CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP023689	Streptomyces chartreusis strain ATCC 14922 chromosome, complete genome	19 crisprs	csa3,DEDDh,DinG,Cas14u_CAS-V,WYL,cas3,Cas9_archaeal,c2c9_V-U4,cas4,casR	3	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP023689_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_1

3351843-3351903

Orphan

Consensus_repeat	Method
CGGGAGGACGTGGCGTGACGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_1

>merge|NZ_CP023689|1|3351843-3351903|CRISPRCasFinder
CGGGAGGACGTGGCGTGACGAGGCATTTCACTGTCTTGCAGGAGAACTTGGCGTGACTGGT

>NZ_CP023689|1|1|3351843-3351903|CRISPRCasFinder
CGGGAGGACGTGGCGTGACGAGG	CATTTCACTGTCTTG
CAGGAGAACTTGGCGTGACTGGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150499784.1\|3365801_3366554_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|225749
NZ_CP023689.1\|WP_125530012.1\|3369563_3370070_+\|protein-phosphatase	unknown	unknown	gnl\|CDD\|350348
NZ_CP023689.1\|WP_125527902.1\|3343384_3344296_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP023689.1\|WP_150499782.1\|3360460_3363754_+\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|237108
NZ_CP023689.1\|WP_150499785.1\|3366569_3367589_-\|Ku-protein	unknown	unknown	gnl\|CDD\|238408
NZ_CP023689.1\|WP_150499787.1\|3370161_3370911_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107902849.1\|3368643_3369450_-\|NERD-domain-containing-protein	unknown	unknown	gnl\|CDD\|377990
NZ_CP023689.1\|WP_167537700.1\|3342180_3342678_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP023689.1\|WP_150499776.1\|3338982_3340164_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234964
NZ_CP023689.1\|WP_150499781.1\|3356597_3360464_+\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|237108
NZ_CP023689.1\|WP_150499780.1\|3351918_3356598_+\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|237054
NZ_CP023689.1\|WP_107902832.1\|3347048_3347255_+\|MbtH-family-protein	unknown	unknown	gnl\|CDD\|377081
NZ_CP023689.1\|WP_107902826.1\|3342936_3343167_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP023689.1\|WP_107902824.1\|3341597_3341948_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150499786.1\|3367640_3368522_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|240133
NZ_CP023689.1\|WP_167537701.1\|3347283_3350808_+\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|237108
NZ_CP023689.1\|WP_125527901.1\|3344350_3345166_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NZ_CP023689.1\|WP_150499783.1\|3363750_3365805_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238429
NZ_CP023689.1\|WP_125527900.1\|3345567_3347046_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP023689.1\|WP_167537883.1\|3340428_3340986_-\|response-regulator	unknown	unknown	gnl\|CDD\|381093

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150499784.1\|3365801_3366554_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|225749	COG3208, GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	6.37252e-63
NZ_CP023689.1\|WP_125530012.1\|3369563_3370070_+\|protein-phosphatase	gnl\|CDD\|350348	cd14498, DSP, dual-specificity phosphatase domain. The dual-specificity phosphatase domain is found in typical and atypical dual-specificity phosphatases (DUSPs), which function as protein-serine/threonine phosphatases (EC 3.1.3.16) and protein-tyrosine-phosphatases (EC 3.1.3.48). Typical DUSPs, also called mitogen-activated protein kinase (MAPK) phosphatases (MKPs), deactivate MAPKs by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. All MKPs contain an N-terminal Cdc25/rhodanese-like domain, which is responsible for MAPK-binding, and a C-terminal catalytic dual specificity phosphatase domain. Atypical DUSPs contain the catalytic dual specificity phosphatase domain but lack the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. Also included in this family are dual specificity phosphatase-like domains of catalytically inactive members such as serine/threonine/tyrosine-interacting protein (STYX) and serine/threonine/tyrosine interacting like 1 (STYXL1), as well as active phosphatases with substrates that are not phosphoproteins such as PTP localized to the mitochondrion 1 (PTPMT1), which is a lipid phosphatase, and laforin, which is a glycogen phosphatase.	5.2019e-11
NZ_CP023689.1\|WP_125527902.1\|3343384_3344296_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	9.18032e-10
NZ_CP023689.1\|WP_150499782.1\|3360460_3363754_+\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP023689.1\|WP_150499785.1\|3366569_3367589_-\|Ku-protein	gnl\|CDD\|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	8.92754e-112
NZ_CP023689.1\|WP_107902849.1\|3368643_3369450_-\|NERD-domain-containing-protein	gnl\|CDD\|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	0.000112655
NZ_CP023689.1\|WP_167537700.1\|3342180_3342678_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.38986e-15
NZ_CP023689.1\|WP_150499776.1\|3338982_3340164_-\|hypothetical-protein	gnl\|CDD\|234964	PRK01611, argS, arginyl-tRNA synthetase; Reviewed.	5.43544e-20
NZ_CP023689.1\|WP_150499780.1\|3351918_3356598_+\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|237054	PRK12316, PRK12316, peptide synthase; Provisional.	0
NZ_CP023689.1\|WP_107902832.1\|3347048_3347255_+\|MbtH-family-protein	gnl\|CDD\|377081	pfam03621, MbtH, MbtH-like protein. This domain is found in the MbtH protein as well as at the N-terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.	3.95249e-27
NZ_CP023689.1\|WP_107902826.1\|3342936_3343167_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.90999e-21
NZ_CP023689.1\|WP_150499781.1\|3356597_3360464_+\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP023689.1\|WP_150499786.1\|3367640_3368522_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|240133	cd04863, MtLigD_Pol_like, MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. MtLigD is monomeric and contains an N-terminal Pol domain, a central phosphoesterase module, and a C-terminal ligase domain. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The MtLigD Pol domain is stimulated by manganese, is error-prone, and prefers adding rNTPs to dNTPs in vitro. The MtLigD Pol domain has been shown to prefer DNA gapped substrates containing a 5'-phosphate group at the gap.	4.02898e-115
NZ_CP023689.1\|WP_167537701.1\|3347283_3350808_+\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_CP023689.1\|WP_125527901.1\|3344350_3345166_-\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	2.74155e-124
NZ_CP023689.1\|WP_150499783.1\|3363750_3365805_+\|hypothetical-protein	gnl\|CDD\|238429	cd00833, PKS, polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or more large multifunctional proteins and iterative type II PKSs, complexes of several monofunctional subunits.	1.61726e-165
NZ_CP023689.1\|WP_125527900.1\|3345567_3347046_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.56269e-59
NZ_CP023689.1\|WP_167537883.1\|3340428_3340986_-\|response-regulator	gnl\|CDD\|381093	cd17538, REC_D1_PleD-like, first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains. PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.58238e-30

>NZ_CP023689.1|WP_167537701.1|3347283_3350808_+|amino-acid-adenylation-domain-containing-protein
MHELFAQQARRTPAATALVHGGQRLSYGELDARADRLAGLLRRHGVRPGALVGVYLERSAEMVVALLGTLKAGAGHVMLDPDFPAERLRAMAADAGVGVVVSRRGDRQPVTAAVSVAVEDAEQAERIEPVAVRPHDPACVMFTSGSTGRPKGIVAPHSAITGTLTGQDFASFGTGAVWLQCSPVSWDAFALELWGPLLNGGLCVLHPGQRPDPVVIAELVDRHAVTSLYLSASLFHVVVDEYPRALDGVRELIVGGEPLSPAHAARALRRHPGLRLSNGYGPVEGMVFLTVHPITAEEVRDGRPVPIGRPLAGKRLRVLDERLRPVADGGAGELYAAGAGVALGYCGRPELTAERFVADPYGPSGERMYRTGDLVRRRTDGVLEYLGRADSQVKIRGFRVEPGEVETVLAGHPGVVRAAVVARPDGTGEKRLVAYVVPRDGDLRRPSEGELRTHAARLLADYLVPAAFVLLDALPLTPNGKLDRAALPEPGPVTGSLGSAAGRRPSGPVEEALCGLFSEVLGVASVGPEDDFFELGGNSLMVARLLGRIRLTLGARVGVRTLFECRTPATLLPHVEETAGKGDPADAPAPVPAGDTLPLSHAQRRLWFLDRVDAGTAYTLPVLVRLRGAVDAAALRAALGDVAARQAVLRTVFEESDGEPRQRVLDGAGARPRLREVRVRSGELAGAVAGAARHRFDLAAELPLHAVLFGVTDRPDEHALLLVLHHIAGDGWSLPPLFRDLSRAYAARTAGAVPEATAPPVPYADFARRQRERLGTADDPGSLTSEQLVFWRKALTGLAPGGPLLPRRPGRPAVPGRDADTVVRRLDARTHARIVDAAREQGATLFMALHAALATALVRTGAGEDLAVGSPIAGRGHDGTVDDVVGFFVNMLVLRTDASGDPTARQLLARIRETALDAFAHQDVPFEEVVDALGPVRPPGRQPFTEVVLALQNNARAEVGLPGATTGVEPLRTGTARFELLVDVTDDHSPSGAPDGMTLVFEYRTSCLEPEFVNGLADAVVEALRAAAAEPDLPLSRLPLPEPSRRADPARDAVLTPAPADDGPADSALLREITAVWSDVLGVERVGPHDDFFRLGGNSLRAVRVAARLTGAGRTVTAAQLFTSPTVAALAAELERAPAEAPAAPAPIPRRPRVPRQPGRAGRTDTSQKEVPWT
>NZ_CP023689.1|WP_107902832.1|3347048_3347255_+|MbtH-family-protein
MTTNPFEDENGTYLVLTNAEGQYSLWPEGIAVPDGWDVALSASSRAECLAHVEANWTDICPAPAGADA
>NZ_CP023689.1|WP_125527900.1|3345567_3347046_+|MFS-transporter
MADAARSQDDTAHDGGKAGRFTGMGPFMLVWSGQAVSLVGNSVLRFAFVFETWSATGRATALTTLSLCALLPQVLLSPLAGAFVDRVNRRTALQLADGGGLLVVALLAVLHFTGGLHTWEVYGAVMLLGGAAAFQFPALGAAVPLLVDKRQLQRANSLLASAKSTADVGGPALGGLLVAFSGIGFILVADLVSFALALAAIRVVRMRGDTGPKAKPGGGPRKKLIAEAVEGMRFLFRFPSLRDLMLAFCFVNLVMVFGFAAVQPMVLARSGGETSALASVNTAIGVGGVAGGLLMAAWSGPRNRARGMLLGIIGMCLSAQVAMALAGEVVGWCAAILVGAALMPMINGTMQAIVQTKVPQEWHGRVFGAVVFLSQLSVPLATAVSGPLADHVFEPQAADGAGIFVVLGPLLGDGPGSGMAAMLLIAGLCGVTVAVLSMSRRTVREIDSLLPDVTDDSAESDDGDDSARPGDPEAPGSTDKPDNPENKALVEG
>NZ_CP023689.1|WP_125527901.1|3344350_3345166_-|SAM-dependent-methyltransferase
MEPGKLSTSIDATVPTAARMYDHYLGGKDNYASDRAACEELDKVVPSTRALALNNRRFLQRVVGTLAGDFGIRQFLDHGSGLPTQNNVHQVAQAVDPASRVVYVDNDPMVLVHGRALLDQNNNTAVIHADMRETDQIFSHPDTERLIDFSQPVAVLFNSVFHCIPDSDTDGPLAVARRVRERLAPGSFMVMCQLVSEDPEVRKFVTDFMDQATQGHWGRVRQQKDVAEYFDGLEILEPGLVEVSTWRPDTEVAPRQLTQEWIEFGGAGRLV
>NZ_CP023689.1|WP_125527902.1|3343384_3344296_+|helix-turn-helix-domain-containing-protein
MSPESPRISRLEPYLDRTEPAPTLLKMLVGVQLGGLREDLGLSQDQVARAVGFSPAKLSRIEAGKGRRPPTEADVRALLEHYGTEEYEASVLLQLLRRAGEPGWWQRYDKRLMPEWFDRLVGLQEAATSIRTFELQYVPGLLQTDDYTRAVVERGLPTAPPREVQRRVELRMRRRQLLHRPDAPQLWAVVDESVLLRVLGSREVMHAQLEHLVEMAQRPHVTVQIVPLDVTNASAPAMPITYLRFGGVDLPDIVYLEHIKSAAFLEDRDETEEYRLALDRLGDEALNPRESLERLRETMKRYA
>NZ_CP023689.1|WP_107902826.1|3342936_3343167_+|DUF397-domain-containing-protein
MPTAPNGVRADSLGVRWIKSRHSNAEGNCVEVAALGDGSVAMRNSRHPDGPALVYTPAEIAAFLAGAKDGEFDHLA
>NZ_CP023689.1|WP_167537700.1|3342180_3342678_-|ATP-binding-protein
MRTAPPAHSGPPGPRRLATPESEHTAPRSAVLRLVGAERGCAEARDFVRRTLGSWELDHCGPDALTVVTELLANAVLHAAPHSAARPSADPGIWLRLGVRRPAHLVCAVTDPSDRPPVYPHTSDPFDEHGRGLRIIDSLSEHWGWTRRHPLGKTVWAMLPTAGDS
>NZ_CP023689.1|WP_107902824.1|3341597_3341948_-|hypothetical-protein
MNTDPVSGYQTYDQHPPQDRTARNRATARRASLVICTIADISAGLLGLWIVLYLLDANQGNAFVEFVHGAADLLSGWARDIFTMDTEGLRVILNYGLPAVLYLALGHGIAARLNRA
>NZ_CP023689.1|WP_167537883.1|3340428_3340986_-|response-regulator
MGWVARRGVELGKTRTRWPVRTYSRVVPGASGRVLVVDDNKVIRQLIRVNLELEGLEVVTAADGAECLDVVHQVRPDVITLDVVMPRLDGLRTAARLRSDPRTRDLPLAIISACTQYEVDSGLDVGVDAFLAKPFEPAELVSLVRRLIERSGSGEADGCPEGRGADDAVLGGVLGAGEAAGRTGG
>NZ_CP023689.1|WP_150499776.1|3338982_3340164_-|hypothetical-protein
MTPVELSRSVLCAVRRAVDEGELAVAVPERALVTVPGPGGCGDYATNIALQLARPAGQPALRVAEILRSHLAGADGVADVVVTGPGFLNIRLGGTASVALVEEILRRGDRYGYAKGPSADFVPLSCPREVRAVVVMDAVARILRSQGAAVRTRCEAELPQEWVDVLGVRVDTVGGGSGRPGESDTVGRRGDDARPRATRHQPVPPDDLPHYALRPVPAPLDPLFLGRDAARWALLHPAEHDRPRVTDEHLVQRESNPLFRVRYAYARTRALSRNAADLGFSAEPGPVEPSTGQFTDRLTSQSPAHLTPHALQTALADHPRVLAQAAAHRAPDRLARHLVAVADAALPLPAVVLPRGAEKPSAAHRARLALAEAAGAVLAGGLTLLGIDAPEHL
>NZ_CP023689.1|WP_150499780.1|3351918_3356598_+|amino-acid-adenylation-domain-containing-protein
MTGTTGAAAGASMAERFGALSGEQRIRLMRRLVESGQLGLIPAVVPARDGEGPVRLSPAQEDLWVYESLYPGTPALNLCCAYHFDDPTDPDLLETALTLVRRNHDVLRSRIDGEPGALGVTFPPEERFRLERQDLRGTGVTIAEAFETFRRRPFDLAGEPLMRARLVTVDDRRATLMVSLHHVIADWWSFDVLQAEFAEAHRALRSDGAPMPARPRIQYADFASWQGELEASGVFEARLAFWRRYLAEPPGPLTVPGAGAGSSEEIAQIPFQVDAPTARAVRALARERGASVYVVLMAAFAVLAHRLTGADDMVLGTPTANRAAKGLERVIGYVMNAIPTRWRIRPGDSFADVLARFAADFPELMANADVPVGRIVSAVAPDRSAGRSPLFQWVFMHLTQQRSVAALREFSEPERIHTGGEHDLVGIVRDAEDGTMDGSFEIRTALFDADAVGHWTDAYLELLRRFTADPGVPLTEVGLLSEAGRTRLLELGVGPDAPESVSLPDLVARQAARTPGAPALEAGALALTYAELVDRVDRLAEAFAEHGAGAGAVVALALGRTPAMVPALLAVQRAGAAYLPVDPDYPGERIRGALEDAKPVLVVVGERGVPVDTDVPTLVLSESLELPRGEVERVPRRRGLSRSSPRPLRGSTPAYVIHTSGSTGRPKGVLVPHTGIAALAQGLVDGMALTPGTRVLQLGSPAFDISVAEMCMAFGSGGTLVVAPDGPLVGQGLAEVLTGLRIGATMLPPSVLATLPAGEYPDLRSLAVGAEACPPELVARWAVGGRRFHNAYGPTEFTVAATVSGPLIGDGTPPPIGAPLPGTRAYVLDERLRPVPPGVCGELYLAGPGVAYGYLGRAAASAERFVADPYGAPGTRMYRTGDLARRRDDGQLEYLGRSDDQVKIRGQRIEPGEIAAVLTGHPSVERAVAVVREDRPGRPRLVAYVVGGDGQGPVPDALLAYAAGRLPAAMVPADVVVLDALPLAPNGKLDRAALPAPGSRSDGAGRAPEGVREVALCALFEEVLGVERVGADDDFFRLGGDSIMAIQLAGRAAGAGLGITPRDVFTARTPASLALTARETEGLGEDAGTGRFPLTPVMRWWREQGGDASAFTQSMLFPVPAGAGPEQVEAAVRALVERHGALRMRLVDGELEIGEAVPEVTVARVEVPAGADVRELADELAAAVRLDPERGEMVRATWLDGDAERPGPLLLTVHHLAVDGVSWRLLGPELAAALAGERLPEPPGTSFARWARLLAEEAVRPGTADVESVRWEGMLGGPDARIAGGRGAGASRAVLTVELTPEVTGAALSEVTEVFHCGPDAVLLTALAAAAVRHRGNGTGLLVALEGHGREGLSRPADVSRTVGWFTTQYPVRLDAGTALGADFWQPARDAAGEALKQVKERLRSVPSGGLSWGLLRHLNADTAPKLALLPVPDLRFNYLGRFSGGDTADGELLGMAAEALPLGHAVEIDAVVLERAAGRPCLSAAFSYARGVLGEDEVLALARLWCEAIEVLVEHARRDGSGGHTSSDFPLVDLSSDQLALLEGDLDLGPGLDDEGDD
>NZ_CP023689.1|WP_150499781.1|3356597_3360464_+|amino-acid-adenylation-domain-containing-protein
MGGRIADVLPLSPAQEGLLFHALRDPERPDPYLVQARFRIAPGITGEALRAGVAGLLERHPNLRACFRHEHVERPVQVIPRAVRLPWTEIDRTGHTRDEAAAELARLMAEDRRVRFDLARPPLLRATLVRHDEGAELLLTLHHILLDGWSLPLLARDLEALTAQGGELPPAVPFKQYLVWLKGQDHDRAEAAWQAALGGLTRPVPPAQVGPDAPEDTVDVELTPELTAAVTRRAADAGVTVNTVAQTAWALVLARTTGADDLVFGAVVSGRPHDLPGVERMVGLFINTLPVRIALRAGEGVDELLARVQSEQLRLAPYHHVRLSQVQRAAGAGELFDTVLAFENFPRAEGPAPAVELIGTRDATHYPVTIAVVAGERMLLRVSCRGGVPAAAVGARLVRAFEALTSAHGTPADRLDVLPREERRQLLAQADGPTRAPSGALSIPGRFAEQVARTPDAPAVESDGEVLTYGRLDAASDALAGRLREAGVRPGDTVALPLPRSVATVVAQLAVLKAGGCCLPLDPGAPAARLAALVGAAGAQVAVADTDVQLPSGIRLLETSGRESAATPPLSVPPESAAYVMYTSGSTGEPKGIVTPHRAVVELASDGRFSGGAHERVLLHSPHTFDAATYETWVPLLNGGTVVLAPPGPVTPDLLKRLLPEGRVTGLWLTAELLRTVAEIAPEVLGGVREVWAGGDVLDAEAVRRVRERCPGTRVVNGYGPTETTVFATAHPVTGAIGACVPIGRPLDNSRTHVLDRLLRPVPAGAVGELYIAGSGLAHGYLNRPGQTAERFVADPYGPPGTRMYRTGDLVRRFPGGELEFVGRSDDQVKVRGFRIEPGEVEAALAACPGVERAVVAARPGPGGGKRLVAHVVGGDLDLVREHAARTLPAHLMPSAWARLDSVPLTGHGKVDRAALPEPEPERARSGHGRIARPGHEQRLCALFAQALGVDAIGPDGDFFAHGGHSLLALRLTASIHAELGTRVSPATLFEAPTPAALAARLTADRTEEDAYAPLLTLRREGDLPPLFCLHPGLGLGWAYAALLPHLAPGRPVYALQTPVLHGGQLPATLGELAESCLPVVRAVRPHGPYLLLGRSFGGPLAHELAVRLRAAGEEVALVAVVDAMPKPPEVARVPLEAVVVEQAALGNLLRNALPGVPAGPGPLDRAEVVARVQAHSALLAGLDRPRIGALVGAMERYIEMARAWRPSPYDGRVTLFSATRAAEATTGEKSAAWRACAAAVDVHELDCEHSDVLTPGPVGEIAAVVENVLADLAEPAGDRTGGRSTGR
>NZ_CP023689.1|WP_150499782.1|3360460_3363754_+|amino-acid-adenylation-domain-containing-protein
MTADDIGTVGEYDEALGEPEEYEFPTSDAQARLLVLDHMDPGAATYHVPAAFVVRGPFDAAAFGRALDTLVARHESLRTVFRTGPDGVPLQLVSAAGRVEPRAEHDVPVAEAEARMRAEAARPFDVTAGPLLRCTLYAMADGSHRVLLVAHHLVCDGWSLGVLLRELSAGYENETKGLPHSPPELPLQFPDFAAWQRERQAAGEYGGSVAHWAERLRGAPETVALPLDRPRGAVRTAAGGTERFTVPARVRERIARTARTRGGTPFMAVFAAYAAFVSRLSGSEDLVIGFPVSGRDRPELQDMVGMLTNTLALRVDLSGDPSYHDLIDRLRTTLLDSQPYQDAPFEAVVDEVAPAREISHDPVVQVVFGYDDDTELTLRLAGAEVDRVHVGLDTAKFDFHLQVERWGEDLAAYLIFRTALFDTETVRRWVRCFETLLEGLLAHPDAPLSTIDILPAPEKERLLTAPQRGAGNCATSHDEPAAASQSIAALPKAHRVPTLVAHQATTRPEATALVCGDLHLTYAELLARADRLAASLQTQGVRRGDRVGLLLPRGADMGIAALAVLRAGGAYVPLDPAHPPARLAYMITNSGTSLLLTAAETTGVAGIDVPELRVDQDPEPAPPALTPVECAPDDLAYVLYTSGSTGVPKGVAVEHRALFNLAVNVRPVFPVNEADRVLQFVSFGFDVAVSDLFFPWVAGAELHIAHEDERLGEALQARLRDSRITYVFLPPSAAMTLPRAPGALPDLRTLAVGGEACPAELVERLGEEGRRIVNAYGPSEATVYSTTADLRPGEPVVIGHAVPGSRAYVLDGRLRPAPVGVTGELYVAGATLARGYFGRPGMTAERFVADPYGPPGARMYRTGDLCRIDARGVLHYLGRSDSQVKLRGYRIELGEIEAVLAGHPGVTVAAAAVRGEGAEQRLVAYVVGQDPAPSDEALRSLLAGRLPGYMVPEVFVRLPELPLNRSGKIDRSRLPEPPSSRPELSGSYTAPDSAAERRVARVWQQVLTLDRVGIHDNFFDLGGNSVRLLAVLAALQEHPEYRDLTLIDLFRHPTVAAVAAHLDRAAEQAAPHEEAARRGSDRRAALHKLRSRKGTTR
>NZ_CP023689.1|WP_150499783.1|3363750_3365805_+|hypothetical-protein
MTTEEAAQHDLEPAVAVVGMSGRFPGAPDLDAYWANLRDGVCSLSAFTEKELLADGADPAELRNPAYVPAQGHLADADRFEAELFGFNRTEAAALDPQHRVLLETAWSALEDAGYAPLNAPSRTGVYVGGSPTEHALAAGTDPALAASIGALQVRILTDREFLAPWISYRLGLDGPSMTVQTACSTSLTAVHLAVQALLLGECDTALAGGVAIGTVRRQGYVHYQGGIFSPDGRCRPFDEKAAGTVPGSGVGVLVLRRLEDALADGDPVRAVIRGTAVTNDGAGKVGFTAPGVDQQTAAITEAWAAAGLEPSAAQYVEAHGTGTELGDRIELEAASAAFAAGDRSAPAGGAGIGLGSVKSNIGHADAAAGAAALIKTVLMLEHATLAPTVDVTSPVAALADSPLRLVTETRQWQRRPDLPRLAGVTSVGIGGTNVHVVVQEAPARGPRAEAGARPTVLPLSARTEHQLGLVASRLAARLREVDAPALADVAHTLRTGRVGMPVRAYVVAAGTREASDKLMALAEGHPDSVRDPAGEAWLRGEEMTWPALDGEVRRVRLPAYPFAGESHGALTLRGPAAHPPAEAAAPAPGSELEAEVAELVVEALDLDGPAGLEKTYFEAGGDSLTAVHLAGRLRDELDIDVPIQLFLEPITLKEMTIRIVEIKEGGGADGALDALLAEFEAES
>NZ_CP023689.1|WP_150499784.1|3365801_3366554_+|alpha/beta-fold-hydrolase
MTAPDIHTRWLRGVSAPAAKVRLVCFPHAGGAAGTFHGWAALTPPEIEVLSVQYPGRQDRLSEPCPATMDELADAITSALLAELTDDLPLALFGHSMGSSVAYEVARRLEGIPGRSLTRLIVSGRTRPRLAQELAPRPVPTDTDILNHVRRLDPEGAALYENPMLRGVIMPALRGDFGLLAAYRPAHLHRLGVPVTACGGDSDPACPVEDLSAWSDVTTEDLDVRVFEGNHFYLTPRQEELVGFLTERLL
>NZ_CP023689.1|WP_150499785.1|3366569_3367589_-|Ku-protein
MRSIWNGAISFGLVSIPIKVVNATESHSISFRQIHTEDGGRIRYRKFCELEDREVGQAEIGKGYEDADGSIIPITDEDLAQLPIPTAKTIEIVAFVPGDRIDPLQMDAAYYLAASGAPAAKPYTLLREALKRSNKVAIAKFALRGRERLGMLRVVGDAIAMHGLLWPDEVRAPEGVAPDAGVTVRDKELDLADALMDTLGEVDLDDLHDEYREAVEEVIAAKAAGEALPAAPEPATGGKVLDLMAALESSVRAAKESRGEEPEEAEVRRLPQRKSARAAPKQTAGKKSTSASKKTAAKKTTASAKKSTSKSAQGGKKTAAKSTTKKSAAKKTTSRKRTA
>NZ_CP023689.1|WP_150499786.1|3367640_3368522_+|ATP-dependent-DNA-ligase
MTPITEVEGRRLALSNLEKVLYPATGFTKGEVLHYYATTADVLLPHLRDRPVSFLRYPDGPDGQVFFTKNVPPGTPEWVTTAEVPRVEGPARMVFVQDLASLMWAANLVTEFHTPQWVIDAPGEADRLVFDLDPGSPATVVECCEVALWLRERLAADGIEAYAKTSGSKGLHLAATIRPVSSERATEYAKDLAVEAEKALPRLAIHRMTKSLRPGKVFVDWSQNAARKTTATPYTLRARREPTVSTPVTWEEVVDCRSPDALTFSAPDLAPRLQDYGDLLAPLLDADRAGTLP
>NZ_CP023689.1|WP_107902849.1|3368643_3369450_-|NERD-domain-containing-protein
MNGLRVIPTWRHGQERLYVCLTDGRNLAWYDREAGRINLLSDASREDVLEALGPFITGSVTVGPPPVPTPAELAGLTLHPDDDLAPNRPGEALLIALDRDPGPSRRLRPDPRRRALTAEQTVGEALDRLDGAGWHALHSVPLPGGDRIHHLLIGPGGLFALHTLYARKAKVTVADPVVALGRRETYPLLRRVRSDADRASYALTAEVRPVLVLVAPAAVAITASVREVRVLRDTEVDGLRRSGGVLKPADVEALHAMARDRRVWLAAG
>NZ_CP023689.1|WP_125530012.1|3369563_3370070_+|protein-phosphatase
MRTRRKQPDVPAPDSPWSEIVPGLWMGGHEFRGRSGQLEFAVVRDEFDLVQTLLRLPGHGPDPGVEHHVWPIPDGPLDGTQLAGVIRLAEAACEAVDAGRRVLVRCYHGYNRSGLVVAHALVRRNHSAEQAIRLIRSRRSPWALHNELFVDYLRAGLSTARLLEELAE
>NZ_CP023689.1|WP_150499787.1|3370161_3370911_+|hypothetical-protein
MPRSRHTRIVALSALVALLLAAATACGDAGELQGAGPTETAVSPDKLWPRLTPASRPAYEIGEVNREAVKGVMLPGDDIRDVNPVAVVRKEMDKSPGDYEGQNAQYRETGRLMAQCGGGAGHGKCPVLRPYYRDLTGDGRPELTLGFRLLPGKTTAVRVYTVEKHRLMQVMSWDDAISSVELAGRSVIIRSPSEVAGYEYRLQWTWDADEKAMLLTHDEMLRTGHRKKSPHPSPSPSGSPSLTPSASTP

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Crispr_ID: NZ_CP023689_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_2

3811582-3811683

Orphan

Consensus_repeat	Method
GTCGCGCAGTTCCCCGCGCCCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_2

>merge|NZ_CP023689|2|3811582-3811683|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCTAAAGGCAGGGGGTTGCAGTGGCCCTGCGCCAAGCCGTGACCGCAACCGTCACAACCGTCGCGCAGTTCCCCGCGCCCCT

>NZ_CP023689|2|2|3811582-3811683|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCT	AAAGGCAGGGGGTTGCAGTGGCCCTGCGCCAAGCCGTGACCGCAACCGTCACAACC
GTCGCGCAGTTCCCCGCGCCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150500076.1\|3816977_3817877_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|365919
NZ_CP023689.1\|WP_150500078.1\|3818767_3819124_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107903760.1\|3818010_3818697_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|223645
NZ_CP023689.1\|WP_107903748.1\|3803222_3803843_+\|septum-formation-inhibitor-Maf	unknown	unknown	gnl\|CDD\|178901
NZ_CP023689.1\|WP_150500080.1\|3820989_3822561_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP023689.1\|WP_150500072.1\|3814577_3815543_+\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188646
NZ_CP023689.1\|WP_107903750.1\|3803811_3804342_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_037867721.1\|3820315_3820993_+\|two-component-system-response-regulator-AfsQ1	unknown	unknown	gnl\|CDD\|223816
NZ_CP023689.1\|WP_093747095.1\|3819301_3820048_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP023689.1\|WP_125530042.1\|3806772_3807321_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP023689.1\|WP_030956459.1\|3810692_3811517_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_CP023689.1\|WP_150500068.1\|3811918_3813550_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_CP023689.1\|WP_150500066.1\|3804703_3806476_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
NZ_CP023689.1\|WP_125529642.1\|3808578_3810027_-\|NAD(P)H-quinone-dehydrogenase	unknown	unknown	gnl\|CDD\|236112
NZ_CP023689.1\|WP_150500074.1\|3815548_3816985_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143429
NZ_CP023689.1\|WP_107903743.1\|3801605_3801815_+\|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl\|CDD\|379386
NZ_CP023689.1\|WP_107905243.1\|3810123_3810561_+\|gamma-glutamylcyclotransferase	unknown	unknown	gnl\|CDD\|372719
NZ_CP023689.1\|WP_150500070.1\|3813689_3814376_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP023689.1\|WP_150500064.1\|3801811_3802942_-\|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|238868
NZ_CP023689.1\|WP_093747101.1\|3807443_3808400_-\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150500076.1\|3816977_3817877_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	1.46522e-42
NZ_CP023689.1\|WP_150500080.1\|3820989_3822561_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.17169e-52
NZ_CP023689.1\|WP_107903760.1\|3818010_3818697_+\|uridine-kinase	gnl\|CDD\|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	1.57579e-13
NZ_CP023689.1\|WP_107903748.1\|3803222_3803843_+\|septum-formation-inhibitor-Maf	gnl\|CDD\|178901	PRK00148, PRK00148, Maf-like protein; Reviewed.	1.11333e-95
NZ_CP023689.1\|WP_150500072.1\|3814577_3815543_+\|deoxyribose-phosphate-aldolase	gnl\|CDD\|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	3.42436e-75
NZ_CP023689.1\|WP_037867721.1\|3820315_3820993_+\|two-component-system-response-regulator-AfsQ1	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.57745e-80
NZ_CP023689.1\|WP_093747095.1\|3819301_3820048_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	4.80536e-65
NZ_CP023689.1\|WP_125530042.1\|3806772_3807321_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.68968e-11
NZ_CP023689.1\|WP_030956459.1\|3810692_3811517_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	8.22671e-136
NZ_CP023689.1\|WP_150500068.1\|3811918_3813550_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_CP023689.1\|WP_150500066.1\|3804703_3806476_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
NZ_CP023689.1\|WP_125529642.1\|3808578_3810027_-\|NAD(P)H-quinone-dehydrogenase	gnl\|CDD\|236112	PRK07845, PRK07845, flavoprotein disulfide reductase; Reviewed.	0
NZ_CP023689.1\|WP_150500074.1\|3815548_3816985_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143429	cd07111, ALDH_F16, Aldehyde dehydrogenase family 16A1-like. Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.	0
NZ_CP023689.1\|WP_107903743.1\|3801605_3801815_+\|acyl-CoA-carboxylase-subunit-epsilon	gnl\|CDD\|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	1.41783e-09
NZ_CP023689.1\|WP_107905243.1\|3810123_3810561_+\|gamma-glutamylcyclotransferase	gnl\|CDD\|372719	pfam13772, AIG2_2, AIG2-like family. This family is found in bacteria and metazoa.	3.87517e-27
NZ_CP023689.1\|WP_150500070.1\|3813689_3814376_-\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	0.000109019
NZ_CP023689.1\|WP_150500064.1\|3801811_3802942_-\|SGNH/GDSL-hydrolase-family-protein	gnl\|CDD\|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	4.11665e-84
NZ_CP023689.1\|WP_093747101.1\|3807443_3808400_-\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.9381e-81

>NZ_CP023689.1|WP_030956459.1|3810692_3811517_+|purine-nucleoside-phosphorylase
MNASLLPDDIQGDPHAAADAAAARLRELTGAETHDVALVMGSGWAPAVDALGAPEAEFQVTELPGFPPPAVEGHGGKVRSYRIGNKRALVFLGRTHYYEGRGVAAVSHGVRTAVAAGCKTIVLTNGCGGLREGMRPGQPVLISDHINLTATSPIIGANFVDLTDLYSPRLRALCKEIDPTLEEGVYAQFPGPHYETPAEIRMARVIGADLVGMSTVLEAIAAREAGAEVLGISLVTNLAAGMTGEPLNHEEVLQAGRDSATQMGSLLAQVLGRL
>NZ_CP023689.1|WP_107905243.1|3810123_3810561_+|gamma-glutamylcyclotransferase
MSLYAAYAGNLDARLMTRRAPHSPLRATGWLNGWRLTFGGEQLGWEGALATLVEDPMEQVFVALYDIAPMDEDSLDRWEGVGLGIYRRLRVRVHTLEGEEPAWTYVLNAYEGGLPSARYLGEVADAAESAGAPHDYVMELRKRPC
>NZ_CP023689.1|WP_125529642.1|3808578_3810027_-|NAD(P)H-quinone-dehydrogenase
MEYVTRIVIIGGGPGGYEAALVAAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPHIDTPARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVMRGRGRLEGMQGLDGSRKVVVRAADGTEETLVADAVLIATGGHPRELPDAQPDGERILNWTQVYDLNELPEELIVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMARSRAAAAKRVGDRVEVTLADGRVISGTHCLMAVGAIPNSEGMGLEEAGVKLRDSGHIWTDKVSRTTAPGVYAAGDVTGVFALASVAAMQGRIAMYHFLGDAVAPLNLKTVSSNVFTDPEIATVGYSQADVDAGKIDARVVKLPLLRNPRAKMQGIRDGFVKIFCRPGTGIVVGGVVVSPRASELIHPISIAVDNNLTVEQIANAFTVYPSLSGSIAEVARQLHTRKSGGEL
>NZ_CP023689.1|WP_093747101.1|3807443_3808400_-|DeoR/GlpR-transcriptional-regulator
MFAAERRQLILEMVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFTRESGFPQKSHLATAEKTAIADLAANFVEEGEAIVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVSRAFLSGSGLTAERGLSTSNMLSASVDRALVQAAAEVVVLADHTKLGTDTMFQTVPTDVITRLVTDEPPAHDDRAHTELQALADQGVQIAVAGASGASGGDEVPARRQQRALPGPRRGPSGGGPGLRPAGAAVLGEQGAERERARVADLRRR
>NZ_CP023689.1|WP_125530042.1|3806772_3807321_+|TetR/AcrR-family-transcriptional-regulator
MRADARRNHERLLTEARSAFAEHGTDASLEDVARRAGVGIGTLYRHFPNRDALLSAVFEEAAGDLLARSRELLRSPEPCAALVTWLREMVTHAGEYRGLARSLMSVSDDDTSALARCSGPIRQAGGALLSRAQEAGTVRPDVAVTDLLQLTHAIALAAEQTPDDPDLADRLLHLTLRGLKAP
>NZ_CP023689.1|WP_150500066.1|3804703_3806476_+|ATP-grasp-domain-containing-protein
MRKVLIANRGEIAVRVARACRDAGIASVAVYADPDRDALHVRAADEAFALGGDTPATSYLDIGKVLTAARESGADAIHPGYGFLSENADFAQAVLDADLIWIGPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVAGADEVVAFAETHGLPIAIKAAFGGGGRGLKVARTLDEVPELYESAVREAVAAFGRGECFVERYLDKPRHVETQCLADTHGNVVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQVAELYSSSKAILKEAGYVGAGTVEFLVGADGTISFLEVNTRLQVEHPVTEEVAGIDLVREMFRIADGEALGYDDPPLRGHSFEFRINGEDPGRGFLPAPGTVTAFAPPSGPGVRLDAGVESGSVIGPAWDSLLAKLIVTGATREQALQRASRALEEFQVEGMATAIPFHRAVVKDPAFAPELTGSTDPFTVHTRWIETEFVNDIKPFAAPADTDADEDTGRETVVVEVGGKRLEVSLPASLGMTLARTGLAAGAKPKRRAAKKSGPVASGDTLASPMQGTIVKVAVEEGQEVKEGDLVVVLEAMKMEQPLNAHRSGTIKGLSAEVGASLTSGAAICEIKD
>NZ_CP023689.1|WP_107903750.1|3803811_3804342_-|hypothetical-protein
MVRRPVAWLVAVVLFVEAFGIAALNWFLGVVVDRQDMSLAGLDPDVMSVSSKVGGLVFGGYFALCGLVALLVALRDRAPAGLGRILLISAAVVHGLLGAFAWGLVGWTAFVFMIVVLGLIVLLLMTYDGQSAPGRPADAAPDGGKGGDGSPVDGSPAGSSPAGGSPVTPPPAPTTP
>NZ_CP023689.1|WP_107903748.1|3803222_3803843_+|septum-formation-inhibitor-Maf
MTDQPRRRLVLASQSPARLNLLRQAGLAPEVIVSGVDEDAVSAPTPAELALALAEAKASVVAARPEVKGAIVIGCDSVLDLDGEALGKPADAEEATARWKSMRGRAGTLQTGHCVYDTLSGRYTSATASTVVRFGEPTDEEIAAYVASGEPLYVAGAFTLDGRSAPFIDGIDGDHGNVIGISLPLVRRLLAQLGIGITELWEPAEG
>NZ_CP023689.1|WP_150500064.1|3801811_3802942_-|SGNH/GDSL-hydrolase-family-protein
MFTASWTASPQRPSEGFTPNWSREGFWRQSLRQVVRLSAGGGLLRVRLSNAYGESPVRVAGASVGRAGEGAAVRPGSLTPLTFGGAAGVAIPARGEVVSDAVRLAVAAGESVAVTLYFDAATGPATFHAQAFASGHRGEGDLSQASGGEGFDAVSESWYFLSAVETDAGRTDGVALLGDSITDGFGSTVGADRRWSDALAKRTGRPVLNAGIGGNLLLNDSAWYGDGGVRRLRRDVLGLPGVDTLVVLLGLNDIGFSETDEQPTYKPAPVVEAAELIAGHRELLRQGRAAGLRVIGGTLLPFGGSDHWGEHAAKVSHELNEWIRCAGEYDAVVDLNRALADPEDPDRLRPAYDFGDHLHPNDAGYEVMAEVLAIAL
>NZ_CP023689.1|WP_107903743.1|3801605_3801815_+|acyl-CoA-carboxylase-subunit-epsilon
MNIKVLRGNPTPEELAAALAVVRARAAAEAAIPPGAPKPRDGWSDPSRIARRRLPQPGPATWARTYWPG
>NZ_CP023689.1|WP_150500068.1|3811918_3813550_+|phospho-sugar-mutase
MHDDLITRAKAWLEEDPDPETRAELAKLIDAADVTELAPRFSGTLQFGTAGLRGELGAGPMRMNRTVVIRAAAGLAAYLKSQGHTDGLVVIGYDARHKSEDFARDTAAVMTGAGLRAAVLPRPLPTPVLAYAIRHLGAAAGVEVTASHNPPRDNGYKVYLGDGSQIVPPADADIAAEIDAVRSLNDVPRPDSGWETLDDSVLDAYLARTDEVLAAGSPRTARTVYTAMHGVGKDVLLAAFERAGFPAPALVAEQADPDPDFPTVAFPNPEEPGAMDLAFAKARETDPDLVIANDPDADRCAVAVKEDAEWRMLRGDEVGSLLAAHLVGRGARGTFAESIVSSSLLGRIAEKAGLPYEETLTGFKWIARVDGLRYGYEEALGYCVDPEGVRDKDGITAALLITELASALKEEGRTLLDLLDDLAVEHGLHATDQLSVRVEDLSVIADAMRRLREQPPTELAGLAITRAEDLTRGTETLPPTDGLRYTLEGARVIVRPSGTEPKLKCYLEVVVPVAKHADLPAARAEAAALLATIKRDLSTAAGI
>NZ_CP023689.1|WP_150500070.1|3813689_3814376_-|PH-domain-containing-protein
MTTPEHPSPSPDPTSKDRVYRSPMGIVGGVALLVIVLWLGFDALLRGEGRTQWLALAAIILLVPLVIAFTLRPAVHANEDRLRIRNPLRVIVLPWGQVAALRSSYSNEVVAKSGTKFQLWAVPVSLRARKKAARRSARAASGRGDRGGRTGGGAGFGGLGFGAPRGDVDSDGPMRAETDKVMDDLRELLEQGENSESAQGEVTVRWAYEVAGPVVAGAVLLVILLAIG
>NZ_CP023689.1|WP_150500072.1|3814577_3815543_+|deoxyribose-phosphate-aldolase
MTMPTNASAAAHALTDVTASDSTLRRFLHGLPGVDAVGLEGRAASLGTRSIKTTAKAYAIDLAISMVDLTTLEGADTPGKVRALGAKAVHPDPTDRTTPSTAAVCVYPDMVATAKAAVAGSTVKVASVATAFPAGRAPLGVKLADVREAVAAGADEIDMVIDRGAFLAGNYMKVYDEIVAVKEASGAARLKVIFETGELSTYDNIRRASWLGMLGGADFIKTSTGKVAVNATPANTLLMLEAVRDFRAQTGIQVGVKPAGGIRTSKDAIKFLVLVNETAGEDWLDNHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD
>NZ_CP023689.1|WP_150500074.1|3815548_3816985_+|aldehyde-dehydrogenase-family-protein
MASVFEYAPAPESRSIVDIAPSYGLFIDGEFVEAADGKVFKTVSPSTEEVLAEIAQAGEADVDRAVQAARKAFEKWSALPGSERAKYLFRIARIIQERSRELAVLETLDNGKPIKETRDADLPLVAAHFFYYAGWADKLDHAGFGANPQPLGVAGQVIPWNFPLLMLAWKIAPALATGNTVVLKPAETTPLSALFFADICRQAGLPKGVVNILPGYGDAGAAVVAHPDVNKVAFTGSTAVGKEIARTIAGTRKKVTLELGGKGANIVFDDAPIDQAVEGIVNGIFFNQGQVCCAGSRLLVQESVEEELLESLKRRLSTLRLGDPLDKNTDIGAINSEEQLTRITSLVEAGEAEGAERWSPACDIPESGYWFAPTLFTNVTQAHRIARDEIFGPVLSVLTFRTPDEAVAKANNTPYGLSAGIWTEKGSRILAVANKLRAGVVWSNTFNKFDPTSPFGGYKESGFGREGGRHGLEAYLDV
>NZ_CP023689.1|WP_150500076.1|3816977_3817877_+|aldehyde-dehydrogenase-family-protein
MSDKSEQQRLSVFKTYKLYVGGKFPRSESGRVYEVTDSKGNWLANVPLSSRKDARDAVVAARKAFGGWSGATAYNRGQILYRIAEMLEGRREQYVREVADAEGLSKSKAAAQVDAAIDRWVWYAGWTDKIAQVVGGGNPVAGPFFNLSSPEPTGVVAIVAPQESSFLGLVSVLAPVIATGNTAIVVASEKSPLPALSLGEVLATSDLPGGVVNVLSGRTAEIATPLAAHQDVNAIDLAGAGEDLAKELEIAAADNLKRVLRPQSVDHTATPGIDRMTAFLETKTVWHPTGSLGASGSSY
>NZ_CP023689.1|WP_107903760.1|3818010_3818697_+|uridine-kinase
MVRRVVHRPVDASHWCPVSSPSPIPTRVVLLCGPSGSGKSLLAARSGLPVLRLDDFYKEGDDPTLPLVPGSSDIDWDHPDSWDADTAVAAITELCRTGRTDVPLYDISLSARTGAESVDIGRTPLFIAEGIFAAEIVNRCRELGVLADALCLSRGPMRTFRRRFLRDLKEGRKSVPFLLRRGWRLMRLERSIVAHQTSLGAYACDRDEALGRLTAAAAGRCPATAPAA
>NZ_CP023689.1|WP_150500078.1|3818767_3819124_+|hypothetical-protein
MTGAPLTVRRVLPAVLLALAATGCGEGDATEPDGTAAASCAYMVTYADRTYLGTAGTDFTVGKKLGTATVPECDDTPNDPEGAVPEGKVTAYAVEGEDPAVAIAVGDTPAEATLMKVR
>NZ_CP023689.1|WP_093747095.1|3819301_3820048_-|SigE-family-RNA-polymerase-sigma-factor
MNTLHGTSTSAVITRLHDVNGGRGSEKSGAVSGRGCARGTGRQHTAYMTVVDGFTGEPHGGSAYREDSGERRRSLSEAEFTAYVQERRASLYATAYHLTGDRFEAEDLLQSALFSTYKAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETPGDTDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIADILDISVGTVKSSIWRSLRRLREDEVLSFGRDEEDAFGELVA
>NZ_CP023689.1|WP_037867721.1|3820315_3820993_+|two-component-system-response-regulator-AfsQ1
MPSLLLIEDDDAIRTALELSLTRQGHRVATAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARNDDIDIVVGLESGADDYIVKPVQGRVLDARIRAVLRRGERESNDAAAFGSLVIDRAAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDAPQ
>NZ_CP023689.1|WP_150500080.1|3820989_3822561_+|HAMP-domain-containing-protein
MTEAQGGFRGWFAARKGVWSRLRFTSLRLRLVVVFGLVALTAAVSASGIAYWLNREAVLTRTQDAVLRDFEQEMQNRAGLLPEEPTQDELQHTAGQMANSSQRFSVLLVAQDAAGAPAYGSSGGLDGFTLADVPKSLRTAVNEKQEVDSSNKAEYHLYWQRIVEDDTPYLIAGTKVNGGGPTGYMLKSLEQEAKDLNSLAWSLGIATGLALIGSALLAQAAATTVLKPVQRLGVAARRLGEGKLDTRLRVSGTDELADLSRTFNNAAAALEKRVADMASRDESSRRFVADMSHELRTPLTAITAVTEVLEEELEMESGSMDPMIEPAVRLVVSETRRLNDLVENLMEVTRFDAGTARLVLDHVDIADQITACIDARAWLDAVDLDAERGIMVRLDPRRLDVILANLIGNALKHGGSPVRVAVRVTDDEIVIAVRDHGPGIPEDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSPEGGAIFTLRLPRETSDAVASGDENPQHNPPKGDA

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Crispr_ID: NZ_CP023689_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_3

3823201-3823303

Orphan

Consensus_repeat	Method
GTCGCGCAGTTCCTCGCGCCCCTA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_3

>merge|NZ_CP023689|3|3823201-3823303|CRISPRCasFinder
GTCGCGCAGTTCCTCGCGCCCCTAAAAGAAGGGCGTTGCAGTGGGCCTGCGCCGAGACGTGACCGTGGGCCTAACAACCGTCGCGCAGTTCCCCGCGCCCCTA

>NZ_CP023689|3|3|3823201-3823303|CRISPRCasFinder
GTCGCGCAGTTCCTCGCGCCCCTA	AAAGAAGGGCGTTGCAGTGGGCCTGCGCCGAGACGTGACCGTGGGCCTAACAACC
GTCGCGCAGTTCCCCGCGCCCCTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_107903774.1\|3826474_3827236_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|225496
NZ_CP023689.1\|WP_150500076.1\|3816977_3817877_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|365919
NZ_CP023689.1\|WP_150500080.1\|3820989_3822561_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP023689.1\|WP_107903760.1\|3818010_3818697_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|223645
NZ_CP023689.1\|WP_150500092.1\|3830624_3831011_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|379202
NZ_CP023689.1\|WP_150500072.1\|3814577_3815543_+\|deoxyribose-phosphate-aldolase	unknown	unknown	gnl\|CDD\|188646
NZ_CP023689.1\|WP_150500088.1\|3828279_3829548_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340882
NZ_CP023689.1\|WP_150500082.1\|3822560_3823166_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_037867721.1\|3820315_3820993_+\|two-component-system-response-regulator-AfsQ1	unknown	unknown	gnl\|CDD\|223816
NZ_CP023689.1\|WP_093747095.1\|3819301_3820048_-\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP023689.1\|WP_150500078.1\|3818767_3819124_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150500074.1\|3815548_3816985_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143429
NZ_CP023689.1\|WP_150500094.1\|3831197_3832118_+\|AEC-family-transporter	unknown	unknown	gnl\|CDD\|223751
NZ_CP023689.1\|WP_126899733.1\|3827262_3828216_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
NZ_CP023689.1\|WP_093747093.1\|3824240_3824441_+\|PspC-domain-containing-protein	unknown	unknown	gnl\|CDD\|377200
NZ_CP023689.1\|WP_150500090.1\|3829721_3830741_+\|RNA-polymerase-subunit-sigma-70	unknown	unknown	gnl\|CDD\|236196
NZ_CP023689.1\|WP_150500070.1\|3813689_3814376_-\|PH-domain-containing-protein	unknown	unknown	gnl\|CDD\|371225
NZ_CP023689.1\|WP_150500084.1\|3823580_3824132_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_CP023689.1\|WP_107903770.1\|3824582_3825005_-\|ATP-binding-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150500086.1\|3825143_3826340_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150500076.1\|3816977_3817877_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|365919	pfam00171, Aldedh, Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	1.46522e-42
NZ_CP023689.1\|WP_150500080.1\|3820989_3822561_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.17169e-52
NZ_CP023689.1\|WP_107903760.1\|3818010_3818697_+\|uridine-kinase	gnl\|CDD\|223645	COG0572, Udk, Uridine kinase [Nucleotide transport and metabolism].	1.57579e-13
NZ_CP023689.1\|WP_150500092.1\|3830624_3831011_-\|STAS-domain-containing-protein	gnl\|CDD\|379202	pfam13466, STAS_2, STAS domain. The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.	4.33156e-10
NZ_CP023689.1\|WP_150500072.1\|3814577_3815543_+\|deoxyribose-phosphate-aldolase	gnl\|CDD\|188646	cd00959, DeoC, 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in catalyzing the aldol reaction between two aldehydes, and its broad substrate specificity confers considerable utility as a biocatalyst, offering an environmentally benign alternative to chiral transition metal catalysis of the asymmetric aldol reaction.	3.42436e-75
NZ_CP023689.1\|WP_150500088.1\|3828279_3829548_+\|MFS-transporter	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.80802e-68
NZ_CP023689.1\|WP_126899733.1\|3827262_3828216_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.66405e-89
NZ_CP023689.1\|WP_037867721.1\|3820315_3820993_+\|two-component-system-response-regulator-AfsQ1	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.57745e-80
NZ_CP023689.1\|WP_093747095.1\|3819301_3820048_-\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	4.80536e-65
NZ_CP023689.1\|WP_150500074.1\|3815548_3816985_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143429	cd07111, ALDH_F16, Aldehyde dehydrogenase family 16A1-like. Uncharacterized aldehyde dehydrogenase family 16 member A1 (ALDH16A1) and other related sequences are present in this CD. The active site cysteine and glutamate residues are not conserved in the human ALDH16A1 protein sequence.	0
NZ_CP023689.1\|WP_150500094.1\|3831197_3832118_+\|AEC-family-transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	1.27289e-41
NZ_CP023689.1\|WP_093747093.1\|3824240_3824441_+\|PspC-domain-containing-protein	gnl\|CDD\|377200	pfam04024, PspC, PspC domain. This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	7.58806e-20
NZ_CP023689.1\|WP_150500090.1\|3829721_3830741_+\|RNA-polymerase-subunit-sigma-70	gnl\|CDD\|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	0
NZ_CP023689.1\|WP_150500070.1\|3813689_3814376_-\|PH-domain-containing-protein	gnl\|CDD\|371225	pfam10756, bPH_6, Bacterial PH domain. This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales. Although several members are annotated as RbiX homologs, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	0.000109019
NZ_CP023689.1\|WP_150500084.1\|3823580_3824132_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	6.47724e-22
NZ_CP023689.1\|WP_107903774.1\|3826474_3827236_+\|alpha/beta-hydrolase	gnl\|CDD\|225496	COG2945, COG2945, Predicted hydrolase of the alpha/beta superfamily [General function prediction only].	0.000356521
NZ_CP023689.1\|WP_150500086.1\|3825143_3826340_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	1.40549e-155

>NZ_CP023689.1|WP_150500082.1|3822560_3823166_+|hypothetical-protein
MTKRRLLTLTTLSAALLTGCGIRSTEVPTDFGPAPSRVHCSLSEPNISTQAERGLPVQVFLLCGSQLVAVDRTVRVPDGTADSARRVLVAQGLLDELEATPSATEKEAGYTTDVRGAMGVTGPRPADPDETLRLSTPPDDLTSYALAQIVCTFSDSSAAEGDGSVILGGPTRETPRRYECTNEVRTRPGSNEPPSTEVTDG
>NZ_CP023689.1|WP_150500080.1|3820989_3822561_+|HAMP-domain-containing-protein
MTEAQGGFRGWFAARKGVWSRLRFTSLRLRLVVVFGLVALTAAVSASGIAYWLNREAVLTRTQDAVLRDFEQEMQNRAGLLPEEPTQDELQHTAGQMANSSQRFSVLLVAQDAAGAPAYGSSGGLDGFTLADVPKSLRTAVNEKQEVDSSNKAEYHLYWQRIVEDDTPYLIAGTKVNGGGPTGYMLKSLEQEAKDLNSLAWSLGIATGLALIGSALLAQAAATTVLKPVQRLGVAARRLGEGKLDTRLRVSGTDELADLSRTFNNAAAALEKRVADMASRDESSRRFVADMSHELRTPLTAITAVTEVLEEELEMESGSMDPMIEPAVRLVVSETRRLNDLVENLMEVTRFDAGTARLVLDHVDIADQITACIDARAWLDAVDLDAERGIMVRLDPRRLDVILANLIGNALKHGGSPVRVAVRVTDDEIVIAVRDHGPGIPEDVLPHVFDRFYKASASRPRSEGSGLGLSIALENAHIHGGEITAANSPEGGAIFTLRLPRETSDAVASGDENPQHNPPKGDA
>NZ_CP023689.1|WP_037867721.1|3820315_3820993_+|two-component-system-response-regulator-AfsQ1
MPSLLLIEDDDAIRTALELSLTRQGHRVATAATGEDGLKLLREQRPDLIVLDVMLPGIDGFEVCRRIRRTDQLPIILLTARNDDIDIVVGLESGADDYIVKPVQGRVLDARIRAVLRRGERESNDAAAFGSLVIDRAAMTVTKNGEDLQLTPTELRLLLELSRRPGQALSRQQLLRLVWEHDYLGDSRLVDACVQRLRAKVEDVPSSPTLIRTVRGVGYRLDAPQ
>NZ_CP023689.1|WP_093747095.1|3819301_3820048_-|SigE-family-RNA-polymerase-sigma-factor
MNTLHGTSTSAVITRLHDVNGGRGSEKSGAVSGRGCARGTGRQHTAYMTVVDGFTGEPHGGSAYREDSGERRRSLSEAEFTAYVQERRASLYATAYHLTGDRFEAEDLLQSALFSTYKAWDRISDKAAVGGYLRRTMTNLHISAWRRRKLNEYPTEELPETPGDTDAMRGTELRAVLWQALARLPELQRTMLVLRYYEGRTDPEIADILDISVGTVKSSIWRSLRRLREDEVLSFGRDEEDAFGELVA
>NZ_CP023689.1|WP_150500078.1|3818767_3819124_+|hypothetical-protein
MTGAPLTVRRVLPAVLLALAATGCGEGDATEPDGTAAASCAYMVTYADRTYLGTAGTDFTVGKKLGTATVPECDDTPNDPEGAVPEGKVTAYAVEGEDPAVAIAVGDTPAEATLMKVR
>NZ_CP023689.1|WP_107903760.1|3818010_3818697_+|uridine-kinase
MVRRVVHRPVDASHWCPVSSPSPIPTRVVLLCGPSGSGKSLLAARSGLPVLRLDDFYKEGDDPTLPLVPGSSDIDWDHPDSWDADTAVAAITELCRTGRTDVPLYDISLSARTGAESVDIGRTPLFIAEGIFAAEIVNRCRELGVLADALCLSRGPMRTFRRRFLRDLKEGRKSVPFLLRRGWRLMRLERSIVAHQTSLGAYACDRDEALGRLTAAAAGRCPATAPAA
>NZ_CP023689.1|WP_150500076.1|3816977_3817877_+|aldehyde-dehydrogenase-family-protein
MSDKSEQQRLSVFKTYKLYVGGKFPRSESGRVYEVTDSKGNWLANVPLSSRKDARDAVVAARKAFGGWSGATAYNRGQILYRIAEMLEGRREQYVREVADAEGLSKSKAAAQVDAAIDRWVWYAGWTDKIAQVVGGGNPVAGPFFNLSSPEPTGVVAIVAPQESSFLGLVSVLAPVIATGNTAIVVASEKSPLPALSLGEVLATSDLPGGVVNVLSGRTAEIATPLAAHQDVNAIDLAGAGEDLAKELEIAAADNLKRVLRPQSVDHTATPGIDRMTAFLETKTVWHPTGSLGASGSSY
>NZ_CP023689.1|WP_150500074.1|3815548_3816985_+|aldehyde-dehydrogenase-family-protein
MASVFEYAPAPESRSIVDIAPSYGLFIDGEFVEAADGKVFKTVSPSTEEVLAEIAQAGEADVDRAVQAARKAFEKWSALPGSERAKYLFRIARIIQERSRELAVLETLDNGKPIKETRDADLPLVAAHFFYYAGWADKLDHAGFGANPQPLGVAGQVIPWNFPLLMLAWKIAPALATGNTVVLKPAETTPLSALFFADICRQAGLPKGVVNILPGYGDAGAAVVAHPDVNKVAFTGSTAVGKEIARTIAGTRKKVTLELGGKGANIVFDDAPIDQAVEGIVNGIFFNQGQVCCAGSRLLVQESVEEELLESLKRRLSTLRLGDPLDKNTDIGAINSEEQLTRITSLVEAGEAEGAERWSPACDIPESGYWFAPTLFTNVTQAHRIARDEIFGPVLSVLTFRTPDEAVAKANNTPYGLSAGIWTEKGSRILAVANKLRAGVVWSNTFNKFDPTSPFGGYKESGFGREGGRHGLEAYLDV
>NZ_CP023689.1|WP_150500072.1|3814577_3815543_+|deoxyribose-phosphate-aldolase
MTMPTNASAAAHALTDVTASDSTLRRFLHGLPGVDAVGLEGRAASLGTRSIKTTAKAYAIDLAISMVDLTTLEGADTPGKVRALGAKAVHPDPTDRTTPSTAAVCVYPDMVATAKAAVAGSTVKVASVATAFPAGRAPLGVKLADVREAVAAGADEIDMVIDRGAFLAGNYMKVYDEIVAVKEASGAARLKVIFETGELSTYDNIRRASWLGMLGGADFIKTSTGKVAVNATPANTLLMLEAVRDFRAQTGIQVGVKPAGGIRTSKDAIKFLVLVNETAGEDWLDNHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD
>NZ_CP023689.1|WP_150500070.1|3813689_3814376_-|PH-domain-containing-protein
MTTPEHPSPSPDPTSKDRVYRSPMGIVGGVALLVIVLWLGFDALLRGEGRTQWLALAAIILLVPLVIAFTLRPAVHANEDRLRIRNPLRVIVLPWGQVAALRSSYSNEVVAKSGTKFQLWAVPVSLRARKKAARRSARAASGRGDRGGRTGGGAGFGGLGFGAPRGDVDSDGPMRAETDKVMDDLRELLEQGENSESAQGEVTVRWAYEVAGPVVAGAVLLVILLAIG
>NZ_CP023689.1|WP_150500084.1|3823580_3824132_+|VanZ-family-protein
MQRQGSIGGSAAIRIRVTGGILLLAHLAFVAWLTLRPLDVPWVTPANLQPFAGIRADLALGWQEAARRIIEGLALLAPLGVLIPTAHGSLTASPLGSLVRTVAAGALISLGIELLQTGVPGQVVDVDSLLLNTLGVALAHAAIVPAARIHLRRRSERADRPATPQDEPTQGRTPTIPRVGIAP
>NZ_CP023689.1|WP_093747093.1|3824240_3824441_+|PspC-domain-containing-protein
MTALARPTNGRMIGGVCAALARRFGTSATTMRVIFLLSCLLPGPQFLLYIAMWILLPSENKTRTAW
>NZ_CP023689.1|WP_107903770.1|3824582_3825005_-|ATP-binding-protein
MKQSAAKTLGVAALGAAFAAAGAGAANAAPVAPDAAGSALDNVTRTLPAENLAQSAPGAGAGLAQGGAGLAQGQEALAAGLSAAQPAAEQAVAGGPTGVVAGLLGGLPVQGAAAEGLPVQGLPVQGLPTQGLPVNGLPLG
>NZ_CP023689.1|WP_150500086.1|3825143_3826340_-|adenosine-deaminase
MTSETAQKANTPSSDQIRRAPKVLLHDHLDGGLRPGTIVELARDTVPHSLNGAGGAPITHLPETDPDKLGVWFRDAADSGSLERYLETFSHTVGVMQTRDALVRVARECAEDLAEDGVVYAEVRYAPEQHLEGGLSLEEVVEAVNEGFREGELIARENGHRIRVGALLTAMRHAARALEIAELANRYRDLGVVGFDIAGAEAGHPPTRHLDAFEYLKRENNHFTIHAGEAFGLPSIWQALQWCGADRLGHGVRIIDDIQVHADGSVKLGRLASYVRDKRIPLELCPSSNLQTGAADSYAEHPIGLLRRLHFRATVNTDNRLMSHTSMSREFEHLVEAFGYTLDDMQWFSVNAMKSSFIPFDERLAMINDVIKPGYAELKSEWLFRQTSSTSDSAEEQG
>NZ_CP023689.1|WP_107903774.1|3826474_3827236_+|alpha/beta-hydrolase
MAQQATPVRRVRLGKAIGPEPTAVSGVVLLLPGGDETSHRKPAPLLATNYVRTLGRRLTRAGRDDGLATHVVRYRYRGWNGSAANLASDALWAADEAVRRYGDVPVCLVGVDMGARAALHAGGHEAVNSVLAIAPWLPEEDMAAAPEPVKQLAGRRVLFVHGTNDERTDPELSFRLAERAKKANRDVCRFEVHSDRHALHQHRDEVLALAQDFVMGVLFGRAFSRPVADAFAAPPPLGLRMPLASGFGKSLRR
>NZ_CP023689.1|WP_126899733.1|3827262_3828216_-|LysR-family-transcriptional-regulator
MEHQQRSRARLSPSSDTEDMTMLLAPRLAHFAGVARTEHVTRAAQEMRVPQSTLSRAMVRLEQDLGVDLFARHGRTVSLTPAGRTFLASVERALAEIGRAAEEVRADADPATGKVAFGFLHTMGAETVPGLIHAFRADHPRIRFSLVQNYGEAMIERLRSGELDLCLTSPVPDAPDLVARRLDEQKLRLVVPADHRLASRKRVRLAEAADETFVTLEPGYGMRRITDDLCQEAGFKPRIAFEGEEAETLRGLVAAGLGVALLPPPAVPRPGVVELTVTAPRAAREIGVAWLADRPDTPPVAAFKKFLLSRRGNLLPT
>NZ_CP023689.1|WP_150500088.1|3828279_3829548_+|MFS-transporter
MSPASTGASITVDATPAVPVVDSRMAPGGPGYRRMSFALFLAGVATFALLYSTQALLPLISGEFGVAASEASWTVAAATGGLALFVLPMSALSERFGRRTVMTGSLAVAVTVGLVVPFAPNLTALVVLRAVQGAALAGLPASATAYLAEEVRPRALITAIGLFVAGNSVGGMSGRVITGWVAQEWGWRVAVGVIGVIAVACAVAFRLLLPAPRHFKAGSLRPRVLARTVRDHLANPLLRRLYAIGALFMTVFGGVYTVIGYRLTEAPFSLPQGIIGSIFLVYLVGTVSASTAGRLVGRLGRRGALYAAGGTTAAGLFLSLADSLPLVLLGLVLITGGFFAGHAVASSAVSKTATAGRAQAAALYQSAYYVGSSAGSTIGAIAFHAGGWTGTVGVGLLAVLGVVTITVLGTRAARAQQRLATA
>NZ_CP023689.1|WP_150500090.1|3829721_3830741_+|RNA-polymerase-subunit-sigma-70
MSDGTATKTTDLDVRLEKHRVELTGYCYRMLGSSFEAEDAVQDTMVRAWRSYDKFEGRSSLRSWLYRIATNVCLDMLTAGNKRARPMDLTESTPLAQAALSPRPDNTWLEPMPDSRVLPSTEDPAEAAVAKESVRLAFMAALQQLPPKQRAVLILREVLAWRATEVAELLGTTVASVNSALQRARATLAEQQQPGAQATVSDPLDDEQQKLLDRYVAAFEGYDMTALTALLHEDAIMTMPPFDLWLTGHDDIAGFMTTLGSACEGSRLVPVEVNGLPGFAQYKPDPEAGGYTPWAVQVLEISDGRLTGFHFFLDTKRWFPLFGLPLHLEAETNQVEEGV
>NZ_CP023689.1|WP_150500092.1|3830624_3831011_-|STAS-domain-containing-protein
MSYRLPPGLPHVDAMTPAVLVLAGPVTRDEVAGLCDDVRARLEAGGARVVVCDVGGLGPPGLGVVDLLARLQLAARRAGGRIRLRDPDPALHALLDLVGLRFEVEGQTEEREPALGVEEEVEPGEPAV
>NZ_CP023689.1|WP_150500094.1|3831197_3832118_+|AEC-family-transporter
MQGVLTGFAVIAVVIAVGYAIGRRGYLGDQGRDVLTKLAFHVASPALLFTTLAQTDLSVIFSSRLLVTALSTAAAAGVFVAVGVVRHWGVGRTTIGALCSSYVNSGNLGIPIAVYVLGDASLVAPVLLFQLVGVTPVALTILDLSGKGEKGPLWRRMLTPLRNPIAVGSLAGVAVSATGLRIPAPVLDPLTLIGGMSVPAVLLAFGISLCGSTMPGRGPDRHPVFLSVALKSVGQPAAAWALAAGVFGLRGAPLLDVVVTSALPAAQNLYTYASSYRVAERLARDSILLSTVISVPVLVMVAAMLG

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Crispr_ID: NZ_CP023689_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_4

4063136-4063300

Orphan

Consensus_repeat	Method
GGCGGAGCGTCGAGCGGAGGCTGCCACGCTCGCGACGCCACGGCGAAGCGGCGAT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_4

>merge|NZ_CP023689|4|4063136-4063300|CRISPRCasFinder
GGCGGAGCGTCGAGCGGAGGCTGCCACGCTCGCGACGCCACGGCGAAGCGGCGATAGACACGACTCGCCTCGGCCCGTAAGGAACCTCGGGTCTCGTACGAACTGCCCACGGCGGAGCGTCGAGCGGAGGCTGCCACGCTCGCGACGCCACGGCGAAGCGGCGAT

>NZ_CP023689|4|4|4063136-4063300|CRISPRCasFinder
GGCGGAGCGTCGAGCGGAGGCTGCCACGCTCGCGACGCCACGGCGAAGCGGCGAT	AGACACGACTCGCCTCGGCCCGTAAGGAACCTCGGGTCTCGTACGAACTGCCCAC
GGCGGAGCGTCGAGCGGAGGCTGCCACGCTCGCGACGCCACGGCGAAGCGGCGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150500330.1\|4064981_4066178_+\|NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|181262
NZ_CP023689.1\|WP_125527848.1\|4058560_4059106_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	unknown	unknown	gnl\|CDD\|376771
NZ_CP023689.1\|WP_125527847.1\|4059071_4060313_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP023689.1\|WP_107904057.1\|4060476_4061643_-\|alanine-racemase	unknown	unknown	gnl\|CDD\|143481
NZ_CP023689.1\|WP_125527851.1\|4056722_4057379_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	unknown	unknown	gnl\|CDD\|274750
NZ_CP023689.1\|WP_093748897.1\|4062710_4063082_+\|holo-ACP-synthase	unknown	unknown	gnl\|CDD\|234610
NZ_CP023689.1\|WP_150500337.1\|4073044_4074403_-\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237672
NZ_CP023689.1\|WP_030952202.1\|4055075_4056206_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_CP023689.1\|WP_107904070.1\|4068969_4069785_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|272861
NZ_CP023689.1\|WP_150500336.1\|4072018_4072957_+\|DUF389-domain-containing-protein	unknown	unknown	gnl\|CDD\|129372
NZ_CP023689.1\|WP_030950653.1\|4074638_4075160_-\|30S-ribosomal-protein-S9	unknown	unknown	gnl\|CDD\|178888
NZ_CP023689.1\|WP_167537719.1\|4071033_4072002_+\|type-I-pantothenate-kinase	unknown	unknown	gnl\|CDD\|235466
NZ_CP023689.1\|WP_150500328.1\|4063340_4064780_+\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
NZ_CP023689.1\|WP_150500326.1\|4058172_4058364_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107904059.1\|4061699_4062608_-\|L,D-transpeptidase	unknown	unknown	gnl\|CDD\|341130
NZ_CP023689.1\|WP_030952200.1\|4056198_4056672_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NZ_CP023689.1\|WP_150500334.1\|4069781_4070852_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|130256
NZ_CP023689.1\|WP_150500332.1\|4066187_4066952_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_125529618.1\|4066986_4068834_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	unknown	unknown	gnl\|CDD\|234729
NZ_CP023689.1\|WP_150500324.1\|4057605_4058160_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150500330.1\|4064981_4066178_+\|NAD(P)-binding-protein	gnl\|CDD\|181262	PRK08163, PRK08163, 3-hydroxybenzoate 6-monooxygenase.	7.81743e-85
NZ_CP023689.1\|WP_125527848.1\|4058560_4059106_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE	gnl\|CDD\|376771	pfam02367, TsaE, Threonylcarbamoyl adenosine biosynthesis protein TsaE. This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).	2.18157e-46
NZ_CP023689.1\|WP_125527847.1\|4059071_4060313_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.95605e-24
NZ_CP023689.1\|WP_107904057.1\|4060476_4061643_-\|alanine-racemase	gnl\|CDD\|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	8.44256e-155
NZ_CP023689.1\|WP_125527851.1\|4056722_4057379_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB	gnl\|CDD\|274750	TIGR03725, T6A_YeaZ, tRNA threonylcarbamoyl adenosine modification protein YeaZ. This family describes a protein family, YeaZ, now associated with the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family may occur as fusions with ygjD (previously gcp) or the ribosomal protein N-acetyltransferase rimI, and is frequently encoded next to rimI. [Protein synthesis, tRNA and rRNA base modification].	5.4416e-63
NZ_CP023689.1\|WP_093748897.1\|4062710_4063082_+\|holo-ACP-synthase	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	6.28719e-49
NZ_CP023689.1\|WP_150500337.1\|4073044_4074403_-\|phosphoglucosamine-mutase	gnl\|CDD\|237672	PRK14318, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_CP023689.1\|WP_030952202.1\|4055075_4056206_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	0
NZ_CP023689.1\|WP_107904070.1\|4068969_4069785_-\|ABC-transporter-permease	gnl\|CDD\|272861	TIGR00025, Mtu_efflux, ABC transporter efflux protein, DrrB family. The seed members for this model are a paralogous family of Mycobacterium tuberculosis. Nearly all proteins scoring above the noise cutoff are from high-GC Gram-positive organisms. The members of this paralogous family of efflux proteins are all found in operons with ATP-binding chain partners. They are related to a putative daunorubicin resistance efflux protein of Streptomyces peucetius. This model represents a branch of a larger superfamily that also includes NodJ, a part of the NodIJ pair of nodulation-triggering signal efflux proteins. The members of this branch may all act in antibiotic resistance.	7.27454e-18
NZ_CP023689.1\|WP_150500336.1\|4072018_4072957_+\|DUF389-domain-containing-protein	gnl\|CDD\|129372	TIGR00271, Uncharacterized_protein_MJ0678, uncharacterized hydrophobic domain. This domain is in a family of archaeal proteins that includes AF0785 of Archaeoglobus fulgidus and in several eubacterial proteins, including the much longer protein sll1151 from Synechocystis PCC6803.	3.85135e-61
NZ_CP023689.1\|WP_030950653.1\|4074638_4075160_-\|30S-ribosomal-protein-S9	gnl\|CDD\|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	1.39635e-73
NZ_CP023689.1\|WP_167537719.1\|4071033_4072002_+\|type-I-pantothenate-kinase	gnl\|CDD\|235466	PRK05439, PRK05439, pantothenate kinase; Provisional.	0
NZ_CP023689.1\|WP_150500328.1\|4063340_4064780_+\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	3.50449e-59
NZ_CP023689.1\|WP_107904059.1\|4061699_4062608_-\|L,D-transpeptidase	gnl\|CDD\|341130	cd16913, YkuD_like, L,D-transpeptidases/carboxypeptidases similar to Bacillus YkuD. Members of the YkuD-like family of proteins are found in a range of bacteria. The best studied member Bacillus YkuD has been shown to act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking. Another member Helicobacter pylori Csd6 functions as an L,D-carboxypeptidase and regulates helical cell shape and motility. The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.	1.01266e-18
NZ_CP023689.1\|WP_030952200.1\|4056198_4056672_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	4.79111e-29
NZ_CP023689.1\|WP_150500334.1\|4069781_4070852_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|130256	TIGR01188, drrA, daunorubicin resistance ABC transporter ATP-binding subunit. This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other].	1.9374e-115
NZ_CP023689.1\|WP_125529618.1\|4066986_4068834_-\|glutamine--fructose-6-phosphate-transaminase-(isomerizing)	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0

>NZ_CP023689.1|WP_093748897.1|4062710_4063082_+|holo-ACP-synthase
MSIIGVGIDVAEIDRFEAALERTPGLAERLFLERELLLPSGGRRGIASLAARFAAKEALAKALGAPAGLLWTDAEVCVEDSGQPRLRVTGTVAARAAELGVRSWHVSLSHDAGVASAVVIAEG
>NZ_CP023689.1|WP_107904059.1|4061699_4062608_-|L,D-transpeptidase
MSRRIARRSVAVLLAGAVIMPVGGASADPADSSDPVPPTSGPQTADLVPGIPLTLLPLSEMDTPDQALPPKVYKPTRAEEAVEPKDAPEEAYDRVEYVDPMDSFGDVTCSEETGLRQREVERWLKRPVDGEQSKGDCKAIRVFQKKYRIKPAIGYAGPVTWATMQLVGARKNPNAAKKCPVRAYRVACVDLDRQIAWVQHGKGGVVFGPVPIRSGRTGYGTRNGWHAVYWRHKNHVSTLYKSPMPYSQFFSGGQAFHGVYGSLYTPVGSRGCVNMTLKDSRKLWGLLKKGDRVYVWGHRQEQ
>NZ_CP023689.1|WP_107904057.1|4060476_4061643_-|alanine-racemase
MTETTALRTAPLRARAEIDLAALRSNVLSLRAHAPGAALMAVVKSDAYGHGAVRCARAAVDAGATWLGTATPEEALVLRAAGLRGMRMMCWLWTPGGPWREAVEADVDVSVSGMWALREVTEAARQAGAPARVHLKADTGLGRGGCQPGDDWAELVREALRAEAEGLLSVTGLWSHFACADEPGHPSIAAQLTRFREMVAYAEGQGARPEVRHIANSPATLTLPDSHFDLVRTGIATYGISPSPELGSPADFGLRPVMTLSASLALVKHVPGGHGVSYGHRYVTPGETTLGLVPLGYADGIPRHASGAGPVLVGGKWRTVAGRIAMDQFVVDLGGDEPEPGAQAVLFGPGDGGEPTAEDWAQAAGTIAYEIVTRIGTRVPRVYRNASM
>NZ_CP023689.1|WP_125527847.1|4059071_4060313_-|alpha/beta-hydrolase
MSESSAEAVAAVASATGAAANWRRATGIAGAAIGVIAAGAAAGVAIERMTVGRGMRQKARLALDSAGPYGSLRGTPGKAYSDDGTELYYEVDDIDPEAAPALSPRRRRLFGRKAPAPVTVVFSHGYCLSQDSWHFQRAALRGVVRTVHWDQRSHGRSGRGVAQTQEGRHVDIEQLGRDLKAVIDAAAPEGPLVLVGHSMGGMTVMALADQFPDLIRDRVVATALVGTSSGKLGEVNFGLPVAGVNAVRRVLPGVLKALGQRAELVERGRRATADLFAGIIKRYSFSSRDVDPAVARFAERMIEGTPIDVVAEFYPAFADHDKTEALALFTDMPVLVLAGVGDLVTPSEHSEAIADHLPEAELVLVPDAGHLVMLEHPEVVTDRLADLLTRAGAVPAGATVSGYGSTSSTAQRG
>NZ_CP023689.1|WP_125527848.1|4058560_4059106_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-ATPase-subunit-type-1-TsaE
MEAPAAPHNAGDLQLTVTAPDQMRELGRRLAKLLRAGDLVMLSGELGAGKTTLTRGLGEGMGVRGAVTSPTFVIARVHPSLGDGPPLVHVDAYRLSGGLDEMEDLDLDVSLPDSVIVVEWGEGKVEELTEERLQVVIHRAVGTASSRGATPGPPETDEVRHVTVTGLGERWATADLSVLSA
>NZ_CP023689.1|WP_150500326.1|4058172_4058364_-|hypothetical-protein
MPASENTAQQRPEVTAGVSMRDLLAAGAAARLISTPPREPEAGRPRQHGRPEHPPRTTHREAA
>NZ_CP023689.1|WP_150500324.1|4057605_4058160_+|hypothetical-protein
MAGSSSSIVAGLTAAALATVGFLAFRASATVPADLAGPRGGDVQGVSASKVPRDREDPDALPDGSGTGQRVVYSVDDDRVWLVAGGGKVKRTFRVYPGSVDPPTGVYAVTSRSNAATGTDGASIEHVIRFASVDTVTIGFSTTVRSPSTHPDPALETGGIRESRADGDAMWDFATIGRAVVVIR
>NZ_CP023689.1|WP_125527851.1|4056722_4057379_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-dimerization-subunit-type-1-TsaB
MLLLALDTATPAVTVALHDGTDVIASSSQVDARRHGELLLPAVDRVLAEAGKRLDAVTAIVVGIGPGPYTGLRVGLMTADTFGLALGVPVHGLCTLDGLAYAADIEKGPFVVATDARRKEVYWARYADSRTRLTDPAVDRPADIADEVAGLPAVGAGALLYPDTFPRAHEPEHVSAAALAALAAEKLAAGEELPAPRPLYLRRPDAQVPKNYKVVTPK
>NZ_CP023689.1|WP_030952200.1|4056198_4056672_-|ribosomal-protein-S18-alanine-N-acetyltransferase
MRWWDIDRVLELEKDLFPEDAWSRGMFWSELAHSRGPEATRRYVVAEGPDRVVGYAGLASAGDLADIQTIAVARDHWGTGLGGRLLTELLRAAGDFECAEVMLECRVDNVRAQKLYERFGFEAIGFRRGYYQPGNVDALVMRLTAPENSVQGTEING
>NZ_CP023689.1|WP_030952202.1|4055075_4056206_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MADSRDVPLVLGIETSCDETGVGIVRGTTLLADAVASSVDEHARFGGVVPEVASRAHLEAMVPTIDRALKEAGVSARDLDGIAVTAGPGLAGALLVGVSAAKAYAYALGKPLYGVNHLASHICVDQLEHGALPEPTMALLVSGGHSSLLLSTDITSDVRPLGATIDDAAGEAFDKIARVLNLGFPGGPVIDRYAREGDPNAIAFPRGLTGPRDPAYDFSFSGLKTAVARWIEAKRAAGEEVPVRDVSASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVAANSRLRALAQERCEAAGIRLRVPRPKLCTDNGAMVAALGAEMVARNRSASSWDLSADSSLPVTDPHVPGNFTDEAHGHTHDHDHVHEVSKENLYS
>NZ_CP023689.1|WP_150500328.1|4063340_4064780_+|NAD(P)H-hydrate-dehydratase
MRTAYGVETVRAAERELMARLPDGALMQRAAAGLAAACADLLGRVYGSRVVLLVGSGDNGGDALYAGARLARRGAGVTAVLLAPERAHAGGLAALRRAGGRPVGLDAAEELIERADLVVDGIVGIGGKGGLRPDATPLADAAARSGAAVVAVDLPSGVDADTGEVRGAAIRADLTVTFGTHKPGLLIDPAREYAGVVRLVDIGLALPADAAELEALQHADVARLLPLPGAETDKYRRGVVGIAAGSSRYPGAAVLAVAGALRGGAGAVRYVGPAADAVIARFPETLVSDRGPKKAGRVQAWVVGPGAGDDASTVAEVLATDVPVLLDADGLRLADAGTVRERGAPTLMTPHAGEAAALLGVSREEVEGARLASVRELARRYAATVLLKGSTTLVARAGGAGAVRVNPTGTGWLATAGSGDVLSGLGGSLLAAGLPAVDAASAAAYLHGLSARFAADGAPLGAHDVAAGIPEAWRDVRVG
>NZ_CP023689.1|WP_150500330.1|4064981_4066178_+|NAD(P)-binding-protein
MRAIVVGAGIGGLAAALSLRRAGVDVTLVEQARRFSEIGAGIQLAPNATRELRRLGVLDPVAALAAHPPQVSFLTWSDGSEICRYALGREAEEEFGAPYLVVHRADLHGALAAAVPPEAVLLDTAVVAIDQDDRAARVTTATGERLEADLVVAADGIRSAARQWLFGEDSAVFSGTAAYRALLPAGEVTDLGLPPLAVWLGPDRHFVHYWVRRGELLNVVAVFTTRAATQESWTAKAEPGEPLRAFTDWDPRVRTVLERAGQVFRYGIHTRTPLTVWNTGRVTLLGDSAHAMVPFQAQGAAQAILDAAVLGDELTDATPGDVPAALDRYVRRRVPAANGMQSRSARAGRDFHLPDGPEAEARNARMAAHAAEHRFMPQAPAWRADVRHDHPPGPTSGA
>NZ_CP023689.1|WP_150500332.1|4066187_4066952_+|hypothetical-protein
MAKHPAPEVLYPDVVARGSLRAALQALADEGGLSVPFTAEDPGALTYAVAESGLPHRKRLLVNSWVHERRWSIRGEETAQGLALVQGDTDDLAQVARAAHAWHDGAALSDIRAAAPFVRLTGRFEVPDHDPVRLAESEWQHMRAEAGEQNWPAYQALVEAAYAEPALRALYPFTSHWTLRFSATTRPGLTITGPCLLALGVEEYLVSKGFTGADPLARTTTAQEAVAAAVRHLPAGLGPVASGAFDESGRSGPQ
>NZ_CP023689.1|WP_125529618.1|4066986_4068834_-|glutamine--fructose-6-phosphate-transaminase-(isomerizing)
MCGIVGYVGSQSALDIVMAGLRRLEYRGYDSAGVAVLADGGLAGAKKAGKLANLEKELAERPLPSGTTGIGHTRWATHGGPTDGNAHPHLDNAGRVAVVHNGIIENFAALRAELAERGHELASETDTEVVAHLLAEEFSAGADLAEAMRLVCRRLEGAFTLVAVHADEPDVVVGARRNSPLVVGVGEGEAFLASDVAAFIDHTRSAVELGQDQVVELRRDGVTVTGFDGRPADVRSYHVDWDASAAEKGGYDYFMLKEIAEQPKAVADTLLGRIDAAGSLTLDEVRISASELREVDKVVIVACGTAFHAGLIAKYAIEHWTRIPCEVELASEFRYRDPILDQQTLVIAISQSGETMDTLMALRHAREQGAKVLAICNTNGSTIPRESDAVLYTHAGPEVAVASTKAFLTQLVACYLVALYLGQVRGTKWGDEIHAVIRDLAQIGRQVERVLETMEPVRELARSLAHKNTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDDLPVVVVVPSPRGRSVLHDKIVSNMQEIRARGARTIVIAEEGDEAVVPYADHLIRIPVTPTLLQPMVAAVPLQVFACELATARGNEVDQPRNLAKSVTVE
>NZ_CP023689.1|WP_107904070.1|4068969_4069785_-|ABC-transporter-permease
MTAAATTVTAPITKSGRVRPLDGLRQTFTMAWRSLVAVKHNPLELVDYSITPIMFVFLFTYVLGGQMAGSPEAYLKYALPGIIVQNTLFMTMYTAMALNTDLTKGVFDRLRSLPIARSAPLIGRITADLAKHLWALLLMIGLGLLLGFRVTGGVGGFLLGTLLVIVFAAAVSWSAVLIGMLAGDAEKVQAFAFTIIFPITFTSSAFVMVDTMPGWLQAWSDVNPVTHLSDAFRGLLLGGPVAGPVLWSLVWAAGIAVVFYPLAMRAYRAKT
>NZ_CP023689.1|WP_150500334.1|4069781_4070852_-|ATP-binding-cassette-domain-containing-protein
MTTYAIEAEGLVKRFKETEALAGVDLGARRGSVLGLLGPNGAGKTTAVRIFATLLRPDGGRARVAGHDVVREAGVVRAMVGLTGQYAAVDENLTGTENLLLIGRLLGLPRPEARARAAELLERFQLADAAGRATKTYSGGMRRRLDLAASLVGRPSILFLDEPTTGLDPHSRGELWDLLRGLVADGATALLTTQYLNEADVLADDIVVIDKGRVIAEGTPDQLKSQVGGQVLELRPVLADDLARVHALVAEAAGPQTQIEGETITAPVKDPQLMPAVVRTLDREGIAVGELALRRSSLDEVFLALTGHRAEPGGPEGDGDTDGGDGDGGGEADGDGGRGAAVRDGEGEWEKAVSRS
>NZ_CP023689.1|WP_167537719.1|4071033_4072002_+|type-I-pantothenate-kinase
MPRSAHRQRPEATPYVDLTRSEWSALRDKTPLPLTAEEVEKLRGLGDVIDLDEVRDIYLPLSRLLNLYVGATDGLRGALNTFLGEQGSQSGTPFVIGVAGSVAVGKSTVARLLQALLSRWPEHPRVELVTTDGFLLPTKELQARGLMSRKGFPESFDRRALTRFVADIKAGKDEVTAPVYSHLIYDIVPDQRLTVRRPDILIVEGLNVLQPALPGKDGRTRVGLADYFDFSVYVDARTEDIETWYLNRFKRLRETAFQNPSSYFRKYTQVSEEEALDYARTMWRTINKPNLVENIAPTRGRATLVVRKGPDHKVQRLSLRKL
>NZ_CP023689.1|WP_150500336.1|4072018_4072957_+|DUF389-domain-containing-protein
MLHLRLITPSDKTDDVVRLIESTVGTTHLAVLPGVARNPAGDMVLCDVAREAGDELLTDLQRLGIEERGSIAVENIDLSLSKRADKAEDEAPGEGADAVLWEHLADATDEESTLSVTYVAFITLATMIAACGVVLDNAVLIVGAMAVGPEFGPLAGISTAVVQRRPRLALRSLIALVAGFALAMAVTVGFSWFMDALDLFSREQLEGDRPNTGFVYAPDAFSFIVAVLAGIAGTLSLTSAKSGALVGVAISVTTVPAAANAAVALSYGDTEQTWGSTEQLLLNLLGIVVAGTLTLLTQKWLWSRQRRTLQRP
>NZ_CP023689.1|WP_150500337.1|4073044_4074403_-|phosphoglucosamine-mutase
MGRLFGTDGVRGVANADLTAEMALGLSVAAAHVLAEAGTFEGHRPTAVVGRDPRASGEFLEAAVVAGLASAGVDVLRVGVLPTPAVAHLTGSLGADLGVMLSASHNAMPDNGIKFFARGGHKLADDLEDRIEAVYESHRHGEPWERPTGSGVGRVRSYDAGFGEYVTHLLNVLPNRLEGLKVVLDEAHGAAAGVSPEAFTRAGAEIVTIGAEPDGLNINDGCGSTHMEKLKAAVIEHGADLGIAHDGDADRCLAVDHTGEEVDGDQILAVLALAMRERSELRSETVVATVMSNLGFKLAMEREGIALVQTAVGDRYVLEEMKERGFALGGEQSGHVIILDHATTGDGTLTGLLLAARVAQTGRTLKDLASVMERLPQVLINVPDVDKSRVRTSGELASAVTEAERELGATGRVLLRPSGTEPLVRVMVEAADIDQARSVAGRLADAVKSALG
>NZ_CP023689.1|WP_030950653.1|4074638_4075160_-|30S-ribosomal-protein-S9
MAETTVEQPVEETELVDIDSYTTESEVPVEGEYTSESLASRFGEPQPAAGLGRRKNAIARVRIVPGTGKWKINGRTLEDYFPNKVHQQEVNEPFKVLELEGRYDVIARIAGGGVSGQAGALRLGVARALNEADVDNNRGPLKKAGFLKRDDRAVERKKAGLKKARKAPQYSKR

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Crispr_ID: NZ_CP023689_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_5

4921098-4921201

Orphan

Consensus_repeat	Method
GGCGGCTACGGCTACCCTCAGCCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_5

>merge|NZ_CP023689|5|4921098-4921201|CRISPRCasFinder
GGCGGCTACGGCTACCCTCAGCCCGCCGCGCCCGCGGGAGCCCCGCCCATGCCGCCGTCGCCGCCCGGCGGACGCCCCGGCGGCTACGGCTACCCGCAGCCCGC

>NZ_CP023689|5|5|4921098-4921201|CRISPRCasFinder
GGCGGCTACGGCTACCCTCAGCCCGC	CGCGCCCGCGGGAGCCCCGCCCATGCCGCCGTCGCCGCCCGGCGGACGCCCC
GGCGGCTACGGCTACCCGCAGCCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_107904943.1\|4921533_4922049_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|224630
NZ_CP023689.1\|WP_107904939.1\|4918113_4918476_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP023689.1\|WP_150501200.1\|4919550_4919913_+\|DUF1304-family-protein	unknown	unknown	gnl\|CDD\|377753
NZ_CP023689.1\|WP_150501198.1\|4916420_4917887_-\|DUF2252-family-protein	unknown	unknown	gnl\|CDD\|313268
NZ_CP023689.1\|WP_150501193.1\|4910425_4911172_-\|TrmH-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|334162
NZ_CP023689.1\|WP_030945481.1\|4931553_4931715_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107904949.1\|4930918_4931557_-\|aminodeoxychorismate/anthranilate-synthase-component-II	unknown	unknown	gnl\|CDD\|181107
NZ_CP023689.1\|WP_150506776.1\|4914622_4914952_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP023689.1\|WP_150501202.1\|4925183_4926659_+\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
NZ_CP023689.1\|WP_150501208.1\|4929677_4930922_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP023689.1\|WP_150501206.1\|4928902_4929664_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP023689.1\|WP_125527763.1\|4922139_4923720_+\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	unknown	unknown	gnl\|CDD\|223704
NZ_CP023689.1\|WP_150501195.1\|4911168_4912395_-\|HTTM-domain-containing-protein	unknown	unknown	gnl\|CDD\|214802
NZ_CP023689.1\|WP_107904944.1\|4923747_4925187_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl\|CDD\|223843
NZ_CP023689.1\|WP_150501210.1\|4931769_4932480_-\|class-E-sortase	unknown	unknown	gnl\|CDD\|320679
NZ_CP023689.1\|WP_150501204.1\|4926829_4928815_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	unknown	unknown	gnl\|CDD\|270916
NZ_CP023689.1\|WP_107904940.1\|4918627_4919278_+\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|224103
NZ_CP023689.1\|WP_150501197.1\|4912391_4913198_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150506778.1\|4915009_4915981_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
NZ_CP023689.1\|WP_125529626.1\|4913401_4914535_+\|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|224871

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_107904943.1\|4921533_4922049_+\|FHA-domain-containing-protein	gnl\|CDD\|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	5.50937e-20
NZ_CP023689.1\|WP_107904939.1\|4918113_4918476_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.72977e-32
NZ_CP023689.1\|WP_150501200.1\|4919550_4919913_+\|DUF1304-family-protein	gnl\|CDD\|377753	pfam06993, DUF1304, Protein of unknown function (DUF1304). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	9.85473e-38
NZ_CP023689.1\|WP_150501198.1\|4916420_4917887_-\|DUF2252-family-protein	gnl\|CDD\|313268	pfam10009, DUF2252, Uncharacterized protein conserved in bacteria (DUF2252). This domain, found in various hypothetical bacterial proteins, has no known function.	4.24664e-163
NZ_CP023689.1\|WP_150501193.1\|4910425_4911172_-\|TrmH-family-RNA-methyltransferase	gnl\|CDD\|334162	pfam00588, SpoU_methylase, SpoU rRNA Methylase family. This family of proteins probably use S-AdoMet.	1.78611e-33
NZ_CP023689.1\|WP_107904949.1\|4930918_4931557_-\|aminodeoxychorismate/anthranilate-synthase-component-II	gnl\|CDD\|181107	PRK07765, PRK07765, aminodeoxychorismate/anthranilate synthase component II.	1.41715e-143
NZ_CP023689.1\|WP_150506776.1\|4914622_4914952_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	1.06535e-24
NZ_CP023689.1\|WP_150501202.1\|4925183_4926659_+\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	2.93197e-86
NZ_CP023689.1\|WP_150501208.1\|4929677_4930922_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	1.66378e-49
NZ_CP023689.1\|WP_150501206.1\|4928902_4929664_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	2.64921e-37
NZ_CP023689.1\|WP_150501210.1\|4931769_4932480_-\|class-E-sortase	gnl\|CDD\|320679	cd05830, Sortase_E, Sortase domain found in the class E family of sortases. Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.	7.82067e-57
NZ_CP023689.1\|WP_150501195.1\|4911168_4912395_-\|HTTM-domain-containing-protein	gnl\|CDD\|214802	smart00752, HTTM, Horizontally Transferred TransMembrane Domain. Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.	1.24811e-36
NZ_CP023689.1\|WP_107904944.1\|4923747_4925187_+\|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl\|CDD\|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	2.02869e-79
NZ_CP023689.1\|WP_107904940.1\|4918627_4919278_+\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	2.41488e-47
NZ_CP023689.1\|WP_150501204.1\|4926829_4928815_+\|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.37202e-128
NZ_CP023689.1\|WP_125527763.1\|4922139_4923720_+\|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	1.2098e-81
NZ_CP023689.1\|WP_150506778.1\|4915009_4915981_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	0.00306276
NZ_CP023689.1\|WP_125529626.1\|4913401_4914535_+\|acyl-CoA-dehydrogenase-family-protein	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	1.75622e-43

>NZ_CP023689.1|WP_150501200.1|4919550_4919913_+|DUF1304-family-protein
MHAISVVLVALMALLHAYILVLEMFLWQRGPGRGLSGFDAEMARATAPLAANQGLYNGFLAAGLVWGLIADDPTGRQVQIFFLSCMVVAGVYGAATANRRILFVQALPAAVTLATVVAAG
>NZ_CP023689.1|WP_107904940.1|4918627_4919278_+|FMN-dependent-NADH-azoreductase
MATLLHIDSSVFSTGASSSRAVTDAFRRIWQEQHPEGTVIHRDLAAQPVPHIDAHSHTAGFSDPATHTPEQAAAFAERVKLIEELESADAVLIGAPMYNLTIPSTLKAYLDNVVLMGRTAGDAQSIKGTPVTVVASRGGAYGPGTPREGYEYVQNYLSAILADFLGADLDFIVPELTMAPANPAMAELVPLFEASRERALDEATTKAKQLAQKLAA
>NZ_CP023689.1|WP_107904939.1|4918113_4918476_-|helix-turn-helix-transcriptional-regulator
MAGEQSHDVAQCKRVDEGINRVFQLLGKRWTGPIVSVLTSGPAYFVALRRAIPGISERMLSDRLTELAAAGLVVREVYEGPPLRVVYRLTESGAALEPALAELGGWAKKYLGDGERPEGC
>NZ_CP023689.1|WP_150501198.1|4916420_4917887_-|DUF2252-family-protein
MTEVGAEAVAAEAAAAASESGERTASAARRLPRVQGFAEWPGGGSPKEEGKELRKRVPRAEHAVFDLDASRPGAVAAVEESNLGRLTDLTPIRVGRMAATPFAFLRGSAGLMAYDLARTPMTRIRAQICGDAHAANFGLYADARGGLVIDLNDFDETLYGPWEWDLKRLATSLVLAGREAGADEDKCRKAAHDTVGSYRRTMRLLAKLPVLDAWNAIADEELVSHTDAHDLLGTLERVAEKARANTSGRFAAKSTAPTEDGGRSFVDAPPVLRRVPDEEAAAVAASLESYVTTLSEDRHPLLSRHAVHDVAFRVVGTGSVGTRSYVVLLLDHRGEPLVLQVKEARPSALVPHLVTAGFEAPGTDHEGRRVVLGQKRMQVVSDILLGWTTVDGLPFQVRQFRNRKGSVDPAALAADQIDDYARMTGALLARAHSHSADPRLIAGYCGKNEELDEAIAEFALAYADRTEADHAELVTAVRDGRIAAEMGV
>NZ_CP023689.1|WP_150506778.1|4915009_4915981_-|hypothetical-protein
MTAAETADTAAESAGEAQQPADEAVEPAEGAVESAEEAAAAADEAVAVADEAVAAAEDAVAVEEPAERPEARLERAVRAAEQALIEYEIAVETFRVEVDNFSRLHHQKLGPMYTRLDELDARIAEAVAARTGDPEDIRKADEARARVMPMPGVEELFHGWMDGEGLFPEAAAMLTDQPVRPPQRVRPSDEARKLYRELARKAHPDLAQEEAERARREEFITRVNAAYARGDEALLRELAEEWAAGPAPKEQGPTPSEELYARLEWLAQRKEMLTLVAKDLEESAIGAMLRLAPDDPDRLLDEIAEQLLAQVAAREAELAALLG
>NZ_CP023689.1|WP_150506776.1|4914622_4914952_-|rhodanese-like-domain-containing-protein
MPTVEVTDLKDDDFLLDVREDDEWQAGHAHGALHIPISEFVARYGELTEAAPQDGRVNVICRSGGRSAQVAMYLVQQGVDAVNVDGGMQVWAAAGRPVVNNEGQPGFVL
>NZ_CP023689.1|WP_125529626.1|4913401_4914535_+|acyl-CoA-dehydrogenase-family-protein
MDFTFTEEQQAAAEAARGVFAGVAPDAVPSPALTPGAVADTFDRPLWDRLADADLLSLLLTEEYGGAGLDAVALCQVLRESAKVLARVPLLESSAAMAAVQAYGGPELKADLLARAGRGELVLTVAAHGRTGHDPAELATTARRDGSGWVLDGVQTAVAWAYDADLVAVPARTDADLTVLALVPRDTEGVSLAEQFSTSGERLGELRLESVRLTARDVIDTEGAWEWLRELLATGTCALALGLGERVLGMTSEYASKREQFGHPIATFQAVAVQSADRYIDLRAMEATLWQAAWRITSGASGALPASGDVAVAKIWASEGVRRVVQTAQHLHGGFGADVDYPLHRYHAWAKHLELTLGPAAAHEEALGDLLAAHPLG
>NZ_CP023689.1|WP_150501197.1|4912391_4913198_-|hypothetical-protein
MDAYDAGSAARHGPDREPPLVPPPAPPAEPSLALPPSPAPEPEARTGVAALSLRYQIVAALAVAVVAIVVCVHTGMVFLHVAPPNTVTKKHGGAIDDWIYPEFEQNWKLFAPNPLQQNIAVQVRAQVGTGGDGTRTTGWYDLSAQDGEAIDGNLLPSHTQQNELRRAWDFFVATHDTENRPVGLRGALSETYLRRIVELRLDRADAAGEGGVVERVQVRSRTTNVPPPKWSEEQISDKPSYRVLPWWSVPEDRAAAADAAGIGAGGTR
>NZ_CP023689.1|WP_150501195.1|4911168_4912395_-|HTTM-domain-containing-protein
MNRFALAVSSAIARVTESALGPYQTAVIRIGFSATWLLFLLREFPHRQELYGPGGPWDFDLAQQLIGTNGSFTALMWFRGGIWFETVYLFAVLTAVLLLVGWRTRAMSVLFMVGVLSLQNRSIFMGDGGDNVLHLMCVYLVFTRCGQVWSLDERRARRARDAHARGERVAPDRVGPALWSVSGFVLVAVTAAGRLDGDLTVPLILWISWLAPAVWWIVGRRARTAEPRILLDVIGNVVHNGALLVIMAEACLIYATAGWYKIQGSRWQDGTAVYYPLHLDYFSPWPALADVLSSSGTMVMLITYGTVVVQVAFPFTLFNRRVKNVLLAAMITEHAVIAVVLGLPFFSLAMIAADAVFLPASFLRRLGDLAARARGRLAGLVRRGDHPVKPPAPRSPENPEHAHVGSSA
>NZ_CP023689.1|WP_150501193.1|4910425_4911172_-|TrmH-family-RNA-methyltransferase
MTLASWNRLAETSVLLDGFHALKHAVRFGAEVPVAVAVDREAALALADELAPDVRDALDGLLTEVPEPTYKSLVPRPHPTAVAALAVRPSRAAGLGKLAHTPRTAPVVVLDNPRNLGNAGAVIRLAAGFGVTGVVTTGTLDPWHPTVVRGGAGLHFATVVERLTVPELPPGPLFALDPEGDDIRGVKLPDDAVLAFGSERSGLSAELRARTDHLLSLPMRPQVSSYNLATSVAMTLYHWSLTGGAARA
>NZ_CP023689.1|WP_107904943.1|4921533_4922049_+|FHA-domain-containing-protein
MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTQRGSRREAGRQQQAARQAAAPPQQRGQQAGGRQRRNAPSKLVVSEGTLTGTTVALQGQTITLGRAHDSTIVLDDDYASSRHARIYPDRDGQWIVEDLGSTNGTYLDRSRLTTPTPIPLGAPIRIGKTVIELRK
>NZ_CP023689.1|WP_125527763.1|4922139_4923720_+|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase
MYPEPTGEVRMSLSLRFAAGSHKGMIREGNEDSGYAGPRLLAIADGMGGAAAGEVASSEAISTIVALDDDVPGSDILTSLGTAVQRANDQLRSMVEEDPQLEGMGTTLTALLWTGQRLGLVHVGDSRAYLLRDGVLTQITQDHTWVQRLVDEGRITEEEATTHPQRSLLMRALGSGDHVEPDLSIREVRAGDRYLICSDGLSGVVSHQTLEDTLASYQGPQETVQELIQLALRGGGPDNITVIIADVLDLDTGDTLAGQLSDTPVVVGAVAENQPHHLHDNGIMQTPAGRASGLGRQVPGQGGGGGEFGPPGSGDTTGYAPAGGFGDYTDDDFVKPRKGRRWLKRSFYSVLALAVIGGGMYGGWRWTQTQYYVGTNEEHVALYRGISQDLAWVSLSKVEKDHPEIELKYLPPYQQKLVEATIAEGGLKDAQAKIDELQLQATACKKRAAQQAAQSEQNAKTGEGEAGGTTGTTRTSLTSKATPTPNPSASTKSPPPSTSPTPTATPSPGPTLSEEEQKVVSNCGTQ
>NZ_CP023689.1|WP_107904944.1|4923747_4925187_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MSSTTNSPTHHTSTIGAIGAPSRRNTELVLLAFAVVIPVFAYANVGLAMNDEVPAGLLGYGLGLGLLAGIGHLAVRKFAPYADPLMLPLATLLNGLGLVVIWRLDQSKRLSNYADAAPRQLLYSALGVALLVAVLVFLKDHRVLQRYTYISMAGALFLLILPLVPGLGANIYGAKIWINIPGLGTVQPGEFAKIVLAVFFAGYLMVKRDALALASRRFMGLYLPRGRDLGPILVVWVISILILVFETDLGTSLLFFGMFVIMLYVATERTSWIVFGLLMSAVGAVGVASFEPHIQTRVQAWLDPAREFQLSRAGVQDGILHSEQAMQALWAFGSGGTLGTGLGQGNSDLIGFAANSDFILATFGEELGLAGVMAILLLYGLIVERGVRTALAARDPFGKLLAVGLSGAFALQVFVVAGGVMGLIPLTGMTLPFVAYGGSSVIANWALIGILLRISDTARRPAPAPAPNPDAEMTQVVRP
>NZ_CP023689.1|WP_150501202.1|4925183_4926659_+|penicillin-binding-protein-2
MNKPLRRIAIFCGLLVLALLIRDNWIQYVQADELRTDKANRRVTIERYGTPRGNIIVDGKAITGSKETSGTDFKFKRTYTNGPMWAPVTGYASQAFGANQLEYIEDGILTGNDDRLFFRNTLDMLTGKEREGGNVVTTLNAAAQKAAYEGLKDRGKGAVVALEPSTGKILALASFPSYDPSSFAGNSTTTDSKAWTKLQKKNNPDDPMLNRALREVYPPGSTFKVVTAAAALEHGLYTDADAKTDSPDPWVMEGTTTKLPNEGTIPCKNATLRVALKFSCNTVFGKVGSDLGNDKMLETAKKFGFTEEQFTPTRTSASVFSDDMNPSQTALSSIGQFNTAATPLQMAMVASAVANNGTLMKPYMIDELQTNNLDAIEKTDPEEMSKPLSAENAQKLQSMMETVVEDGTGKNAQISGVKVGGKTGTAQHGVDNSENPYAWFISYAKLDDGSAPVAVAVVVEDQNAVRDDISGGGLAAPIAKSVMEAVIKSKK
>NZ_CP023689.1|WP_150501204.1|4926829_4928815_+|Stk1-family-PASTA-domain-containing-Ser/Thr-kinase
MEEPRRLGGRYELGQVLGRGGMAEVYLAHDTRLGRTVAVKTLRADLARDPSFQARFRREAQSAASLNHPAIVAVYDTGEDYIDNVSIPYIVMEYVDGSTLRELLHSGRKLLPERSLEMTIGILQALEYSHRSGIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQTSAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPPFVGDSPVAVAYQHVREEAQAPSVFDPEITPEMDAIVLKALTKDPNYRYQSADEMRADIEACLDGQPVAATAAMGSVGYGGYPDDQPTTALRSADAGATSMLPPMNPDDGGYGYDDRPDRRRQKKSNTSTILLAVAAVLVLVGAILIGKWVFDGDTASNSQVAVPNVVGETESSARDLLGNVDLTIGKVTKQECEDQSKGKICSQTPDSKTKVDKNTTVDIVVSTGAPKVSVPDVEGLPYEKAKSDLEDKGFDVQQKTEESDRNPGVVISQDPEGGTEQEKGSTITLTVAKEKEQSTVPDVLGKTCDEAKAQMEANDLSGNCQEVDTQDPNQVGKVISTSPTAGSAVDKDSTVTIQIGKQAKQKTPVPSVVGQTVGQAKQTLAAAGFTNIQFANGSDQNDTAFVTDQDPKGNQQVDDPANTQITLTTVGFGNGGNNNGGGDNGGIFG
>NZ_CP023689.1|WP_150501206.1|4928902_4929664_-|class-E-sortase
MAATTEGTEDHTAAPASRRPPVRRRRMGRIAMAVSVFGELLITAGLVLGLFVVYSLWWTNVIADRAADKQADKVRDIWAHQDDDSGRPAEFDAKNGIGFLHVPAMTKGEILVEKGTTSKILNDGVAGYYTDPVKATLPNSDKKGNFSLAAHRDGHGAKFHNIHKLEKGDPIVFETKDKWYVYKVYAVLPETSKYNVQVLGGIPKESGKTKAGHYITLTTCTPVYTSRYRYVVWGELERVDKVDEDRTLPEELR
>NZ_CP023689.1|WP_150501208.1|4929677_4930922_-|class-E-sortase
MTALRPERESGAAYGESFTDSYGDTGDQGSSYGQQPYEGSGALGEWYGEESYVTQAQQAAEARAAAGYGADGYGAGGYGSNGYAGQSYQAPVAQEPYAEPYMPPPDDETVALRVPDPPPSREPISPSPASSAASASSTPTGGRAARRKAAKRRHGRHGGTHQPSDAAETDSESSGAPLSRMEARRQARARKPGPATVASRAIGEVFITTGVLMLLFVSYQLWWTNIRAHAQADKEASSLQEDWASGKGNPGTFEPGQGFALLHIPKLDVVVPIAEGISNKKVLDRGMVGHYGEGKLKTAMPDAKTGNFGLAGHRNTHGEPFRYINRLAQGDEIVVETQDKYFVYKMASILPVTSPSNVSVLEPVPPGSGFTGPGRYITLTTCTPEFTSKYRLIVWGKMVEERPRSKGKPDALVS
>NZ_CP023689.1|WP_107904949.1|4930918_4931557_-|aminodeoxychorismate/anthranilate-synthase-component-II
MSARILVVDNYDSFVFNLVQYLYQLGAECEVLRNDEVSTTHAQDGFDGVLLSPGPGTPEEAGVCVEMVRHCASTGVPVFGVCLGMQSMQVAYGGVVDRAPELLHGKTSLVEHEGKGVFAGLPSPFTATRYHSLAAEPATVPADLEVTARTHDGIIMGLRHRELPVEGVQFHPESVLTEHGHRMLANWLVECGYEDAVARSAGLAPVVGRATA
>NZ_CP023689.1|WP_030945481.1|4931553_4931715_-|hypothetical-protein
MYGWIWRHLPGNAWVKALLSLALAMAVVYVLFNYVFPWAEPLLPFNDVTVDNQ
>NZ_CP023689.1|WP_150501210.1|4931769_4932480_-|class-E-sortase
MRVVVRTVSELCISAGTVIVLFVVYVLFWTGVKADNVMDDQIDQLQEQWAQSAVRPPDTAPGGAAASPGATASPPKPAPYTADKPFAIMYIPRLGFTWNKPVLEGTATKTLKKGLGHYANTAQLGQKGNFSVAGHRRTYGDPFKDFPRLRPGDAVVLTDGTTWFTYRIDKGPYKTLPADVEVIDPVPRKSGYTREGRYLTLTTCDPEWGHSHRLIVWAHLDSTQPVEAGKPEALRR

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Crispr_ID: NZ_CP023689_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_6

5108364-5108459

Orphan

Consensus_repeat	Method
CCCGTGCGGGGGTCGCCGCTGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_6

>merge|NZ_CP023689|6|5108364-5108459|CRISPRCasFinder
CCCGTGCGGGGGTCGCCGCTGGGGATGGGCCCGCAGCGCTCGGGGCGGGCCGGCCGGCTGACGCCGACGCCCACCCGCGCGGGGGTCGCCGCTGGG

>NZ_CP023689|6|6|5108364-5108459|CRISPRCasFinder
CCCGTGCGGGGGTCGCCGCTGGG	GATGGGCCCGCAGCGCTCGGGGCGGGCCGGCCGGCTGACGCCGACGCCCA
CCCGCGCGGGGGTCGCCGCTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150506800.1\|5103908_5104526_-\|LytR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379163
NZ_CP023689.1\|WP_107905100.1\|5117092_5118406_+\|carbohydrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224567
NZ_CP023689.1\|WP_003999914.1\|5104660_5104957_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	unknown	unknown	gnl\|CDD\|227737
NZ_CP023689.1\|WP_107905093.1\|5112784_5113258_+\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380376
NZ_CP023689.1\|WP_150501342.1\|5112164_5112788_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379237
NZ_CP023689.1\|WP_107905080.1\|5103245_5103881_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
NZ_CP023689.1\|WP_107905088.1\|5109215_5109935_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|99790
NZ_CP023689.1\|WP_107905341.1\|5107122_5107392_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107905342.1\|5108531_5109125_-\|Fe-S-cluster-assembly-protein-HesB	unknown	unknown	gnl\|CDD\|132296
NZ_CP023689.1\|WP_150501336.1\|5105212_5106871_+\|DUF853-family-protein	unknown	unknown	gnl\|CDD\|283518
NZ_CP023689.1\|WP_150501348.1\|5115989_5116856_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378822
NZ_CP023689.1\|WP_030952809.1\|5101106_5101286_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150501346.1\|5114206_5115973_+\|copper-resistance-protein-CopC/CopD	unknown	unknown	gnl\|CDD\|377255
NZ_CP023689.1\|WP_150501350.1\|5118411_5119389_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP023689.1\|WP_150501340.1\|5110012_5112172_+\|penicillin-acylase-family-protein	unknown	unknown	gnl\|CDD\|376618
NZ_CP023689.1\|WP_030952803.1\|5102912_5103107_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107905076.1\|5101596_5102028_-\|nucleoside-deaminase	unknown	unknown	gnl\|CDD\|223663
NZ_CP023689.1\|WP_150501338.1\|5107541_5108222_-\|HdeD-family-acid-resistance-protein	unknown	unknown	gnl\|CDD\|225786
NZ_CP023689.1\|WP_150501344.1\|5113254_5114022_+\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|235546
NZ_CP023689.1\|WP_107905078.1\|5102066_5102597_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274869

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150506800.1\|5103908_5104526_-\|LytR-family-transcriptional-regulator	gnl\|CDD\|379163	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator. This family appears at the C-terminus of members of the LytR_cpsA_psr, pfam03816, family.	6.67832e-14
NZ_CP023689.1\|WP_107905100.1\|5117092_5118406_+\|carbohydrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224567	COG1653, UgpB, ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism].	4.57134e-40
NZ_CP023689.1\|WP_003999914.1\|5104660_5104957_-\|type-II-toxin-antitoxin-system-VapB-family-antitoxin	gnl\|CDD\|227737	COG5450, COG5450, Transcription regulator of the Arc/MetJ class [Transcription].	9.09168e-08
NZ_CP023689.1\|WP_107905093.1\|5112784_5113258_+\|cupin-domain-containing-protein	gnl\|CDD\|380376	cd06121, cupin_YML079wp, Saccharomyces cerevisiae YML079wp and related proteins, cupin domain. This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.	6.86472e-65
NZ_CP023689.1\|WP_150501342.1\|5112164_5112788_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379237	pfam13523, Acetyltransf_8, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.45268e-50
NZ_CP023689.1\|WP_107905080.1\|5103245_5103881_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	3.13961e-116
NZ_CP023689.1\|WP_107905088.1\|5109215_5109935_-\|siderophore-interacting-protein	gnl\|CDD\|99790	cd06193, siderophore_interacting, Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from transferrin and lactoferrin for bacterial uptake, contributing to pathogen virulence. Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport mechanism of photosystem I. FNR transfers electrons from reduced ferredoxin to FAD (forming FADH2 via a semiquinone intermediate) and then transfers a hydride ion to convert NADP+ to NADPH. FNR has since been shown to utilize a variety of electron acceptors and donors and has a variety of physiological functions including nitrogen assimilation, dinitrogen fixation, steroid hydroxylation, fatty acid metabolism, oxygenase activity, and methane assimilation in a variety of organisms. FNR has an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) flavin sub-domain which vary in orientation with respect to the NAD(P) binding domain. The N-terminal moeity may contain a flavin prosthetic group (as in flavoenzymes) or use flavin as a substrate. Because flavins such as FAD can exist in oxidized, semiquinone (one-electron reduced), or fully reduced hydroquinone forms, FNR can interact with one and two electron carriers. FNR has a strong preference for NADP(H) vs NAD(H).	3.91893e-51
NZ_CP023689.1\|WP_150501350.1\|5118411_5119389_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	1.53174e-75
NZ_CP023689.1\|WP_107905342.1\|5108531_5109125_-\|Fe-S-cluster-assembly-protein-HesB	gnl\|CDD\|132296	TIGR03252, TIGR03252, uncharacterized HhH-GPD family protein. This model describes a small, well-conserved bacterial protein family. Its sequence largely consists of a domain, HhH-GPD, found in a variety of related base excision DNA repair enzymes (see pfam00730). [DNA metabolism, DNA replication, recombination, and repair].	4.59777e-100
NZ_CP023689.1\|WP_150501336.1\|5105212_5106871_+\|DUF853-family-protein	gnl\|CDD\|283518	pfam05872, DUF853, Bacterial protein of unknown function (DUF853). This family consists of several bacterial proteins of unknown function. BMEI1370 is thought to be an ATPase.	0
NZ_CP023689.1\|WP_150501348.1\|5115989_5116856_-\|hypothetical-protein	gnl\|CDD\|378822	pfam12158, DUF3592, Protein of unknown function (DUF3592). This family of proteins is functionally uncharacterized.This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.	0.00791544
NZ_CP023689.1\|WP_150501346.1\|5114206_5115973_+\|copper-resistance-protein-CopC/CopD	gnl\|CDD\|377255	pfam04234, CopC, CopC domain. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm.	1.83219e-26
NZ_CP023689.1\|WP_150501340.1\|5110012_5112172_+\|penicillin-acylase-family-protein	gnl\|CDD\|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	2.03275e-160
NZ_CP023689.1\|WP_107905076.1\|5101596_5102028_-\|nucleoside-deaminase	gnl\|CDD\|223663	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis].	8.34368e-66
NZ_CP023689.1\|WP_150501338.1\|5107541_5108222_-\|HdeD-family-acid-resistance-protein	gnl\|CDD\|225786	COG3247, HdeD, Uncharacterized conserved protein [Function unknown].	1.6597e-26
NZ_CP023689.1\|WP_150501344.1\|5113254_5114022_+\|glucose-1-dehydrogenase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	6.83261e-74
NZ_CP023689.1\|WP_107905078.1\|5102066_5102597_-\|hypothetical-protein	gnl\|CDD\|274869	TIGR03941, conserved_hypothetical_protein, putative tRNA adenosine deaminase-associated protein. This model describes a protein family about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologs of TadA, a tRNA-specific adenosine deaminase from Escherichia coli. Homology, phyletic pattern, and gene neighborhood together suggest a housekeeping function in tRNA metabolism. [Unknown function, General].	1.0664e-15

>NZ_CP023689.1|WP_150501338.1|5107541_5108222_-|HdeD-family-acid-resistance-protein
MTEAPGGSPWGRDYDDRRVHAGHPAGPPGPVAPHEPEPPFEGPLHALSRAAWQVVLVTGVASLVLGVFVLVWPDASLRVAGILFGLYLLISGVFQLVAAFGTHRTTSLRVLAFVSGTVSVLLGLFCFRGAMQSILLLALWIGIGWLFRGVTQALAAASDSSVPARGWQILLGVATFLAGVVLIVSPVESVTVLMVLGGCWLVTVGLVELVTALRLRKMAGRVPREL
>NZ_CP023689.1|WP_107905341.1|5107122_5107392_-|hypothetical-protein
MLLLALLVPGAHAQAHALPPVAAAAEIAEQDVLDTALRPVARAERRTSVRQRPGPPPGPATGTPASARRCAPPRPPYVPHVLRTVVLRC
>NZ_CP023689.1|WP_150501336.1|5105212_5106871_+|DUF853-family-protein
MSDRKSTPKAGTGAGTAPRAAAPEVSARAAALPREALEIAAGYAFTGPALHLGALLWEGGCLPDAQVRVPLPMLNRHGLVAGATGTGKTKTLQLIAEQLSAQGVPVFLADVKGDLSGVAAPGQPGDKVGARAAEVQQRWAAKGCPAEFYALGGIGRGIPVRATITSFGPVLLSKVLRLNPTQEQSLGLIFHYADTKGLDLVDLKDLRAVVAFLTSDEGKGELKGIGGLSTATAGVILRSLTAFEAQGMADFFGEPEFDTGELLRIAQDGRGVVSVLELAAVQDRPQLFSTFLMWLLADLFHDLPEVGDADRPKLVFFFDEAHLLFDDASEAFLDAITRTVRLIRSKGVGVFFVTQTPKDVPADVLGQLGNRIQHALRAFTPDDQKALKATVKTFPNSSYDLEELLTGLGTGEAVVTVLSEKGAPTPVAATRLRAPESLMGPLDAAELERAVTSSALYGRYAQAVDRESAYERLQASRGGKGPDEIRGGKGPDEIREAVGGAGEHRARQQKEQPSVVEQVVGSGMFKSLARSVGTQIGREITRSVFGTARRRR
>NZ_CP023689.1|WP_003999914.1|5104660_5104957_-|type-II-toxin-antitoxin-system-VapB-family-antitoxin
MIFKRIGNGRPYPDHGRESTRQWADVAPRPVRLDQLVTTKGQLDLETLLAEDSTFYGDLFAHVVKWQGDLYLEDGLHRAVRAALQQRQVLHARVLELD
>NZ_CP023689.1|WP_150506800.1|5103908_5104526_-|LytR-family-transcriptional-regulator
MGGQYRIKGDKYPRLRRRRRRGRFVVLAVVSVTALGVAGWGTLQLVDVFTGGGGEASAAGPKSDCGTRATPSPEATAPLPKPAGITVNVLNATTRSGLAKQTADELKKRGFKIGDVGNATKDYDKKVKGTGLLLGPAASLNTSLPVLATQLTTAERRTDATRKGATVDLIIGDRFKELTKKPDAEKALTALSNPKPTPSASKKGC
>NZ_CP023689.1|WP_107905080.1|5103245_5103881_+|uracil-phosphoribosyltransferase
MRLHVVDHPLVAHKLTTLRDQRTDSATFRRLADELVTLLAYEATRDVRTEAVDITTPVTATTGVKLSYPRPLVVPILRAGLGMLDGMVRLLPTAEVGFMGMVRDEETLQASTYATRMPEDLSGRQVYVLDPMLATGGTLVAAIQELIKRGADDVTAVVLLAAPEGVELMERELAGTPVTVVTAAVDDHLNEHGYIVPGLGDAGDRLYGAAE
>NZ_CP023689.1|WP_030952803.1|5102912_5103107_-|hypothetical-protein
MPDPESPERPTQDAPDESDAARRRRRAQFLRELAEARELRDRVQPRRAKAARLRHALRMRTFRW
>NZ_CP023689.1|WP_107905078.1|5102066_5102597_-|hypothetical-protein
MYFAALLARTEDGWEASDTELDDVETLSDLADLAREASPEDDTVLVLIEQEDAWFGVVRIDGEDDPRIYVSDAAAAARSSYGEILLTDELLGREPGDDDADLDSLDLDGTEEPDGDSEDDEDGSGADAVPHSPVGDSEILDDLGVGEKELKSLDAEDALSTIAEALGASEVLETVR
>NZ_CP023689.1|WP_107905076.1|5101596_5102028_-|nucleoside-deaminase
MQLALDEAEQAVRGGDVPVGAVLLSADGTTVLGAGHNEREATGDPTAHAEVLAIRRAAAELGEWRLTGCTLVVTLEPCTMCAGAIVQSRVDRVVYGARDEKAGAAGSLWDVVRDRRLNHRPEVIEGVLAEECARRLTDFFRSR
>NZ_CP023689.1|WP_030952809.1|5101106_5101286_-|hypothetical-protein
MAVNSKKIAVYVLAVFALYVIITDPAKAADYVQVGFEGISDAAKAIGDFMTWIANGGDS
>NZ_CP023689.1|WP_107905342.1|5108531_5109125_-|Fe-S-cluster-assembly-protein-HesB
MDVTLHLAQDPEADELLGRSALAALVGMLLDQQVPMEWAFKGPRTIADRLGADDLDAHDIAAQDPDAFVALLSEKPAVHRYPGSMAKRIQQLCQYLVERYDGDAELVWKGVDDGRELLRRLEDLPGFGKQKAQIFLALLGKQLGVHPKGWQEAAGAYGESESFRSVADITGPESLTKVRAHKQEMKAAAKAAKTARK
>NZ_CP023689.1|WP_107905088.1|5109215_5109935_-|siderophore-interacting-protein
MGQGHGWEGAVLKLLRAKDFVFTVTGAEDVTEHYRRVHLTDGGMLAATGVHPTMWVRLWFDNAGKPHQRAYTLVDPDPGAGTFSLEFALHEGVASDWARTAKPGDTIEATIHGTGFTQPEPAPSHVFAIADTASLPALNSLLDTLDAAPATVWFEGERDGLPFRAEESRHDVRTLPRRDSGAHLVAQVKENLPGLLADTPDPYVWIACDTATTRALTSYVRKELGLPKQRVNALGYWRP
>NZ_CP023689.1|WP_150501340.1|5110012_5112172_+|penicillin-acylase-family-protein
MTGEIFRDAWGIPHLRADGASELARAQGRVTALDRAWQLEVERHRARGTSASFLGAEALPWDRFVRRARLDDTARRCFAELERRDPETAGWVRAYVDGVNEGLDEGARRTTEFAKTGLAPGRWEPWTPLGVWLGIHILFAGFPAKLWREQVVRHLGADAVGLFAADGPGTSGSNGWLVSGERTVTGHAIIAGDPHRFIEDPGVYQQIHLSCPEFDVIGLAVPGIPGIAHFGHTGTVAWAITNAMADYQDLYRERLRRTGAGIEALDPDGVWRRAVRHTEVVEVAGEDPVEIEVIETARGPVVIGGPEGLPDGSQEHLEEGLPEGLQGEVQEGFPSGVSDDAPPLAMALRYPPRVTGDLGFGALLPLLRARRVADVDRAVDLWAEPVNVVQAADTEGGLLHRVAGKVPVRSAANGIGPVPAWEPGHDWDGWHETPRGGLTDGVAAMANQRGLAAPLGVEFAASHRADRITALLGEKERWSAADMPAIHMDTRLASAEALLDLLRTLGTLGPDAERIRRALLDWDRRMDADSEGAALYAAVRSAVVRRLAAHPAFAALAAAPAYPEVLLPWLALLPRVGFALEHLLRAEELYGIDRAEAVREAVEEVAAEPPSGGWGDTHRLAPWRALTDTAYDEPRLSGDHDCVLCTSAVPGITDLAARGPAARYVWDLADREAGSWLVPLGAWGIPGSPHHRDQLPLWVRGDLVPVVTDFTEFEKESDV
>NZ_CP023689.1|WP_150501342.1|5112164_5112788_+|GNAT-family-N-acetyltransferase
MSEPSTTIPGTAVRPVHEQAVDGFGSVRVRPLDPHADAAVVHGWTGAERASFWGMNGLTRDQVSEIYAHMAGLDTHHAYLILRDDVPVALLQTYEPEADRVSECYEVLPGDIGVHLLLAPAGPEGARPGWTSVLLGVVAAYVFGTLDRRRVVVDPDVRNEKAVARFLKQGFEAGPVVVLPEVDIPDVYIPAKEAQLAFLTREVAFGV
>NZ_CP023689.1|WP_107905093.1|5112784_5113258_+|cupin-domain-containing-protein
MTPEELVAHYSLEPIPREGGLFRRTWAGPELSDGRPQGTAIVVLLTTDDYSALHRLPSDEVWHFYLGDPLEMLLLAPDGTSRTAVLGPGIQRGEHIQLTVPAGTWMGARVAAGGSWTFFGCTMAPGFTYEGYEHGDLADLTARYPAEADRIAGLCRP
>NZ_CP023689.1|WP_150501344.1|5113254_5114022_+|glucose-1-dehydrogenase
MSGLLEGQVALVTGAGGGIGRGIATRFAEEGAAVVLHCRTAVDAADEVARRVRESGGRALVLRADLTDEDACGRLLGEAAEWGGGRLTALVNNAGVQPLRELPGMPAAEWRAVVDANLTSVFACTQAAAGIMRTQDGGGSVTHIASIEATHPAPLHAHYGAAKAAVRMHARSAALEYGPWGIRVNTVSPGLIHREGLEESWPEGVRRWKQAVPTGRLGRPEDVADACVFLASRLASWITGHDLVVDGGVSARPTW
>NZ_CP023689.1|WP_150501346.1|5114206_5115973_+|copper-resistance-protein-CopC/CopD
MLLGTLLVLFLLGGTGPASAHAALRATDPEDGSVLKSAPRDITLTFTESVGLLEDSFRVLDPDGRRLRTGEPEHARGGGAETATVTLPAKLAEGTYTVAWRVVSADSHPVSGAFTFSVGKPSLTTATLDTGPTEDPATKSLYNIARYLAYLAVALLIGTATFMAVCRPPDAPVLHRLLRAGWWTLLGATLALLVLRAPYESGEGPLGALSADSVTRTLTGRPGEVLLARLALLLVAALYLLRLARLRKPFGWAGAALAVGLAVTWAAGEHASAGIQVPVAMTSAALHLLATAVWLGGLTALLVTLYRARLTPAAVTRFSRVAFVSVTVLVVTGVYQSWRGLGSWDALTGTTYGRLLTLKLAAVVLLLAAAALSRRWTARLATVDAETAETVVEAEAAVREKVPEPVGGPSLPAGPEAAPEPSAPVEAGSEQRSALRRSVLAEVAVGAAVLAVTTLLTSTLPGRAEAEAAAGTPAVVGASVTNVPFDVGTPGGHGKVQVTIDPGRVGDNSIEALVYGPDGGVSVVPELRISFTLPAKDIGPVDAELTDKGGYWGNSFLNLPIAGKWEMKVTVRTTEVDQVSETRTVVIR
>NZ_CP023689.1|WP_150501348.1|5115989_5116856_-|hypothetical-protein
MTTSSTPSPLPSVTLRGRSGALWLEGGSLLLEQDGVRRRIPLPAVEAVRPAEGPRGVEVVLTAPEGAGATVYRVAHRAASARDAFVRTVNAALPAREAEEDRRDGATLVEVLPGTVRTAWYRKALGDAALVLAIGVPVVGWIAGLVTLLAHGDLIGAILWFFGTKPLIIGLVLYGMAAKTLYDRAILRRRGVSVLAAFHRHDGKKRLFRFTDLNGVPRECEVDNAAEPVGSGAERFEVSYDPEHPERVAARLPVRTWVLRSLGVGVFGTLFLYTGLYMVPYQLIQVLS
>NZ_CP023689.1|WP_107905100.1|5117092_5118406_+|carbohydrate-ABC-transporter-substrate-binding-protein
MQHFSPSGLSLPSPSRRTMLRGIGGAAVLGAGIPLLSACGGSGTASDPKTVTLGSKASDAVPKKAFADIYAAYKKKSGITVDVNTKDSNTFQEQINSYLQGTPDDVFTWFAGYRMQFFAAKGLATPIDDVWKTIGDNFPEAMHKLSKGEDGKYYFVPLYTYPWAIFYRKSVFQENGYEVPTTWDDFVALCKQMQKDKLVPIAFGDKDAWPALGTFDQINFRQNGYDFHVELMAGKASWTDAKVRKVFDLWTEILPYHQEGAMGRTWQDAAQTLASKKAGMYLLGTFVAQQFTDKAALDDLDFFAFPEIDPQFGQDTVEAPTDGFMMSKSPKNKAEAVKLLEFLGTPEAETVYLKSDPSSVHASTKADTSSYTALQKKAYDMIAGAKSLTQFMDRDSRPDFTSTVMQPALQKFVRDPKGVDGLLSSIERQKKTIFASG
>NZ_CP023689.1|WP_150501350.1|5118411_5119389_+|ABC-transporter-permease-subunit
MTTQTTKEIPEAAAVPPPGAAPAKKVSQGHRRLLTRRDRLTLGLMAGLPTILHIALVWVTALASVALAFTTWDGIGFDSIKWVGLENFKELFSNNPQFWPAVQHNVIWFVVLIVIPTPLGLFLAVQLDKRIRFSRVYQTAFFLPVVMSMAVIGFVWQLIYNPDTGLINSVIGANEPGKYIDWIGDPDLNLWAILVAASWRHTGYMMILYLAGLKGVDPSLREASALDGANEWQTFKNVIFPTLRPTNTVVLVVTIIEALRAFDLVFVFNKGAQGTELLSILVTNNIIGESSRIGYGSAIAVVLLLISLVVIIPYLVATFRKERRA

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Crispr_ID: NZ_CP023689_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_7

5172510-5172743

Orphan

Consensus_repeat	Method
TGACCGTGGCGGCTTCCGCCGTGACGACCGCGGTGACCGTGGNNNNNN	CRT

3 spacers

The CRISPR arrays of NZ_CP023689_7

>merge|NZ_CP023689|7|5172510-5172743|CRT
TGACCGTGGCGGCCGTTCCTTCGACCGTGACCGTGGTGGGCGTTCCTTCGAGCGCCGGGACAACGACCGTGGCGGCTTCCGCCGTGACGACCGCGGTGACCGTGGCGGCCGTTCGTTCGACGGTGACCGTGGCGGCTTCCGCCGTGACGACCGTGGTGACCGTGGTGGGCGTTCCTTCGAGCGTCGCGACGGTGACCGTGGCGGCTTCCGCCGTGACGACCGCGGTGACCGTGG

>NZ_CP023689|7|1|5172510-5172743|CRT
TGACCGTGGCGGCCGTTCCTTCGACCGTGACCGTGGTGGGCG	TTCCTTCGAGCGCCGGGACAA
CGACCGTGGCGGCTTCCGCCGTGACGACCGCGGTGACCGTGG	CGGCCGTTCGTTCGACGG
TGACCGTGGCGGCTTCCGCCGTGACGACCGTGGTGACCGTGG	TGGGCGTTCCTTCGAGCGTCGCGACGG
TGACCGTGGCGGCTTCCGCCGTGACGACCGCGGTGACCGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150501412.1\|5179389_5180031_-\|GTP-cyclohydrolase-II-RibA	unknown	unknown	gnl\|CDD\|234745
NZ_CP023689.1\|WP_107909506.1\|5159069_5159330_-\|DUF3073-domain-containing-protein	unknown	unknown	gnl\|CDD\|378620
NZ_CP023689.1\|WP_150501397.1\|5168074_5169646_-\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|365906
NZ_CP023689.1\|WP_150501399.1\|5169677_5170082_+\|metallopeptidase-family-protein	unknown	unknown	gnl\|CDD\|240572
NZ_CP023689.1\|WP_150501395.1\|5163637_5167615_-\|ATP-dependent-RNA-helicase-HrpA	unknown	unknown	gnl\|CDD\|182986
NZ_CP023689.1\|WP_107909491.1\|5183636_5184662_+\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP023689.1\|WP_150501406.1\|5175504_5177055_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|273331
NZ_CP023689.1\|WP_150501417.1\|5184787_5186137_-\|PrsW-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|379143
NZ_CP023689.1\|WP_107909507.1\|5157923_5158997_+\|phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
NZ_CP023689.1\|WP_150501415.1\|5182148_5183234_+\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP023689.1\|WP_150501410.1\|5178566_5179346_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293841
NZ_CP023689.1\|WP_107909503.1\|5163133_5163328_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150501400.1\|5170194_5170734_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_CP023689.1\|WP_150501408.1\|5177351_5178386_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225113
NZ_CP023689.1\|WP_150501393.1\|5159614_5160712_-\|Glu/Leu/Phe/Val-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
NZ_CP023689.1\|WP_150501414.1\|5180726_5181860_+\|5-amino-6-(5-phosphoribosylamino)uracil-reductase	unknown	unknown	gnl\|CDD\|180169
NZ_CP023689.1\|WP_125526532.1\|5160963_5161806_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_003949541.1\|5162388_5162595_+\|developmental-transcriptional-regulator-BldC	unknown	unknown	gnl\|CDD\|133390
NZ_CP023689.1\|WP_030960273.1\|5180143_5180659_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP023689.1\|WP_150501404.1\|5173350_5175456_+\|VCBS-repeat-containing-protein	unknown	unknown	gnl\|CDD\|379232

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_107909506.1\|5159069_5159330_-\|DUF3073-domain-containing-protein	gnl\|CDD\|378620	pfam11273, DUF3073, Protein of unknown function (DUF3073). This family of proteins with unknown function appears to be restricted to Actinobacteria.	1.64913e-21
NZ_CP023689.1\|WP_150501397.1\|5168074_5169646_-\|metallophosphoesterase	gnl\|CDD\|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	1.19947e-13
NZ_CP023689.1\|WP_150501400.1\|5170194_5170734_+\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	9.6777e-06
NZ_CP023689.1\|WP_150501395.1\|5163637_5167615_-\|ATP-dependent-RNA-helicase-HrpA	gnl\|CDD\|182986	PRK11131, PRK11131, ATP-dependent RNA helicase HrpA; Provisional.	0
NZ_CP023689.1\|WP_107909491.1\|5183636_5184662_+\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	4.09151e-36
NZ_CP023689.1\|WP_150501406.1\|5175504_5177055_+\|amino-acid-permease	gnl\|CDD\|273331	TIGR00907, Choline_transport_protein, amino acid permease (GABA permease). [Transport and binding proteins, Amino acids, peptides and amines].	1.5158e-134
NZ_CP023689.1\|WP_150501417.1\|5184787_5186137_-\|PrsW-family-intramembrane-metalloprotease	gnl\|CDD\|379143	pfam13367, PrsW-protease, Protease prsW family. This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Aflv_1074, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress.	6.69125e-51
NZ_CP023689.1\|WP_107909507.1\|5157923_5158997_+\|phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	2.2676e-179
NZ_CP023689.1\|WP_150501415.1\|5182148_5183234_+\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	7.30075e-34
NZ_CP023689.1\|WP_150501410.1\|5178566_5179346_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	5.54516e-17
NZ_CP023689.1\|WP_150501399.1\|5169677_5170082_+\|metallopeptidase-family-protein	gnl\|CDD\|240572	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein. The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	1.60861e-48
NZ_CP023689.1\|WP_150501412.1\|5179389_5180031_-\|GTP-cyclohydrolase-II-RibA	gnl\|CDD\|234745	PRK00393, ribA, GTP cyclohydrolase II RibA.	3.67239e-112
NZ_CP023689.1\|WP_150501408.1\|5177351_5178386_-\|GAF-domain-containing-protein	gnl\|CDD\|225113	COG2203, FhlA, FOG: GAF domain [Signal transduction mechanisms].	3.49738e-10
NZ_CP023689.1\|WP_150501393.1\|5159614_5160712_-\|Glu/Leu/Phe/Val-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	1.54917e-88
NZ_CP023689.1\|WP_150501414.1\|5180726_5181860_+\|5-amino-6-(5-phosphoribosylamino)uracil-reductase	gnl\|CDD\|180169	PRK05625, PRK05625, 5-amino-6-(5-phosphoribosylamino)uracil reductase; Validated.	1.05763e-44
NZ_CP023689.1\|WP_003949541.1\|5162388_5162595_+\|developmental-transcriptional-regulator-BldC	gnl\|CDD\|133390	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins. Proteins in this family mostly have a truncated helix-turn-helix (HTH) MerR-like domain. They lack a portion of the C-terminal region, called Wing 2 and the long dimerization helix that is typically present in MerR-like proteins. These truncated domains are found in response regulator receiver (REC) domain proteins (i.e., CheY), cytosine-C5 specific DNA methylases, IS607 transposase-like proteins, and RacA, a bacterial protein that anchors chromosomes to cell poles.	3.77068e-14
NZ_CP023689.1\|WP_030960273.1\|5180143_5180659_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.77642e-15
NZ_CP023689.1\|WP_150501404.1\|5173350_5175456_+\|VCBS-repeat-containing-protein	gnl\|CDD\|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	1.97585e-06

>NZ_CP023689.1|WP_150501400.1|5170194_5170734_+|hypothetical-protein
MRPLYVPVRLAATVVAVAAAAGCMSVGDDAGGGSAKPSHSAGQRGGEAPDGGSAVSGGGSGYGAHGQDGKPDKAKDKGKGKKKAGKSASPEASPSARASASVPAGGGRPPKPGQSENPGPTRPAEPTPTRTVEPEPTPTPEPTTATPTPTQAEPSSSAHEETGPQLGQREPAPAAGAPA
>NZ_CP023689.1|WP_150501399.1|5169677_5170082_+|metallopeptidase-family-protein
MRGRSWLLPGRVVPDNGRVLEMTREEFEELVAEALDRIPPELTRLMDNVAVFVEDEPPADDPELLGLYEGTPLTDRGEWYAGVLPDRITIYRGPTLRMCESRAEVVEETEVTVVHEIAHHFGIDDERLHALGYG
>NZ_CP023689.1|WP_150501397.1|5168074_5169646_-|metallophosphoesterase
MARVPAAVTKVLAHVPRAPRALARRYSTRRPLPTLELVTQPHPWTRALGLLTVVLLGAWLGLLIVGNVRAPVGPMNTTMTLRPSLTGGTKINVSPLGALTLDSHIAPVRLDVNVDQLDPERAQALVDHPERLSGLQDEVAQDVAHGTRDLAVRSCVAVVTGAAALGLAVYRRPRRALAAGGMALTLLAASGGTAYATWNPESVLEPKFSGLLSSAPSLVGNARSIVTEFDVYQKELARLVTNVTKLYDATSTLPAYAPDPSTIRVLHVSDIHLNPASWKIIASLVSQYKVNVIVDSGDTMDHGTAAENGFLDPVEDLGAPYVWVRGNHDSRLTQRYLENLKNVTVLDDGKARTIAGLRFAGIGDPQFTPDRSQVAGGDAANELAGARLATALRDQRAAGTPVDVAVAHEPVAVRQTDGEVPLALAGHLHHQEMEVMQYGTRLRLEGSTGGSGLRAVEGKHPDPIQTSILYFDRDTRRLQAWDEIELGGLGLTTAEVRRHLVEENQPGATDSPSPTGSSPGTSP
>NZ_CP023689.1|WP_150501395.1|5163637_5167615_-|ATP-dependent-RNA-helicase-HrpA
MSTHPAPALGPLAPRLNELSLRDAHRLGRRLEGARKIRKPEARAAVLAEIEAEVAKGEERIATRRTRLPAVSYPEQLPVSQKKDEIAAAIRDHQVVIVAGETGSGKTTQIPKICLELGRGVRGMIGHTQPRRIAARTVAERVAEELDTPLGESVGWKVRFTDQVNPDGTFIKLMTDGILLAEIQTDRELRAYDTIIIDEAHERSLNIDFLLGYLAQLLPKRPDLKVVITSATIDPERFARHFGDAPIVEVSGRTYPVEVRYRPLLEEDSEDADRDQITAICDAVEELQGEGKGDILVFLSGEREIRDTADALTRKQYRFTEVLPLYARLSHAEQHRVFQQHTGRRIVLATNVAETSLTVPGIKYVIDPGFARISRYSHRTKVQRLPIEPISQASANQRKGRCGRTSDGICIRLYSEDDFVARPEFTDAEILRTNLASVILQMTAAGLGDIEKFPFIDPPDHRNIRDGVQLLQELGAIDPAEKDVRKRLTQTGRKLAQLPVDPRLARMVLEADRNGCVREVMVIAAALSIQDPRERPADKQAQADQQHARFKDETSDFLAFLNLWRYVREQQKERGSSSFRRMCKQEYLNFLRIREWQDIYTQLRTVAKQMGIHLNEDDAPDDRVHVSLLAGLLSHIGMKDVKESKDSGPGARKDGGRNEYIGARNAKFAIFPGSALFKKPPRFVMSAELVETSRLWARVNAKIEPEWVEPLAEHLLKRTYSEPHWEKDQAAVMAYEKVTLYGVPIVAQRKVNYGRIDAEASRELFIRNALVEGDWRTHHKFFADNRKLLSEVEELEHRARRRDIVVDDETLFDFYDARVPEHVVSGAHFDSWWKRKRHEEPEFLDFEREMLIRESAEAVTKADYPDSWRQGQLKFRVTYQFEPGADADGVTVHLPLQVLNQVTDEGFDWQIPGLREELVTELIRSLPKPIRRNYVPAPNFARRFLDTSVPLQEPLTVTMARKLKRMVGVPFEADDFDWAKVPDHLRITFRIVDERRRKLAEDKDLETLKLRMKPKARQALSQAAAATASREGGESLERKGLTDWSIGTLTRVFETRRAGHPVKAYPALVDDGDTVSVRLFDTEAEQQQAMWKGTRRLILRNIPVNPAKFASEKLTNAQKIALSANPHGSVQGLFDDCAMAAADKLIGDFGGPAWDEESYRKLYDKVRAEIVDTTVRAVGQVQQVLAAWQAAERRLKDVRSPSLLANRTDVRGQLDGLVKPGFVTEAGLRRLPDLMRYLIAVDRRLQQMPTNVQRDTTRMEKVHEMRDEYAWLLEQMPQGRPVPQQVLDVRWMLEELRVSYFAHALGTAYPISDKRIVKAIDALAP
>NZ_CP023689.1|WP_107909503.1|5163133_5163328_-|hypothetical-protein
MAATARHETRALLRAHLSAASSYRHRTRHCPICHRLLRLAMEAGTRAYQPAPDEVTAEEAPSST
>NZ_CP023689.1|WP_003949541.1|5162388_5162595_+|developmental-transcriptional-regulator-BldC
MTARTPDAEPLLTPAEVATMFRVDPKTVTRWAKAGKLTSIRTLGGHRRYREAEVRALLAGIPQQRSEA
>NZ_CP023689.1|WP_125526532.1|5160963_5161806_+|hypothetical-protein
MPKVSSVIVPYATYLRVYEPLAAFPEPERGHWARYARRPDRPSYQDELRRSLADLLPTPPVPVPVQESGDAFVLEIDGVLCVCPWRTRLRGWQALGELADELPRPVLDAALPEFVRQQAAQDYERWLARNPDARPWIRTSTWQVPLHWFVLVSDEERRFDKGSGEIPPMLRYRTPMVQARRRVARALRTLKDTIDEGPLIDGLVDVGRWLEEFHPRSLVELDYGGLVHTLPAGELEDDHSAADVADGIEALRQGDGAGAGEAYARLVERWRSVRDRRSAN
>NZ_CP023689.1|WP_150501393.1|5159614_5160712_-|Glu/Leu/Phe/Val-dehydrogenase
MTDVTHGVLHTLFHSDQGGHEQVVLCQDRASGLKAVIAIHSTALGPALGGTRFYPYATEEEAVADALNLARGMSYKNAMAGLDHGGGKAVIIGDPDLIKSEELLLAYGRFVASLGGRYVTACDVGTYVADMDVVARECRWTTGRSPENGGAGDSSVLTAFGVYQGMRASAQHLWGDPSLRGRKVGIAGVGKVGHHLVEHLRAEGAEVVITDVREEAVGRILAAHPEGVTAVADTATLIRAEGLDIYAPCALGGALNDDTVPALTAKVVCGAANNQLAHPGVEKDIADRGILYAPDYVVNAGGVIQVADELHGFDFDRCKTKAAKIYDTTLAIFARAKTDGIPPAAAADRIAEQRMHEAATARRTR
>NZ_CP023689.1|WP_107909506.1|5159069_5159330_-|DUF3073-domain-containing-protein
MGRGRAKAKQTKVARQLKYNSGGTDLSRLANELGASTSNQPPNGEPFEDEDEEDDPYSQYADLYNDDDEDDEDDESGPTSQQRRGA
>NZ_CP023689.1|WP_107909507.1|5157923_5158997_+|phosphoribosylformylglycinamidine-cyclo-ligase
MSETSPAGASYAAAGVDIEAGDRAVELMKEWVKKTQRPEVLGGLGGFAGLFDASALKRYERPLLASATDGVGTKVDVARQMGVYDTIGHDLVAMVMDDIVVCGAEPLFMTDYICVGKVHPERVAAIVKGIAEGCVLAGCALVGGETAEHPGLLGEDDFDVAGAGTGVVEADRLLGADRIRTGDAVIAMAASGLHSNGYSLVRHVLLNQAGLALDAHIEEFGRTLGEELLEPTKIYSLDCLALTRTTDVHAYSHVTGGGLAANLARVIPDGLHAIVDRSTWTPAPIFDLVGRTGSVERLELEKTLNMGVGMIAIVPEESTDAALATLADRGVDAWVAGEITDRGEHTTGAALVGDYAS
>NZ_CP023689.1|WP_150501404.1|5173350_5175456_+|VCBS-repeat-containing-protein
MSRRVRARSFLVGLAALSAGSLTLAAPAAADTTPTPVQTVDGAWGIDFAGGILTTVETAPSGEPFVLNRPISADGGSAGDLSSRGYAGTYADGSHLKRVPCGAGSCAVLRAAGNGDVGYFFVVDGKEYARIRTTPNSYHSAEEPAVTGGRFVDVTGRYFVYETASTGKQYVDAVNDFRYQDVRLTRSVTAASVWGPRLWTPGSGAGAVTAYDLEQKKTVETLATGAPCTVKDLQAVGRWIYWNCGPSGAAGVYDRSAKKKIAVPSGPALVGDGYLVRHDRTTGKLLLTDFHTGTAAAPRAIADLPAGNTADQRRLTWAVDKFGGDIAYVGQDKAIRIVPSGVPSSALAVIEADPDDDYLNAKDKYWNSTWQFNKPASWKFTAKDSRGRAVYNSTGSGAEAEVGWNGKTDTGAYAYNGQYTWTLSATATEGSGTYTTSGTIGLSGGRQGHHDQGGHSYGELVTLNSSGGLTLHFTKGKGTFDWKESGSGWPAGTVAVPFGDMGSDRCSELLVRTPGGELRRYAGKCGSSYTPSSSHTSLGTGWNAYDVLTAPGDLTGDGRTDLLARQKSTGDVFVFANDGAGKLKARVKIASAWKGYTKLVGAGDLTGDGIGDVLAHDKYGALYRLDGAGNGKLKARVKIASQWGASYNAVVGVGDITGDGRNDLVARDSAGNLYRNSGNGNGTFGARVKIAGGWQGYKGIF
>NZ_CP023689.1|WP_150501406.1|5175504_5177055_+|amino-acid-permease
MTDDAIASGPSGGKMSDEERLAQLGYTQVLARRMSAFSNYAVSFTIISVLSGCLTLYLFGMNTGGPAVITWGWVAVGLMTLFVGLSMAEICSAYPTSAGLYFWAHRLAPPRTAAAWAWFTGWFNVLGQVAVTAGIDFGAASFLGAYLNLQFGFEVTPGRTILLFAGILVLHGLLNTFGVRIVALLNSISVWWHVLGVAVIVGALAFVPDQHRSASFVFGEFVNNTGWGSGVYVVLLGLLMAQYTFTGYDASAHMTEETHDASTAGPKGIVRSIWTSWIAGFVLLLGFTFAIQSYEGALTSPTGAPPAQILLDALGVTAGKLLLLVVVGAQLFCGMASVTANSRMIYAFSRDGALPFSHVWHTVSPRTRTPVAAVWLAAGGALVLGLPYLINVTAYAAVTSIAVIGLYIAYVIPTLLRVRKGEAFERGPWHLGRWSRIVGVVAVAWVGVITVLFMLPQVSPVTWETFNYAPVAVLVVLGFAWVWWLASARHWFLNPEHARNIAREAGRVGAPEPVDP
>NZ_CP023689.1|WP_150501408.1|5177351_5178386_-|GAF-domain-containing-protein
MDPSHNLMGSLDHVTASYTSTSPARPAHKVTAAHRADQLAAWVAFSLDEPPALKTLQDAAEELRDIPELPALLPRVTEAAMELLDAEFGNIQVVDPRDDSLVLVTQSGFGDEFLDHFAVVHDSHSVCGRAARQGAQAVTADVRDDQGLTPHQGVFRASGVRSVQSTPLVDHTGRLLGMISTHMSQPGRPSDQDLQIMELYGQLAGEVIARHLIVPDTAGHPHNGTVLDRRRPLLEQRGSTNGVTQWVYRVDEPYGPGGCRTYGIHPDQWRGRITTDHPDHDAEYAAALVARDLRAEWNIHRTGEARPVHIHVWRGWEGTHQDAAFTMEIQPDLNGHRHRAVDPA
>NZ_CP023689.1|WP_150501410.1|5178566_5179346_+|MBL-fold-metallo-hydrolase
MVAESSASEQVPVRVFGGPTALFEYGGLRVLTDPTFDAPGDYPLGGGRALTKTAASAGSVDDLGRIDVVLLSHDEHPDNLDVSGRALLADVPLTLTTPSGAKRLGGAARGLADWESVEVERPGGGVVTVTGVPALHGPGERAELEAVVGQVVGFVLTGDGLPTVYVSGDNAQLGPVREVAERFGPVDLAVLFAGAARTPALDRQLLTLDSDRAAEAARILDARRIVPVHFDSWAHFTEGREELEAAFTAAGLRERVQWG
>NZ_CP023689.1|WP_150501412.1|5179389_5180031_-|GTP-cyclohydrolase-II-RibA
MPDFTAATQRARVRVPLRFQDGYRADAELVTFHGLADGLEHVAVVLGNPAPGATPLVRLHSECLTGDVFGSARCDCGPQLREAVERIAERGGVLLYLRQEGRGIGLYNKLDAYALQDEGLDTYAANAALGLPEDARDYTAAAQMLAALGIGELDLLSNNPDKAEQLRALGVEVQGRVPTGVFATPDNVRYLRAKVLQTQHTLPLGDLSKVSAG
>NZ_CP023689.1|WP_030960273.1|5180143_5180659_-|MarR-family-transcriptional-regulator
MTTRWLTPEEQRAWRAYIGAVHLVEDALDRQLQQEAGMPHMYYSILSTLSESPERRLRMTDLAERLKITRSRLTYAVTRLEKDGLVLRENCRWDKRGSIAALTDEGMTVLEGAAPGHVETVRSVLFDRLSPEQVGQLEEIFSTVTEGFQGDAANTTGDDVPWRRRSAKSCS
>NZ_CP023689.1|WP_150501414.1|5180726_5181860_+|5-amino-6-(5-phosphoribosylamino)uracil-reductase
MPSYPYVLLSAAVSLDGYLDDTAPERLLLSSPADFDRVDEVRASVDAILIGAGTIRADNPRLLVNSAERRAARVAAGKPEYPLKVTVSASGELDAAANFWHTGGDKIVYTTEKGAERLRREPVAADVVALGPELDWRALLAHLREVRGVERLMVEGGGTIHTQLMTQGLADELQLVLAPLFVGDPEAPRLFGPGGYQGGRLRLLESRPIEDVVLMRYAPTAPGTGTLPCAADRHWLALACELAERCPPSETAFSVGAVVVAADGTELARGYSREGGDPVVHAEEAALAKIADGDPRLAAATVYSSLEPCTHRSSRPVPCARLILRAGASRVVTAWREPDTFVAGADGSGMLAAQGVDVLVLPEHEERAKAPNAHLLP
>NZ_CP023689.1|WP_150501415.1|5182148_5183234_+|SpoIIE-family-protein-phosphatase
MEEGRITYVRRFVRSLPALLIALGAAYDFATPLDFTGAPFLTAAPLVAAPLYSQRGTILTGVAAVLVLLVLRILRGGLHKAEAVTELVTVIVVSVLAVLVNLLVRRGQERLASVREIAEAAQRAVLPEPAERIGGFQIAARYEAAQEGASIGGDLYAVQDTPHGVRLIVGDVRGKGMGAVGAVAVVIGAFREAAEQEVTLEAVAQRLERALARERTRSEGIEAREGFTTVVLAELPHGDAVVRLVNRGHPAPLLLYADGTIRPLPATEPALPLGMGELGTWPDRADEAGFPGGATLLLYTDGLSEARDAGGRFYDPGTGLAGRAEVLREPGALLGVLSVEVRRHSGGGMADDMALIAVRRP
>NZ_CP023689.1|WP_107909491.1|5183636_5184662_+|M23-family-metallopeptidase
MASNRPAPQAPFVPSQRDTDTFGYDRLRTDEGPFEEWNPTAESIRPVRGRHRVSKQRGGGLARSSTVLGVGVIAAVGAGGMASANSGKPPVAITMPDLPLISDDSSEPADDAATAFSTMGETTEQTAQGTSDAGEALRSRIIAQAELQQDQIDNKAAAAAVAAAQKEAADAAAKAEKEAKAKAAAAKAAAEEEARKKAEAERLAELAKQYTLPTSSYTITSTFGQAGAYWSSGYHTGLDFAAPTGTLIKAIHSGTVTFAGWDGSYGYKTEITLDDGTELWFAHQSSISVSVGQKVNTGDVIGRVGATGNVTGAHLHLEVHPGGSTSGIDPMAWLQGKGLTP
>NZ_CP023689.1|WP_150501417.1|5184787_5186137_-|PrsW-family-intramembrane-metalloprotease
MATCPPYPTHPTGPTGGALRHAHWWQRRWVRYGALSTLLALSGLVILALVREQTGTEGFLVGLGLAVLPVPLLVASFRWLDRVEPGPWRNLLFSFAWGACAAALIAIVANSFATRWIATATADPSHADTLGATVIAPVVEELAKAAAVLLVFLFRRRDFTGIVDGVVIAGVTATGFAFTENILYLGTAFGTDQLTGDRGIASVTAATFFVRVIMSPFAHPLFTVLTGIGFGIAALSGDRQHVRRVLLPLLGLLLAMGMHAMWNGSSAFGEYGFFAVYATLMVPAFGLLTWLVIWTRQRELRTVREELPAYVVAGWLSPGEPFALGSMRERRVARQYARRHGGRTAARTVAQYEAYATSLAFLRHRGRRGRAGADFVVREQELLHALWHRREFARPALEHAAAAQSWRGHEHGYGHPHVAPMPVYWQSYGQVEGPMYGPAPYPAYNPYRT

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Crispr_ID: NZ_CP023689_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_8

5299967-5300068

Orphan

Consensus_repeat	Method
GTCGCGCAGTTCCCCGCGCCCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_8

>merge|NZ_CP023689|8|5299967-5300068|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCTAAAAGAAGGGCGTTGCAGTGGGCCTGCGCCGCGACGTGACCGCACCCGTCACAACCGTTGCGCAGTTCCCCGCGCCCCT

>NZ_CP023689|8|7|5299967-5300068|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCT	AAAAGAAGGGCGTTGCAGTGGGCCTGCGCCGCGACGTGACCGCACCCGTCACAACC
GTTGCGCAGTTCCCCGCGCCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_125525125.1\|5304948_5305428_+\|DUF2000-domain-containing-protein	unknown	unknown	gnl\|CDD\|378176
NZ_CP023689.1\|WP_150501541.1\|5302446_5304165_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378931
NZ_CP023689.1\|WP_150501537.1\|5297837_5298911_-\|glycoside-hydrolase	unknown	unknown	gnl\|CDD\|366353
NZ_CP023689.1\|WP_093746491.1\|5304143_5304950_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP023689.1\|WP_107906135.1\|5300445_5301783_+\|D-inositol-3-phosphate-glycosyltransferase	unknown	unknown	gnl\|CDD\|132490
NZ_CP023689.1\|WP_150501533.1\|5294926_5295619_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NZ_CP023689.1\|WP_150506814.1\|5299129_5299897_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	unknown
NZ_CP023689.1\|WP_062723775.1\|5309546_5310308_+\|phosphoglyceromutase	unknown	unknown	gnl\|CDD\|184519
NZ_CP023689.1\|WP_167537752.1\|5293669_5293834_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150501525.1\|5291174_5291552_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
NZ_CP023689.1\|WP_150501543.1\|5305430_5307971_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|379328
NZ_CP023689.1\|WP_150501535.1\|5296253_5297555_-\|SpoIIE-family-protein-phosphatase	unknown	unknown	gnl\|CDD\|369272
NZ_CP023689.1\|WP_150501539.1\|5301775_5302285_+\|YbjN-domain-containing-protein	unknown	unknown	gnl\|CDD\|371210
NZ_CP023689.1\|WP_150501531.1\|5294081_5294816_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP023689.1\|WP_107906288.1\|5310480_5310981_-\|lamin-tail-domain-containing-protein	unknown	unknown	gnl\|CDD\|376421
NZ_CP023689.1\|WP_150501547.1\|5311425_5311695_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_037864434.1\|5295754_5296093_+\|DUF2516-family-protein	unknown	unknown	gnl\|CDD\|378483
NZ_CP023689.1\|WP_150501527.1\|5291677_5292613_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|223528
NZ_CP023689.1\|WP_150501545.1\|5308077_5309373_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NZ_CP023689.1\|WP_150501529.1\|5292805_5293603_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|131480

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_125525125.1\|5304948_5305428_+\|DUF2000-domain-containing-protein	gnl\|CDD\|378176	pfam09391, DUF2000, Protein of unknown function (DUF2000). This is a family of proteins of unknown function. The structure of one of the proteins in this family has been shown to adopt an alpha beta fold.	1.14923e-60
NZ_CP023689.1\|WP_150501541.1\|5302446_5304165_+\|hypothetical-protein	gnl\|CDD\|378931	pfam12708, Pectate_lyase_3, Pectate lyase superfamily protein. This family of proteins possesses a beta helical structure like Pectate lyase. This family is most closely related to glycosyl hydrolase family 28.	1.39755e-16
NZ_CP023689.1\|WP_150501537.1\|5297837_5298911_-\|glycoside-hydrolase	gnl\|CDD\|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	1.76434e-24
NZ_CP023689.1\|WP_107906135.1\|5300445_5301783_+\|D-inositol-3-phosphate-glycosyltransferase	gnl\|CDD\|132490	TIGR03449, mycothiol_MshA, D-inositol-3-phosphate glycosyltransferase. Members of this protein family, found exclusively in the Actinobacteria, are MshA, the glycosyltransferase of mycothiol biosynthesis. Mycothiol replaces glutathione in these species.	0
NZ_CP023689.1\|WP_150501533.1\|5294926_5295619_+\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	1.83505e-05
NZ_CP023689.1\|WP_093746491.1\|5304143_5304950_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	2.95656e-22
NZ_CP023689.1\|WP_062723775.1\|5309546_5310308_+\|phosphoglyceromutase	gnl\|CDD\|184519	PRK14120, gpmA, phosphoglyceromutase; Provisional.	0
NZ_CP023689.1\|WP_150501525.1\|5291174_5291552_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.31714e-33
NZ_CP023689.1\|WP_150501543.1\|5305430_5307971_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	1.91254e-26
NZ_CP023689.1\|WP_150501535.1\|5296253_5297555_-\|SpoIIE-family-protein-phosphatase	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.99597e-37
NZ_CP023689.1\|WP_150501539.1\|5301775_5302285_+\|YbjN-domain-containing-protein	gnl\|CDD\|371210	pfam10722, YbjN, Putative bacterial sensory transduction regulator. YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabilizer for some other unstable proteins. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	2.37061e-17
NZ_CP023689.1\|WP_150501531.1\|5294081_5294816_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.59504e-14
NZ_CP023689.1\|WP_107906288.1\|5310480_5310981_-\|lamin-tail-domain-containing-protein	gnl\|CDD\|376421	pfam00932, LTD, Lamin Tail Domain. The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated hydrolases of the metallo-beta-lactamase,synaptojanin, and calcineurin-like phosphoesterase superfamilies.	7.06449e-25
NZ_CP023689.1\|WP_037864434.1\|5295754_5296093_+\|DUF2516-family-protein	gnl\|CDD\|378483	pfam10724, DUF2516, Protein of unknown function (DUF2516). This family is conserved in Actinobacteria. The function is not known.	6.23389e-31
NZ_CP023689.1\|WP_150501527.1\|5291677_5292613_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|223528	COG0451, WcaG, Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	4.63307e-36
NZ_CP023689.1\|WP_150501545.1\|5308077_5309373_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.36727e-95
NZ_CP023689.1\|WP_150501529.1\|5292805_5293603_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	3.30134e-20

>NZ_CP023689.1|WP_150506814.1|5299129_5299897_-|class-I-SAM-dependent-methyltransferase
MGTVTRGTTNPNRLRRMDRWIAHTHGSALRRGDDPVAVDLGYGAAPWTAVELLGRLRVVAPRVRVVGLEIEPARVVAARPYERDGLVFRHGGFEIPGSQRPLLIRAANVLRQYDEGEVAGVWERLCGRLASGGLLVEGTCDEVGRRHVWVALGPEGPRTVTFAARLGSLERPSNLAERLPKALIHRNVPGEPVHAFLRDFDRAWAAAAPYASYGARQRWIRAVRDLAVDWPVVDGAGRWRQGEVTVRWGALAPRG
>NZ_CP023689.1|WP_150501537.1|5297837_5298911_-|glycoside-hydrolase
MGKRGLIATAVTVVCAVTVLAAPGTAFAAPTPSPSSSPSASPTPVSNKELEDVRKKLEKLYHDAAVATDEYNAAEEAAEKQSAEIVSLAKKIVKGQEKLAELKKRAGSAAAAQYRSGGLPDEAKLMLSDDPRDFLDSAGRVIQGQRATKGLLGEMTRTQQDLEQYASDASAQWQKLEAGRKAKAAAQKKIEKQIKAAEQLESQLEKEEKERLAQLEEDAAHKAQTAWLDSGVLDDIKGKASAQGRKAVEYATAQLGKPYEWGAEGPKTYDCSGLTSQAWASAGSGIPRTSQEQWKQLERIDIEDMRPGDLIIYNADASHVAMYIGDGAIIHAPRPGRTVTIAGAGSMRILGVVRPDA
>NZ_CP023689.1|WP_150501535.1|5296253_5297555_-|SpoIIE-family-protein-phosphatase
MPVPVPRQRAIPAVETGQAPAASPGGTTREVAPRKDETVENSTHTALTLLLIEDDPGGSAMVPELHDSAGRPIRVRTARNLTEAGRLLTDDVHCILLDLALAAPGRGVDDDELAVLRHVLELAPRHAVLALTASGDAERGAEAVRVGAQDYLFRDELDGRLLSRAIRYAVERKRSDTAERRLAEGRLRAQENRRLERGLLPTPLLEGSSLRFAARYRPGRSRALLGGDFYDVVRTADGTVHAMIGDVCGHGPDEAALGVELRIAWRALTLAGLCGDALLGTLQKVLEHERADDEIFATLCTVDIAPDGRRAGLCLAGHPSPLLARPGRAAQLLPYDNNGPALGLLPKARWPRMEVKLGAEWSLMLYTDGLIEGRIGQGRERLGQDGMVEMVRRQLSEGLRGEALLRAAVNEVRDLNGGELTDDVAVLLLDRGA
>NZ_CP023689.1|WP_037864434.1|5295754_5296093_+|DUF2516-family-protein
MLMQGFVGFMWLLSMALILFSGFALIDAAIRREDAYRAADKQSKAFWLIILGLAFVVNLIFNILSFLPIIGLIATIVYMVDVRPAIKGLPGGGRSRKGSSSDGPYGPYNGGR
>NZ_CP023689.1|WP_150501533.1|5294926_5295619_+|hypothetical-protein
MAITDDLRKTFSDPTPLYFAAGTADLALQQARKVPALVEQLRSEAPARFEAVRSTDPKAVQEKAATRAKEAGAKAKEAQETLQTKVNEFVSSLDADVKKFGSNLDADVKKFGSSIDADLKKFGESAQDFALRTIGVAAEYAVKAREAYEKVAEHGEQTVKTWRGEAAEEIEDLAIAVEPKAEPVEVKEDKAAAKPAEAKPAAEAAPAKKAPTKKAPARKPAAKKTTPPAK
>NZ_CP023689.1|WP_150501531.1|5294081_5294816_+|helix-turn-helix-domain-containing-protein
MASLNVGNLGDYLREQRRNAQLSLRQLADAAGVSNPYLSQIERGLRKPSAEVLQQVAKALRISAETLYVRAGILDAERDRDEVETRAVILADPTLNERQKQVLLQIYESFRKENGFGISVEVDGHSVADRDADQTVVDAVRSVGSDPGSQGSPDPEVSGDSDARSDGTADARGDDADVRRSRTTRKNSTADGGRESAARRNRTTRTTRSSTRSTGSTGSTRTTRTSDGSDADPENPTDPQQSAG
>NZ_CP023689.1|WP_167537752.1|5293669_5293834_-|hypothetical-protein
MKRRAIAVRAAVVAVLATVVAGLALFAVPAADWDGHGNIERNEWNIPLTNLRVL
>NZ_CP023689.1|WP_150501529.1|5292805_5293603_+|alpha/beta-fold-hydrolase
MPTSSAYAKVNGVEMYYEIHGAARDGGTGAAGPGAAARRPLVLLHGGVTTIGMSFGAVLPALAADRYIVAPELQGHGHTADTDRALTVPNLASDVVGLLDELGIPQADFLGYSLGGLTALEIGIRHPDRVGRLVLAATQYHQDGIHDEVHAGDFDSPRLPSQADFQEMAEAYAACAPHPEHYQDFLGKISVAANAPLPWTADDLRTVQAPTLLLIGDRDFVRVEHAAEMQRLIPGARLAVLPATDHMALMRRTPLLLPLLNEFLD
>NZ_CP023689.1|WP_150501527.1|5291677_5292613_-|NAD-dependent-epimerase/dehydratase-family-protein
MRVFVAGGTGVIGRRLVPRLVERGHQVTATTTSAAKLGLVEGMGATGVVMDGLDAMSVGEAVAAARPDVIVHQMTAISAPHSGKPDIRHFDRWFATTNRLRTEGTDHLLAAAEATGVPHVVAQSAAIWNGVREGGWVKTEEDPLPVETGKLRELGEAVRHIQEAVLKADGTVLRYGGFYGPGATDDQVELVRKRQFPLVGGGTGYCSWVHLDDAASATLLAVEQRARGVFNIVDDEPAPASEWLPYLAECAGAKHPLRVPKWLARLLAGDVVVTMMTEGRGFSNAKARRELGWEPRYPSWRQGFREELVGT
>NZ_CP023689.1|WP_150501525.1|5291174_5291552_+|helix-turn-helix-transcriptional-regulator
MTRRRQDPNVCGVTAAIAVIDGKWKTLLLWLLESGPHRPAELRRRAPGLSEKVLTQALREMESDGLVHREVYDVLPLKTVYSLTDFGRELADALAPLADWGHRRLERLTETQPRLERLTETSSAS
>NZ_CP023689.1|WP_107906135.1|5300445_5301783_+|D-inositol-3-phosphate-glycosyltransferase
MSQYVSRLGRRSPSAPSRLRLHRRPRRVAMLSVHTSPLHQPGTGDAGGMNVYIVELAQRLAAINIEVEIFTRTTATDLPPVVELAPGVLVRHIDAGPYEGLNKEDLPAQLCAFTHGVMQAWAGHRPGYYDLVHSHYWLSGHVGWLAAQRWGAPLVHAMHTMAKVKNANLADGDTPEPAARVIGETQIVAAADRLIANTSEEAEELVRHYAAARDKVAVVHPGVNLTRFAPADGRAAARARLGLPQDALIPLFAGRIQPLKAPDILLRAVAVLLDEHPELRSRILVPIVGGPSGSGLAKPEGLQKLAARLGIADVVRFRPPVGQEQLADWFRAASLLVMPSYSESFGLVAIEAQAAGTPVLAAAVGGLPVAVRDGHTGFLVQGHNPAEYARVLRAFADEPHLTARMGEAASRHAQSFGWDTAAAATADVYTAAAQAHRRRVRSHHG
>NZ_CP023689.1|WP_150501539.1|5301775_5302285_+|YbjN-domain-containing-protein
MGDAQDVQRAAQVVEGALKDAELEWESPAPGNYVVKLPGTRKLSTTVSLLVGRHSLSLNAFVIRHPDENEPGVHRWLLERNLKLYGVSYAVDRLGDIYVTAKLPLAAVTVDEIDRLLGQVLEAADGAFNTLLELGFASAIRKEYEWRVARGESTRNLDAFTHLIQRPSE
>NZ_CP023689.1|WP_150501541.1|5302446_5304165_+|hypothetical-protein
MGNAHLTRRTLLGGATAVALGATAAGVAHATTAKPHSTGAPLTGPRTPPSATPQVPPIWREFNRTPYTHPQIPYIGRAGHRGGARRFPRPRVVADVRDFGAVADGTTDSAPAINRAIAAAGRAGGGTVTIPPGTFRIDDVIRIGHSNVVLRGAGSTRTKLYATRNLTELIGPYGSRYGGDKSSWSWAGGLIWLAPTARWDSLVAAIRAKAWPFEGWTGNRRDEWHPLTTVAPARQGSWTVTVTDPSALRPGALVLLRLSDDAGHTLLEHMSGGGPGPEAYTWDDKTKLTSYVPYEWPVRITAVKGRKVTLERPLPLDVRPEWDPQLTTHADELTGSGVEGLTLEAMETPQQPHLLDKGYNGVTFQCAYDCWADDVTVRHVDNGFGLVAASACTLRRTRVAGRGSHHPYFCREGSHDNLIEDFTIEARTTPAPSGTQLHGINVEGLSSYNVWSRGDMRMGTFDSHRGLPFANVRTDITVDNNGRHGGDASAGPLFGARFTHWNVRVTNARAGMIRLDGLAPYSATVGLNEVREFDQIDVPDFTGDLHSRLELYGTTDAVHPPNLYDAQRALPR
>NZ_CP023689.1|WP_093746491.1|5304143_5304950_-|AraC-family-transcriptional-regulator
MAAARDRQEVSAWRPSVPGVTEVFHAHFTEYAYPMHVHEAWTLLIVDDGAVRYDLDRHEHGTPHDTVSLLPPHVPHNGSPATPHGFRKRVLYLDSTRLADDLIGPAVDSPDLADPVLRLRVGQLHAALAQPGDELEADSRLTLIGDRLRAHLRPRTLTDVPRRDPVLARRLRELLDERVVPGIGLDEAAAVVQAHPAHLVRAFSTAYGIAPHQYLMSRRVDRARRLLLEGRSPAEVAVATGFYDQSHLSRHFRKLVGVPPGRYRGSAR
>NZ_CP023689.1|WP_125525125.1|5304948_5305428_+|DUF2000-domain-containing-protein
MQRTYKTEPYDGRQSHPMSTEAPVRFDTKIAVLLREDLEPWQRLNVTAFLVSGLGTQVPEVIGDPYEDADGVPYLPMFRQPVLVFETTKETLTTAHARALSRSLPRAIFTSDLFTTGNDRDNRAAVRAVPTNELDLVGMAVYGPRNAVDKVIKGARMHP
>NZ_CP023689.1|WP_150501543.1|5305430_5307971_-|tetratricopeptide-repeat-protein
MTDSSGLIFVSHAGHDGQWAEWVAWHLREAGYEIELDLWHWRTGEDFVKKMNEALERASAVVALFSPQYFAPGRYTEEEWTAAVAGRDRFVPLVVEPLEVGQLPAILRPRIRRELHDLEEATALEALLEAVRGREIPTTSPAFPGKAGKAGKGTKSAKRSGPAAPQGLQPRFPSALHDPAVWDVRQRGRNPHFTGRDEIIEKVRGGLLGERRSAVRVLHGPGGVGKTQMALEYAHRFAGQYDLVWWVDAEQVEQVPTRYAELAARVDVAKPDAGAEVNAQYALEYLRTSDRWLIVLDNAEDPRQLRTWLPEGPGHVLITARDPAWSKVVPGLALGMFSREESLGYLNRQLPTLSSGTADALADALGDLPLALAQAAGALGEGTPPDHYLQLLRTNTAELLNDGEVYDYPVSVAATVTIAAERLDAGRPEAAALLRLAAFLGPEPIPTKWLVEARGALTSVPGDPNDFRWPRNALQPLAQYGLAVVGPDVFQVHRLTQAVVRQASAEQAGGPVQDVAALLATLDPGDPELPETWPEWASLTQHLTATLDAIIGRAELRPKLLKAAIYLVRNAQPDASHHLAETLHRTWRASLGEDDPDTLRAAQLMAVALNDMQRYEESLPLIEDLLERRRRVLGEEHPDTLSSTHDLGVILGGLGREAEAYTILRDVVARREEALGENHIDALRSVANYGFSLMQVERLDEAHQVLTDALARYRRALNEDHPAALDASSYLGLVLSHLGRHVEALHVHSEVLTRRRQLLGDRHEDTILSASNLARALIDTGQYARAEPLLRSTRTRARESLGNDHRLYSNLTLELADALHRQGKTHDAQRLRASLNRKKLPKKRPR
>NZ_CP023689.1|WP_150501545.1|5308077_5309373_-|MFS-transporter
MPLAAVRRATRETVAGLPREFWWLWTSTLVNRLGAFVATFMALYLTLDRGYSASYAGLVASLHGLGGVVSSIGAGVMTDRLGRRPTLLVAQASTAVSVAVLGFVHHPVAIAAVAFVVGAASNASRPAVQAMMADIVRPEDRVRAFSLNYWAINLGFAVSSMAAGFIAEVSYLAGFLIEAGMTAVCAVVIFVKLPESRPEKSDTGKGEEEVGLGTVLRDGRFMAVVGLSFLVALVFQQGSVGLPIAMGDAGFSPADYGLAIAINGILIVALQIPVTRFIERRDAGRILIVSSLLAGYGFGLTAFAGSVGVFALTVCVWTLGEMLNAPTQTGLVVRLSPAHGRGRYQGMYTLSWSVAALIAPLMSGFVIDHLGAEWLWGLCAVVGTAAAIGYGALTRYVGAESAATKETVEITKSAETDVSPVPGTEPDVRTA
>NZ_CP023689.1|WP_062723775.1|5309546_5310308_+|phosphoglyceromutase
MADAPYKLILLRHGESEWNAKNLFTGWVDVNLNEKGEKEAVRGGELLKDADLLPDVVHTSLQKRAIRTAQLALESADRHWIPVHRSWRLNERHYGALQGKDKAQTLAEFGEEQFMLWRRSYDTPPPPLEDGTEFSQSDDPRYATIPPELRPRTECLKDVVVRMLPYWYDGIVPDLLTGRTVLVAAHGNSLRALVKHLDGISDADIAGLNIPTGIPLYYELDADFNPVTPGGKYLDPEAAAAAIEAVKNQGKKK
>NZ_CP023689.1|WP_107906288.1|5310480_5310981_-|lamin-tail-domain-containing-protein
MSASASVSARRLAAAALAAGALVSVVTLPASAADHPRHERPKVQISDVQYDSPGRDDRSNRSLNREWVEITNTTRHTVNLDGWTLEDEDGHTYTFDHYRLEGRATVRVHTGYGRDTDSDLYQDSRRYIWDNRSDTATLRNDRGRFIDNESWGYDRHHGGHHGGYRR
>NZ_CP023689.1|WP_150501547.1|5311425_5311695_+|hypothetical-protein
MSGRVKAWLAGGWLVLVVAGWAFTESINDGIEPTSGPRPEPSSSSSPKCPATALPTPTPSTGPDRDASDFYAESEADVTVRDVACIVSD

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Crispr_ID: NZ_CP023689_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_9

5384010-5384103

Orphan

Consensus_repeat	Method
GCGCAGTTCCCCGCGCCCCTGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_9

>merge|NZ_CP023689|9|5384010-5384103|CRISPRCasFinder
GCGCAGTTCCCCGCGCCCCTGGGGGGTTGCGGGGCCGTCGGTTGTTTGGTTGGCGCTTCGATGGCGGCCGTGCGCGGTTCCCCGCGCCCCTGGG

>NZ_CP023689|9|8|5384010-5384103|CRISPRCasFinder
GCGCAGTTCCCCGCGCCCCTGGG	GGGTTGCGGGGCCGTCGGTTGTTTGGTTGGCGCTTCGATGGCGGCCGT
GCGCGGTTCCCCGCGCCCCTGGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_107906057.1\|5390236_5391880_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP023689.1\|WP_150501630.1\|5393228_5393444_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150501623.1\|5385234_5385930_+\|copper-homeostasis-protein-CutC	unknown	unknown	gnl\|CDD\|225684
NZ_CP023689.1\|WP_150501627.1\|5387669_5389718_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|226482
NZ_CP023689.1\|WP_150501621.1\|5384268_5384943_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	unknown	unknown	gnl\|CDD\|274422
NZ_CP023689.1\|WP_150501634.1\|5396702_5398343_+\|solute-binding-protein	unknown	unknown	gnl\|CDD\|270371
NZ_CP023689.1\|WP_107906281.1\|5390011_5390191_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107906064.1\|5376472_5377375_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_CP023689.1\|WP_150506824.1\|5382158_5383241_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP023689.1\|WP_150501613.1\|5375478_5376414_-\|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl\|CDD\|235467
NZ_CP023689.1\|WP_150501619.1\|5383292_5383943_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226789
NZ_CP023689.1\|WP_150501625.1\|5387191_5387590_+\|ANTAR-domain-containing-protein	unknown	unknown	gnl\|CDD\|198080
NZ_CP023689.1\|WP_150501632.1\|5393833_5396494_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|379300
NZ_CP023689.1\|WP_150501617.1\|5378805_5381025_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|379062
NZ_CP023689.1\|WP_150501629.1\|5392030_5393251_+\|TIGR00645-family-protein	unknown	unknown	gnl\|CDD\|180607
NZ_CP023689.1\|WP_107906063.1\|5377430_5377817_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150506822.1\|5377855_5378080_+\|DUF4031-domain-containing-protein	unknown	unknown	gnl\|CDD\|379076
NZ_CP023689.1\|WP_150501611.1\|5374622_5375453_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381314
NZ_CP023689.1\|WP_150501615.1\|5378311_5378740_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107906062.1\|5381571_5382045_-\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150501634.1\|5396702_5398343_+\|solute-binding-protein	gnl\|CDD\|270371	cd13653, PBP2_phosphate_like_1, Substrate binding domain of putative ABC-type phosphate transporter, a member of the type 2 periplasmic binding fold superfamily. This subfamily contains uncharacterized phosphate binding domains found in PstS proteins that serve as initial receptors in the ABC transport of phosphate in eubacteria and archaea. After binding the ligand, PstS interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The PstS proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.49208e-38
NZ_CP023689.1\|WP_150501623.1\|5385234_5385930_+\|copper-homeostasis-protein-CutC	gnl\|CDD\|225684	COG3142, CutC, Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism].	1.62297e-23
NZ_CP023689.1\|WP_150501627.1\|5387669_5389718_-\|AAA-family-ATPase	gnl\|CDD\|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	1.06368e-66
NZ_CP023689.1\|WP_150501621.1\|5384268_5384943_+\|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	1.75908e-17
NZ_CP023689.1\|WP_107906057.1\|5390236_5391880_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	4.02085e-108
NZ_CP023689.1\|WP_150506824.1\|5382158_5383241_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.77957e-18
NZ_CP023689.1\|WP_150501613.1\|5375478_5376414_-\|N-acetylmuramic-acid-6-phosphate-etherase	gnl\|CDD\|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	1.0534e-161
NZ_CP023689.1\|WP_150501619.1\|5383292_5383943_-\|hypothetical-protein	gnl\|CDD\|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	2.05654e-49
NZ_CP023689.1\|WP_150501625.1\|5387191_5387590_+\|ANTAR-domain-containing-protein	gnl\|CDD\|198080	smart01012, ANTAR, ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.	1.41914e-14
NZ_CP023689.1\|WP_150501632.1\|5393833_5396494_-\|DNA-binding-protein	gnl\|CDD\|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	3.66037e-43
NZ_CP023689.1\|WP_150501617.1\|5378805_5381025_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	1.5088e-06
NZ_CP023689.1\|WP_150501629.1\|5392030_5393251_+\|TIGR00645-family-protein	gnl\|CDD\|180607	PRK06526, PRK06526, transposase; Provisional.	2.30579e-83
NZ_CP023689.1\|WP_150506822.1\|5377855_5378080_+\|DUF4031-domain-containing-protein	gnl\|CDD\|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	2.11758e-25
NZ_CP023689.1\|WP_150501611.1\|5374622_5375453_-\|aldo/keto-reductase	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	6.01091e-114
NZ_CP023689.1\|WP_107906064.1\|5376472_5377375_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	9.03351e-68
NZ_CP023689.1\|WP_107906062.1\|5381571_5382045_-\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.35154e-19

>NZ_CP023689.1|WP_150501619.1|5383292_5383943_-|hypothetical-protein
MPDLDTDALRTRFTRTLDSARSPLTAPAPTPYADALLTRWQEPQRRYHTLAHLTAVLDRVDELAGYADDPDVVRLAAWFHDAVYLPDRSENEERSARLAERALTEAGVPADRTAEVARLVRLTVTHDPAPDDRDGQVLCDADLAILAAPPSTYAAYTAAVREEYHFVPSDAFREGRAAILRQLLDLPSLFRTPHGRKEWEATARYNLAGELEMLSP
>NZ_CP023689.1|WP_150506824.1|5382158_5383241_-|GNAT-family-N-acetyltransferase
MTEAVASCVALLRSAADRDWEAVPAGRLKWSCHRTAFHIAEDLVGYAGQLAARAQDAYVPFEITLDEGTDNEGLIQVVEMGGALFSAAIRATPHEVRAFHPYPFRSANREGYAAMGIAEVLLHTHDIAEGLGLTYEPPAELAEFVLTTIFPHVRPGPDHWRTLLWATGRGDLPGRPPVTEWRWNNNLVIPTDRLTLQGVTPAAATDLHTGGDGGFEWVDGGPFQGTRDAAGMVVKAYGEGVHRPEWGLFVLVRREDGRAIGGIGFHGVPDEEGHAEVGYDLTEAARGQGYATEALRALSDHSLTGDEAHGLIAAIHEDNAPSQGVATRAGYVRASVEEERTAYEERDMDRELRLYVRRSA
>NZ_CP023689.1|WP_107906062.1|5381571_5382045_-|carboxymuconolactone-decarboxylase-family-protein
MSARLNALEIPTVGKFVKYIASAGKVIHDSSLPVATQNMVTLRASQINGCGFCTDMHFKDAVAAGEDTVRLNLVAAWREATVFTEAERAALELTEAGTRIADAAGGVPDDVWENAAKHYDEEQLGALVSLVALINAFNRMNVIVQQPAGSYQPGQFA
>NZ_CP023689.1|WP_150501617.1|5378805_5381025_+|tetratricopeptide-repeat-protein
MVFQAGRDMYVRLDAASRSTAVVLPVVPLQDAVQPLFIGRGGEQQQLESLFSSSSESTAIVVSGLAGVGKTALSWHAAARAVERGLFPGGAVMVNLHGYEPELALEAAQVFGPLLRALGQSPADIPARAGEQAAAYHHLLAQRAAGNEPVLLILDNASKAGQITDLLPVSATHRVVVTSRDLLAPRIRGARSVRLTALPPAQAAELLAASVIRHTADKVMPAHQESISALAALCGNLPLALEIVSALLAEAADPGQLVEDLADTHTRLSFLDDGERAVRAAFDLSFVRLNGDEATCFTFLSLNPGPELATDAAAVLFDRPQLQTRRALSALRRAHLLEPGTTSDRWSMHDLLRLYAAEVLAQRETAQTRDEALERILRHYSARVRTEERCFYPPQQTGAVHDERWVTRRQQAIDWFDIELPNLVGAVSRAAAMGFADLSVRTAAHLFHYFDHYRLWPEWEATHRAALVAARQSGDEVGQAQLLCSLGLLLREQHRTEEARQAQSESLELARRTCDTVREGWAAVHLGGVLHDMRRYEDAATILGEAVSVFAGLGDAHGEAWAHQNLGSVHAALGRTNDAIIAYEGSIRVRAEAGDSYGAVFTWTQLGAAYAAAGQLEQAGDCLQRSMDLCRHLGYDDELALAQGLMSSVCTFMKRSEEADEHRNASFASIRAVSDLHKSVIAFSELAAQQAAVGDTSGAGFSYREALDLLGVEEDPQRSLSDQVADEIHRAEIRTTSAT
>NZ_CP023689.1|WP_150501615.1|5378311_5378740_+|hypothetical-protein
MDAVLSATGAAVVRAISQDNGDRLSQAVVELWQRFRPHEAAGIEADLMELRQAAAEVGSSPDASGWRALEGLWRLRFRQLAQSNSAGTAQLLRFLDQRLAPLLAAAEREAPHPVTLEARASGHAVVFQAGRDQRVTYRDSDS
>NZ_CP023689.1|WP_150506822.1|5377855_5378080_+|DUF4031-domain-containing-protein
MWSHLVSDLSYDELHTFAEKLGVPRRAFERDHYDIPSHRYADAVRAGAVEVSSREVVRLLQGAGLRRPKGRDWG
>NZ_CP023689.1|WP_107906063.1|5377430_5377817_+|hypothetical-protein
MEPVTPLEQALHTARALVLADLVAGEAAEADVVSLVEEAVVQRRWWVEQWPDGVEYVAGLVAQDVQDALLDRFGRWPLCPVCGDGDPHALEVEPELGPDPHWVCHQAGVKVAAVGSLGPAAAGGTPAS
>NZ_CP023689.1|WP_107906064.1|5376472_5377375_-|MurR/RpiR-family-transcriptional-regulator
MPHEVKETFDRAPAPAALAAKVRTLAPSMTRSMQRVAEAVANDPAGCAALTVTGLAELTGTSEATVVRTARLLGYPGYRDLRLALAGLAAQQQSGRAPAITTDIAVDDPIADVVAKLAYDEQQTLADTAAGLDTVQLGAAVSAAATARRIDVYGVGASGLVAQDLAQKLLRIGLIAHAHSDPHLAVTNAVQLRAGDVAIAITHSGSTGDVIEPLRVAFEHGATTVAITGRPDGAVTQYADHILTTSTARESELRPAAMSSRTSQLLVVDCLFVGVAQRTYDTAAPALAASYEALAHRHRR
>NZ_CP023689.1|WP_150501613.1|5375478_5376414_-|N-acetylmuramic-acid-6-phosphate-etherase
MTSAPTPRNLRAELDTLTTEAFRPELAEIDQLPTLDIARLMNGEDASVPAAVASRLPEIAAAIDAVAERMARGGRLVYAGAGTAGRLGVLDASECPPTFNTDPTEVVGLIAGGPEAMVTSIEGAEDSKDLARTDLDALVLTPDDTVVGISASGRTPYAVGAVEHARRQGALTIGLSCNPGSALAAAAEHGIEVVVGPELLTGSTRLKAGTAQKLVLNMLSTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGATDPDIERALTEAGGEVKTAILILLADTDGPTATQLLTDSDGHLRAALKSAGE
>NZ_CP023689.1|WP_150501611.1|5374622_5375453_-|aldo/keto-reductase
MTASETFLIGGDLEVRRLGFGAMHLRPEPAQDRAAAVAVARRAVELGVTLIDTAHMYGWGANEDLLAEALHPYPDDLAIATKVGFRQTTTDQGWRYAGAPDELREQVDEALRRLRLDRIDLLQLHRLDPGVPLADQLGALRDLRDEGKIARIGLSEVDEGELAAARAVVDIASVQNRYNLLDREHEPVLKVCEEAGIAFLPWRPVAAGASGAQSEQIATIAKELDATPTQVAIAWLLAHSPVIVPIPGTSSIAHLEENLGAAAVHLGQDQYDRLTR
>NZ_CP023689.1|WP_150501621.1|5384268_5384943_+|maleylpyruvate-isomerase-family-mycothiol-dependent-enzyme
MTSADVHDVRDPGLPGRLLVVERDALVPLLRGRPAADFALPTVACPGWSVRDVLAHCSAALMRVVEGRFEEGVFSPECNDRDIAERAEWNDARVVDELERGMTEAGPVIAGAGGALDGVALGEWVHAGDVREVLGAPGAYAGDGLPDALRLLTWLTRERRLVPVHADVDDVDEPLRLGDPTAPRPPARYIGDAATLVRLYAGRAVEGAGFELVGVEAKELNIFG
>NZ_CP023689.1|WP_150501623.1|5385234_5385930_+|copper-homeostasis-protein-CutC
MSKRAVLEVIALGVEDAVAAQAGGADRLELVTDMAADGLTPPVETFAGIRAAVDIDLRVMLRLADGFAVGDVERVVRTARAMRDAGADEFVLGFLDADGGVDLEAVERVVGVLGGCRWTFHRAIDRAADRDALRKQLDGMPGLDTYLTAGSAEGVDDGLPTLLAEAVRGGEPGYEQRILVGGGLRLDHVPTLLDAGIDAFHIGGAARPEGWTGPVSATAVAEWRAVLDGGA
>NZ_CP023689.1|WP_150501625.1|5387191_5387590_+|ANTAR-domain-containing-protein
MTDNKDLLDKIAALQREVEQLRHALVSHAVVDQAIGVLRAVHGLDGQESWDVLQRVSQNTNVKLREVAEDVLRWAASGRLPDGIDPALREAVTAVGPTLRRPVLAPGHRGPRGTARPAPSGAEQWADGAATP
>NZ_CP023689.1|WP_150501627.1|5387669_5389718_-|AAA-family-ATPase
MSTPVDDPLDPLSRERSHLAGSRAALRAMREDVESLDISDVTANWVNAEVLARQIDDRIKALADLSDTPLFFGRLDYLHAPGAEQAEGAEGERFYIGRRHVHDAEGDPMVIDWRAPVSQPFYRASKKDPLDIGLRRRFGYTGGDLTAYEDEHLSDPAEAARTSKLLQQEIERPRVGPMRDIVATIQPEQDEIVRSGLGGTVCVQGGPGTGKTAVGLHRVAYLLYAHRERLARTGTLVIGPNKSFLHYIEQVLPALGELSVRQATVDDLVAHVEVRGADDATAAVVKGDARMAEVLRRAVYSHVTVPTEPVVVVRGSRRWRVPAYELEETVRELLDRGIRYGAAREALPQRIAHAVLVQMERSGEAPDDRVQDAVARNSAVKAAVKAIWPPVDPAKLVLRLLTDADFLAGHAAEILSEEEQKTILWAKPVRSVKSAKWSAADAVLIDEVNDLVSRTASLGHVVLDEAQDLSPMQYRAVGRRCTTGSATILGDLAQGTTPWATRSWDEALAHLGKSEGVIEELTAGFRVPTDVIAYASRLLPHIAPGLAPVASIRENPGFFEVREVSGTAEVVSACGELLRQEGSIGLIAADARIPALSEALAEAGLTYLAPGEETTRQTRLTLVPASLAKGLEYDYVLLDEPQAVVDGEPDERTGLRRLYVALTRAVSGLVVVHGAGLPVQLG
>NZ_CP023689.1|WP_107906281.1|5390011_5390191_+|hypothetical-protein
MSAATIHPAPAGARGATALQGSHRHRFGEALRAVRVFAGAAFDVIVLGEYGEEAGVRHK
>NZ_CP023689.1|WP_107906057.1|5390236_5391880_-|DEAD/DEAH-box-helicase
MNGPLIVQSDKTLLLEVDHEQADACRRAIAAFAELERAPEHIHTYRVTPLGLWNARAAGHDAEQVVDALVTYSRYPVPHALLVDIADTMDRYGRLTLSKHPTHGLVLTSTDRPVLEEVLRSKRIAPLVGPRIDPDTVAVHPSERGQIKQTLLKLGWPAEDLAGYVDGEAHPIELNEDGWALRPYQKQAVENFWHGGSGVVVLPCGAGKTLVGAGSMAQAKSTTLILVTNTVSARQWKHELMKRTSLTEEEIGEYSGTRKEIRPVTIATYQVLTTKRKGVYPHLELFDSRDWGLILYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTESERLAYATAEQEEKYRFCATTDTKRKVTEALVRRFAGQQILVIGQYIDQLDELGEHLNAPVIKGETSNAQREKLFGAFREGEISVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHKAHFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIVDADEILAEG
>NZ_CP023689.1|WP_150501629.1|5392030_5393251_+|TIGR00645-family-protein
MPNVQAIDREPSPPTTTLGFALFATRWLQAPLYFGLVAAQGVYVYKFFNELWALILRCVTGQATETYVMLAVLKLVDVVMIANLLIMVIVGGYETFVSRIGLQGHRDQPEWLSHVNSNVLKVKLATAIVGISSVHLLQMFVDVHRTSHHSLMWGTVIHMAFIASAAILAYMSGPMAAQAERAHQQTPHHEPVPEAPAAKVFVPAQSGPREDAPSAEERLRAAGFPARKLLEDFDSEHPRAFDRETVARLGKLDFVTAGRNVVFVGAPGTGKTHLAVGLGVRACQAGHSVLFASAAEWAARLAAARDAGRLARELTALDAHALLIVDEVGYTPFDPETAALFFQLVAHRYERASLIVTSDRPLARWDEVFGGPSALAMADRLAHHAELVRIEGESYRMRRATSAWAD
>NZ_CP023689.1|WP_150501630.1|5393228_5393444_-|hypothetical-protein
MRSERTARSRTALSVAVLSTAAALVTALAPAAAAAPSLPLPLPVAGGESLVTEGLTIEGPLINNVSLPTLR
>NZ_CP023689.1|WP_150501632.1|5393833_5396494_-|DNA-binding-protein
MSDPATPPRSLAEDLRVRDDASLTMLLRSRPDLITPVPTDLTQLATRAGTRASVVRALERLDRFALQTAEALAVATDPATYDELLALMAGDEGDPVVTGALPHALGTLREQALVWGADDRLRLVRTARELLTPSPQHPSPTGLGPTVQEATAGMSPGRIQEIVTTAGLPSTHDAVSAVSALTALFTDRTRMTALLAHAPEESREVLARLVWGPPYGQVTADPAARLRWLLDRGLLLPTAPGTVVLPREVALHLRSGRAHRATEPLPPPVEPASTHGPQVVDTTAAGQAYTALATVEELLKDWHEGGPAVLRAGGLSVRDLKRTAVALDVPEPVAAFWTELAYAAGLLASDGEADERFAATPAYDEWLEQPAAERWARLAESWLAATRTAGVVGGRDAKDRTLSALGPGLDRSAAPEVRHRVLTLLAGLPQGASPAPESVLARLRWERPLRGPQRDDDLRARLARWTLNEAELLGVTGRGALSAQGRALLGAPEAGPGGQPGGRGRSTGPSATGPTGATTDPTTATTHDATPAGPTPPAGASTGPGDKLPVHHEHPRPAGPSEPLSPVEQAVASAAAARLLAPLLPEPLDHVLLQADLTAVAPGPLRRPLADTLGVLADVESKGGATVYRFTPGSVRRALDAGRSASDLHAFLAEHSRTPVPQPLAYLIDDVARRHGHLRVGAASAYVRCDDDAVLNEILADKRAAGLRLRRLAPTVLAAQADPAGLLEGLRAMGFAPAAESAEGDVLITRADAHRTPPRSAPEPVPDGPPTPDATLLAAAVRAIRAGDLASTTPRKPSGAATAMTGGELPRTTPAETLATMQAAVLTGESLWIGYVNAEGSASQRVIAPVRVEGGFVTAYDHTADEVRTYPLHRITGVAELADDQI
>NZ_CP023689.1|WP_150501634.1|5396702_5398343_+|solute-binding-protein
MSEQAEQWIAILSLAFPVAAFLWEFAVVGRKRLGYRVQMDTLAADAADKPYADVLGDMRHDGHQLKDPSFVLLRIENAGSTKIVSEDYLADPADPYGIKVTFRDRRVAAVVLTDPSNNALRDFFFEEVTEGDSVRTVAKPGFRRNNNAVDRTGTIRLPKVTLPRGAEYKVLVVLERWPADTGTDPFPDPVVQGTDGQERWYDPLIRLLRLKATRTESHVFASRPAWWVIWILIAAVAVQANFTLFVREDKRPPLDCVKGTLYLHGSTAFAPAVRAAAQDYLARCDGADVHIPLADDTFKGSTDGVTDLDKAGKEAGIPVGEGLRDHLAFTDGLASDGHPRLIPRPVALSVFTLVVNKDAGVENLKLDQIRDVFAGRVKNWSDIGGNDVPVHLVNRDPGSGTRSTLVAKVLAGKEPPQFTETDCAALDPKRYGRCEVTSTDTMLNTTASTPGAVGYSEATAVAGHRAADGLVKVTIDGRQPTAEGVGATNYPYWQTEFAYTYGEAPAGSVAAAFLNFLTQQSGRDILRDHGHGLCSEVQNSGECRPA

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Crispr_ID: NZ_CP023689_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_10

5721160-5721261

Orphan

Consensus_repeat	Method
GTCGCGCAGTTCCCCGCGCCCCT	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP023689_10

>merge|NZ_CP023689|10|5721160-5721261|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCTAAAAGCAGGGAGTTGCAGTGGGCCTGCGCCTAGACGTGACCGTGGGCCTCGCAACCGTTGCGCAGTTCCCCGCGCCCCT

>NZ_CP023689|10|9|5721160-5721261|CRISPRCasFinder
GTCGCGCAGTTCCCCGCGCCCCT	AAAAGCAGGGAGTTGCAGTGGGCCTGCGCCTAGACGTGACCGTGGGCCTCGCAACC
GTTGCGCAGTTCCCCGCGCCCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_107905891.1\|5719100_5720099_+\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|235640
NZ_CP023689.1\|WP_150501956.1\|5721464_5722433_-\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP023689.1\|WP_125529118.1\|5717552_5718338_+\|dioxygenase	unknown	unknown	gnl\|CDD\|153375
NZ_CP023689.1\|WP_126901843.1\|5731141_5732170_-\|P1-family-peptidase	unknown	unknown	gnl\|CDD\|239070
NZ_CP023689.1\|WP_107905893.1\|5714246_5714891_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP023689.1\|WP_150501960.1\|5726273_5728373_+\|PTS-transporter-subunit-EIIA	unknown	unknown	gnl\|CDD\|182066
NZ_CP023689.1\|WP_150501966.1\|5732218_5733457_-\|low-temperature-requirement-protein-A	unknown	unknown	gnl\|CDD\|377704
NZ_CP023689.1\|WP_150501952.1\|5712673_5713954_-\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|274507
NZ_CP023689.1\|WP_107905886.1\|5728810_5729557_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150501958.1\|5725078_5726026_+\|1-phosphofructokinase	unknown	unknown	gnl\|CDD\|274804
NZ_CP023689.1\|WP_125529776.1\|5724277_5725039_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
NZ_CP023689.1\|WP_125529117.1\|5716879_5717431_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP023689.1\|WP_125529116.1\|5715041_5716586_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP023689.1\|WP_150506864.1\|5720548_5721130_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_CP023689.1\|WP_167537763.1\|5708132_5709785_-\|tyrosine-type-recombinase/integrase	unknown	unknown	gnl\|CDD\|271189
NZ_CP023689.1\|WP_150501954.1\|5718367_5718898_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
NZ_CP023689.1\|WP_150501950.1\|5710151_5710739_+\|NAD(P)H-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
NZ_CP023689.1\|WP_150501964.1\|5729746_5730961_-\|L,D-transpeptidase-family-protein	unknown	unknown	gnl\|CDD\|380079
NZ_CP023689.1\|WP_150506866.1\|5722576_5724100_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP023689.1\|WP_150501962.1\|5728492_5728747_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_107905891.1\|5719100_5720099_+\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	2.9025e-117
NZ_CP023689.1\|WP_150501956.1\|5721464_5722433_-\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.42267e-45
NZ_CP023689.1\|WP_125529118.1\|5717552_5718338_+\|dioxygenase	gnl\|CDD\|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	8.06536e-110
NZ_CP023689.1\|WP_126901843.1\|5731141_5732170_-\|P1-family-peptidase	gnl\|CDD\|239070	cd02252, nylC_like, nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-polymerized 6-aminohexanoate oligomers. Together with other nylon degradation enzymes, such as 6-aminohexanoate cyclic dimer hydrolase (EI) and 6-aminohexanoate dimer hydrolase (EII), EIII plays a role in the detoxification and biological removal of the synthetic by-products of nylon manufacture. EIII shows sequence similarity to L-aminopeptidase D-amidase/D-esterase (DmpA), an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. Like DmpA, EIII undergoes autocatalytic cleavage in front of a nucleophile to form a heterodimer. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	5.23403e-95
NZ_CP023689.1\|WP_107905893.1\|5714246_5714891_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.36624e-09
NZ_CP023689.1\|WP_150501960.1\|5726273_5728373_+\|PTS-transporter-subunit-EIIA	gnl\|CDD\|182066	PRK09765, PRK09765, PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional.	8.98358e-132
NZ_CP023689.1\|WP_150501966.1\|5732218_5733457_-\|low-temperature-requirement-protein-A	gnl\|CDD\|377704	pfam06772, LtrA, Bacterial low temperature requirement A protein (LtrA). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes.	1.31777e-93
NZ_CP023689.1\|WP_150501952.1\|5712673_5713954_-\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.39002e-51
NZ_CP023689.1\|WP_150501958.1\|5725078_5726026_+\|1-phosphofructokinase	gnl\|CDD\|274804	TIGR03828, pfkB, 1-phosphofructokinase. This enzyme acts in concert with the fructose-specific phosphotransferase system (PTS) which imports fructose as fructose-1-phosphate. The action of 1-phosphofructokinase results in beta-D-fructose-1,6-bisphosphate and is an entry point into glycolysis (GenProp0688).	8.81792e-127
NZ_CP023689.1\|WP_125529776.1\|5724277_5725039_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.13455e-81
NZ_CP023689.1\|WP_125529117.1\|5716879_5717431_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.80351e-16
NZ_CP023689.1\|WP_125529116.1\|5715041_5716586_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.03563e-66
NZ_CP023689.1\|WP_150506864.1\|5720548_5721130_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	3.53584e-10
NZ_CP023689.1\|WP_167537763.1\|5708132_5709785_-\|tyrosine-type-recombinase/integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.29231e-24
NZ_CP023689.1\|WP_150501954.1\|5718367_5718898_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	3.68329e-49
NZ_CP023689.1\|WP_150501950.1\|5710151_5710739_+\|NAD(P)H-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	1.7843e-40
NZ_CP023689.1\|WP_150501964.1\|5729746_5730961_-\|L,D-transpeptidase-family-protein	gnl\|CDD\|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	4.47587e-71
NZ_CP023689.1\|WP_150506866.1\|5722576_5724100_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.50018e-68

>NZ_CP023689.1|WP_150506864.1|5720548_5721130_+|TetR-family-transcriptional-regulator
MEIARAAAALFVRRGLRATRAEDIAQAAGIAPRTFYRYFATKEEAVSPLYAVGADRWTQAVRDAPAELPVPQALEHALRHTLTPGAGVSEASWEWARTLVRLAISNPALRKVWAEVCHESEAKLAEALAQRSGTDNVAAHNFAAAVAAASVRVAVETWATGDAPAEGPQGPAAQALRNLDALRNFPWEDITAV
>NZ_CP023689.1|WP_107905891.1|5719100_5720099_+|sigma-70-family-RNA-polymerase-sigma-factor
MATRAVARRQSATGGTADAARSVRAHGGEIADRDLVGMYLDEIARTPLLDAAKEVELSQIIEAGVFARQVLDGYEEAKADATRDELEALVADGERAKDIFIRSNLRLVVAVARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYRKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRVQREFNREHGRDPEHTEIAAELGSTPERVADVLDWARDPVSLNMSVDDEGETQFGDLLEDTSAVSPEQSVLTLLRSEELDDLIGRLDQRTASIIKMRYGIEDGRERTLTEVGKEHGLTRERIRQIEKHALLELKKLARSTGFDAAA
>NZ_CP023689.1|WP_150501954.1|5718367_5718898_-|GNAT-family-N-acetyltransferase
MPSGRTEVQVRPGIESDLDALVAIYNHYVRETPITFDTTVFTPEERRPWLLSHPEDGPYRLMVATEADSTGNSQRILGYATSGPHRPKPAYATSVEVTVYLAPDAGRRGIGTLLYEALFDALAGEDLHRAYAGIAQPNEASVRLHERFGFRHVGTFREVGRKFGRYWDVAWYEKDL
>NZ_CP023689.1|WP_125529118.1|5717552_5718338_+|dioxygenase
MSAAAQERMPALYLSHGAPPLADDPIWPGELAAWSAGLPRPKAILMVSAHWEEAPLAIGATERVPLVYDFWGFPEHYYQVTYPAPGAPELAASVRKLLRAPGTPVQDIPDRGLDHGAYVPLVEMYPEADIPVLQVSMPTLDPVELMEIGRKLAPLRDEGVLIVGSGFFTHNLAALRQGGIPAWSVEFDDWGRRALESRDWDALLDFLHKSPAGRYAHPRTEHFAPLFVTMGAADAAGEQAAQKSVIDGFWMGLAKRSVQFG
>NZ_CP023689.1|WP_125529117.1|5716879_5717431_-|MarR-family-transcriptional-regulator
MNTASTPAPPASATAPASSAPTQETRWLTDEQQRVWRTYLDAVTLLEDHLDRQLQRDAGMPHIYYGLLVKLAESPRRRLRMTELAMYAKITRSRLSHAIARLEKNGWVRREDCPDDKRGQFAVLTDAGVAVLKETAPGHVEAVRQAMFDRLTEEQQKALGEIMRIVAEGLQPTEAGADLPWLR
>NZ_CP023689.1|WP_125529116.1|5715041_5716586_+|MFS-transporter
MSETAAKAPGSGLGAAVDPNRWKALAFIAIAQLMVVLDATIVNIALPSAQQDLGISDGNRQWVVTAYALAFGGLLLFGGRIADLWGRKRAFVVGLGGFAAASALGGAATNEAMMFGARALQGAFGALLAPAALSLLAVMFTDAKERAKAFGIYGAIAGGGGAVGLILGGFLTEYLDWRWTFFVNIPFAIVAAAGAWYVIREPEGGRNRSALDIPGVILSTLGLVSLVYGFTRAESEGWSDSMTIGMFVASGVLLLAFVLVESRVKAPLLPLRVVTERNRGGIYLSLGLAIIAMFGLFLFLTYYLQIVKGYSPVKTGFAFLPMIAGMITGSTQIGTRLMTRVAPRLLMGPGFLVAALGMLLLTQLEIGSSYAALLLPAMLLLGLGMGTAFMPAMSLATQGVKPQDAGVASAMVNTSQQVGGAIGTALLNTIAASATTSYIADHIAGASSRSQQQLVQLEGMVEGYTSAIWFAVGILVAAAGIALTLVNAGRPGGSTVASSEEGAQDEVAVPVVAH
>NZ_CP023689.1|WP_107905893.1|5714246_5714891_+|TetR/AcrR-family-transcriptional-regulator
MQTVTPEARKAPRPRADALRNRERIVTAAREMFVEFGPDVPLDEIARRAGVGNATVYRNFPDRDALVREVVCSVINRTMAAAELALTQTGDAFEALERFVHTAADERISALCPMVQSAFDQNHPDLEASRERCERLVGAIMDRAKAAGQLRSDVDVGDVMIAAAQLSRPPAGTGCDIADRYVHRHLQLFLDGLRAPARSVLPGMALTMEDLRKA
>NZ_CP023689.1|WP_150501952.1|5712673_5713954_-|M6-family-metalloprotease-domain-containing-protein
MQPSRRIRPRRVAALVSVTALTFAVSTSAGTGHFTAGTSTVAGAGPISPEHPSALRPCMITGRPTIQMSEGVPTARGYSRSTGTVRALTVMVDFPDAPGPGRALDRFDEFFPQTQDWFRTSSYGRLDYRPETPISGWLQMPKSFRAYGIERGAPFDPGYRRLVQDIVVAADPKVDFREYDFLNVLVTPNAGPSALDTVLSVTFAGNTEAPVADGVSVANASFVYSRQDDGSGTYHRTGYRVLPHENGHVFGLPDLYTADGGAAVGHWDIMSEDWGANNDLLGWHKWKLGWLDGAQVRCAANPGTSEYALTPLAREGGPKLIFVPLSRRSGYALELRTREGNDESVCRPGVLIYKVDADVDTGMGPVKVEDSHEDSGGCTRSPNVHAELSDATYGPGEEFRDEERGVKVSVLGVDLAGSYRVRVERG
>NZ_CP023689.1|WP_150501950.1|5710151_5710739_+|NAD(P)H-dependent-oxidoreductase
MSVSPLKIGVLVGSVRPGRFADRVSRWFMSEIGRREDMETHVIDLSEPDLASELKLTLERSDGSGDAPTLAERIGGLDGFVVVTPEYNHGYPASLKLAIDYVYREWRAKPVGFVSYGGMAGGQRAVEQLRQVFAELHAVTLRDTVSFHMAWEQFDDDGHPHDQDGTAKAASVLLDQLAWWGLTLREGRAARPYDG
>NZ_CP023689.1|WP_167537763.1|5708132_5709785_-|tyrosine-type-recombinase/integrase
MANTKPKPVQRGRIRRNGSGYQASVYVGRDPLTKKKIYVYEQASSLPEAEKARTKLLHQVDEQRHPKREVTVAFLLDRWLGVAELDETSYERAEGIIRNYLKPTFGTLKAGKLTAEMLELFYSRLRQCQEQCEGRRNGKTEPMTKRKHVCEPLAANSIRKIHFILRPALNRGLRWGYVTTNVAALAEPPSQPKPNPDPPTPEEAALVLNTAWQRDLDWGTFLFMTMVTGSRRGEMCALRWSDINFDRLELFVKHSNNGRRIKDTKTHQRRRQAIDVITRNVLLAHRERAKERCKALGGELARDAFVFTSEADSSLPLKPPSVSQRYRRLAEKLKIHTHRLKDLRTYNVTELLGNGADVRTVAGRVGHRSNGATTLKYYAAFLATSDRQAVTAFAKQLPVPEGLLAEQPVTTVINGLRLVCQCGNESLWAMLVVTEGGAEALCGQCEAAVQARPDTAVGPIGRTIKVEAAPPHELAPWEVIAKDVADAIKDGTMLPGEDVPTVGDIAQAHGVSVSTAHRAFTQLKNDGLIEVSRGRRAIVLPRQEKNSDAE
>NZ_CP023689.1|WP_150501956.1|5721464_5722433_-|WYL-domain-containing-protein
MTTDTPARLLTLLSLLQTPREWPGGELADRLGVSRRTVRRDIDRLRDLGYPVQATLGADGGYRLVAGKAMPPLVLDDEEAVAIAVGLRAGAGHAVEGVEEASVRALAKLEQVLPSRLRHRVSTLQAATTPLTSGDGASIAPETLTVMASTVAGRERLRFAYRAKDGTESRRLTEPYRLVSTGRRWYLVAYDLDRGDWRTFRVDRVSEPFATGARFAPRELPTGNAAEYLRQSVWRRQEAYEFSVTFEAPVEFVAARVPGWLGVPEALDGGERCRLRGAVGDAVEWMAVRLAMVDCEFVVESPEELVRCVGELGGRMSRAAGA
>NZ_CP023689.1|WP_150506866.1|5722576_5724100_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MTQAAQAAQAAQAGDRRRWFALAIVMTAAFMDLVDVTIVNIAIPSIQREAGASFSQIQWITAGYALAFAAGLITGGRLGDIHGRKKLFLIGIGGFTLASALCGFAANPEMLVASRILQGAMAALMVPQVLSIVHATFPAHERGKVFGLFGAVVGLGAVTGPLLGALLTEWNLFGLEWRPIFLINLPVGIAGLILGSRFITESKAPKALKLDLVGVALVTIGLLMLLYPLTRGRELGWPVWGYVSMAGAFVVLAVLVLFERRKAARDGSPLVELSLFKVKSFAAGIAVQTVFGVALGIFFLVWTLYMQFGLGWSPLKAGLTGIPFSIAVSTAAGLSVQQLVPRFGRKVLQAGALVMGLGVLLYIWEANRYGLSIAPWQMALPLVVMGVGMGLIVAPLTDAILSEVPREHSGSASGLINTVQQMGNALGLGLVSVVFFGVVDDRLTEAKERTAAGLAFADGFQNALWWVAAVLGVIFLLMSALPKRPAQHVEGADDSAPATDKEPALAG
>NZ_CP023689.1|WP_125529776.1|5724277_5725039_+|DeoR/GlpR-transcriptional-regulator
MYAPERQQEILRLARDGGRVDVLSLAEEFQVTAETIRRDLKALDRAGLVRRVHGGAIPAGRLDFEPDLAEREGTAADEKDRIAKAALAELPAEGTMILDAGTTVARMAAALPLEASLTVVTHSLPIAARLADHPGMQLHLIGGRVRHRTRAAVDAWALRAYGEIRADVLFVAANGFSAEHGLTTPDLAEAAVKRAAVAAARRVVLLADSSKHGQEHFARFGDLGDVDLLITDSGLSPEDATAIERGGTEVLCV
>NZ_CP023689.1|WP_150501958.1|5725078_5726026_+|1-phosphofructokinase
MILTVTPNPSLDRTYEVPALDRGEVIRATGERMDPGGKGVNVSRAVAAAGRRTVAVLPLGGAPGALVADLLDAQGIEVAPVPVAGATRSNIALAESDGVLTKINAPGPELSAAEQELLLETVREQSRDADWIACCGSLPRGLAPSWYADVVARAHAGGARIALDTSGPALLEALRARPDVVKPNAEELAQAVGHPLTTVGDAVKAAEELRGMGAGAVLASLGADGQLLVDDEGAWFGSAPVGAVRSNVGAGDSSLAGFLIAGGSGPEALASAVAHGAAAVRLPGSVMPSPADLDLAAVTVTADVPVDRVLKEPVS
>NZ_CP023689.1|WP_150501960.1|5726273_5728373_+|PTS-transporter-subunit-EIIA
MSDMITPDLVDLDLSAGTKEAAARALAERMVAKGRVTDLEGFLADVAAREAQMPTGLDGGIGIPHCRSEHVTEPTLAFGRSAAGIDFGATDGPADLIFLIAAPAGADDAHLTILSALARQLMNSEFTDALRSVGDPASAAALIRGEEPPAAAAPSEDSVASSVAASADAATDTTAPVPGARTEGVNAPAPGAPAEAPADAERPFRIVAVTSCPTGIAHTYMAAESLENAGREAGVELVVETQGSAGFTRLDPAVIAAADGVIFAHDVAVREKDRFAGKPTVDVGVKAGINRPAALIAEVRAKAERGEATAAARPGTPVERAGEPGEGYGTKLRKWLMSGVSYMVPFVAAGGLLIALGFAIGGYQINEAKSVTEHFDWGQVDSWGALLFQIGAAAFGFLVPVLAGYIAYGMADRPGLVPGFVGGAISVTIGAGFLGGLVAGLIAGGVVLAIQRIDIPPVLRGIMPVVVIPLVSSAVVGFLMFVVIGKPISEAQKAMTDWLNGLSGTNAVLLGVLLGLMMCFDLGGPVNKVAYTFATAGISVAAPSDSAMKIMAAVMAAGMVPPLGMALATTIRKRLFTTAERENGKAAWVLGASFISEGAIPFAAADPLRVIPASMAGGAVTGALTMAFGSTLRAPHGGIWVTFLIGKPFLYLLAIAAGTAVTAGLVIVLKGMRGTAPDGTPAAESPAAATAEAKQPVAA
>NZ_CP023689.1|WP_150501962.1|5728492_5728747_+|hypothetical-protein
MPENVSVLQLLGPVVLALAAVLWVMGLVRLLRRNRPEVTPWQADPMLPGLPHQRQTAPALEAVELTPAERDAFAGLVRRLGDGH
>NZ_CP023689.1|WP_107905886.1|5728810_5729557_-|hypothetical-protein
MSVPYETAAYEPPESAESPEEHLARLLGRALNSFELPDEAIRRLDCALAHDSSLHSAHHSAGLHRETYRHTWLLADGSALTLWELVHNTARGREPQHEVYADEEELRAATARLPLPPDAPDFELPVTVQLSPIPTPRHAYVPDDSADHARRLLRRAENADRPGTETATLLTTAFAHQITQAFGRPCRAGRAGLCFSLYEHAFLLRDGEEVSLWEVEHTATPDGRHMCEVYVTEEAARDAMERRAAQVS
>NZ_CP023689.1|WP_150501964.1|5729746_5730961_-|L,D-transpeptidase-family-protein
MTTPDIAARRALGACAALMIGALTLTACGGSANADNDDKAGKDSKSSAATIEISAKDGSNGASINSTGVKVSDGKLTEVKMTVAESGQAVPGSLTADGGAWKPKEQLERGTKYRIAATAKDGDGRSTAADSTFTTVSSANSFIGTYTPDDGTTVGVGMPVSFNFDKAIGDKKAVQSHITVSSSSGQKVVGHWFGEQRLDFRPEEYWKAGSKVTMKIDLDGVEGANGVYGVQKKTVTFTIGHSQVSTVDVDTQTMTVVRDGKTLKSVPISAGSSEFTTYNGQMVITEKFEKLRMDSRTVGLANAYDIPDVPHAMRLTQSGTFIHGNYWYNKGNPPFGRQGTSHGCVGLQDVQGGQGDTPSKWFFENSTVGDVVIVKNSPDKTVTPDNGLNGWNMAWSEWVTGSAA
>NZ_CP023689.1|WP_126901843.1|5731141_5732170_-|P1-family-peptidase
MTVDALTDVAGLRVGHETRAGGGWLTGTTVVLAPEGGAVAAVDVRGGGPGTKETDALDPRNLVQKVEAIVLTGGSAYGLDAASGVMAWLEEQRRGVRVGADPAHVVPVVPAACVFDLGRGGDFRARPDAATGRAAVEAAAASEPGAPVRQGCVGAGTGATVGPVKGGIGTASTVLDSGITVAALVVANAAGSAVDPETGALYGELLQGRVRYPEEDVHRAARLRLTEIAAKNAPPPLNTTLAVVATDADLSKAQAQKLAGTAHDGIARAVRPVHLLNDGDTVFAMATGERPLDAGHPLALNEILAAGADAVTRAIVRALRAAESVDGPGGLWPSYGELYGEA
>NZ_CP023689.1|WP_150501966.1|5732218_5733457_-|low-temperature-requirement-protein-A
MTSSSTPAPDSPRPQGRRRPLRRLSARGRGETHRVATPLELFFDLCFVVAIAQAGIELVHSVAESHAGEGILNYAMVFFAIWWAWMNFTWFASAYDNDDVLYRVVTLLQIAGVLVLAAGISRAFEDHEYLAVLIGYVIMRLALVGQWLRVARSSSGPERRMALRYAGGVLLCQIGWVGLVVLPEDVRPWWFLAMAILEMCVPPFAEREHPTSWHPHHIAERYGLFTIIVLGETIAAATVAVKTGIDENDALGDLLPIAAGGLLIIFAAWWIYFVVPIHGHLRSNRQAFLWGYGHYVVFASAAAIGAGLEVAVEQTVGKAHISTLAASAAVTLPTALYLLTVWLLHSRYFKVGIAQQLVLPTAALLVICCTFLGDWGVLAAGIVSALTVVTGETLSARMTPKDRGTATRTPVA

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Crispr_ID: NZ_CP023689_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_11

5819625-5819751

Orphan

Consensus_repeat	Method
CGCCTCCGCCGGGTGCTCCGTCGTACGGCTATCCGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_11

>merge|NZ_CP023689|11|5819625-5819751|CRISPRCasFinder
CGCCTCCGCCGGGTGCTCCGTCGTACGGCTATCCGCAAGGTGCGGGCGGGCCGGGCAGTACGCCGCCTCCGTCGGCGGGTGCGACTCCGCCGCCTCCGCCGGGTGCTCCGTCGTACGGGTATCCGCA

>NZ_CP023689|11|10|5819625-5819751|CRISPRCasFinder
CGCCTCCGCCGGGTGCTCCGTCGTACGGCTATCCGCA	AGGTGCGGGCGGGCCGGGCAGTACGCCGCCTCCGTCGGCGGGTGCGACTCCGC
CGCCTCCGCCGGGTGCTCCGTCGTACGGGTATCCGCA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150502065.1\|5828888_5829728_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|238045
NZ_CP023689.1\|WP_107905821.1\|5817767_5818763_+\|cell-wall-assembly-protein-Knr4	unknown	unknown	gnl\|CDD\|379604
NZ_CP023689.1\|WP_150502044.1\|5809018_5809693_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|240289
NZ_CP023689.1\|WP_150502052.1\|5814823_5816158_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP023689.1\|WP_150502058.1\|5823053_5824664_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
NZ_CP023689.1\|WP_150502056.1\|5822141_5823029_+\|cellulose-binding-protein	unknown	unknown	gnl\|CDD\|349951
NZ_CP023689.1\|WP_150502048.1\|5811109_5811706_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_CP023689.1\|WP_150502046.1\|5809839_5810328_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150502050.1\|5812957_5814406_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184641
NZ_CP023689.1\|WP_150502060.1\|5824660_5825176_-\|DUF485-domain-containing-protein	unknown	unknown	gnl\|CDD\|377315
NZ_CP023689.1\|WP_150502061.1\|5825399_5827817_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_126901381.1\|5816934_5817459_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373065
NZ_CP023689.1\|WP_030952253.1\|5811901_5812882_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|179535
NZ_CP023689.1\|WP_150502073.1\|5831779_5833348_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_CP023689.1\|WP_125527996.1\|5827951_5828656_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150502069.1\|5830005_5830500_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
NZ_CP023689.1\|WP_150502071.1\|5830632_5831799_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|226651
NZ_CP023689.1\|WP_125527967.1\|5816270_5816765_-\|SUKH-3-domain-containing-protein	unknown	unknown	gnl\|CDD\|379608
NZ_CP023689.1\|WP_107905824.1\|5810393_5810996_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_CP023689.1\|WP_150502063.1\|5828707_5828917_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150502065.1\|5828888_5829728_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.54357e-11
NZ_CP023689.1\|WP_107905821.1\|5817767_5818763_+\|cell-wall-assembly-protein-Knr4	gnl\|CDD\|379604	pfam14414, WHH, A nuclease of the HNH/ENDO VII superfamily with conserved WHH. WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion and other three ones are involved in activation of water molecule for hydrolysis.	6.84989e-12
NZ_CP023689.1\|WP_150502044.1\|5809018_5809693_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|240289	PTZ00144, PTZ00144, dihydrolipoamide succinyltransferase; Provisional.	0.000729074
NZ_CP023689.1\|WP_150502052.1\|5814823_5816158_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.05104e-32
NZ_CP023689.1\|WP_150502058.1\|5823053_5824664_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	2.05328e-130
NZ_CP023689.1\|WP_150502056.1\|5822141_5823029_+\|cellulose-binding-protein	gnl\|CDD\|349951	cd06503, ATP-synt_Fo_b, F-type ATP synthase, membrane subunit b. Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.	0.00851312
NZ_CP023689.1\|WP_150502048.1\|5811109_5811706_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	1.75651e-68
NZ_CP023689.1\|WP_030952253.1\|5811901_5812882_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|179535	PRK03092, PRK03092, ribose-phosphate diphosphokinase.	0
NZ_CP023689.1\|WP_150502050.1\|5812957_5814406_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184641	PRK14352, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_CP023689.1\|WP_150502071.1\|5830632_5831799_+\|alpha/beta-hydrolase	gnl\|CDD\|226651	COG4188, COG4188, Predicted dienelactone hydrolase [General function prediction only].	4.82814e-10
NZ_CP023689.1\|WP_126901381.1\|5816934_5817459_-\|hypothetical-protein	gnl\|CDD\|373065	pfam14431, YwqJ-deaminase, YwqJ-like deaminase. A member of the nucleic acid/nucleotide deaminase superfamily prototyped by Bacillus YwqJ. Members of this family are present in a wide phyletic range of bacteria and a few basidiomycetes. Bacterial versions are predicted to function as toxins in bacterial polymorphic toxin systems.	8.02575e-11
NZ_CP023689.1\|WP_150502060.1\|5824660_5825176_-\|DUF485-domain-containing-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	5.35661e-21
NZ_CP023689.1\|WP_150502073.1\|5831779_5833348_-\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.28512e-59
NZ_CP023689.1\|WP_150502069.1\|5830005_5830500_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	4.30757e-17
NZ_CP023689.1\|WP_125527967.1\|5816270_5816765_-\|SUKH-3-domain-containing-protein	gnl\|CDD\|379608	pfam14433, SUKH-3, SUKH-3 immunity protein. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems.	1.06412e-64
NZ_CP023689.1\|WP_107905824.1\|5810393_5810996_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	3.85225e-92
NZ_CP023689.1\|WP_150502063.1\|5828707_5828917_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	2.73993e-20

>NZ_CP023689.1|WP_107905821.1|5817767_5818763_+|cell-wall-assembly-protein-Knr4
MTTGRLGQQAAPPNAAYAGQVVHFPDPVRASRHPRGVRVDDRGYPDFSPYARAAAEIAEPPEGFGVDELRLTDYVSANAALAATGHELWDTVPAVATPHGWTWHHAVGTRRLELVPVEVKALLRHHGGIATSAVDHDKRGTRPLQETRPAHFRLPKSGVAVTEAQALGVEEDLGYRLPGAYRSFLKAAGGCAPVGTALDAELGLLIDQPLFTVRDEAAVNDLVYVNKCLRDHLTKDYLGVGFVQGGLLAVKVKGDRIGSVWFCAFDDARDVDPTWPPAERVERLLMPCGEDFDAFLSRLAGSPPELETVANLMVDGGFARAVPVAAAAVGE
>NZ_CP023689.1|WP_126901381.1|5816934_5817459_-|hypothetical-protein
MMIMNATQTGPHAARSGDPRIGWSATETAHAPALHHRRDGILPTVAAALSVRGATLTGTAARGDQRPELHHLVQDFLDTLTSGERDRFTGRCAETILISRHIAAADATRSKRAARKPMTNGEARKALKQAKLTARRIREDGDPLHGSFASPCRACTALSAHFGVRIVDPAAADG
>NZ_CP023689.1|WP_125527967.1|5816270_5816765_-|SUKH-3-domain-containing-protein
MHTDRTSSTRFPVPVDAALRAAGWQPGRWDIKQAEVWADTLREHTSPAGHRHAVFPAAVEAWAEFGGLHIAPTGPGRQVAPAHLHFDPLHGLHMARTLGDLGRALDTEVCPLGAESDTEALLAIDAEGRIYALDHTGDWYLGPDIDQALAGLVAGIEPVRLTAG
>NZ_CP023689.1|WP_150502052.1|5814823_5816158_+|sensor-histidine-kinase
MTTTGEDRAGDPPPGAGLWWWDRMRSAVLDVSLAVVSALECGVEGVRFARDAGIPEAAGVVFGVLAGAVLVLRRRWPIAVVLVSIAVLPAQMGFLLGIVGLYTLAASELPRRIIASLAGMSFVGTLIVTFVWVRQGVARGELTFGDWVVPFASVTTALGVTAPPLLLGLYVGARRRLMESLRERADSLERELQLLAERAEERAEWARGEERTRIAREMHDVVAHRVSLMVVHAAALQAVARKDPEKAVKNAALVGDMGRQALTELREMLGVLRSGAATADRARGAVVPLAAVGAAAAAAADRELTGGDEGTAEGPCLSELEELIGQSAAAGMVVELSVEGETRGYAPKIEQTAYRVVQEALTNVHKHAAGAKTQVRLAHRMSEIAMQVENGPPPEPASASSARLPSGGNGLVGMKERVVALGGVFVSGPTDAGGFRVSAVIPAA
>NZ_CP023689.1|WP_150502050.1|5812957_5814406_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSAIRPAAVVVLAAGEGTRMKSATPKVLHELCGRSLVGHVLAAARELDPENLVVVVGHAREQVVAHLGEIDPGVRTAVQAEQNGTGHAVRMALEELGGGIDGTVVVVCGDTPLLTGETLTALAATHSGDGNAVTVLTAEVPDATGYGRIVRDGASGAVTAIVEHKDATESQRAIREINSGVFAFDGQLLADALGKVRTDNSQGEEYLTDVLGILREAGHRVGASVAADHREIAGINNRVQLSEARRILNDRLLTAAMLSGVTVIDPATTWVDVTVTFEQDVTVQPGTQLQGDTHLGEGADVGPNTRLKDTRVGAGARVDNTVSNGAVVGAHASVGPYAYLRPGTRLGAKGKIGTYVETKNASIGEGTKIPHLSYVGDATIGEQTNIGAASVFVNYDGKDKHHTTVGSHCRTGSDNMFVAPVTIGDGAYTAAGSVITKDVPPGSLAVARGQQRNIEGWVARKRPGSAAAKAAETASRQVEGED
>NZ_CP023689.1|WP_030952253.1|5811901_5812882_-|ribose-phosphate-diphosphokinase
MTGIKTTGEKKLMFFSGRAHPELAEEVAQQLEVGVVPTKAFDFANGEIYVRYQESARGADCFVIQSHTAPINQWIMEQLIMIDALKRASARSITVIVPFYGYARQDKKHRGREPISARLIADLMKTAGADRILTVDLHTDQIQGFFDGPVDHLFALPLLADYVGRKVDREKLTVVSPDAGRVRVADRWCDRLGAPLAIVHKRRDKDVANQVTVHEVVGEVKGRVCVLVDDMIDTGGTICAAADALFAHGAEDVIVTATHGVLSGPAADRLKNSRVGEFVFTNTLPTPGELSRDLDKLTVLSIAPTIASAVREVFEDGSVTSLFDEQ
>NZ_CP023689.1|WP_150502048.1|5811109_5811706_-|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MSEVKISAETRTEFGKGAARRIRRDSKVPGVLYGHGSDPLHLTLPGHDLLLALRTPNVLIALDIDGKTNELAIPKSVQRDPIKGFLEHVDLLLVKRGEKVTVEVPVHAEGELAPGGYLLEHVLNALPVEAEATHIPEAVTVSVEGLEAGASILAKDITLPKGTTLAVEEDAVVLQVLAAQAEEAPEGEETEGEEVAEA
>NZ_CP023689.1|WP_107905824.1|5810393_5810996_-|aminoacyl-tRNA-hydrolase
MDVTTDPSAPWLVAGLGNPGAEYAMNRHNVGFMVADLLAERIGGKFKRAGKAQAQVVEGRIGPPGPMNRRVILVKPMSFMNLSGGPLNALRDFYKVPLGNIVAVHDELDIDYGTLRLKLGGGDNGHNGLKSMTKVMGPDYHRVRFGIGRPPGRMQVADFVLKDFGSTERKELDYFVDRAADAVECLVIEGLERAQSTYNS
>NZ_CP023689.1|WP_150502046.1|5809839_5810328_-|hypothetical-protein
MPSAVVSSQGAVSALRFGRLAAMGTVAVLILIAGVWASWGTAHHVMLTKGRESGTISVKRCGQDTCSGPYTPVSAGSRARKSVVIEKNVAVRKGQTYTVVIKPGGDEVVRSGPAGVLYAWVPLGGALLLASVVVAGGLRRTRLAWVMAGSGTVLLTAAFAVI
>NZ_CP023689.1|WP_150502044.1|5809018_5809693_-|LPXTG-cell-wall-anchor-domain-containing-protein
MRTLNRVGALSAVAAAALLSAPAAAHATAPGDNGTVKIHDATTGEELPKNEPHVCEFYLDAFGFDSVQQVSWHIEAWAPTAAVKGETVKSGAITLDGEGHGRTDDMTLPDGHYKLFWNFQGEKGSAKHKVFWTDCEDEEPGGGTPTPSASEPGSETPGEETTEPAPSPSTSAGEAAPSSSPSAQGDAEGDLAETGNGAPVGLLSAAAAALLGAGGYLVFRRRRA
>NZ_CP023689.1|WP_150502056.1|5822141_5823029_+|cellulose-binding-protein
MSSEPCSLHDFVVVKGRGYRPEQVDAYVDALFRDRDAAWERAARLTVLAKEMEAEAERLREEVAQLGPQTYEALGDQARRLFELVQKEAEAVRESARQEAESLVGKAKEWASGLRDTARTHADALTAEADAYTEERMLAARAEADEIRVAARRMVREERGLELLALRELRHRTTRMLTEQSKDHDERWAVFAQEAEERKAAQKAAEADRQTRAEAALAEAKELRAEADATARTAQEEAQDLATELVAQARQQAEEIARETEQVLREHGEVWDDVRTHIGQMRNSLTALTGQAAQE
>NZ_CP023689.1|WP_150502058.1|5823053_5824664_-|cation-acetate-symporter
MNDFSGNAQAMSLVAFCVVVTITLLLCVMTGPDRDDLDEFYTGYSSLSPVRNGLAIGGDYISAATVLGTTGVVALCGYDGIVLALSTALSLMLLMFLLAEPLRNAGRFTMGDALARRMPGRGVRIAACGVTLAALLPLMLVQLAGTGQLLAFILGFSSDSLKTGCVIGLGVLMISYAAIGGMKGTALIQILKMVMLLGSGAVVAVLVLRKFDWDPGALFNAAAAQSGVGPAFLQSGLQFAGSPYPRIDMISSQLAVVLGGAVLPHITMRMYTAKSARQVRRSMSWAVSSVALFVLVITVVGFGATALIGREVIAGADPRGNTAYLLGSRAVFGAEVSTAESLLFTAVTTAIFLTVLASVAGMILACANSLAHDLFATRMRELSGHREMALARLAAVGVGIPAIVLATLVQHRSLQPLVTLSFTLGASAIAPALVYSLFWRRYTRAGLLWTLIGGTAVVLALMPWTNLVSGSPASAFPEADFNWFPFTTPGLVSVPAGFLFGWLGTVKSGRREAEEQRRQYEAVEGWILAGAVRRGN
>NZ_CP023689.1|WP_150502060.1|5824660_5825176_-|DUF485-domain-containing-protein
MSSPHNRHNQYDPYNSREPHDPYDRFRPPPPASASPPPSYATYPWQPPVPPEPPAPPRHLTSDHPPLGHHSDLRILRGAYRWQRRVATLTALGYFTLFLILSAFAPGFMTGTITDGLPAGLVLALLQLPVTWLAIALYEHTARNYVDPIADRIRKEAALDARREAERRAGR
>NZ_CP023689.1|WP_150502061.1|5825399_5827817_-|hypothetical-protein
MDFNRRTAMAAGLGAAATAAVGAGSASVRAAGPATITIPGESPTSTNIPVARDLRASGGRYLALLTAERPPSGKGWYATYRVRVPRSGVYALTAVAVAPVETPHTEAVGSYLQLSVDGGPFREVARSQPDWYGSPAAWGDLSEMNLGEVELREGDGAFSLRVVEPTVLDNRIVYVLSLDHLVLRPLPGGPALRTAAVPRHRAGEPARLRLTLNAPATRPHPVRYAVTDYHGQRVAAGRAAVPAGRRTTTVTLPADLPPGHYRIHADDDVTSTFARLPVRRAVTRTGAADNPFGVNVWASSLVPPSRLDEFAAALRDMGAGWVRDGQSWPAAEPAPGAYDTAHHDRVIRTLRAHGLAVLDVLSPAPEWAMTDASLPLPADLRHAYRYARCLALAAPEALQLSNEPDVDTTRSTGDAHAAFVKATALGIKDARAEPPLVVLPGIAQSGPFQDLMLANDVVRYADVWAFHGYPDPADQDDPEFPGAAEEQHALARRQGAGDTPLWMTECGAFLTTPSDLTPAQERVQARYLVRSMVEGLAAGNARQFWFAAPPLHDDGVWFGLLDRDFGPLPAYSAFATLTSLLGAARFVGPVPQLPTGVRGFRFDDGCGQQVSVLWAMARHTRVSAPGVAYDIMGRRIERSGPAVVASPDPVYVVSRGAAASARARGAADALRRPGPGSLSPAEHIVLSQRYAARNAAPGKDDGDAPPPHGYRLGRRTRMSLDVYNFGDRGRYVTVAAEPMGAGWSVRPVSVADTRVWVPAGGRVGVEFSVEAGRSVRRKVDRRLVFGAWLDGEGEVPGSVALVHLK
>NZ_CP023689.1|WP_125527996.1|5827951_5828656_-|hypothetical-protein
MVANIGIGLVTSLLGGVFVWLWDRTKRTREVNRRAAFFGVRPGQTCLIVLGNKYNAPGTAHYRDVRAVVELSLLAGELGCKVAVESGDFRGSNGDRTEFCVGGPSGGANIRTGGHLAAHLPGVTIHAYDATLPDSMAIEVGGEKFRCDRGTQEYALVAKFQPAESGSPVFLVSGQTSVGNIAAVHFLRREYANVAGRLSSLERFCLLIKVSDIGTYEFHRAELEREVSAAAFGQ
>NZ_CP023689.1|WP_150502063.1|5828707_5828917_-|DUF397-domain-containing-protein
MKRSESSIPDASIVTGWRRSSYSDESGGNCLEVTDAAGVHVPVRDSKTPTGPAIVFSASAWTEFVTALR
>NZ_CP023689.1|WP_150502065.1|5828888_5829728_-|helix-turn-helix-domain-containing-protein
MAIEDNPRSREQYGAELKRRRESAGLTQEQLSQRAVMSRTHIAHIEAGRRRPDPDDARRLDQVLEGGGFFENFLPTLDGKKVAEHFAEAAELERQAVAIKEYASTLVPGFLQTPEYARDVLSSGHPAKSDEKRDSLLATRLERARLLDDFDSPKVTLLLSEAVLRQAVGGAQVMCDQLRHILALSESRRIRVHVLPFAVGSHALLAGAVKLMWFEELPPVAYVEGLKSGRIWELQGTVRELEDVYDHALGDAMSHRKSLALLRSVAEDYEHEAQREQHP
>NZ_CP023689.1|WP_150502069.1|5830005_5830500_-|GNAT-family-N-acetyltransferase
MPTLERLRANHAEALLAFEHENREYFARTVPDRGDQYFTPAGFAARHQALLAEQDAGICHFHVVLDVEGRLVGRINLMDVEDGSAELGYRVGELASGKGVATAAVAEMCRMAATAYGLTSLVAVTTLDNAGSRTVLERNGFVTLGETTVGGRPGIRYRREHLGH
>NZ_CP023689.1|WP_150502071.1|5830632_5831799_+|alpha/beta-hydrolase
MNRSPNSLRLSALAASVVLVLGPALTLPAVAAEAAPVASVTSAASAQLPRPTGPHPVGRSTLHLVDRDRPDPWVPSAGPRQLMVSMYYPARPGTGGPTAPYMTTEEARHLIELRAPDVIVPPEVISGVRTWAHTDARPARGRFPLVVLSPGFTFPRATLTGLAEDLASRGYAVALVDHPYENAGTTLPDGRTLPCAICDDFSTIGGDAVAESRARDVSFVLDRLTGRHPAWRYARVIDARRIGMAGHSIGGNSAAATMAGDARVRAGVNMDGTFFSKVPEGGLDGRPFLMFGAEARQGDESWHRTWADLDGWKRWMTVAGTDHGSFTDVPLLADLVGIPDTAQVPYERSLALTRAYVAAFFDLHLKGAPQPLLDGPSPDNPEVSVRLP
>NZ_CP023689.1|WP_150502073.1|5831779_5833348_-|MFS-transporter
MGSSRPAIPDTAPRAATDKRAAVVAALMLAMALAALDATIVSTAVPQIVGDLGGFSVFSWLFSGYLLAVTVTLPVYGKLSDTFGRKPVLIAGAAVFLLGSLLCAAAWNMAALIAFRIVQGLGGGALQGTVQTLAADLYPLKERPKIQAKLSTVWALSAVAGPGLGGVLAAYADWRWIFLINLPIGAVALWLIVRHLHEPQRATAGTRARVDWAGALAVFACGGVLLTALVQGGVAWPWLSAPSLALFAAGLALVAVVVLVERRAAEPIIPGWVWRRRTIAAVNLALGALGLLMVAPTVFLPTYAQAVLGLAPVAAGFVLSVWTLSWPVSAALSQHVYRRIGFRNTAMLGIGTASLILLAFLFLPYPGAAWQPTLLMLLLGAALGLFQLPLIVGVQSTVGWSERGTATASVLFCRQTGQTVGAALFGAVANGVLASRLGGANDLDSVTRALDSGGTAPEATRRAIADAVHAVYLGASCAAALAFLVLLLLAPRRFPVLKEPGDEAPDQVAVDAVKGAVTEDGR

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Crispr_ID: NZ_CP023689_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_12

6068593-6068712

Orphan

Consensus_repeat	Method
TGCAGGCGAATCCCTGAACCGCTCGGGCAC	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP023689_12

>merge|NZ_CP023689|12|6068593-6068712|CRISPRCasFinder
TGCAGGCGAATCCCTGAACCGCTCGGGCACGCGGCCGTGGCGGGGGAGGGCTGGAGGCCGTGGCGGGAATCGAACCCGCGTAATTCGCTTTGCAGGCGAATCCCTGAACCACTCGGGCAC

>NZ_CP023689|12|11|6068593-6068712|CRISPRCasFinder
TGCAGGCGAATCCCTGAACCGCTCGGGCAC	GCGGCCGTGGCGGGGGAGGGCTGGAGGCCGTGGCGGGAATCGAACCCGCGTAATTCGCTT
TGCAGGCGAATCCCTGAACCACTCGGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150502268.1\|6061538_6063212_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|224991
NZ_CP023689.1\|WP_150502274.1\|6070478_6070679_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150502272.1\|6067121_6068363_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|164795
NZ_CP023689.1\|WP_107905680.1\|6063208_6065518_+\|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132240
NZ_CP023689.1\|WP_150502275.1\|6070675_6071050_+\|type-II-toxin-antitoxin-system-death-on-curing-family-toxin	unknown	unknown	gnl\|CDD\|226180
NZ_CP023689.1\|WP_150502260.1\|6055669_6056962_+\|extracellular-solute-binding-protein	unknown	unknown	gnl\|CDD\|270450
NZ_CP023689.1\|WP_030955484.1\|6073251_6073893_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NZ_CP023689.1\|WP_125525469.1\|6057944_6058787_+\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
NZ_CP023689.1\|WP_150502262.1\|6056958_6057939_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|224096
NZ_CP023689.1\|WP_107905673.1\|6075995_6076787_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226011
NZ_CP023689.1\|WP_107905674.1\|6071166_6072960_+\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|223989
NZ_CP023689.1\|WP_150502277.1\|6074027_6074801_+\|chorismate-synthase	unknown	unknown	gnl\|CDD\|225910
NZ_CP023689.1\|WP_030946851.1\|6055190_6055481_+\|DUF3039-domain-containing-protein	unknown	unknown	gnl\|CDD\|378609
NZ_CP023689.1\|WP_167537766.1\|6076783_6076972_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150502270.1\|6065819_6067034_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373067
NZ_CP023689.1\|WP_150502283.1\|6076986_6077571_-\|helix-turn-helix-domain-containing-protein	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|378968
NZ_CP023689.1\|WP_150502266.1\|6060648_6061542_+\|dehydrogenase	unknown	unknown	gnl\|CDD\|366378
NZ_CP023689.1\|WP_150502279.1\|6074797_6075907_+\|o-succinylbenzoate-synthase	unknown	unknown	gnl\|CDD\|239433
NZ_CP023689.1\|WP_107905677.1\|6068920_6070375_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
NZ_CP023689.1\|WP_150502264.1\|6058802_6060413_+\|family-20-glycosylhydrolase	unknown	unknown	gnl\|CDD\|119333

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150502268.1\|6061538_6063212_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	4.68134e-55
NZ_CP023689.1\|WP_150502272.1\|6067121_6068363_-\|hypothetical-protein	gnl\|CDD\|164795	PHA00370, III, attachment protein.	3.59974e-05
NZ_CP023689.1\|WP_107905680.1\|6063208_6065518_+\|molybdopterin-dependent-oxidoreductase	gnl\|CDD\|132240	TIGR03196, pucD, xanthine dehydrogenase D subunit. This gene has been characterized in B. subtilis as the molybdopterin binding-subunit of xanthine dehydrogenase (pucD), acting in conjunction with pucC, the FAD-binding subunit and pucE, the FeS-binding subunit. The more common XDH complex (GenProp0640) includes the xdhB gene which is related to pucD. It appears that most of the relatives of pucD outside of this narrow clade are involved in other processes as they are found in unrelated genomic contexts, contain the more common XDH complex and/or do not appear to process purines to allantoin.	1.0483e-178
NZ_CP023689.1\|WP_150502275.1\|6070675_6071050_+\|type-II-toxin-antitoxin-system-death-on-curing-family-toxin	gnl\|CDD\|226180	COG3654, Doc, Prophage maintenance system killer protein [General function prediction only].	1.92552e-20
NZ_CP023689.1\|WP_150502260.1\|6055669_6056962_+\|extracellular-solute-binding-protein	gnl\|CDD\|270450	cd14747, PBP2_MalE, Maltose-binding protein MalE; possesses type 2 periplasmic binding fold. This group includes the periplasmic maltose-binding component of an ABC transport system from the phytopathogen Xanthomonas citri and its related bacterial proteins. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.30177e-95
NZ_CP023689.1\|WP_030955484.1\|6073251_6073893_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	2.44987e-31
NZ_CP023689.1\|WP_125525469.1\|6057944_6058787_+\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	1.90137e-78
NZ_CP023689.1\|WP_150502262.1\|6056958_6057939_+\|ABC-transporter-permease-subunit	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.46899e-71
NZ_CP023689.1\|WP_107905673.1\|6075995_6076787_+\|hypothetical-protein	gnl\|CDD\|226011	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms].	2.40342e-30
NZ_CP023689.1\|WP_107905674.1\|6071166_6072960_+\|DEAD/DEAH-box-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	4.93586e-54
NZ_CP023689.1\|WP_150502277.1\|6074027_6074801_+\|chorismate-synthase	gnl\|CDD\|225910	COG3375, COG3375, Uncharacterized conserved protein [Function unknown].	1.82317e-36
NZ_CP023689.1\|WP_030946851.1\|6055190_6055481_+\|DUF3039-domain-containing-protein	gnl\|CDD\|378609	pfam11238, DUF3039, Protein of unknown function (DUF3039). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.23854e-36
NZ_CP023689.1\|WP_150502270.1\|6065819_6067034_+\|hypothetical-protein	gnl\|CDD\|373067	pfam14435, SUKH-4, SUKH-4 immunity protein. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems.	1.38657e-27
NZ_CP023689.1\|WP_150502283.1\|6076986_6077571_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378968	pfam12840, HTH_20, Helix-turn-helix domain. This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	1.51613e-11
NZ_CP023689.1\|WP_150502266.1\|6060648_6061542_+\|dehydrogenase	gnl\|CDD\|366378	pfam00941, FAD_binding_5, FAD binding domain in molybdopterin dehydrogenase.	1.341e-47
NZ_CP023689.1\|WP_150502279.1\|6074797_6075907_+\|o-succinylbenzoate-synthase	gnl\|CDD\|239433	cd03317, NAAAR, N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	6.80616e-175
NZ_CP023689.1\|WP_107905677.1\|6068920_6070375_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.14667e-26
NZ_CP023689.1\|WP_150502264.1\|6058802_6060413_+\|family-20-glycosylhydrolase	gnl\|CDD\|119333	cd06563, GH20_chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	0

>NZ_CP023689.1|WP_150502272.1|6067121_6068363_-|hypothetical-protein
MRQRIRPSHLRTSAAFVAAAAIAAAVPAVAAPSAYAEEAAPALVISNLPSTSPKPGDVYDENVVITNNGTAAADGVTFRVRLTRGLDFTEEAKGCSYSTVQDQVRQAVCELDLTVEPGASVETPVRFKALDSALMEAVEYGTSATGETPGEGYDDSYRRMTLTADSSADLVAVGEDTEALAGGQQSITVQLRNDGPGWIQNQESDDQPALMVKIPKDTVASEVPKECAPFGIDGPSAPGGTPGKSTYVCWPDDHTIDVGEAVSFTFMLDIDKDAKTTTGEVKATSVYDIHPEFDKNPANDKAPIRVAIPTDYEPGPATSGGSSDGGSTDGGATTGGDGNDPEGQSTGGTGSTGSTSAGTSTGGSSTGSVDGNLASTGSDGTPLIAGTAAAAAALGGGLILAVRRRRASAAKSS
>NZ_CP023689.1|WP_150502270.1|6065819_6067034_+|hypothetical-protein
MSTTTTTHVADTAIVLTEAELDPYVTHASTRRWLTGPGLPGDSGVLTFVELGRDGLRTVADSTGDPEDRLAAGLRDQLVIGGLLGPGGLETESVLLDGITGEISTTHFLHDRPDLMDRRPLAPSLRTLVRFAEATDELAGLRGQFASYVGRYGPKAVTEASRHLLAVFEEGTGGEPAPFWRMAALIRPLALVAGRAGVSGLALDLPARLLDEEFGRRQVVRFEDVDFPGTLTHEPTRRFLREVGLPEDAFLFSLDPDVSLPTLAEYYADVDPEAELPARADHLIRLGHLVDDNSLVVDGESGAVLNWSESEARLFPLNTDVSTLAFTLWLLHREQAMDAESGHALTSDAYDQLAMTMLQVLSTVDPTGTRAGRDGRHYWTEVFQDEASGVLESVGGPRQPARTA
>NZ_CP023689.1|WP_107905680.1|6063208_6065518_+|molybdopterin-dependent-oxidoreductase
MSNEAATATTAAEAAPAPEPIPHGLGASLQPADARAKTEGTFPYAADLWAEGLLWAAVLRSPHPHARIKSIDTAHAREMPGVRAVVTHEDVPGSPLLGRGKADRPVFASEVVRHHGEPIAAVAADHPDTARLAAAAVIVEYEVLDPVTDPEQAFEAEPLHPDGNLIRHIPLRHGDPDAAGDIVVEGLYRIGRQDPAPIGAEAGLAVPRPDGGVELYLASTDPHTDRDRAAACYGLEPERVKVVVTGVPGATADREDQGFQLPLGLLALKTGCPVKLTATREESFLGHTHRHPTLLRYRHHADAEGRLVKVEAQILLDAGAYADTSAEALAAAVGFACGPYVVPNAFIEGWAVRTNNPPSGHVRGEGAMQVCAAYEAQMDKLAKKLGVDPAELRLRNALATGDVLPTGQTVTCPAPVAELLQAVRDYPLPALPKDTPEDEWLLPGGPEGAGEPGAVRRGVGYGLGMVHMLGAEGADEVSTATVKVHDGVATVLCAAVETGQGFTTLARQIVQDTLGIDEVHVAPVDTDQPPAGAGCRGRHTWVSGGAVERAAKMVRTQLLQPLAHKFGMSTELLQITDGKITSYDGVLSTTVTEAMDGKELWATAQCRPHPTEPLNDAGQGDAFVGMSFCAIRAVVDVDIELGSVRVVELALAQDVGRVLNPAQLEARIEAGVTQGVGIALTENLRSARGLIRHPDLTGYSLPTALDAPDIRIVKLVEERDVVAPFGAKAVSAVPVVTSPAAIASAVRAATGRPVNRLPIRPQAAVVNAQ
>NZ_CP023689.1|WP_150502268.1|6061538_6063212_+|(2Fe-2S)-binding-protein
MTDDRHGEGTPQGAGRWDPLPQGEYDDGATAFVKLPEGGIEALLANPDSPLAAPGHGYVPPQITVAPGTGAGTDPAATGGWPTAGTPAEGDRWPDPNAPQEQGGDRFTYNPGATQQWNFSETAAGQDTGAPGQDVTGQWSIPVAGGDLPDESGEFTTSSLVEQWGGGTPPATLPGGAAAPWATQAPGRPWGQQAEAPAEALGTAPARPTDAEHAPGRPGPHAGDPHAAPAGGHPVRRPVGTGPASAAFDRDGDPSATPGAEPHARVEPGAFAPSRSERPADDSAESASEPSQATPGAGEPDSDDTDARGATEAPQGPAGPSADDESSTEAAEDSEQADDAPPLPGEEHPLASYVLRVNGADRPVSDAWIGESLLYVLRERLGLAGAKDGCSQGECGACNVQVDGRLVASCLVPAVTAAGSEVRTVEGLAVDGQPSDVQRALARCGAVQCGFCVPGMAMTVHDLLEGNPAPTELETRQALCGNLCRCSGYRGVVDAVKEVVAEREAHTGAGDGEQDGDEPRIPHQAGPGAGGVHPSAFEPRGGRGSHDQAYGQDGGQA
>NZ_CP023689.1|WP_150502266.1|6060648_6061542_+|dehydrogenase
MTTHAPQAAQAVTLPTTLDEAVAALAAMPAAVPVAGGTDLMAAVNSGQLRPAALVGLGRISEIRGWQYQDGHALLGAGLTHARMGRPDFAALIPALAAAARAAGPPQIRNAGTLGGNIASASPTGDALPVLAALEATLIVAGPGGARREIPVSHLLAGMEMLRAGELIGYVRVPLLHAPQVFLKATGRTGPGRAMASVAVVLDPARRGVRCAVGAIAPMPLRPLEAEQWVAQLIDWDNSRAIVPEALNAFGEYVAAACIPDPAPAEDGSMAQHPPAVLHLRRTVAALARRALGRALS
>NZ_CP023689.1|WP_150502264.1|6058802_6060413_+|family-20-glycosylhydrolase
MDLIPLPHRTERAEGFLELGDGFGIEAGPGTEGTARWLRTTLGAATGFALPPKKGDEYDVLHLSVRPGLDTEEYRLVVAPHGVHVQGGSPAGVFWGAQTMLQLLGPDAFRRAPLPGRTWRLPLTEIRDAPRFRWRGVMLDVARHFMPKDGVLRHLDLLAAHKLNVFHFHLTDDQGWRVEIRKYPRLTEVGSWRARTKFGHRASPLWEEKPHGGYYTRDDIREIVAYAAERHITVVPEIDVPGHSQAAIAAYPELGNTDVVDTTALSVWDTWGINPNVLAPTDNTLRFYEGVFEEVLELFPSEFIHVGGDECPKDQWRQSPTAQERIRELGLKDEDELQAWFIGHFDSWLTARGRRLIGWDEILEGGLAKGAAVSSWRGYAGGVAAARAGHDVVMCPEQQVYLDHRQDAGADEPVPIGFVRTLEDVYRFEPVPAELTPDEARHVLGTQANLWTEVMEDRARVDYQAFPRLAAFAEVAWSGLPAPAERDFADFERRLAAHYGRLDALGVAYRPPTGPRPWQRRPGVPGRPIDGPPPNR
>NZ_CP023689.1|WP_125525469.1|6057944_6058787_+|carbohydrate-ABC-transporter-permease
MNPARLVRRPWRLLAEASALLIAVVVAFPLYWMVLGAFKPAGEIESSEPRPWTLDPSLDSFRRVFEQNEFGRYFVNSLVVACTVVIASALIAFLAATAVTRFRFRFRTTLLIMFLVAQMVPVEALTIPLFFLMRDFGQLNTLGSLILPHIAFSLPFAIWMLRGFVKAVPEAIEEAAYIDGASRSRFLWQILFPLVFPGLVATSVFSFISAWNDFLFAKSFIISDTSQSTLPMALLVFYKPDEPDWGGVMAASTVMTIPVLIFFVLVQRRLVSGLGGAVKD
>NZ_CP023689.1|WP_150502262.1|6056958_6057939_+|ABC-transporter-permease-subunit
MTPVTPNSSGVLERRRVRVDRGFSRSSPRPQGRSRRRNQKTPWLYLAPALVVLGGLLVYPVYQLGLISFFEYTQAQVSGGEPTTFQGFGNYSELFSDPQFWQVLLATVVFAAACVVSTLAVGCALAVLLTRVRAVPRLALMLAALGAWATPAITGSTVWLFLFDPDFGPVNRLLGLGDHSWTYGRFSAFFLVLLEVVWCSFPFVMVTVYAGIRSVPAEVLEAAALDGASQWRIWRSVLAPMLRPILVVVTIQSVIWDFKVFTQIYVMTNGGGIAGQNLVLNVYAYQKAFASSQYSLGSAIGVVMLLILLAVTLVYLRLLRRQGEEL
>NZ_CP023689.1|WP_150502260.1|6055669_6056962_+|extracellular-solute-binding-protein
MKLAPRLAVLLTALAVTACAPQTSDNSSSDKDEKTGTLRVWLFQEVGNKPKEKVVDAVVADFEKEHEGAKVDVEYIPVETRAQRVKAAFNDPKSAPDVIEYGNTDTAGYVKDGGLLDVTKEFGDWSEAKDTDPTAEQSVTVDGKIYGAPFYVGVRALYYRTDIFEELGLEVPKTMAELATTARRIRAAEPELYGLVVGGAYTYGAMPFVWANGGELATGKGGSYASAIDSEAAQKGIKEYTSLFSDDNCPAAKCAGMGGNDTVTAFAAGKAGMAIGGDFSHAAVEAGKVKGKYAVVPLPGVKAGSVAPAFAGGNNIGVLKSTSHRTLAVRLMEQLASKETQASMFDAMGFLPTFGDVREKAAAEKPYVKPFVQTLSSGTKFVPASPAWSGIDSSLVLPTMFQEVISGKKDVAGAAGDAARKMDEAFGSAG
>NZ_CP023689.1|WP_030946851.1|6055190_6055481_+|DUF3039-domain-containing-protein
MSTLEPERGTGTGTLVEPTPQTSHGDGDHERFAHYVQKDKIMASALDGTPVVALCGKVWVPGRDPKKYPVCPMCKEIYESMGAGGGDDKGKGGDKK
>NZ_CP023689.1|WP_107905677.1|6068920_6070375_+|MFS-transporter
MTALEPRDADLAKTSDVPSVPESEESVLGRPYRALSIGIVSVVLLIAFEATAVGTAMPVAARELDGVSLYAFAFSGYFTTSLFGMVLAGQWSDRRGPLGALTAGIASFGAGLLLAGTAGVMWLFILGRAVQGLGGGLVIVALYVVVGRAYPERLRPAIMAAFAASWVVPSIVGPLASGAVTEHLGWRWVFVGIPVLVVFPLALALPQIRRLAGGPVDGSGRPASFDRRRIRLALGISVGAGLLQYAAQDLRWLSLVPGVAGAALLVPAVLGLLPRGTYRAARGLPSVVLLRGVAAGSFIAAESFVPLMLVTQRGLSPTLAGFSLAAGGGTWALGSWLQSRPRMEPYRERLMTLGMVLVAATIAAAPSVLIDSVPAWTLAVVWAFGCFGMGLVISSTSVLLLHLSAPEEAGTNSAALQISDGLSNVILLALGGAAFAALGGGSVTHTAMDASATTSHPAAFAAVFLPMAGVALVGAWVTTRLRER
>NZ_CP023689.1|WP_150502274.1|6070478_6070679_+|hypothetical-protein
MNELVLHLDPAARRELDDLADATGRLPEDIALDAVLDRLARESSAVRGTAQSLAGAHADLLRRLGE
>NZ_CP023689.1|WP_150502275.1|6070675_6071050_+|type-II-toxin-antitoxin-system-death-on-curing-family-toxin
MTRHLTVAEVTTIARIAFGGRPPEVRESGLFASAVHRPRARMFGTAAYEDLHEQAAALLHAIATNHPLVDGNKRTAWLAAATFLGVNGVGLEGCDQDTAYDLVIDVASGAESDIAVIAGRLRRL
>NZ_CP023689.1|WP_107905674.1|6071166_6072960_+|DEAD/DEAH-box-helicase
MTTTAASSSHHLSPAFPGRAPWGTASKLRAWQQGAMEKYIQEQPRDFLAVATPGAGKTTFALTLASWLLHHHVVQQVTVVAPTEHLKKQWAEAAARIGIKLDPEYSAGPLGKDYHGVAVTYAGVGVRPMLHRNRVEQRKTLVILDEIHHAGDSKSWGEACLEAFEPATRRLALTGTPFRSDTNPIPFVTYEEGNDGIRRSAADYTYGYGNALADHVVRPVIFLSYSGNMRWRTKAGDEIAARLGEPMTKDAVSQAWRTALDPRGEWMPSVLRAADQRLTEVRKGIPDAGALVIASDQDSARAYAKLIREITGSKATLVLSDDAGASKRIDDFSGSNDRWMVAVRMVSEGVDVPRLAVGVYATTISTPLFFAQAVGRFVRSRRRGETASVFLPTVPDLLTFANEMEVERDHALDKPKKEGEEDPYAESEKEMEEANKEQDEDTGEQEQFSFEALESEAVFDRVLYDGAEFGMQAHPGSEEEQDYLGIPGLLEPDQVQMLLQKRQARQIAHSRKKPDSEADLLELPAERRPVVSHKEMMELRKQLNTMVSAYVHQSGKPHGVIHTELRRVCGGPPSAEATAGQLRQRIAKVQEWATRMK
>NZ_CP023689.1|WP_030955484.1|6073251_6073893_+|helix-turn-helix-domain-containing-protein
MTAETSQTLDRGLRVLKLLADTDHGLTVTELSNKLGVNRTVVYRLLATLEQHALVRRDLGGRARVGLGVLRLGRQVHPLVREAALPALRSLAEDIGATAHLTLVDGTEALAVAVVEPTWTDYHVAYRAGFRHPLDRGAAGRAILSARQQPTDEPGYTLTHGELEAGASGAAAPLLGVTGVEGSVGVVMLADSVPERVGPRVVDAAKEVAEALR
>NZ_CP023689.1|WP_150502277.1|6074027_6074801_+|chorismate-synthase
MTSLSIRTVHDVAGFAAVADYFSDVWQTPRTAPPLLPETLHSIAHAGGAVHAAFEGERLTGACVAVFGPPLTREVYSVLAAAERGLGVPLKEAQRAWAVELGARTMRWTFDPLVGRNARFNFVKLGAEGTEYLVDFYGPMADGVNDGDETDRLAVTWDLIEPGRHEGVAGPAEREVAPTTHAAPDGGPLARRDLSDRHVWCRVPDDVVALRATDPQLALRWRRAVRDVFTKAFADGFLATGMSRDGWYTLTRREAAS
>NZ_CP023689.1|WP_150502279.1|6074797_6075907_+|o-succinylbenzoate-synthase
MKLERVEIVHVAIPLVSPFRTSFGTMTTKDTFLLHVVTDTAEGWSEFAADPEPGYCSEFVAGAEIVLRDFLLPRVAALPVVAAAHLGPATDGVKGHELAKAALETAVLDAELRSYGMSLATYLGAVRERVPAGVSVGIQQTIAELLDAVEGYLAEGYVRIKLKIEPGWDLEPVRAVRDRFGWDLPLQVDANTAYTLADAEHLRRLDDFGLLLIEEPLDENNLYAHARLQQRITTPVCLDESLHNARDTASAIAMDACRVVNVKPARVGGYLEARRVHDVAHAHGVPVWCGGMLETGIGRAPNLALAALPGFTLPGDTSASSRYFAEDITEPFVLVDGHLPVPRTPGIGVRPLPEALRRFTRERRDLYVT
>NZ_CP023689.1|WP_107905673.1|6075995_6076787_+|hypothetical-protein
MFSRLTRPRAVALCALPVVALLATAAFAPLPFSLTQPGLTADVLGENRGEQVITISGAPTRDTTGELRMTTIEATSPDTDVSLGDVVDAWFSTDKAVMPRDSVYPSGRSTREIEQFNTEQMRESQGDATEAALNYLDLNDKDVKVTLKLADVGGPSAGLLFSLGIIDKLDGDGTGGDLTGGRTIAGTGTIDPAGKVGAVGGVSLKTQAASRDGATVFLVPKAECGDAKAELPKGLRLVPVTTLKGAVNALTALQSGKGSVPSC
>NZ_CP023689.1|WP_167537766.1|6076783_6076972_-|hypothetical-protein
MQHPETRLALHHARAADLHAQAEAHRLAARIRQPHDIRSRLGWTLVEVGLRLATPRTTALAH
>NZ_CP023689.1|WP_150502283.1|6076986_6077571_-|helix-turn-helix-domain-containing-protein
MTESHPPKVHDLDARSLRGLAHPLRMQMLDALRFGGPATASQLAEKLGESSGATSYHLRQLAAHGFVEDDPERGKGRERWWKAAVQGLRFDDALLRDPNPDVRGAADLYLHEVATTQTRELSTWLGTRGEWSEAWNRSADMSSMTLRLTPELAEELAGRLHDLIDSYRDRPDVADALDASTIRVQTRTFPISTD

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Crispr_ID: NZ_CP023689_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_13

6188516-6188608

Orphan

Consensus_repeat	Method
GCCGGTCCGCATTCTTTTCAGCCCGTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_13

>merge|NZ_CP023689|13|6188516-6188608|CRISPRCasFinder
GCCGGTCCGCATTCTTTTCAGCCCGTCCGCGGGTCTTTCTCGTCCGTCCGGTGTGTGACGGCGGGCCGGTCCGCAGTCTTTTCAGCCCGTCCG

>NZ_CP023689|13|12|6188516-6188608|CRISPRCasFinder
GCCGGTCCGCATTCTTTTCAGCCCGTCCG	CGGGTCTTTCTCGTCCGTCCGGTGTGTGACGGCGG
GCCGGTCCGCAGTCTTTTCAGCCCGTCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150502386.1\|6184329_6185730_-\|amidase	unknown	unknown	gnl\|CDD\|180437
NZ_CP023689.1\|WP_150502384.1\|6183854_6184349_+\|DUF3830-family-protein	unknown	unknown	gnl\|CDD\|315562
NZ_CP023689.1\|WP_150502390.1\|6188768_6189857_+\|MsnO8-family-LLM-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274646
NZ_CP023689.1\|WP_150502392.1\|6189872_6191735_-\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|238923
NZ_CP023689.1\|WP_107905592.1\|6181538_6182189_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	unknown	unknown	gnl\|CDD\|132048
NZ_CP023689.1\|WP_150502394.1\|6196592_6198200_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107906228.1\|6186943_6187756_+\|decarboxylase	unknown	unknown	gnl\|CDD\|226004
NZ_CP023689.1\|WP_163016920.1\|6182901_6183807_-\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	unknown	unknown	gnl\|CDD\|270223
NZ_CP023689.1\|WP_163016950.1\|6180757_6181537_-\|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA	unknown	unknown	gnl\|CDD\|224051
NZ_CP023689.1\|WP_107905583.1\|6194593_6194959_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150502397.1\|6199274_6200273_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|379588
NZ_CP023689.1\|WP_107905594.1\|6179819_6180584_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|224332
NZ_CP023689.1\|WP_150502388.1\|6185753_6186737_-\|D-2-hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240625
NZ_CP023689.1\|WP_150502395.1\|6198190_6199324_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107905591.1\|6182185_6182905_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	unknown	unknown	gnl\|CDD\|223836
NZ_CP023689.1\|WP_150502399.1\|6200460_6201057_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
NZ_CP023689.1\|WP_107905584.1\|6193788_6194454_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_167537768.1\|6192044_6193478_+\|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl\|CDD\|274507
NZ_CP023689.1\|WP_107905587.1\|6187766_6188498_+\|decarboxylase	unknown	unknown	gnl\|CDD\|226004
NZ_CP023689.1\|WP_107905582.1\|6195261_6196596_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|224037

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150502386.1\|6184329_6185730_-\|amidase	gnl\|CDD\|180437	PRK06169, PRK06169, putative amidase; Provisional.	0
NZ_CP023689.1\|WP_150502384.1\|6183854_6184349_+\|DUF3830-family-protein	gnl\|CDD\|315562	pfam12903, DUF3830, Protein of unknown function (DUF3830). This is a family of bacterial and archaeal proteins, the structure for one of whose members has been characterized. Structure 3kop probably adopts a new hexameric form compared to previous structures. The putative active is near the domain interface. 3kop is most closely related, structurally to Structure 1zx8, where the potential active site is located near residues E51 and Y53 (conserved in 1zx8). Beyond the two residues above, the other residues are not conserved. Also the shape of the active site differs from that of 1zx8. Structure 1zx8 belongs to family DUF369. pfam04126, which is part of the cyclophilin-like clan.	1.98122e-81
NZ_CP023689.1\|WP_150502390.1\|6188768_6189857_+\|MsnO8-family-LLM-class-oxidoreductase	gnl\|CDD\|274646	TIGR03558, oxido_grp_1, luciferase family oxidoreductase, group 1. The Pfam domain family pfam00296 is named for luciferase-like monooxygenases, but the family also contains several coenzyme F420-dependent enzymes. This protein family represents a well-resolved clade within family pfam00296 and shows no restriction to coenzyme F420-positive species, unlike some other clades within pfam00296. [Unknown function, Enzymes of unknown specificity].	1.62611e-176
NZ_CP023689.1\|WP_150502392.1\|6189872_6191735_-\|EAL-domain-containing-protein	gnl\|CDD\|238923	cd01948, EAL, EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.	7.08321e-104
NZ_CP023689.1\|WP_107905592.1\|6181538_6182189_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD	gnl\|CDD\|132048	TIGR03003, ectoine_ehuD, ectoine/hydroxyectoine ABC transporter, permease protein EhuD. Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.	2.31153e-80
NZ_CP023689.1\|WP_107906228.1\|6186943_6187756_+\|decarboxylase	gnl\|CDD\|226004	COG3473, COG3473, Maleate cis-trans isomerase [Secondary metabolites biosynthesis, transport, and catabolism].	7.39267e-47
NZ_CP023689.1\|WP_163016920.1\|6182901_6183807_-\|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB	gnl\|CDD\|270223	cd01002, PBP2_Ehub_like, Substrate binding domain of ectoine/hydroxyectoine specific ABC transport system; the type 2 periplasmic binding protein fold. This family represents the periplasmic substrate-binding component of ABC transport systems that involved in uptake of osmoprotectants (also termed compatible solutes) such as ectoine and hydroxyectoine. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.91733e-111
NZ_CP023689.1\|WP_163016950.1\|6180757_6181537_-\|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.02058e-137
NZ_CP023689.1\|WP_150502397.1\|6199274_6200273_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	1.03654e-61
NZ_CP023689.1\|WP_107905594.1\|6179819_6180584_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.6096e-24
NZ_CP023689.1\|WP_150502388.1\|6185753_6186737_-\|D-2-hydroxyacid-dehydrogenase	gnl\|CDD\|240625	cd05300, 2-Hacid_dh_1, Putative D-isomer specific 2-hydroxyacid dehydrogenase. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomains but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric. Formate dehydrogenase (FDH) catalyzes the NAD+-dependent oxidation of formate ion to carbon dioxide with the concomitant reduction of NAD+ to NADH. FDHs of this family contain no metal ions or prosthetic groups. Catalysis occurs though direct transfer of the hydride ion to NAD+ without the stages of acid-base catalysis typically found in related dehydrogenases. FDHs are found in all methylotrophic microorganisms in energy production and in the stress responses of plants.	3.97591e-123
NZ_CP023689.1\|WP_107905591.1\|6182185_6182905_-\|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.02655e-63
NZ_CP023689.1\|WP_150502399.1\|6200460_6201057_+\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.82925e-55
NZ_CP023689.1\|WP_167537768.1\|6192044_6193478_+\|M6-family-metalloprotease-domain-containing-protein	gnl\|CDD\|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	3.88573e-48
NZ_CP023689.1\|WP_107905587.1\|6187766_6188498_+\|decarboxylase	gnl\|CDD\|226004	COG3473, COG3473, Maleate cis-trans isomerase [Secondary metabolites biosynthesis, transport, and catabolism].	2.74033e-30
NZ_CP023689.1\|WP_107905582.1\|6195261_6196596_-\|ATP-binding-protein	gnl\|CDD\|224037	COG1112, COG1112, Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair].	1.36596e-12

>NZ_CP023689.1|WP_107905587.1|6187766_6188498_+|decarboxylase
MTALGFLYPGHSAEDDYPRIEQLLASDIRIDLVHTDIGEDAHRVDALLRMGSAERLAAGVEALRLTGAEAVVWACTSGSFVYGWKGAHEQVRGLAVAAGMPASSTSFAFAHAVQELGVRRVAIGATYPDDVAALFARFLTDAGAEVTAVRGSGIITAAEVGTWGEAEVFALAKEADTADAEAVLLPDTALHTAAHIQALENELGKPVLTANQVTVWEALRLTDRRVNAPALGELFTREPIVQV
>NZ_CP023689.1|WP_107906228.1|6186943_6187756_+|decarboxylase
MDISFLGGPRPQRGVGVVAPFDFALDRELWRWVPDEVSLHLTRTPYVPVEVSLDLARLVSEHETLSDGVHTLTAIAPEVVAYACTSGSFVGGIAGERAMCEAMTRAGAVPSVTTSGALLEALTELGVRRVALVTPYTVSVTRALEQYVAEAGVAVTGCAFMGLTRHIWKVPYRDVAGMARRAVGRRRVDALFISCTNLPTYDVIPQLEAELRIPVLSANQVTMWAALRRLGTRAVGPYQALIDPAARIDPATPSGPVLPDVPDVPEQEQQ
>NZ_CP023689.1|WP_150502388.1|6185753_6186737_-|D-2-hydroxyacid-dehydrogenase
MTSPAPGPSPASGAPPTLLVLDAEPLPRLGRLTGRARVEHADESTLAQRLPHADVLLVWDFTSHAVRHAWPGEGPRPRWVHTASAGVDHLMCQELTDSDTVVTNARGIFDQPIAEYVAALVLAMAKDLPRTLDFQRARQWRHREGQRVAGTRACVVGSGPIGRTIARTLKALDVTTALVGRVPRTGIHGPDDLDRLMSRADWVIAAAPLTEQTHGMFDLRRFGVMQPSARFINVGRGQLVVEEALAEALDKRWIAGAALDVFEDEPLTPDSPLWQLPGLIVSPHMSGDTIGWRDELGRQFVELYERWEAGRPLLNVVDKQRGYVPGR
>NZ_CP023689.1|WP_150502386.1|6184329_6185730_-|amidase
MTDLTALTAVQLLDGYRKGDFSPLDATRATLERAERIQPEVNAFVRLTADEALARAGESAERWRRGEPAGLLDGVPVTVKDILLLRGSPTLRGSKTVVDKGHWPEDAPSVARLRAHGAVFLGKTTTPEFGWKGVTDSPLSGVTRNPVDPSRTAGGSSGGAAAAVALGAGPLALGTDGGGSVRIPAAFCGIFALKPTYGRVPLYPASAFGTLAHVGPMTRDAADAALLLDVIGAPDSRDWSALPPAPGSFAAALSGGVRGLRVAYSPSLGGQVAVRPAVAAAVRRAVERLAGLGAWVEETDPDFTDPVDAFHALWFTGAARVTQHLGPHQRELLDPGLREICGVGARMSALDYLAAVDVRMELGRRMGRFHDSYDLLLTPTLPITAFEAGAEVPKGSGHRRWTGWTPFTYPFNLTQQPAATVPVGTDGDGLPIGLQIVAARHRDELVLRAAHALYEAGIARLTPCGS
>NZ_CP023689.1|WP_150502384.1|6183854_6184349_+|DUF3830-family-protein
MTDRFIEVSLVKREIHCTAKLLDDRAPLTCAAVWDALPLTGDVYHAKYARNEIYALFPPFAETEPPLENPTVTPIPGDLCYFAFAGTELGTKSYGYDREVRAGTTVVDLALFYERNNLLLNGDVGWVPGIVWGQVVEGLDEMAQGCNDLWRSGALGESLSFRRV
>NZ_CP023689.1|WP_163016920.1|6182901_6183807_-|ectoine/hydroxyectoine-ABC-transporter-substrate-binding-protein-EhuB
MAPPNGNDRDTPGTTRRSLLAGVAALGALGAAGCSRVATASTEDGGDLLDRLRAAGVVRLGIAGEIPFGYIDKNGDLTGEAPELAKVIFKRLGVDKVQPVPTEFGSLIPGLNSQQFDVVAAGMYVNPERCEQVIFSDPDYQMLDSFIVRKGNPKGLHDYKDVVEKKARFATGTGYAEIQYAVEAGYEEGDILIVPDQVAGLNAVEAGRVDVFAGTALTTREVVKKSAKAESTKAFAPLVEGEPHVDGGAFAFRPTETKLRDAFNVELAKLKKSGELLRILKPFGFTENEMTDLTAKELCGG
>NZ_CP023689.1|WP_107905591.1|6182185_6182905_-|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuC
MTSGLWELVLKGIWTTVQLLVLSALLAAAVSFVVGVARTHRLWVVRFLAGFYTEVFRGTSALVMIFWVFFVLPPAFGWQLVPLWAGTLALGLTYGAYGSEIVRGALGAVDPAQKEGGIALSFTPWQRMRLVLLPQAVPEMIPPFSNLLIELLKGTALVSIMGMGDLAFSGNLVRLALQESAEIYTYILLIYFVIAFLLTRVMRGLEKKLKAGVGKAPASGVTADEFKRAQTTGVGGAVS
>NZ_CP023689.1|WP_107905592.1|6181538_6182189_-|ectoine/hydroxyectoine-ABC-transporter-permease-subunit-EhuD
MKWDWNAVSDFMPYFWDGLLVTLQALVLGSLISFALGLVWALLMRTPTRWVRWPVGVVTEFIRNTPLLVQLFFLFYVLPEWGLTFSALTTGVFAIGLHYSTYTMQVYRAGIEAVPVGQWEAATALNLPMTRTWRMVILPQAIRRVVPALGNYVISMLKDTPLLMAITVLDMLGRARLFSQENFQFTEPLTVIGVAFILISYLASLLLRALERRLVH
>NZ_CP023689.1|WP_163016950.1|6180757_6181537_-|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA
MQHNPEKNPAENRSNGELIRLEQVTKRFGDNTVLDNLDFSVQAGKHVTLIGPSGSGKTTILRLLMTLTKPDEGRITVDGQQLFPAPEKQIREVRKKIGMVFQQFNLFPNMTVLRNITEAPVTVLGMSKDEAEARARELLDMVGLADKCDARPTQLSGGQQQRVAIARALAMRPQVLLLDEVTSALDPELVAGVLDLLRDIARTTDITMLCVTHEMNFARDISDQVLMFDSGRVIESGTPEKIFNDPENDRTREFLSAVL
>NZ_CP023689.1|WP_107905594.1|6179819_6180584_-|helix-turn-helix-domain-containing-protein
MALQHESTTPYHSVQDALRVLETVARHSTGVTEAELARHTGIGPERLTGLLRMLRREGYVEQIADGAYVTGDALARLGSAQGREQALRDNLQHTLDRLRDSVGAAVYISRYIDGEVKIDQFAAGPATPVVNEWVDFRFSAHATAIGKSLLGQLDHNGRRDHLSRHKMARLTSRTITNDRVLLSRLESQPPTVPHLDLQEYAVGTVCAAVPITAGSSVGCLALSLPVEHAHRLRQAADALNRSAAPVLLSLAIQS
>NZ_CP023689.1|WP_150502390.1|6188768_6189857_+|MsnO8-family-LLM-class-oxidoreductase
MTADETRGEAQGTAPVPLSVLDLVTVSAGHTATDALRTSVDLARLAESRGFHRFWVAEHHSMPGVASSSPAVILAHLAAHTNRIRLGSGGVMLPNHAPLVIAEQFGTLEALAPGRIDLGLGRAPGTDGATAAALRRTDHLNEGADDFPEQLAELTRFLDDDFPDGHPYRRIHAVPGPVQATSPGGVQSPHRPPVWLLGSSGFSARLAAVLGLPFAFAHHFSARNTIPALDLYRESFRPSAVLDRPYALIGVSALATDEEKEARRQVRAAALGMVRLRTGRPGLIPSPEEAEAYEFSPMEREFVETWNANVVHGTPDEVRAGLDDLQKRTGADELMITSNAPGMDVRLRSYELIADAYGLPAA
>NZ_CP023689.1|WP_150502392.1|6189872_6191735_-|EAL-domain-containing-protein
MRPIRRSSALRERAVSGTSEGPTPAADLIGPAVTESNALPSPGTGGPPYWSAFSAAPLAMAVVDRDGMVAGANSTFAELLGRPAQELTGTAAADLVDLASDTRTWHTYREVLRGRQAELLCTRRLKHPEGHFLWARVTVAPLPGDESGGVLLSVTDISAHRELQARVRHLQMHDPVTRLPNRTLFFERLTAALEVESYDESGTTGRIGLCYLDLDGFKAINDTLGNRVGDKLLAAVAERLTHCAEQAGYARSSPPLVARLGGDEFALLVEDSTGTEQLADLAESLLETLREPFDLSGRRLSVSASIGVVERHAAGTTPTALMQAADTTLYWAKADGKDRWTLFDPERNAHLITRQALAATLRAAIDRGEFALEYQPLVGMEDGRLRGVEALVRWNHPQFGVLAPNRFIGLAEEDGSIVPLGRWVLATACRQARAWQMAHPDEPPIFVSVNVAVRQVWDSDLVSDVARILEETELAPHLLQLELTESAVMGSSGRPLQDLQALSDMGVRIAIDDFGTGYSNLAYLSRLPVSVLKLDGSFVRGFQYESENSAAVPPNPADEVVVEAMIQLAHRLGLTVTAECVETMAQASRLRRIGCDTGQGWLYSRPVSPDRISELMGARV
>NZ_CP023689.1|WP_167537768.1|6192044_6193478_+|M6-family-metalloprotease-domain-containing-protein
MSREPHPEVHVPRQNPLLRGMGLLRDRPRLRSAAAVFTTMSALAATSLVVGPSVAEPFDAAPCALQRTDAHHSEGLDTWNAAYPRPARKLDAVMVFLSFPDAAPLTTPAELTADHFPATTRFFERASYGRFTLRPHPLRHWLRMPRPSTAYAIQRDWRVADRAAYLRDALAVADRQVDFSRYDLVYFVADPDAPGVDSDATKVVNLETPLRADGTDIRRVVTVFENHPPDRLVLAHETGHVFDLPDLYHRPVDGKGDWDTYVGDWDLMGSQFGMSPDLFGWHKWKLGWLEPRQVVCVQGGGAGAVRLTLEPLSAGPGAPPRTGAAGADSVFGTDGSSDPSGSSYVPSNSSYGTVPGFGLGHGTKLAVVRTGAESALAFEVRGPVGNDVETCRQGVLVYRVRSRTESGSGPVQVIDAHPHSEACWEESVYPPLADAPVALGESFTVPGEGVRVEVESRTASGAWTVKITTAGGARAVG
>NZ_CP023689.1|WP_107905584.1|6193788_6194454_-|hypothetical-protein
MSSTRDDLFSDAGFHATGVDAAARITPEGVAWLASAGTYPRSTLALWEERPSAPVVLPCGSVFDIVSAPALFGRRMLDRLWDGGPGSGPVAVYRGRILMFAAPGTAQRLPSLLRWEEFGRTDGMPPLLCHGTGDAVTVPAPADPEGPDMPLPDLDVPDVDLPLLAPSGSRWLVAPDTRNPWLPGPEVLLWAAVRAARAAVRISIFPHPDQGAKVYDVSRRR
>NZ_CP023689.1|WP_107905583.1|6194593_6194959_-|hypothetical-protein
MAEPTPRRNEPRLRPAPLLFEPTQVAADPEHFFDLESMDDPRALLARATELTQAFRAATDRAVEFQAIAAAQLADPRRFDRLTPADIAERAEWTEDYAKKMVEFGRDLMRGVEGAGHVDPV
>NZ_CP023689.1|WP_107905582.1|6195261_6196596_-|ATP-binding-protein
MTAVFDPGAAASAATDAILHNTLHSEARGVVVDSPPGAGKSTLVVRAALELADAGRPLMVVAQTNAQVDDLVLRLAEKDPELPVGRLHSSDSDPYDKALDDLPNVRKSAKAADLAGLAVVLSTAAKWAHVKVEEPWRHAIVDEAYQMRSDSLLAVAGLFERALFVGDPGQLDPFAIVGSEQWAGLSYDPSASAVTTLLAHNPDLPQHRLPVSWRLPASAAPLVSDAFYPYTPFRSGTGHDDRRLTFAVPSDGSGPDRVIDEAAESGWGLLELPARHTPRTDPEAVRAVATVVRRLLDRGGAATSERSPDAAPLTADRIAVGTAHRDQAAGVRAALAELGVTDVTVDTANRLQGREYDVTVVLHPLSGRPDATAFHLETGRLCVLASRHRHACIVVCRAGVSDLLDDYPSTEPVQLGTLVKFPDGWEANHAVLARLAEHRVVWRP
>NZ_CP023689.1|WP_150502394.1|6196592_6198200_-|hypothetical-protein
MSLISTLARLEAVSTGRAQPAATVRHRHLSQRPLVFVPLTTAGEAGAPLGALVGTDRDAPHLLVVPQPRDRDLRFAFLSELADVVLPYIDSFAEDVEAAERNETDPETGKRVKVEVELCADAPQLIMPSRAGADFVRLLGRSMRFRRTAEQDPEAPYPAPPRVPLLGRWLTHFGERARVPGSSLLPAMTDLLSRHWATGQSTLEDQHLGALLAWIDPPEGETGAEAALRAELARDRDGQLLCPPAGPATDPAFDNKLLAPAIERYDRARTALAASEDGLEADDRLGHLTAAEREIRALVASRTRPTWDAVWRGLDLLRELPVAGRVEERWTRDRWSFTGHRDRVVAGEPPQPRRDDAVTAANKLAAREREQARLEAQEALDDPLVMAGRRLAGEAFAGEVTDVVMAYSEGKRPSPRPLVTVRTDDRPHLGERVKVFRSLGGKPQSAEFVGHEEALDEDGGALLVLRVLDKMGRGKEPEEGSVPQKGDLVCFTLFEHEQRGGAKLPEPEQTPWTHGGPPGEQESEAADPLTQEDVL
>NZ_CP023689.1|WP_150502395.1|6198190_6199324_-|hypothetical-protein
MPLPRTRGTALRHRLAELRGPDVPAKALDARALAALAANPGCKRRAILDGAGVNKAALAGALGSPSAFGQSQFALTRGNAFEAKVKADGGAELLRLVREKLDRGAEPPAHARVPELTATGPEGRTARTALALREATEARGEWTLLDHPMLALDVAGSPAFLEPDAVVVHPDGSWTVVEIKSFPMLDGSADPAKVGAAARQAAVYVLALEQVAARLESVPRVRERVLLVCPKDFSNLPTASAVDVRKQRAVTARQLDRLTRIEDIADALPAGTCFSPELPAADLTAAVESVPATYAPECLSACELAFHCRARSLESGAVTSLGRSVRAELGGLSTVEDVLSAARGESGDPDDPAVAALRRAARLRAEALGQEAVAGCR
>NZ_CP023689.1|WP_150502397.1|6199274_6200273_-|phosphatase-PAP2-family-protein
MPHADIAGVEATPRTRLRWWTELPLILLVYACYSAGRLLARGDVSTAVDHGLAILDIEKALYLNAEHPLNRLFTREPWIGVPADFWYASLHYLITPVLLVWLFRSRTVHYRAARTWLMTSTFIGLIGFTLLPTCPPRLLADGHGFVDTMAQYSSYGWWGGEASAPKGLGGMTNQYAAMPSLHVGWALWCGVILWRFGGTRLTKVAAVAYPLITTLVVMGTANHYFLDAAAGAAVMGAGLLLAPYVMRIMDRARARFGPGATPVAAPAGPASRGAGATVKVGSAATSSSIVSGGCQTSAGERIPRQRESRFASGAEPSASPQDAGDGAPAPAR
>NZ_CP023689.1|WP_150502399.1|6200460_6201057_+|histidine-phosphatase-family-protein
MAPRILLARHGQTAWSLSGKHTGRTDVPLLEEGRRGAKLLGERLHRPPYDRLDGVEVRTSPLSRARETCELAGFGDRARTWDTLMEWDYGAYEGMTPAEIQAIRPGWLIWRDGVPEGETLSEVTARADEVVTWARAADRDVLVFAHGHILRSIGARWLGLPLDFAARIRLNPTSLSVLGWAYDEPAIESWNDSGHLAG

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Crispr_ID: NZ_CP023689_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_14

6907920-6908023

Orphan

Consensus_repeat	Method
TTTTGGGGGCGCGGGGAACTGCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_14

>merge|NZ_CP023689|14|6907920-6908023|CRISPRCasFinder
TTTTGGGGGCGCGGGGAACTGCGCAACGGTTGTGTCGCATACGGTCACGTCTCGGCGCAGGCCCACTGCAACTCCTCTTCTTTTAGGGGCGCGGGGAACTGCGC

>NZ_CP023689|14|13|6907920-6908023|CRISPRCasFinder
TTTTGGGGGCGCGGGGAACTGCGC	AACGGTTGTGTCGCATACGGTCACGTCTCGGCGCAGGCCCACTGCAACTCCTCTTC
TTTTAGGGGCGCGGGGAACTGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150503078.1\|6905652_6907710_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|341045
NZ_CP023689.1\|WP_107906802.1\|6896998_6897436_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
NZ_CP023689.1\|WP_107906811.1\|6909768_6910215_-\|DUF1992-domain-containing-protein	unknown	unknown	gnl\|CDD\|378159
NZ_CP023689.1\|WP_150503071.1\|6899821_6901450_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|277335
NZ_CP023689.1\|WP_030957333.1\|6910312_6910705_+\|FHA-domain-containing-protein	unknown	unknown	gnl\|CDD\|238017
NZ_CP023689.1\|WP_107906810.1\|6909432_6909780_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150503082.1\|6908833_6909469_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150503065.1\|6895709_6895952_+\|DUF2277-family-protein	unknown	unknown	gnl\|CDD\|378364
NZ_CP023689.1\|WP_167537783.1\|6896125_6896830_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223659
NZ_CP023689.1\|WP_150503075.1\|6903456_6904134_+\|HAD-IA-family-hydrolase	unknown	unknown	gnl\|CDD\|319829
NZ_CP023689.1\|WP_150503076.1\|6904432_6905617_-\|peptidoglycan-binding-protein	unknown	unknown	gnl\|CDD\|366659
NZ_CP023689.1\|WP_150503089.1\|6916884_6918042_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|340391
NZ_CP023689.1\|WP_150503069.1\|6897526_6899455_-\|FAD/NAD(P)-binding-protein	unknown	unknown	gnl\|CDD\|379196
NZ_CP023689.1\|WP_150503073.1\|6902636_6903218_+\|TMEM165/GDT1-family-protein	unknown	unknown	gnl\|CDD\|225030
NZ_CP023689.1\|WP_150503087.1\|6914925_6916596_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378217
NZ_CP023689.1\|WP_150503080.1\|6908052_6908706_-\|dihydrofolate-reductase	unknown	unknown	gnl\|CDD\|223340
NZ_CP023689.1\|WP_107906805.1\|6901581_6902226_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|377857
NZ_CP023689.1\|WP_150503085.1\|6912920_6914972_+\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|379588
NZ_CP023689.1\|WP_150503083.1\|6911490_6912612_-\|DUF2330-domain-containing-protein	unknown	unknown	gnl\|CDD\|370813
NZ_CP023689.1\|WP_125529622.1\|6910717_6911389_-\|O-methyltransferase	unknown	unknown	gnl\|CDD\|226607

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150503078.1\|6905652_6907710_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.03975e-97
NZ_CP023689.1\|WP_107906802.1\|6896998_6897436_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.25585e-14
NZ_CP023689.1\|WP_107906811.1\|6909768_6910215_-\|DUF1992-domain-containing-protein	gnl\|CDD\|378159	pfam09350, DUF1992, Domain of unknown function (DUF1992). This family of proteins are functionally uncharacterized.	1.74384e-19
NZ_CP023689.1\|WP_150503071.1\|6899821_6901450_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|277335	cd07389, MPP_PhoD, Bacillus subtilis PhoD and related proteins, metallophosphatase domain. PhoD (also known as alkaline phosphatase D/APaseD in Bacillus subtilis) is a secreted phosphodiesterase encoded by phoD of the Pho regulon in Bacillus subtilis. PhoD homologs are found in prokaryotes, eukaryotes, and archaea. PhoD contains a twin arginine (RR) motif and is transported by the Tat (Twin-arginine translocation) translocation pathway machinery (TatAyCy). This family also includes the Fusarium oxysporum Fso1 protein. PhoD belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.17637e-32
NZ_CP023689.1\|WP_030957333.1\|6910312_6910705_+\|FHA-domain-containing-protein	gnl\|CDD\|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	0.00786909
NZ_CP023689.1\|WP_150503087.1\|6914925_6916596_-\|hypothetical-protein	gnl\|CDD\|378217	pfam09594, GT87, Glycosyltransferase family 87. The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM. The family also includes alpha(1-->3) arabinofuranosyltransferase, invloved in the synthesis of of mycobacterial arabinogalactan.	0.000188357
NZ_CP023689.1\|WP_150503065.1\|6895709_6895952_+\|DUF2277-family-protein	gnl\|CDD\|378364	pfam10041, DUF2277, Uncharacterized conserved protein (DUF2277). Members of this family of hypothetical bacterial proteins have no known function.	3.83631e-25
NZ_CP023689.1\|WP_167537783.1\|6896125_6896830_-\|hypothetical-protein	gnl\|CDD\|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	1.58932e-15
NZ_CP023689.1\|WP_150503075.1\|6903456_6904134_+\|HAD-IA-family-hydrolase	gnl\|CDD\|319829	cd07527, HAD_ScGPP-like, subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). This subfamily includes Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p). GPP1p and GPP2p are involved in glycerol biosynthesis, GPP1 is induced in response to both anaerobic and hyperosmotic stress, GPP2 is induced in response to hyperosmotic or oxidative stress, and during diauxic shift; overexpression of DOG1 or DOG2 confers 2-deoxyglucose resistance. These belong to the beta-phosphoglucomutase-like family whose other members include Lactococcus lactis beta-PGM, a mutase which catalyzes the interconversion of beta-D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), and Escherichia coli 6-phosphogluconate phosphatase YieH. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.06688e-72
NZ_CP023689.1\|WP_150503076.1\|6904432_6905617_-\|peptidoglycan-binding-protein	gnl\|CDD\|366659	pfam01471, PG_binding_1, Putative peptidoglycan binding domain. This domain is composed of three alpha helices. This domain is found at the N or C-terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.	3.26084e-10
NZ_CP023689.1\|WP_150503089.1\|6916884_6918042_+\|sensor-histidine-kinase	gnl\|CDD\|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	7.26465e-16
NZ_CP023689.1\|WP_150503069.1\|6897526_6899455_-\|FAD/NAD(P)-binding-protein	gnl\|CDD\|379196	pfam13454, NAD_binding_9, FAD-NAD(P)-binding.	4.34623e-45
NZ_CP023689.1\|WP_150503073.1\|6902636_6903218_+\|TMEM165/GDT1-family-protein	gnl\|CDD\|225030	COG2119, COG2119, Predicted membrane protein [Function unknown].	6.36716e-27
NZ_CP023689.1\|WP_150503080.1\|6908052_6908706_-\|dihydrofolate-reductase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	3.9168e-09
NZ_CP023689.1\|WP_107906805.1\|6901581_6902226_-\|HNH-endonuclease	gnl\|CDD\|377857	pfam07510, DUF1524, Protein of unknown function (DUF1524). This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	1.96264e-10
NZ_CP023689.1\|WP_150503085.1\|6912920_6914972_+\|DUF2029-domain-containing-protein	gnl\|CDD\|379588	pfam14378, PAP2_3, PAP2 superfamily.	1.54691e-44
NZ_CP023689.1\|WP_150503083.1\|6911490_6912612_-\|DUF2330-domain-containing-protein	gnl\|CDD\|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	6.22669e-81
NZ_CP023689.1\|WP_125529622.1\|6910717_6911389_-\|O-methyltransferase	gnl\|CDD\|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	2.13094e-57

>NZ_CP023689.1|WP_150503078.1|6905652_6907710_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MAGDAHGMTGNVRDAQPPDRRAPAHENVSGNVLVSIGALLLGMLLAALDQTIVSTALPTIVSDLGGLEHLSWVVTAYLLASTAATPLWGKLGDQYGRKRLFQIAIVIFLVGSALCGMAQDMAQLIAFRAVQGVGGGGLMVLSMAIVGDIVPPRERGRYQGLFGAVFGASSVLGPLLGGVFTEHLSWRWVFYINLPVGVVALVVIAAVLRIPHKATRHVIDYLGTFLIASVATCLVLVASLGGTTWAWGSVQIVGLALLGVVLAAAFVVVERTAAEPVLPLRLFRVRTFSLSAVISFIVGFAMFGAMTYLPTFLQIVQGISPTLSGVHMLPMVVGMLLASTGSGQIVSRTGRWKVFPITGTGVTVIGLLLLHQLEVDSSTWAMSVYFFVFGLGLGLVMQVLVLIVQNAVPYKDLGVATSGATFFRSIGASFGVAIFGTIFAARLDDKLVEAYRGVRLPQGVSLEGLEADPRGIAELPSGLRPAALEAYASSITDVFLYAAPVAVVGFVLAWFLREDKLRGSVTAPDVTETLASNPVERSSYDEVCRALSVLGTREGRREVYRTITERAGYDLLPAASWLLLRIKRYGWVEPGVLAERSTVPLPVILDAARQVEGRGLAVREGLEMVLSEKGRVVADRLARVREESLGELLGDWWGPERPTDLAQLVKELNAELCGSEREQPGGGGR
>NZ_CP023689.1|WP_150503076.1|6904432_6905617_-|peptidoglycan-binding-protein
MIAVSRYGLSSPIGIVPSGGLGREREERLHNLGSSRGRDERVTEPRGTNGAGDPQDPGSPNGHLCPECGTPRAADNTPSCGCGERASEALRDARTAEAAAAGDFDPLRIRPYVELEGDNAAETMQLRQVDPQQPAPPARAAADDAQTLATPLASGATTPNAQDLSLFESTPTQPTAPTDESDWDDVDEARGTGRRHRRTILLGAGGALVVVMTAAGLASGMFSYDAPSRKTALPHDVRASVPAPSTGEAETTAAPPETASGSAPAPTSASPSESPTESPSPTRSTSSPSPTPSTEPTKSPSPTEAATDPDEESPAARQPTPPVLSRGDRGPEVTELELRLTQLGLYTRQARGNYNEGVEDAVARYQWARGIQSDDYGVYDLETREHLESETTEP
>NZ_CP023689.1|WP_150503075.1|6903456_6904134_+|HAD-IA-family-hydrolase
MTATAAPTESTVITARALLLDMDGTLVNSDAVVERIWRRWAERHGLDGDEVMKVVHGRQGYASMALLLPDRPMEQNHADNARMLAEETADVDGVVPIAGAPEFLASLRGLPHALVTSADVALSTARMAAAGLELPDVRVTAESVGASKPDPEGFLKGAAELGVAPADCVVFEDSGAGIEAGRSAGMRVVGVGARAGFHGPDVLVRDLRQVRVEAVDGGGVRLVIA
>NZ_CP023689.1|WP_150503073.1|6902636_6903218_+|TMEM165/GDT1-family-protein
MISFTVTAVVFGVVFLAELPDKTALAGLVLGTRYRASYVFAGVAAAFAVHVALAVAAGSVLTLLPQQILHALTGVLFLGGAAVLLMKKDEDEGEVRKPENQSFWKVSGAGFMLILVAEFGDLTQIMTANLAARYDDPLSVGIGAVLALWTVAGIGILGGKALMKRVPLKLITKVAALVMLTLGVWSLYEAIAG
>NZ_CP023689.1|WP_107906805.1|6901581_6902226_-|HNH-endonuclease
MSKFYARRRVSILAALSGLIASVALFNAPTASAALPTPVSAATARTYLASLTVAAEDRTGYDRDLFPHWITQSGACNTREVVLKRDGTNVVQDSSCAATSGSWYSVYDGATWTAASDLDIDHLVPLAEAWDSGADSWTTSRRQSFANDLTRPQLIAVTDNVNQAKGDQDPATWMPSRTAYRCTYVRAWVQVKYYYGLSVDSAEKSALTNYLASC
>NZ_CP023689.1|WP_150503071.1|6899821_6901450_-|alkaline-phosphatase-family-protein
MAELRLGPLLRYIDGSTATVWVEASRPCAVRVRGADGSGGEARTFQVAGHHYALVPVTGLTPGTTTPYEVHLDGTGVWPLPGSPFPPSVIRTPADGDPVRLAFGSCRWAAPPADEKDPVGPDALDTLAARMAADPDGERPDVLVLLGDQVYADETSNATRRWLAARRDLSEPPGNEVADYEEYTRLYYESWLDPEVRWLLSTVPSCMIFDDHDVIDDWNTSAAWLADMRATPWWRERLLSGLMSYWVHQHLGNLSPAELAADPLFAAVREAPDGTDELRSFACKADADPASVRWSYRRDFGRVRLLMVDTRAARVLDEEARSMLDPGEARWLREQALEAPGSYDHLLIGTSLPWLLPHLVHDAEAWNAALCRGERGERWARFGEDLRRRADLEHWAAFPSSFDALTELIAEAGSGPDAPATVCVLSGDVHHAYIAEPAWPAGTGPDARVLQLTCSPVHNAIPLAIRLGFRFGWSGLARVLGRRFAGHGGCPKPPIDWRRTGGPWFGNQLMTLTLGRRSARLRLEQARGAARLDVVAESQLTP
>NZ_CP023689.1|WP_150503069.1|6897526_6899455_-|FAD/NAD(P)-binding-protein
MRPTRPGVTPLTAPTPAPTSVSVALVGAGPRGTSVLERLCACAPELLPPGARLTVHVIDPAPPGPGRVWRTAQSPELLMNTVASQVTLFTDESVDCSGPIRPGPSLYDWAAGELGPDEYPTRAQYGRYLEWVFAKVVREASPTVRVETYATRAVRLDDAPDGRQTLTLDDGRVLPGLSAVVLAQGHLPTAADTAQRHLAAHAERHGLRYVAPANPADVDLSAVSPGEPVLLRGLGLNFFDHMALLTTGRGGRFVRDDEGLRYLPSGNEPRLYAGSRRGIPYQARGDNAKGPYGRHLPLVLTPEVIAGFRKRADSGEAPDFLAEIWPLVAKEVETVYYAALIPGAGRPEFTERFLAVPHRDPQETLLLDEFGIPEGERWSWDRVSRPYGEYGFPDRGRWRDWLLAYLREDAAQAARGNVHGPLKSALDVLRDLRNELRLIVDHAGLTGTSRRDHLDRWYTPLNAFLSIGPPRRRVEELVALMEAGVVEVLGPRLEVREEADAWVAHSPEVPGSVVRATTLVEARLPEPDLRRTADELLARLLKTGQCRPHTVDGYETGGLDVTARPYRLIDRQGQPHARRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAALRAVIPGTEGDAGTQVWPNVELASID
>NZ_CP023689.1|WP_107906802.1|6896998_6897436_-|DoxX-family-protein
MTGRLNSAQPYAIGLFRIVVGLLFACHGANSLFGAFGGETPDTGAWPAWYAAVIELVGGSLVLLGLGTRAAAFISSGAMAYAYFKVHQPQALWPIENSGEGAAMYCWAMFLLIFTGSGAFGLDRLFTKRSTAQSSTATDQTPVAA
>NZ_CP023689.1|WP_167537783.1|6896125_6896830_-|hypothetical-protein
MAVIGRPCRSPRTSRHGSGHGGKRGVAVLEGIEDVGALTASPWIYVVVAVSVLLDVFVPVLPSGVLVITAATAAAAGSGAATGEVPGEVPDILALTLCAATASVLGDLVAYRVARRGGARLDRAIARSRRLSAAQERLGAALARGGGALVVLARFAPAGRSVVSLGAGATHRRVRDFLPWSALAGLAWAVYSVALGYFGAQWLGATWLATAVSVAALFAAGAGATYLVRREPSA
>NZ_CP023689.1|WP_150503065.1|6895709_6895952_+|DUF2277-family-protein
MCRSIKTLRPPVLPEEATEEDIRAAALQYVRKVSGFRAPAAHNREVFDRAVEAIAEATAELLDGLEVRGAPATARGAAAG
>NZ_CP023689.1|WP_150503080.1|6908052_6908706_-|dihydrofolate-reductase
MSLVRVHNFTISLDGFGTGEGLSLDAPFGHAGERLHEWMFATRWWRERTGESGGNGGVDDAFARQFMPGIGAEIMGAGKFGYPGWHENPDWKGWWGPNPPFHTPTFIATQHTRPSIEMEGGTTFHFLNASPAEVLAAARKAAGDQDIRIGGGVRLLRDFLSARLIDHAHIVVSPILLNRGQRLWDGLEGLEQHYATESISSPSGVTHLTLTLRDQTV
>NZ_CP023689.1|WP_150503082.1|6908833_6909469_+|hypothetical-protein
MSTVVIILIVIAAVVVLGVTVMALRTRGAQGGRSLKRRFGPEYERTVARHDGDAKAAERELAQRVERHGGLRERTLETTEVERYEARWTAAQERFVDSPKGAVDEADRLLAELAQARGYPDGAQYEEQLSALSVHHANRVRGYRRVHRAARAGAEGGPGTEEMREAMVEARALFEELVAVPVERHREPHEAQEKTGSHTPWSFTGRQAKGS
>NZ_CP023689.1|WP_107906810.1|6909432_6909780_+|hypothetical-protein
MVVHGASGEGELSHMTDVTTGSGPGHVRLVPDDESDKFELRLQHAVSGFVDGPRAAVEEADQVVEAIVARFAETVRERRRTLRTSWQDTEEKADTERLRLALRDYRELAERLLHI
>NZ_CP023689.1|WP_107906811.1|6909768_6910215_-|DUF1992-domain-containing-protein
MTERKPPGVPFESWVDKQIHDAQVRGDFDRLPGRGEPLPNDLEAPYDELWWVKRKMAREGLSVLPPALALRKEAEDALTAAYAAPSERAVRKIITDVNAKIRDMLLKPPPGPPLGRKPYDVEEVVRQWRERRATAGSGAPDGSRASDV
>NZ_CP023689.1|WP_030957333.1|6910312_6910705_+|FHA-domain-containing-protein
MLELTMAAVSAADEGATAGMLMADAPSEPGAVLRVGRDKQVCRLSTPDDWLFVSRVHLEFLCGPDGGWQVSWLRGSQPDPSSEVRLTVGEYAQPIAYGGSVPLPRGGSGEIVIHDRTAPRSVNVGFYHEA
>NZ_CP023689.1|WP_125529622.1|6910717_6911389_-|O-methyltransferase
MSESQVWDDVDEYFSSQLSPDDEILLAALRDSEAAGLPAISVTATQGKLLQLLAQIQGARNILEIGTLGGYSTIWMARALPSDGRLISLEYSARYAEVASRNIARAGLDKVVEVRVGPALESLPKLADENPAPFDLVFIDADKANNPHYVDWALRLTSTGSLIVVDNVVRGGRVVETDSDAPDVRGTRAAIELIGSHPRLSGTAIQTVGGKGYDGFALARVLA
>NZ_CP023689.1|WP_150503083.1|6911490_6912612_-|DUF2330-domain-containing-protein
MAESLRQGARGRALAVVLALLALQLGQLVAPAWACGCGAMVPGDARRVAVGREESVVRWDGAREQVVMRLTVDGDAERVAWIMPVPGRATVRLGDPALFDELHAVTAPVHRTRHHFWPQDGDWPLVAGDGAAGAPPPPGAGAPVGVVGRQRLGPFEVARLTATDPAALDGWLDANGFALPPRLADALRPYVDRRWEYVAVKLTPRAGGTALTGALDPLHLTFRTDEPVYPMRLSRLAATPQSLGLYVLAAHRMEPASRIGGERPRVTYAGRVTARTGPLAELAAGAPFLTAIGQEFPSPERISGDHVLRRAAADDTFQQVIHEDRLRTLAGVPLWLLTVTTALAAAIAAAVVFAVRRTRPRLAEVPRPPAPTG
>NZ_CP023689.1|WP_150503085.1|6912920_6914972_+|DUF2029-domain-containing-protein
MANADHGGRPEAIGATAVGAVQARVRVARLGLWLIVAVLALREVAVVLGTPRGERLTDLETWVGPDGVLHVKGSLYDSTEFTGTPFGGLVLKPLTRAAEQALGWGWTFGTLLLVVVLGLVAARALPQPVSRRTSLLAAPVAISLLMLSLPVRNTLYLGQTSIMPVLLVLLGCFAVRGERASGVLIGVAAALQPTLLLFTPLLWFTGRRRAALSTGATFAACTALAWVAMPSDSYTYWVHHMAGVGLGGRADDLGNQSLHGALLRLGLTGPLEIVLFLLLGAGVAALAVRRAVRYAHDGQLLLAVAITGCAAIVVSPTAWQHQLLWVLLAVVGQVGRRASDRYVWPVAIVLVMTLPAKMMVPDKLILHPLRADLVLLAAIAAAAVVPFLSRASPYWQTPVPTRYADKVPARFRHIPLVPFLRRVISRPNLLFELLLIRVTYYAYAQIRLAAAGGSNSAGRITAEEHGEEIHSVERALGIDIEHWANHAVVQVDWLRGFFDFYYESFHFGVPLAILAVLYWRRPVDYRWARTAIGFATVFALIGFWLYPLAPPRLMPGLGFIDTVHGPQDFTQPDYGTLTELTNQYAAMPSLHFGWSLWCGLVILILAPRWWMKALGLLHPLFTVTAIVVTGNHWVLDAVGGAAVVGAGFAVTYLFQGPRAKTVTARAEKVSSDSRAPVKDRTPS
>NZ_CP023689.1|WP_150503087.1|6914925_6916596_-|hypothetical-protein
MNVPTRNRVLAHMVPAELTRTRPAPPASEAGQSLPRTLWHRHRVPLLATLPALPLYAIWWAFLATGGGDLAAQYAWAGFAARHGDSAYNLFWYGGTHTANYSLISPYLMAAVGVRALTVVSGIAATWLAAVLMERAGLRRPLGPALLASFALWCNVASGRTTFALGVAFGLAACLMLTRDRRIVLAAAYAALATMASPVAGLFLVVVGAAFLVTRDWPRALALLLPPALTVGLTTLLFPFKGEQLMFAGRIWPPFLFGLAVTFLAPRSWRVARISGAVYAAGTVLTYLIASPIGTNVERFAELFAPAALLAVLLAQPQLAKVRRNLLVTALVLSVAWVGKKTADDLYVSTTVPAWAAETDGVVRALDHLGADRTRVEVVPARNHREASGLAPHVNMARGWNRQLDMERARLFYDGSFSATTYRAWLDRWAVGFVVLPLGKPDGYAKVEAQLVRENRPAWLEPVWQDAHWKVFRVRDAQPLVSEPATVVSTSSVDVVVRMSRPGSATVRIAYSQWLRTDGGGCLKPQGEFTRLTVSAPGEYRISSEYGPSPEPGSRC
>NZ_CP023689.1|WP_150503089.1|6916884_6918042_+|sensor-histidine-kinase
MTQYVMDPAIWGLVVGAPAAATIIVRQQKAIRKLRKRNDELKSSYVDLEGGYDAIVRQTEERAGEETKTVLKSAMRTLQGLAAEQQLVISKLQSKYGDSPILRDLLEIDHMNSQFGRRAQSIAVLCQGWLGRQRDPASVYDVIRSAQGRIRHYQRVEILSQVDYGVTSRAVESIALAVAELLDNATSYSAPETVVEINVRSVPKGICIVVDDAGVGMNEEEKARAAELLSGERAASVSDLGNPPQFGFAVIGALCERYGFTVSVDSTSPYGGVRAVVLVPEELLTSMPEPKIPNAAVHADAQADELGGDAPATTSDGLPKRRRKQRPMAVVPSSGGTARSPGRSTEETASIMSAFQRGTQTGRAAPLDAMRGSHADGRKGPETTS

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Crispr_ID: NZ_CP023689_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_15

6958258-6958375

Orphan

Consensus_repeat	Method
CCTGCGGCTGCCCACCGTAGGGCTGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_15

>merge|NZ_CP023689|15|6958258-6958375|CRISPRCasFinder
CCTGCGGCTGCCCACCCCCGAACGGCTGCCCGGCCTGCGGCTGCCCACCGTAGGGCTGCGGCTGCTGGGCGCCCGGGTACCCGTAACCACCCTGCGGCTGCCCGCCGTAGGGCTGCGG

>NZ_CP023689|15|14|6958258-6958375|CRISPRCasFinder
CCTGCGGCTGCCCACCCCCGAACGGCTG	CCCGGCCTGCGGCTGCCCACCGTAGGGCTGCGGCTGCTGGGCGCCCGGGTACCCGTAACCAC
CCTGCGGCTGCCCGCCGTAGGGCTGCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150503150.1\|6970175_6971396_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
NZ_CP023689.1\|WP_150503126.1\|6949548_6950949_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
NZ_CP023689.1\|WP_150503124.1\|6948717_6949338_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380056
NZ_CP023689.1\|WP_150503144.1\|6965457_6966921_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|129794
NZ_CP023689.1\|WP_150503138.1\|6961040_6961574_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150503130.1\|6951709_6952780_+\|prenyltransferase	unknown	unknown	gnl\|CDD\|273702
NZ_CP023689.1\|WP_150503142.1\|6963484_6965245_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341047
NZ_CP023689.1\|WP_150503132.1\|6954576_6956139_+\|solute-binding-protein	unknown	unknown	gnl\|CDD\|379243
NZ_CP023689.1\|WP_030956222.1\|6962710_6963361_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379276
NZ_CP023689.1\|WP_150503128.1\|6950942_6951713_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_CP023689.1\|WP_126904192.1\|6966973_6967516_+\|SigE-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|132028
NZ_CP023689.1\|WP_125528684.1\|6948199_6948433_+\|ferredoxin	unknown	unknown	gnl\|CDD\|224064
NZ_CP023689.1\|WP_150503134.1\|6956914_6957925_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274647
NZ_CP023689.1\|WP_107907366.1\|6968414_6969047_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP023689.1\|WP_150503148.1\|6969487_6969949_+\|SRPBCC-domain-containing-protein	unknown	unknown	gnl\|CDD\|176856
NZ_CP023689.1\|WP_125528679.1\|6956125_6956899_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107906837.1\|6952794_6953082_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150506980.1\|6953311_6954580_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_150503140.1\|6961692_6962646_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|376559
NZ_CP023689.1\|WP_150503146.1\|6967512_6968352_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150503150.1\|6970175_6971396_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	3.16971e-42
NZ_CP023689.1\|WP_150503126.1\|6949548_6950949_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	5.13118e-67
NZ_CP023689.1\|WP_150503124.1\|6948717_6949338_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380056	pfam17925, TetR_C_20, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the transcriptional regulator KstR that regulates a large set of genes responsible for cholesterol catabolism. This is important for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma.	5.30881e-40
NZ_CP023689.1\|WP_150503144.1\|6965457_6966921_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.43226e-69
NZ_CP023689.1\|WP_150503130.1\|6951709_6952780_+\|prenyltransferase	gnl\|CDD\|273702	TIGR01577, Uncharacterized_glycosyl_hydrolase_MJ1610, oligosaccharide amylase. The name of this type of amylase is based on the characterization of an glucoamylase family enzyme from Thermoactinomyces vulgaris. The T. vulgaris enzyme was expressed in E. coli and, like other glucoamylases, it releases beta-D-glucose from starch. However, unlike previously characterized glucoamylases, this T. vulgaris amylase hydrolyzes maltooligosaccharides (maltotetraose, maltose) more efficiently than starch (1), indicating this enzyme belongs to a class of glucoamylase-type enzymes with oligosaccharide-metabolizing activity.	4.79147e-14
NZ_CP023689.1\|WP_150503142.1\|6963484_6965245_-\|MFS-transporter	gnl\|CDD\|341047	cd17504, MFS_MMR_MDR_like, Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.40613e-74
NZ_CP023689.1\|WP_150503132.1\|6954576_6956139_+\|solute-binding-protein	gnl\|CDD\|379243	pfam13531, SBP_bac_11, Bacterial extracellular solute-binding protein. This family includes bacterial extracellular solute-binding proteins.	1.12448e-11
NZ_CP023689.1\|WP_030956222.1\|6962710_6963361_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379276	pfam13578, Methyltransf_24, Methyltransferase domain. This family appears to be a methyltransferase domain.	8.69276e-22
NZ_CP023689.1\|WP_150503128.1\|6950942_6951713_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	6.47723e-27
NZ_CP023689.1\|WP_126904192.1\|6966973_6967516_+\|SigE-family-RNA-polymerase-sigma-factor	gnl\|CDD\|132028	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family. This group of similar sigma-70 factors includes the sigE factor from Streptomyces coelicolor. The family appears to include a paralagous expansion in the Streptomycetes lineage, while related Actinomycetales have at most two representatives.	2.13923e-48
NZ_CP023689.1\|WP_125528684.1\|6948199_6948433_+\|ferredoxin	gnl\|CDD\|224064	COG1141, Fer, Ferredoxin [Energy production and conversion].	3.3764e-09
NZ_CP023689.1\|WP_150503134.1\|6956914_6957925_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274647	TIGR03559, F420_Rv3520c, probable F420-dependent oxidoreductase, Rv3520c family. Members of this protein family are predicted to be oxidoreductases dependent on coenzyme F420. The family includes a single member in Mycobacterium tuberculosis (Rv3520c/MT3621) but four in Mycobacterium smegmatis. Prediction that this family is F420-dependent is based primarily on Partial Phylogenetic Profiling vs. F420 biosynthesis. [Unknown function, Enzymes of unknown specificity].	1.89995e-167
NZ_CP023689.1\|WP_150503148.1\|6969487_6969949_+\|SRPBCC-domain-containing-protein	gnl\|CDD\|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	9.29495e-30
NZ_CP023689.1\|WP_107907366.1\|6968414_6969047_-\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.01872e-61
NZ_CP023689.1\|WP_150503140.1\|6961692_6962646_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|376559	pfam01520, Amidase_3, N-acetylmuramoyl-L-alanine amidase. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.	7.86003e-41

>NZ_CP023689.1|WP_150503134.1|6956914_6957925_-|LLM-class-F420-dependent-oxidoreductase
MRLGLALGYWGRGPSPDHVPLAQEAERLGYDSVWTAESWGSDAFTALTWIAARTSTIRLGTAVAQMAARSPTTTAMHALTLDHLSGGRMMLGLGLSGPQVVEGWYGRPFPKSPLTATREYVDVVRQVLRREGPVALDGRFHSHPYSGPDGTGIGKALKPITHPLRADLPVLLGAEGPKNVAQTIRIADGWLPLYWSPSRPDVYGEAVAELPEGFVVAPMARVQVCDDVSEGLLPVKAMLGFYIGGMGHAARNFHADLMARMGYEEEARRIQELFLSGRKEEAVLAVPDAFADEISLVGPRERIAERLELWRKGPVTDLLVLSPDRPTLRLLAELNS
>NZ_CP023689.1|WP_125528679.1|6956125_6956899_+|hypothetical-protein
MGVIDSQWWSLRWPWMVVWLLTAVCVAVVAQYVVARWVAARRRRRVRDGRMFSGMCIYLHETRVEGVADILGIPKADVNVSHETSVSTGFGLFGRFTVGGRAERDTNTQTRREYWEPNTPMKTIRLIMDRLRARDMVVDADLATGQLFLTAALADELRGAEARGTPLTAVRGTYVSVSGLFTVRRDGEDVVLHARYGTGEPRAQVKITCETSWVREEEFRVDRYSADEEFPATCLGRVRAWNATTGELTLDPISVFQ
>NZ_CP023689.1|WP_150503132.1|6954576_6956139_+|solute-binding-protein
MKRRTLTACLTLTLLAALTSCGGGDEDITLRVLASPELADLEPLLGDLKDDTGVELDMDYRATADLSGARGSSYDLAWPASDRSFLLRLQDKGERAARPESTPIMRSPVVVGLTPRTADTLTARAPDGRLSWADIADAAADGTVRFGMADPRSSDTGRAALVGVATAAAGTGSALREQDVSCDRLRGFRSGQTLTGASSRELIAAYPGHQGEANALIAHESELLSLNASKKLREPLRIVHPDDGMVLSDFPLLLLDADERGAYRKVVDWLLKDDVQRELMRRTWRRPVNQDVTPAEPLREAVGNALSYPDRLSIVERLVADYGDPASATTDQVVFLLDFSGSMRGERIAGLRAAFAGLSGADPTSTGKFARFYRGEHLTVVRFGERVLQERTVTVRGDGDLRALGKVVAAGSFDDFTAVWSALDRGYRIATDAVREAPERPVAIVLMTDGESNAGISYAEFLRRYERLGADAREVPTFPVHFGEADAAALDKAARATGGRMVDADESSLSDAFKEIRGCH
>NZ_CP023689.1|WP_150506980.1|6953311_6954580_+|hypothetical-protein
MRTRDRNRPRARLPVHVLLALPLALAGLIALLVTGNALRPFDRVVTIEARMASKSDYFKDPEVQRLLLKHGLRVDIHRLGSRGIATQSLTGMDAVFPSGQPAAKLILDRQDRSVRSVRPFVTPLVLGTFRAYAETLEKMGVATAQPPAGGGRALYYDLDMDRFMGLLDGRTGTKDQTLTGDQDRDGVTERADTWNGIGFDRPGGRSNSGRVLVRTSSVCESNSAGAYLSILAFVANGDSTPGAGQADETKAMEEARTVARKIKPLIDLQGMWADEQADSYLSDLGESIAPISLIYEHQYLAHQIAHEREHGEADTDRVLLYPTPYALTEPQLISLSGEGDRLVRVIQDDPELRRRAIELGFRVRFSGEDGTSDQLNAYLADHGIQVPRPNRDETKVYEPDLDVLEEIIDSVGTCPPAVRDTP
>NZ_CP023689.1|WP_107906837.1|6952794_6953082_-|hypothetical-protein
MSPRYSSNQAGRVIAIVADVMALILGLWILMYLLDANPANDFVQFVHDAARWLAGWSHDLFTFDEEWARVVAGYGLAAVVYLFVGHAIAGRVHRH
>NZ_CP023689.1|WP_150503130.1|6951709_6952780_+|prenyltransferase
MTTPRTEHLVLPGVLTAEEAAATVAGILAVQREDGAIPWFRGHHLDPWDHVEAAMALDTAGEHAAAERAYTWLATHQNDDGSWYAAYADGAFDDVTDTGRETNFVAYIAVGVWHHYLSTGDDTFLDRMWPSVHAAIEFVLQLQQSGGQIGWRRDEDGTANPDALLTGSSSIHHALRCALAIAEQREEPQPDWELAAGALRHAIRRHPERFLDKDRYSMDWYYPVLGGALTGAEAKSRMEEGWERFVVPGLGVRCVVPNPWVTGGESAELALALWAMGESDRALDILQSIQHLRDAESGLYWTGYVFEDQAIWPRELTTWTAGSLLLAVAALGGHEATCAVFGGDRLPAGLDPDCCG
>NZ_CP023689.1|WP_150503128.1|6950942_6951713_+|methyltransferase-domain-containing-protein
MLTVDFSRFPLAPGDRVLDLGCGAGRHAFECYRRGAQVVALDQNGEEIREVAKWFAAMKEAGEAPEGATATAMEGDALALPFPDESFDVVIISEVMEHIPDDKGVLAEMVRVLKPGGRIAITVPRYGPEKVCWALSDEYHEVEGGHIRIYKADELLAKIRGAGLKPYGTHHAHALHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPLATRVAEQALNPLIGKSFVAYATKPHLPRLSETPETSETSEAAAK
>NZ_CP023689.1|WP_150503126.1|6949548_6950949_+|glycosyltransferase
MTAGAREAAASEDLAADGERPLDIALLTYKGNPFCGGQGVYVRHLSRELARLGHRVEVIGSQPYPVLDEGAEYAGRLTLTELPSLDLYRQPDPFRTPGRDEYRDWIDALEVGTMWTGGFPEPLTFSLRARRLLRARSGDFDVVHDNQTLGYGLLGDVGAPLVTTIHHPITVDRQLELDAADGWRRRMSVRRWYAFTRMQKRVARRLPSVLTVSGTSRQEIVDHLGVAGDRVHVVHIGADTDLFSPDPSVRRIPGRIVTTSSADVPLKGLVFLVEALAKVRTEHPDAHLVVVGKRPTEGPVAQAVERYGLEGAVEFVKGISDAELVDLVRSAEVACVPSLYEGFSLPAAEAMATGTPLVATTGGAIPEVAGRDGETCLAVPPGDAGALAAGLSRLLGDPELRVRLGSAGRERVLRHFTWARAAEGTVARYREAVARSAGPTPDRSAAPQTFAPKQLAASNPEGRASC
>NZ_CP023689.1|WP_150503124.1|6948717_6949338_-|TetR-family-transcriptional-regulator
MPAEASSASPSSPPLTERQEARRRRILHASAQLASRGGFDAVQMREVAESSQVALGTLYRYFPSKVHLLVATMQDQLEHMHGTLRKKPPQGATAAERVAETLMRAFRALQREPHLADAMVRALTFADRSVSPEVDQVSRQTTVIILDAMGLENPTPEQLSAVRVIEHTWHSALITWLSGRASIAQVKIDIETVCRLIDLTSPEGRE
>NZ_CP023689.1|WP_125528684.1|6948199_6948433_+|ferredoxin
MGDRWQVEVDRSVCIGSAQCVHHAPDGFRLDTGRQSHPADPETDANERILAAAESCPVEAIVITLLGSGEPVFPPEE
>NZ_CP023689.1|WP_150503138.1|6961040_6961574_-|hypothetical-protein
MGDQLNFQTAQRGVIIAGLSVSLLGMGTSAQATPSAKSSEVASGNRAIIAKRLIHVRSIGTKCGKTPVAMASGRGRMTLRIDDTRSTGTVLSKHIDASKGVISAGVGWDVSKSRSITVSGSKEVPRGKHGTLTAFVKYSGKKFDVQAMLVPQGDKWIVQRNKTAYKPIGVCFKYSER
>NZ_CP023689.1|WP_150503140.1|6961692_6962646_-|N-acetylmuramoyl-L-alanine-amidase
MSYVGPDFDPPQPRRGRRRVLTVGLAALVPGALLGWVMYEAVGGDGGGSGNAAVQPSQAPSDQAPTDSTTSDDKPPGPTPTTDSTSAPAGSGSGSLDGKVVVIDPGHNPNNFRHTSEINRKVNIGTNWKECDTTGTSTNDGYSEAEFTLDVAHRMRTLLEKQGATVKFTQDGDRSWGPCVDERAEIGNKAHADAVVSIHADGAGSGQRGFHVILPGKVDEGAANTGPIVAPSRALGERIAGSFVRVTGDAPSNYIGDGTGLVTRKDLGGLNLSTVPKVFIECGNMRDSKDAAQLTSGAWRQKAAQGISEGIVSFLVK
>NZ_CP023689.1|WP_030956222.1|6962710_6963361_-|class-I-SAM-dependent-methyltransferase
MAPAPKPEILAAFEAAKGFMPTGEGLALHAAAVEAGRLGLPLLEVGTYCGRSTILLADAAREAGVTALTVDHHRGSEEQQPGWEYHDPETVDPAIGLMDTLPTFRRTLHAAGLEEHVIALVGRSPQVAKVWGTPLGLVFIDGGHTDEHANADYEGWAPHVAEGGLLVIHDVFPEPEDEFTGQAPYRVYLRALESGAFTEVSVTDSLRVLKRTGTGI
>NZ_CP023689.1|WP_150503142.1|6963484_6965245_-|MFS-transporter
MTRTTNEQPIGRADTGTPGPSGALVPVLAFAGIVVAVMQTLLVPVIKDLPQLLGTEPSNATWVLTSTLLSGAVATPIMGRLGDLYGKRRMLIASLSVMVVGALISAFTSALLPMIVGRTLQGFAMGAIPLGIGLMRDMLPREKLGSAMALMSSSIGVGGGLALPAAALVAQHSNWHALFYGAAGLGVLSIALTPLVVPESKVRAEGTFDGLGALGLSVGLVLFLLPITKGSDWGWTSATTLGMFAGSAAVLLLWGVYELRSKAPLVDLRTTARPAVLFTNLASIMVGVSFYVVSLVLPQLLQLPKATGYGLGQSMVVAGLLVAPLGLTMMFTAPVYARLSAKYGPKTTLILGMLIIAIGYGAGLGLMSAAWQSLVIAVVLGAGIGLAYSSLPALIIGAVPASETGAANGLNTLMRSIGTSVSSAVIGMVLANTANNVGGVAIPTMHGFRVSFLIATAAVAVGLLLALFLPKQRPAAHTQLRASSEEDANLERAEEALRGFRGRVLDAGGTPVARAKVTLIDRRGRQAGATLSADDGSYALAVPAQGAYVLAARADGHAPLASSATHTGDDSPVDLDLSLPGETVTA
>NZ_CP023689.1|WP_150503144.1|6965457_6966921_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MTPMLEAADVTRAPRRPAPPTWLVVALACAGQFLVVLDVAVVNVALPSMRADLGMDAQGLQWVVNAYAIAFAGFMLLGGRAGDLYGRKRMFLVGLGLFTLASLAGGLAQQDWQLLAARGVQGLGAAVLAPSTLTILTAAVPEGAARARAIGTWTAVGAGGGAAGGLVGGVLVDLLSWRWVLLINVPVGAVVLGGAVLWLAESRAGEGRRLDLPGAVLVTAGLATLAFGISQTEAAGWTAPDTVVPLLAGLALIGAFLAVEARTAAPLMPLGLLRVRAVASANAAMFLCGSAMFCMWFFMTLYSQNVLHYTPLEAGLALAPSSLAVVLGSKLAPRLMRGAGPRAVAVTGTLVAAVGFGWQSMLSVDGGYVTSIMVPGILMMLGAGLATPPLASLAMSGARPEEAGLVSGLVNTSRTMGGSLGLAVMSTIAAARSEGSGAPGALTEGYALVFRTSTVVLLVGAVLMLVWLPRKTAAVSPEAASVSSSAN
>NZ_CP023689.1|WP_126904192.1|6966973_6967516_+|SigE-family-RNA-polymerase-sigma-factor
MGDRKAARDSEFQSFVIGRWPRLLRTAFLLTGEQHAAEDLVQSTLEQVYVAWRRVGSADDPEAYVRRVMINAHARKHRRRLREFLAPKDDSGLAREVPDTGDRIAQAEDRDALLTALAQLPPRQREAVVLRYWEDLTETQTAEAMGCSVGAVKSNAAKGIAKLRAIPGLAEMVTQGGRSR
>NZ_CP023689.1|WP_150503146.1|6967512_6968352_+|hypothetical-protein
MSADRETNHGMTSHDMTHTDIALLLADAADEVEIGIAPYDAVLRGGRRRRARRWAVATATALVLVGSAGTLAVAGIPGGDGDRGATLATSPPTEPAPDVRTPARTLLALGTDAGKDWRVYLDVWEAPRNEREAREERGAMAEFGHIPSDLRDASDLIGRSSYFVRREYGDATSDQVLIEDAFTAEDNMSGKDIEAVSVPLEPGSGSGPERLVVGQVAVTARSVSCTWQDGSKTEVPVVSEAGDYNSDDFVIRPADGSPVNWFVCLAPKGTEYKSVAVTR
>NZ_CP023689.1|WP_107907366.1|6968414_6969047_-|response-regulator-transcription-factor
MPRDHRPTKSIRVLLAEDQGMMRGALALLLGMEPDITVVAQVSAGDTIVDAALTHRPDVALLDIELPGLSGLDAAAELRDQVPDCRVLILTTFGRPGYLRRAMEAGAAGFLVKDGPVEELAVAVRRVLTGETVIDPALAAAALSAGPNPLTARERDVLNASTEGATVADIAGKLHLSESTVRNYLSSAIGKTGTRNRMEALREARQQGWL
>NZ_CP023689.1|WP_150503148.1|6969487_6969949_+|SRPBCC-domain-containing-protein
MMTHDGGLRLHLQRVFRARRPVVFRALTEPLELTKWWGPDGFVITSVESDLRPGGGYRIAMQPPEGDLFYLVGEFLEVDPPARLSYTFRWEDPDPEDRETVVTLSLRDIGGTRAELAISQGDFATERRQALHVEGWTQSLNKLEELMSSAAPA
>NZ_CP023689.1|WP_150503150.1|6970175_6971396_-|sensor-histidine-kinase
MAWLRKTRGTSCETFRDERSPNGFSLLPWLLMGMGAFSNLFQGETPDPWIGGLGLLTFNSLYVYVSFRSFAKETREATSTRVALALLGLVTCALALAYGGNWLLFFPLLGLATGAAVRMPQLRPVGLVVGVLAGGVSVFHDGWGGLDIAYATWISTMVTAAILSLSEAVRQLRTAREELARRAVEEERLRFSRDLHDLLGHTLSVIVVKSEAARRLAEGDVAAAQAQLNDIEAVGRQALTEIREAVTGYRQGTLRDELDRAESALRAAGIEPVVRRSGSPLVPQTEALLGWVVREAVTNVVRHSGAARCEIVVAGSGGERVRLTVTDDGGGGGQRGAGSGIGAGAGAGAGAGTGLKGLTERLAAAGGTLTAGSGPREGFVVTAELPVEARGLVEERVEVGVGSPVG

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Crispr_ID: NZ_CP023689_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_16

7128401-7128495

Orphan

Consensus_repeat	Method
GCAGCTGCCCGTAACGGTTCCGC	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP023689_16

>merge|NZ_CP023689|16|7128401-7128495|CRISPRCasFinder
GCAGCTGCCCGTAACGGTTCCGCACGGCCCCGCGCCCCCAGGACAAGGGCGCGGGGATCCCGCGAGATCTATGCAGCTGCCCGTAACGGTTCCGC

>NZ_CP023689|16|15|7128401-7128495|CRISPRCasFinder
GCAGCTGCCCGTAACGGTTCCGC	ACGGCCCCGCGCCCCCAGGACAAGGGCGCGGGGATCCCGCGAGATCTAT
GCAGCTGCCCGTAACGGTTCCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_107906974.1\|7131553_7132738_-\|MarP-family-serine-protease	unknown	unknown	gnl\|CDD\|379142
NZ_CP023689.1\|WP_150503330.1\|7137460_7138441_-\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP023689.1\|WP_125530044.1\|7134253_7135000_+\|peptidoglycan-recognition-protein	unknown	unknown	gnl\|CDD\|128941
NZ_CP023689.1\|WP_107907380.1\|7136595_7136799_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_030944407.1\|7124656_7125622_-\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|235493
NZ_CP023689.1\|WP_107906970.1\|7125726_7126524_-\|lipoyl(octanoyl)-transferase-LipB	unknown	unknown	gnl\|CDD\|184638
NZ_CP023689.1\|WP_150503332.1\|7138518_7141221_-\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	unknown	unknown	gnl\|CDD\|236500
NZ_CP023689.1\|WP_150503324.1\|7130019_7130925_-\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|273800
NZ_CP023689.1\|WP_150503320.1\|7126805_7128284_+\|regulator	unknown	unknown	unknown
NZ_CP023689.1\|WP_150503326.1\|7130995_7131496_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_CP023689.1\|WP_150503318.1\|7123450_7124152_-\|DUF4191-family-protein	unknown	unknown	gnl\|CDD\|379389
NZ_CP023689.1\|WP_150503328.1\|7135289_7136429_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	unknown	unknown	gnl\|CDD\|367067
NZ_CP023689.1\|WP_030951856.1\|7136837_7137356_-\|DUF4240-domain-containing-protein	unknown	unknown	gnl\|CDD\|379426
NZ_CP023689.1\|WP_030951853.1\|7141482_7142112_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
NZ_CP023689.1\|WP_150503316.1\|7117777_7118695_-\|zinc-metalloprotease-HtpX	unknown	unknown	gnl\|CDD\|179418
NZ_CP023689.1\|WP_150506998.1\|7118870_7119386_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_125528401.1\|7122884_7123352_+\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
NZ_CP023689.1\|WP_125528402.1\|7121275_7122685_-\|type-I-glutamate--ammonia-ligase	unknown	unknown	gnl\|CDD\|273198
NZ_CP023689.1\|WP_107906968.1\|7124199_7124400_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_125528403.1\|7120900_7121167_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150503318.1\|7123450_7124152_-\|DUF4191-family-protein	gnl\|CDD\|379389	pfam13829, DUF4191, Domain of unknown function (DUF4191).	2.34896e-106
NZ_CP023689.1\|WP_125530044.1\|7134253_7135000_+\|peptidoglycan-recognition-protein	gnl\|CDD\|128941	smart00701, PGRP, Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member of this family, Tag7, is a cytokine.	7.46648e-50
NZ_CP023689.1\|WP_030944407.1\|7124656_7125622_-\|lipoyl-synthase	gnl\|CDD\|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	0
NZ_CP023689.1\|WP_107906970.1\|7125726_7126524_-\|lipoyl(octanoyl)-transferase-LipB	gnl\|CDD\|184638	PRK14345, PRK14345, lipoyl(octanoyl) transferase LipB.	3.44233e-112
NZ_CP023689.1\|WP_150503332.1\|7138518_7141221_-\|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type	gnl\|CDD\|236500	PRK09405, aceE, pyruvate dehydrogenase subunit E1; Reviewed.	0
NZ_CP023689.1\|WP_150503324.1\|7130019_7130925_-\|TIGR01777-family-protein	gnl\|CDD\|273800	TIGR01777, Hypothetical_UPF0105_protein_Rv2216/MT2273/Mb2239., TIGR01777 family protein. This model represents a clade of proteins of unknown function including the E. coli yfcH protein. [Hypothetical proteins, Conserved].	3.15692e-128
NZ_CP023689.1\|WP_150503326.1\|7130995_7131496_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.46069e-19
NZ_CP023689.1\|WP_150503328.1\|7135289_7136429_-\|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	4.0703e-24
NZ_CP023689.1\|WP_150503330.1\|7137460_7138441_-\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	2.72114e-44
NZ_CP023689.1\|WP_030951856.1\|7136837_7137356_-\|DUF4240-domain-containing-protein	gnl\|CDD\|379426	pfam14024, DUF4240, Protein of unknown function (DUF4240). This presumed domain is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain pfam05406.	2.90561e-51
NZ_CP023689.1\|WP_030951853.1\|7141482_7142112_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	3.46782e-33
NZ_CP023689.1\|WP_150503316.1\|7117777_7118695_-\|zinc-metalloprotease-HtpX	gnl\|CDD\|179418	PRK02391, PRK02391, heat shock protein HtpX; Provisional.	2.6075e-169
NZ_CP023689.1\|WP_125528401.1\|7122884_7123352_+\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	3.98502e-10
NZ_CP023689.1\|WP_125528402.1\|7121275_7122685_-\|type-I-glutamate--ammonia-ligase	gnl\|CDD\|273198	TIGR00653, Glutamine_synthetase, glutamine synthetase, type I. Alternate name: glutamate--ammonia ligase. This model represents the dodecameric form, which can be subdivided into 1-alpha and 1-beta forms. The phylogeny of the 1-alpha and 1-beta forms appears polyphyletic. E. coli, Synechocystis PCC6803, Aquifex aeolicus, and the crenarcheon Sulfolobus acidocaldarius have form 1-beta, while Bacillus subtilis, Thermotoga maritima, and various euryarchaea has form 1-alpha. The 1-beta dodecamer from the crenarcheon Sulfolobus acidocaldarius differs from that in E. coli in that it is not regulated by adenylylation. [Amino acid biosynthesis, Glutamate family].	0
NZ_CP023689.1\|WP_107906974.1\|7131553_7132738_-\|MarP-family-serine-protease	gnl\|CDD\|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	1.98076e-18

>NZ_CP023689.1|WP_150503320.1|7126805_7128284_+|regulator
MTERPAQRTPNRQLAALIAEAGFSNAGLARRVDQLGLEHGLDLRYDKTSVTRWLRGQQPRGTTPALIAEVFTRRLGRRLSAQDLGLDACAPVYAGLEFAATPEEAVDIVSGLWRKDSGSHAELRKIAFTPAGLVVPSRDWLIGRADDKVARGEPIARIPAQGRPVASPKFPAPLEPGGTPSRQRPQAERGPGQKVTGGDIAALRSVGELFRSLDDMYGGGHARQALVRYLEHECEPMLRGTYGEQTGRRLFAAAADLTRLAGWTSYDIAAHGLAQRYFVQALRLAQAAGDRPYGSYVLVTMSRQAVYLGHGREAVQLARVAQQGVGTSAPPVVQALLHACEARGHGVLGEVRACTASLVRAERSLEGARPGDDVPYWARFFDEAQLADEFGHCHRDLQQFRAAAQHAERSLQLRAPAYARSRLFSRVVLASARLGLGELDQACALGAEAAGAASEMRSVRAVEYVRDFERRLEPYRDAAPVRGYRDKVAALG
>NZ_CP023689.1|WP_107906970.1|7125726_7126524_-|lipoyl(octanoyl)-transferase-LipB
MSELRFVRMGFGAEAVEYQQAWDEQRRVHAARFADEISDTVLLLEHPPVYTAGRRTADNERPLDGTPVIDVDRGGKITWHGPGQLVGYPIQKLPRPVDVVAHVRRLEDALIRTCAEFGLETTRVEGRSGVWVLGDPVEQRPALGGLALDFDPRLTDEEFDPRLNGPEYAPSNAGQRREDRKIAAIGIRVAKGVTMHGFALNVNPDNKWFDRIIPCGIRDAGVASLAAELGRDVTIDEVLPVVERHLRDVLENADLKPRLIETATA
>NZ_CP023689.1|WP_030944407.1|7124656_7125622_-|lipoyl-synthase
MSAVSPDGRKMLRLEVRNSQTPIERKPEWIKTRAKMGPEYTKMQSLVKSEGLHTVCQEAGCPNIYECWEDREATFLIGGDQCTRRCDFCQIDTGKPEALDRDEPRRVGESVVTMDLNYATITGVARDDLEDGGAWLYAETVRQIHAQTAGREGGHTKVELLAPDFNAVPEQLAEVFSSRPEVFAHNVETVPRIFKRIRPGFRYERSLKVITEARDYGLVTKSNLILGMGETREEVSEALKQLHEAGCELVTITQYLRPSVRHHPVERWVKPHEFVELKDEAEQIGFSGVMSGPLVRSSYRAGRLYQMAVEKRGAYVASQAV
>NZ_CP023689.1|WP_107906968.1|7124199_7124400_-|hypothetical-protein
MQAAPVRATAIPSFTTALRAVESLLMSSGQRTARRNAWTSVLEDRRRAKDRVEAERVLEQTPAPRL
>NZ_CP023689.1|WP_150503318.1|7123450_7124152_-|DUF4191-family-protein
MARKDTAADAANPGRLKQIALTYKMTRKADKKIGLVLAAVGIVTFGVFLAIGFLIGHPIYLGILGLLLAFLATAIVFGRRAERAAFGQMEGQPGAAAAVLDDIGRGWSTTPAVAMNRSQDVVHRAVGKAGIVLVAEGNPNRVKTLLAAEKRKMNRIVADVPVHDIIVGTGEGQVELKKVRTTMLKLPRVLTGPQVTATNDRLKAMGDLMSNMPLPKGPMPKGMKLPKGGPKAR
>NZ_CP023689.1|WP_125528401.1|7122884_7123352_+|RDD-family-protein
MDKRQAIGSWLSGPRAAAEDAGVDFGYRGQQLGLPEEGPGSIARPGRRLGALVVDWGLCVLIAYGLITDGYGQATSNWALLLFFVLGVLTVGTVGFTPGKRLFGLRVVALESGTVNPLRALLRTALLCVAIPALIWDRDGRGLHDRLAQTVEVRI
>NZ_CP023689.1|WP_125528402.1|7121275_7122685_-|type-I-glutamate--ammonia-ligase
MFQNADEAKKFIADEDVKFIDVRFCDLPGVMQHFTIPATAFDPAEELAFDGSSIRGFQAIHESDMALRADLSTARVDPFRRDKTVNINFFIHDPITGEQYSRDPRNVAKKAEAYLASTGIADTAYFGPEAEFYVFDSVRFKTAENEAYYHIDSEAGAWNTGALEDNRGYKVRYKGGYFPAPPVDHFADLRAEISLELAASGLQVERQHHEVGTAGQAEINYKFNTLLAAADDLQLFKYIVKNVAWRNGKTATFMPKPIFGDNGSGMHVHQSLWTGGQPLFYDEAGYAGLSDTARYYIGGILKHAPSLLAFTNPTVNSYHRLVPGFEAPINLVYSQRNRSAAMRIPITGSNPKAKRVEFRAPDSSGNPYLAFSALLLAGLDGIKNKIEPAEPIDKDLYELAPEEHAGVAQVPTSLPAVLDRLEADHEFLLQGDVFTPDLIETWIDYKRANEIAPLQLRPHPHEFEMYFDV
>NZ_CP023689.1|WP_125528403.1|7120900_7121167_-|hypothetical-protein
MPEHEQDDHEREFDLRWADNAEHKEPSARARMLAARWKENPPEPQPFRADPDHVASRGRSSWVSTTVVLGCVVAVIVLLGYINFRAPY
>NZ_CP023689.1|WP_150506998.1|7118870_7119386_-|hypothetical-protein
MIGLAECGERADAVLLWPLLAHPVPAVRARAVAGLRLLDVVDAGRLRPLLEDPAPGVVRETGLALLPSAQELPADWLMERLGERWPRHVRVTAFRLLSAGSGIVPLRAAVELLEDPDPKLRGWAEQAVQRWHPPAGLPGGEAEVEALLDRCTHLFSSYVLRRRKWEAGVGR
>NZ_CP023689.1|WP_150503316.1|7117777_7118695_-|zinc-metalloprotease-HtpX
MQSRFRSDRQLTARMGVTLFLLGLLYVGFVAALVVLLKSWVLVVVVAAGLLGAQYWFSDRVALFGMHGRVVEREEYPALHGVVDRLCAIADMPKPVVAVSEMDMPNAFATGRNADHAVICVTTGLLRRLEPDELEGVLAHELSHVAHKDVAVITVASFLGVIAGLIVRFAFYSQLFGGGRRDQNTAAIFAMVLGVSAAVYAISFLLIRALSRYRELAADRAAALLTGRPSALASALTKVSGDIARIPTKDLRTAQAFNAFYFTPALGRDPGIAQLFSTHPRLEQRLEQLGRISAELGEAATPEGA
>NZ_CP023689.1|WP_150503324.1|7130019_7130925_-|TIGR01777-family-protein
MELSKIAVAGSSGLIGGALVRSLTADGHEVVRLVRRAPRSRDEVRWDPENGSVDTAGLAGCAAVVNLAGANVGSRRWTEEYKATLRSGRVRGTAALAQAIASLRPEERPRVFVNGSAIGYYGETGGRAVDESAPAGEGFLPSLVVDWEAAAAPAQEAGVRTVFPRTGLVVAREGGAWERLFPLFRAGLGGRMGDGRQYWSFVALHDEVAAIRHLLDTDGLSGPFNVTAPQPVTNREVTEAMGRVLRRPTLFAVPAPVLKTVLGEMAGDVLGSQRVLPARLLESGFVFAFPEIEGAIRAAAG
>NZ_CP023689.1|WP_150503326.1|7130995_7131496_+|GNAT-family-N-acetyltransferase
MPEPHQSPYIRIALPDDEEELSLLDRRTWSHLHAVTPRPQPPYSPFFDERHAPGDHLVAELDRRIVGYVRLGFPTPLASNAHVRQIQGLAVSDEARGHGVGRALIRAVVEEARRRGARRLTLRVLGHNTPARKLYESEGFVVEGVLPEEFFLEGGYVDDVIMGRTL
>NZ_CP023689.1|WP_107906974.1|7131553_7132738_-|MarP-family-serine-protease
MDLLDILLLLVILAYAASGYRRGLVAGCVSLAGFVGGAVIGVWILPWMMDLVTPGTTQATVTAVLTVLVPAVAVHELAGRLALRLRRELDRGPLRVADGVGGAVANSVAVLIVAWVAASVLAASSSPLLTSAIRDSRLLGTVQDAMPDTTPAWFSRATSALTEAGFPQVFNPFENESTAEVAKPTGDSVTAAATNAAKLSTVKIEGSSGTQGREGSGFVYSPRHVMTNAHVVAGIDEPSVRVGGVGRSYESRVVLFDPERDVAVLYVPELRAPVLKFDDEAARGDSAVVAGYPEDGDLNLQAATVANRVRATGQNIYNDDTVTREIYSIRSTVRPGNSGGPLLTTDGKVFGVVFARSTSDDETGYVLTAAEVASDARRAANATQAVDTGELVSS
>NZ_CP023689.1|WP_125530044.1|7134253_7135000_+|peptidoglycan-recognition-protein
MLVVLLACVPGLAAVLALLLCAQGVERSVAEEERPVAARPVGAYQAARPEIVPRSAWLGGDARRAQPPPRYDDKVVAVFVHHTDSPNGYDCADTPRIIRYLYAGQTGSRDWDDIGYNFLVDRCGTIYEGRAGGVDRAVTGAHTQGFNHRTAGIAALGTFTAGVPVPKAMTDAIAAIAAWKLGLSETDPRSTVPLTSSNSLSRYSRGTTADLPAIAGHNEGYMTTCPGAALSARLPDIRETAARLQGRH
>NZ_CP023689.1|WP_150503328.1|7135289_7136429_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein
MTSPYVREITREDHLSHLRLYPDASHLQIPEWGDVKPDWRAESVGWFEDGPAGEVLIASALVLYRPLPGTRRCLAYLPDGPGIDWRAPRVDRWLDALVAHVERRGAFSLRMGPPLVVRHWEADTVAAGVADPDVRHLHDLPADGLDGYALDLAERLGRFGWRRCADGNGSGFGLGQPRYGCQVPLAGRSTDELRDALAPRWQQSLATAERAGVLVSWGTAADLPEFYRLYTATAERDGFRARPLSYFQRLWAALNAVDGDRVRVYLAEYDGEVLSAALMIGVGSRVWHSYASSGRRGRELRPSSVLLWRMLGDARQAGARTYDLRSITPTLTDDRLLGRLLFKTGAGGRAVEYLGEWERPVGSQGKALQRAVGVYLGRR
>NZ_CP023689.1|WP_107907380.1|7136595_7136799_+|hypothetical-protein
MSSSNSGHGGKRVWTALCAVATVVLGPAAVTASALDQANKAPMHHAVTVERTQAYIPSDPGRRRAVA
>NZ_CP023689.1|WP_030951856.1|7136837_7137356_-|DUF4240-domain-containing-protein
MDETEFWELVDGAREGAEGDPEEQADLLVDRLLQLDPDAVLDFARHFEARYNRAYTWDLWGAAWVLLDGASDDAFDFFRCWLIGQGREVYEGGVHDPDSLADLLDDFDEEFDGDGEELGYAADEAYEQLTGTVAPDLGIPPAPPEPEGTPVDFENARVLAERFPKLWERFKD
>NZ_CP023689.1|WP_150503330.1|7137460_7138441_-|WYL-domain-containing-protein
MRAARLIKMVLLLQSRPSMTAAELARELEVSERTVTRDAQALSEAGVPVYADRGRAGGYRLIGGYRTRLTGLGRSEAEALFLSGVPGALREMGLEDTASAARLKVSAALMPSLRDASRTAAQRFHLDAPNWFKEPKTPQLLPAVADAVWDDRRIVARYRRGEAQSEAERELEPYGLVLKAGVWYLCARVAGQGSYRVYRIDRFTAVEAAGERFERDGEFDLPEFWDERAEQFARSILRSEVVVRVSPGGVRRLPYTVDPQSAREAVEAAGAPDGDGWVTLTLPVESEEVAHTQLASLGPEIEVLQPPSLRERFAGDAIRLATLYGG
>NZ_CP023689.1|WP_150503332.1|7138518_7141221_-|pyruvate-dehydrogenase-(acetyl-transferring),-homodimeric-type
MTDPNAIQPSALDQLPDRDPEETAEWQASLDAVAKAAGPHRAAYLMRRTLERAEAGGIALPKLLETDYVNTIPTAAEPTVPGDEEMERKITAWNRWNAAAMVTRGSKYGVGGHIATFASAAWLYETGFNHFFKGKEADGSGDQLYIQGHASPGIYARAFLDGRLTEAHLDNFRQEAGGNGLPSYPHPRRLPWLWEFPTVSMGLGPLSAIYQARFNRYLTARGIKDVSDSHVWAFLGDGEMDEPESTAALALASREGLDNLTFVINCNLQRLDGPVRANFKIVQELEAQFRGAGWNVVKTMWGTAWDELFQLDTTGALVRRLRQVPDAQVQTYQTRDAAYIRQDFFGADPALVEMAKLLSDDKIIECFHLSRGGHEARKVYAAYKAAVEFKGAPTVILAQTVKGHTLGAGFASKNANHQMKKLTVDEFKTMRDLLELPISDSAFADGQVPYGHPGADSAEVRYLQERRAALGGPAPARRVHPVAPLPAPAEKAFASFDKGSGSQNVATTMAFVRLIKDLVRDKESGKRWVPIVPDEARTFGMESLFPSLGIYSPKGQTYEPVDRDQLMYYKEAKNGQILNEGITEAGSMADFIAASTAYSTHGEVMIPFYIFYSMFGWQRTADQMWQLGDQLGRGFLVGATAGRTTLTGEGLQHADGHSPVIAATNPAALTYDPAFAYEVAAIVKDGLRRMYGEAAPGEDPDVFYYLTVYNEPMPQPAKPSGLGIDEGIVKGLYRFNTAESAGLSPVANAPRIQLLGSGTAIHWTLQAQKLLAEEWGVAADVWSATSWTELRRDALEADAALLRGEERVPFVRQALQGADGPVLAVSDYMRQVPDQIAQWVEQDYSSLGADGFGLSDTREAARRHFGVDAESIVVAALAQLAKRGEVKATAVKEAREKYGL
>NZ_CP023689.1|WP_030951853.1|7141482_7142112_-|GntR-family-transcriptional-regulator
MTAPVIHSLREQIREHILEGIISGRWQPGERIVERRIATELEVSQTPVREALRELESLRLIESAPNKGVRVRSLTAADLEESYPVRAGLEAIAAELAADRLAEDCSALDPHVTALYDADRNSDGTGQVRHTVAFHREMVRAAGNSVLLHTWEGLGIEVFTALSIRWLGTVQQSYAEEHEELVAAFRRRDPRIAEIVKAHVLGCAPRHES

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Crispr_ID: NZ_CP023689_17

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_17

7417972-7418060

Orphan

Consensus_repeat	Method
GGGGTGGGCGTCGAGGTCGTGGGGGTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_17

>merge|NZ_CP023689|17|7417972-7418060|CRISPRCasFinder
GGGGTGGGCGTCGAGGTCGTGGGGGTGGGCGTCGAGGTCGTGGGGTGGGTGTCGAGGTCGTGGGGTGGGTGTCGAGGTCGTGGGGGTGG

>NZ_CP023689|17|16|7417972-7418060|CRISPRCasFinder
GGGGTGGGCGTCGAGGTCGTGGGGGTGG	GCGTCGAGGTCGTGGGGTGGGTGTCGAGGTCGT
GGGGTGGGTGTCGAGGTCGTGGGGGTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150503598.1\|7419286_7419919_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|180660
NZ_CP023689.1\|WP_125529719.1\|7420522_7420960_+\|CBS-domain-containing-protein	unknown	unknown	gnl\|CDD\|341390
NZ_CP023689.1\|WP_150503607.1\|7426183_7427410_-\|formaldehyde-dehydrogenase,-glutathione-independent	unknown	unknown	gnl\|CDD\|274314
NZ_CP023689.1\|WP_107907153.1\|7425690_7426119_+\|dioxygenase	unknown	unknown	gnl\|CDD\|319916
NZ_CP023689.1\|WP_167537797.1\|7409978_7410413_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107907150.1\|7421101_7422229_-\|magnesium-and-cobalt-transport-protein-CorA	unknown	unknown	gnl\|CDD\|213364
NZ_CP023689.1\|WP_150503596.1\|7418329_7419025_-\|DUF2293-domain-containing-protein	unknown	unknown	gnl\|CDD\|370799
NZ_CP023689.1\|WP_150503594.1\|7415705_7417193_-\|glutamate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237213
NZ_CP023689.1\|WP_107907140.1\|7410403_7411042_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
NZ_CP023689.1\|WP_150503590.1\|7413434_7414916_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|224089
NZ_CP023689.1\|WP_150503603.1\|7423596_7424508_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571
NZ_CP023689.1\|WP_150503601.1\|7422628_7423423_+\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|181382
NZ_CP023689.1\|WP_125529575.1\|7412553_7413342_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|252734
NZ_CP023689.1\|WP_150503605.1\|7424681_7425590_-\|pseudouridine-5'-phosphate-glycosidase	unknown	unknown	gnl\|CDD\|377251
NZ_CP023689.1\|WP_150503592.1\|7414963_7415485_+\|carboxymuconolactone-decarboxylase-family-protein	unknown	unknown	gnl\|CDD\|225039
NZ_CP023689.1\|WP_125529574.1\|7412218_7412473_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
NZ_CP023689.1\|WP_107907141.1\|7411357_7412218_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|379262
NZ_CP023689.1\|WP_150503588.1\|7407881_7409825_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224055
NZ_CP023689.1\|WP_125529954.1\|7417369_7417849_-\|DUF1772-domain-containing-protein	unknown	unknown	gnl\|CDD\|227787
NZ_CP023689.1\|WP_150503600.1\|7419974_7420388_+\|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	unknown	unknown	gnl\|CDD\|274679

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150503598.1\|7419286_7419919_+\|uridine-kinase	gnl\|CDD\|180660	PRK06696, PRK06696, uridine kinase; Validated.	9.58524e-20
NZ_CP023689.1\|WP_125529719.1\|7420522_7420960_+\|CBS-domain-containing-protein	gnl\|CDD\|341390	cd04622, CBS_pair_HRP1_like, CBS pair domain found in Hypoxic Response Protein 1 (HRP1) -like proteinds. Mycobacterium tuberculosis adapts to cellular stresses by upregulation of the dormancy survival regulon. Hypoxic response protein 1 (HRP1) is encoded by one of the most strongly upregulated genes in the dormancy survival regulon. HRP1 is a 'CBS-domain-only protein; however unlike other CBS containing proteins it does not appear to bind AMP. The biological function of the protein remains unclear, but is thought to contribute to the modulation of the host immune response. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	1.79768e-46
NZ_CP023689.1\|WP_107907153.1\|7425690_7426119_+\|dioxygenase	gnl\|CDD\|319916	cd07253, GLOD5, Human glyoxalase domain-containing protein 5 and similar proteins. Uncharacterized subfamily of VOC family contains human glyoxalase domain-containing protein 5 and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.3338e-20
NZ_CP023689.1\|WP_150503607.1\|7426183_7427410_-\|formaldehyde-dehydrogenase,-glutathione-independent	gnl\|CDD\|274314	TIGR02819, formaldehyde_dehydrogenase_glutathione-independent, formaldehyde dehydrogenase, glutathione-independent. Members of this family represent a distinct clade within the larger family of zinc-dependent dehydrogenases of medium chain alcohols, a family that also includes the so-called glutathione-dependent formaldehyde dehydrogenase. Members of this protein family have a tightly bound NAD that can act as a true cofactor, rather than a cosubstrate in dehydrogenase reactions, in dismutase reactions for some aldehydes. The name given to this family, however, is formaldehyde dehydrogenase, glutathione-independent. [Central intermediary metabolism, One-carbon metabolism].	0
NZ_CP023689.1\|WP_107907150.1\|7421101_7422229_-\|magnesium-and-cobalt-transport-protein-CorA	gnl\|CDD\|213364	cd12830, MtCorA-like, Mycobacterium tuberculosis CorA-like subfamily. This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.	2.76117e-168
NZ_CP023689.1\|WP_150503596.1\|7418329_7419025_-\|DUF2293-domain-containing-protein	gnl\|CDD\|370799	pfam10056, DUF2293, Uncharacterized conserved protein (DUF2293). This domain, found in various hypothetical bacterial proteins, has no known function.	7.65755e-23
NZ_CP023689.1\|WP_150503594.1\|7415705_7417193_-\|glutamate-synthase-small-subunit	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
NZ_CP023689.1\|WP_107907140.1\|7410403_7411042_-\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.77864e-17
NZ_CP023689.1\|WP_150503590.1\|7413434_7414916_-\|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.61504e-110
NZ_CP023689.1\|WP_150503603.1\|7423596_7424508_-\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	7.99943e-58
NZ_CP023689.1\|WP_150503601.1\|7422628_7423423_+\|methyltransferase-domain-containing-protein	gnl\|CDD\|181382	PRK08317, PRK08317, hypothetical protein; Provisional.	9.37784e-18
NZ_CP023689.1\|WP_125529575.1\|7412553_7413342_+\|SAM-dependent-methyltransferase	gnl\|CDD\|252734	pfam04672, Methyltransf_19, S-adenosyl methyltransferase. This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure Structure 3giw suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22. The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	1.15809e-127
NZ_CP023689.1\|WP_150503605.1\|7424681_7425590_-\|pseudouridine-5'-phosphate-glycosidase	gnl\|CDD\|377251	pfam04227, Indigoidine_A, Indigoidine synthase A like protein. Indigoidine is a blue pigment synthesized by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown. The recommended name for this protein is now pseudouridine-5'-phosphate glycosidase.	9.427e-159
NZ_CP023689.1\|WP_150503592.1\|7414963_7415485_+\|carboxymuconolactone-decarboxylase-family-protein	gnl\|CDD\|225039	COG2128, COG2128, Uncharacterized conserved protein [Function unknown].	1.88489e-25
NZ_CP023689.1\|WP_125529574.1\|7412218_7412473_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	2.85018e-19
NZ_CP023689.1\|WP_107907141.1\|7411357_7412218_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	3.64668e-07
NZ_CP023689.1\|WP_150503588.1\|7407881_7409825_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.10677e-81
NZ_CP023689.1\|WP_125529954.1\|7417369_7417849_-\|DUF1772-domain-containing-protein	gnl\|CDD\|227787	COG5500, COG5500, Predicted integral membrane protein [Function unknown].	4.61716e-42
NZ_CP023689.1\|WP_150503600.1\|7419974_7420388_+\|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	4.57527e-38

>NZ_CP023689.1|WP_125529954.1|7417369_7417849_-|DUF1772-domain-containing-protein
MIDGPYFVLIVIGVVGTGLVAGVFCAFSTFVMRGLAALPPAQGVAAMKAINVTALMPAFMLVFIGTAVLCAVIAVVTFVLWPDEGTVALLLGSALYLFGSFGVTMVANVPRNDTLMKLEAGTQEAADYWPTYVREWTMWNHVRTVASAAATVSFVLAVS
>NZ_CP023689.1|WP_150503594.1|7415705_7417193_-|glutamate-synthase-small-subunit
MADPKGFMTTPRQDWPRRPVEERVGDWDEVYVPGALLPIISKQADRCMDCGVPFCHEACPLGNLIPEWNDLVSREDWRAAADRLHATNNFPEFTGRLCPAPCEAGCVLAINQPAVTIKNVECAIGDRAWEEGFAPPRPPDRLSGRTVAVIGSGPTGLAAAQQLTRAGHTVAVYEKDDRIGGLMRYGIPAFKMEKHHLERRIEQMRAEGTKFRTSTAVGRDIGAAELRSRYDAVVIATGATAWRELSVPGRELSGIEQAMEYLPLANRVCEGDLESSPMSAAGKHVVIVGGGDTGADCLGTAVREGAASVTQLDIYAQPGAERDEDAEPWPTYPKIYRLSAAHEEARDLETAPAADADARLFAASTLHFTGDADGHVRSLHLVEVDAERRHRPDTGRTLPADLVLLALGFSGPDRTDGLIEQLGLEMEPRGTITRDVGFATNVPGVFAAGDAARGQSLIVWAIAEGRAVAAAVDHHLTGSSRLPAPISPYDRPMTV
>NZ_CP023689.1|WP_150503592.1|7414963_7415485_+|carboxymuconolactone-decarboxylase-family-protein
MTTNTIENSTGIDIPGAITEAEAARTRLDFAKSAPKVFRAIVGFDAAAREGLDPALVELIQIRASLLNQCAYCLHMHTNDARKAGESEDRLHLVAVWREARHFFTEREQAALALTEAVTLVADGGVPDEAYAQAAAHFDDSELAHVLALIMTINTWNRVALATGKVAGTDERR
>NZ_CP023689.1|WP_150503590.1|7413434_7414916_-|aminotransferase-class-I/II-fold-pyridoxal-phosphate-dependent-enzyme
MTDSRVNSWVDPARRIGADLHLDLSESSGPGGRRAALTRALRDAVRSGRLAPGTRLPPYRSLAADLGVARNTVADAYAELVAEGWLSARQGSGTRVAERAEPLRRAERVPRKAPPRARGPRHDLRQGTPDASAFPRAAWLASCRRALQQAPNEVFGPGDSAGRIELREALTEYLARARGVRTEPDRIVICSGFAHALRLLFGQDRSGGGGVLRGPLAVEAYGLGFHRELLTAAGVRTVPLPLDEDGARVDRLARERAVLLTPAHQFPTGGPLHPERRTAVIDWARARGGVVLEDDYDGEFRYDRKPVGAVQGLDPERVIFIGSVSKSLSPALRLGWMVLPERYVGDLLAAKGEREAWVSVLDQLSLADFIVSGAYDRHVRRMRQRYRSRRDRLVAALAEHAPHVEVTGVAAGLHAVLRLPPGTERSTVKAATWQGVALDGLAEFRHPDAHEEDTPARDGIVVGCATPSEHAYGAALEALCGVLPPAEEPTPGE
>NZ_CP023689.1|WP_125529575.1|7412553_7413342_+|SAM-dependent-methyltransferase
MTEIDTSKPHPARMYDWYLGGKDNYPVDEAMGQQMLALDPRVPVMARVNRAFMHRSTRWLARQGVRQFLDIGTGIPTEPNLHQIAQRIAPDARVVYCDNDPIVLAHAAALLRGTEEGVTEYLQADVRDPDAIVEGARKILDFSAPVALSLVALLHFVSDEDGAHELVGRLLSELPSGSYLVMTHATADFTPEESAAATEKLKAAGVTLALRSRDEFTRFFDGLELVPPGVEVPHQWHPDLGDPVAGQEDGVIPGYGAVGRKP
>NZ_CP023689.1|WP_125529574.1|7412218_7412473_+|DUF397-domain-containing-protein
MDRIKPRISVYNGMPARDLGSEGWHKPWSGGNGGNCLEAMKLADGRIAVRQSTDPDGPALIYTTDEMTAFIEGAKAGEADFLLS
>NZ_CP023689.1|WP_107907141.1|7411357_7412218_+|helix-turn-helix-domain-containing-protein
MSEPRSAPTVGQVVLGRRLLDLRERAGLKREEAARVLRVAPATVRRMEMAEVGLKIPYLQLLLKAYGISEEEAEAFVLLAEEANKPGWWQRFHDILPGWFSMYVSLEGAAALIRSYEPHFVPGLLQTEGYARGVLKSGAIGQTSPDDIERHVALRMQRQRLLTREDAPRLWVVMDETVLRRQVGGPEVMRDQIDRLLEATKLPNVTLQVAPFANGPHPGTYGPFVLFRFAMSELPDMVYSEYLTGAVYLDARAEVATHLEVMDRMAAQAATAHRTKEILRDLRKEL
>NZ_CP023689.1|WP_107907140.1|7410403_7411042_-|ATP-binding-protein
MASVIPSPPLGTNATVVPHGLGATTGIGPQRSVGDERRFRFELAAHPGSPAQARRLTRARLNGWSVCEDTCDTAALVVSELVTNAIVHTASEHIVCELHDGTDLVRIAVRDEGCAPGEPHPSPARPEEEHGRGLLLIDALCHAWGAQEHGSGLVVWADLPRGAAFGDVPHTDNEPCSDLGWGSRPKPGPPGVPGDEDEAEARHDGGTGSAWL
>NZ_CP023689.1|WP_167537797.1|7409978_7410413_-|hypothetical-protein
MAVSGVSGGGQVLSLDSLVRLRRGMRTSAAPRRLPVPEGMTAPLGCDAVAVPARFGPLVLPRLPRVGSVYADDVHWWWILPSDSDYALEWPTGVRYSTGAVVVDTPRLIHRGDGTVPYTPPIPLYLALCRVMGTTPTWSKQITA
>NZ_CP023689.1|WP_150503588.1|7407881_7409825_-|ATP-binding-cassette-domain-containing-protein
MGKKQGAGEARVSESERLLFGGPLRYDMGWNQHRDAFLELSLRAMVTRLPSLLGSSFRLAWQADRRAARTVLAAEVGRGLAQAVGLLAVNSVLGRLIEPGELAERLRGAVPALVAMAAVMVVSTLLRAASTYATGRLEPKVERVATELYLERAAAVELSAIEDHAFHKLLDTAQYGAASARRMISYSARVVNAGISLIAAAGVLAVLHPALLPLLATMTLPSAWSALTNARRRYESFHTWVQHARAGHLISGLLTEPAAAPEIRVHGVGPFLLRHYRAMSETAEAEQARLARLAARTGLIAAAWTGLATVATYATLGGLLLAGAMALSVAGTAVIAIRTGSSSLDSLVLEVNALHEEALFVGDLQRLYVEAAERAIPVGGAALPVDPREIRFENVSFSYPGESARPALDDVTLTLPLGRIVALVGENGSGKTTLVKLLAGLYTPDRGRVLWDDVDAAGADRHQLAERIAMVAQDFKRWPFTARVNVAVGRSSAPLTEERLATSVAEAGAEEVVADLPRGLDTLLARQFNGGHELSGGQWQRLGIARAAYRRGRILIVDEPTAALDARAELEVFEKIRALASTGQTVVLITHRLASVRHADLVHVLDQGRLVESGTPDELLATGGVYAELYSLQAEQFTTRVPAPKAS
>NZ_CP023689.1|WP_150503596.1|7418329_7419025_-|DUF2293-domain-containing-protein
MAPLATPPHRTGLLVVQPLKRRHCGECQAGPLQMLVLEDGAPRCLDCADLGHLVFLPRGDTALTRRSREESALSAVVVRFNRRRSRYERQGVLVEEAALARAEERCLADAEARRRRRMRDARRRAREDVRFAEAFGAEIRRLFPGCPADRARDIAGHASVRGSGRVGRSAAGRALTEVAVTSAVVAAVRHTDTPYDQLLMSGVPRHEARRRIMAMVETTLRAWRAGVSEAG
>NZ_CP023689.1|WP_150503598.1|7419286_7419919_+|uridine-kinase
MRLEAITWDRLGEHLAERLLDLEPADGSPWPRVAFDGAPAARPGDLAERVGEALRIRGRPSLTVGTEGFLRPASVRLEYGHRDIEAYYDGWVDTGALWREVFGPLEPGGDGRVLPDLWDPAIDRATRSPHVQLPPGGILLMHGPLLLRHWFPFDLTVHVLLSPGALRRRTPETEHWTLPAFDRYGHETDPANAADVLVRADDPRHPAWSG
>NZ_CP023689.1|WP_150503600.1|7419974_7420388_+|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase
MTTSASDPVPFDDSVRTLLDGKNFASVATLGPDGAPQNSVVWIKREGDTVLFSSVDARQKVRNLRRDPRISVSVYDLANPYSSVEIRGVAEIVPDEAKRLPFELSHKYLGIEPPAEKDDETRVIIRVVPRKLVRFSA
>NZ_CP023689.1|WP_125529719.1|7420522_7420960_+|CBS-domain-containing-protein
MTTAGDIMHRGAQWIPTHETLDRAAQLMRELGVGALPISDENERLCGILTDRDIVIGCVAMGHDPSKVTAGEMAQGTPRWIDASADISDVLREMKDHQIRRLPVIEDKRLVGMISEADLARSLPEDEIGPWAESVYAMSAAPRTH
>NZ_CP023689.1|WP_107907150.1|7421101_7422229_-|magnesium-and-cobalt-transport-protein-CorA
MSMAGNLRKVTGLDRVGGLRKVARLARRRPRVDLSHPARSPLGSSVVNCVAYRDGARIPETGDLVDVVQRVRKRGGGFVWLGLHEPTDGEFAGIAELFDLHPLAVEDAVEAHQRPKLERYDETLFAVFKTVCYVEHEQLTATSEVVNTGEIMVFVGRDFVITVRHGRHGSLGPLREELESDPEQLAKGPAAVLHAIADHVVDDYLSVTDSVQEDIDEVETDVFAENGARADPGRIYQLKRELLELKRAVVPLSRPLEELATGPIRVVEPEIQAYFRDVSDHLLRAKEQIFAFDELLNSILQAHLAQVTVAQNEDMRKITAWAAIIAIPTMVCGVYGMNFDYMPELRWTFGYPLVIGVISVACVVLYRGFRRNGWL
>NZ_CP023689.1|WP_150503601.1|7422628_7423423_+|methyltransferase-domain-containing-protein
MTRNDGYLLDNRQTEAGERFDAFATLFDPTTFRHIEGFGIGAGWRCWEVGAGGTSVVSWLAKKVGPTGKIVATDIDTSQLASDARPPVEVRVHDVSADEPPGEGFDLVHARLVLVHVPDRERALRSMIESLRPGGRLLIEDADPALQPLICPDEYGPEQQLANRLRQGFRKLLADRGADLSYGRRLPRLLREAGLRQVTADAYFPITSPACAALESATVRQVRDQLVTGGIATDADIDRHLANVASGRMDLATAPLISAWGRKP
>NZ_CP023689.1|WP_150503603.1|7423596_7424508_-|sugar-kinase
MSARDGALLVVGDVVTDVIARHQGPVASGTDTAAAIRTVPGGAGANVACWAAYGGGREVRLLGRVGTDAVEWHERELTASGVRPCLVVDPQAPTGTVICLVDTGAAAERTFLTDSGASLRLEPRDWSDALLDGVAWLHLSGYLLFSAPSRALVTAAIASARARGVPVSLDPASAGFLVELGVDRFLALVEGVDVLLPSRDEACLLTGLPDAADAAAKLSRHVPMVVAKQGADGALVARSGTVTAHVPAVPATPRDTTGAGDAFTGAFLAALLTGAAPEEAAGEGCRAGAMAVERVGGRPPRVG
>NZ_CP023689.1|WP_150503605.1|7424681_7425590_-|pseudouridine-5'-phosphate-glycosidase
MVLVVSEEVREAIDARRPVVALESTIIAHGLPRPRNLQVALELEDVVRREGAVPATIAVLDGRPHVGLDKDQLERVANEDGIRKLGHRDLPLAVAAGASGATTVSATALLAALAGVRVFATGGLGGVHREWTVTQDESADLGLLARTRITVVCAGVKSILDVPATLQRLETLGVAVAGYRTDHFPGFYLSDSGHPVDWTLRSPEEAAEVMRAQDGLDEPESALIVANPVPEAEQLDPELHARVLADALHACEEQGVTGQAVTPFLLDYLVRHTDGASLSANLAAVRGNVRLAGRIAAAWAGA
>NZ_CP023689.1|WP_107907153.1|7425690_7426119_+|dioxygenase
MKDHIARLDHVVLWVRDPEASADFFEKAVGMEPVRLSEFSAGAVPFPSVRLNEETILDLMPLTMAERMKMLPGSAESSGHPVNHVCVALPGDEFDALRARLEEHGAPVSDIARDSFGARGKAKRSFYFRDPDGNVFEARHYD
>NZ_CP023689.1|WP_150503607.1|7426183_7427410_-|formaldehyde-dehydrogenase,-glutathione-independent
MSGNRAVAYLKPGTVEVRTIDYPTLELQDGPGVARDNIGRKCRHGVILKVLASNICGSDQHMVRGRTTAPEGLVLGHEITGEVVERGPDVETIDVGDIVSVPFNIACGRCRNCKERKTGICLNVNPARPGAAYGYVDMGGWVGGQAEFAMIPYADFNLLKFPDRDQARAKLLDLTMLSDIFPTGFHGVVTSGAGVGSTVYVAGAGPVGLAAAASAHLLGAAVVIVGDLNAERLAQARSFGCETVDVSQGDVGEQIAQILGEPEVDAAVDAVGFEARGHGRNAEEAPATVLNSLMGITRAGGALGIPGLYVTADPGGIDEDAKSGTLKVRLGLGWAKSHRFTTGQCPVMQYHRGLMMAILHERVQIAKAVNATVIGIEEAPRGYAEFDQGASRKYVLNPHGALDGLRPV

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Crispr_ID: NZ_CP023689_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_18

7680383-7680496

Orphan

Consensus_repeat	Method
CGGCCGAGTGGGCCGCGTCGGGACGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP023689_18

>merge|NZ_CP023689|18|7680383-7680496|CRISPRCasFinder
CGGCCGAGTGGGCCGCGTCGGGACGACCGGGATCGTGACCGTGGGTTCCGTCGGGACGGCGACCGTCCGTCCTTCCGTCGTGACGACCGGCCGAGTGGACCGCGTCGGGACGAC

>NZ_CP023689|18|17|7680383-7680496|CRISPRCasFinder
CGGCCGAGTGGGCCGCGTCGGGACGAC	CGGGATCGTGACCGTGGGTTCCGTCGGGACGGCGACCGTCCGTCCTTCCGTCGTGACGAC
CGGCCGAGTGGACCGCGTCGGGACGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_107907324.1\|7672698_7673481_-\|sporulation-protein	unknown	unknown	gnl\|CDD\|369195
NZ_CP023689.1\|WP_107909118.1\|7683340_7684369_+\|HAD-hydrolase-like-protein	unknown	unknown	gnl\|CDD\|319832
NZ_CP023689.1\|WP_107907325.1\|7673620_7674271_+\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|376746
NZ_CP023689.1\|WP_150507035.1\|7690167_7691886_+\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
NZ_CP023689.1\|WP_150503827.1\|7667971_7668760_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_125528127.1\|7672115_7672655_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NZ_CP023689.1\|WP_107907320.1\|7669797_7670229_+\|NfeD-family-protein	unknown	unknown	gnl\|CDD\|224501
NZ_CP023689.1\|WP_150503834.1\|7686578_7687538_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224045
NZ_CP023689.1\|WP_125528125.1\|7666805_7667447_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|225107
NZ_CP023689.1\|WP_107909122.1\|7687521_7687869_-\|sterol-binding-protein	unknown	unknown	gnl\|CDD\|379708
NZ_CP023689.1\|WP_150503830.1\|7681975_7683268_-\|DUF1015-family-protein	unknown	unknown	gnl\|CDD\|377633
NZ_CP023689.1\|WP_030953703.1\|7668906_7669704_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
NZ_CP023689.1\|WP_125526988.1\|7689051_7689957_+\|NAD-kinase	unknown	unknown	gnl\|CDD\|235121
NZ_CP023689.1\|WP_150507033.1\|7685535_7686582_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|227119
NZ_CP023689.1\|WP_030951938.1\|7667615_7667861_+\|chaplin	unknown	unknown	gnl\|CDD\|367652
NZ_CP023689.1\|WP_125526990.1\|7687911_7688232_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107909124.1\|7688239_7689055_+\|TlyA-family-RNA-methyltransferase	unknown	unknown	gnl\|CDD\|224110
NZ_CP023689.1\|WP_150503832.1\|7684447_7685491_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	unknown	unknown	gnl\|CDD\|182464
NZ_CP023689.1\|WP_107907322.1\|7671463_7671970_-\|HNH-endonuclease	unknown	unknown	gnl\|CDD\|224321
NZ_CP023689.1\|WP_107907321.1\|7670374_7671331_+\|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl\|CDD\|223407

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_107907324.1\|7672698_7673481_-\|sporulation-protein	gnl\|CDD\|369195	pfam07070, Spo0M, SpoOM protein. This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH.	4.69709e-109
NZ_CP023689.1\|WP_107909118.1\|7683340_7684369_+\|HAD-hydrolase-like-protein	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.21733e-100
NZ_CP023689.1\|WP_107907325.1\|7673620_7674271_+\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|376746	pfam02245, Pur_DNA_glyco, Methylpurine-DNA glycosylase (MPG). Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.	8.21744e-89
NZ_CP023689.1\|WP_150507035.1\|7690167_7691886_+\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	5.51122e-180
NZ_CP023689.1\|WP_125528127.1\|7672115_7672655_-\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	2.77895e-60
NZ_CP023689.1\|WP_107907320.1\|7669797_7670229_+\|NfeD-family-protein	gnl\|CDD\|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	1.21115e-15
NZ_CP023689.1\|WP_150503834.1\|7686578_7687538_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	7.72614e-135
NZ_CP023689.1\|WP_125528125.1\|7666805_7667447_+\|response-regulator-transcription-factor	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.95094e-81
NZ_CP023689.1\|WP_107909122.1\|7687521_7687869_-\|sterol-binding-protein	gnl\|CDD\|379708	pfam14864, Alkyl_sulf_C, Alkyl sulfatase C-terminal. This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates.	2.15684e-05
NZ_CP023689.1\|WP_150503830.1\|7681975_7683268_-\|DUF1015-family-protein	gnl\|CDD\|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	6.34316e-123
NZ_CP023689.1\|WP_030953703.1\|7668906_7669704_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	8.6982e-93
NZ_CP023689.1\|WP_125526988.1\|7689051_7689957_+\|NAD-kinase	gnl\|CDD\|235121	PRK03372, ppnK, inorganic polyphosphate/ATP-NAD kinase; Provisional.	4.94974e-174
NZ_CP023689.1\|WP_150507033.1\|7685535_7686582_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|227119	COG4779, FepG, ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism].	3.74762e-106
NZ_CP023689.1\|WP_030951938.1\|7667615_7667861_+\|chaplin	gnl\|CDD\|367652	pfam03777, DUF320, Small secreted domain (DUF320). Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	1.41929e-17
NZ_CP023689.1\|WP_107909124.1\|7688239_7689055_+\|TlyA-family-RNA-methyltransferase	gnl\|CDD\|224110	COG1189, COG1189, Predicted rRNA methylase [Translation, ribosomal structure and biogenesis].	5.4953e-101
NZ_CP023689.1\|WP_150503832.1\|7684447_7685491_+\|iron-chelate-uptake-ABC-transporter-family-permease-subunit	gnl\|CDD\|182464	PRK10441, PRK10441, Fe(3+)-siderophore ABC transporter permease.	6.37087e-93
NZ_CP023689.1\|WP_107907322.1\|7671463_7671970_-\|HNH-endonuclease	gnl\|CDD\|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	1.41226e-17
NZ_CP023689.1\|WP_107907321.1\|7670374_7671331_+\|SPFH/Band-7/PHB-domain-protein	gnl\|CDD\|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	2.66187e-68

>NZ_CP023689.1|WP_107907325.1|7673620_7674271_+|DNA-3-methyladenine-glycosylase
MIATPDRTPLPRDFFDRPVLEVAPDLLGRILVRTTPDGPIALRLTEVEAYDGPNDPGSHAYRGPTPRNGVMFGPPGYVYVYFTYGMWHCMNLVCGPEGRASAVLLRAGEIVEGAELTRKRRLSARNDKELAKGPARLATALDVDRALDGTDACASGETPLRILAGTPVPSDQVRNGPRTGVAGDGGNGDVHPWRYWIANDPTVSPYRAHVPKRRSS
>NZ_CP023689.1|WP_107907324.1|7672698_7673481_-|sporulation-protein
MAFKKLLASLGAGGASVETVLTEVNVVPGGVVQGEVRIQGGSVSQNIEGLSVGLQARVEVETQDSEYKQDIEFTKMQLGGAFELQPGAVHAVPFGLEIPWETPVTMIDGQSLRGMNIGVSTELAIARAVDSTDLDPINVHPLPAQKAILDAFIQLGFRFKNADMERGHIRNTRQKLPFYQEIEFFPPQQYRGINQVELSFVADGNAMDVVLEMDKKPGLFSEGSDTFRSFQVGLNDFHGTDWAAYLNQWLSEVGSKRNWF
>NZ_CP023689.1|WP_125528127.1|7672115_7672655_-|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MTELKRRPLPHDFHPPVPSFTVTSEDVEAGGTLKDAQVQAAGNTSPQLRWEGFPAGTKSFAVTCYDPDAPTGSGFWHWVLFDIPASVTELPAGAGSGKFEGLPEGAVQARNDAGSKDFTGAAPPPGDGPHRYVFTVYAVDQEKLGPDSTASPAAVGFNLRFHTLARAHVIAEYEVPAES
>NZ_CP023689.1|WP_107907322.1|7671463_7671970_-|HNH-endonuclease
MRDTLVLNASFEPLSTVTLNRAVVLVLQDKAVVEQAHPELRMRGAEVDIPAPRVIRLCRYVRVPFRRQAPWSRRGVLVRDRHRCAYCGRRATTVDHVVPRSHGGQDTWLNTVASCAEDNHRKADRTPEQAGMPLLREPFEPTPADAMLLTLGAEEFAALPDWLATDAA
>NZ_CP023689.1|WP_107907321.1|7670374_7671331_+|SPFH/Band-7/PHB-domain-protein
MEPVIIVLIILVVLVFIALIKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDTIRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILTAEGTRQAAILTAEGEKQSQILRAEGEAKAAALRAEGEAQAVRTVFEAIHAGDPDQKLLSYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLSGAMGNLGGLGGGSGNGGSPGIPGQATERREKPSID
>NZ_CP023689.1|WP_107907320.1|7669797_7670229_+|NfeD-family-protein
MEIDAWVWWLIGAAALGIGLVITAMPELGMLAVGAVAAAVAAGIFGGDAVVQVVAFVVVSTALIAVVRPIANRHRAQRPQLATGIEALKGKQAVVLERVDASGGRIKLAGEIWSARALDTDRAYEAGQEVDVVDIEGATAIVM
>NZ_CP023689.1|WP_030953703.1|7668906_7669704_+|ABC-transporter-ATP-binding-protein
MSDVLELQDVSVVREGRALVDQVSWSVKEGERWVILGPNGAGKTTLLNVASSYLYPSKGTATILGETLGTPGTDVFELRPRIGVAGIALAEKLPKRQTVLQTVLTAAYGMTATWNEDYEDVDEQRARAFLDRLGMSDYLDRKFGTLSEGERKRTLISRALMADPELLLLDEPAAGLDLGGREDLVRRLGRLARDPIAPSMLMVTHHVEEIPPGFTHVLMIRQGKVLAAGPMELELTSRNLSLCFGLPLVVEQVGDRWTAQGLPLS
>NZ_CP023689.1|WP_150503827.1|7667971_7668760_-|hypothetical-protein
MLSEPRSGRLAAWGNALLAGLVSPDDAVHEIVGDDAVHRVEGLPGESAPVGLTLGLGRLRALGVSGLRIALPAPGHPLGLSGPPEFNARAMDAEEAVICHGAAFGLVPEVSEAGPDGDVHVEVVWRVLPVREAPPADVPSLGEAERELAEGLREATEVLSRLDVAGSGPVAEAAIDAYRARAERGREVLAPGYPPRAVRVLELAQRVGLLVSLARENGHGGAVSSAEMGARTEALRPVERVARRAQVAAYNAYVEERERGAR
>NZ_CP023689.1|WP_030951938.1|7667615_7667861_+|chaplin
MKNLKKAAAVTMVAGGLLAAGAGMASATDGAHADGQAVGSPGVASGNLVQAPVHIPVNVSGNSVNVVGILNPAFGNLAVNK
>NZ_CP023689.1|WP_125528125.1|7666805_7667447_+|response-regulator-transcription-factor
MADAIKVLLVDDHQVVRRGLRTFLEVQDDIEVVGEAADGAEGVARAEELKPDVVLMDVKMPGMDGVDALRKLRELDNPARVLIVTSFTEQRTVIPALRAGAAGYVYKDVDPDALAGAIRSVHAGHILLQPEVAGALLSQEEANSGQGRGGSLTEREREVLGLIADGRSNREIARALVLSEKTVKTHVSNILMKLDLADRTQAALWAVRHGVTG
>NZ_CP023689.1|WP_150503830.1|7681975_7683268_-|DUF1015-family-protein
MNTAGHPEATARRGLELTPFRGLRYDPDRVGSLAAVTSPPYDVVVRPDGLHHLQDSDPHNIVRLILPQADTPAARNEQAARTLHRWLSEGVLTTDTDPGLYVYEQRDGAGMLQRGVIGALRVSEPSEGLVLPHEDVMPHVVADRADLMRATSANLEPLLLTYRGNGTAADTSSVIERTIEGPPLLATTTEDGFSHRLWSITDPADLDRIQSDLARRQALIADGHHRWATYRRLRAEHGSPSAWDYGLVLLVDTARYPLRVRAIHRLLHGVPVPDALAALDGLFHVRRLEVPLAAALETLADAACAGNAFLIAGDGAFHLVDQPDADLLARTVPADRPTAWRTLDATVLHATLLAHVWHVPEDDPTRIAYIHDTAATVAKAERDGGTAVLMHPVREDVVRDLARQGVTMPRKSTSFGPKPASGLVLRALDL
>NZ_CP023689.1|WP_107909118.1|7683340_7684369_+|HAD-hydrolase-like-protein
MSQSVRTSPSGSGRALSEAYDTALLDLDGVVYAGGNAIVHAVESLAAARTGGMHLAYVTNNALRTPDVVAAHLTALGIPTGADDVITSAQAAARLISEQVPEGARVLVIGGEGLRVALRERGLEPVESADDDPAAVVQGFGGPELVWGRFAEACYAIARGVPWFASNTDLTIPGARGIGPGNGAAVEVVRIATGAEPQVAGKPLPPMHRETILRTGAERPLVVGDRLDTDIEGAFNGEVDSLLVLTGVTDGAQLLAAPPQHRPTYVDADLRGLLTGQPEVAGQGEGFRCGGWTATARADRLELDGDGTPLDGLRALCAAAWTAAGDGSYALDSGKVLARLGW
>NZ_CP023689.1|WP_150503832.1|7684447_7685491_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MLVDSPPEQRAESVSAPPTRRATRAVGLLVSVLILLAVVLASIAIGAKQLSLGEVWHGLFESSGTYGDVVVGDRISRTVLGLLAGAALGLAGAVLQALTRNPLADPGLLGINAGASAAVVTAITFFGITSLSVYVWFAFLGAAAVGAMVWFLGGSRGATPVRLALAGTAISAALYGYLQAVMIMDSAALNRMRFWTVGSLTSATDSTIKQVLPFLVAGMVLALALARPLNAMEMGDDTAKALGANLNRTRVLSMLAATVLCGAATAACGPIVFVGLMVPHVVRSFTGPDLRWILPYAAVLSPVLLLGADIIGRIVARPSELQVGIVTAILGGPVFIFLVRRRRTAQL
>NZ_CP023689.1|WP_150507033.1|7685535_7686582_+|iron-chelate-uptake-ABC-transporter-family-permease-subunit
MKSTRANRAVRTPGGLSVRLDVRALTVVLLLLLAGLAASVLLIGTGDFPIGAGDVLRTLFGGGDAGQEFIVNELRLPRVLVGLLVGASLGLGGALFQALSRNPLGSPDILGLGQGATAGALVVIVLFSGDAGQVTVGALVGGLATGLAIYLLAWKRGVHGYRLVLVGIGMSAIMTAVNGYLLTKADLVDAARAVVWMTGSLSGRDWAQVWPLLALCGLLVPLVLANARGLRMMEMGDDVSYALGVRVERVRLLLMLAAVLLTAAATAAAGPVSFVALTAPQLARRLTRSPGPNLLPSLCMGAALLVAADWISQRVFGADQMPVGVVTGVLGGVYLLWLLVTERKAGRI
>NZ_CP023689.1|WP_150503834.1|7686578_7687538_+|ATP-binding-cassette-domain-containing-protein
MSAGDNKSSKSSHGLSSGPNHRRSTVNRLSADNVTLAYDQRVIAEQLSVEIPDNSFTVIVGPNACGKSTLLRALSRMLKPSQGRVLLDGQVIQSMPAKKVARTLGLLPQSSIAPDGITVADLVGRGRYPHQGILRQWSTEDERVVQESMEQTGVAELADRYVDELSGGQRQRVWIAMALAQQTPLLLLDEPTTYLDIQHQIDVLDLCAQLHEEQGRTLVAVLHDLNHAARYATHLIALRGGAVIAEGAPNDIVTAELVEEVFGLRCQVIDDPETGTPLVVPAARKAREQVKKEQGTKDRAEREAAEVAQGDKVAATEAS
>NZ_CP023689.1|WP_107909122.1|7687521_7687869_-|sterol-binding-protein
MATTEECRAALEKLSDNMQRAEGDARSAAALDRSVSCHITDLDVTFAGRMAGGRIHVHDTLQGPPREKAQIRLSMTGDDLVALVAGELNFAKAWGAGRVKLHAGMRDLLLLRKLL
>NZ_CP023689.1|WP_125526990.1|7687911_7688232_+|hypothetical-protein
MSDTVPETQIPVAQAEAETAAEDATGLAAEPEYDPAAPAPLNVPRVPTGDAEVDARLERLGDADHLATDGHLEVYEDVHRGLRDALTALDARPGPPAPPSMPGMRS
>NZ_CP023689.1|WP_107909124.1|7688239_7689055_+|TlyA-family-RNA-methyltransferase
MAGVARRRLDAELVRRKLARSREHASQLIAAGRVTVGKTVATKPATQVETAAAIVVQADSGDPEYVSRGGHKLAGALEVFVPRGLEVRGRRALDAGASTGGFTDVLLRAGAAHVVAVDVGYGQLAWTLQSDERVTVKDRTNVRELTLEAIDGEPVDLVVGDLSFIPLGLVLPALVRCVKPDADLVMMVKPQFEVGKERLGSGGVVRSPQLRAEAVRGVAEKAWDLGLGVNGVTASPLPGPSGNVEYFLWLRAGAPALDPADVDRAVAEGPR
>NZ_CP023689.1|WP_125526988.1|7689051_7689957_+|NAD-kinase
MMQNSARTVFLLAHTGRPAAIRSAELVVKGLLRSGIGVRVLSAEAQDLPLPDEVELVKEATPQCLDGCELLIVLGGDGTLLRGAEFARASGVPMLGVNLGRVGFLAEAERDDLDKVVDRVVTKAYEVEERMTVDVVVHKNGDIVHTDWALNEAAVQKAGAEKLLEVVLEIDGRPVTGFGCDGIVLSTPTGSTAYAFSAGGPVVWPEVEALLMVPISAHALFAKPLVTSPDSVLAVEVLPHIPPGVLWCDGRRTVELPPGARVEVRRGAVPVRLARLHHASFTDRLVAKFALPVSGWRGAPH
>NZ_CP023689.1|WP_150507035.1|7690167_7691886_+|DNA-repair-protein-RecN
MRIRSLGVIDDAVVELSPGFTAVTGETGAGKTMVVTSLGLLLGGRADPALVRIGAEKAVVEGRITVPAGTSAVVRAEEAGAELDDGALLISRTVSAEGRSRAHLGGRSVPVGMLAELADELVAVHGQTDQQGLLKLTRQRQALDRYAGDAVAVPLAKYGEAYRRLRAVAVELEEIVTRARERAQEADMLRFGLDEIAGVEPRAGEDVELAEEAERLGHAEALSSAATAAHAALAGNPEDPEGIDAATLVAGAQRALDAVRAHDPALAALADRIGEIGILLGDVAGELAGYADDLDADPLRLAAVEERRAALNTLTRKYGEDIATVLAWAEQGSSRLTELDSDDDRIGELTAERDGLRAELGGLAQALTDARTEAAERFAAAVTAELASLAMPHARVSFALRQTEDPEGVEVDGRTVAYGPSGVDEVELLLAPHPGAPPRPIAKGASGGELSRVMLAVEVVFAGTDPVPTYLFDEVDAGVGGKAAVEIGRRLARLAKTAQVVVVTHLPQVAAFADRQLLVEKTNDGTVTRSGVKVLEGEERVRELSRMLAGQEDSETARAHAEELLETARSDG

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Crispr_ID: NZ_CP023689_19

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP023689_19

7745499-7745600

Orphan

Consensus_repeat	Method
TAGGGGCGCGGGGAACTGCGCAA	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of NZ_CP023689_19

>merge|NZ_CP023689|19|7745499-7745600|CRISPRCasFinder
TAGGGGCGCGGGGAACTGCGCAACGGTTGTGACGGGTGCGGTCACGTCGCGGCGCAGGCCCACTGCAACGCCCTTCTTTTAGGGGCGCGGGGAACTGCGCGA

>NZ_CP023689|19|18|7745499-7745600|CRISPRCasFinder
TAGGGGCGCGGGGAACTGCGCAA	CGGTTGTGACGGGTGCGGTCACGTCGCGGCGCAGGCCCACTGCAACGCCCTTCTTT
TAGGGGCGCGGGGAACTGCGCGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP023689.1\|WP_150503894.1\|7752387_7753260_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|224001
NZ_CP023689.1\|WP_150503900.1\|7755714_7756164_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
NZ_CP023689.1\|WP_150507039.1\|7740283_7741501_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368211
NZ_CP023689.1\|WP_107909165.1\|7744155_7745238_+\|S1-family-peptidase	unknown	unknown	gnl\|CDD\|365866
NZ_CP023689.1\|WP_150503879.1\|7731654_7732695_+\|WYL-domain-containing-protein	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
NZ_CP023689.1\|WP_150503898.1\|7754629_7755529_-\|DUF4436-family-protein	unknown	unknown	gnl\|CDD\|379624
NZ_CP023689.1\|WP_107909163.1\|7741907_7742813_+\|S1-family-peptidase	unknown	unknown	gnl\|CDD\|365866
NZ_CP023689.1\|WP_150503896.1\|7753363_7754401_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|376983
NZ_CP023689.1\|WP_125527906.1\|7738228_7739419_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173840
NZ_CP023689.1\|WP_107909159.1\|7734728_7734944_+\|proteinase-inhibitor-I78	unknown	unknown	gnl\|CDD\|288556
NZ_CP023689.1\|WP_150503890.1\|7751279_7751654_-\|cupin-domain-containing-protein	unknown	unknown	gnl\|CDD\|380433
NZ_CP023689.1\|WP_150503883.1\|7736497_7738105_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|184957
NZ_CP023689.1\|WP_150503887.1\|7746851_7750298_+\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
NZ_CP023689.1\|WP_093745465.1\|7756191_7756332_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP023689.1\|WP_107909164.1\|7742977_7743877_+\|slipin-family-protein	unknown	unknown	gnl\|CDD\|259808
NZ_CP023689.1\|WP_030954768.1\|7739454_7739892_-\|cell-division-protein-SepF	unknown	unknown	gnl\|CDD\|377370
NZ_CP023689.1\|WP_150503892.1\|7751767_7752214_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
NZ_CP023689.1\|WP_150503888.1\|7750294_7751263_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176459
NZ_CP023689.1\|WP_150503881.1\|7735034_7736063_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
NZ_CP023689.1\|WP_150503885.1\|7745607_7746687_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|274414

Protein	Function_ID	Function_description	E-value
NZ_CP023689.1\|WP_150503894.1\|7752387_7753260_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	1.10505e-26
NZ_CP023689.1\|WP_150503900.1\|7755714_7756164_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	2.31907e-09
NZ_CP023689.1\|WP_150507039.1\|7740283_7741501_+\|hypothetical-protein	gnl\|CDD\|368211	pfam04959, ARS2, Arsenite-resistance protein 2. Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.	7.63179e-07
NZ_CP023689.1\|WP_107909165.1\|7744155_7745238_+\|S1-family-peptidase	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	2.21295e-12
NZ_CP023689.1\|WP_150503879.1\|7731654_7732695_+\|WYL-domain-containing-protein	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	1.58565e-54
NZ_CP023689.1\|WP_150503898.1\|7754629_7755529_-\|DUF4436-family-protein	gnl\|CDD\|379624	pfam14494, DUF4436, Domain of unknown function (DUF4436). This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.	9.70367e-57
NZ_CP023689.1\|WP_107909163.1\|7741907_7742813_+\|S1-family-peptidase	gnl\|CDD\|365866	pfam00089, Trypsin, Trypsin.	5.33826e-12
NZ_CP023689.1\|WP_150503896.1\|7753363_7754401_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|376983	pfam03067, LPMO_10, Lytic polysaccharide mono-oxygenase, cellulose-degrading. This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.	1.13701e-64
NZ_CP023689.1\|WP_125527906.1\|7738228_7739419_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
NZ_CP023689.1\|WP_107909159.1\|7734728_7734944_+\|proteinase-inhibitor-I78	gnl\|CDD\|288556	pfam11720, Inhibitor_I78, Peptidase inhibitor I78 family. This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78.	0.00210495
NZ_CP023689.1\|WP_150503890.1\|7751279_7751654_-\|cupin-domain-containing-protein	gnl\|CDD\|380433	cd20299, cupin_YP766765-like, Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain. This family includes mostly bacterial proteins homologous to Rhizobium leguminosarum YP_766765.1, a protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.28822e-24
NZ_CP023689.1\|WP_150503883.1\|7736497_7738105_+\|MFS-transporter	gnl\|CDD\|184957	PRK14995, PRK14995, SmvA family efflux MFS transporter.	1.25355e-109
NZ_CP023689.1\|WP_150503887.1\|7746851_7750298_+\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
NZ_CP023689.1\|WP_107909164.1\|7742977_7743877_+\|slipin-family-protein	gnl\|CDD\|259808	cd08826, SPFH_eoslipins_u1, Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes a subgroup of the stomatin-like protein family (SLPs or slipins) that is found in bacteria and archaebacteria. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Bacterial and archaebacterial SLPs remain uncharacterized. This subgroup contains PH1511 from the hyperthermophilic archaeon Pyrococcus horikoshi.	3.96906e-90
NZ_CP023689.1\|WP_030954768.1\|7739454_7739892_-\|cell-division-protein-SepF	gnl\|CDD\|377370	pfam04472, SepF, Cell division protein SepF. SepF accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation. Mutants are viable but the formation of the septum is much slower and occurs with a very abnormal morphology. This family also includes archaeal related proteins of unknown function.	7.45649e-27
NZ_CP023689.1\|WP_150503892.1\|7751767_7752214_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	5.64428e-15
NZ_CP023689.1\|WP_150503888.1\|7750294_7751263_+\|hypothetical-protein	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	7.89223e-49
NZ_CP023689.1\|WP_150503881.1\|7735034_7736063_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	7.01077e-31
NZ_CP023689.1\|WP_150503885.1\|7745607_7746687_-\|ABC-transporter-permease	gnl\|CDD\|274414	TIGR03062, hypothetical_protein_lp_1332, YhgE/Pip C-terminal domain. This family contains the C-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03061, represents the conserved N-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.	1.81866e-12

>NZ_CP023689.1|WP_107909165.1|7744155_7745238_+|S1-family-peptidase
MKHRRIPKRRAAVAGAGIAALVAAGVTLQTANASETPETSAPKTLSVSAAGKLASTLVKDLGGDAAGSYYDTQAKSLVVNVLDEAAADAVEAAGAKARVVENSLAELKSARTTLKQDATIPGTAWVTDPATNRVVVTADRTVSDAEWAKLGKVVDGLGAKAELKRSKGEYKPFIAGGDAITGGSGRCSLGFNVVKGGEPFFLTAGHCTESIKDWSDSSGTQIGSNESSSFPDNDYGLVKYTAEVEHPSEVNLYNGSTQAISGAAEATVGMEVTRSGSTTQVHDGKVTGLDATVNYGNGDIVNGLIQTDVCAEPGDSGGSLFSGDKAIGLTSGGSGDCTAGGETFFQPVTEALSATGTEIG
>NZ_CP023689.1|WP_107909164.1|7742977_7743877_+|slipin-family-protein
MVEELVAAGVTLASAGLVYVAAAARVVKQYERGVVFRLGKLRPEVRGPGFTMIVPGVDKLRKVNMQIVTMPIPAQEGITRDNVTVRVDAVVYFKVTAPAEAVVRVEDYRFAVSQMAQTSLRSIIGKSELDDLLSSRERLNQGLELMIDSPAVEWGVTIDRVEIKDVSLPETMKRSMARQAEADRERRARVINADAELQASKKLAEAAHQMSDAPAALQLRLLQTVMAVAAEKNSTLVLPIPVELLRFLEKGAQVAVPGQGSGGDAQRAAPVESRTVQDELPSGEARLDPEPDVSILRQE
>NZ_CP023689.1|WP_107909163.1|7741907_7742813_+|S1-family-peptidase
MRIKRTTPRSGITRRTRLIAVSTGLVAAAAIAIPNATAAETPATFSAAQLKSASGSVLKADVPGTAWSVDSKTNRVTVTVDSTVSKAEIAKIKEQAGANADALTIKSVPGKFSKFIQGGDAIYASSWRCSLGFNVQDSSGNQYFLTAGHCTDGAGTWWSNSGHTSVIGSTAGSSFPGNDYGIVRYSGSVSRPGTANGVDITRAATPSVGTTVIRDGSTTGTHSGRVTALNATVNYGGGDVVGGLIQTTVCAEPGDSGGSLYGSNGTAYGLTSGGSGNCSSGGTTFFQPVTEALSAYGVSVY
>NZ_CP023689.1|WP_150507039.1|7740283_7741501_+|hypothetical-protein
MCGLCLSLRGDHGQFARIVTNYDGLLISVLTEAQAENAGGLRRTAGPCPLRGMRTASVAQGEGARLAAAVSLVLASAKVRDHVTDGDGLLARKPVALAARRVAAGWGAAGARGGSAVGFDTAVLVDAVDRQVGIETLAGLGTSVLTVTEPTETATAAAFAHTAILAGRPGNAEPLAEVGRMFGRLAHLLDAVEDRAADAEAGAWNPLTATGTSLAEARRLADDAVHGVRLALREVEFTDPGLAHLLLVHELRRSVDRAFGTVPTCGSHASHASHQPGQPGPYGQPPQQPGPYGAPQNPYAGGGNPYAGGNPYAGGGGAPGGGAGGSGGGGGDFGGFGGFGGGPAPQPPKRRGFWAGCGMFWLLCCTCKLCCAKEYEGPWSRKKREGCCRDCDCDGCDCCCPCDGC
>NZ_CP023689.1|WP_030954768.1|7739454_7739892_-|cell-division-protein-SepF
MGSVRKASAWLGLVDDNDDERYYDDDYSEGTEPGEAWVTDPRVKVATDVAEEKGRRIGTVTPDSFRDARAIGELFRDGVPVIMNLTAMEPADAKRVVDFAAGLIFGLRGSIDRVSNRVFLLTPADTEIISGERAAHREDGFYNQS
>NZ_CP023689.1|WP_125527906.1|7738228_7739419_+|acyl-CoA-dehydrogenase
MSASSKLPPFDPADPLGVDDLLEPEDLAVRGTVRAWAADRVLPYVAEWYEKGELPGIRELARELGEIGALGMSLEGYGCAGASAVQYGLACLELEAADSGIRSLVSVQGSLAMYAIHRFGSEEQKQTWLPRMASGEVIGCFGLTEPDHGSDPGSMRTYAKRDGSDWVLNGRKMWITNGSVSGVAVVWAQTDEGIRGFVVPADSAGFSAPEIKHKLSLRASVTSELVMDDVRLPADAVLPEVVGLKGPLSCLSHARYGIVWGAMGAARSCFEAAVDYAKTREQFGRPIGGFQLTQAKLADMALELHKGILLAHHLGRRMDAGRLRPEQVSFGKLNNVREAIDICRTSRTILGANGISLEYPVMRHATNLESVLTYEGTVEMHQLVLGKALTGLDAFR
>NZ_CP023689.1|WP_150503883.1|7736497_7738105_+|MFS-transporter
MSGTTTAAAALRRRAAGAGANRWVVLVVLCVSLLLVAVDATVLHVAVPAVTEDLRPGAIELLWIVDIYPLVCASLLILFGTLGDRVGRRRVLLLGYGLFGLASGLAALAHDPQVLILARALLGVGGAMIMPATLSILRQVFPDRRERALAIGIWSAVAAVGAAVGPLLGGFLLEHFWWGSVFLVNIPLMLVSLPVGRLLLPESKGDHKGPWDVIGALLAAAGLFGVVLGVKRLGGGEPVASLFTLVPLVVGAAMLILFVRRQRRRTYPLVDLKMFARPAFSTSVGCIVLAMLALVGLELIAAQYLQLVLGLSPLETGLRLLPLTFAAMASGLAGARMLRRFGPRRMVCAGFCLTALAVVVLTAMGGEDNPGLLLVGFVLLGFGLETTLFGAYESMLSEAPQEQAGGAAAIGETSYQLGAGIGIALLGSVMNAAYAPGLSAVSGVPDSASTAASHSLGEAYEVAGQLGGSAGAALQHAARNAFVHGLHVTLLVSAGLLLLGAAMALRLPRTMQCEADAESVELPKPREVAETRVSA
>NZ_CP023689.1|WP_150503881.1|7735034_7736063_-|phosphatase-PAP2-family-protein
MRTERKLTRLDRVFARLDREPERPAHIDVPRMTRHRIVLFSATLAFYGAIVWAVVITSWLVRLDWQVMFFRPYQQWAEIHAFVDYYVVLGQRGPTAVMVAAWLGWRSWRQHTLRPLLALGVSLLLLNITVGAAKIGMGRLGPHYATTIGSNEMGLGGDIFPSGHTANAVVTWGILAYLASTPRARRWLSALSAVTSLGVGLSTVYLGTHWLSDVLLGWAAGLLILLALPWFEPLIARSEAWLFALRDRLRARRAGALPATAPVPVEAPVLLKPRPTASGDEAAAREASPPARSPRAPVYLAPGPHTARGERTPVTPAGSRRPPHTDRIGRGGTPTARPLTGG
>NZ_CP023689.1|WP_107909159.1|7734728_7734944_+|proteinase-inhibitor-I78
MAPIPKPPADPQDNPDAYVGLDADGAERLARERGWSTVRSLPPGAIITMEYRVGRLNFEVKDGQVARAWKG
>NZ_CP023689.1|WP_150503879.1|7731654_7732695_+|WYL-domain-containing-protein
MLDTSARLLRLLSLLQAHRDWSGAELAGRLGVTPRTVRRDVDRLRELGYPVNASPGTGGGYQLGAGAELPPLLLDDDEAVAVAVGLRTAAGQGIEGIGETSVRALAKLEQVLPNRLRRRVSALNAFTVPMLRGPQPSAVDPAVLTELANLCRDSERLRFEYRDHEGASTRRSVEPHRLVCSERRWYLVAWDLDREDWRTFRVDRVIPKPPHGPRFAPRTPPAEDLAAYVSRGVSTRAYAAQAVVRLLVPLAEAAERVSPTAGQLEAEGPDSCLLRTGAGSLDVMVIHVMLMGFEFEVLEPAELVETIRTAQSRLARSLARAAEPPARAADGADRTPGTPSGPSAAS
>NZ_CP023689.1|WP_150503885.1|7745607_7746687_-|ABC-transporter-permease
MTQTPGAGTPHPSFLAEVKDAVTPRATILVTGTVVLALLFIASYVGALHDPKPKNVPLGVVAPEVAAQQTVDRLQNLPGDPLDPRALPDVETARDQILDREIDGALVIDPTTTTDTLLVATGGGRALAATLESLVATLERSEARTLRVVDVAPADRHDANGLTSFYVTVGWCVGGYLCASIITISSGARRPTLRRSVIRLIVMALVAAVAGLGGALIVGPILGALPGSIAALWGVGTLIVFAVGAATFAFQAVFGMAGIGLVILIVVILGNPSAGGALPPPLLPPFWHDIGPALPPGAGTWTTRSVAYFNGNDTTGSLLVLSAWAVAGAAITLLAAALRGKDRTPKEPAAPGPTATATP
>NZ_CP023689.1|WP_150503887.1|7746851_7750298_+|DNA-polymerase-III-subunit-alpha
MSGFAHLHTASGFSLRYGASHPERLAERASERGMDALALTDRDSLGGAVRFAKACAAAGVRPLFGVELAVEGFGVPEGGAGRRRAPVWGGAFVDESTPRVTFLGRDGARGWGDLCRIVSAAHGGEGAPMLPREDNRGDGLIVLLGPDSDVGRALAAGRPDRAARLLVPWREIYGHSLRLEAVWHGRKGTGPGSLRLAARTVGFAAEQQLRPVLSNAVRYADPGLGPVADVLDAARRLVPIDSTKELDSGEAWLKGAGDMARVAERVVEAAGFRRDTGYRLLEQTGATAAECLVDPEDDLGIGTVHFPEPHLVGAGWRSAQRALASRAAAGMVLRGYDGRRAYWERVHQELDIIAHHGFASYFLTVAQVVDDVRRMGIRVAARGSGAGSLVNHLLGIAHADPVEHGLLMERFLSKRRPVLPDIDIDVESARRLEVYRAIIDRFGTERVATVSMPETYRVRHAVRDVGAALSMDPADIDRIAKSFPHIRARDARAALEELPELRQLAGERERYGKLWELVEALDALPRGIAMHPCGVLLSDASLLSRTPVMPTSGEGFPMSQFDKDDVEDLGLLKLDVLGVRMQSAMAHAVAEVERATGERVDLDGVADGDPATYRLVRSAETLGCFQIESPGQRDLVGRLQPATFHDLVVDISLFRPGPVAADMVRPFIEARHGRAPVRYPHKDLQGPLRETYGVVVFHEQIIDIVHIMTGCGRDEADRVRRGLSDPESQGRIRVWFAQHAAAKGYDAETIGRTWEIVEAFGSYGFCKAHAVAFAVPTYQSAWLKAHHPAAFYAGLLTHDPGMYPKRLLLADARRRGVPILPLDVNASGVAHRIELVSESGESKSSRKVWGLRLALSDVHGISEAEAARVADGQPYASLLDFWERARPSRPLAQRLAQVGALDAFGANRRDLQLHLTELHRGARSGGGGQLPLAGGRKTAAAGLPDLTSAERLSAELGVLSMDASRNLMDDHRAFLDELGVVSARRLRDAGHGESVLVAGAKAATQTPPIRSGKRVIFSTLDDGTGLVDLAFFDDSHDACAHTVFHSWLLLVRGVVQRRGPRSLSVVGSTAWNLAELIELRAEGGLDVVAARLAEPVAAPEGDDGDPARGRRIQMPTGYELNPWADLRPAGQEPSQVRKLWHQSPGSAG
>NZ_CP023689.1|WP_150503888.1|7750294_7751263_+|hypothetical-protein
MTILCVRFQLPPTREAALPGLLGLLEDFTPVVQALPPDAALADLRGAERYFGRDAVELASVIRVRALAHHGVDCAIGAGPGPMLARVALGEARPGVTCAVPEDAATEFLADKPVAALPGVGAATARTLCEYGLDTLGLVAAAPLSTLQRLIGAKAGRELREKASGIDRGRVVPDGVSRSLATERPFTRDELDPDRHRRALLSAAEELGARLRALDKVCRTLTLTVRYADRSSTTRSRTLKEPTAHSAALTRAAYGMYEALGLQRARVRALALRAEGLDPAEQASYQLTFDPLDEKARRIEEVADRARAKFGPHAVMPGSLAA
>NZ_CP023689.1|WP_150503890.1|7751279_7751654_-|cupin-domain-containing-protein
MPVIRASEAVTHEIHGARFVSYATPGTGSKELCAWRGEIPAGTKAPAHTVNREEILHLLDGELLVTLDDRTDRITAGDTLIINPGATLTVENPTGRTAVTWVTTSIGLTAELADGTVITPPWAN
>NZ_CP023689.1|WP_150503892.1|7751767_7752214_+|MarR-family-transcriptional-regulator
MQNSEAMALSAALLAVAGELTQRINDGVVARGFEGVRPAHGFAFARLAPAGATVTDLAVHLGVTKQAASQLVDEIVRKGYAERRPHPDDARARLVVLTERGWACTRAAEEAAAEAVRGWADVLGEAQVRALLGQLARIAPNGPIRPAW
>NZ_CP023689.1|WP_150503894.1|7752387_7753260_+|alpha/beta-fold-hydrolase
MLPWKRVLRPLAALLLTAAVAVVPAATTAQAAETAAAPSRGWNDYSCKPSAAHPRPVVLVHGTFANSVDNWLGLAPYLKDRGYCVFSLDYGQLPGVPFFHALGPIDKSAEQLSAYVDKVLAATGAAEADLVGHSQGGMMPRYYLKFLGGAGKVNALVGIAPNNHGTTLSGIANLLPYFPGAEDLLSAATPALAQQVVGSDFMTKLNAGGDTVPGVRYTVIATKYDEVVTPWRTQFLTGPDVKNVLIQDLCAVDISEHALIGITDRIAFHEVANALDPAHARPTTCASVFS
>NZ_CP023689.1|WP_150503896.1|7753363_7754401_-|LPXTG-cell-wall-anchor-domain-containing-protein
MSARRKAAAVATLGLTPLALTALAAAPASAHGSMGDPVSRVSQCYAEGPESPKSDACKAAVAAGGTQALYDWNGIRIGDAAGRHQELIPDGKLCSANSEEFKGLDLARADWPATSVSSGSYTFKYRVTAPHKGTFKVYITKAGYDPAKPLAWGDLDLSNPVATVTDPAASGGFYTFSGTLPQRSGKQLLYAVWQRSDSPEAFYSCSDVAFGGASGGGTSNGGGSTGSGSGSGDSNTDASAAPSASAPSEEQIEAGADQSTIEHHGHGDQDASTSAEPVAAAEDDASTAPANRPKAAGATENLAETGGDSSTAYLAMGGAATLALGSAVLFASVRRRAAAGGRHGR
>NZ_CP023689.1|WP_150503898.1|7754629_7755529_-|DUF4436-family-protein
MRPGRPAAPADSPRPGRSRRSVLRVLVLIAILIVVAVAVGSWLQFSERQRADTVHTVGSSDADRVDVEAAVQSVDAAGRELVLRVWVTPRGSLGEKGGAAPVADLSLQTSGATLGDLEFAAHERLATRDVQVALRGGSISDYPFDTYETDIAFRAQMGGEQVPVRMLFSNNDTLFSASAEPVPARQEAVVALELTRSGSLLVFAVFMMVAMWALAASVLIGAWYLTTGSEGLVWPGLAWMAATLFALAAFRNTAPGTPPIGCALDWFAFLWAESIIALCLVTVVITGVNKSLRKDAPPA
>NZ_CP023689.1|WP_150503900.1|7755714_7756164_+|GNAT-family-N-acetyltransferase
MTTEEIRPATAADVPAVKAVTDAAYTPYIERIGVTPVPMTADHAADVAAGKVFVTGDPVLGLVVIEAHEDHLFLDSIAVHPDAHGRGVGRRLLHFVDAHARALGLPEVRLYTNALMWENQKIYPKYGYELVERRAVGPYDRVHYRKRLT
>NZ_CP023689.1|WP_093745465.1|7756191_7756332_-|hypothetical-protein
MRRATVQKPLKRQSSTRRRVQEEAEESPSGRPEVRKDIARTWWPDS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP023689_7	7.1\|5172552\|21\|NZ_CP023689\|CRT	5172552-5172572	21	NZ_CP023689.1	5172873-5172893	0	1.0
NZ_CP023689_7	7.2\|5172615\|18\|NZ_CP023689\|CRT	5172615-5172632	18	NZ_CP023689.1	5172744-5172761	1	0.944
NZ_CP023689_7	7.3\|5172675\|27\|NZ_CP023689\|CRT	5172675-5172701	27	NZ_CP023689.1	5172771-5172797	1	0.963

1. spacer 7.1|5172552|21|NZ_CP023689|CRT matches to position: 5172873-5172893, mismatch: 0, identity: 1.0

ttccttcgagcgccgggacaa	CRISPR spacer
ttccttcgagcgccgggacaa	Protospacer
*********************

2. spacer 7.2|5172615|18|NZ_CP023689|CRT matches to position: 5172744-5172761, mismatch: 1, identity: 0.944

cggccgttcgttcgacgg	CRISPR spacer
cggccgttccttcgacgg	Protospacer
********* ********

3. spacer 7.3|5172675|27|NZ_CP023689|CRT matches to position: 5172771-5172797, mismatch: 1, identity: 0.963

tgggcgttccttcgagcgtcgcgacgg	CRISPR spacer
tgggcgttcgttcgagcgtcgcgacgg	Protospacer
********* *****************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP023689_7	7.3\|5172675\|27\|NZ_CP023689\|CRT	5172675-5172701	27	NZ_AP022319	Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence	1242620-1242646	6	0.778

1. spacer 7.3|5172675|27|NZ_CP023689|CRT matches to NZ_AP022319 (Burkholderia sp. THE68 plasmid BTHE68_p1, complete sequence) position: , mismatch: 6, identity: 0.778

tgggcgttccttcgagcgtcgcgacgg	CRISPR spacer
atcgcgtgccttcgagcgtcgcgccga	Protospacer
   **** *************** **.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1467275 : 1479082

Mycobacterium_phage(22.22%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_150498810.1\|1467275_1467677_-	hypothetical protein	A0A142F2J6	Mycobacterium_phage	2.0e-05	28.3
WP_150498811.1\|1467745_1468222_-	hypothetical protein	A0A1P8DIQ6	Virus_Rctr197k	1.2e-09	34.1
WP_150498812.1\|1468269_1468569_-	hypothetical protein	NA	NA	NA	NA
WP_150498813.1\|1468565_1468853_-	hypothetical protein	NA	NA	NA	NA
WP_150498814.1\|1469012_1469231_-	hypothetical protein	NA	NA	NA	NA
WP_150498815.1\|1469227_1469980_-	hypothetical protein	NA	NA	NA	NA
WP_150498816.1\|1470057_1470429_-	hypothetical protein	NA	NA	NA	NA
WP_150498817.1\|1470472_1470850_-	hypothetical protein	A0A0K0N7I1	Gordonia_phage	2.0e-20	40.6
WP_150498818.1\|1470901_1471216_-	hypothetical protein	NA	NA	NA	NA
WP_150498819.1\|1471212_1471518_-	hypothetical protein	NA	NA	NA	NA
WP_150498820.1\|1471514_1471823_-	hypothetical protein	NA	NA	NA	NA
WP_150498821.1\|1471819_1472575_-	hypothetical protein	Q6VY73	Streptomyces_phage	3.8e-42	47.8
WP_150498822.1\|1472571_1473480_-	hypothetical protein	A0A1J0MCP9	Streptomyces_phage	5.7e-45	43.6
WP_150498823.1\|1473479_1474118_-	HNH endonuclease	H6WG01	Cyanophage	3.1e-05	40.0
WP_150498824.1\|1474322_1474517_+	hypothetical protein	NA	NA	NA	NA
WP_167537656.1\|1474574_1474733_-	hypothetical protein	NA	NA	NA	NA
WP_150498825.1\|1474729_1475578_-	hypothetical protein	A0A2K9VHB5	Gordonia_phage	1.3e-14	31.8
WP_150498826.1\|1475574_1475910_-	hypothetical protein	NA	NA	NA	NA
WP_167537657.1\|1475906_1476047_-	hypothetical protein	NA	NA	NA	NA
WP_150498827.1\|1476046_1476382_-	hypothetical protein	NA	NA	NA	NA
WP_150498828.1\|1476378_1476648_-	hypothetical protein	NA	NA	NA	NA
WP_150498829.1\|1476718_1477354_-	hypothetical protein	NA	NA	NA	NA
WP_150498830.1\|1477350_1478217_-	hypothetical protein	A0A0R8VCS8	Thermobifida_phage	9.0e-40	52.1
WP_167537658.1\|1478209_1479082_-	hypothetical protein	A0A0K1Y659	Mycobacterium_phage	1.0e-46	39.7

DBSCAN-SWA_2

8595507 : 8668623

Bacillus_phage(11.11%)

plate,tail,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_150504732.1\|8595507_8597373_+\|tail	phage tail protein	J9PVC2	Bacillus_phage	2.1e-46	36.4
WP_004003113.1\|8597406_8597931_+\|tail	phage tail protein	NA	NA	NA	NA
WP_125526713.1\|8597957_8598686_+	hypothetical protein	NA	NA	NA	NA
WP_150504734.1\|8598678_8599419_+	hypothetical protein	NA	NA	NA	NA
WP_150504736.1\|8599452_8600370_+	DUF4255 domain-containing protein	NA	NA	NA	NA
WP_150504738.1\|8600403_8602389_+	AAA family ATPase	A0A109WUE1	Acidianus_tailed_spindle_virus	7.7e-10	34.6
WP_150507109.1\|8602451_8602739_+	hypothetical protein	NA	NA	NA	NA
WP_150504740.1\|8602735_8609602_+	DUF4157 domain-containing protein	NA	NA	NA	NA
WP_150504742.1\|8609639_8610278_+	hypothetical protein	NA	NA	NA	NA
WP_150504744.1\|8610274_8610970_+	hypothetical protein	NA	NA	NA	NA
WP_125526669.1\|8610980_8611367_+	hypothetical protein	NA	NA	NA	NA
WP_150504746.1\|8611359_8612499_+	hypothetical protein	NA	NA	NA	NA
WP_125526667.1\|8612537_8613074_+\|plate	baseplate assembly protein	NA	NA	NA	NA
WP_150504748.1\|8613096_8613432_+	hypothetical protein	NA	NA	NA	NA
WP_150504750.1\|8613428_8613821_+	GPW/gp25 family protein	NA	NA	NA	NA
WP_150504752.1\|8613817_8616922_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_150504753.1\|8616918_8620704_+\|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_150504755.1\|8620703_8622899_+	hypothetical protein	NA	NA	NA	NA
WP_150504757.1\|8622977_8624525_+	hypothetical protein	NA	NA	NA	NA
WP_107911789.1\|8624524_8625412_+	N-acetylmuramoyl-L-alanine amidase	A0A142K646	Streptomyces_phage	2.6e-90	58.4
WP_125526661.1\|8625567_8626536_+	1,2-phenylacetyl-CoA epoxidase subunit A	NA	NA	NA	NA
WP_030957096.1\|8626532_8626826_+	1,2-phenylacetyl-CoA epoxidase subunit B	NA	NA	NA	NA
WP_125526660.1\|8626836_8627664_+	phenylacetate-CoA oxygenase subunit PaaC	NA	NA	NA	NA
WP_150504759.1\|8627657_8628167_+	phenylacetate-CoA oxygenase subunit PaaJ	NA	NA	NA	NA
WP_150504761.1\|8628167_8629283_+	phenylacetate-CoA oxygenase/reductase subunit PaaK	C7BUZ5	Synechococcus_phage	6.9e-08	36.0
WP_150504763.1\|8629385_8631551_-	TerD family protein	A0A291I9M6	Lactobacillus_phage	4.2e-09	23.3
WP_150504765.1\|8631717_8632680_+	Dyp-type peroxidase	A0A0M5KAH8	Mollivirus	3.4e-19	30.1
WP_150504766.1\|8632704_8633097_-	hypothetical protein	NA	NA	NA	NA
WP_150507111.1\|8633240_8633969_+	LysR family transcriptional regulator	NA	NA	NA	NA
WP_150504768.1\|8633975_8634305_-	TfoX/Sxy family protein	NA	NA	NA	NA
WP_150504770.1\|8634419_8637242_-	glycosylase	NA	NA	NA	NA
WP_150504772.1\|8637429_8638884_-	S8 family serine peptidase	NA	NA	NA	NA
WP_150504774.1\|8639060_8639756_-	HAD-IA family hydrolase	NA	NA	NA	NA
WP_107911769.1\|8639775_8640255_-	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
WP_150504776.1\|8640450_8641947_+	FUSC family protein	NA	NA	NA	NA
WP_150504778.1\|8642155_8643205_+	beta-propeller fold lactonase family protein	NA	NA	NA	NA
WP_163017286.1\|8643272_8644154_-	hypothetical protein	NA	NA	NA	NA
WP_150504780.1\|8644316_8645294_-	ATPase	NA	NA	NA	NA
WP_125527555.1\|8645290_8645968_-	uracil-DNA glycosylase	A0A142CKK6	Brazilian_marseillevirus	1.1e-32	41.8
WP_150504782.1\|8646041_8647127_-	exo-alpha-sialidase	NA	NA	NA	NA
WP_150504784.1\|8647401_8647989_+	hypothetical protein	NA	NA	NA	NA
WP_150504786.1\|8648017_8649691_-	DNA alkylation response protein	NA	NA	NA	NA
WP_150504787.1\|8649766_8650522_+	PaaX domain-containing protein, C- domain protein	NA	NA	NA	NA
WP_150504789.1\|8650639_8651422_-	pectate lyase	NA	NA	NA	NA
WP_150504791.1\|8652013_8653327_+	PHB depolymerase family esterase	NA	NA	NA	NA
WP_150504793.1\|8653447_8657770_+	HAD-IC family P-type ATPase	M1HX51	Paramecium_bursaria_Chlorella_virus	6.3e-33	24.1
WP_125527538.1\|8657807_8658887_-	NADH:flavin oxidoreductase/NADH oxidase	NA	NA	NA	NA
WP_107911748.1\|8659037_8659391_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_150504795.1\|8659310_8660699_-	purine/pyrimidine permease	Q9KX94	Enterobacteria_phage	3.8e-32	33.0
WP_150504797.1\|8660791_8662135_-	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_150507113.1\|8662333_8662828_+	hypothetical protein	NA	NA	NA	NA
WP_167537817.1\|8662855_8663479_-	DUF305 domain-containing protein	NA	NA	NA	NA
WP_150504801.1\|8663608_8665105_+	hypothetical protein	NA	NA	NA	NA
WP_150504803.1\|8665092_8665797_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_150504805.1\|8665956_8666688_-	HAD-IA family hydrolase	NA	NA	NA	NA
WP_150504807.1\|8666821_8667493_-	phosphatase PAP2 family protein	NA	NA	NA	NA
WP_150504809.1\|8667687_8668623_-\|protease	M48 family metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP023689

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection