CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP044534	Lactobacillus frumenti strain LF145 chromosome, complete genome	3 crisprs	DEDDh,RT,cas3,DinG,csa3	0	0	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP044534_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044534_1

1252873-1253142

Orphan

Consensus_repeat	Method
TCAAAGTAATACCANTTA	CRT

4 spacers

The CRISPR arrays of NZ_CP044534_1

>merge|NZ_CP044534|1|1252873-1253142|CRT
TCAAAGTAATACCAATTATTATTAATCCACTTCCAACCAGAATAAGCCCATGCGTTATTTTGGTCAAAGTAATACCAATCACCATTAAGTTTTTGCCAACCGGTTATTGCCCAAGTGTTTAAGGTATCAAAGTAATACTTATTATGATTAATAGTTTGCCAGCCGGTTACCGCTTCACCATTACTGTCAAAGTAATACCAGTTGCCAGCGCCTGATTTGAACCAACCGGTTTGTGCCCATGTATTTAGGGTATCAAAGTAGTACCACTTA

>NZ_CP044534|1|1|1252873-1253142|CRT
TCAAAGTAATACCAATTA	TTATTAATCCACTTCCAACCAGAATAAGCCCATGCGTTATTTTGG
TCAAAGTAATACCAATCA	CCATTAAGTTTTTGCCAACCGGTTATTGCCCAAGTGTTTAAGGTA
TCAAAGTAATACTTATTA	TGATTAATAGTTTGCCAGCCGGTTACCGCTTCACCATTACTG
TCAAAGTAATACCAGTTG	CCAGCGCCTGATTTGAACCAACCGGTTTGTGCCCATGTATTTAGGGTA
TCAAAGTAGTACCACTTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044534.1\|WP_057752354.1\|1240759_1241869_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NZ_CP044534.1\|WP_083482719.1\|1252312_1252432_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274741
NZ_CP044534.1\|WP_057752309.1\|1264224_1265943_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|287142
NZ_CP044534.1\|WP_083482720.1\|1241982_1243809_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224619
NZ_CP044534.1\|WP_057752336.1\|1250008_1252285_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP044534.1\|WP_057752342.1\|1246115_1247522_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|181811
NZ_CP044534.1\|WP_057752328.1\|1256772_1257279_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224346
NZ_CP044534.1\|WP_057752312.1\|1263370_1264228_-\|UbiA-prenyltransferase-family-protein	unknown	unknown	gnl\|CDD\|260126
NZ_CP044534.1\|WP_057752319.1\|1259670_1260711_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044534.1\|WP_057752303.1\|1267023_1268601_-\|peptide-chain-release-factor-3	unknown	unknown	gnl\|CDD\|179105
NZ_CP044534.1\|WP_057752339.1\|1247569_1249846_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP044534.1\|WP_057752325.1\|1257310_1258597_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP044534.1\|WP_057752345.1\|1244159_1245899_-\|SEC10/PgrA-surface-exclusion-domain-containing-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP044534.1\|WP_057752331.1\|1254816_1256403_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370572
NZ_CP044534.1\|WP_083482718.1\|1265942_1267007_-\|acyltransferase-family-protein	unknown	unknown	gnl\|CDD\|225813
NZ_CP044534.1\|WP_151495798.1\|1239597_1240686_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP044534.1\|WP_057752348.1\|1243921_1244128_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP044534.1\|WP_057752315.1\|1260924_1262811_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227588
NZ_CP044534.1\|WP_057752300.1\|1268693_1270190_-\|carnitine-transporter	unknown	unknown	gnl\|CDD\|376718
NZ_CP044534.1\|WP_057748804.1\|1239029_1239413_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224639

Protein	Function_ID	Function_description	E-value
NZ_CP044534.1\|WP_057752354.1\|1240759_1241869_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	4.56027e-61
NZ_CP044534.1\|WP_083482719.1\|1252312_1252432_-\|hypothetical-protein	gnl\|CDD\|274741	TIGR03715, cell_surface_protein_precursor, KxYKxGKxW signal peptide. This model describes a novel form of signal peptide that occurs as an N-terminal domain with a recognizable motif, reminiscent of the YSIRK and PEP-CTERM forms of signal peptide. This domain tends to occur on long, low-complexity (usually Serine-rich and heavily glycosylated) proteins of the Firmicutes, and (as with YSIRK) the majority of these proteins have the LPXTG cell wall-anchoring motif at the C-terminus.	9.20554e-06
NZ_CP044534.1\|WP_057752309.1\|1264224_1265943_-\|hypothetical-protein	gnl\|CDD\|287142	pfam10131, PTPS_related, 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein. This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	8.79363e-10
NZ_CP044534.1\|WP_083482720.1\|1241982_1243809_-\|hypothetical-protein	gnl\|CDD\|224619	COG1705, FlgJ, Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion].	8.13514e-48
NZ_CP044534.1\|WP_057752336.1\|1250008_1252285_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.57441e-23
NZ_CP044534.1\|WP_057752342.1\|1246115_1247522_+\|transcriptional-regulator	gnl\|CDD\|181811	PRK09379, PRK09379, LytR family transcriptional regulator.	6.02915e-81
NZ_CP044534.1\|WP_057752328.1\|1256772_1257279_-\|hypothetical-protein	gnl\|CDD\|224346	COG1429, CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism].	0.000123695
NZ_CP044534.1\|WP_057752312.1\|1263370_1264228_-\|UbiA-prenyltransferase-family-protein	gnl\|CDD\|260126	cd13963, PT_UbiA_2, UbiA family of prenyltransferases (PTases), Unknown subgroup. Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.	5.31087e-92
NZ_CP044534.1\|WP_057752303.1\|1267023_1268601_-\|peptide-chain-release-factor-3	gnl\|CDD\|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
NZ_CP044534.1\|WP_057752339.1\|1247569_1249846_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.5398e-21
NZ_CP044534.1\|WP_057752325.1\|1257310_1258597_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.68513e-21
NZ_CP044534.1\|WP_057752345.1\|1244159_1245899_-\|SEC10/PgrA-surface-exclusion-domain-containing-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	5.10152e-27
NZ_CP044534.1\|WP_057752331.1\|1254816_1256403_-\|hypothetical-protein	gnl\|CDD\|370572	pfam09586, YfhO, Bacterial membrane protein YfhO. This protein is a conserved membrane protein. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	0.000456575
NZ_CP044534.1\|WP_083482718.1\|1265942_1267007_-\|acyltransferase-family-protein	gnl\|CDD\|225813	COG3274, COG3274, Predicted O-acyltransferase [General function prediction only].	1.36267e-06
NZ_CP044534.1\|WP_151495798.1\|1239597_1240686_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	3.4597e-14
NZ_CP044534.1\|WP_057752348.1\|1243921_1244128_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	6.96716e-08
NZ_CP044534.1\|WP_057752315.1\|1260924_1262811_-\|hypothetical-protein	gnl\|CDD\|227588	COG5263, COG5263, FOG: Glucan-binding domain (YG repeat) [General function prediction only].	1.31132e-18
NZ_CP044534.1\|WP_057752300.1\|1268693_1270190_-\|carnitine-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	1.10812e-112
NZ_CP044534.1\|WP_057748804.1\|1239029_1239413_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	1.49402e-27

>NZ_CP044534.1|WP_083482719.1|1252312_1252432_-|hypothetical-protein
MSIKKHYKLYKAGKQWCTAAIATMAVFSRPFFRAKIHCG
>NZ_CP044534.1|WP_057752336.1|1250008_1252285_-|hypothetical-protein
MKQHYKIYKSGKLWITACILTLGLLSFTGTANAQTENMETSTPQNEQRTQPVNKAQHVTSINGYTEKNGQWQSSDGQLANGWQTDQNNWYYFQDGQNSSSWKWINNNWYYMNPDSHIMETGLQNINNATYYLNEQHDGTYGAMKTGWQNVNNNWYYFANNGSARTGWQWLDHNWYYFDPTTSIMQAGLKQINNKGYYLNDQHNGAFGAMMNGWQNINGKWYGFGGPSDGSALTGWHYINKNWYYFNNNGEARTGFQTINGHQYYFDPTNAWALRGWQSLNNDWYYFDPSNVWALSGWQNLNGWFYFSPESYKSLNGLQTINNHLYYLNDQHDGTFGMMKTGWQNVNGNWYYFNSNGDALSGWQTITGYHYYLNPANYQMMTGIQKLDNNYYFFGPSGNQETGLVYNSTTGLLQYYDPSTGTRQISAMLNGQTLTFNSTTGDLDTTNITNGLVLLGNNRYFFLKNSNRFDANDWQKINGSWYYFGSNAAATTGWYKSAAGNWYFFNPDGTARTGWQSINGHWYLFDALNANAITGWYKSNAGFWYYFDPTNAWADTGWTFVNHNWYYMDPTNANMYTGGHWINGHWVNLQSNGAFVGFSQRVINWFLAREGKLTYSMYGSRTGADGTADCSGSMTQAVWSAGGRTPAHTYSTLDLGRYLLQNGYYIAGYGRGVQNVQYGDIVIWGTPGASAGGVGHTVVISTAGPDPMCISTCGYYWSENPYSHYGAAGKAVQEFNYQWYWNEDDRPYQMVYRPNFYWA
>NZ_CP044534.1|WP_057752339.1|1247569_1249846_-|hypothetical-protein
MKEHIKLYKSGKLWVSALVAALTVTIGVGTAFANDNVTNNEPTAQLTANNDVASTMPDSINGYVKHNQNGNVTYQNDAGQNLTGWQNANNSWYYFDDNGSAHTGWYQSPAGNWYDFKENGQAQSGWYQSQAGAWYYADPTNAWNLTGWQNLNNNWYYFDPIQTWARTGWQWINDNWFYFDPTNHGQMLTGIQRIDNQTYYMNEQHDGTYGAMKRDWQYVDGHWYDFDNGGAAHQGWLLTPFNNWYYFNQQGQAQTDWYQVNGHWYYGDLTNAWTLRGWHWLSDGWHYFNPNQTWLDENWQWLDNSWYYFDPANHGLMLTGFRQINGQHYYFNEQHDGSYGAMKTGWQWINDGWYYFTDSGSQLFSWQNINGTTYYLDPTTGLMATGDTIIDGNHYYFNLSSGAQEKGMLLNPMTGKLNYYDEQSGIRQTSVDGYTFNSVTGDINTDNLTNGLNTIYGHVYFYNKASDRFASNEWKQINGSWYYFNDNGVAPTGWFKSNAGNWYYFNNNGAAKTGWFQSPAGFWYYFDPTNANATTGWRYINNNWYYFADGYECQHGTGAWVRTDNNYGQMYTGVQWVDGHCYNFGASGAETAEPWNDWWSWPFPSSGEGYFLPGQAFGYSSYPRKNHYHDGLDFGVSDHPGYEVHAVHGGKVLDVTTCDDDNGQPMWWYVTIWDGKYLYVYQEAFSNRNKIAVSPNDIVYPGQVIGWRDLSHLHLGINTSPNYEMDLNHSFQPSWYDSNAATGSGYWLNPETVIRNHG
>NZ_CP044534.1|WP_057752342.1|1246115_1247522_+|transcriptional-regulator
MNDNHESREEYRRKLEKRIQAKVQEDEANEKPSSSSKFGWHKRTRKQRPDTHYQPSAKSVQIPKVHHYRTPRWVKDIIWAIVILLLIGGGYEYHKIHSAASNIFGNGNGQISKKLQKGEPVSVLAMGTDVGALTRGNTGGNTDSLELFTINPKTKRITMTSIPRDTLVRVNTKDGPDYVKINAAYALGGPKKTVKQVSELLNVPIDYYAVLNMGVLKKVVNTVGGVTVDNPFAFTYEGHHFKKGKQHLNGELALKYSRMRYSDPNNDYGRQKRQQQIIESVIHKFKASGSIGTANKMIDAVKDGVKTNIPIDDIATLYGNYHAAMNSVTTYHFKGQDATIDGVSFQIASPKEINRISKLVRKELGLKYKKVTNHETKMYKSQPLYDGVVHTDFILPGGASYNDPGSGNGSDYVTGSSHHKAKSSTINTNPYDSTSPYEEPRYEQRTVPSTNGIRARAQYQTPRRIFAY
>NZ_CP044534.1|WP_057752345.1|1244159_1245899_-|SEC10/PgrA-surface-exclusion-domain-containing-protein
MQRSAQLIALTVMTTALGIIASDYNVKADATEPTTQTVQVTTNTNQSYDLYSNQLVNIHNDVRYGEQSIYLPAGFTLQNITNVDDSASAQALQNQVKKPGLENNNYMSNQQAAQEQIEINNLTNDQVTQMNQYALGLVNQVRYELGVEPFGQNQGSINAVKGMALQYQDKNESLLNGSWHDASILQNHSENISSFQIYDDHIAGLGFKSFAAAKGKDFEDDHSVPLFSVETMDDLRAMIYYGVMGMLFYDAHDTFGHAKNFLTYYQPVKNMGVYPSIVAQTNHSGRYSNGQQFDFQVADVDMHFIWANQDTNSHWQNNGGKWSYIFVTKTGNGDGQETTNQANATGIQHINGNTYYFDNSGVMQTGWQLLNNHWYYFQDSGAAATGWQWINGHWYFFNNAGVADTSWGKVNQRWYFFDPINAWANYGWQYLSGVWYYFDPTNAWMQTSWQSINHYWYYFATDSGKMMTGIVPINNDWYYLDSNGAMQVGWWNINGHWYLFNQDGSGVKNWYRSAAGNWYFFNQYGYAQTGWYQTAAGNWYYFDPYNAWAQKGWFWSGANWYYFDPINAWALKGLSMLKW
>NZ_CP044534.1|WP_057752348.1|1243921_1244128_-|hypothetical-protein
MDHGWQLIDGHWYYFNVSGQMLSGLVWINGRLYFLNPYHDGSFGAMLTGQHNVNGRTLSFDSTDGWLI
>NZ_CP044534.1|WP_083482720.1|1241982_1243809_-|hypothetical-protein
MTYLFEEEYKLVHRNLAKFNQIKKGLLMTTAVLSGALLFGVHSAHADELSSSTTNSANISTTNVNTIPENINGYVKQGLVNSAWENSNGQLLNGWQTVGSDWYHFSNGTPSTGWQSIDDNWYYMNQNSAKMEVGLQNINNQTYYLNEQHDGTYGAMKIGWQYLNNHWYYFQSNGAAQTGWADINNAKYYLDPNTAQMATGDTEVSGLHYYFDPSSGHQIKGMVFDNASGKLSYYDDQTGIRKEVYSGQANSISNWAGQHQTSELKEGLNVINGQEYYYDSKTKRFVSNEWKQINNKWYYFGQNGQATKDWYKSAAGNWYYFTDNGSAQTGWFKSKAGCWYYFDPTNAWAQKGWFKSAAGLWYYFDPQNVWAKTGWFWSGYNWYYFDSTNTWADTGWQYINNKWYYFDKTNAWADTGWQLIDGAWYYFKSSCAMAANEAFTDGSKSYEADVWGHTHEISGHAAFLASIKQAALDGWRTYGVLPSVTAAQAILESAWGQSRLATEGHNLFGIKGSYNGQSITMRTAEYGGGGYYYINAAFRRYQSNYESVVDHGRFLAVNSRYHNLLWNRNYRDVTAKLQYDGYATAPTYAASLNNVIVANGLAAWDSEI
>NZ_CP044534.1|WP_057752354.1|1240759_1241869_-|AI-2E-family-transporter
MNKQKYYHWLFWPSVLLVIATLIFVCTKIQFVFKPFLTFISVIFVPLIISGFLYYMLNPILKLLMKVRIGRFQMKKGIASLLIVAVMILIVLWGIASLIPPVVKEITQLVNHLPQTVSGLQGLLNDTVKHSPLKHVDMTTYYKQFDHQLAAYAQKILKGLSGRVGDIIGVVTNVTVVTITVPVMLFYMLKDGSKLAPSIQKWLSPHHAKEVSDLLGKMNDTLSSYIAGQVIECLFVGVFTSIGYLIIGEPLALVLGIAAGLCNLIPYVGPYIGIAPALFVALTMAPDKLIWVIVVVIVVQQIDGNIVYPNIIGRSLKIHPLTIICLLLAAGHIAGVGGMILCIPFYAVVKTVVEYMFDIYRIEHPVEKN
>NZ_CP044534.1|WP_151495798.1|1239597_1240686_-|hypothetical-protein
MRNRKYWLISASVLLGLVCGSGMVHADSNTAINNQPNATNVTNVVTTQSTTANVNVTTTQNGNSSTNVNVSEQPSSVMSNASAQTDAQKAAYYSSGWHEQNKQWTYSKDDGTEAEDEWLWIDNAWYYFDGPIMAANGWHGTKLADGSWKDYYFDQWGHYMTNTWHVYNGSWTYSKDDGTAAEDQWLWINGYWYYFDSEVMAANGWHGTKLADGSWKDYYFDQWGHYMTNTWHVYNGSWTYSKDDGTAAEDQWLWINGHWYYFDSEVMAANGWHGTKLADGSWKDYYFDQWGHYMTNTWHVYNGSWTYSKDDGTAAEDQWLWINGHWYYFDNEVMVSNGWHSTKLANGSWKDYYFDQWGHMIY
>NZ_CP044534.1|WP_057748804.1|1239029_1239413_-|GntR-family-transcriptional-regulator
MQFHFDESSPLYQQIASQLEEMIFTGGFDEGDKVPSTTQLSQQLHINPATVLKGMNQLVDKGLIEKRRGLGMFVMKGAQQKIMEQRKEDFYNDYVKTLLLEAHKLGITKQHLQDLIERGEQDGKINS
>NZ_CP044534.1|WP_057752331.1|1254816_1256403_-|hypothetical-protein
MQRFKPIYWQYYLLFFLNALIIFILIFRQGIICGWDLQFHLNRIEELHYSLLSGHLLASNGSFTFSKIGLAVSTFYPYLFLYPFAIMRSLINPVIAYNVCLFFLTLLSFIVSYKAINNFPSQNRHTESGDLGFLFSLIYNNSGYLLLQFTQRGDIPEYIALIFLPLLLMGLLSLLKQPNSKKWLWMPITFVFIVYSHLLSAFIFTLFIIVILCLNYRQLDKIKLKKLLLSGVIILGCTLPITLNIIISNHNNKIVAPIVPDTLQNEALKSNDLLINSLANLVPGPLSTVNLGFVVLICTFISLFILRGYNSLGRQLAVIGLFALILSTNLFPWFIFQHTPLHIIQFPWRFLGIATFCIAYDASWVLQPLINKRGILFLIFITINFITFNYIHNYVHNGNQIIAYKQIRQYRKMATDAVYTDYMPEQTLTGMDKATYFRKKSDIHRHVAVINGHKVKLFQQQIKPGYNRISYTLTSLKPDRINYVTLPLLNYGNNHASHGITAKQTSRGTTMIAFIPKSDKQVVTIYLH
>NZ_CP044534.1|WP_057752328.1|1256772_1257279_-|hypothetical-protein
MPKKLLTLFAAGAMTMALAACGNENTTSHKSADHARSEKVVKHSSSVTKSESSAITASSQSGSTTTSSKNAAANYSVAKSNGATSSKVKSNQTASTRSPMTAQDAKDIVKEHLLAVINDAGINGKPKPNVPSMDEIDSYTTTQNGMNDWTVSGNGHTYHVTATSVTEE
>NZ_CP044534.1|WP_057752325.1|1257310_1258597_-|hypothetical-protein
MEKKRFKLYKSGKQWLSMALVAVASLTLGMTMATIDGQADASIQNDTVVTTQVADQNIQQSANATTSMATASQTTAGNTTTGVNQADNSASNGEVKPTTTGLVQRNNSTYYYNANSQSYVTNTWENVNNSWYHFGDDGSATTGWYQSQAGLWYYFQNTGVAQTGWFKSQAGLWYYFNSTNAWADEGWQNINNNWYHFDETNAWATTGWYKSNAGNWYHFDETNANATTGWYKSQAGLWYHFDETNAWANTGWFKSQAGLWYYFDPTNAWADTGWQSINNVWYYFDPTNAWMLTGTQTINGKTYHFNADGSWADDHSAAVAKAMSVRGTAYVWGGNNPSTGFDCSGLVQWAYGLGSNYRTTYTQQTLGAHHYDVANAPKGSLLFFGSDSAPYHVAISLGNGAYVHAPQPGDVVKVGYTKYYAASYYVVL
>NZ_CP044534.1|WP_057752319.1|1259670_1260711_-|hypothetical-protein
MNHKVTYEGIDCLKVVAAIGIVAIHTHVPLFETIGRLGLPFFSIVTSFFFFKHYLRLNSHDDRKHYLKKFEVRLLWLYGLWQIIYLPLAVKNSYSFFRTNGCHVFSFFKYIFDLLFKLWPSNVNGWFPSWYIIGMIIALPFSLFVYKYVFRKNKYLYGMFCIVLEIYFVLCSELGFLRLIKLELINSDSFPRLIIYIFIGYLLAKNLNTVKGYNLSKVSILMCVLIICYYLENLIVSHLGGCLSNDETILTMPTSLVIVIFSIIYIPRINEVQSESLRRFSTFLYCFQAWSLAVFDYLNSNKFHITSFTTTAVMDFIFVMITACVAFFIYDYVARATHWKFWNYMV
>NZ_CP044534.1|WP_057752315.1|1260924_1262811_-|hypothetical-protein
MNNEHVHSYKLRNTILLASVALTLGIFASTTNTYANDKTPVVKTTTNNNKPNTDAANPTPTASTLDTTYASAKAAIDATSTESEANSVASQQKEQETKAISDYYVSQKSAKSAALAQEYNAKSAQFTKEYTSDEAAVSAGNSLTIKGIKDAYDTAIQANQAASAAQKGYEDLSNAVVKDQEAVKEAQKEVDEASAAVKPAKGKDQNKEQDSKADNSDNDALVLAKGKLKTAQDQLKSDQDALTKAKSKLDEAKKGVVDVAAIAWKYLTDLKSTNDATLAKLKEENQKILNQYDTDASAEISHMNTVIDGYLDNHVKQFNIDTPTGKANTWGEQKSKDGKISWYYYGKNGKAVQGWNLIGDDWYYFAKSNAEMFAGIKTINGKVYYFNPNHDGTFGRLLTGWQKVNGSWYWFAGDEDTKNNIHGGYAKTSWQKTTPANNWYYFDDNGKAVTGWFKSPASGLWYYFDPVNAWAVTGWFRSGAGHWYYFDPVNAWADTGWQSINGHWYYFDPTNAWATKGWYRSNAGNWYYFDPVNAWAVTGWFRSPASGLWYWFDQDNAWMVTNGWGFNHDNGQRYYFDAAGHPMTGWLKSYDGTWYYFQPGSDAALANGRYWIGGRQYSFGATGNWLQY
>NZ_CP044534.1|WP_057752312.1|1263370_1264228_-|UbiA-prenyltransferase-family-protein
MRDYIKLMRPFHWVKNLLIFVPLFFSGRLFTSNKITDLIIAFLAFSLIASSVYVLNDIKDADKDRLHPKKKYRPIASGHISKAHALMLWALLIVISICLMALLVRVIDSFYAALSLPIVYMLINVLYSNGLKNVPLLDVAIIAAGFVIRLYYGAVVCGILISDSLLLTVISASFFLGFGKRRNELKKGTSTRKVLQAYNIHFLDKIMYVFIGLTLVFYSLWTITRGNNLVYTVPFSMLIVADYCLIIESNSSDGDPAEVLKHSKTLMCLLVLFVVFMFICLYVNP
>NZ_CP044534.1|WP_057752309.1|1264224_1265943_-|hypothetical-protein
MENSKRQIWLNITMYALFIALSIIYIWPFAHRGVIFGSGDLMFHVNRMEELYQDIQHGVFIPRISAFSFNQVGSGINFFYPWLLLYPFVILRLITNNPVSAFYIGIVLMNFLTLSVAYYSMLKFSFSRKRSFAFSIIYSFANYRLYLVFNQNVLAEALAYTFMPLALLGFYEIFFHDNHKWPLLALGMTFLIYSHMLTTALIALFLLGTLVIFWHFIDHKSQRFCSAIKAAFLALSLSAFYLLPFIEQTLSNNLVASWKGLEFVQTPSDTILKSLNNSPYQYIGIVLIITLFFGVLYWNKASLADRYVYIAGTLLTVLTTTLIPWNKFIQTPLSVIQFPYRLNGLATLLLSIYLSRIVQVWFSNSYSHYRIPTISLLALTLIPVGLVYSGEQQLITARENIPYLSKRPTVRHYYPQQNGTSYNVTMSEWNNQLHYYAHNGSFDYFPKAVGDKVTQIALHKGIINGKAVPLGKQLTSSPNQLRYYLSNIKAGEKVELPILYYQNDLVKVGNQEYRKPMVTNHSLIQITVPQHNKYVTVKYKDSLVDIISVWISVLTWLGIIIYYLGYKIRSMQ
>NZ_CP044534.1|WP_083482718.1|1265942_1267007_-|acyltransferase-family-protein
MSSMWKDQGMKRDSRFELLRIISMFMIIIFHFDYFGQKWRVPSIHSFWDYTLLSSYLSLGKLGVYLFIMITGYFVGNKTFPISKSLLKSCSIWLEAFYYSVGIYIVLSLTKLTTFSFGQLIKCALPFMTDQYWFVDAYLILLLLIPFINICLNQLSRRQFFYLVIVMSFLSSALTPIKSVIFSTEIQFGYILPAYLIGAYIKKYNIRIAFIKSKIIIIYLFTIICAAGCYQTGKTNYINVFFFGIPQLLLATLIFIEVTQERSFVNRYVNSIAKTVFASYLITDNLLVKGLLWNLPVFHNNRISMFQINAFGIVFVLALLMACSLIDYFRILLFSHVNINNIFTKFLSKVRSNL
>NZ_CP044534.1|WP_057752303.1|1267023_1268601_-|peptide-chain-release-factor-3
MSSKQLADAVNKRRTFAIISHPDAGKTTITEQLLLFGGVVREAGTVKARKTGNFAKSDWMEIEKKRGISVTSSVLQFDFQGKRINILDTPGHEDFSEDTYRTLMAVDSAVMVIDSAKGIEPQTKKLFKICKMRGIPIFTFMNKFDRDAREPLDLLNEVEDTLGIETYPMNWPIGSGRQFKGIYDRYNHRVALTHPSDPKHPYLPLDEDGNVKGENPLAGDGEWQDALDGMELVEVAGNQLDRDKIAAGDQTPVFFGSALTNFGVQTFLETYLQFAPAPSSHHTENDGDVHPLDPEFSGFVFKIQANMNPRHRDRIAFVRICSGKFDRGMDVTLERTQKPMRLSNVTEFMADTRENVEKAVAGDIIGLYDTGNFQIGDSIYTGKKDIKFEKLPQFTPELFMRVSAKNVMKQKSFHKGINQLVQEGAVQLFRSYSTGDYILGAVGQLQFEVFKFRMKNEYNSDVIMEPMGNKTARWIDPDQLDEKMSSSRNILVKDIHDQPLFLFENQFAENWFKQKYPDVKLTSKL
>NZ_CP044534.1|WP_057752300.1|1268693_1270190_-|carnitine-transporter
MIKSNLRKIDWSLVLIPILAIVMISYLLEQFPQSAHHILTSIRVFFNDQLTVIYILVGLFFFLSTLYVAFSKIGHKKLGNKDDHPEYSNLRWGVMIFTSTMSADIIFYALCEWMMYAQEPFIQSKGNVMEWSLTYSLFHWGPIAWSFYIMLAVAFAYMLFVTKNQRQKFSEACRPILGKYTDGILGKLIDLIAIFALLAGTATTFSMSMPLLSAVVGHLFHINSLTRLSLVLIIIVVLIYLIASVMGMKAISRLSAICYTFFIGLLLYVLLFSGNANFILDSGLQAVGNLTQNFIGMATTTRNHDFTQNWTIYYWSYWIIWCVATPFFIGSISKGRTIRDVVIRAYAWGLGGTFLAFIILGNFGMSCQIHHLINVSHLIASGNSYAHVALLIMKTLPQYRLALILLALAMIGLYSTVFDSITMVISKYSYRQLSLDEEPSKLLRGFWAIAFMILPTALLVSHSNMNNIQSVAIIAALPTMIVMILIVMSFYKEIRRNS

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Crispr_ID: NZ_CP044534_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044534_2

1304415-1304514

Unclear

Consensus_repeat	Method
AGTCGTAACGCGTTCAGCCTAAT	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_CP044534_2

>merge|NZ_CP044534|2|1304415-1304514|CRISPRCasFinder
AGTCGTAACGCGTTCAGCCTAATGTTCTACTATTACATAGTCGTAACGCGCTCGCCGGCTGTTTTCTAATGCTACTATGTCGTAACGCGTTCAGCCTAAT

>NZ_CP044534|2|1|1304415-1304514|CRISPRCasFinder
AGTCGTAACGCGTTCAGCCTAAT	GTTCTACTATTACATAGTCGTAACGCGCTCGCCGGCTGTTTTCTAATGCTACTA
TGTCGTAACGCGTTCAGCCTAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044534.1\|WP_057752231.1\|1294376_1294619_+\|DUF2922-domain-containing-protein	unknown	unknown	gnl\|CDD\|378571
NZ_CP044534.1\|WP_057752194.1\|1309322_1310867_-\|glutamate--cysteine-ligase	unknown	unknown	gnl\|CDD\|179427
NZ_CP044534.1\|WP_057752222.1\|1297491_1299000_-\|glutamate/gamma-aminobutyrate-family-transporter-YjeM	unknown	unknown	gnl\|CDD\|237929
NZ_CP044534.1\|WP_057752217.1\|1300335_1300785_+\|flavodoxin	unknown	unknown	gnl\|CDD\|180922
NZ_CP044534.1\|WP_057752205.1\|1306075_1307095_-\|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl\|CDD\|223745
NZ_CP044534.1\|WP_057752226.1\|1296051_1297398_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
NZ_CP044534.1\|WP_057752234.1\|1294141_1294354_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044534.1\|WP_057752214.1\|1300784_1301219_+\|GtrA-family-protein	unknown	unknown	gnl\|CDD\|377229
NZ_CP044534.1\|WP_057752220.1\|1299370_1300225_-\|type-I-methionyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
NZ_CP044534.1\|WP_057752191.1\|1311000_1311891_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|181359
NZ_CP044534.1\|WP_057752228.1\|1294682_1295591_-\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|377085
NZ_CP044534.1\|WP_057752196.1\|1308323_1309256_-\|malate-dehydrogenase	unknown	unknown	gnl\|CDD\|133427
NZ_CP044534.1\|WP_057752183.1\|1313267_1313645_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044534.1\|WP_057752211.1\|1301679_1303092_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_CP044534.1\|WP_057752186.1\|1312913_1313246_-\|cysteine-methyltransferase	unknown	unknown	gnl\|CDD\|226219
NZ_CP044534.1\|WP_057752360.1\|1303153_1304281_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|272978
NZ_CP044534.1\|WP_057752199.1\|1307758_1308331_-\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|129813
NZ_CP044534.1\|WP_057752208.1\|1304756_1306064_-\|DEAD/DEAH-box-helicase	cas3	mkCas0139_cas3_CAS-I	gnl\|CDD\|223587
NZ_CP044534.1\|WP_057752189.1\|1311903_1312791_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|181359
NZ_CP044534.1\|WP_057752202.1\|1307250_1307616_+\|DUF4828-domain-containing-protein	unknown	unknown	gnl\|CDD\|374370

Protein	Function_ID	Function_description	E-value
NZ_CP044534.1\|WP_057752231.1\|1294376_1294619_+\|DUF2922-domain-containing-protein	gnl\|CDD\|378571	pfam11148, DUF2922, Protein of unknown function (DUF2922). This bacterial family of proteins has no known function.	5.20202e-15
NZ_CP044534.1\|WP_057752194.1\|1309322_1310867_-\|glutamate--cysteine-ligase	gnl\|CDD\|179427	PRK02471, PRK02471, bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB.	4.03187e-102
NZ_CP044534.1\|WP_057752222.1\|1297491_1299000_-\|glutamate/gamma-aminobutyrate-family-transporter-YjeM	gnl\|CDD\|237929	PRK15238, PRK15238, inner membrane transporter YjeM; Provisional.	0
NZ_CP044534.1\|WP_057752217.1\|1300335_1300785_+\|flavodoxin	gnl\|CDD\|180922	PRK07308, PRK07308, flavodoxin; Validated.	2.3012e-47
NZ_CP044534.1\|WP_057752205.1\|1306075_1307095_-\|Gfo/Idh/MocA-family-oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.36443e-39
NZ_CP044534.1\|WP_057752226.1\|1296051_1297398_-\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	3.69385e-08
NZ_CP044534.1\|WP_057752214.1\|1300784_1301219_+\|GtrA-family-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	1.15579e-14
NZ_CP044534.1\|WP_057752220.1\|1299370_1300225_-\|type-I-methionyl-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.12354e-125
NZ_CP044534.1\|WP_057752191.1\|1311000_1311891_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|181359	PRK08293, PRK08293, 3-hydroxyacyl-CoA dehydrogenase.	3.93008e-164
NZ_CP044534.1\|WP_057752228.1\|1294682_1295591_-\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	4.43602e-52
NZ_CP044534.1\|WP_057752196.1\|1308323_1309256_-\|malate-dehydrogenase	gnl\|CDD\|133427	cd05291, HicDH_like, L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases. L-2-hydroxyisocapronate dehydrogenase (HicDH) catalyzes the conversion of a variety of 2-oxo carboxylic acids with medium-sized aliphatic or aromatic side chains. This subfamily is composed of HicDHs and some bacterial L-lactate dehydrogenases (LDH). LDHs catalyze the last step of glycolysis in which pyruvate is converted to L-lactate. Bacterial LDHs can be non-allosteric or may be activated by an allosteric effector such as fructose-1,6-bisphosphate. Members of this subfamily with known structures such as the HicDH of Lactobacillus confusus, the non-allosteric LDH of Lactobacillus pentosus, and the allosteric LDH of Bacillus stearothermophilus, show that they exist as homotetramers. The HicDH-like subfamily is part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	8.20404e-60
NZ_CP044534.1\|WP_057752211.1\|1301679_1303092_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.23715e-64
NZ_CP044534.1\|WP_057752186.1\|1312913_1313246_-\|cysteine-methyltransferase	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	7.22877e-24
NZ_CP044534.1\|WP_057752360.1\|1303153_1304281_-\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|272978	TIGR00236, UDP-N-acetylglucosamine_2-epimerase, UDP-N-acetylglucosamine 2-epimerase. This cytosolic enzyme converts UDP-N-acetyl-D-glucosamine to UDP-N-acetyl-D-mannosamine. In E. coli, this is the first step in the pathway of enterobacterial common antigen biosynthesis.Members of this orthology group have many gene symbols, often reflecting the overall activity of the pathway and/or operon that includes it. Symbols include epsC (exopolysaccharide C) in Burkholderia solanacerum, cap8P (type 8 capsule P) in Staphylococcus aureus, and nfrC in an older designation based on the effects of deletion on phage N4 adsorption. Epimerase activity was also demonstrated in a bifunctional rat enzyme, for which the N-terminal domain appears to be orthologous. The set of proteins found above the suggested cutoff includes E. coli WecB in one of two deeply branched clusters and the rat UDP-N-acetylglucosamine 2-epimerase domain in the other. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	6.2274e-120
NZ_CP044534.1\|WP_057752199.1\|1307758_1308331_-\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	3.37457e-40
NZ_CP044534.1\|WP_057752208.1\|1304756_1306064_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.18334e-87
NZ_CP044534.1\|WP_057752189.1\|1311903_1312791_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|181359	PRK08293, PRK08293, 3-hydroxyacyl-CoA dehydrogenase.	1.33233e-153
NZ_CP044534.1\|WP_057752202.1\|1307250_1307616_+\|DUF4828-domain-containing-protein	gnl\|CDD\|374370	pfam16110, DUF4828, Domain of unknown function (DUF4828). This family consists of uncharacterized proteins around 120 residues in length and is mainly found in various Enterococcus and Lactobacillus species. The function of this family is unknown.	4.30394e-37

>NZ_CP044534.1|WP_057752360.1|1303153_1304281_-|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MRGPFKIMLLFGTRAEALKLAPIIEQMKKDPTTWQPSIVVAAQERRSLLQQTMKFLNVKSDFDLDTSEISHVNAAEKLSQLLHNFNNVINASQPDMMLVVGDAATSLAASLVSFYHHLPLGHVEAGLRTYDKFSPFPDEMHRRLTDDLADLYFAPTTGARDNLLSEHHPAEQIYVTGNTSIDAVRERLTADFHNEVLDQIPDDHRLIILTMQRPESIGAPMERVFHTMKDVVETNPDVDVIYPVYPNSEVISMADDVLSNQDRVHLIEPLNHSDFLNLVARSDFLITDSGSIQEEAPALHKPVLLLREKTERQEAVEEGSVKIVGTNPTSIQQAVFELLHKPKIYRKMAEAPNPFGDGHASEKILQIIQDYLTHK
>NZ_CP044534.1|WP_057752211.1|1301679_1303092_+|multidrug-efflux-MFS-transporter
MNTKPQARQHVRHPKLAMVSMLLGAFVGMFSETSLNIALPNLIRALHVNTSTIQWLVTGYMLVIGIILPLSSLISKWFTTRQIIIFALADFIVGSVISALGSSFMVVLIGRMIQGIGTGLILPLMFAVVMQIFPPQKIGAVMGVCALVIMFAPAIGPTLTGLILAKLSWNWIFWAFVPFLAIALIFAITSLENVGHLTRPHVDILSILESAVGCSGLVIGASLSSRDGWLSMPVMIALIVGVVVLALYIHRQLHLDAPILNLKVFANKSFAIGSTLVMLDFGIILSAMYLLPMYIQNGLLLPVALTGIIMLPGGIINALTSAFAGRMYDQVGAKKPAMIGFVIALVGAIMLACTTPHSSVAYVIAAHVILMIGCPLAMSPSQTSALNSLSGMQSADGSTILNTMQQIVGALATALATSFLELGRMAGTGNLATKFTNGVHWGIYFTIVLVVIGILLTFLMQDKAHSEDLK
>NZ_CP044534.1|WP_057752214.1|1300784_1301219_+|GtrA-family-protein
MVKHLWNKYKAIIAYLFWGVVTTIVNLVVFQILSPGLHWGVILSTVLAWVAAVLVAYFTNKVWVFGSHYTTVMDTLVEMLRFFFYRGVTLIIDIVITYVGIKMLKFDSPLQQFIVKFIDNVIVVIANYIFSKWLIFRNNRGIER
>NZ_CP044534.1|WP_057752217.1|1300335_1300785_+|flavodoxin
MAKAMVVYATITGNNEDVADVITEALEDQGVEVDETEITMADVADFDDVDICVVCPYTYDEGALPEEGLDFYDDLKEADLSGKVYGVAGSGDTYYADDFCVAVDEFGKAFDKAGATKGAENVHINLAPDEDDIKKLDAFAKQLVDKAGK
>NZ_CP044534.1|WP_057752220.1|1299370_1300225_-|type-I-methionyl-aminopeptidase
MITLKSPREINAMEKAGAALAGMHIGIRQFIRPGISSWEIEKFAREYFKKIGAKAEQIGFEGYKYATCVSVNDEICHGFPRRKLMLKDGDLVKVDTVLSIDGFFADSCWSYGVGEVKPEIQKLMDVTKKSLFMGIDQCIPGNRIGDIGAVIQHYTEDENGYGDVREFVGHGIQPTMHEDPMVPHYGEHGQGLRLKNGMTITVEPMINTGTWKADTSDPSGWLAKTADGGWSCQYEHTLVVTDKGPKILTSQDPEADADYMYDDDYVKYFDHYSKIAKEVAQSYK
>NZ_CP044534.1|WP_057752222.1|1297491_1299000_-|glutamate/gamma-aminobutyrate-family-transporter-YjeM
MDEQSSNKKMITTFGLVTMIITAIFGFGNVSNAYLQMGYGSIIWYALAGICFFFPCGLMMAEYGSAFKDAKGGIYSWLAGSIGERMAFIGTFVWLASWIVWMVSTASRIWITFSALIFGKDTTQQWKFMGLSSTEVIGILGILLMIACTYFSSRGMTAIAKVGSLGGIFTVVVNIIYVIAAIVVLIINKGALAQPFHGASSLVMSPNTQFQTPIAIISFVVYAIFAYGGMESLGSVTDSMKNPEKTFPRGLIIASIFTIGAYVIMILMAGWFANYKHDFAVSTTNLGNATYVLFNILGVKLGTALGFSHAAALEWGAAMTRIVAFSQALGFLGALFVLMYSPIKAFILGSNPELWPKKLTKLNKAGMPANAMWLQVTVVSIIIFLVAFGGSAAQKFYTILTDMANVSTCFPYLFLVGAFPFFKKRTDIDRPFVVFKNKALTNTIVWFVEIILIVGILFTFIQPMLDHDWQTAFWTIAGPIFFAGVAWAFYQASAKKHHIKQN
>NZ_CP044534.1|WP_057752226.1|1296051_1297398_-|MFS-transporter
MSHLLGLDTPGWEPRYKRNVIVYLWVYGILGGVTGITNNALLSYLDIVAPKVVTGLNTFSAISTLLMSLTILLVHSMGYKKILLAAAPVTIIGLLGTIVTKNPMLIVVGYVISQTTIGLYDYMYPIMFSVYVPKKVRTRLFTIVMSDNLIFQTVVTFFGGKLVVWFFSLFQGLTYNQASTWSAHQDAMKSMMLANYANSYKVIIFVAIIMNVIAFLITFGFKEQPSDYKTTAAEAKAKGKKKFNWSSYKKLCTKPVIVFTIYIAICQAGALLITPYLPIYLNNYLHIPRGITSTINTIQTAAMFLGYFCSPFMEKKMGTVVAVAGSTIACIPLMLIMGIGHALGTGMTLIVVVTITYFLRSGIANAAMPVQNTLQMFLVNKDLRPAFTSLTTLVIAGVGILDGFFTEFYLLKTMQGYATAYFVASGLYLVGSLILIIYLKKDYNRIDK
>NZ_CP044534.1|WP_057752228.1|1294682_1295591_-|YihY/virulence-factor-BrkB-family-protein
MRAENKLKLKTFFAMLVKHFTLAQLSSSAATLAYYTLLSVFPALLVVGNLLPMIGLDANTILGYLQTIVPATVYSFTKPLVQDFLQRGSGGILTTGALIALWSTSQGIAAFQRSVNHAYGIAENQNPISNRVISFIWMIVVLIAIFLVVFLYGVGEQFLKWLQPIFHFNMKYITLFSSLKWPITFLILFLALTMLYYFVPNAKVGLRFAVIGAFLASIFWMWLSRIFALYTVIFSRGVIGYKTIGAFIAMMVWLDFSGYIIMMGAALNAALQEAHDGELHEKEHFWKLIRTEHKKARKSIVK
>NZ_CP044534.1|WP_057752231.1|1294376_1294619_+|DUF2922-domain-containing-protein
MKTLNLTFKGSLGKKHLLKLAYAKQDLSEAVVRQAMQEIAQTHMFNSKDEDIYAEPLSAKYVDTVSTVIFNDSKKDKAAA
>NZ_CP044534.1|WP_057752234.1|1294141_1294354_+|hypothetical-protein
MNMVRQFKSGKIQLTMVSEAHPKGIKRTFNNVIADVEEEQITTLGHAIEALSGEQFSGANIINNDQVTFA
>NZ_CP044534.1|WP_057752208.1|1304756_1306064_-|DEAD/DEAH-box-helicase
MIEQFQQKFEQEFKQPTEIQRAVADALTNDKSVLGIAPTGSGKTLAFTLPLLPKISPGDGTQLLVLAPSQELAMQTTHVMREWANLIGVKVQSLTGGANLRRQVMKLHSHPDVVVGTPGRVLHMLDNRHLKLGHLQTMMIDEADDLLRDDTLAVVEDIERATPLSAQLAFFSATMSPVFKELSVMFGRDIVTYDVRDQDHSRGPVRHGFMYARTNAQKTATLRRFTSIKDFRGLVFFNSTRTLHYAASRLRHEHMPVGTLGGRQKQTQREKALRMFRKRQLKLLLTTDVAARGIDIPKLPAVINFDLPKEVNTYIHRSGRTGRQGEPGLVVNLGDDHDIRDLKHLLTDTDYKFEHLYVDHDQITDQKPEKGQRVVSVRKKNARKLQKEQWSAEGTVEKSIHRTLGKLKPKKKKRHKKNRKNKGIRLKHRREHAQK
>NZ_CP044534.1|WP_057752205.1|1306075_1307095_-|Gfo/Idh/MocA-family-oxidoreductase
MLKLGIIGTHIITDQMLDAAKTTGKYQLTAVYSRTMDRAKEFGQPYGATEFYDDIQRFFENGDFDVVYIASPNSCHYQQARLAIENDKFVIVEKPSFVNPEEFSAIESLLAAHPKARLVEAARHIHTPLYEAALDKVNEMKKSHIQGATITVMKYSSRYDKVLADDKPYPNIFTLDFAGGALMDLGVYAVYGAVTMFGEPASVVYFPTLAKTGVDAKGVAILNYDKFSVTLNFGKTANSHLPSEVYGLKDTLVYDSIFNTKKVTYYDADQNAHPFDQPVEKNSMTDEMNDFADLFNNPDDKDEQAKYQRWLDLAHTVNSVMYSLRQSAQLKFPADQKQE
>NZ_CP044534.1|WP_057752202.1|1307250_1307616_+|DUF4828-domain-containing-protein
MRKKGLLLFGAGLMAGLSSSLGFSHGHKNVKGKTSLPIFYAGTWRYYDKERDRSHIITISPELKLGIDNHEMPATVQQVREDKLVYLDKFGYHITIQANEQRPVSLIDEADDQVYSIQPMQ
>NZ_CP044534.1|WP_057752199.1|1307758_1308331_-|TIGR00730-family-Rossman-fold-protein
MIKRMAVFCGARKGNQEKYIKQADALGKYMADHDIELVYGGGQFGLMGALADAVLDNGGEVHGVITESLAERGVANPRVKDMRTVAGMNLRKEKMMEKADGMLALPGGVGTLEEISQCTSWMTIGENPKPVAFYNLDGFYDHLRELFVEMNKDGFLEQRFLDAICFSENFDEILSFMNNYKTPEYRKYRN
>NZ_CP044534.1|WP_057752196.1|1308323_1309256_-|malate-dehydrogenase
MRSIGIIGLGHVGRQLATQLVTGRQVDRLTLIDQDDDLALAIQTDLTDLAGIQNTYPEIIIQDWAALANSEIVVTAFGKSKLQTQTTDAELTFNQQAACQVADQLKSQQFAGILINVADPNEAVTAYLQEKAALPPKHVLGVGTSLETIHMRRAVAHAVQLSPANVSGFVYGQHNGQQVFAWSTVKVNGQSLDQSLNGHHVDLNQAKVRADMNNWYTLHGMHYNAAGIAGVVVQIIQAILENQNLALPLAIYQPQYNTYVSFPTLINRQGQGNLLLLKLYPVEENAVKVAATAVQSQLASLRKLEGEHDD
>NZ_CP044534.1|WP_057752194.1|1309322_1310867_-|glutamate--cysteine-ligase
MTDRYSAIREAFHEPEINAQLFNSQFGLEAKKHRVLTNGRASRYPYPAALRSRKHNLYLNSGFTDNMIDFETEPVVGSKAAVRQLKMLEQIMISQLHEDERLWPLSLAPAPVYQHDLDYLITDNSKTWDQANHDYLGKKYGITQEIMGDVHVNYSLDPQLVQTLYRRFYTDQYDNLVDFQNHLYFKLAQSFVLYQWLFTYLYGASPVSEDMKLPEKLDLPVRSLRSSDYGDDNLPDEQIGYDSLESHFAQLQQYLDDGTYYSLKEFFGPVRCRRHNQDNKDLQGMLDHGINYLEFRSFDLDPLSRTGVSDDTINFLELLMLDSIISPLPDNLSERLQAARKLNNEVALQQPKEQTPEMRAAADKLIDKLQKLVDEFNAPKEYRMALKFVQRRVDDPSLTISGQLADQIENGNLLSFGLKLANDRFTANMNLTHPLQAVSETYSDSVQQILRAAIELGVNVKLADTNVTLSVADHQESYGAAGEFTFPDGPRAFVLNAFPEAKAFQEDSDEADAE
>NZ_CP044534.1|WP_057752191.1|1311000_1311891_-|3-hydroxyacyl-CoA-dehydrogenase
MTFKNITVAGAGVLGSQIAYQIALKGFKVTVYNHHIDTAEKRLHALKADYQHDLHLTDEEFQAGLDNIVNITTDLKAAVADADYVIEALPESLDLKEKFYTELSEVAPAKTVFASNSSSFIPGQLVKYVDRPNKYLHMHFANKIWRFNVAEIMGTNQTDPAVYQEVVDFARAIGMVPIELHKEQHGYVLNAVLIPLLGSAMQLWANGVSDPQTIDKDWMISTSSPMGPFMIIDMVGLRTPYQMEINTYQTTKDPIHQTIADKLKSMIDAGHTGQESGQGFYHYPNPEFEDPEFLKK
>NZ_CP044534.1|WP_057752189.1|1311903_1312791_-|3-hydroxyacyl-CoA-dehydrogenase
MAFKNVMIAGTGVLGSQIAYQTALNGFHVIAYNDNVDSAKKRLAALQPAYEADLGLSKADFDQTLAQIVVTDDLKTAVQDVDYVIEALPENIKIKEEFYKQLSQLALAKTIFASNSSTMVPSQLVKFVDRPQKFLHMHFANRIWKCNVAEIMGTDQTDPAVFEEVIDFAHQIKMVPIPIHKEQPGYVLNSLLIPFLVSAMLLWVKGVADPETVDKDWMISTGAPVGPFMMLDDVGLRTTYQIMMGLYQTRGNDYFKTIADKLKVMIDAGKNGRESGQGFYSYPHPAFEDPDFLKK
>NZ_CP044534.1|WP_057752186.1|1312913_1313246_-|cysteine-methyltransferase
MVKLDEQMMHDILEVVDQIPAGCVATYGQIARLIGRPRNARLVGKALGHSGRYGKHPCHRVVTVNGRLVPGWIDQGPMLKAEHIPFKDDAHVAINRCQWQKGNKTLISRR
>NZ_CP044534.1|WP_057752183.1|1313267_1313645_-|hypothetical-protein
MMDENKFRQQAPWAIPSNAQFSEDHRVGYRQISFHWEDAGWQYNARWHQQLPTATLITYPSWQLSRVLPGKGFGPAAHQRREEVLVGDQWLPMRQIRYCALRLAKGVATSQELMLLKRAHVRASF

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Crispr_ID: NZ_CP044534_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP044534_3

1537255-1537359

Orphan

Consensus_repeat	Method
TCTCATGCTGCCAAGTCGAAACGTGCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP044534_3

>merge|NZ_CP044534|3|1537255-1537359|CRISPRCasFinder
TCTCATGCTGCCAAGTCGAAACGTGCTCACCAGGAGGTCTAAGACAACATAGTTGAAACGTGCTCACCCTAAGCCCTTCTCATGCTACCAAGTCGAAACGTGCTC

>NZ_CP044534|3|2|1537255-1537359|CRISPRCasFinder
TCTCATGCTGCCAAGTCGAAACGTGCTC	ACCAGGAGGTCTAAGACAACATAGTTGAAACGTGCTCACCCTAAGCCCT
TCTCATGCTACCAAGTCGAAACGTGCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP044534.1\|WP_057748949.1\|1533406_1534168_-\|acetoin-reductase	unknown	unknown	gnl\|CDD\|181518
NZ_CP044534.1\|WP_057748959.1\|1530401_1530824_-\|NUDIX-domain-containing-protein	unknown	unknown	gnl\|CDD\|239520
NZ_CP044534.1\|WP_057748968.1\|1528851_1529289_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237171
NZ_CP044534.1\|WP_057748924.1\|1544987_1545752_-\|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl\|CDD\|372574
NZ_CP044534.1\|WP_057748913.1\|1546832_1547483_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|372595
NZ_CP044534.1\|WP_151495803.1\|1537460_1538534_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270381
NZ_CP044534.1\|WP_057748935.1\|1540154_1541246_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
NZ_CP044534.1\|WP_057748956.1\|1530965_1532360_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NZ_CP044534.1\|WP_057748929.1\|1543939_1544851_+\|proline-specific-peptidase-family-protein	unknown	unknown	gnl\|CDD\|188121
NZ_CP044534.1\|WP_057748971.1\|1527984_1528833_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP044534.1\|WP_057748917.1\|1546359_1546689_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NZ_CP044534.1\|WP_057748932.1\|1541386_1543774_+\|Xaa-Pro-dipeptidyl-peptidase	unknown	unknown	gnl\|CDD\|235435
NZ_CP044534.1\|WP_057748964.1\|1529359_1529800_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
NZ_CP044534.1\|WP_057748941.1\|1538530_1539349_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
NZ_CP044534.1\|WP_057748953.1\|1532459_1533197_-\|glucose-1-dehydrogenase	unknown	unknown	gnl\|CDD\|187600
NZ_CP044534.1\|WP_057748920.1\|1545748_1546363_-\|DUF1700-domain-containing-protein	unknown	unknown	gnl\|CDD\|227053
NZ_CP044534.1\|WP_057748938.1\|1539348_1540155_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224097
NZ_CP044534.1\|WP_057748974.1\|1526934_1527501_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP044534.1\|WP_057748947.1\|1534458_1537125_+\|HAD-IC-family-P-type-ATPase	unknown	unknown	gnl\|CDD\|319775
NZ_CP044534.1\|WP_057748962.1\|1529844_1530402_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|234719

Protein	Function_ID	Function_description	E-value
NZ_CP044534.1\|WP_057748949.1\|1533406_1534168_-\|acetoin-reductase	gnl\|CDD\|181518	PRK08643, PRK08643, (S)-acetoin forming diacetyl reductase.	1.72881e-119
NZ_CP044534.1\|WP_057748959.1\|1530401_1530824_-\|NUDIX-domain-containing-protein	gnl\|CDD\|239520	cd03428, Ap4A_hydrolase_human_like, Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant enzymes fall into one subfamily and fungi/animals/archaea enzymes, represented by this subfamily, fall into another. Bacterial enzymes are found in both subfamilies. Ap4A is a potential by-product of aminoacyl tRNA synthesis, and accumulation of Ap4A has been implicated in a range of biological events, such as DNA replication, cellular differentiation, heat shock, metabolic stress, and apoptosis. Ap4A hydrolase cleaves Ap4A asymmetrically into ATP and AMP. It is important in the invasive properties of bacteria and thus presents a potential target for inhibition of such invasive bacteria. Besides the signature nudix motif (G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val) that functions as a metal binding and catalytic site, and a required divalent cation, Ap4A hydrolase is structurally similar to the other members of the nudix superfamily with some degree of variation. Several regions in the sequences are poorly defined and substrate and metal binding sites are only predicted based on kinetic studies.	3.81058e-37
NZ_CP044534.1\|WP_057748968.1\|1528851_1529289_-\|hypothetical-protein	gnl\|CDD\|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.000544803
NZ_CP044534.1\|WP_057748924.1\|1544987_1545752_-\|DUF4097-family-beta-strand-repeat-protein	gnl\|CDD\|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	4.20242e-10
NZ_CP044534.1\|WP_151495803.1\|1537460_1538534_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270381	cd13663, PBP2_PotD_PotF_like_2, The periplasmic substrate-binding component of an uncharacterized active transport system closely related to spermidine and putrescine transporters; contains the type 2 periplasmic binding fold. This group represents the periplasmic substrate-binding domain that serves as a primary polyamine receptor of an uncharacterized ABC-type transport system from gram-negative bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, as well as plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.60558e-141
NZ_CP044534.1\|WP_057748935.1\|1540154_1541246_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	9.66224e-162
NZ_CP044534.1\|WP_057748956.1\|1530965_1532360_+\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.43436e-114
NZ_CP044534.1\|WP_057748929.1\|1543939_1544851_+\|proline-specific-peptidase-family-protein	gnl\|CDD\|188121	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily. This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase.	1.35624e-147
NZ_CP044534.1\|WP_057748938.1\|1539348_1540155_-\|ABC-transporter-permease	gnl\|CDD\|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	3.26954e-79
NZ_CP044534.1\|WP_057748917.1\|1546359_1546689_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	1.00173e-18
NZ_CP044534.1\|WP_057748932.1\|1541386_1543774_+\|Xaa-Pro-dipeptidyl-peptidase	gnl\|CDD\|235435	PRK05371, PRK05371, x-prolyl-dipeptidyl aminopeptidase; Provisional.	0
NZ_CP044534.1\|WP_057748964.1\|1529359_1529800_-\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	9.92657e-32
NZ_CP044534.1\|WP_057748941.1\|1538530_1539349_-\|ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	9.75215e-82
NZ_CP044534.1\|WP_057748953.1\|1532459_1533197_-\|glucose-1-dehydrogenase	gnl\|CDD\|187600	cd05341, 3beta-17beta-HSD_like_SDR_c, 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs. This subgroup includes members identified as 3beta17beta hydroxysteroid dehydrogenase, 20beta hydroxysteroid dehydrogenase, and R-alcohol dehydrogenase. These proteins exhibit the canonical active site tetrad and glycine rich NAD(P)-binding motif of the classical SDRs. 17beta-dehydrogenases are a group of isozymes that catalyze activation and inactivation of estrogen and androgens, and include members of the SDR family. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	8.30682e-110
NZ_CP044534.1\|WP_057748920.1\|1545748_1546363_-\|DUF1700-domain-containing-protein	gnl\|CDD\|227053	COG4709, COG4709, Predicted membrane protein [Function unknown].	6.25388e-10
NZ_CP044534.1\|WP_057748913.1\|1546832_1547483_+\|HAD-family-hydrolase	gnl\|CDD\|372595	pfam13419, HAD_2, Haloacid dehalogenase-like hydrolase.	8.52114e-43
NZ_CP044534.1\|WP_057748974.1\|1526934_1527501_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	2.45591e-09
NZ_CP044534.1\|WP_057748947.1\|1534458_1537125_+\|HAD-IC-family-P-type-ATPase	gnl\|CDD\|319775	cd02080, P-type_ATPase_cation, P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase. This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
NZ_CP044534.1\|WP_057748962.1\|1529844_1530402_-\|AAA-family-ATPase	gnl\|CDD\|234719	PRK00300, gmk, guanylate kinase; Provisional.	1.44942e-34

>NZ_CP044534.1|WP_057748947.1|1534458_1537125_+|HAD-IC-family-P-type-ATPase
MKKQYQLTLNEIKQQNKLASFTDGLSTSEAQARLSKNGPNVLEAKTTPKWKMFLRQFNNIVIYILLVATMLTIIIGHYTDAIVIGAVVILNSLIGYFQESSAANALAKIKEMMAQNATVYRDQERQDIEAADLVVGDIVFLEAGDNVPADLRIVSADNLRIEESALTGETNSVAKTADALSDNDIPLAERTNMAYASTSVTSGSGMGIVVATAEDTEIGKISQEVSHIKPKKTLLTREIGNVGKVVSYITITASVIVFIVGFMLQIYSLPALALAVVAMLVGAIPEGLPAITSVILAFGISKMAKQHQTIIKSMPAVETLGSVDVIATDKTGTLTKNEMSAVELWVGNTHYDVSGTGYAPQGKIMLNGQPAKLTKQLKLFLEAGFQANDTVLAKNDGKWQINGEPTDGAFLTLYHKALGVDHQSNYQKIDLLPFDSDYRYIAELTKDRQTGQQFVFVKGSPDKLFEMAALADPFFDQAEWQNRVNEWSQAGKRVIAVGYQPVQGTALTEVHHDQLYKGVHLLGLAALLDAPREEVITALKQMNRAGVHVKMITGDDPQTARAIGQQLGLTNGPIHAITGAQWDQLSPEEQQETALQTQVFARTTPQNKLEIIDALQKKQQVTAMVGDGVNDAPALKKADIGVAMGIKGTDVAKDAADMILGNDNFATMAAVIKEGRRIYDNIKKSILFLLPTSFAEGLVVAFSILTGQQVPLQPAQLLWINLIAAITIQFAFVFEKAEEGIMEREPRPMTQRLMNRHDLIQMGYVAALMAIFALIGYYWFIGQGADAINATTMMVNVIVISKIFYFFSIRTDQPALGQIKTISGKAWGMIGLMILFQLILTYVPFMQTAFKVTAISPMEWLIVVIFSCLIMFVSEGDKIIRLRKVETE
>NZ_CP044534.1|WP_057748949.1|1533406_1534168_-|acetoin-reductase
MAKVAMVTGAGQGIGEAIAKRLANAGYAVAVADLNTDNAQQVANEIKQAGGDALAVTVNVADRDQMFSAVQQTADHFGGFDVLVNNAGLGPVTRIKDVTPEMFDKVMHVNVAGDMWGIQAALEQFEKKPRQGKKVVGKIINATSQAGVRGNKNELLYSSTKFAVRGITQVAARDLAKQGITVNAYAPGIVDTPMMRKIAEDQGLKMSDYESLIALNKLSDPDDVAKVVEFLASDKADYITGQTILCDGGMQFE
>NZ_CP044534.1|WP_057748953.1|1532459_1533197_-|glucose-1-dehydrogenase
MGQLDGKVAIVTGAAKGFGLATTKAFVNEGAKVVMTDVDDKEGQKQAAEIGDKVIFIKQDVSKEEEWPQVFEKAEHTFGPVDVLLNNAGILIFDNAETFKLDDFHKILSVDLDGVVLGQKYGIQHMKKHGGSIINLCSIAGLIGIPNLFSYNAGKGAVRLITKSAALYCCEKKYPIRINSVHPGYAHTPMVDAYPEMRQSLEALHPMGRLGSADEIANMCVFLASDKSSFSTGSEFVTDGGYTAQ
>NZ_CP044534.1|WP_057748956.1|1530965_1532360_+|amino-acid-permease
MGLNILRKESLDRYLGEDKLFVKSMNARDLMAIGIGTVIGTGIFILPGTIAAQQAGPGVTLSFLLSALVCALAAMCYAEFASALPVAGSAYSYGNVVFGEFFGWLLGWALILEYMLAVASVSTGWAAYFNSFIESFGIKIPKALSGPFDPAHGTYINIVAVIIVLLITILLSRGLKTSVRVNNIAVIIKVAIILVFIIAGLFFIKPKNYHPFLPYHMSGVIHGATTGFFAYLGFDCVSSSAAEVKNPKKNMPLGIIGTLGVVAVLYMGVAIVLTGMVPYKKLDVANPVSYALMLVHQDWLAGLLSIGALIGMFTMMVAMIYSSSRLIYAIGRDGLLPAFLGKLDKKSHSPEISLWIVAIIIAVMGGLVSLDQLTSLVNIGTLFAFTLVSFGIIPLRKRSDIGNRGGFKVPLYPVLPILSGLICLAMMTQLKMETYIGAGIWFAIGLIIYFTYGYRHSKLNKNAD
>NZ_CP044534.1|WP_057748959.1|1530401_1530824_-|NUDIX-domain-containing-protein
MAIEVTAGAVVYRRNDTGDIEYLLLQSQNKGHFWGFPKGHVEGSETLLETAQREIKEETQLVLPIDTSFHVYTEYDLPNGNRKQMTLYTAELNQSEDIQLQVEEIKNCGWFTYADARERLTYDNLKELLDQVNTYLVNKA
>NZ_CP044534.1|WP_057748962.1|1529844_1530402_-|AAA-family-ATPase
MVNKVYVIAGAAGSGKTTVANYLQRQYQMQRVITHTTRPPRSSEQEGVDYHFESEQSMERLHLLEEVEYDHHHYGSSMESLEAGWSTGHDNVIVLDTKGALTYHQKLPHQAIIIFLTVSRLTVLAKRMQLRGDQPSAIDSRLHSREYHRDLNLPNYLKGIAHVIVNDDWTTTKRQIDQLIAQLGK
>NZ_CP044534.1|WP_057748964.1|1529359_1529800_-|transcriptional-repressor
MNELIERAHSLMKKHHLRSTKQRQLIIERLVQDPDRYINIMEVDRFLRQTYPGVSHDTIYRNMKEFADCGIVELCANGDQMQVKYRCDVNHHHHFICDVCGKVQEIQMPPLDQQFFAQQLPGAKITGHTFELHGVCANCQKKQGSK
>NZ_CP044534.1|WP_057748968.1|1528851_1529289_-|hypothetical-protein
MAKKIPPIVTPFALFSIALALGATNVVINKATHTSEGAKVTRTSSSFNDRDQQNERNSSSRASSQDDDNNPQQSSSHATNNNNQQNTDDNNNDDNETRQSSTQNHSNNNQQTGNQTNNTAGTNNAGTNTANTNSTNTANTNSTND
>NZ_CP044534.1|WP_057748971.1|1527984_1528833_-|hypothetical-protein
MFSFLDMINSSLSYFNLDVKLKNRIYIVLGFLGDCYLVYVTFRLFANHVWLRAFLYCLAMVALTYFLYLNFVFYFLGKTSEFDFLSPKIAKVTGQKFAENGTPSRGRREDSRFSTGLANQSNGLFAGEDTIPAQVAIDSREQANLQEVVDRLLMEQIFVNDFNGMSERDIIAQYKETERPVQALNTESIPPYFELVHDPMKHRLEIYMGMNQMERKPVGHITKIGLTDVREAHQKYRIYLANLVVTGGPNKIPGRSGTTIMTTADYGLRAQVAYRERNSSNL
>NZ_CP044534.1|WP_057748974.1|1526934_1527501_-|TetR/AcrR-family-transcriptional-regulator
MRVTRTTRDFQNALLTLLEDHSFERLTVDQICREAMLHRSSFYRYFRDKYDLLEQTLNSQVSRVINNSDSEEDIINQLINYIAQHKNVFRHLASETAHSSLYSEMMHIISKILLERRHEKSNDTVIKLLQSADDPEMLAYILSGGIIGTFYWWQEQNYDVSIDQVVKFAEEALISLSNGQRMMRKKHA
>NZ_CP044534.1|WP_151495803.1|1537460_1538534_-|ABC-transporter-substrate-binding-protein
MKKLLSAFVGILVLCLLLAIGDYTMNRQTSGGGSHTLTVYNWGDYIDPALIKKFEHQSGYHVDYETFDSNESMLTKIRQGGTNYDVVVPSEYTVQRMKKEHLLAPLDHRKLPNLKYIDPQFLHRDFDPSNHYSVPYFWGTLGIVYNDQKIAGDQVAHWEQLWNPQLRNNIMLIDSARDVFAVALITQGKSVNTTSYQQLKQAQDHLKQLTPNVKAIVADEMKMYMEQGEAAVGITYSGDAREMMSVNHHLHYIVPTEGSNIWFDNLVIPRTAKNKQGAYQFINFMLKPENAAQNARYVGYATPNWKAKQELPKKVTDDQAFYPPHQTMRHLQTYHDLSLKTLGVYNDLFLEFKMFVK
>NZ_CP044534.1|WP_057748941.1|1538530_1539349_-|ABC-transporter-permease
MKKHSLKWSTIYLAFVFIILYAPIIYLVIYSFSAGKTMESFHGFSFQHYMDLFADTRMITIVINTLLVALLASLLATIIGTLGALAIKDSHGKWRNSLMSLNNVLMVSPDVIIGASFLIFFTVLGVRLGFISVLLSHIAFSIPIVVLMVLPKLNELSPTLVDAAYDLGASRWQTLTRVILPAIGPGIMAGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYSRARQGVNLEINALSTLMFIVSLLLVISYYFISQHAGRRHHLVTVKEGDAQ
>NZ_CP044534.1|WP_057748938.1|1539348_1540155_-|ABC-transporter-permease
MRQKAVFIVPYALWIVLFVIAPLVLILYQSFFNIDGQFTVNNYLTYLTSSVYLKMTVASVWYAFLITAVTLVISYPTAYVLIHLRNKQFWLLLVILPTWINLLLKTYAFIGLFSRNGSINQFLQFVELGSHQLLFTDASFMFVAAYIEIPFMVLPIFNALAEINPSLINASKDLGATQWQTFRSVIWPLSLPGVKAGIQAVFIPSLSLFMITRLIGGNRVITLGTAIEEHFLTTQNWGMGSTIGVILIIAMFIVMFITGDTRQKGGRQ
>NZ_CP044534.1|WP_057748935.1|1540154_1541246_-|ABC-transporter-ATP-binding-protein
MGKNILEFRHVGKKYGDNVVLKDISFDIEAGKFYTLLGPSGSGKTTILRIIAGFDDATSGDVYFDGQRINDVPANKRQVNTVFQDYALFPHMNVAENVAFGLQIKGVDKKTIQERVHQALHMVRLDGYEEREITAMSGGQRQRVAIARAIVNRPKVLLLDEALSALDHKLRVDMQTELRQLQRQLGITFIFVTHDQEEALAMSDQIMIINDGKIQQTGTPVDIYDEPLNHFVADFIGESNIVPAVMKEDYLVNINGQDFECVDAGMKTNERVEVVLRPEDLDITTPDKGKLVATVDTQLFRGVDYQITAHDLRNHEWKINSIHKTTVGQQVGLTFDPEDIHVMRYNESEADFDARLDSYEEEE
>NZ_CP044534.1|WP_057748932.1|1541386_1543774_+|Xaa-Pro-dipeptidyl-peptidase
MHIHQFSICQTSTEQQIKELQQLHLLRGNEANQLDPNQMWLTFLTRVNTASQEPIAIRQWLHDLLATADQAVDDWLADDEPLTTDIFYRVAFQLLQYEPAVDFHLDQPFMDWTRIGLPYRQYTTWTTADVIDAFYLLLNTRNKNGQIYLDQLTSEGFLAWTYKLPADQKPLFFNGKPVACFDPAQFIREVVYIETDLDTDFDGHADLVKAEIMRPVDTEHGLKVPAVFTASPYNQGTNDEWGDISTHHVNHPLIHKDPNYHAPTEMTFPAKSKHQLVAGHSKEATESFATTPAYTLNNYLAVRGYAIVYAAGIGTKDSDGLQTCGSPEQTDSMKAVVEWLHGDRRAFTDRHSGIEIDAWWCNGNVAMTGRSYLGTLSTAVATTGVAGLKAIISEAAISSWYDYYRENGLVRAAGGFQGEDADTLADETFSRTKRPADYKRIEATYQKYAQQMAKAMDRATGNYNAFWDARNYRKYIKGIKCAVMMVHGLNDTNVKPSNVKALYDGLQQLPVTSKLILHQGQHIYINAFQSLDFSEMVNLWLANKLWGLDNDADRRLPNVLVQDNVSAEKWTAYDHWTGASRRWYLSGNQLTNNPVANQDTQSFDDEQPVDKYKAWCQSPAKWQRALMKDNGQFSRHFTSAPVSHELLLRGTPTLTIKVASSLDHGLLSAELVDLGAAQRLTTSPVLINRGGLQLGFHWATDDLREFKQQKKTTAAKVISSGHINLQNRHSAGQVDELAANQMVTVSFDLQPIFHRLVKGHRLGLIIYGTDYEFTLRGNEAVKYTLDVNDAQLTIQ
>NZ_CP044534.1|WP_057748929.1|1543939_1544851_+|proline-specific-peptidase-family-protein
MKTGTKILTLDNGYHLWTNTQGEGDIHLLALHGGPGGNHEYWEDAADQLKKQGLNVQVTMYDQLGSLYSDQPDYSDPAIANKYLTYEYFLDEVEEVRQKLGLDHMYLIGQSWGGLLVQEYAVKYGQHLKGAIISSMVDDIDEYVAHVNALREKTLSPQAVAFMKDCEQRNDYSNPKYQQYVEVMNKEYVDRKQPSKLEHLKDLGGDAVYHVFQGDNEFVITGKLKSWHFRDQLHNIKVPTLLTFGEHETMPLDTAKKMDQLIPNSKLVTTPNGGHHHMVDNPDVYYKHLADFIRQVEAGTFNK
>NZ_CP044534.1|WP_057748924.1|1544987_1545752_-|DUF4097-family-beta-strand-repeat-protein
MKRLFQVGLAILIVGLIALGVGGFNHGNKAVSFEGTKPVIVNKTWTRSKVVNKEFHQINADLSSADVTIVRGNKFQIIYHGKNVPKIQVKNGQATIKQDATDRQVGFHWSSSHYGNDTVTIVVPKGVKLSGRLSLSQGDLYLNNVELDQLTSSIDEGDVAVNNVNANSSQFKLSEGDFRAHRLTVHHHCKVVNDEGDNTVRGVSAEGYYLRTDEGDNSLFHQEQDGEDQTVLQKNSHATNVLTLISSEGDNSIH
>NZ_CP044534.1|WP_057748920.1|1545748_1546363_-|DUF1700-domain-containing-protein
MNAREKYIAELATYLGPLTKVEREDALEFYDEYIADAQLTTVAKIEEKLGTAKQLSHKILADYSIKTNEQSAANGHPASPHSNWRVFWWVVLAIISSPLLFGVGIAALVLLITVAAVAFSIVVGLLGCFIGLAAAAGTTLYTGISLLSFQPFVGLFYGGIGLSLIGLFLICLPLLYWITRWLSQQVANLAKFLYRKLQERRNKQ
>NZ_CP044534.1|WP_057748917.1|1546359_1546689_-|PadR-family-transcriptional-regulator
MKIQITADLLDGMVLALLEQNDHYGYELTQQIQQVVDISESTMYPVLRRLKKDGFLTTYDQPYQGRNRRYYQITATGRKDLANIRTLWRNYKLKLDSLLNEQSEGENSK
>NZ_CP044534.1|WP_057748913.1|1546832_1547483_+|HAD-family-hydrolase
MERQITNFIFDIDGTLIDTYNMYMPAMIEVMEKHGYHVPANQVEPMKKKLFGITGADSLRQAGIRSEDIPEMVAEWGKLAFSREDQVKVFDGVVSTLKELAARPDTHIAIATSKNQDAYDHHFANVWDWSKWFDAVVTEDQTNKHKPDPDPILLAMKKLGASPESSVYVGDTINDLKAAHNAGIKCAGALYGSSQPQNIADADFPLHEPSDLLKID

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

117492 : 125176

Prochlorococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_057750163.1\|117492_118956_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	2.5e-58	34.5
WP_057750166.1\|118952_119990_+	phosphoribosylformylglycinamidine cyclo-ligase	M4QRQ6	Synechococcus_phage	2.5e-60	40.1
WP_057750169.1\|119999_120584_+	phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	8.2e-29	35.9
WP_057750174.1\|120587_122126_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	9.9e-74	46.1
WP_057750182.1\|122313_123573_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
WP_057750185.1\|123732_124419_+	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	A0A1X9IGJ2	Lactococcus_phage	6.7e-06	33.3
WP_057750187.1\|124519_125176_-	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	2.6e-39	42.8

DBSCAN-SWA_2

388028 : 396568

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_057748439.1\|388028_390200_-	class 1b ribonucleoside-diphosphate reductase subunit alpha	A8E2R1	Enterococcus_phage	9.9e-253	60.3
WP_057748442.1\|390312_390534_-	glutaredoxin-like protein NrdH	A0A0M7REK7	Lactobacillus_phage	1.9e-10	44.0
WP_057748445.1\|390781_391297_+	nucleoside deaminase	A0A2H4PQS8	Staphylococcus_phage	1.3e-06	33.1
WP_057748448.1\|391540_393349_+	DNA polymerase III subunit gamma/tau	A0A1U9WR94	Streptococcus_virus	3.4e-57	39.4
WP_057748451.1\|393370_393679_+	YbaB/EbfC family nucleoid-associated protein	NA	NA	NA	NA
WP_057748455.1\|393681_394281_+	recombination protein RecR	NA	NA	NA	NA
WP_057748457.1\|394283_394538_+	YaaL family protein	NA	NA	NA	NA
WP_057748462.1\|394558_395203_+	dTMP kinase	M1PSC7	Streptococcus_phage	1.4e-53	54.1
WP_057748465.1\|395223_395547_+	hypothetical protein	NA	NA	NA	NA
WP_057748469.1\|395560_396568_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	4.0e-31	30.6

DBSCAN-SWA_3

921599 : 929369

Sphingomonas_phage(28.57%)

integrase,transposase

attL 924649:924687|attR 936989:937027

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_057750873.1\|921599_922403_+	N-acetylmuramoyl-L-alanine amidase	Q9MCC8	Lactobacillus_phage	2.3e-53	56.6
WP_083482694.1\|922453_923473_-	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_057750880.1\|923488_924226_-	glucose 1-dehydrogenase	W8CYX9	Bacillus_phage	2.8e-05	37.2
924649:924687	attL	NA	NA	NA	NA
WP_057750884.1\|924756_925605_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	4.5e-36	39.2
WP_057750888.1\|925668_926712_-	dTDP-glucose 4,6-dehydratase	H9NC62	Sphingomonas_phage	1.5e-49	34.8
WP_057750891.1\|926726_927308_-	dTDP-4-dehydrorhamnose 3,5-epimerase	H9NC63	Sphingomonas_phage	1.9e-17	43.1
WP_057750894.1\|927322_928192_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.0e-103	60.8
WP_083482695.1\|928739_928844_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_083482696.1\|928859_929369_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A2I6AZV9	Macacine_betaherpesvirus	7.7e-23	39.9
936989:937027	attR	NA	NA	NA	NA

DBSCAN-SWA_4

1064655 : 1102002

Lactobacillus_phage(47.62%)

integrase,terminase,head,protease,portal,tail

attL 1067342:1067356|attR 1103154:1103168

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_057751250.1\|1064655_1066980_-	hypothetical protein	A6M964	Geobacillus_virus	2.1e-06	43.0
WP_057751253.1\|1066995_1067343_-	hypothetical protein	NA	NA	NA	NA
1067342:1067356	attL	NA	NA	NA	NA
WP_057751256.1\|1067346_1067640_-	hypothetical protein	E9LUJ5	Lactobacillus_phage	3.1e-08	50.0
WP_057751259.1\|1067650_1069798_-	hypothetical protein	D2KRB9	Lactobacillus_phage	4.8e-34	55.9
WP_057751262.1\|1069794_1070763_-\|tail	phage tail family protein	A0A2H4J7E0	uncultured_Caudovirales_phage	8.3e-10	25.2
WP_057751266.1\|1070768_1075034_-	tape measure protein	A0A0M9JJ59	Lactobacillus_phage	1.9e-21	28.8
WP_151495793.1\|1075051_1075354_-	hypothetical protein	NA	NA	NA	NA
WP_057751272.1\|1075395_1075893_-	hypothetical protein	NA	NA	NA	NA
WP_057751275.1\|1075970_1076702_-	hypothetical protein	NA	NA	NA	NA
WP_057751278.1\|1076740_1077139_-	hypothetical protein	NA	NA	NA	NA
WP_057751281.1\|1077135_1077669_-	hypothetical protein	NA	NA	NA	NA
WP_057751284.1\|1077655_1077997_-	hypothetical protein	NA	NA	NA	NA
WP_057751287.1\|1077984_1078326_-	hypothetical protein	NA	NA	NA	NA
WP_057751290.1\|1078347_1079256_-	hypothetical protein	A0A059NT82	Lactococcus_phage	1.7e-60	50.4
WP_057751293.1\|1079272_1079884_-	DUF4355 domain-containing protein	NA	NA	NA	NA
WP_057751296.1\|1080068_1081007_-\|head	phage head morphogenesis protein	A0A2P1JTW9	Anoxybacillus_phage	1.1e-06	31.9
WP_057751299.1\|1080996_1082733_-\|portal	phage portal protein	D2IZF6	Enterococcus_phage	2.3e-79	38.2
WP_057751302.1\|1082733_1082961_-	hypothetical protein	NA	NA	NA	NA
WP_057751305.1\|1082975_1084244_-\|terminase	PBSX family phage terminase large subunit	A9D9R9	Lactobacillus_prophage	1.9e-134	57.9
WP_057751309.1\|1084218_1084704_-	hypothetical protein	X2CXN2	Lactobacillus_phage	3.9e-48	62.1
WP_057751312.1\|1087115_1087562_-	hypothetical protein	NA	NA	NA	NA
WP_057751314.1\|1087647_1088061_-	hypothetical protein	NA	NA	NA	NA
WP_057751317.1\|1088389_1088824_-	RusA family crossover junction endodeoxyribonuclease	D7RWH1	Brochothrix_phage	1.2e-24	43.7
WP_057751323.1\|1089193_1089382_-	hypothetical protein	NA	NA	NA	NA
WP_151495794.1\|1089381_1089717_-	hypothetical protein	NA	NA	NA	NA
WP_057752051.1\|1089713_1090100_-	hypothetical protein	NA	NA	NA	NA
WP_057751328.1\|1090173_1090962_-	ATP-binding protein	B4XYS7	Lactobacillus_phage	1.4e-36	37.1
WP_057751332.1\|1090961_1091780_-	hypothetical protein	A0A2D1GQ66	Lysinibacillus_phage	1.1e-18	32.1
WP_057751335.1\|1091772_1092435_-	hypothetical protein	A0A2D1GP81	Lactobacillus_phage	1.5e-55	48.1
WP_057751354.1\|1092440_1093205_-	DUF1071 domain-containing protein	X2CXM9	Lactobacillus_phage	9.1e-28	48.8
WP_057751364.1\|1093207_1093759_-	hypothetical protein	NA	NA	NA	NA
WP_057751378.1\|1093891_1094131_-	hypothetical protein	NA	NA	NA	NA
WP_057751387.1\|1094120_1094354_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_057751400.1\|1094388_1094589_-	hypothetical protein	NA	NA	NA	NA
WP_057752054.1\|1094594_1094786_-	helix-turn-helix transcriptional regulator	D2IZX1	Enterococcus_phage	6.0e-05	33.9
WP_057751413.1\|1095376_1095643_-	hypothetical protein	NA	NA	NA	NA
WP_057751416.1\|1095700_1095928_+	hypothetical protein	NA	NA	NA	NA
WP_057751419.1\|1095908_1096202_-	hypothetical protein	NA	NA	NA	NA
WP_057751428.1\|1096266_1096461_+	hypothetical protein	NA	NA	NA	NA
WP_057751437.1\|1096626_1097391_-	antirepressor	Q6J1W3	Lactobacillus_phage	5.6e-70	54.4
WP_083482701.1\|1097584_1097857_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_057751460.1\|1097979_1098312_+	helix-turn-helix transcriptional regulator	X2CXD8	Lactobacillus_phage	2.0e-19	53.7
WP_151495819.1\|1098329_1098623_+	hypothetical protein	D2KRD5	Lactobacillus_phage	6.2e-17	63.6
WP_057751479.1\|1098673_1098994_+	zinc-ribbon domain-containing protein	NA	NA	NA	NA
WP_057751488.1\|1099005_1099320_+	zinc-ribbon domain-containing protein	NA	NA	NA	NA
WP_057751502.1\|1099451_1099661_+	hypothetical protein	NA	NA	NA	NA
WP_057751518.1\|1100164_1101280_+\|integrase	site-specific integrase	C9E2L6	Enterococcus_phage	6.1e-49	34.2
WP_057751533.1\|1101370_1101652_-	50S ribosomal protein L27	NA	NA	NA	NA
WP_057751544.1\|1101675_1102002_-\|protease	ribosomal-processing cysteine protease Prp	D7RWI7	Brochothrix_phage	2.2e-07	32.4
1103154:1103168	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1323278 : 1364868

Erysipelothrix_phage(51.85%)

holin,tRNA,capsid,terminase,protease,head,portal,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_057752144.1\|1323278_1323758_-\|tRNA	prolyl-tRNA synthetase associated domain-containing protein	NA	NA	NA	NA
WP_057752141.1\|1323955_1324663_+	NUDIX hydrolase	NA	NA	NA	NA
WP_057752138.1\|1324781_1326224_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.3e-98	42.5
WP_057752134.1\|1326225_1326774_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.4e-30	43.6
WP_057752131.1\|1326795_1327626_+	alpha/beta hydrolase	A0A220T682	Eptesipox_virus	6.9e-21	27.1
WP_057752356.1\|1327710_1328775_-	hypothetical protein	NA	NA	NA	NA
WP_057752128.1\|1328905_1329700_-	SDR family oxidoreductase	Q06VL0	Trichoplusia_ni_ascovirus	1.7e-08	26.7
WP_057752125.1\|1330653_1331583_-	phosphoglycerate dehydrogenase	A0A2R8FCS0	Cedratvirus	1.7e-23	34.0
WP_057748676.1\|1331965_1333231_-	hypothetical protein	NA	NA	NA	NA
WP_083482667.1\|1334028_1334781_-	HNH endonuclease	NA	NA	NA	NA
WP_057748682.1\|1334866_1335754_-	DNA adenine methylase	R9TL68	Synechococcus_phage	2.5e-13	25.3
WP_057748685.1\|1335935_1336934_-	DUF2971 domain-containing protein	NA	NA	NA	NA
WP_057748687.1\|1336944_1337157_-	helix-turn-helix transcriptional regulator	A0A2K5B261	Erysipelothrix_phage	1.5e-12	57.8
WP_057748690.1\|1337156_1339778_-	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_057748693.1\|1339783_1341091_-	DUF1837 domain-containing protein	NA	NA	NA	NA
WP_057748695.1\|1341440_1341899_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_057748698.1\|1341980_1342184_+	hypothetical protein	NA	NA	NA	NA
WP_057748701.1\|1342167_1342485_+	hypothetical protein	NA	NA	NA	NA
WP_057748704.1\|1342481_1343621_+	DUF2800 domain-containing protein	A0A2K5B2A8	Erysipelothrix_phage	2.2e-110	53.0
WP_057748707.1\|1343598_1344174_+	DUF2815 family protein	A0A2K5B2A9	Erysipelothrix_phage	1.8e-73	73.4
WP_057748710.1\|1344229_1346164_+	XRE family transcriptional regulator	A0A2K5B2B0	Erysipelothrix_phage	2.7e-225	58.0
WP_003671652.1\|1346230_1346635_+	hypothetical protein	NA	NA	NA	NA
WP_057748713.1\|1346637_1348893_+	DNA primase	A0A1X9I6B6	Streptococcus_phage	7.4e-211	48.2
WP_057748716.1\|1349105_1349387_+	VRR-NUC domain-containing protein	A0A1B0RXC4	Streptococcus_phage	6.1e-22	54.4
WP_057748719.1\|1349367_1350723_+	DEAD/DEAH box helicase	A0A2K5B273	Erysipelothrix_phage	1.9e-153	65.7
WP_057748722.1\|1350719_1351187_+	hypothetical protein	NA	NA	NA	NA
WP_083482668.1\|1351333_1351711_+	HNH endonuclease	A0A2K5B276	Erysipelothrix_phage	1.3e-32	56.4
WP_057748726.1\|1351830_1352373_+\|terminase	terminase	A0A2K5B277	Erysipelothrix_phage	7.3e-56	58.2
WP_057748728.1\|1352372_1353599_+	DNA modification methylase	A0A2I4R670	Erysipelothrix_phage	8.6e-153	63.1
WP_057748730.1\|1353671_1354292_+	hypothetical protein	A0A2K5B280	Erysipelothrix_phage	4.0e-42	45.0
WP_003652780.1\|1354294_1354501_+	DUF5049 domain-containing protein	NA	NA	NA	NA
WP_057748733.1\|1354543_1356163_+\|terminase	terminase large subunit	A0A2K5B285	Erysipelothrix_phage	1.0e-246	76.7
WP_083482669.1\|1356257_1357457_+\|portal	phage portal protein	Q6DMU2	Streptococcus_phage	1.4e-152	63.6
WP_003652788.1\|1357453_1358125_+\|protease	Clp protease ClpP	Q6DMU1	Streptococcus_phage	3.9e-59	52.2
WP_057748740.1\|1358144_1359323_+\|capsid	phage major capsid protein	A0A2I4R671	Erysipelothrix_phage	1.1e-125	57.7
WP_003671991.1\|1359339_1359618_+\|head,tail	phage gp6-like head-tail connector protein	A0A1X9I695	Streptococcus_phage	2.9e-08	41.6
WP_057748742.1\|1359617_1360001_+\|head	phage head closure protein	A0A088F713	Idiomarinaceae_phage	5.2e-08	32.7
WP_057748745.1\|1359987_1360401_+\|holin	phage holin family protein	A0A2K5B2A2	Erysipelothrix_phage	2.5e-40	63.9
WP_057748748.1\|1360397_1361276_+	1,4-beta-N-acetylmuramidase	A0A2P1CIJ7	Microbacterium_phage	1.1e-13	30.5
WP_057748751.1\|1361367_1361607_+	hypothetical protein	NA	NA	NA	NA
WP_057748754.1\|1361636_1363298_+	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	6.0e-101	39.2
WP_057748757.1\|1363290_1364868_+	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	4.1e-131	48.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP044534

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection