CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP029196	Streptomyces venezuelae strain ATCC 21113 chromosome, complete genome	24 crisprs	csa3,WYL,DEDDh,cas4,cas3,DinG	4	9	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP029196_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_1

503668-503758

Orphan

Consensus_repeat	Method
GCCGGGACGCCGGGACCGGTGTCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_1

>merge|NZ_CP029196|1|503668-503758|CRISPRCasFinder
GCCGGGACGCCGGGACCGGTGTCGCCCCCACCCCTCCTACGGGGTCTCCCCCGCGCCGGCCCGGGGCCGGGACGCCGGGACCGGTGTCGCC

>NZ_CP029196|1|1|503668-503758|CRISPRCasFinder
GCCGGGACGCCGGGACCGGTGTCGCC	CCCACCCCTCCTACGGGGTCTCCCCCGCGCCGGCCCGGG
GCCGGGACGCCGGGACCGGTGTCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150163459.1\|501879_502278_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP029196.1\|WP_150158879.1\|504873_505434_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150158883.1\|505817_507248_-\|amidase	unknown	unknown	gnl\|CDD\|181154
NZ_CP029196.1\|WP_150158892.1\|511248_511944_+\|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl\|CDD\|225002
NZ_CP029196.1\|WP_150158875.1\|502481_503456_+\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274373
NZ_CP029196.1\|WP_150158888.1\|508917_510315_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|273327
NZ_CP029196.1\|WP_150158894.1\|511932_515910_-\|acyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|225858
NZ_CP029196.1\|WP_150158863.1\|497335_497986_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150158877.1\|504250_504643_-\|anti-sigma-factor-antagonist	unknown	unknown	gnl\|CDD\|132914
NZ_CP029196.1\|WP_150158881.1\|505516_505840_+\|plasmid-stabilization-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150158859.1\|495510_496251_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
NZ_CP029196.1\|WP_150158865.1\|498120_498816_+\|response-regulator	unknown	unknown	gnl\|CDD\|223816
NZ_CP029196.1\|WP_150158861.1\|496247_497339_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP029196.1\|WP_150158873.1\|501472_501886_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP029196.1\|WP_150158866.1\|498812_500306_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP029196.1\|WP_150158890.1\|510411_511215_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|180591
NZ_CP029196.1\|WP_150158869.1\|500302_500797_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150158871.1\|500809_501391_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238042
NZ_CP029196.1\|WP_150158896.1\|515911_522577_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|225858
NZ_CP029196.1\|WP_150158885.1\|507456_508887_+\|rifampin-monooxygenase	unknown	unknown	gnl\|CDD\|235870

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150163459.1\|501879_502278_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.0815e-12
NZ_CP029196.1\|WP_150158883.1\|505817_507248_-\|amidase	gnl\|CDD\|181154	PRK07869, PRK07869, amidase; Provisional.	0
NZ_CP029196.1\|WP_150158892.1\|511248_511944_+\|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl\|CDD\|225002	COG2091, Sfp, Phosphopantetheinyl transferase [Coenzyme metabolism].	3.02829e-41
NZ_CP029196.1\|WP_150158885.1\|507456_508887_+\|rifampin-monooxygenase	gnl\|CDD\|235870	PRK06834, PRK06834, hypothetical protein; Provisional.	2.01512e-157
NZ_CP029196.1\|WP_150158888.1\|508917_510315_-\|MFS-transporter	gnl\|CDD\|273327	TIGR00895, transport_protein, benzoate transport. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	8.32805e-59
NZ_CP029196.1\|WP_150158894.1\|511932_515910_-\|acyltransferase-domain-containing-protein	gnl\|CDD\|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_CP029196.1\|WP_150158896.1\|515911_522577_-\|AMP-binding-protein	gnl\|CDD\|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
NZ_CP029196.1\|WP_150158877.1\|504250_504643_-\|anti-sigma-factor-antagonist	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.87811e-28
NZ_CP029196.1\|WP_150158875.1\|502481_503456_+\|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274373	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. This group of similar sigma-70 factors includes clades found in Bacilli (including the sporulation factors SigF:TIGR02885 and SigG:TIGR02850 as well as SigB:TIGR02941), and the high GC gram positive bacteria (Actinobacteria) where a variable number of them are found depending on the lineage.	7.75596e-99
NZ_CP029196.1\|WP_150158859.1\|495510_496251_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.15108e-104
NZ_CP029196.1\|WP_150158865.1\|498120_498816_+\|response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	6.60554e-83
NZ_CP029196.1\|WP_150158861.1\|496247_497339_-\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	8.93525e-08
NZ_CP029196.1\|WP_150158873.1\|501472_501886_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.21257e-20
NZ_CP029196.1\|WP_150158866.1\|498812_500306_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.16687e-43
NZ_CP029196.1\|WP_150158890.1\|510411_511215_-\|enoyl-CoA-hydratase	gnl\|CDD\|180591	PRK06494, PRK06494, enoyl-CoA hydratase; Provisional.	6.58066e-134
NZ_CP029196.1\|WP_150158871.1\|500809_501391_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.39954e-06

>NZ_CP029196.1|WP_150158875.1|502481_503456_+|SigB/SigF/SigG-family-RNA-polymerase-sigma-factor
MSNHRTTARTGRTPALPASAGPEPAEALAGLPEIADPLAVSTSDARTLSTALFERLRSLEEGTASYSYVRNTLVELNLSLVKYAATRFRHSSENWEDLVQVGTVGLIKAINRFDPARGNEFMSFALPTVLGEIRRHLRDTSWSVHVPRRLQELRLDVAKANDALEQELGRPPTSAELGDRLHITEDELREGRIAANGFASRSLDVPVDDEDAGPGMLARCLGTEDDAFEKVLNLEALKPLVAALSERDRAILALRFGDELTQAEIGERLGLSQMHVSRLLSRILGGLRTALTTEDPSATAAATGSPGSGTRGTAAAQRAAAKRT
>NZ_CP029196.1|WP_150163459.1|501879_502278_-|ATP-binding-protein
MNRHPVPRDAAEARARVAQALEVAALGPGAPPSATAVGDALLVTSELVTNALRHAGGLTGFDVDVDASAVTISVADPSAELPRLTDVRRRERACGAAEGGFGWPLVRQLAEEVRVFLPPDDGKTIEARLPLH
>NZ_CP029196.1|WP_150158873.1|501472_501886_+|STAS-domain-containing-protein
MRMMVVKQPTVADPWEPTMNPTPLAAVPAAPPRMTTDVTPDGTLLVSGEIDASTASTLLRALTDALRAHPGGVALDLSAVTFCDCAGLRAFLAARYQHLDIGRLPLRVVAASPRMTRLLRLTGTGWLFVEPRTGPVQ
>NZ_CP029196.1|WP_150158871.1|500809_501391_-|MarR-family-transcriptional-regulator
MSDSAGDRQSWTFLTNHARVLVVIARDPGVRLRDVAAACGVTERTVQAIVADLEAAGYLTHAREGRRNRYRLAPGKRFRHPLEGDYEITGLLDLLRASPGNGTTGRHTAERDGDGRARAGRPDGDHAEHDGDGRSWAGRPDGDHAERDGNGRSRAGRPNGDHPNGDRADEDSPDGDHDHDGAPRPGADSRVLR
>NZ_CP029196.1|WP_150158869.1|500302_500797_+|hypothetical-protein
MRVRAGVLLGVLGTALVGCGVQPTGVIGAGEPATGLTRGVRLYFASDAGLRSVPVLDREVTDLNSVVKLLAAGPPPAERRDGLTNLVDIGGYTVTGRGTGVTVRLEEPYPGSGRDQGTGQLVCSLARAQSVLDPKVRADDVRVTLVPPEGPGLGPYRCAEFLDR
>NZ_CP029196.1|WP_150158866.1|498812_500306_+|HAMP-domain-containing-protein
MRGRGRGGRSRRLVGGLRTRLVVTFVVVALVSAVTATALAYRDARTAVLRRTQDAAVDDVRTRVTAVAADFDLPPDQRTLSRFAAKISDGLGARLVVARHRDLVAASDPLADTDGRITVALRSAVRAGDGARFQRVTWRDEPYLVVGMPVTYADGDRRASGLEVFVITDLRAERDDTAALLDSVRTGILPVVALAAVLALLAAGTVLRPVRKLGRATRSLAAGELGSRVAVRGHDELADLARTFNETAAALQASDARLRDQEAKARRFVADVSHELRTPLAAMTMVATVLEEDADQLPPDAARAARTVGAETARLSRLVEDLMEISRFDANAVELNAAETDLADTVRASLALRGWTDRVEVRLDEGVRAVVDRRRVDVIVANLVGNALRHGAPPVVVTLGTGVAADGGAWVALEVADHGLGLPPEARERVFDRFYKADTARTRSASDTGGQGSGLGTAIALENARLHGGTIEVAEGPEGGAVFTLRLPLRRTGEDTE
>NZ_CP029196.1|WP_150158865.1|498120_498816_+|response-regulator
MPHVLLIEDDASVRDGMELVLRRHGYGVDTAATGEEALALLDAPEGARVELAVLDLMLPGMDGFEVCRRIRARTTTLPVIMLTARGDDHDIVTGLEAGADDYVVKPVTAPVLEARIRAALRRAEPSAVSRAAGADLAGLVIDRAALTVTKHGVPVPLPPTELRLLLELSASPGRVLSREQLLASVWDHTFLGDSRLVDAAVGRLRAKLEDVPARPRYVQTVRGFGYRFGPL
>NZ_CP029196.1|WP_150158863.1|497335_497986_-|hypothetical-protein
MSQQTTSRVPARLRLTALAALPVLVLTVACGGGDGAGGAPKNDAIASVPETVTATPAAKDTAGPSAGPAGKSAFYDAQLVYVRCMRVKGGYQDFPDPKLSGHLDWGKVEEISSRPGQMEAAKGGRNGVCVPELQKVMQAEPARDQQKDYESMLAHAKCMRDNGISRFTNPTMSGGNAQPGGDPNPADPAIDSGSPAYKQAREACKAKLLDGLDGMQ
>NZ_CP029196.1|WP_150158861.1|496247_497339_-|peptidoglycan-binding-protein
MKRRTALRTLGAVTVATAVTGGVVLLGDPLGGAPGSGAAGRSGDAPPATATVVRTDLVRAKTVDGTLDFAQRRPVKSAVEGTVTVAATEGRTVTRGQALYELDDKPVTLLYGPVPVFREMKTGDRGSDVLQLERNLRDLGHGAGLYVDTRYDKDTETAVKRWQKSLNREPTGRVGKGEVVFQPGQVKVVSADAALADQVGPDRPVLTVASTRPVVRARLDQTDGPLTAAGTKVEVTLPSGRTAAGRVAGTVRPEDTGTGDGTAGQDGIVVEVVLDGGTRAASGEDTKAPVSVRFVSESRKGVLAVPVEAVLALRGENGGYGLQIVQGGTTTTIRVETGMTADGRIEVSGPDVREGLTVGVAAS
>NZ_CP029196.1|WP_150158859.1|495510_496251_-|ATP-binding-cassette-domain-containing-protein
MSHAPAPAPAHPAPTPVVELRNATKAYPGGVHALRGVNLTVDAGELLAVVGPSGSGKSTMLHVMGTLDKPTSGTVRIAGHEVSALSDNRLSALRARHIGFVFQHFHLAAGRDAVDNVADGLLYAGVPLRERRARAREALARVRLDHRGSHRPHQLSGGEKQRVAIARALVGEPLLLLADEPTGALDTASGEIVMELLHELNATGTTICVITHDNEIANSLPRRVRFKDGEIVADERPDSREGGATS
>NZ_CP029196.1|WP_150158877.1|504250_504643_-|anti-sigma-factor-antagonist
MPRDATVTGDVGPTGPRLTAAVRWSGATAVVTVKGELDRDTQEPLREALAGALERRPERIVVDCAQLAFCDSTGLNLLLTTRLEAIEAGGGLELAALSPPVARVFDITGVIAVFTVYEELPGELAQGEQP
>NZ_CP029196.1|WP_150158879.1|504873_505434_+|hypothetical-protein
MADDDTGRESDDGRGRTGGPGATGAAGRRRGREETADERADRQWQDLLQETRVAQTGVQILLGFLLTVVFTPRFESLGSADKGIYILTVVLGSLATGALIGPVSFHRLVAGRRIKPHAVTWASRLILVGIVLLLATLTSALFLILRVATDDGLVPWIVGAVLAWYLLCWFALPLWARRRHTAEREE
>NZ_CP029196.1|WP_150158881.1|505516_505840_+|plasmid-stabilization-protein
MPRGSSPKRERQYEHIKESAEQRGESEERAKEIAARTVNKERARHGESETASKLSLEDMSSGERGGKRSHSGAQGRTYDQLYEEARRRNLDGRSKMNKAQLKRALGD
>NZ_CP029196.1|WP_150158883.1|505817_507248_-|amidase
MTTFEERETVHAFRDDALGEHDAVGLAEAMRRGEVGAAEVAEDAAERVRQVEARLHAVQTHIDAPVPGTAGGALAGVPTFVKDNTDFLGLPTGHGSAAFTPRTARRHAPFARQLLSSGVTVLGKTRLPEFGFSPATEYEHAEPVRNPWNTAYSAGGSSGGSAALVAAGAVPIAHANDGGGSIRIPAACCGLVGLKPTRGRVVTNDQSRRLPLDIVSDGIVSRSVRDTAAFLAAAETHWRNPALPPLGLVEGPSDRRLRIGFLVDSPNGVRADAVTRAAVDETVATLERLGHTVEPVELDLDPRFTEDFLVYWGLLSFLIGVTGRTFGADFDRHRMDGLSRGLREEYLKSWRRTPAVLRRLKRTKVAYAAAFRGLDLVLTPVLAHTTPRIGHLSPTVPYPTLVERILAYVAFTPVNNVVGTPSISVPAATTTPDGLPVGVMFSGRPGSERTLLEVAYALEADRPFRRIQDVSRPERA
>NZ_CP029196.1|WP_150158885.1|507456_508887_+|rifampin-monooxygenase
MIDVIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQSRAQGLHVRSIEVMAQRGLLERFLERGHTVAVGGFFAGLATSWPERLDTAHSYVLAVPQVITEQLLAEHATALGAEIRRGRALVGLRQDEDGVTVDLADGEQLRARYVVGCDGGRSTVRKLLGVAFPGEPSRVETLLGEMEMTASQEELTSVMTEVRKTQQRFGAMPLGDGVFRVVVPAEGVVEDRTAAPTLDEFKQQLRAHAGTDFGVHSPRWLSRFGDATRQAERYRVDRVFLAGDAAHIHPPTGGQGLNLGIQDAFNLGWKLAAEVDGWAPEGLLDTYHAERHPVATEVLDNTRAQIQLMSTEPGPQAVRRLMAELVEFENVNRYLIEKITAISVRYDVGEGHELLGRRMRDLALKHGRLYERMHEGRGLLLDQTGRLSVAGWEDRVDHVVEVSEELEVPAVLLRPDGHVVWAGENQQELLTRLPAWFGAATAG
>NZ_CP029196.1|WP_150158888.1|508917_510315_-|MFS-transporter
MRLHSAPGPGRAGAPPPPARLSVQEFLDGTPMGPRQRLVALIGLVVMIAEGLDISIASFVYPHLIRDWGTSMSAVTTTVTAGVLSMAAGGAVAGPLADRYGRKGVTVAGLLLFGAATAAMALTTTVGPFATLRVVACAGLGAVAPVVMAVVADATPAARRAPVVALAFAGVAAGTVAGGLFASTVIPGLGWPAALAICGLAPLLLIPLVVAYVPESVSVLLARGRPAERIRETLALLAPGRDTSHVDLTGARDQERQPRRPVGALVLSRAFTGTTLLIWFCYFVLLGVVFLLLNYLPLLGERAGLTAARTGFAVGLFGAGTLCGQLLASLGLRRYDRFRALALASSLSALVVGVTAAVRTGHTGMFVLVAVLGVCLGASLGALQAVGALAYPATLRATGMGWMSGWGRLGTLASGVLGGVLIGAGWGISQLFLLLCVPLAVTGAAALALRREVTRRGGGVEGPRP
>NZ_CP029196.1|WP_150158890.1|510411_511215_-|enoyl-CoA-hydratase
MLDDLRCVRYEKRGHVAYVTLDRPHVLNATDLRTHAELARVWDDFEADDDLWVGVLTGAGERSFSVGQDLKELAGRDERGTPPATFGSRGKPGWPRLTERFSLFKPLIARVNGYALGGGFELAMACDIVIAAEHAEFALTEARLGLVAGAGGVFRLTRQAPFRVAMGHLLTGRRMTAVRAYELGLVNEVVPAHRLDACLDGWVEDVLSCAPLALRAAKEAATVSAGLPLERAFATRYVWEERRMVSRDAVEGPRAFVEKRPPKWTGT
>NZ_CP029196.1|WP_150158892.1|511248_511944_+|4'-phosphopantetheinyl-transferase-superfamily-protein
MTSEISPVRVLRAGAGPDPSVPPVVDGSVALWLVPVTADPGAYQLLDAGERQRSAALLREADRTRYLAAHGGLRRLLGHYLGTPPDEVVFVREDCPLCGGPHGRPAVRDGGIHFSLSHSEDLVLVGVAGRPVGVDVEAFPAAGVSDLVADTLHPREREEFARLAPEVRTAAFTRCWVRKEAYLKGTGEGLAGGLERTYVGTGPGPAAVPGWSLTDVPVGPSYAAAVALSQQ
>NZ_CP029196.1|WP_150158894.1|511932_515910_-|acyltransferase-domain-containing-protein
MTGTEEKLVDYLKKVTAELHETRRQLRGALAASREPIAIVGMACRYPGGVRTPEALWRLVLDEQDAISGFPTNRGWDIDGIYHPDPDRPGTCYAREGGFLHDAALFDAEFFGVSPREAQAMDPQQRLLLETAWEAFERAGIDPTSLRGSDTGVFAGVVHHDYATARVPETLEPYLVTGLSGGVASGRIAYTFGFEGPAVTVDTACSSSLVALHQAAHALRSGECELALAGGVTIMATPRAFLSFSRQRGLSPDGRCRAFGAGADGTGWAEGAGMLLVERLSDARRKGHPVLAVLRGSAVNQDGASNGLSAPNGPSQQRVIRKALAHAGLAARDVDVVEGHGTGTKLGDPIEAQALLATYGQERDEGLPLHLGSMKSNVGHSQAAAGVGGVIKMIEAMRHGILPRTLHADEPTPHVDWSAGDIELLTRRRAWPETGRPRRAAVSSFGISGTNAHVILEAPPEEPARDAAESRPEVPSREAAESRPEAAGQGRTETGPGPSATPPEAPGRARPPVPWPLSGRDPGALRDQIGRLRAHLDAAPADPEDVAHSLARRAVFRHRAVLLAAPQAPAGGSPRAVTGVARPGGTALLFSGQGSQRVGMGRELYETYPVFAESFDAVAEHTGLPLKDVVLAGTPDGLLDRTRYAQPALFAVEVSLFRLVRALGLDVRAVVGHSVGEIAAAHAAGVMSLADACRLVEARGRLMDALPPGGAMVAVEVSEAEASAALAGLEDRVAVAAVNGPASTVLSGEEGAVLKLADAWRERGVRTHRLTVSHAFHSPLMEPMVDAFREVVAGLDLHRPTLAGLPAEVVDPEYWVRHVRRPVRFADAVARAREAGAVRWLEVGPGGVLTALAQRIVPDTEEHVFAAALRTDRPEPEALLVALSQVHVDGGTVHWSGLCAGGRLVDLPTYPFQRQHYWIEDQPLPPTAPTPGTAPSGTGTAAEGAAAAEVPLSERLARLTGAERLAAVRELVLAEASETLGHTGTLITADRTRQELGFDSLTAIELRNRISRTLGVRLPPTLVFDHEDLGEIASFVDARLDDAATGRSTGHGPLGEDGSGLLTELFREAAAAGRLDDAVTLTEAAARMRRTFTDAEDPAVRRTPVWFGRGPARPTVVCLPSFSAIAGVHVYARFADAFGDGWRVAALAHPGFVPGEPLPDSVDVLAELHARTVLDTVGADPFLLVGRSAGGWVAHEVAAVLERMGRAPDGVALLDTPARADDPRGHAVMVGGMLERDSRLVTIDDYRLTAMGGYSRLFREWKPEPIAAATLLVHAATPYGADEARIASWELPHQAVKVTGDHFTMLERHSATTAEAVEQWSRSLL
>NZ_CP029196.1|WP_150158896.1|515911_522577_-|AMP-binding-protein
MTQVDDIRPLSAVLRAHALDRPDKVAFADEERHVTYARLAERTGRLAGHLAGHGLRRGDRVAILLGNSVTTVESYLAVTRAAAVGVPVNPQSSDAELAHQLDDSGARFVITDGPHLDQVERLRATREGIRVVLARGYGPGGGPHGSGPEAPASEGTPAPEKGTPAPDGPLSFEELAGSEPAQAPRDDLGLDEPAWILYTSGTTGAAKGVVSHQRACLWSVRSSYQGVLGLGPDDRLLWPLPLFHSLAHILCVLGVTVSGATARILPGFGARDVLDALRAEPCTMLLGVPSMYLRLVAAVEAVEEAGGSVPKPRLCVVTGAATGPELASAVERVLGAPLVNSYGATETCGAITLSRPDSERPPGTVGTAVPGSELRLVDPRTGRDARTGDEGEVLVRSPGLLLRYHDRPEETAAALRDGWYRTGDLARRDAAGRLTITGRVKELVIRAGENIQPGEIEDVLRTVPGIADAAVTGRPDEALGEVPVAYVVPAAGGWSPAEALAACRERLSYFKVPAELYEIAALPVTGSGKVTRRALPGLPARLRALGTGHHERLWRTTWVRCPAPDAAEPAGAARWAVIGAEVPAFAEAVRRRGGVTETFPDPAAARAAGSFDGHLLTAPAPDPDAPAEAAAESPFRMTDGSPRARTLLLTRSGVSTGPDDPPDPTASAVRARLLARGGDGTVLVDLGPEDPRPVGGFAEAEADGAFAGAAARDADTGDVPGSDVPSPDVEAWLAVLSAPAGETEFALRSGAALVPRLARVRAAGEVALPSGGPGAALVTGAGTGISRVLATHLVVNHGVCDLVLTDAGEDGDPGAVATLAADLTGLGATVTVRTGRPDTAERAAALLGALGPDRPCALIVHPVTAPADAEAAARLLDLTRRSGGTTLLLCGRAAPGDPSEAAAAAHAAALTHDVAHATFLAFGPVAPDAPQPGLAALTAREAGDALDAIRATSGGPALVLRTDPWTLRAPGADRLRRMIPRYTEDTAAPAALDEGLRERLGVLPGRARQRALTALVREEAADVLGLDAPRRIDVGLAFTRLGLTSLTAVALRDRLAARTGLRLPVTLAFDHPTPAAVAAVLDGELFGARPATGAARRTSEDAGTSHRTGPGHDAHDPVVVIGMSCRYPGGIASPEDLWRFVAEGRDAIGPFPTDRGWDLERLLSGDGTAPGTSATGSGGFLDAPGDFDAAFFGVSPREALAMDPQQRLLLEVGWEAVERAGIDPTSLRHTDTGVYVGLMFHDYAQHTGDLPEDLERLLGTGTAGSVASGRLAYTLGLNGPALTVDTACSSSLVAVHLAAQALRRGDCSLALAGGVAVMATPSTFVEFSRQHGLAADGRCKAFGEGADGTGWSEGVGVVALERLSDARRHGHPVLAVIRGSAVNQDGASNGLTAPSGPAQQQVIRRALADAGLTPGDVDAVEAHGTGTVLGDPIEANALLATYGRDRDPERPLLLGSFKSNIGHAQSAAGVGAVIKMVQAIRYGELPRTLHAEPPTSAVDWSGGAVRLLREHTPWPVTGDRRRAAVSSFGVSGTNAHLVLEQAPEPDAPPALPPAVHPETVPVLLSARTPSALRRQAGRVLDAVRADPGLPVPDLAAALATTRTAFPRRAAFVVEGRAELERRLRSFADGEDGGAEPDEVPAEPSLAIGFTGQGSQHPGMGRELYAAFPVFAEALDAAWAALDPHLERPLRDVMWAPDGTARAALLDRTDFTQAALFALEGAQFRLVESWGVVPDLVLGHSVGALTAAHAAGVLSLPDAASLVAARGRLMAALPPGGAMTSIEATEDELRTELLATDGVLAIAAVNGPRSVVVSGEEKAVRAVGEAFRARGRRVTALRVSHAFHSPLMDPMVEEFRAAAARVTYRPPLLPMISDLTGRPAEPAHLRSPDHWVRHVRETVRFADAVRALPGQGVTAFLELGPDRQLTTMAAAGATGSGPALCGGLRRGRSEVRSLLDAVAQAHVRGVPVDWREFFAGGPTRPVDLPVYPFEHRRYWLASAPTRTGGATSVPEAPAQPTGDTPGPDRLRADLAPLTDDERERRLTDLVRGEIAAVAGFDGPHEIEAHRSMTDLGLDSVSAVDLSTRLGACTGLDLPASLAFDHPTSTAIARHLLAALRTQGLTPESGQEAGTDGGTEGGKHAGTRAAEGTVFGALARLEASVDRDRPDAAARDRLVERLRALTARLTEGPAGGRADHTSIGDRIGEATTVDQLFDLIDNELKGP

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Crispr_ID: NZ_CP029196_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_2

862286-862432

Orphan

Consensus_repeat	Method
CCGGGCCCGCACCTCCCCCGC	CRT

3 spacers

The CRISPR arrays of NZ_CP029196_2

>merge|NZ_CP029196|2|862286-862432|CRT
CCGGGCCCGCACCTCCCCCGCGCCTCCCCCCGGGCCCGGCCGGGCCCGCACCTCCCCCCGCACTCCCCCGCGCGTCCCTCGGGCCCGCACCTCCCCCGCGCTCACCCCCGCCTCCCCCGGGCCCAGCCCGGCCCGCACCTCCCCCGC

>NZ_CP029196|2|1|862286-862432|CRT
CCGGGCCCGCACCTCCCCCGC	GCCTCCCCCCGGGCCCGG
CCGGGCCCGCACCTCCCCCCG	CACTCCCCCGCGCGTCCC
TCGGGCCCGCACCTCCCCCGC	GCTCACCCCCGCCTCCCCCGGGCCCAG
CCCGGCCCGCACCTCCCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_015031983.1\|860303_861281_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
NZ_CP029196.1\|WP_150159312.1\|871007_871496_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP029196.1\|WP_041662061.1\|863686_864418_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
NZ_CP029196.1\|WP_150159308.1\|867893_868751_-\|endolytic-transglycosylase-MltG	unknown	unknown	gnl\|CDD\|381750
NZ_CP029196.1\|WP_150159316.1\|874693_876109_+\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP029196.1\|WP_150159292.1\|852969_854382_-\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|238520
NZ_CP029196.1\|WP_150159298.1\|858232_860299_-\|Fe(3+)-hydroxamate-ABC-transporter-permease-FhuB	unknown	unknown	gnl\|CDD\|236720
NZ_CP029196.1\|WP_041663616.1\|862892_863714_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
NZ_CP029196.1\|WP_150159310.1\|869057_870917_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP029196.1\|WP_150159294.1\|854530_855514_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP029196.1\|WP_150159304.1\|864421_865489_+\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270276
NZ_CP029196.1\|WP_150159290.1\|850212_851493_-\|DUF418-domain-containing-protein	unknown	unknown	gnl\|CDD\|225193
NZ_CP029196.1\|WP_150159306.1\|865485_866697_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|234821
NZ_CP029196.1\|WP_150159287.1\|849680_850121_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP029196.1\|WP_015031981.1\|857568_858117_-\|FABP-family-protein	unknown	unknown	gnl\|CDD\|378046
NZ_CP029196.1\|WP_150163479.1\|851550_852606_-\|exo-alpha-sialidase	unknown	unknown	gnl\|CDD\|271234
NZ_CP029196.1\|WP_150159296.1\|855461_857564_-\|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl\|CDD\|224422
NZ_CP029196.1\|WP_150159314.1\|871536_874461_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|223354
NZ_CP029196.1\|WP_150163480.1\|866804_867887_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|224983
NZ_CP029196.1\|WP_150159300.1\|861277_862138_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015031983.1\|860303_861281_-\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	1.71498e-59
NZ_CP029196.1\|WP_150159312.1\|871007_871496_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.78781e-17
NZ_CP029196.1\|WP_041662061.1\|863686_864418_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	3.37275e-98
NZ_CP029196.1\|WP_150159308.1\|867893_868751_-\|endolytic-transglycosylase-MltG	gnl\|CDD\|381750	cd08010, MltG_like, proteins similar to Escherichia coli YceG/mltG may function as endolytic murein transglycosylases. The gene product of Escherichia coli yceG/mltG has been erroneously annotated as an aminodeoxychorismate lyase. Its overexpression has been reported to cause abnormal biofilm architecture, and it has been reported to be part of a putative five-gene operon. More recently it has been proposed to function as a terminase for peptidoglycan polymerization. The family also includes Streptomyces caeruleus NovB, an uncharacterized member of the novobiocin biosynthetic gene cluster.	3.24426e-85
NZ_CP029196.1\|WP_150159316.1\|874693_876109_+\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	8.40683e-24
NZ_CP029196.1\|WP_150159292.1\|852969_854382_-\|M24-family-metallopeptidase	gnl\|CDD\|238520	cd01087, Prolidase, Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.	5.42984e-104
NZ_CP029196.1\|WP_150159298.1\|858232_860299_-\|Fe(3+)-hydroxamate-ABC-transporter-permease-FhuB	gnl\|CDD\|236720	PRK10577, PRK10577, Fe(3+)-hydroxamate ABC transporter permease FhuB.	5.0266e-163
NZ_CP029196.1\|WP_041663616.1\|862892_863714_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.60376e-70
NZ_CP029196.1\|WP_150159310.1\|869057_870917_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.41564e-167
NZ_CP029196.1\|WP_150159294.1\|854530_855514_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	2.09111e-07
NZ_CP029196.1\|WP_150159304.1\|864421_865489_+\|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270276	cd13558, PBP2_SsuA_like_2, Putative substrate binding domain of sulfonate binding protein, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.01192e-112
NZ_CP029196.1\|WP_150159290.1\|850212_851493_-\|DUF418-domain-containing-protein	gnl\|CDD\|225193	COG2311, COG2311, Predicted membrane protein [Function unknown].	6.83063e-63
NZ_CP029196.1\|WP_150159306.1\|865485_866697_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|234821	PRK00719, PRK00719, alkanesulfonate monooxygenase; Provisional.	3.47663e-166
NZ_CP029196.1\|WP_150159287.1\|849680_850121_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	8.96322e-05
NZ_CP029196.1\|WP_015031981.1\|857568_858117_-\|FABP-family-protein	gnl\|CDD\|378046	pfam08768, DUF1794, Domain of unknown function (DUF1794). This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.	3.28347e-57
NZ_CP029196.1\|WP_150163479.1\|851550_852606_-\|exo-alpha-sialidase	gnl\|CDD\|271234	cd15482, Sialidase_non-viral, Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.	3.61521e-80
NZ_CP029196.1\|WP_150159296.1\|855461_857564_-\|prolyl-oligopeptidase-family-serine-peptidase	gnl\|CDD\|224422	COG1505, COG1505, Serine proteases of the peptidase family S9A [Amino acid transport and metabolism].	0
NZ_CP029196.1\|WP_150159314.1\|871536_874461_+\|FAD-binding-protein	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.89192e-61
NZ_CP029196.1\|WP_150163480.1\|866804_867887_+\|NAD(P)-binding-protein	gnl\|CDD\|224983	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism].	1.32237e-37
NZ_CP029196.1\|WP_150159300.1\|861277_862138_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.0188e-104

>NZ_CP029196.1|WP_150159300.1|861277_862138_-|ATP-binding-cassette-domain-containing-protein
MQAGEETAATLRPPGHELSATGVTVAYEGVDVVHDAAMTLRPGEVTVLVGPNGSGKSTLLRTLARLQQPRTATLVLDGATDCLALSPREFSRHVALLTQGRPTPSGLTVRDLVEFGRYPYRGRWGKADPEGPAAVDRALALTGVTELAGRGAEHLSGGQLQRVWLAGCLAQQTGVLLLDEPTTYLDLRYQVELLDLMRDLADDHGIAVGAVLHDLDQAAAVADRIVLLDTGRVVADGSPSDVLTPERLTDTYGIRIEVDTDPLTGRLRTRAMGRHHSRSERLSPTS
>NZ_CP029196.1|WP_015031983.1|860303_861281_-|iron-siderophore-ABC-transporter-substrate-binding-protein
MRRLLLTTAAATTAALALTACGTTEPAADDAKKSTERITLTDATGTKVELDGPAKKVVGTEWNVVEHLIELGVDPVGVSDVKGYKTWDTAVPLKNEPKDIGTRGEPSMDTVAALKPDLILATSDLPPAAVKQLRKIAPVLEVKAADAADPIGRMTQNLDLIAKATGTTDKAAALKKQFEAKLAEGAKALADAKLAGAKYAFADGYVVSNQVSIRPYTSGSLIGAVNEKLGLKNAWTVKGDPAYGLGATDVEGLTKLGDVQFAYIGNDGDASSNPFAGVLAKDKVWTSLPFVKKGDVHRLPDGVWMFGGPGSMSKYVDSVVAALTK
>NZ_CP029196.1|WP_150159298.1|858232_860299_-|Fe(3+)-hydroxamate-ABC-transporter-permease-FhuB
MAVTATTPATRPPAATSRTGAAPVTAALLLLVAALAIVDLTQGTAAVGAPEVWKALTGRADPADASVVIASRLPRTAAGLLVGAVLGMAGAALQAVSRNVLASPDTLAVNAGSYFALSVVTVTGVSLPLIASSGVAFIGGLAAAAVVLGLSGLGTGTVRLVLAGSALTLGLTALTEGLLLLFPLQTDGIRHWNQGSIAQNGFDGVLQMLPIAVAGLVGLLLLARRIDALALGDDAARGLGVPVRATRLTAVVLAALLSTAAVTLAGPIGFVGLCAPALVRPLARRFRGFTRTRGGLPVAGLVGAALVLGSDVVLRVLVPSDVAVAVPTGVVTSLVGALFLVVMATRSRDTAGADAPDRLRIRGRGVFLATTAVLVVVLVGVVVAALLLGDAKLLLGDILNWAQGKAGRTTAFVLETRVPRVLAALLAGAALALAGTLVQAVTRNPLAEPGILGVSNGAALGAVLLVTTVPAAGSWGVAGAAFVGAAVSSVLVFGLAAKGGFRQNRLVLVGFGVATGASALISLLVILTDPFNAIKALTWLSGSTYGRTLPDVVPLAAVLTVGVVVAAARRTELDLVSLDEDTPRLLGLHLGRGRLGFLALAVLLSATAVAAAGTIGFVGLVAPHAARALVGRQHARVVPVAVLLGAVLVCTADLVGRTLIAPAQLGAGVMTAIVGTPYFLYLLVRTRR
>NZ_CP029196.1|WP_015031981.1|857568_858117_-|FABP-family-protein
MTDRERQHPYPDALRPDAAPAPHELLAPVTGLLGTWTGTGRGEYPTLAEDFTYAQEVTFSHDGRPFLHYEARAWLTGADGAPLRPAARESGWWRLKPEGLIEALITQPTGIAEIMVGRVEDGAVDLTTHTVALAPTAKHVEATRRRYTLTDGDTLDFVHDLAAVGQRLQHHLSARLRREDGK
>NZ_CP029196.1|WP_150159296.1|855461_857564_-|prolyl-oligopeptidase-family-serine-peptidase
MRNASEDDPYLWLEDISGEAALAWVAERNAETAGAVTADDGFGPLKARLREVLDASDRIPYTVRRGAYLYNFWRDAGHVRGLWRRTTLESYRQDEPDWEVLLDVDALAEAEGEKWVWDGANVRRPDFDRALVRLSRDGGDAVVVREFDLGTREFVADGFRLPEAKTRIGWAGPDTVLVGTDLGPDSLTDSGYPRTVRRWRRGTPVEASELVYEGERADVAAWGYRDSTPGFEREFVGRSPDFFRSETHLLRPDGTRVRIDVPDDADAYVHRQYLIVTLKSPWLGQPTGSLLAFGFDAFLAGDRTPEVLFTPDARTALAGHTWTRNHLILETMRDVSTRIEVLTPAAEGGWTREPLVGVPELSAVSVVDTDPDESDEYFLDVSGFLQPSTLRLGRIGAGTEVLKQAPHRFDTTGLTVGQHFATSADGTRVPYFVIGPDRTTTPGPGPALLYGYGGFEVSLTPSYAAVTGRAWLERGGTYVIANIRGGGEYGPDWHQAALGAERPRAFEDFAAVAKDLVARGITTPAMLGAKGGSNGGLLMGAMLTRHPELFGAIVAQVPLLDMTRFHKLLAGASWIAEYGDPDDPADRPHLAAISPYHQLAADRPYPPVLLMTSTRDDRVHPGHARKTAARLRELGHRVLFYENTGGGHAGAGDNEQAAHNSALVHTYLWQQLAAPGSPTVPGPLTASPSAVPAAPSGTGS
>NZ_CP029196.1|WP_150159294.1|854530_855514_+|helix-turn-helix-transcriptional-regulator
MANERLGEALRLLGIGPEAVRVYRSLLELGPAPLADVGAAAGLAGAELAAAYGELVGSGLASAAEAGRDTVAPVPPAAGLEILGRRRAAELDESRITVGGAFDAFRRQRLTGYQDPLVEVVTGDAIGLRMRQAWTSAREQIRQLDSPPYFPLDGATDDALATLARGVTQRVVYSRESLEHPGQLENSIEPCIEAGEQARVLPSVPVKLVIIDDAYALVALSIRETDVYNTMLVVQPCGLLSALVALFEQAWQNALPFHGRSARPAGLLPADRRLLRLLAAGAGDEVIARELGVSRRTLFRRVQVLMARLGATSRFQMALQAQRSGWL
>NZ_CP029196.1|WP_150159292.1|852969_854382_-|M24-family-metallopeptidase
MAKGRKNGLYEGVSEELSRLMRTGWADSERRGTEPAEQAPYAAARRAALSARFPGERLVIPSGNLKTRSNDDTYPFRPYTGYVHMTGDQARDGALVLEPRADGGHDAYCYQLPRDSRENDEFWIGYTAELWMGRRRTLAESEILLGLPCRDVRGAAADLAAVTGVPTRIVRGHDPALEAAVGTDEDRDDELEEALSELRLVKDAWELGEMRKAVDSTVRGFTDCVGELSRAVASSERWIEGTFFRRARLEGNAVGYGSICAAGEHATIMHWTDNDGPVRPGELLLLDAGVETHSLYTADVTRTLPISGTFTPVQRQVYDAVYEAQEAGMAAVKPGAPYRDFHEASQRHLTARLVEWGFIEGPVDRAYALGLQRRFTMAGTGHMLGLDVHDCAQARTAEYVDGVLEPGMVLTVEPGLYFQPDDLTVPEEWRGIGVRIEDDLVVTEDGHENLSAGLPRSSSEVEAWMAEFAG
>NZ_CP029196.1|WP_150163479.1|851550_852606_-|exo-alpha-sialidase
MRTPAGTVLAFAEGRAAGGGDSGAIDIVVRRSEDGGCTWEPQRIAADGRGDTRGNPAPVVDPRTGDVVLVSSFNGAEATESRILAGQVPAARGRRVFVQRSADDGRTFSAPREITAQVKRPGWRWYATGPGHAVALRHGPHAGRLVVPANHSAAPPEGSADTGREPRYYGAHALYSDDGGRSWRLGFVDDTYDGQVNANESAVAELPDGRLYFSARDQLGNGPGNRADTTSGDGGLSIERPFAPQPALDAVPVVQGSLLYVGGPGGTLLFSAPSVPDARVAPALWSSRDGGLTFTRTLTVSGRKGAYSDLVQLDGETIGLLHETGTKSPYETLEFRRVPLAAVTGPGGGPA
>NZ_CP029196.1|WP_150159290.1|850212_851493_-|DUF418-domain-containing-protein
MTLSAAAEPGADDGPAGRAGSAGGAGGAGEGGGGRPGARLAQVDALRGFALLGILLVNIGFQASAYHGVGLAEPGFDSPLDGAVRWFVALFFESKFFLLFSFLFGYSFTLQPASAERDGVRFAPRFLRRLTGLFVLGVLHAVLLFSGDILTTYALLGLILFAARRVRPRAAVRTAVILLTVTASLYLLLAAGVFLMGGADVPDAGAAAEAERAAQALRGGPGSVIGQHLAELSEFVFALIFLQAPASLAAFFLGLAAGRARALGDLARHRATLVRLQWAGFTVGLLGAGVYAWGNLADAGDAFQILAIGIDLLTAPLLSAAYGATVLRLTQGRFGRRTVALLGPVGSMTLTGYLTQSLVCALLFTGYGAGLVGRVPPAGVLAIALALFAAQVVASRWWLRRYRSGPVEWALRAWTTLSVPPLRREA
>NZ_CP029196.1|WP_150159287.1|849680_850121_-|nuclear-transport-factor-2-family-protein
MHPFRKAVEAMDHAAVEALLAEDVVFTSPVAFRPYPGKAITAAILRAVMRVFSDFRYVREIASADGRDHALVFTAKVGDMEINGCDFLHMDEEGKIDDFMVMVRPLSAAQALSAAMGAQFDRVKAEAFGGAEAPAESAGTPADGER
>NZ_CP029196.1|WP_041663616.1|862892_863714_+|ABC-transporter-permease
MSPLPDVEALTPDRGAGRGLTVPRWLRRTVGPVLLLALWQTLSATGVLPADALASPGTIARAGAELIGDGTLPTAMGVSLRRVAAGLLIGGVVGIALALLSGLSRLGEDLVDAPVQMLRTVPWVGLIPLLIIWLGIGEAPKVALIALGVAFHLYLNVYAGIRGVDAQLVEAGRSLGLGRRGLVRHVVLPGALPGAMTGLRYSLATAWLALVFGESINADAGIGFLMNQAREFFRTDVIVVCLVVYAFLGLLADALVRTLERLLLQWRPTFTGQ
>NZ_CP029196.1|WP_041662061.1|863686_864418_+|ABC-transporter-ATP-binding-protein
MATDLHRAVTVRGLTRSFDGRPVVDGLDLTLAAGQFTALLGHSGCGKSTLLRVLAGLDREISGTVLVPRRRAVAFQAPRLMPWKRVWRNVLLGLPGKPGRAVAERALEEVGLSHRSGAWPKTLSGGEAQRASLARALVRDPDLLLLDEPFGALDALTRIKAQRLVAELWRRRGCTVLLVTHDVDEALLLADRVLVMRDGVIAYDTAVDLDRPRSPGDPALAALRTRLLAELGVAEGEFAEKAA
>NZ_CP029196.1|WP_150159304.1|864421_865489_+|aliphatic-sulfonate-ABC-transporter-substrate-binding-protein
MRPHLLRGDLSVKRLRLSAAALLLPLALLASACSGVSAAGQTSNTDGKGSLVLNVGDQKGGAEALLRAAGELDDLPYRIAWSTFTSGPPLLEAVNAKAVDIGSVGNTPPVFAAAAGSKITVVSATHGDSAGEAILVAADSPVRTVGDLKGRKVAVAQGSSAHFQLIASLAKAGLKPADVRVTLLQPADALAAFTSGKVDAWAAWDPYTSQVLLSGKGRVLTDGRGLVNGLGFQVAAPSALADPAKAKAVGDFVERLRRAQGWVFDHPEEWAKVWAKETGLPYEVALAAVKRSNGTRIPVALDDAAVASEQKIADTFAALGLVPRTIRFADFVDTRFNKDLPPSTTPARSYGKASS
>NZ_CP029196.1|WP_150159306.1|865485_866697_+|LLM-class-flavin-dependent-oxidoreductase
MTVHLHWFLPTGGDGRTLVDRHAYTDGGITRDRAVSGVRAPDIDYLTQIAKAAEQLGFEAVLTPTGTWCEDAWLTTVALAQHTERLKFLVAFRPGVISPVLAAQMASTYQRITRGRLLLNVVTGGDSAEQRRFGDHLDHDLRYARTSEFLSVVRGVWGGRPFDHEGEHFRIEGGLTALPPDPLPEIFFGGSSAAAGPVAAEHADVYLTWGEPPWQVKEKIDWIRGLAEERGRTVRFGVRLHTISRDSAREAWATADRLLSDLDAETVAAAQRVLGRSESVGQQRMLALHRGGSLGRDELEIAPNLWAGVGLVRGGAGTALVGSHAEVADRIEEYHDLGVEYFVLSGYPHLEEAYWFGEGVRPELAARGLLPDSVPSPLLGVPAANGRPASAPGGAPLLVAGGR
>NZ_CP029196.1|WP_150163480.1|866804_867887_+|NAD(P)-binding-protein
MDVVVIGAGQAGLSAAFHLRRAGLEPDRDFVVLDHAPRPGGAWQFRWPSLTYGKVHGMHALPGMELTGADPARPSSEVIGGYFDTYEQTFDLRVHRPVDVTAVREGEGGRLLVETSAGDYATRALVNATGTWDRPFWPRYPGQETFRGRQLHTAGYPGPAGFAGKRVLVVGGGASGTQHLMEIADVAAETFWVTRREPVFREGPFGEMEGRAAVALVEERVRRGLPPQSVVSVTGLPLNDAIRAARAQGVLDRLPMFDRITPTGVAWDDGRSVDVDVILWATGFRAAIDHLAPLRLREPGGGIRVEGTRAVRDERVHLVGYGPSASTIGANRAGRVAVSDIRRLLRHGPAAAPAAGVVTV
>NZ_CP029196.1|WP_150159308.1|867893_868751_-|endolytic-transglycosylase-MltG
MTYRPPSPYAPPRRRPRLTRRGRLALLVGAALAVAVAIAVPLHLTRDEPAVEKPRMLLVPEGWRAGQVYTAVDRMLGLPEGTARKAATAPGTHLPLPAAAGGNPEGYLFPATYPVLDATTPDALLRFMVDTAGKRFGAARIAQGARAHGMSVYETVTAASIVQAEADNPEDMAKVARVVHNRLARGMALQMDSTLNYALGRSTVDTSYEDTRTASPYNTYERKGLPPTPIGNPGDEALDAVIRPADGDWLYFVTVAPGDTRFTADYAAHQQNVAEFNANRSAAKS
>NZ_CP029196.1|WP_150159310.1|869057_870917_-|ATP-binding-cassette-domain-containing-protein
MRPHDQSDWTPPPRDPRQPKEPAQLRRILRLFRPYRARLLLVGLLVGAASLVTVASPFLLKEILDTAIPQGRTGLLSLLALGMIATAVLTSVFGVLQTLISTTVGQRVMHDLRTGVYEQLQRMPLAFFTRTRTGEVQSRIANDIGGMQATVTSTATSLVSNLTAVVATVAAMLALEWRLTLVSLLLLPVFVWISRRVGNERKRITTQRQKQMAAMAATVTESLSVSGILLGRTMGRADSLTKSFAEESERLVDLEVRSSMAGRWRMSTIGIVMAAMPALIYWAAGIALGAGGAAISLGTLVAFVSLQQGLFRPAVSLLSTGVQMQTSLALFQRIFEYLDLPVDITEPDEPVRLPVIRGEVAFEKVEFRYDPQGTGRPTLDAVDLTVPAGGSLAVVGPTGSGKSTLSYLVPRLYDVTGGRVTLDGVDVRDLDFDTLARAVGVVSQETYLFHASVADNLRFAKPDATDEEIEAAARAAQIHEHIASLPEGYDTLVGERGYRFSGGEKQRLAIARTILRDPPVLILDEATSALDTRTEHAVQQAIDALSAGRTTITIAHRLSTVRDADQIVVLEAGRIAERGTHEELLARDGRYAALVRRDARTAASATEQANVGAVVPQNV
>NZ_CP029196.1|WP_150159312.1|871007_871496_+|MarR-family-transcriptional-regulator
MSTSAVPTGPGRSGEPDTEGADGLLAEQLLRLTRRLHRIQKRHLEPVGITPAQSRLLRTVAHFGEPPRMADLAARLEVVPRAVTSLVDGLEAVDRVRRVPDPHNRRVVRIELTDAGRATLRELRSARRAAAEDILAPLTAAQREELGGLLTALVDPGPEAGC
>NZ_CP029196.1|WP_150159314.1|871536_874461_+|FAD-binding-protein
MLLFEPNPQSLRPGTKRTPAPDRVPELQARGTPRRLREELTELLGPGKVLSTISDLVRYASDASPYRFVPQVVVVAEDIDDISTVLSYAHGKGREVVFRAAGTSLNGQAQGEDILVDVRRHWAGVEVLDGGTRARIRPGTTVVRANAALAPYGRVLGPDPASAIACTIGGVVANNASGMTAGTTRNSYRTVSSLTFVLPSGTVVDTADPAADEELAHAEPRLCAELMRLKAEIEADRELTDRIRAKYAIKNTNGYRLDAFLDGDTPVRILRGLMVGSEGTFGFISEVVFDTLPLDREVSSALLFFPSLPAAAEAVPRFNDAGALAVELMDGNTLRASVSVAGVPADWAELPKETAALLVEFRAPDAEARAAYERAARKVLDGLDLVAPVPSVENAFTTDPGRIAGYWKARKAFVTAVGGSRPSGTTLITEDFAVPPARLAEACEALLDLQSRHGFDAAVAGHAAHGNLHFLLAFDAGDPADVERYAAFMAEFCKLTVERFDGSLKAEHATGRNIAPFLELEWGTKATDLMWRVKEAVDPDGVLAPRIVLDRDPYAHLRGLKTIPTVERIADPCIECGFCEPTCPSQDLTTTPRQRIVLRREMMRQNDGSAVETRLLESYGYDAVDTCAGDSTCKLACPVGIDTGALMKEFRHERHTPGQERVAALAAKNFRAAEASARLAVAAADRIGDRVLESVTGLARRAVSTDLVPEWLPEIPGAAARRLPRTHRPAAVAVYYPACVNRIFGGPDGGRGPSLPEAVVAVSARAGKPVWIPDDVAGTCCATIWHSKGYERGNEVMANRIVEAAWGWTAGGTLPLVVDASSCTLGIAHEVVPYLTEDNRALHAELTVLDSLVWAADELLPRLDVRRRVDSAVVHPTCSMRHLGDEEKLTELARACADEVVVPVDAGCCAFAGDRGMLHPELTASATAREAAEVTARPFDAHLSANRMCEIGMDRATGRGYGSVLLALERATRP
>NZ_CP029196.1|WP_150159316.1|874693_876109_+|Gfo/Idh/MocA-family-oxidoreductase
MNEQSPHTPSRRKVLRTTAAAAGTGLGIGALGSVTAEAAAAAPAEAPSTAAAAPRRKGATMAGVPFAGRSTVRVGLIGLGNRGASMIGLYLALPWVRVVAVCDPVREKAERAAAKVVAAGQPAPAVYTHGEDDYENLCARSDVDFVHVATPWDSHFPIARAAMLAGKHVGVECPVAMRLDELWELVDLSEQTRRHCMQLENCCYGRNEMRVLRMAHAGKFGRLLHGAGAYNHDLRALMFSPTYYEGPWRRRWHTQLRGDLYPNHGFGPVANYMDVNRGDRAVSISSFGTPALGLAEYREEHMPPGDPSWKESYIGSDRTISLVQTAKGRVIRLEHDVSTPHPYSRINSLGGTRGVFEDYPERIYLEPDHKDDRWGDFAAYAGEFDHWLWKEHANPPGGHGGMDYIMVYRLMQCMQLGLPPDFDVYDAATWTAPVPLSNASIKANGAPQEIPDFTRGEWRKARSGVDSVKPA

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Crispr_ID: NZ_CP029196_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_3

1564195-1565013

Orphan

Consensus_repeat	Method
CGGTCGTCNCGNCGGAAG	CRT

11 spacers

The CRISPR arrays of NZ_CP029196_3

>merge|NZ_CP029196|3|1564195-1565013|CRT
CGGTCGCTGCGCTCGCGGTCGTCGCGGCCACGGTAGCCACCGCGGTCTCCGCCCCGGTCGTCGCGGCCGCGGTACCCACCACGGTCGCCGCCCCGGTCGTCCCGGCCACGGTATCCGCCGCCACGGTTGTCGCCACCACGGTCGTCACGGCGGAAGCCGCCGCCACCGCGGTTGTCGTCACGGCGGAACGACGAGGGACGCTCGTCACGGCGGTCGTCGCGGCGGAAGCCACCACCGCGGTTGTCGCCACCACGGTCGTCACGGGGGAAGGAGGGCCGGTCGTCCCGGCGGAACGACGACGGACGCTCGTCACGCCGGTCGTCACGGCGGAAGCCACCGCCACGGTTGTCATCACGACGGTCGTCGCGGAACGACGGCCGGTCGTCCCGACGGAACGAAGGACGCTCGTCACGCCGGTCGTCACGGCGGAACCCGCCGCCACGGTTGTCGCCACCACGGTTGTCGTCGCGGCGGTCGTCACGACGGAACCCGCCACGGTCGCCACCACGGCTGTCGCCACCACGGTCGTCGCGACGGAACCCACCACGGTCGCCGCCACGGTCGTCACGCGGGAACGAAGGCCGGTCGTCACGGCGGAAGCCACCGCCACGGTTGTCGCCACCACGGTCGTCGCGACGGAAGCCGCCGCCACCACGGTTGTCGTCACGGCGGAACGACGAGGGACGCTCGTCACGCCGGTCGTCACGGCGGAAGCCACCACCGCGGTTGTCGCCACCACGGTCGTCACGGGGGAAGGAGGGCCGGTCGTCACGACGGAAGGACGACGGACGCTCGTCACGCCGGTCGTCACGGCGGAAG

>NZ_CP029196|3|2|1564195-1565013|CRT
CGGTCGCTGCGCTCGCGG	TCGTCGCGGCCACGGTAGCCACCGCGGTCTCCGCCC
CGGTCGTCGCGGCCGCGG	TACCCACCACGGTCGCCGCCCCGGTCGTCCCGGCCACGGTATCCGCCGCCACGGTTGTCGCCACCA
CGGTCGTCACGGCGGAAG	CCGCCGCCACCGCGGTTGTCGTCACGGCGGAACGACGAGGGA
CGCTCGTCACGGCGGTCG	TCGCGGCGGAAGCCACCACCGCGGTTGTCGCCACCA
CGGTCGTCACGGGGGAAG	GAGGGCCGGTCGTCCCGGCGGAACGACGACGGACGCTCGTCACGC
CGGTCGTCACGGCGGAAG	CCACCGCCACGGTTGTCATCACGACGGTCGTCGCGGAACGACGGC
CGGTCGTCCCGACGGAAC	GAAGGACGCTCGTCACGCCGGTCGTCACGGCGGAACCCGCCGCCACGGTTGTCGCCACCACGGTTGTCGTCGCGG
CGGTCGTCACGACGGAAC	CCGCCACGGTCGCCACCACGGCTGTCGCCACCA
CGGTCGTCGCGACGGAAC	CCACCACGGTCGCCGCCACGGTCGTCACGCGGGAACGAAGGCCGGTCGTCACGGCGGAAGCCACCGCCACGGTTGTCGCCACCA
CGGTCGTCGCGACGGAAG	CCGCCGCCACCACGGTTGTCGTCACGGCGGAACGACGAGGGACGCTCGTCACGC
CGGTCGTCACGGCGGAAG	CCACCACCGCGGTTGTCGCCACCACGGTCGTCACGGGGGAAGGAGGGCCGGTCGTCACGACGGAAGGACGACGGACGCTCGTCACGC
CGGTCGTCACGGCGGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150159933.1\|1572817_1573357_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NZ_CP029196.1\|WP_150159932.1\|1571981_1572764_+\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_CP029196.1\|WP_150163514.1\|1559270_1559531_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150159931.1\|1571231_1571894_-\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|234840
NZ_CP029196.1\|WP_015032638.1\|1574960_1575899_-\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407
NZ_CP029196.1\|WP_150159925.1\|1555639_1557382_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP029196.1\|WP_150159934.1\|1573524_1574031_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|224321
NZ_CP029196.1\|WP_015032640.1\|1576495_1577293_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP029196.1\|WP_150159936.1\|1575992_1576421_-\|NfeD-family-protein	unknown	unknown	gnl\|CDD\|376684
NZ_CP029196.1\|WP_150159935.1\|1574094_1574862_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|376667
NZ_CP029196.1\|WP_015032624.1\|1557527_1558451_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|235121
NZ_CP029196.1\|WP_150159927.1\|1559951_1560794_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP029196.1\|WP_150159930.1\|1570798_1571098_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150159924.1\|1554857_1555643_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150159929.1\|1562017_1563310_+\|DUF1015-family-protein	unknown	unknown	gnl\|CDD\|377633
NZ_CP029196.1\|WP_150159926.1\|1559598_1559946_+\|sterol-binding-protein	unknown	unknown	gnl\|CDD\|379708
NZ_CP029196.1\|WP_150159928.1\|1560846_1561938_-\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|319832
NZ_CP029196.1\|WP_150159937.1\|1577449_1578241_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_015032625.1\|1558447_1559263_-\|TlyA-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|224110
NZ_CP029196.1\|WP_150163515.1\|1563377_1564118_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|371058

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150159933.1\|1572817_1573357_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	2.51625e-58
NZ_CP029196.1\|WP_150159932.1\|1571981_1572764_+\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	1.31318e-107
NZ_CP029196.1\|WP_150159931.1\|1571231_1571894_-\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|234840	PRK00802, PRK00802, DNA-3-methyladenine glycosylase.	8.72008e-88
NZ_CP029196.1\|WP_015032638.1\|1574960_1575899_-\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	8.31127e-67
NZ_CP029196.1\|WP_150159925.1\|1555639_1557382_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0
NZ_CP029196.1\|WP_150159934.1\|1573524_1574031_+\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	4.42811e-18
NZ_CP029196.1\|WP_015032640.1\|1576495_1577293_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	7.52999e-92
NZ_CP029196.1\|WP_150159936.1\|1575992_1576421_-\|NfeD-family-protein	gnl\|CDD\|376684	pfam01957, NfeD, NfeD-like C-terminal, partner-binding. NfeD-like proteins are widely distributed throughout prokaryotes and are frequently associated with genes encoding stomatin-like proteins (slipins). There appear to be three major groups: an ancestral group with only an N-terminal serine protease domain and this C-terminal beta sheet-rich domain which is structurally very similar to the OB-fold domain, associated with its neighboring slipin cluster; a second major group with an additional middle, membrane-spanning domain, associated in some species with eoslipin and in others with yqfA; a final 'artificial' group which unites truncated forms lacking the protease region and associated with their ancestral gene partner, either yqfA or eoslipin. This NefD, C-terminal, domain appears to be the major one for relating to the associated protein. NfeD homologs are clearly reliant on their conserved gene neighbor which is assumed to be necessary for function, either through direct physical interaction or by functioning in the same pathway, possibly involve with lipid-rafts.	5.02961e-16
NZ_CP029196.1\|WP_150159935.1\|1574094_1574862_-\|TSUP-family-transporter	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.43522e-23
NZ_CP029196.1\|WP_015032624.1\|1557527_1558451_-\|NAD-kinase	gnl\|CDD\|235121	PRK03372, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	8.22742e-167
NZ_CP029196.1\|WP_150159927.1\|1559951_1560794_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.29338e-134
NZ_CP029196.1\|WP_150159929.1\|1562017_1563310_+\|DUF1015-family-protein	gnl\|CDD\|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	2.36459e-124
NZ_CP029196.1\|WP_150159926.1\|1559598_1559946_+\|sterol-binding-protein	gnl\|CDD\|379708	pfam14864, Alkyl_sulf_C, Alkyl sulfatase C-terminal. This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates.	6.96579e-05
NZ_CP029196.1\|WP_150159928.1\|1560846_1561938_-\|HAD-hydrolase-like-protein	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.53719e-91
NZ_CP029196.1\|WP_015032625.1\|1558447_1559263_-\|TlyA-family-RNA-methyltransferase	gnl\|CDD\|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	3.77854e-103
NZ_CP029196.1\|WP_150163515.1\|1563377_1564118_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|371058	pfam10446, DUF2457, Protein of unknown function (DUF2457). This is a family of uncharacterized proteins.	0.000379893

>NZ_CP029196.1|WP_150163515.1|1563377_1564118_-|tetratricopeptide-repeat-protein
MSLPKGLAEDVSRNLVMVAQLIDEDPEKAYGYSRVALRLASRVAAVREAAGFAAYATQKYSEALAEFRAARRMSGGVELWPVMADCERGLGRPERALAMAGEPEVQKLDKAGQVEMRLVAAGARRDMDQLDAAIVTLQSPELASSAVHPWTARLRYAYADALLAAGREREAREWFAKALEADKDGATDASDRLAEMDGVEFVDAFVEDEADEDESGLVVEGDLDDDLDEDDEDEDDDLGRGDGDKS
>NZ_CP029196.1|WP_150159929.1|1562017_1563310_+|DUF1015-family-protein
MNTSGHAAADVRDDTVGLHLTPFRGLRYVPERVGSLAAVTSPPYDVVVRPDGLLHLESADPHNIVRLILPQAITAGTRHRKAAVTLDRWLADGVLAPDPEPALYVYEQHGDGILQRGIIGALELTTPAEGVVLPHEDVMPHVVEDRAALMRTTAANLEPLLLTYVGDGDGAGRVVERTVQRPPLLATTTEDGFHHRLWAVTDPAEQAAVTAELGRHQALIADGHHRWATYLRLREEHPSPGPWNYGLVLLIDTARYPLRVRAIHRLLNRLPLADALTALDGSFRVRRIERPLPAALDALAEATAEGNAFLLAGDGGFHLVDRPDPALLDRTIRTDRPDAWRTLDATVLHSTLLEHVWQIPDAPEDISYIHDTEAAVAQAERRGGTAVLMHPVREDVVRDLARQGVTMPRKSTSFGPKPATGLVLRSLALD
>NZ_CP029196.1|WP_150159928.1|1560846_1561938_-|HAD-hydrolase-like-protein
MTVRNGQGRRGVGRTRPGGSAVPLSEAYDTALLDLDGVVYAGGEAVPHAVEALGAARAGGMHLAYVTNNALRTPDAVAEHLTELGVPAEAGDVITSAQAVARLIADDVPPGSRVLVIGGEGLRVALRERGLVPVDSAEDGPVAVVQGYGGPEMPWGRFAEASYAVARGLPWYASNTDLTIPGARGIGPGNGAAVEVVRIATGGRVEPKVAGKPLPPMHRETVLRTGAKRPLVVGDRLDTDIEGAFNGGVDSLLVFTGVTDAAQLLAAVPEHRPTYVAADLRGLLVGQPEVVAGEGGVFVCGAWRASVSAPDGGELVLEGPAGDAAGADPMDGVRALCGAAWSAADAAGGAVPDGGKVLARLGF
>NZ_CP029196.1|WP_150159927.1|1559951_1560794_-|ATP-binding-cassette-domain-containing-protein
MDGRQQRLSAESVTLAYEQRVIARDLSVEIPDNSFTVIVGPNACGKSTLLRALSRMLKPSQGRVLLDGQSIHALPARKVAKTLGLLPQTSVAPDGITVADLVARGRYPHQGLLRQWSPEDERITRESMAATGVAELAGRYVDELSGGQRQRVWIAMALAQQTPLLLLDEPTTYLDIQHQIDVLDLCAELHETQGRTLVAVLHDLNHAARYATHLIAVRDGEVVAEGPPADVVTAELVERVFGLRCQVIEDPETGTPLVVPAGRKARVPRPAASPEPALRK
>NZ_CP029196.1|WP_150159926.1|1559598_1559946_+|sterol-binding-protein
MATITECRDALDRLSDNLARADGDVRGAAALDRTLSCHITDLDSTFTGRLAGGRIEVESLVAGPPPAKAQIRLAMTGDDLVAMVGGELNFAKAWASGRVRLEAGFRDLLRLRSLL
>NZ_CP029196.1|WP_150163514.1|1559270_1559531_-|hypothetical-protein
MDATPEAEAEAPRGGADEPAAAAPLEVVRELTGHPGVDVHLARLDEVDHLPADGHLEVYEDVHRGLRAELTSLDAHPAPRPHDNRS
>NZ_CP029196.1|WP_015032625.1|1558447_1559263_-|TlyA-family-RNA-methyltransferase
MAGVARRRLDAELVRRKLARSREHASQLIAAGRVTVGKTVATKPATQVETAAAIVVVQDDSDPDYVSRGGHKLAGAFEAFVPLGLKVEGRRALDAGASTGGFTDVLLRAGAAHVVAVDVGYGQLAWSLQSDERVTVKDRTNVRELTLDAIDGVPVDLVVGDLSFIPLGLVLPALAACTAPDADLVLMVKPQFEVGKERLGTGGVVRSAELRADAVKNVARRAAELGLGVLGVTASPLPGPSGNVEYFLWLRAGAPALDPADVDRAVAEGPR
>NZ_CP029196.1|WP_015032624.1|1557527_1558451_-|NAD-kinase
MSSTAAAPETAPRTVFLLAHTGRPAAVRSAELVVLGLLRCGIGVRVLEAEAEDLPLPPAVERVKEACSDALDGCELLVVLGGDGTLLRGAEFSRASGVPMLGVNLGRVGFLAEAERDDLDKVVDRVVTKAYEVEERMTLDVVVYENGDVLHRDWALNEAAVQKVSPERMLEVVLAIDGRPVTGFGCDGVICATPTGSTAYAFSAGGPVVWPEVEALLMVPIGAHALFAKPLITTPESVLAVEVEPHTPHGVLWCDGRRTVELPAGARVEVRRGAVPVRLARLHHASFTDRLVAKFALPVSGWRGGAR
>NZ_CP029196.1|WP_150159925.1|1555639_1557382_-|DNA-repair-protein-RecN
MVWGVLEEMRIRSLGVIDDAVVELSPGFTAVTGETGAGKTMVVTSLGLLLGGRADPALVRIGAASAVVEGRISVPAGAPAALRAEEAGAELDDGVLLVSRTVSAEGRSRAHLGGRSVPVGLLAELADELVAVHGQTDQQGLLKPARQRGALDRYAGEAVSVPLAAYAEAYRRLRAVSGELDEITTRARERAQEADLLRFGLGEIEAVAPRAGEDTELAAEAERLGHAEALASAAALAHAALAGVPEDPESVDATTLVAGAGRALESVRSHDPALAALADRMGEISILLGDVATELAGYADDLDADPLRLAAVEERRAALTQLTRKYGEDIASVLAWAEESAGRLGELDGDDDRVEELTAERDRLRDELSVLAQRLTDARTEAADRFADAVTAELASLAMPHARVSFDIRQTEDPDGVEVGGRRVAYGPSGADEVELLLAPHPGAPPRPIAKGASGGELSRVMLAVEVVFAGVDPVPTYLFDEVDAGVGGKAAVEIGRRLAKLAKTAQVVVVTHLPQVAAFADRQLLVEKTNDGSVTRSGVTVLEGEERVRELSRMLAGQEDSETARAHAEELLATARADG
>NZ_CP029196.1|WP_150159924.1|1554857_1555643_-|hypothetical-protein
MRGRLVSFGVAAVVSRAVYGALRGRVAGGGVSPAAGESGSPMDRGSVSQGPWTRVNHGGRVVDLCAGPAVALGAAVGAGSGPVAFAVLAAGACGAYDDVKGDSRRGFRAHLTVLRDGEVTSGAVKLFGIGAASLVAGALLKERAVDKVLAGVVIAGTAHLVNLVDVRPGRAGLAVLALGAPGLPRGASAAAPMGAVTAVLGDDLGERTMLGDTGAHALGAAVGCAIAAANGRLGLAVHAAGLIAAAAWGERETASRAHPSG
>NZ_CP029196.1|WP_150159930.1|1570798_1571098_+|hypothetical-protein
MYVAYPPQGPVGLSKEPRHPKMDGVSTNLALIFGTLLSSQGTDASFVLTLSGFPPDFSLRVSNLTRSFSVPFPVRSLYPVACWLPFASRRVHYFSRFPR
>NZ_CP029196.1|WP_150159931.1|1571231_1571894_-|DNA-3-methyladenine-glycosylase
MSESPDRTPLPRAFFDRPVLEVAPDLLGRTLVRRSPEGVMELRLTEVEAYAGAIDPGSHAFRGRTVRNAVMFGPPGHAYVYFTYGMWHCLNLVCGPEGKASGVLLRAGEILKGAEQARPRRRSARRDHELAKGPARLATALDIALSLNGTDTCDGPDSPLAVLTGTPPRARNIRSGPRTGVGGDGAPHPWRFWIDEDPTVSPYRPHTPRKRPLDSDRPTA
>NZ_CP029196.1|WP_150159932.1|1571981_1572764_+|sporulation-protein
MGFKKLLASLGAGGASVETVLTEENVVPGGVVQGEVRIQGGSVDQQIEGLSVGLQARVEVEGGDQEHKQDIEFVKVRLGGAFEVKAGAVHVVPFGLEIPWETPVTAVSGQQLRGMHIGVTTELEIARAVDSGDLDPVNVHPLPAQQAILDAFLQLGFRFKSADMERGHIRGTRQKLPFYQEIEFFAPQQYRGLNQVEVSFVADDREMDVVLEMDKKPGLFGEGSDSFRAFKVGLHDFHTTDWAAYLNQWLAEVGGRRNWL
>NZ_CP029196.1|WP_150159933.1|1572817_1573357_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MSEGKRAPLPHDFHPPVAAFTVVSDDIAPGGVLKDAQVYAAGNTSPQLRWEGFPAGTKSFAVTCFDPDAPTGSGFWHWVLFDIPASVTELPAGAGSGSFEGLPAGAVHVRNDYGSKDFGGAAPPAGDPAHRYVFTVYAVDSEKLGPDSDASPAAIGFNLRFHTLGRAQLIGEYAAPAAG
>NZ_CP029196.1|WP_150159934.1|1573524_1574031_+|HNH-endonuclease
MRDTLVLNASFEPLSTVTLNRAVVLVLTDKAVVEHAHPDLRVRGAAVDLPVPRVIRLCRYVRVPFRRQAPWSRRGVLVRDQHRCAYCGRRATTVDHVVPRAQGGGDSWLNTVASCAEDNHRKADRTPEQAGMPLLHQPFEPTPADAMLLAMRASERSELPEWLARAAA
>NZ_CP029196.1|WP_150159935.1|1574094_1574862_-|TSUP-family-transporter
MSIWEALAVLAAGIGAGTINTIVGSGTLITFPVLLATGLPPITANVSNALGLVPGSISGAIGYRAELKGQKRRILRLGGAALLGGLIGAILLLALPSDAFDAIVPILIGLALVLVLLQPRIAAAVKRRREQTGTEAHPDGGPVLLGGLFLASMYGGYFGAAQGVLYLSLMGLLLHDNLQRINAVKNILGALVNGVAAVFFLFVADFDWTAVLLIAVGSTIGGQIGAKVGRKLPPTVLRGVIIAVGIIAILQLTLR
>NZ_CP029196.1|WP_015032638.1|1574960_1575899_-|SPFH/Band-7/PHB-domain-protein
MSAVIIVLIILVVLVFIALIKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDSIRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRAERDKRAAILTAEGTRQSAILTAEGEKQSAILRAEGESKAAALRAEGEAQAVRTVFEAIHAGDPDQKLLSYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLSGAFGNKDGSVPGFNTKAAGTERRDEPPVD
>NZ_CP029196.1|WP_150159936.1|1575992_1576421_-|NfeD-family-protein
MDIDAWVWWLIGAVGLGIPLVLTAMPEFGMFSVGAVAGAVTAALGFGVVPQVLVFVVVSVALIAVVRPIAARHRDDRPRHATGIDALKGRQAVVLERVDVHGGRIKLAGEIWSARTLDTGQSFEPGEQVDVVDIDGATAVVM
>NZ_CP029196.1|WP_015032640.1|1576495_1577293_-|ABC-transporter-ATP-binding-protein
MSDVLELVDVSVVRDGRALVDEVSWSVKEGERWVILGPNGAGKTTLLNIASSYLFPTKGTAHILGERLGGVGTDVFELRPRIGMAGIAMAEKLPKRQTVLQTVLTAAYGMTATWHEDYDPVDEQRAKAFLDRLGMNDYLDRKFGTLSEGERKRTLIARAMMTDPELLLLDEPAAGLDLGGREDLVRRLGRLARDPYAPSMIMVTHHVEEIAPGFTHVLMIRQGKVLAAGPVEMELTSRNLSHCFGLPLVVERVGDRWTAHGLPLK
>NZ_CP029196.1|WP_150159937.1|1577449_1578241_+|hypothetical-protein
MLSEPRSGRLAAWGNALLAGAVSPDEAALAIVGEDAVHRVEGLPGEARPVGLTLALGRLRRLGVTGWRVALPAPGHPLGLSGPPDFNARALEAEEAAVGFGAPYGLVPEVSEAGPPGDVHVEVVWRCLAVREAPPADVPSLGEAERELAEALRDATAVLTRLDVAASGPTADAAREAYRARAEVGREVLAPGYPPRAVRVLELAQRIGLLVDLAYDHGHGGAVSAAEMAARSEALRPVERVARRAQVAAYNAYVEERERERGF

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Crispr_ID: NZ_CP029196_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_4

2201683-2201753

Orphan

Consensus_repeat	Method
CCGGAACCCGGCCGGAAGCGGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_4

>merge|NZ_CP029196|4|2201683-2201753|CRISPRCasFinder
CCGGAACCCGGCCGGAAGCGGAACCCGGCCGGAAGCGACCCGGCGGCACCGGAACCCGGCCGGAACCGGAA

>NZ_CP029196|4|2|2201683-2201753|CRISPRCasFinder
CCGGAACCCGGCCGGAAGCGGAA	CCCGGCCGGAAGCGACCCGGCGGCA
CCGGAACCCGGCCGGAACCGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150160259.1\|2195529_2197230_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP029196.1\|WP_150160264.1\|2203701_2204031_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NZ_CP029196.1\|WP_150160257.1\|2193743_2194424_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160258.1\|2194420_2195533_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	unknown	unknown	gnl\|CDD\|223692
NZ_CP029196.1\|WP_015033250.1\|2198393_2198795_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|366654
NZ_CP029196.1\|WP_015033260.1\|2209055_2209724_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319829
NZ_CP029196.1\|WP_150160262.1\|2201778_2202876_+\|DUF2330-domain-containing-protein	unknown	unknown	gnl\|CDD\|370813
NZ_CP029196.1\|WP_015033244.1\|2191154_2192216_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293811
NZ_CP029196.1\|WP_150160269.1\|2210128_2210779_+\|DUF1524-domain-containing-protein	unknown	unknown	gnl\|CDD\|377857
NZ_CP029196.1\|WP_150160261.1\|2200332_2201598_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP029196.1\|WP_015033245.1\|2192499_2193747_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239222
NZ_CP029196.1\|WP_150160260.1\|2197226_2198108_+\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|378961
NZ_CP029196.1\|WP_150160266.1\|2204580_2205375_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029196.1\|WP_150160265.1\|2204082_2204568_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP029196.1\|WP_015033251.1\|2198934_2200104_-\|steroid-3-ketoacyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181145
NZ_CP029196.1\|WP_150160267.1\|2205485_2207558_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|341045
NZ_CP029196.1\|WP_150160263.1\|2202872_2203541_+\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP029196.1\|WP_150160270.1\|2210965_2211529_+\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP029196.1\|WP_015033243.1\|2189568_2191032_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143457
NZ_CP029196.1\|WP_150160268.1\|2207705_2208845_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150160259.1\|2195529_2197230_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	2.3274e-80
NZ_CP029196.1\|WP_150160264.1\|2203701_2204031_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	1.2129e-23
NZ_CP029196.1\|WP_150160258.1\|2194420_2195533_+\|energy-coupling-factor-transporter-transmembrane-protein-EcfT	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	3.67149e-10
NZ_CP029196.1\|WP_015033250.1\|2198393_2198795_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|366654	pfam01464, SLT, Transglycosylase SLT domain. This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.	5.85051e-06
NZ_CP029196.1\|WP_015033260.1\|2209055_2209724_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.4503e-64
NZ_CP029196.1\|WP_150160262.1\|2201778_2202876_+\|DUF2330-domain-containing-protein	gnl\|CDD\|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	1.32812e-77
NZ_CP029196.1\|WP_015033244.1\|2191154_2192216_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293811	cd07725, TTHA1429-like_MBL-fold, uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain. Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	7.5144e-46
NZ_CP029196.1\|WP_150160269.1\|2210128_2210779_+\|DUF1524-domain-containing-protein	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	8.09208e-13
NZ_CP029196.1\|WP_150160261.1\|2200332_2201598_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.64921e-90
NZ_CP029196.1\|WP_015033245.1\|2192499_2193747_+\|hypothetical-protein	gnl\|CDD\|239222	cd02892, SQCY_1, Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.	1.99216e-07
NZ_CP029196.1\|WP_150160260.1\|2197226_2198108_+\|ECF-transporter-S-component	gnl\|CDD\|378961	pfam12822, ECF_trnsprt, ECF transporter, substrate-specific component. Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.	8.16287e-15
NZ_CP029196.1\|WP_150160266.1\|2204580_2205375_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.52931e-06
NZ_CP029196.1\|WP_150160265.1\|2204082_2204568_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.53385e-13
NZ_CP029196.1\|WP_015033251.1\|2198934_2200104_-\|steroid-3-ketoacyl-CoA-thiolase	gnl\|CDD\|181145	PRK07850, PRK07850, steroid 3-ketoacyl-CoA thiolase.	0
NZ_CP029196.1\|WP_150160267.1\|2205485_2207558_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.59587e-96
NZ_CP029196.1\|WP_150160263.1\|2202872_2203541_+\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	4.69253e-57
NZ_CP029196.1\|WP_150160270.1\|2210965_2211529_+\|DoxX-family-membrane-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.86206e-16
NZ_CP029196.1\|WP_015033243.1\|2189568_2191032_-\|aldehyde-dehydrogenase	gnl\|CDD\|143457	cd07139, ALDH_AldA-Rv0768, Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like. The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.	0
NZ_CP029196.1\|WP_150160268.1\|2207705_2208845_+\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	1.32154e-10

>NZ_CP029196.1|WP_150160261.1|2200332_2201598_+|cytochrome-P450
MAACPHLPEGHLPEGFDATDPDLLRERVPFPEFTRLRQTAPVWWCPQPPGVTGFADGGYWAVTRHADVKYVSTHPELFSSNENTAVIRFNEHITRDQIEVQKLIMLNMDPPEHTRVRQIVQRGFTPRAIRSLETALRDRARAIVDEAGRGADADGTFDFVTRVAVELPLQAIAELIGVPQEDRSRIFDWSNKMVAYDDPEYAITEEIGAEAAMELIGYSMNMAAARKECPAADIVSQLVAAEGQGNLSSDEFGFFVLLLAVAGNETTRNAISHGMHAFLTHPDEWELFKRERPATAAEEIVRWATPVVSFQRTATQDTELGGQKITKGDRIGLFYSSANNDPEVFTDPERFDITRDPNPHLGFGGGGPHFCLGKSLAIKEIELIFNAIADALPDLTLAGEPRRLRAAWLNGVKELRVRASA
>NZ_CP029196.1|WP_015033251.1|2198934_2200104_-|steroid-3-ketoacyl-CoA-thiolase
MAAEPVIVEAVRTPIGKRGGALANLHPAYLLGETYRELLGRTGIHADCVEQIVGGTVTHAGEQSMNPARTAWLTMGLPYETAATTVDCQCGSSQQASHMVANMVAAGVIDIGISCGVESMTRVPLGSGSKHGPGKPFPDEWNVDLPNQFEAAERIARHRGLTRERVDSLGLLSQERAANAWSEERFKRETFAVQVPTTEEEQAAGQGMWRLVDRDEGLRDTTMEGLARLKPVMPTAVHTAGNSSQISDGAAAIMWASKRMARALKLKPRARIVAQALVGADPHFHLDGPVDATRAVLGKAGMSLRDIDLVEINEAFASVVLSWAQVFDQDLEKVNVNGGAIALGHPVGATGARLITTALHELERTDKEFALVTMCAGGAVATGTIIQRL
>NZ_CP029196.1|WP_015033250.1|2198393_2198795_+|transglycosylase-SLT-domain-containing-protein
MIRSLATRVSARKKTFAASAAVLLGASGAVLGTTGSASAASPQELAREIVPASQYASFSKIVEHESHWNHTATNSSSGAYGLVQALPASKMSSAGSDWKTNPATQIKWGLNYMNERYGSPNAAWAFWQANGWY
>NZ_CP029196.1|WP_150160260.1|2197226_2198108_+|ECF-transporter-S-component
MSETTKAGARPVRLGPRSVTALVLVSLVGLAAFCWPLFADAGSAVTSHAGDAPWLFAALLPLLVAVVVATIADCGMDAKAVAMLGVLAAVGAALRPLGAGTAGLEPMFFLMVLSGRVLGPGFGFVLGAVTMFASALLTGGVGPWMPFQMLSMGWFTMGAGLLPGPGRLRGRGELLMLSAYGFAAAFAYGTIMNLQGWVLLQGLSSGISFQPGAPPYENLVRFLAYVTATSLGWDLGRAVLTVVLTLTIGGTLLRALRRATRRANFEAQVTFGGLEKPSAGEAPHRTYVTYEPE
>NZ_CP029196.1|WP_150160259.1|2195529_2197230_+|ATP-binding-cassette-domain-containing-protein
MIRFENVSVTYEGADERHEPTLRDVNLTVPEGELVLLVGPSGVGKSTLLGAVSGLVPHFTGGTLTGRVTVDGRDTRTHPPRELADLVGTVGQDPSAHFVTDTVEDELAYGMESLGLAPGVMRRRVEETLDLLGLAELRDRPIATLSGGQRQRVAIGSVLTPHPKVLVLDEPTSALDPSAAEDVLAVLQRLVHDLGTTVLLAEHRLERVVQYADQVLTLPEGVMGAPAEIMAVSPVHPPVVGLGRLAGWDPLPLTVRDARRRAGGLKAELEGRTWNPAPPAFEARGSGGGASGSRKGRGGGINLFKRRRTPAPAPATTPLVLTDALAVRRGRVEALRRVDLQVQAGETIALMGRNGAGKSTLLSALVGMIAPTSGTVRVAGRAPHATSPRELIRQVGLVPQEPRDLLYADTVAAECVAADADAGAEPGTCRALVSELLPMVSDATHPRDLSEGQRLALALAVVLTGRPPLLLLDEPTRGLDYAAKARLVARLRTLAAEGHAIVLATHDVELAAELAHRVVIIADGEVVADGPTAEVVVSSPAFSPQVAKILAPQPWLTVEQVAEALR
>NZ_CP029196.1|WP_150160258.1|2194420_2195533_+|energy-coupling-factor-transporter-transmembrane-protein-EcfT
MSVRVALRAPEADRANALHAGAWWLWALGLAVAASRTTNPLLLGLLVGVAGYVVAARRTDAPWARSYGAFVKLGLFVVALRVVFSLLLGSPIPGTHQLFTLPEVPLPDWAQGVRIGGRVTAEQLVFAVYDGAKLATLLICVGAANALANPARLLKSLPGALYEAGVAVVVAMTFAPNMVADVARLRTARRLRGRPTGGVRAVLQIGLPVLEGALERSIAVAASMDARGYGRTARVPASVRRTTNVLTLGGLLGVCAGSYGLLAAEGAGYGLPLLGAGLLAAMAGLRLGGRRTVRTRYRPDRWGARAWLVAGSGVAVAVLMIWANAYAPEELHPGVVPLEAPELPLWPAVSVLVGLVPAFVAPVPPAKEKT
>NZ_CP029196.1|WP_150160257.1|2193743_2194424_+|hypothetical-protein
MTLARRNGARVAGAAAGALLTLTGVVAAAAPAQAAGYRYWSFWESAGGKPWAYATQGPATARPADGDAIGFRFAISNGTNDTSQPTVTPDFPGICGGVAEKDGTKRVAVVVDFGGPADAPPGETPPEKLIKVGCAQVREDATGAEALAAVAKPLRYDSAAMLCGIAGYPARGCGEPVGDQAAASAAPSASASAGEGGGGPSLGVLVGGAAVLALGGAAVWKARRRG
>NZ_CP029196.1|WP_015033245.1|2192499_2193747_+|hypothetical-protein
MNTVRRGAAALAAATALLGTGAAGAATAAPSPSPSPVTIPDGLYGTKDPTYDGVWRQSLAFLAQRAAGFQPSDKAVGWLFDQQCEDGSFSSFRADDKAPCDAKTMRDTNATALAVQALQAVRNQSTFPEKADKAVKAGSDWLRSVQNKDGGWGYNPGGASDANSTSVVIGALAATGARPASFTSAEGRTPYDALLTFALPCSDKAGPGAFAYQPDKAGKLLANADATAAATLAGLGKGVVATKASPEQPPVCNDLSKPTIERASLNGASYLAKALAKTGHLNLPPMPGATDTSEQPDVGNTADAVVALAASGAAKEAKPALEWLEKNSAAWAKEGGPAAYAQLILAARATDTDPREFGTADLVEQLNATGPAPKTPDTSASSTSDDEGGFDVWWIIGIGMVVGVGIGFLVSGRKK
>NZ_CP029196.1|WP_015033244.1|2191154_2192216_+|MBL-fold-metallo-hydrolase
MQGSTQGPAPRVTEHGGGVWALRVPIPDNPLGHTLVHVLDTDRGPVLVDTGWDDPDSWTELTAGLDALGLSVRDVHGVVITHHHPDHHGLSGRVREESGAWIAMHAADTAVVRRTREAEPGTWLDYLARKLAAVGAPEDHLAPLRAARAPGRTRTLPGLRAALPDREIVPGELLDLAGRRLRAIWTPGHTPGHVCLHLEEEHPARRPGHGRLFSGDHLLPGITPHIGLYEDPDDATETDPLGDYLDSLERIGRLGVAEVLPAHQHSFTDAAGRVRELLDHHEERLTGLLGLLATPLTPWQLAVRMEWNRPWDQIPYGSRNIAVSEAEAHVRRLVKLGRAEAVPGTEPVAYVAV
>NZ_CP029196.1|WP_015033243.1|2189568_2191032_-|aldehyde-dehydrogenase
MTELVEHGKLFIGGELTDPLGADVIEVVSPHTEEVIGRVPHASTADVDAAVAAARRAFDEGPWPRMTLEERIAVVGRIKDAIAVRHEEIARSISAQNGSPYSWSVLAQALGAMMVWDAAITVARDFTYEERRGGVLGPLLVRREPVGVVAAVVPWNVPQFTAAAKLGPALLAGCTVVLKPSPESPLDSYILADIATEAGLPEGVLSIVPADREVSEYLVGHPGIDKVSFTGSVAAGKRVMEVASRNLTRVTLELGGKSAAVILPDADLATAVAGIVPAAWMNNGQACVAQTRILAPRSRYEEIAEAFAAAAGALVVGDPLDPATQVGPLVAQRQQRRSLDYIRIGQDEGAKVLAGGGRPAGLDRGWYVEPTLFGGVDNSMRIAREEIFGPVICLLPYGDEAEALRIANDSDFGLSGSVWTGDVEHGVDFARGVRTGTFNVNTFSLDMLGPFGGYKNSGLGREFGPEGLGEYLEHKMIHLPAGYEGGA
>NZ_CP029196.1|WP_150160262.1|2201778_2202876_+|DUF2330-domain-containing-protein
MRGTHRILATIVALLALQLGSLVAPAYACGCGAMIPTKEQRIGVDREESAVRWDGRTETVVMRFNVHGNARHAAWIMPVPHRADVSLGDPELFDEIDRLTEPEQRDRFHFWPRADDWPFDTDYGDGAGAPAPGAGTVGVVGRERLGPFDVARLTATDPEALGGWLRTHGYELPERLTGALQPYVDRRWEYVAVRLAPDEEDATLQGELTPLRITFASTELVYPMRLSRLATTSQSLGLSILSEHRMEPRSPIGGDAPEVTFAGRIERPSGALAALAGDRPVHLTVLEQEFPHPERIDDDHHLRAVADTPYRQVEYTDRLLTVGDGIPVWLLTVGGAMILAAVAALLAVRAARRRPTADTGVRSAP
>NZ_CP029196.1|WP_150160263.1|2202872_2203541_+|O-methyltransferase
MTNPQWNAVDAYFTETIAPADEVLTAALADSAAAGLPEIAVAPNQGKLLHLLALTQGARTVLEIGTLGGYSTIWLARALPADGRLITLEYDPAHADVARANIARAGLEKIVEVRTGAALDSLPLLEAEDAGPFDLVFIDADKVNNPRYVEWALELSRPGTLIIVDNVVRGGKITTPHPEDPAITGTRELFDLVAAEPRLDATALQTVGAKGYDGLLLARVVD
>NZ_CP029196.1|WP_150160264.1|2203701_2204031_+|antibiotic-biosynthesis-monooxygenase
MPSVVKINVLTVPAEQRAVLEQRFASRAGAVEGSDGFEWFELLRPVEGTDQYLVYTRWRSEEDFQNWMNGSMKAAHGGGGEGGGERPKPAASGSTLWSFEVVQQASPKG
>NZ_CP029196.1|WP_150160265.1|2204082_2204568_+|GNAT-family-N-acetyltransferase
MARMTWTFTPEHVHTPDAVALRRDFYDDVASRYWKRPATEAEIDQGLAGDGVERLTPPTGQFLVARHEGEPAGCGGVLLLDAERAELTRVFLRHAFRGLGGAAGLMRYLEDAARALGARRMVLNTRLDLVEARAVYTRHGYAEIPAYCTGPYMDIWYGKEL
>NZ_CP029196.1|WP_150160266.1|2204580_2205375_-|hypothetical-protein
MNSEEPRQGWPAPPGQPPTGPAGFGGPQGYGGYAAPAAPPTPPRTTSHRGAWIGAAATLVAAVIGVVGTYLVSSNNSSNSNNSAKPTPPQAQGPATSAGSPQTPESAATAGSTPGAESSATPSTEPPATPTGKPSGKPAGTVEWQGPLAIEYAEPKDLDSAPPTESEIREENDLSVYPLGDHMLRPEDGTKVLVWKDATNKTPSYEECARDIETLGTTTDLKLKTGLVVCATTNDGRLARLTVKELSGLASDTRGVFDVVVWSR
>NZ_CP029196.1|WP_150160267.1|2205485_2207558_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MAQEVRPAPPGGGAPAPGEAQSHRTVLVAIGALLLGMLLAALDQTIVSTALPTIVSDLGGLEHLSWVVTAYLLASTAATPLWGKLGDQYGRKKLFQAAIVLFLIGSALCGMAQNMPQLIAFRALQGLGGGGLMVLSMAIVGDLVSPRERGKYQGLFGAVFGATSVLGPLLGGLFTEHLSWRWVFYINLPIGIVALFVIAAVLHIPVRSTRHTIDYLGTFLIASVATCLVLVASLGGTTWAWGSAQIIGLAVLGAVLLVWFVYVERRAAEPVLPLKLFRIRTFSLVAVISFVVGFAMFGAMTYLPTFLQVVQGVTPTMSGVHMLPMVAGMLITSTASGQIVSRTGRWKVFPIAGTALTALGLLLLNELTETTSTWVMSVYFFVFGAGLGLVMQVLVLVVQNAVAYQDLGVATSGATFFRSIGASFGVAVFGTIFTNRLTHKLDDVFAGAAASGQELPPGVGADQVAADPRAIEQLPAALRPSVLHAYATSITDVFLYAAPVVLVAFVVAWFLKEDKLRASVTAPDTSQTLASNPVERSSYDECARALSVLGSREGRKAIYEKITARAGLDLLPAASWLLLRIRRHGTVEPARLAEHVPVPLRVITEASRQVEERQLATREGLQLVLTEEGVAVATRLAAAREESLAELLGDWWGPDRPTDLVKLVEELTAELSGSDGERPHDPEPPRDHHA
>NZ_CP029196.1|WP_150160268.1|2207705_2208845_+|peptidoglycan-binding-protein
MTGHACPECGAQRPGCACAQAELAAAEDFDPLRIRPYVTLDAPEDPPGGGPGGGAQDAPGGGVGGPGSYGADGPPTAQLTAIRPEGVGGGPEAYPTASTASHSTDTYLTGAYPTAPHPADAYPAGPAGDPYPAGPAGDPSETMPLLLRGVGDVPPPPGHERGEGRGRGRRRGVLVAAVAAVAVAGTAALAATVLGGGEGTDDRAAVPDVTTSASLNLAVSEAPSASSGSPEPRTSSPTPSRTPTPTSSSPSPSASRTTSTPSAPARTTGAAAPPASSSAPVTAPTTTRPATTTPPAEVPGEGEEDVVTLSLGSSGPEVRELQRRLEAVWAYHGRINGRFDEEVQEAVARYQSWRYVQDDPEGVYGPTTRRLLEENTPEV
>NZ_CP029196.1|WP_015033260.1|2209055_2209724_+|HAD-IA-family-hydrolase
MPATTPATLTARALLLDMDGTLVNSDAVVERCWRRWAERHGLDADAALKVVHGRQGYATMAVLLPDRPMEENYADNRVMLAEETADLDGVVPVPGAPAFMAALAELPHALVTSADEALAQARMGAAALPMPETRVTAECVGASKPDPEGFLKGAAELGFAPADCVVFEDSEAGIQAGRAAGMRVVGVGPRAAAFAPDVHVADLTHLRVEPAADGGIALTVLP
>NZ_CP029196.1|WP_150160269.1|2210128_2210779_+|DUF1524-domain-containing-protein
MPIGMIYARRLAVLATSAALAGTGFLATAPAAQAAMPTPVSAATARTYLAALTVKAEGSSSGYSRDLFPHWITQSGACNTRETVLKRDGVNVVTDSSCAATSGSWYSQYDGATWTVASDLDIDHMVPLAEAWRSGANSWTTSQRQSFANDLTRPQLIAVTDNVNQSKGDQDPAEWLPSRTAYRCTYARAWVHVKYYWNLSVDSAEKSALQSVLNGC
>NZ_CP029196.1|WP_150160270.1|2210965_2211529_+|DoxX-family-membrane-protein
MNNPNTTNTTSTTGSPTGPTGPTGSGASSPGASTLTGRLDRAQPYALGLFRIVVGLLFACHGAASLFGVLGGAMGGGTVPAGTWPSWYAAVIQLGAGGLVLLGLGTRTAAFLASGSMAYAYFKVHQPESLFPLQNGGETAALFCWAFVLLVFTGPGALALDRLFGGRVGAGSAPRAEREEKATPVTA

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Crispr_ID: NZ_CP029196_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_5

2301014-2301118

Orphan

Consensus_repeat	Method
TGCTCTGCCAATTGAGCTACAGGGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_5

>merge|NZ_CP029196|5|2301014-2301118|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGATCGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGCTGCTCTGCCAATTGAGCTACAGGGGAT

>NZ_CP029196|5|3|2301014-2301118|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGAT	CGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGC
TGCTCTGCCAATTGAGCTACAGGGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150160318.1\|2292844_2294443_+\|terpene-cyclase/mutase-family-protein	unknown	unknown	gnl\|CDD\|238362
NZ_CP029196.1\|WP_150160328.1\|2311164_2312427_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP029196.1\|WP_150160322.1\|2299206_2300544_+\|chloride-channel-protein	unknown	unknown	gnl\|CDD\|238233
NZ_CP029196.1\|WP_150160324.1\|2303142_2304876_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP029196.1\|WP_015033462.1\|2312568_2313888_-\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|235098
NZ_CP029196.1\|WP_150160329.1\|2313923_2314688_-\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_CP029196.1\|WP_150160327.1\|2309249_2311142_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP029196.1\|WP_150160315.1\|2289991_2290681_+\|NAD(P)H-oxidoreductase	unknown	unknown	gnl\|CDD\|236620
NZ_CP029196.1\|WP_150160320.1\|2297986_2298670_+\|GAP-family-protein	unknown	unknown	gnl\|CDD\|378566
NZ_CP029196.1\|WP_015033454.1\|2301287_2301599_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160319.1\|2295683_2297738_+\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NZ_CP029196.1\|WP_150160316.1\|2290677_2292159_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP029196.1\|WP_150160321.1\|2298773_2299184_+\|amphi-Trp-domain-containing-protein	unknown	unknown	gnl\|CDD\|275149
NZ_CP029196.1\|WP_015033446.1\|2295030_2295447_+\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NZ_CP029196.1\|WP_150160325.1\|2304875_2306801_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP029196.1\|WP_150160326.1\|2306822_2308073_+\|TerD-family-protein	unknown	unknown	gnl\|CDD\|132992
NZ_CP029196.1\|WP_150160323.1\|2301628_2303068_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP029196.1\|WP_150160317.1\|2292271_2292799_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|185291
NZ_CP029196.1\|WP_150163557.1\|2308091_2309042_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NZ_CP029196.1\|WP_015033445.1\|2294439_2294922_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150160318.1\|2292844_2294443_+\|terpene-cyclase/mutase-family-protein	gnl\|CDD\|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	3.88704e-19
NZ_CP029196.1\|WP_150160328.1\|2311164_2312427_-\|oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	4.9254e-72
NZ_CP029196.1\|WP_150160322.1\|2299206_2300544_+\|chloride-channel-protein	gnl\|CDD\|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	1.87084e-30
NZ_CP029196.1\|WP_150160324.1\|2303142_2304876_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.61983e-164
NZ_CP029196.1\|WP_015033462.1\|2312568_2313888_-\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP029196.1\|WP_150160329.1\|2313923_2314688_-\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	6.16309e-29
NZ_CP029196.1\|WP_150160327.1\|2309249_2311142_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP029196.1\|WP_150160315.1\|2289991_2290681_+\|NAD(P)H-oxidoreductase	gnl\|CDD\|236620	PRK09739, PRK09739, NAD(P)H oxidoreductase.	1.86069e-65
NZ_CP029196.1\|WP_150160320.1\|2297986_2298670_+\|GAP-family-protein	gnl\|CDD\|378566	pfam11139, SfLAP, Sap, sulfolipid-1-addressing protein. SAP is a transmembrane transport protein with six predicted transmembrane helices, with a hydrophilic domain between helices 3 and 4. This hyrodphobic region is highly variable among identified Gap-like (GPL, peptidoglycolipid, addressing protein) proteins and may be involved in substrate recognition. SAP also belongs to the LysE protein superfamily (pfam01810), whose members have been implicated in small molecule transport in bacteria. Other Gap proteins export metabolites across the cell membrane so it is possible that Sap specifically may be involved in transport of sulfolipid-1 across the membrane.	6.96445e-23
NZ_CP029196.1\|WP_150160319.1\|2295683_2297738_+\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NZ_CP029196.1\|WP_150160316.1\|2290677_2292159_+\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	1.50696e-74
NZ_CP029196.1\|WP_150160321.1\|2298773_2299184_+\|amphi-Trp-domain-containing-protein	gnl\|CDD\|275149	TIGR04354, conserved_hypothetical_protein, amphi-Trp domain. This domain usually comprises most of the span of bacterial or archaeal proteins with a length of about 90 amino acids. Some members, however, are extended by one or two copies of domain pfam07411 in the C-terminal region. No residue in this domain is invariant. A striking feature of this domain is a C-terminal region that alternates strongly charged with strongly hydrophobic residues and usually ends with a Trp residue, e.g. LEIEIEW or FEIKVRW, suggesting an amphipathic beta strand structure. We suggest the name amphi-Trp for this domain. Some members of this function occur regularly in genomic contexts that include putative kinases of unknown specificity related to (but distinct from) HPr kinase, a Ser-specific protein kinase. The function is unknown.	1.63592e-13
NZ_CP029196.1\|WP_015033446.1\|2295030_2295447_+\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	4.37991e-60
NZ_CP029196.1\|WP_150160325.1\|2304875_2306801_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP029196.1\|WP_150160326.1\|2306822_2308073_+\|TerD-family-protein	gnl\|CDD\|132992	cd06974, TerD_like, Uncharacterized proteins involved in stress response, similar to tellurium resistance terD. Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.	1.53804e-23
NZ_CP029196.1\|WP_150160323.1\|2301628_2303068_+\|sugar-kinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	9.03446e-120
NZ_CP029196.1\|WP_150160317.1\|2292271_2292799_+\|NUDIX-domain-containing-protein	gnl\|CDD\|185291	PRK15393, PRK15393, NUDIX hydrolase YfcD; Provisional.	4.2411e-14
NZ_CP029196.1\|WP_150163557.1\|2308091_2309042_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	5.02713e-162
NZ_CP029196.1\|WP_015033445.1\|2294439_2294922_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.04064e-23

>NZ_CP029196.1|WP_150160322.1|2299206_2300544_+|chloride-channel-protein
MTEADARPEEPGSGEQPLEADRLRDLLLTPGYFKTLTVSALIGVPVSLVAFWFLVGLHQLEHLLWADLPHDLGWDTPPWWWPLPLLLVAGAVVGLVAARLPGGGGQVPASGLHAGGASTATLPGVVIAATASLPLGAVLGPEAPLIALGGGLALLVRDLTRGPATPATTVLLGAAGAAAAIAAIFGNPLVAAVLLMEVAGAGGPRLFAVMLPALLSSGVGALVFTGFGRWTGLETGSLALRLPTPFPALDIGDVLWTVPLALAVAVLLHPLLRAARRVAAFVAAGPVARTALCALAAAACAALYALLTDRSPADVALSGQATLGQLAADPHAWGAGALVAVLLLKGTAYALCLGSLRGGLVFPALFLGAAAGVLLAPLPGLGLVPALAAGMAAATAAALRLPVSSVVLVVLLLGGTAMIPVVILAAVISLVTTEVLPEARAAPPA
>NZ_CP029196.1|WP_150160321.1|2298773_2299184_+|amphi-Trp-domain-containing-protein
MKDLKFEQKRSMTRLEAADQLAALAAALREGGDVELEYGQGTLSLYIPEELRTEVEVEVGNGEIELEIEFKWPTARVRKARESGREQPAPEAEPAKAPARRKSASARPPRTATGTKRSASGTKKTAGSRPPAAKKS
>NZ_CP029196.1|WP_150160320.1|2297986_2298670_+|GAP-family-protein
MVLDLFLIGLAVALYPLPGMALVLVLASPRGVYKGLAFITAWLACLVAVIALVLLCTGGEPPSPRSPPSLAALAATLVIGLGLIVYSEHRRRRSRRVNASAPSDGGSRTAGSGHSLTSRMDQATGWSAAGLAVLLQPWGMVSAAAATVVKADASHAQSFLALLGFCVLATSTLLAMELYTVFAPEDAQRDLTRLRAWLSRHKDQAIVLLCLLLGLWLVGRSLYQLTG
>NZ_CP029196.1|WP_150160319.1|2295683_2297738_+|phospholipase-C,-phosphocholine-specific
MADLDRRRFLQLAGGAAAFTMLSESVARAAAIPAQGSTGTIQDIEHIVVLMQENRSFDHYFGAMKGVRGFGDPRPVTLPSGKSVWNQSDGSKVTLPFRPTSDKLGMEYLQGLNHDWAGGQSAFNKGKYDNWVPAKTKATMAHLTREDIPFHYALADAFTICDAYHCSFIGATDPNRYYMWTGYVGNDGKGGGPVLNNAEAGYGWTTYPERLEAAGVSWKIYQDIGDGLNAAGSWGWINDAFRGNYGDNSLLYFNNYRNAQPGNPLYDKARTGTNAKAGEGFFDILRADVQGGRLPKVSWIAAPEAFSEHANWPSNYGAWYIAQVLDALTSNPDVWARTALFITYDENDGFFDHVVPPYAPGSAAQGLSTAPTALDYFGGKTGYVAGPYGLGPRVPMIVVSPWSTGGYTCSETFDHTSVIRFMEQRFGVTEPQISPWRRAVCGDLTSAFDFSRTDTSAAPLPPVAGYYPPDKNRHPDFLATAPASGTMPRQERGAKPTRPLKYAPYVDGAADIAAGKFRLTFSGGPAAGAQFYVTSANRTDAPWTYTAEAAKSISDTWNTTYSKGVTDLTVHGPNGFVRRFRSPGKTAVPEVTARHNATTGQLDLTFTNAGTTATVTLTNAYGGTPATLTVAKGATVTRTVDVSAAHRWYDITVTSSASTDYVRRLAGHVETGAPSQSDPAILTY
>NZ_CP029196.1|WP_015033446.1|2295030_2295447_+|organic-hydroperoxide-resistance-protein
MDAIYTAVATANGREGRAVSSDGHIDLPLAHPQALGGNGQGTNPEQLFAAGYAACFASAMNLVARQEKIDITDASITAEVSIGKDPADGGFGLSVVMRAEFPDHLQGAAGAALLEKTHAFCPYSKATRGNIKVDLVVE
>NZ_CP029196.1|WP_015033445.1|2294439_2294922_-|MarR-family-transcriptional-regulator
METLDTAPDEDFLRLDDQICFSLHAATRAFNGVYREALKDLGITYPQYLVMLVLWEHGELPVKGIGERVRLDSGTLSPLLKRLEAAGYVERRRSPEDERSVTVRPTAEGTALREKARGVPRRIAAATGLELGELRDLRERLDALAVRLGGVDPDDLNTCR
>NZ_CP029196.1|WP_150160318.1|2292844_2294443_+|terpene-cyclase/mutase-family-protein
MTYCAPPLPGASLAVPGAGRPSADGLDHARARLATRLVAAAAPDGLLRAPCESRVLESALALRLLTVTGVDPDAQERLTRRLKTALDEGGTDPVQEAAARAALGEYVDGPAALARLLDGFDHFTAGRKRLMFQTVLAELGAHPYPELRSPGDVFEARGQQRWLVTEMAALKVLHAFGTGSPRLVAEADWRALAPCARPGPPPYGNHLVRTLGLLALRHSTRHAAAVAARARELRAGLREDGGLPYITGLDVFATALGGLALAGAGAPALTLRALATALTERQNADGGWGFDRGVAQSDVDDTSYCVEFLRAAAPERYGAEVAAGERYLLSRAGADGGFPTFEPGTASEVAITAAAVNALAPVPAHRSVVEAGVRFLVDRQGAAGPVERSWSLNESNALFRTVLAYDSCRAAVPGGPAAAGAGRARARAVARLLATRNEDGGWGHVPSDPSDPISTAYALIAVARTPAEPAAVAATERAVRYLLDRQRPDGGFVSRPDQAGPRPFAYHVPLLTDVCVLLGLNHAAAARGRAGA
>NZ_CP029196.1|WP_150160317.1|2292271_2292799_+|NUDIX-domain-containing-protein
MRLRWVVMRTRRVTHEQVDHVDPGDRVVAQGRRTDAPPAGLLRRYAATVCSDHAGRVLLYRRTPTVRAYPDHYDVLVGGAVRTGEEYLAAALRELREELGWTAAPGIAEAYRVRVDDPHGACFLTVHRWVADRPPRPDPREIAWCGFVAPLTVMTGGYTPMVPAGAEAVRCLFPL
>NZ_CP029196.1|WP_150160316.1|2290677_2292159_+|MFS-transporter
MTTTLAENTATPPRAGARQWLGLAVLLLPVTLMTADLGVLWLATPYLSADLRPSGAQLLWITDIYGFLTAATLVIMGTLGDRLGRRKLLMAGSAGFLLASVLAAYAPNAGTLIAARALLGVAGAAVLPSTLALISHMFTDARQRATAIAMWVTALSVGLAIGPVIGGVLLASWWWGSVFLMGLPVMVIALVTAPLLLPEYRDPNPGRLDPASVLLFLLAVLPLVYGVKSLAAHGPTAEAAVAFALGLAFTVLFVRRQNRLVSPLLDLRLFGNRAFTGALLTLLLGMTALNGVEYLVPQYLQAVAGLPPLEAGLWLLPGAAGLIAGSQLTPFAARRVRPAYVLAGGLLISLAGYAVIALAEGVTAAALGLAVIMFGAAPISVLGTALAVGSAPAEKAGAAAATGQTAYDLGLALGIAVTGSVAVAVYRGGIPADAPAAAHESVGAALALPDEGLREQAREAFTTALHWASTLSAVFALVTAVVVLTLLRKVPRT
>NZ_CP029196.1|WP_150160315.1|2289991_2290681_+|NAD(P)H-oxidoreductase
MARHTLLVLAHPRSDSLTAQVAARLHARLKVEGGTVDVLDLYAEGFDPVLRPEDEPDWENREKVYSPVVHAHMDRVLAADDVLVVFPVWWFTPPAILKGWIDRVWNYGFAYGRSRPRLAGKRLLWLALMGGTPEEIERLGMTEALGLMLVTGISAFCGLPDASLRVLHGTELSGVPAELRADRVAELLDQAERTLTEELLTPGAPDAPETPGAPVINPAPKSVDEEPAR
>NZ_CP029196.1|WP_015033454.1|2301287_2301599_+|hypothetical-protein
MRYKLTFVVGLALGYVVGTRAGRERYEQMKKSAKDLARNPAVRNAAESAAQTGRQVAGKAAHVVGDKVGDRLPSSVTDRFHALSGRGGANGKVEEDDWGTSNT
>NZ_CP029196.1|WP_150160323.1|2301628_2303068_+|sugar-kinase
MGIVAGLDSSAEFTRIVVCDTDTGAVLRQGYAPHPGEPKAVDVDPQTWLLSLGEAATGGLLEGVQAIGVSAQQHGLVPLDAQGGLVRPALVRNDKRAQVAAADLVESLGGRQAWAEAVGSVPGAGQPVAKLRWLARTEPEHAARVAMILQPHDWLVWQLLGRPARRTTDRGAASGTGYWSARTGSYRPDLVELALGHQAVLPEVLGPAEAAGTTPEGLLISAGTGETMAAALGLGLGPGDAVVSLGASGSVMAVHHEALSDPRGMITSFADATGMHLPVVHTSNAVRTLRGTAEMLGVESLEELSALALKSTPGASGLVLLPYLEGERTPSLPHSAGTLSGLRRESMKPEHLARASFEGMLCGLTDAMDVLRGRGVEVRRVFLLGAAAALPAVQALAPALFGAQVVVPQPADYAALGAARQAAWALGVARGTLSPSAPPAWQGAAAQILEPGEDLAAGQAVRQQYVATRDQLHPGAFGS
>NZ_CP029196.1|WP_150160324.1|2303142_2304876_+|ATP-binding-cassette-domain-containing-protein
MLIRLLRTHLGPYRKPIALLVFLQFLQTCASLYLPTLNADIIDNGVVDGDTGYILRFGALMVGVSVVQVVCNVGAVFYGARTASALGRDVRAAVFDRVQSFSARELGHFGAPSLITRTTNDVQQIQMLVLMAFTLMVSAPIMCVGGIVMALGQDVPLSGVLLAVVPVLGVSVSLIVRRMRPLFRTMQERLDTVNRVLREQITGNRVIRAFVKDGYEEERFRGANAQLTDVSMATGRLMALMFPVVMTVVNISSVAVVWFGAHRIDSGGMQIGALTAFLAYLMQIVMAVMMATFMFMMVPRAEVCAERIEEVLATETSVVPPVKPVTKLDRRGHLEVRSADFRYPGAEESVLKDVGLVARPGETTAIIGSTGSGKSTLLGLVPRLFDATGGEVLVDGVDVRELDPRLMAKTVGLVPQKPYLFSGTVATNLRYGKPDATDEELWHALEVAQAADFVRKLEHGLNSPIAQGGTNVSGGQRQRLAIARTLVQRPEIYLFDDSFSALDYETDALLRAALAEETADSTVVIVAQRVSTIRDADRIVVLDEGRVVGTGRHQELMADNETYREIVLSQLTEAEAA
>NZ_CP029196.1|WP_150160325.1|2304875_2306801_+|ATP-binding-cassette-domain-containing-protein
MAGPGGRMMAGGGPDQRSMDFKGSGKRLLKQLAPERGALWVMLLAGVLSVAASVIGPKILGRATDLVFAGVIGRQIEGGTKPEAIERLRAAGDSGMADMLSGVDFTPGQGIDFSAVGGVLLLVLGVYVAAGLLMLVSTRMSIKVINRTVYRMREDVQTKLARLPLSYFDKAKRGEVLSRATNDIDNISQTLQQSMGQLINSLLTIVGVLAMMFWISPLLALVALITVPVSVFVAAKIGKRSQPHFVQQWKSTGALNAHVEEMYSGHTLVKVFGRQEESARDFREQNEALYEAGFKAQFNSGVMQPVMFFISNINYVLVAVVGGLRVASGTLSIGDVQAFIQYSRQFSMPLTQVASMANLVQSGVASAERIFELLDAEEQEPDAPTGEKVADLKGKVALEGVSFRYEADKPLIEDLSLTVEPGQTVAIVGPTGAGKTTLVNLLMRFYEVTGGRITLDGVDIAGMSREQLRAGIGMVLQDTWLFGGTIADNIAYGATREVTRAEIEEAARAAHADRFVRTLPEGYDTVIDDEGAGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKAMARLAHGRTSFVIAHRLSTIRDADVILVMENGSIVEQGTHEELLASGGAYSRLYAAQFAQAVAEVD
>NZ_CP029196.1|WP_150160326.1|2306822_2308073_+|TerD-family-protein
MMGGMGHMGHMAKSSWVPSVTLRVGAGGVDVAALLLAADGRVRGDADMVFDGQPAHPSGAVRHEQASLLLALHEVEADVERIVIAGSAAGGALTAVAPDGAAVAAHTVAAAPETTAVVLAEFFRESGGWKFTGGGKGYGSGLAALVTEFGVEVADETGAAQQQPEPVAAGPVPLTGVVKMPVRARQAGGSSAAGAAPGHGGPPVPGGPFPPADRPYELVGGWEFGPVFEPFTITGDGDQVVTVDDRVPPGPVLVETAHEGRDGYFAVFPLDQRNKDGQYLFSTALPDFRGSSVTPAPEGRALRLRVRAYHRWVMRVKPVAAARRIEGTLRGYGPEALLYTGGAADLQVHFEGDEDGGGYVGIRCHEVAGHTGLTERPTLLLNRTEPLLHTVPLPPGPLLLLHRADGPWTLTVKELD
>NZ_CP029196.1|WP_150163557.1|2308091_2309042_-|sigma-70-family-RNA-polymerase-sigma-factor
MPPQRRRPDLGGNGPSSDLFRQYLREIGRIPLLTAAEEVDLARRVEAGLFAEEKLANTPDLDSRLASDLDRLVVLGRIAKRKLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVIRVQRRMLQERGYEPTAEEVAAQLDLAPERVGEVLRLAQEPVSLHAPVGEEEDVALGDLIEDGDAASPVESAAFLLLRRHLEDVLSTLGERERKVVQLRYGLDDGRPRTLEEIGRIFGVTRERIRQIESKTLGKLRDHAYADQLRGYLD
>NZ_CP029196.1|WP_150160327.1|2309249_2311142_-|DNA-primase
MAGRINDDDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPSKGLFHCFGCQEGGDTIAFVMKIDHLSFSETVERLAAKAGITLRYEEGGYNPGHQRGERIRLIEAHKVAAQFYADQLGSPEAEIGRAFLAERGFDQAAAAHFGVGYSPAGWDHLTRYLRGKGFSDKELILSGLSQDGRRGPIDRFRGRLMWPIKDVGGEIVGFGARKLRDDDNGPKYLNTPETPIYKKSQVLYGIDLAKKDIAKVSRAVVVEGYTDVMACHLAGVTTAIATCGTAFGGDHIKILRRLLMDNGSARVIFTFDGDSAGQKAALRAFEDDQKFAAETYIAIAPDGMDPCDLRLAKGDEAVVDLVQPRTPLFEFALRQIVKRYDLETPAGRAAALDEAAPVVARIKNIGAQHEVAVQLAGMLGILDTQFVVKRVAQLARWARDRGGKGPERQQGPQRGYDTAAPAPAPSGPALNLRSPAHRTERELLKLALQRPELVSPAFDAYGVDEFTAPPYAAVRQCVQDAGGATGAPADYLDAVREAAPNDTVRALVTELAVETIFAKTVDEAYAGDQLVTVRLRAVDRRIRDVQGTLARLGAQGDPERLAAVQNELWVLTQYGQSLRNNGAAAL
>NZ_CP029196.1|WP_150160328.1|2311164_2312427_-|oxidoreductase
MVDADQTFVIVGGGLAGAKAAETLRAEGFNGRVILIGDERDHPYERPPLSKGYLTGAKERDSAFVHEAAWYARHDIELHLGQSVTAVDREAHTVRLGDGTVIRYDKLLLATGAEPRRLDIPGTELAGVHHLRRLAHADRLRQVLASLGRDNGHLVIAGAGWIGLEVAAAARGYGAEVTVVESDPTPLHRVLGPELGQLFADLHTDHGVRFHFGARFTEIVGQDGMVLAVRTDDGEEHPAHAVLAAIGAAPRTALAENSGLALVDRADGGGIAVDESLRTSDPDVFAAGDVAAAHHPLLHTRLRVEHWANALNGGPAAARAMLGQHVSYDRVPYFFSDQYDLGMEYSGWAPPGSYDQVVVRGDTGKREFIAFWLKEGRVLAGMNVNVWDVTDPVQQLIRARKPVDPDALADASVPLESLIA
>NZ_CP029196.1|WP_015033462.1|2312568_2313888_-|deoxyguanosinetriphosphate-triphosphohydrolase
MEGITDTSGQDTPADTPGYDSAATERWDTEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVTPGTRGHAWDASPRTRLTHSLECAQVGRELGAALGCDPDLVEAACLSHDMGHPPFGHNGEQALNDVAKDCGGFEGNAQSLRLLTRIEPKRFVKDADGELVSVGLNLTRAALDAATKYPWPRGAHPEDPGSPKFGVYEDDLPVFAWIREGAPAHRKCFEAQVMDWSDDVAYSVHDFEDGLHAGHIDPNLLLAEPERADIAAVAIGRYVPEDTDPQELAEALDRLVDQEWWPHGYDGSAVAQARLKDATSQLIGRFCLAAEGATRQAYGSGGLTRYGAELVVPREARNECAVLKAVADRYVMQRPQQEALRADQRIVVAELAEALVARAPDGLEPQFRSLFDAARDDRARKRVIVDQIASLTDASARALHAALRPHHS
>NZ_CP029196.1|WP_150160329.1|2313923_2314688_-|sirohydrochlorin-chelatase
MTEPHTPRRRPTLVAVGHGSRDPRARATLSRLLDRVRELRPGLDVRLAHIELNAPLLDATLAELAAEGRDAVLVPLLLAPGHHVTHDLPAALAAVPALRARLAAPLGAHPLLVEALADRLAQAGWTPGDGDSPATGIVLASAGSRDPRSGAETRRIAALLGERLGGVPVLPAYASAAAPTVPEAVRVLTARGRHRIAVASCFTAPGLFATRAAAHAPWIASDPLGAHPALARLVLHRYDTAPRPTTRGRELATV

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Crispr_ID: NZ_CP029196_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_6

2400635-2400695

Orphan

Consensus_repeat	Method
CGGGCGGGGCTCGTACGGCTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_6

>merge|NZ_CP029196|6|2400635-2400695|CRISPRCasFinder
CGGGCGGGGCTCGTACGGCTCCGACAGCTCCGTCGGCCTGGGCGAGGCTCGTACGGCTCCG

>NZ_CP029196|6|4|2400635-2400695|CRISPRCasFinder
CGGGCGGGGCTCGTACGGCTCCG	ACAGCTCCGTCGGCC
TGGGCGAGGCTCGTACGGCTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150160371.1\|2388741_2390088_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|223540
NZ_CP029196.1\|WP_150160378.1\|2410260_2411532_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP029196.1\|WP_150160376.1\|2408365_2409256_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377274
NZ_CP029196.1\|WP_150160370.1\|2387650_2388745_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274350
NZ_CP029196.1\|WP_150160379.1\|2411528_2412152_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378968
NZ_CP029196.1\|WP_150160373.1\|2396429_2400581_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|274008
NZ_CP029196.1\|WP_015033539.1\|2394614_2395343_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293840
NZ_CP029196.1\|WP_041662379.1\|2408068_2408311_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160377.1\|2409375_2410221_-\|arylamine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366312
NZ_CP029196.1\|WP_030317512.1\|2406168_2406435_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
NZ_CP029196.1\|WP_150160372.1\|2395353_2396154_+\|DUF3097-family-protein	unknown	unknown	gnl\|CDD\|378628
NZ_CP029196.1\|WP_041662374.1\|2387209_2387569_-\|histidine-triad-nucleotide-binding-protein	unknown	unknown	gnl\|CDD\|238607
NZ_CP029196.1\|WP_015033545.1\|2404119_2405985_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP029196.1\|WP_015033538.1\|2393444_2394464_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP029196.1\|WP_015033537.1\|2392307_2393444_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237654
NZ_CP029196.1\|WP_015033535.1\|2390206_2390950_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	unknown	unknown	gnl\|CDD\|367950
NZ_CP029196.1\|WP_015033544.1\|2402046_2403924_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP029196.1\|WP_150160374.1\|2400723_2401965_-\|coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180172
NZ_CP029196.1\|WP_150160375.1\|2407002_2407992_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
NZ_CP029196.1\|WP_015033536.1\|2390946_2392026_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|367316

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150160371.1\|2388741_2390088_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|223540	COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones].	6.26148e-84
NZ_CP029196.1\|WP_150160378.1\|2410260_2411532_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.24887e-57
NZ_CP029196.1\|WP_150160376.1\|2408365_2409256_-\|hypothetical-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	1.39979e-49
NZ_CP029196.1\|WP_150160370.1\|2387650_2388745_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	2.9332e-12
NZ_CP029196.1\|WP_150160379.1\|2411528_2412152_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	3.41813e-10
NZ_CP029196.1\|WP_150160373.1\|2396429_2400581_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.15597e-11
NZ_CP029196.1\|WP_015033539.1\|2394614_2395343_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.7774e-46
NZ_CP029196.1\|WP_150160377.1\|2409375_2410221_-\|arylamine-N-acetyltransferase	gnl\|CDD\|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	8.12156e-83
NZ_CP029196.1\|WP_030317512.1\|2406168_2406435_+\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	4.23035e-22
NZ_CP029196.1\|WP_150160372.1\|2395353_2396154_+\|DUF3097-family-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	9.30592e-163
NZ_CP029196.1\|WP_041662374.1\|2387209_2387569_-\|histidine-triad-nucleotide-binding-protein	gnl\|CDD\|238607	cd01276, PKCI_related, Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.	1.85827e-53
NZ_CP029196.1\|WP_015033545.1\|2404119_2405985_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP029196.1\|WP_015033538.1\|2393444_2394464_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	1.92599e-157
NZ_CP029196.1\|WP_015033537.1\|2392307_2393444_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237654	PRK14278, PRK14278, chaperone protein DnaJ; Provisional.	0
NZ_CP029196.1\|WP_015033535.1\|2390206_2390950_-\|16S-rRNA-(uracil(1498)-N(3))-methyltransferase	gnl\|CDD\|367950	pfam04452, Methyltrans_RNA, RNA methyltransferase. RNA methyltransferases modify nucleotides during ribosomal RNA maturation in a site-specific manner. The Escherichia coli member is specific for U1498 methylation.	3.60548e-76
NZ_CP029196.1\|WP_015033544.1\|2402046_2403924_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_CP029196.1\|WP_150160374.1\|2400723_2401965_-\|coproporphyrinogen-III-oxidase	gnl\|CDD\|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	0
NZ_CP029196.1\|WP_150160375.1\|2407002_2407992_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	3.10825e-89
NZ_CP029196.1\|WP_015033536.1\|2390946_2392026_-\|nitronate-monooxygenase	gnl\|CDD\|367316	pfam03060, NMO, Nitronate monooxygenase. Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.	3.81019e-111

>NZ_CP029196.1|WP_150160373.1|2396429_2400581_+|tetratricopeptide-repeat-protein
MDEVTAEHAGGDEPVARDRADGDEPVAADRADGDEPVAADRADGDEPVAAELVPLDDVAKARFMGLRPIPDHVEGERRELAVALRRCFFELECTLRRYAVQRSYSASSLSRYLSGETPAPDHFVNALMDDVGKKLGRPMSPQARQAVILMQRAALKSVNTRAWQIQRLEDQLAAALQEKALARTMADAVATALHEHQERVVTLEAERQALTEEVAAQRTAGIELALLRAEQHRVLTDHEALRRRVAELEAALEAAEQRVALAEQRCADLEHTLLAADAAAAAEEEADRRRTEERLARSQEELERLRREVASLRSRPAESTPPGRHDWMGDGPAPGPEPGSRRETDPEAQPQTATPSQPRPQTATPLLAHPETQTQPQPDAPPPPLPSPRTAPASHVTVVFAAPQRPWGTWIAHRLERHGHRATLQRWDPPREVPLEQVLRDLLLARGQILFVLDDWFFDRGARQAGEWNEVLRGFVAAHADRFAAVDLSSRTLPPSAAVLEPVSLWGVDEAEAGARLTHRLALAGNRDGARRHRGATPARFPADPPAVWGAVPRRNPWFSGRDDLLGALQQRLAEAGHGSAACALIGMSGIGKTQIATEYAYRFSPDYDVIWWVHSEDRNVLRDRLGDLAVELGLRVGSEPGERVRAVREALRRGDPHARWLVVFDGWDDTDGIDVMLPQGPGHVLITSRNRGWREHTDVLEIPGFDRRESTGYLMRRAPQINAAEADEVAAEFGDVPLPLAQAAAWLGESGTEAAEYLRMVRDGRLSTVDEPSPDNATPHVSLSSWQILIDRLRRSHPQALQVLSLCTAFAPGPVPLGLLRADPAARLPADLRWITTDPAAWTRALDTLVNYSVLVRTPSPSAGGKAAGPEEETVHMHRLVHDIVARLTDDEGRYARLKAVRDLLAEAEPGDPADSGHWPRYSVLLPHLEPSGALRSTAPRVQEAVLNCLRFCDRSGDYRAGLRLARRVRQNWGEFMDRADGRMLALASLEADLLRAAGRFQEAYEQSERTLGQLKANPHDELAELTARSAVANGLRHQGRYHDAHHIQQEVLDRTVWLVGTDDPLVLAARHDLAATLRALGRYREAYENDLMTLARREDLLGGHHLAGLASANAVTRGQRLLGMYGAALSRQAEVARRHEEALGARHPRTLDADIELALCRRHGDPGGPDGGTSLAGLVDRSVEIHGREHPVTLQCLSLHADALREQGDLGRARALGAEAETGYRALLGPAHPVSLGAVANTALVLLDSGQHSAAVAMLESARAGLIPALGQDHPWVLGCDLNTAAAYRQEGDLVSAVALSRDALSRSQAVLGAEHPLTLSCQLALAADLRGLPLREDDEALVLEEDAVNRLAAALGPQHPRTLAARRRVRPVWSFEPYVD
>NZ_CP029196.1|WP_150160372.1|2395353_2396154_+|DUF3097-family-protein
MRSYDPDLTPPWKKTAPVPEVPADRDLVVEEVTTGFCGAVIRCEAGTVTLEDRFGKHRVFPLDPRGFLLEGRVVTLVRPSAGPARPTRTASGSVAVPGARARVARAGRIYVEGRHDAELVERVWGDDLRIEGVVVEYLEGVDDLPAIVAEFAPGPDARLGVLVDHLVPGSKESRIAARVTSPDVLVVGHPYIDVWEAVKPSSVGIRAWPRVPRGQDWKTGVCEALGWPPNTGAAWQHILSKVTSYKDLEPELLGRVEELIDFVTAP
>NZ_CP029196.1|WP_015033539.1|2394614_2395343_+|MBL-fold-metallo-hydrolase
MDVDWEAYGWERLADGVGRRRLPGWDATVGLVLGERAVLLYDTGSSLAEGAELRTQIAGLTGGRRVTHIALSHPHFDHVLGTAAFAGAEVFGAVGSDELLGRAREREALREDAVRQGLDATAAAEAADVLVAPRHVVSGEWTLDLGGRQVLLANVGPGHSGHDLALLVPGSREVVFCGDLVEESGEPQAGPDAIPARWPDALDRLLGLGGEDAVYVPGHGAVVDAPFVRLQREELARRFSVA
>NZ_CP029196.1|WP_015033538.1|2393444_2394464_-|heat-inducible-transcriptional-repressor-HrcA
MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHKLGVSPATVRNDMAVLEEEGFIAQPHTSAGRIPTDKGYRLFVDRLAGVKPLSTPERRAIHNFLDGAVDLDDVVGRTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARLMLVLITDTGRVEQRVIDCPAPFGETSLADLRARLNSRVVGRRFADVPQLVQDLPESFEETEDRATVTTVLATLLETLVEEHEERLMIGGTANLTRFGHDFPLMIRPVLEALEEQVVLLKLLGEAKESGMTVRIGHENAHEGLSSTSVVSVGYGSGGEAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES
>NZ_CP029196.1|WP_015033537.1|2392307_2393444_-|molecular-chaperone-DnaJ
MATDYYAVLGVRRDASQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQVYDLGGDPLSASGGGGAGGFGAGGFGNFSDIMDAFFGTASQRGPRSRTRRGQDAMIRLEIDLNEAAFGTTKDIQVDTAVVCTTCSGEGAAPGTSAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRVRSRRTLTVKIPAGVDNGTRIQLAGEGEVGPGGGPAGDLYVEIHETPHETFQRRGDDLHCTVTIPMTAGALGTKVPLQTLDGVEEIDIRPGTQSGQSIPLHGRGVTHLRGNGRGDLIVHVEVQTPAKLDAEQERLLRELAKLRGEERPTGQFQPGQQGLFSRLKDAFNGR
>NZ_CP029196.1|WP_015033536.1|2390946_2392026_-|nitronate-monooxygenase
MSSTALNDLSRFPIVQAPMAGGASGPELVGAVCSAGALGFLAGGYKTAGGLYQEIKQVRGLTSRPFGVNLFMPQTGRPADPAAVEVYRHQLAGEATWYETPLGETDDGRDDAYDAKLAILLEDPVRVVSFTFGCPTPEVLASFARVGTFTIVTVTSAEEALAAQQAGADAVCVQGAEAGGHQGTYRDDPADDAPGTGLLALIAQVRESVALPIVATGGIMRGAQIAAVLAAGATAAQLGTAFLCCPESGAHPLHKRALTDPLFTRTAFTRAFSGRPARGLVNRFMREHGPYAPAAYPEIHHLTAPIRKAAATAGDAQGMALWAGQGHRLARELPAGQLVEVLAAELDTALSELAHRSAS
>NZ_CP029196.1|WP_015033535.1|2390206_2390950_-|16S-rRNA-(uracil(1498)-N(3))-methyltransferase
MTAPVFVVDAVPGPGSFLLDGPEGRHAVSVKRLREGEELVLADGGGRWAACVVLAAEGKDQLTVRVDEVHEDPAEEPRITVVQALPKGDRGELAVETMTETGVDAIVPWAASRCITQWKGDRGLKALAKWRSTAREAGKQSRRSRFPEVAEPMTTKQVAALLAGADFAAVLHEDRDHPSGALATAELPAKGAIVLVVGPEGGVSPEELAVFEAAGAKPYRLGRSVLRTSTAGTAATALVLGRTGRWS
>NZ_CP029196.1|WP_150160371.1|2388741_2390088_-|tetratricopeptide-repeat-protein
MADESPLIRSLRAAVTAAPGDVPLRLHFAELLLAEGRNDEAVAEAAVALQHAPGDTDARALMVRAMGMPPATPPAQAPATPPAQAPAPATPPAPAPAPTERATGPVEPPPPPVGPVPAFDWDAAEQQVRDVVGPRFLDDPQAAEGEGTAGDADAWDVDAPGSVRLADVGGMDEVKERLEAAFLAPMRNPELRKLYGKSLRGGLLLYGPPGCGKTFIARAVAGELGANFLTVSLSDVLDMWIGASEKNIHDIFETARRQAPCVVFLDELDALGAKRSRTHHSGLRNVVNQLLTELDGIASGAGNEGVFVLAATNVPWDVDIALRRPGRLDRTLLVLPPDATAREAILRYHLRERPIEAVDLGKLVKATEDFSGADLAHVCETAAEAALLDSARSGSVRLISTKDLLTAAKQIKPSTEPWFAAARNVAMFANEGGLYDDLLAHLKRKRKL
>NZ_CP029196.1|WP_150160370.1|2387650_2388745_-|tetratricopeptide-repeat-protein
MTTPAALLRAEALYDTGRYAQAGELVAQHLAGEPEDAEALVLLARCHHRAEDQPAALDAVDRALRAEPELLMAWLMRVQILLGLRRFQDAEAAARYAVQLAPQYWGTHYALGTALAQFAEHARTPARTREAYEAARAAVSLAPEEDAAHFLVGLTAQRRGDHATAQRAYETTLRLNPQSSEAHNNLSLLRLRRRWFRRGAWTQAAEGFVASAALDLQDRKARYNLEAMAWNTAAGARWVALVGFLASAVAGAAVPDGATWAEAAVPLLVGLAVLLGAWTGWAVWIGRRVPPRLRRPMLLVARNCRPVLFMAGAVGLLGLSSLSSLALWSFDSGVVRAFGTPLFWGVIITYWVSRSFLNRRAPKD
>NZ_CP029196.1|WP_041662374.1|2387209_2387569_-|histidine-triad-nucleotide-binding-protein
MAGEPQSDCLFCKIVAGEVPATIVRETETTVAFRDINPQAPTHVLVIPRLHYPDAASLAAAEPAVAADILREAGEVAAQEKVDGSGFRIVFNTGAGAGQTVFHAHAHVLGGRGLNWPPG
>NZ_CP029196.1|WP_150160374.1|2400723_2401965_-|coproporphyrinogen-III-oxidase
MGLMPSVLPDGETVPDDGALPPHALEGAGERPLGFYLHVPYCATRCGYCDFNTYTASELRGTGGVLASRDNYAEQVTEEIRLARKVLGDDPRPVRTVFVGGGTPTLLAAGDLVRMLAAVRDEFGLADDAEVTTEANPESVNPAYLAELREGGFNRISFGMQSAKQHVLKILDRTHTPGRPEACVAEARAAGFEHVNLDLIYGTPGETDDDWRASLDAAIGAGPDHVSAYALIVEEGTQLARRIRRGEVPMTDDDVHADRYLIAEDVLSGAGFDWYEVSNWATSEAGRCLHNELYWRGADWWGAGPGAHSHVGGVRWWNVKHPGAYAAALAGGKSPGAGRELLSDEDRRVERILLELRLKEGVELSLLKPAGLAAAAKALTDGLLAPGPYETGRAVLTLRGRLLADAVVRDLVD
>NZ_CP029196.1|WP_015033544.1|2402046_2403924_-|long-chain-fatty-acid--CoA-ligase
MSDTQTQIENRPPSVATLFLERVERTPDAEAYRYPVPAASGAGPDDWKSLSWGQAAERVYAIAAGLVDLGVASEERVALASATRVEWILADLGVMCAGAATTTVYPQTNAEESAFILSDSESRVLIAEDAAQLAKAVERRADLPNLRHVVVIDATGVESDGDFVLTLAELEARGKGYLEKHPEAVKERVAAITATQLATLIYTSGTTGRPKGVRLPHDNWSYMAKAIAATGLVTQADVQYLWLPLAHVFGKVLTSGQIEVGHVTAVDGRVDKIIENLPVVQPTYMAAVPRIFEKVYNGVAAKARAGGGAKYKIFQWAAGVAREYAKATQDNFRRTGTATAPFGLTAKHKVADALVYAKIREAFGGNLRACISGSAALAPEIGYFFAGAGIHILEGYGLTETSAASFVNPGEAYRTGTVGKPLPGTEVRIADDGEILLRGPGIMEGYHGLPEKTTEVLESDGWFHTGDIGELSADGYLRITDRKKDLIKTSGGKYIAPAEVEGQFKAVCPFVSNILVHGADRNFCTALIALDEPTLLGWAAEHGLGGKPYAEIVAAPQTVAMVQGYVDRLNEGLQRWQTIKKFRLLPRDLDIEHGELTPSLKLKRPVVEREYKGLIEEMYAGSRES
>NZ_CP029196.1|WP_015033545.1|2404119_2405985_-|elongation-factor-4
MPATPTNVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVDQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPTEGPAQGDTHILNMIDTPGHVDFTYEVSRSLAACEGTILLVDAAQGIEAQTLANLYLAMENDLTIVPVLNKIDLPAAQPEKFSEELANLIGCQPEDVLKVSAKTGMGVEALLDRVVRDVPAPVGVADAPARAMIFDSVYDSYRGVVTYVRVVDGQLNKRERIRMMSTGATHELLEIGVSSPEMTSSDGLGVGEVGYIITGVKDVRQSKVGDTITSLHQGATEALGGYKDPKPMVFSGLYPLDGSEYPDLREALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVIRERLEREFGLDLIATAPNVVYRVVMEDGSEHTVTNPSEFPEGKINDVYEPVVRATILAPSEFIGAIMELCQTRRGTLIGMDYLSEDRVEIRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQASSLVKVDILLHGDKVDAFSAVTHKDAAYAYGVRLVAKLRELIPRQAFEVPIQAAIGSRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGSVEVPQEAFIAVLSSDESGGKKK
>NZ_CP029196.1|WP_030317512.1|2406168_2406435_+|30S-ribosomal-protein-S20
MANIKSQIKRNKTNEKARLRNKAVKSSLKTAIRKAREAVAAGDVEKATVASRAASRALDKAVSKGVIHKNAAANKKSALATKVAALQG
>NZ_CP029196.1|WP_150160375.1|2407002_2407992_-|DNA-polymerase-III-subunit-delta
MATRKTSPDDLLGPVTLAVGQEDLLLDRVVQSVVAAARAADADTDVRDLTPDQLQPGSLAELSSPSLFAERKVLVVRNAQDLSADTIKDVKAYLDDPVEDISLVLLHAGGAKGKGLLDAARKAGAREVACPKTTKPAERLTFVRQEFRTLGRSATPEACQALVDSIGSDLRELASAVAQLTSDVDGTIDEAVVGRYYTGRAEASSFNIADRAVEGRTAEALEALRWSLSTGVAPVLVTSALAQGVRAIGKLSSARGGRPADLARELGMPPWKIDRVRQQMRGWTPDGVSLALRAIAEADAGVKGGGDDPEYALEKAVVAVARAARMRRG
>NZ_CP029196.1|WP_041662379.1|2408068_2408311_+|hypothetical-protein
MSERHVLVLPDRDSAEELAGELPDRFGVAEEPQLVRDSLAGEDDAEDAQWLVVVEDPDGRLDAAALDELAAEYEGWLEAP
>NZ_CP029196.1|WP_150160376.1|2408365_2409256_-|hypothetical-protein
MFDRLFGKRPAGAARGGPLAGLSVPASAGVVSCRVLDPVHEPVRRAEFLLSDTAGRKVLAGETDPYGTALATVPAGEYRLAVTAEGYTPHHGSAVVAEGGHTGLGDVLLQIAPQPQLPEPGDWEIDPTHSQIGFTARHIGLARIHGRFNSFAGAVRIADRMERSAMHVVIDAASIDTGVQMRDDHLRSSDFLDVGAYPTLEFYSERFTHKGGSRWAVTGALTLHGVSRTVTLDTQYLGIGSGLEGETRCACRATTELHREDFTLTWQTLLARGIAAVGSSISIDLDVQIVPKVTRG
>NZ_CP029196.1|WP_150160377.1|2409375_2410221_-|arylamine-N-acetyltransferase
MTTRPTAPVPPESFVPTPADVEAYLRRIGAARPDREDSDALRELQLRHLRTVPFENLSIHLGEAVVLDEKALLDKVVGARRGGFCYEVNTAFAVLLRGLGYEVSLLQARVFGEGGKPGIPYDHMALLVETADGRRRLADVGFGDHSHYPLDFDDRGEQQDPGGVFRIVEGVEGDLDVLRDGKPQYRVERRPRELADFAAGAWYHQTSPDSHFPRSLVCSLLSEDGRITLSDRKLITRAGGEREERTLESEEEVRGAYRELFGIELDVLPVVRGGIPDSNPR
>NZ_CP029196.1|WP_150160378.1|2410260_2411532_-|MFS-transporter
MSRVALVDRVPALLRERTFRRYWTGQTVSLAGDQISLMAIPLAAVLVLEADAAAMGWLKAAELLPALLLNLPFGAWADRQASRRRAMIATDLGRAGLVLSLPVAYALDALTLTQLYVVAFGIGALTVLFEVCNTTLFVALVPTERYVQANSLVNGSRSTAWLAGPGVGGLLVQFLTAPFALVADALTYLVSAGYLARIKPDEPPPAPVAKGHFTEGLRWVIRERSMRALFAASGTVQFFNYMFHTLFVIYVTTELGISPGLLGLVLGTGAVGGLLGAVLSGAVVRRIGIGGSLVAGFLGFTLPLVLIPLADGPLPFVVSVLFVAEFLSCVGVMIVDVAAGSFQMALIPDAVRARVMGAFRTLNHGFRPLGALVGGFLGTVIGLRPTLWIATVGAVFAVLWVLASPLARMRELPSPEEESAPVG
>NZ_CP029196.1|WP_150160379.1|2411528_2412152_-|helix-turn-helix-domain-containing-protein
MQEESSDQRPEGEQPRSIRLTDPRALRAYAHPLRLSLVGLLRSSGPFTATRAAELTGESVASCSYHLRILAKYGLVEEAPGGRGREKPWRATARYTEWPEYSDDAAVAQAAGALTAVVAERYFERVVRAMGNRHRLPKEWQEAEQFGDSLLYLTHEELADLGARIEALLRPYEARESDPSLRPEGAGPVSVLRVAYLDLDVPDREKE

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Crispr_ID: NZ_CP029196_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_7

3010174-3010321

Orphan

Consensus_repeat	Method
CCGGCTCCCGCCCCGGCCGTCAAGCCCG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP029196_7

>merge|NZ_CP029196|7|3010174-3010321|CRISPRCasFinder
CCGGAGTCGGCCCCGGCCCCGAAGCCCGTCCCGGCCGTCAAGCCGGTCCCGGCTCCGGCTCCCGCCCCGGCCGTCAAGCCCGCCCCGGCCCCGGCTCCCGCCCCCGCCCCCGCCGTCAAGCCCGCCCCGGCCCCGGCTCCCGCCCCCG

>NZ_CP029196|7|5|3010174-3010321|CRISPRCasFinder
CCGGAGTCGGCCCCGGCCCCGAAGCCCG	TCCCGGCCGTCAAGCCGGTCCCGGCT
CCGGCTCCCGCCCCGGCCGTCAAGCCCG	CCCCGGCCCCGGCTCCCGCCCCCGCCCCCGCCGTCAAG
CCCGCCCCGGCCCCGGCTCCCGCCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150160666.1\|3008854_3009910_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379258
NZ_CP029196.1\|WP_150160667.1\|3011135_3011588_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|171499
NZ_CP029196.1\|WP_150160673.1\|3025908_3026592_-\|DUF1524-domain-containing-protein	unknown	unknown	gnl\|CDD\|377857
NZ_CP029196.1\|WP_150160660.1\|3003454_3003967_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP029196.1\|WP_150160671.1\|3024615_3024954_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160662.1\|3004883_3005870_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|236612
NZ_CP029196.1\|WP_150160663.1\|3005979_3006471_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319910
NZ_CP029196.1\|WP_150160672.1\|3025098_3025848_-\|N-acetyltransferase	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160669.1\|3013028_3023828_-\|Teneurin-1	unknown	unknown	gnl\|CDD\|379155
NZ_CP029196.1\|WP_150163598.1\|3026681_3027554_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150163597.1\|3001143_3003444_+\|YfhO-family-protein	unknown	unknown	gnl\|CDD\|370572
NZ_CP029196.1\|WP_150160659.1\|2999172_3000138_-\|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|237065
NZ_CP029196.1\|WP_150160668.1\|3012293_3013016_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160665.1\|3007838_3008735_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|369561
NZ_CP029196.1\|WP_015034107.1\|3000157_3000802_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372652
NZ_CP029196.1\|WP_150160670.1\|3023995_3024619_-\|BMP-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380577
NZ_CP029196.1\|WP_150160661.1\|3003963_3004698_-\|DUF2625-family-protein	unknown	unknown	gnl\|CDD\|371310
NZ_CP029196.1\|WP_015034118.1\|3011660_3012059_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160664.1\|3006562_3007789_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP029196.1\|WP_015034116.1\|3010485_3011139_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150160666.1\|3008854_3009910_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	4.39579e-07
NZ_CP029196.1\|WP_150160667.1\|3011135_3011588_+\|hypothetical-protein	gnl\|CDD\|171499	PRK12438, PRK12438, hypothetical protein; Provisional.	0.000536953
NZ_CP029196.1\|WP_150160673.1\|3025908_3026592_-\|DUF1524-domain-containing-protein	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	3.66937e-32
NZ_CP029196.1\|WP_150160660.1\|3003454_3003967_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.36323e-19
NZ_CP029196.1\|WP_150160662.1\|3004883_3005870_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|236612	PRK09685, PRK09685, DNA-binding transcriptional activator FeaR; Provisional.	2.88926e-25
NZ_CP029196.1\|WP_150160663.1\|3005979_3006471_-\|VOC-family-protein	gnl\|CDD\|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	9.84659e-41
NZ_CP029196.1\|WP_150160669.1\|3013028_3023828_-\|Teneurin-1	gnl\|CDD\|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	1.08415e-26
NZ_CP029196.1\|WP_150163597.1\|3001143_3003444_+\|YfhO-family-protein	gnl\|CDD\|370572	pfam09586, YfhO, Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	1.15318e-62
NZ_CP029196.1\|WP_150160659.1\|2999172_3000138_-\|nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|237065	PRK12334, PRK12334, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	6.90852e-108
NZ_CP029196.1\|WP_150160665.1\|3007838_3008735_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|369561	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.53408e-82
NZ_CP029196.1\|WP_015034107.1\|3000157_3000802_-\|hypothetical-protein	gnl\|CDD\|372652	pfam13624, SurA_N_3, SurA N-terminal domain. This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	2.80017e-08
NZ_CP029196.1\|WP_150160670.1\|3023995_3024619_-\|BMP-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380577	cd06354, PBP1_PrnA-like, periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea. The PnrA lipoprotein, also known as Tp0319 or TmpC, represents a novel family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC) transport system (pnrABCDE). It shows a striking structural similarity to another basic membrane lipoprotein Med which regulates the competence transcription factor gene, comK, in Bacillus subtilis. The members of PnrA-like subgroup are likely to have similar nucleoside-binding functions and a similar type 1 periplasmic sugar-binding protein-like fold.	5.04389e-09
NZ_CP029196.1\|WP_150160661.1\|3003963_3004698_-\|DUF2625-family-protein	gnl\|CDD\|371310	pfam10946, DUF2625, Protein of unknown function DUF2625. Some members in this family of proteins are annotated as ybfG however currently no function is known.	1.4311e-101
NZ_CP029196.1\|WP_150160664.1\|3006562_3007789_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.75406e-53
NZ_CP029196.1\|WP_015034116.1\|3010485_3011139_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	2.93677e-30

>NZ_CP029196.1|WP_150160666.1|3008854_3009910_+|LysR-family-transcriptional-regulator
MEALAVRLSGLDPYVDGALRIVAFYDTLMRRRVDLPALARASAGLAECVTGIGLHGTGRSIRLAPDGREAAGPAAPASGAVPVVLDEEEIGTVWLERAGPAGPLDEVLLDRLALAVAGAVERYGPARTTMADPALVELVVSTGTDEAARARALRLLGFAAGSPVRVAAVRSPRLPLDRVGAAVCPGRPVKAARIGGVGVVLAAAVDPARFPAGVRAGVGAADGPDLAWREARTALRLTTEREPVVLHAELGALALLAEVPTEALRANPDVAALVRLAGQEAPQEVRELLDTLDAYCAAGSLRRAAEALHLHHSSVSRRVDLLGKALSVDLTTPTGLTRARLALTSWRLLNN
>NZ_CP029196.1|WP_150160665.1|3007838_3008735_-|alpha/beta-hydrolase-fold-domain-containing-protein
MDPELEAFVPFFPRTDLTDPVTARQNFAQLAAAVPAPDTTGMDIEDRTVPADPPVRVRVYRPHRARGAVVWLHGGGFLMGDLDTEHPWAARIAASSGAVVISVDYRLAPEHPFPAALDDAYAVLTWAVGHAAELGVEPDRVAIGGHSAGANLAAAVTLLARDRQGPPIRFQLLNQPGLDDRQDSWSAVNFTETPWFFRAKSLASWRHYLGGGPATAYAAPARAEDLAGLPPAYLATAEFDPNRDEGLAYALRLLQAGVSVEIHQWPGAFHGSQAILSAEISQRQNEELGAALARALAG
>NZ_CP029196.1|WP_150160664.1|3006562_3007789_-|serine-hydrolase
MKLRSKIRLALVTGVAALTACAGTVAAAPAPHPPQAGPARQDPARLDPARLRDAMDDVHRAGVPGVFGEVRDQGRTWRGASGVADLATGRPVSPGMRQRVGSITKTFTAAAVMRQAERGRIRLDAPVGDYLPDLVPGERGRKITVRMLLNNTSGIPDYIPYAFPSLQRNSPTSLDDNRFREFGPDELIALGLAAPPTGEPGGPVGVYSNTNWLLLGRLLERVTGTTAERVITRDVIERAGLRHTGFPDGPTIDGPHARMYESLWGLLDPPRDYSVYNMSWTGTGAALVSTMDDLNRFYARLLDGGIVSRSSLAQMQRTVPVRALDGTMIEYGLGLHKVVVPGCGTFWGHDGTVWGAGTLSLTRADGRRQMSIAVNLQRWSPREAGGTLPPHPIDTALKTLSDRSLCGS
>NZ_CP029196.1|WP_150160663.1|3005979_3006471_-|VOC-family-protein
MSVKPVPEGYHTVTPWIISPDTRRLIGFLEAAFGAEELSCLVGEDGSVGHAEVRIGDSVVMMFDARPEWPATPGFLRLYVEDADATHRRAVAAGGTSVTEVTHLFFGDRVGRVRDPLGNLYWIQTRVEDVTEEELERRLGDPEFTKAMEYVQGADFFPGRSVG
>NZ_CP029196.1|WP_150160662.1|3004883_3005870_-|helix-turn-helix-domain-containing-protein
MWSVVSSGDLPDGERFEWFADMISREVMPTRLTSERPAEFTADAALLDLGELQVSEVAYAPLRSQRTPALIRRGDPEQYQLGLVTKGAMTLVQHGNSCEAEVGDLVFWDTSRPSDARYVSDGDPGQLVILQLPRDVLPLPAKRLDSLLARRMPGGSGVGAVLVAFLRSLVAHGGECAPDELRRIGSTAVDLAAACLAQHTDAEEQLPAEVRARALIRRIHAFIEYNLGDPELSPVAVAAHHNMSVRALHQLFRGEGETVQARVRRRRLERCRADLLRPELLTYPVQAIAARWGFSGPAVFSRSFREAYGVSPTELRARALAGEDSRLR
>NZ_CP029196.1|WP_150160661.1|3003963_3004698_-|DUF2625-family-protein
MRELSELTEVEDPAWPVLGEELRAASVPVEVLDPDGERGAAALLRTQVTVRSFLGAFLLHSGGAFVDDGWLRVYGSPADDNDRRLPSLARVNGYPADAAAEPGWRPGAGLVVAHDVLGGVFVLQGGPAEEVGLPGRPGEMVYFAPDSLRWDALGAGYGAWLSWMLAGGTEEFYEGLRWPGWREEVRRLDGDRGLTLYPPLWSEEAHRDLAATSRRVVTMAEVLGFERETAVGLDEPDPGFLGNV
>NZ_CP029196.1|WP_150160660.1|3003454_3003967_-|GNAT-family-N-acetyltransferase
MSAADDGATVRTDRLDLVPLAVAHADEMAVVLADPALHVFIGGAPLTPPELRARYGRLAAGSPDPGVRWRNWVVRLRAEERLTGTVQATVTDGGRVAEVAWVIGTEWQGRGIATEAARALTALLVSEGARLLVAHVHPAHPASAAVARAAGLTPTDRLEDGEVRWERRVV
>NZ_CP029196.1|WP_150163597.1|3001143_3003444_+|YfhO-family-protein
MLLAGLLTVLAVCGGDAVARVFPFGPRHRAVNDLANQFVPFHAHLWDLLRGRADGGLLLDWQAGWGTSFLPDYGTYVSSPFAPLVALFPRGDIEYAVYGVTVLKTAVAAAAMTFLLRRLGPGTWWWASVLGASYALCGWSLAEGTYNPMWLDGLIAFPLLCLVGEWVREGRRPLLGPLVVAVCWVANFYTAYMATLGAALVLLVRLAVTDQEDGGRVRTVLRAALTTGIGIALSAPVLVPVFLGSRHAHPGVVRDFVPAPATDVLARLLPATYSFSTPAAFVCTAVPLLVAVLLFRRDVPGPERWLWPGLCAAVLASLQWGPTHLLWHAFATPNGSPYRQTFVLSGVLVLAAWTGLAHGLPDRRALLGGTAVVAVLTLGSLPSPFLTSWALLLTAGGLAAVTGALLLPKRGRYGLLAALLVAGTLVGQAAATTAYADRERLVRLDDYPPWGAEHERRAAALAVADGWPAYRTDPGLPRVAGNDPLLLGGQGAAYYSSHTPAVLTGTLAALGGGWTSRGRNLLSLDNPVTDALFGVGARWRDGRVVRSEPLPLVTVRPPGPPPVYGGSPFRNQELLLGARVYEAPGPGGACPVGTEVFLWAPNATGTARLGGYETRLLGGGPKRRAALTSLGVQRRPGLTARVPPGGTSEIACLDHDRLRTAVTALRARAATRTAVHADGLTATLPPGTTGTAVVAAPAIAGWRCGGATPTPYGGLLAFPVAPGTTTVSCTFRPPGLTPGLAAGAAGLVLLAGRVWLGRRARRQRAA
>NZ_CP029196.1|WP_015034107.1|3000157_3000802_-|hypothetical-protein
MHRRTALTVSAALLAAGPLLTACGGDAHPGAAAVVGGERIDVSSLQAQVEDVRAAQERSPQAAQLVQATGDLPRRKLNGMIFDRVVDKVAADHGVTATRAELQQTRTAFVRESGGEERLASVLLQEQGVAPGQIEDVVRRNVLMNKIAAKLGVTDSPEGQKKLTDVFSAASKSLAIDVNPRYGAWDDAQVRLADSTEPWLRQLSQDPAAVPAGA
>NZ_CP029196.1|WP_150160659.1|2999172_3000138_-|nucleoside-triphosphate-pyrophosphohydrolase
MTSESPGRIVLLTASHRVAPGLLSWPAWQALHGADRVLCPDEHHPQLPYLREAGVAVEHARPTAEELVEACAGGRTVLLLPSGEGDRRLTDGLARLAGSGRFTMPDLELLPGSYDLPGARLLDLVQIMDRVRRECPWTSQQTHRGLAKYAIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEDPEEPFSVDDVAGTLAEKLILRHPHVFGDAEARTPEDVRAHWLRTKEIEKRRESVTDGVPLGQPALALAAKLGGRARTAGLDVTVPAGQGVGYELLTLAVRAEAAGVDPEAALRAAARAYRDAIRAAEGVHA
>NZ_CP029196.1|WP_015034116.1|3010485_3011139_+|sigma-70-family-RNA-polymerase-sigma-factor
MQLSYAVPVPVPPPAAAARPPWWARLLARVSRAEDAPAAVRGRHLYAVGASGDPGPPPDLTELYLARRLDMVRLAVFLVDDRHTAEDVVQDAFAAMCRRYGTSLHGLQDPGAYLHTAVVNAARSVLRRRRTARAYTPPHPVAGPPVDEDLLLAEEHRHVLDALAGLTRRQREVLVLRYWSELTEAQIAQTLGLSRGTVKSTASRALDALEKKLEGGR
>NZ_CP029196.1|WP_150160667.1|3011135_3011588_+|hypothetical-protein
MTPSGPRAGAGDAPGRHTVTEERLRAAFAARAALVTYRDLRREEPPRGRSRGTRRVRGFVLAGLGSVAAAAAAYALFLGPGGGAATPPPVLPARPPGVGVPSPEVPGPTPGPVGPSVARPRPSTPEGVPGARPEELPGLPQRPPGPAARP
>NZ_CP029196.1|WP_015034118.1|3011660_3012059_-|hypothetical-protein
MTTPSAPQTPEQPFAAEQPAAPAKKGSRILKKVGGVVVAIAVAIAVKFGLPHLTGDAPVHAKAGECVTVTGPDNDPKVDTTDCSSGKADLFKVVKVIDDTFDVNKCGAELSALAQQLESDKFVLCLEEVPAK
>NZ_CP029196.1|WP_150160668.1|3012293_3013016_-|hypothetical-protein
MAFDVERAVREIPNVEEFPGLARAWRWSPMFRFVFSLAMNAEGTRIHQVNARDSFDEALARAVLTFAREHRAGLGDDPRPFEVVPGFSHPGYDFDAVVAIQPEIHGYYVGRNEELNEVVVGVFPAYVREFSGNETPEEAFFRFKRMLNAADMTREAAPFLRMRFDNTRTGGGSEGDLRGFTTPDVLLRELALLEGAPGSFLEYENRHGRVWRIEWNGSWTVDGEAREHAPAAAEVLETLN
>NZ_CP029196.1|WP_150160669.1|3013028_3023828_-|Teneurin-1
MRIRRVRSPHLFPPGRTGRRRLRATALSVLISLFLMLTTESAVAAGVTLEPVKMPKLSLAGLWKWVSENPLDTPDQQGGTARGKSHHASADATSLEGAAGRKPGKGKGELPLYERKTDDPAEVRSGKAPGTAHSFDARTSRRDAKKSTATSDFYVNADGSTTVRHYPGRTNFKGADGTWKAIDTSLTEDKDGRLQQTANSLDVEFAPTAADKALASVDFGKGRTFAYALRDAAKTEPTVDAHGTVTYAGVLPETDVQLVPLAEGFKENIVLRSPRAGNSWVFALDLKGLTARVAADGDVEFTDADGKVTATVPHAYMEDSKVDPRSGDRAQSRAVTYELTTVDGKADGQPALRMTADRAWLDDPARVYPVTVDPTVTASNSTYTQNTIGGDHSTETQIKVGSYDSGTNKTNSFLQFSSLGTALAGQRVTAATLNVYALWSSTCAAQSFSVHPITQSWTPSAVTAYPGPSFGAAIGTATPAPGASCSNTGNSASVGVRMPVSLNTTWFNNVAGGAANYGLALTAPTNDMLHWKKFHSDNSATAGFRPALDLTYTPNSAPQINAQYPPANFQANTLQPELLVYASDADKGPSPLSYTFEVYDGDATGTPTLVASSGTVTKGSWKVPAGKLKWSKNYDWYVEASDGTSAVVEGSSFTTAVPQPPVTSGLSMNTDGHEFDPSDGNYTTEDTDADVPVIGPSLEIERSYNSLDPRVDSAFGAGWSTIVDMKAVEVKDGAGALTSVIITYPGGEQVAFGRNSDGTFVPPLGRYARLAAVTGGYTLTDKDFTEYAFTQATAKTGTYALKTIKDYAGRTETFTYDANKRLTKITNEVSKRNLGLTWYQPASATAWHVQTVYTDQATAGDANSVQTWQYTYTGDQLTKVCPPADWSKCTTYTYATGNHYRTTVLDADPFAYWRLGETSGTVAKDALDANQGQYNGTYKNVTLGGTGPLAGSTQKAATFNGTTSYVEMPAAPGATPSYTSVSLWFKTTTAGGVLFYYGDKPLSDPDPVANTTKNTPAVYVGTDGKLRGCLAMSPGCMTTITSTPVVTDGKWHNAVLTGIANSQTLYLDGAAVGSLGGTINDWVQPYISLGAGVNTSGWPAMNANDKLGHFNGQLAEVAIFSEPLAADVIKSQYDSATRPAGLLEKITTPGGKTQASVVYDTTDDRVLQATDGNGGTWKLNPPTITGSSQVYRSAVMGSAPAGYWRLDDTQGAAQAANQVNTGFGTYNNVIQGAEGPFGPGDASAATFDGATSFLEIPYGPLHAKADRSVELWFKTAEPGVLMSDQSVAPNNAAGAAGSWSNLLYVGADNKLHGHWWSSTCNGAATLGSTAAVTDDKWHHAVLSAAGTTQTLYLDGAKQGTCTGAPSDQTTSRTFVGAGFGKNWFSSPADVSYFTGSIAEVAAHAKGLTDADVAAHWSAYKASSGIAPVKTVKLTDPTDKTLTYVYDAEMGNRLLAAIDTEGDRTTYGYDTGGFLHTITDANGNRSITGHDVRGNTVSQTTCQNTAANKCSTEYYTFYPDATTAFPPMDLRNDLLLTERDGRSSGPTDNAYLTSYSYDAGGNLLSVTTPPVAGHPNGRTASTTYTTATTPAAEGGTAVTPAGLVAQVVTPGGRKTTYTYFANGDLAKITDANGATVEYTYDKLGREISKKEVSDANPGGLVTSQTYDKNDQVVTETTPAVTNRVTGAKHQAKTTTGYDPDGNILSQTVQDLTGGDTARVTSMTYDAHNQLATRTDPGGDTTSFEYDAYGNKVKETDPAGTVNTYTFDGEQRPLTTNLLNYTGDPYNPTPPTTLVQESRAYDPAGRLASITDSLGWQTAYTYTDDGLSASVVRKDPQTGKSFTEQANTYDAAGNLIEQVTNDGQTRTTFTVDAADRTVSEILDPNGLARTTQTSYDPDDNVVSETDRDPATGDVSTTDTRYDRLGNVTGTTSHDGTTAPVARYKLDETTGFGLADSSGANNTGTHGTGMHWNTDRGGSAVLDGDANSWAQSNGPVVNTNGSFTVSAWVKLTNTTANRTFVAQDGKEASGFQLYYSTAYGWTFNRHATDTYDPAIVRVSSGTAAVTANTWTHLVGVYDQASAQLRLYVNGVASGTPATFGTPWEATGPLQIGRRWYKGAYGENHLGGLDDVQVYSEALTAAQVTALKGGTLPAAGSSVRTTSWKLDQRGLPVSQTDTAGNVTDYGYDELGQQTSVTEPAVMAEQNGGTPVSVRPVTMTGYNTFGEATEYADPLGNVATTAYDAEGQESSVTTPEYLAPGATAPIRATSYNEYNKLGQVTAEVDALGNRTTYTYTQLGDLASVTEPGGGTTKYTYSTNGDQLSATRPNGARQEMTYDYLGRELTSTDIVRQPTQRAYTAINEYNAPGGELSRVVSPNGVSESYKYNAVGEMTEVTDSAGNVSRFTYDMDGQPLLSTDPDGTSTRNTYDGFGQLVKTEDLDETGAVLRTARTSYDRMGNAVSVTDYRQHTKTLTYDAAGQITKAVEPVSATESITSTFGYDAAGNRTRFTDGRGNPFITTYNTWGMPESVVEPSTPTHPNVADRTFTAVYDTIGRVKEARSPGGVTTSFEYDAKSRLVKQTGTGAEAATADHTYSYDEDDRLTAVAGLGTEKNTFTYDDRGLLLTANGPSGASSFAWNGDGEMTTRTDASGTSTYGYDTAGRLKTTNDGATGTTLTYAYDVNSNVKSIEYGTGKAKRSFGYDKLQRLTSDTLTSPTGKTLSSLTYGWDENDNMTSKTTAGVAGASANTYTYDWADRLTSWNNGTTTEVYGYDASGNRTRVGGDTYTYDARNRLTSDGHSTYTYTARGSLSSVTDDASRVTTMKTDAFNRVIQEGDRTYTYDGFDRVLTANEDGAAIHTFQYSGTDNDVASDGVSSYSRDADGSVVGVKTAVTAVLALTDLHTDVIAQFTATGEALTGSTTYSPFGKVVQSSTMLGALGYQSGWTDPQTAKVNMAARWYSPETGQFNNRDTASNSPLPDSVNANRYAYANGNPMTGTDPTGHWFDSIKKAFKKVTKKVKHVAKSAYKKAKKAVKHVAKVVKKAAKKVKRAVKKVVKRAKRAVRKAVRYVADSVRKVKRYVKRVYRTVKRVAHKVVKHVKRAVRKVAKAVKHVAKKVVKAAKKVGRAVKKAAKATAHFVKQHASTIASVATGIAVFAGCTAITAGVGAVGCAALAGAAANGVGYMMSDGPKSVGGFLGAVAIGAVTGAAGGVGGRLAASAAGKLLSGTAGKIATNVAESAGEEALTGAVEYGTSCVNSEEGCSVAGAAKAATIGAVMGGAFGAKGKGNGPKSKDSAGGSSGPGCPVRRSGTPHSFTAKTPVLMADGKTKKISEVKAGDKVLTAEPGKTTKEVHEVKRVIVTKTDRDYVDVTIAAKAGRKTIETTKHHQFYESTRNSWTQAGDLRVGQKLQNGEGAPAAIVEVTSYQADRTTYDLSIEGLHTYFVFAGDQIQAVDKSAAVLVHNCGGSNPAHSPTCTCAAGNQPRMANGNMGSNPNPNPSRLNRDNQYPSGYWADTHREMERNWKDSDGNWLDNDGNIVPDDELTYEHTYAVVDHWNAEGYNQSKSERAKFFNDASKMHPMRRKANSSGGGKMKARYRQDTGPNYSN
>NZ_CP029196.1|WP_150160670.1|3023995_3024619_-|BMP-family-ABC-transporter-substrate-binding-protein
MKTRRAWRATERQAAKKEAAESGAARVPGLLATGAAALRGRTGWVLGSVLVLALGLVGVRLFAGSDDAGTPPDTRARAYQDYDACLLTDERGIVTGAPAAPVWEGMQAASLNTRIRVTYVPVTGEKSAANARPFLNGLVQRDCEIVVASGAPQVEAVEAAVEKNPKVRFVTVDGAGGAGRDNLVRVASGASLKDDVAATVKRLAQEG
>NZ_CP029196.1|WP_150160671.1|3024615_3024954_-|hypothetical-protein
MNQAVRLEKGAVPARPKVLPGRPVRIGLALVPLLSLGVLGFVPSLTLALWRGTRADRLAAVLFAAVSVGWCLQIALTPEETHGFSYLLDVVLLAASTLGAAAHCLTVKESGR
>NZ_CP029196.1|WP_150160672.1|3025098_3025848_-|N-acetyltransferase
MDLNISTLAERPELEGPMWGMRDLWPEFMMYDPVGWANIGRIVRELPEYVLVATDADGKVVARGFSVPFRLDVDGRGELPARGWDEVLLWAFSDLKHGRAADTVSAIEITVDTDFLGRGISHRMLAAMRDNAGRHGFSELVAPVRPNGKHLEAGTSIHEYAFRTREADGLPHDPWLRVHVRAGGVVEAVAPASMTVSGSVEQWRAWTGLPFDADGPVEVPGALVPVHCEVSRGYAVYVEPNVWVRHSLA
>NZ_CP029196.1|WP_150160673.1|3025908_3026592_-|DUF1524-domain-containing-protein
MFTYRRTLASSALAVAVLVTSACSNGADAPESGGGAGKPAARGTALAAVDTLAVKGRAPKTGYEREKFGRAWADVDGNGCGTRDDILKRDLTGVRFTDGHCKVASGTLTVDPYTGTTVPYARGRSKVDIDHVVALSDAWQKGAQKWDAETRRRFANDPLNLLAVDASTNRRKSDGDAATWLPPNKAYRCTYVARQVAVKKKYGVWVTGGERDAMKRVLGGCPQQKLP
>NZ_CP029196.1|WP_150163598.1|3026681_3027554_-|hypothetical-protein
MWHLLEPLHALLYYAPEAFDEAAALGYDTTERWPSYFAWRAAPLGPAGPDRVADTFYSFSPAMIARYVPAAWDTAAPADVLAARVRAVDRTYRAVLGEELLASPELAEAAELARAAADAATAPAGAAAAPVDPVARPLAVANAALPRSEAPHLVLWQSATVLREHRGDGHLDAVVDAGLDPVESLVSFAAIGAAPEPLFASRGWSADEWAAARDRLAARGLVTADGTATEAGRALRAEVERRTDELAAAPWAALGPAGTARLAELLGGPWLAAIGSGLLPAENTLGIGKV

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Crispr_ID: NZ_CP029196_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_8

3229632-3229776

Orphan

Consensus_repeat	Method
CAACATGCACGCCACCACCGAGCCGG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP029196_8

>merge|NZ_CP029196|8|3229632-3229776|PILER-CR
AACATGCACGCCACCGACGCCCCGCTCGCCGACTCGGTCGCCGCGAAGCTCGGCATCAACGGCAACATGCACGCCACCACGGAGCCGATCGACGGCAGCGGTGGCACGGCCTCCACGGACAACATGCACGCCACGACCGAGCCGG

>NZ_CP029196|8|1|3229632-3229776|PILER-CR
AACATGCACGCCACCGACGCCCCGCTCGCCGACTCGG	TCGCCGCGAAGCTCGGCATCAACGGCAACATGCACGCCACCACGGA
GCCGATCGACGGCAGCGGTGGCACGGCCTCCACGGAC	AACATGCACGCCACGACCGAGCCG
G

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150160773.1\|3218118_3219573_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143408
NZ_CP029196.1\|WP_150160785.1\|3238022_3238904_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319911
NZ_CP029196.1\|WP_041662513.1\|3216305_3217880_-\|APC-family-permease	unknown	unknown	gnl\|CDD\|223605
NZ_CP029196.1\|WP_150160777.1\|3223501_3224419_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274680
NZ_CP029196.1\|WP_150160776.1\|3222728_3223490_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235546
NZ_CP029196.1\|WP_150160778.1\|3224560_3225778_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|368185
NZ_CP029196.1\|WP_150160771.1\|3215411_3215927_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP029196.1\|WP_015034300.1\|3231672_3232815_+\|lipid-transfer-protein	unknown	unknown	gnl\|CDD\|181147
NZ_CP029196.1\|WP_150160782.1\|3234047_3234608_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160780.1\|3232820_3233246_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224462
NZ_CP029196.1\|WP_150160775.1\|3221492_3222617_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|225052
NZ_CP029196.1\|WP_150160783.1\|3234735_3235377_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160781.1\|3233242_3234013_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP029196.1\|WP_150160772.1\|3216014_3216230_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160779.1\|3225997_3229342_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276938
NZ_CP029196.1\|WP_015034308.1\|3239233_3239881_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP029196.1\|WP_150160774.1\|3219569_3221309_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238622
NZ_CP029196.1\|WP_150160784.1\|3235404_3237885_-\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NZ_CP029196.1\|WP_015034309.1\|3240018_3240489_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|211538
NZ_CP029196.1\|WP_150163611.1\|3230013_3231582_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236072

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150160773.1\|3218118_3219573_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143408	cd07089, ALDH_CddD-AldA-like, Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins. The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid; and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and also, the Mycobacterium tuberculosis H37Rv ALDH AldA (locus Rv0768) sequence; and other similar sequences, are included in this CD.	0
NZ_CP029196.1\|WP_150160785.1\|3238022_3238904_-\|VOC-family-protein	gnl\|CDD\|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	8.86797e-23
NZ_CP029196.1\|WP_041662513.1\|3216305_3217880_-\|APC-family-permease	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	2.1007e-25
NZ_CP029196.1\|WP_150160777.1\|3223501_3224419_-\|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	1.66879e-68
NZ_CP029196.1\|WP_150160776.1\|3222728_3223490_-\|SDR-family-oxidoreductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	3.31004e-81
NZ_CP029196.1\|WP_150160778.1\|3224560_3225778_-\|amidohydrolase-family-protein	gnl\|CDD\|368185	pfam04909, Amidohydro_2, Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.	6.42266e-30
NZ_CP029196.1\|WP_150160771.1\|3215411_3215927_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.48087e-09
NZ_CP029196.1\|WP_015034300.1\|3231672_3232815_+\|lipid-transfer-protein	gnl\|CDD\|181147	PRK07855, PRK07855, lipid-transfer protein; Provisional.	0
NZ_CP029196.1\|WP_150160780.1\|3232820_3233246_+\|hypothetical-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	4.57876e-17
NZ_CP029196.1\|WP_150160775.1\|3221492_3222617_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|225052	COG2141, COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion].	1.5526e-43
NZ_CP029196.1\|WP_150160784.1\|3235404_3237885_-\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.57503e-74
NZ_CP029196.1\|WP_150160781.1\|3233242_3234013_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.81573e-36
NZ_CP029196.1\|WP_150160779.1\|3225997_3229342_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	9.40035e-42
NZ_CP029196.1\|WP_015034308.1\|3239233_3239881_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.43323e-10
NZ_CP029196.1\|WP_150160774.1\|3219569_3221309_-\|amidohydrolase-family-protein	gnl\|CDD\|238622	cd01297, D-aminoacylase, D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.	4.33107e-94
NZ_CP029196.1\|WP_015034309.1\|3240018_3240489_-\|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	5.50005e-26
NZ_CP029196.1\|WP_150163611.1\|3230013_3231582_-\|AMP-binding-protein	gnl\|CDD\|236072	PRK07656, PRK07656, long-chain-fatty-acid--CoA ligase; Validated.	0

>NZ_CP029196.1|WP_150160779.1|3225997_3229342_+|tetratricopeptide-repeat-protein
MDRENGPRVPVQRAPRTSAGAGPGTGPNTGNGTGTEAPAGAATAAGTEPAAGAATPGAGAATAEATGTDGATGATTASSAGTGSGQPSAGTGPGAGADPGTGTDSRTSSGSSTDSRAGTGATLGTGTDSRTGTGAGSAAPGAAASEAARPGLLRFAVLGPVRAWRDGEPVSTGSPQQRALLAALLLRGGRTATAAELIDALWGEEPPSQALAAVRTYASRLRKALGPQVLVSESGGYALRTSAAALDATTAQELGAEAEKLRAAGDRAGARDKLAEALDLWDGEVLASLPGPYAETQRTRLEEWRLSLLETRLDIDLELGAHAEAVSELTALTAAHPLRERLRELLMLALYRGGRQAEALAVYADTRRLLADELGVDPTPELSRLQQRILQADAELARPVEEAAPAAATVARPAQLPATVPDFTGRAAFVRELGDRLATAEGHVMAVSALAGIGGVGKTTLAVHVAHAARPHFPDGQLYVDLQGAGNRAAAPETVLGSFLRALGMPDSAIPDSLDDRAALYRSTLDGRRVLVLLDNARDAAQIRPLLPGTAGCAALVTSRIRMVDLAGAHLVDLDVMSPEEALQLFTRIVGTERVQSEREAALDVVAACGFLPLAIRIAASRLAARRTWTVSVLAAKLADERRRLDELQAGDLAVKATFELGYGQLEPAQARAFRLLGLADGPDISLVAAAAVLDLPLWDTEDLLEALVDTSLLESAAPGRYRYHDLVRLYARACADRDEQPPSEKEAALSRLLDFYLSTAAQVYAIERPGDRLVDHLEPTTHEGLTFTDRHAAQDWLYAEANSLLACVRQSAASPATLRRAVDLLWASLDLAESGANSREYETVATTLRDAASTAGDARAQGRASLTLAYVQHVAGRFDEADGEAHRAMDLAASTGDALPLCWAANALGIMALYQGRNDDGERFLTQATTSFRACDDEAGEASALCNLSRIHLAMGQTDIAVELAQRGTEMYDAMGHALKGANGRYALGLALTQSGRLDEAAARLTEALAVFRDSRQRLWEGMSLFRIAEVDIAARRYAQAASNSELALVILKGVGGEWRRGQALVVLGRGLSGIGQHGRARVCWQEALDIFVELGSADESDVRALLRETAAA
>NZ_CP029196.1|WP_150160778.1|3224560_3225778_-|amidohydrolase-family-protein
METFPKIISVDDHTVEPPHVWRDRLPSRYHDTGPRIVRAPLKEMTFLGGKFAPVMGARGDEGPIGDWWVYEDLHRPLTRLDTAVGYDRDEIRLEVITYEQMRPGSHSVPERLADMDVNHVQSALCFPTFPRFCGQTFTEAGDRELGLLCVRAYNDWMVEEWCGPEARGRLIPLTLIPLWDPELAAAEVRRNAARGVRAVAFSEIPPHLGLPSVHTDHWDPFFRACDETGTVIAMHIGSSSRMPSTSADAPPAVGSTITFANCCFSMVDWLMSGKFERFPNLRIMYAEGQIGWIPYILERADVVWEENRGWGGVAEKVLRPPSELFAGHVYGCFFDDAFGLRNLDAIGVGNVLYETDYPHSDSTWPKSREVGEAQMGHLAPDVVERIVRGNAIDLLGLTPDGLWRP
>NZ_CP029196.1|WP_150160777.1|3223501_3224419_-|TIGR03619-family-F420-dependent-LLM-class-oxidoreductase
MVVYGMQLPVQSQSAIYAEPWEAAAGTRDLVEIARAAEAHGFDYLASCDHVAIPRRLAEAMSTVWYDPVATLSFLAGVTERVRLLSHVAVVGLRHPLVTAKAYATLDHLSGGRLVLGVGAGHVQEEFEAVGVDFARRGAVLDETMDALRAALGPEEFPEHMGERFAFKDLGQLPRPAQERVPLWVGGSSPAAVRRAALKGDGWLPQGDPREQLAERIQQLLRLRADAGIAEPITVGAIAEPLYVGTPGWPVGRRTLSGSPEELAASLRAYGEMGVHQIQVRFRSRSRTELIDQMAAFGTEVAPHL
>NZ_CP029196.1|WP_150160776.1|3222728_3223490_-|SDR-family-oxidoreductase
MGKLDGRVVLVTGAARGQGEQEARLFAAEGARVVLADVLDEAVAALAKELGEERAVHVHLDVTREEEWAAAVAVAKERFGKIDGLVNNAGILRFNELLATPLEEFQTIVSVNQTGCFLGIRTVAPEIVAAGGGTIVNTASYTGITGMAGVGAYAASKHAVLGLTRVAALELAAKGVRVNAVCPGAIDTPMSNPEGVDPAATAELYRKLVPLGRIGRPEEVADLALFLTGADSAYITGQPFVIDGGWLAGVSLF
>NZ_CP029196.1|WP_150160775.1|3221492_3222617_-|LLM-class-flavin-dependent-oxidoreductase
MEFGIFVQGYVGKRAETDPEAEHKALMEETEYVIQADRSGFKYAWASEHHFLEEYSHLSANDVYLGYLAHATDRIHLGSGIFNPLAPVNHPVKVAEKVAMLDHLSGGRFEFGSGRGAGSHEILGFMPGITDMNHTKELWEETIAEFPKMWLQEEYAGFQGKHWSLPPRKVLPKPYGKSHPAMWYAAGSPSSYAMAGRKGLGVLGFSVQKVSDMEWVVESYKTAIKEARAIGDFVNDNVMVTSTAICAETHDKAVEIAVGGGLNYLQSLLFRYHDTFPRPEGIPEWPELLPEYSAEIIELLIQEELMICGDPSEVLAQCKRWEQAGADQLSFGLPIGISYEDTMNSIKLIGEHVIPKIDTDPVHRTTRFRQSAGS
>NZ_CP029196.1|WP_150160774.1|3219569_3221309_-|amidohydrolase-family-protein
MLDHLITGATVVDGTGAPAFAADVGIRDGRIAVVAEPGTVREDARTTEDATGLVLTPGFVDPHTHYDAQLFWDPYATPSMNHGVTTVAGGNCGFTLAPLHPDRPEDADYTRRMMSKVEGMALKALEEGVDWSWSSFAEYLDALDGRIAVNAGFMVGHCALRRYVMGPDAVGGQPTPAQLAQMVVLLKEAMEAGAWGLSTTQSATHSDGDGAPVASRHATPAELVALSRAVGEHEGTQLEAILAGCLDQFSDDEIDLFVEMTAAAGRPLNWNVLTIDAAVPERVPRQLTASERARKSGGRIVALTMPILTPMNMSLGTFCALNLIPGWGEILALPVPERIAKLRDPDVRAEMLRRADSKEAGVFRRLAHFGRYVIGDTYSPENDGLTGRVVGDIAAERGQDPFQCLVEICANDELRTVLWPMPSDNDPASWALRRETWGHEDVMLGGSDAGAHLDRMCGAPYTTRFIGDCLRGRKLVPLERAVKMLTDDPARLFGLRERGRITEGFHADLVLFDPERIDAGPATLVHDLPGDSPRLDSRAVGIVSVRVNGVETVRDDEVTGAIPGKVLRSGRDTRTVSTR
>NZ_CP029196.1|WP_150160773.1|3218118_3219573_-|aldehyde-dehydrogenase-family-protein
MRTEKLFVGGEWVEPDGGHYEVIDPATEEVVGLAPEASRAQVYEAAAAAREAFASWSRTTPEERAAILDRAADLMARDADANTLLARAETGATTGTARGMQVAVGSSRFRRYARGALEPVEQALPPQINEAGPMGRAGVFGAVAVRRPVGVVTCITSYNNPWANPAGKIAPALAMGNTVLVKPAPQDPLSVYAMTRALEEAGVPPGVVNVVTGSSAEAGEAAVDSPDVDMVSFTGSTAVGQAIGEVCGRTLKRQLMELGGKGAALVFDDADLDSAVMGIGTTFSFYSGQICTAPTRVLAQRGIYERLIEKLTGYLAFMKVGDPAEKGTVVGPVISAVHRDRVEAYVELGRKEGARVVAGGERPDFAKGFYVAPTLLADCTNEMRVVREEIFGPVVVVVPFDDEEEGIALANDSDYGLLDYVWSGDVARAFRIAARLRAGGVGVNTIGRNMEAPFGGFKKSGVGRDVGSYALHAYSELQAVVWPG
>NZ_CP029196.1|WP_041662513.1|3216305_3217880_-|APC-family-permease
MTQVEARPQAGDTVRGVNAPGDTDSAHGVRTKGLGGNSVGLLGSAVIGISTVAPVYCLTSTLGSTAGEVGLQMPAIFLAGFLPMLLVAFAYRELNKVMPDCGTSFTWTVKAFGPRIGWMCGWGLVIATIIVLSNLAGVATSYFWLLAGEISGSESIAALDDNKAVHILTCLALIAAATAISYRGMTATKGVQYTLVGLQLVVLAVFVGMALTKAGSFETSVDFSWSWMNPFAVQSFAAFTAGLSLSIFMYWGWDACMATNEETTGSAKTPGRAALIAMVVLVGSYLATGIAAQMVVGSGEDGLGLANPETSDNVFAALAGPVMGPTLGILLFVAVLASAAASLQTTFIPVARTVLAMATYEALPKSFTKVHPVFKTPGKATIVAGVATGVFYTVMTLLSENVLVDTIYALGLMICFYYALTAFACVWYFRGELFRSGRDFAYKGLMPLLGGLMLTAVFGKTLYDMWDPAYGSGSAVFGVGSVFVIGVGLLLIGVVIMLVMQRRSPAFFRGEVLTKETPSLVVAD
>NZ_CP029196.1|WP_150160772.1|3216014_3216230_+|hypothetical-protein
MKRILTAAALTVFAAAGAAGATAGTAAADTGGMNLPSVVPLSGVLTPKAKPAGTPDLPPANAAVERLLPGR
>NZ_CP029196.1|WP_150160771.1|3215411_3215927_-|GNAT-family-N-acetyltransferase
MITWSMRPARAEDVEAVAELRAVVMRDDLVRLGVYDEHQVRQRLRNRFRAEHTWIVEVDGAFAGCAALVPNAEVGDQGHGPDHRDTEGFWLEHFYLAPETQGRGFGTAVLRELLDRADAAGLPVRLQSLRGSAAVRLYEREGFTVETETPLDLWMIRAPRTRTAAALSSPR
>NZ_CP029196.1|WP_150163611.1|3230013_3231582_-|AMP-binding-protein
MRGDLEWGTIPGLVRAAAERHGPREAVVDGRTRVTYTELGERVERAAAACLATGVRAGDRVAIWAPNTLDWIVAALGAVTAGAVLVPLNTRFKGTEAAFVLQRSRARLLFVTGTFLGTSYVASLRRAGVDLPDLEKVVVLGDTAPEEWTTWKEFLAEGDAVPAARVRARADAIDPTSPSDIIYTSGTTGRPKGAVISHAQSLRCYAIWCELAGLREGDRYLVVNPFFHTFGYKAGILACLMRGAVIVPQSVFTVDTVLANIAAERITVLPGPPTLHQSLLDHPARGAHSLATLRLVVTGAAVVPLRLVERLRTELGVGTVLTAYGLSEASGIVTMCRREDPAGTVATTSGRAIPGTEVRLSATGEVLVRGHHVMSGYFEDEEETAAAIDADGWLHTGDIGVLDEAGNLRITDRLKDMFIVGGFNAYPAEIEQLLGLHPDIADVAVIGVPDPRLGEVGKAFVVRRPGARATADDLIAWSRREMANYKVPRQIEFVPDLPRNASGKVVKGELRARTNSTSGTSD
>NZ_CP029196.1|WP_015034300.1|3231672_3232815_+|lipid-transfer-protein
MLKDATAIVGIGQTAFAKQLPETEKTLACRAILAALDDAGIAPSEVDGFASYTMEETDEVEVAKAIGAGDVTFFSKVGYGGGGSCATVGHLAAAIATGQASVGVAWRSRKRGSGPRPWKNTAVQLPTPGQWTRPFGLLRPADEIGMLARRYMHEYGATRDHLFNVALACRNRANQNPAAIMYERPLTREMYMTSRWISDPLCLFDNCLETDGALACVIVGAERARDCRQKPVYVHSAAQGLPSQHHGMVNYWNDDPLSGPAWTAARHLWKQADFGPQDVDVAQIYDAFTPLVPLSLEGYGFCGRGEGGAFTEGGALEIGGRLPLNTGGGGLSEAYVHGFNLINEGVKQLRGTSTAQVPDAATCLVTAGEGVPTSAVLLRS
>NZ_CP029196.1|WP_150160780.1|3232820_3233246_+|hypothetical-protein
MLTPVTDEDGAPFWEYAAQGELRVQSCADCGELRFPPRPCCPHCQSFASEWRLMSGRGRIWSYVFPHPPLLPDYAAQAPYNAVIVELAEAPRIRLVGNVVATPDAALDSVDPARLRIGAGVRVAFTEVDGTTVPRWLLERG
>NZ_CP029196.1|WP_150160781.1|3233242_3234013_+|enoyl-CoA-hydratase/isomerase-family-protein
MTVTVSRDKETGIAVVTLDRAAKHNAITLDMARRLSDVWREFRYADEVRAIVVTGAGGRAFCTGIDRSAEVPQPSSPYTIDDPLLTIGPKANDLWKPVVAAVEGMACGGAFYLLGEAEFLVAGEDASFFDPHTTYGMVSAFETIHMAQRMPYGEIARMALMGSAERLSARRAYDTGLVSELTPPGGALAAAMRAAAVIASHPTEAVQGTVRALWSAREAARAQALAHAPHLVALGNLPPDRQAELFGRRVDGHRLR
>NZ_CP029196.1|WP_150160782.1|3234047_3234608_-|hypothetical-protein
MVRTRLKLAATLTVVVLALTGFHTGHGSSGSGGGSGKSKSGKSKSRDSDDDSGGGCSNDEKSNDDYSGSGGSGTQTTAPTPTASRAVAEVVVVDCVKPAEKKRKGRPARKADTTATLEITSKSWDTETFRVTLEFKGSSGSAVDSAETLVTVEGGKTKRFEVGMKNPKVVGQVKNCWVYDVRVQQG
>NZ_CP029196.1|WP_150160783.1|3234735_3235377_+|hypothetical-protein
MIRNIAGSVLALAGATAAVWSPFRAWYDGRHGRDYAIDELFTGITDAKADLLGSMLAPFLFAALLTLLGVLLRSRLLVALAGLVVLGFTVLWMVRVGQAEGSLTVGGDGAGLGDGVANAIGGGVLLLLGALVMSGRSRPERRVDHGPRPTHPTLDGPPAEPHPGPHPDPAPHPQQQTPAPYAETQTYDVPAHDPDRDRDHDPGRDRENPPPRS
>NZ_CP029196.1|WP_150160784.1|3235404_3237885_-|PQQ-binding-like-beta-propeller-repeat-protein
MEQLTQHDPRRIGPFEVLGRLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTREVEAARAVSGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGPLPAQAVRWLAAGVAEALQSIHGAGLVHRDLKPSNVLVVEDGPRVIDFGIASGVSNTRLTMTNVAVGTPAYMSPEQARDSRSVTGASDVFSLGSMLVFAATGHAPFHGANPVETVFMLLREGPDLEGLPEELRPLIESCMQMDVTRRPTPADLQAQLAPHLFGPGSDDSGTASAWLPRSATEMIEIRRNGGRAAPGPTAPPMPPRPPRQPADRGADPRFPEPAPVGGGDRRPEPAPVGGGRHAGPSESSAGPVRLGGATVPIGPGPRVADTRAALAVGRSADAGPATGWIRPPGGGPHGADPGSYAGEHGSYAGEPGPPPGSRPVNVPPQGSDQGAPAEPGPWRPWRFRMSNDVWGTPVVDGDLLYVTSFEVHALDTGSGRRQFKTRDVAWSMAVASGRIHASDGPTLYALDATDGSERWRLRTDAWVYSLQVDRGTVVTGTRGGGVQGWEASNGAKLWEITGAQTDFETPEAGPAVHGDTVYVWRDARLQALDARTGVERWSYPIGDAASCAGVPVRVAPAEDGCVYVSAGTRVLSIDIAAGHVRWHFEAPAVFLSPPAFAPGPAVTGGGVYLSDHLGTVYAIDATTGQDRWRIATEPRQSTEPVLVADGNIHVGSGSALYTLDAVTGTPRWRFAAGGELVGSPVVADGRVHFGSADHVLYTLDATGGQLRWKLATGGEITGSPVARGGVVYACSKDRCVYALDAVKGTATGRGAAAR
>NZ_CP029196.1|WP_150160785.1|3238022_3238904_-|VOC-family-protein
MAARIEGTPCWVDAQLPDLEAGKRFYGELFGWTFDADRDEALLGGRRVAGLLPKRDGRMPTTWTLYLATQNAGTLATRIKAAGGQMVMEPYPVGPFGVLALAADPGGAVFGLRQSGDDDGFEVTNEPGAFCWMEVYTRRPDAVDTFYATVFGYLGRQADPEAEGRDAAFDYRVWSPPGSRPGDDSAFGGRAVITDDFPAVMPGHVLVYFAVQDCDRACETTVRLGGRVATPAFDTPHGRIAVLHDNQGARFAVLSEPASEPISRPASEPASRPASEPASEPASRPAPEPRGEG
>NZ_CP029196.1|WP_015034308.1|3239233_3239881_+|TetR/AcrR-family-transcriptional-regulator
MTGQVRTVDGRVAGRRGQATRQKLLDCLGEMLSSSPYRDVKVIDVARKAGTSPATFYQYFPDVEGAVLEIAEEMAKEGAGLTELVSGRSWVGKAGWQTSEELVEGFLDFWRKHDAILRVVDLGAAEGDKRFYKIRMKILNSVTNSLTDAVKELQTKGKVDKEVSPAAMAGSLVAMLAAVAGHQKGFTTWGVKQAELKPNLALLVHLGITGKKPTR
>NZ_CP029196.1|WP_015034309.1|3240018_3240489_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MPVGRTLMQKMSSTRTFARIGPHVVPAMDKAVHRLTRGKVLLSAQMLPGVVLTARGARSGLPRVTPLACMPEPDGRWLLVGSNFGRPGHPAWTANLLAHPDVEVNWKGEDIPVRAELLTGEERAEAWRAALAFWPPYATYQARIEREIRLFRLTRR

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Crispr_ID: NZ_CP029196_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_9

3345210-3345470

Orphan

Consensus_repeat	Method
CGGCGGNGTNGTCGGCTC	CRT

5 spacers

The CRISPR arrays of NZ_CP029196_9

>merge|NZ_CP029196|9|3345210-3345470|CRT
CGGCGGGGTCGTCGGGTCCGGGGGGCCCGGGTCCGTGGTGGTCGGCGGGGGTTCCTCGGTGGTCGGCGGCGGCGTCGTCGGCTCCGTGGTCGGCGGACTCGTCGGCGGCGTCGTGGGCTCGGTGGTCGGCGGGGGTTCCTCCGTCGTCGGCGGCGGCGTCGTCGGCTCCGTCGTCGGGGGACTCGTCGGCGGCGTGGTCGGCTCGGTGGTCGTCGGCGGCGGAGTGACCGGGTCGACGACCGGCGGCGGTGAGGTCTGCCC

>NZ_CP029196|9|3|3345210-3345470|CRT
CGGCGGGGTCGTCGGGTC	CGGGGGGCCCGGGTCCGTGGTGGTCGGCGGGGGTTCCTCGGTGGTCGG
CGGCGGCGTCGTCGGCTC	CGTGGTCGGCGGACTCGT
CGGCGGCGTCGTGGGCTC	GGTGGTCGGCGGGGGTTCCTCCGTCGTCGG
CGGCGGCGTCGTCGGCTC	CGTCGTCGGGGGACTCGT
CGGCGGCGTGGTCGGCTC	GGTGGTCGTCGGCGGCGGAGTGACCGGGTCGACGACCGG
CGGCGGTGAGGTCTGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_015034407.1\|3342287_3343124_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_CP029196.1\|WP_150160833.1\|3334660_3335398_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|272861
NZ_CP029196.1\|WP_150160837.1\|3341679_3342291_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NZ_CP029196.1\|WP_150160843.1\|3357005_3358586_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP029196.1\|WP_150160836.1\|3337393_3339622_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NZ_CP029196.1\|WP_015034416.1\|3353398_3353971_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP029196.1\|WP_015034411.1\|3347142_3348537_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NZ_CP029196.1\|WP_015034418.1\|3354833_3355535_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP029196.1\|WP_150160838.1\|3344302_3345130_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_030324225.1\|3349309_3350434_+\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|237395
NZ_CP029196.1\|WP_015034415.1\|3352271_3353207_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115
NZ_CP029196.1\|WP_150160841.1\|3351566_3352238_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239489
NZ_CP029196.1\|WP_150160834.1\|3336349_3336865_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150160840.1\|3350495_3351338_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369035
NZ_CP029196.1\|WP_015034408.1\|3343328_3344261_-\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NZ_CP029196.1\|WP_150160835.1\|3336900_3337236_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|227324
NZ_CP029196.1\|WP_150163615.1\|3335394_3336165_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP029196.1\|WP_015034419.1\|3355579_3356896_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP029196.1\|WP_015034405.1\|3339700_3341554_-\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|237104
NZ_CP029196.1\|WP_150160842.1\|3353958_3354723_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015034407.1\|3342287_3343124_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	2.04936e-27
NZ_CP029196.1\|WP_150160833.1\|3334660_3335398_-\|ABC-transporter-permease-subunit	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	2.66229e-26
NZ_CP029196.1\|WP_150160837.1\|3341679_3342291_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	2.38818e-33
NZ_CP029196.1\|WP_150160843.1\|3357005_3358586_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.13537e-69
NZ_CP029196.1\|WP_150160836.1\|3337393_3339622_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.63813e-83
NZ_CP029196.1\|WP_015034416.1\|3353398_3353971_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	3.32574e-56
NZ_CP029196.1\|WP_015034411.1\|3347142_3348537_+\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NZ_CP029196.1\|WP_015034418.1\|3354833_3355535_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.94815e-82
NZ_CP029196.1\|WP_015034419.1\|3355579_3356896_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.59268e-32
NZ_CP029196.1\|WP_030324225.1\|3349309_3350434_+\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|237395	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional.	0
NZ_CP029196.1\|WP_015034415.1\|3352271_3353207_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.08586e-82
NZ_CP029196.1\|WP_150160841.1\|3351566_3352238_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239489	cd03395, PAP2_like_4, PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	2.69427e-17
NZ_CP029196.1\|WP_150160840.1\|3350495_3351338_-\|hypothetical-protein	gnl\|CDD\|369035	pfam06682, SARAF, SOCE-associated regulatory factor of calcium homoeostasis. SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.	0.0054998
NZ_CP029196.1\|WP_015034408.1\|3343328_3344261_-\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	7.48955e-80
NZ_CP029196.1\|WP_150160835.1\|3336900_3337236_-\|SH3-domain-containing-protein	gnl\|CDD\|227324	COG4991, COG4991, Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown].	1.13881e-10
NZ_CP029196.1\|WP_150163615.1\|3335394_3336165_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.0915e-78
NZ_CP029196.1\|WP_015034405.1\|3339700_3341554_-\|dihydroxy-acid-dehydratase	gnl\|CDD\|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0

>NZ_CP029196.1|WP_150160838.1|3344302_3345130_+|hypothetical-protein
MPKTKKAKPGKDGPVKSAKKRGKNVEPDEKGLDFARAWVEFPDPADDEQVFRCDLTWLTSRWTCIFGSGCQGIQAGRADDGCCTLGAHFSDEDDEKRVASHVARLTPELWQFHDVGTASGWTQTDEDGDRQTRRWEGSCIFQNRPGFAGGAGCSLHILALREGKEPLETKPDVCWQLPVRRTYDWIERPDDTKVLQVSIGEYDRRGWGPGGHDLHWWCTSATSAHGAGEPVYVTYRPELTEMMGTEAYEVLAGLCAARLASQLPLVAPHPADPKG
>NZ_CP029196.1|WP_015034408.1|3343328_3344261_-|Ppx/GppA-family-phosphatase
MRLGVLDVGSNTAHFLVVDAHPGARPLPAHSHKAELRLAELLDERGAIAPHGVERLIATVRDALLAAEDKGCEEVLPFATSAVREASNADAVLARVKDETGVDLQVLTGEEEARLTFLAARRWFGWSAGKLLLLDIGGGSLEVAYGIDEDPDTAVSLPLGAGRLTAGWLPGDPADSADVKALRRHVRAQIARTVGEFSRSGRPDHVVATSKTFKQLARIAGAPGSGEGLYVQRILTRRALEEWVPRLAGMTVPERAALPGVSEGRAGQLLAGAMVAEGAMDLLGVEELEICPWALREGVILRRLDHLPTK
>NZ_CP029196.1|WP_015034407.1|3342287_3343124_-|sugar-phosphate-isomerase/epimerase
MAEPVVRIPDAKVALSTASVYPESTATAFEIAARLGYDGVEVMVWTDPVSQDIEALRRLSDYHQVPILAVHAPCLLITQRVWSTDPWVKLQRAQAAAERLGASTVVVHPPFRWQRQYAKDFVTGIWRMADETDVRFAVENMYPWRYKDREMLAYAPEWDVTKDDYRHFTVDLSHTATARTDALAMIDRMGDRLGHVHLADGKGSAKDEHLVPGRGTQPCAELLERLARTGFDGHVVIEVNTRRAMSAAEREADLAEALAFTRLHLASAAGRPSRVPRP
>NZ_CP029196.1|WP_150160837.1|3341679_3342291_-|TetR-family-transcriptional-regulator
MTGPAPRRRGRPSRTEEETGPGARERILEAARAQFAERGYDKTSVRGIGKAAGVDPALVHHYFGTKDEVFAAAIEVSFEPAAVVPAIVGGPRDTIGERLARFFIGVWENPASRAPLLAIVRSALTHEAAAKVLRTFVLRRLLERIAAELDVPDPKFRAELAASHMIGIAILRYVIQVEPMASADPERIVEMVAPTLQRYLTEA
>NZ_CP029196.1|WP_015034405.1|3339700_3341554_-|dihydroxy-acid-dehydratase
MPELRSRTVTHGRNMAGARALMRASGVPGADIGRKPIIAVANSFTEFVPGHTHLQPVGRIVSEAITAAGAIPREFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVEAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMESGRATLVDGTVRTLDLVDAISDAVNPNISDEDIARIEENACPTCGSCSGMFTANSMNCLTEAIGLSLPGNGSLLATHTARKGLYEAAARTVVDITRRYYDEDDDSVLPRSIATRAAFENAMALDIAMGGSTNTILHLLAAAQEAELDYGLSDMDEVSRRVPCLAKVAPNVAKDRTYYMEDVHRAGGIPAILGELYRAGLLNEDVHAVHSRSIKEWLGTWDVRGGSPSEESVELWHAAPGCVRSATAFSQSERWAALDVDAAGGCIRDAAHAYSKDGGLAVLRGNLAVDGCVVKTAGVDESIWTFEGPAVVCESQDEAVEKILNKQITDGDVVVIRYEGPRGGPGMQEMLYPTSFLKGRGLGKTCALVTDGRFSGGTSGLSIGHASPEAASGGTIALVEDGDRIRIDIPSRSIELLVDEATLAARREALGGVYQPKNRQRKVSAALRAYAAMATSADKGAVRDVTKLG
>NZ_CP029196.1|WP_150160836.1|3337393_3339622_+|PQQ-binding-like-beta-propeller-repeat-protein
MPPLRGTGADREAEGPEYAGDYRLQACLGAGGMGVVHLAASASGLRLAVKVVHARYAEDPEFRARFRQEVAAARRVSGAFTAPVVDADPDAVRPWMATLYVPGPTLADQVKRNGPLAPAELRRLTAGLAEALRDIHRAGVVHRDLKPSNVLLTDTGPKVIDFGISRPVDSDLHTETGKLIGSPPFMAPEQFQRPREVGPAADVFALGSVLVHAATGHGPFDSDSPYIVAYQVVHDEPDLTGVPAELAPLVARCLAKDPAERPSPAQIMAALLPPSYAAEAFIPAQRRRPSLPDGEDGAYGETGSRGGRGEPGPSPAWDADTPVRATAPVPPRRARPLRGGRLRPRLTIAVAAAVALAGAGIYAAMSPPARGGTEPPARPGEVATAFAGWETTLQKHGPTAAPACAHGEGALYCAARGVGLARLDPVTGKVLWSLDAPVKAESPLAPFVLTGGARGTGGLVGAAAPTGPLRAYTAERGAPAWSTSSKLPESFRPAGSAVVLTDGQGGVRAVDGQSGKELWRHGLSGFDVPRPGPYDTVSGLLAVSETSADGTHTRVGEFRPRTGEVVRQRNLRGALEPLGRTSDGALVLGSLYQASLYDALVLLDPAGGSVRRLPLPHRIDVRGVAVHGSVAHVLDADGHLTAFDTAAPKGRVLWELETGAGNVSTPVGGPGDRLYFSVQDGRLLAVDTVRGALVGQTRPRLLNGRLDYAPLVPPPLVAGDRVFGTAPDGSVFAVDARDPASW
>NZ_CP029196.1|WP_150160835.1|3336900_3337236_-|SH3-domain-containing-protein
MSTDENTTTATAATAAATAGETVAAMASTATRYAVAPGYRVNVRSGPSTQYPVVRSLPLGATVAISCQKYGEWITGPYGTTKIWDNIAPGEYVSDAYVRTGSDGLVAPRCA
>NZ_CP029196.1|WP_150160834.1|3336349_3336865_-|hypothetical-protein
MSDEEQTPSPTGGTPAGPQPEEIRFFGTTWVDHSGNYTLRRVGLAAGSLAAAVAACFVLRFAYEGLQIAAVGGIVNMLVVIMFAVCSAIAFRKTWEGYLRRPADPAREESLRSLKAIGFIGALLAYCARCFVEAPGEKLRRAEYETARAQFEKRRGARTGNPAARKKPKRK
>NZ_CP029196.1|WP_150163615.1|3335394_3336165_-|ATP-binding-cassette-domain-containing-protein
MTARDLTVVRGDRTVLHGLDFTVTAGRITGLLGPSGCGKSTLMRAIVGTQAKVDGTLHVLGRPAGDPTLRSRIGYVTQAPSVYDDLTVRQNLDYFAAVLLPGRAHREERRTAVDRAIDDVDLASHTDHLAGRLSGGQRSRVSLAVALLGTPELLVLDEPTVGLDPVLRRDLWNLFHQIAADRGTTLLVSSHVMDEAERCHRLLLMREGEILADDTPEALRRRNDTATVEEAFLHLVDAAAARTAQAARAAHEEPRP
>NZ_CP029196.1|WP_150160833.1|3334660_3335398_-|ABC-transporter-permease-subunit
MSPARTLATAARVLRQLRHDPRSIALMLLVPCVMLFLLRYVFDGSPGTFDNIGASLLGIFPLITMFLVTSIATLRERTSGTLERLLAMPLGKSDLIAGYALAFGLLAVVQSTLATGLAVWFLGLDVIGSPWLLLLVALLDALLGTALGLFVSAFAASEFQAVQFMPAVIFPQLLLCGLFTPRDHMAPALEAISDVLPMSYAVDGMNQVLRHPDITGDFVRDALVVAGCALLVLGLGAATLRRRTA
>NZ_CP029196.1|WP_015034411.1|3347142_3348537_+|DNA-repair-protein-RadA
MAARTKSTKDRPSYRCTECGWQTAKWLGRCPECQAWGTVEEYGAPAVRTTAAGRVSTAALPIGQVDGRQATARSTGVDELDRVLGGGLVPGAVVLLAGEPGVGKSTLLLDVAAKAASDEHRTLYVTGEESASQVRLRADRINALSDHLYLAAETDLSAVLGHLDAVKPSLLIMDSVQTVASPEIDGAPGGMAQVREVAGALIRASKERGMSTLLVGHVTKDGAIAGPRLLEHLVDVVLSFEGDRHARLRLVRGVKNRYGATDEVGCFELHDEGITGLADPSGLFLTRRDVAVPGTCLTVTLEGRRPLVAEVQSLTVDSQIPSPRRTVSGLETSRVSMMLAVLEQRGRISALGKRDIYSATVGGVKLTEPAADLAIALALASAASDTPLPKNLVAIGEVGLAGEVRRVTGVQRRLAEAHRLGFTHALVPSDPGKVPAGMKVTEVADMGDALRVLPRGRRAKTAEA
>NZ_CP029196.1|WP_030324225.1|3349309_3350434_+|DNA-integrity-scanning-protein-DisA
MAAKDGAAAPGKSGAGSGNEALMRAALSAVAPGTALRDGLERILRGNTGGLIVLGLDKTVDSMCTGGFVLDVEFAATRLRELCKLDGALVLDKDITKIHRAGVQLVPDASIPTEETGTRHRTADRVSKQCNFPVVSVSQSMRLIALYVDGERRVLEESAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVAQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELIAGVEPERELVIRDYVPEPTAKRSRTVAEALTELDALTHTELLELPVVARALGYSGSPETLDSAVSPRGYRLLAKVPRLPGAIIERLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV
>NZ_CP029196.1|WP_150160840.1|3350495_3351338_-|hypothetical-protein
MGSLRNPVGPLPSTIYWRRRAVAACLVALLALLTVWAVTSGGGGGKKTNDGANGSSPTPPSITPGPSGTGPAISQQPGGRDESDDSGDSTGGDAGSGGPGTDPGTGTGTDAGTAAGTDGGKNGDTDGAGGDGGAGTGAGQRVPANSPLPNCPAGSLQLTLRSAKVSYEPGEKPRFHLVAKNPSTTDCKADFGPRTAILTISDGKNGEFWSSADCPRPGDPILLKVPAGATVTHTVEWDRGRSAPQCATTPAGQAGPGTYLVEAKVPGAKVLPASFTLAKD
>NZ_CP029196.1|WP_150160841.1|3351566_3352238_+|phosphatase-PAP2-family-protein
MNTLLDLSDRLYLDVADFAHSTPHWFQWLAEVWTEAGLLLFGVLFLAGWWRAREGASRMMALALLAPLATAFGYVVSESLKSLIDEERPCRAVIGAPASLVACPPHGDWSFPSNHSAIAGAAAIALALSWRGIGRLTVPMALLMAFSRVFVGVHYPHDVTVGLLLGGLVAFLVMKAAVRPVGALVETARSSRSAAVVWCAGRGPRAHAPAYAQEPQRARHGAY
>NZ_CP029196.1|WP_015034415.1|3352271_3353207_+|A/G-specific-adenine-glycosylase
MTSIDASPMPEAPSAPALPTPPAELHGPVLAWFDRHARDLPWRRPEAGAWGVMVSEFMLQQTPVVRVLPVYEQWLARWPRPADLAAEASGEAVRAWGRLGYPRRALRLHAAAVAITERHGGDVPSDHGQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARAATGVQYPPNATTAAERRLARALLPQDESTASRWAAASMELGALVCTAKNEDCSRCPIAGHCAWRLAGKPAHDGPPRRGQTYAGTDRQVRGRLLAVLRESTDPVAQAVLDTVWDEPVQRARALDGLVADGLVEPLDGGYFRLPMA
>NZ_CP029196.1|WP_015034416.1|3353398_3353971_+|SigE-family-RNA-polymerase-sigma-factor
MRHGEVLDFEEYVRTRQEALLRSARRLVADPVDAQDLLQTALARTFGRWDGIADKSLADAYLRRVMINTRTEWWRSRKLDEVPTEQLPDASVDDPTEQHADRALLMDVLKVLAPKQRSVVVLRHWEQMSTEETAAALGMSTGTVKSTLHRALARLRQELESRDLDARALGRTGERTTVRGDERGRERCAA
>NZ_CP029196.1|WP_150160842.1|3353958_3354723_+|hypothetical-protein
MRGLDGEADGSRHDGDSGIDSGDGAGGGDRYGTGRRRRRGTAKAASITAAAGLVAVGLSMAACSTGGTGSRDEGAAATKEVAAAAPTPSASPGGGQRSAERVDPIALLKGDPKIGERLKTDLKPCVADAYPVDTSYGNLTNAAAPDVVVNVMTCGDAVGIGTYVYRKQSDRYENVFMAEDAAVYGTIDRGELVVTKQVYAKGDPVAYPSGEDVITYRWSGNGFTQHDWVHNDYSRAVDGGSAVTEPAPSEPPVR
>NZ_CP029196.1|WP_015034418.1|3354833_3355535_+|response-regulator-transcription-factor
MAETHVLFVEDDDVIREATQLALERDGFRVTAMPDGLSGLDAFRAQRPDIALLDVMLPGMDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGSVLMARIRAVLRRFGHAGGPGAGEHGEETPDGGLLAFGDLEVDTEGMEVRKAGAPVALTPTEMRLLLEFSSAPGTVLSRDKLLERVWDYGWGGDTRVVDVHVQRLRAKIGQDRIETVRGFGYKLKS
>NZ_CP029196.1|WP_015034419.1|3355579_3356896_+|HAMP-domain-containing-histidine-kinase
MKLLPLRTGVRWKIAVAIAAVGALIAVTLSVVVHNAARISMLDNAREVQMERLLFAQRMYETSKPKEPRFGTKINDPSLPPQLDQLMRDKRRGTYVQEHRHGGPPDVWAAVPLANGDVLSLHIPFADRSATIMNDLDRALVIGSVSVVFGGCALGVLIGGQLSRRLRKAAVAAGRVAQGNTDVRVREAVGGVVRDETDDLAWAVDALTDALNERIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVRDRAQAMRTLVEDVLEVARLDSASERAELQEIALGEFVERRVRALDPEVVVRVVHDSWVNTDPRRLERVLGNLLANAAKHGRPPVEVTVEGRVVRVRDHGPGFPEALLKEGPSRFRTGTSDRAGQGHGLGLTIAAGQARVLGARLTFRNVASEAAPNGVGGAIAVLWLPDHAPTNTGSFPILRPAD
>NZ_CP029196.1|WP_150160843.1|3357005_3358586_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MTTQATANPVQGETEPQPRSVRVVLLALMIAMLLAMLDNMIIGTAMPTIVGELGGLEHLSWVVTAYTLATAASTPLWGKVGDMFGRKGVFLTSIVIFLIGSALSGMAQDMGQLIGFRTIQGLGAGGLMVGVMAIIGDLIPPRERGKYQGMMAGVMALAMIGGPLVGGTITDHWGWRWSFYINLPLGAVALAMITTVLHLPKRQRDKGTRIDFLGAALLTVGITAIVLVTTWGGTEYAWGSATIVGLAVGGALALAAFLWAETRAADPIMPLHIFRSRNFTLMSLIGFITGFVMFGAVLYLPIFQQSVQGASATNSGLLLLPMLLAMMVVSLVVGRFTTSTGKYKIFPIIGGALMMTGLFLLSTMDTGTSRLVSGIWMAVLGAGMGFLMQITMLVAQNSVEMKDMGVASSSTTLFRTLGSSFGVAIMGALFTSRVQDEMASRGGGGLTERTAQLDAASLAKLPEALREAYQHAVATGTHGAFLVASAVSVLGLVLAFFVKEVALRGAGPAPAPKTESGESAKVAETV

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Crispr_ID: NZ_CP029196_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_10

3481591-3481694

Orphan

Consensus_repeat	Method
GCCGCACCCCGATCACCCGGGAGCCC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP029196_10

>merge|NZ_CP029196|10|3481591-3481694|CRISPRCasFinder
GCCGCACCCCGATCACCCGGGAGCCCCGCCCGGCGCCGAGCCGCGCCCCGATCGCCCGGGGCCCCCGCCCGGCGCCCAGCCGCACCCCGATCACCCGAGAGCCC

>NZ_CP029196|10|6|3481591-3481694|CRISPRCasFinder
GCCGCACCCCGATCACCCGGGAGCCC	CGCCCGGCGCCGAGCCGCGCCCCGATCGCCCGGGGCCCCCGCCCGGCGCCCA
GCCGCACCCCGATCACCCGAGAGCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_041662548.1\|3474583_3475234_-\|small-secreted-protein	unknown	unknown	gnl\|CDD\|341072
NZ_CP029196.1\|WP_150160914.1\|3471776_3472781_-\|helix-turn-helix-domain-containing-protein	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
NZ_CP029196.1\|WP_150160916.1\|3475457_3477767_-\|sodium-translocating-pyrophosphatase	unknown	unknown	gnl\|CDD\|234827
NZ_CP029196.1\|WP_150160920.1\|3482506_3483289_-\|type-II-secretion-protein-F	unknown	unknown	gnl\|CDD\|366122
NZ_CP029196.1\|WP_150160922.1\|3484250_3485423_-\|TadA-family-conjugal-transfer-associated-ATPase	unknown	unknown	gnl\|CDD\|200328
NZ_CP029196.1\|WP_150163623.1\|3485419_3486508_-\|septum-formation-initiator	unknown	unknown	gnl\|CDD\|274798
NZ_CP029196.1\|WP_015034520.1\|3478412_3478766_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP029196.1\|WP_150160917.1\|3478846_3481312_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|274800
NZ_CP029196.1\|WP_150160925.1\|3490162_3491470_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200598
NZ_CP029196.1\|WP_041662552.1\|3488277_3489096_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|376885
NZ_CP029196.1\|WP_150160921.1\|3483285_3484251_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227300
NZ_CP029196.1\|WP_015034519.1\|3477938_3478397_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP029196.1\|WP_150160918.1\|3481265_3481586_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274799
NZ_CP029196.1\|WP_150160913.1\|3470585_3471644_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP029196.1\|WP_150163622.1\|3482141_3482372_-\|DUF4244-domain-containing-protein	unknown	unknown	gnl\|CDD\|379429
NZ_CP029196.1\|WP_150160923.1\|3487070_3487937_+\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|273654
NZ_CP029196.1\|WP_150160924.1\|3489198_3490185_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|349754
NZ_CP029196.1\|WP_150160912.1\|3469815_3470589_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223912
NZ_CP029196.1\|WP_150160915.1\|3472777_3474328_-\|methyltransferase	unknown	unknown	gnl\|CDD\|237872
NZ_CP029196.1\|WP_150160919.1\|3481798_3482131_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_041662548.1\|3474583_3475234_-\|small-secreted-protein	gnl\|CDD\|341072	cd09609, M3B_PepF, Peptidase family M3B, oligopeptidase F (PepF). Peptidase family M3B oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and is similar to oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity. The PepF gene is duplicated in L. lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.	0.000410615
NZ_CP029196.1\|WP_150160914.1\|3471776_3472781_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	7.52056e-14
NZ_CP029196.1\|WP_150160916.1\|3475457_3477767_-\|sodium-translocating-pyrophosphatase	gnl\|CDD\|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NZ_CP029196.1\|WP_150160920.1\|3482506_3483289_-\|type-II-secretion-protein-F	gnl\|CDD\|366122	pfam00482, T2SSF, Type II secretion system (T2SS), protein F. The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).	5.33161e-11
NZ_CP029196.1\|WP_150160922.1\|3484250_3485423_-\|TadA-family-conjugal-transfer-associated-ATPase	gnl\|CDD\|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	2.65921e-166
NZ_CP029196.1\|WP_150163623.1\|3485419_3486508_-\|septum-formation-initiator	gnl\|CDD\|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	5.33391e-73
NZ_CP029196.1\|WP_015034520.1\|3478412_3478766_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	8.65721e-33
NZ_CP029196.1\|WP_150160917.1\|3478846_3481312_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|274800	TIGR03817, DECH_helic, helicase/secretion neighborhood putative DEAH-box helicase. A conserved gene neighborhood widely spread in the Actinobacteria contains this uncharacterized DEAH-box family helicase encoded convergently towards an operon of genes for protein homologous to type II secretion and pilus formation proteins. The context suggests that this helicase may play a role in conjugal transfer of DNA.	0
NZ_CP029196.1\|WP_150160925.1\|3490162_3491470_-\|hypothetical-protein	gnl\|CDD\|200598	cd10976, CE4_CDA_like_3, Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins. The family includes many uncharacterized bacterial hypothetical proteins that show high sequence similarity to insect chitin deacetylase-like proteins. Chitin deacetylases (CDAs, EC 3.5.1.41) are secreted metalloproteins belonging to a family of extracellular chitin-modifying enzymes that catalyze the N-deacetylation of chitin, a beta-1,4-linked N-acetylglucosamine polymer, to form chitosan, a polymer of beta-(1,4)-linked d-glucosamine residues.	1.69009e-132
NZ_CP029196.1\|WP_041662552.1\|3488277_3489096_-\|Fic-family-protein	gnl\|CDD\|376885	pfam02661, Fic, Fic/DOC family. This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.	0.000343193
NZ_CP029196.1\|WP_150160921.1\|3483285_3484251_-\|hypothetical-protein	gnl\|CDD\|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	7.8651e-22
NZ_CP029196.1\|WP_015034519.1\|3477938_3478397_-\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	7.40766e-29
NZ_CP029196.1\|WP_150160918.1\|3481265_3481586_-\|hypothetical-protein	gnl\|CDD\|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	1.94317e-08
NZ_CP029196.1\|WP_150160913.1\|3470585_3471644_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.67159e-102
NZ_CP029196.1\|WP_150163622.1\|3482141_3482372_-\|DUF4244-domain-containing-protein	gnl\|CDD\|379429	pfam14029, DUF4244, Protein of unknown function (DUF4244). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	9.04472e-18
NZ_CP029196.1\|WP_150160923.1\|3487070_3487937_+\|HAD-IB-family-hydrolase	gnl\|CDD\|273654	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490. This hypothetical equivalog is a member of the IB subfamily (TIGR01488) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The sequences modelled here are all bacterial. The IB subfamily includes the enzyme phosphoserine phosphatase (TIGR00338). Due to this relationship, several of these sequences have been annotated as "phosphoserine phosphatase related proteins," or "Phosphoserine phosphatase-family enzymes." There is presently no evidence that any of the enzymes in this model possess PSPase activity. OMNI\|NTL01ML1250 is annotated as a "possible transferase," however this is due to the C-terminal domain found on this sequence which is homologous to a group of glycerol-phosphate acyltransferases (between trusted and noise to TIGR00530). A subset of these sequences including OMNI\|CC1962, the Caulobacter crescentus CicA protein cluster together and may represent a separate equivalog. [Unknown function, Enzymes of unknown specificity].	8.74407e-65
NZ_CP029196.1\|WP_150160924.1\|3489198_3490185_+\|ATP-binding-protein	gnl\|CDD\|349754	cd02034, CooC1, accessory protein CooC1. The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.	1.96791e-30
NZ_CP029196.1\|WP_150160915.1\|3472777_3474328_-\|methyltransferase	gnl\|CDD\|237872	PRK14968, PRK14968, putative methyltransferase; Provisional.	2.61187e-18
NZ_CP029196.1\|WP_150160912.1\|3469815_3470589_-\|ABC-transporter-permease	gnl\|CDD\|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	2.0748e-12

>NZ_CP029196.1|WP_150160918.1|3481265_3481586_-|hypothetical-protein
MWVAFAACALCVVFAAVLALGQAVAARHRAGGAADLAALAAADRALWGEVEACAAAARVAGAQGAELVGCVVRGDLAEVTARVARGPYRPEVRSRAGPPGPLGGSP
>NZ_CP029196.1|WP_150160917.1|3478846_3481312_+|DEAD/DEAH-box-helicase
MAFNHLPAAMHDALEALSVMAVTHSVPMATNQRPRRPAGDTGSRPSPGMVLDRLSSGESRAARITHTEHMPAREGRHAVWPHRIRAEVIAAIEAAGIEHPWAHQAEAAEHALDGESVVIATGTASGKSLAYLAPVLTTLLDGAEAPNGRGTTALYLSPTKALAADQRRAVRELAAPLGNRIRPAVYDGDTPVEEREWVRQYANYVLTNPDMLHRGILPSHPRWASFLRSLRYVVIDECHTYRGVFGSHVAQVLRRLRRICARYGSEPVFLLASATSAEPALAAGRLTGLPVTEVSDDASPRGELVFALWEPPLTELHGERGAPVRRTATAETADLLTDLTRQGVRSVAFVRSRRGAELISVIAQERLAETDRSLARRVAAYRGGYLPEERRALERALHSGELLGLAATTALELGVDVSGLDAVVIAGYPGTRASLWQQAGRAGRSGEGALAILVARDDPLDTFLVHHPEAIFDQPVESTVLDPDNPYVLAPHLCAAAAELALTEPDLALFGPAVPELLPQLEGAGLLRRRSTGWYWTRRERAADLTDIRGGGGSPVRIVESGTGRLLGTVDEAASHTAVHEGAVHLHQGRTYLVRELDLKDSVALVEEAAPPYSTTARDTTSIAVLDTETEIPWGAGRLCFGSVEVTNQVVSFLRRRLITGEVLGETKLDLPPRTLRTRAVWWTVTEDQLDAARITPEILGGALHAAEHASIGMLPLFATCDRWDIGGVSVPLHPDTLLPTVFVYDGHPGGAGFAERAFHTARAWLTATREAIASCECEAGCPSCIQSPKCGNGNDPLHKRGAVRLLTEILRAAPEAPPAT
>NZ_CP029196.1|WP_015034520.1|3478412_3478766_-|STAS-domain-containing-protein
MDLSLSTRNVSGAGGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSYHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTSVDEAVNAVD
>NZ_CP029196.1|WP_015034519.1|3477938_3478397_-|ATP-binding-protein
MATVELRFSAQPEHVRTARLVAAAVARRAGVDEAVLDEVRLAVGEACSRAVGLHRSNDVMTPIRVVLTEEEKTFSIEVGDEVPGAGVAAADAVGVPGARAAAPAEDFDDADGEDEMGLAVIRGLVDDVEVSAGEDGGTIRMSWPVSSADVLS
>NZ_CP029196.1|WP_150160916.1|3475457_3477767_-|sodium-translocating-pyrophosphatase
MYPTSLAAAVLTSGNRTIVYVVGAVALAALMVARLLVRQVLKSGEGTERMREIAAAVQEGANAYLARQLRTLAVFAVVVFFLLMLLPADNWSQRAGRSLFFLVGALFSAVTGYIGMRLAVRANVRVAAAAREATPAAGEPERSLTEVAHRAMRIAFRTGGVVGMCTVGLGLLGAACVVLVYAADAPKVLEGFGLGAALIAMFMRVGGGIFTKAADVGADLVGKVEQGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGKAAFGDHGLAFPLIVPAIGVITAVIGIFAVSPRRGDRGGMSAINRGFLVSAVISLAGVAVAAFVYLPSSYAELEGVTEPGIRDHAGDPRVLALVAVALGIVLAALIQQLTGYFTETSRRPVRDIGKSSLTGPATVVLAGVALGMESAVYTALLIGLTVYGAFLLGGASIMLALFAVALAGTGLLTTVGVIVAMDTFGPVADNAQGIAEMSGDVRGAGGQVLTDLDAVGNTTKAITKGIAIATAVLAASALFGSYRDAIATSVAEVGAKADELTLSMDISQPNNLFGLILGAAVVFLFSGLAINAVSRSAGSVVHEVRRQFREHPGIMNHTEKPEYGRVVDICTKDALRELATPGLLAVMAPIAVGFALGVGALGSYLAGAIGTGALMAVFLANSGGAWDNAKKLVEDGNHGGKGSEAHEATVIGDTVGDPFKDTAGPAINPLLKVMNLVALLIAPAVVRFSYGGDASVGLRAGVAAFALLVVLAAVRVSKKRPVTVS
>NZ_CP029196.1|WP_041662548.1|3474583_3475234_-|small-secreted-protein
MNKKLAAALSGGAVLVLALSGCSDDEGNKVDDWAKTFCDQAKPQIQKRADAHQIIISTAADSKPAEIQAADSKAFQDIADADRALAKAVESAGAPPVENGEKVQQDAIKELNATAVAYEGLKKQVDALDPTNQQKFADGLQGVADGLTKIEKMDQNALSKLEEGELGQAMAKQPGCQKPTASASPKAGSTASGSPGTGADASAKPSTKATPTKTEE
>NZ_CP029196.1|WP_150160915.1|3472777_3474328_-|methyltransferase
MSTTSLPPKLPVPAHAARLREALLAADFTADGLLDLLGAPAYAALARSETVPALRATRGDSPLATLVRLFLLQESVGHERAAAALPLDEALADGWVVGEDGSVSATVDVRPYGGPDGEDWFIVSDLGCAVGGAGGIGKKDEGVVLGVGGASTTLAGITVRTPVSSALDLGTGSGIQALHAAQHATLVTATDLNPRALDFTRLTLALSGAREAELLTGSLFEPVDGDTYDLIVSNPPFVISPGARLTYRDGGMGGDDLCRTLVQQAGERLNDGGYAQFLANWRHVEGEEWQDRLRSWVPAGCDAWIVQREVQDITQYVELWLRDSGDHRGDPEAYREAYGRWLDEFEAGKTRAVGFGWITLRRNDAVASGAVEPSVVVEEWPHPVEQPLGPTVRAHFERQDYLRRRDDAALLADRFTLAPEVVQEQVGLPGAEDPEHVVLRQNRGMRRATRVDHVGAGFAGVCDGTLSAGRILDAIGQLMGEDPVVLRDRTPQAIRLLVEEGFLLPVAEDAPEGGGA
>NZ_CP029196.1|WP_150160914.1|3471776_3472781_-|helix-turn-helix-domain-containing-protein
MIRIELDEASLGATRIAISPLRDAFCSMHLALPHRQPSWPYQEWVGQAREVWREDDRLRPLWDLFADGRYDVSDFLLPRPFGTVHVHEELTALRSTDPDFVRAQVAVCYPGMAEAPFVQPYLRDPQAACAALADAYAAYWEGAIEPYWPTMRRLVEDEVLVRARTFATEGVDALFAGLESRGRWQPPVLELTKHVEAEYAPGERRLVLVPLVFAEGCRLYSTDDPEVFALSFQARGAGALREPPEPTAEDRLGLMLGRGRAAVLRELGGPLTTAGLADRLGLAPSTVSEHLSVLAEAGVVTRHRVGRSVYYQLTDTGRSLLALLAGEDVLRAVA
>NZ_CP029196.1|WP_150160913.1|3470585_3471644_-|ATP-binding-cassette-domain-containing-protein
MLAIEADALRRTYTSRTGWPKSRRTESEAVRGVTFDVAPGELFGLLGPNGAGKTTTIKMLNTLLLPTSGTARVFGHDVARDPVAVRRRIGYVFGGDRGLYDRLSALDNLRYFAELYGVPARAQKRRITELLDLVGLLGREKEKVEGYSRGMRQRLHIARGLLHRPDVLFLDEPSIGVDPVAARDLRRTVADLADAGTTVLLTTHYMAEADELCDRIAVIAGGRIRALGTPDSLKSLVRERDVLEIEAYGVDEERLDRLRRVPGVRGVAAEDRGALQTVTVQTGRGAAELHGPVLAALDGVRLGRVTSREPSLEDAYIAIVEGTAAATGAASAGTVGAGAGAVEGTASQGAAV
>NZ_CP029196.1|WP_150160912.1|3469815_3470589_-|ABC-transporter-permease
MRRLPRLILVGVRTHVSYMSRSPIEITFAVLVPLVYATLAVYLFRAAGDPDRLLTASVGAGLMGIWGSVLFGSGGAVQNQRWLGTLETLVVAPTPLALVLLPITLATAVIGTYAMGATLLWGVLLFDVPLDFAHPVLFLLAVPVCVLALGMTGLLLAATFVLLRNANALANPLDTPVWLLSGLLVPVTVLPAWTHPVSWALPTTWGARAVHAATSGGDVLTPLLAAAALGAGYALAAVLVLGRVERRARAAATLALT
>NZ_CP029196.1|WP_150160919.1|3481798_3482131_-|hypothetical-protein
MTVETAMALPVLALFTVTLLWGLAAAAAQIRCVDAARAGARVAARAEPVASAEAAARASAPEGARVSVTRSGELWRVTVEAAAPGPRGMGLTLRADAAALAEDTVSEGPP
>NZ_CP029196.1|WP_150163622.1|3482141_3482372_-|DUF4244-domain-containing-protein
MVKARRARAVAWVAVRGWWRRRCQAARSDAGMTTSEYAVGTIAAAGFAAVLYKIVTSGAVSGALESVIGKALDAPF
>NZ_CP029196.1|WP_150160920.1|3482506_3483289_-|type-II-secretion-protein-F
MIEHAERGALAAAAVIGCAQGVRELVRARRVRGMRRRVRTLLPVPASARAPAPRSPKSRSGPLGRVGRWAAPLGAAGLGWVLFGAIGGVPAGALVAAWVRRASMRGPSPAGDEDEAVRHLPLAADLLAACASAGAGPGEAAEAVGRSLGGPLGERLTRTAAELRLGGEPAEVWRRFGAIPGAEGLARCMERAGSSGAPAAEAVARHAAALRSARARAAAVRARRAQVLISAPVGLCFLPAFLAVGVAPVVIGLATGLLAG
>NZ_CP029196.1|WP_150160921.1|3483285_3484251_-|hypothetical-protein
MTERLPHAHAVAQVAWVACAVLALRWAAERRRGAGRARALLALADAAGAGARGVDSARGVRGVGRARGFGDLRGLLDRRRAGWPAVVAGWWAVLRPRRAWLCLPAAGALALLGASPLPLVAGALAVPLVERRLGAAERRKEREARAERVVSLCGAVVGELRAGWQPAQALSFAARETGALGAEEAAVLAAARFGGDVPAALRKAADQDGADGLAGMAACWQVAVDGGAGLAAGLDRLEAALRDHREQRERLRAELAGAWATVAVLAVLPLAGVALGAALGADPLRVLLHTPAGLGCLVVGGALEAAGLWWAARIVRGGERE
>NZ_CP029196.1|WP_150160922.1|3484250_3485423_-|TadA-family-conjugal-transfer-associated-ATPase
MTGVSSAGGGAGLLDAVRQRLAASGSEPTPARVAAALRAQGRLLGDAEVLGAAEELRCELIGTGPLEPLLADPAVTDVLVSAPDRVWVDRGAGLERAPVSFPDALAVRRLAQRLAAVAGRRLDDARPWVDARLPDGTRMHAVLPPVAVGSTCLSLRVVRPRAFTLEELAAAGTVPPGGAPILRALIDARVSYLVSGGTGTGKTTLLASLLGLVGERERIVLAEDSAELRPDHPHVVRLEARPANQEGAGLVTLRDLVRQALRMRPDRLVVGEVRGGEAVDLLAALNTGHEGGSGTVHANTAADVPARLEALGTAAGLDRAALHSQLSAGLSVVLHLARDRDGRRRIAEAHVLERDRDGLVRTVPALRWGTTGFTRERGWERLKALIGGGS
>NZ_CP029196.1|WP_150163623.1|3485419_3486508_-|septum-formation-initiator
MGGAAGPDEPRRTGPLIVTEDLGLLDDLLRLCAAAGVEPEVHHRVPERRASWTDPPLVLVGDDVAARCRGAARRPGTVLVGRDRDDPAVWRLAVEIGAESVLRLPDAEGVLVDRIADAAEGVGRQALTVGVVGGRGGAGASTLACGLALAAVRTGHRTLLVDGDPLGGGLDVLLGGEREDGRRWPDFAASKGRLAGGALEESLPSVRGVRVLSWGREPAAPLPPEAVRSVLAAARRRGGVVVVDLPRAADAAAAEAVTQLDLGLLVVPGELRSVAAAHRVAFALSAGVRDLRAVVRGPYAAGLDERWIADALRLPLVGELPYDPGIVADQDAGMPPGAEPRGPLGRFCDAFWTRALAPGGAA
>NZ_CP029196.1|WP_150160923.1|3487070_3487937_+|HAD-IB-family-hydrolase
MLRLVENHSLPRTAAFFDLDKTVIAKSSTLTFSKSFYRGGLISRRAALRTAYIQFVFLAGGADHDQMERMREYLSALCKGWNVAQVKELVAETLHDLIDPIIYDEAASLIEGHHAAGRDVVIVSTSGAEVVEPIGEMLGADRVVATRMVVGEDGCFTGEVEYYAYGPTKADAVRELAASEGYDLSRCYAYSDSATDIPMLEAVGHPYAVNPDRTLRREAVARDWPVLAFEKPVRLKQRLPEFRMPPRPTLVAAAAVGAAAVGAGLVWYAARRRQAALAHRLADDFARI
>NZ_CP029196.1|WP_041662552.1|3488277_3489096_-|Fic-family-protein
MSTHASDPLAALGSLPGVADAVDSVRKAVDRVYGHRVMRRRSNEISSEAALRGARGSAALSGADWALEEVRRRTDFGSDAEARTVGAALRLGAEAGQLLSIWRQSPLRVLARLHLVAAGDPGESVGRPRLDGETVDEPLVEAPLPTPAEVAGRLDGLAELIVAGGEAPALVTAAVVHGELLALRPFTTHNGLVARAAERIVLVGSGLDPKAICPAEVGHAEQGRAAYLAAFEGYLSGTPEGVGGWIAHCGRSVELGVRESTAVCEALQRGAA
>NZ_CP029196.1|WP_150160924.1|3489198_3490185_+|ATP-binding-protein
MKIAFVGKGGSGKTTLSSLFIRHLAANEAPVVAVDADINQHLGAALGLPDAEAAALPAMGAHLPLIKEYLRGSNPRIASADTMIKTTPPGDGSRLLRVREENPVYEACARTVGLDDGDIRLMATGPFTESDLGVSCYHSKVGAVELCLNHLVDGPDEYVVVDMTAGSDSFASGLFTRFDMTFLVAEPTRKGVSVYRQYKEYARDFGVALKVVGNKVQGQDDLDFLRAEVGEDLLVTVGHSDWVRAMEKGRPPRFDLLEAENRMSLQALQDAADDSYTARDWERYTRQMVHFHLRNAESWGNAKTGADLAAQVDPDFVLTESLSAVQPA
>NZ_CP029196.1|WP_150160925.1|3490162_3491470_-|hypothetical-protein
MTAAGRRTTAQRKALAAGALAVALITGLAGCSGSDGTATKGTPGGAGAKKGPAAAPNAVRLIGDGSTAYTGAQPRQPVWQRLKPGETPPQFVVFSWDGAGEDSQKLFSHFRAVGKKYDATMTYFLSGVYLLPEEKKALYDPPQHSPGRSDIGFNDTEGIRATVRELRGAWQEGNEIGTHFNGHFCGADGGVGTWSVDEWKSEIKQAKSFVKNWKTNSGLRTEQPLPFDYDKELVGARTPCLEGRKNFVRAAAELGFRYDTSGVNDQIWPKKDLGLWDLSLQLVPVPGRAFQTLSMDYNFLVNQSPGTTQGDPSQREYWGNQMRDGLVQAFQRSYQGNRAPLIIGNHFESWNGGTYMRAIEETIATVCVQKDVKCVSFRQLADWLDAQDPDVIAKMRTLKVGQAPPAGWKAFLAPQPATPPAPSGAAGAAKPAERR

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Crispr_ID: NZ_CP029196_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_12

4337545-4337612

Orphan

Consensus_repeat	Method
CAGGTCCTGCGCCTCGTCGAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_12

>merge|NZ_CP029196|12|4337545-4337612|CRISPRCasFinder
CAGCTTCTGCTCGTCCTCGTCGAACAGCCCCTCGGCGTGCTCCGCGAGGAACTCCGCGTCGCCGAGCA

>NZ_CP029196|12|8|4337545-4337612|CRISPRCasFinder
CAGCTTCTGCTCGTCCTCGTCGA	ACAGCCCCTCGGCGTGCTCCGC
GAGGAACTCCGCGTCGCCGAGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_015035316.1\|4329771_4330053_-\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385
NZ_CP029196.1\|WP_150161432.1\|4328302_4329214_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320685
NZ_CP029196.1\|WP_150161437.1\|4335622_4336195_-\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NZ_CP029196.1\|WP_150161444.1\|4346341_4347409_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP029196.1\|WP_150161445.1\|4347405_4348410_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|223682
NZ_CP029196.1\|WP_150161442.1\|4344220_4345309_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029196.1\|WP_041662734.1\|4348561_4349188_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP029196.1\|WP_150161441.1\|4340991_4341570_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NZ_CP029196.1\|WP_071891443.1\|4349175_4349487_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161435.1\|4332912_4333890_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161433.1\|4330090_4332358_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP029196.1\|WP_150161443.1\|4345490_4346345_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP029196.1\|WP_150161434.1\|4332443_4332728_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NZ_CP029196.1\|WP_150161436.1\|4334699_4335626_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|270704
NZ_CP029196.1\|WP_015035320.1\|4333941_4334631_+\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|281866
NZ_CP029196.1\|WP_150163670.1\|4341622_4344115_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|379300
NZ_CP029196.1\|WP_041664095.1\|4329210_4329600_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP029196.1\|WP_150161438.1\|4336282_4336756_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319906
NZ_CP029196.1\|WP_015035325.1\|4339220_4340861_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP029196.1\|WP_150161440.1\|4339028_4339217_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015035316.1\|4329771_4330053_-\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	1.99109e-29
NZ_CP029196.1\|WP_150161432.1\|4328302_4329214_-\|M48-family-metalloprotease	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	7.88154e-30
NZ_CP029196.1\|WP_150161437.1\|4335622_4336195_-\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	2.6973e-32
NZ_CP029196.1\|WP_150161444.1\|4346341_4347409_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	3.57722e-77
NZ_CP029196.1\|WP_150161445.1\|4347405_4348410_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	5.65865e-81
NZ_CP029196.1\|WP_150161442.1\|4344220_4345309_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.3651e-05
NZ_CP029196.1\|WP_041662734.1\|4348561_4349188_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.03321e-27
NZ_CP029196.1\|WP_150161441.1\|4340991_4341570_+\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	3.39005e-19
NZ_CP029196.1\|WP_150161433.1\|4330090_4332358_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP029196.1\|WP_150161443.1\|4345490_4346345_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.35977e-132
NZ_CP029196.1\|WP_150161434.1\|4332443_4332728_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	7.23471e-14
NZ_CP029196.1\|WP_150161436.1\|4334699_4335626_+\|phosphotransferase	gnl\|CDD\|270704	cd05155, APH_ChoK_like_1, Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase. This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	2.71423e-95
NZ_CP029196.1\|WP_015035320.1\|4333941_4334631_+\|copper-homeostasis-protein-CutC	gnl\|CDD\|281866	pfam03932, CutC, CutC family. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	7.03004e-25
NZ_CP029196.1\|WP_150163670.1\|4341622_4344115_-\|DNA-binding-protein	gnl\|CDD\|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	2.10223e-40
NZ_CP029196.1\|WP_041664095.1\|4329210_4329600_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	4.55573e-27
NZ_CP029196.1\|WP_150161438.1\|4336282_4336756_-\|glyoxalase	gnl\|CDD\|319906	cd07242, VOC_BsYqjT, vicinal oxygen chelate (VOC) family protein similar to Bacillus subtilis YqjT. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.96638e-39
NZ_CP029196.1\|WP_015035325.1\|4339220_4340861_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	2.2161e-108

>NZ_CP029196.1|WP_150161438.1|4336282_4336756_-|glyoxalase
MSPAGALHHVEVWVGDLARAEDSFGWLLGTLGYEPFQRWEGGRSWALGSFYLVVEQSPARTSDVHDRLRPGLNHLAFHAGDRTAVDALVAEAPAHGWRLLFADRHPYAGGEGVYAAYLENADGFEVELVAAPEEPGERGEPGAPGESGAPREDAGER
>NZ_CP029196.1|WP_150161437.1|4335622_4336195_-|dihydrofolate-reductase-family-protein
MRTLISSAFVSLDGVMEAPGGEEGYRNAGWTFKDVEFVPEAYAIKGREQEEAAAMLFGRASYEAFSAVWPDMEDFARYKTLPKYVVSTTLTEDDLADNWGETTILRSLDEVAALKETEGGPIIMHGSASLGRALSDAGLIDRYHLLVFPLLLGAGKRLFSGTDKDTQKLKLVEHETYANGIQKNVFDVVR
>NZ_CP029196.1|WP_150161436.1|4334699_4335626_+|phosphotransferase
MAVTSPPTSPEGPVGVEFVGRLVAGRFPEWGGLPVRAVPSAGTDNVMFRLGDDLVVRLPRVAYAARHVEKEQRWLPLLAPHLPLAVPVPVGRAEPGPEFPYPWSVYRWLDGDDTYNAPLTDLAHAAVELGRFGAALRAVDASDGPASFRGGPVTAWEEGQLPAAVRDLAADGLVDAGLATAAWEAVLRLPQWDGPPVWVHGDLLPGNLLGRGGRLSAVIDFGGLGTGDPACDTLPAWTLFTAATRPLFREAARVDDATWARGRGWALAWGLVTEHHYRGRNEVLAAVARRTRTEALAEYAELAGATAS
>NZ_CP029196.1|WP_015035320.1|4333941_4334631_+|copper-homeostasis-protein-CutC
MSNRAVLEVIALDEEDAVAAQTGGADRLELVTDMAADGLTPSRTGFAAIRAAVDIPLRVMLRLTDGFAAGDVDALVARAQELRAAGADEFVLGFLTAEGEPDLVAVERLIAVLDGCRWTFHRAIDRAADRDGLRKRLADLPGLDTYLTAGSATGVDDGLATLKAEAARRGEPGYEAQILVGGGLRLDHLPELRAAGLDAFHIGGAARPHGWTSPVSAAAVRAWREALDG
>NZ_CP029196.1|WP_150161435.1|4332912_4333890_+|hypothetical-protein
MNTGVKITAFAAALAATFGTAYGVGKGVGPVEEPKKAEHGDHAAAPTPTGSTAADGHAGHGPQTPATGTAAELPGGLQVSQDGYTLALETPVPAAGKSVLKFSIKDAAGRKVTAFTTEHGKELHFIVASRDLNTFRHLHPVKAADGTWSVDADLPAAGGYKAFADFKPAAPGAKGVTLGADLSVPGAYAPKPLPAVAPTATVDGYQVRLGGVLDPGKAGELKLTVTKGGKPVTDLEPYLGAYGHLVALRDGDLAYLHVHPNEGGPGPDVSFTATAPSAGTYRLFLDFQHEGKVRTASFTVTTGGGNASVPTTGEATHDAGGHAHG
>NZ_CP029196.1|WP_150161434.1|4332443_4332728_-|heavy-metal-associated-domain-containing-protein
MGSCCTPDNSCSTTAETTAVAVADSTTTVYAVSGMTCGHCKTAITKSVSALDGVISVDVDVAGGLVTVTTGGEPDDTAITAAVDDAGYELTGRA
>NZ_CP029196.1|WP_150161433.1|4330090_4332358_-|cadmium-translocating-P-type-ATPase
MNTTTPGTAQVELAIGGMTCASCAARIEKKLNRMDGVEATVNYATEKAKVTFDADIDVADLIATVEATGYTAAEPAPPRSETPGAPDGPSDEERADEELRPLKQRLITAVALAVPVIAMAMVPALQIEYWQWLSLTLAAPVVVYAAWPFHRAAWTNARHGAATMDTLISVGTIAAFLWSLWALFFGTAGTPGMTHPFEFTIARTDGAGNIYLEAAAGVTAFILAGRYFEARSKRKAGAALKALMQLGAKEVTVLKDGREVTVPTGELQVGDRFLVRPGEKIATDGTVVEGSSAVDASMLTGESVPVEVSVGDSVTGATLNAGGRLVVEATRVGSDTQLARMAKLVEDAQNGKAAAQRLADRISAVFVPIVIALALGTLGFWLGTGQGLTAAFTAAVAVLIIACPCALGLATPTALMVGTGRGAQLGILIKGPEVLETTRKVDTIVLDKTGTVTTGRMTLLKVHTAEGTDETDVLRLAGALEHSSEHPIAQAVATGAAAKVGTLPTPEDFANIPGLGVQGVVEGHAVLVGREKLLDEWAMALPADLKSAKDTAEKAGRTAIAVAWDGEARAVLEVADAVKETSAEAIRRLRGLGLTPILLTGDNEAVARAVAAEVGIGEVIAEVMPQDKVDVVKRLQAEGRSVAMVGDGVNDAAALAQADLGLAMGTGTDAAIEAGDLTLVRGDLRAAADAIRLSRRTLGTIRSNLFWAFAYNVAALPLAAAGLLNPMIAGAAMAFSSVFVVGNSLRLRGFQAADR
>NZ_CP029196.1|WP_015035316.1|4329771_4330053_-|metal-sensitive-transcriptional-regulator
MAGYGQHKEDIIRRLRRIEGQVRGVQRMVDEDVYCIDVLTQVSAINAALQSCAVALLDEHLSCCVTEAIAQGGDQAKVKVGEASKAIARLIRT
>NZ_CP029196.1|WP_041664095.1|4329210_4329600_-|BlaI/MecI/CopY-family-transcriptional-regulator
MRRLGELEAEIMDRLWAWQRPATVREVVDDINRGRRVAYTTVMTVADILHRKGWLRREKAGRAWLYEPVRSREEYTAGLMRDALGDSQDRPAALLRFVEVISDEDMDALDAALRAARGDQEPHPGGSAA
>NZ_CP029196.1|WP_150161432.1|4328302_4329214_-|M48-family-metalloprotease
MNHHLLVPLGIVALTGFLVPWLVVRARWAQQAPRLALAVWAACGALFAAATALVPAQLVLPIESSHRLADMMYALRPPTVGQLLHLDGRERFAFALSLAVLSLPAAAFVRRLARARRMRVRHAGVLRLVGRYDPALRATVLDDDRPAVYCLPGRSRRVVVSSGAVDTLTPAQLAAALAHERAHISGRHHLLVAATEAFAAVFARLPLARHGGAAVPLLLEMAADDRALRRCTRDALATALYALASGRAPRSAFAAGGPSAALRMRRILTPHSAGHPVLRGLLTVGAAGLAITPLIVACCSFPG
>NZ_CP029196.1|WP_150161440.1|4339028_4339217_+|hypothetical-protein
MTATTFTLVTTVPRPRVRPLGTALRALRAFGGAAAGVVLLGDYGPPEAGVRNPRPVYAPGPD
>NZ_CP029196.1|WP_015035325.1|4339220_4340861_-|DEAD/DEAH-box-helicase
MSGPLIVQSDKTLLLEVDHELADDCRRAIAPFAELERAPEHIHTYRLTPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMDRYGRLTLSKHPAHGLVLTSTDRPVLEEILRSRKVQPLVGERIDPDTVVVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHRIDLAEDGWALRPYQKQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAQAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTKRKGIYPHLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAEAEEKYRFCATTATKRKVTEALVKKFEGQQILVIGQYIDQLDELGEHLDAPVIKGETPNAQREKLFDAFRTGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHQAHFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADELLGS
>NZ_CP029196.1|WP_150161441.1|4340991_4341570_+|Uma2-family-endonuclease
MSVAHDPHYGPWTIEEVLALGEDRGQRRELMGEALVMSPAPGFKHQRASLRLAMLLDQAVQASGRPAEVLEAINLILPDGLFIPDIVVVEAAASAENPVTCDADDVLLVVEIVSPSSSGRRTDRLLKPPYYAEAGIEHLWRLELEPVPTLVVCELQDGRYVERTVAEVGRTTLIEKPFPLEVDPAALVSPRT
>NZ_CP029196.1|WP_150163670.1|4341622_4344115_-|DNA-binding-protein
MPEVSGAAAAPRTLAEALRARGDEGLAALLRARPDLLNPVPNDLTQLATRAGTRGSVVRALERLDRFALQTAEALAVAPDPAPYPVLLGLLTGDEGDPEIEAALPGAVALLREQALVWGEDDRLRLVRTARELLAPSAQHPSPTGLGPTVAEATSGMSPGRVQEIIAAAGLSATHDAVSAVAALTALFTDRARMGALLDTAPPEALAVLDRLVWGPPYGEVTAKPAAPVQWLRDHGLLLPVSPRTMVLPREVALHLRGGRAHRSPEPRAPEPAVLREYRPQVVDSAAAGQAQLALATVEELLKSWDRGGPPVLRAGGLAVRDLKRTAAALDVSEETAAFWLELCYGAGLLASDGEADERYAPTPAYDDWLDLPPAERWALLVTPWLSATRTPGLVGGQDAKGRALSALGPDLDRAPAPEVRHRVLGLLATLPPGSAVEPESLFARLRWERPLRGAAAAGDGDDLRSRLARWTLAEAELLGLTGRGALSGPARALLNLPLAEAASPGEPGGGVEPAVAAGRAATLLAPLLPEPVDHVLLQADLTAVAPGPLRRPLADALAVLADVESKGGATVYRFTPGSVRRALDSGQTATDLHEFLKAHARTPVPQPLTYLVDDVARRHGHLRVGAASAYVRCDDDTVLGEILADRRSSSLGLRRIAPTVLAAQTDPASLLEGLRSMGYAPAAESATGDVLITRADAYRTPARTAPVPVPDGPPAPDTTLLGAAVRAIRAGDRAATAVRKEPAAAPTAAGALPRTSAAETLATVQAAAMTGSAVWIGYVNAEGGASQRVIAPVRVEGGFVTAYDHTADEVRTYPLHRITGVAELADDQV
>NZ_CP029196.1|WP_150161442.1|4344220_4345309_+|hypothetical-protein
MGIESDQLVYDYLSRVGDLAQQRQLPASERMRLVSTLRNEIDRRRATYGEESPAAVRRILGTLGTPDEVVERAEGPGAPPAPSAPAPAPAPVPKPRKEGRPGRAGRAAGWLPGSRRSREGSGKPKPAPRTPAPGASVSGASAGADAPAASDLTGLDATGGLLDDTSDWWQQEDPAEGLPGFVGGVERPDLFEEPVPDEDEHEDGEGDEEDDAEAPSRGRRLARVLLRRKPRAAAEAYGTEEEPDAAPVSRLRLANPFVLLAALLLLGGALIGSPVVLALGWLLAYGSRRLTPGEVKAAVLVIPGLAAASGVVWLWGRVEGRWGDPVGAGGEAMGAAVSETWPWALRGAAVASALFLIWRSRR
>NZ_CP029196.1|WP_150161443.1|4345490_4346345_-|ATP-binding-cassette-domain-containing-protein
MSRLTARELTLAYEDRTVVHELDLAIPDGKVTVIVGPNACGKSTTLRALGRLLRPAGGAVLLDGEELAKLPTKRIARSIGLLPQTPVAPEAITVADLVSRGRQPHQAWWKQWSEEDERAVTEAMDRTDVAALADRSVDELSGGQRQRVWIAMALAQETDLLLLDEPTTYLDICHQVEVLDLVRRLNRLRGRTVVVVLHDLNQAARYADHLVAMKAGRVVAEGPPPEIVTEQLVRDVFGLSSVVVPDPVTGSPLVVPGAPWEGDGAVSGAGAGAVTSAGTNTVKG
>NZ_CP029196.1|WP_150161444.1|4346341_4347409_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTAPTLVRPAGYGTVRAGRASFLVHRRSALVAVGLLLLLAVSSVAYLCVGERFVGPSEVLRVLLGQPSPSAFVVAELREPRLVVALAVGAAFGVAGALIQTVARNPLASPDIIGISQGAGAVTVAAMTFGLTSYTVLPYLSIAGGVLAAALVYAFAWRGGLHATRFVLIGIGFAIALRSLTTLFMTKGDYLVAQQAQIWMTGSLNGRGWDESAPIRWTLLLMLPAVLWAARAQRTVSLDDDTATALGVRLGPVRLGLVAVGVVLASVATGVAGPVDFVALLAPQIARRMTRTPQIPLLCSALAGAVVVVLADLIGRRLFSPVELPVGVLTAAVGAPYLIWLIVRSRAAGSSGGKA
>NZ_CP029196.1|WP_150161445.1|4347405_4348410_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MPAAFRTRRVLATSAALVALLVAVLLSLAVGARAIAPTTVLDALLHGGTSPDAEVVRQLRVPRTVIGLMVGAALALAGTALQGITRNPIADPGILGISQGSSVGVVLAIAFFGVHTLTGYVWFAFAGAALAAVAVHAVASSGRGGATPVKLALGGAAINALLLSVTTGILTTRASALDEFRFWQIGSLDGRDAQIVGQIWPFLLVGAVLVVSVARGLDALALGEDVAKGLGQRVATVRIVGGVGATVLTGAGVAAAGPVAFVGLAVPHIARAVVGSDHRWVLPMAAIIGPVMLLVADVAGRIVFPPGEVPAGVMTALIGVPFLVTLVRRKAVPA
>NZ_CP029196.1|WP_041662734.1|4348561_4349188_+|HAD-family-hydrolase
MTTSATRPPLTVGFDLDLTLIDTRPGIRAAWVAFSAESGVPVDADLVVSRLGPPLEHEMAYWVPEERVTEMVARYRALYPAYAIEPSAPMPGARDAIRAVREAGGRTIVVTAKNGPHAELHLAHLGIEPDAVVGGLWAEGKAEALRAHGAQVYVGDHVGDVRGAATAGALSVAVATGPCAPEELKEAGADVVLPDLTDFRSWWEGYLA
>NZ_CP029196.1|WP_071891443.1|4349175_4349487_-|hypothetical-protein
MFLRPGNYPGRMRSETPAAPANDSAPGDGLIKAGVILFAVGAVATLVTVAPLFLGTDPFPTVAYTVSMLMGVGFAVAAAGVLRSIAAQRRQARSGSTGPVQAR

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Crispr_ID: NZ_CP029196_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_11

4337404-4337481

Orphan

Consensus_repeat	Method
CAGGTCCTGCGCCTCGTCGAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_11

>merge|NZ_CP029196|11|4337404-4337481|CRISPRCasFinder
CAGGTCCTGCGCCTCGTCGAGGACCACGTGCCCGAGCGAGTGCGTCCGCTCCACCAGGTCCTGCGCCTCGTCGATGAG

>NZ_CP029196|11|7|4337404-4337481|CRISPRCasFinder
CAGGTCCTGCGCCTCGTCGAGGA	CCACGTGCCCGAGCGAGTGCGTCCGCTCCAC
CAGGTCCTGCGCCTCGTCGATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_015035316.1\|4329771_4330053_-\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385
NZ_CP029196.1\|WP_150161432.1\|4328302_4329214_-\|M48-family-metalloprotease	unknown	unknown	gnl\|CDD\|320685
NZ_CP029196.1\|WP_150161437.1\|4335622_4336195_-\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NZ_CP029196.1\|WP_150161444.1\|4346341_4347409_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP029196.1\|WP_150161445.1\|4347405_4348410_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|223682
NZ_CP029196.1\|WP_150161442.1\|4344220_4345309_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029196.1\|WP_041662734.1\|4348561_4349188_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP029196.1\|WP_150161441.1\|4340991_4341570_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|99749
NZ_CP029196.1\|WP_071891443.1\|4349175_4349487_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161435.1\|4332912_4333890_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161433.1\|4330090_4332358_-\|cadmium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP029196.1\|WP_150161443.1\|4345490_4346345_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP029196.1\|WP_150161434.1\|4332443_4332728_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NZ_CP029196.1\|WP_150161436.1\|4334699_4335626_+\|phosphotransferase	unknown	unknown	gnl\|CDD\|270704
NZ_CP029196.1\|WP_015035320.1\|4333941_4334631_+\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|281866
NZ_CP029196.1\|WP_150163670.1\|4341622_4344115_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|379300
NZ_CP029196.1\|WP_041664095.1\|4329210_4329600_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP029196.1\|WP_150161438.1\|4336282_4336756_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319906
NZ_CP029196.1\|WP_015035325.1\|4339220_4340861_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP029196.1\|WP_150161440.1\|4339028_4339217_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015035316.1\|4329771_4330053_-\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	1.99109e-29
NZ_CP029196.1\|WP_150161432.1\|4328302_4329214_-\|M48-family-metalloprotease	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	7.88154e-30
NZ_CP029196.1\|WP_150161437.1\|4335622_4336195_-\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	2.6973e-32
NZ_CP029196.1\|WP_150161444.1\|4346341_4347409_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	3.57722e-77
NZ_CP029196.1\|WP_150161445.1\|4347405_4348410_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	5.65865e-81
NZ_CP029196.1\|WP_150161442.1\|4344220_4345309_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.3651e-05
NZ_CP029196.1\|WP_041662734.1\|4348561_4349188_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.03321e-27
NZ_CP029196.1\|WP_150161441.1\|4340991_4341570_+\|Uma2-family-endonuclease	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	3.39005e-19
NZ_CP029196.1\|WP_150161433.1\|4330090_4332358_-\|cadmium-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP029196.1\|WP_150161443.1\|4345490_4346345_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.35977e-132
NZ_CP029196.1\|WP_150161434.1\|4332443_4332728_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	7.23471e-14
NZ_CP029196.1\|WP_150161436.1\|4334699_4335626_+\|phosphotransferase	gnl\|CDD\|270704	cd05155, APH_ChoK_like_1, Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase. This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	2.71423e-95
NZ_CP029196.1\|WP_015035320.1\|4333941_4334631_+\|copper-homeostasis-protein-CutC	gnl\|CDD\|281866	pfam03932, CutC, CutC family. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	7.03004e-25
NZ_CP029196.1\|WP_150163670.1\|4341622_4344115_-\|DNA-binding-protein	gnl\|CDD\|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	2.10223e-40
NZ_CP029196.1\|WP_041664095.1\|4329210_4329600_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	4.55573e-27
NZ_CP029196.1\|WP_150161438.1\|4336282_4336756_-\|glyoxalase	gnl\|CDD\|319906	cd07242, VOC_BsYqjT, vicinal oxygen chelate (VOC) family protein similar to Bacillus subtilis YqjT. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.96638e-39
NZ_CP029196.1\|WP_015035325.1\|4339220_4340861_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	2.2161e-108

>NZ_CP029196.1|WP_150161438.1|4336282_4336756_-|glyoxalase
MSPAGALHHVEVWVGDLARAEDSFGWLLGTLGYEPFQRWEGGRSWALGSFYLVVEQSPARTSDVHDRLRPGLNHLAFHAGDRTAVDALVAEAPAHGWRLLFADRHPYAGGEGVYAAYLENADGFEVELVAAPEEPGERGEPGAPGESGAPREDAGER
>NZ_CP029196.1|WP_150161437.1|4335622_4336195_-|dihydrofolate-reductase-family-protein
MRTLISSAFVSLDGVMEAPGGEEGYRNAGWTFKDVEFVPEAYAIKGREQEEAAAMLFGRASYEAFSAVWPDMEDFARYKTLPKYVVSTTLTEDDLADNWGETTILRSLDEVAALKETEGGPIIMHGSASLGRALSDAGLIDRYHLLVFPLLLGAGKRLFSGTDKDTQKLKLVEHETYANGIQKNVFDVVR
>NZ_CP029196.1|WP_150161436.1|4334699_4335626_+|phosphotransferase
MAVTSPPTSPEGPVGVEFVGRLVAGRFPEWGGLPVRAVPSAGTDNVMFRLGDDLVVRLPRVAYAARHVEKEQRWLPLLAPHLPLAVPVPVGRAEPGPEFPYPWSVYRWLDGDDTYNAPLTDLAHAAVELGRFGAALRAVDASDGPASFRGGPVTAWEEGQLPAAVRDLAADGLVDAGLATAAWEAVLRLPQWDGPPVWVHGDLLPGNLLGRGGRLSAVIDFGGLGTGDPACDTLPAWTLFTAATRPLFREAARVDDATWARGRGWALAWGLVTEHHYRGRNEVLAAVARRTRTEALAEYAELAGATAS
>NZ_CP029196.1|WP_015035320.1|4333941_4334631_+|copper-homeostasis-protein-CutC
MSNRAVLEVIALDEEDAVAAQTGGADRLELVTDMAADGLTPSRTGFAAIRAAVDIPLRVMLRLTDGFAAGDVDALVARAQELRAAGADEFVLGFLTAEGEPDLVAVERLIAVLDGCRWTFHRAIDRAADRDGLRKRLADLPGLDTYLTAGSATGVDDGLATLKAEAARRGEPGYEAQILVGGGLRLDHLPELRAAGLDAFHIGGAARPHGWTSPVSAAAVRAWREALDG
>NZ_CP029196.1|WP_150161435.1|4332912_4333890_+|hypothetical-protein
MNTGVKITAFAAALAATFGTAYGVGKGVGPVEEPKKAEHGDHAAAPTPTGSTAADGHAGHGPQTPATGTAAELPGGLQVSQDGYTLALETPVPAAGKSVLKFSIKDAAGRKVTAFTTEHGKELHFIVASRDLNTFRHLHPVKAADGTWSVDADLPAAGGYKAFADFKPAAPGAKGVTLGADLSVPGAYAPKPLPAVAPTATVDGYQVRLGGVLDPGKAGELKLTVTKGGKPVTDLEPYLGAYGHLVALRDGDLAYLHVHPNEGGPGPDVSFTATAPSAGTYRLFLDFQHEGKVRTASFTVTTGGGNASVPTTGEATHDAGGHAHG
>NZ_CP029196.1|WP_150161434.1|4332443_4332728_-|heavy-metal-associated-domain-containing-protein
MGSCCTPDNSCSTTAETTAVAVADSTTTVYAVSGMTCGHCKTAITKSVSALDGVISVDVDVAGGLVTVTTGGEPDDTAITAAVDDAGYELTGRA
>NZ_CP029196.1|WP_150161433.1|4330090_4332358_-|cadmium-translocating-P-type-ATPase
MNTTTPGTAQVELAIGGMTCASCAARIEKKLNRMDGVEATVNYATEKAKVTFDADIDVADLIATVEATGYTAAEPAPPRSETPGAPDGPSDEERADEELRPLKQRLITAVALAVPVIAMAMVPALQIEYWQWLSLTLAAPVVVYAAWPFHRAAWTNARHGAATMDTLISVGTIAAFLWSLWALFFGTAGTPGMTHPFEFTIARTDGAGNIYLEAAAGVTAFILAGRYFEARSKRKAGAALKALMQLGAKEVTVLKDGREVTVPTGELQVGDRFLVRPGEKIATDGTVVEGSSAVDASMLTGESVPVEVSVGDSVTGATLNAGGRLVVEATRVGSDTQLARMAKLVEDAQNGKAAAQRLADRISAVFVPIVIALALGTLGFWLGTGQGLTAAFTAAVAVLIIACPCALGLATPTALMVGTGRGAQLGILIKGPEVLETTRKVDTIVLDKTGTVTTGRMTLLKVHTAEGTDETDVLRLAGALEHSSEHPIAQAVATGAAAKVGTLPTPEDFANIPGLGVQGVVEGHAVLVGREKLLDEWAMALPADLKSAKDTAEKAGRTAIAVAWDGEARAVLEVADAVKETSAEAIRRLRGLGLTPILLTGDNEAVARAVAAEVGIGEVIAEVMPQDKVDVVKRLQAEGRSVAMVGDGVNDAAALAQADLGLAMGTGTDAAIEAGDLTLVRGDLRAAADAIRLSRRTLGTIRSNLFWAFAYNVAALPLAAAGLLNPMIAGAAMAFSSVFVVGNSLRLRGFQAADR
>NZ_CP029196.1|WP_015035316.1|4329771_4330053_-|metal-sensitive-transcriptional-regulator
MAGYGQHKEDIIRRLRRIEGQVRGVQRMVDEDVYCIDVLTQVSAINAALQSCAVALLDEHLSCCVTEAIAQGGDQAKVKVGEASKAIARLIRT
>NZ_CP029196.1|WP_041664095.1|4329210_4329600_-|BlaI/MecI/CopY-family-transcriptional-regulator
MRRLGELEAEIMDRLWAWQRPATVREVVDDINRGRRVAYTTVMTVADILHRKGWLRREKAGRAWLYEPVRSREEYTAGLMRDALGDSQDRPAALLRFVEVISDEDMDALDAALRAARGDQEPHPGGSAA
>NZ_CP029196.1|WP_150161432.1|4328302_4329214_-|M48-family-metalloprotease
MNHHLLVPLGIVALTGFLVPWLVVRARWAQQAPRLALAVWAACGALFAAATALVPAQLVLPIESSHRLADMMYALRPPTVGQLLHLDGRERFAFALSLAVLSLPAAAFVRRLARARRMRVRHAGVLRLVGRYDPALRATVLDDDRPAVYCLPGRSRRVVVSSGAVDTLTPAQLAAALAHERAHISGRHHLLVAATEAFAAVFARLPLARHGGAAVPLLLEMAADDRALRRCTRDALATALYALASGRAPRSAFAAGGPSAALRMRRILTPHSAGHPVLRGLLTVGAAGLAITPLIVACCSFPG
>NZ_CP029196.1|WP_150161440.1|4339028_4339217_+|hypothetical-protein
MTATTFTLVTTVPRPRVRPLGTALRALRAFGGAAAGVVLLGDYGPPEAGVRNPRPVYAPGPD
>NZ_CP029196.1|WP_015035325.1|4339220_4340861_-|DEAD/DEAH-box-helicase
MSGPLIVQSDKTLLLEVDHELADDCRRAIAPFAELERAPEHIHTYRLTPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMDRYGRLTLSKHPAHGLVLTSTDRPVLEEILRSRKVQPLVGERIDPDTVVVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHRIDLAEDGWALRPYQKQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAQAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTKRKGIYPHLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAEAEEKYRFCATTATKRKVTEALVKKFEGQQILVIGQYIDQLDELGEHLDAPVIKGETPNAQREKLFDAFRTGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHQAHFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADELLGS
>NZ_CP029196.1|WP_150161441.1|4340991_4341570_+|Uma2-family-endonuclease
MSVAHDPHYGPWTIEEVLALGEDRGQRRELMGEALVMSPAPGFKHQRASLRLAMLLDQAVQASGRPAEVLEAINLILPDGLFIPDIVVVEAAASAENPVTCDADDVLLVVEIVSPSSSGRRTDRLLKPPYYAEAGIEHLWRLELEPVPTLVVCELQDGRYVERTVAEVGRTTLIEKPFPLEVDPAALVSPRT
>NZ_CP029196.1|WP_150163670.1|4341622_4344115_-|DNA-binding-protein
MPEVSGAAAAPRTLAEALRARGDEGLAALLRARPDLLNPVPNDLTQLATRAGTRGSVVRALERLDRFALQTAEALAVAPDPAPYPVLLGLLTGDEGDPEIEAALPGAVALLREQALVWGEDDRLRLVRTARELLAPSAQHPSPTGLGPTVAEATSGMSPGRVQEIIAAAGLSATHDAVSAVAALTALFTDRARMGALLDTAPPEALAVLDRLVWGPPYGEVTAKPAAPVQWLRDHGLLLPVSPRTMVLPREVALHLRGGRAHRSPEPRAPEPAVLREYRPQVVDSAAAGQAQLALATVEELLKSWDRGGPPVLRAGGLAVRDLKRTAAALDVSEETAAFWLELCYGAGLLASDGEADERYAPTPAYDDWLDLPPAERWALLVTPWLSATRTPGLVGGQDAKGRALSALGPDLDRAPAPEVRHRVLGLLATLPPGSAVEPESLFARLRWERPLRGAAAAGDGDDLRSRLARWTLAEAELLGLTGRGALSGPARALLNLPLAEAASPGEPGGGVEPAVAAGRAATLLAPLLPEPVDHVLLQADLTAVAPGPLRRPLADALAVLADVESKGGATVYRFTPGSVRRALDSGQTATDLHEFLKAHARTPVPQPLTYLVDDVARRHGHLRVGAASAYVRCDDDTVLGEILADRRSSSLGLRRIAPTVLAAQTDPASLLEGLRSMGYAPAAESATGDVLITRADAYRTPARTAPVPVPDGPPAPDTTLLGAAVRAIRAGDRAATAVRKEPAAAPTAAGALPRTSAAETLATVQAAAMTGSAVWIGYVNAEGGASQRVIAPVRVEGGFVTAYDHTADEVRTYPLHRITGVAELADDQV
>NZ_CP029196.1|WP_150161442.1|4344220_4345309_+|hypothetical-protein
MGIESDQLVYDYLSRVGDLAQQRQLPASERMRLVSTLRNEIDRRRATYGEESPAAVRRILGTLGTPDEVVERAEGPGAPPAPSAPAPAPAPVPKPRKEGRPGRAGRAAGWLPGSRRSREGSGKPKPAPRTPAPGASVSGASAGADAPAASDLTGLDATGGLLDDTSDWWQQEDPAEGLPGFVGGVERPDLFEEPVPDEDEHEDGEGDEEDDAEAPSRGRRLARVLLRRKPRAAAEAYGTEEEPDAAPVSRLRLANPFVLLAALLLLGGALIGSPVVLALGWLLAYGSRRLTPGEVKAAVLVIPGLAAASGVVWLWGRVEGRWGDPVGAGGEAMGAAVSETWPWALRGAAVASALFLIWRSRR
>NZ_CP029196.1|WP_150161443.1|4345490_4346345_-|ATP-binding-cassette-domain-containing-protein
MSRLTARELTLAYEDRTVVHELDLAIPDGKVTVIVGPNACGKSTTLRALGRLLRPAGGAVLLDGEELAKLPTKRIARSIGLLPQTPVAPEAITVADLVSRGRQPHQAWWKQWSEEDERAVTEAMDRTDVAALADRSVDELSGGQRQRVWIAMALAQETDLLLLDEPTTYLDICHQVEVLDLVRRLNRLRGRTVVVVLHDLNQAARYADHLVAMKAGRVVAEGPPPEIVTEQLVRDVFGLSSVVVPDPVTGSPLVVPGAPWEGDGAVSGAGAGAVTSAGTNTVKG
>NZ_CP029196.1|WP_150161444.1|4346341_4347409_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTAPTLVRPAGYGTVRAGRASFLVHRRSALVAVGLLLLLAVSSVAYLCVGERFVGPSEVLRVLLGQPSPSAFVVAELREPRLVVALAVGAAFGVAGALIQTVARNPLASPDIIGISQGAGAVTVAAMTFGLTSYTVLPYLSIAGGVLAAALVYAFAWRGGLHATRFVLIGIGFAIALRSLTTLFMTKGDYLVAQQAQIWMTGSLNGRGWDESAPIRWTLLLMLPAVLWAARAQRTVSLDDDTATALGVRLGPVRLGLVAVGVVLASVATGVAGPVDFVALLAPQIARRMTRTPQIPLLCSALAGAVVVVLADLIGRRLFSPVELPVGVLTAAVGAPYLIWLIVRSRAAGSSGGKA
>NZ_CP029196.1|WP_150161445.1|4347405_4348410_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MPAAFRTRRVLATSAALVALLVAVLLSLAVGARAIAPTTVLDALLHGGTSPDAEVVRQLRVPRTVIGLMVGAALALAGTALQGITRNPIADPGILGISQGSSVGVVLAIAFFGVHTLTGYVWFAFAGAALAAVAVHAVASSGRGGATPVKLALGGAAINALLLSVTTGILTTRASALDEFRFWQIGSLDGRDAQIVGQIWPFLLVGAVLVVSVARGLDALALGEDVAKGLGQRVATVRIVGGVGATVLTGAGVAAAGPVAFVGLAVPHIARAVVGSDHRWVLPMAAIIGPVMLLVADVAGRIVFPPGEVPAGVMTALIGVPFLVTLVRRKAVPA
>NZ_CP029196.1|WP_041662734.1|4348561_4349188_+|HAD-family-hydrolase
MTTSATRPPLTVGFDLDLTLIDTRPGIRAAWVAFSAESGVPVDADLVVSRLGPPLEHEMAYWVPEERVTEMVARYRALYPAYAIEPSAPMPGARDAIRAVREAGGRTIVVTAKNGPHAELHLAHLGIEPDAVVGGLWAEGKAEALRAHGAQVYVGDHVGDVRGAATAGALSVAVATGPCAPEELKEAGADVVLPDLTDFRSWWEGYLA
>NZ_CP029196.1|WP_071891443.1|4349175_4349487_-|hypothetical-protein
MFLRPGNYPGRMRSETPAAPANDSAPGDGLIKAGVILFAVGAVATLVTVAPLFLGTDPFPTVAYTVSMLMGVGFAVAAAGVLRSIAAQRRQARSGSTGPVQAR

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Crispr_ID: NZ_CP029196_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_13

4632949-4633040

Orphan

Consensus_repeat	Method
GCCCGGGGTGTACGGACCAGGGGCCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_13

>merge|NZ_CP029196|13|4632949-4633040|CRISPRCasFinder
GCCCGGGGTGTACGGACCAGGGGCCCGGGATGTACGGACCAGGGCCCGGGATGTACGGACCAGGGCCCGGGGTGTACGGACCAGGGGCCCGG

>NZ_CP029196|13|9|4632949-4633040|CRISPRCasFinder
GCCCGGGGTGTACGGACCAGGGGCCCGG	GATGTACGGACCAGGGCCCGGGATGTACGGACCAGG
GCCCGGGGTGTACGGACCAGGGGCCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150161589.1\|4627728_4628679_-\|DUF389-domain-containing-protein	unknown	unknown	gnl\|CDD\|129372
NZ_CP029196.1\|WP_150163682.1\|4638946_4639489_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_015035615.1\|4639609_4640266_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NZ_CP029196.1\|WP_150161587.1\|4623240_4624872_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP029196.1\|WP_041664125.1\|4632562_4632931_+\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|234610
NZ_CP029196.1\|WP_150161594.1\|4638101_4638602_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|376771
NZ_CP029196.1\|WP_015035617.1\|4640749_4641868_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_CP029196.1\|WP_015035604.1\|4628721_4629690_-\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466
NZ_CP029196.1\|WP_041664127.1\|4640289_4640760_+\|ribosomal-protein-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NZ_CP029196.1\|WP_015035606.1\|4630696_4632544_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP029196.1\|WP_150161592.1\|4635741_4636890_+\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NZ_CP029196.1\|WP_150161588.1\|4626258_4627617_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP029196.1\|WP_150161590.1\|4629781_4630657_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161586.1\|4622182_4623193_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|130689
NZ_CP029196.1\|WP_150161595.1\|4641864_4642119_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_015035600.1\|4625144_4625588_+\|50S-ribosomal-protein-L13	unknown	unknown	gnl\|CDD\|181703
NZ_CP029196.1\|WP_150161593.1\|4636900_4638091_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480
NZ_CP029196.1\|WP_041664126.1\|4633183_4634629_+\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	unknown	unknown	gnl\|CDD\|238576
NZ_CP029196.1\|WP_150161591.1\|4634833_4635721_+\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|341130
NZ_CP029196.1\|WP_015035601.1\|4625632_4626145_+\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150161589.1\|4627728_4628679_-\|DUF389-domain-containing-protein	gnl\|CDD\|129372	TIGR00271, Uncharacterized_protein_MJ0678, uncharacterized hydrophobic domain. This domain is in a family of archaeal proteins that includes AF0785 of Archaeoglobus fulgidus and in several eubacterial proteins, including the much longer protein sll1151 from Synechocystis PCC6803.	1.32292e-51
NZ_CP029196.1\|WP_015035617.1\|4640749_4641868_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	4.54846e-180
NZ_CP029196.1\|WP_015035615.1\|4639609_4640266_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	4.96346e-62
NZ_CP029196.1\|WP_150161587.1\|4623240_4624872_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	1.49488e-95
NZ_CP029196.1\|WP_041664125.1\|4632562_4632931_+\|holo-ACP-synthase	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	2.27365e-48
NZ_CP029196.1\|WP_150161594.1\|4638101_4638602_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	4.76176e-46
NZ_CP029196.1\|WP_015035604.1\|4628721_4629690_-\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NZ_CP029196.1\|WP_041664127.1\|4640289_4640760_+\|ribosomal-protein-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	2.0666e-24
NZ_CP029196.1\|WP_015035606.1\|4630696_4632544_+\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
NZ_CP029196.1\|WP_150161592.1\|4635741_4636890_+\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	4.74965e-164
NZ_CP029196.1\|WP_150161588.1\|4626258_4627617_+\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP029196.1\|WP_150161586.1\|4622182_4623193_-\|hypothetical-protein	gnl\|CDD\|130689	TIGR01628, Polyadenylate-binding_protein_3, polyadenylate binding protein, human types 1, 2, 3, 4 family. These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.	7.41305e-05
NZ_CP029196.1\|WP_015035600.1\|4625144_4625588_+\|50S-ribosomal-protein-L13	gnl\|CDD\|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	1.80506e-98
NZ_CP029196.1\|WP_150161593.1\|4636900_4638091_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	4.79278e-28
NZ_CP029196.1\|WP_041664126.1\|4633183_4634629_+\|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	3.09284e-66
NZ_CP029196.1\|WP_150161591.1\|4634833_4635721_+\|L,D-transpeptidase-family-protein	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.04437e-19
NZ_CP029196.1\|WP_015035601.1\|4625632_4626145_+\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	2.27683e-74

>NZ_CP029196.1|WP_041664125.1|4632562_4632931_+|holo-ACP-synthase
MIIGVGIDVAEIDRFAASIERTPGLLQRLFVERELLLPSGERRGPASLAVRFAAKEALAKALGAPGGLHWTDAEVYVEGTGQPRLRVRGTVAARAAELGVKHWHVSLSHDAGVASAVVIAEA
>NZ_CP029196.1|WP_015035606.1|4630696_4632544_+|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYVGGQSALDVVVAGLKRLEYRGYDSAGVAVLSDGGLAAAKKAGKLVNLEKELVDRPLAGGSVGIGHTRWATHGGPTDANAHPHLDNAGRVAVVHNGIIENFAALREELTERGHDLLSETDTEVVAHLVAEEFSSAGDLAEAMRLVCRRLDGAFTLVAVHADQPDVVVGARRNSPLVVGVGEGENFLASDVSAFIAHTRSAIELGQDQVVELTRDGVTVTDFDGVPADVRAFHVDWDASAAEKGGYDYFMLKEIAEQPKAVADTLLGRIDGSGRLTLDEVRIPDAVLREADKIVIIACGTAFHAGLIAKYAIEHWTRIPCEVELASEFRYRDPILGQRTLVIAISQSGETMDTLMALRHAREQGAKVLAVCNTNGSTIPRESDAVLYTHAGPEVAVASTKAFLTQLVACYLLALYLGQVRGTKWGDEIHAVVRELARIGDEVERVLETMEPVRALARSLAHKDTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEEDLPVVVVVPSPKGRSVLHDKIVSNIQEIRARGARTIVIAEEGDEAVVPYADHLVRIPATPTLLQPLVSTVPLQVFACELATARGNEVDQPRNLAKSVTVE
>NZ_CP029196.1|WP_150161590.1|4629781_4630657_+|hypothetical-protein
MRPRGGLDGLFHDFARGEPPFRAVWNSKRNSEPVQMRTSMRSAVVAATAVSLALLVTACGGGEKGGDKGDKGGTGAPSASATTSAPAAKALSAAELDKLIVETADLKGHQVTKAGSGDVVPAAQVTADKAACAPIAHAMSFISPGSPAASAQRKVMQEPKKDASASPEDALLGGLSAMVTAVTLGSYDGQGAQEAFASVKKAGTECADGFQVVHLKEKTKVAKVAPEAVTAGEEAVAFTVTSEMEGEPFVSKLVVFRKGNTLASFSTISLVPGGVKALPQAVVDAQAAKLG
>NZ_CP029196.1|WP_015035604.1|4628721_4629690_-|type-I-pantothenate-kinase
MITSPPRSANGTTPYVDLTRAEWSALRDKTPLPLTADEVERLRGLGDVIDLDEVRDIYLPLSRLLNLYVQATSGLRGALNTFLGESAEQRGTPFVIGVAGSVAVGKSTVSRLLQALLARWPEHPRVELVTTDAFLYPMEELKERGLMSRKGFPESYDRRALTRFVADVKAGKEEVTAPVYSHLIYDRVPGERLVVRRPDILIVEGLNVLQPALPGKDGRTRVGLADYFDFSVYVDARPEDIERWYLNRFRKLRDTAFQDPSSYFRRWTQVSEEEAYDYARTMWRTINKVNLLENVAPTRGRATLVVRKGPDHKVQKLSLRKL
>NZ_CP029196.1|WP_150161589.1|4627728_4628679_-|DUF389-domain-containing-protein
MLHLRMIVPPDRTDAAVTLIESTVGTTHLVVLPGAARDPAGDVVMCDTARESADELLHGLRDMRIDQDGSIAVESIDLSMSTRADAAEEEAPGEGADAVIWEQLAEATHEESTLSFTYLSFMGLATMIAACGVVLDNAILIVGAMAVGPEFGPLAGVSTAIVQRAPRLAARSLTALLIGFASAILATTLFSLVMDWMNQFSEDMLDAARPQTSFIWQPDLFSFVVAILAGAAGTLSLTSSKSGALVGVAISVTTVPAAANAAVALSYGEVGQMWGSIEQLLLNLLGIMLAGTATLFLQQRLWRTQRGRLKRRLRRG
>NZ_CP029196.1|WP_150161588.1|4626258_4627617_+|phosphoglucosamine-mutase
MGRLFGTDGVRGVANADLTAELALGLSVAAAHVLAEAGTFEGHRPTAVVGRDPRASGEFLEAAVVAGLASAGVDVLRVGVLPTPAVAHLTGVLGADLGVMLSASHNAMPDNGIKFFARGGHKLADELEDKIEAVYEEHRTGAPWERPTGAGVGRVRDYDEGFDTYVAHLIAVLPNRLDGLKVVLDEAHGAAARVSPEAFARAGATVVTIGAEPDGLNINDGCGSTHLDLLKAAVVEHGADLGIAHDGDADRCLAVDAAGNEVDGDQILAVLALAMREAGRLRGDTVVATVMSNLGFKLAMEREGLTLVQTAVGDRYVLESMKENGFALGGEQSGHVIVLDHATTGDGTLTGLMLAARVAATGKSLADLAGVMERLPQILINVPDVDKSRVKTSGDLAAAVTAAEQELGSTGRVLLRPSGTEPLVRVMVEAADIEQARAVAQRLADVVKSTLG
>NZ_CP029196.1|WP_015035601.1|4625632_4626145_+|30S-ribosomal-protein-S9
MAETTPETPVDEFEGVEEYTTETELVEGEYTSESLASRFGDPQPAAGLGRRKNAIARVRIVPGTGKWKINGRTLEDYFPNKVHQQEVNEPFKVLELDNRYDVIARIAGGGVSGQAGALRLGVARALNEADVENNRPALKKAGFLSRDDRAVERKKAGLKKARKAPQYSKR
>NZ_CP029196.1|WP_015035600.1|4625144_4625588_+|50S-ribosomal-protein-L13
MRTYSPKPGDVTRQWHIIDAQDVVLGRLATTAANLLRGKHKPVYAPHMDMGDFVIIINADKVHLSGNKKTQKLAYRHSGFPGGLRSVRYDELLDKNPEKAVEKAIKGMIPKNTLGRQMLSKLKVYAGENHPHAAQQPVPFEITQVAQ
>NZ_CP029196.1|WP_150161587.1|4623240_4624872_+|ATP-binding-cassette-domain-containing-protein
MHRMGHVEAAHLEYYLPDGRVLLGDASFRVGEGAVVALVGANGAGKTTLLRLISGELQPHGGSVTVSGGLGVMPQFVGSVRDESTVRDLLVSVAQPRIREAAKAVDEAEHLIMTVDDEAAQMKYAQALSDWAEVQGYEAETLWDICTMAALGVPYEKAQFREVRTLSGGEQKRLVLESLLRGSDEVLLLDEPDNYLDVPGKRWLEERLRETRKTVLFISHDRELLSRGAQKIVAVEPGPAGSDVWVHGGGFDTFHEARRERFARFEELKRRWEEKHAQLKKLVVNLRQAAAVSHEMASRYAAAQTRLRKFEEAGPPPEPPREQDIKMRLRGGRTGVRAVTCENLELTGLMKPFSLEIFYGERVAVLGSNGSGKSHFLRLLAGDPSVAHTGDWKLGARVVPGHFAQTHAHPELTGRPLVDILWTEHAKDRGAAMSMLRRYELERQGDQAFDKLSGGQQARFQILLLELAGTTALLLDEPTDNLDLESAEALQDGLESYDGTVLAVTHDRWFAKSFDRYLVFGSDGVVRETTEPVWDERRVERAR
>NZ_CP029196.1|WP_150161586.1|4622182_4623193_-|hypothetical-protein
MSFGGPQWPQEPQQGGQQGYGQQPQPGYGQQQPQGYGQQPGYGQQPGGFPGAPGQGPGPGPGPDPFPGAQGGSTPDWGALADASASRHRRKRWLMIGGGTVAALVVGAIVATAVVANGKKNDEATTGGVPTGAVSPTAAPTPEPTFSSVAPPPPPNPKDYISDPKKDKAPLSAEGLFPGKKLTMNKRVYTKGATSATTNCAAVTQGGLGAVLTKNGCQRVLRATYVKDGVAITVGVAVFPSEAAALKAKGQATGGVAPLTGAGVHDFCHATVCLRRANSVGRYAYFTQAGFADGKKVTTADKPVFQTSDDLGTFTFNQIYARGRAQASAAAGAPGE
>NZ_CP029196.1|WP_041664126.1|4633183_4634629_+|bifunctional-ADP-dependent-NAD(P)H-hydrate-dehydratase/NAD(P)H-hydrate-epimerase
MRTAHRVETVRAAEAALMTRLPEGALMQRAAAGLAAACFSLLGKGRVYGARVVLLVGSGDNGGDALYAGARLARRGAGVTAVLLGDRAHEGGLAALRAAGGRVEADDPFAPLATADLVLDGITGIGGRGGLRPDAVPVARAARGSDAVVVAVDLPSGVDADTGEVTGEALRADVTVTFGTYKPGLLVDPARSYAGALRLVDIGLGDELPGVPDLEALQHQDVARLLPVPGAESDKYRRGVVGVVAGSARYPGAAVLAVEGALRGGAGAVRYVGGAADAVIAAHPETLVHPGPPDRAGRVQAWVVGPGLGDEPGVAEVLASDVPVLVDADGLRGLDPALVRARSAPTVLTPHAGEAAALLDATREEVEAGRLAAVRELAGRYGATVLLKGSTTLVCGAGAAGAVRVNPTGTGWLATAGSGDVLSGLAGSLLAAGLRPVDAASCAAYLHGLAARRASEGRGPVTAGEVAGTLGEAWRDVRAGE
>NZ_CP029196.1|WP_150161591.1|4634833_4635721_+|L,D-transpeptidase-family-protein
MGGWVIRSRSRVVSLFVLPGVLLGVLLVPAVGGPAVADAPEPGDVLVPGVVGGGRAEYPMDTPDQVLPPLQPEGEVPVPVPVPEEDVDELVEYMPRSAVAAACTASTGTHQRQVERLLKLRVDGKQSAADCRAIRAFQVREKIKPANGYAGPVTWARAELLAARKDLDPKRRCPVKKYAVACVDLDRQLMWVRKGSKVTFPVVNIRSGRPGYATRTGWHSIYWRHKDHWSSIYNTPMPYSQFFDGGQAFHAVYGQLATPTGSRGCVNLSYAHARKLWDVLRKGDRVYIWGKRPGS
>NZ_CP029196.1|WP_150161592.1|4635741_4636890_+|alanine-racemase
MTETPPPRRARAEIDLGALRANVRTLRARVAPHVQIMAVVKADAYGHGAVRCARAALDAGADWLGTATPHEALALRAAGITDVPVMCWLWTPGDPWDQGIEAGLDMSVSGMWALEEVVRAARATGGVARVQLKADTGLGRNGCQPADWPELVGEALKAEAEGLVEVTGLWSHFACADEPHHPSIAAQLDVFRSMLDHAEKAGVRPEVRHIANSPATLTLPEAHFDLVRPGIAMYGVSPSPELGTSAELGLRPVMSLKASVALVKRVPAGHGVSYGHHYVTDAETTLGLVPLGYADGVPRHASGRGPVLVDGTVRTVAGRVAMDQFVVDLGGDVPAPGTEAVLFGAGDLGEPTAEDWAVAADTIAYEIVTRIGARVPRVYLGE
>NZ_CP029196.1|WP_150161593.1|4636900_4638091_+|alpha/beta-fold-hydrolase
MGESSSTGTWRRAGFAGAAIGVLAAGAAAGVAVERLTVGRSVRQKARLALDATGPYGGLRGTPGRALADDSTVLYYEVDEVEDDAPPARRRRLFGRKEPAPVTVVFSHGYCLNQDSWHFQRAALRGLVRTVHWDQRSHGRSGLGVAQSGPDGVPVTIDQLGRDLKAVLDVAAPEGPLVLVGHSMGGMTIMALAERYPEFVRDRVVGVAFVGTSAGKLGEVSYGLPIAGVNAVRRVLPGVLRALGSQAELVERGRRATADLFAGLIKKYSFASRDVDPAVARFAERMIESTPIDVVAAFYPAFAEHDKAAALPVLQELPVLALAGDHDLVTPSSHTEAIADLLPDAELVIVPDGGHLVMLEHPEVVTDRLADLLVRAGAVPEATAATVAVRPETGNG
>NZ_CP029196.1|WP_150161594.1|4638101_4638602_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MEAAHPPVSGATLSVDSPEQMQELGRRLAKILRPGDLVMLTGELGAGKTTLTRGLGEGLGVRGAVTSPTFVIARVHPSLVGGPALVHVDAYRLGGGLDEMEDLDLDVSLPESVVVVEWGDGKVEELTDDRLHLLIHRVTGDTDDDRRTVVLRGIGTRWADEDLGVL
>NZ_CP029196.1|WP_150163682.1|4638946_4639489_-|hypothetical-protein
MAGLTAAAVAAVGFLAYQASASAPADLSVKPPTSGTAAPTTSPTGGPKKPAANPLAVPAASGTGERVVYALGDRRVWLVDARNKATRTFSVMPSTVHPTPGAYTVTSRSGSVRGSDGVQIEHVVRFATAQDVAIGFSAAVDGTTPSPDPSKKTGGIRMKRADGDALWTFAVIGAKVVVVP
>NZ_CP029196.1|WP_015035615.1|4639609_4640266_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MLLLAMDTATPAVTVALHDGEAVVASTSQVDARRHGELLLPAVDRVLKEAGRTLDAVTGIVVGVGPGPYTGLRVGLVTAAAFSSALGVPVHGLCTLDGLAYASGIDEPFAVATDARRKEVYWARYEDSRTRVTDAAVDRPAEIAERLAGLPVVGAGARLYPEAFPDARDPEHQSAAGLAALAAEKLAAGGEGFLDPLPMYLRRPDAQVPKNYKVVTPK
>NZ_CP029196.1|WP_041664127.1|4640289_4640760_+|ribosomal-protein-alanine-N-acetyltransferase
MRWWDIAPVLALEDELFPEDAWSAGMFWSELAHARGPRATRRYIVAENGEGRLVGYAGLAAAGGLGDVQTIAVARDQWGTGLGARLLTDLLQHATAFECEEVLLEVRVDNTRAQKLYERFGFEPIGFRRGYYQPGNVDALVMRLTVQGTETDSDGC
>NZ_CP029196.1|WP_015035617.1|4640749_4641868_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MAADEPLVLGIETSCDETGVGIVHGTTLLADAVASSVDTHARFGGVVPEIASRAHLEAMVPTIERALKTAGISAKDLDGIAVTAGPGLAGALLVGVSAAKAYAYALGKPLYGVNHLASHICVDQLEHGKLPEPTMALLVSGGHSSLLLSSDITSDVRPMGATIDDAAGEAFDKIARVLDLGFPGGPVIDRLAKEGDPAAIAFPRGLSGSRDPAYDFSFSGLKTAVARWIEAKRAAGEDVPVRDVAASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVAANSRLRALAQERCERAGIRLRVPRPGLCTDNGAMVAALGSEMVARNRPASDLELSADSSLPVTDPHVPGAAHGHGHSHDHDHVHEVSKENLYS
>NZ_CP029196.1|WP_150161595.1|4641864_4642119_+|hypothetical-protein
MRLTLMWEARAAQGRGAELLEWARARVLPREPVRREIFRAPQDRVLVLTWWEAETFDAELPELPEPDAELITRPVHRWRFESIE

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Crispr_ID: NZ_CP029196_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_14

4670754-4670862

Orphan

Consensus_repeat	Method
GGTGCGACTGGTGCGGCCGGTTCCG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP029196_14

>merge|NZ_CP029196|14|4670754-4670862|CRISPRCasFinder
GGTGCGACTGGTGCGACTGGTGCGACTGGTGCGGCCGGTTCCGGGGAGGCCGGTGCGACCGGTGCGGCCGGTTCCGCGGAGGCCGGTGCGACCGGTGCGGCCGGTTCCG

>NZ_CP029196|14|10|4670754-4670862|CRISPRCasFinder
GGTGCGACTGGTGCGACTGGTGCGA	CTGGTGCGGCCGGTTCC
GGGGAGGCCGGTGCGACCGGTGCGG	CCGGTTCCGCGGAGGCC
GGTGCGACCGGTGCGGCCGGTTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150161605.1\|4673219_4676270_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP029196.1\|WP_015035652.1\|4683297_4684899_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
NZ_CP029196.1\|WP_150161608.1\|4682676_4682970_-\|chorismate-mutase	unknown	unknown	gnl\|CDD\|236117
NZ_CP029196.1\|WP_015035645.1\|4668538_4670245_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NZ_CP029196.1\|WP_150163683.1\|4671155_4673060_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP029196.1\|WP_150161603.1\|4660725_4661631_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP029196.1\|WP_150161604.1\|4667034_4668276_-\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223749
NZ_CP029196.1\|WP_150161602.1\|4659970_4660645_-\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225167
NZ_CP029196.1\|WP_106433874.1\|4663414_4663987_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|236607
NZ_CP029196.1\|WP_015035642.1\|4664210_4665713_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
NZ_CP029196.1\|WP_150161607.1\|4680089_4681922_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|225186
NZ_CP029196.1\|WP_150161609.1\|4685010_4685799_+\|class-II-aldolase/adducin-family-protein	unknown	unknown	gnl\|CDD\|235743
NZ_CP029196.1\|WP_150161606.1\|4676406_4678212_+\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP029196.1\|WP_015035643.1\|4665819_4666944_+\|GuaB3-family-IMP-dehydrogenase-related-protein	unknown	unknown	gnl\|CDD\|236322
NZ_CP029196.1\|WP_015035649.1\|4678404_4680051_+\|succinate-semialdehyde-dehydrogenase-(NADP(+))	unknown	unknown	gnl\|CDD\|236501
NZ_CP029196.1\|WP_003948568.1\|4662529_4663141_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP029196.1\|WP_150161611.1\|4687313_4687994_+\|DoxX-family-membrane-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP029196.1\|WP_150161610.1\|4685967_4687209_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_015035637.1\|4659146_4659920_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP029196.1\|WP_015035640.1\|4661704_4662097_-\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150161605.1\|4673219_4676270_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.14295e-20
NZ_CP029196.1\|WP_015035652.1\|4683297_4684899_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
NZ_CP029196.1\|WP_150161608.1\|4682676_4682970_-\|chorismate-mutase	gnl\|CDD\|236117	PRK07857, PRK07857, chorismate mutase.	8.33265e-35
NZ_CP029196.1\|WP_015035645.1\|4668538_4670245_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	3.17952e-163
NZ_CP029196.1\|WP_150163683.1\|4671155_4673060_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.95311e-103
NZ_CP029196.1\|WP_150161603.1\|4660725_4661631_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.48226e-57
NZ_CP029196.1\|WP_150161604.1\|4667034_4668276_-\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	1.61656e-132
NZ_CP029196.1\|WP_150161602.1\|4659970_4660645_-\|MOSC-domain-containing-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	4.51687e-59
NZ_CP029196.1\|WP_106433874.1\|4663414_4663987_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|236607	PRK09648, PRK09648, RNA polymerase sigma factor ShbA.	6.31551e-91
NZ_CP029196.1\|WP_015035642.1\|4664210_4665713_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
NZ_CP029196.1\|WP_150161607.1\|4680089_4681922_+\|NAD(P)-binding-protein	gnl\|CDD\|225186	COG2303, BetA, Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism].	5.0946e-50
NZ_CP029196.1\|WP_150161609.1\|4685010_4685799_+\|class-II-aldolase/adducin-family-protein	gnl\|CDD\|235743	PRK06208, PRK06208, class II aldolase/adducin family protein.	1.23908e-151
NZ_CP029196.1\|WP_150161606.1\|4676406_4678212_+\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.56058e-105
NZ_CP029196.1\|WP_015035643.1\|4665819_4666944_+\|GuaB3-family-IMP-dehydrogenase-related-protein	gnl\|CDD\|236322	PRK08649, PRK08649, GuaB3 family IMP dehydrogenase-related protein.	0
NZ_CP029196.1\|WP_015035649.1\|4678404_4680051_+\|succinate-semialdehyde-dehydrogenase-(NADP(+))	gnl\|CDD\|236501	PRK09407, gabD2, succinic semialdehyde dehydrogenase; Reviewed.	0
NZ_CP029196.1\|WP_003948568.1\|4662529_4663141_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.73082e-50
NZ_CP029196.1\|WP_150161611.1\|4687313_4687994_+\|DoxX-family-membrane-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	2.72767e-09
NZ_CP029196.1\|WP_015035637.1\|4659146_4659920_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	4.92024e-83
NZ_CP029196.1\|WP_015035640.1\|4661704_4662097_-\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	8.00343e-28

>NZ_CP029196.1|WP_015035645.1|4668538_4670245_+|glycerol-3-phosphate-dehydrogenase/oxidase
MRTATLGPAERIEALAGMAERELDVLVVGAGVVGAGTALDAVTRGLSTGIVEARDWASGTSSRSSKLIHGGLRYLEMLDFALVREALKERGLLLERLAPHLVKPVPFLYPLQHKGWERFYAGSGVALYDAMSLSSGHGRGLPVHRHLSRRGALRVAPCLRKDALVGALQYYDAQMDDARFVTTLVRTAASYGALAASRARVTGFLREGARVVGARVQDVEAGAAYEIRAKQIVNATGVWTDDTQALIGERGQFHVRASKGIHLVVPKDRIHSTTGLILRTEKSVLFVIPWGRHWIVGTTDTEWDLDKAHPAASSADIDYLLEHVNTVLATPLTRDDVEGVYAGLRPLLAGESDATSKLSREHTVAHPVPGLVVVAGGKYTTYRVMAKDAVDEAVHGLDQRVAPCVTEDTPLLGAEGYRALWNARARIAARTGLHVVRVEHLLNRYGSLTEQILALIAEDPTLGEPLEAADDYLRAEIVYAASHEGARHLDDVLTRRTRISIETFDRGTRSARVCAELMAPVLGWDEHQIDKEVEHYEKRVEAERESQRQPDDLTADAARLGAPDIVPI
>NZ_CP029196.1|WP_150161604.1|4667034_4668276_-|nucleotide-sugar-dehydrogenase
MPADLAVIGLGHHGLPLAQAATAAGIDTIGYDTDPHPVAELAAGRSPVDGSLTVPEIRRMLSGGFRPTANPAELGRVRTAVLCAPTPLGPDRALDLTAVTDAARALAARLRPHTTVLLESPVPPGTTEGLLRDLLEAGSGLRAGRDFHLAYSPGRLDPGSRTHGFAGTPKVIGGLTPACTESAAAFYGRLTDKVVRARGPREAETVKLLETNFRHVNIALVNEMAVLCHELGVDLWDVIRCAETKPFGFQAFRPGPGVGGHGAPVDTIGAHRPLRLVELAGQVNERMPRYVVQRAAALLNEHGKSARGARILLLGITYKPDLPDRQGSPADEIARRLMDLGAAVSYHDPHVPDWRVRELPVPRADSLYEAAAHADLTILLQHHRTYDLQGLSVKAQLLLDTRGATPAGAAHRL
>NZ_CP029196.1|WP_015035643.1|4665819_4666944_+|GuaB3-family-IMP-dehydrogenase-related-protein
MTEIEIGRGKRGRRAYAFDDIAVVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPQTAIRIGELGGLGVLNLEGLWTRYEDPQPLLDEIAEMDEATATRRLQEIYAAPIKEELIGQRIKEVRDSGVVTAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGASEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGWSGDLPKAIACGADAVMMGSPLARATDAPGKGHHWGMEAVHEDVPRGKLVDLGIVGTTEEILAGPSHIPDGSMNFFGALRRAMATTGYSELKEFQRVEVTVADSQHRR
>NZ_CP029196.1|WP_015035642.1|4664210_4665713_+|IMP-dehydrogenase
MTANVDGVPEKFATLGLTYDDVLLLPGASEVLPNAVDTSSRISRNVRVNIPLLSAAMDKVTESRMAIAMARLGGVGVLHRNLSVEDQVNQVDLVKRSESGMVTDPITVHPEATLAEADALCAKFRISGVPVTSPDGKLLGIVTNRDMAFESDRSRQVREVMTPMPLVTGKVGISGVDAMELLRRHKIEKLPLVDDAGVLKGLITVKDFVKAEKYPNAAKDAEGRLLVGAAVGASPEALERAQALAGAGVDFLVVDTSHGHNSNALSWMAKIKSSVGVDVIGGNVATRDGAQALIDAGVDGIKVGVGPGSICTTRVVAGIGVPQVTAIYEASLAARAAGVPLIGDGGLQYSGDIGKALAAGADTVMLGSLLAGCEESPGELLFINGKQFKSYRGMGSLGAMQSRGQGRSYSKDRYFQAEVASDDKLVPEGVEGQVPYRGPLSNVLHQLVGGLRQTMGYVGAATVAEMESKGRFVRITSAGLKESHPHDIQMTVEAPNYSRK
>NZ_CP029196.1|WP_106433874.1|4663414_4663987_+|sigma-70-family-RNA-polymerase-sigma-factor
MPSGQGEIGALVHRAVDGDAQATHDLLARVHPLALRYCRTRLNRLPGDARHFVEDLAQEVCVAVLMALPRYKDTGRPFEAFVFAIAGHKVADLQRAAMRHPGSTAVPSDEMPERPDDSLGPEERALLSDDAEWAKKLLANLPENQRELLVLRVAVGLTAEETGQMLGMSPGAVRVAQHRALSRLRALAEQ
>NZ_CP029196.1|WP_003948568.1|4662529_4663141_+|response-regulator-transcription-factor
MTSVLVCDDSPLAREALRRAVATVPGVERVTTAANGEEVLRRWGADRSDLILMDVRMPGLGGVETVRRLLSADPGARIIMLTVAEDLDGVALAVAAGARGYLHKDASRAELRATVTQALADPTWRLAPRRLRSAEMGAAPTLTAREIQVLEGMSHGRSNAEIGRELFLSEDTVKTHARRLFKKLGASDRAHAVALGFRWGLVR
>NZ_CP029196.1|WP_015035640.1|4661704_4662097_-|WhiB-family-transcriptional-regulator
MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSARENSAKEVCMRCPVRAECAAHALAVREPYGVWGGLTEDEREELMGRARNRLIAAAPATSSSVASVASVTSMTTSAAAAGRPIVERM
>NZ_CP029196.1|WP_150161603.1|4660725_4661631_+|LysR-family-transcriptional-regulator
MIEARHLRVLRAVAATGSFSAAARELGCTQPAVSQQMKALEASAGTPLLIRAAREMRLTQAGEVLVRHASGILAGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSTLVPTALARLRAAHPGTRVSLVEAEPPRSIEMLREGDCDVALAFRYGAGKAEGQAEWDDLVVRPILADRLVGLVPEGHRLAGAGSVGMAELADESWIAGCPRCRRQLVDVCEEAGFTPRIDFATDDYPAVVGLVGAGLGVAVLPELAIESVRPRGARTVAVEPAVEREIVALTLPDLAQVPAVAATLDELTRAAARA
>NZ_CP029196.1|WP_150161602.1|4659970_4660645_-|MOSC-domain-containing-protein
MTLLSVNVGRAKAVDYTDAASGLTAIDKRPVEGPVRIEAPGAPGVGRSGLAGDTVCDLRFHGGDDRAAYAFAREDLDRWERELGRELANGSFGENLTTRGLDVNGALIGERWRIGEEVVLEVTGGRIPCRTFAGFVEEKGWVKRFTRSEAGPGALLRVIVPGEIRAGDPVTVVHRPDHDITVALLHRAATTERTVLPRTLAAAEWMESGLLALARQYAEKYARA
>NZ_CP029196.1|WP_015035637.1|4659146_4659920_-|SDR-family-NAD(P)-dependent-oxidoreductase
MTTALITGATAGIGAAFARRLAADGHDVVLVARDMKRLREQATELHDRHGVEAEVLSADLADEKGIAAVEARLSDPKQPVDLLVNNAGFGNKGRFLEVSMADELKMLTVHCEAVLRLTSAAAASMKERHRGAVVNVASVAAFVPRGTYGASKAWVVQFTQGAARDLAGSGVRLMALCPGFVRTEFHERAGMGTDNIPGWMWLDADRLVTAALSDLERGKTLSIPDPRYKALMGVVKLAPRGLLGGVSSKAGRKYGPK
>NZ_CP029196.1|WP_150163683.1|4671155_4673060_+|protein-kinase
MLAGRYRLGAVLGRGGMGTVWRAVDETLGRTVAVKELRFPSSIDDDEKRRLITRTLREAKAIARIRNNGAVTVYDVVDEDDRPWIVMELIEGKSLADAVREDGTLTPRRAAEVGLAILDVLRSAHREGILHRDVKPSNVLIAEDGRVVLTDFGIAQVEGDPSITSTGMLVGAPSYISPERARGHKPGPAADMWSLGGLLYAAVEGSPPYDKGSAIATLTAVMTEPVDPPKNAGPELEKVIYGLLAKDPAQRLDDARARVLLMAVLDAPVAAPEASPEVTRVVPLPPRPDRAPAAPTAGREKAPDASADRMRGALNSVRNAAASVKAEPKTPSVPGARTGAGAVPVRGGGRPAPARAPLTDVVPRRTLVIIAAVVVLALLGTILAVSLGGGGDEGNEGKGTGGTASAGSTAGGDGSGSGSGSGGSDGGNGQASGGPGQQGGVQPGDTGSNGATGANGTTGASGGSNGTGGTPSGKPGGGSGAQLPAGYTLVTNARFHFTMALPANFTLRDIPGYSGGGIFSESGGFPRIQVDFNASPKDDAASAWELAKIGVAATSKDYKHIGIKGVSFNGYPTVADWEFERTQQGMRVHVLNRGFKVDAKHGYSLMISCKAEEWNGAECRTLRDTAFATFRPKD
>NZ_CP029196.1|WP_150161605.1|4673219_4676270_+|protein-kinase
MDDYAGRVLADRYRLPLPPADADAYDLAETRAFDTYSGQEVLVRQVPLPEFVDAEVLDGDGGPAGPYGTAGRATRRPAEPVVRRAIEAAQAAAQIPDHPLLDQVFDVFAEAGSLWIVSERIAARPLAALLAERPLNPYRAAEIGADVLTALRALHAHGWVHRNITSRTVLVCDDGRVVLTGLAVGAAEEALCGYAPVPDPERDTHAPAWETPEQEEDGSEQYDSEEYGAEQYGSEEYEAEEYGAEGYASDGYGSGEYAVEEYGSGPYAAAVHGGADGLPDELPGELLEETAEAYDAEEYGPERYGRQEYDPEEAEFQEAESPEYGPPEYGPQEYQAEEYDAQDYGSDEAGGSSPYEDDDPSPYGSGPRPASHGTDSGRSVTPPTADVRAARAGAIAAYRAGARAAARLGETGALPVQRPAPADPPEPPPAPTARAAGAPQWWAQVAEDDEDDDGDDGEPYGGAPQGGPPPRVMLAGNWSDGPHASRDGSVPAGGSPVLPGSGRPALPAGYTAATPDPARLPLQAQPRLEGRELVAVPARADRGPTTRLAAERARQTRIAVVGAVTERWAPEQAGPVHENWRLAPPIGPATDLWALGALLYRAVQGHAPYPEDSAAELVQLVCAEPPAFAEECGPLRPVVESLLRQDPTERPDFEELRGWLRSLVRSAPEPEAGIGVVPLPSFDEARLPIVRRRGELVRRRRGGAAAGRHRHKRGKEPRSAARTEGARGPAPVPADVRDEFLDDFHEEIPQRASRAPRAPRGSRPSSSRFKDPSRSRESPRSLGRTLLVLVFLLLGGAVAYAVLFMPGEGGSPTKPPTEPTPKSSAPTAGQPPRTTAPSTGRPSATTAAPTAPRTTEPGADPSGPALAAGYTARQDPEGFRIGVPNGWRRSPINDSGQVRYTGGDFTMIVVPGRDSVQDNGSDPLEYQNSRERELEPWRASSWSGAEKTRRVDIGTTATATGSYWWLDGTGREVFVRNLALIGGGRYHIVQVIGPYGERDKVSEIYEEATRAFRPGR
>NZ_CP029196.1|WP_150161606.1|4676406_4678212_+|protein-kinase
MEHSQSTGEGLLLAGRYRLGESIGRGGMGKVWRAHDEVLHRVVAVKELTAGRFVAEADRLVLHARTQKEARAAARITHPGVVTVHDVLEHDDRPWIVMQYVDGPSLADAAKEQGTIDPHEAARIGLHVLGALRAAHAAGVLHRDVKPGNVLLARDGRVLITDFGIAAIEGDATITRTGELVGSIDYLAPERVRGGDPGPASDLWSLGATLYTAVEGTSPFRRTSPISTMQAVVAEEPPYPEKAGPLAPVIVALLRKDPDQRPRADEAGRMLLDAMEGRTPDAAQAYVPTQRVAKEDLDPAGDTPIQGHDLLTLGEEADGPGPTGTSRATAPSGTAQWPHPAQGSQSAQGSRSAQGSPTAQGSRSAQGSAQAGSSQGQSSPPTVVPPAVVTPAGGGRGRWRTAVLAAVLAGLVAGGAVFAAMNYAGGGKGDGGRTTATGSTPAPTTQAAKDGLPAGWQRVVDREGFSLAVPKGWKRQTEGDNIDYTPDNGNHRIRISVDPAPDFENPYMHALDLERIVAKRMDYTRVKLGQTTYRDQVRSSLWEFTWMEKRDFPGPRHAIDLMYYADDGTEYAIYMSSPEGSWETTREQFDIVLQHWRAPGD
>NZ_CP029196.1|WP_015035649.1|4678404_4680051_+|succinate-semialdehyde-dehydrogenase-(NADP(+))
MTDSQAPAAPSVPDAPAVPAEATNPVAPVPAGVRTAADVVTPEVVARLTRGVIGSGRTANHTPFTGAKLADLPESTPEDVAEAFTRARGAQAAWAATPVKARAAVLLRFHDLVLQRQSEVLDLIQLETGKARLHAHEEVQAVAVAARHYGRKAPAYLKPRHHTGVVPTLTKVTELRQPRGVVGQIAPWNYPLELSVGDALPAFVSGNAVVMKPDTETALTALWARDLLIEAGLPAEVFQVVLGEGPVVGPEVVKHADYVSFTGSTRTGREVAQGAAARLVGVSLELGGKNAMLVLKDADIEKAAAGAVRACFSSAGQLCISIERLYVHESVAEDFLARFAARTKAMRLGSALAYGADMGSLVGERQLETVSRHVEEAVAKGATLVAGGVARPDIGPLFYEPTILDGVEAPMAVCGEETFGPVVSIYRFRDEDEVVDLANATPYGLNSSVWTKDSRRGHAVAARLRTGTVNINEGYAPAYGSVQSPMGGMKDSGLGRRHGSEGILKYTEAQTVAQQRLMPLAPSFGMDDEKYAAFMSVSLKAMKALRLR
>NZ_CP029196.1|WP_150161607.1|4680089_4681922_+|NAD(P)-binding-protein
MTAVPPTQNQEPADDAYDYDVLVVGSGFGGSVTALRLTEKGYRVGVLEAGRRFTPETLPKNSWDLKNFLWAPALGLYGLQRIHLLGNVMVLAGAGVGGGSLNYANTLYVPPKPFFDDPQWKDITDWQEELRPYYDQAQRMLGVRLNPTTTPSDVHLKAAAQAMGIGDTFHMAPVGVFFGDGRDADGGDGAGTKVKPGTEVADPYFGGAGPSRRACTECGECMTGCRHGAKNTLNENYLHLAEKAGATVHPMTTVVTVTEDSRGGFAVKTLPTDQRRKGKGRTFTARRVVIAAGTYGTQTLLHRMKDSGLLPRISRRLGELTRTNSEGLVGAQTTDRRYRKRHGKDRVDFTKGVAITSSVHPDANTHIEPVRYGKGSNSMGGMTVLQVPYGAHRVRNWLLNLVKHPTLAARSLSNWRWSERTIIGLVMQSLDNSLTTYRKPGGLGKGLLTARQGHGAPNPVQIPEATRAATLLAEEINGFAGSNIGELMGTPLTAHFLGGCPIGADAESGVIDPYHRLYGHPGISVVDGAAVSANLGVNPSLTITAQAERAMSFWPNKGEEDIRPRQGEAYVRLSAVEPKCPAVPAEAFGALRLPFLGIPAVPPKKLRDGS
>NZ_CP029196.1|WP_150161608.1|4682676_4682970_-|chorismate-mutase
MTTHTATTEQTGARTDEAAALIGDSRERIDALDDRIIGLIQERMAVSAVIQEARISSGGRRVNLTREMEVLGHYRDALGKPGTALAMTMLELCRGRI
>NZ_CP029196.1|WP_015035652.1|4683297_4684899_+|glutamine-hydrolyzing-GMP-synthase
MSSATPAAAPDVTNPDVVLVVDFGAQYAQLIARRVREARVYSEIVPSTMPVAEMLAKNPKAIILSGGPSSVYAEGAPRLDRALFEAGVPVFGMCYGFQLMATTLGGTVDNTGAREYGRTPLHVSKAGSTLFEGTPVEQSVWMSHGDACSAAPEGFTVTASTDVVPVAAFENDEKKLYGVQYHPEVLHSTHGQQILEHFLYRGAGIEPSWTTGNVIEEQVAAIRAQVGTKRAVCGLSGGVDSAVAAALVQKAIGSQLTCVYVDHGLMRKGETEQVEKDFVASTGVNLKVVDAQERFLTALAGVSDPETKRKIIGREFIRVFEQAQAEIVAESAGTGEDVAFLVQGTLYPDIVESGGGTGTANIKSHHNVGGLPEDLEFELVEPLRQLFKDEVRMVGQELGLPEEIVQRQPFPGPGLGIRIVGEVTKERLDLLREADAIAREELTAAGLDREIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWSRLPYEVLAKISTRITNEVADVNRVVLDVTSKPPGTIEWE
>NZ_CP029196.1|WP_150161609.1|4685010_4685799_+|class-II-aldolase/adducin-family-protein
MSVIPDPVPVDRLHFAMPPVHATAEEERTHRKQRLAGALRLFGRFGYEEGVSGHISARDPEHPDCFWVNPFGAPFEEITASDLILVNGDGQVVRGGQHVNQAAFTVHAQVHRARPDAVAVAHTHSVHGRALAALGELLDPLTQEACAFYQDHALYDAYTGVTVDPEEGRRIAVALGPFKGIVLRNHGLLTVGTSVDAAAWWFIAMERSAQVQLAARAAGKPVLIDHREALATREQLGSDLVAWINYQPLWRRISRTDPELLS
>NZ_CP029196.1|WP_150161610.1|4685967_4687209_+|hypothetical-protein
MSTVAVQEARQYGEHATACAGCAHCGQAGHRRAVAAFLARRDELASGRGVPVAVAHSPVAARQWVSDELAQSARAVAVHGREAGVAWLDRVRRGGLGAVWGAVLALLLGQALTAVDGGWTAARTAGLCTAVVLAALLSAAAHAHRSRGGLLAPLIGEDNRLSTTRAVAAAWLLLLGYTLLFLAFLSPGAAAFGLARGAGLLTVLALVSAVTVTARLVVAGGIASRRLQKVRADRPRAADLVCDDSGRASLADVQYLLVSGSVLALAAVGLARDPARLPEVPWSLVLLLGVSSAWHLAAKCTEGVRPTIHSVVRSREAGDLDAPIRTGDDIEIRGCGFVPPGAGAPDPLTRLVVRIGPVHAHVPLVPVPGGFANPTDAALTVPLPADVEPGRVEVSVVTAAGVETNRITIDVVD
>NZ_CP029196.1|WP_150161611.1|4687313_4687994_+|DoxX-family-membrane-protein
MTGHADRADNAADGTGTGGRDGSGGPAGRDGGGGPDGSGGPGGAAAARGGSGGSDRSGRSGGSGGSGRFGRFDRWKAVASRYSLLPLRIFLGVTFIYAGLDKLTDSAFFADTGSGSIGETMRGVRDTSAIPALVDLALNNPTGFGYAIAFGELAVGIGTLLGLFARLAALGGALISLSLWLTVSWQVNPYYLGNDLAYLMAWLPLVLAGASVLSVDRLLAERRRMP

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Crispr_ID: NZ_CP029196_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_15

5016095-5016269

Orphan

Consensus_repeat	Method
GAGCCGACCGCGAATCGGCTGTGATCGTTTGCGATCCGGCCGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_15

>merge|NZ_CP029196|15|5016095-5016269|CRISPRCasFinder
GAACCGGCCGCGAATGCGCCGCGATCGGTTGCGTTCCGACCGTGAGCCGACCGCGAATCGGCTGTGATCGTTTGCGATCCGGCCGCGATCCGGCCGCGATCCGGCCGCGAGCCGGCCGCGAGCCGGCCGCGAGCCGACCGCGAATCGGCTGTGATCGTTTGCGATCCGGCCGCGA

>NZ_CP029196|15|11|5016095-5016269|CRISPRCasFinder
GAACCGGCCGCGAATGCGCCGCGATCGGTTGCGTTCCGACCGTGA	GCCGACCGCGAATCGGCTGTGATCGTTTGCGATCCGGCCGCGATCCGGCCGCGATCCGGCCGCGAGCCGGCCGCGAGCCGGCCGC
GAGCCGACCGCGAATCGGCTGTGATCGTTTGCGATCCGGCCGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150161787.1\|5017641_5018736_+\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|237264
NZ_CP029196.1\|WP_015035973.1\|5018820_5019570_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|224527
NZ_CP029196.1\|WP_015035978.1\|5023030_5023696_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP029196.1\|WP_009997451.1\|5022697_5022865_+\|DUF3117-domain-containing-protein	unknown	unknown	gnl\|CDD\|371461
NZ_CP029196.1\|WP_015035977.1\|5021581_5022385_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|236163
NZ_CP029196.1\|WP_145953716.1\|5008649_5008967_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161786.1\|5016619_5017612_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161788.1\|5019675_5020536_-\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|273657
NZ_CP029196.1\|WP_150161790.1\|5020965_5021556_+\|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl\|CDD\|377025
NZ_CP029196.1\|WP_150161789.1\|5020639_5020969_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161781.1\|5007177_5008068_+\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	unknown	unknown	gnl\|CDD\|274584
NZ_CP029196.1\|WP_150161784.1\|5014126_5015221_+\|succinyldiaminopimelate-transaminase	unknown	unknown	gnl\|CDD\|236119
NZ_CP029196.1\|WP_150163704.1\|5009436_5010975_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029196.1\|WP_150161785.1\|5015295_5015757_-\|ATP-binding-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_015035968.1\|5013697_5014018_+\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|224069
NZ_CP029196.1\|WP_015035963.1\|5010991_5011216_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150163703.1\|5008211_5008526_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161783.1\|5012583_5013585_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP029196.1\|WP_078508732.1\|5023837_5024599_+\|RNA-polymerase-sigma-factor-SigE	unknown	unknown	gnl\|CDD\|236606
NZ_CP029196.1\|WP_150161782.1\|5011678_5012587_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|372582

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015035973.1\|5018820_5019570_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	7.80718e-55
NZ_CP029196.1\|WP_015035978.1\|5023030_5023696_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	4.45596e-52
NZ_CP029196.1\|WP_015035977.1\|5021581_5022385_-\|enoyl-CoA-hydratase	gnl\|CDD\|236163	PRK08140, PRK08140, enoyl-CoA hydratase; Provisional.	2.93121e-70
NZ_CP029196.1\|WP_078508732.1\|5023837_5024599_+\|RNA-polymerase-sigma-factor-SigE	gnl\|CDD\|236606	PRK09647, PRK09647, RNA polymerase sigma factor SigE; Reviewed.	7.0151e-122
NZ_CP029196.1\|WP_150161788.1\|5019675_5020536_-\|dihydropteroate-synthase	gnl\|CDD\|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	1.99269e-92
NZ_CP029196.1\|WP_150161790.1\|5020965_5021556_+\|DNA-3-methyladenine-glycosylase-I	gnl\|CDD\|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	9.469e-101
NZ_CP029196.1\|WP_009997451.1\|5022697_5022865_+\|DUF3117-domain-containing-protein	gnl\|CDD\|371461	pfam11314, DUF3117, Protein of unknown function (DUF3117). This family of proteins with unknown function appears to be restricted to Actinobacteria.	8.29864e-23
NZ_CP029196.1\|WP_150161781.1\|5007177_5008068_+\|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	gnl\|CDD\|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	2.37791e-130
NZ_CP029196.1\|WP_150161784.1\|5014126_5015221_+\|succinyldiaminopimelate-transaminase	gnl\|CDD\|236119	PRK07865, PRK07865, N-succinyldiaminopimelate aminotransferase; Reviewed.	0
NZ_CP029196.1\|WP_150163704.1\|5009436_5010975_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.56882e-09
NZ_CP029196.1\|WP_015035968.1\|5013697_5014018_+\|ferredoxin-family-protein	gnl\|CDD\|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	3.6265e-11
NZ_CP029196.1\|WP_150161782.1\|5011678_5012587_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|372582	pfam13369, Transglut_core2, Transglutaminase-like superfamily.	1.46368e-36
NZ_CP029196.1\|WP_150161783.1\|5012583_5013585_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.47718e-09
NZ_CP029196.1\|WP_150161787.1\|5017641_5018736_+\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|237264	PRK13007, PRK13007, succinyl-diaminopimelate desuccinylase; Reviewed.	0

>NZ_CP029196.1|WP_150161785.1|5015295_5015757_-|ATP-binding-protein
MSLPLTRRIARAALLIAAGAAPVVGAAGSASALDHNIAPTGSLGGLTALDAAGAGTAVDSASQTATGVVGATGSQAVGTAVPAAGKSVGAAGRTATPAVQKVAGDTAGSAGEVVGKTAGAAAESAEGPTGGALGGGVGNLPTGQTLGGLPLGG
>NZ_CP029196.1|WP_150161784.1|5014126_5015221_+|succinyldiaminopimelate-transaminase
MSAVSSRLPVFPWDKLEPYKKTALAHPDGIVDLSVGTPVDPVPALIRQALVAAADSPGYPTVWGTKELRDALTGWCERRLGAVGFAHENVLPVVGSKELVAWLPTQLGLGAGDKVAYPRLAYPTYEVGARLCGAEPVVYDDPTELDPSGLKLLWLNSPSNPTGKVLAKDELTRIVAWAREHGVLVFSDECYLELGWEADPVSVLHPDVCGGTYEGIVAVHSLSKRSNLAGYRAAFIAGDAAVLGELLQIRKHGGMMTAAPVQAATVAALGDDAHVAEQRARYAARRAALRAALEAHGFRIEHSEASLYLWATRDEPCWDTVAYLAELGILVAPGDFYGEVGATFVRVAFTATDERVEAAVKRLG
>NZ_CP029196.1|WP_015035968.1|5013697_5014018_+|ferredoxin-family-protein
MTYVIAQPCVDVKDKACIEECPVDCIYEGKRSLYIHPDECVDCGACEPVCPVEAIFYEDDTPEEWKDYYKANVEFFDELGSPGGASKLGEIERDHPFIAALPPQNG
>NZ_CP029196.1|WP_150161783.1|5012583_5013585_-|GNAT-family-N-acetyltransferase
MEIIGGGRLEVRITGADVGKRVSVRYVTESAAAGGGFTDAVGVLTSWDNSVLLITRKSGESVRIAESTLVAGKVVPAAPARRRGPAATFPELARVTARAWQPVESEALGEWTLRAADGFTRRANSALPLGDPGLPVADALRRVRAWYEDRKLPAYVQTATGAEGAQELLSAELDRHGWRREVSAEVRIAALAPIGDLDADVSAVRLSRTVDESWLRRYQRFGEPGPAVRSVLTSGPSVWFASVAGTGEVPAAIGRCVVDGRWAGFMAVEVDPDQRRRGLATSVMTALARTALDEGASAAWLQVEADNDGARALYDGMGFAPHHHYHHYRWAEA
>NZ_CP029196.1|WP_150161782.1|5011678_5012587_-|tetratricopeptide-repeat-protein
MTEDVPPPPDEPEGPADGPFEAEGAFEAAAPPDWRREFAEEARSERPDLARLCLLIGAVADPTVTRHTLNEAEIELDRLAGLVPYATRTTGDWTTALAGLLGHREGFVGVPADYQRLESSLLHEVLRRRRGLPILLSVVWMEVARRAGAPVYGLGLPGHFVVGFGDPADLDLADPFAGGRAMTGTDAELLVTSATGEALDRSMLRPAEPGAIVLRVLNNIRAWAAPRPERSDVALWAVELSLLLPSHPARLRYERAELLVQRGDFLTGAAEMEAYAQVMDAVDPDAATAIRRRAQAARARLN
>NZ_CP029196.1|WP_015035963.1|5010991_5011216_-|hypothetical-protein
MHTPHGPGAFVAHTGTDVYGPGKVLAVDGAHRRVRFTRFVATVRAEDLRPASPAEKREIQDWLRAKRQRYGGDW
>NZ_CP029196.1|WP_150163704.1|5009436_5010975_+|hypothetical-protein
MYDGTPSGGTPLYDGTQTSGTPMYDGTPAAGTPRYRGPAGEPTGPTTGPVMGTASLGGPGASAGQGPGQGPGRGPGAGPGSPFAGGTPGGVPGGSPAGGPAGGPGGAPRLSDDTAILTPQAPAPTRGRKGGPSAPGGAHAGQPADGSGHISGDTLTSGIPVVPPSAARPGPAAPRGEEQAAPAAAPRPAPAPNRAAPAKKGRSKLVLVAAGVFGLVGIAYGAGLLLNHSDVPKGTTVLGVDIGGGTKEEGVNKLEAALGKRAGTPLQLGIGGKKVQLAPDKAGLALDSQETVRAAAGSDYNPVSVIGSLFGGERVAKPVFPVDEEKLAVALADLAGTSASATEGTILFAPNKVTPVEGKPGKGLDVQRSMISVRDAFRAQVETGQSKLVELPVTTRRPSVSKAELDRAMKEFATPAMSDRITIKAGGKEIQFGPARSLPQIISMKAVDGRLVAVYDTKAIERLLDGAFKGIMITKSDGSKHEVSADDVAAVMGEALLGKTKAERTKTIDPKG
>NZ_CP029196.1|WP_145953716.1|5008649_5008967_-|hypothetical-protein
MTVVRTTTGGIGREPGMLIRMRVVRVVSVLGSSGGAGAAAVSSGASCVGWSDGYWRDPYGGVPEGYAAPPRPWAPEDELSVSRPVSRLKAGSPGWLHRPLLLRLV
>NZ_CP029196.1|WP_150163703.1|5008211_5008526_+|hypothetical-protein
MLVLGLLVGTAGALVQAAWLPGGLILALLGTAGLFYGGMRATGNQIGVAAGGGGWLIAVILLSFGRPEGDGAFGGGVGELLFLFGGMAIAVMCTTLARLPRPTP
>NZ_CP029196.1|WP_150161781.1|5007177_5008068_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase
MSDLPARRLLLVHAHPDDESINNGATMARYAAEGALVTLVTCTLGEEGEVIPPELAHLAPDREDRLGPHRVGELAAAMAELGVTDHRFLGGPGRFRDSGMMGAEQNKRDNAFWNTDVDTAAPYLVEVIRETRPQVLVTYDPDGGYGHPDHIQAHRVATRAAELAADPAYRPDLGPAHTIDKIYWNRVPRPVAEAGFARLRAEGSAFPAVAAIDDVPGVVDEDRITTEIAAGPELAARKSAAMAAHATQVAVDGPFFALSNDLGQPIFTTEYYELVKGTPGAPAGVRETDLFAGVTE
>NZ_CP029196.1|WP_150161786.1|5016619_5017612_-|hypothetical-protein
MGPVSEPIRPRRRGRLARSAAAFAVLLGLASYVAVHQITGSKGTPRCSVGTGDNRYEFTPEQASNAAMISAVGTTRGMPERAVTIALATALQESALRNIEHGDRDSLGLFQQRPSMGWGTPEQIMDPVYSAGKFYDGLEKVPGYSRLPLTVAAQKVQKSGFPQAYAKHEPDATLLAAALTGRSPAALSCTTGEADGLPGDPEKVRAELVRAFGEKAAPQAVTGGPSAGRSAAEPPVLVVPVRAVTGAERAGGPGADERRGWELAQWAVARAETLRITEVAYGDRVWRAGQAAGGWSKVSRAKTSAEPASASEAGDAPAAGGGTVRMRLAQ
>NZ_CP029196.1|WP_150161787.1|5017641_5018736_+|succinyl-diaminopimelate-desuccinylase
MADITPPDAPLDLSQDGAALTAALVDFPSVSGTEQPLADAIEQALRALPHLAVDRYGNNVVARTRLGRGERVVLAGHIDTVPIADNVPSRLDEDGILWGCGTSDMKSGVAVQLRIAATVPEPNRDLTFVFYDNEEVAADLNGLGKIAAAHPDWLEGDFAVLLEPSDAQVEGGCQGTLRVILHTAGERAHSARSWMGSNAIHTAAPILARLASYEPRKPVIDGLEYHEGLNAVAIQGGVATNVIPDACTVTVNYRYAPDRSPAEALAHVREVFADCDIAEFVVDDESPGALPGLSHPAAEAFMKAVGGSAQPKFGWTDVSRFSALGVPAVNYGPGDPIYAHKRDEHVPVDRIHHCEARLRDWLTA
>NZ_CP029196.1|WP_015035973.1|5018820_5019570_+|TIGR00730-family-Rossman-fold-protein
MGIPEGETKPEEQRLGPVLRRRDQVQPGTTDQRLLDTEGDSEWVHTDPWRVMRIQSEFVEGFGALAELPSAISVFGSARTKPDSPEYEAGVRIGRALVEAGFAVITGGGPGAMEAANKGAREAKGVSVGLGIELPFEQGLNPHVDIGVNFRYFFVRKTMFVKYAQGFVVLPGGLGTLDELFEALTLVQTRKVTRFPIVLFGTQYWKGLVDWLRDSVVAGGKASERDLLLFHVTDDVDEAVALVTKETGK
>NZ_CP029196.1|WP_150161788.1|5019675_5020536_-|dihydropteroate-synthase
MLRLGRREFGPHEPVIMAIVNRTPDSFYDQGATFRDEPALARVEQAVAEGAAIIDIGGVKAGPGDEVTAEEEARRTVGFVAEVRRRHPDVVISVDTWRADVGEAVCEAGADVLNDAWGGVDPGLAEVAAKYGAGLVCTHAGGAEPRTRPHRVEYEDVMADILRVTVGLAERAASLGVRRDAIMIDPGHDFGKNTRHSLEATRRLGEMTETGWPVLVSLSNKDFVGETLDRPVKERVLGTLATTAVSAWLGAQVYRVHEVAETRQVLDMVASIAGHRAPAVARRGLA
>NZ_CP029196.1|WP_150161789.1|5020639_5020969_+|hypothetical-protein
MFWFLLITMVVVVAAVTLAVVGGGDSEVLPDVAPEQLVDPLPQARPVDRADVEALRLPVAVRGYRMADVDDVLVRLGAELAERDARIAELEEELAGAAAGDGGAEDGRA
>NZ_CP029196.1|WP_150161790.1|5020965_5021556_+|DNA-3-methyladenine-glycosylase-I
MTAGGAVPGPDGRLRCPWGLSTADYVTYHDEEWGRPVHGDDALFERLCLEAFQSGLSWITILRRREGFRTAFDGFRIASVAEFGDAERERLLADEGIIRNRAKIDATLANAKLLAGWSEGELDELIWSYAPDPETRPAPRTVADVPAVTDESTALSKALKKRGLRFIGPTTAYALMQACGLVDDHVRDCVSRGGGK
>NZ_CP029196.1|WP_015035977.1|5021581_5022385_-|enoyl-CoA-hydratase
MADTVLYEVSDGLATITLNRPEAMNAMNVAAKVALRDAAETAAADPAVRAVLLTAAGDRAFCVGQDLKEHVGLLMADQDNGTRETMNTVRDHYNPITKALAGMKKPVVAGVNGVAAGAGFGFALAADYRVVADTASFNTSFAGVALTADSGVSWTLPRLIGQSRASDLLLFPRSITAQEAYELGIANRLVPSADLAAEAEKVARTLAQGPTVAYAALKESLAYGTDHSLAEALEKEEELQGLAGASEDHTIAVRAFIAKEKPKYLGR
>NZ_CP029196.1|WP_009997451.1|5022697_5022865_+|DUF3117-domain-containing-protein
MAAMKPRTGDGPLEVTKEGRGIVMRVPLEGGGRLVVELTPDEAEALGDALKKVVG
>NZ_CP029196.1|WP_015035978.1|5023030_5023696_-|O-methyltransferase
MRQLRGQERAITANRQTSWSFADAFVAEDDALRWARERAREAGLPSVSPGTGGALRLLAATADAKAVAEIGTGTGVSGIYLLLGMRPDGVLTTVDLQPERQQLAKTAFRAAGFAGNRARFIPGRALDVLPRLADGGYDLVFCDGDRLEYLDYLAESLRLLRPGGLVCFEGVFADGRTVDSGAQPAEVQRVRELLRAVRESQELVPSLLPVGDGLLCAVRRG
>NZ_CP029196.1|WP_078508732.1|5023837_5024599_+|RNA-polymerase-sigma-factor-SigE
MVGAPLDTTRADRGGAAAPVDRGGVLRRLLRSAGEPKSVTDTADRIRTTDSAPTTATFASDAESQAWTPPTWEEIVSTHSGRVYRLAYRLTGNQHDAEDLTQEVFVRVFRSLSTYTPGTFEGWLHRITTNLFLDMVRRKQRIRFDALADDAAERLPSREPSPQQVFNDTHFDADVQQALDTLAPEFRAAVVLCDIEGLSYEEIAATLGVKLGTVRSRIHRGRSHLRKALKHRSPEARAEERALATVGWEAGTA

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Crispr_ID: NZ_CP029196_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_16

5325995-5326136

Orphan

Consensus_repeat	Method
CGGGGCTGGATTTCAGCCCGCCCGGCGTTTGAGGGCACGGCCGCAGGCCGTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_16

>merge|NZ_CP029196|16|5325995-5326136|CRISPRCasFinder
CGGGGCTGGATTTCAGCCCGCCCGGCGTTTGAGGGCACGGCCGCAGGCCGTACGGGGGCGGGCGCAAAGGCTCGCGCCTCAATCGTCGGCGGGGCTGGATTTCAGCCCGCCCGGCGTCTGAGGGCACGGCCGCAGGCCGTAC

>NZ_CP029196|16|12|5325995-5326136|CRISPRCasFinder
CGGGGCTGGATTTCAGCCCGCCCGGCGTTTGAGGGCACGGCCGCAGGCCGTAC	GGGGGCGGGCGCAAAGGCTCGCGCCTCAATCGTCGG
CGGGGCTGGATTTCAGCCCGCCCGGCGTCTGAGGGCACGGCCGCAGGCCGTAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150161934.1\|5319910_5320657_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NZ_CP029196.1\|WP_150161944.1\|5331737_5332628_-\|adhesin	unknown	unknown	gnl\|CDD\|367638
NZ_CP029196.1\|WP_150161938.1\|5326210_5327098_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381314
NZ_CP029196.1\|WP_150163718.1\|5320690_5321299_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_CP029196.1\|WP_150161941.1\|5328598_5329024_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133388
NZ_CP029196.1\|WP_150161945.1\|5335224_5336574_-\|maltokinase	unknown	unknown	gnl\|CDD\|237794
NZ_CP029196.1\|WP_150161933.1\|5318008_5318530_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161937.1\|5324374_5325781_+\|cation:dicarboxylase-symporter-family-transporter	unknown	unknown	gnl\|CDD\|234968
NZ_CP029196.1\|WP_150161936.1\|5322178_5324242_-\|GHKL-domain-containing-protein	unknown	unknown	gnl\|CDD\|225827
NZ_CP029196.1\|WP_150161932.1\|5317430_5317859_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161940.1\|5328101_5328569_+\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP029196.1\|WP_150161939.1\|5327097_5327991_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187575
NZ_CP029196.1\|WP_150161931.1\|5317070_5317358_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240291
NZ_CP029196.1\|WP_150163719.1\|5332771_5334958_-\|1,4-alpha-glucan-branching-enzyme	unknown	unknown	gnl\|CDD\|235445
NZ_CP029196.1\|WP_030320481.1\|5336820_5338533_-\|maltose-alpha-D-glucosyltransferase	unknown	unknown	gnl\|CDD\|274140
NZ_CP029196.1\|WP_150161930.1\|5315192_5316218_+\|ATP-dependent-6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP029196.1\|WP_150161943.1\|5329519_5331763_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP029196.1\|WP_150161935.1\|5321477_5322182_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NZ_CP029196.1\|WP_150163717.1\|5318559_5319351_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161942.1\|5329020_5329359_+\|thioredoxin-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|200072

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150161934.1\|5319910_5320657_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	4.44715e-75
NZ_CP029196.1\|WP_150161944.1\|5331737_5332628_-\|adhesin	gnl\|CDD\|367638	pfam03756, AfsA, A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.	1.77129e-18
NZ_CP029196.1\|WP_150161938.1\|5326210_5327098_-\|aldo/keto-reductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	1.25889e-97
NZ_CP029196.1\|WP_150163718.1\|5320690_5321299_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	0.000168004
NZ_CP029196.1\|WP_150161945.1\|5335224_5336574_-\|maltokinase	gnl\|CDD\|237794	PRK14705, PRK14705, glycogen branching enzyme; Provisional.	3.47637e-80
NZ_CP029196.1\|WP_150161937.1\|5324374_5325781_+\|cation:dicarboxylase-symporter-family-transporter	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	5.09192e-164
NZ_CP029196.1\|WP_150161936.1\|5322178_5324242_-\|GHKL-domain-containing-protein	gnl\|CDD\|225827	COG3290, CitA, Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms].	4.84539e-121
NZ_CP029196.1\|WP_150161940.1\|5328101_5328569_+\|AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	2.42957e-33
NZ_CP029196.1\|WP_150163719.1\|5332771_5334958_-\|1,4-alpha-glucan-branching-enzyme	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NZ_CP029196.1\|WP_150161939.1\|5327097_5327991_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187575	cd05265, SDR_a1, atypical (a) SDRs, subgroup 1. Atypical SDRs in this subgroup are poorly defined and have been identified putatively as isoflavones reductase, sugar dehydratase, mRNA binding protein etc. Atypical SDRs are distinct from classical SDRs. Members of this subgroup retain the canonical active site triad (though not the upstream Asn found in most SDRs) but have an unusual putative glycine-rich NAD(P)-binding motif, GGXXXXG, in the usual location. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.95119e-72
NZ_CP029196.1\|WP_150161931.1\|5317070_5317358_-\|hypothetical-protein	gnl\|CDD\|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	0.00332886
NZ_CP029196.1\|WP_150161930.1\|5315192_5316218_+\|ATP-dependent-6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	6.18395e-173
NZ_CP029196.1\|WP_030320481.1\|5336820_5338533_-\|maltose-alpha-D-glucosyltransferase	gnl\|CDD\|274140	TIGR02456, Trehalose_synthase, trehalose synthase. Trehalose synthase interconverts maltose and alpha, alpha-trehalose by transglucosylation. This is one of at least three mechanisms for biosynthesis of trehalose, an important and widespread compatible solute. However, it is not driven by phosphate activation of sugars and its physiological role may tend toward trehalose degradation. This view is accentuated by numerous examples of fusion to a probable maltokinase domain. The sequence region described by this model is found both as the whole of a trehalose synthase and as the N-terminal region of a larger fusion protein that includes trehalose synthase activity. Several of these fused trehalose synthases have a domain homologous to proteins with maltokinase activity from Actinoplanes missouriensis and Streptomyces coelicolor (). [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP029196.1\|WP_150161941.1\|5328598_5329024_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	2.74612e-38
NZ_CP029196.1\|WP_150161943.1\|5329519_5331763_+\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	1.35981e-104
NZ_CP029196.1\|WP_150161935.1\|5321477_5322182_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	2.22925e-64
NZ_CP029196.1\|WP_150161942.1\|5329020_5329359_+\|thioredoxin-fold-domain-containing-protein	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	4.01119e-33

>NZ_CP029196.1|WP_150161937.1|5324374_5325781_+|cation:dicarboxylase-symporter-family-transporter
MDSRGVHRDVDTHQHEEDPVAARRDRTHYLYLAVIGAVLLGIAVGFLAPGVAVELKPLGTGFVNLIKMMISPIIFCTIVLGVGSVRKAAKVGAVGGLALGYFLLMSTVALAIGLLVGNILEPGSGLHLTKELAEAGAKQAEGASESTPDFLLGIIPTTIVSAFTEGEVLQTLLVALLAGFALQAMGSAGEPVLRGIGHIQRLVFRILAMIMWAAPVGAFGAIAAVVGATGAAALKSLAVIMIGFYLTCAIFVFVVLGTILRLVAGINIWTLLKYLGREFLLILSTSSSESALPRLIAKMEHLGVSKPVVGITVPTGYSFNLDGTAIYLTMASLFVAEAMGDPLSVGEQISLLVFMIIASKGAAGVTGAGLATLAGGLQSHRPELVDGVGLIVGIDRFMSEARALTNFAGNAVATVLVGTWTKEIDKERVAEVLAGRVPFDETTLVDDHGAAVPEQRAEDGEEKARAGV
>NZ_CP029196.1|WP_150161936.1|5322178_5324242_-|GHKL-domain-containing-protein
MRLPLPLPRPRSLAGQLFAMQVVLVAVVVAGCAVFAYVTDRAQAEETARRQATATAAAVADSPSVVAAARSDEPSALLQPYAESLRRHAGVAFVVIMAPDGTRWTHPEPEQIGRTYLGHIEQARAGRTYTETHLGVLGPSVRTVAPVFDGDRVVALVSAGITIDKISEQVREQVVALLGMAGAALVLGGAGTYVVNARLRRHTHGMNATELSRMHDYHEAALHAVREGLVMLDGRRRIALINDGARELLGLDEGVVGRPAAELGLPAPLTGALLSSEPRVDETHLTADRVLVVNTRPVVGGERRGTVVTLRDRTELQALSGELDSERGFTEALRSQAHEAANRLHTVVSLIELGRVAEAVEFATAELELAQALTDRVVDAVGEPVLAALLLGKAAQANERGVELVLTEDSRIDDGLVPATLPARDLVTILGNLIDNAVEAAGGTPQARVTVTVAARTGDGELLLRVGDTGPGVRPADRDAVLGRGWTTRGPGRGLGLTLVGQAVTRASGTLDITATKEGGAQFTARLPLPEPAPEAPAGADAEPAVRGRRPEPTGLPEPAQPAVLRASGSLDTPDPAEAGPEPAVRPAPPEPALIPPTRDGGTDGGSRPPAASVTGSDSGPAASSASTPGPCRAANSGTGSSSASAPDPHPDPAPGPGPDSGPGSGPGPDPAPRPGVGPHGAKEVTP
>NZ_CP029196.1|WP_150161935.1|5321477_5322182_-|response-regulator
MSSTPPPSLRVLVVEDDPVAADAHALYAGRVEGFTVVGVAHSRAAAVRLLDRTPVDLILLDLYLPDGHGLQLLRSLRAAGHSADVIAVTSARDLAIVREGVSLGVVQYVLKPFAFATLRDRLARYAEFRATAGEASGQEEVDRALATLRAPHPAALPKGLSAPTLESVTRTLRSTPAGLTAAEAGAAVGISRITARRYLEHLVTAGRAVRAPQYGQIGRPELQYRWLDGPARGH
>NZ_CP029196.1|WP_150163718.1|5320690_5321299_-|helix-turn-helix-domain-containing-protein
MAPDHVAYGLRAQYGLFVTPDAVVAWERGRAVPDEQQLTALAGVLWCSPAELIAAPATLREHRMARGLAPEELALRVGVAAHAYQRMEDEGRWRGTERQTAALAEVLGLGPRALITATGGDERLAELLRHAATTRWQAYVKPAAKMLPLPRRTVEFALQRLHGEYHARMAATSSWGASGATGDEGRAYLDGITGHFWAAVGS
>NZ_CP029196.1|WP_150161934.1|5319910_5320657_-|tyrosine-protein-phosphatase
MRRHIPFERLHNFRDLGGYPTADGGTVRWETLYRSDSLAKLADAGPTDLERFRSLGVATVIDLRYPWEIAAKGRLPETEDVSWHNLSVEHRPYDQEAIDPALDPWRYLADRFAEVAEDGAVELRTALEVIAAADGPLVFHCASGKDRTGLLAALVLALLGVPDEEILADFALTELATERLIADWRAAHPGREPRWPGYGRAPADIMRLFLADLRARYGSVDAYVTGHVGLDPSVVTTLRARLVDAPKA
>NZ_CP029196.1|WP_150163717.1|5318559_5319351_-|hypothetical-protein
MVQEEIEADPELRRQLQLQLTAPGTNATGSLLITGSQVSRSSIALGPLTINNTRGGRAVIALTAALLLALVVLVVYGGTRLITVDDSPGSSQDDSARHATRALNVSEVKQVVPDLTSMPSGWERSAPLRAGKDEDNGCSGAQASFNTNNWNDGTNTRKVWAEFTVRSCPSAALTAQGFEEIRSGVANNNKAREISLPELGDQRTAITHYNSGLDETTAVALLRVGTVLVELEYQPVPEDSGWSREFEQLASMVAARAQQVQNA
>NZ_CP029196.1|WP_150161933.1|5318008_5318530_+|hypothetical-protein
MNVLLGDKSRFAAEVGEPGPLCRVDLWAAGKWLTCDDNMAYVPQFRRDVLDAAAWLRSGEGSSLPFDGLSAEATHRRLWQRAGDDDESEDDHQLSSRFRFLLWGPTTDNVVAHLFRERDHVVITLEFWREEHLFTHPEDAGAVFVVEVPAEEFIGILEGIAAALDAPSSERRS
>NZ_CP029196.1|WP_150161932.1|5317430_5317859_+|hypothetical-protein
MAGTELCLAERRGTRTGQIHQVPCAEAGVPLYSLAEVGGGRWRIVSDHPDFGPGCSGIPSGGRIPDAPYEDSECGDPSRVEAFALEPYGTPVRGYRIVPAGSATPGSCVTVVGDRAAPWARLAQAPCAPDASGQLFSFERRP
>NZ_CP029196.1|WP_150161931.1|5317070_5317358_-|hypothetical-protein
MPFPEQRDDTDPGEHEPGHRDDGDDGTPYPGGRGHRLAGSPLGRGPHGRAPGGGDDFGPIRVEAGGAGGVGGAGGGARAGGAGGGARAGGGGGGA
>NZ_CP029196.1|WP_150161930.1|5315192_5316218_+|ATP-dependent-6-phosphofructokinase
MRIGVLTAGGDCPGLNAVIRSVVHRALTGHDDEVIGFEDGFKGLLDGHYRPLDLNAVSGILARGGTILGSARLERNRLAEAAESAPDLAREYGIDVLIPIGGEGTLTAARMLSDAGMPVVGVPKTIDNDISSTDRTFGFDTAVGVATEAMDRLKTTAESHQRVMVVEVMGRHAGWIALESGMAGGAHGICLPERPFQVDDLVKMVEERFARGKKFAVICVAEGAHPAEGSMEYKKGEIDQFGHERFQGIGNQLAVELERRLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAAHRGEFGKMTALRGTGVEMVPLAEAVTQLKRVPEDRMREAESVF
>NZ_CP029196.1|WP_150161938.1|5326210_5327098_-|aldo/keto-reductase
MRHRALGDVRVGAIGLGAMPLSIEGHPDEARALATIHAALDAGVTLLDTADSYHPPGGEPGANELLVARALAAYGGRGRTEDVLVATKGGRGRTADGGWTVDGRPEHLRRAAEASARRLGVDAIGLYQLHKPDPAVPYAESLGAIRELLDAGTIRLAGISNVDTDRIRLAREILGERLVSVQNRYSPADRGSEPELRLCAELGLAFLPWSPLGGIARSSLDGASTLAADPELGAFHRVARTHGVSPQRVALAWLLTRSDTVLPIPGASRPESIRDSAEAGALRLTEMEIAELNGT
>NZ_CP029196.1|WP_150161939.1|5327097_5327991_-|NAD-dependent-epimerase/dehydratase-family-protein
MDILIIGGNRYFGKRLTLRLLESGHDVTMLNRGSSGVPEGVAHLIADRNDENALESALGDRTFDVVIDQVCYTPVQAAIARRVLGPRTRRYVMTSTVEIYEFQHSATPLREDAVDPRTVTVDPGLPWADPEFLEAHYGEGKRQAEAVFAAAPAFPYTAVRVAHVLGGEDDFTGRIGHYADRIRAGEPIAVPAENHPATYVYVEEIAAFLAWAAEESFTGPVNAHSHGALTTADICAEIERLTGGRTVFQKVEVGEVSPFSFTRSYAMDNSRATELGFAFRDSTAWLPQALSETLGAN
>NZ_CP029196.1|WP_150161940.1|5328101_5328569_+|AsnC-family-transcriptional-regulator
MGAFDPIDRQILDLLQTDGRIKLSELGRRVRLSPAAVTERVRRLEACGAVTGYGAHVSPARLGYGIRAFIRVNPHGGYTLKHPRTLELTARPEVLEVHHVVGEDCWILKVAVTDTVHLEEVLEQTSALGRTTTSIVLSSPVERKPLLPPGGTPLP
>NZ_CP029196.1|WP_150161941.1|5328598_5329024_+|MerR-family-transcriptional-regulator
MRIGELAERAGTTTRTLRYYESRGLLTARRTEQGHRTYDEADLRLLQQIRTLQDFGFELEETRPFVDCLRAGHPAGDSCPASIAVYRRKVAELDGLIEQLRAVRAQVGAQLLRAEAELEHGPEPRCELGAQWETETERGRE
>NZ_CP029196.1|WP_150161942.1|5329020_5329359_+|thioredoxin-fold-domain-containing-protein
MTTYAEGVAEVTDGDFEAEVLGSGLPVLVKFTAEWCGPCRQLKPVLGAIAAEEAERLRIVEIDVDRNPETTLRYGVLATPTMLVFRAGEPVKSLVGARPKRRLLEELADVLV
>NZ_CP029196.1|WP_150161943.1|5329519_5331763_+|AAA-family-ATPase
MSTEEFRNEQQFITDLYARLDDLRTEAEAAVERALRTPGVGSNQGRLERDVLVAEQSGLLSALNAGESGLCFGRLVFKDGRDHHIGRLGIREDDPNRTPLVLDWRAEIARPFYLATGYEPMGLSRRRHISTLGRTVTALHDEVLDLADATRTGHESRDADEVLLAALDAARTGRMHDIVQTIQAEQDAIIRSPHRGVLVVEGGPGTGKTAVALHRAAYLLYAHREQLAKRAVLIVGPNPAFLGYIGNVLPSLGETGVLLATPAELFPGVRATGTDTARAAAVKGSAAMAEALAAAVRDRQQVPERGEPLIVPHEDGDLVIDWDMALEARHKARETALPHNLARPYFVFRILDALADQLADRIGADPYGGPNFLGPDDIALLAKGIAGNPEVYAAIDTLWPALTPQDFLADYLAEPTHLTDEDAGAIRRDGGAWTPADVPLLDEAAELLGEDDSAARAAEEAERQKQIQYAQGVLDVSYASRTYEFEDKEEQDKDASEVLSAHDIIDAERFAERHEEADHRTAAERAAADRTWAFGHIIVDEAQELSAMAWRLLMRRSPSRSMTLVGDPAQTGDPAGVGAWERILAPYVEDRWELVRLGVNYRTPAEIMAVAAEVRRADDPGFEPPSSVRSTGVEPWDRTVDDPVKEAADAVATERREEGRIAVIAPPELHPGLVAALPDAAYGPAPDLTRPVVLLDPRQAKGLEFDTVLVVDPEGIVAGAAHGTNDLYVALTRATQRLGIIRSAARR
>NZ_CP029196.1|WP_150161944.1|5331737_5332628_-|adhesin
MRDTVERRLSPELCHRVRSEDTFPVEWRPLDGKDRFAVRAAWPADHPFFTPVRRGAERCHDPLLLVETLRQSTMALLHDAHGLPLSRHILLGEISLACDPAGLTVTGEGADIEVRFAELLRRGDQLSDTRVDWIVRRGARAVATGGARARFVGPAAYRRLRGGHVEAGAVRPGPRVRRAPAPLTGRARTEDVLLAPGGREGVWKLVVDTGHPQLFQRPNDHIPGMLFLEAARQAASAAAWPRPCLPAALRIVFDRYAEFDGGPCLLRVESGRAAGEFEVTGYQDGARLFTCGLRSG
>NZ_CP029196.1|WP_150163719.1|5332771_5334958_-|1,4-alpha-glucan-branching-enzyme
MDPGDRARLLAGEHHDPHGVLGAHPVRGGVAVRVLRPWAKEVTVVTKGKRVPLRHEGDGIFSGLLPLLRKVPAYELRVRYGDDASDELALHDPYRFLPSLGDLDLHLIGEGRHEELWTALGSHVMTHDGVTGTRFAVWAPNARGVRVTGDFTHWDGTGLPMRSLGSTGVWELFVPGIGEGALYKYDITRPDGTHTVRADPMARRTECPPNTASIVTASHYTWDDAEWMRRRGDRPPHEAPISVYEVHLPSWRPGLTYRQLAEQLPAYVRDLGFTHVELMPVTEHPFGGSWGYQVTGFYAPTARMGTPDDFRFLVDALHRAGIGVLMDWVPAHFPKDDWALAEFDGRPLYEHEDPRRSHHPDWGTLEFDYGRKEVRNFLVANAVYWCQEFHIDGLRVDAVASMLYLDYSREHGEWLPNEFGGRENLDAVRFLQEMNATVYRRCPGVVTFAEESTAWDGVTRPTDQVGAGGFGGLGFGMKWNMGWMHDSLEYMQKEPVHRKYHHHEMTFSMVYAYSENYILPISHDEVVHGKRSLVSKMPGDWWQQRANHRAYLGFMWAHPGKQLLYMGQEFAQGAEWSADHGPDWWLLDPAYGAEPDHRGVRDLVRDLNTVYAATPSLWERDTAPEGFQWVVGDAAEDNVFAFLRFDAFGSPLLAVSNFSPVVRHDYRLGVPDQVVAWAEVLNTDAGRYGGGDVVGRDPLKTESVPHHGRAASIRMTLPPLATVWLRPA
>NZ_CP029196.1|WP_150161945.1|5335224_5336574_-|maltokinase
MPETASTTRAPDALLPSLAPLLHEWLPRQRWFAGKGRRVTGFTLDAATELLPLDGAGPGLLHLLVRVEQPSRPAGTPADCYQLVLGVRPQLPPRLAPALIGRIRQGPLAGRAVYEGLRDPRLAGLLYERLRTPGRTGPLRFHATTSLPPALAPRMLDAEQSNSSLVYGDSFILKIFRRVSPGANPDLELPLALAGAGCARVPAPVAWFESGASTLGVLQPYLRDSRDGWRLALDALADGREFTAEARALGRATAEVHLALASALPTRRLGRAETERLAAAMDHRLHAAAQAVPALLPYVPGLRAVFAAASGTTGDGVVQRIHGDLHLGQTLRGSDGGWAVIDFEGEPAKPLDERRSPQPTVRDVAGMLRSFDYAARTHRPWNADWAARCRAAFCSGYAEAAGTDPRADPALLRAYETDKAVYEVVYEARHRPDWLPVPMSAIQRLSTTP
>NZ_CP029196.1|WP_030320481.1|5336820_5338533_-|maltose-alpha-D-glucosyltransferase
MTVNEPVPDTFEDTPAKDRDPDWFKRAVFYEVLVRSFQDSNGDGVGDLKGITSKLDYLQWLGVDCLWLPPFFKSPLRDGGYDVADYTSVLPEFGDLADFVEFVDAAHQRGMRVVIDFVMNHTSDQHEWFQESRRDPEGPYGDYYVWADDDKQYADARIIFVDTESSNWTFDPVRKQYYWHRFFSHQPDLNYENPAVQEEILSALKFWLDLGIDGFRLDAVPYLYQQEGTNCENLPATHAFLKRVRKEIDDHYPDTVLLAEANQWPEDVVDYFGDFRSGGDECHMAFHFPVMPRIFMAVRRESRYPVSEILAKTPEIPSGCQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMRANIGIRRRLAPLLDNDRKQMELFTALLFSLPGSPVLYYGDEIGMGDNIWLGDRDGVRTPMQWTPDRNAGFSSCDPGRLYLPAIMDPVHGYQVTNVEAGMASPSSLLHWTKRMIEIRKQNRAFGTGTYTELPASNPAVLAFLRETAPEEGMDADLVLCVNNFSRFAQPTELDLRRFDGTQPVELIGGVTFPAIGQLPYLLTLAGHGFYWFRLKKG

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Crispr_ID: NZ_CP029196_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_17

5435614-5435704

Orphan

Consensus_repeat	Method
GCCGCCCTCGCTGCCGCTGTAGCTGGACTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_17

>merge|NZ_CP029196|17|5435614-5435704|CRISPRCasFinder
GCCGCCCTCGCTGCCGCTGTAGCTGGACTTGCGCCAGTCGTAGGCGACTTCGAGGCAGTTGCCGCCCTCGCTGCCGCTGTAGCTGGACTTG

>NZ_CP029196|17|13|5435614-5435704|CRISPRCasFinder
GCCGCCCTCGCTGCCGCTGTAGCTGGACTTG	CGCCAGTCGTAGGCGACTTCGAGGCAGTT
GCCGCCCTCGCTGCCGCTGTAGCTGGACTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_015036350.1\|5430023_5430320_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP029196.1\|WP_150161978.1\|5427802_5429917_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP029196.1\|WP_150161977.1\|5425290_5427471_+\|NAD-dependent-DNA-ligase-LigA	unknown	unknown	gnl\|CDD\|236137
NZ_CP029196.1\|WP_150161979.1\|5430325_5431822_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP029196.1\|WP_150161983.1\|5435726_5436554_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|213767
NZ_CP029196.1\|WP_150161985.1\|5437191_5438205_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176189
NZ_CP029196.1\|WP_150161989.1\|5440375_5442487_+\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NZ_CP029196.1\|WP_150161990.1\|5442675_5444970_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP029196.1\|WP_015036346.1\|5423572_5424271_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181298
NZ_CP029196.1\|WP_150161988.1\|5439234_5440164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161984.1\|5436667_5437093_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP029196.1\|WP_150161992.1\|5445553_5446156_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161980.1\|5432077_5433589_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP029196.1\|WP_150161981.1\|5433680_5435396_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378342
NZ_CP029196.1\|WP_150161991.1\|5444947_5445505_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP029196.1\|WP_015036345.1\|5423025_5423565_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|367590
NZ_CP029196.1\|WP_041662892.1\|5431827_5432061_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161987.1\|5438529_5439075_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_015036347.1\|5424273_5425275_+\|methionine-synthase	unknown	unknown	gnl\|CDD\|239426
NZ_CP029196.1\|WP_150161986.1\|5438201_5438546_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015036350.1\|5430023_5430320_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	2.20028e-37
NZ_CP029196.1\|WP_150161978.1\|5427802_5429917_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.35942e-103
NZ_CP029196.1\|WP_150161977.1\|5425290_5427471_+\|NAD-dependent-DNA-ligase-LigA	gnl\|CDD\|236137	PRK07956, ligA, NAD-dependent DNA ligase LigA; Validated.	0
NZ_CP029196.1\|WP_150161979.1\|5430325_5431822_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP029196.1\|WP_150161983.1\|5435726_5436554_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	8.35815e-06
NZ_CP029196.1\|WP_150161985.1\|5437191_5438205_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176189	cd05286, QOR2, Quinone oxidoreductase (QOR). Quinone oxidoreductase (QOR) and 2-haloacrylate reductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. 2-haloacrylate reductase, a member of this subgroup, catalyzes the NADPH-dependent reduction of a carbon-carbon double bond in organohalogen compounds. Although similar to QOR, Burkholderia 2-haloacrylate reductase does not act on the quinones 1,4-benzoquinone and 1,4-naphthoquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	5.80765e-171
NZ_CP029196.1\|WP_150161989.1\|5440375_5442487_+\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NZ_CP029196.1\|WP_150161990.1\|5442675_5444970_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	6.52887e-94
NZ_CP029196.1\|WP_015036346.1\|5423572_5424271_+\|SDR-family-oxidoreductase	gnl\|CDD\|181298	PRK08219, PRK08219, SDR family oxidoreductase.	1.52991e-114
NZ_CP029196.1\|WP_150161984.1\|5436667_5437093_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	4.24362e-20
NZ_CP029196.1\|WP_150161980.1\|5432077_5433589_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP029196.1\|WP_150161981.1\|5433680_5435396_-\|hypothetical-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	2.55232e-22
NZ_CP029196.1\|WP_150161991.1\|5444947_5445505_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	9.60572e-25
NZ_CP029196.1\|WP_015036345.1\|5423025_5423565_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|367590	pfam03641, Lysine_decarbox, Possible lysine decarboxylase. The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear.	1.33473e-39
NZ_CP029196.1\|WP_015036347.1\|5424273_5425275_+\|methionine-synthase	gnl\|CDD\|239426	cd03310, CIMS_like, CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to L-homocysteine without using an intermediate methyl carrier. The active enzyme has a dual (beta-alpha)8-barrel structure, and this model covers both the N-and C-terminal barrel, and some single-barrel sequences, mostly from Archaea. It is assumed that the homologous N-terminal barrel has evolved from the C-terminus via gene duplication and has subsequently lost binding sites, and it seems as if the two barrels forming the active enzyme may sometimes reside on different polypeptides. The C-terminal domain incorporates the Zinc ion, which binds and activates homocysteine. Side chains from both barrels contribute to the binding of the folate substrate.	1.02571e-66

>NZ_CP029196.1|WP_150161981.1|5433680_5435396_-|hypothetical-protein
MCLVPVIRSSSPLSRRAARAGAVLLVASSLQLTTPATAEPTPDHPALGAVFPLGDHSAPKTGSKELAPGVTYRVFTQGAANDVWTVWVRYDDGQEVTTGRTTATALAEKLRTAGYGDARVVPLDSPATADTYAQTFYGVHVGSYATATEAKALQEELKTKGFADSRTLYTAETNADSRGPWQIRVITVRPDAQVDLRTEHGTTVSGSETVRQLSAAAGALAAVNGTEFDIDSVNNTAFMGHEGVPQGLYMKNNVLLGSSNNGRTALLLNAAGGGHRITEVKSRTWITAPDGTERDVDGINRVAGQILGCGGVGDDFRKTASLGNVPRLDPWRNGICYDPNEIVVFRPEWGTTTPAPAKEWAGTPVTEVVTNGNWDVLFLRDAPGPIPAGGRVLQGIGKGREWLRTLKPGDRVTPHTTVTDTAGTPVTAPALSAVGAGTPALMRDGQVWLNPAANGMAHVACVLPAPATGCRPSGALTARHPRTLAGISPEGHLMLVTIDGRNPGTSVGVTLPEAARVMEWLGARDAVGLGSGGDTTLMVENTLYNRPRDQWSDTASHERAVSNAVVVVPRS
>NZ_CP029196.1|WP_150161980.1|5432077_5433589_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTVTELLSYEAALAEYDPVMGLEVHVELGTKTKMFCGCSTELGAEPNSQTCPTCLGLPGSLPVVNAIGVESAIKIGLALHCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFNGYLDVQLEDGEVFRVEIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGIPLIEIVTKPIEGAGERAPEVAKAYVAELRELIRALGVSEARMDKGQMRCDVNLSLRPHGTKTFGTRSETKNVNSLRSVERAARFEIQRHAAVLSSGGSIVQETRHFHEDDGSTTSGRIKDNAEDYRYFPEPDLVPVAPAREWVEELRGGLPELPRVRRNRLREEWAVSEQEMQSILNAGAVDAIVATTEAGADAASARKWWMGELARNANEKGVSLEELPITPADVARVSALVAGGDLNDKLARQVIEGVLAGEGTPDEVVEKRGLKVVSDDGALGAAVEEAIAGNAAIADKIRGGKVAAVGALVGAVMKATRGQADAAKVKDLILEKLGVSEG
>NZ_CP029196.1|WP_041662892.1|5431827_5432061_+|hypothetical-protein
MAKKAKNFKKSKTGVYVSLATTAFGAISVAKQAKLARNDHDMLRLIDSAVSAAAIVTGLAILYRELKRLGDDDVLLG
>NZ_CP029196.1|WP_150161979.1|5430325_5431822_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MTDNIIKLTAAEIAGKIAAGELTAVEVTEAHLARIEAVDEKVHAFLHVDREGALAQARAVDEKRARGEKLGPLAGVPLALKDIFTTAGMPTTVGSKMLEGWIPPYDATLVKNLKAADVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTRIPGGSGGGSSAALAAYEAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGGVSRYGMVAFSSSLDQGGPCARTVLDAALLHEAIAGHDPLDSTSIDAPVPPVVEAARNGSVAGMRVGVVKQFRGEGYQAGVVQRFDESVELLKSLGAEIVELDCPTFDLALSAYYLIAPSECSSNLARFDAMRYGLRVGDDGTRSAEDVTALTREAGFGDEVKRRIILGTYALSSGYYDAYYGSAQKVRTLITREFEKAFEDVDVIVSPTTPTTAFPIGERADDPMAMYLADLCTIPTNLAGNAAMSLPCGLAPEDGLPVGLQIIAPAMKDDRLYKVGAAVEAAFVEKWGHPLLEEAPSL
>NZ_CP029196.1|WP_015036350.1|5430023_5430320_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPGITREEVAHLARLARLELKGEELDHFAGQLDDIIGAVARVSEVADQDVPPTSHPLPLTNVMRADEVRPSLTPEQALSGAPAQEQQRFKVPQILGED
>NZ_CP029196.1|WP_150161978.1|5427802_5429917_+|EAL-domain-containing-protein
MEPTESAAPVPRPHGRVSPEGFTSRLPAAVVGIAAVVLVAGLQQALTTGHGLFPDGVTGWSLAVLTGLIVGHLVALGRDRWWGGTGSGAALTLAVLLLYGWVPAGLVSMTVVALVGAARRHRWRQGVLHGAADVLGVAVAALVLALFGDVPTVEQPWQPLDWTIGDLPEVVLAAATYLVVTRLLLWYTLAPQGRGLPTVARTALLRQGLVAVALLGIAPLICVVAASSPVLLPLFAVPLIALDSTLWIARARAEEQLRDPLTGLPNRQWLLERAWTALEEAEGEGARAALVLIDLDRFRSVNDTLGHLAGDRLLLQIAERLRLALPRGAEAARLGGDEFAVLLPTADSTTSAQRVARHLVAELSSPLDLDGLTLVLEASAGVAVFPDHALDAEGLLRRADVAMYQAKRDRTGVEVYESKRDSNTPDRLGLLGDLRRALDAGEVELHYQPKVQFDGQVAGLEALVRWVHPERGKVPPDEFIAIAESSGLMPHLTEYVLETALAQVARWRAQGLNVPVAVNVSPRDVHTPGFAGAVAARLARHGVPAGALQLEITEHVLLEDPQRAADTLNGLTGHGVKMSLDDFGTGYSSLVHLRRLPVSELKIDRSFVARLAVDTEDAEIVRCTVDLAHSLGLLVVAEGVEDDETWERLRDLGCDAVQGWLVAAAMPPGEATAWLLARGEHGWRRPADIAAELAVDHPSGQVVQ
>NZ_CP029196.1|WP_150161977.1|5425290_5427471_+|NAD-dependent-DNA-ligase-LigA
MAVEQGALPAEAREKHAELAEQIEEHRFRYYVKDQPVISDGEFDKLLRALEALEEEYPELRTPDSPTQKVAGQYETDFTSVEHRERMLSLDNAFDDEELATWADRVARDVGTPDFHYLCELKVDGLAVNLTYEHGRLTRAATRGDGRTGEDITPNVRTIADIPERLRGDRVPDLVEIRGEVYFPMEAFEGLNARLVEAGDKPFANPRNAAAGSLRQKDPKVTASRPLHMVVHGIGAREGFDISRLSDTYELLHEWGLPTARHNKVVGSLGEVREFIAYFGENRHSVEHEIDGVVVKLDEIPLQGRLGSTARAPRWAIAWKYAPEEVNTKLIDIKVGVGRTGRVTPYAQVEPVTVAGSEVEFATLHNQEVVKAKGVLIGDTVVLRKAGDVIPEILGPVADLRDGSEREFVMPAECPECGTPLRAMKEGDIDLRCPNARTCPAQLRERLFFLAGRQCLDIENFGAVAAAALTRPLEPAEPPLVDEGDLFDLTIEQLLPIKAYVLDPDSGLPRRDPKTGEEKIVTVFANQKGEPKKNALAMLENIAAAKTRPLARFINGLSIRHVGPVAAEALAREFRSLERIEQASEEELAAVDGVGGIIAAAVKQWFSEEWHREIVRKWRAAGVSLEDEGAGEDVGPRPLEGLTVVVTGTLENFTRDGAKESLQSLGAKVTGSVSKKTSFVVVGENPGSKYDKAMQLKVPVLDEGGFKVLLEQGPEAAREAAVPVAE
>NZ_CP029196.1|WP_015036347.1|5424273_5425275_+|methionine-synthase
MGDDTKLFGSATGVGSLPGGDAREAAKTVTGSFEDFPFLAELPARGPGADMIGRTVGMLVDLYAHVEPSGWRISDRPGRDTKRARSWLGEDLDALEEFTQGYEGPLKVQAVGPWTLAAALELRGGEAALGDAGACRDLVGSLAEGLHGHLAELRKRIPGAELVLQLDEPSLTAVLRGHVRTASGYRTYRAVDRQVVESALREVVAVHDGPVVVHSCAPDVPFALLRRAGAAGVSFDFSLLTERDEEPIGEAVEAGTKLFAGVVPSTDTALSDPGGSVMGVRTLWRRLGLNPGTLAESVVVTPTCGLAGASPAYARAALAHCARAARSLADNPE
>NZ_CP029196.1|WP_015036346.1|5423572_5424271_+|SDR-family-oxidoreductase
MVTMATHVITGAGSGIGAAVARRLHARGDELVLHARDAGRAKELAGRFPGARTLVGDLADPDRLSWAFSHQSLPERVDGLLHIAGVVDLAPVGDLTPKTWHHQLNVNLIAPAELTRHFLPQLRVSQGHVVFVNSGAGLAAHAEWSAYAASKHGLKALADSLRHEEHGNGVRVTSVYPGRTASPMQAKVHQQEGKEYDPSRWIDPESVATAILTAIDLPRDAEINDLTVRPGR
>NZ_CP029196.1|WP_015036345.1|5423025_5423565_+|TIGR00730-family-Rossman-fold-protein
MNICVFLSAADLDERYTGPARDFARLLGKAGHTLVWGGSDTGLMKVVADGVEEAGGRLVGVSVDFLAHKARPGVDEMVVAKDLAERKALLLAKSDAIVVMVGGTGTLDEATEILELKKHGKHSKPVVVLNTAGFYDGLKDQFRRMEEEGFLPVPLAGLALFADDAPTALAHLEENIASR
>NZ_CP029196.1|WP_150161983.1|5435726_5436554_-|helix-turn-helix-domain-containing-protein
MQRGTNSRKKVPSWEVVGALVALYRKQAGLTQPQLAAQACVGLETLGSIEQGRRALRLGLAGELDGILSTGGALAVAVGKAPKKERYPAFAQEFIELEAQALSLCSYENAVVPGLLQTPEYARAVLDCLYPPITPQEAEDRMLDRLDRQRIFEQTPWPPMMSFLLDESILEKTIGGREVLRGQILHLREMAELPFLGLQIIPKSRTTHAGLDGPMVLLETPDHEHVAYIEGQRVSFLIDDPDEVGILQAKYGMLRSQALTPEDTMGLLERLAGVT
>NZ_CP029196.1|WP_150161984.1|5436667_5437093_+|ATP-binding-protein
MSDELPLFREAFYRRERRSVPLARDFARKALADWGLDARADDVLVCVSELATNALRHGVPPGRGYRLHLYLERPGPLRVEVHDSGDGTPAVREPSGESGRGLLLVGALADRWGVGARRPGKIVWCEFAPAEGGPEAFPDSP
>NZ_CP029196.1|WP_150161985.1|5437191_5438205_+|zinc-binding-dehydrogenase
MRAIQVYEVGGPEVLREAEVDPPRPGPGEAVVEVAASGVNFLDVYHREGRYTLPLPFTPGAEGAGTVVEVGPGVTDVAVGDRVGWVEIPGTYAERAVVDASRLVPLPDDIDFETAAAVLLQGMTAHYLIKDAYPVQGGDTVLVHAAAGGMGLLLTQLITHLGGRVIGTTSTAAKAELAKRAGAAEVILSSAVDDLAAEVRRLGGGQGLPVVFDGVGAHTFDASLASLRPRGHLVLFGAASGAVPPFDPIRLAHGGSLTLIRPSLGDFIADRSELLRRAADVFEWVRSKALEVTVTGRYGLSEAAQAHSDLEARRTTGKLLVIPGAAADLPGLPGRSG
>NZ_CP029196.1|WP_150161986.1|5438201_5438546_-|hypothetical-protein
MTGNGDFHIGSMRDFYNASGDGAVGRIEYHQQGTDPQAVYEAVIRAIETLRSQVSAEDREVLDASLETIRQGDEAPPGAFRRALGTAAGVAALVGEVGAPVAEAVRQMLALLAG
>NZ_CP029196.1|WP_150161987.1|5438529_5439075_-|hypothetical-protein
MARRKVIRVEVSKRVLWIGASAYPLQNIARATTVSIKPRRARAVGTFVKAVLSVGLLLVVALALAQAGELSYGDRELIARGAKVTATVLVAAFLVRLIVVLSTRTYYALVVETSGNPLTLLASVDRDEVHQLVRDIMRAIEDPAFTGFVKQMVTYNIGSMRDFYNASGTGSVGRMGHDRER
>NZ_CP029196.1|WP_150161988.1|5439234_5440164_+|hypothetical-protein
MSIEPADYVARLRARANDPGREEALRRDRTERRRRIALAAGAGVLLLGGFGFWLADVTGERPPYEPYSPETLYEASWPREWPYSENMPFRDSPAFGWAEGADGIYVPQPMPSGEFTREEITAVLDDVKTLLVGTNLSEETLFGGSEPAAALALLDPRGAGDAVRKDLVTRFDPDEVYLHETGIRTRGTLTHELSAAGELVVRADYSFVYPLVSASAGREVLPGVPEVARISVRRQLTVTSRGGKLVLGAYASEVGNHDCSAPRDGYLHPLFAEGRWKAARAAEGPLVDPYGEKRVLPSGPGHCVAPTGT
>NZ_CP029196.1|WP_150161989.1|5440375_5442487_+|phospholipase-C,-phosphocholine-specific
MSSEKSPELSRRRLLALGGGAVGVATAGSLLPPSLQAAMAAEPPAGGMSAVRHVVILMQENRSFDHYFGTLRGVRGFSDRNAIELPSGKPVFEQPAALGRTVLPFPIRGAAETQRKDLQYIGDLDHSWGGGGKAWHGGWMDGWVSAKTAATMAYYDRQDIPLHHELADTFTICDAYHSSIHTSTSPNRNHLWSGWTGYEADGSRAVTNAAYAEDTHPGYGWPTYAERLEAAGRSWKTYTEWENFTDNNIEFFTRFKKIARKALAKTGGHTFMESFYAAVRDTEDLTERTRLLGLLEEGVATLTDAERSLFERGLRRVESGTLADAFRADVAAGTLPEVSYLVPSAIDSEHPGSSSPVASASLVYKVLDALGAHPDVWRHTVVLINYDENDGFFDHVPPPVPPADDPSGDAERWRGQPTGLGIRVPLLVVSPWSVGGYVCSETFDHTSVIRFLERLTGVREPNITPWRRTVTGDLTSAFDFRRPRRLPPVEQPGAVPPFTGRWRPQPPAVQRMPVQEPGVRPARPLPYQPDASATLAPGAVHVALSNRGKASAHFALYPYAGEFDLPQHRDVRGTGEWTVPVPGDHYRFTITGPNGFRREFEGPAAGGAELVSRIDHHDRDLHLTVRNTGPAAVFFTVRPLGYVDEDDLDDWTRTVKVKPGKTRTLVHSAADAHGWYDVEVTAPGGFRRRLMGHIENGRASVSG
>NZ_CP029196.1|WP_150161990.1|5442675_5444970_+|MMPL-family-transporter
MAAIARWCIRHRLVAVLLWLVALCGVGTAAALAGNAYSNDYEVPGTESGRATALLERGFHGLGGDSDTIVWHTDRGSVRADAVEKRMTAVLDQVADLPGIAAVTSPYGDTRGQVSEDGHTAYATVTFHEQADDIPEAQARALVDTAKAAEGDGLAVELGGSAVALTEAPGGHIAEIVGVAVAAVVLFLAFGSLAASVLPIATALVSVGIAYSGIALLGHLMTVADFAPMLGLLVGLGVGIDYALFIVTRHRRGLKRGLSVAEAAETAVATTGRAVVFAGATVCIALLGMLILRLSFLNGVAIAASLTVVLTVAASVTFLPALLSFIGMRALSRRERRALAEHGPQPELPTGFAARWSAFVERHPKLLGLAAVVVMGVLALPTLSLHLGTSDQGNGAATATTRKAYDLIADGFGPGVNGPLTLVAGLDGADDRVALDQLPAALSATKGVASVSPVTYNGSGDTAFLTVVPESSPQSKATSELVDRIRTDVLPEAGTGTSLQVHVGGVTASYDDFAEIIVGKLPLFVGVVIALGCLLLLLAFRSIGIPLKAAAMNVAAVAAAFGVVVAIFQWGWGSELLGLGSAGPIEPFLPVIMVSVLFGLSMDYQVFLVSRMYEEWLETGDNRRAVRVGLAETSRVINSAAVIMISVFLAFVLSGDRVIAMFGIALAAAVALDAFVLRTLLVPALMHLLGGANWWLPKWLDRLLPRLSIEPPECREAADFREAGVSPEAVVTRGKIPVQRVTAEAAAPAAAAEERNDDVRDTAG
>NZ_CP029196.1|WP_150161991.1|5444947_5445505_+|GNAT-family-N-acetyltransferase
MFAIPLGDDGAELRPLEPSNAEEFLAHMDRGRAFVGEHIVLADVVTDLDSARSFLRSYAEKAASDTGRIYGIWTDGTLVGGVLFRTFDAAHGIAEAGCWLEPSAAGKGLITRACRVIIDWAIEERGIHRVEWYASAKNEPSIAVARRLGMTREGVLREHYPHRGVRADTELWAVLAPEWRAAKTV
>NZ_CP029196.1|WP_150161992.1|5445553_5446156_+|hypothetical-protein
MDTKTTTEKTDEGADAPGTAEETAAVALDKQDTEPATAPIDADADAAGDEAGDTDRDDEDRDDEDEESAAEAAPAPAGIGGAAAAVVSAALGAVALTGTWTGKVVSERETLLGQIKTSGTGTPAQQISEIYGDAWHSTALVNGVFALIALLVAVLVLVLPGRPAWVRAVAVAGAVLGGLGLLLSVGTYFDLFLSLPTAGS

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Crispr_ID: NZ_CP029196_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_18

5438494-5438609

Orphan

Consensus_repeat	Method
GCGTTGTAGAAGTCGCGCATGCTGCCGATGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_18

>merge|NZ_CP029196|18|5438494-5438609|CRISPRCasFinder
GCGTTGTAGAAGTCGCGCATGCTGCCGATGTGGAAGTCACCGTTCCCGGTCATGGCCCATCCTCCCCACGCTGCCCGTGCCGGACGCGTTGTAGAAGTCCCGCATGCTGCCGATGT

>NZ_CP029196|18|14|5438494-5438609|CRISPRCasFinder
GCGTTGTAGAAGTCGCGCATGCTGCCGATGT	GGAAGTCACCGTTCCCGGTCATGGCCCATCCTCCCCACGCTGCCCGTGCCGGAC
GCGTTGTAGAAGTCCCGCATGCTGCCGATGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_015036350.1\|5430023_5430320_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP029196.1\|WP_150161978.1\|5427802_5429917_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP029196.1\|WP_150161989.1\|5440375_5442487_+\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NZ_CP029196.1\|WP_015036366.1\|5446304_5446502_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161979.1\|5430325_5431822_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP029196.1\|WP_150161981.1\|5433680_5435396_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378342
NZ_CP029196.1\|WP_150161994.1\|5449616_5450759_-\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP029196.1\|WP_150163726.1\|5451985_5452924_+\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240643
NZ_CP029196.1\|WP_150161991.1\|5444947_5445505_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP029196.1\|WP_150161995.1\|5450860_5451883_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NZ_CP029196.1\|WP_150161990.1\|5442675_5444970_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP029196.1\|WP_150161988.1\|5439234_5440164_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161984.1\|5436667_5437093_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP029196.1\|WP_150161992.1\|5445553_5446156_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161980.1\|5432077_5433589_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP029196.1\|WP_150161982.1\|5435487_5435730_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP029196.1\|WP_150161985.1\|5437191_5438205_+\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176189
NZ_CP029196.1\|WP_150161993.1\|5446509_5449560_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226415
NZ_CP029196.1\|WP_041662892.1\|5431827_5432061_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150161983.1\|5435726_5436554_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|213767

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015036350.1\|5430023_5430320_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	2.20028e-37
NZ_CP029196.1\|WP_150161978.1\|5427802_5429917_+\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.35942e-103
NZ_CP029196.1\|WP_150161989.1\|5440375_5442487_+\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NZ_CP029196.1\|WP_150161979.1\|5430325_5431822_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP029196.1\|WP_150161981.1\|5433680_5435396_-\|hypothetical-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	2.55232e-22
NZ_CP029196.1\|WP_150161994.1\|5449616_5450759_-\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	1.3815e-77
NZ_CP029196.1\|WP_150163726.1\|5451985_5452924_+\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240643	cd12166, 2-Hacid_dh_7, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.55411e-144
NZ_CP029196.1\|WP_150161991.1\|5444947_5445505_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	9.60572e-25
NZ_CP029196.1\|WP_150161995.1\|5450860_5451883_-\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	7.91906e-126
NZ_CP029196.1\|WP_150161990.1\|5442675_5444970_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	6.52887e-94
NZ_CP029196.1\|WP_150161984.1\|5436667_5437093_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	4.24362e-20
NZ_CP029196.1\|WP_150161980.1\|5432077_5433589_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP029196.1\|WP_150161982.1\|5435487_5435730_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.32859e-17
NZ_CP029196.1\|WP_150161985.1\|5437191_5438205_+\|zinc-binding-dehydrogenase	gnl\|CDD\|176189	cd05286, QOR2, Quinone oxidoreductase (QOR). Quinone oxidoreductase (QOR) and 2-haloacrylate reductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. 2-haloacrylate reductase, a member of this subgroup, catalyzes the NADPH-dependent reduction of a carbon-carbon double bond in organohalogen compounds. Although similar to QOR, Burkholderia 2-haloacrylate reductase does not act on the quinones 1,4-benzoquinone and 1,4-naphthoquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	5.80765e-171
NZ_CP029196.1\|WP_150161993.1\|5446509_5449560_+\|AAA-family-ATPase	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.69495e-39
NZ_CP029196.1\|WP_150161983.1\|5435726_5436554_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	8.35815e-06

>NZ_CP029196.1|WP_150161985.1|5437191_5438205_+|zinc-binding-dehydrogenase
MRAIQVYEVGGPEVLREAEVDPPRPGPGEAVVEVAASGVNFLDVYHREGRYTLPLPFTPGAEGAGTVVEVGPGVTDVAVGDRVGWVEIPGTYAERAVVDASRLVPLPDDIDFETAAAVLLQGMTAHYLIKDAYPVQGGDTVLVHAAAGGMGLLLTQLITHLGGRVIGTTSTAAKAELAKRAGAAEVILSSAVDDLAAEVRRLGGGQGLPVVFDGVGAHTFDASLASLRPRGHLVLFGAASGAVPPFDPIRLAHGGSLTLIRPSLGDFIADRSELLRRAADVFEWVRSKALEVTVTGRYGLSEAAQAHSDLEARRTTGKLLVIPGAAADLPGLPGRSG
>NZ_CP029196.1|WP_150161984.1|5436667_5437093_+|ATP-binding-protein
MSDELPLFREAFYRRERRSVPLARDFARKALADWGLDARADDVLVCVSELATNALRHGVPPGRGYRLHLYLERPGPLRVEVHDSGDGTPAVREPSGESGRGLLLVGALADRWGVGARRPGKIVWCEFAPAEGGPEAFPDSP
>NZ_CP029196.1|WP_150161983.1|5435726_5436554_-|helix-turn-helix-domain-containing-protein
MQRGTNSRKKVPSWEVVGALVALYRKQAGLTQPQLAAQACVGLETLGSIEQGRRALRLGLAGELDGILSTGGALAVAVGKAPKKERYPAFAQEFIELEAQALSLCSYENAVVPGLLQTPEYARAVLDCLYPPITPQEAEDRMLDRLDRQRIFEQTPWPPMMSFLLDESILEKTIGGREVLRGQILHLREMAELPFLGLQIIPKSRTTHAGLDGPMVLLETPDHEHVAYIEGQRVSFLIDDPDEVGILQAKYGMLRSQALTPEDTMGLLERLAGVT
>NZ_CP029196.1|WP_150161982.1|5435487_5435730_-|DUF397-domain-containing-protein
MSAAALSWFKSSYSGSEGGNCLEVAYDWRKSSYSGSEGGACVEVAAHPAAVHVRDSKLGATSPVFTVSPTAWDAFVGATS
>NZ_CP029196.1|WP_150161981.1|5433680_5435396_-|hypothetical-protein
MCLVPVIRSSSPLSRRAARAGAVLLVASSLQLTTPATAEPTPDHPALGAVFPLGDHSAPKTGSKELAPGVTYRVFTQGAANDVWTVWVRYDDGQEVTTGRTTATALAEKLRTAGYGDARVVPLDSPATADTYAQTFYGVHVGSYATATEAKALQEELKTKGFADSRTLYTAETNADSRGPWQIRVITVRPDAQVDLRTEHGTTVSGSETVRQLSAAAGALAAVNGTEFDIDSVNNTAFMGHEGVPQGLYMKNNVLLGSSNNGRTALLLNAAGGGHRITEVKSRTWITAPDGTERDVDGINRVAGQILGCGGVGDDFRKTASLGNVPRLDPWRNGICYDPNEIVVFRPEWGTTTPAPAKEWAGTPVTEVVTNGNWDVLFLRDAPGPIPAGGRVLQGIGKGREWLRTLKPGDRVTPHTTVTDTAGTPVTAPALSAVGAGTPALMRDGQVWLNPAANGMAHVACVLPAPATGCRPSGALTARHPRTLAGISPEGHLMLVTIDGRNPGTSVGVTLPEAARVMEWLGARDAVGLGSGGDTTLMVENTLYNRPRDQWSDTASHERAVSNAVVVVPRS
>NZ_CP029196.1|WP_150161980.1|5432077_5433589_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTVTELLSYEAALAEYDPVMGLEVHVELGTKTKMFCGCSTELGAEPNSQTCPTCLGLPGSLPVVNAIGVESAIKIGLALHCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFNGYLDVQLEDGEVFRVEIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGIPLIEIVTKPIEGAGERAPEVAKAYVAELRELIRALGVSEARMDKGQMRCDVNLSLRPHGTKTFGTRSETKNVNSLRSVERAARFEIQRHAAVLSSGGSIVQETRHFHEDDGSTTSGRIKDNAEDYRYFPEPDLVPVAPAREWVEELRGGLPELPRVRRNRLREEWAVSEQEMQSILNAGAVDAIVATTEAGADAASARKWWMGELARNANEKGVSLEELPITPADVARVSALVAGGDLNDKLARQVIEGVLAGEGTPDEVVEKRGLKVVSDDGALGAAVEEAIAGNAAIADKIRGGKVAAVGALVGAVMKATRGQADAAKVKDLILEKLGVSEG
>NZ_CP029196.1|WP_041662892.1|5431827_5432061_+|hypothetical-protein
MAKKAKNFKKSKTGVYVSLATTAFGAISVAKQAKLARNDHDMLRLIDSAVSAAAIVTGLAILYRELKRLGDDDVLLG
>NZ_CP029196.1|WP_150161979.1|5430325_5431822_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MTDNIIKLTAAEIAGKIAAGELTAVEVTEAHLARIEAVDEKVHAFLHVDREGALAQARAVDEKRARGEKLGPLAGVPLALKDIFTTAGMPTTVGSKMLEGWIPPYDATLVKNLKAADVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTRIPGGSGGGSSAALAAYEAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGGVSRYGMVAFSSSLDQGGPCARTVLDAALLHEAIAGHDPLDSTSIDAPVPPVVEAARNGSVAGMRVGVVKQFRGEGYQAGVVQRFDESVELLKSLGAEIVELDCPTFDLALSAYYLIAPSECSSNLARFDAMRYGLRVGDDGTRSAEDVTALTREAGFGDEVKRRIILGTYALSSGYYDAYYGSAQKVRTLITREFEKAFEDVDVIVSPTTPTTAFPIGERADDPMAMYLADLCTIPTNLAGNAAMSLPCGLAPEDGLPVGLQIIAPAMKDDRLYKVGAAVEAAFVEKWGHPLLEEAPSL
>NZ_CP029196.1|WP_015036350.1|5430023_5430320_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPGITREEVAHLARLARLELKGEELDHFAGQLDDIIGAVARVSEVADQDVPPTSHPLPLTNVMRADEVRPSLTPEQALSGAPAQEQQRFKVPQILGED
>NZ_CP029196.1|WP_150161978.1|5427802_5429917_+|EAL-domain-containing-protein
MEPTESAAPVPRPHGRVSPEGFTSRLPAAVVGIAAVVLVAGLQQALTTGHGLFPDGVTGWSLAVLTGLIVGHLVALGRDRWWGGTGSGAALTLAVLLLYGWVPAGLVSMTVVALVGAARRHRWRQGVLHGAADVLGVAVAALVLALFGDVPTVEQPWQPLDWTIGDLPEVVLAAATYLVVTRLLLWYTLAPQGRGLPTVARTALLRQGLVAVALLGIAPLICVVAASSPVLLPLFAVPLIALDSTLWIARARAEEQLRDPLTGLPNRQWLLERAWTALEEAEGEGARAALVLIDLDRFRSVNDTLGHLAGDRLLLQIAERLRLALPRGAEAARLGGDEFAVLLPTADSTTSAQRVARHLVAELSSPLDLDGLTLVLEASAGVAVFPDHALDAEGLLRRADVAMYQAKRDRTGVEVYESKRDSNTPDRLGLLGDLRRALDAGEVELHYQPKVQFDGQVAGLEALVRWVHPERGKVPPDEFIAIAESSGLMPHLTEYVLETALAQVARWRAQGLNVPVAVNVSPRDVHTPGFAGAVAARLARHGVPAGALQLEITEHVLLEDPQRAADTLNGLTGHGVKMSLDDFGTGYSSLVHLRRLPVSELKIDRSFVARLAVDTEDAEIVRCTVDLAHSLGLLVVAEGVEDDETWERLRDLGCDAVQGWLVAAAMPPGEATAWLLARGEHGWRRPADIAAELAVDHPSGQVVQ
>NZ_CP029196.1|WP_150161988.1|5439234_5440164_+|hypothetical-protein
MSIEPADYVARLRARANDPGREEALRRDRTERRRRIALAAGAGVLLLGGFGFWLADVTGERPPYEPYSPETLYEASWPREWPYSENMPFRDSPAFGWAEGADGIYVPQPMPSGEFTREEITAVLDDVKTLLVGTNLSEETLFGGSEPAAALALLDPRGAGDAVRKDLVTRFDPDEVYLHETGIRTRGTLTHELSAAGELVVRADYSFVYPLVSASAGREVLPGVPEVARISVRRQLTVTSRGGKLVLGAYASEVGNHDCSAPRDGYLHPLFAEGRWKAARAAEGPLVDPYGEKRVLPSGPGHCVAPTGT
>NZ_CP029196.1|WP_150161989.1|5440375_5442487_+|phospholipase-C,-phosphocholine-specific
MSSEKSPELSRRRLLALGGGAVGVATAGSLLPPSLQAAMAAEPPAGGMSAVRHVVILMQENRSFDHYFGTLRGVRGFSDRNAIELPSGKPVFEQPAALGRTVLPFPIRGAAETQRKDLQYIGDLDHSWGGGGKAWHGGWMDGWVSAKTAATMAYYDRQDIPLHHELADTFTICDAYHSSIHTSTSPNRNHLWSGWTGYEADGSRAVTNAAYAEDTHPGYGWPTYAERLEAAGRSWKTYTEWENFTDNNIEFFTRFKKIARKALAKTGGHTFMESFYAAVRDTEDLTERTRLLGLLEEGVATLTDAERSLFERGLRRVESGTLADAFRADVAAGTLPEVSYLVPSAIDSEHPGSSSPVASASLVYKVLDALGAHPDVWRHTVVLINYDENDGFFDHVPPPVPPADDPSGDAERWRGQPTGLGIRVPLLVVSPWSVGGYVCSETFDHTSVIRFLERLTGVREPNITPWRRTVTGDLTSAFDFRRPRRLPPVEQPGAVPPFTGRWRPQPPAVQRMPVQEPGVRPARPLPYQPDASATLAPGAVHVALSNRGKASAHFALYPYAGEFDLPQHRDVRGTGEWTVPVPGDHYRFTITGPNGFRREFEGPAAGGAELVSRIDHHDRDLHLTVRNTGPAAVFFTVRPLGYVDEDDLDDWTRTVKVKPGKTRTLVHSAADAHGWYDVEVTAPGGFRRRLMGHIENGRASVSG
>NZ_CP029196.1|WP_150161990.1|5442675_5444970_+|MMPL-family-transporter
MAAIARWCIRHRLVAVLLWLVALCGVGTAAALAGNAYSNDYEVPGTESGRATALLERGFHGLGGDSDTIVWHTDRGSVRADAVEKRMTAVLDQVADLPGIAAVTSPYGDTRGQVSEDGHTAYATVTFHEQADDIPEAQARALVDTAKAAEGDGLAVELGGSAVALTEAPGGHIAEIVGVAVAAVVLFLAFGSLAASVLPIATALVSVGIAYSGIALLGHLMTVADFAPMLGLLVGLGVGIDYALFIVTRHRRGLKRGLSVAEAAETAVATTGRAVVFAGATVCIALLGMLILRLSFLNGVAIAASLTVVLTVAASVTFLPALLSFIGMRALSRRERRALAEHGPQPELPTGFAARWSAFVERHPKLLGLAAVVVMGVLALPTLSLHLGTSDQGNGAATATTRKAYDLIADGFGPGVNGPLTLVAGLDGADDRVALDQLPAALSATKGVASVSPVTYNGSGDTAFLTVVPESSPQSKATSELVDRIRTDVLPEAGTGTSLQVHVGGVTASYDDFAEIIVGKLPLFVGVVIALGCLLLLLAFRSIGIPLKAAAMNVAAVAAAFGVVVAIFQWGWGSELLGLGSAGPIEPFLPVIMVSVLFGLSMDYQVFLVSRMYEEWLETGDNRRAVRVGLAETSRVINSAAVIMISVFLAFVLSGDRVIAMFGIALAAAVALDAFVLRTLLVPALMHLLGGANWWLPKWLDRLLPRLSIEPPECREAADFREAGVSPEAVVTRGKIPVQRVTAEAAAPAAAAEERNDDVRDTAG
>NZ_CP029196.1|WP_150161991.1|5444947_5445505_+|GNAT-family-N-acetyltransferase
MFAIPLGDDGAELRPLEPSNAEEFLAHMDRGRAFVGEHIVLADVVTDLDSARSFLRSYAEKAASDTGRIYGIWTDGTLVGGVLFRTFDAAHGIAEAGCWLEPSAAGKGLITRACRVIIDWAIEERGIHRVEWYASAKNEPSIAVARRLGMTREGVLREHYPHRGVRADTELWAVLAPEWRAAKTV
>NZ_CP029196.1|WP_150161992.1|5445553_5446156_+|hypothetical-protein
MDTKTTTEKTDEGADAPGTAEETAAVALDKQDTEPATAPIDADADAAGDEAGDTDRDDEDRDDEDEESAAEAAPAPAGIGGAAAAVVSAALGAVALTGTWTGKVVSERETLLGQIKTSGTGTPAQQISEIYGDAWHSTALVNGVFALIALLVAVLVLVLPGRPAWVRAVAVAGAVLGGLGLLLSVGTYFDLFLSLPTAGS
>NZ_CP029196.1|WP_015036366.1|5446304_5446502_+|hypothetical-protein
MFEYELHRMNHAQLVREAAAERLAHQAAETAGATRGLRRLGRRGGGQDPEGRVNDGGRGRFVRAA
>NZ_CP029196.1|WP_150161993.1|5446509_5449560_+|AAA-family-ATPase
MSAHADLCAMLGAVETRSVSPVFVGRAGELTALTEALSRATAGEPQALLIGGEAGVGKTRLIEEFLDAACERGAVVALGGCVELGADGLPFAPFATALRSLHRRLPGELLAAAHGHEAELARLLPELGDPGGQDSSDEDSTARLFELTVRLLERLAADRTIVLVLEDLHWADASTRHLLTYLLRTLRRGRIAVVASYRADDIHRRHPLRPLLAELDRLRTIRRIELARFSRTEVHRQLTGILAAEPDPGLVDEVFQRSDGNAFFVEELVVSHEAGCAAGQLSDSLRDLLLVRVETLPEDAQRVARIVAEGGSTVEYGLLAAVARLSEDDLIEALRAAVGANILLAAPDGDGYRFRHSLVREAVSDDLLPGERSRLNRRYAEALEADPTLVRADERANRLATYWYHAHDPAKALPAVLGASVATRKRHAYAEQLSLLERAMELWDKAPAETRDSLRPLDYADAYPACGCDPDTTSLRFLDLLAEAAVAARLSGERERAAKICRTALRILDDENDPLRAAWFWTETARLQSNLGRGDGWPEIARAQELVKGLPPSAVHATVLVGAAGWGMLRNPGPEALAAAERAVEYARFVKNEPIELNARITLGTIMVSAGDTEGGLAALHQARERTIALGQFHEATRAHINISSSLEALGRSREAVEIATTGIDLARSRGLVDSAGWIRANLSESLLSLGEWDRSKEEAEELLRSGASSTKPGGTALLQLAHLAAARGEPARAAEHLAEARTRYGTRDPIPQYTLPMAQVEIAIAAAEGRLADVRHQLAAMADAGFPPGTHRYGWPLVLTAVTAEADSRGLPAADEGRAEALDVVRRCVRGLAVQAPVWEAYSLQVSEELARAEGRDTAARWAEVVAAYEPVERPYQLARARHRLADALLVEGGRREEATALLREAHATAVRLGARPLREDVELLAARARLSLAAEKPPVAAEPGDDTFGLTPREQAVLGLVAAGRTNRQIAEELFISPKTASVHVSNILAKLGVSGRGEAAALAHRLHLLDPAL
>NZ_CP029196.1|WP_150161994.1|5449616_5450759_-|PQQ-dependent-sugar-dehydrogenase
MSRPAVVKALWGAAVLVLVAGCSSGGTEDRPGTAPPTSPPVTATASAGPSGSASAPAGGRVAVAGTLTEGLRSPWGLAELPGGDLLVSSRDERTITRIDGRTGAKTPLGEVPGVVPGGEGGLMGLAVRDGWVYAYLTAESDNRIVRMRYGGGDGDRLGAPQPVLTGIPKGLVHNGGRIAFGPDRMLYAGTGETGRTGLAQDRESLGGKILRMTPEGRPAPGNPFAGSVVYSYGHRNVQGIAWDDEGRLWAAEFGQNTWDELNLVEPGKNYGWPEAEGRAGEARFVDPVAQWPTSEASPSGIAYARGAIWMAGLRGQRLWRVPLSGAERSGDPGAFLSEEYGRLRTVLAGGGGRLWLVTSETDGRGTPGPGDDRILRLEVS
>NZ_CP029196.1|WP_150161995.1|5450860_5451883_-|aldo/keto-reductase
MERRTIGATALDVGAIGLGCMPMSWAYSRSEQRGDRSLRTVHAALDAGVSLLDTADMYGPFTNELLVGRVLKERRADVFVSTKCGLLVGDGGERRHVVANGRPGYVRRACDASLRRLQTDVIDLYQLHRADPEVPVEETWGAMAELVSVGKVRALGLCAVGARSARRGATGVGRDGYEGTIRQLERIQQVFPVAAVQAELSVWSQEALVRLLPWCVARGVGFLAAMPLGNGFLTGTLTPGGGFEPDDPRARHPRFTAEMMAANQPLVAGLRRVAARHGAEVTPAQVALAWVLGRGRHVVPVPGAKRERWAVENAGAAGLRLTSADLAEIAALPAPRGSWD
>NZ_CP029196.1|WP_150163726.1|5451985_5452924_+|2-hydroxyacid-dehydrogenase
MWLPIPADEIDDLPDPGESGLNYRFWDGGPEFPADPARCAFFVVPYMKGPEIAVRPLAAMTSVRIVQTLSAGIDHVTPGIDALPPGVALCNAKGVHEASTAELTLALILASLRGIPGFVRGQDAEEWRAGFYPALADKSVLIVGYGSIGAAIEDRLAPFECARVVRVARSARTTARGPVHPLAELPALLPQADVVVLSTPLTPETRHLADAGFLARMKDGALLVNVARGPVVDTAALLKEVETGRITAALDVTDPEPLPAGHPLWHAPGVLVSPHVGGSTSAFMPRAKRLIAGQLRRFAAGEEPVNVLLTTT

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Crispr_ID: NZ_CP029196_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_19

5776411-5776500

Orphan

Consensus_repeat	Method
CCGGCCTGCGGCCGCGTCGGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_19

>merge|NZ_CP029196|19|5776411-5776500|CRISPRCasFinder
CCGCCCGGCGTCCTCCTGGGCCTCCCGACCATCGGCGCCCCGGCCCCCCTCCCGGCAGCCGAGGTCCCGGCCTGCGGCAGCCACTGAGCC

>NZ_CP029196|19|15|5776411-5776500|CRISPRCasFinder
CCGCCCGGCGTCCTCCTGGGCCT	CCCGACCATCGGCGCCCCGGCCCCCCTCCCGGCAGCCGAGGTC
CCGGCCTGCGGCAGCCACTGAGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150162146.1\|5781540_5783958_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|223394
NZ_CP029196.1\|WP_150162142.1\|5776930_5777668_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153388
NZ_CP029196.1\|WP_150162137.1\|5768975_5770292_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NZ_CP029196.1\|WP_106433750.1\|5778166_5778316_-\|gliding-motility-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162144.1\|5778320_5778653_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240291
NZ_CP029196.1\|WP_150162138.1\|5770372_5770789_-\|Ohr-family-peroxiredoxin	unknown	unknown	gnl\|CDD\|274649
NZ_CP029196.1\|WP_150163736.1\|5772691_5773840_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP029196.1\|WP_150162133.1\|5763386_5764187_+\|hydantoin-racemase	unknown	unknown	gnl\|CDD\|226611
NZ_CP029196.1\|WP_150162145.1\|5780470_5781340_+\|diaminopimelate-epimerase	unknown	unknown	gnl\|CDD\|234768
NZ_CP029196.1\|WP_150162139.1\|5770940_5772029_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP029196.1\|WP_150163735.1\|5772056_5772695_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP029196.1\|WP_150162135.1\|5765335_5766802_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NZ_CP029196.1\|WP_150162140.1\|5774090_5774756_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP029196.1\|WP_150162148.1\|5786165_5787659_+\|GTPase-HflX	unknown	unknown	gnl\|CDD\|225171
NZ_CP029196.1\|WP_150162136.1\|5766798_5768979_+\|acetyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|223972
NZ_CP029196.1\|WP_150162134.1\|5764311_5765331_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NZ_CP029196.1\|WP_150162143.1\|5777781_5778114_-\|antitoxin	unknown	unknown	gnl\|CDD\|379416
NZ_CP029196.1\|WP_015036648.1\|5778689_5779628_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_CP029196.1\|WP_150163737.1\|5779856_5780249_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162147.1\|5784528_5786019_+\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150162146.1\|5781540_5783958_+\|HD-domain-containing-protein	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	5.84093e-119
NZ_CP029196.1\|WP_150162142.1\|5776930_5777668_+\|hypothetical-protein	gnl\|CDD\|153388	cd07951, ED_3B_N_AMMECR1, The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain. This subfamily is composed of uncharacterized proteins containing an N-terminal domain with similarity to the catalytic B subunit of class III extradiol dioxygenases and a C-terminal AMMECR1-like domain. This model represents the N-terminal domain. Class III extradiol dioxygenases use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon, however, proteins in this subfamily do not contain a potential metal binding site and may not exhibit class III extradiol dioxygenase-like activity. The AMMECR1 protein was proposed to be a regulatory factor that is potentially involved in the development of AMME contiguous gene deletion syndrome.	7.44783e-56
NZ_CP029196.1\|WP_150162137.1\|5768975_5770292_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NZ_CP029196.1\|WP_015036648.1\|5778689_5779628_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	5.19213e-147
NZ_CP029196.1\|WP_150162144.1\|5778320_5778653_-\|hypothetical-protein	gnl\|CDD\|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	8.54958e-06
NZ_CP029196.1\|WP_150162138.1\|5770372_5770789_-\|Ohr-family-peroxiredoxin	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	1.36452e-62
NZ_CP029196.1\|WP_150163736.1\|5772691_5773840_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.17966e-36
NZ_CP029196.1\|WP_150162133.1\|5763386_5764187_+\|hydantoin-racemase	gnl\|CDD\|226611	COG4126, COG4126, Hydantoin racemase [Amino acid transport and metabolism].	2.08011e-17
NZ_CP029196.1\|WP_150162145.1\|5780470_5781340_+\|diaminopimelate-epimerase	gnl\|CDD\|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	1.06554e-103
NZ_CP029196.1\|WP_150162139.1\|5770940_5772029_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	1.15354e-95
NZ_CP029196.1\|WP_150163735.1\|5772056_5772695_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.50439e-37
NZ_CP029196.1\|WP_150162135.1\|5765335_5766802_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	1.91458e-133
NZ_CP029196.1\|WP_150162140.1\|5774090_5774756_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.96295e-42
NZ_CP029196.1\|WP_150162148.1\|5786165_5787659_+\|GTPase-HflX	gnl\|CDD\|225171	COG2262, HflX, GTPases [General function prediction only].	3.1255e-170
NZ_CP029196.1\|WP_150162136.1\|5766798_5768979_+\|acetyl-CoA-synthetase	gnl\|CDD\|223972	COG1042, COG1042, Acyl-CoA synthetase (NDP forming) [Energy production and conversion].	8.05773e-128
NZ_CP029196.1\|WP_150162134.1\|5764311_5765331_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NZ_CP029196.1\|WP_150162143.1\|5777781_5778114_-\|antitoxin	gnl\|CDD\|379416	pfam14013, MT0933_antitox, MT0933-like antitoxin protein. This family of proteins contains the MT0933 protein, which has been identified as an antitoxin to /protein MT0934. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	4.62588e-16
NZ_CP029196.1\|WP_150162147.1\|5784528_5786019_+\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.13836e-141

>NZ_CP029196.1|WP_150162140.1|5774090_5774756_-|DedA-family-protein
MNLTTMALAQQPADGIAGWAAGLVDTMGGPGAGLAIALENLFPPLPSEIILPLTGFAAGQGVLSLTSALFWTTLGSVAGAVALYWIGALFGRERMHAIWGRLPLVKASDLVRTEEWFARHGGKAVFLGRMVPVFRSLISVPAGVERMPMPRFIMLTTLGSLVWNSVLVVAGYALGDRWDVVESYVGVLSKAVVALVGVACAAYVAVRLRGRGRGAQHRRTS
>NZ_CP029196.1|WP_150163736.1|5772691_5773840_-|sensor-histidine-kinase
MPRLRRGLPRLRRGLGTVFGCVTAAAGALHFLVGGLALGPFLLWPRTRAGALDLLTGGVRRLAALERARRSVFFGDVFPEHYRAADRKVLRYLAVRSYAGLLCALVLGLLVFGAVLAGILGYGVLRGTIGWDELLTQVLLGGVLLFLDVQGLYALAALDARTARECFGPSERELLRRRIEELAASRAAVVEAVDAERRRIERDLHDGVQQRLVALGMLIGRARRGRDPERAGALLLQAHEESRGVLAELREVAWRAYPSALDSLGLEEALGGVAERCALPLRLRFEVAGPLPRAVETAAYFVVSECVTNAAKHSAASAVSVSVAREGALLTVRVEDDGSGGANENGGGLTGLRSRVAALDGVLRVHSPLGGPTTVTAELPCA
>NZ_CP029196.1|WP_150163735.1|5772056_5772695_-|response-regulator
MILAEDSTLLREGLVRLLAEEGHEVLAALGDAVTLVREVGEQRPDLVVVDIRMPPTHTDEGLRAAVEIRRRWPGVGVLVLSQYVERPYAAELLAAGAERVGYLLKDRVAQVEEFLDALERIHAGGAAIDPEVVRQLVVRTTHGDPLARLTPRERTVLEALAQGHTNTAIAAKLHLSLSSVEKNLNAVFDKLELTRATGYSRRILAVLRYLEA
>NZ_CP029196.1|WP_150162139.1|5770940_5772029_+|CoA-transferase
MAGPLTGVRVLEFAGSAPTAFVGTVLSGLGADVVRVDRAPGAAPGPGARPAENPLSRGRRSVALDLKTPAGVEEALALAEHADILVEGFRPGVAERLGIGPDAARARNPRLVYGRVSGWGQQGEWAGRAAHDLAVLALTGALDTDPATGDPVLPPTAYLSSFAGGASVHVQALLAALHERERSGLGQVVDTALADGAALISTLIHQWREVPGNHTVTDAPHYSLYRAADGRHLAVAAIEPKLYQNLLEQLGLADTDDLPDRTDPADWPALRALIADRFASRDRDHWAKVFDAVDAGVAPVLTAAEAAGHHQLAARGAFVTVGDSTVPQPAPPSRFDRTPAVPPSRAPLPGEHTDEVLAEWRR
>NZ_CP029196.1|WP_150162138.1|5770372_5770789_-|Ohr-family-peroxiredoxin
MAVVYTAEVISTGDGRNGAVRSSDGLLDLPLSSPKAVGGSGTATNPEQLFAAGYAACFHSALRVSAREAKVALADDTVVAEVALHKEESGFRLSVVLTVELPGIDESEARRLAEAAHGRCPYSKAVRGNVEVRVDIAP
>NZ_CP029196.1|WP_150162137.1|5768975_5770292_+|glutamate-1-semialdehyde-2,1-aminomutase
MSGVGTGGGGTASKALFERAREVTPGGVNSPVRAFGAVGGTPPFMASAQGPYLTDADGNEYVDLICSWGPMILGHRHPAVVEAVTGALALGTSFGAPSTGEVELAEEIVDRVDPVEQVRLVSSGTEATMSAIRLARGFTGRGKIVKFAGCYHGHVDALLASAGSGLATFALPDTPGVTGAQASDTIVLPYNDLAAVEKVFAEIGDEIAAVITEAAPGNMGAVPPLPGFNAGLKDVTSRHGALFISDEVMTGFRASRSGWYGRDGVAPDLLTFGKVMGGGFPAAAFGGRADVMAHLAPAGPVYQAGTLSGNPVATAAGLATLRHSTPEVYERLDEVSATLGREVSAALTKEGVAHRVQYSGTMFSVFFTEDEVTDFDGVRATESYRYPPFFHELLRRGVYLPPSPFEAWFVSAAHDDRAVGRVVEALPAAAAAAASAKP
>NZ_CP029196.1|WP_150162136.1|5766798_5768979_+|acetyl-CoA-synthetase
MSDISALWEAESIAVIGASERPGALGRKPLDYLLRYGYKGRILPVNPRSPEILGVPAYPSVKDAPGPVDLALIMVSAERVLGAVDDCVAAGVKLAVIASSGFAETGEEGARLQAEVVAKARAGGLRIIGPNCIGAVGYENRVLATFSPLFGAESVPFEPGTLAFVSQSGALGFGAASLALERGLRPGWVVSTGNDADVTALEVLRELAAVPDVTGLLGYLEDTPDIDTLRALAGSGKPVALLKSGRTEAGGRAAASHTGALATDDRVLDAALRGLGVVRVDDIDELLDVARVFESERRPAGNRVAVVTTSGGSGILAADAVEAHGLQLSTLEPRSKEALAEIVPAFGAIDNPVDITATVLSDPSLFDRSLDVLIADDTVDIIVAAFCVMAGPDVEKAVNALSRAAAKGGKPILVARTGADFLAPDAPRDLREAGLPEYPTPARALRAAAALWEVSRPRTLPDAPRPGTVPGPGAQATEPELKRLLAEAGIPVPKGRIAENAEDAVRAVTEVGGTAVFKAVVPGLLHKTEAGGVEIGVTTAGAPAAYARLAALGGQVLVEELVGEGVELIVGVHTTDLGPVLTAGLGGIFTEVLDDVGHRLLPLAPGEGAELLAALRGAKILAGARGRAAVDVDAAAELLHKVAELAQGWPAGYALDLNPVRVLPKGAVVLDAALGIETATGDETAPGAETTPGEETVPGGDAASGAETASGAETASGLAAAEGAAR
>NZ_CP029196.1|WP_150162135.1|5765335_5766802_+|glutamyl-tRNA-reductase
MSPSSTMLVLGISHASAPLDLLERLAGTDRPAEDLVADVTSVDGIDAAVVVSTCNRLEIYAETRDDGAGPGAAGELTGLGELFAQHTGVDHEEIAPHLYSHHADGAVRHLFAVASGLESVVVGEDQILGQVKLGLERSQRLDRTGRVLAKAVQTALRVGKRARNETGLNEAGRSLATAGLGFFERRVGSLHGKTALVIGAGAFAGVVVAALRRSGLDRVHVANRTPEKAQRLAETTGGVGYDLADVPRLLTEVDVVVGATAATGHLVTAGQVEQALAARDGRELFLLDLSLPHNIAPAAAALPGVTFVDLRRIAEEGQEDEISAASVQAAHELIDAEVEQFRTGLRLAGATPVLTALRTAATEAAQVELDRLARRLEGVDGTVRREIDRSVRRIVDKALHQPTVLVRELAADPDGARHIAAFTRLFAAAEAEGGAGSTTPNGPNPPSAQNDPHAKSDPHANSDPHAKNDPHAKNDPNAQNETKIEAIA
>NZ_CP029196.1|WP_150162134.1|5764311_5765331_+|porphobilinogen-synthase
MTYDAYGRNTAATDPAAPYYRPRRLRRTPALRRFAAETRVGPANLVQPLFLREGLTEAREIPSMPGVLQHTRDTLRKAATEAVANGVGGLILFGIPEHKDPTGTGAIDPDGILQVALRDVVAEVGDSTVIIGDINLDEYTDHGHTGVLDAHGDVDNDASIELYAQAAVVQADAGAQIVAPSGMMDGQVRRIREALDQAGHQSVAILGYSAKYASHFYGPFRDAVESTLRGDRKGYQQFPGNIRESLLEVSLDVAEGADLVMVKPALAYLDIVRLIADHVQVPVAAYQVSGEYSMVEAAAAKGWIDRDQVVRESLASIHRAGATQIITYWASEFAQTLDR
>NZ_CP029196.1|WP_150162133.1|5763386_5764187_+|hydantoin-racemase
MRIWFHKHTVEGRLPLLDQWYREHLDAIAAPGTTVDIKTLPADTYPDRTPFGLVGHHSAQVLFSRHFSESALVAEREGYDAWVIAAGQDPGLRDARHLASIPTLGYGETAFFLSALTGQRFGVLGFMPPLEEPIRANIRQYRLEASLSSYEVVPGGWDSVHRSLEGDFDEFVEVYSAAAERAAKAGAEVIIPAEGIPNEILWHLGIHELHGLPVVDPAGLAVKLAETLVRLGELKLFQRSGHGYWFSRPDEPVAKHLEKVFLGEAL
>NZ_CP029196.1|WP_150162142.1|5776930_5777668_+|hypothetical-protein
MLVAAAVCPSPPLLVPEVATGAAPELDAARAACLDAVGLLAAARPDRLYVVGPAPEGAHGVYPAGSAGSFEGFGVDLSVRLGDDASEDERPDGRPVEDRPLPASLAVAAWLLGRAAWADAPIEGLGVDGAATPDVCAGLGRGLAEAADRVALLVMGDGSACRTVKAPGYLDERAEGFDAAAARALGTADAAALLALDPELAFELKVAGRAPWQVLAGAAEGAGLDGRLLFEDAPYGVGYFVAAWS
>NZ_CP029196.1|WP_150162143.1|5777781_5778114_-|antitoxin
MGLLDSLKAKLAPAKDKVADLAQQHGDKIDHGIDKAARLVDEKTKGKYSDKIHSGTDKAKDALDRIGHKDDGTPGTGTPGGGTPGTGTPGTGTPGTGTPGSGGTTPPPTV
>NZ_CP029196.1|WP_106433750.1|5778166_5778316_-|gliding-motility-protein
MEDEEADGVDAVDTDEAVAGAVATETVEIPKQQSADAAADNEAGEGART
>NZ_CP029196.1|WP_150162144.1|5778320_5778653_-|hypothetical-protein
MSYVTGLIRLRCLLRGSGRRSLRNPSHPSTLWSEYGRFCSVSPEEEGCGRGHGLCGGDRGRRSGRRSGRRRRRGRGGRPGGRDPVRGGGRGGRRRRGGGAGREHGRGPER
>NZ_CP029196.1|WP_015036648.1|5778689_5779628_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MRSAAPAPRVIAVVGPTAAGKSDLGVFLAQQLGGEVVNADSMQLYRGMDIGTAKLTPEERGGVPHHLLDIWDVTEAASVAEYQRLARAEIDRLLAAGRTPVLVGGSGLYVRGAVDALEFPGTDPAVRARLEAELEERGSGVLHARLTEADPEAARAILPSNGRRIVRALEVIEITGKPFTANLPGPDSVYDTVQIGVDVARPELDERIATRVDRMWEAGLVDEVRTLEAQGLREGRTAARALGYQQVLAALAGECTEDEARAETVRATKRFARRQDSWFRRDPRVHWLSGAVDHRGELPGEALALVERAVTA
>NZ_CP029196.1|WP_150163737.1|5779856_5780249_+|hypothetical-protein
MTPDGPDDAVGTAVEVDADEVEVELRPQRRLRIWQLAPIVGLAAVGSLMFAFPLAFGSGDGGAVLAMLGLLISFCAAGWGMMAARKVGYTWPGLPQRGSGERPNWRYLALYVTTIAALVALAVWRVARLR
>NZ_CP029196.1|WP_150162145.1|5780470_5781340_+|diaminopimelate-epimerase
MTSAQTSPLPFLKGHGTENDFVIVPDAENAVDLPPAVVARLCDRRAGIGGDGLLHVVRSAAHPEARHMAEEAEWFMDYRNADGSVAEMCGNGVRVFARYLEHAGHVTAGRLAVATRGGVKHVHLDKDGSVTVAMGRAVLAEAGVTVTVDGRSWPARNVNMGNPHAVAFVEDLDHAGNLFTEPPYEPAAVYPDGVNIEFVADRGPRHVAMRVHERGAAETRSCGTGACAVAVATARRDGADPAETGTPVTYTVDVLGGTLVITEHPDGQIDMTGPAVIVAEGTVDPAWLG
>NZ_CP029196.1|WP_150162146.1|5781540_5783958_+|HD-domain-containing-protein
MSAEATNPVGAAEAADTDVTVRRRGRARIDLRRLGRAALLGATAGPAPRDRLPDAISHVAEAHRAHHPEADLSVLRRAYVLAESSHRGQFRKSGEPYITHPLAVTLILAELGAETTTLTASLLHDTVEDTEVTLDQVRREFGDEVAYLVDGVTKVEKIDYGAAAEPETFRKMLVATGNDVRVMSIKLADRLHNMRTLGVMRPEKQARIAKVTRDVLIPLAERLGVQALKTELEDLVFAILHPEEYETTRALIAGNPQASDALDAVAEQVATVLREADIGAEVLVRPRHFVSVHRVRLKRGELRGCDFGRLLVLVAEDADCYAVLGELHTCFTPVISEFKDFIAAPKFNLYQSLHTAIAAPDGAVAEVLIRTHRMHTVAEAGVVALGNPHVGQEPAAAPGDLADGDGGAPPASQSHASRPETTSRPGASTRAGSSTRPGASDRSGTTDRRPDADAPLPDAAASPGAAASPGAAASPGADAAPDAAASPAEDGERVDPTRPGWLSRLLDWQQAAPDPDTFWTSLRADLAEDDEITVFRADGGTLGLPAGASCVDAAYAQHGEAAHGCLGARVNGRLTPLSTVLGDGDTVQLLLAQDTVSGPSPEWLDHARTPAARIAIDGWLRAHPESTAPPADTSAPRPQADVPADHRSGAELHADLEGEPRAAVRPAGCCTPVPPDKITGFRVRGGSVTVHRAGCAAVDTMRRLGRTPVAVRWGDTAQGRVTLVAESFGRPGLLADLTEAIAVAGAAVVSATVEPPSEQRVRHTYTLHLPDVGRLAALMRAMRDVPGVYDVSRARHRAPSDPRRA
>NZ_CP029196.1|WP_150162147.1|5784528_5786019_+|M1-family-metallopeptidase
MPLVRTPLPRARWLRSAVLVAASAGLVAAALPAPAPLGIGDPLFPHLGNPGYDVLAYALDLTYPGVNTRPLAAVTRIDAVATDDLERLNLDFTHGTVSAVTVDGLPADYVTSGEDLVVTPAVPIDEGESIEITVTHTSDPSGPGDTGGWVRTGDGLAMANQADAAHRVFPSNDHPADKAYFTFRVTAPSELTVVANGLPIGRVSDGATTTWTYRTGHPMATELAQVSIGRSTVVHRAGPHGLPVRDVVRTADRELMEPWLRRTPGHLEWMERQVGPYPFETYGVLVADATTGFELETQTLSLFERRLFTEPRYPEWYVDSIMVHELAHQWFGDSVSPRTWSDLWLNEGHASWYEALYAEETAGKSLERRMEAAYAASDGWRADGGPPAAPEPPAPGHKISLFRPVVYDGSALVLYALRQEIGTEAFRRLERRWVADHRDGTATTADFIALAGEVAGRDLTGFLRPWLYDKRTPAMPGHPDWRSRPVQAARTAPKPG
>NZ_CP029196.1|WP_150162148.1|5786165_5787659_+|GTPase-HflX
MTSSSSPSQDEQRFAETSRTESLRADALMEEDVAWSHEIDGERDGDQFDRSERAALRRVAGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTVQDAENSLAELAALAETAGALVLDGVIQRRDKPDPATFIGSGKARELRDIVVETGADTVVCDGELSPGQLIALEDVVKVKVVDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGGGGGGMATRGPGETKIETDRRRIREKMAKMRREIAEMKTGRDIKRQERRRNKVPSVAIAGYTNAGKSSLLNRLTGAGVLVENSLFATLDPTVRRAETPTGRVYTLADTVGFVRHLPHHLVEAFRSTMEEVGDSDLILHVVDGSHPAPEEQLAAVREVFRDVGAVNVPEIVVINKADAADPLVLQRLLRMEKHSIVVSARSGQGIEQLLALIDSELPRPEVELEALVPYTQGGLVSRVHAEGEVESEEHTPEGTLLKARVHEELAAMLAPYVPAAH

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Crispr_ID: NZ_CP029196_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_20

5776624-5776840

Orphan

Consensus_repeat	Method
CCGGCCTGCGGCCGCGTCGGCCG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP029196_20

>merge|NZ_CP029196|20|5776624-5776840|CRISPRCasFinder
CCGGCCTGCGGCCGCGTCGGCCGAGGGCCTGCGCCCTGAGCCCGCGGCACGGCCCGCGTCACTGGCCTGTGGCCACCGCCGGCCTGCGGCCGCCTCGGCCGTCGGCCCGCTGCGTGAGTTCGCGGCTCGGGCTCGCGCCACCGGGGCCACCAGCGGCCCGCGGCCCCGGTGGCTTGAGGCCACGCCACCAGCCCGCGGCCGACCGGCGCGTGGCCCG

>NZ_CP029196|20|16|5776624-5776840|CRISPRCasFinder
CCGGCCTGCGGCCGCGTCGGCCG	AGGGCCTGCGCCCTGAGCCCGCGGCACGGCCCGCGTCACTGGCCTGTGGCCACCG
CCGGCCTGCGGCCGCCTCGGCCG	TCGGCCCGCTGCGTGAGTTCGCGGCTCGGGCTCGCGCCACCGGGGCCACCA
GCGGCCCGCGGCCCCGGTGGCTT	GAGGCCACGCCACCAGCCC
GCGGCCGACCGGCGCGTGGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150162146.1\|5781540_5783958_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|223394
NZ_CP029196.1\|WP_150162142.1\|5776930_5777668_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153388
NZ_CP029196.1\|WP_150162137.1\|5768975_5770292_+\|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl\|CDD\|234607
NZ_CP029196.1\|WP_106433750.1\|5778166_5778316_-\|gliding-motility-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162141.1\|5774967_5776497_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237674
NZ_CP029196.1\|WP_150162144.1\|5778320_5778653_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240291
NZ_CP029196.1\|WP_150162138.1\|5770372_5770789_-\|Ohr-family-peroxiredoxin	unknown	unknown	gnl\|CDD\|274649
NZ_CP029196.1\|WP_150163736.1\|5772691_5773840_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP029196.1\|WP_150162145.1\|5780470_5781340_+\|diaminopimelate-epimerase	unknown	unknown	gnl\|CDD\|234768
NZ_CP029196.1\|WP_150162139.1\|5770940_5772029_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP029196.1\|WP_150163735.1\|5772056_5772695_-\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP029196.1\|WP_150162135.1\|5765335_5766802_+\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
NZ_CP029196.1\|WP_150162140.1\|5774090_5774756_-\|DedA-family-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP029196.1\|WP_150162148.1\|5786165_5787659_+\|GTPase-HflX	unknown	unknown	gnl\|CDD\|225171
NZ_CP029196.1\|WP_150162136.1\|5766798_5768979_+\|acetyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|223972
NZ_CP029196.1\|WP_150162134.1\|5764311_5765331_+\|porphobilinogen-synthase	unknown	unknown	gnl\|CDD\|236450
NZ_CP029196.1\|WP_150162143.1\|5777781_5778114_-\|antitoxin	unknown	unknown	gnl\|CDD\|379416
NZ_CP029196.1\|WP_015036648.1\|5778689_5779628_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	unknown	unknown	gnl\|CDD\|234626
NZ_CP029196.1\|WP_150163737.1\|5779856_5780249_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162147.1\|5784528_5786019_+\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341066

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150162146.1\|5781540_5783958_+\|HD-domain-containing-protein	gnl\|CDD\|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	5.84093e-119
NZ_CP029196.1\|WP_150162142.1\|5776930_5777668_+\|hypothetical-protein	gnl\|CDD\|153388	cd07951, ED_3B_N_AMMECR1, The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain. This subfamily is composed of uncharacterized proteins containing an N-terminal domain with similarity to the catalytic B subunit of class III extradiol dioxygenases and a C-terminal AMMECR1-like domain. This model represents the N-terminal domain. Class III extradiol dioxygenases use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon, however, proteins in this subfamily do not contain a potential metal binding site and may not exhibit class III extradiol dioxygenase-like activity. The AMMECR1 protein was proposed to be a regulatory factor that is potentially involved in the development of AMME contiguous gene deletion syndrome.	7.44783e-56
NZ_CP029196.1\|WP_150162137.1\|5768975_5770292_+\|glutamate-1-semialdehyde-2,1-aminomutase	gnl\|CDD\|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NZ_CP029196.1\|WP_015036648.1\|5778689_5779628_+\|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	5.19213e-147
NZ_CP029196.1\|WP_150162141.1\|5774967_5776497_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237674	PRK14326, PRK14326, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP029196.1\|WP_150162144.1\|5778320_5778653_-\|hypothetical-protein	gnl\|CDD\|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	8.54958e-06
NZ_CP029196.1\|WP_150162138.1\|5770372_5770789_-\|Ohr-family-peroxiredoxin	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	1.36452e-62
NZ_CP029196.1\|WP_150163736.1\|5772691_5773840_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.17966e-36
NZ_CP029196.1\|WP_150162145.1\|5780470_5781340_+\|diaminopimelate-epimerase	gnl\|CDD\|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	1.06554e-103
NZ_CP029196.1\|WP_150162139.1\|5770940_5772029_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	1.15354e-95
NZ_CP029196.1\|WP_150163735.1\|5772056_5772695_-\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.50439e-37
NZ_CP029196.1\|WP_150162135.1\|5765335_5766802_+\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	1.91458e-133
NZ_CP029196.1\|WP_150162140.1\|5774090_5774756_-\|DedA-family-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	7.96295e-42
NZ_CP029196.1\|WP_150162148.1\|5786165_5787659_+\|GTPase-HflX	gnl\|CDD\|225171	COG2262, HflX, GTPases [General function prediction only].	3.1255e-170
NZ_CP029196.1\|WP_150162136.1\|5766798_5768979_+\|acetyl-CoA-synthetase	gnl\|CDD\|223972	COG1042, COG1042, Acyl-CoA synthetase (NDP forming) [Energy production and conversion].	8.05773e-128
NZ_CP029196.1\|WP_150162134.1\|5764311_5765331_+\|porphobilinogen-synthase	gnl\|CDD\|236450	PRK09283, PRK09283, porphobilinogen synthase.	0
NZ_CP029196.1\|WP_150162143.1\|5777781_5778114_-\|antitoxin	gnl\|CDD\|379416	pfam14013, MT0933_antitox, MT0933-like antitoxin protein. This family of proteins contains the MT0933 protein, which has been identified as an antitoxin to /protein MT0934. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	4.62588e-16
NZ_CP029196.1\|WP_150162147.1\|5784528_5786019_+\|M1-family-metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.13836e-141

>NZ_CP029196.1|WP_150162141.1|5774967_5776497_+|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MTSSSDRSTAVSVDGTKTYEIRTYGCQMNVHDSERLSGLLEEAGYVKAPKGSDGDADVVVFNTCAVRENADNKLYGNLGRLAPMKTTRPGMQIAVGGCLAQKDRETIVSKAPWVDVVFGTHNIGKLPVLLERARVQEEAQIEIAESLEAFPSTLPTRRESAYAAWVSISVGCNNTCTFCIVPALRGKEEDRRPGDILAEIEALVAEGVSEITLLGQNVNAYGSDLGDREAFSKLLRACGQIEGLERVRFTSPHPRDFTDDVIAAMAETPNVMPQLHMPLQSGSDSILRAMRRSYRQERFLGIIEKVRAAIPHAAISTDIIVGFPGETEEDFEQTMHTVREARFANAFTFQYSKRPGTPAADMEGQIPKEVVQERYMRLVALQEEISWEENKKQVGRTLEVMVAEGEGRKDGATDRLSGRAPDNRLVHFTKPDEDVRPGDVVTVEITYAAPHHLLAEGPVASVRRTRAGDAWQKRTTPAPTKPPGVLLGLPTIGAPAPLPAAEVPACGSH
>NZ_CP029196.1|WP_150162140.1|5774090_5774756_-|DedA-family-protein
MNLTTMALAQQPADGIAGWAAGLVDTMGGPGAGLAIALENLFPPLPSEIILPLTGFAAGQGVLSLTSALFWTTLGSVAGAVALYWIGALFGRERMHAIWGRLPLVKASDLVRTEEWFARHGGKAVFLGRMVPVFRSLISVPAGVERMPMPRFIMLTTLGSLVWNSVLVVAGYALGDRWDVVESYVGVLSKAVVALVGVACAAYVAVRLRGRGRGAQHRRTS
>NZ_CP029196.1|WP_150163736.1|5772691_5773840_-|sensor-histidine-kinase
MPRLRRGLPRLRRGLGTVFGCVTAAAGALHFLVGGLALGPFLLWPRTRAGALDLLTGGVRRLAALERARRSVFFGDVFPEHYRAADRKVLRYLAVRSYAGLLCALVLGLLVFGAVLAGILGYGVLRGTIGWDELLTQVLLGGVLLFLDVQGLYALAALDARTARECFGPSERELLRRRIEELAASRAAVVEAVDAERRRIERDLHDGVQQRLVALGMLIGRARRGRDPERAGALLLQAHEESRGVLAELREVAWRAYPSALDSLGLEEALGGVAERCALPLRLRFEVAGPLPRAVETAAYFVVSECVTNAAKHSAASAVSVSVAREGALLTVRVEDDGSGGANENGGGLTGLRSRVAALDGVLRVHSPLGGPTTVTAELPCA
>NZ_CP029196.1|WP_150163735.1|5772056_5772695_-|response-regulator
MILAEDSTLLREGLVRLLAEEGHEVLAALGDAVTLVREVGEQRPDLVVVDIRMPPTHTDEGLRAAVEIRRRWPGVGVLVLSQYVERPYAAELLAAGAERVGYLLKDRVAQVEEFLDALERIHAGGAAIDPEVVRQLVVRTTHGDPLARLTPRERTVLEALAQGHTNTAIAAKLHLSLSSVEKNLNAVFDKLELTRATGYSRRILAVLRYLEA
>NZ_CP029196.1|WP_150162139.1|5770940_5772029_+|CoA-transferase
MAGPLTGVRVLEFAGSAPTAFVGTVLSGLGADVVRVDRAPGAAPGPGARPAENPLSRGRRSVALDLKTPAGVEEALALAEHADILVEGFRPGVAERLGIGPDAARARNPRLVYGRVSGWGQQGEWAGRAAHDLAVLALTGALDTDPATGDPVLPPTAYLSSFAGGASVHVQALLAALHERERSGLGQVVDTALADGAALISTLIHQWREVPGNHTVTDAPHYSLYRAADGRHLAVAAIEPKLYQNLLEQLGLADTDDLPDRTDPADWPALRALIADRFASRDRDHWAKVFDAVDAGVAPVLTAAEAAGHHQLAARGAFVTVGDSTVPQPAPPSRFDRTPAVPPSRAPLPGEHTDEVLAEWRR
>NZ_CP029196.1|WP_150162138.1|5770372_5770789_-|Ohr-family-peroxiredoxin
MAVVYTAEVISTGDGRNGAVRSSDGLLDLPLSSPKAVGGSGTATNPEQLFAAGYAACFHSALRVSAREAKVALADDTVVAEVALHKEESGFRLSVVLTVELPGIDESEARRLAEAAHGRCPYSKAVRGNVEVRVDIAP
>NZ_CP029196.1|WP_150162137.1|5768975_5770292_+|glutamate-1-semialdehyde-2,1-aminomutase
MSGVGTGGGGTASKALFERAREVTPGGVNSPVRAFGAVGGTPPFMASAQGPYLTDADGNEYVDLICSWGPMILGHRHPAVVEAVTGALALGTSFGAPSTGEVELAEEIVDRVDPVEQVRLVSSGTEATMSAIRLARGFTGRGKIVKFAGCYHGHVDALLASAGSGLATFALPDTPGVTGAQASDTIVLPYNDLAAVEKVFAEIGDEIAAVITEAAPGNMGAVPPLPGFNAGLKDVTSRHGALFISDEVMTGFRASRSGWYGRDGVAPDLLTFGKVMGGGFPAAAFGGRADVMAHLAPAGPVYQAGTLSGNPVATAAGLATLRHSTPEVYERLDEVSATLGREVSAALTKEGVAHRVQYSGTMFSVFFTEDEVTDFDGVRATESYRYPPFFHELLRRGVYLPPSPFEAWFVSAAHDDRAVGRVVEALPAAAAAAASAKP
>NZ_CP029196.1|WP_150162136.1|5766798_5768979_+|acetyl-CoA-synthetase
MSDISALWEAESIAVIGASERPGALGRKPLDYLLRYGYKGRILPVNPRSPEILGVPAYPSVKDAPGPVDLALIMVSAERVLGAVDDCVAAGVKLAVIASSGFAETGEEGARLQAEVVAKARAGGLRIIGPNCIGAVGYENRVLATFSPLFGAESVPFEPGTLAFVSQSGALGFGAASLALERGLRPGWVVSTGNDADVTALEVLRELAAVPDVTGLLGYLEDTPDIDTLRALAGSGKPVALLKSGRTEAGGRAAASHTGALATDDRVLDAALRGLGVVRVDDIDELLDVARVFESERRPAGNRVAVVTTSGGSGILAADAVEAHGLQLSTLEPRSKEALAEIVPAFGAIDNPVDITATVLSDPSLFDRSLDVLIADDTVDIIVAAFCVMAGPDVEKAVNALSRAAAKGGKPILVARTGADFLAPDAPRDLREAGLPEYPTPARALRAAAALWEVSRPRTLPDAPRPGTVPGPGAQATEPELKRLLAEAGIPVPKGRIAENAEDAVRAVTEVGGTAVFKAVVPGLLHKTEAGGVEIGVTTAGAPAAYARLAALGGQVLVEELVGEGVELIVGVHTTDLGPVLTAGLGGIFTEVLDDVGHRLLPLAPGEGAELLAALRGAKILAGARGRAAVDVDAAAELLHKVAELAQGWPAGYALDLNPVRVLPKGAVVLDAALGIETATGDETAPGAETTPGEETVPGGDAASGAETASGAETASGLAAAEGAAR
>NZ_CP029196.1|WP_150162135.1|5765335_5766802_+|glutamyl-tRNA-reductase
MSPSSTMLVLGISHASAPLDLLERLAGTDRPAEDLVADVTSVDGIDAAVVVSTCNRLEIYAETRDDGAGPGAAGELTGLGELFAQHTGVDHEEIAPHLYSHHADGAVRHLFAVASGLESVVVGEDQILGQVKLGLERSQRLDRTGRVLAKAVQTALRVGKRARNETGLNEAGRSLATAGLGFFERRVGSLHGKTALVIGAGAFAGVVVAALRRSGLDRVHVANRTPEKAQRLAETTGGVGYDLADVPRLLTEVDVVVGATAATGHLVTAGQVEQALAARDGRELFLLDLSLPHNIAPAAAALPGVTFVDLRRIAEEGQEDEISAASVQAAHELIDAEVEQFRTGLRLAGATPVLTALRTAATEAAQVELDRLARRLEGVDGTVRREIDRSVRRIVDKALHQPTVLVRELAADPDGARHIAAFTRLFAAAEAEGGAGSTTPNGPNPPSAQNDPHAKSDPHANSDPHAKNDPHAKNDPNAQNETKIEAIA
>NZ_CP029196.1|WP_150162134.1|5764311_5765331_+|porphobilinogen-synthase
MTYDAYGRNTAATDPAAPYYRPRRLRRTPALRRFAAETRVGPANLVQPLFLREGLTEAREIPSMPGVLQHTRDTLRKAATEAVANGVGGLILFGIPEHKDPTGTGAIDPDGILQVALRDVVAEVGDSTVIIGDINLDEYTDHGHTGVLDAHGDVDNDASIELYAQAAVVQADAGAQIVAPSGMMDGQVRRIREALDQAGHQSVAILGYSAKYASHFYGPFRDAVESTLRGDRKGYQQFPGNIRESLLEVSLDVAEGADLVMVKPALAYLDIVRLIADHVQVPVAAYQVSGEYSMVEAAAAKGWIDRDQVVRESLASIHRAGATQIITYWASEFAQTLDR
>NZ_CP029196.1|WP_150162142.1|5776930_5777668_+|hypothetical-protein
MLVAAAVCPSPPLLVPEVATGAAPELDAARAACLDAVGLLAAARPDRLYVVGPAPEGAHGVYPAGSAGSFEGFGVDLSVRLGDDASEDERPDGRPVEDRPLPASLAVAAWLLGRAAWADAPIEGLGVDGAATPDVCAGLGRGLAEAADRVALLVMGDGSACRTVKAPGYLDERAEGFDAAAARALGTADAAALLALDPELAFELKVAGRAPWQVLAGAAEGAGLDGRLLFEDAPYGVGYFVAAWS
>NZ_CP029196.1|WP_150162143.1|5777781_5778114_-|antitoxin
MGLLDSLKAKLAPAKDKVADLAQQHGDKIDHGIDKAARLVDEKTKGKYSDKIHSGTDKAKDALDRIGHKDDGTPGTGTPGGGTPGTGTPGTGTPGTGTPGSGGTTPPPTV
>NZ_CP029196.1|WP_106433750.1|5778166_5778316_-|gliding-motility-protein
MEDEEADGVDAVDTDEAVAGAVATETVEIPKQQSADAAADNEAGEGART
>NZ_CP029196.1|WP_150162144.1|5778320_5778653_-|hypothetical-protein
MSYVTGLIRLRCLLRGSGRRSLRNPSHPSTLWSEYGRFCSVSPEEEGCGRGHGLCGGDRGRRSGRRSGRRRRRGRGGRPGGRDPVRGGGRGGRRRRGGGAGREHGRGPER
>NZ_CP029196.1|WP_015036648.1|5778689_5779628_+|tRNA-(adenosine(37)-N6)-dimethylallyltransferase-MiaA
MRSAAPAPRVIAVVGPTAAGKSDLGVFLAQQLGGEVVNADSMQLYRGMDIGTAKLTPEERGGVPHHLLDIWDVTEAASVAEYQRLARAEIDRLLAAGRTPVLVGGSGLYVRGAVDALEFPGTDPAVRARLEAELEERGSGVLHARLTEADPEAARAILPSNGRRIVRALEVIEITGKPFTANLPGPDSVYDTVQIGVDVARPELDERIATRVDRMWEAGLVDEVRTLEAQGLREGRTAARALGYQQVLAALAGECTEDEARAETVRATKRFARRQDSWFRRDPRVHWLSGAVDHRGELPGEALALVERAVTA
>NZ_CP029196.1|WP_150163737.1|5779856_5780249_+|hypothetical-protein
MTPDGPDDAVGTAVEVDADEVEVELRPQRRLRIWQLAPIVGLAAVGSLMFAFPLAFGSGDGGAVLAMLGLLISFCAAGWGMMAARKVGYTWPGLPQRGSGERPNWRYLALYVTTIAALVALAVWRVARLR
>NZ_CP029196.1|WP_150162145.1|5780470_5781340_+|diaminopimelate-epimerase
MTSAQTSPLPFLKGHGTENDFVIVPDAENAVDLPPAVVARLCDRRAGIGGDGLLHVVRSAAHPEARHMAEEAEWFMDYRNADGSVAEMCGNGVRVFARYLEHAGHVTAGRLAVATRGGVKHVHLDKDGSVTVAMGRAVLAEAGVTVTVDGRSWPARNVNMGNPHAVAFVEDLDHAGNLFTEPPYEPAAVYPDGVNIEFVADRGPRHVAMRVHERGAAETRSCGTGACAVAVATARRDGADPAETGTPVTYTVDVLGGTLVITEHPDGQIDMTGPAVIVAEGTVDPAWLG
>NZ_CP029196.1|WP_150162146.1|5781540_5783958_+|HD-domain-containing-protein
MSAEATNPVGAAEAADTDVTVRRRGRARIDLRRLGRAALLGATAGPAPRDRLPDAISHVAEAHRAHHPEADLSVLRRAYVLAESSHRGQFRKSGEPYITHPLAVTLILAELGAETTTLTASLLHDTVEDTEVTLDQVRREFGDEVAYLVDGVTKVEKIDYGAAAEPETFRKMLVATGNDVRVMSIKLADRLHNMRTLGVMRPEKQARIAKVTRDVLIPLAERLGVQALKTELEDLVFAILHPEEYETTRALIAGNPQASDALDAVAEQVATVLREADIGAEVLVRPRHFVSVHRVRLKRGELRGCDFGRLLVLVAEDADCYAVLGELHTCFTPVISEFKDFIAAPKFNLYQSLHTAIAAPDGAVAEVLIRTHRMHTVAEAGVVALGNPHVGQEPAAAPGDLADGDGGAPPASQSHASRPETTSRPGASTRAGSSTRPGASDRSGTTDRRPDADAPLPDAAASPGAAASPGAAASPGADAAPDAAASPAEDGERVDPTRPGWLSRLLDWQQAAPDPDTFWTSLRADLAEDDEITVFRADGGTLGLPAGASCVDAAYAQHGEAAHGCLGARVNGRLTPLSTVLGDGDTVQLLLAQDTVSGPSPEWLDHARTPAARIAIDGWLRAHPESTAPPADTSAPRPQADVPADHRSGAELHADLEGEPRAAVRPAGCCTPVPPDKITGFRVRGGSVTVHRAGCAAVDTMRRLGRTPVAVRWGDTAQGRVTLVAESFGRPGLLADLTEAIAVAGAAVVSATVEPPSEQRVRHTYTLHLPDVGRLAALMRAMRDVPGVYDVSRARHRAPSDPRRA
>NZ_CP029196.1|WP_150162147.1|5784528_5786019_+|M1-family-metallopeptidase
MPLVRTPLPRARWLRSAVLVAASAGLVAAALPAPAPLGIGDPLFPHLGNPGYDVLAYALDLTYPGVNTRPLAAVTRIDAVATDDLERLNLDFTHGTVSAVTVDGLPADYVTSGEDLVVTPAVPIDEGESIEITVTHTSDPSGPGDTGGWVRTGDGLAMANQADAAHRVFPSNDHPADKAYFTFRVTAPSELTVVANGLPIGRVSDGATTTWTYRTGHPMATELAQVSIGRSTVVHRAGPHGLPVRDVVRTADRELMEPWLRRTPGHLEWMERQVGPYPFETYGVLVADATTGFELETQTLSLFERRLFTEPRYPEWYVDSIMVHELAHQWFGDSVSPRTWSDLWLNEGHASWYEALYAEETAGKSLERRMEAAYAASDGWRADGGPPAAPEPPAPGHKISLFRPVVYDGSALVLYALRQEIGTEAFRRLERRWVADHRDGTATTADFIALAGEVAGRDLTGFLRPWLYDKRTPAMPGHPDWRSRPVQAARTAPKPG
>NZ_CP029196.1|WP_150162148.1|5786165_5787659_+|GTPase-HflX
MTSSSSPSQDEQRFAETSRTESLRADALMEEDVAWSHEIDGERDGDQFDRSERAALRRVAGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTVQDAENSLAELAALAETAGALVLDGVIQRRDKPDPATFIGSGKARELRDIVVETGADTVVCDGELSPGQLIALEDVVKVKVVDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGGGGGGMATRGPGETKIETDRRRIREKMAKMRREIAEMKTGRDIKRQERRRNKVPSVAIAGYTNAGKSSLLNRLTGAGVLVENSLFATLDPTVRRAETPTGRVYTLADTVGFVRHLPHHLVEAFRSTMEEVGDSDLILHVVDGSHPAPEEQLAAVREVFRDVGAVNVPEIVVINKADAADPLVLQRLLRMEKHSIVVSARSGQGIEQLLALIDSELPRPEVELEALVPYTQGGLVSRVHAEGEVESEEHTPEGTLLKARVHEELAAMLAPYVPAAH

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Crispr_ID: NZ_CP029196_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_21

6080660-6080744

Orphan

Consensus_repeat	Method
GGCGACCTCGACGCAGTTGTCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_21

>merge|NZ_CP029196|21|6080660-6080744|CRISPRCasFinder
GGCGACCTCGACGCAGTTGTCGCCGCTACCGCTGCTGTAGCTGGACTTGTGCCAGGAGAGGGCGACTTCGACGCAGTTGTCGCCG

>NZ_CP029196|21|17|6080660-6080744|CRISPRCasFinder
GGCGACCTCGACGCAGTTGTCGCCG	CTACCGCTGCTGTAGCTGGACTTGTGCCAGGAGAG
GGCGACTTCGACGCAGTTGTCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150162309.1\|6081772_6082210_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP029196.1\|WP_150162311.1\|6084587_6084992_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319924
NZ_CP029196.1\|WP_150162308.1\|6080790_6081624_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_CP029196.1\|WP_150162304.1\|6078362_6079292_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP029196.1\|WP_150162312.1\|6085211_6085838_+\|nucleoside/nucleotide-kinase-family-protein	unknown	unknown	gnl\|CDD\|236442
NZ_CP029196.1\|WP_150162299.1\|6072103_6072910_+\|pyrimidine-reductase-family-protein	unknown	unknown	gnl\|CDD\|184482
NZ_CP029196.1\|WP_015037051.1\|6075148_6075556_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|376583
NZ_CP029196.1\|WP_150162316.1\|6088160_6089120_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237463
NZ_CP029196.1\|WP_150162305.1\|6079301_6079667_+\|DUF1801-domain-containing-protein	unknown	unknown	gnl\|CDD\|378058
NZ_CP029196.1\|WP_150162302.1\|6076288_6077281_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP029196.1\|WP_150162300.1\|6073740_6075132_+\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
NZ_CP029196.1\|WP_150162306.1\|6079684_6080470_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187605
NZ_CP029196.1\|WP_150162313.1\|6085851_6086598_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180452
NZ_CP029196.1\|WP_150162303.1\|6077277_6078273_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176231
NZ_CP029196.1\|WP_041663027.1\|6073016_6073499_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162314.1\|6086694_6087219_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|315378
NZ_CP029196.1\|WP_150162315.1\|6087229_6088111_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
NZ_CP029196.1\|WP_150162317.1\|6089240_6090407_+\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|238525
NZ_CP029196.1\|WP_150162301.1\|6075515_6076292_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235816
NZ_CP029196.1\|WP_150162310.1\|6082223_6084230_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|237358

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150162309.1\|6081772_6082210_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	9.65037e-16
NZ_CP029196.1\|WP_150162311.1\|6084587_6084992_-\|VOC-family-protein	gnl\|CDD\|319924	cd07263, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.44903e-41
NZ_CP029196.1\|WP_150162308.1\|6080790_6081624_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	6.27865e-08
NZ_CP029196.1\|WP_150162304.1\|6078362_6079292_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	4.41319e-28
NZ_CP029196.1\|WP_150162312.1\|6085211_6085838_+\|nucleoside/nucleotide-kinase-family-protein	gnl\|CDD\|236442	PRK09270, PRK09270, nucleoside triphosphate hydrolase domain-containing protein; Reviewed.	1.98519e-86
NZ_CP029196.1\|WP_150162299.1\|6072103_6072910_+\|pyrimidine-reductase-family-protein	gnl\|CDD\|184482	PRK14059, PRK14059, pyrimidine reductase family protein.	4.28886e-89
NZ_CP029196.1\|WP_015037051.1\|6075148_6075556_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	1.45693e-76
NZ_CP029196.1\|WP_150162316.1\|6088160_6089120_+\|hypothetical-protein	gnl\|CDD\|237463	PRK13668, PRK13668, hypothetical protein; Provisional.	6.65123e-05
NZ_CP029196.1\|WP_150162305.1\|6079301_6079667_+\|DUF1801-domain-containing-protein	gnl\|CDD\|378058	pfam08818, DUF1801, Domain of unknown function (DU1801). This large family of bacterial proteins is uncharacterized. They contain a presumed domain about 110 amino acids in length.	1.56042e-23
NZ_CP029196.1\|WP_150162300.1\|6073740_6075132_+\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
NZ_CP029196.1\|WP_150162306.1\|6079684_6080470_-\|SDR-family-oxidoreductase	gnl\|CDD\|187605	cd05347, Ga5DH-like_SDR_c, gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs. Ga5DH catalyzes the NADP-dependent conversion of carbon source D-gluconate and 5-keto-D-gluconate. This SDR subgroup has a classical Gly-rich NAD(P)-binding motif and a conserved active site tetrad pattern. However, it has been proposed that Arg104 (Streptococcus suis Ga5DH numbering), as well as an active site Ca2+, play a critical role in catalysis. In addition to Ga5DHs this subgroup contains Erwinia chrysanthemi KduD which is involved in pectin degradation, and is a putative 2,5-diketo-3-deoxygluconate dehydrogenase. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107,15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.42262e-75
NZ_CP029196.1\|WP_150162313.1\|6085851_6086598_-\|hypothetical-protein	gnl\|CDD\|180452	PRK06186, PRK06186, hypothetical protein; Validated.	1.33413e-110
NZ_CP029196.1\|WP_150162303.1\|6077277_6078273_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176231	cd08270, MDR4, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	2.03007e-83
NZ_CP029196.1\|WP_150162302.1\|6076288_6077281_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	9.14282e-08
NZ_CP029196.1\|WP_150162314.1\|6086694_6087219_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|315378	pfam12688, TPR_5, Tetratrico peptide repeat. BH0479 of Bacillus halodurans is a hypothetical protein which contains a tetratrico peptide repeat (TPR) structural motif. The TPR motif is often involved in mediating protein-protein interactions. This protein is likely to function as a dimer. The first 48 amino acids are not present in the clone construct. This Pfam entry includes tetratricopeptide-like repeats not detected by the pfam00515, pfam07719, pfam07720 and pfam07221 models.	1.06901e-34
NZ_CP029196.1\|WP_150162315.1\|6087229_6088111_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.28829e-25
NZ_CP029196.1\|WP_150162317.1\|6089240_6090407_+\|M24-family-metallopeptidase	gnl\|CDD\|238525	cd01092, APP-like, Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.	8.27132e-104
NZ_CP029196.1\|WP_150162301.1\|6075515_6076292_-\|SDR-family-oxidoreductase	gnl\|CDD\|235816	PRK06500, PRK06500, SDR family oxidoreductase.	3.39758e-85
NZ_CP029196.1\|WP_150162310.1\|6082223_6084230_-\|elongation-factor-G	gnl\|CDD\|237358	PRK13351, PRK13351, elongation factor G-like protein.	0

>NZ_CP029196.1|WP_150162306.1|6079684_6080470_-|SDR-family-oxidoreductase
MSTTPGGYLSDLFSLDGRTALVTGGSSGIGRAVAGALARAGARVVVLARKEAELTATVEELTADGCRAAWVSADLSTREGIKAGAEAAAAVFGEPDILVNSAGINLRPPFGELGEEVWDTTMTVNLEAPFLLGRRFGPGMAERGFGRIIHITSQQAHRAFVQSGAYGVSKGALESLARSQAEAWSPYGVTANTLVPGFVMTALNQRLSSDPEKVAALAARTMVGRNGLAEDFAGAAVFLASTSSAYVTGQSLFVDGGFSVH
>NZ_CP029196.1|WP_150162305.1|6079301_6079667_+|DUF1801-domain-containing-protein
MVQSSAEDVDGYLAEVPEDRREALTRLRRLCRAELTGFDEVMAYGMPAYERNGTAEIAFASQKQYISFYLMRSDVREAFEERLAAQDMGKGCLRFRKPERVDFSLVRDLLKATAAAPGTVC
>NZ_CP029196.1|WP_150162304.1|6078362_6079292_+|LysR-family-transcriptional-regulator
MDLDTAQLRAFVHAAREAHFGRAAADLSLTQQALSKRIARLESLLGTRLFERLGHGVALTEAGRRLLDPARRVLAATDDAVAAVASEERPLRVDVWGHLYAPMRTLRQVAGPARELELGHGRDLPAVSAALLHGDVDAAFGRVHPPLPAGLTHRLVRLEPVDAVLSAGHPLAAEPALRPEQLRDSVLWAPGALDRLDFLRRFADRFGVRERAGSVNLGLAPFLTEVAADPRRFSLLPADVPLPDVPGLCSVPLVDPTPLYAWSLLWRTGNPHPGLSGLAAACAGEAGRSRWLEYDPTRDWLPDDPEPPL
>NZ_CP029196.1|WP_150162303.1|6077277_6078273_-|zinc-binding-dehydrogenase
MRQLIPTGDALRPVEFTEAPQPVPGPHEALVKVEAFAPNRGETFLLERPALGLLPGKDIAGLVVQAAADGSGPGIGTRVVGHPPHGGWAEYAAVPTHSLAVLPDGIDSVRAAALPLAGITALRLLRTAGSLAGARVLLTGASGGVGHYVTELAVAAGAELTVVTATPERGARLAELGAAEVVHEVADARGPYDVVLESTGGPHLPVAVSKVRPGGLVVWFGQASRTPATLDFFELLGGPERVTIRHFHYAGAPYGHDLAALVRLVERGRLHPEIGRTADWSETADVLVGLRERRVRGKAVLTTGAARTAEHPATTGAARTAGHIATTGATR
>NZ_CP029196.1|WP_150162302.1|6076288_6077281_-|alpha/beta-fold-hydrolase
MSAGEFAAAQWSRALGAGLDPQEYRWVTEDLASVADWGPAFRRTARGHVRRAEQAGSARSTGEFLLTAARWFHVATLAPYEEADAAAAEADDALGRGLALLEPGARRISGPEFTGWLRGPADAPGTVIVVPGLDSAKEEFLDLASALLARGLAVFAMDGPGQGVLRATTTKRADYHHVVGRVVDALGVPRVGVVGLSLGGYYAAETAALEPRVAAVATVSGPFRLDWAELPPPVRDILIRRTGGEAAARAFTGRVDLSGLAPRIEAPLLTVDGARDVIPGVTNGEPLARLAPRGAYVCVPEGDHLLGNARAAWLPLLADWITHTLTGAHA
>NZ_CP029196.1|WP_150162301.1|6075515_6076292_-|SDR-family-oxidoreductase
MNRFTGRTVLITGGTSGMGLATAHRLLSEGAHVVVTGRTRDRVDAAVAELGPRASGAVADVADLGAVDALMDLVRERHGRLDSVFANAGAGTFLPFEEITEAAFDRTVDVNLKGVFFTVQKALPLLVDGGSVVINASWTLHRGNSVLTLYSATKAAVHNLARTLAAGLAPRGIRVNSVSPGYIDTPMYPAASLSEAEAAAVTGGIVAGRFGRPAEVAAAVAFLASADASYVNGQDLVVDGGLVGSVSPPPAPAGARSS
>NZ_CP029196.1|WP_015037051.1|6075148_6075556_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MAYDVEKPDEQWRAELTPAEYQVLRQAGTEPAFRGEYTDTTTKGVYSCRACGAELFTSTEKFESHCGWPSFYDPKDSSAVELIADTSHGMVRTEVRCSRCGSHLGHVFEGEGYPTPTDQRYCINSISLRLEPEAG
>NZ_CP029196.1|WP_150162300.1|6073740_6075132_+|UDP-N-acetylmuramate--L-alanine-ligase
MAPAIPAAMERPHFIGIGGAGMSGIAKILAQRGAKVAGSDAKESATAESLRALGATVHIGHAAEHLADDASAVVVSSAIRADNPELARAAELGIPVVHRSDALASLMDGLRAIAVAGTHGKTTTTSMLAVALTELGLDPSYAIGGDLAGPGTNALHGDGEVFVAEADESDRSFQKYDPEVAIVLNVELDHHANYASMDEIYESFEAFTAKIRPGGTLVVGEHAGARELARRVADREGLGIVTVGESEDSDARILKIVPNGMKSEVTVALDGVEHTFTVSVPGRHYAHNAAAALAAGARVGIDPAELAQALTAYTGVGRRLQLKGEAKGVQVIDSYAHHPTEMTADLEAMRGAAGASRLLVVFQPHLFSRTQELGKEMGDALALADRSVVLDIYPAREDPIPGITSELIIAAARQAGADVTAVHDKAAVPGVMAGMAGPGDLVLTMGAGDVTDLGPLILDHLSK
>NZ_CP029196.1|WP_041663027.1|6073016_6073499_+|hypothetical-protein
MFTSVLMIEKPLTSVDVEFVTTLHGDEGMSFIVLMQPRGDQADVLLRAIDDVAMGELKEAAREGDEPEGKAARVPAEEALEYSLRALRNAGCEAVGQVVEDHPLDKMKAVVDESAADEVIVLTAPHYVEEFFHRDWASRARHKVGVPVLKLFAHSEEAGE
>NZ_CP029196.1|WP_150162299.1|6072103_6072910_+|pyrimidine-reductase-family-protein
MRRLLPVTDMTEPETAGREWSLDELADAYAYPELPPAGAAGSGGEAGDGAWLRANMVSSLDGAGQHDGRSQPLSSEEDMRIFGTLRALADVVVVGAETVRLEGYRPARAREAFAARREAAGQGPAPAIAVVSASLNLDFSLPLFTEPLVPTLVLTGAAAPAERVAAARAAGAEVLVAGDGAGVEPARARAVLAERGLRRQLTEGGPRLLGQFVAADALDELCLTVSPTMTSGAAQRIAGGPAVAVPTRFQVASVLEQDGFLFTRYRRI
>NZ_CP029196.1|WP_150162308.1|6080790_6081624_-|helix-turn-helix-domain-containing-protein
MTDEVPKGSEPETSESLKAFGEVVKVFRKRAGLTQEQFAPQVGYSVPMIASIEQGRRLPSKEFVDRAEERLDAFGVIRAAAKHLTRRAGLAKWFEGWAELEPLAVTLYTYENRLVPGLFQTPAYARTLFEKQIPAMGDDKIESNLIRRMERASILTERPETIFSFIIEEAALRRQMGGPEVMHEQIDHILALGDRRNIDIQIMPESRGHHAGLDGPLCLLETEENAWYAYSEGQRTAQLISDPKEVSILQQRYARMRAQALSVEASVSLLREIRGAL
>NZ_CP029196.1|WP_150162309.1|6081772_6082210_+|ATP-binding-protein
MTSPVTREAPVTVRVFTQRFSSTPRGARLARRLALHQLDRWRIPYGSEASDAAALLVAELAANAVTHGRVPGRDFELTLAYTPGLRLRIDVSDTRGERRPASTTPGPLDEGGRGLLLVGALASRWAVLDRVPVGKTVRAELDLGP
>NZ_CP029196.1|WP_150162310.1|6082223_6084230_-|elongation-factor-G
MRTTQLTGLVRNLGILAHVDAGKTTVTERFLYLTGATHKRGEVHDGTTVTDFDPQERDRGITIFAAAVSCDWAGHRINLIDTPGHVDFSDEVERSLRVLDGAVAVFDAVAGVEPQSETVWRQADRHGVPRLAFVNKLDRAGAELDSAVESIRTRLGTVPLPVQLPIGREDGFTGVVDLVRMRAYEWADGADTYTDLPVPDDLRDEALRRRRHLEETVAELHPGALDEFCERSALSEATLTGALRDLTLGGEAVVVLCGSAYRNRGVEPLLDAVVAYLPAPADMPPVRGEVPADPTAPFTALVFKVSATATGRMTYLRVYAGTLGKGDTVLDTTTGRTERIARVLRVQADRASEVDVARAGDIVAVVGPKSARAGATLCDPAAPVVLEPPTTADPVVSVAVEARRGTDTGRLATALARLSEEDPSLVVRSDPETGQTVLSGLGELHLEVAVEKLRRDRGLEVTVGRPQVAYRETVTKGVTGLLYRHVKQDGGAGQFAHVVIDVEPAPDGAEFAFSSVVTGGRVPQEYVRAVEAGCRDALVEGPLGGHPVTGVRVTLTDGATHPKDSSEMAFRTAGRFALREALRASVVTLLEPVADVTVTVPAESVGAVLGDLAARRGRVTDQTTRAGTAVVEATVPLAELFGYASRLRGRTQGRGTFTTRPAGYAPAP
>NZ_CP029196.1|WP_150162311.1|6084587_6084992_-|VOC-family-protein
MPSIALVTLVVRDYDEAIAFYTDALGFELVEDTDRGGGNRWVVVRPRGAAGVGGLGNAGLLLARAKNEAEEASVGNQTGGRVGFFLHTEDFARDHERMTAAGVKFMEEPRHEPYGSVAVFEDLYGNRWDLLQPA
>NZ_CP029196.1|WP_150162312.1|6085211_6085838_+|nucleoside/nucleotide-kinase-family-protein
MDVEQFDRLAARARALAEGRDRRVLGLAGPPGAGKSTLAERLVAHLGGRAVLVPMDGFHLAQAELERLGRAGRKGAPDTFDAAGYTALLARLRAPEPGTTVYAPAFDRSLEEPIAGAIPVGPEIPLVITEGNYLLHDAGVWAGVRPLLDEAWYLDLDDRRRVSRLVERHVRFGKDRARAERWVHDSDEANARLVAPGRARADLVVTLS
>NZ_CP029196.1|WP_150162313.1|6085851_6086598_-|hypothetical-protein
MNDTHTLPPRTPRIALVGDRSPHVRSHVRIPVLLDALAERDGLALDAYWIPTGDAAAPGAVRGFDAVWVLPGSPYESEAGALAAIRTAREDGVPFLGTCGGFQHALLEYARDVCGLTGAAHAENDPSADEGDLLIAPLACSLVGHEGVVRVTPGSLAERALGAERTTERYHCNYGPDSRHLDTLRAHGLRFTGADEEGGIRIAELPSHPFFLATLFQPELAGDGTRPHPLVRALAAAATRHAAGVSGT
>NZ_CP029196.1|WP_150162314.1|6086694_6087219_+|tetratricopeptide-repeat-protein
MTNDHDWEHRVAALWERIDAYEPADFRARVAALAAERPDDDPAALFEQGAAHDSTGQPEEAVRFYRRALDRRLSGLRRRRAVIQLASSLRNLGRPDRSVELLTAERAIPAEELDADEAALSGAVDAFLALALADTGRDREAASLALGALAPLLPRYNRSLAHYARALLTAPDGS
>NZ_CP029196.1|WP_150162315.1|6087229_6088111_+|LysR-family-transcriptional-regulator
MDPHLLRTYVTVARLASFSEAARALGYTQSAVSQHIAALEADLALPLLTRRPVAPTPAGERLLEHAGALLLRLDAARADLDRFAAAPRTTLSVAASPLALHPRTLAALPATGVTLRALPRERVPEAVATGDADAGLVDGIAAPSDPLRLPDVAPLTATPVAEEPLAVLLPAGHPLAGRPGLRLADLVDARWLDAPAAGVPLDELRSVHGGPAGRGFRTALRYEGTDTRALTALAAAGHGLALLPLPLAAGVPGAVGVPLVAPRLVHRTELLRPAGRVPAPTGPVARFTGRLGA
>NZ_CP029196.1|WP_150162316.1|6088160_6089120_+|hypothetical-protein
MAWWRRGPRRDGDDAPRDPEFAYFSQREAALFRGRVRETFAELGLEVTVYADHVIDDKGRRFGLGNLAAVCHQDRRGPRVWPGTIHRHIGLVVRAMEGPSALDTLPPEQIRSQLYPRVVSGEGIDAAAFGYARTVAPGLYEVLALDLPESVMMLTDEALRRLGDHTQLRDRALRNLRGLPVEEHETVRDADGMCFEIILGDSFYTASRVLDLDGVVRRVTGVPLGEHGALVAMPFRHQLAFHPIRDTSIIPALGAMASFAASGYEDTPGAISPYVFWWRGGTLTQLSEHDEERGDLRIVVGDDFQELLERLIAQGPDRR
>NZ_CP029196.1|WP_150162317.1|6089240_6090407_+|M24-family-metallopeptidase
MSSTPAPATEPGTASEAALPFTADDYRARMARAAESAADAGLAGIVVAPGPDLVYLTGYQPTAITERLTVLVLAAGQEPVLVVPTLEAPDAEKAAGAAALTLRDWTDGKDPYAVTAPLLDVDGRFGISDNAWAMHLLGLQQALPGTSYVSLTEALPMLRGVKDAHELARIAAAGAAADRAYGEILKVRFAGRKETDVAADLAGLLLRFGHSQVDFTVVGSGPNGANPHHEAGDRVIEHGDMVVLDFGGLKHGYGSDTTRTVHVGEPTDEERRVHDLVREAQQAGFEAVRPGVACQEVDRAARKVITDAGYGEYFIHRTGHGIGVTTHEPPYMIEGEELPIVPGMCFSIEPGVYLPGRFGVRIEDIVTATEDGAGRRFNNTPHEMALVE

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Crispr_ID: NZ_CP029196_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_22

6747413-6747477

Orphan

Consensus_repeat	Method
CGGCGGGCGTGACGGGCTCGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_22

>merge|NZ_CP029196|22|6747413-6747477|CRISPRCasFinder
CGGCGGGCGTGACGGGCTCGGCGAGCGACCCGGCGAGCGACCCGGGGGGCGCGAGGGGCCCGGCG

>NZ_CP029196|22|18|6747413-6747477|CRISPRCasFinder
CGGCGGGCGTGACGGGCTCGGCG	AGCGACCCGGCGAGCGACC
CGGGGGGCGCGAGGGGCCCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150162698.1\|6756514_6757903_-\|monooxygenase	unknown	unknown	gnl\|CDD\|223727
NZ_CP029196.1\|WP_150162690.1\|6735810_6736725_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP029196.1\|WP_150162687.1\|6729509_6731930_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|226702
NZ_CP029196.1\|WP_150162689.1\|6734572_6735691_-\|diaminopropionate-ammonia-lyase	unknown	unknown	gnl\|CDD\|236186
NZ_CP029196.1\|WP_150162701.1\|6760707_6761265_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162686.1\|6727961_6729431_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP029196.1\|WP_150162695.1\|6748585_6753346_+\|type-IV-secretion-protein-Rhs	unknown	unknown	gnl\|CDD\|225750
NZ_CP029196.1\|WP_015037691.1\|6761225_6761906_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|100107
NZ_CP029196.1\|WP_150162694.1\|6747508_6748120_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_CP029196.1\|WP_150163785.1\|6755517_6756375_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_CP029196.1\|WP_150163783.1\|6732041_6732473_-\|response-regulator	unknown	unknown	gnl\|CDD\|381108
NZ_CP029196.1\|WP_150162699.1\|6757973_6759374_-\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|378217
NZ_CP029196.1\|WP_150162688.1\|6732553_6734341_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP029196.1\|WP_150162697.1\|6753988_6755203_-\|sugar-hydrolase	unknown	unknown	gnl\|CDD\|185755
NZ_CP029196.1\|WP_150162691.1\|6736823_6738323_+\|DUF4246-family-protein	unknown	unknown	gnl\|CDD\|372885
NZ_CP029196.1\|WP_150163784.1\|6738474_6739260_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|225136
NZ_CP029196.1\|WP_150162696.1\|6753367_6753922_+\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|379650
NZ_CP029196.1\|WP_150163782.1\|6727142_6727790_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|172294
NZ_CP029196.1\|WP_150162700.1\|6759487_6760711_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238198
NZ_CP029196.1\|WP_150162692.1\|6739404_6742704_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173812

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150162698.1\|6756514_6757903_-\|monooxygenase	gnl\|CDD\|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	6.024e-10
NZ_CP029196.1\|WP_150162690.1\|6735810_6736725_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.71993e-43
NZ_CP029196.1\|WP_150162687.1\|6729509_6731930_+\|GAF-domain-containing-protein	gnl\|CDD\|226702	COG4251, COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms].	0
NZ_CP029196.1\|WP_150162689.1\|6734572_6735691_-\|diaminopropionate-ammonia-lyase	gnl\|CDD\|236186	PRK08206, PRK08206, diaminopropionate ammonia-lyase; Provisional.	4.82313e-109
NZ_CP029196.1\|WP_150162686.1\|6727961_6729431_+\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	1.627e-47
NZ_CP029196.1\|WP_150162695.1\|6748585_6753346_+\|type-IV-secretion-protein-Rhs	gnl\|CDD\|225750	COG3209, RhsA, Rhs family protein [Cell envelope biogenesis, outer membrane].	1.95942e-37
NZ_CP029196.1\|WP_015037691.1\|6761225_6761906_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|100107	cd02440, AdoMet_MTases, S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).	5.80092e-07
NZ_CP029196.1\|WP_150162694.1\|6747508_6748120_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	1.30667e-34
NZ_CP029196.1\|WP_150163785.1\|6755517_6756375_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	2.65803e-10
NZ_CP029196.1\|WP_150163783.1\|6732041_6732473_-\|response-regulator	gnl\|CDD\|381108	cd17557, REC_Rcp-like, phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains. This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	7.4492e-33
NZ_CP029196.1\|WP_150162699.1\|6757973_6759374_-\|DUF2029-domain-containing-protein	gnl\|CDD\|378217	pfam09594, GT87, Glycosyltransferase family 87. The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM. The family also includes alpha(1-->3) arabinofuranosyltransferase, invloved in the synthesis of of mycobacterial arabinogalactan.	0.000504355
NZ_CP029196.1\|WP_150162688.1\|6732553_6734341_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	3.59327e-39
NZ_CP029196.1\|WP_150162697.1\|6753988_6755203_-\|sugar-hydrolase	gnl\|CDD\|185755	cd09216, GH64-LPHase-like, glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like. This subfamily is represented by the laminaripentaose-producing, beta-1,3-glucanase (LPHase) of Streptomyces matensis and related bacterial and ascomycete proteins. LPHase is a member of glycoside hydrolase family 64 (GH64), it is an inverting enzyme involved in the cleavage of long-chain polysaccharide beta-1,3-glucans, into specific pentasaccharide oligomers. LPHase is a two-domain crescent fold structure: one domain is composed of 10 beta-strands, eight coming from the N-terminus of the protein and two from the C-terminal region, and the protein has a second inserted domain; this cd includes both domains. This protein has an electronegative, substrate-binding cleft, and conserved Glu and Asp residues involved in the cleavage of the beta-1,3-glucan, laminarin, a plant and fungal cell wall component. Among bacteria, many beta-1,3-glucanases are implicated in fungal cell wall degradation. Also included in this family is GluB , the beta-1,3-glucanase B from Lysobacter enzymogenes Strain N4-7. Recombinant GluB demonstrated higher relative activity toward the branched-chain beta-1,3 glucan substrate zymosan A than toward linear beta-1,3 glucan substrates. Sometimes these two domains are found associated with other domains such as in the Catenulispora acidiphila DSM 44928 carbohydrate binding family 6 protein in which they are positioned N-terminal of a carbohydrate binding module, family 6 (CBM_6) domain. In the Cellulosimicrobium cellulans, glucan endo-1,3-beta-glucosidase, they are positioned N-terminal of a RICIN, carbohydrate-binding domain.	1.87561e-174
NZ_CP029196.1\|WP_150162691.1\|6736823_6738323_+\|DUF4246-family-protein	gnl\|CDD\|372885	pfam14033, DUF4246, Protein of unknown function (DUF4246). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and fungi. Proteins in this family are typically between 392 and 644 amino acids in length.	2.10625e-173
NZ_CP029196.1\|WP_150163784.1\|6738474_6739260_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	1.91551e-25
NZ_CP029196.1\|WP_150162696.1\|6753367_6753922_+\|SMI1/KNR4-family-protein	gnl\|CDD\|379650	pfam14568, SUKH_6, SMI1-KNR4 cell-wall. Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.	0.000134648
NZ_CP029196.1\|WP_150163782.1\|6727142_6727790_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|172294	PRK13756, PRK13756, TetR family transcriptional regulator.	2.26558e-07
NZ_CP029196.1\|WP_150162700.1\|6759487_6760711_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|238198	cd00321, SO_family_Moco, Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Assimilatory NRs catalyze the reduction of nitrate to nitrite which is subsequently converted to NH4+ by nitrite reductase. Common features of all known members of this family are that they contain one single pterin cofactor and part of the coordination of the metal (Mo) is a cysteine ligand of the protein and that they catalyze the transfer of an oxygen to or from a lone pair of electrons on the substrate.	5.98378e-26
NZ_CP029196.1\|WP_150162692.1\|6739404_6742704_-\|S8-family-serine-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.27712e-70

>NZ_CP029196.1|WP_150162692.1|6739404_6742704_-|S8-family-serine-peptidase
MTGPTSAVTADTTAAPGTTRVGGDRRIPLVTGDRVVVDAKGRMVGFESAAGRERIPVQVRRVDDHTLVIPGDAERLIAAGRLDQRLFDLTVLTDARLRQSHRDGLKLIVRYADGAGTARTQVRAAGDTQLRRTLPGLDADAVRTPEDDVAKVWEALTDRRQGGARVAASGIASVWLDGVRTASLDRSVRQIGADKAWESGYDGKGVTIAVLDTGVDRTHADLATQVVAEKNFSVSSDAVDRVGHGTHVASIAAGTGATSGGRFKGVAPGAKVISGKVLDDEGFGDDSAVIAGMEWAAAEGADVVNLSLGSADSPGVDPLEATVDRLSAEKGILFAIAAGNEGEGGAATVGSPGSADAALTVGAVDKDDVLAPFSSTGPRVGDGAVKPDVTAPGVAITAAAAPGSAIDTRPGTPHPAPGYLQIDGTSMATPHVAGAAAILKQRHPEWKSAKLKGALTGSAKGGPYTAFQQGSGRVQIDRALTQSVVADPVSLNFGTALWPHADDKPLTRKVAYRNLGTTDVTLDLSVATLDPAGRPAPAGFFTLGAPKLTVPAGGRAEVDLVADTRLGDADGAYSGYVTATAPGQSVRTAAVAVREAESYDLTLRTVDRDGTDAETFTSTLYGVGGGAAGFASRVSDEPGSHTIRVPKGSYTFNTAVYQDPSDYTKGTDWIAQPKLDVTRDMTVVADARTAEPVDLTVPGRDTADYAGTYYEVATESGRVGNGWVLRGFTGFRTAHLGPAVTDGTLLQTWDAHFLKDATSQYSVAFGGKTDRVTTGYTRHVKADELATVKVGLGASVPGRTALASPFAHVPGAPEGNGFYAPQAAPGIRTFLVSTGDGVEWLTRYDQLGEPDQWGYPAFEGSWEMVRPKRYEAGRTYRETFHTGVVGPLLGEGMGVFRTAPDPATGEQQLIGAVPLFSDGKGHAGQSPSTSATSTLYRDGVKVGEHDDPLSGTRPFPVDAADAEYRLVASVERPAAAAAASTRIEAGFTFRSKQVTATTALPVSTVRFAPPVDLTSRAPHRAPVVVPVTVQGSAAGKNLKSLMVKVSYDDGATWQQVPVRNGAIAVRNPAKDGAISLSAAVTDKQGNVSTLTIHRAWLGK
>NZ_CP029196.1|WP_150163784.1|6738474_6739260_+|methyltransferase-domain-containing-protein
MWVTGEAYEPYVGRWSSQVAHRFVRWMGAAPRESWRDVGCGTGAVTRAVLDLADPATVVGLDPSAGFVAYARRTIADHRARFVLADAESLPFADSSASVAVSGLVLNFVPDPDRAAAEMARVVRPGGLVGAYVWDLGDGGMEIIRAFWDAASALDPEARALDEAVRFPLCARAPLGELFVRAGLEDVEVDGITVPARFVDFDDYWQPFLGAQGPAPAYVATLPEERRGALRERLRSALPRAEDGSIPLRARAWAARGRRPG
>NZ_CP029196.1|WP_150162691.1|6736823_6738323_+|DUF4246-family-protein
MTGLSAFPLPFHASRSIAFATPRSLRELQMMECSAHIRAKPGWFDKMNDADIVARWTREAVAQGLTEAQVRYVLDELAHYAALRDERTGIEVSGVDGVWHSDALVEDELRSRLRAAVRVLEEVPEAELDWHPGSDGQVLDLVHPSLFCLVREASGGPERAWQNPTNHYSKYEFSERFQWLPTDVDVDDEGEVAFRSYVNNLHPENHRELASVLPELFARFRPLLENVLTDLRTPRPPRIDVDPYGWYDDEPQRPDRSDYEDDQAYNEACRLQERALDDWWENRRPVVPDAPAFSAPEPPERIDLRGRRLQVIVKLATIHLTPDKPEYAGGSWHVEGMLNERIVSTGIYYWDNENITESRLSFRAALDDPEYEQSDDNGVREVYGLENEDALNQMLGSVSTPEGRCLAFPNILQHRVSPFRLADPTRPGHRKILAFFLVDPARTIVSTSDVPPQQPWSDTSTMTLEQAKEYREQLMRERKFFVDEHNEQLYEREFSLCEH
>NZ_CP029196.1|WP_150162690.1|6735810_6736725_+|LysR-family-transcriptional-regulator
MFDLHRLRLLRELKHRGTLAAVAAALSYAPSSVSQQLSQLEAEVGVPLLEPVGRRVRLTAQAEILVAHTEAVLERLERAEADIATSLTDLTGTLRIAAFQTAALALVPVALGLLRDLHPRLRVHVTQMEPERALPALQARDFDLVLAEEYPGNPNPRLAELEQEGLLDDPLRLALPGPADGADGPLAALRSLAGHPWAMEPEGTTARHWAVTLCRSAGFEPDVRFETTDLLLHLRLVEQGHAAAFLPELVWSGRRPTVPLRQLPRGQRSRRVFTVVRRGRSRHPAVLACRAALLRAAATSSGKG
>NZ_CP029196.1|WP_150162689.1|6734572_6735691_-|diaminopropionate-ammonia-lyase
MPDNASPSRALPWSVRPGARNWRCAPAPAGIRDFHSSLPDYAPTPLAERPSLAVELGVGRVFVKDESNRLGLPAFKALGASWAVHRTLAERAANGGRPAPVTLVTATDGNHGRAVARTARLLGQNAHVFVPRGVHPRAVAAIAAERARVTEVAGAYDEAVRLAAAAAAGPDAVLVQDTAWEGYERIPGWIVEGYSTLCVEIDEQLAAAGAGGPDLVAVPVGVGSLAQAVVTHYRSRRSGRPPALLAVEPEAAACVLESLALGEPVSVTTGPTTMAGLNCGTPSSIAWPYLHGGLDAAVAVPDAAGARASADLAALGVSSGPCGAAALAGIRAALNGAGAEERRTALGLGPASVVVLLSTEGRAANPQAEGAT
>NZ_CP029196.1|WP_150162688.1|6732553_6734341_-|SpoIIE-family-protein-phosphatase
MGGSGSEGATGSPGEQYWAERLHALWLAADVAHDVTGLADRVYDMLLSRPGVVSVVGTRWSGHRMTYLRLVSSEERTPITWRPPFSDWSEPVVRPGTTVALDGGAPVVLEHTGSGAAAALWPGGLVPAGRPVAALECAFPLAGDDWATLWVGLDRPAESTDPLHAQLVQVAEVLATSNVRLLAHHAHERRQVEDAFLAEASLQMDTSLDGDETLRRIARLAVPAVAEGCLVHLYNGAGVLRPVASAHVAAFAQGRLRELAEDDDWLVKLLRESSERRESTLVSAAELRDSPFGSVPGIGAVKSLSVTPLRARGRSLGTLTFLHHRAEAPVATPRLLGDLASRAALAIDTSTLYEKRRSHVEVLQRHLLPRTLPDVPGLRLSSAYRVADSSLDVGGDFYDAVAVGDDVALLIGDVCGRGAEAAAVTGLARHTLRTLLQEGTSPGIALTRLNDTLIAEGAARFVTALIALLSPARDGGWDVEIAVAGHPRPLVRRADGSVTEVDGAGALLGVIPGTAYRSVRVLLEPGASLVMFTDGLTEARGADGTFFEAGLPAAVAECSGGGPDPAGRLVAAASAFRHSGDDDTALLIATAEERP
>NZ_CP029196.1|WP_150163783.1|6732041_6732473_-|response-regulator
MDRGRVLVVEDSQEDAEAIERALARSHPHLVLEFLDRADQLVEHLTAGSALPGLILLDLNMPGTNGHTALASVRARPELSDVRVVVFTSSTSPAEEDACHVAGADSYIYKPVNFDLFRTVLKGAVDFWQDSPGPDGPAAPDGS
>NZ_CP029196.1|WP_150162687.1|6729509_6731930_+|GAF-domain-containing-protein
MTGWGGAEARPGTSGRRSRVAEEWLSRRARDAESAVPGGFDLSDCVREPIHLLGGVQSHGTLLAVEADGGVVDTAAANTLAVLGVPAEDLVGAHVTAVLSEEDWTDACRSVAEDGETSALQVEAGPVGAPRRFDLSLHRSGPFVVLEFEPRDEGLEFRFTGFYQGVRRALARLRSTVDVVDGCRAAVREIRALTGYDRVVAYRFDGPEGPGEVLAEDVTDAWEPWLGLWFPATDIPPQARRLYEENWIRVIGDVDDSTVGLVPPVRAGTGTPLDLSGAALRTVSGFHLEYLRNIGVRSSMSVSVMREGRLWGLIACHGAAPFHPAPEMRAACELFGAAFSLQLAAIEERERADALAGAAGRAASVAELLDADVEMSLPPHGGAVRDLVGADSAVLVRGARSVATGAPVPAALVTELRRRAGGMTPGTVWATDRLGELLADEGVHVPELDGGQAGVLLVRLTSPGDFLAWFRAERPTPRTWATDPATPVRVGPRGERLTPRGSSEVFRSVMRGRSLPWRPREQAAAAELGRMLTRLVLRHAEELAALNEELRMSNLDLDSFAHAAAHDLKEPLRGISNAATFTMEDAGAALDPTSVRRLLTIRRLAGRMDELLNSLLHYARLGQAGLRRVTVDLDEAVDAALEVAGPRLAEERVRVVRDTPLPHVEADPTRLYEILVNLLVNAAKYAAERPDRMVSIGVEEVPAECGGGADAGTAGTRPGRTERAVVVCDNGIGIPPELQADVFDLFRRLHGPAEHGGGTGVGLAVVKRIVERHGGRLWLESEPGSGTAFYFTLGEPPVPAGAGESG
>NZ_CP029196.1|WP_150162686.1|6727961_6729431_+|MFS-transporter
MTTATLTNPPRTYPSLRAAWIPLAALCLAFFVEMVDNTLLSIALPTIGRDLGGGTTALQWVTGAYSLTFGGLLLTAGSIADRLGRRRVLLIGLGVFGTLSLGVLLVHSAGGLIALRAGLGIAAAAMAPITNSLVFRLFDDKALRMRAMTVMIVVGMSGFVLGPLLGGTALAHVSWEWLLLVNAPIAVIACVGVRLGVPADRPQDLTKDSLDVPGAVLSVAAIGLACYSLTSGVEHGWLSTITLASVVGALAAALLFVRHERRTATPMLDLRLFSRGTVRGAALAQIGTSIAMASVMFGLILHFQYAYGWSPVRAGLANLPIIATMLLATPLSEWLARSFGHRVACLVGAGFLAGSLAGLAWGVEHGYAVIAVCMVLMTIGLRTVMTICAVALVDAMPANRTSIGAALNDTAQEVGSSVGTAVVGTLIAVLVTTQLPAGTWSGELIASFFHGERITYALLAVVVGLIAAGGALGLTDSRSVEEHPVEETA
>NZ_CP029196.1|WP_150163782.1|6727142_6727790_-|TetR-family-transcriptional-regulator
MESVLGEAVALLDEAGAPALTFRALAQRLGGGVASIYWYVANKDELLDLATDHVMAGVLADLDTLPPTQDPIDDLRAMALTLFDAVVRRPWLGAYFMRNTDVQSNSLRIYEMLGRQTLRLNLTARQRFHAVSAVIGVVVGSAIDMGQEPPQEVLDGAVNRDEFLGRFAQAWRELAPQDFPFIHDIVDEFDGHDDTDQFRSALDLTLAGLRLQAGL
>NZ_CP029196.1|WP_150162694.1|6747508_6748120_-|sigma-70-family-RNA-polymerase-sigma-factor
MNQRFRWPDEQLIRAAQDGDLTSLTTVVVESQPHVRKFALSLCASPQDAEDAAQEALIILYRKIGTLRASGALASWMFRIVRNECLRQVRLLVSRREEATPDMPEAETEPSAEEAVLRRQEVRRISAAIGALPRDQRQVLLMRDVQGLPGRAVAQALGLSNAAMKSRLHRARTTLRRSLEAPDRAPAPNPDPPAGGETRPWTP
>NZ_CP029196.1|WP_150162695.1|6748585_6753346_+|type-IV-secretion-protein-Rhs
MAVTVPDWADTLLDLVGVNWPNVDEDAYRDMADALREFADDLADDGQLANNHMERLLSSGHGEAMEALNEHWTKVKGKHLKDMVSAARTIADALDLAAGAIEGMKWKAVAELGVLAGQTGLALALIPVTGGLSALLGAGAIAFTKKQLLKLITEAMEEAVGHIVSVMTEPVVAALENMAADLVVQVSMDALGVQNGVDLDQTKQAGKDGLNLASAGGGGGGGGKGKGFHIEHDEHEQAGTKLNGVSTGIHGKTAGKLTKAKGHQRRNRGRDDIADALDPVIEKAMGALVKSAKTMGDHIGDTLPKAVKKISVDHKNNDDATRDRLARQRKGDHDDTKGGNGKPGPGGRGGDSDVRTRPNALRNARGDAQRNSIPLDKTHCEGDPIDVATGEMILAQTDLDLPGVLPLTLRRVHLSQYRYGQWFGRSWASTLDERLEVDPTGGGLIWAREDGSLLVYPRVPAAGDEAVLPVEGPRMPLSHSEEADARTTFRVTDPATGLCRYFTGDPYAVSTAYWLSEIEDRHGNGITFARRPDGSPSAVTHDGGYQVQITTDGSRITALALRTPAGPTTVLSYGYDEHGDLTGVTNSSGLPSRFTYDDDARITSWTDRNDSTFRYVYDSAGRVVETVGPDGIMSATLTYDHAVETDRITRYTDSTGATTAFRFDARYRLVAWTDPLGHTSTTAYDAHDRVVSATDPLGATVRIAYDDEGRPTTVTRPDGLVTSVSYNELGLPTTVTEPNGATWQHRYDEHGNRVALIDPAGASTTYTYNGRGAAIGITDPLGNTVTVDRDPAGLPTGLTDPTGAVTRCAYDAFGRLVDLTDPLGGHTRLTWSVEGALTSRTTADDRTERWTYDGEGNCLRHTDPSGRTTEFAYTHFDLPTEIRNPDGARISFRHDTERRLTGMTDAQGLTWGYSYDASGRLVAETDYDGGTTAYSYDAAGMLTGRTNALGQTTTYRYDTVGNLVEKDIAGHRVRYAHDPEGRLLRAESPDSVLEYAYDVVGRVVAETIDGRTVATTCDAAGRRLTRTTPSGTVTRQSYGEAGHRESLTVAGRTLRFTHDAVGRETSRTLDDVFRLAHTWNPVGRLEAQVLTPLTPAAPDPAAADSAAAPERRRERRYGWDPDGRLLAVTGSRATRRTFSLDGTGRVLAAEGPGWQESYAYDAAGNQRHASWPSAMPGAEATGERRYEGSRLVGAGTVRYAYDAQGRVVLRQKTRLSRKPDTWHYTWDAEDRLTAVTTPDGTRWRYRYDPLGRRVAKQRLAADGESVVEETLFSWDGSTLVEQTTRGADATEAVHLTWEHDGYRPLLQVESKSAADAPQDIVDQRFFALVTDLVGTPTEMVDETGHIAWHSRSTVWGVTVWNRDASAYTPLRFPGQYHDPETGLHHNYFRHYDPETARYLTLDPLGLDPGPNPFAYVDNPLTLQDPLGLKPCDESDPTWGGRVRFSTGPGGRSGTMRAKIEPGMTGGKTKPPTNVVGYQKYKGWNKTHLLGAQIGGSNKDTRNFVAMHRNANSPVMKAIEDQIRHAVDKNNETIDYTVTPIYRTNDPTDLVPVGLTIHATGNKGFRFIPYEGASPTNHITILNVPKP
>NZ_CP029196.1|WP_150162696.1|6753367_6753922_+|SMI1/KNR4-family-protein
MHPDVEQLTRIVPPPADRRPRAWTDVEARLGTALPEDFKDLVDTYGGGVFDETIWILEPDCADPDYDLLAMKQERAEVLARLWEIGPEPRPEQLEADGAGLLPFAYIEGTGAYLYWLTGKDVRPEDWTVLANAGRGPEWEYHPVPSTRFVLSVLTGEIHSDILDNLPVDDEDHSFDPNDEILGG
>NZ_CP029196.1|WP_150162697.1|6753988_6755203_-|sugar-hydrolase
MPARRRRARVARLVPLTAAAALIGTAVTLAGPSEPVEAAVPATIPLTFTNNSGRGDQVYVYNLGTELSTGRQGWADANGTFHPWPAGGPVPVPAPDAAITGPANGRSMTIRLPKFSGRIYFSYGQKLVFKVATGGLVQPAVQNPSDPNRDILFNWSEYTLNDSGLWINSTQVDMVSAPYAVGVKRPDGTVANTGRLKPGGYRGFFDALRGQPGGWANLVQTRADGTVLRALAPGHGIEAGALPSGVMSDYINRVWSKYATSTLTVTPFANQPSVKYFGRVSGNVMNFTNSSGAVVTSFQKPDSDSVFGCYKHLDAPNDQVRGPISRTLCAGYNRSTLLTNPNQPDTGPAGFYQDAVTNHYSRKIHAQMADGKAYGFAFDDVGAHESLVHDGSPQQAYVTLDPFN
>NZ_CP029196.1|WP_150163785.1|6755517_6756375_+|methyltransferase-domain-containing-protein
MTGGAPGDLGGDGIRDQGGGRYGEAVFRPEQAGEGDRIDYGAVAYDDITMARLRALGVGPGWRCLDVGAGTGTVSRRLLDEAGVAGVLAVDRDVRFLRERRVPGLDVLEADITGPGFVPGRRFRLVHARFVLMHLPEHDGLVARLAELVEPGGVLVLSDAVDLTSDRTPDTPYTVAMRAMWRGLKDTIGTDVSWVPSYPRVLRGAGLEAVAAEIHVPPLTPGSPLSRFWADTWERSRAAMLATGLVDDAAVDEAIRYLDSDACAALSAGMLTVWGHKPEGDGAPA
>NZ_CP029196.1|WP_150162698.1|6756514_6757903_-|monooxygenase
MTKQLPWGTAVVVGGSYAGLVTARVLADFFDEVVVLERDPVDGDTGSHPGAPQGYHAHAMLAKGGEVLEKLFPGLREELHEAGAPVFDYGERIDFLLPAGTAPRTRTGVRIQTFTRDELERRLRRRVLALPKVRMVAGVSCTGLVRDAQGRVGGVTYRESGEGRGGGEPDLARGRTTELAADLVVDASGRTSALTGWLGELGVTVPAQRTVKAKVTYTSMNFDRPEEGHPDYFVAYQMLFAPRVARAGVLLAVEGGRWTCSLLGFQEQPPTDDAGYLEFAHALDNPHLAEQIARRTAQEPTYRYTNVDNRWRPFHLVKDWPDRLVAVGDAVCVFNPVYGQGLTVAAMEAELLHGMLARQRAAGRPLDGIARDFQRRVGRLLLAPWTLSTNSDLMWDPRQRAVAARFAHWYNTRLFRVAVRDASVWARFVRVVNMTASPAVLFHPAVAAKVLTAGPGRGPGGR
>NZ_CP029196.1|WP_150162699.1|6757973_6759374_-|DUF2029-domain-containing-protein
MPRIRPVPAVVLTSLLLLALTAGLAALLRGDAGGGAFLGGYLGAWALFVAAVVTLRSAPARAVVPLVVAGAVAVAAVGLVAGPRTSTDSYRYAWDGRVQAAGISPYDHAPADPELRPLRDAWLFPGAAVCERGGSEFAPLGDGGCTRINRPAVHTVYPPVAEGWFLLVHVLSPADARHKGLQTGAALLALAVTGVLVAALRRRGDPRRAALWAWCPAVPVEAVDNAHVDVLAVLFSVAALLVVTRHRLAGGLLLGLAIASKLLPAVLLPGALSGVRRPRAALAVLAGAGATVGALYLPYVLLSRSSVLGYLGGYAQEEGYDDAGTGGRYVLLRLVLPDSWAPPVAALALAAVAVAVWWRGDPERPWRGALVTTGTAFLLLTPGYSWYALLLIALVALDGRGEWLGVAVAGAVAYLLGGDAATAAYAVAAALPAGAAWVRWRARARPDRRPVRPPRPLPVRRGRAPR
>NZ_CP029196.1|WP_150162700.1|6759487_6760711_+|molybdopterin-dependent-oxidoreductase
MTSRRTFRPHRRSPSSSPPRRRTPGAARSALSAVRPPVFTGRLHDARTATAVGRWLGAAFGVCFVTGLVSHYLQHPPDGLADDLPARPVWGYWLTQGLHVATGLAAIVLLLVKLWAVYPRLFAWPPVRSVRHALERLSVAVLVAAAVFELFTGLLNIAEWYPWPFSFIQVHFAVAWVVTGSILLHIAVKAPEIRDHWTRRSAGTLALPAEDATDRRSLLLGMGAAVGVVTLTTVGQTVPPLKALDLLAPRHPDHGPQGLPVNRTAAAAGVSASRLGAWRLEVAGPRPYTLTLDALRDMRQARARLPIACVEGWTVQADWGGVRVRDLVARAGGRPDRASLRVTSLELTGSYRVMEMGTDYVDDPLTLLALTLNGRPLSLDHGFPARIIAPNRPGVLQTKWVHRLEVR
>NZ_CP029196.1|WP_150162701.1|6760707_6761265_+|hypothetical-protein
MRNTDAQLVLRYALGGLGLGLIGLGAWLVAAEPDPAGVLLWLAGAVVLHDGVLAPLVLAVGLLIAARPARGLWRGALIVAGSVTLVTLPLLVRPGEPPNPSALPLPYGRNLAIVLGAVGVVTGVLYLVRGRGKLVRGRGDSVRGRGESVGRRREPRERREPPARGPEGGRDRGQGRGRERGGTGD
>NZ_CP029196.1|WP_015037691.1|6761225_6761906_-|class-I-SAM-dependent-methyltransferase
MSGATTWCADPYTDALRAGRGPLFLRRDDGWLLPLEVERWCEEPDAADRSVLGRCRGTVLDIGSGPGRLVAALAAEGRRALGIDISPEAVSRTERLGGAALCRSVFDPLPAEGRWDTALLIDGNAGIGGDPAALLRRLRQVVSRTGLVIAECAPVDVDERCEVRVDDGRGGRGTPFPWARVGTRALAAHAARTGWSVAEAWTVADRPFLSLLPRQSPVPPRSRPRP

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Crispr_ID: NZ_CP029196_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_23

6960722-6960808

Orphan

Consensus_repeat	Method
GGCGTACGACCCCGTGCCCCGGCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_23

>merge|NZ_CP029196|23|6960722-6960808|CRISPRCasFinder
GGCGTACGACCCCGTGCCCCGGCCCGTACGCCTGACGAACCGCCTCCCGGCCGGGCCTGGCGGCGTACGGCCCCGTGCCCCGGCCCG

>NZ_CP029196|23|19|6960722-6960808|CRISPRCasFinder
GGCGTACGACCCCGTGCCCCGGCCCG	TACGCCTGACGAACCGCCTCCCGGCCGGGCCTGGC
GGCGTACGGCCCCGTGCCCCGGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_015037887.1\|6952630_6952867_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_CP029196.1\|WP_150162836.1\|6955888_6956704_-\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|376667
NZ_CP029196.1\|WP_150162835.1\|6954801_6955872_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_CP029196.1\|WP_150162844.1\|6967401_6968646_-\|sugar-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
NZ_CP029196.1\|WP_150162834.1\|6954454_6954691_+\|30S-ribosomal-protein-S18	unknown	unknown	gnl\|CDD\|184031
NZ_CP029196.1\|WP_150162833.1\|6953265_6954417_+\|cobalamin-biosynthesis-protein-CobW	unknown	unknown	gnl\|CDD\|214844
NZ_CP029196.1\|WP_150163797.1\|6968642_6970214_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP029196.1\|WP_150162837.1\|6956928_6958209_-\|glycoside-hydrolase-family-6-protein	unknown	unknown	gnl\|CDD\|376532
NZ_CP029196.1\|WP_150162845.1\|6970276_6971386_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380649
NZ_CP029196.1\|WP_015037886.1\|6952325_6952631_-\|30S-ribosomal-protein-S14	unknown	unknown	gnl\|CDD\|181574
NZ_CP029196.1\|WP_015037908.1\|6971612_6972659_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380488
NZ_CP029196.1\|WP_150162846.1\|6973330_6975037_+\|ribulokinase	unknown	unknown	gnl\|CDD\|235221
NZ_CP029196.1\|WP_150163796.1\|6964093_6965146_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093
NZ_CP029196.1\|WP_015037888.1\|6953020_6953266_+\|type-B-50S-ribosomal-protein-L31	unknown	unknown	gnl\|CDD\|234969
NZ_CP029196.1\|WP_150162838.1\|6958302_6959268_-\|glycoside-hydrolase-family-6-protein	unknown	unknown	gnl\|CDD\|376532
NZ_CP029196.1\|WP_150162841.1\|6962471_6964034_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP029196.1\|WP_150162842.1\|6965142_6966141_+\|sugar-ABC-transporter-permease-YjfF	unknown	unknown	gnl\|CDD\|183235
NZ_CP029196.1\|WP_150162843.1\|6966258_6967326_+\|galactose-1-epimerase	unknown	unknown	gnl\|CDD\|185696
NZ_CP029196.1\|WP_150162839.1\|6959628_6960642_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224525
NZ_CP029196.1\|WP_150162840.1\|6961402_6962404_+\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380532

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_015037887.1\|6952630_6952867_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	2.85812e-32
NZ_CP029196.1\|WP_150162836.1\|6955888_6956704_-\|TSUP-family-transporter	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	1.09889e-13
NZ_CP029196.1\|WP_150162835.1\|6954801_6955872_+\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	2.42901e-173
NZ_CP029196.1\|WP_150162844.1\|6967401_6968646_-\|sugar-ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	1.07134e-136
NZ_CP029196.1\|WP_150162834.1\|6954454_6954691_+\|30S-ribosomal-protein-S18	gnl\|CDD\|184031	PRK13401, PRK13401, 30S ribosomal protein S18; Provisional.	1.04414e-30
NZ_CP029196.1\|WP_150162833.1\|6953265_6954417_+\|cobalamin-biosynthesis-protein-CobW	gnl\|CDD\|214844	smart00833, CobW_C, Cobalamin synthesis protein cobW C-terminal domain. CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression.	3.36833e-22
NZ_CP029196.1\|WP_150163797.1\|6968642_6970214_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP029196.1\|WP_150162837.1\|6956928_6958209_-\|glycoside-hydrolase-family-6-protein	gnl\|CDD\|376532	pfam01341, Glyco_hydro_6, Glycosyl hydrolases family 6.	1.19598e-78
NZ_CP029196.1\|WP_150162845.1\|6970276_6971386_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380649	cd19994, PBP1_ChvE, periplasmic sugar binding protein ChvE that interacts with a bacterial two-component signaling system. Periplasmic aldose-monosaccharides binding protein ChvE that belongs to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	3.77625e-157
NZ_CP029196.1\|WP_015037886.1\|6952325_6952631_-\|30S-ribosomal-protein-S14	gnl\|CDD\|181574	PRK08881, rpsN, 30S ribosomal protein S14; Reviewed.	2.86008e-46
NZ_CP029196.1\|WP_015037908.1\|6971612_6972659_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380488	cd01574, PBP1_LacI, ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators. The ligand-binding domain of LacI is structurally homologous to the periplasmic sugar-binding domain of ABC-type transporters and both domains contain the type 1 periplasmic binding protein-like fold. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the type 1 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	3.86201e-109
NZ_CP029196.1\|WP_150162846.1\|6973330_6975037_+\|ribulokinase	gnl\|CDD\|235221	PRK04123, PRK04123, ribulokinase; Provisional.	0
NZ_CP029196.1\|WP_150163796.1\|6964093_6965146_+\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	3.61298e-63
NZ_CP029196.1\|WP_015037888.1\|6953020_6953266_+\|type-B-50S-ribosomal-protein-L31	gnl\|CDD\|234969	PRK01678, rpmE2, type B 50S ribosomal protein L31.	1.02565e-49
NZ_CP029196.1\|WP_150162838.1\|6958302_6959268_-\|glycoside-hydrolase-family-6-protein	gnl\|CDD\|376532	pfam01341, Glyco_hydro_6, Glycosyl hydrolases family 6.	3.82112e-58
NZ_CP029196.1\|WP_150162841.1\|6962471_6964034_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP029196.1\|WP_150162842.1\|6965142_6966141_+\|sugar-ABC-transporter-permease-YjfF	gnl\|CDD\|183235	PRK11618, PRK11618, inner membrane ABC transporter permease protein YjfF; Provisional.	6.9899e-138
NZ_CP029196.1\|WP_150162843.1\|6966258_6967326_+\|galactose-1-epimerase	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	1.14439e-151
NZ_CP029196.1\|WP_150162839.1\|6959628_6960642_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.10466e-101
NZ_CP029196.1\|WP_150162840.1\|6961402_6962404_+\|substrate-binding-domain-containing-protein	gnl\|CDD\|380532	cd06309, PBP1_galactofuranose_YtfQ-like, periplasmic binding domain of ABC-type galactofuranose YtfQ-like transport systems. Periplasmic binding domain of ABC-type YtfQ-like transport systems. The YtfQ protein from Escherichia coli is up-regulated under glucose-limited conditions and shares homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily. Members of this group are predicted to be involved in the transport of sugar-containing molecules across cellular and organellar membranes; however their ligand specificity is not determined experimentally.	5.39813e-137

>NZ_CP029196.1|WP_150162839.1|6959628_6960642_+|substrate-binding-domain-containing-protein
MPHGVPNRQSTLDEVAELAGVSRSVASRVLNNAPHVSRAKREAVERAVHRLGYVPNPTARALATRQTGAAALVVSGEDPSIFADPFFAQVIVGASAALEEAELHLMLCLAASERGRRRVERLLRSKGADGVMLMALREDDPLARVAEEADIPVVFGGRPVGLDPRWYVDVDNLGGARAATEYLISLGRTRIATICGRLDTEVGRARYRGYQDAMLAAGLEPYPPEAGDFTEPSGAAAMAALSARHPELDGVFAASDNMGAGALRTLRDAGRRVPADVAVIGFDDLAVARISDPPLTTVHQPIEGLGREMARMLAALINGQAPTPLILPTRLVIRASA
>NZ_CP029196.1|WP_150162838.1|6958302_6959268_-|glycoside-hydrolase-family-6-protein
MRRRIRALVAALSALPLALVVAPSAHAADPTTMTSGFYTDPDSSAKKWVAANPGDGRAPAINTSLANTPMARWFGAWSGTIGTATGAYVGAADQQDKLPILVAYNIYLRDSCGGHSGGGAPSASAYATWIAQFAGGIAGRPAVVLLEPDSLADYGCLNQTQIRERQGMISGALAEFNRQSPNTWVYLDAGNPGWVSAATMAQRLHEAGLRQAHGFSLNISNYYTTDQNTAYGNAVNSELAARYGYTKPFVVDTSRNGKGSNGEWCNAAGRRIGTPTRLGGGAEMLLWIKAPGESDGNCGVGTGSTAGQFLPEAAYKMIYGY
>NZ_CP029196.1|WP_150162837.1|6956928_6958209_-|glycoside-hydrolase-family-6-protein
MNPRSLRRRTTAALAALAACAALIATQAQAQAAPVADALTPATRFYVDPNSKAAKQALTDLRNGDFANAVNMARLASWPQAEWFTEGTPDEVRAKVRSLVREARLVNRTPVLVAYNVPGRDCSQYSSGGAASSAAYRQWIDAFAAGIGDSKAVVVVEPDGLALLPSDCGPGVDPTGELTATRVADLTYAVRTLKAKARTTVYLDAGNVQWRPVGEMARRLLDAGVQHSDGFSLNVSNTHPTDHNTRYGTWISQCMWYATEGPEYARGHTDWCATQYYSPAAPNDGAPGNAVDPADPATWRWTDAWFDQNAGTPPNDALHHFVIDTSRNGLGAWTPEPGKYTGDPEIWCNAPGRGLGPRPTADTGVPLVDAYLWVKIPGESDGSCTRNTGGPIDPEYGIVDPPAGTWWPAQAHTLAHNAAPRLTFNH
>NZ_CP029196.1|WP_150162836.1|6955888_6956704_-|TSUP-family-transporter
MSTDLPLSPLRPPHSAPVVFGAGAAIGVLGGMIGLGGAEFRLPLLIGLFGFAALSAVILNKAMSLVVVLVALPARLTAVPAAEVAARWPVAVNLLAGSLLGAWAGASWAVRMRSTTLYKVLAALMVLMAAALVLTHTATLDTLDLPLRAQIPAGVVAGFGIGVVAAIMGVAGGELLIPTIVLLFGEDIKTAGSLSLLVSLPTMLVAFARYSRDGSFAVLGANLRFTAVMAAGSVTGAVLGGLLLGVFPDLVLIPALAVILLVSAVKLARHH
>NZ_CP029196.1|WP_150162835.1|6954801_6955872_+|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MGGPVVLGIESSCDETGAGIVRNGKLLAHVVASSMDEHARFGGVVPEIAARAHLQSFNPVVRQALDQAGLRLGQIDAVAVTTGPGLSGALQLGLAGAKSLAYAAGVPLYGVHHLAGHVAADTLEHGPLPTPCVVLIVSGGHTSLLLVRDLVREPILHLGDTLDDAAGECFDKVARILGLPYPGGPAIDRAARDGDPRAVHFPRPLTRGGDDPYAFSFSGLKTAAARWVEKHRLQGIDVPVADGAAALQEAVADVLSRKALAACKAYDVTTLIVVGGVAANSRVRALTEQRCAAAGVELRVPPMTLCTDNGAMIAAVGDLLVRSGVEPAPLDVSTDPSAPLEYASLTPLPAQLARAA
>NZ_CP029196.1|WP_150162834.1|6954454_6954691_+|30S-ribosomal-protein-S18
MTRRPEPRKPTKPRPNPLDAAGITYIDYKDTDLLRKFISDRGKIRSRRVTRVTARQQRRLAAAIKNAREMALLPYTTR
>NZ_CP029196.1|WP_150162833.1|6953265_6954417_+|cobalamin-biosynthesis-protein-CobW
MARDPRLPVVIVAGLHADARKEVVDRLLAAVPGSVALHHDLTGAPDGTVGRLIRDASGLLSEDATPLVNDCACCALREDLVPELERLAGAGLTRLAVVELWDSVEPKTMAEVVAAHAGDGLALTNVITAVDPALVLPYLGNGDDLAEGGLAAAPTDRRTVGDTFARQLEYAPVLALVDNEDADEEDHALLAQLHPTARRVTAGSDDLAAAAVAGFDVEAAAAAQHPACALLPQEADDAGVTTIVWHRGRPFHPGRLYEALEDLCCAAARSRGRFWLADRPDTLLAWDAAGGALCVESAGPWLASLPDAAWEMVPPMRRAAAAMDWHPEHGDRCQHLVFTSPGLDRDGLERLLESCLLTDEEYEAGPAGWKHLPAAFAPLLDTA
>NZ_CP029196.1|WP_015037888.1|6953020_6953266_+|type-B-50S-ribosomal-protein-L31
MKPGIHPAYGPVVFRDTASGSAFLTRSTLTSEKTIEWEDGRTYPVVDVEISSVSHPFYTGTARVLDTAGRVERFERRYGAR
>NZ_CP029196.1|WP_015037887.1|6952630_6952867_-|50S-ribosomal-protein-L28
MSAHCQLTGAKPGFGHTISHSHRRSPRRFDPNIQHKRYWLPSEGRHVRLTLSARAIKTVDAIGIEAAVARIRARGGKV
>NZ_CP029196.1|WP_015037886.1|6952325_6952631_-|30S-ribosomal-protein-S14
MAKQSKIAQNEKRKATVERYAARRAELKEIIRRPSSTAEERRAAREELSRQPRDASATRVRNRDSVDGRPRGYLRRFGLSRVRARQQAHAGYLPGVTKSSW
>NZ_CP029196.1|WP_150162840.1|6961402_6962404_+|substrate-binding-domain-containing-protein
MAHRALRVITAAVLAAGVLTACTTEPAPTGTTGGAGKGSSDGKLVLGFAQVGAESGWRTANTTSVREAAEKAGITLKFSDAQQKQENQIKAIRTFIQQKVDVIAFSPVVESGWDTVLKEAKSAGIPVILTDRAVDSQDTSLYRTFLGSDFVKEGQEAGKWLLKEYEGTSEPVNVVELQGTTGSAPANDRKAGFAEVIKGQPKFKVVASQTGDFTRAKGKEVMQAFLKSHKDIDVLYAHNDDMALGAIQAIEEAGKKPGTDIKVISVDGIKDAFVAMQEKKINVVVECNPLLGDQLMELAKKVAAGESVPRRVEVKEGVFTQDQAAAALPGRQY
>NZ_CP029196.1|WP_150162841.1|6962471_6964034_+|ATP-binding-cassette-domain-containing-protein
MTAPPVPTTPTRTDRPVLEALGIRRAFPGVLALDGVDLRLFPGEVHALMGENGAGKSTLIKVLTGVHPPDAGTVSVDGSPQRFAEPLEAQHAGISTVYQEVNLCPNLSVAENILIGREPRRLGLVHWAALHERAARLLTELDLDLDVRTPLSTHSLAVQQLVAIVRAVDVNAKVLILDEPTSSLDRDEVAQLFALVRRLRDRGVAILFVTHFLDQVFDLCDRVTVLRNGRLEGEYRIDELTPVTLVHRMVGSELRVLDELAETSHTGTTEGPGSGDTPFLSARGLARAGGVHPYDLDIHRGEVIGLAGLLGSGRTEAARLLFGADHADGGELRIDGERAALRSPRAAIAHKIAFCSENRKAEGLIGELTVRENIVLALQAARGWTRPLSRTRQEEIAARWIEVLDIRPAAPEAQVRNLSGGNQQKVLLARWLLTDPDLLILDEPTRGIDIGAKTEIQKLVTRLAADGTAVLFISAELEEVLRLSHRVGVLRDHRLVATLANDPTLTPDRILGAIATGATS
>NZ_CP029196.1|WP_150163796.1|6964093_6965146_+|ABC-transporter-permease
MIEHRLFWPAAVLAALLAGNVVFTHDFLAVRVQNGHLYGSLIDVLQFGAPLILVSLGMTLVIATRGIDLSVGSTVAIAGALACEHIATAKDPGSVSTVLSAIAVAVGVAAGIGLLNGFLVARLGVQPIVATLVLMVAGRGVAQLITDGQIISVSSGAYKMIGGGYWLTLPFAVLLAAALVAVTSLVTRRTALGLLIESVGGNPVASRLVGIRAAGLLVMVYVVSAVCAAVAGLMISSNVSSADGNNAGLWIELDAILAVVIGGTALTGGRFSLGGTVLGALTIQTLSTTIYTLGVPPETTLVFKALVVIVVCLVQSPAFRARLSRRRRTAAPDPASATDDLTARRQEVHP
>NZ_CP029196.1|WP_150162842.1|6965142_6966141_+|sugar-ABC-transporter-permease-YjfF
MSTTLTKPLHRFSARHAARLPLMVTATLLVAMFSIGSVQYEGFFSAQVLLNVLIDNSFLLVVAIGMTFVVLTGGIDLSVGSTVALSTMLTAWLVEQNGLPLALAVPVVLLVGAGGGALMGWVIHAFEIQPFIVTLAGMFLARGLCYMISTKSISVTDPTTTRIAQTRVLLPGGLFVSPAVIIALVVLAVAFVVLHHTRFGRTVYALGGNESSARLMGLPVGRTKVAVYAVSGLCSALGGLLLTFYMLSGNALHAVGMELDAIAAAVIGGTLLTGGSGFVLGTALGVTVLGLIQTIISFQGTLSSWWTRIVIGGLLFVFILLQRLFAGPRQAE
>NZ_CP029196.1|WP_150162843.1|6966258_6967326_+|galactose-1-epimerase
MNPAPSTFTGVPPVCRPDPHAGQRWTFGFPGGLTAEVHTRGARLHGLWVPDRNGTPADVVLAPHDPARAADTARYFGSTVGRYANRIAHGRFSLDGKPYQLTTQENGHCLHGGTDGFDTRLWGAEGVHTPEWTGVLLRLRSPDGDQGFPGNLDVTVSVLIGRDDELAFTYRAVTDAATPVNLTNHAYFNLDGEGAGDILGHELAVHASHYTPVDDDLLPHGDHRPVAGTAFDLRRPLRIADALARPGPDGGYDHNFVLSPQGDDTLRRAAVLHSPSTSRRMEVLTTEPGLQVYTAGQFDGTVLGKSGTPYGAGAGIALETQHFPDSPNRPGDPSTVLRPGEEYRSRTVLRFGTGG
>NZ_CP029196.1|WP_150162844.1|6967401_6968646_-|sugar-ABC-transporter-permease
MSTDVSTKSTTPAPPGRGAPSTGAPLARVLLNGVRRNMRQYGMLVALALIVLLFQIWTGGDLLLPRNVSNLVLQNSYILILAIGMMIVIISGHIDLSVGSLMALVGGIGAVLMVQHHVAWPVAVLLTLLLGAVAGALQGFFIAYVGIPSFIVTLAGMLLFRGLTEIFLKGQTLGPFPDGLQKVANGFLPEVGPETNYHNGTLLLGLGLVAYVVFQEVRDRRRQRAFALEPLPTGLFALKLTALVAAVVVTTLLLASYKGAPVVLLILAALLVGFGYVMRNAVIGRHVYAIGGNLPAAKLSGVKDKKVTFAVFLNMGMLAALAGLVFAARFNAASPKAGVNFELEAIAAAFIGGASMSGGVGTVLGAIIGGLVLGVLNNGMNLVGVGTDWQQVIKGLVLLAAVGFDVWNKRRAGA
>NZ_CP029196.1|WP_150163797.1|6968642_6970214_-|ATP-binding-cassette-domain-containing-protein
MRSIVKTFPGVRALSDVTLSVERGEVHALCGENGAGKSTLMKVLSGVHPHGTYEGEILFEGEPCRFKDIRASEQRGIVIIHQELALVPYLSIAENVFLGNEPSRRGVIDWNEALRRASELLRRVGLDEHPETRVADIGVGKQQLVEIAKALAKDVRLLILDEPTAALNDEDSAKLLRLMRELKSQGITSIIISHKLNEIARIADSVTILRDGRSIETLDVRDPATTEERIIRGMVGRDLDSRFPDRTPYEGPADAGPVLEIRDWTVRHPLDRGRKAVDGVSLQVRRGEIVGVAGLMGAGRTELAMSVFGRSYGHYERGTVLKDGREVRTRTVPEAVAHGIAYVTEDRKHYGLNLGDSVSRNISLASLGALARRGVVDGHEERKVAERYRRTMNIKAPNVLEPVGRLSGGNQQKVVLSKWILAGPDVLILDEPTRGVDVGAKFEIYTVIDRLAAEGKAILLISSELPELLGMCDRIYTMAAGRLTGEVAREDATQEVLMRHMTQDTPAPPAVTAGAASSEGHQA
>NZ_CP029196.1|WP_150162845.1|6970276_6971386_-|substrate-binding-domain-containing-protein
MKKFRSASALLAVTTGCALLLTACGQNSEGGSQESKDTKDLTIGIAMPTKSSERWIADGRNMTESLKKAGFATTLQYGEDDPDQQVAQIENMITQGVDALVVAAINGEALSNVLQQAADAHIPVISYDRLILGSPHVDYYASFDNEKVGELQATYIVEKLGLKAGSKKGPFNIELFAGSNDDNNTKYFFNGAMKVLKPYLDKKQLVVRSQQTQLNQVTTLRWDGGTAQKRMDDLLTSAYSSARVDAVLSPYDGISIGILSALKSDDYGSAAKPLPVVTGQDAEVASVKSIIAGQQTQTVYKDTRALAQVAADMVTAVLAGKKPQINDDATYDNGKKVVPAFLLDPVSVDKSNYRKVLVDSGYIKAEELR
>NZ_CP029196.1|WP_015037908.1|6971612_6972659_+|LacI-family-DNA-binding-transcriptional-regulator
MAHPAEDVRPPTMADVAREAGVSHQTVSRVLSDHPNVRAATREQVTLAIERLGYRRNSAARALVTRRTRTLGVIAVNTALYGPASTLTGLEEAAREQGYLVSTVSLRTGEGQGLKDAIDHLASWGVEGVVAITPQRSHVQALAELDAPFPVVTVEGGHQLDLPGVSLDQELGARMVTEHLLAAGHGNVWHVAGPDDWLESEARTAGWRTVLEESGIRPPRVLTGDWSPLSGYRAGQELAGLALARRGATPVTAVFVANDQMALGVLRALREGGIRTPGQVAVAGFDDIPEAEFFPPPLTTVRQDFAAIGRRSIGLLVDHIEGRARKAEHLLVEPQLIMRASTRPSNES
>NZ_CP029196.1|WP_150162846.1|6973330_6975037_+|ribulokinase
MTTHTPSGPAAPQHPEACTIGVDFGTLSGRAVVVRVRDGAELGSAVHEYRHAVIEDHLPSTGAPLPPDWALQHPEDWRDVLRTAVPAALADAGVDPDRVIGIATDFTACTVLPTTPDGTPLALTPEWADRPHAWPKLWKHHAAQEQADRINALAHARGEKWIARYGGKISSEWQYAKALQLLEEDPAVYAACARWIEAADWIVWQLTGTESRNTCTAGYKGIHQDGTYPSPAFLAGLHPDFADFPATRLEHPLSPLGSRVGTLSSRAAHWTGLPEGIAVAAGNVDAHVAAPAAGAVENGRMLAIMGTSTCHVLNGATLAEVPGICGVVDGGIVEGAYGYEAGQSAVGDIFAWWLRQGVPDHYRAEAEASGEDLHRLLTRKAADQPVGAHGLVALDWMNGNRSTLVDHHLSGVIAGLTLDTRPEDVYRALLESTAYGTRMIVETFEGGGIPVEEFIVTGGLKKNALLMQIYADVLRRPVSVGTSEQGPALGSAIHAAVAAGAYPDVRSAASVMGSVQRHAYVPDPARADAYDALFQEYRALHDHFGTGADLLLHRLRRIRNTARLVATG

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Crispr_ID: NZ_CP029196_24

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029196_24

7163781-7163873

Orphan

Consensus_repeat	Method
CCACCCCGGGTCCCTCCACCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029196_24

>merge|NZ_CP029196|24|7163781-7163873|CRISPRCasFinder
GCACCCCGGGCCACTGCGCCGCCCACCCCGGGTCCCTCCACCGCCGTGGGGCGGAGCGGGACCGGCCCGACCACCCCGGGTCCCTCCACCGCC

>NZ_CP029196|24|20|7163781-7163873|CRISPRCasFinder
GCACCCCGGGCCACTGCGCCGCC	CACCCCGGGTCCCTCCACCGCCGTGGGGCGGAGCGGGACCGGCCCGA
CCACCCCGGGTCCCTCCACCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029196.1\|WP_150162971.1\|7156129_7157005_+\|GvpL/GvpF-family-gas-vesicle-protein	unknown	unknown	gnl\|CDD\|377652
NZ_CP029196.1\|WP_015038050.1\|7166305_7167631_-\|ergothioneine-biosynthesis-protein-EgtB	unknown	unknown	gnl\|CDD\|274581
NZ_CP029196.1\|WP_150162979.1\|7167627_7168887_-\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	unknown	unknown	gnl\|CDD\|274583
NZ_CP029196.1\|WP_041663218.1\|7173535_7173763_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162984.1\|7173777_7174485_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166
NZ_CP029196.1\|WP_150162980.1\|7169135_7169966_+\|TIGR02452-family-protein	unknown	unknown	gnl\|CDD\|131505
NZ_CP029196.1\|WP_015038043.1\|7159839_7160058_+\|dodecin-domain-containing-protein	unknown	unknown	gnl\|CDD\|377810
NZ_CP029196.1\|WP_015038039.1\|7157001_7157283_+\|gas-vesicle-protein	unknown	unknown	gnl\|CDD\|376379
NZ_CP029196.1\|WP_150163810.1\|7157867_7159079_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340817
NZ_CP029196.1\|WP_150162974.1\|7160140_7161181_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238119
NZ_CP029196.1\|WP_150162973.1\|7159160_7159652_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319805
NZ_CP029196.1\|WP_150162982.1\|7171091_7171817_-\|dienelactone-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|223489
NZ_CP029196.1\|WP_150162972.1\|7157279_7157732_+\|gas-vesicle-protein-K	unknown	unknown	gnl\|CDD\|377462
NZ_CP029196.1\|WP_150162981.1\|7170372_7170726_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029196.1\|WP_150162975.1\|7161473_7162724_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP029196.1\|WP_150162976.1\|7162862_7163738_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379189
NZ_CP029196.1\|WP_015038049.1\|7165553_7166306_-\|ergothioneine-biosynthesis-protein-EgtC	unknown	unknown	gnl\|CDD\|132483
NZ_CP029196.1\|WP_150162983.1\|7172035_7173451_-\|flotillin-family-protein	unknown	unknown	gnl\|CDD\|259798
NZ_CP029196.1\|WP_150162970.1\|7155605_7156133_+\|gas-vesicle-protein	unknown	unknown	gnl\|CDD\|376379
NZ_CP029196.1\|WP_150162978.1\|7164591_7165557_-\|L-histidine-N(alpha)-methyltransferase	unknown	unknown	gnl\|CDD\|378355

Protein	Function_ID	Function_description	E-value
NZ_CP029196.1\|WP_150162971.1\|7156129_7157005_+\|GvpL/GvpF-family-gas-vesicle-protein	gnl\|CDD\|377652	pfam06386, GvpL_GvpF, Gas vesicle synthesis protein GvpL/GvpF. This family consists of several bacterial and archaeal gas vesicle synthesis protein (GvpL/GvpF) sequences. The exact function of this family is unknown.	6.81938e-44
NZ_CP029196.1\|WP_015038050.1\|7166305_7167631_-\|ergothioneine-biosynthesis-protein-EgtB	gnl\|CDD\|274581	TIGR03440, egtB_TIGR03440, ergothioneine biosynthesis protein EgtB. Members of this family include EgtB, and enzyme of the ergothioneine biosynthesis, as found in numerous Actinobacteria. Characterized homologs to this family include a formylglycine-generating enzyme that serves as a maturase for an aerobic sulfatase (cf. the radical SAM enzymes that serve as anaerobic sulfatase maturases). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	4.10674e-160
NZ_CP029196.1\|WP_150162979.1\|7167627_7168887_-\|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA	gnl\|CDD\|274583	TIGR03444, EgtA_Cys_ligase, ergothioneine biosynthesis glutamate--cysteine ligase EgtA. Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	1.28244e-118
NZ_CP029196.1\|WP_150162984.1\|7173777_7174485_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.13545e-14
NZ_CP029196.1\|WP_150162980.1\|7169135_7169966_+\|TIGR02452-family-protein	gnl\|CDD\|131505	TIGR02452, conserved_hypothetical_protein, TIGR02452 family protein. Members of this uncharacterized protein family are found in Streptomyces, Nostoc sp. PCC 7120, Clostridium acetobutylicum, Lactobacillus johnsonii NCC 533, Deinococcus radiodurans, and Pirellula sp. for a broad but sparse phylogenetic distibution that at least suggests lateral gene transfer.	1.08985e-106
NZ_CP029196.1\|WP_015038043.1\|7159839_7160058_+\|dodecin-domain-containing-protein	gnl\|CDD\|377810	pfam07311, Dodecin, Dodecin. Dodecin is a flavin-binding protein,found in several bacteria and few archaea and represents a stand-alone version of the SHS2 domain. It most closely resembles the SHS2 domains of FtsA and Rpb7p, and represents a single domain small-molecule binding form.	6.20495e-30
NZ_CP029196.1\|WP_015038039.1\|7157001_7157283_+\|gas-vesicle-protein	gnl\|CDD\|376379	pfam00741, Gas_vesicle, Gas vesicle protein.	7.56317e-11
NZ_CP029196.1\|WP_150163810.1\|7157867_7159079_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	8.51718e-48
NZ_CP029196.1\|WP_150162974.1\|7160140_7161181_-\|VWA-domain-containing-protein	gnl\|CDD\|238119	cd00198, vWFA, Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.	1.69265e-08
NZ_CP029196.1\|WP_150162973.1\|7159160_7159652_+\|hypothetical-protein	gnl\|CDD\|319805	cd07502, HAD_PNKP-C, C-terminal phosphatase domain of T4 polynucleotide kinase/phosphatase (PNKP) and related phosphatases. This family includes the C-terminal domain of the bifunctional enzyme T4 polynucleotide kinase/phosphatase, PNKP. The PNKP phosphatase domain can catalyze the hydrolytic removal of the 3'-phosphoryl of DNA, RNA and deoxynucleoside 3'-monophosphates. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.17052e-49
NZ_CP029196.1\|WP_150162982.1\|7171091_7171817_-\|dienelactone-hydrolase-family-protein	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.40464e-35
NZ_CP029196.1\|WP_150162972.1\|7157279_7157732_+\|gas-vesicle-protein-K	gnl\|CDD\|377462	pfam05121, GvpK, Gas vesicle protein K. These proteins are involved in the formation of gas vesicles.	3.537e-34
NZ_CP029196.1\|WP_150162975.1\|7161473_7162724_+\|extracellular-solute-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.73072e-95
NZ_CP029196.1\|WP_150162976.1\|7162862_7163738_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379189	pfam13444, Acetyltransf_5, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions.	3.09645e-48
NZ_CP029196.1\|WP_015038049.1\|7165553_7166306_-\|ergothioneine-biosynthesis-protein-EgtC	gnl\|CDD\|132483	TIGR03442, TIGR03442, ergothioneine biosynthesis protein EgtC. Members of this strictly bacterial protein family show similarity to class II glutamine amidotransferases (see pfam00310). They are distinguished by appearing in a genome context with, and usually adjacent to or between, members of families TIGR03438 (an uncharacterized methyltransferase) and TIGR03440 (an uncharacterized protein). [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	9.08947e-105
NZ_CP029196.1\|WP_150162983.1\|7172035_7173451_-\|flotillin-family-protein	gnl\|CDD\|259798	cd03399, SPFH_flotillin, Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.	5.76959e-41
NZ_CP029196.1\|WP_150162970.1\|7155605_7156133_+\|gas-vesicle-protein	gnl\|CDD\|376379	pfam00741, Gas_vesicle, Gas vesicle protein.	8.38802e-17
NZ_CP029196.1\|WP_150162978.1\|7164591_7165557_-\|L-histidine-N(alpha)-methyltransferase	gnl\|CDD\|378355	pfam10017, Methyltransf_33, Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.	3.66914e-158

>NZ_CP029196.1|WP_150162976.1|7162862_7163738_+|GNAT-family-N-acetyltransferase
MAAPTPTLAVPAPTPTLAVPAQPRPLAGPPAPQAPVAPSASPAAAAEPTPRYLVGLARDQEDVRAAQRLRHQVFAGELGARLDGPEPGLDSDAFDAYCDHLLVREETTGEVVGTYRILPPDRAAVAGRLYSESEFDLTRLAPIRHDLVEVGRSCVHPAHRNGAVIALIWAGLARYMTTTGHNWLAGCCSLPLADGGTLAAATWDTVKAKHLAPEEYWVTPHKLWNPEGITRPEGRTELPPLLRGYLRLGAWVCGAPAHDPDFGVADLYVLLSLRRTNPRYLNHFLSLAPAR
>NZ_CP029196.1|WP_150162975.1|7161473_7162724_+|extracellular-solute-binding-protein
MKNRHLACPLAAATALALAGCGMLPGGGGGTKTVNIWLMRDSVSEDFLNRFTEAYEDEHDGVELKVTVQEWTGIGKKVTEAIQGSGGPDVIEVGNTQVAQYADTEKLYDLTLESVRDLGSEDWLPGLAEPGSIGGSQYGIPWYAANRIVIYNKDLFADAGIDKPPATRAEWLADTEKLNRKGNQGIYLAGQDWYTLAGFIWDEGGELATDKGGEWTGALDSPAARRGMAYYKQLQSLGSGPKDADEQNPPQADVFAKGDVAQLIAVPSAVSAILKANPALKDKLGYFPIPGAKADQPCAVFTGGSDLIIPENAPERGAALDVVKALAGEKWQTELARAMGYVPNKRGLASVVAGQEATAVMARGAARGRATPNSPQWADVEADNPIKPYMTAVLQGEDPAKAAQQASTAITETLAE
>NZ_CP029196.1|WP_150162974.1|7160140_7161181_-|VWA-domain-containing-protein
MSGTQNYINHVALVLDASSSMSHLSSKVVDVADRQIAYLARRSRELDQETRVTVYVFADKVECVIYDKDVLRMPSLKQLYRVGGMTALLAAALKSQRELAQTAQLYGDHSFLTFVLTDGQENASHRCPDAPTKDPRALVEAVARMIETQQDNWTLAVLVPDQMGKREAMQSGFPKDNIAIWDATSTQGLEEAGQVIQEATEKFMVGRTKGIRGSRAVFSTGADAVNADTVKAAGLAPVDPAEYQLIPVARDAAIRDWVVESGHTYRTGGAYYQLSKPEKIQARKRIAVLEKKTDRVYTGPEARTLLGLPDVEARVRPDHNDEFTIFVQSTSVNRKLVTNTRLLLML
>NZ_CP029196.1|WP_015038043.1|7159839_7160058_+|dodecin-domain-containing-protein
MGDHVYRVTEIVGSSSEGVDTAIRNGITRACETLRSVDWFEVTEIRGHVEEGQVAHFQVGMKVGFRLEEPGT
>NZ_CP029196.1|WP_150162973.1|7159160_7159652_+|hypothetical-protein
MTADNHRPLAVFDLDNTLAATAHRQHFLERRPKDWDAFFAAAPDDPPLDEGIALCLEAAGECDIVYLTGRPERCRRDTLDWLAAQGLPEGPVHMRRNRDFRPARVTKVEILRRLGADRPVRMLVDDDLLVCDAAEAAGFPVVRARWATPSEELRDAQEKEGRT
>NZ_CP029196.1|WP_150163810.1|7157867_7159079_+|glycosyltransferase-family-1-protein
MTAGSRGDVAPYTGLGAGLVRAGHEVTLAAHGVFEPLVAGSGVRFRALPVDPRAELHSPRGRRLHDARTGAGKLVRLASMARSAADEMTAALVEVAREGDVLLVGGALGPLGYAIADGLSVPAMGLHLQPLHPTGEFPAPVLGTRSLGAVGNRLSGRAVMTTVELLFADAVRSLRRRYGLVSTGPRRGRRARPVLHGYSRLVVPRPRDWPPELEVAGYWWPHETGRLSQELEDFLAAGPPPVFVGLGSATVPDPERVSREIVTALRTANVRGIVQRGWAGLDARSDDILTVDEVPHSLLFPRTAAVVHHAGAGTTGAVLRAGVPSVPVPVQFDAAFWASRLTALGTAPGAVPLRRLTSGALSEALVGATADGRHRARARALADRLAAEDGVAPVLAALARLAP
>NZ_CP029196.1|WP_150162972.1|7157279_7157732_+|gas-vesicle-protein-K
MNGPGPAPGERGGDPRTSPPPRTPSPALEGVGTALGDAFRLVKAPPDPAGEPHRPAHRLRTGRDSVEEDLLKLVLTVVELLRQLIERQALRRVDAGDLTDDQEEELGATLMALHDALSDLCAEHGYTLQDLNLDLGPLGPLLPPADRGPG
>NZ_CP029196.1|WP_015038039.1|7157001_7157283_+|gas-vesicle-protein
MSVDRSTEQLPGRQVALVDLLDRLLSGGVVLSGDIVLSIADIDLVRISLRALIVSVGSEADPLGPSAQRHTGPLGPSAHGRADPLGPTAQGLA
>NZ_CP029196.1|WP_150162971.1|7156129_7157005_+|GvpL/GvpF-family-gas-vesicle-protein
MTGGENLTYVYAVVADSPELRTVLSGVHGVSGAPVSLLGEDTPATTPTGPDPAFVISRVTAREYDERTLKARFEDLEWLEAVARAHHEVVQTIARHDTVLPLRLATLYQDDDRAREALAARRGVFAERLALLQGRSEWGVKVYVSSAGPPQDGAAAGPASTTTLGPGKAYLRRRRAQHTVQETHYRNAQAAAENIEALAARYTTHRVRHPAQRGALAGPEENVLNDAYLVPDGRAQSFRTALAAVAVDIDGVRVEVTGPWAPYSFAMPPPPSDPPPSAPPQEDAARDGPAP
>NZ_CP029196.1|WP_150162970.1|7155605_7156133_+|gas-vesicle-protein
MSDPLPDRFGTAPSRAMPAPYGSGSSANLADILERVLDKGIVIAGDIRINLLDIELLTIKLRILVASVDKAKEMGIDWWEHDPSLSSKHSGGPLAEENRRLRAELDALRRAAPIANEPRIPGTEQAVDPEALEPDDYEEAGGGYEEPGEPEAPGEQRSDPSSTSRRKAARRRPGT
>NZ_CP029196.1|WP_150162978.1|7164591_7165557_-|L-histidine-N(alpha)-methyltransferase
MSPFQLTRTLAPDAAGADLRADVLHGFHRSPKELPPKWFYDARGSELFEEITRLPEYYPTRAEREILKERAAEIAAATGARTLVELGSGSSEKTRFLIDALLPGLDSYVPVDVSESALTGAAEALLAARPELRVHALVADFTRGLALPGTPGPRLVAFLGGTIGNLLPGERRTFLRSVRAMLTPGDALLLGTDLVKDEATLVAAYDDDAGVTAAFNKNVLAVIDRELGADFDPDAFEHVAVWDREREWIEMRLRARRALTVKIPELDLVVPFAAGEEMRTEVSAKFRQAGVRAELAEEGLDLERWWTDSEGRFALSLATAR
>NZ_CP029196.1|WP_015038049.1|7165553_7166306_-|ergothioneine-biosynthesis-protein-EgtC
MCRHVAFVGEPVALGELILRPEHGLLRQSWAPRTQNSGVVNADGFGVGWYAEGDPVPARYRRTGPIWSDLSFTDLARVVRSGALLAAVRGATVPGADGEAAAAPFAAGPWLFSHNGAVTGWPGSLEALAGTLSAGELLRVEARTDSALLWALALHRLRSGDAPGPALADTVREVAEAAPGSGLNLLLTDGSLIAATAWGNSLWYLRGPDRVVVASEPYDADPRWQEVPERTLVTATRADVTLTPLKEPSA
>NZ_CP029196.1|WP_015038050.1|7166305_7167631_-|ergothioneine-biosynthesis-protein-EgtB
MTETRTDAGPEALRRRAVAALTAARERTALLTSCVEDGELTAQHSPLMSPLVWDLAHIGNQEELWLWRAVAGREALRPEIDSLYDAFEHPRATRPSLPLLAPGEARTYAADVRLRVLDVLERAEFDGRPLLRDAFAFGLVAQHEQQHDETMLITHQLRKGPAVLTAPPPPAGPRDPLPAEVLVPGGPFTMGTSDEPWALDNERPAHIRDVPAFHIDTVPVTNGAYLAFIADGGYEERRWWRPEGWAQIREHGIAAPLFWRRDGAQWLRRRFGVTEPVPEDEPVLHVSWYEADAYARWAGRRLPTEAEWEKAARHDPASGRSRRYPWGDADPRPEHANLGQRHLRPAPAGSYPEGASPLGVRQLIGDVWEWTASDFLPYPGFTVFPYKEYSEVFFGPDHKVLRGGSFGVDPVACRGTFRNWDLPVRRQIFAGFRTARSAELD
>NZ_CP029196.1|WP_150162979.1|7167627_7168887_-|ergothioneine-biosynthesis-glutamate--cysteine-ligase-EgtA
MSSSGIPRGGPPLAEAEAEELLRCICFKTGPPRTVGVELEWLVHELRDPRLPVRPPRLAAALDTVRSLPLVSALTFEPGGQLELSSRPAGSLMECLDSVAADLRAVRSALGPLGLTLSGYGVDPWHAPRGRVLHEPRYDAMEAALDRTGPAGRAMMCDSASVQICLDAGHEEPGPLGYHRRWQLAHLLGAVLVAAFANSPLHGGRRTGWRSTRQALWTNLDPLRALAPSPDGEPRAEYAAHVLDSPVMCVRADEGPWDVPEGLTFREWLRTGLPRPADADDLRYHMTTLFPPVRPRGHLELRMVDAQSGTDGWMVPVAVTTAVFDDPEAAETVYRAVKPLAERAGPGPAPRNPLWMAAARDGLSDPELHAAALAVFSAAREALPRMGASGEVRRAVAAFHERYVIPGSCPADDLLVVTS
>NZ_CP029196.1|WP_150162980.1|7169135_7169966_+|TIGR02452-family-protein
MSARLRAIARQTEEIVAEGHYLAPDGRTVSLTEDLAAALAGTRLHGPGPVAVTPDTDRTTTLDVTGESSLAAARRMTAADPARPVAVLNFASARNPGGGYLNGAQAQEEALCRSSALHATLLRAPAYYTHHREEKDAFYTDRVIHSPRVPVFRDDRGTLLAQPFTVGFLTSPAPNAGVIRRRTPERADQLPAALASRAERVLETAAAAGYRRLVLGAWGCGVFQNDPEQVAGTFTALLTGDGRFAAHFEEIVFAVLDRAPGAPTLAAFTRVVATTV
>NZ_CP029196.1|WP_150162981.1|7170372_7170726_-|hypothetical-protein
MTSQQATTTLWRPTGPKELDLVRELDYRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVKHDGAGFVTRFEVESEFLSRYPVQQAGGQTILELWVPAEELDDFNAHIVGEIQVVHEFR
>NZ_CP029196.1|WP_150162982.1|7171091_7171817_-|dienelactone-hydrolase-family-protein
MTTITTRTVEYPADGLTMIGHLALPAGAGPRPAVLLGPEGLGLNDFQRSLAGSLAELGYVALAFDIHGGRYFTDPQEMLARALPLLADPDRMREIGQAALDVLRAEPRTDPDRIAAVGYGTGGAIALELGRAGVDLRAIGTINALTTGRPGEAARIRCPVWAGVGSEDLIMAAAQREAFAAEMQAAGVDWRLVVYGGALHAFHHPPVDHDTVPGVGHHPLHARRAWRDIVDLLAECLPVTA
>NZ_CP029196.1|WP_150162983.1|7172035_7173451_-|flotillin-family-protein
MGIGILAGAVVGAFAVLVIVFKMMWRVAEPNEALIISGSNHKNEGLGAGMGFRIVTGRGTLVLPGVQAVRKLSLDLNETQLSVECVTHQGIPLKVRGVVIFKVGDDFVSIANAARRFLDQQKLMSERVHIVFAGHLRAIVGGLTVEDMIRDREKLTGQARSACGTEMEKLGLIVDSLQIHEIEDPTGYIKNLAAPHAAAVQRDARIAQAEANRRATEAEQQAAARMSEATRDSEILQAGYQAERDQASARARQAGPLAEAASRQEVVVQETRVAELEGHRKEQQLQAEVRKPADAAAYETRTLAAAERDARISAAEAEAKETELASAAMATATRLTGEAEAAAQHAKGLAVAEATRAKGLAEAEAIKARAAALAENQEAVVAQQLAEKWPEIVSAGASAFGNVDQMVLLNGADGMADVFAKALTMGGTGLGLARQLLTTMSPAAQERLGTGVPPATRAQSESIEITVGEGE
>NZ_CP029196.1|WP_041663218.1|7173535_7173763_-|hypothetical-protein
MDESMDSPMVGLLGRVTGTVGPGLVGEVIVRIRGGAEHFLAHPASPKERIDVGTVVTVMEHLPPRTVYVTAAYDS
>NZ_CP029196.1|WP_150162984.1|7173777_7174485_-|alpha/beta-fold-hydrolase
MRLHTTTWGSGDRTALLVHGLMADHRTWRRVGPALAERGYRVVAVDLRGHGLSPRAAGPEEYRPADHADDLVETLSGGVELAIGHSLGGLALARAAERLKPARAVYVDPAWHLGAGPDGYRPEVFVRGSTLTRAQIRSFNPDWPDEDLDTEMASVRLWDQRSAYGLVDFIGTDLWPDRAVVPSLVALADPSVLVSPEAARMLAGRGFTVRTVPGSGHTIHRDDFDGFISALDGWI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP029196_9	9.4\|3345378\|18\|NZ_CP029196\|CRT	3345378-3345395	18	NZ_CP029196.1	3838403-3838420	1	0.944
NZ_CP029196_9	9.4\|3345378\|18\|NZ_CP029196\|CRT	3345378-3345395	18	NZ_CP029196.1	6915889-6915906	1	0.944
NZ_CP029196_9	9.4\|3345378\|18\|NZ_CP029196\|CRT	3345378-3345395	18	NZ_CP029196.1	6915908-6915925	1	0.944
NZ_CP029196_14	14.1\|4670779\|17\|NZ_CP029196\|CRISPRCasFinder	4670779-4670795	17	NZ_CP029196.1	3484333-3484349	1	0.941
NZ_CP029196_3	3.4\|1564411\|36\|NZ_CP029196\|CRT	1564411-1564446	36	NZ_CP029196.1	1565278-1565313	2	0.944
NZ_CP029196_22	22.1\|6747436\|19\|NZ_CP029196\|CRISPRCasFinder	6747436-6747454	19	NZ_CP029196.1	1390986-1391004	2	0.895
NZ_CP029196_22	22.1\|6747436\|19\|NZ_CP029196\|CRISPRCasFinder	6747436-6747454	19	NZ_CP029196.1	2335352-2335370	2	0.895

1. spacer 9.4|3345378|18|NZ_CP029196|CRT matches to position: 3838403-3838420, mismatch: 1, identity: 0.944

cgtcgtcgggggactcgt	CRISPR spacer
cgtcgtcgggggagtcgt	Protospacer
************* ****

2. spacer 9.4|3345378|18|NZ_CP029196|CRT matches to position: 6915889-6915906, mismatch: 1, identity: 0.944

cgtcgtcgggggactcgt	CRISPR spacer
cgtcgtcgtgggactcgt	Protospacer
******** *********

3. spacer 9.4|3345378|18|NZ_CP029196|CRT matches to position: 6915908-6915925, mismatch: 1, identity: 0.944

cgtcgtcgggggactcgt	CRISPR spacer
cgtcgtcgtgggactcgt	Protospacer
******** *********

4. spacer 14.1|4670779|17|NZ_CP029196|CRISPRCasFinder matches to position: 3484333-3484349, mismatch: 1, identity: 0.941

ctggtgcggccggttcc	CRISPR spacer
ctggtgcggacggttcc	Protospacer
********* *******

5. spacer 3.4|1564411|36|NZ_CP029196|CRT matches to position: 1565278-1565313, mismatch: 2, identity: 0.944

tcgcggcggaagccaccaccgcggttgtcgccacca	CRISPR spacer
tcgcggcggaagccaccgccacggttgtcgccacca	Protospacer
*****************.**.***************

6. spacer 22.1|6747436|19|NZ_CP029196|CRISPRCasFinder matches to position: 1390986-1391004, mismatch: 2, identity: 0.895

agcgacccggcgagcgacc	CRISPR spacer
agcggcccggcgagcggcc	Protospacer
****.***********.**

7. spacer 22.1|6747436|19|NZ_CP029196|CRISPRCasFinder matches to position: 2335352-2335370, mismatch: 2, identity: 0.895

agcgacccggcgagcgacc	CRISPR spacer
agcgacccggcgagggtcc	Protospacer
************** * **

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019460	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed3, complete sequence	13806-13830	3	0.88
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019460	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed3, complete sequence	29282-29306	3	0.88
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	126977-127001	3	0.88
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP004394	Celeribacter indicus strain P73 plasmid pP73A, complete sequence	6932-6956	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019459	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed2, complete sequence	13924-13948	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019459	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed2, complete sequence	29524-29548	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019459	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed2, complete sequence	45124-45148	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019461	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed4, complete sequence	5820-5844	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019462	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed5, complete sequence	5809-5833	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019463	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed6, complete sequence	5426-5450	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP019464	Streptomyces autolyticus strain CGMCC0516 plasmid unnamed7, complete sequence	8575-8599	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1009045-1009069	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	497428-497452	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP029358	Azospirillum sp. CFH 70021 plasmid unnamed3	56879-56903	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	CP007644	Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence	479774-479798	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	360071-360095	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	804032-804056	4	0.84
NZ_CP029196_4	4.1\|2201706\|25\|NZ_CP029196\|CRISPRCasFinder	2201706-2201730	25	NZ_CP030828	Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence	569015-569039	4	0.84
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	NZ_CP032349	Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence	569372-569397	4	0.846
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	NZ_CP032325	Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence	454005-454030	4	0.846
NZ_CP029196_8	8.2\|3229752\|24\|NZ_CP029196\|PILER-CR	3229752-3229775	24	NC_008195	Mycobacterium phage Cooper, complete genome	63962-63985	4	0.833
NZ_CP029196_8	8.2\|3229752\|24\|NZ_CP029196\|PILER-CR	3229752-3229775	24	NC_042034	Mycobacterium phage ChrisnMich, complete sequence	63528-63551	4	0.833
NZ_CP029196_8	8.2\|3229752\|24\|NZ_CP029196\|PILER-CR	3229752-3229775	24	KF279411	Mycobacterium phage Adawi, complete genome	63460-63483	4	0.833
NZ_CP029196_2	2.3\|862385\|27\|NZ_CP029196\|CRT	862385-862411	27	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	187668-187694	5	0.815
NZ_CP029196_2	2.3\|862385\|27\|NZ_CP029196\|CRT	862385-862411	27	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	131515-131541	5	0.815
NZ_CP029196_2	2.3\|862385\|27\|NZ_CP029196\|CRT	862385-862411	27	NZ_AP019802	Thermus thermophilus strain HC11 plasmid pHC11, complete sequence	104382-104408	5	0.815
NZ_CP029196_2	2.3\|862385\|27\|NZ_CP029196\|CRT	862385-862411	27	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1159842-1159868	5	0.815
NZ_CP029196_2	2.3\|862385\|27\|NZ_CP029196\|CRT	862385-862411	27	NZ_CP041652	Streptomyces sp. RLB1-9 plasmid pRLB1-9.2, complete sequence	82605-82631	5	0.815
NZ_CP029196_2	2.3\|862385\|27\|NZ_CP029196\|CRT	862385-862411	27	NC_047992	Microbacterium phage Zeta1847, complete genome	40035-40061	5	0.815
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	NZ_CP044425	Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence	55896-55921	5	0.808
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	432779-432804	5	0.808
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	NZ_CP007575	Streptomyces albulus strain NK660 plasmid pNKL, complete sequence	8869-8894	5	0.808
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	MT114163	Mycobacterium phage Settecandela, complete genome	44028-44053	5	0.808
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	MK937592	Mycobacterium phage Phrappuccino, complete genome	44028-44053	5	0.808
NZ_CP029196_7	7.1\|3010202\|26\|NZ_CP029196\|CRISPRCasFinder	3010202-3010227	26	NZ_CP022369	Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence	12543-12568	5	0.808
NZ_CP029196_2	2.3\|862385\|27\|NZ_CP029196\|CRT	862385-862411	27	NZ_CP013069	Pannonibacter phragmitetus strain 31801 plasmid p.p-1, complete sequence	18211-18237	6	0.778
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	NZ_AP018921	Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence	233508-233545	7	0.816
NZ_CP029196_9	9.3\|3345330\|30\|NZ_CP029196\|CRT	3345330-3345359	30	NC_023282	Streptomyces sp. FR1 plasmid pFRL2, complete sequence	41652-41681	7	0.767
NZ_CP029196_17	17.1\|5435645\|29\|NZ_CP029196\|CRISPRCasFinder	5435645-5435673	29	NZ_CP025962	Rhodococcus qingshengii strain djl-6-2 plasmid pDJL3, complete sequence	486-514	7	0.759
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	NC_010311	Streptomyces sp. HK1 plasmid pSHK1, complete sequence	184827-184864	9	0.763
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	NZ_CP030772	Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence	713045-713082	9	0.763
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	CP000663	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence	97641-97678	9	0.763
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	NZ_CP031752	Rhodobacter sphaeroides strain EBL0706 plasmid p.A, complete sequence	43743-43780	9	0.763
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	NZ_CP046568	Dietzia sp. DQ12-45-1b plasmid pI, complete sequence	55754-55791	9	0.763
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	720610-720647	9	0.763
NZ_CP029196_21	21.1\|6080685\|35\|NZ_CP029196\|CRISPRCasFinder	6080685-6080719	35	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	52215-52249	9	0.743
NZ_CP029196_23	23.1\|6960748\|35\|NZ_CP029196\|CRISPRCasFinder	6960748-6960782	35	NC_017791	Deinococcus gobiensis I-0 plasmid P2, complete sequence	373098-373132	9	0.743
NZ_CP029196_7	7.2\|3010256\|38\|NZ_CP029196\|CRISPRCasFinder	3010256-3010293	38	NZ_CP044425	Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence	131416-131453	11	0.711

1. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019460 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed3, complete sequence) position: , mismatch: 3, identity: 0.88

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaagcgacccggcggcg	Protospacer
 * *********************.

2. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019460 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed3, complete sequence) position: , mismatch: 3, identity: 0.88

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaagcgacccggcggcg	Protospacer
 * *********************.

3. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 3, identity: 0.88

cccggccggaagcgacccggcggca	CRISPR spacer
cgcggccggcagcgccccggcggca	Protospacer
* ******* **** **********

4. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP004394 (Celeribacter indicus strain P73 plasmid pP73A, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
cccggccggaatcgacccggcgctt	Protospacer
*********** ********** .

5. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019459 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaatcgacccggcggcg	Protospacer
 * ******** ************.

6. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019459 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaatcgacccggcggcg	Protospacer
 * ******** ************.

7. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019459 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed2, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaatcgacccggcggcg	Protospacer
 * ******** ************.

8. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019461 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed4, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaatcgacccggcggcg	Protospacer
 * ******** ************.

9. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019462 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed5, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaatcgacccggcggcg	Protospacer
 * ******** ************.

10. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019463 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed6, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaatcgacccggcggcg	Protospacer
 * ******** ************.

11. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP019464 (Streptomyces autolyticus strain CGMCC0516 plasmid unnamed7, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gcgggccggaatcgacccggcggcg	Protospacer
 * ******** ************.

12. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
cccggccgggggcgacccggcgggc	Protospacer
*********..************

13. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
cgcacccggaagcgacccggcggcc	Protospacer
* *. *******************

14. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP029358 (Azospirillum sp. CFH 70021 plasmid unnamed3) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
gccggacggaagcgagccggcggct	Protospacer
 **** ********* ********

15. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to CP007644 (Rhizobium etli bv. phaseoli str. IE4803 plasmid pRetIE4803c, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
agcggcaggaagcgtcccggcggca	Protospacer
  **** ******* **********

16. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
cccggccggaagcgtgccggcggac	Protospacer
**************  *******

17. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
cccggccgggggcgacccggcgggc	Protospacer
*********..************

18. spacer 4.1|2201706|25|NZ_CP029196|CRISPRCasFinder matches to NZ_CP030828 (Neorhizobium sp. NCHU2750 plasmid pNCHU2750a, complete sequence) position: , mismatch: 4, identity: 0.84

cccggccggaagcgacccggcggca	CRISPR spacer
tccggccggtagcgatccggcggcc	Protospacer
.******** *****.********

19. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to NZ_CP032349 (Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence) position: , mismatch: 4, identity: 0.846

tcccggccgtcaagccggtcccggct	CRISPR spacer
ccccggccgccaagccggtgccggcc	Protospacer
.********.********* *****.

20. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to NZ_CP032325 (Azospirillum brasilense strain MTCC4035 plasmid p4, complete sequence) position: , mismatch: 4, identity: 0.846

tcccggccgtcaagccggtcccggct	CRISPR spacer
ccccggccgccaagccggtgccggcg	Protospacer
.********.********* *****

21. spacer 8.2|3229752|24|NZ_CP029196|PILER-CR matches to NC_008195 (Mycobacterium phage Cooper, complete genome) position: , mismatch: 4, identity: 0.833

cagcggtggcacggcctccacgga	CRISPR spacer
tcgcggtggcagggcctccacggt	Protospacer
. ********* ***********

22. spacer 8.2|3229752|24|NZ_CP029196|PILER-CR matches to NC_042034 (Mycobacterium phage ChrisnMich, complete sequence) position: , mismatch: 4, identity: 0.833

cagcggtggcacggcctccacgga	CRISPR spacer
tcgcggtggcagggcctccacggt	Protospacer
. ********* ***********

23. spacer 8.2|3229752|24|NZ_CP029196|PILER-CR matches to KF279411 (Mycobacterium phage Adawi, complete genome) position: , mismatch: 4, identity: 0.833

cagcggtggcacggcctccacgga	CRISPR spacer
tcgcggtggcagggcctccacggt	Protospacer
. ********* ***********

24. spacer 2.3|862385|27|NZ_CP029196|CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 5, identity: 0.815

gctcacccccgcctcccccgggcccag	CRISPR spacer
cacctcccccgcctcccccgggcccac	Protospacer
  .* *********************

25. spacer 2.3|862385|27|NZ_CP029196|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 5, identity: 0.815

gctcacccccgcctcccccgggcccag	CRISPR spacer
cacctcccccgcctcccccgggcccac	Protospacer
  .* *********************

26. spacer 2.3|862385|27|NZ_CP029196|CRT matches to NZ_AP019802 (Thermus thermophilus strain HC11 plasmid pHC11, complete sequence) position: , mismatch: 5, identity: 0.815

gctcacccccgcctcccccgggcccag	CRISPR spacer
cacctcccccgcctcccccgggcccac	Protospacer
  .* *********************

27. spacer 2.3|862385|27|NZ_CP029196|CRT matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 5, identity: 0.815

gctcacccccgcctcccccgggcccag	CRISPR spacer
cggcacccccgcctcccccgcgcccgg	Protospacer
   ***************** ****.*

28. spacer 2.3|862385|27|NZ_CP029196|CRT matches to NZ_CP041652 (Streptomyces sp. RLB1-9 plasmid pRLB1-9.2, complete sequence) position: , mismatch: 5, identity: 0.815

gctcacccccgcctcccccgggcccag	CRISPR spacer
gctcacccccgcctccgcggggcggac	Protospacer
**************** * ****  *

29. spacer 2.3|862385|27|NZ_CP029196|CRT matches to NC_047992 (Microbacterium phage Zeta1847, complete genome) position: , mismatch: 5, identity: 0.815

gctcacccccgcctcccccgggcccag	CRISPR spacer
catcgcccccgcctcccccgcgcccgg	Protospacer
  **.*************** ****.*

30. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to NZ_CP044425 (Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence) position: , mismatch: 5, identity: 0.808

tcccggccgtcaagccggtcccggct	CRISPR spacer
ggtcggccgtcaagccggtccaggcg	Protospacer
  .****************** ***

31. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 5, identity: 0.808

tcccggccgtcaagccggtcccggct	CRISPR spacer
acgcggccggcaagccggtcccgggc	Protospacer
 * ****** ************** .

32. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to NZ_CP007575 (Streptomyces albulus strain NK660 plasmid pNKL, complete sequence) position: , mismatch: 5, identity: 0.808

tcccggccgtcaagccggtcccggct	CRISPR spacer
gcccgaccgacaagccggtcccgggc	Protospacer
 ****.*** ************** .

33. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to MT114163 (Mycobacterium phage Settecandela, complete genome) position: , mismatch: 5, identity: 0.808

tcccggccgtcaagccggtcccggct	CRISPR spacer
caccgccggtcaagccggtcccggcg	Protospacer
. *** * *****************

34. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to MK937592 (Mycobacterium phage Phrappuccino, complete genome) position: , mismatch: 5, identity: 0.808

tcccggccgtcaagccggtcccggct	CRISPR spacer
caccgccggtcaagccggtcccggcg	Protospacer
. *** * *****************

35. spacer 7.1|3010202|26|NZ_CP029196|CRISPRCasFinder matches to NZ_CP022369 (Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence) position: , mismatch: 5, identity: 0.808

tcccggccgtcaagccggtcccggct	CRISPR spacer
cgccggccgccaagccggtgccggcg	Protospacer
. *******.********* *****

36. spacer 2.3|862385|27|NZ_CP029196|CRT matches to NZ_CP013069 (Pannonibacter phragmitetus strain 31801 plasmid p.p-1, complete sequence) position: , mismatch: 6, identity: 0.778

gctcacccccgcctcccccgggcccag	CRISPR spacer
gctcaccctcgcctcccccggacttga	Protospacer
********.************.*....

37. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to NZ_AP018921 (Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence) position: , mismatch: 7, identity: 0.816

ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
ccccggccccggcccccgccccggcccccgccctggtc	Protospacer
*************.******** ********* * .

38. spacer 9.3|3345330|30|NZ_CP029196|CRT matches to NC_023282 (Streptomyces sp. FR1 plasmid pFRL2, complete sequence) position: , mismatch: 7, identity: 0.767

ggtggtcggcgggggttcctccgtcgtcgg	CRISPR spacer
ccggatcggcgtgggttcctccgtcgccgt	Protospacer
   *.****** **************.**

39. spacer 17.1|5435645|29|NZ_CP029196|CRISPRCasFinder matches to NZ_CP025962 (Rhodococcus qingshengii strain djl-6-2 plasmid pDJL3, complete sequence) position: , mismatch: 7, identity: 0.759

cgccagtcgtaggcgacttcgaggcagtt	CRISPR spacer
acccagtctttggcgacttcgaggctttc	Protospacer
  ****** * **************  *.

40. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to NC_010311 (Streptomyces sp. HK1 plasmid pSHK1, complete sequence) position: , mismatch: 9, identity: 0.763

------ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
agaccgcccccgcccccgcccccgcccccgcccccgcc------	Protospacer
      **** ***** **.******************

41. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to NZ_CP030772 (Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence) position: , mismatch: 9, identity: 0.763

------ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
gccgcgcccccgcccccgcccccgcccccgcccccgcc------	Protospacer
      **** ***** **.******************

42. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to CP000663 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA02, complete sequence) position: , mismatch: 9, identity: 0.763

ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
ccccggcccctgctccggcccccgccccggtgggggcg	Protospacer
********** ***** *********** *. *  . *

43. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to NZ_CP031752 (Rhodobacter sphaeroides strain EBL0706 plasmid p.A, complete sequence) position: , mismatch: 9, identity: 0.763

ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
ccccggcccctgctccggcccccgccccggtgggggcg	Protospacer
********** ***** *********** *. *  . *

44. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to NZ_CP046568 (Dietzia sp. DQ12-45-1b plasmid pI, complete sequence) position: , mismatch: 9, identity: 0.763

ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
ccccggccccggctcccgcgccagccccggtcccggcg	Protospacer
******************* ** ***** *.* . . *

45. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 9, identity: 0.763

ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
gtcccaccacggctcccgcctccgcccccgccgcgaaa	Protospacer
 .** .** ***********.************. **.

46. spacer 21.1|6080685|35|NZ_CP029196|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.743

ctaccgctgctgtagctggacttgtgccaggagag	CRISPR spacer
tgtgcgctgctgtagctggacttgaaccaaccgag	Protospacer
.   ******************** .***.  ***

47. spacer 23.1|6960748|35|NZ_CP029196|CRISPRCasFinder matches to NC_017791 (Deinococcus gobiensis I-0 plasmid P2, complete sequence) position: , mismatch: 9, identity: 0.743

tacgcctgacgaaccgcctcccggccgggcctggc	CRISPR spacer
tacgcctgacggaccgcctcgcggcgcgcaccctc	Protospacer
***********.******** ****  *  *.  *

48. spacer 7.2|3010256|38|NZ_CP029196|CRISPRCasFinder matches to NZ_CP044425 (Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence) position: , mismatch: 11, identity: 0.711

------ccccggccccggctcccgcccccgcccccgccgtcaag	CRISPR spacer
ctccggcccccgctccggcccccgcccccgctccggcc------	Protospacer
      **** **.*****.***********.** ***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1528700 : 1535816

Bacillus_virus(14.29%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_150159911.1\|1528700_1529393_+	nucleotidyltransferase	G3M9V9	Bacillus_virus	4.3e-16	28.3
WP_150159912.1\|1529483_1530257_-	nucleotidyltransferase domain-containing protein	K4K696	Caulobacter_phage	1.4e-07	37.1
WP_150159913.1\|1530260_1531292_-	ADP-ribosylglycohydrolase family protein	A0A2D0ZND4	Rhodococcus_phage	1.2e-25	31.1
WP_150159914.1\|1531288_1532056_-	NUDIX domain-containing protein	A0A0E3JJF3	Streptomyces_phage	3.7e-21	46.7
WP_150159915.1\|1532052_1533132_-	AAA family ATPase	A0A2K8HHU5	Bacteriophage	4.0e-29	31.1
WP_150159916.1\|1533128_1533782_-	nicotinamide mononucleotide transporter	A0A0F6YPU8	Sinorhizobium_phage	3.8e-14	31.2
WP_150159917.1\|1533930_1535202_-	pseudouridine synthase	NA	NA	NA	NA
WP_015032608.1\|1535201_1535816_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.4e-09	29.4

DBSCAN-SWA_2

4569711 : 4588017

Streptomyces_phage(72.73%)

tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041662771.1\|4569711_4573194_+	DNA-directed RNA polymerase subunit beta	G8DH04	Emiliania_huxleyi_virus	2.0e-29	22.2
WP_150161571.1\|4573301_4577201_+	DNA-directed RNA polymerase subunit beta'	A0A2I7QNZ7	Vibrio_phage	6.5e-53	27.4
WP_015035543.1\|4577266_4577530_-	hypothetical protein	A0A1J0MCA5	Streptomyces_phage	2.8e-29	78.2
WP_015035544.1\|4577516_4577762_-	hypothetical protein	A0A142K647	Streptomyces_phage	1.1e-19	69.3
WP_150161572.1\|4577785_4578697_-	N-acetylmuramoyl-L-alanine amidase	A0A2P1N078	Streptomyces_phage	4.3e-101	59.5
WP_150161573.1\|4578774_4579185_-	ATP-binding protein	NA	NA	NA	NA
WP_015035547.1\|4579225_4579795_-	hypothetical protein	NA	NA	NA	NA
WP_015035548.1\|4579794_4580925_-	hypothetical protein	A0A2H5BLE2	Streptomyces_phage	2.7e-84	45.3
WP_150161574.1\|4580936_4582082_-	hypothetical protein	A0A1J0MCI7	Streptomyces_phage	2.2e-57	38.8
WP_150161575.1\|4582113_4583307_-	hypothetical protein	A0A1V0E646	Streptomyces_phage	1.4e-43	44.1
WP_150161576.1\|4583344_4584538_-	hypothetical protein	A0A1J0MCI7	Streptomyces_phage	1.9e-43	50.7
WP_015035552.1\|4584587_4585520_-	hypothetical protein	A0A1J0MCE5	Streptomyces_phage	7.7e-53	43.1
WP_150161577.1\|4585567_4586815_-	tape-measure protein	NA	NA	NA	NA
WP_015035554.1\|4586811_4588017_-\|tail	phage tail protein	Q8SBP1	Clostridium_phage	1.1e-08	45.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP029196

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection