CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP040393	Kosakonia radicincitans strain DSM 107547 plasmid pKrDSM107547, complete sequence	0 crisprs	NA	0	0	8	0
NZ_CP040392	Kosakonia radicincitans strain DSM 107547 chromosome, complete genome	1 crisprs	cas3,csa3,DEDDh,WYL,DinG,RT	0	0	8	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 11972

Macacine_betaherpesvirus(50.0%)

integrase,transposase

attL 67:80|attR 4557:4570

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
67:80	attL	NA	NA	NA	NA
WP_149289494.1\|73_295_+	hypothetical protein	NA	NA	NA	NA
WP_149289394.1\|377_1031_-	hypothetical protein	NA	NA	NA	NA
WP_149289395.1\|1060_1807_-	AAA family ATPase	NA	NA	NA	NA
WP_149289396.1\|2269_3046_+\|integrase	tyrosine-type recombinase/integrase	I3WFA4	Macacine_betaherpesvirus	1.1e-25	52.4
WP_149289397.1\|3066_4299_+	hypothetical protein	NA	NA	NA	NA
WP_149289398.1\|4426_5515_+	hsdR	NA	NA	NA	NA
4557:4570	attR	NA	NA	NA	NA
WP_149289399.1\|5673_6820_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	2.5e-146	92.2
WP_149289400.1\|7051_8419_+	hypothetical protein	NA	NA	NA	NA
WP_149289401.1\|8795_9542_-	replication initiation protein RepE	I3WF20	Macacine_betaherpesvirus	9.9e-128	88.3
WP_149289402.1\|10997_11972_+	StbA family protein	A0A222YXF2	Escherichia_phage	2.6e-67	45.4

DBSCAN-SWA_2

17115 : 17769

Faecalibacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149289407.1\|17115_17769_+	DNA methylase	A0A2K9VH43	Faecalibacterium_phage	2.0e-31	39.8

DBSCAN-SWA_3

26227 : 32534

uncultured_Caudovirales_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_004187019.1\|26227_26512_-	type II toxin-antitoxin system RelE/ParE family toxin	A0A2H4JBF4	uncultured_Caudovirales_phage	6.4e-19	55.9
WP_004187025.1\|26501_26750_-	plasmid stabilization protein	NA	NA	NA	NA
WP_149288265.1\|28251_29274_+\|transposase	IS21-like element ISSen3 family transposase	A0A2L1IVA1	Escherichia_phage	1.5e-174	85.3
WP_149288264.1\|29270_30053_+	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	3.9e-135	96.1
WP_149289418.1\|30989_32534_-	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	1.2e-10	32.9

DBSCAN-SWA_4

38233 : 39055

Cronobacter_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149289427.1\|38233_39055_+	DUF932 domain-containing protein	K4F5L3	Cronobacter_phage	4.2e-47	40.4

DBSCAN-SWA_5

45561 : 46428

Cronobacter_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149289488.1\|45561_46428_+	prohibitin family protein	K4F6D5	Cronobacter_phage	7.1e-53	54.8

DBSCAN-SWA_6

53870 : 54218

Escherichia_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149289444.1\|53870_54218_+	hypothetical protein	A0A222YY67	Escherichia_phage	6.8e-15	37.5

DBSCAN-SWA_7

83891 : 86252

Chrysochromulina_ericina_virus(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149289465.1\|83891_84659_-	SDR family oxidoreductase	A0A0N9R355	Chrysochromulina_ericina_virus	1.7e-21	29.0
WP_149289466.1\|84998_86252_+	starvation-sensing protein RspA	Q6A202	Oenococcus_phage	2.7e-45	30.9

DBSCAN-SWA_8

94364 : 116374

Escherichia_phage(22.22%)

integrase,transposase

attL 97184:97198|attR 117027:117041

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149289470.1\|94364_95495_-	diguanylate cyclase	G3MA91	Bacillus_virus	7.4e-18	33.2
WP_149289471.1\|96040_96619_-	recombinase family protein	A0A219YA40	Aeromonas_phage	1.9e-22	36.6
WP_149289472.1\|97049_97241_-	hypothetical protein	NA	NA	NA	NA
97184:97198	attL	NA	NA	NA	NA
WP_149289473.1\|97670_99329_+	HAMP domain-containing protein	A0A2H4J162	uncultured_Caudovirales_phage	1.1e-12	33.5
WP_149289493.1\|100360_100579_-	hypothetical protein	NA	NA	NA	NA
WP_149289474.1\|101196_101976_-\|integrase	tyrosine-type recombinase/integrase	I3WFA4	Macacine_betaherpesvirus	1.3e-50	88.4
WP_149289475.1\|101975_102794_-	hypothetical protein	NA	NA	NA	NA
WP_149289476.1\|102846_103149_-	hypothetical protein	NA	NA	NA	NA
WP_149289477.1\|103636_104512_+	hypothetical protein	NA	NA	NA	NA
WP_149288265.1\|104670_105693_+\|transposase	IS21-like element ISSen3 family transposase	A0A2L1IVA1	Escherichia_phage	1.5e-174	85.3
WP_149288264.1\|105689_106472_+	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	3.9e-135	96.1
WP_149289478.1\|106562_107693_+	hypothetical protein	NA	NA	NA	NA
WP_149289479.1\|107889_110694_-	hypothetical protein	A0A1B1IUG5	uncultured_Mediterranean_phage	1.7e-07	45.0
WP_072441258.1\|111072_111342_+	hypothetical protein	NA	NA	NA	NA
WP_149289480.1\|112000_112789_+	DUF3450 domain-containing protein	NA	NA	NA	NA
WP_149289481.1\|113040_113370_-	NIPSNAP family protein	NA	NA	NA	NA
WP_149289482.1\|113512_114412_-	DNA adenine methylase	A0A2K9R7J9	Dishui_lake_phycodnavirus	2.0e-13	25.7
WP_149289483.1\|115825_116374_-	recombinase family protein	Q1MVP4	Enterobacteria_phage	2.7e-74	79.1
117027:117041	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP040392

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP040392_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP040392_1

757184-757344

Orphan

Consensus_repeat	Method
GAGTCCGGAATCCGGACT	CRT

3 spacers

The CRISPR arrays of NZ_CP040392_1

>merge|NZ_CP040392|1|757184-757344|CRT
GAGTCCGGAATCCGGACTCAGTCAAAAAAGCACCAAAAACATCCCGGAATCACTGAGTCCGGAAAACGGACTCAGTACCACGTCAGTGGATAAAACACAGAGTCCGGAATCAGGACTTAGTCTGAAATCAACGAGTTACACCGGAGTCCGGAATCCGGACT

>NZ_CP040392|1|1|757184-757344|CRT
GAGTCCGGAATCCGGACT	CAGTCAAAAAAGCACCAAAAACATCCCGGAATCACT
GAGTCCGGAAAACGGACT	CAGTACCACGTCAGTGGATAAAACACA
GAGTCCGGAATCAGGACT	TAGTCTGAAATCAACGAGTTACACCG
GAGTCCGGAATCCGGACT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP040392.1\|WP_149288268.1\|754800_755544_+\|DUF2786-domain-containing-protein	unknown	unknown	gnl\|CDD\|378525
NZ_CP040392.1\|WP_063436962.1\|751493_752858_+\|replicative-DNA-helicase	unknown	unknown	gnl\|CDD\|273206
NZ_CP040392.1\|WP_149288267.1\|754553_754811_+\|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224648
NZ_CP040392.1\|WP_144135342.1\|746933_747857_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176166
NZ_CP040392.1\|WP_149288266.1\|752854_754561_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213858
NZ_CP040392.1\|WP_149288272.1\|758959_760972_+\|DNA-topoisomerase-III	unknown	unknown	gnl\|CDD\|236078
NZ_CP040392.1\|WP_149288277.1\|766913_768194_+\|type-4b-pilus-protein-PilO2	unknown	unknown	gnl\|CDD\|369114
NZ_CP040392.1\|WP_149288264.1\|748837_749620_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|181681
NZ_CP040392.1\|WP_149288275.1\|764774_765218_+\|type-IV-pilus-biogenesis-protein-PilM	unknown	unknown	gnl\|CDD\|369356
NZ_CP040392.1\|WP_149288270.1\|756227_756458_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP040392.1\|WP_149288273.1\|762175_762724_+\|single-stranded-DNA-binding-protein	unknown	unknown	gnl\|CDD\|236362
NZ_CP040392.1\|WP_149288276.1\|765237_766911_+\|PilN-family-type-IVB-pilus-formation-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274177
NZ_CP040392.1\|WP_149288269.1\|755628_756228_+\|DUF2857-family-protein	unknown	unknown	gnl\|CDD\|378591
NZ_CP040392.1\|WP_107146980.1\|762824_763256_+\|DUF29-domain-containing-protein	unknown	unknown	gnl\|CDD\|366774
NZ_CP040392.1\|WP_149288274.1\|763486_764773_+\|pilus-assembly-protein-PilL	unknown	unknown	gnl\|CDD\|163460
NZ_CP040392.1\|WP_072439405.1\|746073_746832_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
NZ_CP040392.1\|WP_149288265.1\|749616_750639_-\|IS21-like-element-ISSen3-family-transposase	unknown	unknown	gnl\|CDD\|226950
NZ_CP040392.1\|WP_149288278.1\|768180_768678_+\|type-IV-pilus-biogenesis-protein-PilP	unknown	unknown	gnl\|CDD\|274394
NZ_CP040392.1\|WP_107146982.1\|761605_762100_+\|DUF3577-domain-containing-protein	unknown	unknown	gnl\|CDD\|371899
NZ_CP040392.1\|WP_107146984.1\|758222_758942_+\|TIGR03761-family-integrating-conjugative-element-protein	unknown	unknown	gnl\|CDD\|274771

Protein	Function_ID	Function_description	E-value
NZ_CP040392.1\|WP_149288268.1\|754800_755544_+\|DUF2786-domain-containing-protein	gnl\|CDD\|378525	pfam10979, DUF2786, Protein of unknown function (DUF2786). This family of proteins has no known function.	4.86894e-10
NZ_CP040392.1\|WP_063436962.1\|751493_752858_+\|replicative-DNA-helicase	gnl\|CDD\|273206	TIGR00665, DnaB, replicative DNA helicase. This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP040392.1\|WP_149288267.1\|754553_754811_+\|TraR/DksA-family-transcriptional-regulator	gnl\|CDD\|224648	COG1734, DksA, DnaK suppressor protein [Signal transduction mechanisms].	5.61891e-12
NZ_CP040392.1\|WP_149288266.1\|752854_754561_+\|hypothetical-protein	gnl\|CDD\|213858	TIGR03764, ICE_PFGI_1_parB, integrating conjugative element, PFGI_1 class, ParB family protein. Members of this protein family carry the ParB-type nuclease domain and are found in integrating conjugative elements (ICE) in the same class as PFGI-1 of Pseudomonas fluorescens Pf-5.	1.55404e-144
NZ_CP040392.1\|WP_149288272.1\|758959_760972_+\|DNA-topoisomerase-III	gnl\|CDD\|236078	PRK07726, PRK07726, DNA topoisomerase 3.	0
NZ_CP040392.1\|WP_149288277.1\|766913_768194_+\|type-4b-pilus-protein-PilO2	gnl\|CDD\|369114	pfam06864, PAP_PilO, Pilin accessory protein (PilO). This family consists of several enterobacterial PilO proteins. The function of PilO is unknown although it has been suggested that it is a cytoplasmic protein in the absence of other Pil proteins, but PilO protein is translocated to the outer membrane in the presence of other Pil proteins. Alternatively, PilO protein may form a complex with other Pil protein(s). PilO has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body. This family does not seem to be related to pfam04350.	1.27134e-57
NZ_CP040392.1\|WP_149288264.1\|748837_749620_-\|ATP-binding-protein	gnl\|CDD\|181681	PRK09183, PRK09183, transposase/IS protein; Provisional.	1.39849e-176
NZ_CP040392.1\|WP_149288275.1\|764774_765218_+\|type-IV-pilus-biogenesis-protein-PilM	gnl\|CDD\|369356	pfam07419, PilM, PilM. This family contains the bacterial protein PilM (approximately 150 residues long). PilM is an inner membrane protein that has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body.	1.07635e-24
NZ_CP040392.1\|WP_144135342.1\|746933_747857_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176166	cd08477, PBP2_CrgA_like_8, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 8. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.30082e-91
NZ_CP040392.1\|WP_149288273.1\|762175_762724_+\|single-stranded-DNA-binding-protein	gnl\|CDD\|236362	PRK09010, PRK09010, single-stranded DNA-binding protein; Provisional.	3.58414e-93
NZ_CP040392.1\|WP_149288276.1\|765237_766911_+\|PilN-family-type-IVB-pilus-formation-outer-membrane-protein	gnl\|CDD\|274177	TIGR02520, putative_Type_IV_pilus_protein, type IVB pilus formation outer membrane protein, R64 PilN family. Several related protein families encode outer membrane pore proteins for type II secretion, type III secretion, and type IV pilus formation. This protein family appears to encode a secretin for pilus formation, although it is quite different from PilQ. Members include the PilN lipoprotein of the plasmid R64 thin pilus, a type IV pilus. Scoring between the trusted and noise cutoffs are examples of bundle-forming pilus B (bfpB). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking].	4.89398e-122
NZ_CP040392.1\|WP_149288269.1\|755628_756228_+\|DUF2857-family-protein	gnl\|CDD\|378591	pfam11198, DUF2857, Protein of unknown function (DUF2857). This is a bacterial family of uncharacterized proteins.	2.11232e-67
NZ_CP040392.1\|WP_107146980.1\|762824_763256_+\|DUF29-domain-containing-protein	gnl\|CDD\|366774	pfam01724, DUF29, Domain of unknown function DUF29. This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Structure 3fcn is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerization module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.	7.05334e-61
NZ_CP040392.1\|WP_149288274.1\|763486_764773_+\|pilus-assembly-protein-PilL	gnl\|CDD\|163460	TIGR03748, conj_PilL, conjugative transfer region protein, TIGR03748 family. This model describes the conserved N-terminal region of a variable length protein family associated with laterally transfered regions flanked by markers of conjugative plasmid integration and/or transposition. Most members of the family have the lipoprotein signal peptide motif. A member of the family from a pathogenicity island in Salmonella enterica serovar Dublin strain was designated PilL for nomenclature consistency with a neighboring gene for the pilin structural protein PilS. However, the species distribution of this protein family tracks much better with markers of conjugal transfer than with markers of PilS-like pilin structure. [Mobile and extrachromosomal element functions, Plasmid functions].	1.23395e-54
NZ_CP040392.1\|WP_072439405.1\|746073_746832_-\|SDR-family-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	1.18105e-69
NZ_CP040392.1\|WP_149288265.1\|749616_750639_-\|IS21-like-element-ISSen3-family-transposase	gnl\|CDD\|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	6.77835e-68
NZ_CP040392.1\|WP_149288278.1\|768180_768678_+\|type-IV-pilus-biogenesis-protein-PilP	gnl\|CDD\|274394	TIGR03021, pilP_fam, type IV pilus biogenesis protein PilP. Members of this protein family are found in type IV pilus biogenesis loci and include proteins designated PilP. [Cell envelope, Surface structures].	1.04678e-18
NZ_CP040392.1\|WP_107146982.1\|761605_762100_+\|DUF3577-domain-containing-protein	gnl\|CDD\|371899	pfam12101, DUF3577, Protein of unknown function (DUF3577). This family of proteins is functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 143 to 307 amino acids in length.	1.85567e-62
NZ_CP040392.1\|WP_107146984.1\|758222_758942_+\|TIGR03761-family-integrating-conjugative-element-protein	gnl\|CDD\|274771	TIGR03761, ICE_PFL4669, integrating conjugative element protein, PFL_4669 family. Members of this protein family, such as PFL4669, are found in integrating conjugative elements (ICE) of the PFGI-1 class as in Pseudomonas fluorescens.	3.10078e-84

>NZ_CP040392.1|WP_149288270.1|756227_756458_+|hypothetical-protein
MEMGDFSPRQQVSPAVRRRAQQLFRAACVGQKVFRRLTMNGYLKIDVGPFWRILSKDGGRQWWLMDHETYNREIRR
>NZ_CP040392.1|WP_149288269.1|755628_756228_+|DUF2857-family-protein
MSQHNLSQATTAILSSLLMDVKNGNIRRCESLGMSVEEIRALSHLSLDELHYLSQSHVSVLDVTLNHENFWLMLNQARNEQKRFMMIDRALELGGSMELIDRYFGLSPSEVSARRRLMGIESRQGRTQALTEPQDAALWAEWKAAGLSSPDSHQALEAMMLAAEQLGLSLTAVWSRVCQWCREANAAGRRSEIPVRKEA
>NZ_CP040392.1|WP_149288268.1|754800_755544_+|DUF2786-domain-containing-protein
MSDNAKITARIRRLMALGTRNSNPHEAARAVALAQRLMQRHGLTPDMLSLSDVSESVCFSLTSDAEKVPAWLSSLATVVCMATGCRCWFGWHIHVSPQGVSSVRRSLHFYGFSERPEVALYIYTVLQRQLRAATDAHMSGYRTRRILLRTRRRRADQFREGWVSGVWQVLQSFAPSGEENAVLQRWLAQRHAGEPLEDMAVRSAGKCRGDRTARVAGFFAGRDTDLHHGLSGAQASRQITAGGHAHD
>NZ_CP040392.1|WP_149288267.1|754553_754811_+|TraR/DksA-family-transcriptional-regulator
MSDDLNDEMAQASTALFIQHGIDAIRAKVNSATQSKAFCECCGAAIPVARQLAVPGVELCAGCQEVKEMKNRHRADGGRGMRHVG
>NZ_CP040392.1|WP_149288266.1|752854_754561_+|hypothetical-protein
MSNVRNLNLGAAMLQRGKTPAQGDAVPAAVPLPVSEMAMVLTLDQLRPNPDNPRKSRNPHFDEIKASIRACGLVQVPKVTRDPDGEDVYIFSDGGNTRYQILCELWQETGDERFYRVHTIFKPWPGRLKCLVGHLAENEVRGDLSYIDKAFGIHKARTIQEEQMGRSVSLRELSDLLNAEGYPVHASSISRMEDTLKYLHPYMPDLLENGLSRGQVLPILNLRSLAEKVWSKYDISDNSADEFERVFGEACRNFNDPDGFSFDHLRDELIGHLVKALPHPSLNYDRWMIELDPREQKRREQFGEPPPLPVLTPPPERAAGREPPEPQVTVLPPDTASETPATGLRSGTLTTPGRPEPAPELHADAELPVNTLVTAGSEPRREVQNDLFGGRPVISGETADPDSISLPDFSPGTLMSAFGEENASPAASVSSVAFAATGLEPVSDIWHIPALQDDIEHLQDMAYRLVFEIAEVMGCADNVREDKHPQSAGFAVSETGSEFVLFLAGLSGSLPNRQFNMFMFCLNFFGSQSPADMAVFDDITVVKTMRLIRVIRRLRELQRLAAKGGENV
>NZ_CP040392.1|WP_063436962.1|751493_752858_+|replicative-DNA-helicase
MSEQKQVISGLFSRDAEQSVLGGLMLDNDCWDEVALLVSTDDFYYHVHRTIFREMTRLISRGKPIDLITLAESIESQGTNVLEQLGGFAYLAELSKNTPSAANIRAYCEIVAKYSQARQLARIGADITENVQKPGADIPAVMEEAEQKITRLAERAEPEQAHTLIDGMDRLLTELERRCNTPDGITGAATGFKEFDDLTSGLQAGDLVLVAARPSMGKTAFLISLLLNHMMKTPDSRGQFYSLEQPEEQILMRMVSSLSSLELQRLKSGLMDDEDWARVSEAYKICTEDFNARLVIDDTSGLTPQMLRIRTRRNARRYGAPSIIGLDYLQLMRSPEQENRTQEIAEISRSLKALAKEMACPVVALSQLNRSLESRQDKRPNNGDLRDSGALEQDADVIVFIYRDEVYHENTEDKGIAEIIISKQRQGPTGTIRLQYEGRFTRFSDIAGRPGRSA
>NZ_CP040392.1|WP_149288265.1|749616_750639_-|IS21-like-element-ISSen3-family-transposase
MITFEIRMEIKVLHKRGMSIRAIARELGISRNTVRSHLKAKSEKPQYSPRPVSSSLLDEYRDYISKRISDAHPYKIPATVIAREIMELGYRGGLTILREFIRKQTLPAQAEPVVRFETEPGRQMQVDWGTMRNGKSPLHVFVAVLGYSRMLYIEFTDNMRYDTLEACHRNAFSFFGGVPQEVLYDNMKTVVLQRDAYQTGQHRFHPSLWQFGKEMGFSPRLCRPFRAQTKGKVERMVQYTRNSFYIPLMTRLRPMGITVDVETANRYGLRWLYDVANQRKHETIQTRPCDRWVEEQQSMLALPPEKKQYDVQVDESLMTFDRQPLHHPLSIYDTFCRGAA
>NZ_CP040392.1|WP_149288264.1|748837_749620_-|ATP-binding-protein
MMVELQHQRLMVLAEQLQLDSLIGAAPALSQQAVDQEWSYMDFLEHLLHEEKQARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQIQSLRSLSFIERNENIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTSQRQGRYKTTLNRGVMAPKLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGDAALTSAMLDRILHHSHVVQIKGESYRLKQKRKAGVIAEANPE
>NZ_CP040392.1|WP_144135342.1|746933_747857_+|LysR-family-transcriptional-regulator
MDLFRAMTVFAEVARSGSMSAASRKLLITPAMVGQYIAALEDRLGMRLLNRTTRKQKLTDFGLSYLEQCHDILERVVASETQAEGLQHSFGGKLRLTAPISFGTECLIPALQRYRKMAPDVEIDITLTDRVIDLVDEGIDIAFRIGELNDSSMIGRPLMPYRMAVCASPEYLQAYGTPAHPSELFEHQLLSLSTSSRSPWRLSRGEEKIEIPVHSKLTINNGQALRVAARSGLGIVMQPEILLSEDMISGRLVRLFQEWHIRERQVWLLYLRDKRMTPKIRAFINFSLEAFSAGKVEANPHNQPLTP
>NZ_CP040392.1|WP_072439405.1|746073_746832_-|SDR-family-oxidoreductase
MNRLRFVDKTVVVTGAGSGMGRTAAIRLASEGAKVMLLGRQAGMLEEVRDEIKRADGLSYVFPCDIRSQSQVEKTFTAVASVCGQVDALFANAGYLGAFKPLAEADIADFSEPLETNLNGTFLTIRHCLPLIKKGAILINASWTTGSVMPGAGIYAATKAALLAIMRTLAVECGPRGIRVNAVSPGVILTPMAASALPEETVNALASRSLLQRNGVPEDISGTVAWLLSDDASYVTGQEIMVDGGFTIGGMR
>NZ_CP040392.1|WP_107146984.1|758222_758942_+|TIGR03761-family-integrating-conjugative-element-protein
MAEKQKRAGALQSELHIELHTNYAIGLWEGRKRESREDGKKGKQPIMGMPQFLYRATLINKDSIQNDPWADMAMLALEEKIEYAGRQMNSLIASLDKQMSFIPAGVTISDAQATEPLDLTVFSGTPLGYRCVFLLMGFDQFAKKVLQAAHYGVISRTQRYELLGDGSRLLREIYGCVLRYRKTGATRLDAVENNEVWQKACQEAGEPDRAVLLGEKRSAFSPPVNEASVNLLRLRYQTV
>NZ_CP040392.1|WP_149288272.1|758959_760972_+|DNA-topoisomerase-III
MRLYICEKPSQGRDLAGVLGATRRGDGFLTGSGVTVTWAVGHLLETAPPEAYGQQYGKPWSLSALPILPAPWQVVVKKETQDQFKVIERLLRQVDDVVIATDADREGEVIARELLEYCRWEGPVQRLWLSALDELSIRAALQDLRPGQATLGMYHAGLGRARADWLIGMNLSRLYTLRAAEAGFDGVVSVGRVQTPTLALVVRRDREITAFVPKPFWQVKALISAGGLTFPVQWVPAKVYTDEEKRCVHQNIAQQVAQLCRQAGHAVVTECDTKREKAAAPLAFSLGSLQQACGRLWDMSPQQVLDTAQSLYEKHKATTYPRTDCGYLPESMREEISGVLDAIGRTDPECAPVLARLDRAFVSRIWNDKKITAHHGIIPTRNAFQLSALTETERNVYLLVRRNYLAQFLPLHESDFTRLQFDTGGQLFRATGRTEVIKGWKVLFENAGDNEVDGGDEADVALPPLAQNDRCAVTGAEVVQLMTRPPAHYTFATLIGAMMNAAAFVTDVALRKVLKDNAGLGTEATRAGIVEQLLNRHFIVRKGSKIMATELGSDVIDALPPQLTEPGMTALWEQALDEVAAGRMSLDDFLQRQAGWTRNLVSQGSQQQVRIRVPPTPACPLCGGKTRLRRGEKGEFWSCQRWPECKGVINIGNTKKKRPRRSKSPESKKN
>NZ_CP040392.1|WP_107146982.1|761605_762100_+|DUF3577-domain-containing-protein
MTATTQTPASNGSASGTQQKKEFFNLNVNGIGYLSSIRRVQGGNGEFTCAVINALTGPTDNASYTRFDVTIAGAETTKLINRCQKAVDEEEKVLIGFVLSGLKADVFTLQTGDHAGESRPSLKARLIKVEFIKKGQDVVYQAPNASQTPESGSSAQKEYDPNSF
>NZ_CP040392.1|WP_149288273.1|762175_762724_+|single-stranded-DNA-binding-protein
MSARGVNKVILVGHLGQDPEVRYMPDSTAVTTLSVATSETWRDKQTGENRENTEWHRVVLFGKLAEVAGEYLRKGSQVYIEGQLRTRKWTDTNGIERWTTEVRVGVNGTMQMLGGGRNNSTNTSGNNAQSGQQGGWGQPQQPQQTPSAPRNPQNEPPMDFDDDIPFLGHGYGICRKAIYAIS
>NZ_CP040392.1|WP_107146980.1|762824_763256_+|DUF29-domain-containing-protein
MNTRYEADVVAWAQEQAALLRAGRFSEIDIANIAEEIEDVGKSEKRELASRMAVLLAHLLKWKFQPGRRGSSWQRTIKEQRKALALHIKGTPSLKTALSDTDWIATVWADAVSSAAQETQLDVFPEDCIWDMGQILSQEFYPE
>NZ_CP040392.1|WP_149288274.1|763486_764773_+|pilus-assembly-protein-PilL
MAVPSRRVATGAALLACSVIQAGCSSAVSDPAPFANGRYQQPTRFDDIYRNRAPDVVRYDRYTLVSTRPDDAQRDPLNQIVDITMPAQLVKTVGEGFRYLLLESGYSLCSATTSAFSELLSRPLPAVQRDIGPVRLSEALQIVAGPAWRLRVDDVNREICFELRDPYRSFAAPLPAPVSLVSQHAPVSLPPVIQPARTGGDAGTVNAVPRNPFTGDTRINSTPGTLQKPVLTAQNQSVPSPVLTVAKTPAAQKSAALSPAGRPPVPPPAAAPKAASSQKTPVTAVHPVTVQPATVNAARQTVPVRPVTSLPPAPPVSGQTASSYIPGAPVTPQPVGQTWRAEPGSTLKETLTGWASKATCSNGGNWVVIWPVSLDYRIDAPLVFHGNFESVLVQVFDLYRKAEKPLFAEANRIQCLISVSDTPTGGGH
>NZ_CP040392.1|WP_149288275.1|764774_765218_+|type-IV-pilus-biogenesis-protein-PilM
MGYALPVFVCCLVIALMAGDAQRHSAEHVRLSLQQTLPDQLATDMLRTADAVNNWRHGRTVADGTVTPAQAGIVPAPDSRIQTVIQGGRLWVWVPATDGVYAALRTQSVTSALALTVSGGRLRMADGTDMNLSLPSGVTEGSIVYLN
>NZ_CP040392.1|WP_149288276.1|765237_766911_+|PilN-family-type-IVB-pilus-formation-outer-membrane-protein
MPRLPFCLTALAAALALSSCSLNEISKMDKEASGQADTAQRVLQSRQTLTQPTVVWSDKPWVNLQPVTPVISTPDEKNLPACQITINRPEGISLPELGQRITALCGIRVSITPDAFAALSSISTGSVVTSQMNGQLPAPDDNGRVPLSQMGTTSAQPVSVQSSPSLIRGLKYQGDIRGLLDMAASGLGLSWRSDSSGVYFYQQDTRTFQLVILNTKVNSSASINSGSGNQLGSGGGTSGGTTGDISSNQKTDYGMNSDLYDDIKKTVEQMVTPKSGRFWLSSATGTLSVTDTPDVLNRIGRYIEYQNKVLSRQVQLNIQIVSVNQTRNEQMGLDWGLVYKSLQNVGASLTGSMANASSSAASAGISILDTASGNAAKFSGSSLLIHALSEQGNVSMALNQTDPTANLTPVAYQLSKSTGMLTSSSSTATANVGVTSTMTTTNVTTGLFMTMLPFIQENGDVQLQFAFSYTSPPNIKSFVSRDGNTRNDTADTSTEGLARKVNLRSGQTLVLTGSEQQNVSADKQGTFTPGNFILGGGQTGSRGRTTLVIMITPVLLR
>NZ_CP040392.1|WP_149288277.1|766913_768194_+|type-4b-pilus-protein-PilO2
MSLQKKTTRRTGIRLTHHRRDWMAGLHWAPQHSALRVRLRGRASPDTHCVTAGRGSASMAGVVSPGRVRHRLYALAVAFQLSEGGNAWGIYRLSRDEDLWVFFAASGGQLSVMGDVTGTRAFIESAAQNFLRFNDADAPGLRCAATAEDGRDATTLTDRLSGAQLRHCRLRKRLTPLSLILPAVVMTFAVASGTYWYDVASQKAEQAAAAAAFRARMAMTPETKVAPARAPHPWASQPPVSLLLSNCWLTREPLYASVAGWRFSDGECVPEGLRERFIATPGATVEDFARRVKELFGLSAVFNLSEGGKNGDIFIPFRKYRAGEYTDEVLPGADAQLMRFISHLQRRNLDVKFTEVKPPAVAPGQEKNTPVQDWREFTFSVSSRLQPELLMQDFDATGLRLTSVSITMSPKGQYAYTIKGSIYAQN
>NZ_CP040392.1|WP_149288278.1|768180_768678_+|type-IV-pilus-biogenesis-protein-PilP
MRRINSAGWLLMLFALLLGDARATTVSDTLPTNVTQGELETAQARILILEQKVQTARLEQQLRESQSGQSTDRNYLATSLQPSAPLMTQPVPSQTAATSGTEKRAGSVRLQEIYGRGTQLRARIVLPDGGVTEVAKGDQIPGTAKRVTEVTSTLVRLSDNSELSF

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1357662 : 1424340

Escherichia_phage(24.39%)

plate,tail,lysis,tRNA,holin,integrase

attL 1369110:1369127|attR 1411229:1411246

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_007370710.1\|1357662_1358430_+\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
WP_002914145.1\|1358474_1358822_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_071531981.1\|1358977_1359169_-	late control protein B	Q37973	Salmonella_virus	1.3e-20	71.9
WP_071921213.1\|1359243_1360386_-	hypothetical protein	Q7Y4C6	Escherichia_virus	1.1e-106	53.1
WP_007370713.1\|1360382_1360844_-\|tail	tail assembly protein	A0A0F7LBX3	Escherichia_phage	5.6e-49	64.1
WP_149288438.1\|1360840_1362553_-\|tail	phage tail tape measure protein	S4TP64	Salmonella_phage	5.2e-31	39.1
WP_061493592.1\|1362545_1362665_-\|tail	GpE family phage tail protein	A0A0F7LCR6	Escherichia_phage	7.5e-14	87.2
WP_007370715.1\|1362697_1362979_-\|tail	phage tail assembly protein	A0A0F7LDQ8	Escherichia_phage	2.7e-30	79.5
WP_007370716.1\|1363041_1363560_-\|tail	phage major tail tube protein	Q858V0	Yersinia_virus	4.5e-87	90.1
WP_007370717.1\|1363572_1364754_-\|tail	phage tail sheath protein	S4TRX2	Salmonella_phage	1.3e-201	88.3
WP_149288439.1\|1364883_1365477_-\|tail	tail fiber assembly protein	M1SV83	Escherichia_phage	6.4e-45	49.5
WP_144136255.1\|1365476_1366598_-\|tail	phage tail protein	M1TAS6	Escherichia_phage	1.2e-116	48.9
WP_144136256.1\|1366795_1367392_-\|tail	tail fiber assembly protein	A0A218M4J2	Erwinia_phage	6.8e-63	58.4
WP_072439244.1\|1367391_1368447_-\|tail	phage tail protein	M1TAS6	Escherichia_phage	3.5e-110	47.5
WP_149288440.1\|1368601_1369552_-\|tail	phage tail protein	A0A2I8TVA9	Erwinia_phage	1.4e-78	77.2
1369110:1369127	attL	NA	NA	NA	NA
WP_007370724.1\|1369706_1370315_-\|tail	phage tail protein I	A0A218M4J3	Erwinia_phage	4.5e-86	76.0
WP_144136258.1\|1370307_1371216_-\|plate	baseplate assembly protein	A0A218M4K5	Erwinia_phage	1.2e-130	79.5
WP_007370726.1\|1371220_1371568_-\|plate	baseplate assembly protein	A0A0F7LDQ1	Escherichia_phage	2.8e-40	73.0
WP_144136259.1\|1371564_1372200_-\|plate	phage baseplate assembly protein V	A0A0F7LDY9	Escherichia_phage	2.4e-90	78.7
WP_072439247.1\|1372287_1372755_-\|tail	phage tail protein	A0A0F7LA33	Escherichia_phage	4.8e-48	60.1
WP_149288441.1\|1372850_1373276_-\|lysis	LysB family phage lysis regulatory protein	A0A218M4K2	Erwinia_phage	5.6e-27	53.1
WP_149288442.1\|1373272_1373782_-	glycoside hydrolase family protein	A0A218M4K3	Erwinia_phage	4.3e-66	75.5
WP_064564426.1\|1373765_1373987_-\|holin	holin	A0A218M4L5	Erwinia_phage	5.0e-11	43.8
WP_035888416.1\|1373977_1374181_-\|tail	tail protein X	Q858W3	Yersinia_virus	3.5e-19	66.7
WP_035888419.1\|1374379_1374565_-	hypothetical protein	A0A0M5M1G5	Salmonella_phage	6.0e-10	55.7
WP_149288443.1\|1374636_1376610_-	replication endonuclease	A0A218M4H2	Erwinia_phage	5.4e-266	72.4
WP_007370737.1\|1376610_1376832_-	TraR/DksA family transcriptional regulator	Q6K1F5	Salmonella_virus	6.9e-21	69.0
WP_007370738.1\|1376831_1377059_-	DUF2732 family protein	A0A218M4I9	Erwinia_phage	4.2e-05	40.0
WP_035888424.1\|1377126_1377465_-	DUF5347 domain-containing protein	A0A218M4I7	Erwinia_phage	3.3e-38	68.5
WP_007370740.1\|1377503_1377881_-	hypothetical protein	A0A0M4R4X7	Salmonella_phage	6.0e-41	69.2
WP_149288444.1\|1377996_1378845_+	phage repressor protein CI	Q6K1G0	Salmonella_virus	4.8e-94	61.7
WP_149288445.1\|1378851_1379901_+\|integrase	tyrosine-type recombinase/integrase	A0A0M4S6G4	Salmonella_phage	1.1e-153	73.9
WP_149288446.1\|1380089_1380500_+	DUF2946 family protein	NA	NA	NA	NA
WP_035888433.1\|1380562_1381927_+	PepSY domain-containing protein	NA	NA	NA	NA
WP_149288447.1\|1382107_1383178_+	3-deoxy-7-phosphoheptulonate synthase AroF	A0A0F6R6T6	Escherichia_coli_O157_typing_phage	3.7e-91	51.5
WP_149288448.1\|1383187_1384309_+	bifunctional chorismate mutase/prephenate dehydrogenase	NA	NA	NA	NA
WP_149288449.1\|1384375_1385248_+	SMP-30/gluconolactonase/LRE family protein	NA	NA	NA	NA
WP_007370749.1\|1385244_1386405_-	bifunctional chorismate mutase/prephenate dehydratase	NA	NA	NA	NA
WP_007370750.1\|1386652_1386991_-	ribosome-associated translation inhibitor RaiA	NA	NA	NA	NA
WP_007370751.1\|1387256_1387994_-	outer membrane protein assembly factor BamD	NA	NA	NA	NA
WP_007370752.1\|1388125_1389106_+	23S rRNA pseudouridine(1911/1915/1917) synthase RluD	NA	NA	NA	NA
WP_149288450.1\|1389102_1389834_+	polyphenol oxidase	NA	NA	NA	NA
WP_007370754.1\|1389963_1392537_+	ATP-dependent chaperone ClpB	H6X3M6	Enterobacteria_phage	1.9e-125	34.6
WP_149288451.1\|1398247_1399546_+	MFS transporter	Q6JIH2	Burkholderia_virus	6.9e-44	31.8
WP_035888232.1\|1399542_1399866_-	YfiM family lipoprotein	NA	NA	NA	NA
WP_007370760.1\|1399911_1401267_-	CDP-diacylglycerol--serine O-phosphatidyltransferase	NA	NA	NA	NA
WP_144136352.1\|1401380_1404041_-	protein lysine acetyltransferase	NA	NA	NA	NA
WP_035888226.1\|1404073_1404772_-	DTW domain-containing protein	NA	NA	NA	NA
WP_007370763.1\|1404841_1405261_-	thioredoxin TrxC	A0A1J0GW78	Streptomyces_phage	2.0e-13	41.5
WP_007370764.1\|1405467_1406565_+\|tRNA	tRNA/rRNA methyltransferase	NA	NA	NA	NA
WP_007370765.1\|1406610_1407300_-	uracil-DNA glycosylase	A0A077BCN4	Equid_alphaherpesvirus	4.6e-55	51.4
WP_007370766.1\|1407612_1407996_+	autonomous glycyl radical cofactor GrcA	A0A193GZ98	Escherichia_phage	3.1e-32	71.8
WP_149288452.1\|1408039_1409368_-	ATP-dependent RNA helicase SrmB	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.3e-42	30.4
WP_007370768.1\|1409497_1410235_+\|tRNA	tRNA1(Val) (adenine(37)-N6)-methyltransferase	NA	NA	NA	NA
WP_007370769.1\|1410219_1411842_-	L-aspartate oxidase	NA	NA	NA	NA
1411229:1411246	attR	NA	NA	NA	NA
WP_007370770.1\|1412262_1412838_+	RNA polymerase sigma factor RpoE	NA	NA	NA	NA
WP_035888221.1\|1412869_1413523_+	anti-sigma-E factor RseA	NA	NA	NA	NA
WP_071921197.1\|1413522_1414476_+	sigma-E factor regulatory protein RseB	NA	NA	NA	NA
WP_007370773.1\|1414472_1414952_+	SoxR-reducing system protein RseC	NA	NA	NA	NA
WP_035888216.1\|1415097_1416897_+	elongation factor 4	E4ZFJ7	Streptococcus_phage	7.2e-23	25.2
WP_035888214.1\|1416912_1417887_+	signal peptidase I	NA	NA	NA	NA
WP_007370776.1\|1418099_1418780_+	ribonuclease III	E5EQH1	Micromonas_sp._RCC1109_virus	1.3e-20	33.5
WP_007370777.1\|1418776_1419688_+	GTPase Era	NA	NA	NA	NA
WP_079518375.1\|1419795_1420503_+	DNA repair protein RecO	NA	NA	NA	NA
WP_071921195.1\|1420568_1421300_+	pyridoxine 5'-phosphate synthase	NA	NA	NA	NA
WP_007370780.1\|1421299_1421680_+	holo-ACP synthase	NA	NA	NA	NA
WP_007370781.1\|1421676_1421937_-	YfhL family 4Fe-4S dicluster ferredoxin	A0A1B1IWY9	uncultured_Mediterranean_phage	1.1e-17	52.3
WP_007370782.1\|1421993_1422842_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_035888209.1\|1423127_1423763_+	phosphatidylglycerophosphatase C	NA	NA	NA	NA
WP_007370784.1\|1423821_1424340_+\|tRNA	tRNA adenosine(34) deaminase TadA	S4VYT2	Pandoravirus	7.3e-05	42.2

DBSCAN-SWA_2

1608971 : 1675771

Tetraselmis_virus(20.0%)

plate,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035889017.1\|1608971_1610513_+\|holin	choline-sulfatase	A0A2P0VMN7	Tetraselmis_virus	8.6e-09	21.5
WP_149288480.1\|1610515_1611460_+\|holin	choline ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_071921140.1\|1611766_1612855_+	YncE family protein	NA	NA	NA	NA
WP_072440008.1\|1612906_1615120_+	TonB-dependent siderophore receptor	NA	NA	NA	NA
WP_007370960.1\|1615116_1616016_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_144134913.1\|1616112_1616637_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_149288481.1\|1616647_1618051_-	glutamine synthetase	NA	NA	NA	NA
WP_007370964.1\|1618340_1618601_+	DUF2534 family protein	NA	NA	NA	NA
WP_035889025.1\|1618888_1620829_+	methyl-accepting chemotaxis protein	NA	NA	NA	NA
WP_007370967.1\|1620843_1621230_-	hypothetical protein	NA	NA	NA	NA
WP_035889029.1\|1621375_1622773_+	phenylalanine transporter	NA	NA	NA	NA
WP_007370969.1\|1622980_1623850_+	DMT family transporter	NA	NA	NA	NA
WP_144134787.1\|1623838_1624636_-	PhzF family phenazine biosynthesis isomerase	NA	NA	NA	NA
WP_007370971.1\|1624701_1626120_-	MFS transporter	NA	NA	NA	NA
WP_007370972.1\|1626228_1627101_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_007370973.1\|1627075_1627462_-	MmcQ/YjbR family DNA-binding protein	NA	NA	NA	NA
WP_007370974.1\|1627451_1628042_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_079517599.1\|1628234_1629335_+	RomA family MBL fold metallo-hydrolase	NA	NA	NA	NA
WP_007370976.1\|1629373_1629715_+	RamA family antibiotic efflux transcriptional regulator	NA	NA	NA	NA
WP_007370977.1\|1629753_1630146_-	putative DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_035889037.1\|1630147_1630507_-	putative DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_144134791.1\|1631129_1633319_+	EAL domain-containing protein	NA	NA	NA	NA
WP_007370980.1\|1633362_1634550_-	NupC/NupG family nucleoside CNT transporter	NA	NA	NA	NA
WP_035889039.1\|1634904_1636143_+	Mn(2+) uptake NRAMP transporter MntH	NA	NA	NA	NA
WP_007370984.1\|1636219_1636540_-	DUF2502 domain-containing protein	NA	NA	NA	NA
WP_149288482.1\|1636662_1637661_-	L-glyceraldehyde 3-phosphate reductase	NA	NA	NA	NA
WP_149288483.1\|1637841_1639497_+	indolepyruvate decarboxylase	NA	NA	NA	NA
WP_007370987.1\|1639500_1640736_-	ion channel protein	NA	NA	NA	NA
WP_007370988.1\|1640914_1641880_+	glucokinase	NA	NA	NA	NA
WP_007370989.1\|1641876_1642605_-	response regulator transcription factor	A0A2R2ZGH8	Clostridioides_phage	1.9e-14	26.4
WP_090396379.1\|1642617_1644300_-	sensor histidine kinase	NA	NA	NA	NA
WP_007370991.1\|1644687_1645929_+	alanine transaminase	NA	NA	NA	NA
WP_099458783.1\|1645979_1646051_-	membrane protein YpdK	NA	NA	NA	NA
WP_007370992.1\|1646623_1648147_+	histidine ammonia-lyase	A0A1V0S940	Catovirus	5.8e-82	36.9
WP_007370993.1\|1648243_1648891_+	hypothetical protein	NA	NA	NA	NA
WP_007370994.1\|1649475_1649973_+	type VI secretion system contractile sheath small subunit	NA	NA	NA	NA
WP_149288484.1\|1650007_1651555_+	type VI secretion system contractile sheath large subunit	NA	NA	NA	NA
WP_035889045.1\|1651573_1652911_+\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_149288485.1\|1652907_1653561_+	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_149288486.1\|1653660_1655289_+	OmpA family protein	NA	NA	NA	NA
WP_007370999.1\|1655294_1655786_+	Hcp family type VI secretion system effector	NA	NA	NA	NA
WP_149288487.1\|1655953_1658602_+	type VI secretion system ATPase TssH	K4FB40	Cronobacter_phage	1.6e-95	32.9
WP_007371002.1\|1658603_1659209_+	DUF2778 domain-containing protein	NA	NA	NA	NA
WP_007371003.1\|1659205_1659433_+	hypothetical protein	NA	NA	NA	NA
WP_149288488.1\|1659513_1662054_+	type VI secretion system tip protein VgrG	NA	NA	NA	NA
WP_149288489.1\|1662055_1663993_+	lipase family protein	G9E505	Ostreococcus_lucimarinus_virus	5.4e-08	30.0
WP_072440029.1\|1663985_1664753_+	hypothetical protein	NA	NA	NA	NA
WP_083596759.1\|1664967_1665516_+	hypothetical protein	NA	NA	NA	NA
WP_072440031.1\|1665541_1665808_+	PAAR domain-containing protein	NA	NA	NA	NA
WP_149288490.1\|1665811_1666972_+	hypothetical protein	NA	NA	NA	NA
WP_149288491.1\|1666958_1670372_+	type VI secretion protein VasK	NA	NA	NA	NA
WP_071921125.1\|1670371_1671967_+	type VI secretion system protein TssA	NA	NA	NA	NA
WP_149288492.1\|1671987_1673751_+\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_149288493.1\|1673705_1674809_+\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_149288494.1\|1674783_1675326_+	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_007371013.1\|1675318_1675771_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA

DBSCAN-SWA_3

2005751 : 2015089

Enterobacteria_phage(37.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149288580.1\|2005751_2006816_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	7.3e-100	53.1
WP_072439753.1\|2006831_2007707_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.2e-110	68.4
WP_144135070.1\|2007745_2008636_+	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	3.9e-30	33.3
WP_144135068.1\|2008650_2009199_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	1.4e-54	56.1
WP_007371293.1\|2009342_2010749_+	NADP-dependent phosphogluconate dehydrogenase	M4QQM4	Ostreococcus_lucimarinus_virus	2.1e-38	28.3
WP_007371295.1\|2011014_2012181_+	UDP-glucose 6-dehydrogenase	M1HV26	Paramecium_bursaria_Chlorella_virus	1.1e-112	55.0
WP_007371296.1\|2012219_2013224_-	NAD-dependent epimerase	E3T4Y8	Cafeteria_roenbergensis_virus	6.8e-31	29.8
WP_149289354.1\|2013426_2014410_+	LPS O-antigen chain length determinant protein WzzB	NA	NA	NA	NA
WP_007371298.1\|2014477_2015089_-	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE	A0A2H4UVM0	Bodo_saltans_virus	5.8e-17	30.1

DBSCAN-SWA_4

2095604 : 2170425

Escherichia_phage(18.75%)

transposase,tRNA,tail,integrase

attL 2141520:2141579|attR 2172026:2172394

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_149288617.1\|2095604_2096876_-\|integrase	tyrosine-type recombinase/integrase	A0A1B0VMI6	Pseudomonas_phage	4.5e-72	38.9
WP_149288618.1\|2097304_2098753_+	EmmdR/YeeO family multidrug/toxin efflux MATE transporter	NA	NA	NA	NA
WP_149288619.1\|2099089_2100376_+\|integrase	integrase arm-type DNA-binding domain-containing protein	B7SYF8	Stenotrophomonas_phage	8.0e-77	40.5
WP_149288620.1\|2100630_2101858_+\|transposase	IS3 family transposase	Q9ZXG3	Shigella_phage	9.5e-160	90.4
WP_149289356.1\|2101890_2103273_-	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
WP_019843901.1\|2103552_2104209_+	NAD(P)H-binding protein	NA	NA	NA	NA
WP_149288621.1\|2104347_2105467_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	5.1e-51	42.8
WP_019843902.1\|2105902_2106517_+	hypothetical protein	NA	NA	NA	NA
WP_149288622.1\|2106511_2106766_-	hypothetical protein	NA	NA	NA	NA
WP_149288623.1\|2108863_2110429_-	carotenoid oxygenase family protein	NA	NA	NA	NA
WP_072440334.1\|2110438_2111911_-	aldehyde dehydrogenase family protein	NA	NA	NA	NA
WP_149288624.1\|2111907_2113743_-	FUSC family protein	NA	NA	NA	NA
WP_149288625.1\|2113874_2114498_+	TetR family transcriptional regulator	NA	NA	NA	NA
WP_149288626.1\|2114652_2116428_-	M24 family metallopeptidase	A0A0P0I8D7	Acinetobacter_phage	1.6e-75	32.8
WP_149288627.1\|2116444_2117899_-	AMP nucleosidase	NA	NA	NA	NA
WP_107146599.1\|2118029_2119007_-	oxidoreductase	NA	NA	NA	NA
WP_007371377.1\|2119069_2119714_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_007371378.1\|2119872_2120061_-	putative motility protein	NA	NA	NA	NA
WP_107146600.1\|2121348_2122173_+	mannosyl-3-phosphoglycerate phosphatase-related protein	NA	NA	NA	NA
WP_007371381.1\|2122169_2123390_+	hypothetical protein	NA	NA	NA	NA
WP_149288628.1\|2123631_2124975_-	allantoin permease	NA	NA	NA	NA
WP_149288629.1\|2125033_2126014_-	5-oxoprolinase/urea amidolyase family protein	NA	NA	NA	NA
WP_072440321.1\|2125994_2126885_-	allophanate hydrolase subunit 1	NA	NA	NA	NA
WP_079517730.1\|2126874_2128275_-	acetyl-CoA carboxylase biotin carboxylase subunit	NA	NA	NA	NA
WP_007371386.1\|2128291_2128543_-	biotin carboxyl carrier domain-containing protein	NA	NA	NA	NA
WP_007371387.1\|2128572_2129337_-	5-oxoprolinase subunit PxpA	NA	NA	NA	NA
WP_149288630.1\|2129481_2130399_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_007371389.1\|2131375_2132293_+	nitrogen assimilation transcriptional regulator	NA	NA	NA	NA
WP_007371390.1\|2132394_2133345_+	HTH-type transcriptional regulator Cbl	NA	NA	NA	NA
WP_149288631.1\|2133599_2133809_+	hypothetical protein	NA	NA	NA	NA
WP_149288632.1\|2133769_2135299_+	AAA family ATPase	NA	NA	NA	NA
WP_149288633.1\|2135288_2136308_+	hypothetical protein	NA	NA	NA	NA
WP_149288634.1\|2136369_2137698_-	shikimate transporter	NA	NA	NA	NA
WP_107146604.1\|2137762_2138014_-	hypothetical protein	NA	NA	NA	NA
WP_007371396.1\|2138548_2139175_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_007371397.1\|2139230_2140388_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
2141520:2141579	attL	NA	NA	NA	NA
WP_149288635.1\|2142501_2142792_-	metal-sensing transcriptional repressor	NA	NA	NA	NA
WP_149288636.1\|2142857_2143367_-	transcriptional repressor	NA	NA	NA	NA
WP_149288637.1\|2143521_2143941_+	phosphoribosyl-AMP cyclohydrolase	NA	NA	NA	NA
WP_149288638.1\|2143963_2145187_+	GTP-binding protein	NA	NA	NA	NA
WP_149288639.1\|2145226_2145439_-	hypothetical protein	NA	NA	NA	NA
WP_149288640.1\|2145441_2146485_-	ferrous iron transporter B	NA	NA	NA	NA
WP_149288264.1\|2146557_2147340_-	ATP-binding protein	A0A2L1IVB6	Escherichia_phage	3.9e-135	96.1
WP_149288265.1\|2147336_2148359_-\|transposase	IS21-like element ISSen3 family transposase	A0A2L1IVA1	Escherichia_phage	1.5e-174	85.3
WP_149288641.1\|2148422_2149052_-	hypothetical protein	NA	NA	NA	NA
WP_149288642.1\|2149062_2150193_-	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_149288643.1\|2150268_2151651_-\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	3.9e-45	29.5
WP_149289357.1\|2151739_2152135_-	transcriptional repressor	NA	NA	NA	NA
WP_149288644.1\|2152293_2153493_+	cobalamin biosynthesis protein CobW	NA	NA	NA	NA
WP_149288645.1\|2153562_2153985_+	RNA polymerase-binding protein DksA	NA	NA	NA	NA
WP_149289358.1\|2154088_2154988_+	GTP cyclohydrolase I FolE2	NA	NA	NA	NA
WP_149288646.1\|2154977_2155538_+	carbonate dehydratase	NA	NA	NA	NA
WP_149288647.1\|2155666_2156533_+	isocitrate dehydrogenase	NA	NA	NA	NA
WP_149288648.1\|2156703_2158656_+\|tRNA	threonine--tRNA ligase	A0A2K9L6B6	Tupanvirus	1.6e-121	36.9
WP_149288649.1\|2158648_2159500_+	M14 family metallocarboxypeptidase	NA	NA	NA	NA
WP_149288650.1\|2159496_2160843_+	dihydroorotase	NA	NA	NA	NA
WP_007371403.1\|2161831_2162629_-	DgsA anti-repressor MtfA	NA	NA	NA	NA
WP_149288651.1\|2162892_2163789_-\|integrase	tyrosine-type recombinase/integrase	A0A192Y7M7	Salmonella_phage	2.7e-87	56.8
WP_007371405.1\|2163853_2164138_-	DUF4224 domain-containing protein	NA	NA	NA	NA
WP_149288652.1\|2165901_2166141_+	hypothetical protein	K7PHG9	Enterobacteria_phage	2.7e-10	50.8
WP_149288653.1\|2166262_2166457_+	hypothetical protein	H6WRY8	Salmonella_phage	2.5e-14	58.7
WP_149288654.1\|2166453_2166822_+	RusA family crossover junction endodeoxyribonuclease	K7P6W0	Enterobacteria_phage	1.3e-40	64.0
WP_149288655.1\|2166806_2167859_+	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	6.7e-106	54.3
WP_149288656.1\|2167871_2168492_+	hypothetical protein	H9C175	Pectobacterium_phage	1.7e-61	54.7
WP_149288657.1\|2168810_2169140_-	hypothetical protein	NA	NA	NA	NA
WP_149289359.1\|2169249_2169432_-	hypothetical protein	NA	NA	NA	NA
WP_149288658.1\|2170026_2170425_+\|tail	tail fiber domain-containing protein	K7PGY2	Enterobacteria_phage	4.8e-20	57.8
2172026:2172394	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2398895 : 2465837

Tupanvirus(25.0%)

plate,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035887401.1\|2398895_2399465_+\|plate	type VI secretion system baseplate subunit TssE	NA	NA	NA	NA
WP_007371688.1\|2399467_2401339_+\|plate	type VI secretion system baseplate subunit TssF	NA	NA	NA	NA
WP_149288692.1\|2401335_2402379_+\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA
WP_149288693.1\|2402423_2405036_+	type VI secretion system ATPase TssH	A0A248SJW6	Salicola_phage	6.4e-81	31.1
WP_007371691.1\|2405062_2406499_+	protein kinase	M1HXR9	Acanthocystis_turfacea_Chlorella_virus	3.6e-09	27.3
WP_035887397.1\|2406648_2407029_+	DcrB-related protein	NA	NA	NA	NA
WP_149288694.1\|2407087_2409013_+	type VI secretion system tip protein VgrG	A0A077K8Q4	Ralstonia_phage	6.4e-46	28.9
WP_149288695.1\|2409025_2409832_+	DcrB-related protein	NA	NA	NA	NA
WP_149288696.1\|2409824_2411156_+	hypothetical protein	NA	NA	NA	NA
WP_090396665.1\|2411155_2412226_+	ADP-ribosylglycohydrolase	A0A1S6UB21	Serratia_phage	4.7e-54	41.6
WP_149288697.1\|2412646_2413033_+	hypothetical protein	NA	NA	NA	NA
WP_149288698.1\|2413389_2413650_+	hypothetical protein	NA	NA	NA	NA
WP_007371712.1\|2413947_2415597_-	fumarate hydratase	NA	NA	NA	NA
WP_007371713.1\|2415648_2417160_-	anion permease	NA	NA	NA	NA
WP_149288699.1\|2417796_2420574_+	flavocytochrome c	A0A2P0ZL82	Lactobacillus_phage	1.1e-70	32.1
WP_064565802.1\|2420737_2421700_+	FAD:protein FMN transferase	NA	NA	NA	NA
WP_007371716.1\|2421680_2422400_-	two-component system response regulator DcuR	NA	NA	NA	NA
WP_107146668.1\|2422396_2424013_-	two-component system sensor histidine kinase DcuS	NA	NA	NA	NA
WP_035887378.1\|2424189_2425104_+	N-acetylmuramic acid 6-phosphate etherase	NA	NA	NA	NA
WP_007371719.1\|2425385_2427038_+	malate dehydrogenase (quinone)	NA	NA	NA	NA
WP_035887374.1\|2427078_2428428_-	MFS transporter	NA	NA	NA	NA
WP_007371723.1\|2428838_2429537_+	glutamine amidotransferase	A0A2K9L2L9	Tupanvirus	7.3e-08	26.7
WP_035888626.1\|2429764_2430592_+	nitrogenase iron protein	NA	NA	NA	NA
WP_007371726.1\|2430636_2432208_+	nitrogenase iron-iron protein, alpha chain	NA	NA	NA	NA
WP_007371727.1\|2432204_2432549_+	Fe-only nitrogenase subunit delta	NA	NA	NA	NA
WP_149288700.1\|2432560_2433949_+	Fe-only nitrogenase subunit beta	NA	NA	NA	NA
WP_035888623.1\|2433992_2434415_+	hypothetical protein	NA	NA	NA	NA
WP_035888621.1\|2434411_2434906_+	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
WP_149288701.1\|2434918_2435530_+	hypothetical protein	NA	NA	NA	NA
WP_083566005.1\|2435710_2437315_+	GAF domain-containing protein	NA	NA	NA	NA
WP_007371733.1\|2437742_2438615_+\|protease	serine protease	NA	NA	NA	NA
WP_071920934.1\|2438646_2440383_-	sigma-54-dependent Fis family transcriptional regulator	NA	NA	NA	NA
WP_007371735.1\|2440656_2442177_+	aldehyde dehydrogenase	NA	NA	NA	NA
WP_079517798.1\|2442204_2443236_+	alcohol dehydrogenase AdhP	A0A2K9L339	Tupanvirus	8.0e-35	28.1
WP_071920933.1\|2443277_2444162_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_007371738.1\|2444245_2444599_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_035888616.1\|2444639_2445650_-	type I glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
WP_090396681.1\|2445728_2446709_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_007371742.1\|2446886_2447096_+	hypothetical protein	NA	NA	NA	NA
WP_035888614.1\|2447441_2449625_-	catalase/peroxidase HPI	NA	NA	NA	NA
WP_007371744.1\|2449946_2450735_-	hypothetical protein	NA	NA	NA	NA
WP_149288702.1\|2451277_2451832_-	hypothetical protein	NA	NA	NA	NA
WP_149288703.1\|2452353_2454864_-	type VI secretion system ATPase TssH	K4FB40	Cronobacter_phage	2.3e-83	34.1
WP_149288704.1\|2454883_2458312_-	hypothetical protein	NA	NA	NA	NA
WP_007371748.1\|2458318_2458939_-	DotU family type IV/VI secretion system protein	NA	NA	NA	NA
WP_007371749.1\|2458935_2460297_-\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
WP_072439907.1\|2460298_2460928_-	type VI secretion system lipoprotein TssJ	NA	NA	NA	NA
WP_071920930.1\|2460927_2461980_-	type VI secretion system protein TssA	NA	NA	NA	NA
WP_035888596.1\|2461986_2462286_-	type VI secretion protein	NA	NA	NA	NA
WP_007371753.1\|2462285_2462732_-	hypothetical protein	NA	NA	NA	NA
WP_149288705.1\|2462742_2464881_-	type VI secretion system tip protein VgrG	NA	NA	NA	NA
WP_149288706.1\|2464895_2465837_-\|plate	type VI secretion system baseplate subunit TssG	NA	NA	NA	NA

DBSCAN-SWA_6

4070053 : 4078184

uncultured_Caudovirales_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_007373725.1\|4070053_4070308_+	DUF1471 domain-containing protein	A0A1B2IB27	Erwinia_phage	6.1e-05	49.1
WP_007373724.1\|4070411_4070768_+	helix-turn-helix domain-containing protein	D0R0F8	Streptococcus_phage	3.2e-07	36.9
WP_090397363.1\|4071011_4071350_+	hypothetical protein	NA	NA	NA	NA
WP_007373721.1\|4071633_4072761_+	porin OmpC	Q1MVN1	Enterobacteria_phage	8.5e-99	51.3
WP_007373720.1\|4072971_4073226_+	DUF1471 domain-containing protein	A0A1B2ICL8	Erwinia_phage	9.4e-06	49.1
WP_072438322.1\|4073312_4073738_-	glutaredoxin-dependent arsenate reductase	A0A2H4J8T1	uncultured_Caudovirales_phage	8.6e-52	71.4
WP_007373718.1\|4073750_4075040_-	arsenic transporter	A0A2H4J144	uncultured_Caudovirales_phage	2.0e-168	72.3
WP_007373717.1\|4075083_4075404_-	metalloregulator ArsR/SmtB family transcription factor	A0A2H4J145	uncultured_Caudovirales_phage	7.7e-21	48.0
WP_007373716.1\|4075578_4076985_-	heavy metal sensor histidine kinase	NA	NA	NA	NA
WP_007373715.1\|4076996_4077689_-	heavy metal response regulator transcription factor	W8CYM9	Bacillus_phage	5.5e-32	34.2
WP_007373714.1\|4077851_4078184_-	helix-turn-helix domain-containing protein	D0R0F8	Streptococcus_phage	6.1e-05	29.5

DBSCAN-SWA_7

4142838 : 4215831

Enterobacteria_phage(32.56%)

plate,tail,protease,portal,tRNA,terminase,integrase,capsid,head

attL 4178355:4178374|attR 4211799:4211818

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_035889769.1\|4142838_4143726_+\|tail	tail fiber protein	E3T4R8	Cafeteria_roenbergensis_virus	2.0e-10	35.4
WP_149289048.1\|4143830_4149767_+	DUF4347 domain-containing protein	NA	NA	NA	NA
WP_007373639.1\|4149864_4151373_+	TolC family protein	NA	NA	NA	NA
WP_007373630.1\|4152991_4153858_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD	A0A249XZQ2	Enterococcus_phage	3.8e-30	36.2
WP_007373629.1\|4153859_4154072_+	ribosome-associated protein YbcJ	NA	NA	NA	NA
WP_071920392.1\|4154358_4155858_+	PTS transporter subunit EIIC	NA	NA	NA	NA
WP_007373627.1\|4155939_4156956_+	Mal regulon transcriptional regulator MalI	NA	NA	NA	NA
WP_043954539.1\|4157184_4157706_+	metal-dependent hydrolase	NA	NA	NA	NA
WP_035887331.1\|4157831_4159217_-\|tRNA	cysteine--tRNA ligase	A0A2K9L6B7	Tupanvirus	1.4e-42	33.2
WP_007373624.1\|4159390_4159885_+	peptidylprolyl isomerase B	NA	NA	NA	NA
WP_149289049.1\|4159887_4160610_+	UDP-2,3-diacylglucosamine diphosphatase	NA	NA	NA	NA
WP_149289050.1\|4160699_4161533_+	hypothetical protein	NA	NA	NA	NA
WP_149289051.1\|4161529_4162471_+	DUF1848 family protein	NA	NA	NA	NA
WP_007373622.1\|4162588_4163098_+	5-(carboxyamino)imidazole ribonucleotide mutase	NA	NA	NA	NA
WP_007373621.1\|4163094_4164162_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_144134252.1\|4164260_4164809_-	hypothetical protein	NA	NA	NA	NA
WP_149289052.1\|4165147_4166233_+\|tRNA	tRNA 2-selenouridine(34) synthase MnmH	NA	NA	NA	NA
WP_149289053.1\|4166304_4166964_-	ABC transporter permease subunit	NA	NA	NA	NA
WP_007373617.1\|4166956_4167979_-	virulence-associated ABC transporter ATP-binding protein SfbB	A0A1V0SGN0	Hokovirus	5.7e-09	28.1
WP_149289054.1\|4168036_4168873_-	metal ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_149289055.1\|4169174_4170326_-	autotransporter domain-containing protein	NA	NA	NA	NA
WP_149289056.1\|4170522_4172937_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_149289057.1\|4172933_4173620_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.3e-06	27.7
WP_007373612.1\|4173590_4174214_+\|protease	multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1	NA	NA	NA	NA
WP_007373611.1\|4174243_4175014_+	SDR family oxidoreductase	NA	NA	NA	NA
WP_007373610.1\|4175076_4175931_+	co-chaperone YbbN	NA	NA	NA	NA
WP_035887325.1\|4176015_4176933_+	SPFH/Band 7/PHB domain protein	NA	NA	NA	NA
WP_007373608.1\|4176929_4177388_+	NfeD family protein	NA	NA	NA	NA
WP_007373607.1\|4177391_4177799_-	Cu(I)-responsive transcriptional regulator	NA	NA	NA	NA
WP_007373606.1\|4177970_4178267_+	NINE protein	M4ZS56	Bacillus_phage	1.8e-16	65.6
4178355:4178374	attL	NA	NA	NA	NA
WP_074776716.1\|4178432_4179455_-\|integrase	tyrosine-type recombinase/integrase	A0A0F7LA05	Escherichia_phage	8.3e-93	48.6
WP_074776715.1\|4179524_4179824_-	helix-turn-helix transcriptional regulator	Q1JS29	Enterobacteria_phage	1.2e-31	65.7
WP_149289058.1\|4179949_4180168_+	hypothetical protein	NA	NA	NA	NA
WP_074776713.1\|4180172_4180436_-	hypothetical protein	NA	NA	NA	NA
WP_074776712.1\|4180434_4180668_+	hypothetical protein	NA	NA	NA	NA
WP_071921834.1\|4180881_4181217_+	hypothetical protein	NA	NA	NA	NA
WP_074776711.1\|4181249_4181453_+	DUF4761 family protein	A0A0M5M1I3	Salmonella_phage	8.9e-23	75.4
WP_149289059.1\|4181442_4181673_+	DUF2724 domain-containing protein	A0A0M4S6M9	Salmonella_phage	2.6e-31	78.9
WP_074776709.1\|4181757_4181964_+	hypothetical protein	A0A0M4R514	Salmonella_phage	4.0e-15	57.8
WP_074776708.1\|4181968_4182208_+	DUF2732 family protein	A0A1S6L021	Salmonella_phage	1.3e-09	50.7
WP_149289060.1\|4182207_4182426_+	TraR/DksA family transcriptional regulator	A0A0M4S5Q7	Salmonella_phage	7.5e-20	63.9
WP_149289377.1\|4182432_4183296_+	Dam family site-specific DNA-(adenine-N6)-methyltransferase	E5G6L8	Salmonella_phage	2.8e-102	64.6
WP_149289061.1\|4183327_4185778_+	replication endonuclease	F1BUS0	Erwinia_phage	8.8e-141	38.5
WP_149289062.1\|4185931_4186633_+	DNA adenine methylase	A0A0M4S5U3	Salmonella_phage	7.4e-93	72.6
WP_149289063.1\|4186697_4186970_-	hypothetical protein	NA	NA	NA	NA
WP_149289064.1\|4186953_4187499_-	DUF2778 domain-containing protein	NA	NA	NA	NA
WP_149289065.1\|4187652_4188156_-	DUF4760 domain-containing protein	NA	NA	NA	NA
WP_149289066.1\|4188826_4189879_-\|portal	phage portal protein	A0A0A7NPT9	Enterobacteria_phage	8.1e-144	69.7
WP_079518311.1\|4189881_4191603_-	oxidoreductase	A0A0A7NV54	Enterobacteria_phage	5.6e-227	66.3
WP_071920372.1\|4191762_4192596_+\|capsid	GPO family capsid scaffolding protein	B9A7B4	Serratia_phage	2.3e-101	66.8
WP_071920371.1\|4192619_4193669_+\|capsid	phage major capsid protein, P2 family	A0A0M3ULA3	Salmonella_phage	2.7e-107	55.4
WP_149289067.1\|4193717_4194626_+\|terminase	terminase	B9A7B6	Serratia_phage	2.3e-86	74.0
WP_149289068.1\|4194728_4195226_+\|head	head completion/stabilization protein	B9A7B7	Serratia_phage	6.9e-61	70.9
WP_149289069.1\|4195225_4195426_+\|tail	phage tail protein	A0A0A7NV57	Enterobacteria_phage	8.7e-15	63.1
WP_149289070.1\|4195477_4195780_+	hypothetical protein	O64361	Escherichia_phage	1.6e-31	67.3
WP_090137603.1\|4195779_4196265_+	lysozyme	A0A1R3Y5W5	Salmonella_virus	3.5e-49	56.9
WP_149289071.1\|4196261_4196825_+	hypothetical protein	K7PHH7	Enterobacteria_phage	9.0e-41	55.8
WP_149289072.1\|4196821_4197283_+\|tail	phage tail protein	A0A0A7NPU6	Enterobacteria_phage	3.9e-34	50.0
WP_149289073.1\|4197279_4197921_+	phage virion morphogenesis protein	A0A0A7NV60	Enterobacteria_phage	6.2e-46	50.0
WP_149289074.1\|4197920_4198505_+\|plate	phage baseplate assembly protein V	A0A0A7NRZ3	Enterobacteria_phage	5.1e-63	63.0
WP_149289075.1\|4198501_4198870_+\|plate	baseplate assembly protein	A0A0A7NQ90	Enterobacteria_phage	2.7e-33	62.6
WP_149289076.1\|4198856_4199753_+\|plate	baseplate assembly protein	A0A0A7NPY5	Enterobacteria_phage	7.8e-103	67.4
WP_071920359.1\|4199745_4200354_+\|tail	phage tail protein I	A0A218M4J3	Erwinia_phage	1.5e-70	64.4
WP_149289077.1\|4200350_4201661_+\|tail	phage tail protein	M1TAS6	Escherichia_phage	1.2e-149	58.0
WP_149289078.1\|4201660_4202251_+\|tail	tail fiber assembly protein	M1SV83	Escherichia_phage	1.4e-47	53.1
WP_149289079.1\|4202381_4203488_+	LPS O-antigen length regulator	NA	NA	NA	NA
WP_149289080.1\|4203910_4204399_-\|tail	phage tail protein	A0A0A7NV65	Enterobacteria_phage	8.1e-54	62.3
WP_149289081.1\|4204410_4207374_-\|tail	phage tail tape measure protein	A0A0A7NRZ9	Enterobacteria_phage	4.3e-190	41.9
WP_143468281.1\|4207354_4207525_-\|tail	GpE family phage tail protein	O80316	Escherichia_phage	7.9e-09	59.1
WP_074776683.1\|4207521_4207821_-\|tail	phage tail assembly protein	B9A7B2	Serratia_phage	2.8e-33	75.8
WP_071920348.1\|4207877_4208393_-\|tail	phage major tail tube protein	A0A0A7NPV8	Enterobacteria_phage	1.2e-52	60.4
WP_090137616.1\|4208393_4209575_-\|tail	phage tail protein	A0A0A7NV69	Enterobacteria_phage	3.7e-153	67.8
WP_149289082.1\|4209725_4210877_+	phage late control D family protein	B9A7A9	Serratia_phage	6.3e-174	78.6
WP_149289083.1\|4210925_4211174_+	ogr/Delta-like zinc finger family protein	NA	NA	NA	NA
WP_149289084.1\|4211211_4211601_-	hypothetical protein	B9A7A8	Serratia_phage	2.7e-36	55.8
WP_149289085.1\|4211874_4214373_+	copper-exporting P-type ATPase CopA	A0A218MNH6	uncultured_virus	1.1e-111	38.0
4211799:4211818	attR	NA	NA	NA	NA
WP_144134244.1\|4214462_4215272_+	conjugal transfer protein TraB	NA	NA	NA	NA
WP_007373603.1\|4215351_4215831_+\|tRNA	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	NA	NA	NA	NA

DBSCAN-SWA_8

5489985 : 5585109

Escherichia_phage(42.86%)

plate,tRNA,protease,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_071921770.1\|5489985_5491086_+\|tRNA	tRNA (uridine(54)-C5)-methyltransferase TrmA	NA	NA	NA	NA
WP_007369204.1\|5491123_5491489_-	YijD family membrane protein	NA	NA	NA	NA
WP_035889190.1\|5491488_5492142_-	HTH-type transcriptional repressor FabR	NA	NA	NA	NA
WP_035889188.1\|5492337_5493738_+	Si-specific NAD(P)(+) transhydrogenase	NA	NA	NA	NA
WP_007369207.1\|5493720_5494638_-	DNA-binding transcriptional regulator OxyR	NA	NA	NA	NA
WP_007369208.1\|5494898_5496272_-	argininosuccinate lyase	NA	NA	NA	NA
WP_090398622.1\|5496389_5497166_-	acetylglutamate kinase	NA	NA	NA	NA
WP_007369210.1\|5497176_5498181_-	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
WP_035889183.1\|5498349_5499501_+	acetylornithine deacetylase	NA	NA	NA	NA
WP_035889182.1\|5499765_5502417_+	phosphoenolpyruvate carboxylase	NA	NA	NA	NA
WP_007369213.1\|5502511_5503363_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_071921769.1\|5503580_5504243_+	fructose-6-phosphate aldolase	M4SLG0	Cyanophage	1.9e-29	34.4
WP_007369215.1\|5504254_5505358_+	glycerol dehydrogenase	NA	NA	NA	NA
WP_071921768.1\|5505443_5506334_-	methylenetetrahydrofolate reductase	NA	NA	NA	NA
WP_007369218.1\|5506539_5508972_-	bifunctional aspartate kinase/homoserine dehydrogenase II	NA	NA	NA	NA
WP_007369219.1\|5508974_5510135_-	cystathionine gamma-synthase	NA	NA	NA	NA
WP_007369220.1\|5510398_5510716_+	met regulon transcriptional regulator MetJ	NA	NA	NA	NA
WP_139201294.1\|5510774_5510984_-	hypothetical protein	NA	NA	NA	NA
WP_007369223.1\|5511019_5511232_-	50S ribosomal protein L31	NA	NA	NA	NA
WP_071921767.1\|5511439_5513632_+	primosomal protein N'	NA	NA	NA	NA
WP_149289300.1\|5513756_5514782_+	DNA-binding transcriptional regulator CytR	NA	NA	NA	NA
WP_035889181.1\|5514875_5515877_+	cell division protein FtsN	NA	NA	NA	NA
WP_007369227.1\|5515969_5516500_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_079517135.1\|5516509_5517841_+	HslU--HslV peptidase ATPase subunit	W6AS21	Erwinia_phage	5.4e-44	29.7
WP_035889179.1\|5517907_5518837_+	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
WP_007369230.1\|5518929_5519415_+	ribonuclease E activity regulator RraA	NA	NA	NA	NA
WP_007369231.1\|5519587_5519833_-	septal ring assembly protein ZapB	NA	NA	NA	NA
WP_149289301.1\|5520259_5521108_+	MIP family channel protein	M1HWZ0	Paramecium_bursaria_Chlorella_virus	4.4e-15	28.7
WP_149289302.1\|5521129_5522638_+	glycerol kinase GlpK	NA	NA	NA	NA
WP_007369234.1\|5522739_5523750_+	class II fructose-bisphosphatase	NA	NA	NA	NA
WP_007369235.1\|5523846_5524593_+	ferredoxin--NADP(+) reductase	NA	NA	NA	NA
WP_007369236.1\|5524593_5525013_-	DUF805 domain-containing protein	NA	NA	NA	NA
WP_007369237.1\|5525125_5525725_+	YiiQ family protein	NA	NA	NA	NA
WP_007369238.1\|5525832_5526600_+	triose-phosphate isomerase	NA	NA	NA	NA
WP_072441548.1\|5526740_5528045_-	citrate transporter	NA	NA	NA	NA
WP_007369240.1\|5528118_5528877_-	CDP-diacylglycerol diphosphatase	NA	NA	NA	NA
WP_149289303.1\|5529001_5529991_-	sulfate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_007369242.1\|5530139_5531102_-	6-phosphofructokinase	NA	NA	NA	NA
WP_071921762.1\|5531301_5532186_-	CDF family cation-efflux transporter FieF	NA	NA	NA	NA
WP_072441551.1\|5532382_5532607_-	DUF2188 domain-containing protein	NA	NA	NA	NA
WP_149289392.1\|5532947_5533166_-	DNA-binding transcriptional regulator	S4TNZ3	Salmonella_phage	3.0e-32	87.5
WP_149289304.1\|5534395_5534872_-\|tail	phage tail protein	O64315	Escherichia_phage	1.3e-61	72.6
WP_149289305.1\|5534887_5537329_-\|tail	phage tail tape measure protein	S4TP64	Salmonella_phage	3.5e-246	70.7
WP_071531957.1\|5537321_5537441_-\|tail	GpE family phage tail protein	A0A0F7LCR6	Escherichia_phage	3.3e-14	87.2
WP_007370054.1\|5537473_5537749_-\|tail	phage tail assembly protein	A0A0F7LDQ8	Escherichia_phage	3.3e-36	86.8
WP_007370053.1\|5537810_5538329_-\|tail	phage major tail tube protein	A0A0F7LDZ1	Escherichia_phage	1.8e-88	91.9
WP_149289306.1\|5538341_5539532_-\|tail	phage tail sheath protein	A0A0F7LBW9	Escherichia_phage	3.0e-203	88.9
WP_144136388.1\|5539802_5540657_+	benzoate transporter	A0A0N9QAD0	Chrysochromulina_ericina_virus	6.6e-27	32.5
WP_072441519.1\|5540681_5541188_-\|tail	phage tail protein	A0A1S6KZZ1	Salmonella_phage	8.5e-14	30.6
WP_149289307.1\|5541190_5542756_-\|tail	phage tail protein	S4TP62	Salmonella_phage	1.7e-89	78.0
WP_149289308.1\|5542766_5543297_-\|tail	phage tail protein I	Q37841	Escherichia_phage	3.8e-89	85.7
WP_149289309.1\|5543289_5544198_-\|plate	baseplate assembly protein	A0A0F7LCJ3	Escherichia_phage	6.0e-135	81.1
WP_149289310.1\|5544202_5544547_-\|plate	baseplate assembly protein	A0A0F7LDQ1	Escherichia_phage	8.8e-39	69.6
WP_149289311.1\|5545278_5545821_+	hypothetical protein	NA	NA	NA	NA
WP_149289312.1\|5545817_5546219_+	hypothetical protein	NA	NA	NA	NA
WP_149289393.1\|5547282_5547777_-	cell-envelope stress modulator CpxP	NA	NA	NA	NA
WP_035889119.1\|5547928_5548627_+	envelope stress response regulator transcription factor CpxR	Q6XM27	Feldmannia_irregularis_virus	3.1e-06	30.3
WP_007369293.1\|5548623_5549997_+	envelope stress sensor histidine kinase CpxA	W8CYF6	Bacillus_phage	4.2e-15	24.1
WP_007369294.1\|5550028_5550703_-	6-N-hydroxylaminopurine resistance protein	NA	NA	NA	NA
WP_035889202.1\|5550863_5551757_+	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
WP_007369296.1\|5551832_5552816_-	2-keto-3-deoxygluconate transporter	NA	NA	NA	NA
WP_007369297.1\|5553074_5553695_-	superoxide dismutase [Mn]	Q56AR7	Bacillus_thuringiensis_phage	5.4e-63	58.9
WP_035889113.1\|5553984_5555019_+	L-rhamnose/proton symporter RhaT	NA	NA	NA	NA
WP_107147506.1\|5555019_5555868_-	HTH-type transcriptional activator RhaR	NA	NA	NA	NA
WP_072441494.1\|5555941_5556778_-	HTH-type transcriptional activator RhaS	NA	NA	NA	NA
WP_107147508.1\|5556837_5556921_-	ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_149289313.1\|5557077_5558547_+	rhamnulokinase	NA	NA	NA	NA
WP_149289314.1\|5558543_5559803_+	L-rhamnose isomerase	NA	NA	NA	NA
WP_007369303.1\|5559951_5560782_+	rhamnulose-1-phosphate aldolase	NA	NA	NA	NA
WP_072441486.1\|5560906_5561893_+	rhamnose ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_149289315.1\|5561944_5563456_+	ATP-binding cassette domain-containing protein	A0A2H4PQG7	Staphylococcus_phage	1.5e-18	29.4
WP_107147516.1\|5563455_5564460_+	ABC transporter permease	NA	NA	NA	NA
WP_071921752.1\|5564456_5565461_+	ABC transporter permease	NA	NA	NA	NA
WP_007369309.1\|5565586_5566735_+	lactaldehyde reductase	NA	NA	NA	NA
WP_007369310.1\|5566731_5567046_+	L-rhamnose mutarotase	NA	NA	NA	NA
WP_007369311.1\|5567079_5567820_-	molecular chaperone	NA	NA	NA	NA
WP_007369312.1\|5567816_5569136_-	fimbrial protein	NA	NA	NA	NA
WP_007369313.1\|5569151_5571677_-	fimbrial biogenesis outer membrane usher protein	NA	NA	NA	NA
WP_072441477.1\|5571725_5572448_-	molecular chaperone	NA	NA	NA	NA
WP_051644045.1\|5572494_5573034_-	type 1 fimbrial protein	NA	NA	NA	NA
WP_007369317.1\|5573463_5574012_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_035889098.1\|5574115_5574778_+	AzlC family ABC transporter permease	NA	NA	NA	NA
WP_007369319.1\|5574777_5575101_+	AzlD domain-containing protein	NA	NA	NA	NA
WP_007369320.1\|5575141_5575354_-	DUF1471 domain-containing protein	NA	NA	NA	NA
WP_007369321.1\|5575468_5576308_-	formate dehydrogenase accessory sulfurtransferase FdhD	NA	NA	NA	NA
WP_139201295.1\|5576547_5579598_+	formate dehydrogenase-N subunit alpha	A0A077SK27	Escherichia_phage	2.1e-06	23.4
WP_035890345.1\|5579610_5580513_+	formate dehydrogenase subunit beta	NA	NA	NA	NA
WP_007369325.1\|5580509_5581145_+	formate dehydrogenase cytochrome b556 subunit	NA	NA	NA	NA
WP_007369326.1\|5581141_5582071_+	formate dehydrogenase accessory protein FdhE	NA	NA	NA	NA
WP_035890346.1\|5582370_5583282_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_035890347.1\|5583299_5583638_+	steroid Delta-isomerase	NA	NA	NA	NA
WP_090398653.1\|5583685_5584675_-	fatty acid biosynthesis protein FabY	NA	NA	NA	NA
WP_007369330.1\|5584671_5585109_-\|tRNA	D-tyrosyl-tRNA(Tyr) deacylase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP040393

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP040392

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection