CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP043612	Flavobacterium nitrogenifigens strain KACC 18538 chromosome, complete genome	11 crisprs	DEDDh,PD-DExK,cas3,csa3,WYL,RT	0	6	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP043612_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_1

737691-737785

Orphan

Consensus_repeat	Method
AAAAGCCTAAAGCTTAAAGCCTACTGCGTAAAGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_1

>merge|NZ_CP043612|1|737691-737785|CRISPRCasFinder
AAAAGCCTAAAGCTTAAAGCCTACTGCGTAAAGCATAAAAAAATTATTAACAGCAGTAGAAAAAGCCTAAAGCTTAAAGCCTACTGCCTAAAGCA

>NZ_CP043612|1|1|737691-737785|CRISPRCasFinder
AAAAGCCTAAAGCTTAAAGCCTACTGCGTAAAGCA	TAAAAAAATTATTAACAGCAGTAGA
AAAAGCCTAAAGCTTAAAGCCTACTGCCTAAAGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111377312.1\|727817_730346_-\|type-I-DNA-topoisomerase	unknown	unknown	gnl\|CDD\|236048
NZ_CP043612.1\|WP_149229128.1\|749426_750080_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377419.1\|737282_737639_+\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|319869
NZ_CP043612.1\|WP_111365084.1\|736431_736776_+\|preprotein-translocase-subunit-SecG	unknown	unknown	gnl\|CDD\|377143
NZ_CP043612.1\|WP_111377314.1\|725000_726395_-\|gliding-motility-lipoprotein-GldK	unknown	unknown	gnl\|CDD\|274629
NZ_CP043612.1\|WP_142479111.1\|747495_748260_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377306.1\|739749_740949_+\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|293742
NZ_CP043612.1\|WP_111377305.1\|741312_742842_-\|SulP-family-inorganic-anion-transporter	unknown	unknown	gnl\|CDD\|223732
NZ_CP043612.1\|WP_111377304.1\|743066_743462_-\|peptidase-S24	unknown	unknown	unknown
NZ_CP043612.1\|WP_142479110.1\|745298_746396_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377313.1\|726657_727809_-\|formimidoylglutamase	unknown	unknown	gnl\|CDD\|212514
NZ_CP043612.1\|WP_111377309.1\|732752_734012_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP043612.1\|WP_111377308.1\|734112_734616_+\|lipoprotein	unknown	unknown	gnl\|CDD\|377341
NZ_CP043612.1\|WP_111377299.1\|748391_749201_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377303.1\|743552_743759_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235089
NZ_CP043612.1\|WP_111377310.1\|732250_732622_+\|GxxExxY-protein	unknown	unknown	gnl\|CDD\|275083
NZ_CP043612.1\|WP_111377302.1\|743799_744954_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377307.1\|737794_739426_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
NZ_CP043612.1\|WP_008467105.1\|736920_737196_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
NZ_CP043612.1\|WP_111377311.1\|730717_732163_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237676

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111377312.1\|727817_730346_-\|type-I-DNA-topoisomerase	gnl\|CDD\|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NZ_CP043612.1\|WP_111377419.1\|737282_737639_+\|four-helix-bundle-protein	gnl\|CDD\|319869	cd16377, 23S_rRNA_IVP_like, 23S rRNA-intervening sequence protein and similar proteins. A family of functionally uncharacterized bacterial proteins, some of which are encoded by an atypically large intervening sequence present within some 23S rRNA genes. The distantly related bAvd protein, which also forms a homopentamer of four-helix bundles, has been suggested to interact with nucleic acids and a reverse transcriptase.	1.20567e-49
NZ_CP043612.1\|WP_111365084.1\|736431_736776_+\|preprotein-translocase-subunit-SecG	gnl\|CDD\|377143	pfam03840, SecG, Preprotein translocase SecG subunit.	2.35772e-13
NZ_CP043612.1\|WP_111377314.1\|725000_726395_-\|gliding-motility-lipoprotein-GldK	gnl\|CDD\|274629	TIGR03525, lipoprotein_putative, gliding motility-associated lipoprotein GldK. Members of this protein family are exclusive to the Bacteroidetes phylum (previously Cytophaga-Flavobacteria-Bacteroides). GldK is a lipoprotein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae. Knockouts of GldK abolish the gliding phenotype. GldK is homologous to GldJ. There is a GldK homolog in Cytophaga hutchinsonii and several other species that has a different, shorter architecture and is represented by a separate model. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Bacteroidetes with members of this protein family appear to have all of the genes associated with gliding motility.	0
NZ_CP043612.1\|WP_111377306.1\|739749_740949_+\|alkaline-phosphatase-family-protein	gnl\|CDD\|293742	cd16018, Enpp, Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin. Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles.	1.66163e-94
NZ_CP043612.1\|WP_111377305.1\|741312_742842_-\|SulP-family-inorganic-anion-transporter	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	4.67932e-120
NZ_CP043612.1\|WP_111377313.1\|726657_727809_-\|formimidoylglutamase	gnl\|CDD\|212514	cd09988, Formimidoylglutamase, Formimidoylglutamase or HutE. Formimidoylglutamase (N-formimidoyl-L-glutamate formimidoylhydrolase; formiminoglutamase; N-formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; HutE; EC 3.5.3.8) is a metalloenzyme that catalyzes hydrolysis of N-formimidoyl-L-glutamate to L-glutamate and formamide. This enzyme is involved in histidine degradation, requiring Mn as a cofactor while glutathione may be required for maximal activity. In Pseudomonas PAO1, mutation studies show that histidine degradation proceeds via a 'four-step' pathway if the 'five-step' route is absent and vice versa; in the four-step pathway, formiminoglutaminase (HutE, EC 3.5.3.8) directly converts formiminoglutamate (FIGLU) to L-glutamate and formamide in a single step. Formiminoglutamase has traditionally also been referred to as HutG; however, formiminoglutamase is structurally and mechanistically unrelated to N-formyl-glutamate deformylase (also called HutG). Phylogenetic analysis has suggested that HutE was acquired by horizontal gene transfer from a Ralstonia-like ancestor.	1.53502e-94
NZ_CP043612.1\|WP_111377309.1\|732752_734012_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	8.19331e-108
NZ_CP043612.1\|WP_111377308.1\|734112_734616_+\|lipoprotein	gnl\|CDD\|377341	pfam04390, LptE, Lipopolysaccharide-assembly. LptE (formerly known as RplB) is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported from its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptD appears to be anchored in the outer membrane, and LptE forms a complex with it. This part of the machinery complex is involved in the assembly of lipopolysaccharide in the outer leaflet of the outer membrane.	3.83028e-07
NZ_CP043612.1\|WP_111377303.1\|743552_743759_+\|hypothetical-protein	gnl\|CDD\|235089	PRK02946, aceK, bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated.	0.00033719
NZ_CP043612.1\|WP_111377310.1\|732250_732622_+\|GxxExxY-protein	gnl\|CDD\|275083	TIGR04256, conserved_hypothetical_protein, GxxExxY protein. Members of this protein family average about 130 residues in length and include an almost perfectly conserved motif GxxExxY. Members occur in a wide range of prokaryotes, including Proteobacteria, Perrucomicrobia, Cyanobacteria, Bacteriodetes, Archaea, etc.	2.70628e-51
NZ_CP043612.1\|WP_111377307.1\|737794_739426_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
NZ_CP043612.1\|WP_008467105.1\|736920_737196_+\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	2.08336e-48
NZ_CP043612.1\|WP_111377311.1\|730717_732163_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237676	PRK14329, PRK14329, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0

>NZ_CP043612.1|WP_111377419.1|737282_737639_+|four-helix-bundle-protein
MRDFKKYDIWQLSHSLTLEIYKLTSLFPKEELYGLTSQIRRASSSIPTNISEGCGRNSDKEFNQFLNIALGSANETEYLLILARDLQYLNSEIAENQIEKINSIKSKIYKLKQVLVQQ
>NZ_CP043612.1|WP_008467105.1|736920_737196_+|co-chaperone-GroES
MALNIKPLSDRVLIEPVAAETKTASGIFIPDTAKEKPQKGTVVAVGNGTKDHTMTVKVGDTVLYGKYAGTELKLEGTDYLIMREDDILAII
>NZ_CP043612.1|WP_111365084.1|736431_736776_+|preprotein-translocase-subunit-SecG
MSTFSIFLVLITIVCFLLIVVIMVQNPKGGGLSSTISGTQMLGGVQKTTDFLDKSTWTLATVLIVLILLSSLSFSGSLSDTESKIIDKTEAPANAPAAPAQGTTPAPATPAPAK
>NZ_CP043612.1|WP_111377308.1|734112_734616_+|lipoprotein
MKKIYSLFALLSLFMLSGCSVYNFTGTGKIDAKTFQVNFFQNNADLIEPGIDRIFTLALQDLIMNQTNLNLVSNGGDLVYEGEITDYRITPMTATADQQAAQNRLSIRVNVRFMNKKKETDDFEKSFEFYYDFPGRDLPTGSVLSEAIRVIFERITQDIFNESLAKW
>NZ_CP043612.1|WP_111377309.1|732752_734012_+|sigma-54-dependent-Fis-family-transcriptional-regulator
METVQAIKQRFEIIGNDPKLNRAIEKAIQVAPTDISVMVTGESGVGKENIPRIIHSLSHRKHGKYIAVNCGAIPEGTIDSELFGHEKGAFTGATSTREGYFEVADGGTIFLDEVGELPLTTQVRLLRVLENGEFIKVGSSQVQKTNVRIVAATNVNLFNAIEKGKFREDLYYRLSTVEITLPPLRERNDDIHLLFRKFVADFAHKYKMPPLRLDDDAVQLLQKFRWSGNIRQLRNVAEQISVLETNRDISLATLQSYLPAEGSNLPSVINDSKKESDFSTERDILYKVLFDMRSDLNDLKKLTLELMKNGTSKVQDINPNLIQKIYGNQQNDSEIDFEEEPRTAVMTTPTVREDNYQMQDDNYLFAETIEEEEILRLEQKEIEMIKKSLEKNKGKRKAAADELGISERTLYRKIKQFDL
>NZ_CP043612.1|WP_111377310.1|732250_732622_+|GxxExxY-protein
MQHYKEKETYKIIGICMEVHRNLGPGLLEVVYKDALEVEFKENNIPFEREKEYSIEYKGKVLAHKFYADFIINEDIVLEVKAIREFSSEHIAQILNYIKISDSEVGLLVNFQTKSLQYKRYIL
>NZ_CP043612.1|WP_111377311.1|730717_732163_+|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MEKIIEESKQGESLVLENKPENTKKLFIESYGCAMNFSDSEVVASILSDGGYNTTSVLEEADLVLVNTCSIRDKAEQTIRKRLEKYNAVKRTNPKMKVGVLGCMAERLKSQFLEEEKIVDLVVGPDAYKDLPNLLAEVEEGRDAINVILSKEETYGDISPVRLMSNGITALVSITRGCDNMCTFCVVPFTRGRERSREPQSIMNEIQDLWNNGYKEVTLLGQNVDSYLWYGGGLKKDFVNASEMQKATAVDFDQLLEMVAVGFPKMRIRFSTSNPQDMHESILHVIAKYPNICKHIHLPVQSGSNRILKEMNRLHSREEYMALIDKIRAIVPDASISQDMIAGFPTETEEDHQDTMSLMEYVKYNFGYMYSYSERPGTLAGRKMKDDVEEETKARRLQEIVDLQQKHAWFRSEEFVGKTVEVLVEKVSKKSKDEFSGRNSQSITVVFPKENYKIGDFVNVKITSCTSGTLKGEGVGLSSMN
>NZ_CP043612.1|WP_111377312.1|727817_730346_-|type-I-DNA-topoisomerase
MAKNLVIVESPAKAKTIEKFLGSDFQVESSYGHIADLPSKEIGVDVENGFKPKYEVSPDKKALVTKLKSLSKNAETVWLASDEDREGEAISWHLAEELKLDRKKTKRIVFHEITKSAILKAIDNPREIDYNLVNAQQARRVLDRLVGYELSPVLWRKIKGGLSAGRVQSVSVRLIVEREREIQSFNAVATYSIVAEFVNEAGKAFKAKLPKNFNTKKEAEDFLNQNIGSKYKVADLETKPTKKSPTAPFTTSTLQQEAARKLYLPVGITMQLAQRLYEAGLITYMRTDSVNLSKEAMDAAQAEIIKSYGKEFSKPRVFANKNKGAQEAHEAIRPTDMSRHTVNIDRDQARLYDLIWKRTLASQMSDAQLERTNVKIEADNHDEIFTASGEVLLFEGFLKVYLEGHDDDEEEQEGMLPALKVNEKLANNYITATERYSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIINRNYVEKGTLEGVERNYTQLTLQNSKVGEKVLKENTGSDKGKLVPTDIGTIVTDFLVKNFGNILDYNFTAKVEQDFDEIAEGNIDWAKMMQDFYNKFHPNVKEVEANAERESGERILGKDADGRQVSVRLGKFGPMAQIGEADDEDKKFASLMADQNIGNITLEEALNLFLLPKSLGEYKGEEVEVNNGRYGPYVRHGSVFISLPRGEDPLNVSKERAQELIDEKALADAPIAVYKGEAVQKGVGRFGPFIKWNGLFVNVSKKYNFDNLSQADVEELIEEKLQKNIDKVIHNWEEEGIVVEKARWGRSVILKGKVKIELSKDVDATKLTLAQVQEMIAAKTPAKKAPAKKTAAKTTTAKKAPAKKTAAKKK
>NZ_CP043612.1|WP_111377313.1|726657_727809_-|formimidoylglutamase
MEFDFLEPVNDGIIRFVGGLSSQELGSKVVFHTQDQFPDIAQINIAIVGVLEDRTNINMINEVNLSAVRKKLYSMFPGNWDASIADLGDILAGDSVEDTYFALKKVTAALIKNKVIPIVLGGSQDLTYALYRAYDDLEQMVNLVAVDNKFDFGKENESVSANSYLTKIIIDEPNNLFNYCNIGYQTYYNSQEEIDLIEKLFFDAYRLGEISNKITLAEPVFRDADLVSIDLNSVKSSASANMVTFEPNGFNGKEICALARYAGISDKVSSFGVFNHNSTLAESAIIAQIVWYFIEGYHYRSKEYPFGSRANYLKYIVPLDDEELIFYKSDKTDRWWIEIPYESNGSNKLKRNTLLPCSYEEYLSACNQELPERWWKAQRKNAL
>NZ_CP043612.1|WP_111377314.1|725000_726395_-|gliding-motility-lipoprotein-GldK
MKKFIAFAAMLTLVIGCGKSGDKGELVGVTGGKWHPEKPYGMTLVPGGSFIMGKSDADLANVEDAPTKTVTVRSFYMDETEITNSEYRQFVEWVKDSTMRVRLAILADETGQKATDGKGKKGGSIADYAFNDSDPEKMTAYDKYMYDNYYSVGTKDDPYAGRKLNRKVKLIKDTKAYPDEYYTEVMDSMYLPIEESYNGLRTIDVNKLKFRYSWMDIQAAAKAKVGKRSDFVKTEQVNVYPDTAVWIKDFAYSYNEPMHNDYFWHKAYGDYPVVGVTWKQAKAFCAWRTLNKNSYIKSKKKGRDLVNAFRLPTEAEWEYAARGGLESATYPWGGPYTKSDRGCFLANFKPSRGDYAADEALYTVEAKSYDVNGYGLYNMAGNVSEWTDSAYNPNAYEYVSTMNPNVIDGKNQRKVVRGGSWKDVAYFLQVSTRDHEYADSARSYIGFRTVQDYMGTQVTGNRKK
>NZ_CP043612.1|WP_111377307.1|737794_739426_+|chaperonin-GroEL
MAKDIKFDIEARDGLKRGVDALANAVKVTLGPKGRNVIIGKSFGGPTVTKDGVSVAKEIELKDALENMGAQMVKEVASKTNDLAGDGTTTATVLAQAIVKEGLKNVAAGANPMDLKRGIDKAVETIVADLAKQAKVVGSDSDKIQQIASISANNDEVIGELIATAFAKVGKEGVITVEEAKGTDTFVDVVEGMQFDRGYLSPYFVTNPEKMEVELDSPYILLYDKKVSSLKELLPVLEPVAQSGKPLLIIAEDVDGEALSTLVVNKLRGALKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEERGYTLENTTIEMLGNAKRVSIDKDNTTIVSGAGEADIIKNRVNQIKGQMETTTSDYDKEKLQERLAKLAGGVAVLYVGAASEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALLRAKLALADLKADNADEATGIQIVSRAVEAPLRTIVENAGLEGSVVVAKVAEGAGDFGYNAKTDEYVDMLKAGIIDPKKVTRVALENAASVSGMILTTECALIDIKEENAGGGMPMGGGMPGMM
>NZ_CP043612.1|WP_111377306.1|739749_740949_+|alkaline-phosphatase-family-protein
MKKHFTYLLSFTFLLLSLTIQAQTNKDNYVVLVSMDGFRWDYGKMYNLPNLKQIEKEGVHAKSMKPSYPSKTFPNHYSIVTGLYPDHHGIINNVFYDASLNQAFSLSSNAKNDSRFYGGNPIWNLAEEQGVKTASFFWPGSDIDNRNPSYFKNYDGKVPYGARIDTVMKWLQLPEKQRPHLVTLYFDEPDHTGHNFGPLSPKTEKTVIKMDSIMGEISRRLDQLPIGKQINLIIVSDHGMATISNDKKVAVLDYIKPEWLGYKDVINPIMSLQAKPGYQDSIANALKKVPHIKFWKSTEVPERLHYGTNPRVHDFVIEADKGWSLVSKESTHINGGTHGYDNDEKDMHAIFYAKGPAFKVNKKVKPFQNVSVYPLIAHILGLQVGEIDGKLSDVEAMLR
>NZ_CP043612.1|WP_111377305.1|741312_742842_-|SulP-family-inorganic-anion-transporter
MKKAFQLFDFSQKVNYKNEILAGLTVAMTMIPESLSFAILAGFPPLVGLYAAFIAGLVTAIFGGRPGMISGGAGATVIVLIALMKSHGIEYVFAAVALGGVVQICIGLFKLGKFIRLVPQPVMFGFVNGLAVVIFMSQLEQFKTVVNGQVSWLQGTPLYIMLGLVALTIAIVLIFPKITKAVPASLVAIMVVFALVIVFNIETKTVEDIASVQGGFPPFHIPNIPFSFETLKVIFPYSVIVAAVGLTEGLLTLNLVDEITGTRGNSNRECIAQGSSNILNGFFYGMGGCPMIAQTLVNLGAGSRARLSGIIAALTILLIILFGAPVIGKLPMAALVGVMMMVAITTFEWASFRIINKMPKHDILVGILVAVITIVLHNLALAVLIGVIISALVFAWESAKRIRARHYIDENGIKHYEIYGPLFFGSTTTFLEKFDIQNDPNHIIIDFKESRVSDMSAIEALNNITKKYNQLNKTVELQHLSADCRQLLKNADAVINVNVIEDPTYKVVS
>NZ_CP043612.1|WP_111377304.1|743066_743462_-|peptidase-S24
MIENTIHRIKQYIDFKGIKVSIFEKEVGMSNGSFASQLKNNKTIGVDKLENILKKYSEINIEWLLTGNGNMLKCDVLNEEGLVYNRTEKEDTEKLINYKELAEARKETIESLQKVILYLETQIAANSQNKK
>NZ_CP043612.1|WP_111377303.1|743552_743759_+|hypothetical-protein
MGKNIKSKPSYNQDVLKIIKDRYGYSYDYIRKSIRGDRVGIICDMLKTEYHKLNNESIKAIESRAYKL
>NZ_CP043612.1|WP_111377302.1|743799_744954_+|hypothetical-protein
MKKITYLLLLIQSGFLTAQTKTVVTQFGEKVSINPYVNNGLETNNGYIQLGGALTKPSILTTTPNFTLAFTGLQAGGASDNVLVTDASGVLKSVARSSFGGNDNLGNHIATMDLNMSNKNITNIYNAYIKNDFQIFDRITSNTNYFGLYKTQGKLGIWNNAKSANALTIDENTNTTTLQSAAIAKGTDNKTPVPGSVATAADTNGNVIWTATSEVTGVLVGAYNVTGSGLPLQDIPISSTINDYYDINGLTLSITVTKPSRLVVVGSVLVTSSSAGYTGQGSIATFVDGVKYNPNYYSFFDGYANGASGGLVRLGSTVPVNTVVDVEPGTHTIKLRVRAWASYIGGISNSTIKHRINPTTGSYLGSFNETGAQAPNMTVLVYTK
>NZ_CP043612.1|WP_142479110.1|745298_746396_+|hypothetical-protein
MKNLTCMLLLICSGFVMAQTKTVVTQNGEKVTISPTVDNGLTATNGHIQLGGALTKPSVLATTSAFTLAFTGLQTGGASDNVLVTDASGVLKYVPRSSFSGADNLGNHIATQDLNLSNFNLLNIKNAYIKNDLQIFDRITSNTNYFGIYKNQGKFGIWNNVKSTNALTIDESNNKTTLLSAQITAGTNGSAPQTGYMLTAADPSGNLVFTAPKAIPGAISGVYEFLGTDLISIPANTTATIPMNANSFTMSTSGKALITYSVLPLPANASQPVQGSIDLIIDNTKMISSYYSATDSPSTLVKLGNYSTAQKMISLPAGTHTVGVNLKSWSGTTRTNVNPFPSYVGSIANDNQAMVARITVITFND
>NZ_CP043612.1|WP_142479111.1|747495_748260_+|hypothetical-protein
MTAQTKTVVTQHGEKVQFDPNSIGSADNGLTALNKNVQLGGELNKRTTIKASTTNTIAISGLTSSNNTSDTPVVATADGTLKKGAFPMINILPDDIGTVIAIDGKLEVAQEISAMITANLNIAGTTGNIPTPLGGMTKVFIDNRHTFYSDSNTNYFTIKTTGIYAVNINVPVTPSAASTPAVGVWCNTDNKWVARVNLDAVQKVPLTLMTSITLDASKTYSFRVINTVDLLVEALNYGTSGTGPVGFFSIKRLK
>NZ_CP043612.1|WP_111377299.1|748391_749201_+|hypothetical-protein
MKKITCLLLLFQCLCTIAQTKTVITPHGEKVQINPNLIGTADNGLTLTNKNIQLGGELNKPTTIKTSQANPLAIDGLAVSPNTNDIPLVVDANGVLKKGAFPVINIVPDNIGTVIAIDGKLEVAQEITAMMTANYSFAAGTPYAIGNLTNVLIDNQNTFKSSATTNSFTIKTAGVYAVTMNMPLITTDGGMVVIGVYCDTDSLWVARININVITVGRRTNLTLLTAINMDPAKTYSFRVGNTVPSTVEAINSDNTGSGPSASVSLKRLK
>NZ_CP043612.1|WP_149229128.1|749426_750080_+|hypothetical-protein
MQLGGDLTKPTTISTSATNTLAITDLTTSTNTNDTPIVVAADGTLKKGAFPSINIVPSEIGTVIAVNGKLEVAQEIIALMSGNFSINGTTGTTPAVIGNITNIIVDNLQTFSGTATSNSFSVATTGVYSIKMSLPVIQSTGTQAIGLWNNTDNKWMARISIVLTGRTNCNLVSSTNLEAGKTYSFRAANTTNFTIEGLNLNPAGTASVASFSVKRLK

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Crispr_ID: NZ_CP043612_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_2

1170762-1170837

Orphan

Consensus_repeat	Method
AAAGCCTAAAGCTTAAGGCCTAAAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_2

>merge|NZ_CP043612|2|1170762-1170837|CRISPRCasFinder
ATATAAAAAAGCTTAAAGCCTAAAGCTTAAGGCCTAAAGCAATACAAAAACAAGCTAAAAGCATTAGGTAAAAAGC

>NZ_CP043612|2|2|1170762-1170837|CRISPRCasFinder
ATATAAAAAAGCTTAAAGCCTAAAGC	TTAAGGCCTAAAGCAATACAAAAA
CAAGCTAAAAGCATTAGGTAAAAAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111379469.1\|1180637_1181213_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379455.1\|1168935_1169904_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
NZ_CP043612.1\|WP_008466556.1\|1170069_1170693_+\|bifunctional-nuclease-family-protein	unknown	unknown	gnl\|CDD\|376830
NZ_CP043612.1\|WP_111379457.1\|1170869_1171721_+\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|234984
NZ_CP043612.1\|WP_111379452.1\|1163233_1163833_-\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP043612.1\|WP_111379460.1\|1173712_1174444_+\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	unknown	unknown	gnl\|CDD\|234689
NZ_CP043612.1\|WP_008466558.1\|1168123_1168870_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|238847
NZ_CP043612.1\|WP_111379450.1\|1162591_1163122_-\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
NZ_CP043612.1\|WP_111379453.1\|1164073_1166575_-\|carboxypeptidase-like-regulatory-domain-containing-protein	unknown	unknown	gnl\|CDD\|372685
NZ_CP043612.1\|WP_008466560.1\|1166644_1167622_-\|pyruvate-dehydrogenase-complex-E1-component-subunit-beta	unknown	unknown	gnl\|CDD\|223101
NZ_CP043612.1\|WP_167511689.1\|1175970_1178505_+\|BamA/TamA-family-outer-membrane-protein	unknown	unknown	gnl\|CDD\|366466
NZ_CP043612.1\|WP_111367760.1\|1172294_1172639_+\|2TM-domain-containing-protein	unknown	unknown	gnl\|CDD\|379083
NZ_CP043612.1\|WP_111379466.1\|1178566_1179634_+\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NZ_CP043612.1\|WP_111379463.1\|1175165_1175894_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|349982
NZ_CP043612.1\|WP_111379447.1\|1159507_1159876_+\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|227786
NZ_CP043612.1\|WP_111379458.1\|1172650_1173133_+\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|365932
NZ_CP043612.1\|WP_111379637.1\|1171758_1172055_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|199892
NZ_CP043612.1\|WP_111379449.1\|1159934_1162478_-\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|376979
NZ_CP043612.1\|WP_111379461.1\|1174445_1175156_+\|PorT-family-protein	unknown	unknown	gnl\|CDD\|372635
NZ_CP043612.1\|WP_111379445.1\|1159204_1159501_+\|type-II-toxin-antitoxin-system-HigB-family-toxin	unknown	unknown	gnl\|CDD\|378301

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111379455.1\|1168935_1169904_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	3.34836e-86
NZ_CP043612.1\|WP_008466556.1\|1170069_1170693_+\|bifunctional-nuclease-family-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	3.13621e-60
NZ_CP043612.1\|WP_111379457.1\|1170869_1171721_+\|thymidylate-synthase	gnl\|CDD\|234984	PRK01827, thyA, thymidylate synthase; Reviewed.	0
NZ_CP043612.1\|WP_111379452.1\|1163233_1163833_-\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	2.31925e-50
NZ_CP043612.1\|WP_111379460.1\|1173712_1174444_+\|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	gnl\|CDD\|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	3.49598e-101
NZ_CP043612.1\|WP_008466558.1\|1168123_1168870_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	4.86825e-60
NZ_CP043612.1\|WP_111379450.1\|1162591_1163122_-\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	4.07363e-86
NZ_CP043612.1\|WP_111379453.1\|1164073_1166575_-\|carboxypeptidase-like-regulatory-domain-containing-protein	gnl\|CDD\|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	5.41419e-13
NZ_CP043612.1\|WP_008466560.1\|1166644_1167622_-\|pyruvate-dehydrogenase-complex-E1-component-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
NZ_CP043612.1\|WP_167511689.1\|1175970_1178505_+\|BamA/TamA-family-outer-membrane-protein	gnl\|CDD\|366466	pfam01103, Bac_surface_Ag, Surface antigen. This entry includes the following surface antigens; D15 antigen from H.influenzae, OMA87 from P.multocida, OMP85 from N.meningitidis and N.gonorrhoeae. The family also includes a number of eukaryotic proteins that are members of the UPF0140 family. There also appears to be a relationship to pfam03865 (personal obs: C Yeats). In eukaryotes, it appears that these proteins are not surface antigens; S. cerevisiae YNL026W (SAM50) is an essential component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The protein was localized to the mitochondria.	7.3784e-19
NZ_CP043612.1\|WP_111367760.1\|1172294_1172639_+\|2TM-domain-containing-protein	gnl\|CDD\|379083	pfam13239, 2TM, 2TM domain. This short region contains two transmembrane alpha helices that are found associated with a wide range of other domains. This domain may be involved in cell lysis or peptidoglycan turnover.	5.31715e-18
NZ_CP043612.1\|WP_111379466.1\|1178566_1179634_+\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NZ_CP043612.1\|WP_111379463.1\|1175165_1175894_-\|RNA-methyltransferase	gnl\|CDD\|349982	cd18109, SpoU-like_RNA-MTase, SAM-dependent RNA methylase related to SpoU-TrmH. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	3.26674e-81
NZ_CP043612.1\|WP_111379447.1\|1159507_1159876_+\|DNA-binding-protein	gnl\|CDD\|227786	COG5499, COG5499, Predicted transcription regulator containing HTH domain [Transcription].	2.36632e-33
NZ_CP043612.1\|WP_111379458.1\|1172650_1173133_+\|dihydrofolate-reductase	gnl\|CDD\|365932	pfam00186, DHFR_1, Dihydrofolate reductase.	4.55685e-88
NZ_CP043612.1\|WP_111379637.1\|1171758_1172055_-\|glycoside-hydrolase	gnl\|CDD\|199892	cd07184, E_set_Isoamylase_like_N, N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins. E or "early" set domains are associated with the catalytic domain of isoamylase-like proteins at the N-terminal end. Isoamylase is one of the starch-debranching enzymes that catalyze the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase contains a bound calcium ion, but this is not in the same position as the conserved calcium ion that has been reported in other alpha-amylase family enzymes. The N-terminal domain of isoamylase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and the beta subunit of AMP-activated protein kinase.	1.37199e-32
NZ_CP043612.1\|WP_111379449.1\|1159934_1162478_-\|sodium-translocating-pyrophosphatase	gnl\|CDD\|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0
NZ_CP043612.1\|WP_111379461.1\|1174445_1175156_+\|PorT-family-protein	gnl\|CDD\|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	1.27492e-14
NZ_CP043612.1\|WP_111379445.1\|1159204_1159501_+\|type-II-toxin-antitoxin-system-HigB-family-toxin	gnl\|CDD\|378301	pfam09907, HigB_toxin, HigB_toxin, RelE-like toxic component of a toxin-antitoxin system. HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.	1.55013e-31

>NZ_CP043612.1|WP_008466556.1|1170069_1170693_+|bifunctional-nuclease-family-protein
MSLVKLSIKGISYSQTQNGAYALILNEVDGERKLPIVIGAFEAQSIAIALEKEIKPPRPLTHDLFKNFAERFDIVVKQVIIHKLVDGVFYSSLICERDKIEEIIDARTSDAIALALRFNAPIFTYKNILDKAGIYLKSNTAETDSGAQEIDDVLSNPETFGHEEESNQSGDVYAKHSLQELNELLDQAVSQEDYEKAAKIRDEISRR
>NZ_CP043612.1|WP_111379455.1|1168935_1169904_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MSILIYAESAEGKFKKVAFELASYAKKVAESLGTTVTALTVNISDVSELGKYGVDKVLKVSNDKLAGFNAKAYADVIKQAAEKEGTKVVLLSSTTDSIYLSPLVAVALNAGFASNVVGLPVSTSPFQVKRNAFSNKAFNITQIDTDVKVLGLAKNSYGLFESTGAAAAEDFNPTVGDNDFGVKVESVEKVSGKVSIADADIVVSGGRGLKGPENWGLVENLAAVLGAATACSKPVSDLGWRPHSEHVGQTGKPVATNLYIAIGISGAIQHIAGINSSKVKVVINNDPEAPFFKVADYGVVGDAFEIVPQLTEKLKAFKAQHS
>NZ_CP043612.1|WP_008466558.1|1168123_1168870_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MKILVCISHVPDTTSKINFTNGDSEFDTNGVQYVINPNDEFGLTRAIWFQEQQGANVTVVNVGGPDTEPTLRKALAIGANEAIRVNANPTDGFFVAKQLAEVIKNGGYDLVIAGKESLDYNGGMVPGMIAGILGYNFLNSCTALTVDGNNVKAVREIDGGKETVSTTLPLIIGGQKGLVEEKDLRIPNMRGIMTARTKALTILEPVDAAVNTKAVKFEKPAPKSAVKLVSADNLDELINLLHNEAKVI
>NZ_CP043612.1|WP_008466560.1|1166644_1167622_-|pyruvate-dehydrogenase-complex-E1-component-subunit-beta
MRTIQFREAICEAMSEEMRRDESIYLMGEEVAEYNGAYKASKGMLAEFGEKRVIDTPIAELGFSGIAVGSAMNGNRPIVEYMTFNFCLVGIDQIINNAAKMRQMTGGQFNVPIVFRGPTASAGQLGATHSQALENWFANTPGLKVVVPSTPYDAKGLLKSAIRDNDPVIFMESEQMYGDKGEVPDGEYTIPLGVADVKREGTDVTIVSFGKIIKEAFIAADELAKEGISCEIIDLRTVRPMDKDAILKSVKKTNRLVILEEAWPVASLSSEISYIVQEQAFDFLDAPIQRITTADTPAPYSPVLLKDWLPNAGDVVKAVKKVLYK
>NZ_CP043612.1|WP_111379453.1|1164073_1166575_-|carboxypeptidase-like-regulatory-domain-containing-protein
MNKLTLLLLYFLFAFANVATAQTKVSGVVLDKSNQPIPFANVVFKGSNIGIVSNEDGRFYLESPNTYTALMVTSAGFSDKEVPLEKAVNYNFKIVLFEEQVLNEVVIYTGKTSKKNNPALDILRKIWERKRKNGLYLFNQYQMQKYEKVEFDMNTIDSAFMKNKLFKGMEFIFNHVDTSDVTGKTYLPIFINESVYDVYGDNKLKKVKENLTGNKMSGFNGNQQILSFVKDLYSDYNIYDNHLKFFDKSFTSPLSRTGIDVYNYVLKDSAFVDKKWCYNIVFYPRRKNELTFKGDFWVNDTTFAIKKINMGVTKSANINWVKDIYIEQEFEVENDSVFLLTRDYMMSDFALNKKEKSKGVYGKRTTLYRNHKFNIQKPEKFYKEEVNFIDNAVYERPPEFWEENRFEKLNKDEQGIYKMLDTLQTVKRFKQLYNLVSILGSGYIEFKNFDYGPIFSTFGYNEVEGIRLRVGGRTYFGPNDPWRIQAYTAYGFDDNKFKYGVSGKWMVDKKNRVIISGGNRRDIEQIGASLTTTNDVLGRSFASSALFTTGSNGKLTNINLSNVSVEMEPKKNFIVSAGLSYRTLESASKTFSLDYYTTLPTAANPAGVVESMVKQSEANIQFEFMPNRKTIGYGVERSLVDSPFSHFFVNFSYGLKGVFDSDFAYEKIQVFYRQPIIIGPLGRTNITIETGKTFGTIPLGLMSVIPGNQTYFTIENTFSNLNFYEFVTDQYTTLQWNHDFGGRLFARIPFMRKLNWREFVGIRAVHGTISDANRAINASGLPYNAPEKVYWEYNAGIGNIFKVFRLDFSWRGNYLDMPDAHKFAIKGSFGFYF
>NZ_CP043612.1|WP_111379452.1|1163233_1163833_-|DNA-3-methyladenine-glycosylase-2-family-protein
MQEAIDFLTNKNPIFLEIIEKYGLPPIPRRPPGFETLVLLILEQQVSIDSAKATFLKIKAFTTCNPENMAVLSDEEFRSLGVSRQKTKYIKILAEAVLNKELDIESLASKSAKQVREELIKLKGIGNWTIDIYLMFCLEEPDLIPLGDIAVINTIKELLNIHDKQEMEIHAKQWSPYRSYATYLLWHYYLKKRNRTITY
>NZ_CP043612.1|WP_111379450.1|1162591_1163122_-|inorganic-diphosphatase
MTADKLTTFDVLIEIPRGSRNKYEYDFEIKRMRFDRMLFSSMMYPADYGFIPETLALDGDPLDVLVLVNEPTFPGCVMEVKPIGVFHMADDKGPDEKIICVPVSDPIWNSLNDLSDINAHLLKEIEHFFQVYKDLENKKVDVEGWGDVKEAYDIIAECTKRFDDIENKPAGLFSIK
>NZ_CP043612.1|WP_111379449.1|1159934_1162478_-|sodium-translocating-pyrophosphatase
MNAFMIYLPIIMAVLGLLFMGIKRTWVLKQDAGDGKMKEISDYIYEGALAFLKAEYKLLTIFVIIASLALAGITFIPGVKTHLLIVIAFIFGAFFSALAGNMGMKIATKTNVRTTQAARTSLPQALKVSFGGGTVMGLGVAGLAVLGLTSFFIIFFHLFSGGVWKDTDTMTVVLETLAGFSLGAESIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDVAGMGADLFGSYVATVLAAMVLGNYVIKDMGGSINDAFGGIGPILLPMAIAGFGILFSIIGTTLVKISDDNAKEAQVQKALNIGNWVSIVLTAVACFFLVQHMLPETMQMTFFGEGSKAISSMRVFYATLVGLVVGGAISSVTEYYTGLGTKPVLAIVQKSSTGAGTNVIAGLATGMISTFPTVLLFAVAIWISYALAGFYGVALAASAMMATTAMQLAIDAFGPISDNAGGIAEMSELPKEVRTRTDILDSVGNTTAATGKGFAIASAALTSLALFAAYVTFTGIDGINIFKAPVLAMLFVGGMIPVVFSALAMNSVGKAAMDMVYEVRRQFKEIAGIMEGTGKPEYGKCVEISTKAALREMMLPGVLTIGFPILIVIIGKLVYADNNQLIAEMLGGYMAGVTVSGVLWAVFQNNAGGAWDNAKKSFEAGVMINGEMTYKGSDAHKAAVTGDTVGDPFKDTSGPSMNILIKLTCLIGLVVAPILGEGHSESNIAGKASCCAKTEMHAGMSKCGDMSGMTKEECIKMCKEKGCSEEETAKCLAHFDKTGKYQKTDCFDTSKYEKQSVRVEVKNINGKTTGTVTKTVDGKTTTEVFEGTEEEVLAKVEAVK
>NZ_CP043612.1|WP_111379447.1|1159507_1159876_+|DNA-binding-protein
MNIKPIKTEHDYSLALERVNFLFDAKPDTAEGDELDILVTLIEKYEQIHYPIPEPDPIEAIKFMMEQNGLSDADLGIILNSRSRVSELFNRKRALTIKQIRVLTETLHIPASTLIKEYALNQ
>NZ_CP043612.1|WP_111379445.1|1159204_1159501_+|type-II-toxin-antitoxin-system-HigB-family-toxin
MRIIAKRTLQNFWERFPNSKQQLLSWYQVFDKNNFSNSNAVKSFFGTADFVGNNKVIFNICGNHYRLIVKINYETQIVYILFIGTHNEYDDLNDIKNL
>NZ_CP043612.1|WP_111379457.1|1170869_1171721_+|thymidylate-synthase
MKQYLDLVKHVLENGNQKGDRTGTGTKSVFGYQMRFDLSEGFPMVTTKKLHLKSIIYELLWFLKGDTNIKYLQENGVKIWDEWADSNGDLGPVYGHQWRNWNSEEIDQISELITELKTNPNSRRMLVSAWNPSVLPDTKKSFEENVANNKAALPPCHAFFQFYVASPDPEKGETKGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVCDLEPGEFIHTFGDAHIYNNHFEQLELQLTREPKPLPKMILNPEIKNIFDFDFNDFTLVDYDPHPAIKGSVAV
>NZ_CP043612.1|WP_111379637.1|1171758_1172055_-|glycoside-hydrolase
MSLKKQFIKTKPVVKVTFSIDAKDADSAAVVGDFNNWNASEGALSKLKNGTFKATYDLVKDAIYEFKYLVDGNYVNDPEADSYKWNDFAGSENSVLIV
>NZ_CP043612.1|WP_111367760.1|1172294_1172639_+|2TM-domain-containing-protein
MEKEVHEQYEYARRRLRQKKVLYFHFVLFLLGSLFLFIANRFFGFGQGTSQNWCIWGITIWLFLFILHFIKVYITDRFMNKKWEREQIDRLVALQQKRISQLESSINEENENKI
>NZ_CP043612.1|WP_111379458.1|1172650_1173133_+|dihydrofolate-reductase
MIIMIAAAAENNALGKNNELVWHLPNDFKRFKSLTTGHHIIMGRKTFESFPKPLPDRVHIVISRQENYKPEGCIVVDSIEKAIAICPENDDSYVIGGGEIYNLALPFTDIIELTKVHHSFDADAFFPKINKSEWVLVESEENYKDEKHLYDYTYETYIRK
>NZ_CP043612.1|WP_111379460.1|1173712_1174444_+|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE
MSEKITPYKDSSLGKKEQVTQMFDTISGNYDNLNRVISFGIDVKWRKKVLKIVSDKKPKVILDIATGTGDLAILLSQTNAEKIIGLDISAGMLEVGKKKVEEKKLSNVIELVLGDSENMPFEDNYFDAITVGFGVRNFENLEKGFSEILRVLKPNGVFVILETSVPDKFPYKQGYNFYSKNILPLIGKLFSKDNDAYGYLSESAAAFPYGEALNNILRKTGFIDVVAMPQTFGVATIYSASKK
>NZ_CP043612.1|WP_111379461.1|1174445_1175156_+|PorT-family-protein
MKKVVILFLLVLTTKGHSQFAKNMFSKDPIINLENWQKQRIYFGYYLGFNSFDFKFDYKTPVQEDIQVKKTTGFNVGVVADLRLQEYINLRFEPGLYYTKRDLYFPGISNKESDYLREVNSTYIHFPLLLKFSALRTGNIRPYLVGGMSTTLNLSSNAKSKDDNFEQKFRVKQWTAAYELGLGIDIFTEYFIFSPSVRGMFGITDELIRDNTPDSPWTGNIDSMKSRALLINFTFH
>NZ_CP043612.1|WP_111379463.1|1175165_1175894_-|RNA-methyltransferase
MVSKNQIKLISGLHQKKQRFANQLFFAEGVKVIQELLQSNFELEHLYTTLNDFQTVHASKRTVINEQELKKISALSTPNSCLAVFKIPAEKEIIHSGLILALDDIRDPGNLGTILRLCDWFGIEQIICSKETVDIYNPKVVQATMGSITRVNVSYVDLKLFLAQTKLPVFGTFMDGENIYQSKLPQDGIIIMGNEANGISEEIEKTVTSRLTIPRFGELQKTESLNVATATAIILSEFKRNS
>NZ_CP043612.1|WP_167511689.1|1175970_1178505_+|BamA/TamA-family-outer-membrane-protein
MAILICACNAVKRVPDGKNLLVKNNILVNGKSTNDETASNQMYQKPNGKLLGYKLRLNLYNLANLNPDSTYQAKFKNNPGKYERMSKIFSAKQVDRLGQSFYYKGIHEFLKNTGEPPVIIDTSKTKKSLLRLKYYYFNSGYFNVTTDYTIDTVGKKRAEINYNITTGPAYKLDTIRTKIMTPALDSLYRTNNEPSLLKSGNQYKTTDFDEEKNRITTYFRNHGAYYFQPTYVTFDIDTIGKKAKADVTLIINNNTIQGRDSSRTEPFKLYKISDVNIYTDYSAANAKKKPTDSVTYNNFNLYSYKTLKYKPRAITDAIFITKGSTFADFRTTLSSRYLNNLRIFNYPSIQYEVDKRDSTAQSLIANVYLTPRKKYSFGATLDVTHSNIQDFGIGASVSETIRNVFNRAETLEISARLNVGSSRDMANPNDNFFNVSEYGLDMKLNFPRILLPFGTEKIIPKSMIPYTSITSGFSKQRNIGLDKENFTGGISYNWTPKRHNTAKFELLNAQFVRNLNPDNYFNVYTSSYDDLNYIGKDYNVDPLNWGDTTEEQARKDLTIPKGTTGFTNDVLTGKTALTPGSSQYQEVESIEERRVRLTENDFILATSFSFTKTTKKDLADNNFYQFRTKIESAGTLLSLISEVGNLPKNTKGNYEIFNLEYSEYIKTEFDYIKHWDFGKEKVLAVRSFFGIAIPFGNSNYIPFSRSYYGGGSNDNRAWQPYALGPGSTNAVNDFNEANMKIAASAEFRFKIFGDVKGAFFADAGNIWNVLDNVIDPKARFDNLNDLAEIALGTGFGLRYDLSFFVIRLDLGFKTYNPAHEKGDRWFKEYNFGHSVLNFGINYPF
>NZ_CP043612.1|WP_111379466.1|1178566_1179634_+|class-II-fructose-bisphosphate-aldolase
MAHNIKPGVATGDQVQEIFNYAKEKGFALPAVNVTGSSTINGVLETAAKLNAPVIIQFSNGGAQFNAGKGLSNAGEKAAIAGGIAGAKHIHTLAEAYGATVILHTDHCAKKLLPWIDGLLDASEKHFAETGKPLFSSHMIDLSEEPIEENIEICKEYLARMSKMGMTLEIELGITGGEEDGVDNSDVDSSKLYTQPEEVAYAYEELSKVSPKFTIAAAFGNVHGVYKPGNVKLTPKILKNSQDFVQRKFNTGHNPVDFVFHGGSGSTLEEIREAIGYGVIKMNIDTDLQFAYTEGIRDYMVNNIEYLKTQIGNPEGADVPNKKYYDPRKWVRESEVTFNARLEQAFADLNNVNTL
>NZ_CP043612.1|WP_111379469.1|1180637_1181213_+|hypothetical-protein
MARIFIGFMICFLFLNCDKKENAPYLISIEKIKLLNELKKKNIPPPPPGFYSYNNIIIDQKGNFYFYQRESTPWHCIPSEKDTIPDFFDIKPIEITKIPNNTITDFIKQNVTSKNEMKRILIIASQNDTIKDKTLISYLNENELRAFCIRRTTQEEDTVLKYKKNNEYYSYKNIKWDQNRIILPFYKTEAK

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Crispr_ID: NZ_CP043612_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_3

1246489-1246603

Orphan

Consensus_repeat	Method
AAACTTTGCGAACCTTTGCGCTTTTTCTTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_3

>merge|NZ_CP043612|3|1246489-1246603|CRISPRCasFinder
AAACTTTGCGAACCTTTGCGCTTTTTCTTTGTGCCCTTTGCAGTTAAATCCTTTTCAAATTTTCTTTTGTGAGCCAATTCAAAAAAACCTTGCGAACCTTTGCGCTTTTTCTTTG

>NZ_CP043612|3|3|1246489-1246603|CRISPRCasFinder
AAACTTTGCGAACCTTTGCGCTTTTTCTTTG	TGCCCTTTGCAGTTAAATCCTTTTCAAATTTTCTTTTGTGAGCCAATTCAAAA
AAACCTTGCGAACCTTTGCGCTTTTTCTTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111379550.1\|1252386_1253994_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|380159
NZ_CP043612.1\|WP_111379539.1\|1243442_1243637_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379646.1\|1245472_1246207_-\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237348
NZ_CP043612.1\|WP_111379544.1\|1246742_1248236_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP043612.1\|WP_111379546.1\|1248246_1248480_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379547.1\|1248590_1251467_-\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|200488
NZ_CP043612.1\|WP_111379534.1\|1239271_1239712_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379541.1\|1243641_1244199_-\|LPS-export-ABC-transporter-periplasmic-protein-LptC	unknown	unknown	gnl\|CDD\|275202
NZ_CP043612.1\|WP_111379531.1\|1234584_1236756_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|366374
NZ_CP043612.1\|WP_111379645.1\|1238344_1239253_+\|GHMP-kinase	unknown	unknown	gnl\|CDD\|224493
NZ_CP043612.1\|WP_111379553.1\|1257248_1258280_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
NZ_CP043612.1\|WP_111379536.1\|1239977_1242077_-\|peptidylprolyl-isomerase	unknown	unknown	gnl\|CDD\|372650
NZ_CP043612.1\|WP_111379558.1\|1260622_1262926_+\|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl\|CDD\|237517
NZ_CP043612.1\|WP_111379549.1\|1251546_1252362_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379544
NZ_CP043612.1\|WP_111379533.1\|1236936_1238250_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	unknown	unknown	gnl\|CDD\|153082
NZ_CP043612.1\|WP_111379552.1\|1254030_1257012_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NZ_CP043612.1\|WP_111379538.1\|1242183_1243440_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NZ_CP043612.1\|WP_111379543.1\|1244250_1245480_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379555.1\|1258455_1259811_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340871
NZ_CP043612.1\|WP_111379557.1\|1259829_1260483_+\|beta-phosphoglucomutase	unknown	unknown	gnl\|CDD\|213672

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111379550.1\|1252386_1253994_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|380159	NF033071, SusD, starch-binding outer membrane lipoprotein SusD. SusD (Starch Uptake System D) is an outer membrane lipoprotein that binds starch and participates in a TonB-dependent nutrient uptake complex. Related proteins from similar TonB-dependent complexes that import other, usually multimeric nutrient substrates include RagB and NanU.	2.44035e-119
NZ_CP043612.1\|WP_111379646.1\|1245472_1246207_-\|type-III-pantothenate-kinase	gnl\|CDD\|237348	PRK13320, PRK13320, type III pantothenate kinase.	8.27264e-123
NZ_CP043612.1\|WP_111379544.1\|1246742_1248236_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.89307e-127
NZ_CP043612.1\|WP_111379547.1\|1248590_1251467_-\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|200488	cd11350, AmyAc_4, Alpha amylase catalytic domain found in an uncharacterized protein family. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	3.44341e-171
NZ_CP043612.1\|WP_111379541.1\|1243641_1244199_-\|LPS-export-ABC-transporter-periplasmic-protein-LptC	gnl\|CDD\|275202	TIGR04409, LptC_YrbK, LPS export ABC transporter periplasmic protein LptC. Members of this family are LptC, a periplasmic protein tethered to the inner membrane in the lipopolysaccharide (LPS)exporter transenvelope complex (Lpt), which is responsible for conducting LPS to the outer leaflet of the outer membrane in most Gram-negative bacteria. LptC is homologous to LptA, another member of the transenvelope complex. Genes lptC and lptA are often adjacent. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other].	1.64566e-22
NZ_CP043612.1\|WP_111379531.1\|1234584_1236756_-\|S9-family-peptidase	gnl\|CDD\|366374	pfam00930, DPPIV_N, Dipeptidyl peptidase IV (DPP IV) N-terminal region. This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.	2.80916e-118
NZ_CP043612.1\|WP_111379645.1\|1238344_1239253_+\|GHMP-kinase	gnl\|CDD\|224493	COG1577, ERG12, Mevalonate kinase [Lipid metabolism].	0.000432035
NZ_CP043612.1\|WP_111379553.1\|1257248_1258280_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	8.95613e-88
NZ_CP043612.1\|WP_111379536.1\|1239977_1242077_-\|peptidylprolyl-isomerase	gnl\|CDD\|372650	pfam13616, Rotamase_3, PPIC-type PPIASE domain. Rotamases increase the rate of protein folding by catalyzing the interconversion of cis-proline and trans-proline.	2.29393e-33
NZ_CP043612.1\|WP_111379558.1\|1260622_1262926_+\|glycoside-hydrolase-family-65-protein	gnl\|CDD\|237517	PRK13807, PRK13807, maltose phosphorylase; Provisional.	0
NZ_CP043612.1\|WP_111379549.1\|1251546_1252362_-\|hypothetical-protein	gnl\|CDD\|379544	pfam14292, SusE, SusE outer membrane protein. This family includes the SusE outer membrane protein from Bacteroides thetaiotaomicron. This protein has a role in starch utilisation, but is not essential for growth on starch.	1.43736e-17
NZ_CP043612.1\|WP_111379533.1\|1236936_1238250_+\|hydroxymethylglutaryl-CoA-reductase,-degradative	gnl\|CDD\|153082	cd00644, HMG-CoA_reductase_classII, Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR). Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR), class II, prokaryotic enzyme is a homodimer. Class II enzymes are found primarily in prokaryotes and Archaeoglobus fulgidus and are soluble as they lack the membrane region. Enzymes catalyze the synthesis of coenzyme A and mevalonate in isoprenoid synthesis. Bacteria, such as Pseudomonas mevalonii, which rely solely on mevalonate for their carbon source, catalyze the reverse reaction, using an NAD-dependent HMGR to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. Human and bacterial HMGR differ in their active site architecture.	0
NZ_CP043612.1\|WP_111379552.1\|1254030_1257012_-\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043612.1\|WP_111379538.1\|1242183_1243440_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	2.2045e-97
NZ_CP043612.1\|WP_111379555.1\|1258455_1259811_+\|MFS-transporter	gnl\|CDD\|340871	cd17313, MFS_SLC45_SUC, Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters. This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.45611e-83
NZ_CP043612.1\|WP_111379557.1\|1259829_1260483_+\|beta-phosphoglucomutase	gnl\|CDD\|213672	TIGR01990, bPGM, beta-phosphoglucomutase. This model represents the beta-phosphoglucomutase enzyme which catalyzes the interconverison of beta-D-glucose-1-phosphate and beta-D-glucose-6-phosphate. The 6-phosphate is capable of non-enzymatic anomerization (alpha <-> beta) while the 1-phosphate is not. A separate enzyme is responsible for the isomerization of the alpha anomers. Beta-D-glucose-1-phosphate results from the phosphorylysis of maltose (2.4.1.8), trehalose (2.4.1.64) or trehalose-6-phosphate (2.4.1.216). Alternatively, these reactions can be run in the synthetic direction to create the disaccharides. All sequenced genomes which contain a member of this family also appear to contain at least one putative maltose or trehalose phosphorylase. Three species, Lactococcus, Enterococcus and Neisseria appear to contain a pair of paralogous beta-PGM's. Beta-phosphoglucomutase is a member of the haloacid dehalogenase superfamily of hydrolase enzymes. These enzymes are characterized by a series of three catalytic motifs positioned within an alpha-beta (Rossman) fold. beta-PGM contains an inserted alpha helical domain in between the first and second conserved motifs and thus is a member of subfamily IA of the superfamily. The third catalytic motif comes in three variants, the third of which, containing a conserved DD or ED, is the only one found here as well as in several other related enzymes (TIGR01509). The enzyme from L. lactis has been extensively characterized including a remarkable crystal structure which traps the pentacoordinate transition state. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	1.31572e-76

>NZ_CP043612.1|WP_111379646.1|1245472_1246207_-|type-III-pantothenate-kinase
MILTVDVGNTRIKASVFEDNTALENFVFEKNELEKKIEKILEKYPKCSDLVVASVGNIEKQAFLTFENRLKVHFFTHEDVFPFHNKYATPKTLGIDRMILAAGATLQFPKQNRLVIDAGTCITYDFIDENDNYLGGAISPGLRLRYESLHNFTARLPLLTLEEPDSYVGNSTAQAIHSGVVNGFVYEIDGFIDEYRKEFSNFIIILTGGDADFLAKRLKNTIFANSNFLLESLSQTYQYKIDND
>NZ_CP043612.1|WP_111379543.1|1244250_1245480_-|hypothetical-protein
MIKKVILSACLLISFVSFAQQGTASPYSFFGIGDVRFKGTLENRSMAGVAIEQDTIHLNLENPASYASLIQTTFTVGGTFATSNLKTTSASEKAQRSTFDYLALGIPMGKFGASFGLIPVTSVGYKIRNDNSATEGATSSQLDGKGGVNKVYFGLSYKIMNDWNIGVDAQYNFGKITTTSIEAVTGVQNGTAEVNTSELSGMAFSFGTMYQRKIYKKMSLFSSLSYSFASDLNSDNTRVISVQGDPDPYVVPTESTKLKLPNKLSIGFGVGEARKWLVGANMTFQGDGQLGNYYNAADNVRYESYSKYALGGYYLPNYTSFTSYMSRITYRAGLKYEKIGLIVNNESIKDIGMSLGAGIPIPGSFSNVNFGIEFGKRGTTAADLVQENYVNFSLSFSFNDKWFVKSKYQ
>NZ_CP043612.1|WP_111379541.1|1243641_1244199_-|LPS-export-ABC-transporter-periplasmic-protein-LptC
MNLPKRYSLIAVTVFAVTLFFGCESNFKEVQKINFSEFVPASDADTVNIKYTDSGHITGILISPKMLDYSNLDFPFTEFPKGIDVTLYDKKQKRTFIKGNYAVSYKNTGIIDLIGKVKITSEAGQILETEQLYFDQKNEWFYTERKFKLTDIKGVSYGQGIDFSKDFKVINSQRISGEIESNEEL
>NZ_CP043612.1|WP_111379539.1|1243442_1243637_-|hypothetical-protein
MGYLKYTQYVYILFAVFFTYDGIVKLNEGDESYPFYFVIAGMAVFMFFFRRRFLNKHNDRNKNQ
>NZ_CP043612.1|WP_111379538.1|1242183_1243440_-|HlyC/CorC-family-transporter
MGISIIIICLILAAFFSGMEIAFTSANKIYLEIEKKQDDFLSRILTKLTENPSKFIAAMLIGNNVALVIYGFFMGDLILGWMAYFGLVFSDWWNILIQTLLATFVVLLTSEFFPKVFFQIYANSLIKILALPAYLFYRLFYYISTFFIWIADFVLSKFFKTEGNQIHLFSRIELGNYITEQMSTVEEDEEVDSEIQIFQNALEFSNVKARDIMTPRTEIVDIDLFDTVDDLKALFIETGYSKIIVSQNSLDDIVGYVHSFDLFKKPATIKSVLMTVEFVPETILIKDVLNLLIKKRKNVAVVLDEYGGTSGIVTIEDIVEELFGEIEDEHDLDEELIEEEIGEGKYLFSTRLDVEYLNETYKLMIPEEDSYGTLGGFIVHHTKEIPQKGDKIVIDKFHFFIEEASNKKIELVKLTIKE
>NZ_CP043612.1|WP_111379536.1|1239977_1242077_-|peptidylprolyl-isomerase
MAVLAKIRQRSALLIGVIALALFAFIIQDLFTRGTFGQSSKDVGSIDGKDISFEDFRVKVSNVEKSGQGITSTEAANRVWDQEVSIALLSSQFDKLGLRVGEKHILEVLKSDPNIGKNPMFLNAAGMFDVVKFKDYFKSNPEAAQYISQKEKDAELNAKFQIYNTLIKSGLYTTASEGKLKYEMETNKVSFAFAAAPYSSIKDSEVKISDDEIVAYMKKNEKKFKADATREIQYVLVEDKASKEDEAEIKAKLTALLSGSVVYNAKTGKNDSLPGFRSATNIAEFVNANSDVPYDSTYVPKNALPAVDADKLFSLPAGAIYGPYVYGRYYAISKSQGFKAGVNAKASHILIGYEGSQTPNPKEKRTKEEAKAKAEEILAQVQANPDSFMMLAFTSSDDSSAQQGGDLGYFGPNQMVKPFNDFVFSNGIGKVGLVETPFGFHIIKITDKQDGIRLATIAQKIEPSEATSDKVFTLATKFEMDAADKDFNAAAKELGLKVAQPVNAKAMDEAFGSLGNQRNIVRWAFDKETSKGDVKRFEIANIGHVIAQYKGENKSGLVSVDMARPYVEPILKNKKKAELLKAKMQGSSLEAIAKAAGVAVQQAADVTLDNPVLPGGVGQEPRVVGNAFALTANKISAPIEGNTGVYVVKNIKTVKAPAIANHAAYVEKVKAQSASDVNRVLPALKNNAKIEDNRLQFNY
>NZ_CP043612.1|WP_111379534.1|1239271_1239712_-|hypothetical-protein
MFFTFKFFRKKPRVYTKIESHIYGIITELLKVSSTDINVDELGGKYYLSNEEQHFKVTILSNDYVIRLTNTHDSVAEKYDKVFVEDVLKAVKEEKHRRMEVVYDSITNSIEKMAERLHNRLIESNEQDKSVRRLETKEVKSSKKVN
>NZ_CP043612.1|WP_111379645.1|1238344_1239253_+|GHMP-kinase
MPTTFYSNGKLFIAGEYLVLDGADAFALPTKFGQNLVIEDSEDKQIEWKSYDYDKHLWFEETILFDEVIKGSDPQIDTVKSTLVNILHEAYILNPKFIDNANGYKVSTHLSFPRNWGLGTSSTLINNIAQWTEINAFTLLKNSFGGSGYDIACAQNNTPVLYRIKDNFVQQVEFNPDFKEHLYFVYLNKKQNSKSAIYSYNNHKGNHLAANIAENNKITNEILHAKTLKEFAAAIQKHEIHLSKVLEMQTIKEAVFPDFNGVIKSLGAWGGDFILVVSKEDPKEYFFNKGYETILTYEEMIL
>NZ_CP043612.1|WP_111379533.1|1236936_1238250_+|hydroxymethylglutaryl-CoA-reductase,-degradative
MNNAVAGFSKLSKKEKINWIANEYFSNPEEAQNIIRNYWNSDEKLQQLHDEFIENTITNLYIPLGVAPNFLINGKYKTIPMAIEESSVVAAASKAAKYWSTRGGFKATIIDTEKIGQVHFTYSGDAEKLTQFFNQIKPKFFSETQSITKNMQQRGGGILDIKLKDKRSLLENYYQLHATFETKDSMGANFINSCLEQFATTLKEEGQNSDLCQNGEKLEVIMSILSNYVPHCLVRAEVSCPIEDLAEKHITNPQEFAERFVQAVQIAEVEPFRAVTHNKGIMNGVDAVILATGNDFRAVEAGVHAYASRNGQYASLSHAKIENGIFTFWLEIPLAVGTVGGLTSLHPLVKLCLEILEKPSAPELMEIVAVAGLAQNFAALRSLTTTGIQEGHMKMHLNNIINQFEATDEERHLIKSHFKKTAVSHSAVVEFIESLRK
>NZ_CP043612.1|WP_111379531.1|1234584_1236756_-|S9-family-peptidase
MNTSKFTAVLLFLTAVVFGQQKITVENVFSGTFRAKGMDELQSLKNTNQYTVLNVDQASRSMQIDLYDFATLKKVSNLIDTKSFKELAEGIDSYTFDASEKKILIACHSSKIFRHSFTADYFLYDIAAKSLTKLVDFQIQEPTFSPDGTKIAYARENNLYVYDVASKKSTAITTDGKKNAVINGITDWVYEEEFAFVRAFDWSKDSKKVAYIRFDESQVPEFSMSIFHKDLYPKIETFKYPKAGEKNSDVSLHIYDVAAGATKKVNLGNYNDFYIARMQWTNDANVLSAQVLNRHQDNLDILFIDGNTATSKVVLNEKDKAYVDITDNLTFLKDNSFIWTSEKDGFNHIYVYDKNGKLKNQVTKGNWEVVSYYGFDEKTKTIFYQSTENGSINRDLYRIGLDGKNKVRLSSKTGTSAATFSPNFQYFIATFSSNTQPTTYTLNEAKTGKEIQVIENNQALADKLKAYDLPSKEYFVLKTAKGNELNAWILKPKDFDPSKKYPVFMFQYSGPGSQQVANQWNNSNDYWFASLTQQGYIVACVDGRGTGYKGADFKKVTQKELGKYEVEDQIDAAKVIGAYPYVDASRIGIFGWSYGGFMASNCIFQGNDVFKMAIAVAPVTNWRFYDSVYTERYMQTPQENASGYDQNSPINHVDKLKGKFLLIHGSADDNVHVQNTMQMMEALIQANKQFDSQIYPDKDHGIYGGKTRVQLYTKMTNFIKENL
>NZ_CP043612.1|WP_111379544.1|1246742_1248236_+|MHS-family-MFS-transporter
MSKTSTKGIWKVISASSMGTMIEWYDFYIFGSLAVVISTKFFPSDNPTAAFLSTLATFAAGFVVRPFGALFFGRLGDIIGRKYTFMATLLLMGGSTFLIGCIPSYETIGFLAPLLVLILRLLQGLALGGEYGGAATYVAEHAPAGEKGYWTSWIQTTATVGLFISLMVILATKSILSAEAFDLWGWRVPFWVSIAMVGVSYLIRKNMDESPVFAKAKKEGTTSTNPLKESFGNRYNLKFVLLALFGATMGQGVVWYTGQFYAMSFMKTVMNIDSSQVDELLGIALLIGTPFFIVFGWLSDKVGRKYIMMFGMLIAILSYRPIYKVMYDTTDISKKTEIPETPRISTENKADGSSVTITEKKYTDGTSVVEKKTYLNKKDTQTSVSILINSSDKWTLTFLVFIQVLFVTMVYGPIAAFLVEMFPTKIRYTSMSLPYHVGNGIFGGLLPAISTYFVSHAKTAGKTDFYLDGLWYPIIIAGICFVIGMIYIDNKNKTTHL
>NZ_CP043612.1|WP_111379546.1|1248246_1248480_+|hypothetical-protein
MNAIKQVLGALWIALAAAAAYFCVFEFGLPKLLSDQQDDLVFGAIILFILTPLIVMGLGTFGYYSLIGEYNDTKRKK
>NZ_CP043612.1|WP_111379547.1|1248590_1251467_-|T9SS-type-A-sorting-domain-containing-protein
MKKTLLFIFFLLSIIAEAQQITVSPAVFQVNQQIKITASFASSTCNTMGTSPTKVYMHAGIGNEANPWQVVKGNWGADDGVGLMTKETNGTWSITITPSVYFGLTATQQTAATKMGIVFRNANGSQTLKLAPSCSDFFVNVGSFQVTLTSPAENSTTIINSGSSFAISATNSGGAGSYTLKSNGTTINTNASTSSYSYTHTNITGNQSYELIATQGTTTVSKKFAVVVNPNTISEAMPAGLVDGINYNPTDFTKATLVLDAPLKDFVYVAGSFNNWQPTSAYAMKKDPATGKFWLELTGLVSGVNNTYQYWVVDTTPIANSPSMVKTADPYSTLVLSPYDDPSIPASKYPNMPVYPIGQNFEVTVLKTGQTPYNWQVTNFEKPEKEKLVVYEVLVRDFDASRSYQSLIDRIDYFKNLKINAIELMPVMEFEGNESWGYNTSFHMALDKFYGTSDKLKEFIDLCHQNGIAVILDVALNHAFGRNPMVRMWMNDPDGDGFGSPTAENPYFNTVAKHSYSVGEDFNHQSLKTQYYVNRVIKQWIQEYKIDGFRWDLTKGFTQSCTAGDNACTDGYRQDRVDILKKYADFSWAVDPTHYTIFEHLGTDAEEKEWANYRVTETPSKGVMMWGKMTKEYNQLSMGYASESNIYRMNSANRGFAANRLMGYAESHDEERLMYKNVQYGAVNGSYNVKTLNTALSRMSAIGAVSLLIPGPKMIWHFGELGMDDSIFSCNNGTVNDETTTTPGDCKLDTKPQPQWTENWLGDSNRNKIYNDWAKMITLKKTEPVFLGTATMNNAATLAVNIKITNSSLTSAQLKDVLILANFGTTAQNIATGFPYAGTWYNLMDNTTITVTDVNAPVNLPAGEYRIYGNKVANLAIEDFEKGNSVNLYPNPVSDYFTLNAGFVKVQIYSVSGQLVKSFNSNGTSDSQFGVSELQSGLYIVKASDENNKTQVMKFIKR
>NZ_CP043612.1|WP_111379549.1|1251546_1252362_-|hypothetical-protein
MKNIYKILIAFIGVLAVSCNADDVEERPVITPESTPVLLSPQNDFNIVLTKENEKEIATTVIWDYAKYAGTATVINYTIEIAKAGTKFAAPIAVTTTTERYRALTVAELNSALINGGFIEKEENNVDIRIKATVGTGAEAQYSNFYTFKATPYHTPLATSHWLVGAATPGGWTWDGDAETEFPLVVGKTDVYQVTVVLKSGEAFREFLGNNFTSNGNWDASHNYSYYSGLGYTIDDELVNAGDGDSNFKYTGPTGPRVLTIDNGAKKITLD
>NZ_CP043612.1|WP_111379550.1|1252386_1253994_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKISFKYISYFLLFILGLSMTLTSCTSDLDVKPTDDDEFLSDDFFQDPASYKQVMAKLYAGLYVGGNDGDGQADISGLGGDFSSYLRLLFVTQEFPTDEAIVAWSDDGLPAINGQKWSPSNQFLYGIFSRAFYEISVANEFLRQTTDEKLTQRGVDAKLKAEVTTLRAEARFLRAFSYVNLMDLFGNVPITTENDPVGYYFPEQKTRAEVFAFVESELKDMDATLAPSGSNEYGRVDKTAAKFLLAQIYLNSKVYTGTERYNDVATICNEIVTGSAYTFANVPYRYLFSADNNRNGAQSEVIFPIVGDGNAIRAIGGGMSFILHASIGGKMVSADQGMDGGWSGIRTRPEFVQLFPDVNAASDKRGTFFTDGQTLDIADYGVFSNGYAVTKFTNVNSDGSKAQRPDMPDTDFPMYRLSDVYLMYAEATLRGASSGNMTLALEYVNKIRARANAGLITNSELTLDFLLDERGRELFWECHRRTDLIRFGKFTGSSKIWQWKGGVKNGSGTDSFRDLMPIPSRTIQANPTLKQNPGY
>NZ_CP043612.1|WP_111379552.1|1254030_1257012_-|TonB-dependent-receptor
MKTIYKKLLFLFLLLPFTVLAQNTLKGTVVDKTTGQPIPGVNVNVQGAPNGASTGFDGNYQLSNVKNGNKIVVSFIGYKTETIEYTGQKTLNVTLEEDTNQLKEVVVQVGYGTVKKKDATGSVSQIAAKDFNKGINVTPETLISGRIAGVNVVGGGAPGAKADIRIRGGSSLSASNEPLIVIDGLPMSNSVPDGATSVLSTIDPNDIESFTVLKDASAAAIYGSRAANGVIVITTKKGTKGGVKVNFSSQVGINTVANTVDVMSADEYRAIVNANGTPAQKALLGTANTNWQDEIFHTALTTNNNISVSGSLFNKLPVRLSVGNVDNPGILMNTSFERTTTSLSLNPVLFDNHLKIDITGNLAFGKNQFQNEGAAISSAIIFDPTQSVYQEGSRYGGYFEWLEANGNVPLLPARNPVARINQEDRRATSTRKWGNIRLDYKFHFFEDLRIVAEAGIDKFDSDGYNAISTESILGYQPNTFDKGNWVNLGGYTHYTDTRQNKNLNTYFNYTKDIGKFKIDATAGYNYQLFQREGFNSGDIKQPNPPADVTTDADVNLQSYFGRLNLGYDSRYLLTVNYRRDGTSRFSKENRWGNFAGGAFAWNLAEEAFLKDNETLSSLKLRVGYGTTGQQDIPRAYDYLQRVTLGTLNTQYVFDGVIYRAARPEGYNKDIKWEDLAEMNIGVDFGFFNERLTGTLNYFDKKSSDLLADIPVPDGANIRNQGYSNIGSVRTKGVEFSLQSDIIKNDKLTWNVAANVTYIDQKISDLGVTVPGFQGYITGDVIAGGTGNQVLIHSEGYAPNSFFVFEQLYDANKRPIQGAYADRNGDGVITDADRYKYHKPTADYTFGLYSTLNYKKFDFTMNWRASLGNYIFDNVSSDKGYLQAGLRRDSDLANITTDYYNTGFTTESNSNGTQRNYSNYYVKDASFIKLDNIVLGYTFDKTLLKAASLRFTAGVQNVLVFTKYNGLDPEKFNGIDNNVYPRARTFLFGVNANF
>NZ_CP043612.1|WP_111379553.1|1257248_1258280_+|LacI-family-DNA-binding-transcriptional-regulator
MKRKITLKQIAKELDVSISTVSKSLRNSLEIGEETRLKVQAFAKFYNYKPNNIALSLKNRKTKSIGIIIPEIVHYFFSTVINGIEQVANEYGYSVVICVSDDSFDKEVLNMEMLANGSIDGFIMSLSKETQYKGDFHHITEVINQGMPVVMFDRVTNDILCDKVIIDDKSAAYEAVQSLIDSGRKKIALVTTVDYVSVGKLRTDGYEKALLDNELPFNEDLIIKIEDVDTCEITISELLHARAFDAVFAVNELFAVTIIKTANKMGLKVPEDLAVIAFTDGIISKYSTPTITTVSQSGEKMGNKAAKMLIERIEAEEDDDEEHNENYITEVIETHLIKRESTD
>NZ_CP043612.1|WP_111379555.1|1258455_1259811_+|MFS-transporter
MEKRKLSFWEIWNMSFGFLGIQMGFALQNANASRILQIFGADVHELSWFWIIAPLMGLIVQPIIGHYSDKTWGRFGRRKPFFLVGAVLASVGLILMPQANIFISVLPALWVGAGMLMIMDASFNIAMEPFRALVGDNLRTDQRTAGFSIQTSLIGFGAVIGSALPYILTKYFGVPNSTVPGSVPLNLTLSFIIGAAVLIGSILVTLFTTKEYSPEELAKFEDPQNDAIPDSEEKSKITDIFTDFAKMPVTMRQLSWVQFFSWFGLFGMWVFTTPAIAHHIYGLPLEDTSSQQYQDAGDWVGILFGVYNLVSAIVALFFLPYIAKKIGRKATHSLSLIIGGIGLISIYFMPNEDWVVLPMILIGVAWASILAMPYAILAGSITPKKMGVYMGIFNFFVVIPQIVNALIGGPIVKYLYNGDAIYALVTSGVSFLIAAALVSKVKDVDDFTQKS
>NZ_CP043612.1|WP_111379557.1|1259829_1260483_+|beta-phosphoglucomutase
MSKKAFIFDLDGVIVDTAKYHFLAWQKIAKSLNINFTHEDNELLKGVSRVRSLDIILGLGNVQATQEQKDQWLIQKNEDYLSYLVDMDESEVLPGVLKILKLLKEKNQGIALGSASKNARPILEKTGVLSYFDVIVDGNDVSNAKPDPEVFLKAAQLLNIDPKNSIVFEDSVAGIQAANIGEMVSVGIGEETILHEADYIFKDFTQIETSFIEQLIG
>NZ_CP043612.1|WP_111379558.1|1260622_1262926_+|glycoside-hydrolase-family-65-protein
MNQDYIKPDNWSIIEEGFDAERVKSSESLFSIGNGAMGQRANFEETYSAETFQGSYIAGIYYPDKTKVGWWKNGYPKYFAKVLNAPNWIGIDIEINEENLDLNTCTEVRNFRRELNMKEGWYNRSFEAVLKNGTEIAVNVRRFLSLDLDEAGVIKYDITPLNKDAKIVYKPYIDAGVTNEDANWEEKFWEPLEVKKGTNEAFVTAQTFKTHFKVTTFMHNTILANGENINVSPSTIDSTVDKVQYTYGTIIAKGQTSTIQKIGGYTVSLNHENTLAGAEKVIKSAVALGYDTLLQNQIDAWAKIWEMSDITIEGDVKAQQGIRFNIFQLNQTYSGKDSRLNIGPKGFTGEKYGGSTYWDTEAYCIPFYMATKDQQVARNLLTYRYNQLDKAIENAKDNLGFKNGAALYPMVTMNGEECHNEWEITHEEIHRNGAIAFAIYNYNRYTGDYSYIPEKGLEVLIGIARFWHQRASFSKDKNQYVILGVTGPNEYENNINNNFYTNYIAKWCIDFAAEQIEKVASEYPADHKRVMDKVNLSAEEIKEWKKVADDMYFPISEELGIYLQQDGFLDKDLVPVKDLDKSQRPINQKWSWDRVLRSPYIKQADVLQGFYFFEDHFSKEELKRNFEFYESFTVHESSLSPCVHSIQAAALDKMDMAYTFYLRTSRLDLDDYNKEVEEGCHITSMAGTWMSIVEGFGGMRVKNDQLHFSPKIPKEWNGYSFKINFRNQILKVAVNHNETTFTVDGDQDLTIIVNGNPVTASKFVQIN

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Crispr_ID: NZ_CP043612_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_4

1311573-1311673

Orphan

Consensus_repeat	Method
AGATTTCTCGTTCCTCGAAATGACAATAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_4

>merge|NZ_CP043612|4|1311573-1311673|CRISPRCasFinder
AGATTTCTCGTTCCTCGAAATGACAATACTTTATGGTTACAATGCGGAAAAAACTTTGCAGAGTTACTGCGAAGATTTCTCGTTCCTCGAAATGACAATAC

>NZ_CP043612|4|4|1311573-1311673|CRISPRCasFinder
AGATTTCTCGTTCCTCGAAATGACAATAC	TTTATGGTTACAATGCGGAAAAAACTTTGCAGAGTTACTGCGA
AGATTTCTCGTTCCTCGAAATGACAATAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_162615449.1\|1324588_1325020_+\|DUF4625-domain-containing-protein	unknown	unknown	gnl\|CDD\|379723
NZ_CP043612.1\|WP_111375853.1\|1323789_1324140_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111375844.1\|1311029_1311269_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379619.1\|1305476_1306439_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379618.1\|1305105_1305480_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP043612.1\|WP_111379651.1\|1303885_1305028_-\|M56-family-peptidase	unknown	unknown	gnl\|CDD\|320700
NZ_CP043612.1\|WP_111379615.1\|1301764_1302151_-\|DUF423-domain-containing-protein	unknown	unknown	gnl\|CDD\|225238
NZ_CP043612.1\|WP_111379613.1\|1299858_1301463_-\|phosphoenolpyruvate-carboxykinase-(ATP)	unknown	unknown	gnl\|CDD\|236471
NZ_CP043612.1\|WP_111375846.1\|1312832_1313495_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|223710
NZ_CP043612.1\|WP_111375848.1\|1316455_1317811_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455
NZ_CP043612.1\|WP_111375843.1\|1309334_1310747_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111379621.1\|1306458_1306881_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111375845.1\|1311931_1312723_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111375849.1\|1318082_1318904_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP043612.1\|WP_073408088.1\|1307666_1309055_-\|dipeptidase	unknown	unknown	gnl\|CDD\|349929
NZ_CP043612.1\|WP_111375851.1\|1320132_1321059_-\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_CP043612.1\|WP_073408093.1\|1315326_1316376_-\|HlyD-family-secretion-protein	unknown	unknown	gnl\|CDD\|224482
NZ_CP043612.1\|WP_111379616.1\|1302338_1303703_+\|saccharopine-dehydrogenase	unknown	unknown	gnl\|CDD\|379865
NZ_CP043612.1\|WP_111375852.1\|1321055_1323632_-\|peptidase-M1	unknown	unknown	gnl\|CDD\|341065
NZ_CP043612.1\|WP_111375847.1\|1313741_1315325_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_162615449.1\|1324588_1325020_+\|DUF4625-domain-containing-protein	gnl\|CDD\|379723	pfam15418, DUF4625, Domain of unknown function (DUF4625). This family contains a likely bacterial Ig-like fold, suggesting it may be a family of lipoproteins.	4.85369e-24
NZ_CP043612.1\|WP_073408093.1\|1315326_1316376_-\|HlyD-family-secretion-protein	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	2.78612e-84
NZ_CP043612.1\|WP_111379618.1\|1305105_1305480_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	1.00972e-28
NZ_CP043612.1\|WP_111379613.1\|1299858_1301463_-\|phosphoenolpyruvate-carboxykinase-(ATP)	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	0
NZ_CP043612.1\|WP_111379615.1\|1301764_1302151_-\|DUF423-domain-containing-protein	gnl\|CDD\|225238	COG2363, COG2363, Uncharacterized small membrane protein [Function unknown].	5.5091e-22
NZ_CP043612.1\|WP_111375846.1\|1312832_1313495_-\|HAD-family-phosphatase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	2.13281e-55
NZ_CP043612.1\|WP_111375848.1\|1316455_1317811_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	8.3515e-24
NZ_CP043612.1\|WP_111379651.1\|1303885_1305028_-\|M56-family-peptidase	gnl\|CDD\|320700	cd07341, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	5.26907e-19
NZ_CP043612.1\|WP_111375849.1\|1318082_1318904_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	7.6449e-31
NZ_CP043612.1\|WP_073408088.1\|1307666_1309055_-\|dipeptidase	gnl\|CDD\|349929	cd05680, M20_dipept_like, uncharacterized M20 dipeptidase. Peptidase M20 family, unknown dipeptidase-like subfamily (inferred by homology to be dipeptidases). M20 dipeptidases include a large variety of bacterial enzymes including cytosolic nonspecific dipeptidase (CNDP), Xaa-methyl-His dipeptidase (anserinase),and canosinase. These dipeptidases have been shown to act on a wide range of dipeptides, but not larger peptides. For example, anserinase mainly catalyzes the hydrolysis of N-alpha-acetylhistidine while carnosinase degrades beta-alanyl-L-histidine.	0
NZ_CP043612.1\|WP_111375851.1\|1320132_1321059_-\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.90757e-25
NZ_CP043612.1\|WP_111379616.1\|1302338_1303703_+\|saccharopine-dehydrogenase	gnl\|CDD\|379865	pfam16653, Sacchrp_dh_C, Saccharopine dehydrogenase C-terminal domain. This family comprises the C-terminal domain of saccharopine dehydrogenase. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase.	3.54242e-93
NZ_CP043612.1\|WP_111375852.1\|1321055_1323632_-\|peptidase-M1	gnl\|CDD\|341065	cd09602, M1_APN, Peptidase M1 family including aminopeptidase N catalytic domain. This model represents the catalytic domain of bacterial and eukaryotic aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
NZ_CP043612.1\|WP_111375847.1\|1313741_1315325_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	7.11408e-21

>NZ_CP043612.1|WP_111375844.1|1311029_1311269_-|hypothetical-protein
MNAKNLSKETEKRLLDFFNNVIDAKDLAKAIRQLNYAIALVVMKDDERGYVYAQRENLEKGFYWLNELAEILHPYLEVE
>NZ_CP043612.1|WP_111375843.1|1309334_1310747_-|hypothetical-protein
MIKVYIDWNVMSGMKNGNFSELKEIFKDKNKFSLMYSTSHIGDILASNRDDQAQQEIIQQDLDFITNLTDNLCLANSGKEVYFDYLDPRELFENQMESNKLTDDLSIDNLFDFKNNDESLNEILESNKELLKNTSLDPAFKAIYDTPEGAEFMNKLFPGLENDLSMDGFFKSFGLMLKNLNEKEGLKDLRAIVQNVGVNSSHFNPDKNPFDLIEGAYKKNGFVDFRNNYIEKGKNAPLWFDEITNEYILLDLHGFNSDKIKVNDKEKNTFRNTTEDASHSAFATLSDFYITNDVKNLKKTKAVYEKLEILTKVLKPDEFLEYFKTYLDFNSILDHFDSISIAFKKRDLFRMEFNDEKLTSLTQFSNYYFFNFFNKIILSFNIIDKNRGGFILCKELPSKHFQIDFVDVEKLVKIFVENYGVDNNGKGYLRKEEFVEGNWAGRCWLLESNYIKITQANYFFQLYFYPLEKG
>NZ_CP043612.1|WP_073408088.1|1307666_1309055_-|dipeptidase
MENIKSYVQQHKDRFINELIELLKIPSVSADTAYSQDVIDTAEAVKESLSKAGCDYVETCDTPGYPIIYGEKIIDPNLPTVLVYGHYDVQPPDPLELWTSPPFEPVIKTTDIHPEGAIFARGACDDKGQMYMHVKALELMVQSNTLPCNVKFMIEGEEEVGSASLAWFVERNQEKLKNDVILISDTGMISNQQPSITTGLRGLSYVEVEVTGPNRDLHSGLYGGAVANPINILAKMIASLHDENNHITIPGFYDKVEELSAEERAEMAKAPFSLEKYKNALNIEDVYGEKGYVTNERNSIRPTLDVNGIWGGYTGEGAKTVIASKAFAKISMRLVPNQEWEEITELFTKHFTSIAPAGVTVKVTPHHGGQGYVTPIDSIGYQAANKAYTETFGVPAIPVRSGGSIPIVALFEKELKSKTILMGFGLDSDAIHSPNEHFGIFNYLKGIETIPLFYKYFVELSK
>NZ_CP043612.1|WP_111379621.1|1306458_1306881_-|hypothetical-protein
MKNLFLLLFCGSMLLSCKSKPINQKIDRKKEGVWIDDYTQDGTNYKSYEYYKNDLPIKKWKSYINGKIYKTEKYKNGICVVKSYYENGKLESKGKTKLETNSVETHWFYFGEWKFYSDKGKLKGIKNYEKGELISEQNIK
>NZ_CP043612.1|WP_111379619.1|1305476_1306439_-|hypothetical-protein
MKRIIAFSFIVFNCVFMQAQTYKEWVHKADSCYTAKNYKLSVSYYEKAFKIEKKDNRDLYNAGCSASMARQHKKAFKWLNLSIDNGYENMAHIKIDNDLKPLHSEKEWNKTIDKLQKKLDVIGANYDKVLEKQLAEIYTEDQEIRGEFMNVYRAAKPDKKKIDSIGKIMERKDSINLIKVMKILDERGWLGKNVVGTQGNQTLFLVIQHADLEYQQKYLPMMREAVKNGNANPGNLAYLEDRVALREGKKQIYGSQSSKNKKTGKICIAPMIDPDNVDKRRAEVGLGTMADYAVKLNIDWNLEEYKKELAETEKLENTKP
>NZ_CP043612.1|WP_111379618.1|1305105_1305480_-|BlaI/MecI/CopY-family-transcriptional-regulator
MIQLSNAEEQLMEHLWKLEKAFMKDLLEAYPEPKPATTTVATLLKRMIDKKFVAYNEFGNSREYYPVVKKTDYFAKHVKGLISNFFNNSASQFASFFTTETNLSSSELEDLKKIIDSEIQKKKK
>NZ_CP043612.1|WP_111379651.1|1303885_1305028_-|M56-family-peptidase
MFRFNRAYLLGSLIFSFIIPLQLFTFKPLFESGLNAIQLEGIEIRTSRAPIDENYILEYVFAILKRVYVIVAIVLGFRLILNVLSFFQKLRSKEALSVNGVKVILTDDAVLPHSFWNAIFVNKTEFETGRVPSELIVHEKAHLEQRHTLDILFIATVQTVFWFNPFISLFRKAIKLNHEFLADEAVNKQFGEVKNYQNLLLQFASNKKTVDLASNINYLITKKRLLMMTKEISPIAMILKISSVAAVCFLLLIAFNSEAVAQTSANLRNQNNKGINYVGANVGKPQFPGGIEKFYMFVGQNFRMSEEFSKQKIQGKFLIEFMVEKDGSLSDFKVVKDLGYGTAEEAIRVLKLSPKWIPATENGQAVRVMYSLPITLQSEK
>NZ_CP043612.1|WP_111379616.1|1302338_1303703_+|saccharopine-dehydrogenase
MRNILIFGAGRSASSLIRYLLSKSNEEKLHLTVADLSLNLAKAKTQEHPNATPIALDIFKSDERKKAIENASIVISMLPAHLHIEIAKDCLEFKKHLVTASYISDAMQALNEEAIQNNLIFMNEIGLDPGIDHMSAMKVIDEIRSKGGKMLLFESFCGGLVAPESDNNLWNYKFTWAPRNVVLAGQGGAAKFIQEGTYKYIPYSALFRRTEFLEVEGYGKFEAYSNRDSLKYRSVYGLDDVLTLYRGTIRRVGYSRAWNMFVQLGMTDDSYVLEGSENMSYRQFINSFLPYHPTDSVEIKTRLILKIDQDDIMWDKLLELDLFNPNKKVNLPNATPAQILEKILSESWALEPDDKDMIVMYHKFGYELNGEKKQIDSKMVCIGEDQTYTAMAKTVGLPVAIATLLILNGKITTPGVQLPIKKEVYEPILKELEEYGVIFNEQNVPYFGYNPDLF
>NZ_CP043612.1|WP_111379615.1|1301764_1302151_-|DUF423-domain-containing-protein
MKRRIILTGAFIGMLAIILGAFGAHLLKKYLSVDQLNTFEVGVRYQMYHALFLLFLSTQKDIAEKTLKTIYNLVVAGVLLFSGSIYLLATKDYTLFESKIIVFATPLGGFLLIIAWTLLFFAILKRKS
>NZ_CP043612.1|WP_111379613.1|1299858_1301463_-|phosphoenolpyruvate-carboxykinase-(ATP)
MDSNTVFAQSISLKELGIENAKVRYQLSADELHAITLQSGQGVENSTGALAINTGEFTGRSPQDRFIVKDDITKDQVWWGNVNIPFEPQAFEKLYNKVTAFLSNKEVFVRDSYVCSDPNYRLNVRVVTETAWSNLFCYNMFLRPEDSELANFTPEWTVVCAPSFMADPAVDGTRQSNFAILDFTKKIALIGGTGYTGEMKKGIFSALNFILPVFKNTLPMHCSANVGEAGDTAIFFGLSGTGKTTLSADPERKLIGDDEHGWTNENTVFNFEGGCYAKVINLTEENEPDIFRAIKKGALLENVVFKAGTNVVDFDDVSITQNTRVSYPITHIDNVQPGLIGHNPKNIFFLTADSFGILPPISRLTPGQAAYHFISGYTAKVAGTEAGVTEPQPNFSACFGAPFMPLHPTRYAEMLSKKMKDAGVKVWLINTGWTGGAYGTGSRMKLKFTRAMITAALKGELNDVEFKNHEVFGIEIPQDCPNVPVEILNPRNTWEDKDLYDKKALELAHKFKANFAKFEEFANAEILAGAPITE
>NZ_CP043612.1|WP_111375845.1|1311931_1312723_+|hypothetical-protein
MRKYRLLVILLAIIAVFYFTRTVRSFTVQHETKTLKSEHFIVSYNGIYKSEAKKVNKHLEENYSRIRENLKDIDHDPIKVFVYGSQFKFNEATGLTENTKGTSRGPNEFHFVWTNWFNSIFPDDPLKTALHEFTHCVQLNILIHKAKDIIITQDRMTFEREFDKKFKAEYPRWLWESISIFEAGEVNSLSVKYAKSKNLTLEDLNHGNQIYNIGYTIIEYMTQKWGKDILPKLIASFGNIQKTLNVTQEEFEKGWMAFLKEKY
>NZ_CP043612.1|WP_111375846.1|1312832_1313495_-|HAD-family-phosphatase
MSQQCVIFDMDGVISHTNPHHVIAFEKFFDKYNIPYTREEFEEHMYGKHNSYIMTHFFKRPIAGEELIRLEDEKEGMFREIYKDKVETIPHYIDFLNELKSRGFKTAVATSAPRANLDLIANALKLDEKMDSMMSSEDVTFHKPNPEVYLKSAERVGVSPSDCVVFEDSFSGITAGLNAGMKVVGVLSTHTKEQLPPCDFYINDYSEVNVDKILEILGKK
>NZ_CP043612.1|WP_111375847.1|1313741_1315325_-|MFS-transporter
MEDKSIFKSWVPKWAIITILFVCLLHSMILLGVYTSNVTYAASFLDIEPEDLQYAMCVTYGTLLATILIESRFSSFFPAKNYLMGVYSLIGVTIVTSGYVDNFAVFLLLRVAEGILMALPAITIRQLLIEQFDSKNAIIIGFSFYYGSLLLSTPFIMNIAVWFLDHYDWKYMLYVSGGLQVLNVFLILVTFRGHRTTKKIPLYQIDWMSYFLVLTAILCGAYFFVYAEKKYWFESSQMVLMLITALITGGLFIFKELLVKRPTFNFEVFKYANLRIGFLLFFLFYISRATLSLCHSAMYSIWNWDPSRVAGVQYINGLGNIIGLVLAAFFLMKSLSTKIIFLIGFSLIALYHFWFTFLFVPDVALSDIIVPYFLQGIGVGLLFVPLILFTTSSVPANMAVSSGIVGVSGRFWGSTIGFCVMQNATVFLNKKHFMKLSQFVTGENPEAQQNIANATQSFIAKGYSADNANVLAMKKIFGSIAKQSTLLADMEIYTIVGYGLLVLIILIACNQHLRQTMTLVKSKIWIG
>NZ_CP043612.1|WP_073408093.1|1315326_1316376_-|HlyD-family-secretion-protein
MVKIKNETRRNKTFHILITIIACVLVISGVILGIWFYVFNRNHEETNDAQVEQYVTPIMSRITGYVQEVRFNENQFVHKGDTLVVIDNREYKSKLNVALADVQNAQQNSVVAQKNAINTASATAINEAQLEAAKSNLWKTKLEYERYKALVSEEAATSQQLEKVKADYESAQAHFQEMKNRIHSSALSTSVAEANVPTTQTNIASKQAVADNAALFLSYTIITAPYDGWVGKRTLQPGQLVKEGQSLLSIVSKEKWITANFKETQLQYLTVGQDVEIKADALSDKTFVGTIASLSPASGARFSLLPPDNATGNFVKIEQRIPVRIQLKDSDKQADFLRAGMNITVIAAH
>NZ_CP043612.1|WP_111375848.1|1316455_1317811_-|TolC-family-protein
MFLKTTNSTDDCFPRILLLFLIVLAFNGLQAQEVHTVSLQEALKLAKENNKKILRSQLEVTLSEQNIKERKELRLPDVQLNGMYSRITNITEFKGSGFLKDKEVTPAIPEIYEVNSTFKMPIYAGNKINNAIKIANQESEIAKIKSEKTENDIELEVVANYLAIYKMMELQKIFEENIKEEKSRLKEVQSLQKHGTVTKNEVIRAELQLSDRELNALTNSKNIKIALHDLKTLIQIPENEEIAIDTTSSLDEMNGLDPYDFYMNKALQNEEMRIASQELNISKTELKMVKGNYLPSVHFFGNYGFYYPNYKFFPPNPYLYTLGQVGIEATFDLSSLYKNKTKMEQASTKIKWQEMQNEIVKEEIQDKLYKEHTQYQEILEKFVVVDKALDLADENYRIVKLKYLNQLVLITEMVDADNALLQAKYNKISTRLDAVLKHYELLHTAGMLPQS
>NZ_CP043612.1|WP_111375849.1|1318082_1318904_-|helix-turn-helix-transcriptional-regulator
MEHSGQKLDKYYIRKVDADKKSIYCHHDLMGELFIPPHRHVKAQLLYAEGDVVFVTTETKTYFLPARHFIWIPSGVEHSIEPKSESVTMRNLYFPVEKEEDDFYKVEGIYPVNNLLLQMMLFTNRWNGDLKKGTPNFAIAKAIKAILPQICTNNLPLELPQPKDKRLGKILRYIENNLGETILFADVAHEFGFSERSLYRLFQKDLGMSFIQYYTIRRILKAIELLLERKLSVKEVAEEVGYNSVPTFSNTFFKILGQRPSDYLNGEEILESK
>NZ_CP043612.1|WP_111375851.1|1320132_1321059_-|DUF58-domain-containing-protein
MKIESEIEKVSSFQHLEMLANQIVEGFISGMHKSPFHGFSAEFAEHKVYNAGESTKHIDWKLFAKTDRLYTKRFEEETNLRCHLIVDNSSSMHYPELKSNQPFYEKKIGFAVLASAVLMNILKKQRDAVGLSVFSDKYEYYAPEKGSDRHHRMLLNKLEELLVQPKVKKTTDTITYLHQIAEKMHRRSMIILFTDMFQTEDDEKLFNALQHLKHNKHKVVLFHVVDNETELKFDFDNTPRKFIDLESGEEVSIFADNVKEQYEKRVEAYFKNLALTCAKNQIKYVPVNVGDNFEKILTTYLVEKQNFG
>NZ_CP043612.1|WP_111375852.1|1321055_1323632_-|peptidase-M1
MKIFYSFLCFFMFISNIFSQSKEMQVYLLDKGVSESLANYRKQEISEVTYGLSFEIPNKKEEQIKAGLVLEVTLLNHPYRYIYLDFKEKTENIKAIEVNGKKVPIVHENGHIVIDSAALVSGKNTVSVSFIAGNLSLNRNDDFLYTLLVPDRASTLFPCFDQPNLKATYKLSLSVPKDWSVLAGANVVGKLEKGDFTSYTFGESDKMSTYLFSFVAGKFKSATQKPGLEMTMLYRENSPEKFRVSADTIFNLHQQSLDFLEKYTDRKFPFQKLDFASIPVFQYGGMEHVGAIQYRESTLFLDNSATDSEKLNRAKLIAHETSHMWFGDLVTMKWFDDVWMKEVFANFMADKIMNPIFPKVNHNLQFFTAHYPSAFAEDRSLGTHPIKQHLANLKDAGSLYGAIIYNKAPIMMRQLEASMGKEAFQKGIQKYIQKYANDNADWNNLVELLDAETPLDMKKWSDVWVNKSGRAIFTDQIEYDAKNRIKSFQIQQQAEDKSENIWPQVFQIGLVYAKEVKVLSVNINDKNTAVKEAVGLEKPLAIVYNYNGFGYGVFPLDGNNLNYIADLKDEMARASSYSNIYENTLIGNVSPEKALDCFLKGIQTEQNELVLRMAAGSLNTIYWRLLTEKQQSKVQKQLEGVLYERLQANLSSNIKKTLFGLFSSIAYSDSAKASLYKVWNREISIPNLKLNEDDYTNMAMNLAIFKHPKADEILEKTRASFTNPDKQKRFEFLLPSLSKDESVRNAFIESLKDDANREKESWVSVGLANVNHPLRQESAQKYIRFSLDLVDEIQRTGDIFFPKDWLDNTVGKYSSKYAFDEVQRFLKENPNFSPILKRKLFQATDLLYKAQNIKKETE
>NZ_CP043612.1|WP_111375853.1|1323789_1324140_+|hypothetical-protein
MKKKLKFINLLMPLIVLFAILFPAIHSYEHILDTHSSKEKLEFSVSEKPQFKAKLHSFHKCSICDFKFSAVGTFEINIFQFFKNNPAVKHINFYSKPHFTFFKGALFSLRAPPFTL
>NZ_CP043612.1|WP_162615449.1|1324588_1325020_+|DUF4625-domain-containing-protein
MKTTKLILVSLFAAMAFTSCSNDDSEEKQAIPTIDKIELGLSNSETATIGADFHFNAEVTAADKIENVQVKIVQKNTETYSEVWSHEITWTQYAGAKNATVHKHFDIPEDAVAGKYDFIIIVNDQNGSKLEVKKNLTIINQKI

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Crispr_ID: NZ_CP043612_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_5

1350480-1350588

Orphan

Consensus_repeat	Method
ACATTTTCTAATTGACACATTAATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_5

>merge|NZ_CP043612|5|1350480-1350588|CRISPRCasFinder
ACATTTTCTAATTAAAAACATTTTCTAATTGACACATTAATAATTAGATAATTCAGATAATGAGATAAATTAGATAATTTTAAAGGATTCTCTAATTGACACATTTTCT

>NZ_CP043612|5|5|1350480-1350588|CRISPRCasFinder
ACATTTTCTAATTAAAAACATTTTC	TAATTGACACATTAATAATTAGATAATTCAGATAATGAGATAAATTAGATAATTTTAAA
GGATTCTCTAATTGACACATTTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111376065.1\|1357632_1358031_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224397
NZ_CP043612.1\|WP_008466263.1\|1350606_1350846_+\|NifU-family-protein	unknown	unknown	gnl\|CDD\|376458
NZ_CP043612.1\|WP_111376034.1\|1344736_1347166_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274576
NZ_CP043612.1\|WP_111376040.1\|1353784_1354162_-\|large-conductance-mechanosensitive-channel-protein-MscL	unknown	unknown	gnl\|CDD\|376605
NZ_CP043612.1\|WP_111376032.1\|1342508_1343753_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP043612.1\|WP_111376066.1\|1358025_1358730_-\|PorT-family-protein	unknown	unknown	gnl\|CDD\|372635
NZ_CP043612.1\|WP_142479076.1\|1340998_1342348_-\|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
NZ_CP043612.1\|WP_111376035.1\|1347232_1348834_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|225536
NZ_CP043612.1\|WP_167511655.1\|1358954_1359308_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111375865.1\|1339315_1340641_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP043612.1\|WP_111376041.1\|1354230_1356702_-\|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase	unknown	unknown	gnl\|CDD\|237026
NZ_CP043612.1\|WP_111286436.1\|1338813_1339140_+\|MGMT-family-protein	unknown	unknown	gnl\|CDD\|376440
NZ_CP043612.1\|WP_111376033.1\|1343895_1344603_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP043612.1\|WP_111375864.1\|1338091_1338730_+\|lysine-transporter-LysE	unknown	unknown	gnl\|CDD\|224199
NZ_CP043612.1\|WP_111376037.1\|1351060_1351540_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111376038.1\|1351989_1352499_-\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|214864
NZ_CP043612.1\|WP_091490641.1\|1351599_1351917_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|178203
NZ_CP043612.1\|WP_111376039.1\|1352618_1353608_-\|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
NZ_CP043612.1\|WP_073408106.1\|1337372_1338050_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP043612.1\|WP_111376036.1\|1349252_1350380_+\|Mrp/NBP35-family-ATP-binding-protein	unknown	unknown	gnl\|CDD\|378455

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111376065.1\|1357632_1358031_+\|hypothetical-protein	gnl\|CDD\|224397	COG1480, COG1480, Predicted membrane-associated HD superfamily hydrolase [General function prediction only].	0.000795732
NZ_CP043612.1\|WP_008466263.1\|1350606_1350846_+\|NifU-family-protein	gnl\|CDD\|376458	pfam01106, NifU, NifU-like domain. This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.	2.28521e-24
NZ_CP043612.1\|WP_111376034.1\|1344736_1347166_+\|ABC-transporter-permease	gnl\|CDD\|274576	TIGR03434, ADOP, Acidobacterial duplicated orphan permease. Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.	2.64099e-34
NZ_CP043612.1\|WP_111376040.1\|1353784_1354162_-\|large-conductance-mechanosensitive-channel-protein-MscL	gnl\|CDD\|376605	pfam01741, MscL, Large-conductance mechanosensitive channel, MscL.	5.47119e-52
NZ_CP043612.1\|WP_111376032.1\|1342508_1343753_+\|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	2.80356e-22
NZ_CP043612.1\|WP_111376066.1\|1358025_1358730_-\|PorT-family-protein	gnl\|CDD\|372635	pfam13568, OMP_b-brl_2, Outer membrane protein beta-barrel domain. This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	3.45045e-11
NZ_CP043612.1\|WP_142479076.1\|1340998_1342348_-\|sigma-54-interacting-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.3168e-154
NZ_CP043612.1\|WP_111376035.1\|1347232_1348834_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|225536	COG2989, COG2989, Uncharacterized protein conserved in bacteria [Function unknown].	3.32797e-80
NZ_CP043612.1\|WP_111375865.1\|1339315_1340641_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.93681e-31
NZ_CP043612.1\|WP_111376041.1\|1354230_1356702_-\|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase	gnl\|CDD\|237026	PRK11930, PRK11930, putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional.	0
NZ_CP043612.1\|WP_111286436.1\|1338813_1339140_+\|MGMT-family-protein	gnl\|CDD\|376440	pfam01035, DNA_binding_1, 6-O-methylguanine DNA methyltransferase, DNA binding domain. This domain is a 3 helical bundle.	1.51949e-34
NZ_CP043612.1\|WP_111376033.1\|1343895_1344603_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.71782e-110
NZ_CP043612.1\|WP_111375864.1\|1338091_1338730_+\|lysine-transporter-LysE	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	0.000110321
NZ_CP043612.1\|WP_111376038.1\|1351989_1352499_-\|SMI1/KNR4-family-protein	gnl\|CDD\|214864	smart00860, SMI1_KNR4, SMI1 / KNR4 family. Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.	2.03476e-06
NZ_CP043612.1\|WP_091490641.1\|1351599_1351917_+\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|178203	PLN02593, PLN02593, adrenodoxin-like ferredoxin protein.	5.27708e-15
NZ_CP043612.1\|WP_111376039.1\|1352618_1353608_-\|aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	2.6859e-172
NZ_CP043612.1\|WP_073408106.1\|1337372_1338050_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	4.76292e-66
NZ_CP043612.1\|WP_111376036.1\|1349252_1350380_+\|Mrp/NBP35-family-ATP-binding-protein	gnl\|CDD\|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	1.91433e-131

>NZ_CP043612.1|WP_111376036.1|1349252_1350380_+|Mrp/NBP35-family-ATP-binding-protein
MKLDRKEILKALETITIAGEGKNMVESGAVTNVITFGDEAVVDLVLHTPAMHIKKRAEDDIKKTIHDLISPDAKVKVNIKVEAPEKPEIKGRAIPGIKNIIAVASGKGGVGKSTVTANLAVTLAKMGFKVGVLDADIYGPSMPIMFDVENAKPVSVTVDGKSKMKPIESYEIKMLSIGFFTAPSQAVIWRGPMAAKALNQMIFDADWGELDFMLLDLPPGTGDIHLSIMQSLPITGAVVVSTPQAVALADAKKGVAMFMQDNINVPVLGIIENMAYFTPEELPENKYYIFGQEGAKNLAEDLGVPFLGEVPIVQSIREAGDYGRPAALQTASPIEKVFEEITRNVVQETVNRNESLPATEAIKITTMAGCSAVKK
>NZ_CP043612.1|WP_111376035.1|1347232_1348834_-|L,D-transpeptidase-family-protein
MRNFTFSLIIVTVGFFAFSFNSFSNNAKSKADLTNRKSVAVITLDATSINAFFKKYPKLKKYQKDVEDIYKAKQYKSIWYDDKSITEFGSLLYQKVNVLKDQGIEEKMPYKEQIDEAFNESSSNKPSQLDTELLLTSMYVFYASNVYSGVDPATLKKIGWYLPAKSISYTHILDSLMVDSDRLDKDDNLLFSQYYRLKDALKKYRKIETDNLWQKITIDSATFKDLRPDDTAIAIKQIRQRLFAVGDLKKDSGSDIYDEELMAGVLNYKKRYNLKINYALTRDIINQMNEPIGKRIRTIMLNMERCRWIPTKLSKADEYVMVNIPSFRLFYVKDGKYDLVSDIFVGNRLSETVIFSGNMDRIVFSPYWYVPTSIIQNELKLQIANDKNYLEEHNMEWNGGKVRQKPGPKNSLGLVKFMFPNPNDIYMHDTPAKSLFEFEKRTFSHGCINVKEAKQLALHILKDDPDWPADKIESAMNGGKETTCMLKRKIPVYIGYFTCWVQDNGEVNFFPDVYDRDQSLDKLIYNDAVTMKD
>NZ_CP043612.1|WP_111376034.1|1344736_1347166_+|ABC-transporter-permease
MIFNWFKIFIYHLKQSKLFSFLNVLGLSIGIAGVIFAILYWNNEHSYDQWNPEKENTYMVLNRLSNGDTWGSNSIPFGETCKASIPEIENVCFFHTWYDEDIIKYQDQKLMTKDILSSDENFFDFFPFEIIKGAKSNILKEKNSVAISEEQALLIFKNEDPIGKSISYGNKNYTIKSVYRISKPSSIEPSFVFSDVKREGDLDAWGNFNYGLLIKTKKNADVSTVLKKMQNVYFVNRTVKDAKESGMTVEQYVKENGEIKVILDQLKTSRLYGTKSSAGQNYPEGVGNLKLLYIMAGLSVLILVLSLVNYINLATASAIKRAKEVGVRKIVGASKNQIIIQFIFETAIIVTLAILFALAIVELSLPYYNTFLNKTLTMNGSEFYLQLIFIFGLVIVLAGIFPAIYISNFETLKVLKGNFSRSKSGIWIRNSMLIFQFGIAAFFIIGALIVNSQVKYMMEKDLGFSGDQVISIPFNTVDRLKRTDDYLVSKQEIKKIPGVVDVTTFAGAFGGNSGSSSGFKHNGIFVQPKNIEMDFGFLDMMKIKIVKGRDLSPQYASDTISGMLMNETLVKMLNLKDPINTVITSGWSINNGDNLKFKIVGVVKDFNLMGLQNKVPPMVFINLKTLKWNNFGSVLVKVSPNNLTETLDKLKLYWEKNVNPDYPFDYEFVNKGFAKTYEEQVKQKNLFFILNLVVIIIAVFGLFALASFSMERRLKEIAIRKTLGAETDILLKELSKQYIVFCLIGFAIGIVPAYILLQKWLEDFAFRIGISSVPFVIALISLLILTLVIVLTKAFQVTKIDVLKYLKYE
>NZ_CP043612.1|WP_111376033.1|1343895_1344603_+|ABC-transporter-ATP-binding-protein
MITIQNLTKVFRTEEIETAALSGINVEIKKGDFLTIMGPSGCGKSTLLNIIGLLDSADGGSYKLLDQEMIGLKEKGRAQVRKENIGFIFQNFNLIDELSVYDNIELPLLYNNVKASERKQKIEAIAEKLNISHRLKHFPQQLSGGQQQRVAVARALVNDPKIILADEPTGNLDSKNGNEVMELLTDLHAKGATILMVTHSDYDASFSQRTIHMKDGVIFSEKLNQRNVDVFMDAK
>NZ_CP043612.1|WP_111376032.1|1342508_1343753_+|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MDTVIPRKNKKFRYLAIAIAVFLVLLTISVFAFNTKRTLNVKADELVIQKAEKAFFEDFVVFQAKVEPLNVMLVNVTEGGSVKEIFVENGAMVTKGQSLARLYNPNTELNYLTQETAIIEQINNLNTGKLNIRNQELNLNKDLVLIEHDYNDAKRLYDMNAKLYEKDVISKNDWNTFKESLRFQEERKRTIQQSIQKEKQSNQVQISQINRSIQTMEKSLDILRNNKKNFLITAPETGRLTSFEPVLGKTFQAGASIGKIDSNKGYKLTAEVDEFYLEKLREGLKGQVEFKGKNLEVIVTKVIPEVKGGRFTVELAFASKENIVLQDGLSFGVKLILSEKNKTLVIPRGAFNQEAAGKWIFVVNGNKAVRRNIKLGRENPSYYEVLEGLKEGESVVTSSYTDYKDIEELSLNKE
>NZ_CP043612.1|WP_142479076.1|1340998_1342348_-|sigma-54-interacting-transcriptional-regulator
MRKKLAQILVVDDQEEILFSAKMILKKHFETIFTTNSPKKIISILSENEINVVLLDMNYRIGFEDGREGIHWLKEIKTLSPRTVVILMTAFGKIETAVEGIKIGAFDYVLKPWNNEKLIEVIDKAVAESRKNSKKTAEKVEKTEKKYFVGTSAKIKQAYSMAEKVARTDANVLILGENGTGKYVFAEFIHQHSERKNEPFVHVDLGSLSDNLFESELFGYAKGAFTDAKIDTPGRFENASNGTIFLDEIGNIPLHLQAKLLHVLQTKTVTRLGESKPRPLNVRVIAATNSDIKTEVKNKTFREDLLYRINTMEINLPSLRERKDDIVPMANFILEQIAEKYNQENWRFEDNAGSYLEKYPWKGNVREMENKIERALILAENNTISVMDLDILDFEEIQENDENPLSEMEKGAIEKALFKHNGNISKTAEELGLSRAALYRRIEKYDLKN
>NZ_CP043612.1|WP_111375865.1|1339315_1340641_-|HAMP-domain-containing-histidine-kinase
MKNWKFYNALFVRVLFVMVLFLATALLFYKGFHYNALLVGVFVLIFLFEMYFFVKNQLLFYDKTINSILHDDFSAHFPEEHKKDNFNSLYHLYDTLKVQKQEQISKELIYRSILNSIDTAALILEKENEDWSIFIMNDCFSNLFKVPKVSHWQYLKNYLPSLCSEIEKVGFTELKKAISIKIEDQDLQTFMLQTSHTQTYNKEYFIILLDSIQRVIEKKEKEAWINLMKIISHELMNSLTPIRALSQNLLHIVDQEELEEDDFEDIKSSISTIINRSDHLQFFVENYRKLAMLPTPNKQMTPINVLFEDCLRIMSPILKEEKIELINEIHSSRSIMIDKNQMEQVIINLITNSIHALMEKTEKKLLISSYTENNRFFIVISDNGKGVDAEIRDKVFLPFFTTRKDGAGIGLTLSKNIIEAHGGYLSYQTDEDKTSFVICLI
>NZ_CP043612.1|WP_111286436.1|1338813_1339140_+|MGMT-family-protein
MAEENFFERVYVIARQIPFGKVTSYGAIAKALGTARSARMVGWAMNACHNMDDVPAHRVVNQKGLLTGKHHFDGTNLMQQLLENEGIKVVNNQIVDFEKHFWKPEVES
>NZ_CP043612.1|WP_111375864.1|1338091_1338730_+|lysine-transporter-LysE
MTYLTPLISGFIAAAIGTIPPGLLNMTAAKIKMKEGKKNALSFVIGAVLIIFFQAYIAVLFARVIDNRPDVVILLREAGFIIFSILTIYFFFFAKDPIAKKKTKLKKTSKKSSFFLGMLLSGLNFFPIPYYVVISVTLASYHLFVFENTIILTFVLGSVLGAFAILYSYIAFFGRIEKKTDYFMRNMNTIIGTITGLVALATLFNILNYYFG
>NZ_CP043612.1|WP_073408106.1|1337372_1338050_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MGSKNKLKRFRENETFQNVFQPTREEVVGDLMPLKGKWNSDFFKNDNPLVLELGCGKGEYSVGLAEKYPNKNFIGIDIKGARFWRGAKTAVENGLHNVAFVRTQIELINHIFAEGEVDEIWITFPDPQIKYKRTKHRMTNSEFLKLYKKILKKDGVVNLKTDSEFMHGYTLGLLHGEGHEVLYANHNVYKNEGSPEVVTSIQTFYEKQYLEINKAITYIRFKIKD
>NZ_CP043612.1|WP_008466263.1|1350606_1350846_+|NifU-family-protein
MTTEEITSNVLLALDEIRPFLKSDGGDISLISIEDDKHVKVRLEGACISCSVNQMTLKAGVETTIKKYAPQIETVVNVM
>NZ_CP043612.1|WP_111376037.1|1351060_1351540_+|hypothetical-protein
MRNFYALFLLFFLSAVNAQQGQTLFAEKAWVNESEEWSDFQYSGQIIFSTNGKTEEGALRIGNYDFLYDLCDGKAKFSNRATYSSADFSHPRKISAQTDKQGVLNSTYEGTLIFQADKDYYSVISLVTILEKGGNIIGVKMRLKDGNRKEYAFSLKEKS
>NZ_CP043612.1|WP_091490641.1|1351599_1351917_+|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MDVLIKIKDREGVIHELQAPTDMAMNIMELCKAYELPVEGTCGGMAMCASCQCYVLNDVALPEMGDDEEAMLSEAFYVKSNSRLGCQIPITEDLEGLELELAPEY
>NZ_CP043612.1|WP_111376038.1|1351989_1352499_-|SMI1/KNR4-family-protein
MNFDKYKIIPNYNTNKTDLFTADEEDILACEKTLNITFDEDYKEYVQTYGSGILGGTYVRVYLPETIVLTLEEWKNRITEYWFWDEGKEVLTKEEVLNSIRVGDTFDGDEIILLNNQYYILPRYSEMIYKAGNTLEETITWLCSAGILTEAFSEREFEPFDPSVFLNSN
>NZ_CP043612.1|WP_111376039.1|1352618_1353608_-|aspartate-semialdehyde-dehydrogenase
MRIAVVGATGMVGEVMLKVLAERNFPVTELIPVASERSVGKEIEYKGTKYKVVGLQTAVDMKADIAVFSAGGDTSLEWAPKFAAAGTTVIDNSSAWRMDPTKKLVVPEINANVLTKEDKIIANPNCSTIQMVMTLAPLHKKYNIKRIIVSTYQSITGTGVKAVKQLENEYAGVQGEMAYKYPIHRNAIPHCDSFEENGYTKEEMKLVRETQKILGDNTIRVTATAVRVPVVGGHSEAVNVEFTNDFDVNEVREILHHTDGVTVQDNLDTFTYPMPLYAEGKNDVFVGRIRRDESQPNTLNMWIVADNLRKGAATNTIQIAEYLIKAGLV
>NZ_CP043612.1|WP_111376040.1|1353784_1354162_-|large-conductance-mechanosensitive-channel-protein-MscL
MGFFSEFKEFAMKGNVVDLAVGVIIGAAFGKIVSSFIEDVITPLLLKPALDAAHLSTIEQLTAFGGVKYGVFISAVINFIIVAFVLFLIIKGMNHAKKKDVAPPPPAGPTQEELLTQIRDLLKNK
>NZ_CP043612.1|WP_111376041.1|1354230_1356702_-|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase
MSLNLKSLVSVLNAKWIGTNADVLIDHISIDSRSLQNGSQTLFFALAGVNNDAHLFIPDLIENGVQNFVVQYIPDGYIDKANFLVVENTLQALQEFAAYYRNIFHFPVIGLTGSNGKTIVKEWLNFLLSPDYNIIRSPKSYNSQVGVPLSVIGINEKHNLGIFEAGISTVNEMIKLEKIIKPTIGVLTNIGSAHDEGFLNLVQKIDEKLLLFKDCPIIIYQKTEVVESCLTQFAAEYMIHPRKLFSWSFTDKKADVFIEKREYKNDHTFIEYHYKNEIFNLEIPFNDSASIENAISCLLVLLHFNYDQETIQNRIQMLYPVRMRLEVKNGINNCSIIDDSYSSDFQSLKIALDFLESQKKKGASKTVILSDIFQSGFTNEELYSKVAQLISDNKINRIIGIGPTISSFAAKFLNSTMFENTANFIAAIDNFNFHNETILIKGARSFEFEEIVSLLEEKTHETILEINLDAISHNFNYYKSKLAPGVKMMVMVKAFGYGNGGLEIAKLLEHHKVDYLGVAFADEGISLKNGGIKVPIMVLNPESTSFPSMIQYQLEPEIYSLKGLNAFLKIAREKNLKDYPIHIKMDTGMHRLGFENNTIDELIATLKGNSTVRVQSILSHLATSDDPKHFDFVRQQIALFEKLSSRLMTELNINPIRHTLNTSGISNFPDAQYSMVRLGIGLYGVSNDPAEQKYLENVGTLKSIISQIRTIPGGDSVGYGRRFMADAATKIATIPIGYADGISRLWGNEVGYVTIKNQKAKIVGSVCMDMLMVNVSDIECKEGDSVIIFGESPTVIEMAVALKTIPYEIMTSISQRVKRVFFR
>NZ_CP043612.1|WP_111376065.1|1357632_1358031_+|hypothetical-protein
MLGQTSERTIPLILQCFLYILLVKRSIVITRYPELHFFFLSALFSTILALVCVLFKTKASLHMVAISGLTIFVIGLNIHLQLHNPYWPALLILLSGIVASSRLEMNAHTSREILIGLFIGIMPQLLFLYLWL
>NZ_CP043612.1|WP_111376066.1|1358025_1358730_-|PorT-family-protein
MRIIFSCLLLLTFFNSFAQEDVKSEVKPVVKIDSLYREDQFYFSVTYNMFTDIPIDFKQNKFSLGLSGGFLRDMPINKSRTVAIAAGLGLSYQNYYQNLTISEDGSGKTIYGVNDYGQFVSNRYRQYSVDLPIEFRWRNSTYESTKFWRIYGGVKLSYIFSSASTLDDGETKYKIKNNADINKFQYGPYLAAGYNTWNVYIYYGLSPLFKSATTLNGEKINMKTLNAGLIFYIL
>NZ_CP043612.1|WP_167511655.1|1358954_1359308_+|hypothetical-protein
MKRKQLILSLSFAVTILFSILFQSIHSYEHIVKQLSEKQCHHNYNDPSGEITHQHHDYDVCFVCHFAFESFILPQNFSFEFHSFDRETPYFLPFSEKIFSVSNTSYFLRGPPVAIVS

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Crispr_ID: NZ_CP043612_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_6

1659596-1659714

Orphan

Consensus_repeat	Method
AAGGGATTGATTCAGCTGTATTGTAACCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_6

>merge|NZ_CP043612|6|1659596-1659714|CRISPRCasFinder
AAGGGATTGATTCAGCTGTATTGTAACCCTAATAAAAACAGAGCACTGGGACTGATAAAGCTTGTTTGTTCCCATAAAAGACAAAGCACAAGGGATTGATTCTGCTGTATTGTAACCCT

>NZ_CP043612|6|6|1659596-1659714|CRISPRCasFinder
AAGGGATTGATTCAGCTGTATTGTAACCCT	AATAAAAACAGAGCACTGGGACTGATAAAGCTTGTTTGTTCCCATAAAAGACAAAGCAC
AAGGGATTGATTCTGCTGTATTGTAACCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111378772.1\|1655732_1656749_-\|nucleotidyltransferase	unknown	unknown	gnl\|CDD\|133024
NZ_CP043612.1\|WP_111378767.1\|1662499_1663033_-\|ATP-synthase-F1-subunit-delta	unknown	unknown	gnl\|CDD\|365949
NZ_CP043612.1\|WP_111378774.1\|1653545_1654325_-\|DUF4292-domain-containing-protein	unknown	unknown	gnl\|CDD\|372917
NZ_CP043612.1\|WP_095930604.1\|1663037_1663538_-\|F0F1-ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|184695
NZ_CP043612.1\|WP_111378764.1\|1665604_1665832_-\|AtpZ/AtpI-family-protein	unknown	unknown	gnl\|CDD\|378198
NZ_CP043612.1\|WP_111378768.1\|1660884_1662462_-\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|236448
NZ_CP043612.1\|WP_111378769.1\|1659934_1660795_-\|ATP-synthase-F1-subunit-gamma	unknown	unknown	gnl\|CDD\|376304
NZ_CP043612.1\|WP_111378765.1\|1665154_1665547_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378777.1\|1647612_1650603_+\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|274948
NZ_CP043612.1\|WP_111378766.1\|1663860_1665036_-\|F0F1-ATP-synthase-subunit-A	unknown	unknown	gnl\|CDD\|237381
NZ_CP043612.1\|WP_008465845.1\|1656813_1657248_-\|dUTP-diphosphatase	unknown	unknown	gnl\|CDD\|234802
NZ_CP043612.1\|WP_111378773.1\|1654332_1655685_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP043612.1\|WP_111378778.1\|1646833_1647253_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341361
NZ_CP043612.1\|WP_008465835.1\|1663628_1663826_-\|ATP-synthase-F0-subunit-C	unknown	unknown	gnl\|CDD\|349414
NZ_CP043612.1\|WP_111378771.1\|1657275_1658733_-\|oligosaccharide-flippase-family-protein	unknown	unknown	gnl\|CDD\|240533
NZ_CP043612.1\|WP_111378775.1\|1652267_1653521_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|227278
NZ_CP043612.1\|WP_111368379.1\|1665812_1666211_-\|polymer-forming-cytoskeletal-protein	unknown	unknown	gnl\|CDD\|377376
NZ_CP043612.1\|WP_111378770.1\|1658828_1659275_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP043612.1\|WP_111378776.1\|1650620_1652201_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|185760
NZ_CP043612.1\|WP_111378763.1\|1666223_1668836_-\|gliding-motility-protein	unknown	unknown	gnl\|CDD\|276809

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111378772.1\|1655732_1656749_-\|nucleotidyltransferase	gnl\|CDD\|133024	cd04181, NTP_transferase, NTP_transferases catalyze the transfer of nucleotides onto phosphosugars. Nucleotidyltransferases transfer nucleotides onto phosphosugars. The enzyme family includes Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase. The products are activated sugars that are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides.	2.39983e-55
NZ_CP043612.1\|WP_111378767.1\|1662499_1663033_-\|ATP-synthase-F1-subunit-delta	gnl\|CDD\|365949	pfam00213, OSCP, ATP synthase delta (OSCP) subunit. The ATP D subunit from E. coli is the same as the OSCP subunit which is this family. The ATP D subunit from metazoa are found in family pfam00401.	2.12953e-49
NZ_CP043612.1\|WP_111378774.1\|1653545_1654325_-\|DUF4292-domain-containing-protein	gnl\|CDD\|372917	pfam14125, DUF4292, Domain of unknown function (DUF4292). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.	3.96642e-67
NZ_CP043612.1\|WP_095930604.1\|1663037_1663538_-\|F0F1-ATP-synthase-subunit-B	gnl\|CDD\|184695	PRK14471, PRK14471, F0F1 ATP synthase subunit B; Provisional.	4.99707e-74
NZ_CP043612.1\|WP_111378764.1\|1665604_1665832_-\|AtpZ/AtpI-family-protein	gnl\|CDD\|378198	pfam09527, ATPase_gene1, Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter. This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme. It carries two transmembrane helices and is a magnesium or calcium uniporter. The atp operon of alkaliphilic Bacillus pseudofirmus OF4, as in most prokaryotes, contains the eight structural genes for the F-ATPase (ATP synthase), which are preceded by an atpI gene that encodes a membrane protein with 2 TMSs. A tenth gene, atpZ, has been found in this operon, which is upstream of and overlapping with atpI.	1.65076e-11
NZ_CP043612.1\|WP_111378768.1\|1660884_1662462_-\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|236448	PRK09281, PRK09281, F0F1 ATP synthase subunit alpha; Validated.	0
NZ_CP043612.1\|WP_111378769.1\|1659934_1660795_-\|ATP-synthase-F1-subunit-gamma	gnl\|CDD\|376304	pfam00231, ATP-synt, ATP synthase.	2.62205e-129
NZ_CP043612.1\|WP_111378777.1\|1647612_1650603_+\|TonB-dependent-receptor	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043612.1\|WP_111378766.1\|1663860_1665036_-\|F0F1-ATP-synthase-subunit-A	gnl\|CDD\|237381	PRK13419, PRK13419, F0F1 ATP synthase subunit A; Provisional.	1.57993e-73
NZ_CP043612.1\|WP_008465845.1\|1656813_1657248_-\|dUTP-diphosphatase	gnl\|CDD\|234802	PRK00601, dut, dUTP diphosphatase.	6.41387e-85
NZ_CP043612.1\|WP_111378773.1\|1654332_1655685_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.06158e-11
NZ_CP043612.1\|WP_111378778.1\|1646833_1647253_+\|CBS-domain-containing-protein	gnl\|CDD\|341361	cd04584, CBS_pair_AcuB_like, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the ACT domain. The putative Acetoin Utilization Protein (Acub) from Vibrio Cholerae contains a CBS pair domain. The acetoin utilization protein plays a role in growth and sporulation on acetoin or butanediol for use as a carbon source. Acetoin is an important physiological metabolite excreted by many microorganisms. It is used as an external energy store by a number of fermentive bacteria. Acetoin is produced by the decarboxylation of alpha-acetolactate. Once superior carbon sources are exhausted, and the culture enters stationary phase, acetoin can be utilised in order to maintain the culture density. The conversion of acetoin into acetyl-CoA or 2,3-butanediol is catalysed by the acetoin dehydrogenase complex and acetoin reductase/2,3-butanediol dehydrogenase, respectively. Acetoin utilization proteins, acetylpolyamine amidohydrolases, and histone deacetylases are members of an ancient protein superfamily.This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce acetoin as an external carbon storage compound and then later reuse it as a carbon and energy source during their stationary phase and sporulation. In addition these CBS domains are associated with a downstream ACT (aspartate kinase/chorismate mutase/TyrA) domain, which is linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.59557e-35
NZ_CP043612.1\|WP_008465835.1\|1663628_1663826_-\|ATP-synthase-F0-subunit-C	gnl\|CDD\|349414	cd18121, ATP-synt_Fo_c, membrane-bound Fo complex of F-ATP synthase, subunit c. Subunit c (also called subunit 9, or proteolipid) of the Fo complex of F-ATP synthase. The F-ATP synthase (also called FoF1-ATPase) consists of two structural domains: the F1 (factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha, beta, gamma, delta, and epsilon subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons though the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts, or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Methanosarcina acetivorans.	2.58508e-09
NZ_CP043612.1\|WP_111378771.1\|1657275_1658733_-\|oligosaccharide-flippase-family-protein	gnl\|CDD\|240533	cd13128, MATE_Wzx_like, Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.46475e-32
NZ_CP043612.1\|WP_111378775.1\|1652267_1653521_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|227278	COG4942, COG4942, Membrane-bound metallopeptidase [Cell division and chromosome partitioning].	9.63492e-25
NZ_CP043612.1\|WP_111368379.1\|1665812_1666211_-\|polymer-forming-cytoskeletal-protein	gnl\|CDD\|377376	pfam04519, Bactofilin, Polymer-forming cytoskeletal. This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localization and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	1.82708e-25
NZ_CP043612.1\|WP_111378770.1\|1658828_1659275_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.18515e-14
NZ_CP043612.1\|WP_111378776.1\|1650620_1652201_+\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	5.53753e-28
NZ_CP043612.1\|WP_111378763.1\|1666223_1668836_-\|gliding-motility-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.00195246

>NZ_CP043612.1|WP_111378770.1|1658828_1659275_-|GNAT-family-N-acetyltransferase
MALQIKELTTIDDMVAQISTIRFLYPNISLEKYKSFLSEMLPHNYIQIAVFEDDICLGLTGCWSATKLWTGKYLEIDNFVVNPEYRSKGIGKMLTDYIDKKATELNCSSIVLDAFTGNFGAHRFYYNQGYAPRGFHFVKILDEKKLTV
>NZ_CP043612.1|WP_111378771.1|1657275_1658733_-|oligosaccharide-flippase-family-protein
MGLYKNLFKQTAIYGLATVLPRMLSFLLVRLYTGILPTAEYGEVSIVLSWMVFFNVVLSYGMETAFFRFYSAEEDKKNVIATSTISIFWTSIIFLFAGLIFRNTLANLAEVDVQYITYTIWILVLDALVLIPFSKLRANQRPMVYAAIKIGNVVINLLLNIFFLMYLPKLAEANPNSVWDNLYVQNFQIAYIFIANLLASLATFIVLSPNYLSLGRKFDPVLWKKMMKYGLPILVAGLAFAVNEHFDKILLGYLLPENLAKSEVGAYSACYKLGLFMVLFATAFRLGIEPFFFSHAKNENAPQTYAVITKYFVILGSLILLGVIVFADVLKYLLLDNKSYWEAMKVVPLIILANFFLGIYNNLSVWYKLTDKTKIGAYISIVGAIVTLILNYLLIPKYSYYGSAIATISAYGSMMLISYVLGNKYYPIPYDMNKIGAYLGVSIVFSIISFYGFREKYYVGIPLLLIFIYMVYHFEKDTIKGIMKK
>NZ_CP043612.1|WP_008465845.1|1656813_1657248_-|dUTP-diphosphatase
MKIQIINKSQHDLPNYETIASAGMDLRANIIEPITLKPLERTIVKTGLFIELPIGYEAQVRPRSGLAAKKGVTVLNSPGTVDADYRGEIGVILVNLSNDDFVIENGERIAQLIIAKHERAEWIEVETLSETSRGEGGFGSTGVK
>NZ_CP043612.1|WP_111378772.1|1655732_1656749_-|nucleotidyltransferase
MKIIVPMAGRGSRLRPHTLTVPKPLIPVAGKSIVHRLVEDIAKILKEPIEEVAFILGDEAFFGDDVVASLEDLAKGLGAKASIYRQDQPLGTGHAIMCAKDSLSGPAVIAYADTLIRADFELDPEADAVIWVKQVEQPEAFGVVKLNQNNEIIELVEKPKEFVSDLAVIGIYYFKEVGILKNELQNVLDNNIQNGGEYQINDGIKAMMANGKVFKTGSVDEWMDCGNKDVTVETNTRMLGFLHNDGEHLVDYGVTLENSTIIPPCYIGQNVVLKNTTIGPNVSLGNGCHVTDSTIKNSLIQTYSQIKNAALDNAMIGNHVSYDGKFTSISIGDYAVLE
>NZ_CP043612.1|WP_111378773.1|1654332_1655685_-|tetratricopeptide-repeat-protein
MIKKGVFTILVFALFSTSFSVFAQTEPEDIAMATDEYQDAFYESLKQKGIENYDKAIVSLEKCIKLKPNDAVAYFELGKNYFALKEYQNAQTAFEKATQLDPKNKWFWLGIYDVSYETKNYPLAIDIIQKIIVFDEEYKDDLISLYMITNQYDKALTAINEMNDKFGKSSDREIYKAQILSQGKYQNAEIDNLVQQIKKDPKEESNYLNLILLYSKNNENEKSLEVAKQLAKEIPNSEWGQVSLFKTYLDANQADKAIKSMNVILASSKIDSKIKHRTLNEFLIYVNKNPQYSADLEKAISYFDNDKDVDVAKEIGKFYHSKGQFENAIKYYEKDLKSNSDTDLETNMLLLEAYAQAKQYEPMTKRAMMLIEVYPSQAQFYYYAGLGSNQQKQFKNAKTVLEMGLDYVVDDVKLESNFNIQLGEAYNGLGDAKKKEEYFLKANEVLKKKK
>NZ_CP043612.1|WP_111378774.1|1653545_1654325_-|DUF4292-domain-containing-protein
MKKYISILVLSIAVISCKSKAVAVQGNTGQTIVEKEDKKIIEKHYNNKLDFSTLYIKASARYADEKQSQNVTAEIRIEKDKQILISVRFLGITMAKALITPSAVSYYEKMNGTYYEGDFTSLSKWLGTDLDYSKVQNLLVGEAFDDLRKGKYTQTIVDNLFRLDEEKDANLKKTFFLDGEKYLIQKEEISQPSENRTLQIAYSDTKTFDQGILPTSIEINAVQPKGKTSINLNYNNISFNEELSFPYSVPSGYKKVTIK
>NZ_CP043612.1|WP_111378775.1|1652267_1653521_-|peptidoglycan-DD-metalloendopeptidase-family-protein
MPKFLLSLVLVCATTFVWAQDSQQEKLEQRKAQIQQEIRDNEKMLQSVRKKEKSAVNEYLIQANKIKLKEKLINTTAKQERLIGNDMYINQVQVNKLKKELKVLKEDYAEMILKSYKSRSEQSRAMFILSSESFLQAYKRAQYLKQYTAFRKNQGLEIQSKTAQLVDFNAKLDGQRQVKKKIIAENQKEKVTLEAEKKEQQKLVNSLKKDKNKIAADIRSKQSEAKRIDRQIDRLIREAIAEANRKAAAERAKANPGSSEAKAPVSSSKIALTPEDKILAADFKANRGRLPWPVEKGFISLGYGDQPHPLHPSITVHNSGVEITTEDGASARAVFAGEVSKVIVLSPVNKAVVIQHGDFFTVYQNLSSVSVSQGDKVTIKQNIGKVRTSGDTGKTIIKFLILQNTSNNNPEGWLQSR
>NZ_CP043612.1|WP_111378776.1|1650620_1652201_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKILQYIFSGCALLFFSQCTDLAEEPYTFLSPSNYYKNADELNTALIGVYDGYQNGFNGNYKYIMYLEVLTEFGSPAYAKDDAQLWNVWSDMNNADKMVITNWDDAYNIINRANLVIGRGADVEMDEAVKKRYFAEARFLRAATYYNLVRMYGGVPIPETFTEGLKNLAIPRKTTEETYAYIIADLEYAEENLPQKSGYQSDNIWRASKGAAQALLGDLYLTRGSMTGDKTFFQKSKEYTTKVIQSGQYDLQSNFKDLWYWWNINNKNGIESVFEMQYGGVENEYNNNHVMFGVNITETTLGCYMYHRFGPSIQHYLSYSNDDTRKEGSFLTTVNVTEKGNPSHILQTIEFVPADKGFFPGSKGWKTASPGNLKFYDRTESSATLKKPQANSYVIRYADVLLDYAEAENEINGPAAAYAYVNRIRNRAKLPDLTPGLNKEQFADAIYKERGWEFVGEGLLYFDELRTNRIGKNVSDHVKYGNDNGINMYVNNPLQFVPSKNFLFKIPRYDLDSNPALIQNPDNVSN
>NZ_CP043612.1|WP_111378777.1|1647612_1650603_+|TonB-dependent-receptor
MKNKISHLLILIFSIFVHLTTLAQTKMVTGSITDSNGVPIPGANIAVKGSQTNTISDFDGKYSINASTGSVLIFSSTGSKTIEKTVEQSSIIDITLSDEVAELKEVVVVGYGTMKKSDLTGSIAQIKGDVLNTVTSSNPLEAVQGRAAGVAVLNNDSSPGSSPKIRIRGNGSVSAGNDPLIVVDGFPLVNSNLNDISSNDIESMEILKDASSAAIYGSRGANGVILITTKRGKKGQNNLEIVGTQGISTPTRLPKTLSRDSFVNFINDAYTYSTGKPVYSATNPAPNINTDWQDEIIQNMALMQNYSLSFSGGKENTTYLLSGNIFSQDGIVEASGFKKLTLRTNLNHEYKPWLTVGTHLQVGRSQRDIRNNPTGDIFRYGWPTIPVKNPDGSWYYATEDPAVSSYFEGTWNPVSEASEMTNEISTDRILGDVYAHFKIAKNLTFKTNYGVDISNEKQYEYYTSKSTAGIGSGNTGTGGQYYRRQSSQLTDNILSYANTWKDKHSLTATAVYSWQEYVYEDLGVKGSGFQNDATGANDITYADRASITNSSNKYSSKLISWTARTSYTYNEKYLITLTGRYDGSSRFGSNNKWGFFPSLGLGWNVDKENFLKNNSVISTLKLRASYGVTGNQEIGNYQSLSKLVKANYVYENNPIFGFVETIGNPDLKWERNIQYNAGIDLSLWKRFDLNLDFYQRQTSDLLYNVPIPTTSGYSSMLQNIGEVKNIGFEVTARVKVIDSNFKWDISGNFSKNKNEIVSLYGDVSRINVGSSSAGIAKYLIVGQPVNSVWARESAGIIKTQEQLTAYRQIRPTAQLGEEMYVDKNNDKIINNDDYVNIGTTSPDFFYGISTNLSYKNLTLDIYGQGATGLASDEDNNYMIFGENQIQNRNYIPTQYAYDRMWSPTNPSGNFPRAGAKDVYLSNRTNGDWNYFVVKNIKLAYNLSNVIKSVDWVKQLNVYVNAQNFINIANHRGYNPESGNVTSPYVKTMLIGFTAKF
>NZ_CP043612.1|WP_111378778.1|1646833_1647253_+|CBS-domain-containing-protein
MKKREPLSHIMTKSVITVNQNDDLKKVVEKLKANSIRHIPVVNGKEVVGIISRTDINRLTFGALFDGQDGADEAILEMLTISQVMTSKPKTVSSDTIIRDLAEIFVKEEFHALPVVDNGELKGIVTTTDVLKYFLEQYV
>NZ_CP043612.1|WP_111378769.1|1659934_1660795_-|ATP-synthase-F1-subunit-gamma
MANLKEIRNRITSVSSTMQITSAMKMVSAAKLKKAQDAITAMRPYAEKLTELLQDLSATLEGEIGGDYTTQREVKKVLLVAVTSNRGLCGAFNSNIIKEIKNRTEFYAGKQVDVFAIGKKGGDALIKTHKIHGHHNAIFDNLTFENVAGIADDLTQKFLTGEYDRIELVYNQFKNAATQIVQVEQFLPLAPINTDTAAASGDYIFEPGKEEIVLALIPKSLKTQLYKGIRDSFASEHGARMTAMHKATDNATALRNQLKLTYNKARQAAITSEILEIVGGAEALNG
>NZ_CP043612.1|WP_111378768.1|1660884_1662462_-|F0F1-ATP-synthase-subunit-alpha
MAEIKPAEISAILRKQVEGFESGATLEEVGSVLQVGDGIARVYGLSNVQYGELVEFDNGMEGIVLNLEEDNVGVVLLGPSTGIKEGSTAKRTQRIASLKVGEQMVGRVVNTLGFPIDGKGPIGGDLYEMPLERKAPGVIFRQPVTEPLQTGVKAVDAMIPVGRGQRELVIGDRQTGKSTVCIDTILNQKEFYDAGKPVFCIYVAIGQKASTVAGIAKMLEEKGAMAYTVIVAANASDPAPMQVYAPFAGAAIGEYFRDSGRPALIVYDDLSKQAVAYREVSLLLRRPPGREAYPGDVFYLHSRLLERACKVIADDGIAKNMNDLPDSIKSIVKGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDGDLFNSGVRPAINVGISVSRVGGNAQIKSMKKVSGTLKLDQAQFRELEAFAKFGSDLDSVTLNVIEKGKRNVEILKQGLNDPYTVENQVAIIYAGSKNLLRNVPVNKVKEFEADFLAYLNSKHKDTLNALKAGKLDDAITDVIEKAAKEVSAKYN
>NZ_CP043612.1|WP_111378767.1|1662499_1663033_-|ATP-synthase-F1-subunit-delta
MASTRAAIRYAKAILDLANSKGVAEAVNNDMKSIASAIETNQELSTFIQNPTTTVEVKESALLEVFANVNGVTKGLFRLLFENKRFEILDAIALEYNKLFDENNGVEVAKVTTAIPMDAALEAKVLAKVATLSDKKITIENVVDPSIIGGFILRIGDNQYNASVANRLQVLKRELSN
>NZ_CP043612.1|WP_095930604.1|1663037_1663538_-|F0F1-ATP-synthase-subunit-B
MDKLINDFSFGLFFWQALILVILILLLVKFAWKPIMESITAREEGIKNALLSAENAKREMENLQADNQRILNEARAERDAMLKEAREMKEKMIADSKNEAQEAGQKMIDQAKAAIESEKNAAMAELKSQVSTLSLSIAEKLLKEELSNKESQTKLVEKLLGDVKLN
>NZ_CP043612.1|WP_008465835.1|1663628_1663826_-|ATP-synthase-F0-subunit-C
MGTIPTLVGAGLVVIGAGLGLGKIGGSAMDAIARQPEAAGKIQTAMIIIAALLEGLAFAALILGK
>NZ_CP043612.1|WP_111378766.1|1663860_1665036_-|F0F1-ATP-synthase-subunit-A
MVISNKPLSFILAAFVASLPIMGFANQENDSTHVQTETTHEEKVVSHNAHEEGEHVALDPKAKVDAFIDHHLQDSHDFVFFSDEKENKHYGFPLPVILIDGGLKVFSSSKLHHGEEVAEVDGSYYKLVHGKIYKTDAAGTINFDEHGHPSNEKPLDFSITKNVVSMLFVSVLLFFMFTGLAKSYKKGPIPTGFGRVLEPLVIFIRDEIAVPNIGEKKYRKYMGYLLTVFFFVWILNLLGMTPLGINVTGNIAITVCLAAFTFIITQFSANKDYWGHIFWMPGVPVPMKIILAPIEILGTLTKPFALLIRLYANITAGHVVIMSLIAMIFVGKNLAADLPISLGLTLFISVIEILVAFLQAFIFTMLSSLFIGMAVQDHDHAHHHEDETAII
>NZ_CP043612.1|WP_111378765.1|1665154_1665547_-|hypothetical-protein
MLSKNYKPIFYLLCLALGTYIIHKAVFFFSEINTENFHYSLELLYFSFFAISSLLYLILLVVKKKNFEIVGMAFLFGTFTQMLLAYLALQPILKNKTGETNVEKVSFFITFVLFLLFQTLLTVRLLNEKR
>NZ_CP043612.1|WP_111378764.1|1665604_1665832_-|AtpZ/AtpI-family-protein
MEKEPNNDRRNKWLAFINIPFQMGVIIFVFSYFGTWLDEKHPSPKVYYNTIFVLVGVGVALYNVIRQVNDINKTK
>NZ_CP043612.1|WP_111368379.1|1665812_1666211_-|polymer-forming-cytoskeletal-protein
MFEKVKKNGTEQLGRTNRIVEGTSIVGDIVSKADFRLDGELIGNFTSQGKIVIGAKGAVKGEIICNNADIEGEFHGKIKVLETLNIKSTAQIHGEVAVGKLSIEPGADFTATCTMLAHSNPVIMLEDGKGTE
>NZ_CP043612.1|WP_111378763.1|1666223_1668836_-|gliding-motility-protein
MKKNTLKYSFIPIFLFFLIACSTKKNTFLARSSHSIGTKYNILYNGGIGLDKGLKSIQANNEDNFWKLLPIEKMQFDENFSEGEKAKNPDFEKAETKATKAIQKHSMNIGGRERNWQIDEAYLMLGKARYYDQRFIPAIEAFNYILYKYPESNNIYTAKIWREKTNMRLGNDAIALKNIKILLKKTDLDKQTYADANALLAEAYLNLEQKDSAVSKLKVAEQFTKSNEERARYRFILGQMYQAEGQRDSAIYFYNAVIDLNRKADRKYMMHAYAKKAQMFDYENGDKNMFIEAYNKLVENRENRPYYDLLFYEMGVFFEKNKDQENALLFYNKSLGRKSKDPYLMASAYRNIGNMYFKNTDYTMAAKYYDSTLVKLDPKTREFAFIEKNRKNLDNVIKYEAIAKRNDSIIKVYNLPPNEKKDYFENYIAELKKKDEAKRLLEEKEKERLANIDRNSQGEFSGNGAVNPNSLGKPVEPEGIGMPPGGNDNASTFYFYNPTTVAYGKLQFKKMWGSRTLGGNWRLAGVKSANDAAMNDTINTKEVANALKDTIVPEKYTVAYYVEQLPTSQAAMDSIGKERNFSYYQLGLIYKEKFKEYNLASDKLEQLLKNNPEEKLVLPSMYNLYKIYQITNPAKAEAIKAEISTKYPDSRYAHILNNKEDDPNSSPDKEYQKWYKLFEEEKFDEVLANIDNLINQYSGDDIVSKYELLKANTLGKVNGLDAYKKGLENVADNYPNSEEGKNAREILEKQVPVLEKLSFTTTDTKNWKILYRISNNDTKAVKRIEEAIRVFLLVENYERLTTSLDKYNKTESFVVIHGLKSEAYANDIAGVFRDDKKYKIPDQAIIISNDNYKIVQIKKNLDAYLAPKTP

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Crispr_ID: NZ_CP043612_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_7

2066315-2066523

Orphan

Consensus_repeat	Method
TTAAACGGATGTCCTGATACTGACGGTGACGGAATCGCTGATAAAGA	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP043612_7

>merge|NZ_CP043612|7|2066315-2066523|PILER-CR
TTCAACGGATGTCCTGATACTGACGGTGACGGAATCGTTGATGCTTCTGACGCTTGTCCAGATGTATTTGGTTTAGCTGCATTAAACGGATGTCCTGATACTGACGGAGACGGAATTGCTGATAAAGATGACGCTTGTCCAGATGTTGCTGGTTTAGCTGCTTTAAAAGGTTGTCCTGATACTGACGGTGACGGAATCGCTGATAAAGA

>NZ_CP043612|7|1|2066315-2066523|PILER-CR
TTCAACGGATGTCCTGATACTGACGGTGACGGAATCGTTGATGCTTC	TGACGCTTGTCCAGATGTATTTGGTTTAGCTGCATTAAA
CGGATGTCCTGATACTGACGGAGACGGAATTGCTGATAAAGATGACG	CTTGTCCAGATGTTGCTGGTTTAGCTGCTTTAAA
AGGTTGTCCTGATACTGACGGTGACGGAATCGCTGATAAAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111377598.1\|2054120_2054834_+\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|376822
NZ_CP043612.1\|WP_111377503.1\|2054964_2058366_+\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235681
NZ_CP043612.1\|WP_012022792.1\|2058373_2058754_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|274340
NZ_CP043612.1\|WP_109190909.1\|2059429_2059786_-\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|214939
NZ_CP043612.1\|WP_111377502.1\|2059013_2059394_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377500.1\|2061040_2064199_+\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|237554
NZ_CP043612.1\|WP_111377501.1\|2060302_2060899_+\|lipoprotein-signal-peptidase	unknown	unknown	gnl\|CDD\|237816
NZ_CP043612.1\|WP_111377488.1\|2075288_2076203_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP043612.1\|WP_111365665.1\|2059967_2060183_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377493.1\|2071642_2072017_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377489.1\|2074475_2074994_+\|ferritin	unknown	unknown	gnl\|CDD\|153113
NZ_CP043612.1\|WP_111377497.1\|2067119_2069882_+\|PD-(D/E)XK-nuclease-family-protein	unknown	unknown	gnl\|CDD\|378929
NZ_CP043612.1\|WP_111377494.1\|2071296_2071617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377492.1\|2072101_2072878_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP043612.1\|WP_111377504.1\|2051751_2054034_+\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|225829
NZ_CP043612.1\|WP_111377499.1\|2064281_2065475_+\|glycine-C-acetyltransferase	unknown	unknown	gnl\|CDD\|235893
NZ_CP043612.1\|WP_111377490.1\|2074029_2074386_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377495.1\|2070181_2070856_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP043612.1\|WP_162615477.1\|2070862_2071006_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377491.1\|2073045_2073849_-\|TIGR00266-family-protein	unknown	unknown	gnl\|CDD\|376704

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111377598.1\|2054120_2054834_+\|DNA-repair-protein-RecO	gnl\|CDD\|376822	pfam02565, RecO_C, Recombination protein O C terminal. Recombination protein O (RecO) is involved in DNA repair and pfam00470 pathway recombination.	4.18933e-17
NZ_CP043612.1\|WP_111377503.1\|2054964_2058366_+\|isoleucine--tRNA-ligase	gnl\|CDD\|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NZ_CP043612.1\|WP_012022792.1\|2058373_2058754_+\|molecular-chaperone-DnaK	gnl\|CDD\|274340	TIGR02890, conserved_hypothetical_protein, regulatory protein, yteA family. Members of this predicted regulatory protein are found only in endospore-forming members of the Firmicutes group of bacteria, and in nearly every such species; Clostridium perfringens seems to be an exception. The member from Bacillus subtilis, the model system for the study of the sporulation program, has been designated both yteA and yzwB. Some (but not all) members of this family show a strong sequence match to Pfam family pfam01258 the C4-type zinc finger protein, DksA/TraR family, but only one of the four key Cys residues is conserved. All members of this protein family share an additional C-terminal domain. Smaller proteins from the proteobacteria with just the N-terminal domain, including DksA and DksA2 are RNA polymerase-binding regulatory proteins even if the Zn-binding site is not conserved. [Unknown function, General].	3.65505e-10
NZ_CP043612.1\|WP_109190909.1\|2059429_2059786_-\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	5.94732e-08
NZ_CP043612.1\|WP_111377500.1\|2061040_2064199_+\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|237554	PRK13909, PRK13909, RecB-like helicase.	1.49757e-88
NZ_CP043612.1\|WP_111377501.1\|2060302_2060899_+\|lipoprotein-signal-peptidase	gnl\|CDD\|237816	PRK14788, PRK14788, lipoprotein signal peptidase; Provisional.	1.59972e-101
NZ_CP043612.1\|WP_111377488.1\|2075288_2076203_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.26194e-30
NZ_CP043612.1\|WP_111377497.1\|2067119_2069882_+\|PD-(D/E)XK-nuclease-family-protein	gnl\|CDD\|378929	pfam12705, PDDEXK_1, PD-(D/E)XK nuclease superfamily. Members of this family belong to the PD-(D/E)XK nuclease superfamily.	2.70498e-23
NZ_CP043612.1\|WP_111377492.1\|2072101_2072878_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.39566e-39
NZ_CP043612.1\|WP_111377504.1\|2051751_2054034_+\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|225829	COG3292, COG3292, Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms].	1.38015e-06
NZ_CP043612.1\|WP_111377499.1\|2064281_2065475_+\|glycine-C-acetyltransferase	gnl\|CDD\|235893	PRK06939, PRK06939, 2-amino-3-ketobutyrate coenzyme A ligase; Provisional.	0
NZ_CP043612.1\|WP_111377495.1\|2070181_2070856_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.52016e-31
NZ_CP043612.1\|WP_111377489.1\|2074475_2074994_+\|ferritin	gnl\|CDD\|153113	cd01055, Nonheme_Ferritin, nonheme-containing ferritins. Nonheme Ferritin domain, found in archaea and bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.	7.50221e-57
NZ_CP043612.1\|WP_111377491.1\|2073045_2073849_-\|TIGR00266-family-protein	gnl\|CDD\|376704	pfam01987, AIM24, Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.	9.25466e-81

>NZ_CP043612.1|WP_111377499.1|2064281_2065475_+|glycine-C-acetyltransferase
MYGKIKEHLQKELQTIEENGIFKKERIITSPQGAEITISTGETVLNFCANNYLGLSSHPEVVQAAKDAMDTHGFGMSSVRFICGTQDIHKTLEKKIADFYGTEDTILYAAAFDANGGVFEPLLGENDAIISDSLNHASIIDGVRLCKAARYRYENNNMEDLEQQLIKANEAGARFKLIVTDGVFSMDGLVAPLDKICDLADKYDAMVMVDECHAAGFIGATGKGTLEAKGVMGRVDIITGTLGKALGGAMGGYTTAKKEIIELLRQRSRPYLFSNSLAPAIVGASIKVFELLEKDTALRDKLEWNTNYFKEGMKKAGFDIIDGDSAIVPVMLYDAKLSQTMANELLKQGIYVIGFFFPVVPKDKARIRVQLSAGHEKEHLDKAINAFTVVGKMLKVI
>NZ_CP043612.1|WP_111377500.1|2061040_2064199_+|UvrD-helicase-domain-containing-protein
MQSPSFSIYDASAGSGKTYTLVKEYLKIILSSPKNDAYRNILAITFTNKAVHEMKSRIVGNLSEFAKDDPSPKAADLMEDLSRDTGLSIIKIKTKSQQIIKHLIHNYAAFDISTIDKFTHKVIRAFAHDLNLPMTFEVTLDTENLLVEAVDAIIAQAGEDETLTKLLIDFTMEKTDDDKSWDISREILDTGRLVLNENNRNEILHFQNKTIGEFVEIKKKMQGLCKELEETNEGLAAKAIELIDKNGIDPKSFSRGTFPNHLQSIKDGKFNPKNKTFHEFDDIAINKTAKDRALIENIIPELLQVLKEVYQNFEKRDFYKAFLKNITPLSLLNTVSNELAKIQSEQNVLSISEFNAIIHREIQNQPAPFIYERLGERYRNFFIDEFQDTSEMQWQNLIPLIDNSLSGLDDFGNKGTLMIVGDPKQSIYRWRGGKAEQFIELSKEEVAFFHHEKVVKHLDTNYRSYSEVIEFNNAFFKLISSEFSNEDYKNLYENHSFQNTNSKKGGYVDISFLPIIDKNDFADEDDVVEKSDLYVLATLNTIQEVVKQGFEYKDIVILTRKRDQGIAIANYLTEQGIPLLSSETLMIQNASEVRLIIHLLRYLNNNSDLESKANFLHFLASTKDLSMPIHDFIAMGMNHRFEKEFEEWLLTFDVSFSFEDVRKKSLYEAVEIIISKFILPSEGNAYVQFFLDIVLERDIRNQAGVADFLVFWDKNAEKFSIPSPEGNNAVRIMTIHKSKGLEFPVVIMPFADEDYNRKPKDKLWLDTEEIDLGVPKALVDNSSAVESFGENASAVFNLKKQEELLDNINVLYVALTRAEEQLYVISQSLKAKSDGEYPNNMASFFIKFLIHEGVYDEEKLNYEFGNKARLSKSSKTIDMVKSIPIVKEVLNPKNIKIAQREALMWGTHQQEAISYGNIVHEILAFVKDRSDIDLAVTKSLENGLITYDQKDQVLQTLNEIVNHSELNICFDANHTVLNEQTIVQKEGRILKPDRIVLLESKEAYLLDYKTGVPNAKYQQQIQEYQDAIEDLGYTVLKKALVYIGEEIEVVNL
>NZ_CP043612.1|WP_111377501.1|2060302_2060899_+|lipoprotein-signal-peptidase
MSLRKAYFLIFLVLIVDQLSKIYVKTNFVLGEEVVIADWFRIHFIENEGMAWGTKIPGEYGKLILTVFRIFAVVGIGWWLSDSIKKRHSTYLVVAIALIFAGAAGNIIDSVFYGVIFDDSTHNLATIFSPAPYGTWFHGLVVDMFYFPIWEGNLPEWLPLFGGKHFAFFNAIFNVADVAISTGVGILLVFNRRAFPKH
>NZ_CP043612.1|WP_111365665.1|2059967_2060183_+|hypothetical-protein
MAKVLKFKEVNSDVERRMKEFEKLRVKFKADVKKGEAKKLAAGKESKGIFKSISDFFSDSPKAPAKAAVKK
>NZ_CP043612.1|WP_109190909.1|2059429_2059786_-|roadblock/LC7-domain-containing-protein
MNEITTTLNDFLVSTKSTAALILNGKGKLITSLNLDYGDSIAAMSAAILSMSEKFLIDLEKGSLKQLYLKSAEGVIVGNKISGSNFIVAFSKEGSNLALLMRSTEEVSVELSKNSLLK
>NZ_CP043612.1|WP_111377502.1|2059013_2059394_-|hypothetical-protein
MSNDFLNVFLNEMKTNVNGFIAVAVTEIESGLSFGNLTVDPNFDPELAAAYNLEVVKAKLSAVKALNLNQDIEDILITLSNQIHIIDISPNKKFMIYLAADASKANLGMTRAILRKHKADVEKNLA
>NZ_CP043612.1|WP_012022792.1|2058373_2058754_+|molecular-chaperone-DnaK
MIDEITRYSDADLAEFKEIIQAKIKKAQEDLDLIKSAYMNDLNNGTDDTSPTFKAFEEGSETMSKEANSQLAIRQEKFIRDLKNALFRVENKTYGICKVTGKLISKERLKIVPHATMSIEAKNLQR
>NZ_CP043612.1|WP_111377503.1|2054964_2058366_+|isoleucine--tRNA-ligase
MSTKFTEYKGLDLPTVASEVLDFWKKENIFEKSVTTREGAEPFVFFEGPPSANGLPGIHHVMARAIKDIFCRYKTQKGFQVKRKAGWDTHGLPVELGTEKELGITKEDIGKTISIEEYNEACKKTVMRYTDVWNDLTEKMGYWVDMDDPYVTYKPKYMESVWWLLKQIYDKGLLYKGYTIQPYSPKAGTGLSSHEVNQPGAYRDVTDTTIVAQFKTLPETLPSFLQGFGDIHILAWTTTPWTLPSNTALTVGPKIDYVLVKTFNQYTFEPINVILAKNLVGKQFGKGYFVSEDDADFDNVKNGDKKLPYKILTEAKGADLVEIRYEQLLPYVLPYQNAENAFRVISGDFVTTEDGTGIVHTAPTFGADDAKVAKEAKPEVPPMLVLDENGTAVPLVDLQGKFTSHVGDLAGKYVKNEYYDAGQAPEKSVDVEIAIRLKEENKAFKVEKYVHSYPHSWRTDEPLLYYPLDSWFIKVTDVKDRMFDLNETINWKPKSTGEGRFGNWLKNANDWNLSRSRYWGIPLPIWRTEDKTEEVIIGSVEELYNAIEKSIEAGFQKENPFKGFEIGNMSESNYDLIDLHKNVVDAITLVSASGKPMKRESDLIDVWFDSGAMPYAQWHYPFENKDKIDGNKDFPANFIAEGVDQTRGWFYTLHAIGTLVFDKIAYKNVVSNGLVLDKNGIKMSKSKGNTIDPFKTIAENGPDATRWYMIMNANPWDNLKFDLEGIAEVKRKFFGTLYNTYSFFSLYANIDGFKYAEAEIPLNERPEIDQWIISELHSLIKFVDECYEDYEPTKATRAISDFVQENLSNWYVRLCRRRFWKGEYAKDKIAAYQTLYTCLLTISKLSAPVAPFFMDKLYRDLTASTGTEDFASVHLAEFPKFVENFVNKTLESKMQKAQTISSLVLSLRKKEMIKVRQPLQKVMIPVLDENQRAEIEAISDLVKAEVNVKEIELLDDASGILVKQIKPNFKALGPRFGKDMGLISKEIQGFSADQINQLDKQGTLDIVIAGNSVTLSLEDVEITSQDIEGWLVANSNGITVALDITLTEELKNEGIARELVNRIQNIRKDSGFEVTDKIKVQIKRDGILEDAVSKNEDYIKSETLTDELVFADTLENGTEIEFDDIRTIILISK
>NZ_CP043612.1|WP_111377598.1|2054120_2054834_+|DNA-repair-protein-RecO
MLVKTKAIVISSLKFQEKSLIVKCFTLSSGLKSYFVRDAFSSRKASQKIAYFQPFSILEIEAVHKNKGTLENFKEIKTAVPFQSIHTDIVKSTMVMFLSEMLHYSIQEEEKNEQLFLFLETALTWLDHHDEISNFHLILLLEITKYLGFYPDLSEVNLPFFEMNEGIFTLFQNGNVLSEHETNLFKKLLDLKFDNDQKVFHVLERQILLRILIDYYSLHLEGFKKPKSLEILKEVFS
>NZ_CP043612.1|WP_111377504.1|2051751_2054034_+|T9SS-type-A-sorting-domain-containing-protein
MKKVFFCSLFLLLIQLCEAQGELSWQGYFSFNEIKDISESATSVFAASENALFSKNTATNILKTTTTVDGLSGQTISAVYYSETFKKTIIGYENGLIILINDVDGSILKVVDIINKQLPANTKKINHFMEDNGLVYVSCDFGIVQFNLKTSQFGDTYFIGDNGVEISVKQTAMFNGFIFAATSGGIRKADKTNANLIDYKQWSVVNSGNWSSLEALDAELIAINDSGYIHRFNSNTFVGFLQLPQAAVDTRAKNHSLFVTTANTVYVYNNQMMLNRQITNSEVLDNTLNFSCATAVGNQIFIGTKEKGLFVSSLNTIAAFENNTPAGPVRNNIFAIDAGSSVLWAVYGDYDVSYNPYPLDNYGISKYNASGWLNIPYSEVYDAKSITRVLVNPNNEKQVYASSFFSGLVKVENDVPSFLYNEKNSGLESLTTGDPSYIDIRINATAFDKSANLWVTNSRIKNGLKVLKTNGQWGSYAMTSILDNAEESNYSSLVIDRNNVKWIGTNKDGVVGFNESGNVFKKMTFGVDAGNLPIADVRALALDTKNQLWIGTTKGLRVLSNVGSFQSESQLKANAIIITEDDLAQELLYEQFITSIVVDGANNKWIGTADSGVFMVSPNGQETKYHFTINNSPLPSNYVNDIKINAKTGEVFIATNKGLISFNGIATGANDDLSNAYVYPNPVRPNYTGTVKVAGLIDKANVKITDIEGNLVFETTSSGGTIEWDTTAFGKYKVASGVYMVFISAEDGGETKVKKVMIIR
>NZ_CP043612.1|WP_111377497.1|2067119_2069882_+|PD-(D/E)XK-nuclease-family-protein
MINDSFLQKIASVVIQDYVEKLSEITIILPNKRAKVFLIEALKKATSKTIIAPQITSIEDFVQDVASIRSVDSIELLFEFYEVYLSITEKKNQQSFELFANWAKTLLQDFNEIDRYLLDPSHVLSYLKDIEDIKRWGLEVDQKTKLLENYIDFWKLLPVYYESLYNHLLFKSIGYQGLIYREAVNNLNHFSNTIGNRTFIFAGFNALNAAEEKIVQHLLALDQAKIYWDADQAFLNDPYHDAGLFLRRFKESWKHYKSNVFDWIVDDFSEPKNIQIIGTPKTIGQAKLAGSIIENLIDQNPDASLDKVAVVLGEENLLVPVLYSLPASVGALNITMGYSGKNNPSQIFVAKLFKMHTNALSRKGGSYVFYYKDVLDILTHPLVEPYANAQRLVRIIKENNYTFITHHKILELHPEPSSFFNLLFEKWQSGSIAVLKNISALLITIKEHFSNDNEEEKIAKAFVYGVFKVINKLINYYSKHHHIDNIDTLHSIYKQIIDLAEVSFEGEPLRGLQIMGVLESRVLDFETVIITSMNEGKFPAGKSQNSFIPYDVKRELGLPTFKEKDAIYTYHFYHLLQRAKNIYLIYNTENDGLDAGERSRFITQLEVEKKSKHNITFDIYNPELPNTAYEPISVPKSELVMERLKEIAVNGFSPSALTSYIRNPIEFYFQKILRIREVEEVEENIALNTLGTIIHETLKALYEPFIGKFISESDLLNCFKLLDDEVLKQFKLVYKEGEIKKGRNLLAFEVAKRNVANFLKMELESVKNNEAIQIIALEQTFQREFIHPKLPFPVLIKGNVDRIERRDGRIRIIDYKTGKVEKSNVVLKTWNGLTQELKNDKIIQVLAYAFMYEKEAGELPIEVGIISFKNLKSGFLPFGFKEEKDLDAIVTPQILNSYLEEIANLLGEIFDINIPFEEKI
>NZ_CP043612.1|WP_111377495.1|2070181_2070856_+|ATP-binding-cassette-domain-containing-protein
MKKHILEISGIQKSFNDKLLLSDIYLKLETGQIIGLFGRNGSGKSTLLKIIFGIVPALDKSIFINGISKNNSSVLLNEIRYLHQNQFIPNHFSVFQTIRLSVDKQKIFVFCEDDFLKPLLNQKIKDLSFGELRYLQVKLMFFNQSKFVLLDEPFSGLSPKMIEIIMLLIKENSEEKGIILTDHNYKSVIGIATDLRMLKEGKLRVINKKAELVSEGYLANSTIF
>NZ_CP043612.1|WP_162615477.1|2070862_2071006_-|hypothetical-protein
MKTVDELRFDLNVKLEKFRRFRIENGHINTTASEEKSKKGFFKKIFS
>NZ_CP043612.1|WP_111377494.1|2071296_2071617_+|hypothetical-protein
MIDLQTLVQETGAESGLSFNIDGILNESVNLEYDGNVAAMIGMILKMCLEMSEDVNNGDLKQVMIKNNDGIVVASKNQDDNCVALLSKDLSKMGLLLRRMDSVFNN
>NZ_CP043612.1|WP_111377493.1|2071642_2072017_+|hypothetical-protein
MSDFLQNFQNDLKENINGFIAVSVTEVETGMSYCSLTVKSDFDPELASAYNLEVVKAKLNAIKALGLNQKINDILITLTDQIHIIDVSEDGRYFIYLAVDSTKANLGLTRATLSKYKKDITSKL
>NZ_CP043612.1|WP_111377492.1|2072101_2072878_-|alpha/beta-hydrolase
MKTLLYKNTKISYSDSGTGNTIVLLHGFLENKKMWKDYVDFFSEKYRVVTIDLLGHGESEPLGYVHEMEDNANAVNEVLEYLKIEKATIVGHSMGGYVGLAFAELYPQKIQKLVLLNSTSKEDSAEKKLNRTRAIKAVKQNYVSFVSLAIANLFSENNRTRLSEEIEKVKTEALKTPLQGIIASQEGMKIRKDREWLLKENRFPVLLILGKKDPVLNYEESLSQIEDTTAELISFEDGHMSQIENKEELKTTLSHFFE
>NZ_CP043612.1|WP_111377491.1|2073045_2073849_-|TIGR00266-family-protein
MQAHEIDYQIFGEEMQYVEIELDPQEIVIAEAGSFMMMENNIQMETIFGDGSQQQGSGLFGKLLNAGKRVLTGESLFMTAFLNQGNTKSKVSFASPYPGKILPIDLTEFQGKFICQKSSFLCAAKGVSVGIEFSQKLGRGLFGGEGFIMQKIEGDGMTFVHSGGTMAKKELAHGEVLKVDTGCIIGFTKDVDYDIEFIGGIKNSIFGGEGLFYATLKGPGTVYIQSLPFSRLADRIIASAPRSGGNSREEGSLLGGLGNLLDGDNRF
>NZ_CP043612.1|WP_111377490.1|2074029_2074386_+|hypothetical-protein
MALVSDLTTKVLFETEKGYSYQCDLTNSIIINFIDTVSSYKIQDFLIFQRKVNSVDILNMLYDLSDQSDAQLIETTKRNFSRNLTICEIVQLRDLLNGTKFTLTLHSMLCNIVNVELI
>NZ_CP043612.1|WP_111377489.1|2074475_2074994_+|ferritin
MKDLLRTSTSLVEGIEKILNLQAKLESDASNKYLAMAAWLDRNGYANTASYMYKQAEEEREHFLKVFKYITDMGGIAITPSVPEVQQEFASFREVFEIALQNEIAVTQAVNKVIAKCRAENDYATEDFMMWYVAEQREEEKNARRALELFDLINGNEADGKFQLDVQISKIG
>NZ_CP043612.1|WP_111377488.1|2075288_2076203_-|alpha/beta-fold-hydrolase
MNNFLMKKIFLLGFLLIATTIFAQSEGFALNNDGSKTYYKTFGKGEPLLIINGGPGMNSNGFEDMAKVLGKNQQTIIYDQRGTGKSKLSKLDPTTISMKLMADDIESLRKHLKIKKWNILGHSFGGMLGSYYATIYPNSINKLVLSSSGGVDLSLLKGPNLIESNLSQIEKDSMNYWNEKIEKGDTSHKARLGRGRAMAPAYVYDQKFVPIIAERLTQGNSTINGLLWADMQKMNFDCKSKLKNFKNPVLIIQGKEDIISNEIGELAKQTFPNSKLILLEHSKHYGWLDAREKYFSDINSFLKS

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Crispr_ID: NZ_CP043612_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_8

3489526-3489752

Orphan

Consensus_repeat	Method
ATTAAATTATCTAACATTGTTAAGTAAAAG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP043612_8

>merge|NZ_CP043612|8|3489526-3489752|CRISPRCasFinder
ATTAAATTATCTAACATTGTTAAGTAAAAGAGCGCAAATTTCTATACAGTTAAGCCTTTCCAATTTTATTCAAAATCAGTATTAAATTATCTAACGTTGTTAAGTAAAAGTCTAAAAAAAGAGCTTTTATTACCTTTATTAAATTTTCTAACAGTGTTAAGCGAAAGTTATAAAAAAAAGGATTTTATGTTATCCCGTTTAAATCATTTTACACTGTTAAGTAAAAT

>NZ_CP043612|8|7|3489526-3489752|CRISPRCasFinder
ATTAAATTATCTAACATTGTTAAGTAAAAG	AGCGCAAATTTCTATACAGTTAAGCCTTTCCAATTTTATTCAAAATCAGT
ATTAAATTATCTAACGTTGTTAAGTAAAAG	TCTAAAAAAAGAGCTTTTATTACCTTT
ATTAAATTTTCTAACAGTGTTAAGCGAAAG	TTATAAAAAAAAGGATTTTATGTTATCCCG
TTTAAATCATTTTACACTGTTAAGTAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111377148.1\|3492035_3492380_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|315619
NZ_CP043612.1\|WP_111377141.1\|3496721_3497540_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377158.1\|3479943_3480453_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|378981
NZ_CP043612.1\|WP_111377153.1\|3485120_3488285_-\|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223911
NZ_CP043612.1\|WP_111377145.1\|3494145_3494487_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377159.1\|3479448_3479916_-\|DUF1440-domain-containing-protein	unknown	unknown	gnl\|CDD\|369297
NZ_CP043612.1\|WP_111377143.1\|3495544_3495823_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377142.1\|3496003_3496696_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377155.1\|3482375_3482981_-\|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223736
NZ_CP043612.1\|WP_111377151.1\|3490802_3491102_-\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377157.1\|3480857_3481238_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|379266
NZ_CP043612.1\|WP_111377245.1\|3488297_3489515_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|273776
NZ_CP043612.1\|WP_111377146.1\|3493257_3494052_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|131350
NZ_CP043612.1\|WP_111377160.1\|3476779_3479050_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340849
NZ_CP043612.1\|WP_111377147.1\|3492581_3493007_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP043612.1\|WP_111377156.1\|3481573_3482305_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP043612.1\|WP_111377152.1\|3489763_3490357_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP043612.1\|WP_111377246.1\|3480631_3480841_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377149.1\|3491444_3491873_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380344
NZ_CP043612.1\|WP_111377154.1\|3483355_3484774_-\|TolC-family-protein	unknown	unknown	gnl\|CDD\|224455

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111377148.1\|3492035_3492380_-\|cupin-domain-containing-protein	gnl\|CDD\|315619	pfam12973, Cupin_7, ChrR Cupin-like domain. Members of this family are part of the cupin superfamily. This family includes the transcriptional activator ChrR.	8.91892e-22
NZ_CP043612.1\|WP_111377158.1\|3479943_3480453_-\|DinB-family-protein	gnl\|CDD\|378981	pfam12867, DinB_2, DinB superfamily. The DinB family are an uncharacterized family of potential enzymes. The structure of these proteins is composed of a four helix bundle.	5.11599e-12
NZ_CP043612.1\|WP_111377153.1\|3485120_3488285_-\|efflux-RND-transporter-permease-subunit	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_CP043612.1\|WP_111377159.1\|3479448_3479916_-\|DUF1440-domain-containing-protein	gnl\|CDD\|369297	pfam07274, DUF1440, Protein of unknown function (DUF1440). This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.	0.000193166
NZ_CP043612.1\|WP_111377155.1\|3482375_3482981_-\|Crp/Fnr-family-transcriptional-regulator	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.1288e-14
NZ_CP043612.1\|WP_111377149.1\|3491444_3491873_+\|cupin-domain-containing-protein	gnl\|CDD\|380344	cd02214, cupin_MJ1618, Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain. This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.	8.42474e-19
NZ_CP043612.1\|WP_111377157.1\|3480857_3481238_-\|DoxX-family-protein	gnl\|CDD\|379266	pfam13564, DoxX_2, DoxX-like family. This family of uncharacterized proteins are related to DoxX pfam07681.	5.48956e-15
NZ_CP043612.1\|WP_111377245.1\|3488297_3489515_-\|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.15306e-74
NZ_CP043612.1\|WP_111377146.1\|3493257_3494052_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|131350	TIGR02297, AraC-type_DNA-binding_domain-containing_protein, 4-hydroxyphenylacetate catabolism regulatory protein HpaA. This putative transcriptional regulator, which contains both the substrate-binding, dimerization domain (pfam02311) and the helix-turn-helix DNA-binding domain (pfam00165) of the AraC famil, is located proximal to genes of the 4-hydroxyphenylacetate catabolism pathway.	1.39796e-22
NZ_CP043612.1\|WP_111377160.1\|3476779_3479050_-\|glycosyltransferase	gnl\|CDD\|340849	cd03822, GT4_mannosyltransferase-like, mannosyltransferases of glycosyltransferase family 4 and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.	6.7836e-71
NZ_CP043612.1\|WP_111377147.1\|3492581_3493007_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.4765e-05
NZ_CP043612.1\|WP_111377156.1\|3481573_3482305_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	6.76202e-08
NZ_CP043612.1\|WP_111377152.1\|3489763_3490357_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.81692e-12
NZ_CP043612.1\|WP_111377154.1\|3483355_3484774_-\|TolC-family-protein	gnl\|CDD\|224455	COG1538, TolC, Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion].	7.64519e-68

>NZ_CP043612.1|WP_111377245.1|3488297_3489515_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MNPENARMPKELIRENVQPIKTTMKMKNVIITSFILALVLSSCADKNQAPTAPPPPVLPVLAITSANTTTDSEYPASIQGTVDVEIRPQVSGNLDRIYVDEGAYVSKGQTLFKINERPYREQLNNALASLHAAEAALINANLEVDKLTPLVQNKVVSDYQLKTAKASQKIAAANIEQAKAMVGTAKINLGYTNVTAPVSGYIGRLPKKQGSLVSATDVEPLTTLSDVHEVFAYFSLGETDFINFKEQYAGNSLGDKIKKLPPVTLILADNNAYPQTGKIDMVDGQFDKTTGAITIRATFPNKGGVLRSGNTGRIRLGLNHDDAILVPQAATVEMQDKVFVFTVGKDNKVTKMPITVVGKSGTNYLIKEGVKTGDQIVLSGIDKLQDGQAIQPEKSTKVAEVTNKK
>NZ_CP043612.1|WP_111377153.1|3485120_3488285_-|efflux-RND-transporter-permease-subunit
MFKIFIQRPVLATVISILLVILGVLGLTKLPLQQFPDIAPPSVLVTAVYPGANAETVLRSVAPSIEESINGVENMTYMSSTASNDGTLAITVFFKLGTDADQAAVNVQNRVAQATSQLPAEVVQQGIVTAKQQNSFIMAIGMYTDDEAKYDQTFVANYAQINIIPELKRIPGVGSASIFGGVKDYSMRVWLNPTQMSAYKVTPNEVMGAIQDKSLEAAPGKFGERSKEVFEYVIKYKGKLTKPEDYENIAIRSNADGSVLRLKDVARVELGAYSYNSLTRLNGKKGIVIGVIQLAGSNSNDIQIAINKMMEKASKDFPKGIKHNIFYSTKVSLDQSIEQVEHTLIEAFILVFIVVFIFLQDFRSTLIPAIAVPVAILGTFFFMQLFGFSINLLTLFALILAIGIVVDDAIVVVEAVHAKMEHKRLSPKIATHEAMHEITGAIISITLVMAAVFLPVGFMEGSTGVFYRQFAFTMAIAIVISAVNALTLSPALAALFLKDNHGAHDHDAPHEKKGFKEKFFSAFNSSFESLTNRYVGGLKFLIRRKWLSLGGLALITLATVVMVKTTPAGFIPTEDQGFIAIAVNTPSGTSLDGTQKVMTEAENTLKSLEASRFVTAISGFNLLTNSTSPSSAVIFVLLKPNEERGEVKNIDEFMNQVRGKLGGISGGSFFVFSFPTVPGFSNVEALDLVLQDKTGGKLDKFSGISQEFIGALMKRPEIAVAFTSFKADYPQLQLEVNDEKANQLGVNVKDILQTMQAYFGSAQASDFNRFGKYYRVVVQADIEDRADPTAIDRVFVKNKTGEMVPINTLVKLTRIYGSETASRYNLFNSISINAIPKPGFSSGDAIKAIEEVAKQQLPAGYGFEFSGQTREEISSGGQSATIFLLCLIFVYFLLAAQYESYILPLAVILSIPAGIFGVFVAIGLTGIENNIYVQVALVMLIGLLAKNAILIVEFAAQRRRSGQGLIAASIMAAKLRLRPIIMTSLAFVVGLIPMMSAKGPSAQGNHSISIGAAGGMLSGVILGLFIIPVLFIIFQHLQEKVSGKPIAVIHNEEK
>NZ_CP043612.1|WP_111377154.1|3483355_3484774_-|TolC-family-protein
MKNHITKIVTFAILITTLISCKVSKDIETPKDAFPENFRNASVSSDTTSIADVEWKNFFTEKDIIKLIDSAVARNNDLQIAEKNIEIAQYRFTQSKWGNVPQVNLFVNASTSNPSDNSFTGLNLNQAIGAKHIDDYSAGASLSWEADIWGKIKNQKKGAYAGYLQSEEVKKALQTNIVANVSRGYYNLLMLDAQLDIARQNLRLNDSTTNIIKLKYDAGQVTTLAIQQSEAQKLNSAQLIPLLEQNIAIQENVLSVLTGSFPDSKERTVKLSALEVKHNTAIGIPSSLVSRRPDVKSAELALKVANANVGITKADLYPALRITAQGGVNSFETSNWFNIPASLFGTVAGGLTQPLLNNKRLKTQYNIALAEREKAVLSFRQSVLVAVSEVSDALVKVEKLQQQETFLKEKVKTLQQAIKNANLLFKNGLAEYLEVLTAQANLLQSELELADIKRQQLTANTDLYRALGGGWK
>NZ_CP043612.1|WP_111377155.1|3482375_3482981_-|Crp/Fnr-family-transcriptional-regulator
MTSDQQKYLNNLKLYFESYAPISEKSWNLIEGLTDFQTIKKGEILLENGEICKNMYFIAKGILRTFITDEQGNFYNKNLFFENRLACSKVSSMLQTPSDFTIEALEDCILIQLNYKKYIQLITENDDLKNFYIAYLEKNWIIEKEQREVALVMQNATERYLNLLETHPTIADRVPLLHIASHLGITPTQLSRIRKSLEKHL
>NZ_CP043612.1|WP_111377156.1|3481573_3482305_-|GNAT-family-N-acetyltransferase
MNHINLIKDNIDNLTTLWKTAAIPLLSYHQNDFLEFSQIKNAGWPNRLWFREDITEKDLQQIQETIEKNPGLVVPYWDIFGSNSNEIFEKNGFSIRNQLAAMALKLDQKFMTPNILTFKRVLNEEDAKTWTDIYPLSFNYVISKETLVHNYENVKYFLVHFEEKPIGTLALFQTENIMGIHGVGVIPEMRKRGFAEEIMKFAINKAIDADCEYAQLQASALGKGIYTKLGFEDLFTITNYQLT
>NZ_CP043612.1|WP_111377157.1|3480857_3481238_-|DoxX-family-protein
MKTTKIIFWTTTILIFLFEGVMPALTSQTELAKEGIRHLGYPEYFGNALVVFKILGVLALIIPQVPGKIKEWAYAGFAFDFIFASISHFAVDGIGFQGFFPLIVFAVLIVSYVTYHKIQRYKNIAL
>NZ_CP043612.1|WP_111377246.1|3480631_3480841_-|hypothetical-protein
MIEVFKTNVQEESQCQVIIEKLLEHFPNSSINFDLEDCDKILRIHAPAISNTKIIAILNSHGYFCEALP
>NZ_CP043612.1|WP_111377158.1|3479943_3480453_-|DinB-family-protein
MKSAIQNIILETYSKLDDLISSFSKEEINIVPFEGSWTAGQTAQHIILAYSGLTTLFAGKTEKTTREPDKNIKGLDSIFLDYTTKYQSPENIKPPAIEYEKGTLLASVKKIQNDLYEAAETYDLTLTCLDAKIPGFENFTIYEWLHFAIIHTQRHTHQLKTIYEHIKKQ
>NZ_CP043612.1|WP_111377159.1|3479448_3479916_-|DUF1440-domain-containing-protein
MRSKVRTIVSSGLVAGTLDITAAILIYAGILHKTTAEKILQSIASGIFKKEAYTGGAEMTFAGLGLHFLIAFIFAWFYFKIFPYIPFFKINTLLSGVSYGFFIWIIMNLVVLPIVFPVLPEKKLDFPLLLSILIVICCVGIPIAFITRKYYAKWY
>NZ_CP043612.1|WP_111377160.1|3476779_3479050_-|glycosyltransferase
MKTISNKSKIVFLSTFPPTQCGIATYTQDTIKGITNVYGKSIKCEICELVTEPIEEPTQAFTLNTRIRDEYAKVAEEINQDETVKLVHIQHEFGLFSGNYGDHLLDFLNVIKAPVTFTFHSVIPNPNEELRTFVRLLLSYSNSVFVMTNKSKEILINDYEISEEIITCVPHGTHIVIYETPQQAKEKLNIEDRLVLSTFGLLGEGKNIETGLEALPKIIEKAPNALYLIIGKTHPNLIRDGVDAYRDKLEGLVKELNLQNNVRFVNKYLDTDELLEYLKATDIYMFTSKDPNQAVSGTFAYAMSCACPIVASKIPHTREVLTPDSGILCDIGNSDQFAAAAIKLIENENLRHEMGINSFTKMRASSWENVGITQMNTYKNLIKNPSEIKYSFPPIRLKHIKKLTTELGIIQFSKISIPDLDSGYTLDDNARALIAFCMHYKLTQDKDDLAYILIYLDFIQRCQKPKGDFINYVDQENREHIEQNAEVNLEDSNARAIWALGTVVSMSDILPEAITQKATRCLLNSLKWAENIQSPRSIGFATKGLYLYHSTIPNLYVAAIINKLNAKLLANYEDTATEDWQWFENYLTYGNGILPESMLYAYLVTNKPVYKKVALDSLDFLISKTFINGTFKAISNQSWHHKGSEPHEYGEQPIDVTYTIQTLNAFYNAFKTPEYKKKMRAAFNWFLGKNHLNQIMYNPVSGGGYDGLEKNNINLNQGAESSVCYLTARLLMEKLALSQSHVIPLMKSRSGIAINL
>NZ_CP043612.1|WP_111377152.1|3489763_3490357_-|TetR/AcrR-family-transcriptional-regulator
MASKDRILRQKEETRNNILGAAYDIVKDEGWNGLSMRKIADRIEYTAPIIYEYFSNKEAILEELTGKGFLKLAKELQTAKDKFEKPEDQLEAMWMTYWDFAFTNTEMYQLMFGVQMTCCAQRCSAQEAPYKLFTGVIAEIMKDSNPSEDIIKQKYFTFFSVIHGLIAINIINKSDILETINAQILKDAITGIIKSIQ
>NZ_CP043612.1|WP_111377151.1|3490802_3491102_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MNYKIIVSPIALTNIEEALEYYILKVSKKVALDFLNDYKKVYKALQINPFYQFHDTNYRYLPFKKFPYVAFFIVDELSKTVFLNAIFHTSQNPEKYPVR
>NZ_CP043612.1|WP_111377149.1|3491444_3491873_+|cupin-domain-containing-protein
MKTLTILKTTITVLVFQQTFSQETKKETPQYTIENCVNHFDINKATKTKVGYQYWFANKDFTQENTLKMSIVEPGKSTHAPHHHPEEEFFYILEGTAEFFLDGKTVTAGPNTSFYCPPNAEHGISNAGKTDLKYLVIKKDLR
>NZ_CP043612.1|WP_111377148.1|3492035_3492380_-|cupin-domain-containing-protein
METKITKSNELEWKPLQEEGVKTDGIYAKVLRFDASTNRPPTFFLKFEPGASYPNHVHPAGEEIYVLEGEVRSGKDQLKAGDYLYMPPGSTHSVFSRTGCTLLFMIPEEVVILK
>NZ_CP043612.1|WP_111377147.1|3492581_3493007_-|DoxX-family-protein
MKRYQDYAILLLRIAMAIGFLSAVSSRLGLLGKRSSGWENFLSYAESVNSFLPKSFIPSIAIISTFLESLFAVLLLIGYQTRKTAMGASILTFLFALAMTYSFGIKDPLDYSVFVFSMGAFLLATADKYRWSLDEYLLRIK
>NZ_CP043612.1|WP_111377146.1|3493257_3494052_-|helix-turn-helix-domain-containing-protein
MIDIKTFEQAEDLKYPRRVLKYVLLFCTSGEITLSVDENEYLITKNSVLTITSGQIHFIKNSSNATGFVLEFTYDFFCKNDNDIELIFHNSLFCHFAMNEVIKVDDDKLVVDALELIQQEIAQKPYQYLISIHSRIQLILIEINRSKIKLGEEIYKPDALFLHFLEAIRGNFDKNLSVNEFADLIGTTEAKLNELSKLHCNKTAQNIIFGLIISEAKRLFTYEKLSVKETAYALGFNDPFYFSNFFKKHTNISPKSYKEKVVQL
>NZ_CP043612.1|WP_111377145.1|3494145_3494487_-|hypothetical-protein
MPLTKKITELVSKKYNTNITIMGDYEGSNNTSILDDTNGTILVVSDRDQFYFKDQNRNLWLSVLDPFHIDGKQHHPELGDSYTLNHGVQYSFTTKEAIIDMASSYFEKHSDFV
>NZ_CP043612.1|WP_111377143.1|3495544_3495823_-|hypothetical-protein
MANFGRDALRFKYSWTTTEGDSKKVIGYPDNILLNRDEGYEVLHFINKYMTTRNLNNTLTNFNIIENSIKTTVPSNLRSQANIKAWLDSNLK
>NZ_CP043612.1|WP_111377142.1|3496003_3496696_-|hypothetical-protein
MNGKKITISLFLLGIILCLFTISIYLIKFGTLKFSDKTSDWVDFADYFSGILNPIIAILNLVFFAYLSFKIINIEDSRNNWTLQELARPYGDLLTESTVNSIELSLHNVGLGPLILTDFRVYKDADNSYKDFYYLINDIADQENISPDIKFKIDSFELSSTHGAIAKDKSICIFKIYFINDNMKENQEFIKLLRTKLDSYYISITYEDLYGREIECINERLSFNDWRFSS
>NZ_CP043612.1|WP_111377141.1|3496721_3497540_-|hypothetical-protein
MKNELKITDTSIEEKIKRELKAKPGSERDRIFSKFFGAALGGIPWVGGFLNILTDLHFDDQSKNNLLYEKWLEEHQNKMRLLGETLYEVVKKLNEFSEDINERLESEEYLQIVRKSFRTWDNADTFEKRELIRKLITNAGGQKIVDDDIIRLFLDWLNLYHEIHFSVIKVIYQNQSASRGEIWQELNGTYVREDSMEADLFKMLIRDLSTGGVIRQYRPTDYYGNFVKQKRTKTPSSGTLKSAFDDNEQYVLTNLGQNFVHYTMNELSTKIE

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Crispr_ID: NZ_CP043612_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_9

4566006-4566204

Unclear

Consensus_repeat	Method
GTAGACGCACTGCAGTGCGTCTCTACGA	CRISPRCasFinder
GGACATACTGGACGTAGACGCACTGCAGTGCGTCTCTACGA	PILER-CR

2 spacers

cas3

The CRISPR arrays of NZ_CP043612_9

>merge|NZ_CP043612|9|4566006-4566204|CRISPRCasFinder,PILER-CR
AGAGACGCACTGCAGTGCGTCTCACGTCCGTATATCGACAAAGATTTTTCCGTAATATTATTTTCCGTTGCGGATATACTGGGCGTAGACGCACTGCAGTGCGTCTCTACGACTTCCTGGGGTGATAAATGCGAATCTACGATATCATTTTCCGCTGTGGACATGCTGGATGTAGACGCACTGCAGTGCGTCTCTACGA

>NZ_CP043612|9|8|4566006-4566204|CRISPRCasFinder
AGAGACGCACTGCAGTGCGTCTCACGTC	CGTATATCGACAAAGATTTTTCCGTAATATTATTTTCCGTTGCGGATATACTGGGC
GTAGACGCACTGCAGTGCGTCTCTACGA	CTTCCTGGGGTGATAAATGCGAATCTACGATATCATTTTCCGCTGTGGACATGCTGGAT
GTAGACGCACTGCAGTGCGTCTCTACGA

>NZ_CP043612|9|2|4566008-4566204|PILER-CR
AGACGCACTGCAGTGCGTCTCACGTCCGTATATCGACAAAGATT	TTTCCGTAATATTATTTTCCGTTGCGGATATACTGGGCGTAGACGCA
CTGCAGTGCGTCTCTACGACTTCCTGGGGTGATAAATGCGAATC	TACGATATCATTTTCCGCTGTGGACATGCTGGATGTAGACGCACT
GCAGTGCGTCTCTACGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111378101.1\|4571223_4573332_+\|ATP-dependent-DNA-helicase-RecG	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|236794
NZ_CP043612.1\|WP_111378092.1\|4561131_4561899_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|182593
NZ_CP043612.1\|WP_111378089.1\|4554008_4554842_+\|flagellar-motor-protein-MotB	unknown	unknown	gnl\|CDD\|224279
NZ_CP043612.1\|WP_111378087.1\|4552481_4552934_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|372640
NZ_CP043612.1\|WP_111378214.1\|4563671_4565732_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066
NZ_CP043612.1\|WP_111378090.1\|4555714_4558051_-\|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl\|CDD\|273429
NZ_CP043612.1\|WP_111378091.1\|4558363_4561069_+\|T9SS-type-A-sorting-domain-containing-protein	unknown	unknown	gnl\|CDD\|275036
NZ_CP043612.1\|WP_111378098.1\|4567698_4568202_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378103.1\|4574271_4574616_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378102.1\|4573603_4574209_-\|PAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|369881
NZ_CP043612.1\|WP_111378093.1\|4562022_4562547_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378088.1\|4552955_4553975_+\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|133029
NZ_CP043612.1\|WP_111378099.1\|4568204_4568600_-\|DUF4348-domain-containing-protein	unknown	unknown	gnl\|CDD\|372983
NZ_CP043612.1\|WP_111378097.1\|4567316_4567697_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378094.1\|4562631_4563540_-\|patatin-like-phospholipase-family-protein	unknown	unknown	gnl\|CDD\|366777
NZ_CP043612.1\|WP_111378096.1\|4566572_4567316_+\|diphthine--ammonia-ligase	unknown	unknown	gnl\|CDD\|238952
NZ_CP043612.1\|WP_111378104.1\|4574666_4575521_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378215.1\|4569169_4570933_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378213.1\|4555011_4555632_-\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|223088
NZ_CP043612.1\|WP_111378100.1\|4568599_4569139_-\|DUF1697-domain-containing-protein	unknown	unknown	gnl\|CDD\|377954

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111378101.1\|4571223_4573332_+\|ATP-dependent-DNA-helicase-RecG	gnl\|CDD\|236794	PRK10917, PRK10917, ATP-dependent DNA helicase RecG; Provisional.	0
NZ_CP043612.1\|WP_111378092.1\|4561131_4561899_-\|TSUP-family-transporter	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	3.17584e-34
NZ_CP043612.1\|WP_111378090.1\|4555714_4558051_-\|UvrD-helicase-domain-containing-protein	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP043612.1\|WP_111378087.1\|4552481_4552934_+\|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein	gnl\|CDD\|372640	pfam13588, HSDR_N_2, Type I restriction enzyme R protein N-terminus (HSDR_N). This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.	2.82929e-54
NZ_CP043612.1\|WP_111378214.1\|4563671_4565732_-\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.63628e-125
NZ_CP043612.1\|WP_111378089.1\|4554008_4554842_+\|flagellar-motor-protein-MotB	gnl\|CDD\|224279	COG1360, MotB, Flagellar motor protein [Cell motility and secretion].	1.00432e-32
NZ_CP043612.1\|WP_111378091.1\|4558363_4561069_+\|T9SS-type-A-sorting-domain-containing-protein	gnl\|CDD\|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	2.54027e-10
NZ_CP043612.1\|WP_111378102.1\|4573603_4574209_-\|PAS-domain-containing-protein	gnl\|CDD\|369881	pfam08447, PAS_3, PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.	7.03118e-13
NZ_CP043612.1\|WP_111378094.1\|4562631_4563540_-\|patatin-like-phospholipase-family-protein	gnl\|CDD\|366777	pfam01734, Patatin, Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.	8.35657e-20
NZ_CP043612.1\|WP_111378088.1\|4552955_4553975_+\|glycosyltransferase-family-2-protein	gnl\|CDD\|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.93391e-42
NZ_CP043612.1\|WP_111378100.1\|4568599_4569139_-\|DUF1697-domain-containing-protein	gnl\|CDD\|377954	pfam08002, DUF1697, Protein of unknown function (DUF1697). This family contains many hypothetical bacterial proteins.	1.56869e-49
NZ_CP043612.1\|WP_111378099.1\|4568204_4568600_-\|DUF4348-domain-containing-protein	gnl\|CDD\|372983	pfam14254, DUF4348, Domain of unknown function (DUF4348). Two structures have been solved form this DUF, Structure 4mjf and Structure 3sbu. TOPSAN records that both proteins are the only structural representatives of Pfam PF14254, DUF4348. There are no other significant hits in FFAS. DUF4348 has ~200 proteins, all from Bacteroidetes, and all with a single domain architecture with just one DUF4348 domain. There appears to be a possible gene duplication in the protein as the N-terminal domain (approx residues 25-174) and C-terminal domain (approx residues 175-286) superimpose quite well with ~1.9A r.m.s.d. and ~30% sequence identity.	5.6721e-05
NZ_CP043612.1\|WP_111378096.1\|4566572_4567316_+\|diphthine--ammonia-ligase	gnl\|CDD\|238952	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins is predicted to bind ATP. This domainhas a strongly conserved motif SGGKD at the N terminus.	6.16328e-63
NZ_CP043612.1\|WP_111378213.1\|4555011_4555632_-\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	9.36078e-59

>NZ_CP043612.1|WP_111378214.1|4563671_4565732_-|M1-family-metallopeptidase
MKYIFLLFTSFLFAQQTQHVDFKSVSGQLSVNPKDKLISGTVDFQFEVLKDCDTISLDAKNMEFSNVKINENEIMFINTNKELKLVFPFKKGQNHLIFNYTAKPKQALYFVDMGNDEVQIWTQGQGRYTSNWFPSFDDVNEKLIFNLGISFDKDYQVVSNGVLKEKIANGSLNHWQFEMEKPMSSYLLMLAIGKFDKKEFKSKSRIPLEYYYEPKDADRFEPTYRYSKRIFDFLEKEIGIKYPWKINRQIPVRDFLYAGMENTTSTLFATRYVVDSTGFCDRNYTNVDAHELAHHWFGDLITAESSTHHWLQEGFATYFALLAEKDIYGDDYFYSKLYDTAQQIKFASRTDTIPVLNPKASSLTFYEKGAWALFVLHESIGDKAFKKAIKSYLNKYAYQTVNTQKFFDEIKKVSDFDLEKFQKTWLESTAFDTPTANALLSKNKAIQKRLEIDKLKKTPFAEKRDILKTTLESDVYQSVKEAVVDQLENEKYEDKKSLLLLALQTNNIKVRQNLAGSLTQIPEDFRANYETLLDDKSYQTQEIALYWLWRNFPNHRTEYLDKSKNWIGFNDYNLRTLWLSLALSTPNYTNEQDALVNELIAFSSTKYEATTRQNALEKLIAFKIINDQVLSNLVGATTHHMWQFSKFGRDTIRLLLKNPEMRASFNRILPNLTPDEQFQLNRLLKE
>NZ_CP043612.1|WP_111378094.1|4562631_4563540_-|patatin-like-phospholipase-family-protein
MRALVISGGGSKGAFAGGVAQYLIEEKKHEYDLFLGTSTGSLLIPHLALGHIKKIHSVYTNVTMSSIFNICPFVVKTKDGVDIVTINHFNVLRQFFKGKRTFGESKGLKKYIQNNFSLSDFNKLKKLKTDVIVTVTNFTKNESEYKSVKDCTYEEFCEWSWISSNYVPFMSLVEKNNCEYGDGGFSSLVPIREAINRGATEIDVIVLETEVNTTKTVIGKNPFSLMIDLFRIALDQVEKHDIAIGKLMANNKNVKLNLYYTPIKLTDNALIFNKEVMKEWWKQGYEYAQNKSEVMSDNKILI
>NZ_CP043612.1|WP_111378093.1|4562022_4562547_+|hypothetical-protein
MDFNKIIELASYTLPALVTGVVAYRFFELHIKNNDRKRAFLLNKQAHKESLPVRLQAYERMTLFLERINLTKLLIRIAPISQNKNDYENYLIDLIEQEFEHNLTQQIYMSEECWTIITTAKNATIQMIRKAAMSDKVENADKLREVILNDLLEKQSPSNAALSFIKSEVAELWY
>NZ_CP043612.1|WP_111378092.1|4561131_4561899_-|TSUP-family-transporter
MDSYIILFLCLAAFAAGFIDAIVGGGGLIQTPMGLILLPNLPVSTVVGTLKIPAFSGTAFAAFQYLKKVVIQWKLLIIMMCLAVPSAFLGSTILTLVSNDFMKPLLLVVLSLLFVYTYAKKNFGQHVAKDHSAATQIMYAVVISIIVGFYDGFIGPGTGSFFVVAFIALLGFDFFHASANAKMVNLATNFGSICLFMIKGKIIWAIAIPMAISNGLGGWLGAKLAINKGNGFIRIFFLIVVVGTLIRFAYDIFFK
>NZ_CP043612.1|WP_111378091.1|4558363_4561069_+|T9SS-type-A-sorting-domain-containing-protein
MRKNYLLALLLLTVKLIAQNPEIDHTFNTKDDGIYHQIIGSRAVVLSNNKILSVFERYYDYNVMLLNPDGSPDKTFNTANSFSENEIRIFANSSGAFLTLDYDNKLKAFNADGTLNPRFPVTIFGMVSSTPVQIKNIIYQDDGKVIIHGVFETVNDVYTGGCVRLNLDGTIDDTFKLQSGGYKLIIQSDGKYVILGSATTISRYLENGKIDPTFKVIATVDPKLNFVTNGFETENNSSIDDIIVQPDGKIIAVGCNYKENGRTVAYQIVRLNADGTRDTSFKSLDSRTDRVVKVYLQKDNKIIINVGNSTFTRLNTDGSIDATFKYSNTVSLLNKGTLFFQEDKMIINADYKDSMGMTRTEIHRINSDGSLDLSFNPSSGPNLLFDQWDERYAYPFAAKVLLDQKILLAGDFTTYNDNIVQNVCRINQNGEYDSSFKLDPNVKINALSSQNDYLIISQPDGKILLMHNNAITANGISKSLIRLNSDGSLDKSFNFEDYSSRITDVKLLENGKFLVMGRSGIFVKNGTNYGTTINTVLQLNPNGSIDNNFNGVFNQIPVGIFPLSDKKFLISFYRENTVYDYDAVIKFNEDGSKDSSFKVGFQPFYNVKELSDGKLLALVDQKITRINTNGSVDTSFTPYSIAKTYSNTYDRFDFYQNGEINVFYSTYETDSTTKLTLSEEGKLLNTTIYKSGSQFEIQNCEDIIFYGSFDTVDKNTKHNIFRYKSSNSTSTPNPAGEIFQPFTYGQTLADLTIAGADLKWYTQQSSCGINSKLTNKGKSEDVLPSSTLLVNGTTYYASQTINNTESSYRLPVTVYSATLGVKENQLPSLITYPNPVKGIYSISNNENITKIEIYNLLGQLISSNIYDKKNLEIDFTTLTSGLYFAKIYVEDKSAIIKIIKN
>NZ_CP043612.1|WP_111378090.1|4555714_4558051_-|UvrD-helicase-domain-containing-protein
MQKYIDQLNEAQRAPVLQKDGPMIIIAGAGSGKTRVLTIRIAYLMHQGIDAFNILSLTFTNKAAREMKHRISDIVGASEAKNLWMGTFHSIFARILRAESELLGYPSNFTIYDSQDSARLISSIIKEMQLDRDIYKPKQVLGRISSYKNSLITVKAYFNNPELQEADAMAKKPRLGEIYQQYVERCFKAGAMDFDDLLLKTNELLTRFPEVLAKYQNRFRYILVDEYQDTNHSQYLIVRALSDKFQNICVVGDDAQSIYAFRGANINNILNFQKDYEGVVMYRLEQNYRSTRNIVEAANTVMEHNKTKLDKVVWTANEFGPRIKVHRSLTDAEEGRFVASTIFEQKMQHQLHNGSFAILYRTNAQSRAMEDALRKRDIPYRIYGGLSFYQRKEIKDVLCYLRLVLNPKDEEALIRVINYPARGIGDTTVEKLTIAANHYKRSIWEVMVNIDKIDLKLNAGTKNKLKDFVTMIQSFQVIDQNQDAFYLTDHVAKKTGLVQELKKDATPEGMAKIQNIEELLNGIKDFTEGQREIDGARGALSEFMEDVALATDLDKDTNDEDRVALMTIHLAKGLEFPHVFVVGMEEDLFPSAMSMSTRSELEEERRLFYVALTRAEHQAYLTYAQSRYRWGKLTDSEPSRFIEEIEDQYLEYLTPAETNYRYKSPIDGDIFGDVDKSKLRLNKPVGGTPPAHITKGEPKPDLNIRKLKPVSGNAPSNGNSNLFDSKLTVGNVVMHERFGKGEVINLEGVGADRKAEIKFEVGGIKKLLLRFAKLDVVG
>NZ_CP043612.1|WP_111378213.1|4555011_4555632_-|threonylcarbamoyl-AMP-synthase
MAEFIKIYPDKPSEAAIAKVVKVLQNGGLVIYPTDTVYGLGCDITNSRALEKIAKIKGVKLDKAKFSFICHDLSNLSDYVRQIDTSTFKILKRALPGPYTFILPGNNNLPKEFKKKTTVGIRVPDNNIILEIVRQLGNPVVSTSIRDEDDVIEYTTDPELIFEKWQHLVDMVIDGGYGDNVGSTIIDLSEHEPVIVREGKGDIDIL
>NZ_CP043612.1|WP_111378089.1|4554008_4554842_+|flagellar-motor-protein-MotB
MRKIVIALSVLMALTSCVSKKKYAELEAKNKETQDLLNSCTVKLNTCLEEKAGLAATAESYKQHNQDLINSSKDLTILTTKGAENLEKSLESLKEKDLKISRLQDALTKKDSVTLALVTSLKGAVGINDPDIEINVEKGVVFISIADKLLFKSGSYEVSDKAKTVLGKVAKVVNDKPDFECMVEGHTDNVPYKSNGIILDNWDLSVKRSTSIVRVLTNDLGVNPAKLIAAGRSSYVPLVSNDTAEDRARNRRTRIVVMPKIDQFYDMIEKEMKKQAK
>NZ_CP043612.1|WP_111378088.1|4552955_4553975_+|glycosyltransferase-family-2-protein
MDKIAVVILNWNGVKLLEQFLPSVIQFSEGAAIYVADNDSTDNSVAFVTEKFPTVKIVKNSGNHGFAKGYNDALQHINAEIYALVNSDIEVTENWLKPILETFEQEKQTAIIQPKILDFKNKEYFEYAGAAGGFIDKYGFPFCRGRVFETVEKDNGQYDDNIELFWASGACFFIRKNVYHELGGFDESFFAHQEEIDLCWRAANEGHIIKYNSQSVVFHVGGATLQQGNPKKTYLNFRNSLLMMVKNLPKRGLFWVIFFRMVLDGIAGIRFLTQGKFAHTFAILKAHFSFYCLSLKYFKKRKDFQIQQYYMVKSIVFLYYIRKLALFKEIFNSIQNIKS
>NZ_CP043612.1|WP_111378087.1|4552481_4552934_+|type-I-restriction-enzyme-HsdR-N-terminal-domain-containing-protein
MLKLNFPAYTFRFKNSENKVSIFDEIRKKFIILTPEEWVRQHVVHFLMHEKKYPKSLINVEKVLTVNGLRKRYDVVVFNSDGSIHILVECKAPEVKISQATFDQIARYNMTMQARFLNVTNGLNHFYCQMDFENEKYEFLRNLPDYKENH
>NZ_CP043612.1|WP_111378096.1|4566572_4567316_+|diphthine--ammonia-ligase
MSTPQKALFNWSSGKDSALALYKTLQNSDFKIEYLLTSVNKQYQRISMHGIRVELLQEQAQSIGIPLKILEVPEMPTMEVYEKVMTETLTELKQDGITHSIFGDIFLEDLRQYRENQLAKIGLKGVFPIWKIPTRDLIEEFISLGFKTIVVCVNEKYLDKSFVGRIIDQDFINDLPENVDVCGENGEFHTFTFDGPIFSKPIDFEIGEIVYRKYEKPEKQDSSNTACDSNDETAFDFGFWYCDLIHK
>NZ_CP043612.1|WP_111378097.1|4567316_4567697_+|hypothetical-protein
MKFFFKLVLLILVSFSLQSCLVSRCERPQITGYIYDAETKRSIENCKVGETFTQSNGYFSLKEKRYRQFTFFGFEAPTLAVNEAIEKENYQSKSIKFMQPFGGGMKKGAFHNADTIYIKKTILKTN
>NZ_CP043612.1|WP_111378098.1|4567698_4568202_+|hypothetical-protein
MDLKESEEVKKVVFFLKEIGIDIIEKELGETFLPGLDLGSNCIYIDYNKLLYPGDILHEAGHLAVTIPAERKLVGTTEISKDWPTQGDEITAILWSYAALHHLDLSPEFVFHPNGYKGNSEWFISNFTTGNYMGLPLLEWMGLCLGNEKAEKEQKMPFPAMQKWIRD
>NZ_CP043612.1|WP_111378099.1|4568204_4568600_-|DUF4348-domain-containing-protein
MKKCFFIMFLLGLSSVALAQTSKATSEDFNEFFKKFNSDTKFQISRVIFPLKYKANNDDFELSDYTMAKEGYKVLHLNNKSDEKYLKRTLLVKKNKATLEQRGLDNGIYIDYVFELKENKWFLKTLVDQST
>NZ_CP043612.1|WP_111378100.1|4568599_4569139_-|DUF1697-domain-containing-protein
MKTHLALLRGINVSGHNMMKMEALKAMLENLGFQNIRTYLQSGNVFVDSEEDASKVGFMIKQEIFKVFGHEVPVVMITKENLESCFANNPFLKEKDIDTKKLYVAFVSTTLKKESINDLKISQFKPDEASIDENRIFIKYDIGAGKTRFDQKYIEKKLNVTATIRNWNTVTNLLKMYNE
>NZ_CP043612.1|WP_111378215.1|4569169_4570933_-|hypothetical-protein
MKEEKVPFETMVFSGITFKVINRHEAHNIIGDLTDFNNQKIYNVFEDTWRFPDYEENPIFLLAENDVEMDLFEMDFSTEEHPDIFILGFIFKGNLTVSKLISSYDTDNSPALIVLGKTTTVNINLFGSVHYLGGGLQCDTLAGEYNHGELFVKGDLTAWLIYSDDMLFHFERFTDVQAIISANRPDVLICSNVQDTDGSIITVENYLPSTHKLSDIVEDSFIENSDYNEEILGNNYLDVFKEGLSILDYDKKEKYMYADFRNQFINMVEVLSETEELKENGKIVRHISGTTYLFIPFDYEGKKYSQISEEISNGFNIRMRALWCHEDQEIMIILEYLDENGDPKYQWMNDENAPGIEFFCVKNAVMKTFEILTAEVVEEDDEEDETEYADYSNRFSLEEYASQFGNYKLPEDLVKLYEFEQEYGVETYSECFGLTITDDKTGIKTWSEEKEFYNSFIEFAGANGSGSSYAYWIIDNDLNNCPIVVFGDEGGVHVVAENTQKLIQLLTLDTEISVDFDKAYFYQDEEYYEESENREEFREWVKEEFNLNAVETNEEADEIVEEAQRKYKEKFNDFLVKFGIEISEEDE
>NZ_CP043612.1|WP_111378101.1|4571223_4573332_+|ATP-dependent-DNA-helicase-RecG
MSNNLFETPIEYLKGVGPSRGQLLRKELGIHKYGDLVNLFPNRYIDRTRYYKINELQNTGSEVQIIGKIINIKTVEFAKNKKRLVASFVDDTGQIDLNWFQGHKWIRESLKLNEPLVIFGKCSLYGSQFSMAHPEIELLSEHERSLRSAMQPVYPSTEALANKGISNRTINKLMEQLFLETQALFTETFPPFLIEELKLIPKRAALFNIHFPKSAAILAKAQFRLKFEELFFIQLQLITKNLIRKHKIKGHPFDKVGELFNEFYKNHLPFDLTNAQKRVIKEIRTDMGSNAQMNRLLQGDVGSGKTIVAFMSMLLAIDNGFQACLMAPTEILANQHFLGLSEFAKTLNINIRILTGSTKTSERKIIHEELESGELKILIGTHALLEDKVQFQNLGLAVIDEQHRFGVEQRSKLWKKNDIPPHVLVMTATPIPRTLAMSLYGDLDISVIDELPPGRKPIQTVHRYDSNRLKVWKFLRDEIAKGRQIYIVYPLIQESEKMDYKDLMDGYESISRDFPLPQYSISILHGKMKPADKDSEMKRFSEGKTDIMVATTVIEVGVNVPNASVMIIESAERFGLSQLHQLRGRVGRGAEQSYCILMTGHKLSSDSKTRMETMVQTNDGFEIAEVDLKLRGPGDLMGTQQSGVLNLQIADIVKDREILSLARNYAMKILKEDSALQKPEHAILRNIFIELTKKKNIWNYIS
>NZ_CP043612.1|WP_111378102.1|4573603_4574209_-|PAS-domain-containing-protein
MDTRLHRPTPSDREVDWNKNKVLLSKTDKKGTILYANEDFIDVSGYDEFELVGQPHNIVRHPDMPKVIFKFLWDSIKSSENIHVIIKNMAKTGRYYWVVTDFKIIADTDGEIVGYFGTRKSVPNEIIVKFIEPLYKKLLQIEETSGMHASEEYLVGFLEERKKTYMEYIDHLIATGKDDKNKISKGLFSGLFEKKNDVKKK
>NZ_CP043612.1|WP_111378103.1|4574271_4574616_-|hypothetical-protein
MFKYDLPTAVPTLHNLKKIIEDFLNESITLDSIEKIKAQSDFEIEVKEIFKNYQTSSHVYDLDFQYKKLIQIMNDIRQLNLAVNNEIPEWLENELETVFRKIRNILLVLEIESN
>NZ_CP043612.1|WP_111378104.1|4574666_4575521_-|hypothetical-protein
MKAKASLNEQDYLHSFMSTMTQKSDTIINYVLAVYFLLGIGLSFKYDTFEIGVGVGTLNLLLYYSAKFFMKNSKFYQYVLSIVLAIFMAQYIYQMHGMFEMHFTVFIASTILIIYQNWKLQIPLTLLVVLHHAGLAYLQNYIYNDANGLQVYFSQVNFDLETLIIHTVLAAVVFFMNGYWAYYFKEHSENHISKISDEYELENMKLASAKYSSMSATKDYNDFIHRTTLDLKLPVNSVLKLIDVSKGHTDNDKLLTYLEMMRESAKKIDDLVNDIHVKSTNSKH

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Crispr_ID: NZ_CP043612_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_10

5121518-5121617

Orphan

Consensus_repeat	Method
AAGTAAAAAATCACAATCATTTCCTTTATAGCAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_10

>merge|NZ_CP043612|10|5121518-5121617|CRISPRCasFinder
AAGTAAAAAATCACAATCATTTCCTTTATAGCAAAAAAAATCTATTTCATAAACTAGAGTATTCGAAGTAAAAAATCACAATCATTTCCTTTACAGCAAA

>NZ_CP043612|10|9|5121518-5121617|CRISPRCasFinder
AAGTAAAAAATCACAATCATTTCCTTTATAGCAAA	AAAAATCTATTTCATAAACTAGAGTATTCG
AAGTAAAAAATCACAATCATTTCCTTTACAGCAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111377006.1\|5125928_5126783_+\|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|239569
NZ_CP043612.1\|WP_111377011.1\|5130955_5132245_-\|conjugative-transposon-protein-TraM	unknown	unknown	gnl\|CDD\|274779
NZ_CP043612.1\|WP_149229166.1\|5123441_5124440_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|308001
NZ_CP043612.1\|WP_111376995.1\|5106203_5106917_-\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|226584
NZ_CP043612.1\|WP_111377010.1\|5130099_5130939_-\|conjugative-transposon-protein-TraN	unknown	unknown	gnl\|CDD\|163492
NZ_CP043612.1\|WP_111376996.1\|5106922_5108302_-\|beta-glucosidase	unknown	unknown	gnl\|CDD\|370812
NZ_CP043612.1\|WP_111377003.1\|5121852_5122878_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|377306
NZ_CP043612.1\|WP_111377007.1\|5127413_5128295_+\|restriction-endonuclease	unknown	unknown	gnl\|CDD\|377369
NZ_CP043612.1\|WP_111376999.1\|5115939_5117124_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680
NZ_CP043612.1\|WP_111377008.1\|5128625_5128922_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377092.1\|5113092_5115837_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|197715
NZ_CP043612.1\|WP_149229165.1\|5122995_5123379_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111377005.1\|5125582_5125954_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376540
NZ_CP043612.1\|WP_111377002.1\|5120833_5121436_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224854
NZ_CP043612.1\|WP_111377009.1\|5128927_5130067_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111376997.1\|5108377_5109835_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl\|CDD\|185760
NZ_CP043612.1\|WP_111376998.1\|5109839_5112848_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl\|CDD\|274948
NZ_CP043612.1\|WP_111376994.1\|5103809_5106110_-\|beta-glucosidase-BglX	unknown	unknown	gnl\|CDD\|185053
NZ_CP043612.1\|WP_111377001.1\|5119577_5120651_-\|magnesium/cobalt-transporter-CorA	unknown	unknown	gnl\|CDD\|213362
NZ_CP043612.1\|WP_111377000.1\|5117427_5119521_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111377006.1\|5125928_5126783_+\|RNA-directed-DNA-polymerase	gnl\|CDD\|239569	cd03487, RT_Bac_retron_II, RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	3.73514e-56
NZ_CP043612.1\|WP_111377011.1\|5130955_5132245_-\|conjugative-transposon-protein-TraM	gnl\|CDD\|274779	TIGR03779, Bac_Flav_CT_M, Bacteroides conjugative transposon TraM protein. Members of this protein family are designated TraM and are found in a proposed transfer region of a class of conjugative transposon found in the Bacteroides lineage. [Cellular processes, DNA transformation].	1.73072e-139
NZ_CP043612.1\|WP_149229166.1\|5123441_5124440_-\|hypothetical-protein	gnl\|CDD\|308001	pfam02151, UVR, UvrB/uvrC motif.	0.000709367
NZ_CP043612.1\|WP_111376995.1\|5106203_5106917_-\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|226584	COG4099, COG4099, Predicted peptidase [General function prediction only].	1.28993e-29
NZ_CP043612.1\|WP_111377010.1\|5130099_5130939_-\|conjugative-transposon-protein-TraN	gnl\|CDD\|163492	TIGR03780, Bac_Flav_CT_N, Bacteroides conjugative transposon TraN protein. Members of this family are the TraN protein encoded by transfer region genes of conjugative transposons of Bacteroides. The family is related to conjugative transfer proteins VirB9 and TrbG of Agrobacterium Ti plasmids. [Cellular processes, DNA transformation].	4.52074e-120
NZ_CP043612.1\|WP_111376996.1\|5106922_5108302_-\|beta-glucosidase	gnl\|CDD\|370812	pfam10091, Glycoamylase, Putative glucoamylase. The structure of UniProt:Q5LIB7 has an alpha/alpha toroid fold and is similar structurally to a number of glucoamylases. Most of these structural homologs are glucoamylases, involved in breaking down complex sugars (e.g. starch). The biologically relevant state is likely to be monomeric. The putative active site is located at the centre of the toroid with a well defined large cavity.	3.24639e-100
NZ_CP043612.1\|WP_111377003.1\|5121852_5122878_-\|ATP-binding-protein	gnl\|CDD\|377306	pfam04326, AlbA_2, Putative DNA-binding domain. This family belongs to the AlbA clan of DNA-binding domains.	1.87816e-07
NZ_CP043612.1\|WP_111377007.1\|5127413_5128295_+\|restriction-endonuclease	gnl\|CDD\|377369	pfam04471, Mrr_cat, Restriction endonuclease. Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA.	0.00470786
NZ_CP043612.1\|WP_111376999.1\|5115939_5117124_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP043612.1\|WP_111377092.1\|5113092_5115837_-\|histidine-kinase	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	0.00011065
NZ_CP043612.1\|WP_111377005.1\|5125582_5125954_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.08148e-13
NZ_CP043612.1\|WP_111377002.1\|5120833_5121436_+\|hypothetical-protein	gnl\|CDD\|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	0.00233275
NZ_CP043612.1\|WP_111376997.1\|5108377_5109835_-\|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl\|CDD\|185760	cd08977, SusD, starch binding outer membrane protein SusD. SusD-like proteins from Bacteroidetes, members of the human distal gut microbiota, are part of the starch utilization system (Sus). Sus is one of the large clusters of glycosyl hydrolases, called polysaccharide utilization loci (PULs), which play an important role in polysaccharide recognition and uptake, and it is needed for growth on amylose, amylopectin, pullulan, and maltooligosaccharides. SusD, together with SusC, a predicted beta-barrel porin, forms the minimum outer-membrane starch-binding complex. The adult human distal gut microbiota is essential for digestion of a large variety of dietary polysaccharides, for which humans lack the necessary glycosyl hydrolases.	2.61831e-50
NZ_CP043612.1\|WP_111376998.1\|5109839_5112848_-\|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl\|CDD\|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
NZ_CP043612.1\|WP_111376994.1\|5103809_5106110_-\|beta-glucosidase-BglX	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	0
NZ_CP043612.1\|WP_111377001.1\|5119577_5120651_-\|magnesium/cobalt-transporter-CorA	gnl\|CDD\|213362	cd12828, TmCorA-like_1, Thermotoga maritima CorA_like subfamily. This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	1.52807e-123
NZ_CP043612.1\|WP_111377000.1\|5117427_5119521_-\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0

>NZ_CP043612.1|WP_111377002.1|5120833_5121436_+|hypothetical-protein
MQKTENLESGKYYHIYNRGINGENLFKENRNHEYFLMLYTKHIDPIAETLAWCLLKNHFHILVRIKTFEEILESHKEYEIKKIIPIHQSFGNLFNAYTKAINKGYNRHGALFERPFKRKLINNQSYLCSVIKYIHYNPVNHGFCEHPIEYPWSSYLTCVSEKQTKLKREKVISLFENLDNLKSVHNKRENFTLLEEFLNL
>NZ_CP043612.1|WP_111377001.1|5119577_5120651_-|magnesium/cobalt-transporter-CorA
MRKIKYKKGRKLQHITLEYTGSHREHETEMQLFVYNDADVVEYDKFTVLALNSCFDYTKNNWLNIHGLHDINLIKTIGAHFKLDDFLLADILNTTKRTKLEDQQEILFFNIKSLLPSEYSDNISVEQLSFILKEGVLISFQEKRSDFFTHIRERLRTHAGIVRTKKVDYLLYLLLDAVMENFYITLEDEEDKIEDLINLTKKEAKPVILEKIENHRDNLNFLKRSIVPLRDSLYYLKTKKDDDDDNGLIQKETFNFFIRLHQKSLELLDQIESDMSALESASNFYFSEQSRKMNEIMKTLTIISAIFIPLTFIVGVYGMNFENMPELKTQNGYFIVMGIMLLLVIALIVYFKKRRWF
>NZ_CP043612.1|WP_111377000.1|5117427_5119521_-|phosphate-acetyltransferase
MSKAIYIATSDHNSGKSIITLGLMSILIGKTAKVGYFRPIIEDFVDGEVDNHIETVLSYFNLDIAFEDAYAITKSRLIKKKNKGKIGEVLDLIIEKYKKLEERFDFVLVEGTSFTGEGTSIELDLNVLIAKNLGIPTIIVGSGVGKTLEELLDSLYLVYDSFKLKEVEVLSVFANKVQPENIELVTNSLQKTLPSNVLINTIPLVSTLNNPTMQEIVNELNAKVLFGENYLNNEIGHYSVGAMQLHNYLVHLHNNALVITPGDRSDIILGALQANESANYPTISGIILTGNIVPEESILKLIEGLSAIVPIIAVDGGTYHITNKIGSIKSEIYANNTHKIETSINTFEKYVEIEALSQRVITFQPEGMTPKMFQYNMVKRAKQHRKHIVLPEGNDDRIITAASRLLDMDVVDISIIGDKKQIESKVAELGLTFDFSKVSIINPIESEMYEDYANTYYELRKAKNVSITMARDLMEDVSYFGTMMVYKGHADGMVSGAAHTTQHTILPALQFIKTKPNSSVVSSVFFMCLEDRVSVFGDCAINPNPTAEQLAEIAISSAESSLAFGIEPKIAMLSYSSGSSGKGDEVDKVRTATAIVKEKRPDLKIEGPIQYDAAVDLSVGKSKMPDSEVAGQASVLIFPDLNTGNNTYKAVQRETGALAIGPMLQGLNKPVNDLSRGCTVDDIINTVVITAIQAQGM
>NZ_CP043612.1|WP_111376999.1|5115939_5117124_-|acetate-kinase
MKILIINSGSSSIKYQLMVMPENEVICSGMIDRIGLETSNITFKTDTVSREETLPIPNHKVGLQKVANMLLDPEKGVIKSTSEIAAVGHRVVHGGSDFSATVKIDEKVKEKIKQLFELAPLHNPANLEGINVAEEIFSSAEQIAVFDTAFHQTMPEVAYKYAIPNYLLTENKVRVYGFHGTSHKYVSEKAINYLKDNSKIITIHLGNGCSMAAVKDGKCIDTSMGFSPSNGLIMGTRAGDIDQSVVFYMIKNLGYTPDEVNAVLLKQSGMLGLTGYSDLRDIEAEAEKGNKDCLLALQMNAYRIRKTIGAYAAALNGLDAIVFTAGIGENSSYMRNLICTDMDYFGIEIDTGKNELRSKELREINSEKFKVKVLVVPTDEEYEIANQVFQLLEN
>NZ_CP043612.1|WP_111377092.1|5113092_5115837_-|histidine-kinase
MKSILFKSVFFFFIALQLQAQELLPFVENYSKSDYQGDNQIWNVVQGNDNAMYFANNHYLLRYDGVKWEKYTLPNKTIIRSILIEGDKIYSGSYKEFGYWYRKDGTMHYVSITKNLRLFDEKDNEEIWKIFRFNGALYFQSFNDVFIYNGKSIKKIKFPFLISYCFGVDKNLYVASVKDGIYKMNGKYIANPKGWDVLKNTVVHAIEKFQNTTYIFTQKKGVFIVEKNGLRSWDHPINETLKAATINVAKFVKNDKLIIGTGNRGIYILDLKNNSYKNIERNNVLMNNSVLSIGLDKENDLWVGLDNGIAHVEVNSPISFFYDNSGLLGSVYAVAAINKGYLIASNHGIFEYSAGKFNMMPNTQGQGWNISLIDGKYIIGHNDGTFSYENNTLTKINGVSGGWNMSKSSINNTYFQSTYSGILVYDDPSNMSHYKIIKDLAKPIKYVAQNKKNEIWAADNYRGLYRVLLDDNYNTLKVENVTQQSKIQNDFGIKIFEFRKEILFLINNSWYTYNSISNKLEENELFNTNFRNVTDVVSIDEDHFMVLQNGILYHIYAQGNKFVWNIIQEKYYKGKLINENLRIFKKDNYYLFNLDDGFISLKLEYENKQNSEVKIEAFSNDALVPSEEKIKFNTELKINVISGIYGASKPNLFYKLDKEKEFIPISDGLIVLNNLSSGYHTVEIFKHDGATYDKVSSYKFKVAEPWYFSFWMILLYFLVIGAVLFFYYKWNKLRYMQKLKLQAEELKHQREILEMELKKENELNIQEYEKHILELELQAKSSEVAGKSLSIAKQTEMIDKIQGILESEKDFSKLKNEIRKAIKINEVNKHEWETFETNLNQIHNEFIINLSKKYPQLTPKDIKLCVYLKMNLSSKEIAPMMNISFRGVELHRYRLRKKLNLTQDENLSKFLLTL
>NZ_CP043612.1|WP_111376998.1|5109839_5112848_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKNFIFSFLALLLLPTFMLGQTQAIKGKVVDSSGMGIPGAIIASADARATADADFDGNFTINAKPGDILKISMLGFDSVSVPATAAPMTITLKEAGDTALKEVVVIGYGTRKKIDNTSAVSSIKSEEITKMKVMNASQAIQGKAAGVQVSTSDAPGSTPSVVIRGAGTALGGRNPLYVVDGMPTDNINNINTNDITSYEVLKDASSLAIYGTRGANGVIMITTKAGKGKITVDVESFAGVRSPLKTVKMANADEYVRYSNAAYSNVFPQGRFSANQPYNTDWLDAITRTGSYTQNNIAVSGSSENVKYFFSLGNYEEKGILNGSDYGRTTFRNNNEFKLSEKVKLTQNFSVSTIKNTPMPLSAFTNAYRQSPLVPVRYADGKYGVPFVLNGVVGETGESFNNVGNPVAQLDYTNEQQKSVTLQGGLKLDWDIIKSLKFTSQFNGEYYTYKQYNYVDNVALWLSADPTRTVEKYPLDLNKNTLTRSRDEYFNWNLSNYLTYNKVFAEIHDVEVTAGIEANVQGTREKLTIDRKNVNPNSNYWSLKDVNNVANVTGYKDEALNQRRLASYFARFQYKLMDKYLVTGTVRRDGSSQFNEDNRWGTFPSVGLGWIISKESFLSNVEPINLLKLRGSWGRLGNQNVPLNTQVFTSGVDYPDLGSGTTINSQVDPNLSWEIVEELSGGFDFEMFNSRLKGSFDLYDKNTTNTILNVKPYSTSGITLATPAHVGEVSNKGYEIALRWDDKINDNLSYWVGGNFSHNKNELTSLKNVQLNPIIGGSLGNGQNTKILDNTSVGQPLGSFYMYEYAGVDPTNGQMLYYKADGSKVPQTGLDELKDKKYVGTLLPTSTYGVTLGLTYKNIDFSVDGYGTGGAKVYNGKKAQRFGGENVEASMANGFWTPTNTTSSIPAPSNLTPYASTYYLESADFFRINNITLGYKLPIKENNFISYCRLYVNAINPFITQKFSGFSPDVVSDGKLVEGTQGVELDAYPSLRSFVVGANLKF
>NZ_CP043612.1|WP_111376997.1|5108377_5109835_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKRIYISMFVLSGLLFTGCSDDFLDVESTESIPADPALVNSDAGASSFVTAIYNQFLGWDMSSFGWNAVTSIISDDADKGSDPGDAGGDKDIMDALTYNASTPSFQSTWNANYAGINRCNQALAIFPKLDQVTPSLKVRLEGEAKFMRAFMYFTLVKGYGGVPIVDHLPIPGNDSDRIMQLTRKTPAEVYAFIEKDLTDAIANLPEKSAYTGKDVVRASKGAAYALLAKVNLYQKNWQKVIDNCDKVTGYSLVSDYSLQFKKEGEFGSESIFEIDGIGGTSSPGFGIGNYTVSQAPRGAGGWGWGFNTPTEGLANAYEAGDVRRAATIIFRGSVLYDGREVPSTVANARYNYKAYSSSFYNQEFTDTNLRYLRYAEVILMKAEALNELGQTSAAIPLVNQIRHRAGLGDTPFTSQTDIRKAIYKERRLEFAFEHDRWFDIVRTGQAEAAMAADGKTFIVGKHELWPLPTTFMREAGTLSQQNPGY
>NZ_CP043612.1|WP_111376996.1|5106922_5108302_-|beta-glucosidase
MIRISVLFLAFTFFSCGSNADKSKENVQENTSGVTALTDEQLLDAVQKQTFKYFWDYAEPNSGLARERYHPDGVYPENDSNIVTTGGSGFGLMALVSGMSQGYITKEQGVERLNKIADFLGKADRFHGAWSHWIDGNTGKVKPFGTKDNGGDLVETSFLVAGMITVREYLKDGSEKEKAVAQKYDALWKSVDWQWYTNNKNVLYWHWSPNYAWQMNFALEGYNECLITYVMAASSPTHTIDAKAYHEGWARSGGIVSSKTKYNIPLILKHNGAEEFGGPLFWAHYSYVGLDPNQLTDKYANYWDLNVNQTKINYEYCVQNPNKSAGYGPEYWGLTASYSRNPDGSIGYNAHMPSNDQGVISPTAAISSIVYTPKESVAVIRNLYENHKDETWGDAGFYDALSLGNKWVAKRYLAIDQGPEVVMIENYRTGLLWKLFMNAPEVKQGLTKLGFKSGKYGIQ
>NZ_CP043612.1|WP_111376995.1|5106203_5106917_-|prolyl-oligopeptidase-family-serine-peptidase
MKYKIAFLSFLFSLLGFSQSETTGKINTVIMEKYELGYVLHKPANTKEKKPLIVFISGDGEKGTDLEKVKINGPLKYLKTHQLDAYVLAPQCKEDENWDIESIYQLILKIQKENKIDSERIYVTGLSSGGWASWNLAFAHPDLFAANVPVAGFVDLIQLEKACEIANIPTRIFHGLLDDVVNVNYAITIYKELKKCNAKDVKLTIFDDAGHDSWTKVYDNQEIYDWMLQQRKTNTNK
>NZ_CP043612.1|WP_111376994.1|5103809_5106110_-|beta-glucosidase-BglX
MKNKLVLLFLGCAVLGYAQKKPAKNTVKIKPKSEFVAELMSKMTLDEKLGQLNLPTSGDITTGQANSSNVAKNIAEGKVGGLFNIKSVQKIKEVQKIAVEKSRLKIPLLFGMDVIHGYETTFPIPLGLSCTWDMGLIERSAQIAAKEASADGINWTFSPMVDISRDPRWGRVSEGSGEDPYLGSQIAKAMVNGYQQHDLTKNNSILACVKHFALYGAPEGGRDYNTVDMSHIRMFNDYFPPYKAAVDAGVGSVMASFNEVDGIPATGNKWLMTDVLRKQWGFKGFVVTDFTGIPEMIPHGMGDLQQVSALALNAGVEMDMVGEGFLGTLKKSLDEGKVKIETIDNAVKLILEAKYDLGLFQDPYKYCDEKRAKTEIFTTDSRKEARDIAAQSLVLLKNQNQLLPLKKSGTIGLIGPLADAKENMPGTWSVATKMENAVSLLRGIKEVAGTGTKVLYAKGSNLDYDETFETNATMFGKTLHRDARTKEELLAEALKVAEQSDVIVAALGESAEMSGESSSRTNLEIPQAQKDLLNALLKTGKPVVLVLFDGRPLVITDEEKTVPAILNAWFAGTEAGYAIADVLFGDVNPSGKLTSTFPRSVGQLPIYYAHKNTGRPLSNTEGKFEKFRSNYIDERNEPLFPFGFGLSYTTFDYSNLKISSDKMNPSGKLKVTVDVTNTGNFDGKETVQLYIRDLVGSVTRPVRELKGFQKIALKKGEKQTVNFDITVEDLKFYNSDLQFVAEPGQFDVFVGGNSNADKKVSFELTK
>NZ_CP043612.1|WP_111377003.1|5121852_5122878_-|ATP-binding-protein
MHKVIEIIKYESESHKADFKKIEYPLGKDIKKNEILKDFSAFANHLSDEEKYIIIGIKENADKSKSVFSVDTPTDESKYRQFINENIEPEINFEYETISYQDAIICFFRLSQNFNRPYLFKKDVKNPITDKPEFKYGDGYIKTGSSTKKIGRKELDDIIENKNNSTNRQEDINILKIFGSPSNIEISKWELSFLDIKIENRSNKSIDLDVEIVIKKSDSFALILEEELLREIKRQESKKTNSVYFPPIASANFIMNNLHLNKEENETEFIVQRNPLKSKFALTLAQNSISENIFQEAIIVLDKQSSIIDAKVIIRSDDFTKGALTKNIRYITPERTVNSSK
>NZ_CP043612.1|WP_149229165.1|5122995_5123379_-|hypothetical-protein
MQHLEHEFLQEYKEIKPQDRKSLQAMAEREAEFFDFLNPARDFFNSQKSIFIQHYLKDILSLYEYFLQVKAESRIIFLEEKKTALFAILLQIYELEVKMLYRWYSDEIDELMALKKIDIDLLNWLRN
>NZ_CP043612.1|WP_149229166.1|5123441_5124440_-|hypothetical-protein
MKINRIIAIAVNEYDNVELNKIENAKRDVSEIISVLNEKYIFEDVEFLFDKTDTTRKSIFNKLNLIFTNALEDENILLIYAGHGEYNDVLKTSYWQPSDCDPQDISTWINIGEIMAFINASQAFHIAIISDSCFSGAIFENPNRGGGVQAFEKRKSRLALTSGGVEMVSDGAKGHNSPFAENLIKHLSENGQATLPFSVLSNNLIISFNLDRVQTPMFGALNNVGHEGGSFIFKLKGLETEKHENTNDYLKLRLGNLFIKVADEHRSLISKITLINKEKHELVRIQKYEQAMKLRDEEKRIEDLIHDSTPSYINQMFLKVEVSKRQTEIIKK
>NZ_CP043612.1|WP_111377005.1|5125582_5125954_+|helix-turn-helix-transcriptional-regulator
MTTSKNYLIQSKSDTPLNFSNKTNTMNLGSVIKDIRKQKGQTQTEFASSCGITQTYLSQIENNTKEPNLSTLKEISSKLDIPLPILFFMSLNDDDIAPEKRKAFEIINPSVKSLINEFFRVSK
>NZ_CP043612.1|WP_111377006.1|5125928_5126783_+|RNA-directed-DNA-polymerase
MNSSESRNNLHFPSIIGESKNDLDNIIRNIDSHYNEWIEEKIDKKTGQFKTYLDGTIKKRVIRPSKKRLKGIQSKIKDRILSKIELPDNVHGGVKKKSNITNAKQHQGNKYQFATDLKDFYPSIKSKIIHDTFVKLGYNKQFAFYMTKLTTWKGELPQGTPTSTHLSNIIFLETDYKLIKICNENNITYTRYIDDLTFSSQKDIQEFIPVFLNIIKDSGVKISHRKTEYKGNQNITGINIFLNKIDAPEKIILKAEEENIAEKKIKPYNSYLSNIRKTNKRKKN
>NZ_CP043612.1|WP_111377007.1|5127413_5128295_+|restriction-endonuclease
MEYLSYEIKDQIIQCFGKCFHYKDNVESFLRSAGVSRELAQKYKDEAKYVWARKVLNDLENFEDGKIIQRKILGELCLLRNVPAEVPDRNAGIEALRRLKSLVAEKQLQFEEQKTHTKSRAQQMKDKTQIILERNNKLLELKSLFFKGLIADDRQKAGYELEHILKALFAISELEYKKPYKTETQQIDGHFKFDGFNYLVEAKWRKDMPNENEIGGFQRKVNTKLDSTRGLFVSVNGYREEVISQFNGQGANIILMNGEDLMHILEGRIELKEALQIKVDKASQYGIVYTRIL
>NZ_CP043612.1|WP_111377008.1|5128625_5128922_-|hypothetical-protein
MENLKPLSDFFAAIEKDFRISTTHIAIYAALLQLRIGKGFINPVEVFSRDIVSIAKISSTYTYIKCVQDLNDYGYINYVRSFKKTQASKIYFVDLQGS
>NZ_CP043612.1|WP_111377009.1|5128927_5130067_-|hypothetical-protein
MTIDLSDSEMMLSFTQEMASLGYQYVAFDIEIVNNSNTLEFYRNILDAQEYCSVMTNDAGYFENLPVKSLINDLEALVNSGIDITCKEAIEITGFANRREKSELLDNNLNSNIMNQKNLEYLKDQLKYTGFGETFDLDLKEKMMQGEKEFKISREGVYGSDSMNAVLNFKKSDQTDMYFFNSYHVSLQKENSKESLDQTFYINSTGGNITLKEAYNLMEGRSVNKDLKNKDGELYNSWIKIDFKQTDEAGNFKLNHYHQNYGYDLEASVAKHSIKELDTPKFKEDLLNSLKKGNLQSVTFVVGGVESKMFIEANPQFKTVKVYDENMQRINHRESKEEKKSILENQSASKDQKKSSDGDSDSSEPEKKNNNRKSKSHSI
>NZ_CP043612.1|WP_111377010.1|5130099_5130939_-|conjugative-transposon-protein-TraN
MKKYNLIYLISFCFLAISSFAQLNNRKTNSNADNLVNLNIGYSKTTSLVFPYAIKSIDKGSPDIIMQKAKGVENILLLKANRQNFAQTNLTIVTADSRLYVFVLNYNDDCPDLNVNADNLAVVNDDILFSKENENQKKIEQFAALALAKKKKITGIQRSKFDIKLSVSGIFIHEDVMYFRLVIDNNSKINYELDQLRFFIRDKKKAKRTASQEIEIIPLYDSNSRNVIAAKSEWTAVYAMPKVIIPEKKYLTIQLIEKNGQRQLEVDINNNLTKKISAI
>NZ_CP043612.1|WP_111377011.1|5130955_5132245_-|conjugative-transposon-protein-TraM
METKTLSIKEVKKRKMLLVLPLITLPFITLLFYVLGGGRTEAAVSSYEQKKGFNFKLPMPKFKEDSALDKMSYYDQAATDSLKLLEQIKKDPNYSKSTISNGLEDEFAAEDFEKHLFSKENKGFNSAPLEQGKEEKVYEKIKALQKIISQPVTADSYGQDMSEFESYGRSKESSQGIKNLEKMMASMGTVQEPDPELQQLGGMLENILDIQHPQRVQERLKQSSESKKGKVFTVDPNIEIDISTSLQKTSSIIDNSKGNSFYSVDESAELDSQPNAIQAVIHETQIIVNGSIVKLRLSNDINLQGTVIPKNTFLYGTASLKGERLEVKVDNIQFRNSIFPVELTIYDLDGISGIYIPGAINRDVAKASAERSIQTLGLTGISDSWGAQAAGMGVEAAKSLISKKVKLIKVVLKAGYQVLLYDEKQKNLK

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Crispr_ID: NZ_CP043612_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP043612_11

5451095-5451189

Orphan

Consensus_repeat	Method
ATATTCCTATCGGAATATTAAAAAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP043612_11

>merge|NZ_CP043612|11|5451095-5451189|CRISPRCasFinder
ATATTCCTATCGGAATATTAAAAATTGTTTATGCCTATAATTTTGCCGTTTCTTTACTTCTACCAATGAAATATTCCTAACGGAATATTAAAAAT

>NZ_CP043612|11|10|5451095-5451189|CRISPRCasFinder
ATATTCCTATCGGAATATTAAAAAT	TGTTTATGCCTATAATTTTGCCGTTTCTTTACTTCTACCAATGAA
ATATTCCTAACGGAATATTAAAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP043612.1\|WP_111378630.1\|5439417_5440863_+\|nitrite-reductase,-copper-containing	unknown	unknown	gnl\|CDD\|131429
NZ_CP043612.1\|WP_111378637.1\|5447887_5448334_-\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242
NZ_CP043612.1\|WP_111378633.1\|5442781_5443987_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378648.1\|5459804_5460866_+\|DUF3810-domain-containing-protein	unknown	unknown	gnl\|CDD\|378933
NZ_CP043612.1\|WP_111378645.1\|5456852_5457635_+\|carboxypeptidase-like-regulatory-domain-containing-protein	unknown	unknown	gnl\|CDD\|372685
NZ_CP043612.1\|WP_111378646.1\|5457727_5458066_+\|DHCW-motif-cupin-fold-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378635.1\|5445006_5447241_-\|nitric-oxide-reductase-large-subunit	unknown	unknown	gnl\|CDD\|225795
NZ_CP043612.1\|WP_111378634.1\|5444249_5444981_-\|iron-sulfur-cluster-repair-di-iron-protein	unknown	unknown	gnl\|CDD\|274701
NZ_CP043612.1\|WP_111378632.1\|5441673_5442270_+\|SCO-family-protein	unknown	unknown	gnl\|CDD\|239266
NZ_CP043612.1\|WP_111378647.1\|5458137_5459598_-\|aminoacyl-histidine-dipeptidase	unknown	unknown	gnl\|CDD\|349885
NZ_CP043612.1\|WP_111378639.1\|5449349_5450864_+\|FMN-binding-glutamate-synthase-family-protein	unknown	unknown	gnl\|CDD\|239202
NZ_CP043612.1\|WP_111378641.1\|5451895_5452303_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378642.1\|5452310_5453489_-\|glucuronyl-hydrolase	unknown	unknown	gnl\|CDD\|369381
NZ_CP043612.1\|WP_111378644.1\|5454759_5456679_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP043612.1\|WP_111378715.1\|5453607_5454003_+\|DUF2809-domain-containing-protein	unknown	unknown	gnl\|CDD\|378530
NZ_CP043612.1\|WP_111378638.1\|5448534_5449314_+\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350237
NZ_CP043612.1\|WP_111378636.1\|5447339_5447867_-\|azurin	unknown	unknown	gnl\|CDD\|259989
NZ_CP043612.1\|WP_111378640.1\|5451197_5451629_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP043612.1\|WP_111378631.1\|5440879_5441656_+\|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl\|CDD\|224182
NZ_CP043612.1\|WP_111378643.1\|5453977_5454556_+\|non-canonical-purine-NTP-diphosphatase	unknown	unknown	gnl\|CDD\|237823

Protein	Function_ID	Function_description	E-value
NZ_CP043612.1\|WP_111378630.1\|5439417_5440863_+\|nitrite-reductase,-copper-containing	gnl\|CDD\|131429	TIGR02376, Copper-containing_nitrite_reductase, nitrite reductase, copper-containing. This family consists of copper-type nitrite reductase. It reduces nitrite to nitric oxide, the first step in denitrification. [Central intermediary metabolism, Nitrogen metabolism].	1.39123e-119
NZ_CP043612.1\|WP_111378637.1\|5447887_5448334_-\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	1.19461e-23
NZ_CP043612.1\|WP_111378647.1\|5458137_5459598_-\|aminoacyl-histidine-dipeptidase	gnl\|CDD\|349885	cd03890, M20_pepD, M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide. Peptidase M20 family, Peptidase D (PepD, Xaa-His dipeptidase; X-His dipeptidase; aminoacylhistidine dipeptidase; dipeptidase D; Beta-alanyl-histidine dipeptidase; pepD g.p. (Escherichia coli); EC 3.4.13.3) subfamily. PepD is a cytoplasmic enzyme family characterized by its unusual specificity for the dipeptides beta-alanyl-L-histidine (L-carnosine or beta-Ala-His) and gamma-aminobutyryl histidine (L-homocarnosine or gamma-amino-butyl-His). Homocarnosine has been suggested as a precursor for the neurotransmitter gamma-aminobutyric acid (GABA), acting as a GABA reservoir, and may mediate anti-seizure effects of GABAergic therapies. It has also been reported that glucose metabolism could be influenced by L-carnosine. PepD also includes a lid domain that forms a homodimer; however, the physiological function of this extra domain remains unclear.	0
NZ_CP043612.1\|WP_111378648.1\|5459804_5460866_+\|DUF3810-domain-containing-protein	gnl\|CDD\|378933	pfam12725, DUF3810, Protein of unknown function (DUF3810). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 333 and 377 amino acids in length. There is a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterized family of peptidase enzymes.	7.70517e-119
NZ_CP043612.1\|WP_111378645.1\|5456852_5457635_+\|carboxypeptidase-like-regulatory-domain-containing-protein	gnl\|CDD\|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	9.35992e-17
NZ_CP043612.1\|WP_111378635.1\|5445006_5447241_-\|nitric-oxide-reductase-large-subunit	gnl\|CDD\|225795	COG3256, NorB, Nitric oxide reductase large subunit [Inorganic ion transport and metabolism].	0
NZ_CP043612.1\|WP_111378634.1\|5444249_5444981_-\|iron-sulfur-cluster-repair-di-iron-protein	gnl\|CDD\|274701	TIGR03652, FeS_repair_RIC, iron-sulfur cluster repair di-iron protein. Members of this protein family, designated variously as YftE, NorA, DrnN, and NipC, are di-iron proteins involved in the repair of iron-sulfur clusters. Previously assigned names reflect pleiotropic effects of damage from NO or other oxidative stress when this protein is mutated. The suggested name now is RIC, for Repair of Iron Centers. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	5.22714e-87
NZ_CP043612.1\|WP_111378632.1\|5441673_5442270_+\|SCO-family-protein	gnl\|CDD\|239266	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c oxidase (COX). They contain a metal binding motif, typically CXXXC, which is located in a flexible loop. COX, the terminal enzyme in the respiratory chain, is imbedded in the inner mitochondrial membrane of all eukaryotes and in the plasma membrane of some prokaryotes. It is composed of two subunits, COX I and COX II. It has been proposed that Sco1 specifically delivers copper to the CuA site, a dinuclear copper center, of the COX II subunit. Mutations in human Sco1 and Sco2 cause fatal infantile hepatoencephalomyopathy and cardioencephalomyopathy, respectively. Both disorders are associated with severe COX deficiency in affected tissues. More recently, it has been argued that the redox sensitivity of the copper binding properties of Sco1 implies that it participates in signaling events rather than functioning as a chaperone that transfers copper to COX II.	1.53317e-35
NZ_CP043612.1\|WP_111378639.1\|5449349_5450864_+\|FMN-binding-glutamate-synthase-family-protein	gnl\|CDD\|239202	cd02808, GltS_FMN, Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast and bacterial pathway for ammonia assimilation. It is a multifunctional enzyme that functions through three distinct active centers, carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.	1.61609e-173
NZ_CP043612.1\|WP_111378715.1\|5453607_5454003_+\|DUF2809-domain-containing-protein	gnl\|CDD\|378530	pfam10990, DUF2809, Protein of unknown function (DUF2809). Some members in this family of proteins are annotated as yjgA however currently no function for the protein is known.	7.07581e-26
NZ_CP043612.1\|WP_111378642.1\|5452310_5453489_-\|glucuronyl-hydrolase	gnl\|CDD\|369381	pfam07470, Glyco_hydro_88, Glycosyl Hydrolase Family 88. Unsaturated glucuronyl hydrolase catalyzes the hydrolytic release of unsaturated glucuronic acids from oligosaccharides (EC:3.2.1.-) produced by the reactions of polysaccharide lyases.	6.17643e-17
NZ_CP043612.1\|WP_111378644.1\|5454759_5456679_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.8901e-142
NZ_CP043612.1\|WP_111378638.1\|5448534_5449314_+\|NYN-domain-containing-protein	gnl\|CDD\|350237	cd11297, PIN_LabA-like_N_1, uncharacterized subfamily of N-terminal LabA-like PIN domains. This N-terminal LabA-like PIN domain is found in a well conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. LabA from Synechococcus elongatus PCC 7942, (which does not contain this C-terminal domain), has been shown to play a role in cyanobacterial circadian timing. The LabA-like C-terminal domains characteristic of this subfamily may be related to the LOTUS domain family (which also co-occurs with LabA-like N-terminal domains). The function of the N-terminal domain is unknown. The LabA-like PIN domain family also includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Other members are the LabA-like PIN domains of human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	4.40772e-65
NZ_CP043612.1\|WP_111378636.1\|5447339_5447867_-\|azurin	gnl\|CDD\|259989	cd13922, Azurin, Azurin is a redox partner for enzymes such as nitrite reductase or arsenite oxidase. Azurin is a bacterial blue copper-binding protein. It serves as a redox partner to enzymes such as nitrite reductase or arsenite oxidase. The copper of Azurin is tetrahedrally coordinated by a cysteine, 2 histidines, and a methionine residue. The electron transfer reactions are carried out with the Cu center transitioning between the oxidized Cu(II) form and the reduced Cu(I) form. Azurin can function as a tumor suppressor; it forms a complex with p53 that triggers apoptosis in various human cancer cells.	8.44246e-59
NZ_CP043612.1\|WP_111378631.1\|5440879_5441656_+\|formylglycine-generating-enzyme-family-protein	gnl\|CDD\|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	5.06495e-37
NZ_CP043612.1\|WP_111378643.1\|5453977_5454556_+\|non-canonical-purine-NTP-diphosphatase	gnl\|CDD\|237823	PRK14823, PRK14823, putative deoxyribonucleoside-triphosphatase; Provisional.	1.67983e-122

>NZ_CP043612.1|WP_111378639.1|5449349_5450864_+|FMN-binding-glutamate-synthase-family-protein
MRKKFFIYGFLLFIIVAAIYYYTGRGYLLVFIIPLLLIVGAYNASQEKHAILRNFPVLGYFRYLFEMIAPEIQQYFIERSTDGKPFSRNQRSLVYQRAKNIDSSTPFGTQLNLNTENYEGIKHSIFPAKVNEELPRVLVGGKDCKQPYSASLFNVSAMSFGSLSEHAVRAINIGAQKGNFYQNTGEGGLTEFHLAGGGDITWQIGTGYFGCRDAEGNFSPENFSEKANLPNVKMIEIKISQGAKPGHGGVLPARKNTEQIAKIRGVVPHTMILSPPGHHAFSDPNGLIQFIKQLRDLSNGKPIGFKLCIGNTAEFEAICQEMINEDTYPDFITVDGAEGGTGAAPLEFADGVGMPFEPALIFVNKTLVRLGIRDKMRIIGSGKIISGYSILHAIALGADMCNSARGFMFSLGCIQALRCHNNECPTGVATQNKMLMKGLVVTDKSERVYHFHKNTLHAANELLAAAGKTSFADVDINIFMRGDEFTNLSELYFPDNLKNVTQFS
>NZ_CP043612.1|WP_111378638.1|5448534_5449314_+|NYN-domain-containing-protein
MPLSNSKDLKLAVLIDADNVPYSNVKGMMEEIAKLGTPTTKRIYADWTKPNANGWKGVLLEHAITPIQQYSYTVGKNSSDSALIIDAMDLLYSGKLDGFCIVSSDSDFTRLAVRLRESGMKVIGIGEKKTPNSFIVACDRFIYIEVLDGATQKKKPKAVAADTKKTVEKPAEKALHKIDKQTIELIEATIEDIEDDDGWAFLGDVGNLIVKKKPEFDPRNYGYSKLTPMLKSLTDILEIDERESDKKGIKHVYVRLRFN
>NZ_CP043612.1|WP_111378637.1|5447887_5448334_-|Rrf2-family-transcriptional-regulator
MFSKACEYGIRASIFIATKSSKGIRVGIKDVAKEIDSPEPFTAKIMQILTKSGIIHSTKGVGGGFEVSPEASKSIKLIQIVDAIDGNKIYSGCGIGLKECSEEHPCPVHHEFKKIRGLLLEMLINTTLEQLASDVKSGDFFLKTNANN
>NZ_CP043612.1|WP_111378636.1|5447339_5447867_-|azurin
MNTKTKISVLILMGFLAVTSCGKKETAPADQTETTEPSTEGEQAPVAAATEENVLVIEGNDQMQFSVNELKAVAGKPIKLTLKHVGKIPKEAMGHNLVILQEGTDQAAFALKANDAKATDYIPESEKASIIAHTKLIGGGEEDTIEFTIDKKGSYPFICSFPGHVAMMKGVLIVE
>NZ_CP043612.1|WP_111378635.1|5445006_5447241_-|nitric-oxide-reductase-large-subunit
MKREKKLWIVFALVMSISFAVLGYYGYEIYQQAPPVPKEIVTDSGKAVFSESEIKDGQNIWQSIGGQEVGSIWGHGAYVAPDWTADWLHREAVFILDIYAQKDFNKKYEELDAEKQSALKVRLQKDLRTNRYNADTGTLTISENRLAAIEHLSEYYKGLFTNDPKFDKLREEYAIPKNSITDVERMHKMNAFFFWATWATVTNRPNGDISYTHNWPSDELVGNKATTELLAWSGVSIILLILSVGILVFYHAKSGEEEEFPLPKEDPLIKQGKTKSMGLVTKYFWIVSLLMVLQMVFGIITAHYGVEGNGLYGIPIDKILPYAVTRTWHTQLAIFWIATAWLATGLYIAPAVSGKDPKFQCFGVNFLFIALLIIVLGSMAGQWFGVMQKLNLVQNFWFGHQGYEYVDLGRFWQIFLLVGLFLWLALMIRPLLPVLKKKTEEKNLIILFLVSCTAIAMFYGAGLMWGRQTNLAIAEYWRWWVVHLWVEGFFEVFATVVIAFLFVRLGLLKTKTATLNVLFATIIFMSGGILGTFHHLYFSGTPTAIMALGATFSALEVVPLTLIGFEAYQNYKISKSTQWIADYKWPIYFMISVAFWNFLGAGIFGFIINPPIALYYVQGLNTTPLHGHTALFGVYGMLGIGLVLFVLRSLYRNVSWNNKLLKITFWSLNIGLFLMAILSLLPIGVWQAIESISHGMWYARSSELMQQPAMITLKWLRAIGDSIFGIGFITMAWFVFELTLKNKK
>NZ_CP043612.1|WP_111378634.1|5444249_5444981_-|iron-sulfur-cluster-repair-di-iron-protein
MENLKNKTIGSFVAEDFRTATVFSKYRIDFCCKGNRTVTEVCEKQNIDADALLENVLQVVQSENNGSIDFNSWPLDLLADYIEKTHHRYVEEKTNVLLPFLDKLCKVHGANHPELFKINELFIGCAGELSQHMKKEELVLFPFVKRMVKTKDTDGVLHQPSFGTVANPIAMMMHEHDNEGERFREIAALTDNYTPPADACTTYRVTFAMLKEFEADLHKHIHLENNILFPKAVILEKDFVEVE
>NZ_CP043612.1|WP_111378633.1|5442781_5443987_-|hypothetical-protein
MNSQKSWILCCFFNFLIACVFGLLMRFMYLFPLDLLNYSFLLHAHSHVAMLGWVYMIVYVLVVHFFIPKEKSQKPIYNRLFWLTEFSVIGMMIAFPIQGYALFSIVFSTLHILLSYVFCRLVWKDSLRDKSPSQRLLLVSILFMILSTFGVWCLGPAVSTLGKQSAFYQIAIQFFLHFQFNGWFILAILALFLKQFQNKIDEVKFKKFYFLMVVSTLLTVCFPVRWFIENDILSYINGLGVLMQLGAFFYFYKMLKPQIHHFKSTLDKITKMVYGLALCSLFLKVGIQLLTLFPNLAEVSHQIRNFVIGFIHLTTLGIITGFLFGIMLQNKMLSANSSSLKIGVKSFILGYIATEVLLFLQGWFFFFGEGSIPAYFQSILIFSILLVLGLVLMMSSIIKRK
>NZ_CP043612.1|WP_111378632.1|5441673_5442270_+|SCO-family-protein
MKKIAIAFLLLFSFYSCQEADKKESKAETKKEISDLSIYNLPSKWTTQDGKDIELKSLRGNVLVMVMIYTSCKAACPRLVADMRDIESKLEKKTKQHVKLILVSIDPNTDTPERLKSFAIENKMNQDPWIFLRSSEENTREFAAVLAVNYKKISPIDFSHSNIISVFNPEGELVFQQEGLGVNNEKTIETINLEAGKI
>NZ_CP043612.1|WP_111378631.1|5440879_5441656_+|formylglycine-generating-enzyme-family-protein
MKKYIFILTIFFSVFSVMKAQEKEMAFIKEGSYVPLYGAVSQKPVVVKSFYIDIYPVTNSEYLEFVKKNPSYQKSKIKGIFADKSYLSYWKNDFDFGSAKPKSPVTSVSWFAAKKYCECQGKRLATMDEWEYVAMADTKKIDARTKKEFNEYILSWYEKSRTYENEIGKTFKNYWGVYDMHGLVWEWTSDFNSIFLSGESRKDKSTDKNLFCGSGSVNASDLMDYAAFMRYAFRGSLKAQYSTRNLGFRCASTTKPKI
>NZ_CP043612.1|WP_111378630.1|5439417_5440863_+|nitrite-reductase,-copper-containing
MKRTNKTWIKTSFLMCSLFMLLILGSCKKEEAKDYADIMTEGEMDAELTSPPHVPKPVGNRTAMKLKLNMEIKEQEGTMTDGVKYTYWTFGGSVPGSFIRTRVGDEVEFHLKNHPDNKLPHNIDLHAVTGPGGGATSSLVAPGHEKVFSFKVINPGLYVYHCATAPVGMHIANGMYGLILVEPEGGLPPVDKEYYVMQGDFYTQGEYGAKGLQPFDMNKAVKETPDYVVFNGKVGALTNGGELTAKVGETVRLFVGNGGPNLVSSFHVIGEIFDSVHIEGGSTINKNVQTTLIPAGGAAIVDFKVETPGTFILVDHSIFRAFNKGALGMLKVEGKENKNIYSGTIQEGIYLPEGGTIQKMPGESTAKTAIPKRTVAEKINIGKEIFGTTCFACHQSEGQGIPSTFPPLAKSDYLNADSKRAIKTILHGLTGEVTVNGKKYNNVMPAQNLSDDEIANVLTYIYNSWGNNKTEVTPEMVKALR
>NZ_CP043612.1|WP_111378640.1|5451197_5451629_-|hypothetical-protein
MKKITQIAFVLAFALFLISCKNTKQKIQEHVSNYNNSVSIKGSGITSTAAKAFLNDNKIEIRIETNLEENDANKLAYKESFPDLLKEMIKNDQISSSLIAEGVKFDVYFLAYNNAILAQELVDQEELAVLEGTAKEGKETAKL
>NZ_CP043612.1|WP_111378641.1|5451895_5452303_-|hypothetical-protein
MLKRISQIAFAIIVVLTVVSCKNTKQKLQEYVVTYNKNIAPSFRAENVKLTTARGYINDDKIELRFETDLEQNEVNKSASVISFPKLIKLMIDKDEIPRQLIEEGVQFDVYFLADDNTVLDKETLTGESLKDFLK
>NZ_CP043612.1|WP_111378642.1|5452310_5453489_-|glucuronyl-hydrolase
MKAKFFTLIAALFLLGNQGYSQKNNSFNIKKQLDYCAEQASKTLKVIPNDGTSPRTVPNGSNEWKFVGYKDWTSGFWPGELWFLYEATKDKKWEKEADKFSRFLTPLSTSKAGDHDLGFQVFNSFGNGYRLTKNPEYKQIILRTADTLATLFNPKVGTIQSWPHNKMGGHNTIIDNMMNLELLFWASKNGGSKKLYDIAVKHAETTMANHFRPDNTSYHVIIYDYETGKKIKGRTAQGYSDDSMWARGQAWAIYGFTMTYRETKDAKFLDFAHKVARVYLDKLTTEDLIPYWDFNAPNIPNEPRDASAAAIVSSALLELSSYTKDKNLKAEYLTKAKKMIVSLSDNYQSHDVNSAFLLHSTGHKPANSEVDCSINYADYYYLEALLRLQKLK
>NZ_CP043612.1|WP_111378715.1|5453607_5454003_+|DUF2809-domain-containing-protein
MNKSRIYYFLVFLCIIFGGILSRKISFIPLWIGDFLYAAMIYFLVRVFFPSKKFFFIILLSLFICYCIEFLQLYQSEWIVDLRKTLLGKYVLGQGFLWSDILAYTFGIAIAFITEKSFLKHYNHESSFRIK
>NZ_CP043612.1|WP_111378643.1|5453977_5454556_+|non-canonical-purine-NTP-diphosphatase
MNLVFASNNKNKIAEIQSMLPESIKILSLEDINCLEDIPETADTIEGNAILKADYVTEKYGYDCFADDTGLEVNALNGEPGVYSARYAGEQKNADDNMDKLLEALKNEENRSAQFKTVITLNLNGKQYLFTGIAKGEITLTKTGTNGFGYDPIFKPENFTETFAELPLETKNEIGHRGKAVKQLIDFLSTTK
>NZ_CP043612.1|WP_111378644.1|5454759_5456679_+|DEAD/DEAH-box-helicase
MNKFEQLGLNESLLKAILDLGFENPSEVQEKAIPLLLEKDTDMVALAQTGTGKTAAFGFPLIQKIDADNRNTQALVLSPTRELCLQITNELKNYSKYEKGINVVAVYGGASITEQAREIKRGAQIIVATPGRMQDMINRGLVNIKNIDYCVLDEADEMLNMGFYDDIVSILSDTPDEKSTWLFSATMPQEVARIAKQFMSEPVEITVGAKNSGSSTVSHEFYLVNARDRYEALKRLADANPDIFSVVFCRTKRDTQAIAEKLIEDGYSAAALHGDLSQAQRDGVMKSFRGRQIQMLVATDVAARGIDVDNVTHVVNYQLPDEIETYNHRSGRTGRAGKLGTSIVIVTKSELRKISSIERIIKQKFEEKTIPSGIEICEIQLLHLANKIKDTEVDHEIDNYLPAINNVLEDLSKEELIKKMVSVEFNRFITYYKKNRDISVGGGERRERGDSEPREFSNNGAVRYFVNIGSRDNFDWMSLKDYLKETLDLGRDDIFKVDVKEGFSFFNTDPQHTDKVMDVLNNVQLEGRRINVEISKNDGGGRRDHNNRGGGRRDSGRREGNFAPRREGGFRSDRGSSRDGGSREGGSRDGGFRSDRNSSSRREGGFRSSAPRNEGGSDRAPRRSENFGDSSRPRRSRRD
>NZ_CP043612.1|WP_111378645.1|5456852_5457635_+|carboxypeptidase-like-regulatory-domain-containing-protein
MKYFAIFFFTLLANIGFAQDTQDAQPTVPQRVSGYVINDDSKQPLAGVNIINTNKVRGAKSDEKGYFEIDVQVNDTLHFSILGFQSLRIRVTNDWIKNKVTRIQLTEKAIALEEVVIAPFSLTGYLEIDSKLIPTKENYRYSISGLTQGYEAGEYAPNAFGKVLGSIFNPADMLYNFFGKNGKELKKLKEMKKDDTVRTLLESKYDRETVAVLLGISKDEIPEIMHRCNYSDSFIQTANDLQIMDAISACYEQYKVLKRN
>NZ_CP043612.1|WP_111378646.1|5457727_5458066_+|DHCW-motif-cupin-fold-protein
MSTIPFQTIDWSQIEKTEHIGETGTAYWQTIQLGGLRVRKVVYSKNYLADHWCQKGHIVHCLKGDFISELDNGEKMTLTKGMTYIVSDDMSSHRSITTKGVELLIIDGDFLV
>NZ_CP043612.1|WP_111378647.1|5458137_5459598_-|aminoacyl-histidine-dipeptidase
MSQEIRNLEPKALWNKFADLNAVPRPSKKEERVIEFMKNFGNSLGLETFEDEIRNVIIRKPATPGMENRKPIVMQGHLDMVHQKNADTVFDFDTQGIDMYVDGDWVRARGTTLGADNGLGVATIMAILESKDIPHPAIEALFTIDEETGMTGALNLKGGILQGQILLNLDTEEDDEIDIGCAGGIDVTATRTYHEEEVPEGSVGYTITVKGLNGGHSGMDINKGLGNANKIMNRLLFDAFENFGLQIVEINGGSLRNAIPRESVAKVIISQMFDEAYVYDMQEIISDIKAEYKTTEPNLSIEIVKGDLPEKVMELGVQEGIIRAIYAAQNGVYKMSADMVDLVETSNNIARVVIKDGEILVGCLTRSSVESSKFDLANSLRSAFELVGCEVELSGSYPGWTPNVNSEILEVLKEIYEKQNGEQPKVVACHAGLECGILGTNYPDMDMISFGPTIHGAHSPDERASISSAQKYWRFVLEILSNIPVK
>NZ_CP043612.1|WP_111378648.1|5459804_5460866_+|DUF3810-domain-containing-protein
MKSKYVLPLFLIVQIIFYKILPYFPDFVEGFYSKNLFVRISHFSRTLLGKVPFSVGDIIYALLLISIISWFWKIRKTWRTDWKDHLLTMLGKISVFYFFFHLLWAFNYYRKPLFEKMEIKREYTDADLLNFTKRLIAKTNEVQLQITKNDSAKVVFPYSQKESFQLILNGYDNLAKEHPYFKYETLSVKNSLFSVPLTYMGFGGYLNPFTNEAQINYLLPMHNFPLTTSHEMAHQIGFASESECNFIGLLASVKNDNLYYQYSGYSFTLSYCLGIWKYKNEKIFNQLKKTVHVGILKNFQESHDFWKKYDTFIDKGFHFLWDNFLKTNNQKDGMESYSKFIDLTINYYKTREL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP043612_2	2.1\|1170788\|24\|NZ_CP043612\|CRISPRCasFinder	1170788-1170811	24	NZ_CP013927	Alteromonas stellipolaris strain LMG 21861 plasmid pASTE61-200, complete sequence	119270-119293	2	0.917
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	MN855801	Bacteriophage sp. isolate 103, complete genome	3835-3859	3	0.88
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	MK250021	Prevotella phage Lak-B2, complete genome	314344-314368	4	0.84
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	MK250024	Prevotella phage Lak-B5, complete genome	308366-308390	4	0.84
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	MK250028	Prevotella phage Lak-B9, complete genome	313256-313280	4	0.84
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	MK250025	Prevotella phage Lak-B6, complete genome	311558-311582	4	0.84
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	MK250022	Prevotella phage Lak-B3, complete genome	311573-311597	4	0.84
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	MK250020	Prevotella phage Lak-B1, complete genome	313239-313263	4	0.84
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	NZ_CP014200	Escherichia coli strain MRE600 plasmid pMRE600-2, complete sequence	28256-28280	5	0.8
NZ_CP043612_1	1.1\|737726\|25\|NZ_CP043612\|CRISPRCasFinder	737726-737750	25	NZ_CP042885	Escherichia coli O10:H32 strain NMBU-W12E19 plasmid pNMBU-W12E19_01, complete sequence	85082-85106	5	0.8
NZ_CP043612_8	8.2\|3489636\|27\|NZ_CP043612\|CRISPRCasFinder	3489636-3489662	27	MG543995	Staphylococcus phage UPMK_1, partial genome	115381-115407	5	0.815
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	1878-1907	5	0.833
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP014857	Lysinibacillus sphaericus III(3)7 plasmid, complete sequence	159596-159625	5	0.833
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NC_010381	Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence	15009-15038	5	0.833
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	MT075580	Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence	64448-64477	5	0.833
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP014644	Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence	97370-97399	5	0.833
NZ_CP043612_8	8.2\|3489636\|27\|NZ_CP043612\|CRISPRCasFinder	3489636-3489662	27	NC_014533	Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence	490517-490543	6	0.778
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP013280	Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-5-100K, complete sequence	63519-63548	6	0.8
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP039726	Bacillus thuringiensis strain BT-59 plasmid p5, complete sequence	72565-72594	6	0.8
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP009350	Bacillus thuringiensis HD1002 plasmid 4, complete sequence	92349-92378	6	0.8
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NC_018510	Bacillus thuringiensis HD-789 plasmid pBTHD789-3, complete sequence	203311-203340	6	0.8
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP017573	Bacillus thuringiensis strain SCG04-02 plasmid PSCG61, complete sequence	54769-54798	7	0.767
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NC_014533	Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence	59534-59563	7	0.767
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NC_014533	Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence	479559-479588	7	0.767
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_MK275622	Clostridium perfringens strain JXJA17 plasmid p4, complete sequence	29321-29350	7	0.767
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	MN855778	Myoviridae sp. isolate 416, complete genome	10862-10891	7	0.767
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_CP032531	Bacillus megaterium NCT-2 plasmid pNCT2_3, complete sequence	1038-1067	8	0.733
NZ_CP043612_8	8.3\|3489693\|30\|NZ_CP043612\|CRISPRCasFinder	3489693-3489722	30	NZ_LR214939	Mycoplasma salivarium strain NCTC10113 plasmid 2	392367-392396	8	0.733
NZ_CP043612_10	10.1\|5121553\|30\|NZ_CP043612\|CRISPRCasFinder	5121553-5121582	30	MK448887	Streptococcus phage Javan258, complete genome	3504-3533	8	0.733
NZ_CP043612_7	7.2\|2066448\|34\|NZ_CP043612\|PILER-CR	2066448-2066481	34	NZ_LR215032	Mycoplasma gallopavonis strain NCTC10186 plasmid 2	306634-306667	11	0.676

1. spacer 2.1|1170788|24|NZ_CP043612|CRISPRCasFinder matches to NZ_CP013927 (Alteromonas stellipolaris strain LMG 21861 plasmid pASTE61-200, complete sequence) position: , mismatch: 2, identity: 0.917

ttaaggcctaaagcaatacaaaaa	CRISPR spacer
ttaatgccaaaagcaatacaaaaa	Protospacer
**** *** ***************

2. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to MN855801 (Bacteriophage sp. isolate 103, complete genome) position: , mismatch: 3, identity: 0.88

taaaaaaattattaacagcagtaga	CRISPR spacer
tgaaaaaattagtaacagcagtagt	Protospacer
*.********* ************

3. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to MK250021 (Prevotella phage Lak-B2, complete genome) position: , mismatch: 4, identity: 0.84

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaagtattaacatcagtatt	Protospacer
******** ******** *****

4. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to MK250024 (Prevotella phage Lak-B5, complete genome) position: , mismatch: 4, identity: 0.84

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaagtattaacatcagtatt	Protospacer
******** ******** *****

5. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to MK250028 (Prevotella phage Lak-B9, complete genome) position: , mismatch: 4, identity: 0.84

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaagtattaacatcagtatt	Protospacer
******** ******** *****

6. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to MK250025 (Prevotella phage Lak-B6, complete genome) position: , mismatch: 4, identity: 0.84

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaagtattaacatcagtatt	Protospacer
******** ******** *****

7. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to MK250022 (Prevotella phage Lak-B3, complete genome) position: , mismatch: 4, identity: 0.84

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaagtattaacatcagtatt	Protospacer
******** ******** *****

8. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to MK250020 (Prevotella phage Lak-B1, complete genome) position: , mismatch: 4, identity: 0.84

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaagtattaacatcagtatt	Protospacer
******** ******** *****

9. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to NZ_CP014200 (Escherichia coli strain MRE600 plasmid pMRE600-2, complete sequence) position: , mismatch: 5, identity: 0.8

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaattattaaaagcaggctt	Protospacer
*************** *****

10. spacer 1.1|737726|25|NZ_CP043612|CRISPRCasFinder matches to NZ_CP042885 (Escherichia coli O10:H32 strain NMBU-W12E19 plasmid pNMBU-W12E19_01, complete sequence) position: , mismatch: 5, identity: 0.8

taaaaaaattattaacagcagtaga	CRISPR spacer
taaaaaaattattaaaagcaggctt	Protospacer
*************** *****

11. spacer 8.2|3489636|27|NZ_CP043612|CRISPRCasFinder matches to MG543995 (Staphylococcus phage UPMK_1, partial genome) position: , mismatch: 5, identity: 0.815

tctaaaaaaagagcttttattaccttt	CRISPR spacer
acaaaaaaaagagcttttattattatt	Protospacer
 * *******************.. **

12. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 5, identity: 0.833

ttataaaaaaaaggattttat-gttatcccg	CRISPR spacer
ttataaaaaaaaggatttaatcgttcactc-	Protospacer
****************** ** ***  *.*

13. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP014857 (Lysinibacillus sphaericus III(3)7 plasmid, complete sequence) position: , mismatch: 5, identity: 0.833

ttataaaaaaaaggattttat-gttatcccg	CRISPR spacer
ttataaaaaaaaggatttaatcgttcactc-	Protospacer
****************** ** ***  *.*

14. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NC_010381 (Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequence) position: , mismatch: 5, identity: 0.833

ttataaaaaaaaggattttat-gttatcccg	CRISPR spacer
ttataaaaaaaaggatttaatcgttcactc-	Protospacer
****************** ** ***  *.*

15. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to MT075580 (Lysinibacillus sphaericus strain SSII-1 plasmid pSSII-1, complete sequence) position: , mismatch: 5, identity: 0.833

ttataaaaaaaaggattttat-gttatcccg	CRISPR spacer
ttataaaaaaaaggatttaatcgttcactc-	Protospacer
****************** ** ***  *.*

16. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP014644 (Lysinibacillus sphaericus strain OT4b.25 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.833

ttataaaaaaaaggattttat-gttatcccg	CRISPR spacer
ttataaaaaaaaggatttaatcgttcactc-	Protospacer
****************** ** ***  *.*

17. spacer 8.2|3489636|27|NZ_CP043612|CRISPRCasFinder matches to NC_014533 (Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence) position: , mismatch: 6, identity: 0.778

tctaaaaaaagagcttttattaccttt	CRISPR spacer
tctaaaacaagagcttttattggttaa	Protospacer
******* *************. .*

18. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP013280 (Bacillus thuringiensis serovar israelensis strain AM65-52 plasmid pAM65-52-5-100K, complete sequence) position: , mismatch: 6, identity: 0.8

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
ctataaaaataaggattttatgttatttta	Protospacer
.******** ****************....

19. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP039726 (Bacillus thuringiensis strain BT-59 plasmid p5, complete sequence) position: , mismatch: 6, identity: 0.8

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
ctataaaaataaggattttatgttatttta	Protospacer
.******** ****************....

20. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP009350 (Bacillus thuringiensis HD1002 plasmid 4, complete sequence) position: , mismatch: 6, identity: 0.8

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
ctataaaaataaggattttatgttatttta	Protospacer
.******** ****************....

21. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NC_018510 (Bacillus thuringiensis HD-789 plasmid pBTHD789-3, complete sequence) position: , mismatch: 6, identity: 0.8

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
ctataaaaataaggattttatgttatttta	Protospacer
.******** ****************....

22. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP017573 (Bacillus thuringiensis strain SCG04-02 plasmid PSCG61, complete sequence) position: , mismatch: 7, identity: 0.767

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
ctataaaaataaggtttttatgttattttt	Protospacer
.******** **** ***********...

23. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NC_014533 (Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence) position: , mismatch: 7, identity: 0.767

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
gattaaaaataaggattttatgtcatccgc	Protospacer
   ****** *************.****

24. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NC_014533 (Gloeothece verrucosa PCC 7822 plasmid Cy782201, complete sequence) position: , mismatch: 7, identity: 0.767

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
aattaaaaaaaacgattttatgtcatccac	Protospacer
   ********* **********.****

25. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_MK275622 (Clostridium perfringens strain JXJA17 plasmid p4, complete sequence) position: , mismatch: 7, identity: 0.767

ttataaaaaaaaggattttat----gttatcccg	CRISPR spacer
ttataaaaataaggattttataagaaatat----	Protospacer
********* ***********    . ***

26. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to MN855778 (Myoviridae sp. isolate 416, complete genome) position: , mismatch: 7, identity: 0.767

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
caagaaaaaaacggattttattttatcgct	Protospacer
. * ******* ********* ***** *

27. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_CP032531 (Bacillus megaterium NCT-2 plasmid pNCT2_3, complete sequence) position: , mismatch: 8, identity: 0.733

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
gtataaaaaccaggattttatgtttttaaa	Protospacer
 ********  ************* *.  .

28. spacer 8.3|3489693|30|NZ_CP043612|CRISPRCasFinder matches to NZ_LR214939 (Mycoplasma salivarium strain NCTC10113 plasmid 2) position: , mismatch: 8, identity: 0.733

ttataaaaaaaaggattttatgttatcccg	CRISPR spacer
ttgctaaaaaaacgattttatgttatattt	Protospacer
**.. ******* ************* ..

29. spacer 10.1|5121553|30|NZ_CP043612|CRISPRCasFinder matches to MK448887 (Streptococcus phage Javan258, complete genome) position: , mismatch: 8, identity: 0.733

aaaaatctatttcataaactagagtattcg	CRISPR spacer
aaaaatctatttcttaaactatatgaggaa	Protospacer
************* ******* *  *   .

30. spacer 7.2|2066448|34|NZ_CP043612|PILER-CR matches to NZ_LR215032 (Mycoplasma gallopavonis strain NCTC10186 plasmid 2) position: , mismatch: 11, identity: 0.676

tgacgcttgtccagatgttgctggtttagctgct	CRISPR spacer
gaaaaaaactccatatgctgctggtttagctgca	Protospacer
 .* .    **** ***.***************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1999077 : 2007411

Klosneuvirus(11.11%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_111377549.1\|1999077_1999770_+	NUDIX hydrolase	A0A1V0SIB1	Klosneuvirus	2.3e-09	35.1
WP_111377548.1\|1999844_2000678_+	ribose-phosphate pyrophosphokinase	A0A0S1RV70	Klebsiella_phage	4.9e-43	42.9
WP_111377601.1\|2000803_2001331_+	NADAR family protein	A0A0E3TB23	Enterococcus_phage	8.7e-38	45.9
WP_111377547.1\|2001341_2001848_+	O-acetyl-ADP-ribose deacetylase	A0A0K1L687	Scale_drop_disease_virus	5.6e-34	46.6
WP_111377546.1\|2001889_2002438_+	RNA 2'-phosphotransferase	A0A2R2ZGT8	Clostridioides_phage	1.0e-52	52.5
WP_111377545.1\|2002457_2003297_+	ADP-ribosylglycohydrolase family protein	NA	NA	NA	NA
WP_111377544.1\|2003299_2004031_+	serine/threonine protein phosphatase	S0A0Y6	Cellulophaga_phage	1.5e-40	35.2
WP_111377543.1\|2004033_2004495_+	hypothetical protein	K4JW05	Caulobacter_phage	1.6e-27	50.8
WP_111377542.1\|2004491_2005961_+	nicotinate phosphoribosyltransferase	A0A218KC49	Bacillus_phage	9.9e-156	57.1
WP_111377541.1\|2006148_2006730_-	nicotinate-nucleotide adenylyltransferase	NA	NA	NA	NA
WP_111377540.1\|2006838_2007411_-	guanylate kinase	A0A1W6JK60	Lactococcus_phage	8.1e-13	33.6

DBSCAN-SWA_2

4097443 : 4169069

Cafeteria_roenbergensis_virus(40.0%)

transposase,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_142479141.1\|4097443_4097617_+\|transposase	IS6 family transposase	NA	NA	NA	NA
WP_111375731.1\|4098310_4098694_+	hypothetical protein	NA	NA	NA	NA
WP_111375755.1\|4106659_4107964_+	HAMP domain-containing histidine kinase	Q8QKV7	Ectocarpus_siliculosus_virus	1.7e-13	26.1
WP_111375754.1\|4107973_4108402_+	response regulator	NA	NA	NA	NA
WP_111375753.1\|4108577_4109243_+	hypothetical protein	NA	NA	NA	NA
WP_111375752.1\|4109283_4109793_+\|tail	phage tail protein	E3T4R8	Cafeteria_roenbergensis_virus	4.1e-16	36.3
WP_111375751.1\|4109817_4110339_+\|tail	phage tail protein	E3T4R8	Cafeteria_roenbergensis_virus	1.3e-17	34.4
WP_111375750.1\|4110389_4110905_+\|tail	phage tail protein	A0A222ZFV4	Arthrobacter_phage	9.2e-16	32.6
WP_111375749.1\|4110916_4111414_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_111375748.1\|4111436_4111736_+	hypothetical protein	NA	NA	NA	NA
WP_167511677.1\|4111760_4117151_+	cadherin-like domain-containing protein	NA	NA	NA	NA
WP_111376028.1\|4118019_4120884_-	hypothetical protein	NA	NA	NA	NA
WP_111376027.1\|4122033_4123269_-	hypothetical protein	NA	NA	NA	NA
WP_111376026.1\|4123232_4124015_-	GLPGLI family protein	NA	NA	NA	NA
WP_111376025.1\|4124018_4126817_-	outer membrane beta-barrel protein	NA	NA	NA	NA
WP_111376024.1\|4127252_4128275_-	hypothetical protein	NA	NA	NA	NA
WP_111376023.1\|4128271_4129552_-	glutamate decarboxylase	NA	NA	NA	NA
WP_111376022.1\|4129629_4130700_-	hypothetical protein	NA	NA	NA	NA
WP_111376021.1\|4130759_4131578_-	hypothetical protein	NA	NA	NA	NA
WP_111376020.1\|4131596_4132838_-	TolC family protein	NA	NA	NA	NA
WP_111376019.1\|4132859_4133072_-	hypothetical protein	NA	NA	NA	NA
WP_111376018.1\|4133177_4133567_-	hypothetical protein	NA	NA	NA	NA
WP_111376017.1\|4133599_4134055_-	DUF2589 domain-containing protein	NA	NA	NA	NA
WP_111376016.1\|4134072_4134354_-	hypothetical protein	NA	NA	NA	NA
WP_111376015.1\|4134381_4135089_-	DUF2589 domain-containing protein	NA	NA	NA	NA
WP_111376014.1\|4135114_4135711_-	hypothetical protein	NA	NA	NA	NA
WP_111376012.1\|4136750_4137497_+	response regulator transcription factor	NA	NA	NA	NA
WP_142479134.1\|4138008_4138401_+	hypothetical protein	NA	NA	NA	NA
WP_111376010.1\|4138739_4139042_+	urease subunit gamma	NA	NA	NA	NA
WP_111376009.1\|4139060_4139432_+	urease subunit beta	NA	NA	NA	NA
WP_111376008.1\|4139428_4141150_+	urease subunit alpha	NA	NA	NA	NA
WP_111376007.1\|4141228_4141816_+	hypothetical protein	NA	NA	NA	NA
WP_111376006.1\|4141815_4142319_+	urease accessory protein UreE	NA	NA	NA	NA
WP_111376030.1\|4142320_4143010_+	urease accessory protein UreF	NA	NA	NA	NA
WP_111376005.1\|4143055_4143694_+	urease accessory protein UreG	NA	NA	NA	NA
WP_111376004.1\|4143698_4144496_+	urease accessory protein UreD	NA	NA	NA	NA
WP_111376003.1\|4144502_4145201_+	hypothetical protein	NA	NA	NA	NA
WP_111376002.1\|4145235_4146120_+	urea transporter	NA	NA	NA	NA
WP_111376001.1\|4146125_4148183_+	TonB-dependent receptor plug domain-containing protein	NA	NA	NA	NA
WP_111376000.1\|4148195_4148999_+	DUF2490 domain-containing protein	NA	NA	NA	NA
WP_111375999.1\|4149055_4150285_+	reactive intermediate/imine deaminase	NA	NA	NA	NA
WP_111375998.1\|4150404_4151289_-	AraC family transcriptional regulator	NA	NA	NA	NA
WP_111375997.1\|4151636_4152497_+	AraC family transcriptional regulator	NA	NA	NA	NA
WP_111375996.1\|4152619_4153951_+	amidohydrolase family protein	NA	NA	NA	NA
WP_111375995.1\|4153962_4154631_+	ankyrin repeat domain-containing protein	NA	NA	NA	NA
WP_111375994.1\|4154704_4155541_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_111375993.1\|4155646_4155955_-	hypothetical protein	NA	NA	NA	NA
WP_111375992.1\|4156193_4157624_-	hypothetical protein	NA	NA	NA	NA
WP_111376029.1\|4157647_4162228_-	molybdopterin-dependent oxidoreductase	A0A0P0I429	Acinetobacter_phage	5.8e-85	33.3
WP_111375991.1\|4162879_4163857_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_111375990.1\|4163997_4164309_+	EthD family reductase	NA	NA	NA	NA
WP_111364648.1\|4164541_4164784_+	hypothetical protein	NA	NA	NA	NA
WP_142479133.1\|4164805_4165309_-	DNA-deoxyinosine glycosylase	NA	NA	NA	NA
WP_149229161.1\|4166257_4166857_+\|transposase	transposase	NA	NA	NA	NA
WP_111375720.1\|4166762_4167284_-	DNA-deoxyinosine glycosylase	NA	NA	NA	NA
WP_142479148.1\|4167600_4168257_+	hypothetical protein	NA	NA	NA	NA
WP_149229162.1\|4168469_4169069_+\|transposase	transposase	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP043612

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection