CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP023701	Streptomyces subrutilus strain ATCC 27467 chromosome, complete genome	10 crisprs	DEDDh,DinG,cas3,WYL,cas4,csa3	0	2	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP023701_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_1

1526590-1526689

Orphan

Consensus_repeat	Method
CCGCGCCGCGGGCCCCGTACCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_1

>merge|NZ_CP023701|1|1526590-1526689|CRISPRCasFinder
CCGCACGGCCGGACGCGGACCCGCGCCGCGGGCCCCGTACCCGGACCGGACGGTGCGCCGCACGGCCGGACCGCGGTCCGCGCCGCGGGCCCCGTACGCC

>NZ_CP023701|1|1|1526590-1526689|CRISPRCasFinder
CCGCACGGCCGGACGCGGACCCG	CGCCGCGGGCCCCGTACCCGGACCGGACGGTGCGCCGCACGGCCGGACCGCGGT
CCGCGCCGCGGGCCCCGTACGCC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150517114.1\|1538084_1538507_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517103.1\|1522024_1522582_+\|toxin-antitoxin-system,-toxin-component	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517102.1\|1521291_1521960_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|376540
NZ_CP023701.1\|WP_150517115.1\|1539064_1539517_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150521769.1\|1537705_1538014_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226728
NZ_CP023701.1\|WP_150517107.1\|1525410_1526364_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|375319
NZ_CP023701.1\|WP_150517099.1\|1515639_1516161_+\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239217
NZ_CP023701.1\|WP_150521767.1\|1526739_1528287_+\|YfcC-family-protein	unknown	unknown	gnl\|CDD\|224207
NZ_CP023701.1\|WP_150517106.1\|1524681_1525254_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP023701.1\|WP_150517101.1\|1518620_1519976_-\|6-phospho-beta-glucosidase	unknown	unknown	gnl\|CDD\|133432
NZ_CP023701.1\|WP_150517100.1\|1516322_1518419_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP023701.1\|WP_150517108.1\|1528384_1530100_-\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|237029
NZ_CP023701.1\|WP_150517110.1\|1535403_1535610_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517105.1\|1523817_1524597_-\|DUF4239-domain-containing-protein	unknown	unknown	gnl\|CDD\|372881
NZ_CP023701.1\|WP_150521768.1\|1532612_1533179_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP023701.1\|WP_150521766.1\|1520088_1520958_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_CP023701.1\|WP_150517104.1\|1522578_1523766_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517111.1\|1535590_1536112_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517112.1\|1536108_1536939_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP023701.1\|WP_150517109.1\|1530377_1532348_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237512

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150521767.1\|1526739_1528287_+\|YfcC-family-protein	gnl\|CDD\|224207	COG1288, COG1288, Predicted membrane protein [Function unknown].	3.32969e-128
NZ_CP023701.1\|WP_150517102.1\|1521291_1521960_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	2.23798e-07
NZ_CP023701.1\|WP_150521769.1\|1537705_1538014_+\|hypothetical-protein	gnl\|CDD\|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.99391e-06
NZ_CP023701.1\|WP_150517107.1\|1525410_1526364_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	5.00916e-62
NZ_CP023701.1\|WP_150517099.1\|1515639_1516161_+\|NUDIX-domain-containing-protein	gnl\|CDD\|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	2.01398e-20
NZ_CP023701.1\|WP_150517109.1\|1530377_1532348_-\|hypothetical-protein	gnl\|CDD\|237512	PRK13800, PRK13800, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	0.000571787
NZ_CP023701.1\|WP_150517106.1\|1524681_1525254_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	4.72805e-08
NZ_CP023701.1\|WP_150517101.1\|1518620_1519976_-\|6-phospho-beta-glucosidase	gnl\|CDD\|133432	cd05296, GH4_P_beta_glucosidase, Glycoside Hydrolases Family 4; Phospho-beta-glucosidase. Some bacteria simultaneously translocate and phosphorylate disaccharides via the phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). After translocation, these phospho-disaccharides may be hydrolyzed by the GH4 glycoside hydrolases such as the phospho-beta-glucosidases. Other organisms (such as archaea and Thermotoga maritima ) lack the PEP-PTS system, but have several enzymes normally associated with the PEP-PTS operon. The 6-phospho-beta-glucosidase from Thermotoga maritima hydrolylzes cellobiose 6-phosphate (6P) into glucose-6P and glucose, in an NAD+ and Mn2+ dependent fashion. The Escherichia coli 6-phospho-beta-glucosidase (also called celF) hydrolyzes a variety of phospho-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, and gentobiose-6P. Phospho-beta-glucosidases are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	0
NZ_CP023701.1\|WP_150517100.1\|1516322_1518419_-\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	5.01436e-76
NZ_CP023701.1\|WP_150517108.1\|1528384_1530100_-\|methionine--tRNA-ligase	gnl\|CDD\|237029	PRK12268, PRK12268, methionyl-tRNA synthetase; Reviewed.	0
NZ_CP023701.1\|WP_150517105.1\|1523817_1524597_-\|DUF4239-domain-containing-protein	gnl\|CDD\|372881	pfam14023, DUF4239, Protein of unknown function (DUF4239). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 254 and 270 amino acids in length.	4.50041e-08
NZ_CP023701.1\|WP_150521768.1\|1532612_1533179_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	1.1056e-11
NZ_CP023701.1\|WP_150521766.1\|1520088_1520958_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.31904e-10
NZ_CP023701.1\|WP_150517112.1\|1536108_1536939_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	8.06703e-08

>NZ_CP023701.1|WP_150517107.1|1525410_1526364_-|helix-turn-helix-domain-containing-protein
MNQSGPKAELGDFLRSRRGRIRPEDAGLRSLGGRRRVPGLRREELARLAGVSVDYYTRFEQGRAGNVSDAVLGAVAVALRLDDAETAHLTRLVRTAGRGAGSVRAAAALDGAREPQEVRAGLRRLLESMPETPAFVVGRRTDILAWNPLFATLVTDFGALPPEHRNKAWLVFLDPEVRGRFVNWERKARDLVAFLRFDLGRHPHDPRFAALIAELGERSPEFNGLWAEQEVRGKTHGGYHLRHPLVGEFTLAYESLNLPDDPDQTLITYTAEAGSPSEAALRILSEASASAAASASSASRPGEGLGPAAGPVRTPPA
>NZ_CP023701.1|WP_150517106.1|1524681_1525254_-|hypothetical-protein
MTAWQYLAGAGLVAALCPLYGHVAVAGDGHGRGARVDLCVPGGPHGHLVVRPPAADPSGRPTVRPTAPGPGRPTVHHPGRTPLPAAPPPSSAPAARPAPAPAPDAGDAKPPEAGPDVAAAVGPTPAPSPAPPRAAPVAARVSAFHMRPYRAVALQRRTPGGLSTVMLMTVVTTPAVLAAAALRPGSRRRG
>NZ_CP023701.1|WP_150517105.1|1523817_1524597_-|DUF4239-domain-containing-protein
MSEWLVLAIAMALVCALVLAITTIRHRRVAADEDTSETPDVIEYMVMMVGVVYAIVLGLAIAGVWEARGSAEDSVRREAQSLYEVTQRADVYPAPVRDRIRGEVDAYVSHTVAVDWPLLVSGEGASPEGAQLLGKLRSDVTHQSPSNELQAQAYQPLLDHIAAADDARHSRTQSDESTLPGVVWFGLLVGGVVTVGLIFTLQIRRSGRELLLAGLFSALIVFLLFMVWSFDAPYGRDGIDSAGPFQDLFPTLSVAAAAR
>NZ_CP023701.1|WP_150517104.1|1522578_1523766_+|hypothetical-protein
MNGQDYYIPAAAMAVALAFKLPALRHSWRDPLLRSVCALVLLAGAVFTFAAPPTIGAVNRWSGIANFSAPLVYCLITAFSASCLVLVVNWRGGPPEKTRRVSRMWITVYAVVVVCLVVLFALGDASVERLRDLDTYYANTPYIREMIALYLAAHCVAAVVMVSLCWRWSLQVRGWLRVGLMIIVAGYVFNLGYDATKITSVVARWTGHDLDFLSTFVAPPLASLGALVSAIGFVVPLVCQRLSDNWQSWTTYRRLGALWQEVQISAPEGTPSVQMSWWSAAELRVIQRESDIHDGFLHLGPYFDRALRDGVHARATADGADEDTARAVADAAMVTAAVRARSEDPEGAVIGSGEETVLDTADGPRDLLRISHALRHAPMVQAVRQQTALPAAGPA
>NZ_CP023701.1|WP_150517103.1|1522024_1522582_+|toxin-antitoxin-system,-toxin-component
MSIGREQRRLCGELVAGIRLTAPVEPVDLYAALCEGMSRHRGRRVDFRMAAFPPGTASGLWLDMADRDLVVIEERTAPDHQLVILGHELWHMKAGHCSHHVDGAAVAARLLSDQADIGETVRRVAARTRADVREETEAETFGLLLGSRCRTWLAGSSSHRAPAQRDQLAGRIEASLGYRGHRNDR
>NZ_CP023701.1|WP_150517102.1|1521291_1521960_+|helix-turn-helix-domain-containing-protein
MTDGFPAPVAVAHAPLAATVTRVAELAGKMGRDLNQVFDLRRLSEASGVPTDVVRTLLDGRPAGEPDLQTRFLQRLDLLRRTRVKSNGRRYTQQEIADGAGMSRQQAGALINGDRRPTMEHCDAIQRFFGVHAGFLTAHDADALTDALQRTEQQLLQDFAGRARETAQAAAASAGDPLARLLQNHGVRGIAWRAAQLPSDKHRDKVTEWLDMLLESVKPNES
>NZ_CP023701.1|WP_150521766.1|1520088_1520958_-|helix-turn-helix-domain-containing-protein
MRQRREELGLSQEDLAARLRISVRAYGNWERGLVKEWTDRKLLALAEALEMSERQCFWLFRVMVDRDPPPTWRAAEENRLPEDPAQRDYLCDYAALMEAVPYPSFLVDHRWDVALTNSAFDRLFQSVRPHPTALPDDNFLRFVLFHPDAAAVLEDHEPAWCVPLLARFATALAAAPEDEGLRSIRQEVARDPFMEAAYRYGVPHWLSTHGAQAAEQDGAVRTVRHPDPRWGLVRCRMVAETSRMLDGMGLTRITLILSAPQGAPTGPAPVGGFPQQRNSRLRAVPSLGE
>NZ_CP023701.1|WP_150517101.1|1518620_1519976_-|6-phospho-beta-glucosidase
MRLTILGGGGFRVPLVYGALLGDHAEGRVTRVVLYDEDAARLGAMARVLADQAAAAGVPDAPAVTATTDLDEALRGADFVFSAIRVGGLEGRAADERVALAEGVLGQETVGAGGIAYGLRTVPVAREIARRIARTAPEAWVINFTNPAGIVTEAMAEELGGRVIGICDSPVGLGRRIARLVGARPQDAWIDYVGLNHLGWVRGLHVGGRDELPRLLADDGALESFEEGRLFGAQWLRSLGAVPNEYLHYYYFNRDTVRAYREAARTRGAFLRDQQRGFYAQAGRPGQPAGAALAAWDRTRAEREATYMAENREVAGVGERDDSDLESGGYEKVALALMRAIARDERATLILNVRNGSTLSVLDAEAVIEVPCLVDANGAHPVGVAPLPLHAVGLVTSVKAVEREVLGAAASGSRATAVKAFALHPLVDSVGVARRLLDGYAAVHPGLAYLR
>NZ_CP023701.1|WP_150517100.1|1516322_1518419_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MRHGAGAVRVRGVTTASVVAAAPPLLDRRRRNVIFGTIMLGVLLAALDQTIVGTALPTIVADLGGAAHMSWVVTSYLLAETVATVLVGKFGDLFGRKVIFQLSAIVFITGSFLCGLAGNMTLLILWRGVQGIGAGGLMVTSMALIADVVPLRERGKYQGAIGAVFGVATVIGPLLGGLFTDHLSWRWAFYVNVPIAVLVVIAAARTIPSVRVAGRPVIDYLGIALVAVGASALILATSWGGNEYAWGSPTIIGLFVGGLVALALFCLVETRAKEPMLPMRLFRNPVFTVCSVLSFVVGFAMLGAMTFLPTYLQYVDGDSATVSGVRTLPLVIGLLIASVFSGTVVSRTGQYRIFPIVGSLVMGVGLYLLSLMGPHTGAWLESLYMFVLGVGIGLSMQVLTIAVQNTVDYADLGTATSGVTFFRTLGSSFGTAVFGTIYANSLEPELKKGVLRAARATGADPVALAAAAQSPKGVHGLDPAAAAPIIDAYAHALQTVFLWTVPVAGFGFVVALFLKQVHLRDSARAGSTDMGDGFGSPATASGDSAKLLELAVGKLVRGMGPDTARGIVEDSDTRLDMAGAWTVMQVDLMTRTVGYASLGLIAGRRSLPPEVLLPVFDRMTEEGFLSRQGSFFTLTPAGQREADVISAAWAAWLGDRLEKDRGRPRSAELRAAADAIAKRLLAEDLGEGNFAPRVAARS
>NZ_CP023701.1|WP_150517099.1|1515639_1516161_+|NUDIX-domain-containing-protein
MSTTPAPDPDRSPVSRPRAVPQPNAVVGVGLVVVDAEGLVLLGQAHDGHWELPGGKVDPGEGFEQAAARELAEETDLRADPADVRVLAVQIGTDPGLTRLTAAAVTTAARGVPLVTEPDKITRWQWFAPDLIPRALYAPSAAVLRVWRPELTALPDVPSHDYATTRPAAPPTG
>NZ_CP023701.1|WP_150521767.1|1526739_1528287_+|YfcC-family-protein
MPPTPPVPPAEPGADPAGAPAPGGRFRLPSALTVLALVTVAVWLLAFLVPAGQYDRDADGSPVSGTYHRVHAPQSLTERLRDLFLSPVNGLYGLRDPVTGEVGPTFAGELYGSAGVFLFVLAIGAFITVVFATGALDRGIARLAHRLRDRGALLITAVMLVFSVLGTVEGFAEETLGFYGLLVPMMLALGYDRLVAVGSAILGAGVGVLCSTVNPFATGVASSAAGISLGDGIVLRFAMWVVLTAVTILYVVRYARRVQRDPAASLCGFLPGDRAQRATGAEVAAPELTGLHRTVLALLALVFGFMVFSVVPWRGALTGRADAAPYAWELGWSFAELSALFLCAAVLVGLVARLGEAKLSSTIVRGAADFTSPALVIMLARGVTVIMNNAKITDTVLHAVEGVVRGTSSGVFAVIVFVVNLPLAFLIPSTSGHATLAMPILAPLADFAGVSRALVVTAWQSASGWMNLWVPTTAVTIGGVALAKVGYDTYLRFVWPLLAILAVLICGFLVLGATV
>NZ_CP023701.1|WP_150517108.1|1528384_1530100_-|methionine--tRNA-ligase
MARHLITSALPYINGIKHLGNMVGSMLPADVYSRYLRQRGHDVLYICATDEHGTPAELAAKEAGVSVAEFCAQAHDAQKAVYDGFRLSFDHFGRSSSAQNAEITQHFARQLQRNGFIEERAIRQVYSPADGRFLPDRYVEGTCPHCGYDKARGDQCENCTRVLDPTDLIEPRSAISGSTDLEVRETTHLFLLQSKLQVEVEAWVAEHEEEWPQLASSIARKWLTEGLHDRAITRDLDWGVPVPADTWPELAAAGKVFYVWFDAPIEYIAATKEWADADPAGRDHKAWWYEAADVRYTQFMAKDNVPFHTVMFPATELGTREPWKKVDYVKAFNWLTYYGGKFSTSQKRGVFTDQALDILPADYWRYFLIANAPESDDSSFTWEHFTATVNKDLADTLGNFVNRVLSFSRKRFGDEVPAGNAAGEAEAKLGGQIAELLAEYENHMETLQYRKAAAALRALWSAGNSYLEEKAPWLEIKTDPEGAALTLRTAMNLIHLYSVVSEPFIPASAAAMRSAFALADDTASWVTPEQARSLDAVPAGTPFTVPPVLFAKITEDDLESYRERFGGSPDA
>NZ_CP023701.1|WP_150517109.1|1530377_1532348_-|hypothetical-protein
MSVSTSQRFGSTAVEQAEAVLVEQYPQLVRLAYVTLPDSFGRHARVLLAHRAVQRALPRGIGRSIGGPGPGGPAPGAVGGPDGPGPLSEVRVRVLRAALAPAGRVRAALARAGWPPVPPFVWGLRLWPPAGGIDEAARVLTGAPGPVRAAFVLHRMDGLPEEAVVRLLGAAGVADPADGVREALALPVDEALPAALRHPEFDASVVSTRPTDLLRRRRRVRAGWGAAAVVALVTGVVLADAPPPRPEVTPAAGPVAAGALDPARLVRVPAEAWADTARVDFTAWPARGARTADRALLARALGTWAARPGGVPVVAAPGTATDPPARPPHLLYAGDSEGRAVVLLLDGDRVVRYAEAADGPRARELAFARTDDAGVTTAAALTVVRNTAGGAARYLLAPWVDRAGTRDLLRAGDGAAPLAVAADGVTAPVAVPPSDGACGSWPVLELTSSARIVEKHAFVLADLGALSPVHLTYTPLPDGPGAVPARQPREVTGPAARAAWVPAACRLRELGGGAVRAVNVWDFADSQLPEGAGRAVWSCTRASGWAGPGDVLVQLRPPAGPSLDVARARSTAACGRFGQHLLAGTRWRSPAGRWYLLAAGSREVAAISAAGAVRAEAAGRSLAAPAAEAGAPVTLTARLASGARITALDGASGGRD
>NZ_CP023701.1|WP_150521768.1|1532612_1533179_+|sigma-70-family-RNA-polymerase-sigma-factor
MGLPSRHRRPTPMSQWGPTARLSYWAFHADRRPAYMRFAYLHLGSDRGAEQAVDAAFDTIMGEWLRMLHMDRLDAYAWTVLKRCIVDRQHPRDPWRHRPEPMDTSAFEAALREARADRYEVLTDTIRFYSAVSRLVERQRDAVLLRYGLRCTPGEAAAVMGVDEATVRSHLGQAHRRLARLLDTSAGS
>NZ_CP023701.1|WP_150517110.1|1535403_1535610_+|hypothetical-protein
MAVTRLVGECEKGTCATLYRVDGTVDLLVQGYDTTDAETAGLDVPAGETVVRIPAEIIERYAREYLAR
>NZ_CP023701.1|WP_150517111.1|1535590_1536112_+|hypothetical-protein
MNISPAEFEKLFSTFRREAFRLETLDDYSGSSDAEMIRAFLAGEPQPDNYNQEWSDEVRENIDAGKRMYRVHIISRPMTDYLRFELGWGYQKNAKAGEEFFILDTTNQPNPLEGVPDFWMFDESSVVSMNYAEGGKFLGAESHISPAEWLERRDVALSRAVPFADWWEQYGEV
>NZ_CP023701.1|WP_150517112.1|1536108_1536939_+|helix-turn-helix-domain-containing-protein
MNGTDLGRALRELRVASGKQAKVVARSAAMSPSKLSKIENGALAPSVLDVERVLTALEISKEMKEQLTEVARQVATEATAWRIYRRIGLYKHQEEIQAIEAQTTLLRVFQPSCIPGLLQTPEYVRGVQQGSELTDDALEKMIGARLRRQEVLYDRSRTFEFLITESAIRWKLIPAPMMAAQMDKLITMSRMSNIRIGIVPLSAAMPGLPTSSFVLFDCRLVIVEIPHAEITTSEMRDIELYVEKFQMFDRVALSGEDMWDLVAGIRDDFLREQETA
>NZ_CP023701.1|WP_150521769.1|1537705_1538014_+|hypothetical-protein
MDQALAFLKVMGDTRAFDMTPSDAVDPGWHSFVLHTQAYAAWCQEQFGFFLGHEPKATVRTRPLIGSVVDRVRAAGFHVDDRLWGAAKEGNPPACCGDGDGC
>NZ_CP023701.1|WP_150517114.1|1538084_1538507_+|hypothetical-protein
MPVDDTLSGQSRVTVFRMFGTVFGYATHSLDDRGIGEVAVVGPLTPGVEWGRLWQMARTMCRPNTGDDEHAHWIMAQANRALTCGSDVVVKFAAATWKLQRGKRANLGGYCHRDHLWTGAMTVEEVTPEQVAAYTPIYTA
>NZ_CP023701.1|WP_150517115.1|1539064_1539517_-|hypothetical-protein
MRRTTLALTVTAALLAATALAALVAVPAAGTWLDSRHQQTSAFDTGAAAKASRASVPRWLPDDARSVRYAMRTTGGERLLKATLPDGAPPAPCTAAPGTAAKAPAIGTDWFPADARDRAAVRCGAYYAYTDGDTLYAWQDNADWIRDGAN

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Crispr_ID: NZ_CP023701_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_2

1823694-1823800

Orphan

Consensus_repeat	Method
CGGCTGCTGGACCCGCTGCGCGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_2

>merge|NZ_CP023701|2|1823694-1823800|CRISPRCasFinder
CGGCTGCTGGACCCGCTGCGCGACTACGACCGGCGCCACCGCGCGGAGCTCATCCCGACCCTGGAGGCCTTCCTGGACTGCGACGGCTCCTGGACCCGCTGCGCGAC

>NZ_CP023701|2|2|1823694-1823800|CRISPRCasFinder
CGGCTGCTGGACCCGCTGCGCGAC	TACGACCGGCGCCACCGCGCGGAGCTCATCCCGACCCTGGAGGCCTTCCTGGACTGCGA
CGGCTCCTGGACCCGCTGCGCGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150517292.1\|1811386_1813603_+\|germacradienol/geosmin-synthase	unknown	unknown	gnl\|CDD\|173835
NZ_CP023701.1\|WP_150521800.1\|1824945_1825686_-\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224715
NZ_CP023701.1\|WP_150517305.1\|1830489_1832040_-\|protein-phosphatase-2C-domain-containing-protein	unknown	unknown	gnl\|CDD\|236090
NZ_CP023701.1\|WP_150517304.1\|1828662_1830405_-\|pyruvate-dehydrogenase	unknown	unknown	gnl\|CDD\|180614
NZ_CP023701.1\|WP_167536918.1\|1827992_1828448_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP023701.1\|WP_150517307.1\|1837202_1837688_+\|DUF456-family-protein	unknown	unknown	gnl\|CDD\|377293
NZ_CP023701.1\|WP_150517300.1\|1824089_1824866_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517301.1\|1825813_1826680_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|378676
NZ_CP023701.1\|WP_150517295.1\|1816296_1817760_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
NZ_CP023701.1\|WP_150517291.1\|1807545_1811157_+\|cobaltochelatase-subunit-CobN	unknown	unknown	gnl\|CDD\|235663
NZ_CP023701.1\|WP_150521801.1\|1836200_1837178_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224296
NZ_CP023701.1\|WP_150521798.1\|1805220_1805853_-\|precorrin-8X-methylmutase	unknown	unknown	gnl\|CDD\|181352
NZ_CP023701.1\|WP_150517296.1\|1818077_1820483_-\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132240
NZ_CP023701.1\|WP_150521799.1\|1805864_1807274_-\|precorrin-3B-synthase	unknown	unknown	gnl\|CDD\|274131
NZ_CP023701.1\|WP_150517306.1\|1832222_1835990_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173812
NZ_CP023701.1\|WP_150517294.1\|1815063_1816215_-\|XdhC-family-protein	unknown	unknown	gnl\|CDD\|224886
NZ_CP023701.1\|WP_150517293.1\|1813688_1814921_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|234945
NZ_CP023701.1\|WP_150517297.1\|1820485_1821094_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP023701.1\|WP_150517302.1\|1826898_1827957_+\|DUF2637-domain-containing-protein	unknown	unknown	gnl\|CDD\|378511
NZ_CP023701.1\|WP_150517298.1\|1821096_1821990_-\|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl\|CDD\|224238

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150517292.1\|1811386_1813603_+\|germacradienol/geosmin-synthase	gnl\|CDD\|173835	cd00687, Terpene_cyclase_nonplant_C1, Non-plant Terpene Cyclases, Class 1. This CD includes terpenoid cyclases such as pentalenene synthase and aristolochene synthase which, using an all-trans pathway, catalyze the ionization of farnesyl diphosphate, followed by the formation of a macrocyclic intermediate by bond formation between C1 with either C10 (aristolochene synthase) or C11 (pentalenene synthase), resulting in production of tricyclic hydrocarbon pentalenene or bicyclic hydrocarbon aristolochene. As with other enzymes with the 'terpenoid synthase fold', they have two conserved metal binding motifs, proposed to coordinate Mg2+ ion-bridged binding of the diphosphate moiety of FPP to the enzymes. Metal-triggered substrate ionization initiates catalysis, and the alpha-barrel active site serves as a template to channel and stabilize the conformations of reactive carbocation intermediates through a complex cyclization cascade. These enzymes function in the monomeric form and are found in fungi, bacteria and Dictyostelium.	1.99749e-80
NZ_CP023701.1\|WP_150517297.1\|1820485_1821094_-\|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	2.18258e-60
NZ_CP023701.1\|WP_150517305.1\|1830489_1832040_-\|protein-phosphatase-2C-domain-containing-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	8.87724e-14
NZ_CP023701.1\|WP_150517304.1\|1828662_1830405_-\|pyruvate-dehydrogenase	gnl\|CDD\|180614	PRK06546, PRK06546, pyruvate dehydrogenase; Provisional.	0
NZ_CP023701.1\|WP_167536918.1\|1827992_1828448_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.96155e-15
NZ_CP023701.1\|WP_150517307.1\|1837202_1837688_+\|DUF456-family-protein	gnl\|CDD\|377293	pfam04306, DUF456, Protein of unknown function (DUF456). This family is a putative membrane protein that contains glycine zipper motifs.	7.51665e-19
NZ_CP023701.1\|WP_150517301.1\|1825813_1826680_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|378676	pfam11575, FhuF_C, FhuF 2Fe-2S C-terminal domain. This family consists of several bacterial ferric iron reductase protein (FhuF) sequences. FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster.	0.000565231
NZ_CP023701.1\|WP_150517295.1\|1816296_1817760_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	9.33851e-110
NZ_CP023701.1\|WP_150517291.1\|1807545_1811157_+\|cobaltochelatase-subunit-CobN	gnl\|CDD\|235663	PRK05989, cobN, cobaltochelatase subunit CobN; Reviewed.	0
NZ_CP023701.1\|WP_150521801.1\|1836200_1837178_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224296	COG1378, COG1378, Predicted transcriptional regulators [Transcription].	2.25088e-09
NZ_CP023701.1\|WP_150521798.1\|1805220_1805853_-\|precorrin-8X-methylmutase	gnl\|CDD\|181352	PRK08285, cobH, precorrin-8X methylmutase; Reviewed.	1.812e-125
NZ_CP023701.1\|WP_150517296.1\|1818077_1820483_-\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|132240	TIGR03196, pucD, xanthine dehydrogenase D subunit. This gene has been characterized in B. subtilis as the molybdopterin binding-subunit of xanthine dehydrogenase (pucD), acting in conjunction with pucC, the FAD-binding subunit and pucE, the FeS-binding subunit. The more common XDH complex (GenProp0640) includes the xdhB gene which is related to pucD. It appears that most of the relatives of pucD outside of this narrow clade are involved in other processes as they are found in unrelated genomic contexts, contain the more common XDH complex and/or do not appear to process purines to allantoin.	0
NZ_CP023701.1\|WP_150521799.1\|1805864_1807274_-\|precorrin-3B-synthase	gnl\|CDD\|274131	TIGR02435, Precorrin-3B_synthase, precorrin-3B synthase. An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	6.40469e-54
NZ_CP023701.1\|WP_150517306.1\|1832222_1835990_-\|S8-family-serine-peptidase	gnl\|CDD\|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	4.54064e-76
NZ_CP023701.1\|WP_150517294.1\|1815063_1816215_-\|XdhC-family-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	3.42834e-53
NZ_CP023701.1\|WP_150517293.1\|1813688_1814921_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|234945	PRK01346, PRK01346, enhanced intracellular survival protein Eis.	5.02399e-108
NZ_CP023701.1\|WP_150521800.1\|1824945_1825686_-\|FCD-domain-containing-protein	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.19322e-32
NZ_CP023701.1\|WP_150517302.1\|1826898_1827957_+\|DUF2637-domain-containing-protein	gnl\|CDD\|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	1.58075e-15
NZ_CP023701.1\|WP_150517298.1\|1821096_1821990_-\|xanthine-dehydrogenase-family-protein-subunit-M	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	3.07374e-59

>NZ_CP023701.1|WP_150517298.1|1821096_1821990_-|xanthine-dehydrogenase-family-protein-subunit-M
MDFLRPASWEEALAAKAEFPTAVPIAGGTDVMVEINFDHRRPEYLLDLNRIGLLREWEVGEDVVRLGASVPYTQIMENLRTELPGLALASHTVASPQIRNRGGVGGNLGCASPAGDSHPALLAAGAEVEVESVRGSRLIPIDEFYTGVKRNALAADELIKTVHVKKADGPQQYSKVGSRNAMVIAVCAFGLALHPQTRTVRTGIGSAAPTPIRAKVAEEFLNSALEEGGFWESGKVITPSIAKQFGDLASGAANPIDDVRGTAKYRRHAVGIMARRQLVWTWEQYRGTTGRSLEGAA
>NZ_CP023701.1|WP_150517297.1|1820485_1821094_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MRVNFTVNGRQQEADDVWEGESLLYVLRERLGLPGSKNACEQGECGSCTVRLDGVPVCSCLVAAGQVEGRDVVTVEGLAEFAKQREEHGHGGACGTGGGCGAKGGVSLDEAKRWQSKPGDSQTGEGVELSTIQQAFIDAGAVQCGFCTPGLLVQADALLEENSSPSDQDIREALSGNLCRCTGYEKILDAVRLAAARQGEAV
>NZ_CP023701.1|WP_150517296.1|1818077_1820483_-|molybdopterin-dependent-oxidoreductase
MAQSTRTVPAGTPTNVTQKHTKGGIGESTLRPDGTLKVTGEFAYSSDMWHEDMLWGQTLRSTVAHAEIVSIDISEALAMPGVYSVLTYDDLPAEMKNYGLEIQDTPVLANGRVRHHGEPVALVAADHPETARRAAAKIKIDYKELPLVTDEASAIAPDAPLIHPGRDDHHAGHVPHPNIVHRQPIVRGNAAEAAKRADVIVTGEYTFGMQDQAFLGPESGLAVPSEDGGVDLYVATQWLHSDLQQIAPVLGLPPEKVRMTLSGVGGAFGGREDISMQIHACLLALATNKPVKIVYNRFESFFGHVHRHPAKLYYEHGATKDGKLTHMKCKIVLDGGAYASASPAVVGNASSLSVGPYVIDDVDIEAIALYSNNPPCGAMRGFGAVQACFAYEAQMDKLAAKLGMDPVEFRQLNAMEMGTIMPTGQVVDSPAPVAELLRRVKARPLPPERQWETAGEGADVRALPGGLSNTTHGEGVVRGVGYAVGIKNVGFSEGFDDYSTARVRLEVINGEPVAMVHTAMAEVGQGGVTVHAQIARTELGVTQVTIHPADTQVGSAGSTSASRQTYMTGGAVKNTCEAVREAVLEIGRRKNGSYHPAWATAELLLEGGKVVTDGGEVLAELADILEGEDAIDLELEFRHRPTVPFDLKTGQGNGHVQYTFAAHRAVVEVDTELGLVKVVELATAQDVGKALNMLSVVGQIQGGTTQGLGVAIMEEIIVDPKTAKVRNPSFTDYLIPTILDTPTIPVDVLELADPNAPYGLRGMGEAPTLSSTPAVLAAIRQATGLELNKTPIRPEALTGTL
>NZ_CP023701.1|WP_150517295.1|1816296_1817760_-|NCS2-family-permease
MTQSSVEPKTSAEEAGDGSLNPAGRSWLDRYFHITHRGSNVGNEVRGGITTFMAMAYILLLNPLLLSGKDVSGAVMDGSAIITATAFAAAVTTLLMGFVGKVPLALAAGLSVSGVLASQVAPQMTWPQAMGMCVVYGVVICLLVVTGLREMIMNAIPLALKHAITMGIGLFVALIGFVKAGFVGNGGEFMPPVQLGATGELSGWPVLLFAITLLAIFMLQARKVPGAILIGIVGGTVLAAILNAVVDIDPKAWKNGPPELSGSAVSMPDFSLFGKVDFGGWGDVGYMTVGMIVFTLVLAGFFDAMATIIGVGTEAKLADDQGRMPGLSKALFIDGAGGAIGGIAGGSGQTVFVESATGVGEGARTGLASVVTGLFFAACLFFTPITQIVPGEVASAALVVIGAMMMQNARHVDWADTSTAIPVFLTVVVMPFTYSITAGVAAGVISYVAIKVAQGKAREIGGFMWALTGIFLVFFALHPIESWLGVG
>NZ_CP023701.1|WP_150517294.1|1815063_1816215_-|XdhC-family-protein
MLDIAEELNRWVEQGRDFAVATVVAVGGSAPRQPGAALAVDGEGTAIGSVSGGCVEGAVYELCRQALDDGETVRERFGYSDDDAFAVGLTCGGIIDILVTPVPVGSAARAVFEAALAAASRGEAAALARIAQGPAELMGRAVLVRAEGAHEGGLGGHPELDRTIAEEARAMLDAGRTGVLEIGADGRLCGEPLQVLVESSVPPPRMIVFGAIDFASALVRIGKFLGYRVTVCDARPVFATKTRFPEADEIVVDWPHRYLEGTDTDGRTVLCVLTHDAKFDVPLLELALRLPVAYVGAMGSRRTHEDRNKRLREVGVTELELARLRSPIGLDLGARSPEETALSIAAEIVANRRGGTGVALTGAHTPIHPDVARTVFGRIGSVA
>NZ_CP023701.1|WP_150517293.1|1813688_1814921_-|GNAT-family-N-acetyltransferase
MVDIREVPEADIDRALELAYLVFHDRPEKDGRERHHALLTRCDRIGAYEGGALVGFMAAHDFRLSVPGADLPCPGLTFVSVAPTHRRRGVLTALMTERLRRTAAARGPLAALWASEAAIYGRFGFGGATTGATIEIDSTRPLALRIDPDPRPLRLLDPAEALAVLGPLHEAARRRRAGRPSRSPERWTGEWLTERDEEDEELGPPRAIVLGDPDGPPAGYVLYRTKGEDGTGPLRTPGLVRVDELEAATPAVAAALWRCVAGLDLTGRVRAWGRPADDPLLHFAADRDQVRVTAQFPALWLRLVDVRAALTARAWAAPAELVLELTDPRIPANAGRHRLKAGPDGAAYEPARAPADLVLDVRELAACYLGGTRAAELVAAGLVAEHTPGAAAALDAALRTGLLPHTADEF
>NZ_CP023701.1|WP_150517292.1|1811386_1813603_+|germacradienol/geosmin-synthase
MTQPFQLPDFYVPYPARLNPHLEDARVHTKRWARDLQMLEGSGVWEEHDLDSHDYALLCAYTHPDCDAEALSLVTDWYVWVFFFDDHFLEMFKRSQDRDGAKAYLDRLAAFMPMDLAEGFPEATNPVEAGLADLWARTVPAMSLDWRERFSLSTRNLLNESMWELANINIGRVANPLEYIEMRRKVGGAPWSAGLIEYVSAEVPARVAHARPLQVLRDAFSDAVHIRNDIFSYEREVADEGELSNAILVLETFLGCTTQEAAEASNDLLTSRLQQFEQTALAELPQLFADRAMDPAEIAAVLAYAKGLQDWQSGGHEWHMVSSRYMNKEAKATAPLTLPFLPSGLGTTALDLGSVFARRSVELRRRSFTHVPFQRTGPSVIPDVYMPHPLALSPHLAHAREESVAWCRRMGMLDPQPGDPGSAIWNEQKLRGFDFAVCSAGIDPDATADALFLNACWLSWGTYGDDYYPVVFGQAGDLAAAKATTARLIAMIPVDHAEQAVPVTAMERGLADLWVRTSAGMSAQARTEFRATLVTMLESWLWEVDNQVHHRIPDPVDYAEMRRNTFGSHLTMYLCRLGHQGRGIPEDIYASGTIRSLENAVADAACMINDIFSYQKEVEVEGEVHNYVLVTQNFFDIGYPEALHICHALMTQRTEEFEHIVATQLPVLYDDWKLGAEARAALDAYVGELQDWHAGILNWHRKIARYRPQDLNGLPDGLSTRVWGADFGMAAARIALPS
>NZ_CP023701.1|WP_150517291.1|1807545_1811157_+|cobaltochelatase-subunit-CobN
MILLLSTSDTDLLSARAAADGPVPYRFANPSRLPLDDLPGLLDGVDLVVVRLLGGLRAWQEGLDLLLAPGQTRPVVVLTGEQAPDAQLMEASTVPIGTAAEAHGYLAHGGPANLAQLACFLSDTVLLTGHGFEPPAAAPTWGPLERTAGTASGPRIAVLYYRAHQMSGNTAFVHALCEAVEAHGAQALPLYVSSLRTPEPELLAALEGVDAVVTTVLAAGGTKPATASAGGDDESWDAGALASLGVPILQALCLTGSRAAWEESDEGLSPLDSATQVAVPEFDGRLITVPFSFKEFDEDGLPAYVADPERAARVAGIAVRHARLRHIDRRDKKVALVLSAYPTKHSRIGNAVGLDTPASAVELLRTLIAGGYDFGPVEEIPGLVSGDGDELIRALIEAGGHDQDWLTEEQLARNPVRIPAADYRRWYEQLPAELREGVERHWGEAPGTMFVDRSANPEGDIVLAALRRGNLLVLIQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWIQASAQDGGFGADAMIHLGKHGNLEWLPGKNAGLSAACAPDAALGDLPLIYPFLVNDPGEGTQAKRRVHATLIDHLVPPMARAESYGDIARLEQHLDEYAQISAMDPAKLPAIRAQIWTLIQAARLDHDLGLQERPDDEGFDDFLLHVDGWLCEVKDAQIRDGLHVLGGAPTGAARVNLVLAILRARQIWGGTTALPGLREALGLDESAATRTAADAVEERARALVQAMEDAHWSPDAVADVAREHSADVAAVLDFAAREVVPRLAGTVDEIAHVVSALDGRFVPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRLAWETGQALAESLLTRYRTDNGEWPASVGLSLWGTSAMRTSGDDVAEALSLLGVRPVWDEASRRVTGIEPIPLAELGRPRIDVTLRISGFFRDAFPHVIGLLDDAVRLAASLDEPAAENFVRAHAQADLAEHGDERRATTRIFGSRPGTYGAGILQLIDSRDWRTDADLAEVYTVWGGYAYGRGLEGRPARTEMETAYKRITVAAKNTDTREHDIADSDDYFQYHGGMVATVRALRGTAPEAYIGDSTRPETVRTRTLVEETSRVFRARVVNPKWIEAMRRHGYKGAFELAATVDYLFGYDATTGVVADWMYDKLTETYVLDPENRAFLEQANPWALHGIAERLLEAESRGMWEKPDPQVLESLRQVYLDTEGDLEGGAE
>NZ_CP023701.1|WP_150521799.1|1805864_1807274_-|precorrin-3B-synthase
MLAAMPQLPSAASRDEPVIRERGDACPGALRLHAADDGYLARVRIPGGLLDGPAALLLAGAADRLGDGHLDLTSRGNVQLRGLGAGCGGELAAVLERAGLLPAPTHERVRNIVASPLTGLDRRGLPDVAPWVPELDRLLCASAAAAGLSGRFLFALDDGRGDVTRLDADVNLAALDAGRALLWTGGAREALLVAAADAPRAALAAAAHFLDAVRDAGTRAWRVSELPAEHALSAAESGSRLAAAGIRAEVVAAPPAGTGLPPEPGTVAGPDAGPGAPVALSVLAPLGRLTTAQWRHLAGLTGRIRLTPWRGIVVVGVPAHEAGAALAGLAGAGLVTAPDDPWRSVTACTGRPGCAKALADVRTDARAVVHAARGPLPVHWSGCERRCGHPRGSAWVDALATGHGTYALSLDGRPLPPRAGLAEALAAARSTPPDPPAPADPAAPADPATPAAPAAPAPAVAVSADAVKK
>NZ_CP023701.1|WP_150521798.1|1805220_1805853_-|precorrin-8X-methylmutase
MFEYEKDGAAIYRQSFATIRAEADLSGLPASVAQVAVRMIHACGMTDLPRDLGYTPDVVLRARAALEAGAPVLCDVQMVASGVTRKRLPAGNDVICTLSDPSVPELAARMGTTRSAAALEVWRDRGLLEGSVIAVGNAPTALFRLLEMIEEGAPRPAAVIGVPVGFIGAAESKDALAAHPSGLDHLIVRGRRGGSAIAAAAVNALASVAE
>NZ_CP023701.1|WP_150517300.1|1824089_1824866_+|hypothetical-protein
MADTAMSGAGSTGGDDPLQRAIWRLRSRGCWTDAAALLTPHLSHAGAAVQRTALLVERCLFTGQGWAEAEDALRIAEAVARDDDERGAAACERGQLAYAATVLGVRDRADEARSALGRAAALLSPGSRSRPLLDFRRGLVAEHLADAPQSARPAYHRAHAGAEAHGDTLLLSFTWRHLAALALRDGEVAEARKGFAESLRIREELGFLIGTAPALAALAEAEPEPEAARLRAEARRLFHLLGGVPTWLAEQLHPAPAA
>NZ_CP023701.1|WP_150521800.1|1824945_1825686_-|FCD-domain-containing-protein
MLLTGRDHCGEEDRVREAARAGDGARTARPSVPAQHTPRKVLRHSVRGQVLDALRAALVEGELAPGEIYSGPALGERFGVSATPVREAMQQLALEGAVECLPNRGFRVLTRTPRDMAELAEVRALLEVPVMLRLARTVPPAAWEALRPAAAAAATAAAEGDAPGYAEADRAFHREVLALAGNGRLVQVAQDLHRRAQWPLPGAPRARRAELVADAAQHTALLAALAAGDLAAAESLVRAHLAAAAG
>NZ_CP023701.1|WP_150517301.1|1825813_1826680_+|(2Fe-2S)-binding-protein
MTVAVLSASPPVTSAPAGSPVAEAYARLAEAYEGLVVTERSAHEPVPRGVGWVGADELAAGGPALEAYLAWDEAQVLRDYGQRGRPDVVAGFGLHRYAWPAVLLITLPWFLHRRVPDLPVDAVAYHRTGGRMSVRVETFACLPDDPAASLPGARVVADGEALRGEVRAAVAGHLGPVLEGFGPRMRRGRRALWGMVTDEVVEGLWYLGGLLGEERRAMTELEALLPGSTAPYTGAAGFRTLPGPDGAPLATRDRASCCFFYTISAQDTCVTCPRTCDADRVARLTATS
>NZ_CP023701.1|WP_150517302.1|1826898_1827957_+|DUF2637-domain-containing-protein
MRLTDISLDWLLPGSLLILGVLAAVAVLARGKRESEKAAADDSWERSEERRRRKEAFYGSASYVLLFCCAAVAAALSFHGLVGFGRQNLNLSGGWEYLVPFGLDGAAMFCSVLAVREASHGDAALGSRMLVWLFAGAAAWFNWVHAPRGMGHDGAPQFFAGMSLSAAVLFDRALKQTRRAALREQGLIPRPLPQIRMVRWLRAPRETFGAWSLMLLEGVRTLDEAVDEVREDKKEKENDRHRRREQHRLDRAHIKALGRQNRAFGRTRAREGDMPGLTPGTGSAPVGAEPAIAEPGQLPVRRRPSLQAVNGTDSLDGTGPRTVDLTAEDDTQTLPRLDSLERKLKDLEQQFG
>NZ_CP023701.1|WP_167536918.1|1827992_1828448_-|ATP-binding-protein
MKAVGEVRRALRELMRHRCRTDTADVAELLITELVTNALVHTDQGAEVSASLAPALLRVEVRDRVAKRPRPYVPTADDGTHGRGLVLVQALADAWGVEVLARGAGKVMWFELHGPPGGPGPYGAARDTAYDTAHGTPYGAALDAACEAGPA
>NZ_CP023701.1|WP_150517304.1|1828662_1830405_-|pyruvate-dehydrogenase
MAKQNVAEQFVDILVRAGVRRMYGVVGDSLNPVVDAIRRTDGIDWIQVRHEETAAFAAGAEAQVTGRLAACAGSCGPGNLHLINGLYDAHRSMAPVLALASHIPSSEIGLGYFQETHPDRLFTECSHYSELISNPRQMPRVLQSAIQHAVGRGGVGVVALPGDIASEPAPEKSVETALVTARPSVRPGEGEIEKLVRLVDEADRVTLFCGSGTAGAHAEVMEFADRVKAPIGHALRGKEWIQYDNPYDVGMSGLLGYGAAYEATHECDLLILLGTDFPYNAFLPDDVKIVQVDIRPEHLGRRSQLDLAVWGDVRETLRALNTRVRAKTDRRFLDRMLKKHADALEGVVKAYTRKVEKHTPIHPEYVASVLDELADEDAVFTVDTGMCNVWAARYLSPNGKRRVIGSFSHGSMANALPQAIGAQFTDRNRQVVSMSGDGGFSMLMGDFLTLVQYDLPVKVVLFNNSSLGMVELEMMVSGLPSYGTTNKNPDFAAIARAAGAYGVRVEKPKQLTAALKDAFRHKGPALVDVVTDPNALSIPPRISADMVTGFALSASKIVLDGGVGRMIQMARSNLRNVPRP
>NZ_CP023701.1|WP_150517305.1|1830489_1832040_-|protein-phosphatase-2C-domain-containing-protein
MVAEALRGPGRGSGPRPGGHAGPPLPLGGGPDDPSDGPSAGTPTPTRHDSPPPPPAAPASGIPEPPPRPSPAPAQQPPRAAAPPPPPPPPAAPAGPQPPPRAPGAAAESAPPPAPPAPPAVAEPSEPPVPRAEGPALPPPVPAVPPAPARRREGLLPGPRQGGSGPGATPAVPPPPATAPATTPAPPPPADPPADPRIGGVTGYALGGVAVPPVSDGPGGGPPRAPVAPPPGARPVVRHLGDRAPTYAAEPGALPRTDPAAVDTLTPDTVLEGARYGTYTLRAASVRGDSARYRGEPRRDHLLTARFGSGDEALVLVVLAGGDRAAPGAAEAAADLCRTVAAAVGRSRERLAADILAGHREALRSGLQRLTDRGHGRLRARAAELGLAEGAYTAGLRGLLLPVDPRCSTRICFGAGAGGLFRLRAGRWQDLEPGAPDGPAGADFRFRASVARPGDVLLLCSGGLAEPMREEASLSAELTARWSAPEPPGLAAFLADTQLRLKGYADDRTTAAVWEA
>NZ_CP023701.1|WP_150517306.1|1832222_1835990_-|S8-family-serine-peptidase
MRPISRTAWGAATAVALAVTAVGPSTAQPSGGAPDTRPVTGSEAAAKRSTAPVTVTLVTGDRIVVSTDAAGRSAATAMPREDGSQPVVQTRQSGEDLYVYPEGALKALASGRVDHELFNVTGLVRQGYDDVHSTKLPLIAVYDASVDVARSAPPAPRGADRSRVLDSIGGVALSADKQQAASFWADVTGTDARARAASGTLRKLWLDGKVRANLERSTKQVNATAAWAAGYDGKGTRVAVLDTGTDLDHPDLKGRVGESKNFTDSDSDADRQGHGTHTISTVGGSGAASGGAKRGVAPGAELLSGKVLNDQGYGLDSWIIAGMEWAVASKADVVSMSLGDPSQTSCDDPMSAAAERLAQNTGTLFVIAAGNSGPGNNTVSSPGCAPSVLTVGAVDRDDTTASFSSRGPAGLDHTLKPEIAAPGVGISAAAAGGRGVYAYQSMSGTSMATPHVAGAAAIVKQRHPDWTARQIKAALVGSANTRVPGDVRETGGGRLDVKAAVDTAVLSAPAVQGGAYNWPQDRSDRTAVEVPYTNTGTRPVTLDLAVEKVTGNDGSAVRSPIARLERRSVTVPAGATVKVPLALDPAAKLERSQYGDVTGRVVATSGTVRVSTPFSLYVEPQTVTLRVKLIDRAGKPAGGPSSLDVIGTDDASGERRFNEGAADQVYRVRPGAYFLSAFVGTPDAGEGAELIDSLTYLGRPQVEVKKDTTVVLDARRAGRLDIAADQPLEARNTTLGFARSWDAAWLHAGTATGGRSIRGYYASVEGRAEDGEFEFGSYWRAGAPVLSELKVAGGPALHPVTASTGSDNLDGRGSAPLVNAGSGTPEEFAAAGAKGAIALVETADGALSEAAQHAKDAGAVAVLAHRAAPGRWIPSTGFGGAPVPVLAVQSGEGRALLDRLAAGRVALSWKGTAKSPYVYSLAFPETGRVQGGHTYRVRDRDLGRVDATYDSMGTPADFIDIAGAYRPIGSAVSFGSIETVAAPGRRTEYYTAGDTSWDQLLSSSFPWGEFMTGAQRTYTKGQRTTARWYDGVTGPVAPRDRTGKETLAAERQGNLIGFAPAMWGDGSHFAQPGSFGDIGGLQLKRDGEVIGESWYPFGAFEVPAERGRYELTQSVQKIGPPARTWQRSTSVRTTWGFTSALDPAAYSQGLPVLFPRYAAPMDGTKTVPAADGQRIGLSVTGHAGYAPGALKSARLSYSYDGETWTDAKVTERGGAWTAVVNHEGASGKPVSLKVELTDANGASVAQTVARAYDVR
>NZ_CP023701.1|WP_150521801.1|1836200_1837178_+|helix-turn-helix-transcriptional-regulator
MLGAIGLDEGQESAYRALVALGAAEVPDLAHRLTLPVPQTERTLRHLERHGLAAQSSARPGRWVAAPPGVALGALLTQQRHELEQAELAAVLLAEEYRAEADEPAVHDLVEVVQGASAVAHRFHQLQLGAAEEVCALVSGRPQVVTGTENEAEERASVRGVDYRVVIEREVLALPRGIREASTALARGERVRVTGQVPTKLVIADRTLAMVPLTSRGAEPAALVVHASGLLESLTGLFEAVWRESLPLLLGTSGAAEESDGGPDATDLEILTLLLAGLTDASVAKHLELGLRTVQRRVKGLMELAGVTTRLQLGWHAYERGWVAR
>NZ_CP023701.1|WP_150517307.1|1837202_1837688_+|DUF456-family-protein
MELPQLLLVGLVLLLGVVGVMIPGVPGTWLVWAGLMWWALHEQSTPAWTLLVAATALLLVVQVVTWLLPPRRLRGAGVTTRMAVCAGAGAVLGFVLVPVVGAVPGFVGGVYLCERLRLGTHGEARASVRAVMRAVGTSVLVELFGCLLVVGAWLGMVVAGT

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Crispr_ID: NZ_CP023701_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_3

2009548-2009630

Orphan

Consensus_repeat	Method
CACAACGGGGTCGGCGACAACGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_3

>merge|NZ_CP023701|3|2009548-2009630|CRISPRCasFinder
CCCCGTGGCGGCGGCCACAACGGGGTCGGCGACAACGGCTTCGGTCAGGACAGGTTCGGTGACGGCAGGTTCGGTGACAACGG

>NZ_CP023701|3|3|2009548-2009630|CRISPRCasFinder
CCCCGTGGCGGCGGCCACAACGG	GGTCGGCGACAACGGCTTCGGTCAGGACAGGTTCGGT
GACGGCAGGTTCGGTGACAACGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150517420.1\|2003093_2004683_-\|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	unknown	unknown	gnl\|CDD\|274962
NZ_CP023701.1\|WP_150517422.1\|2005700_2006624_-\|TIGR03560-family-F420-dependent-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274648
NZ_CP023701.1\|WP_150517423.1\|2006823_2007066_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517429.1\|2013458_2015318_+\|methylmalonyl-CoA-mutase	unknown	unknown	gnl\|CDD\|239649
NZ_CP023701.1\|WP_150517417.1\|1998506_1999733_-\|arginine-deiminase	unknown	unknown	gnl\|CDD\|234949
NZ_CP023701.1\|WP_150517427.1\|2011306_2011867_-\|NADPH-dependent-FMN-reductase	unknown	unknown	gnl\|CDD\|274653
NZ_CP023701.1\|WP_150517430.1\|2015314_2017504_+\|methylmalonyl-CoA-mutase	unknown	unknown	gnl\|CDD\|236508
NZ_CP023701.1\|WP_150517424.1\|2007218_2007704_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150521811.1\|2008287_2009433_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|372634
NZ_CP023701.1\|WP_048477630.1\|2009784_2010180_-\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|377370
NZ_CP023701.1\|WP_150517432.1\|2018562_2019564_-\|asparaginase	unknown	unknown	gnl\|CDD\|199208
NZ_CP023701.1\|WP_150517418.1\|1999802_2000306_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517431.1\|2017516_2018503_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl\|CDD\|236515
NZ_CP023701.1\|WP_150517428.1\|2011963_2012905_-\|TauD/TfdA-family-dioxygenase	unknown	unknown	gnl\|CDD\|225086
NZ_CP023701.1\|WP_150517426.1\|2010338_2011088_+\|DUF2470-domain-containing-protein	unknown	unknown	gnl\|CDD\|378456
NZ_CP023701.1\|WP_150517419.1\|2000475_2003097_-\|polynucleotide-kinase-phosphatase	unknown	unknown	gnl\|CDD\|274963
NZ_CP023701.1\|WP_150517434.1\|2020270_2021602_-\|TRAM-domain-containing-protein	unknown	unknown	gnl\|CDD\|225174
NZ_CP023701.1\|WP_150517425.1\|2007826_2008291_-\|nucleotide-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|212144
NZ_CP023701.1\|WP_150517421.1\|2004721_2005678_-\|homocysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|181899
NZ_CP023701.1\|WP_150517433.1\|2019687_2020137_+\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150517420.1\|2003093_2004683_-\|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	gnl\|CDD\|274962	TIGR04074, Methyltransferase_type_12, 3' terminal RNA ribose 2'-O-methyltransferase Hen1. Members of this protein family are bacterial Hen1, a 3' terminal RNA ribose 2'-O-methyltransferase that acts in bacterial RNA repair. All members of the seed alignment belong to a cassette with the RNA repair enzyme polynucleotide kinase-phosphatase (Pnkp). Chemically similar Hen1 in eukaryotes acts instead on small regulatory RNAs. [Transcription, RNA processing, Protein synthesis, tRNA and rRNA base modification].	0
NZ_CP023701.1\|WP_150517429.1\|2013458_2015318_+\|methylmalonyl-CoA-mutase	gnl\|CDD\|239649	cd03677, MM_CoA_mutase_beta, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta heterodimers. For P. shermanni MCM, it is known that only the alpha subunit binds coenzyme B12 and substrates. The role of the beta subunit is unclear. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The reaction proceeds via radical intermediates beginning with a substrate-induced homolytic cleavage of the Co-C bond of coenzyme B12 to produce cob(II)alamin and the deoxyadenosyl radical. MCM plays an important role in the conversion of propionyl-CoA to succinyl-CoA during the degradation of propionate for the Krebs cycle. Methylobacterium extorquens MCM participates in the glyoxylate regeneration pathway. In M. extorquens, MCM forms a complex with MeaB; MeaB may protect MCM from irreversible inactivation. In some bacteria, MCM is involved in the reverse metabolic reaction, the rearrangement of succinyl-CoA to methylmalonyl-CoA. Examples include P. shermanni MCM during propionic acid fermentation and Streptomyces MCM in polyketide biosynthesis.	3.5742e-179
NZ_CP023701.1\|WP_150517417.1\|1998506_1999733_-\|arginine-deiminase	gnl\|CDD\|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
NZ_CP023701.1\|WP_150517427.1\|2011306_2011867_-\|NADPH-dependent-FMN-reductase	gnl\|CDD\|274653	TIGR03567, FMN_reductase_NADPH, FMN reductase, SsuE family. Members of this protein family use NAD(P)H to reduce FMN and regenerate FMNH2. Members include the homodimeric, NAD(P)H-dependent enzyme SsuE from Escherichia coli, which serves as a partner to an FMNH2-dependent alkanesulfonate monooxygenase. It is induced by sulfate starvation. The NADH-dependent enzyme MsuE from Pseudomonas aeruginosa is outside the scope of this model (see model TIGR03566). [Central intermediary metabolism, Sulfur metabolism].	6.49916e-62
NZ_CP023701.1\|WP_150517430.1\|2015314_2017504_+\|methylmalonyl-CoA-mutase	gnl\|CDD\|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0
NZ_CP023701.1\|WP_150517431.1\|2017516_2018503_+\|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl\|CDD\|236515	PRK09435, PRK09435, methylmalonyl Co-A mutase-associated GTPase MeaB.	0
NZ_CP023701.1\|WP_150517428.1\|2011963_2012905_-\|TauD/TfdA-family-dioxygenase	gnl\|CDD\|225086	COG2175, TauD, Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	2.26214e-86
NZ_CP023701.1\|WP_048477630.1\|2009784_2010180_-\|cell-division-protein-SepF	gnl\|CDD\|377370	pfam04472, SepF, Cell division protein SepF. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation. Mutants are viable but the formation of the septum is much slower and occurs with a very abnormal morphology. This family also includes archaeal related proteins of unknown function.	1.45807e-20
NZ_CP023701.1\|WP_150517432.1\|2018562_2019564_-\|asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	2.78114e-98
NZ_CP023701.1\|WP_150517421.1\|2004721_2005678_-\|homocysteine-S-methyltransferase	gnl\|CDD\|181899	PRK09485, mmuM, homocysteine methyltransferase; Provisional.	7.45278e-129
NZ_CP023701.1\|WP_150521811.1\|2008287_2009433_-\|ATP-binding-protein	gnl\|CDD\|372634	pfam13555, AAA_29, P-loop containing region of AAA domain.	0.000504039
NZ_CP023701.1\|WP_150517426.1\|2010338_2011088_+\|DUF2470-domain-containing-protein	gnl\|CDD\|378456	pfam10615, DUF2470, Protein of unknown function (DUF2470). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	9.83366e-06
NZ_CP023701.1\|WP_150517419.1\|2000475_2003097_-\|polynucleotide-kinase-phosphatase	gnl\|CDD\|274963	TIGR04075, Ser/Thr_phosphatase_family_protein, polynucleotide kinase-phosphatase. Members of this protein family are the bacterial polynucleotide kinase-phosphatase (Pnkp) whose genes occur paired with genes for the 3' terminal RNA ribose 2'-O-methyltransferase Hen1. All members of the seed alignment belong to a cassette with the Hen1. The pair acts in bacterial RNA repair. This enzyme performs end-healing reactions on broken RNA, preparing from the RNA ligase to close the break. The working hypothesis is that the combination of Pnkp (RNA repair) and Hen1 (RNA modification) serves to first repair RNA damage from ribotoxins and then perform a modification that prevents the damage from recurring. [Transcription, RNA processing].	0
NZ_CP023701.1\|WP_150517434.1\|2020270_2021602_-\|TRAM-domain-containing-protein	gnl\|CDD\|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	1.29053e-91
NZ_CP023701.1\|WP_150517425.1\|2007826_2008291_-\|nucleotide-pyrophosphohydrolase	gnl\|CDD\|212144	cd11537, NTP-PPase_RS21-C6_like, Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs. RS21-C6 proteins, highly expressed in all vertebrate genomes and green plants, act as house-cleaning enzymes, removing 5-methyl dCTP (m5dCTP) in order to prevent gene silencing. They show significant sequence similarity to the dimeric 2-deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTP pyrophosphatase or dUTPase) and NTP-PPase MazG proteins. However, unlike typical tandem-domain MazG proteins, RS21-C6 contains a single MazG-like domain and functions as a tetramer (a dimer of dimers) with a typical four-helical bundle. Divalent ions, such as Mg2+, are required for its pyrophosphatase activity. This family also includes a pyrophosphatase from Archaeoglobus fulgidus (Af1178). Although its biological role remains unclear, Af1178 shows significant sequence similarity to the mouse RS21-C6 protein.	2.6432e-43
NZ_CP023701.1\|WP_150517422.1\|2005700_2006624_-\|TIGR03560-family-F420-dependent-LLM-class-oxidoreductase	gnl\|CDD\|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	5.59377e-113
NZ_CP023701.1\|WP_150517433.1\|2019687_2020137_+\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	8.98102e-45

>NZ_CP023701.1|WP_150521811.1|2008287_2009433_-|ATP-binding-protein
MRELIAGARHRPVVTGLRLSAFGVHRSASFPLGPVTLLAGPSGSGKSQVLAAYAALAALGSGATLEEAFPDPAARVPERARPDAQQRRGFRIGCTVDGPAGPVRLDLAVQAEPALRIVGERLSQDGQVLLGTALRDPGRRSVQAAWLTGGAIGVTRAPLPDDRLGTALLPLRVAGSTVGQRQVLAAAEQVVVALRSVFPCDPRPERMRAPVPAGEGLLRGDCANLADVLRRTRHECGTRHALLSEAARTACAGPVAGLEVRAAGDGLLRAVLDRGDGRPATELGRLGSGELRFLALALVLLTGPGVLAMDPAAELLSAQQAMTVLADGLDRDMDRGQSAELLRLALLCCGRGHVRLAAAVGETTAATARGLAGVTVVDLSP
>NZ_CP023701.1|WP_150517425.1|2007826_2008291_-|nucleotide-pyrophosphohydrolase
MNDESDLPHHDHPAPHPDRSGPGGDGPEPRDGRSGPRDEERLYRLQRRLADFAAARDWAPYHTPKNLAVALSVEAAELVEIFQWLTPEQSARVMEQPESAHRVADEVADVLAYLLQFCEVLGVDVLDALAAKIERNELRFPVTDGQGLNRHSSE
>NZ_CP023701.1|WP_150517424.1|2007218_2007704_-|hypothetical-protein
MDAVRLIAAGRHTLAQSGAAWDIVSEAWQAQALAQGIGGYLAVTGPPELRAEARGLGEAGGRGCGVLDRAALRGEGSAPERPPRAAQLAGVSDVRQALLGLQALLGEVGIALVGVACGTDDEALYWQCIESIDAADESSDRVRAILRKMTVRERGSASGVL
>NZ_CP023701.1|WP_150517423.1|2006823_2007066_+|hypothetical-protein
MSHEAVSQTPRTTAQTGQPGHDHTGRACVVPVQGGAPKGLLQQMEELMAALNADLSQLDADLQSSTDRTIESSSPSSPSY
>NZ_CP023701.1|WP_150517422.1|2005700_2006624_-|TIGR03560-family-F420-dependent-LLM-class-oxidoreductase
MDLRIFTEPQQGASYDTLLTVAKATEDLGFDAFFRSDHYLRMGSADGLPGPTDAWITLAGLARETSRIRLGTLMTAGTFRLPGVLAIQVAQVDQMSGGRVELGLGAGWFEEEHKAYGIPFPAERMARLEEQLAVVTGLWATEAGATFDYTGRHYRLENSPALPKPAQAKVPVLIGGHGAKRTPRLAARYADEFNMPFASIADTERQFGRVREAAAEAGRAAGDLVYSNALVVCVGKDDAEVARRAAVIGRDVDELKANGLAGSPAEVVEKIGAYEAVGASRVYLQLLDLDDLDHLELISASVLSQLR
>NZ_CP023701.1|WP_150517421.1|2004721_2005678_-|homocysteine-S-methyltransferase
MTRASGPLAEALGRGAVLLDGGLSNQLAAQGCDLSGDLWTARVLAERPEQVAAAHSAYARAGARVLTTAAYQVGYEAFAARGFDRAATTGLLRRSVRLAARVADAAPHPVWVAASVGPYGAVLADGSEYRGRYGLSVRRLADFHRPRIEALLAEGPDVLALETVPDPDEAEALLLVLAETGAAAWLGYTVADGRTRSGAPLDEAFALAARSPQVVAVGVNCCDPAQVLPALEAAASVTAKPLLAYPNDGSVWDAATATWHPPAAPSPPWPLADWYRAGARLLGGCCRVTPADIARLGGRLPPAGPGAASGPRLGAAGK
>NZ_CP023701.1|WP_150517420.1|2003093_2004683_-|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1
MFLTISTTGSPERPASDLGFLLHKHPGKAQEFSTSHGTAHVFYPEATDLRCTAALLLEVDPVALVRRGRGKGRGGAPDAALAQYVNDRPYAASSLLAVALGAVFRSALAGRCAARPELPEQARPLRIEIPVLPARGGAGLVHRLFGPLGWDLVRAEPLPLDEHFPEWGDSRYVRLVLEGEQKLADALRQLYVLLPVLDDAKHYWISPDEVDKLLRAGEGWLAAHPENGLITARYLARHKRLTKDALERLELVRLAEADGSEVEELDNAVDADRDTEERPVPLALRRREAVLAALRAAGARRVLDLGCGQGQLVQALLGDPAFTEIVGVDVSVRALNLAAGRLRPERMGERQRSRVRLLQGSLAYTDKRLAGYDAAVLSEVIEHVDLPRLPALEYAVFGSARPRTAVVTTPNVEYNVRWASLPAGHVRHGDHRFEWTRDEFRAWAAEVAARYGYGVVFVPVGDEDPEVGPPTQMAVFTRADADADSDATTDSDATTDSGTTDSGTTDSGTTGTRTTGTRTTDTPKEGEAA
>NZ_CP023701.1|WP_150517419.1|2000475_2003097_-|polynucleotide-kinase-phosphatase
MTTAETATPGDTHSDTATATATDAGGPAGRPRVLRVTDLSLVVLIGATGSGKSTFARRHFKPTEVISSDYCRGLVADDENDQSASKDAFDVLHHIAAKRLAAGRLTVVDATSVQADARRGLVQLARDHDVLPVAIVLDLPEAVCAARNAARPERAGLPRAVIRRHRRDLHRSLRGLEREGFRTVHVLRTAEEAERAQVVLEKRYNDLTHLTGPFDIIGDVHGCSSELEALLAKLGYADGTHPEGRTAVFVGDLVDRGPDSPGVLRRVMGMVKSGTALCVPGNHENKLGRHLKGAKVQRTHGLAETVEQLEREPAEFVEEVREFIRGLVSHYMLDGGRLVVCHAGLPEKYHGRTSGRVRSHALYGETTGETDAFGLPVRHPWAEDYRGRATVVYGHTPVPDSTWINNTICLDTGAVFGGRMTALRWPERELVDVPAEKVWYEPAAPLAAATPGGHDGRPLDLADVHGRRIVETRHLGNVTVREENAAAALEVMSRFAVDPRLVPYLPPTMAPTATSREDGHLEHPAEAFARYREDGIAQVVCEEKHMGSRATVLVCKDAAAARERFGVDGPTGSVYTRTGRAFFPDAEVTEEVLARLRSAVTDAGLWEELGTDWLLLDGELLPWSLKSGGLLRHQYAAVGAAARSVLPGAIGALEAAASRGVDTGALLERQRGRSADTAAFTDAYRRYCWSTDGLDGVRFAPFQLLAATGRSLAAVPHDEQLFWLDRLVAADAAAGTGLLRGTARVLVDTGDAESVRAATRWWSELTAAGGEGMVVKPLQAYARDGRGRLVQPGIKVRGREYLRIVYGPEYTRPDHLERLRDRFLGHKRSLALREYALGLEALDRLAAGEPLWRVHEAVFAVLALESEPVDPRL
>NZ_CP023701.1|WP_150517418.1|1999802_2000306_-|hypothetical-protein
MKMTARGSIAVLMTCMAAAGAATPAVADSVPVGVPLDAVETTLGVDTPRVATGVPVPVVGAPDVPRHHRGDMLPTPLLPSVPIGTELGNTLIASPVPNLAGTPETDGEGTLDAPATTLRTRTPGAVVGAPLTMPDGSDFGLPHLTAPKLGLIAPELTGAPSALLGLR
>NZ_CP023701.1|WP_150517417.1|1998506_1999733_-|arginine-deiminase
MGFHVDSETGRLRRVILHRPDLELKRLTPSNKDALLFDDVLWVRRARQEHDGFADVLRDRGVEVHLFGDLLCEALEIPEARHLVLDRVFDEKEYGPLATGHLRAAFDGLTSAALAEALVGGMTKREYLDRHAEPVSVRFHALDLDDFLLGPLPNHLFTRDTSAWIYDGVSINAMRWPARRRETVHFEAIYRHHPLFTSSGAFHYWSQGQADYPSTIEGGDVLVIGNGAVLIGMSERTTPQAVEMLARGLFAAGSATTIVALDMPKRRAFMHLDTVMTMVDADTFTQYAGLGMLRSYTIEPGPGAQELKVTDHAPEHMHRAIAAALGLDAIRVLTATQDVHAAEREQWDDGCNVLAVEPGVVVAYERNVTTNTHLRKQGIEVIEIPGSELGRGRGGPRCMSCPVERDAV
>NZ_CP023701.1|WP_048477630.1|2009784_2010180_-|cell-division-protein-SepF
MSRYDVTDEQWEGLAQVVPLRSRNEWPSRVDHRTIPTAPGASAAEQRRFVVIRVQIFADAREVAEYLIAQIPVLLDLTGADGEVAKRILDFSSGVVFGLGSGMHRVDRNVFLLAPVGTEVEGIAAAAVPRS
>NZ_CP023701.1|WP_150517426.1|2010338_2011088_+|DUF2470-domain-containing-protein
MRMSGASATPAADPAPAAARPTDAERVRSVLAAAHSMTVVVDGLRTEVRHLDDSDVLGRLHLHPAAPAAGNPLAALDDERPSIRLEFTDIAPTPARDRVRARVAVLGRLLTPYAEASSGDSTCMEYGQAILETSEGFSSIDLAELDAACPDPLAPYEAGMLTHLLDDHPDLVTLLLRLVDPLPATGILRALPVALDRYGITLRLEERRGHRDVRLPFPSALDHVEQSGAQIQALFSAARRRSHRNTLPA
>NZ_CP023701.1|WP_150517427.1|2011306_2011867_-|NADPH-dependent-FMN-reductase
MPQLLAITGSPSLNSRTAVVADHVLRRLSHAGFTTAHLSVRELPAADLLSARRGEPEIRRALEAVAEADGLVIATPVYKAAYSGLLKAFLDLLPQDGLAGKTVFPLATGGSLAHVLTIDYALRPVLAALGAGHVTAGRFVLDSSVERGAGPDRLRPEAELDLFQAVDEFAGALRAAHGTAALSAAP
>NZ_CP023701.1|WP_150517428.1|2011963_2012905_-|TauD/TfdA-family-dioxygenase
MATATQTTTTVTRIGGRIGAEIGGVRLGGDLSEGTVAEIRDALLAHKVVFLRDQGHLDEAAHEAFARLLGAPVAHPTVPSADGRYALGIDSEHGARANQWHTDVTFVPAYPAFSILRAVTIPPYGGNTLWANTATAYSHLPEPLRALADGLRAVHSNAYDYAALRPDAPAEALAQYREVFTSTTFLTEHPVVRVHPETGERTLLLGNFVQRISGLTGRDSRILQDLFQAHVESPENTVRWQWRAGDVAIWDNRATQHYGVDDSDDHERTLRRVTVDGDVPVGPDGRPSRLISPETVPAPAFGIPSGASTGPDA
>NZ_CP023701.1|WP_150517429.1|2013458_2015318_+|methylmalonyl-CoA-mutase
MTVLPDDGLSLAAEFPDATHEQWQRLVEGVLRKSGKEVSGGAAEDALSTTLQDGLITRPLYTAPEKAPDTGFPGSAPFVRGGRAEGNAVGGWGVRQRHLGTDPVRVNEAVLADLENGVTSLWLVLGRGGLPVDGLARALEGVYLDLAPVTLDAGAEHADAATAFLELCAARGTAPADVRARLGADPLGHEARTGEALDTAAAVALARTAAEGYPQVRAVTVDALPYHEAGGSAAEELGLSLATGVAYLRALTGGGLSTEAALGQLEFRYAATADQFLTIAKLRAARRLWARVAEASGAPEAGAQRQHVVTSPVMTTRRDPWVNMLRATVACMAAGVGGADAVTVLPFDHALGLPDAFARRIARNTSTILVEESHLARVIDPAGGSYYVERLTDELAHAAWAFFQTVEKAGGQAAALRSGLVAERLAATWAERSRKLAQRREPITGVSEFPLLSEKPVVREPAPPAPSGGLPRVRRDEAYEVLRARSDAHLAATGARPRIFLAALGPAAAHTARATFASNLFQAGGVEPVHDPVSVTAETAAAAYAASGADGTAVLCSSDALYAEQAAAVAAALRAAGATTVFLAGKPGTAEEAVDAYVFAGCDAVAVLSRVLDRMGVTS
>NZ_CP023701.1|WP_150517430.1|2015314_2017504_+|methylmalonyl-CoA-mutase
MSSIPDFSELALDGAGPSAGSEEQWRAAVKESTGTAPADLLWETPEGIGVQPLYTGRDLEGLDFLRTYPGVAPYLRGPYPTMYVNQPWTIRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGIPLDRMSVSMTMNGAVLPVLALYIVAAEEQGVSPDKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDIFSFTSQKMPRYNSISISGYHIQEAGATADLELAYTLADGVEYLRAGQAVGLDVDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWARLVGQFDPKNAKSLSLRTHSQTSGWSLTAQDVFNNVTRTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTCRSIDPWGGSAYVEKLTYDLARRAWQHIQEVEAAGGMAQAIDAGIPKLRVEEAAARTQARIDSGRQPVIGVNKYRVATDEEIDVLKVDNSSVRSRQIAKLRRLREERDEAHTQDTLRALTNAAGSGEGNLLALAVDAARAKATVGEISDALEKVYGRHASQIRTISGVYRMEAGASPSVERTRALVDRFEEAEGRRPRILVAKMGQDGHDRGQKVIATAFADLGFDVDVGPLFQTPAEVARQAVEADVHVVGVSSLAAGHLTLVPALREQLAEEGREDIMIVVGGVIPPADVPTLLEMGATAVFPPGTVIPDAAHDLVTRLAADLGHEL
>NZ_CP023701.1|WP_150517431.1|2017516_2018503_+|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MPPKIDIDAYAKGVLDGKRAYVARAITLVESTRAEHRALAQSLLTELLPHAGRARRIGISGVPGVGKSTFIDAFGTMLTGLGHRVAVLAVDPSSTRTGGSILGDKTRMERLAVDPAAFVRPSPSAGTLGGVAKATRESMIVMEAAGYDVVLVETVGVGQSETTVAGMVDSFLLLSLARTGDQLQGIKKGVLELADVLAVNKADGPHERDAKAAARELSGALRLMHPADAAWTPPVLTCSARESAGLDEVWNRLEQHRTLLEAGGRLAAKRAAQQVEWTWSMVRDALLERLRANPAVRELAPALEAAVRAGTLTPTSAADTILSAFTRP
>NZ_CP023701.1|WP_150517432.1|2018562_2019564_-|asparaginase
MGRIVVISTGGTIASRWQGSGFAADADGSEVVATAPLPEGITVELVDLFSVNSPRLTTAHQLTLLRTVHEVLADPGVDGIVVTHGTDTLEESAFLVDLHHHDERPVVFTGSQLPMGSEDGDGPGNLYDALLTASTARGLGVLIVFAGRVHAARGTVKTQAVALDAFADPSREPLGKVGFGKVVVLRGQQRPESLPLPAMPEVPPRVDMVMHHADGDPVLLNAAVAAGASGIVLVGTGAGNATPEIVDAVRAAVANGVLVALTTRVAAGPVTEIYTHGGAVDLVAAGAVPAGTLRAGQTRIAVLSALLGSADGGRRVGLLRQALGADGAVLVGA
>NZ_CP023701.1|WP_150517433.1|2019687_2020137_+|winged-helix-turn-helix-transcriptional-regulator
MDAIDRDILRELQADGRLSNQELAQRVGLTPSPCMRRVRQLEQDGVIQGYHAVIDPEAVGRGFEVLVSVEVRRDREAVETFEAALQEIPDVIEAYRLFGSPGCLLRIAVADLRAYERLWIEKLTALTGVTEVNSQIIMKRIKEPTGLPV
>NZ_CP023701.1|WP_150517434.1|2020270_2021602_-|TRAM-domain-containing-protein
MTEQIEKQSLVGEEYEVEVGPVAHGGHCIARTAEGRVLFVRHTLPGEKVVAKVTEGDTDSRFLRADAITVLDASKDRVAAPCPYAGPGKCGGCDWQHAKPGAQRRLKGEVVAEQLKRLAGLTPEEAGWDGTVMPAEGDKLPAGEVPQWRTRVQFAIDEDGNAGLRRHRSHDIELIDHCMIAAPGVSELGIEKQDWPQMATVEAIAATGSQDRQVVLTPRPGGRLPLVELDKPVSVLRVEEKDGGVHRVHGRPFVRERADGRTYRVGMGGFWQVHPQAADTLIKAVMQGLMPRKGEMALDLYCGVGIFAGALAERLGETGAVLGIESTKRAVEDARHNLADFPRVRIEQGKVEQILPKTGITECDLVVLDPPRAGAGKQTVRHIAGLSARRIAYVACDPAALARDLGYFKENGYKVRTLRVFDLFPMTHHVECVAILERVVKDA

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Crispr_ID: NZ_CP023701_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_4

2741940-2742019

Orphan

Consensus_repeat	Method
GCGGACAGCGGCTGGGGGTTCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_4

>merge|NZ_CP023701|4|2741940-2742019|CRISPRCasFinder
GCGGACAGCGGCTGGGGGTTCGCCGCGCCCGCTCCGGCCCGCTCCGCGCAGCCGCCGGCGGACAGCGGCTGGGGGGTCGC

>NZ_CP023701|4|4|2741940-2742019|CRISPRCasFinder
GCGGACAGCGGCTGGGGGTTCGC	CGCGCCCGCTCCGGCCCGCTCCGCGCAGCCGCCG
GCGGACAGCGGCTGGGGGGTCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150517942.1\|2740730_2741699_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|181818
NZ_CP023701.1\|WP_150517938.1\|2736135_2736633_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP023701.1\|WP_150517946.1\|2743996_2745289_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225971
NZ_CP023701.1\|WP_150521866.1\|2733649_2735788_+\|carbon-starvation-protein-A	unknown	unknown	gnl\|CDD\|184976
NZ_CP023701.1\|WP_167536930.1\|2747306_2747963_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|131992
NZ_CP023701.1\|WP_150517948.1\|2747004_2747310_-\|mycothiol-system-anti-sigma-R-factor	unknown	unknown	gnl\|CDD\|188261
NZ_CP023701.1\|WP_150521867.1\|2735853_2736042_+\|putative-selenoprotein	unknown	unknown	gnl\|CDD\|377308
NZ_CP023701.1\|WP_150517936.1\|2729900_2730923_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP023701.1\|WP_150517937.1\|2731049_2732333_-\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP023701.1\|WP_150517939.1\|2736973_2739370_+\|ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|274170
NZ_CP023701.1\|WP_150517944.1\|2742137_2742776_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
NZ_CP023701.1\|WP_150517940.1\|2739369_2740386_+\|ribonucleotide-diphosphate-reductase-subunit-beta	unknown	unknown	gnl\|CDD\|153108
NZ_CP023701.1\|WP_150521865.1\|2732626_2733391_+\|UTRA-domain-containing-protein	unknown	unknown	gnl\|CDD\|225099
NZ_CP023701.1\|WP_150517953.1\|2750640_2752038_+\|3-phosphoshikimate-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|235037
NZ_CP023701.1\|WP_150517947.1\|2745285_2746794_-\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP023701.1\|WP_150517951.1\|2749004_2749820_-\|SOS-response-associated-peptidase	unknown	unknown	gnl\|CDD\|376837
NZ_CP023701.1\|WP_150517950.1\|2748284_2748944_-\|hydrolase	unknown	unknown	gnl\|CDD\|226101
NZ_CP023701.1\|WP_150517945.1\|2742857_2743865_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP023701.1\|WP_150517941.1\|2740382_2740649_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150517952.1\|2749873_2750587_+\|M50-family-metallopeptidase	unknown	unknown	gnl\|CDD\|315961

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150517942.1\|2740730_2741699_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	6.81976e-128
NZ_CP023701.1\|WP_150517938.1\|2736135_2736633_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.37573e-11
NZ_CP023701.1\|WP_150517946.1\|2743996_2745289_-\|HD-domain-containing-protein	gnl\|CDD\|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	1.17841e-08
NZ_CP023701.1\|WP_150521866.1\|2733649_2735788_+\|carbon-starvation-protein-A	gnl\|CDD\|184976	PRK15015, PRK15015, carbon starvation protein CstA.	0
NZ_CP023701.1\|WP_167536930.1\|2747306_2747963_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|131992	TIGR02947, putative_RNA_polymerase_sigma_factor, RNA polymerase sigma-70 factor, TIGR02947 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and (with the exception of a paralog in Thermobifida fusca YX) one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria and each gene examined is followed by an anti-sigma factor in an apparent operon.	1.1349e-110
NZ_CP023701.1\|WP_150517937.1\|2731049_2732333_-\|extracellular-solute-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.5527e-89
NZ_CP023701.1\|WP_150517950.1\|2748284_2748944_-\|hydrolase	gnl\|CDD\|226101	COG3571, COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only].	1.94046e-22
NZ_CP023701.1\|WP_150517936.1\|2729900_2730923_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.36538e-70
NZ_CP023701.1\|WP_150521867.1\|2735853_2736042_+\|putative-selenoprotein	gnl\|CDD\|377308	pfam04328, Sel_put, Selenoprotein, putative. This entry includes a group of putative selenoproteins from Proteobacteria, Actinobacteria and Firmicutes. The invariant cysteine at the C-terminus is encoded by a TGA Sec codon in some Epsilonproteobacteria, suggesting a redox activity for the protein.	2.29157e-15
NZ_CP023701.1\|WP_150517939.1\|2736973_2739370_+\|ribonucleoside-diphosphate-reductase-subunit-alpha	gnl\|CDD\|274170	TIGR02506, Ribonucleoside-diphosphate_reductase_large_subunit, ribonucleoside-diphosphate reductase, alpha subunit. This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	0
NZ_CP023701.1\|WP_150517944.1\|2742137_2742776_-\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	1.69999e-64
NZ_CP023701.1\|WP_150517940.1\|2739369_2740386_+\|ribonucleotide-diphosphate-reductase-subunit-beta	gnl\|CDD\|153108	cd01049, RNRR2, Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain. Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.	3.91899e-109
NZ_CP023701.1\|WP_150521865.1\|2732626_2733391_+\|UTRA-domain-containing-protein	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.75887e-75
NZ_CP023701.1\|WP_150517953.1\|2750640_2752038_+\|3-phosphoshikimate-1-carboxyvinyltransferase	gnl\|CDD\|235037	PRK02427, PRK02427, 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional.	3.58005e-161
NZ_CP023701.1\|WP_150517947.1\|2745285_2746794_-\|HD-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	8.69727e-69
NZ_CP023701.1\|WP_150517951.1\|2749004_2749820_-\|SOS-response-associated-peptidase	gnl\|CDD\|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	4.72117e-100
NZ_CP023701.1\|WP_150517948.1\|2747004_2747310_-\|mycothiol-system-anti-sigma-R-factor	gnl\|CDD\|188261	TIGR02949, putative_anti-sigma_factor, anti-sigma factor, TIGR02949 family. This group of anti-sigma factors are associated in an apparent operon with a family of sigma-70 family sigma factors (TIGR02947). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria. [Transcription, Transcription factors].	2.35302e-34
NZ_CP023701.1\|WP_150517945.1\|2742857_2743865_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.3231e-09
NZ_CP023701.1\|WP_150517952.1\|2749873_2750587_+\|M50-family-metallopeptidase	gnl\|CDD\|315961	pfam13398, Peptidase_M50B, Peptidase M50B-like. This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.	1.19152e-63

>NZ_CP023701.1|WP_150517942.1|2740730_2741699_+|helix-turn-helix-domain-containing-protein
MLNNVAVAVANGVAPFELGIFCEVFGVDRSAVGLPVYDFAVCAAEDNPLAVGDGHYGLTLPHGPDRLEEADLICLPADREAPVRDYPAALLASLHRAVDRGARVLSVCSGAFVLGAAGLLDDRRCTTHWMHAPALARRFPRARVDPDVLYVDEGPVVTSAGTASGIDACLHVVRQEQGAEVANTIARRMVVPPHRDGGQAQYIRRPLPRTSCDTVGAVIGWMARHLDGEITVEQLAERAHMSPRTFARRFLQETGTTPYQWVLRQRVLLAQELLEATDETVDAIAGRCGFGNAAALRHHFLRALGTTPNAFRRAFRGPQAVA
>NZ_CP023701.1|WP_150517941.1|2740382_2740649_-|hypothetical-protein
MNTLLNLLTVLALAAPLLAPALYGALRERRIDRQLAAAARGEPAAPGRGPAPAADRSPQRGGARSAARHRGHTAHRAPTSARAGERAA
>NZ_CP023701.1|WP_150517940.1|2739369_2740386_+|ribonucleotide-diphosphate-reductase-subunit-beta
MSSNDTKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLHSDVADLAKLTPSEQHMIGRLVAFFATGDSIVSNNLVLTLYKHVNSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPDDRAAAFDAVEEIPSIREKAQFCFRWMDSVEKIDRLETAADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMNFAFEVVDTVRKEEPELFDDALRQQVTDMLKEAVEAELQFGRDLCGDGLPGMNTESMREYLECVADQRLVRLGFPPVYGSQNPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF
>NZ_CP023701.1|WP_150517939.1|2736973_2739370_+|ribonucleoside-diphosphate-reductase-subunit-alpha
MTIAPSAPRAESVPSTVLTGPGEGPGAAILRTLTELTADLPDTDPGRVAAAALRGRSSVADEAELRGLATEAAAGLISEDPAYSRLAARLLTLAVAEEAAGQGATSFSASVAVGHREGLIADRTAAFVAAHAARLDSLVELALAEGADDRFGFFGLRTLHSRYLLRHPITRQVVETPQFFMLRVACGLAEDDSVRAVEEVASLYRLMSRLDYLPSSPTLFNSGTRHPQMSSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRARGSLIRGTNGHSNGIVPFLKTLDASVAAVNQGGRRKGAAAVYLETWHADIEEFLELRDNTGEDQRRTHNLNLAHWVPDEFMRRVNADAPWSLFSPAEVPELVDLWGEEFDAAYRKAEADGLARKTMPARELYGRMMRTLAQTGQGWMTFKDASNRTANQTAEPGTVVHSSNLCTEIIEVTDDGETAVCNLGSVNLGAFVLTETGDIDWERLDETVRTAVTFLDRVVDINFYPTEQAGRSNARWRPVGLGAMGLQDVFFKLKLPFDSPEAKALSTKLSERIMLAAYEASCDLAEKNGPLPAWEQTRTARGVLHPDHYDVERNWPERWDALRARIAATGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLSGEFLQVNAYLVDELKRLGVWDAQSREALREASGSVQGFGWIPAEVRELYRTAWEIPQRGLIDMAAARTPYLDQSQSLNLFLETPTIGKLSSMYAYAWKQGLKTTYYLRSRPATKIARAAQATTPVALPQAAADADALACSLENPESCEACQ
>NZ_CP023701.1|WP_150517938.1|2736135_2736633_+|GNAT-family-N-acetyltransferase
MDITIRTALPADYAELGEITAGAYLSDGHLDFGDGDPYLHTLRDVAGRAARAEVLVAELGGRLLGGVTFAAPGSPLADIAGPGEAEFRMLAVAREARGQGAGEALVRACLERARAIEGVEAVVLSTQQGMEGAHRIYVRLGFTRTPERDWAPIDDLLLLTYRLNL
>NZ_CP023701.1|WP_150521867.1|2735853_2736042_+|putative-selenoprotein
MRRALARARFYVREFSGEAAYDRYVAHARAHDPDAEVPTRRAFERARTDAREADPREGFRCC
>NZ_CP023701.1|WP_150521866.1|2733649_2735788_+|carbon-starvation-protein-A
MAVWVLVGLVGALGWGVLALSRGEEISAAWLLAAALGSYAIGYRFYARFIAHRVLKVDKTRATPAERLDNGVDFHPTDRRVLFGHHFAAVAGAGPLVGPVLAAQMGYLPGTIWIVAGVIFAGAVQDMVTLFFSTRRDGRSLGQMARDEIGPVGGAAALVAVFAIMIILLAVLALVIVNALAHSPWGVFSIGMTIPIALFMGFYLRVLRPGRVTEVSVIGVALLLLAIVAGGWVAESSLAGTFTLEKETLVVWMVAYGFVASVLPVWMLLAPRDYLSTFMKVGTIALLAVGVVIAMPTLKMPAVTEFATRGDGPVFAGSMFPFVFITIACGALSGFHSLVSSGTTPKMIQKETQVRVIGYGAMLTESFVAIMAMIAACIIEPGLFFAVNSPPGVIGTTVETASQAVTGFGFAISPDALAQAAKDVEEASLLSRTGGAPTFALGMSEIFSAVIGGAGMKAFWYHFAIMFEALFILTTVDAGTRVGRFMLQDTLGNVHKSFKDVSWKPGVWLASAVVVGGWGYFLWVGVKDPLGGINQLFPLFGIANQLLAAVALAVCTTLLVKSGRLKWAWVTGVPLAWDVAVTLTASYQKIFSSDVKVGFFAQRDKYQAGIDAEKVLPPAKSMAEMHTVVTNATVDGVLSVLFAVLIVIVLLDAARTCFKAISAPESVKLSEVPWSESKIVAPAGLIATAEERAELAAAGLDSGGGRAKEPVA
>NZ_CP023701.1|WP_150521865.1|2732626_2733391_+|UTRA-domain-containing-protein
MATEGAITEPEGGAATRTARVPKYYRLKRHLLDMTETLPPGTPVPPERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQPLQLSSYTEDMRAQGLEPTSQLLDIGYVTADDTLAGLLKITTGGRVLRIERLRLASGEPMAIETTHLSAKRFPALRRSLVKYTSLYTALAEVYDVRLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHSLDADGEPVEWVRSVYRGDRYKFVARLKRPAV
>NZ_CP023701.1|WP_150517937.1|2731049_2732333_-|extracellular-solute-binding-protein
MKRKLIAAVSVAGMMVGVAACGNGGDDKGKTDAGGAKEITVWVMDGSAPKAWLDEVNKEFSAKHPGVTVKVEEQKWTGIQEKVTTALSENTPPDVIELGNTQTAGYAVTGGLADLTKDKAKLGADAWQKSMLASAEVDGKLYSAPWYAANRVVIYDKKAFEKAGVTAPKTRDEWVAGLEKLKAADPASQALYLPGQSWYVLAGLIWDEGGDLAVKDGDKWKGGLGTPQAASAIEFYKKLQSFSTAPKDKDEANPQQSTDIIPKGGVASWIGLGWEAGGAEKALKDAGKEADFGYFPIPGKTADKTSTVFLGGSNLAVAERSKNKELAKEWLALAAGKDQMTKYAAETKGALLPNQAGANFAAPAGSFAEAMAKAGLNGKITPVTAGWANVETEPNPIKEFMTKVLNGEDPAKAGADADKEIASRINK
>NZ_CP023701.1|WP_150517936.1|2729900_2730923_-|ABC-transporter-permease-subunit
MTVHSQGAATSAPQDAPPKSAGRPKAPTTAPGSSHPVPPRGGRKSLPSGWLPYLLIGPAILSLAVLLLYPLIKNVILSFQDINKVEFIQRKYPFAGFDNYTELLGDSTFWTVVVRSFAFTLANVALIMALGSLIGILLNRLGKWMRLVLSMALVMAWAMPIVASVQVFQWLFDEQFGVMNWVMRTVGFSGYDRHNWFETGLSTLTIVTILVVWGSIPFVALNMYAGLTTVGGELYEAARMDGANGWQTFWKIVFPNLKPFFLITTFLEVIWVFKAFTQVYAMKKGGPDRASEILPVFAYVEGQSQAHYGLAAAISVLTIVILVIVMSFYFRLILKQEEEQ
>NZ_CP023701.1|WP_150517944.1|2742137_2742776_-|peptide-deformylase
MAQQENEVVEAVANDGYVVDTEDCAERELAHRERGTARPITVVGNPVLHRECKDVTEFGDELARLIDDMFASQKAAEGVGLAANQIGVDAKVFVYDCPDDDGNRHTGVVVNPKLVELPAGTRVLDDSNEGCLSVPTAYASLARPDYAEVTGQDAQGNPIKVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMEEGTPRYETVPNA
>NZ_CP023701.1|WP_150517945.1|2742857_2743865_-|hypothetical-protein
MRIFGKVRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLEPWLSESWFNLALLHKFRHDWEQARSAGLRAVALLDREAGAPDWWNVGIAATALQDWPLARRAWQAYGLKVPGDPHGAGDRSKGGGEPVGMELGSAAVRLSPEGEAEVVWGRRLDPARLEVLSIPLPSSGRRWGEVVLHDGVPHGERVTAAGPSYPVFDEIELWAPSPVPTWVVLLEAATEADRDALEQLASDAGFAAEDWSSSVRLLCRTCSESEMPSDEGDGEHLDPHDHSEPGHPGPLGHRTAGSGSLWVPERECGIAAPPGLVRGLLDGWVADSPGSREWRDLEEVC
>NZ_CP023701.1|WP_150517946.1|2743996_2745289_-|HD-domain-containing-protein
MRSAAAWAVRAGAGLLTAAALGATLWNGVSDPGAALAFGALVAVGELARRDRGTVHRAGAAGRIPAEDRQPAPLGSAGALAYALLGENAGRPTHHGVLQVIAVVVAAALAGAVPHIARGRGPDVDQVASRVLTVAFTAVCFAPLYGSGLLRPGAGRGPYLVLFLLLLLGLTALCDAVLAATLARARTGWPYGPLLRDELRARLGIGSAICATGVVMALGVAVAGLWALPVLSVPLLLTQLSFRRIAAVRTTYRQTITSLARATEIAGCTRPGHARRVADLSRAVGRDLGLSERELTVVEYAALMHDIGQLSLVDPVPDGATAGLPADEARRIAGLGGEVARQTGVPAEVAVVVERQAEPYREQPVAARIVRAVNAYDDLSAGGGHPGGSLAALEQLRLGTGHDYQPEVVESLARVLARGGRDRVVPVAPG
>NZ_CP023701.1|WP_150517947.1|2745285_2746794_-|HD-domain-containing-protein
MRALPPGARGYILCVLLAAAACVAPATLDRGTPWPAVALLAALYLGCELVRLCPLPAGRVPEDVGSFFPVLLAAVFLLPPAAAALVALPGGLAGAVVQRPAGVRRVWHAAQQAVAAWVAGHVHGLLGGPATLGAAGSAVSAGGGAGGPGPVGWGADFPYAMLPAAAAATAFCLVLTALDGGVLATAERRPAATAWRGLPARSLAPHCVHGLAGLMMAVMWRSPYGLPAALLVLLPMYISCWVFAQYHRERAAHRSTIRALVQAVDIKDRYTRGHSERVGQASAMIARELGMGEERLEVVRIAGILHDVGKLGVPTRLLRKDGPLTPEERRVIELHPEYGHEMVRGIGFLGEARSAILHHHERVDGSGYPYGLRGEQIPVLARVVAVADAFDAMTSTRSYSRARPVPTALAELERCAGAQFDPAMVRALTGAVARQGWHPVVTSDEDRQTTGPGAGAVAGPGGAPGTGADGAAGLPAQAREAAAGPPAPAPPGRGRRGPGGGA
>NZ_CP023701.1|WP_150517948.1|2747004_2747310_-|mycothiol-system-anti-sigma-R-factor
MSCGEPHETECAEVLDHLYEFLDHEMPDSDCTKFETHFGECNPCLEKYGLEQAVKKLVKRCCGSDDVPSDLRSKVMGRIELIRSGQAVPDHDVTADNPAGG
>NZ_CP023701.1|WP_167536930.1|2747306_2747963_-|sigma-70-family-RNA-polymerase-sigma-factor
MSEEVGPVAGTDEGHAEETTPERNARFERDALGYLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGESNDRKGSGS
>NZ_CP023701.1|WP_150517950.1|2748284_2748944_-|hydrolase
MTTRTETVDTPPGEARITWHTARGARLVLAVGHGAGGGIEARDLRALAAALPPRGVTVALVEQPWRVAGRKVAAAPKVLDEGWRGLWPALVRPGPPVVAGGRSAGARVACRTAAGLDAAGVLALAFPLHPPGRPEKSRAAELLEAGRPTLVVQGGRDAFGRPGEFPAPGARDPYELVEVAHGDHSFAVPKRADTTQEAALAVITDAVGDWLERLAARTT
>NZ_CP023701.1|WP_150517951.1|2749004_2749820_-|SOS-response-associated-peptidase
MCGRYAASRGAEDLAQVFGVEKWEPEEALAPDWNVAPTKEVLVVLDRPLKDAPDPRPVRQLRVLKWGLVPSWAKDPAGAARMINARSETVHEKPSFRRPFAQRRCIVPADGYYEWVTAHDERQLEVEGKKKRARKQPYFVLPADGSVFAMAGIYEFWRDRTLPDDHPLAWWATCSVITAEAETGPLAAAPQEGPASLADIHPRMPLMLTPDRWDAWLDPARTDPDELRDLLAPPPGGLMRAYPVSTAVSNVRNNGPELLDELAAPEEATLF
>NZ_CP023701.1|WP_150517952.1|2749873_2750587_+|M50-family-metallopeptidase
MDSSTTAGLWDRLTGIQTAPDLWLVVVTGVAALAAVGPRPLWRLSRNAVTIAHEGGHGLLALLTGRRLDGIRLHSDTSGVTVSRGRPTGLGMVLTAAAGYTAPSLLGLGGAALLSAHRITLLLWAATALLLAMLVMIRNAYGALTVVLTGGAFLLVSWLAPAEVQALFAYAVVWFLLLGGVRPVFELQAKRRHGGAPDSDADQLGRLTHVPPVVWLLLFHVVALCSLLGGGRWLLGL
>NZ_CP023701.1|WP_150517953.1|2750640_2752038_+|3-phosphoshikimate-1-carboxyvinyltransferase
MTETPALPALWPAPLAEAAVHATVTVPGSKSVTNRALVLASLAAEPGWVRRPLRSRDSQLMADALRAMGVGIEETVSSASGGDDAGGEAWRIIPAALHGPATVDVGNAGTVMRFLPPVATLAAGDIRFDGDPRSYERPLGQVITALRTLGARIDDDGRGALPLTVQGGGALEGGVVEIDATNSSQFVSALLLSAPRFNQGVEVRHVGTNLPSMPHIRMTVEMLRAAGAQVDTPEAGGEKDVWRVTPGALLGRDMIVEPDLSNAQPFLAAALITGGTVTVRDWPRRTTQPGDALRRIFTEMGGSCELTDAGLVFTGTGKIHGIDVDLGEVGELTPGIAAVAALADSESVLRGVQHLRLHETDRLAALTREINALGGDVTETADGLHIRPRPLHGGTFHTYDDHRMATAGAVIGLAVDGVLIENVATTAKTLPDFPAMWAELLAGDAAVSGAAVTGGSAGPGAGAGA

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Crispr_ID: NZ_CP023701_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_5

3600618-3600723

Orphan

Consensus_repeat	Method
CCCTCCGTCGGACGTACCGGCCCGGAGGTGGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_5

>merge|NZ_CP023701|5|3600618-3600723|CRISPRCasFinder
CCCTCCGTCGGACGTACCGGCCCGGAGGTGGTTGCCCGTTCGGCTTGTGGGGGCACCCCGCCGTGGCTCCGCGTCCCTCCGTCGGACGTACCGGCCCGGAGGTGGT

>NZ_CP023701|5|5|3600618-3600723|CRISPRCasFinder
CCCTCCGTCGGACGTACCGGCCCGGAGGTGGT	TGCCCGTTCGGCTTGTGGGGGCACCCCGCCGTGGCTCCGCGT
CCCTCCGTCGGACGTACCGGCCCGGAGGTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150518611.1\|3594899_3595313_-\|DUF3151-family-protein	unknown	unknown	gnl\|CDD\|378646
NZ_CP023701.1\|WP_150521938.1\|3604261_3604978_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP023701.1\|WP_150518609.1\|3592572_3593820_-\|kynureninase	unknown	unknown	gnl\|CDD\|226363
NZ_CP023701.1\|WP_150518612.1\|3595426_3596230_-\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP023701.1\|WP_150518614.1\|3600994_3602179_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235117
NZ_CP023701.1\|WP_150518617.1\|3605157_3605931_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|235546
NZ_CP023701.1\|WP_150521939.1\|3606033_3606747_-\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|273662
NZ_CP023701.1\|WP_150518610.1\|3593812_3594658_-\|tryptophan-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|188272
NZ_CP023701.1\|WP_150518620.1\|3610135_3610921_-\|aldose-1-epimerase	unknown	unknown	gnl\|CDD\|185698
NZ_CP023701.1\|WP_150518607.1\|3590158_3590995_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
NZ_CP023701.1\|WP_150521937.1\|3596769_3597924_+\|transposase	unknown	unknown	gnl\|CDD\|379252
NZ_CP023701.1\|WP_150518619.1\|3609574_3610114_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
NZ_CP023701.1\|WP_150518605.1\|3588063_3589728_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150518608.1\|3591522_3592401_-\|alpha/beta-hydrolase-fold-domain-containing-protein	unknown	unknown	gnl\|CDD\|223730
NZ_CP023701.1\|WP_150518618.1\|3608228_3609251_-\|class-II-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236406
NZ_CP023701.1\|WP_150518615.1\|3602341_3602983_-\|flavodoxin-family-protein	unknown	unknown	gnl\|CDD\|223728
NZ_CP023701.1\|WP_150518606.1\|3589946_3590162_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP023701.1\|WP_150521940.1\|3607160_3608138_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367638
NZ_CP023701.1\|WP_150518613.1\|3597948_3600006_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|379258
NZ_CP023701.1\|WP_150518616.1\|3603247_3604033_-\|AfsR/SARP-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|276938

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150518611.1\|3594899_3595313_-\|DUF3151-family-protein	gnl\|CDD\|378646	pfam11349, DUF3151, Protein of unknown function (DUF3151). This family of proteins with unknown function appears to be restricted to Actinobacteria.	6.29883e-68
NZ_CP023701.1\|WP_150521938.1\|3604261_3604978_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.40397e-13
NZ_CP023701.1\|WP_150518609.1\|3592572_3593820_-\|kynureninase	gnl\|CDD\|226363	COG3844, COG3844, Kynureninase [Amino acid transport and metabolism].	6.37254e-144
NZ_CP023701.1\|WP_150518612.1\|3595426_3596230_-\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	3.74136e-98
NZ_CP023701.1\|WP_150518614.1\|3600994_3602179_-\|hypothetical-protein	gnl\|CDD\|235117	PRK03343, PRK03343, transaldolase; Validated.	4.13089e-36
NZ_CP023701.1\|WP_150521939.1\|3606033_3606747_-\|HAD-family-phosphatase	gnl\|CDD\|273662	TIGR01509, HAD-SF-IA-v3, haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. This model represents part of one structural subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The superfamily is defined by the presence of three short catalytic motifs. The subfamilies are defined based on the location and the observed or predicted fold of a so-called "capping domain", or the absence of such a domain. Subfamily I consists of sequences in which the capping domain is found in between the first and second catalytic motifs. Subfamily II consists of sequences in which the capping domain is found between the second and third motifs. Subfamily III sequences have no capping domain in either of these positions. The Subfamily IA and IB capping domains are predicted by PSI-PRED to consist of an alpha helical bundle. Subfamily I encompasses such a wide region of sequence space (the sequences are highly divergent) that representing it with a single model is impossible, resulting in an overly broad description which allows in many unrelated sequences. Subfamily IA and IB are separated based on an aparrent phylogenetic bifurcation. Subfamily IA is still too broad to model, but cannot be further subdivided into large chunks based on phylogenetic trees. Of the three motifs defining the HAD superfamily, the third has three variant forms: (1) hhhhsDxxx(x)D, (2) hhhhssxxx(x)D and (3) hhhhDDxxx(x)s where _s_ refers to a small amino acid and _h_ to a hydrophobic one. All three of these variants are found in subfamily IA. Individual models were made based on seeds exhibiting only one of the variants each. Variant 3 (this model) is found in the enzymes beta-phosphoglucomutase (TIGR01990) and deoxyglucose-6-phosphatase, while many other enzymes of subfamily IA exhibit this variant as well as variant 1 (TIGR01549). These three variant models were created with the knowledge that there will be overlap among them - this is by design and serves the purpose of eliminating the overlap with models of more distantly related HAD subfamilies caused by an overly broad single model. [Unknown function, Enzymes of unknown specificity].	7.05096e-06
NZ_CP023701.1\|WP_150518610.1\|3593812_3594658_-\|tryptophan-2,3-dioxygenase	gnl\|CDD\|188272	TIGR03036, trp_2_3_diox, tryptophan 2,3-dioxygenase. Members of this family are tryptophan 2,3-dioxygenase, as confirmed by several experimental characterizations, and by conserved operon structure for many of the other members. This enzyme represents the first of a two-step degradation to L-kynurenine, and a three-step pathway (via kynurenine) to anthranilate plus alanine. [Energy metabolism, Amino acids and amines].	3.55185e-148
NZ_CP023701.1\|WP_150518620.1\|3610135_3610921_-\|aldose-1-epimerase	gnl\|CDD\|185698	cd09021, Aldose_epim_Ec_YphB, aldose 1-epimerase, similar to Escherichia coli YphB. Proteins similar to Escherichia coli YphB are uncharacterized members of the aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	7.78309e-57
NZ_CP023701.1\|WP_150518607.1\|3590158_3590995_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	0.000151883
NZ_CP023701.1\|WP_150521937.1\|3596769_3597924_+\|transposase	gnl\|CDD\|379252	pfam13546, DDE_5, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.02941e-21
NZ_CP023701.1\|WP_150518619.1\|3609574_3610114_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	4.23309e-61
NZ_CP023701.1\|WP_150518617.1\|3605157_3605931_-\|glucose-1-dehydrogenase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	8.9602e-80
NZ_CP023701.1\|WP_150518608.1\|3591522_3592401_-\|alpha/beta-hydrolase-fold-domain-containing-protein	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	1.31549e-16
NZ_CP023701.1\|WP_150518618.1\|3608228_3609251_-\|class-II-fructose-bisphosphate-aldolase	gnl\|CDD\|236406	PRK09197, PRK09197, fructose-bisphosphate aldolase; Provisional.	0
NZ_CP023701.1\|WP_150518615.1\|3602341_3602983_-\|flavodoxin-family-protein	gnl\|CDD\|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	1.32833e-11
NZ_CP023701.1\|WP_150518606.1\|3589946_3590162_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	5.11946e-16
NZ_CP023701.1\|WP_150521940.1\|3607160_3608138_+\|hypothetical-protein	gnl\|CDD\|367638	pfam03756, AfsA, A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.	1.27525e-23
NZ_CP023701.1\|WP_150518613.1\|3597948_3600006_-\|GAF-domain-containing-protein	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	5.42524e-15
NZ_CP023701.1\|WP_150518616.1\|3603247_3604033_-\|AfsR/SARP-family-transcriptional-regulator	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	2.15976e-27

>NZ_CP023701.1|WP_150518613.1|3597948_3600006_-|GAF-domain-containing-protein
MDRDNGTAPTGSGTTPTPAPTPAGTTPAPATTSTAPTAPTAPTAPTALAVLELLAQEAPEARFDALLHEARRAGADGAGLTDLNRALELARSVRAGAGRRQQREAALAALVDTAQDLTSPYDLDGLLRVITRRARRLLTFDMAWVSLDRPDGTAYVRTSDGGTTALDPDLDLGAGNGLGGPAGARHAPVWTADHPADAGVPHGPGIDALARAEGLRAIIAVPLRHGDSTLGALYGADRGARRFTPDEIGLLLSLADLAAVAIEKARLLERTRAEVGELERFGSRTNTALTRVRYLWECHARLAGLVLDGASLSTVARATADALDGVLQVRDPGGRPLISTGPLPAAAPDEEDVARAALAVHTDRRPVELPGDVWLAPVLAGAEDLGVLVLHASAPLTAEDVRLLQMAAQSVASLILIQRGTAAAEGPVHEELLRELLDRPNRSDRHLLERTRRLGIELDRPHVVVVARPEGGELGKAVAWASSYAYRMNGLKGVRRGCIVLVLPGSDASAAARQVSAELSPMLGHPVSTGAAGPTGGAREVARVYAEAVRCLDALTALDGAGGTASLGELGFLGLLLSTDHDVEAFVESTIGPVLRYDATRFTELTRTLEAYFDSGASPTHAAEALHVHANTVSRRLDRIAELLGPLWQKPDRALEIQMALRLRKASAVLHDRRAEAARRGTGPQ
>NZ_CP023701.1|WP_150521937.1|3596769_3597924_+|transposase
MTELTEDLCSTVFASLRRRDQREKGLQYVRGLLTTSGRKSIRSIAAHVGGPAAEQSLHHFISSSTWDWQPIRTALTRYLEASDPLGAWVAQPMAIPKGGEHSVGAGHHFDPHRGQMFRGQQAFGTWFTSAGLATPVGWRLFLPDAQGPAEAAANSAPRAAGSPGGPGTGGPAQALSYEECAASGVIETVRGSGLPTRPVVLDIRDIGTRPTMNRFAEARLPVIARISPTSRLLVTDPALPGYGAGARQAVDVLQSVKGLRMPVEWRDPAGPPTHRSTPAVAVRVMMPDPSPARRRHLMLIGEWSDPRGLPSQLWITDLTRLPVGPLLRMTKQARRVAHSSHHVGGELGLRDYAGRSLHGWHRHVTLASVAHAAHSLLARDLPRH
>NZ_CP023701.1|WP_150518612.1|3595426_3596230_-|indole-3-glycerol-phosphate-synthase-TrpC
MSAGRTLDAILDGVRADLTVRQLRVPLGDLKSLAAVGSPPIDAVAALRRPGGVQVIAEVKRASPAAGPLAEITDPGLLAAEYAAGGAAVVSVLTEERRFRGSLADLDAVRARVTVPVLRKDFVVSPYQLWETRAHQADLALLVVAALSQPDLVMLVRLAEDIGLTPLVEVHSEDEVSRAVAAGARLIVVGARDPHTLEVDHRTFAKLAGAIPDDVVRIAQSGIRVPQDVASYAADGADAVLLGEALVTSPTPRHTLTTLLSAGRRPR
>NZ_CP023701.1|WP_150518611.1|3594899_3595313_-|DUF3151-family-protein
MSIHQNLLGGPAPTHLPDEPGREALAAGAPAVEVAAEHPTSSLAWAVLADDAFAAGRTVESYAYARTGYHRGLDALRRAGWKGHGPVPWEHEPNRGFLRALNALARAAGAIGEKEEYERCSTFLRDSSPAAADALAA
>NZ_CP023701.1|WP_150518610.1|3593812_3594658_-|tryptophan-2,3-dioxygenase
MSNTLDASGAGSDAPNLDFAGTTPYEDYVQADVLTHLQHLRSDDPGEMVFLVTTQVMELWFTVIVHEWETAAAAVREDDLSVATDALKRSLRELEALNASWRPLAHLTPAQFNSYRGALGEGSGFQSAMYRRMEFLLGDKSASMLVPHRGAPRVHAELEKALYEPSLYDEVLRLLARRGLPVPSAALERDLSQRYEPSAGVEAVWTALYADPDAHPDLHRLGEVMTDVAELVWRWRNDHLVATRRAMGAKTGTGGSAGVAWLEKRATKNVFPELWTARSHV
>NZ_CP023701.1|WP_150518609.1|3592572_3593820_-|kynureninase
MSDPIDTPAAAPATATTTGPAPDLRARAAGLDATDGLAGLRARFALPEGVVYLDGNSLGALPAGVPDALADVARRQWGELLIRSWDESAWWTAPERIGDRLAPLVGAAPGQVVVGDSTSVNLFKALVGAARLAGPGRTRLLVDAATFPTDGYIAESAARMTGLTVTPVDPSHAAAAFDADTAVVLLNHVDYRTGRLHDLPALTRAARAAGAVTVWDLCHSAGALPVDLDAHGVDLAVGCTYKYLNGGPGAPAYLYIAERHQQDFDSPLPGWNGHAEPFAMTPGFVPAEGARRGRVGTPDILSMLALEAALDAWAGVGIADVRAKSLALTDFFLECVAAYVPAGRVESVTPAAHAERGSQVSLRTDDARAVMAELISRGVVGDFRAPDVLRFGFTPLYVGFADAERAARTLGHIFG
>NZ_CP023701.1|WP_150518608.1|3591522_3592401_-|alpha/beta-hydrolase-fold-domain-containing-protein
MTDPAAVERDAAEAASAFAHPPVAPDATAAYGDHPDQVVDFYAPHGESAVPAPLVVVLHGGAWRAPYDRQHVTPLAGFLARRGFAVANIEYRRGSSVPHQGAEGPVAGRWPETFDDVAAALDALPRLAAASVPRADVRRTVLTGHSAGGHLALWAAARHVLPPGSPWRLPSAPPLRGVVALAPIADFAVARELGVCGDATAQLLGGERYVAERLPYADPSALLPTGIATAVVQGREDIVVPERVAESYVAAAAQAGELVGLTLLDGVGHFPLIDPAADACAVVAEEIAQLAW
>NZ_CP023701.1|WP_150518607.1|3590158_3590995_-|helix-turn-helix-domain-containing-protein
MAKAANKETAGGATRLVSHLARALREKEKLTQRELGERLGYSAAAISAVETCAQPASDEMLVGLEAEIGGGLGVFEVARELVRLDKYPSHFQDFFLLEQQALSLYLFETEAIYGVFQTEEYARALIAGGFPVLSDRRVDELVEGRMARKVLFGRDPAPLIELILDESVLRRGIGTPAIMRAQCLYLSELAALRNVAVYVLPFGTGFSGEHAGTRGGMNIVETPRHERLVYIETGDESLLISDGAKVSTYSQRYAKIRAQALGPRESLGFIEQVAGDWI
>NZ_CP023701.1|WP_150518606.1|3589946_3590162_-|DUF397-domain-containing-protein
MSTNPLLWFKSSYSNDSGGACVEVALDGRQWSGGGAGCGHTVHVRDSKNPGPTLRLAGEAWAGFTGWAARP
>NZ_CP023701.1|WP_150518605.1|3588063_3589728_-|hypothetical-protein
MSAVAVIAASVGFIPGAAHAAEPVAPPVAAPDAQLTKAAAANFKTYKSPAEKSVRSALPAAKNKGAAAPRAAGAAAGNPNLNMVLAATSTTAHGLEFVTDLISEDASLIVTVEWGDGTRDQRDAYGAGALHYTHTYAELGQYNIKVTVSDPANGVQVVNELPYGTAGSDFTPYTPTRILDTRNGTGAKAGKVGPSGTVGLKVGGNGGIPAGVTAVVLNVTVTNPTNSGFVTVFPDFGERPTTSNVNYEAGQTVPNQVIVPVGKNGYVDLANSSWGGSSIDLIADVTGYFTKSAASGYTPMTPVRFVDTREGLGTSRGQLAGQGTFSTKISNLRGVPAGIKAVALNVTVTNPKQYGHLTVFPSGQAAPDTSSLNFTAGQTIANSVIVPVGSDGKIGVRNGAWGGVDVIVDVVGYYSPASTGSFVPVSPFRRLDTRDRPSGAIPGGYYQPVVFSPDPSEDGISGFVLNATATNTANTGYLAVAPDPNSYEDYERGTVNPPDAPGSSTLNWTKGKTVPNLVQASAGQNGIVDFFNQSWEEWATTDLIVDVFGYYETN
>NZ_CP023701.1|WP_150518614.1|3600994_3602179_-|hypothetical-protein
MAARDLPQDGSVLRRLAAEGVSPWLDGIGRSALDAGEFDHLVEVAGVRGLLCGVESVREDLLRTGPRLPERLPGSAEALVEELLAADARRAGGALLRLLGPDGMVAVPVAPWHRSAAAQVAAARALAHRVGRPNVLVGLRATPEGLAAAVRCLGEGLGVYCGPVFGVTAYEAVLEAWLTGLDRAHRAGLDLGRIAFAAERRLPAPVAEAEAAARLLHACADLRYDDPRWPALVAAGARPHRLLWSGFDPATAAVAVPGLVGWGTGVVLSAEALGPVAREAVLRGETLGGAGGHLRRELARARGGPARAREARAAGRHERQAAARWSRARALAGVRIGSTATRPHAPLPPAAAAPAAPVPVAPDPAPATTAPYPVAAVAAALYRAPWPPPSPRRR
>NZ_CP023701.1|WP_150518615.1|3602341_3602983_-|flavodoxin-family-protein
MTQDTGTGTPLVVIAYDPQGGGAAALAAAARDGAGEEGVRAVLADVAAMGEDGWALLDEADGIVFGAPAHANGASAAFRGFAEESSGRWAARVWADKAASGFATPGHPSGGELGALRYFSVLASQHGMHWVDLDLPPACLSPSGAGAGSAFGPGSLSGFGPGSGPGAAGAAACGAALVEARETVRHLGRRVAQVARLLRARDTGTAPPGVLAG
>NZ_CP023701.1|WP_150518616.1|3603247_3604033_-|AfsR/SARP-family-transcriptional-regulator
MDIDVLGGLRVTENGVPIVAPTPETRLVLAVLAAHANQVVPVSVLADELTGRVPAEHARAVVHSAVRVLREQLAAALHAGPRAVRTADTVLPSVPGGYLFDTGGGRCDLDEFEREAGAGYRAMARGDFEAAARRLRGALDLWTGPAFAGVDAGPRLGERIAALEDSRLAVLGQWVEAGLSLGRHRELHAELSGLLARHTGREQPDEPYLAALRRSGRRVGSLRTLHATAATLDADSGRGASVALRALRRTVLLGAPGARFA
>NZ_CP023701.1|WP_150521938.1|3604261_3604978_-|TetR-family-transcriptional-regulator
MRTRQAILEAAALVFEERGYEAAKLSDIVNIAKVTKGALYFHFDSKEHLAQAVIDAQVASAPDAAPQEYKVQEFVDVGMIFSHRLRHDPLMRASARLTLDQTTLSLDRASPYAAWIELHVSLLTEAKARGELMSTVDPAVPSRLIVGSYAGLNVMAQMLELDLDEQVSALYTHVMPNVVVPSLAIRLDTAPGRGARALYGPQGTHPCTYGCASGIPVLATEDGDADPRAAATAAEAGA
>NZ_CP023701.1|WP_150518617.1|3605157_3605931_-|glucose-1-dehydrogenase
MQGQRQGLLEGKVALITGASSGIGAAAARVFAREGAALVLVARREERLAALVEELREQGARARYAVADVTVRTDAEAAVADAVEAFGRLDCAFNNAGWGLGRTPLHEMDDDLYHRIMDVNVGGVWNFLRPEIAAMLETGGGSIVNNSSVGGLLATPVAAPYVAAKHAVVGLTKAAAAEYAARGIRVNAVAPGTTRTEVVQEWFAAVPGIEAQLHAGTPQPRTAEPYEIAEAAAWLCSDRASFVTGVTMPVDGGFTMV
>NZ_CP023701.1|WP_150521939.1|3606033_3606747_-|HAD-family-phosphatase
MRHLRLVALNIDGVLLNDTFSPVIHGFITRRGGSYDGDVERGIFSQPRAVAALAMAEAAGVDWSAQRVLEVYFEERAAYLAEHPLHVLDGAEELLHRLRALGLRTVCYGGLGKEHFDHYLGHLAHLFDGPGYVCTDAFRPGLREITAEVFGLDHGQALFVDDVARVAQAALDLGAPFIGHPSPFEHGFQGQQMRELGVRHLVGSLGEIDERLLRTVDDEAARAAGADSGGPVTAGAA
>NZ_CP023701.1|WP_150521940.1|3607160_3608138_+|hypothetical-protein
MEFINPAATEPCACPARSDDGLTTTVPRALVHRAAVAEVFLTGMCRPAPERFHITAQWPRGHSFFTPIGGTHYDPMLIAETIRQVGSYLAHEAFDVPLGHQFLLWSLEYSTVPEHLVIGSAPAELDLTVTCPEIRRRGNRLTALGYEVVIRQRGLVVATGRVGYNVTSPAVYRRLRAEQLAKEPVASLPPTPLAPAAVGRLSPFDVVLAGSSRPDLWQLRYDTRHPVLFDHTGDHLPGMVLLEAARQAAVALADDGAAVLPVSVISTYQRYAEFGSPLWIRAEPAPTELGDAGTRPVRVTGTQDGEQVFEAFVSTEPVGAGGPPR
>NZ_CP023701.1|WP_150518618.1|3608228_3609251_-|class-II-fructose-bisphosphate-aldolase
MPIATPEVYNEMLDRAKAGKFAYPAINVTSSQTLHAALRGFAEAESDGIIQISTGGAEFLGGQYNKDMVTGAVALAEFAHIVAAKYDITVALHTDHCPKDKLDGYVRPLLEVSAERVARGLNPLFQSHMWDGSAETLADNLAIGQELLAKAAAAKIILEVEITPTGGEEDGVSHEINDELYTTVDDAIRTAEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKDLQAGVGEKYGKPSPFDFVFHGGSGSTAEEIATALENGVVKMNLDTDTQYAFTRPVVDHMFRNYDAVLKVDGEVGTKSKYDPRTWGKSAEAGMAARVTEACANLRSTGTKLK
>NZ_CP023701.1|WP_150518619.1|3609574_3610114_-|orotate-phosphoribosyltransferase
MTDVRDALLQQIKDKAVVHGKVTLSSGIEADYYIDLRRITLDGEAAPLVGQVMLDLTAELDFDCVGGLTLGADPVATSMLHASAARGGRLDAFVVRKAQKAHGMQRRIEGTDVKGKRCLVVEDTSTTGGSPLTAVEAVREAGGEVVAIATIVDRGAADAIAAAGIPYLTGYRLGDLGLA
>NZ_CP023701.1|WP_150518620.1|3610135_3610921_-|aldose-1-epimerase
MSTQLSAGGAEVTVDQENGCRISSLRIDGTELLRQGPAYGAFPMVPWCGRTENGRFRDGGTVHQLPVNHPPHAIHGFGRDAAWRRVRDTGTEAAFTYDLAEPWPYPGRVTQSVELSADALTLTMGVETYGDSFPAQAGWHPWFRRTLDGGPEARLGFAAAWQEERGADHLPTGRRIDPEPGPWDDCFGMPEGVDVTVTWPGALELRVTSRSEWVVVYDEDPEAVCVEPQSGPPNGLNTLPRLVTPVDPLEISTTWTWRRLP

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Crispr_ID: NZ_CP023701_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_6

3975342-3975452

Orphan

Consensus_repeat	Method
GGGCAGGACCCGGCTCCGGCCTACGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_6

>merge|NZ_CP023701|6|3975342-3975452|CRISPRCasFinder
GCTCCGGCGCAGGCTCCGGCGTACGGGCAGGACCCGGCTCCGGCCTACGGACAGGCTCCGGCCTACGGACAGGCTCCGGCGCAGGGGCAGGACCCCGCTCCGGCCTACGGA

>NZ_CP023701|6|6|3975342-3975452|CRISPRCasFinder
GCTCCGGCGCAGGCTCCGGCGTACGGG	CAGGACCCGGCTCCGGCCTACGGACAGGCTCCGGCCTACGGACAGGCTCCGGCGCAG
GGGCAGGACCCCGCTCCGGCCTACGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150518893.1\|3972198_3973173_-\|SEC-C-domain-containing-protein	unknown	unknown	gnl\|CDD\|376935
NZ_CP023701.1\|WP_150518904.1\|3985432_3986512_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
NZ_CP023701.1\|WP_150518896.1\|3976805_3977711_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176115
NZ_CP023701.1\|WP_150518894.1\|3973997_3974798_-\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176524
NZ_CP023701.1\|WP_150518890.1\|3966453_3966900_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379279
NZ_CP023701.1\|WP_150521962.1\|3986614_3987025_+\|acyl-dehydratase	unknown	unknown	gnl\|CDD\|239539
NZ_CP023701.1\|WP_150518887.1\|3963761_3964415_-\|redoxin-domain-containing-protein	unknown	unknown	gnl\|CDD\|239266
NZ_CP023701.1\|WP_150518900.1\|3981201_3981672_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150518901.1\|3982545_3982857_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150518897.1\|3977790_3978387_+\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|380416
NZ_CP023701.1\|WP_150518892.1\|3970579_3971335_+\|bifunctional-DNA-primase/polymerase	unknown	unknown	gnl\|CDD\|214927
NZ_CP023701.1\|WP_150518903.1\|3984449_3985433_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224462
NZ_CP023701.1\|WP_167536813.1\|3971445_3972018_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150518902.1\|3983049_3984216_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
NZ_CP023701.1\|WP_150518899.1\|3979760_3980723_+\|peptidase	unknown	unknown	gnl\|CDD\|237057
NZ_CP023701.1\|WP_150518898.1\|3978386_3979433_+\|putative-sulfate-exporter-family-transporter	unknown	unknown	gnl\|CDD\|225411
NZ_CP023701.1\|WP_150518891.1\|3967030_3968497_-\|M24-family-metallopeptidase	unknown	unknown	gnl\|CDD\|238520
NZ_CP023701.1\|WP_150518889.1\|3965322_3966138_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150518888.1\|3964489_3965212_-\|DUF1775-domain-containing-protein	unknown	unknown	gnl\|CDD\|377951
NZ_CP023701.1\|WP_150521960.1\|3968590_3970057_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150518893.1\|3972198_3973173_-\|SEC-C-domain-containing-protein	gnl\|CDD\|376935	pfam02810, SEC-C, SEC-C motif. The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.	3.93887e-07
NZ_CP023701.1\|WP_150518896.1\|3976805_3977711_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176115	cd08423, PBP2_LTTR_like_6, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.9804e-57
NZ_CP023701.1\|WP_150518894.1\|3973997_3974798_-\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176524	cd08582, GDPD_like_2, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized bacterial glycerophosphodiester phosphodiesterase and similar proteins. They show high sequence similarity to Escherichia coli glycerophosphodiester phosphodiesterase, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	2.36253e-87
NZ_CP023701.1\|WP_150518890.1\|3966453_3966900_+\|ATP-binding-protein	gnl\|CDD\|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	4.72842e-22
NZ_CP023701.1\|WP_150518887.1\|3963761_3964415_-\|redoxin-domain-containing-protein	gnl\|CDD\|239266	cd02968, SCO, SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c oxidase (COX). They contain a metal binding motif, typically CXXXC, which is located in a flexible loop. COX, the terminal enzyme in the respiratory chain, is imbedded in the inner mitochondrial membrane of all eukaryotes and in the plasma membrane of some prokaryotes. It is composed of two subunits, COX I and COX II. It has been proposed that Sco1 specifically delivers copper to the CuA site, a dinuclear copper center, of the COX II subunit. Mutations in human Sco1 and Sco2 cause fatal infantile hepatoencephalomyopathy and cardioencephalomyopathy, respectively. Both disorders are associated with severe COX deficiency in affected tissues. More recently, it has been argued that the redox sensitivity of the copper binding properties of Sco1 implies that it participates in signaling events rather than functioning as a chaperone that transfers copper to COX II.	7.04093e-48
NZ_CP023701.1\|WP_150521962.1\|3986614_3987025_+\|acyl-dehydratase	gnl\|CDD\|239539	cd03455, SAV4209, SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and gamma-proteobacterial members of this CD have, in addition to a hot dog fold, an N-terminal extension.	4.67301e-43
NZ_CP023701.1\|WP_150518892.1\|3970579_3971335_+\|bifunctional-DNA-primase/polymerase	gnl\|CDD\|214927	smart00943, Prim-Pol, Bifunctional DNA primase/polymerase, N-terminal. Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.	8.12311e-14
NZ_CP023701.1\|WP_150518903.1\|3984449_3985433_+\|hypothetical-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	2.1031e-16
NZ_CP023701.1\|WP_150521960.1\|3968590_3970057_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	1.36966e-34
NZ_CP023701.1\|WP_150518902.1\|3983049_3984216_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	6.13377e-117
NZ_CP023701.1\|WP_150518899.1\|3979760_3980723_+\|peptidase	gnl\|CDD\|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	0.000197602
NZ_CP023701.1\|WP_150518898.1\|3978386_3979433_+\|putative-sulfate-exporter-family-transporter	gnl\|CDD\|225411	COG2855, COG2855, Predicted membrane protein [Function unknown].	2.55395e-67
NZ_CP023701.1\|WP_150518891.1\|3967030_3968497_-\|M24-family-metallopeptidase	gnl\|CDD\|238520	cd01087, Prolidase, Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.	1.17975e-107
NZ_CP023701.1\|WP_150518904.1\|3985432_3986512_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.08576e-27
NZ_CP023701.1\|WP_150518888.1\|3964489_3965212_-\|DUF1775-domain-containing-protein	gnl\|CDD\|377951	pfam07987, DUF1775, Domain of unkown function (DUF1775). Domain found in bacteria with undetermined function. Its structure has been determined and is an immunoglobulin-like fold.	7.43128e-61
NZ_CP023701.1\|WP_150518897.1\|3977790_3978387_+\|cysteine-dioxygenase	gnl\|CDD\|380416	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain. This family contains cysteine dioxygenase (CDO; EC 1.13.11.20), which catalyzes the conversion of cysteine to cysteine sulfinic acid, the first step in the biosynthesis of essential oxidized cysteine metabolites such as sulfate, hypotaurine, and taurine. CDO also plays an important role in the regulation of intracellular cysteine levels in mammals; CDO expression is altered in cancer cells, and abnormal or deficient CDO activity has been linked to Parkinson's disease, Alzheimer's disease, and rheumatoid arthritis. CDO is an iron-dependent thiol dioxygenase that uses molecular oxygen to oxidize the sulfhydryl group of cysteine to generate cysteine sulfinic acid. The CDO active site contains an amino acid-derived cofactor. These enzymes are found in prokaryotes as well as eukaryotes and belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.16073e-26

>NZ_CP023701.1|WP_150518894.1|3973997_3974798_-|glycerophosphodiester-phosphodiesterase
MTHAMPRPIQVVAHRGASEDAPEHTLAAYRKAIEDGADALECDVRLTADGHLVLVHDRRVNRTSNGRGAVSALELADLAALDFGSWKDREESPDWDADPERTSVLTLERLLELAADAGRPVQLAIETKHPTRWAGQVEERLLFLLKRFGLDAPPAEGPHPVRVMSFSARSLHRVRAAAPTVPTVYLMQFITPRMRDGRLPAGVRIAGPGMRIVRNHPAFIRKLQATGHPVHVWTVNEPEDVQLCADLGVEAIITNRPRQVLSQLGR
>NZ_CP023701.1|WP_150518893.1|3972198_3973173_-|SEC-C-domain-containing-protein
MAKKRPAAKTAKPQLNTGEIPVVGAREPCPCGSGRRYKACHGAAAAHAVTEHVQRPFEGLPGECDWVALRELVPAATVPLTLKGGLPEGVPSVTLVTVLPMAWPALRREDGSVLLGLQNESSTGDLGRDMADTLERALAAEPGTPVPARRVPAEGPRLQDLLDVDGVFEPVVHSGFEFWIPESESAQSASPEIAASLERANAAAIPTVKLAGVDAAYWCETPDKNHLRWVMPHPEEKLLDALARLHAAGTSSLGEGTRLVGSFRAHGLVVPVWDLPTGVTADDVEKPAAEFAERLAGALASDAPLTTEERRARGGLTNRQVTLS
>NZ_CP023701.1|WP_167536813.1|3971445_3972018_+|hypothetical-protein
MNLRLIGIGAGVLIILSLPLAGAIAGPDYDGREDGKNGGLFSALGLSDGSRAAAGPAAGRAPAAGRAEPGPPRQPRTDSRCGPELTSPHGLEAQTCVLVGEGRTWGRSYYRNTGGRALDAVLTVMGPAGRTVQIRCEVAAGDEPGLCETPREPSSGTPDAYSAVAEFAVPDDEGALLLRSGSNSPAPGDG
>NZ_CP023701.1|WP_150518892.1|3970579_3971335_+|bifunctional-DNA-primase/polymerase
MREILGRRLQWLRDRIQSLRPAPAPSGPPALLDAALTCATAWEWPVLPGVGRSSTDGSRCACPDPDCVVPGAHPFDPGLLAATTDPRMVTWWWTNRPAAPVLMATGGAAPCAVSLPATAAARALVRLDAQGLRLGPVVATPTRWSLLVAPYSLERLGELLYAKDHVPSSLRFHGEGGYLLLPPSAASGGGEVRWEREPRAADRTRPRSVRGPRTAAGDTVRTLWLPDVEAVVDALVEASTGAPGGGSRLAY
>NZ_CP023701.1|WP_150521960.1|3968590_3970057_-|SpoIIE-family-protein-phosphatase
MGVCDAIWRIAPGGKADAMSAPHLPKVAGIDPAVTASPHTAAPAAPRTAPEAVPPPLAGSIIQDRLAGMVSDLTTLHELTERLARAGDLDSSLREFLRAGATLVGARRALIVLEPSDGLGPRSTIGLGLGHADLGHIETVPRSATSYGRILDGLPDAQGGSEVLPEPGAPAGAGGLGSPADPRHREVAARLGYAASYALPLTAEATGRLGAAVWLYDEQAEPDDRQRDLVGLYVRYAAEHIARMLEVERSRARLATVAEELLPSRLPRIPGVQLAARHRTGPRGGGDWYDALPLPEGALGLAVGSVTGSGPSAVAAMGRLRASLRAYAVMEGEDPVAVLSDLELLLRLTEPARSATALFAYCEPAQRKIVLAGAGHAPPLLIGERRTEYLETSLSAPLGMLSCWEAPSVEIEPAAGETVLLYTDGLLRRTGDAMDRAYARLHAAASGVPRAARDDPAALCDHILRTVLPEGEAADVAEDVVLLAARFE
>NZ_CP023701.1|WP_150518891.1|3967030_3968497_-|M24-family-metallopeptidase
MADELTPETPEEEQPKKTHKQRKNGLYPGVSDELAASMRTGWADTELRGLEPIPQAAHTAARRAALSARFPGDRLVIAAGRLKTRSNDTEYPFRASTEYAYLTGDQTENGVLVLEPAGKSGHTATVYLLPRSDRENGEFWLSGQGELWVGRRHSLTEAEQLLGVPAKDVRELAEALAEAEGPVRTVRGHDALIEAALTDKVTKERDEELRVYLSEARAVKDDFEIGEMQKAVDSTVRGFEDVVKVLDKAEATSERYIEGTFFLRARVEGNDVGYGSICAAGPHACTLHWVRNDGDVRSGDLLLLDAGVETHSLYTADVTRTLPVNGTYTDIQRKIYDAVYESQEAGIAAVKPGAKFRDFHDASQHVLAEKLVEWGLLEGPVERVLELGLQRRWTLHGTGHMLGMDVHDCAAARTEAYVDGTLEPGVCLTVEPGLYFQADDLTVPEEYRGIGVRIEDDILVTEDGNRNLSAGLPRASVEVEAWMARLKG
>NZ_CP023701.1|WP_150518890.1|3966453_3966900_+|ATP-binding-protein
MSIWWSVHLRREAASVPLARRLLLGTMETAGVDPDISFDLSVALTEACANAVEHGGGAGDLPDGAEAYHVTAYLDGDRCRIEVADSGPGFPAATVARRRPALAEHGRGLHLIAELADHVRFRNRPGRGAVVSFDKMLKWRDDSLLGAV
>NZ_CP023701.1|WP_150518889.1|3965322_3966138_-|hypothetical-protein
MTAPHVTQAGAGLRLIRAAVFTAVCVVLSATGHALASCATVPWWALCIGFLGVFSIAAPLAGRRRTLPGLATALTAGQLALHALFGLGQHGSAAAQAPAGSADGSLAALAARLVCGGNSVPLSPADARQILETAGLDPAALAGQAAAHAHSAHAHLGQAATAAPDPGLFSPAMLAGHLLAALGAGLLLGRGDAALFRLVELSRLSADAAPLQPLRVALAFVRALQAGLPSGARPAPRAPRTGDAPAAATGREALQHTVIRRGPPVALVLAA
>NZ_CP023701.1|WP_150518888.1|3964489_3965212_-|DUF1775-domain-containing-protein
MKTSRLSFAAALAAGSVLVLSGTAFAHVSVQPGEATKGGYATISLKVPNERDDASTTQLEVNFPADQPLTSVMPQDVPGWTVKVETSDLAKPLTVHGKQITKAVTKVTWSGGKIESGKFQQFPLSVGKLPEDADQMVLKAIQTYDNGEVVRWIEETKEGAAEPQNPAPVLKLTAATGADHHDAGDASADPAKNGGEAKGGHDEAASDHGSDTTARALGIAGIVIGLGGVAFGVAARRRSA
>NZ_CP023701.1|WP_150518887.1|3963761_3964415_-|redoxin-domain-containing-protein
MRTTRVTAAALAAVAALTLTACGGEPAPSGSVTQIAGGQSTGKAATLLDRPFTKPELVLTDTTGKPWNLREQTKGKPTLIYFGYTNCPDVCPLTMSNIAVAKKALPKADQDNLQVVFVTTDPERDTPESLGSWLRSQDPAFTGLTGDFTTIQAAARALGIGIEAAKKEADGSVVSMHGAQVIAFSPKTDEGYVLYGEGTTVEDYTKDLPKIVKGENP
>NZ_CP023701.1|WP_150518896.1|3976805_3977711_+|LysR-family-transcriptional-regulator
MFDSRHIRTFHAVVTSGSYSAAARALGYTQPAITQQMKALERSVGTPLFTRVGRRMQLTEAGESLSRHAEAILGSLSAAEAQLTAYARLRTGRVRLCGFPSANATLVPDALSGLAAEHPGIQVELLEGEPPGSLRRLERGECDITLAFTYPGLHEEVPEEVAEIRLLEDQLTVLLPTGHPLARRRAVHLADLAGERWIAGCPRCRANLLHECAELGFVPDIRFATDDNLVVQSLVAQGLGVAMMPALVLPSLSLSRVCGRALQPAARRHIAAYVYRDHLRVPATAVVLDALRRVAANRVGC
>NZ_CP023701.1|WP_150518897.1|3977790_3978387_+|cysteine-dioxygenase
MTTTTPARTTTRMAALVREIRSVVDRGLAPDVTAYLVGEVLAPHLGAADLLTPAQREGDPERYRQHVLHAESDGSFSVVALVWLPGQETCIHDHVSWCVAGVHQGAESERRYRLVPGTGTGTGAGSGSGGGSGGGSARLVATEDVVNGQGDVCGFAPPGDIHSVRNSCAGTAISLHVYGADVSRLGTSIRRVYTLPVG
>NZ_CP023701.1|WP_150518898.1|3978386_3979433_+|putative-sulfate-exporter-family-transporter
MALLNRPQGAPVRRVSRETSTPWPGLAAAAAGALVAWLVHRAVPAVPMLTAAVVLGIAAAHLPGPRVFVRGTARPGLSLAGRRLMRIGIVLLGLGLGLDQVVRLGWATVAMVAGVVAATFFGTLWLGRRLGLPGDQPLLIATGYSICGASAIGAVSEVSGSDEEDVAASVALVTLCGTLAIAVLPLLQGPLGLSDPEFGRWVGASVHDVGQVVATAQAAGPGALGEAVLVKLMRVALLAPLVAAVAFSVRARRRGVRTASGRRPAPVPLFVAGFLAAAALRATGVLPDAALEWAHTAQEALLAAALFGLGSAVHLPTLARTGGRAATLGLGAWVVVAGVSYLGVLLTL
>NZ_CP023701.1|WP_150518899.1|3979760_3980723_+|peptidase
MNRRRTVLSTLLSAGALLAGALTAAPPAAASDAPASAAFRQQHVQGFWSAERMRGATPLDVTAAPGAARTPVAAPAARPTAIAPTAPAAASPTAFPQGGGAWTGGGAVVKTSGRVFFTMGDRTASCSGDSITSANGSTVITAGHCVKYQGAWHTNWVFVPAYDNGNAPYGQWSATKTFATDQWAASEDMNMDVGLAVVAPLNGRTLSQAVGAQGILFNGGYNKRMYSFGFPAAAPYDGTKLVYCSGNSGKDFLLTKDHSLSCNMTGGSSGGPWFQDFDEATGLGTQVSVNSFGYTFLPNRMYGPYFGNEAKAAYDKAQTA
>NZ_CP023701.1|WP_150518900.1|3981201_3981672_+|hypothetical-protein
MYSDPPVRTSRNEATVMAHRTTVTSIWTAVLAALVALLASLGFGGKAAPAVAGVSAPAVPAPAAVTARRAAVTARRTWRAMMRGGSLPPTIKQRIRAEAHGKTPSVRRSTTAAAMGAGAGAAVAVGAAVGSGSPAGIVTEVGAPAGAAREALALAA
>NZ_CP023701.1|WP_150518901.1|3982545_3982857_+|hypothetical-protein
MASIRTARVIATVAALPLAVALFGGVATADNGSFANDGSNASVASIIGSGVGGNNNGNSSTSQQVATGSGASNQNNTAQVNGSALTPIHQSNSNVSVNFHPWW
>NZ_CP023701.1|WP_150518902.1|3983049_3984216_+|acyl-CoA-dehydrogenase
MHLAPTEGQLRLRTELRNYFRDLMPDGAPEDPGGQRELLRRIGADGLLGLGWPVEYGGQGRGAEEQFVFFDEAYRAGAPVSMVTLNTVGPTLMKYGTPEQKDYFLPRILAGELVFAIGYSEPEAGTDLAALRTRAVRDGGPDGDWVVDGQKIFTSNAQNADWIWLACRTDPQAPKHKGISIVLVPTQAPGFSWTPIETVGGLTTTATYYDAVRVPAGHLVGPEHGGWGLITNQLNHERVALAAIGMQAEDFYDAALVHARTPDPATGARPADLPWVRSRLAEAHARLAAVRLLNWRLVQDVGGGDLAPGDASGVKFLGTESTVEVYRMCQEVVGEQALIRGPGAEAFGGGELERMNRAAQINTFGGGVSEVQREIVAMMRLGMKGRKR
>NZ_CP023701.1|WP_150518903.1|3984449_3985433_+|hypothetical-protein
MARERAAGVPGGPEAGPADPFHRRLAAFEGSAAAIGGRGKDPVNAPMIRHWCEAVGDANPAYTGPDAIAPPTMLQAWTMGGLSGHGDRTSAYDELLALLDGAGYTSVVATDCEQEYRRPLRPGDTVAFDAVIESVSPRKTTRLGTGHFVTTRMDVRVDGELAGTHRFRILKYAPAARPDGRARSAERPASGARPRASRPRPVVNRDNQGFWDGVRDRKLLIQRCTGCSGLRFPWLPGCHACGSPAWDTVEASGAATVFSYVVMHHPPFPAFDPPYAVALVELAEGVRMVSNITGVPYDKVRISLPVQLEFLTVDDGLVLPVFRGSEA
>NZ_CP023701.1|WP_150518904.1|3985432_3986512_+|acyl-CoA-dehydrogenase
MDFHPTEEQAAAAGLAARIFGDLATHERLAAAGTGSDAELWKALTAAGLPAAVEDIGLLGLVLLLEEQGRSTAQVPFAATCAYGVLPVAAHGTVEQRARLLPALGTGEAVATGAFPNRGRITADRGPLAAATADTGRRTAQGGVRLTGTAPAVPWLREATHVLVPDADGGLWIVRTDAPGVRTAPVETTAPWSAGRLTLTAAEAEPLGAAGAYEAVLATARTAFAGLQAGVCAGSLARAVEYTGVREQFGRPLSTNQGVMLRAADAYMDTEAIRVTTYEAAWRVDEGLPAREHALTAAWWASEAGKRVVHAGQHLHGGMGADLEHPVHRHFLWGRQLDAYLGCGSELLAELGDALAQEG
>NZ_CP023701.1|WP_150521962.1|3986614_3987025_+|acyl-dehydratase
MAVGAIRIGTELPPLEIPVTRTLIVAGAIASRDYQDVHHDAELAREKGSPDVFMNILTTNGLVGRYITDHLGPRAVLRKVAIRLGAPNYPGDTMTLTGTVTALDGDTAQVRVVGANGIGHHVTGTVTVTLAPGSPA

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Crispr_ID: NZ_CP023701_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_7

4722930-4723046

Orphan

Consensus_repeat	Method
GCCGCCCTCCGGGCCGCACGGCACCCGCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_7

>merge|NZ_CP023701|7|4722930-4723046|CRISPRCasFinder
GCCGCCCTCCGGGCCGCACGGCACCCGCCGGGCCGCCGCAGCCGCCGCCGCCGGCGCCGGCGGGCCGGGCCCTGACCCGCGGCCCCGCCGCCCTCCGGGCCGCACCGGCACCCGCCG

>NZ_CP023701|7|7|4722930-4723046|CRISPRCasFinder
GCCGCCCTCCGGGCCGCACGGCACCCGCCGG	GCCGCCGCAGCCGCCGCCGCCGGCGCCGGCGGGCCGGGCCCTGACCCGCGGCCCC
GCCGCCCTCCGGGCCGCACCGGCACCCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150519428.1\|4727065_4728682_+\|DUF2510-domain-containing-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP023701.1\|WP_150519429.1\|4728758_4729487_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP023701.1\|WP_150519426.1\|4724812_4726195_+\|FAD-binding-protein	unknown	unknown	gnl\|CDD\|273050
NZ_CP023701.1\|WP_150519422.1\|4718115_4719003_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224095
NZ_CP023701.1\|WP_150522029.1\|4730401_4732759_+\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|368494
NZ_CP023701.1\|WP_150519427.1\|4726293_4726773_-\|SsgA-family-sporulation/cell-division-regulator	unknown	unknown	gnl\|CDD\|377399
NZ_CP023701.1\|WP_150522028.1\|4723204_4724605_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP023701.1\|WP_150519431.1\|4733219_4733843_-\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238493
NZ_CP023701.1\|WP_150519420.1\|4716346_4716955_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378968
NZ_CP023701.1\|WP_150519421.1\|4717116_4718115_-\|glycine-betaine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270329
NZ_CP023701.1\|WP_150519432.1\|4733987_4735316_-\|nicotinate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236426
NZ_CP023701.1\|WP_150522030.1\|4732872_4733175_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150519425.1\|4721570_4722716_+\|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl\|CDD\|273528
NZ_CP023701.1\|WP_150519417.1\|4714046_4714844_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226011
NZ_CP023701.1\|WP_150519430.1\|4729642_4729918_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150522027.1\|4718999_4720202_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224050
NZ_CP023701.1\|WP_150519423.1\|4720278_4720926_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224095
NZ_CP023701.1\|WP_150519424.1\|4720961_4721438_-\|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
NZ_CP023701.1\|WP_150519418.1\|4714782_4716075_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP023701.1\|WP_150519419.1\|4716071_4716275_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150519428.1\|4727065_4728682_+\|DUF2510-domain-containing-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	9.77862e-20
NZ_CP023701.1\|WP_150519429.1\|4728758_4729487_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.24643e-22
NZ_CP023701.1\|WP_150519422.1\|4718115_4719003_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	2.39831e-59
NZ_CP023701.1\|WP_150522029.1\|4730401_4732759_+\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|368494	pfam05547, Peptidase_M6, Immune inhibitor A peptidase M6. The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homolog of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae.	0
NZ_CP023701.1\|WP_150519427.1\|4726293_4726773_-\|SsgA-family-sporulation/cell-division-regulator	gnl\|CDD\|377399	pfam04686, SsgA, Streptomyces sporulation and cell division protein, SsgA. The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division.	9.17155e-42
NZ_CP023701.1\|WP_150519426.1\|4724812_4726195_+\|FAD-binding-protein	gnl\|CDD\|273050	TIGR00387, Glycolate_oxidase_subunit_glcD., glycolate oxidase, subunit GlcD. This protein, the glycolate oxidase GlcD subunit, is similar in sequence to that of several D-lactate dehydrogenases, including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity. [Energy metabolism, Other].	9.82884e-138
NZ_CP023701.1\|WP_150519421.1\|4717116_4718115_-\|glycine-betaine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270329	cd13611, PBP2_YehZ, Substrate-binding domain YehZ of an osmoregulated ABC-type transporter; the type 2 periplasmic-binding protein fold. Osmoprotectant binding lipoprotein YehZ of Clostridium sticklandii is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. YehZ belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.04052e-146
NZ_CP023701.1\|WP_150519432.1\|4733987_4735316_-\|nicotinate-phosphoribosyltransferase	gnl\|CDD\|236426	PRK09243, PRK09243, nicotinate phosphoribosyltransferase; Validated.	0
NZ_CP023701.1\|WP_150519431.1\|4733219_4733843_-\|isochorismatase-family-protein	gnl\|CDD\|238493	cd01011, nicotinamidase, Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).	9.27368e-73
NZ_CP023701.1\|WP_150519425.1\|4721570_4722716_+\|4-hydroxyphenylpyruvate-dioxygenase	gnl\|CDD\|273528	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines].	0
NZ_CP023701.1\|WP_150522028.1\|4723204_4724605_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.1927e-09
NZ_CP023701.1\|WP_150519417.1\|4714046_4714844_+\|hypothetical-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	1.17123e-33
NZ_CP023701.1\|WP_150522027.1\|4718999_4720202_-\|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224050	COG1125, OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism].	2.18674e-143
NZ_CP023701.1\|WP_150519423.1\|4720278_4720926_-\|ABC-transporter-permease-subunit	gnl\|CDD\|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	7.63407e-52
NZ_CP023701.1\|WP_150519424.1\|4720961_4721438_-\|winged-helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.74308e-27
NZ_CP023701.1\|WP_150519418.1\|4714782_4716075_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.04641e-45
NZ_CP023701.1\|WP_150519420.1\|4716346_4716955_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	2.28945e-11

>NZ_CP023701.1|WP_150519425.1|4721570_4722716_+|4-hydroxyphenylpyruvate-dioxygenase
MTETLDTTPHTAREADPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMKLVAYCGPENGVRETASYVLTNGSARFVLTSVIKEATDRGRSLARHVAEHGDGVVDLAIEVPDARAAYAYAVEHGARGLDEPHEVKDEHGTVVLAAIATYGETRHTLVERRDYTGPYLPGFVAVDPLVEPPAKRTFQAIDHCVGNVELGRMNEWVAFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKVKFPINEPAIAKKKSQIDEYLEFYGGAGVQHIALATNDIVASVRAMRAAGVRFLDTPDSYYDTLGEWAGETRVPVETLRELKILVDRDEDGYLLQIFTKPVQDRPTVFFEMIERHGSMGFGKGNFKALFEAIEREQEKRGNL
>NZ_CP023701.1|WP_150519424.1|4720961_4721438_-|winged-helix-turn-helix-transcriptional-regulator
MGIDDLDGRLIVLLAREPRIGVLEASRRLGVARGTVQARLDRLQSNGVIRGFGPQVDPTALGYPVTAFATLEIKQGQGVDVRAHLDGVPEVLELHTTTGHGDMLCRLVARSNADLQRVIDRVVGFDGIVRASTAIVMENPVPLRIIPLVEQAAEDDSR
>NZ_CP023701.1|WP_150519423.1|4720278_4720926_-|ABC-transporter-permease-subunit
MSFWRYLSSRHEQLLTDAFQHASAVFQCMVVATVLGIAIGLLSYRSGWGGNFAITSTATILTVPSLALIGLLIPLVGLGVPPTVIALTLYGLLPIVRNSIVGLRGVDPSLVDAAKGIGMSRAARLLKVELPLAWPPILTGIRVSTQMLMGIAAIAAYASGPGLGNEIFRGIASLGSANALNQVLAGTIGIVVLALLFDAAYVLLGRLTIPRGIRA
>NZ_CP023701.1|WP_150522027.1|4718999_4720202_-|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein
MRLENLSKRYPGNPNPAVDDVSMEIRAGETVVFVGPSGCGKSTTLKMINRLIEPSSGRIRIGDEDVTDMDPVKLRRKIGYAIQSSGLFPHMTVAENIALVPKMTGWSKAGVKDRVEEMLDLVGLDPREFHGRYPRQLSGGQQQRVGVARALAADPPVLLMDEPFGAVDPITRDHLQDELIRLQHELHKTIVFVTHDFDEAIKLGDRIAVLRERSHIAQFDTPEAILTNPTDDFVSGFVGAGAALKRLNLTRVRDVEIADFPTVSVDDPLQRIFTTLRGGATNELLMLDRRGRPYKWLRRGDLMRAKGSLARAGQLVHDTVTRDATLHDALEAVLTDSGGRVAVTGRRGEYIGVVDMETLMNSVHEMLEADRLAAAEHRHDLEELRHHRTEEELEGGGGRS
>NZ_CP023701.1|WP_150519422.1|4718115_4719003_-|ABC-transporter-permease-subunit
MTTAHPQRSPGERPPGEHEVKGLSFRDELAEGPGATDGPQAPGGPGAAARPARRITWRMLVLPPAALALVVLALYLWITNIPLDAIERNSLGGGNVMLRLRQHIGLTAVSTFWVLVIAIPLGIALTRRGLRRAAPLVTAVANIGQAAPAIGLLALLVIWLGIGPSTAVIGMVAYAVLPVLSNTVAGLRAIDPQLVEAARGIGMSAAGVLRKVELPLAVPLILAGVRTALVLNVGTATLATFGGGGGLGDLITSGIQTQRMPVLIVGSVLTVVLALFVDWLATLAETALTPRGLEA
>NZ_CP023701.1|WP_150519421.1|4717116_4718115_-|glycine-betaine-ABC-transporter-substrate-binding-protein
MGTFGTRGRAGAPRGVAALAALALALAGCGLKSGSPMVDDVVPGSVGRGEPLKGASLTVASKNFSENIVLGQIIGLVFEAAGAEVLDRTNLPGSISAREAVRKGDADAMYEYTGTAWITYLGNTEPIDDPREQWRAVRDADVRNGVVWLPPASLNNTYTLAISRKNNAKYGLKTLSDVAELARRDPSAVTLCVENEFASREDGLPGMEKAYGMRIPAGNIRKMDAGIIYTQVSKSDSCLLGEAFTTDGRIRAMDLDVMEDDKRFFPNYNAAPAINAKTFAKYPVIAKLLDPVTAKLTTGVAQELNAKVDVEGQDPHQVAKDWLLKEGFIKEG
>NZ_CP023701.1|WP_150519420.1|4716346_4716955_-|helix-turn-helix-domain-containing-protein
MPDTPQTPDPRQPQVHLLDARSLRGLAHPLRMRMLATLRHDGPATASQLAGRLGESSGATSYHLRQLAAHGFVEDAPGHGKGRERWWRAVHDGTAFDETLAYDDDPATRGAADLFLHEIATIHTQEMGTWLGDAHSWSQEWRRGADLSDFTLRLTPAQSLELVRRMHALVNEYRDLPAAEGAESVRVHTHAFPRRTGARDAP
>NZ_CP023701.1|WP_150519419.1|4716071_4716275_-|hypothetical-protein
MHAYSHARTHAGRAVELAAEAAAERLARAAAPAAPALRDRLGQALIAAGVRLTRPAHTPARVQRRTA
>NZ_CP023701.1|WP_150519418.1|4714782_4716075_-|MFS-transporter
MNRRPFAAVLAANTISIAGSSLTLIGVPWFVLQTTGSPARAGVVAFCATLPVVVAALVGGPFIDRIGRRRVSAASDLICGVAVGAIPLLHYAGLLEFWMLCALMAVGGLVHTPGLTARYVLLPDLAEHAGTGLTRAAGLYDAVSRGARMIGAAVAGLLIAAFGAETVLLLDAATFGASALLVSAFLRGVPAAEPQRGGAEASFAAYRAEMAEGWAFLARSRLLTGITLMVMMTNGLDQGWSSVLLPVHGTEELGGAGSLGLMISLFGGSALLGALLYGAWGERFPRRAVFAAAFLASGATRYVVAACTDTTLPLAVTMALAGLGAGMLNPILTTVIYEQVPQELRSRVSGVTTAGCELTMPLGGLAAGLLVEGFGATVALLLFGGAYLLTTLAPLVFPAWRGLDAAGPPAVSRTERPLPGPATAATPPRR
>NZ_CP023701.1|WP_150519417.1|4714046_4714844_+|hypothetical-protein
MLSRLSRLPLPAALAVCAVPVVGLLAVAAFAPLPFVIAQPGLTADVLGDRDGKAVIAVDGAPTRATRGQLRMTTIQATGPSTTVTLPHLVDNWFDTTRAVMPKSSVYSSGGTDKEIEAHNLEEMAKSQSTATDAALGFLHKNPEDVRVRLNLADVGGPSAGLLFSLGIVDKLDGDGSGGDLTGGRTIAGTGTISAGGRVGPVGGVALKTQAARRDGATVFLVPKDECSDARSELPAGLRLIPVGTLTDAVESLRSLDRGGAVPSC
>NZ_CP023701.1|WP_150522028.1|4723204_4724605_-|tetratricopeptide-repeat-protein
MIRPARTADDARPPGPSERAASAVGMGAPAAAVDLSALVADREKWVAAHPKDDASWAVLGAAYLEQARRTADTGWFPKAEKALKRSLEVRPAEKGNLDAMTGMGALANARRDYGTGKKWGELLRAQAPKRWSAYPVLVDAYAGLGDYKAAQQAMDRLLELQPGLVGYTRASQVYRDRGWREDATMAMEHAAGAAKAPAEKAYALYRLGELAWERGDTAESLRQFEASLRTDPGQAQALGGRAKALAGLGRGGEAVRDYRLALGRTPVPQLALELGELLEALGRDQEARVPYDMLGALAARDDVHGVDDDVVLGLYEADHGDPAAAVRRLSQEWARHKNMQVADALGWALHRSGEDTAALEYAKKATEPGLRSADFAYHRAMIERGLGDEAAVRRHLEEAMRTNPRFSPLRAPLAKEALAAIGQPGPGGPENLLPTRPWVAPELPKPNPPKKPKPAPPTKPKPSPSR
>NZ_CP023701.1|WP_150519426.1|4724812_4726195_+|FAD-binding-protein
MDADLSAQLTARLLAGLPAEALLTDPQVTASYASDMAGFCAAGTPAAVVLPRTVEQVRHVMRTATALRVPVVPQGARTGLSGAANASDGCIVLSLVKMDRILEVSAVDRIAVVEPGVVNAVLSRAVAELGLYYPPDPSSWEQCTIGGNIGTASGGLCCVKYGVTAEYVLGLDVVLADGRLLTTGRRTAKGVAGYDLTRLFVGSEGSLGVVVRAVLALRPAPPRQLALAAEFPSAAAACAAVCAVMEAGLTPSLLELMDRTTVRAVNALGKMGLPESTEALLLAAFDTPHAAEELAAVAELCTAAGATAVVPADDEAESELLLQARRMSLTALDALRPATMIDDVCVPRSRLAEMLDGTAAIARAYELLIGVCAHAGDGNTHPVVCFDPADEDETRRARESFDAIMALGLSLGGTITGEHGVGVLKKEWLARELGPVGLEMQRAVKHAFDPLGLLNPGKLF
>NZ_CP023701.1|WP_150519427.1|4726293_4726773_-|SsgA-family-sporulation/cell-division-regulator
MQHPVIERELELKLVVSPERSVAVPARLRYLTEDPYAVHITFHTGSSAPVNWTFARELLVEGVFRPCGHGDVRIWPTKIDNRAVLCLALSSPDGDALLEAPAPLVSAWLESTLRTVPPGTEAGRLGLDAALELLLAPTPADELWLRDPWPSDESADGEL
>NZ_CP023701.1|WP_150519428.1|4727065_4728682_+|DUF2510-domain-containing-protein
MTASPGDGEQAAREGYYPDPSIPGYVRYWNGAAWVPGTSRPAPAQAAPPAPAPMEETGPVFLDETSATEALPESGVWQADPLHQGGFGGPRDHRVSWGSPADPAEPATGHAPRRAAAPGAEHATARAADHEGAHGAGHEGARGAGYGAGYGDGHGTGPGAARPAAHAEGYDGGYGTGIGTGTGTGAGPEAARPAAHAAAARPAGTPVGRARPESPDGPGAAGISLARRPFGAPAPAPAAVSASAALAAPAARLPSHAPAGILSARSPAAAPTALAAPAAPAPAPAVPAPAAPQAPAPEWPDAPGGASGARGTGLTSSWPEAAPRTPADAPAPAAPAAPAPEAAGASAPGWEPRAGGARPAPTRPVPAARTATPRAVFEQMADRAVRPAGLPRRIAARALDSLVLGAVAVAVALPRLPAATAHLQSKIDTARAGGRTTTVWLLDGTIAGQLGPALGAVLFFGLFYEVLPTARWGRTPGKKLLGVRVLATATLRPPTVGAALRRWLVYGLLGLPGSLWCLVDRPRRRAWHDRAAGTYVAR
>NZ_CP023701.1|WP_150519429.1|4728758_4729487_+|RDD-family-protein
MSTDQPPPGQPPEDDPFLKKPQEPTPPSGGSPYGSPPPGDGGHPPPPPPGGPGGGYPPPPPPYGGGDPYGGSGGYGMPDPLAGMPPLADFGRRLAARVIDVIIVAVPLFLIQLAFGTNRYTVDTSRGEDVSEVVTKSYSGSGLVMTLISILLYVGYDWWFTRKNGQTLGKKAMGLRVAMLNDGSVPPSNASLSRAAVLWLPTLICCFCLWPIALVISILVDKPYRQALHDKVAKTVVVKVTT
>NZ_CP023701.1|WP_150519430.1|4729642_4729918_-|hypothetical-protein
MPRPTAAQLAYGSATVVVSTLAMLLLSQTSTGLGVAVISAAALALGLLVALTVPAPGRRGRPAARAGAAAAPAGARVPEPRKAGAEHPVHH
>NZ_CP023701.1|WP_150522029.1|4730401_4732759_+|M6-family-metalloprotease-domain-containing-protein
MAACATSATFFSVTAAQADPTPVGAPAAEHQDPTAPSKEQVKHDLEGPYSKQQSQQREAALNQVLSGKKDVEQRGASKVVKLDDKKYVELGREKTDKIFTILVEFGDQVDNTTMYDPDGPGPKPEAPKYGGTPGPLHNTIAQPDRAQDNSTAWRKDFSRSYFQDLYFGTGKGKDSLKTYYEKTSSGRYSVEGEVADWVKVPYNEARYGSNYCGQTNCSNVWDTVKDGVTAWTAAQKKAGKTDAQIKAQLSQYDQWDRYDFDGDGNFNEPDGYIDHFQIVHAGEDESAGGGVQGTNALWAHRWYAYGTQAGKTGPDNNKAGGTQIGDTGIWVGDYTMQPENGGLGVFAHEYGHDLGLPDLYDTSGGGENGVGFWSLMSAGSWLGKGKDSIGDLPGDMTAWDKLQLGWLNYDKAKAATKSTHTLGVSAYNTKDKQALVVELPKKKVQTDVVAPAEGSSQWWSNMGDDLKNTLTRSVDLTGKKSAALSLKGWWDIEAEYDFLYTEVSTDGGTSWTPLAGTADGAALPVDASGSPSLTGASGAWKSLNFPLDAYAGKKVDLRFRYQTDGGAGGKGFTADALAITADGSTLFTDGAENGDNGWTGKGFSRIGANFTKEYAQYYLAENRRYVSYDSTLKVGPYNFGFSNTRPDWVEHYPYQDGLLIWQWDTSQKDNNTSQHPGQGLILPIDANAKPMKWADGTLLRNKIQPYDATFSAYSTDAFTLHKNGESLFVKPKPTNLVFDDRKGKYYYDENPTGSVKVTDTNTKIKIVKETYDGLQMKIEVGPSGK
>NZ_CP023701.1|WP_150522030.1|4732872_4733175_+|hypothetical-protein
MPGGGFVRLPGGSVVVALTLPRPSGEGGNVRVLVHAANRARALTRLRNLGMRAVYLRGNAQPPTPDEVTAVLHHPDGLLWRGAPDVAAELWHPIRALLGR
>NZ_CP023701.1|WP_150519431.1|4733219_4733843_-|isochorismatase-family-protein
MHRALIVVDVQNDFCEGGSLAVAGGADVAAAVTELIGQATPGYRHVVATRDHHVDPGAHFAHPPAEPDYETSWPVHCVAGTEGVGFHPNFAPAVASGAIAAVFDKGAYEAAYSGFEGADENGARLAEWLREREVTEVDVVGIATDHCVKATALDAARAGFTTRVLLDLTAAVAPHTTARALEELREAGVRLVGGGARRVAPDGPDAL
>NZ_CP023701.1|WP_150519432.1|4733987_4735316_-|nicotinate-phosphoribosyltransferase
MNPADLGLPVDVPSTALFTDHYELTMLQAALANGTADRRSVFEVFTRRLPEGRRYGVVGGTGRVLDAVENFRFDGAVLEFLRERAVVDARTLEWLASYRFSGDIWGYPEGEVYFPGSPVLRVEGSFAECVLLETVVLSILNHDSAIAAAASRMSSAAGGRPLIEMGARRTHELAAVAAARAAYVGGFASTSDLAAGFRYGIPTVGTSAHAFTLVHDSERDAFTAQVASLGGGTTLLVDTYDVAEAVRTAVEVAGTGLGAVRIDSGDLLLVAHRVRQQLDELGATGTRIVVTSDLDEYAIASLAAAPVDAYGVGTQLVTGSGHPTCSMVYKLVARAASADPKAALVPVAKKSSGGKTSLGGRKWAARRRDADGVAEAEVVGLGPVPAALAGDQLATLLVKAGEVVTREPLEAARDRHRAALAGLPLSATQLSRGEAVIPTEYV

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Crispr_ID: NZ_CP023701_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_8

5518285-5518368

Orphan

Consensus_repeat	Method
CGGGCACCCCGTCGGCGACGGCCTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_8

>merge|NZ_CP023701|8|5518285-5518368|CRISPRCasFinder
CGGGCACCCCGTCGGCGACGGCCTCCGCCCCGGGCTCCGGCTCCGGATCCCGGAACCGGGCCACCCCGTCGGCGACGGCCTCCG

>NZ_CP023701|8|8|5518285-5518368|CRISPRCasFinder
CGGGCACCCCGTCGGCGACGGCCTCCG	CCCCGGGCTCCGGCTCCGGATCCCGGAACC
GGGCCACCCCGTCGGCGACGGCCTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150520045.1\|5524124_5525270_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP023701.1\|WP_150520034.1\|5512332_5513052_+\|TIGR02234-family-membrane-protein	unknown	unknown	gnl\|CDD\|274046
NZ_CP023701.1\|WP_150520042.1\|5519736_5520558_-\|CoA-ester-lyase	unknown	unknown	gnl\|CDD\|225184
NZ_CP023701.1\|WP_150520046.1\|5526698_5527685_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP023701.1\|WP_150520033.1\|5510827_5512318_+\|anthranilate-synthase-component-I	unknown	unknown	gnl\|CDD\|184152
NZ_CP023701.1\|WP_150520037.1\|5514101_5514911_+\|indole-3-glycerol-phosphate-synthase-TrpC	unknown	unknown	gnl\|CDD\|234710
NZ_CP023701.1\|WP_150520035.1\|5513133_5513385_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150520048.1\|5529001_5533627_+\|glutamate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236968
NZ_CP023701.1\|WP_167536844.1\|5518523_5519660_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|237284
NZ_CP023701.1\|WP_150520044.1\|5521774_5522680_-\|ribokinase	unknown	unknown	gnl\|CDD\|238579
NZ_CP023701.1\|WP_167536945.1\|5525277_5526810_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP023701.1\|WP_150520047.1\|5527952_5528684_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153124
NZ_CP023701.1\|WP_150522099.1\|5522676_5524059_-\|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl\|CDD\|377122
NZ_CP023701.1\|WP_150520031.1\|5509712_5510345_-\|TIGR03085-family-protein	unknown	unknown	gnl\|CDD\|132129
NZ_CP023701.1\|WP_150520039.1\|5515319_5516561_+\|tryptophan-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|235288
NZ_CP023701.1\|WP_150520036.1\|5513455_5513929_+\|DUF2752-domain-containing-protein	unknown	unknown	gnl\|CDD\|378499
NZ_CP023701.1\|WP_150520032.1\|5510437_5510815_+\|phosphoribosyl-AMP-cyclohydrolase	unknown	unknown	gnl\|CDD\|234598
NZ_CP023701.1\|WP_150520043.1\|5520554_5521778_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
NZ_CP023701.1\|WP_150520040.1\|5516557_5517373_+\|tryptophan-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|237285
NZ_CP023701.1\|WP_150520038.1\|5514919_5515132_+\|tryptophan-synthase-subunit(beta)	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150520045.1\|5524124_5525270_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	4.65399e-34
NZ_CP023701.1\|WP_150520034.1\|5512332_5513052_+\|TIGR02234-family-membrane-protein	gnl\|CDD\|274046	TIGR02234, conserved_hypothetical_protein, trp region conserved hypothetical membrane protein. Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	5.88573e-28
NZ_CP023701.1\|WP_150520042.1\|5519736_5520558_-\|CoA-ester-lyase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	1.15859e-50
NZ_CP023701.1\|WP_150520033.1\|5510827_5512318_+\|anthranilate-synthase-component-I	gnl\|CDD\|184152	PRK13571, PRK13571, anthranilate synthase component I; Provisional.	0
NZ_CP023701.1\|WP_150520037.1\|5514101_5514911_+\|indole-3-glycerol-phosphate-synthase-TrpC	gnl\|CDD\|234710	PRK00278, trpC, indole-3-glycerol phosphate synthase TrpC.	1.77929e-123
NZ_CP023701.1\|WP_150520046.1\|5526698_5527685_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	6.63051e-48
NZ_CP023701.1\|WP_150520048.1\|5529001_5533627_+\|glutamate-synthase-large-subunit	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
NZ_CP023701.1\|WP_167536844.1\|5518523_5519660_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	6.66323e-116
NZ_CP023701.1\|WP_150520044.1\|5521774_5522680_-\|ribokinase	gnl\|CDD\|238579	cd01174, ribokinase, Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides and histidine, and for entry into the pentose phosphate pathway. Ribokinase is dimeric in solution.	4.38529e-112
NZ_CP023701.1\|WP_167536945.1\|5525277_5526810_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	6.72724e-22
NZ_CP023701.1\|WP_150520047.1\|5527952_5528684_+\|hypothetical-protein	gnl\|CDD\|153124	cd02433, Nodulin-21_like_2, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_2: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	9.29364e-93
NZ_CP023701.1\|WP_150522099.1\|5522676_5524059_-\|ADP-ribosylglycohydrolase-family-protein	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	8.65898e-34
NZ_CP023701.1\|WP_150520031.1\|5509712_5510345_-\|TIGR03085-family-protein	gnl\|CDD\|132129	TIGR03085, TIGR03085, TIGR03085 family protein. This family, like pfam07398 and TIGRFAMs family TIGR03084, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized. [Hypothetical proteins, Conserved].	1.00917e-78
NZ_CP023701.1\|WP_150520039.1\|5515319_5516561_+\|tryptophan-synthase-subunit-beta	gnl\|CDD\|235288	PRK04346, PRK04346, tryptophan synthase subunit beta; Validated.	0
NZ_CP023701.1\|WP_150520036.1\|5513455_5513929_+\|DUF2752-domain-containing-protein	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	6.25055e-13
NZ_CP023701.1\|WP_150520032.1\|5510437_5510815_+\|phosphoribosyl-AMP-cyclohydrolase	gnl\|CDD\|234598	PRK00051, hisI, phosphoribosyl-AMP cyclohydrolase; Reviewed.	1.94146e-69
NZ_CP023701.1\|WP_150520043.1\|5520554_5521778_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.06267e-134
NZ_CP023701.1\|WP_150520040.1\|5516557_5517373_+\|tryptophan-synthase-subunit-alpha	gnl\|CDD\|237285	PRK13111, trpA, tryptophan synthase subunit alpha; Provisional.	4.04118e-115

>NZ_CP023701.1|WP_150520040.1|5516557_5517373_+|tryptophan-synthase-subunit-alpha
MSTGTIQLLSDTLARAKAEDRAALVAYLPAGFPTVDGAVEAAKAVIAGGADVVEIGLPHSDPVLDGAIIQTADDIALRGGVKIADVLRTVREVHEATGAPILVMTYWNPIDRYGVERFTAELAEAGGAGCILPDLPVQESGLWREHAEKHGLATVFVVAPSSKDARLATITAAGSGFVYAASLMGVTGTRASVGDQAQELVRRTRATTDLPVCVGLGVSNAVQAKEVAGFADGVIVGSAFVKLLLDAPDLPAGLAAVRALAGELAEGVRRS
>NZ_CP023701.1|WP_150520039.1|5515319_5516561_+|tryptophan-synthase-subunit-beta
MSSEFFIPDPEGHTPDTEGYFGDFGGKFIPEALVAAVDEVAVEYEKAKGDPTFTAELNELMVNYTGRPSALTEVPRFAEHAGNARIFLKREDLNHTGSHKINNVLGQALLTRRMGKTRVIAETGAGQHGVATATACALFGLDCTIYMGEIDTERQALNVARMRMLGAEVIAVKSGSRTLKDAINEAFRDWVANVDRTHYLFGTVAGPHPFPAMVRDFHRVIGVEARRQILERAGRLPDAVAACVGGGSNAIGLFHAFIPDADVRLVGFEPAGHGVETGEHAATLTAGEPGILHGSRSYVLQDEEGQITEPYSISAGLDYPGIGPEHSYLKDSGRAEYRAVTDDAAMQALRLLSRTEGIIPAIESAHALAGALDLGKELGRDGLVVVNLSGRGDKDMDTAARYFGLYDVDGETK
>NZ_CP023701.1|WP_150520038.1|5514919_5515132_+|tryptophan-synthase-subunit(beta)
MNHDRPSVRTRPGRRGPVGVPTAHAPLARGCRPRGCRAPARRVHGRRVRYVIGSEPGQVNGMRWRRGSAP
>NZ_CP023701.1|WP_150520037.1|5514101_5514911_+|indole-3-glycerol-phosphate-synthase-TrpC
MSVLDEIIEGVREDLAERQSRVSLDELKERAAKAPQAKDGVAALRGDSVKVICEVKRSSPSKGALAAIADPAGLAADYEAGGAAVISVLTEQRRFGGSLADLEAVRARVDIPILRKDFIVTAYQLWEARAYGADLALLIVAALEQEALVSLIERAESIGLTPLVEVHDEEEVERAVAAGAKIIGVNARNLKDLKVDRSTFERVVQEIPAHIVKIAESGIRGPHDLIAYANEGADAVLVGESLVTGRDPKAAVADLVAAGAHPALRHGRS
>NZ_CP023701.1|WP_150520036.1|5513455_5513929_+|DUF2752-domain-containing-protein
MDASRTPEAVPPPPPPGAPGPPVRPSRARRLAAPALTLAGAVAAFAYVGAVDPNEPGHYPVCPLFRLTGVLCPGCGGLRSAHAFAHGDLATAVGANALAVAGYLVFAAFTALWLVRAVRGGPVPRLAVKPPYWWVLGAAALVFAVVRNFPFGSALAP
>NZ_CP023701.1|WP_150520035.1|5513133_5513385_+|hypothetical-protein
MAGTSHGHTPAAWTGVMIAFIGFCISGAFMVLANPLGFWAGLVVVVLGGVVGMAMKAAGMGAPKTTHRDLAEVIAASKTTVKV
>NZ_CP023701.1|WP_150520034.1|5512332_5513052_+|TIGR02234-family-membrane-protein
MGYVSAVPPPRTDAAADAAHDPDAAHTAGAAPNADAAPDAAPDAGRRGGRRSVAAALLLGALGATVVLLASGRTWARGTAALGSDALPLTADGRAVTGLPASLAIVGLAALVAVFAVRGRSRLLVSGLLALSGLGAVLAALFAADGRQALDAEAARTTADAAAHVAGLTQTAWPHVTAAGGALILLAGLLALRFGKAWPSMGGRYERDGSPRTRTVAPVDPDRPEDLWKALDRGEDPTR
>NZ_CP023701.1|WP_150520033.1|5510827_5512318_+|anthranilate-synthase-component-I
MDLETFRKLAADRRVIPVSRKLLADGDTPVGLYRKLAAERPGTFLLESAENGRSWSRYSFVGVRSDATLTVRDGQAHWIGTPPVGVPTGGDPLDALRATVEALHTPRDAAGGAPPFTGGMVGYLGYDIVRRLERIGEHTTDDLELPELTMLLTSDLAVLDHWDGTVRLIANAINHNDLESGVDEAYADAVARLDTMEADLARPAPYTPTPLPVSELPEFSALWGGEKYRAAVEDVKERIRAGEAFQVVPSQRFETPCRASALDVYRVLRATNPSPYMYLFRFENGFDVVGSSPEALVKVEDGRAMVHPIAGTRHRGATPQEDHELAEELLADPKERAEHLMLVDLGRNDLGRVCEPGSVEVVDFMSVERYSHVMHIVSTVTGRVAQGRTAFDVLTACFPAGTLSGAPKPRAMQIIEELEPSRRGLYGGCVGYLDFAGDSDTAIAIRTALLRDGTAYVQAGAGVVADSVPELEDQECRNKAAAVLRAVGAANRLHGA
>NZ_CP023701.1|WP_150520032.1|5510437_5510815_+|phosphoribosyl-AMP-cyclohydrolase
MSTSSRPGNLDPAIAARLKRSADGLVPAIAQQYDTGEVLMLGWMDDEALHRTLTTGRCTYWSRSRREYWVKGDTSGHFQHVKSVALDCDADTVLVKVDQVGAACHTGTRTCFDTDVLPIAAAENR
>NZ_CP023701.1|WP_150520031.1|5509712_5510345_-|TIGR03085-family-protein
MSTHAKRERLLLADLLESAGPEAPTLCAGWTCRDLAAHVVIRERRPDAAGGLLLGALKARLERTMAEYTAKPYEELVQLIRTGPPKLSVYALKQVDEAANAVEFYVHAEDVRRAQPDWSPRDVDPVFADSLWSRLEKLARLTGRRSPVGLVLRRPDGRTAVARKGVPVVTVTGEPGELTLFCFGRQAAAAVSLDGEPEAVAKLATAELGL
>NZ_CP023701.1|WP_167536844.1|5518523_5519660_+|prolipoprotein-diacylglyceryl-transferase
MDIAYIPSPSTGVIHLGPIPLRGYAFCIIIGVFVAVWLGNRRWVARGGRPGTVADIAVWAVPFGLVGGRLYHVITDYQLYFGEGRNWVDAFKIWEGGLGIWGAIALGAVGAWIGCRLRGIPLPAWADALAPGIALAQACGRWGNWFNQELYGRATDLPWAVEISAGPNRDAGTYHPTFLYESLWCIGVALLVIWADRRFRLGHGRAFALYVAAYCVGRGWIEYMRVDEAHHILGLRLNVWTSIVVFVLAVVYLVLSARLRPGREEVVEPNAEPDPSAKDAEPVAATEGAAAGDGAAKDTGSGKAEPKDAASEDAGSRGAEPEDAPEGGAGSGDAGPQDAPAKADGAAAEPKSTVLTKNGSAADPAAPAGDQAPGTGKH
>NZ_CP023701.1|WP_150520042.1|5519736_5520558_-|CoA-ester-lyase
MILTWLYAPGDRPEVVAKALACGADAVIVDLEDAVPVSRKEYARAATAELLADRPPLPVHVRVNALDSPWGGADLTALAGLHGLAGLRLPKISAPEQVAAAAHRTGGVALHALLESAVAVERAYDIARAHPALHGLSLGEADLCADLAVCAETGLDWCRSRVVVAARAAGLAPPAQSVFPDIRDLEALAVSCARGRALGFLGRAAIHPRQLPVIERAYLPAPEEVAAAAQVLSAARATPGALALPDGRFVDPAVVAAAHRTLALSRRAAARRP
>NZ_CP023701.1|WP_150520043.1|5520554_5521778_-|CoA-transferase
MTSADTPAPHPAGGGPLGGLRVLDLATLFAGPLAATLLGDFGAEVVKVEHPTRPDPSRGHGPAKDGVGLWWKLLGRNKRTMTLDLSAPGGRDTLLRLAATADVIIENFRPGTLERWGLGWPELSAANPRLVLTRVTAFGQQGPYAHRPGFGTLAEAMSGFAAITGEPDGPPTLPPFGLADSIAALTTAYAVMTALAGRDRTGRGQVVDLAIIEPILTVLGPHPLWYDQLGYVQPRTGNRSTNNAPRNTYRSLDGRWLAVSTSAQSVAERVVRLVGRPELVAEPWFATGSGRAAHAHLLDEAVGGWIARHKADEVVAAFEDAQAAVAPVHDVRDVMEDPQYAALDTVTEVEDPELGPIRMQNILFRLSETPGGIRWAGRPHGADTDAVLTELGLTGAEISALRTEGAL
>NZ_CP023701.1|WP_150520044.1|5521774_5522680_-|ribokinase
MTAIAVLGSTNMDLVAYVPKAPRLGETVTGRAFRTVPGGKGANQAVAAARLGGEVVMIGAVGADGFGVRLRSALAAAGVETAALRTVEGPSGTAHITVDDEGGNSIIVVPGANARVTGLEPGDDRRIAAAGALLLQLELPLEAVLAGARAARAHRVRTILTPAPAQPLPAGLLAATDLLVPNEHEAAALTGLTEPHRAASALLRDVPEVVITLGAAGVLYAARGRDPLSVPAPRVRAVDTTAAGDTFVGALAVALGQGRPVPDALRWASAAAALSVQRPGAQDSMPTRAETDAFAASGAAS
>NZ_CP023701.1|WP_150522099.1|5522676_5524059_-|ADP-ribosylglycohydrolase-family-protein
MRLTWAQPEDLVGHELRQAAEDGRDAAAIRRAWLAAGGRPAPERAGASDAPAPPELRALAARLLDDLAALPNPSARAEPTAWEAVTASLRPPPGPPEAAPPAVDPGLRTRLEAAWLGRAVGCLLGKPVEKLPLAAVRALARAAGNWPLDDWFTARGVPPDLLAAHPWNRRSAPTSLAENIDGMPEDDDLNYPLLNLLLLQRHGRSFTTADVASLWLDELPAGRTFTAERIAYRNLLLGLEPPATATHHNPFREWIGALIRADVHGWTNPGDPAAAAAQAHRDATLTHTGNGVYAALLVAAATAEAATGRADVHGALRAGLAAVPPGSRLAEAVRFAVAAARAAAPTAAGFEPVVDALHARYGHYHWVHAVPNTALLAAALTHADGDFTGSVCRAVSGGWDTDSNGATAGALAGLLAGSPRALPDRWTAPLGNRLSTTVPGFDGTGFDALAHLTAQEAARS
>NZ_CP023701.1|WP_150520045.1|5524124_5525270_-|ADP-ribosylglycohydrolase-family-protein
MTLTLEDRAHGALVGAAVGDALGGPVEGWTPDRIVERHGGRVHGIVGPWHEQWRTARPIAPYHKGDGHVTDDTLMTHALVRVYETVRDHLDAYAVADHLVPDLMGTPRWIPELEAQALPLQRIFLAEKWIVARLHYGHVDPREAGSGNIVNCGAAMYMAPVGIVNAGNPAGAYAEALDVAGAHQSSYGREAAGVFAAAVAAACLPGATAASVVDTALSLAKDGTRDAIAAVREAALGHRDFESALAPLRAAVAPYDSVGPDYRNPSLGARRPSRLHSIEELPIALGMLLVADGAYGPSVLGAVNYGRDCDSIATMAGAVAGALGGAAVVPEAWAKQVAEASRLDLHAPAAALAAVSREVFARDRDRRRAHETAFGALTPSR
>NZ_CP023701.1|WP_167536945.1|5525277_5526810_-|ADP-ribosylglycohydrolase-family-protein
MGRGHRPGPRQLPALDAGLPRAGHRGPPDPRIRGPPMTPPPYAPDPPPTPRDPAPASLTPAPAAPALPAAPRAGVVTGPGPAGASSGGRPPDVRERPAPPAPAAADGGGGASRCAGDRARAGAVRTAVLPAGDPAAGGARRIEGLLLGLAAGDAAGWPAARHRASRMPEWTRRLTRELDTFAERNATTTLPVPIALNQPPEPLRLGPSDDAEWAAFAAESVLTAAGVLLSDLSRSRRMRAAIDLAWNALASEVAAAAERAPEVESAVLPLRARISVRAGLGNLAAGLRPPATGHDNPHYFDDAACVRACVLAVVHPGDPGPAADLAEFDARYTQDGDGVHGARAMAAAIATALAGADVDAAVEAALAQLPASTEIGRNARHAVRLARTHTGGGGAFAIVPTLEHEIVDHVYSYGIAAAETVPVALALATASRGAVSEAVPAAACLSRVADSAPALAGALTGALGGGGSIPAAWRGACRTLSGCALPRLAGTDLVELAALLAGTELTSPKG
>NZ_CP023701.1|WP_150520046.1|5526698_5527685_-|ADP-ribosylglycohydrolase-family-protein
MELTACDPQVLLERARGALLGLAVGDALGAPAENMKPSEIRAKWGRIEGFVSDDPAGTDDTEYAIFSGLLLARHGSALAVSHVERAWHHWIADLDEGPFRGAGFSERGTLENLRRGLAAPISAQHRHAWSDGLAMRAAPFGVFAAGRPAEAARLVAIDGCVSHDGEGIYGGQAVAAGVAAAMAGGSPASVVSAALSVIPSDSWTARSLRRAVTAAPRGERAVRSAVVIGGYPWTDLAPEAVGLAFGAFAACRGDFAPSVLTAVNMGRDADTTAAVAGALAGALSGAGAIPADWAAAIGPVRGSCLPSMRGYHVLDIADLLTPEYEGPR
>NZ_CP023701.1|WP_150520047.1|5527952_5528684_+|hypothetical-protein
MSIIDVEAPLHTAHRDNHTHRDVNGGWLRPAVFGAMDGLVSNLALMTGVAGGAVAPHVVVVTGLAGLAAGAFSMAAGEYTSVASQRELVLAELDVERQQLRKHPVDEMEELAELYVSRGVEPPLAREVAMQLSRDPEQALEIHAREELGIDPDDLPSPLVAAVSSFGSFALGALLPLLPYLLGAVSLWPAVLLALAGLFACGAVVSRITARSWWYGGLRQLALGGAAAGVTYILGTWIGGAVG
>NZ_CP023701.1|WP_150520048.1|5529001_5533627_+|glutamate-synthase-large-subunit
MRSASTHSATGPSTTAWSPMDGRPAQQGMYDPRNEHDACGVGFVANLSGEASHTLVEQALTVLRNLEHRGATGSEPDSGDGAGILSQVPDAFLREVAGFELPEAGAYAVGIAFLPADGPAQAAAAEQIEAIAAEEDLTVLGWREVPVTPDLLGNGARATMPAFSQLFVSGASPTRSGAGPRGIELDRRAFVLRKRAEREAGVYFPSLSARTLVYKGMLTTGQLEPFFPDLSDRRFASTLALVHSRFSTNTFPSWPLAHPYRFVAHNGEINTVKGNRNWMKARESQLASEAFGEGALDRIFPICTPDASDSASFDEVLELLHLGGRSLPHSVLMMIPEAWENHTSMDPARRAFYKYHSTQMEPWDGPACVTFTDGTQVGAVLDRNGLRPGRYWVTDDGLVVLGSEVGVLDIDPAKVVRKGRLQPGRMFLVDTAQKRIIEDDEIKAELAGAAPYAEWLETGEIELTDLPEREHIVHTHASVTRRQQTFGYTEEELRIILAPMARTAGEPLGSMGTDSPIAALSERPRLLFDYFTQLFAQVTNPPLDAIREELVTSLLSSLGPQGNLLEPTAASCRSVTLPFPVIDNDELAKLIHVNADGDMPGMKAATLSGLYRVSGGGDALAARLEEIRGEVDAAIAHGAHLIVLSDRHSDAEHAPIPSLLLTSAVHHHLIATKQRTQVGLLVEAGDVREVHHVALLIGYGAAAVNPYLAMESVEDLLRAGTFLSGLEPEQAIRNLIYALGKGVLKVMSKMGISTVASYRGAQVFEAVGLDQAFVDTYFNGTATKIGGAGLEVVAKEVAARHAKAYPASGIAATHRALEIGGEYQWRREGEPHLFDPETVFRLQHATRNRRYDIFKQYTDRVNEQSERLMTLRGLFGFKTQDRPSIPLDEVESVADIVTRFSTGAMSYGSISREAHETLAIAMNQLGGKSNTGEGGEDPDRLYDPARRSSIKQVASGRFGVTSEYLVNADDIQIKMAQGAKPGEGGQLPGHKVYPWVAKTRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANPAARIHVKLVSEVGVGTVAAGVSKAHADVVLISGHDGGTGASPLTSLKHAGGPWELGLAETQQTLLLNGLRDRIVVQTDGQLKTGRDVVIAALLGAEEFGFATAPLVVSGCVMMRVCHLDTCPVGIATQNPVLRERFSGKPEFVVNFFEFIAEEVRELLAELGFRTIEEAVGHAELLDTTQAVTHWKAQGLDLEPLFYVPELPEGAVRHALIEQDHGLAKALDNELIKLAADALNAATAEQAQPVRAQVAIRNINRTVGTMLGHEVTKRFGGAGLPDDTIDLTFTGSAGQSFGAFVPKGVTLRLEGDANDYVGKGLSGGRIVVRPDRGADHLAEYSTIAGNTIGYGATGGEMFLRGRTGERFCVRNSGALVVSEGVGDHGCEYMTGGQAVVLGETGRNFAAGMSGGVAYVVDLDPDNVNAGNTGAVETVLSEQDRQWLHDVVRRHEEETGSTVAAKLLADWSAAADRFSKIIPTTYKAVLAAKDAAELAGLSESETTEKMMEAATHG

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Crispr_ID: NZ_CP023701_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_9

5566391-5566472

Orphan

Consensus_repeat	Method
CCCGCCCCGGCCCGCTTTCTGCCCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_9

>merge|NZ_CP023701|9|5566391-5566472|CRISPRCasFinder
CCCGCCCCGGCCCGCTTTCTGCCCCCGACCCCGGGCCGCCCCTGAGCCCTGGGGCCCCGCCCCGGCCCGCCTTCTGCCCCCG

>NZ_CP023701|9|9|5566391-5566472|CRISPRCasFinder
CCCGCCCCGGCCCGCTTTCTGCCCCCG	ACCCCGGGCCGCCCCTGAGCCCTGGGGC
CCCGCCCCGGCCCGCCTTCTGCCCCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150520084.1\|5573996_5574248_-\|EF-hand-domain-containing-protein	unknown	unknown	gnl\|CDD\|238008
NZ_CP023701.1\|WP_150520075.1\|5561201_5561858_+\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP023701.1\|WP_150520071.1\|5557985_5558288_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240291
NZ_CP023701.1\|WP_150520079.1\|5566770_5568165_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl\|CDD\|99743
NZ_CP023701.1\|WP_150520081.1\|5569647_5571456_-\|bifunctional-metallophosphatase/5'-nucleotidase	unknown	unknown	gnl\|CDD\|236506
NZ_CP023701.1\|WP_150520077.1\|5563220_5563577_+\|chorismate-mutase	unknown	unknown	gnl\|CDD\|181719
NZ_CP023701.1\|WP_150520082.1\|5571658_5572360_+\|SIMPL-domain-containing-protein	unknown	unknown	gnl\|CDD\|377344
NZ_CP023701.1\|WP_150520070.1\|5556559_5557480_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|236099
NZ_CP023701.1\|WP_150520074.1\|5560192_5560966_+\|trypsin-like-serine-protease	unknown	unknown	gnl\|CDD\|238113
NZ_CP023701.1\|WP_150520076.1\|5561952_5563119_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP023701.1\|WP_150520086.1\|5574931_5575678_-\|transcriptional-regulator	unknown	unknown	unknown
NZ_CP023701.1\|WP_150520083.1\|5572505_5573933_+\|pyruvate-kinase	unknown	unknown	gnl\|CDD\|180487
NZ_CP023701.1\|WP_150520087.1\|5575961_5576615_+\|response-regulator	unknown	unknown	gnl\|CDD\|226230
NZ_CP023701.1\|WP_150520088.1\|5576727_5577444_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223487
NZ_CP023701.1\|WP_150520080.1\|5568161_5569571_+\|SidA/IucD/PvdA-family-monooxygenase	unknown	unknown	gnl\|CDD\|226017
NZ_CP023701.1\|WP_167536846.1\|5557772_5557940_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150520078.1\|5563617_5566146_+\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121
NZ_CP023701.1\|WP_150520072.1\|5558343_5559039_-\|hydrolase	unknown	unknown	gnl\|CDD\|319765
NZ_CP023701.1\|WP_150520085.1\|5574371_5574875_-\|FBP-domain-containing-protein	unknown	unknown	gnl\|CDD\|379860
NZ_CP023701.1\|WP_150520073.1\|5559149_5560040_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367191

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150520084.1\|5573996_5574248_-\|EF-hand-domain-containing-protein	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	3.91281e-06
NZ_CP023701.1\|WP_150520075.1\|5561201_5561858_+\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.43224e-67
NZ_CP023701.1\|WP_150520071.1\|5557985_5558288_+\|hypothetical-protein	gnl\|CDD\|240291	PTZ00146, PTZ00146, fibrillarin; Provisional.	0.00310703
NZ_CP023701.1\|WP_150520079.1\|5566770_5568165_+\|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl\|CDD\|99743	cd06450, DOPA_deC_like, DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.	5.6068e-74
NZ_CP023701.1\|WP_150520081.1\|5569647_5571456_-\|bifunctional-metallophosphatase/5'-nucleotidase	gnl\|CDD\|236506	PRK09420, cpdB, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	1.48096e-133
NZ_CP023701.1\|WP_150520077.1\|5563220_5563577_+\|chorismate-mutase	gnl\|CDD\|181719	PRK09239, PRK09239, chorismate mutase; Provisional.	6.77574e-56
NZ_CP023701.1\|WP_150520082.1\|5571658_5572360_+\|SIMPL-domain-containing-protein	gnl\|CDD\|377344	pfam04402, SIMPL, Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	1.16572e-34
NZ_CP023701.1\|WP_150520070.1\|5556559_5557480_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|236099	PRK07791, PRK07791, short chain dehydrogenase; Provisional.	1.21855e-151
NZ_CP023701.1\|WP_150520074.1\|5560192_5560966_+\|trypsin-like-serine-protease	gnl\|CDD\|238113	cd00190, Tryp_SPc, Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.	3.18612e-74
NZ_CP023701.1\|WP_150520078.1\|5563617_5566146_+\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
NZ_CP023701.1\|WP_150520087.1\|5575961_5576615_+\|response-regulator	gnl\|CDD\|226230	COG3707, AmiR, Response regulator with putative antiterminator output domain [Signal transduction mechanisms].	6.01445e-62
NZ_CP023701.1\|WP_150520088.1\|5576727_5577444_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	3.83521e-128
NZ_CP023701.1\|WP_150520080.1\|5568161_5569571_+\|SidA/IucD/PvdA-family-monooxygenase	gnl\|CDD\|226017	COG3486, IucD, Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	2.39593e-152
NZ_CP023701.1\|WP_150520072.1\|5558343_5559039_-\|hydrolase	gnl\|CDD\|319765	cd01624, HAD_VSP_like, vegetative storage proteins and related proteins, similar to soybean VSPalpha and VSPbeta proteins; belongs to the haloacid dehalogenase-like superfamily. Soybean [Glycine max (L.) Merr.] vegetative storage protein VSPalpha and VSPbeta levels were identified as storage proteins due to their abundance and pattern of expression in plant tissues, they accumulate to almost one-half the amount of soluble leaf protein when soybean plants are continually depodded. They possess acid phosphatase activity which appears to be low compared to several other plant acid phosphatases; it increases in the leaves of depodded soybean plants, but to no more than 0.1% of the total acid phosphatase activity in these leaves. This acid phosphatase activity has maximal activity at pH 5.0 - 5.5, and can liberate Pi from different substrates such as napthyl acid phosphate, carboxyphenyl phosphate, sugar-phosphates, glyceraldehyde 3-phosphate, dihydroxyacetone phosphate, phosphoenolpyruvate, ATP, ADP, PPi, and short chain polyphosphates; they cleave phosphoenolpyruvate, ATP, ADP, PPI, and polyphosphates most efficiently. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Soybean VSPalpha and VSPbeta lack this active site aspartate, other members of this family have this aspartate and may be more active. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.26836e-42
NZ_CP023701.1\|WP_150520083.1\|5572505_5573933_+\|pyruvate-kinase	gnl\|CDD\|180487	PRK06247, PRK06247, pyruvate kinase; Provisional.	0
NZ_CP023701.1\|WP_150520076.1\|5561952_5563119_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.04237e-31
NZ_CP023701.1\|WP_150520085.1\|5574371_5574875_-\|FBP-domain-containing-protein	gnl\|CDD\|379860	pfam16571, FBP_C, FBP C-terminal treble-clef zinc-finger. FBP_C is a family from the C terminal end of fibronectin-binding proteins. It forms an extended four-cysteine zinc-finger with a unique structural fold. Fibronectin-binding proteins bind to elongation factor G - EF-G, which is mediated by the zinc-finger binding to the C-terminus of EF-G. FBPs release ribosomes by competing with them for EF-G.	5.6944e-81
NZ_CP023701.1\|WP_150520073.1\|5559149_5560040_-\|hypothetical-protein	gnl\|CDD\|367191	pfam02799, NMT_C, Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain. The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	0.00673179

>NZ_CP023701.1|WP_150520078.1|5563617_5566146_+|aminopeptidase-N
MSALTRTEAQLRAQLLDVQHYDVALDLTDGDETFHSAAVIRFTARTAGDTFVELKPHRLDSVLLDGAPLPPDALHDGRLPLTGLTEGPHELRIDSLMRYSRTGEGLHRFTDPADGETYVYSQMFLDDVQRVFPAFDQPDLKAVFAFTVTAPAHWTVLANGVTTRTGTRDTDGAGIWRSAPTPLVSTYLAAVAAGPWHSVTTEHAGLPFGIHCRRSLAPHLDADAEEILSVTTACFDRYQEKFTEPYPFDSYDQAFVPEFNAGAMENPGLVTFRDEFIYRSAVTDTERQTRAMVIAHEMAHMWFGDLVTLAWFDDIWLNESFAEYMGYQTLTEATRFTDTWTDFAVTRKPWGYDADQRPSTHPVAPAPEDVPDTASALLNFDGISYAKGASALRQLVAWLGEKDFLAGINTHFARHRFANASLADFVDSLAAHTDRDVHAWADAWLRTTGADTLAPRIEETPEGPADPGGWTLAVDRRGSRPHHVAVGVYHRAPGDAGRALERTALLHLDVPSGDVVSASGPRPALLVLNDGDLTYAKVRLDETSVETALRGLSGIPDPLTRAVVWNALRDMVRDGELDPHDYLATASAHLPGETDLAVVQGVLAFARTQIADRYVTPDRRPEALATLTAIARDLLRRTEDGADPGLRLAAVRVLVDSATQPDTLATWLDEGTVPGGPELDPELGWRVLGRLAVLGAVQEADIDAALAADPSATGEEGAARCRAALPTPEAKAAAWDRLFHDDSLSNYLFSATAQGFWQPEQTDLVREYVTRFYPEAVALGARRGPAIAEAAGRWAFPAHAVDEANLRAGHDCLADPDVLPLLRRKLVDQLDDLARAHKVRTG
>NZ_CP023701.1|WP_150520077.1|5563220_5563577_+|chorismate-mutase
MNNSATDNGTGTDAGTGPGGIDESVAAELGRLRDSIDNIDAAVVHMLAERFKCTQQVGHLKARHQLPPADPGREASQIARLRQLAENAKLDPAFAEKLLTFIIAEVIRHHETIAAGEE
>NZ_CP023701.1|WP_150520076.1|5561952_5563119_+|two-component-sensor-histidine-kinase
MSPPAGWARRHPRAADRTRLALSLLLLALVTFEGVLLARQPSLPHATVWISGILVCLSAAPWPAVPLLARAWFAAAVTWAATLLLIFGNHPLAVWGGGEAIALLVLLSQVLQRAPARTAAVLGPLLGLGCMAVPVRDADPGRFTLLFSVLAVVVGAYSLVLRLQSVQRVRDLNAVRTAERLELARELHDLVAHHVTGIVVEARAARFTGVSAERAAEIFGRIETAGDEALGSMRRLVKVLRENAPHEAPHDAPAGTSPVAGLADIRSLTERFSVTGPPVALHVEEGLEDRLPDDVAATAHRIVLEALTNTGKHAATATAVRVGLRTVPAGLEVRVADDGGRPARLSENARGGGYGLAGMTERAEALGGSLTAGPTPEGGWLVTATLPF
>NZ_CP023701.1|WP_150520075.1|5561201_5561858_+|response-regulator
MAIRVVIADDQDMVRTGFRMILESQPDIEVVADVVDGEAALAAVALHRPDVLLLDIRMPRLDGLEVTRRLAGRDGPRIVIVTTFDLDEYVHAALRGGASGFLLKDASPAMLVEAVRAASVGDSLVSPAITVRLLREMAVRAPAAAAARRPAEPLTEREREVVRCLARGLTNAEIAAELFVSLSTVKTHLANVQAKLDARNRVEIAAWAWESGLATGPA
>NZ_CP023701.1|WP_150520074.1|5560192_5560966_+|trypsin-like-serine-protease
MSTLVRFMKRTLAVGAVALAAVSLQPANAGASPAPVVGGTRAAQGEFPFMVRLSMGCGGALYTQQIVLTAAHCVNGSGNNTSITATAGNVDLNSSSTIKVKSTKVLQAPGYNGTGKDWALIKLAQPINLPTLKIAETKAYDSGTFTVAGWGATREGGAQQRYLMKATVPFVSDASCQSSYGGSLVPGEEICAGFSQGGVDTCQGDSGGPMFRRDNANAWIQVGIVSWGEGCARPGYPGVYTEVSTFAAAIKSAAAGL
>NZ_CP023701.1|WP_150520073.1|5559149_5560040_-|hypothetical-protein
MKRNGTPNGPIEHGFPHLDTVRAAITALHRRLTTDGIRAYDTAFAPGDAAFGPDEDLHLGAHRVASAMVRALRLPDARVLVSFRPMEQAATVELTDGPEYFVEVADRFRTHRGDLAAALSHEVAHVLLHRLDLRFATTADNEILTDTAAAYLGAGWLLLDAYRQDALTHQKFGYLTPEEFGYVLAKRGRLIGEDLSARFTSPRAYEAYVRGGALDARDHRRAPLAAAGPAERLRYARARRSGAAAERGAGYRFEGHGAERRVSFPCPVCAQRLRLPVRGPLRARCALCGTVLECAT
>NZ_CP023701.1|WP_150520072.1|5558343_5559039_-|hydrolase
MRSTRRTRVTRTTAAALSAAAAVLTLLPAGAAQAAPAAVAATPPAATGPAPVASGSAPGGNAAILGIDYGTWQRDVASVIDAARPGIEQRIAASPAGEKPAIVLDIDNSSLETDFHWFWTFPTPAIAKVRDLTRYASERGVAIFFVTARPGIVYSLTEHNLKAVGYPVSGLYVRDLPDLFDEVSAYKTGKRAEIEARGYTIIANIGNNQSDLVGGHAERTVKLPDYGGKLS
>NZ_CP023701.1|WP_150520071.1|5557985_5558288_+|hypothetical-protein
MGRNAVVVWIAGGVCLGTWGVLAWIAFDPGLRGVRDGLGGWMVALAVAPAVVTVGLAALLLGGGGGGGGGSRWSGGDGGVGIGGGCGSGCGGCGGCGGGV
>NZ_CP023701.1|WP_167536846.1|5557772_5557940_+|hypothetical-protein
MSTGWIVVLAFFGGFVLLVLVEVVRSGPGGGADREDGTGDGGGCGGADGCGCGEA
>NZ_CP023701.1|WP_150520070.1|5556559_5557480_+|SDR-family-NAD(P)-dependent-oxidoreductase
MTGGAGLCTGRVVIVTGAGRGLGRAHALAFAAEGAKVVVNDLGVGLDGAPGPDGPAARVVAEIEALGGEAVAHGGDIATGGGADSLVECALARFGRMDTLVNNAGFLRDRMLVNLDEGDWDAVVRVHLKGHFLPLRAAAAWWRAEAKAGRRVAARVVNTSSGAGLLGSVGQGNYSAAKAGILGLTLVAAAELERYGVQVNAIAPAARTRMTEQAFAGTMAAPEGGGFDAMAPENVSPLVVWLGSDASAGVTGRVFEAEGGRITVMEGWRPGPTADRGARWSPAEAGEAAAKLLSSARPPLPVYGTR
>NZ_CP023701.1|WP_150520079.1|5566770_5568165_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MTAPPGTPPPLAGGRDGADALRPLLGTVLEALRTGARQRGGPLPAGGPEAVTARVRAALGDVLPDRGTGDHEALRTLVHTLAAGAADPADPLCAAHLHCPPLAVAAAADLAAAALNPSLDSWDQAPAASAVEALLTRALAAEFHPAAARPDALVTTGGTEANQLALLLARERHGPALTVLHGANAHHSVPRAAWLLGLPPARSIPTPTGTLHPADLADALATTTGPVLVTATAGTTDAGLVDPLPEIARLCDRHGRAELHVDAAYGGLLALSPRHRHRVAGLDRARSVTVDLHKLGWQPVAAGLLTVPDTALLAPLAHQADYLNATDDTDAGLPDLLGRSLRTTRRPDALKIAVTLRSLGRDGLVRLIDHTCALAHALARRLDAHPGFEVHAPPTISTVLFRPAHADDEQLAALRRTLLHQGRAVLGRARADGRLWLKATLLNPRTTPGDLDTLVALLEGSTHR
>NZ_CP023701.1|WP_150520080.1|5568161_5569571_+|SidA/IucD/PvdA-family-monooxygenase
MTAQLDAPHDLVGIGIGPFNLSLAALAHGLPQQGAGELATAFYDQRRDFRWHPGLLIDGAALQVPFLADLVTLADPASPWSFLSYLKHKERLFPFYFAEQFHIQRAEYDAYCRWVADRLPGLHFGHQVDAVRWNPERDLFEVDFTQVDADGGAEALGRAYTRNLALGIGTAPHVPEPLRPLVEAPTVPVIHSADYLDHRERILGAGHVTVIGSGQSGAEVFLDLLRARPAGRERLSWLARTPSFAPMEYSKLGLEHFTPDYTRYFHALPEPVRDRLVPAQWQLHKGIDAATIAAIHEELYRRTLHGGWPDAVLTPGVGVRTAGRVATTKVELHLEHLEQGTRSRLTTDAVVLATGYRERPLGRLLAGLDPYVRKDSSGRPRIDDRHRMVLDPGVTGSVFVQNGERHTHGVGAPDLGLVAWRSAAILNTLTGKDPYPQPVRTAFTTFGLDQRDHARPRPVGTLLPLVDHP
>NZ_CP023701.1|WP_150520081.1|5569647_5571456_-|bifunctional-metallophosphatase/5'-nucleotidase
MAFDRRTFLGTTAATGAAVALTGAASAPAAASTPAPAAAHHGPRTYAFTVMGTTDLHGNVFNWDYFTDAEFDDKAHNDVGLAKISTLVDRVRAEKGRRNTLLIDAGDTIQGTQLSYYYAKVDPITARRGPVHPMARAMNAIGYDAAALGNHEFNYGIPVLRRFEEQCDFPLLGANALDAKTLRPAFAPYSMHRLRTPHGRDVKVAVLGLTNPGIAIWDKANVQGKMTFPGLEEQAAKYVPKLRSMGADVVIVSAHSGSSGTSSYGDQLPYVENAAGLVAEKVPGIDAILVGHAHAEIPEYRVKNRATGKDVVLSEPLKWGQRLTLFDFELTWERGRWSVAKVSAKVLNSNTVAEDRKITRLLSDEHRKVVAYVNQVIGTSTRAMSSAEGPVKDVPIIDLINHVQAETVKAALAGTEWAALPVLSQASCFSRTAAIPAGQVTIRDAAGLYPFENTLEARLLTGAQLKDYLEYSARYYVRTAPGDAVDPAKLTNAENIPDYNYDAVYGFTYGIDIAQPVGSRITGLSYQGRPVDPAARFVLAVNNYRASGGGNFPHVPQAKQVWADSDEIRNTIIQWVKAKGTVDPAAFASVDWRLTRAGVPVF
>NZ_CP023701.1|WP_150520082.1|5571658_5572360_+|SIMPL-domain-containing-protein
MTQDASHQPYGTPEVPRVAVRGEASLEVDPEIARIGITVSARGTDRRAALDDLTRRNNAVLDLVKSYGDPVEKLETGAFSITPELTRHGRGERVRAYHGRVHLTAELNDFTTLGELTTRLADLELTTVDGPWWALRPTSPAHGEARRQAVLDAVQRAREYADALGARLAALVELADLGAENALPFQAAPGAGMRTMAFSATEDAGAPPLDLEPQRQSVHAQVNARFTMTPPQL
>NZ_CP023701.1|WP_150520083.1|5572505_5573933_+|pyruvate-kinase
MRRAKIVCTLGPATDSYDQIKALVEAGMDVARLNLSHGTYAEHEERFQRVRKASDETGRSVGILADLQGPKIRLGRFREGPVLLERGDEFTITVEDLEGDRHTCGTTYKGLAADVTTGERILVDDGRVTLEVTAVDGPRVRTTVIEGGMVSDHKGLNLPGVSVSVPALSEKDIDDLRWALRTGADVIALSFVRSGRDIDDVHRIMDEEGHRLPVIAKIEKPQAVENIDDIVAAFDGIMVARGDLGVEMPLEQVPIVQKRAVKLAKRNAKPVIVATQMLDSMIDNSRPTRAEASDVANAVIDGTDAVMLSGETSVGKYPVETVRTMSRIVQAAEEDILAKGLPPLTDRNKPRTQGGAVARAAAEMGDFLDAKFLVAFTQSGDTVRRLSRYRSPIPLLAFTPDQATRSQLNLTWGVQTFLGPHVDSTDAMVAQVEEELLRIGRCVPGDVVVITAGSPPGVTGSTNLVRIHHIGDAVR
>NZ_CP023701.1|WP_150520084.1|5573996_5574248_-|EF-hand-domain-containing-protein
MSEKARKLFEALDLDQDGELTRVEVISALRSKGPTLAARGDLPFWGVGDVDDSSALFDAADQNGDAVLSFEEFAAVVDRRFGW
>NZ_CP023701.1|WP_150520085.1|5574371_5574875_-|FBP-domain-containing-protein
MEPLSEKQIRSSFVNCTKGEAARLRLPLDFAELPWPELDFLGWVDPGAPLRAHLVLPREQGPVGISLRVPSVGRTSAVKSSLCQICLTGHASSGVTLFAAPLAGARGREGNTVGTYICADLACPLYVRGRRQPKLRTARYEESLTLEERLERMAGNLDAFAAKVTAG
>NZ_CP023701.1|WP_150520086.1|5574931_5575678_-|transcriptional-regulator
MYGIDIRRHALGLLGEGLSLNSVSRQTGISRSALRAWQDRIDPLPRLNQAAPCSGPADPVAYAYLLGLYLGDGCISGHPRGGHHLRIACADAWPGLIEQCRVAVLAVRPTDKVYVLQRPGCVAVTAYGRHWTCLFPQHGPGRKHERRIVLEGWQQEIVEAHPWEFVRGLIHSDGCRSDNRTTRIVAGVRRDYVYPRYFFTNRSSDITGLLTTTLDRLGVEWKRANACNVSIARRASVALMDAHVGPKH
>NZ_CP023701.1|WP_150520087.1|5575961_5576615_+|response-regulator
MTAEHESTPTPDADQSHVPPLTTRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGRQAVELAREHRPDLVILDVKMPVLDGISAAEKIAEESIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRFAELKALEKEVADLSLRLETRKLVDRAKSILQTQYGLTEPAAFRWIQKTSMDRRMSMQQVAEAVIEDAEEKKNAAKG
>NZ_CP023701.1|WP_150520088.1|5576727_5577444_-|ATP-binding-cassette-domain-containing-protein
MTALLKVEDLKVAYGKIEAVKGISFEVNEGEIVCLVGTNGAGKTTTLRTLSGLLKPSAGSVTFDGKPLANVPAHKIVAMKLAHSPEGRHIFPRLTITENLQLGAFLRTDKEGIEKDIQRAYDLFPILGERRKQAAGTLSGGEQQMLAMGRALMCQPKLLMLDEPSMGLSPLMMQKIMATITELKATGTTILLVEQNAQAALSLADQAHVMEIGRIVLSGTGQELLHNEDVRKAYLGED

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Crispr_ID: NZ_CP023701_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023701_10

5759409-5759497

Orphan

Consensus_repeat	Method
TGTTCGGTCCGCCCGGACACGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023701_10

>merge|NZ_CP023701|10|5759409-5759497|CRISPRCasFinder
TGTTCGGTCCGCCCGGACACGCGTACGTCTATTTCATCTACGGCATGTGGTTCAGCCTCAACCTGGTGTGCGGTCCGCCCGGACACGCG

>NZ_CP023701|10|10|5759409-5759497|CRISPRCasFinder
TGTTCGGTCCGCCCGGACACGCG	TACGTCTATTTCATCTACGGCATGTGGTTCAGCCTCAACCTGG
TGTGCGGTCCGCCCGGACACGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023701.1\|WP_150522123.1\|5771783_5772902_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP023701.1\|WP_150520225.1\|5753516_5754311_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP023701.1\|WP_150520237.1\|5772919_5773729_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP023701.1\|WP_150520235.1\|5768226_5769498_-\|DUF1015-family-protein	unknown	unknown	gnl\|CDD\|377633
NZ_CP023701.1\|WP_150520229.1\|5756935_5757439_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|224321
NZ_CP023701.1\|WP_150520234.1\|5767336_5768152_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|235640
NZ_CP023701.1\|WP_150520223.1\|5752177_5752423_+\|DUF320-domain-containing-protein	unknown	unknown	gnl\|CDD\|367652
NZ_CP023701.1\|WP_150520228.1\|5756068_5756839_+\|TSUP-family-transporter	unknown	unknown	gnl\|CDD\|376667
NZ_CP023701.1\|WP_150520238.1\|5774261_5774564_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150520222.1\|5751354_5752005_+\|response-regulator	unknown	unknown	gnl\|CDD\|225107
NZ_CP023701.1\|WP_150520239.1\|5774571_5775387_+\|TlyA-family-rRNA-(cytidine-2'-O)-methyltransferase	unknown	unknown	gnl\|CDD\|224110
NZ_CP023701.1\|WP_150520231.1\|5758254_5759037_-\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_CP023701.1\|WP_150520236.1\|5769587_5770637_+\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|319832
NZ_CP023701.1\|WP_150520233.1\|5765846_5767292_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236766
NZ_CP023701.1\|WP_150520224.1\|5752597_5753383_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023701.1\|WP_150520227.1\|5754982_5755978_+\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407
NZ_CP023701.1\|WP_150520226.1\|5754391_5754820_+\|NfeD-family-protein	unknown	unknown	gnl\|CDD\|224501
NZ_CP023701.1\|WP_150522124.1\|5773849_5774197_-\|sterol-binding-protein	unknown	unknown	gnl\|CDD\|379708
NZ_CP023701.1\|WP_150520230.1\|5757660_5758194_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|182339
NZ_CP023701.1\|WP_150522122.1\|5770713_5771775_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464

Protein	Function_ID	Function_description	E-value
NZ_CP023701.1\|WP_150522123.1\|5771783_5772902_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	2.22701e-108
NZ_CP023701.1\|WP_150520225.1\|5753516_5754311_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	5.34962e-91
NZ_CP023701.1\|WP_150522122.1\|5770713_5771775_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	1.81146e-96
NZ_CP023701.1\|WP_150520229.1\|5756935_5757439_-\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	1.26772e-15
NZ_CP023701.1\|WP_150520223.1\|5752177_5752423_+\|DUF320-domain-containing-protein	gnl\|CDD\|367652	pfam03777, DUF320, Small secreted domain (DUF320). Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	1.22066e-17
NZ_CP023701.1\|WP_150520228.1\|5756068_5756839_+\|TSUP-family-transporter	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	6.77514e-25
NZ_CP023701.1\|WP_150520227.1\|5754982_5755978_+\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	4.7994e-70
NZ_CP023701.1\|WP_150520222.1\|5751354_5752005_+\|response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	4.89334e-80
NZ_CP023701.1\|WP_150520239.1\|5774571_5775387_+\|TlyA-family-rRNA-(cytidine-2'-O)-methyltransferase	gnl\|CDD\|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	1.10887e-98
NZ_CP023701.1\|WP_150520231.1\|5758254_5759037_-\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	2.1435e-105
NZ_CP023701.1\|WP_150520236.1\|5769587_5770637_+\|HAD-hydrolase-like-protein	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	9.32536e-94
NZ_CP023701.1\|WP_150520233.1\|5765846_5767292_+\|hypothetical-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	7.49623e-07
NZ_CP023701.1\|WP_150520235.1\|5768226_5769498_-\|DUF1015-family-protein	gnl\|CDD\|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	9.53703e-125
NZ_CP023701.1\|WP_150520234.1\|5767336_5768152_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	3.00019e-06
NZ_CP023701.1\|WP_150520226.1\|5754391_5754820_+\|NfeD-family-protein	gnl\|CDD\|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	2.92696e-17
NZ_CP023701.1\|WP_150522124.1\|5773849_5774197_-\|sterol-binding-protein	gnl\|CDD\|379708	pfam14864, Alkyl_sulf_C, Alkyl sulfatase C-terminal. This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates.	7.39399e-05
NZ_CP023701.1\|WP_150520230.1\|5757660_5758194_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|182339	PRK10257, PRK10257, putative kinase inhibitor protein; Provisional.	9.38698e-60
NZ_CP023701.1\|WP_150520237.1\|5772919_5773729_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	1.90934e-136

>NZ_CP023701.1|WP_150520231.1|5758254_5759037_-|sporulation-protein
MGFRKLFASLGAGGASVDTVITEPNVVPGGIVQGEVRIQGGSVEQQIEGLSVGLQARVEVEGGDQEYKQDVVFTKQRLGGAFQVQAGALHVVPFGLEIPAETPITHFGGQPLHGMSIGVSTELEIARAVDAGDLDAINVHPVPAQQAILDAFRQLGFTFRSADMERGHIRGTRQTLPFYQEIEFLPPSQYRGLNQVELTFVSDGREMDVVLEMDKKPGLFSEGSDTYRCFQVGLHSFQDTDWAAYLNQWIASVGSTRNWL
>NZ_CP023701.1|WP_150520230.1|5757660_5758194_-|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MTEQNRAPLPHDFHPEVPAFTVVSEDLAPGAELGGAQVQSGGNTSPQLRWEGFPAGTKSFAVTCFDPDAPTGSGFWHWVLFDLPVSVTELPAGAGGGKFEGLPAGAVHVRNDYGTKDFGGAAPPAGERHRYVFTVYAVDQEKLGPDADVSPAVVGFNLRFHTLGRAQLVGEYGSAAG
>NZ_CP023701.1|WP_150520229.1|5756935_5757439_-|HNH-endonuclease
MRDTLVLNASFEPLSTVTLNRAVVLVLQAKAVVEQSHPELRVRAATVELPMPRVIRLCRYVRVPFRRHAPWSRRGVLIRDQHRCAYCGRRATTVDHVLPRAQGGGDTWLNTVASCAEDNHRKAARTPEEAGMPLLRRPFVPSPADAMLLALGVAGQGALPEWLERSA
>NZ_CP023701.1|WP_150520228.1|5756068_5756839_+|TSUP-family-transporter
MSIWESLAVFAAGIGAGTINTIVGSGTLITFPVLLATGLPPVTANVSNTLGLVPGSISGAIGYRKELRGQRARILRLGSVSLVGGLAGAVLLLTLPSDSFDTIVPVLIGLALVLVVFQPRLAKALRRRQDAAGGDTGHPDGGPALLSGMLVASAYGGYFGAAQGVLYVGLMGLLLRDDLQRINAVKNVVAAMVNGIAAVLFLFVAEFDWTAVLLIAVGSTIGGQIGAKVGRRLSPTALRAVIVTVGIIAIVQLLVR
>NZ_CP023701.1|WP_150520227.1|5754982_5755978_+|SPFH/Band-7/PHB-domain-protein
MQPIIIVLIILVVLVFIALVKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDSIRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILQAEGVRQSEILRAEGEKQSSILRAEGDAKAAALRAEGEAQAIRTVFESIHAGDADQKLLAYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLSGAMGNFGPMGGGSGFNPQNSGKGDGSGHANGNSAGPAPQERREQPPID
>NZ_CP023701.1|WP_150520226.1|5754391_5754820_+|NfeD-family-protein
MDIDAWVWWLIGAVGLGIPLVLTAMPEFGMFAVGAVAAAVTAALGAGVTAQVLVFVTVSVALIAVVRPIANRHRDQRPQHRSGIDALKGRSAVVLERVDGAGGRIKLAGEIWSARTLDADTSFEPGQSVDVVEIDGATAVVM
>NZ_CP023701.1|WP_150520225.1|5753516_5754311_+|ATP-binding-cassette-domain-containing-protein
MSDVLELVDVSVVREGRALVDQVSWSVKEGERWVILGPNGAGKTTLLNLASSYLFPTKGSAAILGSTLGKVDVFELRPRIGVAGIAMADKLPKRQTVLQTVLTAAYGMTASWQEEYEDIDEQRARAFLDRLGMTDYLDRKFGTLSEGERKRTLIARALMTDPELLLLDEPAAGLDLGGREDLVRRLGRLARDPLAPSMIMVTHHVEEIAPGFTHVLMIRQGKVVTAGPIDLELTSRNLSLCFGLPLVVERNGNDRWTAQGLPLR
>NZ_CP023701.1|WP_150520224.1|5752597_5753383_-|hypothetical-protein
MLFEPRSGRLAAWGNALLAGLVSPDEASMSIVGEDAVHRVEGLPGEPGPVGLTLALGRMRALGVTGLRVALPAPGHPLGLSGPPEFNARALDAEEAVVAVGAAVGLVPEVAEAGPSGDVHTSVIWHCLPVREAPPADVPSLGEAERELAEALREATAALTRLDVAGSGPVADAALSAYRARAEAGREVLAPGYPPRAVRVLALAQRVDLLVSLAYEHGPGGAVAASEMAARAEALRPVERVARRALVAAYNAPVEERERGR
>NZ_CP023701.1|WP_150520223.1|5752177_5752423_+|DUF320-domain-containing-protein
MKNFKKAAAVTMIAGGLIAAGAGVSSAHGGASAEGEALHSPGVASGNLLQVPVNVPVNLVGNTVNVIGLLNGAFGNHGVNF
>NZ_CP023701.1|WP_150520222.1|5751354_5752005_+|response-regulator
MADTPGPIRVLLVDDHQVVRRGLRTFLEVQDDIEVVGEAADGEEGVARAEELRPDVILMDVKMPGTDGIGALRELRGRANPARVLIVTSFTEQRTAVPALRAGAAGYVYKDIDPDALAGAIRSVHAGHVLLQPEVAATLLAQDEQGTAPGRAGTLTDREREVLALIADGRSNREIARALVLSEKTVKTHVSNILMKLDVSDRTQAALWAVRHGITD
>NZ_CP023701.1|WP_150520233.1|5765846_5767292_+|hypothetical-protein
MTTVAATVPRSAVTTVVVGRPVPVTVRRSVATTEAVVPPAVVAAASAVTTAVATVRPTRVAMTTGVAVPPVVAAVSVATTAVATVRASRAVTMTVVAVPRVTVPPTRVATTGVATVPRTRAVMTTVVGSAAVVTTVAVTVRPTRVAMTTGVAVLRSVVTTTVAAVLRATVPPTRVVTTVAVTVRPTPVVMTTVGAVPPVVAAVSVATTAVATVRASRAVTMTVVAVPRATVPPTRVVTTAAGTVRPTRVAMTTGVAVLRSVVTTTVAAVLRATVPPTRVVTTAVATVPRTRAVMTTVVGSAAVVTTVAVTVRPTRVVTTGVATVPRSVVTMTVAAVPRATVPPTRVVTTAVATVRPTRVAMTTGVAVPPVVAAVSVATTAVATAPRTRAGTTGVATVPRSVVTTTAVAVPRVTVRPTRVVTTAVATVPRTRVAMTTGAATVGVTTGVATATSVRTATRSSGCRSTTTSRASRSTPTSVRSS
>NZ_CP023701.1|WP_150520234.1|5767336_5768152_+|tetratricopeptide-repeat-protein
MVARLIDDEPEQAYAYARIALRLASRVAAVREAAGFAAYATQKYSEALAEFRAAKRMTGSVELWPVMADCERGLGRPERALAMAGEPEVQKLDKAGQVEMRLVAAGARRDQGQLEAAIVTLQSPELASSSVQPWTARLRYAYADALLAAGREDEAREWFGKTLEADKDGATDASDRLAEIDGVEFVDAAVEHGDADGDVDVDTDAEDDADVEDDLDDDDDDEDDEQDAAEVAAAERATDVAEYYDEDDDEYEPLEQSAAGDDERETGRDKA
>NZ_CP023701.1|WP_150520235.1|5768226_5769498_-|DUF1015-family-protein
MTTPGNADHGLRLLPFHGLRYVPERVGSLAAVTSPPYDVVVRPDGVDHLESADPHNIVRLILPQAGTPAARNDQAARALRTWIAEGVLGTDPEPALYVYEQRRAGVLQRGLIGALALSPADAGIVLPHEDVMPDVVADRAGLMRATSANLEPLLLTYRGDDPGTGAAAVVERTAGRAPLLSTTTEDGFQHRLWAITDPDDLATVTADLGHRQALIADGHHRWATYLRLQKEHASPTPWDFGLVLLVDTARYPLQVRAIHRMLRRLPVADALAALDGHFRVRTVDGPLPLAVEALADAAERGNAFLLTGDGRFHLVTDPDQALLDRTVRRDRPEAWRRLDATVLHETLLDGLWNVPDTPEHITYIHDTPSTVAMAERHNGTAVLLHPVREEVVRDLARQGVTMPRKSTSFGPKPATGLVLRGMV
>NZ_CP023701.1|WP_150520236.1|5769587_5770637_+|HAD-hydrolase-like-protein
MTRQSRTSPAASERSLHQAYDTALLDLDGVVYAGGEAIAHAVDSLAAARADGMHLAYVTNNALRTPDAVAEHLGELGIPTEAGEVITSAQAVARLISEQVATGSKVLVIGGEGLRVALRERGLEPVDSADEEGLAAVVQGYGGPGLEWARFAEAAYAINRGVPWFASNTDLTIPGARGIGPGNGAAVEVVRIATGAEPQVAGKPQTPMHRETVLRTGAKRPLVVGDRLDTDIEGAFNGEVDSLLVLTGVTDAARLLRAEPRHRPTYVDRDLRGLLTGQPEVREEDGAWACGGWSALVEDGVLELRTEPARAADADPVDGLRALCAAAWSEAGDGAGTLDAEKALARLEL
>NZ_CP023701.1|WP_150522122.1|5770713_5771775_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MVESPPESEPGTARGRSAGAVARPRHGARAAGLFAALVVLALIALLSIAVGAKQMALEEVWHGLFHYAGTPSDVVVRDLRVPRTLLGLMVGLGLGLSGAVMQALTRNPLAEPGILGVNAGAAAAVVSAISFFGANSLNEFVWWAFLGAAVVSVVVYVLGGSRSATPVRLALAGTAASAALLGYINAVQLMDSKALDKLRFWTVGSLSSATMDTVRQVAPFLLVGALLALTLGRPLNAMAMGDDTARALGAHLTRTRIVAVLAITLLCGAATAACGPIVFVGLMIPHLVRAFTGPDMRWVLAYSAVLSPVLLLGADVVGRIVTRPAELQVGIVTALVGGPVFIYLVRRKRMAQL
>NZ_CP023701.1|WP_150522123.1|5771783_5772902_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MHQDRAERRQPAGAADPAGRRDPARPGRSGPRPLRLPGGTSLRVERRALVVGAVLAAAALALSVLLVGTGDFEIAPWDVVRTVLGDGTPATEFIVNDLRMPRAVVALLVGAALGTSGAVFQSVSRNPLGSPDLLGFGYGSAVGALAVIILFHGDAAEVAVGALLGGLLAGAAVYLLAYKKGVQGYRLVLVGIGASAMLVAAVQYLITKAQLTEAGRAMVWLTGSLAGRDWAQVWPLLGLCAVLFPLILGHGRALRMMEMGDDAAHALGVRVERTRLLLMVAAILLTTAASAAAGPISFVALAAPQLARRLTRSPGGNLLTAGLMGSVLLLASDWGSQRAFGSDQMPVGVVTGLVGGVYLLWLLVTERKAGRI
>NZ_CP023701.1|WP_150520237.1|5772919_5773729_+|ATP-binding-cassette-domain-containing-protein
MQRLTAQNVTLGYDQRVIAENLSVEIPDHSFTVIVGPNACGKSTLLRALSRMLKPASGRVLLDGQAIGSMPAKKVAKTLGLLPQSSIAPDGITVADLVSRGRYPHQGLLRQWSPEDERIVVESMASTGVAELADRAVDELSGGQRQRVWIAMALAQQTPLLLLDEPTTYLDIQHQLDVLDLCAELHENQGRTLVAVLHDLNHAARYATHLIALRDGEVVAEGPPSEVVTAALVEKVFGLRCQVIEDPETGTPLVVPAARRARTKAAATA
>NZ_CP023701.1|WP_150522124.1|5773849_5774197_-|sterol-binding-protein
MATIEECREALDHLSGNLAKADGDARGAAALDRSLSCHITDLDRTFTGRLDGGRIRVDALAPGPPAAKAEIRLAMTGDDLVALVAGELKFAKAWASGRVRLEAGFRDLLRLKSLL
>NZ_CP023701.1|WP_150520238.1|5774261_5774564_+|hypothetical-protein
MTDEPAGAAPPATGPAEAAEARSAAGPEAVGAPAGPVALGVVRTPSGHPGVDAHLAGLAAADHLTADGHLAVYEDVHQGLREALSALDAPPAPGPHDNRS
>NZ_CP023701.1|WP_150520239.1|5774571_5775387_+|TlyA-family-rRNA-(cytidine-2'-O)-methyltransferase
MAGVARRRLDAELVRRSMARSREHAAQLIAAGRVTVGGTTATKAATQVETSAALVVRTDDSDPDYVSRGGHKLAGALAAFRPLGLRVEGRRALDAGASTGGFTDVLLRAGVAHVMAVDVGYGQLAWSLQSDDRVTVKDRTNVRELTVEQIDGIPADLVVGDLSFISIGLVLPALVRCTAPDADLVLMVKPQFEVGKDRLGSGGVVRSTELRAEAVRGVAAQAAKLGLGVLGVTASPLPGPSGNVEYFLWLRAGAPALDPADVDRAVAEGPQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP023701_8	8.1\|5518312\|30\|NZ_CP023701\|CRISPRCasFinder	5518312-5518341	30	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	516588-516617	7	0.767
NZ_CP023701_8	8.1\|5518312\|30\|NZ_CP023701\|CRISPRCasFinder	5518312-5518341	30	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	172012-172041	7	0.767
NZ_CP023701_8	8.1\|5518312\|30\|NZ_CP023701\|CRISPRCasFinder	5518312-5518341	30	NC_014309	Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome	1110188-1110217	7	0.767
NZ_CP023701_8	8.1\|5518312\|30\|NZ_CP023701\|CRISPRCasFinder	5518312-5518341	30	NC_001738	Streptomyces clavuligerus ATCC 27064 plasmid pSCL, complete sequence	8799-8828	7	0.767
NZ_CP023701_8	8.1\|5518312\|30\|NZ_CP023701\|CRISPRCasFinder	5518312-5518341	30	MK801724	Gordonia phage PhrostedPhlake, complete genome	30354-30383	7	0.767
NZ_CP023701_8	8.1\|5518312\|30\|NZ_CP023701\|CRISPRCasFinder	5518312-5518341	30	NC_021347	Rhodococcus phage E3, complete genome	124785-124814	7	0.767
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP007795	Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence	252052-252085	8	0.765
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_LR134452	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 10, complete sequence	134048-134081	8	0.765
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_LR134454	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence	253059-253092	8	0.765
NZ_CP023701_8	8.1\|5518312\|30\|NZ_CP023701\|CRISPRCasFinder	5518312-5518341	30	NC_020548	Azoarcus sp. KH32C plasmid pAZKH, complete sequence	588870-588899	8	0.733
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	556265-556298	9	0.735
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	608724-608757	9	0.735
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	210762-210795	9	0.735
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	134162-134195	9	0.735
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP024310	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence	771797-771830	9	0.735
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP006368	Aureimonas sp. AU20 plasmid pAU20a, complete sequence	417563-417596	9	0.735
NZ_CP023701_4	4.1\|2741963\|34\|NZ_CP023701\|CRISPRCasFinder	2741963-2741996	34	NZ_CP023064	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence	592208-592241	9	0.735

1. spacer 8.1|5518312|30|NZ_CP023701|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 7, identity: 0.767

ccccgggctccggctccggatcccggaacc	CRISPR spacer
gtccgggctccggctccggatcgcgggttt	Protospacer
 .******************** ***. ..

2. spacer 8.1|5518312|30|NZ_CP023701|CRISPRCasFinder matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 7, identity: 0.767

ccccgggctccggctccggatcccggaacc	CRISPR spacer
gtcccggctccggctccggatcgcgggttc	Protospacer
 .** ***************** ***. .*

3. spacer 8.1|5518312|30|NZ_CP023701|CRISPRCasFinder matches to NC_014309 (Ralstonia solanacearum CFBP2957 plasmid RCFBPv3_mp, complete genome) position: , mismatch: 7, identity: 0.767

ccccgggctccggctccggatcccggaacc	CRISPR spacer
ccccgggcgccggatccggatcctcgagat	Protospacer
******** **** *********. **. .

4. spacer 8.1|5518312|30|NZ_CP023701|CRISPRCasFinder matches to NC_001738 (Streptomyces clavuligerus ATCC 27064 plasmid pSCL, complete sequence) position: , mismatch: 7, identity: 0.767

ccccgggctccggctccggatcccggaacc	CRISPR spacer
cccccggctccggctccggctccatgagtt	Protospacer
**** ************** ***  **...

5. spacer 8.1|5518312|30|NZ_CP023701|CRISPRCasFinder matches to MK801724 (Gordonia phage PhrostedPhlake, complete genome) position: , mismatch: 7, identity: 0.767

ccccgggctccggctccggatcccggaacc	CRISPR spacer
gctcgggctccggctccggctccggggtcg	Protospacer
 *.**************** *** **. *

6. spacer 8.1|5518312|30|NZ_CP023701|CRISPRCasFinder matches to NC_021347 (Rhodococcus phage E3, complete genome) position: , mismatch: 7, identity: 0.767

ccccgggctccggctccggatcccggaacc	CRISPR spacer
gcacgggctccggctccggctccggggtct	Protospacer
 * **************** *** **. *.

7. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP007795 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p2, complete sequence) position: , mismatch: 8, identity: 0.765

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
cggacaggcgccggcccgctccgggcagccgggg	Protospacer
** .*  ** ************* *******  *

8. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_LR134452 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 10, complete sequence) position: , mismatch: 8, identity: 0.765

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
cacccggtcgccgtcccgctccgcgtagccgccg	Protospacer
*.* *   * *** ***********.********

9. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_LR134454 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 12, complete sequence) position: , mismatch: 8, identity: 0.765

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
accccactctccggccccctccgcgcacccgcgg	Protospacer
  * * * ********* ********* **** *

10. spacer 8.1|5518312|30|NZ_CP023701|CRISPRCasFinder matches to NC_020548 (Azoarcus sp. KH32C plasmid pAZKH, complete sequence) position: , mismatch: 8, identity: 0.733

ccccgggctccggctccggatcccggaacc	CRISPR spacer
agcgtgtagccggctccggattccggaacc	Protospacer
  *  *   ************.********

11. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.735

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
cgcgcccgcgccggcccgcgccgcgagctggacc	Protospacer
********* ********* ***** . . * *

12. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 9, identity: 0.735

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
cacggccgctccggccccctccgcgccttcctgg	Protospacer
*.** ************ ********  .* . *

13. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 9, identity: 0.735

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
cctgtacgctcaggcccgctccgcccagcccatg	Protospacer
* .*. ***** ************ *****  .*

14. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.735

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
gccgcccgccccggcccgctccacgctctccacg	Protospacer
  *******.************.***  .*  **

15. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP024310 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence) position: , mismatch: 9, identity: 0.735

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
gtcgcgacttccggcccgctccgcccggccgcca	Protospacer
  ***   .*************** *.******.

16. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP006368 (Aureimonas sp. AU20 plasmid pAU20a, complete sequence) position: , mismatch: 9, identity: 0.735

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
cgcgcgcgccccggcccgctccgccgttctggtg	Protospacer
***** ***.**************    *.* .*

17. spacer 4.1|2741963|34|NZ_CP023701|CRISPRCasFinder matches to NZ_CP023064 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence) position: , mismatch: 9, identity: 0.735

cgcgcccgctccggcccgctccgcgcagccgccg	CRISPR spacer
gtcgcggcttccggcccgctccgcccggccgcca	Protospacer
  ***   .*************** *.******.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3238296 : 3249566

Streptomyces_phage(88.89%)

tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_150518331.1\|3238296_3239496_+\|tail	phage tail protein	F8UBM9	Clostridium_phage	2.4e-06	43.4
WP_150518332.1\|3239492_3240776_+	tape-measure protein	NA	NA	NA	NA
WP_150518333.1\|3240813_3241725_+\|tail	phage tail protein	A0A1J0MC75	Streptomyces_phage	6.6e-49	43.4
WP_150518334.1\|3241816_3243010_+	hypothetical protein	A0A1V0E646	Streptomyces_phage	2.8e-39	47.0
WP_150518335.1\|3243061_3244246_+	hypothetical protein	A0A1J0MCA6	Streptomyces_phage	3.7e-44	43.0
WP_150518336.1\|3244318_3245413_+	hypothetical protein	A0A1J0MCA6	Streptomyces_phage	1.3e-43	44.3
WP_150518337.1\|3245409_3246510_+	hypothetical protein	A0A1J0MCX4	Streptomyces_phage	5.6e-95	48.5
WP_150518338.1\|3246509_3247223_+	hypothetical protein	A0A1J0MCQ1	Streptomyces_phage	5.5e-11	32.0
WP_150518339.1\|3247257_3247617_+	ATP-binding protein	NA	NA	NA	NA
WP_150518340.1\|3248073_3248985_+	peptidoglycan-binding protein	A0A142K646	Streptomyces_phage	5.5e-88	55.9
WP_150518341.1\|3249314_3249566_+	hypothetical protein	A0A1J0MCA5	Streptomyces_phage	1.6e-26	73.8

DBSCAN-SWA_2

3684556 : 3691083

Lactococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_019056860.1\|3684556_3684760_+	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	6.1e-16	61.2
WP_150521944.1\|3684864_3685290_-	ATP-binding protein	A0A1V0E640	Streptomyces_phage	7.9e-05	42.9
WP_150518677.1\|3685351_3685558_-	hypothetical protein	NA	NA	NA	NA
WP_150521945.1\|3685902_3686106_+	cold shock domain-containing protein	Q9AZD3	Lactococcus_phage	4.7e-16	61.2
WP_150518678.1\|3686276_3686639_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_150518679.1\|3686635_3688006_-	FAD-binding protein	A0A0B5JBT9	Pandoravirus	6.7e-21	25.6
WP_167536933.1\|3688343_3688607_+	MerR family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_073917174.1\|3688955_3689159_+	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	7.3e-17	62.7
WP_150518681.1\|3689523_3691083_+	DEAD/DEAH box helicase	A0A1V0SBR7	Catovirus	2.6e-37	28.1

DBSCAN-SWA_3

5793856 : 5800303

Streptomyces_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_150522126.1\|5793856_5794471_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	1.5e-09	30.5
WP_150520251.1\|5794470_5795982_+	pseudouridine synthase	NA	NA	NA	NA
WP_150520252.1\|5796124_5796742_+	nicotinamide mononucleotide transporter	A0A2I7SAC7	Vibrio_phage	2.5e-12	28.6
WP_150520253.1\|5796738_5797818_+	AAA family ATPase	A0A192Y7D8	Salmonella_phage	8.9e-29	30.7
WP_150520254.1\|5797814_5798555_+	NUDIX domain-containing protein	A0A0E3JJF3	Streptomyces_phage	6.1e-21	45.7
WP_150520255.1\|5798551_5799571_+	ADP-ribosylglycohydrolase family protein	G3M9X5	Bacillus_virus	5.0e-05	29.3
WP_150520256.1\|5799586_5800303_-	nucleotidyltransferase	A0A1J0GW18	Streptomyces_phage	3.7e-15	38.2

DBSCAN-SWA_4

6837662 : 6889236

Bacillus_phage(40.0%)

protease,tail,plate

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_150522226.1\|6837662_6838214_-\|tail	phage tail protein	NA	NA	NA	NA
WP_150521046.1\|6838258_6840223_-\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_150521047.1\|6840222_6840678_-	GPW/gp25 family protein	A0A1D8KJJ7	Synechococcus_phage	1.6e-08	30.2
WP_150521048.1\|6840790_6842650_-	VgrG-related protein	NA	NA	NA	NA
WP_150521049.1\|6842646_6843372_-	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
WP_150521050.1\|6843373_6843811_-\|tail	phage tail protein	NA	NA	NA	NA
WP_167536877.1\|6846890_6847094_-	hypothetical protein	NA	NA	NA	NA
WP_150522227.1\|6847030_6847399_-	hypothetical protein	NA	NA	NA	NA
WP_150521051.1\|6847524_6847968_-\|tail	phage tail protein	NA	NA	NA	NA
WP_150521052.1\|6848090_6849743_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	1.4e-65	32.6
WP_150521053.1\|6850003_6851908_+	AfsR/SARP family transcriptional regulator	NA	NA	NA	NA
WP_150521054.1\|6852057_6853665_+	peptidoglycan-binding protein	NA	NA	NA	NA
WP_150521055.1\|6854123_6856235_-	AAA family ATPase	A0A0R6PCP6	Moraxella_phage	7.9e-21	28.7
WP_150521056.1\|6856182_6856821_-	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_150521057.1\|6856933_6857599_-	response regulator transcription factor	NA	NA	NA	NA
WP_150521058.1\|6857726_6858497_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_150521059.1\|6858509_6858737_-	hypothetical protein	NA	NA	NA	NA
WP_150522228.1\|6859315_6861019_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_150521061.1\|6861076_6862030_+	YihY family inner membrane protein	NA	NA	NA	NA
WP_150521062.1\|6862094_6863066_+	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_167536878.1\|6863062_6866062_-	hypothetical protein	NA	NA	NA	NA
WP_150521064.1\|6866331_6866634_-	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_150521065.1\|6866803_6867859_-	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_150521066.1\|6868145_6869000_-	DMT family transporter	NA	NA	NA	NA
WP_150521067.1\|6869176_6870049_-	alpha-L-glutamate ligase	NA	NA	NA	NA
WP_150521068.1\|6870045_6870987_-	hypothetical protein	NA	NA	NA	NA
WP_150521069.1\|6872964_6873366_+	roadblock/LC7 domain-containing protein	NA	NA	NA	NA
WP_150521070.1\|6873362_6873722_+	DUF742 domain-containing protein	NA	NA	NA	NA
WP_150521071.1\|6873702_6874329_+	ATP/GTP-binding protein	NA	NA	NA	NA
WP_150521072.1\|6874325_6875564_+	cytochrome P450	NA	NA	NA	NA
WP_150521073.1\|6875560_6876814_+	cytochrome P450	NA	NA	NA	NA
WP_150521074.1\|6876903_6877635_+	hypothetical protein	NA	NA	NA	NA
WP_150521075.1\|6878199_6878934_+	DUF1838 family protein	NA	NA	NA	NA
WP_150521076.1\|6879275_6881075_+	S8 family serine peptidase	A0A1B0T6A2	Bacillus_phage	2.2e-32	34.6
WP_150522229.1\|6881305_6884110_+	AAA family ATPase	NA	NA	NA	NA
WP_150522230.1\|6884179_6885058_-	chitinase	A0A2H4JHX4	uncultured_Caudovirales_phage	1.5e-10	34.3
WP_150521077.1\|6885258_6885672_-	RdlA protein	NA	NA	NA	NA
WP_150521078.1\|6885842_6886034_-	DUF5302 family protein	NA	NA	NA	NA
WP_150521079.1\|6886293_6887655_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_150521080.1\|6887937_6888600_+	NAD(P)-binding domain-containing protein	NA	NA	NA	NA
WP_150521081.1\|6888669_6889236_-\|protease	DJ-1/PfpI/YhbO family deglycase/protease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP023701

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection