CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP044089	Bordetella bronchiseptica strain FDAARGOS_634 chromosome, complete genome	13 crisprs	csa3,DEDDh,cas3,DinG	3	3	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP044089_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_1

1222907-1223044

Orphan

Consensus_repeat	Method
GTGTTTCACGTGAAACAAC	PILER-CR

2 spacers

The CRISPR arrays of NZ_CP044089_1

>merge|NZ_CP044089|1|1222907-1223044|PILER-CR
GTGTTTCACGTGAAACATGCAGCGCCTGTTCCGACCCTCAATAGTGCGATTACGTGTTCCACGTGAAACAACACACCTTGATTCGGCATTGAGGCCGATTCACTCAACCCGCCAGCGCGATGTTTCACGTGAAACAAC

>NZ_CP044089|1|1|1222907-1223044|PILER-CR
GTGTTTCACGTGAAACATG	CAGCGCCTGTTCCGACCCTCAATAGTGCGATTAC
GTGTTCCACGTGAAACAAC	ACACCTTGATTCGGCATTGAGGCCGATTCACTCAACCCGCCAGCGCG
ATGTTTCACGTGAAACAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_004565926.1\|1234964_1236551_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NZ_CP044089.1\|WP_003818288.1\|1216591_1217593_-\|asparaginase	unknown	unknown	gnl\|CDD\|199208
NZ_CP044089.1\|WP_003818281.1\|1225132_1226326_+\|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl\|CDD\|181642
NZ_CP044089.1\|WP_003806886.1\|1213148_1213580_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_CP044089.1\|WP_003806884.1\|1214186_1214567_-\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|235587
NZ_CP044089.1\|WP_003806883.1\|1214805_1215996_-\|elongation-factor-Tu	unknown	unknown	gnl\|CDD\|234596
NZ_CP044089.1\|WP_003818277.1\|1229588_1231004_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|182388
NZ_CP044089.1\|WP_003806885.1\|1213643_1214177_-\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_CP044089.1\|WP_003818282.1\|1220842_1222762_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	unknown	unknown	gnl\|CDD\|235362
NZ_CP044089.1\|WP_003818284.1\|1220153_1220846_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	unknown	unknown	gnl\|CDD\|234637
NZ_CP044089.1\|WP_003818286.1\|1218546_1219353_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP044089.1\|WP_003816057.1\|1231038_1231719_-\|response-regulator	unknown	unknown	gnl\|CDD\|185376
NZ_CP044089.1\|WP_003816062.1\|1228463_1229468_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|225722
NZ_CP044089.1\|WP_003806879.1\|1219359_1220157_-\|ParA-family-protein	unknown	unknown	gnl\|CDD\|379293
NZ_CP044089.1\|WP_003806881.1\|1217585_1218503_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|275105
NZ_CP044089.1\|WP_003816065.1\|1226401_1227925_-\|tripartite-tricarboxylate-transporter-TctA	unknown	unknown	gnl\|CDD\|225870
NZ_CP044089.1\|WP_003816068.1\|1224553_1224760_-\|cold-shock-protein	unknown	unknown	gnl\|CDD\|224197
NZ_CP044089.1\|WP_003818275.1\|1232276_1233551_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
NZ_CP044089.1\|WP_150348896.1\|1233495_1234848_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
NZ_CP044089.1\|WP_003818279.1\|1227921_1228359_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl\|CDD\|377815

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_004565926.1\|1234964_1236551_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP044089.1\|WP_003818288.1\|1216591_1217593_-\|asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	2.79601e-128
NZ_CP044089.1\|WP_003818281.1\|1225132_1226326_+\|pyridoxal-phosphate-dependent-aminotransferase	gnl\|CDD\|181642	PRK09082, PRK09082, methionine aminotransferase; Validated.	0
NZ_CP044089.1\|WP_003806886.1\|1213148_1213580_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	3.95413e-93
NZ_CP044089.1\|WP_003806884.1\|1214186_1214567_-\|preprotein-translocase-subunit-SecE	gnl\|CDD\|235587	PRK05740, secE, preprotein translocase subunit SecE; Reviewed.	2.94869e-31
NZ_CP044089.1\|WP_003806883.1\|1214805_1215996_-\|elongation-factor-Tu	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
NZ_CP044089.1\|WP_003818277.1\|1229588_1231004_-\|sensor-histidine-kinase	gnl\|CDD\|182388	PRK10337, PRK10337, sensor protein QseC; Provisional.	1.64826e-52
NZ_CP044089.1\|WP_003806885.1\|1213643_1214177_-\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	1.04532e-103
NZ_CP044089.1\|WP_003818282.1\|1220842_1222762_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
NZ_CP044089.1\|WP_003818284.1\|1220153_1220846_-\|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	2.38528e-75
NZ_CP044089.1\|WP_003818286.1\|1218546_1219353_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.1004e-10
NZ_CP044089.1\|WP_003816057.1\|1231038_1231719_-\|response-regulator	gnl\|CDD\|185376	PRK15479, PRK15479, transcriptional regulator TctD.	2.3231e-75
NZ_CP044089.1\|WP_003816062.1\|1228463_1229468_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	2.77666e-94
NZ_CP044089.1\|WP_003806879.1\|1219359_1220157_-\|ParA-family-protein	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.37402e-85
NZ_CP044089.1\|WP_003806881.1\|1217585_1218503_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	3.93163e-80
NZ_CP044089.1\|WP_003816065.1\|1226401_1227925_-\|tripartite-tricarboxylate-transporter-TctA	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP044089.1\|WP_003816068.1\|1224553_1224760_-\|cold-shock-protein	gnl\|CDD\|224197	COG1278, CspC, Cold shock proteins [Transcription].	1.00961e-35
NZ_CP044089.1\|WP_003818275.1\|1232276_1233551_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.79182e-33
NZ_CP044089.1\|WP_150348896.1\|1233495_1234848_-\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NZ_CP044089.1\|WP_003818279.1\|1227921_1228359_-\|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	5.11272e-07

>NZ_CP044089.1|WP_003818282.1|1220842_1222762_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-enzyme-MnmG
MDFPREFDVIVVGGGHAGTEAALAAARAGAQTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAIATDEAGIQFRILNSSKGPAVRATRAQADRVLYRNAIRARLENQPNLWLFQQAVDDLMVQGDQVVGAVTQIGLRFRARTVVLTAGTFLNGLIHVGLQNYSGGRAGDPPANSLGQRLKELQLPQGRLKTGTPPRIDGRSINYSVLEEQPGDLDPVPVFSFLGKASMHPRQLPCWITHTNARTHEIIRGGLDRSPMYSGVIEGVGPRYCPSIEDKIHRFADKASHQVFLEPEGLNTHEIYPNGVSTSLPFDVQYELIHSLPGLENAHILRPGYAIEYDYFDPRALKSTLETKAISGLFFAGQINGTTGYEEAAAQGLLAGANAALQAQGKEPWVPRRDEAYLGVLVDDLVTRGVTEPYRMFTSRAEYRLSLREDNADLRLTEIGRRLGLVDDVRWDAFSRKRDAVAQEVERLKSTWVNPRVLPAHAAEALLGKAIEREYSLSDLLKRPNVSYEALMQARTDEGELLAGPGVLEDEVLAEQVETQVKYAGYIARQQDEVQKHLSHEQQPIPADIDYDAVTSLSFEVRQKLKTHRPETIGQAARVSGVTPAAISLLLIHLKRLHYGSRKQAA
>NZ_CP044089.1|WP_003818284.1|1220153_1220846_-|16S-rRNA-(guanine(527)-N(7))-methyltransferase-RsmG
MSAVPDIPGGPAQRLAQACDALRLPADAGQQQKLLRYIEQMQRWNRTYNLTAIRDPGQMLVQHLFDSLSVVAPLERGLPAAESGARVKLFDVGSGGGLPGVVLAIMRAHWDVTCVDAVEKKTAFVRQMAGALGLPNLQAAHTRIEQLEPAQCDVVISRAFASLQDFAKLAGRHVREGGTLVAMKGKVPDDEIQALQQHGHWTVERIEPLVVPALDAQRCLIWMRRSQGNI
>NZ_CP044089.1|WP_003806879.1|1219359_1220157_-|ParA-family-protein
MKNIPPSKSARVFCIANQKGGVGKTTTAINLAAGLATHKQRVLLVDLDPQGNATMGSGIDKSTLESNLYQVLIGEAGIEQTRVRSESGGYDVLPANRELSGAEIDLVQMDERERQLKAAIDKIAGEYDFVLIDCPPTLSLLTLNGLAAAHGVIIPMQCEYFALEGLSDLVNTIKRVHRNINNELRVIGLLRVMFDPRMTLQQQVSAQLESHFGDKVFTTVVPRNVRLAEAPSYGMPGVVYDRASRGAQAYIAFGAEMIERVKELD
>NZ_CP044089.1|WP_003818286.1|1218546_1219353_-|GNAT-family-N-acetyltransferase
MPAVLAVPAAHPTPAAGGELARLEEAALNATTVREQMLYEGWLVRWAPSRAKRARCVNVLGLSTRPLDERLAYCTRWYARHGVPLIVRLTSIGPDFSLDAQLHERGFVAFDPTCVMAAPVVPFTAQAPSGLVFERTTPGRFAQEAGRLRGHDDAATAEHAARLQAAPLENLPLLVRDASGECIAAGLAAFDAGLVGLFDIVTAPQRRRQGCGAAVLKYLLEQASHAGARQAYLQVEPQNTAARALYARFGFVDRYTYWYRSMSEATPV
>NZ_CP044089.1|WP_003806881.1|1217585_1218503_-|ParB/RepB/Spo0J-family-partition-protein
MATKKPKGLGRGLDALLGADVPAIDNIGKAPAAAPEGPPATLPVSKMRAGKYQPRTRMDEGALNELAESIRTQGIMQPILVRALGADAPGQYEIIAGERRFRAAQLAGLKEVPVLVREVADENAAVMALIENIQREDLNPLEEAHGVRRLLDEFGLTHEQAAQAIGRSRSATSNLLRLLNLAAPVQTMLLAGDVDMGHARALLAVDAATQIQLANQVIAKRLSVREAEKLVARAQKDVDAAPRKKGNGASRDVTRLEEALSDHLGTRVALKVGAREKGQIVIDFHGWEHLNSLLERQGLSGVVDA
>NZ_CP044089.1|WP_003818288.1|1216591_1217593_-|asparaginase
MPEARLPRIAVLATGGTIAGAQTDAASGAYRAGSYGVGQLLAAVPQLAGLARIGAEQIANVGSQNMSHAVWRQLALRAAALCDDPATDGIVITHGTDTLEETAYFLSLVLPVDKPVVLLGAMRPATALSADGPVNLYNAVALACHPAARGRGPLVVMNEDIHLARHVQKMAASGIAAFASPNAGRAGVMQGGRPVFHARAERQAADALLRPDELPQQAWPRVDIVHACVDLDGELIDFMAGRAQGIVLAGVGDGNATDAALQALQRASARGVAVVRASRTGSGRVGRNIEIDDDACGFIAAGDLSPQKARVLLALGLCQTRDTARLQALFDSR
>NZ_CP044089.1|WP_003806883.1|1214805_1215996_-|elongation-factor-Tu
MAKGKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLSNKFGGEARGYDQIDAAPEEKARGITINTSHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIIVFLNKADMVDDAELLELVEMEVRELLSKYDFPGDDTPIVKGSAKLALEGDKGELGEQAILSLAQALDTYIPTPERAVDGAFLMPVEDVFSISGRGTVVTGRIERGVVKVGEEIEIVGIKPTVKTTCTGVEMFRKLLDQGQAGDNVGILLRGTKREDVERGQVLAKPGSINPHTDFTAEVYILSKEEGGRHTPFFNGYRPQFYFRTTDVTGTIDLPADKEMVLPGDNVSMTVKLLAPIAMEEGLRFAIREGGRTVGAGVVAKIIK
>NZ_CP044089.1|WP_003806884.1|1214186_1214567_-|preprotein-translocase-subunit-SecE
MSNTSIETVTSTADRIKLGLAVLVVIAGIVGFSMLDAQPMVARIGVFVGGLVVAALLAWFSEPGRRTLSFAGESYNEVKRVSWPTRKETIQMTGIVFAFVAVMGLLMWVLDKGIEWVLYGLLLGWK
>NZ_CP044089.1|WP_003806885.1|1213643_1214177_-|transcription-termination/antitermination-protein-NusG
MSKRWYVVHVYSGMEKSVQKALNERIERAELQTSFGRILVPSEEVVEVKGGQKSITERRIFPGYVLVEMDLTDETWHLVKNTNRVTGFLGGSGNRPTPISEREVEKILNQMEEGVEKPRPKILFEVGEMVRVKEGPFADFNGNVEEVNYEKSKVRVSVTIFGRATPVELDFSQVEKT
>NZ_CP044089.1|WP_003806886.1|1213148_1213580_-|50S-ribosomal-protein-L11
MAKKIVGFIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAKTQGMEPGLPIPVVITAFADKSFTFIMKTPPATVLIKKASGVQKGSAKPHTDKVGTLTRAQAEEIAKTKQPDLTAADLDAAVRTIAGSARSMGITVEGV
>NZ_CP044089.1|WP_003816068.1|1224553_1224760_-|cold-shock-protein
MAQKGKVKWFNADKGYGFITPDSGGTDVFAHFSAIQGRGYRSLNEGQEVEFEVKDGPKGPQAAEIRPL
>NZ_CP044089.1|WP_003818281.1|1225132_1226326_+|pyridoxal-phosphate-dependent-aminotransferase
MLVHIPTIAMIRSKLPDVGTTIFTVMSRLAIEHKAINLGQGFPDFDPDPELCALVGKAMAAGHNQYPYMPGVAPLREAIAAKVKTLYGHAYDPETEITVTSGATEALMATVLAAVGPGDEVVVVEPCYDSYLPAIRLAGGTAVPVPLRAPTRDDPYYRIDWQRVRDAIGARTRLLMLNFPHNPTGAVLDESDLDALESIVRETGVLLLSDEVYEHIVFDGKPHASLSRRPLLAEHAFVISSFGKTYHTTGWKVGYCCAPRQLSAELRKVHQFMVFTVSSPMQFALAEYMANPKPYLDLPAFYQAKRDRLAAGLANTRFRPLPSPGTFFMLADYSEITKHAEADFARHLTIDHGVTVIPVSAFYQNPAAPESNHHLVRFCFAKQDATLDAAIERLAHV
>NZ_CP044089.1|WP_003816065.1|1226401_1227925_-|tripartite-tricarboxylate-transporter-TctA
MSGILDHLAIGFGVAFSLTNVLVAAIGSFFGTMVGVLPGLGPINGVAMLIPIAFAMNLPPETALILLAAVYVGAEYGGRITSILLNVPGEASAIMTTLDGYPLARQGLANVALSLSAWSAFFGAIVSVTGIILLAPLLAKWALAFGPAEYFVLMVFAFCCLTSLLGKQPVKGVLAAMIGLGISVVGVDSNSGVYRYTFDSVHLSDGIDFVVVVIALFAVSEMLEMLEKVVAGHSIEVKPSGRKLFNLKELSFTWWSVVRSSLVGFGVGVLPGAGASVAAAVAYSQEKRIIESKDPDAKFGKGDMRGLVAPESAATASAIGSFVPMLTLGVPGSGTTAVMMGALTLYNITPGPVLFDSKPELVWGLIASLFIANVLLFIMNVPMVRVFSKVLAVPAWMMVPGILCISYIGVYAINAGTFDLLMVVAIGALGYFLRKFGVPMAPLVLGVVLGDMMEQNLRRALSITNGDPVVLYSSPVSIGLWIAAAAVVIVPQLMRRLSARRRQAAQS
>NZ_CP044089.1|WP_003818279.1|1227921_1228359_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MNDRMLGVFALILAAFMTWAGWDIEAPFAYEPVGPRAFPMLVALIIGLCGLRLVYKGGHQVETNSAGANARIALMVAYAAAYAFLFQWLGFVIATALMTIAVGRLFGGNWIKCAAGGLIMGVLFFLLFDKVLDVVLPAGLLEGLL
>NZ_CP044089.1|WP_003816062.1|1228463_1229468_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MHTLAKFRATAAALAGLCALFIGNAAHAAGDEPRRPECIAPAQPGGGFDLTCRLATEGLKQSGALKAPMRIVYMPGGIGAVAYNNIVAQHPGEAGTIVAFSGGSLLNLAQGKFGKYSVDDVRWLAGIGADYGVAVVRNDSPYTDLKGLMEAFKQDPTKIVLGAGGTVGSQDWMKAALTAKAAGVDFKKMRFVAFEGGGEAVTALRGGHIQAYMGDAAEAFTMLEGGAPIRVLAVFNSERLPGKLNNVPTAKEQGYDIVWPIIRGFYVGPKVSDKDYQFWVDAFDKTMTSPEYAKLREQQGLFPFSKTGKDLDDYVKQQVKNYAELADSFGLIKK
>NZ_CP044089.1|WP_003818277.1|1229588_1231004_-|sensor-histidine-kinase
MLLWWLIPALVFVMTGALWLSNQQLRNQVDIAYDRSLSGALRSIDHNISTASGGLSLEQPYLMLEFFELTANGNVYYRVATEDGLAEIGNPQLPLPPQPLVSGQPQFFYAEYLGQPVRVAALARPMDPPLYNDKGGRIIVQVAESLETRQDFLHRALVRSVERDLAVVMISVLVVIWSVFMALRPLERLREEVASRSADDLSPVSASEMPGEVQPLIHAVNLHMARFTALARVQRQFLDDASHQLRTPLSVLRTQTAYALRETDPQEVRTALLAMQDGLDRAVRTTNQMLALARAKDASLAEGGLPLETVDLAELADGVIRALLPAARARQLDLGLDVQAAPVRVQAVEWLLREALSNLVDNAIRYTARGSEVTVKVHTEGGHAWLVVEDNGPGMSAEDIARASVRFRRGAAGKNKSGAGLGLAIVRTIIEIHGGQLVLENRQPQPGLRAALVFSLGFKGNAALPHEIVVI
>NZ_CP044089.1|WP_003816057.1|1231038_1231719_-|response-regulator
MRILLIEDEAELARWLSRSLARHAGFVVEWADDGLLAERRLAVEEFDAIILDLGLPGMDGHTLLTRIRARDDRTPVLVLTARDSLAERVGTLHQGADDFLPKPFVLEELEARLTALIRRSRGREHPRLTLGDLALDTASQRFTVKGQPLALSPREHAVLRALIQRSGEPLNKQQILDRIQSSDSDVNLEAIEVLVHRLRKKLADTGVQIVTMRGMGYCLENAVDNP
>NZ_CP044089.1|WP_003818275.1|1232276_1233551_+|MFS-transporter
MTGHSTPFAGRQVLAASFVMAIYGWGMGFYGPPVFLHAVVERTGWPLQWVAGMVTLHFVAGALAVANLRRLYRLAGIPMVTFCGALGSALGTFGWAVAATPWQLAIAALVSGASWAALGAAAINALIEPWFVVRRPAALGMAYNGASVGGIVFSPLWALLIQAWGFAWAAGVVGASMVLVIAVLASLVLTRTPANTGQAPDGEAVAPRPAANPAPPARPAGRLREDRRFVTLAAAMSLGLFAQMGLVAHLYSLLVPTLGPGTAGLAMGAATGCAIAGRTIVGRIAGAGSDRRLLASYAYAIQALGALLLLAAGDTPALVWLGLLLFGSGIGNATSLPPLIAQNEFDPASVRRVVPLIVALSQAAYAFAPAVFGMLRGVSDAASAPWLFVAAAALQAAAIACLLAGRATCRCRNSKRSRPASRRW
>NZ_CP044089.1|WP_150348896.1|1233495_1234848_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MSLYAPIAAIATAPGRGGIGVVRISGPDLAELAQRLFGRPLTPRHAHYLPFRAADGEVIDEGLAIYFRAPHSYTGEDVLELQGHGGPAVLRRILARCLQAGHDLGLRPAEPGEFTRRAFLNERLDLAQAEAVADLIDASSEAAARGAMASLSGEFSQRVNDLSDRIIHLRMLVEATLDFPEEEIDFLEKYQARPTLQALTHDLDTLIAQARQGVILREGLHVVLAGKPNVGKSSLLNALAGDDIAIVTPIAGTTRDKVVQEIHIDGVPLHIVDTAGLRDTDDAVESIGIERTWKEIERADVILHLQDVTQPPDHLDAQIVRRLPARTPVLNVFNKVDLLDAAFQGQPDSLAISARSGIGLDALRRRLLQLAGWNPGAESPWLARERHLHALQQAAQHLEIATEHAREDDRVLDLFAEELRLAHEALTGITGKFTSDDLLGEIFSSFCIGK
>NZ_CP044089.1|WP_004565926.1|1234964_1236551_+|ABC-transporter-substrate-binding-protein
MISRLSRVVTCGSVIVALALGGASAALARDLVVALKTEPSSMDPQYHALTPNTQISQTIFDPIVRVDEQLKPQPALAESWTVDGKVWTFKLRPNVKFSDGTPFTAEDVVFTYDRIPKVPNSPSPFTLYLGAVAKTEAVDPLTVRITTKDVTPLLLVNLAQLPIMSKKAASGPAPEGKTTTELNSGNGLIGTGPYKFVSWKRGAEFVLARNENYWGKPPAWDKVTYRPMTNAAARVAALLAGDVDMIEDPPTDDLPKLKADKKLYVEETPSVRVVYLALDQYAEPSPGVQGTDKNPMKDKRVREALSLALNRDAIVDRVMGGVAKPAGNLLPYPMFGSSKEHSQAPKADVEKAKALLKEAGYPNGFSITLGSPSGRYVNDAKVAQAIASMWTRIGVKTSVDSMAPPVFFKNRDSYAFSAYLAGWSVTSGEMSNALTSLLVTRNPEAGLGTTNRSRYSNPAMDELVKQASSTMDDAKRAELLQKASNLAMDDYAMLPVHFELSVWAMKNDIRYTGRPDQTTLVQYATVKK

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Crispr_ID: NZ_CP044089_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_2

1650346-1650431

Orphan

Consensus_repeat	Method
AGGTGCCTGTCCCGGCGGGGACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_2

>merge|NZ_CP044089|2|1650346-1650431|CRISPRCasFinder
AGGTGCCTGTCCCGGCGGGGACAGATACCGTCTTGGCGGTCAAGCGTCGATGGCGTACGGCAGTGTGCCTGTCCCGGCGGGGACAG

>NZ_CP044089|2|1|1650346-1650431|CRISPRCasFinder
AGGTGCCTGTCCCGGCGGGGACAG	ATACCGTCTTGGCGGTCAAGCGTCGATGGCGTACGGCA
GTGTGCCTGTCCCGGCGGGGACAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_033469944.1\|1648776_1650291_+\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|236211
NZ_CP044089.1\|WP_003815289.1\|1660397_1661543_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380643
NZ_CP044089.1\|WP_003817796.1\|1644389_1645382_-\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|224981
NZ_CP044089.1\|WP_003817798.1\|1643655_1644393_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235852
NZ_CP044089.1\|WP_004567860.1\|1652074_1652578_+\|cupredoxin-family-protein	unknown	unknown	gnl\|CDD\|259873
NZ_CP044089.1\|WP_003817793.1\|1646202_1647351_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
NZ_CP044089.1\|WP_003817791.1\|1647463_1648693_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
NZ_CP044089.1\|WP_003817794.1\|1645495_1646158_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
NZ_CP044089.1\|WP_003815296.1\|1658370_1658961_+\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|227840
NZ_CP044089.1\|WP_003817781.1\|1656109_1657270_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP044089.1\|WP_015041960.1\|1642754_1643576_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|235991
NZ_CP044089.1\|WP_003817802.1\|1641805_1642666_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
NZ_CP044089.1\|WP_003817778.1\|1658994_1660323_-\|amidase	unknown	unknown	gnl\|CDD\|223232
NZ_CP044089.1\|WP_003815297.1\|1657286_1658081_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP044089.1\|WP_003817803.1\|1641441_1641678_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_003817783.1\|1655378_1656113_-\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|119339
NZ_CP044089.1\|WP_003817786.1\|1652620_1654396_+\|copper-resistance-system-multicopper-oxidase	unknown	unknown	gnl\|CDD\|273649
NZ_CP044089.1\|WP_003817804.1\|1639516_1641145_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173863
NZ_CP044089.1\|WP_015041958.1\|1654442_1655372_+\|copper-resistance-protein-B	unknown	unknown	gnl\|CDD\|377498
NZ_CP044089.1\|WP_080700659.1\|1650579_1651560_-\|cytochrome-c5-family-protein	unknown	unknown	gnl\|CDD\|225784

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_033469944.1\|1648776_1650291_+\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|236211	PRK08268, PRK08268, 3-hydroxy-acyl-CoA dehydrogenase; Validated.	0
NZ_CP044089.1\|WP_003815289.1\|1660397_1661543_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380643	cd19988, PBP1_ABC_HAAT-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	1.28709e-110
NZ_CP044089.1\|WP_003817796.1\|1644389_1645382_-\|nitronate-monooxygenase	gnl\|CDD\|224981	COG2070, COG2070, Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only].	2.78466e-76
NZ_CP044089.1\|WP_004567860.1\|1652074_1652578_+\|cupredoxin-family-protein	gnl\|CDD\|259873	cd04211, Cupredoxin_like_2, Uncharacterized Cupredoxin-like subfamily. Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins because they have an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. Majority of family members contain multiple cupredoxin domain repeats; ceruloplasmin and coagulation factors V/VIII have six repeats; Laccase, ascorbate oxidase, and spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase and the periplasmic domain of cytochrome c oxidase subunit II.	2.20196e-61
NZ_CP044089.1\|WP_003817793.1\|1646202_1647351_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	3.56115e-148
NZ_CP044089.1\|WP_003817791.1\|1647463_1648693_+\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	2.87761e-177
NZ_CP044089.1\|WP_003817794.1\|1645495_1646158_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	1.06275e-27
NZ_CP044089.1\|WP_003815296.1\|1658370_1658961_+\|cysteine-dioxygenase	gnl\|CDD\|227840	COG5553, COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only].	6.40342e-49
NZ_CP044089.1\|WP_003817781.1\|1656109_1657270_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	2.21282e-158
NZ_CP044089.1\|WP_015041960.1\|1642754_1643576_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|235991	PRK07327, PRK07327, enoyl-CoA hydratase/isomerase family protein.	0
NZ_CP044089.1\|WP_003817802.1\|1641805_1642666_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	3.8144e-73
NZ_CP044089.1\|WP_003817778.1\|1658994_1660323_-\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	7.09028e-140
NZ_CP044089.1\|WP_003815297.1\|1657286_1658081_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.29699e-70
NZ_CP044089.1\|WP_003817798.1\|1643655_1644393_-\|enoyl-CoA-hydratase	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	1.11694e-74
NZ_CP044089.1\|WP_003817783.1\|1655378_1656113_-\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	6.2421e-36
NZ_CP044089.1\|WP_003817786.1\|1652620_1654396_+\|copper-resistance-system-multicopper-oxidase	gnl\|CDD\|273649	TIGR01480, unnamed_protein_product, copper-resistance protein, CopA family. This model represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds].	0
NZ_CP044089.1\|WP_003817804.1\|1639516_1641145_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
NZ_CP044089.1\|WP_015041958.1\|1654442_1655372_+\|copper-resistance-protein-B	gnl\|CDD\|377498	pfam05275, CopB, Copper resistance protein B precursor (CopB). This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every organism. CopB serves to extrude copper when it approaches toxic levels.	2.54472e-103
NZ_CP044089.1\|WP_080700659.1\|1650579_1651560_-\|cytochrome-c5-family-protein	gnl\|CDD\|225784	COG3245, CycB, Cytochrome c5 [Energy production and conversion].	4.08911e-26

>NZ_CP044089.1|WP_033469944.1|1648776_1650291_+|3-hydroxyacyl-CoA-dehydrogenase
MSEIQTIGIVGAGAMGRGIAQIAAQAGVLVRLYDTNAAAVEAARDALRQTWDKLAQKGKLSEADAQAALARIAPAAALADLADCQLVIEAVIERLDVKRDLFAALEEIVAADCVLASNTSSLSITAIAAACKRPQRVVGYHFFNPVPLMKVVEVIDGLRSDPAVGDALAELARRMGHTPVRAKDMPGFIVNHAGRGMNTEGLRVAQEAVAPFDQIDAIMREQAGFRMGPFELLDLTALDVSHPVMESIYRQFFDEPRFRPSPITTVRLAGGLIGRKAGEGFYAYPDGQKQVPAEPAAPALRAGLRAWVSPAHPDGHARASALLRGMAVELAEGATPPQDALIIVTPYGEDVSTCVQGQRLDGARTVGLDTLYAFEAGRRRTLMVSPATASNWRDDAHALVASDGAPVSVIEDSPGFVAQRIVACIVNIASDIAQQRIATPQDIDRAVTLGLGYPVGPLALGDKLGGARLLEILHNMQRVTGDPRYRPSLWLQRRVQLGLSLLHG
>NZ_CP044089.1|WP_003817791.1|1647463_1648693_+|CoA-transferase
MSQRPAPLTGIRVLDLTRVLAGPWCTQNLADLGAEVIKIERPGAGDDTRAWGPPYLKDAAGNDTTEAAYYLSANRNKLSVALDIATPRGAELVRELAQQCDILVENFKVGGLRKYGLDYESVKAINPRLIYCSITGFGQTGPYASRPGYDFMIQGMGGLMSITGERDDLPGGGPQKAGVAVTDLMTGMYSTVGILAALHERNRSGLGQHIDMALLDCQVAMLANQNLNYMTSGKAPRRAGNAHQNLVPYQVFAVSDGHLIVAVGNDSQFRNYCRVIDLPELADDPRFATNPQRVQNRDELVPLLAERMATGERDAWLAALESAGVPAGPINTLDQVFEDPQVVARQIRRELPHPSAGTVPTASSPLRFSDSPVEYRRAPPLLGEHTRQVLSERLGLSETEIQALAAGQG
>NZ_CP044089.1|WP_003817793.1|1646202_1647351_+|acyl-CoA-dehydrogenase
MALDNETLNLLLDAVRRFVNDRLVPAENELAETGRIPDEIVQEMRDLGLFGLSIAADYGGLGLTMEEEVRVVFELGQTSPAFRSLAGTNIGIGSQSIVLAGTDDQRQRYLPKLASGELIGSFALTEPDAGSDAMALRTSAVRDGDHYVLNGTKRFITNAPVAGLFSVMARTAPERRADSISCFLVEAGTPGVTLGKPDKKMGQAGALTCDVVFDNCRVPAEALLGGKEGTGFRTSMRVLDKGRLHIAALCVGIAERLVRDAVRYALERKQFGQPIAEFQLVQAMIADSQTELYAARSMVLDAARKRDLGQNVTMEAACSKLYATEMVGRVADRAVQIHGGAGYISEYAVERFYRDVRLFRIFEGTSQIQQLVIARETLKAYA
>NZ_CP044089.1|WP_003817794.1|1645495_1646158_+|TetR/AcrR-family-transcriptional-regulator
MQAGARLARQDNAMADAPAPAPKRARAGRPPTLAAPRERILEEAARLFARSGYENSSVADLAAAIGVSKAALYHYFPTKQDIYDAIILETLAGLLQAVTREVERQHEACERLRAFMVGHARYFARHHEQFVTMLIGYSGMALPERADAAQLRDRYEQLLRDLLEQGMAAGTLRRLDVAATGRAVLSMLNWMVRWYKPGQGDSAEQIADGYYDLLFNGLRI
>NZ_CP044089.1|WP_003817796.1|1644389_1645382_-|nitronate-monooxygenase
MNARDTAMPHPVVAELYASMTLPVVCSPMFIVSNPKLAIAQCVSGVMGSFPALNARPQSLLGDWLDEVEAGLAEHRRAHPDGIVAPYAVNQIIHQSNDRLEHDLDVCARHRVPYIITSLRAPGDLVAGVHAWGGKVFHDVTTVRHAEKALEAGVDGLILVCAGAGGHAGTLSPFALVSEVRRFYDGPLVLSGAITSGQGILAALAMGADFAYMGTRFIATAEANASEAYKQAIVDASASDVLYTPFFTGIPGNYLKASIVAAGLDPADLPAAEAASSNFGTTRAKPWKDIWGAGQGVGGIASVLPARELVASLRAEYAQAQARLGARNLG
>NZ_CP044089.1|WP_003817798.1|1643655_1644393_-|enoyl-CoA-hydratase
MNSLLTERDAAVLTLTINRPERRNALDTATYDALAAQLRAADADTGLAAVILTGAGDHFTAGNDLRDFQAERPAGDSPALRFLRALVDTDVPVLAAVEGHAVGVGVTLLQHCDFAFAAGTARLRMPFVALGLCPEGASSLLLPRLAGMRKAAEWLLQGRAFDAAEAHAAGLLTGVTEPGQALAAARAVAADLAAQPRQALRVSKRMLRQADRAAIHATLDHEAEQFRERLRSPEAQQAFARFFNK
>NZ_CP044089.1|WP_015041960.1|1642754_1643576_+|enoyl-CoA-hydratase/isomerase-family-protein
MSETDTNPEHYARYRALRIRRHPEGILELVMGAKDASGKLSTADERLHRELADVWRDIDTDDQTRVVVIRGEGNGFSGGGDLGLVQQMAEDFEVRTRVWREARDLVYNIINCNKPIVSAMHGAAVGAGLVAGLLADISIAARDARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYYLLLCDAVSGEEAERIGLVSLCVDRAELLSKAFEVAGRLAAGSQTAIRWTKYALNNWLRMAGPSFDTSLALEFMGFGGPDVHEGIKSLREKRAPDFR
>NZ_CP044089.1|WP_003817802.1|1641805_1642666_-|NAD(P)H-hydrate-dehydratase
MDTSSSSLPAIERQHLPALFAARPTDAHKGSCGTLGVIGGGPGMVGAALLAARAGLKVGAGKVLVGLVAETPPLPCDPMQPELMLRDFRGLLEAGLGIDAWTAGCGCGMDALAANALSELFQLRGDAALVLDADGLNLLAAGAVQPRWGDAPVVLTPHPAEAGRLLGLSTEAVQADRPAAARTLAARYGAWVVLKGAGSIVCDPAGVCRINRTGNPGLATAGTGDVLAGILGALLAQRIAPEQAVPGAVWLHGAAADALVTHGIGPIGLTAGELADSARRLRNSRA
>NZ_CP044089.1|WP_003817803.1|1641441_1641678_-|hypothetical-protein
MSDLTLSHNARLTDSLERELLRGAMEDQSNTIRPLAAVKAAAAGVGRGVRAVFAFIDEVNESMNRARAQSAHYTGSQW
>NZ_CP044089.1|WP_003817804.1|1639516_1641145_-|ABC-transporter-substrate-binding-protein
MKLRTTLALLATSAGLAAAPGSASAQSLKIALSSEPTSADPHYHKQTQNDAFSAHVYSSLIGRDADMKLVPALATSWKNLDDLTWEFKLRDDVKFSNGKPFTSEDVLFTICRTLNNETNVSQSYMDTTKRIADVQTPDAHTVIIKTAAPLPLLPAELARSLPIVWNGIVEHGKLTFNPKEGCGVTGPWPTVADFNNGKDAIGTGPYKLKSYVKGTGIELERNDNYWGPKPYWKDVKMVPVPNAGPRLTGLLSGDFDVIENPAARDLPRIKSNPQFGFVATPSTRLIFFQPDVGRNPSPLVKSADGKNPLQDLRVRQAISMAIDRKTIVTRLMDGIATPAYQYMPDGMFGGVPNAPEIKYDPEGAKKLLAEAGYANGFELTISTPNDRYVNDGQIAQAVAQYLSRVGIKANVDAMTASLYFPKRAKREFSFSMGGWPAEVGEASALFQLWVASLDSPRSLGTSNYGGFSNAEFDKVFTEALVTVDVAKREKLLQQSTQIALDNVPLIPLHFESSIWAFRKGLTYEGRRDQFTLAMSVKPADQK
>NZ_CP044089.1|WP_080700659.1|1650579_1651560_-|cytochrome-c5-family-protein
MLCSDWIVSCRLLGVPRYPDSQDLVMSNEQEHIEEHVSPIKTPKQLITTIVLAFVVPIIIIIMLVNVVTSGTKVGAGSDTLGEEAVAKRIAPVAGFELVDANAPKVHKTGEQVFTAVCTACHTAGVAGAPKMGDNAAWAPFIKAGYDAMLNVALHGKGGMPAKGGNPALSDYEVARAVVYMANQSGGSLPEPAAPAEEGAKPAEAAAPAAAAAPAPAPAAPAAAAPAPAAAAAAAPAAPAEQQAAVNPAGEKLYKATCFACHATGVANAPKFGDKAAWAPYIQTGMDAMLKVAMQGKGAMPPKGGAATASEDDIRAAIEYMVNAAK
>NZ_CP044089.1|WP_004567860.1|1652074_1652578_+|cupredoxin-family-protein
MRARVYAVRMAAAAAACGISFGAAASGAHGGGHGGGHGAATAGATAIGKPGVASKASRTVNVDMTDAMRFTPDQIAVKAGETVRFKVTNSGKIRHEMVLGTDADLGAHYQMMLKDPGMRHEEPNSVSLDAGKSGEIVWQFDKAGRVAFGCLEPGHYPAGMKGAVSVK
>NZ_CP044089.1|WP_003817786.1|1652620_1654396_+|copper-resistance-system-multicopper-oxidase
MSRAVSNQRRRFVQGLAGGGVLAGLGLWRQAAWAQPGAAQPEVLSGTEFNLEIGRTPANFTGAARMATTVNGSIPAPILRWREGDTVTLRVTNRLDEDTSIHWHGILLPTGMDGVPGLSFPGIRPGETFTYRFQVRQSGTYWYHSHSGFQEQTGLYGAIVIEPRRADPVRAERDHVVLLSDWTDEDPMSVFRKLKVMPDYYNYIQPTVDNLIDDARKQGWASALGERLMWQQMRMNQTDLADVSGATYTYLANGKSPAGNWTGLFKPGERVRLRFINGSAMTYFDVRIPGLKMTVVAADGLPVRPVEVDEFRIAVAETYDVIVEPAEDRAYTIFSQAMDRSGYARATLAPREGMQAEVPALDPVQVLTMMDMGMAHDMPGMDHGAAGQQGAAMDHGAMGGMDHAAMGHGSGEASGGMVEVRHPYPAEHGPANSMLPDIVTTRLDDPGVGLRDNGRKVLTYADLRSMVEPEDNRAPTREIELHLTGNMDRYMWSFNGLKFSQAKPIVLKYGERVRFVLVNDTMMTHPIHLHGLWSDLESPDGNFQVRKHTISLNPAQRISYRVSADARGNWAYHCHLLYHMEAGMFRAVVVE
>NZ_CP044089.1|WP_015041958.1|1654442_1655372_+|copper-resistance-protein-B
MAASLGLAAAAASAWAQAPAMDHGSMPGMNHGAAPAPAMDHGSMPGMDHGAPSAPAMDHGSMPGMDHGAAPAPAIGALPSSDGAGDQSYAAYGIHSHMMDDMVTSQLLFDKLGMTYDRDRRTGLQWDGQFWVGRDLDKLWIKSEGERVGGRSDGKVEAFWNRTISPFWDLQVGARRDFGTGPKRNWGAIGLQGVAPYNIETEVTAYVGGSGRTALALKAEYDLLLTQRLVLTPEIEASVYGKDDKARGIGAGLSDASFSLRLRYEITREVAPYVGVSFGRKFGKTASYASEEGESRSERAIMAGVRIWF
>NZ_CP044089.1|WP_003817783.1|1655378_1656113_-|enoyl-CoA-hydratase/isomerase-family-protein
MSAMSASLPLAITRQPAAWTFTLSRPEKRNALSAELVEALIDGVDAAHREQVPLLVFAGAGRNFSAGFDFTDYETQSEGDLLLRMVRIEMLLQRVAGSPSLTLALAHGRNFGAGVDLFAACKWRYCTPEAGFRMPGLKFGLVLGTRRFRDIVGADQALSILGSARAFDADEARRIGFVRDCAAQAQWPALIDAAAEAATALDPATRATLHRVLRDDHDDADLAALARSAAQPGFKARIRDYLAQ
>NZ_CP044089.1|WP_003817781.1|1656109_1657270_-|CoA-transferase
MNQESTLAGVRVIEICNVAAGPFCGMLLADMGADVVKIEPPGTGDTLRSWAPITDGYSENFASLNRNKRSVTLNLKNEAERDAAIELIAGADVLIENNRPGVMDRLGLGQQAMRARNPRLVYCSVSAYGQSGPRSQEGGFDLTLQAMSGLMSVTGEEGGAPVKCGVPVCDFTAGLYAAFAIAAALRRVQADGQGTHIDVSMLGATLGIAALQTSQYFGTGVDPVKLGSAHPRNAPYQVFRCKNGYFGMAAGNNSLWKAVCKVVERDDLHADPRFANPTDRAEHQVALRDILEAIFAEHDSHAWLERFRQAGVPCAPINDYSEVLADPQVEHMDWVQDLELPNGVRTRTFVSPVRFDARTAGVMRRPPALGEHNDEILSALAARPAG
>NZ_CP044089.1|WP_003815297.1|1657286_1658081_-|IclR-family-transcriptional-regulator
MRCKGIRHMDKTLLKGLTVLEAISRLDGATPTLDQIAEEIGLTRSNTHRTLQTLAHAGYVRRDPATGSYQCTLKLFELGARQLASLDARKLAPPFMGELARLTNETVHLSVLDGLDVVYVDKLDSPQPLLAYSTVGGRAPAYAVATGKALLACQTADYLDHYGAAIKRHTEDTHVSLLALKQELADVNRIGYAINRGEWRQGIGGIAAPIFNGLDKAVAALGISGPLERLTNQKMREYAPLVQQAARQLSAHMGYRGGYFGGAA
>NZ_CP044089.1|WP_003815296.1|1658370_1658961_+|cysteine-dioxygenase
MSERLLNTVVALGQLVERTGLQEAAILAQARQLIAGLVAHDDWLPDEMAQPHPEYYRQYLLYGDPRDRYSLVSFVWGPGQKTPVHDHTVWGVIGMLRGAETDQPFRRAADGRLAPEGPGKVLRPGDVACVSPSIGDIHQVSNAYDDRVSISIHLYGGNIGRIRRSVYDPQTGASKAFVSGYSNAMTPNLWAAPNAG
>NZ_CP044089.1|WP_003817778.1|1658994_1660323_-|amidase
MLTIAALASAYRTRQTTPSATLRDLLDRIAVSPLNSFISVDPETVMRQAADADAAFAGGAPAGALHGIPVAVKDLIDVAGMRTTMGSQQYANQASAERDAQVVARLRAEGAIIVGKTNTHEFAYGPTGDRSYFGAACNPRDPARMTGGSSSGSAAALGAGLCAAALGTDTSASIRLPAALCGVVGLKPTYDLLPRAGAFDLSQTLDHVGPMSATVRDNAVLLDALAGQPAHSYARLAGQSVRGRTVGLATGFYLDYLDAPVRQALEQAQEAFRQAGAQVVPIEIAQVQAIYEAQQLVLKTEAYARHLRALTTDAPYQDEVRARLLTGADVLAVDYLQAMAMRTVARRAFDEALAQVDVLLCPTCGLTAPLRDQRTTALDGQEYSTTWLLTRLTAPTNLSGHPSLSVPFGADSQGLPISMQLIGRHLDEAVLYQFGQALEDAA
>NZ_CP044089.1|WP_003815289.1|1660397_1661543_-|ABC-transporter-substrate-binding-protein
MIAFAPRTLAVASIAATVALAGCGQKEEQAAAGATPLRIGIIESVTGPAASYGDAHNKGTRLAVEEINKAGGFNGVPLEVHGEDDKSDPATGINAAKKLITQRKVDAIVGSAASLVTIAFSKENEKYKVPLVNGMAGSPTITEQGFQYTWRIKITDNQLDTKAIEHYVQNKNARKVAFLAENSDYGKPPTKAAADRARELGAEVVAYEEYNRGETDFKAQLTNIRDRAPDVLFVHGYYTEGSIIARQIRELGLKTQLIVNEGQGVPKFQELAGAAAEGAVFPTTWLPGLSDARSKQFETAYQARYNSLPGAFDAGSYEAVYTVVEAARKGGGTKPEQIQAGLAQLQGFETLLGPVRFDKKNQNDGSIRLARFNNGKIEPLQ

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Crispr_ID: NZ_CP044089_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_3

1989329-1989422

Orphan

Consensus_repeat	Method
GTGCCTGTCCCGGCGGGGACAGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_3

>merge|NZ_CP044089|3|1989329-1989422|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCACGCCCGCACAGCGGGCGCAGCGTGGGGGGGTTCCTGGGCCCGGGTGCCTGTCCCGGCGGGGACAGGCAC

>NZ_CP044089|3|2|1989329-1989422|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCAC	GCCCGCACAGCGGGCGCAGCGTGGGGGGGTTCCTGGGCCCGG
GTGCCTGTCCCGGCGGGGACAGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003814704.1\|1986852_1988253_+\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP044089.1\|WP_003814711.1\|1983619_1984075_+\|multidrug/biocide-efflux-PACE-transporter	unknown	unknown	gnl\|CDD\|226610
NZ_CP044089.1\|WP_150348931.1\|1982519_1983623_+\|ChbG/HpnK-family-deacetylase	unknown	unknown	gnl\|CDD\|212118
NZ_CP044089.1\|WP_003814709.1\|1984080_1985004_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|378820
NZ_CP044089.1\|WP_003814699.1\|1989619_1991743_+\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
NZ_CP044089.1\|WP_003820703.1\|1991739_1992258_-\|MgtC/SapB-family-protein	unknown	unknown	gnl\|CDD\|224204
NZ_CP044089.1\|WP_003820699.1\|1985749_1986664_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP044089.1\|WP_003820707.1\|1996379_1997357_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
NZ_CP044089.1\|WP_015041882.1\|1998681_1999710_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|366103
NZ_CP044089.1\|WP_003814694.1\|1992368_1993124_+\|TerC-family-protein	unknown	unknown	gnl\|CDD\|223930
NZ_CP044089.1\|WP_003820704.1\|1993320_1994553_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP044089.1\|WP_033450536.1\|1994545_1995331_+\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|181723
NZ_CP044089.1\|WP_077274092.1\|1982291_1982600_-\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP044089.1\|WP_033450541.1\|1999776_2000970_+\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|180775
NZ_CP044089.1\|WP_033461063.1\|1980712_1982332_+\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|224720
NZ_CP044089.1\|WP_003814701.1\|1988785_1989256_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_CP044089.1\|WP_033472573.1\|1995397_1996369_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
NZ_CP044089.1\|WP_080605921.1\|1997494_1998655_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP044089.1\|WP_003820698.1\|1985093_1985753_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP044089.1\|WP_003820700.1\|1988352_1988697_+\|TIGR01244-family-phosphatase	unknown	unknown	gnl\|CDD\|225984

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_003814704.1\|1986852_1988253_+\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.52472e-110
NZ_CP044089.1\|WP_003814711.1\|1983619_1984075_+\|multidrug/biocide-efflux-PACE-transporter	gnl\|CDD\|226610	COG4125, COG4125, Predicted membrane protein [Function unknown].	2.35069e-54
NZ_CP044089.1\|WP_150348931.1\|1982519_1983623_+\|ChbG/HpnK-family-deacetylase	gnl\|CDD\|212118	cd10807, YdjC_like_3, uncharacterized YdjC-like family proteins from bacteria. This subfamily contains many hypothetical proteins, and belongs to the YdjC-like family of uncharacterized proteins from bacteria. The YdjC-family is represented by an uncharacterised protein YdjC (also known as ChbG) encoded by the chb (N,N'-diacetylchitobiose, also called [GlcNAc]2) or cel operon in Escherichia coli, which encodes enzymes involved in growth on an N,N'-diacetylchitobiose carbon source. The molecular function of this subfamily is unclear.	1.96521e-93
NZ_CP044089.1\|WP_003814709.1\|1984080_1985004_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	2.97616e-21
NZ_CP044089.1\|WP_003814699.1\|1989619_1991743_+\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
NZ_CP044089.1\|WP_003820703.1\|1991739_1992258_-\|MgtC/SapB-family-protein	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	1.24362e-44
NZ_CP044089.1\|WP_003820699.1\|1985749_1986664_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.28877e-09
NZ_CP044089.1\|WP_003820707.1\|1996379_1997357_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.29992e-59
NZ_CP044089.1\|WP_015041882.1\|1998681_1999710_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|366103	pfam00441, Acyl-CoA_dh_1, Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	7.97783e-13
NZ_CP044089.1\|WP_003814694.1\|1992368_1993124_+\|TerC-family-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	1.14565e-78
NZ_CP044089.1\|WP_003820704.1\|1993320_1994553_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.64046e-118
NZ_CP044089.1\|WP_033450536.1\|1994545_1995331_+\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|181723	PRK09245, PRK09245, crotonase/enoyl-CoA hydratase family protein.	9.0736e-157
NZ_CP044089.1\|WP_077274092.1\|1982291_1982600_-\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	1.61408e-10
NZ_CP044089.1\|WP_033450541.1\|1999776_2000970_+\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|180775	PRK06954, PRK06954, acetyl-CoA C-acetyltransferase.	2.70376e-175
NZ_CP044089.1\|WP_033461063.1\|1980712_1982332_+\|glycosyltransferase-family-39-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	1.18448e-51
NZ_CP044089.1\|WP_003814701.1\|1988785_1989256_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.38587e-30
NZ_CP044089.1\|WP_033472573.1\|1995397_1996369_+\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	2.65883e-117
NZ_CP044089.1\|WP_080605921.1\|1997494_1998655_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	4.43018e-83
NZ_CP044089.1\|WP_003820698.1\|1985093_1985753_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	3.59851e-32
NZ_CP044089.1\|WP_003820700.1\|1988352_1988697_+\|TIGR01244-family-phosphatase	gnl\|CDD\|225984	COG3453, COG3453, Uncharacterized protein conserved in bacteria [Function unknown].	3.40043e-35

>NZ_CP044089.1|WP_003814701.1|1988785_1989256_+|universal-stress-protein
MFKKILIPTDGSPLSAQAANAGICFARSTGAEVVALHVTQPFAATIGFDGMAAAYAITDEDYEKASAEQAEKYLKLILDRAETAGVKAESRAVSNFNVADGIVQAAGEAGCDLIFIGSHGRSGLSRLLLGSVTAKVLSLAHTAVLVYRVKEDKDKK
>NZ_CP044089.1|WP_003820700.1|1988352_1988697_+|TIGR01244-family-phosphatase
MSAAIKPLTENFAVAPQLGPADMADVAAAGYKSVIINRPDFEGGPDQPTAADVSQAAQALGLQVEYQPVVGSAMTAADVARFAELLRTMPGPVLAYCRTGTRCTNLFAAAQQLG
>NZ_CP044089.1|WP_003814704.1|1986852_1988253_+|PLP-dependent-aminotransferase-family-protein
MRQADATLVTQLADDLARRIDEHGLRPGTRLPSIRRMAEQSGVSRFTVVEAYDRLVARGLVQSRRGAGFFVRARSASLTALASARVPQAAPETPVRVDVSWLLRNMFRETAAGMPGGAGLLPPEWLDPDMVAAAVRAVGRTVRGNLVSYGSPQGYAPLRQQLASMLQADGVPAHPERNLLTTNGVTHGLDIVARHLIKPGDTVLVEDPAWFVIFGRLAAFGARPVGVPRGPDGPDLAMLDRLAAEHKPRLYIINGAVHNPTGHTLSAGAAYDILRLAERHDFMVVEDDTYADLHPGGAMKLAALDRLERVILVGGFSKMLAASLRVGYIAAGAETLQRLTDLKMLAGLTSPELGERVVHRVLVEGQYRRHIERVRARVNEARLRSIQALQQLGLSVPHEPHAGMFVWADCGRDSEPVARNAAERGMLLAPGTLFSPSGAPSTMLRFSVAMVDTPGIWQSIAAVMAQ
>NZ_CP044089.1|WP_003820699.1|1985749_1986664_-|DMT-family-transporter
MSPPSAQASAPSASSHAPSWEGYGYGLIGVLVFALTLPMTRLAVGELSPLLVGLGRALLAAVPAAALLWLTRSRRPDRAEWSGIVLAAVGIVVGWPVASTLAMASVPAAHGAVFNGLLPLSTAVFAAWRSGERPSPAFWSFAVLGAVLVAGYALRQGHGALQPGDLWLLLAVVLGGMGYAEGARASRTLGGWRTICWALVVSVPALLPAVLWLAHDAAWPSLPVAGAFAYLAFGSMFLGFFAWYRGLAIGGIARVGQIQLLQPFLTVVAAALLFNEQVEPITYVFAVAVVLVIAGGRRAMVRKA
>NZ_CP044089.1|WP_003820698.1|1985093_1985753_-|LysE-family-translocator
MIGSDLSSLDQAPLASLSVLMPLVLFTLVNSLTPGPNNVMLASSGLTFGFRRTIPHLLGISVGFSIMLLMVGLGLGATLERLPWLYSTLKYGGAAYLLYLAWKIATSGPMESGAERGKPLTFIQAALFQWVNPKAWVMIVSVVATYTPQHGYFANLIIATLVCGVVNLPSVGVWAAFGMALRRWLHRPAAVRTFNVGMAVLLVVSLYPVGLDLLALYTG
>NZ_CP044089.1|WP_003814709.1|1984080_1985004_-|alpha/beta-fold-hydrolase
MVSLPFRLSWRRMAAVLLLAAGALGFNQLDAWQRQAIFSPQTDQQRWWREPPAGTEVFDLALPNGDKVHAWYWQSPRRDAPTVLYLHGARWNLNGSAFRMEGWTRMGYSMLAIDYRGFGQSTPLLPSEQSASQDAAAALQELARRQPDPARRFIYGHSLGGAIAIDLAARPDLPPFAGLIVESSFTSIGAMLGTMKWGWVPGATLLVTQPFASVDKLAALTTPMLLLHGTADRVVPHTMSDELYRAAQQVPADLKRLVKIEGASHSGAIRSGRIYEDAVADFVRDAGRGYAGRQGAPTPLTASRPGT
>NZ_CP044089.1|WP_003814711.1|1983619_1984075_+|multidrug/biocide-efflux-PACE-transporter
MSSSSKQTPKTIKERFLHAFFFEIIAIGLSAPVAAWAMDQPLFDMGVLTAVIAWIALLWNMVYNAGFERLERRFGVVRTMPVRVAHAVGFELGLVLIIVPLAAWWLAISFWEAFMLDIGLLMFYLPYAFFYNLAYDKLRARWWGRIEPAGA
>NZ_CP044089.1|WP_150348931.1|1982519_1983623_+|ChbG/HpnK-family-deacetylase
MTSERYDEGQQPAHHVGPQRGQAGPFHAGDRDGPMGGGRGASDGNEPGNLSQQAAHVEVVSPLRNQAGDVRCRRIAVCGDDFGMNEAIDGALIELAGAGRLSAVSCMPLAPAFAADAPALARLDVDLGVHVDFTEAFAGAAPAAPGLAALLWRSYAGQLDPDWIDARLASQFDAFERAFGRAPDYVDGHQHVHQLPGILPRLRALLKRRYAGQRIWLRHTAPGLQFGLPLAQAAKARLIGALGAGALARAAGQEGWQTNRRMLGVYDFTGGPRRYAGLLHHWLMNARDGDLLMCHPGWPQVHGAAHASQRAAEYEVLAHPELGTWLARNGLRIVRLSQVRGRQASQESGKVRNVPHSGSFRRLASRL
>NZ_CP044089.1|WP_077274092.1|1982291_1982600_-|GtrA-family-protein
MEWAGLPPLGANVVGWLLAFVVSFTGHFRLTFRHLAASWTIAARRFFLVSALGFAINELSYAWLLHATSLPYDVLLALVLIGLAFLTFVASRLWAFRHRHAP
>NZ_CP044089.1|WP_033461063.1|1980712_1982332_+|glycosyltransferase-family-39-protein
MTLATRSMQPHAVSPGQARSWPLPAAGWLLLAVGVWLAFLSWMRPLALPDEGRYAGVAWDMLRNGSFAVPLIDGMPYFHKPPLYYWLAELSFRLFGVNEWAARLPSALAAWASAVALYLFVRRHRDAASATLCVLVLATLPLFFGGAQYANMDMLVAGMITLCVLAGADTALRARAGQAWRAMALATGVCAALAMLAKGLIGLVLPGAVLLAWLAWRRDWRGLRVLLWPPAILAFAVVAVPWFWLMQVRYPGFFEYFFVHQHFERFAQTGFNNVQPFWFYLPVIAGLALPWSLWAGGLLRKQFWAADADPDGLRRLALVWLAVIVAFFSMPQSKLVGYIMPVLPPLAFLLAEVVMGALRDPAVARATRRMARVSALVAVAICVTAVFVASFNARGSSRELALSLRGELRPDDTLVALHTYPFDLQLYAHAARPMWVVDDWSNPEIPKRDNWRRELYDAVQFEPALGERLLVSADTFQQRLCQAPEGSRYWVWGTAADEEAYAPLRGQAARFADARRSLWLVLVDEAFKGRVCDGTPTGG
>NZ_CP044089.1|WP_003814699.1|1989619_1991743_+|elongation-factor-G
MTRRTSIERYRNIGISAHIDAGKTTTTERILFYTGITHKLGEVHEGAATMDWMEQEQERGITITSAATTAFWRGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYGVPRIAFVNKMDRVGADFFRVQRQIVERLKGDAVPIQIPVGAEDHFEGVVDLVKMKAIIWDDASQGVRFEYRDIPPELQAQAEQWREKMIEKAAEANEALLEKYLSGQPLSEDEIKSGLRARTVANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAIIGHDERDREIERHPADDEPFSALAFKIMTDPFVGQLVFFRVYSGVVKSGDSVLNPLKSKKERLGRILQMHANERREISEVYAGDIAAAVGIKEITTGDTLTDPAHVIILERMTFPEPVISQAVEPRTKADQEKMGIALNRLAQEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGKPQVAYRETIRSTVTDVEGKFVKQSGGRGQYGHVVLKLEPQEQGKGYEFVDAIKGGVVPREFIPAVDRGVRETLNTGVLAGYPVVDVKVTLVFGSYHDVDSNENAFRMAASMAFKEGMRRAKPVLLEPMMHVEVETPEDFTGNVMGDLSSRRGMVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSLTQGRATYSMEFKHYAEAPRQVAEQIIAARGSGAAARG
>NZ_CP044089.1|WP_003820703.1|1991739_1992258_-|MgtC/SapB-family-protein
MDTVWTEIWTTVRNEFADIPDVAEATRIVLRLGMAVALGGLLGYERERSGKAAGLRTHMLVALGAALFVLVPLQGGMEVGDLSRVLQGVIAGIGFLGAGAIIKLGNEGEIRGLTTSAGIWLTAAIGVAAGMGREATALASTLIALFVLAALRRLEKRIAARDDKRVVAQPPP
>NZ_CP044089.1|WP_003814694.1|1992368_1993124_+|TerC-family-protein
MDYLVSLAQQPAAWAALATLIAMEVVLGIDNLIFISILTNKLPPQHQTKARRIGIGMALILRLALLGTVAFIVQLTQPVFELFGHGFSWRDVILVAGGLFLVWKATKEIHHHVDPNPGDDMFGGKAATLGFAAAVAQILMLDLVFSIDSIITAVGMTEHIPIMFVAVIVAVAVMLLAAEPLARFIERNPTVVMLALAFLMMIGMTLIAEGFGAHVPKGYIYAAMAFSALVEGLNMMARRAREGRGAGAAGG
>NZ_CP044089.1|WP_003820704.1|1993320_1994553_+|CoA-transferase
MSGPLEGVRILDVTTVLMGPYATQILGDLGADVIKVEPPAGDNVRGIGPGRHADMGGIFLHANRSKRSIALDLKKPAGREALLKVAATCDVLVYNVRPQAMARLGLSYAEVAQANPSILYVGMYGYDQRGPYAARAAYDDLIQGAVGIPSLSVEAGSDIPRYAPSAMVDRIVGISAANAVTAGLYHRARTGQGQAIDVPMFETMAHLILGDHMMGQTFEPPLGPPGYPRILNADRRPYATRNGHICVLLYADKHWKAFFELIGQPGRDAADPRFRDIGTRTQHIHAIYRLVSDAIASRTTEEWLAAFEAADIPAMPVHTMASLLRDPHLEAIGFFGTVDHPSEGAVRMMAVPSRWSGTPPQPRGHAPRLGEHSVDVLKEAGYDDEAIAALVRDGAAIAAARQRPEGTDHD
>NZ_CP044089.1|WP_033450536.1|1994545_1995331_+|crotonase/enoyl-CoA-hydratase-family-protein
MTDFLRHERHGGVLLLTMDRERTRNALSDADAVEALVQACARIGADLSVRAVVLTGSHGVFSSGGNLKTLSDTVGAGLGEPVHSRQAYRSGIQRIPLALYNLEVPTIAAVNGPAIGAGCDLACMCDIRLAARQASFAESFVKLGLTPGDGGAWLLPRIVGMSRACELAFTGRSIDAARARELGLVSEVFDADALLPAALALAQEIAQHSGHALRLTKRLLREGQHTRLDTLLELSAGFQALAHHTQEHAGALDAYLSRKRD
>NZ_CP044089.1|WP_033472573.1|1995397_1996369_+|tripartite-tricarboxylate-transporter-substrate-binding-protein
MHPRTLALAVLSVAALAQGGSARAASDYPAHPVKIIVSLPPGSGADTTARFLSKHLAERFKQPFVVENRPGANSFIAAQAVATAPPDGYTLFVASNSPMTTNAAVFKNLPYDALKDFAPVAPIARFPMALVVPANSPYRSVADLVAAARAAPGQLNFASGTATYQVVLELFHEQNGIKATHVPYKGTSAALADVAGGVVQYSVADVSAALPLIRGGKLRPLGVTSTRRIKDLPDVPTMQESGNKGFEAYAWTAAFFPAKVDPAIVARVSDAVQALVRSEEGKAFMEQLGGEPFVGGPATLAAFQRDELASMRRIAKLANIQQE
>NZ_CP044089.1|WP_003820707.1|1996379_1997357_-|LysR-family-transcriptional-regulator
MWTGQYIVHIASPAHHWRRAVELRQLKQLLVLSETLNFHRAAERLHMAQPPLSTAIKKLEQELGVQLFERLPAGLQPTPAAEVVLRYARATLFYADEIQRAAQEGASGKQGMLKVGFVGSSVYSLMPQLLSAFRKDYPRVDLVIEESTTVDLLRRLDAHTLDVALVRFPVLEPSTARITLLQADHLMLAVPAGSRYAQRDDVALDELADEPFIGYSRTHVPGMHALVMYAFQQYGVVPHITQEAIQVQTILSLVESGLGLAIVPKVAGRQAGSGVRLVNVPQLAETIKVGIALAVHPDNATPTTANFVDMACRLMQTEPAAGQAR
>NZ_CP044089.1|WP_080605921.1|1997494_1998655_+|acyl-CoA-dehydrogenase
MGTIIEALQLAAIPAHDEALRPAVRAFLDEALREMPADRRARSWMGHDAEFSRALARQGWLGLTLPVEYGGAGRSNFARFVLSEELLAAGAPVSAHWIADRQTAPLILRFGSPAQRAFYLPRIIRGEAFFAIGMSEPDTGSDLASVRTRATPVADGWLLNGRKIWTTNAHRSHYMCALVRTSGAPEDRHRGLSQMIFDLALPGIEIRPIRDMAGDAHFCEVLFDNVLLPHDALVGEEGSGWRQVMAELALERSGPERIYSSMVLLDGWLAHLRRDAAPQRAQVCLAGRLAARLAVLRSMSLAVSQRLEQGADASLAAVLVKDLGTEFEQAVPELIGQALRASPQPAPDDVLMRTLAYLTLINPTFSLRGGTRHILRGIIARELGLR
>NZ_CP044089.1|WP_015041882.1|1998681_1999710_+|acyl-CoA-dehydrogenase
MVSTMQQDLYETFARALAGLCPLERVRELEAAADPRAGAARTWNEVDALGYGDALSPAEHGGAGLSLADAEGLLRAAGAMALPFPFADTLLARALLRAAGQAVPDGPIALGVALPHGADWRCAPIAGVALAQAVAVEHDGCLALWPAPDVVQPGLFRPRASGAPAWRGMPAQAGRAGAPAGAVQAWRNAADAAGMAGAMQAVLDRCVAYVQERQQFGRALGRFQAIQQDISMLAEQVAAVAMAARLACASGALFPDPALAACARLRACEAVPVVCALAHAVHGAIGITEELPLGLYTARLHEWRATGMSEDDCAELLGRRVLADGERTLLDVVRGMVSAAQA
>NZ_CP044089.1|WP_033450541.1|1999776_2000970_+|acetyl-CoA-C-acyltransferase
MSVHPDPVVIVAARRTPIGAFQGALAHYSAPQLGAHALAAAVRQAGLQPDAAQEALMGCCLFAGLGQAPARQAVLGAGLPTDVQATTLSKMCGSGMKAAMLAHDMLRAGSADVVLAGGMESMSNAPHLIPKARQGYRLGDGQLLDHMYRDGLQDAYEGRLMGHYADLAAREYGFSREQQDAYAHESVLRAQRSVAEGEFAEEIAPMAGLARRGAPAAMVAVDETPGLCDVSRLASLKPVFNADGTVTAGNASSISDGAAALVLTRQAHAERLGLAPQARIVGHATAALPPGQFPAAPVRAIARLFERVGWNRDSVDLFEINEAFAVVTMIALRELGLPAERVNVNGGACALGHPVGATGARLIVTLMHALRRRGLRRGVACLCLGGGEATAIAIERA

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Crispr_ID: NZ_CP044089_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_4

2346947-2347028

Orphan

Consensus_repeat	Method
GGCGCCTGTCCCGGCGGGGACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_4

>merge|NZ_CP044089|4|2346947-2347028|CRISPRCasFinder
GGCGCCTGTCCCGGCGGGGACAGACGCCGTCTTGGCAGTGGCGCTCATGGCGCACGACGGGTGCCTGTCCCGGCGGGGACAG

>NZ_CP044089|4|3|2346947-2347028|CRISPRCasFinder
GGCGCCTGTCCCGGCGGGGACAG	ACGCCGTCTTGGCAGTGGCGCTCATGGCGCACGACG
GGTGCCTGTCCCGGCGGGGACAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003814066.1\|2352377_2353265_-\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_CP044089.1\|WP_003814092.1\|2339128_2340028_-\|NAD-kinase	unknown	unknown	gnl\|CDD\|179379
NZ_CP044089.1\|WP_003821186.1\|2345817_2346939_+\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|236757
NZ_CP044089.1\|WP_003814079.1\|2343791_2345717_+\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
NZ_CP044089.1\|WP_003821185.1\|2343320_2343701_+\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP044089.1\|WP_004566468.1\|2350625_2351180_+\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP044089.1\|WP_003814065.1\|2353425_2353779_+\|cytochrome-c	unknown	unknown	gnl\|CDD\|225418
NZ_CP044089.1\|WP_003821189.1\|2351183_2352356_-\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226346
NZ_CP044089.1\|WP_003814083.1\|2342758_2343313_+\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237621
NZ_CP044089.1\|WP_004566476.1\|2337451_2339113_-\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP044089.1\|WP_003821191.1\|2354832_2356089_+\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|180792
NZ_CP044089.1\|WP_003814063.1\|2353791_2354154_+\|cytochrome-c	unknown	unknown	gnl\|CDD\|225418
NZ_CP044089.1\|WP_003814085.1\|2342374_2342617_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_003814061.1\|2354204_2354630_-\|DUF1841-family-protein	unknown	unknown	gnl\|CDD\|370177
NZ_CP044089.1\|WP_150348949.1\|2337070_2337376_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_003821182.1\|2340142_2341147_+\|heat-inducible-transcriptional-repressor-HrcA	unknown	unknown	gnl\|CDD\|234621
NZ_CP044089.1\|WP_003821193.1\|2356287_2357268_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340821
NZ_CP044089.1\|WP_004566474.1\|2341204_2342293_+\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
NZ_CP044089.1\|WP_003814072.1\|2350213_2350588_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_003821187.1\|2347129_2349880_-\|insulinase-family-protein	unknown	unknown	gnl\|CDD\|223685

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_003814066.1\|2352377_2353265_-\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.30038e-45
NZ_CP044089.1\|WP_003814092.1\|2339128_2340028_-\|NAD-kinase	gnl\|CDD\|179379	PRK02155, ppnK, NAD kinase.	0
NZ_CP044089.1\|WP_003821186.1\|2345817_2346939_+\|molecular-chaperone-DnaJ	gnl\|CDD\|236757	PRK10767, PRK10767, chaperone protein DnaJ; Provisional.	0
NZ_CP044089.1\|WP_003814079.1\|2343791_2345717_+\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
NZ_CP044089.1\|WP_003821185.1\|2343320_2343701_+\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.07863e-05
NZ_CP044089.1\|WP_003814065.1\|2353425_2353779_+\|cytochrome-c	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	6.05638e-23
NZ_CP044089.1\|WP_003821189.1\|2351183_2352356_-\|VWA-domain-containing-protein	gnl\|CDD\|226346	COG3825, COG3825, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_CP044089.1\|WP_003814083.1\|2342758_2343313_+\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237621	PRK14139, PRK14139, heat shock protein GrpE; Provisional.	1.18525e-78
NZ_CP044089.1\|WP_004566476.1\|2337451_2339113_-\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0
NZ_CP044089.1\|WP_003821187.1\|2347129_2349880_-\|insulinase-family-protein	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	3.06874e-64
NZ_CP044089.1\|WP_003814063.1\|2353791_2354154_+\|cytochrome-c	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	2.60442e-23
NZ_CP044089.1\|WP_003814061.1\|2354204_2354630_-\|DUF1841-family-protein	gnl\|CDD\|370177	pfam08897, DUF1841, Domain of unknown function (DUF1841). This family of proteins are functionally uncharacterized.	2.9417e-76
NZ_CP044089.1\|WP_003821182.1\|2340142_2341147_+\|heat-inducible-transcriptional-repressor-HrcA	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	5.93958e-145
NZ_CP044089.1\|WP_003821193.1\|2356287_2357268_+\|hypothetical-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	3.29499e-14
NZ_CP044089.1\|WP_004566474.1\|2341204_2342293_+\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	3.4326e-159
NZ_CP044089.1\|WP_003821191.1\|2354832_2356089_+\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
NZ_CP044089.1\|WP_004566468.1\|2350625_2351180_+\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	1.87052e-61

>NZ_CP044089.1|WP_003821186.1|2345817_2346939_+|molecular-chaperone-DnaJ
MAKRDYYEVLGVAKNASDEDLKKAYRKLAMKYHPDRNPDSKEAEEKFKEAKEAYEVLGDEQKRAAYDRYGHAGVDPNAAGMGGGMGGGFADAFGDIFGEIFGAGRRGGGGPQVYRGADLKYALEITLEQAASGFDTEIRVPSWENCDTCHGSGAKAGTSPKTCRTCGGSGAVRMQQGFFSVQQTCPTCHGTGKEITDPCPSCDGVGRTRRNKTLQVKIPAGIDDGMRIRSSGNGEPGINGGPPGDLYVEIHIKQHKIFQRDGDDLHCELTIPFTTAALGGELQVPTLGGKAEISIPEGTQSGKTFRLRAKGIRGVRGSYPGDLYCHVVVETPVRLSDEQKAILRQFEASLNDGGDRHSPQSKSWTDRVKEFFS
>NZ_CP044089.1|WP_003814079.1|2343791_2345717_+|molecular-chaperone-DnaK
MSKIIGIDLGTTNSCVAVLDGGQVKIIENAEGARTTPSIVAYMDDGETLVGAPAKRQAVTNPKNTLYAVKRLIGRKFDEKAVQKDIDLMPYSIVKADNGDAWVEVRGKKLAPPQVSAEVLRKMKKTAEDYLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKTEKGDRKIVVYDLGGGTFDVSIIEIADVDGEMQFEVLSTNGDTFLGGEDFDQRIIDYIISEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSSQQTEINLPYITADASGPKHLNLKITRAKLEALVEELIERTIEPCRVAIKDAGVKVSDIDDVILVGGMTRMPKVQDKVKEFFGREPRKDVNPDEAVAAGAAIQGSVLSGERKDVLLLDVTPLSLGIETLGGVMTKMIQKNTTIPTRYSQTFSTADDNQPAVTIKVFQGEREIAAGNKGLGEFNLEGIPPAPRGLPQIEVTFDIDANGILHVSAKDKGTGKENKITIKANSGLSEDEIQRMVKDAEANAEEDHRLAELAQARNQADALVHATRKSLTEYGEKLEAAEKESIEAAIKDLEDILKTGDKAEIDAKVEALSTASQKLGEKMYADMQAQQQAQQQQAADNAKPVDDNVVDADFKEVKRDQ
>NZ_CP044089.1|WP_003821185.1|2343320_2343701_+|thioredoxin-family-protein
MAAAPFDPAEVFQVFGMRRVDSASFDEQVVQAPGDDLRCVFLWGQDCYNCGIFKQTALLQRQALLALELSWFEADVYADEALGRRFSLHGVPTFVLYRSGKRLGRVTGWPGLPQFSAAMQRLRDGT
>NZ_CP044089.1|WP_003814083.1|2342758_2343313_+|nucleotide-exchange-factor-GrpE
MTAPQEPVDSTPESGENAATPGLEDDLSAELAALRAELEAAQATVKAQQEQVLRAAAEAENVRRRAQEDVAKARKFGIESFAESLVPVKDSLEAALAQPDQAAQAWREGVEVTLKQLTAAFERNLLKEIAPAQGDKFDPHLHQAISSVPADQPANTVLQLLQKGYVIADRTLRPALVVVSAGQG
>NZ_CP044089.1|WP_003814085.1|2342374_2342617_+|hypothetical-protein
MNPPRKPTIGTSGPPGHANLEEDQLERELDEALLETFPASDPIAITSEDERDEPDDKVDEALEDTFPASDPPAPAQPGKK
>NZ_CP044089.1|WP_004566474.1|2341204_2342293_+|ferrochelatase
MFLRLFKYLWPERYLPETPAQDPFDENPPPCGPGRVGVLLVNLGTPDEPTRGAIRQYLGEFLSDPRVIEIPRYLWMPILHGLVLTMRPKKLAPRYAGIWMEEGSPLLVYSQRQAAGVRQGLAARGVHAEVELAMRYGKPSIPAAIAALRERGCDHILAVPLYPQYAASTTATVVDAVTRHAGRLRDQPALRFVKRFHNDPAYVEAQAGRIAEFWQAHGRPQKLVMSFHGLPRYSIELGDPYYRDCLDTARLLRERLGLREDEVEVTFQSRFGSARWLEPYTEPTLAELARQGVTEVDVVCPGFVADCLETLEEISQECRDAFVAAGGRQFRYIPALNDCPPWIEGLTDLVERQLRGWPTGNP
>NZ_CP044089.1|WP_003821182.1|2340142_2341147_+|heat-inducible-transcriptional-repressor-HrcA
MDDRARALLKALIERYIADGQPVGSRTLSKVFDLSPATIRNVMADLEELGLIHSPHTSAGRVPTPRGYRMFVDSLLAVRAYQFEPAHIGELLPVSEPSRAVNAAAALLSNLTQFAGVVLTPKRTQIFRQIEFIRLSDKRVLLIIVTPEGDVQNRILSAQRDYTEAELLEAGNFFNVHFSGKSFDAVRRTLSTELAQLRDDISRLMQAAVEAGAEAADDGEAVVISGERKLLDVTDIASDMDRLRKMFSLFEKKTDLLQLLDVSSRAQGVQIYIGGDSQLVPMEEVSVITAPYGLDGKVIGTLGVIGPTRMAYERVIPIVDITARLLSNALSHNQ
>NZ_CP044089.1|WP_003814092.1|2339128_2340028_-|NAD-kinase
MYFPIVALIGRYQDTGLDAPLTALAQMLTQAGRRVLVEAETARNAGVSGYPVADWDEIGRTATLAVVMGGDGTVLGAARHLAPYGVPLIGINHGRLGFITDIPLQDAHDALGRVLEGNYQAEDRMLLQGGVWRGEQQMYSASAVNDVVLNRAGRGGMIEVRVELDGAFMYTQRADGLIIATPTGSTAYSLSANGPILHPGMNAMVLVPVAPQTLSNRPIVIPDSGVLNMTLTAMGRVEIGASVHFDMQTWSDLQPGDRITVQRAPHTIRFVHPEGYSFFSTLRRKLHWNLMPQATDNLE
>NZ_CP044089.1|WP_004566476.1|2337451_2339113_-|DNA-repair-protein-RecN
MLRTLHIRDFVIVEQTELHFGDGFTVFSGETGAGKSILIDALALTLGERGDASMLREGAARADITAVFDAPPALRDWLAERELDSGDELALRRVIDSQGRSRAYINGMPATIAQLRELGDGLVDIHGQHAHQSLMRPDAQRDLLDAHGGHAELRQTVAQAWKQWRALARQLDTAEQDAEALAAERDRLQWQSDELDRLGLGPDEWDALQTEHTRLSHAQSLLDGASRILEALDGEHDSAQHRLNGAAHQLQQMLRHDPALQGIGDELESARIAITEAVSDLNNYVSRVELDPQRLADVEARLSAVFETARKFKCEPHDLPALRDSLHGKLAEMQAASDVQALRAQAEAAQARYEAAAARLSAARRKIAKDLGKQVTQAMQTLSMQGGRFEAALTGGAPSAHGSEQVEFLVAGHAGSTPRPLAKVASGGELSRISLALSVIASRAARVPTLIFDEVDSGVGGAVAEAVGKLLRELGQRHQVLCVTHLPQVAACAHAQYRVSKVESGGSTRSRIAELDAEARVEEVARMLGGIKITATTRDHAREMLGGHTAPAA
>NZ_CP044089.1|WP_150348949.1|2337070_2337376_-|hypothetical-protein
MGRPGGRKCPHAALAARACCPPRGLFCLGAARRQKMPPRCARCAGLLPPKGALLPWGGPAVENAPTLRSLCELAAPQGGFLPWGGPAAKKNLQACAWRQGW
>NZ_CP044089.1|WP_003821187.1|2347129_2349880_-|insulinase-family-protein
MRLPLLSRRLNALLVSSFLAFQAGAASLPAGVSEVSSIEGITEYRLANGLRVLLAPDASKPTTTVNMTYLVGSRNENYGQTGMAHLLEHMLFKGTPAIRNALGEFSRRGLQANGSTSSDRTNYFASFAANPETLKWYLGWQADAMVNSLIAKEDLDSEMTVVRNEMESGENNPFRVLMQKMQAAAYQWHNYGKSTIGARSDVENVDIAQLRAFYHEYYQPDNAVLIVAGKFDPQTALADIQSSLGKLPKPKRTLPPEYTVEPVQDGERSVTLRRAGGTPLVAAMYHLPAAGSPDFVGLDLAATILADTPSGRLYHALVPTKLASGVFGFTMDQLDPGLAMFGAQLQPGMDQDKALQTLTATLESLSSKPFSQEELERARSKWLTAWQQTYADPEKVGVALSEAIASGDWRLFFLQRDRVRDAKLDDVQRAAVAYLVRSNRTEGRYIPTEKPQRAPLAQRADLAAVFKDYKGDPNFKAVEAFDPSPANIDKRTLRRTLDLPNGQVELALLPKATRGDRVQAELLIQFGDAEALRGQRVPLAAAAALLDRGTDKLSRQAIQDRLDQLQAEAAINGSGTNLVVNISTLGKNLPDVMALVLDVVRNASFPQDQVEEYKRQAITMVQDAMTDPTALASRALARHNNPWPADDVRYVPTFDEALEQLRSLSRDDLAAVSGKLYGAGRIKFSAVGEFDPAAVEAVLRKGLDGWRSAPAYTRLPDPYRAVPAQQFDIATPDKANAFYISRMPLQLQDTNADYPALYLANFLLGTSETSRLWHRVRETEGLSYNVRSNLSVSSYEPSANWTIYAIYAPQNRARLEKAISEELARALKDGFTDQEVRDGVVALLNYRNLARAQDDVLADTWVNYMQTGRSFQWSADMDRKLEALTPDQVNAALRKYLKPDAFSTAVAGDFTKKSAP
>NZ_CP044089.1|WP_003814072.1|2350213_2350588_+|hypothetical-protein
MLTDIVTRALSQLLGNSLSGDVIKGRFRYAYASDDGRFVAILGHDLTTYVVDVDAQRYFAECAGVPCGFAGHVLEMEGAQEHGHPWPAVNDLFDLDMDGDEIAWRRCPGAVALAATRQAQSRVA
>NZ_CP044089.1|WP_004566468.1|2350625_2351180_+|N-acetyltransferase
MNATPSPAPTGATLVDCTHDRHAAAILDIFNDAILTSTALYDYQPRALASMEAWFQAKRQGGFPVVGFEDAAGVLMGFASYGTFRAWPAYKYSVEHSVYVDRRYRGRGLGEALLRALIERARLQQVHVLVGGIDATNAGSVALHRKLGFVHAGTITQAGFKFGRWLDLAFYQLTLDTPLRPVDG
>NZ_CP044089.1|WP_003821189.1|2351183_2352356_-|VWA-domain-containing-protein
MLIDFFYHLRAHKLPVSVQEYLTLLEALRQRLMAPTLDDFYFLARTALVKDESLYDRYDAAFGAYYRGIAAALPADRDIPLDWLIKEFEKTLTPEEKAAIEAHGWDKLMELFKQRLEEQQERHAGGSKWIGTGGTSPFGNGGYHPEGIRVGGDSAGNRTAVKVWDMRQFRDYDDQLELGTRNFKVALRRLRRFARQGADLELDLDDTIASTARNAGHLDLRLVPERRNTVKVLMLLDVGGSMDDHIARVEELFSAARSEFRHLDVYYFHNCPYENLWQNNRRRQNERFDTWDVLRKYNADWRLIIVGDATMSPYEILQPGGSVEHYNKEAGAVWLRRLLDAWPKAAWLNPEPTASWRYRQSIALLRDIMQDRMYPVTVAGLEQAMRQLSK
>NZ_CP044089.1|WP_003814066.1|2352377_2353265_-|MoxR-family-ATPase
MPTSASSSSAPAQSARFEGTDRYVATDDLKLAVNAALTLQRPLLIKGEPGTGKTMLAEEVARALDRPLLQWHIKSTTKAHQGLYEYDAVSRLRDSQLGDEKVRDIRNYIVQGTLWQAFEAPEPVVLLIDEIDKADIEFPNDLLRELDRMEFHVYETRQTVQARHRPLVIITSNNEKDLPDAFLRRCFFHYIRFPDRDTMRDIVGVHYPDIRQDVLRAALDTFFALREAPGLKKKPSTSELLDWLRLLLAEAIPAAEIDAHAATAVPVLAGALLKNEQDVHLLERLGAMARGAQRR
>NZ_CP044089.1|WP_003814065.1|2353425_2353779_+|cytochrome-c
MKLRISMTRTVSVLAVLASCAIAGPAAAADAAPVGNAQNARDKVSMCIGCHGIPGYKASFPELYHVPMIAGQNAKYIEAALNEYRKGARSHPTMDAVAGSLSDQDIADLAAYYSSLK
>NZ_CP044089.1|WP_003814063.1|2353791_2354154_+|cytochrome-c
MKRFTFALAGIVLATAGVSAQAQDVVAGKAVFDKFNCASCHGADAKTSVQPEYPVLAGQHADYLAHALKAYKRGAAGSAATANVRKNPIMGAFAAQLSDQDIRNVAAWLAAQPSDLGVRQ
>NZ_CP044089.1|WP_003814061.1|2354204_2354630_-|DUF1841-family-protein
MFNPSRDQVREFFIETWRKHRATEVLTPLESMALDWILEHPEYHGDLESPEAMTAEYPVEHGRTNPFLHLSMHLAIAEQLSIDHPRGIRAAYQRLVGRGDAHQAAHEIMECLGQVVWEAQRLGTPLDSDAYIELIRQRAER
>NZ_CP044089.1|WP_003821191.1|2354832_2356089_+|NADP-dependent-isocitrate-dehydrogenase
MSYQHIKVPTGGQKITVNADYSLNVPDQVIIPVIEGDGTGADITPVMIKVVDAAVQKAYAGKRKIHWMEVYAGEKATKVYGPDVWLPEETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIYAGIEYMAESEQAKDLIQYLQTKLGATKIRFPNTSSIGIKPVSREGTERLVRKALQYAIDNDRASVTLVHKGNIMKFTEGGFRDWGYALAQNEFGAQPIDGGPWCKFKNPKTGREIIVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
>NZ_CP044089.1|WP_003821193.1|2356287_2357268_+|hypothetical-protein
MAKPASDMPPYDKADALRGLAGARRVALLMAPRLGDTLLMMNMARNLAAHGREVSIFGDYIHGLRDWFPGLDIRPSLSEEQAGQVLPGYDCAAQMHVGWPYALHAHQPNYFYYDAHVVITGRGFVKLFQIRDFCREQLGLAQAGADNGLRPPPQVQPHRSHPRRVALHPTSTGAQRCWAPRHFKELGLRLLHEGYEPNYIVAPHERAEWSWVLDHGLHLPQFPSLSEVAGFIHASGWFIGNESGIGHLASNVGVPTLSLTGRPTRTRAWRPAWSTSRIVYPALIPGGRWRDRLWREWLSPRRVMSAFHKLQADDRRQPVGVPWGKI

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Crispr_ID: NZ_CP044089_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_5

3424844-3424927

Orphan

Consensus_repeat	Method
GGTGCCTGTCCCGGCGGGGACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_5

>merge|NZ_CP044089|5|3424844-3424927|CRISPRCasFinder
GGTGCCTGTCCCGGCGGGGACAGATACCGTCTTGGCCGTCGCGTCGATGGCGTACGGCAGTGTGCCTGTCCCGGCGGGGACAGG

>NZ_CP044089|5|4|3424844-3424927|CRISPRCasFinder
GGTGCCTGTCCCGGCGGGGACAG	ATACCGTCTTGGCCGTCGCGTCGATGGCGTACGGCAG
TGTGCCTGTCCCGGCGGGGACAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003812173.1\|3425098_3426451_-\|glutathione-disulfide-reductase	unknown	unknown	gnl\|CDD\|235701
NZ_CP044089.1\|WP_003817016.1\|3433076_3434459_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240536
NZ_CP044089.1\|WP_033448458.1\|3420912_3421818_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176160
NZ_CP044089.1\|WP_003817006.1\|3427364_3428060_+\|thiol:disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|172475
NZ_CP044089.1\|WP_003817003.1\|3426625_3426922_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_015041587.1\|3414731_3415556_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP044089.1\|WP_003817001.1\|3424128_3424773_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP044089.1\|WP_003817015.1\|3431784_3433047_-\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|237248
NZ_CP044089.1\|WP_003817010.1\|3429628_3430339_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP044089.1\|WP_003812166.1\|3431394_3431730_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP044089.1\|WP_003812180.1\|3419795_3420254_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP044089.1\|WP_033448484.1\|3421903_3422917_+\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|226105
NZ_CP044089.1\|WP_003816993.1\|3415507_3416482_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
NZ_CP044089.1\|WP_015041586.1\|3417568_3419782_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NZ_CP044089.1\|WP_033448463.1\|3426946_3427324_+\|DUF2784-domain-containing-protein	unknown	unknown	gnl\|CDD\|378502
NZ_CP044089.1\|WP_015041582.1\|3428070_3429552_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP044089.1\|WP_003812179.1\|3420411_3420756_-\|exported-protein	unknown	unknown	gnl\|CDD\|288556
NZ_CP044089.1\|WP_050460974.1\|3416510_3417572_-\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|224886
NZ_CP044089.1\|WP_003817012.1\|3430465_3431392_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP044089.1\|WP_150349045.1\|3422924_3424043_-\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|237190

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_003812173.1\|3425098_3426451_-\|glutathione-disulfide-reductase	gnl\|CDD\|235701	PRK06116, PRK06116, glutathione reductase; Validated.	0
NZ_CP044089.1\|WP_003817016.1\|3433076_3434459_-\|MATE-family-efflux-transporter	gnl\|CDD\|240536	cd13131, MATE_NorM_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.	1.49385e-159
NZ_CP044089.1\|WP_033448458.1\|3420912_3421818_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176160	cd08471, PBP2_CrgA_like_2, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 2. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.9221e-98
NZ_CP044089.1\|WP_003817006.1\|3427364_3428060_+\|thiol:disulfide-oxidoreductase	gnl\|CDD\|172475	PRK13972, PRK13972, GSH-dependent disulfide bond oxidoreductase; Provisional.	9.78766e-82
NZ_CP044089.1\|WP_015041587.1\|3414731_3415556_+\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	3.93278e-06
NZ_CP044089.1\|WP_003817001.1\|3424128_3424773_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.64027e-44
NZ_CP044089.1\|WP_003817015.1\|3431784_3433047_-\|Zn-dependent-hydrolase	gnl\|CDD\|237248	PRK12890, PRK12890, allantoate amidohydrolase; Reviewed.	0
NZ_CP044089.1\|WP_003817010.1\|3429628_3430339_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.47026e-25
NZ_CP044089.1\|WP_003812166.1\|3431394_3431730_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.67695e-05
NZ_CP044089.1\|WP_003812180.1\|3419795_3420254_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	8.69353e-72
NZ_CP044089.1\|WP_033448484.1\|3421903_3422917_+\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|226105	COG3576, COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only].	5.56942e-18
NZ_CP044089.1\|WP_003816993.1\|3415507_3416482_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	1.08848e-65
NZ_CP044089.1\|WP_015041586.1\|3417568_3419782_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	1.17929e-123
NZ_CP044089.1\|WP_033448463.1\|3426946_3427324_+\|DUF2784-domain-containing-protein	gnl\|CDD\|378502	pfam10861, DUF2784, Protein of Unknown function (DUF2784). This is a family of uncharacterized protein. The function is not known however it is conserved in Bacteria.	5.8699e-36
NZ_CP044089.1\|WP_015041582.1\|3428070_3429552_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	7.14269e-131
NZ_CP044089.1\|WP_003812179.1\|3420411_3420756_-\|exported-protein	gnl\|CDD\|288556	pfam11720, Inhibitor_I78, Peptidase inhibitor I78 family. This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78.	2.38824e-32
NZ_CP044089.1\|WP_050460974.1\|3416510_3417572_-\|XdhC-family-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	6.06922e-58
NZ_CP044089.1\|WP_003817012.1\|3430465_3431392_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	9.6581e-14
NZ_CP044089.1\|WP_150349045.1\|3422924_3424043_-\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|237190	PRK12755, PRK12755, phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional.	0

>NZ_CP044089.1|WP_003817001.1|3424128_3424773_-|LysE-family-translocator
MRATMPEPTQLLAFALICLGMTLTPGPNMMYLVSRSLSQGYRAGLVSLAGVALGLVFYVLCAVLGITALLMAVPLAYEALCVAGAIYLMYMAWQALRPGGQSPFQVRALAPSPPRRLFAMGLFTALLNPKIAVLYLSLLPQFIDPQQGSVLTQSLALGFTQVGISICVNALFTVMAGAIAVFLARRPMWMVAQRWLMGSVLAGLAVRMALDARR
>NZ_CP044089.1|WP_150349045.1|3422924_3424043_-|3-deoxy-7-phosphoheptulonate-synthase
MTRIDDPLHDREAGQADATQDTTRIDDVRIGAVRPLISPALLQDELPVSAPLQALVEDSRARIADVLHGRDDRLVVVVGPCSIHDHEQAMEYARQLKEAADTLADDLLIVMRVYFEKPRTTVGWKGYINDPRLDGSFRINEGLRRARHLLLEIGALGLPIATEFLDLLSPQYIADLIAWGAIGARTTESPSHRQLASGLSCPLGFKNGTDGGIQVAADAIVAASAPHAFMGMTKMGTAAIFETRGNDDTHVILRGGKQGPNYDAAAIDACCAALARAGLREQVMVDCSHANSNKSHARQVDVARDLARQLAGGDRRIIGIMIESNLEEGRQDLKPGVPLKRGVSITDACLSWAQTEPVLAELAQAVRQRREG
>NZ_CP044089.1|WP_033448484.1|3421903_3422917_+|pyridoxamine-5'-phosphate-oxidase
MAVVRYDIPGALMSDSLVFHTDLPGLADGPWHGGELAMQERAGARERMAQLGPRVIRDHMPQQHRDFFAQLPFMLLATVDAQGDPWASVLEGPPGFAHSPDERTLRLDALPAGDDPARAGLAHGAGVGMLGIELSTRRRNRVNGHVAALDGQGFCVAVTQSFGNCPQYIQTRHARQTAPAPQPARWLAGLDAAARTLVGQADTLFVASYARQAGPHAVDVSHRGGPPGFVHLRGDTLTMPDFSGNRFFNTLGNLLANPRAGLVFVDFARGDLLQLCGRAEVLAEAGAPAAYPGAQRLWRVHVERAVRRPAALGLRAGFGEYAAQLAAVGQWAGEPPA
>NZ_CP044089.1|WP_033448458.1|3420912_3421818_+|LysR-family-transcriptional-regulator
MDKFQEVSLFLAVAEARSFAAAGRRLGLSASTVTRAVAALEARLGILLLVRTTRHVRLTDAGEQFAHDCRAVLDNLAQAEEAAAGGRVQPRGELSVTAPALFGELHVMPAIVDYLRQHRQVRLRALLVDRVVRLLDEGVDVAVRIGRLPDSSLTAIHVGDVRRIVCAAPDFLARAGVPSHPDMLPRYCTVSVVMEGQMDRWRFVCDGHARDLDVQAQLTVTSSQAAVRAAVQGWGLAQVVSYQAAGALREGALQVVLREFEPPPLPVHVVYPEGRKGAAKVRSFVEFCVERLRAELAGLPA
>NZ_CP044089.1|WP_003812179.1|3420411_3420756_-|exported-protein
MIWKLIPIALLAGLTACASGTRTDSSPPASSQTSSSAAPGSATTPSGPDCDAQPVQNLVGQKYSDSVGNDALRRSNSGSMRLLKPGQVMTMEYNARRLNIILEGNGSISALRCG
>NZ_CP044089.1|WP_003812180.1|3419795_3420254_-|(2Fe-2S)-binding-protein
MPTLNINGKDTVLDAPGEMPLLWALRDVADLTGTKYGCGMALCGACTVHADGQPIRACITPVQAVAGRRIVTIEGVAADRAGQAVQQAWRELDVAQCGYCQSGQIMSAAALLRANPAPTDRDIDDAMNGNICRCATYVRIRAAIHAAAAALA
>NZ_CP044089.1|WP_015041586.1|3417568_3419782_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MRIAIQNLSRRRFVQGAGGLLLGLSLPPLARRAMAAGPQAGDGFAANAFVRIGADGRVTVLAKHLEMGQGAYTGLATLLAEELDADWRQVRVEGAPADSARYGNQALGGLQGTGGSTAMFDSWEPMRRAGATARAMLVQAAAQRWQVPADTIEVAEGVLSHPASGRRAGFGELAEAAARSPVPQDVPLKDPARFRLIGKHRLPRVDSAAKSDGSALYTQDMKLPGMLVAVVAHAPRLGAAVARVDDAAARAVPGVRAVVRFGGAPLRHAGVAVLATNTWAARAGRDALRIEWDEGPAYRQGSADILARYREAVGRPGSMAARKGDIDAAFAGAAKVIEAEYTYPYLAHAAMEPLNCLVRLDDERCEIWNGEQFQTADQRAIAQYLGMPAERITLTQLYAGGSFGRRASSHADYLLEAVAIARTARAQGLNAPVKLVWMREEDMRAGYYRPLNLHRARLALGADGALQAVHVRMAGQSILLGTPLADWVRDGVDPVSVEGLSDLAYAVPNLQVELHTPTDVPVPVLWYRSVGHTHTAFSAETLIDEAAVAAGQDPVAYRLALLAAHPRHREVLQLAAARAGWREPLAAGAPGTRRGRGVAVHESFRSVVAQVVEVTIAADGALKVDRVVCAVHCGLAVNPDVVRAQMEGGIGFALSTALHGAITLKDGAVEQSNFHDYPVLRLAEMPAVEVHIAPSTQPPTGVGEPGVPPLAPALANAIAQATGQRLRTLPLGTTVKA
>NZ_CP044089.1|WP_050460974.1|3416510_3417572_-|XdhC-family-protein
MRSIAMQAADLYVLQTAQSWLDAGQAAVLLTVARTWGSSPRPPGAMMAIRADGAVAGSVSGGCIEDDLIDQIRQRGIAALCPGARPALATYGVDGEQARRFGLPCGGTLQLVLEPLGAHSRLEDLLARLRARQTVRRSVRLADGAVTLEPAAADAEPRLDGAGFASVLGPRHRLLVVGAGQLSRYLCEMAVALDFDVTVSDPREEYRAGWQVEGVALTTAMPDDMVIAARPDARTAVIALTHDPKLDDLALIDALQTPAFYVGALGSRANHARRVARLREHFGLTAAQLARLRGPAGIYIGSRTPPEIALSIMAEIVAGKNGAPLPPAASVAAGKARQPGSAGVIQAGLCATL
>NZ_CP044089.1|WP_003816993.1|3415507_3416482_-|AraC-family-transcriptional-regulator
MSALPDSPSASPPPRHDELASLIERHTPADGTTATALPGLNFYRSSSPTELNVSFYRPSLALLAQGAKRVQLGDDVYEYDTSHYLLTSFDLPVASRVTLATPGTPYLCFALDLDPHRIAGLISELGAPPAGQPLRRGLTLARLTEPLLDAVLRLARLLDTPADIPVLAPLIEREIHYRLLSGPMGGRLRHIARAEGTALQIARAIDWLRRHYAQPLRVEHLATTVNMSVSSLHHHFKAVTALSPLQYQKQLRLHEARRLMVAETLDAGAAAHRVGYESASQFSREYSRLYGAPPLRDAARLRGTAPADAQSPGLARASASATVS
>NZ_CP044089.1|WP_015041587.1|3414731_3415556_+|hypothetical-protein
MTGTMTIRIDEELRAYIDPLTPDEYAALEQSLLAEGCRDALVLWGDLLVDGHNRHAICSKHGIAFNTVQNTRLQSMDDVRLWMIDNHLGRRSVSDFQRGVLALRKKEILESRRQAGEGDAAPAGSDGPAPAPLTRQTLARQARLSSTTLGQIEKIRQQAAPELVRAVQSGEISINAAAAVATLPAPQQAAAAAGGRGELRAAARQVREARLPVRRAPEAEPAPAAEPRVVDDYPAEVARLDRLVAQLAEERDALKKKVVQLTVALAEARAKPGD
>NZ_CP044089.1|WP_003812173.1|3425098_3426451_-|glutathione-disulfide-reductase
MAFDFDLYVIGAGSGGVRAARFAAGYGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFHEDFEQAAGFGWNPGRPEFDWPTLIANKNREIERLNGIYRNLLVNSGVALHEGHARIVDPHTVEINGQRHSAQHILVATGGWPFVPDIPGKEHAITSNDAFFLPELPRRVLVVGGGYIAVEFASIFNGLGAQTVQVYRRELFLRGFDGSVREHLRDELVKKGLDLRFNTDVERIDKRADGVLAVTLSDGSVLETDCVFYATGRRAMLDDLGLENTGVRLAESGYIEVDDEYRTSEPSILAIGDVIGRVPLTPVALAEGMAVARRLFRPQEYRKVDYDLIPTAVFSLPNIGTVGLTTEQALERGFRVTRYESRFRPMKLTLTQSQEKTLMKLVVDADSQKVLGCHMVGPDAGEIVQGLAVALKAGATKQVFDDTIGIHPTAAEEFVTMRTAT
>NZ_CP044089.1|WP_003817003.1|3426625_3426922_+|hypothetical-protein
MQNEDSFFGSLGAILGAVIRAIVDGLRYVFGGLGRALGDFFGGLASALGMSPSVFNFALLVLGLLLLWTAVRAFMGRAIVAGIFWLVLAMLLLGGLIG
>NZ_CP044089.1|WP_033448463.1|3426946_3427324_+|DUF2784-domain-containing-protein
MLYRFLADLVLALHALFVAFVVLGGLLALRWPRLAWLHVPAALWGAGIMLAGAICPLTPLENHWRAQAGQQGYEDGFIAHYLLAAIYPEGLSRTAQTVLGGLALAGNALVYAALWRRRRRGGIGR
>NZ_CP044089.1|WP_003817006.1|3427364_3428060_+|thiol:disulfide-oxidoreductase
MIDLYFWATPNGLKIKLFLEEAGLPYTEHPINIGKGEQFQREFLAIAPNNRIPAIVDQAPAGGGAPISLFESGAILLYLAEKIGRFIPADVRGRAEVLQWLFWQMGGLGPMAGQNGHFNVYAPEKVPYAIERYTAETARLYDVMDRRLAEREFLAGEYSIADIACYPWVVPHEAHGQKMAHFPHLSRWFEAIAARPATARAYKEAGDSYRPKAPMSDEERTVLFGQPGAPR
>NZ_CP044089.1|WP_015041582.1|3428070_3429552_-|PLP-dependent-aminotransferase-family-protein
MIKSATNRLFDRAMDFAAILQQAPQAGARLPLQRQLLQRFKNAILDGRLAPGSRLPASRALAQQLGISRNTVLLAYEHLAAEGYVRADRQGTRVAGLARAGMPARASAASSAGPTARRLAALKASAPRTDTYLPLRPGTPALNHFPASAWRNALERALREAPAALLGYGEPAGEPRLRQAIAAYLAAARGVRCEARQIVITEGAQEGLALCVRLLGNAGDTAWVEDPGYRGAKTALRCGDMRVVPVRVDAAGLLAPPQAWRDAPPRLIYVTPSHQYPTGAVLPVTRRLALIEQARRAGAWIIEDDYDSEFRHQGEPIAAMQGLVPDAPVLYVGTYSKTMFPSLRLGFVVLPTGLADEAAEALAEMLRGGHRHEQWALASFIESGQFTRHLNRMRRLYRERQQALRAALARHLRVPHEVLGGHCGLHLTLRLPAALDDRAIAAQALRLGMAPQALSGFAIAPRPEDTGLVLGYGNTSAELFEPLIERLARLIQA
>NZ_CP044089.1|WP_003817010.1|3429628_3430339_+|GNAT-family-N-acetyltransferase
MPARVNEFGQPIGQAMPQWQARPRPPRDPAEGRYCRLEPLDAARHGEDLYAAFAVPDAASGWTYLSAGPFADRAGYDEYLRKAADSADPLHHAVIDLASGRAIGTLSLMRIDPANGVIEVGHVNFAPALRRSPASTEAQYLLMRRAFDELGYRRYEWKCDSLNAPSRAAALRLGFLFEGIFRQALVYKGRTRDTAWFSIIDSEWPALRAAFERWLAPENFDAAGRQRKRLDACRQP
>NZ_CP044089.1|WP_003817012.1|3430465_3431392_-|DMT-family-transporter
MAAAAPLRRPLDGFATYVMLALCICWGFQQIAIKLVAADVSPTLQIGLRSAFAAVVLIWVVLRHEGLGAFRDGTLGPGLAVGALFALEFLLVGVGLDYTTASHMAVFLYTAPIFTALGLHLLLPDERLKPLQWLGVAVAFGGIATAFLGKGHASVPGMLLGDLLGVLAGAAWGATTVAIRKSSLSEAAPAKTLFYQMLMAGLALPAFHFASGGAAPVWSGAALASLGFQSVVVALSSYLAWFWLLRRYLATRLAVLSFMTPLFGVTFGVLILDEPLDSGFVIGAVLVLAGITLVSGAELLREKLRRRT
>NZ_CP044089.1|WP_003812166.1|3431394_3431730_-|thioredoxin-family-protein
MDQIELTDGTADRYLLDAPGLSLLVFHSRTCATCGVARQRLPEFDLPVDRLCWIDAGENGGLVQRYEVFHLPALFVTRDGAYYGPVSAQLADWDLRQQISLALDSYPAELP
>NZ_CP044089.1|WP_003817015.1|3431784_3433047_-|Zn-dependent-hydrolase
MTTTFPPLNADRLWSRVETLSRMTLPDVPWTRRAFSPLFEQSRQWLRAEFEAAGLAVRLDAGGNLVGTRPGRDAARRPIATGSHCDTVMAGGRFDGIIGVLAGIEVAHTLHEQGVTLEHPFDVIDFLSEEPSDYGISCVGSRALSGQLTPDMLAARNADGETLAEGLRRIGGDPDALGAPLRGPGQTAAFVELHIEQGPVLESRGLPIGVVTNIVGIRRVLITVHGQPDHAGTTPMDIRRDALVGAARVIDAAHRRASAQSGKPHYVVATIGRIAMTPNAPNAVPGMVELMLEVRSDSDAVLDAFPEAIMAEVADALAALRLSAAMAPVSRAHPTDCAPLVMDAVEDAATRLGYASMRLPSGAGHDAVYMAPTGPIGMIFVPCLNGRSHCPEEWLEPSQLLDGTRVLYETVLELDRRLSR
>NZ_CP044089.1|WP_003817016.1|3433076_3434459_-|MATE-family-efflux-transporter
MPQSTARAAWKRELAATLALSLPLVLTNLAQMAMTVTDVIFIGRLGSQALAASALGANLFTAIEFFGLGLVAATAPMVAHALGRRGNAVRDVRRTVRQGLWTAVIYSVPGCLLLWHGEAILLAIDQPPELAAQAGAYLRALMWAMPPFLGFLVLRSFVAALQRPRSAFLIALAAIVLNVFGNWVLVFGNLGAPALGLVGAGLASALATLGLFLGMVGVVCLDRRFRRYHLFGGVWQPDWQRLAEFWKLGLPIGAATAFEVTIFNAAAFLMGWLGEPELAAHAVAIQIASVTFMIPYGIAQAATVRVGHAYGARQPDQVARAGWCAFSLGIGSMAIAAALMLLAPGLLVSAFLDIGDPANAQVLRLATAYLAVAALFQIVDGAQVLGAGMLRGLHDTRVPMLYAAVGYWGVGLPSGAALAFWAGWRGVGVWSGLAIGLALVAVLMMQRWLRRDRVGLLRRA

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Crispr_ID: NZ_CP044089_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_6

3425024-3425085

Orphan

Consensus_repeat	Method
GGTGCCTGTCCCGGCGGGGACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_6

>merge|NZ_CP044089|6|3425024-3425085|CRISPRCasFinder
GGTGCCAGTCCCCGTGCGGGGACAGGCTAGAAGTTTGCGGGTGCCAGTCCCCGTGCGGGGAC

>NZ_CP044089|6|5|3425024-3425085|CRISPRCasFinder
GGTGCCAGTCCCCGTGCGGGGAC	AGGCTAGAAGTTTGCG
GGTGCCAGTCCCCGTGCGGGGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003812173.1\|3425098_3426451_-\|glutathione-disulfide-reductase	unknown	unknown	gnl\|CDD\|235701
NZ_CP044089.1\|WP_003817016.1\|3433076_3434459_-\|MATE-family-efflux-transporter	unknown	unknown	gnl\|CDD\|240536
NZ_CP044089.1\|WP_033448458.1\|3420912_3421818_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176160
NZ_CP044089.1\|WP_003817006.1\|3427364_3428060_+\|thiol:disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|172475
NZ_CP044089.1\|WP_003817003.1\|3426625_3426922_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_015041587.1\|3414731_3415556_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP044089.1\|WP_003817001.1\|3424128_3424773_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
NZ_CP044089.1\|WP_003817015.1\|3431784_3433047_-\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|237248
NZ_CP044089.1\|WP_003817010.1\|3429628_3430339_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224584
NZ_CP044089.1\|WP_003812166.1\|3431394_3431730_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239245
NZ_CP044089.1\|WP_003812180.1\|3419795_3420254_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP044089.1\|WP_033448484.1\|3421903_3422917_+\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|226105
NZ_CP044089.1\|WP_003816993.1\|3415507_3416482_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
NZ_CP044089.1\|WP_015041586.1\|3417568_3419782_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl\|CDD\|224446
NZ_CP044089.1\|WP_033448463.1\|3426946_3427324_+\|DUF2784-domain-containing-protein	unknown	unknown	gnl\|CDD\|378502
NZ_CP044089.1\|WP_015041582.1\|3428070_3429552_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP044089.1\|WP_003812179.1\|3420411_3420756_-\|exported-protein	unknown	unknown	gnl\|CDD\|288556
NZ_CP044089.1\|WP_050460974.1\|3416510_3417572_-\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|224886
NZ_CP044089.1\|WP_003817012.1\|3430465_3431392_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_CP044089.1\|WP_150349045.1\|3422924_3424043_-\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|237190

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_003812173.1\|3425098_3426451_-\|glutathione-disulfide-reductase	gnl\|CDD\|235701	PRK06116, PRK06116, glutathione reductase; Validated.	0
NZ_CP044089.1\|WP_003817016.1\|3433076_3434459_-\|MATE-family-efflux-transporter	gnl\|CDD\|240536	cd13131, MATE_NorM_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.	1.49385e-159
NZ_CP044089.1\|WP_033448458.1\|3420912_3421818_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176160	cd08471, PBP2_CrgA_like_2, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold. This CD represents the substrate binding domain of an uncharacterized LysR-type transcriptional regulator (LTTR) CrgA-like 2. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.9221e-98
NZ_CP044089.1\|WP_003817006.1\|3427364_3428060_+\|thiol:disulfide-oxidoreductase	gnl\|CDD\|172475	PRK13972, PRK13972, GSH-dependent disulfide bond oxidoreductase; Provisional.	9.78766e-82
NZ_CP044089.1\|WP_015041587.1\|3414731_3415556_+\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	3.93278e-06
NZ_CP044089.1\|WP_003817001.1\|3424128_3424773_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.64027e-44
NZ_CP044089.1\|WP_003817015.1\|3431784_3433047_-\|Zn-dependent-hydrolase	gnl\|CDD\|237248	PRK12890, PRK12890, allantoate amidohydrolase; Reviewed.	0
NZ_CP044089.1\|WP_003817010.1\|3429628_3430339_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	3.47026e-25
NZ_CP044089.1\|WP_003812166.1\|3431394_3431730_-\|thioredoxin-family-protein	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.67695e-05
NZ_CP044089.1\|WP_003812180.1\|3419795_3420254_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	8.69353e-72
NZ_CP044089.1\|WP_033448484.1\|3421903_3422917_+\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|226105	COG3576, COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only].	5.56942e-18
NZ_CP044089.1\|WP_003816993.1\|3415507_3416482_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	1.08848e-65
NZ_CP044089.1\|WP_015041586.1\|3417568_3419782_-\|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	1.17929e-123
NZ_CP044089.1\|WP_033448463.1\|3426946_3427324_+\|DUF2784-domain-containing-protein	gnl\|CDD\|378502	pfam10861, DUF2784, Protein of Unknown function (DUF2784). This is a family of uncharacterized protein. The function is not known however it is conserved in Bacteria.	5.8699e-36
NZ_CP044089.1\|WP_015041582.1\|3428070_3429552_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	7.14269e-131
NZ_CP044089.1\|WP_003812179.1\|3420411_3420756_-\|exported-protein	gnl\|CDD\|288556	pfam11720, Inhibitor_I78, Peptidase inhibitor I78 family. This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78.	2.38824e-32
NZ_CP044089.1\|WP_050460974.1\|3416510_3417572_-\|XdhC-family-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	6.06922e-58
NZ_CP044089.1\|WP_003817012.1\|3430465_3431392_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	9.6581e-14
NZ_CP044089.1\|WP_150349045.1\|3422924_3424043_-\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|237190	PRK12755, PRK12755, phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional.	0

>NZ_CP044089.1|WP_003817001.1|3424128_3424773_-|LysE-family-translocator
MRATMPEPTQLLAFALICLGMTLTPGPNMMYLVSRSLSQGYRAGLVSLAGVALGLVFYVLCAVLGITALLMAVPLAYEALCVAGAIYLMYMAWQALRPGGQSPFQVRALAPSPPRRLFAMGLFTALLNPKIAVLYLSLLPQFIDPQQGSVLTQSLALGFTQVGISICVNALFTVMAGAIAVFLARRPMWMVAQRWLMGSVLAGLAVRMALDARR
>NZ_CP044089.1|WP_150349045.1|3422924_3424043_-|3-deoxy-7-phosphoheptulonate-synthase
MTRIDDPLHDREAGQADATQDTTRIDDVRIGAVRPLISPALLQDELPVSAPLQALVEDSRARIADVLHGRDDRLVVVVGPCSIHDHEQAMEYARQLKEAADTLADDLLIVMRVYFEKPRTTVGWKGYINDPRLDGSFRINEGLRRARHLLLEIGALGLPIATEFLDLLSPQYIADLIAWGAIGARTTESPSHRQLASGLSCPLGFKNGTDGGIQVAADAIVAASAPHAFMGMTKMGTAAIFETRGNDDTHVILRGGKQGPNYDAAAIDACCAALARAGLREQVMVDCSHANSNKSHARQVDVARDLARQLAGGDRRIIGIMIESNLEEGRQDLKPGVPLKRGVSITDACLSWAQTEPVLAELAQAVRQRREG
>NZ_CP044089.1|WP_033448484.1|3421903_3422917_+|pyridoxamine-5'-phosphate-oxidase
MAVVRYDIPGALMSDSLVFHTDLPGLADGPWHGGELAMQERAGARERMAQLGPRVIRDHMPQQHRDFFAQLPFMLLATVDAQGDPWASVLEGPPGFAHSPDERTLRLDALPAGDDPARAGLAHGAGVGMLGIELSTRRRNRVNGHVAALDGQGFCVAVTQSFGNCPQYIQTRHARQTAPAPQPARWLAGLDAAARTLVGQADTLFVASYARQAGPHAVDVSHRGGPPGFVHLRGDTLTMPDFSGNRFFNTLGNLLANPRAGLVFVDFARGDLLQLCGRAEVLAEAGAPAAYPGAQRLWRVHVERAVRRPAALGLRAGFGEYAAQLAAVGQWAGEPPA
>NZ_CP044089.1|WP_033448458.1|3420912_3421818_+|LysR-family-transcriptional-regulator
MDKFQEVSLFLAVAEARSFAAAGRRLGLSASTVTRAVAALEARLGILLLVRTTRHVRLTDAGEQFAHDCRAVLDNLAQAEEAAAGGRVQPRGELSVTAPALFGELHVMPAIVDYLRQHRQVRLRALLVDRVVRLLDEGVDVAVRIGRLPDSSLTAIHVGDVRRIVCAAPDFLARAGVPSHPDMLPRYCTVSVVMEGQMDRWRFVCDGHARDLDVQAQLTVTSSQAAVRAAVQGWGLAQVVSYQAAGALREGALQVVLREFEPPPLPVHVVYPEGRKGAAKVRSFVEFCVERLRAELAGLPA
>NZ_CP044089.1|WP_003812179.1|3420411_3420756_-|exported-protein
MIWKLIPIALLAGLTACASGTRTDSSPPASSQTSSSAAPGSATTPSGPDCDAQPVQNLVGQKYSDSVGNDALRRSNSGSMRLLKPGQVMTMEYNARRLNIILEGNGSISALRCG
>NZ_CP044089.1|WP_003812180.1|3419795_3420254_-|(2Fe-2S)-binding-protein
MPTLNINGKDTVLDAPGEMPLLWALRDVADLTGTKYGCGMALCGACTVHADGQPIRACITPVQAVAGRRIVTIEGVAADRAGQAVQQAWRELDVAQCGYCQSGQIMSAAALLRANPAPTDRDIDDAMNGNICRCATYVRIRAAIHAAAAALA
>NZ_CP044089.1|WP_015041586.1|3417568_3419782_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MRIAIQNLSRRRFVQGAGGLLLGLSLPPLARRAMAAGPQAGDGFAANAFVRIGADGRVTVLAKHLEMGQGAYTGLATLLAEELDADWRQVRVEGAPADSARYGNQALGGLQGTGGSTAMFDSWEPMRRAGATARAMLVQAAAQRWQVPADTIEVAEGVLSHPASGRRAGFGELAEAAARSPVPQDVPLKDPARFRLIGKHRLPRVDSAAKSDGSALYTQDMKLPGMLVAVVAHAPRLGAAVARVDDAAARAVPGVRAVVRFGGAPLRHAGVAVLATNTWAARAGRDALRIEWDEGPAYRQGSADILARYREAVGRPGSMAARKGDIDAAFAGAAKVIEAEYTYPYLAHAAMEPLNCLVRLDDERCEIWNGEQFQTADQRAIAQYLGMPAERITLTQLYAGGSFGRRASSHADYLLEAVAIARTARAQGLNAPVKLVWMREEDMRAGYYRPLNLHRARLALGADGALQAVHVRMAGQSILLGTPLADWVRDGVDPVSVEGLSDLAYAVPNLQVELHTPTDVPVPVLWYRSVGHTHTAFSAETLIDEAAVAAGQDPVAYRLALLAAHPRHREVLQLAAARAGWREPLAAGAPGTRRGRGVAVHESFRSVVAQVVEVTIAADGALKVDRVVCAVHCGLAVNPDVVRAQMEGGIGFALSTALHGAITLKDGAVEQSNFHDYPVLRLAEMPAVEVHIAPSTQPPTGVGEPGVPPLAPALANAIAQATGQRLRTLPLGTTVKA
>NZ_CP044089.1|WP_050460974.1|3416510_3417572_-|XdhC-family-protein
MRSIAMQAADLYVLQTAQSWLDAGQAAVLLTVARTWGSSPRPPGAMMAIRADGAVAGSVSGGCIEDDLIDQIRQRGIAALCPGARPALATYGVDGEQARRFGLPCGGTLQLVLEPLGAHSRLEDLLARLRARQTVRRSVRLADGAVTLEPAAADAEPRLDGAGFASVLGPRHRLLVVGAGQLSRYLCEMAVALDFDVTVSDPREEYRAGWQVEGVALTTAMPDDMVIAARPDARTAVIALTHDPKLDDLALIDALQTPAFYVGALGSRANHARRVARLREHFGLTAAQLARLRGPAGIYIGSRTPPEIALSIMAEIVAGKNGAPLPPAASVAAGKARQPGSAGVIQAGLCATL
>NZ_CP044089.1|WP_003816993.1|3415507_3416482_-|AraC-family-transcriptional-regulator
MSALPDSPSASPPPRHDELASLIERHTPADGTTATALPGLNFYRSSSPTELNVSFYRPSLALLAQGAKRVQLGDDVYEYDTSHYLLTSFDLPVASRVTLATPGTPYLCFALDLDPHRIAGLISELGAPPAGQPLRRGLTLARLTEPLLDAVLRLARLLDTPADIPVLAPLIEREIHYRLLSGPMGGRLRHIARAEGTALQIARAIDWLRRHYAQPLRVEHLATTVNMSVSSLHHHFKAVTALSPLQYQKQLRLHEARRLMVAETLDAGAAAHRVGYESASQFSREYSRLYGAPPLRDAARLRGTAPADAQSPGLARASASATVS
>NZ_CP044089.1|WP_015041587.1|3414731_3415556_+|hypothetical-protein
MTGTMTIRIDEELRAYIDPLTPDEYAALEQSLLAEGCRDALVLWGDLLVDGHNRHAICSKHGIAFNTVQNTRLQSMDDVRLWMIDNHLGRRSVSDFQRGVLALRKKEILESRRQAGEGDAAPAGSDGPAPAPLTRQTLARQARLSSTTLGQIEKIRQQAAPELVRAVQSGEISINAAAAVATLPAPQQAAAAAGGRGELRAAARQVREARLPVRRAPEAEPAPAAEPRVVDDYPAEVARLDRLVAQLAEERDALKKKVVQLTVALAEARAKPGD
>NZ_CP044089.1|WP_003812173.1|3425098_3426451_-|glutathione-disulfide-reductase
MAFDFDLYVIGAGSGGVRAARFAAGYGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFHEDFEQAAGFGWNPGRPEFDWPTLIANKNREIERLNGIYRNLLVNSGVALHEGHARIVDPHTVEINGQRHSAQHILVATGGWPFVPDIPGKEHAITSNDAFFLPELPRRVLVVGGGYIAVEFASIFNGLGAQTVQVYRRELFLRGFDGSVREHLRDELVKKGLDLRFNTDVERIDKRADGVLAVTLSDGSVLETDCVFYATGRRAMLDDLGLENTGVRLAESGYIEVDDEYRTSEPSILAIGDVIGRVPLTPVALAEGMAVARRLFRPQEYRKVDYDLIPTAVFSLPNIGTVGLTTEQALERGFRVTRYESRFRPMKLTLTQSQEKTLMKLVVDADSQKVLGCHMVGPDAGEIVQGLAVALKAGATKQVFDDTIGIHPTAAEEFVTMRTAT
>NZ_CP044089.1|WP_003817003.1|3426625_3426922_+|hypothetical-protein
MQNEDSFFGSLGAILGAVIRAIVDGLRYVFGGLGRALGDFFGGLASALGMSPSVFNFALLVLGLLLLWTAVRAFMGRAIVAGIFWLVLAMLLLGGLIG
>NZ_CP044089.1|WP_033448463.1|3426946_3427324_+|DUF2784-domain-containing-protein
MLYRFLADLVLALHALFVAFVVLGGLLALRWPRLAWLHVPAALWGAGIMLAGAICPLTPLENHWRAQAGQQGYEDGFIAHYLLAAIYPEGLSRTAQTVLGGLALAGNALVYAALWRRRRRGGIGR
>NZ_CP044089.1|WP_003817006.1|3427364_3428060_+|thiol:disulfide-oxidoreductase
MIDLYFWATPNGLKIKLFLEEAGLPYTEHPINIGKGEQFQREFLAIAPNNRIPAIVDQAPAGGGAPISLFESGAILLYLAEKIGRFIPADVRGRAEVLQWLFWQMGGLGPMAGQNGHFNVYAPEKVPYAIERYTAETARLYDVMDRRLAEREFLAGEYSIADIACYPWVVPHEAHGQKMAHFPHLSRWFEAIAARPATARAYKEAGDSYRPKAPMSDEERTVLFGQPGAPR
>NZ_CP044089.1|WP_015041582.1|3428070_3429552_-|PLP-dependent-aminotransferase-family-protein
MIKSATNRLFDRAMDFAAILQQAPQAGARLPLQRQLLQRFKNAILDGRLAPGSRLPASRALAQQLGISRNTVLLAYEHLAAEGYVRADRQGTRVAGLARAGMPARASAASSAGPTARRLAALKASAPRTDTYLPLRPGTPALNHFPASAWRNALERALREAPAALLGYGEPAGEPRLRQAIAAYLAAARGVRCEARQIVITEGAQEGLALCVRLLGNAGDTAWVEDPGYRGAKTALRCGDMRVVPVRVDAAGLLAPPQAWRDAPPRLIYVTPSHQYPTGAVLPVTRRLALIEQARRAGAWIIEDDYDSEFRHQGEPIAAMQGLVPDAPVLYVGTYSKTMFPSLRLGFVVLPTGLADEAAEALAEMLRGGHRHEQWALASFIESGQFTRHLNRMRRLYRERQQALRAALARHLRVPHEVLGGHCGLHLTLRLPAALDDRAIAAQALRLGMAPQALSGFAIAPRPEDTGLVLGYGNTSAELFEPLIERLARLIQA
>NZ_CP044089.1|WP_003817010.1|3429628_3430339_+|GNAT-family-N-acetyltransferase
MPARVNEFGQPIGQAMPQWQARPRPPRDPAEGRYCRLEPLDAARHGEDLYAAFAVPDAASGWTYLSAGPFADRAGYDEYLRKAADSADPLHHAVIDLASGRAIGTLSLMRIDPANGVIEVGHVNFAPALRRSPASTEAQYLLMRRAFDELGYRRYEWKCDSLNAPSRAAALRLGFLFEGIFRQALVYKGRTRDTAWFSIIDSEWPALRAAFERWLAPENFDAAGRQRKRLDACRQP
>NZ_CP044089.1|WP_003817012.1|3430465_3431392_-|DMT-family-transporter
MAAAAPLRRPLDGFATYVMLALCICWGFQQIAIKLVAADVSPTLQIGLRSAFAAVVLIWVVLRHEGLGAFRDGTLGPGLAVGALFALEFLLVGVGLDYTTASHMAVFLYTAPIFTALGLHLLLPDERLKPLQWLGVAVAFGGIATAFLGKGHASVPGMLLGDLLGVLAGAAWGATTVAIRKSSLSEAAPAKTLFYQMLMAGLALPAFHFASGGAAPVWSGAALASLGFQSVVVALSSYLAWFWLLRRYLATRLAVLSFMTPLFGVTFGVLILDEPLDSGFVIGAVLVLAGITLVSGAELLREKLRRRT
>NZ_CP044089.1|WP_003812166.1|3431394_3431730_-|thioredoxin-family-protein
MDQIELTDGTADRYLLDAPGLSLLVFHSRTCATCGVARQRLPEFDLPVDRLCWIDAGENGGLVQRYEVFHLPALFVTRDGAYYGPVSAQLADWDLRQQISLALDSYPAELP
>NZ_CP044089.1|WP_003817015.1|3431784_3433047_-|Zn-dependent-hydrolase
MTTTFPPLNADRLWSRVETLSRMTLPDVPWTRRAFSPLFEQSRQWLRAEFEAAGLAVRLDAGGNLVGTRPGRDAARRPIATGSHCDTVMAGGRFDGIIGVLAGIEVAHTLHEQGVTLEHPFDVIDFLSEEPSDYGISCVGSRALSGQLTPDMLAARNADGETLAEGLRRIGGDPDALGAPLRGPGQTAAFVELHIEQGPVLESRGLPIGVVTNIVGIRRVLITVHGQPDHAGTTPMDIRRDALVGAARVIDAAHRRASAQSGKPHYVVATIGRIAMTPNAPNAVPGMVELMLEVRSDSDAVLDAFPEAIMAEVADALAALRLSAAMAPVSRAHPTDCAPLVMDAVEDAATRLGYASMRLPSGAGHDAVYMAPTGPIGMIFVPCLNGRSHCPEEWLEPSQLLDGTRVLYETVLELDRRLSR
>NZ_CP044089.1|WP_003817016.1|3433076_3434459_-|MATE-family-efflux-transporter
MPQSTARAAWKRELAATLALSLPLVLTNLAQMAMTVTDVIFIGRLGSQALAASALGANLFTAIEFFGLGLVAATAPMVAHALGRRGNAVRDVRRTVRQGLWTAVIYSVPGCLLLWHGEAILLAIDQPPELAAQAGAYLRALMWAMPPFLGFLVLRSFVAALQRPRSAFLIALAAIVLNVFGNWVLVFGNLGAPALGLVGAGLASALATLGLFLGMVGVVCLDRRFRRYHLFGGVWQPDWQRLAEFWKLGLPIGAATAFEVTIFNAAAFLMGWLGEPELAAHAVAIQIASVTFMIPYGIAQAATVRVGHAYGARQPDQVARAGWCAFSLGIGSMAIAAALMLLAPGLLVSAFLDIGDPANAQVLRLATAYLAVAALFQIVDGAQVLGAGMLRGLHDTRVPMLYAAVGYWGVGLPSGAALAFWAGWRGVGVWSGLAIGLALVAVLMMQRWLRRDRVGLLRRA

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Crispr_ID: NZ_CP044089_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_7

3652106-3652198

Orphan

Consensus_repeat	Method
CGGTGCCTGTCCCCGCGGGGACAGGCACCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_7

>merge|NZ_CP044089|7|3652106-3652198|CRISPRCasFinder
CGGTGCCTGTCCCCGCGGGGACAGGCACCCCGTCATGCGCCATGAACGCTTGACCACCAGGACGGTGCCTGTCCCCGCGGGGACAGGCACCCC

>NZ_CP044089|7|6|3652106-3652198|CRISPRCasFinder
CGGTGCCTGTCCCCGCGGGGACAGGCACCCC	GTCATGCGCCATGAACGCTTGACCACCAGGA
CGGTGCCTGTCCCCGCGGGGACAGGCACCCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003811740.1\|3645633_3646323_+\|VIT-family-protein	unknown	unknown	gnl\|CDD\|153123
NZ_CP044089.1\|WP_004567168.1\|3648557_3649184_+\|dTMP-kinase	unknown	unknown	gnl\|CDD\|234814
NZ_CP044089.1\|WP_003811721.1\|3653958_3654627_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
NZ_CP044089.1\|WP_015041526.1\|3662413_3663352_-\|citrate-lyase-subunit-beta	unknown	unknown	gnl\|CDD\|225184
NZ_CP044089.1\|WP_003811716.1\|3656539_3657829_+\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NZ_CP044089.1\|WP_015041528.1\|3651103_3651940_+\|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl\|CDD\|293786
NZ_CP044089.1\|WP_004567173.1\|3642977_3644150_+\|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl\|CDD\|379770
NZ_CP044089.1\|WP_033448020.1\|3650282_3651053_+\|TatD-family-hydrolase	unknown	unknown	gnl\|CDD\|238635
NZ_CP044089.1\|WP_033450579.1\|3646331_3647348_-\|folate-binding-protein-YgfZ	unknown	unknown	gnl\|CDD\|223431
NZ_CP044089.1\|WP_003817274.1\|3659450_3660698_-\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|237250
NZ_CP044089.1\|WP_003817272.1\|3655393_3656347_+\|formimidoylglutamase	unknown	unknown	gnl\|CDD\|172310
NZ_CP044089.1\|WP_003811741.1\|3645136_3645574_+\|PaaI-family-thioesterase	unknown	unknown	gnl\|CDD\|239527
NZ_CP044089.1\|WP_003817260.1\|3647514_3648561_+\|endolytic-transglycosylase-MltG	unknown	unknown	gnl\|CDD\|224475
NZ_CP044089.1\|WP_015041527.1\|3660707_3662417_-\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|181285
NZ_CP044089.1\|WP_033461229.1\|3649180_3650233_+\|DNA-polymerase-III-subunit-delta'	unknown	unknown	gnl\|CDD\|235898
NZ_CP044089.1\|WP_003811719.1\|3654623_3655397_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_CP044089.1\|WP_003817271.1\|3653218_3653962_+\|glutamine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270216
NZ_CP044089.1\|WP_004567164.1\|3652405_3653143_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP044089.1\|WP_003811743.1\|3644197_3645091_+\|3-hydroxyisobutyrate-dehydrogenase	unknown	unknown	gnl\|CDD\|130753
NZ_CP044089.1\|WP_033453904.1\|3657904_3659401_-\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143430

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_003811740.1\|3645633_3646323_+\|VIT-family-protein	gnl\|CDD\|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	4.29258e-88
NZ_CP044089.1\|WP_004567168.1\|3648557_3649184_+\|dTMP-kinase	gnl\|CDD\|234814	PRK00698, tmk, thymidylate kinase; Validated.	2.33411e-97
NZ_CP044089.1\|WP_003811721.1\|3653958_3654627_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.52729e-82
NZ_CP044089.1\|WP_015041526.1\|3662413_3663352_-\|citrate-lyase-subunit-beta	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	1.48341e-40
NZ_CP044089.1\|WP_003811716.1\|3656539_3657829_+\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	0
NZ_CP044089.1\|WP_015041528.1\|3651103_3651940_+\|ankyrin-repeat-domain-containing-protein	gnl\|CDD\|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.75947e-24
NZ_CP044089.1\|WP_004567173.1\|3642977_3644150_+\|enoyl-CoA-hydratase/isomerase-family-protein	gnl\|CDD\|379770	pfam16113, ECH_2, Enoyl-CoA hydratase/isomerase. This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.	2.53336e-158
NZ_CP044089.1\|WP_033448020.1\|3650282_3651053_+\|TatD-family-hydrolase	gnl\|CDD\|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	6.84867e-112
NZ_CP044089.1\|WP_033450579.1\|3646331_3647348_-\|folate-binding-protein-YgfZ	gnl\|CDD\|223431	COG0354, COG0354, Predicted aminomethyltransferase related to GcvT [General function prediction only].	9.10467e-52
NZ_CP044089.1\|WP_003817274.1\|3659450_3660698_-\|Zn-dependent-hydrolase	gnl\|CDD\|237250	PRK12893, PRK12893, Zn-dependent hydrolase.	0
NZ_CP044089.1\|WP_003817272.1\|3655393_3656347_+\|formimidoylglutamase	gnl\|CDD\|172310	PRK13772, PRK13772, formimidoylglutamase; Provisional.	7.20672e-177
NZ_CP044089.1\|WP_003811741.1\|3645136_3645574_+\|PaaI-family-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.03018e-28
NZ_CP044089.1\|WP_003817260.1\|3647514_3648561_+\|endolytic-transglycosylase-MltG	gnl\|CDD\|224475	COG1559, COG1559, Aminodeoxychorismate lyase [Coenzyme transport and metabolism].	3.85258e-127
NZ_CP044089.1\|WP_015041527.1\|3660707_3662417_-\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|181285	PRK08199, PRK08199, thiamine pyrophosphate protein; Validated.	0
NZ_CP044089.1\|WP_033461229.1\|3649180_3650233_+\|DNA-polymerase-III-subunit-delta'	gnl\|CDD\|235898	PRK06964, PRK06964, DNA polymerase III subunit delta'; Validated.	2.94344e-98
NZ_CP044089.1\|WP_003811719.1\|3654623_3655397_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	8.97945e-142
NZ_CP044089.1\|WP_003817271.1\|3653218_3653962_+\|glutamine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270216	cd00994, PBP2_GlnH, Glutamine binding domain of ABC-type transporter; the type 2 periplasmic binding protein fold. This periplasmic substrate-binding component serves as an initial receptor in the ABC transport of glutamine in bacteria and eukaryota. GlnH belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.32798e-115
NZ_CP044089.1\|WP_004567164.1\|3652405_3653143_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	5.57478e-48
NZ_CP044089.1\|WP_003811743.1\|3644197_3645091_+\|3-hydroxyisobutyrate-dehydrogenase	gnl\|CDD\|130753	TIGR01692, 3-hydroxyisobutyrate_dehydrogenase_mitochondrial, 3-hydroxyisobutyrate dehydrogenase. 3-hydroxyisobutyrate dehydrogenase is an enzyme that catalyzes the NAD+-dependent oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde of the valine catabolism pathway. In Pseudomonas aeruginosa, 3-hydroxyisobutyrate dehydrogenase (mmsB) is co-induced with methylmalonate-semialdehyde dehydrogenase (mmsA) when grown on medium containing valine as the sole carbon source. The positive transcriptional regulator of this operon (mmsR) is located upstream of these genes and has been identified as a member of the XylS/AraC family of transcriptional regulators. 3-hydroxyisobutyrate dehydrogenase shares high sequence homology to the characterized 3-hydroxyisobutyrate dehydrogenase from rat liver with conservation of proposed NAD+ binding residues at the N-terminus (G-8,10,13,24 and D-31). This enzyme belongs to the 3-hydroxyacid dehydrogenase family, sharing a common evolutionary origin and enzymatic mechanism with 6-phosphogluconate. HIBADH exhibits sequence similarity to the NAD binding domain of 6-phosphogluconate dehydrogenase above trusted (pfam03446). [Energy metabolism, Amino acids and amines].	1.50212e-129
NZ_CP044089.1\|WP_033453904.1\|3657904_3659401_-\|aldehyde-dehydrogenase	gnl\|CDD\|143430	cd07112, ALDH_GABALDH-PuuC, Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like. NADP+-dependent, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase (GABALDH) PuuC of Escherichia coli which catalyzes the conversion of putrescine to 4-aminobutanoate and other similar sequences are present in this CD.	0

>NZ_CP044089.1|WP_015041528.1|3651103_3651940_+|ankyrin-repeat-domain-containing-protein
MKPLRTRFLRWRGAAAGGLLAGALLASPAWAAKQADWWVYVHNDKARDISALLAAGADPNVRYDNGQPAIMRAVVDNAWEVFDVLAANRRTDLNAENPAGETPLMYLAVAGQTERAQALIARGAQVNRLGWTPLHYAASKGRLETARMLLGKQALVNAPSPDGTTPLMMAAYSGDRRMVQLLLDAGGDITTRNLKGMSAADWAAFGKSEALARELKPMIARAEAERQARHGAVATPKLAPAAETPPAAQPAAAPAAASQPGEGRSLSGVSGVRLNSYD
>NZ_CP044089.1|WP_033448020.1|3650282_3651053_+|TatD-family-hydrolase
MYVDSHCHLNFPELAQDLPAVLDRMAANQVTHALVVSVNMPDWPGLMQLVEPHGNLWASVGVHPDYEDTPDPEPAELERLAAHPKVVAIGETGLDYYRLSEPLDWQRERFRRHIRAARSTGLPLIVHTRASAQDTVRLLREEGADEVGGVMHCFTESWEIAQQAMALNFHISLSGIVTFKNAQLVHEVAANMPLDRLLIETDSPYLAPVPYRGKLNDPSKVIHVAEKIAELKGIPVAEVAHASTENFFKLFNKIKR
>NZ_CP044089.1|WP_033461229.1|3649180_3650233_+|DNA-polymerase-III-subunit-delta'
MSLGRFLPWQTEIARSWLSERDRFAHAWLIHGNGGIGKLDFAAAAAASLLCESPRQGLACGECAACAWVTSGNHPDLRRIRPEAVALEEGADQAEGAEEAEAGSGGGAAKRAPSKDIRIDQIRALEPWFNTATHRGGWRVALLYPAHALNVISANALLKVLEEPPAHTVFLLVADAPDRLLPTLVSRCRRLPLPTPSAGQALQWLGEQGVEPAADWLAAAGGAPLAAQRLAARGDAPCPAWLAQLVQPLAAGKAPDVGTLTENLEKVAAAEWIDALQRLFTDLTLAAHGAASRYYPSLAEPVRQAAARAQPAQLAETARWLSRQRGLATHPLNAKLFVHAALQRVVLSCQ
>NZ_CP044089.1|WP_004567168.1|3648557_3649184_+|dTMP-kinase
MTPRGRFITLEGVDGAGKSTHTAWMVQALRDLGLTVLATREPGGTPVGEKLRELLLSEPMTLETETLLMFAARCEHVREVIAPALARGEWVVCDRFTDASYAYQGGGRQLGAARVAALEQWVHPDLQPDRTWLFDVPLDVARARLARSRQLDRFEREEDAFFERTRAAYHERARSSDGRIRIIDSSRPLEVVRAQLDSEVRELVAQAA
>NZ_CP044089.1|WP_003817260.1|3647514_3648561_+|endolytic-transglycosylase-MltG
MRTLMRKRIRFYFLLLVLVALLGAALAVGGAWTWMHRPVALKSDRIDFVVDPGSTPRAIARTLNQAGVAVWEPGFVWMARLSELDKQIKAGGYQAINGDSPWQLLQRLARGDMSQRQITFLEGWTFRQMRQALREHPDVKQTLGETSDEALMERLGSTVTHPEGMFFPDTYVFTPGSTDFDILRRAYQEGQRILESTWAKRQEGLPVGTPYEALILASIVEKETGHGPERARVAGVFANRLRIGMLLQTDPTVIYGMGEAYQGRIRKRDLQTDTPWNTYTRPGLPPTPIAAPGRAALLAAVQPERHKYLFFVSRGNGTSEFSVNLNDHNRNVSRYILGQGQPQQGSQQ
>NZ_CP044089.1|WP_033450579.1|3646331_3647348_-|folate-binding-protein-YgfZ
MHAFYDSIPARADGSAQCAPLASLRVIGAAGADALAFLHGQLTQDVTGQPADHARLAGYCTAKGRLLATLVMWRAAAADESAPVWQALVRADVAEAVLKRLSMFVLRAKARLAPVPAWAAGVQCAPAALAALQDAAGGALPAAPWQRAELPTGTWIGAPSADAQPRWWWIATEAQLEQAGALAAHLGRASESAWQAADLAAGLPWIGAATQDVFIPQTVNLDLIGGVSFTKGCYPGQEVVARSHYRGTVKRRMAHGVIAAAPADLPEPLAGQDIYDSARPDEPCGRVVDAARSDGQLALLFETTLASLPDGDLRLLSAQGPRIALAPLPYELAGNAAG
>NZ_CP044089.1|WP_003811740.1|3645633_3646323_+|VIT-family-protein
MPARSHHRIFRSGWLRAAVLGANDGIVSTASLIAGVAAAQASHAAILTSGLAGLVAGALSMAAGEYVSVKSQADIEAADLRLEQSSLKRNSREELEELTGIYVERGLSPDLAGQVARQLTRHNALDAHARDELGISVHNRAQPVQAALASAASFAVGAALPLAIAMAAPLAQLMPVVIAGSVAGLGILGAVAARAGGAPVGPAAVRVVLLGAAAMALTAGVGALFGVAV
>NZ_CP044089.1|WP_003811741.1|3645136_3645574_+|PaaI-family-thioesterase
MPDTEAFEAARQRVHDNFARQSVMALIGARLGAVEPGEVEIALPYRADLCQQNGFLHAGISTTIADSAGGYAAYTLFGPGEDVLTSEFKMNFLAPADGEHFVASGKVLKPGRRLSICQVELRACRGERSTLCLVGLMTAVRVTPR
>NZ_CP044089.1|WP_003811743.1|3644197_3645091_+|3-hydroxyisobutyrate-dehydrogenase
MSSIAFIGLGNMGAPMALNLVKAGHDLTVFDLVPAAVKTLTDAGARAAGSAAEAVQGAELVISMLPASKHVEGLYLGQDLLASIGASALVIECSTIAPDSARKVAAAAQARGIAMIDAPVSGGTGGAAAGTLTFIVGGEAPALERARPVLASMGKNIFHAGGAGAGQVAKICNNMLLGILMAGTSEALALGVANGLDPKVLSDIISKSSGRNWATELYNPWPGVMEHAPASKGYAGGFGVDLMLKDLGLAAEAALGTRSSIPLGELARNLYSLHSQGGSGGLDFSSIVNLYSPGERN
>NZ_CP044089.1|WP_004567173.1|3642977_3644150_+|enoyl-CoA-hydratase/isomerase-family-protein
MNAPVLFEERIADNGVRLGVATLNAPQTLNGLSLEMVELLDARLRAWADDAAVAMVILQGAGEKAFCAGGDLHGLYRSMRENTGGDPWANTHARRFFEHEYRLDYLIHTYPKPVLCWGHGIVMGGGVGLMMGASHRVVSETTRMAMPEITIGLFPDVGGSWLLNRMPGRTGLFLALTGAHVNASDAFFAGLADFRLDSAQWPDFCASLLSLPWAGQPGGPGTGNAAPRSINDGLLRQALLAHEPATQLEPGPLRQHSFLVNSLCSGKRLDDIYAEIAELKDHADPWLARAAATMLAGSPGSARLAYALQQHTRLRSLADVFRIEYVAALACAAHGDFAEGIRALLVDKDRQPRWNPATLSEASDDWVRKFFDEPWPAGQPHPLADLGHGA
>NZ_CP044089.1|WP_004567164.1|3652405_3653143_+|IclR-family-transcriptional-regulator
MQEQAIAGGAERVLYVLATLAREEAPLTVAALAERTGLAQSTLYRQVALLKRWGFVLEQAGAYTPGPLCVQLARGFDQSSYLIQEALPDMTRLAADSGETVGLLVAMSDQAVCLEMVESRHPLRCSFVKGRGLPLARGASAKSLMAFMAPARLQGRLHELAGQGVDAAALARDLEAIRAAGYAVSDSEVDAGVWGCSAPVFERPHQAAGSITLMAPSTRVADRTTTLINLTLAAAKRISSRLQHA
>NZ_CP044089.1|WP_003817271.1|3653218_3653962_+|glutamine-ABC-transporter-substrate-binding-protein
MTTRRQLLTAALTLSLAWGAGAAHAQETIRAVTDATFPPMEFVKDGKRTGFDIELVEALAQAMGKKIEWIDIDFKGLIPALQAGRADIAVSAIYITAERQKVVDFTDPYYAGGLVVLTKKDGPVKSLKDLEGRKVSVQVGTKSVNYLKEHFPKVQRVEVEKNQEMFNLVQIGRADAAVTGKPAAKLFAQSTQDLTVLGEQITTEEYGIAVPKSKSGLTRELNEALKKLKADGTYERIVNKWFEAQAK
>NZ_CP044089.1|WP_003811721.1|3653958_3654627_+|amino-acid-ABC-transporter-permease
MMLDFAPVFADFDALLRGAVVTVEVTACALLLGCVIGLLVGVGRLNPQRRFIYNLCSVYLLFFRGTPLLVQLFIWFFGLPQFGITLPAFACGVLGLGIYSGAYVSEIVRGAIQSVDRGQMEAARSLGMSSAQAMRIIILPQAVVRMIPPLGNEFIALIKNSALVSLLTIHDLMHEGQKIISVSYRSLETYLVVALIYLVLTTATTTILRRIEHRLRAGGMVQ
>NZ_CP044089.1|WP_003811719.1|3654623_3655397_+|amino-acid-ABC-transporter-ATP-binding-protein
MSTQEMIRIRGLRKAYGEHEVLRGIDFNVEASQVVVVIGPSGSGKSTLLRCCNGLEVAQGGTIDICGHNLLKDGRLLPEAELNRLRMQVGMVFQGFNLFPHLSVLDNVTVGPRTLRGMSRAQAEELGGDLLAKVGLREKMAAMPGSLSGGQKQRVAIARALAMQPRVMLFDEPTSALDPELVGEVLQVMKLLAREGMTMMVVTHEMGFAREVADVVAVMDGGSIVESGPPELIFSQPREARTRAFLQAVLSASQGAA
>NZ_CP044089.1|WP_003817272.1|3655393_3656347_+|formimidoylglutamase
MSVANDSASIWTARDDSGERGDTRRLAHIVALGQDAGAGDPAVLGFACDAGVARNQGRRGAALAPRAIRRMMAGLPAHNLRRLVDAGDVVCEDDQLEAAQDALAGRVAALLQAGAHPVVLGGGHEIAWGSFQGLRRWLDARGDREPVLVLNLDAHFDLRTGRPGSSGTPFDQIAEYCAARGHALQYACLGVSPLGNTPALFARAAETGAVWVEDRDMQEAHLGARLAQLDTLLAAAGHVYLTIDLDVLPAATAPGVSAPAPYGVPLAVVEEVAMHVRASGKLRLADLAECNPAYDIDHRTARVAARLAWRLLGGAAR
>NZ_CP044089.1|WP_003811716.1|3656539_3657829_+|Glu/Leu/Phe/Val-dehydrogenase
MSQAPAHSLPSYLDAEHLGPWGIYLQQVDRVTPYLGPLARWVETLKRPKRALIVDVPIEMDNGSIAHFEGYRVQHNTSRGPGKGGVRFHQDVTLSEVMALAAWMSIKNAAVNLPYGGAKGGVRVDPRTLSHSELERMTRRYTSEIGVIIGPSKDIPAPDVNTNAQTMAWMMDTYSMNEGATATGVVTGKPIALGGSLGRVEATGRGVFVVGCEAARDLNLDVSKARIVVQGFGNVGGTAARLFHEAGAKVIAVQDHTGTIHNDGGLDVHKLLAHVGNQGGVAGFTGAQQLADDDFWGLETDFLIPAALEGQINENNAARVRAKVVVEGANGPTTPEADDILRENGVYVVPDVLANAGGVTVSYFEWVQDFSSFFWSEEEINQRLERLMREAYSAVSQVAKEHKVTLRTAAFIVACTRILQARQVRGLYP
>NZ_CP044089.1|WP_033453904.1|3657904_3659401_-|aldehyde-dehydrogenase
MTLHDSAYWRAQAAALAPEGRAYIDGAYCDAADGATFAAHSPIDGRKLADVAACGAADVDRAVAAARRAFEAGVWSGLAPRERKNRLLRLAALITEHQEELALLETLDMGKPIRDALAFDLPETARCYAWYGEAIDKRYDEIAPTGADALATITREPLGVVAAVVPWNYPLMMAAWKVAPALAVGNSVILKPAEQASLSALRLAALAEQAGIPPGVFSVVPGLGAQAGQALGLHPDVDCIAFTGSTATGKRFMTYSGQSNLKRVWLECGGKSPHIVFADCPDLDRAAQVAALAIFSNQGEVCIAGSRLYVQHGIYDAFMEKVAAFAATLRPGNPLDPDSALGAMVDERQTQAVMARIAAGAQEGARLRLGGRQVLADSGGYYIEPTIFDCPGQDNSLVREEIFGPVLAAQGFADEDEAVALANDSIYGLGAGLWTADLGRAHRLSRRLRAGLVWVNCYADGDITVPFGGVKQSGFGRDKSLHAMDKYSDLKTTWISLR
>NZ_CP044089.1|WP_003817274.1|3659450_3660698_-|Zn-dependent-hydrolase
MSNNSPISIDGQRLWQSLMDLARIGATPKGGNCRLALTALDGQGRDLVTGWMRDAGLTVRVDQVGNIFARRAGRDPSRAPVMTGSHIDTQPTGGKFDGCYGVLAGLEVMRTLDDHGVQTDAPLEVAIWTNEEGSRFLPVMMGSGVFAGKFPLETALTARDADGKSVADELRAIGYAGADPVGGRAVDAYFEAHIEQGPILEHEERIVGVVTGSLGVRWYDVVVQGMEMHAGPTPMPIRKDALYAASHLLQAVVEIANAHQPHGRGTVGEIHAYPGSRNVIPGQVRFTVDLRHEDEATLATMDALWRQACADTAARHAVSVQCEQVQYFAPTPFHPDLVGKVRDGAQRRGLPAMDIVTGAGHDAVYMAAVAPTAMIFVPCKDGISHNEIEDAQPAHLEAGCNVLLDAMVARANAPR
>NZ_CP044089.1|WP_015041527.1|3660707_3662417_-|thiamine-pyrophosphate-binding-protein
MTTPALPERNGGQILMQQLRVHGARRVFMIPGESYLPCIDALNEHRGAIDAIVCRQESGAAYMAEAYGKLTGEPGICFVTRGPGATNASIGVHTAYQDSTPMILFIGQVGNDFMEREAFQEIDYRRMFGQMAKWVAQIDRTERIPEFIARAFAVATSGRPGPVVLALPEDTLWGRARVADMPRYQRARSLPGAADLARMVELLDQAERPFMLLGGTGWSAEAIGQAAAFAERFELPVGTAWRRLECFDQRHPNAAGHVGWAMAPELRQRIAGADLVLAVGTRMGEATTEGYTVIESPLPRQRLVHVYPDPNELGRVFAPTLGIVADPAGFAAALDALRPGHRASRAQAVRAAHDEYLATLAPLPSPGPLNLDSAAAYVNQHIPADACITVGAGNYALYPHRYRQFSGPGTSLAPTVGSMGYGLPAAISAKLENPARTVVCYAGDGCFQMNMQELGVALQYRVGVVVLVFNNGIWGTIRAHQERDFPGRAIALDFQNPDFTQFVRAYGGYGEAVERTEDFGPAFERARAFAEREQLPALLEIRYEADGIAPGQTLTEIRQAAQAQAAGVQ
>NZ_CP044089.1|WP_015041526.1|3662413_3663352_-|citrate-lyase-subunit-beta
MTPISDPGGQRRPASLRRSWMFVPGLLEQAQAAGLASGADALVADLEEFTAPADRPAARRRIVALLAQCRAAGVIGAVRINKLEEDGLDDLRGIMAGAPDAIFLPHAESAAQIAALDRAISACEAEAGLAPGSTEIVPTLESALGVTRACEILTASPRVSACLLAAEDLTASLGAERGPDGIELHALRARFLVDCVAAGCLPIDCPFNYRDPAAQQADLLWARRIGLKSKCAVFAEQVPAIHAAFTPDADRVAAARDLAARFEAQRDGRDAGGARVDPPDYNTARRLLARHAEFEQWAARAARPRESQGEQS

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Crispr_ID: NZ_CP044089_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_8

3896822-3896894

Orphan

Consensus_repeat	Method
GTGTGCCTGTCCCGGCGGGGACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_8

>merge|NZ_CP044089|8|3896822-3896894|CRISPRCasFinder
GTGTGCCTGTCCCGGCGGGGACAGATACCGTCTTCGATGGCGCACGGCAGTGTGCCTGTCCCAGCGGGGACAG

>NZ_CP044089|8|7|3896822-3896894|CRISPRCasFinder
GTGTGCCTGTCCCGGCGGGGACAG	ATACCGTCTTCGATGGCGCACGGCA
GTGTGCCTGTCCCAGCGGGGACAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003817612.1\|3895335_3895950_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|182533
NZ_CP044089.1\|WP_033466889.1\|3894038_3895211_-\|PQQ-dependent-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|369642
NZ_CP044089.1\|WP_003817614.1\|3898430_3899669_-\|high-affinity-branched-chain-amino-acid-ABC-transporter-permease-LivM	unknown	unknown	gnl\|CDD\|236896
NZ_CP044089.1\|WP_033460795.1\|3891487_3891985_-\|DUF2384-domain-containing-protein	unknown	unknown	gnl\|CDD\|131346
NZ_CP044089.1\|WP_003811272.1\|3899668_3900595_-\|high-affinity-branched-chain-amino-acid-ABC-transporter-permease-LivH	unknown	unknown	gnl\|CDD\|182689
NZ_CP044089.1\|WP_003811271.1\|3900697_3901813_-\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|237959
NZ_CP044089.1\|WP_003817609.1\|3892506_3893391_+\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|273359
NZ_CP044089.1\|WP_003817617.1\|3905194_3906076_+\|sn-glycerol-3-phosphate-ABC-transporter-permease-UgpA	unknown	unknown	gnl\|CDD\|182550
NZ_CP044089.1\|WP_033450462.1\|3888799_3890008_+\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|376451
NZ_CP044089.1\|WP_150349089.1\|3896066_3896810_+\|amino-acid-racemase	unknown	unknown	gnl\|CDD\|376478
NZ_CP044089.1\|WP_003811277.1\|3897666_3898434_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|183080
NZ_CP044089.1\|WP_003817606.1\|3890020_3890836_-\|exported-protein	unknown	unknown	gnl\|CDD\|224381
NZ_CP044089.1\|WP_004566885.1\|3902083_3902665_-\|queuosine-precursor-transporter	unknown	unknown	gnl\|CDD\|224652
NZ_CP044089.1\|WP_003811293.1\|3892132_3892510_+\|DUF423-domain-containing-protein	unknown	unknown	gnl\|CDD\|225238
NZ_CP044089.1\|WP_003817613.1\|3896964_3897666_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
NZ_CP044089.1\|WP_003811288.1\|3893403_3894042_-\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|198297
NZ_CP044089.1\|WP_003811264.1\|3903705_3905019_+\|sn-glycerol-3-phosphate-ABC-transporter-substrate-binding-protein-UgpB	unknown	unknown	gnl\|CDD\|182876
NZ_CP044089.1\|WP_003811259.1\|3906095_3906947_+\|sn-glycerol-3-phosphate-ABC-transporter-permease-UgpE	unknown	unknown	gnl\|CDD\|182875
NZ_CP044089.1\|WP_003817607.1\|3890969_3891491_-\|RES-family-NAD+-phosphorylase	unknown	unknown	gnl\|CDD\|378053
NZ_CP044089.1\|WP_003817616.1\|3902661_3903495_-\|pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|237008

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_003817612.1\|3895335_3895950_+\|glutathione-S-transferase	gnl\|CDD\|182533	PRK10542, PRK10542, glutathionine S-transferase; Provisional.	5.23085e-51
NZ_CP044089.1\|WP_033466889.1\|3894038_3895211_-\|PQQ-dependent-sugar-dehydrogenase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	0
NZ_CP044089.1\|WP_003817614.1\|3898430_3899669_-\|high-affinity-branched-chain-amino-acid-ABC-transporter-permease-LivM	gnl\|CDD\|236896	PRK11301, livM, leucine/isoleucine/valine transporter permease subunit; Provisional.	0
NZ_CP044089.1\|WP_033460795.1\|3891487_3891985_-\|DUF2384-domain-containing-protein	gnl\|CDD\|131346	TIGR02293, conserved_protein_of_unknown_function, putative toxin-antitoxin system antitoxin component, TIGR02293 family. Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. This family was proposed by Makarova, et al. (2009) to be the antitoxin component of a new class of type 2 toxin-antitoxin system, or addiction module. [Cellular processes, Other].	6.6423e-54
NZ_CP044089.1\|WP_003811272.1\|3899668_3900595_-\|high-affinity-branched-chain-amino-acid-ABC-transporter-permease-LivH	gnl\|CDD\|182689	PRK10740, PRK10740, high-affinity branched-chain amino acid ABC transporter permease LivH.	8.45855e-114
NZ_CP044089.1\|WP_003811271.1\|3900697_3901813_-\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|237959	PRK15404, PRK15404, high-affinity branched-chain amino acid ABC transporter substrate-binding protein.	0
NZ_CP044089.1\|WP_003817609.1\|3892506_3893391_+\|DMT-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	3.27604e-10
NZ_CP044089.1\|WP_003817617.1\|3905194_3906076_+\|sn-glycerol-3-phosphate-ABC-transporter-permease-UgpA	gnl\|CDD\|182550	PRK10561, PRK10561, sn-glycerol-3-phosphate ABC transporter permease UgpA.	8.59638e-120
NZ_CP044089.1\|WP_033450462.1\|3888799_3890008_+\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	2.84643e-151
NZ_CP044089.1\|WP_150349089.1\|3896066_3896810_+\|amino-acid-racemase	gnl\|CDD\|376478	pfam01177, Asp_Glu_race, Asp/Glu/Hydantoin racemase. This family contains aspartate racemase, maleate isomerases EC:5.2.1.1, glutamate racemase, hydantoin racemase and arylmalonate decarboxylase EC:4.1.1.76.	3.97153e-55
NZ_CP044089.1\|WP_003811277.1\|3897666_3898434_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|183080	PRK11300, livG, leucine/isoleucine/valine transporter ATP-binding subunit; Provisional.	0
NZ_CP044089.1\|WP_003817606.1\|3890020_3890836_-\|exported-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.91033e-79
NZ_CP044089.1\|WP_004566885.1\|3902083_3902665_-\|queuosine-precursor-transporter	gnl\|CDD\|224652	COG1738, yhhQ, Uncharacterized member of the PurR regulon [General function prediction only].	3.70388e-35
NZ_CP044089.1\|WP_003811293.1\|3892132_3892510_+\|DUF423-domain-containing-protein	gnl\|CDD\|225238	COG2363, COG2363, Uncharacterized small membrane protein [Function unknown].	2.41803e-27
NZ_CP044089.1\|WP_003817613.1\|3896964_3897666_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	1.84899e-130
NZ_CP044089.1\|WP_003811288.1\|3893403_3894042_-\|glutathione-S-transferase	gnl\|CDD\|198297	cd03188, GST_C_Beta, C-terminal, alpha helical domain of Class Beta Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain. Unlike mammalian GSTs which detoxify a broad range of compounds, the bacterial class Beta GSTs exhibit GSH conjugating activity with a narrow range of substrates. In addition to GSH conjugation, they are involved in the protection against oxidative stress and are able to bind antibiotics and reduce the antimicrobial activity of beta-lactam drugs, contributing to antibiotic resistance. The structure of the Proteus mirabilis enzyme reveals that the cysteine in the active site forms a covalent bond with GSH. One member of this subfamily is a GST from Burkholderia xenovorans LB400 that is encoded by the bphK gene and is part of the biphenyl catabolic pathway.	2.90026e-25
NZ_CP044089.1\|WP_003811264.1\|3903705_3905019_+\|sn-glycerol-3-phosphate-ABC-transporter-substrate-binding-protein-UgpB	gnl\|CDD\|182876	PRK10974, PRK10974, sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB.	0
NZ_CP044089.1\|WP_003811259.1\|3906095_3906947_+\|sn-glycerol-3-phosphate-ABC-transporter-permease-UgpE	gnl\|CDD\|182875	PRK10973, PRK10973, sn-glycerol-3-phosphate ABC transporter permease UgpE.	4.6658e-141
NZ_CP044089.1\|WP_003817607.1\|3890969_3891491_-\|RES-family-NAD+-phosphorylase	gnl\|CDD\|378053	pfam08808, RES, RES domain. This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	5.95167e-20
NZ_CP044089.1\|WP_003817616.1\|3902661_3903495_-\|pyrroline-5-carboxylate-reductase	gnl\|CDD\|237008	PRK11880, PRK11880, pyrroline-5-carboxylate reductase; Reviewed.	9.19989e-106

>NZ_CP044089.1|WP_150349089.1|3896066_3896810_+|amino-acid-racemase
MTAPTQSCYLGVLGGMGPMAGAAFALRLAALTPAQSDQQHIPTLLLNDPRIPDRSNARTQGGEDPLPAMIAGMRFLREAGARLIAIPCNTAHLWYEPLAAVAGCTVLHIIEAVAQDLRRQGLHGGRIGLMGTSATLALGLYQQTLQRQGYSCIIPEPDEVERYCMGSIRAVKANRLDLAYEPAAECIARLKARGADAVVLGCTELPLAVPHALRPGLEIRLTDSIDALALAAIEHYEADQQAQKLVA
>NZ_CP044089.1|WP_003817612.1|3895335_3895950_+|glutathione-S-transferase
MKLYYMAGACSLAAHIVLEWIGKPYETHALSREALKEPAFLKINPLGAVPALTEGDWVLTQNAAILEYLAEQAPQLNLLGDGTARSRAEVRRWLGFINSDVHKTFSAVFGPQRFVADAAAQEEVRASAAAMLRGLFGQLDTHLQGRSFLAGARPSIADAYLYVVLRWAHGKQIDLSGQDNLAAFFERMQADPAVQAALKAEGLS
>NZ_CP044089.1|WP_033466889.1|3894038_3895211_-|PQQ-dependent-sugar-dehydrogenase
MLRVLAATIMRHGVLPALLAALAAPATAAQVASEPARADARVTEVADGLEHPWSLAFLPDGGMLITERPGRLRHLAPGGALSAPLQGVPKVAAQGQGGLLDVALSPDFARDRLVYLSYAEAGEDRSGTAVGRGRLSADLTRLDDFTVIFRQQPKLSRGQHYGARLVFDRQGFLFVALGENNDRPTAQDLDKLQGKVVRLHADGSVPADNPFAGRAGARPEIWSYGHRNPQGMALNPWNGQLWEHEHGPRGGDEINVVVRGANYGWPLATHGINYSGLPIPEAKGDTLPGGQEPLYWWRRSPAISGMAFYTSDRYPQWRGSLFIGALGSEELIRLQLDGERVVAEERLLGERKARIRDVRQGPDGGIYVLTDAAKGALWRVAPAAVSGGGS
>NZ_CP044089.1|WP_003811288.1|3893403_3894042_-|glutathione-S-transferase
MSTYELIGSRGCGSAIVEMALALANVPYTLTDLPYLKPGPGRDRLLSLNVTGQVPTLVLPDGEVMTESAAIVMHLHDVAPAAGLAPPPGSAERARFWNTLVRLVAGVYATFTYGDDPAKWTLPGDAAELLRTRVHDRRAQLWQEIERGAGAPHVLGRRFSALDLYVVVMTRWRPGPPWFQSVCPRLAAAARRAAEEPNVAQVLRRHFDPPLE
>NZ_CP044089.1|WP_003817609.1|3892506_3893391_+|DMT-family-transporter
MIATANTRAASPLVGIACVAVGIFCLTLSDAQAKWLGERYSPVQILFLRALIAMPVVLALTASLGGRRALRTQYPLVHLVRGAINVISATFFYLGLQALPLAENAAIAFAAPLFVTALSVLVLKERVDAARWLAVAAGFAGVLVIVRPGSASFQAAALWPLATALLYAVMMLTARAIGRGESMLTTMFYIVAGQLVCSAVAVAWFWTTPVWADLPFFAGVALFSTLGLTLITQGFRIGPASVVAPFDYTGLLWATLLGWLFWHETPDLLDCVGAAFIAGSGLYIAWRATSRRRS
>NZ_CP044089.1|WP_003811293.1|3892132_3892510_+|DUF423-domain-containing-protein
MTDRQLIVLAALNIMVAVGAGAFGAHGLRRVVDPTLLAIWHTGVLYHLIHALGLFVVALLGARFGSPLLSMAGLVMFIGILLFCGSLYVLVLTGTRWLGAVTPLGGVAFLAAWAMVAWAAWRAPA
>NZ_CP044089.1|WP_033460795.1|3891487_3891985_-|DUF2384-domain-containing-protein
MSIAIAEKSPARGAPKRRAPAARKRALEEEARVDSFADLVDSPLIAMAHGVQRGLSPRLLDDAADYLQVSKSEIMAITEVKAASLSRWMRDGQALPLGESDRLARVARVTKVARQVLGGDAEAVQWLNTPVPALGNVKPLSLLTSDASSRIVEDTLARAAAGVYA
>NZ_CP044089.1|WP_003817607.1|3890969_3891491_-|RES-family-NAD+-phosphorylase
MSHVSLWRIATTAGKYRADDLSGAGAAAVGGRYNSPGTAVVYTSSCVALAVLETVVHFAAPATAQANRYLIEIVVPRAVYEARQVLEVEALHKRHPFWDAVPFAEVSQRIGDAWVRGNGSALLQLPSAIVPCRGVPDCNLLINPQHPDAASVRVARREKFIYDPRLAPGGPRQ
>NZ_CP044089.1|WP_003817606.1|3890020_3890836_-|exported-protein
MRIRSGWMQWLGALALWCAAAGAGAAQQAPLRIGVIASVANEATEIAIAQARAQGLEVKLIEFNDWVMPNIAAAEGSIDANFFQHEPFLQLFNRSRGTRLTPIAYGYSTTIGLFSKKLKKGDAIPQGATIAVPNDPVNTGRALQLLASIGLIGLKPGAGHQATLQDVTDNPRGIKLVQLEGSQSARTFDDVTASVTYTTFAKHAGIDEKDGLAFDNTDPETVRRYAIRWVATPERAQDPRLLAFIRIYQSSPEVKATLRRLYGELIDFPWE
>NZ_CP044089.1|WP_033450462.1|3888799_3890008_+|alpha-hydroxy-acid-oxidizing-protein
MSSSALPLSAASAARPAVVPASLRKLLSLNDFEAAARRRLPRPIFGYVAGAAEDNHAHDDNRRAFAEYGFLPRVLVDVSARHTRTELFGQEWAAPFGVAPMGISALSAYRGDIVLARAARAAGIPAIMSGSSLIPLEEVARQAPGTWFQAYLPGDPARIDALVERVARAGYRTLVLTVDIPVSANRENNVRTGFSTPLKPGLRLAWDGLSRPRWLAGTFLRTLLAHGMPHFENSFATRGAPILSANVLRDFSARDHLDWSHVQRIRRSWRGELVIKGIMHPRDAALARAHGADGIIVSNHGGRQLDGACAPLRVLPDIAEAAGAMAVMMDSGIRRGGDVLKALALGARFVFLGRPFNYAAAVGGEAGVAHAIGLLREEIDRNMAMLGVTRCAAMAPGLLRRL
>NZ_CP044089.1|WP_003817613.1|3896964_3897666_-|ABC-transporter-ATP-binding-protein
MLKLENIHTYYGAIQALNGVSVEVKQGEIVTLIGANGAGKTTLLMTVCGNPRAREGVITFEGKDITHAETHHIMRSGIAISPEGRRVFKDLTVAENLMMGGFFSKREEVDAGLEHVYTLFPRLKERAGQRAGTMSGGEQQMLAIGRALMTQPRLLLLDEPTLGLAPLIIAQIFDIIRTIREQGVTVFLVEQNANKALQVADRGYVLENGRVVLHDTGANLLVNDQVRKAYLGG
>NZ_CP044089.1|WP_003811277.1|3897666_3898434_-|ABC-transporter-ATP-binding-protein
MSETLLKVSGLTMRFGGLLAVDSVAFEVRRDEVFAIIGPNGAGKTTVFNCVGGFYKPTAGEIVMDGKPITGMPSHKVARHGLVRTFQNVRLFKQLTVLENLLVAQHTQVEARLLPGLLKLKSYRQAEAEALTRAAQWLDFMGLREFANREAGNLAYGHQRRLEIARCMITKPRLLMLDEPAAGLNPQEKRDLQSLIDQLRREFGVAVLLIEHDMSLIMGISDRILVMEHGKPITTGIPDEVRNDPRVIKAYLGEE
>NZ_CP044089.1|WP_003817614.1|3898430_3899669_-|high-affinity-branched-chain-amino-acid-ABC-transporter-permease-LivM
MTQQSPLKNATIAAVMTAVIVTPIFGLQLVRQGARTLMEPRWDLVALACALVFAFQLLRPWISKPFKALKTGLPTLPSAPTRGHKWLVVLLIAVAVIWPFFSGRSSVDIATLVLIYVMLGLGLNIVVGFAGLLDLGFVGFYAVGAYTYALLYHWGGWSFWEALPFSGAVAALFGFVLGFPVLRLRGDYLAIVTLGFGEIIRLLLINLNTLTGGPDGISGLPKPSVLGMEMARRASTEGGQTFHEIMGWTFQNQHMVIYLYLMALALALATLFVSTRLIRMPVGRAWEALREDEIACRSLGLNPTRIKLSAFTLGAMFAGFGGAFFAARQGMVNPESFTFIESALILAIVVLGGMGSQIGVILAAILLTVLPELAREFAEYRMLMFGLVMVLMMMWRPQGLLPMKRPHVELRK
>NZ_CP044089.1|WP_003811272.1|3899668_3900595_-|high-affinity-branched-chain-amino-acid-ABC-transporter-permease-LivH
MSDLIPQLTQQFFNGLSLGAIYALIAIGYTMVYGIIGMINFAHGEIYMIGAYVGLVTLTAIGTNSGLPLPFIIAAMLVVAIFVTGVYGYSVERVAYRPVRGSPRLVALISAIGMSIFLQNWVALGQGARDMAVPALVSGAVQFHMGSSFDVTVPYSRIMIIVVTVVLMVALTLFIKYSRMGRASRACSQDMHMANLLGIDTNRVISFTFVLGAMLAAVGGVLIAITIGKLNPFIGFLAGIKAFTAAVLGGIGSIPGAMLGGVLLGLAETFAAAYISSQYKDIVAFALLVLILLFRPTGLLGKPEVEKV
>NZ_CP044089.1|WP_003811271.1|3900697_3901813_-|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein
MKFSQRFTPLAVALGALAFAGAVHAADTIKIGIPQPMTGPNTQYGDQIQAGALTAIETINAKGGVKGKKLEPILIDDGCEPKQAVPAANRVVNSGAKFAVAHACSGVTVAAVNVYEQEGIVAITPGATSPLVTDTIKPHFFFRTIGRDDQQGPFAARYIANTIKPKKVAVLHDKQTYGSGVATQVKDTLERNKVNVALFEGINVGDSDYSAIITKLKSAGVDFVYFGGYHPELGLLLRQAREQGLNVQFMGPEGTANQDLVAIAGPAIDGLLVTLPSDFTKLPGNEGVVKAFQDAKRDPDGAFQMPAYAAVQLLAESINAVGEDPAKVADHLHKNTFNTAIGKVEYDAKGDLKDFEFAVFKWDKNGKKTQL
>NZ_CP044089.1|WP_004566885.1|3902083_3902665_-|queuosine-precursor-transporter
MSPASRRYEPLRSGPFLLAVFCMGLVVVGSNILVQVPLNDWLTWGGLSYPVAFLVTDVLNRRYGPDAARRVAWFGFAAALAVSVWVASPRIALASGLAYLCAQLIDIRVFDRLRDQRWWRAPLISGVIAAVADTAVFFSVAFAGSDTPWVTWMLGDLAIKLAVNISMLAPFRALMWNLARPAEARPAQASTGR
>NZ_CP044089.1|WP_003817616.1|3902661_3903495_-|pyrroline-5-carboxylate-reductase
MKNDLSIAFIGGGNMAAALASGLAGKVCPAANIHVVDINADSHAGWRARGMSAAAAPDATLAGCRVWVYAVKPQHMREAVAGTRPWLRPDTLIVSVAAGIRADTLAGWLGEPGQPWQRLVRCMPNTPALVGAGMTGLAALPGVTPQDRELAGQLLASVGEVVWVDGDAGLDAVTALSGSGPAYVFLFIEALIAGGRAVGLTDEQARQLALGTLAGATRLAAQSDEPPAVLRERVTSKGGTTAAALDVYAQGDFAGLVERAMQAAARRSRELAEEFGR
>NZ_CP044089.1|WP_003811264.1|3903705_3905019_+|sn-glycerol-3-phosphate-ABC-transporter-substrate-binding-protein-UgpB
MRSQRLALTFAAVMAAFAGASAHAATEIQFWHSMEGALGDRVNGLVEEFNKQNADYQIKAVYKGNYGESMNAGIAAFRAGNAPDILQVFEVGTATMMYAKGAIKPVQQMSEEVGDPIDPKQFIGAVAGYYSSPEGKLVSMPFNSSTVVFYYNKDAFKKAGLDADKPPKTWEELAAAGQKLKAAGQECGYTTSWPSWVQLETFSAWHNVPYATKDNGFAGLDARLAVDTPLHVRHLDNLAKLAKEGIFMYGGRGDEPNSLFISGKCAMITGSSGLRANIAKNAKFEFGTSTLPYYSDVQGAPQNTIIGGASLWVFANKKPETYKGVTKFFKFLASPEIAARWHQQTGYVPVTKAAYELTQKQGFYDKNPGTDVGVKQLNVETTAQSRGLRLGYLPQIREIEDAEIERIVAGKVPAKDGLQSIVKRGNELLEKFEKSVK
>NZ_CP044089.1|WP_003817617.1|3905194_3906076_+|sn-glycerol-3-phosphate-ABC-transporter-permease-UgpA
MEKRVVFGHKTLPYLLLAPQIIITIVFFFLPAGQAMWQSLRLEDAFGLSSEFVGLANFADLFSQQSYLDSFRVTAVFSALVAFVGLAVSLLLAVMADRVLRGAGLYKTLLIWPYAVAPAVVGVLWLFLFSPSVGILAVALNGMGVNWNPRLDGDQALVLVLIAAVWKQISYNFLFFLAGLQSIPRSLIEAAAIDGASPARRFWTIVFPLLSPTTFFLLVVNIIYAFFDTFAVIDTTTQGGPGTATSILVYKVYSDGFRGLDLGSSAAQSVVLMAIVVALTVLQFRYIDRKVQY
>NZ_CP044089.1|WP_003811259.1|3906095_3906947_+|sn-glycerol-3-phosphate-ABC-transporter-permease-UgpE
MVERRPWLDILAHFILLCGVALVAFPIYVTFVASTQTAQEVASAPMSLIPGKHFVDNYMQALFAGSGGGSYGAPVGRMMYVSLIMALAISLGKIAISLLSAFAVVYFRFPGRMFFFWMIFVTLMLPVEVRIAPTYKVVADLGLLNSYAGLTLPLIASATATFLFRQFFLTVPDELVEAARIDGAGPMRFFRDVLLPLSRTSIAALFVIQFIYGWNQYLWPLLITTQEDMYPVVIGIKRMISGGDSVTEWNITMATAILAMIPPALVVILMQKWFVKGLVDTEK

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Crispr_ID: NZ_CP044089_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_9

4092523-4092608

Orphan

Consensus_repeat	Method
GTGTGCCTGTCCCGGCGGGAACAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_9

>merge|NZ_CP044089|9|4092523-4092608|CRISPRCasFinder
GTGTGCCTGTCCCGGCGGGAACAGATACCGCCTTGGCAGTCAACCGTTCATGGCGTAGCGCGGTGTGCCTGTCCCGGCGGGGACAG

>NZ_CP044089|9|8|4092523-4092608|CRISPRCasFinder
GTGTGCCTGTCCCGGCGGGAACAG	ATACCGCCTTGGCAGTCAACCGTTCATGGCGTAGCGCG
GTGTGCCTGTCCCGGCGGGGACAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_033839717.1\|4085777_4087382_+\|glycerol-3-phosphate-dehydrogenase/oxidase	unknown	unknown	gnl\|CDD\|223651
NZ_CP044089.1\|WP_003816584.1\|4095493_4096585_-\|exported-protein	unknown	unknown	gnl\|CDD\|270400
NZ_CP044089.1\|WP_003816583.1\|4094367_4095000_+\|7-carboxy-7-deazaguanine-synthase	unknown	unknown	gnl\|CDD\|275301
NZ_CP044089.1\|WP_004568506.1\|4093840_4094257_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
NZ_CP044089.1\|WP_003810921.1\|4089107_4089545_+\|carboxypeptidase-regulatory-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|379297
NZ_CP044089.1\|WP_010931059.1\|4092674_4093049_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226211
NZ_CP044089.1\|WP_003816564.1\|4082653_4083742_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226359
NZ_CP044089.1\|WP_015041400.1\|4098917_4100963_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|377393
NZ_CP044089.1\|WP_076879805.1\|4096639_4097440_-\|aldolase	unknown	unknown	gnl\|CDD\|180832
NZ_CP044089.1\|WP_033457134.1\|4097575_4098196_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380339
NZ_CP044089.1\|WP_003816581.1\|4093155_4093848_-\|DUF2238-domain-containing-protein	unknown	unknown	gnl\|CDD\|378345
NZ_CP044089.1\|WP_003810917.1\|4090645_4091590_-\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
NZ_CP044089.1\|WP_003816577.1\|4089635_4090607_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP044089.1\|WP_003810890.1\|4098447_4098921_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|179596
NZ_CP044089.1\|WP_014905911.1\|4091685_4092495_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
NZ_CP044089.1\|WP_003810899.1\|4095028_4095472_+\|6-carboxytetrahydropterin-synthase-QueD	unknown	unknown	gnl\|CDD\|376501
NZ_CP044089.1\|WP_003816566.1\|4083741_4084824_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226359
NZ_CP044089.1\|WP_003816571.1\|4087396_4088086_-\|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|153235
NZ_CP044089.1\|WP_003816574.1\|4088167_4089049_+\|NRDE-family-protein	unknown	unknown	gnl\|CDD\|377554
NZ_CP044089.1\|WP_003816568.1\|4084928_4085738_+\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182827

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_033839717.1\|4085777_4087382_+\|glycerol-3-phosphate-dehydrogenase/oxidase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	1.45132e-157
NZ_CP044089.1\|WP_003816584.1\|4095493_4096585_-\|exported-protein	gnl\|CDD\|270400	cd13682, PBP2_TRAP_alpha-ketoacid, Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; contains the type 2 periplasmic-binding protein fold. This subgroup includes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.81983e-167
NZ_CP044089.1\|WP_003816583.1\|4094367_4095000_+\|7-carboxy-7-deazaguanine-synthase	gnl\|CDD\|275301	TIGR04508, queE_Cx14CxxC, 7-carboxy-7-deazaguanine synthase, Cx14CxxC type. In the pathway of 7-cyano-7-deazaquanine (preQ0) biosynthesis, the radical SAM enzyme QueE is quite variable. This model describes a variant form in which the three-Cys motif that binds the signature 4Fe-4S cluster takes the form Cx14CxxC, as in Burkholderia multivorans ATCC 17616. The crystal structure is known.	3.92904e-136
NZ_CP044089.1\|WP_004568506.1\|4093840_4094257_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	1.35747e-65
NZ_CP044089.1\|WP_003810921.1\|4089107_4089545_+\|carboxypeptidase-regulatory-like-domain-containing-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	0.00135235
NZ_CP044089.1\|WP_010931059.1\|4092674_4093049_-\|hypothetical-protein	gnl\|CDD\|226211	COG3686, COG3686, Predicted membrane protein [Function unknown].	8.27238e-19
NZ_CP044089.1\|WP_003816564.1\|4082653_4083742_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	7.16154e-120
NZ_CP044089.1\|WP_015041400.1\|4098917_4100963_+\|FUSC-family-protein	gnl\|CDD\|377393	pfam04632, FUSC, Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, FusC from Burkholderia cepacia and fdt-2 from Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.	1.65628e-173
NZ_CP044089.1\|WP_076879805.1\|4096639_4097440_-\|aldolase	gnl\|CDD\|180832	PRK07090, PRK07090, class II aldolase/adducin domain protein; Provisional.	6.37491e-166
NZ_CP044089.1\|WP_033457134.1\|4097575_4098196_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.59358e-16
NZ_CP044089.1\|WP_003816581.1\|4093155_4093848_-\|DUF2238-domain-containing-protein	gnl\|CDD\|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	1.33959e-64
NZ_CP044089.1\|WP_003810917.1\|4090645_4091590_-\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	6.63687e-70
NZ_CP044089.1\|WP_003816577.1\|4089635_4090607_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	2.30432e-133
NZ_CP044089.1\|WP_003810890.1\|4098447_4098921_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|179596	PRK03573, PRK03573, transcriptional regulator SlyA; Provisional.	5.11244e-19
NZ_CP044089.1\|WP_014905911.1\|4091685_4092495_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.32527e-54
NZ_CP044089.1\|WP_003810899.1\|4095028_4095472_+\|6-carboxytetrahydropterin-synthase-QueD	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	2.78822e-38
NZ_CP044089.1\|WP_003816566.1\|4083741_4084824_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	5.09179e-108
NZ_CP044089.1\|WP_003816571.1\|4087396_4088086_-\|type-1-glutamine-amidotransferase-domain-containing-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	3.27534e-99
NZ_CP044089.1\|WP_003816574.1\|4088167_4089049_+\|NRDE-family-protein	gnl\|CDD\|377554	pfam05742, TANGO2, Transport and Golgi organisation 2. In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.	5.33506e-86
NZ_CP044089.1\|WP_003816568.1\|4084928_4085738_+\|DeoR-family-transcriptional-regulator	gnl\|CDD\|182827	PRK10906, PRK10906, DeoR/GlpR family transcriptional regulator.	2.996e-88

>NZ_CP044089.1|WP_014905911.1|4091685_4092495_+|IclR-family-transcriptional-regulator
MKNIPASAPRDTAQSLRRSIEILKALSAPMKRGFSLSELSRMTGLPHPTVLRLLRHLTGLGMVAWDPATKIYRLGTLTFELGLAAAEHCDIRGLCGDSLDRLQAETQDTCYLTMRSGFDAVCIDRREGASPIRVLTLDIGSRRPLGVGAAGLAILDCLPEEEAETVIQASESKLDRYNRMSTDIMRMLLQETRERGYAVCGNWVTLGVTAVAVPICIEDGRPIGSLSVSAVSHRMPADRWPGIARALRAEMHEIHRKLQGPSSRPGYGG
>NZ_CP044089.1|WP_003810917.1|4090645_4091590_-|dihydrodipicolinate-synthase-family-protein
MAARFPGYVPAGVIPAALMPFNEDLSIDEKSLRAHIRDLASVRGISALCVNGVSQEIPGLTLDEQRRALDVMADEVGDQVPLMHGVYAHGPLDAARIARQAEAGGASCLLVFPPAVFARGAAMLPEMTLGHYKAIADATDLPLIVFQYETSTGMAHPLDTLVKLAEAVPSVMAIKDRSNNPIEHERNIRVLQSLARPVNVLTTHSAWLMPSLVLGCNGILSGSGSVHADLHVALWEAVQANDLAAARAINDQIYPMASCFYSAPTLDMHTRMKEALVMLGRLPSGRVRLPWVDLSDAERARVRAALVQAGRLPA
>NZ_CP044089.1|WP_003816577.1|4089635_4090607_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MRVMQKGLMAALLLGSAFASAAAADSFPQRPVTIVVPFTPGGAVDIVARTVAAGLSEQWSQSVVVENKAGAGGAIGIQSVARAKPDGYTLLLGSVGPVTVNPSLGPVGYDVAKELAPVVLLAKTPAVLVTLPSAPVDDVAQFVKQAKAQPGGLNYGSAGTGNITHLVSEYFLSSAGLAANHIPYKGSAPAITDMLGGRLDFMFDVVPTAQPLIKSGKYKALAVTTIKRSDVLPDVPTLDELGYKGFDVSSWFSLMAPAGTPDAVIGQINAAVNEVLRSDASRERLAAIGAYSAGGTPEQLGEFVRSETARWKKLIDERGIRAN
>NZ_CP044089.1|WP_003810921.1|4089107_4089545_+|carboxypeptidase-regulatory-like-domain-containing-protein
MNKRHERAWMAAALAAGSIALGGAVQAQGALPAVQQQGSVQFVTGGVGLDESEAMKAASKDYPLALTFAARGDGRAGLYLADVAVQILDRTGKPVLDAKADGPYLLAKLPAGTYRVKATSGGVEQTRQVSVRPGSTARAVFEWKD
>NZ_CP044089.1|WP_003816574.1|4088167_4089049_+|NRDE-family-protein
MGKTQEFLRLRRIIALSSLLASRKSAMCLAVLALHAIPGLPVLIAANRDEFHARPTAEATRWPGSPAIYAGRDLQAGGTWMGVSDQGRYAVVTNFRDPRNIQPDAPSRGALVEAFLRGAASAQEYLHDVHARGARYNGFNLIVGDAGGAWYCSNRDGAPRRLAAGVYALSNHLLDTPWPKLARTKAAFERIIAAAPQPDLAALYAALADPTPAADHELPATGLALERERLLSSPFIVSPDYGTRSACILALHDDGRGELHERRFRPDGAIAGQTDLDFPWRAAHAELHRASCV
>NZ_CP044089.1|WP_003816571.1|4087396_4088086_-|type-1-glutamine-amidotransferase-domain-containing-protein
MKILMVLTSHDQLGDTGRKTGFWLEEFAAPYYVFVDAGARVTLASPAGGQPPLDPKSDEPDAQTEATRRFAADTQAQQALAHTAKLADMRAADFDALFYPGGHGPLWDLAESAHSTALIETFLAGGKPVAAVCHAPGVLRHARAADGAPLVAGRQVTGFSNTEEAVVQLTEVVPFLVEDELVGLGARYSKAEDWHAYVVNDGLLITGQNPASSERAARAMLTALDNGRG
>NZ_CP044089.1|WP_033839717.1|4085777_4087382_+|glycerol-3-phosphate-dehydrogenase/oxidase
MTAPTLAPIDPPARAQLLADLQGAPDWDVIVIGGGATGLGTAVDAAARGYRTLLVEAADFAKGTSSKATKLVHGGVRYLAQGNISLVREALHERGLLNRNAPHLVWPLGFVVPAYSLLDQPFYGVGLKMYDMLAGKLNLAPSRWLSRGETLRHAATVAERVNGRALRGGILYYDGQFDDARLAIALMRTLYDLGGVALNYARAVGLTRTDGRVDGVTVADALGELRVTLRAKCVVNATGVWVDAVRRMDDPAAQTMVAPSQGVHLTLPRDFLPGEDAILIPKTDDGRVLFVVPWNGHTIVGTTDTPRTDLPLDPQAGQNEIDFILATAARYLSRKPTRADVTSVWAGLRPLVKATGEASTKSLSREHTIVVSKGGLVTVTGGKWTTYRKMAQDVVDTAIEHKLLAAAPCRTSELPLHGAPADGQPNSAPHGTPDSYYGTDLATLRALPGADRMLVKASALTEAHVRYAARHELARTVEDVLARRNRALFLDAEAALLAAPEVARILAQELGHDEAWSRATLAEFEAVAAHYRLA
>NZ_CP044089.1|WP_003816568.1|4084928_4085738_+|DeoR-family-transcriptional-regulator
MLFYDASMTLNPRQSALVELVRTQGSATIEALARHFDVTLQTVRRDVNLLSEAGMLSRFHGGVRIESSTIENIAYRKRQGLHAEGKRRIAEAVARAVPDGCSLLINIGTTTEAIARALLRHRGLRVITNNLHVADILSDNPDCEVIVAGGVVRSRDRGIVGEATLDFIRQFKVDIGLIGISGIEADGTLRDYDFREVRVARAIIEQSREVWLAADSSKFQRQAMVELVHVSRIHRFFTDAQPQESLAQVLQDAGVRCDVAAQSAGAAAA
>NZ_CP044089.1|WP_003816566.1|4083741_4084824_-|ABC-transporter-ATP-binding-protein
MQLVLDGIQLRAGSQVHLYPLSLQPAPGAMTVLLGATLAGKTSVMRIMAGLDRPTEGKVLVDGADVTGVPVRQRNVAMVYQQFINYPSMRVADNIASPLRLRGAADIPARVRAMAERLHIEHLLDRYPSELSGGQQQRVALARALVKDAPLVLLDEPLVNLDYKLREALREELAGLFAQGRSTVVYATTEPAEALLLGGHTAVLDAGRLLQYGPTAEVFHRPNSIRVARAFSDPPMNLFPARRANGGFMLASGVMVPCALPPPETGDDALTAGLRAGVFRTEARGADVALPGVVELAEISGSDSFVHVRTPAGPVVAQLTGVHRYPLDSRLTLHFDPADSYAFGPDGALLAAPRRAGGER
>NZ_CP044089.1|WP_003816564.1|4082653_4083742_-|ABC-transporter-ATP-binding-protein
MASIELDLAHAYGPDPRGEDDYALLPLRFTFEDGGAYALLGPSGCGKTTLLNCVSGLLRPSQGRVLFDGQDVTGRTPQQRNIAQVFQFPVVYDTMTVADNLAFPLRNRGVPQAHIRERVGRIAEMLELSAVLERRASGLTADAKQKISLGRGLVRSDVSAILFDEPLTVIDPHLKWELRRKLKEIHHEFKLTLIYVTHDQTEALTFAERVMVMSRGRAVQVGTPDDLFERPAHTFVGHFIGSPGMNFLPAEWRDGALRIGSQRLEGLTAGQAEALAQGGPVKLGVRPEYLRLVAPHTPGALPVRVARVQDVGTYALLGAEFESIALRARLPLDAALPGAGDTVWLAVLNRHTCFYRDEELIR
>NZ_CP044089.1|WP_010931059.1|4092674_4093049_-|hypothetical-protein
MNATAAFLLAAALLPLVPAIAAKAGGRRYDNNDPRPWLAGQAGWRARANSAQANTFEALPFFFAAVLYALHTQAPAATLHVLMGAWLVARLVYVALYIGGRGNLRSLIWLAALLVNVAILLAGS
>NZ_CP044089.1|WP_003816581.1|4093155_4093848_-|DUF2238-domain-containing-protein
MTEARAGLFARRRYLPALAVLYAALWLALAIEPHDRSDWLLENALVLGFGVALYATRRWFVFSRVSYTLIFLYLCLHAVGAHYTYSLVPYDAWWQRLTGHSLDQLLGWERNQFDRLVHFSYGLLLAYPIREIFLRVVEVRGFWGYLLPLDVALSTSALYELIEWGAAEFFGGELGVAYLGTQGDIWDAQKDMALAGLGALIAMLLTALFNRGARRDPARDWVDRMKPGHT
>NZ_CP044089.1|WP_004568506.1|4093840_4094257_-|aminoacyl-tRNA-hydrolase
MLHVLGSLYLDERELDFDMIRAQGAGGQNVNKVSSAIHLRFDVRASSLPESVKETVLALADRRISSDGVIVIKAQTHRSQEKNRADAVERLLALLREALRPVRPRRATRPTLGSQRRRVQRKVQHGETKRLRGRVRDD
>NZ_CP044089.1|WP_003816583.1|4094367_4095000_+|7-carboxy-7-deazaguanine-synthase
MAYSVKELFKTLQGEGAQAGRAAVFCRFAGCNLWTGRESDRAGAACTFCDTDFVGTDGQGGGKFADAAGLADAIAACWGDHPADRYVVFTGGEPLLQLDEALLQAVHAQGFTVAIETNGTLPPPPGIDWICVSPKGRAPVVVERGHELKLVFPQADARPEAFAHLAFEHFFLQPMDGPARAAHTAQAVQYCLDHPQWRLSLQTHKYIGIP
>NZ_CP044089.1|WP_003810899.1|4095028_4095472_+|6-carboxytetrahydropterin-synthase-QueD
MISVTRRLEFDAGHRIPDHNSQCRNLHGHRYVLEVTLSGDVVQAPGASDNGMLMDFSEIKRIARTHIVDVWDHAFLVYEGDHAVRGFLDTLPDHKTVVLDRIPTAENLASIIFATLAPHYHGHYGADLRLTRVRLYETPNCWADCGS
>NZ_CP044089.1|WP_003816584.1|4095493_4096585_-|exported-protein
MQRRRFLTAAAAGAGSAVLAAPAVAQEAPTIRWRMPSSFPRSLDTVWGAAEAITARVSELTDGKFAIRAFPAGELVPPLQVLDAVQNGTTECGHTAGFYYMGKEPALVFDTGVPFGLTPRQHSAWVLQGGGQALIDELYAGFNAIAIPCGNTGAQMGGWFRKQMRTPDDFKGLRIRTPGLLSMVYQKLGAIPQQIAGSDIYPALEKGSLDAVEFVGPYDDEKLGFAKVAQYYYGPGVMELGANLCLNVNRESWQSLPPRYQVALRAACAMAGEELLAKYDAHNIPALKRLVGQGAKLQSWSPEIMAAMQKATREVLEEYAGKNPRFAKVLESWRAFRADQLLWASVNDGAAERYLLATRENGL
>NZ_CP044089.1|WP_076879805.1|4096639_4097440_-|aldolase
MESMMSSSYTVQDKDVLRARVDREIESRVSEPQWTRAQKMALACRMLAEQGHWHGGLAGQITARGDEPGTYWTLPFGVGADEARASELILIDEDLNPLDGKSLPNPANRFHIWIYRHRPNVQCIVHTHPPAVSALSMVGEPLVVAHMDATPFYNDCAYLPQWPGLPIGDNEGEVISAALGEKRAILLANHGLLTAGSSIEESAVMALWMEQAAMLQLRARAIGPVKAVPGELAQESHDFLVKPKIQSLTFAYFARRVLRAAPDCLD
>NZ_CP044089.1|WP_033457134.1|4097575_4098196_+|XRE-family-transcriptional-regulator
MASCVLTHSPPPPMTAKSPPIPAPSPEQIGLRIRALRKRQKRTLAWLSAQCGLDKGFLSRLERGEKSASVGTLHTVAGALGSSLSALLGEADPQTEIQIVRAADRHRMTTAPGPGEHIYEAITLGSAHSGLSVMVVEVGTHGAHTEAHHGGDELIFVLDGRIRVHFGGHTVLLERDDSVRFPGYLPHSLSAEGRKLARALVVIASG
>NZ_CP044089.1|WP_003810890.1|4098447_4098921_+|MarR-family-transcriptional-regulator
MKTATDNRLMAMTANLMVLSRAYRSAADKALADFGLSQATAWPVILTGRLGDGVRQGALAEALGVEGPSLVRVLDQLVAAGLIERREDPQDRRARTLHLTPAGQSLREQVENVLVQLRRQLFQGIADADLETCLRVFDSLKSALGRESAAAREDYRP
>NZ_CP044089.1|WP_015041400.1|4098917_4100963_+|FUSC-family-protein
MKLPTADEAVFSIKCYLGAMLALYLAYSIGLPRPFWAMTTAYVVAQPWSGAVRSKAVYRLGGTFFGSAMTIYTVPRLANYPVLMTLAMVLWVGLCLYIAVLDRTPRSYLFMLAGYTAAMIGFPSVTDPALVFDTALARVEEISLGIICATLVHSVVLPRGIGRAMMGRLDATVRDARSWIQDVLNQRGAAQHARDRRTLANDITQLRLLSTHVPFDTGNIRWTANALRAMQEHITALTPAVSAVEDRLQALQAQGRALPPPAARVLADISAWMDDSAHATREQAVQLRAALTRLAPAIDRQSGWHDALLASLVARLRELVDSYDACLVLRQDIHAGLGGAPTGRTRRLTRGAALHRDHGLALLSALAAALAISVCCLFWIGTAWTNGATAAMMAAIFSCFFAAQDNPVPGIMQFLTYTIYSIPLSALYLLGIMPALHSFEMLALAIFPVAFVTGVYIARPTTTGKAMAVFFGLSGTLALQDTHAADLVSFVDTIVAQIIGVAVAAIIAAVFRTVSAEWSARRIQAANWKELAALAGAGRAPARLDFTARMLDRIGLLQPRLALSKRRDDQLADDALQDLRVGKDIAELQRARRHLPMADPAIQPVLRTLAGLFRKRPGRLGGERPAELLQTIDRALYSVSNTPVAHAARERAVVALVGLRRAFFPEAAAYRPGRDVESPAS

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Crispr_ID: NZ_CP044089_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_10

4541903-4542002

Orphan

Consensus_repeat	Method
CAGGATTCGGCAGGTGCCTGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_10

>merge|NZ_CP044089|10|4541903-4542002|CRISPRCasFinder
CAGGATTCGGCAGGTGCCTGTCCTCGCGGGAAGGACCAGGATTCGGCAGGTGCCTGTCTCCGCGGGGGACAGGCACCCAGGATTCGGCAGGTGCCTGTCC

>NZ_CP044089|10|9|4541903-4542002|CRISPRCasFinder
CAGGATTCGGCAGGTGCCTGTCC	TCGCGGGAAGGACCAGGATTCGGCAGGTGCCTGTCTCCGCGGGGGACAGGCACC
CAGGATTCGGCAGGTGCCTGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_033453839.1\|4526903_4529294_+\|3-hydroxyacyl-CoA-dehydrogenase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|224170
NZ_CP044089.1\|WP_033462175.1\|4542663_4543695_-\|2,5-dihydroxypyridine-5,6-dioxygenase	unknown	unknown	gnl\|CDD\|225191
NZ_CP044089.1\|WP_010929891.1\|4544562_4545315_-\|maleate-isomerase	unknown	unknown	gnl\|CDD\|226004
NZ_CP044089.1\|WP_004568017.1\|4532751_4534317_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|293752
NZ_CP044089.1\|WP_003820181.1\|4525528_4526833_+\|outer-membrane-beta-barrel-protein	unknown	unknown	gnl\|CDD\|367457
NZ_CP044089.1\|WP_110128934.1\|4542030_4542648_-\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238497
NZ_CP044089.1\|WP_003820162.1\|4551072_4551849_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213186
NZ_CP044089.1\|WP_150349124.1\|4538172_4539579_-\|ferric-reductase	unknown	unknown	gnl\|CDD\|226582
NZ_CP044089.1\|WP_033453837.1\|4536053_4538162_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|236643
NZ_CP044089.1\|WP_003820177.1\|4530499_4531048_+\|DUF4442-domain-containing-protein	unknown	unknown	gnl\|CDD\|373120
NZ_CP044089.1\|WP_150349125.1\|4543722_4544544_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP044089.1\|WP_014905577.1\|4545615_4546767_+\|6-hydroxynicotinate-3-monooxygenase	unknown	unknown	gnl\|CDD\|181262
NZ_CP044089.1\|WP_004568018.1\|4535392_4535920_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP044089.1\|WP_003820161.1\|4551845_4553795_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323
NZ_CP044089.1\|WP_080704947.1\|4547361_4550211_+\|c-type-cytochrome	unknown	unknown	gnl\|CDD\|224446
NZ_CP044089.1\|WP_015041303.1\|4534333_4535299_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270297
NZ_CP044089.1\|WP_003820163.1\|4550302_4551076_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213191
NZ_CP044089.1\|WP_003820178.1\|4529303_4530503_+\|acetyl-CoA-C-acyltransferase	unknown	unknown	gnl\|CDD\|181626
NZ_CP044089.1\|WP_010928484.1\|4546843_4547365_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP044089.1\|WP_003820175.1\|4531056_4532730_+\|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl\|CDD\|235923

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_033453839.1\|4526903_4529294_+\|3-hydroxyacyl-CoA-dehydrogenase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	1.3401e-81
NZ_CP044089.1\|WP_033462175.1\|4542663_4543695_-\|2,5-dihydroxypyridine-5,6-dioxygenase	gnl\|CDD\|225191	COG2309, AmpS, Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism].	4.5715e-07
NZ_CP044089.1\|WP_010929891.1\|4544562_4545315_-\|maleate-isomerase	gnl\|CDD\|226004	COG3473, COG3473, Maleate cis-trans isomerase [Secondary metabolites biosynthesis, transport, and catabolism].	1.92629e-83
NZ_CP044089.1\|WP_004568017.1\|4532751_4534317_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|293752	cd16028, PMH, Phosphonate monoester hydrolase/phosphodiesterase. Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.	0
NZ_CP044089.1\|WP_003820181.1\|4525528_4526833_+\|outer-membrane-beta-barrel-protein	gnl\|CDD\|367457	pfam03349, Toluene_X, Outer membrane protein transport protein (OMPP1/FadL/TodX). This family includes TodX from Pseudomonas putida F1 and TbuX from Ralstonia pickettii PKO1. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.	1.91353e-111
NZ_CP044089.1\|WP_110128934.1\|4542030_4542648_-\|isochorismatase-family-protein	gnl\|CDD\|238497	cd01015, CSHase, N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.	7.83696e-78
NZ_CP044089.1\|WP_003820162.1\|4551072_4551849_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	3.01527e-110
NZ_CP044089.1\|WP_150349124.1\|4538172_4539579_-\|ferric-reductase	gnl\|CDD\|226582	COG4097, COG4097, Predicted ferric reductase [Inorganic ion transport and metabolism].	2.68702e-89
NZ_CP044089.1\|WP_033453837.1\|4536053_4538162_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|236643	PRK10044, PRK10044, ferrichrome outer membrane transporter; Provisional.	1.58872e-163
NZ_CP044089.1\|WP_003820177.1\|4530499_4531048_+\|DUF4442-domain-containing-protein	gnl\|CDD\|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	1.89152e-11
NZ_CP044089.1\|WP_150349125.1\|4543722_4544544_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.98017e-19
NZ_CP044089.1\|WP_014905577.1\|4545615_4546767_+\|6-hydroxynicotinate-3-monooxygenase	gnl\|CDD\|181262	PRK08163, PRK08163, 3-hydroxybenzoate 6-monooxygenase.	1.20905e-73
NZ_CP044089.1\|WP_004568018.1\|4535392_4535920_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.58816e-15
NZ_CP044089.1\|WP_003820161.1\|4551845_4553795_-\|ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	2.4501e-69
NZ_CP044089.1\|WP_080704947.1\|4547361_4550211_+\|c-type-cytochrome	gnl\|CDD\|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	4.25194e-17
NZ_CP044089.1\|WP_015041303.1\|4534333_4535299_-\|hypothetical-protein	gnl\|CDD\|270297	cd13579, PBP2_Bug_NagM, Uncharacterized NagM-like protein of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	7.18908e-127
NZ_CP044089.1\|WP_003820163.1\|4550302_4551076_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213191	cd03224, ABC_TM1139_LivF_branched, ATP-binding cassette domain of branched-chain amino acid transporter. LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.	5.77928e-111
NZ_CP044089.1\|WP_003820178.1\|4529303_4530503_+\|acetyl-CoA-C-acyltransferase	gnl\|CDD\|181626	PRK09052, PRK09052, acetyl-CoA C-acyltransferase.	0
NZ_CP044089.1\|WP_010928484.1\|4546843_4547365_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.54218e-61
NZ_CP044089.1\|WP_003820175.1\|4531056_4532730_+\|long-chain-fatty-acid--CoA-ligase	gnl\|CDD\|235923	PRK07059, PRK07059, Long-chain-fatty-acid--CoA ligase; Validated.	0

>NZ_CP044089.1|WP_150349124.1|4538172_4539579_-|ferric-reductase
MHNGPGANGRLRKRHRARSGDAMRRLRTIFILLVAALSVLWLSQNPPGAWGEGFWAMRKPLIYYTGILALGMMSLGVILATRPARFEGALGGLDKFYRLHKWLGLGGVALALTHWLLKIVPPWMAAQGWTVRPPRVPAPAGQAALYDPFQAWHGVAKSLGEWGLYALLLLAALALYKRFPYRHFFRTHRLMPALYLVFVFHAVVLMAPAYWRGPIGPVMAVVMAAGGAGALLSLLGLIGRPRQAAGRIARLERFADNAVMQVDVQLETRWPGHRAGQFAFVTFDRAEGAHPFTISSAWRDDGLLRFSIKGLGDYTRSLPARLRVGDGVTVEGPYGRFDFRANGRPQILVAGGIGITPFLARLQDMAAARSEGAPAHEVDLVYSTNAPDPDFIGELRALAERARVGLHVLVTQRDGKLTAERLVDMLPRAAQSEVWFCGPAGFGQALREGLAARGMPPACFHQELFEMR
>NZ_CP044089.1|WP_033453837.1|4536053_4538162_+|TonB-dependent-siderophore-receptor
MHTRTQQRRRPAAPRLLHLSLAASLAAGAAQAQTATEATTLPTVQVTGRGETATGPVDGYAATRSATATKTDTPLSETPQAVTVIPREQIIDQGAQNVQDTMNYAAGVRPNAYGVDNRGDYVRVRGVEPVQYLDGLKQFFNYNNPRTEVYGLERVEVLRGPASMLYGQGSTGGVVNLVSKRPQPEAMREIGVTVGNHNRKEIQADLTGPLTEDGTWLYRVVALGRDSDTQVQYTKDDRMMVAPSLTWQPSAATSLTLQAYWQKDKSGTTQAFLPWSGTVSGNPNGRIPTRRFTSEPGFDRYDTEQFSVGWQFEHKFNDNWKVRQNLRHTSSKVDYSTLYPAVYGNPDNPFIDADQRVVNRYLYIKNPRMRSLLADQNLEGKVNWGRAEHTLLMGVDYSRYRETGETGSGFGAPLDLYQPVYGTLPDYAMSDVPKNKQQQIGVYLQDQIKFDRNWIVVAGLRHDRVANSVEGADKETDNATTKRLGLMYAADNGWSPYLSYSESFTPIAGTDNSGNRWVPMRGKQWEAGLKYMPQDTGYEATLAAYDLRERNRQTNDPSDPTNQVQTGKTKTRGIELEFRGRVTPQMDVIANYNYTDIDPQLEGLPKHTFSLWSKYRFSVGDVHGFAAGAGVRYLNAFRDGSAPETGSVALFDAMLSYDTGSWRYALNVANIADKTYEVVCLRRGDCFYGQRRTVTLSAMYRF
>NZ_CP044089.1|WP_004568018.1|4535392_4535920_+|winged-helix-turn-helix-transcriptional-regulator
MSRPAACLQDMLMYRLYQAWSQSNPVFVRLCEGRYGITRREWRILAAAVEHGRMTSAALAAAASLDLVRTSRTVGALCRKGWLQREHGLSDRRVVHIEATEAGLAHYQAVLPAVAQLNDLLAESLDPAEIDQLRDLLARIEARGRAMAAGNLIAEKADRRAGGTRRRRETGPPPR
>NZ_CP044089.1|WP_015041303.1|4534333_4535299_-|hypothetical-protein
MFKSMLAAVLALGMSGPAAQAAAPLDGPLTIVVGYAPGGSSDRIARLVAERLKDRVGVPVIVENKTGAGGRIAAQALRQASAQQNVLMLANPAVMVVAPLVYAQPGYDAQRDFQPLSLASRYKFALAVPAGSPLRTLADLRQWIAAHPKQLTVGVPATGSLPHFFALMLGREVGEDVEVVGYRGSGPLITELIGGILGQGIDTLDTLLPQHQAGKLRILATSGQTRDAQLPDVPTFREAGVDLAADGWNAFFAPAAMPADKVERLGRDIAAVMSEPAMQQAVRAVNLEPVAQDAAQTAASLQAYRDQWEPVVRQSGFTATQ
>NZ_CP044089.1|WP_004568017.1|4532751_4534317_-|sulfatase-like-hydrolase/transferase
MTQVQNVLFIMADQLRADHLGCYGHPYLRTASLDALARRGVRFERAFVNSGVCGPSRMSYYTGRYPSSHGATWNRVPLSVGEVTLGEYLAGHGLDLALAGKTHVLPDAAGMQRLALDGGSELGLLLSRGGFRELDRYDGHHEPGAESGYPAFLRRHGYDSPDPWSDYVISAIDAGGQVVSGWHMRNTYLPSRVREAHSETAYMTGQALDFMRQRGGQPWVLHLSYVKPHWPYMAPAPYHSMYRPEQCLPVLRTAAEREDAHPVVQAYRQHEESLSFARDDCVRIVRPAYQGLIQQLDDHLGRLFDYMEGAGLMRNTLVIFTSDHGDFLGDHWLGEKELFYDTVQRVPLIVMDPSPAGDAVRGTVSDKLVEGVDIVPTILQALEVPLPTHRIEGRALQPLLHGETQAPWRDCVFSELDYSFRQARLLRGKTPQQARAWSARTDRWRYVYWQDEPEQLYDLANDPGELQDLGRCPAHEAVRAEMRARLLEWSLGRKTRVTIADSAIERSTNAHKRAGIHFGQW
>NZ_CP044089.1|WP_003820175.1|4531056_4532730_+|long-chain-fatty-acid--CoA-ligase
MEKIWLASYPAGVAPEIDSGAHASLAEVIEDSCRTFAGKTAYISLGRTLSYAGLDHRSRAFAAWLQARGLGRGERVALMMPNLLQYPICLFGAWRAGCTVVSCNPLYTPRELAHQLADSGARAIVVADNFAATLQQALPQTALEHVVVTSIGEQLGWPRGPVVDFVVRRVKRMVPAWSLPGARRLRDVLAEGERLPHAAPALGHADLACLQYTGGTTGVAKGAMLTHGNLIANLCQAHAWVRPLVKEGRECVVTALPLYHIFALTANCLTFLKIGASNLLIVNPRDIPAFVRELRKTPFSCITGVNTLFNALLDHPGFARLDFSRLRLTLGGGMAVQRSVAERWRAVTGKPLAQAYGLTETSPAVTINPLDAPVFTGSIGLPVPSTELSIRDEQGKELPLGETGEICVRGPQVTPGYWQRPDETALSFHADGFLRTGDMGYVDPQGYVFLVDRKKDMILVSGFNVYPNEIEDVVALHPGVREVAAVGVPDARSGEAVKLFVIRKDPDLDAAALIAYCRANLTGYKVPRSVEFRTELPRTNVGKILRRQLRDEAGRPA
>NZ_CP044089.1|WP_003820177.1|4530499_4531048_+|DUF4442-domain-containing-protein
MKLQWIERVPPRWRARLLRVGFNLHPAFRATGGRVVEIAADFLHIRIRLPLGRRTRNIVGSMYGGSLFSVTDGAHPTMLMMALGPGVIVWDKAATIRYRKPAYATLYADFRIGRDEIAAIRAELARDHETTRTYSVALSDRHGEVYAVVERTVYIADKAFYKRKTQAGAPARTPLEPAPPGN
>NZ_CP044089.1|WP_003820178.1|4529303_4530503_+|acetyl-CoA-C-acyltransferase
MSKQIQDAYIVAATRLPVGKRNGAYATTRPDDMLAAVLQAALAQVPALLPERIDDVITGCAMPEAEQGMNVSRIGLLLAGLPQSVAGVTVNRFCASGLQAVADAANRIRLGMADVMIGAGTESMSAMPQIMGNKVAMNPAVFAHEENLGMAFGMGLTGEKVAEQWKVSREDQDAFSLSSHQKACAAIAAGHFKAEITPYQVRTHLAGGRDGAVRVAERWIEQDEGPRPDSTAEALARLRPVFAARGSVTAGNSSQMSDGAAAVVLVSERVLREYGLQPLARFVDFAVAGVPPEIMGIGPRMAIPKVLARSGIAQQDLDWIELNEAFAAQSLAVMRDLELDPAKVNPLGGAIALGHPLGATGAIRTATIVHGLRRTGGKYGMVTMCIGTGMGAAGIFEAL
>NZ_CP044089.1|WP_033453839.1|4526903_4529294_+|3-hydroxyacyl-CoA-dehydrogenase/enoyl-CoA-hydratase-family-protein
MSKFVVKQAAVLGAGVMGAQIAAHLANAGVPVMLYDLTAPQGERNAVVHKALAGLRKLEPAPLARPDRLALITPANYDDDLERLGGCDLVIEAIAERLDWKTDLYHRIAAHVAPHAIVASNTSGLSIETLAGALPEALRPRFCGIHFFNPPRYMRLVEIIATRHTRPEVVDQLEGWLTSRLGKGVIRALDTPNFVANRIGVFSILAAMHHTQRLGLGFDEVDALTGPKIGRPKSATYRTADVVGLDTLAHVVATMRDNLPDDPWHAYFELPAWLQALIDQGALGQKSGAGVYRKAGKEIQVLDPASGQYRPSAGALADETAAILKERDPARRLAQLRASAHPQAQFVWSLLRDIFHYSACQLAGVADNARDLDLAMRWGFGWAQGPFETWQAAGWQDTARAIAEDIAAGRAMSAAPLPDWALDSGRTGVHTPQGSYSARDGQLRPRSALPVYRRQLFPEKLVGESPAPRGETVWEAPGVRLWRLPEQDGGIAILSVTSKMHTIGEEVLDGIQQAIARAEREFDALVMWHDAPFAVGANLEQVYQACAAGEFERLEATVEQFQRTSLALARAQIPTVVAVQGMALGGGCEFIMHASHRVLALESYIGLVEAGVGLIPAGGGSKALAVRAARLAAATATPAEVFPYLQPVFQNIATAQVAKSALQAMDMGYAHDGDTVVFHPDELLWVALRQARAAADSGHAPAPAPRDIPVAGRTGIANFEMVLVNMREGGMISAHDYRVARSAAVALCGGEVEAGTRVDEQWLLAVERREFMALLRTPETQARIRHTLDTGKPLRN
>NZ_CP044089.1|WP_003820181.1|4525528_4526833_+|outer-membrane-beta-barrel-protein
MNGRSVTLKTLVAALAGLTAGAAHSAGFQLLEQNASGLGNAYAGSAANPENASIIYFNPAGMTYLPGVNVSGGVNAIWPSFKFSDNGDSRDPTLLGGGRPAGGNGGDAGSLGVVPNAYVSWQVADQWWLGLGMGAPFGLMTKYDSGWAGQYHSNKFDIKTININPSIAYKVNDRFSMGFGINWQRIDATYKKKTVVQPVPGLPMFTNGDATLDMDGDAWGWNVGFMLQPTDATRVGLSYRSRIKHTASGNTDVDNIALPGGRSASASYDAKASVDLPDSLILSVSHQLNDRWELLGDISWTGWSSIPELKIKNKNGPTDELPLKFRDSWRVALGANYQFAAQWKWKFGVAFDQSPVHDEADRPTSLPDTDRWWFSTGVQYAPTDNVTVDLGYTYLYLRDTDIDTTSGNPLTKGRVAGTYNSKGNIVGLQVSARF
>NZ_CP044089.1|WP_110128934.1|4542030_4542648_-|isochorismatase-family-protein
MSNDLGSYERQGFGAALPLKAPYGLLIVDFVNGFADPAQFGGGNIAAAIETTRMVLAAARERGWAVAHSRIVYADDDADGNIFSIKVPGMLTLKEHAPASAIVPQLAPQAGEYVVRKSTPSAFYGTMLAAWLAQRGVQTLLVAGATTSGCVRASVVDAMSAGFRPLVLSDCVGDRALGPHEANLFDMRQKYAAVMTHDEALAKTK
>NZ_CP044089.1|WP_033462175.1|4542663_4543695_-|2,5-dihydroxypyridine-5,6-dioxygenase
MPVSDYEMIRAWTQVLRLSRLQAGQTVTVLTSAATHPQTLGTALVAAQSLGAVVNRLDLPPVNGEKALSRDALAYLGTTPLTGNKAAIAMLKASDLVLDLMTLLFSPEQHEILQGGTRILLAVEPPEVLARLVPTEGDRQRVKAAAGRIAGAREMTVESEAGTRLRCGLGEFPAISEYGYVDEPGRWDHWPSGFALTWPDEGSANGTIVIDRGDILLPQKSYVSEPIVLTVENGYATRIEGGLDAEMLREYVATFKDPQAYAISHIGWGLQPRASWTTLGLYDREATIGMDARAYEGNFLFSLGPNNEAGGSRTTACHIDIPLRRCTVRLDGREVVREGKVLD
>NZ_CP044089.1|WP_150349125.1|4543722_4544544_-|alpha/beta-fold-hydrolase
MSNFRYGGNVQANGIRQHYLRYGGERAGRDPVIIVPGITSPAVTWGFVGERFGEQFDTYILDVRGRGLSQSGPQLDYGLDAQAEDLLAFARALGLSRYSVVGHSMGARIGIRAARTGEAGLARLAMVDPPVSGPGRRAYPSKLPWYVDSMAQARQGMTGEQMKAYCPSWTAEQLQLRAEWLHTCEERAVIASFEGFHEDDVHADLPRVRAARLLMTAERGEVVLDADVAEVEALAPGTVHVRVAGAGHMIPWDNEEGFYAAFGDFLGARLRAG
>NZ_CP044089.1|WP_010929891.1|4544562_4545315_-|maleate-isomerase
MQKTYRIGQIVPSSNTTMETEIPAMLLARQQIRGERFTFHSSRMRMKKVVKEELAAMDAESDRCAVELSDARVDVLGYACLVAIMAMGRGYHRQSQARLTAHTAANGGEAPVITSAGALVDALKVMGARKIAVVAPYMKPLTELVVDYIGNEGYEVVDYRALEIADNLEVGRHDAGRLPEIVAGLDYREADVIVLSACVQMPSLGAIAKVEAQTGKPVVTAAVATTYAMLKALGLEAVVPGAGALLSGAY
>NZ_CP044089.1|WP_014905577.1|4545615_4546767_+|6-hydroxynicotinate-3-monooxygenase
MQGKPRIAVIGAGLGGTAGAALMARAGFNVRLYEQAPAFSRLGAGIHLGPNVMKIMRRIGIEDELNRQGSHPDYWYSRDWQTGAELARIPLGDYAVSHYGATYLTVHRGDFHALMTAALPAGLLQFNKRLTRVDEDDDVVRLHFADGSVEEAEIVIGADGVNSRLREHLLGAELPKYTGYVAHRAVFPTPLDSGSLPFDMCVKWWSDDRHMMVYFVTGKRDEIYYVTGVPEQQWDMGKSWVPSSKEEMRAAFAGWHPTVQALIEATPEVSKWPLLERDPLPLWSRGRIVLLGDACHPMKPHMAQGAAMAIEDAAMLTRIFEQTGLQDHAAAFRLYEDNRAERASRVQRVSHDNTWLRTNENPDWCFGYDVYAEPLVEGRRAAA
>NZ_CP044089.1|WP_010928484.1|4546843_4547365_+|(2Fe-2S)-binding-protein
MPRRIEVCRIAMLAATRDFTLEVNASRHTVTADPDTPLLYILRNDLCLNGPKFGCGLGECGACAVLIDGVAARACTIPVRGAAGHAITTLEGLGTPQAPGPVQQAFIDEQAAQCGYCLNGMIIATQALLLRNAAPTDEDIRRELQYHLCRCGTHIEIMAAVRRAARLWAARQA
>NZ_CP044089.1|WP_080704947.1|4547361_4550211_+|c-type-cytochrome
MSRAGPPDAAPMAAMPAGSADLAPPAAGVLAGLVLRPPRASWNGERYTGPRAVHVDDSALQGLPGIVRVLVARDFVGIVATRPELAQQAAARLPVQWRAAPPGADAHPLWQHGPADAGAPMALEQRYRWPAADSHGMSTWALAWWREGALTVWTAAAAPALRRELAALLDLPPDAVRVLAYGVPPGQAADLAALDTAADAALLSRAVGQPVRVAGSPMAWPAPASGAIRLGADFDAQGGIAALRIRHDGAGLARPSLARLLAGGAGAAPADAPPYRFGAVRLAADSQGTLPPGAARLPGQRAAQVFALESFLDEAAIRAGVDPVEYRLRHLDDARGAALIRQVAQQAGWQASGRGGRGGRGFAYASVIDDSVDPPLRSWSAWVADVSVDPDSGGVALTRVVVGHDLEATAAPGQDAPRIEQHLRDTAGRLLGPPAAYDDWSVPAAPIAGQLPTPEVVRPASALATPTALAWSDTASLPAAAAVANAIFDATGIRLREPPFNGAQARRALSAAAPARRGNRGAYAWLGGIAAAATGLVVAAWPWRPAIAPVAGPEPGLYSAAAIERGRLVAAAGDCVVCHTAPGGAPNAGGLALDTPFGAIYTTNITPDVATGIGQWSYAAFERAMRQGIHRDGRQLYPAFPYTSFAKLSEADMQALYAYLMAQPPVAATPPPTRLPFPYNLRPLMAGWNALFHDARPYQPDPERSTLWNRGAYLVQGAGHCGACHTPRNSLGAERGGERHFLGGGVAEGWDAPALNALSRAPVPWTEQDLYAYLRTGFSARHGVAAGPMAPVVQSMAQLPDADVRAMAHYLSSLSPAADSAGVEAAVQALERASEPGARLLPPNGERLFQGACAVCHETRHTAPQFGVRPSLALNTNLHSARPDNLIQVILHGIVEPANGQLGYMPAFGDSLDAGQIAELVQYMRARFAPGEPAWQDVAQRVRELSRQE
>NZ_CP044089.1|WP_003820163.1|4550302_4551076_-|ABC-transporter-ATP-binding-protein
MSTVAEPTRAAAAATQAPALLRVAGLNAWYGAAHILFDVDLEVRRGEVVALMGRNGAGKSTTFKAVMGLLAKRRGAVEFMGRDIAGLQPFEIARLGLGFVPEDRRVFTDLTVTENLEVGRQPARRWPDGSAAPNWQPGALYELFPNLGAMQDRPGGQMSGGEQQMLTVARTLMGNPFLVLLDEPSEGVAPVIVEQMAGMILALKAQGASILLSEQNVHFAELVSDRVYVLEKGQIRYSGSMAELADNEEVRRAYLTV
>NZ_CP044089.1|WP_003820162.1|4551072_4551849_-|ABC-transporter-ATP-binding-protein
MSLLQVRNLSKAFGGVRAVDDISFDLAAGELLALIGPNGAGKSTTFNMVGGQLPATTGSVRLDGHELVGMRPRDIWRLGVGRTFQIAATFASLTVVENVQMALLSHHRRIFSFGSLAARQYREPALALLEQVGMRDQAERPCSELAYGDVKRVELAMGLANDPKLLLMDEPTAGMAPQERNALMALTKRLVVDRGMAVLFTEHSMDVVFAYADRMIVLARGRLIAEGGAQEIRNHPKVQEVYFGTGKTFEKHSAGAAA
>NZ_CP044089.1|WP_003820161.1|4551845_4553795_-|ABC-transporter-permease
MDLTGFLAQLLNGLAEASSLFLVAAGLSLIFGVTRIVNFAHGSLYMLGVYVAYSIVERVGGTALGFWFGLVAASLAVGVVGAAIEVVLLRRIYRAPELFQLLATFALVLVINDAALWIWGAEDLLGRRAPGLTGAVDLLGRQYPVYNLVLIVIGPVVLGLLWLLLTRTRWGTLVRAATQDREMLGALGVNQAWLFTGVFALGAMLAGLGGALQLPREPASLSLDLRTIGDAFVIVVVGGMGSIPGAYVAALIIAEIKALCIGLGTVTLLGFSVSFSKLTLVVEFAFMALVLVFRPWGLFGRPQGASRNSAPIEAPLRPAAPRLRILWGVLLAALAVLPLLAQWLPYAVVLTQDILIAALFAVSLHFMMGPGGMHSFGHAAYFGLGAYGAALLLKAASLPMEAALAFAPLVAALGALVFGWFCVRLSGVYLAMLTLAFSQIVWSVVFQWDDFTGGSNGMIGVWPAEWLSGTAYYYLALAVVAAAVLGLRRVLFSPFGYAMRAGRDSSLRADAIGIDVKRVQWAAFVVAGAFGGLAGALYAFSKGSISPDTMAVSKSVDGLVMVLLGGIQTLIGPVVGATAFNVLQDYIMRATEYWRALFGGVILLLVLVFPQGIAGFCRQAGQWWSARAGKDRPPRKGGAFIGGPREKQA

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Crispr_ID: NZ_CP044089_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_11

4585917-4586016

Orphan

Consensus_repeat	Method
GTGGCTCGGTTGCAGGTGCCTGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_11

>merge|NZ_CP044089|11|4585917-4586016|CRISPRCasFinder
GTGGCTCGGTTGCAGGTGCCTGTCCCGGCGGGGACAGGCACCGGGCGGGGCTGTGCCGATGGGATGTCGGGTGACGTGGCTCGGTCGCAGGTGCCTGTCC

>NZ_CP044089|11|10|4585917-4586016|CRISPRCasFinder
GTGGCTCGGTTGCAGGTGCCTGTCC	CGGCGGGGACAGGCACCGGGCGGGGCTGTGCCGATGGGATGTCGGGTGAC
GTGGCTCGGTCGCAGGTGCCTGTCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003820134.1\|4578772_4579540_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235712
NZ_CP044089.1\|WP_003820117.1\|4592086_4592770_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP044089.1\|WP_003810020.1\|4583443_4583968_-\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|377284
NZ_CP044089.1\|WP_003820128.1\|4582172_4583441_-\|TRAP-transporter-large-permease	unknown	unknown	gnl\|CDD\|224509
NZ_CP044089.1\|WP_003820116.1\|4593400_4594177_+\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|235420
NZ_CP044089.1\|WP_004568037.1\|4581160_4582144_-\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270321
NZ_CP044089.1\|WP_042997565.1\|4583964_4584906_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|235706
NZ_CP044089.1\|WP_003820136.1\|4578046_4578685_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP044089.1\|WP_003810012.1\|4586263_4587556_-\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
NZ_CP044089.1\|WP_003820133.1\|4579554_4580358_-\|aspartate-dehydrogenase	unknown	unknown	gnl\|CDD\|106261
NZ_CP044089.1\|WP_003820122.1\|4585271_4585772_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380396
NZ_CP044089.1\|WP_125327728.1\|4590389_4591847_-\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
NZ_CP044089.1\|WP_003809999.1\|4592898_4593408_+\|cyclophilin	unknown	unknown	gnl\|CDD\|182734
NZ_CP044089.1\|WP_033471138.1\|4587628_4588663_-\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
NZ_CP044089.1\|WP_003820119.1\|4589725_4590370_-\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP044089.1\|WP_003809992.1\|4595272_4596859_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|223930
NZ_CP044089.1\|WP_050450662.1\|4580354_4581164_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|211851
NZ_CP044089.1\|WP_003809994.1\|4594384_4595248_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NZ_CP044089.1\|WP_003810007.1\|4588723_4589689_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
NZ_CP044089.1\|WP_003810016.1\|4584915_4585230_-\|NIPSNAP-family-protein	unknown	unknown	gnl\|CDD\|311781

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_003820134.1\|4578772_4579540_-\|SDR-family-oxidoreductase	gnl\|CDD\|235712	PRK06138, PRK06138, SDR family oxidoreductase.	4.5213e-117
NZ_CP044089.1\|WP_003820117.1\|4592086_4592770_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.46032e-10
NZ_CP044089.1\|WP_003810020.1\|4583443_4583968_-\|TRAP-transporter-small-permease	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	2.28017e-25
NZ_CP044089.1\|WP_003820128.1\|4582172_4583441_-\|TRAP-transporter-large-permease	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	1.5449e-125
NZ_CP044089.1\|WP_003820116.1\|4593400_4594177_+\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|235420	PRK05340, PRK05340, UDP-2,3-diacylglucosamine hydrolase; Provisional.	2.04318e-114
NZ_CP044089.1\|WP_004568037.1\|4581160_4582144_-\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270321	cd13603, PBP2_TRAP_Siap_TeaA_like, Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP) and related proteins; the type 2 periplasmic-binding protein fold. This subfamily includes the periplasmic-binding component of TRAP transport systems such as SiaP (a sialic acid binding virulence factor), TeaA (an ectoine binding protein), and an uncharacterized TM0322 from hyperthermophilic bacterium Thermotoga maritima. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.15079e-96
NZ_CP044089.1\|WP_042997565.1\|4583964_4584906_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|235706	PRK06129, PRK06129, 3-hydroxyacyl-CoA dehydrogenase; Validated.	2.20156e-145
NZ_CP044089.1\|WP_003820136.1\|4578046_4578685_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.42874e-07
NZ_CP044089.1\|WP_003810012.1\|4586263_4587556_-\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
NZ_CP044089.1\|WP_003820133.1\|4579554_4580358_-\|aspartate-dehydrogenase	gnl\|CDD\|106261	PRK13301, PRK13301, putative L-aspartate dehydrogenase; Provisional.	2.99901e-157
NZ_CP044089.1\|WP_003820122.1\|4585271_4585772_-\|cupin-domain-containing-protein	gnl\|CDD\|380396	cd06991, cupin_TcmJ-like, TcmJ monooxygenase and related proteins, cupin domain. This family includes TcmJ, a subunit of the tetracenomycin (TCM) polyketide synthase (PKS) type II complex in Streptomyces glaucescens. TcmJ is a quinone-forming monooxygenase involved in the modification of aromatic polyketides synthesized by polyketide synthases of types II and III. Orthologs of TcmJ include the Streptomyces BenD (benastatin biosynthetic pathway), the Streptomyces olivaceus ElmJ (polyketide antibiotic elloramycin biosynthetic pathway), the Actinomadura hibisca PdmL (pradimicin biosynthetic pathway), the Streptomyces cyaneus CurC (curamycin biosynthetic pathway), the Streptomyces rishiriensis Lct30 (lactonamycin biosynthetic pathway), and the Streptomyces WhiE II (spore pigment polyketide biosynthetic pathway). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.05427e-15
NZ_CP044089.1\|WP_125327728.1\|4590389_4591847_-\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
NZ_CP044089.1\|WP_003809999.1\|4592898_4593408_+\|cyclophilin	gnl\|CDD\|182734	PRK10791, PRK10791, peptidylprolyl isomerase B.	5.87344e-90
NZ_CP044089.1\|WP_033471138.1\|4587628_4588663_-\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	4.38203e-63
NZ_CP044089.1\|WP_003820119.1\|4589725_4590370_-\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	4.52687e-55
NZ_CP044089.1\|WP_003809992.1\|4595272_4596859_-\|TerC-family-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	4.32604e-97
NZ_CP044089.1\|WP_050450662.1\|4580354_4581164_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|211851	TIGR03611, RutD, pyrimidine utilization protein D. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the hydrolase, alpha/beta fold family defined by pfam00067.	8.34617e-38
NZ_CP044089.1\|WP_003809994.1\|4594384_4595248_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	8.52893e-109
NZ_CP044089.1\|WP_003810007.1\|4588723_4589689_-\|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
NZ_CP044089.1\|WP_003810016.1\|4584915_4585230_-\|NIPSNAP-family-protein	gnl\|CDD\|311781	pfam07978, NIPSNAP, NIPSNAP. Members of this family include many hypothetical proteins. It also includes members of the NIPSNAP family which have putative roles in vesicular transport. This domain is often found in duplicate.	7.86859e-37

>NZ_CP044089.1|WP_003820122.1|4585271_4585772_-|cupin-domain-containing-protein
MKQQHEPGIAVVVGPDEGDSFWQPVPANGFVRTLLNRANTGASVDFSAGTQTVAPGCHVREHFHDDREEVIFITEGTGTALIDGVEHPLAPGACLFLGKSRKHSFLNAGPEPLSFFWILMPGGLDDFFRQIGRVRQPGEPAPQPFARPADIDRIEANTVFGWTAKS
>NZ_CP044089.1|WP_003810016.1|4584915_4585230_-|NIPSNAP-family-protein
MFIEERDYRIKPGKAGLFVATYEAHGLALQKKYLGRFLGYFMSEIGELNHVVAWWAYDSLDERDAARSRMLADPQWQAYLERVTDLIDLQQTRILKPVSFSPIQ
>NZ_CP044089.1|WP_042997565.1|4583964_4584906_-|3-hydroxyacyl-CoA-dehydrogenase
MNHVAVIGGGIIGASWAVVFARRGLEVTIVERDAACLVGLPARLAGMIERSASLLRAGEQPGDVAARIGATDALAAAVGRADYVQEAVSENLALKRTLFAELDALAPAHALLASSTSTYGASQFTEALAGRARCLVAHPMTPPHLSPVVEMAASAWTDPQALAGAETFMRSLGQHPVRIRKEIPGFVLNRLQGALLMEMFRVIADDVISPADADALISQGLGLRWATLGPLEGVDLNAPGGIADYLQRYGHIFNDMAAGQGLPAPVDAELISALDGAMRAALPLERLEAKRGWRDRAIAGVRVALHDYTGEKP
>NZ_CP044089.1|WP_003810020.1|4583443_4583968_-|TRAP-transporter-small-permease
MKLIRAVDGLNRLACWLMAGLMLGMTLCTLWQVSVRFLLTGLGWNVAAPWSEEVSRYLMIWIIFLGAGVACRKAQLIALELVVTLLPAPLGRALRFAALLGCLVFFTLMIYLGLEFMEFGAIETSPVLSMPKTWIYLAMPVGFGLMFLNTATLIAECLLQGIDIRHASQQEAQE
>NZ_CP044089.1|WP_003820128.1|4582172_4583441_-|TRAP-transporter-large-permease
MLSAVVLLLLLFAASIPVALSLGIAPLPALLARDVPLLAVPQTMFESMDSFALMAVPFFVLAGRLMQTGGIAGRLMDLGLALIGWVKGGLGGAAVLTTMFFSTICGSSSATTAAIGSVMIPEMERRGYPRPFAASVVASSGELGVILPPSVPMIIYAMLTGTSVAQMFVAGILPGLLIGLSLIITILIMSRLGDYGGSQRVSVGEWALNVWRALRRASLSLLMPVIILGGIYGGLFTATEAAVVAVAYTFVVSVFIYREIKWKDLPEIFWSSAVTSGIVLLIVGFASVFAYVLSLYQAPQQVAALLLGVSDNPLVFLLLVNIALLVVGLFMETFAAILILAPVLAPVAVSLGIDPVHFGLIVIVNLAVGMVTPPVGVNLFLVCGIARVSMERLMRPLSVFLGVLLLDLIIITYGPVLYARFF
>NZ_CP044089.1|WP_004568037.1|4581160_4582144_-|TRAP-transporter-substrate-binding-protein
MNVVKSLFAALALAGASFGASAEPIQINIGHALGDTSSYQVAGLHFAELMKQKVGDKVKVTLYPSGGLGGELKLVQGARTGVVDAMIIAQASLENTVREYRVLSLPYLFTDYEEANRIMQGPVGDRLLDVLPKYNMVGLGWGAVYARSLASMKPVPDLAAMKGLKVRVIQSPGFVEAYRALGSQPTPTAYAELFLSLQNGVVDAAELSPDQTVADGFAEVIKYYSVTAAHQLPSLFIISKAKFDRLPEDVRKAVEEAGRESMQVAVKFQDQKLAEAFDVLKQRGVQVQYPDQAPLREAARGAWDQIAKAAPGGEQFLVEIEAARAAK
>NZ_CP044089.1|WP_050450662.1|4580354_4581164_-|alpha/beta-fold-hydrolase
MIRQRMTDFTVILPDGARLAARETGAGEAVLLVSGLGGTGAFWTPVAAGLQGRRCVMFDQRGVAGSTRGDAAVDIARLAADAWAVLDARGIERAHLVGHSTGGCIVQEMALSAPARAASLVLGGTWGGRNAYMQSLFAMRAALLAASPALYEQAGAYLSYPAAWLLAHPEAVPAAAAPWPAQRVAVVRERIAALLAYDRLDDLPGLDAPALVLGARDDQIVPFALQQQLARVLPGAQLRPLEHGGHFFPIVRGADYVAALLDWFGHHSL
>NZ_CP044089.1|WP_003820133.1|4579554_4580358_-|aspartate-dehydrogenase
MTHRIAFIGLGAIASDVAAGLLADAAQPCQLAALTRNAADLPPALAGRVALLDGLPGLLAWRPDLVVEAAGQQAIAEHAEGCLTAGLDMIICSAGALADDALRARLIAAAEAGGARIRVPAGAIAGLDYLQAVAGRDDAEVVYESRKPVAAWRAELPGMGIDPDTLAESRTLFSGPAREAALRFPKNLNVAATLALAGIGMTRTRVEVVVDPQARGNQHRIQVRSPLGEMQIELVNAPSPANPKTSWLVAQSVLATIRRHLARFTIG
>NZ_CP044089.1|WP_003820134.1|4578772_4579540_-|SDR-family-oxidoreductase
MTQRLSGRIAIVTGAGSGIGEATARLMAREGAVVVVADKAIEAAERVAQAIVAEGGRAEARQADVGEAQSVRALVDAVAARWERIDVLVNNAGYGIAATVVDTDEADWSALMRVNVDGVFLGCKYVIPIMQRQGAGVIVNTASAGALVGLRQRAAYCASKGAVAALTRAMALDHATEGIRINCVAPGTIESPYFREIYARSDDPEALRASLAARQPMNRLGQPEEVARAIVFLASDDASFATGSTLVLDGGLTAA
>NZ_CP044089.1|WP_003820136.1|4578046_4578685_-|TetR/AcrR-family-transcriptional-regulator
MKATPAQVPMKERIKEVATDMLIAHGSSGFRFQQIAQALDCTRGNIHYHYRHKHELVEDVTIEYCQRTIGHFDQIWLSDSTLSQKIQLSMQFNEMRYLKRNPQGDTSHPWSLIARMRLESALITPAAREALARYSHELQRSVVAGVRRAVEKGELRPDTPVEMVALPIIEMANSADPITRDAGRFDRLRQMYQAVDRLIHDAYGMAGHRPAP
>NZ_CP044089.1|WP_003810012.1|4586263_4587556_-|aspartate-kinase
MRACQPEYEMSLIVQKYGGTSMGSVERIKNVARRVAKWHAAGHKVVVVPSAMAGETNRLLSLAREISPQPDGRELDMIAATGEQASSGMLAIALQAEGVPARSYAGWQVPVRTDSSYTKARIKSIDDKRVLADLDAGRVVIVTGFQGVDDDGHITTLGRGGSDTSAVAVAAAIKADECLIFTDVDGVYTTDPRVVPEARRMAVVSFEEMLEMASLGSKVLQIRSVEFAGKYHVPTRVLSSLTDPLIPLEEEMRSGTLITFEEDEKMEAAVVSGIAFSRDEAKITLLAVPDKPGIAYSILGPVAAANIDVDMIVQNQSVAGTTDFSFTVNRNEYQRTLDLLKREVIPAVSARELVTDEKVAKVSIVGIGMRSHVGVASLMFQTLSQEGINIQMISTSEIKTSVIIDDKYMELAVRSLHKAFGLDQVPGDQV
>NZ_CP044089.1|WP_033471138.1|4587628_4588663_-|tRNA-lysidine(34)-synthetase-TilS
MSTSPAAPAPSLSDLCPAALRRPVADALRALDPAPARLAVAVSGGADSAMLAVAAAAALPPGCTLRLFHVHHGLQAAADQWAAQVRGLGALLGVPVDEARVTVPPGQGLGMEAAARLARYQALAGLARQHGVRHILLAHHRNDQAETVLLRLLRGTGLQGMAAMAPFSERDGVAYLRPWLDVDRAAILALAGAVRAQCGWQAVQDPTNTDPRYARAAVRTQLAPALDARWPGWQAIVARHARQMAEAAEIVAEVARADFATLEPADAGRSFSLAAWRGLSAARQAQALRHWLASQDAPMPTEARLAELQRQLRQLHALGHDRHLRWQHAGRVVRCERGRVWIDD
>NZ_CP044089.1|WP_003810007.1|4588723_4589689_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MRNTFLEFEQPLAELENKIEQLRYVQADSAVDISDEIGRLQQKSQNLAKEIYGKLTPWQTALVARHPQRPYTLDYVREIFTDFHELHGDRMYADDQSIVGGLARFNGSACMVIGHQKGRDTKERAARNFGMPRPEGYRKALRLMRLAEKFRLPIFTFIDTPGAYPGIGAEERGQSEAIGRNLYAMAELKVPVICTVIGEGGSGGALAIAVGNAVLMLQYATYSVISPEGCASILWRSADKAPEAAEALAITAPRLKDLGLVDRVVNEPVGGAHRDPRVMARLLRRALGDALRQLQGLGPEQLVDQRLQRLMSYGRFQEVRA
>NZ_CP044089.1|WP_003820119.1|4589725_4590370_-|DNA-3-methyladenine-glycosylase-2-family-protein
MSSADIVIVKPEYWDDAVAHLMRRDRILKRIIPQHGETWLTSRGSPFVTLARAIIGQQISVKAADALWQRFLETVGKRPTPATVLRAGVPALRAAGLSQRKAEYLVDLATHFGQRLVHPEKWAAMDDEAVIAELVAIRGIGRWTAEMFLIFNLQRPDVLPLDDLGLLKAISLHYFSGEPVSRFEAREVSLAWQPWRTVATWYLWRSLEPAAVQY
>NZ_CP044089.1|WP_125327728.1|4590389_4591847_-|cysteine--tRNA-ligase
MLHIYNTLSRTKEPFKPAHAGQVRMYVCGMTVYDYCHLGHARMLVAFDVVQRWLRASGLAVDYVRNITDIDDKIIRRAVETGRRIGEVTEYYIAAMHADERALGVQRPDREPRATQYVGEMLDIIGRLESKGLAYRAEDGDVNYAVRGFADYGKLSGKSLDDLRAGERVAVGSAKRDPLDFVLWKSAKPQEPDDTKWESPYGLGRPGWHIECSAMSKTLLGLPLDIHGGGPDLKFPHHENEIAQTEGAFGGALANVWMHCGPLMVDADKMSKSLGNFRTIRQTIAQGPLSDTQAEYAVNPREAEMLRFFIVRNHYRSPQNYAPDNLVDAQNALDRLYQALQNTAADGQGVDWSEPQAQAFKAAMDDDFNSSGAVAALFELASEANRTGSARAAGQLKALGAVLGLLQQDPPAYFQSPTRYSAAARGQGAPAAALDAAAIEARIAERAAAKAARDFARADAIRAELRAAGIELDDKPGGLTQWRRA
>NZ_CP044089.1|WP_003820117.1|4592086_4592770_+|tetratricopeptide-repeat-protein
MTTKPRLCTALLTLAIAVSASAPVLAQSMAGGSAKNRYANQTKLDPYPPEGGWQGLANLLEAAKPGVDTRLDPTPSQITDRIEELLNRGANEEALSLIERREAAIKGQRGADVQLMFQHARALAALGRADEAIAVYSDMTNQFPELPEPWNNLAALYASRGELERAQDSLQMALRANPDYAAARANLGDIQLMMALRTYRQEAARGVPGMKARVEEIESLLKDKQPK
>NZ_CP044089.1|WP_003809999.1|4592898_4593408_+|cyclophilin
MSTNPRVKLHTNQGDIIITLNAEKAPKSVENFVAYTKDGFYDGTVFHRVIDGFMIQGGGFEPGMKQKPTKAPIENEANNGLKNDKYTLAMARTSDPHSATAQFFINVSDNDFLNFTAPTPNGWGYAVFGVVTEGTEVVDKIKNVKTGNRGFHQNVPAEDVIIEKAEVLE
>NZ_CP044089.1|WP_003820116.1|4593400_4594177_+|UDP-2,3-diacylglucosamine-diphosphatase
MNKLALQGPLWLASDLHLGPATPATAEAFLGLLQAAADEASALLLPGDIFDAWIGDDVIRAAPPWLAAVLQGIRAAAGRIPVYLGRGNRDFLIGQELADALGAHLLPEPVLLETDYGRILLTHGDEYCTDDSAYQQFRAMVRNPQWQAQFLAKSIPERLAMAEQARGESQAANQAKSMEIMDVNPAAVEAALREADVDVLVHGHTHRPARHVLSVDGRKRERWVLPDWDCDHADPPRGGWLVIDRDGLQCFDLVEDED
>NZ_CP044089.1|WP_003809994.1|4594384_4595248_-|undecaprenyl-diphosphate-phosphatase
MTDSTLHLLKAFFLGIVEGLTEFIPVSSTGHLIVIGDWINFASSSGKVFEVVIQFGSILAVMWIFRARLWQLIRGTLTGVRQEVNFTRNLLLAFLPAAVIGAIFIKSIKQVFYHPGVVAVTLVVGGFIMLWVERRAPHTPGDAPGAADDTASDERATAHTLEQISAKQALGVGVAQCVAMIPGVSRSGATIIGGMIAGIQRKTATEFSFFLAMPTMLGAAVYDLYRNIGLLSQHDMSAIAVGFVAAFLSALVVVRAVLRFVANHTYRVFAWYRIALGLVVAAWIYAK
>NZ_CP044089.1|WP_003809992.1|4595272_4596859_-|TerC-family-protein
MEWLQDPAAWVGLLTLVVLEIVLGIDNLIFIAILADKLPPAQRDRARIVGLSLALLMRLGLLSVMSWLVTLTTPWFSVGPMSFSGRDLILMLGGLFLLFKGTMELHERIEGGQSLDTGGPRVYASFWVIVTQIVVLDAVFSLDSVITAVGMVDHLAIMMIAVIIAIGIMLLASKPLTRFVNAHPTVVVLCLGFLLMIGFSLLAESFGFKVPKGYLYAAIGFSVAIEALNQVARRNLLKLDARRPMRERTATAVLRMLGKRPPASDESDLPSAMPAVPAFGVEERNMVSGVLTLAERSIRSIMTPRTDVSWVNIDDDAATIRQQLTAAPHSFFPVCRGSLDEVVGIGRAKDLVADLITEGRVRRNRLRDPIIVHESIGILRLMDTLKRSRGQLVLVADEFGAIEGLVTPIDVFEAIAGEFPDEDELPDIVAESENVWKVDGAADLHHLEQVLEIEGLIDESEDYSTLAGYLLARFGHLPKPGDTCEFEGSHHRRVRFEVLQMDGRRVALVRVERLPYDTVDESEAADAD

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Crispr_ID: NZ_CP044089_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_12

4928325-4928452

Orphan

Consensus_repeat	Method
TGGGGAGCGAAGGGTGCCTGTCCCCGCCGGGACAGGCACTTCCGTCCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_12

>merge|NZ_CP044089|12|4928325-4928452|CRISPRCasFinder
TGGGGAGCGAAGGGTGCCTGTCCCCGCCGGGACAGGCACTTCCGTCCTGGCCCGATGCGCGAGGTGCCTGTCCCCGCTTGGGGAGCGACAGGGTGCCTGTCCCCGCCGGGACAGGCACTTCCGTCCTG

>NZ_CP044089|12|11|4928325-4928452|CRISPRCasFinder
TGGGGAGCGAAGGGTGCCTGTCCCCGCCGGGACAGGCACTTCCGTCCTG	GCCCGATGCGCGAGGTGCCTGTCCCCGCTT
GGGGAGCGACAGGGTGCCTGTCCCCGCCGGGACAGGCACTTCCGTCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_033467977.1\|4916932_4919680_-\|pertactin-autotransporter	unknown	unknown	gnl\|CDD\|273608
NZ_CP044089.1\|WP_003819779.1\|4929394_4930822_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
NZ_CP044089.1\|WP_003809411.1\|4927292_4928228_+\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
NZ_CP044089.1\|WP_003809431.1\|4914463_4915180_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_003809414.1\|4925362_4927243_+\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
NZ_CP044089.1\|WP_003819789.1\|4920273_4920915_-\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP044089.1\|WP_033453727.1\|4915444_4916866_+\|uroporphyrinogen-III-C-methyltransferase	unknown	unknown	gnl\|CDD\|182606
NZ_CP044089.1\|WP_004568239.1\|4932429_4933332_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|226910
NZ_CP044089.1\|WP_033467975.1\|4922599_4923673_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
NZ_CP044089.1\|WP_003809396.1\|4931830_4932304_+\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP044089.1\|WP_003809416.1\|4924951_4925296_+\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235518
NZ_CP044089.1\|WP_003809388.1\|4936998_4937697_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP044089.1\|WP_004568238.1\|4923669_4924806_+\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
NZ_CP044089.1\|WP_015041210.1\|4933328_4934972_+\|apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
NZ_CP044089.1\|WP_003819788.1\|4921005_4922442_-\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|224938
NZ_CP044089.1\|WP_003809398.1\|4930818_4931841_+\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
NZ_CP044089.1\|WP_080704265.1\|4939108_4940101_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
NZ_CP044089.1\|WP_003819773.1\|4934968_4935976_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381328
NZ_CP044089.1\|WP_003819780.1\|4928509_4929238_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239483
NZ_CP044089.1\|WP_003819771.1\|4937693_4939079_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377179

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_033467977.1\|4916932_4919680_-\|pertactin-autotransporter	gnl\|CDD\|273608	TIGR01414, Contains:_AIDA-I_translocator, outer membrane autotransporter barrel domain. A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	1.57336e-113
NZ_CP044089.1\|WP_003819779.1\|4929394_4930822_+\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
NZ_CP044089.1\|WP_003809411.1\|4927292_4928228_+\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	7.49349e-144
NZ_CP044089.1\|WP_003809396.1\|4931830_4932304_+\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	3.20839e-53
NZ_CP044089.1\|WP_003809414.1\|4925362_4927243_+\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	0
NZ_CP044089.1\|WP_003819789.1\|4920273_4920915_-\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	6.55206e-126
NZ_CP044089.1\|WP_033453727.1\|4915444_4916866_+\|uroporphyrinogen-III-C-methyltransferase	gnl\|CDD\|182606	PRK10637, cysG, siroheme synthase CysG.	6.32102e-175
NZ_CP044089.1\|WP_004568239.1\|4932429_4933332_+\|CBS-domain-containing-protein	gnl\|CDD\|226910	COG4535, CorC, Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism].	2.5665e-108
NZ_CP044089.1\|WP_033467975.1\|4922599_4923673_+\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
NZ_CP044089.1\|WP_003809416.1\|4924951_4925296_+\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235518	PRK05585, yajC, preprotein translocase subunit YajC; Validated.	5.53938e-43
NZ_CP044089.1\|WP_003809388.1\|4936998_4937697_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.67018e-41
NZ_CP044089.1\|WP_004568238.1\|4923669_4924806_+\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
NZ_CP044089.1\|WP_015041210.1\|4933328_4934972_+\|apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	4.94075e-170
NZ_CP044089.1\|WP_003819788.1\|4921005_4922442_-\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|224938	COG2027, DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane].	2.7893e-89
NZ_CP044089.1\|WP_003809398.1\|4930818_4931841_+\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	4.19811e-141
NZ_CP044089.1\|WP_080704265.1\|4939108_4940101_-\|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	2.52056e-148
NZ_CP044089.1\|WP_003819773.1\|4934968_4935976_-\|aldo/keto-reductase	gnl\|CDD\|381328	cd19102, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.21899e-142
NZ_CP044089.1\|WP_003819780.1\|4928509_4929238_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239483	cd03389, PAP2_lipid_A_1_phosphatase, PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.	6.13555e-75
NZ_CP044089.1\|WP_003819771.1\|4937693_4939079_+\|hypothetical-protein	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	1.16369e-63

>NZ_CP044089.1|WP_003809411.1|4927292_4928228_+|protein-translocase-subunit-SecF
MEFFRIHRTIPFMRHALVLNIISLVTFLAAVFFIITRGFHLSIEFTGGTVMEVSYAQTAQLDQVRTAIGTLGYTDFQVQNFGTSRDVMIRLPIAEGQTSATQSETVMGALKAADPAVELRRVEFVGPQIGQELLHNGLMALLVVVIGIMVYLGLRFEWKFAVAGVIANLHDVVIILGFFAFFQWEFSLAVLAGVLAVLGYSVNESVVIMDRIRENFRKYRKASVQEVINSAITQTISRTIITHGSTQMMVLAMLFFGGPTLHYFSLALTIGIWFGIYSSVFVAAALAMWMGVKREDLVKPVKKDGDEVEIA
>NZ_CP044089.1|WP_003809414.1|4925362_4927243_+|protein-translocase-subunit-SecD
MNRYPLWKYITVLVAVVIGLLYTLPNFYGESPAVQVSSAKATIKVDQATLEQVQQIIENAQLPADSVYYEQNGTLGTVRARFPSTDVQLQARDLIDRTLNTVAGDPHYTVALNLLPASPPWMRSLGWFEPKPMYLGLDLRGGVHFLLQVDMQGALTARYDSLVADVRSALRDQKAEVGAIERSGQSVVATFATAEQRDRARDVLRSRLPDLQFTETSDGGKLQLTGMLNPAAVTRVQDTALKQNINTLHNRINELGVAEPVIQQQGADRIIVQLPGVQDVAKAKELLGRTATLEIRMVDDSPAAQSALAAGSVPFGLERYTDRDGRPLLVRRQVVLTGENLQDAQPGRDGQTQQPAVHLTLDSKGARIFRDVTRDNIGKRMAILLFENGKGEVVTAPVIRSEIGGGQVQISGSMTAEEAADTALLLRAGALAAPMSIIEERTIGPSLGADNIAKGFYSTLYGFIAIAIFIIVYYHLFGIFSTIGLTVNVLLLLALLSMLQATLTLPGIAAIALTLGMAIDANVLINERIREELRNGATPQQAIHHGFERAWGTILDSNLTTLIVGLALLAFGSGPIRGFAVVHCLGIVTSMFSSVVGVRALANLWYGRKKKLSSISIGTVWKPKAN
>NZ_CP044089.1|WP_003809416.1|4924951_4925296_+|preprotein-translocase-subunit-YajC
MSAIDTAGLVLAQAAPAEGNALMGMLPIVLMFVILYFLMIRPQMKRQKEHRNMVAALSKGDEVVTSGGMLGRVSKVTDSYITVEVSELADKPVEVVMQKTAVSAVLPKGTIKAL
>NZ_CP044089.1|WP_004568238.1|4923669_4924806_+|tRNA-guanosine(34)-transglycosylase-Tgt
MTGLQFELLATDGGARRGRLTLNHGVVETPIFMPVGTYGSVKAMLPHELEDIGAQIVLGNTFHLWLRPGTAIMEKHGGLHGFMQWDKPILTDSGGFQVFSLQGMRKITEEGVKFASPIDGARLFLTPEESMRIQRSLNSDIVMVFDECTPYEIDGRPASIDEAARSMRMSLRWARRSRDEFDRLGNPNALFGIVQGGMYETLRDESLAGLAEIGFHGYAIGGLSVGEPKEDMMRILAHVTPRLPAQAPRYLMGVGTPEDLVEGVARGVDMFDCVMPTRNARNGWLFTRYGDVKIRNARYRDDTRPLDPSCACHTCTHFSRAYLHHLQRANEITGARLNTLHNLHFYLAIMGEMREAIAAGRFEAWRAQFAADRARGVD
>NZ_CP044089.1|WP_033467975.1|4922599_4923673_+|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MAAAFHRTYRVPTPLTLADFDYHLPPELIAQSPAAERGGSRLLHLDAASRLHDRRFPDLAGLLRPHDLLVFNDTRVIKARLTGQKATGGKVEVLVERITAPDRALAHVRASKSPGPGMRLRLAEAFEAEVLGREGELFDLRFPAPVLDLLDAHGATPLPPYITHAADATDERRYQTVYAREPGAVAAPTAGLHFDQPMLEQLAAQGVQRAFVTLHVGAGTFQPVRAQNLAEHIMHAEWYTVPEATVAAIARARAHGGRIVAVGTTSVRALESAAAQAQDGPLAAAQGDTRLFITPGYRYRVVDALLTNFHLPQSTLLMLVSALAGVEPIRRAYAHAVAERYRFFSYGDAMFIETPAP
>NZ_CP044089.1|WP_003819788.1|4921005_4922442_-|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MRRAGKQGKWQQWLAGVMLALGAAGAAAQGLPSSLVAAWKATKLPDQSLSLVVQEINGPRLATLNAKEPRNPASVMKLVTTWAALSELGPSYAWRTEFLTEPGNRPDAHGVLRGPLYLRAGGDPQLLLQDLWALLRELRLRGVKQIGDLVVDRSIFGQVAIDPGAFDGASDRAYNASPDALMVGFGAQRLLFTPDAAARKWVPMIDPPLPGLRLEGAVEWSDVRCPGPPVVGTEPVVTQQGVSIRLSGKVAGSCGEFSLYRLALSQPEYASAVFRLLWRELGGTLKGQIRSGVVPPDAVVLASHDSPTLGEAIRTINKRSNNVMARTLLLTLGAERGRRPATVESSGVVARAVLGAQGLEMPELVIDNGSGLSREGRVSADSLASMLTVAWNSPLMPEFISSLAIAGVDGTVRRRLKGNGAQGMAHLKTGSLRDVRAVAGYVLGASGKRYVVVSMVNHENAAAVRSFDDALVAWLAEQ
>NZ_CP044089.1|WP_003819789.1|4920273_4920915_-|uracil-phosphoribosyltransferase
MPVHEIRHPLIRHKLGIMRRADLSTKSFRELSQEVAALLTYEATKDMPLAPASVEGWCGTVEVDKIAGKKVTVVPILRAGIGMLDGVLSLIPGAKVSVVGVARNEETLQAHTYLERLVGELDQRLALIVDPMLATGGSMVAAIDMLKRAGCREIRALTLVSAPEGIDAVLKAHPDVQIYTASIDQGLNENGYIMPGLGDAGDRIFGTTQKHAE
>NZ_CP044089.1|WP_033467977.1|4916932_4919680_-|pertactin-autotransporter
MNMSLSRIVKAAPLRRTTLAMALGALGAAPAAHADWNNQSIVKTGERQHGIHIQGSDPGGVRTASGTTIKVSGRQAQGILLENPAAELQFRNGSVTSSGQLFDDGIRRFLGTVTVKAGKLVADHATLANVGDTWDDDGIALYVAGEQAQASIAASTLQGAGGVQVERGANVTVQRSAIVDGGLHIGALQSLQPEDLPPSRVVLRDTNVTAVPASGAPAAVSVLGASELTLDGGHITGGRAAGVAAMQGAVVHLQRATIRRGDAPAGGGVPGGAVPGGFGPGGFGPVLDGWYGVDVSGSSVELAQSIVEAPELGAAIRVGRGARVTVSGGSLSAPHGNVIETGGARRFAPQAAPLSITLQAGAHAQGKALLYRVLPEPVQLTLTGGADAQGDIVATELPPIPGTSIGPLDVALASQARWTGATRAVDALSIDNATWVMTDNSNVGALRLASDGSVDFQQPAEAGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPRGSAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKVPPAPKPAPQPGPQPPQPPQPPQPPQPQPQPQPEAPAPQPPAGRELSAAANAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAGGAWGRGFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGRWHLGGLAGYTRGDRGFTGDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGRRFTHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW
>NZ_CP044089.1|WP_033453727.1|4915444_4916866_+|uroporphyrinogen-III-C-methyltransferase
MTLFPIFADLTGRRVLVVGGGAVAVRKTQALLQAGAEVVVGAPRLDPALAALAEQGGIARLDGGFEPAWLAGAWLVVAATDDRAVNAAVSEAARARRVFCNVVDDAELSSFQVPSVVDRSPLIVAISSSGVAPVLARRLRERIESLFDHSLGQLAALAARYRPRIRAARPDLGQRRRFYDWLLDGPVAARLRQQQPGLAEQELEQALRAPQAAPRGSVVLVGAGPGDPGLLTLKALRALNEADIILYDRLVSEGVLALARRDAERVPVGKLPGEDHDATQARIHALMLAQARAGRRVVRLKGGDAFIFGRGGEELEYLRAHDVPYEVVPGITAALACAAYAGIPLTHRDHAQSVRMVTAHCRADQDTLDWAGLARDQQTLAFYMGVGQLDYVTARLLEHGRAPATPFALIENGSRPEQRVVTGMLADLPEIARRRGVRPPALLVIGEVAALADTLQWFGQHQRGLPGPQALAA
>NZ_CP044089.1|WP_003809431.1|4914463_4915180_-|hypothetical-protein
MMVRFFVSIGVLAWAGAAQAGVCDAKFMHDGGQVQLTGSGNIGLGADLGFTEVSKTNGDNCRARVQGMATFSYAGLPPGKSRLDYLMTVKNGQATFVKYAEAGEQPRSEGQFDLRMLGLFAYDKISGEGQRLPGASYRLRIGKEAPVGGQPTTVVRIGEKTVGARQDLSTALGRHACWPITYPRSSEPTMATFKGLTLPIPGMDTTVTDWYCPSVNLVMRQDIDQAGIKSSVEITQLK
>NZ_CP044089.1|WP_003819780.1|4928509_4929238_-|phosphatase-PAP2-family-protein
MTAEPITAFPPPKSGLPGQGLAGLLRRCLVPVLLLLGCAAWLDRPLTLWINRSVSPQVNTVFDYIGNLGDSGTYVALGLAAYILGLQGMLRGWAVPWGWTCEKIARAGMLLLATLTAGGLATWVLKNVVARARPEVLLDDGIYGMGRMFAGNPFNSFPSSHTQTAFAVAAVLGILAPRWRWPALALAALVAISRVINRDHYLSDVCAAALIAVVAAYAIKPYVLSPRYTWPLRAPWRWRKRG
>NZ_CP044089.1|WP_003819779.1|4929394_4930822_+|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MQETTVKRDGASPSDAGTPATAAQGLGKLYIRTFGCQMNEYDSDKMADVLRADQGLELTDNPEDADVILFNTCSVREKAQEKVFSDLGRVQHLKKQNPNLVIGVGGCVASQEGEAIVKRAPYVDVVFGPQTLHRLPDLIKRRRAQGVSQVDISFPEIEKFDALPPPRVDGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPFDDVLLEVADLADQGVKEVTLLGQNVNAYRGAMGDSGKIADFAMLLEYVHEIPGIERIRYTTSHPKEMTQRMVDAYARLPKLVSFLHLPVQAGSDRVLAAMKRGYTALEFKSVVRRLRAARPSLTLSSDFIVGFPGETEEDFQKTMKLIEDVGFDTSFSFVYSRRPGTPAADLHDDTPQDVKLRRLQQLQALINQQAAAIAQGMIGTRQRVLVEGPSRRDPNELMGRTENNRIVNFPGVPRLIGHMVDVVVTHAHTNSLRGRVAGIERDTSGAE
>NZ_CP044089.1|WP_003809398.1|4930818_4931841_+|PhoH-family-protein
MSTSRSRARRTMPAIVNLDGDNIHLANLCGPLDENLRQLADGMGVKLARRGSRVTIEGEQAELAGRALRRFHEQATHRALSVDDIQLGLVEIGVGRPVEVQADPRELDQTLPPVDDESGGVVLRTRRTDLRPRTPRQRDYMNNILKHDITFGVGPAGTGKTWLAVACAIDAMERDTVQRLVLTRPAVEAGERLGFLPGDLAQKVDPYLRPLYDALYDLMGFERVQRLFEKQTIEIAPLAYMRGRTLNHAFVILDEAQNTTPEQMKMFLTRIGFGSKAVITGDPSQVDLPRGQQSGLAHAVQVLEEVQGIATTRFTSRDVVRHPLVARIVDAYDQAAANGD
>NZ_CP044089.1|WP_003809396.1|4931830_4932304_+|rRNA-maturation-RNase-YbeY
MATELSLSVQYGVADARLPRWRLRRWVQYALAGAAGDGHAGLAGAELGLRLVGLAEGRRLNREFRGRDYATNVLTFEYGTGPDGVARGDIVVCVPVLAREAREQRKTLLDHAAHLTVHGTLHALGYDHIKAGEARRMEALETAVLARMGIADPYLAA
>NZ_CP044089.1|WP_004568239.1|4932429_4933332_+|CBS-domain-containing-protein
MSAWTMSDPYPATEAHAQRAAKSSSKSLLDRLLSLVRREPEDREGIKAILEAAHERALLDAESYAMIKGALAVSERTVADIMVPRSRMDLLDISQPLPQLLATIIETAHSRFPVYEDDRDNIIGILLAKDLLRYMLEPALDIRSLVRPAVFIPEVKRLNVLLREFRASRNHLAIVIDEHGGISGLVTMEDVLEQIVGDIEDEFDEDEEESIFPEGENQWRLTASTDISHFNATFATDLPDDEYDSVGGWLGGQLGRIPRRGDSADHDGLHIEVVRADARRALWLRVRRNAGAQPPASAAE
>NZ_CP044089.1|WP_015041210.1|4933328_4934972_+|apolipoprotein-N-acyltransferase
MSPAGKGPAWRQPAILAAAGAAHALSFAPDPLPAWSLAPVQVIALAVAAHASLQAPSARRALARGWLFAMFSFSLGLYWLYVSMHDYGGLAAPLAAAGVLALSAFLALFPGLACAAARWLCPPHWDASPPARARRTLYTAATWAACWAALEWLRAVVLTGFPWLNIGYAHVDSPLAGWAPLLGVHGMALLAAFAAAALAGLWQSASGRIDSRQALAAGVALLLAGAGWLLGQFSWSRPEGKPLHLRLVQGNVEQSQKFDPALLETGLRRHLELASLPPRPGEPKPDLIILPETVLPVFQDQLPASVWDAWIEVARRADTRIAMGVPLHTQPDGATGHRYTNSVIGFDASTPVEQLRTGTTAMRYDKQHLVPWGEYVPPGFRWFVDMLDIPLGDFDRGAARQPSFDIAGQRIAFNICYEDLFGPELLPALQDGPDGRPGATIMANVSNLGWFGNTWALRQHLQIGRLRTMETARPMVAATNTGITAAIDARGRVAAALPADRAGVLPVAVQGMTGLTPYARFGDKPALALIGLLLIAAAARGRRPRQP
>NZ_CP044089.1|WP_003819773.1|4934968_4935976_-|aldo/keto-reductase
MRITRVGFGAWAIGGPGWSVGWGAQDDGESIRAIRHAVNRGINWIDTAAVYGLGHSESLVGRALAGMPPSERPYVFTKGGLVGSPADPMAKPRRIGAPDSLRREVEASLRRLGVEAIDLYQMHWPAGDGTPLEVYWQALLDLRQAGKVRHVGLSNHNLAQVQAAEQLGHVETLQPPFSAIRRESAADLLPWCASHDTGVIVYSPMQSGLLSGAFSAERAAALPEGDWRARNAEFMAPRLAANLEFADALKPIAQHHGASVGAIAVAWALAWPGVTGAIAGARSAEQVDGWLGAATLELDSDDMRQIADALARTGVGGGPLLPPPDEAALALTARP
>NZ_CP044089.1|WP_003809388.1|4936998_4937697_+|GntR-family-transcriptional-regulator
MKEKPITAIDKNGIDAPLTDVVYQRMLDGIYAGGLPPGGVINEVELAREFGVSRGPVREAVRRLQGIQIVTREPYMKARVVAMSAESALELFQMRMGLEGVACFLATQRMSDADIAQLQRDMDAHYQSWAARREGAPNGEERHFDLHERIVRASGNKRIIAALCEDLYHLLRIYRRHSGSALERKDDAYDEHWQIVRAIASRDARLAESLMRSHIERAANHVASQLREPAIQ
>NZ_CP044089.1|WP_003819771.1|4937693_4939079_+|hypothetical-protein
MTPALPAAPSDRFAAGLAEACQFVATLTWDAIPAAVRQRAVDVLCDDLAAMAAAAPEPELRRYAALLTARAGAAESPLISPALPRVGRMEAASWNALAGNWCELDEGFRLAICHAGIYTLPALLAEATATRARLREVLTALTGAYELVTRCAMSFHVMPPPVHGHALWSAVGAAAAVSLLRGHDAQTLLRAVSGAITTASMGPRSHLMAGVLIRNGWAAAGAVNGMQCADWAECGFGGAPASMEEVCAGIVKASLREGEITRELGTRWSLLHGYQKLYSCCQHGHSAVQACLALRADPAFEPDRVRAIRLDTHPLALTLDTVHPSTTLGARFSMPHMMAAALALGTGSAAAFSQSTLSDPAVAALREKVRMRLADAPMPAPHDRPAWLEVELDDGRVLRASCLSATGSPDNPVTPAQFEDKLARLGADVLPRLPQAIAPAAWQAALDEETGAWLAALARQA
>NZ_CP044089.1|WP_080704265.1|4939108_4940101_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MSRKFLSALRNAGMCGVMMLGGLAAAPAAADAWPGQPIRMVVPFAPGGAVDTLGRLVARQLTDVLGQSVVVENKPGAGGNIGSNIVAKAAPDGYTLLFGAAGNIAINPSLFDNMPFNVEKDLAPAALAGQSMNVLVVPAALPVNSVAELIDYARKHPDKLNYGSSGNGGTTHLAGELFNAMAGTRITHVPYQGSGPAMIDLLAGRVQLMFDNLPSAMPHIQRGDLKALGVTGAIRSPQLPDVPTIAETGLAGFEATTWFGVFAPAGTPQSVLERLNGAVNQVMQSAPVEQKLQSMAAYFQPTTRAQFQALIQDDTAKWARVIKAAGIKLN

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Crispr_ID: NZ_CP044089_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044089_13

5052341-5052415

Orphan

Consensus_repeat	Method
GGGACAGGCACCGTGCAGCGCAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044089_13

>merge|NZ_CP044089|13|5052341-5052415|CRISPRCasFinder
GGGACAGGCACCGTGCAGCGCAGCGTGGCATCCGGGTGCCTGTCCCCGTTGGGACAGGCACCGTGCAGCGCGGCG

>NZ_CP044089|13|12|5052341-5052415|CRISPRCasFinder
GGGACAGGCACCGTGCAGCGCAGCG	TGGCATCCGGGTGCCTGTCCCCGTT
GGGACAGGCACCGTGCAGCGCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044089.1\|WP_003809136.1\|5047646_5047979_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_080700633.1\|5050774_5052163_-\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP044089.1\|WP_033471920.1\|5043413_5044448_+\|polysulfide-reductase-NrfD	unknown	unknown	gnl\|CDD\|184954
NZ_CP044089.1\|WP_003809130.1\|5053836_5054340_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319910
NZ_CP044089.1\|WP_033470537.1\|5056232_5056856_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378278
NZ_CP044089.1\|WP_150349151.1\|5049765_5050773_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
NZ_CP044089.1\|WP_003819659.1\|5041008_5041935_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP044089.1\|WP_003819639.1\|5057940_5058360_+\|cyclase	unknown	unknown	gnl\|CDD\|273970
NZ_CP044089.1\|WP_003819654.1\|5048170_5049592_-\|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|224089
NZ_CP044089.1\|WP_003809146.1\|5041957_5042311_-\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|238008
NZ_CP044089.1\|WP_042993141.1\|5059065_5060088_+\|TRAP-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270321
NZ_CP044089.1\|WP_003809128.1\|5055159_5056236_+\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	unknown	unknown	gnl\|CDD\|185333
NZ_CP044089.1\|WP_003819653.1\|5049608_5049755_-\|DUF2474-family-protein	unknown	unknown	gnl\|CDD\|371167
NZ_CP044089.1\|WP_010927811.1\|5056852_5057143_+\|metal-binding-protein	unknown	unknown	unknown
NZ_CP044089.1\|WP_004568287.1\|5057180_5057708_+\|hemerythrin-domain-containing-protein	unknown	unknown	gnl\|CDD\|213983
NZ_CP044089.1\|WP_150349186.1\|5052502_5053669_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277331
NZ_CP044089.1\|WP_004568284.1\|5054441_5055101_+\|DNA-3-methyladenine-glycosylase-2-family-protein	unknown	unknown	gnl\|CDD\|223200
NZ_CP044089.1\|WP_033454825.1\|5058410_5059031_+\|2-hydroxychromene-2-carboxylate-isomerase	unknown	unknown	gnl\|CDD\|239320
NZ_CP044089.1\|WP_015041173.1\|5044474_5047636_+\|tetrathionate-reductase-subunit-TtrA	unknown	unknown	gnl\|CDD\|237883
NZ_CP044089.1\|WP_003819657.1\|5042626_5043400_+\|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl\|CDD\|184955

Protein	Function_ID	Function_description	E-value
NZ_CP044089.1\|WP_080700633.1\|5050774_5052163_-\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NZ_CP044089.1\|WP_033471920.1\|5043413_5044448_+\|polysulfide-reductase-NrfD	gnl\|CDD\|184954	PRK14992, PRK14992, tetrathionate reductase subunit TtrC.	6.25508e-43
NZ_CP044089.1\|WP_033470537.1\|5056232_5056856_+\|hypothetical-protein	gnl\|CDD\|378278	pfam09859, Oxygenase-NA, Oxygenase, catalyzing oxidative methylation of damaged DNA. This family of bacterial sequences is predicted to catalyze oxidative de-methylation of damaged bases in DNA.	1.90584e-50
NZ_CP044089.1\|WP_150349151.1\|5049765_5050773_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	5.09023e-99
NZ_CP044089.1\|WP_003819659.1\|5041008_5041935_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.03606e-26
NZ_CP044089.1\|WP_003819639.1\|5057940_5058360_+\|cyclase	gnl\|CDD\|273970	TIGR02096, putative_cyclase, conserved hypothetical protein, steroid delta-isomerase-related. This family of proteins about 135 amino acids in length largely restricted to the Proteobacteria. This family and a delta5-3-ketosteroid isomerase from Pseudomonas testosteroni appear homologous, especially toward their respective N-termini. Members, therefore, probably are enzymes.	1.23413e-52
NZ_CP044089.1\|WP_003809130.1\|5053836_5054340_+\|VOC-family-protein	gnl\|CDD\|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.40007e-55
NZ_CP044089.1\|WP_003809146.1\|5041957_5042311_-\|EF-hand-domain-containing-protein	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	6.77115e-08
NZ_CP044089.1\|WP_042993141.1\|5059065_5060088_+\|TRAP-transporter-substrate-binding-protein	gnl\|CDD\|270321	cd13603, PBP2_TRAP_Siap_TeaA_like, Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP) and related proteins; the type 2 periplasmic-binding protein fold. This subfamily includes the periplasmic-binding component of TRAP transport systems such as SiaP (a sialic acid binding virulence factor), TeaA (an ectoine binding protein), and an uncharacterized TM0322 from hyperthermophilic bacterium Thermotoga maritima. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.28392e-123
NZ_CP044089.1\|WP_003809128.1\|5055159_5056236_+\|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	6.29763e-138
NZ_CP044089.1\|WP_003819653.1\|5049608_5049755_-\|DUF2474-family-protein	gnl\|CDD\|371167	pfam10617, DUF2474, Protein of unknown function (DUF2474). This family of short proteins has no known function.	2.47299e-05
NZ_CP044089.1\|WP_004568287.1\|5057180_5057708_+\|hemerythrin-domain-containing-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	1.38579e-12
NZ_CP044089.1\|WP_150349186.1\|5052502_5053669_+\|metallophosphoesterase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.97711e-80
NZ_CP044089.1\|WP_004568284.1\|5054441_5055101_+\|DNA-3-methyladenine-glycosylase-2-family-protein	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	1.35503e-52
NZ_CP044089.1\|WP_033454825.1\|5058410_5059031_+\|2-hydroxychromene-2-carboxylate-isomerase	gnl\|CDD\|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	9.44875e-77
NZ_CP044089.1\|WP_003819657.1\|5042626_5043400_+\|4Fe-4S-dicluster-domain-containing-protein	gnl\|CDD\|184955	PRK14993, PRK14993, tetrathionate reductase subunit TtrB.	3.36133e-131
NZ_CP044089.1\|WP_015041173.1\|5044474_5047636_+\|tetrathionate-reductase-subunit-TtrA	gnl\|CDD\|237883	PRK14991, PRK14991, tetrathionate reductase subunit TtrA.	0
NZ_CP044089.1\|WP_003819654.1\|5048170_5049592_-\|PLP-dependent-aminotransferase-family-protein	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.75526e-136

>NZ_CP044089.1|WP_080700633.1|5050774_5052163_-|cytochrome-ubiquinol-oxidase-subunit-I
MMSSEALLLARIQFGFTISFHIIFPAITIGLASYLAVLEGCWLRTRDTVYRDLYHFWSKVFAVNFGMGVVSGLVMAYQFGTNWSAFSEFAGSITGPLLAYEVLTAFFLEAGFLGVMLFGWSRVGPRLHFFSTIMVALGTLVSATWILASNSWMQTPAGYEIVDGRVVPVDWLAVIFNPSFPYRLAHMGIAAFLATALLVAASGAWHLLRGHRTPAVRRMFAMALGMLAIAAPLQAVVGDMHGINTLKHQPAKIAAIEGHWENVPGEGVPLHLFGVPDMQAETTRYALSVPRLGSLILTHSLDGQFPGLKSYPPADRPNATVVFWSFRVMVGLGLLAIALAAWAGWARLRGRLYDSRALQRFALAMGPSGLVAILAGWYTTEIGRQPWIVQGLMRTADAATPHGVPALTLTLLLFVFVYLIVFGAGIVYVLRLIARGPSGSAPAGGEPGLVQRPLAAAQQGGL
>NZ_CP044089.1|WP_150349151.1|5049765_5050773_-|cytochrome-d-ubiquinol-oxidase-subunit-II
MGVDLSLIWAIIILFGVMMYVVMDGFDLGIGVLFPLLPGKSDRDVMMNTVAPVWDGNETWLVLGGAGLLAAFPRAYAVVLGALYLPLVFMLLGLVFRGVAFEFRFKADEHHRPFWDRAFIGGSVAAAFFQGATLGAYLQGIDLVDGAYQGGPWGWVTPFSLFCGAGLVVAYALLGCTWIIMKTEGALQRRMIVVARPLTGALLAVIAVISVWTPLIEPAIARRWFSLPNFYAFAPVPVLVLAAAWGLLRALRGQPDMAPFLLTLALVFLGYSGLCISLWPHAIPPGVTLWEAAAPPQSQGFALVGALFIVPIILTYTAWSYYVFRGKVRAGDGYH
>NZ_CP044089.1|WP_003819653.1|5049608_5049755_-|DUF2474-family-protein
MTEDTLDRPASTLRRLGWLALLWAGGVAGLGLAAGGLKLIMKLAGLTP
>NZ_CP044089.1|WP_003819654.1|5048170_5049592_-|PLP-dependent-aminotransferase-family-protein
MKLKRYEVLADEITASIQAGTRRAGDRLPSVRQTSASRGLSATTVFKAYYLLEARGLIRARDRSGYYVVGKPKALPPELEAGAPAESRRVDVDVSDRVLHVLQLTMRRDVVPFGSAFPHPSLFPHARLARAMASSVAALDPWSSVDDLSAGNTRLRRAIALRYLADGVQVRTEDIVITNGALEALNLCLGAVTRPGDSVLIESPTFYSALQSLERLGLRAIEVPAHPREGIELDALARAIDTHRPAACWLMTNFQNPLGSLMPEDKKRALVELLAARDVPLIEDDVYSELYFGAQRPLPAKAYDESGIVMSCSSFSKSLAPGWRIGWVLGGRYADRILRGKLALSLSTSAPSQAALATYLEHGGYDRHLRQLRQTLEQQRNQVMEAIARHFPPGTRTTHPDGGYFLWVALPPQVDALAVHRAALSLGVSTAPGPIFSVQDRFRHCLRLNYGHPFDARAQDGLATLGKLIARQC
>NZ_CP044089.1|WP_003809136.1|5047646_5047979_-|hypothetical-protein
MYRGHEAIKQFMQAIGLPWTPGQAESAELRASYRIGSGRPLNIDRTRVEFHCDDARAKVWVPEFARTSFHQWFEVAYQDFEYAPGASMLKIKAAARGNAAAYSVGLKPLA
>NZ_CP044089.1|WP_015041173.1|5044474_5047636_+|tetrathionate-reductase-subunit-TtrA
MPKQHPTPDTDAPADARRRKLIARGGAVAGGMAAFAAGYGETVARAVKGLAQGSAGAPTADALRGNSLTPEFRIDPVTGALSAQPGQTVSPSSCLGCWTQCGVRLRVDTETNRILRVAGNPYHPLATTQPAPMHAPVREVYARLGGDNGLEGRATSCARGSAMLEQLTSPYRVLQPLKRVGPRGAGQWRTISFEQLVEEVCEGGDLFGEGHVDGLRAIYDPVTPLDPDNPEYGPRSNQLLFTDSANEGRTPLIQRFAAQSFGTVNVSNHGSYCGQSFRVGTGAAFGDLKGMPHGKPDWTRARFGLFIGTAPAQSGNPFQRQGRQLAEARVRDDGAGFHYVVVSPVLPASASLAAGSGNEWLAVNPAGDLALVMGMIRWILEHDRYDAAMLSQPGPAAMDAAGEAAWTNATHLVIDAPGHARHGSCLRGADLGWPRAGADPQAEDVYVVQRPDGTLAPHTHAGPAALFVERDLPAAGVAPGLGGVRASSALALLRREARRMTLDEYARHSGVPAARIAGLAERFTSHGKQAVADAHGGTMSGAGFYTAYAIAMLNTLVGNLNVAGGLVLDGGPFAPYGKGPRYDIAGFAGRVAPRGVSLSRNRFPYEKSSEYRRKAEAGQSPYPAQSPWYPATGALSSEMLASALAGYPYRAKVWLNHMSNPVYAIAGLKNVIADKLRDPGLLPLSVSINAFINETNALADYIVPDTITYESWGVSAPWADVQAKASTVRWPAVAPRVARTANGEPVCLESFLIACAKRLGMPGFGADAIAGRDGRRHALDTASDFFLRGMANMAYAGGAPVAEASEDDLALTGVDRHADLLRRTLQDDEWRRVALLMSRGGRFDAAEDVWREGRVHPPYRKPLHVWSEDLARMRHAMTGEPYSGCPTWYPTRLADGRAMREQYPQADWPFLLSSFKSNLMSSMSIGVSRLRQVHPHNPVSISRADASRLGIGNGDAVRIVTPGGAVTGLALVRDGVQPGAIAIEHGYGHTELGARAHVVDGRPMPHDPALAAGVNLNDLGFGDATRALRDNVWIDWVSGAAVRQGLPARLEKA
>NZ_CP044089.1|WP_033471920.1|5043413_5044448_+|polysulfide-reductase-NrfD
MRISELITPVYDAAWLPWAVQYFFLIGISAATALTAAACAFGRPGSARARLLPAAIAVLAVSAVAAPVSLLADLHQPGRFWHFYTQATPWSWMWLGALLLPLYAALALGLCAAWWLGWRRAMRALAVPLALSALSILVYTGSEVMVLRSRPLWHTVFLPINFALTGWLGALGAMLLLGRWLPGDLAAVPMALLRRLAMAALAALAASAGAWAVLGLLGHEPSFDAALRLFAQFPAWRASLAGAIATGLCMAALLQMRPARLAGPAASLALALTLLAAAWIFRWVVFMNVQGVPKYGAGLYLYDMPWGSDGLLGMAGVLGLCVALVAALAWALERFPARTAAPAR
>NZ_CP044089.1|WP_003819657.1|5042626_5043400_+|4Fe-4S-dicluster-domain-containing-protein
MHNAPSSDRPPAPGKRGFLKELLGLAATATVIPIAPEARAGMNAQPPRRPGAAGKRYGMVVDLRLCIGCQACTVSCSMENLPPIGQFRTTVLQYEVLPDDGGPCSMVMLPRLCNHCDNPPCVPVCPVQATFQREDGIVLVDNERCVGCGYCVQACPYDARFINHETQTADKCTFCEHRLEAGLLPACVESCVGGARVIGDLNDPASAVSRLLAEHRDEVKVLKPDMRTDPHVYYIGLPDAFVNQIDGQAGVRLAGRH
>NZ_CP044089.1|WP_003809146.1|5041957_5042311_-|EF-hand-domain-containing-protein
MKKTIIASAACAALLATSGAVLAQSGASLTPDQLQHLDTDKSGGVSQKEYQAFMEASFAKLDANGDGSLTRQELPQEVSDAQFTAMDANKDGRVSRQEFLGQVMRDFATASRGGELK
>NZ_CP044089.1|WP_003819659.1|5041008_5041935_+|alpha/beta-hydrolase
MTQSSQTTSPSADAHVKHRYLDLDELRIFYREAGPADAPVVLLPHGYPCSSFQYRDFMPALADQWRLLAPDFPGFGYSDTPDTARFACDFEHYTDFLQQFAHALGLPSYALYLHDYGSQIGLRLAMREPDKVSGLIIQNGDIYEDELGPRYAPLQAYWADPTLEGRYKLSLAVSEEGFRDEFLNDLPEEQAECITPDMWKLAWALLREPRRREIMVGLMEGLEDNLAWFPRYQAYLRERQPPTLIVWGVHDGYMPEAAARAYLRDLPDAELHLLQAGHWALETHLAPIVALTRAFLQRVHATPNFPPP
>NZ_CP044089.1|WP_150349186.1|5052502_5053669_+|metallophosphoesterase
MSLRRSAFFIRFLTLGALAHVYVGARLIPDAGLPAAGVAAAILALCASCVLIPLGMASHASGRQPWGDRLAAVGLVAMGYFSSLFVLTVLRDAALLLAWLAWLAALAALPVPMDALRAASAPAVPLLALAATLLGLANARRRARVVTVDVPIDALPAALQGYTIVQISDLHVGPTIKRRYLQAIVDAVNAAGPDLVAVTGDVVDGPVAHLSPHTQPLAALRAPDGVYLVTGNHEYYSGAAAWVQEFRRLGLCVLQNEHRVVRRGDAALVVAGVTDYGAAAFDASQRSNPAQALAGAPAKAAVRLLLAHQPRSAAAAAPLGYTLQLSGHTHGGQFLPWNWFVRLQQPFTAGLHRYGPMWVYTSRGTGYWGPPKRLGAPSEITRVRLVRA
>NZ_CP044089.1|WP_003809130.1|5053836_5054340_+|VOC-family-protein
MATAVKPIPEGMHTLTPHIICAGAARAIDFYIKAFGAVEMARLAGPDGRLMHGAVRIGDSTLMLMDAFPEWDTPDPKALNGTPVVLHLYVEDVDAAHAQAVAAGATSVMPVTDMFWGDRYGQVRDPFGHLWSIATHKQDLTPEQIAEAARNAPPCPDVAEQAGKARE
>NZ_CP044089.1|WP_004568284.1|5054441_5055101_+|DNA-3-methyladenine-glycosylase-2-family-protein
MTAATLSPAAYAHAERFLAGLDADWRGHVAATGPCLHRPLPAREPYEALVRAIAYQQLHARAGDAIVGRLLALFPGGAFPAPGQLLAADPAALRACGFSAAKTQTILGIAQAARDGVVPDRRAARRMSDQALVERLTTLRGVGRWTVEMLLIYTLARADILPADDFGVRDGYRRLKGAAATPTARQMRDIGQAWGPYRTLAAWYLWRVPPEARIRAQET
>NZ_CP044089.1|WP_003809128.1|5055159_5056236_+|bifunctional-DNA-binding-transcriptional-regulator/O6-methylguanine-DNA-methyltransferase-Ada
MNLPVRPAPAYATPEARWAAVQARDPAADSHFVYAVRTTGVYGRPSSAARLPRRENVEFFDNAEAARAAGYRPSRHNAADRTVTARQHSALVAAACRHIEQADTPPTLEALAAHVGLSPFHLHRLFKAETGLTPKAYASAQRARRLRAELGESASVTAAIYDAGFNSNSRFYEASQQLLGMAPRAYRAGGANARIRFAVAQCALGAILVAQSQLGICAILLDDDPDYLVRQLQDLFPRATLIGGDAGFERLVAEVVGFVEAPALGLNLPLDVRGTAFQERVWQALREVPPGATVSYTDIAERIGAPKAVRAVAQACAANRIAVAIPCHRVVRRDGDLSGYRWGVDRKRELLRREAATP
>NZ_CP044089.1|WP_033470537.1|5056232_5056856_+|hypothetical-protein
MTPDILQAGATAIAALDRAALHARLDRDGWALLPALFDAPAIAALLACAPPQGPGIAAGVFAPLRAALYAQLAPLANAWAQTLQTGWRYPASAPAGVPPDIRLDVVEAGHARPLTQHEPAPDVFPLQLVVLLSDPKRDFAGGELVLTEQRPRMQSRPIVIPLRQGDAALIPTAHRPCRGAHGFYRASLRQAISPVRAGRRVGLALLP
>NZ_CP044089.1|WP_010927811.1|5056852_5057143_+|metal-binding-protein
MSPSARRWRLIGADGQPLLSAEPGTLGGHRRGRLYGRLDCRAAARALARGGYAAQRVFFLDEASAVAAGYRPCAVCMPQAYAAWKTARAHKRAAME
>NZ_CP044089.1|WP_004568287.1|5057180_5057708_+|hemerythrin-domain-containing-protein
MSSAFPAPAPDFDQPLQLLAACHGRIERQCATLERLAAHLRAQGSDDAARTAAASVMRYFDSAAVKHHEDEEQDLFPALIESMAGSDAVCLRQLVGSLTDEHRALGSAWRRVREVLQQVADGQGAAFAPGQAEDFVAAYRAHLRREDEELLPLAERLLDDGALADMAQAMRDRRS
>NZ_CP044089.1|WP_003819639.1|5057940_5058360_+|cyclase
MTWRVDLIAQHIEVENRHLMDEMLATLADENPVRDEVAGRVYRGKDQVAARYAELWQAFPDFNVRPVRYTEQEGIVVMEAIYTGTHHGAYLGLPGSGKSFNVRLVNVFGFDDERIESETIYIDLAGQLRQLGITAIPRN
>NZ_CP044089.1|WP_033454825.1|5058410_5059031_+|2-hydroxychromene-2-carboxylate-isomerase
MHIDYYFSVVSDWAYFGGERLERLARRHGATIRHKPMQLSAVYAQTGGILLQQRSTQRQAYRVTELERWRDHLGIPITLHPRHYPVDDIPASCAILAAQELGMATGDYANAVLRAIWTQERDISDPRTLDEIARGLGLDADAILQLAQAPHIRQRLADNTREAIGHGVFGSPFYLCNGHLFWGQDRLPFLEDVLAGRVGAYAGAPA
>NZ_CP044089.1|WP_042993141.1|5059065_5060088_+|TRAP-transporter-substrate-binding-protein
MLRTARTTLAIIAAATLLAACDKGGADRPQAASGAQPRTLQLAHVSVENEDDMYHHLAAGFAERVARHTNGAVKVQVLGGAQLGGERDVAEGMQLGSIDMSVIASFALGAFEKKAMIFDLPYLFKDYPTAFQALDSSFTDGIEADLEKTGLKVLGWGHGGFRNLYNSKQPIRTLADLKDMKVRMPENPIYVDTWRALGVNVTSMAYPELFTGLQQRTIDGAENPTALYYTSRFYEAAKYLSKTEHVYVAIPIVVSARIWTSLAPEQQAAFQQAADEAIAAQRQFLLATEAATEKKLAEAGVAINTDVDKAAFRQAAAPVYERYRNTIDPELVNRAQALAQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP044089_2	2.1\|1650370\|38\|NZ_CP044089\|CRISPRCasFinder	1650370-1650407	38	NZ_CP044089.1	515960-515997	0	1.0
NZ_CP044089_2	2.1\|1650370\|38\|NZ_CP044089\|CRISPRCasFinder	1650370-1650407	38	NZ_CP044089.1	1743967-1744004	0	1.0
NZ_CP044089_2	2.1\|1650370\|38\|NZ_CP044089\|CRISPRCasFinder	1650370-1650407	38	NZ_CP044089.1	4598749-4598786	0	1.0
NZ_CP044089_5	5.1\|3424867\|37\|NZ_CP044089\|CRISPRCasFinder	3424867-3424903	37	NZ_CP044089.1	434380-434416	0	1.0
NZ_CP044089_6	6.1\|3425047\|16\|NZ_CP044089\|CRISPRCasFinder	3425047-3425062	16	NZ_CP044089.1	3425008-3425023	0	1.0
NZ_CP044089_2	2.1\|1650370\|38\|NZ_CP044089\|CRISPRCasFinder	1650370-1650407	38	NZ_CP044089.1	3803829-3803866	1	0.974
NZ_CP044089_2	2.1\|1650370\|38\|NZ_CP044089\|CRISPRCasFinder	1650370-1650407	38	NZ_CP044089.1	2774617-2774654	1	0.974
NZ_CP044089_2	2.1\|1650370\|38\|NZ_CP044089\|CRISPRCasFinder	1650370-1650407	38	NZ_CP044089.1	4778210-4778247	1	0.974
NZ_CP044089_5	5.1\|3424867\|37\|NZ_CP044089\|CRISPRCasFinder	3424867-3424903	37	NZ_CP044089.1	2178316-2178352	1	0.973

1. spacer 2.1|1650370|38|NZ_CP044089|CRISPRCasFinder matches to position: 515960-515997, mismatch: 0, identity: 1.0

ataccgtcttggcggtcaagcgtcgatggcgtacggca	CRISPR spacer
ataccgtcttggcggtcaagcgtcgatggcgtacggca	Protospacer
**************************************

2. spacer 2.1|1650370|38|NZ_CP044089|CRISPRCasFinder matches to position: 1743967-1744004, mismatch: 0, identity: 1.0

ataccgtcttggcggtcaagcgtcgatggcgtacggca	CRISPR spacer
ataccgtcttggcggtcaagcgtcgatggcgtacggca	Protospacer
**************************************

3. spacer 2.1|1650370|38|NZ_CP044089|CRISPRCasFinder matches to position: 4598749-4598786, mismatch: 0, identity: 1.0

ataccgtcttggcggtcaagcgtcgatggcgtacggca	CRISPR spacer
ataccgtcttggcggtcaagcgtcgatggcgtacggca	Protospacer
**************************************

4. spacer 5.1|3424867|37|NZ_CP044089|CRISPRCasFinder matches to position: 434380-434416, mismatch: 0, identity: 1.0

ataccgtcttggccgtcgcgtcgatggcgtacggcag	CRISPR spacer
ataccgtcttggccgtcgcgtcgatggcgtacggcag	Protospacer
*************************************

5. spacer 6.1|3425047|16|NZ_CP044089|CRISPRCasFinder matches to position: 3425008-3425023, mismatch: 0, identity: 1.0

aggctagaagtttgcg	CRISPR spacer
aggctagaagtttgcg	Protospacer
****************

6. spacer 2.1|1650370|38|NZ_CP044089|CRISPRCasFinder matches to position: 3803829-3803866, mismatch: 1, identity: 0.974

ataccgtcttggcggtcaagcgtcgatggcgtacggca	CRISPR spacer
atgccgtcttggcggtcaagcgtcgatggcgtacggca	Protospacer
**.***********************************

7. spacer 2.1|1650370|38|NZ_CP044089|CRISPRCasFinder matches to position: 2774617-2774654, mismatch: 1, identity: 0.974

ataccgtcttggcggtcaagcgtcgatggcgtacggca	CRISPR spacer
ataccgtcttggcggtgaagcgtcgatggcgtacggca	Protospacer
**************** *********************

8. spacer 2.1|1650370|38|NZ_CP044089|CRISPRCasFinder matches to position: 4778210-4778247, mismatch: 1, identity: 0.974

ataccgtcttggcggtcaagcgtcgatggcgtacggca	CRISPR spacer
ataccgtcttggcggccaagcgtcgatggcgtacggca	Protospacer
***************.**********************

9. spacer 5.1|3424867|37|NZ_CP044089|CRISPRCasFinder matches to position: 2178316-2178352, mismatch: 1, identity: 0.973

ataccgtcttggccgtcgcgtcgatggcgtacggcag	CRISPR spacer
ataccgtcttggccgtcgcgtcgatggcgtacggtag	Protospacer
**********************************.**

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP044089_8	8.1\|3896846\|25\|NZ_CP044089\|CRISPRCasFinder	3896846-3896870	25	MN871474	UNVERIFIED: Pseudomonas virus Pa-oumiga, complete genome	9841-9865	5	0.8
NZ_CP044089_8	8.1\|3896846\|25\|NZ_CP044089\|CRISPRCasFinder	3896846-3896870	25	MN871471	UNVERIFIED: Pseudomonas virus Pa-V, complete genome	9840-9864	5	0.8
NZ_CP044089_8	8.1\|3896846\|25\|NZ_CP044089\|CRISPRCasFinder	3896846-3896870	25	MN871472	UNVERIFIED: Pseudomonas virus Pa-X, complete genome	8748-8772	5	0.8
NZ_CP044089_12	12.1\|4928374\|30\|NZ_CP044089\|CRISPRCasFinder	4928374-4928403	30	NZ_CP036297	Planctomycetes bacterium Pla86 plasmid pPla86_1, complete sequence	15781-15810	6	0.8
NZ_CP044089_12	12.1\|4928374\|30\|NZ_CP044089\|CRISPRCasFinder	4928374-4928403	30	NZ_CP036288	Planctomycetes bacterium Pla133 plasmid pPla133_1, complete sequence	15811-15840	6	0.8
NZ_CP044089_12	12.1\|4928374\|30\|NZ_CP044089\|CRISPRCasFinder	4928374-4928403	30	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3259733-3259762	7	0.767
NZ_CP044089_7	7.1\|3652137\|31\|NZ_CP044089\|CRISPRCasFinder	3652137-3652167	31	NZ_CP014361	Methylomonas sp. DH-1 plasmid, complete sequence	70178-70208	8	0.742
NZ_CP044089_12	12.1\|4928374\|30\|NZ_CP044089\|CRISPRCasFinder	4928374-4928403	30	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	377581-377610	8	0.733
NZ_CP044089_12	12.1\|4928374\|30\|NZ_CP044089\|CRISPRCasFinder	4928374-4928403	30	NZ_CP031079	Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence	182786-182815	8	0.733
NZ_CP044089_12	12.1\|4928374\|30\|NZ_CP044089\|CRISPRCasFinder	4928374-4928403	30	NC_047851	Brevibacterium phage LuckyBarnes, complete genome	21375-21404	8	0.733
NZ_CP044089_7	7.1\|3652137\|31\|NZ_CP044089\|CRISPRCasFinder	3652137-3652167	31	NZ_CP054609	Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed1, complete sequence	92782-92812	9	0.71

1. spacer 8.1|3896846|25|NZ_CP044089|CRISPRCasFinder matches to MN871474 (UNVERIFIED: Pseudomonas virus Pa-oumiga, complete genome) position: , mismatch: 5, identity: 0.8

ataccgtcttcgatggcgcacggca	CRISPR spacer
tgggcgtcttcgatggcgctcggca	Protospacer
  . *************** *****

2. spacer 8.1|3896846|25|NZ_CP044089|CRISPRCasFinder matches to MN871471 (UNVERIFIED: Pseudomonas virus Pa-V, complete genome) position: , mismatch: 5, identity: 0.8

ataccgtcttcgatggcgcacggca	CRISPR spacer
tgggcgtcttcgatggcgctcggca	Protospacer
  . *************** *****

3. spacer 8.1|3896846|25|NZ_CP044089|CRISPRCasFinder matches to MN871472 (UNVERIFIED: Pseudomonas virus Pa-X, complete genome) position: , mismatch: 5, identity: 0.8

ataccgtcttcgatggcgcacggca	CRISPR spacer
tgggcgtcttcgatggcgctcggca	Protospacer
  . *************** *****

4. spacer 12.1|4928374|30|NZ_CP044089|CRISPRCasFinder matches to NZ_CP036297 (Planctomycetes bacterium Pla86 plasmid pPla86_1, complete sequence) position: , mismatch: 6, identity: 0.8

gcccgatgcgcgaggtgcctgtccccgctt	CRISPR spacer
ccccttggcgagaagtgcctgtccccgctt	Protospacer
 ***   *** **.****************

5. spacer 12.1|4928374|30|NZ_CP044089|CRISPRCasFinder matches to NZ_CP036288 (Planctomycetes bacterium Pla133 plasmid pPla133_1, complete sequence) position: , mismatch: 6, identity: 0.8

gcccgatgcgcgaggtgcctgtccccgctt	CRISPR spacer
ccccttggcgagaagtgcctgtccccgctt	Protospacer
 ***   *** **.****************

6. spacer 12.1|4928374|30|NZ_CP044089|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.767

gcccgatgcgcgaggtgcctgtccccgctt	CRISPR spacer
tcgcagtgcccgaggtgccagtccccgctc	Protospacer
 * *..*** ********* *********.

7. spacer 7.1|3652137|31|NZ_CP044089|CRISPRCasFinder matches to NZ_CP014361 (Methylomonas sp. DH-1 plasmid, complete sequence) position: , mismatch: 8, identity: 0.742

gtcatgcgccatgaacgcttgaccaccagga	CRISPR spacer
gtcatgcaccatgatcgcttgaccaaagtat	Protospacer
*******.****** **********  . .

8. spacer 12.1|4928374|30|NZ_CP044089|CRISPRCasFinder matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 8, identity: 0.733

gcccgatgcgcgaggtgcctgtccccgctt	CRISPR spacer
tcgagatgcgcgaggtgccggtgcccgacg	Protospacer
 *  *************** ** **** .

9. spacer 12.1|4928374|30|NZ_CP044089|CRISPRCasFinder matches to NZ_CP031079 (Paracoccus yeei strain CCUG 32053 plasmid pYEE1, complete sequence) position: , mismatch: 8, identity: 0.733

gcccgatgcgcgaggtgcctgtccccgctt	CRISPR spacer
tgctggggcgcgaggtgcatgtccccgccc	Protospacer
  *.*. *********** *********..

10. spacer 12.1|4928374|30|NZ_CP044089|CRISPRCasFinder matches to NC_047851 (Brevibacterium phage LuckyBarnes, complete genome) position: , mismatch: 8, identity: 0.733

gcccg---atgcgcgaggtgcctgtccccgctt	CRISPR spacer
---cggacatgcgcgaggtggctgtcccccgca	Protospacer
   **   ************ ********  .

11. spacer 7.1|3652137|31|NZ_CP044089|CRISPRCasFinder matches to NZ_CP054609 (Paenibacillus cellulosilyticus strain KACC 14175 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.71

gtcatgcgccatgaacgcttgaccaccagga	CRISPR spacer
cagaatcgcgatgaacgcttgatcaccagat	Protospacer
   *  *** ************.******.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3017575 : 3094030

Pseudomonas_phage(16.67%)

head,integrase,terminase,capsid,tail,protease,portal,tRNA

attL 3055419:3055469|attR 3096851:3096901

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003820400.1\|3017575_3017890_+\|protease	ATP-dependent Clp protease adapter ClpS	A0A1B1IT64	uncultured_Mediterranean_phage	1.2e-10	43.8
WP_150348982.1\|3017979_3023169_+	alpha-2-macroglobulin family protein	NA	NA	NA	NA
WP_033459775.1\|3023165_3025334_+	penicillin-binding protein 1C	NA	NA	NA	NA
WP_003812866.1\|3025353_3027702_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpA	A0A223W0B1	Agrobacterium_phage	1.9e-164	41.8
WP_003820402.1\|3027706_3029026_+	PqiA/YebS family transporter subunit	NA	NA	NA	NA
WP_003820404.1\|3029044_3030718_+	MCE family protein	NA	NA	NA	NA
WP_004567487.1\|3030722_3031391_+	membrane integrity-associated transporter subunit PqiC	NA	NA	NA	NA
WP_003820408.1\|3031547_3035369_+	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	NA	NA	NA	NA
WP_003812857.1\|3035622_3036768_+	branched-chain amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_003820410.1\|3036916_3037846_+	branched-chain amino acid ABC transporter permease	NA	NA	NA	NA
WP_033464799.1\|3037842_3038931_+	ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_003812849.1\|3038927_3039731_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.0e-13	23.9
WP_003812846.1\|3039727_3040459_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.9e-08	23.5
WP_010931108.1\|3040516_3041806_-	MFS transporter	NA	NA	NA	NA
WP_003820412.1\|3041902_3042505_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_150348983.1\|3042744_3045720_+	autotransporter BapC	NA	NA	NA	NA
WP_003820413.1\|3045782_3047021_-	ammonium transporter	H8ZJB2	Ostreococcus_tauri_virus	9.0e-25	30.5
WP_003812839.1\|3047046_3047385_-	P-II family nitrogen regulator	NA	NA	NA	NA
WP_150348984.1\|3048092_3048359_+	accessory factor UbiK family protein	NA	NA	NA	NA
WP_033465833.1\|3048465_3049968_+	YifB family Mg chelatase-like AAA ATPase	NA	NA	NA	NA
WP_003812834.1\|3050303_3050501_+	50S ribosomal protein L35	NA	NA	NA	NA
WP_003812832.1\|3050516_3050876_+	50S ribosomal protein L20	NA	NA	NA	NA
WP_010926359.1\|3050950_3051973_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2H4UW22	Bodo_saltans_virus	1.0e-26	38.6
WP_150348985.1\|3051985_3054403_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_003812826.1\|3054408_3054750_+	integration host factor subunit alpha	A0A0H3UZA0	Geobacillus_virus	2.8e-13	42.2
WP_003812822.1\|3054808_3055219_+	MerR family transcriptional regulator	NA	NA	NA	NA
3055419:3055469	attL	NA	NA	NA	NA
WP_033839544.1\|3055543_3056692_-\|integrase	tyrosine-type recombinase/integrase	A0A059VF45	Pseudomonas_phage	2.9e-134	61.8
WP_150348986.1\|3056951_3057611_-	hypothetical protein	Q5QF30	Pseudomonas_virus	3.2e-37	43.5
WP_050484706.1\|3059154_3059625_-	hypothetical protein	NA	NA	NA	NA
WP_150349175.1\|3059860_3060220_-	hypothetical protein	NA	NA	NA	NA
WP_150348987.1\|3060252_3060531_-	hypothetical protein	NA	NA	NA	NA
WP_150348988.1\|3060527_3061349_-	hypothetical protein	NA	NA	NA	NA
WP_150348989.1\|3061345_3062293_-	hypothetical protein	A0A0U4JP11	Pseudomonas_phage	2.3e-41	42.6
WP_126438240.1\|3062295_3062523_-	hypothetical protein	NA	NA	NA	NA
WP_126438241.1\|3062842_3063082_-	hypothetical protein	NA	NA	NA	NA
WP_126438242.1\|3063123_3063741_-	hypothetical protein	NA	NA	NA	NA
WP_068957830.1\|3063948_3064191_-	hypothetical protein	NA	NA	NA	NA
WP_150348990.1\|3064225_3064627_-	hypothetical protein	NA	NA	NA	NA
WP_150348991.1\|3064682_3065138_-	hypothetical protein	NA	NA	NA	NA
WP_050489230.1\|3065451_3066183_-	helix-turn-helix transcriptional regulator	J7I4M9	Acinetobacter_phage	9.3e-30	35.8
WP_150348992.1\|3066283_3066556_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_033466657.1\|3066661_3067192_+	hypothetical protein	C7BGG0	Burkholderia_phage	2.0e-10	32.9
WP_150348993.1\|3067486_3067789_+	hypothetical protein	NA	NA	NA	NA
WP_150348994.1\|3067785_3068274_+	DUF1364 family protein	NA	NA	NA	NA
WP_150348995.1\|3068270_3069461_+	replication protein	K7PGT1	Enterobacteria_phage	1.3e-12	43.2
WP_150348996.1\|3069457_3070852_+	replicative DNA helicase	A0A077SK18	Escherichia_phage	5.5e-71	37.6
WP_150348997.1\|3071084_3071564_+	hypothetical protein	NA	NA	NA	NA
WP_150349176.1\|3071635_3071965_+	hypothetical protein	R9TNL4	Vibrio_phage	2.4e-25	55.1
WP_150348998.1\|3071964_3072618_+	hypothetical protein	NA	NA	NA	NA
WP_150348999.1\|3072919_3073246_-	hypothetical protein	NA	NA	NA	NA
WP_150349000.1\|3073405_3074194_+	DNA adenine methylase	Q5ZQW7	Pseudomonas_phage	8.0e-112	73.4
WP_150349001.1\|3074569_3074950_+	HNH endonuclease	H2BDK0	Pseudomonas_virus	5.9e-12	51.2
WP_150349002.1\|3075066_3075549_+\|terminase	phage terminase small subunit P27 family	A4JWZ6	Burkholderia_virus	1.8e-50	61.0
WP_150349003.1\|3075550_3077305_+\|terminase	terminase large subunit	A4JWZ7	Burkholderia_virus	4.0e-252	70.4
WP_150349004.1\|3077301_3078600_+\|portal	phage portal protein	G0ZT36	Aeromonas_phage	2.1e-149	63.1
WP_150349005.1\|3078611_3079481_+\|protease	Clp protease ClpP	K7PH05	Enterobacteria_phage	1.8e-80	61.3
WP_150349006.1\|3079491_3080700_+\|capsid	phage major capsid protein	A0A2H4PI18	Pseudomonas_phage	5.4e-107	53.1
WP_150349007.1\|3080758_3081001_+	hypothetical protein	NA	NA	NA	NA
WP_150349008.1\|3081005_3081335_+\|head,tail	phage gp6-like head-tail connector protein	H2BDB3	Pseudomonas_virus	8.4e-23	61.1
WP_150349177.1\|3081334_3081709_+\|head,tail	head-tail adaptor protein	H2BDB4	Pseudomonas_virus	8.4e-27	49.2
WP_150349009.1\|3081711_3081930_+	hypothetical protein	NA	NA	NA	NA
WP_150349010.1\|3081926_3082412_+	hypothetical protein	NA	NA	NA	NA
WP_150349011.1\|3082411_3082783_+	DUF3168 domain-containing protein	NA	NA	NA	NA
WP_150349012.1\|3082673_3083342_+	hypothetical protein	NA	NA	NA	NA
WP_150349013.1\|3083351_3083684_+	hypothetical protein	NA	NA	NA	NA
WP_150349014.1\|3083722_3084013_+	hypothetical protein	NA	NA	NA	NA
WP_150349015.1\|3084025_3087007_+\|tail	phage tail tape measure protein	A0A2H4J7J3	uncultured_Caudovirales_phage	3.8e-29	32.3
WP_150349016.1\|3087008_3087356_+	hypothetical protein	Q2NPH3	Xanthomonas_virus	1.9e-09	34.4
WP_150349017.1\|3087357_3087834_+	DUF1833 family protein	I7GYA2	Xanthomonas_virus	2.4e-10	25.2
WP_150349018.1\|3087833_3088220_+	hypothetical protein	NA	NA	NA	NA
WP_150349178.1\|3088258_3092053_+	hypothetical protein	A5A3R1	Burkholderia_phage	1.4e-47	25.2
WP_150349019.1\|3092057_3092834_+	hypothetical protein	NA	NA	NA	NA
WP_150349020.1\|3092830_3093220_+	hypothetical protein	NA	NA	NA	NA
WP_150349021.1\|3093285_3093705_+	M15 family metallopeptidase	A9DET4	Yersinia_phage	5.7e-32	54.3
WP_150349179.1\|3093724_3094030_+	chemotaxis protein	A0A059VK40	Pseudomonas_phage	1.2e-07	41.8
3096851:3096901	attR	NA	NA	NA	NA

DBSCAN-SWA_2

4041868 : 4049527

uncultured_Mediterranean_phage(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003811022.1\|4041868_4042753_-	peptidoglycan DD-metalloendopeptidase family protein	A0A292GJG6	Xanthomonas_phage	4.6e-15	49.5
WP_003816528.1\|4042770_4043460_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	3.2e-32	46.9
WP_033459814.1\|4043534_4044293_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.1e-68	51.2
WP_003811015.1\|4044418_4045066_+	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003811013.1\|4045309_4046350_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	9.3e-92	51.6
WP_003811011.1\|4046484_4047777_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.7e-66	36.0
WP_003816534.1\|4047982_4049008_+	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
WP_003811007.1\|4049143_4049527_+	thioredoxin family protein	V9SJ74	Achromobacter_phage	8.1e-09	25.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP044089

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection