CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP044068	Vibrio vulnificus strain FDAARGOS_663 chromosome 1, complete sequence	0 crisprs	DEDDh,cas3,csa3,WYL	0	0	0	0
NZ_CP044069	Vibrio vulnificus strain FDAARGOS_663 chromosome 2, complete sequence	1 crisprs	csa3,RT,cas3,DinG,cas5f,DEDDh,csx1,WYL	1	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP044069_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044069_1

374198-374355

Orphan

Consensus_repeat	Method
TGTATAGCGAGCGCCGTGGCTTGGTTTTATCGCTTCATTACTGGTGTTTCTGTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044069_1

>merge|NZ_CP044069|1|374198-374355|CRISPRCasFinder
TGTATAGCGAGCGCCGTGGCTTGGTTTTATCGCTTCATTACTGGTGTTTCTGTTGATTTAGCTACTCTCTCACCTCGTCATCCTCGCGAACGCGGGGATCCATTGTATAGCGAGCGCCGTGGCTCGGTTTTATCGCTTCATTACTGGTGTTTCTGTTG

>NZ_CP044069|1|1|374198-374355|CRISPRCasFinder
TGTATAGCGAGCGCCGTGGCTTGGTTTTATCGCTTCATTACTGGTGTTTCTGTTG	ATTTAGCTACTCTCTCACCTCGTCATCCTCGCGAACGCGGGGATCCAT
TGTATAGCGAGCGCCGTGGCTCGGTTTTATCGCTTCATTACTGGTGTTTCTGTTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044069.1\|WP_017420708.1\|381516_382386_+\|glucose-1-phosphate-thymidylyltransferase-RfbA	unknown	unknown	gnl\|CDD\|130274
NZ_CP044069.1\|WP_017420722.1\|363842_364136_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044069.1\|WP_017420711.1\|377349_377790_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|319971
NZ_CP044069.1\|WP_011078866.1\|368209_369151_-\|ADP-glyceromanno-heptose-6-epimerase	unknown	unknown	gnl\|CDD\|182998
NZ_CP044069.1\|WP_026050413.1\|375525_376662_+\|polysaccharide-export-protein	unknown	unknown	gnl\|CDD\|237903
NZ_CP044069.1\|WP_013572539.1\|367084_368065_-\|lauroyl-Kdo(2)-lipid-IV(A)-myristoyltransferase	unknown	unknown	gnl\|CDD\|236355
NZ_CP044069.1\|WP_017420721.1\|364286_364766_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NZ_CP044069.1\|WP_017420716.1\|372394_373126_-\|YjbF-family-lipoprotein	unknown	unknown	gnl\|CDD\|378557
NZ_CP044069.1\|WP_017420719.1\|366023_367082_-\|lipopolysaccharide-heptosyltransferase-II	unknown	unknown	gnl\|CDD\|274026
NZ_CP044069.1\|WP_017420718.1\|369348_371598_-\|YjbH-domain-containing-protein	unknown	unknown	gnl\|CDD\|377600
NZ_CP044069.1\|WP_017420715.1\|373158_373362_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044069.1\|WP_017420717.1\|371600_372398_-\|polysaccharide-synthesis-protein	unknown	unknown	gnl\|CDD\|368817
NZ_CP044069.1\|WP_011078857.1\|374635_374896_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044069.1\|WP_017420706.1\|383279_383825_+\|dTDP-4-dehydrorhamnose-3,5-epimerase	unknown	unknown	gnl\|CDD\|376414
NZ_CP044069.1\|WP_017420707.1\|382398_383271_+\|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl\|CDD\|367904
NZ_CP044069.1\|WP_017420709.1\|380356_381418_+\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|236649
NZ_CP044069.1\|WP_017428802.1\|374436_374643_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044069.1\|WP_017420720.1\|364767_366030_-\|3-deoxy-D-manno-octulosonic-acid-transferase	unknown	unknown	gnl\|CDD\|235589
NZ_CP044069.1\|WP_150355167.1\|378012_380193_+\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|183173
NZ_CP044069.1\|WP_017420712.1\|376825_377197_+\|four-helix-bundle-protein	unknown	unknown	gnl\|CDD\|183395

Protein	Function_ID	Function_description	E-value
NZ_CP044069.1\|WP_017420708.1\|381516_382386_+\|glucose-1-phosphate-thymidylyltransferase-RfbA	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	0
NZ_CP044069.1\|WP_011078866.1\|368209_369151_-\|ADP-glyceromanno-heptose-6-epimerase	gnl\|CDD\|182998	PRK11150, rfaD, ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional.	0
NZ_CP044069.1\|WP_017420711.1\|377349_377790_+\|low-molecular-weight-phosphotyrosine-protein-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	4.67675e-65
NZ_CP044069.1\|WP_026050413.1\|375525_376662_+\|polysaccharide-export-protein	gnl\|CDD\|237903	PRK15078, PRK15078, polysaccharide export protein Wza; Provisional.	0
NZ_CP044069.1\|WP_013572539.1\|367084_368065_-\|lauroyl-Kdo(2)-lipid-IV(A)-myristoyltransferase	gnl\|CDD\|236355	PRK08943, PRK08943, lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Validated.	1.7152e-175
NZ_CP044069.1\|WP_017420721.1\|364286_364766_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	8.78869e-28
NZ_CP044069.1\|WP_017420716.1\|372394_373126_-\|YjbF-family-lipoprotein	gnl\|CDD\|378557	pfam11102, YjbF, Group 4 capsule polysaccharide lipoprotein gfcB, YjbF. This family includes lipoprotein GfcB (YmcC), involved in group 4 capsule polysaccharide formation. YjbF is a family of Gram-negative bacterial outer-membrane lipoproteins, predicted to be a beta-barrel and possibly a porin that is one of four gene-products expressed from an operon, yjbEFGH, which is regulated by the Rcs phosphorelay in a RcsA-dependent manner, similar to that of other exopolysaccharide biosynthetic pathways. It is highly possible that the yjbEFGH operon encodes a system involved in EPS secretion since none of the products is predicted to have enzymic activity, the products are all secreted and YbjF and H are predicted to be beta-barrel lipoproteins similar to porins. It may be that the operon products play some role in biofilm formation and/or matrix production.	7.7182e-67
NZ_CP044069.1\|WP_017420718.1\|369348_371598_-\|YjbH-domain-containing-protein	gnl\|CDD\|377600	pfam06082, YjbH, Exopolysaccharide biosynthesis protein YbjH. YjbH is a family of Gram-negative beta-barrel outer-membrane lipoproteins that act as putative porins. YbjH is one of four gene-products expressed from an operon, yjbEFGH, which is regulated by the Rcs phosphorelay in a RcsA-dependent manner, similar to that of other exopolysaccharide biosynthetic pathways. It is highly possible that the yjbEFGH operon encodes a system involved in EPS secretion since none of the products is predicted to have enzymic activity, the products are all secreted and YbjH and F are predicted to be beta-barrel lipoproteins similar to porins. It may be that the operon products play some role in biofilm formation and/or matrix production.	0
NZ_CP044069.1\|WP_017420712.1\|376825_377197_+\|four-helix-bundle-protein	gnl\|CDD\|183395	PRK12275, PRK12275, hypothetical protein; Reviewed.	7.3361e-47
NZ_CP044069.1\|WP_017420717.1\|371600_372398_-\|polysaccharide-synthesis-protein	gnl\|CDD\|368817	pfam06251, Caps_synth_GfcC, Capsule biosynthesis GfcC. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 4 capsule biosynthesis. These proteins have a beta-grasp fold. Two beta-grasp domains, D2 and D3, are arranged in tandem. There is a C-terminal amphipathic helix which packs against D3. A helical hairpin insert in D2 binds to D3 and constrains its position, a conserved arginine residue at the end of this hairpin is essential for structural integrity.	1.96971e-71
NZ_CP044069.1\|WP_017420706.1\|383279_383825_+\|dTDP-4-dehydrorhamnose-3,5-epimerase	gnl\|CDD\|376414	pfam00908, dTDP_sugar_isom, dTDP-4-dehydrorhamnose 3,5-epimerase. This family catalyze the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	7.13071e-108
NZ_CP044069.1\|WP_017420707.1\|382398_383271_+\|dTDP-4-dehydrorhamnose-reductase	gnl\|CDD\|367904	pfam04321, RmlD_sub_bind, RmlD substrate binding domain. L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.	1.64575e-124
NZ_CP044069.1\|WP_017420709.1\|380356_381418_+\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|236649	PRK10084, PRK10084, dTDP-glucose 4,6 dehydratase; Provisional.	0
NZ_CP044069.1\|WP_017420719.1\|366023_367082_-\|lipopolysaccharide-heptosyltransferase-II	gnl\|CDD\|274026	TIGR02195, ADP-heptose--LPS_heptosyltransferase_2, lipopolysaccharide heptosyltransferase II. This family consists of examples of ADP-heptose:LPS heptosyltransferase II, an enzyme of LPS inner core region biosynthesis. LPS, composed of lipid A, a core region, and O antigen, is found in the outer membrane of Gram-negative bacteria. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	2.59515e-172
NZ_CP044069.1\|WP_017420720.1\|364767_366030_-\|3-deoxy-D-manno-octulosonic-acid-transferase	gnl\|CDD\|235589	PRK05749, PRK05749, 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed.	0
NZ_CP044069.1\|WP_150355167.1\|378012_380193_+\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|183173	PRK11519, PRK11519, tyrosine-protein kinase Wzc.	0

>NZ_CP044069.1|WP_017420715.1|373158_373362_-|hypothetical-protein
MDPHVRGDDRVRELMMNPLPLTLATANAKDGFRASKDGYYIEASLDDCLISPFLITPSIVPLNTIFY
>NZ_CP044069.1|WP_017420716.1|372394_373126_-|YjbF-family-lipoprotein
MINLPFQQAILPRFLVRSATVASLILLSGCVQRFDDMSTTLNEAFFGAEDITQTSQQVLELPYASTYMRINDGQRIFMVLGYAEQNPDNSQLQLKWVSSDGGMIVTENGRVVKTLNLPYGNLIRREVDLAHSQQAKPWQANLQWQSQYDWETQSSDSNKGKHYGYLGDVTLTRMGSEEAISAIWQQTLTIWQENIFFPQLDTTVQNQYWVNDSGQVMKSIQYLGPEMTRIEFEILKPFAEAAQ
>NZ_CP044069.1|WP_017420717.1|371600_372398_-|polysaccharide-synthesis-protein
MKNGFSFVTLLSGIVASALTLSPSVLAASQAVDIQQPTQVILLNHGLQLNYPQPVRLEQVLWDAQQQNRQQNDSSNAQALSFHEGFQLFNLNKQAEADTLLQNVRQQLLELAKNEDYRRASQLLLTLVEKHQYGYREDINLDIDAVRLKTDLNPALPGHYALKQASRENQVFLLGLITPKTVPFSADFEVVDYIAGSTLNDNGNKSEAWVISPNGDSSKVGYGYWNNQHVSVQPGSTIFIGFNASNDVLQALESDIVKLLGMIKG
>NZ_CP044069.1|WP_017420718.1|369348_371598_-|YjbH-domain-containing-protein
MTYLNSSSKIPSVGFRSRVSAVCLGVFSALAGVTSLHSHASELETVTLRPSQTDFGGVGLMQMPSGRMAKEGEFNFGVNLNDDYHHYYTSLQLFDWFETTIRYTRVPDMLFNPNPDYSGDNLYTDKGIDFKIRLWQESYWLPETSIGIRDFGGTGLFDGEFIAATKRFGPIDFTLGMGWGYIGQNGNFTNPFCKVSDKFCERPSDYKGSGGSVDFERWFKGPAALYGGIEYQTPYQPLRVKVEYDANDYSQDFPYVRGGKPMPQHTPWNFGVLYQLGDWGDAKLSYQRGDTLTFGFNLYTNFDDLKAVWRDEPKQAVTGRPSEGNTDWQAVAQQLDSNAGYQQSTLYEQGDALVIAGEQVKYRDRKEAQDRAAAILANNAPDYITTYKIVETRNGVDLTQTELDAEAYKQAATYQYLGANSRELGNTSEPDYRENAKPLTTHRERWNAGISPVLAQSLGGPEAFYLFHLGFNTEANYWLTNNIEASGSIYVNLADNYDKFNYVEKDPHISNFAVPRVRTMFRSYVSDNPVRLNHMQLTWFAQPTQQVYTQMYGGYLETMFAGVGGEVLYRPLGKNWALGLDANLISQRDPDSWFATFDEPFVYYDGYDASNCKPNDTGCQAYVLDKGTTGQLSAYYMPQWSLLENTLFKVSAGKFLGGDNGVRVDFSKQFKSGMIVGAFATVTDLTTEEYGEGSYNKGFYISIPFDAMTIKPSTARGVFAWQPITRDGGQTLSRKYELFEVTNARSRWY
>NZ_CP044069.1|WP_011078866.1|368209_369151_-|ADP-glyceromanno-heptose-6-epimerase
MIIVTGGAGMIGSNIVKALNEIGINDILVVDNLKNGRKFKNLVDLDITDYMDRDDFLTQIMAGDNFGPIEAVFHEGACSATTEWDGKYMMLNNYEYSKELLHYCLEREIPFLYASSAATYGETTVFKEEREYEGALNVYGYSKQQFDNYVRRLWQDAEEHGETLSQITGFRYFNVYGPREQHKGSMASVAFHLNNQILAGENPKLFAGSEQFKRDFIYVGDVCKVNLWFMQNGVSGIFNCGTGNAESFEEVAKAVIKHHGKGEIETIPFPEHLKGAYQEFTQADLTKLRAAGCDVEFKTVAEGVAEYMAIVNG
>NZ_CP044069.1|WP_013572539.1|367084_368065_-|lauroyl-Kdo(2)-lipid-IV(A)-myristoyltransferase
MKTERNDFDPKAYHPTFQWGFLAPKYWGTWIAILFAIPITFLPVSIKRRIARTIAKVLIKKRKGTIHNAWVNLHLCFPERSHEEREQILFRCLETAGIYLLTFASLTTRSKKWLTRNTNIKGMEHLQTVLDRKSNVILMVPHTWTIDIPAIVLASRGLPVVGFSKPQKNALTDWLMHRQRVQYGGKIFERDAGVNHFIRAIRKGYLGYYLADQDHGREQRSVFVDFFAATKATLPGVGKLTKVAKAEVVPMVSKLNVDTGQFDVEFFPAWEHFPTENEETDARKMNAHIENVIAESPEQYMWIFQLLRTQEDKTAPNPYRDPRYMD
>NZ_CP044069.1|WP_017420719.1|366023_367082_-|lipopolysaccharide-heptosyltransferase-II
MTKFLIIGPSWVGDMVMSQSLYTTLKQQHPDALIDVIAPGWCKPILERMPEVNRAIEMPLGHGEFNLLGRREIGKSLREFAYDHAYVLPNSAKSALIPWFANIPKRTGWRGEMRYGLLNDLRPNKKAFQYMVERYVALAHPREQMIDSSSLGGLETLPRPKLSIHTDAQQKTLAKFSLAVQSKVIGLCPGAEFGPAKKWPENHYAEVAHAMCQQGHQVWLFGSQKDRDTCNGIKQGVPSEFHHQIHVLAGETSLIEAVDLLAACHTVVSNDSGLMHVAAAVGCNVVAVYGSTSPKYTPPLAENVEIVHTDIECRPCFKRECQYQHLKCLSELTPKHVLDSIRKLDAIAVNAC
>NZ_CP044069.1|WP_017420720.1|364767_366030_-|3-deoxy-D-manno-octulosonic-acid-transferase
MLVRWLYTLLLALAAPLLLFGLYRSKPNKPKFGKRWKEHFGITPTLDGQNQPLWIHAVSVGESLAAVPLIKAIKEKTPDQVIVVTTTTSTGAEQIAKLGNLVEHRYMPIDFAFAVRGFLKAINPAKMLIIETELWPNTLATVHKANIPIIVVNARLSEKSQQNYAKVQPLFNLIHPCLGKVLCQSQADADRFAKLGIPTNKLSVTGSIKFDIHISDEIKHQGAELRTLLGQQRPVWIAASTHRGEDEQVLDAHRQVLETHPNALLILVPRHPERFDSVFELCQTQGFETVRRTQANIIADSTQVYLGDTMGEMLVLLGAADVCFMGGSLVGDKVGGHNVLEPAALGVPVIIGPSYYNFKEVVDTLVTRGGSIITVNISETILKLLVNIQLREELSENAEAFVKQAKGSIKKTISETIKAK
>NZ_CP044069.1|WP_017420721.1|364286_364766_-|glycosyltransferase-family-2-protein
MLTIIIPVYNSEITIKECIESIILADNKNPDLISEVIAIDDGSTDNSFNKLNELASNYEKLTVISQKNTGAGGARNKGIKEAKTKFISFIDSDDLVHEHYLSPLLDNKEKDIISFNILKILKSKKHSIINPKGSPGPMVSAFFNRSIFIKNSLFFFQKA
>NZ_CP044069.1|WP_017420722.1|363842_364136_-|hypothetical-protein
MLYLQEKTKSLKPFDKYQKDLGEIAFNLAYIPAMSLCFRHFSNYTLYVKTKEQLSKLYIVKPKKTPLKKAVFYFCIENLGYLGYLLICIKRLNKIYR
>NZ_CP044069.1|WP_017428802.1|374436_374643_+|hypothetical-protein
MHGNDGWWCDQFSHSVILTNVGIHPSAPAITNVDHNNPSNLLTFTFPKNKKTNTLSSVGLETKALKLS
>NZ_CP044069.1|WP_011078857.1|374635_374896_-|hypothetical-protein
MKKIALAALIALGVSSTAFAAGEAATATTATSTTASTGAAAGAGAGAAGAGAATTAAVAAGAAVAATAVVVSSNNTTGTTGTTGTN
>NZ_CP044069.1|WP_026050413.1|375525_376662_+|polysaccharide-export-protein
MELKTKLLLAMLAPALLAGCTVPGSHLSTDNKNLVEVNDSSQESNLSEVVNLYPLNAQSVTEYAKAQHFTSRANPELDRQIARYEYKVGPGDILNVTIWDHPELTIPAGSYRSASEAGNWVHADGTIFYPYIGTVEVADKTVREIRADIAKRLAKFIESPQVDVNVAAFRSKKAYITGEVENPGQQAITNIPLTVLDAVNRAGGLAEDADWRNVTLTRNGEEQAISLYALMQRGDLTQNRLLEPGDIIHVPRNDSQKVFVMGEVKDPKLLKMDRSGMSLTEALSSVGGINELSADATGVFVIRTSDNKSERMADIYQLNIKDASALVIGTEFDLKPYDIVYVTAAPITRWNRVISQLMPTISGFNELTEGALRVKTWP
>NZ_CP044069.1|WP_017420712.1|376825_377197_+|four-helix-bundle-protein
MRYKELEIWKRSYQVVLQVYSLLKTCRDRGLKDQISRSAVSVPSNIAEGSERGSYKDNIRFLYIAKGSCAELATQISLAVDLGYIPMEAGRKLESEILEIGRMIGGYIKFLSQHVKEESAEYF
>NZ_CP044069.1|WP_017420711.1|377349_377790_+|low-molecular-weight-phosphotyrosine-protein-phosphatase
MFNKILVVCVGNICRSPTGERVLQKLLPNKTVASAGIAAEKSRLIGKPADAMAIEVAKENCVDVENHQSQQLTSALCSQYDLILVMEKGHMEALTQIAPEARGKTMLFGQWIGQKDIPDPYRQSKEAFVHAYQLIDEAAQAWAKKL
>NZ_CP044069.1|WP_150355167.1|378012_380193_+|polysaccharide-biosynthesis-tyrosine-autokinase
MNETMTTPQNRSSVDNSSDEIDLGKLLGILLDAKWIILVTTFFFAVGGVAVALLSTPIYKADALIQIEQKSSGGISSLVGDMGELFSQESSATTEIEIIKSRMILGDTVDKFNLTTVAEPKYLPVIGKGLARIAGKVNQIEISRYTVPEYAQEMKHTLVVLDAEKKTYQLVRGDEQVVLKGVAGELAKNDGYELFVTELRSHNDQEFAIGQRSRLEAIEWLKQNLAISERGKQTGILQLSFEGENRKQIGELLNHISQTYFLQNVERNSAEAEKSLTFLKGHLPDIKTSLTTAEDTLNRFRQDNESIDLGLEAKSTLDVMVKLEAQLNELTFKESEISQRFTKDHPAYRSLLDKRETLLKERERLNQQVQKLPKTQREVLRMTRDVEVNQQIYIQLLNKVQELSIIKAGTVGNVRILDEAQSYAKPVKPKKPLIVVLATLLGGMLSVALVLVKAALHRGVENPDEIEQIGLSVYASVPKSNLQLELANKLARKKRNTDLTLLAESNPADLSIEALRGLRTSLHFAMMEAKNNVLMISGPAPGIGKSFVSTNFAAVAAKTGQKVLLIDADMRKGYLQQCFGLNWENGLSDLLSGKVTRDVAVQSAKVENLDIITRGQVPPNPSELLMHPRFKELVDWASEHYDLVIIETPPVLAVTDPSIVGAIAGTTLMVARFGQNTVKEIDVARSRFEQAGIEVKGVILNAIEKKASSSYGYGYYNYSYGESNKA
>NZ_CP044069.1|WP_017420709.1|380356_381418_+|dTDP-glucose-4,6-dehydratase
MKILVTGGAGFIGSAVVRHIINDTQDSVVNLDKLTYAGNLESLASVAYSDRYAFEQVDICDRAGLERVFAVHQPDAVMHLAAESHVDRSIDGPSAFIETNIVGTYTLLEAARSYWNSLPCERKAAFRFHHISTDEVYGDLEGTDDLFTETTSYAPSSPYSASKASSDHLVRAWLRTYGLPTVVTNCSNNYGPYHFPEKLIPLIILNALEGKALPVYGDGMQIRDWLFVEDHARALYKVVTEGVVGETYNIGGHNEKANIEVVKTICSLLEEMVPNKPQGVVQYQNLITYVKDRPGHDVRYAIDASKIERELGWKPQETFESGIRKTVEWYLNNQEWWSRVLDGSYSRERLGIN
>NZ_CP044069.1|WP_017420708.1|381516_382386_+|glucose-1-phosphate-thymidylyltransferase-RfbA
MKGIILAGGSGTRLYPITRGVSKQLLPVYDKPMIYYPISTLMLAGIRDILIITTPEDNDCFKRLLGDGSDFGINLQYAVQPSPDGLAQAFLIGEEFIGDDAACLVLGDNIFYGQSFGKQLKRACELTSQGVATVFGYQVKDPERFGVVEFDQEMKAVSIEEKPVKPKSNYAVTGLYFYDNRVVEMAKQVKPSARGELEITTLNEMYLNDGSLNVELLGRGFAWLDTGTHESLHEASSFVQTIENVQGLKVACLEEIAWRNGWLTDQELEMIAKPMLKNGYGQYLQSLIK
>NZ_CP044069.1|WP_017420707.1|382398_383271_+|dTDP-4-dehydrorhamnose-reductase
MKVLITGCNGQVGHCLTERLKTQAEVLALDYEGLDITNREAVFNTVAEFKPNYIINAAAHTAVDRAEQEVKLSFAINRDGPSYLAQASNECGAVMLHISTDYVFDGMGDKPYQESDSTRPQGVYGQSKLAGEQAVAEACPKHLILRTAWVFGEHGNNFVKTMLRLAQSCDELSIVGDQFGGPTYAGDIADTLITMVQNIEQGNKLKWGVYHFSGMPYVSWYDFASAIFQAAEQHKMLDKQPLLSSIPTSAYPTPAKRPANSRLDCAKIENQFSIKPSDWQAALNNIQAYK
>NZ_CP044069.1|WP_017420706.1|383279_383825_+|dTDP-4-dehydrorhamnose-3,5-epimerase
MKVIDTNIPDVKIIEPTVFGDERGFFMETWNQKRFEELVTGKPTQFVQDNHSKSKKGILRGLHYQTENTQGKLVRVVSGEVFDVAVDIRKDSPTFGQWVGEYLSAENKRQLWIPEGFAHGFYVTSNEAEFVYKCTDYYNPDSEVSIKWDDETLKIQWPLANMPILSNKDLAAQNFLESELL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP044069_1	1.1\|374253\|48\|NZ_CP044069\|CRISPRCasFinder	374253-374300	48	NZ_CP044069.1	373418-373465	0	1.0

1. spacer 1.1|374253|48|NZ_CP044069|CRISPRCasFinder matches to position: 373418-373465, mismatch: 0, identity: 1.0

atttagctactctctcacctcgtcatcctcgcgaacgcggggatccat	CRISPR spacer
atttagctactctctcacctcgtcatcctcgcgaacgcggggatccat	Protospacer
************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

755622 : 762676

Faustovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_013572350.1\|755622_756837_+	IscS subfamily cysteine desulfurase	A0A1X7C038	Faustovirus	2.2e-31	32.1
WP_011078536.1\|756880_757264_+	Fe-S cluster assembly scaffold IscU	A0A218MKD1	uncultured_virus	2.0e-52	77.4
WP_011149601.1\|757336_757660_+	iron-sulfur cluster assembly protein IscA	A0A2H4N7N5	Lake_Baikal_phage	1.8e-25	52.3
WP_017419976.1\|757720_758236_+	co-chaperone HscB	NA	NA	NA	NA
WP_017419977.1\|758257_760111_+	Fe-S protein assembly chaperone HscA	A0A0N9QXN8	Chrysochromulina_ericina_virus	5.7e-108	40.0
WP_011078532.1\|760122_760461_+	ISC system 2Fe-2S type ferredoxin	NA	NA	NA	NA
WP_011078531.1\|760541_760736_+	Fe-S cluster assembly protein IscX	NA	NA	NA	NA
WP_017419979.1\|760888_762187_+	aminopeptidase PepB	Q6GYZ8	Mycoplasma_phage	1.3e-34	33.1
WP_017419980.1\|762250_762676_+	nucleoside-diphosphate kinase	A0A167REB2	Powai_lake_megavirus	6.6e-20	40.6

DBSCAN-SWA_2

841556 : 848264

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_017420849.1\|841556_842696_+	glutamate 5-kinase	A0A1X9I5D0	Streptococcus_phage	3.7e-65	40.4
WP_080586437.1\|842708_843977_+	glutamate-5-semialdehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	3.0e-100	49.0
WP_011149678.1\|844177_844627_+	transcriptional regulator NrdR	NA	NA	NA	NA
WP_017420851.1\|844646_845753_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2I2L4R9	Orpheovirus	6.5e-43	34.2
WP_017420852.1\|845754_846411_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	8.1e-33	35.5
WP_026050425.1\|846508_847618_+	bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	2.3e-64	40.4
WP_011078424.1\|847793_848264_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	2.2e-32	48.7

DBSCAN-SWA_3

1116644 : 1180057

Bacillus_phage(25.0%)

transposase,integrase,protease

attL 1135790:1135822|attR 1176133:1176165

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_061778578.1\|1116644_1117982_+\|transposase	IS4-like element ISVvu3 family transposase	NA	NA	NA	NA
WP_017420313.1\|1119103_1120171_+	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_017420312.1\|1120170_1123284_+	vibriobactin export RND transporter permease subunit VexH	NA	NA	NA	NA
WP_017420311.1\|1123344_1123926_-	porin family protein	NA	NA	NA	NA
WP_017420310.1\|1124069_1124408_+	DUF1244 domain-containing protein	NA	NA	NA	NA
WP_017420309.1\|1124510_1125596_-	PLP-dependent cysteine synthase family protein	NA	NA	NA	NA
WP_011080950.1\|1125725_1126187_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_017420308.1\|1126517_1129565_+	hypothetical protein	NA	NA	NA	NA
WP_017420307.1\|1129621_1130488_-	acyl-CoA thioesterase II	NA	NA	NA	NA
WP_011080947.1\|1130678_1131104_+	hypothetical protein	NA	NA	NA	NA
WP_017420306.1\|1131170_1131473_-	MGMT family protein	NA	NA	NA	NA
WP_017420305.1\|1131623_1132367_+	hypothetical protein	NA	NA	NA	NA
WP_017420304.1\|1132491_1134465_+	GGDEF domain-containing protein	G3MA91	Bacillus_virus	1.4e-08	29.5
WP_017420303.1\|1134834_1135458_+	endonuclease	NA	NA	NA	NA
WP_017420302.1\|1135460_1137326_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
1135790:1135822	attL	NA	NA	NA	NA
WP_017420301.1\|1137291_1138389_+	AAA family ATPase	NA	NA	NA	NA
WP_017420300.1\|1138392_1138701_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_020480147.1\|1138802_1139339_+	hypothetical protein	NA	NA	NA	NA
WP_017420298.1\|1139341_1140727_+	DEAD/DEAH box helicase family protein	NA	NA	NA	NA
WP_017420297.1\|1140850_1143307_+	DEAD/DEAH box helicase family protein	A0A2I5ARD8	Synechococcus_phage	5.6e-10	24.9
WP_017420296.1\|1143382_1144714_+	multidrug transporter	NA	NA	NA	NA
WP_017420295.1\|1144867_1146358_+	type I restriction-modification system subunit M	J7I0U9	Acinetobacter_phage	8.8e-27	31.6
WP_017420294.1\|1146357_1148103_+	restriction endonuclease subunit S	NA	NA	NA	NA
WP_001290352.1\|1148270_1148981_+	DUF3800 domain-containing protein	Q71TB8	Escherichia_phage	1.5e-72	56.0
WP_000205487.1\|1148977_1149457_+	hypothetical protein	NA	NA	NA	NA
WP_017420293.1\|1149622_1150615_+	membrane protein	NA	NA	NA	NA
WP_017420292.1\|1150833_1152597_+	hypothetical protein	NA	NA	NA	NA
WP_017420291.1\|1152612_1152840_+	hypothetical protein	NA	NA	NA	NA
WP_017420290.1\|1152924_1154136_+	hypothetical protein	NA	NA	NA	NA
WP_017420289.1\|1154138_1155854_+	hypothetical protein	NA	NA	NA	NA
WP_086016732.1\|1155857_1157035_-\|transposase	IS3 family transposase	Q716C2	Shigella_phage	3.9e-118	65.5
WP_017420286.1\|1157094_1157601_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_115173856.1\|1157750_1158161_-	hypothetical protein	NA	NA	NA	NA
WP_017420284.1\|1158560_1160651_+	type I secretion system permease/ATPase	W8CYL7	Bacillus_phage	5.7e-48	29.9
WP_017420283.1\|1160653_1162018_+	HlyD family type I secretion periplasmic adaptor subunit	NA	NA	NA	NA
WP_017420282.1\|1162022_1164131_+	type I secretion system permease/ATPase	W8CYL7	Bacillus_phage	1.7e-52	31.5
WP_017420281.1\|1164342_1164870_+	hypothetical protein	NA	NA	NA	NA
WP_150355168.1\|1164881_1175549_+	hypothetical protein	A0A2H4JEI4	uncultured_Caudovirales_phage	9.8e-19	36.7
WP_017428825.1\|1176385_1177570_+	DUF1611 domain-containing protein	NA	NA	NA	NA
1176133:1176165	attR	NA	NA	NA	NA
WP_026050782.1\|1178003_1179068_+\|protease	FtsH protease activity modulator HflK	NA	NA	NA	NA
WP_017428827.1\|1179064_1180057_+\|protease	protease modulator HflC	NA	NA	NA	NA

DBSCAN-SWA_4

2822853 : 2834003

uncultured_Mediterranean_phage(25.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039470155.1\|2822853_2825436_-\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	1.7e-78	38.1
WP_038964353.1\|2825616_2826078_-	recombination regulator RecX	NA	NA	NA	NA
WP_039470153.1\|2826187_2827237_-	recombinase RecA	A0A2D1GPX2	Mycobacterium_phage	1.8e-111	60.3
WP_017420280.1\|2827369_2827873_-	nicotinamide-nucleotide amidase	B5TK85	Pseudomonas_phage	3.1e-24	43.3
WP_026050395.1\|2827956_2830518_+	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	1.3e-30	22.2
WP_017420278.1\|2830593_2831586_-	RNA polymerase sigma factor RpoS	F4YCU2	Synechococcus_phage	1.5e-35	34.8
WP_049797988.1\|2831666_2832563_-	peptidoglycan DD-metalloendopeptidase family protein	I3PV79	Clostridium_phage	2.0e-13	34.1
WP_017420276.1\|2832606_2833233_-	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.8e-37	52.4
WP_017420275.1\|2833235_2834003_-	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	1.1e-68	51.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage