CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP029197	Streptomyces venezuelae ATCC 10712 chromosome, complete genome	23 crisprs	csa3,WYL,DEDDh,cas4,cas3,DinG,RT	3	7	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP029197_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_1

792049-792156

Orphan

Consensus_repeat	Method
CGCGCCGGGGATCAGACCGCCCGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_1

>merge|NZ_CP029197|1|792049-792156|CRISPRCasFinder
CGCGCCGGTGACCGGACCGCCCGGCCGGTGATCGGACGCCGCGCGCCGGGGATCAGACCGCCCGGCCGGTGACCGGACGCCGCGCGCCGGGGATCAGACCGCGCGGCC

>NZ_CP029197|1|1|792049-792156|CRISPRCasFinder
CGCGCCGGTGACCGGACCGCCCGGCC	GGTGATCGGACGCCGCGCGCCGGGGATCAGACCGCCCGGCCGGTGACCGGACGCCG
CGCGCCGGGGATCAGACCGCGCGGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_041662033.1\|786850_788743_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP029197.1\|WP_071891119.1\|783549_784005_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015031894.1\|803506_803947_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176854
NZ_CP029197.1\|WP_051025829.1\|792180_792753_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015031883.1\|790206_791889_-\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|223885
NZ_CP029197.1\|WP_015031879.1\|785401_786769_+\|MHS-family-MFS-transporter	unknown	unknown	gnl\|CDD\|340927
NZ_CP029197.1\|WP_015031890.1\|797684_800090_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|163057
NZ_CP029197.1\|WP_015031874.1\|782224_782641_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041662026.1\|782929_783334_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP029197.1\|WP_015031889.1\|796883_797492_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015031882.1\|789655_790138_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|240032
NZ_CP029197.1\|WP_015031873.1\|781848_782073_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015031885.1\|792815_793610_-\|glutamate-racemase	unknown	unknown	gnl\|CDD\|234851
NZ_CP029197.1\|WP_015031887.1\|795364_795880_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235124
NZ_CP029197.1\|WP_015031881.1\|788790_789600_-\|3-hydroxybutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|211705
NZ_CP029197.1\|WP_015031886.1\|793668_794847_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|213815
NZ_CP029197.1\|WP_041662028.1\|784164_784707_-\|SMI1/KNR4-family-protein	unknown	unknown	gnl\|CDD\|214864
NZ_CP029197.1\|WP_015031895.1\|804160_804661_+\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176863
NZ_CP029197.1\|WP_015031888.1\|795935_796760_+\|MOSC-domain-containing-protein	unknown	unknown	gnl\|CDD\|225758
NZ_CP029197.1\|WP_015031893.1\|802682_803510_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_041662033.1\|786850_788743_-\|GAF-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	6.6208e-15
NZ_CP029197.1\|WP_015031882.1\|789655_790138_-\|NUDIX-domain-containing-protein	gnl\|CDD\|240032	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	7.67957e-54
NZ_CP029197.1\|WP_015031894.1\|803506_803947_+\|SRPBCC-family-protein	gnl\|CDD\|176854	cd07812, SRPBCC, START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket; they bind diverse ligands. Included in this superfamily are the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), as well as the SRPBCC domains of phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of this superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	5.34756e-07
NZ_CP029197.1\|WP_015031883.1\|790206_791889_-\|apolipoprotein-N-acyltransferase	gnl\|CDD\|223885	COG0815, Lnt, Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane].	1.5281e-94
NZ_CP029197.1\|WP_015031879.1\|785401_786769_+\|MHS-family-MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0
NZ_CP029197.1\|WP_015031890.1\|797684_800090_+\|AAA-family-ATPase	gnl\|CDD\|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	1.1378e-90
NZ_CP029197.1\|WP_041662026.1\|782929_783334_+\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	9.13802e-09
NZ_CP029197.1\|WP_015031885.1\|792815_793610_-\|glutamate-racemase	gnl\|CDD\|234851	PRK00865, PRK00865, glutamate racemase; Provisional.	1.25159e-46
NZ_CP029197.1\|WP_015031887.1\|795364_795880_+\|hypothetical-protein	gnl\|CDD\|235124	PRK03427, PRK03427, cell division protein ZipA; Provisional.	6.43646e-06
NZ_CP029197.1\|WP_015031881.1\|788790_789600_-\|3-hydroxybutyrate-dehydrogenase	gnl\|CDD\|211705	TIGR01963, D-beta-hydroxybutyrate_dehydrogenase, 3-hydroxybutyrate dehydrogenase. This model represents a subfamily of the short chain dehydrogenases. Characterized members so far as 3-hydroxybutyrate dehydrogenases and are found in species that accumulate ester polmers called polyhydroxyalkanoic acids (PHAs) under certain conditions. Several members of the family are from species not known to accumulate PHAs, including Oceanobacillus iheyensis and Bacillus subtilis. However, polymer formation is not required for there be a role for 3-hydroxybutyrate dehydrogenase; it may be members of this family have the same function in those species.	3.2225e-121
NZ_CP029197.1\|WP_015031886.1\|793668_794847_+\|glycosyltransferase	gnl\|CDD\|213815	TIGR03469, HpnB, hopene-associated glycosyltransferase HpnB. This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The genes of this family are often found in the same genetic locus with squalene-hopene cyclase genes, and are never associated with genes for the metabolism of phytoene. Indeed, the members of this family appear to never be found in a genome lacking squalene-hopene cyclase (SHC), although not all genomes encoding SHC have this glycosyl transferase. In the organism Zymomonas mobilis the linkage of this gene to hopanoid biosynthesis has been noted and the gene named HpnB. Hopanoids are known to feature polar glycosyl head groups in many organisms.	2.73433e-158
NZ_CP029197.1\|WP_041662028.1\|784164_784707_-\|SMI1/KNR4-family-protein	gnl\|CDD\|214864	smart00860, SMI1_KNR4, SMI1 / KNR4 family. Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.	1.30311e-05
NZ_CP029197.1\|WP_015031895.1\|804160_804661_+\|polyketide-cyclase	gnl\|CDD\|176863	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins. The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.	6.99128e-14
NZ_CP029197.1\|WP_015031888.1\|795935_796760_+\|MOSC-domain-containing-protein	gnl\|CDD\|225758	COG3217, COG3217, Uncharacterized Fe-S protein [General function prediction only].	3.47094e-66
NZ_CP029197.1\|WP_015031893.1\|802682_803510_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.66968e-75

>NZ_CP029197.1|WP_015031883.1|790206_791889_-|apolipoprotein-N-acyltransferase
MSATITPVDASGPDTAPPPGLRLRRFVRPGAALLSGFLLYLSFPPRPLWWLALPAFALLGWTLRGRRPRAGFGLGYLAGLGFLLPLLVWTGEEVGAVPWLALAAVEALFVAAAGLGIAAVSRLPWWPVFAAGVWILAEAARARVPFGGFPWGKIAFGQADGIFLPLAAVGGTPVLGFAVALCGFGLYETYRQIQLRRAARTSPSEDTVDTDTDTDTDAGTVAVGTRPRPHPRGPLVAAALAVLVPVTGALAALPLVDDAAEDGTATVAAVQGNVPRLGLDFNSQRRAVLDNHAARTRELAEDVKAGREPQPDFVLWPENSSDIDPYANADAADVIDGAVRAIGVPTVIGAVVAPETGKLRNTLIEWDPRKGPVATYDKRHVQPFGEYIPMRSFVRLFNSNVDRVSRDFGAGTKVGVFDLAGTKVGLATCYEAAFDWAVRDTVTHGAQLITVPSNNATFGRSEMTYQQLAMSRVRAVEHSRSVVVPVTSGVSAVIRPDGEIVAETKMFTPDVLVEKVPLRSSLTPATRMGTLPEALLVALAAAGLGWSALRSVRARRARTE
>NZ_CP029197.1|WP_015031882.1|789655_790138_-|NUDIX-domain-containing-protein
MATPDFIRALRETAGHQLLFLPGVSAVVLDDRGRVLLGRRADNGLWSVIGGIVEPGEQPADCAVREVYEETAVRCEVERVVLVETLRKPVVYPNGDRCQFMDVSFRCRAVGGEARVNDDESTEVGWFDVDDLPEMKRFAYLRIEKALADEPTWFRTTATS
>NZ_CP029197.1|WP_015031881.1|788790_789600_-|3-hydroxybutyrate-dehydrogenase
MSALDLVSAAPRPSAVVLDLTGRTALVTGAAGGIGRACALRLAAAGARVRAVDRAAEGLETLTAQAEGLPGSLEPRLLDLTDLDAAEAAAAGADILVNNAGIQLVRPIEEFPPDVFHTVLTVMLEAPFRLIRGALPHMYAQGWGRIVNLSSVHGLRASAFKSAYVAAKHGLEGLSKTAALEGAPHGVTSNCVNPGYVRTPLVERQIADQAAAHGIPPERVLSEVLLKDSALKRLIEPDEVAEAVLYLCTSQASFITGTSLTLDGGWTAH
>NZ_CP029197.1|WP_041662033.1|786850_788743_-|GAF-domain-containing-protein
MSHEHVSYLELLARGAATEAYDRPVLLARASGAGPEALAELEEAKQLALRVRAELEGRRRREAELSALFATAHDLAGLRDLDAVLRAIVQRARSLLGTECAYLSLNDPAAGDTYMRVTEGSVSARFQQLRLGMGEGLGGLVAQTARPYVTDDYFDDARFQHTRTIDTAVRDEGLVAILGVPLTLGSQVIGVLFAADRRARVFEREQVALLGSFAAHAAVAIDTANLLAETRSALAELERANDIIREHSGVIERASEVHDRLSELVLHGGGVHDVARAVSEVLGGTVEFTEEGAGTSRGTGGHAVREGDDWVAAVSAGGEALGALVLHGQPDLDPVDQRTLERAALVTSLLLLARRSAGEAEQRVRGELLDDLLDAPDRDRRLLRERAARLRTDSEAPHVVLAARIDRAGGAADPDAGGRESADRQRLWSAASHLAATRHGLASARDGGTVLLLPLGPGESAADLARQTARGLGGTLREPVTVGASAPVRAPLDHPDQVAVAYQEARRCLDALRLLHRSGQGAAAEDLGFLGLLLADGRDIDGFVDRTVGQVVAYDRRRGTDLVRTLDAYFASGMSPARTKDELHVHVNTVAQRLERVGRLLGPDWQSPARALEIQLALRLHALSDAVTRG
>NZ_CP029197.1|WP_015031879.1|785401_786769_+|MHS-family-MFS-transporter
MAAATPSPTPPGSLKRIVAASLIGTTIEWYDFFLYGSAAALVFNKLFFPESDPLVGTLLSFLTYAVGFAARPLGALVFGHYGDRLGRKKLLVLSLLLMGGATFAIGLLPTHATVGSAAPVLLTVLRLVQGFALGGEWGGAVLLVSEHGDAKRRGFWASWPQTGAPAGQLLATGVLSALTALLSDASFASWGWRVPFLLSGVLVIVGLWIRLSVDESPVFKAALAAAEERKAAGAQVEKMPLVAVLRHHWRDVLVAMGARMAENISYYVITAFILVYATTEVGLSKQTALNAVLIGSAVHFAVIPLWGALSDRLGRRPVYLIGAVGVGAWMFPFFLLIDRGTFGSLLLAVTVGLVLHGAMYAPQAAFFSEMFATRMRYSGASIGAQFSSVAAGAPAPLIATALLADYGDSTPIALYVIAAALLTVVAIACARETRDSDLGDVEERTSPDAKVGAGA
>NZ_CP029197.1|WP_041662028.1|784164_784707_-|SMI1/KNR4-family-protein
MTDTRDQRPAEATLDFLRSAFPPEWREQALGHEAVADWEQENGVVLPEPYRTFIAEISNGSSLGPAGDGGLQPLGWLPNAWPDLGPRQPGEPFPLAAAWPWEDDESVDPGDPRIDAAFNKGSIVLGSEDGQAFWLLLTAGPRRGEVWMIADVGAVPAPGDKAWGFEEWVQRWHTGNDWWN
>NZ_CP029197.1|WP_071891119.1|783549_784005_+|hypothetical-protein
MIAAAIDMGVGVMNGGRSTRWSLDEKNYSQGWWVPLGVVVVAAATWGSLGFVEGGCQPGPRGGCVAADGYELRSWVVYLASMPTLFVVVTGLTADRWPPVLGIAAGGAACGLYTLTQGHTIPHLIMAAALFALSITAPTLAWRRRRAARAE
>NZ_CP029197.1|WP_041662026.1|782929_783334_+|STAS-domain-containing-protein
MVPNRPQDDGPRARLHLIDGAPAWRPHVGDALVRYAPVGCPATAALVLTGAFDADTTPSLREALDAVRNPQIELVLLDLAAVRFGDAAFVRELTDTQCRPERHVLIGPLPGPIARLLDITGTRQAFDVALDDAA
>NZ_CP029197.1|WP_015031874.1|782224_782641_+|hypothetical-protein
MGMRMVIEELADEAERQVRDQVWILGAADLAAATKAADNLHDAISSRLVQDELPLVQRLAHLREALAVLAVALAHVHGRMAWFLGAATTALTPILNWRALPPDDGPTFGAVQPTLQQYEDAEDAVRRLQKALAAITTA
>NZ_CP029197.1|WP_015031873.1|781848_782073_+|hypothetical-protein
MGSTPITVHRPSPSGGRRVTAHRHGHDEILGVAYSDRDLAVFLDRAGVPDPETAIDDPAWVEWRGGLAHQWDAA
>NZ_CP029197.1|WP_051025829.1|792180_792753_-|hypothetical-protein
MRERARNLRTDERMPAVWTGRATNRFQWVAAVAGAACMALGITIAVESAWTSGILALLMAVIGCVAAGLLVLFGTLAFVHVAVRVDDSAMEVRCGHIGVPRRRILLAQVVGADFEPSVTPRHWGGWGYRWRPEKGTAVVVRRGEGLILRLGDGRTFTVTVDDAESAVRVIRDHLRDITPPTPPAPTGRAV
>NZ_CP029197.1|WP_015031885.1|792815_793610_-|glutamate-racemase
MKIALMDSGIGLLPAAAAVRRLRPDADLLLSNDPDGMPWGPRTPEDLTGRALAVALAAAEHRPQALIVACNTATVHALPAIRAALEPDIAVIGTVPAIKPAAAGGGKVAIWATPATTGSAYQRGLIRDFADGAEVTEVPCPGLADAVEHADPEAVDRAVAAAAALTPRDVRTVVLGCTHYELVEERILAALDARGRAGLPPIVFHGSADAVAAQALRRVGAEPAPAAAPTGTLSVLLSGRPGALPATALGYAEGRLLGAAAPAH
>NZ_CP029197.1|WP_015031886.1|793668_794847_+|glycosyltransferase
MSTLAWFALGSLAVWAWLLLGQGFFWRTDQRLPPVPRGGPDRWPRVVVVVPARDEAGVLPLSLPSLLAQDYPGVAEVILVDDGSTDGTGKLAVGLAGRYGGLPLTVVSPGEPEAGWTGKLWALRHGMALARAREPEFLLLTDADIAHEPDSLRLLVAAATANGLDLVSQMARLRVASFWERLVVPAFVYFFAQLYPFRWINRRRPLATAAAGGCVLLRTETAVAAAVPEVIRQAVIDDVSLARAVRRAGGRIWLGLAERVDSVRPYPGLGELWRMVARSAYAQLRHSPLLLAGTVAGLAVVYLVPPAALVAGVAGGDAVAAWAGGVAWAVMAGTYGPMLRYYRQPLWLAPLLPFTAFLYLLMTVDSAVRHHRGRGAAWKGRTYARPEATSER
>NZ_CP029197.1|WP_015031887.1|795364_795880_+|hypothetical-protein
MTSPRSTYGGGYHTAPSFPDTPIYDSLVAERGTPQIAPIRVPAAYDTGSSFQPTGSSFPSSGSYLPALPAALPALPAAPTPQPSYGNGYGYPQPTPQMAPVPLQHAPAPYIPQQQAAPRGYQGGQYPQPPRPAPAGYEAMRPASPRPAPAPVPAPTPYDDPYNRPYQGGGY
>NZ_CP029197.1|WP_015031888.1|795935_796760_+|MOSC-domain-containing-protein
MPTPVLRSVHVHPVKAMRALARTEAEVQPWGLAGDRRWAVVDTAGKVVTQRRHPRMALATAEPLPDGGITLSAAGHAPLAVEVPHPSETVAVEIFEKHVEAVPATDAAAAWLSAYLEGEFRLVHMDAPEHRRPIDPDYALPGETVSFADGYPLLVAATSSLDALNSLIAQGDHAHEGPLPMNRFRPNLVIEGTSPWAEDGWTRLAVGEVTFRVARPCGRCVVTTTDQSSAERGKEPLRTLARHRKSDGRVIFGQNLVPEHTGTVRVGDEVKILD
>NZ_CP029197.1|WP_015031889.1|796883_797492_+|hypothetical-protein
MRAAIGLWRWRHNPLRRTTDLVEAWVAFAALALLCLVVPLTGWAAGASAHGSLQRAVRTQQEQRVPTSARVVRAADRPVGGGRTAEATGEERLRRSVVARWTAPDGTVRTATVTTARRTSAPGTTFPLWTDRHGNPVAPPMHPDTARAHAIVAGLTAALLAGLMVETVRRLAVRRLVLLRYARLDRAWAAVGPDWGRTGTGS
>NZ_CP029197.1|WP_015031890.1|797684_800090_+|AAA-family-ATPase
MAQGTVQVTHTGTSRWRRRTGEYPSLAAALEAAGDGDVLTVAPGTYRENLVVRRAVTLRGPEGAIGSVRIAPPDGVPLTLRASVTIQDLHIEGQDVAAPALLVEDGTPELLDLRIMTRSAAGIEVRGAARPTVRRCTVDNPAGVGIAVVDGAGGVFEECEVVSAGQAGISVRGGAHPRLDRCRVHHASGAGIAVTGEGSALEGVGCEVYEIKGAGLQLAARATAHLTDSSVHRTSGDGITLDTDAVLTLDDCDIHDVPENAVDLRSRSVLTLTRSTVRRFGRNGLSVWDPGTRVDANQCEIHDSTGDYPAVWVSDGATAVLDACRVHDVPDALFVLDRGSRVDVVDSDLSQVRNTAVSVSDGATAQLDDCRIREASTGAWFRDHGSGGTLGGCTIDSVQTGVIVTKGADPTIDRCTVTSPAEAGFYVSAEGRGSFTGCRVTGSGGYGFHVTDGCRTTLRKCRTERCARGGYEFPEEGASAEDCTSDESAVRSSVPDGGTVLTATRSAGLLGTVPVPRPAAPVPAVVAPPADARSSQDVLGELDALVGLESVKLEVRTLTNMIEVGRRRQEAGLKAASVRRHLVFTGNPGTGKTTVARLYGEILASLGVLERGHLVEVSRVDLVGEHIGSTAIRTQEAFDRARGGVLFVDEAYALSPEDSGRDFGREAIDTLVKLMEDHRDAVVVIVAGYTAEMERFLTVNPGVASRFSRTITFGDYHPEELLRIVGQQADEHEYRLAPGTAEALLAYFTKLPKGPAFGNGRTARQTFESMVERHAGRVAALAEASTDDLTLLYPEDLPELP
>NZ_CP029197.1|WP_015031893.1|802682_803510_+|DeoR/GlpR-transcriptional-regulator
MTDNQNLLAEQRRALILDEVRRRGGVRVNELTRRLSVSDMTIRRDLDALARQGMLAKVHGGAVPVVEASTHEPGFEAKSVLEPSAKDEIARAAAALVAPGSAIALSGGTTTYALARHLLDVPELTVVTNSVRVADVFHEAQLAGSGGESRRGAATVVLTGGMRTPSDALVGPVADRAVRSLHFDLLFLGVHGVSVEAGLSTPNLAEAETNGCLMRSARRVVVVADHTKWGTVGLSSFAALDEVDTWVTDGAMSGEVRAEILEHVPGLTVAGEEQA
>NZ_CP029197.1|WP_015031894.1|803506_803947_+|SRPBCC-family-protein
MSLFRVERAVPLAPEEVWRRLTDWPAHGRQVPLTRTRVLTPGPNGAGVRFTARTGIGRLSFDDPMEVVRWEPPAAGRPGVCRLEKSGRVVRGWAVVEVTSAPGGGSRVVWTEELSLRGLPRAFDPVLGAAGRFLFGRAVDGLLREG
>NZ_CP029197.1|WP_015031895.1|804160_804661_+|polyketide-cyclase
MARRLRPVELDFTLSAPVRLVFTATLAAPPPAVYRSLAVEVGSMPAWFTAVRSAVPSGDGAGRTIRLRGGIAFEETILASEPDVRYAYRVDSTNAPGLTALAEEWALSPTGKGTRLRWTMAADGATPFRLALRLAGPGVGLSFRDAARRLDRRLTPARPRSPGTVR

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Crispr_ID: NZ_CP029197_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_2

861363-861431

Orphan

Consensus_repeat	Method
CCGACGGACGGCGGCTCGCGCCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_2

>merge|NZ_CP029197|2|861363-861431|CRISPRCasFinder
CCGACGGACGGCGGCTCGCGCCCGCTCCACCCGGGGGCGGGTGCCCGGCGGGCGGCGGCTCGGGCGGGT

>NZ_CP029197|2|2|861363-861431|CRISPRCasFinder
CCGACGGACGGCGGCTCGCGCCCGC	TCCACCCGGGGGCGGGTGC
CCGGCGGGCGGCGGCTCGGGCGGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015031956.1\|861586_862066_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP029197.1\|WP_145953692.1\|873512_875180_+\|2-polyprenyl-6-methoxyphenol-hydroxylase	unknown	unknown	gnl\|CDD\|235728
NZ_CP029197.1\|WP_041662053.1\|859396_859804_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226318
NZ_CP029197.1\|WP_071891125.1\|862568_864629_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP029197.1\|WP_145953691.1\|864894_866715_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377393
NZ_CP029197.1\|WP_015031950.1\|854335_855391_-\|lactonase-family-protein	unknown	unknown	gnl\|CDD\|378416
NZ_CP029197.1\|WP_051025834.1\|866663_868514_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP029197.1\|WP_015031955.1\|859881_861336_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
NZ_CP029197.1\|WP_051026013.1\|857554_858199_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|227249
NZ_CP029197.1\|WP_015031957.1\|862112_862508_+\|TOBE-domain-containing-protein	unknown	unknown	gnl\|CDD\|133390
NZ_CP029197.1\|WP_078508595.1\|872388_873294_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP029197.1\|WP_041662047.1\|852171_853176_+\|ATPase	unknown	unknown	gnl\|CDD\|225518
NZ_CP029197.1\|WP_015031946.1\|850136_851219_+\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|374209
NZ_CP029197.1\|WP_015031947.1\|851352_852030_-\|uracil-DNA-glycosylase	unknown	unknown	gnl\|CDD\|235376
NZ_CP029197.1\|WP_015031962.1\|868495_871693_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|225107
NZ_CP029197.1\|WP_041662057.1\|871904_872339_-\|DUF2000-domain-containing-protein	unknown	unknown	gnl\|CDD\|378176
NZ_CP029197.1\|WP_041662052.1\|858221_859388_-\|RNA-polymerase-sigma24-factor	unknown	unknown	gnl\|CDD\|227277
NZ_CP029197.1\|WP_041662048.1\|855703_857206_-\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|379231
NZ_CP029197.1\|WP_071891122.1\|853321_854245_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041663608.1\|875295_876723_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366721

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015031956.1\|861586_862066_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.1283e-33
NZ_CP029197.1\|WP_145953692.1\|873512_875180_+\|2-polyprenyl-6-methoxyphenol-hydroxylase	gnl\|CDD\|235728	PRK06184, PRK06184, hypothetical protein; Provisional.	6.34083e-64
NZ_CP029197.1\|WP_041662053.1\|859396_859804_-\|hypothetical-protein	gnl\|CDD\|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	3.69242e-14
NZ_CP029197.1\|WP_071891125.1\|862568_864629_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.01444e-51
NZ_CP029197.1\|WP_145953691.1\|864894_866715_+\|hypothetical-protein	gnl\|CDD\|377393	pfam04632, FUSC, Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, FusC from Burkholderia cepacia and fdt-2 from Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.	0.00775909
NZ_CP029197.1\|WP_015031950.1\|854335_855391_-\|lactonase-family-protein	gnl\|CDD\|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	2.61118e-114
NZ_CP029197.1\|WP_051025834.1\|866663_868514_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.69288e-94
NZ_CP029197.1\|WP_015031955.1\|859881_861336_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	3.20215e-37
NZ_CP029197.1\|WP_051026013.1\|857554_858199_+\|DNA-alkylation-repair-protein	gnl\|CDD\|227249	COG4912, COG4912, Predicted DNA alkylation repair enzyme [DNA replication, recombination, and repair].	4.67575e-42
NZ_CP029197.1\|WP_015031957.1\|862112_862508_+\|TOBE-domain-containing-protein	gnl\|CDD\|133390	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins. Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.	8.99151e-14
NZ_CP029197.1\|WP_078508595.1\|872388_873294_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.58615e-23
NZ_CP029197.1\|WP_041662047.1\|852171_853176_+\|ATPase	gnl\|CDD\|225518	COG2971, COG2971, Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism].	5.69653e-33
NZ_CP029197.1\|WP_015031946.1\|850136_851219_+\|glycosyl-hydrolase	gnl\|CDD\|374209	pfam15902, Sortilin-Vps10, Sortilin, neurotensin receptor 3,. Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.	1.50818e-08
NZ_CP029197.1\|WP_015031947.1\|851352_852030_-\|uracil-DNA-glycosylase	gnl\|CDD\|235376	PRK05254, PRK05254, uracil-DNA glycosylase; Provisional.	4.2456e-124
NZ_CP029197.1\|WP_015031962.1\|868495_871693_-\|AAA-family-ATPase	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.39127e-19
NZ_CP029197.1\|WP_041662057.1\|871904_872339_-\|DUF2000-domain-containing-protein	gnl\|CDD\|378176	pfam09391, DUF2000, Protein of unknown function (DUF2000). This is a family of proteins of unknown function. The structure of one of the proteins in this family has been shown to adopt an alpha beta fold.	1.9886e-56
NZ_CP029197.1\|WP_041662052.1\|858221_859388_-\|RNA-polymerase-sigma24-factor	gnl\|CDD\|227277	COG4941, COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription].	2.30952e-86
NZ_CP029197.1\|WP_041662048.1\|855703_857206_-\|FUSC-family-protein	gnl\|CDD\|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	8.79964e-13
NZ_CP029197.1\|WP_041663608.1\|875295_876723_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	1.0585e-48

>NZ_CP029197.1|WP_015031955.1|859881_861336_-|FAD-dependent-oxidoreductase
MCAARTHGAGNSYWLDSAPPGARPHPPLDGDLSADVVVVGAGIAGLCTAHELVRAGADVVLLEADRIAAGVTGHTTGKLTALHGLRYAALSRAHGAAAAARYADAQQHALDRVVRLAAELGGDAELEHRPAFTYTPDDESVPEIRAEAAAASEAGLDATVVTETGLPYPVAAAVRVDGQLQFHPRRFLLALAEDYVAHGGRLHEGTRVTGLREGAACHLTVEGGVTVDARDVVLATHFPLRCHSSLLVRLSVRRELVVAAAVAERHAPYGMYLTPEGGTRSVRTAPLAEGRRLLIVTGETFEPGSGGVRERYGRLDAWAREHLPGFAEAPEVHRWAAQDVHTPDGLPCVGHEHPDTQHVFLATGFGGWGLSNGVAAGHLLAAHVTGAPRPAWTELVDPRRLLPVRELPGVVRRQTAVARHYVAGFRPGPRCTHMGCELGFNAAEQTWECPCHGSRFATDGRVLQGPATEPLEHPPRPAGKKLGR
>NZ_CP029197.1|WP_041662053.1|859396_859804_-|hypothetical-protein
MAKYLLLKHYRGAPAPVNDVPMDRWTPEEISAHMQYMRDFAGRLEKSGEFVDGQALAPEGTWVRYDGEGRPPVTDGPFAETKDLIAGWMVIDVDGYDRAVELAGELSAAPGAGGKPIHEWLELRPFYGVPPTVTE
>NZ_CP029197.1|WP_041662052.1|858221_859388_-|RNA-polymerase-sigma24-factor
MDEVLLRTLTPGVLGVLVRRGADFAAAEDAVQDALVEAVRVWPEDPPRDPKGWLVTVAWRKFLDAARADTARRRREDRVEEEPEPGPAPAADDTLQLYFLCAHPSLTPSSAVALTLRAVGGLTTRQIAQAYLVPEATMAQRISRAKRTVSGVRFDTPGDLATVLRVLYLVFNEGYSGDVDLSAEAVRLTRQLAAAVDHPEVAGLLALMLLHHARRASRTAPDGSLVPLAEQDRSRWDTAAIAEGVAVLQAALARDRLGEFQAQAAVAALHADAPTAGETDWVQIVEWYDELVRLTDSPVVRLNRAVAVGEADGPRAGLAELAALDAALPRYAAVAAYLHEREGDLATAARLYAEAAHQASDLAERDHLTRQAARLNARLRGGGDEEGR
>NZ_CP029197.1|WP_051026013.1|857554_858199_+|DNA-alkylation-repair-protein
MAELAALEDPKAREVNERHGDDHGVNLGKLRAVAKRLKTQQELARQLWETGDTAARLLALLICRPKAFGRDELDTMLRQARTPKVHDWLVNYVVKKNPHAEELRLAWLADPDPVVASAGWALTTERVAKQPDGLDLAGLLDVIEADMKDAPDRLQWAMNHCLAQIGIEREEHRARAIGIGERLEVLKDYPTSPGCTSPYAPVWITELVRRRQDA
>NZ_CP029197.1|WP_041662048.1|855703_857206_-|FUSC-family-protein
MFVAPDPGHVRLKNSLRAVLGIALAVALAELAGLSLTASITGGLAALLALFTVMDSTVREQAVTTLLLPAAGFPVLALATALHDLTPLRDLAFLAVVFCGVYARRWGPRGHALGIFAFMNFFTTQFLHAVPGQLPELYAAVGIALAAAGAVRFVLWPLERRTPPPAAPAPLPGTGLARVTTRQAIQAAAACAVALAIGQVLSEDRWYWAVGTTWWIFVNTVSRGETLVRGFRRVLGTVIGIAVGMVVAIPLDGAVLPTAALVALCVFGIFYTAPVSYSWMMLAVTVMAGLLYGLLGVLDPALLVLRLEETAVGAVSAALAVLLILPVTTHAINDAWIQRALQGVRSATSASLRRLSGDADADPTPHAAELELLLGRVRLSLAPLVHPLSPFRGRKARARRVLALLDECAEEVRGLAAVAADPAASHDARLAAACWRVEAAVERLTSPRSGSGATERHPADAGTAPVSGQAALGHVSGLEKLLAALDEPLRTPPGSLLVRS
>NZ_CP029197.1|WP_015031950.1|854335_855391_-|lactonase-family-protein
MSDTGTVQGRGAVRAYIGSFTSAGGRGVLAADVDAETGALTVTGASDALADPSFLALAGPVLHAVSETEAGAVAAFDVSGPAPLPLGAPVPVDGAGPTHLALADGHLLTANYTSGSVTALPLAPDGTARAATSVLRHEGGGPVTARQAGPHAHQVLPDPSGRWVVSVDLGTDSVRICALDPATGTLRLHGETALRPGTGPRHLAFHPAGTHAYVLNELEPTLTVCRWDAAAGVLEPLAETPVVPDGTTGPSYPSEVVVAPDGRFLWAAVRGDDTLAVLALDPEGAKASLVATVPCGGTWPRDLTLAPSGRHLYAANERSGDVTWFTLDPETGIPARAGAIEAPAASCVVLG
>NZ_CP029197.1|WP_071891122.1|853321_854245_+|hypothetical-protein
MSSPTGPASGLPVRMPRPRQSGRHRRPEPAAAPEGAPALVLAVPGVPSAAIRSLAEEVVSIARSELPGLDALIGFVEGDDTEYPSLATVLTAAATLRTERYELALAAGREVSAPTGPASVVVPLLAGPDSAQTRQVRQAVMDAGNTAELTDVLGPHPLLAEALHVRLSEAGLARADRARLFTVATAADGIVLATVGGEEAVQAAGITGMLLAARLAVPVMAAALDQDGSIASVAEQLRAAGAEQLALAPYLIGPELAEGLLDEASKEAGCASAEPLGAYPAIGKLVLSQYTATLGLPPQQPQGAPAL
>NZ_CP029197.1|WP_041662047.1|852171_853176_+|ATPase
MNESPGSPGPSGGLVVGVDSGGSGLRIALADAASGAVLGTRASREPVRTGPGGISARHFLDQVLPAVRALTEPHGDRPVVAVAVGAAGMATLGDELRAELPGAFASAWGVRRLALAADAVTAYAGALGQGPGAVVAGGTGMIALGTDLTAWRRADGWGHLLGDCGSGAWIGRAGLEAAMRAHDGRRGGSAALLARAEKLFGPVAGLPGALYPRTDRPAVLASFAPEVARCAAEDPVAADVLARAARHIAEAAEAVCPAGPGARVALTGGLFKMGDPLLVPLRAALAELLPEARTVAPEGDPLAGAVALATALAGGTLRLPEDVALLRRCGGELS
>NZ_CP029197.1|WP_015031947.1|851352_852030_-|uracil-DNA-glycosylase
MTARPLNELVEPGWAEALSPVAGRVAEMGDFLRAEIAAGRTYLPAGQHVLRAFQQPFDEVRVLIVGQDPYPTPGMAIGLSFAVAPEVRSLPGSLENIFRELHTDLGLPRPSNGDLTPWTRQGVLLLNRALTTAPRKPAAHRGKGWEEVTEQAIRALAARGKPLVSILWGRDARNARPLLGKLPAIESAHPSPMSADRGFFGSRPFSRANELLLQQGAQPVDWRLP
>NZ_CP029197.1|WP_015031946.1|850136_851219_+|glycosyl-hydrolase
MPDVLLTVGTRKGLFIGRRHDGRWEFDDPAFPAQAVYSVAIDTRGPVPRLLVGGDSAHWGPSVFHSDDLGRTWTEPARPAVKFPEDTGASLERVWQLHPAPGHAPGVVYAGTEPAALFRSADGGESFELVRPLWEHPTRSQWVPGGGGEAVHTVVTDRRDPDALTVAVSTAGVFRSRDGGAAWEPSNKGVSAVFLPDQHPEFGQCVHKIAQDAGDLDRLYLQNHWGVFRSDDAGASWTDIGAGLPSDFGFAVAAHPHRPDTAYVFPITADSDRVPAGRRCRVFRTTDAGASWEPLSRGLPEGDHYGTVLRDALCTDDADPAGVYFGNRNGEVYASADDGDSWQLLADHLPDVLCVRAAVV
>NZ_CP029197.1|WP_015031956.1|861586_862066_+|Lrp/AsnC-family-transcriptional-regulator
MAVDELDTRILRLLIEQPRTSVREYARILGVARGTVQARIDRLERDGVITATGPVLSPAALGHPVLAFVHVEVTQGHLDEVGDALAAVPEIVEAFSITGGGDLLTRVVARDAGHLEDVIQRLIQLPGVVRTRTEIALRERVAHRLLPLVEAVGRGPGPG
>NZ_CP029197.1|WP_015031957.1|862112_862508_+|TOBE-domain-containing-protein
MQSYTIGQAARLLGVSPDTARRWADAGRVETHRDDNGRRVIDGRALAAFSVEIAANGQGDEEAAYTSARNAFPGIVTAVKLGDVAAQVEIQAGPHRLVSLLTREAVEELGLEVGMQATARVKSTSVHIDRT
>NZ_CP029197.1|WP_071891125.1|862568_864629_-|SpoIIE-family-protein-phosphatase
METHESSSRVPQPPRAAVGDAGVLRELLPIALWREDAEGHIVEWSLAAQDLLGHRPEHVLGRLATPLLVPDANRELAERLTLRVQAGETMVGTLPVRHRDGHTIAMEMWIVPAADPAGRPGAMLIAVETSEVLRMRENLAAMESLFTQSPIGLALLGPDLRFLRVNDALARMNGVAAAEHVGRRLTEVVPGVNAASLESLMRQVMDSGHAVVDARRVGRTPADPERDHIWSCSYAPLIDRTDRRSLGLIASLVDITESQEAHIEVERARHRFALLAEAGARIGTTLDLRQTAEETVRFLVPQLADSADVQMLEAVLAPDDPVASTRGVLRRLAARFPDPTSPTSLLAPGQTFQIPLDSVYEQVVAHGRPTNLYTTDLPALFTDPRTEALRTYFATRIGSARLVPMVARGKVLGAVTVTRLRTREPFDAQDCVLIDEVVARAALNIDNARLYTTQREAALTLQRSLTNSALPAVTGLELTGRYLPASAHDVGGDWFDVIALPGGRTGLVIGDVMGHGIHAAAVMGQLRTAVRTLARHDIPPARMLSSLDAVVADLGEDTMATCLYAVHDPATGGWVIARAGHPPPAVATPDGTITFLDGPPGTPLGTGAHDFGTEEVALPKGGLLVLYTDGLIEARDRDLDEGMRQLARALRPLDRPLDVLCDEILEQLLAAPAQDDVAMLLARTTG
>NZ_CP029197.1|WP_145953691.1|864894_866715_+|hypothetical-protein
MSSRSPDEFRLGARPYDRGSGGGERDGGGDGTGGGVGAGAGTGAGVGAGTGGDGAGTGAGVGAGIGRGTGPEAADGAGARTGEPDDPHELLHRARRLSAHGHPGAGSAWELAAVALRRAGGSLTPGDHADALDATALDCRGAAGPAAGPLFFRAADLHEQAGQRGKALVSRARALVAGPEVGATACARLTELCGRATALHAIGQADAAETATVHLLRGRARADLLDTAPDPAAEADALRAELTRLIAFAAPYRADPAVLGVLADTRALLGRITAPDDPAAALVHLRAALAEHRAGDLPWPATPHELLLAAALRATGAHEEARALLRAALAAGAPDTPLRAADRALLCLALARTVEVDGGPGRTATGARDPEEEMVALLAEAVRHADGPVGDVHVGAVARLRLGVALAERGRYGEASELLARALDGFTAEGDAAARVRVRAWLAQCALGLGEPAGAAREYALAAAEAGRWDERRHREELSHRTAYALALAGSPERAVREWRGLSEAAGAGGTVDPGAPTETETATAASSATATATSATSATARPATESESESAAGGGSGVGGPWQGVYDLPEPFGPPGRYQVNVYGEVGGAWPWATTAPGTRVQGCV
>NZ_CP029197.1|WP_051025834.1|866663_868514_+|serine/threonine-protein-kinase
MAVGHHRPGDPSTGVRVSRVIDGRFELMERLGGGGMGTVWRARDLALHRDVALKEVRPPDPALAEHDVESARTLRERVLREARALARIDHPNVVTIHHIVDAGEGTYPWLVMELVTGGSLQDRLDRGTMTPAEAAGLGRELLSALRAAHARDIEHRDVKPPNVLLRPDGRPVLTDFGIAAIRESTVLTASGSIIGSPDYMAPERIRGGGGSGPAADLWSLGMVLYVAVEGHHPLRRENTLATLAAVLSDDVPPPRRAGALTGVLTALLVRDPAARPTAEELDRALASVAGPDAGARTDAVRDGAPGVTGAAGPGVVADAGGGDDGEATSFRLAPPSGAAAAPAPTPPAGAPVSTAPTGPAGPAAHGAVPGAGSGAFAATAPSVGAPSSRPGERRRRSRTARFLGSAVVVVLAVGIPVAAMNWDWRPGDPGGGASSAPPSQQGPVAQRPKVTTAPVTTPPSKDGDPVRRDLLTPDGVRAAVAAIKAASGGDKVTSFVVYPDYAVAEAVVKGSSKLYDRYIYRGKDVAERQGSGTAFPGAVPADLDDFDWDAVPALMKRAEKELGVDKPTSRYLVLTPASTIFGTKAGMSVYLSDTYGSAYLSADQKGRVTATYPREK
>NZ_CP029197.1|WP_015031962.1|868495_871693_-|AAA-family-ATPase
MDTSADPGCADRAPLAGRAGELARLDALLRGRGTGAGGAGGPVAVDVTGEPGIGKTRLLTEFANRARRAGVTVLRGRATPPDPHPGPSFHPFTDAFADLDPGDRTLFPELAERAEEAGAGGGPWATDPGSEPEPHHDRATSEATRTSRRPGAHRDDDQIRRVAAALGRFAGPAPAPERDPEVAGSAPKREPEVAGPASEREHEVAAADQGRTAVAARGLVIVLDDFHGADPASVALVDHLLRHPLRAPVLLVLARRERQTPPALASVLARAADAGALTRLALGPLTPEECAEGLTPGLTRRQAGEVHALGLGNPLYHRALAHARTHREEAPGAGPVAVLLAELSPLRPLERAVVDSLAVLDGRATTALLAAVAHPANEAAFDAALGELSRRDLVRGGEDGRVLVLRHPALAELLRGTLAPWRRRELHRRAADALARAGAPVTERAPHLVRAATAWDPVVGAELTEAAERIGAADPGRAADWLAAVLGLLPDTAEHRATWRDLTLRRARALGSAGRVAESRDLLHHLIDACDTDATDATGDTDGTDETRTSAVLLCAFMERHLGRYPEADALLRRELERTPGPRPDLRTWLVVEWGCRALFAARYPEVRPVLADTLAEARRRGDDAGAAEVLTLAALGEAYEGETTAARVHAAEAAALTGTFTDGELADHAESLVRLSWTEVFLEQYGTAERHATRGIAMARRAGRPFALSQLLLCSAYVHFLTGRVGAALDLADESLAVARTLGGAELVGFSGAIRAVVLLHARPLGDPEALAAAEEAAATVGTAEGWWATQARCLLGYCVPLGEDPHRVREVLVRAGGDRNLSRLQPSLRPGYLELLAGAALATGDLAEAERVARRALAEAEPLGLPAQRAAALRAWGQVLARRGEPVAAAEALTEAVRESARSGATVREAHSLLLAAPYVRAAGDGTAAAALWRRGRRLAADGGARLLADVADHTWPGTRPAPEGGVAGGRLAVLTPREREISVLVAEGLTNQAVAERLCLSPRTVESHVARVYRKTGVETRAGLASLVVRDGVVRDGVGGVGIGGGVGGVGGGVGGGYFSRG
>NZ_CP029197.1|WP_041662057.1|871904_872339_-|DUF2000-domain-containing-protein
MTTTDAAPVRFDTKIAVLLRDDLETWQRLNVTAFLVSGLGTDLPEVIGEPYADADGTPYLPMFRQPVLVFEGSKETLTAAHARALTRALPRAVFTTDLFTTGNDRDNRAAVRAVGRDGLDLAGLAVYGPRNAVDKVLKGARMHP
>NZ_CP029197.1|WP_078508595.1|872388_873294_+|AraC-family-transcriptional-regulator
MVARQEVSAWRPHVPGVVEVFHAHFTEHAYPMHVHDVWTLLIVDDGAVRYDLNRREHGTPGDTVSLLPPQVPHNGSPATPQGFRKRVLYLDLTQLDESFIGAAVDGPDLVDPLLRRRVGQLHAALADPGGALEAQSRLALVRERLRTHLRPGAVTDARSAGPGVAHRLRELLDARLLDGVTLDEAAGLLHAHPAHLVRAFSRTFGIAPHQYLTARRLERARGLLLDGHPAGEVAVATGFYDQSHLSRSFKRLVGTTPGRFARGGGGTEASVSSTGHFGGVRNSPADLRERFEGLRQSGSRG
>NZ_CP029197.1|WP_145953692.1|873512_875180_+|2-polyprenyl-6-methoxyphenol-hydroxylase
MGTGSGTDGHGDGDVDVCVVGAGPVGLTLAIGLRRLALRVRIVDKAPATKHEARALVLWARAREALDALGVGETLRRHGVELDVVTIHARGRALGELTTGWARSAHARPLNIEQHDIERLLCEELARLGTHVEWNTEVTDVKVHDDRAEFTLRHEDGSVESAAAPWIVGCEGTASVVRDRLGIPFEGRRRTGLQVVQGNARPTWSLGHEPGRGHIFLAPHRSLLVFPLPGGGYRFFCFRDDPDPSLAAAPTLGELRDLVADTARMPELRLGPTEVPWLNRARFSDRVAARLRCGRGLLAGDAAHAWAPVGGHGMNVGILGAHNLAWKLAAVHHGHAREELLDTYSDEQRLLAVRYIREMRFNFMELPLPPLGYRAFTATVPAALARRGFQRRLDLRLSDLGRSHAGGALSWHRPGRRHRTGPRAGDRMPDVTVTTCPVDPTDPAPTRLHTLLGYERWTLVLHAARAHPGVLDRLREACATFPAPVRVLAVTPWDGAEAARLGHPDDLRLVRPDGYVGLVAPLARTALLRDYLAVLAADGPGAVRESRPIRPHRAH
>NZ_CP029197.1|WP_041663608.1|875295_876723_+|FAD-dependent-oxidoreductase
MAGLVAAYELERLGFRVEVIEGSRRLGGRVHTHRFGAAEGAPFVELGAMRIPTGHHRTMHYVEHLGLADQVRPFTTLLSEENAFLATSTGHVRLRDAPRALIADVRASLPGAPYREETVVFGAWLAAVVDAVAPPGLRTGLRADLARNLLDLVEEVDLSPHLLGHAKDRIDVHGLFAAHPGIRAGCGDRLNSFLDDILTETSPELVRLACGMDQLAQRLAARIRGPIWLGQRVSGFEVAPDHVLVRLGGGPSPAVRRCDYVLCTVPFSVLRSLTLTGFDDDKLAVVREVDYCPATKVAVHVREPFWEREGIRGGASFSGGRIRQTYYPPSEAEGTTDPSLGAALLASYTIGEDAEHLGAMPPAQRHRTVVEELGRMHPQLLRRGMVRGVASLAWGGHPWTAGGCTIRWGQDAAACEEQRRRAVRPQHRMFFAGEHCASEPAWIEGAVESALEAVTLIARHAPGRGVVEPAGLEAA

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Crispr_ID: NZ_CP029197_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_3

1638236-1638350

Orphan

Consensus_repeat	Method
AACACGACGCAGGAGGCCGGGCGATGAGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_3

>merge|NZ_CP029197|3|1638236-1638350|CRISPRCasFinder
AACACGACGCAGGAGGCCGGGCGATGAGCGTCAGCCACGACATCTGCTGGGGGTCCGGGGGTCGTCCCCCGGGCGAGCACAGCCTGAACACGACGCAGGAGGCCGGGCGATGAGC

>NZ_CP029197|3|3|1638236-1638350|CRISPRCasFinder
AACACGACGCAGGAGGCCGGGCGATGAGC	GTCAGCCACGACATCTGCTGGGGGTCCGGGGGTCGTCCCCCGGGCGAGCACAGCCTG
AACACGACGCAGGAGGCCGGGCGATGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015032669.1\|1648772_1649816_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176247
NZ_CP029197.1\|WP_150253452.1\|1630158_1634685_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376582
NZ_CP029197.1\|WP_041662213.1\|1641134_1641410_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NZ_CP029197.1\|WP_015032651.1\|1624043_1625444_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
NZ_CP029197.1\|WP_041662209.1\|1627516_1628236_-\|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl\|CDD\|273824
NZ_CP029197.1\|WP_015032660.1\|1639790_1641059_+\|tyrosine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235645
NZ_CP029197.1\|WP_015032662.1\|1641580_1641925_+\|DUF3099-domain-containing-protein	unknown	unknown	gnl\|CDD\|378630
NZ_CP029197.1\|WP_150253454.1\|1634862_1636530_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029197.1\|WP_041662214.1\|1642107_1642323_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015032648.1\|1622994_1623513_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|224973
NZ_CP029197.1\|WP_015032666.1\|1645163_1645538_-\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_CP029197.1\|WP_015032665.1\|1643526_1645167_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NZ_CP029197.1\|WP_051025846.1\|1647458_1648763_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP029197.1\|WP_071891204.1\|1626736_1627513_-\|enoyl-ACP-reductase-FabI	unknown	unknown	gnl\|CDD\|236124
NZ_CP029197.1\|WP_015032652.1\|1625507_1626221_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
NZ_CP029197.1\|WP_015032656.1\|1628426_1630157_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029197.1\|WP_015032653.1\|1626165_1626576_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015032667.1\|1645811_1647350_+\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173799
NZ_CP029197.1\|WP_167537153.1\|1642370_1643492_-\|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl\|CDD\|234672
NZ_CP029197.1\|WP_041663706.1\|1623548_1623752_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015032669.1\|1648772_1649816_-\|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176247	cd08287, FDH_like_ADH3, formaldehyde dehydrogenase (FDH)-like. This group contains proteins identified as alcohol dehydrogenases and glutathione-dependant formaldehyde dehydrogenases (FDH) of the zinc-dependent/medium chain alcohol dehydrogenase family. The MDR family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. FDH converts formaldehyde and NAD to formate and NADH. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
NZ_CP029197.1\|WP_041662213.1\|1641134_1641410_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.56213e-05
NZ_CP029197.1\|WP_015032651.1\|1624043_1625444_-\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.00995e-124
NZ_CP029197.1\|WP_041662209.1\|1627516_1628236_-\|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl\|CDD\|273824	TIGR01830, 3-oxoacyl-_reductase_FabG, 3-oxoacyl-(acyl-carrier-protein) reductase. This model represents 3-oxoacyl-[ACP] reductase, also called 3-ketoacyl-acyl carrier protein reductase, an enzyme of fatty acid biosynthesis. [Fatty acid and phospholipid metabolism, Biosynthesis].	2.7509e-126
NZ_CP029197.1\|WP_015032660.1\|1639790_1641059_+\|tyrosine--tRNA-ligase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_CP029197.1\|WP_015032662.1\|1641580_1641925_+\|DUF3099-domain-containing-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	6.12807e-20
NZ_CP029197.1\|WP_150253454.1\|1634862_1636530_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	9.53844e-12
NZ_CP029197.1\|WP_051025846.1\|1647458_1648763_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.96445e-34
NZ_CP029197.1\|WP_015032648.1\|1622994_1623513_-\|histidine-phosphatase-family-protein	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	1.43499e-48
NZ_CP029197.1\|WP_015032666.1\|1645163_1645538_-\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	1.70834e-35
NZ_CP029197.1\|WP_015032665.1\|1643526_1645167_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP029197.1\|WP_071891204.1\|1626736_1627513_-\|enoyl-ACP-reductase-FabI	gnl\|CDD\|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	2.52265e-165
NZ_CP029197.1\|WP_015032652.1\|1625507_1626221_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.09281e-49
NZ_CP029197.1\|WP_015032656.1\|1628426_1630157_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0.00300132
NZ_CP029197.1\|WP_150253452.1\|1630158_1634685_-\|hypothetical-protein	gnl\|CDD\|376582	pfam01637, ATPase_2, ATPase domain predominantly from Archaea. This family contain a conserved P-loop motif that is involved in binding ATP. There are eukaryote members as well as archaeal members in this family.	0.000454992
NZ_CP029197.1\|WP_015032667.1\|1645811_1647350_+\|S8-family-serine-peptidase	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.86224e-57
NZ_CP029197.1\|WP_167537153.1\|1642370_1643492_-\|GTP-3',8-cyclase-MoaA	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	3.10181e-178

>NZ_CP029197.1|WP_150253454.1|1634862_1636530_-|hypothetical-protein
MHGWVNGVRSWLSALDEDALRSLLTWHQCLRGDRHAHTSDRPPRPTPPSRRELHTARVRLAKAQQGQLTSIAACGLVWAVKALHTEYGFSQRALTEPTLDELLAMLRVLDPPLARCALYGMLLPGTSRLPVGPLAREHEAALQAAADSGPPPDAHAIGPRFEAQEAPPEPPDDSRSFAPSGSGLPTTNPDCEDAASVPAPGPDPLVDLPASLARLTEDGARLAAVLRAAADAVEAGPLPADAPGEGLAAWTEGRARLAAALAAEGFVWEPDLGYADAGAGLARVREARAEQIDALRRKASRYAELLEWADDEEEAADLRRHLERIETQLRELDAPAGEAPAGRTEHGTGDATAMTGGGRVRVGASAIEAVRRAVEPPPPTPLLTHPTPPQGAAPPQGAAPARTAAPAQGAAATQGGGPAQASAPTQSTAPAEASAPAQGAAPAQAPAQGAVPTQSTALAQGAAAGRGGGSAPTSGSAHPSVPAQGTASTQAAPPAECAGPTQGAVPTQSAASAQGAAPAQSAAPAEASAPAQSAASAQASAPAQSTAPAQASAPA
>NZ_CP029197.1|WP_150253452.1|1630158_1634685_-|hypothetical-protein
MPAQGAAPAPVPAPAHPQPAVEEEPWPVGVPAPDWDPYAPWDTGSEPPVGRLLRDGRLAEAYWMTVASRESDVRARTLAFATAAFGCVSDSEATPVQMAHEFDPALAAQDREAHLVALAAALRTGLTARWPHGLISGFVMPSGLTGPWQQLLTVLVAAVRDGRAFEPGMLQGSAEGLEAATREEIGLTARQLLDDLPRRKMKYQRASQVLQYLVGPSGPVREALNEVIEWSAQSPAQYTGTPGFRALGEQLWRAEDIDRLIEDTDALFRTSKQAKEPITAGALRQLHTACRSVGELLMRAEAAHAAARPHQGVSERGIPELASVLRHLAEEPAPAGTGGAALGLLRAWLTGEQVRSADTAADQLRENGGPVPPSDALLRLPDLPRDALGDPDLADPRAARRIAALLTPADAEYALARYLDDGDLHLARALIAAVESEPEEYGCTDPEWGETAARRLAQGHEDWRRAVAERHRAAAGLLAQMRTLNQLAADEEREFVGRLQEFADGEESGRYRFAVESLRALEAELVTLVENYTRQLRENLAQLRSRPDRPLSAADHDRIARLIDEGDTVTAQEFLALATSHKPLPERPADDGSELVAFLAGVTAADAPKAGGEGIDADWWAKRYGDPDASLTPAAGNGLESWAALCTPQGRRGEWQQHIPRVLRLLGLELSTHQVTAERVALGQGMRRFKVRARVAERAGYVAALGSRASSYTVLLIWEEQPADGPLAHLEDADVGANIVLYLHPLGMEGRRGLAESARSFAQQALVVDSAVMGWMAARAPGSFRSLQRVTLPWAAYNPYTPFVAGLVPPEVFYGRDEEMREVMGREGGMFLYGGRQLGKSALLRRVAEIFPSRADAHVAVYLDLLKAEIGHAEAPDRIWSRLVEDLKRKGVFGNKMSEQANPDVVVRNIQSWLDEDDTRRILVLADEADAFLNTDSRRAYRVGSESTFPNVMHFQRLMEQTERRFKIVFAGLHQVQRFGHLSNVSTVHGGPDVLVGPLGTQAAVRLVTEPMAALGYFFERPELVWRILAITNYQANLVQIFCRELVRVLHDRPYTWSGNPVRITEDDVQKVAASETVRRQIAERLRFTINLEDRYRVLALVIALRSLKDNYRGDYSASELLQEAREAWPEGFEMLSAKQAQIFLTEMVGLGLLIQLGDRSRFAVRSPNVVNMLGTREELELELRETEFGLPYDYNPHAARRILGRDARHVQTYSPLTEEQLHETAQSGVSLIGATALHRPELVRRAVAAFAENRGVDVVPYTHGDDLAALLKSRRRKAHVIIADLRGADTDALRETVRALLVHAGPAADRLVRQTERRSGGNENRSVVVVADPAGLAELAADDGHEELSVRWLRPERWTADALRAWSECPFVSREDRDRLVAATGGWPRWMEAAVTDVSVHGATLDNAVERIRTLIAGSRNIAEHLHLSGLDARDLDLLAAWTGYVEEGQGVPRDDVSAAVELSDADTDAWLQHLGRLGVLDETPEGFAVEPVTYRAVRSRAAAGEK
>NZ_CP029197.1|WP_015032656.1|1628426_1630157_-|hypothetical-protein
MTRTEPRTGARAVPPGDLPGVRAQLRGVTADLAAGRNCLWLVTDAMVESGLADELYRGALFGTPVRVDVPPPPSPRARGPEPKREPATGEGAGWATGDGGARADGDAGVWAGGDGGAWADGEGDGWAAGEGDGWADGDAGAWADGDDLPYLDLPDDGFDLDLGWSLDARAPRVPAPRTEQPGPRHDPHGLLARLAKELSVDADEAVATLVDPGRGRRPVVGVRAWTEPDDHDGGTSPGPGTGPGTGTRARGAAVERLFRLLAAAVKDAGLPPGERPRLLVVARLRDLPEPLPDELRHGLGDTAVHWWWGALGRLDTATAVAPILDHGPDTSGRDRDPLAERIRRAVRSETVVEICGPDLELARLLALEWDGAQHTLGAAVGRCLAAAPTPVPSACPPLRRIGALLRPGAELRQAWAAGAVVSWEGRLRAHVGVWHPAAPADGPQPAPDGDVRARLTALVSQAQQRVLAPWIEEARQRLAVRALGHLNRPVATLVADYADRPPAYLGGDPERAFLELQVGELLRAHVSGALALPPRDAALLRLLVTTRNVLAHRSVLYDRTLDELCAELSQADLRAA
>NZ_CP029197.1|WP_041662209.1|1627516_1628236_-|3-oxoacyl-[acyl-carrier-protein]-reductase
MSRSVLVTGGNRGIGLAIARAFAEAGDKVAITYRSGEPPAALTELGCLAVKCDITDGEQVEQAYKEIEEKHGPVEVLVANAGVTKDQLLMRMSEEDFTSVLDTNLTGTFRVVKRANRGMLRAKKGRVVLISSVVGLLGSAGQANYAASKAGLVGFARSLARELGSRNITFNVVAPGFVDTDMTAVLTDDQRAGIVSQVPLGRYAQPEEIAATVKFLASDDASYITGAVIPVDGGLGMGH
>NZ_CP029197.1|WP_071891204.1|1626736_1627513_-|enoyl-ACP-reductase-FabI
MAGILEGKKILITGVLMESSIAFHAAKLAQEQGAEIILTAWPRPTLTERIARKLPQPEKVKVLELDVSNDEHLARLEGQVREHLGDRLDGIVHSIGFAPQDALGGNFLNTPFESVATAMHVSAFSLKSLTMALLPLMSEGGSVVGLTFDAKFAWPQYDWMGPAKAALEATSRYMARDLGKQNIRCNLISAGPLGSMAAKSIPGFGELASVWDSRSPLEWELSDPEPAGRGIVALLSDWFPKTTGEIIHVDGGLHAIGA
>NZ_CP029197.1|WP_015032653.1|1626165_1626576_-|hypothetical-protein
MRAIRHGFGAFASVAVLLTGIAVAAEVRAAPAPAEEVPVAGPATEEPENFGASCRTEIQGSRVTAHCQNPYPRTDRIRLHVECERWWDVDSDSAPVDVGPADYGKVTGRCWKEVRSAWITHQPADQAPEPAVPRGS
>NZ_CP029197.1|WP_015032652.1|1625507_1626221_+|FadR-family-transcriptional-regulator
MALGHPRRAGLSDQVIAELRNQITSGEWPVGSRIPTEPELVEQLGVARNTVREAVRALAHNGLLDIRQGSGTYVIATSELAGVMHRRFAGSDPRHVAELRSTLESAAARFAAGRRTERDLKQLDALLLRREEAWESGDAERFVTADATFHHAVVAASGNEVLTELYADLGDLLRDWLRGDVGQELRPENWMDHARLVDAIREGDAERAAAEAAGYPFMCLRSPAAQPAREPGPPAGG
>NZ_CP029197.1|WP_015032651.1|1624043_1625444_-|MFS-transporter
MPDEPKTLDPAVRPARTSAPAATTTQPGAAATAGDSPAPGPARRLTLGLVTVGLVLAALNLRPAITSLGALLEEVSSDLHMSGTVAGVLTSVPPLCFAVFGITAPRLARRFGPAAVVCAGMAAIFAGLLLRPFAGGTAGFLAASALALMGIAVSNVLMPVIVKRYFPERIGSMTGLYSMALALGTSIAAAATVPMTDALGGDWRVGLGVWAAIAALAVLPWIPLVRDRDRTATTPAGPQAEATATSRAAAGATVRPGAAGATAAAGTGATTAAAPRITRSRTAWALGVFFGLQATGAYITMGWMPQIFRDAGVPASTAGVLLAVTMVMGVPLAFVIPRLATRMKNQGPIVVALGLCGLTGYTGLFLAPSAGAWVWAVLLGISNCSFPLALTMIGMRSRTGAGVVRLSAFAQSVGYLISIPGPLLVGVLYQHSGGWGLPIVLMGSLMIPQMIVGTLAGRDRTVEDEC
>NZ_CP029197.1|WP_041663706.1|1623548_1623752_-|hypothetical-protein
MTARTYTRVRPGATGVDTRLPWWALVLPAAAFVALLLLMAGPAEAHAPSGDAGAGRVLERIQQTLSL
>NZ_CP029197.1|WP_015032648.1|1622994_1623513_-|histidine-phosphatase-family-protein
MSVDTPRRIVLLRHAKADWNQESDHERPLAERGRKDAPVAGRRLAETGIAFDLALCSTATRTRETWKLAVPELPQRPRTVYEERLYEASLGELIALLNETSEDVANLVVIGHNPGMHALADALAGEADGDLPARMNRSGFPTSAFAVLTFTGTWKSVEHGVGRLVDFWTPHA
>NZ_CP029197.1|WP_015032660.1|1639790_1641059_+|tyrosine--tRNA-ligase
MTDIVDELKWRGLFAQSTDEDALRKALADGPVTFYCGFDPTAASLHVGHLVQVLTVRRLQQAGHRPLALVGGATGQIGDPRPTAERTLNDPETVANWVNRLRSQIEPFLSFEGENAAVMVNNLDWTAGMSAIEFLRDIGKHFRVNKMLTKDSVARRLESEQGISYTEFSYQLLQGMDFLELYRRYGCTLQQGGSDQWGNLVAGLDLIHRLEPGAEVHALATPLMVKADGTKFGKTEGGAVWLDPEMTTPYAFYQFWLNVDDRDISTYMRILSFKSREELEELEAQTAERPQARAAQRALAEELTTLVHGADQCAAVINASKALFGQGELTELDEATLAAALSELPHARVTELGQVVDLFTEVGLAPSKSGARRTVKEGGAYVNNVKVTAEDAEVSAEELLHGRWLVLRRGKKNLAAIEFAGA
>NZ_CP029197.1|WP_041662213.1|1641134_1641410_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MSWLWAIIVGFVLGLIAKAILPGKQQIPLWLTTVFGILGSVLGNAVATWIGVNDTKGIDWTRHLLQLIGAVAVVGVGDMLWASMKGNRRRA
>NZ_CP029197.1|WP_015032662.1|1641580_1641925_+|DUF3099-domain-containing-protein
MAKRGGSEVFRITGARQGLADDVRGRQRRYVISMTVRTLSVIAAAVLWNVERHVAIVALALGILLPYIAVVIANAGRETAPSLPSTFVPAPVRPALGAGETSAGGDAERPYGRN
>NZ_CP029197.1|WP_041662214.1|1642107_1642323_+|hypothetical-protein
MSEEKPICSAKGCRADAVWVLAWNNPKLHAPERRKTWLACEEHREHLSQFLGVRGFLKDVVPLADWESDEA
>NZ_CP029197.1|WP_167537153.1|1642370_1643492_-|GTP-3',8-cyclase-MoaA
MRRPRRRVLRRGRAGPRDNLPCSLSEGSRRLEPHADTRTGRGPTVLIDTFGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIRIAVTDLGVTEVRFTGGEPLLRPGLVGIVERCAALEPRPRMSLTTNGIGLKRTAAALKAAGLDRVNVSLDTLRPDVFKTLTRRDRHQDVLDGMAAARDAGLTPVKVNAVLMPGLNADEAPDLLGWAIAEGYELRFIEQMPLDAQHGWKRDGMITAGDILDSLRTRFTLTPEGSQERGSAPAERWVVDGGPHTVGVIASVTRPFCRACDRTRLTADGQVRTCLFATEETDLRATLRSDASDAEVAEIWKKAMWGKKAGSGLDDPSFLQPDRPMSAIGG
>NZ_CP029197.1|WP_015032665.1|1643526_1645167_-|cation-acetate-symporter
MSTPVLLAAGNATSEHRPLIMALFGAFVLATLVITVWAGRQTRSAADFYAGGGQFTGFQNGLAISGDYMSAASFLGISGAIALYGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRFTMGDVLAYRMRQRPVRTAAGTSTIVVSIFYLLAQMAGAGVLVSLLLGITSDGGKIGIVALVGVLMIVYVTIGGMKGTTWVQMVKAVLLIAGTLLITFLILLKFDFNLSQLLGAAATNSGKGDAFLEPGLKYGISGVSKLDFISLGIALVLGTAGLPHILIRFYTVPTAKAARKSVNWAIGIIGAFYLMTIVLGFGAAALLSGDTIKASNKAGNTAAPLTALEVGGGADSTGGAILLAVISAVAFATILAVVAGLTLASSSSFAHDIYANVIKRGKATEKEEMRAARWSTVLIGIVSIALGALARDLNVAGLVALAFAVAASANLPTILYSLFWKRFTTTGALWSIYGGLISSVVLVLFSPVVSGGPASMFKGVDFHWFPLENPGLVSIPLGFLLGWLGSLLSKEEPDAGKYAELEVKSLTGVGVAAAVKH
>NZ_CP029197.1|WP_015032666.1|1645163_1645538_-|DUF485-domain-containing-protein
MATEAPPPPRDGTGSASAPASPTTEQFVEVQEGEEFGELRRTYRSFAFPLTLAFIAWYLLYVLLSNYAGGFMGTKVFGNINVALVLGLGQFATTFLIAWLYSRHAANRLDPKAEAIRERMEADA
>NZ_CP029197.1|WP_015032667.1|1645811_1647350_+|S8-family-serine-peptidase
MAHLGSRRGRALALPVGLALTASLGFLPSGAASAAELSDAPAATVATNGPKLSYVVNVAGGRWTAASVKKAIAAAGGEVVISYDQIGVIVVHSQNPEFAKTIRKARGVVSAGSTRTAPLSVQTDNSVGGGSQALTEAEAKAAAARATDEQDALEPLQWDLPAIKADKAHQRTLGSKRVTVGVIDTGVDDTHPDLAPNFDAKASANCVSGKPDTTAGSWRPNPGESDHGTHVAGTIAAAKNGIGITGVAPGVKVSGIKVSTPDGFFYTEAVVCGFVWAAEHGVDITNNSYYTDPWMFACKNDEDQKALIEAVTRATRYAERKGTVNVAAAGNSKFDLAADEILDNSSPNDTTPGDRVIDPKECLDYPAMLPGVVTVSATGAKNLKSSYSNYGLGVIDIAAPGGDRTQYQAPEAPANNGLILSTTVNGGYNYKAGTSMASPHAAGVLALIKSTHPYASPAALKALLYAQADKLACTNPYDIEGDGKIDAVCEGGKNKNGFYGAGLIDALDAVRR
>NZ_CP029197.1|WP_051025846.1|1647458_1648763_+|CoA-transferase
MDNTVRTGTELLWSALGGDPALVDRVEYGGPGGLLPARLPVLDLARAAVAVAGLAAVERAGLPGPVRVDDGAVATAFVSERHLRVDGRAPVNFAPLSRFWRAADGWVRTHANYPHHRAALLAALGVPDGSVEAVAAAVAGRKAVDVETAVYAAGGLAVALRTPAQWAAHPQGREVAARPLLSQERLDEAPPRRRTGPLRVLDLTRVIAGPVATRTLALLGADVLRIDPPGNPELPDQHADTDVGKRTAALDLERPSDRRTFDELLDSADVLVTGYRPGALDRFGLHRPGLVTARLSAWGDYGPWGERRGFDSLVQVATGIGVTEGSPQEPGALPAQALDHGTGYLLAAAVLRSLTEQDREGGTRLVRLALAQTGHWLTHALPRYEPERYLTESDGPLGRLRHALSPVSYEGGPSSWSRPPGLAGADAPAWASPA
>NZ_CP029197.1|WP_015032669.1|1648772_1649816_-|zinc-dependent-alcohol-dehydrogenase-family-protein
MRATTIHAPFDMRVEDVPDPVVQDPTDVVVRVLRACVCGSDLWAYRGESARQPGQRIGHEFLGIVEAAGSEVTGFTAGDLVVAPFVWSDGTCDYCAEGLQTSCPRGGFWGSVGSDGGQGEAVRVPFADGTLVKLPADAASDDRLLTALLALSDVMGTGHHAALGAGVRAGSTVAVVGDGAVGLCGVLAAKRLGAERIIALGRHTARTDIARRFGATDVVAERGEAAEAAVRELTGGQGAHAVIEAVGTEQSMRTAVAISRDGGSIGYVGVPHGSGTGLDLSVMFDRNIALRGGVAPVRAYIPELLPDVLDGTIDPSPVFDLTVGLEGVPGGYKAMDERTALKVLVKP

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Crispr_ID: NZ_CP029197_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_4

1682514-1682575

Orphan

Consensus_repeat	Method
GGGGCCGGGGTCGGGGCGGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_4

>merge|NZ_CP029197|4|1682514-1682575|CRISPRCasFinder
CGCGCCGGGGTCCGGTCGCTCGGCACGCTCGACGCGCGGGCGGCGGAGCCGGGCCTGGTGGC

>NZ_CP029197|4|4|1682514-1682575|CRISPRCasFinder
CGCGCCGGGGTCCGGTCGCTCGG	CACGCTCGACGCGCG
GGCGGCGGAGCCGGGCCTGGTGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_086024630.1\|1670199_1671609_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015032715.1\|1694626_1695334_-\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP029197.1\|WP_015032707.1\|1685560_1686280_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP029197.1\|WP_041662218.1\|1691633_1692701_-\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243
NZ_CP029197.1\|WP_015032700.1\|1676008_1677517_+\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|234838
NZ_CP029197.1\|WP_015032713.1\|1692813_1693323_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP029197.1\|WP_015032706.1\|1684250_1685249_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|282710
NZ_CP029197.1\|WP_015032710.1\|1689232_1690318_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP029197.1\|WP_015032697.1\|1674525_1674747_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041663712.1\|1681664_1682393_-\|ZIP-family-metal-transporter	unknown	unknown	gnl\|CDD\|223505
NZ_CP029197.1\|WP_041663715.1\|1690423_1691527_+\|alanine--glyoxylate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223153
NZ_CP029197.1\|WP_015032703.1\|1680261_1681662_+\|cobyrinate-a,c-diamide-synthase	unknown	unknown	gnl\|CDD\|234896
NZ_CP029197.1\|WP_015032699.1\|1675049_1676012_+\|cobalamin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|234919
NZ_CP029197.1\|WP_015032708.1\|1686371_1688513_+\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP029197.1\|WP_015032695.1\|1671737_1672865_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224423
NZ_CP029197.1\|WP_015032696.1\|1673247_1674513_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NZ_CP029197.1\|WP_015032701.1\|1677590_1679660_+\|putative-cobaltochelatase	unknown	unknown	gnl\|CDD\|274135
NZ_CP029197.1\|WP_015032709.1\|1688509_1689079_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|379237
NZ_CP029197.1\|WP_015032702.1\|1679659_1680268_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|235662
NZ_CP029197.1\|WP_015032714.1\|1693441_1694500_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|223594

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015032715.1\|1694626_1695334_-\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	7.22738e-85
NZ_CP029197.1\|WP_015032707.1\|1685560_1686280_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	2.19617e-52
NZ_CP029197.1\|WP_041662218.1\|1691633_1692701_-\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	1.89503e-178
NZ_CP029197.1\|WP_015032700.1\|1676008_1677517_+\|cobyric-acid-synthase	gnl\|CDD\|234838	PRK00784, PRK00784, cobyric acid synthase.	0
NZ_CP029197.1\|WP_015032713.1\|1692813_1693323_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.76209e-22
NZ_CP029197.1\|WP_015032706.1\|1684250_1685249_-\|hypothetical-protein	gnl\|CDD\|282710	pfam04886, PT, PT repeat. This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.	0.00167795
NZ_CP029197.1\|WP_015032710.1\|1689232_1690318_-\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	4.26029e-63
NZ_CP029197.1\|WP_041663712.1\|1681664_1682393_-\|ZIP-family-metal-transporter	gnl\|CDD\|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	1.43838e-11
NZ_CP029197.1\|WP_041663715.1\|1690423_1691527_+\|alanine--glyoxylate-aminotransferase-family-protein	gnl\|CDD\|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	8.63143e-81
NZ_CP029197.1\|WP_015032703.1\|1680261_1681662_+\|cobyrinate-a,c-diamide-synthase	gnl\|CDD\|234896	PRK01077, PRK01077, cobyrinate a,c-diamide synthase.	0
NZ_CP029197.1\|WP_015032699.1\|1675049_1676012_+\|cobalamin-biosynthesis-protein	gnl\|CDD\|234919	PRK01209, cobD, cobalamin biosynthesis protein.	7.7846e-120
NZ_CP029197.1\|WP_015032708.1\|1686371_1688513_+\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	4.3221e-159
NZ_CP029197.1\|WP_015032695.1\|1671737_1672865_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	0.000104424
NZ_CP029197.1\|WP_015032696.1\|1673247_1674513_+\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	1.01807e-94
NZ_CP029197.1\|WP_015032701.1\|1677590_1679660_+\|putative-cobaltochelatase	gnl\|CDD\|274135	TIGR02442, Uncharacterized_protein_Rv2850c/MT2916, cobaltochelatase subunit. Cobaltochelatase is responsible for the insertion of cobalt into the corrin ring of coenzyme B12 during its biosynthesis. Two versions have been well described. CbiK/CbiX is a monomeric, anaerobic version which acts early in the biosynthesis (pfam06180). CobNST is a trimeric, ATP-dependent, aerobic version which acts late in the biosynthesis (TIGR02257/TIGR01650/TIGR01651). A number of genomes (actinobacteria, cyanobacteria, betaproteobacteria and pseudomonads) which apparently biosynthesize B12, encode a cobN gene but are demonstrably lacking cobS and cobT. These genomes do, however contain a homolog (modelled here) of the magnesium chelatase subunits BchI/BchD family. Aside from the cyanobacteria (which have a separate magnesium chelatase trimer), these species do not make chlorins, so do not have any use for a magnesium chelatase. Furthermore, in nearly all cases the members of this family are proximal to either CobN itself or other genes involved in cobalt transport or B12 biosynthesis.	0
NZ_CP029197.1\|WP_015032709.1\|1688509_1689079_+\|acetyltransferase	gnl\|CDD\|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.90839e-55
NZ_CP029197.1\|WP_015032702.1\|1679659_1680268_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|235662	PRK05986, PRK05986, cob(I)yrinic acid a,c-diamide adenosyltransferase.	2.98828e-106
NZ_CP029197.1\|WP_015032714.1\|1693441_1694500_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	1.25339e-38

>NZ_CP029197.1|WP_041663712.1|1681664_1682393_-|ZIP-family-metal-transporter
MAVVVALGAFLMTLFGGWVAQRVTDRRHLVLGLAGGLMLGVVGLDLLPEALEAAGDEVFGVPEALLLFVGGFLLAHAVERLLAVRRAAHGVAADERVPQVGMTAAAAMVGHSLMDGIALGAAFQVGGGMGATVALAVITHDFADGFNTYTITSLYGNARRKALTMLVADALAPLVGAASTLLFTLPEELLGGYLGFFGGALLYLAAAEILPEAHHDHPARSTLLCTVGGVGFIWLVVGVSGG
>NZ_CP029197.1|WP_015032703.1|1680261_1681662_+|cobyrinate-a,c-diamide-synthase
MVARLVIAAPSSGAGKTTVATGLMAAFAGRGLAVSPHKVGPDYIDPGYHALATGRPGRNLDAYMCGTGLIAPLFEHGARGCDLAVVEGVMGLYDGAADQGELASTAQVSKLLKAPVVLVVDASSQSRSVAALVHGFASWDPEVRIGGVILNKVATDRHEHLLREALGESGVPVLGVLRRAPAVATPSRHLGLVPVAERQAAAVAAVAAQAEQVLAGCDMEALLALARSAPELHAEPWVPHGSGAGVPQGGTGGHSPAPGPRTADRSGRRPVVAVAGGAAFTFSYAEHTELLRAAGADVVTFDPLRDEALPEGTSGLVIGGGFPEMYGEQLSANEPLRKAVAELARSGAPVAAECAGLLYLARSLDGHPMCGVLDADARMSERLTLGYRDAVAVSDSVLAPAGARMRGHEFHRTVVEPGAGATAAWGLRQPERRVEGFVQGGVHASYVHTHWAGAPEVAARFVEHCA
>NZ_CP029197.1|WP_015032702.1|1679659_1680268_+|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MPQGQPTVVPDDGLTTRQRRNRALVMVHTGVGKGKSTAAFGMALRAWNQGWPIGVFQFVKSAKWRVGEENALKALGETGKGGTVTWNKMGEGWSWIQREVAEGEQSHEDKAREGWEQVKRDLAEEKYTFYVLDEFAYLLHWGWIDVKEVVEVLRDRPGQQHVVITGRNAPQELIDFADLVTDMSKVKHPMDAGQKGQRGIEW
>NZ_CP029197.1|WP_015032701.1|1677590_1679660_+|putative-cobaltochelatase
MNTRYPFTAVVGMDDLRLALLLNAVSPAVGGVLVRGEKGTAKSTAVRALAELLPAVPVVAGCRFSCDPASPDLGCPDGPHGTEPGVQRPARMVELPVGASEDRLVGSLDIEKALADGVKAFEPGLLAAAHRGILYVDEVNLLSDHLIDHLLDAAAMGSSYVEREGVSVRHAARFLLVGTMNPEEGELRPQLLDRFGLTVEVAASREPEQRVEVVRRRLAYEDDPGAFAARWADEETALRERIVTARELLPEVTLGDAVLLQIAATCAAFEVDGMRADIVMARTATALAAWAGRTEVTSEDVRQAALLALPHRRRRSPFDAPGLDEDKLDETLEQFKGQEPDEDPEPDGPGDGGPGDGGPGGGVPPQGDGPAAENAPAAEETSPPSPEPASEPAPASAPQGAGSGERAAVAAGEPFRTKVLSVPGLGEGAAGRRSRARTEHGRTTGSVRPRGALTKLHLAATVQAAAPHQKARGRTGPGLVVRRDDLRQATREGREGNLVLFVVDASGSMAARQRMSAVKGAVLSLLLDAYQRRDKVGLITFRGRDAEVALPPTSSVDAAAARLEKLPTGGRTPLSAGLLKAHDVLRVERLRDASRRPLLVVVTDGRATGGGADPVALAGRAARLHAAEGTASVVVDCETGPVRLGLARELARELGGTAVTLDELRADSIAGLVRDVRDVQAGQTTRRAA
>NZ_CP029197.1|WP_015032700.1|1676008_1677517_+|cobyric-acid-synthase
MRGGGLLVAGTTSDAGKSVVTAGICRWLVRQGIKVAPFKGQNMSLNSFVTREGAEIGRAQAMQAQAARVEPTALMNPVLLKPGSDRSSQVVLMGKPVGELSARGYHGGRQKELFEPVLACLEELRSTYDAVICEGAGSPAEINLRRTDIVNMGIARAARLPVVVVGDIDRGGVFAQFFGTTALLAPEDQELIAGYLVNKFRGDVTLLEPGLDMLHGLTGRRTFGVLPYAHGLGIDEEDGLRVSLRGAVRESVVAPPVGEDVLRVAVCAVPLMSNFTDVDALAAEPGVVVRFVDRAEELVDADLVVVPGTRGTVRALAWLRERGLADALVRRAAEGRPVLGVCGGFQVLGEHIEDEVESKAGAVDGLGLLPVRVRFAPGKTLARPVGEALGERVEGYEIHHGVADVRGGEPFLDGCRVGAVWGTHWHGSLESDGFRRAFLREVAAAAGRRFVPAPDTSFGALREEQLDRLGDLIEEHADTDALLRLIEQGPPKGLPFVPPGAP
>NZ_CP029197.1|WP_015032699.1|1675049_1676012_+|cobalamin-biosynthesis-protein
MPGRSRTTGVFAYGAAAGLAVDLLVGDPRRGHPVAAFGRAAAAVENRLHHDHRGWGALHTAVCAGTTVALGALAARAVRDRPAAAVALTAASVWAVVGGTTLGREARAIGGALAAGDLDVARERLPHLCGRDPHSLDGPAMARAVVESVAENTSDAVVGALFWGAVAGVPGLVGFRAVNTLDAMVGHKSPRHRRFGWASARLDDVAGWPGARLTAALATVAGGDPRGALKAWRADAARHPSPNAGPVEASFAGALGVRLGGTLSYGGRVEHRPVLNGEGRPVEVADIDRAVRLSRRVTGLTLAVCVGGRLIASALKRRNA
>NZ_CP029197.1|WP_015032697.1|1674525_1674747_+|hypothetical-protein
MKIDWAALGSVFGVSLVATVALVGLFTLGVIGLSKQERAAAQGGSAALARTGAYACFGLCLAAVAYGIYLIVV
>NZ_CP029197.1|WP_015032696.1|1673247_1674513_+|inorganic-phosphate-transporter
MEHITLLLAIVVVTALVFDFTNGFHDTANAMATTISTGALKPKTAVAMSAVLNLVGAFLSVEVAKTISGGIINEEGIRTEVIFAALVGAILWNLLTWLLGLPSSSSHALFGGLIGAAVMSAGWSAVNGPTIVTKVLIPAVAAPIVAGLAAMLATRLTYKLGAKTDEKHTAKGYRVGQIASAGLVSLAHGTNDAQKTMGIITLALITGGAIAPGSNPPLWVIVSAGVAIAAGTYLGGWRIIRTMGKGLTDLRPQQGFAAQTSAATVILASSHLGFSLSTTQSCSGAVMGAGLGRKGGVVRWSTATRMFVAWGLTLPAAGLVGAGAEFLTKQGPWGIAAVAVLLIAGSGVIWSLSRRKPVDHHNVTADDLDEPAGVVTTAIAAVTPPPAAGSVAAVTDEDLKTTIPAPVPTDPTAPPAPAAAV
>NZ_CP029197.1|WP_015032695.1|1671737_1672865_-|alpha/beta-fold-hydrolase
MRPATATAAAVTTLLGVGAAAIAAGRYASDVALRAPSGRPLPGDPRLTVHATGPERITLTRSLASLRPGTYGIEGPGLHAVVGPVLDRVPHTADTVVRRLERVEQGVLGPGSRVRLTPQLHIGTPISALGLAHEDVEMPGELGPLPAWLVAAPRTTWVIALHGLGTTREHPLNVVPFYNRRKIPVLLPAYRGDEGAPASPDGLAHLGDSEWRDVDAAIRYAVHRGAAKVVLHGWGTGASMALRAAAESGVRDRISGLVLDSPVLDWEATLRNLAAARHVPAPLLPLAVRAAQGRTGPHGDLLDAASAPDALRVPALLFHGPDDTLAPWEPSVELAARRPDLVNLQVVRNAPHAAMWNADPVRYEEALRRFLTPLL
>NZ_CP029197.1|WP_086024630.1|1670199_1671609_-|hypothetical-protein
MARNSRLRLVRPRALATARRAVTTRRTRPAPRPPEGTPPRAELARQARHVLADAVRIARWAAVERGAETALRTGPGAAPAHERAAAALDLTPEQIRAGWDRARLAGLVELHGDTARPGWRLHAWDRDDSAVLRGWVALFDAWSLVHPAAEGVEPSAVAEVVEAVPQVLSLLQLSQGPVLVPALLDLLGQRVEELREERCEVPVTGPAPETPGAPAGAAPGAADAADGLPALLDWALEGLAAVGALTLDRGPEGRHATLTPLGNWAVWVKLEQICVAAQSPAGNIEQSAEDMLRGCARLTPGPARAEYRAWLAARTLSSAVAELLAVARGEDALLRGLAFEALRVVGAPAEAEVRATVAEPSLRPYALLWLAEYEGADPDDAQEVLTREESTWLWVDTAAAVADHGESALLVRHLESAVQGTVPALLDEVRAVGHPRTVQVLVALAAAHPDPALAKAVRRAAFQVHTGGA
>NZ_CP029197.1|WP_015032706.1|1684250_1685249_-|hypothetical-protein
MNSNTFGLPVRRTAAAATVAALTVGPVLLAAPAAHATGGEGRATAVVLRTGLDVSLLDKTVDVPLRVSLNEVRAPRTESETALSVKVQGAEGNKPIDILAADVATSKATVDEAKAEGYVNLVKARVHVPGIPLLSLIEVEKVTSKALCETGKKPVAESNVLGHVTVFGKKTTLSTGGRTQVTVPGVGKVTLDLSRTSTTSRTAAATALELAVEVDPLKLGVAEVNGTVTLAQATCETPKGPAPTQKPTEKPTQPPTQEPSERPSEQPTQQPTAKPSDAGGIKTNNGGTTPTQNLAETGGSSTTPYIAGGALALLVAGGGALALTRSRARSRG
>NZ_CP029197.1|WP_015032707.1|1685560_1686280_-|siderophore-interacting-protein
MGHGWQGAVLKLMRGKDFTFTVTGAEQVTEDYRRVRFTDGGLLAAAGIHPTMWVRLWFENAGKPHQRAYTLVDPDLEAGTFSLEFALHDGVASHWARGCAPGDTVEATLQGTGFEAPAPLPGRLLVVGDPASLPAVNSLLDALPGVPATVWFETQHASDEELPIRLDPEHHELRRVPRRNDGADLVARVKAELPGLADSDPYVWIACDTATTRTLATYARKELALPKERVHALGYWRAS
>NZ_CP029197.1|WP_015032708.1|1686371_1688513_+|penicillin-acylase-family-protein
MDGIGVSVSIEVYRDAWGVPHLRAADPDELAFAQGRVTAHDRAWQLEVERHRAQGTTAAFLGAAEVAWDTFARRSRLADTARRCFERLERDDPDTAAWVRAYVAGVNDGLPEGAGRAPEFAETGLTPGRWEPWTPLAVWLTTHILFAGFPTKLWREEVARRLGEEWTELFATDGPGTSGSNGWLVAGERTASGAALIAGDPHRFIEAPGVYQQIRLACPSYDVVGIAVPGIPGLAHFGHTGPVAWAITNAMSDYQDLYRERLRRLPDGGIEAYGPEGHRPATAHRETIEVAGGNPVVIEVVETDRGPVIIGLDDEPAGEAPEDAPWEAVSLRYPPRVTGELGFGVLPALLRARTVADVDTALDGWIEPVNVVLAADTRGGLLHRVAGHVPVRHRTNSLRIVPAWDPAHAWQDAPAPLPRAEVDGHAVMANARGLAAPLGIEFAPPHRAARIDALLGASAEWTPEAMTAVHRDTDNPSAARLLAAVDRAGAPGPDGAGSPAALSPAASAVRERLLGWDRRMDADSVDAGLYAAVRGAVVRRLAAHEAFAALREPAPYPEVFRPWLALGPRVAYALETLLVAGPVPAGDVDRIVREALDEVGAGEPPAAWGVTHRLAPWQALPDPDDAKWPGLGGDHDCVLSTSSVPGWTDRSARASAARYVWDLADRERSGWIVPFGASGVPGDPHRDDQLPLWLRGELAPVTTDWQNLTKEQG
>NZ_CP029197.1|WP_015032709.1|1688509_1689079_+|acetyltransferase
MTTATAAYVHRIEGFGTVTVRPVEPERDAPLLHAWVNEERSRFWGMVGTTVEQVRDVYAHLDSLTTHHGFLVSLDGEPVALLQTYDPEADRVSECYEVEPGDVGAHFLVAPNPAPRPGFTGMLLTALIAFALKDRTRLVVEPDAANEKAIARMVRAGFELGPEVVLPEVDLPEVFIPEKKARLAFLTRR
>NZ_CP029197.1|WP_015032710.1|1689232_1690318_-|amidohydrolase-family-protein
MSDHAVLHVKGRVLVGPEDVRDELWCVDGRITFDRPAAEAVTVEGWVLPGLVDAHCHVGLDRHGPVDAATSEKQALTDRDAGTLLIRDAGSPSDTRWIDEREDLPKIIRAGRHIARTRRYIRNYAHEIEPADLVAYVGREARRGDGWVKLVGDWIDREAGDLTACWPRPEVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTEDTIPLFAERGVAIVPTLVNIATFPHLADGGEEKFPRWSAHMRRLHERRYDTVRAAFDAGVPVFVGTDAGGSLAHGLVAEEVEELTKAGIPPLDALAATAWRARAWLGRPSLEEGAPADLVVYGEDPRADVRVLAAPRRVVVNGRVIG
>NZ_CP029197.1|WP_041663715.1|1690423_1691527_+|alanine--glyoxylate-aminotransferase-family-protein
MTHPLLDLAPLTAAHFASIERRVAALLSTEQDVVITQGEALLPLEGCIRSGARAGSTALNVVTGPYGQTFGNWLRDCGATVVDLEVPFHTAVTAAQVEQALAAHPEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDMCIIGAQKAMGGPAGVSAVSVSARAWERFAANPAAPRRSYLSLLDWKERWIDGGRKALLHAPAQLEMLALEACVERIEAEGLDALMARHASAAAATRAGALALGGGLEPFVYEAKDAAPVATTLRVPAGVDASALVAKALAADPSLPLIAGGGALAGEMIRVNHYGVDATPGAVQSSLAALGAALGEAGRAVDLEGARRAVTEAWAV
>NZ_CP029197.1|WP_041662218.1|1691633_1692701_-|alkene-reductase
MTTAFDPVDLAGTRLSNRIAMAPMTRSRADAVRRTPTALVAEYYAQRASAGLIISEGVHPVAEGQGYPFTPGIHSREQIAAWREVTDAVHERGGRIFAQLMHSGRIGHPDLLDGDLHPVGPSAVAPAGQAFTPEGPKDYVTPRVLTGDEVRETVAGFAAAARHAVEAGFDGVEIHGANGYLIQQFLATGSNHRTDEWGGPVENRIRFAVEVVRAVAAEIGPERTGLRISPANTLNDIAETETEELYTALLDAIEPVGIAYLHVLETAPELRPLVLDLRKRFAGTFILNPSTEGPTSSESLALIEDGTTDLVAFGRLFIANPDLPARLRADGPYNEPDGATMYGGDHRGYVDYPAL
>NZ_CP029197.1|WP_015032713.1|1692813_1693323_+|winged-helix-turn-helix-transcriptional-regulator
MPANDPACTDTTPSAARGGPVGIALARVARMHRLAAGRRLRELDLYPGQEMMMMRLWDCGPVRQSELIQSLGLDASTVTKMLQRLEQCGHVRRGPDPADRRAVLVEATEEGRSLRAGVEGVWSDLEKVSLNGLDPADRAELARLLGLVADNLRAEAGESGDCPPPPRGC
>NZ_CP029197.1|WP_015032714.1|1693441_1694500_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MDSLEEPLGGAEFAPEHTYLNTSACALLPRRTIEAVVLLAEETAAGRPDGAGDFAVVDEARATYARLMGVTPERVAVGSSVAVHCGMIAQSMPAGAEILFPEGDFSSVITPFTIRGDLKVRFAPLDRLAESVGPDTALVAFSAVQSADGRTADFAAIRAAAAAHGARTLLDATQSAGWLPLRAGEWDYTVAGGYKFLLCPRGASFLTVTEEAQDSLLAIHANWVTGEERWVNSYGPVRELARSARRFDEPPAFLSYHGAARSLALLEEIGIERIEAHVKGLAARFRAGLVALGHAPVMDESAVVAVPGLGDREDALREADVLLSARAGNLRASFHLYNTAADVDRALAALKA
>NZ_CP029197.1|WP_015032715.1|1694626_1695334_-|DsbA-family-oxidoreductase
MRVEIWSDIACPWCYIGKARFEKGLAAFAHRDDVEVVHRSFELDPNRAKGDTGPVLEMLAKKYGRTLEEARAMEAHVASNAHAEGLGYRTEGRDHGNTFDIHRLLHLARDRGLQNELLDLAYRANFAEERSVFDPETLVTLGVEAGLDEAEVRAVLADDSAYAEAVREDEREAAELGANGVPFFVLDRRYGISGGQPAEVFTQALEQAWQGRVLQPVGGDAAVCDPDGSCEVPGA

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Crispr_ID: NZ_CP029197_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_5

1682675-1682833

Orphan

Consensus_repeat	Method
GGGGCCGGGGTCGGGGCGGGCGG	CRISPRCasFinder

3 spacers

The CRISPR arrays of NZ_CP029197_5

>merge|NZ_CP029197|5|1682675-1682833|CRISPRCasFinder
GGGCACGGCGTCGGTGGCGGAGGCGGCGGCACTGCTCGCGGCGGCGGGTGACGGCCCTGGGGCCGGGGCCGGGGTCGGGGCGGGCGGTGACGGCACCGGGGCTGCGGCCGGGGTCGGGGCGACGGGTGACGGCCCCGGGGCTGCGGCCGGGGTCGGGGC

>NZ_CP029197|5|5|1682675-1682833|CRISPRCasFinder
GGGCACGGCGTCGGTGGCGGAGG	CGGCGGCACTGCTCGCGGCGGCGGGTGAC
GGCCCTGGGGCCGGGGCCGGGGT	CGGGGCGGGCGGTGACGGCACC
GGGGCTGCGGCCGGGGTCGGGGC	GACGGGTGACGGCCCC
GGGGCTGCGGCCGGGGTCGGGGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_086024630.1\|1670199_1671609_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015032715.1\|1694626_1695334_-\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP029197.1\|WP_015032707.1\|1685560_1686280_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP029197.1\|WP_041662218.1\|1691633_1692701_-\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243
NZ_CP029197.1\|WP_015032700.1\|1676008_1677517_+\|cobyric-acid-synthase	unknown	unknown	gnl\|CDD\|234838
NZ_CP029197.1\|WP_015032713.1\|1692813_1693323_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP029197.1\|WP_015032706.1\|1684250_1685249_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|282710
NZ_CP029197.1\|WP_015032710.1\|1689232_1690318_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP029197.1\|WP_015032697.1\|1674525_1674747_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041663712.1\|1681664_1682393_-\|ZIP-family-metal-transporter	unknown	unknown	gnl\|CDD\|223505
NZ_CP029197.1\|WP_041663715.1\|1690423_1691527_+\|alanine--glyoxylate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223153
NZ_CP029197.1\|WP_015032703.1\|1680261_1681662_+\|cobyrinate-a,c-diamide-synthase	unknown	unknown	gnl\|CDD\|234896
NZ_CP029197.1\|WP_015032699.1\|1675049_1676012_+\|cobalamin-biosynthesis-protein	unknown	unknown	gnl\|CDD\|234919
NZ_CP029197.1\|WP_015032708.1\|1686371_1688513_+\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP029197.1\|WP_015032695.1\|1671737_1672865_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224423
NZ_CP029197.1\|WP_015032696.1\|1673247_1674513_+\|inorganic-phosphate-transporter	unknown	unknown	gnl\|CDD\|376541
NZ_CP029197.1\|WP_015032701.1\|1677590_1679660_+\|putative-cobaltochelatase	unknown	unknown	gnl\|CDD\|274135
NZ_CP029197.1\|WP_015032709.1\|1688509_1689079_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|379237
NZ_CP029197.1\|WP_015032702.1\|1679659_1680268_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl\|CDD\|235662
NZ_CP029197.1\|WP_015032714.1\|1693441_1694500_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|223594

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015032715.1\|1694626_1695334_-\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	7.22738e-85
NZ_CP029197.1\|WP_015032707.1\|1685560_1686280_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	2.19617e-52
NZ_CP029197.1\|WP_041662218.1\|1691633_1692701_-\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	1.89503e-178
NZ_CP029197.1\|WP_015032700.1\|1676008_1677517_+\|cobyric-acid-synthase	gnl\|CDD\|234838	PRK00784, PRK00784, cobyric acid synthase.	0
NZ_CP029197.1\|WP_015032713.1\|1692813_1693323_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.76209e-22
NZ_CP029197.1\|WP_015032706.1\|1684250_1685249_-\|hypothetical-protein	gnl\|CDD\|282710	pfam04886, PT, PT repeat. This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.	0.00167795
NZ_CP029197.1\|WP_015032710.1\|1689232_1690318_-\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	4.26029e-63
NZ_CP029197.1\|WP_041663712.1\|1681664_1682393_-\|ZIP-family-metal-transporter	gnl\|CDD\|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	1.43838e-11
NZ_CP029197.1\|WP_041663715.1\|1690423_1691527_+\|alanine--glyoxylate-aminotransferase-family-protein	gnl\|CDD\|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	8.63143e-81
NZ_CP029197.1\|WP_015032703.1\|1680261_1681662_+\|cobyrinate-a,c-diamide-synthase	gnl\|CDD\|234896	PRK01077, PRK01077, cobyrinate a,c-diamide synthase.	0
NZ_CP029197.1\|WP_015032699.1\|1675049_1676012_+\|cobalamin-biosynthesis-protein	gnl\|CDD\|234919	PRK01209, cobD, cobalamin biosynthesis protein.	7.7846e-120
NZ_CP029197.1\|WP_015032708.1\|1686371_1688513_+\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	4.3221e-159
NZ_CP029197.1\|WP_015032695.1\|1671737_1672865_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	0.000104424
NZ_CP029197.1\|WP_015032696.1\|1673247_1674513_+\|inorganic-phosphate-transporter	gnl\|CDD\|376541	pfam01384, PHO4, Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.	1.01807e-94
NZ_CP029197.1\|WP_015032701.1\|1677590_1679660_+\|putative-cobaltochelatase	gnl\|CDD\|274135	TIGR02442, Uncharacterized_protein_Rv2850c/MT2916, cobaltochelatase subunit. Cobaltochelatase is responsible for the insertion of cobalt into the corrin ring of coenzyme B12 during its biosynthesis. Two versions have been well described. CbiK/CbiX is a monomeric, anaerobic version which acts early in the biosynthesis (pfam06180). CobNST is a trimeric, ATP-dependent, aerobic version which acts late in the biosynthesis (TIGR02257/TIGR01650/TIGR01651). A number of genomes (actinobacteria, cyanobacteria, betaproteobacteria and pseudomonads) which apparently biosynthesize B12, encode a cobN gene but are demonstrably lacking cobS and cobT. These genomes do, however contain a homolog (modelled here) of the magnesium chelatase subunits BchI/BchD family. Aside from the cyanobacteria (which have a separate magnesium chelatase trimer), these species do not make chlorins, so do not have any use for a magnesium chelatase. Furthermore, in nearly all cases the members of this family are proximal to either CobN itself or other genes involved in cobalt transport or B12 biosynthesis.	0
NZ_CP029197.1\|WP_015032709.1\|1688509_1689079_+\|acetyltransferase	gnl\|CDD\|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.90839e-55
NZ_CP029197.1\|WP_015032702.1\|1679659_1680268_+\|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl\|CDD\|235662	PRK05986, PRK05986, cob(I)yrinic acid a,c-diamide adenosyltransferase.	2.98828e-106
NZ_CP029197.1\|WP_015032714.1\|1693441_1694500_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	1.25339e-38

>NZ_CP029197.1|WP_041663712.1|1681664_1682393_-|ZIP-family-metal-transporter
MAVVVALGAFLMTLFGGWVAQRVTDRRHLVLGLAGGLMLGVVGLDLLPEALEAAGDEVFGVPEALLLFVGGFLLAHAVERLLAVRRAAHGVAADERVPQVGMTAAAAMVGHSLMDGIALGAAFQVGGGMGATVALAVITHDFADGFNTYTITSLYGNARRKALTMLVADALAPLVGAASTLLFTLPEELLGGYLGFFGGALLYLAAAEILPEAHHDHPARSTLLCTVGGVGFIWLVVGVSGG
>NZ_CP029197.1|WP_015032703.1|1680261_1681662_+|cobyrinate-a,c-diamide-synthase
MVARLVIAAPSSGAGKTTVATGLMAAFAGRGLAVSPHKVGPDYIDPGYHALATGRPGRNLDAYMCGTGLIAPLFEHGARGCDLAVVEGVMGLYDGAADQGELASTAQVSKLLKAPVVLVVDASSQSRSVAALVHGFASWDPEVRIGGVILNKVATDRHEHLLREALGESGVPVLGVLRRAPAVATPSRHLGLVPVAERQAAAVAAVAAQAEQVLAGCDMEALLALARSAPELHAEPWVPHGSGAGVPQGGTGGHSPAPGPRTADRSGRRPVVAVAGGAAFTFSYAEHTELLRAAGADVVTFDPLRDEALPEGTSGLVIGGGFPEMYGEQLSANEPLRKAVAELARSGAPVAAECAGLLYLARSLDGHPMCGVLDADARMSERLTLGYRDAVAVSDSVLAPAGARMRGHEFHRTVVEPGAGATAAWGLRQPERRVEGFVQGGVHASYVHTHWAGAPEVAARFVEHCA
>NZ_CP029197.1|WP_015032702.1|1679659_1680268_+|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MPQGQPTVVPDDGLTTRQRRNRALVMVHTGVGKGKSTAAFGMALRAWNQGWPIGVFQFVKSAKWRVGEENALKALGETGKGGTVTWNKMGEGWSWIQREVAEGEQSHEDKAREGWEQVKRDLAEEKYTFYVLDEFAYLLHWGWIDVKEVVEVLRDRPGQQHVVITGRNAPQELIDFADLVTDMSKVKHPMDAGQKGQRGIEW
>NZ_CP029197.1|WP_015032701.1|1677590_1679660_+|putative-cobaltochelatase
MNTRYPFTAVVGMDDLRLALLLNAVSPAVGGVLVRGEKGTAKSTAVRALAELLPAVPVVAGCRFSCDPASPDLGCPDGPHGTEPGVQRPARMVELPVGASEDRLVGSLDIEKALADGVKAFEPGLLAAAHRGILYVDEVNLLSDHLIDHLLDAAAMGSSYVEREGVSVRHAARFLLVGTMNPEEGELRPQLLDRFGLTVEVAASREPEQRVEVVRRRLAYEDDPGAFAARWADEETALRERIVTARELLPEVTLGDAVLLQIAATCAAFEVDGMRADIVMARTATALAAWAGRTEVTSEDVRQAALLALPHRRRRSPFDAPGLDEDKLDETLEQFKGQEPDEDPEPDGPGDGGPGDGGPGGGVPPQGDGPAAENAPAAEETSPPSPEPASEPAPASAPQGAGSGERAAVAAGEPFRTKVLSVPGLGEGAAGRRSRARTEHGRTTGSVRPRGALTKLHLAATVQAAAPHQKARGRTGPGLVVRRDDLRQATREGREGNLVLFVVDASGSMAARQRMSAVKGAVLSLLLDAYQRRDKVGLITFRGRDAEVALPPTSSVDAAAARLEKLPTGGRTPLSAGLLKAHDVLRVERLRDASRRPLLVVVTDGRATGGGADPVALAGRAARLHAAEGTASVVVDCETGPVRLGLARELARELGGTAVTLDELRADSIAGLVRDVRDVQAGQTTRRAA
>NZ_CP029197.1|WP_015032700.1|1676008_1677517_+|cobyric-acid-synthase
MRGGGLLVAGTTSDAGKSVVTAGICRWLVRQGIKVAPFKGQNMSLNSFVTREGAEIGRAQAMQAQAARVEPTALMNPVLLKPGSDRSSQVVLMGKPVGELSARGYHGGRQKELFEPVLACLEELRSTYDAVICEGAGSPAEINLRRTDIVNMGIARAARLPVVVVGDIDRGGVFAQFFGTTALLAPEDQELIAGYLVNKFRGDVTLLEPGLDMLHGLTGRRTFGVLPYAHGLGIDEEDGLRVSLRGAVRESVVAPPVGEDVLRVAVCAVPLMSNFTDVDALAAEPGVVVRFVDRAEELVDADLVVVPGTRGTVRALAWLRERGLADALVRRAAEGRPVLGVCGGFQVLGEHIEDEVESKAGAVDGLGLLPVRVRFAPGKTLARPVGEALGERVEGYEIHHGVADVRGGEPFLDGCRVGAVWGTHWHGSLESDGFRRAFLREVAAAAGRRFVPAPDTSFGALREEQLDRLGDLIEEHADTDALLRLIEQGPPKGLPFVPPGAP
>NZ_CP029197.1|WP_015032699.1|1675049_1676012_+|cobalamin-biosynthesis-protein
MPGRSRTTGVFAYGAAAGLAVDLLVGDPRRGHPVAAFGRAAAAVENRLHHDHRGWGALHTAVCAGTTVALGALAARAVRDRPAAAVALTAASVWAVVGGTTLGREARAIGGALAAGDLDVARERLPHLCGRDPHSLDGPAMARAVVESVAENTSDAVVGALFWGAVAGVPGLVGFRAVNTLDAMVGHKSPRHRRFGWASARLDDVAGWPGARLTAALATVAGGDPRGALKAWRADAARHPSPNAGPVEASFAGALGVRLGGTLSYGGRVEHRPVLNGEGRPVEVADIDRAVRLSRRVTGLTLAVCVGGRLIASALKRRNA
>NZ_CP029197.1|WP_015032697.1|1674525_1674747_+|hypothetical-protein
MKIDWAALGSVFGVSLVATVALVGLFTLGVIGLSKQERAAAQGGSAALARTGAYACFGLCLAAVAYGIYLIVV
>NZ_CP029197.1|WP_015032696.1|1673247_1674513_+|inorganic-phosphate-transporter
MEHITLLLAIVVVTALVFDFTNGFHDTANAMATTISTGALKPKTAVAMSAVLNLVGAFLSVEVAKTISGGIINEEGIRTEVIFAALVGAILWNLLTWLLGLPSSSSHALFGGLIGAAVMSAGWSAVNGPTIVTKVLIPAVAAPIVAGLAAMLATRLTYKLGAKTDEKHTAKGYRVGQIASAGLVSLAHGTNDAQKTMGIITLALITGGAIAPGSNPPLWVIVSAGVAIAAGTYLGGWRIIRTMGKGLTDLRPQQGFAAQTSAATVILASSHLGFSLSTTQSCSGAVMGAGLGRKGGVVRWSTATRMFVAWGLTLPAAGLVGAGAEFLTKQGPWGIAAVAVLLIAGSGVIWSLSRRKPVDHHNVTADDLDEPAGVVTTAIAAVTPPPAAGSVAAVTDEDLKTTIPAPVPTDPTAPPAPAAAV
>NZ_CP029197.1|WP_015032695.1|1671737_1672865_-|alpha/beta-fold-hydrolase
MRPATATAAAVTTLLGVGAAAIAAGRYASDVALRAPSGRPLPGDPRLTVHATGPERITLTRSLASLRPGTYGIEGPGLHAVVGPVLDRVPHTADTVVRRLERVEQGVLGPGSRVRLTPQLHIGTPISALGLAHEDVEMPGELGPLPAWLVAAPRTTWVIALHGLGTTREHPLNVVPFYNRRKIPVLLPAYRGDEGAPASPDGLAHLGDSEWRDVDAAIRYAVHRGAAKVVLHGWGTGASMALRAAAESGVRDRISGLVLDSPVLDWEATLRNLAAARHVPAPLLPLAVRAAQGRTGPHGDLLDAASAPDALRVPALLFHGPDDTLAPWEPSVELAARRPDLVNLQVVRNAPHAAMWNADPVRYEEALRRFLTPLL
>NZ_CP029197.1|WP_086024630.1|1670199_1671609_-|hypothetical-protein
MARNSRLRLVRPRALATARRAVTTRRTRPAPRPPEGTPPRAELARQARHVLADAVRIARWAAVERGAETALRTGPGAAPAHERAAAALDLTPEQIRAGWDRARLAGLVELHGDTARPGWRLHAWDRDDSAVLRGWVALFDAWSLVHPAAEGVEPSAVAEVVEAVPQVLSLLQLSQGPVLVPALLDLLGQRVEELREERCEVPVTGPAPETPGAPAGAAPGAADAADGLPALLDWALEGLAAVGALTLDRGPEGRHATLTPLGNWAVWVKLEQICVAAQSPAGNIEQSAEDMLRGCARLTPGPARAEYRAWLAARTLSSAVAELLAVARGEDALLRGLAFEALRVVGAPAEAEVRATVAEPSLRPYALLWLAEYEGADPDDAQEVLTREESTWLWVDTAAAVADHGESALLVRHLESAVQGTVPALLDEVRAVGHPRTVQVLVALAAAHPDPALAKAVRRAAFQVHTGGA
>NZ_CP029197.1|WP_015032706.1|1684250_1685249_-|hypothetical-protein
MNSNTFGLPVRRTAAAATVAALTVGPVLLAAPAAHATGGEGRATAVVLRTGLDVSLLDKTVDVPLRVSLNEVRAPRTESETALSVKVQGAEGNKPIDILAADVATSKATVDEAKAEGYVNLVKARVHVPGIPLLSLIEVEKVTSKALCETGKKPVAESNVLGHVTVFGKKTTLSTGGRTQVTVPGVGKVTLDLSRTSTTSRTAAATALELAVEVDPLKLGVAEVNGTVTLAQATCETPKGPAPTQKPTEKPTQPPTQEPSERPSEQPTQQPTAKPSDAGGIKTNNGGTTPTQNLAETGGSSTTPYIAGGALALLVAGGGALALTRSRARSRG
>NZ_CP029197.1|WP_015032707.1|1685560_1686280_-|siderophore-interacting-protein
MGHGWQGAVLKLMRGKDFTFTVTGAEQVTEDYRRVRFTDGGLLAAAGIHPTMWVRLWFENAGKPHQRAYTLVDPDLEAGTFSLEFALHDGVASHWARGCAPGDTVEATLQGTGFEAPAPLPGRLLVVGDPASLPAVNSLLDALPGVPATVWFETQHASDEELPIRLDPEHHELRRVPRRNDGADLVARVKAELPGLADSDPYVWIACDTATTRTLATYARKELALPKERVHALGYWRAS
>NZ_CP029197.1|WP_015032708.1|1686371_1688513_+|penicillin-acylase-family-protein
MDGIGVSVSIEVYRDAWGVPHLRAADPDELAFAQGRVTAHDRAWQLEVERHRAQGTTAAFLGAAEVAWDTFARRSRLADTARRCFERLERDDPDTAAWVRAYVAGVNDGLPEGAGRAPEFAETGLTPGRWEPWTPLAVWLTTHILFAGFPTKLWREEVARRLGEEWTELFATDGPGTSGSNGWLVAGERTASGAALIAGDPHRFIEAPGVYQQIRLACPSYDVVGIAVPGIPGLAHFGHTGPVAWAITNAMSDYQDLYRERLRRLPDGGIEAYGPEGHRPATAHRETIEVAGGNPVVIEVVETDRGPVIIGLDDEPAGEAPEDAPWEAVSLRYPPRVTGELGFGVLPALLRARTVADVDTALDGWIEPVNVVLAADTRGGLLHRVAGHVPVRHRTNSLRIVPAWDPAHAWQDAPAPLPRAEVDGHAVMANARGLAAPLGIEFAPPHRAARIDALLGASAEWTPEAMTAVHRDTDNPSAARLLAAVDRAGAPGPDGAGSPAALSPAASAVRERLLGWDRRMDADSVDAGLYAAVRGAVVRRLAAHEAFAALREPAPYPEVFRPWLALGPRVAYALETLLVAGPVPAGDVDRIVREALDEVGAGEPPAAWGVTHRLAPWQALPDPDDAKWPGLGGDHDCVLSTSSVPGWTDRSARASAARYVWDLADRERSGWIVPFGASGVPGDPHRDDQLPLWLRGELAPVTTDWQNLTKEQG
>NZ_CP029197.1|WP_015032709.1|1688509_1689079_+|acetyltransferase
MTTATAAYVHRIEGFGTVTVRPVEPERDAPLLHAWVNEERSRFWGMVGTTVEQVRDVYAHLDSLTTHHGFLVSLDGEPVALLQTYDPEADRVSECYEVEPGDVGAHFLVAPNPAPRPGFTGMLLTALIAFALKDRTRLVVEPDAANEKAIARMVRAGFELGPEVVLPEVDLPEVFIPEKKARLAFLTRR
>NZ_CP029197.1|WP_015032710.1|1689232_1690318_-|amidohydrolase-family-protein
MSDHAVLHVKGRVLVGPEDVRDELWCVDGRITFDRPAAEAVTVEGWVLPGLVDAHCHVGLDRHGPVDAATSEKQALTDRDAGTLLIRDAGSPSDTRWIDEREDLPKIIRAGRHIARTRRYIRNYAHEIEPADLVAYVGREARRGDGWVKLVGDWIDREAGDLTACWPRPEVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTEDTIPLFAERGVAIVPTLVNIATFPHLADGGEEKFPRWSAHMRRLHERRYDTVRAAFDAGVPVFVGTDAGGSLAHGLVAEEVEELTKAGIPPLDALAATAWRARAWLGRPSLEEGAPADLVVYGEDPRADVRVLAAPRRVVVNGRVIG
>NZ_CP029197.1|WP_041663715.1|1690423_1691527_+|alanine--glyoxylate-aminotransferase-family-protein
MTHPLLDLAPLTAAHFASIERRVAALLSTEQDVVITQGEALLPLEGCIRSGARAGSTALNVVTGPYGQTFGNWLRDCGATVVDLEVPFHTAVTAAQVEQALAAHPEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDMCIIGAQKAMGGPAGVSAVSVSARAWERFAANPAAPRRSYLSLLDWKERWIDGGRKALLHAPAQLEMLALEACVERIEAEGLDALMARHASAAAATRAGALALGGGLEPFVYEAKDAAPVATTLRVPAGVDASALVAKALAADPSLPLIAGGGALAGEMIRVNHYGVDATPGAVQSSLAALGAALGEAGRAVDLEGARRAVTEAWAV
>NZ_CP029197.1|WP_041662218.1|1691633_1692701_-|alkene-reductase
MTTAFDPVDLAGTRLSNRIAMAPMTRSRADAVRRTPTALVAEYYAQRASAGLIISEGVHPVAEGQGYPFTPGIHSREQIAAWREVTDAVHERGGRIFAQLMHSGRIGHPDLLDGDLHPVGPSAVAPAGQAFTPEGPKDYVTPRVLTGDEVRETVAGFAAAARHAVEAGFDGVEIHGANGYLIQQFLATGSNHRTDEWGGPVENRIRFAVEVVRAVAAEIGPERTGLRISPANTLNDIAETETEELYTALLDAIEPVGIAYLHVLETAPELRPLVLDLRKRFAGTFILNPSTEGPTSSESLALIEDGTTDLVAFGRLFIANPDLPARLRADGPYNEPDGATMYGGDHRGYVDYPAL
>NZ_CP029197.1|WP_015032713.1|1692813_1693323_+|winged-helix-turn-helix-transcriptional-regulator
MPANDPACTDTTPSAARGGPVGIALARVARMHRLAAGRRLRELDLYPGQEMMMMRLWDCGPVRQSELIQSLGLDASTVTKMLQRLEQCGHVRRGPDPADRRAVLVEATEEGRSLRAGVEGVWSDLEKVSLNGLDPADRAELARLLGLVADNLRAEAGESGDCPPPPRGC
>NZ_CP029197.1|WP_015032714.1|1693441_1694500_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MDSLEEPLGGAEFAPEHTYLNTSACALLPRRTIEAVVLLAEETAAGRPDGAGDFAVVDEARATYARLMGVTPERVAVGSSVAVHCGMIAQSMPAGAEILFPEGDFSSVITPFTIRGDLKVRFAPLDRLAESVGPDTALVAFSAVQSADGRTADFAAIRAAAAAHGARTLLDATQSAGWLPLRAGEWDYTVAGGYKFLLCPRGASFLTVTEEAQDSLLAIHANWVTGEERWVNSYGPVRELARSARRFDEPPAFLSYHGAARSLALLEEIGIERIEAHVKGLAARFRAGLVALGHAPVMDESAVVAVPGLGDREDALREADVLLSARAGNLRASFHLYNTAADVDRALAALKA
>NZ_CP029197.1|WP_015032715.1|1694626_1695334_-|DsbA-family-oxidoreductase
MRVEIWSDIACPWCYIGKARFEKGLAAFAHRDDVEVVHRSFELDPNRAKGDTGPVLEMLAKKYGRTLEEARAMEAHVASNAHAEGLGYRTEGRDHGNTFDIHRLLHLARDRGLQNELLDLAYRANFAEERSVFDPETLVTLGVEAGLDEAEVRAVLADDSAYAEAVREDEREAAELGANGVPFFVLDRRYGISGGQPAEVFTQALEQAWQGRVLQPVGGDAAVCDPDGSCEVPGA

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Crispr_ID: NZ_CP029197_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_6

1693281-1693360

Orphan

Consensus_repeat	Method
GGGCGAGTCGGGCGACTGCCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_6

>merge|NZ_CP029197|6|1693281-1693360|CRISPRCasFinder
GGGCGAGTCGGGCGACTGCCCGCCCCCGCCGCGCGGCTGCTAGGGCGTGACGGTCGGGGCGAGTCGGGCAACTGCCCGCC

>NZ_CP029197|6|6|1693281-1693360|CRISPRCasFinder
GGGCGAGTCGGGCGACTGCCCGCC	CCCGCCGCGCGGCTGCTAGGGCGTGACGGTCG
GGGCGAGTCGGGCAACTGCCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015032723.1\|1702856_1703357_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380345
NZ_CP029197.1\|WP_015032707.1\|1685560_1686280_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP029197.1\|WP_015032720.1\|1699399_1700407_+\|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|176229
NZ_CP029197.1\|WP_015032717.1\|1695881_1696907_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP029197.1\|WP_078508625.1\|1682435_1684082_+\|threonine-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|236128
NZ_CP029197.1\|WP_015032718.1\|1696977_1698360_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP029197.1\|WP_015032706.1\|1684250_1685249_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|282710
NZ_CP029197.1\|WP_015032710.1\|1689232_1690318_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|238624
NZ_CP029197.1\|WP_015032716.1\|1695398_1695875_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP029197.1\|WP_041663712.1\|1681664_1682393_-\|ZIP-family-metal-transporter	unknown	unknown	gnl\|CDD\|223505
NZ_CP029197.1\|WP_041663715.1\|1690423_1691527_+\|alanine--glyoxylate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223153
NZ_CP029197.1\|WP_015032703.1\|1680261_1681662_+\|cobyrinate-a,c-diamide-synthase	unknown	unknown	gnl\|CDD\|234896
NZ_CP029197.1\|WP_041662218.1\|1691633_1692701_-\|alkene-reductase	unknown	unknown	gnl\|CDD\|239243
NZ_CP029197.1\|WP_015032708.1\|1686371_1688513_+\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP029197.1\|WP_015032709.1\|1688509_1689079_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|379237
NZ_CP029197.1\|WP_041662219.1\|1698393_1699308_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378976
NZ_CP029197.1\|WP_041662221.1\|1702073_1702844_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP029197.1\|WP_015032715.1\|1694626_1695334_-\|DsbA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|239322
NZ_CP029197.1\|WP_041663718.1\|1700412_1701924_-\|aldehyde-dehydrogenase-(NADP(+))	unknown	unknown	gnl\|CDD\|143447
NZ_CP029197.1\|WP_015032714.1\|1693441_1694500_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|223594

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015032723.1\|1702856_1703357_-\|cupin-domain-containing-protein	gnl\|CDD\|380345	cd02215, cupin_QDO_N_C, quercetinase, N- and C-terminal cupin domains. This family contains quercetinase (also known as quercetin 2,3-dioxygenase, 2,3QD, QDO and YxaG; EC 1.13.11.24), a mononuclear copper-dependent dioxygenase that catalyzes the cleavage of the flavonol quercetin (5,7,3',4'-tetrahydroxyflavonol) heterocyclic ring to produce 2-protocatechuoyl-phloroglucinol carboxylic acid and carbon monoxide. Bacillus subtilis quercetin 2,3-dioxygenase (QDO) is a homodimer that shows oxygenase activity with several divalent metals such as Mn2+, Co2+, Fe2+, and Cu2+, although the preferred one appears to be Mn2+. The dioxygen binds to the metal ion of the Cu-QDO-quercetin complex, yielding a Cu2+-superoxo quercetin radical intermediate, which then forms a Cu2+-alkylperoxo complex which then evolves into endoperoxide intermediate that decomposes to the product. Quercetinase is a bicupin with two tandem cupin beta-barrel domains, both of which are included in this alignment model. The pirins, which also belong to the cupin domain family, have been shown to catalyze a reaction involving quercetin and may have a function similar to that of quercetinase.	2.40982e-20
NZ_CP029197.1\|WP_015032707.1\|1685560_1686280_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	2.19617e-52
NZ_CP029197.1\|WP_015032720.1\|1699399_1700407_+\|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl\|CDD\|176229	cd08268, MDR2, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.77764e-135
NZ_CP029197.1\|WP_015032717.1\|1695881_1696907_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	2.34482e-102
NZ_CP029197.1\|WP_078508625.1\|1682435_1684082_+\|threonine-phosphate-decarboxylase	gnl\|CDD\|236128	PRK07908, PRK07908, threonine-phosphate decarboxylase.	4.26211e-151
NZ_CP029197.1\|WP_015032718.1\|1696977_1698360_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.40872e-55
NZ_CP029197.1\|WP_015032706.1\|1684250_1685249_-\|hypothetical-protein	gnl\|CDD\|282710	pfam04886, PT, PT repeat. This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.	0.00167795
NZ_CP029197.1\|WP_015032710.1\|1689232_1690318_-\|amidohydrolase-family-protein	gnl\|CDD\|238624	cd01299, Met_dep_hydrolase_A, Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	4.26029e-63
NZ_CP029197.1\|WP_015032716.1\|1695398_1695875_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.26859e-10
NZ_CP029197.1\|WP_041663712.1\|1681664_1682393_-\|ZIP-family-metal-transporter	gnl\|CDD\|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	1.43838e-11
NZ_CP029197.1\|WP_041663715.1\|1690423_1691527_+\|alanine--glyoxylate-aminotransferase-family-protein	gnl\|CDD\|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	8.63143e-81
NZ_CP029197.1\|WP_015032703.1\|1680261_1681662_+\|cobyrinate-a,c-diamide-synthase	gnl\|CDD\|234896	PRK01077, PRK01077, cobyrinate a,c-diamide synthase.	0
NZ_CP029197.1\|WP_041662218.1\|1691633_1692701_-\|alkene-reductase	gnl\|CDD\|239243	cd02933, OYE_like_FMN, Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Members of OYE family include 12-oxophytodienoate reductase, pentaerythritol tetranitrate reductase, morphinone reductase, and related enzymes.	1.89503e-178
NZ_CP029197.1\|WP_015032708.1\|1686371_1688513_+\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	4.3221e-159
NZ_CP029197.1\|WP_015032709.1\|1688509_1689079_+\|acetyltransferase	gnl\|CDD\|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.90839e-55
NZ_CP029197.1\|WP_041662219.1\|1698393_1699308_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|378976	pfam12852, Cupin_6, Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.	5.2923e-52
NZ_CP029197.1\|WP_041662221.1\|1702073_1702844_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.42893e-62
NZ_CP029197.1\|WP_015032715.1\|1694626_1695334_-\|DsbA-family-oxidoreductase	gnl\|CDD\|239322	cd03024, DsbA_FrnE, DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins.	7.22738e-85
NZ_CP029197.1\|WP_041663718.1\|1700412_1701924_-\|aldehyde-dehydrogenase-(NADP(+))	gnl\|CDD\|143447	cd07129, ALDH_KGSADH, Alpha-Ketoglutaric Semialdehyde Dehydrogenase. Alpha-Ketoglutaric Semialdehyde (KGSA) Dehydrogenase (KGSADH, EC 1.2.1.26) catalyzes the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. This CD contains such sequences as those seen in Azospirillum brasilense, KGSADH-II (D-glucarate/D-galactarate-inducible) and KGSADH-III (hydroxy-L-proline-inducible). Both show similar high substrate specificity for KGSA and different coenzyme specificity; KGSADH-II is NAD+-dependent and KGSADH-III is NADP+-dependent. Also included in this CD is the NADP(+)-dependent aldehyde dehydrogenase from Vibrio harveyi which catalyzes the oxidation of long-chain aliphatic aldehydes to acids.	0
NZ_CP029197.1\|WP_015032714.1\|1693441_1694500_-\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	1.25339e-38

>NZ_CP029197.1|WP_041662218.1|1691633_1692701_-|alkene-reductase
MTTAFDPVDLAGTRLSNRIAMAPMTRSRADAVRRTPTALVAEYYAQRASAGLIISEGVHPVAEGQGYPFTPGIHSREQIAAWREVTDAVHERGGRIFAQLMHSGRIGHPDLLDGDLHPVGPSAVAPAGQAFTPEGPKDYVTPRVLTGDEVRETVAGFAAAARHAVEAGFDGVEIHGANGYLIQQFLATGSNHRTDEWGGPVENRIRFAVEVVRAVAAEIGPERTGLRISPANTLNDIAETETEELYTALLDAIEPVGIAYLHVLETAPELRPLVLDLRKRFAGTFILNPSTEGPTSSESLALIEDGTTDLVAFGRLFIANPDLPARLRADGPYNEPDGATMYGGDHRGYVDYPAL
>NZ_CP029197.1|WP_041663715.1|1690423_1691527_+|alanine--glyoxylate-aminotransferase-family-protein
MTHPLLDLAPLTAAHFASIERRVAALLSTEQDVVITQGEALLPLEGCIRSGARAGSTALNVVTGPYGQTFGNWLRDCGATVVDLEVPFHTAVTAAQVEQALAAHPEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDMCIIGAQKAMGGPAGVSAVSVSARAWERFAANPAAPRRSYLSLLDWKERWIDGGRKALLHAPAQLEMLALEACVERIEAEGLDALMARHASAAAATRAGALALGGGLEPFVYEAKDAAPVATTLRVPAGVDASALVAKALAADPSLPLIAGGGALAGEMIRVNHYGVDATPGAVQSSLAALGAALGEAGRAVDLEGARRAVTEAWAV
>NZ_CP029197.1|WP_015032710.1|1689232_1690318_-|amidohydrolase-family-protein
MSDHAVLHVKGRVLVGPEDVRDELWCVDGRITFDRPAAEAVTVEGWVLPGLVDAHCHVGLDRHGPVDAATSEKQALTDRDAGTLLIRDAGSPSDTRWIDEREDLPKIIRAGRHIARTRRYIRNYAHEIEPADLVAYVGREARRGDGWVKLVGDWIDREAGDLTACWPRPEVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTEDTIPLFAERGVAIVPTLVNIATFPHLADGGEEKFPRWSAHMRRLHERRYDTVRAAFDAGVPVFVGTDAGGSLAHGLVAEEVEELTKAGIPPLDALAATAWRARAWLGRPSLEEGAPADLVVYGEDPRADVRVLAAPRRVVVNGRVIG
>NZ_CP029197.1|WP_015032709.1|1688509_1689079_+|acetyltransferase
MTTATAAYVHRIEGFGTVTVRPVEPERDAPLLHAWVNEERSRFWGMVGTTVEQVRDVYAHLDSLTTHHGFLVSLDGEPVALLQTYDPEADRVSECYEVEPGDVGAHFLVAPNPAPRPGFTGMLLTALIAFALKDRTRLVVEPDAANEKAIARMVRAGFELGPEVVLPEVDLPEVFIPEKKARLAFLTRR
>NZ_CP029197.1|WP_015032708.1|1686371_1688513_+|penicillin-acylase-family-protein
MDGIGVSVSIEVYRDAWGVPHLRAADPDELAFAQGRVTAHDRAWQLEVERHRAQGTTAAFLGAAEVAWDTFARRSRLADTARRCFERLERDDPDTAAWVRAYVAGVNDGLPEGAGRAPEFAETGLTPGRWEPWTPLAVWLTTHILFAGFPTKLWREEVARRLGEEWTELFATDGPGTSGSNGWLVAGERTASGAALIAGDPHRFIEAPGVYQQIRLACPSYDVVGIAVPGIPGLAHFGHTGPVAWAITNAMSDYQDLYRERLRRLPDGGIEAYGPEGHRPATAHRETIEVAGGNPVVIEVVETDRGPVIIGLDDEPAGEAPEDAPWEAVSLRYPPRVTGELGFGVLPALLRARTVADVDTALDGWIEPVNVVLAADTRGGLLHRVAGHVPVRHRTNSLRIVPAWDPAHAWQDAPAPLPRAEVDGHAVMANARGLAAPLGIEFAPPHRAARIDALLGASAEWTPEAMTAVHRDTDNPSAARLLAAVDRAGAPGPDGAGSPAALSPAASAVRERLLGWDRRMDADSVDAGLYAAVRGAVVRRLAAHEAFAALREPAPYPEVFRPWLALGPRVAYALETLLVAGPVPAGDVDRIVREALDEVGAGEPPAAWGVTHRLAPWQALPDPDDAKWPGLGGDHDCVLSTSSVPGWTDRSARASAARYVWDLADRERSGWIVPFGASGVPGDPHRDDQLPLWLRGELAPVTTDWQNLTKEQG
>NZ_CP029197.1|WP_015032707.1|1685560_1686280_-|siderophore-interacting-protein
MGHGWQGAVLKLMRGKDFTFTVTGAEQVTEDYRRVRFTDGGLLAAAGIHPTMWVRLWFENAGKPHQRAYTLVDPDLEAGTFSLEFALHDGVASHWARGCAPGDTVEATLQGTGFEAPAPLPGRLLVVGDPASLPAVNSLLDALPGVPATVWFETQHASDEELPIRLDPEHHELRRVPRRNDGADLVARVKAELPGLADSDPYVWIACDTATTRTLATYARKELALPKERVHALGYWRAS
>NZ_CP029197.1|WP_015032706.1|1684250_1685249_-|hypothetical-protein
MNSNTFGLPVRRTAAAATVAALTVGPVLLAAPAAHATGGEGRATAVVLRTGLDVSLLDKTVDVPLRVSLNEVRAPRTESETALSVKVQGAEGNKPIDILAADVATSKATVDEAKAEGYVNLVKARVHVPGIPLLSLIEVEKVTSKALCETGKKPVAESNVLGHVTVFGKKTTLSTGGRTQVTVPGVGKVTLDLSRTSTTSRTAAATALELAVEVDPLKLGVAEVNGTVTLAQATCETPKGPAPTQKPTEKPTQPPTQEPSERPSEQPTQQPTAKPSDAGGIKTNNGGTTPTQNLAETGGSSTTPYIAGGALALLVAGGGALALTRSRARSRG
>NZ_CP029197.1|WP_078508625.1|1682435_1684082_+|threonine-phosphate-decarboxylase
MGVRSGAPVDEVLALVDGVLREAGLGRAGVRSLGTLDARAAEPGLVAAAAVLGVPLRGFTAGELAAVPVPHPSELPLAATGTASVAEAAALLAAAGDGPGAGAGVGAGGDGTGAAAGVGATGDGPGAAAGVGAGGGAVLLVPKRKSARVTCALAASVPVRTNEDAPAVRLLHLPHGYIAGEPGSPPTIPTPHTTAAMDMHTHTDAHDLRHHGDAEVRDEKLIDLAVNVRTNTPPEWLRERIAASLTGLAAYPDGRSARAAVAERHDLPSNRVLLTAGAAEAFVLLARALPVRRPVVVHPQFTEPEAALRDAGHEVGRVLLREEDGFRLDPASVPQDADLVVIGNPTNPTSVLHPAATIAALARPGRTLVVDEAFMDAVPGERESLAGRTDVPGLVVLRSLTKTWGLAGLRIGYVLAEPETIVALERTQPLWPVSTPALVAAEACMSRVALAEAEHAAHRIGVERAHLLAGLAEFDEVRTVAGSEGPFVLLRIDGADAVRERLRSLGFAARRGDTFPGLDRNWLRIAVRDRVTTNRFLQALDQALLMGG
>NZ_CP029197.1|WP_041663712.1|1681664_1682393_-|ZIP-family-metal-transporter
MAVVVALGAFLMTLFGGWVAQRVTDRRHLVLGLAGGLMLGVVGLDLLPEALEAAGDEVFGVPEALLLFVGGFLLAHAVERLLAVRRAAHGVAADERVPQVGMTAAAAMVGHSLMDGIALGAAFQVGGGMGATVALAVITHDFADGFNTYTITSLYGNARRKALTMLVADALAPLVGAASTLLFTLPEELLGGYLGFFGGALLYLAAAEILPEAHHDHPARSTLLCTVGGVGFIWLVVGVSGG
>NZ_CP029197.1|WP_015032703.1|1680261_1681662_+|cobyrinate-a,c-diamide-synthase
MVARLVIAAPSSGAGKTTVATGLMAAFAGRGLAVSPHKVGPDYIDPGYHALATGRPGRNLDAYMCGTGLIAPLFEHGARGCDLAVVEGVMGLYDGAADQGELASTAQVSKLLKAPVVLVVDASSQSRSVAALVHGFASWDPEVRIGGVILNKVATDRHEHLLREALGESGVPVLGVLRRAPAVATPSRHLGLVPVAERQAAAVAAVAAQAEQVLAGCDMEALLALARSAPELHAEPWVPHGSGAGVPQGGTGGHSPAPGPRTADRSGRRPVVAVAGGAAFTFSYAEHTELLRAAGADVVTFDPLRDEALPEGTSGLVIGGGFPEMYGEQLSANEPLRKAVAELARSGAPVAAECAGLLYLARSLDGHPMCGVLDADARMSERLTLGYRDAVAVSDSVLAPAGARMRGHEFHRTVVEPGAGATAAWGLRQPERRVEGFVQGGVHASYVHTHWAGAPEVAARFVEHCA
>NZ_CP029197.1|WP_015032714.1|1693441_1694500_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MDSLEEPLGGAEFAPEHTYLNTSACALLPRRTIEAVVLLAEETAAGRPDGAGDFAVVDEARATYARLMGVTPERVAVGSSVAVHCGMIAQSMPAGAEILFPEGDFSSVITPFTIRGDLKVRFAPLDRLAESVGPDTALVAFSAVQSADGRTADFAAIRAAAAAHGARTLLDATQSAGWLPLRAGEWDYTVAGGYKFLLCPRGASFLTVTEEAQDSLLAIHANWVTGEERWVNSYGPVRELARSARRFDEPPAFLSYHGAARSLALLEEIGIERIEAHVKGLAARFRAGLVALGHAPVMDESAVVAVPGLGDREDALREADVLLSARAGNLRASFHLYNTAADVDRALAALKA
>NZ_CP029197.1|WP_015032715.1|1694626_1695334_-|DsbA-family-oxidoreductase
MRVEIWSDIACPWCYIGKARFEKGLAAFAHRDDVEVVHRSFELDPNRAKGDTGPVLEMLAKKYGRTLEEARAMEAHVASNAHAEGLGYRTEGRDHGNTFDIHRLLHLARDRGLQNELLDLAYRANFAEERSVFDPETLVTLGVEAGLDEAEVRAVLADDSAYAEAVREDEREAAELGANGVPFFVLDRRYGISGGQPAEVFTQALEQAWQGRVLQPVGGDAAVCDPDGSCEVPGA
>NZ_CP029197.1|WP_015032716.1|1695398_1695875_-|GNAT-family-N-acetyltransferase
MIRLATAADLDAVVALHTEARATYYRGHLPDADFLGPEEIARSRAGWAAAVDRGAVLCAVRDGEIAGIAAYGEREGLMHLTQLHVLPARWRAGIGAELHAACVEKWRAAGVTTVRLDVFDKNERAQAFYTAQGWTPDPQTPRHGDHLVLRLTLAAETE
>NZ_CP029197.1|WP_015032717.1|1695881_1696907_-|helix-turn-helix-domain-containing-protein
MPVESRVRRVAVIAAPPVSMFNLAIPEMLFGKVEIDGAPGYETVICAPDPGPVPTTGGLDLVVPHGLDAVAGADTVVLAGSGSYTDPDRRILDALRGAAAAGSRIASICTGAFALAEAGLLDGRAATTYWAYSSLLAARHPTVDLQDDVLFVQDGPVLTSSGYAAGIDLCLHVIRTDFGAAVANTVARLALVAPVRPGGQTQFTQTPLPPERGASFADTRAWAMEHLDEPLGLTDLARHAGVSVRTLSRRFHAETGVSPLQWLLHQRVERAKELLETTSLAMDGVARASGLGTADSLRQHLLRRTGLTPSAYRSSFSRLTTPAPTPTPARTPATVPAPRAS
>NZ_CP029197.1|WP_015032718.1|1696977_1698360_+|MFS-transporter
MTSTELARASVVPAAPPAAPSRSPGPALAAAMLGFALITLDTSVVNVALPAIGADLGAGMSGLQWVVDAYTLVFAALLLSSGALADRVGASRAYGWGAVVFVLASAACGLAPGLPALLAARTVQGAAAAVMLPASLALVREAYGDPGRRARAVSLWAAGGTLAVALGPVAGGALTTAWSWRGVFFVNLPLGLVALALLGRVARSARRPAPLDLPGQLTAMTALGALTFAAIEGGTEGWWALGLAVVSFAAFLVVEARRRHPVVPLGLFRNPTVAVAVAAGSANSVAFYGMLFVFSLFFQQVLGLSALGAGLMFLPMTGLLAGVNILSARAAARYGARLPIVVGQAVAVAGLLGLLTVDADTSRPLQALLLVPLALGAGFSLPPLIASMMEAVPAERAGTAAGLLNAVRQTAGALAIAVFGSLAAASVEAALRTGLLVSAALLALTTLLSLRLPGRLPGRA
>NZ_CP029197.1|WP_041662219.1|1698393_1699308_-|AraC-family-transcriptional-regulator
MDVLSDAIAAMRTGRPHSSRTVRFAPWGIRFPPGKGAGFHVVLQGTAWLLPPDDAAPVRLGPGDVVLLAHGTGHGLADHPGTPLVDALPAPDGSWPTPPDRGPIGADETLLLCGAYQLSRARAHPLLTDLPPFVHLPARVGAHPRLRAAVDLLGAELAEPQPGSDAIVPALLDTLLLYLLRTWWLTERPDRSTGWSAALADPAVAGALRALHGDPAHAWTVEELGALTGLSRAAFARRFTTLVGRAPLAYLTWWRMTTAGRLLRTDDLPLRAVAQRSGYSSEFAFAKAFKRAYGVAPGQYRKGA
>NZ_CP029197.1|WP_015032720.1|1699399_1700407_+|zinc-dependent-alcohol-dehydrogenase-family-protein
MTTTGMTTKAVLFHELGGPEVLTVEEVPLPAPGPGEVLVRVEAIGLNRAEALFRAGTYYYPATLPGSRLGYEAAGVVEAVGAGVTAYAPGDPVMAAANFDFGVHGVYAERVVLPQEYVVARPEGVDAVTAAAVWLSYFTAYGGMVLTGGLGAGEHVVITGASSSVGTAALQVALRVGAVPIATTRTEAKRKRLLELGAAHVVVTDTEDLVGEVRRITCGAGADLAFDAIGGPGFARLGDALRTGGTAVLYGWLDPRPTELSRNWPLTTHTYANGELARSEEGRRRAAGFIGSGLRDGSLAPVIAETFDGLERIADAHRLMESNAHLGKIVVRVPS
>NZ_CP029197.1|WP_041663718.1|1700412_1701924_-|aldehyde-dehydrogenase-(NADP(+))
MAAEPVWSVDPRTGKPRERVGTESTAADVDRAVRAAHQVREALADRTVRAAFLRTAADLLDGAGERIVGTADAETALGPVRLTGELARTTAQLRAFAEVVEEGSFLDVRIDLPDPGATPPRPDMRRWKIPLGVVAVYAASNFPLAFSVPGGDTASALAAGCPVVVKGHPDHPATSELCASLLRGAAAKTGLPEDVVVLVHGFDAGVELVRHPLVAAAGFTGSVRGGRALFDAAAARPVPIPFHGELGSLNPVVLTPAAVEERAEEIGAGLAGSMTLGAGQFCTKPGFVLAPTGEAGDRFLDALAAGVSAAAPAVLLDHRMREAFVAGAAERAALAGVAAPVTPGPGGTHTVSAGVLAVDAARLTGGPDGEGHDLLLEECFGPVTVVARYDSRTEISEVLSRLPGNLTATLHIAERGEDADAASLLAELTPLAGRVLVNGWPTGVAVAAAQHHGGPYPATTSTSTSVGATAIERWLRPVTYQSTPGHLLPPELRDGNPLGVPRR
>NZ_CP029197.1|WP_041662221.1|1702073_1702844_+|IclR-family-transcriptional-regulator
MATADAGGAQVKSAVRTVELLEYFAGRPGMHSLAAVQEAVGYPKSSLYMLLRTLVELGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAASRPTLDRLSDDTTETIHLARLDGTNVVYLATRQSQHYLRPFTRVGRRLPAHSTSLGKALLATHTDDQVRKLLPETLPALTEHTITDREQLIEELHAIREQGISVDREENTLGLRCFGVAIPYRTPARDAISCSVPVARLTPAHEQMIKDALFDARDRLTLATRRL
>NZ_CP029197.1|WP_015032723.1|1702856_1703357_-|cupin-domain-containing-protein
MNDNNAPFAPLLTRAADAETTADPSSVMTLLADSGTTGGQLTSYRSTFAEGAVGAPAHFHTKASEMFYVIDGSLQVLVGEELSVLEKGDFLLVPPHTAHAFAAAPGAEADVLFVFTPGMARFDYLRLLGRVMRGEASFEEIKASSEQYDNHYVDSPAWQKALAERG

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Crispr_ID: NZ_CP029197_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_7

1866550-1866641

Orphan

Consensus_repeat	Method
TCACAGCCGTTCGACGACCGTGACGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_7

>merge|NZ_CP029197|7|1866550-1866641|CRISPRCasFinder
TCACAGCCGTTCGACGACCGTGACGTCCGCCTGACCGCCGCCCCCGCACACGGGCCCCTCCCCCACTCACAGCCGTTCGATGACCGTGACGT

>NZ_CP029197|7|7|1866550-1866641|CRISPRCasFinder
TCACAGCCGTTCGACGACCGTGACGT	CCGCCTGACCGCCGCCCCCGCACACGGGCCCCTCCCCCAC
TCACAGCCGTTCGATGACCGTGACGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_041662250.1\|1873952_1874543_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP029197.1\|WP_071891236.1\|1864587_1866294_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223587
NZ_CP029197.1\|WP_015032870.1\|1868112_1868733_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP029197.1\|WP_041662249.1\|1872902_1873421_-\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|274679
NZ_CP029197.1\|WP_015032873.1\|1870730_1871876_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP029197.1\|WP_015032862.1\|1860323_1861073_+\|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|181174
NZ_CP029197.1\|WP_015032876.1\|1873518_1873908_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|380093
NZ_CP029197.1\|WP_015032878.1\|1874638_1875766_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
NZ_CP029197.1\|WP_015032865.1\|1862654_1863707_+\|2-nitropropane-dioxygenase	unknown	unknown	gnl\|CDD\|240081
NZ_CP029197.1\|WP_015032861.1\|1859466_1860258_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236116
NZ_CP029197.1\|WP_015032863.1\|1861069_1861927_+\|CoA-transferase-subunit-A	unknown	unknown	gnl\|CDD\|224702
NZ_CP029197.1\|WP_015032860.1\|1858589_1859465_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236099
NZ_CP029197.1\|WP_041662246.1\|1856465_1857983_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|170047
NZ_CP029197.1\|WP_015032859.1\|1857998_1858424_-\|ribonuclease	unknown	unknown	gnl\|CDD\|238340
NZ_CP029197.1\|WP_015032864.1\|1861923_1862655_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224968
NZ_CP029197.1\|WP_015032872.1\|1869536_1870673_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP029197.1\|WP_015032874.1\|1871875_1872895_+\|acyl-CoA/acyl-ACP-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP029197.1\|WP_015032866.1\|1863754_1864663_+\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NZ_CP029197.1\|WP_015032871.1\|1868748_1869540_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|236110
NZ_CP029197.1\|WP_015032869.1\|1866908_1868066_-\|acetyl-CoA-C-acetyltransferase	unknown	unknown	gnl\|CDD\|181123

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_041662250.1\|1873952_1874543_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	5.81948e-09
NZ_CP029197.1\|WP_071891236.1\|1864587_1866294_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.56258e-122
NZ_CP029197.1\|WP_015032870.1\|1868112_1868733_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	4.41262e-19
NZ_CP029197.1\|WP_041662249.1\|1872902_1873421_-\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	2.61873e-08
NZ_CP029197.1\|WP_015032873.1\|1870730_1871876_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.32404e-129
NZ_CP029197.1\|WP_015032862.1\|1860323_1861073_+\|enoyl-CoA-hydratase-family-protein	gnl\|CDD\|181174	PRK07938, PRK07938, enoyl-CoA hydratase family protein.	3.05667e-152
NZ_CP029197.1\|WP_015032876.1\|1873518_1873908_-\|VOC-family-protein	gnl\|CDD\|380093	pfam18029, Glyoxalase_6, Glyoxalase-like domain. This entry comprises a diverse set of domains related to the Glyoxalase domain. The exact specificity of these proteins is uncertain.	1.96756e-29
NZ_CP029197.1\|WP_015032878.1\|1874638_1875766_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	3.9736e-40
NZ_CP029197.1\|WP_015032865.1\|1862654_1863707_+\|2-nitropropane-dioxygenase	gnl\|CDD\|240081	cd04730, NPD_like, 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase family that reduce a range of alternative electron acceptors. Most use FAD/FMN as a cofactor and NAD(P)H as electron donor. Some contain 4Fe-4S cluster to transfer electron from FAD to FMN.	1.71163e-82
NZ_CP029197.1\|WP_015032861.1\|1859466_1860258_-\|SDR-family-oxidoreductase	gnl\|CDD\|236116	PRK07856, PRK07856, SDR family oxidoreductase.	2.68348e-124
NZ_CP029197.1\|WP_015032863.1\|1861069_1861927_+\|CoA-transferase-subunit-A	gnl\|CDD\|224702	COG1788, AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism].	6.24484e-59
NZ_CP029197.1\|WP_015032860.1\|1858589_1859465_-\|SDR-family-oxidoreductase	gnl\|CDD\|236099	PRK07791, PRK07791, short chain dehydrogenase; Provisional.	8.22462e-146
NZ_CP029197.1\|WP_041662246.1\|1856465_1857983_+\|hypothetical-protein	gnl\|CDD\|170047	PRK09687, PRK09687, putative lyase; Provisional.	2.05701e-21
NZ_CP029197.1\|WP_015032859.1\|1857998_1858424_-\|ribonuclease	gnl\|CDD\|238340	cd00607, RNase_Sa, RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate specific endoribonuclease which belongs to the superfamily of microbial ribonucleases. Typical of this sub-family, the enzyme hydrolyses the phosphodiester bonds of RNA at the 3' oxygen end of guanosine residues to yield oligonucleotides with the guanosine-2',3'-cyclophosphate at the 3' end and the hydroxyl group at the 5' end. The terminal guanosine-2,3'-cyclophosphate is hydrolysed by guanyl RNAses to give guanosine-3'-phosphate.	1.54236e-43
NZ_CP029197.1\|WP_015032864.1\|1861923_1862655_+\|CoA-transferase	gnl\|CDD\|224968	COG2057, AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism].	9.76211e-32
NZ_CP029197.1\|WP_015032872.1\|1869536_1870673_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	4.55093e-139
NZ_CP029197.1\|WP_015032874.1\|1871875_1872895_+\|acyl-CoA/acyl-ACP-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.2255e-29
NZ_CP029197.1\|WP_015032866.1\|1863754_1864663_+\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	4.24679e-73
NZ_CP029197.1\|WP_015032871.1\|1868748_1869540_-\|SDR-family-oxidoreductase	gnl\|CDD\|236110	PRK07831, PRK07831, SDR family oxidoreductase.	3.81631e-162
NZ_CP029197.1\|WP_015032869.1\|1866908_1868066_-\|acetyl-CoA-C-acetyltransferase	gnl\|CDD\|181123	PRK07801, PRK07801, acetyl-CoA C-acetyltransferase.	0

>NZ_CP029197.1|WP_071891236.1|1864587_1866294_-|DEAD/DEAH-box-helicase
MTRSERPHKRSPRTAQAKSTSQPKASRGGRRPTAPPPPSEFTPPETVTPALPAVAAFADLDMPEGLLRTLGEQGVTEPFPIQAATLPNSLAGRDVLGRGRTGSGKTLAFGLALLARTAGRRAESGAPLALVLVPTRELAQQVTDALTPYAAALRLRITTVVGGMSISRQSSALRRGAEVLIATPGRLHDLIDRGDCRLDQVAVTVLDEADQMADMGFLPQVTKLLKQVEPGGQRLLFSATLDRNVDRLVKMFLDDPVVHSVDPSAGAVTTMEHHVLYVMDETDKKAVTLKIAARDGRTILFLDTKRSVDRLVKRLLANGVRASGLHGGRSQPQRNRTLDQFKSGQVTTLVATNVAARGIHVDDLDMVVNVDPPMDHKDYLHRGGRTARAGESGSVFTLVLPEQKRDMGRLMSHAGISPRTAQIKSSDEQLAELTGAREPSGVPVVIEIPQPTPPRKPAGTGGGAGSGSGGNRRRRRPATAGGSAATGTGSGRATGTATGRSTGSAGRAAGSTGGAGRATGGGRGAGSGTGGGRGAAAGAGRGGRQAAGTSRSRSASSSRNSRPRPSDT
>NZ_CP029197.1|WP_015032866.1|1863754_1864663_+|tyrosine-protein-phosphatase
MHLSRRALLTATGATALVAALPPEAIARTGPRSARATAIRQIPLQGAVNVRDLGGYLTYDGSRVRHGLAYRGDHLAKLTAADLTTLAGLGLRTVVDLRIPTEVGYDGADRLPAGVVPVARPVTDNGLFGRLLTAIGSRDPVRQEEMLGGGRAAAFMREVYRTFVTDAANRAAFAATLRDLADPRRGPLLLHCTSGKDRTGWTGWLLLTLLGVPDSLARQDYLASNTFRAAYDARVREGLKQGGLMQNPDLIIPLQEVRAEYLDTALEQLRSSYGSVFRYVSEGLGLEFRELLALRERLVPAA
>NZ_CP029197.1|WP_015032865.1|1862654_1863707_+|2-nitropropane-dioxygenase
METALTELVGVRHPIVQTGMGWVAGPRLVSATANAGALGVLASATMTVDELRAAVREVRSRTDRPFGVNLRADAGDARERVRIIVDEGVRVASFALAPSRDLIAELKDAGVVVIPSVGARRHAEKVAGWGADAVLVQGGEGGGHTGEVATSVLLPQVVDAVGIPVIAAGGFHDGRGLVAALAHGAAGIAMGTRFLLTSDSTVPEAVKARYLAATVKDVTVTTAVDGLPHRMLRTELVASLENAGRVRSLTRALHRANGFRRLSGLSWPAMIRDGLALRHGKDLSWSQVLLAANTPMLLRASMVEGRTDLGVMAAGQVAGVIDDLPSCEELITRIMAEAAQVLRALPRPET
>NZ_CP029197.1|WP_015032864.1|1861923_1862655_+|CoA-transferase
MTTEATTAVSRAEYCVIACAEAWRDNGEVLASPMGLIPSLGARLAKRTFSPGLLLTDGEALLVGPDGEPEGWLPYRRHLTMVTGGKRHVMMGASQIDRYGNQNISCIGDWERPARQLLGVRGAPVNTLNNPVSYWIPKHSTRVFVARVDMICGVGYDHAVGPYHRLPRVVTDLAVLDFETPDHAMRLVSVHPGVTVDEVRAATGFELVTDGDVPDTREPTAAELRLIREVIDPAGLRDREVRA
>NZ_CP029197.1|WP_015032863.1|1861069_1861927_+|CoA-transferase-subunit-A
MTDKTMTPEDVVGRLRSGMTIGIGGWGSRRKPMALVRALLRSEIGDLTVISYGGPDIGLLAAAGRIRRLVAPFVTLDSIPLEPHYRAARERGTLALTELDEAMFMWGLHAAANRLPFLPVRAGLGSDVMRVNPELRTVTSPYEDGEEFVAVPALRMDAALVHLNRADRLGNGQYLGPDPYFDDLFCEAADTAYVSCERLVDRFPPDTVPQTLVVSRHSVTGVVETPNGAHFTSCVPDHPRDEPFQKLYATTPWPEFAERFLSGKSEDDYQAAVRAWHTEREEQRT
>NZ_CP029197.1|WP_015032862.1|1860323_1861073_+|enoyl-CoA-hydratase-family-protein
MGVCTSRPAPGVALVTVDFPPVNALPVKGWYALADAVRAAGRDPEVRCVVLTAEGRGFNAGVDIKELQRDPGHTSLIGANSGCAEAFAAVYECEVPVVAAVAGHCLGGGIGLVGNADAIVAAEDAVFGLPELDRGALGAATHLARLVPQHLMRTLYFTSRTVTAAELHAHGSVWRVVPRPGLLDAALGLAGEIAAKDGSLLRLAKAALNGIDPVDVRRSYRFEQGFTFEANLSGVADRVRDTFGKEGSP
>NZ_CP029197.1|WP_015032861.1|1859466_1860258_-|SDR-family-oxidoreductase
MELDGRVVLVTGGTRGVGAGITRAFLRAGAHVAVCARRPPDTPVQAAGRTAAFHPVDLREPTAVQELLSTLAERYGRLDVLVNNAGGTPYRLLGESDAERHARVVELNLTAPLTVTLAAHPLLRAARGTVVMIGSVSGTRPSPGTAAYGAAKAGLENLARSMAVEWAPEIRVNTLVLGMVETEMSHLHYGDEAGIAAVGRTVPLGRLAAPDEIGEAAVFLASGRAAYVSGASLLVHGGGERPAFLDAANVNGTTTAPTADKES
>NZ_CP029197.1|WP_015032860.1|1858589_1859465_-|SDR-family-oxidoreductase
MGICEGRVVIVTGAGRGLGRAHALAFAAEGARVVVNDLGVGLDGRPGPESPAAAVVEEIRAAGGRAVAHGGDIATTEGAASLVTTALDAYGRLDTLVSNAGFLRDRMLVNLDEEDWDAVMRVHAKGHFLPLRHAAAHWRAEAKAGRAPDARIVHTTSGAGLLGSVGQGNYAAAKAAIIGLTLVAAAELARYGVQVNAIAPAARTRMTEQVFGGLDALPEDVSPLVVWLGSAASAGVTGRVFEAEGGRLTVMEGWRPGPTADKGTRRSPAEAGETARRLLAEATPPHPVYGA
>NZ_CP029197.1|WP_015032859.1|1857998_1858424_-|ribonuclease
MRIPPRFTLAGGVATALLSSLLLGAPATAAPAPAPTAVVTSVATNAAVGHICSSALPGEAHTTLRLIDAGGPFPYSQDGSVFQNRERVLPAHSLGYYHEYTVKTPGVPTRGARRIVTGASAQEDYYTADHYASFDLIDHGC
>NZ_CP029197.1|WP_041662246.1|1856465_1857983_+|hypothetical-protein
MSTLFDAIRDGDEDGAVRALRDGAGPEDVEDGETALYRAAVGNEAGIVRVLLAAGADPGRGSGEDGADLPLCGAAVGGHTEVVRALLAAGAEADQEEAFGFTALAWALRLGHADTARALLEYGADPDRRGPDGVLPLVAAARRGSTGCVRALLDHGADAREAALREARRWIGADIAAELRRGLVAGNEGGQTFEAVVRRVREDGGVTVVVELLREDGAPGRGDERQTGHAAIATLLESSLGLRTSHEELAARALRCGDPELDDWTTAVAELSGRADEETFVAAAAWCAYRDPLRRALGARVLGALPGFAPSAVPVLRRLAAEVVTSAPTREAASGRAAAGPAAREPVLSVVSALGECADPAAVPDLLAAAAHPDAAVRRAVAGSLAGIVPAGHAEALGVLLALSRDGDARVRDWATLALAELPDDTPLVREGLAERLGDADPETAAEAARGLAIRQDPRAVDALASALADGDPEGTARETALAALEYVRDPRVRTRLEWTTPRRA
>NZ_CP029197.1|WP_015032869.1|1866908_1868066_-|acetyl-CoA-C-acetyltransferase
MPEAYIVEAVRTPVGRRGGGLASVHPADLGAHVLNALVARSGIDPAAVDDVVFGCLDTVGPQAGDIARTAWLAAGLPEEVPGVTVDRQCGSSQQAVHFAAQAVLSGTQDLVVAGGVQNMSMIPIAFASRQAAEPLGLTGGPFHGSEGWRARYGDAPVNQFHGAELIAEKWRITRRDQEEFALRSHRRALAAIDTGRFTRETAAYGDVTTDEGPRRDTSAEKMAGLRPVVEGGTITAACSSQVSDGAAALLLASEDAVRAHGLTPRARIHHLSARGEDPIRMLSAPIPATAHALKKTGLAIDDIDLVEINEAFAPVVLAWLKETGADPARVNVNGGAIALGHPLGATGAKLMTTLLHELERTGGRYGLQTMCEGGGQANVTIVERL
>NZ_CP029197.1|WP_015032870.1|1868112_1868733_-|TetR/AcrR-family-transcriptional-regulator
MPNTADKKKTQVSGGPERRRELLDTAAEVFAAQGYNATTVRKIADAAGMLAGSLYYHFDSKESMLDEILSTFLGELWEGYDAVLAAGRGPRETIEALVTESFREIDRHRAAVAIYQKESRHLTDLPRFHYLADSQRKFEKAWLGTLERGVAAGVFRADLDVRLTYRFVRDTVWVAASWYRPGGLHSPEEIARQYLSMVLDGIAVRA
>NZ_CP029197.1|WP_015032871.1|1868748_1869540_-|SDR-family-oxidoreductase
MTRTPPPPYVPGHGLLAGRTAVITAAAGAGIGGATARRFLEEGARVLLSDAHTRRLKETETALAAAFGADSVAAQTCDVTDEAQVQALYDTAVRLHGRLDITVNNAGLGGTADLADMTDEQWNRVLDVTLGGTFRCTRAALRRFRDTGTGGVVVNNASVVGWRAQTGQAHYAAAKAGVMALTRCAAAEAAAYGVRVNAVSPSLAMHPHLAKVTTTELLDELTAREAFGRYAEPWEIANVIVFLAGDYSSYMTGETVSVSSQHA
>NZ_CP029197.1|WP_015032872.1|1869536_1870673_-|acyl-CoA-dehydrogenase
MSSVEEFRTEIRGWLKTHLSGSFAALRGRGGPGREHEAFAERLTWERHLAAHGWTCVGWPKEYGGRGASVAEQIAFHEEYALADAPARVNHIGEQLLGPTLVDHGTEEQKARFLPPIRAVEELWCQGYSEPGAGSDLAAVRTRATLTGGSWVIDGQKIWTSLAHEAQWCFVLARTEPGSTRHTGLSYLLVPLDQPGVEIRPIVQLTGTSEFNEVFFDGAVTDAAHVVGAPGDGWRIAMATLGYERGVSTLGQQVGFRRELDALVALARRNGAAADPDIRDRLTRAWAGLEALRAGALRGTDPSAAKLYWSHWHRDLGELALEVCGPAATLAAGAPYELDDWQRLFLFSRADTVYAGSSEIQRNIIAERVLGLPKEPRP
>NZ_CP029197.1|WP_015032873.1|1870730_1871876_+|acyl-CoA-dehydrogenase
MDLSYTRTEEAFRAEAREWLREHVPAEPLPSLETAAGFAAHRAWEAELAAARWSVVSWPEEYGGRGVDLAHWLVFEEEYWAAGAPGRVSQNGVQLLAPTLFDHGTAEQRARVLPSMATGETVWAQAWSEPEAGSDLASLTSRAVRTDGGWLLSGQKTWSSRAAFADRAFGIFRSDPDADRPHRGLTYLMFDLRAPGVTVRPIGRLDGKPAFAELFLDEVFVPDADVIGEPGQGWRIAMSTTGNERGLMLRSPGRFLAAADRLVGLWRAEGDPADSALRDRVADAVIGARAYQLFTAGAAARLATGAAAGADSSLNKVFWSEYDLALHETALDLLGPDGELADGAWAEGYVFSLAGPLYAGTNEIQRDIIAERLLGLPKGRR
>NZ_CP029197.1|WP_015032874.1|1871875_1872895_+|acyl-CoA/acyl-ACP-dehydrogenase
MGFLPTDEQRAFARSLDAMLTASDTPAAIRAWAGGEPGPGRALWGRLAEAGVFALAVPEAYEGMGPLPVELAHAFVELGRHAVPGPVVETVATAVLLGELARLGEPGPAKRLLPGLAAGEWTATLAAPATRAARHPVPYALDADRADAVLVVRGEELWRAPGHGPVRVSADPARRLARPAPGGELLAEGPAVAAAAAAARRWAMLATAAQSLGVGLALLDRSVAYARQRTQFGAPIGSFQAVKHRLADTLLALEFARPLLFGAAVALADGRAPDGDLAAAKVTAGEAGYGAARTALQVHGAVGYTEELDLSLWLRKARPLRDAWGAPAACRAAVLAPYA
>NZ_CP029197.1|WP_041662249.1|1872902_1873421_-|pyridoxamine-5'-phosphate-oxidase
MGDTGHPTTTWSAFEAAEPELAATVRERFGQHTHHALATLRADGSPRLSGIEVGFRFGELWLGMMPGSRKARDLRRDPRLSLLANLGRGTDMGGGDVRISGRAVEITDPETIARYVAEADEPQPFHLFRVEPTEVVRTWVDGDELVLRSWTAGRRARTFRRGNDESPPREGV
>NZ_CP029197.1|WP_015032876.1|1873518_1873908_-|VOC-family-protein
MSSLVRHVTIDCADAYALAGFWAKALDSTISDADKPGDEEVLVEAPGVGLLFIQVPEAKSVKNRIHLDLKPLDRTRDEEVERLIGLGATLFEDHRNPDGSGWATLADPEGNEFCVERSAAERAATAPAS
>NZ_CP029197.1|WP_041662250.1|1873952_1874543_-|PadR-family-transcriptional-regulator
MADEETVPALPATSWAVLGLLSFGRELSGYDIKKWSDRSLGLFYWSPSFSQIYSELKRLEQAGLAGSRLVPPEAGSRDKRVYRITDEGLAAVRTWARTAPLDPPVLKHGPMLRLWLGHLLEPERMREILAAHRAHAEGMRLRAEADAADASADEAWAYPRLTLRWAERYYAAERDLADAMLADIEELDPPEGTGRS
>NZ_CP029197.1|WP_015032878.1|1874638_1875766_+|LLM-class-flavin-dependent-oxidoreductase
MKFSMIFEAQLVDPTPDREHRVLHDCVEQAVLAEEMGFDRVWAVEHHSLTQYAHMSASEIFLTWVAARTRTLRVGHGVVTMPFGYQHPVRVAERAAMLDVLSGGRVDIGAGRGATRQEMRMFGVRPEDTRPQTEEALRIFAAAWREPEFEWHGTLDIGPGAVLPRPVQRPHPPLFMACSQHASLRQAAELGIGALVMGFAGAEDVRAMRTVYDEARAARDGSRLVSTEVNDHFSALCPTVVLDDADRALRLGTRGQRFFAESIAHWYGGAPAPTGYAEDEDHTAALAREREALVARLHEADIPARPVDTGTYNTDHAYGDAATAISYVERLREIGVDEVMCLIQMGTVPQEACLETIRQWGTKVIPHFRQPEPRS

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Crispr_ID: NZ_CP029197_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_8

2238367-2238471

Orphan

Consensus_repeat	Method
CCGTTGTCGCCGCTGTACGAGGACTTACGCCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_8

>merge|NZ_CP029197|8|2238367-2238471|CRISPRCasFinder
CCGTTGTCGCCGCTGTACGAGGACTTACGCCAGGCGGCAGAGCCGAGGGGAGCGCACTCGATGCACTCACCGCCGTTGTCGCCGCTGAACGAGGACTTACGCCAG

>NZ_CP029197|8|8|2238367-2238471|CRISPRCasFinder
CCGTTGTCGCCGCTGTACGAGGACTTACGCCAG	GCGGCAGAGCCGAGGGGAGCGCACTCGATGCACTCACCG
CCGTTGTCGCCGCTGAACGAGGACTTACGCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015033219.1\|2232241_2233846_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP029197.1\|WP_041662324.1\|2239395_2239803_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP029197.1\|WP_015033224.1\|2236402_2236768_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP029197.1\|WP_015033234.1\|2245242_2246253_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274647
NZ_CP029197.1\|WP_015033238.1\|2248815_2250150_-\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340831
NZ_CP029197.1\|WP_015033233.1\|2244064_2244931_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223065
NZ_CP029197.1\|WP_015033221.1\|2234422_2234845_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033217.1\|2229410_2230376_-\|endonuclease/exonuclease/phosphatase-family-protein	unknown	unknown	gnl\|CDD\|377028
NZ_CP029197.1\|WP_015033220.1\|2233931_2234336_+\|DUF4259-domain-containing-protein	unknown	unknown	gnl\|CDD\|372905
NZ_CP029197.1\|WP_015033237.1\|2248034_2248769_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
NZ_CP029197.1\|WP_079179224.1\|2243029_2243953_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
NZ_CP029197.1\|WP_015033226.1\|2237766_2238216_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033236.1\|2246946_2248038_-\|prenyltransferase	unknown	unknown	gnl\|CDD\|273702
NZ_CP029197.1\|WP_015033230.1\|2239849_2240479_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379276
NZ_CP029197.1\|WP_015033222.1\|2235181_2235640_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033239.1\|2250357_2250996_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380056
NZ_CP029197.1\|WP_015033235.1\|2246271_2246823_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033225.1\|2236907_2237783_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224995
NZ_CP029197.1\|WP_015033218.1\|2230511_2232242_+\|serine/threonine-protein-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP029197.1\|WP_106433697.1\|2235636_2236326_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015033219.1\|2232241_2233846_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.13537e-80
NZ_CP029197.1\|WP_041662324.1\|2239395_2239803_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	7.82492e-17
NZ_CP029197.1\|WP_015033224.1\|2236402_2236768_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.20584e-40
NZ_CP029197.1\|WP_015033234.1\|2245242_2246253_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274647	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family. Members of this protein family are predicted to be oxidoreductases dependent on coenzyme F420. The family includes a single member in Mycobacterium tuberculosis (Rv3520c/MT3621) but four in Mycobacterium smegmatis. Prediction that this family is F420-dependent is based primarily on Partial Phylogenetic Profiling vs. F420 biosynthesis. [Unknown function, Enzymes of unknown specificity].	4.31631e-160
NZ_CP029197.1\|WP_015033238.1\|2248815_2250150_-\|glycosyltransferase-family-4-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.15521e-66
NZ_CP029197.1\|WP_015033233.1\|2244064_2244931_+\|hypothetical-protein	gnl\|CDD\|223065	PHA03378, PHA03378, EBNA-3B; Provisional.	4.26535e-06
NZ_CP029197.1\|WP_015033217.1\|2229410_2230376_-\|endonuclease/exonuclease/phosphatase-family-protein	gnl\|CDD\|377028	pfam03372, Exo_endo_phos, Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12, and Nocturnin.	8.63304e-12
NZ_CP029197.1\|WP_015033220.1\|2233931_2234336_+\|DUF4259-domain-containing-protein	gnl\|CDD\|372905	pfam14078, DUF4259, Domain of unknown function (DUF4259). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 118 and 145 amino acids in length.	6.02552e-34
NZ_CP029197.1\|WP_015033237.1\|2248034_2248769_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	5.94322e-27
NZ_CP029197.1\|WP_079179224.1\|2243029_2243953_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	9.54829e-40
NZ_CP029197.1\|WP_015033236.1\|2246946_2248038_-\|prenyltransferase	gnl\|CDD\|273702	TIGR01577, Uncharacterized_glycosyl_hydrolase_MJ1610, oligosaccharide amylase. The name of this type of amylase is based on the characterization of an glucoamylase family enzyme from Thermoactinomyces vulgaris. The T. vulgaris enzyme was expressed in E. coli and, like other glucoamylases, it releases beta-D-glucose from starch. However, unlike previously characterized glucoamylases, this T. vulgaris amylase hydrolyzes maltooligosaccharides (maltotetraose, maltose) more efficiently than starch (1), indicating this enzyme belongs to a class of glucoamylase-type enzymes with oligosaccharide-metabolizing activity.	1.07171e-16
NZ_CP029197.1\|WP_015033230.1\|2239849_2240479_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379276	pfam13578, Methyltransf_24, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.19592e-23
NZ_CP029197.1\|WP_015033239.1\|2250357_2250996_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380056	pfam17925, TetR_C_20, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the transcriptional regulator KstR that regulates a large set of genes responsible for cholesterol catabolism. This is important for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma.	6.58553e-37
NZ_CP029197.1\|WP_015033225.1\|2236907_2237783_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|224995	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism].	5.84392e-40
NZ_CP029197.1\|WP_015033218.1\|2230511_2232242_+\|serine/threonine-protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.97687e-83

>NZ_CP029197.1|WP_015033226.1|2237766_2238216_-|hypothetical-protein
MATLIGTMILAIGLPAWAGITYVGLVRARRGDELPQPRPPRRPRSPARKAAWGAGLAYLAGGALHLYGLSYMPFLFPEDACWFGVGIKAYPDSSSALPVSLVCRGIEVVPWWVNPGLLVLAVTAVAATVASVVLAVRGSRRAAAVRRGA
>NZ_CP029197.1|WP_015033225.1|2236907_2237783_+|NAD(P)-dependent-oxidoreductase
MTNDNSLQVSVLGLGAMGSALATALLKAGHPTTVWNRTPGRADDLVALGATPAGTTADAVRASPLVIACLLDHASVHDVLDPLTDDLAGRTLINVTTTSPTQSRELAAWAARAGVTYLDGGIMAVPHMIGLPGSSILYSGSADAFHQHKPLLDLWGTSTYYGDDAGLASLYDLALLAGMYVMFAGFIHGAAMVAPAGITARQFAASAAPWLSAMTGGLAGFAEVIDGGDYTVAGQQSLEFSHLGDLQAASAEQGISTEVVDMVQRLIQRQIDAGHGTEGFARIFESLRHPA
>NZ_CP029197.1|WP_015033224.1|2236402_2236768_-|helix-turn-helix-transcriptional-regulator
MAASARRGPYFCGIDAAMDVVSGKWKVLILWELDHHGVRRFAELRRGLPGVSEKMLVQHLREMEEDGLVHREVYAEVPPKVEYSLTARGTSLNAALAPLGAWGGERIREIGAEKVSVGSFG
>NZ_CP029197.1|WP_106433697.1|2235636_2236326_-|hypothetical-protein
MDVETHAEDPYPDVTAAGGLVAALRQTAEARGRDIGLSPYVTEAVGMESRRGYLSVDTASGERLFRLRTSIPDFGWYIGGTDDLGTLVDAIAAWREDVPLDALKARFDFLDLDEFTRALASGEPTSSQWAHLLSSEYYRPQRNLLRRLHADEVLRNAFPTMTHRAVRLRVDPMDYTSRQALVEETDEGRYSTVTVGAPGATWTEVPDEQLIAYLRTALHENRLQCEKRR
>NZ_CP029197.1|WP_015033222.1|2235181_2235640_-|hypothetical-protein
MTEFGFARASDDVIARRGELAEQVVQALRRAGLPAFRDGGSGSPDRVGAVVHVDPDAETASAAVSVGWRCDPGVARAALDALAAGSPADAPVVRRPGSIGLRMQGALVGILLSAGLIATPEHDEMNPDHVLVFGQMSDLPPALRPTFVPPGS
>NZ_CP029197.1|WP_015033221.1|2234422_2234845_-|hypothetical-protein
MNKPRFDLPPQAPPELIAQWNELAAQVCRELARAGLPARRADLDGGSLDKPGADVHVDRVLDGGVYVDWRANAELRAAAAELFAKGIDYADPPAVVRHFENVQNSMQKALLGILASAGFQVEESDPFTHGSAVYVKGLRP
>NZ_CP029197.1|WP_015033220.1|2233931_2234336_+|DUF4259-domain-containing-protein
MGTWDIGPFDNDTAADFSYRVDEAPAEKKAEVLRTAFREVIETGDEYLDADLADEAIASAALLAAQCPGGTPVTTSYGPKHPLPPLPTDLRPQAVTALDRILTEPSELLELWEESDGEEWKAGVRQLRAVLAGT
>NZ_CP029197.1|WP_015033219.1|2232241_2233846_+|serine/threonine-protein-kinase
MKPLGPADPATAGPYRLLAELGQGGMGRVLLGAAPDGRLVAVKQVHARFAADDGFRARFRREVAASRQVSGAYTAAVLDADTEARLPWLASAFVAGPSLGAAVEDAGVLPEEAVRRLAAGLATALVEIHRTGIVHRDLKPENVLLAEDGVRVIDFGIARVAEGADATALTHTGWVVGSAAFMSPEQAEGRELTPASDVFALGAVLAMAATGDSPFSGTSMAGTLYNVVHREPDLTTLPPGLAALVGPCLAKAPADRPTPRQLLALLGPIPAAERPWPPSVHGLIATQQTEIDRLLDTTDRTPAPDAYSPTRVSPSAPGPGFGPPLPVAGTPRRGRARKITALVLAGVLAVAGLGVGAYVLTTRGDGAGGASGPPDKYAKIPTCAEAAGRLGLPERKKDRDAYGDRTNEASTSCTWIGTLDLGGGYVLENAYTLAYVQWTLKRTVENDKNATGLQRAEFAEGAADGTRDSGLGIGDEAYWDRPDGPDEHCDLRVRDGNLTLWVELGGDEHPEATCKTEAARIARAALAAVPPQGH
>NZ_CP029197.1|WP_015033218.1|2230511_2232242_+|serine/threonine-protein-kinase
MGVSGVPGSAHIGPFRVVAELGQGGMGRVLLGVAPDGRLVAVKQVHAELAGDDGFRARFRREVTASRQVSGAYTAPVVDADPDAETPWFAAQFVPGPSLSQALDAVGALPLESSRLLAAGLAQALADVHRAGLVHRDLKPSNVLLAEDGVRVIDFGIARAAEGQTKLTHTGAMVGSPPFMAPEQVDGRQLTAAADVFSLGSTLVMACTGRPPFTGTSVPGILYNVAHSEPDLSAVPPALLPLIEACLAKDPAQRPSPQALLSMIGPVRPSARPWPEAVHRLALAQRAEIDRYVAGAGGSATRTDAAPPPADAAPFAPASLHHAPTMTAAAQAPHLPAAPPHPAYQGYDGNQGQQGYPSPPASPPTPGLRRKRRAWIAGGSVAALATAIALLATFLPPEMNPFHTEAVPTPGNTPLAQVADKYTGTPPSCKEISGEVKVPAEFALQPMPYGSEISDHEDFDDKALYQQGRCIWQSRSGDKIDLTWDQYRTAKDKTGAERAKKHYESLYIAGTTHREDIGTGEEAFWHGEPDRGCVLYARDVNFYVFVAVEGTAYPTGDKCEALAVSVAKGTYEAGSA
>NZ_CP029197.1|WP_015033217.1|2229410_2230376_-|endonuclease/exonuclease/phosphatase-family-protein
MRASFRTLLAALFSIGLLLGAGPAQADVVTPQDAKPLRFISYNVCGASCPLPAETDAARAAWVSGLVAEIDAWDSDLIMLQELCYGQWTLIRDRLAQRTGEDSYDSVWGAALPSAAKCGQWNANDRRFGLAIFSKGKASFVDGTRSVTFLPEDPLNPTEDRILLCAQTALRGVAVRACNTHVDFNDTTTALQVPKVAELVDAARQGGEPAILAGDFNQVPEHADMNALYNHGGGSAGRFQEVDENDKEQFKGDGCPQTADRCRSGEPTASPTCSDHTKETSKIDYVFLSYEWFKTVQGDALPCPPGMSDHHLLRGAAAWER
>NZ_CP029197.1|WP_041662324.1|2239395_2239803_+|ATP-binding-protein
MNQATDLYPAVLATSYRMRFTVGEHSAGHMRRILRMFLTRWELDRLADAAGLALTELVANVVRHVPGRHCAVLILREPYGLRVEVADAVPGAVHAKAADPLDAGGRGLVLVEAVTDRWGVDERADGKTVWFECDA
>NZ_CP029197.1|WP_015033230.1|2239849_2240479_+|class-I-SAM-dependent-methyltransferase
MSEPAPEILAAFEAAKGFMPVGEGLALYAAAAEAAKLGLPLLEVGTYCGRSTILLADVARRAGTVAVTVDHHRGSEEQQPGWEYHDETVVDPEVGLMDTLPTFRRTLRKAGLEEYVIAVVGRSPQVAKVWGGQLGLVFVDGGHTDEHATNDYEGWAPKVAPGGLLVIHDVFPDPADGGQAPYRIYLRALESGDFDEVSVTDSLRVLRRR
>NZ_CP029197.1|WP_079179224.1|2243029_2243953_+|N-acetylmuramoyl-L-alanine-amidase
MPYDHRKTSRRARPRTLALVLAATGCCAVLAGCGAPEVSPPGGKSAESPTASRTTNGGATTTAPAPQGSPTAGHGGPSVQAGARTLAGRTVVIDPGHNSGNFRHSSEIDQKVNIGTNRKECDTTGTSTNGGYTEASFTLDVSRRLRELLTARGAKVVLTHDADRAWGPCIDERAKIGNAARADAVVSVHADGSAVGHRGFHVILPARVREGAADTAKIVGPSRELGERIAAQFARATGTAPANYLGSGTGLDVRDDLGGLNLSTVPKVFVECGNMRDPKDAQLLTSAAWRQRAAQGIADGIATYLKG
>NZ_CP029197.1|WP_015033233.1|2244064_2244931_+|hypothetical-protein
MNIRSLTRGDGVLIGAAVVLFIASFLGISGCDAPEAICDQVNNPNSWELSYLGWGAFFLGLAGAALVVFSRSLPQPLKVAGLDLGQVGAAFTVAAAWNLLMWIFEAENAGAGLVLGLIAALVLAGAAVAGPMVPALKAPLVGAPKPPTPQPYGMQPGQPGPQGVPGGYGYPGAQHPQYGGPQDASQGAGQPFGAQAAAAQPQAAQQSEPQGQAAPAPQAQPAGDFSPFWFAVPVARPLYAEDGSQAPIAELAPGTWYLAVEQRGAALVAQTQDGRRGVLQDTTGIQRG
>NZ_CP029197.1|WP_015033234.1|2245242_2246253_+|LLM-class-F420-dependent-oxidoreductase
MRLGLALGYWGRGPSAAHLDLAREAERLGYDSVWTAEAWGSDAFTALTWIAAHTSRIRLGTAVAQMAARAPTTTAMHALTLDHLSGGRVMLGLGLSGPQVVEGWYGRPFPRSPLTATREYVDVVRQVLRREAPVRLEGRHHSHPYTGPDGTGLGKPLKPITHPLRADLPILLGAEGPKNIAQTLAIADGWLPLYWSPGRWAEVYALPERLPEGFLVAPMVRAQLCEDVAAGLLPVKAMLGFYIGGMGHAARNFHADLMGRMGYEKEARRVQELFAAGRREEAVLAVPDAFADEISLVGPRERIAERLETWRRGPVTDLLVTSPDPATLRLLAELNS
>NZ_CP029197.1|WP_015033235.1|2246271_2246823_-|hypothetical-protein
MPRSLSRGVVALLLSCTLLMTTAACNDGDDTQSASSAVTPTSSAGFEQQKLAKTRFVANAGLAAGAAYQWIVKPYRAGKFKKGADGRTFALVKAGLAGAFTYNRLKAAVNNAKGDPLLSKAVAPLTAGIDSLKDLGTKLRKGEAGDADVGAFESVINSVKDAGKSAGAEVVDKVPSASQLSGG
>NZ_CP029197.1|WP_015033236.1|2246946_2248038_-|prenyltransferase
MTSPERIAEHLVLPGVLTAEQAAETVAGILAVQREDGALPWFRGHHLDPWDHTEAAMALDAAGEHTAAARAYEWLARHQNGDGSWYAAYHDGEPDQVTDSGRESNFTAYIAVGVWHHYLSTGDDAFLDRMWPTVYAAVEFVLGLQQPGGQIGWKREADGTPVNDALLTGSSSIHQALRCALAIAEAREEPQPDWELAAGALGHAIRRHPERFLDKSRYSMDWYYPVLGGAITGPEAKARIEADWDTFVVPGLGVRCVVPNPWVTGGESCELALALWAVGESDRALTILQDIQHLRAANGMYWTGYVFEGETESDKAMWPEEQTSWTAGSLLLAVAALGGEEATVAVFGGERLPAGLEPDCCGT
>NZ_CP029197.1|WP_015033237.1|2248034_2248769_-|class-I-SAM-dependent-methyltransferase
MLTVDFTRFPLAPGDRVLDLGCGAGRHAFECYRRGAQVVALDQNGEEIREVAKWFAAMKEAGEAPAGATATAMEGDALNLPFPDASFDVVIISEVMEHIPDDKGVLAEMVRVLKPGGRIAITVPRYGPEKICWTLSDAYHEVEGGHIRIYKADELLGKIRQAGLKPYGTHHAHALHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPALTRVAEQLLNPVVGKSFVAYATKPHLPKADTQ
>NZ_CP029197.1|WP_015033238.1|2248815_2250150_-|glycosyltransferase-family-4-protein
MTAEAIEASPRQGVTATGRDPLRIALLTYKGNPFCGGQGVYVRHLSRELVRLGHHVEVIGSQPYPVLDEGEDLAGLTLTEIASLDLYRSPDPFRTPKREEFRDWIDGLEVATMWTGGFPEPLTFSLRARRMLAARRGDFDVVHDNQTLGYGLLGGPRAIGAPLVTTIHHPITVDRQLDLDAAADWKRRASVRRWYAFTRMQKRVARRLPSVLTVSGTSRREIVDHLGVREDRIRVVHIGADTDLWSPDPAVAEVPGRIVTTSSADVPLKGLIHLIEALAKLRTENPDAHLVVVGKRAEDGPVAAAIERYGLDGAVSFVKGISDAELVDLVRSAQVSCVPSLYEGFSLPAAEAMATGTPLVATTGGAIPEVAGADGETCLAVPPGDAGALAVALGRVLGDAQLRARLGAAGRARVLERFTWARAAQGTAELYREAVARQGAGARR
>NZ_CP029197.1|WP_015033239.1|2250357_2250996_+|TetR/AcrR-family-transcriptional-regulator
MTADIRADHRPASPPLTERQEARRRRILNASAQLAARGGFDAVQMREVAEAAGVALGTLYRYFPSKIHLLVATMQDQLQHMHTTLRKRPPAGADPADRVAETLMRAFRALQREPQLADAMVRALTFADRGVSPEVDTVSRLTTAIILDAMGAEHPTPEQLSAVRVIEHTWHSALITWLSGRASIAQVKIDIETVCRLIDLTAPSPGTDSPAS

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Crispr_ID: NZ_CP029197_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_9

2264951-2265038

Orphan

Consensus_repeat	Method
CCGGAACCCGGCCGGAACCGGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_9

>merge|NZ_CP029197|9|2264951-2265038|CRISPRCasFinder
CCGGAACCCCGCCGGAACCGGAACCCGGCCGGAACCGGAGCCCGGCCGGAAGCGACCCGGCGGCGCCGGAACCCGGCCGGAACCGGAA

>NZ_CP029197|9|9|2264951-2265038|CRISPRCasFinder
CCGGAACCCCGCCGGAACCGGAA	CCCGGCCGGAACCGGAGCCCGGCCGGAAGCGACCCGGCGGCG
CCGGAACCCGGCCGGAACCGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_106433829.1\|2256984_2257611_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033243.1\|2252688_2254152_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143457
NZ_CP029197.1\|WP_015033255.1\|2267752_2268094_+\|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl\|CDD\|225209
NZ_CP029197.1\|WP_015033248.1\|2258716_2260465_+\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213192
NZ_CP029197.1\|WP_015033251.1\|2262231_2263401_-\|steroid-3-ketoacyl-CoA-thiolase	unknown	unknown	gnl\|CDD\|181145
NZ_CP029197.1\|WP_015033244.1\|2254274_2255336_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293811
NZ_CP029197.1\|WP_158506252.1\|2267415_2267574_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033260.1\|2273077_2273746_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319829
NZ_CP029197.1\|WP_041663801.1\|2269560_2271633_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_CP029197.1\|WP_015033247.1\|2257607_2258720_+\|cobalt-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223692
NZ_CP029197.1\|WP_015033254.1\|2266157_2266826_+\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607
NZ_CP029197.1\|WP_146250776.1\|2272179_2272893_+\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP029197.1\|WP_015033249.1\|2260590_2261454_+\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|378961
NZ_CP029197.1\|WP_078508868.1\|2268154_2268631_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP029197.1\|WP_015033261.1\|2274171_2274822_+\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|377857
NZ_CP029197.1\|WP_015033250.1\|2261740_2262142_+\|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl\|CDD\|366654
NZ_CP029197.1\|WP_015033245.1\|2255686_2256934_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|239222
NZ_CP029197.1\|WP_015033257.1\|2268643_2269450_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029197.1\|WP_015033252.1\|2263629_2264895_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP029197.1\|WP_015033253.1\|2265063_2266161_+\|DUF2330-domain-containing-protein	unknown	unknown	gnl\|CDD\|370813

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015033253.1\|2265063_2266161_+\|DUF2330-domain-containing-protein	gnl\|CDD\|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	6.04235e-77
NZ_CP029197.1\|WP_015033243.1\|2252688_2254152_-\|aldehyde-dehydrogenase	gnl\|CDD\|143457	cd07139, ALDH_AldA-Rv0768, Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like. The Mycobacterium tuberculosis NAD+-dependent, aldehyde dehydrogenase PDB structure, 3B4W, and the Mycobacterium tuberculosis H37Rv aldehyde dehydrogenase AldA (locus Rv0768) sequence, as well as the Rhodococcus rhodochrous ALDH involved in haloalkane catabolism, and other similar sequences, are included in this CD.	0
NZ_CP029197.1\|WP_015033255.1\|2267752_2268094_+\|antibiotic-biosynthesis-monooxygenase	gnl\|CDD\|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	4.27905e-23
NZ_CP029197.1\|WP_015033248.1\|2258716_2260465_+\|energy-coupling-factor-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	1.54001e-80
NZ_CP029197.1\|WP_015033251.1\|2262231_2263401_-\|steroid-3-ketoacyl-CoA-thiolase	gnl\|CDD\|181145	PRK07850, PRK07850, steroid 3-ketoacyl-CoA thiolase.	0
NZ_CP029197.1\|WP_015033244.1\|2254274_2255336_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293811	cd07725, TTHA1429-like_MBL-fold, uncharacterized Thermus thermophilus TTHA1429 and related proteins; MBL-fold metallo hydrolase domain. Includes the MBL-fold metallo hydrolase domain of uncharacterized Thermus thermophilus TTHA1429 and related proteins. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	7.5144e-46
NZ_CP029197.1\|WP_041663801.1\|2269560_2271633_-\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.41526e-96
NZ_CP029197.1\|WP_015033260.1\|2273077_2273746_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.4503e-64
NZ_CP029197.1\|WP_015033247.1\|2257607_2258720_+\|cobalt-ABC-transporter-permease	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	2.42403e-10
NZ_CP029197.1\|WP_146250776.1\|2272179_2272893_+\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	3.59606e-11
NZ_CP029197.1\|WP_015033249.1\|2260590_2261454_+\|ECF-transporter-S-component	gnl\|CDD\|378961	pfam12822, ECF_trnsprt, ECF transporter, substrate-specific component. Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.	2.43384e-14
NZ_CP029197.1\|WP_078508868.1\|2268154_2268631_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.93336e-13
NZ_CP029197.1\|WP_015033261.1\|2274171_2274822_+\|HNH-endonuclease	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	6.94958e-13
NZ_CP029197.1\|WP_015033250.1\|2261740_2262142_+\|transglycosylase-SLT-domain-containing-protein	gnl\|CDD\|366654	pfam01464, SLT, Transglycosylase SLT domain. This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.	5.85051e-06
NZ_CP029197.1\|WP_015033245.1\|2255686_2256934_+\|hypothetical-protein	gnl\|CDD\|239222	cd02892, SQCY_1, Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.	1.99216e-07
NZ_CP029197.1\|WP_015033257.1\|2268643_2269450_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.76006e-06
NZ_CP029197.1\|WP_015033252.1\|2263629_2264895_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.88713e-91
NZ_CP029197.1\|WP_015033254.1\|2266157_2266826_+\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	1.56876e-57

>NZ_CP029197.1|WP_015033252.1|2263629_2264895_+|cytochrome-P450
MAACPHLPEGHLPEGFDATDPDLLRERVPFPEFTRLRQTAPVWWCPQPPGVTGFADGGYWAVTRHADVKYVSTHPELFSSNENTAVIRFNEHITRDQIEVQKLIMLNMDPPEHTRVRQIVQRGFTPRAIRSLETALRDRAHAIVDEARRGADADGTFDFVTRVAVELPLQAIAELIGVPQEDRSRIFDWSNKMVAYDDPEYAITEEIGAEAAMELIGYSMNMAAARKECPAADIVSQLVAAEGQGNLSSDEFGFFVLLLAVAGNETTRNAISHGMHAFLTHPDEWELFKRERPATAAEEIVRWATPVVSFQRTATQDTELGGQKITKGDRVGLFYSSANNDPEVFTDPERFDITRDPNPHLGFGGGGPHFCLGKSLAIKEIELIFNAIADALPDLTLAGEPRRLRAAWLNGVKELRVRASA
>NZ_CP029197.1|WP_015033251.1|2262231_2263401_-|steroid-3-ketoacyl-CoA-thiolase
MAAEPVIVEAVRTPIGKRGGALANLHPAYLLGETYRELLGRTGIHADCVEQIVGGTVTHAGEQSMNPARTAWLTMGLPYETAATTVDCQCGSSQQASHMVANMVAAGVIDIGISCGVESMTRVPLGSGSKHGPGKPFPDEWNVDLPNQFEAAERIARHRGLTRERVDSLGLLSQERAANAWSEERFKRETFAVQVPTTEEEQAAGQGMWRLVDRDEGLRDTTMEGLARLKPVMPTAVHTAGNSSQISDGAAAIMWASKRMARALKLKPRARIVAQALVGADPHFHLDGPVDATRAVLGKAGMSLRDIDLVEINEAFASVVLSWAQVFDQDLEKVNVNGGAIALGHPVGATGARLITTALHELERTDKEFALVTMCAGGAVATGTIIQRL
>NZ_CP029197.1|WP_015033250.1|2261740_2262142_+|transglycosylase-SLT-domain-containing-protein
MIRSLATRVSARKKTFAASAAVLLGASGAVLGTTGSASAASPQELAREIVPASQYASFSKIVEHESHWNHTATNSSSGAYGLVQALPASKMSSAGSDWKTNPATQIKWGLNYMNERYGSPNAAWAFWQANGWY
>NZ_CP029197.1|WP_015033249.1|2260590_2261454_+|ECF-transporter-S-component
MGARPVRLGPRSVTALVLVSLVGLAAFCWPLFADAGSAVTSHAGDAPWLFAALLPLLVAVVVATIADCGMDAKAVAMLGVLAAVGAALRPLGAGTAGLEPMFFLMVLSGRVLGPGFGFVLGAVTMFASALLTGGVGPWMPFQMLSMGWFTMGAGLLPGPGRLRGRGELLMLSAYGFAAAFAYGTIMNLQGWVLLQGLSSGISFQPGAPPYENLVRFLAYVTATSLGWDLGRAVLTVVLTLTIGGTLLRALRRATRRANFEAQVTFGGLEKPPAGEAPHRTYVTYEPE
>NZ_CP029197.1|WP_015033248.1|2258716_2260465_+|energy-coupling-factor-ABC-transporter-ATP-binding-protein
MIRFENVSVTYEGADERHEPTLRDVNLTVPEGELVLLVGPSGVGKSTLLGAVSGLVPHFTGGTLTGRVTVDGRDTRTHPPRELADLVGTVGQDPSAHFVTDTVEDELAYGMESLGLAPGVMRRRVEETLDLLGLAELRDRPIATLSGGQRQRVAIGSVLTPHPKVLVLDEPTSALDPSAAEDVLAVLQRLVHDLGTTVLLAEHRLERVVQYADQVLTLPEGVMGSPAEIMAVSPVHPPVVGLGRLAGWDPLPLTVRDARRRAGGLKAELEGRTWNPARPAFEDRGSDGPENSAPPAFEARGSGGGAPGFGKGRGGGINPFKRRRTPAPAPATTPLVLTDALAVRRGRVEALRRVDLRVQAGETIALMGRNGAGKSTLLSALVGMIAPTSGTVRVAGRAPHATSPRELIRQVGLVPQEPRDLLYADTVAAECVAADADAGAEPGTCRALVSELLPGVSDATHPRDLSEGQRLALALAVVLTGRPPLLLLDEPTRGLDYAAKARLVARLRTLAAEGHAIVLATHDVELAAELAHRVVIIADGEVVADGPTAEVVVSSPAFSPQVAKILAPQPWLTVEQVAEALR
>NZ_CP029197.1|WP_015033247.1|2257607_2258720_+|cobalt-ABC-transporter-permease
MNLRVALRAPEADRANALHAGAWWLWALGLAVAASRTTNPLLLGLLVGVAGYVVAARRTDAPWARSYGAFVKLGLFVVALRVVFSLILGSPIPGTHQLFTLPEVPLPDWAQGVRIGGRVTAEQLVFAVYDGAKLATLLICVGAANALANPARLLKSLPGALYEAGVAVVVAMTFAPNMVADVARLRTARRLRGRPTGGVRAVLQIGLPVLEGALERSIAVAASMDARGYGRTARVPASVRRTTNVLTLGGLLGVCAGSYGLLAAEGAGYGLPLLGAGLLAAMAGLRLGGRRTVRTRYRPDRWGARAWLVAGSGVAVAVLMIWANAYAPEELHPGVVPLEAPELPLWPAVSVLVGLVPAFVAPVPPAKEKT
>NZ_CP029197.1|WP_106433829.1|2256984_2257611_+|hypothetical-protein
MLTLTGVVAAAAPAQAAGYRYWSFWESAGGKPWAYATQGPATARPADGDAIGFRFAISNGTNDTSQPTVTPDFPGICGGVAQKDGTKRVAVVVDFGGPADAPPGETPPEKLIKVGCAQVREDATGAEALAAVAKPLRYDSAAMLCGIAGYPARGCGEPVGDQAAASAAPSASASAGEGGGGPSLGVLVGGAAVLALGGAAVWKARRRG
>NZ_CP029197.1|WP_015033245.1|2255686_2256934_+|hypothetical-protein
MNTVRRGAAALAAATALLGTGAAGAATAAPSPSPSPVTIPDGLYGTKDPTYDGVWRQSLAFLAQRAAGFQPSDKAVGWLFDQQCEDGSFSSFRADDKAPCDAKTMRDTNATALAVQALQAVRNQSTFPEKADKAVKAGSDWLRSVQNKDGGWGYNPGGASDANSTSVVIGALAATGARPASFTSAEGRTPYDALLTFALPCSDKAGPGAFAYQPDKAGKLLANADATAAATLAGLGKGVVATKASPEQPPVCNDLSKPTIERASLNGASYLAKALAKTGHLNLPPMPGATDTSEQPDVGNTADAVVALAASGAAKEAKPALEWLEKNSAAWAKEGGPAAYAQLILAARATDTDPREFGTADLVEQLNATGPAPKTPDTSASSTSDDEGGFDVWWIIGIGMVVGVGIGFLVSGRKK
>NZ_CP029197.1|WP_015033244.1|2254274_2255336_+|MBL-fold-metallo-hydrolase
MQGSTQGPAPRVTEHGGGVWALRVPIPDNPLGHTLVHVLDTDRGPVLVDTGWDDPDSWTELTAGLDALGLSVRDVHGVVITHHHPDHHGLSGRVREESGAWIAMHAADTAVVRRTREAEPGTWLDYLARKLAAVGAPEDHLAPLRAARAPGRTRTLPGLRAALPDREIVPGELLDLAGRRLRAIWTPGHTPGHVCLHLEEEHPARRPGHGRLFSGDHLLPGITPHIGLYEDPDDATETDPLGDYLDSLERIGRLGVAEVLPAHQHSFTDAAGRVRELLDHHEERLTGLLGLLATPLTPWQLAVRMEWNRPWDQIPYGSRNIAVSEAEAHVRRLVKLGRAEAVPGTEPVAYVAV
>NZ_CP029197.1|WP_015033243.1|2252688_2254152_-|aldehyde-dehydrogenase
MTELVEHGKLFIGGELTDPLGADVIEVVSPHTEEVIGRVPHASTADVDAAVAAARRAFDEGPWPRMTLEERIAVVGRIKDAIAVRHEEIARSISAQNGSPYSWSVLAQALGAMMVWDAAITVARDFTYEERRGGVLGPLLVRREPVGVVAAVVPWNVPQFTAAAKLGPALLAGCTVVLKPSPESPLDSYILADIATEAGLPEGVLSIVPADREVSEYLVGHPGIDKVSFTGSVAAGKRVMEVASRNLTRVTLELGGKSAAVILPDADLATAVAGIVPAAWMNNGQACVAQTRILAPRSRYEEIAEAFAAAAGALVVGDPLDPATQVGPLVAQRQQRRSLDYIRIGQDEGAKVLAGGGRPAGLDRGWYVEPTLFGGVDNSMRIAREEIFGPVICLLPYGDEAEALRIANDSDFGLSGSVWTGDVEHGVDFARGVRTGTFNVNTFSLDMLGPFGGYKNSGLGREFGPEGLGEYLEHKMIHLPAGYEGGA
>NZ_CP029197.1|WP_015033253.1|2265063_2266161_+|DUF2330-domain-containing-protein
MRGTHRILATIVALLALQLGSLVAPAYACGCGAMIPTKEQRIGVDREESAVRWDGRTETVVMRFNVHGNARHAAWIMPVPHRADVSLGDPELFDEIGRLTEPEQRDRFHFWPRADDWPFDTDYGDGAGAPAPGAGTVGVVGRERLGPFDVARLTATDPEALGDWLRTHGYELPERLTGALQPYVDRRWEYVAVRLAPDEKDATLQGELTPLRITFASTELVYPMRLSRLATTSQSLGLSILSEHRMEPRSPIGGDAPEVTFAGRIERPSGALAALAGDRPVHLTVLEQEFPHPERIDDDHHLRAVADTPYRQVEYTDRLLTVGDGIPVWLLTVGGAVILAAVAALLAVRAARRRPTADTGVRSAP
>NZ_CP029197.1|WP_015033254.1|2266157_2266826_+|O-methyltransferase
MTNPQWNAVDAYFTETIAPADEVLTAALADSAAAGLPEIAVAPNQGKLLHLLALTQGARTVLEIGTLGGYSTIWLARALPADGRLITLEYDPAHADVARANIARAGLEKIVEVRTGAALDSLPLLEAEDAGPFDLVFIDADKVNNPRYVEWALKLSRPGTLIIVDNVVRGGKITTPHPEDPAITGTRELFDLVAAEPRLDATALQTVGAKGYDGLLLARVVA
>NZ_CP029197.1|WP_158506252.1|2267415_2267574_+|hypothetical-protein
MTTKRGASEHTIRPALELRIGGLHLTVQRIPPLLVALITTAGGAAGTWWAQR
>NZ_CP029197.1|WP_015033255.1|2267752_2268094_+|antibiotic-biosynthesis-monooxygenase
MPSVVKINVLTVPAEQRAVLEQRFASRAGAVEGSDGFEWFELLRPVEGTDQYLVYTRWRSEEDFQNWMNGSMKAAHGGGGEGGGEGGGERPKPAASGSTLWSFEVVQQASPKG
>NZ_CP029197.1|WP_078508868.1|2268154_2268631_+|GNAT-family-N-acetyltransferase
MTWTFTPEHVHTPDAVALRRGYYDDVASRYWKRPATEAEIDEGLAGDGVERLTPPTGQFLVARHEGEPAGCGGVLLLDAERAELTRVFLRHAFRGLGGAAGLMRNLEDAARALGARRMVLNTRLDLVEARAVYTRHGYAEIPAYCTGPYMDIWYGKEL
>NZ_CP029197.1|WP_015033257.1|2268643_2269450_-|hypothetical-protein
MNSEEPRQGWPAPPGHPPTGPAGGPGGYGGPQGYGGYAAPAAPPTPPRTTSHRGAWIGAAATLVAAVIGVVGTYLVSSNNSNNSNNAAKPTPPQAQGPATSAGSPQTPESTATAGSTPGAESSATPSTEPPATPTGKPSGKPAGTVEWQGPLAIEYAEPKDLDSAPPAESEIREENDLSVYPFGDHMLRPEDGTKVLVWKDATNKTPSYEECARDIETLGTTTDLKLKTGLVVCATTDDGRLARLTVKELSGLASDTRGVFDVVVWSR
>NZ_CP029197.1|WP_041663801.1|2269560_2271633_-|MFS-transporter
MAQEVRPAPPGGGAPAPGEAQSHRTVLVAIGALLLGMLLAALDQTIVSTALPTIVSDLGGLEHLSWVVTAYLLASTAATPLWGKLGDQYGRKKLFQAAIVLFLIGSALCGMAQNMPQLIAFRALQGLGGGGLMVLSMAIVGDLVSPRERGKYQGLFGAVFGATSVLGPLLGGLFTEHLSWRWVFYINLPIGIVALFVIAAVLHIPVRSTRHTIDYLGTFLIASVATCLVLVASLGGTTWAWGSAQIIGLAVLGAVLLVWFVYVERRAAEPVLPLKLFRIRTFSLVAVISFVVGFAMFGGMTYLPTFLQVVQGVTPTMSGVHMLPMVAGMLITSTASGQIVSRTGRWKVFPIAGTALTALGLLLLNELTETTSTWVMSVYFFVFGAGLGLVMQVLVLVVQNAVAYQDLGVATSGATFFRSIGASFGVAVFGTIFTNRLTHKLDDVFAGAAASGQELPPGVGADQVAADPRAIGQLPAALRPSVLHAYATSITDVFLYAAPVVLVAFVVAWFLKEDKLRASVTAPDTSQTLASNPVERSSYDECARALSVLGSREGRKAIYEKITARAGLDLLPAASWLLLRIRRHGTVEPARLAEHVPVPLRVITEASRQVEERQLATREGLQLVLTEEGVAVATRLAAAREESLAELLGDWWGPDRPTDLVKLVEELTAELSGSDGERPHDPEPPRDHHA
>NZ_CP029197.1|WP_146250776.1|2272179_2272893_+|peptidoglycan-binding-protein
MPLLLRGVSDVPPPPGHERGEGRGRGRRRGMLVAAVAAVAVAGTAALAAAVLGGGEGTDDRAAVPDVTTSASLNLAVSEAPSASSGSPEPRTSSPTPSRTPTPTSSSPSPSASRTTSTPSAPARTTGAAAPPASSSAPVTAPTTTRPATTTPPAEVPGEGEEEAVTLSLGSSGPEVRELQRRLEAVWAYHGRINGRFDEEVQEAVARYQSWRYVQDDPEGVYGPTTRRLLEENTPEV
>NZ_CP029197.1|WP_015033260.1|2273077_2273746_+|HAD-IA-family-hydrolase
MPATTPATLTARALLLDMDGTLVNSDAVVERCWRRWAERHGLDADAALKVVHGRQGYATMAVLLPDRPMEENYADNRVMLAEETADLDGVVPVPGAPAFMAALAELPHALVTSADEALAQARMGAAALPMPETRVTAECVGASKPDPEGFLKGAAELGFAPADCVVFEDSEAGIQAGRAAGMRVVGVGPRAAAFAPDVHVADLTHLRVEPAADGGIALTVLP
>NZ_CP029197.1|WP_015033261.1|2274171_2274822_+|HNH-endonuclease
MPVGMIYARRLAVLATSATLAGTGFLATAPAAQAAMPTPVSAATARTYLAALTVKAEGSSSGYSRDLFPHWITQSGACNTRETVLKRDGVNVVTDSSCAATSGSWYSQYDGATWTVASDLDIDHMVPLAEAWRSGANSWTTSQRQSFANDLTRPQLIAVTDNVNQSKGDQDPAEWLPSRTAYRCTYARAWVHVKYYWNLSVDSAEKSALQSVLNGC

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Crispr_ID: NZ_CP029197_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_10

2429343-2429447

Orphan

Consensus_repeat	Method
TGCTCTGCCAATTGAGCTACAGGGGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_10

>merge|NZ_CP029197|10|2429343-2429447|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGATCGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGCTGCTCTGCCAATTGAGCTACAGGGGAT

>NZ_CP029197|10|10|2429343-2429447|CRISPRCasFinder
TGCTCTGCCAATTGAGCTACAGGGGAT	CGCGCTCCCCCGACTGGACTCGAACCAGTAACCTGCCGGTTAACAGCCGGC
TGCTCTGCCAATTGAGCTACAGGGGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015033449.1\|2424373_2425792_+\|DUF2252-domain-containing-protein	unknown	unknown	gnl\|CDD\|313268
NZ_CP029197.1\|WP_015033444.1\|2418768_2420367_+\|terpene-cyclase/mutase-family-protein	unknown	unknown	gnl\|CDD\|238362
NZ_CP029197.1\|WP_015033461.1\|2439485_2440748_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|170080
NZ_CP029197.1\|WP_106433837.1\|2435181_2436405_+\|TerD-family-protein	unknown	unknown	gnl\|CDD\|132992
NZ_CP029197.1\|WP_015033454.1\|2429616_2429928_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033457.1\|2433204_2435130_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP029197.1\|WP_015033455.1\|2429957_2431397_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|198375
NZ_CP029197.1\|WP_015033451.1\|2426344_2427022_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378566
NZ_CP029197.1\|WP_041662359.1\|2423882_2424338_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033462.1\|2440889_2442209_-\|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl\|CDD\|235098
NZ_CP029197.1\|WP_015033443.1\|2418195_2418723_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|185291
NZ_CP029197.1\|WP_015033456.1\|2431471_2433205_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP029197.1\|WP_015033447.1\|2421607_2423662_+\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NZ_CP029197.1\|WP_106433836.1\|2425898_2426303_+\|SHOCT-domain-containing-protein	unknown	unknown	gnl\|CDD\|378276
NZ_CP029197.1\|WP_041663846.1\|2436412_2437363_-\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NZ_CP029197.1\|WP_015033446.1\|2420954_2421371_+\|organic-hydroperoxide-resistance-protein	unknown	unknown	gnl\|CDD\|274649
NZ_CP029197.1\|WP_015033452.1\|2427104_2427515_+\|amphi-Trp-domain-containing-protein	unknown	unknown	gnl\|CDD\|275149
NZ_CP029197.1\|WP_015033463.1\|2442244_2443009_-\|sirohydrochlorin-chelatase	unknown	unknown	gnl\|CDD\|225049
NZ_CP029197.1\|WP_015033460.1\|2437570_2439463_-\|DNA-primase	unknown	unknown	gnl\|CDD\|235551
NZ_CP029197.1\|WP_015033445.1\|2420363_2420846_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015033449.1\|2424373_2425792_+\|DUF2252-domain-containing-protein	gnl\|CDD\|313268	pfam10009, DUF2252, Uncharacterized protein conserved in bacteria (DUF2252). This domain, found in various hypothetical bacterial proteins, has no known function.	1.85953e-168
NZ_CP029197.1\|WP_015033444.1\|2418768_2420367_+\|terpene-cyclase/mutase-family-protein	gnl\|CDD\|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	1.25176e-18
NZ_CP029197.1\|WP_015033461.1\|2439485_2440748_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	3.55808e-72
NZ_CP029197.1\|WP_106433837.1\|2435181_2436405_+\|TerD-family-protein	gnl\|CDD\|132992	cd06974, TerD_like, Uncharacterized proteins involved in stress response, similar to tellurium resistance terD. Tellurium resistance terD like proteins. This family is composed of uncharacterized proteins involved in stress response, such as the tellurium resistance proteins, chemical-damaging agent resistance proteins, and general stress proteins from a variety of organisms. The tellurium resistance proteins are homologous terA,-D,-E,-F,-Z,-X gene products, which confer tellurium resistance mediated by plasmids. Currently, the biochemical mechanism of tellurium resistance remains unknown. The family also contains several ter gene homologues, YceC, YceD, YceE, for which there is no clear evidence for any involvement in the tellurium resistance. A putative cAMP-binding protin CABP1 shows a significant similarity to the terD protein and is also included in this family.	4.07518e-23
NZ_CP029197.1\|WP_015033457.1\|2433204_2435130_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP029197.1\|WP_015033455.1\|2429957_2431397_+\|sugar-kinase	gnl\|CDD\|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	5.19224e-120
NZ_CP029197.1\|WP_015033451.1\|2426344_2427022_+\|hypothetical-protein	gnl\|CDD\|378566	pfam11139, SfLAP, Sap, sulfolipid-1-addressing protein. SAP is a transmembrane transport protein with six predicted transmembrane helices, with a hydrophilic domain between helices 3 and 4. This hyrodphobic region is highly variable among identified Gap-like (GPL, peptidoglycolipid, addressing protein) proteins and may be involved in substrate recognition. SAP also belongs to the LysE protein superfamily (pfam01810), whose members have been implicated in small molecule transport in bacteria. Other Gap proteins export metabolites across the cell membrane so it is possible that Sap specifically may be involved in transport of sulfolipid-1 across the membrane.	1.65388e-21
NZ_CP029197.1\|WP_015033462.1\|2440889_2442209_-\|deoxyguanosinetriphosphate-triphosphohydrolase	gnl\|CDD\|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP029197.1\|WP_015033443.1\|2418195_2418723_+\|NUDIX-domain-containing-protein	gnl\|CDD\|185291	PRK15393, PRK15393, NUDIX hydrolase YfcD; Provisional.	3.84416e-15
NZ_CP029197.1\|WP_015033456.1\|2431471_2433205_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.20989e-164
NZ_CP029197.1\|WP_015033447.1\|2421607_2423662_+\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NZ_CP029197.1\|WP_106433836.1\|2425898_2426303_+\|SHOCT-domain-containing-protein	gnl\|CDD\|378276	pfam09851, SHOCT, Short C-terminal domain.	3e-05
NZ_CP029197.1\|WP_041663846.1\|2436412_2437363_-\|RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	9.87636e-163
NZ_CP029197.1\|WP_015033446.1\|2420954_2421371_+\|organic-hydroperoxide-resistance-protein	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	4.37991e-60
NZ_CP029197.1\|WP_015033452.1\|2427104_2427515_+\|amphi-Trp-domain-containing-protein	gnl\|CDD\|275149	TIGR04354, conserved_hypothetical_protein, amphi-Trp domain. This domain usually comprises most of the span of bacterial or archaeal proteins with a length of about 90 amino acids. Some members, however, are extended by one or two copies of domain pfam07411 in the C-terminal region. No residue in this domain is invariant. A striking feature of this domain is a C-terminal region that alternates strongly charged with strongly hydrophobic residues and usually ends with a Trp residue, e.g. LEIEIEW or FEIKVRW, suggesting an amphipathic beta strand structure. We suggest the name amphi-Trp for this domain. Some members of this function occur regularly in genomic contexts that include putative kinases of unknown specificity related to (but distinct from) HPr kinase, a Ser-specific protein kinase. The function is unknown.	3.03958e-14
NZ_CP029197.1\|WP_015033463.1\|2442244_2443009_-\|sirohydrochlorin-chelatase	gnl\|CDD\|225049	COG2138, COG2138, Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism].	3.23543e-29
NZ_CP029197.1\|WP_015033460.1\|2437570_2439463_-\|DNA-primase	gnl\|CDD\|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP029197.1\|WP_015033445.1\|2420363_2420846_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.04064e-23

>NZ_CP029197.1|WP_015033452.1|2427104_2427515_+|amphi-Trp-domain-containing-protein
MKDLKFEQKRSMTRLEAADQLAALAAALREGGDVELEYGQGTLSLSIPEELRSEVEVEVGNGEIELEIEFKWPTARARKARESGREEPAPEPEPAKAPPRRKSAPARTARTAAGTKRTAAGTKKTAGSRPPAAKKS
>NZ_CP029197.1|WP_015033451.1|2426344_2427022_+|hypothetical-protein
MVLDLFLIGLAIALYPLPGMALVLVLSSPRGVYKGLAFITAWLACLVAVIALVLLCTGGEPPAPRSPPSLASLAATLVIGLSLVVYSEHRRRRSRRVTAASDDGEGTAGSGRSPASRMDQATGWSAAGLAVLLQPWGMVSAAAATVVKADASHAQSFLALLGFCVLATSTLLAMELYTVFAPEDAQRDLTRLRAWLSRHKDQAIVLLCLLLGLWLVGRSLYQLTG
>NZ_CP029197.1|WP_106433836.1|2425898_2426303_+|SHOCT-domain-containing-protein
MVNLAVDYPLLNMFWTMLMLFLWILWFMLLFRIIGDIFRDDDLNGWGKAGWSAFVILLPFLGVFVYLIARGRSMGERELKRIRQNEEQFRSYVRETTGSGGGQAEELSRLAELKNSGAITEAEFTQAKAKVLAS
>NZ_CP029197.1|WP_015033449.1|2424373_2425792_+|DUF2252-domain-containing-protein
MPRKVTTALRAAHHATPEERAALGRKARRRSPRSGHAEYRPSADRPGPLTILEAQSATRVPELVPIRYGRMTESPFRFYRGAAAIMASDLAGTPRSGLTAQLCGDAHMLNFRLLASPERQLMFDINDFDETLPGPWEWDVKRLAASLVIAARANGFDDAERARIVRRTVRAYREAMIRFAGMRTIDVWYAKIDAARLEALTKDLLAKRGRKDLSRALAKARTRDSLQAFDRLTRTVDGRPVIAADPPLLVPVSDLLPELRRTALERQFRGLIERYGATLPSDRRTLLADYRLADVARKVVGVGSVGTRCWIFLLLGRDNRDPLFLQAKEADTSVLAPYAGASAYRNQGERVVSGQRLMQATSDILLGWERVDGIDGRRRDFYVRQLRDWKGIAEPERMLPRGMGAFGDMCGLTLARAHARSGDRIAIAAYLGRGDSFDRALARFAEAYADQNERDHRALVDAVRAGRLPGVR
>NZ_CP029197.1|WP_041662359.1|2423882_2424338_+|hypothetical-protein
MSQHTPTGGQGSAGTAPGRAHRPGGGGVAGGGTVFAAVLLSVSGVLAVLQGIAAIAEDDVYARVGSYVFEFDLTSWGWIHLILGIFVALTGVGLFKGANWARAAGICLAGLSMIANFLWLPYQPWWALTLMAINVFIIWALCASWSRTTAG
>NZ_CP029197.1|WP_015033447.1|2421607_2423662_+|phospholipase-C,-phosphocholine-specific
MADLDRRRFLQLAGGAAAFTMLSESVARAAAIPAQGSTGTIQDIEHIVVLMQENRSFDHYFGAMKGVRGFGDPRPVTLPSGKSVWNQSDGSKVTLPFRPTSDKLGMEYLQGLNHDWAGGQSAFNKGKYDNWVPAKTKATMAHLTREDIPFHYALADAFTICDAYHCSFIGATDPNRYYMWTGYVGNDGKGGGPVLNNAEAGYGWTTYPERLEAAGVSWKIYQDIGDGLNAAGSWGWINDAFRGNYGDNSLLYFNNYRNAQPGNPLYDKARTGTNAKAGEGFFDILRADVQGGRLPKVSWIAAPEAFSEHANWPSNYGAWYIAQVLDALTSNPDVWARTALFITYDENDGFFDHVVPPYAPGSAAQGLSTAPTALDYFGGKTGYVAGPYGLGPRVPMIVVSPWSTGGYTCSETFDHTSVIRFMEQRFGVTEPQISPWRRAVCGDLTSAFDFSRTDTSAAPLPPVAGYYPPDKNRHPDFLATAPASGTMPRQERGAKPTRPLKYAPYVDGAADIAAGKFRLTFSGGPAAGAQFYVTSANRTDAPWTYTAEAAKSISDTWNTTYSKGVTDLTVHGPNGFVRRFRSPGKTAVPEVTARHNATTGQLDLTFTNAGTTATVTLTNAYGGTPATLTVAKGATVTRAVDVSAAHRWYDITVTSSASTDYVRRLAGHVETGAPSQSDPAILTY
>NZ_CP029197.1|WP_015033446.1|2420954_2421371_+|organic-hydroperoxide-resistance-protein
MDAIYTAVATANGREGRAVSSDGHIDLPLAHPQALGGNGQGTNPEQLFAAGYAACFASAMNLVARQEKIDITDASITAEVSIGKDPADGGFGLSVVMRAEFPDHLQGAAGAALLEKTHAFCPYSKATRGNIKVDLVVE
>NZ_CP029197.1|WP_015033445.1|2420363_2420846_-|MarR-family-transcriptional-regulator
METLDTAPDEDFLRLDDQICFSLHAATRAFNGVYREALKDLGITYPQYLVMLVLWEHGELPVKGIGERVRLDSGTLSPLLKRLEAAGYVERRRSPEDERSVTVRPTAEGTALREKARGVPRRIAAATGLELGELRDLRERLDALAVRLGGVDPDDLNTCR
>NZ_CP029197.1|WP_015033444.1|2418768_2420367_+|terpene-cyclase/mutase-family-protein
MTYCAPPLPGASLAAPGAGRPSADGLDHARARLATRLVAAAAPDGLLRAPCESRVLESALALRLLTVTGVDPDAQERLTRRLKTALDEGGTDPVQEAAARAALGEYVDGPAALARLLDGFDHFTAGRKRLMFQTVLAELGAHPYPELRSPGDVFEARGQQRWLVTEMAALKVLHAFGTGSPRLVAEADWRALAPCARPGPPPYGNHLVRTLGLLALRHSTRHAAAVAARARELRAGLREDGGLPYITGLDVFATALGGLALAGAGASALTLRALATALTERQNADGGWGFDRGVAQSDVDDTSYCVEFLRAAAPERCGAEVAAGERYLLSRAGADGGFPTFEPGTASEVAITAAAVNALAPVPAHRSVVEAGVRFLVDRQGAAGPVERSWSLNESNALFRTVLAYDSCRAAVPGGPAAAGAGRARARAVARLLATRNEDGGWGHVPSDPSDPISTAYALIAVARTPAEPAAVAATERAVRYLLDRQRPDGGFVSRPDQAGPRPFAYHVPLLTDVCVLLGLNHAAAARGRAGA
>NZ_CP029197.1|WP_015033443.1|2418195_2418723_+|NUDIX-domain-containing-protein
MRLRCVVMQTRRVTHEQVDHVDPGDRVVAQGRRTDAPPAGLLRRYAATVCSDHAGRVLLYRRTPTVRTYPDHYDVLVGGAVRTGEEYLAAALRELREELGWTAAPGIAEAYRVRVDDPHGACFLTVHRWVADRPPRPDPREIAWCGFVAPLTVMTGGYTPMVPAGAEAVRRLFPL
>NZ_CP029197.1|WP_015033454.1|2429616_2429928_+|hypothetical-protein
MRYKLTFVVGLALGYVVGTRAGRERYEQMKKSAKDLARNPAVRNAAESAAQTGRQVAGKAAHVVGDKVGDRLPSSVTDRFHALSGRGGANGKVEEDDWGTSNT
>NZ_CP029197.1|WP_015033455.1|2429957_2431397_+|sugar-kinase
MGIVAGLDSSAEFTRIVVCDTDTGAVLRQGYAPHPGEPKAVDVDPQTWLLSLGEAATGGLLEGVQAIGVSAQQHGLVPLDAQGGLVRPALVRNDKRAQVAAADLVESLGGRQAWAEAVGSVPGAGQPVAKLRWLARTEPEHAARVAMILQPHDWLVWQLLGRPARRTTDRGAASGTGYWSARTGSYRPDLVELALGHQAVLPEVLGPAEAAGTTPEGLLISAGTGETMAAALGLGLGPGDAVVSLGASGSVMAVHHEALSDPRGMITSFADATGMHLPVVHTSNAVRTLRGTAEMLGVESLEELSALALKSTPGASGLVLLPYLEGERTPSLPHSAGTLSGLRRESMKPEHLARASFEGMLCGLTDAMDVLRGRGVEVRRVFLLGAAAALPAVQALAPALFGAQVVVPQPADYAALGAARQAAWALGVARGTLSPSAPLAWQGAAAQILEPGEDLAAGQAVRQQYVATRDQLHPGAFAS
>NZ_CP029197.1|WP_015033456.1|2431471_2433205_+|ABC-transporter-ATP-binding-protein
MLIRLLRTHLGPYRKPIALLVFLQFLQTCASLYLPTLNADIIDNGVVDGDTGYILRFGALMVGVSVVQVVCNVGAVFYGARTASALGRDVRAAVFDRVQSFSARELGHFGAPSLITRTTNDVQQIQMLVLMAFTLMVSAPIMCVGGIVMALGQDVPLSGVLLAVVPVLGVSVSLIVRRMRPLFRTMQERLDTVNRVLREQITGNRVIRAFVKDGYEEERFRGANAQLTDVSMATGRLMALMFPVVMTVVNISSVAVVWFGAHRIDSGGMQIGALTAFLAYLMQIVMAVMMATFMFMMVPRAEVCAERIEEVLATETSVVPPVKPVTKLDRRGHLEVRSADFRYPGAEESVLKDVGLVARPGETTAIIGSTGSGKSTLLGLVPRLFDATGGEVLVDGVDVRELDPRLMAKTVGLVPQKPYLFSGTVATNLRYGKPDATDEELWHALEVAQAADFVRNLEHGLNSPIAQGGTNVSGGQRQRLAIARTLVQRPEIYLFDDSFSALDYETDALLRAALAEETADSTVVIVAQRVSTIRDADRIVVLDEGRVVGTGRHQELMADNETYREIVLSQLTEAEAA
>NZ_CP029197.1|WP_015033457.1|2433204_2435130_+|ABC-transporter-ATP-binding-protein
MAGPGGRMMAGGGPDQRSMDFKGSGKRLLKQLAPERGALWVMLLAGVLSVAASVIGPKILGRATDLVFAGVIGRQIEGGTKPEAIERLRAAGDSGMADMLSGVDFTPGQGIDFSAVGGVLLLVLGVYVAAGLLMLVSTRMSIKVINRTVYRMREDVQTKLARLPLSYFDKAKRGEVLSRATNDIDNISQTLQQSMGQLINSLLTIVGVLAMMFWISPLLALVALITVPVSVFVAAKIGKRSQPHFVQQWKSTGALNAHVEEMYSGHNLVKVFGRQEESARDFREQNEALYEAGFKAQFNSGVMQPVMFFISNINYVLVAVVGGLRVASGTLSIGDVQAFIQYSRQFSMPLTQVASMANLVQSGVASAERIFELLDAEEQEPDAPTGEKVADLKGKVALEGVSFRYEADKPLIEDLSLTVEPGQTVAIVGPTGAGKTTLVNLLMRFYEVTGGRITLDGVDIAGMSREQLRAGIGMVLQDTWLFGGTIADNIAYGATREVTRAEIEEAARAAHADRFVRTLPEGYDTVIDDEGAGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKAMARLAHGRTSFVIAHRLSTIRDADVILVMENGSIVEQGTHEELLASGGAYSRLYAAQFAQAVAEVD
>NZ_CP029197.1|WP_106433837.1|2435181_2436405_+|TerD-family-protein
MAKSSWVPSVTLRVGAGGVDVAALLLAADGRVRGDADMVFDGQPAHPSGAVRHEQASLLLALHEVEADVERIVIAGSAAGGALTAVAPDGAAVAAHTVAAAPETTAVVLAEFFRESGGWKFAGGGKGYGSGLAALVTEFGVEVADETGAAQQQPEPVAAGPVPLTGVVKMPVRARQAGGSSAAGAAAPGHAGPSAPGGPFPPADRPYELVGGWEFGPVFEPFAITGDGDQVVTVDDRVPPGPVLVETAHEGRDGYFAVFPLDQRNKDGQYLFSTTLPDFRGSSVTPAPEGRALRLRVRAYHRWVMRVKPVAAARRIEGTLRGYGPEALLYTGGAADLQVHFEGDEDGGGYVGIRCHEVAGHTGLTERPTLLLNRTEPLLHTVPLPPGPLLLLHRADGPWTLTVKELD
>NZ_CP029197.1|WP_041663846.1|2436412_2437363_-|RNA-polymerase-sigma-factor
MPPQRRRPDLGGNGPSSDLFRQYLREIGRIPLLTAEEEVDLARRVEAGLFAEEKLANTPDLDSRLASDLDRLVVLGRIAKRKLIEANLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYARGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVIRVQRRMLQERGYEPTAEEVAAQLDLAPERVGEVLRLAQEPVSLHAPVGEEEDVALGDLIEDGDAASPVESAAFLLLRRHLEDVLSTLGERERKVVQLRYGLDDGRPRTLEEIGRIFGVTRERIRQIESKTLGKLRDHAYADQLRGYLD
>NZ_CP029197.1|WP_015033460.1|2437570_2439463_-|DNA-primase
MAGRINDDDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPSKGLFHCFGCQEGGDTIAFVMKIDHLSFSETVERLAAKAGITLRYEEGGYNPGHQRGERIRLIEAHKVAAQFYADQLGSPEAEIGRAFLAERGFDQAAAAHFGVGYSPAGWDHLTRYLRGKGFSDKELILSGLSQDGRRGPIDRFRGRLMWPIKDVGGEIVGFGARKLRDDDNGPKYLNTPETPIYKKSQVLYGIDLAKKDIAKVSRAVVVEGYTDVMACHLAGVTTAIATCGTAFGGDHIKILRRLLMDNGSARVIFTFDGDSAGQKAALRAFEDDQKFAAETYIAIAPDGMDPCDLRLAKGDEAVVDLVQPRTPLFEFALRQIVKRYDLETPAGRAAALDEAAPVVARIKNIGAQHEVAVQLAGMLGILDTQFVVKRVAQLARWARDRGGKGPERQQGPQRGYDTAAPAPAPSGPALNLRSPAHRTERELLKLALQRPELVSPAFDAYGVDEFTAPPYAAVRQCVQDAGGATGAPADYLDAVREAAPNDTVRALVTELAVETIFAKTVDEAYAGDQLVTVRLRAVDRRIRDVQGTLARLGAQGDPEQLAAVQNELWVLTQYGQSLRNNGAAAL
>NZ_CP029197.1|WP_015033461.1|2439485_2440748_-|FAD-dependent-oxidoreductase
MVDADQTFVIVGGGLAGAKAAETLRAEGFNGRVILIGDERDYPYERPPLSKGYLTGAKERDSAFVHEAAWYARHDIELHLGQSVTAVDREAHTVRLGDGTVIRYDKLLLATGAEPRRLDIPGTELAGVHHLRRLAHADRLRQVLASLGRDNGHLVIAGAGWIGLEVAAAARGYGAEVTVVESDPTPLHRVLGPELGQLFADLHTDHGVRFHFGARFTEIVGQDGMVLAVRTDDGEEHPAHAVLAAIGAAPRTALAENSGLALVDRADGGGIAVDESLRTSDPDVFAAGDVAAAHHPLLHTRLRVEHWANALNGGPAAARAMLGQHVSYDRVPYFFSDQYDLGMEYSGWAPPGSYDQVVVRGDTGKREFIAFWLKEGRVLAGMNVNVWDVTDPVQQLIRARKPVDPDALADASVPLESLIA
>NZ_CP029197.1|WP_015033462.1|2440889_2442209_-|deoxyguanosinetriphosphate-triphosphohydrolase
MEGITDTSGQDTPADTPGYDSAATERWDTEPDKRPGRTAFQRDRARVLHSAALRRLAGKTQVVTPGTRGHAWDASPRTRLTHSLECAQVGRELGAALGCDPDLVEAACLSHDMGHPPFGHNGEQALNDVAKDCGGFEGNAQSLRLLTRIEPKRFVKDADGELVSVGLNLTRAALDAATKYPWPRGAHPEDPGSPKFGVYEDDLPVFAWIREGAPAHRKCFEAQVMDWSDDVAYSVHDFEDGLHAGHIDPNLLLAEPERADIAAVAIGRYVPEDTDPQELAEALDRLVDQEWWPHGYDGSAVAQARLKDATSQLIGRFCLAAEGATRQAYGSGGLTRYGAELVVPREARNECAVLKAVADRYVMQRPQQEALRADQRIVVAELAEALVARAPDGLEPQFRSLFDAARDDRARKRVIVDQIASLTDASARALHAALRPHHS
>NZ_CP029197.1|WP_015033463.1|2442244_2443009_-|sirohydrochlorin-chelatase
MTEPHTPRRRPTLVAVGHGSRDPRARATLSRLLDRVRELRPGLDVRLAHIELNAPLLDATLAELAAEGRDAVLVPLLLAPGHHVTHDLPAALAAVPALRARLAAPLGAHPLLVEALADRLAQAGWPPGDGDSPATGIVLASAGSRDPRSGAETRRIAALLGERLGGVPVLPAYASAAAPTVPEAVRVLTARGRHRIAVASCFTAPGLFATRAAAHAPWIASDPLGAHPALARLVLHRYDTAPRPTTRGRELATV

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Crispr_ID: NZ_CP029197_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_11

2534402-2534542

Orphan

Consensus_repeat	Method
ACCAGGGCACCGCCCGGAAACTCACCGCCCCAACCCCGGAAGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_11

>merge|NZ_CP029197|11|2534402-2534542|CRISPRCasFinder
ACCAGGGCACCGCCCGGAAACTCACCGCCCCAACCCCGGAAGGGGGTCAGGGCACAGCCCCGGGAGGGGGTCGGGGCGCAGCCCCCGGCGGGGCCACCAAGGCACCGCCCGGAAACTCACCGCCCCAACCCCGGAAGGGGG

>NZ_CP029197|11|11|2534402-2534542|CRISPRCasFinder
ACCAGGGCACCGCCCGGAAACTCACCGCCCCAACCCCGGAAGGGGG	TCAGGGCACAGCCCCGGGAGGGGGTCGGGGCGCAGCCCCCGGCGGGGCC
ACCAAGGCACCGCCCGGAAACTCACCGCCCCAACCCCGGAAGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015033544.1\|2529401_2531279_-\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|223953
NZ_CP029197.1\|WP_030317512.1\|2533522_2533789_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
NZ_CP029197.1\|WP_015033540.1\|2522740_2523541_+\|DUF3097-domain-containing-protein	unknown	unknown	gnl\|CDD\|378628
NZ_CP029197.1\|WP_015033550.1\|2537393_2538239_-\|arylamine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366312
NZ_CP029197.1\|WP_106433839.1\|2524729_2527933_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|366375
NZ_CP029197.1\|WP_015033537.1\|2519694_2520831_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|237654
NZ_CP029197.1\|WP_078508874.1\|2540226_2542836_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|225212
NZ_CP029197.1\|WP_015033551.1\|2538277_2539549_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP029197.1\|WP_015033539.1\|2522001_2522730_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293840
NZ_CP029197.1\|WP_041662379.1\|2536087_2536330_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015033549.1\|2536383_2537274_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377274
NZ_CP029197.1\|WP_015033547.1\|2535021_2536011_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
NZ_CP029197.1\|WP_015033538.1\|2520831_2521851_-\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP029197.1\|WP_015033545.1\|2531474_2533340_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_CP029197.1\|WP_015033536.1\|2518480_2519560_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|367316
NZ_CP029197.1\|WP_041662377.1\|2528078_2529320_-\|coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180172
NZ_CP029197.1\|WP_015033555.1\|2544123_2544969_-\|DegV-family-protein	unknown	unknown	gnl\|CDD\|273257
NZ_CP029197.1\|WP_015033552.1\|2539545_2540169_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378968
NZ_CP029197.1\|WP_041662380.1\|2545048_2545795_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_071892433.1\|2542985_2544032_-\|ComEA-family-DNA-binding-protein	unknown	unknown	gnl\|CDD\|224472

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015033544.1\|2529401_2531279_-\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	0
NZ_CP029197.1\|WP_030317512.1\|2533522_2533789_+\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	4.23035e-22
NZ_CP029197.1\|WP_015033540.1\|2522740_2523541_+\|DUF3097-domain-containing-protein	gnl\|CDD\|378628	pfam11296, DUF3097, Protein of unknown function (DUF3097). This family of proteins with unknown function appears to be restricted to Actinobacteria.	3.02447e-162
NZ_CP029197.1\|WP_015033550.1\|2537393_2538239_-\|arylamine-N-acetyltransferase	gnl\|CDD\|366312	pfam00797, Acetyltransf_2, N-acetyltransferase. Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	3.86398e-83
NZ_CP029197.1\|WP_106433839.1\|2524729_2527933_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|366375	pfam00931, NB-ARC, NB-ARC domain.	1.36564e-10
NZ_CP029197.1\|WP_015033537.1\|2519694_2520831_-\|molecular-chaperone-DnaJ	gnl\|CDD\|237654	PRK14278, PRK14278, chaperone protein DnaJ; Provisional.	0
NZ_CP029197.1\|WP_078508874.1\|2540226_2542836_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|225212	COG2333, ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only].	2.84024e-42
NZ_CP029197.1\|WP_015033551.1\|2538277_2539549_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.01891e-55
NZ_CP029197.1\|WP_015033539.1\|2522001_2522730_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.7774e-46
NZ_CP029197.1\|WP_015033549.1\|2536383_2537274_-\|hypothetical-protein	gnl\|CDD\|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	2.60896e-49
NZ_CP029197.1\|WP_015033547.1\|2535021_2536011_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	1.84542e-89
NZ_CP029197.1\|WP_015033538.1\|2520831_2521851_-\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	1.92599e-157
NZ_CP029197.1\|WP_015033545.1\|2531474_2533340_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_CP029197.1\|WP_015033536.1\|2518480_2519560_-\|nitronate-monooxygenase	gnl\|CDD\|367316	pfam03060, NMO, Nitronate monooxygenase. Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase, but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.	3.81019e-111
NZ_CP029197.1\|WP_041662377.1\|2528078_2529320_-\|coproporphyrinogen-III-oxidase	gnl\|CDD\|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	0
NZ_CP029197.1\|WP_015033555.1\|2544123_2544969_-\|DegV-family-protein	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	6.53731e-104
NZ_CP029197.1\|WP_015033552.1\|2539545_2540169_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	3.125e-10
NZ_CP029197.1\|WP_071892433.1\|2542985_2544032_-\|ComEA-family-DNA-binding-protein	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	2.72983e-20

>NZ_CP029197.1|WP_030317512.1|2533522_2533789_+|30S-ribosomal-protein-S20
MANIKSQIKRNKTNEKARLRNKAVKSSLKTAIRKAREAVAAGDVEKATVASRAASRALDKAVSKGVIHKNAAANKKSALATKVAALQG
>NZ_CP029197.1|WP_015033545.1|2531474_2533340_-|elongation-factor-4
MPATPTNVPEPSRTDPALIRNFCIIAHIDHGKSTLADRMLQLTGVVDQRQMRAQYLDRMDIERERGITIKSQAVRLPWAPTEGPAQGDTHILNMIDTPGHVDFTYEVSRSLAACEGTILLVDAAQGIEAQTLANLYLAMENDLTIVPVLNKIDLPAAQPEKFSEELANLIGCQPEDVLKVSAKTGMGVEALLDRVVRDVPAPVGVADAPARAMIFDSVYDSYRGVVTYVRVVDGQLNKRERIRMMSTGATHELLEIGVSSPEMTSSDGLGVGEVGYIITGVKDVRQSKVGDTITSLHQGATEALGGYKDPKPMVFSGLYPLDGSEYPDLREALDKLQLNDAALVYEPETSAALGFGFRVGFLGLLHLDVIRERLEREFGLDLIATAPNVVYRVVMEDGSEHTVTNPSEFPEGKINDVYEPVVRATILAPSEFIGAIMELCQTRRGTLIGMDYLSEDRVEIRYTLPLAEIVFDFFDQLKSKTRGYASLDYEPTGEQASSLVKVDILLHGDKVDAFSAVTHKDAAYAYGVRLVAKLRELIPRQAFEVPIQAAIGSRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGSVEVPQEAFIAVLSSDESGGKKK
>NZ_CP029197.1|WP_015033544.1|2529401_2531279_-|long-chain-fatty-acid--CoA-ligase
MSDTQTQIENRPPSVATLFLERVERTPDAEAYRYPVPAASGAGPDDWKSLSWGQAAERVYAIAAGLVDLGVASEERVALASATRVEWILADLGVMCAGAATTTVYPQTNAEESAFILSDSESRVLIAEDAAQLAKAVERRADLPNLRHVVVIDATGVESDGDFVLTLAELEARGKGYLEKHPEAVKERVAAITATQLATLIYTSGTTGRPKGVRLPHDNWSYMAKAIAATGLVTQADVQYLWLPLAHVFGKVLTSGQIEVGHVTAVDGRVDKIIENLPVVQPTYMAAVPRIFEKVYNGVAAKARAGGGAKYKIFQWAAGVAREYAKATQDNFRRTGTATAPFGLTAKHKVADALVYAKIREAFGGNLRACISGSAALAPEIGYFFAGAGIHILEGYGLTETSAASFVNPGEAYRTGTVGKPLPGTEVRIADDGEILLRGPGIMEGYHGLPEKTTEVLESDGWFHTGDIGELSADGYLRITDRKKDLIKTSGGKYIAPAEVEGQFKAVCPFVSNILVHGADRNFCTALIALDEPTLLGWAAEHGLGGKPYAEIVAAPQTVAMVQGYVDRLNEGLQRWQTIKKFRLLPRDLDIEHGELTPSLKLKRPVVEREYKGLIEEMYAGSRES
>NZ_CP029197.1|WP_041662377.1|2528078_2529320_-|coproporphyrinogen-III-oxidase
MGLMPSVLPDGETVPDDGALPPHALEGAGERPLGFYLHVPYCATRCGYCDFNTYTANELRGTGGVLASRDNYAEQVTEEIRLARKVLGDDPRPVRTVFVGGGTPTLLAAGDLVRMLAAVRDEFGLADDAEVTTEANPESVNPAYLAELREGGFNRISFGMQSAKQHVLKILDRTHTPGRPEACVAEARAAGFEHVNLDLIYGTPGETDDDWRASLDAAIGAGPDHVSAYALIVEEGTQLARRIRRGEVPMTDDDVHADRYLIAEDVLSRSGFDWYEVSNWATSEAGRCLHNELYWRGADWWGAGPGAHSHMGGVRWWNVKHPGAYAAALAGGKSPGAGRELLSDEDRRVERILLELRLKEGVELSLLKPAGLAAAAKALTDGLLAPGPYETGRAVLTLRGRLLADAVVRDLVD
>NZ_CP029197.1|WP_106433839.1|2524729_2527933_+|tetratricopeptide-repeat-protein
MGDGPAPGPEPGSRRETDPEAQPQTATPPPSRSRPQTATPLLAHPETQTQPQPQPQPDVPQPDVPPSPLPSPRTAPASHVTVVFAAPQRPWGTWIAHRLERHGHRATLQRWDPPREVPLEQVLRDLLLARGQILFVLDEWFFDRGARQAGEWNEVLRGFVAAHPDRFAAVDLSSRTLPPSAAVLEPVSLWGVDEAEAGARLTHRLALAGNRDGARRHRGATPARFPADPPAVWGAVPRRNPWFSGRDDLLGALQQRLAEGGHGSAACALIGMSGIGKTQIATEYAYRFSPDYDVIWWVHSEDRNSQRDRLGDLAVELGLRVGGEPGERVRAVREALRRGDPHARWLVVFDGWDDTDGIDVMLPQGPGHVLITSRNRGWREHTDVLEIPGFDRRESTGYLMRRAPQINAAEADEVAAEFGDVPLPLAQAAAWLGESGTEAAEYLRMVRDGRLSTVDEPSPDNATLHVSLSSWRILIDRLRRSHPQALQVLSLCSAFAPGPVPLGLLRAGPAARLPADLRWITTDPAAWTRALDTLVNYSVLVRTPGPSAGGKAAGPEEESVHMHRLVHDIVARLTDDEVRYAQLKAVRDLLAEAEPGDPADSGHWPRYSVLLPHLEPSGALRSTAPRVQEAVLNCLRFCDRSGDYRAGLLLARRVRQNWGEFMDRADGRMLALASLEADLLRAAGRFQEAYEQSERTLGQLKANPHDELAELTARSAVANGLRHQGRYHDAHHIQREVLDRTVRLVGTDDPLVLAARHDLAATLRALGRYREAYENDLMTLARREELLGGHHLAGLASANAVTRGQRLLGMYGAALSRQAEVARRHEEALGARHPRTLDADIELALCRRHGDPGGPDGGSSIAGLVDRSVEIHGREHPVTLQCLSLHADALREQGDLGRARALGAEAETGYRALLGPAHPVSLGAVANTALVLLDSGQQSAAVAMLESARAGLIPALGQDHPWVLGCDLNTAAAYRQEGDLVSAVALSRDALGRAQAVLGAEHPLTLSCQLALAADLRGLPLREDDEALVLEEDAVNRLAAALGPQHPRTLAARRRVRPVWSFEPYVD
>NZ_CP029197.1|WP_015033540.1|2522740_2523541_+|DUF3097-domain-containing-protein
MRSYDPDLTPPWKKTAPVPEVPADRDLVVEEVTTGFCGAVIRCEAGTVTLEDRFGKHRVFPLDPRGFLLEGRVVTLVRPSAGPARPTRTASGSVAVPGARARVARAGRIYVEGRHDAELVERVWGDDLRIEGVVVEYLEGVDDLPAIVAEFAPGPDARLGVLVDHLVPGSKESKIAARVTSPDVLVVGHPYIDVWEAVKPSSVGIRAWPRVPRGQDWKTGVCEALGWPPNTGAAWQHILSKVTSYKDLEPELLGRVEELIDFVTAP
>NZ_CP029197.1|WP_015033539.1|2522001_2522730_+|MBL-fold-metallo-hydrolase
MDVDWEAYGWERLADGVGRRRLPGWDATVGLVLGERAVLLYDTGSSLAEGAELRTQIAGLTGGRRVTHIALSHPHFDHVLGTAAFAGAEVFGAVGSDELLGRAREREALREDAVRQGLDATAAAEAADVLVAPRHVVSGEWTLDLGGRQVLLANVGPGHSGHDLALLVPGSREVVFCGDLVEESGEPQAGPDAIPARWPDALDRLLGLGGEDAVYVPGHGAVVDAPFVRLQREELARRFSVA
>NZ_CP029197.1|WP_015033538.1|2520831_2521851_-|heat-inducible-transcriptional-repressor-HrcA
MLSERRLEVLRAIVQDYVGTEEPVGSKALTERHKLGVSPATVRNDMAVLEEEGFIAQPHTSAGRIPTDKGYRLFVDRLAGVKPLSTPERRAIHNFLDGAVDLDDVVGRTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARLMLVLITDTGRVEQRVIDCPAPFGETSLADLRARLNSRVVGRRFADVPQLVQDLPESFEETEDRATVTTVLATLLETLVEEHEERLMIGGTANLTRFGHDFPLMIRPVLEALEEQVVLLKLLGEAKESGMTVRIGHENAHEGLSSTSVVSVGYGSGGEAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES
>NZ_CP029197.1|WP_015033537.1|2519694_2520831_-|molecular-chaperone-DnaJ
MATDYYAVLGVRRDASQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKKQVYDLGGDPLSASGGGGAGGFGAGGFGNFSDIMDAFFGTASQRGPRSRTRRGQDAMIRLEIDLNEAAFGTTKDIQVDTAVVCTTCSGEGAAPGTSAQTCDMCRGRGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRVRSRRTLTVKIPAGVDNGTRIQLAGEGEVGPGGGPAGDLYVEIHETPHETFQRRGDDLHCTVTIPMTAGALGTKVPLQTLDGVEEIDIRPGTQSGQSIPLHGRGVTHLRGNGRGDLIVHVEVQTPAKLDAEQERLLRELAKLRGEERPTGQFQPGQQGLFSRLKDAFNGR
>NZ_CP029197.1|WP_015033536.1|2518480_2519560_-|nitronate-monooxygenase
MSSTALNDLSRFPIVQAPMAGGASGPELVGAVCSAGALGFLAGGYKTAGGLYQEIKQVRGLTSRPFGVNLFMPQTGRPADPAAVEVYRHQLAGEATWYETPLGETDDGRDDAYDAKLAILLEDPVRVVSFTFGCPTPEVLASFARVGTFTIVTVTSAEEALAAQQAGADAVCVQGAEAGGHQGTYRDDPADDAPGTGLLALIAQVRESVALPIVATGGIMRGAQIAAVLAAGATAAQLGTAFLCCPESGAHPLHKRALTDPLFTRTAFTRAFSGRPARGLVNRFMREHGPYAPAAYPEIHHLTAPIRKAAATAGDAQGMALWAGQGHRLARELPAGQLVEVLAAELDTALSELAHRSAS
>NZ_CP029197.1|WP_015033547.1|2535021_2536011_-|DNA-polymerase-III-subunit-delta
MATRKTSPDDLLGPVTLAVGQEDLLLDRVVQSVVAAARAADADTDVRDLTPDQLQPGSLAELTSPSLFAERKVLVVRNAQDLSADTIKDVKAYLDDPVEDISLVLLHAGGAKGKGLLDAARKAGAREVACPKTTKPAERLTFVRQEFRTLGRSATPEACQALVDSIGSDLRELASAVAQLTSDVDGTIDEAVVGRYYTGRAEASSFNIADRAVEGRTAEALEALRWSLSTGVAPVLVTSALAQGVRAIGKLSSARGGRPADLARELGMPPWKIDRVRQQMRGWTPDGVSLALRAIAEADAGVKGGGDDPEYALEKAVVAVARAARMRRG
>NZ_CP029197.1|WP_041662379.1|2536087_2536330_+|hypothetical-protein
MSERHVLVLPDRDSAEELAGELPDRFGVAEEPQLVRDSLAGEDDAEDAQWLVVVEDPDGRLDAAALDELAAEYEGWLEAP
>NZ_CP029197.1|WP_015033549.1|2536383_2537274_-|hypothetical-protein
MFDRLFGKRPAGAARGGPLAGLSVPASAGVVSCRVLDPVHEPVRRAEFLLSDTVGRKVLAGETDPYGTALATVPAGEYRLAVTAEGYTPHHGSAVVTEGGHTGLGDVLLQIAPQPQLPEPGDWEIDPTHSQIGFTARHIGLARIHGRFNSFAGAVRIADRMERSAMHVVIDAASIDTGVQMRDDHLRSSDFLDVGAYPTLEFYSERFTHKGGSRWAVTGALTLHGVSRTVTLDTQYLGIGSGLEGETRCACRATTELHREDFTLTWQTLLARGIAAVGSSISIDLDVQIVPKVTRG
>NZ_CP029197.1|WP_015033550.1|2537393_2538239_-|arylamine-N-acetyltransferase
MTTRPTAPVPPESFVPTPADVEAYLRRIGAARPDREDSDALRELQLRHLRTVPFENLSIHLGEAVVLDEKALLDKVVGAHRGGFCYEVNTAFAVLLRGLGYEVSLLQARVFGEGGKPGIPYDHMALLVETADGRRRLADVGFGDHSHYPLDFDDRGEQQDPGGVFRIVEGVEGDLDVLRDGKPQYRVERRPRELADFAAGAWYHQTSPDSHFPRSLVCSLLTEDGRITLSDRKLITRAGGEREERTLESEEEVRGAYRELFGIELDVLPVVRGGIPDSNPR
>NZ_CP029197.1|WP_015033551.1|2538277_2539549_-|MFS-transporter
MSRVALVERVPALLRERTFRRYWTGQTVSLAGDQISLMAIPLAAVLVLGADAAAMGWLKAAELLPALLLNLPFGAWADRQASRRRAMIATDLGRAGLVLSLPVAYALDALTLTQLYVVAFGIGALTVLFEVCNTTLFVALVPTERYVQANSLVNGSRSTAWLAGPGVGGLLVQLLTAPFALVADALTYLVSAGYLARIKPVEPPPAPVAKGHFTEGLRWVIRERSMRALFAASGTVQFFNYMFHTLFVIYVTTELGISPGLLGLVLGTGAVGGLLGAVLSGAVVRRIGIGGSLVAGFLGFTLPLVLIPLADGPLPFVVSVLFVAEFLSCVGVMIVDVAAGSFQMALIPDAVRARVMGAFRTLNHGFRPLGALVGGFLGTVIGLRPTLWIATVGAVFAVLWVLASPLARMRELPSPEEESAPVG
>NZ_CP029197.1|WP_015033552.1|2539545_2540169_-|helix-turn-helix-transcriptional-regulator
MQEESSDQRPEGEQPRSIRLTDPRALRAYAHPLRLSLVGLLRSSGPFTATRAAELTGESVASCSYHLRILAKYGLVEEAPGGRGREKPWRATARYTEWPEYSEDAAVAQAAGALTAVVAERYFERVVRAMGNRHRLPKEWQEAEQFGDSLLYLTPEELADLGARIEALLRPYEARESDPSLRPEGAGPVSVLRVAYLDLDVPDREKE
>NZ_CP029197.1|WP_078508874.1|2540226_2542836_-|MBL-fold-metallo-hydrolase
MYGGRGDGPFRDEGPTDLRLVPLAVAAWVAAACALGAPGWWSVAGVTVALVGAAVLWAPAAARWFAGPDRPGEPRPTEGGAEAGTLRRGTPGGRLRATACAGVLLCAAAGATSAGLHAADLRRGPVPALAREYARAQLEVTVTSDPRLTRPRVSGSATVPVSVVLDGEVTRAERPGGAAHRTRAPVLLIVPPGAARDAWLRLLPSTRLEVDARLVPPTQPGDPFAAVLKVDRGPPRIVGRPSALQRTAGELRAGLRRVTDGLDPDARALLPGLVVGDTSRIGTELRDAFQATDLTHLLAVSGSNLSVVLLLLVGRPGRAHEVERGGLAPRIGLSLRGSALAGGALTLAFVVVCRPDPSVLRAAACGLVVLLAIGTGRRRSLIPALATVVLVLVLYDPWLARSYGFLLSVLATGALLTVAPRWSEALRMRGVPDRLAEALAACLAAQAVCAPVVVVFAGRVSLVAIPANLCAELAVAPATVFGFAALALAPVWTPAGEGLAWVAGWPAGWIARVARAGAALPGAEMSWPGGWWGGAALALITVVVVLGARRLPYRGPMALLVAVLLLLVVARPAPLTRWVGGWPPPGWVFAMCQVGQGDATVLAAGGDAAVVVDAGPDPVPVDRCLRELGVRRVPLLLLTHFHADHVAGLPGVLRGRSVGAIQVTGLEEPPAQAAFARRTAAAARVPLIPAGLGERRRVGALEWRVLWPMAGPGAAATGSGAAGGGGEAGGGTGAGDSGGSSGFGGGDGPNDASVTLLVTVAGRLTLLLLGDLEPPAQRALLRAHPDLAPVDVLKVAHHGSAHQDPGLMRAVRPRLALVSTGSGNPYGHPSPRTVESLRAGGARVLRTDLDGAIAVVGAGPGLTAVAGGE
>NZ_CP029197.1|WP_071892433.1|2542985_2544032_-|ComEA-family-DNA-binding-protein
MPTVIRMTLRTRIASTTPGAPSSGPGRAPGSDGRSRPGARGAPPGRARRRSRARRAGTAPETLVRGRGDALFPAAAGTAAASPGEVQGEVTARDGAPGAVGRVSAPPGARERLAVALRERTPVWLQTRCGLEPRALAALTVVLVVAAVLAAGYFWTGRPEPVRAPELVRAAVPAGPAATPAARTGPLTGPAPGPAATGAPKVIVDVGGKVRRPGVLTLPAGSRVADALHAAGGVKPGADLTGLNRARVLFDGEQVLVGLPGAPVGGSGGASGAGAGSGAGGGGPGVPLSLNTATVEQLDTLPGVGPVLARHIVDHRTERGGFRSVGELREVNGIGERRFADLRPLVRP
>NZ_CP029197.1|WP_015033555.1|2544123_2544969_-|DegV-family-protein
MSRHVAIVTDSTAYLPRQTRERHAITTVPLTVVIGDRALEEGTEISAKALAEALQKKRSVTTSRPSPEVFAEAYREAAEAGARSIVSLHLSAEVSGTYDAAVLAAKDAPVPVRVVDTRMMGMALGFCALAAAQVAEAGGSLDEAVAAAEKRAAGTSAFFYVDTLDYLRRGGRIGAAQALLGSALAVKPLLELDGGRIELREKVRTASKAIARLEEIAVERAGSGAVDIAVHHLSAPERAGVLADRLRERLPGMAELHVSEVGAVIGAHTGPGLLAVVVSPR
>NZ_CP029197.1|WP_041662380.1|2545048_2545795_-|hypothetical-protein
MEAAIITIMALLFLSFVALGVFVTVKAVKAAKRGVDRTIDQARRTVEDTTLRAKSFGQAGVTGELARLRLSLRTSMRATQEALHAGVGEDASLKESLDLFHRLSAHGLELDEDLKRLEREPDRAWVAAQLPELTARTERITGSADALRRAARDRALKFAEDDLSALSAQIDVEAGALRHWTTGPETTPEATGTGPGTSRPSSSGNHRPAAAPGNAGPATGGEPSAITAPDPRRTAYPWEKSARPETTT

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Crispr_ID: NZ_CP029197_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_12

3120361-3120535

Orphan

Consensus_repeat	Method
GGGGGACAGTGCCCCTAC	CRT

4 spacers

The CRISPR arrays of NZ_CP029197_12

>merge|NZ_CP029197|12|3120361-3120535|CRT
GGGGGACAGTGCCCCTACCCCCGGCACCGATACCTCGGGGGACAGTGCCCCTACCTCTCAGGGCTCTACCTCGGGGGACAGTGCCCCTAGGTCGGCCGAAGAGGGGTGGGGGGACAGTGCCCCTACTCAGGTAGGGGGACAGTCCCCCGAGGGGGTGGGGGCACAGTGCCCCGAC

>NZ_CP029197|12|1|3120361-3120535|CRT
GGGGGACAGTGCCCCTAC	CCCCGGCACCGATACCTC
GGGGGACAGTGCCCCTAC	CTCTCAGGGCTCTACCTC
GGGGGACAGTGCCCCTAG	GTCGGCCGAAGAGGGGTG
GGGGGACAGTGCCCCTAC	TCAGGTAGGGGGACAGTCCCCCGAGGGGGTG
GGGGCACAGTGCCCCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_051025877.1\|3122301_3123294_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380155
NZ_CP029197.1\|WP_015034052.1\|3121324_3121981_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197715
NZ_CP029197.1\|WP_015034048.1\|3118927_3119212_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368649
NZ_CP029197.1\|WP_015034055.1\|3123290_3123983_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034056.1\|3123979_3124507_+\|HTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|225949
NZ_CP029197.1\|WP_015034057.1\|3124622_3124883_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131098
NZ_CP029197.1\|WP_145953707.1\|3124977_3125160_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034042.1\|3116386_3116629_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034044.1\|3117036_3117528_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034043.1\|3116705_3116930_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034051.1\|3121016_3121328_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034041.1\|3116171_3116390_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP029197.1\|WP_167537156.1\|3122011_3122266_+\|WhiB-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|376791
NZ_CP029197.1\|WP_015034045.1\|3117527_3117902_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_145953706.1\|3118344_3118935_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_078508881.1\|3125548_3125731_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034059.1\|3125156_3125363_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041662475.1\|3119208_3119415_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034046.1\|3117898_3118348_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034049.1\|3119418_3119826_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_051025877.1\|3122301_3123294_+\|hypothetical-protein	gnl\|CDD\|380155	NF012221, MARTX_Nterm, MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin RtxA. This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.	0.00275666
NZ_CP029197.1\|WP_015034052.1\|3121324_3121981_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	5.5843e-05
NZ_CP029197.1\|WP_015034048.1\|3118927_3119212_+\|hypothetical-protein	gnl\|CDD\|368649	pfam05876, Terminase_GpA, Phage terminase large subunit (GpA). This family consists of several phage terminase large subunit proteins as well as related sequences from several bacterial species. The DNA packaging enzyme of bacteriophage lambda, terminase, is a heteromultimer composed of a small subunit, gpNu1, and a large subunit, gpA, products of the Nu1 and A genes, respectively. Terminase is involved in the site-specific binding and cutting of the DNA in the initial stages of packaging. It is now known that gpA is actively involved in late stages of packaging, including DNA translocation, and that this enzyme contains separate functional domains for its early and late packaging activities.	0.00555174
NZ_CP029197.1\|WP_015034041.1\|3116171_3116390_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.55349e-07
NZ_CP029197.1\|WP_167537156.1\|3122011_3122266_+\|WhiB-family-transcriptional-regulator	gnl\|CDD\|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	1.90069e-22
NZ_CP029197.1\|WP_015034056.1\|3123979_3124507_+\|HTH-domain-containing-protein	gnl\|CDD\|225949	COG3415, COG3415, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	2.39469e-05
NZ_CP029197.1\|WP_015034057.1\|3124622_3124883_+\|hypothetical-protein	gnl\|CDD\|131098	TIGR02043, transcriptional_regulator_MerR_family, Zn(II)-responsive transcriptional regulator. This model represents the zinc and cadmium (II) responsive transcriptional activator of the gamma proteobacterial zinc efflux system. This protein is a member of the MerR family of transcriptional activators (pfam00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-Cys-X(8-9)-Cys, as well as a conserved and critical cysteine at the N-terminal end of the dimerization helix. [Regulatory functions, DNA interactions].	0.00546354
NZ_CP029197.1\|WP_015034049.1\|3119418_3119826_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	0.0030038

>NZ_CP029197.1|WP_015034049.1|3119418_3119826_+|MarR-family-transcriptional-regulator
MSTVPTPADVFRRQAHPLIAPGPHDPTLDAPFRALWERGINGSHLYRHTKLVALTLATHADWATGHIADEDQPRMGRLIDLTGLHPGQVVVSLNVLEQRGWIVRDDRRMRWNVASVQLAVPGPIMRRLKKACTTS
>NZ_CP029197.1|WP_041662475.1|3119208_3119415_+|hypothetical-protein
MTRHPFRPCELPGPHGLGRPRLYLVGWRCDRHTPAALAGRPEAPPGPGWPPGNYLDTRTTAPPPHLQE
>NZ_CP029197.1|WP_015034048.1|3118927_3119212_+|hypothetical-protein
MRDALALAVLGLLLLGAATVLVGTVCLTVASGRALRRFFFPRPRVRLVRVVPAPRRYVWVACDTPRCGHLQTPHYPAGPGRVECNHCGTIRPRP
>NZ_CP029197.1|WP_145953706.1|3118344_3118935_+|hypothetical-protein
MMEAPALTLPQLSVQCPDCNSGPGRLCTSHGGTRYRRDTVHQARRAAWATVQTDKARARTARVDSTAARPAVEALPVDTIEHGTPRGYNQHRTRKVPAYQPCRDALNARNRERRAARQGWNGGRVGEPTAPAPVPTGRDCPVSGCGELASAPQPTARMVHVVWPYSREPGRWYCPGPCQAYGLALAEIRAIGDRRA
>NZ_CP029197.1|WP_015034046.1|3117898_3118348_+|hypothetical-protein
MTGPEHYREAERLLGMAHHWTYGDGADPVVGAALAAEARGHATLALAAAQLTPAASSGAVTVFRVAYEHSPFPVGLYANAEAARAHCEDLVSDEHPADVALLFVWASVDEDEPESVCELTVRIGDEETPTGYTVTAVVAEASYDPEADA
>NZ_CP029197.1|WP_015034045.1|3117527_3117902_+|hypothetical-protein
MATDPTDFCPNEQCGGARDACGCPSDLTTQSLMVCLVCGGRWWRPYDSDSFRCPHPGCGQDMSLITIPAARRPERGEDGQPLDTDDGPDGDECHAEFIDGSWTYCGCPECDEREENDTEMELYG
>NZ_CP029197.1|WP_015034044.1|3117036_3117528_+|hypothetical-protein
MLTTDRVAEILAGQRSYRTVAQLDRDVRDLLAERAEILAQLTRGKDTAQGGESTPAPHRAEVRFTAYGLVPLIGPVVEDLEPDYYGHVYRQLGGWLPDTWSGEHLRGTEHMEFAHVPGLVMPTDINVQVSTRTSRDGSRYMAIQWRRERPSAVRRPAFPTVDA
>NZ_CP029197.1|WP_015034043.1|3116705_3116930_+|hypothetical-protein
MIHRTQLPPEASRLVRAADGSHWRTAGHTATGEQLYVLDGVDVDTCPMWVREREALLVELTGGPLAPVDEGAAA
>NZ_CP029197.1|WP_015034042.1|3116386_3116629_+|hypothetical-protein
MTFSRNYKVREAAELLGCAERYLTDNLARLPHQKIGVAVVFDDDDLTEIKEMHRRRPRAAAADKAPRSLAQIRPKGARAS
>NZ_CP029197.1|WP_015034041.1|3116171_3116390_+|helix-turn-helix-domain-containing-protein
MLSLKVDGRKVRRLREGRGKSVVAVAEAAGCSKWAIYNVERGRNQPSARLYAAIKKELKASDKDLSVEGSSR
>NZ_CP029197.1|WP_015034051.1|3121016_3121328_+|hypothetical-protein
MSTPHGSTPCPSCGQPIRWATTAAGRRQAVNALANSAGNLGAYTDGTGRLRVRVLTTERPTLEGAEWRAMPHAATCTRPAPRRTAQPRRRAGVRAARWQGWQR
>NZ_CP029197.1|WP_015034052.1|3121324_3121981_+|helix-turn-helix-transcriptional-regulator
MTAHDAGAVPAAVAAVIAAQILSRLGTRITPEEAGSLGRSAVDALRADGWVIRANVGRTLVQAAPGLWEHDLPILAGLARGRTGNEIAEATSTPAATVRQRIRRLRARTGASNSPELVAIAYRAGWLDSLPAEPRAPIHLPDLETRVLEHLAAGRTNPELALALGVSVPTAVNYVRRLCNALDAARPGEPDHSSRCRAVALGYQHGHLSRPARQPAAA
>NZ_CP029197.1|WP_167537156.1|3122011_3122266_+|WhiB-family-transcriptional-regulator
MPLSTPSAPAPGFHGLGLCAQTDPDTFFPERVNSATTRYAKEICLQCSFRGACLQWALNRGEEHGVWGGLDERERRNLRRARTA
>NZ_CP029197.1|WP_051025877.1|3122301_3123294_+|hypothetical-protein
MFPTLIHTPGLRRFTYDVDAERQAQIARFGEQRHPDGTGRPGYAEKANTAREACQMDAVIADGGPRWSLILLKAVHEALAESDPARLRAELVQVAAVCAAWASDMDQRSAGTSEAEAVAAASVKLREILAPGSAAEQQATAAYAAALDQGAAAHPSDVEATRAHIASLSEDLTEQEQRRLASVAAAIYEWNNPNRPWDAAHPHDRICYSGDAYAALTALRVPEPAGSYAIGFRLHPGRGAPLDGALLPSGRCLVVEDVEGGLITGAASVDDLVRGHPDARVEWPEQDTVTRVRAWCDDLDASVRLQHGAPQAEHPHAVALRAIIDPQESP
>NZ_CP029197.1|WP_015034055.1|3123290_3123983_+|hypothetical-protein
MSLCLICTHDAGPSRTACARCEHRLRGWLGEIPRQMVLLTASLELGSRPAQGYGGAGRAHSPLPVRGDVLNLLGPAAPGPVRDTAGDQSDQQPIHAVLHAWADQLAEDLGHMLPPINPSAPYAAYLARHLGHVVRSSWVALLHAELNDLVRRVRDITSTEPRRHTLDAPCPSCAAFTLGRVDWESYIDCESCGLLLTPDEYDDHRAAVMPPLARIGVLLAAHHHLTQEAS
>NZ_CP029197.1|WP_015034056.1|3123979_3124507_+|HTH-domain-containing-protein
MTTPTDAFTIAQRRAAVAELLRDNMSQRKIAERLGVTKDVVYRDIQALSRVTATPPNQDRRAPVAPDILTVALPAAASSPDPTTPSRDTATPAALHLAVPLDAALVADLATLTRNGTAPEDAIRRAVAQAAKGYRLAWGIGLYPRTTDPVVSRHQFVPYQPTEHETASPPDPPTR
>NZ_CP029197.1|WP_015034057.1|3124622_3124883_+|hypothetical-protein
MATLYTAAEAAAQATRWRRLLSAGAAEVTPAAVRQWARRGHLAPAGLDDRGHPVYAHVDVARAELATRSRALRLVGIPEAAPPSTR
>NZ_CP029197.1|WP_145953707.1|3124977_3125160_+|hypothetical-protein
MQYRSTGEVSYACACGYASGWVAADSIDSGTLRLQHPTGQPAPYRIVPGEVLASTPQERP
>NZ_CP029197.1|WP_015034059.1|3125156_3125363_+|hypothetical-protein
MNPPQARHYGAGLPRWVGAWFVMDSPGIYATTGARAPDGPLHVSLVVHVPRIRGALYGAWLLLTRRNV
>NZ_CP029197.1|WP_078508881.1|3125548_3125731_+|hypothetical-protein
MCKAAPATQADHWPLSKRELQARGLDEHDPRRGRGLCASCHSKETARHQPGGWNAGGPRY

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Crispr_ID: NZ_CP029197_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_13

3519274-3519381

Orphan

Consensus_repeat	Method
GGTGGTCGGCGGGGGTTCCTCGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_13

>merge|NZ_CP029197|13|3519274-3519381|CRISPRCasFinder
GGTGGTCGGCGGGGGTTCCTCGGTGGTCGGCGGCGGCGTCGTCGGCTCCGTGGTCGGCGGACTCGTCGGCGGTGTCGTGGGCTCGGTGGTCGGCGGGGGTTCCTCCGT

>NZ_CP029197|13|12|3519274-3519381|CRISPRCasFinder
GGTGGTCGGCGGGGGTTCCTCGGT	GGTCGGCGGCGGCGTCGTCGGCTCCGTGGTCGGCGGACTCGTCGGCGGTGTCGTGGGCTC
GGTGGTCGGCGGGGGTTCCTCCGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015034408.1\|3517356_3518289_-\|Ppx/GppA-family-phosphatase	unknown	unknown	gnl\|CDD\|223326
NZ_CP029197.1\|WP_086024692.1\|3509379_3510168_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP029197.1\|WP_030324225.1\|3523092_3524217_+\|DNA-integrity-scanning-protein-DisA	unknown	unknown	gnl\|CDD\|237395
NZ_CP029197.1\|WP_015034407.1\|3516314_3517151_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
NZ_CP029197.1\|WP_015034400.1\|3508645_3509383_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|366444
NZ_CP029197.1\|WP_015034411.1\|3521170_3522565_+\|DNA-repair-protein-RadA	unknown	unknown	gnl\|CDD\|236994
NZ_CP029197.1\|WP_015034417.1\|3527862_3528627_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034404.1\|3511420_3513649_+\|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl\|CDD\|270916
NZ_CP029197.1\|WP_015034420.1\|3530918_3532499_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP029197.1\|WP_015034406.1\|3515706_3516318_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380054
NZ_CP029197.1\|WP_015034419.1\|3529483_3530800_+\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_CP029197.1\|WP_015034418.1\|3528737_3529439_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP029197.1\|WP_015034403.1\|3510939_3511263_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|227324
NZ_CP029197.1\|WP_041662535.1\|3524304_3525147_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369035
NZ_CP029197.1\|WP_071891356.1\|3518330_3519158_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034405.1\|3513727_3515581_-\|dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|237104
NZ_CP029197.1\|WP_015034402.1\|3510376_3510904_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015034414.1\|3525375_3526047_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239489
NZ_CP029197.1\|WP_015034416.1\|3527302_3527875_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP029197.1\|WP_015034415.1\|3526080_3527016_+\|A/G-specific-adenine-glycosylase	unknown	unknown	gnl\|CDD\|224115

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015034408.1\|3517356_3518289_-\|Ppx/GppA-family-phosphatase	gnl\|CDD\|223326	COG0248, GppA, Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism].	7.48955e-80
NZ_CP029197.1\|WP_086024692.1\|3509379_3510168_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	3.10559e-79
NZ_CP029197.1\|WP_030324225.1\|3523092_3524217_+\|DNA-integrity-scanning-protein-DisA	gnl\|CDD\|237395	PRK13482, PRK13482, DNA integrity scanning protein DisA; Provisional.	0
NZ_CP029197.1\|WP_015034407.1\|3516314_3517151_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	2.04936e-27
NZ_CP029197.1\|WP_015034400.1\|3508645_3509383_-\|ABC-transporter-permease	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	1.0093e-25
NZ_CP029197.1\|WP_015034411.1\|3521170_3522565_+\|DNA-repair-protein-RadA	gnl\|CDD\|236994	PRK11823, PRK11823, DNA repair protein RadA; Provisional.	0
NZ_CP029197.1\|WP_015034420.1\|3530918_3532499_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.40846e-69
NZ_CP029197.1\|WP_015034406.1\|3515706_3516318_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380054	pfam17920, TetR_C_16, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins found in Actinobacteria. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.	2.45539e-33
NZ_CP029197.1\|WP_015034419.1\|3529483_3530800_+\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	9.59268e-32
NZ_CP029197.1\|WP_015034418.1\|3528737_3529439_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.94815e-82
NZ_CP029197.1\|WP_015034403.1\|3510939_3511263_-\|SH3-domain-containing-protein	gnl\|CDD\|227324	COG4991, COG4991, Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown].	4.82088e-11
NZ_CP029197.1\|WP_041662535.1\|3524304_3525147_-\|hypothetical-protein	gnl\|CDD\|369035	pfam06682, SARAF, SOCE-associated regulatory factor of calcium homoeostasis. SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.	0.00710092
NZ_CP029197.1\|WP_015034404.1\|3511420_3513649_+\|PQQ-binding-like-beta-propeller-repeat-protein	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.24971e-83
NZ_CP029197.1\|WP_015034405.1\|3513727_3515581_-\|dihydroxy-acid-dehydratase	gnl\|CDD\|237104	PRK12448, PRK12448, dihydroxy-acid dehydratase; Provisional.	0
NZ_CP029197.1\|WP_015034414.1\|3525375_3526047_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239489	cd03395, PAP2_like_4, PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.48776e-17
NZ_CP029197.1\|WP_015034416.1\|3527302_3527875_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	3.32574e-56
NZ_CP029197.1\|WP_015034415.1\|3526080_3527016_+\|A/G-specific-adenine-glycosylase	gnl\|CDD\|224115	COG1194, MutY, A/G-specific DNA glycosylase [DNA replication, recombination, and repair].	1.08586e-82

>NZ_CP029197.1|WP_071891356.1|3518330_3519158_+|hypothetical-protein
MPKTKKAKPGKDGPVKSAKKRGKNVEPDEKGLDFARAWVEFPDPADEEQVFRCDLTWLTSRWTCIFGSGCQGIQAGRADDGCCTLGAHFSDEDDEKRVASHVARLTPELWQFHDVGTASGWTQTDEDGDRQTRRWEGSCIFQNRPGFAGGAGCSLHILALREGKEPLETKPDVCWQLPVRRTYDWIERPDDTKVLQVSIGEYDRRGWGPGGHDLHWWCTSATSAHGAGEPVYVTYRPELTEMMGKEAYEVLAGLCAARLASQLPLVAPHPADPKG
>NZ_CP029197.1|WP_015034408.1|3517356_3518289_-|Ppx/GppA-family-phosphatase
MRLGVLDVGSNTAHFLVVDAHPGARPLPAHSHKAELRLAELLDERGAIAPHGVERLIATVRDALLAAEDKGCEEVLPFATSAVREASNADAVLARVKDETGVDLQVLTGEEEARLTFLAARRWFGWSAGKLLLLDIGGGSLEVAYGIDEDPDTAVSLPLGAGRLTAGWLPGDPADSADVKALRRHVRAQIARTVGEFSRSGRPDHVVATSKTFKQLARIAGAPGSGEGLYVQRILTRRALEEWVPRLAGMTVPERAALPGVSEGRAGQLLAGAMVAEGAMDLLGVEELEICPWALREGVILRRLDHLPTK
>NZ_CP029197.1|WP_015034407.1|3516314_3517151_-|sugar-phosphate-isomerase/epimerase
MAEPVVRIPDAKVALSTASVYPESTATAFEIAARLGYDGVEVMVWTDPVSQDIEALRRLSDYHQVPILAVHAPCLLITQRVWSTDPWVKLQRAQAAAERLGASTVVVHPPFRWQRQYAKDFVTGIWRMADETDVRFAVENMYPWRYKDREMLAYAPEWDVTKDDYRHFTVDLSHTATARTDALAMIDRMGDRLGHVHLADGKGSAKDEHLVPGRGTQPCAELLERLARTGFDGHVVIEVNTRRAMSAAEREADLAEALAFTRLHLASAAGRPSRVPRP
>NZ_CP029197.1|WP_015034406.1|3515706_3516318_-|TetR/AcrR-family-transcriptional-regulator
MTGPAPRRRGRPSRTEEETGPGARERILEAARAQFAERGYDKTSVRGIGKAAGVDPALVHHYFGTKDEVFAAAIEVSFEPAAVVPAIVGGPRDSIGERLARFFIGVWENPASRAPLLAIVRSALTHEAAAKVLRTFVLRRLLERIAAELDVPDPKFRAELAASHMIGIAILRYVIQVEPMASADPERIVEMVAPTLQRYLTEA
>NZ_CP029197.1|WP_015034405.1|3513727_3515581_-|dihydroxy-acid-dehydratase
MPELRSRTVTHGRNMAGARALMRASGVPGADIGRKPIIAVANSFTEFVPGHTHLQPVGRIVSEAITAAGAIPREFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVEAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMESGRATLVDGTVRTLDLVDAISDAVNPNISDEDIARIEENACPTCGSCSGMFTANSMNCLTEAIGLSLPGNGSLLATHTARKGLYEAAARTVVDITRRYYDEDDDSVLPRSIATRAAFENAMALDIAMGGSTNTILHLLAAAQEAELDYGLSDMDEVSRRVPCLAKVAPNVAKDRTYYMEDVHRAGGIPAILGELYRAGLLNEDVHAVHSRSIKEWLGTWDVRGGSPSEESVELWHAAPGCVRSATAFSQSERWAALDVDAAGGCIRDAAHAYSKDGGLAVLRGNLAVDGCVVKTAGVDESIWTFEGPAVVCESQDEAVEKILNKQITDGDVVVIRYEGPRGGPGMQEMLYPTSFLKGRGLGKTCALVTDGRFSGGTSGLSIGHASPEAASGGTIALVEDGDRIRIDIPSRSIELLVDEATLAARREALGGVYQPKNRQRKVSAALRAYAAMATSADKGAVRDVTKLG
>NZ_CP029197.1|WP_015034404.1|3511420_3513649_+|PQQ-binding-like-beta-propeller-repeat-protein
MPPLRGTGADREAEGPEYAGDYRLQACLGAGGMGVVHLAASASGLRLAVKVVHARYAEDPEFRARFRQEVAAARRVSGAFTAPVVDADPDAVRPWMATLYVPGPTLADQVKRNGPLAPAELRRLTAGLAEALRDIHRAGVVHRDLKPSNVLLTDTGPKVIDFGISRPVDSDLHTETGKLIGSPPFMAPEQFQRPREVGPAADVFALGSVLVHAATGHGPFDSDSPYIVAYQVVHDEPDLTGVPAELAPLVARCLAKDPAERPSPAQIMAALLPPSYAAEAFIPAQRRRPSLPDGEDGAYGETGSRGGRGEPGPSPAWDADTPVRATAPVPPRRARPLRGGRLRPRLTIAVAAAVALAGAGIYAAMSPPARGGTEPPARPGEVATAFAGWETTLQKHGPTAAPACAHGEGALYCAARGVGLARLDPVTGKVLWSLDAPVKAESPLAPFVLTGGARGTGGLVGAAAPTGPLRAYTAERGAPAWSTSSKLPESFRPAGSAVVLTDGQGGVRAVDGQSGKELWRHGLSGFDVPRPGPYDSVSGLLAVSETSADGTHTRVGEFRARTGEVVRQRNLRGALEPLGRTSDGALVLGSLYQASLYDALVLLDPAGGSVRRLPLPHRIDVRGVAVHGSVAHVLDADGHLTAFDTAAPKGRVLWELETGAGNVSTPVVGPGDRLYFSVQDGRLLAVDTVRGALVGQTRPRLLNGRLDYAPLVPPPLVAGDRVFGTAPDGSVFAVDARDPASW
>NZ_CP029197.1|WP_015034403.1|3510939_3511263_-|SH3-domain-containing-protein
MSTDENTTTATATTAGETVAAMASTATRYAVAPGYRVNVRSGPSTQYPVVRSLPLGATVAISCQKYGEWITGPYGTTKIWDNIAPGEYVSDAYVRTGSDGLVAPRCA
>NZ_CP029197.1|WP_015034402.1|3510376_3510904_-|hypothetical-protein
MSDEEQTPSPTGGPTGGTPAGPQPEEVRFFGTTWVDHSGNYTLRRVGLAAGSLAAAVAACFVLRFAYEGLQIAAVGGIVNMLVVIMFAVCSAIAFRKTWEGYLRRPADPAREESLRSLKMIGFIGALLAYCARCFVEAPGEKLRRAEYETARAQFEKRRGARTGNPAARKKPKRK
>NZ_CP029197.1|WP_086024692.1|3509379_3510168_-|ABC-transporter-ATP-binding-protein
MTARDLTVVRGDRTVLHGLDFTVTAGRITGLLGPSGCGKSTLMRAIVGTQAKVDGTLHVLGRPAGDPTLRSRIGYVTQAPSVYDDLTVRQNLDYFAAVLLPGRAHREERRTAVDRAIDDVDLASHADHLAGRLSGGQRSRVSLAVALLGTPELLVLDEPTVGLDPVLRRDLWNLFHQIAADRGTTLLVSSHVMDEAERCHRLLLMREGEILADDTPEALRRRNDTATVEEAFLHLVDAAAARTAQAAQATQAARAAHEEPRP
>NZ_CP029197.1|WP_015034400.1|3508645_3509383_-|ABC-transporter-permease
MSPARTLATAARVLRQLRHDPRSIALMLLVPCVMLFLLRYVFDGSPGTFDNIGASLLGIFPLITMFLVTSIATLRERTSGTLERLLAMPLGKSDLIAGYALAFGLLAVVQSTLATGLAVWFLGLDVIGSPWLLLLVALLDALLGTALGLFVSAFAASEFQAVQFMPAVIFPQLLLCGLFTPRDHMAPALEAISDVLPMSYAVDGMNQVLRHPDIPGDFVRDALVVAGCALLVLGLGAATLRRRTA
>NZ_CP029197.1|WP_015034411.1|3521170_3522565_+|DNA-repair-protein-RadA
MAARTKSTKDRPSYRCTECGWQTAKWLGRCPECQAWGTVEEYGAPAVRTTAAGRVSTAALPIGQVDGRQATARSTGVDELDRVLGGGLVPGAVVLLAGEPGVGKSTLLLDVAAKAASDEHRTLYVTGEESASQVRLRADRINALSDHLYLAAETDLSAVLGHLDAVKPSLLIMDSVQTVASPEIDGAPGGMAQVREVAGALIRASKERGMSTLLVGHVTKDGAIAGPRLLEHLVDVVLSFEGDRHARLRLVRGVKNRYGATDEVGCFELHDEGITGLADPSGLFLTRRDVAVPGTCLTVTLEGRRPLVAEVQSLTVDSQIPSPRRTVSGLETSRVSMMLAVLEQRGRISALGKRDIYSATVGGVKLTEPAADLAIALALASAASDTPLPKNLVAIGEVGLAGEVRRVTGVQRRLAEAHRLGFTHALVPSDPGKVPAGMKVTEVADMGDALRVLPRGRRAKTAEA
>NZ_CP029197.1|WP_030324225.1|3523092_3524217_+|DNA-integrity-scanning-protein-DisA
MAAKDGAAAPGKSGAGSGNEALMRAALSAVAPGTALRDGLERILRGNTGGLIVLGLDKTVDSMCTGGFVLDVEFAATRLRELCKLDGALVLDKDITKIHRAGVQLVPDASIPTEETGTRHRTADRVSKQCNFPVVSVSQSMRLIALYVDGERRVLEESAAILSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVAQRLEMVRRIATEIAEYVVELGTDGRLLSLQLDELIAGVEPERELVIRDYVPEPTAKRSRTVAEALTELDALTHTELLELPVVARALGYSGSPETLDSAVSPRGYRLLAKVPRLPGAIIERLVEHFGGLQKLLAASVDDLQTVDGVGEARARSVREGLSRLAESSILERYV
>NZ_CP029197.1|WP_041662535.1|3524304_3525147_-|hypothetical-protein
MGSLRNPVGPLPSTIYWRRRAVAACLVALLALLTVWAVTSGGGGGKKTNDGANGSSPTPPSITPGPSGTGPAISQQPGGRDESDDSGDTTGGDAGSGGPGTDPGTGTGTDAGTAAGTDGGKNGDTDGAGGDGGAGTGAGQRVPANSPLPNCPAGSLQLTLRSAKVSYEPGEKPRFHLVAKNPSTTDCKADFGPRTAILTISDGKNGEFWSSADCPRPGDPILLKVPAGATVTHTVEWDRGRSAPQCATTPAGQAGPGTYLVEAKVPGAKVLPASFTLAKD
>NZ_CP029197.1|WP_015034414.1|3525375_3526047_+|phosphatase-PAP2-family-protein
MNTLLDLSDRLYLDVADFAHSTPHWFQWLAEVWTEAGLLLFGVLFLAGWWRAREGASRMMALALLAPLATAFGYVVSESLKSLVDEERPCRAVIGAPASLVACPPHGDWSFPSNHSAIAGAAAIALALSWRGIGRLTVPMAILMAFSRVFVGVHYPHDVTVGLLLGGLVAFLVMKAAVRPVGALVETARSSRSAAVVWCAGRGPRAHAPAYAQEPQRARHGAY
>NZ_CP029197.1|WP_015034415.1|3526080_3527016_+|A/G-specific-adenine-glycosylase
MTSIDASPMPEAPSAPALPTPPAELHGPVLAWFDRHARDLPWRRPEAGAWGVMVSEFMLQQTPVVRVLPVYEQWLARWPRPADLAAEASGEAVRAWGRLGYPRRALRLHAAAVAITERHGGDVPSDHGQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARAATGVQYPPNATTAAERRLARALLPQDESTASRWAAASMELGALVCTAKNEDCSRCPIAGHCAWRLAGKPAHDGPPRRGQTYAGTDRQVRGRLLAVLRESTDPVAQAVLDTVWDEPVQRARALDGLVADGLVEPLDGGYFRLPMA
>NZ_CP029197.1|WP_015034416.1|3527302_3527875_+|SigE-family-RNA-polymerase-sigma-factor
MRHGEVLDFEEYVRTRQEALLRSARRLVADPVDAQDLLQTALARTFGRWDGIADKSLADAYLRRVMINTRTEWWRSRKLDEVPTEQLPDASVDDPTEQHADRALLMDVLKVLAPKQRSVVVLRHWEQMSTEETAAALGMSTGTVKSTLHRALARLRQELESRDLDARALGRTGERTTVRGDERGRERCAA
>NZ_CP029197.1|WP_015034417.1|3527862_3528627_+|hypothetical-protein
MRGLDGEADGSRHDRDSGIDSGDGAGGGDRYGTGRRRRRGTAKAASITAAAGLVAVGLSMAACSTGGTGSRDEGAAATKEVAAAAPTPSASPGGGQRSAERVDPIALLKGDPKIGERLKTDLKPCVADAYPVDTSYGNLTNAAAPDVVVNVMTCGDAVGIGTYVYRKQSDRYENVFMAEDAAVYGTIDRGELVVTKQVYAKGDPVAYPSGEDVITYRWSGNGFTQHDWVHNDYSRAVDGGSAVTEPAPSEPPVR
>NZ_CP029197.1|WP_015034418.1|3528737_3529439_+|response-regulator-transcription-factor
MAETHVLFVEDDDVIREATQLALERDGFRVTAMPDGLSGLDAFRAQRPDIALLDVMLPGMDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGSVLMARIRAVLRRFGHAGGPGAGEHGEETPDGGLLAFGDLEVDTEGMEVRKAGAPVALTPTEMRLLLEFSSAPGTVLSRDKLLERVWDYGWGGDTRVVDVHVQRLRAKIGQDRIETVRGFGYKLKS
>NZ_CP029197.1|WP_015034419.1|3529483_3530800_+|HAMP-domain-containing-histidine-kinase
MKLLPLRTGVRWKIAVAIAAVGALIAVTLSVVVHNAARISMLDNAREVQMERLLFAQRMYETSKPKEPRFGTKINDPSLPPQLDQLMRDKRRGTYVQEHRHGGPPDVWAAVPLANGDVLSLHIPFADRSATIMNDLDRALVIGSVSVVFGGCALGVLIGGQLSRRLRKAAVAAGRVAQGNTDVRVREAVGGVVRDETDDLAWAVDALTDALNERIEAERRVTADIAHELRTPVTGLLTAAELLPPGRPTELVRDRAQAMRTLVEDVLEVARLDSASERAELQEIALGEFVERRVRALDPEVVVRVVHDSWVNTDPRRLERVLGNLLANAAKHGRPPVEVTVEGRVVRVRDHGPGFPEALLKEGPSRFRTGTSDRAGQGHGLGLTIAAGQARVLGARLTFRNVASEAAPNGVGGAIAVLWLPDHAPTNTGSFPILRPAD
>NZ_CP029197.1|WP_015034420.1|3530918_3532499_-|MFS-transporter
MTTQATANPVQGETEPQPRSVRVVLLALMIAMLLAMLDNMIIGTAMPTIVGELGGLEHLSWVVTAYTLATAASTPLWGKVGDMFGRKGVFLTSIVIFLIGSALSGMAQDMGQLIGFRTIQGLGAGGLMVGVMAIIGDLIPPRERGKYQGMMAGVMALAMIGGPLVGGTITDHWGWRWSFYINLPLGAVALAMITTVLHLPKKQRDKGTRIDFLGAALLTVGITAIVLVTTWGGTEYAWGSATIVGLAVGGALALAAFLWAETRAADPIMPLHIFRSRNFTLMSLIGFITGFVMFGAVLYLPIFQQSVQGASATNSGLLLLPMLLAMMVVSLVVGRFTTSTGKYKIFPIIGGALMMTGLFLLSTMDTGTSRLVSGIWMAVLGAGMGFLMQITMLVAQNSVEMKDMGVASSSTTLFRTLGSSFGVAIMGALFTSRVQDEMASRGGGGLTERTAQLDAASLAKLPEALREAYQHAVATGTHGAFLVASAVSVLGLVLAFFVKEVALRGAGPAPAPTTESGESAKVAETV

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Crispr_ID: NZ_CP029197_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_14

3593915-3594112

Orphan

Consensus_repeat	Method
GTGCCGGCCTCCCCGCCG	CRT

4 spacers

The CRISPR arrays of NZ_CP029197_14

>merge|NZ_CP029197|14|3593915-3594112|CRT
GTGCCGGCCTCCCCGCCGGCATCCGCGCCGGCCTTCCTACCGGCCACCGTGCCGGCCTCCGCGTCCGCCTGCCTGCGGGCGCCCGTGCCGGCCTCCCCGCCGGCTACTGCGCCGGTCTCCGCGTTGGCCTCCCCGTCGGCCACCGTGCCGGCCTCGCCGCCGACCTCCCCGCCAGCCACCGTGCCGGCCTCCCCGCCG

>NZ_CP029197|14|2|3593915-3594112|CRT
GTGCCGGCCTCCCCGCCG	GCATCCGCGCCGGCCTTCCTACCGGCCACC
GTGCCGGCCTCCGCGTCC	GCCTGCCTGCGGGCGCCC
GTGCCGGCCTCCCCGCCG	GCTACTGCGCCGGTCTCCGCGTTGGCCTCCCCGTCGGCCACC
GTGCCGGCCTCGCCGCCG	ACCTCCCCGCCAGCCACC
GTGCCGGCCTCCCCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_051025889.1\|3592048_3592696_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP029197.1\|WP_015034479.1\|3591362_3591935_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP029197.1\|WP_015034487.1\|3599585_3601766_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
NZ_CP029197.1\|WP_015034471.1\|3585324_3585939_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
NZ_CP029197.1\|WP_015034484.1\|3597323_3597713_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP029197.1\|WP_015034476.1\|3589373_3589871_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP029197.1\|WP_015034493.1\|3607341_3608649_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_078508671.1\|3596034_3597345_-\|DUF2786-domain-containing-protein	unknown	unknown	gnl\|CDD\|378525
NZ_CP029197.1\|WP_015034482.1\|3595228_3595897_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NZ_CP029197.1\|WP_015034470.1\|3584114_3585176_-\|daunorubicin/doxorubicin-resistance-ABC-transporter-ATP-binding-protein-DrrA	unknown	unknown	gnl\|CDD\|130256
NZ_CP029197.1\|WP_015034490.1\|3603027_3603954_-\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176191
NZ_CP029197.1\|WP_015034478.1\|3590424_3591366_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029197.1\|WP_015034489.1\|3602393_3602951_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP029197.1\|WP_015034474.1\|3588195_3589068_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP029197.1\|WP_015034473.1\|3586652_3588110_-\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143469
NZ_CP029197.1\|WP_015034485.1\|3597819_3598638_+\|NAD(P)H-binding-protein	unknown	unknown	gnl\|CDD\|187578
NZ_CP029197.1\|WP_015034491.1\|3604098_3605343_+\|response-regulator-transcription-factor-family-protein	unknown	unknown	gnl\|CDD\|225107
NZ_CP029197.1\|WP_041662542.1\|3585998_3586541_-\|DinB-family-protein	unknown	unknown	gnl\|CDD\|368218
NZ_CP029197.1\|WP_041662544.1\|3605538_3607230_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	unknown	unknown	gnl\|CDD\|237876
NZ_CP029197.1\|WP_015034477.1\|3590021_3590264_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_051025889.1\|3592048_3592696_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	3.76182e-08
NZ_CP029197.1\|WP_015034479.1\|3591362_3591935_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	3.66964e-44
NZ_CP029197.1\|WP_015034487.1\|3599585_3601766_+\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	3.78295e-10
NZ_CP029197.1\|WP_015034471.1\|3585324_3585939_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.08049e-11
NZ_CP029197.1\|WP_015034484.1\|3597323_3597713_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	3.3349e-38
NZ_CP029197.1\|WP_015034476.1\|3589373_3589871_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	6.6297e-22
NZ_CP029197.1\|WP_078508671.1\|3596034_3597345_-\|DUF2786-domain-containing-protein	gnl\|CDD\|378525	pfam10979, DUF2786, Protein of unknown function (DUF2786). This family of proteins has no known function.	2.38139e-13
NZ_CP029197.1\|WP_015034482.1\|3595228_3595897_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.26823e-25
NZ_CP029197.1\|WP_015034470.1\|3584114_3585176_-\|daunorubicin/doxorubicin-resistance-ABC-transporter-ATP-binding-protein-DrrA	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	5.55664e-116
NZ_CP029197.1\|WP_015034490.1\|3603027_3603954_-\|NADP-dependent-oxidoreductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.77391e-89
NZ_CP029197.1\|WP_015034478.1\|3590424_3591366_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.99358e-05
NZ_CP029197.1\|WP_015034489.1\|3602393_3602951_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	2.42533e-24
NZ_CP029197.1\|WP_015034474.1\|3588195_3589068_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.77455e-08
NZ_CP029197.1\|WP_015034473.1\|3586652_3588110_-\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143469	cd07151, ALDH_HBenzADH, NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like. NADP+-dependent, p-hydroxybenzaldehyde dehydrogenase (PchA, HBenzADH) which catalyzes oxidation of p-hydroxybenzaldehyde to p-hydroxybenzoic acid and other related sequences are included in this CD.	0
NZ_CP029197.1\|WP_015034485.1\|3597819_3598638_+\|NAD(P)H-binding-protein	gnl\|CDD\|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.76834e-57
NZ_CP029197.1\|WP_015034491.1\|3604098_3605343_+\|response-regulator-transcription-factor-family-protein	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.23313e-16
NZ_CP029197.1\|WP_041662542.1\|3585998_3586541_-\|DinB-family-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	4.76855e-46
NZ_CP029197.1\|WP_041662544.1\|3605538_3607230_+\|bifunctional-3'-5'-exonuclease/DNA-polymerase	gnl\|CDD\|237876	PRK14975, PRK14975, bifunctional 3'-5' exonuclease/DNA polymerase; Provisional.	0
NZ_CP029197.1\|WP_015034477.1\|3590021_3590264_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	3.30611e-19

>NZ_CP029197.1|WP_051025889.1|3592048_3592696_-|hypothetical-protein
MKKYWLAAAGVVAAVAIAAPSAVGASAQTPTATRPAAPAKPAAQAKPATPAKPAAPAPVVAPAKAAVPAPNPVRTVRAGQRVDAGQGYTVWLTRDGKHWSGPDGYENFRSVVDGNIDRSQPGVSHQSEGDATGVFHSGLFYGTRNVGRVELTDSAGRKTVATLLALPGRPDWGVWYASTGPVDGNGGGSHGVSLYDRGGKLLAELPRFDFPAGRG
>NZ_CP029197.1|WP_015034479.1|3591362_3591935_-|SigE-family-RNA-polymerase-sigma-factor
MTYESAADDDGFAEYAVAAWPRLVRTAQLLTGDFHEAEDLVQTTLAKVYGRWRRVPRGEIDLYVRRSLINNNLSRIRRKRVVHLLTPVLPESLRHTSAGHAEAVEQRTSILEALADLTARQRAVMVLRYWEDLTELEIASVLNCSIGTVKTHARRGLAALRAHPRLATTAANAAAPVFPPPLPAPSGARR
>NZ_CP029197.1|WP_015034478.1|3590424_3591366_-|hypothetical-protein
MTPASPATPPDRAPDSGSGDEGSDATGPTSDDGSDAADPTGDDGSYATGPTGDDGSDAADLATAADLRAAFARAAFDVTPGPVPLAAVRRAGRARRRRRTTAFSALSVLGVATAVAAVVVLTPVRPAPLSSGPEPVAVPPTGVPSAAAASSAPAVRTSQQPPPPPAPTPIKVVASGERVAAGKGWKVWLTKEGKHWTGPDGYENSRSVTDGNIDLGSPGVSHQSEGDAKGVFHSGVYYGTRTAGRVELRNAAGRTIVATLLELPGKPGWGVWYAHGGAKDGEMSPVLYDRSGVRLAELPLMPAGDPGSGDQNP
>NZ_CP029197.1|WP_015034477.1|3590021_3590264_-|DUF397-domain-containing-protein
MHHAHRAYNGMAATELRGVVWQKSRHSNSQGSCVEFAKLPGGNVAVRNSRHPDGPALVYTPAEIEALLLGVKDGEFDHLV
>NZ_CP029197.1|WP_015034476.1|3589373_3589871_+|ATP-binding-protein
MGTNGSTVLEPLRQGLPPIDPGAVSTSASCALPARYEAVRGARKFTSATLDRWELTERFDDVALVVSELVTNALRHAVPADAPQEEGQNPPVRLHLMRWSSRLVCAVRDPSRQSPEARGGEEDFAAESGRGLFLVDSFSDSWGWHPLAGTLRGKVVWALFRIGPE
>NZ_CP029197.1|WP_015034474.1|3588195_3589068_-|helix-turn-helix-domain-containing-protein
MTAGESGGASGSVVRRILLGSQLRRLRESRGITREAAGYSIRASESKISRMELGRVSFKARDVEDLLTLYGVGDEAERGSLLGLAREANVAGWWHSFGDVLPGWFQTYIGLEGAASLIRVYEVQFVHGLLQTEAYAQAVVTRGMPDAPAAEIDRRVALRLERQKVLVSERAPQFHAVLDEAALRRPYGDRSVMRGQLRHLIEVSEHPGVTLQIMPFSFGGHAGESGAFTMLSFPESDLSDIVYLEQLTSALYLDKREEVAQYQRVMERLQKEGPDPAESRDLLRGLLQLI
>NZ_CP029197.1|WP_015034473.1|3586652_3588110_-|aldehyde-dehydrogenase-family-protein
MSHFTDLAHQYIDGEWKPGSGSWDIIDFNPYTGEKLASITVATAGEVDRAYRAAERAQAEWAETNPYTRRLVFERALRIVEDREDEISETIVAELGGTRLKAAFELHLAKEFLREAVQLALRPEGRILPSPVDGKENRVYRVPVGVVGVISPFNFPFLLSIKSVAPALALGNAVVLKPHQNTPICGGTLVAKVLEEAGLPAGLLNVVVTDIAEIGDALLTHPIPKVISFTGSDKVGRHVATVCAQNFKHAVLELGGNSALIVLDDADVDYAVDAAVFSRFVHQGQVCMAANRILVDRTVEEEFTEKFVAKVKTLRVGDPADPATHIGPLINSQQAEAVSTLVDQTVAAGATALLHGTVEGNLVSPSVLTGFAPDAPVLGQEIFGPVALIVPFDGEEEAVRIANDTPYGLSGAVHTGDVERGVRIAKRIHTGMIHINDGTVHDEPIVPFGGEKHSGIGRLNGEAMVESFTTQKWISIQHGRSRFPF
>NZ_CP029197.1|WP_041662542.1|3585998_3586541_-|DinB-family-protein
MVALVPTETYGDERGALLNFIEAQRAAIRRSLLGLTEEQAASRPSASELSLSGLLKHVAEVELNWLRLAQQRPNERQRTQDTWDEAFRLMDGETIPEIVEFWAGVAKETEEYVRSVPNLDDTFPLPPAPWFPAGGRVSIRWMLLHLVQEAGRHAGHADIIRESLDGKGSFELIAAEQGQG
>NZ_CP029197.1|WP_015034471.1|3585324_3585939_-|PadR-family-transcriptional-regulator
MSAIRLLVLGAVKQHGRAHGYQVRNDLEYWGAHEWSHAKPGSIYHALKQMAKQGLLHAHEVAPSAVGGPPRVEYELTERGLEEYFALLREALTTYDQRVDVLSAGIGFIVDLPRAEAAELLRQRVRALEEWRTAVTEYYTPEGGPGQLGHIGEIMHMWVHSADAGKEWTLGLIERIEGGAYVFAGEGDPFVGVLAEGEENPFAT
>NZ_CP029197.1|WP_015034470.1|3584114_3585176_-|daunorubicin/doxorubicin-resistance-ABC-transporter-ATP-binding-protein-DrrA
MAATQDAILVEGARKRYGEKEALAGLDLTVRRGTVHGLLGPNGAGKTTTVRILATLLRHDEGLVRVAGHDVRTGAREVRRRIGLLGQHAALDEELGGRQNLEMFGRLHHLGARRAGTRAEELLERFGLTDTGHKPVKQFSGGMRRRLDLAASLITEPEVLFLDEPTTGLDPRGRGEVWESVRSLVGGGTTVLLTTQYLEEADQLADRISVVDRGRVVADGTPDELKALVGVDRIDVVVRDGARLDEAAALLPFARAEVTVDGDRRRLSAPVADRMASLTETVRVLGEAGIEAEDIALRRPTLDEVFLRLTGGGDTPDGQDATGGPDGTGEPGTKGAPGGTEAPGGRQGREVTA
>NZ_CP029197.1|WP_015034482.1|3595228_3595897_-|class-I-SAM-dependent-methyltransferase
MRAHHIDRPSDLDVVRESYDRVADNYADMVVTTGIGDIRRHPWHKASIDAFADAVGGLGPVLDVGCGPGTVTAYLAERGLDVSGVDLSPRMIENARRLHPQCRFDVASATDLDLAEASLGGVLGWWSLFNLPRDVLPQVLARFARALKPGGHFITATHVGDEDVRRTEAYGGVPVRWTTHKWRPERFVDLIERAGLRTVAELRLPPEEYSGPGLVVMAQRPA
>NZ_CP029197.1|WP_078508671.1|3596034_3597345_-|DUF2786-domain-containing-protein
MGREDGVSTSNSSGTGGAGRAGGAGRTGGAGRAGGAGSTGGAGRAGGAGGTGGAGRARGTGGTLDRAFEALYATDDGSLDTAASLLAADRGADAELTRRGEEFVRTLWARGWQPADVVRIARRDLSEDHLRVLTGLIRTETARYERLPHRWQGQLDALDEQSGRRPSDRFSYATTVLELYRLLVRLPRLDAVGPVPGEALPPPTAGEPRMLGRIRALLAKAEATGYPEEAEALTAKAQELMARHSLDEATLAAGTPSPETPGAIRIGVEPPYEQAKAILLDAVATANHCRAVWNEAYGFSTVVGFEADLDPVELLYTSLLVQGTAAMTRAEAEQRAGGRKRTKSFRQSFLLAYANRLGARLAATSRRVEAEAPTLLPALASRDLAVTNRTDELFPETRTTRVRAAWDEEGWTHGASAADRAGLGPHRKGIDERGAR
>NZ_CP029197.1|WP_015034484.1|3597323_3597713_-|helix-turn-helix-transcriptional-regulator
MSEGHTEVTTEPLVSCAEECGVRDVQDRLGDKWTVHVVVELAPGPKRFRELQRLVTGISQRMLTLTLRRLERDGLVSRTVYPTTPPQVEYALTETGHSMTHLIKQLVDWSLDHRAVIARSREAWDARTA
>NZ_CP029197.1|WP_015034485.1|3597819_3598638_+|NAD(P)H-binding-protein
MLLVTGVSGALGALVAERLAGREDVVLGTRAGLPGTRRLDFDAPETLPEALTEVETLLLISAGYGEDDTVVARHEAAISAAEAAGVSHVVYTSLSGDGDHLTYALAHRWTERRLRNSPTLDWTILRNGLYAEFLTWIAAPDAENRITGPLGEGRLAAVARADLADVAVAVATDPGAHRNRVYELVGERALGGAELAEALGATYAPGTLAEARAAIAASGAVPFQVPMLASTYSAIAHGFMDGTGIASDLRTLLGGREPLDALDVFVKTVREG
>NZ_CP029197.1|WP_015034487.1|3599585_3601766_+|ABC-transporter-permease
MLIVALSSLRARWASFLGGFVALALGVGLLATMGLGLSATFHAPERSPQRFASSPVVVQGQDRLTLDVRRGPETVSVERRLDRPQPVDSRLLRELRARWTVTTSEEPADRRGPHRPGHPDHPDAVGVDAPAADVRALVGARAQVLTGDERRRADHDADRDADALVGLNALLGTSGGVTAFVSVFVVASTFAFAVALRRREFGLLRTAGATPGQIRRLLLAEAAALGVVASAAGCALGALGAPLLARTLVDGGLAPEWFTVGGPVWPFHTAFWTGVTVALAGAIAASRRAGKVGPTAALREADVDADALPLGRAVLGTGLLLAGVGLLVWTCVTDPSALLKRKTYTTLPMLLITGVALLSPLLVRPAARLLRLRGAVGTLVRENSAASVRRTAAVAAPVLVTVALAGTLFGSATSVTRAKGTEAREQTAAQYVVTGVDEPDRTGGPRPVAVPPGAVVSPTGPTSLFVRDGDAAVVKYGARAVTDPAAFAELARLPVVAGDLRDLDDRSIVVNEEFERRRVGETVEVWRADGTGPVRLRIAAVLALGTGDNGPYVTRANAPGSAPDRIDASGGGTATVQALEASGGTVRTAAAWAEAERPASGSPQARLGMVLVLGVALVYTVIGLANTLLMATSVRRGELASLRLAGATRAQILRVVTGEATLAVAIGTLLGLAVTALVLGTLGAGLAALSAPVALALPWTTVGASAGVCATVAIAASALPAWRLTR
>NZ_CP029197.1|WP_015034489.1|3602393_3602951_-|GNAT-family-N-acetyltransferase
MYAIPLGDEGGELRPLEPWQAEEFLAHMDRGREFIGARNGLPDVVTDLESSRAFLRLYAEKAAADTGRIHGIWFDGTLVGAVILRKLDAEDGTAEAGCWLEPAGAGKGLVTRAARLLIDWAIEVRGVHRVEWVVSSDNEPSIAVARRLGMSKDGVLRASYPYRGRRHDEEVWSVLAPEWRAAKSA
>NZ_CP029197.1|WP_015034490.1|3603027_3603954_-|NADP-dependent-oxidoreductase
MEATVYEEFGGPEVLRHTSGLAVPQPGPGEVRVKVAAVGVNPVDWKRRYGWVEEFYPTTFPAVPGLEFAGTVDQLGEGVTGLAVGDEVLGWTKTGAYAEYAIADIVVPKPAGLPWGIAASLPVAGETAQRVLDLLGVRAGETLFLHGAAGVVGSVGVQLAVAAGVTVIGSASESNHAYLRELGAIPVAYGEGLADRVRAAAPDGVHAVFDAAGHGVLPVAIELLGGGDAAKKRIVTIADVDAEKYGITFSGVIGEADAVRAGLTEHARGAAAGTLKVRLAETLPLKEAARAQELSESGHARGKLILIP
>NZ_CP029197.1|WP_015034491.1|3604098_3605343_+|response-regulator-transcription-factor-family-protein
MDAPTLTTAYEIIRQPLGEILPRVSAALAPLVPHVDAAELSTHCAHSPFKALGGTELLTASELVPLLAAGVPGSPWQGVATIGGREREIVAVTSDATRRGAVLVLVREDGADPVGEAELGVAQALWDLVAAHFDRFATEALPGALARSRAAADTRARVISELTATHAAALSGVLGVLRSRALDDTTARATATDLAAAALIEMRAAQRRDRALAEEPVQDAFERLAGELRPMLRHSQIRLDLGAPDSDRSLAADVAHSARAIVRALLLIVLEQKSVSRIHVGWQLTEHELRATVRDDGAGALAPCDLGAGTIKDRLDVLGGRLDMDAVPSWGTTITAVIPLATPDAPAEAAHPLADLGEREVEVLRHLALGHRNRRIAETLHISESTVKFHVANILNKLGVGSRGEAAALFHAAA
>NZ_CP029197.1|WP_041662544.1|3605538_3607230_+|bifunctional-3'-5'-exonuclease/DNA-polymerase
MSERWALAAEAEGDGALLVPLGPDGLPAGDVRREPDLVAAVRARPEVSRWVWRSTAEVYPRLLAAGVRVERCYDIEDAEQLLLGHEGRLGEPRSAAAAWARLRNAPVPPDPPQRTAEPGSQDSLFEPRPVVSVPFDGLLTVYAEQLRRHDRAEHPGRMRLLTAAESAGMLVAAEMHRAGLPWRADVHRDLLNELLGERYAGGGEPRRLAELADQVSAAFGRRVRPDLPADVVKAFAQAGVRLKSTRRWELAELDHPAVEPLIAYKKLYRIWTAHGWSWLQDWVRDGRFRPEYLPGGTVSGRWTTNGGGALQIPKVIRRAVVADDGWRLVVADADQMEPRVLAAISRDPGLMEVAGHPDDLYTRLSDRAFSGDRDHAKIALLGAIYGQTSGDGLKNLAALRRRFPRAVAYVDEAAKAGEEGRLVRTWLGRTSPRAVGAGEAEEAGLPQEGGEQPAEEGEFVPGYASGNARARGRFTRNFVVQGSAADWALLMLAALRRSLAGMRAELVFFQHDEVIVHCPAEEAEAVTAAIRAAGDEAGRIAFGETPVRFPFTTATVERYADAK
>NZ_CP029197.1|WP_015034493.1|3607341_3608649_-|hypothetical-protein
MSQHDGSQHERFEEELGAVLRRTGDGFAAGDRRELVAGGLQRGRRRLLRRRLAVTGGVLALAAVGVGGVYGGSLLSAGDAANASVAAPPKPLTNTTPASSTTPKAGLGEKGDHVPQIPVKDIAAVLKKNTPQGTWAFDSLDGNGQSVAGVFDDGHGKAAVTVGLYRAGAVEAGEDQVDCPDKVAVPYDSCTEQNLPNGSRLMILQGYEYPDKREETKNWRAVLLTKDGFLVDASEYNAAAEKGSPVTRENPPFSPAQLKTLVTSRDWRPLLVKLPRYTEPAVDPGTSGLPPEPSGPAMQATLRSLLPKGLKVVDKNQDSGYAHMVVDDGKGKSLVGVNVQPDMSDVADELFGSGDVTTLPDGRRVKLTQQPGEKGGAGVVWWSVDTITPEGFRVVVSAFNSGAQHEAATRPEPALTMAQLKAIALSLKWQNVPMR

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Crispr_ID: NZ_CP029197_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_16

4465583-4465650

Orphan

Consensus_repeat	Method
CAGGTCCTGCGCCTCGTCGAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_16

>merge|NZ_CP029197|16|4465583-4465650|CRISPRCasFinder
CAGCTTCTGCTCGTCCTCGTCGAACAGCCCCTCGGCGTGCTCCGCGAGGAACTCCGCGTCGCCGAGCA

>NZ_CP029197|16|14|4465583-4465650|CRISPRCasFinder
CAGCTTCTGCTCGTCCTCGTCGA	ACAGCCCCTCGGCGTGCTCCGC
GAGGAACTCCGCGTCGCCGAGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015035314.1\|4456200_4457112_-\|M56-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320685
NZ_CP029197.1\|WP_041662731.1\|4462729_4463656_+\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270704
NZ_CP029197.1\|WP_015035320.1\|4461972_4462662_+\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|281866
NZ_CP029197.1\|WP_015035329.1\|4473463_4474306_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP029197.1\|WP_015035325.1\|4467259_4468900_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP029197.1\|WP_015035330.1\|4474302_4475370_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP029197.1\|WP_015035322.1\|4463652_4464225_-\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NZ_CP029197.1\|WP_015035328.1\|4472261_4473359_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP029197.1\|WP_015035317.1\|4457988_4460256_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP029197.1\|WP_041662733.1\|4467067_4467256_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_071891443.1\|4477137_4477449_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041662734.1\|4476523_4477150_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP029197.1\|WP_015035327.1\|4469663_4472156_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|379300
NZ_CP029197.1\|WP_071891440.1\|4469032_4469611_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NZ_CP029197.1\|WP_015035331.1\|4475366_4476371_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464
NZ_CP029197.1\|WP_015035323.1\|4464311_4464794_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319906
NZ_CP029197.1\|WP_041664095.1\|4457108_4457498_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP029197.1\|WP_015035318.1\|4460474_4460759_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NZ_CP029197.1\|WP_015035319.1\|4460943_4461921_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015035316.1\|4457669_4457951_-\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015035314.1\|4456200_4457112_-\|M56-family-metallopeptidase	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	1.00409e-28
NZ_CP029197.1\|WP_041662731.1\|4462729_4463656_+\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|270704	cd05155, APH_ChoK_like_1, Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase. This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	4.7783e-95
NZ_CP029197.1\|WP_015035320.1\|4461972_4462662_+\|copper-homeostasis-protein-CutC	gnl\|CDD\|281866	pfam03932, CutC, CutC family. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	7.03004e-25
NZ_CP029197.1\|WP_015035329.1\|4473463_4474306_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	4.16203e-132
NZ_CP029197.1\|WP_015035325.1\|4467259_4468900_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	2.2161e-108
NZ_CP029197.1\|WP_015035330.1\|4474302_4475370_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	1.334e-76
NZ_CP029197.1\|WP_015035318.1\|4460474_4460759_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	5.74662e-14
NZ_CP029197.1\|WP_015035328.1\|4472261_4473359_+\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	1.23145e-05
NZ_CP029197.1\|WP_015035317.1\|4457988_4460256_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP029197.1\|WP_041662734.1\|4476523_4477150_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.03321e-27
NZ_CP029197.1\|WP_015035327.1\|4469663_4472156_-\|DNA-binding-protein	gnl\|CDD\|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	2.54395e-40
NZ_CP029197.1\|WP_015035331.1\|4475366_4476371_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	1.54464e-80
NZ_CP029197.1\|WP_015035323.1\|4464311_4464794_-\|glyoxalase	gnl\|CDD\|319906	cd07242, VOC_BsYqjT, vicinal oxygen chelate (VOC) family protein similar to Bacillus subtilis YqjT. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	5.13606e-38
NZ_CP029197.1\|WP_041664095.1\|4457108_4457498_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	4.55573e-27
NZ_CP029197.1\|WP_015035322.1\|4463652_4464225_-\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	9.1291e-32
NZ_CP029197.1\|WP_071891440.1\|4469032_4469611_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	2.04889e-19
NZ_CP029197.1\|WP_015035316.1\|4457669_4457951_-\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	1.99109e-29

>NZ_CP029197.1|WP_015035323.1|4464311_4464794_-|glyoxalase
MSPAGALHHVEVWVGDLARAEDSFGWLLGALGYEPFQRWEGGRSWALGSFYLVVEQSAARTSDVHDRLRPGLNHLAFHAGDRTAVDALVAEAPAHGWRLLFADRHPYAGGEGVYAAYLENADGFEVELVAAPEEPGERGEPEEPGESGEPGAPREDAGER
>NZ_CP029197.1|WP_015035322.1|4463652_4464225_-|dihydrofolate-reductase-family-protein
MRTLISSAFVSLDGVMEAPGGEEGYRNAGWTFKDVEFVPEAYAIKGREQEEAAAMLFGRASYEAFSAVWPDMEDFARYKTLPKYVVSTTLTEDGLADNWGETTILRSLDEVAALKETEGGPIIMHGSASLGRALSDAGLIDRYHLLVFPLLLGAGKRLFSGTDKDTQKLKLVEHETYANGIQKNVFDVVR
>NZ_CP029197.1|WP_041662731.1|4462729_4463656_+|aminoglycoside-phosphotransferase-family-protein
MAVISPPASPEGPVGVEFVGRLVAGRFPEWGGLPVRAVPSAGTDNVMFRLGDDLVVRLPRVAYAARHVEKEQRWLPLLAPHLPLAVPVPVGRAEPGPEFPYPWSVYRWLDGDDTYNAPLTDLAHAAVELGRFGAALRAVDASDGPASFRGGPVTAWEEGQLPAAVRDLAADGLVDAGLATAAWEAVLRLPQWDGPPVWVHGDLLPGNLLGRGGRLSAVIDFGGLGTGDPACDTLPAWTLFTAATRPLFREAARVDDATWARGRGWALAWGLVTEHHYRGRNEVLAAVARRTRTEALAEYAELAGATAS
>NZ_CP029197.1|WP_015035320.1|4461972_4462662_+|copper-homeostasis-protein-CutC
MSNRAVLEVIALDEEDAVAAQTGGADRLELVTDMAADGLTPSRTGFAAIRAAVDIPLRVMLRLTDGFAAGDVDALVARAQELRAAGADEFVLGFLTAEGEPDLVAVERLIAVLDGCRWTFHRAIDRAADRDGLRKRLADLPGLDTYLTAGSATGVDDGLATLKAEAARRGEPGYEAQILVGGGLRLDHLPELRAAGLDAFHIGGAARPHGWTSPVSAAAVRAWREALDG
>NZ_CP029197.1|WP_015035319.1|4460943_4461921_+|hypothetical-protein
MNTGVKITAFAAALAATFGTAYGVGKGVGPVEEPKKAEHGDHAAAPTPTGSTAADGHAGHGAQTPETGTAAELPGGLQISQDGYTLALETPVPAAGKSVLKFSIKDAAGRKVTAFTTEHGKELHFIVASRDLNTFRHLHPVKAADGTWSVDADLPAAGGYKAFADFKPAAPGAKGVTLGADLSVPGAYAPKPLPAVAPTATVDGYQVRLGGVLDPGKAGELKLTVTKGGKPVTDLEPYLGAYGHLVALRDGDLAYLHVHPNEGGPGPDVSFTATAPSAGTYRLFLDFQHEGKVRTASFTVTTGGGNASVPATGEATHDAGGHAHG
>NZ_CP029197.1|WP_015035318.1|4460474_4460759_-|heavy-metal-associated-domain-containing-protein
MGSCCTPDNSCSTTAETTAVAVADSTTTVYAVSGMTCGHCKTAITKSVSALDGVISVDVDVAGGLVTVTTGGEPDDAAITAAVDDAGYELTGRA
>NZ_CP029197.1|WP_015035317.1|4457988_4460256_-|copper-translocating-P-type-ATPase
MTTTTPGTAQVELAIGGMTCASCAARIEKKLNRMDGVEATVNYATEKAKVTFDADIDVADLIATVEATGYTAAEPAPPRSETPGAPDGPSDEERADEELRPLKQRLITAVALAVPVIAMAMVPALQIEYWQWLSLTLAAPVVVYAAWPFHRAAWTNARHGAATMDTLISVGTIAAFLWSLWALFFGTAGTPGMTHPFEFTIARTDGAGNIYLEAAAGVTAFILAGRYFEARSKRKAGAALKALMQLGAKEVTVLKDGREVTVPTGELQVGDRFLVRPGEKIATDGTVVEGSSAVDASMLTGESVPVEVSVGDSVTGATLNAGGRLVVEATRVGSDTQLARMAKLVEDAQNGKAAAQRLADRISAVFVPIVIALALGTLGFWLGTGQGLTAAFTAAVAVLIIACPCALGLATPTALMVGTGRGAQLGILIKGPEVLETTRKVDTIVLDKTGTVTTGRMTLLKVHTAEGTDETDVLRLAGALEHSSEHPIAQAVATGATAKVGTLPTPEDFANIPGLGVQGVVEGHAVLVGREKLLDEWAMALPADLKSAKETAEKAGKTAIAVAWDGEARAVLEVADAVKETSAEAIRRLRGLGLTPILLTGDNEAVARAVAAEVGIDEVIAEVMPQDKVDVVKKLQAEGRSVAMVGDGVNDAAALAQADLGLAMGTGTDAAIEAGDLTLVRGDLRAAADAIRLSRRTLGTIRSNLFWAFAYNVAALPLAAAGLLNPMIAGAAMAFSSVFVVGNSLRLRGFQAADR
>NZ_CP029197.1|WP_015035316.1|4457669_4457951_-|metal-sensitive-transcriptional-regulator
MAGYGQHKEDIIRRLRRIEGQVRGVQRMVDEDVYCIDVLTQVSAINAALQSCAVALLDEHLSCCVTEAIAQGGDQAKVKVGEASKAIARLIRT
>NZ_CP029197.1|WP_041664095.1|4457108_4457498_-|BlaI/MecI/CopY-family-transcriptional-regulator
MRRLGELEAEIMDRLWAWQRPATVREVVDDINRGRRVAYTTVMTVADILHRKGWLRREKAGRAWLYEPVRSREEYTAGLMRDALGDSQDRPAALLRFVEVISDEDMDALDAALRAARGDQEPHPGGSAA
>NZ_CP029197.1|WP_015035314.1|4456200_4457112_-|M56-family-metallopeptidase
MNHHLLVPLGVVALTGFLVPWLVVRARWAQQAPRLALAVWAACGALFAAATALVPAQLVLPIESSHRLADMMYALRPPTVGQLLHLDGRERFAFALSLAVLSLPAAAFVHRLARARRVRVRHAGVLRLVGRYDPALRATVLDDDRPAVYCLPGRSRPIVVSSGAVDTLTPAQLAAALAHERAHISGRHHLLVAATEAFTAVFARLPLARHGGAAVPLLLEMAADDRALRRCTRDALATALYALASGRAPRSAFAAGGPSAALRMRRILTPHSAGHPVLRGLLTVGAAGLAITPLIVACCSFPG
>NZ_CP029197.1|WP_041662733.1|4467067_4467256_+|hypothetical-protein
MTATTFTLVTTVPRPRVRPLGTALRALRAFGGAAAGVVLLGDYGPPRAGVRNPRPVYAPGPD
>NZ_CP029197.1|WP_015035325.1|4467259_4468900_-|DEAD/DEAH-box-helicase
MSGPLIVQSDKTLLLEVDHELADDCRRAIAPFAELERAPEHIHTYRLTPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMDRYGRLTLSKHPAHGLVLTSTDRPVLEEILRSRKVQPLVGERIDPDTVVVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHRIDLAEDGWALRPYQKQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAQAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTKRKGIYPHLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAEAEEKYRFCATTATKRKVTEALVKKFEGQQILVIGQYIDQLDELGEHLDAPVIKGETPNAQREKLFDAFRTGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHQAHFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADELLGS
>NZ_CP029197.1|WP_071891440.1|4469032_4469611_+|Uma2-family-endonuclease
MSVAHDPHYGPWTIEEVLALPEDRGQRRELMGEALVMSPAPGTKHQRASSRLWSLLDRALQSEGVPAEVLEAVNLILPDGLFIPDIVVVEAAAAAENPVTYDADDVLLVVEIVSPSSSGRRTDRLLKPPYYAEAGIEHLWRLELEPVPTLVVCELQDGRYVERTVAEAGRTTLIEKPFPLEVDPAALVSPRT
>NZ_CP029197.1|WP_015035327.1|4469663_4472156_-|DNA-binding-protein
MPEVSGAAAAPRTLAEALRARGDEGLAALLRARPDLLNPVPNDLTQLATRAGTRGSVVRALERLDRFALQTAEALAVAPDPAPYPVLLGLLTGDEGDPEIEAALPGAVALLREQALVWGEDDRLRLVRTARELLAPSAQHPSPTGLGPTVAEATSGMSPGRVQEIIAAAGLSATHDAVSAVAALTALFTDRARMGALLDTAPPEALAVLDRLVWGPPYGEVTAKPAAPVQWLRDHGLLLPVSPRTMVLPREVALHLRGGRAHRSPEPRAPEPAVLREYRPQVVDSAAAGQAQLALATVEELLKSWDRGGPPVLRAGGLAVRDLKRTAAALDVSEETAAFWLELCYGAGLLASDGEADERYAPTPAYDDWLDLPPAERWALLVTPWLSATRTPGLVGGQDAKGRALSALGPDLDRAPAPEVRHRVLGLLATLPPGSAVEPESLFARLRWERPLRGAAAAGDGDDLRSRLARWTLAEAELLGLTGRGALSGPARALLNLPLAEAASPGEPGGGVEPAVAAGRAATLLAPLLPEAVDHVLLQADLTAVAPGPLRRPLADALAVLADVESKGGATVYRFTPGSVRRALDSGQTATDLHEFLKAHARTPVPQPLTYLVDDVARRHGHLRVGAASAYVRCDDDTVLGEILADRRSSSLGLRRLAPTVLAAQTDPASLLEGLRSMGYAPAAESATGDVLITRADAYRTPARTAPVPVPDGPPAPDTTLLGAAVRAIRAGDRAATAVRKEPAAAPTAAGALPRTSAAETLATVQAAAMTGSAVWIGYVNAEGGASQRVIAPVRVEGGFVTAYDHTADEVRTYPLHRITGVAELADDQV
>NZ_CP029197.1|WP_015035328.1|4472261_4473359_+|hypothetical-protein
MGIESDQLVYDYLSRVGDLAQQRQLPASERMRLVSTLRNEIDRRRATYGEESPAAVRRILGTLGTPDEVVERAEGPGAPPAPSAPAPAPVPKPRKEGRPGRAGRAAGWLPGSRRSREGSGKPKSAPRTPAPGASAPVASVSGAPAGADAPAASDLTGLDATGGLLDDTSDWWQQEDPAEGLPGFVGGVERPDLFEEPVPDEDEHEDGEGDEEDDAEAPSRGRRLARVLLRRKPRAAAEAYGTEEEPDAAPVSRLRLANPFVLLAALLLLGGALFGSPVVLALGWLLAYGSRRLTPGEVKAAVLVIPGLAAASGVVWLWGRVEGRWGDPVGAGGEAMGAAVSETWPWALRGAAVASALFLIWRSRR
>NZ_CP029197.1|WP_015035329.1|4473463_4474306_-|ABC-transporter-ATP-binding-protein
MSRLTARELTLAYEDRTVVHELDLAIPDGKVTVIVGPNACGKSTTLRALGRLLRPAGGAVLLDGEELAKLPTKRIARSIGLLPQTPVAPEAITVADLVSRGRQPHQAWWKQWSEEDERAVTEAMDRTDVAALADRSVDELSGGQRQRVWIAMALAQETDLLLLDEPTTYLDISHQVEVLDLVRRLNRLRGRTVVVVLHDLNQAARYADHLVAMKAGRVVAEGPPSEIVTEQLVRDVFGLSSVVVPDPVTGSPLVVPGAPWEGDGAGAGAVTSAGTDTVKG
>NZ_CP029197.1|WP_015035330.1|4474302_4475370_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTAPTLVRPAGYGTVRAGRASFLVHRRSALVAVGLLLLLAASSVAYLCVGERFVGPSEVLRVLLGQPSPSAFVVAELREPRLVVALAVGAAFGVAGALIQTVARNPLASPDIIGISQGAGAVTVAAMTFGLTSYTVLPYLSIAGGVLAAALVYAFAWRGGLHATRFVLIGIGFAIALRSLTTLFMTKGDYLVAQQAQIWMTGSLNGRGWDESAPIRWTLLLMLPAVLWAARAQRTVSLDDDTATALGVRLGPVRLGLVAVGVVLASVATGVAGPVDFVALLAPQIARRMTRTAQIPLLCSALAGAVVVVLADLVGRRLFSPVELPVGVLTAAVGAPYLIWLIVRSRAAGSSGGKA
>NZ_CP029197.1|WP_015035331.1|4475366_4476371_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MPAAFRTRRVLATSAALVALLVAVLLSLAVGARAIAPTTVLDALLHGGTSPDAEVVRQLRVPRTVIGLMVGAALALAGTALQGITRNPIADPGILGLSQGSSVGVVLAIAFFGVHTLTGYVWFAFAGAALAAVAVHAVASSGRGGATPVKLALGGAAINALLLSVTTGILTTRASALDEFRFWQIGSLDGRDAQIVGQIWPFLLVGAVLVVSVARGLDALALGEDVAKGLGQRVATVRIVGGVGATVLTGAGVAAAGPVAFVGLAVPHIARAVVGSDHRWVLPMAAIIGPVMLLVADVAGRIVFPPGEVPAGVMTALIGVPFLVTLVRRKAVPA
>NZ_CP029197.1|WP_041662734.1|4476523_4477150_+|HAD-family-hydrolase
MTTSATRPPLTVGFDLDLTLIDTRPGIRAAWVAFSAESGVPVDADLVVSRLGPPLEHEMAYWVPEERVTEMVARYRALYPAYAIEPSAPMPGARDAIRAVREAGGRTIVVTAKNGPHAELHLAHLGIEPDAVVGGLWAEGKAEALRAHGAQVYVGDHVGDVRGAATAGALSVAVATGPCAPEELKEAGADVVLPDLTDFRSWWEGYLA
>NZ_CP029197.1|WP_071891443.1|4477137_4477449_-|hypothetical-protein
MFLRPGNYPGRMRSETPAAPANDSAPGDGLIKAGVILFAVGAVATLVTVAPLFLGTDPFPTVAYTVSMLMGVGFAVAAAGVLRSIAAQRRQARSGSTGPVQAR

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Crispr_ID: NZ_CP029197_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_15

4465442-4465519

Orphan

Consensus_repeat	Method
CAGGTCCTGCGCCTCGTCGAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_15

>merge|NZ_CP029197|15|4465442-4465519|CRISPRCasFinder
CAGGTCCTGCGCCTCGTCGAGGACCACGTGCCCGAGCGAGTGCGTCCGCTCCACCAGGTCCTGCGCCTCGTCGATGAG

>NZ_CP029197|15|13|4465442-4465519|CRISPRCasFinder
CAGGTCCTGCGCCTCGTCGAGGA	CCACGTGCCCGAGCGAGTGCGTCCGCTCCAC
CAGGTCCTGCGCCTCGTCGATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015035314.1\|4456200_4457112_-\|M56-family-metallopeptidase	unknown	unknown	gnl\|CDD\|320685
NZ_CP029197.1\|WP_041662731.1\|4462729_4463656_+\|aminoglycoside-phosphotransferase-family-protein	unknown	unknown	gnl\|CDD\|270704
NZ_CP029197.1\|WP_015035320.1\|4461972_4462662_+\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|281866
NZ_CP029197.1\|WP_015035329.1\|4473463_4474306_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP029197.1\|WP_015035325.1\|4467259_4468900_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP029197.1\|WP_015035330.1\|4474302_4475370_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP029197.1\|WP_015035322.1\|4463652_4464225_-\|dihydrofolate-reductase-family-protein	unknown	unknown	gnl\|CDD\|334719
NZ_CP029197.1\|WP_015035328.1\|4472261_4473359_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237057
NZ_CP029197.1\|WP_015035317.1\|4457988_4460256_-\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319783
NZ_CP029197.1\|WP_041662733.1\|4467067_4467256_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_071891443.1\|4477137_4477449_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041662734.1\|4476523_4477150_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223620
NZ_CP029197.1\|WP_015035327.1\|4469663_4472156_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|379300
NZ_CP029197.1\|WP_071891440.1\|4469032_4469611_+\|Uma2-family-endonuclease	unknown	unknown	gnl\|CDD\|368559
NZ_CP029197.1\|WP_015035331.1\|4475366_4476371_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464
NZ_CP029197.1\|WP_015035323.1\|4464311_4464794_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319906
NZ_CP029197.1\|WP_041664095.1\|4457108_4457498_-\|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367747
NZ_CP029197.1\|WP_015035318.1\|4460474_4460759_-\|heavy-metal-associated-domain-containing-protein	unknown	unknown	gnl\|CDD\|225328
NZ_CP029197.1\|WP_015035319.1\|4460943_4461921_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015035316.1\|4457669_4457951_-\|metal-sensitive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197385

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015035314.1\|4456200_4457112_-\|M56-family-metallopeptidase	gnl\|CDD\|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	1.00409e-28
NZ_CP029197.1\|WP_041662731.1\|4462729_4463656_+\|aminoglycoside-phosphotransferase-family-protein	gnl\|CDD\|270704	cd05155, APH_ChoK_like_1, Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase. This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	4.7783e-95
NZ_CP029197.1\|WP_015035320.1\|4461972_4462662_+\|copper-homeostasis-protein-CutC	gnl\|CDD\|281866	pfam03932, CutC, CutC family. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	7.03004e-25
NZ_CP029197.1\|WP_015035329.1\|4473463_4474306_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	4.16203e-132
NZ_CP029197.1\|WP_015035325.1\|4467259_4468900_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	2.2161e-108
NZ_CP029197.1\|WP_015035330.1\|4474302_4475370_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	1.334e-76
NZ_CP029197.1\|WP_015035318.1\|4460474_4460759_-\|heavy-metal-associated-domain-containing-protein	gnl\|CDD\|225328	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism].	5.74662e-14
NZ_CP029197.1\|WP_015035328.1\|4472261_4473359_+\|hypothetical-protein	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	1.23145e-05
NZ_CP029197.1\|WP_015035317.1\|4457988_4460256_-\|copper-translocating-P-type-ATPase	gnl\|CDD\|319783	cd02094, P-type_ATPase_Cu-like, P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B. The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP029197.1\|WP_041662734.1\|4476523_4477150_+\|HAD-family-hydrolase	gnl\|CDD\|223620	COG0546, Gph, Predicted phosphatases [General function prediction only].	2.03321e-27
NZ_CP029197.1\|WP_015035327.1\|4469663_4472156_-\|DNA-binding-protein	gnl\|CDD\|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	2.54395e-40
NZ_CP029197.1\|WP_015035331.1\|4475366_4476371_-\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	1.54464e-80
NZ_CP029197.1\|WP_015035323.1\|4464311_4464794_-\|glyoxalase	gnl\|CDD\|319906	cd07242, VOC_BsYqjT, vicinal oxygen chelate (VOC) family protein similar to Bacillus subtilis YqjT. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	5.13606e-38
NZ_CP029197.1\|WP_041664095.1\|4457108_4457498_-\|BlaI/MecI/CopY-family-transcriptional-regulator	gnl\|CDD\|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	4.55573e-27
NZ_CP029197.1\|WP_015035322.1\|4463652_4464225_-\|dihydrofolate-reductase-family-protein	gnl\|CDD\|334719	pfam01872, RibD_C, RibD C-terminal domain. The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C-terminus of RibD/RibG, in combination with pfam00383, as well as in isolation in some archaebacterial proteins. This family appears to be related to pfam00186.	9.1291e-32
NZ_CP029197.1\|WP_071891440.1\|4469032_4469611_+\|Uma2-family-endonuclease	gnl\|CDD\|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	2.04889e-19
NZ_CP029197.1\|WP_015035316.1\|4457669_4457951_-\|metal-sensitive-transcriptional-regulator	gnl\|CDD\|197385	cd10148, CsoR-like_DUF156, Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156. This superfamily includes various transcriptional regulators that respond to stressors including Cu(I), Ni(I), sulfite, and formaldehyde. It includes CsoR (copper-sensitive operon repressor) from Mycobacterium tuberculosis (MtCsoR), Bacillus subtilis (BsCsoR), Thermus thermophilus (TthCsoR), and Staphylococcus aureus (SaCsoR), Mycobacterium tuberculosis RicR (regulated in copper repressor, MtRicR), Escherichia coli RncR (formally known as YohL, nickel and cobalt-sensitive), Alcaligenes xylosoxidans NreA (nickel-sensitive), E. coli FrmR (formally known as YaiN, formaldehyde sensitive), and Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor, NWMN_0026.5, SaCstR). CsoR is Cu(I)-inducible, and regulates the expression of genes involved in copper homeostasis. For example, TthCsoR binds the promoter region of the copZ-csoR-copA operon, and represses expression of these genes, which encode the copper chaperone CopZ, CsoR, and the copper efflux P-type ATPase CopA, respectively. In the presence of excess Cu(I), TthCsoR binds this ion, and is released from the DNA, allowing expression of the downstream genes. TthCsoR also senses other metal ions such as Cu(II), Zn(II), Ag(I), Cd(II) and Ni(II). CsoRs form a homotetramer (dimer of dimers). In the case of MtCsoR, two Cys residues on opposite subunits within each dimer, along with a His residue, bind the Cu(I) ion. These residues are conserved in the majority of members of this superfamily. Exceptions include the functionally uncharacterized Bacillus subtilis YrkD where there is an Asn instead of His (C-N-C), E.coli RcnR where there is a Thr instead of the second Cys (C-H-T), or TthCsoR and E.coli FrmR where there is a His instead of the second Cys and which have an additional N-terminal His (not found in those family members having C-H-C) that may also be involved in metal binding (H-C-H-H). A conserved Tyr and a Glu residue facilitate allosteric regulation of DNA binding. SaCstR regulates genes predicted to function in sulfur metabolism; it is thought that oxidation of the intersubunit Cys pair to a mixture of disulphide and trisulphide linkages by sulfite, results in a reduced affinity of SaCstR for the operator DNA. SaCstR exists as a mixture of oligomeric states, including dimers, tetramers and octamers. The sequence of SaCstR was not available at the time this hierarchy was curated and therefore was not included. Escherichia coli RncR represses expression of the gene encoding the nickel and cobalt-efflux protein RcnA. The gene encoding Alcaligenes xylosoxidans NreA is part of the nre nickel resistance locus located on the pTOM9 plasmid from thisbacteria. Escherichia coli FrmR regulates the formaldehyde degradation frmRAB operon.	1.99109e-29

>NZ_CP029197.1|WP_015035323.1|4464311_4464794_-|glyoxalase
MSPAGALHHVEVWVGDLARAEDSFGWLLGALGYEPFQRWEGGRSWALGSFYLVVEQSAARTSDVHDRLRPGLNHLAFHAGDRTAVDALVAEAPAHGWRLLFADRHPYAGGEGVYAAYLENADGFEVELVAAPEEPGERGEPEEPGESGEPGAPREDAGER
>NZ_CP029197.1|WP_015035322.1|4463652_4464225_-|dihydrofolate-reductase-family-protein
MRTLISSAFVSLDGVMEAPGGEEGYRNAGWTFKDVEFVPEAYAIKGREQEEAAAMLFGRASYEAFSAVWPDMEDFARYKTLPKYVVSTTLTEDGLADNWGETTILRSLDEVAALKETEGGPIIMHGSASLGRALSDAGLIDRYHLLVFPLLLGAGKRLFSGTDKDTQKLKLVEHETYANGIQKNVFDVVR
>NZ_CP029197.1|WP_041662731.1|4462729_4463656_+|aminoglycoside-phosphotransferase-family-protein
MAVISPPASPEGPVGVEFVGRLVAGRFPEWGGLPVRAVPSAGTDNVMFRLGDDLVVRLPRVAYAARHVEKEQRWLPLLAPHLPLAVPVPVGRAEPGPEFPYPWSVYRWLDGDDTYNAPLTDLAHAAVELGRFGAALRAVDASDGPASFRGGPVTAWEEGQLPAAVRDLAADGLVDAGLATAAWEAVLRLPQWDGPPVWVHGDLLPGNLLGRGGRLSAVIDFGGLGTGDPACDTLPAWTLFTAATRPLFREAARVDDATWARGRGWALAWGLVTEHHYRGRNEVLAAVARRTRTEALAEYAELAGATAS
>NZ_CP029197.1|WP_015035320.1|4461972_4462662_+|copper-homeostasis-protein-CutC
MSNRAVLEVIALDEEDAVAAQTGGADRLELVTDMAADGLTPSRTGFAAIRAAVDIPLRVMLRLTDGFAAGDVDALVARAQELRAAGADEFVLGFLTAEGEPDLVAVERLIAVLDGCRWTFHRAIDRAADRDGLRKRLADLPGLDTYLTAGSATGVDDGLATLKAEAARRGEPGYEAQILVGGGLRLDHLPELRAAGLDAFHIGGAARPHGWTSPVSAAAVRAWREALDG
>NZ_CP029197.1|WP_015035319.1|4460943_4461921_+|hypothetical-protein
MNTGVKITAFAAALAATFGTAYGVGKGVGPVEEPKKAEHGDHAAAPTPTGSTAADGHAGHGAQTPETGTAAELPGGLQISQDGYTLALETPVPAAGKSVLKFSIKDAAGRKVTAFTTEHGKELHFIVASRDLNTFRHLHPVKAADGTWSVDADLPAAGGYKAFADFKPAAPGAKGVTLGADLSVPGAYAPKPLPAVAPTATVDGYQVRLGGVLDPGKAGELKLTVTKGGKPVTDLEPYLGAYGHLVALRDGDLAYLHVHPNEGGPGPDVSFTATAPSAGTYRLFLDFQHEGKVRTASFTVTTGGGNASVPATGEATHDAGGHAHG
>NZ_CP029197.1|WP_015035318.1|4460474_4460759_-|heavy-metal-associated-domain-containing-protein
MGSCCTPDNSCSTTAETTAVAVADSTTTVYAVSGMTCGHCKTAITKSVSALDGVISVDVDVAGGLVTVTTGGEPDDAAITAAVDDAGYELTGRA
>NZ_CP029197.1|WP_015035317.1|4457988_4460256_-|copper-translocating-P-type-ATPase
MTTTTPGTAQVELAIGGMTCASCAARIEKKLNRMDGVEATVNYATEKAKVTFDADIDVADLIATVEATGYTAAEPAPPRSETPGAPDGPSDEERADEELRPLKQRLITAVALAVPVIAMAMVPALQIEYWQWLSLTLAAPVVVYAAWPFHRAAWTNARHGAATMDTLISVGTIAAFLWSLWALFFGTAGTPGMTHPFEFTIARTDGAGNIYLEAAAGVTAFILAGRYFEARSKRKAGAALKALMQLGAKEVTVLKDGREVTVPTGELQVGDRFLVRPGEKIATDGTVVEGSSAVDASMLTGESVPVEVSVGDSVTGATLNAGGRLVVEATRVGSDTQLARMAKLVEDAQNGKAAAQRLADRISAVFVPIVIALALGTLGFWLGTGQGLTAAFTAAVAVLIIACPCALGLATPTALMVGTGRGAQLGILIKGPEVLETTRKVDTIVLDKTGTVTTGRMTLLKVHTAEGTDETDVLRLAGALEHSSEHPIAQAVATGATAKVGTLPTPEDFANIPGLGVQGVVEGHAVLVGREKLLDEWAMALPADLKSAKETAEKAGKTAIAVAWDGEARAVLEVADAVKETSAEAIRRLRGLGLTPILLTGDNEAVARAVAAEVGIDEVIAEVMPQDKVDVVKKLQAEGRSVAMVGDGVNDAAALAQADLGLAMGTGTDAAIEAGDLTLVRGDLRAAADAIRLSRRTLGTIRSNLFWAFAYNVAALPLAAAGLLNPMIAGAAMAFSSVFVVGNSLRLRGFQAADR
>NZ_CP029197.1|WP_015035316.1|4457669_4457951_-|metal-sensitive-transcriptional-regulator
MAGYGQHKEDIIRRLRRIEGQVRGVQRMVDEDVYCIDVLTQVSAINAALQSCAVALLDEHLSCCVTEAIAQGGDQAKVKVGEASKAIARLIRT
>NZ_CP029197.1|WP_041664095.1|4457108_4457498_-|BlaI/MecI/CopY-family-transcriptional-regulator
MRRLGELEAEIMDRLWAWQRPATVREVVDDINRGRRVAYTTVMTVADILHRKGWLRREKAGRAWLYEPVRSREEYTAGLMRDALGDSQDRPAALLRFVEVISDEDMDALDAALRAARGDQEPHPGGSAA
>NZ_CP029197.1|WP_015035314.1|4456200_4457112_-|M56-family-metallopeptidase
MNHHLLVPLGVVALTGFLVPWLVVRARWAQQAPRLALAVWAACGALFAAATALVPAQLVLPIESSHRLADMMYALRPPTVGQLLHLDGRERFAFALSLAVLSLPAAAFVHRLARARRVRVRHAGVLRLVGRYDPALRATVLDDDRPAVYCLPGRSRPIVVSSGAVDTLTPAQLAAALAHERAHISGRHHLLVAATEAFTAVFARLPLARHGGAAVPLLLEMAADDRALRRCTRDALATALYALASGRAPRSAFAAGGPSAALRMRRILTPHSAGHPVLRGLLTVGAAGLAITPLIVACCSFPG
>NZ_CP029197.1|WP_041662733.1|4467067_4467256_+|hypothetical-protein
MTATTFTLVTTVPRPRVRPLGTALRALRAFGGAAAGVVLLGDYGPPRAGVRNPRPVYAPGPD
>NZ_CP029197.1|WP_015035325.1|4467259_4468900_-|DEAD/DEAH-box-helicase
MSGPLIVQSDKTLLLEVDHELADDCRRAIAPFAELERAPEHIHTYRLTPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMDRYGRLTLSKHPAHGLVLTSTDRPVLEEILRSRKVQPLVGERIDPDTVVVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHRIDLAEDGWALRPYQKQAVEGFWHGGSGVVVLPCGAGKTLVGAGAMAQAKATTLILVTNTVSARQWKHELVKRTSLTEDEIGEYSGTKKEIRPVTIATYQVLTTKRKGIYPHLELFDSRDWGLIVYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDSERLAYATAEAEEKYRFCATTATKRKVTEALVKKFEGQQILVIGQYIDQLDELGEHLDAPVIKGETPNAQREKLFDAFRTGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHQAHFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADELLGS
>NZ_CP029197.1|WP_071891440.1|4469032_4469611_+|Uma2-family-endonuclease
MSVAHDPHYGPWTIEEVLALPEDRGQRRELMGEALVMSPAPGTKHQRASSRLWSLLDRALQSEGVPAEVLEAVNLILPDGLFIPDIVVVEAAAAAENPVTYDADDVLLVVEIVSPSSSGRRTDRLLKPPYYAEAGIEHLWRLELEPVPTLVVCELQDGRYVERTVAEAGRTTLIEKPFPLEVDPAALVSPRT
>NZ_CP029197.1|WP_015035327.1|4469663_4472156_-|DNA-binding-protein
MPEVSGAAAAPRTLAEALRARGDEGLAALLRARPDLLNPVPNDLTQLATRAGTRGSVVRALERLDRFALQTAEALAVAPDPAPYPVLLGLLTGDEGDPEIEAALPGAVALLREQALVWGEDDRLRLVRTARELLAPSAQHPSPTGLGPTVAEATSGMSPGRVQEIIAAAGLSATHDAVSAVAALTALFTDRARMGALLDTAPPEALAVLDRLVWGPPYGEVTAKPAAPVQWLRDHGLLLPVSPRTMVLPREVALHLRGGRAHRSPEPRAPEPAVLREYRPQVVDSAAAGQAQLALATVEELLKSWDRGGPPVLRAGGLAVRDLKRTAAALDVSEETAAFWLELCYGAGLLASDGEADERYAPTPAYDDWLDLPPAERWALLVTPWLSATRTPGLVGGQDAKGRALSALGPDLDRAPAPEVRHRVLGLLATLPPGSAVEPESLFARLRWERPLRGAAAAGDGDDLRSRLARWTLAEAELLGLTGRGALSGPARALLNLPLAEAASPGEPGGGVEPAVAAGRAATLLAPLLPEAVDHVLLQADLTAVAPGPLRRPLADALAVLADVESKGGATVYRFTPGSVRRALDSGQTATDLHEFLKAHARTPVPQPLTYLVDDVARRHGHLRVGAASAYVRCDDDTVLGEILADRRSSSLGLRRLAPTVLAAQTDPASLLEGLRSMGYAPAAESATGDVLITRADAYRTPARTAPVPVPDGPPAPDTTLLGAAVRAIRAGDRAATAVRKEPAAAPTAAGALPRTSAAETLATVQAAAMTGSAVWIGYVNAEGGASQRVIAPVRVEGGFVTAYDHTADEVRTYPLHRITGVAELADDQV
>NZ_CP029197.1|WP_015035328.1|4472261_4473359_+|hypothetical-protein
MGIESDQLVYDYLSRVGDLAQQRQLPASERMRLVSTLRNEIDRRRATYGEESPAAVRRILGTLGTPDEVVERAEGPGAPPAPSAPAPAPVPKPRKEGRPGRAGRAAGWLPGSRRSREGSGKPKSAPRTPAPGASAPVASVSGAPAGADAPAASDLTGLDATGGLLDDTSDWWQQEDPAEGLPGFVGGVERPDLFEEPVPDEDEHEDGEGDEEDDAEAPSRGRRLARVLLRRKPRAAAEAYGTEEEPDAAPVSRLRLANPFVLLAALLLLGGALFGSPVVLALGWLLAYGSRRLTPGEVKAAVLVIPGLAAASGVVWLWGRVEGRWGDPVGAGGEAMGAAVSETWPWALRGAAVASALFLIWRSRR
>NZ_CP029197.1|WP_015035329.1|4473463_4474306_-|ABC-transporter-ATP-binding-protein
MSRLTARELTLAYEDRTVVHELDLAIPDGKVTVIVGPNACGKSTTLRALGRLLRPAGGAVLLDGEELAKLPTKRIARSIGLLPQTPVAPEAITVADLVSRGRQPHQAWWKQWSEEDERAVTEAMDRTDVAALADRSVDELSGGQRQRVWIAMALAQETDLLLLDEPTTYLDISHQVEVLDLVRRLNRLRGRTVVVVLHDLNQAARYADHLVAMKAGRVVAEGPPSEIVTEQLVRDVFGLSSVVVPDPVTGSPLVVPGAPWEGDGAGAGAVTSAGTDTVKG
>NZ_CP029197.1|WP_015035330.1|4474302_4475370_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MTAPTLVRPAGYGTVRAGRASFLVHRRSALVAVGLLLLLAASSVAYLCVGERFVGPSEVLRVLLGQPSPSAFVVAELREPRLVVALAVGAAFGVAGALIQTVARNPLASPDIIGISQGAGAVTVAAMTFGLTSYTVLPYLSIAGGVLAAALVYAFAWRGGLHATRFVLIGIGFAIALRSLTTLFMTKGDYLVAQQAQIWMTGSLNGRGWDESAPIRWTLLLMLPAVLWAARAQRTVSLDDDTATALGVRLGPVRLGLVAVGVVLASVATGVAGPVDFVALLAPQIARRMTRTAQIPLLCSALAGAVVVVLADLVGRRLFSPVELPVGVLTAAVGAPYLIWLIVRSRAAGSSGGKA
>NZ_CP029197.1|WP_015035331.1|4475366_4476371_-|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MPAAFRTRRVLATSAALVALLVAVLLSLAVGARAIAPTTVLDALLHGGTSPDAEVVRQLRVPRTVIGLMVGAALALAGTALQGITRNPIADPGILGLSQGSSVGVVLAIAFFGVHTLTGYVWFAFAGAALAAVAVHAVASSGRGGATPVKLALGGAAINALLLSVTTGILTTRASALDEFRFWQIGSLDGRDAQIVGQIWPFLLVGAVLVVSVARGLDALALGEDVAKGLGQRVATVRIVGGVGATVLTGAGVAAAGPVAFVGLAVPHIARAVVGSDHRWVLPMAAIIGPVMLLVADVAGRIVFPPGEVPAGVMTALIGVPFLVTLVRRKAVPA
>NZ_CP029197.1|WP_041662734.1|4476523_4477150_+|HAD-family-hydrolase
MTTSATRPPLTVGFDLDLTLIDTRPGIRAAWVAFSAESGVPVDADLVVSRLGPPLEHEMAYWVPEERVTEMVARYRALYPAYAIEPSAPMPGARDAIRAVREAGGRTIVVTAKNGPHAELHLAHLGIEPDAVVGGLWAEGKAEALRAHGAQVYVGDHVGDVRGAATAGALSVAVATGPCAPEELKEAGADVVLPDLTDFRSWWEGYLA
>NZ_CP029197.1|WP_071891443.1|4477137_4477449_-|hypothetical-protein
MFLRPGNYPGRMRSETPAAPANDSAPGDGLIKAGVILFAVGAVATLVTVAPLFLGTDPFPTVAYTVSMLMGVGFAVAAAGVLRSIAAQRRQARSGSTGPVQAR

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Crispr_ID: NZ_CP029197_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_17

4536368-4536467

Orphan

Consensus_repeat	Method
CCCTCCCGCCCCACGTACCGGAGG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP029197_17

>merge|NZ_CP029197|17|4536368-4536467|CRISPRCasFinder
CCCTCCCGCCCCACGTACCGGAGGCCATCCGGTGACCGCCCTCCCGCCCGACGTACCGGAGGCCATCCGGTGACCCCCCTCCCGCCCGACGTACCGGAGG

>NZ_CP029197|17|15|4536368-4536467|CRISPRCasFinder
CCCTCCCGCCCCACGTACCGGAGG	CCATCCGGTGACCGCCCTCCCGCCCGACGTACCGGAGGCCATCCGGTGACCC
CCCTCCCGCCCGACGTACCGGAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015035385.1\|4529550_4530768_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173848
NZ_CP029197.1\|WP_015035395.1\|4542755_4543760_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP029197.1\|WP_015035397.1\|4545458_4546181_+\|enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|236109
NZ_CP029197.1\|WP_015035401.1\|4548080_4549148_+\|isopenicillin-N-synthase-family-oxygenase	unknown	unknown	gnl\|CDD\|226022
NZ_CP029197.1\|WP_015035392.1\|4540060_4541194_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP029197.1\|WP_078508901.1\|4541731_4542217_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377566
NZ_CP029197.1\|WP_078508707.1\|4533630_4534566_+\|TIGR03084-family-protein	unknown	unknown	gnl\|CDD\|274423
NZ_CP029197.1\|WP_015035398.1\|4546168_4546768_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP029197.1\|WP_015035379.1\|4525602_4526205_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP029197.1\|WP_015035389.1\|4534562_4536287_+\|DUF1446-domain-containing-protein	unknown	unknown	gnl\|CDD\|377804
NZ_CP029197.1\|WP_041662748.1\|4543869_4545462_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|341230
NZ_CP029197.1\|WP_015035381.1\|4527442_4527739_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|365891
NZ_CP029197.1\|WP_015035378.1\|4524422_4525487_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|307170
NZ_CP029197.1\|WP_015035386.1\|4531431_4532820_-\|M1-family-metallopeptidase	unknown	unknown	gnl\|CDD\|341067
NZ_CP029197.1\|WP_015035390.1\|4536474_4538076_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	unknown	unknown	gnl\|CDD\|178415
NZ_CP029197.1\|WP_041662747.1\|4542268_4542664_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|223329
NZ_CP029197.1\|WP_015035382.1\|4527735_4528509_+\|HAD-IB-family-hydrolase	unknown	unknown	gnl\|CDD\|319796
NZ_CP029197.1\|WP_051026128.1\|4538114_4540064_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP029197.1\|WP_158506265.1\|4526338_4527364_+\|gamma-butyrolactone-biosynthesis-protein	unknown	unknown	gnl\|CDD\|367638
NZ_CP029197.1\|WP_086024645.1\|4532879_4533485_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015035385.1\|4529550_4530768_+\|hypothetical-protein	gnl\|CDD\|173848	cd01159, NcnH, Naphthocyclinone hydroxylase. Naphthocyclinone is an aromatic polyketide and an antibiotic, which is active against Gram-positive bacteria. Polyketides are secondary metabolites, which have important biological functions such as antitumor, immunosupressive or antibiotic activities. NcnH is a hydroxylase involved in the biosynthesis of naphthocyclinone and possibly other polyketides.	2.04985e-82
NZ_CP029197.1\|WP_015035395.1\|4542755_4543760_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	7.74729e-43
NZ_CP029197.1\|WP_015035397.1\|4545458_4546181_+\|enoyl-CoA-hydratase-family-protein	gnl\|CDD\|236109	PRK07827, PRK07827, enoyl-CoA hydratase family protein.	1.09416e-115
NZ_CP029197.1\|WP_015035401.1\|4548080_4549148_+\|isopenicillin-N-synthase-family-oxygenase	gnl\|CDD\|226022	COG3491, PcbC, Isopenicillin N synthase and related dioxygenases [General function prediction only].	2.56641e-97
NZ_CP029197.1\|WP_015035392.1\|4540060_4541194_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.81698e-85
NZ_CP029197.1\|WP_078508901.1\|4541731_4542217_+\|hypothetical-protein	gnl\|CDD\|377566	pfam05901, Excalibur, Excalibur calcium-binding domain. Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognized and the evolution of EF-hand-like domains is probably more complex than previously appreciated.	2.98928e-16
NZ_CP029197.1\|WP_078508707.1\|4533630_4534566_+\|TIGR03084-family-protein	gnl\|CDD\|274423	TIGR03084, conserved_hypothetical_protein, TIGR03084 family protein. This family, like pfam07398, belongs to the larger set of probable enzymes modeled by TIGRFAMs family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized. [Hypothetical proteins, Conserved].	1.06865e-121
NZ_CP029197.1\|WP_015035398.1\|4546168_4546768_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.39087e-10
NZ_CP029197.1\|WP_015035379.1\|4525602_4526205_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.01523e-13
NZ_CP029197.1\|WP_015035389.1\|4534562_4536287_+\|DUF1446-domain-containing-protein	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	1.10392e-170
NZ_CP029197.1\|WP_041662748.1\|4543869_4545462_+\|AMP-binding-protein	gnl\|CDD\|341230	cd05904, 4CL, 4-Coumarate-CoA Ligase (4CL). 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.	0
NZ_CP029197.1\|WP_015035381.1\|4527442_4527739_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|365891	pfam00126, HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family.	2.88134e-19
NZ_CP029197.1\|WP_015035378.1\|4524422_4525487_+\|DMT-family-transporter	gnl\|CDD\|307170	pfam00892, EamA, EamA-like transporter family. This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.	9.82338e-11
NZ_CP029197.1\|WP_015035386.1\|4531431_4532820_-\|M1-family-metallopeptidase	gnl\|CDD\|341067	cd09604, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains bacterial M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	4.03171e-108
NZ_CP029197.1\|WP_015035390.1\|4536474_4538076_+\|acetyl-CoA-carboxylase-carboxyltransferase-subunit	gnl\|CDD\|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
NZ_CP029197.1\|WP_041662747.1\|4542268_4542664_-\|RidA-family-protein	gnl\|CDD\|223329	COG0251, TdcF, Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis].	1.2837e-20
NZ_CP029197.1\|WP_015035382.1\|4527735_4528509_+\|HAD-IB-family-hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.24976e-39
NZ_CP029197.1\|WP_051026128.1\|4538114_4540064_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP029197.1\|WP_158506265.1\|4526338_4527364_+\|gamma-butyrolactone-biosynthesis-protein	gnl\|CDD\|367638	pfam03756, AfsA, A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.	1.28945e-24

>NZ_CP029197.1|WP_015035389.1|4534562_4536287_+|DUF1446-domain-containing-protein
MTVLRIGNASGFYGDRFDAVREMLTGGGPDGAVDVLTGDYLAELTMLILGRDQLKDPAAGYAKTFLRQMEEGLGLAHDRGIRIVTNAGGLNPAGLADALRALAAKLGLPTTVAHVEGDRLPAAEGVLAANAYLGGAGIAACLAAGADVVVTGRVTDAALVTGPAQWHFGWGPEEYDKLAGAVVAGHVLECGTQATGGNYAFFREHDPALLRRPGFPLAELHEDGSAVVTKHPGTGGLVDVGTVTAQLLYETAGARYAGPDVTARLDTVRLTQEGPDRVRIDGVRGEAPPPTLKVGLSRLGGFRNEVVFVLTGLDVEEKAALVRDQVEDALAGTDARPREVRWELVRTDRPDADTEETASALLRLVVRDPAPGPVGRALTGAAIELALASYPGFHVTAPPGKGAPYGVFGTAFVPAGDVPHTAVLPDGSRVPVPIPARTRELEPVPEPALPQPLPPGPTRRVPLGRLAGARSGDKGGDANIGVWVRTDEEWRWLAHTLTVARLRELLPETAGLDVTRHVLPNLRALNFTVAGILGDGVASQARFDPQAKALGEWLRSRHTDIPAALLPDVAEDFR
>NZ_CP029197.1|WP_078508707.1|4533630_4534566_+|TIGR03084-family-protein
MSDPVVVLDDLRDESDELDRLVAELSDERWGAPTPAAGWTIAHQIAHLAWTDRAAFLAATDAQAFAAETEKALAAPDRFVDEGAEEGAKLPPAELLADWRAGRERLQDALRAVPAGARFPWYGPPMSAPAMATARLMETWAHGQDVADALGIVRTPTARLRHVAWIGHRARDYAFLVRGLPVPAEPVRVEVTAPDGELWTYGPEGAAQRVTGPALDFCLLVTQRVHRADTALVAEGADADRWLDIAQAFAGPAGPGRTTKEASGPSRTAEDAPGPGRAAEEAAGPGRTDEEAPGRTATETPGSSRTAKEAP
>NZ_CP029197.1|WP_086024645.1|4532879_4533485_-|hypothetical-protein
MIMEEGARSGAEAARRLARTGRAEMLPGLSDAEFDRIEEEFGFAFSDDHRVFLAAGLPVGRPDPHGRPSPWPNWRGPDRDDLRWRLERPVDGVLFDVEHNSFWRREWGPRPAAPAEAVTAARAELATVPQMVPVYAHRYLPAGRGTHGHPVLSIQQTDVIYYGADLPDYVDREFNAAAAPRGWGEEDGEEAEATVPFWRDL
>NZ_CP029197.1|WP_015035386.1|4531431_4532820_-|M1-family-metallopeptidase
MTSLSGWRAPLLALAALLLLAPQTAVAQAPDGPSVAPSAATPDRPSYDVRLRADGDGSHWSGRQTVSFRNAARAPLTSVDLRLWGNGTDGCGAPDSPSPVRVGRVSGGTPRPLAVDCTALRIELPEPLPYGARASVSFDVDIAVPDRVHRFGKDGAYRYLGNALPLLSVRDEQGPHLDPDVGFGESFHTLAGDFRVVLDHPRALVVPATGTTTRRAGAPGRTVSTSVAHGVRDFAWAAGPFTSRTVTTPGGVRLNAYWTATTPPEGVETDLKAAVGSVDDFGRRFGHYPYGELDLVMSDNLDDFGSMEFPGLVLLWTEPEGSAVVHEIAHQWFYGIVGNDQFASPWLDESFAQYANQLYYGEPTATCWEDQGEWPSDTAALHRTMAYYADGHRSEYVRVVYIRGACALHDLERTLGSREMATMLRTYVRTHWLGVATTADFKHAAQSATDRDLGPFWREHRI
>NZ_CP029197.1|WP_015035385.1|4529550_4530768_+|hypothetical-protein
MTVVDTPASLATGYLYAAAARHAEGSERSGRLHPEVVTAMTAAGLARHFVPRRWGGRAGGFAELLDTVAEVGTACASTAWCGALLAAHGRLAAHLPVEGQRELWGDSPDTRVAAAVVPPAGRLRRVPGGWRLSGEWAFASGVEDAEWVLLASLDHSGAGAPGYRVLAVPRERVGIRETWDAVGLRATGSHSVVIEEAAEVFVPEHRTFLRETLVTGVVTGAVDPGEGAAGSEAGDAPAEVAPCHRVPYQLVASLQFAAPALGAARGALEAWTLMTGLRRLPDGRPLTEDPVVQQTLSRSAAEIDAAHLLLKAAATRADDWPGGAAGARDAREAVTALNQRDAAGAVDLLVGAVERLMRAGGARGLIAGGGLERAWRDVHAIAAHAALQPAPAAAAYAATVFPTSP
>NZ_CP029197.1|WP_015035382.1|4527735_4528509_+|HAD-IB-family-hydrolase
MSIAPGRAAFFDVDETLITCKSMACVLARFWGRGEVAARRFAAAHAELRRMIREGVPREQVNRTFFRFLAGSHLDDLETCGQEWYEKARTGGLLHTPVYEALRRHAGAGDLVVLVSGAFSACLEPLARDIGADLVVCTVPEVTSEGVLTGELVGPPMLGEAKGEAARRIMTAFGLGPEECFAYADDESDLPLLRSVGHPVLVGDGPVSAPPSETAGWSWLPGPAPAAAPSAPAPAPGRPSAARTAAATARRPVTQAA
>NZ_CP029197.1|WP_015035381.1|4527442_4527739_+|LysR-family-transcriptional-regulator
MELQHLRAFREVARELSFTRAAHNLHYSQPAVTAQIKGLEEDMGASLFQRRGNRSVELTPAGARLRPLAEQILELVDTAQHEIAGPVGAGGRARGGRA
>NZ_CP029197.1|WP_158506265.1|4526338_4527364_+|gamma-butyrolactone-biosynthesis-protein
MLQTVLPLEPLEPLESLESLVREAKDGLSFDRTISRRLVHRASVTEVFLTDAAVAGADRFLIGAQLPRNHALYRPEETGQCDFMLLVETVRQAGIYLSHRHYDVPLGHHFIFKALSLHISDPAALRVGAGPLAVVLDVNVATPGGRTAGIPGARNPRRFDARFDMVIEVGGRECARASAGVTVIDGVRYARLRQRGRTEGTVSARPSAYEGTAPARPSAYERKGGAPGDGRGVLRPAPGTAIRPAGTGEWRLHVDPTHPGYFEHPSDHVPGMLLLEAFRQAALELCGGTVLASLEAEFAVFGELGEAVTVQAAATTAGDGRMRLSATQGGRVLATAGARRA
>NZ_CP029197.1|WP_015035379.1|4525602_4526205_-|TetR/AcrR-family-transcriptional-regulator
MATPRSQPKQERARRTKVHILQSAAELFAERGYATVTLQDVAERAEMTKGAVYFHYTNKEALAVAVVQEHYARWPEILKGAEGDHAEPFDMLTAVLDTVTRAFARDIVVQAGARLQIERALIDAELPEPYVGWEDYLTRLIAEARDAGQLRDGVEPRAAARVLVSAFFGMQHISDVLSGRSDLTERYEELRTVLLEGLRR
>NZ_CP029197.1|WP_015035378.1|4524422_4525487_+|DMT-family-transporter
MNSQNTYTRGVLLCLLATVSWGAMFPLMDSTLQHIDPFTFTVMRYTIAGAMFLVFLRMREGREGLRLKGERIGLAWLFGTAGFAGFQFLVFFGQDLIGARGALNASIMMATMPMMGFLVNWVMKKVVPPKFSLVFIAMSFVGTILVVSNGDIGSLIASPKEAGADALLLFAALCWVVYTSGASYFPTWSPIKYTAITTVLGLASATVITAVILAAGGVPVPTAGAVGTILPQLAYMSVIAGFVGVLGWNFGNRYLGPLNGVLFMDVVPVTAFVISALTGVVPAGVQIVGASLTAAALVFNNLYLRRIAKAAPAASPAPAASGPSVGSSSGTSSGTASGSGSASAPAPVGSGTRS
>NZ_CP029197.1|WP_015035390.1|4536474_4538076_+|acetyl-CoA-carboxylase-carboxyltransferase-subunit
MTVLASALDTGGSDYADARAAMLDKLTALDAEHAKSLAGGGEKYVARHRARGKLLARERIELLVDPDTPFLELSPLAAWGSDYAVGASLITGIGVVEGVECLITANDPTVRGGASNPWTLKKALRANEIAFANRLPVISLVESGGADLPSQKEIFIPGGALFRDLTRLSAAGIPTVAVVFGNSTAGGAYVPGMSDHAVMIRERSKVFLGGPPLVKMATGEESDDESLGGAEMHARTSGLADHYAVDEPDALRQARRIVARLNHRKAHPDPVTAAEPPRYDEDELLGIVPGDLKTPFDPREVIARIVDGSDFDEFKPLYGPSLVTGWATLHGYPVGVLANAQGVLFGPESQKAAQFIQLANQRDIPLVFLHNTTGYMVGKEYEQGGIIKHGAMMINAVSNSKVPHLSVLMGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGPQQLAGVLSIVARASAVAKGQPYDEEADAGLRALVEAQIESESLPMFLSGRLYDDGVIDPRDTRTVLGLCLSAIHTAPVEGARGGFGVFRM
>NZ_CP029197.1|WP_051026128.1|4538114_4540064_+|ATP-grasp-domain-containing-protein
MTSITPSAASTTPSAAPTISTLLVANRGEIACRVFRTCRELGISTVAVYSDADADALHVREADAAVRLPGAAPSETYLRGDLVVKAALAAGADAVHPGYGFLSENADFARAVTAAGLVWIGPPPAAIEAMASKTRAKELLGIAPLTDVTEADLPVLVKAAAGGGGRGMRIVRELAHLEGELAAASAEAASAFGDGEVFVEPYVENGRHVEVQLLCDAHGTVWALGTRDCSLQRRHQKVVEEAPAPGLPAALEASLLDTAVRAAKAVGYVGAGTVEFLVAEGRAHFLEMNTRLQVEHPVTEEVFGVDLVALQLSVAEGRALPPEPPAPRGHAIEARLYAEDPARGWAPQTGVLHLFELPREGRVRLDTGYVSGDAVGVHYDAMLAKVIVHAPTRAEAVRKLAHALDRARIHGPVTNRDLLVASLRHPEFGDPGLLDTGFYDRNGATLTEPRTGAEYAAVAAALAEAAGRGGRFGGGWRNLRSQDETRTYGDHEVRYRPTRDGGYEVTAPEGVRVVSATPDRVRLEVGGVVRDFDVTAYEDGTVHAGRHRLTRRPRFTDPREQTAPGSLLAPMPGTVVRVADGLAVGARVEAGQPLLWLEAMKMEHRVIAPASGTLTALHAAPGRQVEVGALLAVVSDDATPDAAQEDQTV
>NZ_CP029197.1|WP_015035392.1|4540060_4541194_+|acyl-CoA-dehydrogenase
MSSMIESDELVALRAAVSALGHRHGPGFDRAALWAEAGKLGYLGVNLPEEYGGGGGGMAELSVVLEEAGAAGAPLLMMVVSPAICGTVIARFGTEEQKRAWLPGLADGSLTMAFGITEPDAGSNSHRITTTAERTEDGWVLNGRKVFVSGVDIADATLIVGRTSDARTGSLKPCLFIVPREVPGFQRRHIEMELDANEKQFELTLDDVHLPADALVGDEDAGLLQLFAGLNPERIMTAAFAIGMGRYALAQAVKYAKERQVWKAPIGAHQAIAHPLAQAHIELELARLMMAKAAQLYDAGDDMGAGEAANMAKYAAAEACVRAVDQAVHTLGGNGLTKEFGLARLVTAARVARIAPVSREMILNYVSHQTLGLPKSY
>NZ_CP029197.1|WP_078508901.1|4541731_4542217_+|hypothetical-protein
MPQLVGGTYADAAQLLKDNKGRAYGAYKDVVPPADAADWTVCFQRPDAGAPVGSTVPVVYLTEPGVPCPKSTSELLHKPTPKPTPTTQKPKPTPTPEPTRTRAPEPEPTEDAGDGSSGGGGSVSYRNCAAVRAAGAAPIHAGDPGYGRHLDRDGDGVGCEG
>NZ_CP029197.1|WP_041662747.1|4542268_4542664_-|RidA-family-protein
MQRTAVNPVTWSTGLGFDQGVVVSGQTRTLYISGQTAMDGDGRPRHDGDMAAQLALSTDNLEAVLAGAGMSLANLVRLGVYTTDVDLLFQHYGGLVARLAAAGVTPTMTMLGVTRLAVPGQLVELEGTAVA
>NZ_CP029197.1|WP_015035395.1|4542755_4543760_+|WYL-domain-containing-protein
MRADRLVSLVLLLRRHGRLTAGALARELEVSTRTVLRDIEALSAAGVPVYAERGRHGGFSLLPGFRTELTGLNHDEALALLAAGPGPAERVIGLGPSLASALRKVVDALPEGHRATASDAARRFLVDPETDLLSRRRTTEEVPGNVLAEVRRAVLTGHRLRIHYAAAGEPPRWRTVDPIGLVTVRDRGYLLATRAGEDRTYRLSRVRAAEELPEAADRPDRVDLDRVWRERTARFLSDGHLTVLVRVTPARREELLGTAVAARTEEPEEDGRLRLELTFQDARHAEWALWQLGPDAEALNPPSLRTALRARAAAIVAQYGDGDGGGSGDAGTLS
>NZ_CP029197.1|WP_041662748.1|4543869_4545462_+|AMP-binding-protein
MVFHSEYEAVPSVSLPIHDAVLGRAAERGELPALIDGAGELTLSYGQVDAFHRRVAAGLAEAGVRKGDVLALHSPNTVLFPIAFYAATRAGAAVTTVHPLATPEEFAKQLRDSAARWIVTVSPLLPAARAAAELAGGVQEIFVCDAAPEGEDVRSLQAFLGSTGPVPEIDVDPDEDIAALPYSSGTTGVPKGVMLTHTSIATNLAQLEPVIPMGPGDRILAILPFFHIYGLTALMNAPLRQGATVVVLPRFELDTFLGAIQKHRINGLYVAPPVVLALAKHPAVAEYDLSSLEYVVSAAAPLDAALAAACSARLGLPPVLQAYGMTELSPGTHVVPLDAPNPPPGTVGKLLPSTEMRILSLDDPSKDAAPGEEGEVAIRGPQVMKGYLGRPDATAAMIDTDGWVHTGDIGRVDDDGWLFVVDRVKELIKYKGFQVAPAELEALLLTHEGIADAAVIGVTDADGTEIPKAFVVRQPAAAGLTAEDVMAHVAARVAPYKKVRAVEFIDAVPRAASGKILRRELRDRELRDRA
>NZ_CP029197.1|WP_015035397.1|4545458_4546181_+|enoyl-CoA-hydratase-family-protein
MTLVAVTEERGITTLALNSPATRNALSAALVTELSDALTACGKDPAVRAVVLGHTGGTFSAGADLKAPPSPYAFVDLLRQVVELPKPVVGHVTGHVRAGGLGLLGACDIVLAGETADFALTEVRIGVAPAVISLTLLPKLEPRAAARHYLTGERFGVPEAVAMGLVTDGDQALPGILDALRAASPQGLREAKRLVTARVLETFERDAEDLVQRSATLFASPEAREGMTAFLERRDPAWRL
>NZ_CP029197.1|WP_015035398.1|4546168_4546768_+|TetR/AcrR-family-transcriptional-regulator
MAAVTAPKPDRNPKQDRSRATRQRLLEAAVSCLAEHGWVGSTVAVVAERAGVSRGAAQHHFPTREDLFTAAVEYVAEERSQALRTLPSRDRHEAVAALVDLFTGPLFRAALHLWVAASGEEQLRARVTELEARVGRESHRIAVEVLGADESRPGVRETVQGLLDMARGLGLATLLTDDRARRDRVVAQWARLIDEALDA
>NZ_CP029197.1|WP_015035401.1|4548080_4549148_+|isopenicillin-N-synthase-family-oxygenase
MTRSSYSPQSTLSSSPSQLPIVDLSAADRGPQARRLLHAQLHSAAHDVGFFQLVGHGVTEAETRALTSAMHAFFALPEADRLALDNINSPHFRGYTRIGDERTGGARDWRDQLDIGAERPARDPGPWEAPYWWLEGPNQWPAALPELRTAALHWIDRLSAVAERLLHELLASIGAPEDFYDDIFGPRAHPHLKLVRYPGSSGDGDDQGVGAHKDYGFLTLLLQDQVGGLQVQREDGNFHDVPPLPGAFVVNLGELLEVATNGYLIATNHRVVSPPGATERYSVPFFYNPRLDARISPLVFPYAQSAPGVTADPANPLFAEYGRNELKGKLRAHPLTTARHHADLLLHPETQPALS

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Crispr_ID: NZ_CP029197_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_18

5475982-5476100

Orphan

Consensus_repeat	Method
CAGCCCGCCCGGCGTTTGAGGGCACGGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_18

>merge|NZ_CP029197|18|5475982-5476100|CRISPRCasFinder
CAGCCCGCCCGGCGTTTGAGGGCACGGCCGCAGGCCGTACGGGGGCGGGCGCAAAGGCCCGCGCCTCAATCGTCGGCGGGGCTGGATTTCAGCCCGCCCGGCGTTTGAGGGCGCGGCCG

>NZ_CP029197|18|16|5475982-5476100|CRISPRCasFinder
CAGCCCGCCCGGCGTTTGAGGGCACGGCCG	CAGGCCGTACGGGGGCGGGCGCAAAGGCCCGCGCCTCAATCGTCGGCGGGGCTGGATTT
CAGCCCGCCCGGCGTTTGAGGGCGCGGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_051026160.1\|5470957_5471629_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
NZ_CP029197.1\|WP_015036280.1\|5486796_5488491_-\|maltose-alpha-D-glucosyltransferase	unknown	unknown	gnl\|CDD\|274140
NZ_CP029197.1\|WP_015036270.1\|5474353_5475760_+\|C4-dicarboxylate-transporter-DctA	unknown	unknown	gnl\|CDD\|234968
NZ_CP029197.1\|WP_015036276.1\|5479496_5481740_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP029197.1\|WP_106433886.1\|5468331_5468739_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015036268.1\|5471744_5472449_-\|response-regulator	unknown	unknown	gnl\|CDD\|226931
NZ_CP029197.1\|WP_015036272.1\|5477070_5477964_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187575
NZ_CP029197.1\|WP_051026163.1\|5481714_5482605_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367638
NZ_CP029197.1\|WP_015036274.1\|5478571_5479003_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133388
NZ_CP029197.1\|WP_041662879.1\|5478074_5478542_+\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP029197.1\|WP_015036278.1\|5482748_5485061_-\|1,4-alpha-glucan-branching-enzyme	unknown	unknown	gnl\|CDD\|235445
NZ_CP029197.1\|WP_015036261.1\|5462868_5464950_-\|phosphate-acetyltransferase	unknown	unknown	gnl\|CDD\|235537
NZ_CP029197.1\|WP_015036262.1\|5465306_5466332_+\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
NZ_CP029197.1\|WP_158506286.1\|5479020_5479338_+\|thioredoxin-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|200072
NZ_CP029197.1\|WP_015036279.1\|5485200_5486550_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237794
NZ_CP029197.1\|WP_015036271.1\|5476183_5477071_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381314
NZ_CP029197.1\|WP_015036265.1\|5468768_5469560_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015036266.1\|5470165_5470924_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|379135
NZ_CP029197.1\|WP_015036263.1\|5466714_5468067_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029197.1\|WP_015036260.1\|5461639_5462872_-\|acetate-kinase	unknown	unknown	gnl\|CDD\|234680

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_051026160.1\|5470957_5471629_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	0.000190412
NZ_CP029197.1\|WP_015036280.1\|5486796_5488491_-\|maltose-alpha-D-glucosyltransferase	gnl\|CDD\|274140	TIGR02456, Trehalose_synthase, trehalose synthase. Trehalose synthase interconverts maltose and alpha, alpha-trehalose by transglucosylation. This is one of at least three mechanisms for biosynthesis of trehalose, an important and widespread compatible solute. However, it is not driven by phosphate activation of sugars and its physiological role may tend toward trehalose degradation. This view is accentuated by numerous examples of fusion to a probable maltokinase domain. The sequence region described by this model is found both as the whole of a trehalose synthase and as the N-terminal region of a larger fusion protein that includes trehalose synthase activity. Several of these fused trehalose synthases have a domain homologous to proteins with maltokinase activity from Actinoplanes missouriensis and Streptomyces coelicolor (). [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP029197.1\|WP_015036270.1\|5474353_5475760_+\|C4-dicarboxylate-transporter-DctA	gnl\|CDD\|234968	PRK01663, PRK01663, C4-dicarboxylate transporter DctA; Reviewed.	2.37947e-164
NZ_CP029197.1\|WP_015036276.1\|5479496_5481740_+\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	4.21085e-105
NZ_CP029197.1\|WP_015036260.1\|5461639_5462872_-\|acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_CP029197.1\|WP_015036268.1\|5471744_5472449_-\|response-regulator	gnl\|CDD\|226931	COG4565, CitB, Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms].	2.11579e-64
NZ_CP029197.1\|WP_015036272.1\|5477070_5477964_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187575	cd05265, SDR_a1, atypical (a) SDRs, subgroup 1. Atypical SDRs in this subgroup are poorly defined and have been identified putatively as isoflavones reductase, sugar dehydratase, mRNA binding protein etc. Atypical SDRs are distinct from classical SDRs. Members of this subgroup retain the canonical active site triad (though not the upstream Asn found in most SDRs) but have an unusual putative glycine-rich NAD(P)-binding motif, GGXXXXG, in the usual location. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.1467e-73
NZ_CP029197.1\|WP_015036274.1\|5478571_5479003_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	1.74868e-38
NZ_CP029197.1\|WP_041662879.1\|5478074_5478542_+\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.798e-32
NZ_CP029197.1\|WP_015036278.1\|5482748_5485061_-\|1,4-alpha-glucan-branching-enzyme	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
NZ_CP029197.1\|WP_015036261.1\|5462868_5464950_-\|phosphate-acetyltransferase	gnl\|CDD\|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_CP029197.1\|WP_015036262.1\|5465306_5466332_+\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	4.44855e-173
NZ_CP029197.1\|WP_158506286.1\|5479020_5479338_+\|thioredoxin-fold-domain-containing-protein	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	4.07412e-33
NZ_CP029197.1\|WP_015036279.1\|5485200_5486550_-\|hypothetical-protein	gnl\|CDD\|237794	PRK14705, PRK14705, glycogen branching enzyme; Provisional.	1.15961e-79
NZ_CP029197.1\|WP_015036271.1\|5476183_5477071_-\|aldo/keto-reductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	1.67943e-96
NZ_CP029197.1\|WP_015036266.1\|5470165_5470924_-\|tyrosine-protein-phosphatase	gnl\|CDD\|379135	pfam13350, Y_phosphatase3, Tyrosine phosphatase family. This family is closely related to the pfam00102 and pfam00782 families.	3.34327e-75
NZ_CP029197.1\|WP_015036263.1\|5466714_5468067_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.22001e-07
NZ_CP029197.1\|WP_051026163.1\|5481714_5482605_-\|hypothetical-protein	gnl\|CDD\|367638	pfam03756, AfsA, A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.	1.47265e-18

>NZ_CP029197.1|WP_015036270.1|5474353_5475760_+|C4-dicarboxylate-transporter-DctA
MDSRGVHRDVDTHQHEEDPVAARRDRTHYLYLAVIGAVLLGIAVGFLAPGVAVELKPLGTGFVNLIKMMISPIIFCTIVLGVGSVRKAAKVGAVGGLALGYFLLMSTVALAIGLVVGNILEPGSGLHLTKELAEAGAKQAEGASESTPDFLLGIIPTTIVSAFTEGEVLQTLLVALLAGFALQAMGSAGEPVLRGIGHIQRLVFRILAMIMWAAPVGAFGAIAAVVGATGAAALKSLAVIMIGFYLTCAIFVFVVLGTILRLVAGINIWTLLKYLGREFLLILSTSSSESALPRLIAKMEHLGVSKPVVGITVPTGYSFNLDGTAIYLTMASLFVAEAMGDPLSVGEQISLLVFMIIASKGAAGVTGAGLATLAGGLQSHRPELVDGVGLIVGIDRFMSEARALTNFAGNAVATVLVGTWTKEIDKERVAEVLAGRVPFDETTLVDDHGAAVPEQRAEDGEEKARAGV
>NZ_CP029197.1|WP_015036268.1|5471744_5472449_-|response-regulator
MSSAPPPPLRVLVVEDDPVAADAHALYAGRVEGFTVVGVAHSRAAAVRLLDRTPVDLILLDLYLPDGHGLQLLRSLRAAGHSADVIAVTSARDLAIVREGVSLGVVQYVLKPFAFATLRDRLARYAEFRATAGEASGQEEVDRALATLRAPHPAALPKGLSAPTLESVTRTLRSTPAGLTAAEAGAAVGISRITARRYLEHLVTAGRAVRAPQYGQIGRPELQYRWLDGPARGH
>NZ_CP029197.1|WP_051026160.1|5470957_5471629_-|helix-turn-helix-transcriptional-regulator
MHQPSPPFNALAARRLREGLGMAPDHVAYGLRAQYGLFVTPDAVVAWERGRAVPDEQQLTALAGVLWCSPAELIAAPATLREHRMARGLAPEELALRVGVAAHAYQRMEDEGRWRGTERQTAALAEVLGLGPRALITATGGDERLAELLRDAATTRWQAYVKPAAKMLPLPRRTVEFALQRLHGEYHARMAATSSWGASGATGDEGRAYLDGITGHFWAAVGS
>NZ_CP029197.1|WP_015036266.1|5470165_5470924_-|tyrosine-protein-phosphatase
MRRHIPFERLHNFRDLGGYPTADGGTVRWETLYRSDSLAKLADAGPTDLERFRSLGVATVIDLRYPWEIAAKGRLPETEDVSWHNLSVEHRPYDQEAIDPALDPWRYLADRFAEVAEDGAVELRTALEVIAAADGPLVFHCASGKDRTGLLAALVLALLGVPDEEILADFALTELATERLIADWRAAHPGREPRWPGYGRAPADIMRLFLADLRARYGSVDAYVTGHVGLDPSVVTTLRSRLVDAPEAVSEK
>NZ_CP029197.1|WP_015036265.1|5468768_5469560_-|hypothetical-protein
MVQEEIEADPELRRQLQLQLTAPGTNATGSLLITGSQVSRSSIALGPLTINNTRSGRAVIALTAALLLALVVLVVYGGTRLITVDDSPGSSQDDSARHAARALNVSEVKQVVPDLTSMPSGWERSAPLRAGEDEDNGCSGAQASFNTNNWNDGTHTRKVWAEFTVRSCPSAALTAQGFEEIRSGVANNNKAREISLPELGDQRTAITHYNSGLDETTAVALLRVGTVLVELEYQPVPDDSGWSREFEQLASMAAARAQQVQNA
>NZ_CP029197.1|WP_106433886.1|5468331_5468739_+|hypothetical-protein
MAYVPQFRRDVLNAAAWLRSGEGSSLPFDGLSAEATHRRLWQRAGDDDESEADHQLSSRFRFLLWGPTTDNVVAHLFRERDHVVITLEFWRAEHLFTHPEDAGAVFVVEIPAEEFIGILEGIAAALDAPSSESRS
>NZ_CP029197.1|WP_015036263.1|5466714_5468067_+|hypothetical-protein
MTAGRHTPDPRGARTPAEFLARLQALKDWSGLTYRELSARAESGGDVLPRSTVANMLARTTLPREELLTAFVRACGATREEEARWRTVRNALAGRAGHGLGDTTGAAGPGEAGEPGEPGAWTEAADGAEAWGPAVERGPGGSAKGPADPGSPTGLVTPGDLADPADDHAGQRTPAGSGTPTGRTGPADPTGPTGPGTPADPTGPADPAGPGTPACPTDPTGLDPDRVEVAASAGGPPVWPTSEGGTGEPVTPPARIRRAVVAVVAVAGLVLAGVSVVALLREGHQGHPGHSGQPTRTGAPVAGGVRIRVAGTELCLAERRGTRTGQIHQVPCAEAGVPLYSLAEVGGGRWRIVSDHPDFGPGCSGIPSGGRIPDAPYEDSECGDPSRVEAFALEPYGTPVRGYRIVPAGSATPGSCVTVVGDRTAPWARLAQAPCAPDATGQLFSFERRP
>NZ_CP029197.1|WP_015036262.1|5465306_5466332_+|6-phosphofructokinase
MRIGVLTAGGDCPGLNAVIRSVVHRALTGHDDEVIGFEDGFKGLLDGHYRPLDLNAVSGILARGGTILGSARLERNRLAEAAESAPDLAREYGIDVLIPIGGEGTLTAARMLSDAGMPVVGVPKTIDNDISSTDRTFGFDTAVGVATEAMDRLKTTAESHQRVMVVEVMGRHAGWIALESGMAGGAHGICLPERPFQVDDLVKMVEERFARGKKFAVICVAEGAHPAEGSMEYQKGEIDQFGHERFQGIGNQLAVELERRLGKEARPVILGHVQRGGTPTAYDRVLATRFGWHAVEAAHRGEFGKMTALRGTGVEMVPLAEAVTQLKRVPEDRMREAESVF
>NZ_CP029197.1|WP_015036261.1|5462868_5464950_-|phosphate-acetyltransferase
MTRSVYVTGIDRGDGRQVVELGVMELLTRQVDRVGVFRPLVHDGPDRLFDLLRTRYRLTQDASTVYGMDYHEASALQAERGTDELVSQLVDRFHAVAREYEVVLVLGTDFAATQLPDELALNARLANEFGASVIPVVGGKGQPAESVRSETRNAFRAYDGLGCDVLAMIVNRVAAEDRAAIAERLAARLPVPCYVLPDEPALAAPTVAQIQHALGASVVLGDDAGLARDALDFVFGGAMLPNFLNALTPGCLVVTPGDRADLVVGALAAHSAGTPPIAGVLLTLNERPSDEILTLAARLAPGTPVISVPGNSFPTATELFSLEGKLNAATPRKAETALGLFERHVDTADLLKRVSVARSGRVTPMMFEHELIEQARADRRRVVLPEGTEERVLRAADVLLRRDVCDLTLLGDVETIRKKAADLGVTLAGTQLIDPQTSELRDSFAEKYAALRAHKGVTVELAYDVVSDVNYFGTLMVQEGLADGMVSGSVHSTAATIRPAFEIIKTKPEASIVSSVFFMCLADKVLVYGDCAVNPDPNAEQLADIAVQSAATAARFGVEPRIAMLSYSTGTSGSGADVDKVREATKLVREAHPELRIEGPIQYDAAVEPSVAATKLPDSEVAGQATVLIFPDLNTGNNTYKAVQRSAGAVAVGPVLQGLRKPVNDLSRGALVSDIVNTVAITAIQSQGQELPA
>NZ_CP029197.1|WP_015036260.1|5461639_5462872_-|acetate-kinase
MTTPTRVLVLNSGSSSVKYQLLDMRDDSRLAQGLVERIGEETSRLVHTPLQGGGAKREKNGPIADHAAALKSVAEELAADGLGLDSPELAAIGHRVVHGGLRFTEPTVIDDEVLAEIERLVPVAPLHNPANLTGIRTAMALRPDLPQVAVFDTAFHTTMPESAARYAIDVETADAYRIRRYGFHGTSHAYVSRETAKLLGKEPAEVNVIVLHLGNGASASAVRGGRCVDTSMGLTPLEGLVMGTRSGDIDPAVTFHLKRVAGMSADDIDVLLNKKSGLVGLCGDNDMREIRRRIDEGDERAALAFEIYVHRLKKYIGAYYAVLGRVDAVAFTAGVGENAAPVREAAIAGLEELGLAVDAELNSVRTDEARLISPDYARVAVAVVPTDEELEIARQTFALVGGETLGGVNA
>NZ_CP029197.1|WP_015036271.1|5476183_5477071_-|aldo/keto-reductase
MRQRALGDVRVGAIGLGAMPLSIEGHPDEARALATVHAALDAGVTLLDTADSYHPPGGEPGANELLVARALAAYGGRGRTEDVLVATKGGRGRTADGGWTVDGRPEHLRRAAEASARRLGVDAIGLYQLHKPDPAVPYAESLGAIRELLDAGTIRLAGISNVDTDRIRLAREILGERLVSVQNRYSPADRGSEPELRLCAELGLAFLPWSPLGGIARSSLDGASTLAADPEFGAFHRVARTHGVSPQRVALAWLLTRSATVLPIPGASRPESIRDSAEAGALRLTEMEIAELNGT
>NZ_CP029197.1|WP_015036272.1|5477070_5477964_-|NAD-dependent-epimerase/dehydratase-family-protein
MDILIIGGNRYFGKRLTLRLLESGHDVTMLNRGSSGVPEGVTHLIADRNDENALESALGDRTFDVVIDQVCYTPVQAAIARRVLGPRTRRYVMTSTVEIYEFQHSATPLREDAVDPRTVTVDPGLPWADPEFLETHYGEGKRQAEAVFAAAPAFPYTAVRVAHVLGGADDFTGRIGHYADRIRAGEPIAVPAENHPATYVYVEEIAAFLAWAAENSFTGPVNAHSHGALTTADICAEIERLAGGRTVFQKVEVGEVSPFSFARSYAMDNSRATELGFTFRDSTAWLPQALSETLGTN
>NZ_CP029197.1|WP_041662879.1|5478074_5478542_+|Lrp/AsnC-family-transcriptional-regulator
MGAFDPIDRQILDLLQTDGRIKLSELGRRVRLSPAAVTERVRRLEACGAVTGYGAHVSAARLGYGIRAFIRVNPHGGYTLKHPRTLELTARPEVLEVHHVVGEDCWILKVAVTDTVHLEEVLEQTSALGRTTTSIVLSSPVERKPLLPPGGTPLP
>NZ_CP029197.1|WP_015036274.1|5478571_5479003_+|MerR-family-transcriptional-regulator
MRIGELAERAGTTTRTLRYYESRGLLTARRTEQGHRTYDEADLRLLQQIRTLQDFGFELEETRPFVDCLRAGHPAGDSCPASIAVYRRKVAELDGLIEQLRAVRAQVGAQLLRAEAELPHGPEPRCELDAQWETETETERGRE
>NZ_CP029197.1|WP_158506286.1|5479020_5479338_+|thioredoxin-fold-domain-containing-protein
MAEVTDGDFEAEVLGSGLPVLVKFTAEWCGPCRQLKPVLGAIAAEEAERLRVVEIDVDRNPETTLRYGVLATPTMLVFRAGEPVKSLVGARPKRRLLEELADVLG
>NZ_CP029197.1|WP_015036276.1|5479496_5481740_+|AAA-family-ATPase
MSTEEFRNEQQFITDLYARLDDLRTEAEAAVERALRTPGVGSNQGRLERDVLVAEQSGLLSALNAGESGLCFGRLVFKDGRDHHIGRLGIREDDPNRTPLVVDWRAEIARPFYLATGYEPMGLSRRRHISTLGRTVTALHDEVLDLADATRTGHESRDADEVLLAALDAARTGRMHDIVQTIQAEQDAIIRSPHRGVLVVEGGPGTGKTAVALHRAAYLLYAHREQLAKRAVLIVGPNPAFLGYIGNVLPSLGETGVLLATPAELFPGVRATGTDTARAAAVKGSAAMADALAAAVRDRQQVPERGEPLIVPHEDGDLVIDWDMALEARHKARETALPHNLARPYFVFRILDALAEQLADRIGADPYGGPNFLGPDDIALLAKGIAGNPEVYAAIDTLWPALTPQDFLADYLAEPTHLTDEDARAIRRDGGAWTPADVPLLDEAAELLGEDDSAARAAEEAERQKQIQYAQGVLDVSYASRTYEFEDKEEQDKDASEVLSAHDIIDAERFAERHEEADHRTAAERAAADRTWAFGHIIVDEAQELSAMAWRLLMRRSPSRSMTLVGDPAQTGDPAGVGAWERILAPYVEDRWELVRLGVNYRTPAEIMAVAAEVRRADDPGFEPPSSVRSTGVEPWDRTVDDPVKEAADAVATERREEGRIAVIAPQELHPGLVAALPDAAYGPAPDLTRPVVLLDPRQAKGLEFDTVLVVDPEGIVAGAAHGTNDLYVALTRATQRLGIIRSAARR
>NZ_CP029197.1|WP_051026163.1|5481714_5482605_-|hypothetical-protein
MRDTVERRLSPELCHRVRSEDTFPVEWRPLDGKDRFAVRAAWPADHPFFTPVRRGAERCHDPLLLVETLRQSTMALLHDAHGLPLSRHILLGEISLACDPAGLTVTGEGADIEVRFAELLRRGDQLSDTRVDWIVRRGARAVATGGARARFVGPAAYRRLRGGHVEAGAVRPGPRVRRAPAPLTGRARTEDVLLAPGGREGVWKLVVDTGHPQLFQRPNDHIPGMLFLEAARQAASAAAWPRPCLPSALRIVFDRYAEFDGGPCLLRVESGRAAGEFEVTGYQDGARLFTCGLRSG
>NZ_CP029197.1|WP_015036278.1|5482748_5485061_-|1,4-alpha-glucan-branching-enzyme
MTARPVGKTARSSKAPKAAQAEKATTKPRAPKAPKAPRTAPPIDPGDRARLLAGEHHDPHGVLGAHPVRGGVAVRVLRPWAKEVTVVTKGKRVPLRHEGDGIFSGLLPLLRKVPAYELRVRYGDDASDELALHDPYRFLPSLGDLDLHLIGEGRHEELWTALGSHVMTHDGVTGTRFAVWAPNARGVRVTGDFTHWDGTGLPMRSLGSTGVWELFVPGIGEGALYKYDITRPDGTHTVRADPMARRTECPPNTASIVTASHYTWDDAEWMRRRGDRPPHEAPISVYEVHLPSWRPGLTYRQLAEQLPAYVRDLGFTHVELMPVTEHPFGGSWGYQVTGFYAPTARMGTPDDFRFLVDALHRAGIGVLMDWVPAHFPKDDWALAEFDGRPLYEHEDPRRSHHPDWGTLEFDYGRKEVRNFLVANAVYWCQEFHIDGLRVDAVASMLYLDYSREHGEWLPNEFGGRENLDAVRFLQEMNATVYRRCPGVVTFAEESTAWDGVTRPTDQVGAGGFGGLGFGMKWNMGWMHDSLEYMQKEPVHRKYHHHEMTFSMVYAYSENYILPISHDEVVHGKRSLVSKMPGDWWQQRANHRAYLGFMWAHPGKQLLYMGQEFAQGAEWSADHGPDWWLLDPAYGAEPDHRGVRDLVRDLNTVYAATPSLWERDTAPEGFQWVVGDAAEDNVFAFLRFDAFGSPLLAVSNFSPVVRHDYRLGVPDQVVAWAEVLNTDAGRYGGGDVVGRDPLKTESVPHHGRSASIRMTLPPLATVWLRPA
>NZ_CP029197.1|WP_015036279.1|5485200_5486550_-|hypothetical-protein
MPETASTTRAPDALLPSLAPLLHEWLPRQRWFAGKGRRVTGFTLDAATELLPLDGAGPGLLHLLVRVEQPSRPAGTPADCYQLVLGVRPQLPPRLAPALIGRIRQGPLAGRAVYEGLRDPRLAGLLYERLRTPGRTGPLRFHATTSLPPALAPRMLDAEQSNSSLVYGDSFILKIFRRVSPGANPDLELPLALAGAGCARVPAPVAWFESGASTLGVLQPYLRDSRDGWRLALDALADGREFTAEARALGRATAEVHLALASALPTRRLGRVETERLAAAMDHRLHAAAQAVPALLPYVPGLRAVFAAASGTTGDGVVQRIHGDLHLGQTLRGSDGGWAVIDFEGEPAKPLDERRSPQPTVRDVAGMLRSFDYAARTHRPWNADWAARCRAAFCTGYAEAAGTDPRADPALLRAYETDKAVYEVVYEARHRPDWLPVPMSAIQRLSTSP
>NZ_CP029197.1|WP_015036280.1|5486796_5488491_-|maltose-alpha-D-glucosyltransferase
MTVNEPVPDTFEDTPAKDLDPDWFKRAVFYEVLVRSFQDSNGDGVGDLKGITSKLDYLQWLGVDCLWLPPFFKSPLRDGGYDVADYTSVLPEFGDLADFVEFVDAAHQRGMRVVIDFVMNHTSDQHEWFQESRRDPEGPYGDYYVWADDDKQYADARIIFVDTESSNWTFDPVRKQYYWHRFFSHQPDLNYENPAVQEEILSALKFWLDLGIDGFRLDAVPYLYQQEGTNCENLPATHAFLKRVRKEIDDHYPDTVLLAEANQWPEDVVDYFGDFRSGGDECHMAFHFPVMPRIFMAVRRESRYPVSEILAKTPEIPSGCQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMRANIGIRRRLAPLLDNDRKQMELFTALLFSLPGSPVLYYGDEIGMGDNIWLGDRDGVRTPMQWTPDRNAGFSSCDPGRLYLPAIMDPVHGYQVTNVEAGMASPSSLLHWTKRMIEIRKQNRAFGTGTYTELPASNPAVLAFLREDGDDLVLCVNNFSRFAQPTELDLRRFDGTQPVELIGGVTFPAIGQLPYLLTLAGHGFYWFRLKKG

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Crispr_ID: NZ_CP029197_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_19

5588405-5588520

Orphan

Consensus_repeat	Method
GCGTTGTAGAAGTCGCGCATGCTGCCGATGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_19

>merge|NZ_CP029197|19|5588405-5588520|CRISPRCasFinder
GCGTTGTAGAAGTCGCGCATGCTGCCGATGTGGAATTCACCGTTCCCGCTCATGGCCCATCCTCCCCACGCTGCCCGGGCCGGACGCGTTGTAGAAGTCCCGCATGCTGCCGATGT

>NZ_CP029197|19|17|5588405-5588520|CRISPRCasFinder
GCGTTGTAGAAGTCGCGCATGCTGCCGATGT	GGAATTCACCGTTCCCGCTCATGGCCCATCCTCCCCACGCTGCCCGGGCCGGAC
GCGTTGTAGAAGTCCCGCATGCTGCCGATGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_041662892.1\|5581801_5582035_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015036353.1\|5582051_5583563_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
NZ_CP029197.1\|WP_015036366.1\|5596217_5596415_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015036350.1\|5579997_5580294_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
NZ_CP029197.1\|WP_015036354.1\|5583654_5585304_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378342
NZ_CP029197.1\|WP_150253472.1\|5585639_5586467_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP029197.1\|WP_041662895.1\|5587111_5588116_+\|quinone-oxidoreductase	unknown	unknown	gnl\|CDD\|176189
NZ_CP029197.1\|WP_015036351.1\|5580299_5581796_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
NZ_CP029197.1\|WP_015036363.1\|5592602_5594897_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP029197.1\|WP_015036368.1\|5599526_5600669_-\|glucose-sorbosone-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP029197.1\|WP_041662896.1\|5595480_5596068_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015036364.1\|5594874_5595432_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP029197.1\|WP_015036369.1\|5600770_5601793_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381302
NZ_CP029197.1\|WP_015036349.1\|5577776_5579891_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	unknown	unknown	gnl\|CDD\|238923
NZ_CP029197.1\|WP_015036367.1\|5596422_5599473_+\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|226415
NZ_CP029197.1\|WP_015036361.1\|5589145_5590075_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041662894.1\|5586580_5587006_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP029197.1\|WP_015036362.1\|5590302_5592414_+\|phospholipase-C,-phosphocholine-specific	unknown	unknown	gnl\|CDD\|274561
NZ_CP029197.1\|WP_015036355.1\|5585400_5585643_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP029197.1\|WP_041662897.1\|5601895_5602834_+\|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240643

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015036369.1\|5600770_5601793_-\|aldo/keto-reductase	gnl\|CDD\|381302	cd19076, AKR_AKR13A_13D, AKR13A and AKR13D families of aldo-keto reductase (AKR). Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.	4.86845e-127
NZ_CP029197.1\|WP_015036353.1\|5582051_5583563_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
NZ_CP029197.1\|WP_015036350.1\|5579997_5580294_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	2.20028e-37
NZ_CP029197.1\|WP_015036354.1\|5583654_5585304_-\|hypothetical-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	2.85419e-22
NZ_CP029197.1\|WP_150253472.1\|5585639_5586467_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.11769e-05
NZ_CP029197.1\|WP_041662895.1\|5587111_5588116_+\|quinone-oxidoreductase	gnl\|CDD\|176189	cd05286, QOR2, Quinone oxidoreductase (QOR). Quinone oxidoreductase (QOR) and 2-haloacrylate reductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. 2-haloacrylate reductase, a member of this subgroup, catalyzes the NADPH-dependent reduction of a carbon-carbon double bond in organohalogen compounds. Although similar to QOR, Burkholderia 2-haloacrylate reductase does not act on the quinones 1,4-benzoquinone and 1,4-naphthoquinone. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.56785e-168
NZ_CP029197.1\|WP_015036351.1\|5580299_5581796_+\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
NZ_CP029197.1\|WP_015036363.1\|5592602_5594897_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	7.27427e-94
NZ_CP029197.1\|WP_015036367.1\|5596422_5599473_+\|LuxR-family-transcriptional-regulator	gnl\|CDD\|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	3.11933e-39
NZ_CP029197.1\|WP_015036364.1\|5594874_5595432_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	4.8143e-25
NZ_CP029197.1\|WP_015036349.1\|5577776_5579891_+\|bifunctional-diguanylate-cyclase/phosphodiesterase	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	1.97567e-103
NZ_CP029197.1\|WP_015036368.1\|5599526_5600669_-\|glucose-sorbosone-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	4.18659e-79
NZ_CP029197.1\|WP_041662894.1\|5586580_5587006_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	7.65475e-20
NZ_CP029197.1\|WP_015036362.1\|5590302_5592414_+\|phospholipase-C,-phosphocholine-specific	gnl\|CDD\|274561	TIGR03396, PC_PLC, phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis].	0
NZ_CP029197.1\|WP_015036355.1\|5585400_5585643_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	4.60683e-18
NZ_CP029197.1\|WP_041662897.1\|5601895_5602834_+\|2-hydroxyacid-dehydrogenase	gnl\|CDD\|240643	cd12166, 2-Hacid_dh_7, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	3.15882e-145

>NZ_CP029197.1|WP_041662895.1|5587111_5588116_+|quinone-oxidoreductase
MQVYEVGGPEVLRETEVDQPRPGPGEAVVEVAASGVNFLDVYHREGRYTLPLPFTPGAEGAGTVVEVGPGVTDVAVGDRVGWVEIPGTYAERAVVDASRLVPLPDDIDFETAAAVLLQGMTAHYLIKDAYPVQAGDTVLVHAAAGGMGLLLTQLITHLGGRVIGTTSTAAKAELAKRAGAAEVILSSAVDDLAAEVRRLGGGQGLPVVFDGVGAHTFDASLASLRTRGHLVLFGAASGAVPPFDPIRLAHGGSLTLIRPSLGDFIADRSELLRRAADVFAWVRSKALEVTVTGRYALSEAAQAHSDLEARRTTGKLLVIPGAAADLPGLPGRSG
>NZ_CP029197.1|WP_041662894.1|5586580_5587006_+|ATP-binding-protein
MSDELPLFREAFYRRERRSVPLARDFARKALADWGLDARADDVLVCVSELATNALRHGVPPGRGYRLHLYLERPGPLRVEVHDSGDGTPAVREPSGESGRGLLLVGALADRWGVGARHPGKIVWCEFAPAEGGPEAFPDSP
>NZ_CP029197.1|WP_150253472.1|5585639_5586467_-|helix-turn-helix-domain-containing-protein
MQRGTNSRKKVPSWEVVGALLALYRKQAGLTQPQLATQACVALETLGSIEQGRRALRLGLAGELDGILNTGGALAVAVGKAPKKERFPAFAQEFIELEAQALSLMGYENGVVPGLLQTAEYARAVFDCLYPPITPQEAEDRMLDRLDRQRVFEQKPWPPMMSFLLNESILEQPIGGREVLRGQVLHLREMAELPFLALQIIPKSRTTHAGLNGPMVLIETPAHEHVAYIEGQRVSFLIDDPDEVGILQAKYGMLRSQALTPEDTMGLLERLAGVT
>NZ_CP029197.1|WP_015036355.1|5585400_5585643_-|DUF397-domain-containing-protein
MSAAALSWFKSSYSGDEGGACLEVAYDWRKSSYSGSEGGACVEVAAHPAAVHVRDSKLGETSPVFTVSPTAWDAFVGAAN
>NZ_CP029197.1|WP_015036354.1|5583654_5585304_-|hypothetical-protein
MLLVASSLQLTTPATAEPTPDHPPLGAVFPLGDHSAPKTGSKELAPGVTYRVFTQGAANDVWTVWVRYDDGQEVTTGKTTATALAERLRTAGYGDARVVPLDSPATADTYAQTFYGVHVGSYATATEAKALQEELKTKGFADSRTLYTAETNADSRGPWQIRVITVRPDAQVDLRTEHGTNVSGSETVRQLSAAAGALAAVNGTEFDIDSINNTAFTGHEGVPQGLYMKNNVLLGSPNNGRTALLLNAAGGGHRITEVKSRTWITAPDKTERDVDGVNRVAGQILGCGGVGDDFRKTASLGNVPRLDPWRNGICYDPNEIVVFRPEWGTTTPAPAKEWAGTPVTEVVMNGNWDVLSLRDAPGPIPAGGRVLQGIGKGREWLRTLKPGDRVTPHTTVTDTAGTPVTAPTLSAVGAGTPALMRDGQVWLNPAANGMAHVACALPAPAGGCRPSGALTARHPRTLAGISPEGHLMLVTIDGRNPGAGVGVTLPEAARVMEWLGARDAVGLGSGGDTTLMVENTLYNRPRDQWSDTASHERAVSNAVVVVPRS
>NZ_CP029197.1|WP_015036353.1|5582051_5583563_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MTVTELLSYEAALAEYDPVMGLEVHVELGTKTKMFCGCSTELGAEPNSQTCPTCLGLPGSLPVVNAIGVESAIKIGLALHCEIAEWCRFARKNYFYPDMPKNFQTSQYDEPIAFNGYLDVQLEDGEVFRVEIERAHMEEDTGKSLHVGGATGRIHGASHSLLDYNRAGIPLIEIVTKPIEGAGERAPEVAKAYVAELRELIRALGVSEARMDKGQMRCDVNLSLRPHGTKTFGTRSETKNVNSLRSVERAARFEIQRHAAVLSSGGSIVQETRHFHEDDGSTTSGRIKDNAEDYRYFPEPDLVPVAPAREWVEELRGGLPELPRVRRNRLREEWAVSEQEMQSILNAGAVDAIVATTEAGADAASARKWWMGELARNANEKGVSLEELPISPADVARVSALVAGGDLNDKLARQVIEGVLAGEGTPDEVVEKRGLKVVSDDGALGTAVEEAIAGNAAIADKIRGGKVAAVGALVGAVMKATRGQADAAKVKDLILEKLGVSEG
>NZ_CP029197.1|WP_041662892.1|5581801_5582035_+|hypothetical-protein
MAKKAKNFKKSKTGVYVSLATTAFGAISVAKQAKLARNDHDMLRLIDSAVSAAAIVTGLAILYRELKRLGDDDVLLG
>NZ_CP029197.1|WP_015036351.1|5580299_5581796_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MTDNIIKLTAAEIAGKIAAGELTAVEVTEAHLARIEAVDEKVHAFLHVDREGALAQARAVDEKRARGEKLGPLAGVPLALKDIFTTAGMPTTVGSKILEGWIPPYDATLVKNLKAADVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTRIPGGSGGGSSAALAAYEAPLAIGTDTGGSIRQPAAVTGTVGVKPTYGGVSRYGMVAFSSSLDQGGPCARTVLDAALLHEAIAGHDPLDSTSIDAPVPPVVEAARNGSVAGMRVGVVKQFRGEGYQAGVVQRFDESVELLKSLGAEIVELDCPTFDLALSAYYLIAPSECSSNLARFDAMRYGLRVGDDGTRSAEDVTALTREAGFGDEVKRRIILGTYALSSGYYDAYYGSAQKVRTLITREFEKAFEDVDVIVSPTTPTTAFPIGERADDPMAMYLADLCTIPTNLAGNAAMSLPCGLAPEDGLPVGLQIIAPAMKDDRLYKVGAAVEAAFVEKWGHPLLEEAPSL
>NZ_CP029197.1|WP_015036350.1|5579997_5580294_+|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MPGITREEVAHLARLARLELKGEELDHFAGQLDDIIGAVARVSEVADQDVPPTSHPLPLTNVMRADEVRPSLTPEQALSGAPAQEQQRFKVPQILGED
>NZ_CP029197.1|WP_015036349.1|5577776_5579891_+|bifunctional-diguanylate-cyclase/phosphodiesterase
MEPTESAAPVPRPHGRVAPEGFTSRLPAAVVGIAAVVLVAGLQQALTAGHGLFPDGVTGWSLAVLTGLIVGHLVALGRDRWWGGTGSGAALTLAVLLLYGWVPAGLVSMTVVALVGAARRHRWRQGVLHGAADVLGVAVAALVLALFGDVPTVEQPWQPLDWTIGDLPEVVLAAATYLVVTRLLLWYTLAPQGRGLPTVARTALLRQGLVAVALLGIAPLICVVAASSPVLLPLFAVPLIALDSTLWIARARAEEQLRDPLTGLPNRQWLLERAWTALEEAEGEGARAALVLIDLDRFRSVNDTLGHLAGDRLLLQIAERLRLALPRGAEAARLGGDEFAVLLPTADSTTSAQRVARHLVAELSSPLDLDGLTLVLEASAGVAVFPDHALDAEGLLRRADVAMYQAKRDRTGVEVYESKRDSNTPDRLGLLGDLRRALDAGEVELHYQPKVQFDGQVAGLEALVRWVHPERGKVPPDEFIAIAESSGLMPHLTEYVLETALAQVARWRAQGLNVPVAVNVSPRDVHTPGFAGAVAARLARHGVPAGALQLEITEHVLLEDPQRAADTLNGLTGHGVKMSLDDFGTGYSSLVHLRRLPVSELKIDRSFVARLAVDTEDAEIVRCTVDLAHSLGLLVVAEGVEDDETWERLRDLGCDAVQGWLVAAAMPPGEATAWLLARGEHGWRRPADIAAELAVDHPSGQVVQ
>NZ_CP029197.1|WP_015036361.1|5589145_5590075_+|hypothetical-protein
MSIEPADYVARLRAQANDPGREEALRRDRTVRRRRIALAAGAGVLLLGGFGFWLADVTGERPPYEPYAPEMLYEASWPREWPYSENMPFRDSPAFDWEAGADGIYVPQPMPSGEFTREEITAVLDDVKTLLVGTNLSEETLFGGSEPAAALALLDPRGAGAAVRKDLVTRFDPDEVYLHETGIRTRGTLTHELSAAGELVVRADYSFVYPLVSASAGREVLPGVPEVARISVRRQLTVTSRGGKLVLGAYASEVGNHDCSAPRDGYLHPLFAEGRWKAARAAEGPLVDPYGEKRVLPSGPGHCVTPTGT
>NZ_CP029197.1|WP_015036362.1|5590302_5592414_+|phospholipase-C,-phosphocholine-specific
MSSEKSPELSRRRLLALGGGAVGVATAGSLLPPSLQAAMAAEPPAGGMSAVRHVVILMQENRSFDHYFGTLRGVRGFSDRNAIELPSGKPVFEQPAALGRTVLPFPIRGAAETQRKDLQYIGDLDHSWGGGGKAWHGGWMDGWVSAKTAATMAYYDRQDIPLHHELADTFTICDAYHSSIHTSTSPNRNHLWSGWTGYEADGSRAVTNAAYAEDTHPGYGWPTYAERLEAAGRSWKTYTEWENFTDNNIEFFTRFKKIARKALAKTGGHTFMESFYAAVRDTEDLTERTRLLGLLEEGVATLTDAERSLFERGLRRVESGTLADAFRADVAARTLPEVSYLVPSAIDSEHPGSSSPVASASLVYKVLDALGAHPDVWRHTVVLINYDENDGFFDHVPPPVPPADDPSGDAERWQGRPTGLGIRVPLLVVSPWSVGGYVCSETFDHTSVIRFLERLTGVREPNITPWRRTVTGDLTSAFDFRRTRRLPPVEQPGAIPPFTGRWRPQPPAVQRMPVQEPGVRPARPLPYQPDASATVAPGAVRVALSNRGKASAHFALYPYAGEFDLPQHRDVRGTGEWTVPVPGDHYRFTITGPNGFRREFEGPAAGGAELVSRIDHHDRDLHLTVRNTGPSAVFFTVRPLGYVDEDDLDDWTRTVKVKPGKTRTLVHSAADAHGWYDIEVTAPGGFRRRLMGHIENGRASVSG
>NZ_CP029197.1|WP_015036363.1|5592602_5594897_+|MMPL-family-transporter
MAAIARWCIRHRLVAVLLWLVALCGVGTAAALAGNAYSNDYEVPGTESGRATALLERGFHGLGGDSDTIVWHTDRGSVRADAVEKRMTAVLDQVADLPGIAAVTSPYGDTRGQVSEDGHTAYATVTFHEQADDIPEAQARALVDTAKAAEGDGLAVELGGSAVALTEAPGGHIAEIVGVAVAAVVLFLAFGSLAASALPIATALVSVGIAYSGIALLGHLMTVADFAPMLGLLVGLGVGIDYALFIVTRHRRGLKRGLSVAEAAETAVATTGRAVVFAGATVCIALLGMLILRLSFLNGVAIAASLTVVLTVAASVTFLPALLSFIGVRALSRRERRALAEHGPQPELPTGFAARWSAFVERHPKLLGLAAVVVMGVLALPTLSLHLGTSDQGNGAATATTRKAYDLIADGFGPGVNGPLTLVAGLDGADDRVALDQLPAALSATKGVASVSPVTYNGSGDTAFLTVVPESSPQSKATSELVDRIRTDVLPEAGTGTSLQVHVGGVTASYDDFAEIIVGKLPLFVGVVIALGCLLLLLAFRSIGIPLKAAAMNVAAVAAAFGVVVAIFQWGWGSELLGLGSAGPIEPFLPVIMVSVLFGLSMDYQVFLVSRMYEEWLETGDNRRAVRVGLAETSRVINSAAVIMISVFLAFVLSGDRVIAMFGIALAAAVALDAFVLRTLLVPALMHLLGGANWWLPKWLDRLLPRLSIEPPECREAADFREAGVSPEAVVTRGKIPVQRVTAEAAAPAAAAEERNDDVRDTAG
>NZ_CP029197.1|WP_015036364.1|5594874_5595432_+|GNAT-family-N-acetyltransferase
MFAIPLGDDGAELRPLEPSNAEEFLAHMDRGRAFVGEHIVLADVVTDLDSARSFLRSYAEKAASDTGRIYGIWVDGTLVGGVLFRTFDAAHGIAEAGCWLEPSAAGKGLITRACRVIIDWAIEERGIHRVEWYASAKNEPSIAVARRLGMTREGVLREHYPHRGVRADTELWAVLAPEWRAAKTV
>NZ_CP029197.1|WP_041662896.1|5595480_5596068_+|hypothetical-protein
MDTKTTTEKTDEGTDASGTAEETAAVALDKKDTEPATAPIEADANADGDEAGDADRDDEDEEPAGEAAPAPAGIGGAAAAVVSAALGAVALTGTWTGKVVSERETLLGQIKTSGTGTPAQQISEIYGDAWHSTALVNGVFALIALLVAVLVLVLPGRPAWVRAVAVAGAVLGGLGLLLSVGTYFDLFLSLPTAGS
>NZ_CP029197.1|WP_015036366.1|5596217_5596415_+|hypothetical-protein
MFEYELHRMNHAQLVREAAAERLAHQAAETAGATRGLRRLGRRGGGQDPEGRVNDGGRGRFVRAA
>NZ_CP029197.1|WP_015036367.1|5596422_5599473_+|LuxR-family-transcriptional-regulator
MSAHADLCAMLGAVETRSVSPVFVGRAGELTALTEALSRATAGEPQALLIGGEAGVGKTRLIEEFLDAACERGAVVALGGCVELGADGLPFAPFATALRSLHRRLPGELLAAAHGHEAELARLLPELGDPGGQDSSDEDSTARLFELTVRLLERLAADRTIVLVLEDLHWADASTRHLLTYLLRTLRRGRIAVVASYRADDIHRRHPLRPLLAELDRLRTIRRIELARFSRTEVHRQLTGILAAEPDPGLVDEVFERSDGNAFFVEELVVSHEAGCAAGQLSDSLRDLLLVRVETLPEDAQRVARIVAEGGSTVEYGLLAAVARLSEDDLIEALRAAVGANILLAAPDGDGYRFRHSLVREAVSDDLLPGERSRLNRRYAEALEADPTLVRADERANRLATYWYHAHDPAKALPAVLGASVATRKRHAYAEQLSLLERAMELWDKAPAETRDSLRPIDYADAYPACGCDPDTTSLRFLDLLAEAAVAARLSGERERAAKICRTALRILDDENDPLRAAWFWTETARLQSNLGRGDGWPEIARAQELVKGLPPSAVHATVLVGAAGWGMLRNPGPEALAAAERAVEYARFVKNEPIELNARITLGTIMVSAGDTEGGLAALHQARERTIALGQFHEATRAHINISSSLEALGRSREAVEIATTGIDLARSRGLVDSAGWIRANLSESLLSLGEWDRSKEEAEELLRSGASSTKPGGTALLQLAHLAAARGEPARAAEHLAEARTRYGTRDPIPQYTLPMAQVEIAIAAAEGRLADVRHQLAAMADAGFPPGTHRYGWPLVLTAVTAEADSRGLPAADEGRAEALDVVRRCVRGLAVQAPVWEAYSLQVSEELARAEGRDTAARWAEVVAAYEPVERPYQLARARHRLADALLVEGGRREEATALLREAHATAVRLGARPLREDVELLAARARLSLAAEKPPAAAEPGDDTFGLTPREQAVLGLVAAGRTNRQIAEELFISPKTASVHVSNILAKLGVSGRGEAAALAHRLHLLDPAL
>NZ_CP029197.1|WP_015036368.1|5599526_5600669_-|glucose-sorbosone-dehydrogenase
MSRPAVVKALWGAAVLVLVAGCSSGGTEDRPGTAPPTSPPVTVSASAGPSGSASAPTGGRVAVAGTLTEGLRSPWGLAELPGGDLLVSSRDERTITRVDGRTGAKTPLGEVPGVVPGGEGGLMGLAVRDGWVYAYLTAESDNRIVRMRYGGGDGDRLGAPQPVLTGIPKGLVHNGGRIAFGPDRMLYAGTGETGRTGLAQDRESLGGKVLRMTPEGRPAPGNPFAGSVVYSYGHRNVQGIAWDDEGRLWAAEFGQNTWDELNLVEPGKNYGWPEAEGRAGESRFVDPVAQWPTSEASPSGIAYARGAIWMAGLRGQRLWRVPLSGAERSGDPEAFLSEEYGRLRTVLAGGGGRLWLVTSETDGRGTPGPGDDRILRLEVS
>NZ_CP029197.1|WP_015036369.1|5600770_5601793_-|aldo/keto-reductase
MERRTIGATALDVGAIGLGCMPMSWAYSRSEQRGDRSLRTVHAALDAGVSLLDTADMYGPFTNELLVGRVLKERRADVFVSTKCGLLVGDGGERRHVVANGRPGYVRRACDASLRRLQTDVIDLYQLHRADPEVPVEETWGAMAELVSAGKVRALGLCAVGARSARRGATGVGRDGYEGTIRQLERIQQVFPVAAVQAELSVWSQEALVRLLPWCVARGVGFLAAMPLGNGFLTGTLTPGGGFEPDDPRARHPRFTAEMMAANQPLVAGLRRVAARHGAEVTPAQVALAWVLGRGRHVVPVPGAKRERWAVENAGAAGLRLTAADLAEIAALPAPRGSWD
>NZ_CP029197.1|WP_041662897.1|5601895_5602834_+|2-hydroxyacid-dehydrogenase
MWLPIPADEIDDLPGPGESGLNYRFWDGGPEFPADPARCAFYVVPYMKGPEIAVRPLAAMTSVRIVQTLSAGIDHVTPGIDALPPGVALCNAKGVHEASTAELTLALILASLRGIPGFVRGQDAEEWRAGFYPALADKSVLIVGYGSIGAAIEDRLAPFECARVVRVARSARTTARGPVHPLAELPALLPQADVVVLSTPLTPETRHLADAGFLARMKDGALLVNVARGPVVDTAALLKEVETGRITAALDVTDPEPLPAGHPLWHAPGVLVSPHVGGSTSAFMPRAKRLIAGQLRRFAAGEEPVNVLLTTT

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Crispr_ID: NZ_CP029197_20

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_20

5787979-5788081

Orphan

Consensus_repeat	Method
TCGCGGCCGCACGGCCCGTCGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_20

>merge|NZ_CP029197|20|5787979-5788081|CRISPRCasFinder
TTGCGGCCCCGCGCCCCGTCGCGGCCGCACGGCCCGTCGTGGCCGCCACGGTCCCGCGCCCCGCGCCCCGTCGCGGACTTCGCGTCCGCACGGCCCGTCGTGG

>NZ_CP029197|20|18|5787979-5788081|CRISPRCasFinder
TTGCGGCCCCGCGCCCCGTCGCGG	CCGCACGGCCCGTCGTGGCCGCCACGGTCCCGCGCCCCGCGCCCCGTCGCGGACT
TCGCGTCCGCACGGCCCGTCGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015036543.1\|5796502_5796796_+\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364
NZ_CP029197.1\|WP_041662923.1\|5788111_5789053_-\|slipin-family-protein	unknown	unknown	gnl\|CDD\|259808
NZ_CP029197.1\|WP_071891525.1\|5792800_5793082_+\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|377288
NZ_CP029197.1\|WP_015036535.1\|5786256_5787957_+\|proline--tRNA-ligase	unknown	unknown	gnl\|CDD\|236405
NZ_CP029197.1\|WP_015036532.1\|5783485_5784643_+\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl\|CDD\|234737
NZ_CP029197.1\|WP_015036527.1\|5776629_5778552_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173850
NZ_CP029197.1\|WP_015036530.1\|5780818_5782078_+\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl\|CDD\|235472
NZ_CP029197.1\|WP_015036537.1\|5789099_5789999_-\|kinase	unknown	unknown	gnl\|CDD\|309685
NZ_CP029197.1\|WP_015036533.1\|5784766_5785612_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379120
NZ_CP029197.1\|WP_015036531.1\|5782074_5783382_+\|site-2-protease-family-protein	unknown	unknown	gnl\|CDD\|100084
NZ_CP029197.1\|WP_069202173.1\|5778672_5779314_+\|PE-PGRS-family-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_071891528.1\|5793232_5796331_+\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401
NZ_CP029197.1\|WP_015036538.1\|5790045_5790462_-\|DUF4439-domain-containing-protein	unknown	unknown	gnl\|CDD\|373114
NZ_CP029197.1\|WP_015036529.1\|5779548_5780784_+\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|238797
NZ_CP029197.1\|WP_015036544.1\|5796826_5797267_+\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NZ_CP029197.1\|WP_015036540.1\|5791221_5791728_+\|ribosome-maturation-factor-RimP	unknown	unknown	gnl\|CDD\|234627
NZ_CP029197.1\|WP_015036534.1\|5785641_5786187_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_CP029197.1\|WP_015036526.1\|5774977_5776423_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143465
NZ_CP029197.1\|WP_015036539.1\|5790458_5791043_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP029197.1\|WP_015036541.1\|5791730_5792726_+\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_041662923.1\|5788111_5789053_-\|slipin-family-protein	gnl\|CDD\|259808	cd08826, SPFH_eoslipins_u1, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria and archaebacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial and archaebacterial SLPs remain uncharacterized. This subgroup contains PH1511 from the hyperthermophilic archaeon Pyrococcus horikoshi.	4.54269e-94
NZ_CP029197.1\|WP_071891525.1\|5792800_5793082_+\|YlxR-family-protein	gnl\|CDD\|377288	pfam04296, DUF448, Protein of unknown function (DUF448).	5.40662e-25
NZ_CP029197.1\|WP_015036535.1\|5786256_5787957_+\|proline--tRNA-ligase	gnl\|CDD\|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP029197.1\|WP_015036532.1\|5783485_5784643_+\|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl\|CDD\|234737	PRK00366, ispG, flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.	0
NZ_CP029197.1\|WP_015036527.1\|5776629_5778552_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173850	cd01161, VLCAD, Very long chain acyl-CoA dehydrogenase. VLCAD is an acyl-CoA dehydrogenase (ACAD), which is found in the mitochondria of eukaryotes and in some bacteria. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. VLCAD acts as a homodimer.	3.51886e-96
NZ_CP029197.1\|WP_015036530.1\|5780818_5782078_+\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl\|CDD\|235472	PRK05447, PRK05447, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional.	0
NZ_CP029197.1\|WP_015036537.1\|5789099_5789999_-\|kinase	gnl\|CDD\|309685	pfam04655, APH_6_hur, Aminoglycoside/hydroxyurea antibiotic resistance kinase. The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.	2.14936e-57
NZ_CP029197.1\|WP_015036533.1\|5784766_5785612_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379120	pfam13312, DUF4081, Domain of unknown function (DUF4081). This domain is often found N-terminal to the GNAT acetyltransferase domain, pfam00583 and FR47, pfam08445.	1.00236e-51
NZ_CP029197.1\|WP_015036531.1\|5782074_5783382_+\|site-2-protease-family-protein	gnl\|CDD\|100084	cd06163, S2P-M50_PDZ_RseP-like, RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog RseP is involved in the sigmaE pathway of extracytoplasmic stress responses. Also included in this group are such homologs as Bacillus subtilis YluC, Mycobacterium tuberculosis Rv2869c S2P, and Bordetella bronchiseptica HurP. Rv2869c S2P appears to have a role in the regulation of prokaryotic lipid biosynthesis and membrane composition and YluC of Bacillus has a role in transducing membrane stress. This group includes bacterial and eukaryotic S2P/M50s homologs with either one or two PDZ domains present. PDZ domains are believed to have a regulatory role. The RseP PDZ domain is required for the inhibitory reaction that prevents cleavage of its substrate, RseA.	1.6672e-47
NZ_CP029197.1\|WP_015036541.1\|5791730_5792726_+\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0
NZ_CP029197.1\|WP_071891528.1\|5793232_5796331_+\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NZ_CP029197.1\|WP_015036538.1\|5790045_5790462_-\|DUF4439-domain-containing-protein	gnl\|CDD\|373114	pfam14530, DUF4439, Domain of unknown function (DUF4439). This domain has a ferritin-like fold.	2.0022e-26
NZ_CP029197.1\|WP_015036529.1\|5779548_5780784_+\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|238797	cd01556, EPSP_synthase, EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.	1.75462e-142
NZ_CP029197.1\|WP_015036544.1\|5796826_5797267_+\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.17479e-47
NZ_CP029197.1\|WP_015036540.1\|5791221_5791728_+\|ribosome-maturation-factor-RimP	gnl\|CDD\|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	2.77983e-50
NZ_CP029197.1\|WP_015036534.1\|5785641_5786187_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.59075e-07
NZ_CP029197.1\|WP_015036526.1\|5774977_5776423_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143465	cd07147, ALDH_F21_RNP123, Aldehyde dehydrogenase family 21A1-like. Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) was first described in the moss Tortula ruralis and is believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and ALDH21A1 expression represents a unique stress tolerance mechanism. So far, of plants, only the bryophyte sequence has been observed, but similar protein sequences from bacteria and archaea are also present in this CD.	0
NZ_CP029197.1\|WP_015036539.1\|5790458_5791043_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	6.21473e-05
NZ_CP029197.1\|WP_015036543.1\|5796502_5796796_+\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	3.83413e-35

>NZ_CP029197.1|WP_015036535.1|5786256_5787957_+|proline--tRNA-ligase
MANAPVQRMSQLMAKTLRDDPADAEVLSHKLLVRAGYVRRTAAGIWSWLPLGKKVLSNIERIVREEMDAIGAQEVTLPALLPREPYEATGRWDEYGAELFRLQDRKGGDYLLGPTHEEIFTLLVKDQCSSYKDLPVILYQIQNKFRDEARPRAGILRGREFLMKDSYSFDTEDEGLAQSYALHRQAYQRVFERLGLDYRIVAATAGAMGGSKSEEFLAPAEAGEDTFADCPNCDFAANTEAISYELQPVDGSAVPAAEEIPTPDTPTIETLAASLGVPASATLKNLLVKVDGEIVAVGVPGDREVDMGKVEEHFAPATVEMVTESDFAARADLVRGYVGPQGLEKVTYIADPRVAPGTAWITGANKDGMHAKNVVAGRDFEVEEYVDVVVVQEGDPCPKCGTGLKLDRAIEIGHIFQLGRKYADALKLDVLGQNGKPVRVTMGSYGIGVSRAVAALAEQTADEKGLCWPAEVAPADVHVVAAGKALQTELALEVSDKLSAAGLRVLVDDRAGVSPGVKFTDAELMGVPKILVAGRRSGEGIVELKDRRTGDREELTVEEALTRLTA
>NZ_CP029197.1|WP_015036534.1|5785641_5786187_+|GNAT-family-N-acetyltransferase
MDDAEVMIGPVNLAARVDEALAVQAVAFGLDEDEIAVRRHIVLRHLMSPGARAYGATTGDGRLVGFVYGMPNDRSHWWSTVVETYLRATGTADWLDDSFVITELHVHPAHQGRGVGRELITTITDTAEEPRSILSAIDTESPARGLYRSLGYEDLARQVHFPSAARPYAVMGAPLPLKRRN
>NZ_CP029197.1|WP_015036533.1|5784766_5785612_+|GNAT-family-N-acetyltransferase
MLTQPATRVLEPADLGAALAVLESAPVENAFVTARVQVAGLDPWRLGGEMWGWYSEGRLRSLCYSGANLVPLCATPEAVRAFADRARRTGRRCSSIVGPAEPTTELWRLLEPSWGPARDVRAHQPLMVAEAPSSTVAPDPLVRRVRKDEMEVIMPACVAMFTEEVGISPLANDGGLLYQARVAELVGSGRSFARIEDGKVIFKAEIGAATRQACQIQGVWVAPEHRGKGLSESGMAAVLQYALADVAPVVSLYVNDYNTPARASYRRVGFQETGAFMSVLF
>NZ_CP029197.1|WP_015036532.1|5783485_5784643_+|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MTAISLGIPTVPTRLAERRKSRQIQVGSVAVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALAVIAKKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKQFDDKVKEIAKAASDARTPIRIGVNAGSLDARLLKKYGRATPEALVESALWEASLFEEHGFRDIKISVKHNDPVIMVEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEIKVGMQILESLNLRQRRLEIVSCPSCGRAQVDVYKLAEEVTAGLDGMTVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEALKIAEQMEKDGVASGEPSVAVAG
>NZ_CP029197.1|WP_015036531.1|5782074_5783382_+|site-2-protease-family-protein
MTELLLYALGIVLFALGLLVSIAWHELGHLSTAKLFGIRVPQYMVGFGPTIWSRKRGETEYGIKAIPAGGYIRMIGMFPPGEDGKIEARSTSPWRSMIEDAREASYEELKPGDETRLFYTRKPWKRVIVMFAGPFMNLVLAVVLFFGSMMTLGIEGQTTQVAGVQKCVIEQDEKRDKCAAGDPVSPAFKAGLKDGDRIVAFNGTPVNDWDTLSDRIRDTIGPATVTVERAGQRIDLHPTLVPNKVLAKDEDGKVVQPAKYVAAGYLGFASKTEVAPLTFGETTDRMGDLLENGVHSVIALPGKIPGLWDATFGDGERADDSPVGVVGAARITGELMNVEAPPTTILVMFMNLLVGFNVSLFLFNMLPLLPLDGGHIAGALWESVRRHTARIFKRPDPGPFDVAKLMPAAYVVAGVFVCFTLLVLAADLVNPVRIT
>NZ_CP029197.1|WP_015036530.1|5780818_5782078_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MSDRPSPLADPRSVFSPVDGDAGRRDIVVLGSTGSIGTQAIDLVLRNPDRFRVTALAASGGRVALLAEQAHRLKVAAVAVAREEVLPELREALKALYGSEPLPELLAGPDAATQLAASPCHTVLNGITGSIGLAPTLAALEAGRTLALANKESLIVGGPLVKALAKPGQIIPVDSEHAALFQALAAGTRADVRKLVVTASGGPFRGRTREELAHVTREDALAHPTWAMGPVITVNSATLVNKGLEVIEAHLLYDIPFDRIEVVVHPQSYVHSMVEFTDGSTLAQATPPDMRGPIAIGIGWPERVPDAAPAFDWTKASTWEFFPLDTEAFPSVGLARHVGGLGGTAPAVFNAANEECVEAFLAGRLPFNGIMDTVTAVVAEHGVPASGTSLTVPDVLEAETWARARARELAAKATAEARA
>NZ_CP029197.1|WP_015036529.1|5779548_5780784_+|3-phosphoshikimate-1-carboxyvinyltransferase
MTVIDIPGSKSVTARALFLAAAAQGTTTLLRPLVSDDTEGFAEGLGSLGYAVRRESDAWHIEGRPAGPGADTADVYCRDGATTARFLPTLVAAGHGTYRFDASPQMRRRPLGPLSTALRTLGVDLRHGGKDGHHPLDVHAHGVKGGALTLDAGQSSQYLTALLMLGPLTAEGLDITVTDLVSEPYVEITLAMMRSFGAEVTQEGRTYRVAPTGYRARTYGIEPDASTASYFFAAAALEPGRSVTVPGLGTGALQGDLGFVDVLRRMGADVEITDAGTTVRSTGTLRGLTVNMRDISDTMPTLAAIAPFADGPVRIEDVANTRVKECDRLDACAENLRRLGITVETGPDWIEIHPGTPTGPAEIATHGDHRIVMSFAVTALRTPGITFDDPGCVKKTFPDFHRVFDAFVHTP
>NZ_CP029197.1|WP_069202173.1|5778672_5779314_+|PE-PGRS-family-protein
MADTDATAGAAPAPEDGTTVIGLGVTGVAGYARPAPRDPAREQSARAGVLGVGDQSAHSPGVAGFGEIGVIGSGSLCGVHGRGETGVRGETLFSEGVYGVARATGAGVVGESKDGPGVLASSRTDAGLRAQSVTDVGGVFSSGNGAQIELTPLLADDPDVTVRLPAAGRLGQLAALSDDGSTCRLYLCVQAPENAPAHWAEIQLGPPVEGGPQ
>NZ_CP029197.1|WP_015036527.1|5776629_5778552_+|acyl-CoA-dehydrogenase
MSAPTQRPKVTAHEARQTAEAARERDWHKPSFAKELFLGRFRLDLVHPHPLPADEDVRRGEAFLAALREFCETRIDGARIEREARVPDETITGLKELGALGMKIDRKYGGLGLTQLYYNRALALVGSASPAVGALLSAHQSIGVPQPLKLFGTQEQKDAFLPRLARTDISAFLLTEPDVGSDPARLATSAVPDGDSYVLDGVKLWTTNGVIADLLVVMARVPASDGHPGGITAFVVEADSPGITVEHRNAFMGLRGLENGVTRFHGVRVPAANRIGPEGAGLKIALTTLNTGRLSLPAACAGAGKWCLRIAREWAGVREQWGGPVGRHEAVGTKISFIAATTFALEAVVDLASQMADEDRNDIRIEAALAKLYGSEMAWLIADELVQIRGGRGYETADSLAARGERAVPAEQLLRDLRINRIFEGSTEIMHLLIAREAVDAHLSVAGDLIDPGASLADKAKAGARAGGFYARWLPGLVTGPGQLPGSYAEFGALAGHLRYVERTSRKLARSTFYAMSRWQGRMELKQAFLGRIVDIGAELFAMSAACVRAEHLRDTGDHGAEAHQLADAFCRQARLRTEELFGRLWSNTDDVDRRVADGVLAGRYTWLEQGIVDPSDEGPWIADATPGPATGEDVHRRVP
>NZ_CP029197.1|WP_015036526.1|5774977_5776423_+|aldehyde-dehydrogenase-family-protein
MTTTHAFWLAGREATGEATFDVTNSFDGRLVGKVSVPTEAQVEEAVAAAHAVVDEFAATPAHVRAAALDHVSKRLAERTEEIALVISAENGKPIKWARGEVGRAVSVFRFAAEEARRWNAGEAQRLDTEAGGAGRLALTRRIPKGVVLGIAPFNFPLNLSAHKVAPAIAVGAPIILKPAPSTPISSLILGELLAETDLPAGSWSILTVPNDRMPALVQDERLPVISFTGSDKVGYAIQQSVPHKHCTLELGGNAAAVVLPDWSSEEDLDWAASRIATFSNYQGGQSCISVQRVIVDSSVHDRLLPKIVAAVEAQVTGDPSDAATDVGPLVDEAAAQRVESWVDEAVAAGAKLLVGGKREGATYAPTVLTELPADVTLARSEVFGPVLTIAVVDGEAEAFAAVNDSDFGLQAGVFTHDLQAAFRAHRALEVGGVIVGDVPSYRADQMPYGGAKRSGVGREGVKYAMDDYTYERVLVLTGLAL
>NZ_CP029197.1|WP_041662923.1|5788111_5789053_-|slipin-family-protein
MIEELLMAAAGAGAAVAVYAGVAARVVKQYERGVVFRFGRLRDEVRTPGFTMIVPGVDRLHKVNMQIVTMPVPAQEGITRDNVTVRVDAVVYFKVVDAAEALVRVEDYKFAVSQMAQTSLRSIIGKSDLDDLLSNREKLNQGLELMLDSPAIGWGVQIDRVEIKDVSLPETMKRSMARQAEADRERRARVINADAELQASKKLAEAAQAMSGQPAALQLRLLQTVVAVAAEKNSTLVLPFPVELLRFLERATPGPEGRDAAAAQGQGQGQEATPPPISSAYLKGAADAAAGVEPVEDLTGASVEPAPREEGSG
>NZ_CP029197.1|WP_015036537.1|5789099_5789999_-|kinase
MGFEPPQRLIRTLGETYGDAVAAEWLGTLPGLAEQAIDHASLDAERVMAPGGRSSLVVLVRRSDGSPAALKIAPPFTRPDLERDALAHWNGWGAVQLLDEAADGALLLERLHPEVSLRSLPEAKALLEAAGTVRRLWVEPAEGHGFETVAERTGRQASAMTPHLSAAATAELTTAALAAREELVAGPSEALLLHGNFRQGKVLGGDRAPWLAVGPEPLVGERAYDLARLVRDRVEDLVAASSGASAARRRVNKLADSLDLDRERLRGWTLFRAVESGTRALTAGRRQDAELLLEFASWL
>NZ_CP029197.1|WP_015036538.1|5790045_5790462_-|DUF4439-domain-containing-protein
MSALDATQAALAAEHAAVYGYGVVGGRVGAGRRAEATAAYEAHRARRDALRRTVRDLGGTPVVAEAAYALPFRVADPAAAARLAAVLEDRVAGVYSDLVRAAEGPQRREAAAALREAAVRAVRWRGSDVTFPGLAERV
>NZ_CP029197.1|WP_015036539.1|5790458_5791043_-|hypothetical-protein
MTTTGRRALLTAGVSAAAAAALSGCTSEAPGPRAPSAAEREAERVARAEAALRLRSVTTSRALLERYDATLAAHPALAPRLGALRSSVAAHAKALGEGGTTVRPATAGPNATAAPASTAAPTATAGKAGPAPTAAPVPADPRAALGELAAAERAAADAHTTTLLTAPPEYARLLASVAAAGAAHAYLLTEGAPA
>NZ_CP029197.1|WP_015036540.1|5791221_5791728_+|ribosome-maturation-factor-RimP
MSTTQSDRLRGLVEPLVAAKNLDLEEIEVSRAGRRGLLRIVVDSDEGVELDACAELSRAISEKLDETDAMGEGEYVLEVSSPGADRPLTQHRHYVRATGRLVKLQLSSDGAAEELVARIVAVDEDGLDLEVPGVKGRKPTARRVEFADVAKARVEIEFNRKDKKEEEA
>NZ_CP029197.1|WP_015036541.1|5791730_5792726_+|transcription-termination/antitermination-protein-NusA
MDIDVKLLKGLAHEKEISFDLLVEAIESALLIAYHRTPDARRHARVELDRVTGHVTVWAKEDPSELEEGQEPKDFDDTPSDFGRIAASTARQVIQQRLRDAENDVTFGEYARREGDVVAGVVQQGKDPKNVLVKLDDKLEAILPVQEQVPGEEYSHGLRLRTYVVRVAKGVRGPSVTLSRTHPNLVKKLFALEVPEIADGSVEIAAIAREAGHRTKIAVRSTRSGLNPKGACIGPMGSRVRNVMAELLGEKIDIVDWSDDPAEMVANALSPARVSKVEVVDMAARSARVTVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEPSGPQD
>NZ_CP029197.1|WP_071891525.1|5792800_5793082_+|YlxR-family-protein
MSGRTHARACPERTCVGCRVRAAKSDLLRIVVTKDECVPDHRGTLPGRGAYLHPAVACLDLAVRRRAFPRAFKAQGPLDTAELRRHVERSAPQ
>NZ_CP029197.1|WP_071891528.1|5793232_5796331_+|translation-initiation-factor-IF-2
MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDALQGPGGNAGKTAAKPGAPRKAAPSPAAPSPAAAARPAAPKPGAPAPKPAPAAPAAPAPVTPAAPASSTPSPAPAASGPRPGPKPAPKPATPAPAAPEFTAPPSAPAAGQRPGGATPGPRPAGERPARPGQGAPRPQGQGAPRPQGQGAPRPGGARPAGPRPGNNPFTSGGSTGMARPQTPRPGGGAPRPGGPGAVPGAPRPQGGPGGAPRPQGQGGARPTPGGMPRPQAPRPGGAPGGNRPNPGMMPQRPAAGPRPGPGGGGRGPGGPGGRPGGPGGGGGGRPGFAGRPAGPGGGGGGFAGRPGGPGGGGGRPGGPGGGGGGFGGRPGGFGGRPGGPGGRGGTQGAFGRPGGPARRGRKSKRQRRQEYEAMQAPSVGGVMLPRGSGETIRLSRGASLTDFAEKIGANPASLVAVMMNLGEMVTATQSVSDDTLQMLGDEMNYQVQIVSPEEEDRELLESFDIEFGEDEGGEEALVSRPPVVTVMGHVDHGKTRLLDAIRKTNVVAGEAGGITQHIGAYQVGTEVNGEERRITFIDTPGHEAFTAMRARGAKSTDIAILVVAANDGVMPQTIEALNHAKAAGVPIVVAVNKIDVEGADPTKVRGQLTEFGLVAEEYGGDTMFVDISAKQGLHIDSLLEAVILTADASLDLRANPNQDAQGIAIESHLDRGRGAVSTVLVQRGTLRIGDTVVVGDAYGRVRAMLDDKGNNVEEATPSTPVLVLGLTNVPGAGDNLLVVDEDRTARQIAEKRAARERNAAFAKRVRRVSLEDLDKVLKAGLVQELNLIIKGDASGAVEALEASLLQLDVGEEVDIRVLHRGVGAVTESDIDLAMGSDAIVIGYNVRAAGRAAQMAEREGVDVRYYSVIYQAIEEIEAALKGLLKPEYEEVELGTAEIREVFRSSKLGNIAGVLIRSGEVKRNTKARLVRDGKVIAEDLTIHGLRRFKDDVTEIREGFEGGINLGNFNDIKIDDVIATYEMREKPRA
>NZ_CP029197.1|WP_015036543.1|5796502_5796796_+|DUF503-domain-containing-protein
MYVGTLSFDLLLGDVRSLKEKRSVVKPIVAELQRKFAVSVAEVSAQNLHRRAEIGVAMVSGDTGHLSDVLDRCERLVAARPEVELLSVRRRLHTDED
>NZ_CP029197.1|WP_015036544.1|5796826_5797267_+|30S-ribosome-binding-factor-RbfA
MADNARAKKLADLIREVVAEKLQRGIKDPRLGTHVTITDTRVTGDLREATVFYTVYGDDEERASAAAGLESAKGILRSAVGRAAGTKFTPTLSFVADALPENAKTIEDLLDKARASDAQVREASSGASFAGDADPYKKPGEDEAAE

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Crispr_ID: NZ_CP029197_21

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_21

5800172-5800308

Orphan

Consensus_repeat	Method
GCCCGCCCCGCCGAGCGG	CRT

3 spacers

The CRISPR arrays of NZ_CP029197_21

>merge|NZ_CP029197|21|5800172-5800308|CRT
CAGCGCCCCGCCACGCCGACCGGACCGACGGCGGGCCCGCCCGAGCCCGCCCCGCCGAGCGGGGCCGTGGCCCCGGGTGCGCCCGCCCCGCCGACCGGACCGACGGCGGGCCCGCCCGAGCCCGCCCCGCCGAGCGG

>NZ_CP029197|21|3|5800172-5800308|CRT
CAGCGCCCCGCCACGCCG	ACCGGACCGACGGCGGGCCCGCCCGA
GCCCGCCCCGCCGAGCGG	GGCCGTGGCCCCGGGTGC
GCCCGCCCCGCCGACCGG	ACCGACGGCGGGCCCGCCCGA
GCCCGCCCCGCCGAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_078508750.1\|5803119_5804412_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
NZ_CP029197.1\|WP_015036547.1\|5802116_5803085_+\|bifunctional-riboflavin-kinase/FAD-synthetase	unknown	unknown	gnl\|CDD\|235536
NZ_CP029197.1\|WP_015036552.1\|5807984_5808950_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP029197.1\|WP_015036549.1\|5804601_5805732_+\|type-III-polyketide-synthase	unknown	unknown	gnl\|CDD\|238427
NZ_CP029197.1\|WP_015036545.1\|5797263_5798163_+\|tRNA-pseudouridine(55)-synthase-TruB	unknown	unknown	gnl\|CDD\|235113
NZ_CP029197.1\|WP_071891525.1\|5792800_5793082_+\|YlxR-family-protein	unknown	unknown	gnl\|CDD\|377288
NZ_CP029197.1\|WP_015036544.1\|5796826_5797267_+\|30S-ribosome-binding-factor-RbfA	unknown	unknown	gnl\|CDD\|234787
NZ_CP029197.1\|WP_015036540.1\|5791221_5791728_+\|ribosome-maturation-factor-RimP	unknown	unknown	gnl\|CDD\|234627
NZ_CP029197.1\|WP_015036556.1\|5813040_5816502_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|223531
NZ_CP029197.1\|WP_015036538.1\|5790045_5790462_-\|DUF4439-domain-containing-protein	unknown	unknown	gnl\|CDD\|373114
NZ_CP029197.1\|WP_015036550.1\|5805820_5806918_+\|large-tegument-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP029197.1\|WP_041664241.1\|5811006_5812848_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173853
NZ_CP029197.1\|WP_015036537.1\|5789099_5789999_-\|kinase	unknown	unknown	gnl\|CDD\|309685
NZ_CP029197.1\|WP_015036554.1\|5809941_5811003_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_CP029197.1\|WP_106433889.1\|5808946_5809840_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
NZ_CP029197.1\|WP_015036551.1\|5806974_5807988_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP029197.1\|WP_015036541.1\|5791730_5792726_+\|transcription-termination/antitermination-protein-NusA	unknown	unknown	gnl\|CDD\|237061
NZ_CP029197.1\|WP_071891528.1\|5793232_5796331_+\|translation-initiation-factor-IF-2	unknown	unknown	gnl\|CDD\|235401
NZ_CP029197.1\|WP_015036539.1\|5790458_5791043_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP029197.1\|WP_015036543.1\|5796502_5796796_+\|DUF503-domain-containing-protein	unknown	unknown	gnl\|CDD\|377364

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_078508750.1\|5803119_5804412_-\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.45251e-78
NZ_CP029197.1\|WP_015036547.1\|5802116_5803085_+\|bifunctional-riboflavin-kinase/FAD-synthetase	gnl\|CDD\|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	3.01718e-149
NZ_CP029197.1\|WP_015036552.1\|5807984_5808950_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.27448e-144
NZ_CP029197.1\|WP_015036549.1\|5804601_5805732_+\|type-III-polyketide-synthase	gnl\|CDD\|238427	cd00831, CHS_like, Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy, after the starter molecule is loaded onto the active site cysteine, a carboxylative condensation reation extends the polyketide chain. Plant-specific PKS are dimeric iterative PKSs, using coenzyme A esters to deliver substrate to the active site, but they differ in the choice of starter molecule and the number of condensation reactions.	2.71934e-104
NZ_CP029197.1\|WP_015036545.1\|5797263_5798163_+\|tRNA-pseudouridine(55)-synthase-TruB	gnl\|CDD\|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	4.73403e-165
NZ_CP029197.1\|WP_071891525.1\|5792800_5793082_+\|YlxR-family-protein	gnl\|CDD\|377288	pfam04296, DUF448, Protein of unknown function (DUF448).	5.40662e-25
NZ_CP029197.1\|WP_015036544.1\|5796826_5797267_+\|30S-ribosome-binding-factor-RbfA	gnl\|CDD\|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.17479e-47
NZ_CP029197.1\|WP_015036540.1\|5791221_5791728_+\|ribosome-maturation-factor-RimP	gnl\|CDD\|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	2.77983e-50
NZ_CP029197.1\|WP_015036556.1\|5813040_5816502_-\|AAA-family-ATPase	gnl\|CDD\|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	1.95576e-46
NZ_CP029197.1\|WP_015036538.1\|5790045_5790462_-\|DUF4439-domain-containing-protein	gnl\|CDD\|373114	pfam14530, DUF4439, Domain of unknown function (DUF4439). This domain has a ferritin-like fold.	2.0022e-26
NZ_CP029197.1\|WP_015036550.1\|5805820_5806918_+\|large-tegument-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	4.08163e-10
NZ_CP029197.1\|WP_041664241.1\|5811006_5812848_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	6.04636e-110
NZ_CP029197.1\|WP_015036537.1\|5789099_5789999_-\|kinase	gnl\|CDD\|309685	pfam04655, APH_6_hur, Aminoglycoside/hydroxyurea antibiotic resistance kinase. The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.	2.14936e-57
NZ_CP029197.1\|WP_015036554.1\|5809941_5811003_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.38241e-109
NZ_CP029197.1\|WP_106433889.1\|5808946_5809840_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.07347e-86
NZ_CP029197.1\|WP_015036551.1\|5806974_5807988_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.29942e-117
NZ_CP029197.1\|WP_015036541.1\|5791730_5792726_+\|transcription-termination/antitermination-protein-NusA	gnl\|CDD\|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0
NZ_CP029197.1\|WP_071891528.1\|5793232_5796331_+\|translation-initiation-factor-IF-2	gnl\|CDD\|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
NZ_CP029197.1\|WP_015036539.1\|5790458_5791043_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	6.21473e-05
NZ_CP029197.1\|WP_015036543.1\|5796502_5796796_+\|DUF503-domain-containing-protein	gnl\|CDD\|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	3.83413e-35

>NZ_CP029197.1|WP_015036545.1|5797263_5798163_+|tRNA-pseudouridine(55)-synthase-TruB
MSNARQTPDGLVIVDKPSGFTSHDVVAKMRGIAKTRRVGHAGTLDPMATGVLVLGVERATKLLGHLALTEKEYLGTIRLGQTTITDDAEGEITASVDASKVTREGIDAGVAELTGAIMQVPSKVSAIKIDGKRSYARVRGGEEFEIPARPVTVSSFQVYDVREATAEDGTPVVDLVVSVVCSSGTYIRALARDLGAGLGVGGHLTALRRTRVGPYKLDSAKTLDQLQEELTVMPVADAASAAFPRWDVDEKRAKLLLNGVRLEMPTYPAGPVAVFGPEGKLLALVEDQRGKAKSLAVFG
>NZ_CP029197.1|WP_015036544.1|5796826_5797267_+|30S-ribosome-binding-factor-RbfA
MADNARAKKLADLIREVVAEKLQRGIKDPRLGTHVTITDTRVTGDLREATVFYTVYGDDEERASAAAGLESAKGILRSAVGRAAGTKFTPTLSFVADALPENAKTIEDLLDKARASDAQVREASSGASFAGDADPYKKPGEDEAAE
>NZ_CP029197.1|WP_015036543.1|5796502_5796796_+|DUF503-domain-containing-protein
MYVGTLSFDLLLGDVRSLKEKRSVVKPIVAELQRKFAVSVAEVSAQNLHRRAEIGVAMVSGDTGHLSDVLDRCERLVAARPEVELLSVRRRLHTDED
>NZ_CP029197.1|WP_071891528.1|5793232_5796331_+|translation-initiation-factor-IF-2
MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDALQGPGGNAGKTAAKPGAPRKAAPSPAAPSPAAAARPAAPKPGAPAPKPAPAAPAAPAPVTPAAPASSTPSPAPAASGPRPGPKPAPKPATPAPAAPEFTAPPSAPAAGQRPGGATPGPRPAGERPARPGQGAPRPQGQGAPRPQGQGAPRPGGARPAGPRPGNNPFTSGGSTGMARPQTPRPGGGAPRPGGPGAVPGAPRPQGGPGGAPRPQGQGGARPTPGGMPRPQAPRPGGAPGGNRPNPGMMPQRPAAGPRPGPGGGGRGPGGPGGRPGGPGGGGGGRPGFAGRPAGPGGGGGGFAGRPGGPGGGGGRPGGPGGGGGGFGGRPGGFGGRPGGPGGRGGTQGAFGRPGGPARRGRKSKRQRRQEYEAMQAPSVGGVMLPRGSGETIRLSRGASLTDFAEKIGANPASLVAVMMNLGEMVTATQSVSDDTLQMLGDEMNYQVQIVSPEEEDRELLESFDIEFGEDEGGEEALVSRPPVVTVMGHVDHGKTRLLDAIRKTNVVAGEAGGITQHIGAYQVGTEVNGEERRITFIDTPGHEAFTAMRARGAKSTDIAILVVAANDGVMPQTIEALNHAKAAGVPIVVAVNKIDVEGADPTKVRGQLTEFGLVAEEYGGDTMFVDISAKQGLHIDSLLEAVILTADASLDLRANPNQDAQGIAIESHLDRGRGAVSTVLVQRGTLRIGDTVVVGDAYGRVRAMLDDKGNNVEEATPSTPVLVLGLTNVPGAGDNLLVVDEDRTARQIAEKRAARERNAAFAKRVRRVSLEDLDKVLKAGLVQELNLIIKGDASGAVEALEASLLQLDVGEEVDIRVLHRGVGAVTESDIDLAMGSDAIVIGYNVRAAGRAAQMAEREGVDVRYYSVIYQAIEEIEAALKGLLKPEYEEVELGTAEIREVFRSSKLGNIAGVLIRSGEVKRNTKARLVRDGKVIAEDLTIHGLRRFKDDVTEIREGFEGGINLGNFNDIKIDDVIATYEMREKPRA
>NZ_CP029197.1|WP_071891525.1|5792800_5793082_+|YlxR-family-protein
MSGRTHARACPERTCVGCRVRAAKSDLLRIVVTKDECVPDHRGTLPGRGAYLHPAVACLDLAVRRRAFPRAFKAQGPLDTAELRRHVERSAPQ
>NZ_CP029197.1|WP_015036541.1|5791730_5792726_+|transcription-termination/antitermination-protein-NusA
MDIDVKLLKGLAHEKEISFDLLVEAIESALLIAYHRTPDARRHARVELDRVTGHVTVWAKEDPSELEEGQEPKDFDDTPSDFGRIAASTARQVIQQRLRDAENDVTFGEYARREGDVVAGVVQQGKDPKNVLVKLDDKLEAILPVQEQVPGEEYSHGLRLRTYVVRVAKGVRGPSVTLSRTHPNLVKKLFALEVPEIADGSVEIAAIAREAGHRTKIAVRSTRSGLNPKGACIGPMGSRVRNVMAELLGEKIDIVDWSDDPAEMVANALSPARVSKVEVVDMAARSARVTVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEPSGPQD
>NZ_CP029197.1|WP_015036540.1|5791221_5791728_+|ribosome-maturation-factor-RimP
MSTTQSDRLRGLVEPLVAAKNLDLEEIEVSRAGRRGLLRIVVDSDEGVELDACAELSRAISEKLDETDAMGEGEYVLEVSSPGADRPLTQHRHYVRATGRLVKLQLSSDGAAEELVARIVAVDEDGLDLEVPGVKGRKPTARRVEFADVAKARVEIEFNRKDKKEEEA
>NZ_CP029197.1|WP_015036539.1|5790458_5791043_-|hypothetical-protein
MTTTGRRALLTAGVSAAAAAALSGCTSEAPGPRAPSAAEREAERVARAEAALRLRSVTTSRALLERYDATLAAHPALAPRLGALRSSVAAHAKALGEGGTTVRPATAGPNATAAPASTAAPTATAGKAGPAPTAAPVPADPRAALGELAAAERAAADAHTTTLLTAPPEYARLLASVAAAGAAHAYLLTEGAPA
>NZ_CP029197.1|WP_015036538.1|5790045_5790462_-|DUF4439-domain-containing-protein
MSALDATQAALAAEHAAVYGYGVVGGRVGAGRRAEATAAYEAHRARRDALRRTVRDLGGTPVVAEAAYALPFRVADPAAAARLAAVLEDRVAGVYSDLVRAAEGPQRREAAAALREAAVRAVRWRGSDVTFPGLAERV
>NZ_CP029197.1|WP_015036537.1|5789099_5789999_-|kinase
MGFEPPQRLIRTLGETYGDAVAAEWLGTLPGLAEQAIDHASLDAERVMAPGGRSSLVVLVRRSDGSPAALKIAPPFTRPDLERDALAHWNGWGAVQLLDEAADGALLLERLHPEVSLRSLPEAKALLEAAGTVRRLWVEPAEGHGFETVAERTGRQASAMTPHLSAAATAELTTAALAAREELVAGPSEALLLHGNFRQGKVLGGDRAPWLAVGPEPLVGERAYDLARLVRDRVEDLVAASSGASAARRRVNKLADSLDLDRERLRGWTLFRAVESGTRALTAGRRQDAELLLEFASWL
>NZ_CP029197.1|WP_015036547.1|5802116_5803085_+|bifunctional-riboflavin-kinase/FAD-synthetase
MQRWRGLADIPQDWGRSVVTIGSYDGVHRGHQLIIGRAVERARELGVPCVVVTFDPHPSEVVRPGSHPPLLAPHHRRAELMAGLGVDAVLVLPFTAEFSQLSPADFIVKVLVDKLHAKAVIEGPNFRFGHRAAGNVAFLTELGATYDYEVEVIDLYVSGSAGGGDPFSSTLTRRLVAEGDMTGAAEILGRPHRVEGVVVRGAQRGRELGFPTANVETLPHTAIPADGVYAGWLTAAGERMPAAISVGTNPQFDGTERTVEAYAIDREGLDLYGLHVAVDFLEYVRGMLKFDTLDDLLEAMAGDVKRCRELTEAYDREHPTAG
>NZ_CP029197.1|WP_078508750.1|5803119_5804412_-|cytochrome-P450
MTSETTSEATAGPGRGAPRPTGCPTGVAASAAAPPAARTWAVDDLPALAFDPLLTELLEKEPVARIRLPFAARNEAWLVTRYEDVRAVTSDPRFSRTALLDQQVTKMTGHMVASKAALNYADPPYHTQLRKAVTKAFTGQSTRRLRPLAQAGTDRLLDAMEAAGRPADLMKHLHGPLPMAVVCDLLGIPEEDRAELASWPDLILSSGPGPESSKAAKAQIHGYVIRLLDRRRAEPQDDLAGVLAESLAEGRITAEEAVSLAMAILISGAHAVRNNSANMVYVLLTRPELADRLRAEPGLLPQAVDELLRWIPHRNGVGLPRIATEDVEVGGVLIRAGEAVYASYLAANRDPAAFEDPDRLDFDREGIGHVSFGHGPHHCMGAMLTRMESEVMLSTLLDRYPRLRLAGSAEDVVWQSKGLIRGPKELLVTW
>NZ_CP029197.1|WP_015036549.1|5804601_5805732_+|type-III-polyketide-synthase
MVTLCKPAVSVPEHVITMEETLDLARTHHEGHPQLALALRLIGNTGVTRRHIVQPIEETLKHPGFEERNIRYEAEAKARVPAVVNEALENAGLRPADIDMIVYVSCTGFMMPSLTAWMINTMGFPSNTRQVPIAQLGCAAGGAAINRAHDFCTAYPDANVLIVACEFCSLCYQPTDLGVGSLLSNGLFGDAVAAAVVRGRGGTGIGLERNSSHLVPDTEDWIAYSVRATGFHFLLDKRVPGTMEPLAPALREVAGAHGWDAGELDFYIIHAGGPRILDDLSRFLEVPPDAFRFSRATLTEYGNIASAVVLDAVRRLFEEGGQPEGARGILAGFGPGITAEMCLGRWTTSPVSPEPNLGTRRIVGYSPFRPARTSVA
>NZ_CP029197.1|WP_015036550.1|5805820_5806918_+|large-tegument-protein
MSAMPPSGRRRRPRALRGPAAITALLAGAAAASLAAAPAGAAGPNGVRVPMHQCWVNGVTAPPGDIVSGTSGDDNIFCDSDLENVTVWGGAGNDMIEVRGLVIDSAVMGGDGDDVIRTKHLVPQNASSMVRGNRGNDVIKVATVSGDGATKGAVVHGDDGDDRITTGSVTGAPGKYNRGGGIVTGNDGADTIKVGTVDFSGRVLGGSGADVIEAEALGPESGGLIQSGPGDDTISGPDGAVLIVGEHWGTVDAGVGRDTCTVKSVSTRTSISACEIMPKAAPAADRPSGQLTPAAPTGTTAEPPSKPAAPAATPAKPAAPAAVPAAPAGPAEPAAPPAGPVEPVTAAAGPVEPVAPAAPVGPAGP
>NZ_CP029197.1|WP_015036551.1|5806974_5807988_-|ABC-transporter-ATP-binding-protein
MSTETAVRTEKPALLSARGLHVTFPGRRGAPPARAVDGVDLDIAPGEIVALVGESGCGKTTLARSLLGLVRPTSGTVSFDGKPLGYASGALKAYRKRAQLVLQDPSGSLNPRHTVYDAVAEGLRIHGVRAGTDEREAVAGALARAGLRPPKRFFLRYPHELSGGQRQRVVIAGALVLEPELIVADEPVASLDASVRGEILALLLRLRDELGLSALVVTHDLGLAWNIADRVAVMYLGRVVETGTVESVLTRPQHPYTQALLSVLPESGGAPVVLTGEPPDPSRIPSGCRFHARCQVLASGEAAAIAHRCRGESLPILSGGPEQAVACHWATREGAAP
>NZ_CP029197.1|WP_015036552.1|5807984_5808950_-|ABC-transporter-ATP-binding-protein
MSLLEVRDLRVTYGTGAAAVPAVRGVDLTLETGSKLGVAGESGCGKSTLALALLRLLPASARIEGRILLDGDDVLAMKWGRLRAVRWAGASIVFQGAMHSLNAVHRIGDQIAEPLLVHGRATPAAARRRAGELLEQVGLPAARAAAYPHELSGGQRQRVMIAMALACDPRLIVADEPTTALDVMIQAQILRLIERLVAEESISLLMISHDLAVLADTCDRLAVMYAGRVVEEGPARAVYEAARHPYGRALSSAFPRIGDLASRRAPRGLPGDPPDPADLPGGCTFHPRCPVAVAACAELDQELREAGAEHRAACVHVGSAS
>NZ_CP029197.1|WP_106433889.1|5808946_5809840_-|ABC-transporter-permease
MPSAAALRWERRRTSAARFWKAYRTHRAGLYGLAGLALIAVLALTAPLLVGADVQSVTQAPGTALEAPSAEFPLGTDQFGRSLLGLLIWGARISLLVGLLAAALSVAIGTLVGIIAGHYGGWFSTVVMRITDWFLVMPTLVLAIVLATVMSRSMWTVVLAIGVTSWPTTARLVRAQTIAVESRPYIERATALGGGHGHVMSKHVLPNVMPLVLAQTTLGISTAILTEATLAFLGLGDPTVVSWGGMLQDAREAGAVSSGHWWYLAPPGIAIALVALAFTLCGRAVESVLNPKLGVGR
>NZ_CP029197.1|WP_015036554.1|5809941_5811003_-|ABC-transporter-permease
MTTASTPADVVRADEARTTDGAPRTGSSLGYLRHAAGKLGGALVSLFAVLVTSFFLFRIIPGDPVKAMTHGVPTSAEQLATLRRQFGLDLPLWQQFTDYCAKALSGDLGTSFQFRAPVGDLIAEKLPATLLLTGVAVVIYSALGLWLGTRSAWRHGGLGDKLNTGIALTLWSVPSFWLGLLLIIVFSVGIGPVPGLFPTGGMESGTGETGFAYVLDVAHHLVLPVVTLVAVGYAQTLLVMRSSLLDEMGGDYLTTARAKGLRDDDVRRRHAVPNALLPTVTMIFINLGHVAAGSILVETVFSWPGLGGLFYQALSVPDLPLVQGLFVVFAGAMILMNLIADLLYPLLDPRVGR
>NZ_CP029197.1|WP_041664241.1|5811006_5812848_-|ABC-transporter-substrate-binding-protein
MVTKAPPRSAPAAHRALRLLLASGVTAVSLVAVPGTAAAEDDKSAGNTLTVAVSQSIDSLSPFLAQKLTSTSIHRLAYEYLTNYDAKDARTIPGLATAWTPSADKLTWTYTIRENSKWSDGKPATAEDAAWTFNKMMTDPNAATANGSFTANFAQVTAPDAKTLVIRLKKPQATMTALDVPIVPKHVWEKVGDFSKFNNDQQFPIVGNGPFVITDFKVDQYIKLKPNKTFWRGAPKFDELVFKYYKDGDAAVAALQKGEVSFVPNLTPAQAAALATQKNIKVNDAPGRRFYALATNPGARSQDGKTFGNGHKALLDPEVRKALFLAVDRATLVDKVFQGHAVEGEGYIPPRFGSYFWKPDAGQKRTYDPAAAERVLDAAGYKKNAAGKRLGKDGKPLDFRILCHATDPNDKAVGKYLQEWWGKLGIGLKVECLDSVSDPWVKGDYDLAFDGWSVNPDPDYVLSIHTCGTLPETPKDSGATDNFICDQEFDGLYAQQAVEYDAAKRADLVKRMQSRLYDTGYMNVMAYPNALEAYRTDQIKSITTMPEAAGNLWGQDGYWSWWSAVPAASASGDSGSGGSSTGVIVGIGAAVVVVVGLGVLLGLRRRSTADDRE
>NZ_CP029197.1|WP_015036556.1|5813040_5816502_-|AAA-family-ATPase
MNGDRDEIHGGWNPPADDQSDADPAEMTGEFTIDYTPPAWYTQNASGGAGAAGATPPPPPPSGAQVPVPGLPAGSGFEPHWNAGAPPVGTPPIGTPGMPPVGAPPGYEQPAGAAPLPVPPPVGVPAAPGPVAPGAVAPGAVAPGAVAPGPVAPGPVAPGLAAPGPAAPAPVAPASVAPAPVAPAPVAPAPGAPAAVAPGSFTPAEASAPGAFPPPVPLPVPSAPAPASTPATPFGGGDIESGATMRFSPAALQREVAERAAEAPAAAVDSGADSGTADSAAPAGAAAGAEAETAADTGSTTDEETSAAADGTASATDGSASDDSSADDSASDDSSSVDAESEETDVTDAVGAADAAEPEAEDAAAPAETTDSPEDRAPEDVAPDSGDAADPADSASPVGQPAPAALDAVTEPMAPVPYPPAAAAQAPGPFPGAAPAPAQAPAPAPAPGQPFPAAAQQPGLPPLPPSFQPAAPGPAQQWPAQPAPGAQPAPQAAPLPPAAGAWPAPAVPGAPGTVPPQAQPQPEPTPGAYGYPQPQAQQPQPAPAQPQAPGGYGYPQTPGAPQGAQPEPQPQAQGGYGFPHPGTPPQQQAGYGYPHPASVPPQAAAPQGPQPPVDPRTGAAWPSPVTHDQRERSVPGAPLGYNAAVELSSDRLLRNNKQKPKSSRTPGGAAARFKLGGKKEEAERQRKLELIRTPVLSCYRIAVISLKGGVGKTTTTTALGATLATERQDKILAIDANPDAGTLGRRVRRETGATIRDLVQAIPYLHSYMDIRRFTSQAPSGLEILANDVDPAVSTTFNDEDYRRAIDVLGKQYPIILTDSGTGLLYSAMRGVLDLADQLIIISTPSVDGASSASTTLDWLSAHGYADLVQRSITVISGVRETGKMIKVEDIVQHFQTRCRGVVVVPFDEHLSAGAEVDLDMMRPKTREAYFNLSAMVAEDFVRAQQAQGLWTGDGQGAMPPHMAPPMPGQQMPGQPVPGQPLPGQFAPGQPVPGQPYGAQPAPGQPMPGQAPPGQPLPGQFAPGQPAAGQPYPAQQPYGQAPAPGQPYGAAPAPGQPYGAQPMPGQGQPLPGQAVPGQPQPGQPYGAQPAPGQPYGAQPGQPGMPQGWQQPQPGQPLPPQADPQDQRAGDDAQVAPQNWPPQQPPQAPPAPQQ

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Crispr_ID: NZ_CP029197_22

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_22

7448590-7448761

Orphan

Consensus_repeat	Method
GGCCCGCGGCCCAACCGGCCACCAAGCCCGCCGCGAAGCCCAG	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP029197_22

>merge|NZ_CP029197|22|7448590-7448761|PILER-CR
GGCCCGCAGCGCACCCCGCGACCAAGCCGGCCGCGAAGCCCGTGGGACAGAGCGCCCGGCCCGCGGCCCCGTCGGGCACCAAGCCCGCCGCGAAGCCCAGCACCCGGCCGGCGCCCAAGCCGGTCACCAGGCCCGCGGCCAAACCGGCCGCCAAGCCCGCCGCCAAGCCCAG

>NZ_CP029197|22|1|7448590-7448761|PILER-CR
GGCCCGCAGCGCACCCCGCGACCAAGCCGGCCGCGAAGCCCGT	GGGACAGAGCGCCC
GGCCCGCGGCCCCGTCGGGCACCAAGCCCGCCGCGAAGCCCAG	CACCCGGCCGGCGCCCAAGCCGGTCACCA
GGCCCGCGGCCAAACCGGCCGCCAAGCCCGCCGCCAAGCCCAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_015037986.1\|7450344_7451058_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274875
NZ_CP029197.1\|WP_015037977.1\|7440528_7441797_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	unknown	unknown	gnl\|CDD\|238430
NZ_CP029197.1\|WP_051026227.1\|7455178_7456063_-\|YndJ-family-transporter	unknown	unknown	gnl\|CDD\|372935
NZ_CP029197.1\|WP_015037978.1\|7441793_7442264_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380396
NZ_CP029197.1\|WP_015037994.1\|7459758_7461108_+\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	unknown	unknown	gnl\|CDD\|274360
NZ_CP029197.1\|WP_015037974.1\|7438518_7438998_-\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176869
NZ_CP029197.1\|WP_015037976.1\|7439284_7440532_-\|ketosynthase-chain-length-factor	unknown	unknown	gnl\|CDD\|238428
NZ_CP029197.1\|WP_150253482.1\|7443687_7445349_+\|FAD-dependent-monooxygenase	unknown	unknown	gnl\|CDD\|366675
NZ_CP029197.1\|WP_015037993.1\|7457523_7459608_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP029197.1\|WP_015037973.1\|7438138_7438471_-\|TcmI-family-type-II-polyketide-cyclase	unknown	unknown	gnl\|CDD\|377397
NZ_CP029197.1\|WP_015037987.1\|7451145_7452630_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|237218
NZ_CP029197.1\|WP_106433918.1\|7456340_7457474_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP029197.1\|WP_015037981.1\|7445670_7446189_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015037989.1\|7453180_7454608_-\|lipase-maturation-factor-family-protein	unknown	unknown	gnl\|CDD\|369070
NZ_CP029197.1\|WP_015037983.1\|7446987_7447410_+\|aspartate-1-decarboxylase	unknown	unknown	gnl\|CDD\|376751
NZ_CP029197.1\|WP_015037975.1\|7438999_7439260_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|376348
NZ_CP029197.1\|WP_015037979.1\|7442331_7443453_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367961
NZ_CP029197.1\|WP_015037990.1\|7454630_7455182_-\|DUF1990-domain-containing-protein	unknown	unknown	gnl\|CDD\|378157
NZ_CP029197.1\|WP_015037988.1\|7452919_7453090_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_071892289.1\|7449080_7450088_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|283340

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_015037986.1\|7450344_7451058_+\|hypothetical-protein	gnl\|CDD\|274875	TIGR03951, Fe_III_red_FhuF, siderophore-iron reductase FhuF. Members of this protein family, including FhuF of E. coli, are siderophore ferric iron reductases that appear to play a role in iron removal from certain hydroxamate-type siderophores, including coprogen, ferrichrome, ferrioxamine B, and aerobactin. Genes occur in regularly in siderophore transport and/or biosynthesis clusters. The C-terminus includes four Cys residues in a C-C-10(X)-C-X-X-C motif that binds a 2Fe-2S cluster. Family TIGR03950 is similar, but especially in the C-terminal region, but likely acts on a different panel of siderophores. [Energy metabolism, Electron transport, Transport and binding proteins, Cations and iron carrying compounds].	1.90492e-09
NZ_CP029197.1\|WP_015037977.1\|7440528_7441797_-\|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein	gnl\|CDD\|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	0
NZ_CP029197.1\|WP_051026227.1\|7455178_7456063_-\|YndJ-family-transporter	gnl\|CDD\|372935	pfam14158, YndJ, YndJ-like protein. The YndJ-like protein family includes the B. subtilis YndJ protein, which is functionally uncharacterized. This family is found in bacteria and archaea, and is typically between 222 and 269 amino acids in length. There are two completely conserved G residues that may be functionally important.	8.86093e-69
NZ_CP029197.1\|WP_015037978.1\|7441793_7442264_-\|cupin-domain-containing-protein	gnl\|CDD\|380396	cd06991, cupin_TcmJ-like, TcmJ monooxygenase and related proteins, cupin domain. This family includes TcmJ, a subunit of the tetracenomycin (TCM) polyketide synthase (PKS) type II complex in Streptomyces glaucescens. TcmJ is a quinone-forming monooxygenase involved in the modification of aromatic polyketides synthesized by polyketide synthases of types II and III. Orthologs of TcmJ include the Streptomyces BenD (benastatin biosynthetic pathway), the Streptomyces olivaceus ElmJ (polyketide antibiotic elloramycin biosynthetic pathway), the Actinomadura hibisca PdmL (pradimicin biosynthetic pathway), the Streptomyces cyaneus CurC (curamycin biosynthetic pathway), the Streptomyces rishiriensis Lct30 (lactonamycin biosynthetic pathway), and the Streptomyces WhiE II (spore pigment polyketide biosynthetic pathway). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.78115e-57
NZ_CP029197.1\|WP_015037994.1\|7459758_7461108_+\|wax-ester/triacylglycerol-synthase-family-O-acyltransferase	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	1.1229e-104
NZ_CP029197.1\|WP_015037974.1\|7438518_7438998_-\|polyketide-cyclase	gnl\|CDD\|176869	cd08860, TcmN_ARO-CYC_like, N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains. This family includes the N-terminal aromatase/cyclase (ARO/CYC) domain of Streptomyces glaucescens TcmN, and related domains. It belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. ARO/CYC domains participate in the diversification of aromatic polyketides by promoting polyketide cyclization. They occur in two architectural forms, monodomain and didomain. Monodomain aromatase/cyclases have a single ARO/CYC domain. For some, such as TcmN, this single domain is linked to a second domain of unrelated function. TcmN is a multifunctional cyclase-dehydratase-O-methyl transferase. Its N-terminal ARO/CYC domain participates in polyketide binding and catalysis; it promotes C9-C14 first-ring (and C7-C16 second-ring) cyclizations. Its C-terminal domain has O-methyltransferase activity. Didomain aromatase/cyclases contain two ARO/CYC domains, and they biosynthesize C7-C12 first ring cyclized polyketides. These latter domains belong to a different subfamily in the SRPBCC superfamily.	4.01354e-80
NZ_CP029197.1\|WP_015037976.1\|7439284_7440532_-\|ketosynthase-chain-length-factor	gnl\|CDD\|238428	cd00832, CLF, Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein (ACP). CLFs are similar to other elongation ketosynthase domains, but their active site cysteine is replaced by a conserved glutamine.	0
NZ_CP029197.1\|WP_150253482.1\|7443687_7445349_+\|FAD-dependent-monooxygenase	gnl\|CDD\|366675	pfam01494, FAD_binding_3, FAD binding domain. This domain is involved in FAD binding in a number of enzymes.	1.80267e-124
NZ_CP029197.1\|WP_015037993.1\|7457523_7459608_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	7.68482e-49
NZ_CP029197.1\|WP_015037973.1\|7438138_7438471_-\|TcmI-family-type-II-polyketide-cyclase	gnl\|CDD\|377397	pfam04673, Cyclase_polyket, Polyketide synthesis cyclase. This family represents a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.	1.5262e-59
NZ_CP029197.1\|WP_015037987.1\|7451145_7452630_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|237218	PRK12825, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	2.14449e-13
NZ_CP029197.1\|WP_106433918.1\|7456340_7457474_+\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.10912e-06
NZ_CP029197.1\|WP_015037989.1\|7453180_7454608_-\|lipase-maturation-factor-family-protein	gnl\|CDD\|369070	pfam06762, LMF1, Lipase maturation factor. This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. The precise role of LMF1 in lipase folding has yet to be determined.	4.96979e-151
NZ_CP029197.1\|WP_015037983.1\|7446987_7447410_+\|aspartate-1-decarboxylase	gnl\|CDD\|376751	pfam02261, Asp_decarbox, Aspartate decarboxylase. Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalyzed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesized initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	5.73224e-77
NZ_CP029197.1\|WP_015037975.1\|7438999_7439260_-\|acyl-carrier-protein	gnl\|CDD\|376348	pfam00550, PP-binding, Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of the anguibactin system regulator AngR has the attachment serine replaced by an alanine.	5.61911e-07
NZ_CP029197.1\|WP_015037979.1\|7442331_7443453_-\|hypothetical-protein	gnl\|CDD\|367961	pfam04486, SchA_CurD, SchA/CurD like domain. Members of this family have only been identified in species of the Streptomyces genus. Two family members are known to be part of gene clusters involved in the synthesis of polyketide-based spore pigments, homologous to clusters involved in the synthesis of polyketide antibiotics. The function of this protein is unknown, but it has been speculated to contain a NAD(P) binding site. Many of these proteins contain two copies of this presumed domain.	1.90385e-58
NZ_CP029197.1\|WP_015037990.1\|7454630_7455182_-\|DUF1990-domain-containing-protein	gnl\|CDD\|378157	pfam09348, DUF1990, Domain of unknown function (DUF1990). This family of proteins are functionally uncharacterized.	1.19355e-60
NZ_CP029197.1\|WP_071892289.1\|7449080_7450088_-\|DMT-family-transporter	gnl\|CDD\|283340	pfam05653, Mg_trans_NIPA, Magnesium transporter NIPA. NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.	4.29904e-09

>NZ_CP029197.1|WP_015037983.1|7446987_7447410_+|aspartate-1-decarboxylase
MIRTIFKSKIHRATVTQADLHYVGSVTVDAELMEAADLLPGELVHIVDIDNGARLETYVIEGERGSGVIGINGAAAHLVHPGDLVILISYAQLADAEARTFVPRVVHVDADNRIVELGTDASAPVPGSDTVRAPHAVPAS
>NZ_CP029197.1|WP_015037981.1|7445670_7446189_+|hypothetical-protein
MRLARTGPQLALVLSALVLSASPAVAAPDGDVLVNPGKAAPGTTVTVSTTACGKETYGKGESEAGGKFHLLPGDREGVLVGTFKLPLEAASGTDTVTLKCPPRIKQTVTYQISGRPVGAVEAGFGWAAGAGEGADGDGSDVPYTLGALLLGGAAAGILIRTRRRATAARNGA
>NZ_CP029197.1|WP_150253482.1|7443687_7445349_+|FAD-dependent-monooxygenase
MTRFDSAGEATGHRTPVLIVGGSLVGLSTSLFLGRLGVPHTLVERHAATSIHPRGRGNNVRTMEVFRSAGMTLPIQEAASVLAANNGILQTPSLVGDVGEWLFKDIDPGGGIARISPAGWCLCSQNDLEPVLLKHARELGGDLRFATELMFFEQDAEGVTAQVKSRGTGEHTTIRADYLVAADGPRSPVREQLGIGQSGPGDLFHNVSITFVSRGLADVVGDRKFIVCYLTNPEADGALLPVDNREHWVFHAPWHPEHGETLEEFTDERCREHIRRAVGVPDLDVEITGRAPWHAAQRVAERYAEGRVFLAGDSAHEMPPTGAFGSNTGIQDAHNLAWKLAAVLGGWAGPGLLASYGAERRPVAETTSARAAARSVEHSHPGYAPGPGSGGPQGKKGGILSDVLGYRYPQGAVLGTDRTMPVVPDGLRLTGEPGSRAPHMWLSRAGTRVSTLDLYERSLVLLSSEDGACDWHTAATHVAQQLSVPLDSYRIGAGPAADLTPVSETDWAEVHGATPDGAVLVRPDGFVAWRSEGASADPGVVLRQALTAILGRD
>NZ_CP029197.1|WP_015037979.1|7442331_7443453_-|hypothetical-protein
MAPSGRISQSVFDGSRLRVILLLDLYEGAQQQFLDAYELMRKQVASVPGHISDQLCQSIENPSQWLITSEWESAPPFLAWVNSEEHVETVKPMHSCVRDTRSMRYSILRETSPGRPASRTAASADVPVEPRVGDGVARHALTFTVKPGSESKVAELLAGYESPQAQVDENTRLRRTSLFMHGNRVVRAVEVEGDLLVALRHVARQPQVRAVEEAINPYLEQDRDLTDPESARVFFTRAALPAVHHVVSDRPVPADLRRHALYYPAKEGQGMALARLLSHQDRAAADDPDNPVHSSTVFQRDDIVVRLVDVTGDLDLDPVASLGLKGPGKAAELERLLDGAAVGVEGSLETDRNINRLLSHADMLPVTDRSAHS
>NZ_CP029197.1|WP_015037978.1|7441793_7442264_-|cupin-domain-containing-protein
MLNQRPRIVNLSETEPNRRRGGDLRAMLTPATVGSTSGFMGLAIVQPGERIGEHYHPYSEEFVYVVSGALEVDLDGDTYALQPDQGLLIPIDVRHRFRNVGDVEARMVFHLGPLAPRPSLGHVDTEITDEAELAAAGPHLTVHDPGRVSERSGAIE
>NZ_CP029197.1|WP_015037977.1|7440528_7441797_-|beta-ketoacyl-[acyl-carrier-protein]-synthase-family-protein
MNRRVAVTGIGVVAPGGIGSRAFWDLLAAGRTATRGITLFDPVGLRSRIAAECDFDPAEHGLDPDLSRHADRYIQFAVVAAGEAVRDSGLDTDAEDPWRVAVSLGSAVGGTTRLEHDYVLVSEGGRRWDVDHRAADPKLHMAFSPSTLSSVVAEQFGARGPVQTVSTGCTSGLDAVGYAFHTIAEGRADVCISGASDSPISPITMACFDAIKATSPDNDDPEHASRPFDNNRNGFVMGEGAAVLVLEEYEHARARGAHIYCEIGGYATFGNAYHMTGLTGEGLEMSRAIDSTLDQARLDPTRIDYVNAHGSGTRQNDRHETAAVKRSLGSHAYDTPMSSIKSMVGHSLGAIGAIEVAACVLALKHQVVPPTANYETPDPECDLDYVPRDARPRKLRNVLSVGSGFGGFQSAVLLTGPGGRTR
>NZ_CP029197.1|WP_015037976.1|7439284_7440532_-|ketosynthase-chain-length-factor
MSTERPRRAVVTGIGVIAPNGLRADAYWKSVREGLGVLDRITREGCEDLPLKVAGEVRGFDPSDLIEEPFLVQTDRFSHYAMAAAQLALDDAGLVHDGPEEPFSIGVVTAAGSGGGEFGQRELQKLWGQGSKFVGPYQSIAWFYAASTGQISIRSGLKGPCGVVASDEAGGLDAIAHAARGVRRGTGAVLVGAAEAPLAPYSMVCQLGYPELSTVEDPDRAYRPFTSAACGFVPAEGGAMLVVEEESRARDRGAAVRAVVAGHGATFTGASRWEESREGLARAIRVALDEAGCAPEEVDVVFADALGVPEADRAEALAIADALGAHATRVAVTAPKAGIGRAYCGAPVLDTAAAVLAMEHGVVPPTPNVFDICHDLDLVMSRARPAELRTALVLSRGLMGSNAALIVRRGDESAR
>NZ_CP029197.1|WP_015037975.1|7438999_7439260_-|acyl-carrier-protein
MITTALTFDELSTLMKQAAGVTVDARELEKAPDAPFTTLGLDSLGLLGIVGELENRYSVALPTDAERCKTPGEFVGLVNNALRTGV
>NZ_CP029197.1|WP_015037974.1|7438518_7438998_-|polyketide-cyclase
MAGHTDNSITIDAPLDLVWDITNDIEKWPDLFSEYASLEVLSREGDSTTFRLTMHPDASGKVWSWVSERTVDRPGRTVRARRVETGPFDHMNIRWEYEETPAGIHMRWVQDFAMKPDAPVDDAWMTDNINRNSRTQMALIRDRIEQVARDRRSAPVLPG
>NZ_CP029197.1|WP_015037973.1|7438138_7438471_-|TcmI-family-type-II-polyketide-cyclase
MHHALIVARMAPGSAPAIADVFAASDRGELPHLVGVTRRRLFQFGDVYLHLIESEQDPGPAIAKLTGHPEFRDASEKLSAYVSAYDPLTWRSPKDAMARCFYSWERDAGS
>NZ_CP029197.1|WP_071892289.1|7449080_7450088_-|DMT-family-transporter
MSPLLLSVLLALVSAVAYAAAAIVQERVAASATGPRYAPLRSPAWWGSVLLNGVGAALHVAALAYGPLSLVQPLGALTIVFALPMAALFVGRRAGRRAWRGALMATVGLAGLLSLTTGAEGRDLSDGDRWLLAGCTFGVVALLFTAAHVVGRSVLRSVVLAAAAGVSFGMASVFTKAVAEEWSPDAPLAEWTGLLVLSALAVTGLLLSQASYRGAGLAAPLATVTVVNPVAAAAVGLTLFGESFRYGAAGTVAALICGTVAAGGLVQLTLDRMTAPTDEPSAPDGARGPGPGPGPGSEGDAPGPEVRERVDVGAVPGTRPHLEVEVRARAVAGRS
>NZ_CP029197.1|WP_015037986.1|7450344_7451058_+|hypothetical-protein
MNLVESAAVGGFFALRTTPPESGGAHRPLALLYAGEDGPLHARVDRVAARLGAPERRVGASVAHLGLAARLWSTALGPAALHGRFPSLDPAELHWDGALTSPDDLWWAGSDTRPATVAALRAAVQEAHLGPLHAALRRDGHISPRLLWGNAGSALAGALRELTRWAAAHGRPEVAERAAVLVAGLLDHPDLAGTVRGPRLRRASCCLYYRCPGGGLCGDCVFDHAPRTGLEARPPAP
>NZ_CP029197.1|WP_015037987.1|7451145_7452630_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTVTEENQDYGPGLDPERLAVCLSVLDELDKLDVDHPDAIRVRRATAGIYRTVKQRRRQERRAAKTANDKAVTEATATGSAQRIDDETEGILPTSVTEEGRIAGILQRPRSCYVCKTRFVEVDYFYHQLCQKCAAQNRAKRDARADLTGKRALLTGGRAKIGMYIALRLLRDGAHTTITTRFPKDAIRRFKAMEDSADWMHRLEVVGIDLRDPAQAVALADQMTEAGPLDILINNATQTVRRLPSAYAALVEGENAALPAGELPAHHVIGAFNSGAVGELVGSSELPAGVRDLEAQQVADLALVAGNATIAKHLDGTAIDAGGLVPDVVESNTWVQSIEQISPVELLETQLCNYTAPFILISKLRPVMAEAAKKASSGRSYVVNVSAMEGVFSRGYKGAGHPNTNAAKAAMNMVTRTSGQEMFETDGILMTSVDTGWITDERPHFDKLRLAEAGFHAPLDLVDGAARVYDPIVRGEEGEDLYGCFLKDYAPANW
>NZ_CP029197.1|WP_015037988.1|7452919_7453090_+|hypothetical-protein
MTPELAKQEPRPAEHTDRPRRNGELGSLDVWAHAAPIRLAGYEDDLAEPHILPGID
>NZ_CP029197.1|WP_015037989.1|7453180_7454608_-|lipase-maturation-factor-family-protein
MEWFTEPDHWLSRIVFQRGLAGLYCVAFLSAALQFRALIGERGMLPVPAYVRGTRPRHTPSLFHWRYSDRLFATVAWSGAALALALVAGAADAVPLPVSMLCWLVLWALYLSIVNVGQTWYSFGWESLLLETGFLAVFLGNDEVGPPVLVLFLLRWLLFRVEFGAGLIKIRGDECWRKLTCLYHHHETQPMPGPLSWFFHHLPRPLHRVEVAANHVVQLFVPFLLFAPQPVATVAAGLMVATQLWLVLSGNFAWLNWITIVLALSVVDASPVTGEHPRPDPPLWYVALVVAVTAFVLVRSYRPVRNLLSRHQAMNRSYDPYHLVNTYGAFGTVGRVRDEIVVEGTEDPEPRPDTVWREYGFKGKPGDPRRLPRQFAPYHLRLDWLMWFAALSPGYARDWFGPFVERLLEGDRDTLRLLGHNPFPEAPPTLVRARLYRYRYTTWRELRETGAWWHRTLVREYLPPIRLREPAGKPP
>NZ_CP029197.1|WP_015037990.1|7454630_7455182_-|DUF1990-domain-containing-protein
MTRLLQDLHRPAHPRPSLSYREVGATRTPETLPEGYHHLRYEAVVGHGRAAFEAAGAAVTTFRMHRSSGARLLADAERAVPGVAVEVSAGLGPLRMAVPCAVIWTAYEQDRVGFAYGTLTGHPECGEESFTVHLEADGTVRFAVTAFSRPASWYTRLAGPVVPLLQRAYARHLGRTLRRLVRT
>NZ_CP029197.1|WP_051026227.1|7455178_7456063_-|YndJ-family-transporter
MSVLVGSVVTIGMLWVVPTGLALLDGPRPPGWEPLRRAWPLLAAPGALSLWLPRSGISTALAAVYALATLALALQAPARLFLTRSLRPGEVAVLTALLAPSVAGLALVAERASYPLLGFDLDLLALTVPHFHFAGFAAALVAGLLCRAADGPAARFAALSVPAGTLLVLIGYFVDDWAELAGAVVLTAGMTTVAVLTLRERRGTATADRLTRGLLGVSALVLFVTMLLALSWALGEATGLPHLSLTWTAATHGLGNALGFTVCALLAHRRLRADRTTPPAPAGLPARPRTELPA
>NZ_CP029197.1|WP_106433918.1|7456340_7457474_+|hypothetical-protein
MLAGCTSVWEGSRGGAEPAAAGPAQDVLLQPVAAQGPDPFTASTARGTMPVSAPQRGPDAAPEQVREVTGSTPGLYGGTRAEGSCDVDQQVSLLAADQDKTRAFAEAAGIPETNVADWLRGLTPVVLRADARVTNHGYRQGKANAFQSVLQTGTAVLVDQYGSPRVRCACGNPLRTPAASQGGVHQGDPWDGFDPDRVIVVRPTTTVVTSLVIVNAADRSWIERRTGSDGAEDRKPAVEPDCDPDACRLTGTPEAGTPDPATPDSATPDTTRPDPSAPDRRTAPDTPSRAPVPPAPVPPAPDSPLPDASGTGGTGTEPPPGDPEPYPVPDTEPYPQPDGDPHADPFAEPPGVPDGELPPEELFPAEPVPEQPETFEG
>NZ_CP029197.1|WP_015037993.1|7457523_7459608_+|SpoIIE-family-protein-phosphatase
MNAGNGGGQAAERRRAPDEQGAGARILAEFGSVFRMGGFDWNLVDGTMLMDDAALDVFDLDRAEYNDRPESLGPRVLPDEGRRLDTLVAQALKDGSAEYGAYFRIRRRDGSHQWTHTQGRVHRDDSGRPVRIVGVIRDATHELTESAARLGLDEGRRKRAGVVEGTTAALAYARTVQDVIDLLNDSHALEHFGAASLVMGLLEAGRIHLVAEGPQGAFVPGTRFTRVDEPYPMSEVIRTLRPRFIVSARDFAESFPVLWPHISGLGITAAAYLPLIAQARPIGALGLLYSDKTGFSEDERTLLVALGSSIAQSLQRAMLYEQEHDLAEGLQQAMLPRRIPEVPGAQTAVRYRSARLGRDIGGDWYDIIPLPGGRVGAVIGDVQGHDTHAAAVMGQLRIVLRAYAAEGHTPATVMARASVFLHELDTDRFATCTYAEVDLGTGVVQVVRAGHVDPLLREHDGHCRRVPVEGGLPLGLSAEFGRLDYPVTTLELDPGQTLMLYTDGLVEKPGADLDEGLQWLSALVRRGPTDLQELADHLCEVVADRGGEDDVAILLLRRLSEAAAHGAGRFQQHVAQNDPEALSSARHMIRAAVRAWGAEDHADEIELVADELMTNALMHTDGGAIVTLRILGGAERRLRVEVEDRSSALPRRREAGEAGVSGRGLLLVDRLSDVWGVESRGSGKCVWCEFTVES
>NZ_CP029197.1|WP_015037994.1|7459758_7461108_+|wax-ester/triacylglycerol-synthase-family-O-acyltransferase
MSSELLAPLDLAFWHLESTAHPLHLGALAHFGPPPADAADRTPPDLLELLARRAAAVPRLRMRVRDVLLPVGGAAWSADPDFDVRRHVHEITLPGADFRAETARLAAELMERPVARGLPPWEMYLLSGAPDGSFAVLVKLHHALADGMRAVAIGAGIFDEIAAGRRPARRPRPVTPRSWLPGPGRLLGLARDRLGDLSRAVEVGASVVRASRLDGRPTAALAAESSGTRRIATASLSLERVHRIRRGTGGTANDVLLTVVAGALRRWFAERGLPLPGADPRALVPVSRRRPGTAPGPGNSLSGYLVDLPVTEADPAARLAAVRAAMDRNKAAGPLRGAGAVALLADQLHPLAHRFGAPLASGAARLLFDLLVTQVPLPRSALSLAGAPLRALFPMAPLARGQSLAVAMSPYGGQVHIGLVADGEAVPDLDALAAALTAELDLLDPPDTP

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Crispr_ID: NZ_CP029197_23

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP029197_23

7761752-7761837

Orphan

Consensus_repeat	Method
GGTTCGGCGGGAGCGCGTACGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP029197_23

>merge|NZ_CP029197|23|7761752-7761837|CRISPRCasFinder
GGTTCGGCGGGAGCGCGTACGAGAGCGGGCGTGGGTCGGGCCAGCGGCGCACACCGGGGCGCAGGTTCGGCGGAAGCGCGTACGAG

>NZ_CP029197|23|19|7761752-7761837|CRISPRCasFinder
GGTTCGGCGGGAGCGCGTACGAG	AGCGGGCGTGGGTCGGGCCAGCGGCGCACACCGGGGCGCA
GGTTCGGCGGAAGCGCGTACGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP029197.1\|WP_041663257.1\|7775258_7776509_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
NZ_CP029197.1\|WP_015038254.1\|7753196_7753679_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP029197.1\|WP_071892526.1\|7755477_7755885_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041663255.1\|7769343_7773414_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|239155
NZ_CP029197.1\|WP_015038274.1\|7776611_7777493_-\|DUF4436-domain-containing-protein	unknown	unknown	gnl\|CDD\|379624
NZ_CP029197.1\|WP_051025983.1\|7762518_7763187_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP029197.1\|WP_015038261.1\|7757734_7759309_-\|pectate-lyase	unknown	unknown	gnl\|CDD\|226384
NZ_CP029197.1\|WP_041664541.1\|7754560_7755169_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_051026236.1\|7763423_7765091_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP029197.1\|WP_041663252.1\|7759715_7760090_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
NZ_CP029197.1\|WP_015038268.1\|7767292_7768384_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380650
NZ_CP029197.1\|WP_041663250.1\|7756091_7756859_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015038267.1\|7766407_7767193_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_CP029197.1\|WP_015038255.1\|7753926_7754286_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_015038263.1\|7760211_7761579_-\|amidohydrolase-family-protein	unknown	unknown	gnl\|CDD\|180337
NZ_CP029197.1\|WP_015038266.1\|7765118_7766411_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
NZ_CP029197.1\|WP_106433786.1\|7768523_7769315_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NZ_CP029197.1\|WP_158506280.1\|7755280_7755418_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_051025982.1\|7757076_7757706_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP029197.1\|WP_041664545.1\|7774730_7775183_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176874

Protein	Function_ID	Function_description	E-value
NZ_CP029197.1\|WP_041663257.1\|7775258_7776509_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	8.64545e-38
NZ_CP029197.1\|WP_015038254.1\|7753196_7753679_-\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.87221e-13
NZ_CP029197.1\|WP_041663255.1\|7769343_7773414_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
NZ_CP029197.1\|WP_051025983.1\|7762518_7763187_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	7.26203e-32
NZ_CP029197.1\|WP_015038261.1\|7757734_7759309_-\|pectate-lyase	gnl\|CDD\|226384	COG3866, PelB, Pectate lyase [Carbohydrate transport and metabolism].	3.01881e-51
NZ_CP029197.1\|WP_051026236.1\|7763423_7765091_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
NZ_CP029197.1\|WP_041663252.1\|7759715_7760090_+\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	1.41242e-62
NZ_CP029197.1\|WP_015038268.1\|7767292_7768384_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380650	cd19995, PBP1_ABC_xylose_binding-like, periplasmic xylose-like sugar-binding component of the ABC-type transport systems. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	1.8643e-108
NZ_CP029197.1\|WP_015038267.1\|7766407_7767193_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	6.59777e-107
NZ_CP029197.1\|WP_015038263.1\|7760211_7761579_-\|amidohydrolase-family-protein	gnl\|CDD\|180337	PRK05985, PRK05985, cytosine deaminase; Provisional.	5.64695e-159
NZ_CP029197.1\|WP_015038266.1\|7765118_7766411_-\|ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	6.84667e-97
NZ_CP029197.1\|WP_106433786.1\|7768523_7769315_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	3.71055e-14
NZ_CP029197.1\|WP_015038274.1\|7776611_7777493_-\|DUF4436-domain-containing-protein	gnl\|CDD\|379624	pfam14494, DUF4436, Domain of unknown function (DUF4436). This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.	6.1938e-86
NZ_CP029197.1\|WP_041664545.1\|7774730_7775183_+\|hypothetical-protein	gnl\|CDD\|176874	cd08865, SRPBCC_10, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	2.81782e-25

>NZ_CP029197.1|WP_015038263.1|7760211_7761579_-|amidohydrolase-family-protein
MQSTSPSPSGALSRRTMLAGAAALAGASATAAATAAPAQAATAPAAASVSAEAAHGGSGRRHRAVVFRDVRVLGAAKATDLVVVDGRVSDGPAPRGARVVDGGGRIALPSLVDAHIHPDKTTWKGSWVSRRPASGIADYVAQDVELFRSQRRPVVERAYGLMSHAVSRGTRAMRAHADVAPAYGLAGVEGVAAARERLRHALDVQIVAFPQHGVIRTPGTAALLEKAARQGLIDMIGGIDPIGFDEALDDQLDVVFGIADRHGVGVDIHLHDRGEKGMKAMRGIVDRTRALSLAGKVTVSHVFCLPGLTDRELGSIAADLGEQDIALTTVAPSDSLVLPIARLREHGVRVGLGSDGVRDSWSPFGNADMMHRAHILGWVTDVRLDEELKDCYGVATHGGADVMGLAHADFSAGAPADFVLVRGECLPQVVVDMPRRDMVVHGGVVVARDGEFLDG
>NZ_CP029197.1|WP_041663252.1|7759715_7760090_+|VOC-family-protein
MAVTFNHTIIAAKDRHESARFFRELLELPEAPSWGPFVNVQLPDGVLIQFAEPPVDIQMQHYAFLVDDELFERAYARLCDQGVEHWADPQMKRPGETNTEHGGRGVYFKDPAGHAFELITRPYL
>NZ_CP029197.1|WP_015038261.1|7757734_7759309_-|pectate-lyase
MRRPVALRLHAALATLALAAATGVVLSIPQASAAAGGATGYAGQNGGTTGGAGGQTVRATTGTAIHAALCGRASSSTPITIEVEGTINHANTAKVSGPSCNTAAGVIELKQISNVTLVGVGSGAVFDQLGIHIRESSNIIIQNVTVRNVKKSGSPLSNGGDAIGMESDVRNVWVDHSTLEASGGESEGYDGLFDMKDNTRYVTLSYSILRKSGRGGLVGSSETELSNSFITYHHNLYENIDSRAPLLRGGTAHMYNNHYLRINESGINSRAGAHAKVDNNYFEDSKDVLGTFYTDAAGYWQVSGNVYDNVTWSARGTDNNPAGPDPQSNTTVSIPYAFSLDPATCVPDVVSRTAGAGKGLQVSNGSCSPQTPTPTPTGTPTTPAPTTPTPSPTPSTPGPTQPGGTNLSIGAGSDGSSKADGTSYGNVRDGDLGTHWSPAGSTGSVSIKWGSATTVSRIVIREAAGATGVIGSWLVLNGDTGAVLTSGSGAGTISVPRTALKKITFEITGASGTPRIAEFETYAG
>NZ_CP029197.1|WP_051025982.1|7757076_7757706_+|hypothetical-protein
MTLCDPRDIGMGHVVRRYVQATYWGRPRYLEIDSALYARPEGPGRRRFVRRVLRDAAAVTDAELDALLNYEWRSRLTAAWLIGVDRRASYRERIGTLLLDSEVCFAGVGYCFALARLGTRADAELLVAYLDRYLARPELDYDQAAALGALLRLDAELGTAYADRIDAPDGPWDTWVGEQAGSDASSLAPERLRAWTDLRCDFADGWTRP
>NZ_CP029197.1|WP_041663250.1|7756091_7756859_+|hypothetical-protein
MKTRAATVWFTPVLRALTVLLGAGSFALGALAVFATQNGTGAAALIVFGGVLLLLALLGSRVESLEFGGATLRLRAAAAERFELAEESERLGDTATARQLRVEARTLMDAAGPIAADYGSVRGSMRPGATRTRALEEVVARARRLAEGQSFESAEVLRWLREGTAEERITALAMMQAKPELRNFEAALAAIAHPRTPFEQYHAMRLAMQMVDGLDGGQARRLAEAVERQRGIRFRRDSDRARLREEILQKVHGRS
>NZ_CP029197.1|WP_071892526.1|7755477_7755885_-|hypothetical-protein
MTVTDDRLDAEWLRGWCEHVDTALVELTPIPSDLTTMYWVIDEVSLPDVENGYFVHPATLVADHFREYGAVQIDGEEPALVFASDGGGHVFALAGSGRIWRSTTPSWLDQFDLAAAGLQEFFEELSRQISGSGRP
>NZ_CP029197.1|WP_158506280.1|7755280_7755418_-|hypothetical-protein
MRAEGQCAQQGQPEGSDGVALSTRLPTIAIDWVDAPERSTLSSNQ
>NZ_CP029197.1|WP_041664541.1|7754560_7755169_+|hypothetical-protein
MTGTQSTYASPADQGCPTAEIFATDNTSIITDPADPRLRTRLTRFDHEVRTLIRAHGARPAASTLLDGVFWSDDLKQATYERSREFDVNRVDRDGLHHIAGVIAKEYDQESVLTFRCLPRTSPETDAVEIEVPGVRVSGLRDALVADPEAREKLGGGSVTLDGRLLLVAPIAELPFARTFVTGLGADWNEARVRYGDREFVN
>NZ_CP029197.1|WP_015038255.1|7753926_7754286_-|hypothetical-protein
MNAHMRGTPGTTRATWPTAYLVTIAALTGCGLMIDTMALYVSIFATDSCGSTNPAPVCTPVGMLSVWALPWVGLGVAAAVSAGLGVWAWRRGRTPWVLLPVGVVLYVASLAGAWTIMTW
>NZ_CP029197.1|WP_015038254.1|7753196_7753679_-|hypothetical-protein
MDKIALTAGALYVIVLLRAGGTFAVGWLAGAGARRSRFSERISSPKFRRAERAIQRWGAPVVAVSFLTVGFQTAANFLAGSMRMPLPRYLPALFLGGAAWSLIYATAGLGVLEVLGRLFAGRTAFGVAAVAVLVLAVCAMVVYRRRRPGRPSGGPVAEES
>NZ_CP029197.1|WP_051025983.1|7762518_7763187_-|GntR-family-transcriptional-regulator
MQDERDGKRPGIVTSLSTRAREAVLQRIVDRRYAQGSRLVEREVAEELGMSRVPVREALRALVSEGLLELLPHSGVRVRRLERADVEHLYEVWEPLAVQASRLAARARAAGDTEGLAALEAALHQAESAAAADEGTREVAAHTAFHEGVVELSGNPLLVRTMDQLSWQLRLVFGLREEPAHMRAQHAEMYRHIAAGDAEAAAASTLLHVRDSRAVALRSLFG
>NZ_CP029197.1|WP_051026236.1|7763423_7765091_+|BCCT-family-transporter
MPVTADLPGRPDQHHRARTDRIVFGVTAVLTVAFVVWGATATESLEKASSDLLEGLIRNGGWAFMLAASGFVVFALWLAISRYGRITLGQESEGPEFRTVSWIAMMFSAGMGIGLMFYGVSEPLAHYGTPPPGTHPVDSAERMQTAMATTLFHWTLHPWAIYAVVGLAIAYSTFRKRRRQTISAVFVPLMGEKRAYGGPGRVIDILAIFATLFGSAASLGLGALQIGSGFEELGWMEKTGTGLLVAIIAVLTVAFVLSAVSGVEKGIQWLSNINMVLAAILAVFVFVAGPTIIVLDLLPTSLAAYFGDLPQLAGRTEATSGANIHDWLGSWTVFYWAWWISWTPFVGMFIARISRGRTIRQFVGGVILVPSTVSLIWFAVFGGTAMKLSEQGDLAGESTPEGQLFGVLQEFPIAGAMSLLVMILVGIFFVSGADAASIVMGTLSQRGAFEPTRPEVVFWGVVTGAVAAIMLLIGDGQGDALAGLQNLTILVAAPFVLVMIGMCVALMRDLRKDPLIVRGEVGVEVVELAVIAGHEQYDGDFELRIGPGTQDAGDP
>NZ_CP029197.1|WP_015038266.1|7765118_7766411_-|ABC-transporter-permease
MKRDRGRGPSPADDTASQEPAPGAVPAVDARLLVREEGVKGYVDEFRRKMRSGELGSLPVVLAVIIIWTVFGSLNSTFLSAQNLSDLSQQIVGTGMIAVGIVFVLLLGEIDLSVGSVSGLCAAIFAVLNVLNGMNEWLALLVAIAGGAAVGLIHGFFFAKVGVPAFVVTLAGNLAWNGLMLQVLGTSGTVNIPGESIVSKLYSTIYHSPAAAYVTAAVGVGLFLAASLLDAQRRRAARVPFRPVGEIVLRTVVIAALAFAAAYILNQYQGLPLALLIFLILLVLLDFVLRRTTYGRRIFAVGGNIEGARRAGISVAFVRMSVFSIAGTMAAIGGIFLAGQIQSASQTSGGGNLLMNVIAAAVIGGTSLFGGRGSVWSALLGALVIGSIQSGMNIMGVSNAVQFMITGSVLLAAVVVDSLSRRTQKAAGRA
>NZ_CP029197.1|WP_015038267.1|7766407_7767193_-|sugar-ABC-transporter-ATP-binding-protein
MSESPVLSLRGISKRFGAVQALKDFDLDVHAGEVVALVGDNGAGKSTAVKSIAGVNPPDEGVITWEGKPVSIHRPHDAQNLGIATVYQDLALCDNLDVVANLFLGRELRRFGVLDEVRMDQRARELLDTLSIRIPSVRIPVASLSGGQRQTVAIARSLIGAPKVVILDEPTAALGVEQTAEVLDLVERLREQGLGTILISHNMVDVMAVADRIAVMRLGRNNGFFDKRSTTTEEIISAITGATDSAVTRRQARKREQEEER
>NZ_CP029197.1|WP_015038268.1|7767292_7768384_-|sugar-ABC-transporter-substrate-binding-protein
MTRTLRGAIALAGATALCLGVVATSGAVQPDAGSAAQGDVRIGLLLPESKTTRYEKFDRPYIEAKIKELAPNAQIDYYNAAESATTQQQQVNTALAKGDKVLILDAVDAKSIQSSVQKARDAGVKVVAYDRLAQGPVDAYVSYDNRKVGELQGKALLDALGDKAGSGEIVMHNGSPTDPNAAEFKAGAHSVLDGKVKIGKEYDTPNWDPNNANQQMSGAISALGKDKIVGVYSANDGLAAGIATALKAAGMNVPLTGQDAQLDAIQRILLGTQTITVEKPYKPEADIAATMAVNLAEGKALPADLTPTTVTSGSGEKVPANLLTPVVVDKTNIKDTVVKDGLYTVQEICTPTYAAACKDAGLQ
>NZ_CP029197.1|WP_106433786.1|7768523_7769315_+|ankyrin-repeat-domain-containing-protein
MPRPCADAPGWGTLASVPTPLTLASRDPLALAVTEAVTTGDLDTLRGLLAAHPGLARARVVEDREGRGPGGRTLLHLATDWPGHRPRGPETVALLVAAGADPDARFTGAHRETPLHWAASNDDVPMIDALVTAGADIEADGGVIADGTPLADARAFGQWRAARRLLELGARPTFQDAATLGLLDRVEARLTATPPPSPEEITQAFWGACEGGRLPTAALLLDSGADIDWIGWNDLTPLDVARAENAEEVVAWLTARGARPRTG
>NZ_CP029197.1|WP_041663255.1|7769343_7773414_-|molybdopterin-dependent-oxidoreductase
MLLDVGLGPDGRRTVLKATGDKDHPANQGRLCTKGATTAELLAAPGRLTTALVRHERGAGLVPADTDRVLTDTARRLRAIVDEHGPDAVALYVSGQLSLEAQYLANKLAKGFIGTPWIESNSRLCMASAGTGYKLSLGADGPPGSYDDLDQADVFLVIGSNMADCHPVLFLRMMERVKAGAKLIVVDPRRTATAEKADLFLRIRPGTDLALLNGLLHLLHENGHTDAGFIAAHTEGWEAMPPFLADYPPAAVTRVTGIPEQDIRSAAEWIGTAGEWTSCWTMGLNQSTHGTWNTNALVNLHLATGAICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSALVAEDRAFTEELWDLPPGTIREDGSGQGTVDLFRRMADGEIKACWIICTNPVASVGNRSTVVEGLRAAELVITQDAFADTETNAYADVVLPAALWTETEGVLVNSERNLTLARPAVDPPGEALADWRIIARVAHAMGYEKAFSYDSAEEVFEEIRRAGNPKTGYDLSGVSYERLRTTPVQWPAASGGPARNPVRYVRGSGSDAAGSDSAGSGGPVFPTASGRAVFHARPHIDPAEMPDDDYPFVLNTGRLQHQWHTLTKTAKVAKLNKLNPEPFVELHPEDALRQGVTDGDPVEIASRRGRAVLPAVVTDRVAPGSCFAPFHWNDLFGADLSVNAVTNDAVDPLSFQPELKVCAVRLTKSPVPAATTRAPEAPEPVPVPGVVIPAGGPAPGPAAAFGLDPAPPPVLTAEERQYLVGFLAGLETGAPGVPVLPPGAPFREDHARWVNGVLAGLYSRAPQAPAVGAAATAGREVVVLWASQTGNAEDFAAAAAERLLSAGHRAALAGMDETDLTALPPAADLLLITSTFGDGDAPDNGSGFWDALAAPDTPRLDGRRYAVLALGDSSYGDFCGHGRRLDHRLDELGGVRLAPRTDCEPDYEPSALAWLDQVLAGLSETARAPEAARASAPAPVPGPTAAPARRSGPVTTPARLVGNRLLSLPGAGKEVRRFTFDTSGTGAPLSYEAGDALGVRPVNCPELVAEWLAVTGLDADSAVALPGHGPVPFGEALHRHLDITRVTPALLGFVTERTGDRDLKRLLRPDNKDGLARWTWGRQAVDVLAEHSVRATAQDWADVLGRLVPRLYSISSSPLTDPHQVSLTVSVVRYENLRGRPRKGVCSPFLADAEPGAPVPVFVRSAPHFRPPADPSTPMVMVGPGTGVAPFLGFLDERRALGHRAPNWLFFGEQHRATDFYYAEELTGFLADGTLDRLDTAFSRDQRTKVYVQDRMRERGPQLWSWLQSGAHFYVCGDAARMAKDVDRALRDIAVTHGGLDEESAGVYVKQLAADRRYVRDVY
>NZ_CP029197.1|WP_041664545.1|7774730_7775183_+|hypothetical-protein
MPVITETIDISRRPAEVFSYVTDPTHLPEWQESAVSVRKMGSEPLATGSKVAVTRRLGRREFTSTMQIIELDPPRRWHVHGIDGPVRADVRGTIEPLDDGERSRVTISLDFEGHGVGKAAVPLVVRPHARKEMPKDERTLKGILESGATA
>NZ_CP029197.1|WP_041663257.1|7775258_7776509_-|serine-hydrolase
MTHTPLTPRTRRRARSRRALLCAALLALTVQTTAVAPALADGHGGRGGSDCVRTQGRPDGAAGRVLDITRKAKSDLRLNAVQVRVTLDGREVLTDALGQSMTGVPAEPDMHFRAGSVAFAHIATTLLKLVEERRVRLDDTVERWLPDLPKADRITLRMLASNTTGLHDYVTDPAFGKELTANPFRAWTPKELVAFPLRHSFWYEPGKSWSYSHANYVYLIRALEKITGVRIDRLVREKVTGPLELRDTQNNFTPEIPRPVLHAFTSDRGLYEESTFWNPSWTTAPGAVITTHICDLARSAEAIGSGELLSPRSYRTLINPGTVGLGGGTRTCPASICLKQTEAKHFGLGVIVVNNWVVQNPSFSGYAAIQAYLPSKRLAIAVSSTKTADTPDGNTAEVVATRIAAALAPGDPLAIS
>NZ_CP029197.1|WP_015038274.1|7776611_7777493_-|DUF4436-domain-containing-protein
MSLKRRHTRAPGGPLSGALVLLAVAAAALCGLWLQFGERQDLDTRFTAGGQAPDRIDIDASVQRVDATGRELVLRVLVTPRGALAEAGGISPTEDLTLQTSSAVRGDLSFPAHGRIATVEVPVALTGGAVTDYPFDAYETEMEFGAVQGGRTVPVRMTLSNRDALFSLAVDTAEVNGAAVFSAEVARSRSVLVFAVFMMLAMWALTVAVLMGGRHLVRRRMGLTWPALGWMAATLFALAAFRNTAPGAPPIGSLLDYLAFFWAETLIAFCVTVVVVRAVRAEGPPPPRDASAP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP029197_12	12.2\|3120415\|18\|NZ_CP029197\|CRT	3120415-3120432	18	NZ_CP029197.1	5535284-5535301	1	0.944
NZ_CP029197_2	2.1\|861388\|19\|NZ_CP029197\|CRISPRCasFinder	861388-861406	19	NZ_CP029197.1	4505852-4505870	2	0.895
NZ_CP029197_5	5.2\|1682750\|22\|NZ_CP029197\|CRISPRCasFinder	1682750-1682771	22	NZ_CP029197.1	2952156-2952177	2	0.909

1. spacer 12.2|3120415|18|NZ_CP029197|CRT matches to position: 5535284-5535301, mismatch: 1, identity: 0.944

ctctcagggctctacctc	CRISPR spacer
ctctccgggctctacctc	Protospacer
***** ************

2. spacer 2.1|861388|19|NZ_CP029197|CRISPRCasFinder matches to position: 4505852-4505870, mismatch: 2, identity: 0.895

tccacccgggggcgggtgc	CRISPR spacer
tccacccggggccgggcgc	Protospacer
*********** ****.**

3. spacer 5.2|1682750|22|NZ_CP029197|CRISPRCasFinder matches to position: 2952156-2952177, mismatch: 2, identity: 0.909

cggggcgggcggtgacggcacc	CRISPR spacer
cggagcgggcggtgacggaacc	Protospacer
***.************** ***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP029197_12	12.4\|3120487\|31\|NZ_CP029197\|CRT	3120487-3120517	31	KU958700	Streptomyces phage Chymera, complete genome	29429-29459	0	1.0
NZ_CP029197_5	5.2\|1682750\|22\|NZ_CP029197\|CRISPRCasFinder	1682750-1682771	22	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	410566-410587	2	0.909
NZ_CP029197_5	5.2\|1682750\|22\|NZ_CP029197\|CRISPRCasFinder	1682750-1682771	22	NZ_CP022194	Yangia pacifica strain YSBP01 plasmid unnamed4, complete sequence	83926-83947	3	0.864
NZ_CP029197_21	21.1\|5800190\|26\|NZ_CP029197\|CRT	5800190-5800215	26	NC_016655	Rhodococcus phage REQ1, complete genome	46063-46088	3	0.885
NZ_CP029197_21	21.1\|5800190\|26\|NZ_CP029197\|CRT	5800190-5800215	26	NZ_CP020332	Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence	163428-163453	4	0.846
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013412	Burkholderia thailandensis strain 2002721643 plasmid p2002721643, complete sequence	34198-34226	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP010016	Burkholderia thailandensis 34 plasmid unnamed, complete sequence	251708-251736	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP045120	Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence	32791-32819	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP020950	Rhizobium sp. CIAT894 plasmid pRheCIAT894c, complete sequence	58761-58789	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP015007	Aminobacter aminovorans strain KCTC 2477 plasmid pAA02, complete sequence	279337-279365	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	302733-302761	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	251673-251701	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_016586	Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence	709984-710012	5	0.828
NZ_CP029197_14	14.1\|3593933\|30\|NZ_CP029197\|CRT	3593933-3593962	30	NZ_CP018077	Sulfitobacter sp. AM1-D1 plasmid unnamed1, complete sequence	168908-168937	5	0.833
NZ_CP029197_21	21.1\|5800190\|26\|NZ_CP029197\|CRT	5800190-5800215	26	NZ_LR723671	Rhizobium flavum strain YW14 plasmid 2	118884-118909	5	0.808
NZ_CP029197_21	21.1\|5800190\|26\|NZ_CP029197\|CRT	5800190-5800215	26	NZ_CP009439	Streptomyces glaucescens strain GLA.O plasmid pSglau1, complete sequence	1899-1924	5	0.808
NZ_CP029197_21	21.1\|5800190\|26\|NZ_CP029197\|CRT	5800190-5800215	26	NZ_CP030830	Neorhizobium sp. NCHU2750 plasmid pNCHU2750c, complete sequence	319994-320019	5	0.808
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP044082	Paracoccus yeei strain FDAARGOS_643 plasmid unnamed4, complete sequence	190179-190207	5	0.828
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP031080	Paracoccus yeei strain CCUG 32053 plasmid pYEE2, complete sequence	81811-81839	5	0.828
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP020440	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence	132499-132527	5	0.828
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1373622-1373650	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5463077-5463105	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1124494-1124522	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	1007884-1007912	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_010625	Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence	1705238-1705266	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP022192	Yangia pacifica strain YSBP01 plasmid unnamed2, complete sequence	55158-55186	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	1823234-1823262	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_LR134461	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 19, complete sequence	140803-140831	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP043499	Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence	1572990-1573018	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	1823232-1823260	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_AP014579	Burkholderia sp. RPE67 plasmid p1, complete sequence	26926-26954	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP014600	Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence	199381-199409	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP032324	Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence	656519-656547	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_008383	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL8, complete sequence	96625-96653	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	276810-276838	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	257152-257180	6	0.793
NZ_CP029197_12	12.4\|3120487\|31\|NZ_CP029197\|CRT	3120487-3120517	31	NZ_CP014964	Geobacter anodireducens strain SD-1 plasmid pSD, complete sequence	93706-93736	6	0.806
NZ_CP029197_14	14.1\|3593933\|30\|NZ_CP029197\|CRT	3593933-3593962	30	NZ_CP015737	Shinella sp. HZN7 plasmid pShin-01, complete sequence	252258-252287	6	0.8
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP022369	Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence	511813-511841	6	0.793
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NC_013858	Azospirillum sp. B510 plasmid pAB510d, complete sequence	582999-583027	6	0.793
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NC_010851	Streptomyces sp. FR1 plasmid pFRL1, complete sequence	7825-7853	6	0.793
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP024424	Paracoccus yeei strain TT13 plasmid pTT13-2, complete sequence	21182-21210	6	0.793
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP029830	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence	883190-883218	6	0.793
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	MH746817	Achromobacter phage vB_Ade_ART, complete genome	82591-82619	6	0.793
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP011450	Sphingomonas sanxanigenens DSM 19645 = NX02 plasmid pNXO2, complete sequence	107091-107119	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_001759	Streptomyces phaeochromogenes plasmid pJV1, complete sequence	6925-6953	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP042264	Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence	26128-26156	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP007797	Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence	160153-160181	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	264417-264445	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	401206-401234	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_011887	Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence	177134-177162	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_009959	Dinoroseobacter shibae DFL 12 = DSM 16493 plasmid pDSHI05, complete sequence	16419-16447	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_007950	Polaromonas sp. JS666 plasmid 2, complete sequence	9216-9244	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	333123-333151	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP038636	Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence	314124-314152	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_016972	Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence	43523-43551	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	326992-327020	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_004688	Mycobacterium phage Omega, complete genome	9899-9927	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	AY129338	Mycobacterium virus Omega, complete genome	9899-9927	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	JF937101	Mycobacterium virus LittleE, complete genome	8372-8400	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	KM400683	Mycobacterium phage Ariel, complete genome	7371-7399	7	0.759
NZ_CP029197_14	14.1\|3593933\|30\|NZ_CP029197\|CRT	3593933-3593962	30	NZ_CP018077	Sulfitobacter sp. AM1-D1 plasmid unnamed1, complete sequence	137872-137901	7	0.767
NZ_CP029197_14	14.1\|3593933\|30\|NZ_CP029197\|CRT	3593933-3593962	30	NZ_CP054028	Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence	1264032-1264061	7	0.767
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	1695126-1695154	7	0.759
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	KX758539	Mycobacterium phage Jaan, complete genome	34881-34909	7	0.759
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	MK279857	Mycobacterium phage IronMan, complete genome	34709-34737	7	0.759
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	EU744250	Mycobacterium virus Pukovnik, complete genome	34378-34406	7	0.759
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NC_031279	Mycobacterium phage Bactobuster, complete genome	34526-34554	7	0.759
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	20536-20564	7	0.759
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP015095	Pelagibaca abyssi strain JLT2014 plasmid pPABY4, complete sequence	104677-104705	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	385835-385863	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013536	Rhizobium phaseoli strain R650 plasmid pRphaR650d, complete sequence	306056-306084	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_017805	Deinococcus gobiensis I-0 plasmid P1, complete sequence	280468-280496	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP021033	Rhizobium sp. NXC14 plasmid pRspNXC14c, complete sequence	543002-543030	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013526	Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence	595779-595807	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013589	Rhizobium phaseoli strain N161 plasmid pRphaN161d, complete sequence	598322-598350	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013562	Rhizobium phaseoli strain N841 plasmid pRphaN841e, complete sequence	637639-637667	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013579	Rhizobium phaseoli strain N671 plasmid pRphaN671e, complete sequence	591671-591699	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013531	Rhizobium phaseoli strain R723 plasmid pRphaR723d, complete sequence	623974-624002	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013541	Rhizobium phaseoli strain R630 plasmid pRphaR630d, complete sequence	612262-612290	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013546	Rhizobium phaseoli strain R620 plasmid pRphaR620d, complete sequence	606094-606122	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013584	Rhizobium phaseoli strain N261 plasmid pRphaN261d, complete sequence	623974-624002	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NZ_CP013573	Rhizobium phaseoli strain N771 plasmid pRphaN771e, complete sequence	591671-591699	8	0.724
NZ_CP029197_5	5.1\|1682698\|29\|NZ_CP029197\|CRISPRCasFinder	1682698-1682726	29	NC_010997	Rhizobium etli CIAT 652 plasmid pC, complete sequence	597519-597547	8	0.724
NZ_CP029197_12	12.4\|3120487\|31\|NZ_CP029197\|CRT	3120487-3120517	31	KU958700	Streptomyces phage Chymera, complete genome	29330-29360	8	0.742
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_CP009112	Rhodococcus opacus strain 1CP plasmid pR1CP1, complete sequence	106408-106436	8	0.724
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_LR723678	Arsenite-oxidising bacterium NT-25 plasmid 2	30147-30175	8	0.724
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_FO082821	Rhizobium sp. NT-26 plasmid NT26_p1, complete sequence	111368-111396	8	0.724
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_FO082821	Rhizobium sp. NT-26 plasmid NT26_p1, complete sequence	314212-314240	8	0.724
NZ_CP029197_6	6.1\|1693305\|32\|NZ_CP029197\|CRISPRCasFinder	1693305-1693336	32	MT701587	Burkholderia phage Magia, complete genome	16105-16136	9	0.719
NZ_CP029197_22	22.2\|7448690\|29\|NZ_CP029197\|PILER-CR	7448690-7448718	29	NZ_LN809998	Pseudomonas aeruginosa strain MH19 plasmid pPAMH19, complete sequence	27193-27221	9	0.69

1. spacer 12.4|3120487|31|NZ_CP029197|CRT matches to KU958700 (Streptomyces phage Chymera, complete genome) position: , mismatch: 0, identity: 1.0

tcaggtagggggacagtcccccgagggggtg	CRISPR spacer
tcaggtagggggacagtcccccgagggggtg	Protospacer
*******************************

2. spacer 5.2|1682750|22|NZ_CP029197|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 2, identity: 0.909

cggggcgggcggtgacggcacc	CRISPR spacer
cggggcgggcggtgtcggcacg	Protospacer
************** ******

3. spacer 5.2|1682750|22|NZ_CP029197|CRISPRCasFinder matches to NZ_CP022194 (Yangia pacifica strain YSBP01 plasmid unnamed4, complete sequence) position: , mismatch: 3, identity: 0.864

cggggcgggcggtgacggcacc	CRISPR spacer
cggggcgggcggtgacggcctg	Protospacer
******************* .

4. spacer 21.1|5800190|26|NZ_CP029197|CRT matches to NC_016655 (Rhodococcus phage REQ1, complete genome) position: , mismatch: 3, identity: 0.885

accggaccgacggcgggcccgcccga	CRISPR spacer
accggatcgacggcgggcacgcccta	Protospacer
******.*********** ***** *

5. spacer 21.1|5800190|26|NZ_CP029197|CRT matches to NZ_CP020332 (Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence) position: , mismatch: 4, identity: 0.846

accggaccgacggcgggcccgcccga	CRISPR spacer
acctgaccgagggcgggcccgccctg	Protospacer
*** ****** ************* .

6. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013412 (Burkholderia thailandensis strain 2002721643 plasmid p2002721643, complete sequence) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcacagctcgtggcggcgggcatc	Protospacer
********* *****.*********.. *

7. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP010016 (Burkholderia thailandensis 34 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcacagctcgtggcggcgggcatc	Protospacer
********* *****.*********.. *

8. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP045120 (Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcggtgctcgcggcggcgggcctc	Protospacer
*******. ****************.  *

9. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP020950 (Rhizobium sp. CIAT894 plasmid pRheCIAT894c, complete sequence) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcgctgcttgcggcggcggtcgcc	Protospacer
*******.*****.********** .* *

10. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP015007 (Aminobacter aminovorans strain KCTC 2477 plasmid pAA02, complete sequence) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
aggcggaacttctcgcggcggcgggcgcc	Protospacer
 ***** *** **************.* *

11. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gggcggcactgctgggggcggcgggcgcc	Protospacer
 ************ * *********.* *

12. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac-	CRISPR spacer
cggcggcgctgctcgcggcgg-acgtgtcg	Protospacer
*******.************* . *** *

13. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_016586 (Azospirillum lipoferum 4B plasmid AZO_p2, complete sequence) position: , mismatch: 5, identity: 0.828

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cgatggcgctgctggcggcggcgggtgcc	Protospacer
**..***.***** ************* *

14. spacer 14.1|3593933|30|NZ_CP029197|CRT matches to NZ_CP018077 (Sulfitobacter sp. AM1-D1 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.833

gcatccgcgccggccttcctaccggccacc	CRISPR spacer
gggcccgcgccggccttcataccggcctcc	Protospacer
* ..************** ******** **

15. spacer 21.1|5800190|26|NZ_CP029197|CRT matches to NZ_LR723671 (Rhizobium flavum strain YW14 plasmid 2) position: , mismatch: 5, identity: 0.808

accggaccgacggcgggcccgcccga	CRISPR spacer
accggaccgacggcgcgcccggctcc	Protospacer
*************** ***** *.

16. spacer 21.1|5800190|26|NZ_CP029197|CRT matches to NZ_CP009439 (Streptomyces glaucescens strain GLA.O plasmid pSglau1, complete sequence) position: , mismatch: 5, identity: 0.808

accggaccgacggcgggcccgcccga	CRISPR spacer
cgcggtcctacggcgggcccgcccgg	Protospacer
  *** ** ****************.

17. spacer 21.1|5800190|26|NZ_CP029197|CRT matches to NZ_CP030830 (Neorhizobium sp. NCHU2750 plasmid pNCHU2750c, complete sequence) position: , mismatch: 5, identity: 0.808

accggaccgacggcgggcccgcccga	CRISPR spacer
accggaccgacggcgcgcccggctcc	Protospacer
*************** ***** *.

18. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP044082 (Paracoccus yeei strain FDAARGOS_643 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.828

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gatccggtcggcgcccgagccggtcaccg	Protospacer
 *.****.********.***********.

19. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP031080 (Paracoccus yeei strain CCUG 32053 plasmid pYEE2, complete sequence) position: , mismatch: 5, identity: 0.828

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gatccggtcggcgcccgagccggtcaccg	Protospacer
 *.****.********.***********.

20. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP020440 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed2, complete sequence) position: , mismatch: 5, identity: 0.828

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gatccggtcggcgcccgagccggtcaccg	Protospacer
 *.****.********.***********.

21. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcactgctcgctgcggcgagccga	Protospacer
**************** ******.*. .

22. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tcgaggcactggtcgcggccgcgggtggc	Protospacer
. * ******* ******* *******.*

23. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcactgatcgccgcggcggggctg	Protospacer
*********** **** ********

24. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcactgatcgccgcggcggggctg	Protospacer
*********** **** ********

25. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_010625 (Paraburkholderia phymatum STM815 plasmid pBPHY01, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcagcactggtcgcggcggcggaaggg	Protospacer
****.****** ************. *.

26. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP022192 (Yangia pacifica strain YSBP01 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tggcggcacggctcgaggcggcggggctc	Protospacer
.******** ***** *********   *

27. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcaccggtcgcggcggcgcctgct	Protospacer
*********.* ***********  ** .

28. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_LR134461 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 19, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
ccgcggcgctgctcggggcggcgggattc	Protospacer
* *****.******* *********   *

29. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP043499 (Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcactgcacgaggcggcgatcgag	Protospacer
************ ** *******. .**

30. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcaccggtcgcggcggcgcctgct	Protospacer
*********.* ***********  ** .

31. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_AP014579 (Burkholderia sp. RPE67 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tggcgggcctgctcgcggcggcggcgcac	Protospacer
.*****  ****************   **

32. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP014600 (Yangia sp. CCB-MM3 plasmid unnamed4, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tggcggcgctgctcgccgcggcggtcgag	Protospacer
.******.******** ******* .**

33. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP032324 (Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gggcggcgctgctggcggcggcggtttcc	Protospacer
 ******.***** ********** *  *

34. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_008383 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL8, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
ctgcggcactgcttgctgcggcgggcacc	Protospacer
* ***********.** ********.. *

35. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcaccggtcgcggcggcgcctgct	Protospacer
*********.* ***********  ** .

36. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.793

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcaccggtcgcggcggcgcctgct	Protospacer
*********.* ***********  ** .

37. spacer 12.4|3120487|31|NZ_CP029197|CRT matches to NZ_CP014964 (Geobacter anodireducens strain SD-1 plasmid pSD, complete sequence) position: , mismatch: 6, identity: 0.806

tcaggtagggggacagtcccccgagggggtg	CRISPR spacer
ttagttgagggggcagtcccccgagggggtt	Protospacer
*.** *..****.*****************

38. spacer 14.1|3593933|30|NZ_CP029197|CRT matches to NZ_CP015737 (Shinella sp. HZN7 plasmid pShin-01, complete sequence) position: , mismatch: 6, identity: 0.8

gcatccgcgccggccttcctaccg-gccacc	CRISPR spacer
tcatccgcgccggccttgccaccgtgccgg-	Protospacer
 **************** *.**** ***.

39. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP022369 (Azospirillum sp. TSH58 plasmid TSH58_p05, complete sequence) position: , mismatch: 6, identity: 0.793

cacccggccggcgcccaagccggtcacca	CRISPR spacer
ctttccgccgccgcccaagccggccacca	Protospacer
* ..* **** ************.*****

40. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NC_013858 (Azospirillum sp. B510 plasmid pAB510d, complete sequence) position: , mismatch: 6, identity: 0.793

cacccggccggcgcccaagccggtcacca	CRISPR spacer
catccggccggcgcgcaagccggtgccgc	Protospacer
**.*********** *********  *

41. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NC_010851 (Streptomyces sp. FR1 plasmid pFRL1, complete sequence) position: , mismatch: 6, identity: 0.793

cacccggccggcgcccaagccggtcacca	CRISPR spacer
cacccgcccggcgcccaagtcggccggcg	Protospacer
****** ************.***.*. *.

42. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP024424 (Paracoccus yeei strain TT13 plasmid pTT13-2, complete sequence) position: , mismatch: 6, identity: 0.793

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gatctggtcggcgcccgagccggtcaccg	Protospacer
 *.*.**.********.***********.

43. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP029830 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.793

cacccggccggcgcccaagccggtcacca	CRISPR spacer
caccgggccggcgcgcaagccggcgccct	Protospacer
**** ********* ********.  **

44. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to MH746817 (Achromobacter phage vB_Ade_ART, complete genome) position: , mismatch: 6, identity: 0.793

cacccggccggcgcccaagccggtcacca	CRISPR spacer
ctcccggctggggcccaagccggtctctt	Protospacer
* ******.** ************* *.

45. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP011450 (Sphingomonas sanxanigenens DSM 19645 = NX02 plasmid pNXO2, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggccgcactgctcgccgcggcggcgctg	Protospacer
**** *********** *******

46. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_001759 (Streptomyces phaeochromogenes plasmid pJV1, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcagtactcgcggcggcggcctgt	Protospacer
******** *.************* . ..

47. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP042264 (Litoreibacter sp. LN3S51 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tggcggccctgctagcggcggcggcggtt	Protospacer
.****** ***** **********  * .

48. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP007797 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p4, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gggcggcgctgctggcggcggcggtttcg	Protospacer
 ******.***** ********** *

49. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gcggggcagtgcccgcggcggcgggtgcg	Protospacer
  * **** ***.**************

50. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gggcggcgctgctggcggcggcggtttcg	Protospacer
 ******.***** ********** *

51. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_011887 (Methylobacterium nodulans ORS 2060 plasmid pMNOD02, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tggcggcatcgctcgcggcggcggccatc	Protospacer
.*******..************** .. *

52. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_009959 (Dinoroseobacter shibae DFL 12 = DSM 16493 plasmid pDSHI05, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tcgcggcactgctggcggtggcgggcgtg	Protospacer
. *********** ****.******.*

53. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_007950 (Polaromonas sp. JS666 plasmid 2, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
aggcggcgctgctggcggcggcggcccgc	Protospacer
 ******.***** ********** . .*

54. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gggcggccctgctggcggcggcggcggcg	Protospacer
 ****** ***** **********  *

55. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP038636 (Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
aggcggcactgcttgcggcggtggagagc	Protospacer
 ************.*******.**. ..*

56. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_016972 (Streptomyces hygroscopicus subsp. jinggangensis 5008 plasmid pSHJG2, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gggccgcgctgctcgcggcggcggccctc	Protospacer
 *** **.**************** .  *

57. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
gggcggcgctgctggcggcggcggtttcg	Protospacer
 ******.***** ********** *

58. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_004688 (Mycobacterium phage Omega, complete genome) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tgcgcgcactgcgcgcggcggcggttgaa	Protospacer
.*   ******* *********** ***

59. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to AY129338 (Mycobacterium virus Omega, complete genome) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tgcgcgcactgcgcgcggcggcggttgaa	Protospacer
.*   ******* *********** ***

60. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to JF937101 (Mycobacterium virus LittleE, complete genome) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tgcgcgcactgcgcgcggcggcggttgaa	Protospacer
.*   ******* *********** ***

61. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to KM400683 (Mycobacterium phage Ariel, complete genome) position: , mismatch: 7, identity: 0.759

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
tgcgcgcactgcgcgcggcggcggttgaa	Protospacer
.*   ******* *********** ***

62. spacer 14.1|3593933|30|NZ_CP029197|CRT matches to NZ_CP018077 (Sulfitobacter sp. AM1-D1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

gcatccgcgccggccttcctaccggccacc	CRISPR spacer
ggcagcgcgccggccttcatcccggccagc	Protospacer
*    ************* * ******* *

63. spacer 14.1|3593933|30|NZ_CP029197|CRT matches to NZ_CP054028 (Rhizobium sp. JKLM19E plasmid pPR19E01, complete sequence) position: , mismatch: 7, identity: 0.767

gcatccgcgccggccttcctaccggccacc	CRISPR spacer
acgaccgcgccggcctttctaccagccgct	Protospacer
.*. *************.*****.***.*.

64. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

cacccggccggcgcccaagccggtcacca	CRISPR spacer
ggcggtgccggtgcccacgccggtcacca	Protospacer
 .*   *****.***** ***********

65. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to KX758539 (Mycobacterium phage Jaan, complete genome) position: , mismatch: 7, identity: 0.759

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gtcccagccggcccccaagccggtcgtcg	Protospacer
  ***.****** ************..*.

66. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to MK279857 (Mycobacterium phage IronMan, complete genome) position: , mismatch: 7, identity: 0.759

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gtcccagccggcccccaagccggtcgtcg	Protospacer
  ***.****** ************..*.

67. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to EU744250 (Mycobacterium virus Pukovnik, complete genome) position: , mismatch: 7, identity: 0.759

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gtcccagccggcccccaagccggtcgtcg	Protospacer
  ***.****** ************..*.

68. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NC_031279 (Mycobacterium phage Bactobuster, complete genome) position: , mismatch: 7, identity: 0.759

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gtcccagccggcccccaagccggtcgtcg	Protospacer
  ***.****** ************..*.

69. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 7, identity: 0.759

cacccggccggcgcccaagccggtcacca	CRISPR spacer
atggccgccggcgccgaagcgggtcacca	Protospacer
    * ********* **** ********

70. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP015095 (Pelagibaca abyssi strain JLT2014 plasmid pPABY4, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
ccctttgtctgcgcgcggcggcgggtgac	Protospacer
*  .    **** ****************

71. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
cggcggcgctgctcgcggcggtcacgctc	Protospacer
*******.*************. .    *

72. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013536 (Rhizobium phaseoli strain R650 plasmid pRphaR650d, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

73. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_017805 (Deinococcus gobiensis I-0 plasmid P1, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
aggcggcgctgctcgcggcggcccagacc	Protospacer
 ******.**************  . . *

74. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP021033 (Rhizobium sp. NXC14 plasmid pRspNXC14c, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

75. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013526 (Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

76. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013589 (Rhizobium phaseoli strain N161 plasmid pRphaN161d, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

77. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013562 (Rhizobium phaseoli strain N841 plasmid pRphaN841e, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

78. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013579 (Rhizobium phaseoli strain N671 plasmid pRphaN671e, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

79. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013531 (Rhizobium phaseoli strain R723 plasmid pRphaR723d, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

80. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013541 (Rhizobium phaseoli strain R630 plasmid pRphaR630d, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

81. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013546 (Rhizobium phaseoli strain R620 plasmid pRphaR620d, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

82. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013584 (Rhizobium phaseoli strain N261 plasmid pRphaN261d, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

83. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NZ_CP013573 (Rhizobium phaseoli strain N771 plasmid pRphaN771e, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

84. spacer 5.1|1682698|29|NZ_CP029197|CRISPRCasFinder matches to NC_010997 (Rhizobium etli CIAT 652 plasmid pC, complete sequence) position: , mismatch: 8, identity: 0.724

cggcggcactgctcgcggcggcgggtgac	CRISPR spacer
atccggcaccgctcgcggcggcggctctg	Protospacer
   ******.************** *

85. spacer 12.4|3120487|31|NZ_CP029197|CRT matches to KU958700 (Streptomyces phage Chymera, complete genome) position: , mismatch: 8, identity: 0.742

tcaggtagggggacagtcccccgagggggtg	CRISPR spacer
agaggtaggggcactgtcccccgaggtatcg	Protospacer
  ********* ** *********** . .*

86. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_CP009112 (Rhodococcus opacus strain 1CP plasmid pR1CP1, complete sequence) position: , mismatch: 8, identity: 0.724

cacccggccggcgcccaagccggtcacca	CRISPR spacer
gacccggccggcgccgaagccgaaggtcg	Protospacer
 ************** ******.  ..*.

87. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_LR723678 (Arsenite-oxidising bacterium NT-25 plasmid 2) position: , mismatch: 8, identity: 0.724

cacccggccggcgcccaagccggtcacca	CRISPR spacer
ttcccggccggcgcccgagccgggagcgc	Protospacer
. **************.******  .*

88. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_FO082821 (Rhizobium sp. NT-26 plasmid NT26_p1, complete sequence) position: , mismatch: 8, identity: 0.724

cacccggccggcgcccaagccggtcacca	CRISPR spacer
ttcccggccggcgcccgagccgggagcgc	Protospacer
. **************.******  .*

89. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_FO082821 (Rhizobium sp. NT-26 plasmid NT26_p1, complete sequence) position: , mismatch: 8, identity: 0.724

cacccggccggcgcccaagccggtcacca	CRISPR spacer
ttcccggccggcgcccgagccgggagcgc	Protospacer
. **************.******  .*

90. spacer 6.1|1693305|32|NZ_CP029197|CRISPRCasFinder matches to MT701587 (Burkholderia phage Magia, complete genome) position: , mismatch: 9, identity: 0.719

cccgccgcg------cggctgctagggcgtgacggtcg	CRISPR spacer
------gtgggacatcggctgctggggcgagacggtcg	Protospacer
      *.*      ********.***** ********

91. spacer 22.2|7448690|29|NZ_CP029197|PILER-CR matches to NZ_LN809998 (Pseudomonas aeruginosa strain MH19 plasmid pPAMH19, complete sequence) position: , mismatch: 9, identity: 0.69

cacccggccggcgcccaagccggtcacca	CRISPR spacer
cacccggccggcgcgcaagccttcggtgg	Protospacer
************** ******  . .. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1565627 : 1572819

Bacillus_virus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015032601.1\|1565627_1566320_+	nucleotidyltransferase	G3M9V9	Bacillus_virus	3.6e-15	27.9
WP_015032602.1\|1566411_1567185_-	nucleotidyltransferase	K4K696	Caulobacter_phage	1.4e-07	37.1
WP_015032603.1\|1567188_1568211_-	ADP-ribosylglycohydrolase family protein	NA	NA	NA	NA
WP_015032604.1\|1568207_1568975_-	NUDIX hydrolase	A0A0E3JJF3	Streptomyces_phage	3.7e-21	46.7
WP_015032605.1\|1568971_1570051_-	AAA family ATPase	A0A2K8HHU5	Bacteriophage	8.9e-29	31.1
WP_041662201.1\|1570047_1570701_-	nicotinamide mononucleotide transporter	A0A0F6YPU8	Sinorhizobium_phage	4.9e-14	31.2
WP_041662202.1\|1570846_1572205_-	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_015032608.1\|1572204_1572819_-	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	3.4e-09	29.4

DBSCAN-SWA_2

2315520 : 2323451

Streptomyces_phage(33.33%)

capsid,portal,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015033339.1\|2315520_2316387_+	NAD-dependent epimerase/dehydratase family protein	M1NML0	Moumouvirus	9.1e-08	27.6
WP_015033340.1\|2316404_2316602_+	hypothetical protein	NA	NA	NA	NA
WP_015033342.1\|2316891_2317167_+	hypothetical protein	NA	NA	NA	NA
WP_106433832.1\|2317495_2317942_+	hypothetical protein	A0A2H5BLH4	Streptomyces_phage	3.2e-25	47.9
WP_015033345.1\|2317934_2319665_+\|terminase	phage terminase large subunit protein	K4NXE0	Streptomyces_phage	1.2e-136	49.8
WP_015033346.1\|2319661_2321089_+\|portal	phage portal protein	A0A2H4JAT8	uncultured_Caudovirales_phage	1.6e-73	41.5
WP_015033347.1\|2321069_2321840_+	hypothetical protein	A0A2P1CI11	Mycobacterium_phage	6.0e-11	27.2
WP_015033348.1\|2321894_2322482_+	hypothetical protein	NA	NA	NA	NA
WP_015033349.1\|2322494_2323451_+\|capsid	phage major capsid protein	V5R986	Arthrobacter_phage	4.9e-39	36.1

DBSCAN-SWA_3

2328136 : 2339147

Streptomyces_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015033359.1\|2328136_2332480_+	hypothetical protein	A0A2H5BLS1	Streptomyces_phage	3.2e-125	52.6
WP_015033360.1\|2332483_2334715_+	hypothetical protein	Q6VY41	Streptomyces_phage	1.9e-198	50.8
WP_015033361.1\|2334716_2335808_+	DUF5047 domain-containing protein	Q6VY40	Streptomyces_phage	2.3e-117	60.9
WP_041663828.1\|2336011_2336488_+	hypothetical protein	Q6VY39	Streptomyces_phage	3.3e-60	75.7
WP_015033363.1\|2336500_2337094_+	hypothetical protein	Q6VY38	Streptomyces_phage	1.8e-63	61.9
WP_015033364.1\|2337107_2337359_+	hypothetical protein	NA	NA	NA	NA
WP_015033366.1\|2338370_2338724_+	hypothetical protein	NA	NA	NA	NA
WP_015033367.1\|2338724_2339147_+	hypothetical protein	Q6VY36	Streptomyces_phage	1.5e-11	38.3

DBSCAN-SWA_4

3115566 : 3151340

Streptomyces_phage(98.11%)

portal,head,tail,terminase,integrase,capsid

attL 3115366:3115390|attR 3150108:3150132

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3115366:3115390	attL	NA	NA	NA	NA
WP_110014473.1\|3115566_3115977_-	hypothetical protein	A0A142K659	Streptomyces_phage	5.9e-66	100.0
WP_015034041.1\|3116171_3116390_+	helix-turn-helix domain-containing protein	A0A142K660	Streptomyces_phage	8.6e-32	100.0
WP_015034042.1\|3116386_3116629_+	hypothetical protein	A0A142K661	Streptomyces_phage	2.6e-37	100.0
WP_015034043.1\|3116705_3116930_+	hypothetical protein	A0A142K662	Streptomyces_phage	9.1e-37	100.0
WP_015034044.1\|3117036_3117528_+	hypothetical protein	A0A142K664	Streptomyces_phage	4.1e-90	100.0
WP_015034045.1\|3117527_3117902_+	hypothetical protein	A0A142K665	Streptomyces_phage	1.3e-75	100.0
WP_015034046.1\|3117898_3118348_+	hypothetical protein	A0A142K666	Streptomyces_phage	5.6e-78	100.0
WP_145953706.1\|3118344_3118935_+	hypothetical protein	A0A142K667	Streptomyces_phage	2.7e-112	100.0
WP_015034048.1\|3118927_3119212_+	hypothetical protein	A0A142K668	Streptomyces_phage	6.5e-48	100.0
WP_041662475.1\|3119208_3119415_+	hypothetical protein	A0A142K669	Streptomyces_phage	7.6e-38	100.0
WP_015034049.1\|3119418_3119826_+	MarR family transcriptional regulator	A0A142K670	Streptomyces_phage	6.2e-76	100.0
WP_041662476.1\|3119896_3120979_+	hypothetical protein	A0A142K671	Streptomyces_phage	3.1e-170	100.0
WP_015034051.1\|3121016_3121328_+	hypothetical protein	A0A142K672	Streptomyces_phage	5.7e-53	100.0
WP_015034052.1\|3121324_3121981_+	helix-turn-helix transcriptional regulator	A0A142K673	Streptomyces_phage	1.1e-111	99.5
WP_167537156.1\|3122011_3122266_+	WhiB family transcriptional regulator	A0A142K674	Streptomyces_phage	1.3e-44	100.0
WP_051025877.1\|3122301_3123294_+	hypothetical protein	A0A142K675	Streptomyces_phage	1.4e-177	100.0
WP_015034055.1\|3123290_3123983_+	hypothetical protein	A0A142K676	Streptomyces_phage	5.9e-135	100.0
WP_015034056.1\|3123979_3124507_+	HTH domain-containing protein	A0A142K677	Streptomyces_phage	5.8e-90	100.0
WP_015034057.1\|3124622_3124883_+	hypothetical protein	A0A142K678	Streptomyces_phage	2.3e-39	100.0
WP_145953707.1\|3124977_3125160_+	hypothetical protein	A0A142K679	Streptomyces_phage	2.2e-28	100.0
WP_015034059.1\|3125156_3125363_+	hypothetical protein	A0A142K680	Streptomyces_phage	3.5e-35	100.0
WP_078508881.1\|3125548_3125731_+	hypothetical protein	A0A142K681	Streptomyces_phage	3.9e-30	98.3
WP_015034061.1\|3125879_3126362_+\|terminase	phage terminase small subunit P27 family	A0A142K627	Streptomyces_phage	3.1e-90	100.0
WP_069202201.1\|3126453_3128190_+\|terminase	terminase large subunit	A0A142K628	Streptomyces_phage	0.0e+00	100.0
WP_015034063.1\|3128207_3128390_+	hypothetical protein	A0A142K629	Streptomyces_phage	1.3e-09	100.0
WP_015034064.1\|3128392_3130405_+\|portal	phage portal protein	A0A142K630	Streptomyces_phage	0.0e+00	100.0
WP_041662478.1\|3130591_3131293_+	hypothetical protein	A0A142K631	Streptomyces_phage	1.3e-129	100.0
WP_015034066.1\|3131349_3132579_+\|capsid	phage major capsid protein	A0A142K632	Streptomyces_phage	1.3e-230	100.0
WP_015034067.1\|3132629_3133007_+	hypothetical protein	A0A142K633	Streptomyces_phage	1.3e-59	100.0
WP_015034068.1\|3133092_3133452_+	hypothetical protein	A0A142K634	Streptomyces_phage	1.4e-42	100.0
WP_015034069.1\|3133451_3134036_+	hypothetical protein	A0A142K635	Streptomyces_phage	5.8e-107	100.0
WP_015034070.1\|3134032_3134365_+\|head,tail	head-tail adaptor protein	A0A142K636	Streptomyces_phage	9.0e-57	100.0
WP_015034071.1\|3134366_3134741_+	hypothetical protein	A0A142K637	Streptomyces_phage	2.3e-61	100.0
WP_041663926.1\|3134764_3135163_+	DUF3168 domain-containing protein	A0A142K638	Streptomyces_phage	6.3e-73	100.0
WP_015034073.1\|3135229_3135568_+	hypothetical protein	A0A142K639	Streptomyces_phage	1.0e-47	100.0
WP_015034074.1\|3135569_3136001_+	hypothetical protein	A0A142K640	Streptomyces_phage	2.7e-77	100.0
WP_015034075.1\|3136017_3136431_+	hypothetical protein	A0A142K641	Streptomyces_phage	2.5e-72	100.0
WP_015034076.1\|3136451_3136754_+	hypothetical protein	A0A142K642	Streptomyces_phage	2.3e-51	100.0
WP_015034077.1\|3136750_3138787_+	hypothetical protein	A0A142K643	Streptomyces_phage	4.7e-273	100.0
WP_015034078.1\|3138789_3141558_+	hypothetical protein	A0A142K644	Streptomyces_phage	0.0e+00	100.0
WP_015034079.1\|3141569_3142007_+	hypothetical protein	A0A142K645	Streptomyces_phage	2.1e-77	100.0
WP_015034080.1\|3142077_3142953_+	N-acetylmuramoyl-L-alanine amidase	A0A142K646	Streptomyces_phage	4.5e-172	100.0
WP_015034081.1\|3142965_3143193_+	hypothetical protein	A0A142K647	Streptomyces_phage	1.2e-33	100.0
WP_051025879.1\|3143156_3143435_+	hypothetical protein	A0A142K648	Streptomyces_phage	2.3e-37	98.8
WP_015034083.1\|3143479_3143692_-	hypothetical protein	NA	NA	NA	NA
WP_015034085.1\|3143953_3145177_+	helix-turn-helix domain-containing protein	A0A142K650	Streptomyces_phage	1.2e-231	100.0
WP_015034086.1\|3145295_3145739_+	hypothetical protein	A0A142K651	Streptomyces_phage	5.2e-76	100.0
WP_015034087.1\|3145877_3146357_+	hypothetical protein	A0A142K652	Streptomyces_phage	2.2e-88	100.0
WP_078508664.1\|3146618_3146777_-	helix-turn-helix transcriptional regulator	A0A142K654	Streptomyces_phage	2.4e-20	100.0
WP_015034090.1\|3146971_3147922_-	putative regulatory protein	A0A142K655	Streptomyces_phage	6.6e-177	100.0
WP_158506259.1\|3148085_3148247_+	hypothetical protein	A0A142K656	Streptomyces_phage	3.3e-20	98.1
WP_041662481.1\|3148374_3148641_+	hypothetical protein	A0A142K657	Streptomyces_phage	2.6e-38	100.0
WP_015034093.1\|3148723_3150010_-\|integrase	site-specific integrase	A0A142K658	Streptomyces_phage	1.7e-252	100.0
WP_015034094.1\|3150569_3151340_+	ABC transporter ATP-binding protein	W5SAS9	Pithovirus	7.3e-17	31.1
3150108:3150132	attR	NA	NA	NA	NA

DBSCAN-SWA_5

4698281 : 4716605

Streptomyces_phage(72.73%)

tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_041662771.1\|4698281_4701764_+	DNA-directed RNA polymerase subunit beta	G8DH04	Emiliania_huxleyi_virus	2.0e-29	22.2
WP_015035542.1\|4701871_4705771_+	DNA-directed RNA polymerase subunit beta'	A0A2I7QNZ7	Vibrio_phage	6.5e-53	27.4
WP_015035543.1\|4705836_4706100_-	hypothetical protein	A0A1J0MCA5	Streptomyces_phage	2.8e-29	78.2
WP_015035544.1\|4706086_4706332_-	hypothetical protein	A0A142K647	Streptomyces_phage	1.1e-19	69.3
WP_015035545.1\|4706355_4707267_-	N-acetylmuramoyl-L-alanine amidase	A0A2P1N078	Streptomyces_phage	1.1e-101	59.8
WP_015035546.1\|4707344_4707755_-	hypothetical protein	NA	NA	NA	NA
WP_015035547.1\|4707813_4708383_-	hypothetical protein	NA	NA	NA	NA
WP_015035548.1\|4708382_4709513_-	hypothetical protein	A0A2H5BLE2	Streptomyces_phage	2.7e-84	45.3
WP_015035549.1\|4709524_4710670_-	hypothetical protein	A0A1J0MCI7	Streptomyces_phage	6.3e-57	38.5
WP_015035550.1\|4710701_4711895_-	hypothetical protein	A0A1V0E646	Streptomyces_phage	1.4e-43	44.1
WP_015035551.1\|4711932_4713126_-	hypothetical protein	A0A2H5BLD9	Streptomyces_phage	3.2e-43	48.2
WP_015035552.1\|4713175_4714108_-	hypothetical protein	A0A1J0MCE5	Streptomyces_phage	7.7e-53	43.1
WP_015035553.1\|4714155_4715403_-	hypothetical protein	NA	NA	NA	NA
WP_015035554.1\|4715399_4716605_-\|tail	phage tail protein	Q8SBP1	Clostridium_phage	1.1e-08	45.1

DBSCAN-SWA_6

6320495 : 6373132

uncultured_Caudovirales_phage(25.0%)

tail,protease,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_015036990.1\|6320495_6323660_+\|protease	serine protease	NA	NA	NA	NA
WP_015036991.1\|6323694_6325224_-	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	A0A2H4JC96	uncultured_Caudovirales_phage	8.0e-07	37.3
WP_150162267.1\|6325275_6325632_-	extradiol dioxygenase	NA	NA	NA	NA
WP_041663018.1\|6325905_6328623_+	aconitate hydratase AcnA	NA	NA	NA	NA
WP_015036994.1\|6328739_6329555_-	VCBS repeat-containing protein	NA	NA	NA	NA
WP_015036995.1\|6330180_6331626_+	carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein	NA	NA	NA	NA
WP_015036996.1\|6331727_6332657_+	sugar ABC transporter permease	NA	NA	NA	NA
WP_015036997.1\|6332656_6333595_+	carbohydrate ABC transporter permease	NA	NA	NA	NA
WP_015036998.1\|6333820_6335041_+	ROK family transcriptional regulator	NA	NA	NA	NA
WP_015036999.1\|6335162_6336227_+	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_078508918.1\|6336524_6337289_+	sugar ABC transporter ATP-binding protein	A0A076FI99	Aureococcus_anophage	2.3e-10	30.7
WP_015037001.1\|6337285_6338605_+	ABC transporter permease	NA	NA	NA	NA
WP_015037002.1\|6338860_6340819_+	1-deoxy-D-xylulose-5-phosphate synthase	NA	NA	NA	NA
WP_015037003.1\|6340941_6342456_+	amino acid permease	NA	NA	NA	NA
WP_015037004.1\|6342564_6343659_+	hypothetical protein	NA	NA	NA	NA
WP_015037005.1\|6343729_6345868_-	3-hydroxyacyl-CoA dehydrogenase	NA	NA	NA	NA
WP_041663019.1\|6345864_6347079_-	acetyl-CoA C-acyltransferase	NA	NA	NA	NA
WP_015037007.1\|6347419_6348703_-	ribonuclease D	NA	NA	NA	NA
WP_015037008.1\|6348785_6349451_-	response regulator transcription factor	NA	NA	NA	NA
WP_041663020.1\|6349689_6350391_-	DUF3000 domain-containing protein	NA	NA	NA	NA
WP_015037010.1\|6350482_6351559_+	uroporphyrinogen decarboxylase	NA	NA	NA	NA
WP_015037011.1\|6351653_6353027_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_051025953.1\|6353036_6354050_-	DUF4349 domain-containing protein	NA	NA	NA	NA
WP_015037013.1\|6354185_6355685_+	protoporphyrinogen oxidase	NA	NA	NA	NA
WP_041663021.1\|6355702_6356416_+	chlorite dismutase family protein	NA	NA	NA	NA
WP_041664326.1\|6356610_6357657_-	TIGR04222 domain-containing membrane protein	NA	NA	NA	NA
WP_015037016.1\|6357664_6359065_-	DUF692 domain-containing protein	NA	NA	NA	NA
WP_015037018.1\|6360907_6361486_-\|tail	phage tail protein	NA	NA	NA	NA
WP_015037019.1\|6361482_6363444_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_015037020.1\|6363443_6363866_-	GPW/gp25 family protein	Q6QIA0	Burkholderia_phage	1.9e-06	44.9
WP_015037021.1\|6363865_6364183_-	hypothetical protein	NA	NA	NA	NA
WP_015037022.1\|6364194_6366012_-	VgrG-related protein	NA	NA	NA	NA
WP_015037023.1\|6366008_6366731_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_015037024.1\|6366837_6367263_-\|tail	phage tail protein	NA	NA	NA	NA
WP_071892231.1\|6367332_6370452_-	hypothetical protein	NA	NA	NA	NA
WP_015037026.1\|6370456_6370615_-	hypothetical protein	NA	NA	NA	NA
WP_015037027.1\|6370611_6371106_-	hypothetical protein	NA	NA	NA	NA
WP_015037028.1\|6371102_6371543_-\|tail	phage tail protein	NA	NA	NA	NA
WP_015037029.1\|6371578_6373132_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	4.7e-71	33.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP029197

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection