CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP044516	Leptospira interrogans serovar Canicola strain 611 plasmid p2, complete sequence	0 crisprs	NA	0	0	5
NZ_CP044515	Leptospira interrogans serovar Canicola strain 611 plasmid p1, complete sequence	0 crisprs	NA	0	0	0
NZ_CP044513	Leptospira interrogans serovar Canicola strain 611 chromosome 1, complete sequence	12 crisprs	WYL,csa3,cas3,DinG,cas6,cas1,cas2,cas8b3,cas7,cas5,cas8c,cas4,Cas9_archaeal	1	10	3
NZ_CP044514	Leptospira interrogans serovar Canicola strain 611 chromosome 2, complete sequence	0 crisprs	csa3	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 5517

Leptospira_phage(100.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_025176707.1\|1289_1499_+	hypothetical protein	NA	NA	NA	NA
WP_000041736.1\|3237_4107_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	NA	NA	NA	NA
WP_025176709.1\|4614_5517_+\|transposase	Rpn family recombination-promoting nuclease/putative transposase	S5VY82	Leptospira_phage	2.8e-145	87.7

DBSCAN-SWA_2

12854 : 13948

Leptospira_phage(100.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000697144.1\|12854_13139_+\|transposase	transposase	S5WIS5	Leptospira_phage	1.9e-10	87.8
WP_025178118.1\|13132_13948_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	4.7e-115	80.0

DBSCAN-SWA_3

33359 : 37357

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000608319.1\|33359_33977_+	hypothetical protein	S5VTG9	Leptospira_phage	4.5e-25	34.9
WP_001011725.1\|33997_34906_+	membrane protein	S5W9K9	Leptospira_phage	5.4e-27	31.9
WP_000841761.1\|35362_35764_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000611563.1\|35913_36138_+	hypothetical protein	NA	NA	NA	NA
WP_002115821.1\|36157_37357_+	AraC family transcriptional regulator	S5WIW9	Leptospira_phage	1.5e-165	75.2

DBSCAN-SWA_4

42737 : 56882

Leptospira_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_057139924.1\|42737_49841_-	type IV secretion protein Rhs	S5VY91	Leptospira_phage	1.5e-278	32.2
WP_000159582.1\|50439_51324_+	hypothetical protein	S5VSU6	Leptospira_phage	2.9e-134	80.3
WP_082271549.1\|51509_52811_+	hypothetical protein	S5VKK9	Leptospira_phage	5.4e-222	86.1
WP_000835585.1\|52819_53443_+	tetratricopeptide repeat protein	S5VKQ0	Leptospira_phage	4.1e-50	57.4
WP_002115796.1\|53623_55063_-	hypothetical protein	S5W9F7	Leptospira_phage	4.3e-196	75.1
WP_001274836.1\|55437_56142_-	hypothetical protein	NA	NA	NA	NA
WP_000451903.1\|56138_56882_-	AAA family ATPase	E9LUK9	Lactobacillus_phage	7.3e-06	24.3

DBSCAN-SWA_5

62082 : 63225

Leptospira_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001969248.1\|62082_63225_+	cytochrome c554 and C-prime	S5VL21	Leptospira_phage	1.2e-196	85.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP044513

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP044513_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_1

1084737-1084907

Orphan

Consensus_repeat	Method
GTTTCTTTCTCTTATTCAAGAAGAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP044513_1

>merge|NZ_CP044513|1|1084737-1084907|CRISPRCasFinder
GTTTCTTTCTCTTATTCAAGAAGAAGTGGATTGAAACGATTTGAGTTGTCGGGTTTGCCGCGTTTTCCATCGGGTTTCTTTCTCTTATTCAAGAGAAAGTGACTTGAAATGTCGGTAAAGTGGCCAAAGGCGAAATGGAAGTTCGTTTTTTTTCCTCTTACTCAACATGAG

>NZ_CP044513|1|1|1084737-1084907|CRISPRCasFinder
GTTTCTTTCTCTTATTCAAGAAGAA	GTGGATTGAAACGATTTGAGTTGTCGGGTTTGCCGCGTTTTCCATCGG
GTTTCTTTCTCTTATTCAAGAGAAA	GTGACTTGAAATGTCGGTAAAGTGGCCAAAGGCGAAATGGAAGTTCGT
TTTTTTTCCTCTTACTCAACATGAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_002117311.1\|1079359_1081306_-\|sphingomyelin-phosphodiesterase	unknown	unknown	gnl\|CDD\|132436
NZ_CP044513.1\|WP_000848056.1\|1083094_1083922_-\|crotonase/enoyl-CoA-hydratase-family-protein	unknown	unknown	gnl\|CDD\|235714
NZ_CP044513.1\|WP_000808193.1\|1091268_1093752_-\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|227342
NZ_CP044513.1\|WP_001010757.1\|1081953_1082802_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_CP044513.1\|WP_000687879.1\|1069006_1070170_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225114
NZ_CP044513.1\|WP_002071355.1\|1076661_1078446_-\|sphingomyelin-phosphodiesterase	unknown	unknown	gnl\|CDD\|132436
NZ_CP044513.1\|WP_061294286.1\|1085894_1087274_-\|response-regulator	unknown	unknown	gnl\|CDD\|381089
NZ_CP044513.1\|WP_000838285.1\|1096156_1096873_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|133009
NZ_CP044513.1\|WP_082269420.1\|1088741_1088945_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001024527.1\|1082913_1083093_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000576391.1\|1089585_1090704_-\|M23-family-metallopeptidase	unknown	unknown	gnl\|CDD\|366703
NZ_CP044513.1\|WP_000179607.1\|1067410_1068859_-\|transcription-termination-factor-Rho	unknown	unknown	gnl\|CDD\|236490
NZ_CP044513.1\|WP_085977014.1\|1084925_1085036_+\|SLEI-motif-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001190627.1\|1094910_1096179_+\|diaminopimelate-decarboxylase	unknown	unknown	gnl\|CDD\|143501
NZ_CP044513.1\|WP_151442356.1\|1070667_1074852_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|273344
NZ_CP044513.1\|WP_000947942.1\|1074860_1075886_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293789
NZ_CP044513.1\|WP_000907505.1\|1093758_1094835_-\|zinc-dependent-phospholipase-C-family-protein	unknown	unknown	gnl\|CDD\|376406
NZ_CP044513.1\|WP_000698723.1\|1087600_1088683_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|310523
NZ_CP044513.1\|WP_001973969.1\|1084032_1084227_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000974282.1\|1090756_1091167_-\|polymer-forming-cytoskeletal-protein	unknown	unknown	gnl\|CDD\|377376

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_002117311.1\|1079359_1081306_-\|sphingomyelin-phosphodiesterase	gnl\|CDD\|132436	TIGR03395, Sphingomyelinase_C, sphingomyelin phosphodiesterase. Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins. [Cellular processes, Pathogenesis].	7.23967e-180
NZ_CP044513.1\|WP_001190627.1\|1094910_1096179_+\|diaminopimelate-decarboxylase	gnl\|CDD\|143501	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase. Diaminopimelate decarboxylase (DapDC, EC 4.1.1.20) participates in the last step of lysine biosynthesis. It converts meso-2,6-diaminoheptanedioate to L-lysine. It is a fold type III PLP-dependent enzyme that contains an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. DapDC exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Homodimer formation and the presence of the PLP cofactor are required for catalytic activity.	5.22142e-133
NZ_CP044513.1\|WP_000808193.1\|1091268_1093752_-\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|227342	COG5009, MrcA, Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane].	0
NZ_CP044513.1\|WP_001010757.1\|1081953_1082802_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	4.44011e-09
NZ_CP044513.1\|WP_000687879.1\|1069006_1070170_-\|hypothetical-protein	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	5.55391e-05
NZ_CP044513.1\|WP_002071355.1\|1076661_1078446_-\|sphingomyelin-phosphodiesterase	gnl\|CDD\|132436	TIGR03395, Sphingomyelinase_C, sphingomyelin phosphodiesterase. Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins. [Cellular processes, Pathogenesis].	1.67724e-173
NZ_CP044513.1\|WP_061294286.1\|1085894_1087274_-\|response-regulator	gnl\|CDD\|381089	cd17534, REC_DC-like, phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains. This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	3.91779e-61
NZ_CP044513.1\|WP_000838285.1\|1096156_1096873_+\|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase	gnl\|CDD\|133009	cd02516, CDP-ME_synthetase, CDP-ME synthetase is involved in mevalonate-independent isoprenoid production. 4-diphosphocytidyl-2-methyl-D-erythritol synthase (CDP-ME), also called 2C-methyl-d-erythritol 4-phosphate cytidylyltransferase catalyzes the third step in the alternative (non-mevalonate) pathway of Isopentenyl diphosphate (IPP) biosynthesis: the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate. This mevalonate independent pathway that utilizes pyruvate and glyceraldehydes 3-phosphate as starting materials for production of IPP occurs in a variety of bacteria, archaea and plant cells, but is absent in mammals. Thus, CDP-ME synthetase is an attractive targets for the structure-based design of selective antibacterial, herbicidal and antimalarial drugs.	7.96956e-79
NZ_CP044513.1\|WP_000848056.1\|1083094_1083922_-\|crotonase/enoyl-CoA-hydratase-family-protein	gnl\|CDD\|235714	PRK06142, PRK06142, crotonase/enoyl-CoA hydratase family protein.	2.04034e-111
NZ_CP044513.1\|WP_000576391.1\|1089585_1090704_-\|M23-family-metallopeptidase	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.09598e-44
NZ_CP044513.1\|WP_000179607.1\|1067410_1068859_-\|transcription-termination-factor-Rho	gnl\|CDD\|236490	PRK09376, rho, transcription termination factor Rho; Provisional.	0
NZ_CP044513.1\|WP_151442356.1\|1070667_1074852_+\|hypothetical-protein	gnl\|CDD\|273344	TIGR00927, retinal_rod, K+-dependent Na+/Ca+ exchanger. [Transport and binding proteins, Cations and iron carrying compounds].	1.34343e-34
NZ_CP044513.1\|WP_000947942.1\|1074860_1075886_+\|hypothetical-protein	gnl\|CDD\|293789	sd00042, LVIVD, LVIVD repeat. LVIVD repeats are mainly found in bacterial and archaeal cell surface proteins, many of them hypothetical. Structurally, LVIVD repeats have been predicted to form a beta-propeller, with each repeat forming one four-stranded anti-parallel beta-sheet blade.	3.93503e-10
NZ_CP044513.1\|WP_000907505.1\|1093758_1094835_-\|zinc-dependent-phospholipase-C-family-protein	gnl\|CDD\|376406	pfam00882, Zn_dep_PLPC, Zinc dependent phospholipase C.	2.32431e-14
NZ_CP044513.1\|WP_000698723.1\|1087600_1088683_-\|alpha/beta-hydrolase	gnl\|CDD\|310523	pfam05990, DUF900, Alpha/beta hydrolase of unknown function (DUF900). This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.	1.22522e-84
NZ_CP044513.1\|WP_000974282.1\|1090756_1091167_-\|polymer-forming-cytoskeletal-protein	gnl\|CDD\|377376	pfam04519, Bactofilin, Polymer-forming cytoskeletal. This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localization and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	2.86208e-23

>NZ_CP044513.1|WP_001973969.1|1084032_1084227_+|hypothetical-protein
MIISWEKIRHQHPKEEWKRLLEKVERGSSHIFTEKRFWYNSTETEENHSYSILYRAKQIRKKPK
>NZ_CP044513.1|WP_000848056.1|1083094_1083922_-|crotonase/enoyl-CoA-hydratase-family-protein
MKTHFEFFEIVPKPEDKTAILYLNRPEKRNAMNWPFWRDLPDTIEEINSNPDIHSFVIAARGKSFSTGLDLDSFIQQFGSIIQAPLGSDRRKFFDLILKMQKGINAVYDSPKPSIAAVQKHCIGGGLDLISACDIRYATVDASISLREAKVAIVADMGSINRLPSIIGQGHTRELALTGKDIDGPEAERIGLVTKVFSTEEEMMNAALATAKEIAENPKIVVSGIKDVMRYSEGKPLDAGLNYVALWNSSFLDSADFRGAMQSFRERKRPVYNQS
>NZ_CP044513.1|WP_001024527.1|1082913_1083093_+|hypothetical-protein
MNINGNANQSLLLERVANLPKEIFQIQSDLNRKMLNLAVEAGVQNLKEEGQRKILDIYA
>NZ_CP044513.1|WP_001010757.1|1081953_1082802_-|hypothetical-protein
MNFPTLIRSAIQRENQREFTKAFNLYKEALSFTSNPKTILKILNRQAWCQYHIGNTRETLNLFQEIISKYSKEPESYLYYSNYLIKINNFKQAKKILTKGIDLYPDQLELYLTLASLLKDTDRSNEAITVLKQALAQEKLSRGKGILRKDIWAELGNLYYQRGNYNSALVSLKTSMRMDNDENFLHYDMIAQCYLKVADHKNALKFIDLYIQYFGESDSDILIIKARAHAQLGENHLACASLLQAYSMENGLKLNAEDMIDFAPLLQTGFFDTLENVEIEDP
>NZ_CP044513.1|WP_002117311.1|1079359_1081306_-|sphingomyelin-phosphodiesterase
MINKITKPKLLIGYYLLLFSLIRCLPEKESSYKDLFTSLLFLPNQTNSNQVNSVSINNDPANPNPVNPASANNNQVNAVPENDNPANLNPVNPASANSNQVNAVPENDNPANLNPVNPASANSNQVNAAPENGSPTDPNPANLASANNNQVNAVPANNYFTKEDSSNNIPKKVNSKNVEIKVLSHNVFMLPTNLPRWGNWGHDERAKRISKSDYVKNQDVIVFEEAFDTSARKILLDNLREEYPYQTDVVGRTKKNWDASLGNFRSYSLVNGGVVILSKWPIEEKIQYIFNDSGCGADWFANKGFVYVKINKEGKKFHVIGTHAQSQDQNCSNLGVPNRANQFDDIRNFIYSKNIPKDETVLIVGDLNVIKESNEYYDMISRLNVNEPRYVGVPFTWDAKTNEIAAYYYENEEPVYLDYIFVSKSHAQPPVWQNLAYDPVSKHTWTVSGYTSDEFSDHYPIYGFVYADPSTPTKSGHKKKYDQVSFQSAANGKYIQADPNRKNGWLKADAVIETDFTKFNLLQEGNLNPSCIKNGLVRIESSRFLNYFWNWWLGGGSGNYGYYSKFNDASNQLEIINLSDGCLENGSKIVFKDYDTYSRNHYYLTVWDKGNWNEHLYLWKDSISQREIFYLKLNSTPVRNWGADLIYR
>NZ_CP044513.1|WP_002071355.1|1076661_1078446_-|sphingomyelin-phosphodiesterase
MITKRNIPCKKNWKYKKKSISLTLITICYMFLFLTSCKPGKQNSINLLLLLLNTLDNKNVNEKIEDSTNTDPSSNVNEEDENSTNANDNAPSDSDSSNPRSPDKNPVNPTSPNSSSADIGIKILSHSIFMAPTNLSSWGDLGQEERAQRIASSSYIKNQDIIVFEGLSHNNAEKILLEKIRSEYPYQTNVVGRTKKGWNATLGAYTTSPMANGGVIIVSKWPIEEKVQYIFNNSNCGQDQYYNKGFAYVKINKDGKKFHIIGTQLQAREPDCFNSGETIRKLQLNDIKSFIDSKDIPKDETVLITGDLNIIKGSNEYFDMISKLNVNEPRYVGVPFTLDTKTNALAAYYYEKEKPIYLDYIFVSKLHAQPPVWQNLAYDPISNTTWKRSDGYTSYEFSDRYPVYGFIYADSSTPTKSGHKRKYDQVSFQSTFNRKFIQADHNRKDGWLKADTRIKTDFTKFNLLQENVSESNPSCMNSGSVRIESSYYLNYYWNWFIGAASGDYGYYTKFNNGSDSLGIKNLDNGCLKDGSRVAFYDWDTIGGGYYYLTVWDKGSWKEHLFLWVQSFLSSREIFYLHLDSNPPKDWSKDLIYHH
>NZ_CP044513.1|WP_000947942.1|1074860_1075886_+|hypothetical-protein
MLSFHLELLDKIFLKNVNQFLVYKDYVFVYGDYGQAHEIHILSLEIPEKLTHVQSISFQKEIVKVEIKDDTLYVIENERALHIFDLSNVSDPKRVDSFVLLGYDIYDMKLIGENAILAMNWEGIGLVDLNLPDQIQPVQKLKIENKCVECFVPFGDRIFTVSNLKNDPFLYEVSIINGYLEIKNKKEFSDFNPSNVFCGASEIILYGEFKKGKNNRSGILLLDYNLQPLGESIRLERSPIICFQLSDGNFLFGFDYSYVLLDKTQRVIVPLFAQFKQRSSNEYVEVVSNSDSGLEPRDTSKLVSMDSLQNAHRQGDFFFALHGNHFISFKILENSLFRNII
>NZ_CP044513.1|WP_151442356.1|1070667_1074852_+|hypothetical-protein
MIFRPKDFQKKTIPKYYSDYFERLNHFDFEGAIKLLEKIFQDERNQNKKGKPTDFLNEKKEYKSLSVRFQEMLDGFHFSEPLSKKVDLVLKHLEESFNPENLRIYRFKPFNGFLFKMSDDGFSSAVLNSIHFDPETREVSNVFGLNHEIIFEKDSYPSGEDVEETEENSSELYDFIYDMEEGKYSIYYQEEKIEGKDLHVHTKLLLFAKMIREIVDKLLLDERFARFPKVFPFYVLVNSEECYSYTQELFFLEILPSIELQSLRENPNFTLYETSSKIENSISAKEEFLFYLKFLDQQDSREFQTLLRIVDSNPEFQSILEELALDSLNYNFEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEEDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEEDEEDEEDEEDEEDEEDEQDEQDEQDEQDEQDEQDEQDEQDEEDEEDEEDEEDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEQDEHARVRDFEPHLFSSFFWKLAQFNPKSHLENARSFQNKVFFRSPPPLVDSYKIAIPNINNFSYVLFDSYLSIPEEYRSEFYNSFEETLNQMKSLAHPGFKILAMEIEARFKSNQLDSGENPIYLDPPEEFIDVIIDLIHCMPKKFPWFGEAWDFIFEDRLLSLGKKAKRAVPAVIEVMERYNYEDSTRNLATILYNIGCDDIPSLVHELHKENEFYMEEFYDQWSKQAPAVRWAYFLDRFENFPEDFARSEIWEDLLYDSEPGFLVYYENIEKSVNRNRIFYAFLKALKNDPQDVPFRFALFYAEKLRNKAKKNRENFFQIISEMTEILKLLNVYEKLNSKQKVYLECGIVAKSIEAFLLEKVDALDIFNKTLSKNHLLVFLKVAYIEKKEGVKRGMEELRQILPIFWKDDLILSKAFFLYLLFPNQNWDEIPFGKLYAFYTKVRFVFQNHFFRDGNFVADLESFDMNLFIDVLKEEYSKLEIESHKAWVQNQAEEYFLFESLGSASEKELVTFLKPGNLSLNLSIVSKLLRSSKNFSKEFLQLLEWETEEASIFQILKLYYPNEFLKEELLQNSVFHTHLSFFIRNYKGVSSRELAKFIFSKLKEKQNSLVIVETIKGLDPDTIIYCFFSVYWAFQNENRLNEFESILIQILKDLDQRKPEYVLIATNLGVLQIEIGNLEIAKQTFDSIFSMDWSHFDYTKESELMDKILGEDLDKQYSDIFRKYYALAKFNAACLYSKLQDPEKSVFYLKEATFLEPEIYNRVKILSEKDFLSIEHHEIYKEFINSLN
>NZ_CP044513.1|WP_000687879.1|1069006_1070170_-|hypothetical-protein
MKIETIYKYFLLTPSTHLPVVDNSGKLIGLLSRKLIQMEMADLSNSEKEYAQIPESFLETDIPESFFQYFQRQKSIPVLSTTGEKKEEWDKIQLMAELGQLVSANRPSAPPVTEVQKQEKEQNSRFWFMELILQNFPDGLLATDLEGGSLFYNETFEQNILPKKYFRDSIQQAERLLKEMSKNLLADYLKTNELRLDGSSTFSLQTYVTELECNVRIIVLKQNSKIVGYLYHFITPKAVLGRQDESGLEFPSIRDAFLQKLPLETMLKEVESSFIFYSLKANQDNISHTALQLGVPRTTLQNRIKFLDLQNRYSLSRENPIPRKKTSTTVYSTETQPNKNEKRPSLKKQTSKSTEVSKQTSTPKKSGKNRVKKNSSSKTAVKKRSRH
>NZ_CP044513.1|WP_000179607.1|1067410_1068859_-|transcription-termination-factor-Rho
MATARRDNKNRHQHSNHNHNNQNDSGDSFEEESTNQESQEFDSSENSDPRSRKRKRGGYEGPAPAPIDLVELKKKAISDLIEVAKGLGVENTGGLKKQNLIFAILQAQAERDGQVHAAGVMEKLPDGYGFLRSPDYNYVPGPDDIYVSPSQIKLFGLRTGDTVEGQIRPPKESERFFAMLRVETVNGYTPDVAGKRALFDNLTPLYPNERLKMEYDPSMLDTRILDLMCPIGKGQRALIVAPPRTGKTILMQNIANAITSNHPECSLIVLLIDERPEEVTDMARHVRGEVVSSTFDEPAQRHVQVAEMVIEKAKRLVEHGKDVVILLDSITRLARAYNQVIPTSGKILSGGVDSNALHKPKRFFGAARNIEEGGSLTIIATALIDTGSKMDEVIFEEFKGTGNMEIHLDRKLSDKRIFPAIDINKSGTRKEELLITKDVLQKVFVLRKVLSPMSITESMELLLEKMRLSKTNDAFLASMNTQ
>NZ_CP044513.1|WP_085977014.1|1084925_1085036_+|SLEI-motif-protein
MFVKSVICSSSHKAELVPKPQRILRNNSLEIFNKMQ
>NZ_CP044513.1|WP_061294286.1|1085894_1087274_-|response-regulator
MDMLQKPKILVVEDEIIVAVNLGQKLKKLGYELVGITSSGEEVIQKAEENHPDLVLMDINIEGNLDGIETAEVLRNRFHTPVIYLTAYADESTLDRAKKTEPLGYIVKPFESDQLRSSIEVALYKNEIEQRSKQTEEKLKGALDQLGAGIVTTDENGLLLFMNPAAEKLIGCKYEDYLGKPIRQILFFRNGSGNTVENLVEEVLKSGLPKDNGNLFLISKNGSSHEIQFQSSPIFGGEEKLTGTFNILRTKEQHTNNAEKDTYLKEIHHRIKNNLTIISSIFSLRSGQTTGESNDVLRESQNRLRAVALLHEILYESKDLSLISFELYVKKLTDALFQIYQVNREKVRLELNIQEGKVKAEIGMNLALIINELITNSLKHGLANSESGSIRVHFTKENDILVLEVSDSGNGLPEESIRKRNPSSLGLSLVESLAKQIGGKIDFINQEGACVQLRFPVSA
>NZ_CP044513.1|WP_000698723.1|1087600_1088683_-|alpha/beta-hydrolase
MKILRLLLSFLIFTSHCKTPTIEELLEKRLIKTYDQAETLNLYYATLRSQDPNAENGCNDSRFLTTADKEIKTGYCIVNVPANRDIGALPLGFGNRENFFQFLGHKPFANQENLIEDLKKDPHDEILVFVHGFNVKFEEAILRGGQIRFDLKFPGKMIIFTWPAGNEEVGLVSQVLLNQILLKKTYEKNLSSAKASKKEFKSFINYLQNAGKKIHLIVHSMGHQVVLPALSEIGKETDKPLIQELILNAPDFDSAEFRLISDSLIKSSKRITLYCSPGDNALQISASLNQGSRLGSCAPIEGFDVVNVNPVDSSLISIGHGYYSSRPLLTDIYQILLGVKAEKRLFIRKSSGNENFILRN
>NZ_CP044513.1|WP_082269420.1|1088741_1088945_+|hypothetical-protein
MILLHFQSLTVTFLNLPLECMKIIPENEWTILQRLGNSQKIISNFKSLFFLCEVPQISLLRNLKIFW
>NZ_CP044513.1|WP_000576391.1|1089585_1090704_-|M23-family-metallopeptidase
MIFKKPRQLTAGKEILRTESFTLIYLGAFHFHYSFYFRGNLYHGNLDFRRRKFRLIPIFASVVIFLAILGFGMNPSNAMIDSSGHEVTENDSEDLKAKSGDEKFLEESEKAKLTILMAKELKNSSEKKKQFKVTSYRVKRNETLAEIATRFKVSMESIAGSSNIKIEDTLYPGQVLSIPNKQGLLYKMKTGDTVAKVASLYKVNLDEIMLENKLDDLDILRPGQKVFLPGAVIPDPTPKWVIPVASRVVTSNFGFRTFPRKKFHEGLDLKAFYEPIAAARNGKVIYAGWMGGYGNVVVIEHTDDFKTLYAHNSKLFVQRGDYVLAGKKIARSGSTGYSFGPHLHFEVIKNGRPVNPSKYLKGLTFRKGGPTH
>NZ_CP044513.1|WP_000974282.1|1090756_1091167_-|polymer-forming-cytoskeletal-protein
MAIGRENNNSVIGPGSIFEGKFYIAGSLRIDGKFEGEIKTDDTLYIGETGKVRTNISAREVTVSGTMIGNIKAENEVRLEETGRLLGDIIAPALHLAKGVVAKGNITITGGQKKDVKKIVEESFGGTRTLDNGKDE
>NZ_CP044513.1|WP_000808193.1|1091268_1093752_-|PBP1A-family-penicillin-binding-protein
MKQEPVSYLFRFFVIHFRDKILSRVFNSENPLKQLVKLCSVLLFLNGFLFVFSIKDLWRVPESNQYEKPSVLYGLGEKNEYEPIAEFYRFSRVVLNIKELPPEADGKPNKLIRSFVSTEDNNFYSHWGLDLRGIFRAFMVNILAGRIKEGASTITQQVARLRFLNTERSFLRKAREAWLALLLEVVFDKDTLMEIYLNEIPLGHGTIGVGAAARFYFRKDVKDLTWGESALLASLTTRPTEFSPLVNPNSSSAKVRVVFKKFVENGILDVKTAEKEYESFSEYYITLNRSPNDSAFGDRLNRFPYFTEYVRKNLTRYIPKSTLYSGGLKIYSTLNIQHQTQAEKALYAGLKAQTALSNQRTFTKIDAFDDAYGEIYDLLSMLNDIPDFKFKISRSARTFNRAWQEDLRDELSALNLLSGTESLGETIDWNYKSQQTEDFLLPVEGALISMRPDTGYITAVVGGSGFRSDNQQIRAFQAYRQPGSAFKPIIYAAAMEYFNEHPDPKKNVTAASLFSDSPLQYVLEDGDEWNPSNYTGEYSGFIKLREALELSRNSVAVRVLEHTGISNLMPYLEKILQIENRPIPRNYSISLGTFEVSPYELARAYAVIASGGKQVFPLSVLYVEDGSGKVIKDFREEANKQEKKQILSPAVCFILTSMMEDVIKKGTGTGAASYGLSRPAAGKTGTTNNFRDAWFAGYSSELVSVVWLGYDTGTLSMGKGMSGGVVAAPIWGRFMSNALSREKSKPFHFGETGVVRKQICSISGKLPGSHCHQTEEEYFTKETVPKEVCDDHRGAGFIPEPEPTTHPTQPKKKQKTNIFQGDDDLIR
>NZ_CP044513.1|WP_000907505.1|1093758_1094835_-|zinc-dependent-phospholipase-C-family-protein
MAGKITHLEVLSQICKHLDHGTADQRKIAVLMRAESNRKFANIGAIAPDIFYFYHIFSPHKTKKATRWGDMSHHNLVAELVLSFLDLILQTEEGIHRDRYIAFTLGYICHCVVDIVTHPYIFYISGDFYNKDKKISSLAQYNHMRVENALDSWLLDYRWGMTPKEYDFVHHVDAIFKSEKKIWKMDPMLWHFWLRGLKSTFSEEFKKYYIGSEDKIIPGDLLNESFLGYLEFHKLMDSRSRWVRGTLKFLDQITFHKVRSSVLMLPLKEHIDKRIMNEEKKKWNYPADPSIVREDSFVELINSSAQNGKEALTHAWNYLENKMSRSAFLKEYQGYNLDTGLRFQGVDSMKEFSPLEEV
>NZ_CP044513.1|WP_001190627.1|1094910_1096179_+|diaminopimelate-decarboxylase
MQSIEKLKFLTESQVRSIAGQFGTPVFVYSRERIEKSCEVALAFPNAYGLTVRYAMKANPNRTVLEIMKRKGIQIDASSEYEVLRAIHYGFKPEQIMLTSQELAKGLKELVEKGVVFNACSLRQLETFGNLFPGKEVSVRFNPGLGSGQTKKTDVGGKTSSFGIWYEDINQVKEIASKFDLKIFKVHTHIGSGSDPEVWKVVAQVSLDIAAQFSECKILNLGGGFKVGRMEDEKTTDFQKIGPPVVELFQEFAKKHGTELRLEIEPGSFLMVNNGSILTTVDDVVSTGPGGYTFVKLDAGMDVNTRPSLYAAKHPLVVVSKEGVHSGKTADYVYVGHCCESGDLFTQAEGGGPITRITGEAKLGDYVVMEGAGAYCSSMSTKNYNSFPETAEVLVDSDGSFQLIRRRQNWEQIFQNEVTVSL
>NZ_CP044513.1|WP_000838285.1|1096156_1096873_+|2-C-methyl-D-erythritol-4-phosphate-cytidylyltransferase
MKSLFLSEKIYVLILAGGTGSRMGSKIPKQFLELNGEPILIHSLKRFQNWGKQKRIVLVSHSESIPKIESICASYLENEDRIVQGGENRHSSMLCGLSVLDFKDEDIILVHDAARPFVLADELDSLCEKVRSDGIATLASRTSETVLEELNGKTVSFLDREHVWFMKTPQGIRGDVLKELLTFSVDSIPTDLCSWALTFGKTSFIVESNPLNLKITRKEDLDLAEVFSSLFQKISSDV

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Crispr_ID: NZ_CP044513_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_2

1119262-1119357

Orphan

Consensus_repeat	Method
ATTTCTTTCTCTTGTGAAAGAGGA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of NZ_CP044513_2

>merge|NZ_CP044513|2|1119262-1119357|CRISPRCasFinder
ATTTCTTTCTCTTGTGAAAGAGGAAGTGGATTGAAACACGAGACGTTTTTGAGTGGTCTCTATCTAAACCAGATTTCTTTCTCTTGTAAAAGAGGA

>NZ_CP044513|2|2|1119262-1119357|CRISPRCasFinder
ATTTCTTTCTCTTGTGAAAGAGGA	AGTGGATTGAAACACGAGACGTTTTTGAGTGGTCTCTATCTAAACCAG
ATTTCTTTCTCTTGTAAAAGAGGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_001193044.1\|1132328_1132733_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_080035936.1\|1113488_1114589_-\|adenylate/guanylate-cyclase-domain-containing-protein	unknown	unknown	gnl\|CDD\|143636
NZ_CP044513.1\|WP_000458634.1\|1133306_1133708_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000777806.1\|1127471_1129496_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|273429
NZ_CP044513.1\|WP_000143803.1\|1129498_1130149_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000224797.1\|1117913_1118864_-\|fumarylacetoacetate-hydrolase-family-protein	unknown	unknown	gnl\|CDD\|376566
NZ_CP044513.1\|WP_000149356.1\|1107309_1108284_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372197
NZ_CP044513.1\|WP_001106691.1\|1110462_1111194_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000793003.1\|1121619_1122312_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000339870.1\|1122347_1124990_-\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|341065
NZ_CP044513.1\|WP_000915471.1\|1133825_1134158_-\|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|223713
NZ_CP044513.1\|WP_001173236.1\|1109572_1110463_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000195122.1\|1125129_1126386_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP044513.1\|WP_000953879.1\|1116652_1117177_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000808789.1\|1126387_1126966_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239516
NZ_CP044513.1\|WP_000827080.1\|1115454_1116540_-\|carboxylate--amine-ligase	unknown	unknown	gnl\|CDD\|237195
NZ_CP044513.1\|WP_002117205.1\|1130166_1132359_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000614736.1\|1108280_1108556_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000257955.1\|1108558_1109428_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000286980.1\|1112499_1113363_-\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|366166

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_000339870.1\|1122347_1124990_-\|aminopeptidase-N	gnl\|CDD\|341065	cd09602, M1_APN, Peptidase M1 family including aminopeptidase N catalytic domain. This model represents the catalytic domain of bacterial and eukaryotic aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
NZ_CP044513.1\|WP_000915471.1\|1133825_1134158_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	1.03389e-11
NZ_CP044513.1\|WP_000777806.1\|1127471_1129496_+\|AAA-family-ATPase	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
NZ_CP044513.1\|WP_000195122.1\|1125129_1126386_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.05281e-61
NZ_CP044513.1\|WP_000808789.1\|1126387_1126966_-\|NUDIX-hydrolase	gnl\|CDD\|239516	cd03424, ADPRase_NUDT5, ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, for its activity. It also contains a highly conserved 23-residue Nudix motif (GX5EX7REUXEEXGU, where U = I, L or V) which functions as a metal binding site/catalytic site. In addition to the Nudix motif, there are additional conserved amino acid residues, distal from the signature sequence, that correlate with substrate specificity. In humans, there are four distinct ADPRase activities, three putative cytosolic enzymes (ADPRase-I, -II, and -Mn) and a single mitochondrial enzyme (ADPRase-m). Human ADPRase-II is also referred to as NUDT5. It lacks the N-terminal target sequence unique to mitochondrial ADPRase. The different cytosolic types are distinguished by their specificities for substrate and specific requirement for metal ions. NUDT5 forms a homodimer.	1.26985e-42
NZ_CP044513.1\|WP_000149356.1\|1107309_1108284_+\|hypothetical-protein	gnl\|CDD\|372197	pfam12571, DUF3751, Phage tail-collar fibre protein. This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two completely conserved residues (K and W) that may be functionally important. The members are annotated as being putative phage tail or tail-collar proteins.	5.34539e-05
NZ_CP044513.1\|WP_080035936.1\|1113488_1114589_-\|adenylate/guanylate-cyclase-domain-containing-protein	gnl\|CDD\|143636	cd07302, CHD, cyclase homology domain. Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.	2.7887e-66
NZ_CP044513.1\|WP_000224797.1\|1117913_1118864_-\|fumarylacetoacetate-hydrolase-family-protein	gnl\|CDD\|376566	pfam01557, FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family. This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyzes fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerises this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.	2.72317e-55
NZ_CP044513.1\|WP_000827080.1\|1115454_1116540_-\|carboxylate--amine-ligase	gnl\|CDD\|237195	PRK12767, PRK12767, carbamoyl phosphate synthase-like protein; Provisional.	0.00568579
NZ_CP044513.1\|WP_000286980.1\|1112499_1113363_-\|alpha/beta-fold-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	3.01529e-14

>NZ_CP044513.1|WP_000224797.1|1117913_1118864_-|fumarylacetoacetate-hydrolase-family-protein
MATNYIRFKKKNSIQWGKIEENKILTLDCGDLSTKDFLEFLKKKKKYPKQKLIPIQEVSVLSPITSPCQIICQGANYRQHQIESGLDPDDKTYNLFFTKSDASLSPPIGKVIRPSHVKLLDYEIELGFVFGKSFDSTLKLNSKSIREYIAAFFMANDISARDVQLPQMQWYKGKSYRTFCPTGPYLSVLDPEDFDLLDSLELTLLVNGQIRQKDSASNLVFKPLESILELSQFCNISTGDVLLTGTPSGCALRAPGKLIQKIASILPEKVKWNLFIKGQEKRTQYLRPGDVIRSTIRSVDHRIDLGEQILNIVEAD
>NZ_CP044513.1|WP_000953879.1|1116652_1117177_-|hypothetical-protein
MLSVQFKNIQYTFHQLTDLLSSIEEKEYSKNISQLSDLSVGKHVRHCIEILENLILGIETLNISYDQRKRNPLYENSPLAARDKIFELLSKLESITENEKIELTYLVDPYKGLEEKTITNIKREFLYVQDHTIHHMAIIKLYAECFLHNVSFPEEFGVALSTIQFRSQDQNSDS
>NZ_CP044513.1|WP_000827080.1|1115454_1116540_-|carboxylate--amine-ligase
MKRLYHTINHKIILWKIWFRKLIQPEFWPSWIFYSPLVPYIFFLTIRYKGLGTICAANPGIPLGGLVGESKEQIFNNLNSKHSLKFLKLFREENRFDLIYKIILKNKFKFPYILKPDSGQRGCGIRLVKNKKEVFEYWNNTNVDLIVQEYDPGPKEAGIFYYRFPYETHGKILSITKKTFPILEGNGIDTLGNLIIRHPRFQFQWKIFQERFFKEWDTILSKGEIKRLAEAGNHCQGTLFTDGSYLITEELSKKIDNISKTFSGFFFGRYDIRYKSDKQLKQGKNFSIVELNGITSESTNLYDPDFSIWKMYKILFNQWSLLFRIGFENNNLGVPKASLVEISKAIFYFYGGNRKVNIRSD
>NZ_CP044513.1|WP_080035936.1|1113488_1114589_-|adenylate/guanylate-cyclase-domain-containing-protein
MYFISRIKSIYHSLFWPFNLIILIYLSWMWFFNGGSIGGNHYYFIPALVIATILLRKHNVWLVYLIYATSTAFLYGIEFFHRELVKSYSNDTERYLDAGGNYLFVQILTGLLIFILTRNLNIERKKSDSLLLNILPESVAEELKRNDFVVPIRYENVTVLFTDMAGFTKIAESMSPEELLSELDLFFREFDLITKKHGMEKIKTIGDSYMAAGGLPIVNNTHSIDAVLCGLEFQKFMRLKKKERENNHLPFWELRLGIHSGSVVAGVVGTKKFAYDIWGDSVNTASRMESSGIPGEVNISQETFEKIKDFFICDYRGKIKAKNKGEIDMYLVKKIREGLHDPEDELKPNQTFFKFYSQIQNGEPLS
>NZ_CP044513.1|WP_000286980.1|1112499_1113363_-|alpha/beta-fold-hydrolase
MYSKFVFFLFLFLGSYCSIPEDLKKKPKESLILLKNSGINFKEFNFTVEGKQVYGVASGCNLKNQNILIFIHGSPGGWQNYYWYLGNKTLNKKFCIFAMDRPGFGNSNPNEVIPNVEKQAFILGKTIQFFLNQIPLDKNTKIILVGHSYGAPIAARISIVFSYKIRTLVLLAAPLSSKEEEIHWYNQIADWIWVKNLLPLSLKNSNDEMFPLKSQLESLEKFWKLIPCKIILIHGKKDSLVSFHNLEFFKSIFSPSKLTTIELEKEDHFIPWTQKVFLEKIFLESIE
>NZ_CP044513.1|WP_001106691.1|1110462_1111194_+|hypothetical-protein
MNYILEKLNKQVIWINTDPNRLVGEKAWGNFKPNQHEIVYSLHYNPEVGEKFVAEIKDGVAQDFTLQKVYNKISGEERILQSWEDKIDSEIETEIEPFKDSAGNLVEYQKYTDSGWMIDQERKKESLLERNSQTFYSKLDSYRSKVGYRNTLWDSGKTYLENIQKTLTLYNKQRIISIPEWRDANDQFHSLSVEELSELLDLIELDLFNAGRILYTKKWEMEEKIRHLAPQEFLDLSIEWNLS
>NZ_CP044513.1|WP_001173236.1|1109572_1110463_+|hypothetical-protein
MALFNPAKTRIWSKSTPADGDLIDEEVDRQYENDQYLKDRIDLAESNFLATQIPLGGIIEDNLNITSTSNFKDANGQSISRISFSVLWNLVKRSITGIVPATDRISCTNHGCIEGQLVKFSFTGGGVSALVNYYVRNPTTNDFQISSTATGSILDLTSSQTGEMIINVEYGFGDGSTTYNIPDRRGIFARGAGVHGSRSKAAGGNYDGGAVGYAGQDQLFRHVHELWLNSNNNTVGGTTAYSSGAGPNTPSSASANGASPGYSIRSVISDGSNGTPRAGDENTPAYIAVKYKVRVA
>NZ_CP044513.1|WP_000257955.1|1108558_1109428_+|hypothetical-protein
MAVFNPVKTRTWSKNTPADGDLIDDEFDRQYENFQYLKDRIDSTDINLANFLIPIGSIIEDGLNLAPSINFKDANAQAISRNTFVTLWNSVHRVITGIVPTTDRISCTNHGCIEGQLVKFSFTGGGVSALVNYYVRNPTTNDFQISSTATGSILDLTSSQTGEMIINVEYGFGDGSTTYNVPDRRGIFARGAGVHGSRSKAAGGNYDGGAVGYAGQDQTQPHLHASPANGGLPFAVIGSGSSWLNTGSSNSGASSQTGIMVSDGTNGTPRTGNETTPAFIAVKYKVRVL
>NZ_CP044513.1|WP_000614736.1|1108280_1108556_+|hypothetical-protein
MIQILARETNVEFAGTGKFRIELLPVALFKTHESLLEYCHRKGYKKNGSGLDAEFTREEDLKPVRDRLKRYVDQPFKVYEKFIILEQELKE
>NZ_CP044513.1|WP_000149356.1|1107309_1108284_+|hypothetical-protein
MTHLNEVLEKYPSSIFTRDPDSTIAKKWEVELELLNEVRSVLESISGITDYRIQNGTVLDLIGKNLKQSRNGMDDFRYKIFLSIARQKRKSKGDIFSMNEIGSQILAGIGTLYEIKELCYGGIPMLLDATYTLNGEYPLSGNTKRPATIEVIFTGLVDELPVIPEFNQAIAQICPGGVKAIIRYRFEISTLGGRLYGESIRTPYLDGSWSLNGFTLLSGEKVKIRPYEIAFGIGGLSEGFPRTPGIGDTGLQNEVFRKLVEIKSDPDGNRYFQTTVKQGEMMGYGINEIGLFDEDGELLYLRTFPSKEKDHIIIYDFVIKEEFQ
>NZ_CP044513.1|WP_000793003.1|1121619_1122312_-|hypothetical-protein
MKNLILKTRLNHFRHIVHSILIAVILIFSKVINAEQLETIKIQGKSFTGRLDASGFSVVNSKGAKILSLPPEETEFVRSFRFEDFNRDGYKDIFLEDSQMGIGSEILYLFVPSAGKFREITNFFNFPNSIHIEGTKYFYSFSSLGCLGKDWISDLFIIKNNTAIQITRIEGEGCVIENGVHIYESSSQKSNSKKLIQFLPSNTFEKYKDGELGFLKQYWTKNYKKYSHNE
>NZ_CP044513.1|WP_000339870.1|1122347_1124990_-|aminopeptidase-N
MDAPNILTQTEAIERAEQVKQIGYEIHLDLKAGSSTYQGETKISFFYTGKGKGKLKIDFVTKKIEVFLLNGKDFSDYTKTDSFLDLPVNFLNVGMNEIKILYTNDYNHSGSGFHQFQDPSDGSEYLHTDFEPFEAHRMFPCFDQPDLKATYELSLIGPKDWKYVHNTLPIKEKIQKERIEIRFQKTALFSTYLFALISGPYEVWEDRYKNIPLRILCRKSLSKYMDAENIFAITKESFGFLESYFDLPYPYGKYDQIFVPEFNMGAMENVGAVTFSEHYIFRSPRIYSEYLGRANTIYHEMVHMWFGNLVTMKWWNDLWLNESFADYLSYYAMSHGKLFPDALEHFYVREEWAYREDQLSTTHPIAGSAENTLDAISNFDGISYSKGASVLRQLMYYIGEDSFRNAMRKYFQKFKNSNTIQNDFLDTMSETSGIDIRNWSKEWLDTTGVNTLLPVWKENRLFIRQLPSDTNGLLRTHALEVTVFALKENEIEKKHDGSVLSSFKTVWKDKVVVQGEETILPYSPIVKTDSSVSQNAKTKNSPILQTTSDPKNSFLSEIVVLNTNDHAYAKTYLPKDEIPLLKTSFNKLKDRFARRILWGSLWQMTRDAEISPKDFLDLVLLQGIYEEDLSVRNSHILTKASSIVTSYLKKENREEWSKKLNDLSKKFLSDPSIQEEEKIVWYRMLEGTSRTADQLSYLKDLLDGKIIIPGIKIDQERRWSILTRLSAFGEKNALVLIANEEKLDTSDLGAKKAYTAKVAFPDPKSKAAAWKEFTDPNTKYSTDMLRYGMRGFYWDHQEEILKIYEDLYFQSVIGIYKDRDSHFSSAFGNILFPDLEPHQSLVDKTNQFLKEQKEIPALLKKDLKQHRDDLIRTVKILSKQ
>NZ_CP044513.1|WP_000195122.1|1125129_1126386_-|MFS-transporter
MTQTQIKHDPFQALRISDFRSFLFGKFTVTLSISIQTTVVGWQMYHLTGSNLHVGFIGLAEAIPSISMALFSGLVIDSFPRKKIVVSALCLLSICSLLLLTLVIPNINWILRDFGVYPIYAVIFLSGIARGFLNPATAAFQTQLVDKETFPNAATWSGIAWQTSLVLGPLAGGVLIVLGLYFAYSVDLILMSLGLIMVLFVKGKPVPSKPESSESIWESLSGGWKFVSTHQIILGAISLDLFAVLFGGAVALLPSFTEKILGQSPEIFGILRSAQGVGAVLCAFFIAAKPPKKHSGWILLSCVFGFGICIILFGFSEDYRISFLCLAAAGAFDMVSVVIRHTIVQMHTPDHMRGRVSAVNHIFIGSSNEIGEFESGVTAEWLGIRRSIVAGGILTLLTVGLVGAITPRLRKMQLKDIL
>NZ_CP044513.1|WP_000808789.1|1126387_1126966_-|NUDIX-hydrolase
MKQFLPEEYDPHSNLWSKINRKDLVDTPIFKLVSWNITSPDKKISKDFFHLESLDWVNIIALTPDNKIVLVDQYRHGIHRFSLEIPGGIAEKNSLLESAQAELVEETGYVSQDWEYLGKVTGNPAILDNWCHTFIAKNAHRLHKQNLDDSEQIEIFETPIENIPKLIADHILHHGMVVAAFGMYFIKNPIRY
>NZ_CP044513.1|WP_000777806.1|1127471_1129496_+|AAA-family-ATPase
MKLSPEQEKAVRHVDGPILIFAGAGSGKTRVISNRIAHLIENAGVPAGKIVALSFTNKSAREMEERVRKMIPRQKLKGIVLSTFHSLGLNILKKHIGLLGYKHPFLLMNQNDQEGFLTTLLIANKVELKKAKVSEILGKISRIKNSGLAYREYLDSSLVESDQVANLVYDSYQKSLKEQNSLDFDDLILLPGILLREFSEVREEYHKKYQYFMVDEFQDTNQTQYIFLRALMGENRNLCVVGDDDQSIYAFRGSDLSLILNFEKDFPEANVVRLLENYRSTSVIIQGANSLIKNNLSRRSKELFSFIPGGRKIRYLERMDEKDEAAYVVDCIREEMIKDARVGSQISILFRTNFQTRPFEEELRSRSIAYKLVGGYNFFDRKEVRDMISYIRLIANTRDDASLLRILNYPKRGIGPGSISLIHEKASQMGESLYEILFRVCESPDFIPNLQKKIQSEIYNFVNLIERTKKKFSTAPKMYYAFREFIQEVGIEKEILLEEKDEKVAKARTFNLSELVNMMSYFEENHDSPEKPTLFDFINRLNLLMEDENPSDEDKEDNRVQLLTIHQSKGLEFESVYVPGMEEGILPNSRVLTEESSVDEERRLLYVAMTRARKHLCLTGAANRRKFGEQTATQASRFLTEIDPETMDWVSNDEVRQQETEDFFAELEKLKTGS
>NZ_CP044513.1|WP_000143803.1|1129498_1130149_+|hypothetical-protein
MTFNTTIITVITLFLFISGCTSSQKTVDSGLSQELVIRSKIQSIDSQLSSSQLDEKKRSSLLMEKAKLLIQIESYKEATVVLKEIQNSKEGKSLEHLDHYLGTAYLGINDTENAIVHFRKSESVDKNYESTNRKKMYAKALYQEEKYGLALGILGRASREKDFEKDILFYETVANSFMRIKEFKRCQMVLEEGLQKFPESPVLKEIQEQLSQVLPR
>NZ_CP044513.1|WP_002117205.1|1130166_1132359_+|hypothetical-protein
MARVRKKFAPGDLIRYLGSFLFFLKENRKTKITLIFFILTISIYTILVESVGYYVRNYLLDLRGVKELSRNFINKELGRAVTLGVVEYDFPNAVVFEDFRISSEEDFALNHILFRTNKIRLRLGGLWKGQPFVRGIVVKDSSINIDLQDQISGELIGYIQKINIPEIRLMNTTITISRGGEEILNALKGIDIVITKRPEGVTVSISDSLFPFPYSRYIQGTFETKFHSDEFKSNFRFQNVKAEKVRGIYSLFGKIAPSSGKISGEYEILLNGKKVSVIGKNRFTNVSGKILQELPLGLKIPDLKDADLIHEMDLKLDEIGEKQVHTFTKEENIFRITYKVNPKKLSTWEVFADWKNIRELKSIFQFPGDLEILEGGLELKGKWEETGNYGDWIKSEVSLRLSGFYWKDPFLDFRLDEAKANILTGNTLEFDAKGNLFQEPIRTRIIGKTGWKKSIRGNGTFYYPLYNDWKWELDLDRISVRNFLPVYHLWKNWIRTDIKTRQEKLIPEVRWTRTPFYKYLMEYTTFTVQWKSKSFRFGEKDLGNLTLNGKVVPFFSRLDLKGFREGNQFLEAFANFTFGQDNPYMDLRIKIAEMPWEESVNGFCGSWVIPETVTSDTTIRLFGDDFLALHNSLNVSHNVVFNRSRFQDKRSLPLNLREPFDFGYEHNLLPTLSYYRNIFWKNETADLKGYGAVEGNRVRISANGMLNDVFISRKFKEESGECKLESVGDR
>NZ_CP044513.1|WP_001193044.1|1132328_1132733_+|hypothetical-protein
MQTGIGRRQIILITFGAFLTTLLVFGIYLFIFRSPNVLIIKNSKTKIDLTGTWRVSTIVPMKQIRFINDKEAILLEESSEIKLYLMEDGEGLQLRRKGEETPIGYFLFRELKKDSWQGLWGDNLVVLKRISANN
>NZ_CP044513.1|WP_000458634.1|1133306_1133708_+|hypothetical-protein
MFCGWRLINSSTELNRLGSGVLKYDFLTQQSFFNDDLIQTPNILEEIEIFFSEELDRMSLTRVAFHLAFLNVEIIQNLVESKNSKKFDKHAHKSESNYISYQYRFDCECRILTDEFEYIEKYQCFTGLPDSFC
>NZ_CP044513.1|WP_000915471.1|1133825_1134158_-|helix-turn-helix-transcriptional-regulator
MLKLDKQDSVFKALSDPKRREILDLLSIKPKTTGEICSHFKSLDRCTVMQHLKVLEHAELLIVKKVGRIRWNYLDHVPIQEIYDRWISKYARPSLEKLTRWKNELESIID

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Crispr_ID: NZ_CP044513_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_3

2796045-2796211

Orphan

Consensus_repeat	Method
TTTTTTAAATTTCCTATTTCTTTAGGAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP044513_3

>merge|NZ_CP044513|3|2796045-2796211|CRISPRCasFinder
TGTTTTAAGGCTGCGATTTGTTTTGGTAACATCGTAAGTTGGTTTTCTTCTAAATATAATTCTTTTAGATTTTTTAAATTTCCTATTTCAGGGAGTAGCGATATAAGTTGATTTCTGCCTAAAACTAAATTACGTAAATTTTTCAAATTGCCTATCTCTTTGGGAAG

>NZ_CP044513|3|3|2796045-2796211|CRISPRCasFinder
TGTTTTAAGGCTGCGATTTGTTTTGGTA	ACATCGTAAGTTGGTTTTCTTCTAAATATAATTCTTTTAGA
TTTTTTAAATTTCCTATTTCAGGGAGTA	GCGATATAAGTTGATTTCTGCCTAAAACTAAATTACGTAAA
TTTTTCAAATTGCCTATCTCTTTGGGAAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_000993260.1\|2805491_2806991_-\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP044513.1\|WP_082271553.1\|2803633_2803834_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000788716.1\|2800716_2801784_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP044513.1\|WP_001026923.1\|2786075_2787641_-\|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl\|CDD\|350657
NZ_CP044513.1\|WP_001132139.1\|2807284_2808331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000068277.1\|2800047_2800512_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000688001.1\|2796813_2797347_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP044513.1\|WP_001158185.1\|2801840_2802935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223260
NZ_CP044513.1\|WP_000051773.1\|2793342_2793864_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NZ_CP044513.1\|WP_000371201.1\|2788715_2789426_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000465519.1\|2793915_2795052_-\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143598
NZ_CP044513.1\|WP_002091036.1\|2798952_2799816_+\|SH3-domain-containing-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001115363.1\|2785266_2786061_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236594
NZ_CP044513.1\|WP_000723318.1\|2789786_2790386_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310150
NZ_CP044513.1\|WP_000453262.1\|2780526_2780787_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_002096337.1\|2798542_2798857_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000802799.1\|2781627_2783610_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP044513.1\|WP_000986372.1\|2783844_2785239_-\|flagellar-hook-protein-FlgE	unknown	unknown	gnl\|CDD\|235557
NZ_CP044513.1\|WP_000698133.1\|2791554_2792562_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP044513.1\|WP_001050105.1\|2808431_2809700_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|380169

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_000993260.1\|2805491_2806991_-\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	6.8918e-107
NZ_CP044513.1\|WP_001026923.1\|2786075_2787641_-\|flagellar-hook-length-control-protein-FliK	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	8.83393e-13
NZ_CP044513.1\|WP_000986372.1\|2783844_2785239_-\|flagellar-hook-protein-FlgE	gnl\|CDD\|235557	PRK05682, flgE, flagellar hook protein FlgE; Validated.	1.58159e-151
NZ_CP044513.1\|WP_000688001.1\|2796813_2797347_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	7.39245e-16
NZ_CP044513.1\|WP_001158185.1\|2801840_2802935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|223260	COG0182, COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis].	6.51899e-149
NZ_CP044513.1\|WP_000051773.1\|2793342_2793864_-\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	1.59265e-08
NZ_CP044513.1\|WP_001115363.1\|2785266_2786061_-\|hypothetical-protein	gnl\|CDD\|236594	PRK09618, flgD, flagellar hook assembly protein FlgD.	3.93947e-30
NZ_CP044513.1\|WP_000723318.1\|2789786_2790386_-\|hypothetical-protein	gnl\|CDD\|310150	pfam05345, He_PIG, Putative Ig domain. This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.	0.00469651
NZ_CP044513.1\|WP_000465519.1\|2793915_2795052_-\|carbon-nitrogen-hydrolase	gnl\|CDD\|143598	cd07574, nitrilase_Rim1_like, Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases). Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	2.03923e-19
NZ_CP044513.1\|WP_000802799.1\|2781627_2783610_-\|GAF-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	3.63922e-25
NZ_CP044513.1\|WP_000788716.1\|2800716_2801784_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	5.6757e-17
NZ_CP044513.1\|WP_000698133.1\|2791554_2792562_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.25932e-15
NZ_CP044513.1\|WP_001050105.1\|2808431_2809700_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|380169	NF033161, lipo_LipL41, lipoprotein LipL41. Members of this family are lipoprotein LipL41, as described in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 but found broadly in the genus Leptospira. Close homologs that are not lipoproteins by sequence are likely defective in their reported coding region.	7.75591e-12

>NZ_CP044513.1|WP_000465519.1|2793915_2795052_-|carbon-nitrogen-hydrolase
MFFKRSYLFYFLFLILIFYGIWSYTDRSSWEQTPDSRLKRIESFGKDLKKGNLLGIQPWMYPIDYSNEINFSKKIQSYLEEASKKGYINPKTIVVFPEYLGTWLVVAGEKTSVVRSDKLEDSMRILILSNPVSFIFNFFKAQGKDKIRDALFRMKAEKMLSIYSNTFSGMAKKWGVTIVAGSILLPEPYILEGKIQIRNGALKNVSYVFLPDGRVAENSPEKIYPIEDEKSFVAAATLKNLKIIQSPMGKIGVLVCADSWYPEVYEIFKKQNVNFVVVPSYVAPDGAMSEVWKGYNGSKNPTDIRLEDVHRISEGEAWLKYALAGRILKSGATHGMNVFLRGSLWDLGSDGEIILVHRSMVRTFPKIYGASIVNLWLD
>NZ_CP044513.1|WP_000051773.1|2793342_2793864_-|hypothetical-protein
MSLFLFETFSDNFQSKHNEVTSGKWFGLTSLNLEGKPFAAFFEGSLVLKLGAEKIAEIISRYPGAKLFDPSGNNKAMKDWLQIPAEFEQDWLNLAEDALVFAEKSLSAVAVPAKKKAAPKKAAKKKAPAKKKSPAKKKAAKKKSSAKKAKMKPKAKAKKKVARKKTAAKKRKR
>NZ_CP044513.1|WP_000698133.1|2791554_2792562_+|alpha/beta-hydrolase
MKILKWILGIIGTFALFLVVTFYAETPKYEYKSVPLYSNFDSYYREKLQISRSKKVRPGNEEKLVRYSADKTDFSILYIHGFGASRAEGEEVTDQLAKDFKANLYYVRLPGHGTNLENHRDTTFEEILQDSETAFLECEKLGKKTILIGTSMGGLISTYLAAKYPEKVHALVLVSPFYDFTNPFSVIYQFSWGKDFANIVMGKIRKSTEEEKRNPASAFWYRDQYLAAVQNLSDLREFILGTDPFSKISSPTLLFYYYKNEKNQDVSASVSSMLNAFKKVNENGKANPLNKAVKVEFGNHVLFSKYMKSDKDLILKETETFIQNVFSLNKNLSHN
>NZ_CP044513.1|WP_000723318.1|2789786_2790386_-|hypothetical-protein
MKKIMLILLLFCLVFASCEDEKKDEGSITGNSIMDLLLLQEVSTPPCPGGVTMMDIPSTINAQVGTSVKSPFSIQFSAGSVNHETLMKNKNCNFSELSVTNLPAGLTLNSTTGAINGALTAISAATTVTFSAKLKANNSTPITFTKTTTVTVFAAGSLTCNTAGAALGCNNAALPYSCPNSNFCYSTYSSCKAASECGY
>NZ_CP044513.1|WP_000371201.1|2788715_2789426_-|hypothetical-protein
MDPFEKIVNRYGGWELWNRLDFVEFYFQSLSGPLPFLKGLGKTFNKHGKVRIFPKEFITEFLDYPNPGKKIIFKNGKVGIVNISENLSEFGLSNYKDSFSGLKKYRLWNPLDVSYFFGYATTQYVSIPFILKEYSVRKFELENGDFQIEAEFPSYLHTHCKKQSYRFDSEGLLIRNDYTADIVGSWAKGAHFTTHFQDIEGFPMATKRDVFVRLGSWATSIPVLSAELKPLGVYFR
>NZ_CP044513.1|WP_001026923.1|2786075_2787641_-|flagellar-hook-length-control-protein-FliK
MNISGDLSVSEFKPQQSMRSLPKMGEVAGKNSFVELMKFLQGSAQKGLEETLAEIQNTSSKAELPQPEEEDPEIIEEKKRRSINSIEEEISKEENFETTQEAPNANILPWFLVSETKTNESVDPEIESVILDELQSEIIKTNSTETLNAPESISTSELIENFFTNEVEESTKLLSEVSLKEELENLLDTEKGSLVSFENLKEIKARSTKQESEIYEKSESFEAKDSSDTFRFNEVDKKESKENIKGLSNSFKDKDFEEAKVEVSKELALDSEKWKISRDKKTDSYTNLKTAAKEEIKAVVLNQFTENSFGKSGQEQSFRSDSYSSLVKGVGTTAANGSRESGTFSKEFLPSKESNVLSKKDIQQNFQNLIRSARVQILENGRTEASIRMNPKDLGQMSLAISTDKDVVRGKLLVESDTVKQQLVAELANLKQDLKANGLELESLVIEVKEREDGFSFNADSDKNGKDSHSFQAAFGEDWNSDFKHSFYEEDELSFEENFSEPNDFPKKTDGKSEKLLDLKV
>NZ_CP044513.1|WP_001115363.1|2785266_2786061_-|hypothetical-protein
MPETTGISQQANINRYLEGDRSFNIRNHMENLEKEEKNGLKGIEIRSTVKSLGKDDFLKLLITQLSSQDPTNPVKDQDFIAQMAQFSSLEQMNNISNGIQKMGNRQSFSLVGKLVSGPDFVNGENIAGIAGALFFDGEGKTFVRVNGRSIDVEQISLISDPVVLKEQEAAYNQSQSQQSVPARTPAHSSEIGTNVSPQDAPFDVSSNAHEVTTKQKSMESSIKNQKEVEVPGTEQTPELQEKTTSEKKISDWKFPGKDKSNSYE
>NZ_CP044513.1|WP_000986372.1|2783844_2785239_-|flagellar-hook-protein-FlgE
MMRSLYSGVSGLKNHQVRMDVIGNNISNVNTHGFKTERVTFQDMISQELRGASEPKENIGGVNPQQVGLGSLIAAIDKIMTQGSLQTTGKNTDVAISGEGFFIVKDGDKQFYTRAGAFNLDKNGYYVNPANGLKVQGWNSRLDDKGNKYINSAASIEDIIIPVYSKEPARATSQIDFKSNLNSSAPAVPPDATQEEITAMINDPDPKMRRGHVTTINTFDDQGIQREFKMEFYKVRDNTWKARLSMTDSTQLSVDVSGTGGQNTQLPGNTELEFGFTPDGKLVYVSDGVDSMNSGKLNAKVSFRIPGNPAIQNFDLNLGEAGMVNGITQFSSDFTTKAVKQDGYTMGYLESFSIDNSGTITGVFSNGVRQPLARVATAVFNNPAGLDKAGDTMFSYSMNSGEPNIGEAGVQGRGKINAGLLEMSNVDLSDQFTDMIVTQRGFQANSRTITTSDQMIQEVLGLKR
>NZ_CP044513.1|WP_000802799.1|2781627_2783610_-|GAF-domain-containing-protein
MKPKFPKYIVTDLDSIVKRLGPIISRLEIEFLDFKEFFQSELFRNSSGFLNVIFYLTVSDLKKTQKEIHQQFQRNPLILSRFILNENLDYVHSEDLKIEEELIFSVLPESSSDMVFNKTFLNAFTQLQMITDQFDLQHKVNTTKYEISKLTRVGISLADEKDINKLLREIIFSAREIAIADSGSLYLVEKDELGLVRNLRFKISSMDIDTEEFLLPINKSSVAGYVAATGKILNIPDVYNLPEDSEYKFNRNFDVLSNYHTKSMLVVPMKNHRNEVVGVIQLINKKRNFNQKLTLEQMRGNDVFPFDDYSAQLVMGVAGQAAVAIQNNHLLQEIEALFEGFVTASVNAIESRDPTTSGHSFRVAVLTVGLAETVDLIREGKYKNTKFSKEQIKEIRYASLLHDFGKVGVREKVLVKSKKLEDYELELIRWRFEYIKKDIESRILQKKTDYLKKHGAVGFADYETSLEFELRVEYQKLDQMFQIVVDSNEPSILEESNFQKLEEIAKVNYSTTGGEKLSLISPYEFGFLTIKKGSLDFAERKEIESHVEHTFQFLSKIPWTGDLKMVPSIAHAHHEKLDGTGYPRGLTADSIPIQSKIMAISDIFDALTDKDRPYKRAVPIERALDILQMEARENHVDQDLLKIFIEGKVYDKLYYSGYLR
>NZ_CP044513.1|WP_000453262.1|2780526_2780787_+|hypothetical-protein
MEVKSLKRKAVCNLVFSEMYKNKTYFSNYGSKFLRTEPEKRNNLTPNNKNAIYHLLKFKITEQLFTNYYLNLNYYIIAIFLNRGLF
>NZ_CP044513.1|WP_000688001.1|2796813_2797347_-|rhodanese-like-domain-containing-protein
MKIFCLLLLNFCFCVTIMAKESDFVKTKRNPIPNRLIDYKKFQNIVNSSAEEREAKRLTEEEFLNMIQDKEVVLLDARSESRYKLRHIKGAVSLPFTEFTKESLAKVIPKINSKILIYCNNNFMGSPEAFASKAPAASLNLSTFISLKAYGYKNIYELGPLLSVDSTKLIFEGTEVQ
>NZ_CP044513.1|WP_002096337.1|2798542_2798857_+|hypothetical-protein
MSPFSHTFLRVFRAAVSSFVRKGNGKQNSQPKKYFLCPICKTSLIFFNCKLLMRLNILNEGMKFLTNPLNISAIYYFFTSIIFYISFTFHLKKMSLYKTSFKFI
>NZ_CP044513.1|WP_002091036.1|2798952_2799816_+|SH3-domain-containing-protein
MIGNNLISAEIESCFTSYPEVVVRDSPNTSGKKVRIIKQSIPLKILERTSTLEEIKIRNRKVQSNWVKISDGWIFGGLIQCIPKIFFAHPISYHEEELPFSPSDSTNWIAIYLQQESYLRKQISIDLKREHDTVVDQNENIKTGYKVNVINNPIVLIKGITFKKGNFPAITKKVPLELEFGKSYHFNFEKDNYRITSKGKPTQSSGINGYQLILHKNNEEMIIDSRIYRTEKPILVFAGDIDGDGELDFIFDLKDHYNVSNEHLYISSEKINDFFIVPVAANWNTGC
>NZ_CP044513.1|WP_000068277.1|2800047_2800512_-|hypothetical-protein
MAQNKKSALFDILKREKLEKMLKRNSSSGQSQSNEKPQTSVSENVPEKSSTEKKEPQISKIYKAIEDVKLDIRYYFLQDEYVEKLASIYIKNEGPLEKLGIDPKKYLEYARDSFDRYKQLDKKMPLEPMNKKSWDHVEKSLNELITKLLEKFSK
>NZ_CP044513.1|WP_000788716.1|2800716_2801784_-|rhomboid-family-intramembrane-serine-protease
MKNHSPSPGECGNPGQICPGLALLDSLTTIRILSNMAKRKYRNGISLFGYSIFHPINLILVVNVLVYILQLFAGGTGIIEYYFALTPFRVFHGHYWQVFSYGFLHEAYGIPFIHLFFNMYVFVMFGGLICRYISAWKFTVVYLTAILTGGITVLLAPVLNEILGIHYPMDLFQTTTLGASGGVTGILVLFGILFPETEVFLVFFRMKARYAAWIFVGGGFVADFVAVYYFHSPFVVSNSCHLGGAIGATLVAPLILKNNFGKIFPKNKDSENTKPTRSLNEDLDFQTQKNLKLLDELSKKISYSDQEDILIPLQQTNVNLCPPPTFQPEDPFCLRCDWLPNCALRKLKTSSEKIP
>NZ_CP044513.1|WP_001158185.1|2801840_2802935_+|S-methyl-5-thioribose-1-phosphate-isomerase
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVGADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>NZ_CP044513.1|WP_082271553.1|2803633_2803834_+|hypothetical-protein
MFLTICSWMAFCLCYTTFEAFLRPLYYFGEVSFKNLILSDICGVGYGSLLCFLCQSLPQFYYIRPY
>NZ_CP044513.1|WP_000993260.1|2805491_2806991_-|DUF342-domain-containing-protein
MNANEEPMNTPTPESQISPVSIESAITIVVSTDQLSATITVRPYNLKGTILSKDKLWSVIQDWGIHRDRVLTDEIRKILNLLERAAQKGDFTPIKMEVAKGVAPVPGENGWVRFYHPMSKRVKLLEDGRADFRNIDRYINVKVGEKLATKFEGIPGIPGFDVFGNIIPAPSIKKPKLVVGNHIEERNVLEEGKNLQEYFASSNGVVFATEVSITVSPELQIAGNVGLSTGNIQFDGNVIVRGDVEPGSVVECTGSLVVYGNLESNQIKVGQDLIVHGGIKGSGTEIILVTGRIQTKFIENSYLETEGDIIVEGAILNSTIDTLGSIILNGQNGNLVSSKIRTNEGISVVSLGSSAELDVTVELGFHFKNDRSFQEISRKIQMGEKEMEKILPKIQQIKHMVQRFRGNLPEDKKIAFKVVFEDYNKKLKILNMLKFKQDSLKSSRFNPGAVRLAVQKGAYPGAVIHYRRQIEKITKFQSSFMMVFEPGQEKAIMVALQTK
>NZ_CP044513.1|WP_001132139.1|2807284_2808331_-|hypothetical-protein
MPMNFFSAIRGFPFLIDYSGLKIPKQAHITEISLDLSGSVSLRTKVLENPGNSKKPVIYLQHGMSFKGIDDVRILALGNNLANRGFRVYLPELTEVKNLLIRSETISNIRASFLKIHALEKCPVSYISASFSAGMGFVALADSECQKVLNSALLIGSYSDFVKTLPFVLKNYEIESYAVNVMMYNYIHLIRSEPEGLKKYFLESALDNGLSRKEDSVQGPKVFLNLNEEDKNFLKRFLESSDFRNQLALEIKSIVPETFAKETSPAFFTDHFYRPCFLLHGDDDPVISPQESKDLRNLLLKNGNQKVSFLETSLLTHGDHRPFYSGLNEILPMAKFWGEYLNSVNLLF
>NZ_CP044513.1|WP_001050105.1|2808431_2809700_-|tetratricopeptide-repeat-protein
MNLKRIFIFFLLLCQLHCATFTGTLVNKWVKDYYESTNITGVGIGLAGDGAISVYMGVQFGLAFGLAYAAATIVALPFIFFGLLQPLKVQPVLYFPIFSNDGKDLRGLLQHVPHVIPFYIRPIVIPSHPKESIERELAKSFFSSVYFNFDFLYSFQYLNSISTSKILEHTSIEEIRNDMSRFRKLFNEDFVFISEAHLKFGECKLEKISYKEIMKFEERLLSRPVYPREKEDQEETGLMEVQVEIKTYLVDFKNQKIRSFEISETERGYNDFGQRACPDPIRAGKMALKNVGLSHTRKIFPQWKKTKLNLIRNDSDPNVQKLLEEGFQYFGRGDDENHEIFLIKPEALEVWKLALAQSGNRSEGAFANIAYYYLNNGYLEEAIDWFRKAAVANPDREKFWNLRIKDILHKREQVEVYNDLNN

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Crispr_ID: NZ_CP044513_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_4

2796321-2796624

Orphan

Consensus_repeat	Method
TTTTTTAAATTTCCTATTTCTTTAGGAA	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP044513_4

>merge|NZ_CP044513|4|2796321-2796624|CRISPRCasFinder
TTTCTTAAGTTCCCGATTTCTTGCGGTAATATTTTGAGTTGATTTCTGCTTAAATATAATTCTTTTAAGTTTTTTAAATTTCCTATTTCTTTAGGAAGTGTTTGAAGTTTATTCCATTCTATCGACAGTTCTTTTAGTTTTTTTAAATTCCCTATTTCTTTAGGAATTGTTTCAAGTTTGTTTCCATTTAAAGACAACACCTGTAAATTTTTTAAATTTCCTATTTCAGGAGGCAGAGTTGTAATTTCGTTCGCGCTTAAATATAATTTTTTTAAATTTTGTAAGTTTCCAATTTCCTTTGGAA

>NZ_CP044513|4|4|2796321-2796624|CRISPRCasFinder
TTTCTTAAGTTCCCGATTTCTTGCGGTA	ATATTTTGAGTTGATTTCTGCTTAAATATAATTCTTTTAAG
TTTTTTAAATTTCCTATTTCTTTAGGAA	GTGTTTGAAGTTTATTCCATTCTATCGACAGTTCTTTTAGT
TTTTTTAAATTCCCTATTTCTTTAGGAA	TTGTTTCAAGTTTGTTTCCATTTAAAGACAACACCTGTAAA
TTTTTTAAATTTCCTATTTCAGGAGGCA	GAGTTGTAATTTCGTTCGCGCTTAAATATAATTTTTTTAAA
TTTTGTAAGTTTCCAATTTCCTTTGGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_000993260.1\|2805491_2806991_-\|DUF342-domain-containing-protein	unknown	unknown	gnl\|CDD\|377177
NZ_CP044513.1\|WP_082271553.1\|2803633_2803834_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000788716.1\|2800716_2801784_-\|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl\|CDD\|223777
NZ_CP044513.1\|WP_001026923.1\|2786075_2787641_-\|flagellar-hook-length-control-protein-FliK	unknown	unknown	gnl\|CDD\|350657
NZ_CP044513.1\|WP_001132139.1\|2807284_2808331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000068277.1\|2800047_2800512_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000688001.1\|2796813_2797347_-\|rhodanese-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|238089
NZ_CP044513.1\|WP_001158185.1\|2801840_2802935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223260
NZ_CP044513.1\|WP_000051773.1\|2793342_2793864_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237855
NZ_CP044513.1\|WP_000371201.1\|2788715_2789426_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000465519.1\|2793915_2795052_-\|carbon-nitrogen-hydrolase	unknown	unknown	gnl\|CDD\|143598
NZ_CP044513.1\|WP_002091036.1\|2798952_2799816_+\|SH3-domain-containing-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001115363.1\|2785266_2786061_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236594
NZ_CP044513.1\|WP_000723318.1\|2789786_2790386_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310150
NZ_CP044513.1\|WP_000453262.1\|2780526_2780787_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_002096337.1\|2798542_2798857_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000802799.1\|2781627_2783610_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225116
NZ_CP044513.1\|WP_000986372.1\|2783844_2785239_-\|flagellar-hook-protein-FlgE	unknown	unknown	gnl\|CDD\|235557
NZ_CP044513.1\|WP_000698133.1\|2791554_2792562_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP044513.1\|WP_001050105.1\|2808431_2809700_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|380169

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_000993260.1\|2805491_2806991_-\|DUF342-domain-containing-protein	gnl\|CDD\|377177	pfam03961, FapA, Flagellar Assembly Protein A. Members of this family include FapA (flagellar assembly protein A), found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction.	6.8918e-107
NZ_CP044513.1\|WP_001026923.1\|2786075_2787641_-\|flagellar-hook-length-control-protein-FliK	gnl\|CDD\|350657	cd17470, T3SS_Flik_C, C-terminal domain of flagellar hook-length control protein FliK and similar domains. The flagellar hook-length control protein FliK is a soluble cytoplasmic protein that is secreted during flagellar formation. It controls hook elongation by two successive events: by determining hook length and by stopping the supply of hook protein. It contains an N-terminal domain that determines hook length and a C-terminal domain that is responsible for switching secretion from the hook protein to that of the filament protein, by interacting with FlhB, the switchable secretion gate.	8.83393e-13
NZ_CP044513.1\|WP_000986372.1\|2783844_2785239_-\|flagellar-hook-protein-FlgE	gnl\|CDD\|235557	PRK05682, flgE, flagellar hook protein FlgE; Validated.	1.58159e-151
NZ_CP044513.1\|WP_000688001.1\|2796813_2797347_-\|rhodanese-like-domain-containing-protein	gnl\|CDD\|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	7.39245e-16
NZ_CP044513.1\|WP_001158185.1\|2801840_2802935_+\|S-methyl-5-thioribose-1-phosphate-isomerase	gnl\|CDD\|223260	COG0182, COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis].	6.51899e-149
NZ_CP044513.1\|WP_000051773.1\|2793342_2793864_-\|hypothetical-protein	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	1.59265e-08
NZ_CP044513.1\|WP_001115363.1\|2785266_2786061_-\|hypothetical-protein	gnl\|CDD\|236594	PRK09618, flgD, flagellar hook assembly protein FlgD.	3.93947e-30
NZ_CP044513.1\|WP_000723318.1\|2789786_2790386_-\|hypothetical-protein	gnl\|CDD\|310150	pfam05345, He_PIG, Putative Ig domain. This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei.	0.00469651
NZ_CP044513.1\|WP_000465519.1\|2793915_2795052_-\|carbon-nitrogen-hydrolase	gnl\|CDD\|143598	cd07574, nitrilase_Rim1_like, Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases). Some members of this subgroup are implicated in post-translational modification, as they contain an N-terminal GCN5-related N-acetyltransferase (GNAT) protein RimI family domain. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 12. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	2.03923e-19
NZ_CP044513.1\|WP_000802799.1\|2781627_2783610_-\|GAF-domain-containing-protein	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	3.63922e-25
NZ_CP044513.1\|WP_000788716.1\|2800716_2801784_-\|rhomboid-family-intramembrane-serine-protease	gnl\|CDD\|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	5.6757e-17
NZ_CP044513.1\|WP_000698133.1\|2791554_2792562_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.25932e-15
NZ_CP044513.1\|WP_001050105.1\|2808431_2809700_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|380169	NF033161, lipo_LipL41, lipoprotein LipL41. Members of this family are lipoprotein LipL41, as described in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 but found broadly in the genus Leptospira. Close homologs that are not lipoproteins by sequence are likely defective in their reported coding region.	7.75591e-12

>NZ_CP044513.1|WP_000465519.1|2793915_2795052_-|carbon-nitrogen-hydrolase
MFFKRSYLFYFLFLILIFYGIWSYTDRSSWEQTPDSRLKRIESFGKDLKKGNLLGIQPWMYPIDYSNEINFSKKIQSYLEEASKKGYINPKTIVVFPEYLGTWLVVAGEKTSVVRSDKLEDSMRILILSNPVSFIFNFFKAQGKDKIRDALFRMKAEKMLSIYSNTFSGMAKKWGVTIVAGSILLPEPYILEGKIQIRNGALKNVSYVFLPDGRVAENSPEKIYPIEDEKSFVAAATLKNLKIIQSPMGKIGVLVCADSWYPEVYEIFKKQNVNFVVVPSYVAPDGAMSEVWKGYNGSKNPTDIRLEDVHRISEGEAWLKYALAGRILKSGATHGMNVFLRGSLWDLGSDGEIILVHRSMVRTFPKIYGASIVNLWLD
>NZ_CP044513.1|WP_000051773.1|2793342_2793864_-|hypothetical-protein
MSLFLFETFSDNFQSKHNEVTSGKWFGLTSLNLEGKPFAAFFEGSLVLKLGAEKIAEIISRYPGAKLFDPSGNNKAMKDWLQIPAEFEQDWLNLAEDALVFAEKSLSAVAVPAKKKAAPKKAAKKKAPAKKKSPAKKKAAKKKSSAKKAKMKPKAKAKKKVARKKTAAKKRKR
>NZ_CP044513.1|WP_000698133.1|2791554_2792562_+|alpha/beta-hydrolase
MKILKWILGIIGTFALFLVVTFYAETPKYEYKSVPLYSNFDSYYREKLQISRSKKVRPGNEEKLVRYSADKTDFSILYIHGFGASRAEGEEVTDQLAKDFKANLYYVRLPGHGTNLENHRDTTFEEILQDSETAFLECEKLGKKTILIGTSMGGLISTYLAAKYPEKVHALVLVSPFYDFTNPFSVIYQFSWGKDFANIVMGKIRKSTEEEKRNPASAFWYRDQYLAAVQNLSDLREFILGTDPFSKISSPTLLFYYYKNEKNQDVSASVSSMLNAFKKVNENGKANPLNKAVKVEFGNHVLFSKYMKSDKDLILKETETFIQNVFSLNKNLSHN
>NZ_CP044513.1|WP_000723318.1|2789786_2790386_-|hypothetical-protein
MKKIMLILLLFCLVFASCEDEKKDEGSITGNSIMDLLLLQEVSTPPCPGGVTMMDIPSTINAQVGTSVKSPFSIQFSAGSVNHETLMKNKNCNFSELSVTNLPAGLTLNSTTGAINGALTAISAATTVTFSAKLKANNSTPITFTKTTTVTVFAAGSLTCNTAGAALGCNNAALPYSCPNSNFCYSTYSSCKAASECGY
>NZ_CP044513.1|WP_000371201.1|2788715_2789426_-|hypothetical-protein
MDPFEKIVNRYGGWELWNRLDFVEFYFQSLSGPLPFLKGLGKTFNKHGKVRIFPKEFITEFLDYPNPGKKIIFKNGKVGIVNISENLSEFGLSNYKDSFSGLKKYRLWNPLDVSYFFGYATTQYVSIPFILKEYSVRKFELENGDFQIEAEFPSYLHTHCKKQSYRFDSEGLLIRNDYTADIVGSWAKGAHFTTHFQDIEGFPMATKRDVFVRLGSWATSIPVLSAELKPLGVYFR
>NZ_CP044513.1|WP_001026923.1|2786075_2787641_-|flagellar-hook-length-control-protein-FliK
MNISGDLSVSEFKPQQSMRSLPKMGEVAGKNSFVELMKFLQGSAQKGLEETLAEIQNTSSKAELPQPEEEDPEIIEEKKRRSINSIEEEISKEENFETTQEAPNANILPWFLVSETKTNESVDPEIESVILDELQSEIIKTNSTETLNAPESISTSELIENFFTNEVEESTKLLSEVSLKEELENLLDTEKGSLVSFENLKEIKARSTKQESEIYEKSESFEAKDSSDTFRFNEVDKKESKENIKGLSNSFKDKDFEEAKVEVSKELALDSEKWKISRDKKTDSYTNLKTAAKEEIKAVVLNQFTENSFGKSGQEQSFRSDSYSSLVKGVGTTAANGSRESGTFSKEFLPSKESNVLSKKDIQQNFQNLIRSARVQILENGRTEASIRMNPKDLGQMSLAISTDKDVVRGKLLVESDTVKQQLVAELANLKQDLKANGLELESLVIEVKEREDGFSFNADSDKNGKDSHSFQAAFGEDWNSDFKHSFYEEDELSFEENFSEPNDFPKKTDGKSEKLLDLKV
>NZ_CP044513.1|WP_001115363.1|2785266_2786061_-|hypothetical-protein
MPETTGISQQANINRYLEGDRSFNIRNHMENLEKEEKNGLKGIEIRSTVKSLGKDDFLKLLITQLSSQDPTNPVKDQDFIAQMAQFSSLEQMNNISNGIQKMGNRQSFSLVGKLVSGPDFVNGENIAGIAGALFFDGEGKTFVRVNGRSIDVEQISLISDPVVLKEQEAAYNQSQSQQSVPARTPAHSSEIGTNVSPQDAPFDVSSNAHEVTTKQKSMESSIKNQKEVEVPGTEQTPELQEKTTSEKKISDWKFPGKDKSNSYE
>NZ_CP044513.1|WP_000986372.1|2783844_2785239_-|flagellar-hook-protein-FlgE
MMRSLYSGVSGLKNHQVRMDVIGNNISNVNTHGFKTERVTFQDMISQELRGASEPKENIGGVNPQQVGLGSLIAAIDKIMTQGSLQTTGKNTDVAISGEGFFIVKDGDKQFYTRAGAFNLDKNGYYVNPANGLKVQGWNSRLDDKGNKYINSAASIEDIIIPVYSKEPARATSQIDFKSNLNSSAPAVPPDATQEEITAMINDPDPKMRRGHVTTINTFDDQGIQREFKMEFYKVRDNTWKARLSMTDSTQLSVDVSGTGGQNTQLPGNTELEFGFTPDGKLVYVSDGVDSMNSGKLNAKVSFRIPGNPAIQNFDLNLGEAGMVNGITQFSSDFTTKAVKQDGYTMGYLESFSIDNSGTITGVFSNGVRQPLARVATAVFNNPAGLDKAGDTMFSYSMNSGEPNIGEAGVQGRGKINAGLLEMSNVDLSDQFTDMIVTQRGFQANSRTITTSDQMIQEVLGLKR
>NZ_CP044513.1|WP_000802799.1|2781627_2783610_-|GAF-domain-containing-protein
MKPKFPKYIVTDLDSIVKRLGPIISRLEIEFLDFKEFFQSELFRNSSGFLNVIFYLTVSDLKKTQKEIHQQFQRNPLILSRFILNENLDYVHSEDLKIEEELIFSVLPESSSDMVFNKTFLNAFTQLQMITDQFDLQHKVNTTKYEISKLTRVGISLADEKDINKLLREIIFSAREIAIADSGSLYLVEKDELGLVRNLRFKISSMDIDTEEFLLPINKSSVAGYVAATGKILNIPDVYNLPEDSEYKFNRNFDVLSNYHTKSMLVVPMKNHRNEVVGVIQLINKKRNFNQKLTLEQMRGNDVFPFDDYSAQLVMGVAGQAAVAIQNNHLLQEIEALFEGFVTASVNAIESRDPTTSGHSFRVAVLTVGLAETVDLIREGKYKNTKFSKEQIKEIRYASLLHDFGKVGVREKVLVKSKKLEDYELELIRWRFEYIKKDIESRILQKKTDYLKKHGAVGFADYETSLEFELRVEYQKLDQMFQIVVDSNEPSILEESNFQKLEEIAKVNYSTTGGEKLSLISPYEFGFLTIKKGSLDFAERKEIESHVEHTFQFLSKIPWTGDLKMVPSIAHAHHEKLDGTGYPRGLTADSIPIQSKIMAISDIFDALTDKDRPYKRAVPIERALDILQMEARENHVDQDLLKIFIEGKVYDKLYYSGYLR
>NZ_CP044513.1|WP_000453262.1|2780526_2780787_+|hypothetical-protein
MEVKSLKRKAVCNLVFSEMYKNKTYFSNYGSKFLRTEPEKRNNLTPNNKNAIYHLLKFKITEQLFTNYYLNLNYYIIAIFLNRGLF
>NZ_CP044513.1|WP_000688001.1|2796813_2797347_-|rhodanese-like-domain-containing-protein
MKIFCLLLLNFCFCVTIMAKESDFVKTKRNPIPNRLIDYKKFQNIVNSSAEEREAKRLTEEEFLNMIQDKEVVLLDARSESRYKLRHIKGAVSLPFTEFTKESLAKVIPKINSKILIYCNNNFMGSPEAFASKAPAASLNLSTFISLKAYGYKNIYELGPLLSVDSTKLIFEGTEVQ
>NZ_CP044513.1|WP_002096337.1|2798542_2798857_+|hypothetical-protein
MSPFSHTFLRVFRAAVSSFVRKGNGKQNSQPKKYFLCPICKTSLIFFNCKLLMRLNILNEGMKFLTNPLNISAIYYFFTSIIFYISFTFHLKKMSLYKTSFKFI
>NZ_CP044513.1|WP_002091036.1|2798952_2799816_+|SH3-domain-containing-protein
MIGNNLISAEIESCFTSYPEVVVRDSPNTSGKKVRIIKQSIPLKILERTSTLEEIKIRNRKVQSNWVKISDGWIFGGLIQCIPKIFFAHPISYHEEELPFSPSDSTNWIAIYLQQESYLRKQISIDLKREHDTVVDQNENIKTGYKVNVINNPIVLIKGITFKKGNFPAITKKVPLELEFGKSYHFNFEKDNYRITSKGKPTQSSGINGYQLILHKNNEEMIIDSRIYRTEKPILVFAGDIDGDGELDFIFDLKDHYNVSNEHLYISSEKINDFFIVPVAANWNTGC
>NZ_CP044513.1|WP_000068277.1|2800047_2800512_-|hypothetical-protein
MAQNKKSALFDILKREKLEKMLKRNSSSGQSQSNEKPQTSVSENVPEKSSTEKKEPQISKIYKAIEDVKLDIRYYFLQDEYVEKLASIYIKNEGPLEKLGIDPKKYLEYARDSFDRYKQLDKKMPLEPMNKKSWDHVEKSLNELITKLLEKFSK
>NZ_CP044513.1|WP_000788716.1|2800716_2801784_-|rhomboid-family-intramembrane-serine-protease
MKNHSPSPGECGNPGQICPGLALLDSLTTIRILSNMAKRKYRNGISLFGYSIFHPINLILVVNVLVYILQLFAGGTGIIEYYFALTPFRVFHGHYWQVFSYGFLHEAYGIPFIHLFFNMYVFVMFGGLICRYISAWKFTVVYLTAILTGGITVLLAPVLNEILGIHYPMDLFQTTTLGASGGVTGILVLFGILFPETEVFLVFFRMKARYAAWIFVGGGFVADFVAVYYFHSPFVVSNSCHLGGAIGATLVAPLILKNNFGKIFPKNKDSENTKPTRSLNEDLDFQTQKNLKLLDELSKKISYSDQEDILIPLQQTNVNLCPPPTFQPEDPFCLRCDWLPNCALRKLKTSSEKIP
>NZ_CP044513.1|WP_001158185.1|2801840_2802935_+|S-methyl-5-thioribose-1-phosphate-isomerase
MQESGLKPILWKNKELILLDQRVLPGTTSYITAKTLEDCIFAIREMVVRGAPAIAITGAFGITLYWNSLVSKPSFSELKLKLSELLESRPTAVNLRLAIEEFSSRFPESNYSSFSLEEIQKGAEELALFMLSEDLENNLTLSKYALSLFPKQPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELQEEKIQSFLITDNMAGWVMSSRKIDAVIVGADRIASNGDTANKIGTYPLAIVAKHHGVPFYVAATAKSMDFRIPNGSYIPIEMRKEEEITSFGFLKDSDGKPLLKEGVIAPKGMKALNPSFDVTPASLITGIITEKGIVSPVTEENLKKIFQSI
>NZ_CP044513.1|WP_082271553.1|2803633_2803834_+|hypothetical-protein
MFLTICSWMAFCLCYTTFEAFLRPLYYFGEVSFKNLILSDICGVGYGSLLCFLCQSLPQFYYIRPY
>NZ_CP044513.1|WP_000993260.1|2805491_2806991_-|DUF342-domain-containing-protein
MNANEEPMNTPTPESQISPVSIESAITIVVSTDQLSATITVRPYNLKGTILSKDKLWSVIQDWGIHRDRVLTDEIRKILNLLERAAQKGDFTPIKMEVAKGVAPVPGENGWVRFYHPMSKRVKLLEDGRADFRNIDRYINVKVGEKLATKFEGIPGIPGFDVFGNIIPAPSIKKPKLVVGNHIEERNVLEEGKNLQEYFASSNGVVFATEVSITVSPELQIAGNVGLSTGNIQFDGNVIVRGDVEPGSVVECTGSLVVYGNLESNQIKVGQDLIVHGGIKGSGTEIILVTGRIQTKFIENSYLETEGDIIVEGAILNSTIDTLGSIILNGQNGNLVSSKIRTNEGISVVSLGSSAELDVTVELGFHFKNDRSFQEISRKIQMGEKEMEKILPKIQQIKHMVQRFRGNLPEDKKIAFKVVFEDYNKKLKILNMLKFKQDSLKSSRFNPGAVRLAVQKGAYPGAVIHYRRQIEKITKFQSSFMMVFEPGQEKAIMVALQTK
>NZ_CP044513.1|WP_001132139.1|2807284_2808331_-|hypothetical-protein
MPMNFFSAIRGFPFLIDYSGLKIPKQAHITEISLDLSGSVSLRTKVLENPGNSKKPVIYLQHGMSFKGIDDVRILALGNNLANRGFRVYLPELTEVKNLLIRSETISNIRASFLKIHALEKCPVSYISASFSAGMGFVALADSECQKVLNSALLIGSYSDFVKTLPFVLKNYEIESYAVNVMMYNYIHLIRSEPEGLKKYFLESALDNGLSRKEDSVQGPKVFLNLNEEDKNFLKRFLESSDFRNQLALEIKSIVPETFAKETSPAFFTDHFYRPCFLLHGDDDPVISPQESKDLRNLLLKNGNQKVSFLETSLLTHGDHRPFYSGLNEILPMAKFWGEYLNSVNLLF
>NZ_CP044513.1|WP_001050105.1|2808431_2809700_-|tetratricopeptide-repeat-protein
MNLKRIFIFFLLLCQLHCATFTGTLVNKWVKDYYESTNITGVGIGLAGDGAISVYMGVQFGLAFGLAYAAATIVALPFIFFGLLQPLKVQPVLYFPIFSNDGKDLRGLLQHVPHVIPFYIRPIVIPSHPKESIERELAKSFFSSVYFNFDFLYSFQYLNSISTSKILEHTSIEEIRNDMSRFRKLFNEDFVFISEAHLKFGECKLEKISYKEIMKFEERLLSRPVYPREKEDQEETGLMEVQVEIKTYLVDFKNQKIRSFEISETERGYNDFGQRACPDPIRAGKMALKNVGLSHTRKIFPQWKKTKLNLIRNDSDPNVQKLLEEGFQYFGRGDDENHEIFLIKPEALEVWKLALAQSGNRSEGAFANIAYYYLNNGYLEEAIDWFRKAAVANPDREKFWNLRIKDILHKREQVEVYNDLNN

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Crispr_ID: NZ_CP044513_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_5

3121027-3121926

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT

12 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP044513_5

>merge|NZ_CP044513|5|3121027-3121926|PILER-CR,CRISPRCasFinder,CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTTCCCGAAATACCTGAATGATTTTTTCTGTATAAACTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGTTAGATTTAAGTCTCTTGGTTGAACTTCAATCGGTGCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGATCTCAGTCCGTTGATAAACTCAATTACGGAATTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCAAGAGAAAAAGGATAAAGACGGAAACCGGTTTTTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTATTTCACCTTTTACTTTATGAGAAATTTCGAATCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTCCTGGGCCTGGTATGTTTATATTATCAGGGGATGCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACAGTTGGCACTTTTCGCGGGAGCTGGTGGAGGCATACTTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGCTGCTGACACTGTTATTATACCAGTAATACCGGAGCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACATCATGCGAATCCGGTGGGAACGTTGCTGGTTTATCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCTAAGTTCGATTTTTCAATCTTTACAAACGAGGCTCTTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCCACGAAACAGATACAAAGCCTTCTATTTTTCCCTCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACCCACGAAACAGATACAAAGCCTTCTATTTTTCCCTCTGAATATAACTTTGATGCCGGTAGGCGGTTTAGATG

>NZ_CP044513|5|1|3121027-3121854|PILER-CR
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTCCCGAAATACCTGAATGATTTTTTCTGTATAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GTTAGATTTAAGTCTCTTGGTTGAACTTCAATCGGTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GATCTCAGTCCGTTGATAAACTCAATTACGGAATT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAGAGAAAAAGGATAAAGACGGAAACCGGTTTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATTTCACCTTTTACTTTATGAGAAATTTCGAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTCCTGGGCCTGGTATGTTTATATTATCAGGGGATG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	AGTTGGCACTTTTCGCGGGAGCTGGTGGAGGCATACTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCTGCTGACACTGTTATTATACCAGTAATACCGGAGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ATCATGCGAATCCGGTGGGAACGTTGCTGGTTTAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAAGTTCGATTTTTCAATCTTTACAAACGAGGCTCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCACGAAACAGATACAAAGCCTTCTATTTTTCCCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC

>NZ_CP044513|5|5|3121027-3121926|CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTCCCGAAATACCTGAATGATTTTTTCTGTATAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GTTAGATTTAAGTCTCTTGGTTGAACTTCAATCGGTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GATCTCAGTCCGTTGATAAACTCAATTACGGAATT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAGAGAAAAAGGATAAAGACGGAAACCGGTTTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATTTCACCTTTTACTTTATGAGAAATTTCGAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTCCTGGGCCTGGTATGTTTATATTATCAGGGGATG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	AGTTGGCACTTTTCGCGGGAGCTGGTGGAGGCATACTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCTGCTGACACTGTTATTATACCAGTAATACCGGAGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ATCATGCGAATCCGGTGGGAACGTTGCTGGTTTAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAAGTTCGATTTTTCAATCTTTACAAACGAGGCTCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCACGAAACAGATACAAAGCCTTCTATTTTTCCCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCACGAAACAGATACAAAGCCTTCTATTTTTCCCT
CTGAATATAACTTTGATGCCGGTAGGCGGTTTAGATG

>NZ_CP044513|5|1|3121027-3121925|CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTTCCCGAAATACCTGAATGATTTTTTCTGTATAAA
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GTTAGATTTAAGTCTCTTGGTTGAACTTCAATCGGTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GATCTCAGTCCGTTGATAAACTCAATTACGGAATT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CAAGAGAAAAAGGATAAAGACGGAAACCGGTTTTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TATTTCACCTTTTACTTTATGAGAAATTTCGAAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTCCTGGGCCTGGTATGTTTATATTATCAGGGGATG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	AGTTGGCACTTTTCGCGGGAGCTGGTGGAGGCATACTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GCTGCTGACACTGTTATTATACCAGTAATACCGGAGC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	ATCATGCGAATCCGGTGGGAACGTTGCTGGTTTAT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CTAAGTTCGATTTTTCAATCTTTACAAACGAGGCTCTT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCACGAAACAGATACAAAGCCTTCTATTTTTCCCT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CCACGAAACAGATACAAAGCCTTCTATTTTTCCCT
CTGAATATAACTTTGATGCCGGTAGGCGGTTTAGAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP044513.1\|WP_025183357.1\|3130959_3131166_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP044513.1\|WP_002100227.1\|3130610_3130802_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP044513.1\|WP_000110275.1\|3120780_3120984_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341150
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP044513.1\|WP_000451409.1\|3116184_3116397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP044513.1\|WP_001072141.1\|3115614_3116001_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001110344.1\|3114720_3115272_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.93224e-135
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.15094e-100
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.00101694
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.5023e-83
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.5418e-164
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.49623e-28
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	gnl\|CDD\|341150	cd17261, RMtype1_S_EcoKI-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) TRD2-CR2, Escherichia coli A58 S subunit (S.EcoEI) TRD2-CR2, and Aminomonas paucivorans S subunit (S.Apa12260I) TRD2-CR2. Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) recognizes 5'... AACNNNNNNGTGC ... 3', Escherichia coli A58 S subunit (S.EcoEI) recognizes 5'... GAGNNNNNNNATGC ... 3', and Aminomonas paucivorans S subunit (S.Apa12260I) recognizes 5'... GCCNNNNNCTCC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoKI-TRD1 recognizes AAC/GTT and S.EcoKI-TRD2 recognizes GCAC/GTGC, S.EcoEI TRD1 recognizes GAG/CTC and S.EcoEI TRD2 recognizes GCAT/ATGC, and S.Apa12260I TRD1 recognizes GCC/GGC and S.Apa12260I TRD2 recognizes GGAG/CTCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	5.35967e-53
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.40487e-09
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	4.95649e-101
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.82035e-156
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	5.2807e-44
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	2.69731e-18
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0

>NZ_CP044513.1|WP_000110275.1|3120780_3120984_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP044513.1|WP_000683528.1|3120378_3120660_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP044513.1|WP_002063811.1|3118753_3120379_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP044513.1|WP_080030596.1|3118065_3118275_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVPQDKIQLGIPIIGLLKPHKTLYNRLIGSANI
>NZ_CP044513.1|WP_000578383.1|3116658_3117534_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGKYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEKWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP044513.1|WP_000451409.1|3116184_3116397_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKFWTTALGNINKL
>NZ_CP044513.1|WP_001072141.1|3115614_3116001_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP044513.1|WP_001110344.1|3114720_3115272_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP044513.1|WP_000590871.1|3112366_3113863_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVLEECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP044513.1|WP_001060162.1|3111157_3111994_+|aldo/keto-reductase
MNNKENPLKQMIMLNNGISMPILGLGVWKTKSGKECKEAVLNALEAGYRHIDTARIYDNEVDVGQAIRESRIPRKEIFITTKLWNADQGSDKTRKALENSLDRLGIDFVDLYLIHFPVTSKRMDSWKELEKLYHDKLCKAIGVSNYTIIHLTELLKNSQITPAVNQVEFHPFLNQIHLLEYCKKHKIQLEAYSPLAHGQKIEDPTIAKIAQKYDKTPAQILIRWAIEQKIVVIPKSIKKERIIENSKVFDFAISEEDMKILNSLDEDFRTCWDPSEVV
>NZ_CP044513.1|WP_001216977.1|3123450_3123846_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP044513.1|WP_000026910.1|3124126_3124759_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDPLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP044513.1|WP_000601694.1|3124755_3127008_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWIRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNAKIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSNIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSPNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGTFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEDIAQALIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWN
>NZ_CP044513.1|WP_000098768.1|3127015_3128902_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVKEKEIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEQEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP044513.1|WP_000052101.1|3128966_3129806_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGFDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP044513.1|WP_000371336.1|3129826_3130450_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHREFFSDCEMCFAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPIKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP044513.1|WP_002100227.1|3130610_3130802_+|hypothetical-protein
MVRRSGSSLSMPLGGLDEEKILFWPKLFAKTCKQIKCRNYCFSEKQYFVQINVGTPTLKKEGF
>NZ_CP044513.1|WP_025183357.1|3130959_3131166_+|hypothetical-protein
MPLGDLDEEKICFGPNCFAKVCKRIKCGNYYFSEKRCFVQRNVGTPTLKKRISKFLRLNLQRPDAVRR
>NZ_CP044513.1|WP_000872844.1|3131366_3133268_-|hypothetical-protein
MKYDLLGLYIEEFSIRNKNLENQNVYSVTNSEGFIRSTDFFNKVVFSKDLANYKVVLPNYFAYNPSRLNVGSIDFLSSSDGVIVSPLYVIFKCNDLLFSEYLKRYLKSKTGQMQIKSKTKGAVRDTVSFSSLAEMRIPIPPLADQIHIAHILSQAEALIAQRKESIRLLDELVKSKFLEMFGDPVKNEKGWEVKRLKDVIYGIDSGWSPVCEDYSRSIESEKAILKLGSVTKCKFDPTANKKLPEELEEKKLIEVKDGDVLFTRKNTKELVAAACYVFKTPCNLFLSDLIFRLNYNSDLLNGIYLSNLITEEKYRKQIQSLATGSAGSMPNISKEKLMNFYTLVPPISIQNKFAEFVENIQLQKIQYQRSLIDLETLYSSLSQKAFNGELTANQKSSSTVSAPWLARETSLHVIATDSNKERTTLQKIDKIKAAFSSKKEEQSFLKRKILGSYIINQSLEDSQFGDVKFEKLLHLSEYLILKRNFGQHYVQKVAGPYDNKFTILFFQQIEKDRWFRRIKEGKQFHFQKGEKHESSTKIYNYFSEEELGFVQSLIQLFKKANYEKVEVVSTLYAVWNNRIIKGEPIEDNLLKEDFLNWDSQKTKYKDRLDNAIVWMREKNLVPDGWGPLIEKTK
>NZ_CP044513.1|WP_000429183.1|3133264_3133882_-|Fic-family-protein
MENLERYINDDELSDTDVLIKMAVIHYQFESIHPFYDGNGRTGRILNILYLVLKDLLILLILYLNRYIIQNKTQYYKFLQGVRDKQDWESWILFILIGVEGTFIQTIDMIQSIKQVMMDYKHRVRSSCKFYSQDLINNLFYHSYTKIEFIEKDLGVGRLTAVKYLEELRRLGFLKKQKWGRSNDYINLGLYKILVRREWSRIINI

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Crispr_ID: NZ_CP044513_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_7

3122419-3122526

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP044513_7

>merge|NZ_CP044513|7|3122419-3122526|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGGTAGGCGTTGAGCACAGCGTTTCTAATTTTTCGTCTACAGTCACTTTACGCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP044513|7|7|3122419-3122526|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGGTAGGCGTTGAGCAC	AGCGTTTCTAATTTTTCGTCTACAGTCACTTTACG
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP044513.1\|WP_025183357.1\|3130959_3131166_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP044513.1\|WP_002100227.1\|3130610_3130802_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP044513.1\|WP_000110275.1\|3120780_3120984_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341150
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP044513.1\|WP_000451409.1\|3116184_3116397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP044513.1\|WP_001072141.1\|3115614_3116001_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001110344.1\|3114720_3115272_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.93224e-135
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.15094e-100
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.00101694
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.5023e-83
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.5418e-164
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.49623e-28
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	gnl\|CDD\|341150	cd17261, RMtype1_S_EcoKI-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) TRD2-CR2, Escherichia coli A58 S subunit (S.EcoEI) TRD2-CR2, and Aminomonas paucivorans S subunit (S.Apa12260I) TRD2-CR2. Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) recognizes 5'... AACNNNNNNGTGC ... 3', Escherichia coli A58 S subunit (S.EcoEI) recognizes 5'... GAGNNNNNNNATGC ... 3', and Aminomonas paucivorans S subunit (S.Apa12260I) recognizes 5'... GCCNNNNNCTCC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoKI-TRD1 recognizes AAC/GTT and S.EcoKI-TRD2 recognizes GCAC/GTGC, S.EcoEI TRD1 recognizes GAG/CTC and S.EcoEI TRD2 recognizes GCAT/ATGC, and S.Apa12260I TRD1 recognizes GCC/GGC and S.Apa12260I TRD2 recognizes GGAG/CTCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	5.35967e-53
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.40487e-09
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	4.95649e-101
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.82035e-156
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	5.2807e-44
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	2.69731e-18
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0

>NZ_CP044513.1|WP_000110275.1|3120780_3120984_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP044513.1|WP_000683528.1|3120378_3120660_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP044513.1|WP_002063811.1|3118753_3120379_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP044513.1|WP_080030596.1|3118065_3118275_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVPQDKIQLGIPIIGLLKPHKTLYNRLIGSANI
>NZ_CP044513.1|WP_000578383.1|3116658_3117534_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGKYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEKWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP044513.1|WP_000451409.1|3116184_3116397_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKFWTTALGNINKL
>NZ_CP044513.1|WP_001072141.1|3115614_3116001_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP044513.1|WP_001110344.1|3114720_3115272_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP044513.1|WP_000590871.1|3112366_3113863_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVLEECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP044513.1|WP_001060162.1|3111157_3111994_+|aldo/keto-reductase
MNNKENPLKQMIMLNNGISMPILGLGVWKTKSGKECKEAVLNALEAGYRHIDTARIYDNEVDVGQAIRESRIPRKEIFITTKLWNADQGSDKTRKALENSLDRLGIDFVDLYLIHFPVTSKRMDSWKELEKLYHDKLCKAIGVSNYTIIHLTELLKNSQITPAVNQVEFHPFLNQIHLLEYCKKHKIQLEAYSPLAHGQKIEDPTIAKIAQKYDKTPAQILIRWAIEQKIVVIPKSIKKERIIENSKVFDFAISEEDMKILNSLDEDFRTCWDPSEVV
>NZ_CP044513.1|WP_001216977.1|3123450_3123846_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP044513.1|WP_000026910.1|3124126_3124759_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDPLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP044513.1|WP_000601694.1|3124755_3127008_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWIRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNAKIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSNIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSPNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGTFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEDIAQALIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWN
>NZ_CP044513.1|WP_000098768.1|3127015_3128902_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVKEKEIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEQEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP044513.1|WP_000052101.1|3128966_3129806_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGFDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP044513.1|WP_000371336.1|3129826_3130450_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHREFFSDCEMCFAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPIKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP044513.1|WP_002100227.1|3130610_3130802_+|hypothetical-protein
MVRRSGSSLSMPLGGLDEEKILFWPKLFAKTCKQIKCRNYCFSEKQYFVQINVGTPTLKKEGF
>NZ_CP044513.1|WP_025183357.1|3130959_3131166_+|hypothetical-protein
MPLGDLDEEKICFGPNCFAKVCKRIKCGNYYFSEKRCFVQRNVGTPTLKKRISKFLRLNLQRPDAVRR
>NZ_CP044513.1|WP_000872844.1|3131366_3133268_-|hypothetical-protein
MKYDLLGLYIEEFSIRNKNLENQNVYSVTNSEGFIRSTDFFNKVVFSKDLANYKVVLPNYFAYNPSRLNVGSIDFLSSSDGVIVSPLYVIFKCNDLLFSEYLKRYLKSKTGQMQIKSKTKGAVRDTVSFSSLAEMRIPIPPLADQIHIAHILSQAEALIAQRKESIRLLDELVKSKFLEMFGDPVKNEKGWEVKRLKDVIYGIDSGWSPVCEDYSRSIESEKAILKLGSVTKCKFDPTANKKLPEELEEKKLIEVKDGDVLFTRKNTKELVAAACYVFKTPCNLFLSDLIFRLNYNSDLLNGIYLSNLITEEKYRKQIQSLATGSAGSMPNISKEKLMNFYTLVPPISIQNKFAEFVENIQLQKIQYQRSLIDLETLYSSLSQKAFNGELTANQKSSSTVSAPWLARETSLHVIATDSNKERTTLQKIDKIKAAFSSKKEEQSFLKRKILGSYIINQSLEDSQFGDVKFEKLLHLSEYLILKRNFGQHYVQKVAGPYDNKFTILFFQQIEKDRWFRRIKEGKQFHFQKGEKHESSTKIYNYFSEEELGFVQSLIQLFKKANYEKVEVVSTLYAVWNNRIIKGEPIEDNLLKEDFLNWDSQKTKYKDRLDNAIVWMREKNLVPDGWGPLIEKTK
>NZ_CP044513.1|WP_000429183.1|3133264_3133882_-|Fic-family-protein
MENLERYINDDELSDTDVLIKMAVIHYQFESIHPFYDGNGRTGRILNILYLVLKDLLILLILYLNRYIIQNKTQYYKFLQGVRDKQDWESWILFILIGVEGTFIQTIDMIQSIKQVMMDYKHRVRSSCKFYSQDLINNLFYHSYTKIEFIEKDLGVGRLTAVKYLEELRRLGFLKKQKWGRSNDYINLGLYKILVRREWSRIINI

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Crispr_ID: NZ_CP044513_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_9

3123162-3123269

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

1 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP044513_9

>merge|NZ_CP044513|9|3123162-3123269|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGGTAGGCGTTGAGCACAGTTGACTCTGCAAAACTTTTGCCTCAAATTCAGGACTGAATATAACTTTGATGCCGGTAGGCGGTTTAGAA

>NZ_CP044513|9|9|3123162-3123269|CRISPRCasFinder
CTTACAAAAATCAGGATGCCGGTAGGCGTTGAGCAC	AGTTGACTCTGCAAAACTTTTGCCTCAAATTCAGGA
CTGAATATAACTTTGATGCCGGTAGGCGGTTTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP044513.1\|WP_025183357.1\|3130959_3131166_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP044513.1\|WP_002100227.1\|3130610_3130802_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP044513.1\|WP_000110275.1\|3120780_3120984_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341150
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP044513.1\|WP_000451409.1\|3116184_3116397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP044513.1\|WP_001072141.1\|3115614_3116001_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001110344.1\|3114720_3115272_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.93224e-135
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.15094e-100
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.00101694
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.5023e-83
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.5418e-164
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.49623e-28
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	gnl\|CDD\|341150	cd17261, RMtype1_S_EcoKI-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) TRD2-CR2, Escherichia coli A58 S subunit (S.EcoEI) TRD2-CR2, and Aminomonas paucivorans S subunit (S.Apa12260I) TRD2-CR2. Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) recognizes 5'... AACNNNNNNGTGC ... 3', Escherichia coli A58 S subunit (S.EcoEI) recognizes 5'... GAGNNNNNNNATGC ... 3', and Aminomonas paucivorans S subunit (S.Apa12260I) recognizes 5'... GCCNNNNNCTCC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoKI-TRD1 recognizes AAC/GTT and S.EcoKI-TRD2 recognizes GCAC/GTGC, S.EcoEI TRD1 recognizes GAG/CTC and S.EcoEI TRD2 recognizes GCAT/ATGC, and S.Apa12260I TRD1 recognizes GCC/GGC and S.Apa12260I TRD2 recognizes GGAG/CTCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	5.35967e-53
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.40487e-09
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	4.95649e-101
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.82035e-156
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	5.2807e-44
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	2.69731e-18
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0

>NZ_CP044513.1|WP_000110275.1|3120780_3120984_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP044513.1|WP_000683528.1|3120378_3120660_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP044513.1|WP_002063811.1|3118753_3120379_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP044513.1|WP_080030596.1|3118065_3118275_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVPQDKIQLGIPIIGLLKPHKTLYNRLIGSANI
>NZ_CP044513.1|WP_000578383.1|3116658_3117534_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGKYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEKWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP044513.1|WP_000451409.1|3116184_3116397_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKFWTTALGNINKL
>NZ_CP044513.1|WP_001072141.1|3115614_3116001_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP044513.1|WP_001110344.1|3114720_3115272_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP044513.1|WP_000590871.1|3112366_3113863_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVLEECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP044513.1|WP_001060162.1|3111157_3111994_+|aldo/keto-reductase
MNNKENPLKQMIMLNNGISMPILGLGVWKTKSGKECKEAVLNALEAGYRHIDTARIYDNEVDVGQAIRESRIPRKEIFITTKLWNADQGSDKTRKALENSLDRLGIDFVDLYLIHFPVTSKRMDSWKELEKLYHDKLCKAIGVSNYTIIHLTELLKNSQITPAVNQVEFHPFLNQIHLLEYCKKHKIQLEAYSPLAHGQKIEDPTIAKIAQKYDKTPAQILIRWAIEQKIVVIPKSIKKERIIENSKVFDFAISEEDMKILNSLDEDFRTCWDPSEVV
>NZ_CP044513.1|WP_001216977.1|3123450_3123846_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP044513.1|WP_000026910.1|3124126_3124759_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDPLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP044513.1|WP_000601694.1|3124755_3127008_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWIRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNAKIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSNIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSPNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGTFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEDIAQALIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWN
>NZ_CP044513.1|WP_000098768.1|3127015_3128902_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVKEKEIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEQEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP044513.1|WP_000052101.1|3128966_3129806_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGFDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP044513.1|WP_000371336.1|3129826_3130450_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHREFFSDCEMCFAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPIKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP044513.1|WP_002100227.1|3130610_3130802_+|hypothetical-protein
MVRRSGSSLSMPLGGLDEEKILFWPKLFAKTCKQIKCRNYCFSEKQYFVQINVGTPTLKKEGF
>NZ_CP044513.1|WP_025183357.1|3130959_3131166_+|hypothetical-protein
MPLGDLDEEKICFGPNCFAKVCKRIKCGNYYFSEKRCFVQRNVGTPTLKKRISKFLRLNLQRPDAVRR
>NZ_CP044513.1|WP_000872844.1|3131366_3133268_-|hypothetical-protein
MKYDLLGLYIEEFSIRNKNLENQNVYSVTNSEGFIRSTDFFNKVVFSKDLANYKVVLPNYFAYNPSRLNVGSIDFLSSSDGVIVSPLYVIFKCNDLLFSEYLKRYLKSKTGQMQIKSKTKGAVRDTVSFSSLAEMRIPIPPLADQIHIAHILSQAEALIAQRKESIRLLDELVKSKFLEMFGDPVKNEKGWEVKRLKDVIYGIDSGWSPVCEDYSRSIESEKAILKLGSVTKCKFDPTANKKLPEELEEKKLIEVKDGDVLFTRKNTKELVAAACYVFKTPCNLFLSDLIFRLNYNSDLLNGIYLSNLITEEKYRKQIQSLATGSAGSMPNISKEKLMNFYTLVPPISIQNKFAEFVENIQLQKIQYQRSLIDLETLYSSLSQKAFNGELTANQKSSSTVSAPWLARETSLHVIATDSNKERTTLQKIDKIKAAFSSKKEEQSFLKRKILGSYIINQSLEDSQFGDVKFEKLLHLSEYLILKRNFGQHYVQKVAGPYDNKFTILFFQQIEKDRWFRRIKEGKQFHFQKGEKHESSTKIYNYFSEEELGFVQSLIQLFKKANYEKVEVVSTLYAVWNNRIIKGEPIEDNLLKEDFLNWDSQKTKYKDRLDNAIVWMREKNLVPDGWGPLIEKTK
>NZ_CP044513.1|WP_000429183.1|3133264_3133882_-|Fic-family-protein
MENLERYINDDELSDTDVLIKMAVIHYQFESIHPFYDGNGRTGRILNILYLVLKDLLILLILYLNRYIIQNKTQYYKFLQGVRDKQDWESWILFILIGVEGTFIQTIDMIQSIKQVMMDYKHRVRSSCKFYSQDLINNLFYHSYTKIEFIEKDLGVGRLTAVKYLEELRRLGFLKKQKWGRSNDYINLGLYKILVRREWSRIINI

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Crispr_ID: NZ_CP044513_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_6

3122082-3122264

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder

2 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP044513_6

>merge|NZ_CP044513|6|3122082-3122264|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGTTAGGCGTTGAGCACATACAAAGTTCCGAGTCGAATCGGGATCACTGAATCTGAATATAACTTTGATGTCGTTAGGCGTTGAGCACAGTATGGCTATAGCGGTTTTGGTTTCTTTTTTTATTTTTCTGAATATAACTTTGATGCCGGTAGGCGATTTAGATG

>NZ_CP044513|6|6|3122082-3122264|CRISPRCasFinder
ACTTACAAAAATCGGGTGCCGTTAGGCGTTGAGCAC	ATACAAAGTTCCGAGTCGAATCGGGATCACTGAAT
CTGAATATAACTTTGATGTCGTTAGGCGTTGAGCAC	AGTATGGCTATAGCGGTTTTGGTTTCTTTTTTTATTTTT
CTGAATATAACTTTGATGCCGGTAGGCGATTTAGATG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP044513.1\|WP_025183357.1\|3130959_3131166_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP044513.1\|WP_002100227.1\|3130610_3130802_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP044513.1\|WP_000110275.1\|3120780_3120984_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341150
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP044513.1\|WP_000451409.1\|3116184_3116397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP044513.1\|WP_001072141.1\|3115614_3116001_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001110344.1\|3114720_3115272_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.93224e-135
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.15094e-100
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.00101694
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.5023e-83
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.5418e-164
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.49623e-28
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	gnl\|CDD\|341150	cd17261, RMtype1_S_EcoKI-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) TRD2-CR2, Escherichia coli A58 S subunit (S.EcoEI) TRD2-CR2, and Aminomonas paucivorans S subunit (S.Apa12260I) TRD2-CR2. Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) recognizes 5'... AACNNNNNNGTGC ... 3', Escherichia coli A58 S subunit (S.EcoEI) recognizes 5'... GAGNNNNNNNATGC ... 3', and Aminomonas paucivorans S subunit (S.Apa12260I) recognizes 5'... GCCNNNNNCTCC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoKI-TRD1 recognizes AAC/GTT and S.EcoKI-TRD2 recognizes GCAC/GTGC, S.EcoEI TRD1 recognizes GAG/CTC and S.EcoEI TRD2 recognizes GCAT/ATGC, and S.Apa12260I TRD1 recognizes GCC/GGC and S.Apa12260I TRD2 recognizes GGAG/CTCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	5.35967e-53
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.40487e-09
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	4.95649e-101
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.82035e-156
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	5.2807e-44
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	2.69731e-18
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0

>NZ_CP044513.1|WP_000110275.1|3120780_3120984_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP044513.1|WP_000683528.1|3120378_3120660_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP044513.1|WP_002063811.1|3118753_3120379_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP044513.1|WP_080030596.1|3118065_3118275_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVPQDKIQLGIPIIGLLKPHKTLYNRLIGSANI
>NZ_CP044513.1|WP_000578383.1|3116658_3117534_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGKYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEKWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP044513.1|WP_000451409.1|3116184_3116397_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKFWTTALGNINKL
>NZ_CP044513.1|WP_001072141.1|3115614_3116001_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP044513.1|WP_001110344.1|3114720_3115272_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP044513.1|WP_000590871.1|3112366_3113863_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVLEECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP044513.1|WP_001060162.1|3111157_3111994_+|aldo/keto-reductase
MNNKENPLKQMIMLNNGISMPILGLGVWKTKSGKECKEAVLNALEAGYRHIDTARIYDNEVDVGQAIRESRIPRKEIFITTKLWNADQGSDKTRKALENSLDRLGIDFVDLYLIHFPVTSKRMDSWKELEKLYHDKLCKAIGVSNYTIIHLTELLKNSQITPAVNQVEFHPFLNQIHLLEYCKKHKIQLEAYSPLAHGQKIEDPTIAKIAQKYDKTPAQILIRWAIEQKIVVIPKSIKKERIIENSKVFDFAISEEDMKILNSLDEDFRTCWDPSEVV
>NZ_CP044513.1|WP_001216977.1|3123450_3123846_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP044513.1|WP_000026910.1|3124126_3124759_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDPLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP044513.1|WP_000601694.1|3124755_3127008_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWIRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNAKIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSNIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSPNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGTFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEDIAQALIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWN
>NZ_CP044513.1|WP_000098768.1|3127015_3128902_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVKEKEIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEQEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP044513.1|WP_000052101.1|3128966_3129806_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGFDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP044513.1|WP_000371336.1|3129826_3130450_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHREFFSDCEMCFAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPIKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP044513.1|WP_002100227.1|3130610_3130802_+|hypothetical-protein
MVRRSGSSLSMPLGGLDEEKILFWPKLFAKTCKQIKCRNYCFSEKQYFVQINVGTPTLKKEGF
>NZ_CP044513.1|WP_025183357.1|3130959_3131166_+|hypothetical-protein
MPLGDLDEEKICFGPNCFAKVCKRIKCGNYYFSEKRCFVQRNVGTPTLKKRISKFLRLNLQRPDAVRR
>NZ_CP044513.1|WP_000872844.1|3131366_3133268_-|hypothetical-protein
MKYDLLGLYIEEFSIRNKNLENQNVYSVTNSEGFIRSTDFFNKVVFSKDLANYKVVLPNYFAYNPSRLNVGSIDFLSSSDGVIVSPLYVIFKCNDLLFSEYLKRYLKSKTGQMQIKSKTKGAVRDTVSFSSLAEMRIPIPPLADQIHIAHILSQAEALIAQRKESIRLLDELVKSKFLEMFGDPVKNEKGWEVKRLKDVIYGIDSGWSPVCEDYSRSIESEKAILKLGSVTKCKFDPTANKKLPEELEEKKLIEVKDGDVLFTRKNTKELVAAACYVFKTPCNLFLSDLIFRLNYNSDLLNGIYLSNLITEEKYRKQIQSLATGSAGSMPNISKEKLMNFYTLVPPISIQNKFAEFVENIQLQKIQYQRSLIDLETLYSSLSQKAFNGELTANQKSSSTVSAPWLARETSLHVIATDSNKERTTLQKIDKIKAAFSSKKEEQSFLKRKILGSYIINQSLEDSQFGDVKFEKLLHLSEYLILKRNFGQHYVQKVAGPYDNKFTILFFQQIEKDRWFRRIKEGKQFHFQKGEKHESSTKIYNYFSEEELGFVQSLIQLFKKANYEKVEVVSTLYAVWNNRIIKGEPIEDNLLKEDFLNWDSQKTKYKDRLDNAIVWMREKNLVPDGWGPLIEKTK
>NZ_CP044513.1|WP_000429183.1|3133264_3133882_-|Fic-family-protein
MENLERYINDDELSDTDVLIKMAVIHYQFESIHPFYDGNGRTGRILNILYLVLKDLLILLILYLNRYIIQNKTQYYKFLQGVRDKQDWESWILFILIGVEGTFIQTIDMIQSIKQVMMDYKHRVRSSCKFYSQDLINNLFYHSYTKIEFIEKDLGVGRLTAVKYLEELRRLGFLKKQKWGRSNDYINLGLYKILVRREWSRIINI

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Crispr_ID: NZ_CP044513_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_8

3122684-3123004

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRISPRCasFinder
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	CRT
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	PILER-CR

4 spacers

cas2,cas1,cas6,cas3,cas8b3,cas7,cas5

The CRISPR arrays of NZ_CP044513_8

>merge|NZ_CP044513|8|3122684-3123004|CRISPRCasFinder,CRT,PILER-CR
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCACGAATAACTCGTTCGGAAAGCGTTCTGCGGATCTTCTGAATATAACTTTGATGCCGGTAGGCGTTGAGCACTTGATCGAAAGTCTTCGAATATTAAAATCCGATCCCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACGACAGAATATTAAAAACGAAAGAACAAGAAATCTTGCTGAATATAACTTTGATGCCGTTAGGCGTTGAGCACTTGATCACGACCGGGACTTTGATTGCTGTAGCTATCTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP044513|8|8|3122684-3123004|CRISPRCasFinder
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	GAATAACTCGTTCGGAAAGCGTTCTGCGGATCTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTGATCACGACCGGGACTTTGATTGCTGTAGCTAT
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAAT

>NZ_CP044513|8|2|3122684-3123003|CRT
CTTACAAAAATCGGGATGCCGTTAGGCGTTGAGCAC	GAATAACTCGTTCGGAAAGCGTTCTGCGGATCTT
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	TTGATCACGACCGGGACTTTGATTGCTGTAGCTAT
CTGAATATAACTTTGATGCCGTTAGGCGGTTTAGAA

>NZ_CP044513|8|2|3122754-3122932|PILER-CR
CTGAATATAACTTTGATGCCGGTAGGCGTTGAGCAC	TTGATCGAAAGTCTTCGAATATTAAAATCCGATCC
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC	GACAGAATATTAAAAACGAAAGAACAAGAAATCTTG
CTGAATATAACTTTGATGCCGTTAGGCGTTGAGCAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381297
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379539
NZ_CP044513.1\|WP_025183357.1\|3130959_3131166_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP044513.1\|WP_002100227.1\|3130610_3130802_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|370559
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP044513.1\|WP_000110275.1\|3120780_3120984_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341150
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP044513.1\|WP_000451409.1\|3116184_3116397_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|223562
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP044513.1\|WP_001072141.1\|3115614_3116001_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001110344.1\|3114720_3115272_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_001060162.1\|3111157_3111994_+\|aldo/keto-reductase	gnl\|CDD\|381297	cd19071, AKR_AKR1-5-like, AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.	8.93224e-135
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.15094e-100
NZ_CP044513.1\|WP_000578383.1\|3116658_3117534_+\|hypothetical-protein	gnl\|CDD\|379539	pfam14284, PcfJ, PcfJ-like protein. The PcfJ-like protein family includes the E. faecalis PcfJ protein, which is functionally uncharacterized. It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	0.00101694
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.5023e-83
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.5418e-164
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.49623e-28
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	gnl\|CDD\|341150	cd17261, RMtype1_S_EcoKI-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) TRD2-CR2, Escherichia coli A58 S subunit (S.EcoEI) TRD2-CR2, and Aminomonas paucivorans S subunit (S.Apa12260I) TRD2-CR2. Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) recognizes 5'... AACNNNNNNGTGC ... 3', Escherichia coli A58 S subunit (S.EcoEI) recognizes 5'... GAGNNNNNNNATGC ... 3', and Aminomonas paucivorans S subunit (S.Apa12260I) recognizes 5'... GCCNNNNNCTCC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoKI-TRD1 recognizes AAC/GTT and S.EcoKI-TRD2 recognizes GCAC/GTGC, S.EcoEI TRD1 recognizes GAG/CTC and S.EcoEI TRD2 recognizes GCAT/ATGC, and S.Apa12260I TRD1 recognizes GCC/GGC and S.Apa12260I TRD2 recognizes GGAG/CTCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	5.35967e-53
NZ_CP044513.1\|WP_080030596.1\|3118065_3118275_+\|hypothetical-protein	gnl\|CDD\|370559	pfam09559, Cas6, Cas6 Crispr. The Cas6 Crispr family of proteins averaging 140 residues are characterized by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus. The CRISPR-Cas system is possibly a mechanism of defense against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes.	1.40487e-09
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	4.95649e-101
NZ_CP044513.1\|WP_000590871.1\|3112366_3113863_+\|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.82035e-156
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	5.2807e-44
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	2.69731e-18
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0

>NZ_CP044513.1|WP_000110275.1|3120780_3120984_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP044513.1|WP_000683528.1|3120378_3120660_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP044513.1|WP_002063811.1|3118753_3120379_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP044513.1|WP_080030596.1|3118065_3118275_+|hypothetical-protein
MGPLQSNLHLNTTSKLRIRAEQPLLSHLLKLAGKNLEVPQDKIQLGIPIIGLLKPHKTLYNRLIGSANI
>NZ_CP044513.1|WP_000578383.1|3116658_3117534_+|hypothetical-protein
MIFVLEYCLENPKSIFLVIPKDFETVREKFPFLKRKVIATYFGFHPSSLNVLEKITDSAVQNGYLKTFQNLYSIPVFQKAFHHLPIINEFIIQFFNYSRAKNWNEKWDILFLKDLLFRFPNPNFEEEDFERTFQLYEEVKRFSPSWKIRSLEHLKDLEQKMIQKIQKNEFIGPDQPYPTPPMEKEDWLEPINSRKELFLESRIQHNCIFSYDTRILEGKYYIYRIFFPERCTLSLFYINGDWYLDQIAAAFNKEAKAETLRKVEKWRMQNGIFVLGDAFRLGIPPDWIFAR
>NZ_CP044513.1|WP_000451409.1|3116184_3116397_-|hypothetical-protein
MEVAFSKAGQPVRFRMLKYSLMFSLLYLLRDSEYLWSVLISAFFISLTVHLWFGYKTKFWTTALGNINKL
>NZ_CP044513.1|WP_001072141.1|3115614_3116001_+|hypothetical-protein
MNQKIFKSIWAIIAGFLTIFILSTAVDLILHQTGIYPPMGVIMSDELFALATAYRVLFGILSGYVTAKIAPDQPVKHSLALGVLGLIVSITGAIVMWDAGPAWYSLAIIAIALPCSWAGGILYERSQT
>NZ_CP044513.1|WP_001110344.1|3114720_3115272_+|hypothetical-protein
MNYYILEEVNYHLNIPYIGDLPEELDTIDVMTGRKIEISNLPIRVPIKIDYESEIVYPDIMTADLPLFSEKIRNSLDQIEIKNIQYYPVELFEDQTGQTKANYYMSILPVSVECLKSGINRSPAGRLILKNPIIDPTKILGLKLFRLGEEPSLIIIDSMVKDTLTNAHLNGVSFIPLEEYTSS
>NZ_CP044513.1|WP_000590871.1|3112366_3113863_+|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MIKISGLNKAFTTKVLFDDLNLSINRGEKVGLVGRNGHGKSTLFQVILGNVEADSGTISIPKGYKIGHLQQHLHFTKPTVLEECSLGLPEGEEYETWKVEKILSGLGFSEQDMEKNPNEFSGGYQIRMNLAKLLVSSPDMLMLDEPNNYLDIVTIRWLEEFLREWEGEIILVTHDRGFMDAVVTHTIAIHRTKAIKVQGDTDKLYNQINQSEEIYEKTRLNEAKKRKQEEIFIAKFKAKASFASRAQSRVKKLEKQGEMKELEKIQDLELYFNSAPFNANQMLSAENLSFSYDGKEPFLIENFSISVGSRERICIIGKNGKGKSTLLKILAGELETSQGTIKKHPVLKEGYFGQTNKLNLNENSTVVEEIMISDPSCNEWKARTIAGGLMFSEDQALKKIKVLSGGEKSRVLLGKILVTPCHLLYLDEPTNHLDMQSCDSLIEAIDEFDGSVIMVTHDELHLRAVATKLIVFDNDSIQIFNGSYDDFLNDVGWSNEHY
>NZ_CP044513.1|WP_001060162.1|3111157_3111994_+|aldo/keto-reductase
MNNKENPLKQMIMLNNGISMPILGLGVWKTKSGKECKEAVLNALEAGYRHIDTARIYDNEVDVGQAIRESRIPRKEIFITTKLWNADQGSDKTRKALENSLDRLGIDFVDLYLIHFPVTSKRMDSWKELEKLYHDKLCKAIGVSNYTIIHLTELLKNSQITPAVNQVEFHPFLNQIHLLEYCKKHKIQLEAYSPLAHGQKIEDPTIAKIAQKYDKTPAQILIRWAIEQKIVVIPKSIKKERIIENSKVFDFAISEEDMKILNSLDEDFRTCWDPSEVV
>NZ_CP044513.1|WP_001216977.1|3123450_3123846_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP044513.1|WP_000026910.1|3124126_3124759_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDPLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP044513.1|WP_000601694.1|3124755_3127008_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWIRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNAKIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSNIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSPNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGTFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEDIAQALIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWN
>NZ_CP044513.1|WP_000098768.1|3127015_3128902_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVKEKEIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEQEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP044513.1|WP_000052101.1|3128966_3129806_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGFDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP044513.1|WP_000371336.1|3129826_3130450_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHREFFSDCEMCFAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPIKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP044513.1|WP_002100227.1|3130610_3130802_+|hypothetical-protein
MVRRSGSSLSMPLGGLDEEKILFWPKLFAKTCKQIKCRNYCFSEKQYFVQINVGTPTLKKEGF
>NZ_CP044513.1|WP_025183357.1|3130959_3131166_+|hypothetical-protein
MPLGDLDEEKICFGPNCFAKVCKRIKCGNYYFSEKRCFVQRNVGTPTLKKRISKFLRLNLQRPDAVRR
>NZ_CP044513.1|WP_000872844.1|3131366_3133268_-|hypothetical-protein
MKYDLLGLYIEEFSIRNKNLENQNVYSVTNSEGFIRSTDFFNKVVFSKDLANYKVVLPNYFAYNPSRLNVGSIDFLSSSDGVIVSPLYVIFKCNDLLFSEYLKRYLKSKTGQMQIKSKTKGAVRDTVSFSSLAEMRIPIPPLADQIHIAHILSQAEALIAQRKESIRLLDELVKSKFLEMFGDPVKNEKGWEVKRLKDVIYGIDSGWSPVCEDYSRSIESEKAILKLGSVTKCKFDPTANKKLPEELEEKKLIEVKDGDVLFTRKNTKELVAAACYVFKTPCNLFLSDLIFRLNYNSDLLNGIYLSNLITEEKYRKQIQSLATGSAGSMPNISKEKLMNFYTLVPPISIQNKFAEFVENIQLQKIQYQRSLIDLETLYSSLSQKAFNGELTANQKSSSTVSAPWLARETSLHVIATDSNKERTTLQKIDKIKAAFSSKKEEQSFLKRKILGSYIINQSLEDSQFGDVKFEKLLHLSEYLILKRNFGQHYVQKVAGPYDNKFTILFFQQIEKDRWFRRIKEGKQFHFQKGEKHESSTKIYNYFSEEELGFVQSLIQLFKKANYEKVEVVSTLYAVWNNRIIKGEPIEDNLLKEDFLNWDSQKTKYKDRLDNAIVWMREKNLVPDGWGPLIEKTK
>NZ_CP044513.1|WP_000429183.1|3133264_3133882_-|Fic-family-protein
MENLERYINDDELSDTDVLIKMAVIHYQFESIHPFYDGNGRTGRILNILYLVLKDLLILLILYLNRYIIQNKTQYYKFLQGVRDKQDWESWILFILIGVEGTFIQTIDMIQSIKQVMMDYKHRVRSSCKFYSQDLINNLFYHSYTKIEFIEKDLGVGRLTAVKYLEELRRLGFLKKQKWGRSNDYINLGLYKILVRREWSRIINI

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Crispr_ID: NZ_CP044513_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_10

3130872-3130969

Unclear

I-A,I-B,II-B

Consensus_repeat	Method
TCTGAATATAACTTTGATGCCGTTAG	CRISPRCasFinder

1 spacers

cas5,cas7,cas8b3,cas3,cas6,cas2,cas1

The CRISPR arrays of NZ_CP044513_10

>merge|NZ_CP044513|10|3130872-3130969|CRISPRCasFinder
TCTGAATATAACTTTGATGCCGTTAGACGTTGAGCGCAGGGATTAAAAACGGACACTGGTGTCCGTTTTGGTTCTGAATATAACTTTGATGCCGTTAG

>NZ_CP044513|10|10|3130872-3130969|CRISPRCasFinder
TCTGAATATAACTTTGATGCCGTTAG	ACGTTGAGCGCAGGGATTAAAAACGGACACTGGTGTCCGTTTTGGT
TCTGAATATAACTTTGATGCCGTTAG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_000917044.1\|3139030_3139246_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000834271.1\|3135964_3138766_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|226581
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	cas5	cd09688_cas5_CAS-I-B	gnl\|CDD\|131635
NZ_CP044513.1\|WP_000903065.1\|3134384_3135965_-\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|280533
NZ_CP044513.1\|WP_002064447.1\|3133894_3134113_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001140542.1\|3139761_3140190_+\|RNA-binding-protein	unknown	unknown	gnl\|CDD\|227269
NZ_CP044513.1\|WP_000199614.1\|3140539_3142081_+\|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl\|CDD\|211578
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	cas8b3	cd09713_cas8b3_CAS-I-B	gnl\|CDD\|132524
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350320
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	cas7	cd09687_cas7_CAS-I-B	gnl\|CDD\|187818
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
NZ_CP044513.1\|WP_000110275.1\|3120780_3120984_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341150
NZ_CP044513.1\|WP_082269455.1\|3134036_3134297_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379367
NZ_CP044513.1\|WP_002100227.1\|3130610_3130802_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	cas6	cd09703_cas6_CAS-I:CAS-III	gnl\|CDD\|274308
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|187770
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	cas2	pfam09827_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|378256
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|274899
NZ_CP044513.1\|WP_000533551.1\|3140182_3140365_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_000834271.1\|3135964_3138766_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|226581	COG4096, HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	0
NZ_CP044513.1\|WP_000371336.1\|3129826_3130450_+\|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS	gnl\|CDD\|131635	TIGR02586, CRISPR-associated_protein_Cas5, CRISPR-associated protein Cas5/DevS, subtype MYXAN. This model represents DevS of Myxococcus xanthus and related proteins of Leptospira interrogans and Gemmata obscuriglobus. This protein is encoded in a cluster of CRISPR-associated (cas) genes, and in the special case of Myxococcus xanthus has taken on a role in the control of fruiting body development. CRISPRs are clustered, regularly interspaced short palidromic repeats. This protein family is related to models TIGR01868, TIGR01895, and TIGR01876.	1.15094e-100
NZ_CP044513.1\|WP_000903065.1\|3134384_3135965_-\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	3.39877e-54
NZ_CP044513.1\|WP_000199614.1\|3140539_3142081_+\|type-I-restriction-modification-system-subunit-M	gnl\|CDD\|211578	TIGR00497, hsdM, type I restriction system adenine methylase (hsdM). Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification].	0
NZ_CP044513.1\|WP_001140542.1\|3139761_3140190_+\|RNA-binding-protein	gnl\|CDD\|227269	COG4933, COG4933, Uncharacterized conserved protein [Function unknown].	8.13427e-15
NZ_CP044513.1\|WP_000052101.1\|3128966_3129806_+\|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR	gnl\|CDD\|187818	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Cst2/DevR family.	5.5023e-83
NZ_CP044513.1\|WP_001216977.1\|3123450_3123846_+\|PIN-domain-containing-protein	gnl\|CDD\|350320	cd18753, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	5.45057e-41
NZ_CP044513.1\|WP_000098768.1\|3127015_3128902_+\|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1	gnl\|CDD\|132524	TIGR03485, hypothetical_protein_L8106_30105, CRISPR-associated protein Cas8a1/Csx13, MYXAN subtype. Members of this family are found among cas (CRISPR-Associated) genes close to CRISPR repeats in Leptospira interrogans (a spirochete), Myxococcus xanthus (a delta-proteobacterium), and Lyngbya sp. PCC 8106 (a cyanobacterium). It is found with other cas genes in Anabaena variabilis ATCC 29413. In Lyngbya sp., the protein is split into two tandem genes. This model corresponds to the N-terminal region or upstream gene; the C-terminal region is described by TIGR03486. CRISPR/cas systems are associated with prokaryotic acquired resistance to phage and other exogenous DNA.	3.5418e-164
NZ_CP044513.1\|WP_000429183.1\|3133264_3133882_-\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	3.49623e-28
NZ_CP044513.1\|WP_000872844.1\|3131366_3133268_-\|hypothetical-protein	gnl\|CDD\|341150	cd17261, RMtype1_S_EcoKI-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) TRD2-CR2, Escherichia coli A58 S subunit (S.EcoEI) TRD2-CR2, and Aminomonas paucivorans S subunit (S.Apa12260I) TRD2-CR2. Escherichia coli str. K-12 substr. MG1655 S subunit (S.EcoKI) recognizes 5'... AACNNNNNNGTGC ... 3', Escherichia coli A58 S subunit (S.EcoEI) recognizes 5'... GAGNNNNNNNATGC ... 3', and Aminomonas paucivorans S subunit (S.Apa12260I) recognizes 5'... GCCNNNNNCTCC ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, S.EcoKI-TRD1 recognizes AAC/GTT and S.EcoKI-TRD2 recognizes GCAC/GTGC, S.EcoEI TRD1 recognizes GAG/CTC and S.EcoEI TRD2 recognizes GCAT/ATGC, and S.Apa12260I TRD1 recognizes GCC/GGC and S.Apa12260I TRD2 recognizes GGAG/CTCC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	5.35967e-53
NZ_CP044513.1\|WP_082269455.1\|3134036_3134297_-\|hypothetical-protein	gnl\|CDD\|379367	pfam13784, Fic_N, Fic/DOC family N-terminal. This domain is found at the N-terminus of the Fic/DOC family, pfam02661.	1.52652e-14
NZ_CP044513.1\|WP_000026910.1\|3124126_3124759_+\|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6	gnl\|CDD\|274308	TIGR02807, hypothetical_protein_LA_3189, CRISPR-associated protein Cas6, subtype MYXAN. Members of this protein family resemble the Cas6 proteins described by TIGR01877 in having a C-terminal motif GXGXXXXXGXG, where the single X of each GXG is hydrophobic and the spacer XXXXX has at least one Lys or Arg. Examples are found in cas gene operons of CRISPR regions in Anabaena variabilis ATCC 29413, Leptospira interrogans, Gemmata obscuriglobus UQM 2246, and twice in Myxococcus xanthus DK 1622. Oddly, an orphan member is found in Thiobacillus denitrificans ATCC 25259, whose genome does not seem to contain other evidence of CRISPR repeats or cas genes.	4.95649e-101
NZ_CP044513.1\|WP_000601694.1\|3124755_3127008_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|187770	cd09639, Cas3_I, CRISPR/Cas system-associated protein Cas3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I.	5.2807e-44
NZ_CP044513.1\|WP_000683528.1\|3120378_3120660_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|378256	pfam09827, CRISPR_Cas2, CRISPR associated protein Cas2. Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	2.69731e-18
NZ_CP044513.1\|WP_002063811.1\|3118753_3120379_+\|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1	gnl\|CDD\|274899	TIGR03983, hypothetical_protein_LA3181, CRISPR-associated endonuclease Cas1, subtype MYXAN. Members of this protein are the Cas1 endonuclease, or Cas1 domain in Cas4/Cas1 fusion proteins, of the MYXAN subtype of CRISPR/Cas systems. These systems typically feature repeats and spacers each about 36 base pairs in length. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, Anabaena variabilis ATCC 29413, etc.	0

>NZ_CP044513.1|WP_002100227.1|3130610_3130802_+|hypothetical-protein
MVRRSGSSLSMPLGGLDEEKILFWPKLFAKTCKQIKCRNYCFSEKQYFVQINVGTPTLKKEGF
>NZ_CP044513.1|WP_000371336.1|3129826_3130450_+|type-I-MYXAN-CRISPR-associated-protein-Cas5/Cmx5/DevS
MDPLILYYEIPIASFRPYQSREYQDSYPVPPPSTLIGMSLSLCGLSMDHREFFSDCEMCFAVADSNPARSTVLRRMRRLGDSGRDPKQRRPEYQELVTGIRGIVAYRGLPAELAKPIKTVLTTPEKIIRYGGLSLGESSFLVDVIRLFGLPDTTQSNWSWLIPDMKGSLDLPVWIDTISPSLTTKFRFSFQSAEGIPENAWFKLRPS
>NZ_CP044513.1|WP_000052101.1|3128966_3129806_+|type-I-B-CRISPR-associated-protein-Cas7/Cst2/DevR
MSLHIFGTILTPHGVAANNRGENEGNLSTLQKLLWNGEVHSTVSGEAIRYALRETWMEDHENLLNRKIKSEGFDWQDETFKKPDRYLDDTILGFMDPKKETNKRRASLEITRAVSTRPWIGDVSFNVASVGAQRTNKNPIPYATEIHATRYQYSFALSGDDVKSEWKGLALDGLASLRRVAGNHSRFLYDFSPESIVLRVTHDPAPRILYCFREEGDTIDLKNLAKRVASGDVKAEELILGGEIASEQDAIELKTKGATVFPGIKAAVEDAKKRIGKSA
>NZ_CP044513.1|WP_000098768.1|3127015_3128902_+|type-I-MYXAN-CRISPR-associated-Cas8a1/Cmx1
MSSRPSASIETTPNTPVVFQRGLSECTSPLLRAGLAGLYSTLYSLENEKKPKTLSWELTQDSIQITSKGEFSKDFQWIINHGYQTKEGIFYCPGIHRTKTIHKDRMHFHNAMMGTFLQHGRIQVRTKGGGTAVSIEDECKLLYFPLLVKEKEIKYRKDAESILFAEKRGSTWSFENLVELSGYVMPGAPPRFTHETSWIGTIADAFLLFFAPLSCSFAEIEPSRGTWCILIPELEDLETFERFRRDYEVNTINMFAGGPGDAALRYLTEMDLTGNKKDFSPNGCEVYVIGKVAWNKKQQVRRLMMRIHPTEKNFRIYKKMRGIFQNKIHLKKTDASSKSKKSRTRSTDKNKTQKKKDENYHWVSSPYAAARIAENLVQGKRWYYQFAKPLSWYIDTLERKRKSSPGSSHEKIWFESIRRFERAELIKFMENNEIWNSEEEQWFVKSFHETLSRLYAKEASHLNRRGGSRTLGDRWKHMNEKIYRDLAQAKTSPQIRTVISDLWAKSGRPPSLQEHTGALWKFISKDSEYARDLSLVALASYQGSSSLFRETVKDAVQKDEGRQLSLNLEKATTQEQVLKAYQTLWDFVETNDEQEKNDLEVFVTKNWKRALEIGQEEIQKAKKKSNDA
>NZ_CP044513.1|WP_000601694.1|3124755_3127008_+|CRISPR-associated-helicase/endonuclease-Cas3
MILLAKSYPGIEKQLKSGDPESWALLEHHSSATYQVAEVLLKILEPILRKWIRLSESEYNKFVLVVCLSAGLHDLGKANEDFQKMLQRRKYLQRFRHEIWSVLALTGSGPFSDWFRKTIGDETWVRIGQMGILSHHLKATRETLYADHETAEIKVFWKDQGVIKMFQSICRLAGISSPDFSSPSISSYTCLGEDADKSIRIWTREILNAKIDPRYQHSIGAVRAMIIAADRLASAYKGADALKLWAEEALNRVLSEQECSNIVKQGLGEKNLRPFQKQVGDSTSRVTLVRAGCGNGKTIAAFQWAKTHSAGRKLFFCYPTMGTATEGFRDYVSDIPGLDALLSHSRASLDLGELASTGEEDEGDSPNMHSRMLQEWTAQVTFCTVDQILGLLQNYRSSLTLSPAIFLGTFVFDEIHMYDSILFGNLLTFLKEFSHTSILLMTASLPETMLSAIQETVGADLGPVISGEAQIEERLRYRILHSSREDALQKAIQEFKNGGRVLWVCNKVEHCLKLYDELSEKYDIEALVYHSRFKYEDRKERHRAVIDSFQEGYKKSLPVFAITTQVCEVSLDISATLLISELCPFAALIQRLGRVNRPGQEMEDIAQALIIPFQGKPYEKENEDDGESELERCKEILKPLLDRELSQKDLALALENAKGTEHQKIPSQWLSLGWEAKPDSIRESGYTLDVILESDAYKVLKNERPWEKSKLYTIPMPIQKQFSYGEPPLRIPVVPDSQIQYSSVRGGEWN
>NZ_CP044513.1|WP_000026910.1|3124126_3124759_+|type-I-MYXAN-CRISPR-associated-protein-Cas6/Cmx6
MSIPNVIELNFPVLGSLLPADHGYGLYSAICHLCPTLHEHDPLSIQTISGLPDRPGILRLTANSQLRIRIPVEQIPLVYPLAGKSLTIGIHKIQLSIPAIRILQPYSVLKSRITVIKGFSEPETFLEAAQKQLNAREISGRVILLQDPKGNPKRNTIKIKRFTIVGFGLKVEGLNEKDSLELQVTGLGGKRRMGCGVFYGDSNKVESKAS
>NZ_CP044513.1|WP_001216977.1|3123450_3123846_+|PIN-domain-containing-protein
MRIALDAYAYIAFTKGNPRMTKWIQEAEHIYIPFVVLGELRAGFLSGNRTNKKERSLKKFLNDPRVIILYPDKQTIHYYSQIRKDLKKHGTLISENDEWIAASAISRKIPLCTMNKDFENVGSLNIKKIDV
>NZ_CP044513.1|WP_000110275.1|3120780_3120984_-|hypothetical-protein
MSVFKGGEQVYRFLSLFFMFGFFRSAYFVSKDHFVSNIKIQVCLSSSPIINLAGIFTRKKNERWAIN
>NZ_CP044513.1|WP_000683528.1|3120378_3120660_+|CRISPR-associated-endonuclease-Cas2
MKHWRLVSYDIREPKRLRRVAKIMEGFGERIQYSVFRIYSTDKELEKLRWKLAKVTEEDNIFYLTLCTKCASGAHTQEKKSAWPEAPKTLKIL
>NZ_CP044513.1|WP_002063811.1|3118753_3120379_+|type-I-MYXAN-CRISPR-associated-endonuclease-Cas4/Cas1
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKELSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>NZ_CP044513.1|WP_000872844.1|3131366_3133268_-|hypothetical-protein
MKYDLLGLYIEEFSIRNKNLENQNVYSVTNSEGFIRSTDFFNKVVFSKDLANYKVVLPNYFAYNPSRLNVGSIDFLSSSDGVIVSPLYVIFKCNDLLFSEYLKRYLKSKTGQMQIKSKTKGAVRDTVSFSSLAEMRIPIPPLADQIHIAHILSQAEALIAQRKESIRLLDELVKSKFLEMFGDPVKNEKGWEVKRLKDVIYGIDSGWSPVCEDYSRSIESEKAILKLGSVTKCKFDPTANKKLPEELEEKKLIEVKDGDVLFTRKNTKELVAAACYVFKTPCNLFLSDLIFRLNYNSDLLNGIYLSNLITEEKYRKQIQSLATGSAGSMPNISKEKLMNFYTLVPPISIQNKFAEFVENIQLQKIQYQRSLIDLETLYSSLSQKAFNGELTANQKSSSTVSAPWLARETSLHVIATDSNKERTTLQKIDKIKAAFSSKKEEQSFLKRKILGSYIINQSLEDSQFGDVKFEKLLHLSEYLILKRNFGQHYVQKVAGPYDNKFTILFFQQIEKDRWFRRIKEGKQFHFQKGEKHESSTKIYNYFSEEELGFVQSLIQLFKKANYEKVEVVSTLYAVWNNRIIKGEPIEDNLLKEDFLNWDSQKTKYKDRLDNAIVWMREKNLVPDGWGPLIEKTK
>NZ_CP044513.1|WP_000429183.1|3133264_3133882_-|Fic-family-protein
MENLERYINDDELSDTDVLIKMAVIHYQFESIHPFYDGNGRTGRILNILYLVLKDLLILLILYLNRYIIQNKTQYYKFLQGVRDKQDWESWILFILIGVEGTFIQTIDMIQSIKQVMMDYKHRVRSSCKFYSQDLINNLFYHSYTKIEFIEKDLGVGRLTAVKYLEELRRLGFLKKQKWGRSNDYINLGLYKILVRREWSRIINI
>NZ_CP044513.1|WP_002064447.1|3133894_3134113_-|hypothetical-protein
MKPAAKEVGNYASALRKGFQLVKDSKLLTGKHILAVQEELEKNKAGYRRLSGTDLKNQQTGEVIYTPPQSLK
>NZ_CP044513.1|WP_082269455.1|3134036_3134297_-|hypothetical-protein
MNPAFVLKKVSSAHRHLKGISSNILNQNISIHTLSLQEAKDSSAVENIATHDELFKEKIFPNETRSQRSRKLCIRFTKRISIGKRF
>NZ_CP044513.1|WP_000903065.1|3134384_3135965_-|type-I-restriction-modification-system-subunit-M
MLHNNPQLKSLIDKLWNNFWSGGISNPLTAIEQITYLIFMKRLDDLEAKRERDAEFIGEKYKSRFSGRYKVPGSNELIDKKKLRWSEFKHFTADEMLLHIQTKVFPFLKELTGDASPFTHHMQNAVFIIPKASLLSEAIQIIESIFSEIERDTNEGRQAFQDIQGDVYEMLLGEIASAGKNGQFRTPRHIIKLIAELVAPRLGQRVADPACGTGGFLLGAYQFMLTDYIRKKDSKQIVPDEDGFERGFLSSVIDKKVKTILDDSFYGYDIDTTMVRLGLMNLMMHGIDEPHINYKDSLSKKFNEDGRYDIVLANPPFTGNIDEGDIHESLALPTTKSELLFVERIFNMLRMGGTAGVIVPQGVLFGSGKAFVTLRKKLLEEAELKAVITLPSGVFKPYAGVSTAILIFTKGGETKHTWFYELLADGYTLDDKRTKIHQSDLKDIVSRFHSRNPKEETKRTERGFFVPKNEIVGDKPEESKYDLSLSKYKEEVYEEIQYESPKVILSRLQDLEKQIQKGLSELQKQI
>NZ_CP044513.1|WP_000834271.1|3135964_3138766_-|DEAD/DEAH-box-helicase
MKSEKETRKDIIDQRLQKAGWNLQDRTQVIEEFDIEVKNFNGLLKARSSTAQHQFSDYVLIGKNGKPIAVVEAKKTSKDSAIGREQAKQYCHSIQEKHGGSLPFCFYTNGHDIYFWDLGNYPPKKVYGFPTRHDLERYSYLRETRKPLVSESIDTKIAGRTYQIASIRAVMEAIEKKRKKFLLVMATGTGKTRTCVALVDALMRSGWVNRTLFLVDRIALRRQTLDAFKEYLPDEPIWPKEGELEISRERRIYVSTYPTMLNIIRDEIQPLSPHFFDLVVVDESHRSIYNTYQEILDYFNTITLGLTATPTDIIDHNTFRLFECEDGVPTFVYSYEEAVNHVPPYLCNFQIMKIKSKFQAEGINERTISLADQKKLILEGREIEEINFEGTELEKTVINRGTNSLIVREFMEECIKDPDGVLPGKTIFFCMTKAHARRMEEIFDSLYPEYKGEIAKVIVSEDPRVHGTGGLLDQFIKNDMPRIAISVDMLDTGIDVREIVNLVFAKPVYSYTKFWQMIGRGTRLLEEDKIKHWCPEKNSFLIIDCWDNFEYFKLNPKGKPTSPQIPLPVRLFGLRLDKVAKAIELKEDTIFQKEILNLQRQISALPKMSVVVLEARNELQRLEEENFWKYLSPEKLEFLYSSIKPLFRIASAIDFKAMRFEKDIVEISLAHLFGEKERFETLKESIVEKIENLPLEIHIVAQEKELIQTSQTNSFWATINEHKFDTLIEKLSPLMKYSLSFGPLDGPARFDLEDFVSEKEYIEFGPSHEALSVAKYRELVEQKINELVSESPILKKIKEGKDISKIESELLAEELYNQHPHITIDLLRRVYQNRKAELVQFIKHILGIEILESFSETVSKTFENFIRNHSYLTSRQLQFMDVLKNYILEKGELQKRNLIESPFTLLHPEGIRGVFSPKEIEEILDLAKKVVAA
>NZ_CP044513.1|WP_000917044.1|3139030_3139246_-|hypothetical-protein
MLKNTIKSGETGTKRKVKSLASWPFLFQERSFKTFDQQTTVLRSVKEKPDKYVWLFAFLARVITERHQSYI
>NZ_CP044513.1|WP_001140542.1|3139761_3140190_+|RNA-binding-protein
MAKTKNRRVVFLPIKPEFAHKIINGEKNIEFRKKFSSQEVETIVIYSSSPEKRVIGYATVDSIVIDTPDSLWKRFYKKGGIDKDRFSFYFNGKETGVGIRIKNVSRLKEAVTPTQLGIQGAIPQNFKFLEKGIITILERNLI
>NZ_CP044513.1|WP_000533551.1|3140182_3140365_-|hypothetical-protein
MGRRGKIATEHNPSEILRDLSLPNFTFSAMILKKALKFLLSFVSRSLVSKANSNLVFFLK
>NZ_CP044513.1|WP_000199614.1|3140539_3142081_+|type-I-restriction-modification-system-subunit-M
MTSAQQRAALQRQIWQIANDVRGAVDGWDFKQYVLGTLFYRFISENFTNYMEGGDSSIQYSKLNDKKITKEIKDDAIKTRGYFIYPSQLFTNIVTKADDNESLNTDLAGIFKDIESSANGFPSEHDIKGLFADFDTTSNRLGNTVKDKNSRLAAVLKRVAELDFGDFDSSHIDLFGDAYEFLISNYAANAGKSGGEFFTPQHVSKLIARLAIHKQTRINKIYDPACGSGSLLLQAKKQFDDHIIEEGFFGQEINHTTYNLARMNMFLHNINYDKFDIELGNTLIDPQHNHEKPFDAIVSNPPYSINWKGSDDPTLINDERFAPAGVLAPKSKADFAFVLHALSYLSSKGRAAIVCFPGIFYRSGAEQKIRQYLVGNNFVETVISLAPNLFFGTTIAVNILVLSKHKTDTNTQFIDASGLFKKETNNNILTEDHIERIMQTFDSKVDTEHFAKSVSVETIANNDYNLSVSSYVEAKDNREVIDIQKLNAELKITVAKIDQLRADIDAIVAEIEG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP044513_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_11

3365637-3365731

Orphan

Consensus_repeat	Method
ATTTGTAATAGTTCCCACATTTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044513_11

>merge|NZ_CP044513|11|3365637-3365731|CRISPRCasFinder
ATTTGTAATAGTTCCCACATTTTTCAAATTTGGCTGTAGTTACGACCCAAGATTCAAAGATAAAATCTAGTGATTTGTAATAGTTCCTACATTTT

>NZ_CP044513|11|11|3365637-3365731|CRISPRCasFinder
ATTTGTAATAGTTCCCACATTTT	TCAAATTTGGCTGTAGTTACGACCCAAGATTCAAAGATAAAATCTAGTG
ATTTGTAATAGTTCCTACATTTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_000671562.1\|3364148_3365540_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	unknown	unknown	gnl\|CDD\|223842
NZ_CP044513.1\|WP_000884017.1\|3363733_3364066_-\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|132914
NZ_CP044513.1\|WP_000885366.1\|3375911_3376112_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000092395.1\|3367795_3369691_+\|DUF1561-domain-containing-protein	unknown	unknown	gnl\|CDD\|284921
NZ_CP044513.1\|WP_082268216.1\|3377071_3377380_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000778965.1\|3373629_3374955_-\|thiolase-family-protein	unknown	unknown	gnl\|CDD\|238383
NZ_CP044513.1\|WP_000622612.1\|3360408_3361458_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|172940
NZ_CP044513.1\|WP_001068430.1\|3360093_3360378_-\|Cys-rich-protein	unknown	unknown	gnl\|CDD\|275246
NZ_CP044513.1\|WP_000099245.1\|3362968_3363727_-\|indole-3-glycerol-phosphate-synthase	unknown	unknown	gnl\|CDD\|140013
NZ_CP044513.1\|WP_001181792.1\|3371095_3371854_-\|biotin--[acetyl-CoA-carboxylase]-ligase	unknown	unknown	gnl\|CDD\|223417
NZ_CP044513.1\|WP_100221011.1\|3356024_3356369_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000559675.1\|3374991_3375852_-\|acyl-[acyl-carrier-protein]-thioesterase	unknown	unknown	gnl\|CDD\|238329
NZ_CP044513.1\|WP_002064352.1\|3361387_3361702_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_001021444.1\|3367183_3367429_+\|DUF1563-domain-containing-protein	unknown	unknown	gnl\|CDD\|203693
NZ_CP044513.1\|WP_000856977.1\|3376092_3376707_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP044513.1\|WP_001007304.1\|3357150_3357987_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372640
NZ_CP044513.1\|WP_001024698.1\|3356927_3357140_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000928025.1\|3370320_3371094_-\|type-III-pantothenate-kinase	unknown	unknown	gnl\|CDD\|237347
NZ_CP044513.1\|WP_001187394.1\|3373178_3373370_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_002117956.1\|3358342_3360079_-\|glycosyltransferase-family-39-protein	unknown	unknown	gnl\|CDD\|224720

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_000671562.1\|3364148_3365540_+\|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase	gnl\|CDD\|223842	COG0771, MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane].	2.86555e-116
NZ_CP044513.1\|WP_000884017.1\|3363733_3364066_-\|STAS-domain-containing-protein	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.75168e-26
NZ_CP044513.1\|WP_000856977.1\|3376092_3376707_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.66078e-12
NZ_CP044513.1\|WP_000092395.1\|3367795_3369691_+\|DUF1561-domain-containing-protein	gnl\|CDD\|284921	pfam07598, DUF1561, Protein of unknown function (DUF1561). A family of paralogous proteins in Leptospira interrogans.	0
NZ_CP044513.1\|WP_000778965.1\|3373629_3374955_-\|thiolase-family-protein	gnl\|CDD\|238383	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and eukaryotes (cytosol, microbodies and mitochondria). There are 2 functional different classes: thiolase-I (3-ketoacyl-CoA thiolase) and thiolase-II (acetoacetyl-CoA thiolase). Thiolase-I can cleave longer fatty acid molecules and plays an important role in the beta-oxidative degradation of fatty acids. Thiolase-II has a high substrate specificity. Although it can cleave acetoacyl-CoA, its main function is the synthesis of acetoacyl-CoA from two molecules of acetyl-CoA, which gives it importance in several biosynthetic pathways.	2.29061e-112
NZ_CP044513.1\|WP_000622612.1\|3360408_3361458_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|172940	PRK14465, PRK14465, 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN.	0
NZ_CP044513.1\|WP_001068430.1\|3360093_3360378_-\|Cys-rich-protein	gnl\|CDD\|275246	TIGR04453, Lepto_8Cys, Cys-rich protein, LA_1312 family. Members of this protein family occur, so far, exclusively in the genus Leptospira. Members, although small (about 90 amino acids), have a predicted signal peptide followed by a region with eight invariant Cys residues. Some members have an additional Cys in the signal peptide region that suggests handling as a lipoprotein, but this Cys is not well conserved.	5.08556e-29
NZ_CP044513.1\|WP_000099245.1\|3362968_3363727_-\|indole-3-glycerol-phosphate-synthase	gnl\|CDD\|140013	PRK13957, PRK13957, indole-3-glycerol-phosphate synthase; Provisional.	3.19133e-169
NZ_CP044513.1\|WP_001181792.1\|3371095_3371854_-\|biotin--[acetyl-CoA-carboxylase]-ligase	gnl\|CDD\|223417	COG0340, BirA, Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism].	2.12937e-35
NZ_CP044513.1\|WP_000559675.1\|3374991_3375852_-\|acyl-[acyl-carrier-protein]-thioesterase	gnl\|CDD\|238329	cd00586, 4HBT, 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).	2.4573e-10
NZ_CP044513.1\|WP_001021444.1\|3367183_3367429_+\|DUF1563-domain-containing-protein	gnl\|CDD\|203693	pfam07599, DUF1563, Protein of unknown function (DUF1563). A small family of short hypothetical proteins in Leptospira interrogans.	3.46457e-16
NZ_CP044513.1\|WP_001007304.1\|3357150_3357987_+\|hypothetical-protein	gnl\|CDD\|372640	pfam13588, HSDR_N_2, Type I restriction enzyme R protein N-terminus (HSDR_N). This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.	2.42454e-07
NZ_CP044513.1\|WP_002117956.1\|3358342_3360079_-\|glycosyltransferase-family-39-protein	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	5.2274e-40
NZ_CP044513.1\|WP_000928025.1\|3370320_3371094_-\|type-III-pantothenate-kinase	gnl\|CDD\|237347	PRK13318, PRK13318, type III pantothenate kinase.	3.31134e-115

>NZ_CP044513.1|WP_000671562.1|3364148_3365540_+|UDP-N-acetylmuramoyl-L-alanine--D-glutamate-ligase
MKFPESLKGLKILVLGGGISGNSALNFLISEKAQPILCDRNQPERTVVPFFPDNIPSQSLPEVSLVIKSPGILPTHPILSYAADKKIPVVSEIDLGRYFFKGKTIGITGTDGKSTTTSLIAHLLKESFPDLKEGGNLGIPFTSFCKESISLAVLELSSYQLEDSSPLHLDVSVFLNLASDHLERHKTMENYFQAKLKIADLSNSNHTLIVSEKIKERILNSISYQCKLLSFGKTSDSNAFLDENSLKIKTSKFVYDISKFYLPGTHNRENLAASILAAEEIGGKPESIQTRIPLFRGLPHRFQIAGEKLGISFINDSKSTNLHSMLAGMATWKNIDQTCLILGGRPKQEDLKPLYNFLIKGIGCVVLFGEARATWESGIKNIIGEKLYCVENLNNTFEIFKKGNVFPVPGLNKDIIIRLSDSISISSFVFSPACASFDQYKNFEERGNHFLSLVNDFLDQIDS
>NZ_CP044513.1|WP_000884017.1|3363733_3364066_-|STAS-domain-containing-protein
MLDHKVRDGVLIVYLKGRLDVSIANEVEENLNDLIDNQGHKKVILNMQEVDYMSSSGFRACISTLRKLNSKEGALKISNIKPAVKRIFDVIELTSLFDICETEDEALKSF
>NZ_CP044513.1|WP_000099245.1|3362968_3363727_-|indole-3-glycerol-phosphate-synthase
MSSSQPHRVLREIISTKQNEIKKISAWDPLPHRGLSLRDSLKSRTFSIIAECKRKSPSAGELRADYRPVQIAKTYEELGASAISVLTDQNYFGGSLEDLKDVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPEQIKSFLKLASSLGMDCLVEVHTSDEAKLALDCGAEIIGINTRDLDTFQINQNLVKEVSAFLPPNIVKVGESGIKKRSDLDTFRKLVDAALIGTYFMEKQDIRKAWLNLF
>NZ_CP044513.1|WP_002064352.1|3361387_3361702_+|hypothetical-protein
MISESSFRVLPFNGIFSVWFSEIINDLLGRFFFSSLERILFSNYKFITKNNLSLQIYVFCASNVSSKLELRYANFIEKRLFYLELKVIKRLQIWAKIRKLICKF
>NZ_CP044513.1|WP_000622612.1|3360408_3361458_-|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MISENQTEKIPLKGRTLKELSEIMITLGEKPFRAKQIYHGLYVNRYETWDQFTTFSKIFKEKLEELCSLTHLQVVKQLKSVDGTQKFTFTSESGNGKEFEAVWIPSGDGGRKTICISSQIGCTLNCKFCATAKLEFQGNLKAHEIVDQILQVEKIVGDKATNVVFMGMGEPLHNYFNVIRAASIFHDPDALNLGAKRITISTSGVVNGIRRFIENKEPYNFAISLNHPDPKGRLQIMDIEEKFSLPELLQAAKDFTRELKRRITFEYVMIPGVNMGSENANKLVKIAKSLDCKINVIPLNTEFFGWRRPTREEIAEFIALLEPAGVPILNRRSPGKDIFGACGMLASKS
>NZ_CP044513.1|WP_001068430.1|3360093_3360378_-|Cys-rich-protein
MNPKRTIILFLYLLPFVSCQEYVQQKCNSACKFFVQCAMNDFKHVKVTELEKNQMMIDCESGCIREQGFVLPCFESETTCKGFNTCVMESGFMD
>NZ_CP044513.1|WP_002117956.1|3358342_3360079_-|glycosyltransferase-family-39-protein
MNQISVDNKQPISVRILFIFLIVSVLPLILTLPLDMIDIDSSQYAEISREMVEGGNPFFIRDNGRRYLDKPILTFWKISLSFLIFGYQNFAFRLPALLFTFFSFWGIFKLTELYSESRLRAWISVFLYALSPGLYSMVVDPKIDVYLTPYLILVHTFYYLGFKRNQNYYYLMYFAMGLGFITKGPIAMVIPSISIGGDILFRRDWRRLLKMKLFPGVLLAILPPLLWSIPLYLEFQTYGPYFFLWIQSFGRFYVKMYNQKFNPLFFYSNFSWAFGVFILPFFGFVFDRIVTFLKQNKGKEVFQNILKNKYFNLDFVIGFWLFLFLFLISFSRYQLPQYIYWCLPAAAVIGSGVLESILLSLKDQKNKSWFNKLNQGLFLVTAVVFLIAVLVIPWISVEVSWSYLILPLVYLGVFLWVFFKSSTIGRLLAFWIFSASLFFSIVSLYLYPMLTSFQPSKEIGIWIRKYEPNKDKLFLFGVPASKRSYAYYSRRISRTLFDPAVLIDSVQKDGQRYLIVQDKWLPKLEEFFGNNLQFETVKEFPSYKVATPEGKFFLKSHRDQIVGKVILMRASRKDFQKK
>NZ_CP044513.1|WP_001007304.1|3357150_3357987_+|hypothetical-protein
MAIPTKIFERISSGVKKFQPILTSAKTRDVNESDTVVIITDLLSEVFGYDKYSEITTEHVIKKTFCDLAIKIDGKVKLLIEIKAIGLELKDDYIRQAIDYGANSGIEWVILTNGMNWQIYRITFSKPIDKEMVYEINFSNINPKIENHIEPIYYLCKEALGKSLLDEYHSQKQALSKYYIGQMILTETVLDVIKRELKRLTPGVKIENDEIEEVLRSDIIKRDILEGDKAVDAKKKIQKAANNYLRNSSPAPKKENMPSTVNETETQKNLLNEEISLN
>NZ_CP044513.1|WP_001024698.1|3356927_3357140_+|hypothetical-protein
MNINNAVDKPYEAKKLLEIADSPVSALQGLSEGDADYLLKAFNVKTVRDLANLKYVKWAQSIIALADTEQ
>NZ_CP044513.1|WP_100221011.1|3356024_3356369_-|hypothetical-protein
MKGNDAGKLSRTLFQTKASRFLNSMQRLPESRSLERHSLNFPGLLKQLKRFTSMVTRQIVFYNKLKSVKDFVFKQILNLLIVRPATPVRPNFIKSNSHYLNVKLLNYILFYSPE
>NZ_CP044513.1|WP_001021444.1|3367183_3367429_+|DUF1563-domain-containing-protein
MNIILIGFFLLETLENLYTAYVEYFLKQTFLDSIQKISKTDRKQNEIPVLPIFKILIFQVISSKGIFLSLSDNKINQRYKL
>NZ_CP044513.1|WP_000092395.1|3367795_3369691_+|DUF1561-domain-containing-protein
MSRWIVLLLVLLISLGVGYSYGVNPDVVPISSSDIPGAIIQRPTDKPKDKPIKIIVHDGGTFCYGPTFSGGESYIVIEQCWEQDVRNARYDVFQRISYNINDTWLCITVPESVVKGETNWDYVHLKPCTINDPLQRWIVKENSFWTADERYRLKDYNWYAYISKNSGDYYNHTLDSSMSDWINTVATPGNISILTSIAWNLGSNRYFIRSGGSDKNTTPIYYNPESGHLAQYNPESGSLYCMYSRVGSYNWNWVTWESCNDASISKDNPAYWNVYLATEEGGMIMDYQGNALRVTRYGSNWGVAYTAKLSYLKKDTTYSPTSLFIVDRDLLNWVRYTASNLGKTDQYCPAGKKESRTKRVKRTLPSDFQLTEEWTRRLYDIAISTITNPQVSGICGVCLLHTFQMLAELQEYHSREPLQSGGYFFDTAPNRDPFISFRQRYPELDSSLAHIPRVYNSASTTLRLLTLVSAMNMMPLYDWTPSREFTTRPEMLSHITSLIGSPAGSIWLALMRRQRPDGTIAGHAVPILRTSEGLVVIPTRIPSSISLELYRQYLTPTMDPIQAINNLEQPDRTLRYFVTIQLGEFYHNFTDLVISNRNCTGEGEGRRGTGEYPTSATVNQCSEGRCALPNQ
>NZ_CP044513.1|WP_000928025.1|3370320_3371094_-|type-III-pantothenate-kinase
MLLVVDVGNTNTVFGIFENGNKIPLFHKRTVTRKDRTSDELGLFFRGFLREFKIENEMITGGIYSSVVPTLNPILDRMFQDWFKIEAIRVHYQMKLPFSISYPRPYEIGADRLVNAATCAIDFPGKSIIIDLGTATTFCVVNEKPEYLGGVIAPGLKVSMDALTRNTSQLPPIVFQSPGKILGDSTIESIQAGFFFGWIGLLEGIIREIKKDKGQDYQVIGTGGLVTVIDAAHPGIFDKIDPLLTLRGLQILHLMNS
>NZ_CP044513.1|WP_001181792.1|3371095_3371854_-|biotin--[acetyl-CoA-carboxylase]-ligase
MQNVLLQPEKGIFLDSVTSTNTVIKGKEFPHGTWIVAEEQTAGRGRKDRTWEVFGEESLIFSGKIGLENFDAGPGLSLFIGTAVCKTILSVYPELTREIKIKWPNDLYRGNKKVAGILIESEIEGSFMTLIIGVGLNLYGKNESIPNHLTDAGFLNTNPNRAGKKNEILEKLVPFLNESILLWKDIEGRKKELILLNELLLWKGQSVRYKENGQLQTGILEGLSENGSLILKTPSGTRLDFIDSPEDFHSLN
>NZ_CP044513.1|WP_001187394.1|3373178_3373370_-|hypothetical-protein
MQQQYLVGIFLATEQRKFALGINFHLDDVEVGVPEMLWTYVCGLVPNSRSIVVKRYYNQDPRL
>NZ_CP044513.1|WP_000778965.1|3373629_3374955_-|thiolase-family-protein
MKLTKPLAICTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEIACITVANNCVSGMEAVAEAARRIVLGEGEVFLAIGEESQTSMPFVVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLEDGLGDGETSYGMQVTAEIVAQNYGLSREIQDKLAFESFKRALEASKAGKYSPYIIPMKDDEGNELTIDEAVGLREGLVENPTRMGRAMLMFDNPGMKFEEFKTKYSKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVVSGWHMKGVHPNNMGIGQAVATKALLDETGIKIQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKINPNGGSIAIGHPFGATGIRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERYKG
>NZ_CP044513.1|WP_000559675.1|3374991_3375852_-|acyl-[acyl-carrier-protein]-thioesterase
MIADEIQLVTRISDLDTQRHVTSRTYENFCLEGRFRTLEKNGFSIREILSQGIKIHPLESQIRFLAQQMEGASLKTKTKAFPLKDGKIFWDQKVLSDTGTIAAEIKTLTFSEKDGHPIDLLPLEKTEMSGFDQFPQIPDFRGTCKTVDTSMITLYSERNIFGEYNPAYLWRIVEDSRWFFSTETGLTLDRFVEMDTTLFFMGGVFRFFHPVPAGRKIKVSTWIHSFEKIRSYMRHEVTDIETGLRYFAVQDEQLVVSLTKSRPKKAPDEFQQLVGDYVENFEYSKK
>NZ_CP044513.1|WP_000885366.1|3375911_3376112_+|hypothetical-protein
MAFPHICLWGDSDPSLDEAKFRSNKKNRTFVLFFYINYPKSLTEDFSDGKMNLKKSVTFLYENSTA
>NZ_CP044513.1|WP_000856977.1|3376092_3376707_+|TetR/AcrR-family-transcriptional-regulator
MKTQPRKKKESGTGVRERILDTATSLFYKQGFSSTGMRQIIQESNSVAASLYDHYPSKKELGLAYLARQEEKTLSDLQSLMDRYPDLGEFLRAWVILKEKQIRHGEFVGCPFAGFASQVMDSDPEYTEFLKDIVNKWIRMISDYLQKAIGSGQLKRSMDIQYVARRILMAYHGSITMWRMTQELRFIREMDDSLREIVEEYRIL
>NZ_CP044513.1|WP_082268216.1|3377071_3377380_-|hypothetical-protein
MIITFVITSKLEAIGFSFLLLPFYFPSIILLILVKLNMFDKWYAKLSFLYPILMVDCLFMGNFIYDIYHPSNDGSSQMLVLVSSILNVPIPFLYLIHKYVLK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: NZ_CP044513_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044513_12

4133982-4134077

Orphan

Consensus_repeat	Method
GGAAAACTCAGCACAACGCTTTCCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044513_12

>merge|NZ_CP044513|12|4133982-4134077|CRISPRCasFinder
GGAAAACTCAGCACAACGCTTTCCTCAAACTCAATGCATCGCTCCCTAAGGGTCGCTCTGCAGGTCGCGTTGGAAAACTCAACACAACGCTTTCCT

>NZ_CP044513|12|12|4133982-4134077|CRISPRCasFinder
GGAAAACTCAGCACAACGCTTTCCT	CAAACTCAATGCATCGCTCCCTAAGGGTCGCTCTGCAGGTCGCGTT
GGAAAACTCAACACAACGCTTTCCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044513.1\|WP_000644925.1\|4127114_4127537_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000008116.1\|4142835_4143645_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999
NZ_CP044513.1\|WP_061294273.1\|4136804_4138397_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|223910
NZ_CP044513.1\|WP_000055092.1\|4139944_4141378_+\|SidA/IucD/PvdA-family-monooxygenase	unknown	unknown	gnl\|CDD\|109787
NZ_CP044513.1\|WP_000020274.1\|4147947_4148778_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl\|CDD\|185333
NZ_CP044513.1\|WP_001284345.1\|4134789_4135791_-\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491
NZ_CP044513.1\|WP_000353570.1\|4127917_4128448_+\|DUF1564-domain-containing-protein	unknown	unknown	gnl\|CDD\|284922
NZ_CP044513.1\|WP_000121284.1\|4144298_4145162_-\|S-methyl-5'-thioadenosine-phosphorylase	unknown	unknown	gnl\|CDD\|350161
NZ_CP044513.1\|WP_000499820.1\|4130780_4130987_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000218834.1\|4123079_4124081_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_CP044513.1\|WP_000033741.1\|4139106_4139556_+\|redox-protein-OsmC	unknown	unknown	gnl\|CDD\|224678
NZ_CP044513.1\|WP_000837582.1\|4131195_4132818_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|334197
NZ_CP044513.1\|WP_000200407.1\|4128536_4130369_-\|DNA-mismatch-repair-ATPase	unknown	unknown	gnl\|CDD\|213250
NZ_CP044513.1\|WP_000043663.1\|4145802_4147371_-\|methyl-accepting-chemotaxis-protein	unknown	unknown	gnl\|CDD\|214599
NZ_CP044513.1\|WP_001167091.1\|4130365_4130602_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044513.1\|WP_000671771.1\|4141485_4142817_+\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|277335
NZ_CP044513.1\|WP_000472897.1\|4133243_4133729_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226352
NZ_CP044513.1\|WP_001116784.1\|4125009_4127091_+\|AsmA-family-protein	unknown	unknown	gnl\|CDD\|282957
NZ_CP044513.1\|WP_000580060.1\|4148958_4149732_-\|cobalamin-binding-protein	unknown	unknown	gnl\|CDD\|238564
NZ_CP044513.1\|WP_000619183.1\|4124077_4125031_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226967

Protein	Function_ID	Function_description	E-value
NZ_CP044513.1\|WP_000055092.1\|4139944_4141378_+\|SidA/IucD/PvdA-family-monooxygenase	gnl\|CDD\|109787	pfam00743, FMO-like, Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.	2.3593e-85
NZ_CP044513.1\|WP_000008116.1\|4142835_4143645_+\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	1.73446e-12
NZ_CP044513.1\|WP_061294273.1\|4136804_4138397_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|223910	COG0840, Tar, Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms].	6.439e-31
NZ_CP044513.1\|WP_001284345.1\|4134789_4135791_-\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NZ_CP044513.1\|WP_000353570.1\|4127917_4128448_+\|DUF1564-domain-containing-protein	gnl\|CDD\|284922	pfam07600, DUF1564, Protein of unknown function (DUF1564). A family of paralogous proteins in Leptospira interrogans. Several have been annotated as possible CopG-like transcriptional regulators (see pfam01402).	2.63413e-90
NZ_CP044513.1\|WP_000121284.1\|4144298_4145162_-\|S-methyl-5'-thioadenosine-phosphorylase	gnl\|CDD\|350161	cd09010, MTAP_SsMTAPII_like_MTIP, 5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP). MTAP catalyzes the reversible phosphorolysis of 5'-deoxy-5'-methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1-phosphate. This subfamily includes human MTAP which is highly specific for MTA, and Sulfolobus solfataricus MTAPII which accepts adenosine in addition to MTA. Two MTAPs have been isolated from S. solfataricus: SsMTAP1 and SsMTAPII, SsMTAP1 belongs to a different subfamily of the nucleoside phosphorylase-I (NP-I) family. This group also includes Pseudomonas aeruginosa PAO1 MTI phosphorylase (MTIP) which uses 5'-methylthioinosine (MTI) as a preferred substrate, and does not use MTA. NP-I family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.14038e-133
NZ_CP044513.1\|WP_000043663.1\|4145802_4147371_-\|methyl-accepting-chemotaxis-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	5.04126e-36
NZ_CP044513.1\|WP_000218834.1\|4123079_4124081_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.74236e-143
NZ_CP044513.1\|WP_000020274.1\|4147947_4148778_-\|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	8.3073e-53
NZ_CP044513.1\|WP_000837582.1\|4131195_4132818_-\|hypothetical-protein	gnl\|CDD\|334197	pfam00656, Peptidase_C14, Caspase domain.	8.69787e-16
NZ_CP044513.1\|WP_000200407.1\|4128536_4130369_-\|DNA-mismatch-repair-ATPase	gnl\|CDD\|213250	cd03283, ABC_MutS-like, ATP-binding cassette domain of MutS-like homolog. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal domain with a conserved ATPase activity that belongs to the ATP binding cassette (ABC) superfamily. MutS homologs (MSH) have been identified in most prokaryotic and all eukaryotic organisms examined. Prokaryotes have two homologs (MutS1 and MutS2), whereas seven MSH proteins (MSH1 to MSH7) have been identified in eukaryotes. The homodimer MutS1 and heterodimers MSH2-MSH3 and MSH2-MSH6 are primarily involved in mitotic mismatch repair, whereas MSH4-MSH5 is involved in resolution of Holliday junctions during meiosis. All members of the MutS family contain the highly conserved Walker A/B ATPase domain, and many share a common mechanism of action. MutS1, MSH2-MSH3, MSH2-MSH6, and MSH4-MSH5 dimerize to form sliding clamps, and recognition of specific DNA structures or lesions results in ADP/ATP exchange.	3.84933e-91
NZ_CP044513.1\|WP_000033741.1\|4139106_4139556_+\|redox-protein-OsmC	gnl\|CDD\|224678	COG1764, osmC, Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism].	1.18655e-20
NZ_CP044513.1\|WP_000671771.1\|4141485_4142817_+\|alkaline-phosphatase-family-protein	gnl\|CDD\|277335	cd07389, MPP_PhoD, Bacillus subtilis PhoD and related proteins, metallophosphatase domain. PhoD (also known as alkaline phosphatase D/APaseD in Bacillus subtilis) is a secreted phosphodiesterase encoded by phoD of the Pho regulon in Bacillus subtilis. PhoD homologs are found in prokaryotes, eukaryotes, and archaea. PhoD contains a twin arginine (RR) motif and is transported by the Tat (Twin-arginine translocation) translocation pathway machinery (TatAyCy). This family also includes the Fusarium oxysporum Fso1 protein. PhoD belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.70361e-52
NZ_CP044513.1\|WP_000472897.1\|4133243_4133729_+\|hypothetical-protein	gnl\|CDD\|226352	COG3831, COG3831, Uncharacterized conserved protein [Function unknown].	0.0037807
NZ_CP044513.1\|WP_001116784.1\|4125009_4127091_+\|AsmA-family-protein	gnl\|CDD\|282957	pfam05170, AsmA, AsmA family. The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant. AsmA may have a role in LPS biogenesis.	5.80516e-09
NZ_CP044513.1\|WP_000580060.1\|4148958_4149732_-\|cobalamin-binding-protein	gnl\|CDD\|238564	cd01144, BtuF, Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	3.0312e-90
NZ_CP044513.1\|WP_000619183.1\|4124077_4125031_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226967	COG4608, AppF, ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism].	4.41237e-127

>NZ_CP044513.1|WP_000472897.1|4133243_4133729_+|hypothetical-protein
MFKIYYLVSKNNPLEFWNLEITENSFTVISCDKADLHTETEETQVFETNEICFQKAEKLLREKLNSGYQEVAPKTLQRIDRLEDQLGSLAMKYRACDLGSEEEKKIISEYHKILNILFQRDLIHFWSQRPDHDSCLPDELMPKFYRDHRDRQIGKRNRLQN
>NZ_CP044513.1|WP_000837582.1|4131195_4132818_-|hypothetical-protein
MKSKLSAIVICSILFFATDAFAQKRYGLIFGTNYTGNKAGIPELNLCEADASYLNDEIRKVGNFDEVKIVLGKEVTKDNIEKEIKALAKKAGDNDTVLLYFSGHGAFQRDASAKNGMRNLIICYDRPHLPDDELNKYLEKIKSPKTVFIFDCCFSGGIAKKGKSTRGSADVPIPEGSNGTVKQDAEDFFFQDKAIISSADDNQTAIEVGGSINHGIFTYNFGRALGSADLNKDNVVTALEAFFKSKEETVQMAKKFQHEQVPQISGNASGIFLSGKKNPEPPKPVDPPKPPAPSAEPEPDPVKPDPSQPVVTPEEPPVVPTNERGDLVLKTTIIQDRAYGLSDLPPDILIFAKKKRKGNRNVKVYIDDQEFSSTVTATSSNFWGAVKRQGQLIPGNIYTITLSKVPAGVHKITIKADDYPEIQETFAVLPNKKNELPINVSMSGFGAIQGKVFYKTLDNPVSNQPIFMPTISSVTGIQKLNTDSEGNFWFTNLKPGDYEIKASFAEDLNLNNSMINVREGDVTKVDVILNVKMPSTKTKY
>NZ_CP044513.1|WP_000499820.1|4130780_4130987_+|hypothetical-protein
MFYPEMDPDLKSSFLSIDKTVANLINNTILPEAGLKAGNLLNANQMKKLKEIRKRRFRSNEWKNFLKD
>NZ_CP044513.1|WP_001167091.1|4130365_4130602_-|hypothetical-protein
MQIRMINNTGRRTGRFVTYEYGTDLFGYVYVDKIKGKDRGKLVSRWVMPDLGSLVRLLDFEIYKRENEHYENISSVIG
>NZ_CP044513.1|WP_000200407.1|4128536_4130369_-|DNA-mismatch-repair-ATPase
MTSFTRIDRLKRRAEKLNKLHDKISVLLSRLSLFRLIFFSVFLLWISIFYYLRSSIFYHLPSLVFLFLFFFFVRRYKKTLSTRKKIQLWIFVLERESARISIKGFGKKFGTQIFLEKVSPLARDLDLFRENGLFSWLDTTFTSNAEQKLIALLDLEDSSSYNNRENVLLRQSIVRSISEKILAIPKILRLASYLKENQDVFQARTKTETKSIRDENTSKFWESYPWLKKIYRPITILVLAFIPANVFLGVPFPASVLFLNLILFGLYRSRSLDIFRQYYSISGSISGLQKILIYLKGLKIRDKNGRFLLEDTSKDELRSAYKDLDLILKRVSLTEAPLLHLILNNLFLYDLWVLQKISKWKEKHSVLLEKSIEDLTLFDSLFSFANLKWMFPDYCFPEILSENSKEGISGKGLFHPLIPSDSRVSNPLDFIEEQNVVLITGSNMSGKTTYLRTIGVASILSMAGGPVPASKFSLPVLKIHTSMRNEDNLEEGISFFYAEVRRLSEIVKKIRDKNSSHLVLLDEILKGTNTRERSLACKGILKELKKNRAIVFVTSHDLELAKVEGVILKHFQEEVLDGTMYFDYKIREGLVETSNALRILVQEGLDLDFT
>NZ_CP044513.1|WP_000353570.1|4127917_4128448_+|DUF1564-domain-containing-protein
MDILLFDDGQKIESALVEGSIGTDSLLVPNNYWNCLNFQERKTLRGKLPILLRKYSKQIASMKRLHYKAGKIKYNRDVGKMKKFSVRVHTGVWATLGVLAAAHGVSRCYLFNYMLWLEELGEEENFFVKTLNQGVPSFHWTYKMIWKIDRRQNLISRELKFEPNPMTNQYPYYLRS
>NZ_CP044513.1|WP_000644925.1|4127114_4127537_+|hypothetical-protein
MKAKLFIRIASALMLVFTLGHSFGHFTRYETSDPQALSTISIMQQTKIPMEGVTKTYDQFYTGMSLNLSVVLISLTVLLWILSNFSESNPQAVQKLLIPTLFCISCFGITGFIYFFLIPAVVASLGAFSILVGIVLLGKN
>NZ_CP044513.1|WP_001116784.1|4125009_4127091_+|AsmA-family-protein
MPFSNRLDLMKFFKRIQEFLYTYRIRFLAIILIQIIAVISFTLVPLLIREDFYKDFILTAIEQKTGLEVKVGSSDLVLFPFPGIELKEVQIRKEELVIGISDRIKVDISWFGLLGQKVEIRDVYISGGKINLHKNKDGSVDLIEFFQQDTEDSENSNHNHTIRIFDPSSTVESSSFISPKEIFKVGLKNVEIENFYIHYQDDTHRKTYEIYLSNSALNISFYGNNFVLTLQGKLDGQSFQIYGSTNLDEFPTTYENSKFQSTISLDKCSLSIFRDLLTIFPNADFSKTILNGTIKIDKVPNRSINFNVIAQAKNFAYKGGNPFGDIKVNMEFRLDLPNKKLEFPYISILWPGIAEGNAKGTVLWNYKTNVSFQVTANYLDYHSALRLGKLFEFTKKFDDPNRPNGVFYFSVDLKNVYALKHRIPVLKAELKYSYPWIHIPSFHAYIYNGEILGKSKIDPFTSKFEVQGEAYRIQSDRILMPYVNDPIINGDMFSRFNFVTEVHNRSSDFTTEFFRNMEGSGNLQVLNGELLGYANFMIPVLNTLGKIISFNGIDGRKVEFSSLKSDFTIENNHLHFQNLKLQGKGLEADGKGNISFEKNIDVLINLRLGGNIVGRVLKIPIIYKGVFKQSIPYIDPIWLGSVFAGSTILAPFFTFAGGPYGGGIAGSVVSEYVRDAWEGLKGLFSSKEDKKKK
>NZ_CP044513.1|WP_000619183.1|4124077_4125031_+|ABC-transporter-ATP-binding-protein
MIRIENLTISYYTKSGFGLKKSRIVAVDSVNLEIGKNEIIGLVGESGCGKSTLGRGLVKLLKPEFGSIYFEGKEITSLSSSEFFPFRKNIQIIFQDPYSSLNPRMTIAEILMEGLEIYEKTSREEAETKIKKILEKVNLSSDILSRFPHEFSGGQRQRIAIARALVLKPKFVICDESVSALDVSTGTQVLKLLVELKNEFGLSYLFISHDLGVVKSISDRIAVMYLGKIVELGNTKNIVSSPAHPYTKALFQSTFDVYDRKKNRIPLKGEIPSIVNKPTGCHFHTRCPIARDLCKSEVPVWKEIRNGQKVLCHFPID
>NZ_CP044513.1|WP_000218834.1|4123079_4124081_+|ABC-transporter-ATP-binding-protein
MTVSSLLQVKNFSLDLLSENQWLPVLQNLNFEVKSGEILSLIGESGCGKSLTSLALTKLVPSNISKVKSGEILYQGKDLLKLSLEELRKLRGKEIAYIFQEPFAALNPLLKIQDQMIEAYLMHVSQNRKEAIEKAEFLLASVGITDIQQRLGSYPNQMSGGILQRISIAMALMCDPSLLIADEPTSAIDVTIQAQLVELLLNLQKQNRMSILFISHDFGLVGTIADRIVVMYAGRIAEIGDTDSVIDSPNHPYTKDLLKSIPSLAKSVEDLQPIQGIVPSPNQYPLGCHYSTRCQIAIDSCKESKPDLFPILQSDLKPHLSACFLAKDPDKSS
>NZ_CP044513.1|WP_001284345.1|4134789_4135791_-|ketol-acid-reductoisomerase
MANIYYDADCDLNSLKGKTIAVIGYGSQGHAQAQNMKDSGLKVIIGLKEGSKSIQDAKNAGFEVYSVSEASQKADIIQILAPDTIQADLYKKDIEPNLKKGDALVFSHGFNIHYDFIKPPKEVDVYMVAPKGPGHLVRRVYTEGGGVPCLIAIYQDSSGEAKKRALAHAAGVGGGRAGILETSFREETETDLFGEQVVLCGGLSNLIMAGFETLTEAGYDPEIAYFECLHEVKLITDLIYEGGLARMRFSISDTAEYGDYVSGPRVIDPGVKQRMKEVLNDIQKDKGAKFATNWMAETKAGYPNFKNMRDKNASHPIESVGKKLRSMMKWLSK
>NZ_CP044513.1|WP_061294273.1|4136804_4138397_-|methyl-accepting-chemotaxis-protein
MPLKKETKRKTDEEIIASGPTYINWIRFGLILLFYISILINWKRTNSIQNILYLSGTTAMFLNFIYSFYKIRKTGSISHTLSKVFLLVDVLVQLVVMMGATMDHPDFTTGVVKSPILYGISYMYIVSSGLLLVPNFVLWIGFLSGGAQALAIFTATRYGLILTEQKKLANSLGYASVSEQITKILFVFACAVIVRILVKLFMRLRENSRYRQEALEESHKLIAQRSSKMKESAQYLKDSSKNLKSFMDDLSVLVSTQASSFEEISSTVEQFQSQTENSSYNVKNQFRNIESLILHSNNLKSIIEKISNFNQTLDQSMDKVRKSGTMVTKFVEELSGSLSSLGDSFRSVGEVNRIMSEVADRTNLLSLNASIEAARAGEAGRGFAVVAQEVSKLAESSAGNADLISKIIRDSSNHVQMGRESAETTAGHVKEQDTLIQDLFVRFDEFSNLFYEQRKINSEFFSTLDRLRSLSSEIELASSEQKMGLQGIVEAISLLQNSMESLVTKSENLSVVVRELETQSDTLILAETNT
>NZ_CP044513.1|WP_000033741.1|4139106_4139556_+|redox-protein-OsmC
MSKHKISLSWKKGLEDFKYDSYDRTHSIQYEGGQKLHGSSTPETYGKAEHTNPEELLASSVCSCHFLTFLAIASKSRHIVSNYEDNAIATLEKNEEGKMVVTKIELYPKVTFEGDKIPDLDTLVDLHEKAHKNCFIANSIKSKVIIQPR
>NZ_CP044513.1|WP_000055092.1|4139944_4141378_+|SidA/IucD/PvdA-family-monooxygenase
MSLLPTVCIIGAGPSGIAVCKALKDKGIPFECYEAGSEVGGNWKFKNDNKMSSIYKSLHTNTHKDKMQYKDYPMPNSYAAYPDHQKISEYFINYVNHFGFRDHIFFKTPVTHVKHEEDGTWSILTEDGKQKYYDVLIVSNGHHWSQRWPKPDFPGKFTGDIIHSHSYIDPNKPIQLTGKRVVILGMGNSAMDIAVELCRPGISSKVFLAARRGAYIIPNYLFGKPLDKIATLFPVHTPFWLKSLIIKFALKLGVGNVEDFGLQKPDHKPGAAHFTISQDILVRLGRGDIIPKPNIESYNGNKVKFVDGSEEEIDVIIYCTGYDVKFPFFDENFLSAKDNHLPLFHRMVKPEFKNLFFVGLFQPLGPIAPLSEFQGKWISEYLVGNYEFPSEEKMNQSIEKYESKMKRRYITSARHTMQVDFEVFLYDMKSELKKGIKRAAKNGNKLPVPALAQNKSILSNDISVKRFKNKTELFSEI
>NZ_CP044513.1|WP_000671771.1|4141485_4142817_+|alkaline-phosphatase-family-protein
MKFQISKYKTIFYFFSLFFNHILNAESAKIVSGPILGYSTLKEVLVWVQTDQKSNVKLEYSEIGNSKNKLFSEEIQTKLEQGFIAKLIANQVEPGKKYNYNILIDGKKIPAKHSQVFQTQPFFTYASNEDPPSFSFALGSCSYINEPEFEVPGKTYGGEYFIFNLILSKKPNFMLWLGDNIYLREPDWDSRTGFFHRYRQQRGIPELAPLFASVHHYAIWDDHDFGPNDADSSYWMRETSEEMFKLHWGNPNYAKEGIYGSFIWGDVQFFLLDNRTFRTANNNKMISPRQILGEKQFQWLVNSLAYSKATFKFIAMGGQFLNPNPIFENYATYLEEKNKILSAIQDLKVKNIIFLTGDRHFTELNFLKEKDISIYDLTVSPLTSKPYSPDSEKNPLRVEKTLVDKRNFGTISISGKRNERKLVLQIFDVYGKELWKKEILSNP
>NZ_CP044513.1|WP_000008116.1|4142835_4143645_+|alpha/beta-hydrolase
MSFIITFLLSFIFLILFLIWWNQERLIFFPEKLSENFIFHFPNEFKEIKLTTPDGEKSYGLFFPSKNNLSKKTILFFHGNAGSLRTWGRIYEDFLPIGWNLLITDYRGYGKNSGSISEESMNSDAELWLSYLLNEIKIPRNEIVIYGRSIGTGVAIDLVSKNPDLNLFLETPFIDLFTLARNYYPFIQAWMLKFQFQNLAKLKNIRSKIRIFHGTQDPIIPYSNSEIIFKKLKEQNQDVILFTISNGSHNDLTIYPEYHRALKNSLDEL
>NZ_CP044513.1|WP_000121284.1|4144298_4145162_-|S-methyl-5'-thioadenosine-phosphorylase
MSYNVRAAIIGGTGLYSLEGMELIEEIFPDTPWGKPSDKIKIGKYKGKLIAFLPRHGIGHFLSPPEVPNHANICALKQLGVEEIVAFSSVGSLREEIKPLDFVLPSQIIDRTRFRNSTYFGNGVVAHAPFAEPFSPNLSKRIAQTAKKIGLEIHLDKTLVCMEGPLFSTKAESHLYRSWGADIINMTVLPEAKLAREAEIAYQMICMSTDYDCWREGEESVTVEMVIANLTKNAETAKKLLSELIHVLGNGDDLSLKNSTRYSIITAPEKRNPETVKKLRVLFPEYF
>NZ_CP044513.1|WP_000043663.1|4145802_4147371_-|methyl-accepting-chemotaxis-protein
MSKQSIESIRKKGEALTYYSRMTIMVMVLISLAASFKTLQIQIKIIHSSAAFFMFVYTLFGFILYKKYEIKQWVHNLFIIFDSLILSVTIFLDSMVSPELISPVLKNAILYSVYYFIIAYSGLLGRPKFVLITGMFCYFGYSIALTNAAFHGLRFSEDNTINMKPGYVKLSAEITKIFFMAGVSLILYRLMNLFDELYQEASSYFQENKDFLNKLENNRKIIHSSAETLELSVTNFSEFTSLTSEKMESQAASLEEVNAVITSLSKSSEKNADSIRIQNENLIELNQKAQTLLEVIAEISDHSKGLDVNAKESKTEMKVVKESVEKTGEFLKNISNSFQRVDEINRILGEIADKTNLLSLNASIEAARAGSAGRGFAVVAQEVSKLAEFTATNAKMIAKVVQESLEFIEEANTASQGTGHLTENQSIKVNLTVSKIEEMSRLYERGTTIVNDFVKNLERVKKLSDDLFHSTEEQMTAQKEMMKAMFELEKEVNEITQESGRIQDGVLQIKTQSRDLKALSIV
>NZ_CP044513.1|WP_000020274.1|4147947_4148778_-|methylated-DNA--[protein]-cysteine-S-methyltransferase
MSHYQKIAEAIQFIQKNAISQPELDEVAKSVNLSPFHFQRLFTEWAGVSPKQFLQYITLQNAKSILSKPQTTLFDAAFETGLSGTSRLHDLFVKIEGMTPGEFKNGGENIKIRYSFQRSVFGNYLIASTEKGICNLFFYDISEEQIVSELKEQWNRADIIEQMDENQNRVIRFFDKTLNGHEKIKLHLKGTEFQIKVWEALLKIPEGQLSSYSDIADLIGQENASRAVGTAIGKNPIGYLIPCHRVIKSTGGIGEYRWGSERKMAMIGWEASKVKI
>NZ_CP044513.1|WP_000580060.1|4148958_4149732_-|cobalamin-binding-protein
MIGPKRIICLTEETTELFYLLGIEERIVGISAYTVRPLRAKKEKPKISAFINGNIKRIKELKPDLVIGFSDIQSDLAKNLIAEGLNVLVTNQRTILEIFDTLSLLGSIVGKGNETQKLIEGWKRKLDEIERVYSSKSQPSVFFQEWDEPIITGISWVSELIKLAGGKDCFEHLKTKSLAKDRIISAIDVAKANPEVYIGSWCGKPMNFEWVQKHPDWQNVSAILNHKVYELDPSIILQPGPALFEEGIDQLVKLIHS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP044513_12	12.1\|4134007\|46\|NZ_CP044513\|CRISPRCasFinder	4134007-4134052	46	NZ_CP044513.1	3644055-3644100	0	1.0
NZ_CP044513_12	12.1\|4134007\|46\|NZ_CP044513\|CRISPRCasFinder	4134007-4134052	46	NZ_CP044513.1	3644125-3644170	0	1.0
NZ_CP044513_12	12.1\|4134007\|46\|NZ_CP044513\|CRISPRCasFinder	4134007-4134052	46	NZ_CP044513.1	3644196-3644241	0	1.0
NZ_CP044513_12	12.1\|4134007\|46\|NZ_CP044513\|CRISPRCasFinder	4134007-4134052	46	NZ_CP044513.1	3326919-3326964	1	0.978

1. spacer 12.1|4134007|46|NZ_CP044513|CRISPRCasFinder matches to position: 3644055-3644100, mismatch: 0, identity: 1.0

caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgtt	CRISPR spacer
caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgtt	Protospacer
**********************************************

2. spacer 12.1|4134007|46|NZ_CP044513|CRISPRCasFinder matches to position: 3644125-3644170, mismatch: 0, identity: 1.0

caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgtt	CRISPR spacer
caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgtt	Protospacer
**********************************************

3. spacer 12.1|4134007|46|NZ_CP044513|CRISPRCasFinder matches to position: 3644196-3644241, mismatch: 0, identity: 1.0

caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgtt	CRISPR spacer
caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgtt	Protospacer
**********************************************

4. spacer 12.1|4134007|46|NZ_CP044513|CRISPRCasFinder matches to position: 3326919-3326964, mismatch: 1, identity: 0.978

caaactcaatgcatcgctccctaagggtcgctctgcaggtcgcgtt	CRISPR spacer
caaactcaatgcatcgctccctaaggatcgctctgcaggtcgcgtt	Protospacer
**************************.*******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP044513_5	5.3\|3121208\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121208-3121242	35	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	403-437	0	1.0
NZ_CP044513_5	5.4\|3121279\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121279-3121313	35	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	53917-53951	0	1.0
NZ_CP044513_5	5.4\|3121279\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121279-3121313	35	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	26368-26402	0	1.0
NZ_CP044513_5	5.8\|3121566\|37\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121566-3121602	37	NZ_CP011933	Leptospira interrogans serovar Manilae strain UP-MMC-NIID LP plasmid pLIMLP1, complete sequence	65216-65252	0	1.0
NZ_CP044513_5	5.9\|3121639\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121639-3121673	35	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	46706-46740	1	0.971
NZ_CP044513_5	5.9\|3121639\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121639-3121673	35	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	33360-33394	1	0.971
NZ_CP044513_5	5.11\|3121784\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121784-3121818	35	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	7368-7402	1	0.971
NZ_CP044513_5	5.12\|3121855\|35\|NZ_CP044513\|CRISPRCasFinder,CRT	3121855-3121889	35	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	7368-7402	1	0.971
NZ_CP044513_6	6.1\|3122118\|35\|NZ_CP044513\|CRISPRCasFinder	3122118-3122152	35	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	29236-29270	1	0.971
NZ_CP044513_6	6.2\|3122189\|39\|NZ_CP044513\|CRISPRCasFinder	3122189-3122227	39	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	51224-51262	1	0.974
NZ_CP044513_5	5.6\|3121420\|36\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121420-3121455	36	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	33258-33293	2	0.944
NZ_CP044513_5	5.9\|3121639\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121639-3121673	35	NZ_CP039285	Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence	46916-46950	2	0.943
NZ_CP044513_5	5.9\|3121639\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121639-3121673	35	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	33570-33604	2	0.943
NZ_CP044513_9	9.1\|3123198\|36\|NZ_CP044513\|CRISPRCasFinder	3123198-3123233	36	NZ_CP006727	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence	51384-51419	4	0.889
NZ_CP044513_5	5.4\|3121279\|35\|NZ_CP044513\|PILER-CR,CRISPRCasFinder,CRT	3121279-3121313	35	MN694421	Marine virus AFVG_250M313, complete genome	4052-4086	9	0.743

1. spacer 5.3|3121208|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 0, identity: 1.0

gatctcagtccgttgataaactcaattacggaatt	CRISPR spacer
gatctcagtccgttgataaactcaattacggaatt	Protospacer
***********************************

2. spacer 5.4|3121279|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 0, identity: 1.0

caagagaaaaaggataaagacggaaaccggttttt	CRISPR spacer
caagagaaaaaggataaagacggaaaccggttttt	Protospacer
***********************************

3. spacer 5.4|3121279|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 0, identity: 1.0

caagagaaaaaggataaagacggaaaccggttttt	CRISPR spacer
caagagaaaaaggataaagacggaaaccggttttt	Protospacer
***********************************

4. spacer 5.8|3121566|37|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011933 (Leptospira interrogans serovar Manilae strain UP-MMC-NIID LP plasmid pLIMLP1, complete sequence) position: , mismatch: 0, identity: 1.0

gctgctgacactgttattataccagtaataccggagc	CRISPR spacer
gctgctgacactgttattataccagtaataccggagc	Protospacer
*************************************

5. spacer 5.9|3121639|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 1, identity: 0.971

atcatgcgaatccggtgggaacgttgctggtttat	CRISPR spacer
atcatgggaatccggtgggaacgttgctggtttat	Protospacer
****** ****************************

6. spacer 5.9|3121639|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 1, identity: 0.971

atcatgcgaatccggtgggaacgttgctggtttat	CRISPR spacer
atcatgcgaatcaggtgggaacgttgctggtttat	Protospacer
************ **********************

7. spacer 5.11|3121784|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.971

ccacgaaacagatacaaagccttctatttttccct	CRISPR spacer
ccacgagacagatacaaagccttctatttttccct	Protospacer
******.****************************

8. spacer 5.12|3121855|35|NZ_CP044513|CRISPRCasFinder,CRT matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.971

ccacgaaacagatacaaagccttctatttttccct	CRISPR spacer
ccacgagacagatacaaagccttctatttttccct	Protospacer
******.****************************

9. spacer 6.1|3122118|35|NZ_CP044513|CRISPRCasFinder matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 1, identity: 0.971

atacaaagttccgagtcgaatcgggatcactgaat	CRISPR spacer
atacaaggttccgagtcgaatcgggatcactgaat	Protospacer
******.****************************

10. spacer 6.2|3122189|39|NZ_CP044513|CRISPRCasFinder matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 1, identity: 0.974

agtatggctatagcggttttggtttctttttttattttt	CRISPR spacer
ggtatggctatagcggttttggtttctttttttattttt	Protospacer
.**************************************

11. spacer 5.6|3121420|36|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 2, identity: 0.944

ttcctgggcctggtatgtttatattatcaggggatg	CRISPR spacer
ttcctggccctggtatgtttatactatcaggggatg	Protospacer
******* ***************.************

12. spacer 5.9|3121639|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP039285 (Leptospira interrogans strain FMAS_AW1 plasmid pLiSL2, complete sequence) position: , mismatch: 2, identity: 0.943

atcatgcgaatccggtgggaacgttgctggtttat	CRISPR spacer
gtcatgggaatccggtgggaacgttgctggtttat	Protospacer
.***** ****************************

13. spacer 5.9|3121639|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 2, identity: 0.943

atcatgcgaatccggtgggaacgttgctggtttat	CRISPR spacer
gtcatgggaatccggtgggaacgttgctggtttat	Protospacer
.***** ****************************

14. spacer 9.1|3123198|36|NZ_CP044513|CRISPRCasFinder matches to NZ_CP006727 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp3, complete sequence) position: , mismatch: 4, identity: 0.889

agttgactctgcaaaacttttgcctcaaattcagga	CRISPR spacer
atttgactctgcaaaacttttgccgcaaattcgaga	Protospacer
* ********************** *******..**

15. spacer 5.4|3121279|35|NZ_CP044513|PILER-CR,CRISPRCasFinder,CRT matches to MN694421 (Marine virus AFVG_250M313, complete genome) position: , mismatch: 9, identity: 0.743

caagagaaaaaggataaagacggaaaccggttttt	CRISPR spacer
gaaaagataaaggataaagacggaaatctaactat	Protospacer
 **.*** ******************.* . .* *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

985077 : 994468

Leptospira_phage(66.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001092810.1\|985077_986466_-\|transposase	IS4 family transposase	Q9JMP3	Wolbachia_phage	6.4e-72	33.0
WP_029762730.1\|986952_987777_+	hypothetical protein	S5W9A4	Leptospira_phage	2.9e-104	69.3
WP_001011221.1\|987843_988980_-	hypothetical protein	S5W9G5	Leptospira_phage	4.2e-13	62.9
WP_001011509.1\|989181_990252_-	hypothetical protein	S5W9G5	Leptospira_phage	1.2e-09	63.3
WP_100225687.1\|990409_991557_-\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	3.7e-41	34.9
WP_082271590.1\|991715_992693_-	hypothetical protein	NA	NA	NA	NA
WP_002116245.1\|993058_994468_-	hypothetical protein	S5W9G5	Leptospira_phage	4.3e-07	59.3

DBSCAN-SWA_2

1687490 : 1696940

uncultured_marine_virus(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000575181.1\|1687490_1688582_+	DegT/DnrJ/EryC1/StrS family aminotransferase	A0A2P1ELT3	Moumouvirus	4.0e-37	34.0
WP_000600954.1\|1688724_1689522_+	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	3.5e-06	35.6
WP_000282882.1\|1690032_1690854_+	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	7.1e-10	30.0
WP_000853988.1\|1691579_1693328_+	glycosyltransferase	A0A0F7L2F7	uncultured_marine_virus	7.7e-06	33.3
WP_001159758.1\|1693524_1694085_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.5e-45	52.9
WP_000642147.1\|1694088_1695009_+	dTDP-4-dehydrorhamnose reductase	NA	NA	NA	NA
WP_000723081.1\|1695005_1696055_+	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	1.3e-93	51.2
WP_000842260.1\|1696055_1696940_+	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	4.8e-97	60.3

DBSCAN-SWA_3

3027301 : 3100318

Mycobacterium_phage(25.0%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000577238.1\|3027301_3028426_+\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	1.7e-78	43.1
WP_000406878.1\|3028496_3028832_+	STAS domain-containing protein	NA	NA	NA	NA
WP_000843319.1\|3028879_3030547_+	lipoprotein LipL71	A0A0A7RVP5	Clostridium_phage	9.6e-06	54.2
WP_000878128.1\|3032081_3032969_-	alpha/beta fold hydrolase	A0A218MNI3	uncultured_virus	1.9e-05	28.6
WP_082271583.1\|3033460_3034408_+	SAM-dependent methyltransferase	NA	NA	NA	NA
WP_001119612.1\|3034498_3036778_-	TonB-dependent receptor	NA	NA	NA	NA
WP_000665701.1\|3038213_3039107_-	EAL domain-containing protein	NA	NA	NA	NA
WP_128915938.1\|3041538_3042346_+\|transposase	IS5 family transposase	A0A0M5M147	Mycobacterium_phage	6.3e-27	33.0
WP_001068400.1\|3042428_3043112_-	response regulator transcription factor	NA	NA	NA	NA
WP_000588669.1\|3043115_3045728_-	sensor histidine kinase KdpD	W8CYF6	Bacillus_phage	1.2e-18	29.5
WP_000576697.1\|3045724_3046297_-	potassium-transporting ATPase subunit KdpC	NA	NA	NA	NA
WP_061294256.1\|3046307_3048386_-	potassium-transporting ATPase subunit KdpB	E4ZFI9	Streptococcus_phage	5.7e-40	28.3
WP_000255832.1\|3048396_3050070_-	potassium-transporting ATPase subunit KdpA	NA	NA	NA	NA
WP_017858602.1\|3050079_3050169_-	potassium-transporting ATPase subunit F	NA	NA	NA	NA
WP_000405261.1\|3050315_3055511_-	SpoIIE family protein phosphatase	NA	NA	NA	NA
WP_000791167.1\|3055711_3057775_-	NAD(P)-binding protein	NA	NA	NA	NA
WP_000656256.1\|3057871_3058795_-	hypothetical protein	NA	NA	NA	NA
WP_000394095.1\|3060038_3060458_+	hypothetical protein	NA	NA	NA	NA
WP_139325166.1\|3061008_3061816_+\|transposase	IS5 family transposase	A0A0M5M147	Mycobacterium_phage	8.2e-27	32.6
WP_000483729.1\|3062131_3063193_-	hypothetical protein	NA	NA	NA	NA
WP_000562954.1\|3063194_3064163_-	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A1B1IUU3	uncultured_Mediterranean_phage	9.2e-09	35.5
WP_000844443.1\|3064233_3065754_+	peptidase M14	NA	NA	NA	NA
WP_000468416.1\|3065753_3066659_+	DMT family transporter	NA	NA	NA	NA
WP_000255342.1\|3066784_3067060_+	hypothetical protein	NA	NA	NA	NA
WP_000729236.1\|3067853_3069008_+	taurine dioxygenase	NA	NA	NA	NA
WP_001156910.1\|3069012_3069921_+	bile acid:sodium symporter family protein	NA	NA	NA	NA
WP_000013216.1\|3069904_3071008_-	rhodanese-related sulfurtransferase	NA	NA	NA	NA
WP_000345335.1\|3073238_3074420_+	AraC family transcriptional regulator	S5WIW9	Leptospira_phage	3.7e-36	31.5
WP_151419845.1\|3074529_3075670_+\|transposase	IS3 family transposase	U5P429	Shigella_phage	5.2e-43	37.4
WP_000063748.1\|3076424_3077636_+	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_000620707.1\|3079698_3080661_+	porin OmpL1	NA	NA	NA	NA
WP_001079907.1\|3080764_3081715_-	cytochrome-c peroxidase	NA	NA	NA	NA
WP_128915924.1\|3082142_3082340_+	hypothetical protein	NA	NA	NA	NA
WP_011172145.1\|3082965_3083163_-	hypothetical protein	NA	NA	NA	NA
WP_000284122.1\|3083140_3084304_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
WP_082268740.1\|3084251_3084524_+	hypothetical protein	NA	NA	NA	NA
WP_016689547.1\|3084483_3084582_-	hypothetical protein	NA	NA	NA	NA
WP_001071494.1\|3084578_3085751_-	CoA transferase	NA	NA	NA	NA
WP_000499940.1\|3086185_3087262_+	hypothetical protein	NA	NA	NA	NA
WP_001166988.1\|3087778_3088165_-	cation transporter	NA	NA	NA	NA
WP_000944884.1\|3088242_3089076_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_000906009.1\|3089591_3089885_+	hypothetical protein	NA	NA	NA	NA
WP_000744497.1\|3089930_3092264_+	TonB-dependent receptor	NA	NA	NA	NA
WP_000759966.1\|3092274_3092649_+	hypothetical protein	NA	NA	NA	NA
WP_000512027.1\|3093192_3093729_-	DUF1564 domain-containing protein	NA	NA	NA	NA
WP_100225687.1\|3094905_3096052_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	3.7e-41	34.9
WP_000182246.1\|3096985_3097396_+\|transposase	transposase	NA	NA	NA	NA
WP_000841648.1\|3097749_3099117_+	SidA/IucD/PvdA family monooxygenase	NA	NA	NA	NA
WP_139325160.1\|3099509_3100318_-\|transposase	IS5 family transposase	A0A0M5M147	Mycobacterium_phage	1.4e-26	32.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP044516

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP044513

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection