	NA	NA	NA
WP_000671052.1\|490994_491465_-	RNA polymerase sigma factor	A0A2H4PQT5	Staphylococcus_phage	1.0e-82	99.4
WP_000384171.1\|491663_491888_+	hypothetical protein	NA	NA	NA	NA
WP_001032833.1\|492163_493018_+	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
WP_000163235.1\|493312_493708_-	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	6.3e-73	100.0
WP_000989121.1\|493725_495018_-	arsenite efflux transporter membrane subunit ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
WP_000221179.1\|495017_495332_-	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	2.0e-53	100.0
WP_001261677.1\|495854_497357_+	FAD-dependent oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	2.3e-30	100.0
WP_000384181.1\|497849_498881_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.8e-197	99.4
WP_000493892.1\|498887_499520_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
WP_001159022.1\|499530_500712_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
WP_001008551.1\|500724_501189_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
WP_001196354.1\|501310_502312_-	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7

DBSCAN-SWA_2

505472 : 518201

Staphylococcus_phage(100.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000764419.1\|505472_506036_-	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
WP_000526539.1\|506032_506986_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
WP_001025061.1\|507095_508277_+	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
WP_001108732.1\|508567_510982_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.2
WP_000836465.1\|511003_511315_+	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	1.6e-52	100.0
WP_105988629.1\|511640_518201_+	LPXTG-anchored repetitive surface protein SasC	A0A2H4PQU6	Staphylococcus_phage	2.0e-304	98.1

DBSCAN-SWA_3

643663 : 652706

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001005767.1\|643663_644668_+	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1
WP_001019172.1\|644669_645695_+\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_001112045.1\|645717_646857_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
WP_001160682.1\|646875_647136_+	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
WP_000749795.1\|647410_649690_+	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
WP_000594993.1\|649892_652166_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	1.2e-62	28.8
WP_000364542.1\|652187_652706_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5

DBSCAN-SWA_4

721843 : 730155

Caulobacter_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001217261.1\|721843_723643_+	DNA primase	A0A0K1LMQ9	Caulobacter_phage	4.6e-54	36.0
WP_001283055.1\|723866_724973_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
WP_000624584.1\|725103_725781_+\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
WP_000683931.1\|725783_726884_+	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	5.2e-08	29.6
WP_001062180.1\|726997_728344_+	DEAD/DEAH box helicase	A0A1V0SIR5	Klosneuvirus	5.3e-55	33.7
WP_000924214.1\|728353_729244_+	deoxyribonuclease IV	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
WP_001213908.1\|729369_730155_+	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3

DBSCAN-SWA_5

785986 : 873224

107

Staphylococcus_phage(84.42%)

portal,integrase,head,tail,terminase,plate,protease,capsid,holin,tRNA

attL 790949:790969|attR 836842:836862

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000987769.1\|785986_787738_+	HAMP domain-containing protein	A0A1V0SGX0	Hokovirus	1.7e-21	33.6
WP_001548912.1\|787982_788912_+	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001033767.1\|788904_789750_+	hypothetical protein	NA	NA	NA	NA
WP_001548909.1\|789776_790931_+	hypothetical protein	B5WZK7	Staphylococcus_phage	3.9e-115	97.7
790949:790969	attL	NA	NA	NA	NA
WP_000264751.1\|790973_792179_-\|integrase	site-specific integrase	A0A2I6PEN0	Staphylococcus_phage	7.7e-223	100.0
WP_000191466.1\|792304_792919_+	hypothetical protein	A0A2I6PEZ0	Staphylococcus_phage	6.7e-106	100.0
WP_001795334.1\|792915_793062_-	hypothetical protein	A0A2I6PEK8	Staphylococcus_phage	1.2e-16	100.0
WP_000449655.1\|793151_793547_-	hypothetical protein	A0A2I6PEJ7	Staphylococcus_phage	3.8e-70	100.0
WP_000755722.1\|793575_794010_-	hypothetical protein	A0A2I6PEM0	Staphylococcus_phage	3.6e-21	96.5
WP_000525001.1\|794027_794489_-	hypothetical protein	A0A2I6PEK4	Staphylococcus_phage	2.9e-85	98.7
WP_000429766.1\|794501_794831_-	helix-turn-helix transcriptional regulator	A0A2I6PEN2	Staphylococcus_phage	3.2e-54	100.0
WP_001115060.1\|794991_795183_+	helix-turn-helix transcriptional regulator	A0A2I6PEL6	Staphylococcus_phage	2.3e-28	100.0
WP_001548903.1\|795439_795679_-	hypothetical protein	A0A2I6PE22	Staphylococcus_phage	6.7e-38	100.0
WP_001036299.1\|795725_795941_+	hypothetical protein	A0A2I6PEK7	Staphylococcus_phage	1.0e-32	100.0
WP_001124198.1\|795965_796229_+	helix-turn-helix domain-containing protein	A0A2I6PEL8	Staphylococcus_phage	2.5e-46	100.0
WP_000829612.1\|796494_796812_+	hypothetical protein	A0A2I6PEL3	Staphylococcus_phage	1.1e-35	100.0
WP_000163431.1\|796804_797107_+	DUF2482 family protein	A0A1X9IGX2	Staphylococcus_phage	2.4e-48	100.0
WP_000291481.1\|797111_797372_+	DUF1108 family protein	A0A2I6PEM2	Staphylococcus_phage	3.4e-43	100.0
WP_000985979.1\|797385_797748_+	hypothetical protein	A0A2I6PEM7	Staphylococcus_phage	3.7e-56	100.0
WP_000762552.1\|797744_798911_+	DUF2800 domain-containing protein	A0A2I6PEL9	Staphylococcus_phage	1.4e-221	100.0
WP_000645048.1\|798936_799494_+	DUF2815 family protein	A0A2I6PEP8	Staphylococcus_phage	1.8e-97	100.0
WP_001801657.1\|799561_801514_+	DNA polymerase	A0A2I6PEL4	Staphylococcus_phage	0.0e+00	100.0
WP_001164629.1\|801526_801712_+	DUF3113 family protein	A0A2I6PEM8	Staphylococcus_phage	7.0e-27	100.0
WP_000113974.1\|801711_802113_+	PVL family protein	A0A2I6PEL5	Staphylococcus_phage	1.2e-68	100.0
WP_000022728.1\|802112_802370_+	DUF3310 domain-containing protein	A0A2I6PEN5	Staphylococcus_phage	2.6e-43	100.0
WP_000235324.1\|802372_802573_+	hypothetical protein	A0A2I6PEM3	Staphylococcus_phage	2.5e-30	100.0
WP_000132194.1\|802587_802830_+	hypothetical protein	A0A2I6PEV3	Staphylococcus_phage	1.5e-40	100.0
WP_001065039.1\|802844_803093_+	DUF1024 family protein	A0A2I6PEP2	Staphylococcus_phage	1.4e-38	100.0
WP_000185671.1\|803085_803622_+	hypothetical protein	A0A2I6PEN6	Staphylococcus_phage	1.6e-95	100.0
WP_000195794.1\|803658_803865_+	DUF1381 domain-containing protein	A0A2I6PEM9	Staphylococcus_phage	1.6e-19	100.0
WP_000141180.1\|803861_804065_+	hypothetical protein	A0A2I6PEQ8	Staphylococcus_phage	3.4e-30	100.0
WP_000608275.1\|804057_804294_+	hypothetical protein	A0A2I6PEM4	Staphylococcus_phage	2.8e-36	100.0
WP_000592202.1\|804286_804673_+	hypothetical protein	A0A1X9IGZ2	Staphylococcus_phage	3.0e-64	100.0
WP_000595263.1\|804669_804822_+	transcriptional activator RinB	A0A2I6PEM5	Staphylococcus_phage	2.0e-19	100.0
WP_000265252.1\|804889_805090_+	DUF1514 family protein	A0A2I6PEP5	Staphylococcus_phage	4.9e-26	100.0
WP_001548893.1\|805116_805323_-	hypothetical protein	A0A1X9IGZ9	Staphylococcus_phage	7.6e-30	100.0
WP_000884870.1\|805377_807825_+	hypothetical protein	A0A2I6PEP4	Staphylococcus_phage	0.0e+00	100.0
WP_001801650.1\|807933_808032_-	hypothetical protein	A0A2I6PDP6	Staphylococcus_phage	3.7e-11	100.0
WP_001548892.1\|808165_808456_+	VRR-NUC domain-containing protein	A0A2I6PE31	Staphylococcus_phage	6.5e-51	100.0
WP_001801648.1\|808436_809804_+	DEAD/DEAH box helicase	A0A2I6PE95	Staphylococcus_phage	3.0e-263	99.8
WP_000528512.1\|809816_810254_+	transcriptional regulator	A0A2I6PEN3	Staphylococcus_phage	7.9e-77	100.0
WP_000160686.1\|810410_810725_+	HNH endonuclease	A0A2I6PEN4	Staphylococcus_phage	5.0e-57	100.0
WP_000778933.1\|810851_811157_+\|terminase	terminase	A0A2I6PEQ6	Staphylococcus_phage	2.9e-49	100.0
WP_000153540.1\|811146_812838_+\|terminase	terminase large subunit	A0A1X9IGU0	Staphylococcus_phage	0.0e+00	100.0
WP_001100664.1\|812842_814081_+\|portal	phage portal protein	A0A2I6PER5	Staphylococcus_phage	6.9e-235	100.0
WP_000061866.1\|814064_814838_+\|protease	Clp protease ClpP	A0A2I6PEQ7	Staphylococcus_phage	2.4e-137	100.0
WP_001142734.1\|814849_816013_+\|capsid	phage major capsid protein	A0A2I6PEQ3	Staphylococcus_phage	1.2e-217	100.0
WP_000050973.1\|816081_816360_+\|head,tail	phage gp6-like head-tail connector protein	A0A2I6PEQ1	Staphylococcus_phage	2.1e-46	100.0
WP_000395498.1\|816371_816704_+	hypothetical protein	A0A2I6PES3	Staphylococcus_phage	4.1e-57	100.0
WP_000110023.1\|816700_817102_+	hypothetical protein	A0A2I6PF54	Staphylococcus_phage	8.1e-68	100.0
WP_001023806.1\|817102_817498_+	DUF3168 domain-containing protein	A0A2I6PEQ4	Staphylococcus_phage	8.8e-67	100.0
WP_000807536.1\|817532_818174_+\|tail	tail protein	A0A2I6PEP6	Staphylococcus_phage	5.9e-121	100.0
WP_000169127.1\|818265_818721_+	Ig domain-containing protein	A0A2I6PER6	Staphylococcus_phage	5.7e-78	100.0
WP_000589167.1\|818778_819129_+	hypothetical protein	A0A2I6PEQ2	Staphylococcus_phage	1.1e-55	100.0
WP_000438833.1\|819170_819329_+	hypothetical protein	A0A2I6PES8	Staphylococcus_phage	1.2e-19	100.0
WP_001003408.1\|819342_825543_+\|tail	phage tail tape measure protein	A0A1X9IGU9	Staphylococcus_phage	0.0e+00	99.7
WP_001190533.1\|825542_826367_+\|tail	phage tail family protein	A0A2I6PER3	Staphylococcus_phage	4.1e-159	100.0
WP_000384474.1\|826375_827959_+	peptidase	A0A2I6PEQ5	Staphylococcus_phage	9.3e-309	100.0
WP_000179858.1\|827958_828249_+	hypothetical protein	U5U457	Staphylococcus_phage	2.1e-49	100.0
WP_000429558.1\|828264_830175_+	minor structural protein	A0A2I6PEQ9	Staphylococcus_phage	0.0e+00	100.0
WP_000067127.1\|830174_831641_+\|plate	BppU family phage baseplate upper protein	A0A2I6PES7	Staphylococcus_phage	1.5e-273	100.0
WP_001166599.1\|831640_832030_+	DUF2977 domain-containing protein	A0A2I6PER1	Staphylococcus_phage	2.2e-62	100.0
WP_000916020.1\|832022_832187_+	XkdX family protein	A0A2I6PES4	Staphylococcus_phage	4.9e-24	100.0
WP_000466784.1\|832232_832532_+	DUF2951 domain-containing protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
WP_000339146.1\|832667_832970_+\|holin	phage holin	A0A2I6PET6	Staphylococcus_phage	7.0e-48	100.0
WP_000909220.1\|832980_834435_+	CHAP domain-containing protein	A0A2I6PET7	Staphylococcus_phage	5.7e-289	100.0
WP_000239545.1\|834824_835763_+	Panton-Valentine bi-component leukocidin subunit S	A0A2I6PER8	Staphylococcus_phage	3.7e-180	100.0
WP_024937002.1\|835758_836742_+	Panton-Valentine bi-component leukocidin subunit F	A0A2I6PEU3	Staphylococcus_phage	4.0e-185	100.0
WP_061390271.1\|836924_837176_+	hypothetical protein	A0ZS61	Staphylococcus_virus	2.4e-25	100.0
836842:836862	attR	NA	NA	NA	NA
WP_000476873.1\|837266_838184_+	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_000472936.1\|838240_839179_+	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001033757.1\|839171_839378_+	hypothetical protein	NA	NA	NA	NA
WP_000913219.1\|839392_840307_+	DUF1672 domain-containing protein	NA	NA	NA	NA
WP_001789947.1\|840505_840625_+	hypothetical protein	NA	NA	NA	NA
WP_001186912.1\|840903_841449_+	ECF transporter S component	NA	NA	NA	NA
WP_001151997.1\|841554_841803_-	ferredoxin	A0A127AYY7	Bacillus_phage	8.3e-15	48.0
WP_001163801.1\|841910_842864_+	hypothetical protein	NA	NA	NA	NA
WP_000902119.1\|842853_844233_+	ATP-dependent DNA helicase RecQ	L7RCS0	Acanthamoeba_polyphaga_moumouvirus	2.9e-56	33.6
WP_000069282.1\|844385_845846_+	elastin-binding protein EbpS	NA	NA	NA	NA
WP_001789943.1\|845970_846087_+	hypothetical protein	NA	NA	NA	NA
WP_001174260.1\|846247_847234_+	YpdA family putative bacillithiol disulfide reductase	NA	NA	NA	NA
WP_000681756.1\|847348_848317_-	asparaginase	NA	NA	NA	NA
WP_000644391.1\|848393_849053_+	(d)CMP kinase	NA	NA	NA	NA
WP_001789945.1\|849083_849200_+	hypothetical protein	NA	NA	NA	NA
WP_001789944.1\|849316_849508_+	hypothetical protein	NA	NA	NA	NA
WP_000133954.1\|849764_850940_+	30S ribosomal protein S1	NA	NA	NA	NA
WP_000165536.1\|851161_852472_+	ribosome biogenesis GTPase Der	NA	NA	NA	NA
WP_000161738.1\|852488_853487_+	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_001043863.1\|853657_853930_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	4.2e-28	73.3
WP_000450553.1\|854360_854933_+	heptaprenyl diphosphate synthase component 1	NA	NA	NA	NA
WP_000774684.1\|854935_855661_+	demethylmenaquinone methyltransferase	NA	NA	NA	NA
WP_001817755.1\|855677_856622_+	heptaprenyl diphosphate synthase subunit II	A0A1V0SE37	Indivirus	1.3e-10	24.4
WP_000442480.1\|856713_857163_+	nucleoside-diphosphate kinase	D2E8E1	Anguillid_herpesvirus	2.4e-28	43.8
WP_000789522.1\|857371_857572_+	hypothetical protein	NA	NA	NA	NA
WP_001269929.1\|857957_859124_+	chorismate synthase	A0A291AU41	Pandoravirus	7.6e-34	32.1
WP_000776323.1\|859149_860214_+	3-dehydroquinate synthase	NA	NA	NA	NA
WP_000245895.1\|860223_861522_+	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
WP_000389524.1\|861528_862773_+	hypothetical protein	NA	NA	NA	NA
WP_000004947.1\|862786_863362_+	IDEAL domain-containing protein	G3MAV7	Bacillus_virus	2.7e-08	27.2
WP_000152734.1\|863351_863939_+	DUF1405 domain-containing protein	NA	NA	NA	NA
WP_001827022.1\|864010_864691_+	zinc metallopeptidase	NA	NA	NA	NA
WP_000839926.1\|865027_865345_+	nucleotide pyrophosphohydrolase	NA	NA	NA	NA
WP_000690027.1\|865585_866728_+	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA	NA	NA	NA	NA
WP_000361544.1\|866732_867935_+\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	3.2e-35	42.5
WP_000049919.1\|867921_868893_+	biotin--[acetyl-CoA-carboxylase] ligase	NA	NA	NA	NA
WP_000525078.1\|868916_871610_+	ATP-dependent helicase DinG	A0A1X9I5C8	Streptococcus_phage	8.2e-47	34.4
WP_000858789.1\|871931_873224_+\|tRNA	asparagine--tRNA ligase	A0A2P1EMB4	Moumouvirus	1.9e-54	30.0

DBSCAN-SWA_6

1314992 : 1323465

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000238664.1\|1314992_1315559_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.1
WP_000030812.1\|1315561_1316590_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.3e-61	41.4
WP_000483713.1\|1316582_1318067_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.2e-45	31.7
WP_000032727.1\|1318045_1320235_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.0e-140	39.7
WP_000666799.1\|1320227_1320899_-	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
WP_000848350.1\|1320900_1321164_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000174053.1\|1321163_1321868_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
WP_001010412.1\|1321871_1322996_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_000861572.1\|1322982_1323465_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7

DBSCAN-SWA_7

1484380 : 1503610

Staphylococcus_phage(63.16%)

terminase,integrase,capsid

attL 1487102:1487118|attR 1501058:1501074

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000168845.1\|1484380_1485142_-	Fe-S cluster assembly ATPase SufC	A0A1V0SE00	Indivirus	4.4e-06	23.3
WP_001183858.1\|1485469_1486321_+	DUF368 domain-containing protein	NA	NA	NA	NA
WP_000752917.1\|1486553_1486748_-	CsbD family protein	NA	NA	NA	NA
1487102:1487118	attL	NA	NA	NA	NA
WP_001035618.1\|1487781_1488336_+	DUF4888 domain-containing protein	A0A1W6JQE5	Staphylococcus_phage	4.8e-71	76.1
WP_000801979.1\|1488570_1489539_-	Abi family protein	A0A0H4U080	Erysipelothrix_phage	5.9e-24	27.3
WP_086034110.1\|1489815_1489971_-\|terminase	terminase	A0A1W6JQF0	Staphylococcus_phage	3.1e-20	92.0
WP_000253084.1\|1489967_1490459_-	hypothetical protein	A0A2H4JB26	uncultured_Caudovirales_phage	7.9e-25	40.5
WP_000657538.1\|1490642_1491701_-\|capsid	phage capsid protein	A0A0K2CZ99	Paenibacillus_phage	3.6e-14	26.6
WP_000884055.1\|1491687_1491894_-	hypothetical protein	NA	NA	NA	NA
WP_001081424.1\|1492118_1492463_-	hypothetical protein	A0A1W6JQD5	Staphylococcus_phage	9.4e-41	65.2
WP_000985235.1\|1493133_1495506_-	primase	A0A2H4JCU9	uncultured_Caudovirales_phage	9.8e-137	39.3
WP_001103959.1\|1495597_1495846_-	DUF1474 family protein	Q4ZE75	Staphylococcus_phage	1.4e-22	58.6
WP_000403840.1\|1495846_1496230_-	hypothetical protein	A0A1W6JQI7	Staphylococcus_phage	4.4e-63	96.9
WP_001231376.1\|1496231_1496435_-	hypothetical protein	A0A1W6JQF4	Staphylococcus_phage	2.0e-30	98.5
WP_000784892.1\|1496401_1496575_-	hypothetical protein	NA	NA	NA	NA
WP_000091732.1\|1496586_1496859_-	winged helix-turn-helix domain-containing protein	Q4ZE77	Staphylococcus_phage	4.8e-40	88.9
WP_000243849.1\|1496851_1497115_-	helix-turn-helix transcriptional regulator	A0A2H4J9X2	uncultured_Caudovirales_phage	4.1e-36	94.8
WP_001260004.1\|1497307_1497640_+	helix-turn-helix transcriptional regulator	A0A1J0MFC1	Staphylococcus_phage	1.6e-37	74.5
WP_000281658.1\|1497651_1498110_+	ImmA/IrrE family metallo-endopeptidase	A0A2I6PEK4	Staphylococcus_phage	4.3e-65	82.1
WP_001033321.1\|1498126_1498855_+	staphylococcal enterotoxin type Q	A0EX09	Staphylococcus_phage	1.6e-26	34.1
WP_000734020.1\|1498878_1499607_+	staphylococcal enterotoxin type K	A0EX09	Staphylococcus_phage	1.2e-21	31.8
WP_000266158.1\|1499694_1500915_+\|integrase	site-specific integrase	Q4ZE80	Staphylococcus_phage	2.9e-100	47.5
WP_000732326.1\|1501057_1501879_-	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
1501058:1501074	attR	NA	NA	NA	NA
WP_000520233.1\|1501896_1502592_-	ABC transporter permease	NA	NA	NA	NA
WP_000571218.1\|1502584_1503610_-	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.2e-27	36.8

DBSCAN-SWA_8

1582320 : 1597051

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000616842.1\|1582320_1583082_-	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	8.5e-18	31.6
WP_001245577.1\|1583078_1584035_-	iron chelate uptake ABC transporter family permease subunit	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
WP_000876318.1\|1584021_1584993_-	ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
WP_000499195.1\|1585031_1585187_-	hypothetical protein	NA	NA	NA	NA
WP_000562498.1\|1585700_1586672_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
WP_000855505.1\|1586789_1588895_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
WP_000692521.1\|1588857_1589256_-	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
WP_001790091.1\|1589405_1589672_-	hypothetical protein	NA	NA	NA	NA
WP_001068497.1\|1590056_1590923_+	DMT family transporter	NA	NA	NA	NA
WP_000930014.1\|1590942_1591443_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
WP_001788366.1\|1591472_1591718_+	hypothetical protein	NA	NA	NA	NA
WP_000193752.1\|1591783_1593289_+	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
WP_001790641.1\|1593366_1593468_-	hypothetical protein	NA	NA	NA	NA
WP_000429014.1\|1593558_1594476_+	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	3.7e-07	22.0
WP_000197273.1\|1595099_1595642_-	5'-3'-deoxyribonucleotidase	NA	NA	NA	NA
WP_000663030.1\|1595992_1597051_-	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.9e-22	26.7

DBSCAN-SWA_9

1609023 : 1616843

Pandoravirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001217785.1\|1609023_1610175_-	anthranilate synthase component I family protein	A0A0B5J984	Pandoravirus	1.6e-23	35.7
WP_000604514.1\|1610158_1610752_-	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
WP_000446724.1\|1611102_1611771_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
WP_000941336.1\|1611772_1612192_+	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
WP_001062972.1\|1612195_1612909_+	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
WP_000637687.1\|1613007_1613592_+	hypothetical protein	NA	NA	NA	NA
WP_001093553.1\|1613871_1614312_+	DM13 domain-containing protein	NA	NA	NA	NA
WP_001037807.1\|1614653_1615127_+	DoxX family protein	NA	NA	NA	NA
WP_000149344.1\|1615101_1615788_+	response regulator transcription factor	NA	NA	NA	NA
WP_000244412.1\|1615787_1616843_+	HAMP domain-containing histidine kinase	A0A1V0SGX0	Hokovirus	2.1e-14	30.0

DBSCAN-SWA_10

1941952 : 1963561

Staphylococcus_phage(100.0%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000072584.1\|1941952_1943164_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	2.2e-44	35.2
WP_011443644.1\|1943156_1944896_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	4.4e-288	99.4
WP_001791797.1\|1944876_1945011_-	hypothetical protein	NA	NA	NA	NA
WP_001038688.1\|1945075_1945795_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.1e-131	100.0
WP_001038759.1\|1945945_1946662_-\|protease	serine protease SplE	A0A2H4PQN5	Staphylococcus_phage	1.1e-131	100.0
WP_011447030.1\|1946763_1946871_+	hypothetical protein	NA	NA	NA	NA
WP_001038704.1\|1946819_1947539_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	4.6e-130	99.6
WP_001038867.1\|1947659_1948379_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.2e-130	99.2
WP_001039447.1\|1948436_1949159_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	2.4e-131	99.6
WP_001039435.1\|1949283_1949991_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	2.6e-130	100.0
WP_001790219.1\|1950426_1950645_-	hypothetical protein	NA	NA	NA	NA
WP_001092763.1\|1950955_1951522_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	3.3e-99	100.0
WP_000586140.1\|1951995_1952694_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	3.8e-113	94.4
WP_000581552.1\|1952690_1953452_-	lantibiotic immunity ABC transporter MutE/EpiE family permease subunit	A0A2H4PQH2	Staphylococcus_phage	4.4e-131	100.0
WP_001096791.1\|1953448_1954141_-	lantibiotic protection ABC transporter ATP-binding subunit	A0A2H4PQG7	Staphylococcus_phage	6.2e-124	100.0
WP_000691541.1\|1954163_1955537_-	S8 family serine peptidase	A0A2H4PQH1	Staphylococcus_phage	2.9e-258	100.0
WP_000504439.1\|1955546_1956065_-	enterotoxin	A0A2H4PQG9	Staphylococcus_phage	2.0e-95	100.0
WP_000566596.1\|1956080_1957325_-	lanthionine synthetase C family protein	A0A2H4PQH9	Staphylococcus_phage	5.1e-238	100.0
WP_001092605.1\|1957317_1960311_-	lantibiotic dehydratase	A0A2H4PQG8	Staphylococcus_phage	0.0e+00	97.3
WP_000416756.1\|1960375_1960519_-	gallidermin/nisin family lantibiotic	A0A2H4PQH4	Staphylococcus_phage	5.3e-14	80.9
WP_001790705.1\|1960962_1961154_+	hypothetical protein	NA	NA	NA	NA
WP_000416759.1\|1961255_1961399_-	gallidermin/nisin family lantibiotic	NA	NA	NA	NA
WP_000782464.1\|1961640_1962624_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	2.3e-185	99.1
WP_000473596.1\|1962625_1963561_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0

DBSCAN-SWA_11

2061292 : 2148938

112

Staphylococcus_phage(92.31%)

portal,integrase,tail,head,terminase,protease,capsid,holin

attL 2110124:2110141|attR 2135055:2135072

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000827748.1\|2061292_2062459_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
WP_000434933.1\|2062489_2062816_+	staphostatin A	NA	NA	NA	NA
WP_000669862.1\|2063107_2063281_-	NETI motif-containing protein	NA	NA	NA	NA
WP_000011538.1\|2063261_2063864_-	DUF2179 domain-containing protein	NA	NA	NA	NA
WP_000040873.1\|2064134_2064956_-	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	1.8e-69	52.7
WP_000284431.1\|2064948_2066418_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	4.5e-108	45.1
WP_000897635.1\|2066601_2067678_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
WP_001177817.1\|2067697_2068492_+	prephenate dehydratase	NA	NA	NA	NA
WP_001802312.1\|2068563_2068671_+	hypothetical protein	NA	NA	NA	NA
WP_000323167.1\|2068681_2070244_-	SLC13 family permease	NA	NA	NA	NA
WP_000275730.1\|2070448_2071546_-	pectate lyase	U5PWM6	Bacillus_phage	1.9e-47	34.6
WP_000149686.1\|2071917_2072478_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
WP_001140871.1\|2072530_2073460_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
WP_001790680.1\|2073654_2073828_-	hypothetical protein	NA	NA	NA	NA
WP_001021214.1\|2073879_2075259_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_000181322.1\|2075378_2076407_-	lactonase family protein	NA	NA	NA	NA
WP_000205106.1\|2076676_2077078_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
WP_000267034.1\|2077650_2077824_-	hypothetical protein	NA	NA	NA	NA
WP_001188077.1\|2078274_2079315_+	linear amide C-N hydrolase	NA	NA	NA	NA
WP_000713072.1\|2079371_2080214_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_001033971.1\|2080210_2080768_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_000966288.1\|2080827_2081352_-	membrane protein	NA	NA	NA	NA
WP_000182842.1\|2081472_2082036_+	thioredoxin family protein	NA	NA	NA	NA
WP_001221651.1\|2082101_2082842_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
WP_000763048.1\|2082841_2083714_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
WP_000645727.1\|2083710_2084391_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
WP_000991302.1\|2084391_2085288_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
WP_000691584.1\|2085284_2085665_-	GntR family transcriptional regulator	NA	NA	NA	NA
WP_000681968.1\|2085928_2086105_-	hypothetical protein	NA	NA	NA	NA
WP_000990056.1\|2086347_2086446_-	hypothetical protein	NA	NA	NA	NA
WP_001068542.1\|2086645_2087932_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_001549158.1\|2088556_2090311_-	MAP domain-containing protein	NA	NA	NA	NA
WP_000669789.1\|2091268_2091448_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
WP_001795394.1\|2091471_2091780_+	hypothetical protein	M9NTD8	Staphylococcus_phage	2.1e-39	100.0
WP_001791826.1\|2091758_2092019_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
WP_000702263.1\|2092071_2092422_-	complement inhibitor SCIN-A	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
WP_000727649.1\|2093106_2093556_+	chemotaxis-inhibiting protein CHIPS	A0A1P8L6A8	Staphylococcus_phage	1.1e-78	100.0
WP_020444758.1\|2093650_2094109_-	amidase	R9QTN8	Staphylococcus_phage	4.9e-85	98.7
WP_000919350.1\|2094635_2095127_-	staphylokinase	A0A1X9H028	Staphylococcus_phage	9.5e-87	100.0
WP_000861038.1\|2095317_2096073_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
WP_000611512.1\|2096084_2096339_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
WP_001791821.1\|2096390_2096498_+	hypothetical protein	NA	NA	NA	NA
WP_011447039.1\|2096550_2096727_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
WP_000539688.1\|2096876_2097173_-	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
WP_001040261.1\|2097230_2097518_-	hypothetical protein	D2JLG1	Staphylococcus_phage	1.3e-43	100.0
WP_001153681.1\|2097564_2097717_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
WP_000582165.1\|2097706_2101492_-	hypothetical protein	A0A1X9H0H3	Staphylococcus_phage	0.0e+00	98.5
WP_000567394.1\|2101507_2102992_-\|tail	phage tail protein	A0A0H3U501	Staphylococcus_phage	2.0e-297	100.0
WP_001551779.1\|2102988_2107518_-\|tail	phage tail tape measure protein	A0A1X9H084	Staphylococcus_phage	0.0e+00	95.0
WP_001096354.1\|2107762_2108113_-	hypothetical protein	A0A0H3U503	Staphylococcus_phage	1.3e-58	100.0
WP_094969769.1\|2108162_2108402_-	hypothetical protein	A0A075LYE8	Staphylococcus_phage	4.0e-30	94.6
WP_000260578.1\|2108428_2109073_-\|tail	phage tail protein	A0A0H3U4E6	Staphylococcus_phage	6.5e-120	100.0
WP_000565500.1\|2109076_2109481_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	1.4e-67	95.5
WP_000114229.1\|2109477_2109882_-	hypothetical protein	A0A0H3U2V1	Staphylococcus_phage	8.7e-70	100.0
WP_000755150.1\|2109878_2110241_-\|head,tail	head-tail adaptor protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
2110124:2110141	attL	NA	NA	NA	NA
WP_000150936.1\|2110224_2110509_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
WP_000238236.1\|2110498_2110783_-	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
WP_000154559.1\|2110802_2111948_-\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
WP_000642728.1\|2111971_2112709_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
WP_000025274.1\|2112692_2113880_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
WP_000625088.1\|2113895_2115557_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
WP_000402904.1\|2115553_2115898_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
WP_000988336.1\|2116027_2116327_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
WP_000590122.1\|2116558_2116975_-	hypothetical protein	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
WP_000265043.1\|2117002_2117203_-	DUF1514 family protein	A0A2I6PDV9	Staphylococcus_phage	1.4e-28	100.0
WP_000595265.1\|2117202_2117352_-	transcriptional activator RinB	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
WP_000592207.1\|2117348_2117735_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
WP_000195803.1\|2117731_2117938_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
WP_001282074.1\|2117934_2118180_-	hypothetical protein	A0A2I6PDW7	Staphylococcus_phage	5.0e-36	100.0
WP_000181819.1\|2118216_2118750_-	dUTP pyrophosphatase	A0A0H3U2T1	Staphylococcus_phage	1.6e-95	100.0
WP_000700108.1\|2118742_2118985_-	hypothetical protein	A0A2I6PF40	Staphylococcus_phage	3.7e-36	100.0
WP_001065101.1\|2118974_2119211_-	DUF1024 family protein	A0A0H3U313	Staphylococcus_phage	5.3e-35	100.0
WP_001549172.1\|2119203_2119575_-	hypothetical protein	A0A0H3U4X7	Staphylococcus_phage	4.7e-54	97.3
WP_000131383.1\|2119583_2119826_-	hypothetical protein	A0A0H3U4B0	Staphylococcus_phage	1.1e-40	100.0
WP_000101288.1\|2119829_2120198_-	hypothetical protein	A0A0H3U2T3	Staphylococcus_phage	2.0e-49	100.0
WP_000401977.1\|2120210_2120615_-	RusA family crossover junction endodeoxyribonuclease	A0A0H3U2W2	Staphylococcus_phage	1.4e-72	100.0
WP_000338530.1\|2120623_2120842_-	hypothetical protein	A0A2I6PDG4	Staphylococcus_phage	1.0e-37	100.0
WP_000148333.1\|2120848_2121742_-	DnaD domain-containing protein	A0A1P8L6F0	Staphylococcus_phage	3.2e-141	100.0
WP_000934753.1\|2121771_2122242_-	single-stranded DNA-binding protein	A0A0H3U4B5	Staphylococcus_phage	4.4e-81	100.0
WP_071665632.1\|2122242_2122860_-	MBL fold metallo-hydrolase	A0A0H3U2T4	Staphylococcus_phage	4.1e-87	100.0
WP_000138475.1\|2122940_2123861_-	recombinase	A0A2I6PDH5	Staphylococcus_phage	2.3e-166	100.0
WP_000700561.1\|2123862_2125806_-	AAA family ATPase	A0A2I6PDH3	Staphylococcus_phage	0.0e+00	94.7
WP_001205732.1\|2125814_2126078_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
WP_000291513.1\|2126086_2126347_-	DUF1108 family protein	A0A0H3U2T6	Staphylococcus_phage	6.8e-44	100.0
WP_001549178.1\|2126386_2126647_-	DUF2482 family protein	A0A0H3U2W4	Staphylococcus_phage	9.3e-41	100.0
WP_001285960.1\|2126741_2126903_-	DUF1270 domain-containing protein	A0A0H3U4Y7	Staphylococcus_phage	3.8e-21	100.0
WP_001120199.1\|2126899_2127220_-	DUF771 domain-containing protein	A0A0H3U4C3	Staphylococcus_phage	1.5e-56	100.0
WP_000549548.1\|2127278_2127509_+	hypothetical protein	A0A0H3U2T9	Staphylococcus_phage	9.4e-37	100.0
WP_001148642.1\|2127697_2128450_-	oxidoreductase	A0A0H3U319	Staphylococcus_phage	5.6e-139	100.0
WP_000180411.1\|2128500_2128830_+	hypothetical protein	A0A0H3U4Z1	Staphylococcus_phage	4.6e-53	100.0
WP_001025404.1\|2128818_2129034_-	DUF2829 domain-containing protein	A0A0H3U4C7	Staphylococcus_phage	4.8e-35	100.0
WP_000854072.1\|2129049_2129313_-	helix-turn-helix transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	7.2e-41	100.0
WP_001801500.1\|2129309_2129483_-	hypothetical protein	NA	NA	NA	NA
WP_001031454.1\|2129445_2130159_+	helix-turn-helix transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
WP_000759682.1\|2130174_2131107_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
WP_000591749.1\|2131112_2131454_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
WP_000705246.1\|2131657_2131840_+	hypothetical protein	A0A0H3U4Z4	Staphylococcus_phage	4.1e-27	100.0
WP_001549185.1\|2131917_2132631_+	toxin MazF	A0A1X9H026	Staphylococcus_phage	5.0e-129	100.0
WP_000857199.1\|2132821_2133859_+\|integrase	site-specific integrase	A0A1X9H022	Staphylococcus_phage	3.8e-178	99.7
WP_000595324.1\|2134977_2135994_-	bi-component leukocidin LukGH subunit G	A0A2I6PER8	Staphylococcus_phage	1.1e-25	29.0
2135055:2135072	attR	NA	NA	NA	NA
WP_000791407.1\|2136015_2137071_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	2.8e-35	34.3
WP_000206639.1\|2137505_2138729_+	ArgE/DapE family deacylase	NA	NA	NA	NA
WP_000812010.1\|2139100_2139946_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000825510.1\|2140007_2140919_-	iron-hydroxamate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_001045079.1\|2141079_2142387_+	TrkH family potassium uptake protein	NA	NA	NA	NA
WP_000022887.1\|2143239_2143683_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_001797573.1\|2143847_2144225_-	hypothetical protein	NA	NA	NA	NA
WP_001293058.1\|2144542_2145133_-\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	1.1e-97	95.8
WP_000128898.1\|2145129_2145342_-	hypothetical protein	Q4ZE86	Staphylococcus_phage	1.1e-23	74.3
WP_000240645.1\|2146043_2147660_-	chaperonin GroEL	A0A240F779	uncultured_virus	3.4e-157	54.7
WP_000917289.1\|2147735_2148020_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2
WP_000197635.1\|2148194_2148938_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_CP043389.1|WP_001790641.1|1593366_1593468_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP043389.1|WP_001790641.1|1593366_1593468_-|hypothetical-protein

1593366_1593468_-

33 aa aa

1582320-1597051

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP043389_2	Orphan	2.4\|1442307\|26\|NZ_CP043389\|CRT	1442307-1442332	26	1585510-1585535	2
NZ_CP043389_5	Unclear	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	1585535-1585510	1
NZ_CP043389_5	Unclear	5.1\|1548447\|26\|NZ_CP043389\|CRISPRCasFinder	1548447-1548472	26	1585479-1585454	2

1. spacer 2.4|1442307|26|NZ_CP043389|CRT matches to NZ_CP043389 position: 1585510-1585535, mismatch: 2

ccgccagcctctgtgttggggccccg	CRISPR spacer
ccgcctgcttctgtgttggggccccg	Protospacer
***** **.*****************

2. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to NZ_CP043389 position: 1585535-1585510, mismatch: 1

cggggccccaacacagaagctggcgg	CRISPR spacer
cggggccccaacacagaagcaggcgg	Protospacer
******************** *****

3. spacer 5.1|1548447|26|NZ_CP043389|CRISPRCasFinder matches to NZ_CP043389 position: 1585479-1585454, mismatch: 2

cggggccccaacacagaagctggcgg	CRISPR spacer
cggggccccaacatagaagcaggcgg	Protospacer
*************.****** *****

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP043389

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information