CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_AP019860	Planctomycetes bacterium SRT547	49 crisprs	cas3,Cas14u_CAS-V,cas14k,RT,Cas14b_CAS-V-F,DinG,WYL,csa3,DEDDh,cas6,PD-DExK	7	10	5	1

1. NZ_AP019860

CRISPR-Cas detection and classification

Crispr_ID: NZ_AP019860_1

• CRISPR_ID: NZ_AP019860_1
• CRISPR_location: 176393-176494
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_1

Consensus_repeat	Method
TCTGGAAGTGATTCCGGTTTTGAT	CRISPRCasFinder

spacers of NZ_AP019860_1

>1.1|176417|54|NZ_AP019860|CRISPRCasFinder
GTGGGAGAAGCAAGTCCTTTTGATACGGGAGCAAGTACTCCTTTTGATCCTACT

CRISPR arrays and Neighbor proteins around NZ_AP019860_1

CRISPR arrays

The CRISPR arrays of NZ_AP019860_1

>merge|NZ_AP019860|1|176393-176494|CRISPRCasFinder
TCTGGAAGTGATTCCGGTTTTGATGTGGGAGAAGCAAGTCCTTTTGATACGGGAGCAAGTACTCCTTTTGATCCTACTTCCGGAAGTGATTCCGGTTTTGAT

>NZ_AP019860|1|1|176393-176494|CRISPRCasFinder
TCTGGAAGTGATTCCGGTTTTGAT	GTGGGAGAAGCAAGTCCTTTTGATACGGGAGCAAGTACTCCTTTTGATCCTACT
TCCGGAAGTGATTCCGGTTTTGAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151966048.1|172448_173216_-|metallophosphoesterase-family-protein	unknown	unknown	gnl|CDD|378975
NZ_AP019860.1|WP_151966058.1|186526_187177_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|375435
NZ_AP019860.1|WP_151966061.1|190132_190861_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966051.1|174459_175422_-|ADP-glyceromanno-heptose-6-epimerase	unknown	unknown	gnl|CDD|187559
NZ_AP019860.1|WP_151966050.1|174023_174497_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966045.1|168317_168836_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966046.1|168846_170196_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl|CDD|235392
NZ_AP019860.1|WP_151966044.1|167910_168297_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013053.1|170382_172317_-|membrane-protein-insertase-YidC	unknown	unknown	gnl|CDD|234942
NZ_AP019860.1|WP_151966059.1|187198_188260_-|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187538
NZ_AP019860.1|WP_151966056.1|184595_185813_-|metallophosphoesterase	unknown	unknown	gnl|CDD|277318
NZ_AP019860.1|WP_151966043.1|166641_167775_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379279
NZ_AP019860.1|WP_151966055.1|183522_184599_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966057.1|185864_186398_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966060.1|188423_190082_-|mechanosensitive-ion-channel	unknown	unknown	gnl|CDD|366370
NZ_AP019860.1|WP_151966062.1|191195_192206_-|zinc-binding-dehydrogenase	unknown	unknown	gnl|CDD|176237
NZ_AP019860.1|WP_151966042.1|165563_166622_+|RluA-family-pseudouridine-synthase	unknown	unknown	gnl|CDD|223638
NZ_AP019860.1|WP_151966054.1|181415_183395_+|4Fe-4S-dicluster-domain-containing-protein	unknown	unknown	gnl|CDD|236630
NZ_AP019860.1|WP_151966053.1|180446_181412_+|carbohydrate-kinase-family-protein	unknown	unknown	gnl|CDD|238917
NZ_AP019860.1|WP_151966049.1|173351_173924_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151966048.1|172448_173216_-|metallophosphoesterase-family-protein	gnl|CDD|378975	pfam12850, Metallophos_2, Calcineurin-like phosphoesterase superfamily domain. Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	5.92391e-15
NZ_AP019860.1|WP_151966051.1|174459_175422_-|ADP-glyceromanno-heptose-6-epimerase	gnl|CDD|187559	cd05248, ADP_GME_SDR_e, ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs. This subgroup contains ADP-L-glycero-D-mannoheptose 6-epimerase, an extended SDR, which catalyzes the NAD-dependent interconversion of ADP-D-glycero-D-mannoheptose and ADP-L-glycero-D-mannoheptose. This subgroup has the canonical active site tetrad and NAD(P)-binding motif. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.3038e-154
NZ_AP019860.1|WP_151966059.1|187198_188260_-|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187538	cd05227, AR_SDR_e, aldehyde reductase, extended (e) SDRs. This subgroup contains aldehyde reductase of the extended SDR-type and related proteins. Aldehyde reductase I (aka carbonyl reductase) is an NADP-binding SDR; it has an NADP-binding motif consensus that is slightly different from the canonical SDR form and lacks the Asn of the extended SDR active site tetrad. Aldehyde reductase I catalyzes the NADP-dependent reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.65755e-86
NZ_AP019860.1|WP_151966046.1|168846_170196_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl|CDD|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	1.41213e-127
NZ_AP019860.1|WP_173013053.1|170382_172317_-|membrane-protein-insertase-YidC	gnl|CDD|234942	PRK01318, PRK01318, membrane protein insertase; Provisional.	1.02236e-97
NZ_AP019860.1|WP_151966056.1|184595_185813_-|metallophosphoesterase	gnl|CDD|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.85988e-21
NZ_AP019860.1|WP_151966058.1|186526_187177_-|TetR-family-transcriptional-regulator	gnl|CDD|375435	pfam17929, TetR_C_34, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in putative TetR family transcriptional regulators found in bacteria.	1.72898e-16
NZ_AP019860.1|WP_151966043.1|166641_167775_+|ATP-binding-protein	gnl|CDD|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	4.46715e-24
NZ_AP019860.1|WP_151966060.1|188423_190082_-|mechanosensitive-ion-channel	gnl|CDD|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	3.19535e-30
NZ_AP019860.1|WP_151966042.1|165563_166622_+|RluA-family-pseudouridine-synthase	gnl|CDD|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.27816e-100
NZ_AP019860.1|WP_151966062.1|191195_192206_-|zinc-binding-dehydrogenase	gnl|CDD|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	1.09429e-160
NZ_AP019860.1|WP_151966053.1|180446_181412_+|carbohydrate-kinase-family-protein	gnl|CDD|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	7.26101e-75
NZ_AP019860.1|WP_151966054.1|181415_183395_+|4Fe-4S-dicluster-domain-containing-protein	gnl|CDD|236630	PRK09853, PRK09853, putative selenate reductase subunit YgfK; Provisional.	2.24271e-119

Protein sequences

>NZ_AP019860.1|WP_151966051.1|174459_175422_-|ADP-glyceromanno-heptose-6-epimerase
MYIVTGGAGFIGSVLVKKLNDRGINDIIIVDNIGTSLKWKNLLGKTYKDYIPKENFLDRVRRGTFPQVKAIIHMGACSATTEEDFDYLYNNNYLYSVELAKWSMREKIRFIYASSAATYGSGANGYVDSQDIELRPLNRYGYSKYIFDQWIKKENLDNSCVGLKFFNVYGPNEYHKGSMASLAYKAFSQIKEYGSLKLFKSHKVPYKDGEQLRDFVYIKDCIDVMLWFLDNPQHNGIFNVGTGKARTWNDLAAAIFKAMNLDYKVEYIDMPMHLRSQYQYFTEASMDKLTKMGFSQGFRSLEEGIRDYYENYLLQENPYL
>NZ_AP019860.1|WP_151966050.1|174023_174497_-|hypothetical-protein
MKITYYKKILICNFALCLLLISCANKDRYVISDSRVVKYRSPIDPVGHLAGNFAKNPTAPSYRQFFLSWFAEHRNLENSLGKSVLAVVDAHHNIQNALSNMHTFLDENKKQKLQAYQKLYDTLLLALRRNTSLRILTTRYRALGKSINEEFSPTATN
>NZ_AP019860.1|WP_151966049.1|173351_173924_-|hypothetical-protein
MWYKIDKEGFSREELIRLYSVVETRTRGFREDLFRFTNFYSAVCFAILGITLSGFVNFYGKGFPVLFFLFGPVTTIMMCFLGLRVTNQIYRRIQQETSMKAKIENALGLDQAMPIEKFYGEKVIWENDNSLIPTRHAERRFLESDSSDFVNAGSRKKGGVNKNNKLYFGIIGAVSVLLIVTIIVFAMKQV
>NZ_AP019860.1|WP_151966048.1|172448_173216_-|metallophosphoesterase-family-protein
MIALISDIHANIEALTVVMEDINKQNVDTIFCLGDVIGYGPNPRECIEIVRNCSEFTLCGNHEEAVLFSAQDFNVKARRAIDWTRDQLNSDKYDQEENYELWDFLGELRKKVKDESVLYVHASPRQPTREYVLPKDIKDQNKMESIFMEFENCGVCFCGHTHIPGVFTDDLKFEYSRNLGNRFEISSYPGKKLINVGSVGQPRDGDNRASYVLFDVENQIIEWKRLPYDYKKTMEKIRAVDDLADYLAVRLEEGR
>NZ_AP019860.1|WP_173013053.1|170382_172317_-|membrane-protein-insertase-YidC
MTPEKRFLLAMSLSLLFLMIWGQVMVKKRQAALKKRQEQQQQVQQNNNAQNNNDAQKNDNAQKKEQNNNENNNENNNENNNENNNENNNENNNKNNDENNNENEKQQQDIEDEKFVVETPKYYMTWTNKGGSLVSLKLKEYVTGDTDKKKEGWQNNQENWLDIIPEFNTRHLSLTFANNTGNKEKLSASSLSSLLWNVINETDKNPRRLIFTKTDNGVLYKKIFTFTDENIIKGEVVITNTKDQKVTCSPAIGGSSGISWECADKTVSQFITLHHFYRNHKGNPVSSYEYLDTATADDFSIQNNFSWLSIDNKYFSTVIEAVNPKEVSGITSQSFSPDIFYIQKNISAKREKGETPNEKDLKAIKLFAPILQFASFDLAKGESKTLQFHFRAGSKVDLAKDNKEFTLLEDFGMFDFVARFLLAVATLFAGIFGNYGIAIICMTICIKLILFPLTKKQQLSMQKYQKSMKVIQPQLKKLQQKYKNNRQKLNQEMMALYKKHNVNPIPVGGCLPIFIQIPIFIGLYQSLQYSILLRQETFLWVTDLAQPDRFMLVDWSLFNSVFGDYLNILPIIMTVLWILQQKLMPRPESPEMQQQQKIFMFMTIFFGFLFYSLPSGLVMYWLTVNLISIGEQLIIRKLKEKQEA
>NZ_AP019860.1|WP_151966046.1|168846_170196_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MNNSTIVAVSSTSGESYRGVIRISGPEAFTITSKFTVEEIKPQKHKWCQSDLLIEQWQMNIPVILYLMKAPFSYTSENIIEIHTFSSPVLLDIIVQQFIMGGCQPAQPGEFTKRAFLSGKMDLTQAEAVAEIIAAKTTAERKSAFLGMTGQLSRQIEEMQAVILNVVALMEAHIDFSDEEIDPLPADYVLENLQPVFDLLCSFHKKNKEVSLHGIQLCICGAPNAGKSTFFNLIVEKNQALVSDVSGTTLDWVEDYIVIDGIRFNVIDTPGLEDKAVDLQHKAQKKGRDILRNCDIALFILDSSTPYKEVYEQLFAIIPHETPLAILYNKVDLPSQIDQQIFMDKCDTIFSTSFTTTQNLDTIKSWLVAKAEQIKQNKNEILLNTRQHFAVKQTATILEQVIDDLKNATSYEFIVGDLRLSLDYLGEIVGKVTTEDILGEIFSKFCIGK
>NZ_AP019860.1|WP_151966045.1|168317_168836_+|hypothetical-protein
MPLKIRCSCGAILLAPEERIGQTGKCPSCNRSIAVDLSMSKTQEIMHKLELEKTQRMEQQQLSSTQPMNSNIAKKSLIHKMLALLIYIVFLALVFGITILHYSEDIRTVEIESAVLKDTWEDCKEPLYEIREIHRAWFRKMFGGKNTSNDSSEMVERKINELWYKKVILQKQ
>NZ_AP019860.1|WP_151966044.1|167910_168297_-|hypothetical-protein
MKIKFKCECGKRIKTSVKKIGRQLHCPLCQRKVTIPKIDSEAVLNLECDECKIPFSNNLDKCPSCHKIVEEENETTQEEFNHNRSSVIISPKNPANLYYIVWGVCIIISLISIVYIIVNLKTLKSIIG
>NZ_AP019860.1|WP_151966043.1|166641_167775_+|ATP-binding-protein
MQNVTTNFSYDAEDKRIGIISISGMIDLSNVGDFSQFLDKVLEVTCNILIFNLSGLTYMNSTGFGALTSRAMNEPKFKIIFCNLESNISEVFSMFGLDNVCDILPDLESAMEVAKTLVEDGTYDRESSIEEIEELEDESERELHVEEEQNTSQVTTEATNATANSAARMPTPTDGTPSTHVQFPTIKRCLSCGKKINFRTTGHYRCPRCKSILFINNEGTLNLIENPLSPSLPAVPENEGAPDEITIIFPSDTNYLSKIRDFIMSFTKATFDDQQRDSITMAVDEACSNAIEHAHHFDRNKKIHMSVLINEEFFSITITDSGVNTFSEHLVQPDDDQIKKSGRGMGLILMRRMMDEVNIRKTETNGTSISLVKYAKA
>NZ_AP019860.1|WP_151966042.1|165563_166622_+|RluA-family-pseudouridine-synthase
MERPLVPNYEKLDRFDFVVPAGATNCRLDQYLVNCFSQYTRSFITKLIKNGDITVNGNTVKPSSKIKVGHRIFISLPQLEPLELKPEAIPLDILYEDEYMAAVNKQPDLVVHPVKGQNGGTLVNGLLHHFANLSEINGYIRPGIVHRLDRFTSGVILIAKTNYAHAFLAKQFENREIQKEYIAITEKPIECKKGNISLPIGTDPRCREKMCVNHGGRPSETNYEVLCNYAQFSFVHVFPKTGRTHQIRVHLKSLGNPIVADDLYGANPNLTVDDILKSFTGENVKYEKQLAEENLCGTLIDRQALHAWKIKFIHPQTKKEMLIHAPLPLDFQKVLKALNILWPNTVVDKFLS
>NZ_AP019860.1|WP_151966053.1|180446_181412_+|carbohydrate-kinase-family-protein
MPTILVTGSLAYDYIMHFGDTFSKHILADKIDKLNVSFTASDLSKNRGGTAGNISYSLALLKETPVIATTVGKDFDEYRTFLEQRGIVTSEIVVLENEWTASAHIITDLNANQITAFHGGAMLANDFCIKPTLDKFDIKIAIIAADGKTGMLRHAETFRNTNTKYIYDPGHSLPAFNGEEIMSLLNGSHIVLVNSYEADLIVDKTGKSLEELRQLVDYFIVTLGGEGSVIYHKDEETKVAVVKTDNFVDPTGAGDAYRAGLLKGLVNDLPMETCGQLASTAACYAVECTGTQNFAYDAESFIARFSENYGQNEDVVKLFNG
>NZ_AP019860.1|WP_151966054.1|181415_183395_+|4Fe-4S-dicluster-domain-containing-protein
MAELIPYSFGKLVTRIFREWEIQKSIFDIKQKSFFHTPENLDFSIQFHNKRAATPFGPASGPHAQMAQNIAMSWLCGARIIELKTVQILDELDIPRPCIDVPNVGYNVEWSQELKIEESLHEYVKGSMLIDILKHSGIVSWQERDLDTVLDISLGYDLKGIQSDKIQHYVSKMRDASDIVDLYRQQIPQEYAHLRDIPFTTKIADSVTLSTFHGCPPDEVEKIASFLIREMGLNTIVKFNPTLLGKAKLREILHERLEYTDLVVPDKAFDDDMQWDQALGICERMKKLATDCGVSYGAKFTNTLIVENYRKVFAEKEEVMYASGAPLHVLAIQIVSKFREHFGNEIPISFSAGIAPNNFHHAASLGFKPITVCTDLLRKGGYARSAKYFQALAKDMKKHNCNDIPSYITARAQENDSEVSSLSQALKVNSLNYAAAVADPEGEYHQSKHTKTPPKPGTKMKIFDCLTCDICIPVCPNHANFSYFLEKGSVPVTKFVRKNSMWEKQESGEVSVNKRHQIANFADFCNECGNCDTFCPDLGGPYILKPRFFSSLEQWQEDKQFDGFFLKKTSDEETLWARFDGNEYTLKVANDHQDSTADLPPCEFNYRGKTFRMTSEGIQGDAAEGTEIDGTYLIWMNLLRRGVNRSEQVNYAMLSGDCC
>NZ_AP019860.1|WP_151966055.1|183522_184599_-|hypothetical-protein
MTAQNKILCTRLLQTLDSEERFGVPYGTTSPFHFGFRDFAFSHPGSRSHKYYIDLRSYHSIRGYRQAVAELYKDEKIEIEVNGETRKFPIQIISIPVEDQRKLQEIAEKNNYEGELLKQEDEELVFISSLPSPRLLGVPPKGKSRSDYLQLKTNKVIDIAIITRQSNEKEGKKALAKEISKCLAPIEPTLAFATKTAQYLANAMPKPVGISLRGTIADNPVVFEDSFRVPVSGKNFYEITKEKSWPTLDIDLDIFCGEEDFQEIYETLCDEHLFFEVNAEIKGLNLHSQMQEKLFYKEKNLRSIDIYLMTEEWVMKSVQRHLNLGFEQPWAYYYFNSHALVFDDWVNFLKSLNRHIFN
>NZ_AP019860.1|WP_151966056.1|184595_185813_-|metallophosphoesterase
MKKFAVVVVLFLCIHAENYTYLTWEQHDIHNHITVHFFSPNKRFPSLLVNYSSDKQQGTQPFVETGIPFIDNVYVRSTVGGSVTKVKNKYQYVYHTTLHNLRAGCEYTFRLHDHSKNFEGKTKKFRTPPLQKIRLIAGGDMGYADTEIVPILQQAAAKAPDVALIGGDIAYANGEKKNLPRWISWFKHWQDNMVSKEGHLIPMILAIGNHEVDRVLLWKQAPFYFGFFFQGGKPYFTRKIGKHATLIVLDTDHIYSYSSQRRWLKKQLQKYNNSTFKIAMYHVPLYPAHRDFDNSDSVTARQLWLPLFDQYNLDIGLEHHDHVFKRSKRLKNNRVVQQGGTIYLGDGSFGRRPRSVEKRYYIEKALQAKHFWFLEIDTNRIFIQAVDDNGKTLDQFTLDKKGENQ
>NZ_AP019860.1|WP_151966057.1|185864_186398_-|hypothetical-protein
MYLLAFSVSENLMNILSLSGSIVAAILSAFIFFRTSNKERPRILIRQTSKVQPAQDVWKTGEVFRNYFETSFIIANQSSLPNALLGVKSFFQIDGKWVEDDIMTAEKTPLPQNIQPLCTVPFQVSAVKWIEGEPGKDNAERAESHPSLPDNLKIRLQFEMLSGKPVNVDMEYQRKAK
>NZ_AP019860.1|WP_151966058.1|186526_187177_-|TetR-family-transcriptional-regulator
MTWERARTEQQKQQRIQEIIDATARLYQERSFEEITFALIAKEAKFTRSNLYKYFNSKEEIFFEFLKYDIVTWRKDFVSSVCDKAFSVEEFAEMWFEVQQRHLRMQDLISILYAHLEKKSSLETLVSFKKMVVSEFGILCGVLQSIFPKLSVANAIKFLQIQLALSIGLYTMTDLSPTQEKVFEITEFAHLKMGYPQYFKQSLVYMLRGLINDSKV
>NZ_AP019860.1|WP_151966059.1|187198_188260_-|NAD-dependent-epimerase/dehydratase-family-protein
MNIDKTKPVMVTGATGYVAGWVVKRLLEEGLVVHAAIRQPENKEKTKYLDEIAANSPGSIKYFKADLLTPGAYAEAMQGCQVVFHTASPFFLDVKDAQKELIEPAKMGTRNVLEDVNKTESVKRVVLTSSCAAIYGDNRDLYNAPQQTLTEEVWNTSSSVEHQPYSYSKMLAEKEAWDICKEQDRWDLVTVNPSLVLGPGINPFGTSESFALIKQMGDGTFKMGTPNWAIGVIDVRDLAEAHLRCAFIPEAKGRYIISAQSSSFPHIASILREKFGKAYPFPKKSLPKAMVWLFGPIVNPGLSRKAISYNVNHPWKADNSKSKKELGMEYRPLQESLADFFQQMIDNGYFNKK
>NZ_AP019860.1|WP_151966060.1|188423_190082_-|mechanosensitive-ion-channel
MLVDILKLLDISPDIFHVFFVVVIAVGCFALFLLVRVVDFVFFRRKLQKQVWLIDLICLPTLISMIDIFVYNFFGGNAQVYLTTRNVTNSFLWLLFAWFFCRGMEIFIWTAFFKKLTGEECPRLLTGFFSALVYFATFYIILTVVYKKALASLLIPTGIIAGVLGLALQSLISNVFAGLVIAVEKPYRVGDWIELPNGMSGRVIDITWRTTRLWSRKNGIYIIPNDMATSNAVHNHTILDNKYSEWYYIDIDGEVSPNVALELLTQAALRCEKVLKYPAPVVTIHDITSRPYKYKIQVYFEDHAAHWYGKNELLLRIQNTLIIHGIAPSETRIEINKLEEPKINIQTPRLETYLRRAHLFKSLSDDDLRIISINSEKKEYYPGEMVIVEGDEATALFVIAYGMLRVLKKDHTGTNQAVAELSAGTEFGEMSLLTGKCRSASVEAVTNCVVIKVPKGSMKELLDRKPHLLSMLIERMVERRMNSEGMLDKLSKDASKTQFLNYTKELFSTVAAFFDLPSRRATKIMRESPLASPSRETEKLDRETIEEKKKNK
>NZ_AP019860.1|WP_151966061.1|190132_190861_-|hypothetical-protein
MNNISKEGMQSTAIGFVGALVVFAFPFVTFIFSNLIILVHEMGHAAFGILFSYPSIPAFDFRYGGGVTTIQSRSTFFIFIIYLLFAVGLLKISNYPRLLKAAVVAIIVYSFCAFTSIHQQIILFMGHGTELIIAGIFLYRGLSGSAVIHKIEQPLYSMLGFFIVFYDMRFAYRLAYVESYRIQYGNAKGGGHWMDFSQLASWMQISLSSMAFFFLLCCILPVVLSALAHLYREKILAFISKA
>NZ_AP019860.1|WP_151966062.1|191195_192206_-|zinc-binding-dehydrogenase
MRSIQIQESFGLQQLKFNDCSEKPIHDDEIEVSMHAASLNYRDLLMVKGLYDPKQPLPLVPCSDGAGVVTATGKDVCDVAVGDFVTTVFAPYWQSGTPTTTQMRGTMGGPIHGALTQRFVAKSSHVMKAPKHLNAVEASTLPCAAVTAWNALVEVAKIKAGDKVLIQGTGGVALFALQFSKICGAETVVLSSSDEKLQKVKEMGASHTINYRTTPKWSRAVRDCVGQVDIVIELGGAKTLEQSLKVCRPGATIAVIGILSGIKNEINLLPIIMNKINMSGILVGSRSCFESMNKAIAHHKLQPVIDKTFAFSETIQAFEYMESAAHFGKICIDLQK

Crispr_ID: NZ_AP019860_2

• CRISPR_ID: NZ_AP019860_2
• CRISPR_location: 500740-500819
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_2

Consensus_repeat	Method
TTCTTCTTCGGATTGGTGCCCTCACC	CRISPRCasFinder

spacers of NZ_AP019860_2

>2.1|500766|28|NZ_AP019860|CRISPRCasFinder
GCAATTATGAAGATTTGCGATTCGGGAT

CRISPR arrays and Neighbor proteins around NZ_AP019860_2

CRISPR arrays

The CRISPR arrays of NZ_AP019860_2

>merge|NZ_AP019860|2|500740-500819|CRISPRCasFinder
TTCTTCTTCGGATTGGTGCCCTCACCGCAATTATGAAGATTTGCGATTCGGGATTTCTTCTCCGGATTGGTGCCCTCACC

>NZ_AP019860|2|2|500740-500819|CRISPRCasFinder
TTCTTCTTCGGATTGGTGCCCTCACC	GCAATTATGAAGATTTGCGATTCGGGAT
TTCTTCTCCGGATTGGTGCCCTCACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151966265.1|504865_505615_+|1-acylglycerol-3-phosphate-O-acyltransferase	unknown	unknown	gnl|CDD|153251
NZ_AP019860.1|WP_151966267.1|506758_507328_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966256.1|489966_494091_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966258.1|494766_495939_+|CIA30-family-protein	unknown	unknown	gnl|CDD|369941
NZ_AP019860.1|WP_151966270.1|511719_512166_+|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl|CDD|273242
NZ_AP019860.1|WP_151966261.1|499298_499955_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213227
NZ_AP019860.1|WP_173013077.1|509982_511410_+|DUF2330-domain-containing-protein	unknown	unknown	gnl|CDD|370813
NZ_AP019860.1|WP_173013076.1|507494_509954_+|DUF2330-domain-containing-protein	unknown	unknown	gnl|CDD|370813
NZ_AP019860.1|WP_151966255.1|485758_489850_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966254.1|484604_485726_+|hypothetical-protein	unknown	unknown	gnl|CDD|238141
NZ_AP019860.1|WP_151966253.1|483257_484514_+|phosphopyruvate-hydratase	unknown	unknown	gnl|CDD|234617
NZ_AP019860.1|WP_151966272.1|513643_515347_+|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223587
NZ_AP019860.1|WP_151966260.1|498517_499225_+|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|274173
NZ_AP019860.1|WP_151966264.1|503104_504862_+|hypothetical-protein	unknown	unknown	gnl|CDD|379383
NZ_AP019860.1|WP_173013075.1|501258_502827_-|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224154
NZ_AP019860.1|WP_151966262.1|499957_500731_+|iron-export-ABC-transporter-permease-subunit-FetB	unknown	unknown	gnl|CDD|377092
NZ_AP019860.1|WP_151966271.1|512541_513408_+|outer-membrane-beta-barrel-protein	unknown	unknown	gnl|CDD|341091
NZ_AP019860.1|WP_151966266.1|505623_506640_+|TauD/TfdA-family-dioxygenase	unknown	unknown	gnl|CDD|367137
NZ_AP019860.1|WP_151966257.1|494233_494752_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379112
NZ_AP019860.1|WP_151966259.1|496194_498264_+|hypothetical-protein	unknown	unknown	gnl|CDD|376628

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151966265.1|504865_505615_+|1-acylglycerol-3-phosphate-O-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	1.33321e-39
NZ_AP019860.1|WP_151966256.1|489966_494091_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.07297e-100
NZ_AP019860.1|WP_151966258.1|494766_495939_+|CIA30-family-protein	gnl|CDD|369941	pfam08547, CIA30, Complex I intermediate-associated protein 30 (CIA30). This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation.	1.3278e-52
NZ_AP019860.1|WP_151966270.1|511719_512166_+|Rrf2-family-transcriptional-regulator	gnl|CDD|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	2.51875e-30
NZ_AP019860.1|WP_151966261.1|499298_499955_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213227	cd03260, ABC_PstB_phosphate_transporter, ATP-binding cassette domain of the phosphate transport system. Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD).	8.27758e-40
NZ_AP019860.1|WP_173013077.1|509982_511410_+|DUF2330-domain-containing-protein	gnl|CDD|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	1.65699e-25
NZ_AP019860.1|WP_173013076.1|507494_509954_+|DUF2330-domain-containing-protein	gnl|CDD|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	9.55756e-26
NZ_AP019860.1|WP_151966255.1|485758_489850_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.15769e-97
NZ_AP019860.1|WP_151966254.1|484604_485726_+|hypothetical-protein	gnl|CDD|238141	cd00229, SGNH_hydrolase, SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.	4.43323e-05
NZ_AP019860.1|WP_151966253.1|483257_484514_+|phosphopyruvate-hydratase	gnl|CDD|234617	PRK00077, eno, enolase; Provisional.	0
NZ_AP019860.1|WP_151966272.1|513643_515347_+|DEAD/DEAH-box-helicase	gnl|CDD|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	9.50104e-145
NZ_AP019860.1|WP_151966260.1|498517_499225_+|PEP-CTERM-sorting-domain-containing-protein	gnl|CDD|274173	TIGR02515, Putative_DNA_transport_protein_HofQ, type IV pilus secretin (or competence protein) PilQ. A number of proteins homologous to PilQ are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). Members of this family include PilQ itself, which is a component of the type IV pilus structure, from a number of species. In Haemophilus influenzae, the member of this family is associated with competence for transformation with exogenous DNA rather than with formation of a type IV pilus; the surface structure required for competence may be considered an unusual, incomplete type IV pilus structure. [Cell envelope, Surface structures].	0.000240159
NZ_AP019860.1|WP_151966264.1|503104_504862_+|hypothetical-protein	gnl|CDD|379383	pfam13810, DUF4185, Domain of unknown function (DUF4185).	0.00931493
NZ_AP019860.1|WP_173013075.1|501258_502827_-|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	3.62799e-55
NZ_AP019860.1|WP_151966262.1|499957_500731_+|iron-export-ABC-transporter-permease-subunit-FetB	gnl|CDD|377092	pfam03649, UPF0014, Uncharacterized protein family (UPF0014).	2.00418e-95
NZ_AP019860.1|WP_151966271.1|512541_513408_+|outer-membrane-beta-barrel-protein	gnl|CDD|341091	cd16858, ING_ING3_Yng2p, Inhibitor of growth (ING) domain of inhibitor of growth protein 3 (ING3), Yng2p and similar proteins. ING3, also termed p47ING3, is a member of the inhibitor of growth (ING) family of type II tumor suppressors. It is ubiquitously expressed and has been implicated in transcription modulation, cell cycle control, and the induction of apoptosis. It is an important subunit of human NuA4 histone acetyltransferase complex, which regulates the acetylation of histones H2A and H4. Moreover, ING3 promotes ultraviolet (UV)-induced apoptosis through the Fas/caspase-8-dependent pathway in melanoma cells. It physically interacts with subunits of E3 ligase Skp1-Cullin-F-boxprotein complex (SCF complex) and is degraded by the SCF (F-box protein S-phase kinase-associated protein 2, Skp2)-mediated ubiquitin-proteasome system. It also acts as a suppression factor during tumorigenesis and progression of hepatocellular carcinoma (HCC). Yeast chromatin modification-related protein Yng2p, also termed ESA1-associated factor 4 or ING1 homolog 2, is a subunit of the NuA4 histone acetyltransferase (HAT) complex. It plays a critical role in intra-S-phase DNA damage response. Members of this family contain an N-terminal leucine zipper-like (LZL) motif-containing ING domain, and a well-characterized C-terminal plant homeodomain (PHD)-type zinc-finger domain.	0.00455738
NZ_AP019860.1|WP_151966266.1|505623_506640_+|TauD/TfdA-family-dioxygenase	gnl|CDD|367137	pfam02668, TauD, Taurine catabolism dioxygenase TauD, TfdA family. This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from E. coli is a alpha-ketoglutarate-dependent taurine dioxygenase. This enzyme catalyzes the oxygenolytic release of sulfite from taurine. TfdA from Burkholderia sp. is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase. TfdA from Alcaligenes eutrophus JMP134 is a 2,4-dichlorophenoxyacetate monooxygenase. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1.	4.64732e-25
NZ_AP019860.1|WP_151966257.1|494233_494752_+|GNAT-family-N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	1.04077e-32
NZ_AP019860.1|WP_151966259.1|496194_498264_+|hypothetical-protein	gnl|CDD|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	1.17114e-26

Protein sequences

>NZ_AP019860.1|WP_151966262.1|499957_500731_+|iron-export-ABC-transporter-permease-subunit-FetB
MQVIEISMWQLFLCLILVMITGFCSIMLHLKLEKDLLIGTTRTFVQLFVMGYLLKFIFQINTYYLVLAFFTWMIFWAAHAVKGRTKERTIPLLFPTFMAMLVSCMLVTIIVTSLVVQVKPWYKPQYFIPIGGMIVGNSMNGIAVALERMLSEMRKQRDEIEMFLCIGANCQEATASIVASSIKAGMIPSINALMTVGLVTLPGMMTGQILAGVNPMTAVKYQIIVMLMLTTSTAISCIILIHVVRRICFTPAQQMKI
>NZ_AP019860.1|WP_151966261.1|499298_499955_+|ATP-binding-cassette-domain-containing-protein
MKIEFKDVALQYAKKEPLFREVNFSVCHEDYVIIRGSSGTGKSSLLRLMNRLLEPSSGEIFVDDKPLYTYEVTHLRRKVTYLQQTPIIVEGCVAENLLLPFHLVSATKPAPSKEELRKWLDDLLLKDVCLDDDAQKLSVGQKQRIAFIRCLLLEPSLLLCDEPTSSLDPTAKDILEQCLENYHLEKNIGIVLVTHTDVKVQKAQVKKYILDSCRLREL
>NZ_AP019860.1|WP_151966260.1|498517_499225_+|PEP-CTERM-sorting-domain-containing-protein
MKILLKAMVIFVVVLLPLQAVPIVNNTFTGQEILNSPDASFPNVVQPSLDGTSLRFDNPVNNDILLDFDILQSGQVLAEGSTVTAVVNVSQNFGDFDPSFGFIDGSGTSAGFQVANNSGGRGSIGGTGLGLTTVFNNAGLPGTFDITLSVSTNGGVSTASLAFGTGSGNLNLAVPLDLETGLSFFLVGNGGDTSPYLINSLNVTVDGNPIPEPTTYLSLLIGMLFCGFVVRKRKK
>NZ_AP019860.1|WP_151966259.1|496194_498264_+|hypothetical-protein
MLYKNKYLILVVVSLSFLMADWSQKRSLYYKFSMNNQVMGYVEVQVLPKSDHVEVHSRTFIQASLMGQSFDVKATEMMKLSSDGKRQYFDSNVTQGETQLGSTVSIKDGFIHFTSKSGGEEKKIEAAGVTFESYPYYRNIVKDLGDGQKHTYRVFSDQTGEVEDVTYQKKREEEITLAGKKYQAIVASYYNKNSGQTQEIWYEVESGCVLKTQLPGNVEIAIADPNILGKIKRVEIDDLLFARVNVSITDYTKITYMKLNVKIRTAGEIVTPESLNVPGQSFRGKVVDNVIEGVFEIAHAHYDGKDAPAFPTTYDKELQTYLQVEQQIEADDSLLIDHAKKITAGAKDSWDAVRKISRWVSENISYKIPGGSARQTFDSKTGECASHSRLVTALCRGVGIPARLASGGMYTPLYGGSFGQHVWNEVYMGKAGWIPIDSTANEIDYVDSGHLRIGNLASFNPQNITVEEHRILEQKATDLVSQTKAPWEIGKEYTYSYSYQGKKLGTDSFRIVSFKDGVYTCENKLAMTGLNSHGTWKLHEDMRPISYKLEGKTPQFAYTLDCAFSKDKVVEKVIKGMWPVTKTVPLQGDHYLFDNSNLGTLAMIVTKIPRKEGEKAVVKIFHPSSIRVLTLQIEVGKQQNITVNGKEYSCWMVDISLAGMPLKVWVDDTGRILRETENAGNLVIELQNP
>NZ_AP019860.1|WP_151966258.1|494766_495939_+|CIA30-family-protein
MYKYFLLFLIMIWTIMAQETIFSFTEKNNGWYSVNDNVMGGISQGGAKMTAEQTMMFSGELSLKNNGGFSSIRSPFIKANFKDYTGIAVRVKGDGRLYYFNIYTDVRIPAGSYRSTIQTIPGKWVELFLPFSKFQATSFGRKIPFFPALNKNKIKRMGFMAADKKEGNFALEIAWIKAAKKLSDDAPKLLNSADWLQKNGSTSVFWSLVEGTSFEKLLRRDLSCTIFAVVDESFATYPKKRLEMLRRNHFARNFFLATHIRVGRIPLTSQIIPSRVPAFEVSEKNIYVANGIIHTGTATSSALKTFLQKMSRTEFIQYVISIGSATFNVGYPEICQDIYYLGLLFIMQNFDTTEELRNEIDKALQLDEKNSSGKAWEFRYLLDKIYALGD
>NZ_AP019860.1|WP_151966257.1|494233_494752_+|GNAT-family-N-acetyltransferase
MSVVKTTRLNIRKLCMDDAAFMCALLNDSEWRRFIRDQGKRTIEDAANYIKNSAMQSYQDLGFGLFLVELKTAVPVGICGFVKRDYLPDVDIGFAFLPQFRKKGYAVEAASVLLSYAQQHLGMSRVAAITQKENLASIKVLEKIGLTFEKQIVCDAGQQLQLYSINFKKLDT
>NZ_AP019860.1|WP_151966256.1|489966_494091_-|protein-kinase
MMAQHEKNILQFLVSKNVLTTAQAMSIAQNRAQMHESQPSTNIVTFLLQHNYITPAMAQKLQEMLAKNDKQTGQKPQVNTDGVVVSPTTGHMPQISSHTSQHNFDNTAMDLKMNPHTRQTSHKNNTQKNYSSQEITTYTDETVYPQSPKYSDQQISDSQLGNVDSQFGKGHTSTQDFRVSQFGEENGDKRMFRHYRIERELGRGGMGLVLLAYDTKLDRRVALKVIINEQNIAEEQIRRFSLEARATAKLKHPNIVEVYEAGNTPKNYFTMEYIKGYPLSGLIQKGNLKAKDIATIIKKCCDAIYYAHKEHKIIHRDIKPSNIMMAGDEPKIMDFGLAKEMDRDDELSRDGGMMGTLGYMPPEQIDNDNVGHHSDVYALGATLYNALTGRPPFQGSSYYMVLNQIHNDDPIPPSQLAPGTSKELEAICLKCLQKKPRHRYRNAKELADDLSNFFSNRPVNAKPPSLPVKAYKWYKRNKVKTLVSMTFMLSLITIIVLVIVNNASLKKAYQQTQRQKIKAEQAQQRAEQAQQRAEQAHKDAEKKKEDAIQQLVGAMESKRSSVVKQYQLTIMAGQNAARKNRREVTQKHLGNFEKQEKNYIELLNAARSKDYYDELRKIIPPNSPVSFDLTQDNKQVYKRGWEWQWLKTIASPKLNIKFKHPYAILSCVYHPQKEQVICGDQNGNIFSVNLPLSKQNPTYIWRSKLFDSQQKIKGYHPATFIHKLAISPNGKYLLSYGEDKNRPLSVRPDFRLLLWDIQQKKIIGQYRNHTQDYPDPGRNTIEPTEFIFTKDSQNFFVGYQQANVDSGFQVFNNRKKLVPRFANALMWSVKNDRKPRHQFFLYLNKQKGDGIDHSVTCLDLSHDGKILAVGRESAPMPVVLVNLKSKKELILKGPLGQVLDICFSGDSRYIITGDNEGEIFIWNTKTGKLMRKLLAHDGKMSRCVTHRNILTTTAEDNTIKLWDLDKIRLSNMLVGSFSEQNTEDLFIDRRQQKIVLTQQLNYLKSISLDSIMNPSRLPGSHNNFQHVRFHPQNSRAILTATTYKYFSWQMDAKPIQLNLLRAYDTVFHKNNHILGIPLGAQASTLFVKYDQQNFVKKLQSVSLVKLKDPDISKVIAVPKKPSAVAFHPTENKALIGLSYNRDKVKRLFFPNGAYFGREILYFYDLSHQNPRLLWSSYFHREIDMVDISNDAQQMLILSANYLYLKNLYRVDADIKRNQRVYGRMHPDFRQKNKYKNFLLQNNFRDSMYLRRLNRKLLHACFSPDSKYIAVAAVGTINNLVILDAQNLSLVANLKDHLDDVRCCNFSPDGTRLVSCSADKTVRIWDVENLQLGDERNSLLTLRKHTSSVAHCVFSNDGKNVASCGQEELLVWKTK
>NZ_AP019860.1|WP_151966255.1|485758_489850_-|protein-kinase
MIAQYEKNILQFLVKKNVLTTAQAMHVAQSMPQIRQSQPSVSIVAFLLQQNYITQVMAQKLQEMLVQNQKQTGQMPQVNTNQTMVSPTTGQMPQVNVNQTVVSPATGQMPQMTSDNNLEQTAVDIKINPQQTIHAPSDQQVNQNYQEITTNIEETAYPPSPGYADPQIGNSQLGNINSQLGKGQIATQEFRVSQFNEENANDKRMFRHYHIERELGRGGMGLVLLVHDTKLDRRVALKVIINEQNISEEQIRRFALEARATAKLKHPNIVEVYESGETPKNYFTMEYIKGKPFSALIQKGNLKAKDIAAIMKKCCDAIYYAHKEHSIIHRDIKPSNIMMDGKEPKIMDFGLAKEMDRDEQLSHGGGMMGTLGYMPPEQVDNDNVGHHSDVYALGATLYNALTGRPPFQGSSYYMVLNQIHNDDPIPPSQLAPGTSKELEAICLKCLQKKHRSRYRNAKELADDLANFLYNRPVNAKPPSLPVKAYKWYKRNKVKTLVSMTIAFSLITIIVLVIVNNASLQVAKQFAENAQKNAEAQTKQAVRQLAAAAESERSSVAKQYQLSVISGQEAARKNNREVTQKYLELFDFQEKKYIERLDGARSEDYYNQLLDTLSPDSPVYLDLTQNNKQVYRRGWEWKWLETIAYTEFSTQFEHERTILSCVYHPQKEQVICGDHQGNIFSLNLPLSKQTPTYIWKSEFAKPQQKFTGYTPDTYIEKLAISPDGKYLLSYGVPRNKPVKPNYRLLLWDLHQRKIIGQYTHYLKDYPKKGINTMKPTKFVFTKDSQNFIVGYEQVELDEGFQVFNKDRNRKSVPPFANALIWSVKNHNKPQHKFFLYKKVDDHRDHSIKSLDLSSDGKLLAVGTGSDIMPVVLIHLNSKKKRILTGPKEEITNICFSDDNRYIVMSDEQGGIFIWDTKTGKLVRNFVAHGGKISRCVVQNNILVTTTADTIKLWDMDKIRLKNMLLNSFSERTKDIFIDRNQQTITFAQASNYLKSISLSSIMNPLALPGGHNNFRYSRFYPQDSSHLLVATKYKFFSWKIHSKPTQFNLIRAHEAVFNKKNTILGIPLGAKVSTLFIKYNQQNLMKQLQSIALNNPEGDSFTINAQPKKPSAVAFHPKEDKALIGLSYNRGRVKSLSVRGEFLGRELLYYYNLDNRTPQLLWSSYFNREVDMTEISNDAQQMLVMSGNDLFVKSLSTVESDIKKNQTKYREIYLHFKNRGQEKKFLLEKDFRESEYLKQHGRKLLYACFSPDNKYIAVAGAGATNNLAIIDAQSLDLVVNLKDHLDAVRCCNFSPDGTRLVSCSSDKTVRIWDVTNLKTTAKEERNSLLTLHKHTGPVEHCIFSHDGKNIASCSQEELFIWKTK
>NZ_AP019860.1|WP_151966254.1|484604_485726_+|hypothetical-protein
MKKKFLLAFTSFIVFFLLCEALTYAVVFLGIRPKYYVSDIVENYPKYSWNMYSGPLLQRKKNSYIFWGALFNNPNKVTINKYGLRGPTIAKPKKDKTLRIMFLGGSHVFDLAAPENKDWPNMVATYLKTNQKIEIINAGMPGKSSHDNLARYYLDLHTWKPDILVFSGAWNDIRHFHNISPESSIIQLHAYDTLPSSPSALVYNYNTLDYIFGWSLFYSKLRHNYYSSKSFFETKRQKAKKLHDTFSKFAVEQYKFNLEMLYHACKITNSKLVLLKQSRLPHRNNGKVEKSKINYHARFLTHKALCKAFDLCDQVMDTLQEKYDDIEVIETSHLCGKVDYFYDAVHTSSLGSQKIAQVVAKNLQTFLQDDENF
>NZ_AP019860.1|WP_151966253.1|483257_484514_+|phosphopyruvate-hydratase
MKITNVSAMEILDSRGNPTVRAYVTIDNKITGSASVPSGASTGIHEALELRDGDDKRYCGKGVQKAIANIHQRIAPQLVGMNPFNQREIDMAMLELDGSKNKEQLGANAILGVSMATAVAAAKACNLPLYKYLGGVGAFRLPVPMMNILNGGEHADNSVDLQEFMVMPIGAPSFSEALRYGAETFHALKKILKKKNYATSVGDEGGFAPNLKSNDEACELILEAITQAGYTPGKDISLALDSAASSFYKDGSYDMHWSGTGKKTTDEMIALYQDWMEKYHIISIEDGLDENDWDGFNKLTAAIGKKVQIVGDDLFVTNKEFVQKGIEQSSANAVLIKLNQIGTVTETVETIQLCRKAGWNYIISHRSGETSDTFMADLCVAMGGGQIKTGSACRSERIAKYNRLLEIERELTSAALFC
>NZ_AP019860.1|WP_173013075.1|501258_502827_-|NAD(P)/FAD-dependent-oxidoreductase
MSEKTFGKELPEKKWDCIIVGSGMGGMTCAAMLSKLGKKVLLVEQHYVPGGYTHTFPRKNWRWDVGVHAVGEVTKHSMVGRVLSRLTDDRLQWASLGEAYDEFHFPDEFRIDFPDTPQKFRENLLHAFPEEQKAIDEYLKQVKTVAKNMRNYYLSKGLPGIFSRFLGKNAQQFFLQKTQQVLDSLTDNKRLKTIIASQWGYYGSPPSRSSFAMQALVAKHFSYGGYYPVGGSQQIATELLQTVANSGGWTKICTGVSQIIVEKKRAVGVVLEDGRKVYAPKIVSAIGAIETVNHLLPQEMDNHAWVKSIQTLKPSAAHVCLYLGFKGDIRQAGASPANKWFWETWDCEFESWDFRDPRALAPVLYTSFPSLKDPQHDPGKQMFHTGEVVTFVPFAEFAKWQNERVMKRGDDYNALKEELSDRLKKQLFKYMPQLEPLVAYSELSTPVSCTHYTRAAKGAIYGIEPTPQRYANPWLKPRTPLKNFYLSGSDVSTVGVIGAMVGGVLTALAVEPWKTMAFIRRN
>NZ_AP019860.1|WP_151966264.1|503104_504862_+|hypothetical-protein
MKNIIVISLLSVFLQALPGYFTIEIVDKDTHRGIPLVELRTVNDVVYHSDSNGIVAFYEPGLMNNNVFFHIKSHGYEYPKDGFGYRGIRLDITPGGKKRIAMKRINVAERLYRVTGQGIYRDSVLVGKSLPSSSVINSNVMGQDTVMMAKYRDKLYWFWGDTNRVSYPLGNFKVSGATSIVSDPDHGIDLHYFRENDFCKALCPFAKRGVVWIESVVVLEDDTNRERLIAQYEELKDLTTVLQRGLVMFDDETQVFKPLSVFDLQDLYPRGHPFRAMVNNEEYLFFAHPHPQPFPNVRVKATLKDIQQPDNYEVLVKNERGFIWKKGKKCLEAKSDDWIFLRDMHSEKQLHMHAGSIFWNPYRKRWILIGQEAGGSSSFLGEIWYAEADTPIGPWVYARKIVTHTNYTFYNPTQHPIFDKENGKIIYFEGTYTNTFTKVPVTATPRYNYNQIMYRLHLDDERVYLPCPVYENGSEFSFKEKASQYDTIAFFALPADREKSSAVAIYQDGSRLTTNKMSGEPLFYAAKNNAIHTTALCEYQNRKSAKYHYSVKELPSEEWKKVRTVCRVWKNPTRSTYDYSIKPQE
>NZ_AP019860.1|WP_151966265.1|504865_505615_+|1-acylglycerol-3-phosphate-O-acyltransferase
MLRFLEKVIRILLAFVIFASTSLFFLVVCFLLLPFRTLRTKICLFYGTVMGKTVLYLLKVHPVIKDKHLLRESFPALYIANHTSTLDLFIGGWLAPIGTVGISKKEIVFVPFFGWLYYLSGHLLIDRSNREAAIRSMEKIVKQAQRDNLGIWIWPEGTRSKDGRLQVFKKGFAHLALNSRLPIVPIIIHDAHKRWGKQTGFNFIKEPLKIEVLPKIDTSEWRLETLDEHIASVREIYIKYLGEDQQPNS
>NZ_AP019860.1|WP_151966266.1|505623_506640_+|TauD/TfdA-family-dioxygenase
MYQKITGPCVWYAEDLQQSSTWQFTLSSEELQEIDTAIHQVDNLENWQQLTPQNFSLPQTAKKLQHIQKFIEEDAGLALLKGFPREKYNVQQITAIFWVLAQHIGHPISQSADDDKIFSVRDAGFPVGHPKSRGPNTKNKLSFHTDRCDVISFFCVEKAKEGGENLIVSSPAIHNEIQEKHPHLLPVLYNTFYNKRHNVDAGNSKPFCELPIFSQHEGHFAANIMRVLIFRAHEMEETPDLSPLQKEALELLEEMAADPKMHIRFTQEPGDILFVNNFITFHSRTEFEDHELDEKKRHLLRIWLAVPNSRPLSPLFAPNYGNTNAGAVRGGMKPHLYK
>NZ_AP019860.1|WP_151966267.1|506758_507328_+|hypothetical-protein
MRSSLIMCAICICSLVYLWATNENENKSLNIDKPRVDKKASDDCGCAPQISTSGCVTGCGAIPDTTPAITKDEFMKHLQAFANSPIDEQSLDLETLLFYGKETRKWLPEQSILDEDHLRFLQRELQKTHAEIQLRVIDDEGNVRIELEPRIVEIGQKYHEHIHTTHDMQELEISGTIKRVGVHHLWSRF
>NZ_AP019860.1|WP_173013076.1|507494_509954_+|DUF2330-domain-containing-protein
MNIRNTIVCMVFTCLLYADPCGMVPPIHTTGNNAITRIGLQKTYVFYKDGLQTVVIRPGFSGKVDQFGMLIPFPSPPSLRKVPDNIFEHIAASIDPPEVVVNVNRRLRMLKETTSQHLPSSAPLSYKNEVKVLKQEAVGMYEVTVLEAGSAAALKRWMDQHGYRYPTGMDKACEDYVALGWCFVAVKTRVGQKQGVAARPGMRNVNSKLPKGSSFDGHVQGMGFRFYTKKMVVPMRLSAFNGDNFRNIVYILTDKPCAIEKIPTKFVRRQISGEKLYNNLTKLLPVRIIGRANRAFIERRVQEVRYLRNPQPRNGLAAELYSADLLALREKKLEHDHEEQEKALLRISENLLLRGKAIDKLHGEVIAKQRQKIVEFALEEIKNMTLTVVDGDFPKEVIANHNLSFRRYEMSSTNNNTEKYDAKKCAPGGKMYGELFVPQQQPKKSGFVNSIWFLLGGLFLLLLCKKFPRMLHTACVLVLCTAIFAPNLHADNDGDEVYKLIQQLDDYKKTSSIMQQLVKMGQKAVPHLLGEAVEGSDMVQRGWAIVCLSQIGGSTVDAHLQNIHQNQKQPMLVRTWAIAARIQMTQSLGEVMDMSQHLSQFPALERPIGKRVMALLASEDNVSAEKLLGLAQRMPKLQGVLGKVITGLDSKELVQAMATAKDQQVRRLAAGYLASMAQNNNKIPYEVASVYEFKVDAKDVPWANGPLFVPGLRWDRESSRTLVGSLISWHLWCERKGKKAEQRQIHNNIRSLSLAQAAGYESPAWNEIGTDQWLLVWGKAVGQKELLRLLKEQNVQNEKRYIEILKQLSQQKVQEREQW
>NZ_AP019860.1|WP_173013077.1|509982_511410_+|DUF2330-domain-containing-protein
MKKCLIAFVATFSLLWSDPCGMVPPIYTGEGPAITRIGLQKTYVFYKDGVETIVIRPGFSGKVDQFGMLIPFPKPPELRKVPDNIFAQIAAAIDPPEVIVDLYPYDEYEAMEDGGVDDSMDEKSLEYDTVKVLKEEAVGMYEVAVLAAGSAKALSRWMDTHGYQYPKGMDTACNDYIKMGWCFVAVKTRVGQQKGVAARPGMRDVNSKLPAGANFDGNVQGMGFRFFIDKPVVPMRLSTFNEGSLRNIVYILSEKSCRINSIPQKYVVRQVSGEDLYRNLTQPLPLRIVGGSVYDISESYWQSLMSQRDPKVHNAMAAELFAGDLLAASIRKLAHDYEEKEKMFLRIGEALNLRGPNIDALNIGQLEKERKMIVERALADIKSMTMTVVDGDFPREVLANENLTFSDYTMTENNDGIKYNARFNGKRNDYYAQEGTVYRGAQRPTKKSGATWWLLAVLLALVVCGRKTLQLRSQS
>NZ_AP019860.1|WP_151966270.1|511719_512166_+|Rrf2-family-transcriptional-regulator
MLSKTSVYLIRALVELAKLPPDTYSGAVNIAKKIGSPQNYLTKTLKILVQNQILTSQKGFGGGVRLARDASDITLAEVIEPIENLQQQPHCIMGQNRCSEKHPCALHNQWKKIRAEHQKMLENTTIESIVNFYKNKDYSNGLYEKIIN
>NZ_AP019860.1|WP_151966271.1|512541_513408_+|outer-membrane-beta-barrel-protein
MKVKIIVLMICVMGLSFASDDLLSEIRAMKEQIQQLQNTVKQQQQTIDSLMSGSSRTIPSQQSGKAPATYEEIIAELSSAQENTSEDLFDSRAESGFLRGNAFYLKMGITYDPFQNGWGWVIGGALDLKLADFETSSLLGTIGIAFSKSKDTKNVVTSDALGVDLLNQEVRLTTLTVDLNFKYRLDNVWQEGSALRRFQPYVRGGAAMQVFISDSDGNIGGQVPQAQQLNDSNFPAGQGNMYAAITGGVGFDFMLTKMLFVGLDYGAYFLFIDKGYSSNLAFTVGTRF
>NZ_AP019860.1|WP_151966272.1|513643_515347_+|DEAD/DEAH-box-helicase
MTTFSEFGLSSELLQAIEQIGFQTPTQIQQKAIPFLLENHRDFIGLAQTGTGKTAAFGLPIIQKIHREKIPQALILSPTRELCLQIAKDLELFCKYKKNVAIVTVYGGAKIDPQINKIKKGVQIVVATPGRMNDIIRRKKVDLTNIKTVVLDEADEMLNMGFKEELDAILQHTPTTKNILLFSATMPKQVIQIAETYIHDPYEVTVGKKNTGAETVDHAYYVVRGQDRYEALKRIADIHPDIYGIIFCRTRAETKLIAEKLIKDGYNADALHGDLSQEQREFVMGKFRKKNLQMLVATDVVARGLDVENLTHIISYNLPDDLETYTHRSGRTGRAGKKGVSIAIVSRREIEKIKRIERSIHKQFERRQVPNGHEICERQFFHLIERVKNVEVNEEQIAPFMNKVYEKLEAFTPEEVIKHFVALEFNMLLDYYKNERDLNVPYRSKDQNKNKQRSKNKEKHSTKFQRLFINVGRKNNVRPQDIISLVNDISGKRRIPIGEIDISKSFSFFEVPPHEAHELTSTTVYLDDKEVQIRKADSKESKDSGHRFKPNHTVGKKSKKQKRKRKK

Crispr_ID: NZ_AP019860_3

• CRISPR_ID: NZ_AP019860_3
• CRISPR_location: 779168-780037
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 11 spacers
• Cas_protein_info: Cas14u_CAS-V

Consensus repeat of NZ_AP019860_3

Consensus_repeat	Method
AGGTTTGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAAT	CRISPRCasFinder

spacers of NZ_AP019860_3

>3.1|779210|27|NZ_AP019860|CRISPRCasFinder
TCATTTTTATGTAAATAAAGTTCTTTG
>3.2|779279|96|NZ_AP019860|CRISPRCasFinder
TGATTTTGGGACAATTCCAGGTGAGTAAGATTTTGGAGTTGACCGATCTCTTTTGGTAAGTCTACTAAATTATTCTGATGCAAATAAAGTTCTTTG
>3.3|779417|27|NZ_AP019860|CRISPRCasFinder
TGATTTTTGGACAAATCTAGGTGAGTG
>3.4|779486|27|NZ_AP019860|CRISPRCasFinder
TGATTTTTGGACAAATTTAGGCGCGTA
>3.5|779555|27|NZ_AP019860|CRISPRCasFinder
TGATTTTTGGACAAATCTAGGTGAGTG
>3.6|779624|27|NZ_AP019860|CRISPRCasFinder
TGATTTTTGGACAAATTTAGGCGCGTA
>3.7|779693|27|NZ_AP019860|CRISPRCasFinder
CGATTACCGCGCGAAACAAGCCTCTTT
>3.8|779762|27|NZ_AP019860|CRISPRCasFinder
TTGTTGCGAGATAAAACGAGATCCCTA
>3.9|779831|27|NZ_AP019860|CRISPRCasFinder
TGGTTTAATTGCAAATGAAGTTCCTGG
>3.10|779900|27|NZ_AP019860|CRISPRCasFinder
TGGTTGTAGTTCAAATTTAGCTTCTTG
>3.11|779969|27|NZ_AP019860|CRISPRCasFinder
TGATTGGAACCCAAATTTAGGTAAGTA

CRISPR arrays and Neighbor proteins around NZ_AP019860_3

CRISPR arrays

The CRISPR arrays of NZ_AP019860_3

>merge|NZ_AP019860|3|779168-780037|CRISPRCasFinder
AGGTTTCGAAATTGTCCTATTCCCTTTGGAATCTCTGTTAAATCATTTTTATGTAAATAAAGTTCTTTGAGTTTTTGGAGTTGACCGATCTCTTTTGGTAACTTTGTGAATTGATTTTGGGACAATTCCAGGTGAGTAAGATTTTGGAGTTGACCGATCTCTTTTGGTAAGTCTACTAAATTATTCTGATGCAAATAAAGTTCTTTGAGGTTTTGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAATTGATTTTTGGACAAATCTAGGTGAGTGAGGTTTGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAATTGATTTTTGGACAAATTTAGGCGCGTAAGGTTAGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAATTGATTTTTGGACAAATCTAGGTGAGTGAGGTTTGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAATTGATTTTTGGACAAATTTAGGCGCGTAAGGTTAGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAATCGATTACCGCGCGAAACAAGCCTCTTTAGGTTTTGTAGTTGGAATATTTTTTTTCGTAGTCTCGTTAATTTGTTGCGAGATAAAACGAGATCCCTAAGATTTTGGAGTTGTGCTATTTCCTTTGGTAGCCCTGTTAATTGGTTTAATTGCAAATGAAGTTCCTGGAGATTTTGCAGTTGTCCTATCTCTTTTGATAACCTTGTTAATTGGTTGTAGTTCAAATTTAGCTTCTTGAGATTTGGGAGTTGAACGATCTCTTCTGGTATCTCTGTGAATTGATTGGAACCCAAATTTAGGTAAGTAAGATTTTGTAGTTGCCCGATCTCTTTTGGTAGTGCTGTTAAC

>NZ_AP019860|3|3|779168-780037|CRISPRCasFinder
AGGTTTCGAAATTGTCCTATTCCCTTTGGAATCTCTGTTAAA	TCATTTTTATGTAAATAAAGTTCTTTG
AGTTTTTGGAGTTGACCGATCTCTTTTGGTAACTTTGTGAAT	TGATTTTGGGACAATTCCAGGTGAGTAAGATTTTGGAGTTGACCGATCTCTTTTGGTAAGTCTACTAAATTATTCTGATGCAAATAAAGTTCTTTG
AGGTTTTGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAAT	TGATTTTTGGACAAATCTAGGTGAGTG
AGGTTTGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAAT	TGATTTTTGGACAAATTTAGGCGCGTA
AGGTTAGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAAT	TGATTTTTGGACAAATCTAGGTGAGTG
AGGTTTGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAAT	TGATTTTTGGACAAATTTAGGCGCGTA
AGGTTAGGGAGCAGGCCTAATTCTTTTGGTAGCACTGTTAAT	CGATTACCGCGCGAAACAAGCCTCTTT
AGGTTTTGTAGTTGGAATATTTTTTTTCGTAGTCTCGTTAAT	TTGTTGCGAGATAAAACGAGATCCCTA
AGATTTTGGAGTTGTGCTATTTCCTTTGGTAGCCCTGTTAAT	TGGTTTAATTGCAAATGAAGTTCCTGG
AGATTTTGCAGTTGTCCTATCTCTTTTGATAACCTTGTTAAT	TGGTTGTAGTTCAAATTTAGCTTCTTG
AGATTTGGGAGTTGAACGATCTCTTCTGGTATCTCTGTGAAT	TGATTGGAACCCAAATTTAGGTAAGTA
AGATTTTGTAGTTGCCCGATCTCTTTTGGTAGTGCTGTTAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151966445.1|767260_767857_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236608
NZ_AP019860.1|WP_151966449.1|774003_774957_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966459.1|788847_792117_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966446.1|768209_768524_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966455.1|782123_783314_-|GTP-binding-protein	unknown	unknown	gnl|CDD|223597
NZ_AP019860.1|WP_151966463.1|796359_797517_-|DJ-1/PfpI-family-protein	unknown	unknown	gnl|CDD|153235
NZ_AP019860.1|WP_151966454.1|780393_782091_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966460.1|792128_792830_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013099.1|776781_777438_+|IS607-family-transposase	unknown	unknown	gnl|CDD|239738
NZ_AP019860.1|WP_151966458.1|787443_788838_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl|CDD|335469
NZ_AP019860.1|WP_151966461.1|792829_793954_+|glycosyltransferase	unknown	unknown	gnl|CDD|340831
NZ_AP019860.1|WP_151966450.1|774967_776419_-|hypothetical-protein	unknown	unknown	gnl|CDD|239068
NZ_AP019860.1|WP_151966456.1|783325_785167_-|hypothetical-protein	unknown	unknown	gnl|CDD|341067
NZ_AP019860.1|WP_151966448.1|769767_773892_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966443.1|761169_764538_+|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966457.1|785420_787433_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966444.1|764828_767111_-|DUF3160-domain-containing-protein	unknown	unknown	gnl|CDD|378649
NZ_AP019860.1|WP_151966447.1|768568_769726_+|hypothetical-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_173013100.1|777343_778978_+|transposase	Cas14u_CAS-V	-	gnl|CDD|284650
NZ_AP019860.1|WP_151966462.1|793988_796172_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP019860.1|WP_173013100.1|777343_778978_+|transposase	Cas14u_CAS-V	-	1.8e-20	68.3	7.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151966445.1|767260_767857_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	1.5997e-53
NZ_AP019860.1|WP_151966454.1|780393_782091_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.03293e-72
NZ_AP019860.1|WP_151966459.1|788847_792117_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.99423e-33
NZ_AP019860.1|WP_151966461.1|792829_793954_+|glycosyltransferase	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	4.19699e-36
NZ_AP019860.1|WP_151966455.1|782123_783314_-|GTP-binding-protein	gnl|CDD|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	4.71528e-103
NZ_AP019860.1|WP_151966463.1|796359_797517_-|DJ-1/PfpI-family-protein	gnl|CDD|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	5.32405e-66
NZ_AP019860.1|WP_173013099.1|776781_777438_+|IS607-family-transposase	gnl|CDD|239738	cd03769, SR_IS607_transposase_like, Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.	1.21261e-44
NZ_AP019860.1|WP_151966458.1|787443_788838_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl|CDD|335469	pfam03781, FGE-sulfatase, Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins required for post-translational sulfatase modification (SUMF1). These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD). The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase. Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases. FGE is localized to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesized sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilized by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidized cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase.	1.9994e-54
NZ_AP019860.1|WP_151966450.1|774967_776419_-|hypothetical-protein	gnl|CDD|239068	cd02248, Peptidase_C1A, Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, primarily for bulky hydrophobic or aromatic residues at the S2 subsite, a hydrophobic pocket in papain that accommodates the P2 sidechain of the substrate (the second residue away from the scissile bond). Most members of the papain subfamily are endopeptidases. Some exceptions to this rule can be explained by specific details of the catalytic domains like the occluding loop in cathepsin B which confers an additional carboxydipeptidyl activity and the mini-chain of cathepsin H resulting in an N-terminal exopeptidase activity. Papain-like CPs have different functions in various organisms. Plant CPs are used to mobilize storage proteins in seeds. Parasitic CPs act extracellularly to help invade tissues and cells, to hatch or to evade the host immune system. Mammalian CPs are primarily lysosomal enzymes with the exception of cathepsin W, which is retained in the endoplasmic reticulum. They are responsible for protein degradation in the lysosome. Papain-like CPs are synthesized as inactive proenzymes with N-terminal propeptide regions, which are removed upon activation. In addition to its inhibitory role, the propeptide is required for proper folding of the newly synthesized enzyme and its stabilization in denaturing pH conditions. Residues within the propeptide region also play a role in the transport of the proenzyme to lysosomes or acidified vesicles. Also included in this subfamily are proteins classified as non-peptidase homologs, which lack peptidase activity or have missing active site residues.	1.3561e-65
NZ_AP019860.1|WP_151966456.1|783325_785167_-|hypothetical-protein	gnl|CDD|341067	cd09604, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains bacterial M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0.00705602
NZ_AP019860.1|WP_151966448.1|769767_773892_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.98168e-88
NZ_AP019860.1|WP_151966443.1|761169_764538_+|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.6946e-75
NZ_AP019860.1|WP_151966444.1|764828_767111_-|DUF3160-domain-containing-protein	gnl|CDD|378649	pfam11369, DUF3160, Protein of unknown function (DUF3160). This family of proteins has no known function.	1.67209e-72
NZ_AP019860.1|WP_151966447.1|768568_769726_+|hypothetical-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	2.08472e-39
NZ_AP019860.1|WP_173013100.1|777343_778978_+|transposase	gnl|CDD|284650	pfam07282, OrfB_Zn_ribbon, Putative transposase DNA-binding domain. This putative domain is found at the C-terminus of a large number of transposase proteins. This domain contains four conserved cysteines suggestive of a zinc binding domain. Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesize this domain is DNA-binding.	6.57024e-12
NZ_AP019860.1|WP_151966462.1|793988_796172_+|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.34159e-98

Protein sequences

>NZ_AP019860.1|WP_173013100.1|777343_778978_+|transposase
MSEEKKDKIKNGQVLAYPIVIEEKKVAEKLRETLEYVQQKSNEYLEFAHENRLYNVFDKNKSKYSYKVLEPIFVKLYRQSKLPSRINRGVLEIVGRTMRQVRDRKRVFDLLMKKTQDPKKWTSKLLVKDGIYIKIDYIKNIKEQVINYKRKNNNELPQDFYALQKPPKVKKKILTYAPDDGQAIKIEKKNNKVVVSFKVIDRKNGAIKWYWLKTNIKLPLFLEDKHITSPDIRFECVRGNYLPVLDFKVTIEKPQKIESGNFITFDWGVRKLTTLCVFNEKGQQLSQPHFVNFSRVQDKLQRIYKDIDHWKSKRDKLAHKDSLFKKCNREIAKRWSKITTLNKEIAHTTANIIVFFAQHFNCSKIYCENLKSLKSQKKSKDKNREINTTVRQKIMSLVDYKARLCGITLAKPVHPAGTSSLCPRCSHKGQHIKASDNKQKIHKTFSWFHCAKCKFSADRDYVACINIARKVLFKKNLKKCTKTVVYKKTRLPDSLFRQDAGAKTHCTSHIHYLKGWIHSVSLSSIVVQKSFNSFKGTIFGILRV
>NZ_AP019860.1|WP_173013099.1|776781_777438_+|IS607-family-transposase
MAWISIGKVAALFGVTTQAIRLWTYEGKLSARRTLGGHRRYNLEEIEKILGIESKNKKTVLYSRVSAHDQKEDLLRQKKELRDYIEKQEHCNVVEISEIGSVLNYAKRGLKKLLNLILSGGVRRIVVSYKDRLMRFATQILEQVCAAKNVEIVILNERPQKKFEEAVVEDVLCVLTVYCAKIYGRRSHERRKKRQNKKWSGTGISHSDRRKESSRKTT
>NZ_AP019860.1|WP_151966450.1|774967_776419_-|hypothetical-protein
MKKTIYLLASFLLAQIVFAQQVQKIDKFYLQRENKMSVVLKQKIQTLRSQKISQKWSFNVGYTTAMDRSLTQLAGLKAPGNLGQSIQLQNAKSTKAIQLLPKQTPDAIKKLNSFFVLRRWDWRTRGKVSPVRNQRACGSCWAFATIGAFEGNDRLRNSRSIDASEQCVLNCSGKGTCRGGWWAFDFLINKGVASEARYPYTANDKPCNNSIPKYYKAIAWGYVKGMNPNVTDIKRALLRYGPLAVAVHVSPAFQAYTGGVFNHNVNKSVNHGVTLIGWDDTKRAWIIKNSWGSGWGSTAGYGREKGYMYISYNCSRIGYAAAWVLSKKMPTPRKEDCIPFNPARIKVVNIKRRWKIVDGRSWLKDFGSNRAEAVKALAIMKRYRLNKMCFVGRPNPSMEYYLVNGKSPVGAFPGEDAIRFNPRTIRVQFIKGDWKIVDGRSWLMSFGKKKNEAYEAYAKIKKYGFTHMCFVGRPNPSMTYFRK
>NZ_AP019860.1|WP_151966449.1|774003_774957_-|hypothetical-protein
MKKFCIFVLCLSCIAADEKDILGGYTQVAVNDAYVADVIPTVCDLFCKTHEGYVFVKAQKAGYQIVAGTNYYFALQFRHNKEKVIVKLYAHKTLDGKTSIVKIISIDKSVLGGYEALSKDSSEAKNIIATVTSKLEKHGYFVESTHAIGKQIVAGTVYCMEMQLSYHSLKLPYKVYAYKKLNGDVSITKIEGHVSDMDSLGKIMKNSCIKARETAMSSGKMQYIEIACSKNTCKVNTSKVMYIVSHITKIKPEEILVVYSFDEKGNVLLVGGKLEDGSYSPTRTHEKAHVVFIGKKQRCLFSVDPKGKKIQYKIESN
>NZ_AP019860.1|WP_151966448.1|769767_773892_+|protein-kinase
MDDYQTKELPSDNTWHGYQIIKEIGRGGMGCVYKAFQTELKRTVALKITLTASSQTSNRRFVREMKIAAQLDHPNICKIYDAGIIDDKKYMVMDYIEGLSLKEYLKQHDLSVEEKIRLMMKICAALSYAHQRKIVHRDLKPENIMMDKNNEPIVIDFGLARRVDSSEFDLTKTGDVVGTPYYMAPEQIAGLRKNITHQVDIYAMGVILYEVLTGKRMMEGANVFEVMCRIHDRNYVPLRVQNPELSRDLQTIWEKATYPERKYRYANIDLLSLDLQAFLNNKRVKKSPHKQMRMLSYGLAILCITMITFLFMPRNDRLLVNIKLSRAAKERLQERLRYFEAILTHIDKREFDVAEHKYKARRLSPSQYITLVKELYEKNEYDRAFALLSEVEDRVVAKYYKAIILYHKQQYKLAEKILRKLPGYANKNYYLGLCLYHIARKYNKFDLFGEVLTLLEKKKYQDDINVLVALAAIHRYRKSQVAKEYFQKCVAKEPFAAKHSVPLARIYIQENRHYDAFVLIRKILDSDNTLNAYEVLHEIPYYEPTLNRFCYQTVVNGFFRDIQLHTPHLFLQQCVAVQQGYRERYTSWLRLQVPQQSSLATIFDKLPNASLEVQKLLKKAMMNLRYSRNFHQQIENFIAQDITPQIENFLREVQKQARREKDKEIMAMILYRLARIEQNRAWSQSEWRHSDMDTLFHYVLSNGTSVFEKYLLVKGILHFYGVAPLIKILHDDGKDAILRTIVAATFREYHLAAKIDVFFQLPQMQERISSAREQEFFKILIARSMYVTHAYKHLDTFYRKINYKERRTEVSRKERDLLLYLMTDSSLKVRVIAAGSLHGLMDERQDAKTVKMSRDVLTRWGMRATQNVVRAYSHFIFWQKKQVIQPEYLPLYRAGLQDPSMEVKKTVLGFHLKVGSYIPKISKELEKCLTLSPEIRRLALFALVMNKRSKKLIFEEKFYPSIAKDFLPVEHSMVFLTTLYRIMDDFKSTNKIDFSTIKKLIDFMNYTKTYIHSLPPSSQCMISYILTMFNVHTDHAYLDKINDPFLLSYLLFQLQQEAIFSNQMPKGFVKSPTLKERKDIAKEYLKYPHAKVKQFATTSYISLGDENVGKNYVRIAKKWPKLKRFVALGIRGFTERRWLKKVKVGPTVAMWSSAETLYVKSLRQTHQFLNSAKNSHEKNKAMRWFDLMCSLDPKGDKYFFERAYFFNQKDALADVNKAMEINQDYRAGYLKLYYSLEGLTIAIRRRENTDLYLQKLRKQSLHPSLFSEVANAYVIVGKLEEALSVYERNFFATQGNFELFSEIFTRDLQMVNIYLKQKDRKTATVMLEYLYQIFRRGNYTTNKRQKFFVKMVKEKLPNFVPFIDNWSQEREVLE
>NZ_AP019860.1|WP_151966447.1|768568_769726_+|hypothetical-protein
MEKKIEDIFWENNIFEQRVKGKSLLQIESDTFYEGCAFYLNEEECYCIEDSYFYNCSFRGNVHFSGLEGCKFDNCNFCGTFALDFSESIWPDKHFCSLYDLTKLNLRDSNMCTLPWKFRFLVNLCELNLSDNAMGYFPPEILFLDKLCYLDMSENGIEFIPKEIVQLQQLSVLNLSYNNLYDVLSPNLCELRNLEELNLTSNYIRHLPEEFAKLQKISILNLEYNTLSRVPLAITKLQNLKFLNFSYNRIRNLPKEFEQLQNLRTLRLARNQISSFPEEIFLLTNLQSLDLSINLLPSIPEEIGQLEKLRHLRFVDNQLKQIPLELCRLQNLETLDLSDNDLRHLPSEIHRLKSLRLLYLKNTGIGWWQRQKIKSWLPNCEIHWQ
>NZ_AP019860.1|WP_151966446.1|768209_768524_+|hypothetical-protein
MSDIWVEVETNKGTNNVNSYRGKLSKKNFEAILAQRSGWICLQETYWVAEYHDHGENRMMAQGTLLGRDGIFAHFHGDTYLRAEHIVSISPVDGEEDRRQFLGT
>NZ_AP019860.1|WP_151966445.1|767260_767857_-|sigma-70-family-RNA-polymerase-sigma-factor
MTSGKNINCDQQNHEEFLIKKAMAGDKSAFGMLAGKYKNKLYSLLYYMVHNQDDAMDLLQDTLIKAYKSIHNLRSPNAFYSWLSRIGVNLTLNFLKKNEKNKQYREKLALEYKAQTESPLQSLEKKELQSKLTKLISQLPAKQKAALVLCDIEGYSYKEISEILECNVGTVMSRIYYARDYIRKQITSYNCDAIKVPK
>NZ_AP019860.1|WP_151966444.1|764828_767111_-|DUF3160-domain-containing-protein
MKCENLEILLSGYVDNQLSQEQKVYVEEAINSNDTLRQKVEELHNVKQQLSTLVAPLPTDCSWDNFNTDLWEKLDEKKPTGMSLVQKFLFVAALFVIVTVSLFLPNFYTTNTFSLEYTPLIGLPEKSEVEHEVVKVNASIPKYEVPINIRYLKEANLSQREIQFLSQKGFVVTKNRFGSFNEIYENNQRNSIPSYVTVDTAISGFSHILGRLRIDVEEKALYGRLASFTEVIGHKLINLHKKIAPQHEKASLRALAFIRVASILLDLKQQWPEEITSKINKQVQEELTLIYTGGNDYPVEIVNSPIFGYAMDYSRFKLLRKPKNKRLERYIIAHEWYARCLFRTADHYSKVAEQYLSETRSAMLLLIATIATDGMSIWEEIHYILTALYGQADDPHLLDYLKTARDVYGPTITLDVLSQKDKLLEFCKAISRTRLPKIRSELGLQSGLRIFSRRSIGCDFILQQLTYPYVGELHLPRVDPSLLDIAVIMGWHKAKYIAEDKGYYEYKGYKSTVRKYQDRLEKELQPVNYPWGKGGLISLAWMLNSLKIPEGKGAPIFSHSDEWQARKLTSVACGLLDLSFGQPVFTGKSTADFHGTIEPYPEFFNRMATKIEHFEEVLHHIGYPLQTGVAKELVHYKKMLKELAVISSKMLENKELSDKDYKKLCNFVLGWQGKYGSATIQDISTMYYRNSSNFDNHLYAGVGAVYEMWVAIPVNGKVQLARGGIFGYHEFQSMKKVSQEKWQQLSPRPGLASWISEYAY
>NZ_AP019860.1|WP_151966443.1|761169_764538_+|PQQ-binding-like-beta-propeller-repeat-protein
MELDLGTRLNGRYSIKRVIGQGNMSYVYEAFDDLLQRPVAIKQMVIPHGAWDSASFIKRFRREFHFLSAIEHPNVIKAYGFFSEANTAFMVLEIVKGPSLQDLIVKRAQMHVSLSMNLAIAIQLSRAIEVINTAGIIHRDIKPTNVIINDVNKKLKLLDLGVATTVKSELSRLTNHGHIVGTPDYLSPEQINGEYASNSDVFSVAVVLYQIFAGDDKSPFHNENPMSTMMSISTKELPSLLDISNLSSELYRQTYVKIWAVLEKALIKEPEERMSSATEMADEFEMIYKGYRLAKSRVKEKKSQVVNWNVIEKTKPEEFQKLKKLGDKFGRDDTPLRKRRRRTKSKRTPRYQAEKKSTPVVGFLVMAVFVLATALFLFIHFAETEKIPPKKSIAQQKSEMFERLLLQIKTLKTPDKWSRVNNFNLEHSFAKSLAKKEQLERDIFETLINANAFMNSNNSPSTKQLKKWEDIYFWKQNIAFLELYRNESKIKQQFELFEKHFSDVEKNKINSYTLENKIGVEVYRKRNLKNVREILNAMSNVSDLQKKIIKQYHEEIDTLENVLVAFKRKMRSLRGKDVKVVVGKKWLKVKVLEVEDNYISIKKGSKTSKFYLYNLDGEMRQLDARNFAYHVRPKLAKQIYCYALLFYYGKNYKTAYKYLLRCVNYSQATYFLHRTYRKIYSQPLFKMDVLKPQKIEDEDVLNVTTNRDTISLRGKILINKNVTTKAKKDIISGITINVNGKKARRRNNEFALSFPVEYGKNFIDVKLSIHSDKEILRKSFYVERDFPRTRNFSNTNFFPSLSGEFQVLNWQNHYGKNLGIPVVLKQHVYVKDHSNILYKTTINGEMVWKKDNVSALTYDEIKTSTKNIYEYFLYISSPDQLVCYDESNMQPLWEKSLSDVIYPGIILKNYIVFATATTLHAINYKTQKQLWQKTIAPATKAILANNSAYFAMQNGEVISYRIKDGKKRIALATGSPISSAPTTSGHTIFVGNHQGNFYAFFQGKKLWKYSSSASIRYSPAFDGDYVYFVNDDNKLYCCDARLGNSLWVYQAQEKIICQPLVAKDKIFLCTQPGKILSIDRSTGQKTWQYATQNTISHSAPTIEGKTMYIGDDGGNLYSLKFD
>NZ_AP019860.1|WP_151966454.1|780393_782091_-|protein-kinase
MKEASGRYHIKCEFARGGMGVIYEIFEKSLRRHLAMKVLSPPENVPVHKRDRDYFFEEALITAQLEHPNIVPVHDMGMLNDGHPYFTMKMVHGEPLCDIIEKLKKGDKQYIEKYPLVKRLIIFRKVCDAVAFAHSCHVIHRDIKPDNIMVGEYGEVLLMDWGIAKYTQADADTPLESRRIQSLRSKQDFSQTSYDEILGTPLYISPEQLDDDTSQVDHQSDIYLLGGTLYELLTFSPPHQGESLAQVLESSMLGRVVPPQKMNPMQQIPTELQKITMKALAHKKEHRYQKVEDLCADLDDFTAGSIVSEPVIFKEGEVLIRQDEKGTEAYFILKGKVDVIQTRADQEYLLATVEAGNIVGEMAVISEQVRMASVVAATDTQVLIINHQRMEEVLQKLPPWVGKLIFNLVDRLQTTDKNAHPLLLGDSLYHVLHQFTYILLSQMAFQIKTEEIEFNINTLTKQIAANLCMRQQKVQTALKYLATSSICQKINSETFKINDFSLFAYFLHFVHKMKKLDIAFPIPQLPEAGEETKTQALQLAQEATDYLSTKHKFTLRRKRDDVLRP
>NZ_AP019860.1|WP_151966455.1|782123_783314_-|GTP-binding-protein
MSGKLPVTILSGFLGAGKTTLLNHILTNQQGKKVAVIVNDVAKVNIDAEILKNNQVQVNNEESFVEISNGCICCSVRADLLAQVRDLSAQNKFDYLLIESTGVSEPLPVAATFAYEDENGFSLEQIAKLDTMVTVVDASNLAENFYNVEMLKNVDKSVAAGDQRTIVDLMVEQIEFANIILLNKVDEINEEQHQQAMQILRMLNAKAKIIPTNYSKIDINEIIGTGLFSFEEAATFSLWMQEKKKLKGHKVETAKYNIKSTVFRTPYPFHPQKLYSFLQNTSLGIVRAKGFFWLATQPDIVAELSQAGKRIAAQPIATWWAAQPKEDWPRDENWLAKLKESWHEVFGDRHQELVLIGVGLDTQKVEECLEECVIKDTKMNIEEWQKLKDPFNWEIY
>NZ_AP019860.1|WP_151966456.1|783325_785167_-|hypothetical-protein
MRFFHFCLLFCFSLFAYSDNSYVVNNEALGIQTILPGDDWSVLHQKSPQSQLAIYTSIEQKARFVLMSFPPQTYANMQQRATDIEKNAANYQQIQLQDTEINNVKAQRLIYKLYNSHVIEIGIPQIHAYTIVQLTTNVAAWQTPQQQQGWKNVFLRLRANTPQVFFRNLKNTSLQQIQTPKNITVTHHQVKIFVKNAYIDIENQVVLQARKNVAKLSLYVALGKISQVHFTRRSHRCDWKVIASKYPGLGKLIITNAKWDAQKRLHLQVKARMPYKNPQGIAMCFPTTYTTKATYNYQIYPGKNLSVITRKYFSPAKVIEFRQKVLRYSPQRFCLFIGKKYLSKKLSSSNHLIVVNGNKATVDRIHQQILFLQKLWKKTIKSDVIVIVNSDFSHDNFLSLATEDDVEKLSFVSQLAKLFVPHLAANLRLAVTSYLSALYIKSKKNKIGYFHHLDKKMASYRKIDIPTEYALADPLSITHPQIIATKAPVVFDMLRVYLGNKKFFRLWHTIVHTQKYRNYTQLIRALPQYKTFTDQWLLRAGYPQFVVSWSQSKAQVIVDIYQQMRKNPFVLSGKIYIVCREKTYTMPVKITQSHHKWFIVSEEEVERVYFRYY
>NZ_AP019860.1|WP_151966457.1|785420_787433_+|hypothetical-protein
MPYTVKDFEQDLLSKPSRVKPVLLFCKQLMGKNMQKFAAGKSATEFANVVILVLDTNVPQQTAKFLAYNLYPHVKGNSQPILKSIGKWEKEKNTRKVVKSLCSVLQKSRLSLTQKNSVPKKKGFWGNRIATISASKKVIGNRVKTIMQSGPRAMKNLFREETFTSASAPIKKNKTILGTNSPLKDKELEDLRVETLVSFNKQKPHAWVAIPNERELLRARPVDVFKILRSISLMINLTREQKKFVNFLKNTLMIRSKLLWEDEIIINIINQGMRSYNHTLDRLSKICTKRNVNRKIRDYLHCCTEIRLKKHGNLFRKQFDRVANIQSLDKLLDSYTLQSSTVVRKYKDLAIISNVKNLLRAYNRNPQKLDVLMNKHLGKHGETNIKSKLRTLLVTSGSDMEIFRKIQREKNIQGCINVLRRSSGDATVSKLLGLIDSFMRPENRTTFGGFKASLNFVCPALASRVEALMKSHVVLELNRETKTLLNSKEAAITRLNSLTKLLMMPKYQQANISIFETSPRSVADKIKVIKGSNSQQLKRNIEHSFPSPEFPKSLRNLVTQAKQDQSSRGEKNVDNFYRALQDIENRVKRRELTLIKNEVINLFKSYGNINFSGTKSQQFLNGYAIARVIEDYYRNPKRDKIDLSVDINPRVRSKVKAMIDSERQRQLQKL
>NZ_AP019860.1|WP_151966458.1|787443_788838_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MHQAQAFIAMPFDQKFYTVYKTIRAACESLNIKVIRIDEVWAREDIYKQIEEEILNSDFVITDFTGDRMLEVPNPNVVHEAAFARTKKKYLILMAQDHKCLPFDWRTRPAIIYQMTPEGLSYLEERLVLGIKALMEKDDFGRDYEEAAAHSFVTGYPPQMPQYMPVGYAPTTMNYVPPSNNTSLSEIEAHLISKQAQPVAVNSNHSSRLPKGFNKKKDRFVCRIDSSEMIHIPATEFTMGFEDEEPEHQVVLSEYLIDKYPVTNQQFAKFMESGGYQFQGFWSEAGWQWRVNNSILQPAFWNDEKFNSPDYPVVGVSWYEAMAYAAWAGKHLPTEAQWELAAKGSGTNQFPWGDEEPCNKKANYRSQFKQLTPVQQFEDAPSEYGCIDMAGNAWEWCYDWYDDDYYENSPRENPLGPGYSSDEEKVCRGGAWTYDVDTLKVYYRFFGIITLRDKSSGFRCARIL
>NZ_AP019860.1|WP_151966459.1|788847_792117_+|protein-kinase
MDNFSIAKQFPQWNFHEQIGDNYLLTTYIAENSKHGKCVLKLFSKTLLRDSEQTKTFFEQLDTTIRISHINLAKVHQTSISEEGTYLFREFLEGESLESQLQKRTFTPIEATQMILDIAQGIFSGYPFGIVYNNIKPSNIIVDDAGVAKLCDYCLPAIELAYLSPEQIKKQEVSSKSDVYSLNIIYYEMVRKRFLFHGKTIKDIIELQSRTAIPPQLKNFKNWPKGLPTSIRDIICKNLNRDPQERDTPFHFVKQLNGILKSLKVPRRNTIKIQKQTVTRRVKRPSTDKNVWGEVGLENNVESQVLADESVTDAENIVFSEEKLEKYIQEEIDSALTKFRTDKNEILPCLKFYFPKKYEETIVGYLLDLFHEECWLIKDTDKMSYLEIEIDLEKGCIQKHYYKFENILETAISKAYEAYDGKDEDEDEDENDNNEDKSQENNEPTKGNHDKTIDSEDLYKTIDVDSNEFVLPEVNEDISVSEKDGVTKIVTEKGSVEIDSKDLSGSLDGYDLEGEHIETLNDITVDSLTSVKNSIKSLSFTRQSLMVSRQLIGKKVQITVDFDNRHEATAWVKFVRKYKLYKGKQFIVEDEDVDVEVEPETERQTFTIFIDRLKAYEKVSEHIDRIKEFFEGDYEISEMDRGGMGAILKLISKHDSTILSLRPENYWARYKFAEYLKSLRNLKGEEVFYAELPKGTEFVIKVGFEGYEESLIQEAKILTSLAENENICNTIIGCVQQGRLFARDEKEDQEKIGYYLMLEYAHQGNLEQIYKSCPDNRLSPSIAFAIMYGMIQSLKILSDKGIIHRDIKPQNILLDNNGIPKLTDFGLAITTNQASSKLTDDRKRLLRIVDEKFCKISIQREHMQTILQNLIRTQENSEAIDLVLQEKIEILSEAIEKLKKQEEHRAEELKERYRPISAEENALKGRFAGSLYYAAPEQFTTDVVLTTACDMYQLGMVIFTMLTGKKPVSGRNTFDIMSKILDPNKPRVKDHIESSPIVDILSELIEKMIQHQPQDRIGVEDVRKTMSEVLFGYALELKKEPIFTPKLKLNEKQQERWDKKVEYAKKLHKTCIDAIFSTVFQDRGLPELQ
>NZ_AP019860.1|WP_151966460.1|792128_792830_+|hypothetical-protein
MLDEIIHYFAIWNIIEPCIFIFVIFIFFRDPIRRWNFFGYRPTAVTGIFDPKLEKVIFSKVNGFWSFNQGGIYEDNMYTTVADILNREVGLPQTRFKLIYFTSLGKVRLHNKRLLTRARISAFSIRSKLRGKGYMGCYIRCNLEGIESVIKKGAGIEEVRVVSFAEAKKLTDERCDHEEHQEKKRNMIIAMIEEMEGFARDEKKWRETQSIEEKSEEKASKEAQPENNEENGE
>NZ_AP019860.1|WP_151966461.1|792829_793954_+|glycosyltransferase
MDIAFCLFKYFPFGGLQSDFLSIAKKCREKGHLIDVYTRSWQGEIPDGFSVHLMKTNAITNVGKDVAYAKKLQKKLSTQQKLIVGFNKVPGLHVYFASDSCYARKVQHKSSWKKSFLPRNYHKLDLEASLFHSPQAHVMFIAPQQLKDFQEFYDVKPQYTHLLPPGINPQLKEYKRDNSYREKLLAHLQLAKDTFVILMVGSGFHTKGVDRSIRAIHSLKDNKAHLIIAGKGKETYFANMAKKLGVEKQVTFLGARSDIHELYLGSDMLLHPSYTESAGKVLLEATILGLPVITTANCGYAFYINKAKNGIVVPAPFRQENLNDALQKMRTTSNLYQVWGENGWNYGRENDLYSQHDRAVDIIEDVGRSLNLKM
>NZ_AP019860.1|WP_151966462.1|793988_796172_+|tetratricopeptide-repeat-protein
MDPNFFDQSNDLDPSFLKGIGSQDTAPTKEFTMPSTSKFDRYMIEKELGRGGMGVVYKAYDTKLRRTVALKVILNSNIGDVKRFRLESEAMAQLHHPHIVRIYDFGEAPQLHFTMEYIDGVTLADLIDEQKIKPLFLINLMMKICDALASAHKHKILHRDIKPSNIMITRSGEPKLMDFGLAKIYDNAQQSLSKSNDIMGTLLYMAPEQMMGKATEKSDIYSIGATLYEALTYRNIYDGRYSHEILLQMATHRPTPPRQVNPQISPYLEAVCLKCLEKKQINRYKNCQQLVREFKNLKSNKPILAKKYTYQDTIKNFISEHRILVASTLAIIISLCVSLAVVVKYSFDIKREKIRAEQGENKARQATAAIKKEKERTKLALNKVMNILEYSVKNHSHVFRQDKNFAKLVSEVFGSVGKYGENEEWGAIKGFIAQMSGNLQQSLEYYNEQVANATSDPIVYYNRGRIFEELKKYKQAMADYDTALQLSPKYVDVYHAKATIYDIWQKYESALREYRKIMVINPDYMPAYFNSASTYEKLGNISQAFVNYNKALQLAPDHSQIYYQRGNLYSKCKNYKLALVDYSNAVRTGPDNAIYYYNRGSIYEILQDDKHAVLDYNKALQLNPNYVNAYFNRGNIHRKHKNHLQALRDYNKVVQYAPQDFEAYCNRGTIYFALQKYREAINDFHKSLAISPKYWQAHHNLYSCYKAVNENAKAQYHLQKSRLLRVK
>NZ_AP019860.1|WP_151966463.1|796359_797517_-|DJ-1/PfpI-family-protein
MKLLLTVLLCLTCICAERDKVLVIVSSSDHITLADDSKHKTGFFLSELTIPVMALMKANYEIVFANPQGNKPVMDAVGDDVQHFSSKEEYQKAKELIQLSHFVAPVKLSTISDEQLHEFVGVFFPGGHAPMEDLCRDAQVGRVLRHFHKQQKPTALICHGPIALLAAKDENGWIYKDYNMTIFSNDEEKFAEENILHGKMKEFPAEALKKAGGKLSHAKPWTSHAVRDRELITGQNPKSDHQLTHLFIEALAKQKVSKKPLVAWNEKEPMKNNVLYNASLGTPDWSADAHIVLYVGRKKGDENFLQRLHAHVKMGRGAFVDSGCEGYVVYATEDTEIAYLWWKDVDSMYKVFSSDKGKACIADAKSFLEDVVFMPVTQKPVWLNQ

Crispr_ID: NZ_AP019860_4

• CRISPR_ID: NZ_AP019860_4
• CRISPR_location: 1154998-1155081
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_4

Consensus_repeat	Method
GAAATATATCAAAGACGAAAAACT	CRISPRCasFinder

spacers of NZ_AP019860_4

>4.1|1155022|36|NZ_AP019860|CRISPRCasFinder
GTGGAAGCAATTTGTAGAAAAAATCAAAGCAAACCC

CRISPR arrays and Neighbor proteins around NZ_AP019860_4

CRISPR arrays

The CRISPR arrays of NZ_AP019860_4

>merge|NZ_AP019860|4|1154998-1155081|CRISPRCasFinder
GAAATATATCAAAGACGAAAAACTGTGGAAGCAATTTGTAGAAAAAATCAAAGCAAACCCTGAAATTATCAAAGACGAAAAACT

>NZ_AP019860|4|4|1154998-1155081|CRISPRCasFinder
GAAATATATCAAAGACGAAAAACT	GTGGAAGCAATTTGTAGAAAAAATCAAAGCAAACCC
TGAAATTATCAAAGACGAAAAACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151966712.1|1164113_1165217_-|hypothetical-protein	unknown	unknown	gnl|CDD|259802
NZ_AP019860.1|WP_151966710.1|1161022_1162156_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_AP019860.1|WP_151966709.1|1160251_1161010_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224045
NZ_AP019860.1|WP_151966705.1|1151033_1152662_-|L-glutamate-gamma-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|143441
NZ_AP019860.1|WP_151966704.1|1148710_1150882_-|dynamin-family-protein	unknown	unknown	gnl|CDD|206739
NZ_AP019860.1|WP_151966700.1|1144647_1144962_-|ATP-dependent-Clp-protease-adaptor-ClpS	unknown	unknown	gnl|CDD|225038
NZ_AP019860.1|WP_151966708.1|1159428_1160247_-|metal-ABC-transporter-permease	unknown	unknown	gnl|CDD|224033
NZ_AP019860.1|WP_151966713.1|1165216_1166497_-|hypothetical-protein	unknown	unknown	gnl|CDD|259803
NZ_AP019860.1|WP_173013124.1|1166507_1168061_-|protease-modulator-HflK	unknown	unknown	gnl|CDD|259802
NZ_AP019860.1|WP_173013122.1|1145603_1146140_-|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511
NZ_AP019860.1|WP_151966698.1|1142033_1143398_-|hypothetical-protein	unknown	unknown	gnl|CDD|176037
NZ_AP019860.1|WP_151966703.1|1147959_1148553_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966707.1|1157122_1159336_+|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|222980
NZ_AP019860.1|WP_151966706.1|1152769_1154428_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|379311
NZ_AP019860.1|WP_173013123.1|1146304_1147777_+|glutamate-formimidoyltransferase	unknown	unknown	gnl|CDD|226169
NZ_AP019860.1|WP_151966701.1|1144988_1145591_-|type-II-secretion-system-protein-GspG	unknown	unknown	gnl|CDD|377975
NZ_AP019860.1|WP_151966699.1|1143440_1144625_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966715.1|1168042_1168423_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_152021957.1|1155211_1156987_+|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl|CDD|273520
NZ_AP019860.1|WP_151966711.1|1162228_1164112_-|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|225127

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151966712.1|1164113_1165217_-|hypothetical-protein	gnl|CDD|259802	cd03404, SPFH_HflK, High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prokaryotic HflK (High frequency of lysogenization K). Although many members of the SPFH (or band 7) superfamily are lipid raft associated, prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this SPFH domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflK is an integral membrane protein which may localize to the plasma membrane. HflK associates with another SPFH superfamily member (HflC) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.	2.21418e-41
NZ_AP019860.1|WP_151966710.1|1161022_1162156_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.40322e-91
NZ_AP019860.1|WP_151966709.1|1160251_1161010_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.2723e-65
NZ_AP019860.1|WP_151966705.1|1151033_1152662_-|L-glutamate-gamma-semialdehyde-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0
NZ_AP019860.1|WP_151966704.1|1148710_1150882_-|dynamin-family-protein	gnl|CDD|206739	cd09912, DLP_2, Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins. The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.	6.20577e-17
NZ_AP019860.1|WP_151966700.1|1144647_1144962_-|ATP-dependent-Clp-protease-adaptor-ClpS	gnl|CDD|225038	COG2127, COG2127, Uncharacterized conserved protein [Function unknown].	1.27726e-32
NZ_AP019860.1|WP_151966708.1|1159428_1160247_-|metal-ABC-transporter-permease	gnl|CDD|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	1.46043e-23
NZ_AP019860.1|WP_151966713.1|1165216_1166497_-|hypothetical-protein	gnl|CDD|259803	cd03405, SPFH_HflC, High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prokaryotic HflC (High frequency of lysogenization C). Although many members of the SPFH (or band 7) superfamily are lipid raft associated, prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this SPFH domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflC is an integral membrane protein which may localize to the plasma membrane. HflC associates with another SPFH superfamily member (HflK) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.	3.5278e-64
NZ_AP019860.1|WP_173013124.1|1166507_1168061_-|protease-modulator-HflK	gnl|CDD|259802	cd03404, SPFH_HflK, High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model characterizes proteins similar to prokaryotic HflK (High frequency of lysogenization K). Although many members of the SPFH (or band 7) superfamily are lipid raft associated, prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this SPFH domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflK is an integral membrane protein which may localize to the plasma membrane. HflK associates with another SPFH superfamily member (HflC) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection.	1.96787e-51
NZ_AP019860.1|WP_173013122.1|1145603_1146140_-|RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	6.83984e-47
NZ_AP019860.1|WP_151966698.1|1142033_1143398_-|hypothetical-protein	gnl|CDD|176037	cd08391, C2A_C2C_Synaptotagmin_like, C2 domain first and third repeat in Synaptotagmin-like proteins. Synaptotagmin is a membrane-trafficking protein characterized by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains. Previously all synaptotagmins were thought to be calcium sensors in the regulation of neurotransmitter release and hormone secretion, but it has been shown that not all of them bind calcium. Of the 17 identified synaptotagmins only 8 bind calcium (1-3, 5-7, 9, 10). The function of the two C2 domains that bind calcium are: regulating the fusion step of synaptic vesicle exocytosis (C2A) and binding to phosphatidyl-inositol-3,4,5-triphosphate (PIP3) in the absence of calcium ions and to phosphatidylinositol bisphosphate (PIP2) in their presence (C2B). C2B also regulates also the recycling step of synaptic vesicles. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains either the first or third repeat in Synaptotagmin-like proteins with a type-I topology.	1.26146e-09
NZ_AP019860.1|WP_152021957.1|1155211_1156987_+|ATP-dependent-zinc-metalloprotease-FtsH	gnl|CDD|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_AP019860.1|WP_151966706.1|1152769_1154428_+|HEAT-repeat-domain-containing-protein	gnl|CDD|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	2.72067e-12
NZ_AP019860.1|WP_173013123.1|1146304_1147777_+|glutamate-formimidoyltransferase	gnl|CDD|226169	COG3643, COG3643, Glutamate formiminotransferase [Amino acid transport and metabolism].	1.41271e-117
NZ_AP019860.1|WP_151966701.1|1144988_1145591_-|type-II-secretion-system-protein-GspG	gnl|CDD|377975	pfam08334, T2SSG, Type II secretion system (T2SS), protein G. The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. The T2SG family includes proteins such as EpsG (P45773) in Vibrio cholera, XcpT also called PddA (Q00514) in Pseudomonas aeruginosa or PulG (P15746)in Klebsiella pneumoniae. The PulG is thought to be anchored in the inner membrane with its C-terminus directed towards the periplasme. Together with other members of the Type II secretion machinery, it is thought to assemble into a pilus-like structure that may function as a dynamic mechanism to push secreted proteins out of the cell. The polypeptide is organized into a long N-terminal alpha-helix followed by a loop region that separates it from a C-terminal anti-parallel beta-sheet.	4.82913e-09
NZ_AP019860.1|WP_151966699.1|1143440_1144625_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.28586e-85
NZ_AP019860.1|WP_151966707.1|1157122_1159336_+|ankyrin-repeat-domain-containing-protein	gnl|CDD|222980	PHA03095, PHA03095, ankyrin-like protein; Provisional.	1.56386e-27
NZ_AP019860.1|WP_151966711.1|1162228_1164112_-|heavy-metal-translocating-P-type-ATPase	gnl|CDD|225127	COG2217, ZntA, Cation transport ATPase [Inorganic ion transport and metabolism].	0

Protein sequences

>NZ_AP019860.1|WP_151966706.1|1152769_1154428_+|HEAT-repeat-domain-containing-protein
MSETKTLRSVLGEQVNIPKSYTRYLDCSVVSQQQKNIFIKTPKGNTLIFKVEGNSLKKLTATSHMDIQNSEDNNTINKGINTSTPASASVSKDVNDLQKQMESVKDVNKAIPDLQKRIEALEKIPQQDIVFISSNEWKSVQEQLQKNSEYQQKNSEYQQQNNEYQNQNSEYQQKITALEERLLKLEEKLSLLESSSSKSETMQKVARGSAKAAVVGSKFLWQHPRVFAGIVAALFLMIWQPWSYFGGTGNENPNGYTGQNLGKRNTNYIIKKNSSSTSNNTSSRKSQHHKTEDDGNYLSPQDRRYAKEIKEDNSSQLRDWVRKLKGLPPKERENEIRSMGSSTDPMTGKVLIAMLADPQVTWVAVNTLGEKRYRQAVPFLVEVLEDKNREDYVRAETCTSLGILGNPFTAKLLKKVFMDTQENEDVRLNAGLALGVIGDANVSPDLLEVVFNSQNPAIRQAAITTLGKFQYPAAITPITDVMNATEDIDLKRACIDALGQMRRKANDVAPTLVNMLEKGDPDLEDNLKASLRNLLSRLKPELQKRVSEMIQE
>NZ_AP019860.1|WP_151966705.1|1151033_1152662_-|L-glutamate-gamma-semialdehyde-dehydrogenase
MLFGNFNIPQPYNEPVKNYAPGSQERASLQKKYQELKQEKIEIPMVIDNTAHHSQDIREVRCPHDHQHVLATFHHASTQDAQKAIDSCLNARKKWSTTPFHHRASIFLKAAELISTKYRDVLNAATMLGQSKTCHQAEIDAACEFIDFLRFNVKYAEQIYQDQPISSQGIWNCLEYRPLEGFVLAITPFNFTAIAGNLCIAPAMMGNVILWKPSPKSIFSSHFLMQILQEAGLPKGVINMLPADGAEFVQEVIKSRHLSGIHFTGSTSVFRAIWKAVGNNIDLYDSYPRIVGETGGKDFMFVHKSANVQAVATAMIRGAFEFQGQKCSAASRAYIPQSMWSQLKDILTAEVPTIKVGDVEDFSNFMGAVIDDLSYQKISGYIDRAKKAEDCEVLVGGNCDNSKGYFVEPTILVTQNPQYETMVQEIFGPVLTVYVYADDKYEETLELCGSTSEYGLTGGIFASDIYAVETAYENLRDSAGNFYINDKVTGAVVGQQPFGGGRGSGTNDKAGSYLNLIRWVSPRSIKQAFCPPTDYRYPFLGN
>NZ_AP019860.1|WP_151966704.1|1148710_1150882_-|dynamin-family-protein
MVDSSPEVGKMFDEFNESRQALSSQFYGLIDLVANHVFSGNVNIQDKKNLLHQINNQQNLVEAEKNLLRNLYFYANNLQESQFLLGVFGRFKAGKSTLLNTLAGEYISPMNTRISTGVLNFTYSSEIEECTVHYDNGTKEVIEPALKDEYIDFRHNPDNEKGIHSVRHGCPNLALQKEIVFVDTPGLEAVNSVHEKITLDFVMQCHVAVVVSTYPPFGEGELRFYKRIHKNIPNTFLVQNLPKDKLESWIPLEAQTLENLHKLGFYEINKEVYGEEDHCEILRTIGDNKDEQQLLKFKKAHDIHLYSLCALTAHDILNGAGKNNLSADEQQRLDDSRFMLFKKDLYGFLTSHRGQSMLADYLLKGQLILNSLVKMVKDRQTLLQQSLEEIERNIAAEEQQQQKTIQLTEMIADRASLKILELYRELKSAVMNDDINQALGEVKQKYAEKNIYRLSKRQLKEIKSQVSAFNRLFGQRYQGFVGELEKITETAQSEISEQLQNQAVFKNIVLDTNAGAVNVGEISGAGYLDRTFDFIFHGGITYIVASICGGSGWSILEPFVKPAVGVNSASLVALSIGGIIGLAASIPLAKHFAPFLDKCKGFIGKFYTKPAKVVFDEFEGNVRKKLDEVETTAVDNLKKSFKEQASAGINQFFEMVNKTLKELREQKENGNETQENEKLCNILAQLSQIQQQFSVMEKKDDVSQQKVQKVLTGFKGLFGKLKK
>NZ_AP019860.1|WP_151966703.1|1147959_1148553_-|hypothetical-protein
MVSRFIIILSAILPLVGCIGGIRDTTTARTATEILLVSTAAERAIKNYKVDKSLSGKKITIDDSRYDAVDKPYVSSALREHLSAAGAIVVADGSDYTVEVRNGTLGIFDSDFTLGIPGLPVALGGIGAELPPVITPPLSVFRRDTSQGWCKMQLWIYKTEDNTFVSKSGDLWGSSYYNQWIFLFIGPFDGSNDIYPD
>NZ_AP019860.1|WP_173013123.1|1146304_1147777_+|glutamate-formimidoyltransferase
MKLIECVPNFSEGRNREIIEQIVSSIASVDGIYVLHYDMDADHNRTVVTFLGTPENIVESAFRGIARAKDLINLNEHCGEHPRLGVTDVCPFIPYKNVTMEECVDCAQQLAKKVHEELQIPVYLYEEAAVKPQHKNLADIRLKQKTLTPDFGVEPHPTAGYVCIAARFFLIAYNINLQTQDVTIAKKIAKAIREKNDGLKAVKALAFVLQERNCVQVSTNLIDYRQTSLLKIFHEVERQANAYGVQILDSEIVGLIPQDALRSGIVEELKLYHFVNDKVIEHRLQSLESYHLNVFLEKLSLATPSPGGGSCAALTGATAAALAAMITGISMRKRKNRDHLEFLLEKRNELQKLQRHLAKLIEEDAGVYQEYLNAKKMPRKTAEEKKKHEEAVDSALIRCILVPLDIAVTSLGVLKLLPISYLSKTTMSDAGIVASQISSAIEGSILTIRGNLSFTKDEDVVAQIRKDIQEIEKQRHELASKIMCEVEKFL
>NZ_AP019860.1|WP_173013122.1|1145603_1146140_-|RNA-polymerase-sigma-factor
MQSEEDLIHSFIGGNDDAFRQLVEKYQGPLLNYLYRFTGKYEVAEEIVQDTFLVVFQKIDSFKKNSSFRAWLYAIATNHASNYLRKHAPVYNNEALNMASNVLFEPSEKTIEKERALAVQQALKTLPEKQRAIFILRFYQQFTYEEIADTLKCPIGTVKSRICYTLQKLKGILSSHEE
>NZ_AP019860.1|WP_151966701.1|1144988_1145591_-|type-II-secretion-system-protein-GspG
MECNKIKDILDAYILGALENEENNKVKQHIQHCTECKKYHDESVRSWQKLQNLPTVSPSVSYADRIIKNHRRGKRIMQWTISTVFILLVMVLFLLFLLFFLFEYKKEYPQHHIANLEKIVWRFYSENKTFPNTLRDIPEKLFPKKMLFQRDDNGQVLDMWGRPYEYHVPGKHNKGFFDLYSFGRNGKNDNGSKDDIRNWK
>NZ_AP019860.1|WP_151966700.1|1144647_1144962_-|ATP-dependent-Clp-protease-adaptor-ClpS
MDKHELDDIVITQKKEKLQRPKMYRVYLHNDDYTLQEFVEFVLQEVFFKSYEEARKIMLEAHMKGISIVGIYTYEVANDGIQQVEIYAEKLGYPLLCTMEEIDI
>NZ_AP019860.1|WP_151966699.1|1143440_1144625_-|protein-kinase
MTKNILIIDYESEDYPQEMFKGYRVYNVSTMMDAVKRILLQRPHVIVANIDIYENDASILTHILKVNKNTPIVAITSDKKNVKIVRKNLPKQVYALFCKPVSMLNLVNAVNSAPQSIVTKDEHKSNQAVGKKIDNYVVKKTLGCGASGTVYKASDGTTEVAIKILKAQFNNDMKRFNRETKYLMAVDHPNIVKAMYARQLDDEYYYIVMELFEAEHLSRHLARQGFFSLEESTFLIREIAKGMAAAHKVQLIHRDLKPSNVLYNRHEKKIKIIDFGIAKRPEDFSLTTEGIALGTPAYMSPEQIITPEIDHRSDIYSLGIIFYNLLMGDPPFDGEDDHEVMRAQMYEEVSWPVAEKQVPQYIRDVIEKMLHKNREHRYQTMEEVDEALANVTSN
>NZ_AP019860.1|WP_151966698.1|1142033_1143398_-|hypothetical-protein
MRFFVIIILSVFVYANDTQWVTKDFAHFSFKVQASWKNSSANMYQINNSNYVDFRHYPVTSNIEEEIAKIENILFAQQVYSKVQQKSHMVNHASGTAITYKTATQFYDVFFCIFEDKLYVVLYCFSDKLYAQMLQNSAQSFTVKKVNPSTVEEYHKNFAVKYSIDPKWQKEVLTNTVDKKTIFYRISPFFSMQVYMEILPFEVPLHLTIEKIQRIFFPHHVYARVIKKPQTSVPGKQYFYIIRDKSFPLRYRYAEIFFCIRGRRAYAVAYFYQKKSVHLEDILKSLVIENKFSYTDRKQDTTTETNDNNPDENSEPSETEKPREEDVPKITKSYLIHVTSAKIFIQKTNGKKWDFGWGKTTAPDSYATIKEFGSEKEYTTSIVRNSLQPKWNYATPIVAKKGQVLVINVYDDDSRKNDEIGTIMITIKESDIKKGFRDIQFNSVEKLTLTFMAK
>NZ_AP019860.1|WP_152021957.1|1155211_1156987_+|ATP-dependent-zinc-metalloprotease-FtsH
MENYWGAMFFTWGLPIILIIIFFIILMRRMNSYGRDVMSFGKSRAKITAEEDTKTTFEEVAGCDEAKEELSEIVAFLKSPGKFEELGGKIPKGALLVGPPGTGKTLLARAVAGEAGVPFFNISGSEFVEMFVGVGASRVRDLFAQAKAKSPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLAEMDGFESSKGIIILAATNRPDILDPALLRPGRFDRQVVIDQPDVRGREQILKIHSKGKPLADEVDLKTLARRTPGFSGADLANVMNEAALLAARKDKTEIQQSDIAEAVERVMAGPERRSRLISDKEKENTAVHECGHGIIAVLHPDSYSAVHKITIIPRGRALGYVLQMPNEDKLSQSKEELLANICMALGGRVAEEIVYNRLTTGAANDLQQITNIARSMVAKYGMSEEMGPIAYEKDSGHVFLGKSQNERNSYFSEATLNKIDAEVQKLVNNCYQKAKDILTENRQILDTATKILLKRESLEGAEFSEIVHKIKNGENVDAYFEEPANSSAKEKVAEAEKAKAEAEKAKAEAEKAKAEAEKAKAEAEKAKAEAEAQKAEVEAGTEAEAEKTEENTTEKDDNE
>NZ_AP019860.1|WP_151966707.1|1157122_1159336_+|ankyrin-repeat-domain-containing-protein
MKKILLLCVCVTLNMVMANDDFLKAAKEGNIAAMKEMIKAGVDVNYSSKKSSGYTAMSYSLRDGNLEAVQLLIDSGADVNMRYSYGLRTYSFALHYASSGKSKVENTNKIIEALVKAGLKLEADAGGDSFLFTSISFISDNDKCIAVVEKLLELGNDVNAKDNRSNTAMMKIVSEDEDKALRLLEVFVAKKADINAVNKDKNSALSLAVYKKKKQIVKFLLENGADVNQGYSTYSGTTTLLAKAIDNTDTETMDLLFAHKADLSADKGREALKAAIGCARYDKDNIPACQKMLKILVEKGKVDINSLDKDGETVLFELTGEDAELQEAAVETLVSLGIDLNKKNNKGKTALLASVDHYNNEKALNLVKLLLKNKADGNAVDKEGNTLLLSACSSYSDRKVDFVSYLVKNGADVNKVNNKGQTALHVALDKDSPKTVQLLIDAGASPDVEGAESLLFNTKMDLKLYKSLVEKSSNINAQNKKGQTPLIAALEYIKYTPKLADYATALIEKGADVNVADKKGNTALSYACQAGNVAFAKLLIEKNANVNVSDAENNSLVIQAADGESLELVKLLVEKGADVNAKNKYGGSALSEAGGNNDLPMIKYLVEKGADVEVVDGYGRTPLIHAARKNNAETVAFLLENGVKKLDVAGMGGKTALHYAAYEESVKNISLLLEKGANPNIQDDYGNTALHLAIYAKKEELVKPFLKANVDLTLKNKKGQTVVDIAKGKILELLQSK
>NZ_AP019860.1|WP_151966708.1|1159428_1160247_-|metal-ABC-transporter-permease
MLQEFITSFPLFFETYLSALFMAIFLSIIGILVVNREQIFLTAAISQAATLGLAIDILLNLQQPMICAVVLSILAAVVSGRKDKRGGSNREEFSAWVFLVSASLSVLLLSNHPQGIKQIQASVASSIIGSGIFEVVVFAIISVFVAAVCLIFNDKLRLFVMDPIMAAAVGIPIVLWGWYISLFLGFSIGMAMCSSGMLYTFGCVVLPAQIAKTLCQRLSYMFIVSPIVAVISVVCGLIFANHYNYPPGQMVIALMGMILVVSWMIQWLRTKA
>NZ_AP019860.1|WP_151966709.1|1160251_1161010_-|ATP-binding-cassette-domain-containing-protein
MEKEQAQQETPIIVAEKANIGYGKKVILQDVNMEIHSGDFWCFIGSNGSGKTSLIKSILGAIKTLRGVVVLRKDFARRTRIGFVPQESELNKSVSTTLEEFVACGLAGIPFKKSVRHKRTLKVMEIMGIKHIKNSSIWNVSGGQRQRAMIARALIRDPLLMIVDEPTSGLDFRAAHELLQTITDLNRDKKITVIFVTHDLNICQELASHVAMFHDQKVIAGVKEEVFNSENLEKTFGIAVEFPFYRTLKSKE
>NZ_AP019860.1|WP_151966710.1|1161022_1162156_-|ATP-binding-cassette-domain-containing-protein
MSNAKKIVEVIKLHKVYKDFWGREKVRAVTNLNFDVRQGEIFGLLGPNGAGKTTTIKLLLGLLFPSHGKVTIFNQSPRSIFSKSRLGFLPEESYLYPYQNAEEALTFYAKLFNLPPKIRKKRVNDLIEMVGLEKARKRFIKEYSKGMARRIGIAQALINDPEFIILDEPTSGLDPLGTREIKDLILELKKHGKTILLCSHLLSDVEDVCDRFCILYSGHKICEGDIDTLLANEDMMQVTSEKMDADRQKRLASWFAKEGLEVYNFGNKRQRLETFFLQQIEKAREEHMEQQKSKRELKEFVSEAKKDTKGQENILEQLVKTNEPEEKPEPVVEEKAPEVKVEDLLKKEAPAPEQKQQQEPKKEVDQSLIESLTNKKK
>NZ_AP019860.1|WP_151966711.1|1162228_1164112_-|heavy-metal-translocating-P-type-ATPase
MAVAQHQHQQQQQRVMLRLFATFLGGALIINSFFLEMMFKTSAEIAALSAFFGAIVLGAPVIIQSIRSITTGQMKVTELASIAILSSVALEMYQTAGIVAFFMLVADALQTRTALGARDAIESLIRLAPNEATLISSGSEQRVVVSALKKGDIVRVRPGENIPADGIVVKGQSVVEQAKITGESLPVDKMIDSEVFAGTTNATGMLEIKVTKVGEDTTLGRVKQLILEAEKTKTPIMQIIDKHVSWYTPTIIMLAALILYFSQEIERAITALVVTCPSALVLATPTALVAAISCAARLGILIKDVKYLEEAAQLNSIVFDKTGTLTTGNLAVTRLSPAPEIEASNLLSLAASLEQYSNHPVAKAVVTMAKKANIELIDLPEVHETAGKGMSGYIEQKHILIGRESWLREEGCDFSKLLPEDMENAEYSVLYIAQNKECVGWIGLEDTTREEAFSTTKDLKSLGCKEITMLTGDRWPVARKVGKELGCTNVHAECLPETKQQLVEKIKQQGSRVAVVGDGVNDAPALAAGNIGIAMAAAQNDIAINSASIALLNDRLDRLPFLIKLARKTKLIINENLFFGIFFIIVGLTLSGFGLLTPIWGAILHNIGALVIVFNSARLVRFGEELM
>NZ_AP019860.1|WP_151966712.1|1164113_1165217_-|hypothetical-protein
MSQEPHSNSEELSYVNELADQSLAEALNLSFKILKGIMLLLIFIFIGSGVFIVNQHEVALVMRFGDIVGAQGAKEKQPGPHWTFPFPISKIIRVDKRDHSLTLEDFWYYEDPDVSEEKRRSRAKGNLDPEKDGYCLTSDANIVHVEKLQIRYKVDNAYDYVMFNKNPKQLLHNIILGATVKAVASFTVNEARQKTDEVIRFVRVNAQQRLNRARSGLQITALSLRIIPPLGVQDAFDSVIKAEAQKLKDLEMAIGYATRIKNEAEASAKEIINKANTFKSNIVQSAQSDVKYLQLIKNRFKNTPEIYQQTYYHQVLQEIAAEINELFILSSSAENRELRIRLNRDPELKKFSAPEGQEPDILEKEEN
>NZ_AP019860.1|WP_151966713.1|1165216_1166497_-|hypothetical-protein
MTNENKNENTQNKPNVVTIIVAIIIAVTLLFYFFTFQVRITEKAVVTTFGKPTKVIDPSTDSGAGLYWKWPYPFQKVNVFDARMRIFTGTLEQIFTSDSKSIILQTYTGWQIDDASKYQIRSVNESRAKSHLESFIRSHTYTVIAKYSFYQIISSSKGKSFLEDIEEKIRQKVNQDVIEFGFEVKEFGFRRLVLPESTTKEVANRMKEERNRLAEEYRSQGAKESKIKRNQADAFRQEKIIVAEARAKEIEGEAFAQIADEYKTFAKDKKLAIWLRKLESLRNILKANRSTLLLDPSTQPFDLLQNSSINSVFSENENINNTPENTNNSEEQNDESTATSENADTKASSTTDTSTEKNVDESTKDESTQEESAQEKPTETSENNNTDEKPVEESANSDKASATQDENQAKKDDTPDPSQEKTKENK
>NZ_AP019860.1|WP_173013124.1|1166507_1168061_-|protease-modulator-HflK
MAAYNLNDIIQGVRTTVKQAPLSAAFLGGFAFFSLLIAKYTLGMAQRKNLRILRAGGSYLFVNAATSFLCCVAVTMSHTGFENIDLYVAYGILTIMGLIGIEILFNLLLDFYRPRVSNEETRVPFDSRLLEISSGSKGVLNTIAQMFDYQFGFKVSETWFYQFMEKAIAPLLLFQIFSLYILNCIIFVGPSEQVIVERFGTLNRIYSPGFHVKWPWPVESAIHVDKEKVHNIIVGQFGDPELPLIEKYDEYGDKIHTARIFAKKHHADEDVFLVIGPQQGDQNLIVNLMVARASVVYVINDLKKYTYNHQNPEILIDSLANKVMTRFFASAEISELIGEKREATSIFLKKTLQKECEKKEVGVEILSCQLLEAHPPQYVARDFEDVISALEAKETKIMAAETYAAKVEKQVEASVAEILLKAKVRQLEKVKITTAKANMFDNTLKAYKESPEVFLLRQYLRTLEKNMKNRRLIISNVKNTKRQVDSLNLEDSGMKIVDYKIPVENEENDHDHGIEGN
>NZ_AP019860.1|WP_151966715.1|1168042_1168423_-|hypothetical-protein
MNDNVAMKKAENIAFFACFLQFLFFILTFSISYWESISIRTQSVFYMMGIAIWLLSYLSIRQERLAEEEEQAEKEYVTDNNNSIFDEADQLDPLSARNRLKTFQTWVIPIASFVIAVIFIFWRHIT

Crispr_ID: NZ_AP019860_5

• CRISPR_ID: NZ_AP019860_5
• CRISPR_location: 1448238-1448320
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_5

Consensus_repeat	Method
CACCAATACGGAAAAAGAATCCC	CRISPRCasFinder

spacers of NZ_AP019860_5

>5.1|1448261|37|NZ_AP019860|CRISPRCasFinder
TAATCGAAAGCGAACCCACACAAAACAATAGTGAGAA

CRISPR arrays and Neighbor proteins around NZ_AP019860_5

CRISPR arrays

The CRISPR arrays of NZ_AP019860_5

>merge|NZ_AP019860|5|1448238-1448320|CRISPRCasFinder
CACCAATACGGAAAAAGAATCCCTAATCGAAAGCGAACCCACACAAAACAATAGTGAGAACACCAATCCGGAAAAAGAATCCC

>NZ_AP019860|5|5|1448238-1448320|CRISPRCasFinder
CACCAATACGGAAAAAGAATCCC	TAATCGAAAGCGAACCCACACAAAACAATAGTGAGAA
CACCAATCCGGAAAAAGAATCCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151966899.1|1439386_1440481_+|type-II-secretion-system-F-family-protein	unknown	unknown	gnl|CDD|224376
NZ_AP019860.1|WP_151966912.1|1449455_1449833_-|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|224523
NZ_AP019860.1|WP_173013142.1|1448332_1448482_-|hypothetical-protein	unknown	unknown	gnl|CDD|378415
NZ_AP019860.1|WP_151966902.1|1442405_1443017_+|superoxide-dismutase	unknown	unknown	gnl|CDD|223678
NZ_AP019860.1|WP_151966914.1|1451087_1452434_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966905.1|1445260_1445782_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966919.1|1460762_1461311_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966906.1|1445974_1446631_+|hypothetical-protein	unknown	unknown	gnl|CDD|214854
NZ_AP019860.1|WP_151966916.1|1456377_1457832_+|hypothetical-protein	unknown	unknown	gnl|CDD|239649
NZ_AP019860.1|WP_151966917.1|1457837_1459091_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|274963
NZ_AP019860.1|WP_151966915.1|1452439_1456186_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013141.1|1446639_1447668_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_AP019860.1|WP_151966903.1|1443109_1444642_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143448
NZ_AP019860.1|WP_151966904.1|1444643_1445252_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013139.1|1440643_1441813_+|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NZ_AP019860.1|WP_151966913.1|1449822_1450941_-|aminopeptidase	unknown	unknown	gnl|CDD|225191
NZ_AP019860.1|WP_151966911.1|1448560_1449454_-|UbiA-family-prenyltransferase	unknown	unknown	gnl|CDD|376441
NZ_AP019860.1|WP_151966909.1|1447668_1447884_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966918.1|1459105_1460461_+|endonuclease-domain-containing-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013140.1|1441832_1442294_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|379311

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151966899.1|1439386_1440481_+|type-II-secretion-system-F-family-protein	gnl|CDD|224376	COG1459, PulF, Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion].	3.29008e-116
NZ_AP019860.1|WP_151966912.1|1449455_1449833_-|acyl-CoA-thioesterase	gnl|CDD|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	2.61764e-38
NZ_AP019860.1|WP_173013142.1|1448332_1448482_-|hypothetical-protein	gnl|CDD|378415	pfam10262, Rdx, Rdx family. This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium.	1.33664e-09
NZ_AP019860.1|WP_151966913.1|1449822_1450941_-|aminopeptidase	gnl|CDD|225191	COG2309, AmpS, Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism].	3.71373e-49
NZ_AP019860.1|WP_151966914.1|1451087_1452434_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.76074e-40
NZ_AP019860.1|WP_151966916.1|1456377_1457832_+|hypothetical-protein	gnl|CDD|239649	cd03677, MM_CoA_mutase_beta, Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta heterodimers. For P. shermanni MCM, it is known that only the alpha subunit binds coenzyme B12 and substrates. The role of the beta subunit is unclear. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The reaction proceeds via radical intermediates beginning with a substrate-induced homolytic cleavage of the Co-C bond of coenzyme B12 to produce cob(II)alamin and the deoxyadenosyl radical. MCM plays an important role in the conversion of propionyl-CoA to succinyl-CoA during the degradation of propionate for the Krebs cycle. Methylobacterium extorquens MCM participates in the glyoxylate regeneration pathway. In M. extorquens, MCM forms a complex with MeaB; MeaB may protect MCM from irreversible inactivation. In some bacteria, MCM is involved in the reverse metabolic reaction, the rearrangement of succinyl-CoA to methylmalonyl-CoA. Examples include P. shermanni MCM during propionic acid fermentation and Streptomyces MCM in polyketide biosynthesis.	2.00434e-106
NZ_AP019860.1|WP_151966917.1|1457837_1459091_+|AAA-family-ATPase	gnl|CDD|274963	TIGR04075, Ser/Thr_phosphatase_family_protein, polynucleotide kinase-phosphatase. Members of this protein family are the bacterial polynucleotide kinase-phosphatase (Pnkp) whose genes occur paired with genes for the 3' terminal RNA ribose 2'-O-methyltransferase Hen1. All members of the seed alignment belong to a cassette with the Hen1. The pair acts in bacterial RNA repair. This enzyme performs end-healing reactions on broken RNA, preparing from the RNA ligase to close the break. The working hypothesis is that the combination of Pnkp (RNA repair) and Hen1 (RNA modification) serves to first repair RNA damage from ribotoxins and then perform a modification that prevents the damage from recurring. [Transcription, RNA processing].	2.89407e-100
NZ_AP019860.1|WP_151966915.1|1452439_1456186_+|HEAT-repeat-domain-containing-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.44369e-55
NZ_AP019860.1|WP_173013141.1|1446639_1447668_+|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.32454e-26
NZ_AP019860.1|WP_151966903.1|1443109_1444642_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143448	cd07130, ALDH_F7_AASADH, NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B. Alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as ALDH7A1, Antiquitin-1, ALDH7B, or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), is a NAD+-dependent ALDH. Human ALDH7A1 is involved in the pipecolic acid pathway of lysine catabolism, catalyzing the oxidation of alpha-aminoadipic semialdehyde to alpha-aminoadipate. Arabidopsis thaliana ALDH7B4 appears to be an osmotic-stress-inducible ALDH gene encoding a turgor-responsive or stress-inducible ALDH. The Streptomyces clavuligerus P6CDH appears to be involved in cephamycin biosynthesis, catalyzing the second stage of the two-step conversion of lysine to alpha-aminoadipic acid. The ALDH7A1 enzyme and others in this group have been observed as tetramers, yet the bacterial P6CDH enzyme has been reported as a monomer.	0
NZ_AP019860.1|WP_151966906.1|1445974_1446631_+|hypothetical-protein	gnl|CDD|214854	smart00849, Lactamase_B, Metallo-beta-lactamase superfamily. Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.	4.49193e-10
NZ_AP019860.1|WP_173013139.1|1440643_1441813_+|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.15624e-25
NZ_AP019860.1|WP_151966902.1|1442405_1443017_+|superoxide-dismutase	gnl|CDD|223678	COG0605, SodA, Superoxide dismutase [Inorganic ion transport and metabolism].	6.18241e-101
NZ_AP019860.1|WP_151966911.1|1448560_1449454_-|UbiA-family-prenyltransferase	gnl|CDD|376441	pfam01040, UbiA, UbiA prenyltransferase family.	2.46985e-32
NZ_AP019860.1|WP_173013140.1|1441832_1442294_+|HEAT-repeat-domain-containing-protein	gnl|CDD|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	0.0076406

Protein sequences

>NZ_AP019860.1|WP_151966909.1|1447668_1447884_+|hypothetical-protein
MQHAKQPCDWEGEKRECPYILDDYKYSFWGWTLLSIGISAKPVRLIRTCSKCHEEIEDITDHKQLMEHIGR
>NZ_AP019860.1|WP_173013141.1|1446639_1447668_+|tetratricopeptide-repeat-protein
MFGFGKRKKKKEDEVKANEELNQDINIDDSEGDQVDEVDEDVSEVDDDVSEVDEDISDVDELDDIDEIDELDDDIDEIDDVDDDIEDVQDAKSENIASQKDFEEVSSPTIKPANISSSHNISTEDIKRSMEANNNGIRCKKNRDFAKALEMYNEAIMVYPGYAMAYYNRAILYTEQQQFDKAIEDYSTAISINPRAPEFYNNRGNLFFEAKKYDKAEEDYNKSLELAPNYSEAFHNRGMLYFCQSKLQEALQNFTRAIELNADLSINYYNIACIHSRLEEQDQALVFLEKAFREGFFDREKLNSDSDLDNIRSLPAFQDLTDRGGSMSPYTMAMKNFSTRRK
>NZ_AP019860.1|WP_151966906.1|1445974_1446631_+|hypothetical-protein
MEKWGAGIYLLGQYHRYQTGLWLLKHQDEAAILEMPPYFKSEVPPYKLCKTLCEDYNLKIKYFLCSHAHGDHFWQKTYDEIKKNFPQAKIYLQNGFKKRIKNKARTKFFEDEQRLYLANEPLILIHAPKHSPTDTMVAFRGTMFTGDWELNTIRSVHDGKKYAVPMETRLQSVQKMETFEERYNYNIHRVFSVHANDRRENVNFTELMADTKNNRQLW
>NZ_AP019860.1|WP_151966905.1|1445260_1445782_+|hypothetical-protein
MLLPEGETKDFLGREFLTWLWFYGEQNNWHFSFSDGDSMEYGMDELLVMQGDDANCMQKLSGPVPIKAPEAQVALLEGKKVSTTRVVFVHGQQEWTFTISGDNFNISSLKLISPTTSDIEERFAELSDDLEQVTLLFDKVYTTFLQLRISEEWHKDILPQMKEWVAQKAENAD
>NZ_AP019860.1|WP_151966904.1|1444643_1445252_+|hypothetical-protein
MHFLKSSLSFTRFKVIGNFSFAHEEFQNSLVQNSFVDLSELPDHEESIGWVSHENCLEEPDLSLMLMEPYIRLTFRIDKRKIPAALLEAHFAIEERATLAAEGKERLSLNRRRELKRQVKTMLMMRTSPNSSLYRALWNFKTQHCLLFATGKGLRNKFDKLFLETFGLELMPLTPWSLADIWAEKNNLDELLQETEPAEFNE
>NZ_AP019860.1|WP_151966903.1|1443109_1444642_+|aldehyde-dehydrogenase-family-protein
MSIDTAKVLENLGIQSQNYGAFNGEWFGSGEVLESISPIDGKKIATVVQATTEEYEKVYSEAEKAFKEWRMVPGPKRGEIVRQIGEGLRAHKDDLGALVTLEMGKIWAEGKGEVQEMIDIADFAVGLSRQMYGRTMHSERPLHRMYEQWHPLGVIGIISAFNFPVAVWSWNAMIAAVCGDTMIWKPSPKTPLTAIACQKIAAKVFVDNGLSPAVMSLVIGETETVGEKMIHDKRLPLISATGSTRMGKRVGEVVGGRLGRTILELGGNNAIIVSNNSDMKMVTRAILFGAVGTAGQRCTSTRRVFIHEDIYDELKEKLVSAYQQVSIGNPLDEGTLMGPLIDNLAVQSMQDAITEAKSQGGTVLCGGEVLQEDFPCGNYVKPCIIEMPNQSQIVQDETFAPILYLLKFNNIEEALHSHNAVPQGLSSAMFTTNVLEAETFLSHMGSDCGIANINIGTSGAEIGGAFGGEKETGGGREAGSDSWKAYMRRQTNTINWSKELPLAQGIKFGD
>NZ_AP019860.1|WP_151966902.1|1442405_1443017_+|superoxide-dismutase
MGFSIPDLPYDYNALEPHIDARTMEIHHSKHHAGYAKKLNAALEGANHAADDAEALLKDLNAVPESIRTAVRNNGGGYVNHNLFWEVMAPNAGGEPEGDLATAINETFGSFAAFQEKFTTAAGTRFGSGWAWLSVKDGKLAVSSTANQDNPLSEGATPILGLDVWEHAYYLNYQNRRPDYVKSWWNVVNWKAVAEKYAKAMGK
>NZ_AP019860.1|WP_173013140.1|1441832_1442294_+|HEAT-repeat-domain-containing-protein
MIVIACSPSQINLNEARSTDATAQDMEGYAQSDDPLLRESTAGNPNTPVSILEKLAKDQDEAVRRAVAENPNTTAAILQQLASDESWIVRDVVAFHENTDENTLRKLAEDSQYEVRLTVADNSKTPTDTLEKLSQDGNEEVQSLATKNLQMRK
>NZ_AP019860.1|WP_173013139.1|1440643_1441813_+|C40-family-peptidase
MKVFVWIFLFVTSLHAIEFSETLAKNIQSYIKPLLEKNLAQKTQRSQPRLGIEFSVSENQMNFFLSRRSQRDTLFSVVVRKEQQTLDTNAVVLYPEEKQIIKSALRIFISEYNANETIIVGPIAWGISKKGVCNLYVEPRDEAGDNLASQLAFGTPLLILESNEDNTFFRVQGCSDGYLGWINSRDFRFVTQDHWDEWNASVVTCNTKEIMLKNMAIPAGGRFALLSYKGKTIHVRDFANNKWEFAKEDFSMYLSQQEKIIDTARKFLPKSLLATQKYLWGGTTTPQTDCSGFVQLTYRMHNILLPRDSDQQYQYSKKIKLENAQSGDLIFFSKHGKHPTHVGLHIDNDLFIHCSASGPYSGVKINSLSGESDYEKYLRKIYYASGRIK
>NZ_AP019860.1|WP_151966899.1|1439386_1440481_+|type-II-secretion-system-F-family-protein
MANAGEAKKGKSLSLSFSKGVSSKELTTFTTQLSTLQDAGLPIVRSLKILAGQLKPGTLQRTIYTVADDVEGGSTFSEALSKHPKIFDRLFVNMIKAGEMGGVLDTILRRLSDFMEKSEKLKKKIIGAAVYPIAVLTVAGGILAIIMILVVPQFKEIFRDMGVDLPFITQLLINMSDNMASLWWVALLVIFAVMTIFRLIASNKRGKLMLDTIVLRLPVFGDIVRKSSISRFTRTLGTLITSGVAILEALQIVKNAIGNQIIARAIQAVQDSIREGESIAEPLANSGEFDDIVVNMIDVGEETGELDKMLIKVADNYDEEVDVLVTSMVSLMEPALIIGMGLVIGFIVIALFLPLIKLVQDMGQ
>NZ_AP019860.1|WP_173013142.1|1448332_1448482_-|hypothetical-protein
MKKHFSIDAELIASGGGVFEVVKDGELIFSKKKLGRHAEENEVVNLIKG
>NZ_AP019860.1|WP_151966911.1|1448560_1449454_-|UbiA-family-prenyltransferase
MKAYIVLLRPFTLLAPAIGIMSGSFVAWGVGYHEFHDPQWWILCKVLLGGFTGAILNGASNAINQIYDYEIDCINKPQRPLPSGKVSMRSAWIISVVLYVASLLIAFALSYEFAIMVFIAAFCTIIYSVPPLRTKRYWWSATLTIVIPRGLLMKVAGWGVLLPIWYTEAWYIGLIFGLFLLGATSTKDYADMEGDKRNNCITLPIAFGVKKSALMIAPSFIVPFLLFPLGVYLKVLHGNPLLLIFLGVSMCIWGSYVVYLILKDPHSLTTTENHPSWRHMYMMMVYAQVVLGVAYFI
>NZ_AP019860.1|WP_151966912.1|1449455_1449833_-|acyl-CoA-thioesterase
METNQQPSIRLTMLPKDTNGVGTIFGGVILSNIDLAGAVEVRRHTAKKVVTVSVKEVKFLSPVFVGDIVSFYTQTTKVGNTSITVEVRVVVDRWKDGYQTTLNVTEATVVYVAVDENNKPISIRN
>NZ_AP019860.1|WP_151966913.1|1449822_1450941_-|aminopeptidase
MNNIDFPNICELDKVAKHIVNKCLRVKENEIVNIRGGIHQYPLLAKIQVYVHKSGGYGILDIRDDETTVSLVNDVGDDYVGKIPEAVRNLQDHIDVDFILHPNYSLEVEKRKDTQKNALRNKRIAQYDRERTSRALIMEWPTIPKAKTYGMSLEQLQEIFWRAFWVDLDKLTAEAATIKEKLQGAKKVVVTSENGKTLEFAIGERPIWIDTGCFTEELVAAGDLTKNLPCGEVYCSPIEDSANGTVLFQKVFYNGNWIRNLELTFEEGRVTQVNADEGEEIFEEVLGMHSGDKDCIAELGIGLNPNVPETIGNILLDEKVVGSIHIAIGKNTMYGGINKSSLHWDLVAMHPTVTADGRTIMQNGKLELTHGN
>NZ_AP019860.1|WP_151966914.1|1451087_1452434_+|protein-kinase
MHIGNYNNRELLEVNLHYLHSQGKLTEETGFFLRRMYNYPHNIYSFIKEVWEAQGSKEIHTNTQYIDNRYTLVCKTPIGSGGMGEVYPFWDAQEQKVVAFKIAKLVCSASGENRRLLREGEVLKRLHEVHPNIVKYQDLRIEKFGDLFSEDAICLVMEYVEGRSLKEFALRKGLYWYDMCRRENRKLDQLLQSNIGYICTIAKALQTLHKKGLVHRDVKPTNIIISDDVPILIDFGIAQRIEAEGYLRTICSMASNIGTPPFMDPGTALSFIDLLHLQKDIQDKSWEEFLRNVKKPLLEYPTKMKPLKKKIKQIKTKLFVDKWLYNKPPKIDEVAWEEVEQIINEIRFCSDPKEDVYSLGATLYWCLTGETLFSTPEQARMYYHNPSKIHLVRRMNIVDFAQPKKITKVIKKLEKIIQHTLNPDPVKRWSCEKLIKALEPFANNLYAR
>NZ_AP019860.1|WP_151966915.1|1452439_1456186_+|HEAT-repeat-domain-containing-protein
MLFEHELHPEDILAYLPSCYQKAQVLAQGGMGWVYEAIYEGKKVCVKIPSLSSKNKMAEFMMRFQVERDVLFNLSHPRIIKGISRGEIEYCKDLTIPYYSMEFCSGGTLRDKLNDKLRLGKHEALSIVLEIAGALDYFHKTGCIYRDLKPENIFFDAHGKPKLGDFGTIKDPEIFLTQKGDIIGSFYYCAPEQLLNQKLDKRVDIFALGLILFEMITGRKIGDQITDFWKKQNALSALEYDPFLWELCSSMLAEKEHRIPVMSKVVDKIYESHGGAKKKLSVLKYYAKDWWYGKHFHRNSLHRSEIVNALQKITDLIEQYSIEDITLEIMRKLKPFPVHLIANEIPGFLTALPLSSNEKLAKALCSVRNRKWLSYLITHLVIHSAHDDTAILMTYMLAIDPQNQMLRKKISKALQQIWSEEQIEMLSQLIDENYANLNTFYGENHYAAFPIVLNILHKSDDLAIQKKCLEILSSISRALESTAVVFAKFFNSDDQDIREMCAVALGKMLPYSSEVLPYLLSGLLDPSHTVRCACALALGTKNRGITEVSALTTGLYDPNAMVRKACAKSLGKIGQAIPQVIENLVECLADRDSSVRKSCAQALDSLKWVPVNGQQMLWWQAAKENWSYLADRYQHARDIIEYLLLDTDNNIRISCVKIAEKDVEYLDVYIPLLILGLKNTRSKKYRRACAKALENLKWQANTRENYAWFLVENKEWDLLPLLGINCIPAIYQNLKDGDAQTRVEILRALTKIEGVDNKTIELISCGYSEKYRDVRMEYANCLALMDNFTTEDALHFMKRIDNFDENAQQFWSIVLENKSKTIQTLTQIQQENANMRISYVSSITPEQLDEAHIYFLLKQLQSRYVRFQLICLKALAQVSTSQRKIVKKIVARVLQLIKGDNPQLQVASAQIISTFAYVDKHVVAALTSKLDSKNNSVNQSVNLALVRLKDKAIPFLFSEITTCNNKEVLKAILLIVKKTYSNNLLCIGLRHNHPRLRLICAKRLRDTVRNKQDALAVIPNLIDGIDNMDLSFSDICLDTLQHISHRVEEDIDIFIQSLSHHNRKVRKVCKSIVTRKGKKATDKLIHYFVNGPSSISYRCAEILEQLGSKAIYNLMHSVAKDFNVREINKKITSSYLSISPDKKLELKKEDLNNRHLAISNKATSSFKMTSRIDLKGVKDLPITIDKNLRKTTPEYNSNFYNESCSGLRLANKDRSLGETINDIGLSPKSSNNEEPSRKNSPQIRIGKK
>NZ_AP019860.1|WP_151966916.1|1456377_1457832_+|hypothetical-protein
METMLFSDFQPASHQQWKDKISQELKERDFSEIVSQTDENFDILPFYQQADTAHLDMNCFSHSKECFYPQNTWKSFLPINNNSLEHGTQNLELIFDNFQGNSGISIEQDLDLVLKNIQVQNVDLCFTAGLQSIATLELIKKYNQKHNTTIRGSIDNDPIIELFIRGQIASSDDITRCKNVVESCAKLENFTGLSVQGQNFQELGANKVQELAFTFTAAIEYCDKLTDLGLSYETIVSNMQFSFGISGNYFLEIAKLRAAKLLWANIASQLNMSQCFPILLHGKTSIYNKSLQDSHNNIIRATIEAMAAISGGCHGLTIYPYDYPTSSKQGLRIAKNIHHILKEEAFFDQCLNAASGAYYIEQLTQQLANSAWKLIQQVEEKGGFLQATDFIRESITAQRQKKEQDFLQKKAILVGVNKYEMDNKPEKVSQPVEETTTTYGKPLITPQQVKEALKMHDYNTIAKSLCSYSIENSLPKYAPTTLAE
>NZ_AP019860.1|WP_151966917.1|1457837_1459091_+|AAA-family-ATPase
MNFKYEVENVAVHHNSLMILVGPSGSGKSTFVGKNFSESMRVSTDECRRMICGSHLNQRVSEDAFDIFYTIIEKRLKNGNPTVADSTALKRKYRQRLVKIAQKYKFKTVLILFDLPLHICMNQDKKRKQYAVGEKVIEQQYKNLQKTKMQIHEEKYDQVIIFNSSQQARSMHFRFTHPDVEKKDLGPFDIISSINGCYDELQVLLRKLGYQQNGKSEYYHPERRKLVVLGDICNKGPCNAETLQLIYNMWQNNCAYYVPGDECEKLYNFLKGDRVIKSRSLQSTQCELEDLSQQQICEFTTQFKELYERSSPYLILADGNLVVSHGGILGKWIGQLNKKIKSFCMHGDVKRSPWYKNYHGKAHIVYGHPHTKVAHWKNRTMNINLDVACGGQLCALRYPEKNVVTVNANKNYYKTKN
>NZ_AP019860.1|WP_151966918.1|1459105_1460461_+|endonuclease-domain-containing-protein
MSTFNPKTVEEFRFLDWQFDEKTYTASLRYAFDNDYIFTEKFIFPTPTFALTDEKRGALEMCLQNLHLAAGISYYKAAIPSKISIENYVISPETARFFNKLYLYGLGEFAYKNKVDLQGHISFPYVNEPFPSASKIELGHRTAIPVGGGKDSIVTIEMLKKLSIPLLLISIGNASPIAKTAEIAQLPHVAIKRELSPLLLELNEKGALNGHVPISAIISFAISVAAVLYDFNYIVMSNERSANIGNLWHDGLEINHQYSKSLEFEKDISRYLHNHVLDNLRYFSFLRPLSELMISKVFCDNCQPYHDIFASCSMAFRLTKSLEGRWCLNCAKCRFVFAMMAPFMPKEKLVQIFGKNLLDDSEQISGFREIMGLGKHKPFSCIGESEETIAAFVILSSNNEWKDNVVVAHFTEEILPTLTLPETYVENALLFSENHLLEKNEKDLLLENMNI
>NZ_AP019860.1|WP_151966919.1|1460762_1461311_+|hypothetical-protein
MKKLLVCMICAFLVMNVSADNKLKLKNVDKRKFKNASTEIQSAINWLKKPTPGYKHQVFFHLAYMETPAKWVGFCEGQLLLNKSKTKLSTRGGSAKVYFSDRRWDPKKSGGLLPTKPQLFDYRKAEKWNIELHSNGKMFLHMITWKQKFTIALSLRGGVLYGSVGRNVVIVSLKKSKYMIPK

Crispr_ID: NZ_AP019860_6

• CRISPR_ID: NZ_AP019860_6
• CRISPR_location: 1691505-1691744
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_AP019860_6

Consensus_repeat	Method
GGTTAAAGAAGTAAGTTGCTCGATTTCTTTTGG	CRT

spacers of NZ_AP019860_6

>6.1|1691538|36|NZ_AP019860|CRT
TAGTCTTGTCAGTCTGCAATTAGATAAATTCAACTC
>6.2|1691607|36|NZ_AP019860|CRT
CAATCCTGTCCACCGTGTGTTAGATAAGTCTAGCTT
>6.3|1691676|36|NZ_AP019860|CRT
TAGTTTTATATTCCCAGTATTAGATAAGTCCAAATC

CRISPR arrays and Neighbor proteins around NZ_AP019860_6

CRISPR arrays

The CRISPR arrays of NZ_AP019860_6

>merge|NZ_AP019860|6|1691505-1691744|CRT
TGTTAAAGAAGTAAGTTGCTCGATTTCTTTTGGTAGTCTTGTCAGTCTGCAATTAGATAAATTCAACTCGGTTAAAGAAGTAAGTTGCTCGATTTCTTTTGGCAATCCTGTCCACCGTGTGTTAGATAAGTCTAGCTTGGTTAAAGAAGTAAGCTGCTTGATTTCTTTTGATAGTTTTATATTCCCAGTATTAGATAAGTCCAAATCGGTTAAAGAAGAAAATTTATCAATTTCAGGTAG

>NZ_AP019860|6|1|1691505-1691744|CRT
TGTTAAAGAAGTAAGTTGCTCGATTTCTTTTGG	TAGTCTTGTCAGTCTGCAATTAGATAAATTCAACTC
GGTTAAAGAAGTAAGTTGCTCGATTTCTTTTGG	CAATCCTGTCCACCGTGTGTTAGATAAGTCTAGCTT
GGTTAAAGAAGTAAGCTGCTTGATTTCTTTTGA	TAGTTTTATATTCCCAGTATTAGATAAGTCCAAATC
GGTTAAAGAAGAAAATTTATCAATTTCAGGTAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967084.1|1683562_1685596_+|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|273938
NZ_AP019860.1|WP_173013154.1|1687768_1687924_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967088.1|1687969_1689136_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967096.1|1700113_1701196_-|peptide-chain-release-factor-1	unknown	unknown	gnl|CDD|234801
NZ_AP019860.1|WP_173013153.1|1679033_1680014_-|YndJ-family-protein	unknown	unknown	gnl|CDD|372935
NZ_AP019860.1|WP_151967097.1|1701359_1702094_-|hypothetical-protein	unknown	unknown	gnl|CDD|131480
NZ_AP019860.1|WP_151967093.1|1695507_1697019_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013156.1|1693631_1695194_-|response-regulator	unknown	unknown	gnl|CDD|274362
NZ_AP019860.1|WP_151967100.1|1704100_1705231_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967094.1|1697018_1697972_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_AP019860.1|WP_151967085.1|1685659_1686451_+|hypothetical-protein	unknown	unknown	gnl|CDD|379142
NZ_AP019860.1|WP_151967099.1|1703893_1704109_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein	unknown	unknown	gnl|CDD|214599
NZ_AP019860.1|WP_151967082.1|1681094_1682957_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|236861
NZ_AP019860.1|WP_151967095.1|1697975_1699679_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967091.1|1692076_1693555_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151967089.1|1689463_1690198_+|transposase	unknown	unknown	gnl|CDD|376616
NZ_AP019860.1|WP_151967081.1|1680022_1681072_-|alcohol-dehydrogenase-catalytic-domain-containing-protein	unknown	unknown	gnl|CDD|176244
NZ_AP019860.1|WP_151967086.1|1686760_1687186_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967083.1|1683192_1683396_+|YwbE-family-protein	unknown	unknown	gnl|CDD|378328

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967084.1|1683562_1685596_+|PDZ-domain-containing-protein	gnl|CDD|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	4.62493e-82
NZ_AP019860.1|WP_151967096.1|1700113_1701196_-|peptide-chain-release-factor-1	gnl|CDD|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0
NZ_AP019860.1|WP_173013156.1|1693631_1695194_-|response-regulator	gnl|CDD|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	1.12221e-99
NZ_AP019860.1|WP_151967097.1|1701359_1702094_-|hypothetical-protein	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	8.57402e-07
NZ_AP019860.1|WP_173013153.1|1679033_1680014_-|YndJ-family-protein	gnl|CDD|372935	pfam14158, YndJ, YndJ-like protein. The YndJ-like protein family includes the B. subtilis YndJ protein, which is functionally uncharacterized. This family is found in bacteria and archaea, and is typically between 222 and 269 amino acids in length. There are two completely conserved G residues that may be functionally important.	1.41919e-36
NZ_AP019860.1|WP_151967094.1|1697018_1697972_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.37746e-91
NZ_AP019860.1|WP_151967085.1|1685659_1686451_+|hypothetical-protein	gnl|CDD|379142	pfam13365, Trypsin_2, Trypsin-like peptidase domain. This family includes trypsin-like peptidase domains.	0.00138156
NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.42259e-18
NZ_AP019860.1|WP_151967082.1|1681094_1682957_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|236861	PRK11147, PRK11147, ABC transporter ATPase component; Reviewed.	0
NZ_AP019860.1|WP_151967091.1|1692076_1693555_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.35863e-57
NZ_AP019860.1|WP_151967089.1|1689463_1690198_+|transposase	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	1.09352e-16
NZ_AP019860.1|WP_151967081.1|1680022_1681072_-|alcohol-dehydrogenase-catalytic-domain-containing-protein	gnl|CDD|176244	cd08284, FDH_like_2, Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2. Glutathione-dependent formaldehyde dehydrogenases (FDHs) are members of the zinc-dependent/medium chain alcohol dehydrogenase family. Formaldehyde dehydrogenase (FDH) is a member of the zinc-dependent/medium chain alcohol dehydrogenase family. FDH converts formaldehyde and NAD to formate and NADH. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. These tetrameric FDHs have a catalytic zinc that resides between the catalytic and NAD(H)binding domains and a structural zinc in a lobe of the catalytic domain. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	1.11759e-151
NZ_AP019860.1|WP_151967083.1|1683192_1683396_+|YwbE-family-protein	gnl|CDD|378328	pfam09962, DUF2196, Uncharacterized conserved protein (DUF2196). This domain, found in various hypothetical bacterial proteins, has no known function.	2.31707e-28

Protein sequences

>NZ_AP019860.1|WP_151967089.1|1689463_1690198_+|transposase
MKEKEKMRPTRISMINGLFHVTTRCDNKNFYFREDEDFTEYLKIVERARKKYGFKLHAYCLTSNHVHLLLSTPVEDNLSKLMQYINGMYARIYNRRHKRTGHFWGERFYSTIVESENQLLSTIFYIELNMTRNGVTKHPKEWKWSSYNQHTKGKGPIEIDFHEIYMALGNTDKERRNKYITMMSDRIIQKGLLAKQPQVTYGLIFGSESFIKEIIGNHTNHRYYTNRKHFAVDETTFCLRKFKT
>NZ_AP019860.1|WP_151967088.1|1687969_1689136_-|hypothetical-protein
MFSQVVKKALITLSVLFILTSVSFAKLVEKGDKIVFNKNQFSKKNLIEIKWSQGFGTKYKEKYYKVSATCKGKGDLMLFVHKDYKDRLMSFAKLDKKKKKVTATVTNAFRYGQNRKKTRRFLVYHDRSFQPYQHRFLHAYVISMAKKCAKLMKKGSDSSAAKIAFGIVEKQLGKGVVDLIKKGIRSGAAEKAIDVAASTFGDNLRAYSGGLVESGDKIQFKEKDLSSRNLISVEWSQDWGKKYREQYYKISAACRGKRDVVLFVYRDYKDKLLSSAKISKKGEVTIRVNRDFRYGQDRKRTKRFLVYHDAKFKPFQHRFVSAYMIMAANKCVRLAKTNKMLLNKAYDLIENEVGESQVDAMKKIVAGGAMEKLIKAASSVVGDDLRSY
>NZ_AP019860.1|WP_173013154.1|1687768_1687924_-|hypothetical-protein
MNENNFFAVKELRERYVTWSKENGHYSLATNKLGMALKRLGFTQKRKNKCW
>NZ_AP019860.1|WP_151967086.1|1686760_1687186_+|hypothetical-protein
MDYYICVLDIFYSFTGDMMDRDLLEIVNQRKIKSVISKEKWNKLCLSFDKISPEVRYKSIDGNEIYGFSKVWWHELFSDSETIEWIDIKTVLTEFRGRLIPPKEIDISRSILKILEKFNISYTTGEKYFRIWCYISSESSQ
>NZ_AP019860.1|WP_151967085.1|1685659_1686451_+|hypothetical-protein
MYKLLLLFVMSGLLFAQEQQSETQATESSSKTQKQKILDIVDAHKDAVVSVQLVVKIPSMGNFERKLEIPGTVVNEQGLVIVSNSQADPMVAMRRRFQQGGPQNAKTEFTDIKIICNDNTEVPAQIAMQDEDLDIIFIKPKENKRKFAYISLDKTAKPQLLDDVVVIAKLDASTGRTPMIFHTRVMAIITKPSTYYVIFGISAGVPAFDENGKCFGLLLSRIGGGNAAMTNNSNIASAMAMLPMILPAEDILDVIADLEEEEE
>NZ_AP019860.1|WP_151967084.1|1683562_1685596_+|PDZ-domain-containing-protein
MNISQRCWCLVLVVMLFLQAQEKTVQQDQANNQVEIRKVMKKVYPALVRISVVTAFVAQGREQKAFTSGSGAIISPDGYVVTNHHVVGGAKRIWCTLSNKEEVEADLIGTDALCDIAIIKLKPWTMRVPVRSFAHASWGDSNELKIGQKVFAMGSPGAISQTVTYGIIGNLNMVIPKAIGGRNSFMLDGEAVGSIVRWIIHDATIFGGNSGGPLVDLDGKIIGINEIGIAGLGGAIPANTAKRVADSLIKKGYVERTWIGTRVQTLLKSDQRLYGVLVSNVTKGSPAEEAGIQSGDIVVEFNGTRISGRYEEQIPVFNALVFDTPIDTEVPVTVMRNDKELKLKLTTRARGKAKELDHEVLSWGITARNLTKLNTVRLRRDSKKGVFISSVRPGGPCGQAKPSLRVGDIITKISGMEVNDLNAMLELTKKLTAEKKTTTVVVEFERRKDQYLTAVQLGEEDKDSWARARKAWFPAKVQVLTTPLAKALGLEGKKGVRITRLYPQLTDGDFRLGDIITHLNEVSIDASNTSHSEVFPTMIRRFRARKKVDFTVIRDGKELKVNYKLPKSPKPSAEMKTYVNEHFEFTVRNMAVMDKIALNLPQDYKGALLKEVRTGGWLSLARIRTNDILLSINGEKIQNVNDVKKIMENLHKEKPSSVVFYVYRRGTHFYAEARPKW
>NZ_AP019860.1|WP_151967083.1|1683192_1683396_+|YwbE-family-protein
MSDGRNRQNVRIGQCVEVVKKRDQRTGNLTEGIVKKILTNSKFHPHGIKVMLESGEVGRIKNILEDE
>NZ_AP019860.1|WP_151967082.1|1681094_1682957_-|ATP-binding-cassette-domain-containing-protein
MIYINMQDVTLGFGGHPILENAHLQIHDNEKVAVIGRNGQGKSTLLKLLCGEITPEAGEIQKNQGLKIAYLGQEVPQDMSGVVFDILVQGLGDLGEAIVEYNAVSQKLAEESSDALLQKLEDAQKKLDDNGGWEQIQNVEEIISHLQLDSSEKFENLSAGKKRRVLLGKALVKKPDLLLLDEPTNHLDIPSISWLEEFFGRYSSSILFVTHDRRFLQKIATRIVELSAGALTSWDCDYETFLTRREDLLRAQEKEQQLFDKRLAEEEVWIRKGILARRTRNQGRVRRLKEMRDLYRERRKKMGNVKMGAQHAEKSGNLVVRAQNISFSYGNVPIINDLSLTIMRGDKVGIIGENGTGKTTLLKILLGELQAQKGDVHLGTNLQIAYFDQLRNLLDREKSVYENIGEGNDHVVINGRKKHVMGYLQDFLFSTKDANNPVWTLSGGEQNRLLLAKLFLRPSNVLVLDEPTNDLDIETLDLLEQLIIDYPGTVFLVSHDRVFLNNVVTNSIVFENDEINEYAGGYDDWLMQRPEVVKEKKQVTYSKPQREKKLSHKEKRELEQLPLKIEELEERQQKLYAESSDPQFYQKDKEEIATVQKELQEIGEELEKCYARWEELEELA
>NZ_AP019860.1|WP_151967081.1|1680022_1681072_-|alcohol-dehydrogenase-catalytic-domain-containing-protein
MKALTFCGKENIEFQEVADPKVTAPQDAIVKVKLTAICGSDLHVYHERETGLDHGTVMGHEFVGEVVELGKEVRNLKVGDMVTSPFTTSCGACFFCKKGLTARCVAGSLYGWVENGEGLHGGQAEYVRVALADSTLVKIPEGVTLTEALLLGDILCTGYFCADMAQISPEGAYAVLGCGPVGLLAILGARELGAQTIYAVDCVPERLAHAQRFGAIPINFQQQDVKEVILEKTQGIGVDAVLEVVGSNAAERTAVDIVRPGGIISVAGVHTANTFSFSPVEAYDKNLTYKIGRCSARYYMDKLIPVVQSKKYDLSSIISHRLPLADGKKAYEMFDKKCDNCTKVILENS
>NZ_AP019860.1|WP_173013153.1|1679033_1680014_-|YndJ-family-protein
MTNTFSFSINKVWLYQALLGMAAFITVCVLQPFVFLPSLGGIGYTISFAPLVIVPIALSLITIDQKHILQRIAMIFHFPAAICAVVSMCVNTGSTSAMLALPWLMQNLIIAVYGIVFFLTVCDREKPLFQQLPGVSVLMGCLYIPIAGVWLVSSNMGITFGFRSTIVLLTAAHFHYAGFALSVLAGLGGFAVDKNKRFVHKLYYTTGWVVVFCPVFVAMGIIFSPLLEMVAACTLAVAIIIFSATTAFGFSCRTWLSKIFFITAFLAMIATMALAATYAMSEYYDWHVISISTMAITHGVANAFGFTFLSLCAWLIEIKNKRSNNQ
>NZ_AP019860.1|WP_151967091.1|1692076_1693555_-|protein-kinase
MDNRILGKYEIHERIADGSIGSIFKGKDTKKGSLVAIKIVHEEHSNNRVFSANLRKAVVQAMQLEHPNLIKFYDVGEYKNRLCYVMEYVEGTSIIKQTLYRGRLTECWSLDIVTQIATALEYANSHGIIHQNLTPNHIILNARVKIGDLGLPIPEKADTTAIAPYLSPEQQKKEDLDTRSDVYSLGALWYYMLTNSIPFEKLNLQKLMDGSLEQSLETLQRYHPQIFWPSCEVIFKMTHKEREYRYQNFTQVLEDIEKVKRGPFNLPNKIPIKKFRHCFCPSEIDVRFGKIAIEKGWITQEEIEECLNYQEKYALAGAIVNLGQIMLDQEKITPQQKISLDKIEMEQLLDQIDAGFLEEANAHHLYPKDKIQELKKWQKQGVRGVAIGLSDQQPTDDKMRETILATVKHKMSIKKAKLMLETAVEGELLTQTRFDKTIRIYQAHRCFGRFVSVEEIILERGFMDKTVMAALKRAMARSELTGKPALNYLQER
>NZ_AP019860.1|WP_173013156.1|1693631_1695194_-|response-regulator
MCRYQDSREQLEERCSEVQNHNIALMNVLPDLLIKISRDGTFLYCTEDHDDLAMNLHDFMGKKITEIFPGNVGKQTMSYIQRALHYKKLQIFEYQIPVPMTSSNMQDYEARIVPCGDDEVFAIIRNITQRKKLENDLVRAKNVSDKTSKAKSEFLATMSHEIRTPMNAVIGVAELLGQTPLDKAQQKYVEMLSSAGKHLLYLVNDILDLSKIESGKFQLQREVFHLKKCVTEIVNIFEISAGEKNLRIDYEFNDNIDIWVVGDCRRVQQILANLINNAIKFTAKGCVTVGVDVNFVKERQVELQFFVKDTGIGIPQDRLTQLFDSFVQLDSSSTREYAGTGLGLAICKRLTQLMNGDISVESKLGVGSTFFFTLQTCIADEGENVGDEKEENSTDFAQLYPCKILLAEDNKVNQLILRNFFSHLGYEIDIVADGEQVIKHSEDNDYDIIFMDIHMPKIDGREATICIRESKSKNPVIIAITADAFDENKRHLLDSGMDDFLSKPITLEELKKVLKTYTPR
>NZ_AP019860.1|WP_151967093.1|1695507_1697019_-|hypothetical-protein
MPTVIFLRDLKRITSMKYFYWRRFLFVGCIFFFFCVAIASSHTNTAMGVHLLSFIAWATYVLLVLSASASAAMTIGEEIEKKTLGILVITHLSYRNIVVGKYIQQLFITCLNAIAPLPIFLFCISLGGVSLEQIVCILLSLLSTLLIAIAIGIFCSTLFNSKSSGSTAVTLMIVYQIAASYFFYLPISCFHSLRASIAGLDFSYCYYNFFWQCLFSAILVALAVRFLPFMYLWRNKVGFEVKINKALGKIALPSTKKKSKGKVVGQKIKGNPIAWRDFHMIHGGISGNVKKVILVMIIAFFLFLSFTNNSPRRFMQMMPSFLVILMLLFLMTFINSAIRCFSKEMESKSWQILLTTQLTNEQIVQGKMWGAFRSAKIFLMAYLIVLISYALIVFLSLPIKLSQIILSLSYIVWIVAYVANLFCCALFCSFYYKNHRRASNYFVLYFIIWHIMSGMLFSSQAIFWFGFTGVIINLIVAFLHMSVAMTFYNYLVRNLRLRIDFAN
>NZ_AP019860.1|WP_151967094.1|1697018_1697972_-|ATP-binding-cassette-domain-containing-protein
MSEEKKMAIDVKNLRKAFGNKIAVNNLSFQVPEGSITGFIGPNGAGKTTTLRILCTLLKPDLGSVKIFDLDTSTSATKIRHQLGFMPDYFGLYDDMEVYEYLDFFAAAYRIAAHRRGKLVDDILTLLDLTAKKHSLINELSRGMQQRLSLGRALVHDPKLLLLDEPASGLDPRARMELMELLRELRRMGKTIFISSHILAELKNLCDFVVIIENGKKIYNGTVSDAATTVEGDLSRIQITSAQDSQTVINILHAWRDDVKATLKGEKVTLVEYHNLQIKSSDIIAHLVKNDIQIEEAAKISANLEDVFMSLTKGGIS
>NZ_AP019860.1|WP_151967095.1|1697975_1699679_-|hypothetical-protein
MKIFIGVCIAFLSCLTFGEDIKMSIMSGYGNTLPNSASFEPVIVTVKNEGLKLIKGELRLSRGGLFSAASGRSYHREVVLPGKSNKVFTFYVLLSNSRTVISASLVADGQVFTHEQSFQARLSNHPIWINWKKDIKKNKYYDETYYAVANTPLIAFPRTPIALSNVAVMFVAEPQNFEVDEEQTAILQKWISHGGSLIFVGTSGLEALIQRRLPFLQVEFSSDSLLPAVTTLNCGRVVCFSQSKDHPYIQKLHSNTTFVKKTLQYSESVYREAYHSDLQRYMSRELSGEIQFAWMILLLIAYLICIGPVDYFITKKFKNRMLTWWIYIFSIVLFSFFAYIKGYVLKSGPMKIHCLNYIDVYDNGEAIGSTVFGVYSTRNANYTLRNTSQNGYFLPLNSDFTYDEETFDQENNRLVSRIPIYSSKNYIGVWQKTYPMRTQKIAFDANKRFDINIPQGFHVTDGYIMMDGELKRVLTVGETWYVDAVSRNSNSEAKKLLLGYSSPLKSSFYQYKVNIKDVEKMLDVTRNLKNGMAVVLFCDTDNHVQIVGEDPIRNEQSVLRYVVPALR
>NZ_AP019860.1|WP_151967096.1|1700113_1701196_-|peptide-chain-release-factor-1
MEQTTLQQMEARFSELEELIQKPEIMKNGSLYSKYLKEHGALSKIVNKYRELQTIKKERDEAKQILAEEKDSDMRAMATEELEELEQREAVVGKEIENLLITDEQQDNRNVIVEIRAGTGGDEACLFAQELFTLYAKYAERQYLRLEVLENTSTELGGIKEVSFSLKGKEAYKKMKYEGGGHRVQRIPSTESGGRIHTSACTIAVLPEVDDVEVDIKDTDLKIDYMRASGPGGQNVNKTSSAVRITHLPTGIVVSCQETPEQHKNRMKAMKVLRARLYNRMVEEQQKEINALRKDQSGSGDRNERIRTYNFPQNRVTDHRINHSIYNLESIMQGNIDEFVELLQVQEREEKLKKLGSIIQ
>NZ_AP019860.1|WP_151967097.1|1701359_1702094_-|hypothetical-protein
MENTRASIWRSGNKKNLVIIPGISTLLYPTIWKLLSPSYFSYYAKYFTVNVITFNHLPEKGTFLSVVEEYHKRLMQLQPYAVLAMEEGAFIAQHLATRQALKKLVLVSTSTKSNAKSQEVYEHWVRYVQQDRWQSLHKSMSHYFTNKHSFMKYLFFKKPQNPHQLTLLVEALKRRNSENFLPKINSETLIIGGDKDALISPDQYQKLLRLIPKSQLICVRGGCHHLYHQKKSTLEPNILHFLLR
>NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein
MNSIWNLRYHVAIFTLLFASIYIFWQLQKIDLLSSADVVEFVSELKQVDQTLNEEILEIRYFRRDNYNYMTKMVSELEEFPNRVKRSNIQRFLQDKIAFQQNFIQLETTLRKKLALVQNFKNLHGTLHRSLESFPKMVQKHMQEQPSAENELYFLLLKSFVHNFTNSEGAKADVERIVAYANKNNCKPIATMLKSIDQQRQDLDKTLSAILQSPTTTNLNNFFQQYKEYHHEQLRQFSYHKSALIIAFVLFIITLFLLLYSWQNKTQSTKPLTKICQELYDEVGNVGQTSDRLKKTSEWITTNGKQQNSAIQNTNILLREMTQVAQIHWQECAKAQEITDKADSSIRDSINHSHKMILAIKEMEAASYEASTILQNIQEIAKQSKIVGLNATIEAAKSDNEVFELVAQEVSSLAIRSAEALEETSSQILNSQERSRQGTNLTENILLYLSDTQFKIQSLEEKIDKMNAYFQKQKSSFETFGHAVDFVTTSIKKNDEFSQENAQLAENLHSLSSKLKKSVNTMLSISKEMAMKK
>NZ_AP019860.1|WP_151967099.1|1703893_1704109_+|hypothetical-protein
MDLQNLERAIRFLVYAHGHRLGTSDIAMTMLVSANTIHLTNTYVKLALHVKKIPKNHRAHCHIYFPMTLLP
>NZ_AP019860.1|WP_151967100.1|1704100_1705231_-|hypothetical-protein
MSVSVSKEIFYHKTHTCIHCGSIFSYVMKRTPHGMANSEEEAVKAFEANVIQAATGVDNHPCPNCGVVQPEMVAAKRKKHYIWQMIIFTCLFLITVLIAYFHVIHYTTAVLIHFCGAFSIVIWHLITNIHNPNNNLVAQRKIAKQREQHPAQLKLEKQGNLEGDIPPNEITHIYSGFLSALCALSLLFIITPEVVRTTKKWPLNPQWYPQIIGPNDTSRYYFKKAIYSIKGYWRGIAVANIFMEGQSFDAKATTNNNSWEQTISFESSERDTKSHIYAQVTMPSQSQLQNKEVLTVVYIEYKYPKFMGGNTYMIRDGQVEEKTSVKLAHANAGRQYLQLFYGGNVGGGLLLLLLLFVAHQRNKKFLTSTSQATILG

Crispr_ID: NZ_AP019860_7

• CRISPR_ID: NZ_AP019860_7
• CRISPR_location: 1720601-1720693
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_7

Consensus_repeat	Method
CAAAACCTTATTGAGCTAGATCTG	CRISPRCasFinder

spacers of NZ_AP019860_7

>7.1|1720625|45|NZ_AP019860|CRISPRCasFinder
GGTAATAACCACATAACGAAGATTCCAAAAGAGATAGGTAAATTA

CRISPR arrays and Neighbor proteins around NZ_AP019860_7

CRISPR arrays

The CRISPR arrays of NZ_AP019860_7

>merge|NZ_AP019860|7|1720601-1720693|CRISPRCasFinder
CAAAACCTTATTGAGCTAGATCTGGGTAATAACCACATAACGAAGATTCCAAAAGAGATAGGTAAATTACAAAATCTTATTGAGCTAGATCTG

>NZ_AP019860|7|6|1720601-1720693|CRISPRCasFinder
CAAAACCTTATTGAGCTAGATCTG	GGTAATAACCACATAACGAAGATTCCAAAAGAGATAGGTAAATTA
CAAAATCTTATTGAGCTAGATCTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967106.1|1715019_1715424_+|response-regulator	unknown	unknown	gnl|CDD|381113
NZ_AP019860.1|WP_173013159.1|1714366_1715017_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_AP019860.1|WP_151967117.1|1730122_1730947_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967101.1|1705485_1705710_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967113.1|1725784_1726399_-|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350236
NZ_AP019860.1|WP_151967112.1|1725372_1725792_-|hotdog-fold-thioesterase	unknown	unknown	gnl|CDD|239527
NZ_AP019860.1|WP_151967103.1|1708129_1713508_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NZ_AP019860.1|WP_151967110.1|1723284_1724337_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_AP019860.1|WP_151967115.1|1727175_1729029_-|hypothetical-protein	unknown	unknown	gnl|CDD|226483
NZ_AP019860.1|WP_151967099.1|1703893_1704109_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013161.1|1724806_1725358_-|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NZ_AP019860.1|WP_151967116.1|1729139_1730126_-|histone-deacetylase	unknown	unknown	gnl|CDD|212518
NZ_AP019860.1|WP_173013158.1|1705926_1707759_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|215135
NZ_AP019860.1|WP_151967100.1|1704100_1705231_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967104.1|1713526_1714180_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_AP019860.1|WP_151967107.1|1715620_1720159_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein	unknown	unknown	gnl|CDD|214599
NZ_AP019860.1|WP_151967114.1|1726404_1727166_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|179371
NZ_AP019860.1|WP_151967118.1|1730957_1733165_-|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013160.1|1722157_1722874_-|transposase	unknown	unknown	gnl|CDD|224854

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967106.1|1715019_1715424_+|response-regulator	gnl|CDD|381113	cd17569, REC_HupR-like, phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains. This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.96669e-18
NZ_AP019860.1|WP_173013159.1|1714366_1715017_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.54285e-37
NZ_AP019860.1|WP_151967113.1|1725784_1726399_-|NYN-domain-containing-protein	gnl|CDD|350236	cd10912, PIN_YacP-like, PIN_domain of Bacillus subtilis YacP/Rae1 and related proteins. Bacillus subtilis YacP, also known as Rae1, is an endoribonuclease involved in ribosome-dependent mRNA decay. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. PIN domains were originally named for their sequence similarity to the N-terminal domain of an annotated pili biogenesis protein, PilT, a domain fusion between a PIN-domain and a PilT ATPase domain. The structural properties of the PIN domain indicate its putative active center, consisting of invariant acidic amino acid residues (putative metal-binding residues), is geometrically similar in the active center of structure-specific 5' nucleases (also known as Flap endonuclease-1-like), PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	4.52109e-16
NZ_AP019860.1|WP_151967112.1|1725372_1725792_-|hotdog-fold-thioesterase	gnl|CDD|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	2.2925e-25
NZ_AP019860.1|WP_151967103.1|1708129_1713508_+|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	4.41357e-172
NZ_AP019860.1|WP_151967110.1|1723284_1724337_-|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.70415e-14
NZ_AP019860.1|WP_151967115.1|1727175_1729029_-|hypothetical-protein	gnl|CDD|226483	COG3975, COG3975, Predicted protease with the C-terminal PDZ domain [General function prediction only].	8.79212e-57
NZ_AP019860.1|WP_173013161.1|1724806_1725358_-|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.08257e-11
NZ_AP019860.1|WP_151967116.1|1729139_1730126_-|histone-deacetylase	gnl|CDD|212518	cd09992, HDAC_classII, Histone deacetylases and histone-like deacetylases, classII. Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.	6.04745e-129
NZ_AP019860.1|WP_173013158.1|1705926_1707759_+|methyltransferase-domain-containing-protein	gnl|CDD|215135	PLN02244, PLN02244, tocopherol O-methyltransferase.	6.16364e-37
NZ_AP019860.1|WP_151967118.1|1730957_1733165_-|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.8665e-108
NZ_AP019860.1|WP_151967104.1|1713526_1714180_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.37587e-62
NZ_AP019860.1|WP_151967107.1|1715620_1720159_+|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.69325e-83
NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.42259e-18
NZ_AP019860.1|WP_151967114.1|1726404_1727166_-|MBL-fold-metallo-hydrolase	gnl|CDD|179371	PRK02113, PRK02113, MBL fold metallo-hydrolase.	8.81957e-99
NZ_AP019860.1|WP_173013160.1|1722157_1722874_-|transposase	gnl|CDD|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.13052e-15

Protein sequences

>NZ_AP019860.1|WP_151967107.1|1715620_1720159_+|AAA-family-ATPase
MKLAETFLNIAADATIYLETEDPLVKDRLIHELDKSFSLLYALSSEIEAPYTKKYVDFVADNHTQNLIALLESDESCLQGVPDNISKWQNQCLVKLSNTYRYWKENIAQGQLRAYFVVAFNNVGLLSSLRMSSYNPLPYQRIQGSGYDTSIARSLDDARKIIKYYWQAKYKLPTSEVDKNLEAWAVEWGSSLLSQFKNRPVTGQSFSFTFTIFFFISSLRKLCEQGVLEVYHHDSHQKIEPHCLNLPSNMVASGAFIRDQIPDESLTPKQYNNIATKKIAHIQTKLEVISQANSVCHEPFIEYFLIPKDNYFDIETQDEKIVIVPIENLDDLITKFFPNWLIRSKYQTSEQPKSHINIEQFVQQGQQLALQLSKIHRQNKIYKHLTLSCITSTLGSSHVDWIPPTEAMSIALVNPKSTMAYIAPEQTDYYNVNIDQRTDIYSLGVIFYQMLTTKLPFSAENVYEFIVAHVSQKVIPPHDLFPQIPPALSRMIMKMLAKNPDDRYKSVAQIAQLLVAYKNNDTLQVTDAYENLVFPRKMYGRKSEYQQLQKSWQNFLDGNNEIVVVYGMPGIGKTDLVNSLLRDVLEQGCFFFTGKYRQNNKQPSYNAWIEILQKFCRQVLSSSPQNVTKWRNMIMDALGTNVSVVAEVVPDFDNLVGKQEPSSPLPPEESRNRFYFVMEQLFDVIVTNSNKITVFIDDIQWTDDASLLLISRFLGKYPQKLFFIFASRNSETSCQKTAHLQELIAAKGIKIKKIFLSPLSLFAVEKILTHLFSPTPNNIRLLSSFIFQKTMGNPLFVKQLLEVLYREKLLYFEKETRTWSWDLSIIEKLNFSNDILDSLRKKTTSLPKEYQDLLQICSCLRENFSTKMLGGIICKYQDCITDFINEATQQHYIVATQSQWNTLSTEHTYKFTHDLVHQSIHASIDEKTKAQIHYDIGSYYFRQDDLSPSKVAVHWNHCIPQLKNEEKKQLAKFNFQAAIRAKNAASYTKAFMYIQHIQKIAQQIKLETKFMSQVSQQEAELAYLSGNFRQAEKLFMQMIANTKDKVEIAQIHAYLVVLYTHIGDWDQSFKVGKKGLSYLGIHWSSRSVLFTLCKEFFRIKRNLRKLKTTPDYFVNVCKLQDKEQEIALQLLSIFMHTTYYGGKLYAFLTALKMVNITIENGFTVDSPNGYAYFAMLLGHLKTLGSYTLGRDFMEWAITLSQKYNNPLHTGRVYFTFGAVVNHWTREFKLNLHYLQKAKKYSIQGGDLMFASYAAVHPLQVYFFSGKNLQELFEETNIRQDFLEKVSFTSQEFFPIGLQKFIVEMSDVSPSRIRKNLTLNYYRNKQQKIKNTTGIIWLETLELKKLYLQNNYQEAVNVATNSLPYIDGAFGQIMQPEYYYYFTLSLLALYSQEKPRKRLNRRIKKNFAKLTTWKNNCSQNFEHKYLIVKCEILRVQHNFVAAMKLYPQAITIAKQNGFIHQQALANELAAKLYIQLGINDTAKMYMQQSIACYEKWGCTMKVQQLSKLLDSVN
>NZ_AP019860.1|WP_151967106.1|1715019_1715424_+|response-regulator
MNIDILIVDDDYLTILYMKEMLMVLGCEVQCANSAQMALEILTKNQIDLIISDVNMPETDGLEFFLQIQKLHPLLADNFILISSNVCEEQMKEIKELQLSLYQKPLSLVTLTKIVAKNFGSDLLEGSKSKFNKL
>NZ_AP019860.1|WP_173013159.1|1714366_1715017_+|response-regulator-transcription-factor
MDTPQAKQIFIVDHPIIQDGLENIFQFENDLKICGRANSSEETLKHLPSVKPDLMIADIFLKGIGGLDFVENIRRAGYTFPILVLSIYEGISYAEQCVGAGIEGYIPKKEKTSTLLKAIRNLLNGQIYIDEDLKLEIIKKFFMSDSLSVFSPKLILTEEEQKVYNFIGDGCPIETIAKLLNLNAKKIILFREQIKKKLYFKDNVELLQSAIGYRKG
>NZ_AP019860.1|WP_151967104.1|1713526_1714180_+|response-regulator
MSSTRVVLIDDHPVVREGLAMSFQQTDDLVVCGEASDYYEALEVIDELQPDVAVMDLSLQGMGGLDLIKTLRKKGHKLPILVLSIHNESFYAERAIRAGAQGYIMKQEKTEEVIKAVRQVLQGKIYVSRELSDSIMYKFFDKNPSSDSPLDRLTDRELEVYQLIGQGVSPHKIADDLCISIKTVDSYRARIKEKLNLKSGTELLQSAIQWVQSQDLG
>NZ_AP019860.1|WP_151967103.1|1708129_1713508_+|AAA-family-ATPase
MLTLQGYKITERIYEGRETEVFKGYKNQQALIFKSLKGEYPSRRALARFRREYEIVKNLDIDGIVEVVDLVEYRNSLVIVLKDFGGVPLSKVIADKKITIDIFFPIAIAIVKILGNIHKHNLIHKDIKPSNIIINYDNLDVKIADFGISTFLSREVPQVRNPKLLEGTLAYMSPEQTGWINRGLDYRTDFYSLGITFYQMLTSRLPFSGKDALELMHAQIAKVAPSPHKIEDIPPSLSLIVDKLMAKTVKERYQSARGLLLDLEDCFSKWRDNEIHLFVPKNAEISERFQLSEKLYGRDKELEILLNSFNEVSKGRMETLLVCGHAGTGKSTLIHEIYKSVLAKKGYFITGKFDQKERNVPYSGFKSAFKKLIVQILGENEEVIYLWRRKLLKAFADNGQVLIDFIPEIELIIGKQPTLEKLPGTESQNRFNVVFINFIRALAQQESPLVIFLDDLQWSDSGTQNLLKLLIDNSLPHLFLLGAYRDNEIDGSHPLAMTLESIEQKHLIKKISLSPLTFPYVNKWIADSLNTSSEKSQSFSQLIFRKTTGNPFFVKQFITTLYQDGILTFDDKTNCWQAPLEEIQQMNVAENVVAFMAEKLSKLPSSSLELIKVAATIGNTFKWQLLATVLEQKITEIKHDVEELVKKGFIFPVGTFDITFVSDEFLEEISFRFAHDKIQQAAYSLIEKEYIKDIHLSIGKIIAQKSPEMIFQLVYHMNLAMDLLSQNEKLQLVEYNLQAGKKAMSSAAYSSACEYFIAGRTLLPENAWENLYPLTLSLHSKAAECEHLNGNFENAKKLFSLSLLHVKSNVERADIYNIKITFHTNLGEHQQALSLGKEGLIFFGIQVPELPGKGTVLQEVLKVKWLLRGKKTEQLLYLPEMVDPNALAAMKLLMSISPSTFFVSPNLWAWGILKMLYLTLKYGNTPISAFVYVCYGIIVGSGSGNYKKGYDFGKLAIEVAEKYGDLRLKTKAFNLFGSLVGHWQQHAIDDIDYLLKAYHTGLECGDLMFACFSLTYVVNKMVITGKNLDEVSQKIKDYSRFFDQLKFQDAVRVYWGIEQMIKSLQDVPENALMQNIEAESTFQEMQTATNQMPLHWHYINQLQVFFIFGRYSQALEMAQKSQEMLSISFGTMQVPVQNFYHSLTLTAIYHKQSHANKRISKKILQENQKKMKKWAKNCPQNFSHKYLLVQAEIARINNDEKEKIIELYEQAIHKADETKYTQNKAIACELAAKFFLAQGKAKIARVYLEEACYSYNKWGAIGKVIDLTRKHTSLLPKKDNSNFTLRSHEIETTISTMVGHLSHLNINTVIKASQAISREISLDKLLVRLMEIALENAGAERGFLILNRDNQLFIEVRQSTDQSKAMLQSIPMDNCAEIPITIVNFVRRTMEKVVLHDAFKEGGFQSDPYVIAKKLKSVLCIPILKQNELLGIFYLENNLTPDVFTPDRLEVLEMISTQSAISIENAKYYEGMKQTQRELQQSETKYRLLMEQASDAILISDKEGNYLDVNSRACEIFGYEKKQFLQLQLSHFFPQRFINLAELESGKTTGAELQMKRGNGTLFPSEFNMKLISDGRIQTIIRDITERKRLEKEVLEISSREQQRVAQDLHDGLGQQLTGIKYLSEALARSLSEKSLDEATKMERISQLVAEAINSTRGMAKGLYPMILQSNGLTVALSELAHNTSKIPRVSCEFNYDSNIEIKDPAVANQLYRIAQEALNNAIKHGGAKNISISLNKENDKNILSVRDNGKGFPEHIKKGMGLNIMKYRAGVLGGDLQIVRKKKNTYVICSF
>NZ_AP019860.1|WP_173013158.1|1705926_1707759_+|methyltransferase-domain-containing-protein
MRLMEQEKFTGINFHPATNEFIYRYYQSLPQIDAFQARSENLFIWTYEGSRQLVLDRVPEISHEVLYNTNVIAVLLNVMIDDIADMILDEKLLHGTLEILETGQDHHGILHSFPEWQMYLSLLMDIRNYLNETIKTWPQYALWISDLVFFIRRLKTAMMGSLYFNQSFHNSKTSNWNFEKYVVEMSPPIHTFIYGIFNLMLIEELEYKEREAIVSALYQGEQFMAMSNWLSTWEVEIEQSDYTSGVVLWALNNNILSKEELNDVPHAKQKIQKSVCISDFAEKMEEKLSIIQGLRSRVSTFSLEKYIEDLREVHDLHMNFNKMLKYQLENEIMLSHEEKRKITEYYSQADKSYQNWGNSVYELHYGYRDHPQDKHHTSLIRMNEEVAQEAKVQKGDRILDAGCGVGASVIWLAKNFDATASGISLSPLQVEKANKFMHEHQLESRVDFSVQDFTKTNFPDNHFDVVWGLESICHAIDKKDFIEEAWRILKPGGRIVVGDTFLVREELSEIEEHALRKWLDGFAIDNLASTKSFIENLENSSFQQIKVRDITENIMGSANEIYQRGKSGYPDDLINKNKSIVQIKHVEACLFQKICLDFGLWRYQIISAQK
>NZ_AP019860.1|WP_151967101.1|1705485_1705710_-|hypothetical-protein
MEVNTMDFMQAYTIANKEGWIVYFDLRLKHWGVGRSLIGDDRICFYPGKSIAELRDLFIVLCEMKGLKNPQMYM
>NZ_AP019860.1|WP_151967100.1|1704100_1705231_-|hypothetical-protein
MSVSVSKEIFYHKTHTCIHCGSIFSYVMKRTPHGMANSEEEAVKAFEANVIQAATGVDNHPCPNCGVVQPEMVAAKRKKHYIWQMIIFTCLFLITVLIAYFHVIHYTTAVLIHFCGAFSIVIWHLITNIHNPNNNLVAQRKIAKQREQHPAQLKLEKQGNLEGDIPPNEITHIYSGFLSALCALSLLFIITPEVVRTTKKWPLNPQWYPQIIGPNDTSRYYFKKAIYSIKGYWRGIAVANIFMEGQSFDAKATTNNNSWEQTISFESSERDTKSHIYAQVTMPSQSQLQNKEVLTVVYIEYKYPKFMGGNTYMIRDGQVEEKTSVKLAHANAGRQYLQLFYGGNVGGGLLLLLLLFVAHQRNKKFLTSTSQATILG
>NZ_AP019860.1|WP_151967099.1|1703893_1704109_+|hypothetical-protein
MDLQNLERAIRFLVYAHGHRLGTSDIAMTMLVSANTIHLTNTYVKLALHVKKIPKNHRAHCHIYFPMTLLP
>NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein
MNSIWNLRYHVAIFTLLFASIYIFWQLQKIDLLSSADVVEFVSELKQVDQTLNEEILEIRYFRRDNYNYMTKMVSELEEFPNRVKRSNIQRFLQDKIAFQQNFIQLETTLRKKLALVQNFKNLHGTLHRSLESFPKMVQKHMQEQPSAENELYFLLLKSFVHNFTNSEGAKADVERIVAYANKNNCKPIATMLKSIDQQRQDLDKTLSAILQSPTTTNLNNFFQQYKEYHHEQLRQFSYHKSALIIAFVLFIITLFLLLYSWQNKTQSTKPLTKICQELYDEVGNVGQTSDRLKKTSEWITTNGKQQNSAIQNTNILLREMTQVAQIHWQECAKAQEITDKADSSIRDSINHSHKMILAIKEMEAASYEASTILQNIQEIAKQSKIVGLNATIEAAKSDNEVFELVAQEVSSLAIRSAEALEETSSQILNSQERSRQGTNLTENILLYLSDTQFKIQSLEEKIDKMNAYFQKQKSSFETFGHAVDFVTTSIKKNDEFSQENAQLAENLHSLSSKLKKSVNTMLSISKEMAMKK
>NZ_AP019860.1|WP_173013160.1|1722157_1722874_-|transposase
MRPIRLSMINGLFHITTRCDNKNFYFQEDEDFTEYLKVLEKAREKYGFKLHAYCLTRNHVHLLLSTPTEDNLSTLMQYINGQYAKNYNRRHKRTGHFWGERFYSTIIESETQLLNSIFYIELNMTRNGVTKHPKDWKWSSYNQHSGCKGPIKIDYHEVYLRLSSTAQDRQKKYTSMMEEKMVQKGLLSRQPQVTYGLIFGSESFVKEVIIKCSSHKYYKNRKTYSIDQETYCLRKFKT
>NZ_AP019860.1|WP_151967110.1|1723284_1724337_-|tetratricopeptide-repeat-protein
MRIIIFFLLFSTHILASQLYSKGMAHFFYTYGSHCYSQKNYSEAIQNYSAALKFAPNHCWTLHRLGNCYLVTKKYEKAKNFYLQATNTDNPPLFSYYNLGCIYALQNDKKNALIYLEKTIQKGYTKLEKLEVDSDWSSIRTENKYQQIIQDAKKIKTQHSLIEEYQNSGYQNKMRILQESISKNFPKKLDLAILTLNETYEGYRVASIALLSSLSPKESSEYLIVALFDANGYVKKAAANAIVKSAINVQQQLISILQKPNSPATPYVIQILGHINSTNSIDILIPYLKDEDPFICISTVDSLVRLKAISAIPVLEQISQQMKNAKTPQKEFYQIKIQHAISYLQKLKHK
>NZ_AP019860.1|WP_173013161.1|1724806_1725358_-|FHA-domain-containing-protein
MERIKPCLYDERKNLKFELEFDRDNKIGRGTSPRAKNITISLINESVSSNHATILCRKGNWIFCDESTHGSQVNGKIVHNNTVPIRHKDIIQVGEYSFVFFDEDAISSIGGTQEFSVKGVNLGNSTIEQAMHHLTNSAVERATHHYDQWQQDRRPEVVVIAFACMILFMVLFIGIFFNFFFQL
>NZ_AP019860.1|WP_151967112.1|1725372_1725792_-|hotdog-fold-thioesterase
MSDINKLLDMFNNKAPIAQLFGMKLSFDENNNAKVHLPYNPNLDHALGLVHGGIYATMLDNAGWFTVAAHSETNNFWIATSEMSIHFLLPAKQTSLLATGKIIKYGKRQSIAEMSLFDGNDNLVGHSTGTFIQLSNVSM
>NZ_AP019860.1|WP_151967113.1|1725784_1726399_-|NYN-domain-containing-protein
MIVIIDGYNLLFHDSWPYHEGALEDRRKKLIDLVVSFKQKKRIARVIVVFDGCAGIGPYKKQTSQQGIEIIYAICQGKADEKIISLSKHLNNVMVVTADRRIIKYTKRNRSSITSPQSFTQELLKTQRRTTPKQMSLPTNDVDEWLEEFGLDDEVEIPKNFDEKLPQVPEYTEEQTQEEDDALLDEESVEDWMKWFRFKEGDYE
>NZ_AP019860.1|WP_151967114.1|1726404_1727166_-|MBL-fold-metallo-hydrolase
MKVTFLGTGTSQGVPVPMCDCKVCRSTDHRDQRLRCSVYIEYQGKDIIIDTGPDFRQQLLREKIMHIDGILFTHSHHDHIAGLDDVRCFNFKYKKPIGIYTSAAVEQRLREVFSYIFSEVQYPGAPQVYITRIKDKVFSVKGVEITPLQVLHGKLPIFGFRIGDFTYLTDTSFIPESENEKIQGSKVIVLDALRQTPHPTHLHLDAAIDIIKKFQPQKAYFIHMSHQMGLHDEIEKLLPENMHLAYDGLKIEV
>NZ_AP019860.1|WP_151967115.1|1727175_1729029_-|hypothetical-protein
MRLILALFLATLLSIQAEDYMTLHVDATDLTRGLLTSEMEIHTSDTEIVMWYPKWIPGIHGPRNPVENLGGVYFYSEKGEKLKWHRNSHEPFRFICKLDQDTKKVRIKLRYICNQPNGNSTGVDSYGNSQMGVINWNTVLLYPAWKNNQIKVRTKLTLPKGWKYASALQTKSQEKQTITFKTTTLEELIDCPLICGQYFRTVDLKVNNFPPHYLHLVAESSSDLNIPEKLIQKYRRCVQQAQKIFFKPHFREYHFLVFMSNRLPSMGLEHLSSSLNGIGEKDFFNAWSLKGWVGSLLPHEYVHSWCGKYRRPIGMHTPDYHSNKDTRLLWIYEGLTTYLGEVLAVRSGFLTPEEYIPRFTRKLNYLMKQTGRSWRPLEDTCVCTYTLRQRSKNWGVWRRGQDYYDEGLLLWLEIDTMIRHRSFGEKSLDDFCIQFFGKGNSGQALAFDLLEVYQILDNIVQYDWKNFIEGRIKEPKDKLPLNLVNLCGYRMIYTNKASRYLQELQRRRKYIDASDSLGILFSYDGQIRKIIPGMVGDQSGIAPGMQVTGINGQKFTVSNLENAIANSIVTGKIELLVFERYTYKILTLKYDGGAKYLHLERVPNSPDMLTKILRPVK
>NZ_AP019860.1|WP_151967116.1|1729139_1730126_-|histone-deacetylase
MKTYFITHDTCVKHSAGAGHPENGQRLQAIFDALAEKNIALEKRIAEKVSVDYLPLVHTSAHIEKVLAAHGKKTMFDADTHTNEHSVDAALYAAGAGVEAVDLVLQEPGSTAFCAVRPPGHHAESNRVMGFCLLNSVAIAAAYAIKYKGLQRVLIFDPDVHHGNGTQEIFYHRGDVFYASIHQFPHYPGTGRYEEKGVGDGVGKNANYPLRCGEGDETYIYLAQHAIVDIIKEYKPQLILFSAGFDAHELDPLGGMQVTCQGFCAMYSVIMRHALAEKIPFVYTLEGGYSLNALSSSIHLLLETITTESWPQVSRVIPPEYVKKLLHQ
>NZ_AP019860.1|WP_151967117.1|1730122_1730947_-|hypothetical-protein
MRNRFSYNRVFIPEFFSTVVISIVVTLLTGFWFSKTVHQIDSIHKTPSIVLYTILIIFALYISIYFRSKYSYFVVDSKGLERKGSWYSVPFVGFDQVRTVRESRGEFFGKESRFLYIELKNNEIIRIYDYIFGYDELYAMIEKGIGQKISEDAFLTHGHIHNFANENYANLSQKLKAQSKKRDKVFGDPSNFYDKIVELGRRILCLLPVCATDFYLKIMIDTVFGKNKDVPTVLSFYSSFISLLISIMVARYVYFNLFSYEKGFRYHFKVKKHL
>NZ_AP019860.1|WP_151967118.1|1730957_1733165_-|PQQ-binding-like-beta-propeller-repeat-protein
MSKEHDIYIGQFAVSIGIISAQQLSVCLKLQAQYHQNGEYYSLLDILRHKNFISQSQIHILQKTTTGEGNQTLSANQVPLKIANRYQVLQELGRGGMGIVYRAQDEVFEREVAIKILRNFDGNHKMSARFLREAKAMAKLKHPNIVEIYDIGMEKDFHYFTMEYVKGKNLRTLMQSKKISVREAAKITIKILNALQHAHSNGIIHRDIKPDNIMISDKNVKVMDFGLAKMVEEKVRISQTGNAVGTVHYMSPEQMLAQRSKISYTTDIYSTGVTLYEILTGRTPFVAKSFAEAVKKINRPFTTPHEIKTKIPRQLSAICMKALQKKISKRYQSAEMFLEDLQNFVQSKQNVHAVRHSSRTLPIFGVIILCAICLLTLPLLSNKNKSETVRKVAPQKKTPTILYRGNLRRTGFYNTKPLTNVSQIRWSLPTKKRIKSSPVVSDNIVYFAGYTHKVYALGVQSGKTIWEFTANDLIYSSPAIYDNVLYIGSHDGYMYALEKKNGTLIWKFRAQDSILSSPAFNEGMVYFASHDHKIYAVNARTGKEVWSHKTGDKILSSPAIFDKTLFIGCNDGFLYAIKANSGELRWRFATNGVIKSVPAIDDNAVYFGSFDHHVYAVSHKGELLWRFKTGAEIHSSAAIKELIYVGSNDGYFYALDKNTGKLKWRNATKSPVVMSPCIFNNVLYYSSLDGFLYCAYRRDGRILWRQKLNCTFSSPTIGHNTLFCGGIDGTIYAVD

Crispr_ID: NZ_AP019860_8

• CRISPR_ID: NZ_AP019860_8
• CRISPR_location: 1720713-1720904
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP019860_8

Consensus_repeat	Method
AAATCCCAAAAGAGATAGGAAAACTTCAAAATCTTAC-------GAGCCTCTCTTTATACC	PILER-CR

spacers of NZ_AP019860_8

>8.1|1720767|35|NZ_AP019860|PILER-CR
ATCTTTGTATATCTTCTAATCAACTAACAGAGATT
>8.2|1720856|15|NZ_AP019860|PILER-CR
GTAACTGGCTGACGG

CRISPR arrays and Neighbor proteins around NZ_AP019860_8

CRISPR arrays

The CRISPR arrays of NZ_AP019860_8

>merge|NZ_AP019860|8|1720713-1720904|PILER-CR
AAATTCCGCAAGAGATAGGAAAACTTCAAAATCTTACGAATCTTTGTATATCTTCTAATCAACTAACAGAGATTCCAAAGGAGATATTGCAACTTCAAAATCTTACGAGCCTCTCTTTGTACCGTAACTGGCTGACGGAAATCCCAAAAGAGATAGGAAAACTCAAAAATCTTACGAGCCTCTCTTTATACC

>NZ_AP019860|8|1|1720713-1720904|PILER-CR
AAATTCCGCAAGAGATAGGAAAACTTCAAAATCTTACGAATCTTTGTATATCTT	CTAATCAACTAACAGAGATTCCAAAGGAGATATTG
CAACTTCAAAATCTTACGAGCCTCTCTTTGTACCGTAACTGGCTGACGGAAATC	CCAAAAGAGATAGGA
AAACTCAAAAATCTTACGAGCCTCTCTTTATACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967106.1|1715019_1715424_+|response-regulator	unknown	unknown	gnl|CDD|381113
NZ_AP019860.1|WP_173013159.1|1714366_1715017_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_AP019860.1|WP_151967117.1|1730122_1730947_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967101.1|1705485_1705710_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967113.1|1725784_1726399_-|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350236
NZ_AP019860.1|WP_151967112.1|1725372_1725792_-|hotdog-fold-thioesterase	unknown	unknown	gnl|CDD|239527
NZ_AP019860.1|WP_151967103.1|1708129_1713508_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NZ_AP019860.1|WP_151967110.1|1723284_1724337_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
NZ_AP019860.1|WP_151967115.1|1727175_1729029_-|hypothetical-protein	unknown	unknown	gnl|CDD|226483
NZ_AP019860.1|WP_151967099.1|1703893_1704109_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013161.1|1724806_1725358_-|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NZ_AP019860.1|WP_151967116.1|1729139_1730126_-|histone-deacetylase	unknown	unknown	gnl|CDD|212518
NZ_AP019860.1|WP_173013158.1|1705926_1707759_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|215135
NZ_AP019860.1|WP_151967100.1|1704100_1705231_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967104.1|1713526_1714180_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_AP019860.1|WP_151967107.1|1715620_1720159_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226415
NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein	unknown	unknown	gnl|CDD|214599
NZ_AP019860.1|WP_151967114.1|1726404_1727166_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|179371
NZ_AP019860.1|WP_151967118.1|1730957_1733165_-|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013160.1|1722157_1722874_-|transposase	unknown	unknown	gnl|CDD|224854

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967106.1|1715019_1715424_+|response-regulator	gnl|CDD|381113	cd17569, REC_HupR-like, phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains. This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.96669e-18
NZ_AP019860.1|WP_173013159.1|1714366_1715017_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.54285e-37
NZ_AP019860.1|WP_151967113.1|1725784_1726399_-|NYN-domain-containing-protein	gnl|CDD|350236	cd10912, PIN_YacP-like, PIN_domain of Bacillus subtilis YacP/Rae1 and related proteins. Bacillus subtilis YacP, also known as Rae1, is an endoribonuclease involved in ribosome-dependent mRNA decay. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. PIN domains were originally named for their sequence similarity to the N-terminal domain of an annotated pili biogenesis protein, PilT, a domain fusion between a PIN-domain and a PilT ATPase domain. The structural properties of the PIN domain indicate its putative active center, consisting of invariant acidic amino acid residues (putative metal-binding residues), is geometrically similar in the active center of structure-specific 5' nucleases (also known as Flap endonuclease-1-like), PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	4.52109e-16
NZ_AP019860.1|WP_151967112.1|1725372_1725792_-|hotdog-fold-thioesterase	gnl|CDD|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	2.2925e-25
NZ_AP019860.1|WP_151967103.1|1708129_1713508_+|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	4.41357e-172
NZ_AP019860.1|WP_151967110.1|1723284_1724337_-|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.70415e-14
NZ_AP019860.1|WP_151967115.1|1727175_1729029_-|hypothetical-protein	gnl|CDD|226483	COG3975, COG3975, Predicted protease with the C-terminal PDZ domain [General function prediction only].	8.79212e-57
NZ_AP019860.1|WP_173013161.1|1724806_1725358_-|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.08257e-11
NZ_AP019860.1|WP_151967116.1|1729139_1730126_-|histone-deacetylase	gnl|CDD|212518	cd09992, HDAC_classII, Histone deacetylases and histone-like deacetylases, classII. Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.	6.04745e-129
NZ_AP019860.1|WP_173013158.1|1705926_1707759_+|methyltransferase-domain-containing-protein	gnl|CDD|215135	PLN02244, PLN02244, tocopherol O-methyltransferase.	6.16364e-37
NZ_AP019860.1|WP_151967118.1|1730957_1733165_-|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.8665e-108
NZ_AP019860.1|WP_151967104.1|1713526_1714180_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.37587e-62
NZ_AP019860.1|WP_151967107.1|1715620_1720159_+|AAA-family-ATPase	gnl|CDD|226415	COG3899, COG3899, Predicted ATPase [General function prediction only].	2.69325e-83
NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein	gnl|CDD|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	1.42259e-18
NZ_AP019860.1|WP_151967114.1|1726404_1727166_-|MBL-fold-metallo-hydrolase	gnl|CDD|179371	PRK02113, PRK02113, MBL fold metallo-hydrolase.	8.81957e-99
NZ_AP019860.1|WP_173013160.1|1722157_1722874_-|transposase	gnl|CDD|224854	COG1943, COG1943, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.13052e-15

Protein sequences

>NZ_AP019860.1|WP_151967107.1|1715620_1720159_+|AAA-family-ATPase
MKLAETFLNIAADATIYLETEDPLVKDRLIHELDKSFSLLYALSSEIEAPYTKKYVDFVADNHTQNLIALLESDESCLQGVPDNISKWQNQCLVKLSNTYRYWKENIAQGQLRAYFVVAFNNVGLLSSLRMSSYNPLPYQRIQGSGYDTSIARSLDDARKIIKYYWQAKYKLPTSEVDKNLEAWAVEWGSSLLSQFKNRPVTGQSFSFTFTIFFFISSLRKLCEQGVLEVYHHDSHQKIEPHCLNLPSNMVASGAFIRDQIPDESLTPKQYNNIATKKIAHIQTKLEVISQANSVCHEPFIEYFLIPKDNYFDIETQDEKIVIVPIENLDDLITKFFPNWLIRSKYQTSEQPKSHINIEQFVQQGQQLALQLSKIHRQNKIYKHLTLSCITSTLGSSHVDWIPPTEAMSIALVNPKSTMAYIAPEQTDYYNVNIDQRTDIYSLGVIFYQMLTTKLPFSAENVYEFIVAHVSQKVIPPHDLFPQIPPALSRMIMKMLAKNPDDRYKSVAQIAQLLVAYKNNDTLQVTDAYENLVFPRKMYGRKSEYQQLQKSWQNFLDGNNEIVVVYGMPGIGKTDLVNSLLRDVLEQGCFFFTGKYRQNNKQPSYNAWIEILQKFCRQVLSSSPQNVTKWRNMIMDALGTNVSVVAEVVPDFDNLVGKQEPSSPLPPEESRNRFYFVMEQLFDVIVTNSNKITVFIDDIQWTDDASLLLISRFLGKYPQKLFFIFASRNSETSCQKTAHLQELIAAKGIKIKKIFLSPLSLFAVEKILTHLFSPTPNNIRLLSSFIFQKTMGNPLFVKQLLEVLYREKLLYFEKETRTWSWDLSIIEKLNFSNDILDSLRKKTTSLPKEYQDLLQICSCLRENFSTKMLGGIICKYQDCITDFINEATQQHYIVATQSQWNTLSTEHTYKFTHDLVHQSIHASIDEKTKAQIHYDIGSYYFRQDDLSPSKVAVHWNHCIPQLKNEEKKQLAKFNFQAAIRAKNAASYTKAFMYIQHIQKIAQQIKLETKFMSQVSQQEAELAYLSGNFRQAEKLFMQMIANTKDKVEIAQIHAYLVVLYTHIGDWDQSFKVGKKGLSYLGIHWSSRSVLFTLCKEFFRIKRNLRKLKTTPDYFVNVCKLQDKEQEIALQLLSIFMHTTYYGGKLYAFLTALKMVNITIENGFTVDSPNGYAYFAMLLGHLKTLGSYTLGRDFMEWAITLSQKYNNPLHTGRVYFTFGAVVNHWTREFKLNLHYLQKAKKYSIQGGDLMFASYAAVHPLQVYFFSGKNLQELFEETNIRQDFLEKVSFTSQEFFPIGLQKFIVEMSDVSPSRIRKNLTLNYYRNKQQKIKNTTGIIWLETLELKKLYLQNNYQEAVNVATNSLPYIDGAFGQIMQPEYYYYFTLSLLALYSQEKPRKRLNRRIKKNFAKLTTWKNNCSQNFEHKYLIVKCEILRVQHNFVAAMKLYPQAITIAKQNGFIHQQALANELAAKLYIQLGINDTAKMYMQQSIACYEKWGCTMKVQQLSKLLDSVN
>NZ_AP019860.1|WP_151967106.1|1715019_1715424_+|response-regulator
MNIDILIVDDDYLTILYMKEMLMVLGCEVQCANSAQMALEILTKNQIDLIISDVNMPETDGLEFFLQIQKLHPLLADNFILISSNVCEEQMKEIKELQLSLYQKPLSLVTLTKIVAKNFGSDLLEGSKSKFNKL
>NZ_AP019860.1|WP_173013159.1|1714366_1715017_+|response-regulator-transcription-factor
MDTPQAKQIFIVDHPIIQDGLENIFQFENDLKICGRANSSEETLKHLPSVKPDLMIADIFLKGIGGLDFVENIRRAGYTFPILVLSIYEGISYAEQCVGAGIEGYIPKKEKTSTLLKAIRNLLNGQIYIDEDLKLEIIKKFFMSDSLSVFSPKLILTEEEQKVYNFIGDGCPIETIAKLLNLNAKKIILFREQIKKKLYFKDNVELLQSAIGYRKG
>NZ_AP019860.1|WP_151967104.1|1713526_1714180_+|response-regulator
MSSTRVVLIDDHPVVREGLAMSFQQTDDLVVCGEASDYYEALEVIDELQPDVAVMDLSLQGMGGLDLIKTLRKKGHKLPILVLSIHNESFYAERAIRAGAQGYIMKQEKTEEVIKAVRQVLQGKIYVSRELSDSIMYKFFDKNPSSDSPLDRLTDRELEVYQLIGQGVSPHKIADDLCISIKTVDSYRARIKEKLNLKSGTELLQSAIQWVQSQDLG
>NZ_AP019860.1|WP_151967103.1|1708129_1713508_+|AAA-family-ATPase
MLTLQGYKITERIYEGRETEVFKGYKNQQALIFKSLKGEYPSRRALARFRREYEIVKNLDIDGIVEVVDLVEYRNSLVIVLKDFGGVPLSKVIADKKITIDIFFPIAIAIVKILGNIHKHNLIHKDIKPSNIIINYDNLDVKIADFGISTFLSREVPQVRNPKLLEGTLAYMSPEQTGWINRGLDYRTDFYSLGITFYQMLTSRLPFSGKDALELMHAQIAKVAPSPHKIEDIPPSLSLIVDKLMAKTVKERYQSARGLLLDLEDCFSKWRDNEIHLFVPKNAEISERFQLSEKLYGRDKELEILLNSFNEVSKGRMETLLVCGHAGTGKSTLIHEIYKSVLAKKGYFITGKFDQKERNVPYSGFKSAFKKLIVQILGENEEVIYLWRRKLLKAFADNGQVLIDFIPEIELIIGKQPTLEKLPGTESQNRFNVVFINFIRALAQQESPLVIFLDDLQWSDSGTQNLLKLLIDNSLPHLFLLGAYRDNEIDGSHPLAMTLESIEQKHLIKKISLSPLTFPYVNKWIADSLNTSSEKSQSFSQLIFRKTTGNPFFVKQFITTLYQDGILTFDDKTNCWQAPLEEIQQMNVAENVVAFMAEKLSKLPSSSLELIKVAATIGNTFKWQLLATVLEQKITEIKHDVEELVKKGFIFPVGTFDITFVSDEFLEEISFRFAHDKIQQAAYSLIEKEYIKDIHLSIGKIIAQKSPEMIFQLVYHMNLAMDLLSQNEKLQLVEYNLQAGKKAMSSAAYSSACEYFIAGRTLLPENAWENLYPLTLSLHSKAAECEHLNGNFENAKKLFSLSLLHVKSNVERADIYNIKITFHTNLGEHQQALSLGKEGLIFFGIQVPELPGKGTVLQEVLKVKWLLRGKKTEQLLYLPEMVDPNALAAMKLLMSISPSTFFVSPNLWAWGILKMLYLTLKYGNTPISAFVYVCYGIIVGSGSGNYKKGYDFGKLAIEVAEKYGDLRLKTKAFNLFGSLVGHWQQHAIDDIDYLLKAYHTGLECGDLMFACFSLTYVVNKMVITGKNLDEVSQKIKDYSRFFDQLKFQDAVRVYWGIEQMIKSLQDVPENALMQNIEAESTFQEMQTATNQMPLHWHYINQLQVFFIFGRYSQALEMAQKSQEMLSISFGTMQVPVQNFYHSLTLTAIYHKQSHANKRISKKILQENQKKMKKWAKNCPQNFSHKYLLVQAEIARINNDEKEKIIELYEQAIHKADETKYTQNKAIACELAAKFFLAQGKAKIARVYLEEACYSYNKWGAIGKVIDLTRKHTSLLPKKDNSNFTLRSHEIETTISTMVGHLSHLNINTVIKASQAISREISLDKLLVRLMEIALENAGAERGFLILNRDNQLFIEVRQSTDQSKAMLQSIPMDNCAEIPITIVNFVRRTMEKVVLHDAFKEGGFQSDPYVIAKKLKSVLCIPILKQNELLGIFYLENNLTPDVFTPDRLEVLEMISTQSAISIENAKYYEGMKQTQRELQQSETKYRLLMEQASDAILISDKEGNYLDVNSRACEIFGYEKKQFLQLQLSHFFPQRFINLAELESGKTTGAELQMKRGNGTLFPSEFNMKLISDGRIQTIIRDITERKRLEKEVLEISSREQQRVAQDLHDGLGQQLTGIKYLSEALARSLSEKSLDEATKMERISQLVAEAINSTRGMAKGLYPMILQSNGLTVALSELAHNTSKIPRVSCEFNYDSNIEIKDPAVANQLYRIAQEALNNAIKHGGAKNISISLNKENDKNILSVRDNGKGFPEHIKKGMGLNIMKYRAGVLGGDLQIVRKKKNTYVICSF
>NZ_AP019860.1|WP_173013158.1|1705926_1707759_+|methyltransferase-domain-containing-protein
MRLMEQEKFTGINFHPATNEFIYRYYQSLPQIDAFQARSENLFIWTYEGSRQLVLDRVPEISHEVLYNTNVIAVLLNVMIDDIADMILDEKLLHGTLEILETGQDHHGILHSFPEWQMYLSLLMDIRNYLNETIKTWPQYALWISDLVFFIRRLKTAMMGSLYFNQSFHNSKTSNWNFEKYVVEMSPPIHTFIYGIFNLMLIEELEYKEREAIVSALYQGEQFMAMSNWLSTWEVEIEQSDYTSGVVLWALNNNILSKEELNDVPHAKQKIQKSVCISDFAEKMEEKLSIIQGLRSRVSTFSLEKYIEDLREVHDLHMNFNKMLKYQLENEIMLSHEEKRKITEYYSQADKSYQNWGNSVYELHYGYRDHPQDKHHTSLIRMNEEVAQEAKVQKGDRILDAGCGVGASVIWLAKNFDATASGISLSPLQVEKANKFMHEHQLESRVDFSVQDFTKTNFPDNHFDVVWGLESICHAIDKKDFIEEAWRILKPGGRIVVGDTFLVREELSEIEEHALRKWLDGFAIDNLASTKSFIENLENSSFQQIKVRDITENIMGSANEIYQRGKSGYPDDLINKNKSIVQIKHVEACLFQKICLDFGLWRYQIISAQK
>NZ_AP019860.1|WP_151967101.1|1705485_1705710_-|hypothetical-protein
MEVNTMDFMQAYTIANKEGWIVYFDLRLKHWGVGRSLIGDDRICFYPGKSIAELRDLFIVLCEMKGLKNPQMYM
>NZ_AP019860.1|WP_151967100.1|1704100_1705231_-|hypothetical-protein
MSVSVSKEIFYHKTHTCIHCGSIFSYVMKRTPHGMANSEEEAVKAFEANVIQAATGVDNHPCPNCGVVQPEMVAAKRKKHYIWQMIIFTCLFLITVLIAYFHVIHYTTAVLIHFCGAFSIVIWHLITNIHNPNNNLVAQRKIAKQREQHPAQLKLEKQGNLEGDIPPNEITHIYSGFLSALCALSLLFIITPEVVRTTKKWPLNPQWYPQIIGPNDTSRYYFKKAIYSIKGYWRGIAVANIFMEGQSFDAKATTNNNSWEQTISFESSERDTKSHIYAQVTMPSQSQLQNKEVLTVVYIEYKYPKFMGGNTYMIRDGQVEEKTSVKLAHANAGRQYLQLFYGGNVGGGLLLLLLLFVAHQRNKKFLTSTSQATILG
>NZ_AP019860.1|WP_151967099.1|1703893_1704109_+|hypothetical-protein
MDLQNLERAIRFLVYAHGHRLGTSDIAMTMLVSANTIHLTNTYVKLALHVKKIPKNHRAHCHIYFPMTLLP
>NZ_AP019860.1|WP_173013157.1|1702264_1703866_+|hypothetical-protein
MNSIWNLRYHVAIFTLLFASIYIFWQLQKIDLLSSADVVEFVSELKQVDQTLNEEILEIRYFRRDNYNYMTKMVSELEEFPNRVKRSNIQRFLQDKIAFQQNFIQLETTLRKKLALVQNFKNLHGTLHRSLESFPKMVQKHMQEQPSAENELYFLLLKSFVHNFTNSEGAKADVERIVAYANKNNCKPIATMLKSIDQQRQDLDKTLSAILQSPTTTNLNNFFQQYKEYHHEQLRQFSYHKSALIIAFVLFIITLFLLLYSWQNKTQSTKPLTKICQELYDEVGNVGQTSDRLKKTSEWITTNGKQQNSAIQNTNILLREMTQVAQIHWQECAKAQEITDKADSSIRDSINHSHKMILAIKEMEAASYEASTILQNIQEIAKQSKIVGLNATIEAAKSDNEVFELVAQEVSSLAIRSAEALEETSSQILNSQERSRQGTNLTENILLYLSDTQFKIQSLEEKIDKMNAYFQKQKSSFETFGHAVDFVTTSIKKNDEFSQENAQLAENLHSLSSKLKKSVNTMLSISKEMAMKK
>NZ_AP019860.1|WP_173013160.1|1722157_1722874_-|transposase
MRPIRLSMINGLFHITTRCDNKNFYFQEDEDFTEYLKVLEKAREKYGFKLHAYCLTRNHVHLLLSTPTEDNLSTLMQYINGQYAKNYNRRHKRTGHFWGERFYSTIIESETQLLNSIFYIELNMTRNGVTKHPKDWKWSSYNQHSGCKGPIKIDYHEVYLRLSSTAQDRQKKYTSMMEEKMVQKGLLSRQPQVTYGLIFGSESFVKEVIIKCSSHKYYKNRKTYSIDQETYCLRKFKT
>NZ_AP019860.1|WP_151967110.1|1723284_1724337_-|tetratricopeptide-repeat-protein
MRIIIFFLLFSTHILASQLYSKGMAHFFYTYGSHCYSQKNYSEAIQNYSAALKFAPNHCWTLHRLGNCYLVTKKYEKAKNFYLQATNTDNPPLFSYYNLGCIYALQNDKKNALIYLEKTIQKGYTKLEKLEVDSDWSSIRTENKYQQIIQDAKKIKTQHSLIEEYQNSGYQNKMRILQESISKNFPKKLDLAILTLNETYEGYRVASIALLSSLSPKESSEYLIVALFDANGYVKKAAANAIVKSAINVQQQLISILQKPNSPATPYVIQILGHINSTNSIDILIPYLKDEDPFICISTVDSLVRLKAISAIPVLEQISQQMKNAKTPQKEFYQIKIQHAISYLQKLKHK
>NZ_AP019860.1|WP_173013161.1|1724806_1725358_-|FHA-domain-containing-protein
MERIKPCLYDERKNLKFELEFDRDNKIGRGTSPRAKNITISLINESVSSNHATILCRKGNWIFCDESTHGSQVNGKIVHNNTVPIRHKDIIQVGEYSFVFFDEDAISSIGGTQEFSVKGVNLGNSTIEQAMHHLTNSAVERATHHYDQWQQDRRPEVVVIAFACMILFMVLFIGIFFNFFFQL
>NZ_AP019860.1|WP_151967112.1|1725372_1725792_-|hotdog-fold-thioesterase
MSDINKLLDMFNNKAPIAQLFGMKLSFDENNNAKVHLPYNPNLDHALGLVHGGIYATMLDNAGWFTVAAHSETNNFWIATSEMSIHFLLPAKQTSLLATGKIIKYGKRQSIAEMSLFDGNDNLVGHSTGTFIQLSNVSM
>NZ_AP019860.1|WP_151967113.1|1725784_1726399_-|NYN-domain-containing-protein
MIVIIDGYNLLFHDSWPYHEGALEDRRKKLIDLVVSFKQKKRIARVIVVFDGCAGIGPYKKQTSQQGIEIIYAICQGKADEKIISLSKHLNNVMVVTADRRIIKYTKRNRSSITSPQSFTQELLKTQRRTTPKQMSLPTNDVDEWLEEFGLDDEVEIPKNFDEKLPQVPEYTEEQTQEEDDALLDEESVEDWMKWFRFKEGDYE
>NZ_AP019860.1|WP_151967114.1|1726404_1727166_-|MBL-fold-metallo-hydrolase
MKVTFLGTGTSQGVPVPMCDCKVCRSTDHRDQRLRCSVYIEYQGKDIIIDTGPDFRQQLLREKIMHIDGILFTHSHHDHIAGLDDVRCFNFKYKKPIGIYTSAAVEQRLREVFSYIFSEVQYPGAPQVYITRIKDKVFSVKGVEITPLQVLHGKLPIFGFRIGDFTYLTDTSFIPESENEKIQGSKVIVLDALRQTPHPTHLHLDAAIDIIKKFQPQKAYFIHMSHQMGLHDEIEKLLPENMHLAYDGLKIEV
>NZ_AP019860.1|WP_151967115.1|1727175_1729029_-|hypothetical-protein
MRLILALFLATLLSIQAEDYMTLHVDATDLTRGLLTSEMEIHTSDTEIVMWYPKWIPGIHGPRNPVENLGGVYFYSEKGEKLKWHRNSHEPFRFICKLDQDTKKVRIKLRYICNQPNGNSTGVDSYGNSQMGVINWNTVLLYPAWKNNQIKVRTKLTLPKGWKYASALQTKSQEKQTITFKTTTLEELIDCPLICGQYFRTVDLKVNNFPPHYLHLVAESSSDLNIPEKLIQKYRRCVQQAQKIFFKPHFREYHFLVFMSNRLPSMGLEHLSSSLNGIGEKDFFNAWSLKGWVGSLLPHEYVHSWCGKYRRPIGMHTPDYHSNKDTRLLWIYEGLTTYLGEVLAVRSGFLTPEEYIPRFTRKLNYLMKQTGRSWRPLEDTCVCTYTLRQRSKNWGVWRRGQDYYDEGLLLWLEIDTMIRHRSFGEKSLDDFCIQFFGKGNSGQALAFDLLEVYQILDNIVQYDWKNFIEGRIKEPKDKLPLNLVNLCGYRMIYTNKASRYLQELQRRRKYIDASDSLGILFSYDGQIRKIIPGMVGDQSGIAPGMQVTGINGQKFTVSNLENAIANSIVTGKIELLVFERYTYKILTLKYDGGAKYLHLERVPNSPDMLTKILRPVK
>NZ_AP019860.1|WP_151967116.1|1729139_1730126_-|histone-deacetylase
MKTYFITHDTCVKHSAGAGHPENGQRLQAIFDALAEKNIALEKRIAEKVSVDYLPLVHTSAHIEKVLAAHGKKTMFDADTHTNEHSVDAALYAAGAGVEAVDLVLQEPGSTAFCAVRPPGHHAESNRVMGFCLLNSVAIAAAYAIKYKGLQRVLIFDPDVHHGNGTQEIFYHRGDVFYASIHQFPHYPGTGRYEEKGVGDGVGKNANYPLRCGEGDETYIYLAQHAIVDIIKEYKPQLILFSAGFDAHELDPLGGMQVTCQGFCAMYSVIMRHALAEKIPFVYTLEGGYSLNALSSSIHLLLETITTESWPQVSRVIPPEYVKKLLHQ
>NZ_AP019860.1|WP_151967117.1|1730122_1730947_-|hypothetical-protein
MRNRFSYNRVFIPEFFSTVVISIVVTLLTGFWFSKTVHQIDSIHKTPSIVLYTILIIFALYISIYFRSKYSYFVVDSKGLERKGSWYSVPFVGFDQVRTVRESRGEFFGKESRFLYIELKNNEIIRIYDYIFGYDELYAMIEKGIGQKISEDAFLTHGHIHNFANENYANLSQKLKAQSKKRDKVFGDPSNFYDKIVELGRRILCLLPVCATDFYLKIMIDTVFGKNKDVPTVLSFYSSFISLLISIMVARYVYFNLFSYEKGFRYHFKVKKHL
>NZ_AP019860.1|WP_151967118.1|1730957_1733165_-|PQQ-binding-like-beta-propeller-repeat-protein
MSKEHDIYIGQFAVSIGIISAQQLSVCLKLQAQYHQNGEYYSLLDILRHKNFISQSQIHILQKTTTGEGNQTLSANQVPLKIANRYQVLQELGRGGMGIVYRAQDEVFEREVAIKILRNFDGNHKMSARFLREAKAMAKLKHPNIVEIYDIGMEKDFHYFTMEYVKGKNLRTLMQSKKISVREAAKITIKILNALQHAHSNGIIHRDIKPDNIMISDKNVKVMDFGLAKMVEEKVRISQTGNAVGTVHYMSPEQMLAQRSKISYTTDIYSTGVTLYEILTGRTPFVAKSFAEAVKKINRPFTTPHEIKTKIPRQLSAICMKALQKKISKRYQSAEMFLEDLQNFVQSKQNVHAVRHSSRTLPIFGVIILCAICLLTLPLLSNKNKSETVRKVAPQKKTPTILYRGNLRRTGFYNTKPLTNVSQIRWSLPTKKRIKSSPVVSDNIVYFAGYTHKVYALGVQSGKTIWEFTANDLIYSSPAIYDNVLYIGSHDGYMYALEKKNGTLIWKFRAQDSILSSPAFNEGMVYFASHDHKIYAVNARTGKEVWSHKTGDKILSSPAIFDKTLFIGCNDGFLYAIKANSGELRWRFATNGVIKSVPAIDDNAVYFGSFDHHVYAVSHKGELLWRFKTGAEIHSSAAIKELIYVGSNDGYFYALDKNTGKLKWRNATKSPVVMSPCIFNNVLYYSSLDGFLYCAYRRDGRILWRQKLNCTFSSPTIGHNTLFCGGIDGTIYAVD

Crispr_ID: NZ_AP019860_9

• CRISPR_ID: NZ_AP019860_9
• CRISPR_location: 2208782-2208942
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP019860_9

Consensus_repeat	Method
GAATGAACATCATCAATGGTCAT	CRISPRCasFinder

spacers of NZ_AP019860_9

>9.1|2208805|40|NZ_AP019860|CRISPRCasFinder
ATCCCCTGGATCAACTTCGTGTTTTTTCGTTACTATCTGG
>9.2|2208868|52|NZ_AP019860|CRISPRCasFinder
CGCGTCAGTATCTACATATTTTTCCATTTTAGCTTCAGAATTTGCCATTTGT

CRISPR arrays and Neighbor proteins around NZ_AP019860_9

CRISPR arrays

The CRISPR arrays of NZ_AP019860_9

>merge|NZ_AP019860|9|2208782-2208942|CRISPRCasFinder
GAATGAACATCATCAATGGTCATATCCCCTGGATCAACTTCGTGTTTTTTCGTTACTATCTGGGAATGAACATCATCAATGGTCATCGCGTCAGTATCTACATATTTTTCCATTTTAGCTTCAGAATTTGCCATTTGTACGTGAACATCGTCAATGGTCAT

>NZ_AP019860|9|7|2208782-2208942|CRISPRCasFinder
GAATGAACATCATCAATGGTCAT	ATCCCCTGGATCAACTTCGTGTTTTTTCGTTACTATCTGG
GAATGAACATCATCAATGGTCAT	CGCGTCAGTATCTACATATTTTTCCATTTTAGCTTCAGAATTTGCCATTTGT
ACGTGAACATCGTCAATGGTCAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967427.1|2198797_2200468_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967429.1|2201794_2202028_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967434.1|2205236_2206346_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|274033
NZ_AP019860.1|WP_151967435.1|2206410_2208387_-|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|173812
NZ_AP019860.1|WP_151967442.1|2214947_2215988_-|hypothetical-protein	unknown	unknown	gnl|CDD|227292
NZ_AP019860.1|WP_151967445.1|2222667_2223180_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967440.1|2213125_2214139_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967444.1|2218470_2220204_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013192.1|2196596_2198636_-|thioredoxin-domain-containing-protein	unknown	unknown	gnl|CDD|224250
NZ_AP019860.1|WP_151967441.1|2214143_2214944_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NZ_AP019860.1|WP_151967433.1|2204633_2205233_+|hypothetical-protein	unknown	unknown	gnl|CDD|274573
NZ_AP019860.1|WP_151967443.1|2216467_2218393_-|response-regulator	unknown	unknown	gnl|CDD|274362
NZ_AP019860.1|WP_151967428.1|2200926_2201793_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NZ_AP019860.1|WP_151967432.1|2204139_2204631_+|rod-shape-determining-protein-MreD	unknown	unknown	gnl|CDD|274574
NZ_AP019860.1|WP_151967431.1|2203414_2204143_+|hypothetical-protein	unknown	unknown	gnl|CDD|377220
NZ_AP019860.1|WP_151967438.1|2211518_2212229_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|180586
NZ_AP019860.1|WP_151967430.1|2202271_2203315_+|rod-shape-determining-protein-MreB	unknown	unknown	gnl|CDD|237564
NZ_AP019860.1|WP_151967439.1|2212341_2213112_-|twin-arginine-translocase-subunit-TatC	unknown	unknown	gnl|CDD|376413
NZ_AP019860.1|WP_152021976.1|2220334_2222671_+|aminopeptidase	unknown	unknown	gnl|CDD|341067
NZ_AP019860.1|WP_173013193.1|2209808_2211437_-|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl|CDD|226132

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967434.1|2205236_2206346_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	3.81383e-98
NZ_AP019860.1|WP_151967435.1|2206410_2208387_-|S8-family-serine-peptidase	gnl|CDD|173812	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	2.48545e-86
NZ_AP019860.1|WP_151967442.1|2214947_2215988_-|hypothetical-protein	gnl|CDD|227292	COG4956, COG4956, Integral membrane protein (PIN domain superfamily) [General function prediction only].	2.71122e-85
NZ_AP019860.1|WP_173013192.1|2196596_2198636_-|thioredoxin-domain-containing-protein	gnl|CDD|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP019860.1|WP_151967441.1|2214143_2214944_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.43917e-14
NZ_AP019860.1|WP_151967433.1|2204633_2205233_+|hypothetical-protein	gnl|CDD|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	4.5535e-09
NZ_AP019860.1|WP_151967443.1|2216467_2218393_-|response-regulator	gnl|CDD|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	3.10722e-89
NZ_AP019860.1|WP_151967428.1|2200926_2201793_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	5.00441e-09
NZ_AP019860.1|WP_151967432.1|2204139_2204631_+|rod-shape-determining-protein-MreD	gnl|CDD|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0.000315032
NZ_AP019860.1|WP_151967431.1|2203414_2204143_+|hypothetical-protein	gnl|CDD|377220	pfam04085, MreC, rod shape-determining protein MreC. MreC (murein formation C) is involved in the rod shape determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.	5.94886e-23
NZ_AP019860.1|WP_151967438.1|2211518_2212229_+|SDR-family-oxidoreductase	gnl|CDD|180586	PRK06483, PRK06483, dihydromonapterin reductase; Provisional.	6.08403e-86
NZ_AP019860.1|WP_151967430.1|2202271_2203315_+|rod-shape-determining-protein-MreB	gnl|CDD|237564	PRK13930, PRK13930, rod shape-determining protein MreB; Provisional.	2.22436e-173
NZ_AP019860.1|WP_151967439.1|2212341_2213112_-|twin-arginine-translocase-subunit-TatC	gnl|CDD|376413	pfam00902, TatC, Sec-independent protein translocase protein (TatC). The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon.	2.04383e-60
NZ_AP019860.1|WP_152021976.1|2220334_2222671_+|aminopeptidase	gnl|CDD|341067	cd09604, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains bacterial M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	5.60499e-151
NZ_AP019860.1|WP_173013193.1|2209808_2211437_-|sigma-54-interacting-transcriptional-regulator	gnl|CDD|226132	COG3604, FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms].	1.87013e-126

Protein sequences

>NZ_AP019860.1|WP_151967435.1|2206410_2208387_-|S8-family-serine-peptidase
MTKFVILLTIAITFSCSFAGILGPDLQKAMQGDESEFAVMISFTEDVKVGDIMEYYSGMSKEEIFDILKNECEQKQTFIKDLCQRMQLEGYVKDIKVFWLANAVSLTAKREAIEELVMQPEVHLISLDAIQSMIQPFGSLDSAQVPWGLEYIKSREVNAKGFTGQGVTVAVVDTGLDTDHPAFSPQQIRTDLCKSFVPGEPTVEDGNGHGTHCAGTVASQLYGVAPGASLIGVKVLSATGSGSWTAVMEGVQYSALHADVISMSLGGRANPNGNVVEDAVENAIDNGIVVVIAAGNEGPFMQTIGTPGCVKKAITVGAIDNKGELAYFSSRGVSVYLDPKPDMVAPGVDVLSAWKNGGTNTISGTSMATPHVAGLVALMLSKAKGMKPQGVKNILMATTNGTKKENWYGEGTVQCDLAMSKVGTDLGTLEVISERNQNSSTVKIEAVTDSNGKLSVIKTMPANRRALVQRVFCNARYTNFQLSVNGKNGWEKGVGEVEPRTNYDLGQQIVTEKGEVTFKVEAENGPKNSKVKIMISCRHNKLPAEVAPAPQQRVAALARSRTIFFSGRTDREGNLNITQDIVLNSNRLILDMQCNAAYDEYQVTINGEAVWEKPVAELDARTFYPIQKSVNSGSITIKVEGKNGPKNNAKVKFWFRSQ
>NZ_AP019860.1|WP_151967434.1|2205236_2206346_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MSIFNQLKWNKTLYSFIIPIIVIVVLLSIIGLSFIYSTTFDGENTYAKQKKWFIISAIAFFITIRINHKWLLQYAFIFYSLGIITLLFLLICDPFVGNTKRWFRVSSFSIQPSEFMKYALVLVLAKLFSQFVTNKDKTHFDVIPAFFITCLPAAMVFIQPDLGTSLIFFGTLFAMAFVVGIPIRHIILLSLLAFSLIYSYGLKPYQKRRLTNFFQPLVQNELPKYQQEGEMYQLIQSLNAYGSGSWFGSGLKNGYQNINNFLPAKKTDFIFAIVGEEWGFLGTVSTIVLFFALFALLLFTASSLPDLQSQLVVVGITAIFAMQTFVNMFMTVGFAPITGIPLPFISYGGSSLLTSFIGIGLVVSIQGSE
>NZ_AP019860.1|WP_151967433.1|2204633_2205233_+|hypothetical-protein
MESVHNKIMQLIFFSFALSAILCTRLFVLQVVRHDYYLEKTLKQRKKSKNPLYSRKYNIIVEKSAFDIEIIPKKLLNKDKKLAYNESVTRLANLLGYSSGYVWQECLKKEKILRKKIDAKAKEEYEQNGGDWQKIIREKEEMYFNRPYPIFYNIDKNTIMRLAIEKHVPRNNDDILIWRDLYTGFVVRRRAAKQKKRGR
>NZ_AP019860.1|WP_151967432.1|2204139_2204631_+|rod-shape-determining-protein-MreD
MKLYITLIFGVLFLFTGIVVFPILGFHNERPDLLIILCVYIIVYNNSRQSILLQTWLIGLLKDSLTLDLFGLHSLLCILLSYTLLKLKQTMHLTNSFVLLILIFFYTFQYYLLNSIIVYIFCNVDLANTAFKCAIYTTLVAPFTILVLRVFTHEPPEGYLYEV
>NZ_AP019860.1|WP_151967431.1|2203414_2204143_+|hypothetical-protein
MFYSSYFSSWSLTSFTFLLSNPEKKEVKGNKDEIISHLQKQLASKQLEIIHLQQTLANIEALQKEAFLDSSRNLISAKVLLKRDSTSHRNSFVINKGKRDGVQLGALVTFKKNLLGIVSKLSAKSSMVLHVSDPYMHIPVFLMVKKQQAFTIYDEGICVGQSKQKCKIKFIQWFAEKALPEAAVALTSGFGNRYPQGLIVGNVTIKKSTTQREKQHYLLNVNPIALDKIYNVMVTVNQDVRK
>NZ_AP019860.1|WP_151967430.1|2202271_2203315_+|rod-shape-determining-protein-MreB
MLGLSNKILGAVSLNLGIDLGTANTLVSVQNQGIISEPSVVAINKNTNEVLMGGNAVGNEAKKMIGKTPPNIQAVRPLKHGVISDFAVTEAMLRYFIRKALNFKWGIRVRVVIAIPSGINSVEKQAVIDSTRRAGAKEVYLIDEPMAAAIGSGLPITEAKGSMIVDIGGGTSEVAIISLASPVVTRGIKIAGDAMDRAIVDYLKQEKKILIGESTAEIIKKNLGSACELEQELQMEIKGQHATSSLPKTVIVRSEEVREAIQTCIQDIIHMIKNSLEATSPEISADLIERGIVLAGGGALLKGLDQVIANETQLKVSVADSPLECVVRGTGAVLGKLDLLQHILSSP
>NZ_AP019860.1|WP_151967429.1|2201794_2202028_+|hypothetical-protein
MAADYEDYQGELEVIDEGEDLGSSVAPSDSITPVIIILTTIFTIIGMLLIGWELFSVYDGQGNPGRADSALIQIKLK
>NZ_AP019860.1|WP_151967428.1|2200926_2201793_+|hypothetical-protein
MSSIAKIFIFINFILSIAYMVIAGTLLAQKWDYKQMLIDQAQKATREKQVQEDKLKDAEGKVANLQESLNNVTGRAIQLNVELNKTKDIYDEAKRTNDSLNEKIANLEASYKEINSKIGEKDARINELETARDQAKEEKEDAIRAKESSEEEQLVLQTELNNIKGEIAEKEKIIQKQQRELLEAKQIIAAAEKQGVRLDLLYTREKPLDGFITAVSKKLPLVMISLGSDDNVQKGYQFTVFRGSSYIGTIVIEDVYKDASAARILKDKTRQKIQKGDSVTTRFGGTRG
>NZ_AP019860.1|WP_151967427.1|2198797_2200468_+|hypothetical-protein
MQKTILSTSIILLLGSVSVFYAYSSNLYGPFIYDDIWQIVDSEDIENAQYLTANNWRIIPNFTFWLNYNLGPQLEGRNTITTIGGPSLFYWHITNIVLHFACAIALLLLCKDLKFPRALSILVSGVFLVHPLASEAVNYIQARSMILLTLFLLLSIIYRERNILFVLFSLGTILCKEVACFYLLATYIIFSYKKKSQLHKKIPLLGLVCFVIIAFLSPVIYNRFAAGDFFSNLTKQLVAFWYYVKLFIYPAATQLSLDHVTQNFSHGFSSLFALILTGFILCKLNNKVAPRAFLACMVILIPYAFIPTNFVVVEYRAYPFLVFLVVGVASVGLSLYENLVQQARKFYQNQAQKGQNRQSKQKFLYFLAHTTLLCLFVLLLLILSQETRKRSRVWQSAISIYGDTIDKGTLRPSIRFNFCMAYVSTAQWMWENNRQQLARIYFTYGKQHINSYLKEAKKISAQHLLHLRLQLLKVYEIEENFSKILALTTLLKQQVPKHSSHYSLLLLLEAQTYLKQQKSKECETVLLQLKSLKLSKNIQRRYTELLQKLQQLHKQK
>NZ_AP019860.1|WP_173013192.1|2196596_2198636_-|thioredoxin-domain-containing-protein
MQTSKNELAQESSPYLLQHKNNPVHWQPWGEKAFHMAKKRDVPIIVSIGYSTCHWCHVMEHEVFEDQEAAEMMNKWFVCVKVDREERPEVDDIYMSAVHAMNQRGGWPLNVIITPEGKPFFGGTFFPKEQWMKLLKAIHDAWTTERKKVDEIANGLTKFLQENEEQTQSEIPVSIWEDLQKNLRTYYDEKDPAWGRAPKFPSAQMLRLVLLLKEGKEVKQQALDILTTMQDSGLHDLVGGGFHRYSTDKIWRVPHFEKMLYDNALLAVAYFIAGDQYKRNDLTRTGERILDYMLRDLRVKSGEKFIGYACAEDADDPNGEGSFYAWNKELLSQVLSDKEAQALAEDWNVTKGEVHKNDFGHKEPVTSHIPFPRGSSLKEDFHSPESIAKRLSWEQHYAALLKKREERPRPHLDDKVLTSWNGLALSAFAHGARLTQKQKYITATRELASVLLGRHKKDGLLRLPHIAAFINDYGFLLCGLMDAFDALGDVDLVLSAEKIAIEASENFAHKGGGFYSTVDNRDDLIMRSRILYDNAYPSGNSAMALGLVRLWNVTGNEKFKATARASIEVLGKSASKICISLGTLLTAHLALQRGEMTIVITGAGEEKEALLKACRKNHYLATVIDLEKTKKQKWKILEAYKDIRKTTAVFCVGKTCLQPATTEKEIEKLLTEYSKFLRY
>NZ_AP019860.1|WP_173013193.1|2209808_2211437_-|sigma-54-interacting-transcriptional-regulator
MSAKEKLQFLLDTYKSDAHSEKYWNVFCASYEKHGIDYLRRLLSVEKQLFYLQKNLNDINAGFELPTLLQSVLDHAIELTNAERGVLLLNDLEIARNFAQEHIDGDLKISRKLARQVMDHGKAVLTDNAQGDQRFSPYTSVQEHRLVSIICVPLKVRNKNLGAIYLDNRLVMANFEEDELAVLCAFAQQVSLAIENVFLHARMSQRAQQAEEMNIALRDQVKSQTAELTKQIFPVGNYWKICAESEEMQQVFAVIEKVKNSELPVLVCGESGTGKELIAQALHFMGNRKDCSFVSENCAAIPESIFESELFGYEAGAFTGAKKGKKGLFEESHGGTLFLDEIGELPIALQKKLLRTLAEKKIRRVGAHKSIEIDTRIVTATNRDLRQMIREGSFREDLFYRLNVVEIYLPPLRKRRGDIPILIEYFIREYCKTAKMSMRRVSQKVIDMMMSYEWPGNIRQLRNELHRMLTLCDGDLTIDCLSPEIQGRKSTTVTNLPELLREVERNEIEKAMKMCQNNKSKASQVLGISRFSLQRKLEKYQM
>NZ_AP019860.1|WP_151967438.1|2211518_2212229_+|SDR-family-oxidoreductase
MENAIFITGCTRRIGLHLTKRFLDEGYDVIAHYRKMTPELEVYKNRNTVVIRADLTSPKDIDSMVDQLQRYTRSLRAIIHNASFYEKTSDDLSEAIKQYQTFFNVHMLAPFLINHKFYPLLTRGEGPRDIIHITDTNAQNPDKRFCIYSSTKAGLENLTKSFAKNFAPQVKVNSIAPGPIVFSKRESEEQRKAILAKTLLKKEGGMESVFQAVKGIMNNDFITGTCVCVDGGRSLG
>NZ_AP019860.1|WP_151967439.1|2212341_2213112_-|twin-arginine-translocase-subunit-TatC
MDIHDVSMSIGDHLDELRKRIVTCLFVLFGAFAMTIVDQNFYMTIILEPHKEAMLALNHPTTIQVLRYEETFFCYLKVSIIAALIITMPFTLYQLWEFIASGLYSHEKRYVMTFFPFAIIFFATGIVFGYSVLIPLGLRFLGGYGGENTIQMGFTLSSYVSLFFVLTFVCGVIFELPLVMLVLVKAGLLNTRFFVENWRHSFLAAFVIAALLTPPDVVTQLLMAFPIVSLYFSGIFLCSFSDRLQDIRRQINIGIE
>NZ_AP019860.1|WP_151967440.1|2213125_2214139_-|hypothetical-protein
MQKVLHNWWAWLLCIIVVRLVFVAFGEPVLQPSETAIQVLINNVQNDEDASVREAAAQTLRESITAFPQYRQKVMEQLRELAKEKAHGQDIAKLVSSIESDPLYQLSIAVEKPNLPMSFYLEPLLYAIPIIYGLAFVLFFPLFINYVVGHRATLKLYGRGKTVMYMLIFTTWCSSIVIWGFYKEWFIISHILLVVTACIVLFLTVVRKMLMLFLNVQQKVCWVIFVALFCLGGASFIPYTNRSEAPQVKISREKILTAIQSLQQKHYVKAKPLLTKILYNRIYNEPQIIQETLRVLGKIADPDSLHVINAYLSHANVDVRKTATDTTLQIVKKMSQQ
>NZ_AP019860.1|WP_151967441.1|2214143_2214944_-|CPBP-family-intramembrane-metalloprotease
MEKQLIDLLKSPQAIAVFVGIIVAAVWAVSCVLRKIKSQPFEKASWDITDFFVAVCIFFVVLGIAQFFITQEMAGDKYILIVLNGLIQLCTCGFLCLWLRKFRNSSWSSLGIVKLPARKAGYAIAAYLLSWPIFVCIVILSYLLVTSMGETPQKQEIVIYFMNEQGRRLWIGAMVAIVFIPIFEEFFFRAFLYSLLRSFLGVPLAIVGSAICFAAVHGTLVGFLPIASLGVFFALLYERTQAIWIPIAVHSLHNLITILLIIQGIG
>NZ_AP019860.1|WP_151967442.1|2214947_2215988_-|hypothetical-protein
MPGILLVLRTVFVITTASVFYQLAKLIFERPNFHIVNISAIITGSIIGICIIWVEIKYSTRFLVGIFTVILGLLVGFIASYLFVQALFLIPHVNMMKDIFPDEYQKIRDLVNVGITFLFCYLSVAVLYRTKNRFKLLIPFVDFTKEAGDRRLILDSSIIIDGRISNICETGIMKGNLVIPKFILDEVQSLADCSDKQKRIRGRRGLEILAELQKNKKLDVTIEPQTFPNIKEVDNKLIALAQEINGIVITNDYNLKKIAQLQDVGVINLNSLANALKPTVFPGELIDIRIVKQGEEAEQGIGYLEDGTVVIVENTRRMIGKNVSVVVTNVLQNNIGRMVFAKLNES
>NZ_AP019860.1|WP_151967443.1|2216467_2218393_-|response-regulator
MVSREKELEKRIAELELEVLRLKKKTLGKVNGDTIKVPQEFKATFDAAQDTVGEYFQNIEFDPCRALVSVDNERYILMRASSLSFEFLKNIQNLYKDRGPEDALQIGLDFLFDISHVIGIEDAKKFHEQMQVKTPIDKLSAGPVHFAYTGWAFVEILPESNPSPDDNFYLKYHHPYSFEATSWIKAGKKAQKPICIMNAGYSSGWCEASFGIPLTAVEISCRAQGDENCTFIMAPPHRIKEYVHKEEQVRSYHIPVFLDRKEAEEKLKRAKRELEKANEAKSLFLANMSHEIRTPMNAIMGFCDLLQSTKLNKEQQNHLQVIKNSGDLLISLIDDLLDLSMIEFGKFHLQEKVIDVQEIIRKLVQLLQPQFQKKNIEFQFSCGEASKNLLGDPVRIQQIFLNLLNNAIKFTSQNGEISLEISFCETDEHTTMLAVVEDNGIGIPRSEQVKIFEVFSRVDMSFNRTSDGAGLGLAISKYLVERMQGKIRVESEEGKGSKFSFDVKLKKSFDAVLEVPQQKMKRLLNVFVLLVEDDRTNQKIFEIILRRLGCKVDIANNGEEAVEQVQKSEYDIVLMDISMPKMDGLGATRKIRSLGFSMPIIALTAHAMSKEREKGLAIGMNDYICKPVNEQQLFEKIAQYT
>NZ_AP019860.1|WP_151967444.1|2218470_2220204_-|hypothetical-protein
MWRCKAHKCLCYSLLFLITLHADYYKKNVREVPEIWEKVMQKKARLYLHPGGELPGYFDRRMNWYKTKTPLSTKQIRSKKAFIVFRTTGPKVGFMDLKFVKYIFAKNSKWDTYDLAKMLKLSGGEIKFNRNYEPVLQIGPKKVVYLLPRWQVSKLYNIVRDLLLDNSFVTQHAKFARYLERITKQKFTYVDTQMDEEKFFFVLRSINQAYRVFNRPASKSEFSLKVSKRQIQQNSAYSFSLIPFKKGDLDKHADYILQNGIQKGFDKVTLFFPVYYSGGSTRKKRLSRLNNEIVYGHHYFYEDDFAIDEDELLRCLQKIWNSGLSLTFVPHLESIVTLNRIWESNWRIHCEIPLDEHYFLRSYGALLKSIEKNKDNIKLNQQIRITVASEIDPAFVTETQATYKTIERLRRRLAQIGIKNKVKLVWNPNGDFLHGWHEGQKKPNYKLLLKIFENIDSIAPSMYEQHNHIINGSYLESRRSFIRRLVKKLRKMFLGKNIQRLIIRIRKIAKEDFSLGEFGLRDKNSRGNYIDFHREFRKYNKNGCIILWNSGRWDHANITGSNPGKFEEEIQRVLKKP
>NZ_AP019860.1|WP_152021976.1|2220334_2222671_+|aminopeptidase
MQFICLSTLFLFLLSISAQVVNDKYKQADKFRQLDENLRTPNAYRTASGAPGHKYWQQRADYVINVEIDDENQRLIGSEKIAYTNHSPDTLNYIWVQLDNNIFAPNSDAVLTETSGGLQGEIPFALMRRTLARQKFDGSVKITSVKDAFDLPMEYHIVKTMMRIDLKSPLKHGETVSFSISWHYQINDSRLVGGRTSYEYFKEDGNYIYEIAHWYPRMAAYTDVHGWQHKQFLGRGEFTLEFGDFLVRITAPDDHVVASTGVLQNAQEVLTEKQRQRLKEAKTAKKPVFIVTPEEAKLNEKKKPKGKKTWVFKAENVRDFAFATSRKFIWDAQGHNVQGNHVMAMSYYPNEGEPLWSRYSTHSIIHTLNVYSRYTFKYPYPVAISVNGPVFGMEYPMICFNGPRPEKDGTYSKRTKYALISVIIHEVGHNYFPMIVNSDERRWTWMDEGLNTFLQYLSEQEWEDNYPSRRGEPNDITSYMASSAQVPIMTHSDSALQFGPNAYSKPATALNILRETVMGRKLFDKAFKEYSQRWMFKHPTPEDFFRTMEDASGIDLDWFWRGWFYSTDHTDISIEDVRLYNVNTMNPEIEKKLLREKRDSAPETLSKKRNKNLTKRANLYPELKDFYNSYDPLDVTSKELKGFEKFFGGLTEEERKLIETKYNFYSVKFKNIGGLVMPVILQINYSDKTSQELRIPAEIWRYNSEVVSKMIITEKEITSLVLDPRLETADTDLHNNHYPRRIRESRFKLFKRKRPKNPMQVKAEAEKKKAEKKESKGE
>NZ_AP019860.1|WP_151967445.1|2222667_2223180_+|hypothetical-protein
MKKLVVILFLCSTFLFAHRYHFTISEVEWNSQNKCLEVGLRVDSFELESVLSKIYGKKIDLEKTKDVDKILHLYLQKRFLVKTPQRKPCSIVWIGKEISRGQLWLYFEVPVKEPLEGLIISNSVLFEAATFEANSSHTPVNIMNIRYKQHKLSLYFTKDKAQRILSFAKK

Crispr_ID: NZ_AP019860_10

• CRISPR_ID: NZ_AP019860_10
• CRISPR_location: 2358012-2358101
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: RT

Consensus repeat of NZ_AP019860_10

Consensus_repeat	Method
GTGTGACTACCACTACTCACACACT	CRISPRCasFinder

spacers of NZ_AP019860_10

>10.1|2358037|40|NZ_AP019860|CRISPRCasFinder
ACACACACTAGTCACACAATGTGTGTGTGGTGTGACCAAT

CRISPR arrays and Neighbor proteins around NZ_AP019860_10

CRISPR arrays

The CRISPR arrays of NZ_AP019860_10

>merge|NZ_AP019860|10|2358012-2358101|CRISPRCasFinder
GTGTGACTACCACTACTCACACACTACACACACTAGTCACACAATGTGTGTGTGGTGTGACCAATGTGTGACTACCACTACTCACACCTG

>NZ_AP019860|10|8|2358012-2358101|CRISPRCasFinder
GTGTGACTACCACTACTCACACACT	ACACACACTAGTCACACAATGTGTGTGTGGTGTGACCAAT
GTGTGACTACCACTACTCACACCTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967527.1|2345863_2347741_-|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl|CDD|234630
NZ_AP019860.1|WP_151967530.1|2349653_2350718_-|lipopolysaccharide-heptosyltransferase-II	unknown	unknown	gnl|CDD|223928
NZ_AP019860.1|WP_151967539.1|2362098_2363607_-|N-6-DNA-methylase	unknown	unknown	gnl|CDD|223363
NZ_AP019860.1|WP_152021979.1|2359895_2360057_-|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_152021980.1|2366168_2367407_-|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl|CDD|275209
NZ_AP019860.1|WP_151967535.1|2359113_2359302_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967528.1|2347737_2348550_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967541.1|2364214_2365642_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967526.1|2344405_2345851_-|beta-Ala-His-dipeptidase	unknown	unknown	gnl|CDD|349885
NZ_AP019860.1|WP_151967525.1|2342811_2343912_+|serine-hydrolase	unknown	unknown	gnl|CDD|224594
NZ_AP019860.1|WP_173013203.1|2350858_2352019_+|HD-domain-containing-protein	unknown	unknown	gnl|CDD|225971
NZ_AP019860.1|WP_151967536.1|2359377_2359848_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967534.1|2355661_2357935_+|DUF3987-domain-containing-protein	unknown	unknown	gnl|CDD|379041
NZ_AP019860.1|WP_151967532.1|2352021_2353770_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151967542.1|2368216_2369860_-|hypothetical-protein	unknown	unknown	gnl|CDD|225103
NZ_AP019860.1|WP_151967540.1|2363576_2364161_-|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341131
NZ_AP019860.1|WP_151967537.1|2360093_2360339_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967538.1|2360981_2361809_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967533.1|2354203_2355475_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271177
NZ_AP019860.1|WP_151967529.1|2348562_2349657_-|rhomboid-family-intramembrane-serine-protease	unknown	unknown	gnl|CDD|223777

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_AP019860.1|WP_152021980.1|2366168_2367407_-|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	4e-49	161.8	0.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967527.1|2345863_2347741_-|DNA-mismatch-repair-endonuclease-MutL	gnl|CDD|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	0
NZ_AP019860.1|WP_151967530.1|2349653_2350718_-|lipopolysaccharide-heptosyltransferase-II	gnl|CDD|223928	COG0859, RfaF, ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane].	7.11638e-57
NZ_AP019860.1|WP_151967539.1|2362098_2363607_-|N-6-DNA-methylase	gnl|CDD|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	1.5341e-106
NZ_AP019860.1|WP_152021980.1|2366168_2367407_-|group-II-intron-reverse-transcriptase/maturase	gnl|CDD|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	1.75676e-162
NZ_AP019860.1|WP_151967526.1|2344405_2345851_-|beta-Ala-His-dipeptidase	gnl|CDD|349885	cd03890, M20_pepD, M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide. Peptidase M20 family, Peptidase D (PepD, Xaa-His dipeptidase; X-His dipeptidase; aminoacylhistidine dipeptidase; dipeptidase D; Beta-alanyl-histidine dipeptidase; pepD g.p. (Escherichia coli); EC 3.4.13.3) subfamily. PepD is a cytoplasmic enzyme family characterized by its unusual specificity for the dipeptides beta-alanyl-L-histidine (L-carnosine or beta-Ala-His) and gamma-aminobutyryl histidine (L-homocarnosine or gamma-amino-butyl-His). Homocarnosine has been suggested as a precursor for the neurotransmitter gamma-aminobutyric acid (GABA), acting as a GABA reservoir, and may mediate anti-seizure effects of GABAergic therapies. It has also been reported that glucose metabolism could be influenced by L-carnosine. PepD also includes a lid domain that forms a homodimer; however, the physiological function of this extra domain remains unclear.	0
NZ_AP019860.1|WP_151967525.1|2342811_2343912_+|serine-hydrolase	gnl|CDD|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	6.18532e-26
NZ_AP019860.1|WP_173013203.1|2350858_2352019_+|HD-domain-containing-protein	gnl|CDD|225971	COG3437, COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms].	2.50765e-77
NZ_AP019860.1|WP_151967534.1|2355661_2357935_+|DUF3987-domain-containing-protein	gnl|CDD|379041	pfam13148, DUF3987, Protein of unknown function (DUF3987). A family of uncharacterized proteins found by clustering human gut metagenomic sequences.	1.5412e-67
NZ_AP019860.1|WP_151967532.1|2352021_2353770_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.81267e-79
NZ_AP019860.1|WP_151967542.1|2368216_2369860_-|hypothetical-protein	gnl|CDD|225103	COG2192, COG2192, Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones].	8.07116e-87
NZ_AP019860.1|WP_151967540.1|2363576_2364161_-|restriction-endonuclease-subunit-S	gnl|CDD|341131	cd16961, RMtype1_S_TRD-CR_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR) and similar domains. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This superfamily represents a single TRD-CR unit; in addition to type I TRD-CR units, it includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P, as well as TRD-CR-like sequence-recognition domains of the M subunit of putative type I DNA methyltransferase such as M2.CinURNWORF2828P and M.Mae7806ORF3969P.	1.27175e-16
NZ_AP019860.1|WP_151967533.1|2354203_2355475_+|tyrosine-type-recombinase/integrase	gnl|CDD|271177	cd00796, INT_Rci_Hp1_C, Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain. Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	6.09583e-21
NZ_AP019860.1|WP_151967529.1|2348562_2349657_-|rhomboid-family-intramembrane-serine-protease	gnl|CDD|223777	COG0705, COG0705, Membrane associated serine protease [Amino acid transport and metabolism].	1.74389e-35

Protein sequences

>NZ_AP019860.1|WP_151967534.1|2355661_2357935_+|DUF3987-domain-containing-protein
MNIFKEAKQKKLQDYIEYKTGTHFKKVGNSLRADKCPFCENKTAFNIKKELFHCFRCDCKGDIIDFEAKYSCCSRKQACYNILDRQPQQTHTVKSREIHKFIWEKSTPLDEKTAYNWLKNKRNFPTQLANKTKSIVCKRFRLNTYKGTKSIVVPIYSYTQTKIIGIENISLTNSSKKAHGNKKGIFYAHAESKEVIIVESLANALCLASVGISAISIFGVTNSDGIQEIIKNFPNHKLYLWFDKGTENLGEELLLKHREINAIFFEEQKRDKYDVNDLLKESPRDFHHQVQKYIQNAIVSPLQSEQKNLIARNKVPKFPIHVIPEPIQSFCKEVADTVACPVDFVVTPMLTTIGALIGSHKKIQIKNSWQESSAIYTAVVAAPGSGKSPALAKITNLLKKIEEENAAENFQRQKQYVQEKARYDAELQKWKNEVKRGAPADYPPEEPQPFHFIRTHIADATVESISEILANNPRGVILIRDELTAWVKSHNQYKGGNGSDRQFFLSVWAGASCPVDRKGKEPQYITDPFLAITGAIPPKELDTLKKGMQDDGFIDRILFSYPDPTCTTKWSEKEISPTITKKMQQLFLGLYHDNSKKVIDFSPKAKKIWIGWYEFHKAKSIEQEEILQNPLNKMPGQLLRICLILATLSGEDHLTEHTLRGAIEIIEYYKAHLRRSLGILNETETEEKVRKIIDYAKKRNLKSISTKDIYRSRFMKIQKAAPAKELLQWAAEEGIGIFEGHTLHLHDSVFEDFDFSM
>NZ_AP019860.1|WP_151967533.1|2354203_2355475_+|tyrosine-type-recombinase/integrase
MLKKSNTKPIYEEKYNGYRLHFYFDKKQYRYGYIYNQHEAHTIQQEVNKIIRAVKDGLMIPPEDTAIGDFVFSTAFHRYHQEYPQQQAKNLPDVTLGELMQQYLDILITSHKSKKSIDTEKLHLRNLQRFLHSKKLGNPQLKDIDLHFFEQYKQFRYQTVRTDTVNREMDTFRLLFQKAVDNNYINENIARKIKRDQSQIPPGRFRTHKEILRLLQDSSYTKKEIDEIKRYRYLLPKEIEKVINLTKGTWLYPLIVTYAVTGMRRSEALDLQWKNIDMQRQFLEVTSRKQSKTHQETLRTIYFDDAFLEVLRLQKQQAGNSRWVFPNESGNKRRADSVGKKFHRIVKGTEFEGIGLHCFRHSVASNLASKGVDQRMIDSILGHQTEAMRRRYRHLFPEDQKQVLGNWNKSFLVSVNDFKEKVN
>NZ_AP019860.1|WP_151967532.1|2352021_2353770_-|protein-kinase
MTGKQKQYVLKQRYKLEKIIGQGGIGYVYLAKDIHRNQDVAIKQCKHTSDKIVERFKREYKFLCSIKHPNIVMAYDFFEERSNYFLVMEHIPGITLKELLEKEHRLTLLQRLNIALQMCKAVSALNVNKIVHRDIKPDNIIVTEKGIIKLLDLGIAKTTNKELSAITKTGVIIGTPEYISPEQITDKERFNSDVFSIAVVIYQVILGLKESPFLTGSLAGTLNKVVDYELPPIKEKIQDKKYASIYEKISQVLQKALEKESQKRTKSAKELGVQLLQVYRDLQDYDSTHDDIDYEDMGYQATNEYKVTQDAQLAINEVVAKEQKTKRVLIVSQTVSFILIVTLLVFCYILKSKSNFLLSQTSKLEDTVSDLLGQKTLVNNEVFERVTQDNLLSNNRAEMHLIQANHLLDKDEERALKHFDAAIKKHSGYSDAYFGKGLLFQSREDYSLALDFYNKAIAINNTNAYYYSKRGEVHFRLNKYTQALQDYDRAIALDSTNATFFISRAGVYSALSLYEKVVADCNRASKLNKNDPLIYAKRGRAFYLLRSFAKAKSDLQRSLELGIDNKQQVKWLIRQCNKNIKK
>NZ_AP019860.1|WP_173013203.1|2350858_2352019_+|HD-domain-containing-protein
MNVEEKLYKLTQIGIALSRERNLRVLLSKILSEARAFTNAEGGSLYIHRDGKLTFAVSQNDVLYSQQDTVRCKVFRGKTLDIGNNSIAGYSAYTGETINIADAYTIPNDAPYHIDRSFDIENQYRTKSMLVIPMGEKSDELIGVLALINALDNDGKIIPFAQEYEMLIAALASQAAVAIRNAQLNQHLQEAYLDTIMRLSRAAEFRDKETAFHLEKISTYSAILAEQLGFPQKYVDDIRYASPMHDIGKIGISDSILLKPGKLTSEEFEQMKQHTIYGADILKNAKSDVLELSLEIALTHHERYDGLGYPTGLKGKEIPWGGRIVAVADVFDALTSKRCYKDAWETDKAIEYITELAGKQFDPIVVKAFHTSLEKILDAKKTYEES
>NZ_AP019860.1|WP_151967530.1|2349653_2350718_-|lipopolysaccharide-heptosyltransferase-II
MTKDLNIQSIFVQCPTWVGDFIMCTPSVRALRKKYPQAQITLCMAPLMKHLVEGASYYDHLIFYDKKKKHKGVRGLLAFRRELRKNKYDLAVIFPNSIRTGLVAFFTGAKKRIGYERFGKFILLTDTLKRPLENGKKMPVYTGGYYAKLLGLIDATPESLYPELPILPETANTAKEYWQKATNSSSFKMVMTPGAKFGSSKLWPARHWATLIDLLHEKYQANIMMVPGPEDKVITTEIAELAKSSFYIHPPSPEGLTTLKAFIEQADVLVCNDTGPRHIAHAFRTPSVVLMGPNDPRHTETPLENTLVTRNEGLECMPCNLKICPYAHHACMQELSPHKVLANIEKILKKEGKL
>NZ_AP019860.1|WP_151967529.1|2348562_2349657_-|rhomboid-family-intramembrane-serine-protease
MKCPSCKSRMGKHTYHELECYTCIYGCGLWLHQGSKWNFILHDKMKKSSGQFEQSIHKVLHMDCPECHAPLQNIQGGGEYHHINPDVCIHCQGLFISHIEFKWLKKKQQADHRKGETERYFRSRYMICNDTYYEKYEEDREIDIKEYLFSLFTGMPVEINLPPQKTPYVTILFLIANVVFFLALSYTQALQYSVIPQDIKTSHFFTSMFMHAGWLHLLSNMYFLYVFGDNVEDRLGPLKYILLYFICGVVACLTHIFLYSNSSVPFLGASGAVGGLMGGYFHACRKAKIGAVIFFVLIKMHAYDYFIFWMIIQILLSMFNTGIAWDAHLGGFLAGLLLYPVLKNWSMGKNNKFFTLGRPSGKLE
>NZ_AP019860.1|WP_151967528.1|2347737_2348550_-|hypothetical-protein
MEEEICRGTKKKRDLRLDGLKIAGKPAVRDLIILTPHDVAKKSISGKSYFKLEYNLHNDGFMGVKDFENICYFNDKVAAQQKNLSVGSNDVQVMRDHAVLDIKDGELIVRADAFSRVQEDDESNNDITAHIAFKGFRKGSSKEPHVHIEALRIAQKVPINGMMKLQKNDSIGAKKNRHGFRVEYVIRNYGLREAVGIDNLFLLNGKRFFRHPNINLQPGESKLMKLPVYFPIKSGTVTLRADANNKYPKGEECNLELNVKIFFMGFPRTK
>NZ_AP019860.1|WP_151967527.1|2345863_2347741_-|DNA-mismatch-repair-endonuclease-MutL
MSKIKVLPPLLVNQIAAGECIERPASIVKELVENSIDAGATAIEVGVEEAGSRLIRITDNGCGIDREDLPLAITSHATSKLQNADDLLNIRTLGFRGEALASVASVADVFISSCPSGEQSGYKIRSFGGDVKPLEPVAMNHGTIIEVHDLFFNIPARRKFLKKKATEMGHITDTLTKLALSYHKASFKLTHNNKIVFHVEKTATLKERIEQLLAIGECEMLEISYERNGIEVQAFLAPPEVNRANSKQQYVYINGRCIKDRIVLRAVADAYSDYLPMKRHAVAVLFLQMHPEDVDVNVHPTKAEVRYRDSSGIYSAVYHATLEGLRKGDLRPSIPLFSDGPSTSYTTPSTSYTPPPANYYDSQSNQTHSNYYTPGNFVQETMANHMGGSVSTNSYEKIDEMDVPVFENAPMTSTTAMSSRTQPAPQSQNLFSEEEKNVPLRWFQVHDSYIIIETLRGIEVIDQHALHERIIYSKLKQQVAQKQVQSQMLLFPVTVHLTATEMATFSEWQQHLEELGMEMEVVRDDVIIRAIPQMVSDVHAGDLLRDLLEQLERKNKVNISDVIDPIIEMMSCKAAIKAGDNLNPEEVISLIQRREDADNPFHCPHGRPTTLKITLKELEKHFKRT
>NZ_AP019860.1|WP_151967526.1|2344405_2345851_-|beta-Ala-His-dipeptidase
MVDLKTLEPVAVWQHFDEIRQIPRSSKNEEAMRQYVKKVAERNNLSFKEDSIGNVVVSIPATPGKEDVTKVVLQSHLDMVCEKDPDTEHDFEKDAIQVTQKGEYLYAVGTTLGADNGIGVALELAVMEKKDWEHGPIECLFTIDEETGLTGAKELDPSIVTAKTLINLDTEEHRMIYVGCAGGGDTKMSVELEQGAVPENYSSLEVVVSGLKGGHSGCDIHVGKGNAIKILSRILWSFRQDNALQLGSISGGDKHNAIPRNAKATLVVPEDKRQSFIDACNEKFNSIKDEFNEIEPEMSIAVTDSECAQVLTEDASDKVLMLLVTLPHGVLAMNPDIKELVNTSNNLASVRCEEGKCLVLTSTRSSLKEALENVREQIAASGKLIGATVVQDAPYPGWKPDLSSPILQKVKEQYAKTFGEEPEVKAIHAGLECGVIGEKIPGMDMVSIGPQIENPHSPSERVHIGSVDEFWKVFCEILQSV
>NZ_AP019860.1|WP_151967525.1|2342811_2343912_+|serine-hydrolase
MKKKIVLSLIGFLIIALVFFPSCSPKIKYNLPIPMDDTFSQADSNAQSRYQKAALYSQQHNGFAVVVLEGNNVVFEEYQNGSSATTAHHIFSGTKSFSAAMVMAAVQDDILSLDERVADTITEWKTHPQKSQITVRHLLQFTSGVQQNFWRLSYDSFTEKRGVANKYNYALALPCQQTPGSKFEYGSSHQMILGEVMRRKTHRSALAYLNHRIFFPINFRYAGWLHDNYGNPMLPYGCWTTAREWCKFGVLVRDDGAYLGKRILAPGFFRACSTGTKAMPAYGLNFWLNAEVSDEQRQDLIPQLRDNPPGRILCAQAPEDLIVAAGHNGNRLYIVPSRNLVIARLGNSEKDYHDEDFLACIFAGGS
>NZ_AP019860.1|WP_151967535.1|2359113_2359302_+|hypothetical-protein
MSIEQKAKITFGMCDSIRELSRAGIKDRHPEYSKEQIDLALIKLTVGQELFAKAYPNIEIEV
>NZ_AP019860.1|WP_151967536.1|2359377_2359848_+|hypothetical-protein
MANSFYGEPRTTLYIDLIIHPTEEQIHHFIELIGDSAYISEEAAISALQRKSMFNIIDYQTGWKADLIIRKDRDFSITEFERRRKANVFDIEMFIVSPEDSILSKLEWAKKSLSDKQYLDLFSVASIKKDKLDFEYINKWAIELEVSDLLQNSCLI
>NZ_AP019860.1|WP_152021979.1|2359895_2360057_-|PEP-CTERM-sorting-domain-containing-protein
MARAIITPIAPTNGSIFIDTLTVGTAVPETSTYALLSMLVALGFLFRRKRRQH
>NZ_AP019860.1|WP_151967537.1|2360093_2360339_-|hypothetical-protein
MTNEIAGLNFENARVTNDLRGGAFESPENVLVNSDLTNIIVINFDNPVTGVGLFNTSIGDAERFEIFDVQDNLLGSIDLSE
>NZ_AP019860.1|WP_151967538.1|2360981_2361809_-|hypothetical-protein
MEKDNQGTSLSQINEPEFLLTRPFLIFNFLNLNDYLSLDMVVVVQSQTVFFNLKSHISIVWKKMDNDIPDTDIIDKEIEYFFDAYGEGATEELVEQFNEKNVKEFYLRNPYILKNAIIFVNKSKTILHTDPIASLIYSCSATEVFIKQGILKPTIYSSIHHELLSELVTETILKWSIVKLRDLLSKIIEEYKLMDSAFTKFTRDKNKTTLWEERVSIQKIRNNIVHRADPCTIENAKQSYDVANEFFLITKKLLSKIDLDIHKGGIVQSSNNNKV
>NZ_AP019860.1|WP_151967539.1|2362098_2363607_-|N-6-DNA-methylase
MSKNYRTRRLVLTEQKTNEEKINSILWETCSIFREYLNPEEYKNYIITFFFFKYICDVWKDKKKQYEEQFKNDKHCIKKYLEKEKLIIPTDYNYDFIYQKRDSNSIGKIINKVLFEIENRNKVLLDGVFCYLDFNSKKIRNDTLKNLIENFANLDLRPSQIDAEDTIGNVYRSFITRFVSAVGKKGGAFYTPREVSSLLAKLVIPEPGNRICDPACGTASLLLQVANEIEEEVSLYGQEINLNTCALAKMNVYLHGKNALIEQGHTLENPKFIENDNLMKFDIVVSNPPFSIKDWGFEKIKKDKFKRFHRGMPPKSTGDYAFITHIVETITEKNGRAAVLVPHGVLFRGAAEKEIRKKLITENLLSAVIGLPSNLLYGIGIPTAILVITKGKLDSNILFIDASQHYESKKSQHSLRPKDIKKIYWHFIERKTVERYSYLAKFEEIEENEFNLNIRRYVETFQEEKINTKEVQFQIQQIEEELTKTRNQIKTKLDELGKMQKY
>NZ_AP019860.1|WP_151967540.1|2363576_2364161_-|restriction-endonuclease-subunit-S
MERIKLEDIAEINTGYQLRSKVVHDDSGQYTLIQMSNTSNKKLNLTNVLRANLQNVNENHIVRIGDVLFVSKGINNYATVINISLPNNTVAAYHFFRIRIYKKQLIASGYLAWYLNENQAQRYFYKVGEGTNTMMVTRKNLGKLPIPLPSLEKQKKIIELYQLLDKEKELTQNLYEKRKLLATAICQKIIEQGD
>NZ_AP019860.1|WP_151967541.1|2364214_2365642_-|hypothetical-protein
MTVVLKADQQEIIERQLQKLTCFLDGLGLPSDNVIADYQSRQFIGQNLPAYIQSLPNEIVTNARYLSKFVVGAGIGLFDYALNAIWNEVVLSLRKKAIAYGLDIFFDAAVGGNLRATYQSENDLAGLKDIVLLGTCKKLELITETVYKKLAHILDMRNSIGISHPTAQVVNSFELLGWLDTCIKDVLNDCPSESAIQVKAFIENLKNATEIVDNPTLGTIQLKITSLSSTHCCNILTTIFGMFVSNEASQVLRKNISFIAPIVWNCCPDQVKYKLGILLEGYKTNLHSSKHKKGVVFFEKCDGNRYRTPHERIVMLSELTDQLEEKHWELDNFYNEVPIIEKIMSYIKTSTDIPKEISYKMIKVLMLCRIGKGVSYHQGVSPVGKKHYDNFFSFLGENHIPILIKMFTDHAIKYRLDREICRDQAKDFLSIVNENVVMNERMEECLKYLENNIQKNANIVSGNKFKDLSKAIVDW
>NZ_AP019860.1|WP_152021980.1|2366168_2367407_-|group-II-intron-reverse-transcriptase/maturase
MEEICERENLRRALKRVKKNKGSPGIDGMTVEELQGYLCENWLAIRKELMLGNYKTKPVKRVEIPKIGKGLRKLGIPCVLDRFVQQATLQVIQRYWDREFSENSYGFRPKRSAHQAIAKAQKYIEEGNRFVVDIDLEKFFDRVNHDKLMGLLAQRIKDNRVLKLIREFLNAGVMENGLVKPPSEEGTPQGGPLSPLLSNIVLDVLDCELERREHNFVRYADDCNIYVKSRRAGKRVMANLTKFITRKLKLKVNGQKSAVARPWKRKFLGFSFTQHVQPKRRLAHQSIERFKRKIRVITKRTKAKSIEDVIKELSNYLHGWLGYYRFCQTQSILHKMERWMRRRLRCYIWKGWKRGKTRFLELRKRGVGKALAAQTAGSACGVWRLSNSPALNIAFPNSYFEALKLPRLLVIT
>NZ_AP019860.1|WP_151967542.1|2368216_2369860_-|hypothetical-protein
MKPTLAIYGIQDRHNYDCPGYVHDHSLVLMEDGKVITYLHLERLTRRKHDNRMHVYIEDILEEQDFSLPDDFDVVFVDSFVGRSFISSSGKIRFEGPIDKPLATDVELGKCWWKNQERKAYVLNHELAHLYSCLPFYGNFQDNSMLIHFDGGASQDNFSAWLYQNDELKLLEYHWDLSQLSKYFNDNALTFAILGMKHYEHLAVPGKLMGYSCYGKYSPKIHAWLQKNDFFRDIWQDKTSFYHSAEKQFGWGKQQFDLKDTFLQDIAATFQYDFQTQLLSKLTKLQEQHQCEYLYLSGGCALNIIANTMIIDSGLLKEVYIPPCCGDSGLALGAASFVEQKKHKNIKLHSPYLNNFGIKHYNTNYNQETIKKVASLLLENKIIGVCNGYGEIGPRALGNRSLIALPNSIELRDKVSVYHKKREWYRPVAPIILERNAKKITGLSSIQTIAKYMLADFHIREEYKRQIPGVIHTNQSARIQSIASKDENPFMYDLLDYLDQVHKVLCLINTSFNKKGEPIVHTKENAIVSAKSMNIKVVVVNGEIIVL

Crispr_ID: NZ_AP019860_11

• CRISPR_ID: NZ_AP019860_11
• CRISPR_location: 2709169-2709251
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_11

Consensus_repeat	Method
TTGGTGTGCGATGCCCTCACCATC	CRISPRCasFinder

spacers of NZ_AP019860_11

>11.1|2709193|35|NZ_AP019860|CRISPRCasFinder
AAATAGCGCGATTATGATTTTGGTATAGGTATTCG

CRISPR arrays and Neighbor proteins around NZ_AP019860_11

CRISPR arrays

The CRISPR arrays of NZ_AP019860_11

>merge|NZ_AP019860|11|2709169-2709251|CRISPRCasFinder
TTGGTGTGCGATGCCCTCACCATCAAATAGCGCGATTATGATTTTGGTATAGGTATTCGTTGGTGTGCGATGCCCTCACCATC

>NZ_AP019860|11|9|2709169-2709251|CRISPRCasFinder
TTGGTGTGCGATGCCCTCACCATC	AAATAGCGCGATTATGATTTTGGTATAGGTATTCG
TTGGTGTGCGATGCCCTCACCATC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967799.1|2723036_2723804_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223673
NZ_AP019860.1|WP_151967785.1|2703290_2704382_+|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NZ_AP019860.1|WP_151967781.1|2700172_2700559_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967795.1|2715549_2716431_-|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl|CDD|235375
NZ_AP019860.1|WP_173013228.1|2701234_2701963_+|RNA-methyltransferase	unknown	unknown	gnl|CDD|349968
NZ_AP019860.1|WP_151967784.1|2702368_2703208_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
NZ_AP019860.1|WP_151967787.1|2705322_2706054_+|MotA/TolQ/ExbB-proton-channel-family-protein	unknown	unknown	gnl|CDD|223881
NZ_AP019860.1|WP_151967792.1|2712059_2712842_+|polysaccharide-pyruvyl-transferase-family-protein	unknown	unknown	gnl|CDD|377253
NZ_AP019860.1|WP_151967798.1|2720365_2722405_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|239240
NZ_AP019860.1|WP_151967797.1|2718990_2720352_-|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	unknown	unknown	gnl|CDD|274962
NZ_AP019860.1|WP_151967786.1|2704381_2705209_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967790.1|2708021_2709158_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|377314
NZ_AP019860.1|WP_151967788.1|2706037_2706469_+|biopolymer-transporter-ExbD	unknown	unknown	gnl|CDD|376792
NZ_AP019860.1|WP_151967796.1|2716456_2719000_-|polynucleotide-kinase-phosphatase	unknown	unknown	gnl|CDD|274963
NZ_AP019860.1|WP_151967791.1|2709710_2711930_-|hypothetical-protein	unknown	unknown	gnl|CDD|200465
NZ_AP019860.1|WP_151967789.1|2706480_2708028_+|hypothetical-protein	unknown	unknown	gnl|CDD|173412
NZ_AP019860.1|WP_151967794.1|2713768_2715550_-|adenylyl-sulfate-kinase	unknown	unknown	gnl|CDD|225448
NZ_AP019860.1|WP_152021985.1|2722404_2723001_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|183450
NZ_AP019860.1|WP_151967793.1|2712854_2713727_+|Hsp33-family-molecular-chaperone-HslO	unknown	unknown	gnl|CDD|234643
NZ_AP019860.1|WP_151967782.1|2700674_2700983_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967799.1|2723036_2723804_-|ABC-transporter-permease-subunit	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.82708e-52
NZ_AP019860.1|WP_151967785.1|2703290_2704382_+|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.000141793
NZ_AP019860.1|WP_151967790.1|2708021_2709158_+|GNAT-family-N-acetyltransferase	gnl|CDD|377314	pfam04339, FemAB_like, Peptidogalycan biosysnthesis/recognition. FemAB_like is a family of both baterial and Viridiplantae proteins with responsibility for building interpeptide bridges in peptidoglycan. Such a function is feasible for bacteria but less likely for the plant members of this family. Perhaps the plant-members are using homologous proteins to recognize bacterial peptidoglcans as part of their innate immune system.	4.28456e-173
NZ_AP019860.1|WP_151967795.1|2715549_2716431_-|sulfate-adenylyltransferase-subunit-CysD	gnl|CDD|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	5.7195e-139
NZ_AP019860.1|WP_173013228.1|2701234_2701963_+|RNA-methyltransferase	gnl|CDD|349968	cd18095, SpoU-like_rRNA-MTase, SAM-dependent rRNA methylase related to SpoU-TrmH. RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	1.6646e-58
NZ_AP019860.1|WP_151967784.1|2702368_2703208_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.4756e-10
NZ_AP019860.1|WP_151967787.1|2705322_2706054_+|MotA/TolQ/ExbB-proton-channel-family-protein	gnl|CDD|223881	COG0811, TolQ, Biopolymer transport proteins [Intracellular trafficking and secretion].	1.7575e-15
NZ_AP019860.1|WP_151967792.1|2712059_2712842_+|polysaccharide-pyruvyl-transferase-family-protein	gnl|CDD|377253	pfam04230, PS_pyruv_trans, Polysaccharide pyruvyl transferase. Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.	8.90588e-06
NZ_AP019860.1|WP_151967798.1|2720365_2722405_-|FAD-dependent-oxidoreductase	gnl|CDD|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0
NZ_AP019860.1|WP_151967797.1|2718990_2720352_-|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1	gnl|CDD|274962	TIGR04074, Methyltransferase_type_12, 3' terminal RNA ribose 2'-O-methyltransferase Hen1. Members of this protein family are bacterial Hen1, a 3' terminal RNA ribose 2'-O-methyltransferase that acts in bacterial RNA repair. All members of the seed alignment belong to a cassette with the RNA repair enzyme polynucleotide kinase-phosphatase (Pnkp). Chemically similar Hen1 in eukaryotes acts instead on small regulatory RNAs. [Transcription, RNA processing, Protein synthesis, tRNA and rRNA base modification].	0
NZ_AP019860.1|WP_151967794.1|2713768_2715550_-|adenylyl-sulfate-kinase	gnl|CDD|225448	COG2895, CysN, GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism].	2.45136e-135
NZ_AP019860.1|WP_151967788.1|2706037_2706469_+|biopolymer-transporter-ExbD	gnl|CDD|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	7.06048e-17
NZ_AP019860.1|WP_151967796.1|2716456_2719000_-|polynucleotide-kinase-phosphatase	gnl|CDD|274963	TIGR04075, Ser/Thr_phosphatase_family_protein, polynucleotide kinase-phosphatase. Members of this protein family are the bacterial polynucleotide kinase-phosphatase (Pnkp) whose genes occur paired with genes for the 3' terminal RNA ribose 2'-O-methyltransferase Hen1. All members of the seed alignment belong to a cassette with the Hen1. The pair acts in bacterial RNA repair. This enzyme performs end-healing reactions on broken RNA, preparing from the RNA ligase to close the break. The working hypothesis is that the combination of Pnkp (RNA repair) and Hen1 (RNA modification) serves to first repair RNA damage from ribotoxins and then perform a modification that prevents the damage from recurring. [Transcription, RNA processing].	0
NZ_AP019860.1|WP_151967791.1|2709710_2711930_-|hypothetical-protein	gnl|CDD|200465	cd11326, AmyAc_Glg_debranch, Alpha amylase catalytic domain found in glycogen debranching enzymes. Debranching enzymes facilitate the breakdown of glycogen through glucosyltransferase and glucosidase activity. These activities are performed by a single enzyme in mammals, yeast, and some bacteria, but by two distinct enzymes in Escherichia coli and other bacteria. Debranching enzymes perform two activities: 4-alpha-D-glucanotransferase (EC 2.4.1.25) and amylo-1,6-glucosidase (EC 3.2.1.33). 4-alpha-D-glucanotransferase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. Amylo-alpha-1,6-glucosidase catalyzes the endohydrolysis of 1,6-alpha-D-glucoside linkages at points of branching in chains of 1,4-linked alpha-D-glucose residues. In Escherichia coli, GlgX is the debranching enzyme and malQ is the 4-alpha-glucanotransferase. TreX, an archaeal glycogen-debranching enzyme has dual activities like mammals and yeast, but is structurally similar to GlgX. TreX exists in two oligomeric states, a dimer and tetramer. Isoamylase (EC 3.2.1.68) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen and their beta-limit dextrins. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	4.32575e-112
NZ_AP019860.1|WP_151967789.1|2706480_2708028_+|hypothetical-protein	gnl|CDD|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	6.06896e-11
NZ_AP019860.1|WP_152021985.1|2722404_2723001_-|methyltransferase-domain-containing-protein	gnl|CDD|183450	PRK12335, PRK12335, tellurite resistance protein TehB; Provisional.	7.09929e-19
NZ_AP019860.1|WP_151967793.1|2712854_2713727_+|Hsp33-family-molecular-chaperone-HslO	gnl|CDD|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	1.38832e-102

Protein sequences

>NZ_AP019860.1|WP_151967790.1|2708021_2709158_+|GNAT-family-N-acetyltransferase
MVKVKARVIDSITLAQKNEWNALVEASNPFTRYEFLQALETSGSVGGKSGWIPHYIIAKRGSKLVGAIPLYLKFNSLGEYIFDWQWAGLYEQLNMNYFPKFVIAIPFTPATGKRILVHNDEPFEEIAQAMLDLLMREAKRKASSIHWLFITAAESDFLEKHDYIPRLTYQYHWQNNHYESFSHFLQQLKAKKRNQIKRERRVANHVEIEALSGKDLLPIHWDHMYIFYLSTIGKKWAYPYLTRAFFEDIATNFRDNVVLFMAKKEEEYVAGALNFRAGEHMYGRYWGCTEKFYDLHFELCYYQSIEYCINNNIRLYEAGAQGQHKIPRGFLPNYTHSAHWIKEPAFSQVIETIVSEGNRHAQDDIDELNQLSPFRCEN
>NZ_AP019860.1|WP_151967789.1|2706480_2708028_+|hypothetical-protein
MRILHQPNIKYYAIFLAVSGVIHYVLCFLPWEKKKVKVNVAAVVKAAIKKKEEKPQEKPKEKPQKKQVDLQKKKDKEELIRYRENLEKKLRDELINKLKKIEAEKKKEIDEIKKELTKEQIQKRKELEQQTAEQQKISQELMKKLTQINQKMQEIKKQEQQQQREFTKKMQEVERKNEQKMQEKLANLEQKNREKMNEMQKKVNDEQRKLQNRKKQLDMLARKQKEELEKTKEEREQNRKNLEDYKRKIAKAVKNKMREQEKENREKIQKTLDEERKKLALEKTRLEKEILQQKRMLEQAQRLSKKNRRKKEREIINKQWKFLERVRVDSLEEHQKYIRNFSTTSKGDTVVPALNFFDNRFLKDMPEVTRFHKMQLIAYPSSMSYFIKVNLDERSLSRRYVKMKDENYFRKFNERTIDISPEILPKIAREVKRAGVYNYSDGKLNFFMLLPHSTAKYLAWKETTVCKKHGHDPKNVRICNSYFSKTRHGHWSLIVRSLVLKGGRTVSVEDFEERW
>NZ_AP019860.1|WP_151967788.1|2706037_2706469_+|biopolymer-transporter-ExbD
MRKKRRHRQAQEQAGMSTEMMVDVLFILLIFFILISNIKKDSVKIKAAKVDKQKSAGSDKKTKEYVLTIDKKNNIYFNNKKISMKELLASLKKAKKDTPKDHNPVIMLRTDASSSSGNLLEVFLYLDQAGLSDNVQCEIDSKS
>NZ_AP019860.1|WP_151967787.1|2705322_2706054_+|MotA/TolQ/ExbB-proton-channel-family-protein
MLYPYIQEAGLLWMSPIIFLSFIGLAITIERICYWITQKQKSFGRKKKLQQIFADPFSATKVAEICRNTQDNLLLVIGQFVMNYNAMTLELAERKTQMFADKKINESRQFLDILGLISSIAGTLGLMGTVVGISQSFKTLAREDPKGLASSLSTAMYTTIGGIILFLMSYLFLFFFNKISNRFEDDIDENIQRVKDLLEDQEKSQPIIFQEQEVIPSIEEPQPQSIPSSEVVEEKVKIYEKEA
>NZ_AP019860.1|WP_151967786.1|2704381_2705209_+|hypothetical-protein
MRNLFLMMLLVFFVGLSTSWAQEEDLSDVFEEVGLEEDNGATEEKADEKTDEEAMEPYVEEASEENFKEEKDIREFAETLDSDKKSALDSLPKVNEDESKEISRLFEKAAKNYNDILENRPEAEMRTNEERLKANKGLLRDNRDKLATSQSDLRRVKLAYIKRFLILKNSYKRGAFTKETYDLELAKLAKSYEFKIRSLVEDKDYYRGQTKQTAERVKALDELNRINRIMNPKKARAKTAKKKKPLTELEKMMKKVQSTGDWFDVKDVWDAPDRN
>NZ_AP019860.1|WP_151967785.1|2703290_2704382_+|hypothetical-protein
MRYLLNVCLPILLCLSLTSAFAQEDTIREELDRRKRDFEKEKALGKLNNVRSGVIPKQWSIKKEVETIEKSLDSYNPLIESLEEANSDLKTDLANYLKNPNNKVLAAKITHKMSKYAKKIVWNVDKITSSQDVLLSVFTELNRKLNKFNRELEYKNNDLKEQVNRHKKEEKKLNNQLIRLSKQIKSTTDPKEKEKLTRTFRRTYRKFNINARYKQGLSRNQENYESLTKNLGSLVKMFSILHQSFSSLIENLEAEKNYLLDNIRLQADSLHVQRLVHEGITDGSRAVVNVTKKLATLYAQVEGFAKVHEKINRDMARFSDTSRILSAVVDELERAPFQANQPLNDAIDHFAEQEESDDEEENE
>NZ_AP019860.1|WP_151967784.1|2702368_2703208_+|hypothetical-protein
MKHLVLAIIVAFLLTGCTLLNSTNGDATTPQKPLSSVNEHELGKVAYAKGDYSRALQYQTQWLVKYPDDAYAFTERGLVNSKLNKSESAISDFSKATELLPNALRPRIYKCAELAKMGREGEARGLLEQVMSDPNFSQISPYEKFLAYSLDGQFKIKAGLHTDSLPSLNNALRTFNSNTHVFVAKNSPFINRLVVYNRAVVLNKMGDYPRAADDMELYIKISQKAKIRISSKDYARLAIAYYLAEEYDKCRAVLKLVSPKDREMLAQTLEDDMFLDSEY
>NZ_AP019860.1|WP_173013228.1|2701234_2701963_+|RNA-methyltransferase
MKQLHQKKYRRLSQEFLVEGIRICEELIASNYKVQQVYFNEELLKNSRGKKLLDNFQQKNVLATAISREKLAKLSTTTTPSPIIARAKQKRHELALGTSEKFVVLENVSDPGNVGTIIRTAEAFNWDAVILIGESVELYNPKIVRSTMGSLFRQPVFYSSIPNLLSCFEDMGVSYIVTSVDGGSDPKKIEVPTKRAVFLGSEAHGVSSNIEKKAHHKVQIPTQNVESLNIAIAGGILLYLYC
>NZ_AP019860.1|WP_151967782.1|2700674_2700983_-|hypothetical-protein
MYRLLNKHNFDLILLQKTQELVERIRFGQADVVVLDLNSIGCLYSELSNFFEMAEDIPVVILTPYDLCAQEIQNIPQNELCYFMSKPISTKQLEELLTKLLH
>NZ_AP019860.1|WP_151967781.1|2700172_2700559_-|hypothetical-protein
MLFILVCLAACCFKPNKNIQVAGVYAYPEQEDNKEIYELIISLTSSNFFEYTQAARKLIAQGEEALPMLCKYKHLTREVDGINLLVCPPTIKIILQQKSTVWLDEKRQIASQELQKFIEQELKNRTKK
>NZ_AP019860.1|WP_151967791.1|2709710_2711930_-|hypothetical-protein
MTRVLLITLFAIATVCADFANVETAASSEEKYGAHIDAANWVHFVVYSPNAQQVDLLLFSAEKDQKPSQEIPMEKHGDNWKIKVRGQRVGEGLLYMYRAKGAYNVRPGAPFGLSFNDTYYLNDPYSYLNQNVSFSRVFLSIPYGDSDESVYAGGGKSIVYDHRKDTHPGYVKIPHRDLIVYELHVQDYTARIQSLDRQKRGTYLGLATPGLRTPGGLSAGLDHLVELGVNAVELMPVMEYDEETGNLPDRYNHWGYMTTNFFTPEARYASRKGQQVVELKKLIRELHKRKIAVFMDVVYNHTAEQSPWEHKNRLAVKYYNFMGLCNTEIYRSTANGKYYFNNTGTGNDVTFFGGNRFTKRWTNDSLAMWYKVYGVDGFRFDLARILADGSGNAADWVDNDPRFQGAHLHAEPWDLGGQWWNFMDSGGWNYSNNRWTKWLGRYRDHMRRFSASGMKDRSLFKRLIEGRGATSTAGESASSKPWRSINMLTCHDGYTLRDVVYFNDADGSHNCWDSNGDENLRREREKLMMGVLLTSQGVPLILQGDEFGRTKSGAQTQSDAHNTYNYESKNGASYINNVNWIDWNLKDGNTNKSPNGPRYGRELFHWTKNLISLRKKWTHFRRDHFPTYADNSQKGSSNNAKYTYTWENKAFNTPTQLSVVWWGKQGEPDLMLIYNENWEDFTVGNLGDWSQGDWKVLARSWYGEKSDFVNLDNWQQQPNVGGSFTVKARSMAILVSDND
>NZ_AP019860.1|WP_151967792.1|2712059_2712842_+|polysaccharide-pyruvyl-transferase-family-protein
MTKPLKIYWSASLKNGKKNFGDWLSPTICEIITRRRVVWAPPQKCDLAAVGSILQKFTKNRWWRPVKNIWGSGFLEQKSPFCSQHNFHAVRGKYSAQIIRNKDIEILGDPGLLCYLLSTPSPHKKYALGIVPHYKDQENKLVHNFAKNNKHVVVIDILSDPHNFIQRVQECEIILSSSLHGLIVADTFSIPNAWVCLSSLVRGNGFKFYDYYSAFGIETAQPFPFNAQTTLKEIECIPQNYSRQHINTIQQKLLQSFPLL
>NZ_AP019860.1|WP_151967793.1|2712854_2713727_+|Hsp33-family-molecular-chaperone-HslO
MKDDTLVKYISDSNNLRIIAIDASITVDDARIRHRLFPIPAIALGRLLISGILTASTMKEGAMVSLKVQGDGPLGFITVDATYDGHARGYCQNPHFDVENVQNSKISPYIGNGQLKVVKRIDHETDPYTGIVNLYTGEIGEDIAYYFLSSEQIPTAISLGVYYGKDGRVAAAGGILVQALPPQKEEFLAKLETIFAKSPSITDLVLNGADADGIVQAYLPGFDLKRLEAKVPMFKCFCQRSRSEKAIISLGKEQLQTIKEEDGEIDITCDYCGQHYFFSEDDLQKLLDEM
>NZ_AP019860.1|WP_151967794.1|2713768_2715550_-|adenylyl-sulfate-kinase
MERMNIVVVGHVDHGKSTVVGRLLVDTNSLPEGKLEQVKSTCERNAKPFEYAFLLDALKDEQSQGITIDAARIFFKTDKRYYVIIDAPGHIEFLKNMITGASQAEAALLVIDADEGVQENTRRHGYMLSMLGIEQVVVLINKMDLIDYNEEKYNAIVNEYQEFLTKFGLKVDIFIPVSGREGDNIVSSSVKTPWYEGHSVLEVMDLLQKKPHPVDFPMRMMVQDVYKFAAEGDNRRIVSGTIDLGVLHEGDDVVFFPQGKRGRVKSIETFPKKECREATAGQAVGFTLEEQLYVRRGDLVARVADPEPSCSSLILVSLFWLGRKPLEMQKVYTLKYGTAKTQFHIEKINKVMNASNLQQFENQREVTHNSVAECVLKLRQSLAFDTASFSVKTSRFVIVDDYEICGGGIIRETVKDQYSTIRKQALLRNYKWEKSMISSLRRAEKYNQKSTLILITGPKAVGKKTFAKALEAKLFNDGKFVYFLGIGNVLYGVDADIKQKTDVQQEHFRRLGEIANIMLDAGAILLVTAIEVWQKELEILKLLIGSDKIITVWVGDKITTDINFDIEIEVSAIDQSISKVKDYLQERHIIFRV
>NZ_AP019860.1|WP_151967795.1|2715549_2716431_-|sulfate-adenylyltransferase-subunit-CysD
MNYLEQIENKSIHIIREAYSNFKHLAMLWSIGKDSTVLLWLARKAFFGHVPFPLVHIDTNYKIPQMIEYRDQLAMEWKLNLVYGQNEKALAEKQTFPDGNITRIECCSLLKTKALRDTLSGTGKRYKINHSTGQYDVWDNNEPFTGVIVGVRADEEGSRSKERYFSPRNVENNWEISAQPPEFWNQYKTEFAPGTHVRIHPLLDWTELNIWEYIQRENIPTVSLYYDQGEGKRYRSLGCEPCTLAVNSCAKNVDDIVEELKTGKFSNIAERSGRAQDKDDGGGLESLRKDGYM
>NZ_AP019860.1|WP_151967796.1|2716456_2719000_-|polynucleotide-kinase-phosphatase
MEIKIPELSLVILMGAAGSGKSTFAKRLFLNTEVVSSDFCRALVSDDEDCQEANEDAFAVVHEIVRRRLKRGKFTVVDATNLHTQARDPLRALAKKYHFFPVVVALDVSEKTCKTQNEQRERQVAGSVIHRQVRDFKLALKSLKNEGFRLIFKVKENEMSAVKFTRQPLWNNKSHENGPFDIIGDVHGCIDELKTLLGNLGYTIEKNDNKYSVKAPNTRKAVFVGDLVDRGPDSCEVLRLVMDMVAANVAICVPGNHDAKLMRKLKGRNVQLKHGLAETIAQLEKETPQFRERVKEFIFSLVSHYILDNGNLVVAHAGLKENMQGRGSKAVRDFCLYGETTGETDEFGLPIRYNWASEYKGKAMVVYGHTPIPEAEWFNNTLNIDTGCVFGGKLTALRYPEKEIVCVEAAREYSKPIRPIGTGMVTKELTTQQQYDDLLNVEDYLHKQFIETSLRNVTIREGNAAAALEVMTRYALHPKWLIYLPATMSPCETSKDPQYLEHPLEAFDYYRQNNIERVICEEKHMGSRAVIVICKDKETVVKRFGIQEDRLGVCYTRSGRNFFEDEVLEKQFFSRLHAALCASNFWEKFSSNWVCLDCELMPWSVKAQLLLEDQYAAVATASRTATPHVLSALQLAQQRGIDTKNNIEKYQEREKLLEAYAEVYRGYCWPVKSVEDLRLAPFHILATEGCVHSDKDHLWHMQNIAEVCEHDQMLMATKWKTIAVNNEEDVAEGLKWWLDLTASGKEGMVVKPIDFVVHHGKKLLQPAVKCRGREYLRITYGPEYTLSENIVKLKNRALARKRNLALQEFSLGLESLQRFVDGKPLREVHQCVFGILALESEAVDPRL
>NZ_AP019860.1|WP_151967797.1|2718990_2720352_-|3'-terminal-RNA-ribose-2'-O-methyltransferase-Hen1
MLLTISTTRPCATDIGYLFHKHPDKFQTFDFPYGKIHVFYPEAREDKCTLAVLLDINPIDLIRGKKSFAQFALKQYVNDRPYVASSFMSAAISKVLSSAMNGRCEARPELVEEKIPLSVTIPVLPARGAGDLIRKIFAPLDYEIEVQGHLLDEKFPQWGDSDYFTTTLKKVTTLREFLTHLYVLIPVLDNEKHYWVGKSEIDKLLTKGGKWLEEHPERDLILNRYLKYQKNLYFEALENFTEEDIVEAEKGPDDLHTIRLQEVLKEAKKTSARSVVDLGCGEGRMLELLLQEKQFNNILGMDAAARVLQIAEKRLYFEDMAPKQRERISLIQGALTYNDTRIYGYDLALLVEVIEHLDESRLQTFERVLFEFAQPKIVIVTTPNSEYNKLYAKLKDGFRHNDHRFEWTRKEFQQWGEKIANNYQYAVRFKGIGEEHAELGSPGQMGVFTFKWK
>NZ_AP019860.1|WP_151967798.1|2720365_2722405_-|FAD-dependent-oxidoreductase
MTEAVYPHLLSPLDLGFTTIKNRVLMGSMHTGLEETKNGFERMAQYFAERAKGEVGLMVTGGVSPNFVGRAAPFSCQMSSKRHARKHQVVTKAVHEANGKIVMQILHTGRYGFHPFIVAPSKVKSPITPFKPRALSKRGIEKNIRAFVRCASLAKFAGYDGVEIMGSEGYFINQFIAERTNKRSDEWGGSYENRMRLPVEIVKRVREEVGEDFIIIFRLSMLDLVDGGSSKQEVITLGKRIEDAGANIINTGIGWHEARIPTIATMVPRGAFTWVTRTIKEHLSVPVITTNRINTPQVAEEILANGDADMISMARPFLADPYFVKKAMENKSDEINTCIACNQACLDHIFKAKIASCLVNPRACHETEFVEKKATQPKKVAVVGAGPAGLSCAIEASNCGHQVTLYEASGEIGGQFNMAKKIPGKEEFHETIRYFNKQLQLSNVDLQLETRVTAQQLISAKYDVVVLATGVIPRTPNISGIDHEKVLSYIDVLQAQKEVGKTVAIIGAGGIGFDVAEYLSHSPQEKAPSTDVKTYLLRWGIDFEYTKRSGIEGVEKQLESSPREIYLLQRKQKKMGATLGKTTGWAHRINLKEKKVKMLIGVNYEKIDDNGLHIEVEGKKQILAVDNVIICAGQEPFADLQQELLNAKVATHLIGGAHEAKELDAKRAISQGTKLALSF
>NZ_AP019860.1|WP_152021985.1|2722404_2723001_-|methyltransferase-domain-containing-protein
MSCADQTPVEENKDRKKWDKKYSGDTFLYGKDPSPYLKDSLEKLTKGKALDIAAGEGRNAVFLAENGWDVDAVDISAIGLEKAKKLAAEKKCKIHAVVADLTTYKIQENTYDVIVNFYYLQRDLFPQIIAGLKEGGVVVFETFTTDHLQINSKMKREYCLEKNELKNTFAGFEIIEYEEVATSNKAVARLIARKKRKK
>NZ_AP019860.1|WP_151967799.1|2723036_2723804_-|ABC-transporter-permease-subunit
MNNNNNYITVLAPLVVFVLFVIIWHTCVVIFSLPPYLVPSPYRVFGVFRENYAVLLSATFLTAMAAIGGLLLSVVLGTSIALLFSQSKIIRQSLYPYAIFLQTVPIVAIAPLIVVWFGNGFTSVIVVAFIISLFPIITNGTMGLMAVKPQWIDLFVINNASSWQILFKLRFPNAVPYLLTGAKISSGLSVIGAIVGEFFAGYGARYHGLGYLITFTSGQMKTDYLFSAVFMSTILGLVFFGTLSLISNYILRKWE

Crispr_ID: NZ_AP019860_12

• CRISPR_ID: NZ_AP019860_12
• CRISPR_location: 2737599-2738489
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 23 spacers

Consensus repeat of NZ_AP019860_12

Consensus_repeat	Method
TCATTCCNCCACCCATTC	CRT

spacers of NZ_AP019860_12

>12.1|2737617|21|NZ_AP019860|CRT
CGGGGTTGTTTCCTGGAATGG
>12.2|2737656|18|NZ_AP019860|CRT
CCGAGTCGCCGGAAATCG
>12.3|2737692|21|NZ_AP019860|CRT
CTGGATTGTTTCCCGGAATAG
>12.4|2737731|18|NZ_AP019860|CRT
CCGAGTTGCCAGAAATTG
>12.5|2737767|21|NZ_AP019860|CRT
CTGAGTCATTCCCAGGAATAG
>12.6|2737806|18|NZ_AP019860|CRT
CCGAGTCGCCGGAAATCG
>12.7|2737842|18|NZ_AP019860|CRT
CCGAGTCGCCGGAAATCG
>12.8|2737878|18|NZ_AP019860|CRT
CCGAGTCGCCAGAAATTG
>12.9|2737914|21|NZ_AP019860|CRT
CTGAGTCATTTCCAGAAATTG
>12.10|2737953|21|NZ_AP019860|CRT
CTGAGTCGTTACCAGAAATTG
>12.11|2737992|21|NZ_AP019860|CRT
CTGAGTCATTACCAGAAATCG
>12.12|2738031|21|NZ_AP019860|CRT
CTGAGTCGTTACCAGAAATCG
>12.13|2738070|21|NZ_AP019860|CRT
CTGAGTCGTTGCCAGAAATTG
>12.14|2738109|21|NZ_AP019860|CRT
CTGAGTCGTTGCCAGAAATTG
>12.15|2738148|21|NZ_AP019860|CRT
CTGAGTCGTTGCCAGAAATTG
>12.16|2738187|21|NZ_AP019860|CRT
CTGAATCGTTGCCAGAAATTG
>12.17|2738226|18|NZ_AP019860|CRT
CTGAATCGCCAGAAATTG
>12.18|2738262|21|NZ_AP019860|CRT
CTGAGTCGTTACTTGGTATGG
>12.19|2738301|21|NZ_AP019860|CRT
CTGAATCGTTGCCAGAAATCG
>12.20|2738340|18|NZ_AP019860|CRT
CTGAATCGCCAGAAATTG
>12.21|2738376|21|NZ_AP019860|CRT
CCGAATCGTTGCCAGAAATCG
>12.22|2738415|21|NZ_AP019860|CRT
CTGAGTCGTTACTTGGTATGG
>12.23|2738454|18|NZ_AP019860|CRT
CCGAATCGCCAGAGATCG

CRISPR arrays and Neighbor proteins around NZ_AP019860_12

CRISPR arrays

The CRISPR arrays of NZ_AP019860_12

>merge|NZ_AP019860|12|2737599-2738489|CRT
TCATTCCACCACCTGTTACGGGGTTGTTTCCTGGAATGGTCATTCCACCACCCATTCCCGAGTCGCCGGAAATCGTCATTCCACCACCCATTCCTGGATTGTTTCCCGGAATAGTCATTCCACCACCCATTCCCGAGTTGCCAGAAATTGTCATTCCGCCACCCATTCCTGAGTCATTCCCAGGAATAGTCATTCCACCACCCATTCCCGAGTCGCCGGAAATCGTCATTCCACCACCCATTCCCGAGTCGCCGGAAATCGTCATTCCACCACCCATTCCCGAGTCGCCAGAAATTGTCATTCCGCCGCCCATTCCTGAGTCATTTCCAGAAATTGTCATTCCGCCGCCCATTCCTGAGTCGTTACCAGAAATTGTCATTCCGCCGCCCATTCCTGAGTCATTACCAGAAATCGTCATTCCGCCGCCCATTCCTGAGTCGTTACCAGAAATCGTCATTCCGCCACCCATTCCTGAGTCGTTGCCAGAAATTGTCATTCCGCCACCCATTCCTGAGTCGTTGCCAGAAATTGTCATTCCGCCGCCCATTCCTGAGTCGTTGCCAGAAATTGTCATTCCGCCACCCATTCCTGAATCGTTGCCAGAAATTGTCATTCCGCCACCCATTCCTGAATCGCCAGAAATTGTCATTCCGCCACCCATTCCTGAGTCGTTACTTGGTATGGTCATTCCGCCGCCCATTCCTGAATCGTTGCCAGAAATCGTCATTCCGCCACCCATTCCTGAATCGCCAGAAATTGTCATTCCGCCACCCATTCCCGAATCGTTGCCAGAAATCGTCATTCCACCACCCATCCCTGAGTCGTTACTTGGTATGGTCATTCCGCCGCCCATTCCCGAATCGCCAGAGATCGTCATTCCGCCACCCATTC

>NZ_AP019860|12|2|2737599-2738489|CRT
TCATTCCACCACCTGTTA	CGGGGTTGTTTCCTGGAATGG
TCATTCCACCACCCATTC	CCGAGTCGCCGGAAATCG
TCATTCCACCACCCATTC	CTGGATTGTTTCCCGGAATAG
TCATTCCACCACCCATTC	CCGAGTTGCCAGAAATTG
TCATTCCGCCACCCATTC	CTGAGTCATTCCCAGGAATAG
TCATTCCACCACCCATTC	CCGAGTCGCCGGAAATCG
TCATTCCACCACCCATTC	CCGAGTCGCCGGAAATCG
TCATTCCACCACCCATTC	CCGAGTCGCCAGAAATTG
TCATTCCGCCGCCCATTC	CTGAGTCATTTCCAGAAATTG
TCATTCCGCCGCCCATTC	CTGAGTCGTTACCAGAAATTG
TCATTCCGCCGCCCATTC	CTGAGTCATTACCAGAAATCG
TCATTCCGCCGCCCATTC	CTGAGTCGTTACCAGAAATCG
TCATTCCGCCACCCATTC	CTGAGTCGTTGCCAGAAATTG
TCATTCCGCCACCCATTC	CTGAGTCGTTGCCAGAAATTG
TCATTCCGCCGCCCATTC	CTGAGTCGTTGCCAGAAATTG
TCATTCCGCCACCCATTC	CTGAATCGTTGCCAGAAATTG
TCATTCCGCCACCCATTC	CTGAATCGCCAGAAATTG
TCATTCCGCCACCCATTC	CTGAGTCGTTACTTGGTATGG
TCATTCCGCCGCCCATTC	CTGAATCGTTGCCAGAAATCG
TCATTCCGCCACCCATTC	CTGAATCGCCAGAAATTG
TCATTCCGCCACCCATTC	CCGAATCGTTGCCAGAAATCG
TCATTCCACCACCCATCC	CTGAGTCGTTACTTGGTATGG
TCATTCCGCCGCCCATTC	CCGAATCGCCAGAGATCG
TCATTCCGCCACCCATTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967813.1|2741816_2743730_-|homoaconitase	unknown	unknown	gnl|CDD|129245
NZ_AP019860.1|WP_151967808.1|2735738_2736713_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379279
NZ_AP019860.1|WP_151967802.1|2726945_2728013_-|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl|CDD|378924
NZ_AP019860.1|WP_151967800.1|2723796_2724519_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224041
NZ_AP019860.1|WP_151967803.1|2728128_2728977_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293839
NZ_AP019860.1|WP_151967807.1|2734172_2735315_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|238744
NZ_AP019860.1|WP_173013230.1|2758427_2761487_+|amidohydrolase-family-protein	unknown	unknown	gnl|CDD|238634
NZ_AP019860.1|WP_151967811.1|2740324_2741125_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_AP019860.1|WP_151967812.1|2741216_2741774_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967804.1|2728986_2729712_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013229.1|2739686_2740139_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967799.1|2723036_2723804_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|223673
NZ_AP019860.1|WP_151967817.1|2755018_2756602_-|hypothetical-protein	unknown	unknown	gnl|CDD|223914
NZ_AP019860.1|WP_151967815.1|2745948_2754285_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NZ_AP019860.1|WP_151967806.1|2731631_2734160_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|238744
NZ_AP019860.1|WP_151967801.1|2724788_2726942_-|helix-hairpin-helix-domain-containing-protein	unknown	unknown	gnl|CDD|225094
NZ_AP019860.1|WP_151967818.1|2756744_2758055_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151967805.1|2729782_2731642_-|BatD-family-protein	unknown	unknown	gnl|CDD|379280
NZ_AP019860.1|WP_151967814.1|2743739_2745938_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NZ_AP019860.1|WP_151967816.1|2754305_2754998_-|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	unknown	unknown	gnl|CDD|234689

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967813.1|2741816_2743730_-|homoaconitase	gnl|CDD|129245	TIGR00139, Homoaconitase_mitochondrial, homoaconitase. Homoaconitase is known only as a fungal enzyme from two species, where it is part of an unusual lysine biosynthesis pathway. Because this model is based on just two sequences from a narrow taxonomic range, it may not recognize distant orthologs, should any exist. Homoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures, but 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble leuC and leuD over their lengths but are even closer to the respective domains of homoaconitase, and their identity is uncertain. [Amino acid biosynthesis, Aspartate family].	0
NZ_AP019860.1|WP_151967808.1|2735738_2736713_+|ATP-binding-protein	gnl|CDD|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	2.54595e-15
NZ_AP019860.1|WP_151967802.1|2726945_2728013_-|prolyl-oligopeptidase-family-serine-peptidase	gnl|CDD|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	0.000176402
NZ_AP019860.1|WP_151967800.1|2723796_2724519_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	3.36783e-105
NZ_AP019860.1|WP_151967803.1|2728128_2728977_+|MBL-fold-metallo-hydrolase	gnl|CDD|293839	cd16281, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	6.7164e-135
NZ_AP019860.1|WP_151967807.1|2734172_2735315_-|VWA-domain-containing-protein	gnl|CDD|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	3.93762e-51
NZ_AP019860.1|WP_173013230.1|2758427_2761487_+|amidohydrolase-family-protein	gnl|CDD|238634	cd01309, Met_dep_hydrolase_C, Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	3.48907e-127
NZ_AP019860.1|WP_151967811.1|2740324_2741125_+|alpha/beta-fold-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.04935e-35
NZ_AP019860.1|WP_151967799.1|2723036_2723804_-|ABC-transporter-permease-subunit	gnl|CDD|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.82708e-52
NZ_AP019860.1|WP_151967817.1|2755018_2756602_-|hypothetical-protein	gnl|CDD|223914	COG0845, AcrA, Membrane-fusion protein [Cell envelope biogenesis, outer membrane].	1.8091e-07
NZ_AP019860.1|WP_151967815.1|2745948_2754285_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.92524e-14
NZ_AP019860.1|WP_151967806.1|2731631_2734160_-|VWA-domain-containing-protein	gnl|CDD|238744	cd01467, vWA_BatA_type, VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses. In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup are bacterial in origin. They are typified by the presence of a MIDAS motif.	2.04827e-37
NZ_AP019860.1|WP_151967801.1|2724788_2726942_-|helix-hairpin-helix-domain-containing-protein	gnl|CDD|225094	COG2183, Tex, Transcriptional accessory protein [Transcription].	0
NZ_AP019860.1|WP_151967818.1|2756744_2758055_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.84933e-24
NZ_AP019860.1|WP_151967805.1|2729782_2731642_-|BatD-family-protein	gnl|CDD|379280	pfam13584, BatD, Oxygen tolerance. This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.	6.41371e-48
NZ_AP019860.1|WP_151967814.1|2743739_2745938_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	3.46048e-14
NZ_AP019860.1|WP_151967816.1|2754305_2754998_-|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE	gnl|CDD|234689	PRK00216, ubiE, bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE.	1.46428e-97

Protein sequences

>NZ_AP019860.1|WP_151967808.1|2735738_2736713_+|ATP-binding-protein
MASLKIEITRNLTEVVEVTGPLTMGRGKENDIILLDGIVSRHHARVYFDGADVLIEDLNSANGIFVNGDRVFLRALQDKDVMKIGKTKIYFSTEIWDSPPKVIDLMTNDISIFDMNELISAPDIQFKFPSHDEAINQIYEIARQKFELVDELSDLEKINLDAALNEGIGNAQRHGHKYEASLPIEFRYIRKDDRLIMRVTDQGEGFDYRAELRRKKEGNAVDEARKRYQQGGYGGLGIMLMLKCVHKVEYNRKGNQVTLTKFLGEAAKKFEQEQQEEINEDKKQEAAEAAEAGSNDMGLQGFVVSGDDDDTTQGKEGGFVIQPD
>NZ_AP019860.1|WP_151967807.1|2734172_2735315_-|VWA-domain-containing-protein
MFYHTKMMGNFILFACVICVFLYVTQLFLPNMTWNDPLYFLLFILLPIFILKWSFPRKSTAIKFSSIRNLKNIRPSWRVRVYFLLPFLKALGFCLLIMALARPQVGNDNTKITSEGIAIMMVVDVSSSMRALDFATREKRQNRLDVVKEVFHRFVLGSDNMRGRNNDLIGIVAFGGYPESKCPLTLDHNAVVSILQTQVKIPEPIFDSNQQLLNAEEFQTAIGDAMIIGTERLKNSSAKSKVMLLLTDGENTAGVSDPLESAKIARDFGVKVYTIGVGTNERVPYPVENAFGEEVLRSAHFPMNEEVLQKIAKTTKGKYFNARNKSALYDIYSEIDTLEKQEIKVTYLQYDELYLWFLIPGVLFILLEKLLANTVLRKMP
>NZ_AP019860.1|WP_151967806.1|2731631_2734160_-|VWA-domain-containing-protein
MDFVNKIFLAFLCAIPIIFFLLFLSYRSRDKAMQKFASDEMLKKIVPGSDWGIRIWKMLLFSCGIALIILAIARPKWGLYFQNVQNYGRDVVVLLDLSKSMLAEDVQPTRLERAKKDIEDLVNALKGDRIALVAFAGRVETRCPLTLDYNFFKWALDECHPGVVALGGTAIGDAIREGVNLFDKEDVQQENSRRTKAILLITDGEDHETAPLEAAKLARKNNVTIFTVGFGDDKQGARIPVTTNDGRKEYLRDNEGRIVWSRLNDQLLRQISLATKGGVYFPVKTRNINMVNVYSDYIAQMDAKIHQSAKKPQKRDRFQIFVLLGLIVLLLESLVMEGSLRTKVAIVMMCVVLCGCSGENDEAYSLNQEAHKLYHSGEYTKAKEKFQEAEVASPENSTVLYNIANTMYKQKKWKEAKDYYQQSAYNTNNNDKQLFRIAFNEGCTYFREAQELMAKNSAKMQDVVSLLQQSLRHFRKALQYKNDDTGTLHNLRFVKLVLKSYLDKLHKKQQEEQKKQETMQTLLALLRRNQIMMNYQSKVFVREKHSLKDLAPQQKKQMEVFDKLEKKLQEKMKAVKDENQANMFKMQMQMLRASLSQLAEKMQDNDATVVQDQETFLRSLDPFWELLASADLVITEDILLQTLVVNDLQSEAQKFPKLVKTADDHQALAILSTTLFEKKFAELMKSIAEQKKQLQQKQNSQQKNPQGHSDPKLPKIDEKEIKRLTKQAMTEQAQAKKSLENNEQSPAQEQARKALETLQKIAEKLGAQKQQNPQQQKKKQQQKKKQQQKKKQEQKQQQKKKQQKMSKKQAEKMLQKIKKRMKDNKERKRQSGNNSIGVENDW
>NZ_AP019860.1|WP_151967805.1|2729782_2731642_-|BatD-family-protein
MIGKKLVVCMALICLVLIFGEREVSAKIQLAKEDIFFGERTELYVLVSGGGRDSIIDTQSLSEDFSIYRVTDQSRNSESVSIINGQVTRTVFRGHVFVYSLQPKRAGTFTVGPISVTVDGTTIRSNRVVLSVSGTETGNNIFVKTSSPLLQYVVGEVFSISADVYIKGSAQNNNEPVFVSKPPHVSIPWLSNDYKGLETDNWQKVFSARIVKPERIGFYINNIQLQDSVFSMFESENAKFSFDKEFVTTTAPTGEKAAYVKYSIARQFEAKKTGKYTFGGINLQGTIGLPGGARKRVRVAGDSVTIEVVELPMEERPEYFDGAIGDYNIEAKLLSTKANVGDLLDLVVTVRGSGKLDNVLAPKLGMQPQINENYKVYEDNVNVESSSTSKKFQYSVRARRATKVFPPIFFSFFDSKTRKYKTISSTEIPLEIKEVQALSPNEIVKSVEAKKQKTVAGQDEGIFANYEGLDALKNQSLGMQMWQTITMLAMPVIYVFLCIVMLYHKKWGSDVAFQRKRKALARAKQRLQAAKDLKDEQLYAAKLDAIRGYVADRFNLNEQALVSGELLGMLKKELSAESYGRLQSFLELCESVRYGVVESSTDIAKITSELLNALHVELS
>NZ_AP019860.1|WP_151967804.1|2728986_2729712_+|hypothetical-protein
MPLVISILCCLQIIGGISLIIVAAYSYRTLQFSVEKINLIAQKLSQKMNEKYEKGEPVTNKKPLSKDEMDKINGYLEYLGDNVKLQITMSFLSLYFIGSKITSRPVVPLFSTFIFAIVNICCGFMLLYGGEEGWYLGICACIYALLRNLHALALLPKLTKTLSHTIFKVNQFYIKYAVRSCVLVLLIFYFFSSEIMHYFSMEQTTIDILILVETAAIGFVGLDFLCYKMQEWTMEPANGEY
>NZ_AP019860.1|WP_151967803.1|2728128_2728977_+|MBL-fold-metallo-hydrolase
MQIANYQLHIVETGRFGLDGGAMFGVVPKVLWNRTNPADEKNRISLAMRTLLLVGEGRVILIDTGVGDYWPQKFCNIYAIDHDHSSLVQSLEKLGYTPNDVTDVIVTHLHFDHVGGAVRLEGQQHVPLFSNAKYHIQKSNLQHAKNPLEKDRASYLPETFMPLVENNLVEVTDGEKELLPNIHVLPVDGHTIGQQMVKISDNSDTLLYCADLIPTSSHIPIPYVMAYDLSPVKTIEEKKKYLQLACDNNWLLYFEHDPQIATVTVTKNTKGFIADKTMSNFS
>NZ_AP019860.1|WP_151967802.1|2726945_2728013_-|prolyl-oligopeptidase-family-serine-peptidase
MLKVIKYLFLVLLMPLAGCTTTRYNYDPTNTIRTQSVPRELLQSITIEKETLRFEEKKIASECDYDLYDVSIFKDNTVITSLRWYRSKRAKKNPRPVDFIWPILAGKKMIVANLYAANIFAPIGVDSIIIRQNGKLFKTNPPRMPKDFIDFNQETVRSLLRARRWAEQKSFFDKKRFGITGTSYGGILATVCIPFTRDFASHKIIMAGGGIPEILNSSVEVRVVRWRKALLQQIAQKIRDERTPQLQADYYNNLDAYEKKITEDAFVEMQERFQKIEKWDPFHFAQYAEPETTAMIVTLCDNHVPSANQKRLWKKLGRPETLFVNSGHFTLALAYFQVKSFLKEMATKHYGLDRS
>NZ_AP019860.1|WP_151967801.1|2724788_2726942_-|helix-hairpin-helix-domain-containing-protein
MQDIIIKRICDHLTIPSKKVEGTIALLDEGNTIPFITRYRKEATGGLDEQQIQDISDQLERERSLEKRKQEVTEKIKEQGKLTTELEHKISEASQLKTLEDIYLPFRPKRRTRALIAKEKGLEPFAMQILHYDTDNPQQQAREYINPQQELDDIEQVLGGAMDIIAEVVAENSDVREIVRNYTGNTGTISVAKTSKGEDPDQIYKDYYEYEEKVTTIPAHRILAIDRGENAKVLRIKVEVDDELICQRIARRYTKKQHAACTQYIEEAVTDGYKRLIAPAISREIRSELTDKAHQHAIDIFAQNLRNLLMQAPLQDMCLLAIDPGYVSGCKLAVISATGELLDYAAVFPHQPQRQMDKAQKTILSMCEKHDVNAIVIGNGTACRETEELVAEIIAASPLKLVYTIVSEAGASVYSASKEAREEFPDLDASYRGTISIGRRVLDPLAELVKIDPKSLGVGLYQHDVNGKKLDQALERIVASCVNYVGVDLNRASSELLSHVAGINSRIAKNIVQKRKELGRFTSRKDLKNVSGIGSGTFTQCAGFLRIQNSREPLDETAIHPESYKVCEKLFDVMGCEKKQLHHKEVNQKLQDLDVTKIASQLDVGVPTMKDIFENLMRPGRDPREELPKPIFRSGVLSLEDLEPGMELKGTVRNVIDFGAFVDIGVKVDGLVHISQMSRSYVKNPMDICKIGDNIDVKILSVDTGRKRISLSMVLGD
>NZ_AP019860.1|WP_151967800.1|2723796_2724519_-|ATP-binding-cassette-domain-containing-protein
MYYENNVQALQDIDFCVTQGEFVSIVGPSGCGKSTLIRIIAGLIDNYVGDVRVAEMTKTDEQPLALVFQEANLLPWRKTLDNVRLPLELAEVCENVQKEKSLAALDIVRLKDFAHAYPRELSGGMKMRVSLARALVTKPQLMLLDEPFSALDEITRQQLNEDLLRLWQQDQWTALFVTHNISEAVFLSSRIIVMSDRPGRIIADVAIPFSYPRTPQLRSSVEFAQHVGKISSLLREGTYE
>NZ_AP019860.1|WP_151967799.1|2723036_2723804_-|ABC-transporter-permease-subunit
MNNNNNYITVLAPLVVFVLFVIIWHTCVVIFSLPPYLVPSPYRVFGVFRENYAVLLSATFLTAMAAIGGLLLSVVLGTSIALLFSQSKIIRQSLYPYAIFLQTVPIVAIAPLIVVWFGNGFTSVIVVAFIISLFPIITNGTMGLMAVKPQWIDLFVINNASSWQILFKLRFPNAVPYLLTGAKISSGLSVIGAIVGEFFAGYGARYHGLGYLITFTSGQMKTDYLFSAVFMSTILGLVFFGTLSLISNYILRKWE
>NZ_AP019860.1|WP_173013229.1|2739686_2740139_-|hypothetical-protein
MRRTPTNRVYQFCKRKSMKKTFFRCAAYLAIICSIICCQSTQKNYVKENPEMDAKKKLAIKTGQVINGMTEKEVEIILGKPTFVEKREGEQQRWIYRLVEKGKNLAEVYTPESSFPQGIAYIIPFYYRPLEIRVDICDKVVCRVEEILSF
>NZ_AP019860.1|WP_151967811.1|2740324_2741125_+|alpha/beta-fold-hydrolase
MLSRKNMSQKGLQYYVQGESDPHVVFIHGLFGCGRNWHSYLRYVNEQFSLSCCAPDLRGQGDSQHFSCPGTIESLVEDIYDFLSELNLSKKPIVIGHSLGAKIAIVLAAKYPQLTEKIMVVDTALPPIGREVFTILEWLNGLKTPVQERREARSYFDDLTQDQRLRNFLLTNLVKGEKGYQWRLDLQGLHGVVTSLTTMDLEPYWLKINVPICLVRGADSTHLTAEQAQQMRSLRDVDFVEIENAEHWVHADNPVAFRECLRNFLV
>NZ_AP019860.1|WP_151967812.1|2741216_2741774_-|hypothetical-protein
MKKWAIVLMAFAVNFVLADTIDAKLADQLHNEVIKMKNALDKGNYKHVADVTHPKIVKLFKGKENLILTTEKAMEQKAKSGFTLSYTFQKPTKIYTHKQEYIVFVPLKMVTENSDMEIILDGFMIASSKDKKKWFLCNSGSSEKEAKQLLSFLFPGFLETKTKDGKAAVKLPKVQQMAKFKDVVK
>NZ_AP019860.1|WP_151967813.1|2741816_2743730_-|homoaconitase
MQNLTEKIAQNFAIDVHGEVHSGDYVQIRPLHVMTHDNTGAVIPKFTNMKFPKVASPQQVVCALDHNIQDQSIQNQQKYQKIESFCRKHNIDFYRAGKGIGHQIMCEEGYAWPNTFVVASDSHTNMYGGLGCLGTPVVRTDAAVIWGTTQTWWQIPPVAKVELIGEMPPGVSGKDIIIALCGHFHQDEVLNHAVEFCGEGIAQLAIHDRLTIANMTTEWGALSGLFPVDKYTIAWLRERAERVKHKKHPRISHQRIDELQENIMLADRGATYHKHLQLDLASISPHVSGPNSVKVMTSISEIEKRNIKIDKAYLVSCVNSRVEDLAQAAAILKNQKVHSDIKFYVSAASAEVQQESSQRGDWQILTDAGAIVLPPGCGPCIGLGQGILEENETAISATNRNFKGRMGARSADVYLSSPAVVAASAIAGKIVSPQQMKFAKDIRATIETTSTQQPRRGEWNEAFMKKWHANVVLCLEDNINTDGIYPGKYTYNDGLSPQEQAAVVMENYDTRFTQIAQSGDILIAGFNFGTGSSREQAATALKYFGIRMVIAGSFSQTFKRNAINNGFLIIETPQLVRDLQQDYHTLPTVRLDKKIEVDFANSVVTLNDEKYPLEYFQKIIQELIVADGIQNWVVNRG
>NZ_AP019860.1|WP_151967814.1|2743739_2745938_-|tetratricopeptide-repeat-protein
MSELEILPVVLKQIHETSQSGTLMVETDEEEIFIYLKDGMIRSLAFAHGKSILAESLRNFDKINKETLRSIFFKQREMITSLLDALRNCESVPDEFKDVGFLADICRKQIEEELYEVLNWENIKCEFMQNELSEEIFDLDLVNLPINIKFEAILMEAARRADEWELIQEIIPSTKDIPAKITDSIDNDDGDSKRIFEKVDGKQNIDEILISVRLTNFQGMKIMSDLIKNEQIRLKTVEEIAQMTRLDSIRNDGEKCISIYELLESKGYKNYETISWLARAYDKKGLTAKAAVKYNEQGQIAFDKDRYEEAIKAYNKVVNFSPDNLEAYEKLIHCYYKSSLLEKAAEISAVYARKISVKDKRKAIMVLDEANKNYPSSSSNLELMASLYIEMGDKENAISVYYILAMLMNKQKKPELALSAYRKILAINPNDFHAQIELGDGLIKLGKHNEAVDQYKNLGKSIYSEMKNESSNDRGSEDALIEVCKWIIKYEPESIIARDWLCEAYIHKKKIDEAIKALKENIDLLKKLDDKDSLVAHLRKLIKLDPDDFNNRKLLSSILFQMERRSESISELIDLGTHFYDKSDLRKAREAFESLLSIDPFNLHARHCHANILRQLHRHARAVEEYRLVGYLAKSLGMHKEAIEAFSKVIELAPGTERAQYMEIAHLYECLGEYEEAVNYYYTYAKKSLTHGNYGEVRHICSRIQELKPQHEGARALREQAEAKLELMPRLI
>NZ_AP019860.1|WP_151967815.1|2745948_2754285_-|tetratricopeptide-repeat-protein
MDDLVKKFAEMPHDTQMFEKLVHKYTREEDWNALIHLHIDHAQAIKDETKGEAYRYFLQAARLQKIHRAFSSETIDLLQTCMNLLPERDDAFLEMEIHYQNEKKWEELIGIYKQKIEHSSVVAQEELATNIANIYFFELKDLTNAACFYEKAATVNPQSKTIQFHLLDIYEKQQQYEKYYHVLEILINLSDTVEEKERYYFQLAELQFEQNKWEKAAQSYQKITGTPYRERIISRLEEIYKDDPDHLITVLNQKLDFLKAKEEKAKTYLQLARLKDEHFSELDNAIVFYEKALLLKSDINIIESICDVLWRKENIHEWYLYKKQKVAMLASKQEKAYTLHSCAVDLKASKQNEENIDRLVEIYENILQLSPGDEIAIEYLTQTYQALHRYEQLVKVLVHKSKYSSLAERVSIYYNIAKLLPESLSQQQGSYYQKVIAIQGDHNEALLQLRNKYTESKNYRELIKVIEDEIRLTAIDPEIRYHEIGTIYDEHLEDEDNAIAYFEKALASNSLFLPSYVSLRRLHKKRGEIEKYIEVGEKELTVNENKQESIDLHFSLAEMYVDRDREKQERHLRKILHYEPDETKANDILLRNYEEKGDWQKYVGILLNKAAFQPYSEDVAALYQQIATVYEEQLKDIPTAKLYYVKAHYLQPTQLDIMCKLSKICADLQQVTEQIVYLKKEMALTKDCKEVAAIQRKIADIYVQENDIDAALTYYKKATANVPDDLEILKTLEKLYSDHNRTSLLIANLNEQTFLVDDASKIDLYKRLADLSDNTDDKILYLQKLQQLDFSSAYVSLEECYRIKEMWTELSALYAKKLEEKEQLEILQKAANVYEEHIEDNYKLQRLYIKILAKTSDDTIFEKLERISYKIEDWEKVVEICQAKLKKTNDSEQIFLQMGEIYTKHIPDVDAAISHYYKALDLNLQTTTLQKLKSLHLVKLEYHKAIEIIDKLIDVTGGEHDLYIELGNIFYQHLREEDKAIIHYQKALEVDDESLHAIECLEKVCLCNKNYQLLIEILDKKQQLKDDPEIGLQIANIWQNFLNEINKAVVILEELSQKYPENIRIKEKLSSIYREQEDWQKLIAVYDERRKLAKSDAVQAQFLFLQGKIYEEELHDQKTAAEIYVKILTIIPGHLPTIKSLQRVYQKERNIAALTESYLAELAIADISRKRKEALHIFCAELFEKNLNEKDWAITHYLQVLKIDANNLVAIRGLQNLYRERKQYEKLVHVLIAELSIEKNARRLFLVEKELGEISLLQFENYNDAIVYYMKAHETLPEKHEVLARLQKLLRNEERWEEYTRYVEEELQYLSPKEKKKTTLELVDVYDKELSNKEKAIVHLESMLDEFGADTVILQHLQQLYGDNYEVDKLIDVLEKKLSFTSDNDAQVNLHFKIGSLLLKKLKEVDKAAVHFQKALELNPESKKIFNVLAKLYTKERNWLKLIELYSLRVRYVKGVEKEREFFYKMGTIFEKKLQRIDEAIKYYELALTVQSQDGGFAPALRSIRKLCEAKKDWTRVIEYLLAEVQHVKTAKERAALYFKIARIWEQKLGHPHQGVKYYLKVIDNHYHEPTAKHAIGLLKGIKNYTALCALLEQMIERCANEQKIYLLGELGNILFAEEHKITEAIAIYREILLLDSNNLQALNALETIYEKQRDWLEVTEIKRKKLEFTKQKNAICHLHIDLGRIYEHYLFEEKQAIHHYEQALKIQSQDVNLLHTLQNLYKNWGYFQEYLDLCHKEIFIINDNPRKIYLWSEMAIIWENRLFENNAAIICYKEILKIDSGNNNAIVALIRLYNYIEDYENLVDIYKLQISLALKANITGEILPLQLTTANILYHRLHRLDEAEEMYNKVLEISPENEKALEALRDLYKRKDDIEGQGQILEKAILLEKNRTKLAELYQQLGKVYEGDNRFEVKAAEAYEKAFEIENDAAILRILQKLYRDLHNDELLIGTNRRLLQTELSNKEQADLHFEMGCILHKKSLEKAVEEFQKVVEILPSHKKNLETLCQCWRETQNWSEFIAVMEQRISQESNRGVISLLYFEIGQVYAQQLENVDEAKNCYEKSIDYDRQNVQAIYHLADIFYEFQHWVAAQSLYQRLTHYPQKEVALEDIYYILGKISEKLSDTDTAILRYQKSVEYKADFALSLDHLANLYYDNAQWDEALLYYMKLENTPSRHAEIDMMNISLRLAIIKDKMGMTEGAIDGYLQHLKENRDQKQVLEGLARLHMEKGEWDTSIEYYEKLLQIEDSHQTLLKIAEVHEKNENWRECQLIYDKLCTEFPNNNDFFEKYITLSCKMQDWENAQSYVEKQMELCENNFQKVSCIMSLAKIHWEGSQDAEKAILSYEKTLEIIPQNFRAMQKIIDIYTCEKKYDQVIVVCEEYLQKFVEDDEEYKAILSSQAFCYLNHLDAAEKAADIYQRLCEIDPNHTEAHAALADIWATDKKQVENAITEHFYLILQNPFRRDSYNKLFNLYQKENLYDRMYLCCQGALMLGKLLPKEKIFLERITPRVPSGWLDTTTQEKFIPENMRGTLHEVMASVDAYTDKAYPPLWENYPSLEKQESFHENSEMQDCIYRILKFLSIDQVTVYTYDGDGIYLENTNPVSIVIGWKLWQKLTKNAQKFVVTRTLFYAARKQVMAYKLNNEEYVDCVSVLVESFAETGKPISEKREAIIRKLRNSLPRKIKKQLEERMDVLTEVFQADTNAYRLHLEKAANNCALLMSDSLKASIEGYCAVKNIDFANFRDTKYEEMIKALFCFNISEEHSVLRRELGLEIKWLK
>NZ_AP019860.1|WP_151967816.1|2754305_2754998_-|bifunctional-demethylmenaquinone-methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol-methylase-UbiE
MSKKIHDMFAQIAGTYDRTNSVLSLGIHHLWRNRLIKMSETKPGDAILDCATGTGDVAITFYKKNKGQGRIVGTDFCAPMLELAEKKSKSNYPEIEWKIEDAQDLSFPDNTFDIATISFGIRNVDNTEDCLKSMARVVKPGGKVLILEFGQPHWPIKPFFNLYSGYILPFVGGIISGDRKAYKYLNTSSAQFPTGKKFIELMEKTQAFSEVYFKSLTSGVCYIYVGKVAG
>NZ_AP019860.1|WP_151967817.1|2755018_2756602_-|hypothetical-protein
MGTDKNKQKKYVSVRKALRELRVDEGELKKIIEKGAIKAYPDKDNVKFDADEIEKYRTSRIQNNEENPKIADESLYESADVSFDSLFVSQAQGRSAASLTEEIPQEPDILFGPSTPKQNIKDFLNKKKPDPVSPVKAIQSVRSRDKGTTGIVSFSLFIVIIMLISINSFLLLQIGGAPTLPKINESKAINDELVPQISIVGKVVPAQTHVIVAPASGKIKQLVTTKLNKDKVIAVIDNANSLQREQLRMELQQALLTWELQKNKVSGLSAKAQKEIAQISEMYRKKGTVNSSNLSSWKKGVQSFAKSIKPSALDVWLQLQKARQNYELAEKKWLQNAQNNTIKASFAGQLLSSYSKVGNNVQAGDILGEYHSSTHQLQVVMSKSEFRLLEMQNQVTVTLPNDEQQKGKIHSAVAEDHLVKVNISIKMPVNLGMQLKVTFSLKKIPECVLVDRRAVFFQKDIRGESQAMVCKVLRKKGKRYAYPVSVVVGLYDEDYIQILSGVDPGDVIAMATSTPLANFTSGQQLQD
>NZ_AP019860.1|WP_151967818.1|2756744_2758055_-|HEAT-repeat-domain-containing-protein
MSEKLLKNFYKKVLQVLREDNQDKEAAYRLRQLLSSQTPNKDFAKVLAKLGLRDVKLLVDILRKDRSYESPSIDCSQVLSSYMEECLPVFQNYVAHVKNSGNASQNNLETIHNQLEIMQIIHSGVANDDILRIIYGLVKSYQIQPQAFKNVTIAMLNEIGNPVILALVFLLENDEDLPDLFAHLGSIAMPALFIALYYPDAEVRYNAVEVIKKINSSEGLRALAGARNDPCSRVRQKVIEALGDMQDHRSTQILIEALRDEDAGVRLTSVKALGKIRSLKALNALLSMLEDKDWEVRREAVESMALYGEKASGYLAKALENDSLVVKKIASRILSHVGNQEAVPALMKAIYDTDISVRERAVIALGRIQGENSIVTLMFAFEDEAPLVRFAAIQVLIEIGSRSTNHLLNKALKDPEPLIRERANIAIQEILSREEV
>NZ_AP019860.1|WP_173013230.1|2758427_2761487_+|amidohydrolase-family-protein
MFKIRLLCVFIATITLCWSQTEPTQGLRNKTPQIIAITNANVFINPSQKIENATIVIRNGFIESVGQNITIPPEAQIWDVHSSTVYPGFIETFSDYGLPQNSGNNANNSWLPSTNKKGTPAGGRHWNDAVHAEKRAAKAFSANNNKAKELRSQGFTIAQTSSLDGIFRGQSAVVSLGSDPTNNAVLKHNHAQFASFRKGSSKSSYPGSLMGSIALIRQVLMDSSWYQKAYTAYARDTSQKKPELNYSLEALQNVLSGQQSIVFSTSNELSLLRAAKIAQEFGLTFIYKGSGYEYRRLEAIAKLQSILIVPVNFPHVPDITTPERQFDVSLGKLKHWNAAKENPALLERAEIAFAFTTNGLKNSTQFLTNVREAVARGLSTQKALEALTTVPARICGISQIAGTIERGKQANFVISDDDIFAKKSQIYSVWVRGEKFVLKERQKFNFNGKWQVSDNKHTFEIHIENNSKATIHNLEGAHIEDFATNNNQLHFQVVATQGVSRFSGRMWQEKLSGIVLSPQNERSTWQAQRKLNDETKQQKQDEQENTQQQADKMLFEIVYPNKAFGRKTIPQQAYTVFVSNATIWTCAQQGKIEIADMIVREGKIIQIGKDLSPPPEAIVIEGEGIHITPGLIDEHSHIAITRGVNEATQAVTAEVRIGDVVNSDDINIYRQLAGGVTSSQLLHGSANPIGGQAQVIKLRWGNLPEEMKYQDIHKGIKFALGENVKQSNWGDNYTTRYPQTRMGVREIFYDVFQTAREYEKEWQNYRQLSETEKRKVIPPRRDLELEAINDILHKKMFIHCHSYVQSEILSLARLANKFGFSVGTFTHVLEGYKVARELKETGAMASCFSDWWAYKFEVYDAIPYNAAVMHRQGVVVSINSDDAEMARRLNQEAAKAIKYGGLSEEDALKLVTINAAKQLYIDKKVGSLETGKDADFVVWNHHPLSCYSRVLQTWIDGRKYFDVEEDRKMRSEIRRQKAALIQLALNKKAKGEKVEETSAVKKKRHYHCDDIEDAVRGRD

Crispr_ID: NZ_AP019860_13

• CRISPR_ID: NZ_AP019860_13
• CRISPR_location: 2797504-2797586
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_13

Consensus_repeat	Method
ATGTTGGTGCCCTCACCTTCGAATTA	CRISPRCasFinder

spacers of NZ_AP019860_13

>13.1|2797530|31|NZ_AP019860|CRISPRCasFinder
GTGGTTGGTATTTGTTTGGTTTAGCACTTCT

CRISPR arrays and Neighbor proteins around NZ_AP019860_13

CRISPR arrays

The CRISPR arrays of NZ_AP019860_13

>merge|NZ_AP019860|13|2797504-2797586|CRISPRCasFinder
ATGTTGGTGCCCTCACCTTCGAATTAGTGGTTGGTATTTGTTTGGTTTAGCACTTCTATGTTGGTGCCCTCACCTTCGAATTA

>NZ_AP019860|13|10|2797504-2797586|CRISPRCasFinder
ATGTTGGTGCCCTCACCTTCGAATTA	GTGGTTGGTATTTGTTTGGTTTAGCACTTCT
ATGTTGGTGCCCTCACCTTCGAATTA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151967855.1|2804696_2804951_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967851.1|2796376_2797219_-|hypothetical-protein	unknown	unknown	gnl|CDD|371131
NZ_AP019860.1|WP_151967846.1|2791950_2792496_+|hypothetical-protein	unknown	unknown	gnl|CDD|349965
NZ_AP019860.1|WP_151967854.1|2803580_2804687_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967849.1|2794529_2795345_+|hypothetical-protein	unknown	unknown	gnl|CDD|350159
NZ_AP019860.1|WP_151967852.1|2797799_2798771_+|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl|CDD|273938
NZ_AP019860.1|WP_151967848.1|2792940_2794527_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967844.1|2790608_2790905_-|hypothetical-protein	unknown	unknown	gnl|CDD|273996
NZ_AP019860.1|WP_151967858.1|2808266_2809928_-|hypothetical-protein	unknown	unknown	gnl|CDD|275106
NZ_AP019860.1|WP_151967845.1|2791049_2791769_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|226674
NZ_AP019860.1|WP_151967853.1|2799108_2800707_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967847.1|2792488_2792941_+|hypothetical-protein	unknown	unknown	gnl|CDD|349965
NZ_AP019860.1|WP_151967850.1|2795379_2796372_+|DNA-photolyase	unknown	unknown	gnl|CDD|213890
NZ_AP019860.1|WP_151967843.1|2789341_2790262_+|glycosyltransferase	unknown	unknown	gnl|CDD|366154
NZ_AP019860.1|WP_151967860.1|2810867_2812727_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_152021986.1|2801463_2801637_-|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|366316
NZ_AP019860.1|WP_151967842.1|2787249_2789190_+|hypothetical-protein	unknown	unknown	gnl|CDD|273147
NZ_AP019860.1|WP_151967857.1|2806265_2808191_+|hypothetical-protein	unknown	unknown	gnl|CDD|173853
NZ_AP019860.1|WP_151967859.1|2809927_2810866_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_AP019860.1|WP_151967856.1|2804950_2806258_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151967851.1|2796376_2797219_-|hypothetical-protein	gnl|CDD|371131	pfam10552, ORF6C, ORF6C domain. This domain was identified by Iyer and colleagues.	0.000137494
NZ_AP019860.1|WP_151967846.1|2791950_2792496_+|hypothetical-protein	gnl|CDD|349965	cd18092, SpoU-like_TrmH, SAM-dependent tRNA methylase related to TrmH. TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	3.68797e-18
NZ_AP019860.1|WP_151967849.1|2794529_2795345_+|hypothetical-protein	gnl|CDD|350159	cd09008, MTAN, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	7.37596e-10
NZ_AP019860.1|WP_151967852.1|2797799_2798771_+|trypsin-like-peptidase-domain-containing-protein	gnl|CDD|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.432e-29
NZ_AP019860.1|WP_151967844.1|2790608_2790905_-|hypothetical-protein	gnl|CDD|273996	TIGR02147, Fsuc_second, TIGR02147 family protein. This family consists of the 40 members of a paralogous protein family in the rumen anaerobe Fibrobacter succinogenes S85 and a smaller number in Bdellovibrio bacteriovorus HD100. Member proteins are about 270 residues long and appear to lack signal sequences and transmembrane helices. The only perfectly conserved residue is a glycine in an otherwise poorly conserved region, suggesting members are not enzymes. The family is not characterized. [Hypothetical proteins, Conserved].	1.37109e-05
NZ_AP019860.1|WP_151967858.1|2808266_2809928_-|hypothetical-protein	gnl|CDD|275106	TIGR04286, hypothetical_protein_HMPREF9455_00034, MSEP-CTERM protein. Members of this protein family average over 900 residues in length and appear to have multiple membrane-spanning helices in the N-terminal half. The extreme C-terminal region consists of a motif with consensus sequence MSEP, then a transmembrane alpha helix, then a short region with several basic residues. This region, hereby dubbed MSEP-CTERM, resembles other putative sorting signals associated with the archaeosortase/exosortase protein family (see TIGR04178). Genes for all members of this family are found next to a gene for exosortase K.	1.35711e-06
NZ_AP019860.1|WP_151967845.1|2791049_2791769_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	4.77269e-98
NZ_AP019860.1|WP_151967847.1|2792488_2792941_+|hypothetical-protein	gnl|CDD|349965	cd18092, SpoU-like_TrmH, SAM-dependent tRNA methylase related to TrmH. TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.	1.77298e-34
NZ_AP019860.1|WP_151967850.1|2795379_2796372_+|DNA-photolyase	gnl|CDD|213890	TIGR04070, photo_TT_lyase, spore photoproduct lyase. DNA damage to bacterial spores from ultraviolet light accumulates in the form of 5-thyminyl-5,6-dihydrothymine, spore photoproduct. The damage is repaired by spore photoproduct lyase, a member of the radical SAM family of enzymes. The score of this model is set to restrict itself to spore-forming members of the Firmicutes, but additional homologs scoring below the trusted cutoff tend to occur in radioresistant organisms (e.g. Kineococcus radiotolerans) and may be functionally equivalent. A related family in the Mycobacterium lineage is described by family TIGR03886, and may or may not be equivalent in function. [DNA metabolism, DNA replication, recombination, and repair, Cellular processes, Sporulation and germination].	4.91853e-13
NZ_AP019860.1|WP_151967843.1|2789341_2790262_+|glycosyltransferase	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.89986e-23
NZ_AP019860.1|WP_152021986.1|2801463_2801637_-|pentapeptide-repeat-containing-protein	gnl|CDD|366316	pfam00805, Pentapeptide, Pentapeptide repeats (8 copies). These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.	0.000948691
NZ_AP019860.1|WP_151967842.1|2787249_2789190_+|hypothetical-protein	gnl|CDD|273147	TIGR00574, DNA_ligase, DNA ligase I, ATP-dependent (dnl1). All proteins in this family with known functions are ATP-dependent DNA ligases. Functions include DNA repair, DNA replication, and DNA recombination (or any process requiring ligation of two single-stranded DNA sections). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair].	5.40152e-43
NZ_AP019860.1|WP_151967857.1|2806265_2808191_+|hypothetical-protein	gnl|CDD|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	8.09295e-16
NZ_AP019860.1|WP_151967859.1|2809927_2810866_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.60254e-91

Protein sequences

>NZ_AP019860.1|WP_151967851.1|2796376_2797219_-|hypothetical-protein
MNEYLLLESETFRKKLCTDQNTCVLNEVGKLESFTENGWTTTEYIAKFYDVAVPTVKSVVLRNKNEVIMDGYKIIQKKDLRAPKFRKMFGTDIEKKIKPLHSKTRSIALFSRRAVLRIGMLLRDSEVAKKVRSYLLNSENRTLNNEQQHRRLLGQMAHQLTQQASQLAKNAEQLICQANLVTAAVNEIERTKEMVKRIDERVELQEQRLQALENSLRPNNKQQKISEEQVLLLKIELKKKKKHAVSVWSKFNKHFGLKSYANLPASSFDVALKWMKNYKG
>NZ_AP019860.1|WP_151967850.1|2795379_2796372_+|DNA-photolyase
MIDTIYIEEEIKEHARTQEICQRFPKARIVFCERYGEVFNRKVQNFRLQKQKPALILAKKFQHFVLEAPEGYGIGAKKNFYFSHMMNCIYDCRYCFLQGMYRSAHYLLFINFEDFAASIEQIRKEHPTQQVHFFSGYDCDSLALDQVTKFSEYFVPLFPRSQNAWLELRTKSVNVKPLLAMRDHNCIAAFSFTPQVISEKIEDKVPSVSARLSAIEKLQQCGWNIGLRFDPLIYHREYRENYQKLFAQIFAKIDLDCLHSVSLGQFRLPKTMFNNIHKLYPDEKLFAGPLVEKSGMVSYEGELGEEMFDFCTTELLKYIDKNVFFPCVYE
>NZ_AP019860.1|WP_151967849.1|2794529_2795345_+|hypothetical-protein
MQILFVVALQSEATTLIKFYKLKLYSETPFKIYRNEDTWLIVSGIGRINCAAATAYLQCTAQNEQYQLWINVGIAGHKDLELGQAIVAHKIVDANTQKKWYPPILVNLPVQTATVITVDVPETNYPTASAYEMEASSFYEIATKFATSEFVHCFKVISDNEEQHIQNITRQKVQQLIEQNMPHIDNICSQLQQVAKSLPPKIPQEWQDILQQWKFTAAGQKRLRNLLQKWQTLNPENKLLNDEMREQCSHMKQVLQFIEKKVQCASREMSL
>NZ_AP019860.1|WP_151967848.1|2792940_2794527_+|hypothetical-protein
MAKKPKRKRNLNRIVQEICAILIGIGIGLYGYESKAALVPMKWQLERKVAKDIHRQQQTQQVSGGSVFDAFSQIPAVNNFWKKTGADRYLSNIQKYNTVMQKWGLRGDLQQKMDSLMKNGVETVPRRWTTPENKPFFILGILLVCVALLTKIAIYSGMLNLNRLGQKRGKKKKKRANINAIANEISTFGLSAIGGLYLMPALENFMRNENASFPYPWVIAGIFIALVLLKVALNSSLIDFNAWRRGGKMVSNQRFQKFSKTYNWNTFAHQVTTAILGIFLGFYAYESNLALLPMKWQMDRQVGQEVAGNTTTTPQKKEPGFFDNVWKTVRKVAPIVRDTDFWKKSGAERYAQYAQKYDSALERSGVKGYLKTKVKRLASGGVDYVPDRWTQKGNLPFLLAALIITVLSFLIKWCLYLHIIDFNDWIKRRKLVRKNKKKPPVNWNAIVQETASIILGVMLGIYTEPFLDYLAGEPNVTYPYPSAGPIIVIVCVAIKVALHTKMINFNKKRVAKKAPVVKKAPVKRKRRR
>NZ_AP019860.1|WP_151967847.1|2792488_2792941_+|hypothetical-protein
MADHITQVFIDNAWDPRNHKAILNLCLGFGVDKIYLYHSYNYYERETYEKMDDIEVEDVTDLALFHQQKSEDGFQFIAADFDENAQKICDFTFPEKSMVVFGAEKLGISPEVKELCDHIIYIPMVGLVQSFNISVSVGIFCYEIFKQRNK
>NZ_AP019860.1|WP_151967846.1|2791950_2792496_+|hypothetical-protein
MNPRRQQLVEAYYKNKITDIEILVDNFANPHDIAAITRSADGLGIKKIYLYYTYAPYPCMVSQGKKSSASANKWILYERVEDLQQFFSQKKDWNFLGLVQQKTSQFICDYEFTEKTILVVPSPEQGLSSELACDHFISPPFLHDASYSTSTAVAMSLYEIFTQHGKHLQPLSSLVPRGKRG
>NZ_AP019860.1|WP_151967845.1|2791049_2791769_+|SDR-family-NAD(P)-dependent-oxidoreductase
MEKLVVITGASSGIGAATAKLFSEKGHPLLLLARRIEKLRELDLPDTICSQVDVTDRKALQEAIDKAEEKYGTTDCLVNNAGVMLLGLANSQDPKEWQKMFDVNVHGVLNGIHCVLQKMINCNSGTVINISSIAGRKTFPNHAAYCGTKFAVHAMTENIREEVAEHNVRVITIAPGAVETELLGHTTSTEIKDGYEDWKKSMGGAIQSSDIANAIYYAYSQPQNVCIREIVLAATKQQP
>NZ_AP019860.1|WP_151967844.1|2790608_2790905_-|hypothetical-protein
MGQKIPFYVEYLCNELQDRVARNPQYSLRAFAKFLDIDASFLSKVMSRKKVLSLKKVDEIVEKLRLTEEERKKFILSIANEQKCASLTKVDNDLTSCD
>NZ_AP019860.1|WP_151967843.1|2789341_2790262_+|glycosyltransferase
MKRISICVPTYNRKKLLKKALDSCLAQTHLPHEIIIGDDSTNLETKLMVKNLQQEVPNINIRYFKHSSNLGQHKNAMFLIQKVEGEYLLILHDDDELEKEALADYLRCFSKCDDIVAVYGKQYFIDEQNLPHGNSEDLNKLFFREKKYEGLQADSLKMAILQQFNGSFMVRTDIVTQINYNDLGAIGQDAIDFFFGLEMAKYGKFYFLNKYTAKYRVGNVSVSNNKKNNAGYNAFKYVFENFRGKQPEIEMWLTRKSNVAVMQAINLKDKKNAFKWYFSKYHKSKIFTPGGIKRLILLCTPNLKRN
>NZ_AP019860.1|WP_151967842.1|2787249_2789190_+|hypothetical-protein
MKPEEITIIDDKFIREYSLKRGLVESYIEVQKGLGRKKKNKNYAAELLGLPVSLTFALENVVRLQKDQSLDSISFFSLLYGLYLPLCGMNEQKTLQTFGIYWKSRVGNHQGLISEFLHKDLGLSLEEKINFLMGDPFSGKAARMGQDTLINILASIRLVSHQFLRAHLTKIADFGLLFTEEVSKIKSDPPVTAKEVIVILRNLPRQKTNRKKQILRDLFERCGRLERYFLARLILRRLYFGYEYRSSLIHTELAKKYNISEEIIGNSIALSDIFNVCEILENKGAKGLEKLVLKPLNPVSPALAGTVEVTKNSKFPMWVECKYDGIRLMLHKDTSINSRVKYAAFTRRKNDWINLVPELENSAKWLQAYSYILDGELHGTYVDLEKGGLRPANVYDVYRQLQGNYSLPIKLQYVVFDILYLNGKDLTKEPWYKRRQLLEKLIMPSSGYQVNVPIIVAEGWEAKNYSEFKKWFKNFENRGYEGAMAKIIKDSYALGKRNNSWLKKKPAIYLDLAVTGALWSTTDRGPKIFSTFLLSCRHKNGYEQVARTEGLAYQQNHEILQRITYDGLLTGENVEIRTSTATRYGFKLIPSIVVTIRIDGVVRDNEGVYSLRDPKIVCVRPRGDMIAEDVNTRDDIAQLYVKTRLK
>NZ_AP019860.1|WP_151967852.1|2797799_2798771_+|trypsin-like-peptidase-domain-containing-protein
MKKIICCFVIALNVLIAQRSYLNELYQKIRPSIVAVDVDVPEEIRKEGILKRGIYYGTGFVIGKNLVLTTRKVMQDKLSARCICYDNRIIKAQVVAYDEHSPLTLLKINYPQLPALELSEEYAVGDLVVSVGNTYGSIAKVSEFSVSYGMVSGIYDFERWGIVLRDIMETDCAINPGIYGGPIINMHGKIVATCFSGYAQDRHKGLGIPSPTINNFLQRYYANKIALPDEFFFLQTFPVYLGVELALENRRPKIVAIEPESPAEEGLLVGDKILQINDFEITSIEKFRKIIQTYFPGQKVSLTIRRKKMIIVVPVALTARFMR
>NZ_AP019860.1|WP_151967853.1|2799108_2800707_+|hypothetical-protein
MLDLLYIGSIEYWFEHYKWGMLFAAFFVFIVYLNKIHSKNINKAENKNTGHLNVKPKSIGEALLLHQQQTMSEIHQKNQDLNLKRNDKVRKFRFSTQQLHRLKEKPSREEETVVDDREIEISFRLLTDFDVMLPKIKGTYDDFLESIEKFCGIFAETKQISLENIQNLLHQKKYRDIIVLIQECIEKHEQPLVLKKSKFFKWLQYGGFLEIAEEDGSSFVIDYHNIQLCEEINQLIQELLVKNYCRAHGCQFDSVDELIEEVALEKLQEIKFVTTYSGIGSDISELLVEDFMRMLNSKKKSSSIKYRSLRVIFGNDNQDFYKVGELVWAAISDIQRLHQNLLEKIAMSTAEIQQLIVSKNTALADSSFTAPRPTYTDQQVEEEKILRSTVLMIVDFLNWYPQDESAISEADHELINYFDKLLYSRKSRFAIVCDKNKNGAAKTFAKHLKVVSKQLEYTDKIVKKITLEKLVGMDIKIAVPRQCEDYFPVKGSIINVFNEETDFGNIIKFEVAEKNQLTSSIIFTGKNVDFIY
>NZ_AP019860.1|WP_152021986.1|2801463_2801637_-|pentapeptide-repeat-containing-protein
MRTAFRRATFRRATFRRAAFRRATFRRAAFRRANFRRASLLRRFFQWTRRFFEGFVC
>NZ_AP019860.1|WP_151967854.1|2803580_2804687_+|hypothetical-protein
MSLKTKYISLFFVFATMVYADTKIELKFSTDKGLIHSANALYENSWEIQKKNKTLTTQAAAKYIKFYNVSIVKRGGATLEIFTLPSTANSLSWKIPNTTKNEILIVTVTAVPKRKAFPRIRGKTHFYVVPNPPSLKLPKDFSQSLVVLMDWNGKRGFCKKLAPLKALEYAQATCKYIRQNYNGDDYGQYLEVITKVETASVAYTTIYCETKRARVNIDGHNIGFFENWDAKRRMYSLRFLLPVRAQKTYKISVAKGEYTYTGSFIHAKSSELVVNLSKKVSVVISCKQPFKIKTPRIRTELGNKHQIYVHQEKVTSISLQFSNVTLRIDFIAKDNNRWLIEKNQQYFSLNIDGKSYPFINNKVSLLDF
>NZ_AP019860.1|WP_151967855.1|2804696_2804951_+|hypothetical-protein
MRLAIIATTILLLSGCVSSPLQETVEIQQNTIDDLSSRLEKLEGKLDIQQQKIDGLEKELSTMKSGLRKVTPGYLEGTIQEGNF
>NZ_AP019860.1|WP_151967856.1|2804950_2806258_+|hypothetical-protein
MWKIVLVCAVVFCACNNKTQITPNDTDDNFLLKARESYSKKQFTQSASLFVKAQKVKQQSEISEAQLGEILCLVAVDGAFQEKIDAWDVGRLYYWKGYSLDPFAEIPASYQQKFRDVGNHKLFHVLDLLLETGHDKSIQSFLQVYSQSNLQTFIVAKAWYALENNSYDEAKRLFSLVNDDKQHRLIRQSGTLLTKVLLKKQVTSSDLKDIIKNKYFFIANKKIELEVNEQSVVGNMLFHFGVMAKHSIPIWEQGKTFIAQNANDMSQEAHDDYLQLFSLATAWKLFTKGDLTSAKQNFQKIVANKKKLSRYCEAHLGLAVILWMEEEDYEEVHSHFTWLNKYSYWLGGKSISLFIEKRRPQKAWQKVLQKNSEHKVYLVLLDTLCRLGEGRSAYALLGTLMSDFEDADLISLYEKEDKNIPKDVYAENKIWEKID
>NZ_AP019860.1|WP_151967857.1|2806265_2808191_+|hypothetical-protein
MNKLQYICATFLFFSLCFAQEEIVYAEMEFPLSFVEQIRQYTFNPLARFQTQVEGRIIELTTDPLVDIYQVTSGQQAYRPCLASFRTVKLREQTVLSFNLQNANFNDGQPLGFEDVLFSLEYKKLNPDSWKVNNNLVITKQGSNSFNAFYGNSANTAPLPGEFYFPIVDKRSYIKNEEPSKARVSKRKQQHIGYGRYHVDQIQENRFIKMRRTKDHPYYKNLQYPPNHRPIEYIKMFSFPNARITRNEQFINGNVHLITETLQTDVSYINNTLGKKNVKTLRYSDDSFSGFVLNCEHPYLVPSAVRRALNYMVRKRLMLKKALSGEGEIIAAPLPRRNFFYNTTVRPYKDDSTIALNLLKLYRYWGLDVYEGDKRVVVYSGSGERVKEFQTGDIIQEVERVSITNIAELLQELEKRKEEEIVRVKVINGNRVFVRRIQNKLGVDVGIWKSVNITSSGLLGFPKLSLIANNPQGKNQLVKQICGALKEDLAKFGMEITIDYLVPDSYYPRLQKGDFDIAFRTVKLTGTPNLTRLFQHKKGQKKIKNVNYGRYHNATINKIASSTRDVTNVKILQQAWRKAFSILHHDPPYICLWSRNHIIMHDPKLKVLSPGPEYKVPHGYTQINGLINIFNEVHLWAVSDR
>NZ_AP019860.1|WP_151967858.1|2808266_2809928_-|hypothetical-protein
MEFFDRYINPIHLLGLRSYLRTKRFLYTFNISVLLMVSAMLLGFFFMSIERMPTAQIGKNLFMIFSIMQYVIIGLVFPAFSCTAIISEKEGKTYDLLVTANLSSGDIVWGKFLSAYTHSAMFLISSLPIVMMAFLFGGITPALIMITYAILFAYAALIVMLCLSISSVYKTITRAIIASYIVVIIINSFISPMLFFLLYDYLHDSELARFFIAIGGYGSLNVFLTVYIVPVFVFLSLIFAPYLVAKNSLRTYANNRSTSLKVYFTCVGSGILAIFLTYYINSIYMFIGIQQLDYEMIMMVGGFCLAIAGIFGLIGSLGFAGENPVPERFVMKRLSEHLKAGRIRRVFASKFFLGLLGPGSYRGARFVTLMCFGWTAIYLLATWLLIEKFGVNNTVFWRNYEASGYMEYPIISAFVVVSFVYFFSMLASFLSFRIRQIGFRRAVLFCMLLFLTILLPLYSLFSMEVYGGFHASILNFQYLSPSMCFFWSFIPISQFGGSKFSCLIDGVPIHYIGIGVYFSLGFLLDLLNYRRSRKMWNELEKEEKEILESMDKK
>NZ_AP019860.1|WP_151967859.1|2809927_2810866_-|ATP-binding-cassette-domain-containing-protein
MILLKDLTKIFGSFLAVDHLSFEVPAGEIFGFIGPNGAGKTTTIKMLATLLQPDSGVARIDGHCVYTDPEKVRQVMGYMPDYFGTYDNVTIHEFLDFFARAYRIPAKTRQSTIDGCMELTDLKKLQTKLVSSLSKGMKQRLCLAKTLLHNPKVLILDEPAAGLDPRARIEFRSLLKELRNMKKTVFISSHILTELSDIVDSVAIVEKGRLVVSGDLQTISRLSSTQNHIDLRIRIHDKEQIESALGIVQQTENVVNARVENDSILMEYNEEIDKMYLVLKQLVNADIPVTEVTSSQSNLEDIFMRVTQGEVS
>NZ_AP019860.1|WP_151967860.1|2810867_2812727_-|hypothetical-protein
MRRPLLLLFLLCCCYGQTVLYDTLVKTKSKLKIEKLRAIGNFSSHAMEYMTVSGVFVTDASWKKKKISLRVHSTDYGQEWTISQDMELLPSSKRSFRLYGHTKRRVDEIKFSVFFDGKEVIRASFSPSQRYDTFRILYVSPKNYLDGSLLQPRIQDDLKGYRNGVEMEKIQPHDLPTHWLEYRNVDALIINSDRPFLDIKSMSDPRATALFDWLKMGGHVIVSCGSHLFLSKNTFMQNLFSVAEISTESRSSEELQKFSFGKSQYAFKHPKQSAVVDDLLWTLDYGYGKITYIGGDVKNYAQANKERGFWLNCFSPRQNAQNSTVFFKDDEGDYINRADFTKERAPILTLIITLMLIYVLVIGPFNFSFLRKRNRTIYLIFTIPAIAILFSFVVLFYGFFSKGVSNIGKKISFYYSLEDNRCYAKEYLSVSSGAKSLYDIAGSEGATVTKLFDRRDEHIQYRQDNGIFIKDYPINLWETRFFRVDSVFDHNSLTVERRKNRLSVQNNLQVKIKKAYYVEGTTRYVYTLSAEENSSFTFQAKPDYSLKRYGDSQIFWEKQGVPSHFAKVISSEIQRYISYTKRDFIMTFIDKDFTPTQTSPRVNFNENLQILITPLTREN

Crispr_ID: NZ_AP019860_14

• CRISPR_ID: NZ_AP019860_14
• CRISPR_location: 3017971-3018067
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_14

Consensus_repeat	Method
ATTGGTGCCCTCACCATCGAATT	CRISPRCasFinder

spacers of NZ_AP019860_14

>14.1|3017994|51|NZ_AP019860|CRISPRCasFinder
AGCAGTTACAGCTGTGCTGTAAGCAACATAACAAAAGAAATTTGTTTCCGG

CRISPR arrays and Neighbor proteins around NZ_AP019860_14

CRISPR arrays

The CRISPR arrays of NZ_AP019860_14

>merge|NZ_AP019860|14|3017971-3018067|CRISPRCasFinder
ATTGGTGCCCTCACCATCGAATTAGCAGTTACAGCTGTGCTGTAAGCAACATAACAAAAGAAATTTGTTTCCGGATTGGTGCCCTCACCATCGAATT

>NZ_AP019860|14|11|3017971-3018067|CRISPRCasFinder
ATTGGTGCCCTCACCATCGAATT	AGCAGTTACAGCTGTGCTGTAAGCAACATAACAAAAGAAATTTGTTTCCGG
ATTGGTGCCCTCACCATCGAATT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151968001.1|3026802_3027090_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013242.1|3011001_3011952_+|hypothetical-protein	unknown	unknown	gnl|CDD|276965
NZ_AP019860.1|WP_173013243.1|3029641_3031030_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl|CDD|225174
NZ_AP019860.1|WP_151967987.1|3009032_3009872_-|EamA-family-transporter	unknown	unknown	gnl|CDD|274527
NZ_AP019860.1|WP_151967995.1|3018878_3022013_-|isoleucine--tRNA-ligase	unknown	unknown	gnl|CDD|235681
NZ_AP019860.1|WP_151967993.1|3017311_3017956_+|hypothetical-protein	unknown	unknown	gnl|CDD|215002
NZ_AP019860.1|WP_152021991.1|3012713_3013109_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967998.1|3023176_3024427_-|tyrosine--tRNA-ligase	unknown	unknown	gnl|CDD|235645
NZ_AP019860.1|WP_151968000.1|3025853_3026792_-|aldo/keto-reductase	unknown	unknown	gnl|CDD|381369
NZ_AP019860.1|WP_151967994.1|3018367_3018817_-|MAPEG-family-protein	unknown	unknown	gnl|CDD|376462
NZ_AP019860.1|WP_151967988.1|3009980_3010856_+|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293786
NZ_AP019860.1|WP_151968002.1|3027384_3029562_+|hypothetical-protein	unknown	unknown	gnl|CDD|368014
NZ_AP019860.1|WP_151967996.1|3022014_3022407_-|HIT-domain-containing-protein	unknown	unknown	gnl|CDD|223611
NZ_AP019860.1|WP_151967999.1|3024497_3025817_-|6-phosphofructokinase	unknown	unknown	gnl|CDD|223283
NZ_AP019860.1|WP_151967992.1|3015874_3017275_+|RRXRR-domain-containing-protein	unknown	unknown	gnl|CDD|379519
NZ_AP019860.1|WP_151967997.1|3022390_3023113_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151967990.1|3011968_3012496_+|flavodoxin-domain-containing-protein	unknown	unknown	gnl|CDD|236439
NZ_AP019860.1|WP_151967991.1|3013113_3015615_+|DUF4132-domain-containing-protein	unknown	unknown	gnl|CDD|379270
NZ_AP019860.1|WP_151967985.1|3003442_3007561_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151967986.1|3007671_3009015_+|SBBP-repeat-containing-protein	unknown	unknown	gnl|CDD|271320

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_173013242.1|3011001_3011952_+|hypothetical-protein	gnl|CDD|276965	sd00038, Kelch, Kelch repeat. Kelch repeats are 44 to 56 amino acids in length and form a four-stranded beta-sheet corresponding to a single blade of five to seven bladed beta propellers. The Kelch superfamily is a large evolutionary conserved protein family whose members are present throughout the cell and extracellularly, and have diverse activities. Kelch repeats are often in combination with other domains, like BTB and BACK or F-box domains.	9.27729e-34
NZ_AP019860.1|WP_173013243.1|3029641_3031030_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl|CDD|225174	COG2265, TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis].	1.99388e-112
NZ_AP019860.1|WP_151967987.1|3009032_3009872_-|EamA-family-transporter	gnl|CDD|274527	TIGR03340, phn_DUF6, phosphonate utilization associated putative membrane protein. This family of hydrophobic proteins has some homology to families of integral membrane proteins such as (pfam00892) and may be a permease. It occurs in the vicinity of various types of operons for the catabolism of phosphonates in Vibrio, Pseudomonas, Polaromonas and Thiomicrospira.	1.59632e-30
NZ_AP019860.1|WP_151967993.1|3017311_3017956_+|hypothetical-protein	gnl|CDD|215002	smart01059, CAT, Chloramphenicol acetyltransferase. Chloramphenicol acetyltransferase (CAT).catalyzes the acetyl-CoA dependent acetylation of chloramphenicol (Cm), an antibiotic which inhibits prokaryotic peptidyltransferase activity. Acetylation of Cm by CAT inactivates the antibiotic. A histidine residue, located in the C-terminal section of the enzyme, plays a central role in its catalytic mechanism. There is a second family of CAT. evolutionary unrelated to the main family described above. These CAT belong to the bacterial hexapeptide-repeat containing-transferases family (see ). The crystal structure of the type III enzyme from Escherichia coli with chloramphenicol bound has been determined. CAT is a trimer of identical subunits (monomer Mr 25,000) and the trimeric structure is stabilised by a number of hydrogen bonds, some of which result in the extension of a beta-sheet across the subunit interface. Chloramphenicol binds in a deep pocket located at the boundary between adjacent subunits of the trimer, such that the majority of residues forming the binding pocket belong to one subunit while the catalytically essential histidine belongs to the adjacent subunit. His195 is appropriately positioned to act as a general base catalyst in the reaction, and the required tautomeric stabilisation is provided by an unusual interaction with a main-chain carbonyl oxygen.	4.91084e-72
NZ_AP019860.1|WP_151967995.1|3018878_3022013_-|isoleucine--tRNA-ligase	gnl|CDD|235681	PRK06039, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
NZ_AP019860.1|WP_151967998.1|3023176_3024427_-|tyrosine--tRNA-ligase	gnl|CDD|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
NZ_AP019860.1|WP_151967994.1|3018367_3018817_-|MAPEG-family-protein	gnl|CDD|376462	pfam01124, MAPEG, MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.	5.1905e-12
NZ_AP019860.1|WP_151967988.1|3009980_3010856_+|ankyrin-repeat-domain-containing-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.95536e-29
NZ_AP019860.1|WP_151968002.1|3027384_3029562_+|hypothetical-protein	gnl|CDD|368014	pfam04592, SelP_N, Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated. SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region. Zebrafish selenoprotein Pb lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins. It is speculated that the N terminal region may adopt a thioredoxin fold and catalyze redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding. Binding to heparan proteoglycans could account for the membrane binding properties of SelP. The function of the bacterial members of this family is uncharacterized.	2.61164e-06
NZ_AP019860.1|WP_151967996.1|3022014_3022407_-|HIT-domain-containing-protein	gnl|CDD|223611	COG0537, Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only].	3.99759e-36
NZ_AP019860.1|WP_151968000.1|3025853_3026792_-|aldo/keto-reductase	gnl|CDD|381369	cd19143, AKR_AKR6C1_2, AKR6C family of aldo-keto reductase (AKR). Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.	0
NZ_AP019860.1|WP_151967992.1|3015874_3017275_+|RRXRR-domain-containing-protein	gnl|CDD|379519	pfam14239, RRXRR, RRXRR protein. This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with pfam01844.	3.64141e-85
NZ_AP019860.1|WP_151967999.1|3024497_3025817_-|6-phosphofructokinase	gnl|CDD|223283	COG0205, PfkA, 6-phosphofructokinase [Carbohydrate transport and metabolism].	6.79614e-82
NZ_AP019860.1|WP_151967990.1|3011968_3012496_+|flavodoxin-domain-containing-protein	gnl|CDD|236439	PRK09267, PRK09267, flavodoxin FldA; Validated.	1.76401e-43
NZ_AP019860.1|WP_151967991.1|3013113_3015615_+|DUF4132-domain-containing-protein	gnl|CDD|379270	pfam13569, DUF4132, Domain of unknown function (DUF4132). This domain might be involved in the biosynthesis of the molybdopterin cofactor in E.coli.	3.25208e-48
NZ_AP019860.1|WP_151967985.1|3003442_3007561_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.85807e-79
NZ_AP019860.1|WP_151967986.1|3007671_3009015_+|SBBP-repeat-containing-protein	gnl|CDD|271320	cd05819, NHL, NHL repeat unit of beta-propeller proteins. The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.	3.4617e-12

Protein sequences

>NZ_AP019860.1|WP_151967993.1|3017311_3017956_+|hypothetical-protein
MPAQQYLDIDNWSRREQYYFFKAYENPFFNICTMLNIKNLLTYCKDNSIPLSHAYFYLSQKAVNEVSEMRYRIHNDKVVIHDHIDAGWVMMKEDGSIRFCYLHYTTEFDNFRAQIEEITRNIEDLPFDSNEQRDDLVYYSVLPWIHFTGLSHAHRMPRNDSVPRIVFGKYKQQEDEVNMPVAVEVHHALMDGFHVAQYLEKLQRFFDGCGDFLV
>NZ_AP019860.1|WP_151967992.1|3015874_3017275_+|RRXRR-domain-containing-protein
MQRRVFVLSKNRKPLMPCSPARARQLLKERKASVYRQEPFTIILQKRTQGDLQKVQLKFDPGSKITGMALVVFFQKGTIVTWAAELEHRGEKIVDLLSKRRAIRRSRRNRKTRYRPPRFSNRTRKKEWIAPSLKSKVDNIFNWTKKLLTYTPIDNLCVETNRFDTQKLQNPEISGVEYQQGTLFGYEIREYLLYKWNHQCVYCDAENVALEIDHIHPRSKGGSNRVSNLTISCRKCNENKGNGDIHNFLSKDNKRLQKIVSYSKKTLRDAASINTTRYVIGNQLKKLGIDVEFASGGKTKANRRHNGFNKQHWIDAACAGESGENVTISQDLIPLGIQSQGRGSRQMCRMDQFGFPRTTAKSQKRVKDFQTGDIVKAIVTKGKKKGVYVGRVAVRSNGYFNIKTNNSTVQGISYRYCQLIQQVDGYFYFQKGDARLKKASCSCFAHSRQSGDSSPTYRSRGILAIN
>NZ_AP019860.1|WP_151967991.1|3013113_3015615_+|DUF4132-domain-containing-protein
MAQQKIGPDRFDYTNSPFALGHQFLDAFIESGLNGPGFDKKDIMQQEKPTQIIILHAALERITWAHIPKKNHFLITLVKIKHEQDYNDRIGCVLDIVYPEIETLVQEIMSLTQPYTPEDVEDILIAAVNIAQLNLKHPHHAVTPGLIPGILKHLKKKRNQNCIPMAKPLLQQLKEPYAASFLYGGEKSLKALDNFLEDSESQDPKIKSLPKGGEHWAELLISQIDKLPKIWYKLLQHAPVANRNSPSTSWLKKAQKLIKDVDDKQFCKYVGNWLSELKRETKRLQDKNAHILKGFVWYCSLVSKPPLQAIGDAVEGGLKKTPQGLVCSKIAAACFYTLEQIGTMEALMQLIRLKMRIKSPWGLEQIQLVIDKLKDRHQMTEEQIQEIAVPQLSKLEYEIAGCRAQIVITGTQTSVQWFNTSGKTQKSVPVQVKKQHPQQLKDIKKVAKDTQTMLVAQKARLERLFLADISWSYSLWQERYLNQSLLSVLTKKLIWLFKKDKRHSCGIYHDGKIIDVNGKQIKWLDKETTVQLWHPIGFSSNEVLKWREFLEHKEIVQPFKQAHREVYIITDAEFTTDTYSNRFAAHIIKQHLLTTLCQQRNWQYDVLGSWDSGDAGVARLKLEKWNLTAEFMIHYSGDDSTSPAGVINYVSTDRVHFVGAEDYVRLCDVPAFIFSEVMRDIDLFVSISSIGNDPQWQDGDHYEYWESYSFGDLSESAAMRKDTLERLIPKLKIADVCSIEGKYLYVKGKIRHYKIHLGSGNILMAPNDQYLCIVQDVIKQRKQGNVFLPFAGDNRLALILSKAFMLAADDKIKDKTILAQIEVNYPHLVPNGT
>NZ_AP019860.1|WP_152021991.1|3012713_3013109_+|hypothetical-protein
MVQQVSIHDEYANGDRFHTLTIDMLTTHITLRELIRRRVYQEVKDYNNSTPGYFQGLVQPKEAEKVLNGYKLREKRKIDWEQQYKLAIDAFTQNGYFVLVDHQQIEDLDTQIELRVDTEVCFIKLVPLVGG
>NZ_AP019860.1|WP_151967990.1|3011968_3012496_+|flavodoxin-domain-containing-protein
MDKFIGIFYATGAGNTKTVAEEIQKELGEDRTDIFDIFHIKKKDYSIFDEYDFLIFGSPTYTGGTMHFRWKSVFPFLKKLDFSERYVALFTLGDRKNYPKKFALALNQMHNELKNCYDIAFLGECTPEDYHYTKSAFLGQKKIHGLAIDQHNEKNLTPQRIQTWVNHLREYIDDW
>NZ_AP019860.1|WP_173013242.1|3011001_3011952_+|hypothetical-protein
MKKILCILAMITALCANDQMYNFPDMPEKLTSLGGVIVDNTIYLYGGHAGKPHSYSKEEQSNRLWKLELKKDAGWEKISEGATRMQGLAMVAHGKSLYRIGGFSAKNSTGEKHDLWSTKEFFCYTDKWQQLPDLPERRSSHGAAIADGKIYIAGGWSMESKKKTWHKTVYVYDTNSDGAKWEKLADTPFTRRALAVIAFQDKVYVIGGMQEVGGPTTKVGVYDIKTNTWADGPQLQGSKMTGFGCSAAVLNGELYVSTVTGSLQKLDTKDNKWVVVSEIGPRFFHQMLPIKDGFVMVGGGSMMGKTAKLDVVKVTK
>NZ_AP019860.1|WP_151967988.1|3009980_3010856_+|ankyrin-repeat-domain-containing-protein
MKIYALIFFMLISGCTSTLNNDLPQRKTAKIVDSENPEVDGILLIDAAKQGDAETVYEFILQGADLDMQDDQGYTPLIVASREGHLQVVESILSAGADVHLRSKAGETAITVAAQGGYRDIISALIEAKCDINTQDANGETALSFAIWNGHSNVAQLLIAKGANVNTAKQNGRTPLMFASLLGDHEMVEKLLSQGAQVNTKDKFGETALIFAVSEKHEKTVALLIKSKANVDAQNDKGVTPLMIAAEQQQLQIIKRLLAVGAKKNIKDRAGKTALDYAKAQKNKAIIAAFK
>NZ_AP019860.1|WP_151967987.1|3009032_3009872_-|EamA-family-transporter
MHSDIYLLVFLSAFMHALWNLAARKVKGDMGVLWLSVLLATLVSTPVYFLIPFDFSLYLSALPYIIATGVIHAFYFIFLSKAYEEGHISFVYPIARGTGVAGTAILAFVLLNEQISLYGGIAIAAILCGTITMALGNFTSDKKSALLAFSVGVSIALYSIVDKLGVQKIHPAIYIAQMFLFSILLAAPYVMLKHKNKCLNALRKHKKYIAIVGCGSISTYALILFAFRLGHVSYIVALRECSVVLGAIFGILFFKEHCNAKKVMAITMIVCGVILLKMG
>NZ_AP019860.1|WP_151967986.1|3007671_3009015_+|SBBP-repeat-containing-protein
MNKIYLLLFIFFLPLLSAQNQIKIDWNTFSGSRYEDYGRSVAIDHKGNIYITGKSLDTWGKPLKSHTGKSDIFIAKYSPAGILMWNTFIGAANEYDDVAGIVVDQEGNVYIAGKSVASWGDPLRPYAGWQDVFLAKFDTNGKLCWNTFVGSKDSDQTAEFGNTLVVDHQGNIYVTGRSYHSWGKPINKHYKAFDTFIAKFTTDGTLLWNTFMGCHDSDVTGGIAIDSMGNTYVTGYSYASWGEPIHPHSSFFISEIFVAKIDSSGKREWNTFMGSTDYDSGFGIAVGQHGVYVSGFSCKTWGNPIRPHVGQGDEGECDIFVAKLDLNGVRQWNTFLGSKNHDDRSYSISVAKDSLFVSGSSWGAWGDPLEPHKGRRDGVLAKLDLKGNMLWHTFIGSQEIESIASIVHKDDKCYIVGSSSTSWASPKTPFSGDYDAYLLVLQLLQLK
>NZ_AP019860.1|WP_151967985.1|3003442_3007561_+|protein-kinase
MSLDHLEFFNIKPQTQINQYQVISQIGSGGMGVVYLVKDALNRKLAMKLIKLERGTAKRRFRREMEISAELQHDNIVKVLDAGAMNKCLYIVMEYIHGKPLDEYWQSLELHEKMVLFHKIAKAVGYAHSKKIVHRDLKPDNILVTPEGEPKIMDFGLAKWANGEVNDLTKDGSLLGTPRYMSPEQLSGKNSLIDMRTDVYALGVILYEMVTNQKMIQGKRRISIFSNIATYNFKPIQEQTEVPKEIENIWRNSVAHRHQRYADAQKMSEDIAHYLTQKKRPFTKRVQRFLRYHSHIIIVAMSVSITLVALYPSFFRDNDKKIIYVNDFVLEAENLINLGFFTEAESALKKAEKYRHSRQKIQLLRLQILFSRGEYTAIIQQNTQAAQHQIEATLLQIKALVRLNASYPVIAQYLQLIYKNDELSALEKQDENTKRLQNLRKIKDEATYHAILFAYHKKMYQKVFELKRYLTPQFRERSYANDLKFYIGESYLQQYKKSQSKTDLQKAYEIFTSIYDLFPEKAQVAYKIGVCLFKLKQPKNAQKYLEVCCQLQPQNSAYRLLLGKAYAATKNYDLANINLKMVRGKEKVKAIEGLFKLVLEDARYQDDVFWFLLRMVALYDEQNLPDLLESDVIELSQKYKVHYREYNNSKKIDGKLFQRYLSVSETRQQAVKAFLLAGYKQDFSHLLHKESLEKKILLRIQKNMRNFIIYLIAHTYLYNTPDIQNLLHKHHRSVEQILHNEKETILIRYLAAKALARIQLYQTVAAAMKSKNSETAVVCSAALSEVNFVFDLRYIGKLNFKLDSRYKAIIYARIFPERHMRYFDLIPRDTTPVSKEHPIYGIVENLRQNLAHEDKVIKVICAALLWRWTGDSELNTILHTVLHEKGPLATFANYYYWKSSYPIDYEDKYFDLLLQILQNSTAKIKHIALNNQNLNQVLLDNPKTKQKFIKALQKLAQEEDLYVKTKASSLIVSTDPKKQQNLYLGKIPLTVKIIVYMLGNLFKVFEIHEISRRGMVTKTSIHDLRNMGFTIMTNRNEPDEFKNFICKTGALFGVSRFKNLKIASSNLGANFLMSATTSYLYSQKTKPFFDLVLGNKSVSKSSLKKLLVPYLQHENPHVRMSAWAAQTYLSNRHQLQKLYQQGQKTEDVYIREGISWGINRFVLNDVMKNVSIQKKSQARAVPYYDIYIDFLRKAKNSHYIPLLRCAAELTNEDIRKAQFHYELAVIHKSLEEPQAIHHINKAIDLIKDLKSSMLDTWVRYQFEKATILSSNIPLHRQEVQSIIEKHLFYINNPDSLTTIATTLAKFQEEKYKDLLKKVLRKQLELLCNKKFKSSDELFQKKYQILQRLITLSENSNPLYNSFFEIIAAKIKK
>NZ_AP019860.1|WP_151967994.1|3018367_3018817_-|MAPEG-family-protein
MLRDNPAFHYWVFLCVFFFFKMFVNSMIQGYSRFRGNHFINPEDTERFADKNKEAMQKYIDRDERAARCWRNDLENIPMFLLLSLALVILGGNPQYCLIYFITYACIRALHTTFYMCAKQPHRGAMFALGIAVTATVAGNCVYLISLTW
>NZ_AP019860.1|WP_151967995.1|3018878_3022013_-|isoleucine--tRNA-ligase
MSFNEVSTQVSFPDEEKKILEFWKKEQVFEKSVEMRSEDKLYSFYDGPPFATGLPHYGHLLAGIIKDIIPRYWTMKGYRVERRFGWDCHGLPVEYEIDKKLDIKGRKGVEEFGIANYNDECKSIVQRYTSEWRQTVERIGRWVDFDNDYKTMNPDFMESVWWVFKQLWEKDLVYRGYKVLPYSTAVATPLSNFEASSNYKDLQDPSITIVFKAIGEENTSFLAWTTTPWTLPSNLALCVGPEIEYVKIKTDKHDDFLIMAKERLKAYFPKNKGFEILETYEGKDLEGKEYEPLFPYFSEKREEGAFKVLVGDHVTIEDGTGIVHTAPAFGEEDFTICQKYNIPVVMPIDDDGQFIEPVSDFLGQHVKAADKNIIKHLKEKKLLYKQDTIQHRVPVCWRSDTPLIYRVISTWFVKVEEIKERIIANNKKTNWIPEHLRDGRFGKWLEGARDWAISRNRFWGNPIPLWMNEETGETLCVGSIAELEELTGKKITDIHRQYIDDLEIPSPTGKKPLKRVSEVLDCWFESGSMPYAQAHYPFENKEKFEKSFPADFIAEGLDQTRGWFYTLSILGTALFDSIPFKNVIVNGILLAEDGNKMSKRLKNYPDPNYVLDEYGADALRLYMIQSPAVRAEDLRFSEAGVKEIVRRVILKTWNAYSFFCNYAAVDKWKPSDKKVETTNLLDKWIVSRMQSLLKRIEEEMAAYRLYNVVPAILDFVEDLTNTYIRFNRKRFWEQGQSDDKEAAYQTLYDVLINLSKVMAPFTPFQAEIIYQNLSQHSADKKESVHLEDFPTAQDESILPSLETSVGIMQQVLVMVRNLREKAKVKVKIPLKRMTIIHRTAEFLENVKELEGYMKEELNIRDIDYSQEEEKYVELQAKANGRVLGKKLGKKFGVINKKIQELSTEELFKLESGKEIEIEGEKITSEGVNVHRTPQPGHEYVASNIHITVEIDATVDEDQMLEGLAREIVNRVQKLRKTADLKLDDNIHIEYSAEKDLQKAIDNHPDYIQEQTLAKSLKQSDEPQGDTSEEYTIDKQKLVLAIKVA
>NZ_AP019860.1|WP_151967996.1|3022014_3022407_-|HIT-domain-containing-protein
MATIFEKIISGDIPCAKVYEDERFLAFLDVRPVNTGHTLVIPKEPHPYIFDLDDETYTDLMKLSKKVAKHLKEKLDCQRVCMTVIGWEVPHVHVHLIPTNEIKELPLNGPNVKKATPDELREIAEKLQGL
>NZ_AP019860.1|WP_151967997.1|3022390_3023113_-|hypothetical-protein
MEKLQLKQSLLACKDHVDREWLQKHSALFVEEHMAKLSQNLLDFHKNGVRDTQPLPHFHVECTPPLSQAFIDFQDALSALQKTQFATTTSNLALLGSCLQKAGCMKILMLLGQRHTPASITDYTAIPPTTELLMSSAFMEGKQGLTIAARAWTKHVGRSDDNFWGEVKGSAQTKNNNARQIVLSILQNTTWWNIFYHYKHALVYEARVSSGHGVRWGKKGEEFIGFLEPFLEEEKNGDNF
>NZ_AP019860.1|WP_151967998.1|3023176_3024427_-|tyrosine--tRNA-ligase
MNAFDVLLERGFIATEDDGTPKQVTDMKIRDILEKKSIACYIGFDPTATSLHVGSLVQIMVLAHMQRAGHRPIALVGGGTAMVGDPSGKSEMRKMLTAEDIEQNMAGLKKQLSRFIEFSDDKAIMVNNADWLSPINYIEFLRDYGVHFSINRMLAAESVKLRLEKEQGLSFLEFNYMLLQAFDFLHLIKNNDCILQMGGDDQWGNICAGIDLIRRVERKTGYGITFPLITTASGAKMGKTEKGAVWLDGDLCSPLDYYQFWRNADDRDVKKFLGLFTFLPMDKVNELGELQGKDINEAKRILAFEATKLNHGEEAAKTAQETVEKIWSGDKKGADIPSLEVESSELEEGILAAELFFKLNLTPSKSEAKRLIKKGGASVNDERIQAFDFKITTSHLQEGEILLRAGKKKYAKVVVK
>NZ_AP019860.1|WP_151967999.1|3024497_3025817_-|6-phosphofructokinase
MSISIQRGKLGILVGGGPAPGINGVIRAVTLEALKRNWEVVGFYDGYQWLSAGNIDDVCEKSAKLTVEDVYKIHFQGGSILRTSRTNPRKIENGVQNCVTMLKEVGIDKMVTIGGDDTVYGAYLLSEEAKKQGLDIQFAHVPKTIDNDLPLPENINTFGFATACHVGATLMKNLMHDAKTTNRWMLAVAMGRHTGHLALGIGKASGATLTIVPEQFENKTITIDDVCDLIQVAMVKCNVRGQNHGVAVIAEGISELLPDEEIEKIPGSKITRDSFGNRRLADVNLALGIRTNLEKRFSELGKSTRLVSVELGYLLRCADPIPQDQIYTKDLGYSAVYFLLNKDDKCQGNVVICLDNGELNPIPFQSIISPETGKSKVRYLNTNSYVYRIAQEYMMHLNDRDLDNTKFLAQMAAELNMNLDDFKERFKHTVFHSPKDISS
>NZ_AP019860.1|WP_151968000.1|3025853_3026792_-|aldo/keto-reductase
MQYNRLGKAGIKVSELSFGSWLTFGKHINVEVAKNCMRAAFEHGVNFFDNAEVYARGLSESVMAQIVKEYRREDLVISTKIFWGGEGPNDKGLSWKHLVEGTKNSLKRLDLEYVDLLFCHRPDPETPIEETVRAMDHIIRSGWAFYWGTSEWSADELQQAYDIAEKYHCIPPTMEQPQYHMFHRERVEEEYASLYENHGLGTTIWSPLASGILTGKYNEGIPENSRLQRESWLAKELTEDKLERVRKLTSLAGDLGCSMAQLAIAWCLVNPNVSTVITGATSVEQVHENMKAIEAKEKLTKEVMDKIDEILN
>NZ_AP019860.1|WP_151968001.1|3026802_3027090_-|hypothetical-protein
MKKILPLILILIFLSGCFSSRTIVGQGVHKTIKEEYTQWYVFWGILPMGKAGNIELNEDIVDARIYVRFTIWDSLFNIFVGPFTSVGRNTVTIEK
>NZ_AP019860.1|WP_151968002.1|3027384_3029562_+|hypothetical-protein
MKKITVFFMCFIFLQSILFAQNETQPKKAENSEKAPVVEKQDKREKKDEEILKTFSKEERELAEESLKAMSDEEKKEALKEIKDNVEKKENVKKDVRKKNKKFIRGVMRKMRGMKDLKDLEKFAKQMKKEWEALPKEKKRKMIHGAMSKIDKMRKKLKQYDTEVKLRKKKDGFSVEIEMNKKKKHHDHGHGHHHAHHGGKKIKNMTLQELKAQLKPWIKKQVSKGCTCKAKAEKAACADSSCNTKAKAKSCCGTCKGQAKAKAKSCCGTCKGQAKAKAKSCCGTCKGQAKAKAKSCCGTCKGQAKKAACADSSCNTKAKAKSCCGTCKGQAKAKAKSCCGTCKGQAKKATCSTKSACSTKSACSTKSACSTKSACSTKAKAKSCCGTCKGKAKAKAKSCCGTCKGKAKHAHKHHAHKHHAHKYHAHKHHAHKHHAHKHHAHKHHAHKHHAHKHHAHKHHGCHSARGYHSKGHGCHAKRGHGCHSARGYHSKGHGCHAKRGHGCHSAHGYHSKGHGCHTKRGHGCHSARGYHKGHGCHAKRGHGYHSAHGYHSKGHGCHTKRGHGCHSARGYHKGHGCHTKRGHGCHSARGYHKGHGCHTKRGHGCHSARGYHKGHGCHTKRGHGYHSAHGHHSKGHGYHRKRGYGYGYHSKGHEHHGSKRHKYKKYQWKQKKSKKHHHKSSFSSQQAELKPEFVNEEVELEIIDTTTDETDIMDEILGELEDELN
>NZ_AP019860.1|WP_173013243.1|3029641_3031030_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MKRKSKVYEEAVIQQKHHKGKFLADVKQKVAVRNAVPGDVVDARIVSRRKKCRQAVIDKVHVLSSVRVSPFCEHFGVCGGCRWQNIGYENQLRYKQDEIGLLFTELTSSQKIQPIISCEQTQYFRNKVNFSFSHARWLTEDELDCDLQHKNGVGFHVSGRYDKVVDLQKCYLQTGPSNDIRLLIRDYAREKNWSFYNIHKNEGFIRSLVIRNTSNNEFMVIVVVAEKDCEEIFPLLQLIQEKFSDVTSIFYAVNLTGNDSLDGVDIIHFWGQHYITEYLNSLQFAIGPRSFFQTNTQQCLRLYEKILDFANFTGQEVVYDLYTGVGSIALFIAKYVQKVVGIDYVEDAIDDARKNATLNDIKNAQFVAGNVQEMLNSDFVEEHGSPEIVIVDPAREGMRKKTCRELIDIAPQKIIYVSCNPKTQVEDLELLAEKYAIEQIQPVDMFPHTHHIENIVLLVKVK

Crispr_ID: NZ_AP019860_15

• CRISPR_ID: NZ_AP019860_15
• CRISPR_location: 3872515-3872636
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_15

Consensus_repeat	Method
ATCCTTGTCTTTCAACAGAAGAATCAAATCAG	CRISPRCasFinder

spacers of NZ_AP019860_15

>15.1|3872547|58|NZ_AP019860|CRISPRCasFinder
GCACTGCTTTCTCTGCTTTTTCTCCCAATGCTTCAATTACAGATCTTCTCACCGATTC

CRISPR arrays and Neighbor proteins around NZ_AP019860_15

CRISPR arrays

The CRISPR arrays of NZ_AP019860_15

>merge|NZ_AP019860|15|3872515-3872636|CRISPRCasFinder
ATCCTTGTCTTTCAACAGAAGAATCAAATCAGGCACTGCTTTCTCTGCTTTTTCTCCCAATGCTTCAATTACAGATCTTCTCACCGATTCATCCTCGTCTTTCAACAGAAGAATCAAATCAG

>NZ_AP019860|15|12|3872515-3872636|CRISPRCasFinder
ATCCTTGTCTTTCAACAGAAGAATCAAATCAG	GCACTGCTTTCTCTGCTTTTTCTCCCAATGCTTCAATTACAGATCTTCTCACCGATTC
ATCCTCGTCTTTCAACAGAAGAATCAAATCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_AP019860.1|WP_151968599.1|3859793_3860252_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968606.1|3864902_3872045_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151968605.1|3864260_3864623_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968602.1|3862963_3863788_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968616.1|3887488_3888238_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271175
NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_AP019860.1|WP_151968601.1|3861716_3862955_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968597.1|3856390_3858229_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968612.1|3884834_3885035_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013313.1|3858197_3859541_-|transglutaminase-family-protein	unknown	unknown	gnl|CDD|224224
NZ_AP019860.1|WP_173013315.1|3873214_3881158_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151968617.1|3888524_3889415_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968604.1|3864021_3864207_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein	unknown	unknown	gnl|CDD|273716
NZ_AP019860.1|WP_151968603.1|3863800_3864013_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968600.1|3860359_3861712_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968615.1|3886714_3887428_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.22312e-05
NZ_AP019860.1|WP_173013315.1|3873214_3881158_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	5.27586e-35
NZ_AP019860.1|WP_151968606.1|3864902_3872045_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	3.04094e-36
NZ_AP019860.1|WP_151968604.1|3864021_3864207_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.62914e-06
NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.88034e-09
NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein	gnl|CDD|273716	TIGR01613, putative_primase, phage/plasmid primase, P4 family, C-terminal domain. This model represents a clade within a larger family of proteins from viruses of bacteria and animals. Members of this family are found in phage and plasmids of bacteria and archaea only. The model describes a domain of about 300 residues, found generally toward the protein C-terminus. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Prophage functions].	1.24869e-59
NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.08088e-09
NZ_AP019860.1|WP_173013313.1|3858197_3859541_-|transglutaminase-family-protein	gnl|CDD|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	6.00291e-08
NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.32916e-27

Protein sequences

>NZ_AP019860.1|WP_151968606.1|3864902_3872045_-|HEAT-repeat-domain-containing-protein
MMGRKYLRYAVILFTLFCLAFAQSKDKNLSERLDKILQQLQLKDARSHLLALVDLEKIGVNAISIQSDLQKLLTNANDKNKKAIEHALDIIKRYLPQQTSQKKFQKTATKRSLASRVSKNLGGLNILGVSNDFRQRLRYGKRHALVIGINKYNKYYPELDGPNYDAGEVASVLSSRYGFENVVYLCDEIPKNVYRRSEIKEKTQNKFTPYGKSYTATYGKETIVETPLITKKVVEGLLTQTFAKVDSNDAIFLFYAGHGVPGHIVATPENKNDNGYISLTKIAKKLSQKNAKHTLMVLDCCFGGSLLQDKYKPKLEGYNNATFQFGTGENIDRVFARRSFQVISAGTGNEVVADKLSTSTKYAQLTDTSGHSPFSAVLLQALKGLVGRDDGIVLTSDLGYYMMTNLTNDKRLDAKQTPRYGSLGGDGDFMFFPAYKVLNPKLLAPLYLSDKVYADFRSSGCEALGKFIDTYSEQDQISLTKSALHHIAKLLEDEEPIPRKTALKFIQDKAQRHVRKIKEFDNVVSALTNYFSYQDEEPKVINLESFFSLKNQKQSEADLYEVVDCLGTLHIYADDKAVDILQKYSKRLKLKWEELSKHKVKLRSVTTKLNKLENLKKLIGGTYQNQAQILQQIIQEYQWLTTSGIQELEFYENRINLFLSNTENPERTKAFDSLKDELEDSDFEKYFKARDQYLRKQVLGYLEKKGKDLDLLFKLFNEENKNIKTDIAKDLEQIGERAFLAIVHELKIDQSQNQISKKLLFAFRSWKKDLLFRLIDQLNQKDQDFFIPVFAEVNFDNLYKTIINRNESNYIKSKAALIIIKSDMEEAFIAKFFLSISERSWIEKQEAIDIIISQEKYIVGNIFLEFLKDEDSNVRSSAAEALGLIGEKAEKAVPALIQALKDEDSEVRNSAVKALGKAGEAEKVIPVLIQALKDEDSEMRNSAAEALGRVGEKAVPALIDALKDQDRSVREYAAKALGMIGEKAEKAVPALIQALKDEDSEVRNSAVKALGKAGEKVEKAVPALIQALKDEDSEVRNSAAKALGKAGEKVEKAVPALIQALKDEDSEVRNSAAKTLGKAGEKAEKAVPTLIQALKDENSDSTARSFAARALGEIGEKAVPALVQALEDKEIEKLAVLRFQDLDSTARSFAARALGMMGEKAEKAVPALIQALKDKNPNIRGSAAKALGEIGEKAVPALIQVINESVRDLTTSTFEKIKKAKSTFEKIKKAKKAKKLERVPIRSPEHSLEILNYAARALGMIGEKAEKAVPALTSALKYKSLNVNYAFRKIGEKAVPALIQALKNEDPIVRRNAACILRFIGRKAEKAVPALIQALEDQDSDVRVRNSAAKALRMIGEKTEKAVPALIQALKDEDPIVRRDAAYILVRIGEKAEKAVPALIDALKDEDLTVRNSAAKALGMIGEKTEKAVPALIQALKDEDSTVRNSAVLALGMIGEKAEKAVPALIQALKDEDSTVRNSAVLALGMIGEKAEKAVPALILALKDEDSTVRRGATEALGMIGEKAEKAVPALIQALKDLDSEVRNSAVRTLVKIGKVENVQILTFLMEDENVFVRSSAAYALSKIVEKTEKVVPALIQALKDEYPIVRRDAAYILGRIGEKAEKAVPALIQALKDEDSTVREYVVKSLGRIGEKAEKAVPALIQALKNEDSTVRRDAAYILGRIGEKAEKAVPALIQALKDEYLEVKNSAAKALGTIGKKAEKAVPALIQVLTDKNFEVRNSAAKALGMIGEKAEKVPALIQVLTDKNFEVRNSVAKALGMIGKKSDKVVPALIQALKDEDSTVRSFAAKVLGIIGEKAEKAEKAVPALIQALKDQDRSVRYYAAKALGRIGEKAEKAVPALIDALKDQDKYVRYHAAEALGKIGEKAEKAVPALIDALKDQDKYVRYYAAEALGKIGEKTEKAVPALIQALKDEDFQVRSSATDSLVRVGEKAVPVLIDALKDKDKYVRYHAAEALGRIGEKAEKAVPALIDALKDQDKYVRYHAAEALGRIGEKAEKAVPALIQALKDEDFQVGSSATDSLARVGEKAVPVLIDALKDQDPNVRYYAAKALEKIVEKAEKAVPALIDRSVKEYAAEALGRVVEKVGKVLPALIQALNDESSTVRMKAAWALCRIGEKAEKAVPALVLALEDEDRIMRSFAAEALGRVGKKAEKAAPALTRALKDKDRIVRRSAANALWRIGEKAVPALIQALKAHNKSVREYAAKVLEKIGEKAEKAVPALTRALKDEDRIVRVSTARALGGIGEKAEKAVPALIDALKDKDFYVRRNAVDALGGIGEKAEKAVPALILALKDEDSTVRRGATEALGKIGEKAELAVSYLTLVLEDEYEDLSVRDYAAQALSKIGEKSLLPIRNLYLKY
>NZ_AP019860.1|WP_151968605.1|3864260_3864623_-|hypothetical-protein
MRYNAAEALGEIGEKALPSIRSLIQNKEDKLGVEALNSYFWNYVYMKEDKKAFSQIDIELLSQLTDKSHLNTVAAIYAWQGNAKEANEYAVKTVKETPRRVKLLLEGKSPKQVEEKMKKE
>NZ_AP019860.1|WP_151968604.1|3864021_3864207_+|helix-turn-helix-domain-containing-protein
MYTVKQVAAWAKVSSGTVVRWIHDGKLRARKNNNGKWRIYKLSSKALLKSRKKNKSTSKKK
>NZ_AP019860.1|WP_151968603.1|3863800_3864013_+|hypothetical-protein
MLSKTVSNLIEYVEQNPEKAQAFVEGINKVWKNRQILINNKEILINGLQGVEQGLANVTSLVNFSLFRKK
>NZ_AP019860.1|WP_151968602.1|3862963_3863788_+|hypothetical-protein
MTICINDSCKTTSSLPENYYKGQLFASDFLFAPKPAIQWRGEGLPVVVVNQKNIDISDFVDLDIQNQNLEEGGSIQPGSLYHLYLDDNGNLLHSALVPTFGKIYATLNGDLQKRYIGSYITDQFGQLLDPITGTGFSGIDEQKRFLKFVSSSQVFTSADNEQTILEVPEFIALKNTKIQFSSHVVFSSDQAGDEIEIRNNMLLNASDRSVSQTAAIANKRFTAANTISKIYNSFAKDHTKLNINFSNTNGNVTIDSGPTTIATRMELLITSPLL
>NZ_AP019860.1|WP_151968601.1|3861716_3862955_+|hypothetical-protein
MSIFIDSSTIVNESEGEQLQNTTTDRMRVSNIVTQFDAQFRYNKQDLLWGESGNNGGGTSIHLPNESSVQMSTGDGNDGSHARRRTNIWFRYQLGIINVIEQAFVFAAGKENLKQQVGIYDDDNGILLQLDNTIAKLILKSSTIGNITIEQQNWNGDKLNGTGESGISIDWTKAQLMRIELQWRGVGAIKIYFQIEDRYILAHTIHNVNMRDSVYMTTANLPLTYEIFNDGAVAGASSMKQLSSTIYSEGGTDANNLKGDLRAGDSGDDFIPTTNTEKAILAIRPKLTFNGITNRGQIWPYDIKFHVADNEECRFIIYIGAQVPDGDWNSVGDDSIAEFNNNMTSFTPGLPLVQEFVLENRSEFSQIAEEFLRSPLVLNEDGTTQTILLITSKNLTGGTASSRCSIKWKEQK
>NZ_AP019860.1|WP_151968600.1|3860359_3861712_+|hypothetical-protein
MYGLQEDTTNVPLMQIEDEEEKFQELQNAIDSCDGYTDAEWEIKKFHPETNGWRRVARIPITESNSTEDLKEKIKMQKWGGAGTYSITLYNNDQTVARASKIKFYIDDIDKEATNTLVDHYKIPTANNQKQDAFQKELHEIQVENLRSMRYQKMKHNLKKEMNEDEPQQPQGGDQLSTMMQMQFNMQQLMLQQQQRQDEIKREDDKRREEQRLRDEQSRQEREARQEEIRLKMIELQMNQQQQNQQMLLQLMHRENPIEKLLLEKTLQDKKDPIMDSIPQFLSMVTGTQQKMQEAGFEILKKNLEKNNILTESEESIRKIAAIREEIIGPAIQALQAWKSSAQQTQYTTTTTKPETRPQVQTQTQTPTQQPEMTSAEKAVREAGTMIMNGKTGEEVWNFILRKLSNEELHELFTSEHTKQQINEALSSLANAGYSAANFILKQAQQNFSE
>NZ_AP019860.1|WP_151968599.1|3859793_3860252_+|hypothetical-protein
MKINTIKKTAIIKKEYTPAHCWICNEEIVLQRCHEKQYFAKFHCKKCFSRGFIHASKYKEYITTTYDKGEVKIDSYEAQNFGEIQIAALTECPICLGMSLRVKKCTRKLKQKGKRGRPRRVVGNAYFCNCKECRFTSFVNKGLGRYIYYHNY
>NZ_AP019860.1|WP_173013313.1|3858197_3859541_-|transglutaminase-family-protein
MDLDIIRLARGICSEWHANSKNAREKADAIHDWIAENIHYQFDPVTTELYQDSKTTLKEGFGDCDDFVILGMALNAAVGNYSRAVLIAADNEVQIDHVYYEVEVGENEWRAYDATVNGAEAGWKPKPEVVRHYVYLDGSVGTGFFGKIFKELSRFFRKFEKNVIRRPIKEIKRFAEKNFKDIYQPISRLARKIRDERRRLFEKIAKGLDDLTEDLGPFGGIAQTVIKAAAAIVVSQVAGALARSLFMQGNSGINAIASGASRVAVSPMIVENATFSALTIPEGSPLEMSAEEWGVLLSIAMTILSAGAAAVGNVALVAVTQIAQTAKTAIDVQNAIDEKEKLLDELKQIKAQVLAQAQAQQEVILKLEKDIEILRKFQQLHEEYELKIKQFRDENNQEIKNFTAEMEIASQKRIELHKADIEQRKLQIQLLAQKVARDAENSASVAV
>NZ_AP019860.1|WP_151968597.1|3856390_3858229_-|hypothetical-protein
MQKIQLPLPFSQTNIRYKEEPSIGRQYLRHERITEHRVSRKEQTYVPFMEEVLQKAISADFSEDRPQDEIEVETKAVAEYDNWITFSSVPMKVFKRPHGGAGFHKRSRKLQRMIYEMSNVNTKLEWRNEIEYKRDLKKIVRKLLAYANAKYILSELRKGKSLAELLLPIESVWVGDLADLVNERLQLVIDNEALFREQDDKFIADFAVAYSAMYYSQKLEESDGKGAFYVFIPKLFRCCSQIERLTANLNEYASLIPVSMPFSKYYIAGAPHFKVIQIPFYKIDLLQGTSSGRKNVQIMNDPATMRLVMQKEVRFHFLMQKLLHKFITINLEESRTTQKIEEEIVAQVERYKVGARIALFSGRNMFSYRKTHEFFSLAIQTLGRSIEKHKLATCNANKNNYFATLPSLEETPYFNSDQVQRSNENIDKFKEAYHHFVSDVKIDSNYDDLERDIAAKIAFFLLCQMAVDKSFVASMFANAMKDINDLQHFWKISNENKKNLAAEIDQQNALRAQELQEENQAAFENDLEDQLAVEFGENRRAVYDQEYAKLEQDLLGRYDALLGELQTANERRKEVIEKQVFAKETLEVMRLEKEFANEMKVLLGEIRKAKHA
>NZ_AP019860.1|WP_173013315.1|3873214_3881158_-|HEAT-repeat-domain-containing-protein
MIGKTYLQHAIILFVLFNLAFTQSEDKNLNARLKTIVKQLQSSNAQLRFSALAELEKLGTATKAIRPNLEKALNQANGRSKLAIMHAIGIIDQLKNKKDSDQYITKKIATKRSLASRVSKNLGGLNILGVSNDFRQRLRYGKRHALVIGINKYNKYYPELDGPNYDAGEVASVLSSRYGFENVVYLCDEIPKNVYRRSEIKEETQNKFTPYGKSYTATYGKETIVETPLITKKVVEGLLTQTFAKVDSNDAIFLFYAGHGVPGHIVATPEHKNDNGYISLTKIAKKLSQKNAKHTLMVLDCCFGGSLLQDQYKPKLEGYNNATFQFGTGENIDRVFARRSFQVISAGTGNEVVADKLSTSTKYAQLTDTSGHSPFSAVLLQALKGLVGRDDGIVLTSDLGYYMMTNLTNDKRLDAKQTPRYGSLGGDGDFMFFPAYKVLNPKLLAPLYLSDKVYADFRSSGCEALGKFIDTYSEQDQISLTKSALHHIAKLLEDEEPIPRKTALKFIQEKAQRHVRKIKEFDNVVSALTNYFSYEDEEPKVINLESFFSLKNLKQSEADLYEVVDCLGTLHIYADDKAVDILQKYSKRLKLKWEELSKDRVKPRSVTVKLNKLENLEKLIGGTYQNQALILHQIIQEYQWLTTSGIQELEFYENRMNLFLSNTENSERTKAFDSLKSEFEDSDFEKYFKVRDQYLRKQVLGYLEKKGKDLDLLFKLFNEENENIKTDIAKDLEIIGKRAFLAIVNELKTDQSQNQISKKLLFAFHRWKKDSLFGLIDQLNQKDQDFFIPVFAEANFDNLYEVIINRNQSNDVRSKAAFIIMKSDMKEAFIAKFFLSLSERSVFEKQRAIDIITSQEKYLVVKIFLELLKDKNLNVRGSAAEALGKMGEKAEKAVPALILALKDQVPNVRRGATEALGEIGEKAEEAVPALILALKDQVPNVRRGATEALGEIGEKAEEAVPALILALKDQVPNVRRGATEALGEIGEKAEEAVPALILALKDLYPNVRRGATEALGEIGEKAEEAVPALILALKDVYPSVYRGATEALGKIGEKAEKAVPALILALKNQSPYVRRGATEALGEIGEKAEEAVPALILALKDESNDVRKNATNALSEVGEKAIPALILAIKDESNDVRKNATNALSKVGEKAILALILALKDENNDVRAQAARALGEIGEKAEKAVPALILALKDQNDVRAQAARALGEIGEKAEKAVPALILALKGQNNDVRTQAARALGEIGEKAEKAVPALILALKDQNNYVRNQAARALGRIGKKEEKAVPVLIDALKNQSPYVRSSAAKALGEIGEKAEKAVPVLIDALKDLDDGVRCYAAEALGEIGEKAEKAVPVLIDALKDLDDGVRCYAAEALGEIGEKAKKAVPALIIALKDQDGSVRRSAATALGMIGEKAEKSVSALIIALKDQYPDVRESVAEALGGIGEKAEKSVSALIIALKDPYFDVRRSAAKALVKIEGKAEKAVPALIDVLKDQNENIRISAAEALGKIGEKAEKAEKAEKAEKAEKAEKAEKAEKAEKAVSAFIIALKDQDINVGISAAETLGKIKEVENVEFLTFLIKAQEENVRKFVAWALGEIGEKAEKAVPALILALKDQDGSVRKFVARALGEIGEKAEKAVPALILALKDQDGSVRKFVAWALGEIGEKAEKAVPALILALKDQDENIRISAAEALGKIGEKAEKAVPALILALKDQDINVGISAAEALGKIGEVENVELLTFLIKDQDENVRRSAASALGKIGEKAVPALTITLKDPYFDVRESVAEALGGIGEKAEKAVPALILALKDQNNYVRKNATNALSKVGEKAIPALILALKDQNNYVRKNATNALSKVGEKAIPALILALKDQNNDVRKNAARALGEIGEKAEKAAPALIIALKDQNDDVRKNAARALGEIGEKTEKAVPALILALKDQNNDVRESVAEALGKIVGEKAEKAVPALIIALKDQNENIRKNAARALGKIGEKAEKAAPALILALKDQNKHVRTEAVWALREIGEKAEKVVPALILNFKDPDYYVRMYSSSVLVKIGEKAVPALIIALKDQNDDVRKNAARALGRIGEKAEKAVPALILALKDQNKHVRTEAVWALREIGEKAEKAVPALILALKDQNDDVRTQAAWALGGIGEKAVPTLIDALKDQDGSVRRGATEALGEIGEKAERAVPALIDALKDQDGSVRRGATEALGEIGEKAEKAVPALIDALKDQDGSVRRGATEALGEIGEKAEKAEKAVPALIYALKDQNNEVRTEAVWALGKIGEKAGKAVPALILTLKDQSNYVRTQAVRALGKIGKKAEKAVPALILALKDRNNDIRTEAAWALGEIGEKAVKAVPALILTLKDLDDWVRTQAARTLGEIGEKAEKAVPALILALKDRNNDIRTEAAWALGEIGEKVGKAVPALILTLKDQYPDVRESAAEALGKIGEKAVPALILALKDLDDWVRTQAARTLGEIGEKAEKAVPALILALKDQNNEVRTQAAWALGEIREKAGKAVPALILTLKDQYPDVKKSAAEALGKIGEKALPSIRSFIQNKEDKLVIELGLEALNYYFWDYVYMNENKKAFSQIDIELLSQSTDKYHLNTVAAIYAWQGSAKEANEYAVKAVKKTPKRVKLLLEGKSPKQVEEKMKKE
>NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein
MNIGELINLGLTKKKMSQKELANLVGVNPPAVTKWISGKNSPPADKLIKIISLLNLTEEFFPERKQELEKLDKETNQINARLEKLESLFEQDAHENNKKKIQALEAENAMLRAAIGDFDRQELIESMHLLRSFDYDALREASNLIEEFGSAILKKAAKNLTRKKVKQA
>NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein
MNLGNTIRNRRKQLKISQKELARLMECGSSLVCKWESGKIIPNFEQIQKLEVLLSMGVLSEEFCHRRAIL
>NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein
MATELLEYSISDLQRSGLNQETIQRMRVYSLARKKTDWLKENLGFAKYDGQNLAQVTSEIMVIPYQQDFVRVKLFPQLQGAKYLSPKKGGCWLYYLDGEEKKFHKAKKPIILTEGEKKCAKLTQEIGDDFLCLGSAGISTWNTRDWQSITLKGREVYIAFDRPNERNPDEEKQLLSLFLFLWKRGAIVYFLHWPEEYEKVDDWLTAVSSPQMALKTALDESKCNDNCFTEIAAVNHLYLAQKLEAFKYDKNDITILWDRFKVRKHTAIGKGMIKAMVEKCRVDAIREESPEWIEVSERGKQSVIPGLLAKTVLAEYGDGLIFHQSTFWTYDKSSGIWVEEPENGRRIKAFIQHKLGDKLCRKSIVEDVYFQIQNYAVQQQLGFDFDKNKQFLNLQNGVLDLTSMEMREHDKDLYFTSKVNTNYVPEADCPKWKTFLWETELDEATLMRLQEWFGYCLIPDTRIEKALYLMGPGGNGKTVIVETLQALLKEYSCSLDLSEIFGRFNTAKLRNKMVNICSDNKTTIPIDDRVKNLISGGRLHGEFKGRDGFYFDNYARLVFAANDFIPTKDRSHGFYRRFDIIEIAKTWSEEERNENLKYEIWEEELPGVLNWALEGLQRLQDNNFKMTKSQAMNNTMKEFREYSNPLLQFVNDCCEIQEGNDVLCMDLYEQYALWCSSSGHKCYSASKMGKELKKIAPKIVKKKLSIKNENGFRPNYYTGIKLIARKWTEQNTQEIYNYIYCGQT
>NZ_AP019860.1|WP_151968612.1|3884834_3885035_+|hypothetical-protein
MAIKCKPPAHIQKQIKCPRKLVAKLYRKGIDLGYSLQELDYIMSAKHGLFTWLDGEELWRFFHENE
>NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein
MVGVLQVEELLKQKIQDLEKRLRKIEAGKSAPNADCLTKKEAMEWLGCSKETLNRYIDSGQLPILWPNAKKCLHPEDVKAYMRGMRPNRRRRK
>NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase
MESNFARGTDFNKDITIEYIVEHYLEKAKYTMKERSYLVEKQCVEKVIEYFHLKGLIYFRLLTPKSLQDFIVWRKETITPRGKPPSNVTVNKNIAAIKRALNLASKNQLIPQDPFANVSLIRVDKEDSPRIFSKEDIRIIEQMAEKSTIKSEIFFLVRTGLRVSEMVNLEIADVDLGKNIIIVRSVKAKSRKTRYVPIVKGLGIKLQELLNEAKANQRSLVFVNSQGNKHCLRNILRRFRTILKNAKKYGVDIEGVNIHSLRKTYISHMIMSGQDPVKVMKIVGHQSWETMKKYLFLTEEYLQDVPSLF
>NZ_AP019860.1|WP_151968615.1|3886714_3887428_-|hypothetical-protein
MMQSTPIIIVLIFCFTIPLAAQNQSFERESTNIIEQIVKQNNQNQSLEDKELLERYRNNIGGTSSIQIEKSWRFDKYLRDRTQKSQNESNRRVSTEKTSTKRINEIAKDKEKKKNKQDKLKSKHRKHRFKMNTHINSQEEIKRGYVNEKGFCYAPRPNYGRVVRIDGHSEKKYTVTKRTKEECFTVGTIFYSKTTCDITDLKTGKKTRTVKTCKGVHLSTGTPLYGATRTSVYCEKE
>NZ_AP019860.1|WP_151968616.1|3887488_3888238_-|hypothetical-protein
MKVTFILIMVAFISSTQCQEIFDDIKGLENPYVRESFAAENDFIGYEVDKCLERTKLAYKNFPLPSLEKTVTIDIVKKYKIENEDGEKSVEKTSTTEKKVVRQVLTMSIGSYSQLNLKITVSDKTTFDNCLVIYDLTSQGTPKILSTYRSKDNIFRSLDQKFRKENRDREKKTFSYKNNEAFPKVIGLVLISRRAKNYLDMGKYEWKPVPLDSNHLMILGEGVIGFDDYVYKGYRSVIVQYYYQQVVNN
>NZ_AP019860.1|WP_151968617.1|3888524_3889415_+|hypothetical-protein
MENSLNNAESEFPLKAVDYEDIREIDGQDTRQSITIRNYNLVSETAKIYRWKINELVNYSLEIYFAFLDIDLENKSVTESQSFMRLKEYAKSYYIEEKEAIRYAIDIFSGLYTNNSLVKIQSHQLVKGNKRTVQGIISELLSEYLKDDTNIKNRKDNSKKISIKTKRVEISRFAKNKSSERKSITIKNHNVIRTVAEFYRWTINELVNYSLEIFLSLLDINIKKEQVIESVSFSRLKEFAQVHGMQEGQTIRYAINIFSRLYHDGIFKKIQSSSLEEKSIKKAIPLLVTDSLKNFF

Crispr_ID: NZ_AP019860_16

• CRISPR_ID: NZ_AP019860_16
• CRISPR_location: 3873615-3875523
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 19 spacers

Consensus repeat of NZ_AP019860_16

Consensus_repeat	Method
NNNNNNNNNANAATNAGAGCTGGNACNGCTTTNTCNGCTTTTTCTCCTATTT	CRT

spacers of NZ_AP019860_16

>16.1|3873658|56|NZ_AP019860|CRT
CCCCCAATGCCCATGCTGCCTGGGTTCTAACTTCATTATTCTGGTCTTTTAGTGCA
>16.2|3873757|56|NZ_AP019860|CRT
CCCCCAACGTCCGTGCTGCCTGGGTTCTAACCCAATCATCCAGATCTTTTAGAGCA
>16.3|3873856|47|NZ_AP019860|CRT
CCTCTGCTGCAGATTCTCTCACATCAGGGTATTGATCTTTTAGAGTA
>16.4|3873946|56|NZ_AP019860|CRT
CCCCCAATGCCCATGCTGCCTCGGTTCTAATGTCATTATTCCGGTCTTTTAGTGCA
>16.5|3874045|56|NZ_AP019860|CRT
CCCCCAACGTCCGTGCTGCCTGGGTTCTAACCCAATCATCCAGATCTTTTAGAGTA
>16.6|3874144|56|NZ_AP019860|CRT
CCCCCAATGCCCATGCTGCCTCGGTTCTAATGTCATTATTCCGGTCTTTTAGTGCA
>16.7|3874243|56|NZ_AP019860|CRT
TTCCCAATGCCCTTACTGCCTGGGTTCTAACATAATTACTCTGGTCTTTTAGAGTA
>16.8|3874342|56|NZ_AP019860|CRT
TTCCCAATGCCCATACTGCCTCGGTTCTAACTTCATTATTCTGGTCTTTTAGAGCA
>16.9|3874441|65|NZ_AP019860|CRT
CTCCTATCTCTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCA
>16.10|3874549|56|NZ_AP019860|CRT
CTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCA
>16.11|3874648|56|NZ_AP019860|CRT
CTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCA
>16.12|3874747|47|NZ_AP019860|CRT
CCCATGCTGCCTGGGTTCTAACGTCGTCATTCTGGTCTTTTAGTGCA
>16.13|3874837|56|NZ_AP019860|CRT
CCCTCAATGCCCATACTGCCTCGGTTCTAACGTGCTTATTCTGGTCTTTGAGAGCG
>16.14|3874936|47|NZ_AP019860|CRT
TTCCCAATGCCCTTGCTGCATTTTTTCTAACGTCGTCATTCTGGTCT
>16.15|3875026|56|NZ_AP019860|CRT
TAACTAACACACTTGATGAATACATTCTAACATAATAATCTGGGTCTTTGAAATTA
>16.16|3875125|56|NZ_AP019860|CRT
CCCTCAATGCCCATACTGCCTCGGTTCTAACGTGCTTATTCTGGTCTTTGAGAGCG
>16.17|3875224|56|NZ_AP019860|CRT
TACCTAACGCCCTTGCTGCATTTTTTCTAATATTTTCATTCTGGTCTTTGAGAGCA
>16.18|3875323|59|NZ_AP019860|CRT
TTTTCCCCAATGCCTCTGCTACAGATTCTCTCACATCATTATTCTGGTCTTTTAGTGCA
>16.19|3875425|56|NZ_AP019860|CRT
CCCCCAATGCCCTTGCTGCATTTTTTCTAACGTCGTCATTCTGGTCTTTGAGAGCA

CRISPR arrays and Neighbor proteins around NZ_AP019860_16

CRISPR arrays

The CRISPR arrays of NZ_AP019860_16

>merge|NZ_AP019860|16|3873615-3875523|CRT
AGAATGAGAGCTGGTACTGCTTTACCTGCTTTTTCTCTTATTTCCCCCAATGCCCATGCTGCCTGGGTTCTAACTTCATTATTCTGGTCTTTTAGTGCAAGAATGAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTATTTCCCCCAACGTCCGTGCTGCCTGGGTTCTAACCCAATCATCCAGATCTTTTAGAGCAAGAATGAGAGCTGGTACTGCTTTTTCTCCTATTTTACCTAATGCCTCTGCTGCAGATTCTCTCACATCAGGGTATTGATCTTTTAGAGTAAGAATGAGAGCTGGTACTGCTTTACCTACTTTTTCTCCTATTTCCCCCAATGCCCATGCTGCCTCGGTTCTAATGTCATTATTCCGGTCTTTTAGTGCAAGAATGAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTATTTCCCCCAACGTCCGTGCTGCCTGGGTTCTAACCCAATCATCCAGATCTTTTAGAGTAAGAATGAGAGCTGGTACTGCTTTAACTGCTTTTTCTCCTATTTCCCCCAATGCCCATGCTGCCTCGGTTCTAATGTCATTATTCCGGTCTTTTAGTGCAAGAATGAGAGCTGGCACTGCTTTTTCCGCTTTTTTTCCTATTTTTCCCAATGCCCTTACTGCCTGGGTTCTAACATAATTACTCTGGTCTTTTAGAGTAAGAATGAGAGCTGGTACTGCTTTACCTGCTTTTTCTCCTATTTTTCCCAATGCCCATACTGCCTCGGTTCTAACTTCATTATTCTGGTCTTTTAGAGCATAAATAAGAGCTGGTACTGCTTTCTCTGCTTTCTCTGCTTTCTCTCCTATCTCTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCATCAATAAGAGCTGGTACTGCTTTCTCTGCTTTCTCTCCTATCTCTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCATCAATAAGAGCTGGTACTGCTCTCTCTGCTTTCTCTCCTATCTCTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCATCAATAAGAGTTGGTACTGCTTTTTCTCCTATTCCTCCCAATGCCCATGCTGCCTGGGTTCTAACGTCGTCATTCTGGTCTTTTAGTGCAAGAATGAGAGCTGGCACTGCTTTTTCCGCTTTTTCTCCTATTTCCCTCAATGCCCATACTGCCTCGGTTCTAACGTGCTTATTCTGGTCTTTGAGAGCGAGAATAAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTATTCTTCCCAATGCCCTTGCTGCATTTTTTCTAACGTCGTCATTCTGGTCTTTGAGAGCAATAATAAGAGCTGGTACTGCTTTTTCTCCTATTTTAACTAACACACTTGATGAATACATTCTAACATAATAATCTGGGTCTTTGAAATTAAGAATGAGAGCTGGCACCACTTTTTCCGCTTTTTCTCCTATTTCCCTCAATGCCCATACTGCCTCGGTTCTAACGTGCTTATTCTGGTCTTTGAGAGCGAGAATAAGAGCTGGCGCCGCTTTTTCCGCTTTTTCTCCTATTTTACCTAACGCCCTTGCTGCATTTTTTCTAATATTTTCATTCTGGTCTTTGAGAGCAATAATGAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTACTATTTTCCCCAATGCCTCTGCTACAGATTCTCTCACATCATTATTCTGGTCTTTTAGTGCAAGAATGAGAGCTGGCACCGCTTTTTCCGTTTTTTCTCCTATTTCCCCCAATGCCCTTGCTGCATTTTTTCTAACGTCGTCATTCTGGTCTTTGAGAGCAATAATGAGAGCTGGCGCCGCTTTTTCCGCTTTTTCTCCTATTT

>NZ_AP019860|16|3|3873615-3875523|CRT
AGAATGAGAGCTGGTACTGCTTTACCTGCTTTTTCTCTTATTT	CCCCCAATGCCCATGCTGCCTGGGTTCTAACTTCATTATTCTGGTCTTTTAGTGCA
AGAATGAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTATTT	CCCCCAACGTCCGTGCTGCCTGGGTTCTAACCCAATCATCCAGATCTTTTAGAGCA
AGAATGAGAGCTGGTACTGCTTTTTCTCCTATTTTACCTAATG	CCTCTGCTGCAGATTCTCTCACATCAGGGTATTGATCTTTTAGAGTA
AGAATGAGAGCTGGTACTGCTTTACCTACTTTTTCTCCTATTT	CCCCCAATGCCCATGCTGCCTCGGTTCTAATGTCATTATTCCGGTCTTTTAGTGCA
AGAATGAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTATTT	CCCCCAACGTCCGTGCTGCCTGGGTTCTAACCCAATCATCCAGATCTTTTAGAGTA
AGAATGAGAGCTGGTACTGCTTTAACTGCTTTTTCTCCTATTT	CCCCCAATGCCCATGCTGCCTCGGTTCTAATGTCATTATTCCGGTCTTTTAGTGCA
AGAATGAGAGCTGGCACTGCTTTTTCCGCTTTTTTTCCTATTT	TTCCCAATGCCCTTACTGCCTGGGTTCTAACATAATTACTCTGGTCTTTTAGAGTA
AGAATGAGAGCTGGTACTGCTTTACCTGCTTTTTCTCCTATTT	TTCCCAATGCCCATACTGCCTCGGTTCTAACTTCATTATTCTGGTCTTTTAGAGCA
TAAATAAGAGCTGGTACTGCTTTCTCTGCTTTCTCTGCTTTCT	CTCCTATCTCTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCA
TCAATAAGAGCTGGTACTGCTTTCTCTGCTTTCTCTCCTATCT	CTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCA
TCAATAAGAGCTGGTACTGCTCTCTCTGCTTTCTCTCCTATCT	CTCCCAATGCCTCCGTTGCACCTCTTCTCACACTTCCATCCTGGTCTTTTAGAGCA
TCAATAAGAGTTGGTACTGCTTTTTCTCCTATTCCTCCCAATG	CCCATGCTGCCTGGGTTCTAACGTCGTCATTCTGGTCTTTTAGTGCA
AGAATGAGAGCTGGCACTGCTTTTTCCGCTTTTTCTCCTATTT	CCCTCAATGCCCATACTGCCTCGGTTCTAACGTGCTTATTCTGGTCTTTGAGAGCG
AGAATAAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTATTC	TTCCCAATGCCCTTGCTGCATTTTTTCTAACGTCGTCATTCTGGTCT
TTGAGAGCAATAATAAGAGCTGGTACTGCTTTTTCTCCTATTT	TAACTAACACACTTGATGAATACATTCTAACATAATAATCTGGGTCTTTGAAATTA
AGAATGAGAGCTGGCACCACTTTTTCCGCTTTTTCTCCTATTT	CCCTCAATGCCCATACTGCCTCGGTTCTAACGTGCTTATTCTGGTCTTTGAGAGCG
AGAATAAGAGCTGGCGCCGCTTTTTCCGCTTTTTCTCCTATTT	TACCTAACGCCCTTGCTGCATTTTTTCTAATATTTTCATTCTGGTCTTTGAGAGCA
ATAATGAGAGCTGGCACCGCTTTTTCCGCTTTTTCTCCTACTA	TTTTCCCCAATGCCTCTGCTACAGATTCTCTCACATCATTATTCTGGTCTTTTAGTGCA
AGAATGAGAGCTGGCACCGCTTTTTCCGTTTTTTCTCCTATTT	CCCCCAATGCCCTTGCTGCATTTTTTCTAACGTCGTCATTCTGGTCTTTGAGAGCA
ATAATGAGAGCTGGCGCCGCTTTTTCCGCTTTTTCTCCTATTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151968599.1|3859793_3860252_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968606.1|3864902_3872045_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_173013316.1|3890157_3890910_-|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|379155
NZ_AP019860.1|WP_151968605.1|3864260_3864623_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968602.1|3862963_3863788_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968616.1|3887488_3888238_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_AP019860.1|WP_151968601.1|3861716_3862955_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013313.1|3858197_3859541_-|transglutaminase-family-protein	unknown	unknown	gnl|CDD|224224
NZ_AP019860.1|WP_151968612.1|3884834_3885035_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271175
NZ_AP019860.1|WP_173013314.1|3872055_3872928_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293787
NZ_AP019860.1|WP_151968617.1|3888524_3889415_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968604.1|3864021_3864207_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein	unknown	unknown	gnl|CDD|273716
NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_AP019860.1|WP_151968603.1|3863800_3864013_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968600.1|3860359_3861712_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968615.1|3886714_3887428_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.22312e-05
NZ_AP019860.1|WP_173013314.1|3872055_3872928_-|HEAT-repeat-domain-containing-protein	gnl|CDD|293787	sd00044, HEAT, HEAT repeats. The canonical HEAT repeat consists of two helices forming a helical hairpin. HEAT repeats are found in a diverse family of proteins, including the four proteins from which its name is based: Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A (PP2A), and the lipid kinase TOR (target of rapamycin). The HEAT repeat family is related to armadillo (ARM)/beta-catenin-like repeats.	2.62872e-18
NZ_AP019860.1|WP_151968606.1|3864902_3872045_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	3.04094e-36
NZ_AP019860.1|WP_151968604.1|3864021_3864207_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.62914e-06
NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.88034e-09
NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein	gnl|CDD|273716	TIGR01613, putative_primase, phage/plasmid primase, P4 family, C-terminal domain. This model represents a clade within a larger family of proteins from viruses of bacteria and animals. Members of this family are found in phage and plasmids of bacteria and archaea only. The model describes a domain of about 300 residues, found generally toward the protein C-terminus. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Prophage functions].	1.24869e-59
NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.08088e-09
NZ_AP019860.1|WP_173013316.1|3890157_3890910_-|PEP-CTERM-sorting-domain-containing-protein	gnl|CDD|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	1.3496e-18
NZ_AP019860.1|WP_173013313.1|3858197_3859541_-|transglutaminase-family-protein	gnl|CDD|224224	COG1305, COG1305, Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism].	6.00291e-08
NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.32916e-27

Protein sequences

>NZ_AP019860.1|WP_173013314.1|3872055_3872928_-|HEAT-repeat-domain-containing-protein
MPDLILLLKDERPNEINSVIEALGGIGKIGEKAVPALILALKNQDKSVKSSAVKVLGNIGEKAVPALILVLNSQDQRARLFAIEALGKIGEKAEKAVSDLILLLKDEDESVRRSVIEALGEKAEKAVPDLILLLKDKDSYLRSSVIKALGEKARKALPALILALKDQSWEVRRSAAWVLGKIGEKALPSIRSFIQNKEDKLGLEALNSYFWDYVYIKESKKAFSQIDIELLSQSTDKNHLDTVAAIYAWQGNRKKANDYAVKALEKTTKRLKLLLEGKSLKQVEEEMRKK
>NZ_AP019860.1|WP_151968606.1|3864902_3872045_-|HEAT-repeat-domain-containing-protein
MMGRKYLRYAVILFTLFCLAFAQSKDKNLSERLDKILQQLQLKDARSHLLALVDLEKIGVNAISIQSDLQKLLTNANDKNKKAIEHALDIIKRYLPQQTSQKKFQKTATKRSLASRVSKNLGGLNILGVSNDFRQRLRYGKRHALVIGINKYNKYYPELDGPNYDAGEVASVLSSRYGFENVVYLCDEIPKNVYRRSEIKEKTQNKFTPYGKSYTATYGKETIVETPLITKKVVEGLLTQTFAKVDSNDAIFLFYAGHGVPGHIVATPENKNDNGYISLTKIAKKLSQKNAKHTLMVLDCCFGGSLLQDKYKPKLEGYNNATFQFGTGENIDRVFARRSFQVISAGTGNEVVADKLSTSTKYAQLTDTSGHSPFSAVLLQALKGLVGRDDGIVLTSDLGYYMMTNLTNDKRLDAKQTPRYGSLGGDGDFMFFPAYKVLNPKLLAPLYLSDKVYADFRSSGCEALGKFIDTYSEQDQISLTKSALHHIAKLLEDEEPIPRKTALKFIQDKAQRHVRKIKEFDNVVSALTNYFSYQDEEPKVINLESFFSLKNQKQSEADLYEVVDCLGTLHIYADDKAVDILQKYSKRLKLKWEELSKHKVKLRSVTTKLNKLENLKKLIGGTYQNQAQILQQIIQEYQWLTTSGIQELEFYENRINLFLSNTENPERTKAFDSLKDELEDSDFEKYFKARDQYLRKQVLGYLEKKGKDLDLLFKLFNEENKNIKTDIAKDLEQIGERAFLAIVHELKIDQSQNQISKKLLFAFRSWKKDLLFRLIDQLNQKDQDFFIPVFAEVNFDNLYKTIINRNESNYIKSKAALIIIKSDMEEAFIAKFFLSISERSWIEKQEAIDIIISQEKYIVGNIFLEFLKDEDSNVRSSAAEALGLIGEKAEKAVPALIQALKDEDSEVRNSAVKALGKAGEAEKVIPVLIQALKDEDSEMRNSAAEALGRVGEKAVPALIDALKDQDRSVREYAAKALGMIGEKAEKAVPALIQALKDEDSEVRNSAVKALGKAGEKVEKAVPALIQALKDEDSEVRNSAAKALGKAGEKVEKAVPALIQALKDEDSEVRNSAAKTLGKAGEKAEKAVPTLIQALKDENSDSTARSFAARALGEIGEKAVPALVQALEDKEIEKLAVLRFQDLDSTARSFAARALGMMGEKAEKAVPALIQALKDKNPNIRGSAAKALGEIGEKAVPALIQVINESVRDLTTSTFEKIKKAKSTFEKIKKAKKAKKLERVPIRSPEHSLEILNYAARALGMIGEKAEKAVPALTSALKYKSLNVNYAFRKIGEKAVPALIQALKNEDPIVRRNAACILRFIGRKAEKAVPALIQALEDQDSDVRVRNSAAKALRMIGEKTEKAVPALIQALKDEDPIVRRDAAYILVRIGEKAEKAVPALIDALKDEDLTVRNSAAKALGMIGEKTEKAVPALIQALKDEDSTVRNSAVLALGMIGEKAEKAVPALIQALKDEDSTVRNSAVLALGMIGEKAEKAVPALILALKDEDSTVRRGATEALGMIGEKAEKAVPALIQALKDLDSEVRNSAVRTLVKIGKVENVQILTFLMEDENVFVRSSAAYALSKIVEKTEKVVPALIQALKDEYPIVRRDAAYILGRIGEKAEKAVPALIQALKDEDSTVREYVVKSLGRIGEKAEKAVPALIQALKNEDSTVRRDAAYILGRIGEKAEKAVPALIQALKDEYLEVKNSAAKALGTIGKKAEKAVPALIQVLTDKNFEVRNSAAKALGMIGEKAEKVPALIQVLTDKNFEVRNSVAKALGMIGKKSDKVVPALIQALKDEDSTVRSFAAKVLGIIGEKAEKAEKAVPALIQALKDQDRSVRYYAAKALGRIGEKAEKAVPALIDALKDQDKYVRYHAAEALGKIGEKAEKAVPALIDALKDQDKYVRYYAAEALGKIGEKTEKAVPALIQALKDEDFQVRSSATDSLVRVGEKAVPVLIDALKDKDKYVRYHAAEALGRIGEKAEKAVPALIDALKDQDKYVRYHAAEALGRIGEKAEKAVPALIQALKDEDFQVGSSATDSLARVGEKAVPVLIDALKDQDPNVRYYAAKALEKIVEKAEKAVPALIDRSVKEYAAEALGRVVEKVGKVLPALIQALNDESSTVRMKAAWALCRIGEKAEKAVPALVLALEDEDRIMRSFAAEALGRVGKKAEKAAPALTRALKDKDRIVRRSAANALWRIGEKAVPALIQALKAHNKSVREYAAKVLEKIGEKAEKAVPALTRALKDEDRIVRVSTARALGGIGEKAEKAVPALIDALKDKDFYVRRNAVDALGGIGEKAEKAVPALILALKDEDSTVRRGATEALGKIGEKAELAVSYLTLVLEDEYEDLSVRDYAAQALSKIGEKSLLPIRNLYLKY
>NZ_AP019860.1|WP_151968605.1|3864260_3864623_-|hypothetical-protein
MRYNAAEALGEIGEKALPSIRSLIQNKEDKLGVEALNSYFWNYVYMKEDKKAFSQIDIELLSQLTDKSHLNTVAAIYAWQGNAKEANEYAVKTVKETPRRVKLLLEGKSPKQVEEKMKKE
>NZ_AP019860.1|WP_151968604.1|3864021_3864207_+|helix-turn-helix-domain-containing-protein
MYTVKQVAAWAKVSSGTVVRWIHDGKLRARKNNNGKWRIYKLSSKALLKSRKKNKSTSKKK
>NZ_AP019860.1|WP_151968603.1|3863800_3864013_+|hypothetical-protein
MLSKTVSNLIEYVEQNPEKAQAFVEGINKVWKNRQILINNKEILINGLQGVEQGLANVTSLVNFSLFRKK
>NZ_AP019860.1|WP_151968602.1|3862963_3863788_+|hypothetical-protein
MTICINDSCKTTSSLPENYYKGQLFASDFLFAPKPAIQWRGEGLPVVVVNQKNIDISDFVDLDIQNQNLEEGGSIQPGSLYHLYLDDNGNLLHSALVPTFGKIYATLNGDLQKRYIGSYITDQFGQLLDPITGTGFSGIDEQKRFLKFVSSSQVFTSADNEQTILEVPEFIALKNTKIQFSSHVVFSSDQAGDEIEIRNNMLLNASDRSVSQTAAIANKRFTAANTISKIYNSFAKDHTKLNINFSNTNGNVTIDSGPTTIATRMELLITSPLL
>NZ_AP019860.1|WP_151968601.1|3861716_3862955_+|hypothetical-protein
MSIFIDSSTIVNESEGEQLQNTTTDRMRVSNIVTQFDAQFRYNKQDLLWGESGNNGGGTSIHLPNESSVQMSTGDGNDGSHARRRTNIWFRYQLGIINVIEQAFVFAAGKENLKQQVGIYDDDNGILLQLDNTIAKLILKSSTIGNITIEQQNWNGDKLNGTGESGISIDWTKAQLMRIELQWRGVGAIKIYFQIEDRYILAHTIHNVNMRDSVYMTTANLPLTYEIFNDGAVAGASSMKQLSSTIYSEGGTDANNLKGDLRAGDSGDDFIPTTNTEKAILAIRPKLTFNGITNRGQIWPYDIKFHVADNEECRFIIYIGAQVPDGDWNSVGDDSIAEFNNNMTSFTPGLPLVQEFVLENRSEFSQIAEEFLRSPLVLNEDGTTQTILLITSKNLTGGTASSRCSIKWKEQK
>NZ_AP019860.1|WP_151968600.1|3860359_3861712_+|hypothetical-protein
MYGLQEDTTNVPLMQIEDEEEKFQELQNAIDSCDGYTDAEWEIKKFHPETNGWRRVARIPITESNSTEDLKEKIKMQKWGGAGTYSITLYNNDQTVARASKIKFYIDDIDKEATNTLVDHYKIPTANNQKQDAFQKELHEIQVENLRSMRYQKMKHNLKKEMNEDEPQQPQGGDQLSTMMQMQFNMQQLMLQQQQRQDEIKREDDKRREEQRLRDEQSRQEREARQEEIRLKMIELQMNQQQQNQQMLLQLMHRENPIEKLLLEKTLQDKKDPIMDSIPQFLSMVTGTQQKMQEAGFEILKKNLEKNNILTESEESIRKIAAIREEIIGPAIQALQAWKSSAQQTQYTTTTTKPETRPQVQTQTQTPTQQPEMTSAEKAVREAGTMIMNGKTGEEVWNFILRKLSNEELHELFTSEHTKQQINEALSSLANAGYSAANFILKQAQQNFSE
>NZ_AP019860.1|WP_151968599.1|3859793_3860252_+|hypothetical-protein
MKINTIKKTAIIKKEYTPAHCWICNEEIVLQRCHEKQYFAKFHCKKCFSRGFIHASKYKEYITTTYDKGEVKIDSYEAQNFGEIQIAALTECPICLGMSLRVKKCTRKLKQKGKRGRPRRVVGNAYFCNCKECRFTSFVNKGLGRYIYYHNY
>NZ_AP019860.1|WP_173013313.1|3858197_3859541_-|transglutaminase-family-protein
MDLDIIRLARGICSEWHANSKNAREKADAIHDWIAENIHYQFDPVTTELYQDSKTTLKEGFGDCDDFVILGMALNAAVGNYSRAVLIAADNEVQIDHVYYEVEVGENEWRAYDATVNGAEAGWKPKPEVVRHYVYLDGSVGTGFFGKIFKELSRFFRKFEKNVIRRPIKEIKRFAEKNFKDIYQPISRLARKIRDERRRLFEKIAKGLDDLTEDLGPFGGIAQTVIKAAAAIVVSQVAGALARSLFMQGNSGINAIASGASRVAVSPMIVENATFSALTIPEGSPLEMSAEEWGVLLSIAMTILSAGAAAVGNVALVAVTQIAQTAKTAIDVQNAIDEKEKLLDELKQIKAQVLAQAQAQQEVILKLEKDIEILRKFQQLHEEYELKIKQFRDENNQEIKNFTAEMEIASQKRIELHKADIEQRKLQIQLLAQKVARDAENSASVAV
>NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein
MNIGELINLGLTKKKMSQKELANLVGVNPPAVTKWISGKNSPPADKLIKIISLLNLTEEFFPERKQELEKLDKETNQINARLEKLESLFEQDAHENNKKKIQALEAENAMLRAAIGDFDRQELIESMHLLRSFDYDALREASNLIEEFGSAILKKAAKNLTRKKVKQA
>NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein
MNLGNTIRNRRKQLKISQKELARLMECGSSLVCKWESGKIIPNFEQIQKLEVLLSMGVLSEEFCHRRAIL
>NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein
MATELLEYSISDLQRSGLNQETIQRMRVYSLARKKTDWLKENLGFAKYDGQNLAQVTSEIMVIPYQQDFVRVKLFPQLQGAKYLSPKKGGCWLYYLDGEEKKFHKAKKPIILTEGEKKCAKLTQEIGDDFLCLGSAGISTWNTRDWQSITLKGREVYIAFDRPNERNPDEEKQLLSLFLFLWKRGAIVYFLHWPEEYEKVDDWLTAVSSPQMALKTALDESKCNDNCFTEIAAVNHLYLAQKLEAFKYDKNDITILWDRFKVRKHTAIGKGMIKAMVEKCRVDAIREESPEWIEVSERGKQSVIPGLLAKTVLAEYGDGLIFHQSTFWTYDKSSGIWVEEPENGRRIKAFIQHKLGDKLCRKSIVEDVYFQIQNYAVQQQLGFDFDKNKQFLNLQNGVLDLTSMEMREHDKDLYFTSKVNTNYVPEADCPKWKTFLWETELDEATLMRLQEWFGYCLIPDTRIEKALYLMGPGGNGKTVIVETLQALLKEYSCSLDLSEIFGRFNTAKLRNKMVNICSDNKTTIPIDDRVKNLISGGRLHGEFKGRDGFYFDNYARLVFAANDFIPTKDRSHGFYRRFDIIEIAKTWSEEERNENLKYEIWEEELPGVLNWALEGLQRLQDNNFKMTKSQAMNNTMKEFREYSNPLLQFVNDCCEIQEGNDVLCMDLYEQYALWCSSSGHKCYSASKMGKELKKIAPKIVKKKLSIKNENGFRPNYYTGIKLIARKWTEQNTQEIYNYIYCGQT
>NZ_AP019860.1|WP_151968612.1|3884834_3885035_+|hypothetical-protein
MAIKCKPPAHIQKQIKCPRKLVAKLYRKGIDLGYSLQELDYIMSAKHGLFTWLDGEELWRFFHENE
>NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein
MVGVLQVEELLKQKIQDLEKRLRKIEAGKSAPNADCLTKKEAMEWLGCSKETLNRYIDSGQLPILWPNAKKCLHPEDVKAYMRGMRPNRRRRK
>NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase
MESNFARGTDFNKDITIEYIVEHYLEKAKYTMKERSYLVEKQCVEKVIEYFHLKGLIYFRLLTPKSLQDFIVWRKETITPRGKPPSNVTVNKNIAAIKRALNLASKNQLIPQDPFANVSLIRVDKEDSPRIFSKEDIRIIEQMAEKSTIKSEIFFLVRTGLRVSEMVNLEIADVDLGKNIIIVRSVKAKSRKTRYVPIVKGLGIKLQELLNEAKANQRSLVFVNSQGNKHCLRNILRRFRTILKNAKKYGVDIEGVNIHSLRKTYISHMIMSGQDPVKVMKIVGHQSWETMKKYLFLTEEYLQDVPSLF
>NZ_AP019860.1|WP_151968615.1|3886714_3887428_-|hypothetical-protein
MMQSTPIIIVLIFCFTIPLAAQNQSFERESTNIIEQIVKQNNQNQSLEDKELLERYRNNIGGTSSIQIEKSWRFDKYLRDRTQKSQNESNRRVSTEKTSTKRINEIAKDKEKKKNKQDKLKSKHRKHRFKMNTHINSQEEIKRGYVNEKGFCYAPRPNYGRVVRIDGHSEKKYTVTKRTKEECFTVGTIFYSKTTCDITDLKTGKKTRTVKTCKGVHLSTGTPLYGATRTSVYCEKE
>NZ_AP019860.1|WP_151968616.1|3887488_3888238_-|hypothetical-protein
MKVTFILIMVAFISSTQCQEIFDDIKGLENPYVRESFAAENDFIGYEVDKCLERTKLAYKNFPLPSLEKTVTIDIVKKYKIENEDGEKSVEKTSTTEKKVVRQVLTMSIGSYSQLNLKITVSDKTTFDNCLVIYDLTSQGTPKILSTYRSKDNIFRSLDQKFRKENRDREKKTFSYKNNEAFPKVIGLVLISRRAKNYLDMGKYEWKPVPLDSNHLMILGEGVIGFDDYVYKGYRSVIVQYYYQQVVNN
>NZ_AP019860.1|WP_151968617.1|3888524_3889415_+|hypothetical-protein
MENSLNNAESEFPLKAVDYEDIREIDGQDTRQSITIRNYNLVSETAKIYRWKINELVNYSLEIYFAFLDIDLENKSVTESQSFMRLKEYAKSYYIEEKEAIRYAIDIFSGLYTNNSLVKIQSHQLVKGNKRTVQGIISELLSEYLKDDTNIKNRKDNSKKISIKTKRVEISRFAKNKSSERKSITIKNHNVIRTVAEFYRWTINELVNYSLEIFLSLLDINIKKEQVIESVSFSRLKEFAQVHGMQEGQTIRYAINIFSRLYHDGIFKKIQSSSLEEKSIKKAIPLLVTDSLKNFF
>NZ_AP019860.1|WP_173013316.1|3890157_3890910_-|PEP-CTERM-sorting-domain-containing-protein
MRKIYLILISIVLSSVIAAAPITTDGLIAFYDADDNTANDQSGNSGPNGTLNGVSISPNGAFNQGFSFDGNSSIDLGNNSIIGSDTSFSIVAWVNANSFSPQSAIYGEFNTNNADTRNYLLLDSSGRVLFDQFPNTGGALVSQNSIAIGQFSQIVYTQDGTTRRIYIDGVLEAEDTSIETYQGSIPDVARIGFRDNQNFGFDGVLDEIAFYDRALTIEQVTSQFAAVPEPSTYIAFLFGIFAIGYLRKRK

Crispr_ID: NZ_AP019860_17

• CRISPR_ID: NZ_AP019860_17
• CRISPR_location: 3891016-3891093
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_17

Consensus_repeat	Method
AAATGTGCGGATTTCGCACATTT	CRISPRCasFinder

spacers of NZ_AP019860_17

>17.1|3891039|32|NZ_AP019860|CRISPRCasFinder
CTTAAATAATTAGCAAATAATGCCTTAAGCAT

CRISPR arrays and Neighbor proteins around NZ_AP019860_17

CRISPR arrays

The CRISPR arrays of NZ_AP019860_17

>merge|NZ_AP019860|17|3891016-3891093|CRISPRCasFinder
AAATGTGCGGATTTCGCACATTTCTTAAATAATTAGCAAATAATGCCTTAAGCATAAATGTGCGGAATTCGCACATTT

>NZ_AP019860|17|13|3891016-3891093|CRISPRCasFinder
AAATGTGCGGATTTCGCACATTT	CTTAAATAATTAGCAAATAATGCCTTAAGCAT
AAATGTGCGGAATTCGCACATTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151968627.1|3896352_3896679_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968617.1|3888524_3889415_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968625.1|3895155_3895923_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968626.1|3895933_3896350_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968620.1|3892589_3893024_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_AP019860.1|WP_151968619.1|3892266_3892593_-|hypothetical-protein	unknown	unknown	gnl|CDD|200128
NZ_AP019860.1|WP_151968615.1|3886714_3887428_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968616.1|3887488_3888238_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968621.1|3893020_3893239_-|hypothetical-protein	unknown	unknown	gnl|CDD|235550
NZ_AP019860.1|WP_151968612.1|3884834_3885035_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271175
NZ_AP019860.1|WP_151968623.1|3893914_3894460_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968618.1|3891227_3892289_-|tyrosine-type-recombinase/integrase	unknown	unknown	gnl|CDD|271175
NZ_AP019860.1|WP_173013317.1|3894437_3895154_+|DUF2075-domain-containing-protein	unknown	unknown	gnl|CDD|238541
NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151968622.1|3893247_3893763_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein	unknown	unknown	gnl|CDD|273716
NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_AP019860.1|WP_173013316.1|3890157_3890910_-|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|379155

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	5.08088e-09
NZ_AP019860.1|WP_173013317.1|3894437_3895154_+|DUF2075-domain-containing-protein	gnl|CDD|238541	cd01121, Sms, Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of branched DNA molecules.	7.29854e-14
NZ_AP019860.1|WP_151968618.1|3891227_3892289_-|tyrosine-type-recombinase/integrase	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	5.33932e-24
NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	1.22312e-05
NZ_AP019860.1|WP_151968621.1|3893020_3893239_-|hypothetical-protein	gnl|CDD|235550	PRK05660, PRK05660, radical SAM family heme chaperone HemW.	0.000232005
NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein	gnl|CDD|273716	TIGR01613, putative_primase, phage/plasmid primase, P4 family, C-terminal domain. This model represents a clade within a larger family of proteins from viruses of bacteria and animals. Members of this family are found in phage and plasmids of bacteria and archaea only. The model describes a domain of about 300 residues, found generally toward the protein C-terminus. [DNA metabolism, DNA replication, recombination, and repair, Mobile and extrachromosomal element functions, Prophage functions].	1.24869e-59
NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	9.88034e-09
NZ_AP019860.1|WP_151968619.1|3892266_3892593_-|hypothetical-protein	gnl|CDD|200128	TIGR01764, Probable_excisionase, DNA binding domain, excisionase family. An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General].	0.00121018
NZ_AP019860.1|WP_173013316.1|3890157_3890910_-|PEP-CTERM-sorting-domain-containing-protein	gnl|CDD|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	1.3496e-18
NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase	gnl|CDD|271175	cd00397, DNA_BRE_C, DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	1.32916e-27

Protein sequences

>NZ_AP019860.1|WP_173013316.1|3890157_3890910_-|PEP-CTERM-sorting-domain-containing-protein
MRKIYLILISIVLSSVIAAAPITTDGLIAFYDADDNTANDQSGNSGPNGTLNGVSISPNGAFNQGFSFDGNSSIDLGNNSIIGSDTSFSIVAWVNANSFSPQSAIYGEFNTNNADTRNYLLLDSSGRVLFDQFPNTGGALVSQNSIAIGQFSQIVYTQDGTTRRIYIDGVLEAEDTSIETYQGSIPDVARIGFRDNQNFGFDGVLDEIAFYDRALTIEQVTSQFAAVPEPSTYIAFLFGIFAIGYLRKRK
>NZ_AP019860.1|WP_151968617.1|3888524_3889415_+|hypothetical-protein
MENSLNNAESEFPLKAVDYEDIREIDGQDTRQSITIRNYNLVSETAKIYRWKINELVNYSLEIYFAFLDIDLENKSVTESQSFMRLKEYAKSYYIEEKEAIRYAIDIFSGLYTNNSLVKIQSHQLVKGNKRTVQGIISELLSEYLKDDTNIKNRKDNSKKISIKTKRVEISRFAKNKSSERKSITIKNHNVIRTVAEFYRWTINELVNYSLEIFLSLLDINIKKEQVIESVSFSRLKEFAQVHGMQEGQTIRYAINIFSRLYHDGIFKKIQSSSLEEKSIKKAIPLLVTDSLKNFF
>NZ_AP019860.1|WP_151968616.1|3887488_3888238_-|hypothetical-protein
MKVTFILIMVAFISSTQCQEIFDDIKGLENPYVRESFAAENDFIGYEVDKCLERTKLAYKNFPLPSLEKTVTIDIVKKYKIENEDGEKSVEKTSTTEKKVVRQVLTMSIGSYSQLNLKITVSDKTTFDNCLVIYDLTSQGTPKILSTYRSKDNIFRSLDQKFRKENRDREKKTFSYKNNEAFPKVIGLVLISRRAKNYLDMGKYEWKPVPLDSNHLMILGEGVIGFDDYVYKGYRSVIVQYYYQQVVNN
>NZ_AP019860.1|WP_151968615.1|3886714_3887428_-|hypothetical-protein
MMQSTPIIIVLIFCFTIPLAAQNQSFERESTNIIEQIVKQNNQNQSLEDKELLERYRNNIGGTSSIQIEKSWRFDKYLRDRTQKSQNESNRRVSTEKTSTKRINEIAKDKEKKKNKQDKLKSKHRKHRFKMNTHINSQEEIKRGYVNEKGFCYAPRPNYGRVVRIDGHSEKKYTVTKRTKEECFTVGTIFYSKTTCDITDLKTGKKTRTVKTCKGVHLSTGTPLYGATRTSVYCEKE
>NZ_AP019860.1|WP_151968614.1|3885610_3886540_+|tyrosine-type-recombinase/integrase
MESNFARGTDFNKDITIEYIVEHYLEKAKYTMKERSYLVEKQCVEKVIEYFHLKGLIYFRLLTPKSLQDFIVWRKETITPRGKPPSNVTVNKNIAAIKRALNLASKNQLIPQDPFANVSLIRVDKEDSPRIFSKEDIRIIEQMAEKSTIKSEIFFLVRTGLRVSEMVNLEIADVDLGKNIIIVRSVKAKSRKTRYVPIVKGLGIKLQELLNEAKANQRSLVFVNSQGNKHCLRNILRRFRTILKNAKKYGVDIEGVNIHSLRKTYISHMIMSGQDPVKVMKIVGHQSWETMKKYLFLTEEYLQDVPSLF
>NZ_AP019860.1|WP_151968613.1|3885200_3885482_+|helix-turn-helix-domain-containing-protein
MVGVLQVEELLKQKIQDLEKRLRKIEAGKSAPNADCLTKKEAMEWLGCSKETLNRYIDSGQLPILWPNAKKCLHPEDVKAYMRGMRPNRRRRK
>NZ_AP019860.1|WP_151968612.1|3884834_3885035_+|hypothetical-protein
MAIKCKPPAHIQKQIKCPRKLVAKLYRKGIDLGYSLQELDYIMSAKHGLFTWLDGEELWRFFHENE
>NZ_AP019860.1|WP_151968611.1|3882600_3884835_+|DUF3854-domain-containing-protein
MATELLEYSISDLQRSGLNQETIQRMRVYSLARKKTDWLKENLGFAKYDGQNLAQVTSEIMVIPYQQDFVRVKLFPQLQGAKYLSPKKGGCWLYYLDGEEKKFHKAKKPIILTEGEKKCAKLTQEIGDDFLCLGSAGISTWNTRDWQSITLKGREVYIAFDRPNERNPDEEKQLLSLFLFLWKRGAIVYFLHWPEEYEKVDDWLTAVSSPQMALKTALDESKCNDNCFTEIAAVNHLYLAQKLEAFKYDKNDITILWDRFKVRKHTAIGKGMIKAMVEKCRVDAIREESPEWIEVSERGKQSVIPGLLAKTVLAEYGDGLIFHQSTFWTYDKSSGIWVEEPENGRRIKAFIQHKLGDKLCRKSIVEDVYFQIQNYAVQQQLGFDFDKNKQFLNLQNGVLDLTSMEMREHDKDLYFTSKVNTNYVPEADCPKWKTFLWETELDEATLMRLQEWFGYCLIPDTRIEKALYLMGPGGNGKTVIVETLQALLKEYSCSLDLSEIFGRFNTAKLRNKMVNICSDNKTTIPIDDRVKNLISGGRLHGEFKGRDGFYFDNYARLVFAANDFIPTKDRSHGFYRRFDIIEIAKTWSEEERNENLKYEIWEEELPGVLNWALEGLQRLQDNNFKMTKSQAMNNTMKEFREYSNPLLQFVNDCCEIQEGNDVLCMDLYEQYALWCSSSGHKCYSASKMGKELKKIAPKIVKKKLSIKNENGFRPNYYTGIKLIARKWTEQNTQEIYNYIYCGQT
>NZ_AP019860.1|WP_151968610.1|3882307_3882520_+|helix-turn-helix-domain-containing-protein
MNLGNTIRNRRKQLKISQKELARLMECGSSLVCKWESGKIIPNFEQIQKLEVLLSMGVLSEEFCHRRAIL
>NZ_AP019860.1|WP_151968609.1|3881644_3882151_-|helix-turn-helix-domain-containing-protein
MNIGELINLGLTKKKMSQKELANLVGVNPPAVTKWISGKNSPPADKLIKIISLLNLTEEFFPERKQELEKLDKETNQINARLEKLESLFEQDAHENNKKKIQALEAENAMLRAAIGDFDRQELIESMHLLRSFDYDALREASNLIEEFGSAILKKAAKNLTRKKVKQA
>NZ_AP019860.1|WP_151968618.1|3891227_3892289_-|tyrosine-type-recombinase/integrase
MVHYRKDRKCWVACWQDSKENRRKKSGFDSKKNAEIYEARQKILTENNLARGVDYDIDITVEEIVARYLEKAKYSMKTRSFEVEKQCIEKVLEYFSEESLTLCRYLKSSHLQGFIMWRKETITPRGSPPSDITINKNIASIKRVFKYGKDYNLIPNNPFKSFKAIRVDKEDAPRILTKEDVKIIEELAIDSVVKNELFFLVRTGMRASEMINLEVGDCDIEKKKIIVRSYKAKSRRTRFVPMTKSILELMKTLVVRANDEKRKLVFVNSKGRKHNLRNVLRRFQTILRKAEGKGVNIDGVSIHTLRKTYISHMIMSGEDPAKVMKIVGHESWSTMKKYLYLTENYLNDIPEIF
>NZ_AP019860.1|WP_151968619.1|3892266_3892593_-|hypothetical-protein
MSIKEKVAFLLKRDKQNEKRIKDLEKENKKKDKLISKLMAKNSAPNKNYLTKDQAAAWIGCSRRKIDDMIIGGNIHVEYPGSKACINKHEIIPLMKGLKKQHGSLPKG
>NZ_AP019860.1|WP_151968620.1|3892589_3893024_-|hypothetical-protein
MTLEELHHRLGKFDGYAISMFDILCHRTENLEDCICNAISVIEEDGDLYSMEIWSVEKLTVKGVAPCGETIIDHMWDRFQFEEFMEDVSAKQKALLGEMIAETISNWIKKENINFDYYTGIKKETVSYTELQSMARETERKETA
>NZ_AP019860.1|WP_151968621.1|3893020_3893239_-|hypothetical-protein
MEDFEIVVPLEFMAREDNVQSLVLGQEVIMKSIDDFVKKGYAVKENDRYLLTEKGVRFMNRLFARLEMKETI
>NZ_AP019860.1|WP_151968622.1|3893247_3893763_-|hypothetical-protein
MQKDVPEENNELPEKWNDVLEDAWKNHKNGYDREKFYRLYSDSFWTPEDEENYQMEVASQTIDTKSGDYTIPVLANVPIADPQPTYADKKEEFEKQYPILTTQEVENWIRKSLPGFAMKTQKLIAKHFGGSEQEFCEYFSRHLIPAYKYRGSFSPKIAMIKIRDKEEFCFV
>NZ_AP019860.1|WP_151968623.1|3893914_3894460_+|hypothetical-protein
MIKTNQNVTFRVEEGIEVNSKTYVKTTDLLINANTVKEIDHVLFGSYAKVSIINASGSQATVVTNIHYRNSDLLHQKKHSLTKLDIHTTLIVNGGNHTSPWIDVSEYESLSGMVKTDQNGTFRIDYSDDASTVLASDTSGYTANTTPGFTAEKIGRYAQFVFENDSGADQTEFNYVLYGRI
>NZ_AP019860.1|WP_173013317.1|3894437_3895154_+|DUF2075-domain-containing-protein
MSCTVVSNSKYLCVSCQNISEEKSRRCKKCNAIFSIVKIPASVQVSLPKPKTASEIMKRKAIGKPLKGFEFIGSLPKKFSMVIHGEPGSGKSYFALQIADAIANNSKRKTYYVTSEEELENLDFQNKIEYCEPSENLIFESVKNKKEFLKLIRNNSANIIVDSISDLGITAKEIKEFREEIGTFIYILHVTKDGDYRGTTQLIHDPQVQIVVAKGIAKTKKNRFGMSGQEYEIFTKED
>NZ_AP019860.1|WP_151968625.1|3895155_3895923_+|hypothetical-protein
MDFIDNLKESGITQVSWGGSGFASSYLAHSKAKQIMNSLEENTWLGYVMPGATKKVVAVGAAVVATGATSIAASIISPENRKYVWIGGFLSLILILTQEVVGIGSGGSIGNSSEGVNNGSGEGQSTIPTEQEVIDAIHNLPNQQTMQELKKTGFIDAIIENNNTLIVTVGDDVIYSPIGSAYIVDSSTMEIFLNEALFLIANAQQVENVEIRRNFGNQDNINSTIDRILDQAQKYNKITILRDKPVISWGTVNAS
>NZ_AP019860.1|WP_151968626.1|3895933_3896350_+|hypothetical-protein
MSDIQNISTEKMSFIETIKHDLKNTSYRIYVMFLVCITLSVFLTACVSGVGPSKRFVNTSYENSQELFPVAISLIENANADILKKAVRKEDQQAIEQATKNGLEIYKMGLIRKFKNWRFDIKKQHEILQSHDKKIKKE
>NZ_AP019860.1|WP_151968627.1|3896352_3896679_+|hypothetical-protein
MPDINESSRENIFEDLKKEFINEAGQEVWNEINEIGTDTLKDLAKAKFYSLVGTEADKKLAGAAVAMITDSLKDLIGAATDQAVNYALERLENFVSKIVFREIIKLIV

Crispr_ID: NZ_AP019860_18

• CRISPR_ID: NZ_AP019860_18
• CRISPR_location: 3986186-3986486
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_AP019860_18

Consensus_repeat	Method
AAGAGATTGGGCAACTTTCTTCTCT	CRISPRCasFinder

spacers of NZ_AP019860_18

>18.1|3986211|44|NZ_AP019860|CRISPRCasFinder
TACTCACTTACGTTTAAAGTCGACAAAAATAACACGTCTTCCAC
>18.2|3986280|44|NZ_AP019860|CRISPRCasFinder
TACTCAGCTAGATATATGGGATTCAAAAATGACAAGTCTCCCAA
>18.3|3986349|44|NZ_AP019860|CRISPRCasFinder
ATCCACATTAAATTTAATCAATACAAAAATAACAAAGTTACCAA
>18.4|3986418|44|NZ_AP019860|CRISPRCasFinder
TACTTTTCTTGATCTGAGTGATACACCAATAACAAAACTTCCAC

CRISPR arrays and Neighbor proteins around NZ_AP019860_18

CRISPR arrays

The CRISPR arrays of NZ_AP019860_18

>merge|NZ_AP019860|18|3986186-3986486|CRISPRCasFinder
AAGAGATCGCACAACTTTCCTCTCTTACTCACTTACGTTTAAAGTCGACAAAAATAACACGTCTTCCACAAGAGATTGGGCAACTTTCTTCTCTTACTCAGCTAGATATATGGGATTCAAAAATGACAAGTCTCCCAAAAGAGATCGGGCAACTTTCTTCTCTATCCACATTAAATTTAATCAATACAAAAATAACAAAGTTACCAAAAGAAATCAGCCAGCTTTCGTCCCTTACTTTTCTTGATCTGAGTGATACACCAATAACAAAACTTCCACAAGAAATTGGGCAACTTTCGGCCCT

>NZ_AP019860|18|14|3986186-3986486|CRISPRCasFinder
AAGAGATCGCACAACTTTCCTCTCT	TACTCACTTACGTTTAAAGTCGACAAAAATAACACGTCTTCCAC
AAGAGATTGGGCAACTTTCTTCTCT	TACTCAGCTAGATATATGGGATTCAAAAATGACAAGTCTCCCAA
AAGAGATCGGGCAACTTTCTTCTCT	ATCCACATTAAATTTAATCAATACAAAAATAACAAAGTTACCAA
AAGAAATCAGCCAGCTTTCGTCCCT	TACTTTTCTTGATCTGAGTGATACACCAATAACAAAACTTCCAC
AAGAAATTGGGCAACTTTCGGCCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151968700.1|3989983_3991120_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968702.1|3992325_3993195_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968697.1|3987738_3988269_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968705.1|3998945_3999473_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968690.1|3978636_3978858_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968698.1|3988352_3989303_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968703.1|3993585_3994461_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968687.1|3975191_3976337_-|hypothetical-protein	unknown	unknown	gnl|CDD|379062
NZ_AP019860.1|WP_151968694.1|3982982_3983726_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968689.1|3977478_3977817_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968688.1|3976930_3977488_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013324.1|3987293_3987461_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968695.1|3984176_3985931_+|Na+:solute-symporter	unknown	unknown	gnl|CDD|271371
NZ_AP019860.1|WP_151968704.1|3994471_3997234_+|hypothetical-protein	unknown	unknown	gnl|CDD|227608
NZ_AP019860.1|WP_151968699.1|3989280_3989994_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968693.1|3982202_3982826_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224991
NZ_AP019860.1|WP_151968701.1|3991116_3991920_+|tail-fiber-protein	unknown	unknown	gnl|CDD|377845
NZ_AP019860.1|WP_151968691.1|3978868_3979861_-|FAD-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224238
NZ_AP019860.1|WP_151968692.1|3979875_3982200_-|molybdopterin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224446
NZ_AP019860.1|WP_173013322.1|3973931_3974987_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|275380

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151968704.1|3994471_3997234_+|hypothetical-protein	gnl|CDD|227608	COG5283, COG5283, Phage-related tail protein [Function unknown].	0.00575475
NZ_AP019860.1|WP_151968695.1|3984176_3985931_+|Na+:solute-symporter	gnl|CDD|271371	cd11477, SLC5sbd_u1, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	7.94087e-170
NZ_AP019860.1|WP_151968693.1|3982202_3982826_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein	gnl|CDD|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	6.04637e-67
NZ_AP019860.1|WP_151968701.1|3991116_3991920_+|tail-fiber-protein	gnl|CDD|377845	pfam07484, Collar, Phage Tail Collar Domain. This region is occasionally found in conjunction with pfam03335. Most of the family appear to be phage tail proteins; however some appear to be involved in other processes. For instance a member from Rhizobium leguminosarum may be involved in plant-microbe interactions. A related protein MrpB is involved in the pathogenicity of Microcystis aeruginosa. The finding of this family in a structural component of the phage tail fibre baseplate suggests that its function is structural rather than enzymatic. Structural studies show this region consists of a helix and a loop and three beta-strands. This alignment does not catch the third strand as it is separated from the rest of the structure by around 100 residues. This strand is conserved in homologs but the intervening sequence is not. Much of the function of phage T4 appears to reside in this intervening region. In the tertiary structure of the phage baseplate this domain forms part of the 'collar'. The domain may bind SO4, however the residues accredited with this vary between the PDB file and the Swiss-Prot entry. The long unconserved region maybe due to domain swapping in and out of a loop or reflective of rapid evolution.	1.1705e-10
NZ_AP019860.1|WP_151968691.1|3978868_3979861_-|FAD-binding-domain-containing-protein	gnl|CDD|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	8.05653e-57
NZ_AP019860.1|WP_151968687.1|3975191_3976337_-|hypothetical-protein	gnl|CDD|379062	pfam13191, AAA_16, AAA ATPase domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	0.00451426
NZ_AP019860.1|WP_151968692.1|3979875_3982200_-|molybdopterin-dependent-oxidoreductase	gnl|CDD|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	6.98437e-175
NZ_AP019860.1|WP_173013322.1|3973931_3974987_-|STAS-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	1.6367e-21

Protein sequences

>NZ_AP019860.1|WP_151968695.1|3984176_3985931_+|Na+:solute-symporter
MILETIDWLCIAVFFIISLFIGLITSRKAGSSAKEFFLSGRNMPWWLLGVSMVATTFSADTPNLVTDIVRQNGVSGNWTWWAFLLTGMLTVFVYARLWRRLGVMTDLEFYELRYSGKAAAFLRGFRAVYLGIFFNVVIMATVCLAAIKIGGIVLNLSPIASLTIALSVTVLYSSLGGLRGILLTDFFQFIIAMIGSIWATVVILDLPQVGGLTNLLQSPEIQGKLDFFPDFSNMELLIPLFILPLAVQWWSVWYPGSEPGGGGYVAQRMLAAKSENHALTATLFFNVAHYALRPWPWIIIALCSIKVFPDLISIQKAFPHLDPGIVKHDTAYPAMITLLPSGLMGLMVASLIAAFMSTISTHLNWGASYVVNDFYLRFINSNASEKQLVSIGRITTVILMIASGCIALFLSNALQAFQILLQIGAGTGLLFILRWFWWRINAYSEITAMIVSFIVALYFSLFSSGLSPHVELCIGVAITTISWILVTFLTPATDEKVLMSFYQLVQPGGAGWKPIADKVKKQDKIGSIPTAILCMVLGCFSTYSALFATGYWLYGNYFMASLLTTATIISSALLWLCWSRESQK
>NZ_AP019860.1|WP_151968694.1|3982982_3983726_-|hypothetical-protein
MKTYFKLHASLLKYCKERYAVLQQNKDSTKNSIQSNFLGLMMEEIKNLECDYDRFSDAIEVIKLAAEMINLEQNSEDIVAQERDRFVKTLLSYSSDTLDTLSQDFCQRLSKNESQIIRKKAQEAWRAGFGYYFPLEPHPNPKFNLKAFFSTDFEKKFSNESLHAMMKSWNVECVYELNEGGDDYIVATDNWEPLDSSPETFWFCDECDWILYVSHENSTTVGGKLAEWVLSQWKDAENHIWRIPEFG
>NZ_AP019860.1|WP_151968693.1|3982202_3982826_-|2Fe-2S-iron-sulfur-cluster-binding-domain-containing-protein
MEEKKNLSQKEISRRSFLKGAGIASVGAVIATTASVDIKADTKNDSDVIGKNGISCEFDVNGKKYAQKVPPRTTLAELLREDLNLTGTKVVCDRGACGACTVIVDGKSVCSCMTLAIDSAGKKIETIEGLANGDELHPLQEAFVNHDALQCGFCTPGMVMSCKNLLDHNAQPTLPEVRKAVSGNLCRCGTYPHVFKAVMDVSGKKGE
>NZ_AP019860.1|WP_151968692.1|3979875_3982200_-|molybdopterin-dependent-oxidoreductase
MAKEVKLHIGVENDLEEIKVTIPDDSPKPWDGKDKLKFVGGKTPRLDGKEKVTGNAKYTFDMKLSGTLHAKFFRLPCPSAVVTKIDTSAAEKAPGVKGIVLVQETLPLTVRYADQELLAIAAETAHQVDEALKLVKVEYEKRPFVVDLAGAQKSDAPEVFQGKFERDKEVGQIEVDEDNAGQRRGNVRAPQDYTKGGTKEEIEQFIEKSEFSVSATYQTQVQTHSALETHGVVANWEGDHLTVWASTQGTFSVLGELAQVLKIPQTNVRVITDYMGGGFGAKFGAGPFGIAAAKLAKKTGRPVKLMFSRREEHVSGGNRPSSMQTLKIATNKSGKLEALSLVSRGSAGISTGAGTSAPAKGIYECPKIYTQDADVFTNAGPSKAFRAPGHPQGIFALEQSIDDLAYKIGMDPLEFRKINTMNHDVRQKEYQIGAEKFAWHKRNPKVNADKGPIKTGMGMANSVWYYFYGVGYQATIKVNGDGSVELLNGTQDIGTGSRTAMAVVAAEELGLKPHDIVVRIGDTKLGFGPPSGGSQTTAGITPAVRDAAYLAKNKMLEIAATHLNATAQELDIRDGVIFVTSDPTRKLSWKKVASKIPGGTFSVMGERKKDHIDIKGAPAVHFLGRNFYTIGGMQFAEVEVDTETGVIKVKRILAIHDCGRPINRLTLQSQLNGGIIQGVSYALFEQRVIDRNHGLQVNPNLEQYKIAGSMDIPEIETIVLDTNRGNSSTGAQGIGEPATAPVAAAIANAVYHAIGVRIRDLPMTPAKVLEALHS
>NZ_AP019860.1|WP_151968691.1|3978868_3979861_-|FAD-binding-domain-containing-protein
MNSFEYAMPKRTADVFRALESSDSIIKAGGIDVLDLIKEGIAHPQRLVNINSIDELKYIEGNQTTGVKIGPGTTLAELASSEVLSGSYRALAQAAGSTATPQIRNSATLGGSLCQRPRCWYFRNKDYHCTRKGGFTCFAVNGENENHAIFENDFGCVMVHPSTTAVALIALGAKLTIASAKSSREILVEDFFVTPRENMHRENILEQGEIITAIHLPPAAKNMVSYYYKQKAKQSFDWPIAEVAVSMQLDGKKCQNPRVALGAAAPVPMRSKEAESALNNQEVTIDIAASVGKEAMKKATPLSQNKYKVHIFQAVIKRTVCWASDIDPFA
>NZ_AP019860.1|WP_151968690.1|3978636_3978858_-|hypothetical-protein
MEKKDIVVSNCCHLRCKMAYLPIPGETDWRTNQSSLSNYWCLRTMTPVGPDDYYVAPEVCQNRRKCYESEELT
>NZ_AP019860.1|WP_151968689.1|3977478_3977817_-|hypothetical-protein
MIPVPGMEKLLELANEIKITPLWDSQEKINIELDLPEIKTIDISACKSYSEIPIDWFDRFPTLEKVILPFGLNLVATLREFPPEERIKFKAFYEKSKGYALCRNTQKEDTCE
>NZ_AP019860.1|WP_151968688.1|3976930_3977488_-|hypothetical-protein
MRIVKQKTLHAVEPRTEYRGCTFYLEGPHCLDDCVFDNCSFRGEMHYVESEESQRYPEFRNCNFNCKEVSMKSIGVDELIAEVETIDIEKIITKLIVVPFSETQDKLKIERDLLKIKTIDLSAYESYNEIPVEWFERFPTLERVILPLSTDLVICFQEIPLKKRIKFNISRVNNGYKLTRLKKID
>NZ_AP019860.1|WP_151968687.1|3975191_3976337_-|hypothetical-protein
MNPYITGFPVAPQVFVGRNRQQMYFQRAVKQTRLSNPVSPQNIAIMGNWGIGKTSLLNKCLQDAQEENILVVKVTLSPEKCKTMEDFAVNTVDALYQSIWHYDFSTKVKSQLSKWKIDGFKLLGVEIKKTKNKSPTPATILTNKIKELWDIIKNDVSLMIIAYDDLHYLSKCYANGLYDLRAIFQDTREAGVRAMLVVTGDKSLFSNIRGISEPLVRFFEQIHLGTFSELEAKECLKRPLAVNNINLKFEKKVMEEIFQKTEQHPYFITFFAHDLFEYKSAGRITIKLFQKVYPEILEHLAATRFINDIAITNDTERKLLDYFCRTETLRTKDVKGVTNPSMAFKRLEEKNLIKKVKRGYYQLYHTLFREYLTISSLDESF
>NZ_AP019860.1|WP_173013322.1|3973931_3974987_-|STAS-domain-containing-protein
MLYYQTEDLELPDLPKIRHVKVIGEMKSYNHDFTLDEYLENTLSQDINHIIVDISGVTIMNSGAIACLFGFDDKFSIFGGKMVLIQVPEKVSSLFDMLGIPFKMHNTLEDAVRNILNKNDASLTRKKTIKSKSLETIENSTSYHGCTFFLKEDDTYQIAHCTFENCSFRTDIVLDEIKDCFFENCNFSNRFCLNLAYAKRLPLGLGMLSSLTHLNLQSAEITKLPWEIRRLSSLTHLDLECSEITKLPPEILGLSSLTQLNLRGAKIRELPNEIGQLSSLTHLYLSGTCIDVLPKEIGQLSSLKVLDLGGTRITELPKEIGQISSLRTIDLSGTNITELPKEITKTIDVVV
>NZ_AP019860.1|WP_173013324.1|3987293_3987461_+|hypothetical-protein
MNLFSKALIRNIAIVVTLKMDGKFKMIVKSKSLTTIESSNSYHGWCDSSLGKYIA
>NZ_AP019860.1|WP_151968697.1|3987738_3988269_-|hypothetical-protein
MRAILRTISIILLASQITALPLTVNVHKDEGNSTLDGGRHAWSQIKISENGKVEIYELVINKVLLAGYCFKSAYIFVDEKGNTLARYKESQICVDGKWTPLPHKRTRVIFHDLPVEIAKKVRGVKVNWSPGSKDPLKLLEENIKKLINISEASLPSSEALEKIKGIAKLYLLFKKA
>NZ_AP019860.1|WP_151968698.1|3988352_3989303_+|hypothetical-protein
MSQKQSRIQAEIELEELQELEAKIKIISDKLEKVDRNFNLKRNLYLYLFRKKRNDSYQVVRFDIESNGGIPKKLKIVACHDRKDEFSRFSEALNIYAKRGGTKKPQLIFASDSSLKGLYERIYFKNLKENASISQCSVVLDKKVCDVDKIISIIGRNTYHFVTWVEFDSKDNKIQLDIFPEKIKEKMRIPCVVEYLYYEKFGACKDRKETYLLGNNTPNVIQYASDIDNVLGIKQQPASDAFGDELHLCPELDTIIQELKRQLHLLARDDSCEEVVKYLEVLDEYKDVTTTRKELLRSLKIIFSYEPKNYDYPDKN
>NZ_AP019860.1|WP_151968699.1|3989280_3989994_+|hypothetical-protein
MTILIKTKCSKLPEYLSLFIFQDFGVTKNYPTEVLLQKRFHIASCPICFDQAKTFIKQTRNFCPFLFEIPRYVYSVSKTPFLLTKKYQELEVEKMKPCKINSLQKHIKKCHCCSYWERIVENGWMPNLTVKKKFVVSLFPCDLFSAAGTTDLLGNIHVGVLEKKGFPQGTCIISTLKRDGYSIRVESPVPITLVMEFYKGSQMLEKVSISNEIPDKIVPCERIIGWTKLELYEVYDG
>NZ_AP019860.1|WP_151968700.1|3989983_3991120_+|hypothetical-protein
MMANCRIGYPYASSDRKIKKDSIVILKASDYRGFTTVTSNKFSYQIPTTDEGPNVLVGFKKGVVGKLIESKDERQSIAKNGEIRGEGKSSQLAIVLACCAVYEGSTDRLPIILFSAAIDIPAGAKPFIGATINSYCTEAYVKDSLIHKYEAACMVGAVALVLCMRDAKILTQLVGKEITEIDLLSSLLCRNTKEPAIVGVGKKSLPDLASKIGINKYHYTEYSKEKSKYQYRKLLIFLAVCFVCLAYFIRAKSSEKYQRNQIEKLCLEIEGENRKVKDLWKEINRLWQVLGENPSGELNPKEAIEKLKKAVNKIVADLEALWAEVEGENYDIQNIRSGIEDLFKILGEPIPNNLNIRELIIELTAIVGEPINFEGSGK
>NZ_AP019860.1|WP_151968701.1|3991116_3991920_+|tail-fiber-protein
MKIILSIVLLFFFSINVHSDDEKRLTHKERITVLESKVKKQEVQIKTLIESIQKLANIVEQQKSNSSLKFELKIIPVGVVTAFAGEADTLPSNWMLCDGSWLDCKEFDKLYEVLGKAHGYQAIAKKEFFALPDYQGYFLRGVSHNSKVDPDADRRKEAKKGGNKGNKVGSIQGDQPGPHLHTINDLGHEHGVNDPGHEHLHGPLEEWRKDIGNGSKITRFTGRNNYTSRTKTSISIVKSKSNISIRSNKTKETRPTNAYVNWIIKVK
>NZ_AP019860.1|WP_151968702.1|3992325_3993195_-|hypothetical-protein
MKYIFLFFILSTTVFSDSGEDFIRFKMKLKSFTTKKTNADDDKVLGLFYSYKNAHDPYFIVYRSKERDGKTIKQSCRITSYLTNKVGDTEKVDEIICEENLTFGDEVRVVIHAYDADGSQDVSPGTLTGDDAKKYATEKSAAKPLILYTIAATSAHAINYFSNTEITKIANDLLYNLVIKYMEDNALEVTAETIKLALTKVISGTTITVAISAITVVAGAYTYNISDDDYLGSTEIIINANYNFKRLQRLQKTNANTFKFTEEKRKIIKNNLSEIEIEIEEETSFFIEK
>NZ_AP019860.1|WP_151968703.1|3993585_3994461_+|hypothetical-protein
MKYLIIPMLLLFFIGPISGQENKKLDFNDMEYLLKILSIEDICEQVKKRGHKIINTLQNRERLANLGFGEKLHIFWPSDTSIQQQNLKKQLQQLGKEIKILQEKADNIDVVSINDIDKDIRSLNQQVTAIQSSVDSLYTRLGITKSDNNEKQIGAIGDIKYSLLPLDEFQKQNGSGWVLLAGQEIEKTPLALVLGIKKLPDARGVFLRGRNYNRSKNEGNPKGDLLVGTYQKDDFKSHGHKTTNANSHNGHGRPATGGDGSEGVGYHTSCNSGGRETRPRCITVNIYVKVY
>NZ_AP019860.1|WP_151968704.1|3994471_3997234_+|hypothetical-protein
MFRVSCILITFMLNVLPQENNVSIHNGNMYIQKLAIRSSKEFQNIHINLSSSEYKKALSNIIKTQKRYRTSEKFLKVAIRADQFLINTISGYSSLAFTGGITGELSQQLDDMYNQVVDLNEAQIATLLKDATTRMTDEAWKKIANSLKQDEYAQAKVLKEILNNFYSDNIPEKQLAVSNQAISRFATRVALTNTFQNEKIKRQLIKEIEFLRSEQKKLDEKVVKKNKEVVDKITMAFIHRQNMENSIAKIADQTTRLSLNIDKIHIETKKSINANSEKIEKNNRRINLFEKSLKRHKTSILQNKKFIVSIGERVSFSEKQIAKLTNAQSFTEELLYGNLNDESKLTALKNREFLKNKLQGRKRHLEILRLQAKIERDKSIREVENITNSLNKAYQIAVNLGFKGKSQKKVAKILKYTNAASQAYIAYQKGDYLGTVLSVSSLFGKKSKSPKEKRFEAIMQAISGLNYKLDQVLKNQQTIIINQQKISELVIKTHRLVMTNLVTLSSEIALIQDHVIAIQRIALQEAKDRAAGCHLFLNSREGYKFWNFKNGRFVSYLDMQKHYVADNSNRINCWSGIKALEKILIKDRQNVVYDPIFYMASHSANNLEFMKYVNGAYLPALKYFESTMRLGKHDSNFKLAINYLLAPSKKREQSDQWIYAASQKNDWFSGKESELIKEEVLQHLLYPPVIEQYCHYVLQMVPYLELTSEDNSLYLRTPSNLLALSAEDEMTRQVRSRRAQRLLEKMLEIVRSSLVQQNLLSGHCIMPFLEKDFQDVIHNVQIDKQRKKALFKLLNSNNFIRENLLRRLVYKHLYQNEISQHLYWQGWMTGSKQHFQKLFPNKWNLELKNDIWFLVVDKQFLPLPEPKTVSEEIFQVTDYIDVLEELQKHLEIAISEYGIFSQNHNGENERFVLLHMLQGK
>NZ_AP019860.1|WP_151968705.1|3998945_3999473_+|hypothetical-protein
MTVLLQSQVQKLRAANINTFLLIASFVTFFTPILLYFQKEVPRQHKSTVLLIGFSIAVVVIAVTIVYWKKSQIGAKVVRQDADIILEIEGISPITIHQYKYGQINVGKIRELIVGIYDQQGALVLRFKVMYGKMHSVPSHWTPNDIPAGKPTHEYSAKGKFLIELIDTLQNHPSA

Crispr_ID: NZ_AP019860_19

• CRISPR_ID: NZ_AP019860_19
• CRISPR_location: 4050914-4051354
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of NZ_AP019860_19

Consensus_repeat	Method
AGTTGACCGATTTCTTTTGGTAACTGT	CRISPRCasFinder

spacers of NZ_AP019860_19

>19.1|4050941|42|NZ_AP019860|CRISPRCasFinder
GTCAGTTTGTTTGTATGCAGAATGAATTCGCTAAGATTTTTG
>19.2|4051010|42|NZ_AP019860|CRISPRCasFinder
GTGAGTTGATTGTTACCTAGCCAAAGATGAGTAAGACTTTTG
>19.3|4051079|42|NZ_AP019860|CRISPRCasFinder
GTTAGGTTATTGGAAGACAAACCAAGGCAAGTAAGGTTTTTG
>19.4|4051148|42|NZ_AP019860|CRISPRCasFinder
GCGAGGTCATTGGAAGACAAATCGAGATAAGCAAGATTTTGG
>19.5|4051217|42|NZ_AP019860|CRISPRCasFinder
GTCAATCGATTATCGTACAAATCAAGTGTAGTAAGATTTTGA
>19.6|4051286|42|NZ_AP019860|CRISPRCasFinder
ATTAACCGATTACGGTGCAAATCGAGTGTGGTGAGATTTTGG

CRISPR arrays and Neighbor proteins around NZ_AP019860_19

CRISPR arrays

The CRISPR arrays of NZ_AP019860_19

>merge|NZ_AP019860|19|4050914-4051354|CRISPRCasFinder
AGCTTTCCTATTTCTCTTGGTATCTTCGTCAGTTTGTTTGTATGCAGAATGAATTCGCTAAGATTTTTGAGTTGCCCTATTTTTTCTGGTATTTCGGTGAGTTGATTGTTACCTAGCCAAAGATGAGTAAGACTTTTGAGCTGCCCGATCCCTTCTGGTAAACCTGTTAGGTTATTGGAAGACAAACCAAGGCAAGTAAGGTTTTTGAGCTGTGTTACCTCTTTTGGTAACTCTGCGAGGTCATTGGAAGACAAATCGAGATAAGCAAGATTTTGGAGTTGACCGATTTCTTTTGGTAACTGTGTCAATCGATTATCGTACAAATCAAGTGTAGTAAGATTTTGAAGTTGACCGATTTCTTTTGGTAACTGTATTAACCGATTACGGTGCAAATCGAGTGTGGTGAGATTTTGGAGTTGACCGATTTCTTCTGGTAACTGT

>NZ_AP019860|19|15|4050914-4051354|CRISPRCasFinder
AGCTTTCCTATTTCTCTTGGTATCTTC	GTCAGTTTGTTTGTATGCAGAATGAATTCGCTAAGATTTTTG
AGTTGCCCTATTTTTTCTGGTATTTCG	GTGAGTTGATTGTTACCTAGCCAAAGATGAGTAAGACTTTTG
AGCTGCCCGATCCCTTCTGGTAAACCT	GTTAGGTTATTGGAAGACAAACCAAGGCAAGTAAGGTTTTTG
AGCTGTGTTACCTCTTTTGGTAACTCT	GCGAGGTCATTGGAAGACAAATCGAGATAAGCAAGATTTTGG
AGTTGACCGATTTCTTTTGGTAACTGT	GTCAATCGATTATCGTACAAATCAAGTGTAGTAAGATTTTGA
AGTTGACCGATTTCTTTTGGTAACTGT	ATTAACCGATTACGGTGCAAATCGAGTGTGGTGAGATTTTGG
AGTTGACCGATTTCTTCTGGTAACTGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151968748.1|4055527_4056742_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151968751.1|4062892_4063930_+|substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|380646
NZ_AP019860.1|WP_151968747.1|4054473_4055298_-|DNA/RNA-non-specific-endonuclease	unknown	unknown	gnl|CDD|224777
NZ_AP019860.1|WP_151968741.1|4049868_4050561_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968749.1|4056770_4061699_+|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl|CDD|237108
NZ_AP019860.1|WP_151968734.1|4040173_4042636_+|hypothetical-protein	unknown	unknown	gnl|CDD|276809
NZ_AP019860.1|WP_173013327.1|4044412_4046422_-|hypothetical-protein	unknown	unknown	gnl|CDD|199211
NZ_AP019860.1|WP_173013328.1|4047601_4048534_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_AP019860.1|WP_151968746.1|4053605_4054427_-|hypothetical-protein	unknown	unknown	gnl|CDD|130141
NZ_AP019860.1|WP_151968743.1|4051715_4051997_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968745.1|4053046_4053490_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013329.1|4048539_4048956_+|EamA-family-transporter	unknown	unknown	unknown
NZ_AP019860.1|WP_152022010.1|4049129_4049804_+|glutathione-S-transferase-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|198298
NZ_AP019860.1|WP_151968752.1|4063935_4065447_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|184134
NZ_AP019860.1|WP_151968737.1|4046661_4047030_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968750.1|4061904_4062684_-|TIGR01458-family-HAD-type-hydrolase	unknown	unknown	gnl|CDD|319812
NZ_AP019860.1|WP_151968744.1|4052029_4052938_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968735.1|4042641_4044087_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968733.1|4039371_4040004_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151968738.1|4047078_4047429_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151968748.1|4055527_4056742_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.70768e-94
NZ_AP019860.1|WP_151968751.1|4062892_4063930_+|substrate-binding-domain-containing-protein	gnl|CDD|380646	cd19991, PBP1_ABC_xylose_binding, D-xylose binding periplasmic protein. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	3.60416e-134
NZ_AP019860.1|WP_151968747.1|4054473_4055298_-|DNA/RNA-non-specific-endonuclease	gnl|CDD|224777	COG1864, NUC1, DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism].	4.11987e-55
NZ_AP019860.1|WP_151968750.1|4061904_4062684_-|TIGR01458-family-HAD-type-hydrolase	gnl|CDD|319812	cd07509, HAD_PPase, inorganic pyrophosphatase similar to a human phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP). LHPP hydrolyzes nitrogen-phosphorus bonds in phospholysine, phosphohistidine and imidodiphosphate as well as oxygen-phosphorus bonds in inorganic pyrophosphate in vitro. This family also includes human haloacid dehalogenase like hydrolase domain containing 2 protine (HDHD2) a phosphatase which may be involved in polygenic hypertension. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.9086e-91
NZ_AP019860.1|WP_151968749.1|4056770_4061699_+|amino-acid-adenylation-domain-containing-protein	gnl|CDD|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
NZ_AP019860.1|WP_151968734.1|4040173_4042636_+|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.24874e-09
NZ_AP019860.1|WP_173013327.1|4044412_4046422_-|hypothetical-protein	gnl|CDD|199211	cd10913, Peptidase_C25_N_gingipain, gingipain subgroup of the Peptidase C25 family N-terminal domain. Gingipain, produced by Porphyromonas gingivalis, exemplifies the Peptidase family C25, a unique class of cysteine proteases. P. gingivalis is one of the primary gram-negative pathogens that causes periodontitis, a disease also associated with other diseases such as diabetes and cardiovascular disease. The gingipain subgroup contains extracellular Arg- and Lys-specific proteinases called Arg-gingipain (Rgp) and Lys-gingipain (Kgp); RgpA and RgpB are homologous Arg-specific gingipains encoded by two closely related genes, rgpA and rgpB, while Lys-specific gingipain is encoded by the single kgp gene. Mutant studies have shown that, among the large quantities of proteolytic enzymes produced by P. gingivalis, these three proteases are major virulence factors of this bacterium. All three genes encode an N-terminal pre-pro fragment, followed by the protease domain; however, rgpA and kgp also encode additional C-terminal HA (hemaglutinin/adhesion) subunits which consist of several sequence-related adhesion domains. Although unique, their cysteine protease active site residues (His and Cys) forming the catalytic dyad, are well-conserved, cleaving the C-terminal peptide bond with Arg or Lys residues. Gingipains are evolutionarily related to other highly specific proteases including caspases, clostripain, legumains, and separase. Gingipains function by dysregulating host defense and inflammatory responses, and degrading host proteins, e.g. tissue, cells, matrix, plasma and immunological proteins. It has been suggested that they enhance gingival crevicular fluid (GCF) production through activation of the kallikrein/kinin pathways, thus increasing vascular permeability and causing gingival inflammation, a distinctive feature of periodontitis. RgpA and RgpB are also able to cleave and activate coagulation factors IX and X in order to activate prothrombin to produce thrombin, which in turn increases production of GCF. The gingipains also play a pivotal role in the survival of P. gingivalis in the host by attacking the host defense system through cleavage of several immunological molecules, while at the same time evading the host-immune response by dysregulating the cytokine network.	1.17023e-62
NZ_AP019860.1|WP_173013328.1|4047601_4048534_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.80822e-17
NZ_AP019860.1|WP_151968752.1|4063935_4065447_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|184134	PRK13549, PRK13549, xylose transporter ATP-binding subunit; Provisional.	0
NZ_AP019860.1|WP_151968746.1|4053605_4054427_-|hypothetical-protein	gnl|CDD|130141	TIGR01069, Endonuclease_MutS2, MutS2 family protein. Function of MutS2 is unknown. It should not be considered a DNA mismatch repair protein. It is likely a DNA mismatch binding protein of unknown cellular function. [DNA metabolism, Other].	0.0043196
NZ_AP019860.1|WP_152022010.1|4049129_4049804_+|glutathione-S-transferase-N-terminal-domain-containing-protein	gnl|CDD|198298	cd03189, GST_C_GTT1_like, C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain. GTT1, a homodimer, exhibits GST activity with standard substrates and associates with the endoplasmic reticulum. Its expression is induced after diauxic shift and remains high throughout the stationary phase. S. pombe GST-III is implicated in the detoxification of various metals.	1.17335e-47

Protein sequences

>NZ_AP019860.1|WP_151968741.1|4049868_4050561_-|hypothetical-protein
MFSRFTFVLLLLLSMSYVSAATISIRATGEVDKVVKTAGLFDLSSVDVGDVVTFEWLLDSADFVGSVTGPGQDITNFLSSANFRIFDNSGDIINVDFVDFFGSRNINGFGSRGILDDQGNPLEGAVLAFINHNDDNTLRLENRVGVTGNTSEFGFGPAEFDNQSFEDMAEFIHNNIPFASFAAVDGGNIDLIQMFSDDGTTVTVTAAIPEPQTYCLLVFFGLIFFSKRKK
>NZ_AP019860.1|WP_152022010.1|4049129_4049804_+|glutathione-S-transferase-N-terminal-domain-containing-protein
MITVHHLESSRSQKILWLLEELQLEYKIEHYKRNKVTNLAPPELKKIHPLGKSPVVTDGENVIAETGAIIEYFVDKYTDKNLKPAAGTPEYMRYTYWLHTAEGSIMPLLVMKLIFGVISTKSPFFVRPIAKAISGQVNNSYIMPGLNNMFAYIEAELNRSSWLAGDQFSAADIIMSNPVEGAIAQGVVSPNQHPKIYDFLTRIQQREGYQKSVEKGGTFIPTNS
>NZ_AP019860.1|WP_173013329.1|4048539_4048956_+|EamA-family-transporter
MHWIHFAVIAMISHSALMIILKEVTNSGLQTEIINFYFLLFTTIVIFCFAATRNVRFQIPGKFVVWFMVLAIIAFFYNYFAMKAISAAPNPGYVVGILSCNIIIITIVGSLLFGNPLPTTKIVGIALMVCGSLLITMV
>NZ_AP019860.1|WP_173013328.1|4047601_4048534_+|GNAT-family-N-acetyltransferase
MTATKMHNEFVSSVRQSSRGMVRELGLLAGRHQKLEVTYSEGHTLLEVEKHKMLTIGDLAKILQLDKSTMSRVVYELIQKGCLEYSQNPNDRRQKLVHLTPQGQKQVDAINNVANSHVQRALDLLTAKEQKLVEQGLALYAKALANCRQEQEFTVREITKEDNAAMASIVRRVLAEFEFSGPGTAADDTELEDMFATYNKPKTAYFIAVKDNRVIGGGGFAPLKGSKSDICELQKMYLLPEARGLGLGEKLLRQSLEKAKEMGYKKCYLETAFAMNKARNLYKKLGFTELKKSMGDTGHYRCECWYIKEL
>NZ_AP019860.1|WP_151968738.1|4047078_4047429_-|hypothetical-protein
MRSKKNSRKIVVDDIEYRWRAKGGPGSISVGIWPANDIGPYMMAIFGYDETFVRRPDGYITSNGDQIVITNKIVKRVIDCARQKYGYDPNTKGKQLCLSGDEVEWRDAVRSSSNYL
>NZ_AP019860.1|WP_151968737.1|4046661_4047030_+|hypothetical-protein
MKESKLDRINKIYKNLCDVFIEKEGTTIFTQTKDILKPLLYDLAKITFYASVVQSKEQVQNLHTITKLYEESLQDAHFMVTDQIKNDALTRLNKLIHDMALNIGLTILLPLSKQKVMIKSVT
>NZ_AP019860.1|WP_173013327.1|4044412_4046422_-|hypothetical-protein
MKKMMCLMLILIGIGMHAEWQAIDPQAQVDQEIQVKVLRFSAQEMQIEISIPGYHDEQVLAGETVCSNISIPGASVLMKKGYPTIPKLGKLLCVPDNCKVSMRVVSKVEVEKNITQRIIPSKGHLTRDINPKDVDFEFNEVYGQDSYWPTTQFSLGQCFQFRDISGVRLRVLPVRFNHVQNKMKILQKVVVAFEFKAKDSAKLRFKPISPSKVYDNLYRNTFLGYGNLPKQQIRESRKLLVVTPVEYTKTIQPWIEWKQKAGYEVTTHTTSNRDRSFEIKDDIQRLFDKSATRFDYVVLMGDAKYSAYFEDCQPMPTFEGSKEGAAADRVYVRLRGFDNYPDACISRISGDTPQDIAVQLEKIMQYEQNPAKGKWLKNGICVASDEGHFKDWQRAEWLQKGGSKSQNVPIENGGLLANGFDSFTDVYDPGANPAKITEALNRGSSIICYIGHGTPISWVSSGFNNDDIHQLSNSGLYPVIWSVACVNGKFVHLDECFAEAWLRKKDGGAVAVEAASTNESWIPPCDKQSATINSIINNSALTFGAQELAGCIRAMEIWGDDDDSEGNKMAEQCNLFGDCTLIPRYGKQSELQVHVDYQAGKAVFRVQSNERKVKNAIVTVYTSDFGYRVSHTTNDRGEVSVAAEKLLRGKLFYTVVAPNAIPIVDRLLR
>NZ_AP019860.1|WP_151968735.1|4042641_4044087_-|hypothetical-protein
MNKSLILFVLIAFSTLYSEHSLFFSADNGIDQSRIVQFDLNSKTSNILVEKPVIGLDFSIDPANRRVYWIEKDPANPIEVIKRKDFTKNNEEVIYALPAGAELIHIDEVVVDGFNNQLFFSICNILDKEASLVQLDLATKKSNILVKKSGLDLDLDLDFAIDTINKRAYWIENKSEESVIKRKDFDGSNEEVVYSKSTGGEIISMDEVKVDGKNNQLFFSMNFDVNDARVMQLDMKAKSVKIIVQKQMDDMDFAIDFTNKKVLWIERDLANELSVVKRSNFDKSEEEIVYASTNKQSFFIDEIVTVNYDPKMVFDAGVLGKDQEYSLHMNFPQPQQSVNVKIEWEGNAVLGLPVSMKAQFQDNQLQFTRDNVETLMVNFRHLSFSKETARNIRITISGFQNVPKSILFQPLFGDPDNSPAKLTQRIAIDTNRIVEATYNFPAKSNVEVQASATKGLWILELHDTSVKPLPTKGYVDILISK
>NZ_AP019860.1|WP_151968734.1|4040173_4042636_+|hypothetical-protein
MHYKAKYLHIYMKDFVRCVNKNRSILGLHGDNFSVEEAKEILLMYASCGHKQIWKVEPQLLHLLENQHRHIRLFAMDLLKVLARSSHTTTASQKRCHMKQIANSLLQNEKICSLNNKEVSAIVKQHMQTQANEGEKEQAFSFCHPKPQEYFKANDKDLFPILQILAKQHKPEFAKQQTIEQKPTSYPKIEKALKNQHYDLAIMLLNKQILINNPEDVKAQRLLIGTINRKYKEEGYPGKLRNTTQKAILLIQIRLARITKNWREVISLANDYLTYNPQNIRILHILGNAFVKSDYLPSAIFIFELILTLDPRNIRALLALTKIHKDMKEYDKAIFYCQKAVKLKPSDDEIAKEVKRIAAIKTTDVYTESKYSRDLIKDKDEANRLERLGQISQKKDAAPVRKPQPKQKLKPQLQLQTPEPIEKAVKRKKKKISTKEPIVPASQITVSEEETVKIVSRKRQAPEEFRKQEIIAKIPKVDREELPAFEKFLSEDAGRPGPMERIIAQSVNLMKFLQYTLGLKCIVIVNAVDLTVDAISSYITGIFRTWKMSKSIHRNLQRNVNNSHAAELTLELQKNRARLSRLFMLHGYDPHLYNEQLRPSFAVKLIIESRGHLDEMKQDLAFLTTKQTTQTIRNSFKDTIMSFIPNPFSIFTTWKDLAILSLWMKYNRRQIEQMYADFIVCYCQTIRILNQEQQNSSASVLLKYEENLLKRLGFTLEEQGDIEYWIERCRVALQRITQMLINPGKFIDCSYWPKADLLSEIKKGNQNPQYVLQLEWWLNKQVGKHLSKQTTTKELYLRLEEAYSLRRRYKLQKKLSQKFI
>NZ_AP019860.1|WP_151968733.1|4039371_4040004_-|hypothetical-protein
MNNLTRRLFLNSAQICGFFIAMMFISIFMKNDTFSVGGFACAISFNILLIIAYKSYDSYVLDFNKKQFYTRRKFFSWVFSTCIAHFDDIVGVSVDGELHSANRVEWWEYFTIIILKNGKTYRISDYQASFFSEDVDDEKFFRESEEVAKQLAEILQVKFYPGKRQHFLIVTSKHGQLEITHKAAKRRLMYLYLIGLALIMMVIIGKLLIK
>NZ_AP019860.1|WP_151968743.1|4051715_4051997_-|hypothetical-protein
MSSIKTKTLYTFLLFISFFAVCCCSFLGAKYKSHYDVAHYIKSQEIRYLGVQISLRNIVIFSYEWEDKKRYSINYYHWHFIPWGKIIHESTPD
>NZ_AP019860.1|WP_151968744.1|4052029_4052938_+|hypothetical-protein
MAILHQQICPDLKIVFTIPNEIISLGDLIATKTTAQIYSDMDAIFIEDSTSQVLVNDNKIFIHQLKEGDVIRVDDMQLVFSENKIVFPPLYYNKWHCVREVWSKSDSVSVGGRGAGGEIALDSLFLSCVFENERDFPDKCLYEGLLHESIVVASYSLLVLLYRNSKLLKNTQWKNLHTGKVRYYYGCVVSSYTWNEFVQLGKQKIIPGLDAYRGYLQRCSIPEHSKMLQRFLKDWQYKNTDMWRNSERNYVVLLEDDCDHASPKYGKYGNSFEGMRYSAELFLTLRNVFGNNIDMNPFFMKI
>NZ_AP019860.1|WP_151968745.1|4053046_4053490_+|hypothetical-protein
MNPVFACILFVFFVVIALVGLAKKRTREILSKFTDKEILQKASNAYFFGTPEILCKFTDKKTLEKAYDGNFYGRGNGVLVLLKDELYFEMWSPQIKLRIPIDYITKIKIKPYLWFELLEVMFNDGTDSAVWRIKKPKKWQESLQKLI
>NZ_AP019860.1|WP_151968746.1|4053605_4054427_-|hypothetical-protein
MHKNLCILIILSFTTLIFANVTAGKWKKEWKNILEEYAEAIGKTKKKDFEKSLKDKKVNNECDEIEDLLKALDKKFKNKDKNPKIYKRDIFGDHERLGATYSKMHMKTAKYVNKMSKLFKKKKRKKELEALSELGKKFNKIKKSINKSFDKKPPSLKRQKLEELVDERDDALKKVSKLKKKLEDAEDPDLNKIIRKVSGYIENVREKLDELRGLYDDEGPGGLTLMYSQLGSSKAALDDEDKNRLLQQMTNLESYFSRFMQSYFNDLERQIRE
>NZ_AP019860.1|WP_151968747.1|4054473_4055298_-|DNA/RNA-non-specific-endonuclease
MGYNEKFIEAFKIHLPRLKDNALQDSLSKGKAFDYTHFSIVMNRVRKLAIYTAHNIDGDNLVSVPRTGKWRHDERVGEYQTGNEAYSRNPWDRGHLVRRTAVAWGEDAHKASSDTFHYTNAAPQHENFNQDEWLELENWVLDKAKQSQRRMCVFTGPIFSDRDQEYRAIQIPSAFWKVIVLTKPSGELSTVAFLMKQDELWQDKKGKDFLDLTLYQVAVGVIEELTDLDFIFDQDAEITAQSENYLRQFDPLAAFVKSEDKSWPVIKTANDIVV
>NZ_AP019860.1|WP_151968748.1|4055527_4056742_+|protein-kinase
MQTDNTNTQYFDKYKIISEIGRGRMGIVYKAFDSKLRRVVALKIMNNAETKSIQRFMLESTALSTLDHPNIVKFYEFGHNPRPHIAMEYLEGITLENYIQTRNISGTSLLDIMEKICLALQHAHQKNILHRDIKPCNIILTGDEVKVMDLGLAKLTDNQVNLVRSSEFEGAIHYMSPEQIQGTTNRTSDIYALGATFYECLTYRPVFQGNSNVSILAQIAKKDPIPPRELNPDISPYMEAICLKCLAKKPQKRYRSFGELAQEFKNFKMQRAIIAKQYTSFDRINRTVAQNKVISILLTTVFCISIVFSAVIFSTLVETERQKNAAILAKNNAEKREKQLQQFNTAILQSLNYLSQSKHKNVFLDKKFTGPISKIFARFQKAHEKKELREHTQPMIRQLQKYIK
>NZ_AP019860.1|WP_151968749.1|4056770_4061699_+|amino-acid-adenylation-domain-containing-protein
MSSQNTVYNLVQNITPQQRHFHCILNQESKSIVYGELLQHIEEKVTLFREWGIKRNERIAIVLPNGPEMASAFLTVACAATSAPLNPKYTEKEYKFYLTDLNAKAVIVPHGEASPVRIVADKLSIPILELQSNIEKPGMFDLTKPSQLPTQSVTDVDFCQEQDIALVLHTSGTTSRPKIVPLSHSNICNSAKSICRTLQLQSHDCCLNIMPLFHIHGLMGVLLSSIVARASICCTTGFAMQDFFSWVKINNPTWYSAVPTMHQAILMESSASKDIIKNSRLRLIRSSSSSLPPVVLKNLEKTFSVPVIEAYGMTEASHQMTSNPLPPSKRKPGSVGIATNIEVDIMDEQGNILPTGSVGEIVIKGNSVTNGYENNPQANSEAFVDSWFRTGDLGYLDQDRYLFINGRVKEIINRGGEKISPHEVDEVLLEFPHICQAVTFAVPHKRLGEDVAAAVIVEKGFTVGEQQLRNFAFTKLAEFKVPSQIIFVDKIPLGPTGKMQRIGLADKLENELKRPCVLPSAPLEKEIAKIWSEVLDVDNLSIHDNFFICGGDSLMGARVVNRINKQLQLQLPIEILFRYPTIQQQYQFICEDTKKHNFSQSIPRVSRSEITPLSFVQERVWYLHNIAPEGITHNRPCNLLLLGKLNINILQESLQKLLQRHETLRMLIAMDSVGRPVQKILENTTMSLYMVDLSSFDQQQQQQEIQNHLHNEVTTPFAIEKETMVRGKLLKVNAEKYLLLMTFHHMIFDGWSQYIFIRDLANIYQATSGGESVDLNPLPIQYTDFAAWSRKQDFRSRIAYWKEHLANLPILELPKDKMRPKSQSYQGKKIPLSFTKTTYQNLKAQSRKHEVTLFTTVLSVFYTLLYKYSQQQDIVVGVPFAGRDTVEVENLIGMFMNPLPMRICLSDDITFADLLKKVHTTYLQAHSNQMPLQLISKELGVKRSANYESLFQTLFIFENFPTLPKKMDNIDILPEKDPSEFSFLDISFEFVDNQNELQGFFFYATDLFHDATAQKFVDHFCHLIDEIITNPQQRISQLQMVSDEERAQLIAISTGPQREIYPRCFHELFTEQAKKTPNQTAAIFCNQRITYHQLDCRANQLAHYLHAQQPAKLIAILMDRNLDFLVTILAIFKMGAAYLPLSPKHPQKRHQQIIDSSGVSHIITCDQYSALAKKLCVNKIYNISSIDFEKLPTQQLNISTELQDLAYVIYTSGSTGLPKGAMVNHKGMVNHIYAKIEDLELTAQDIIAQTASQCFDISVWQFLANLLVGGCVQIFPDDVVYDPQTLVHEINDNQISIWETVPSLMKLILNVLKNDPMPFARLRWLIPTGEVLSPHLAKEWLQSYPQIPLVNAYGPTECSDDVTHYVIDTPPTTDAHNMPIGKPIRNITTYVLDKNLHILPVGIPGELHVGGVGVGDGYLNDEQRTKKVFIKNPFSQTSTKLYKTGDIAKYLPDGNIQFLGRLDNQVKLRGLRIELGEIEVALERYPQIQQAAVVYNEQLLIAYIVTHREYAEKNLRIFLEETLPQYMIPQHFVCLESMPLNANGKIDRKQLHLPQNLAVLPYQEPRNKEEQIIAEVFADVCHCEKVSVHDDFFDLGGHSLLIFKLRKKILQKTNKQIPIAAVFEHKTVESLAKFLKSIPYRQ
>NZ_AP019860.1|WP_151968750.1|4061904_4062684_-|TIGR01458-family-HAD-type-hydrolase
MAFDNIKGFLFDIDGVLSIGNDLIPGALATIEKLKAQQIPYRFVTNTSTKSLDTLHKKLQKQGFPIAKNEVFHSPLAAVLHMREQQQRTCYLFVEEEAKKDFAEFTISEKPEVIVVGFMEKGWDLALLNKAFRMVMAGAEFIALHKNKYFQVQDGLQLDSGALVVGLEYVTGKEATVVGKPSASFFELALQSLGLPPHEVAMIGDDIEADIGGAQNCGLKGILVKTGKYREELVRTSWVKPDLVIESVGCLFDYVLMSS
>NZ_AP019860.1|WP_151968751.1|4062892_4063930_+|substrate-binding-domain-containing-protein
MSIRTLLMTVSFILSVLIGLVVSQSGAKATSKSDDKIVIGLSLDTLKEARWQKDRDIFVACAKELGADVLVQAANSDDTTQMQNIEALISRNVDVLVIVPHNGKAMAKAVEKAHDAGIPVIAYDRMITDCDVDVYISFDNVKVGEMQAKFLLKTLSNHGKIIRVYGSKTDNNAFLFKQGQDNVLKPFIEKNMIEVIHEDWAEDWKPENGKKIVNAAISLHGDNFAAVLAANDGTAGGAIQALTEEGLAGKVKVIGQDAELVACQRIIQGTQTMTIYKPLKKLALRAARLAVDMAKRKVIIAKESIPNGKIDVPTIAIDVQVVTKENMEDTIVKDGFHNRKDVYGE
>NZ_AP019860.1|WP_151968752.1|4063935_4065447_+|ATP-binding-cassette-domain-containing-protein
METLNFTAKNIVKKFPGVIALGGVNFELRAGEIHSICGENGAGKSTLIKVLSGIHAHGSYEGNLYLGDKPLILSSLKDAEQAGITVIYQELALIEDMTVAENIFLGREPTHNGIIDWHRIYNEAQQLLNQFHIDIDPTTRLGDLGVGQQQLVEIVKALGKKSRILILDEPTSALTEKEVEVLLSIVKNLRTQGISCVYISHKLEEVFDISDRITIIRDGQSITTLEAKKTNRDEVIHYMVGREIKDLFPRKKTSPGETLLKVSDLCVHDEEDKAALHDISLEVKAGEVLGIGGLMGSGRSELLLHIFGAWGKRRSGTVEIHGEPLQNHTPTQSIQKGLVMVSEDRKMYGLILEKDIGFNLSLSSLNSFSNMFLIDSAREFVANDKYFKSLRVKAPNLESIVENLSGGNQQKVVIGKALMTDPKIVFLDEPTRGIDVGAKLEVYELMNQLTEKGYAIIMISSELPELLGMSDRIMMLCEGRVGGTFVNENINQQQLMAAAMEAK

Crispr_ID: NZ_AP019860_20

• CRISPR_ID: NZ_AP019860_20
• CRISPR_location: 4635909-4636075
• CRISPR_type: TypeV
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP019860_20

Consensus_repeat	Method
TCAAATCTAAGTGAGTAAGAGAAGAGAG	CRISPRCasFinder

spacers of NZ_AP019860_20

>20.1|4635937|41|NZ_AP019860|CRISPRCasFinder
GGATAAGACTTCTCTTGGCAATTCCTCTATTTCGGTACCAT
>20.2|4636006|41|NZ_AP019860|CRISPRCasFinder
TCGTACAATCTCTTTGGGTAACTCTTCTATGTCCGTCTCTC

CRISPR arrays and Neighbor proteins around NZ_AP019860_20

CRISPR arrays

The CRISPR arrays of NZ_AP019860_20

>merge|NZ_AP019860|20|4635909-4636075|CRISPRCasFinder
ACAAGTTTAAATGCGTAAGAGAAGAAATGGATAAGACTTCTCTTGGCAATTCCTCTATTTCGGTACCATGAAAACTTAAATGAGTAAGAGAAGTAAGTCGTACAATCTCTTTGGGTAACTCTTCTATGTCCGTCTCTCCCAAATCTAGTTCCACAAGAGAAGAAAGT

>NZ_AP019860|20|16|4635909-4636075|CRISPRCasFinder
ACAAGTTTAAATGCGTAAGAGAAGAAAT	GGATAAGACTTCTCTTGGCAATTCCTCTATTTCGGTACCAT
GAAAACTTAAATGAGTAAGAGAAGTAAG	TCGTACAATCTCTTTGGGTAACTCTTCTATGTCCGTCTCTC
CCAAATCTAGTTCCACAAGAGAAGAAAGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151969177.1|4635224_4635716_-|GFA-family-protein	unknown	unknown	gnl|CDD|226314
NZ_AP019860.1|WP_151969170.1|4626257_4627415_+|acetate/propionate-family-kinase	unknown	unknown	gnl|CDD|234680
NZ_AP019860.1|WP_151969169.1|4624218_4626261_+|phosphate-acetyltransferase	unknown	unknown	gnl|CDD|235537
NZ_AP019860.1|WP_151969180.1|4637940_4640799_+|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl|CDD|234734
NZ_AP019860.1|WP_151969171.1|4627423_4628191_+|ZIP-family-metal-transporter	unknown	unknown	gnl|CDD|223505
NZ_AP019860.1|WP_151969185.1|4650156_4650735_-|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|131644
NZ_AP019860.1|WP_151969181.1|4641105_4645593_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969174.1|4628939_4633823_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969184.1|4649856_4650069_+|MbtH-family-NRPS-accessory-protein	unknown	unknown	gnl|CDD|225790
NZ_AP019860.1|WP_151969175.1|4633884_4634466_-|hypothetical-protein	unknown	unknown	gnl|CDD|180941
NZ_AP019860.1|WP_151969172.1|4628203_4628404_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969188.1|4654766_4657871_+|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl|CDD|223911
NZ_AP019860.1|WP_151969179.1|4636976_4637930_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969173.1|4628409_4628928_-|YdcF-family-protein	unknown	unknown	gnl|CDD|99750
NZ_AP019860.1|WP_151969187.1|4653673_4654783_+|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NZ_AP019860.1|WP_151969168.1|4623321_4624101_+|hypothetical-protein	unknown	unknown	gnl|CDD|214780
NZ_AP019860.1|WP_151969183.1|4647451_4649719_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969176.1|4634784_4635192_+|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|224276
NZ_AP019860.1|WP_151969186.1|4650949_4653403_-|hypothetical-protein	unknown	unknown	gnl|CDD|238362
NZ_AP019860.1|WP_151969182.1|4646051_4647452_+|RRXRR-domain-containing-protein	unknown	unknown	gnl|CDD|379519

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151969177.1|4635224_4635716_-|GFA-family-protein	gnl|CDD|226314	COG3791, COG3791, Uncharacterized conserved protein [Function unknown].	6.24064e-10
NZ_AP019860.1|WP_151969170.1|4626257_4627415_+|acetate/propionate-family-kinase	gnl|CDD|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_AP019860.1|WP_151969169.1|4624218_4626261_+|phosphate-acetyltransferase	gnl|CDD|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_AP019860.1|WP_151969180.1|4637940_4640799_+|excinuclease-ABC-subunit-UvrA	gnl|CDD|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_AP019860.1|WP_151969171.1|4627423_4628191_+|ZIP-family-metal-transporter	gnl|CDD|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	5.45356e-37
NZ_AP019860.1|WP_151969185.1|4650156_4650735_-|PEP-CTERM-sorting-domain-containing-protein	gnl|CDD|131644	TIGR02595, conserved_hypothetical_protein, PEP-CTERM protein-sorting domain. This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures].	9.21067e-05
NZ_AP019860.1|WP_151969181.1|4641105_4645593_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.21987e-98
NZ_AP019860.1|WP_151969174.1|4628939_4633823_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.12531e-96
NZ_AP019860.1|WP_151969184.1|4649856_4650069_+|MbtH-family-NRPS-accessory-protein	gnl|CDD|225790	COG3251, COG3251, Uncharacterized protein conserved in bacteria [Function unknown].	3.63944e-24
NZ_AP019860.1|WP_151969175.1|4633884_4634466_-|hypothetical-protein	gnl|CDD|180941	PRK07352, PRK07352, F0F1 ATP synthase subunit B; Validated.	0.00198629
NZ_AP019860.1|WP_151969188.1|4654766_4657871_+|efflux-RND-transporter-permease-subunit	gnl|CDD|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_AP019860.1|WP_151969173.1|4628409_4628928_-|YdcF-family-protein	gnl|CDD|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	1.70333e-31
NZ_AP019860.1|WP_151969187.1|4653673_4654783_+|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	4.72324e-58
NZ_AP019860.1|WP_151969168.1|4623321_4624101_+|hypothetical-protein	gnl|CDD|214780	smart00702, P4Hc, Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.	8.77353e-20
NZ_AP019860.1|WP_151969183.1|4647451_4649719_+|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.69386e-98
NZ_AP019860.1|WP_151969176.1|4634784_4635192_+|pentapeptide-repeat-containing-protein	gnl|CDD|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	2.74414e-21
NZ_AP019860.1|WP_151969186.1|4650949_4653403_-|hypothetical-protein	gnl|CDD|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	4.47145e-12
NZ_AP019860.1|WP_151969182.1|4646051_4647452_+|RRXRR-domain-containing-protein	gnl|CDD|379519	pfam14239, RRXRR, RRXRR protein. This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with pfam01844.	1.0687e-84

Protein sequences

>NZ_AP019860.1|WP_151969177.1|4635224_4635716_-|GFA-family-protein
MTTHFGEEYASVNDENFKAKYRASCYCGAICYEVQDDPVDAKICHCIACQKLHGAPMQWAAIFYKRDVRITAGVENMEFYNSELHKHERILPCKVSCKKCKTLIADEGRNMWLAFPSLFDFGSPPRIPEKFRPTCHIFYGMRSMDVEDGATKWSGHKNKSQRL
>NZ_AP019860.1|WP_151969176.1|4634784_4635192_+|pentapeptide-repeat-containing-protein
MIFFRKKNSIEDENLVGANLSNQYLKNVNLSGVNLERVDLSRSNLKNSQLSGANLKNANLSYAKLEKSDLSGANLSGANLKNADLSGVDLSGANLSGANLKKVNLKGANLSDVDLTGTNLTNACLFGTNLADTDL
>NZ_AP019860.1|WP_151969175.1|4633884_4634466_-|hypothetical-protein
MYRIILLLLIATLVYPSVCYPQENIIQTEELQEIISYVKKMHHTTKSIQKDTHKNFQETITLLEKLKSSYDNLPEFVKNITEEKRSGIKEDNTQNIEKSLRIAAKDISQAAKDLNQVAKTVDKATSHIRQTAKDINNAAQTLKKIASRLSQMTNNVKKVTDETLDSVEKIHKKLHGSSRTSHCKTQETTRDNK
>NZ_AP019860.1|WP_151969174.1|4628939_4633823_-|protein-kinase
MTPQEKQFLEKALVANLIDQQQAQHAIRLQQQTEQQGKNASIAQCLQHLKYLSANQIQHLQQSTGVGEHAMTQQFPQTKEAKFGRYTIISELGRGGMGKVYKAYDPNLDRVVALKMLLTDQDQHAIDRFMREAQATAKLKHANIITLYDIGIEDSQPYFTMEFIEGDSLEQMAKKSTMSNHQIAILMATVADAVHYANKQGIIHRDLKPDNIMMKDNTPIVMDFGIAKLDKAQKKLSKTGMIVGTLQYMAPEQAAGKNRAVDQRSDVYSLGAILYRLLTGHKMFPAGSQIYILNQILNHDPVPPSKHKKIIARDLENICLKAVEKKQSDRYQSAKELSEDLRAFGAGETVKASPTTWQRKLWRKCKRYRAHIAVAIIALIVTNLYFSSLSGSVTISPRNEHGEFISPKAILINGKKIAQTQLKNHYIAPGNYNITLKFNDYQDVACENVAITAGDDNTQIIDVKPKKGEISLTSSLSEVKASFVHDKNQKETTFAVPAQEKLATGNYTVTFSKLNHFSYKHHLTVDNKKKTINSDLRPMILWRKEINYNVVSNGMTLAHLGDSLELIVSDRGGKINSYGYPNFFPKWEIPLKLDIATPRQKITTHDFNKDGIMDLIVANYAQFMVFDGKTKQQIFRWYPFWDHKFIIADANDDAYEDIVLLTRYHGIRIFYSHQGSFDSQKRFSHINTSVSGLSHPLLLNKSTVLCASANTVLHVDLQKRKVRSIYTHGSDILDIKIAKTTKQKLLLLYDSQKLISLDLDTLRTKETIHEFPTPHRINEMSMIDIDNDGNEEVLFQRDQLYCVDIHNKKIKWQLNTQNDFFEGSPVFVSDLDHDGKLEVVTWTRQQTAGQKSTNTIFVVDHQGNEQQKAVIDDEIVSMVFVDTNQDHRLEVLFLAGSAIHCLEYYPANTSPQVSTFSRNLPAMAIPPVAADLNGDKIKELIIIDELGYLHCLDGSNKQSLWKTDRSLNVMRATTADFDGNGEVEVFAVGKKNIALLSKDGEAIWKSPIVIDIVNSPIAVDVDGDHYKEIICYKRAPARVHCIDIKERKVRWQAAKKQGLQVIHGTAQAQDVNNDGTQEIFILSGYQVHCLDGPSGRVRWSQPVPNIGEGGQIVSCRVRGKTLIFAGQVAGFISCFDALSGKKHWHKNVLSGDIRTVVLHQISGRQCIAFTTANDEVFCLDAFSGEIVWQRKITPRYYLENVQQPRTYAQIIALNVDVNADGVNDLVTTCSTHTFYTLSGIDGSWLGDTNAFTKVERLPRILDLDGDHKQDMLFVDRHLQIFSMNDIEKYFSHLLHVPQQFTTLDQDSEALYLHYLDNLVKHRKYSLLQKQLPAVKNKLRNTKRIDFYNAILMISEQKVGQKLPLLPQSSAENTMLRIVTLVNAKQFKQALRETEFSMRKSIIDFDMQRQKYQHLFAKELAHQYLQNLSKIAKKINCTSILQTLAYHEQQFLYKNVSYNQLLELTMRYADPRSNFYKHMHKKFVENINREYTHFYTAIYTRHISREVLDYAIDLLPNNYEFRWKRAQMHLYHMHYEKAAQDLSIAIRIQPQQKQAKLLRIIAHIGLMLQGKHSQQQIQKEIQKISPQQLSPQENVLLQAIYQVLNRQAVRINNRELQEIFRNLQYFAF
>NZ_AP019860.1|WP_151969173.1|4628409_4628928_-|YdcF-family-protein
MNTHHDALVVLGMVLDSSGKLNTLAQARVKLAATCYKKYNCPIVLSGGGMGEISEARCMLQALLDLQVPAQHIFLEEESLDTLGNAYFTKKQFLEKNNWFRIMVITSEFHVARTRKIFCGVLGKAFSITFLGAEDCISQQQKQQLYAMEKLFLEKLQLSDNFTTPPKRSDYK
>NZ_AP019860.1|WP_151969172.1|4628203_4628404_+|hypothetical-protein
MYRFNGVSMPGFGVGVLLAIVLGFVGYGFGKVLTISIATWIAIDVITIVQIVVSKKNEKNDAQELE
>NZ_AP019860.1|WP_151969171.1|4627423_4628191_+|ZIP-family-metal-transporter
MLNHIIWDAVFAGILASLACGLGVLPLYFKKIDNQKQIGIGYGFAGGLMFSASVYNLILPGLQMEGHQIEIVLALKVVAGILAGTFFIWLVERYMDTHESKTVENWGGKGVVLIFIAMCIHSIPEGVAVGVGYTSGELHSSSLGDYIALAIGIHNIPEGLAVAIPMRLAGMSLGRCFFMAVFTSIPQPLAAIPAVFLAWFFQPLMPSLMGFAAGAMIFLVILEMIPDALQQESAVKIAWAFIWGFCTMILLQIVL
>NZ_AP019860.1|WP_151969170.1|4626257_4627415_+|acetate/propionate-family-kinase
MSILVINSGSSSLKIKIFSDIDTPAIVHGNLEKIGEEHSALHCQFAQNKIDKQITCADHREGLEQFFTVLKDNNALVDITAIGHRVVHGGEDFSQPVKIDDNVIATIEKNIPLAPLHNPANLKGIEATMYMFPDVPQVAVFDTAFHQSVPEHAYRYAVPESFYKEQKIRSYGFHGSSHQYVSKEAARILQKPTEQTNLITLHLGNGASVAAIKNGKSIDTSMGMTPLEGLIMGTRCGDIDPGVLLFLLQKYSHDELDKILNKKSGLLGLCGSNDMRDIEAQNTEQSRLTIKMVVHRIQKYIGSFYAQLPELDAVVFTAGIGENSKLIRKLCCENLAHLGIELCDEKNNNVTCGEIQSSQSKVKILVIPTNEEMEIARQTYTLINV
>NZ_AP019860.1|WP_151969169.1|4624218_4626261_+|phosphate-acetyltransferase
MANNLYITTTEAQSGKSLITLGVMELLLQHIPNVGFFRPIIARDEDRDIEMIRSYFNLEFDYELMYGCKGERALDLITNGQQDVLLSQILEKYKVLEERCDFVLCEGTDYRGITSSFEFDINAEIATMLNCPVLLVINGKGKSLERINDSIRFSKEVFAEKECLVVATIINRLEGKYEEKDTYSIPENTILTSPTVSNVKNMLRAEVMYGEEYLNRNIEGYTVATSHKILPQLKNKHLVVTTGDREDVIFTSAVSFVAKKGKNVSGIVLSGNHALSEDVLMLLRNIEMFHVPILRCSDNIYSVIAQIQKMYSEITPYDERKVLTSLQIFERHINREALQQAIEFSKPHSITPKMFEYSLIAQARRDKVRIVLPEGNEERVLKAAEIVCKRDFAHLILLGNPQQITEKINRLDLNLDDVEIIDPKESPKLEEFAQQYYEMRKHKGLSLDVSREVVTNENYFGTLLVHNEEADGMVSGSVHTTAQTIRPALQIVGTSEGSSIVSSVFFMCLRNRVLVYGDCAINPNPTAEQLAEIAIASGETAKIFGIDPRIAMLSYSTGASGKGIDVEKVAQATQIAQDKNSGLLLEGPIQYDAAVDLEVAKTKLPDSKVAGRATVFVFPDLNTGNNTYKAVQRSTGALAIGPVLQGLKKPINDLSRGCTVTDIVNTIAITAIQAQRSRQS
>NZ_AP019860.1|WP_151969168.1|4623321_4624101_+|hypothetical-protein
MLKITDPESYHKYVAYVKEHYTPLHSHLYEFNKDVFAPSFRCVVDKKEDLLSTIVEIYPQIYSWELFTAEFCYEFIAEVRHFEKWCMENDIEKRLPNSMNNYGVVLGDFGFYDFLQQLMLEYIKPITTILYPDVGGDSLDYHHSFIVEYALNKDLCLDFHVDASDVTLNICLGNEFTGGDLYFGGIRCAWCQQTPPLKEEEIGVRHEPGHAILHRGKHRHSAQHIKSGERINMIMWCMSSRNQQTPLDECPTWCGNYYK
>NZ_AP019860.1|WP_151969179.1|4636976_4637930_+|hypothetical-protein
MDKSLSEKCTRFQNALDMFVSRVSEDKWIQAVVLIGEISEETIWHKERLFLWVIEVDNVTKRRKSDGGDERIFRTYVEDDINIVVELIPRTRFKLMVEGNSRTAFTHNFFAKRLVVHSKDPSIDRWFTQANQLATSDQDTALLIAMTWVIHPLKYIDKLINIKKDAELARQELIGVAHSLASIEIILRGEIYEHQLIYKALDYNPDLFSVVYEDILGRQRSFSKLKKALQTVRDYVHENDTRYLRPLIKFFKAHRQIVPLSHICDNFAHTQIYPWHIASACEWLADKGVLEKVSLPIRVTKKSTVDVEEPAYQWNES
>NZ_AP019860.1|WP_151969180.1|4637940_4640799_+|excinuclease-ABC-subunit-UvrA
MRKTLSVHGARENNLKDIDIEIPRDKLIVVTGVSGSGKSSLAFDTIYAEGQRRFLESMSSWAKRFVQQLKKPQVDFVNGLSPVVCIDQKTISKNPRSTVGTMTDIFDYMRMLFASMGTPRCPVCEEEIAVWSLYRMMEHLLSLPTGTEVEIRVPVLKIYNEDYAYLFETIRASGYRHVRIDGEKRDIGNEVELDEDCDYFIEVIADVFVIEKNIDKQIIASLEHANKVGAGFFSFHILSEIAKGKCDKFYGNCGCNKHRVLCCEMHHGWFTFNDAAGACNTCSGLGTSMRVHTPLLVPDPSRSLRDGAFVKEAIGCDKNTWGGRILESLARYYNFSLDAAFNKLEKSVVDILFYGTKGEKFPIVIPEGATQGKHHEGKQVSFSGIATNIEHRYNWYRKHGEASNWSEEYYRKIMVEQVCPDCKGARLKKQRCLVSIATKNIYELGEMPLEELRDFIGNIEAEAKHVEVLQTIQREIIGRLDTLINIGLNYLNLNRRSATLSGGESQRIRLSSQIGSGLMGMLYVLDEPSIGLHAKDNAKMIKTLRHLRDIGNTVIVVEHDEDTIRAADYVVEVGPGPGIHGGEVIMSGTVQDMIKDNNSITGQFLSGKKQIKSPEKRSKGNGQYIEIKGAEHNNLRKVNVKIPLGNFVCITGASGSGKSSLIHETLYKKLYALKYDSRVLSGKHRKLVGADNVDDVIHIDQSPIGRTSRSNPATYIGFYDNIRKLFASTTLAKERKYNASRFSFNVKGGRCEECKGEGTITTKLAFMPDVETTCPSCKGKRYNDETLEVMYHDKNIFDVLEMSIEEGATFFKDQKLIARKLSVLNDLGLGYLTVGHPAPILSGGEAQRVKLSAELSKSKRGKSNLYILDEPTTGLHFADIQKLLDCLRSFVDKGHSVVVIEHNLDVIKTADHIIDLGPEGGESGGEIMAVGTPEEVAKKKKSHTGRFLAKLL
>NZ_AP019860.1|WP_151969181.1|4641105_4645593_-|protein-kinase
MDYRDQCLAQWSYHLGYLPVEIYQKLQNSSVNFRQYCLQKKILTEKQFFNTQFFFILQFILQEAQKQEMLDNAQVASIINYRKQALQQNNFSPNLHFPQVPQFNMDHIATCVESLKSQGVFTNEDDQIYEQITNSTTQNPLEKSPGVFTKNDLGTFAVYKLEKQIGAGGMGRVYKAYHARLDRTVAIKVILGTQSTENQSRFLEEGKLTAKLHHPNIVTVHDMGTYQGQDYIVMDYIEGGSLSDLLAKKKLNIRRSLEIIKDVCYAMGYAHKSNIIHRDLKPSNIMMNNGDTPLVMDFGLAKNIENSSELTREGSVIGTPRYMAPEQAAGHIHRLSPATDVYSLGAILYQMITRKAVIDGQTPVEMIFSILHRDVIPPRKHNSKISKELESICLKALEKTPKDRYQNGREMAEDIERMLNGEAIEARRASFSYFLWKKVQRHKLPIAITTTISMLLLFTLGIMSYVNRQAQNKKSILVWQKWWERFTELAVQDQQTFGERKQRLETAFTIIEKLHQQYPQLCKEVRLDQYQEDKKIQDKITRWQKNDDALFSIWEYFQNCSDMIKKYSALQKEYEQNKREHSQVLAQAQHNFGNNDAIRSYATSNTPALSLAKNYQDKLSSLVKEISQIDLTKQRELSSKSLEKLRWKAQFIYRCDNANDKAQQTLRRITAITQNRYGLVLERILQLQKPTLYTLEAIRSELENIVLANSTFADSFYRIARLYHQQGDTFTAQIYYEKATRRFSDNHFFSLYYLGQIYSQRWHLLMGKRSAVKHQEKSISDKLDTQYVKVLKKHRKNMEDEINDIRDNFQQVQKKLEQIPSGSNQSYYRTMAKFYREIMKREDFVVREFDNVNAGSILHFYLCPQKKDSMEEFNKGLQKYRDLLKILESINQQNFIGETQLYRAKIYQDLMLLEGKGSYLQKVNNIIVNFEDAVKNQRMNVASWLGLARIYNMIGDFERAAYLYKQVAEADFAAQWQYILVRMGDKKLNDATRELERLLKKHPLQEKHTSFLAEVDGNPELKVLYNPPSPLEHLQMELNFLAFLYLRQGKLDKVKELMPRVFPLMSQSIQLNRRGKSYVCNLLFIIIALQMQNKKQAHMASRILWQTLAQSFPPLRQTNLLSSFLPWLQNYDNILIQHPKYRHPPKHIDTFINKLVKIDEELLYQVVNRSNLLKQIHIYLRDKPQLHKEYRILTGRVTGNEKSIDLAIFLLIKLGIDLTEKKILETNFVSALKVNYRKAIAHFRRSFSAKNKHEHLQNALDYMQLVIAEQPQQGEYHYAIAVILSQMSQRKNEMYEHLEWAKQLGWNLNYLKIDPLFADVSREKRFRSLFAKKSKTIAQISISDVNNKIQSLLKKKQPHKAMRLYNIFIKNNNVAVKNTYEKMVQQMTQLFVGKAKRNLDSPQKIEQICYEIKHTVAKDSVKILHKIAMLYTNRGKGYISRQELRMAKDDLNTAIKIDPLCYKAYKYRGEVYKKQNKPQQAQQDFATYRRLKKEE
>NZ_AP019860.1|WP_151969182.1|4646051_4647452_+|RRXRR-domain-containing-protein
MQRRVFVLSKNRKPLMPCSAARARQLLKERKASVYRQEPFTIILQKRTEGDLQKVQLKFDPGSKITGMALVVFFQKGTVVTWAAELEHRGEKIVDLLSKRRAIRRSRRNRKTRYRPPRFCNRTRKKGWIAPSLKSKVDNIFNWTKKLLTYAPIDNLCVETNRFDTQKLQNPEISGVMYQQGTLFGYEIREYLLYKWNHQCAYCDAKNVALEIDHIHPRSKGGSNRVSNLTISCRKCNENKGNGDIHNFLSKDNKRLQKIVSYSKKTLRDAASINTTRYVIGNQLKKLGIDVEFASGGKTKANRRHNGFSKQHWIDAACAGESGENVTISQDLIPLGIQSQGRGSRQMCRVDQFGFPRTTAKSQKRVKGFQTGDIVKAVVTKGKKKGVYVGRVAVRSNGYFNIKTNNSTVQGISYRYCHLIQQVDGYFYFQKGDARLKKASCSCFAHSCPSGDSSPTYRSRGILAIN
>NZ_AP019860.1|WP_151969183.1|4647451_4649719_+|tetratricopeptide-repeat-protein
MKYGNYTIEEELGRGGMGIVYKAYDAHLRRHVALKVVTEGSLERFEREYRALAQLQHPNIVTFYEYGMLPKPFFAMEYVVGETLEKKIAEKSLERSKLIDFIIDVCEGLQEAHNKNIFHRDIKPANIIIDTKNRAKIMDFGIAKSNVDEEEKLSKTGYMVGTLLYMSPEQIAGEFSTQTDIYSLGVCIYEAITGRTPYQGTSQINIAYAIQNQDPIRPREFNTSISPYLEAICMKCLARAPKKRYKSMRQLARDLKNFKEQKPIIAKRITYLDQMKSTVKNNKSLFTLIGVFIVFLLTFGLYFAVKEQKLREINSELHVLNQAMNKFTQNILSSDYQDLFARREITTPLYEAFKQSSYLKNAEEHIFLRGVVYGNRPDKKDKEQALRDFKKIIKKYPETFVAYRNIGVLYQQLGEEKKALFYFEKARKLNPQDAKSTYAVAMRLFRSKQHEESLKNFLHAVELSPRNAQYRYELGLLYNALNKQKKAFASFEKAIDLQPHFAAAYRERAILFFRFNQLDKAIADLNRAISLGLRKADTYCDLGSLYLEKKQYDAAQLNCQKAIELDVTHVRSYYTMGLVHQRLKKYTKAVKYYSKSIELEPQIFSYLNRGNVYRDLEQYSKAVDDYIKAISIKSYYPAHANLAAVYNIIGLYEKAIEQATVAIRLQSKYEEYYQRGLAYHKLRMYNKSIKDYDKAIELGSALPAVSKVYDKRGDVYFAIGDHRRAIDNWQKVVALIPATRPEMVKKIAKARQRRK
>NZ_AP019860.1|WP_151969184.1|4649856_4650069_+|MbtH-family-NRPS-accessory-protein
MSEYKDWQDGELKVVVNHEEQYSIWPADREAPEGWREVGVRGDKATCLEYIEKHWTDMRPLSLRKQMDGG
>NZ_AP019860.1|WP_151969185.1|4650156_4650735_-|PEP-CTERM-sorting-domain-containing-protein
MKKLIALLAMSFICVSLYAESFTIGNTQPGTFFFIQGQSFTPNVQGNEGTGIATPNPDGNILLTSFSLDFVNAATAPGEIHIFASAPTLAQAASGTGSIGTGTHVGGGVYDFGPGLLIPFFAKSFAVLPNSAEIFDAPNAYAGGADLFPIGGFVNEGGFDAGFNATFQTVPEPSTYLMFLILGACVITRRKR
>NZ_AP019860.1|WP_151969186.1|4650949_4653403_-|hypothetical-protein
MRILLCSILLANHLLLALSTNEAKTLISQAASFSSEDMTSAKQKPLSLLLLNLNLHLEKQINPDVVKDFSYFKIENIDRQEMLAAIRHERQNTYSFVYPQHIVKCEFKLDGNVASGQFTFEIKDLYRGTALFNAQRHDEKWRITSFTLPNYGLRVYHEQKKWQTACLPTRFVIVRFAQNAIYTSNWFESDMDNEQKICDLDNLKNCETWLKNFAQKSTRQKISQMKMVIHASKALWDKVKGFIALVAKHNIYKLYFTHDRKTIVQNYLPMDVGVSSSNHQTRPKIIIMVNNNVFSIGKNSFSGQENYKLLTAHLQSLLKPLSSSEIAFEIRASNETPYGNIVRILDLCRNTADGMQKTSVIKFSLYAPTTSDVEVHEEAIGIIEKIPIEKSKAVVEDPVIEDPVIEDPVLKEVEEDHYETFDESYAHDRLSDRPFGDNPFGGNSRIDAIGVGGGAGSFGALGSFGPHFGGKLPRITDDQRVKEIEEAICAGLTWLKNHQQADGSWKAATFSDFCKTTPCRGFGTEEMDTKVTALALLCLVNSEERTFAKLKLKRHARSAARYLCRLQSDEGCFDQKGYDYMHHHAIATLALCKLYQKIYSPVLRICIQKAVDFMIKAQNAESGWGHTSQSGRSNTSVTSWCVIALTEAAKTDFVVPRDFYSGVKKWLSATTDEHYSRTGYMQKGDTGPRLQNAPNFLPVETMTAAAICIRTALGMSRSENNNSAVLVESNLPTWKENDNRKSTIDYCYWFYGTVAMRHMKGDFWQKWRKALLPILLEKQCPNDCKKGSWPAIDAWSKAGGRVQATAFNTLSLQMFYR
>NZ_AP019860.1|WP_151969187.1|4653673_4654783_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MRIIVRIILRILEAIVVFALCCLCFFAAKPDYFTTEEQKKVKRTSETPPVRVVTRSVQFLANDRVFQATGTSIARKSVWIYSPVAAQVTSVNFTAQKRVKKGALLLQLDDREERLALQLAKVELQNAEKVLTRYRRTIGGRAVSANEIDAARLGFDAAKVRLEQAKFAVSERKIIAPFTGVVGISRVDLGDRIATNTIITSLDDRSGIYVDFQVPELLAGSLSPNLKAEMTTPAFPGKTFIGTITDVESRFDVQTRTVRIRVSIDNSNDMLRPGMSFAIKLHLKGKIFPAVPEISLKWGREGAYVWLIKNSKAQKTTARVVARTNQQVLVDAQIEEGDIVVIEGTQRLREGREVVNDSEKEQEYNGPTR
>NZ_AP019860.1|WP_151969188.1|4654766_4657871_+|efflux-RND-transporter-permease-subunit
MDRQGKNFSALVVRRPVLIIVINLLIIIAGGAAMFGIDIRELPNVDRPTVSVRAFYDGASPETMDAEVTRVIEGAIARVNGVRNIRSSSEENNCRIRIEFQPGVDLTDAANDIREAINRNRRQLPEDVEEVFVVKADDDAEPIIQLSAVSNTLSKDELAQKIEKDIMPAFLSIQGVAEVRLSGNQKRELRVLLKPTQMAKLKINVSLVENVLRNARLDIPAGSYKSGDQELLVRANASMSTPQQIRKLILRDNVYLEDIAVVFFAPEEAESYARLNGSIVIGLDVVRQAGANTINISKDVDKQVDKINRRNRDVEIIKTADDAIFIEGAIKEVLVSLLFSVGIVILVIVLFIGSVRATLVPAVAIPISLIGTFSAIWLMGLSINLLTLLALVLATGLIVDDAIVVLENIQRHQKNGVKSMAAAVIGSQQVFFAVIATTVTLVSVFLPITFLPSQAGKLFREFGLVLSVSVIISSIVALTLCPMMASRLTIAEAEKTWFPMTKGILNFCGQIFSHFYRFSLKICIKFPVICLLSILVLCCGSWPVFQSLKQELVPKEDRGSVRIMLTGPDGASLPYSDRQAEKLEAIMYPYYKQGIITNIYTTVGQYDKNRSSIVATLKHWEERDINQLELTKEIQERLGEIPGAQARVRGGNSLGVRGGRGGLNIALLGNNYSEISAAADALVLAVESLPEVTDTRADFDTSQPELAFTINRRKTNDLGVDIVDIARTLRAMVDGYEVARLNIDDEEVPIILGSVDGAADDPEDLLNVFMVNDQQNLIPLLSFVDIKESGIAAELDRHKQRRAIEVDIGLKPDAVLSEVVREVEKIGEEILPSGVNILLLGDAADLGETSYELSITFGLAILIVFLVLAAQFESIGSAFIVIFTVPFGLSAAVYALYFTGQSINLYSQIGLVMLVGLMTKNSILFVEFMDQLREEGAEVKEAILRGAQIRLRPVMMTVLSTVVGSLPLVLSSGPGSEARSAIGWVIFGGLGLATFLTLYLTPIGYALIAPFVKPRSHAQKILETQLQEVQKIAS

Crispr_ID: NZ_AP019860_21

• CRISPR_ID: NZ_AP019860_21
• CRISPR_location: 4636185-4636491
• CRISPR_type: TypeV
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_AP019860_21

Consensus_repeat	Method
TCAAATCTAAGTGAGTAAGAGAAGAGAG	CRISPRCasFinder

spacers of NZ_AP019860_21

>21.1|4636213|44|NZ_AP019860|CRISPRCasFinder
TTGTCCGATTTGTGGTGGTAACTCACTTAGTTCTGTGGTGTAGC
>21.2|4636285|41|NZ_AP019860|CRISPRCasFinder
CTGTCCAATCTGTAATGGTAATTCGGTTATGTCTGTCGCTT
>21.3|4636354|41|NZ_AP019860|CRISPRCasFinder
ATGTGCGATCTCATTTGGTAATTCCGCTATGTCTGTGGCCC
>21.4|4636423|41|NZ_AP019860|CRISPRCasFinder
TTGGGCAATTTTTTTGGGTAGGATGGCTATTTTTGTATTGG

CRISPR arrays and Neighbor proteins around NZ_AP019860_21

CRISPR arrays

The CRISPR arrays of NZ_AP019860_21

>merge|NZ_AP019860|21|4636185-4636491|CRISPRCasFinder
TCAAATCTAAGTGAGTAAGAGAAGAGAGTTGTCCGATTTGTGGTGGTAACTCACTTAGTTCTGTGGTGTAGCTCAAATCTAAATGAGTAAGAGAAGAGAGCTGTCCAATCTGTAATGGTAATTCGGTTATGTCTGTCGCTTCCAGATTCAAGTGCGTAAGAGAAGTAAGATGTGCGATCTCATTTGGTAATTCCGCTATGTCTGTGGCCCCCAAATTCAAGTGAGTAAGACAGCTTAGTTGGGCAATTTTTTTGGGTAGGATGGCTATTTTTGTATTGGCAACATCTAGGTGTGTAAGAGAAGTAAG

>NZ_AP019860|21|17|4636185-4636491|CRISPRCasFinder
TCAAATCTAAGTGAGTAAGAGAAGAGAG	TTGTCCGATTTGTGGTGGTAACTCACTTAGTTCTGTGGTGTAGC
TCAAATCTAAATGAGTAAGAGAAGAGAG	CTGTCCAATCTGTAATGGTAATTCGGTTATGTCTGTCGCTT
CCAGATTCAAGTGCGTAAGAGAAGTAAG	ATGTGCGATCTCATTTGGTAATTCCGCTATGTCTGTGGCCC
CCAAATTCAAGTGAGTAAGACAGCTTAG	TTGGGCAATTTTTTTGGGTAGGATGGCTATTTTTGTATTGG
CAACATCTAGGTGTGTAAGAGAAGTAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151969177.1|4635224_4635716_-|GFA-family-protein	unknown	unknown	gnl|CDD|226314
NZ_AP019860.1|WP_151969170.1|4626257_4627415_+|acetate/propionate-family-kinase	unknown	unknown	gnl|CDD|234680
NZ_AP019860.1|WP_151969169.1|4624218_4626261_+|phosphate-acetyltransferase	unknown	unknown	gnl|CDD|235537
NZ_AP019860.1|WP_151969180.1|4637940_4640799_+|excinuclease-ABC-subunit-UvrA	unknown	unknown	gnl|CDD|234734
NZ_AP019860.1|WP_151969171.1|4627423_4628191_+|ZIP-family-metal-transporter	unknown	unknown	gnl|CDD|223505
NZ_AP019860.1|WP_151969185.1|4650156_4650735_-|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|131644
NZ_AP019860.1|WP_151969181.1|4641105_4645593_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969174.1|4628939_4633823_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969184.1|4649856_4650069_+|MbtH-family-NRPS-accessory-protein	unknown	unknown	gnl|CDD|225790
NZ_AP019860.1|WP_151969175.1|4633884_4634466_-|hypothetical-protein	unknown	unknown	gnl|CDD|180941
NZ_AP019860.1|WP_151969172.1|4628203_4628404_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969188.1|4654766_4657871_+|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl|CDD|223911
NZ_AP019860.1|WP_151969179.1|4636976_4637930_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969173.1|4628409_4628928_-|YdcF-family-protein	unknown	unknown	gnl|CDD|99750
NZ_AP019860.1|WP_151969187.1|4653673_4654783_+|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NZ_AP019860.1|WP_151969168.1|4623321_4624101_+|hypothetical-protein	unknown	unknown	gnl|CDD|214780
NZ_AP019860.1|WP_151969183.1|4647451_4649719_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969176.1|4634784_4635192_+|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|224276
NZ_AP019860.1|WP_151969186.1|4650949_4653403_-|hypothetical-protein	unknown	unknown	gnl|CDD|238362
NZ_AP019860.1|WP_151969182.1|4646051_4647452_+|RRXRR-domain-containing-protein	unknown	unknown	gnl|CDD|379519

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151969177.1|4635224_4635716_-|GFA-family-protein	gnl|CDD|226314	COG3791, COG3791, Uncharacterized conserved protein [Function unknown].	6.24064e-10
NZ_AP019860.1|WP_151969170.1|4626257_4627415_+|acetate/propionate-family-kinase	gnl|CDD|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
NZ_AP019860.1|WP_151969169.1|4624218_4626261_+|phosphate-acetyltransferase	gnl|CDD|235537	PRK05632, PRK05632, phosphate acetyltransferase; Reviewed.	0
NZ_AP019860.1|WP_151969180.1|4637940_4640799_+|excinuclease-ABC-subunit-UvrA	gnl|CDD|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
NZ_AP019860.1|WP_151969171.1|4627423_4628191_+|ZIP-family-metal-transporter	gnl|CDD|223505	COG0428, COG0428, Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism].	5.45356e-37
NZ_AP019860.1|WP_151969185.1|4650156_4650735_-|PEP-CTERM-sorting-domain-containing-protein	gnl|CDD|131644	TIGR02595, conserved_hypothetical_protein, PEP-CTERM protein-sorting domain. This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures].	9.21067e-05
NZ_AP019860.1|WP_151969181.1|4641105_4645593_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.21987e-98
NZ_AP019860.1|WP_151969174.1|4628939_4633823_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.12531e-96
NZ_AP019860.1|WP_151969184.1|4649856_4650069_+|MbtH-family-NRPS-accessory-protein	gnl|CDD|225790	COG3251, COG3251, Uncharacterized protein conserved in bacteria [Function unknown].	3.63944e-24
NZ_AP019860.1|WP_151969175.1|4633884_4634466_-|hypothetical-protein	gnl|CDD|180941	PRK07352, PRK07352, F0F1 ATP synthase subunit B; Validated.	0.00198629
NZ_AP019860.1|WP_151969188.1|4654766_4657871_+|efflux-RND-transporter-permease-subunit	gnl|CDD|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_AP019860.1|WP_151969173.1|4628409_4628928_-|YdcF-family-protein	gnl|CDD|99750	cd06259, YdcF-like, YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been idenitified. The family also includes Escherichia coli sanA and Salmonella typhimurium sfiX, which are involved in vancomycin resistance; sfiX may also be involved in murein synthesis.	1.70333e-31
NZ_AP019860.1|WP_151969187.1|4653673_4654783_+|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	4.72324e-58
NZ_AP019860.1|WP_151969168.1|4623321_4624101_+|hypothetical-protein	gnl|CDD|214780	smart00702, P4Hc, Prolyl 4-hydroxylase alpha subunit homologues. Mammalian enzymes catalyse hydroxylation of collagen, for example. Prokaryotic enzymes might catalyse hydroxylation of antibiotic peptides. These are 2-oxoglutarate-dependent dioxygenases, requiring 2-oxoglutarate and dioxygen as cosubstrates and ferrous iron as a cofactor.	8.77353e-20
NZ_AP019860.1|WP_151969183.1|4647451_4649719_+|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.69386e-98
NZ_AP019860.1|WP_151969176.1|4634784_4635192_+|pentapeptide-repeat-containing-protein	gnl|CDD|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	2.74414e-21
NZ_AP019860.1|WP_151969186.1|4650949_4653403_-|hypothetical-protein	gnl|CDD|238362	cd00688, ISOPREN_C2_like, This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.	4.47145e-12
NZ_AP019860.1|WP_151969182.1|4646051_4647452_+|RRXRR-domain-containing-protein	gnl|CDD|379519	pfam14239, RRXRR, RRXRR protein. This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with pfam01844.	1.0687e-84

Protein sequences

>NZ_AP019860.1|WP_151969177.1|4635224_4635716_-|GFA-family-protein
MTTHFGEEYASVNDENFKAKYRASCYCGAICYEVQDDPVDAKICHCIACQKLHGAPMQWAAIFYKRDVRITAGVENMEFYNSELHKHERILPCKVSCKKCKTLIADEGRNMWLAFPSLFDFGSPPRIPEKFRPTCHIFYGMRSMDVEDGATKWSGHKNKSQRL
>NZ_AP019860.1|WP_151969176.1|4634784_4635192_+|pentapeptide-repeat-containing-protein
MIFFRKKNSIEDENLVGANLSNQYLKNVNLSGVNLERVDLSRSNLKNSQLSGANLKNANLSYAKLEKSDLSGANLSGANLKNADLSGVDLSGANLSGANLKKVNLKGANLSDVDLTGTNLTNACLFGTNLADTDL
>NZ_AP019860.1|WP_151969175.1|4633884_4634466_-|hypothetical-protein
MYRIILLLLIATLVYPSVCYPQENIIQTEELQEIISYVKKMHHTTKSIQKDTHKNFQETITLLEKLKSSYDNLPEFVKNITEEKRSGIKEDNTQNIEKSLRIAAKDISQAAKDLNQVAKTVDKATSHIRQTAKDINNAAQTLKKIASRLSQMTNNVKKVTDETLDSVEKIHKKLHGSSRTSHCKTQETTRDNK
>NZ_AP019860.1|WP_151969174.1|4628939_4633823_-|protein-kinase
MTPQEKQFLEKALVANLIDQQQAQHAIRLQQQTEQQGKNASIAQCLQHLKYLSANQIQHLQQSTGVGEHAMTQQFPQTKEAKFGRYTIISELGRGGMGKVYKAYDPNLDRVVALKMLLTDQDQHAIDRFMREAQATAKLKHANIITLYDIGIEDSQPYFTMEFIEGDSLEQMAKKSTMSNHQIAILMATVADAVHYANKQGIIHRDLKPDNIMMKDNTPIVMDFGIAKLDKAQKKLSKTGMIVGTLQYMAPEQAAGKNRAVDQRSDVYSLGAILYRLLTGHKMFPAGSQIYILNQILNHDPVPPSKHKKIIARDLENICLKAVEKKQSDRYQSAKELSEDLRAFGAGETVKASPTTWQRKLWRKCKRYRAHIAVAIIALIVTNLYFSSLSGSVTISPRNEHGEFISPKAILINGKKIAQTQLKNHYIAPGNYNITLKFNDYQDVACENVAITAGDDNTQIIDVKPKKGEISLTSSLSEVKASFVHDKNQKETTFAVPAQEKLATGNYTVTFSKLNHFSYKHHLTVDNKKKTINSDLRPMILWRKEINYNVVSNGMTLAHLGDSLELIVSDRGGKINSYGYPNFFPKWEIPLKLDIATPRQKITTHDFNKDGIMDLIVANYAQFMVFDGKTKQQIFRWYPFWDHKFIIADANDDAYEDIVLLTRYHGIRIFYSHQGSFDSQKRFSHINTSVSGLSHPLLLNKSTVLCASANTVLHVDLQKRKVRSIYTHGSDILDIKIAKTTKQKLLLLYDSQKLISLDLDTLRTKETIHEFPTPHRINEMSMIDIDNDGNEEVLFQRDQLYCVDIHNKKIKWQLNTQNDFFEGSPVFVSDLDHDGKLEVVTWTRQQTAGQKSTNTIFVVDHQGNEQQKAVIDDEIVSMVFVDTNQDHRLEVLFLAGSAIHCLEYYPANTSPQVSTFSRNLPAMAIPPVAADLNGDKIKELIIIDELGYLHCLDGSNKQSLWKTDRSLNVMRATTADFDGNGEVEVFAVGKKNIALLSKDGEAIWKSPIVIDIVNSPIAVDVDGDHYKEIICYKRAPARVHCIDIKERKVRWQAAKKQGLQVIHGTAQAQDVNNDGTQEIFILSGYQVHCLDGPSGRVRWSQPVPNIGEGGQIVSCRVRGKTLIFAGQVAGFISCFDALSGKKHWHKNVLSGDIRTVVLHQISGRQCIAFTTANDEVFCLDAFSGEIVWQRKITPRYYLENVQQPRTYAQIIALNVDVNADGVNDLVTTCSTHTFYTLSGIDGSWLGDTNAFTKVERLPRILDLDGDHKQDMLFVDRHLQIFSMNDIEKYFSHLLHVPQQFTTLDQDSEALYLHYLDNLVKHRKYSLLQKQLPAVKNKLRNTKRIDFYNAILMISEQKVGQKLPLLPQSSAENTMLRIVTLVNAKQFKQALRETEFSMRKSIIDFDMQRQKYQHLFAKELAHQYLQNLSKIAKKINCTSILQTLAYHEQQFLYKNVSYNQLLELTMRYADPRSNFYKHMHKKFVENINREYTHFYTAIYTRHISREVLDYAIDLLPNNYEFRWKRAQMHLYHMHYEKAAQDLSIAIRIQPQQKQAKLLRIIAHIGLMLQGKHSQQQIQKEIQKISPQQLSPQENVLLQAIYQVLNRQAVRINNRELQEIFRNLQYFAF
>NZ_AP019860.1|WP_151969173.1|4628409_4628928_-|YdcF-family-protein
MNTHHDALVVLGMVLDSSGKLNTLAQARVKLAATCYKKYNCPIVLSGGGMGEISEARCMLQALLDLQVPAQHIFLEEESLDTLGNAYFTKKQFLEKNNWFRIMVITSEFHVARTRKIFCGVLGKAFSITFLGAEDCISQQQKQQLYAMEKLFLEKLQLSDNFTTPPKRSDYK
>NZ_AP019860.1|WP_151969172.1|4628203_4628404_+|hypothetical-protein
MYRFNGVSMPGFGVGVLLAIVLGFVGYGFGKVLTISIATWIAIDVITIVQIVVSKKNEKNDAQELE
>NZ_AP019860.1|WP_151969171.1|4627423_4628191_+|ZIP-family-metal-transporter
MLNHIIWDAVFAGILASLACGLGVLPLYFKKIDNQKQIGIGYGFAGGLMFSASVYNLILPGLQMEGHQIEIVLALKVVAGILAGTFFIWLVERYMDTHESKTVENWGGKGVVLIFIAMCIHSIPEGVAVGVGYTSGELHSSSLGDYIALAIGIHNIPEGLAVAIPMRLAGMSLGRCFFMAVFTSIPQPLAAIPAVFLAWFFQPLMPSLMGFAAGAMIFLVILEMIPDALQQESAVKIAWAFIWGFCTMILLQIVL
>NZ_AP019860.1|WP_151969170.1|4626257_4627415_+|acetate/propionate-family-kinase
MSILVINSGSSSLKIKIFSDIDTPAIVHGNLEKIGEEHSALHCQFAQNKIDKQITCADHREGLEQFFTVLKDNNALVDITAIGHRVVHGGEDFSQPVKIDDNVIATIEKNIPLAPLHNPANLKGIEATMYMFPDVPQVAVFDTAFHQSVPEHAYRYAVPESFYKEQKIRSYGFHGSSHQYVSKEAARILQKPTEQTNLITLHLGNGASVAAIKNGKSIDTSMGMTPLEGLIMGTRCGDIDPGVLLFLLQKYSHDELDKILNKKSGLLGLCGSNDMRDIEAQNTEQSRLTIKMVVHRIQKYIGSFYAQLPELDAVVFTAGIGENSKLIRKLCCENLAHLGIELCDEKNNNVTCGEIQSSQSKVKILVIPTNEEMEIARQTYTLINV
>NZ_AP019860.1|WP_151969169.1|4624218_4626261_+|phosphate-acetyltransferase
MANNLYITTTEAQSGKSLITLGVMELLLQHIPNVGFFRPIIARDEDRDIEMIRSYFNLEFDYELMYGCKGERALDLITNGQQDVLLSQILEKYKVLEERCDFVLCEGTDYRGITSSFEFDINAEIATMLNCPVLLVINGKGKSLERINDSIRFSKEVFAEKECLVVATIINRLEGKYEEKDTYSIPENTILTSPTVSNVKNMLRAEVMYGEEYLNRNIEGYTVATSHKILPQLKNKHLVVTTGDREDVIFTSAVSFVAKKGKNVSGIVLSGNHALSEDVLMLLRNIEMFHVPILRCSDNIYSVIAQIQKMYSEITPYDERKVLTSLQIFERHINREALQQAIEFSKPHSITPKMFEYSLIAQARRDKVRIVLPEGNEERVLKAAEIVCKRDFAHLILLGNPQQITEKINRLDLNLDDVEIIDPKESPKLEEFAQQYYEMRKHKGLSLDVSREVVTNENYFGTLLVHNEEADGMVSGSVHTTAQTIRPALQIVGTSEGSSIVSSVFFMCLRNRVLVYGDCAINPNPTAEQLAEIAIASGETAKIFGIDPRIAMLSYSTGASGKGIDVEKVAQATQIAQDKNSGLLLEGPIQYDAAVDLEVAKTKLPDSKVAGRATVFVFPDLNTGNNTYKAVQRSTGALAIGPVLQGLKKPINDLSRGCTVTDIVNTIAITAIQAQRSRQS
>NZ_AP019860.1|WP_151969168.1|4623321_4624101_+|hypothetical-protein
MLKITDPESYHKYVAYVKEHYTPLHSHLYEFNKDVFAPSFRCVVDKKEDLLSTIVEIYPQIYSWELFTAEFCYEFIAEVRHFEKWCMENDIEKRLPNSMNNYGVVLGDFGFYDFLQQLMLEYIKPITTILYPDVGGDSLDYHHSFIVEYALNKDLCLDFHVDASDVTLNICLGNEFTGGDLYFGGIRCAWCQQTPPLKEEEIGVRHEPGHAILHRGKHRHSAQHIKSGERINMIMWCMSSRNQQTPLDECPTWCGNYYK
>NZ_AP019860.1|WP_151969179.1|4636976_4637930_+|hypothetical-protein
MDKSLSEKCTRFQNALDMFVSRVSEDKWIQAVVLIGEISEETIWHKERLFLWVIEVDNVTKRRKSDGGDERIFRTYVEDDINIVVELIPRTRFKLMVEGNSRTAFTHNFFAKRLVVHSKDPSIDRWFTQANQLATSDQDTALLIAMTWVIHPLKYIDKLINIKKDAELARQELIGVAHSLASIEIILRGEIYEHQLIYKALDYNPDLFSVVYEDILGRQRSFSKLKKALQTVRDYVHENDTRYLRPLIKFFKAHRQIVPLSHICDNFAHTQIYPWHIASACEWLADKGVLEKVSLPIRVTKKSTVDVEEPAYQWNES
>NZ_AP019860.1|WP_151969180.1|4637940_4640799_+|excinuclease-ABC-subunit-UvrA
MRKTLSVHGARENNLKDIDIEIPRDKLIVVTGVSGSGKSSLAFDTIYAEGQRRFLESMSSWAKRFVQQLKKPQVDFVNGLSPVVCIDQKTISKNPRSTVGTMTDIFDYMRMLFASMGTPRCPVCEEEIAVWSLYRMMEHLLSLPTGTEVEIRVPVLKIYNEDYAYLFETIRASGYRHVRIDGEKRDIGNEVELDEDCDYFIEVIADVFVIEKNIDKQIIASLEHANKVGAGFFSFHILSEIAKGKCDKFYGNCGCNKHRVLCCEMHHGWFTFNDAAGACNTCSGLGTSMRVHTPLLVPDPSRSLRDGAFVKEAIGCDKNTWGGRILESLARYYNFSLDAAFNKLEKSVVDILFYGTKGEKFPIVIPEGATQGKHHEGKQVSFSGIATNIEHRYNWYRKHGEASNWSEEYYRKIMVEQVCPDCKGARLKKQRCLVSIATKNIYELGEMPLEELRDFIGNIEAEAKHVEVLQTIQREIIGRLDTLINIGLNYLNLNRRSATLSGGESQRIRLSSQIGSGLMGMLYVLDEPSIGLHAKDNAKMIKTLRHLRDIGNTVIVVEHDEDTIRAADYVVEVGPGPGIHGGEVIMSGTVQDMIKDNNSITGQFLSGKKQIKSPEKRSKGNGQYIEIKGAEHNNLRKVNVKIPLGNFVCITGASGSGKSSLIHETLYKKLYALKYDSRVLSGKHRKLVGADNVDDVIHIDQSPIGRTSRSNPATYIGFYDNIRKLFASTTLAKERKYNASRFSFNVKGGRCEECKGEGTITTKLAFMPDVETTCPSCKGKRYNDETLEVMYHDKNIFDVLEMSIEEGATFFKDQKLIARKLSVLNDLGLGYLTVGHPAPILSGGEAQRVKLSAELSKSKRGKSNLYILDEPTTGLHFADIQKLLDCLRSFVDKGHSVVVIEHNLDVIKTADHIIDLGPEGGESGGEIMAVGTPEEVAKKKKSHTGRFLAKLL
>NZ_AP019860.1|WP_151969181.1|4641105_4645593_-|protein-kinase
MDYRDQCLAQWSYHLGYLPVEIYQKLQNSSVNFRQYCLQKKILTEKQFFNTQFFFILQFILQEAQKQEMLDNAQVASIINYRKQALQQNNFSPNLHFPQVPQFNMDHIATCVESLKSQGVFTNEDDQIYEQITNSTTQNPLEKSPGVFTKNDLGTFAVYKLEKQIGAGGMGRVYKAYHARLDRTVAIKVILGTQSTENQSRFLEEGKLTAKLHHPNIVTVHDMGTYQGQDYIVMDYIEGGSLSDLLAKKKLNIRRSLEIIKDVCYAMGYAHKSNIIHRDLKPSNIMMNNGDTPLVMDFGLAKNIENSSELTREGSVIGTPRYMAPEQAAGHIHRLSPATDVYSLGAILYQMITRKAVIDGQTPVEMIFSILHRDVIPPRKHNSKISKELESICLKALEKTPKDRYQNGREMAEDIERMLNGEAIEARRASFSYFLWKKVQRHKLPIAITTTISMLLLFTLGIMSYVNRQAQNKKSILVWQKWWERFTELAVQDQQTFGERKQRLETAFTIIEKLHQQYPQLCKEVRLDQYQEDKKIQDKITRWQKNDDALFSIWEYFQNCSDMIKKYSALQKEYEQNKREHSQVLAQAQHNFGNNDAIRSYATSNTPALSLAKNYQDKLSSLVKEISQIDLTKQRELSSKSLEKLRWKAQFIYRCDNANDKAQQTLRRITAITQNRYGLVLERILQLQKPTLYTLEAIRSELENIVLANSTFADSFYRIARLYHQQGDTFTAQIYYEKATRRFSDNHFFSLYYLGQIYSQRWHLLMGKRSAVKHQEKSISDKLDTQYVKVLKKHRKNMEDEINDIRDNFQQVQKKLEQIPSGSNQSYYRTMAKFYREIMKREDFVVREFDNVNAGSILHFYLCPQKKDSMEEFNKGLQKYRDLLKILESINQQNFIGETQLYRAKIYQDLMLLEGKGSYLQKVNNIIVNFEDAVKNQRMNVASWLGLARIYNMIGDFERAAYLYKQVAEADFAAQWQYILVRMGDKKLNDATRELERLLKKHPLQEKHTSFLAEVDGNPELKVLYNPPSPLEHLQMELNFLAFLYLRQGKLDKVKELMPRVFPLMSQSIQLNRRGKSYVCNLLFIIIALQMQNKKQAHMASRILWQTLAQSFPPLRQTNLLSSFLPWLQNYDNILIQHPKYRHPPKHIDTFINKLVKIDEELLYQVVNRSNLLKQIHIYLRDKPQLHKEYRILTGRVTGNEKSIDLAIFLLIKLGIDLTEKKILETNFVSALKVNYRKAIAHFRRSFSAKNKHEHLQNALDYMQLVIAEQPQQGEYHYAIAVILSQMSQRKNEMYEHLEWAKQLGWNLNYLKIDPLFADVSREKRFRSLFAKKSKTIAQISISDVNNKIQSLLKKKQPHKAMRLYNIFIKNNNVAVKNTYEKMVQQMTQLFVGKAKRNLDSPQKIEQICYEIKHTVAKDSVKILHKIAMLYTNRGKGYISRQELRMAKDDLNTAIKIDPLCYKAYKYRGEVYKKQNKPQQAQQDFATYRRLKKEE
>NZ_AP019860.1|WP_151969182.1|4646051_4647452_+|RRXRR-domain-containing-protein
MQRRVFVLSKNRKPLMPCSAARARQLLKERKASVYRQEPFTIILQKRTEGDLQKVQLKFDPGSKITGMALVVFFQKGTVVTWAAELEHRGEKIVDLLSKRRAIRRSRRNRKTRYRPPRFCNRTRKKGWIAPSLKSKVDNIFNWTKKLLTYAPIDNLCVETNRFDTQKLQNPEISGVMYQQGTLFGYEIREYLLYKWNHQCAYCDAKNVALEIDHIHPRSKGGSNRVSNLTISCRKCNENKGNGDIHNFLSKDNKRLQKIVSYSKKTLRDAASINTTRYVIGNQLKKLGIDVEFASGGKTKANRRHNGFSKQHWIDAACAGESGENVTISQDLIPLGIQSQGRGSRQMCRVDQFGFPRTTAKSQKRVKGFQTGDIVKAVVTKGKKKGVYVGRVAVRSNGYFNIKTNNSTVQGISYRYCHLIQQVDGYFYFQKGDARLKKASCSCFAHSCPSGDSSPTYRSRGILAIN
>NZ_AP019860.1|WP_151969183.1|4647451_4649719_+|tetratricopeptide-repeat-protein
MKYGNYTIEEELGRGGMGIVYKAYDAHLRRHVALKVVTEGSLERFEREYRALAQLQHPNIVTFYEYGMLPKPFFAMEYVVGETLEKKIAEKSLERSKLIDFIIDVCEGLQEAHNKNIFHRDIKPANIIIDTKNRAKIMDFGIAKSNVDEEEKLSKTGYMVGTLLYMSPEQIAGEFSTQTDIYSLGVCIYEAITGRTPYQGTSQINIAYAIQNQDPIRPREFNTSISPYLEAICMKCLARAPKKRYKSMRQLARDLKNFKEQKPIIAKRITYLDQMKSTVKNNKSLFTLIGVFIVFLLTFGLYFAVKEQKLREINSELHVLNQAMNKFTQNILSSDYQDLFARREITTPLYEAFKQSSYLKNAEEHIFLRGVVYGNRPDKKDKEQALRDFKKIIKKYPETFVAYRNIGVLYQQLGEEKKALFYFEKARKLNPQDAKSTYAVAMRLFRSKQHEESLKNFLHAVELSPRNAQYRYELGLLYNALNKQKKAFASFEKAIDLQPHFAAAYRERAILFFRFNQLDKAIADLNRAISLGLRKADTYCDLGSLYLEKKQYDAAQLNCQKAIELDVTHVRSYYTMGLVHQRLKKYTKAVKYYSKSIELEPQIFSYLNRGNVYRDLEQYSKAVDDYIKAISIKSYYPAHANLAAVYNIIGLYEKAIEQATVAIRLQSKYEEYYQRGLAYHKLRMYNKSIKDYDKAIELGSALPAVSKVYDKRGDVYFAIGDHRRAIDNWQKVVALIPATRPEMVKKIAKARQRRK
>NZ_AP019860.1|WP_151969184.1|4649856_4650069_+|MbtH-family-NRPS-accessory-protein
MSEYKDWQDGELKVVVNHEEQYSIWPADREAPEGWREVGVRGDKATCLEYIEKHWTDMRPLSLRKQMDGG
>NZ_AP019860.1|WP_151969185.1|4650156_4650735_-|PEP-CTERM-sorting-domain-containing-protein
MKKLIALLAMSFICVSLYAESFTIGNTQPGTFFFIQGQSFTPNVQGNEGTGIATPNPDGNILLTSFSLDFVNAATAPGEIHIFASAPTLAQAASGTGSIGTGTHVGGGVYDFGPGLLIPFFAKSFAVLPNSAEIFDAPNAYAGGADLFPIGGFVNEGGFDAGFNATFQTVPEPSTYLMFLILGACVITRRKR
>NZ_AP019860.1|WP_151969186.1|4650949_4653403_-|hypothetical-protein
MRILLCSILLANHLLLALSTNEAKTLISQAASFSSEDMTSAKQKPLSLLLLNLNLHLEKQINPDVVKDFSYFKIENIDRQEMLAAIRHERQNTYSFVYPQHIVKCEFKLDGNVASGQFTFEIKDLYRGTALFNAQRHDEKWRITSFTLPNYGLRVYHEQKKWQTACLPTRFVIVRFAQNAIYTSNWFESDMDNEQKICDLDNLKNCETWLKNFAQKSTRQKISQMKMVIHASKALWDKVKGFIALVAKHNIYKLYFTHDRKTIVQNYLPMDVGVSSSNHQTRPKIIIMVNNNVFSIGKNSFSGQENYKLLTAHLQSLLKPLSSSEIAFEIRASNETPYGNIVRILDLCRNTADGMQKTSVIKFSLYAPTTSDVEVHEEAIGIIEKIPIEKSKAVVEDPVIEDPVIEDPVLKEVEEDHYETFDESYAHDRLSDRPFGDNPFGGNSRIDAIGVGGGAGSFGALGSFGPHFGGKLPRITDDQRVKEIEEAICAGLTWLKNHQQADGSWKAATFSDFCKTTPCRGFGTEEMDTKVTALALLCLVNSEERTFAKLKLKRHARSAARYLCRLQSDEGCFDQKGYDYMHHHAIATLALCKLYQKIYSPVLRICIQKAVDFMIKAQNAESGWGHTSQSGRSNTSVTSWCVIALTEAAKTDFVVPRDFYSGVKKWLSATTDEHYSRTGYMQKGDTGPRLQNAPNFLPVETMTAAAICIRTALGMSRSENNNSAVLVESNLPTWKENDNRKSTIDYCYWFYGTVAMRHMKGDFWQKWRKALLPILLEKQCPNDCKKGSWPAIDAWSKAGGRVQATAFNTLSLQMFYR
>NZ_AP019860.1|WP_151969187.1|4653673_4654783_+|efflux-RND-transporter-periplasmic-adaptor-subunit
MRIIVRIILRILEAIVVFALCCLCFFAAKPDYFTTEEQKKVKRTSETPPVRVVTRSVQFLANDRVFQATGTSIARKSVWIYSPVAAQVTSVNFTAQKRVKKGALLLQLDDREERLALQLAKVELQNAEKVLTRYRRTIGGRAVSANEIDAARLGFDAAKVRLEQAKFAVSERKIIAPFTGVVGISRVDLGDRIATNTIITSLDDRSGIYVDFQVPELLAGSLSPNLKAEMTTPAFPGKTFIGTITDVESRFDVQTRTVRIRVSIDNSNDMLRPGMSFAIKLHLKGKIFPAVPEISLKWGREGAYVWLIKNSKAQKTTARVVARTNQQVLVDAQIEEGDIVVIEGTQRLREGREVVNDSEKEQEYNGPTR
>NZ_AP019860.1|WP_151969188.1|4654766_4657871_+|efflux-RND-transporter-permease-subunit
MDRQGKNFSALVVRRPVLIIVINLLIIIAGGAAMFGIDIRELPNVDRPTVSVRAFYDGASPETMDAEVTRVIEGAIARVNGVRNIRSSSEENNCRIRIEFQPGVDLTDAANDIREAINRNRRQLPEDVEEVFVVKADDDAEPIIQLSAVSNTLSKDELAQKIEKDIMPAFLSIQGVAEVRLSGNQKRELRVLLKPTQMAKLKINVSLVENVLRNARLDIPAGSYKSGDQELLVRANASMSTPQQIRKLILRDNVYLEDIAVVFFAPEEAESYARLNGSIVIGLDVVRQAGANTINISKDVDKQVDKINRRNRDVEIIKTADDAIFIEGAIKEVLVSLLFSVGIVILVIVLFIGSVRATLVPAVAIPISLIGTFSAIWLMGLSINLLTLLALVLATGLIVDDAIVVLENIQRHQKNGVKSMAAAVIGSQQVFFAVIATTVTLVSVFLPITFLPSQAGKLFREFGLVLSVSVIISSIVALTLCPMMASRLTIAEAEKTWFPMTKGILNFCGQIFSHFYRFSLKICIKFPVICLLSILVLCCGSWPVFQSLKQELVPKEDRGSVRIMLTGPDGASLPYSDRQAEKLEAIMYPYYKQGIITNIYTTVGQYDKNRSSIVATLKHWEERDINQLELTKEIQERLGEIPGAQARVRGGNSLGVRGGRGGLNIALLGNNYSEISAAADALVLAVESLPEVTDTRADFDTSQPELAFTINRRKTNDLGVDIVDIARTLRAMVDGYEVARLNIDDEEVPIILGSVDGAADDPEDLLNVFMVNDQQNLIPLLSFVDIKESGIAAELDRHKQRRAIEVDIGLKPDAVLSEVVREVEKIGEEILPSGVNILLLGDAADLGETSYELSITFGLAILIVFLVLAAQFESIGSAFIVIFTVPFGLSAAVYALYFTGQSINLYSQIGLVMLVGLMTKNSILFVEFMDQLREEGAEVKEAILRGAQIRLRPVMMTVLSTVVGSLPLVLSSGPGSEARSAIGWVIFGGLGLATFLTLYLTPIGYALIAPFVKPRSHAQKILETQLQEVQKIAS

Crispr_ID: NZ_AP019860_22

• CRISPR_ID: NZ_AP019860_22
• CRISPR_location: 4853234-4853345
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_22

Consensus_repeat	Method
TGTACCTGCTTATTCGATGGTGAGGGCATCGCACACCAAC	CRISPRCasFinder

spacers of NZ_AP019860_22

>22.1|4853274|32|NZ_AP019860|CRISPRCasFinder
GAATATCAACACATTATTTCCCTTGAACAACG

CRISPR arrays and Neighbor proteins around NZ_AP019860_22

CRISPR arrays

The CRISPR arrays of NZ_AP019860_22

>merge|NZ_AP019860|22|4853234-4853345|CRISPRCasFinder
TGTACCTGCTTATTCGATGGTGAGGGCATCGCACACCAACGAATATCAACACATTATTTCCCTTGAACAACGTGTACCTGCTTATTCGATGGTGAGGGCATCGCATACCAAC

>NZ_AP019860|22|18|4853234-4853345|CRISPRCasFinder
TGTACCTGCTTATTCGATGGTGAGGGCATCGCACACCAAC	GAATATCAACACATTATTTCCCTTGAACAACG
TGTACCTGCTTATTCGATGGTGAGGGCATCGCATACCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151969327.1|4844358_4845441_+|PDZ-domain-containing-protein	unknown	unknown	gnl|CDD|238487
NZ_AP019860.1|WP_151969323.1|4837354_4838140_-|signal-peptidase-II	unknown	unknown	gnl|CDD|376504
NZ_AP019860.1|WP_151969334.1|4854621_4856982_-|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|223650
NZ_AP019860.1|WP_151969338.1|4858931_4860308_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969331.1|4847826_4848717_+|hypothetical-protein	unknown	unknown	gnl|CDD|238487
NZ_AP019860.1|WP_151969326.1|4842393_4843893_+|YifB-family-Mg-chelatase-like-AAA-ATPase	unknown	unknown	gnl|CDD|223679
NZ_AP019860.1|WP_151969339.1|4860317_4862855_+|hypothetical-protein	unknown	unknown	gnl|CDD|129694
NZ_AP019860.1|WP_151969333.1|4853356_4854538_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|273776
NZ_AP019860.1|WP_151969329.1|4846219_4846765_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969324.1|4838162_4839449_-|hypothetical-protein	unknown	unknown	gnl|CDD|234856
NZ_AP019860.1|WP_151969342.1|4864650_4865517_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969340.1|4863096_4863942_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|366133
NZ_AP019860.1|WP_151969332.1|4848799_4852744_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969330.1|4846783_4847779_+|trypsin-like-peptidase-domain-containing-protein	unknown	unknown	gnl|CDD|273938
NZ_AP019860.1|WP_151969335.1|4856975_4857677_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213222
NZ_AP019860.1|WP_151969336.1|4857842_4858400_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969341.1|4863955_4864588_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969328.1|4845619_4846186_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236608
NZ_AP019860.1|WP_151969337.1|4858401_4858734_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969325.1|4839841_4842316_+|protein-kinase	unknown	unknown	gnl|CDD|270916

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151969327.1|4844358_4845441_+|PDZ-domain-containing-protein	gnl|CDD|238487	cd00987, PDZ_serine_protease, PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of protease-associated PDZ domains a C-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in Eumetazoan signaling proteins.	2.16767e-20
NZ_AP019860.1|WP_151969323.1|4837354_4838140_-|signal-peptidase-II	gnl|CDD|376504	pfam01252, Peptidase_A8, Signal peptidase (SPase) II.	8.00355e-32
NZ_AP019860.1|WP_151969334.1|4854621_4856982_-|FtsX-like-permease-family-protein	gnl|CDD|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	1.09743e-09
NZ_AP019860.1|WP_151969331.1|4847826_4848717_+|hypothetical-protein	gnl|CDD|238487	cd00987, PDZ_serine_protease, PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of protease-associated PDZ domains a C-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in Eumetazoan signaling proteins.	5.71833e-14
NZ_AP019860.1|WP_151969326.1|4842393_4843893_+|YifB-family-Mg-chelatase-like-AAA-ATPase	gnl|CDD|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	0
NZ_AP019860.1|WP_151969339.1|4860317_4862855_+|hypothetical-protein	gnl|CDD|129694	TIGR00606, RAD50_homologue_ceRAD50, rad50. All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).	3.09394e-08
NZ_AP019860.1|WP_151969324.1|4838162_4839449_-|hypothetical-protein	gnl|CDD|234856	PRK00885, PRK00885, phosphoribosylamine--glycine ligase; Provisional.	9.86955e-91
NZ_AP019860.1|WP_151969340.1|4863096_4863942_+|FHA-domain-containing-protein	gnl|CDD|366133	pfam00498, FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.	1.16647e-18
NZ_AP019860.1|WP_151969333.1|4853356_4854538_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit	gnl|CDD|273776	TIGR01730, COG0845:_Membrane-fusion_protein, RND family efflux transporter, MFP subunit. This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate].	3.27046e-21
NZ_AP019860.1|WP_151969330.1|4846783_4847779_+|trypsin-like-peptidase-domain-containing-protein	gnl|CDD|273938	TIGR02037, Probable_periplasmic_serine_protease_do/HhoA-like, periplasmic serine protease, Do/DeqQ family. This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides].	2.03336e-51
NZ_AP019860.1|WP_151969335.1|4856975_4857677_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.29188e-104
NZ_AP019860.1|WP_151969328.1|4845619_4846186_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	6.08241e-43
NZ_AP019860.1|WP_151969325.1|4839841_4842316_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.25176e-101

Protein sequences

>NZ_AP019860.1|WP_151969332.1|4848799_4852744_+|hypothetical-protein
MNELIKFYYRAVSYYYVGNNYAFAQEECYKAIDFSTHNKVATALLKVLKPRAHTRFNSFHCHKLLEQLDNADIDNFLVLFLAQYHAESIVFRQINWGPLQENFTPNAVKHRMWAHIFEGDWRYALQSAESLLLPIQGDPVVYFQLATIYFHMRHFSEAEKYLFVLGQYGGIYTTAAISLLLQLPQRTFDTLAKNVLLTKYSQTLSMSEKLVIADFLQKSWDQKALFAYGKSLLKQAQDRKDYLGLAEVYLEAGYWNQAIDCCYALRKPTGEDIEEITRIFLHHPSQAITKSHKAYKFFKWLIVTSKDSSAVFFMNRSLRSVLPKLAMKGYKKFRSENEKESLLGQSICYFYLCKYSRCKKLLCHVEEKYPDLSAQVTEWRARIDVQVKPQQTLLELWGKSDKLDVERVLRDLCSSVCPVCHTYQKELSFCHKCGFIPLNIFAWENDHLRWQSNKLLFPRELLLVTTSAIIYEKNTTVVFVVFSPRSVTFELKKNGKQYDTNTIDVNGLEILKKTLNETGMYEAIVRTKYTESTCKFFVADGNDELSVSCVTQRWVAERELEIVLRVADGWGYGVSGTPQVDLYDLHTQNHRKCNIIEQKGNRLYCYWKNLEVLTPYKYVFLKMGEQSWVITVKTQKTASWQQIVERFYSPLEKVGYQYQVTKKKLCIDTKYSCQEMSVVTQPIGADAVDIFRENNTQYLEVSIPKFVGGAYFGAARFAKKKAQERGVEVAFPLICPPPKFRVSFPEEVQPNLKFSVDVSSDFSGKLYILSRDKNVLFYSLKDQLAMRDNTLHCQHSQSTMWNVLPSDLNINSRYYTYIGDYDFSQSGQIELKAMPQEGTQKFTFLASDGNFFIEKTIAIRVIHSMKIECSFPEKIGEKDHCDIPITFCSQLSVPFSVHSQNKGVIVEGQAGNETVSIKVHEPDVFTLNLGDKKQVHKVDPLLEREETHSVIEKVTPENISADVRVYRNGYGLIREIATNIKDDPFCGLDHVAAKLYALGVLYKLTAEGKIDSDQYQNEQAILQWQKHLPDIENLNFREPQLVTVILLYLSLYIEIPKFKDIKKCATDLQNKCLENNIKDNRLLFLSLDFSKKTRNALDAAGAILHDIKVKKATRYLQKTMKDSSWTSKLLGGNITATVWATHALCRIDHHLAQQAFDYVNTQWGNNSLGNVHADIAYMKLMYAVTQKNEQLSWQRKDTSLLSFVLQGLKPQQLKLRLVGPEVLKPGHEFTLKGRIKSKYPKILLYIPGNIIVYNPQYQDRKHSYSGNVVWPISTNELQLKCKALCSGVGTVYVVVEDMYKYGQKIYDSYQLVVV
>NZ_AP019860.1|WP_151969331.1|4847826_4848717_+|hypothetical-protein
MKYWVMIFSLLITSMTFAQSEKEITDLIAKLGSDEFKVREEATEKLTEIGQTALPLLREAENHQDPEVSWRATKIIKRITEKQLQQENIVKKEERQRKQSTPFAKEFEYKGPGFRFKFRFSGNVDDLFDVEKFLKDGDIPEFLKRRQFKHVPKDFIRDIEDFQRQWEDFFSEDNGRDIDRLRRQWQKMLPFNRKRQTPQLKNNSFIFGLQLQKVDEVVRAQLQLKENQGVLVKNISSRGRFANAGFQKWDLILKVNEEVIVSPQQFKEIVDNLDDKAKNTVAIVRRGKPQVIEFVK
>NZ_AP019860.1|WP_151969330.1|4846783_4847779_+|trypsin-like-peptidase-domain-containing-protein
MPVHKNIHIYLCLLFSISSIFCQTDNTTKAPSLLDIENAVKHIVDKVKGSVVSVESCNSENKFSRHSGVVLDDLGHVVTIASSIRGAEKVCIKTLSGKLFPAKLVGIDNVTNLALVRVEDAQSFPCVVKGDSSKLSLGSFLISVGNPYGLQNSPSLGIVSGLERVVKFNDHLLLGLIQTTAAINPGDAGGLAVDSKGEFVGVICSTLGASKPMGNAMVLPQGINFVIPSNTVYWVCENLIKHGKKRGRMGINVKDQPQGGVVVTKVGAETPAAKVGLETGDSLLEINGVPIQSARKLVGRMYHMLAGDTIEFKVKKKDEQVVTVKITLESS
>NZ_AP019860.1|WP_151969329.1|4846219_4846765_+|hypothetical-protein
MFQWFIRKFIPLSLTKDELPIFGKSLQHRISKSYKQEQNKYEFHRGNLQLLGSTKLKEENFDDYWRDIKSKMKEQKSSNLAINVPKVTYPNLYLRRGFAIACALIFIVAIVGPFNMDKSNSIFSANVSFTSIIFGVPNQDSNSQDGLLPADLYVEDMQIDLQKQTYELDRVVNCKLESAAF
>NZ_AP019860.1|WP_151969328.1|4845619_4846186_+|sigma-70-family-RNA-polymerase-sigma-factor
MADKEDTDIIKRCQQGDEEAFKQLVKRYQDKAIWIAYQMVNNYEEARDISQDAFIRVYKSINKFNLMSNFYTWLYRIVVNLCIDHLRRFKNRNRAISTEDIGEICDEKPSHEVNLEKMELLQKIYNVLEQIPPKYKAILILRDIEDYDCKEVADILNCNHNTIRWRLFRGRQIFKDIWEKTEGSKSPV
>NZ_AP019860.1|WP_151969327.1|4844358_4845441_+|PDZ-domain-containing-protein
MYRMYVLFIFLFGVVFCQEDASLDKVKEELRREMITEIDKKLKDVREELINQVDRRLAGLRQEGYLGASLKEISEGLRTLLDLEPNEGVLVTEVEMDGPAAKAGIEKMDIILSIAGNKVSSPAQLQKLIRSMKPGFTVRFSILSKREKKDVDVKLGGKLYGEKRANPLRKMFSGNSDLEKLMEKQMEQMFGHLPKEQREMMKQMQNKLRKQLENLQKDPESMRELGKNLQDMLKDLVPNENNDETEEDDSDEDAEIDNLLDDLMENDTAVELGMLLIPIPEPLKQREGYEKDYGALVSQVDGLASKKGVQKWDILMEINGQKVTSSNYGNKIISQLKSGSKLKLKLFRKGQEKDLVIDLK
>NZ_AP019860.1|WP_151969326.1|4842393_4843893_+|YifB-family-Mg-chelatase-like-AAA-ATPase
MLSKLWSMTVVGVDGILIEIEIDISNKLPRFDIVGLPDTAIREAKYRVRTAINNSGFEFPYARILINLAPANIKKQGPRYDLPIALGLLMASGQMDNTPFHDTVIIGELALDGSVRAVPGILSMALAAQSYGLKKFVCAKDNAAEAAVVNNIDVYPIHSLRSIDNIFREKYIKTATKNEDKKYHFDYNEVVGQEMVKRAVLIAAAGQHHFLLCGSPGCGKSMIAKRFATILPTLSESESIESTQVYSVAGLANGLVKKPPFRAPHHNISSVALVGGGSFPQPGEISLAHNGVLFLDELPEFSRKTLDMLRQPLEDGGVTISRAQYKVLFPCKFTLVAAMNPCPCGYYGDEHRMCNCPEYMVQRYQKRISGPLLDRFDLHINVRRVEQQFLIQSQTSTSSSEMRRLVIEARTRQEKRFATHNIKTNAQMSLNLIKKFCKLCEESESLIKKANESSGFSARSYQKILKISRTIADLDQSEVVRRKHVAEALQYRFLDTSPF
>NZ_AP019860.1|WP_151969325.1|4839841_4842316_+|protein-kinase
MDVTQNQSIVQRYKILKEIGQGGMGRVYKAYDKNLDTEVAIKVLLAGESANDKQKTRFLREAQALLALRHKNIIHIYDVFSQPQLFFTMEYVDGCTLREYQQQHSRKQTIDVLMKVARAVHYMHENGIIHRDLKPSNILVTKEGEPVVMDFGLAKMMDSSGTLTKTGDVMGTVKYASPEQIFGKPVDKTTDIYSLGVILYEIVYKRNLFEAKSHENLLFAILNDKPEFTGNVSGELQRICKKALAKNKEQRYENAAQFARDLRNFQNGMRTRSRSKQGGSLHIVGIVVAAVVFIFALLGIFLQQSTEEIPYEKTTNSATKEAQQHFARYLDSYEKYELEEAWQHLKNAIAQNPRPAYYVHAWHLNSCFIRYGWDDPIIKLKRKLIQKEFSSILTAEFFARLQSSEDFLDIYSLALIKQMKKSATRAELIAEFEKCWKKSSYSQAAERLLGLYYHEKGFDYAQRFFLSIKKKSPSLYEKHAYLCKLEKRDSYRSYLTAANKGHLDAKCSVAAMDKTSFEPIANEGYARAIRAVCQSHLAKRSADAEKWLKRLQNKQQQLLAYSLYDLEGFIEKGLDKNKLKAQHHFDNFRMLFDCFYVDLAWCEIREAIRLDPDNFVYYIYASQLYMTVLYFVYEKPDDKNEARQKEIADTLRIVKNMVPENPQTAEEKSAKAVYLWYLQKKTLGGKLFEEAYEKHGCQDFFPNLLSYYIEFGKHEKAFRLSKKVMYSDDSTSRAVLACGRVFNGNERVAAYEKSGKLGNINGQCAFYDVRKRQNHRLWLSIALADFYRAFSHLQRIDRRHQYYWSKHAHRKLKDWSGYSVASLR
>NZ_AP019860.1|WP_151969324.1|4838162_4839449_-|hypothetical-protein
MPKNKNLKVLVIGGGILEHSLVWKLKQSPKVAEIYAAPGNEGMRDIAECLNIPETDYFQILKFAKEQKIDLTLVGPYRLIADGIADQFHKEKLRIFAPRAKQAEIGASRVVAKELMRHYSIPTSPYHVFENIDGVMNFCEHAQFPLVLKIEGTALAGTVVCHSMEHVVSHLDKVMKQKVFGEAGERVIIENFIHGDIISMTILIDRQTIIPFPACQIVREFVDGNRYPIKLGAFSPVNCASPRMIHHIEREVIVPLVHAINRQYHSYKGFLTVDMVITEKGARVLDFKIQWSDILAQVLLNVYQGDFVDLILHTLNGTLENLNIQWSKHSVVGLVAAKENQIKSAGGHVKLPIFPMDEEDENTKVFCGKTKRMRDTVWGTGERILGIVSTGKTVNGTYKNMQESVAYNDLKEDIVFRIPQITNKNKNK
>NZ_AP019860.1|WP_151969323.1|4837354_4838140_-|signal-peptidase-II
MKTKDIIIFFAIVITLFVVDIASKKYVFDYFSVVIADAAPQDKDMRILYDDQKPYVYVKKDYEPLEILHAYKKFTIDMKYKSELYHRRVSPTLKKIFKEQGYEIKDRAFIQRAKDMWIVKDWQNGKRFFVKPQEDKLHVSSSFFSFLIVMNRGAIWGILQGQTIVLTIFSLVAICFILFIVFRNDKSKPYMIPLAFITSGAFGNLWDRTFFNGVRDFLDFNLGFMQWPTFNFADVFIVTGVILYCLIELYISYKEKHRKDA
>NZ_AP019860.1|WP_151969333.1|4853356_4854538_-|HlyD-family-efflux-transporter-periplasmic-adaptor-subunit
MQVFKRIVYLIFIGSFIFLIIFAFLPKPVIVEAVAVTRGKLQVTINEDGKTRIKERYIVSAPVAGKQQRIQLNIGDSVIAGKTLLTTIEPSESPLLDERTQTEKVARVKAAQSNCKQCEAQLNRISGELQLAKSERERAQKLFKSQLFSRQDLDKAITTEHTLQQEHKRIEFAQEIARFELEMAKAALEVPEESKSKPRTLNIVSPVTGKILDIFEKNAIVVAPGTKILEIGNMKNLEIISDVLSSDAVKIRPGNAVVIEHWGGKPIRGVVKYVEPSAFTKVSALGVEEQRVNVVINFSAPHGLGDNYRVETRIVIWQNKNVLKIPINTLFRVKDKWAVFVINDNTAQMKIVTIDHWGEFFVEVKSGVKEGELVIVHPGDQIENDVEVVVQGK
>NZ_AP019860.1|WP_151969334.1|4854621_4856982_-|FtsX-like-permease-family-protein
MVIRSLDKKLLRDMAKMKWQCVAISLVLACGIAMFVMSISTRKSLIQTQKIYYDNYGFAHIFSNVKRAPLSLQKRIAKIPGIVKVQSEIVVDVTLDFAEAKEPCIGRFITIGNGPHRKLYLRKGRFVNPNSNSEVMISESFFNARNFKLGDHVVALFNGHKKKLKIVGVVLCPEYILEIRPGDLFPDQKHFGVFWIKYNELAAAFDMQGAFNTINIYLMKNSSTKKVITMVDRLLKPYGGSGAYDRSEQISNRYVSEEINQLANMAKVAPTIFLLVSIFLLYVVFTRLISAQREQIAILKAFGYRHREVGIHYFKFACLITIPGLIFGTFLGVMLGRNLTRMYTKFYHFPIFHFSLDVEVIIYAILISLFTAFFGVFRVVRRAIKLPAAEAMRPEPPPIYKPTFFERAGLSKFLSQRERMVMRHLERNLGKSCFASLGIAMSVSILVLSGFMSDAISYVIETEFHLAKRHDISLIFNEPTSHFVKNSVAKLPGVLYQESFRSVATHLHAKHRSRRLAIMGLQQNSRLYYLLDMHRKRIHLPTKGLLVSKMLAELMQLRVGDFVTIEVLSGQRPICQVQICGIINDFSGLNAYMEKNALHHLLREGSCASGIFATIDSSRKAQLYTKVKSLPHVASVSIKSSLVENFKKTLAENLLVMKMMNVIFAVIIAFGVVYNTVRISLAEKSRDFATLRVLGFTHSEVSGILLGELAVVTLVALPIGIAIGYALVMLSVVGLASEIFRVPPIIYGSTYAFAIIIVITATIISGFFVRKKLYKLDLISVLKTRE
>NZ_AP019860.1|WP_151969335.1|4856975_4857677_-|ATP-binding-cassette-domain-containing-protein
MIVFKAQGVTKVYHMGEVQVHALRGVDLELHHGEFVVLLGPSGSGKSTLLNILGGLDVPSNGSITYAQKTLTDYDDASLTLYRRENVGFVFQFYNLIPSLTARENVALITEIANDAMSPEEALDIVGLADRMNHFPSQLSGGEQQRVAIARAIAKKPNVLLCDEPTGALDVKTGSLVLDVIEHVNKTLGTTTVVITHNAVISEMADRVIYISDGEIAKIEKNHIKKTAKDLVW
>NZ_AP019860.1|WP_151969336.1|4857842_4858400_-|hypothetical-protein
MEKQDPIIVIKEKTLREKHSRKWLYIATISLLVLIIGASGFSYTKNSGKTLVVTITWKKKQTVYHLSSSTTHTLPFFIPKDEYNKVVLQVENSSWHTSQVFTKNPINFHIEGKSIQAQLLNVVSDIPISHQQLDKLARKVKQGIASNDEKILFAKMFSQLYGTIKEKTISGTILSVKIGKNFRQD
>NZ_AP019860.1|WP_151969337.1|4858401_4858734_-|hypothetical-protein
MQANEKKHECGLCKSWIVFTEQRCTNPNCPHYATPKKVNTLPSPLGQLTDDEVSLLYSFLLHDGNLTSTAKLLETTKYHVKERIKKLKAKIEVLASERTILDNYISKSDS
>NZ_AP019860.1|WP_151969338.1|4858931_4860308_+|hypothetical-protein
MSILLLLVCLSLLCAQEENVVVDAKSLANIVMEVNELKENNKKLSREVSFLKERVLGTRKPFSVLQNGRYIIPLIVRTPKIATHGEIDPLKIKQLRDKIAVNLRGAKIITQGELQQSKFITQLLADYTKKLPYRFWYVQFSFSLLRRDYEEMPFHAKLYTKNSADFTPYYLATKNGGNWLGYNDRHRITKAEAHNKFSMRKFNTINACLFTDFSYDVKTQYRYISLFYKNNGEEVALKSPFSSYGFPVTNAKVHPQSVIFLELEKNSPRLWGYLEKLEDISIGPCIIFPKEYEQLQKKQLCFAVDRHRSKIDDIDYDYTFEADNIMIAKDDVSVEENFGYLLCRVWVPNDTKIFTVRMGYLYKKFNCNDVFPGSHLRDIKRVSLPTLQKHIAQFSDPEKKSTCLVKALGTSKPSRKVDIGMIDEIKDFVSHLKTWKNARSTRVSNIIEKFTHIINKAK
>NZ_AP019860.1|WP_151969339.1|4860317_4862855_+|hypothetical-protein
MRNLLIVSLSLFFIGQVMAKDFSRSDKKKIDKAFVGAKLAEEGKTGADFKKGYKTVKSALKSLKRKYADHPQVLELEKRFVELEKLVPHENARADLEKSLKKMKNNLKKVAGGVASAKKKLQKDTTAVQTSMVHLKMTKNARFANNISVAEKALAEAKEHGVELRSEEQVIEEIKLEQSMLNLTRSQLSAIKKIEKAIAKAEKKDEFAQIKKEMDNARKLLEPLSEALADNLKVKSLQERCDNLEDKLASSKVAFDLRGDLKKLDANLKSAEKAKDFDKIDRAVSSAKSILAKIGQKDLTDNEEIEKQIDAYKERVEGLEDKYNSLKLVSETKDDMKKLSYKIPFAEKSFDYRKVKSSMEEAKPVLTKLNNKDNLQDNEEIAAAVKDYTQRFAKLEEKIVFCKKQYDLSEEVEQLDRDMRDLFRAVERALEQKQLPITASSDKYQIMGNAKAFKEAIVLTPQHRKKYSEQMAHVKKEMEILQKRNGEAFSRTIGESRELVDAWQHAMDSEKPLFDHGMMQAKQLEAEQQKGMQALYTKIGSFKVYPKEHLKELETFLTETSTNVWSYMSPFNEHKDFSALVKKSNTCHENGKKYFELIRATKYIHSSLGSGDLGIAKYRFKEVRNTQHEESKKIIAFYDNYLKRWEAAKKDLNKIYSTMLGRLAKSSGSLNSGFEKFRGKFTIIPANRLLIIKDLNANAGKAIKDMTRESLSYSTAWKLNHGNDLFYYALDPALAQRAAVFYQQLKEKFNGYRLQVAKKHTVEERGLPYWRSPGYLHMDMVAVVDTTVNHTPRIAIKDQTGTIKGYVDGTTIQIVKVRVVGYRSKYFTMWQNSPQQQADVSGLYR
>NZ_AP019860.1|WP_151969340.1|4863096_4863942_+|FHA-domain-containing-protein
MEFKTFDELPELPDEHTPQDDTPRPILEEVRSLRKHVIPRYPMFIGRDRQAYVCVPVSAVSRKHAKVFEKEGVFYIQDLGSINGTYVNGKRVLDPVPLKPGDRIKISVTKQYKNGAKEFEFKHDLSQQEELQKDREMLLEDVQIFADDESSSGNVLIKDCLFYVSKKDIVSVIKAEPPRRIAVSQISFRKAKVSFHSLCPYKVKDQLILSVEHPQLPKNMKAQLRVVETEEQEHYGITTHHCEMLKLSDDDKRAFRDKIDASPLICYISSKTIENALETDS
>NZ_AP019860.1|WP_151969341.1|4863955_4864588_+|hypothetical-protein
MSFNAAIHSFRVVHKKMDANHYFASKENRKELVAEIKKAVKWETGKDYICDEDSKKCAAFLTIERNNFLNDIQEYAAGQENRNLEAVYMGKQQSCYSHLIEIQNSIGIFLPIFFFFPLHISTKSHALPIFIGSSIKLHSELTRLNKQLKAKENTVLDEEITPFLEATEEDVEDYEFQHDGVDTFWPCFNYLVLSMLAKRSVATKSPIFIF
>NZ_AP019860.1|WP_151969342.1|4864650_4865517_-|hypothetical-protein
MNKITLIIALLLTMCFADEKQNDFIVEHSSAMIDHVQKDLHDYINGGNYPQVASYVSLPATYADFRGEKSIDNYLNAYFTESEQYFYSLSKKQAQNDRYLESLLLSNKKILVFLNISQFWQQNIGNIVNVSARDKNIDLRGVVVTGFDRDARYFIVKDGAKTIMASYDYIKQNAQSGFYHQQSKQSPQLRNVNFELTRWAFGKGNLFKPKARVYGKAVGHPAFIKWVRMVVEYSGKKRVVLKQQTTAPDADFMLRDTYYRLGSRYGILECMNDDLEVTRFIKRPVDSK

Crispr_ID: NZ_AP019860_23

• CRISPR_ID: NZ_AP019860_23
• CRISPR_location: 5664723-5664825
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_23

Consensus_repeat	Method
TTGGTGCCCTTACCATCGAATTTAA	CRISPRCasFinder

spacers of NZ_AP019860_23

>23.1|5664748|53|NZ_AP019860|CRISPRCasFinder
AGTTTTAGCTTCGCTGTGTGAGGTCTATTCCAGAAAAGAGTATCGTTTTCAGG

CRISPR arrays and Neighbor proteins around NZ_AP019860_23

CRISPR arrays

The CRISPR arrays of NZ_AP019860_23

>merge|NZ_AP019860|23|5664723-5664825|CRISPRCasFinder
TTGGTGCCCTTACCATCGAATTTAAAGTTTTAGCTTCGCTGTGTGAGGTCTATTCCAGAAAAGAGTATCGTTTTCAGGTTGGTGCCCTCACCATCGAATTTAA

>NZ_AP019860|23|19|5664723-5664825|CRISPRCasFinder
TTGGTGCCCTTACCATCGAATTTAA	AGTTTTAGCTTCGCTGTGTGAGGTCTATTCCAGAAAAGAGTATCGTTTTCAGG
TTGGTGCCCTCACCATCGAATTTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151969895.1|5669674_5671642_+|BatA-domain-containing-protein	unknown	unknown	gnl|CDD|377873
NZ_AP019860.1|WP_151969888.1|5661748_5662417_-|dual-specificity-protein-phosphatase-family-protein	unknown	unknown	gnl|CDD|183473
NZ_AP019860.1|WP_151969891.1|5664928_5666128_-|hypothetical-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_173013456.1|5654651_5657069_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969898.1|5673931_5674792_-|DUF4438-domain-containing-protein	unknown	unknown	gnl|CDD|379630
NZ_AP019860.1|WP_173013457.1|5657149_5659828_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969890.1|5663624_5664692_+|Cj0069-family-protein	unknown	unknown	gnl|CDD|223267
NZ_AP019860.1|WP_151969883.1|5653115_5654609_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969881.1|5650583_5651795_-|TIR-domain-containing-protein	unknown	unknown	gnl|CDD|379328
NZ_AP019860.1|WP_151969882.1|5651807_5653004_-|TIR-domain-containing-protein	unknown	unknown	gnl|CDD|379328
NZ_AP019860.1|WP_151969892.1|5666130_5666991_-|EamA-family-transporter	unknown	unknown	gnl|CDD|223769
NZ_AP019860.1|WP_151969889.1|5662519_5663350_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013459.1|5660810_5661671_+|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl|CDD|224182
NZ_AP019860.1|WP_151969894.1|5668046_5669558_+|hypothetical-protein	unknown	unknown	gnl|CDD|237258
NZ_AP019860.1|WP_151969899.1|5675120_5677094_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013458.1|5659909_5660785_+|formylglycine-generating-enzyme-family-protein	unknown	unknown	gnl|CDD|224182
NZ_AP019860.1|WP_151969896.1|5671651_5672938_+|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl|CDD|234607
NZ_AP019860.1|WP_173013460.1|5677212_5678232_+|histidinol-phosphate-transaminase	unknown	unknown	gnl|CDD|235064
NZ_AP019860.1|WP_151969893.1|5667074_5667824_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969897.1|5673047_5673830_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|378924

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151969895.1|5669674_5671642_+|BatA-domain-containing-protein	gnl|CDD|377873	pfam07584, BatA, Aerotolerance regulator N-terminal. These proteins share a highly-conserved sequence at their N-terminus. They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains. BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress.	6.48924e-19
NZ_AP019860.1|WP_151969888.1|5661748_5662417_-|dual-specificity-protein-phosphatase-family-protein	gnl|CDD|183473	PRK12361, PRK12361, hypothetical protein; Provisional.	3.69171e-24
NZ_AP019860.1|WP_151969891.1|5664928_5666128_-|hypothetical-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	0.00205493
NZ_AP019860.1|WP_173013456.1|5654651_5657069_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.56657e-100
NZ_AP019860.1|WP_151969898.1|5673931_5674792_-|DUF4438-domain-containing-protein	gnl|CDD|379630	pfam14505, DUF4438, Domain of unknown function (DUF4438).	6.92923e-136
NZ_AP019860.1|WP_173013457.1|5657149_5659828_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.77949e-96
NZ_AP019860.1|WP_151969890.1|5663624_5664692_+|Cj0069-family-protein	gnl|CDD|223267	COG0189, RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis].	1.17138e-08
NZ_AP019860.1|WP_151969881.1|5650583_5651795_-|TIR-domain-containing-protein	gnl|CDD|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	4.91952e-21
NZ_AP019860.1|WP_151969882.1|5651807_5653004_-|TIR-domain-containing-protein	gnl|CDD|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	1.24156e-21
NZ_AP019860.1|WP_151969892.1|5666130_5666991_-|EamA-family-transporter	gnl|CDD|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	3.83703e-16
NZ_AP019860.1|WP_173013459.1|5660810_5661671_+|formylglycine-generating-enzyme-family-protein	gnl|CDD|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	1.8776e-40
NZ_AP019860.1|WP_151969894.1|5668046_5669558_+|hypothetical-protein	gnl|CDD|237258	PRK12903, secA, preprotein translocase subunit SecA; Reviewed.	0.00501323
NZ_AP019860.1|WP_151969899.1|5675120_5677094_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.02201e-104
NZ_AP019860.1|WP_173013458.1|5659909_5660785_+|formylglycine-generating-enzyme-family-protein	gnl|CDD|224182	COG1262, COG1262, Uncharacterized conserved protein [Function unknown].	1.03159e-31
NZ_AP019860.1|WP_151969896.1|5671651_5672938_+|glutamate-1-semialdehyde-2,1-aminomutase	gnl|CDD|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NZ_AP019860.1|WP_173013460.1|5677212_5678232_+|histidinol-phosphate-transaminase	gnl|CDD|235064	PRK02731, PRK02731, histidinol-phosphate aminotransferase; Validated.	2.31736e-105
NZ_AP019860.1|WP_151969897.1|5673047_5673830_+|alpha/beta-fold-hydrolase	gnl|CDD|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	1.39515e-07

Protein sequences

>NZ_AP019860.1|WP_151969890.1|5663624_5664692_+|Cj0069-family-protein
MKKHVVIFEVRGGSDKGAYGYRSDSKPIIDSLNKRGWSAEIIFYSDEARGEIYRYVVDKAGAYISRVNPGNLADETGYFQMLRELVSQNVEALPHPDAMINYGAKNAIEKLKGTDLVPDDVITYYDFEAFKASFPLMLKTGPRVLKQNRGSTGEGIWKVEIAKKVEDDKGNLTLKTKVKLTEAKDNHIEEKYLGDFIDFCVTYLDGPSGLLLDMPFLPRIKEGEIRVFMLRREPVYVVHKKPVETADAFSATLFSGAKYTYENPDQYPTLISKVKTNLNTILEKLGGYDIPLIWTLDFILDNDENGEDKYILGEINASCVGFSTHLDLSEQIADEVIRLMEADCVINPRWPAYTS
>NZ_AP019860.1|WP_151969889.1|5662519_5663350_+|hypothetical-protein
MSKIWSYELDVNPDMALKTIYANTKNDPMQTNIDAFSGKTWLALANPNEENMKKLLRESDAATEFCGYVSEDAFQVGYLPDDAQKRCLFEPYVLGVANAKDFGCSLICELRYQKYGFRYVLYMGFLMAMLFFFRELYTADYFVAGVFGVLFFPIVFYNYFKNRNTVALHEQKLQEFLPDLFKEHLLSKKDLPENTKEDLPDMELTTGVDIRRIVLLTLYFVTGLIFAGAIAIYLVNFFGIPANIKEFVIGPLMLIFLGLYVATTGIFFRKKKNAEK
>NZ_AP019860.1|WP_151969888.1|5661748_5662417_-|dual-specificity-protein-phosphatase-family-protein
MAWGFLTISALLIMYTIVLQGAFVLLWPAASFALVGISYLTTTTKCFGKKENGHLHWISQFILLPYLVCLWSLWHIIRFFQKENPYDTLNNQITIGRRLFFREMPSDTQVVVDLTCEFNEDKRIVANYEYKCFPILDCCPTQQQPLIDFIKDLALCDKKIYIHCAQGHGRTSMITCVLLVFQEKVSSPQQAMEQIQQKRPRANMTRRQWQLVENCCCSIAID
>NZ_AP019860.1|WP_173013459.1|5660810_5661671_+|formylglycine-generating-enzyme-family-protein
MDRKIIKGKSLQEVKPHTKYMACTFYLDYVDGEDLQNTEFDNCSFRGSFRDWGRDEYGLWMAICYKNVRQVMRWIRPGTFMMGSPNTEEYRLGNEQHHQVTLSKGFWLAETVCTQDLWTVVMEKNPSKFQGKSRPVERVSWNDCRMFIGKWNHEVPEWELCLPTEAQWEYACRAGTTTAFSFGETITQNQVHYDAKRTAVVKALLCNDWGLYGMHGNVWEWCEDWYTHHHVTTTNSLRAPDGSERVIRGGGWLNSPNSLRSACRYSCLPNVYNDDIGFRFCLRSKK
>NZ_AP019860.1|WP_173013458.1|5659909_5660785_+|formylglycine-generating-enzyme-family-protein
MEHAIDKKIVKGKSLQEVQPHTKYMACTFYLDYVDGEDLQGTEFDNCSFRGAFRDWGRDTYGLWMAISYKNIRQVMRWIRPGTFIMGSPSTEMSRQADETQHKVIISKGFWLAETACTQELWKAVTGWSGSSFAVDNCPADDVNWDDCQTFINKWNSEMVEWELCFPTEAQWEYACRAGTTTAFSFGDNIAKDQVNYDLKRTAAVKSRPCNDWGLYEMHGNVCEWCEDWYGEYDSTVVMDPVGPSDGTDRVMRGGCCSDSSGNVRSAARYKFWPNENFGEVGFRFCLRSKK
>NZ_AP019860.1|WP_173013457.1|5657149_5659828_-|tetratricopeptide-repeat-protein
MDYRKPQNNASKKPRIANNSEMKRPLPQQFRTSMFANEHDHYQAIRTGEHFGRYIVHGELGRGGMGIVYKAFDQKFQRFVALKVMIEKDRNEIRRFMRESAIMTQLDHPNIVRLYDFGDTPQPYLTMEYIEGFTLEDLIKTKKVPPAFLLEMLIKVCEALSQAHRQKVLHRDIKPSNIMITNQGEPKVMDFGLAKVATDKHQSISMVGGIVGTVLYMSKEQINGHPTHQSDIYSLGATMYEALTYQTVYQGDSFHEICFQVMHNDPIPPRHINPSISPYFEAICLKCIEKKPQRRYQNFKQLVRELHNFKNNKPIMAKKYNSWNFFVSLTRRYKAAFISLFIIMSVLCCSLVLVINYSIDADRARIKAEEQKNQTRNSLNKVMKVLYYSIREYKALQADKKFAQLFSEIFEDVESYGEDQDWDFLKAYMSSQSGDLQQSIQYYNKLLQENPNNSEVYHYRGLMHFNMKQYKKALQDLDRVIQITPKNLDAYNNRGLIYENLKDYTQAIANFDKILQINPNYAIAYENRASVYSKLRKYNKALQDIKKALQLNPNLATAYDKRGLIHHNLRNYSAALRAYSKALLIQPNFADAYHHRGHTYYDLQQFDKALMDYSKVIELNPKFLDIYYNRGAVYYRLRRYQEAIDDYNKVLSMDAHFADAYANRGLVYYDLQEYRKALADYENALQLDPQNPFVYANRGLLYNAINQPQKALTDLNMAIQLNPKLVNVYNTRGIVYRILHQYEKSLSDFNRAIQMQPTLVDAYRNRALLYQEMKDKRKELADWNKVIQLKPDFHKAYINRGNLYNSMQKYQQALRDYSQAIKLGPNDVKGYVNRGLVYCILKQYKNAIRDFDKSIAVSPTWRSHYGLHQCYKVLNDEEKAQYHLQKMQELKK
>NZ_AP019860.1|WP_173013456.1|5654651_5657069_-|tetratricopeptide-repeat-protein
MDHRKQKNNTGKNPHVAYRAETIRPSPTKIPSNMSTNEQENYQVIQTGQHFGRYIIHGELGRGGMGIVYKAFDQKFQRFVALKVMLEKDRNEIKRFMREAAIMTQLDHPNIVRLYDFGDAPQSYLTMEYIDGFTLEDLIRAKKVPPKFLLQVLIKVCEALSHAHRQKVLHRDIKPSNIMMTRQGEPKVMDFGLAKVSTDKSQSMSIPGGFVGTVLYMSREQLDGNPSQQSDIYSLGVTMYEALTYQTPYQGDSFHEICFQIIRNDPIPPRRMNPSISPYFEAVCLKCLDKKPQRRYQNFKQLARELRNLQSNQPIIAKKYTAWNFFVSLAKRYKTTFISLATIISILCCSLVMVIHYSIDADRARVRAEKQSIDADRARVKAEKQKNQIRRSLNKVMSALDRSLQKHKVLQNDKEFAQLFSKIFQDVEEFGEDENWSFLKAYVSSQSGDLQKGMQYYNEQLQTNPQDPKGYNNRGILYCNLKQYKKAVQDFNAAIKINPKNSETYNNRGLAYKELKDYTRAIQDFNTAIAINPKNFEIYYNRGLVYKDIKDYTRAFTDFDKVIKINSQYGKAYENRALVYENFKNYEKALQDANAAIQLRPNSETAYNTRGIIYQALKNYSLALRDYNKALQLKPTFWYAYYCRGDLYRNWQQFDKAFADYSQVIKLNDDYMQAYSNRGNIYYMSQKYQEAISDYSQAIRLEPNFANAYAGRALVYCNLKKYKEAEADFNKALQINPRFFIVYMNRGLVYLSLEKYKPAIKDFQSATAISPNWKSHKGLYQCYQALGKYKKAQYHLRKMQQLKNK
>NZ_AP019860.1|WP_151969883.1|5653115_5654609_-|hypothetical-protein
MKNLPLLIIVGVIVVGGASLFISQSKATQIVDDLFSDKPSGAILRLALLSDHEQLAVTGFLLQRFEDHYHEYTSLRLTLQIRKKNKIKNLEKLQNELWQKELECTGILAIIKKYIETPRRIEYAERFIGLLSDKKYRGIASDILKQLPEKETAAYIYEAYKNGIIRVDAAFYATNSHQVKAKILKRHVDREKFGAKEVVDDLRSSGHHLYLQALPHYTTSEKGKIFAVLRQIPFSEIGPHEATLPALAHTAKPDEIPYILTLLEKAIEGDPQDYSDDIMRTAAILKDKAKPLSKKLQAKIKEILAGDSWDTYSVELAMALLHIVPDDPQAIEVVAGAKSPELLDDLQQVFLKIVDQNKLLTALEKAFKKRKSFANEHFKKLMIEKQSQVYFDHLMANISTPDHPKPYILNSSLWEISKFANKRKEVVAKFITILQSDKYQDSDKRTIVYILGKEMAPNSSSAISIIKELKEKHQDNAQLLMAEFCDYALQNIEEVRK
>NZ_AP019860.1|WP_151969882.1|5651807_5653004_-|TIR-domain-containing-protein
MQLINNIAVYHNSEPRFIELHKGDLSQIPDKDAVDILVVSSFPGDYNEVPGTLIGALSDQGVSVGKLAKDKESDLRDTFSCWLSKEVENKGVNFKKILCFEPRKREQHVPEVIGDIFQSLIAFLSNSESLQDVAMPLVATGSQRASKNEILTALVEAAAHWLGMGLPVKRIKIAIYNQSSVDEAMDVFSQLKEKYHQQAPLKEKSKDDSYQYDIFISYSHQNTAEANHLVSLLKELDDKLRIFIDRKELDVGCAWQQQIYDALDSCRKVVALYSTDYLNSKVCKEEFNIALYRDRDREENVLFPIYLYSAALPTYMKVLQYIDCREGDQNKLRVACKKIISDESSQKLSGVTTTQSSNKDDVYSLIRELQAQMSTTTDKLNDMQHKLDKLYKRVFDSE
>NZ_AP019860.1|WP_151969881.1|5650583_5651795_-|TIR-domain-containing-protein
MKMIDSITVYHNSQPRYIQLFHGDLSEIPKEEDVDILVVSAFPGMYDPSKGTLIAALEDKNVSVGGHALNKAVDLRESFSCWISQEIDQERCPVNFKRLLCFEPLKIRQQIAEVIGDIFQSMIAFLSNDNELKNVAMPLVSTGKRRAKVSQVLTSLVEAAAHWLSMGLPVEHLKITAFTEKDIREADRIFPELKKRYDQFTQPKTASDVSHHKYDIFVSYSHQDSEQANKIVSFLKELDSELQIFIDRRELNVGCAWQQQIYDALDSCRKVIAVYSEDYLNSKVCKEEFNIALYRDRDTEENILFPIYLYSAMLPTYMKVVQYIDCREADSEKLKDACAEIIAELKGSKLRQVRKQITYKDEQRRANSEILALLKNLQTQVDKTNERLLQLEKKVADILKEKS
>NZ_AP019860.1|WP_151969891.1|5664928_5666128_-|hypothetical-protein
MSDTKIPQKIKDLVTEIAASQNVFKRNIVVQLADENAALRYSAVWSVFTESVIDAAPIVIELLHDTNLEVRLAAIAVCGRLQLRMAAAQIQSLAQCARISEKYAAQQALEDIHYDSTTKRFTEIVCDDKNLQQKIQQLSAATTFHERTGKITSLVAHATPETLSLFQQLMQIPYTRLQCEIVKKLAKIPNAQAFLVDLLPQSSPTLRKELCNFYIKHNVNQAIPILIDLLQMENGDKNLLIETLGELNAHEAVTAIYNASNDNVAATALAKIYSENTIVPQFLADSGKEFQQLFLMTTINITRKREVKQEIEEKWLQWEQDPHIDLSSYVEKICGELTVKDIAMNEETCHVQFMTQIEKEIEFTSTSLIAVEGTIAFSVHHKPKVQWQKQETLKSVPLE
>NZ_AP019860.1|WP_151969892.1|5666130_5666991_-|EamA-family-transporter
MTNTENTTPYIFILLLGICGISFAPIFVRYSQINPSAIAFWRVAISAVILGIAFFVIRPKMVTQRKVSLIYLFLPGLFFAGDLTLWHWSIKMTSVANATLFANFACIFVTFVSWKWFNERITWKFVLGAACAVTGVIILLGVNIGNSTNLRGDILGLLTAIFYASYILSIKKLREYCGALQIMFVSSAACTLCLLPTLLQPNSIPTDVREWSILIGLALVSHSLGQGLIAYALAKLAASFSSVSLLLQPTLAAIWAWILLSEPLSSTQMVGGGIVLIGIYFARKGR
>NZ_AP019860.1|WP_151969893.1|5667074_5667824_-|hypothetical-protein
MKKTITLLFALLFSLTYADENSQQVAYVGTLVKNVPLGMKNPSEYCLEDGYIYKGAAYRIAGMNIHSDQQQDLSPLAGKVVIIYGKVVKDLNKILVKGEKAPEDYGREQSMMQIRSDWVTEETGFSIGRSSKEKLKEFSFIHYSKVEEFTGLQVEENDTTVSVTFRNMFDRDIKDLQITAHYEVVFGKPQPRYTTNQVNYLYKGQSVTLTFPMTFNTQRFKHSKRKRSAKYRDINISAHNDNLRIHITK
>NZ_AP019860.1|WP_151969894.1|5668046_5669558_+|hypothetical-protein
MNTFSDRMTNFAQEVLTRFADELPEETFEHVSDIVLRELQYQQIQEKIYVPLKEFLDALQKNSQTNDKIIKRIDAMLAGNVQQLQRDDKQMSLLQDLKKEQQSFADRVDELNEEVGTTLHNELLSNIKSECSEIVQKISQKMENASVQYNKDNTNISNQIGMLIEIHKTFIEEFKSSDVSQAIEEATTKLENLQKDSLNKVSAHLESIPELIQSEIMEAIDQQEILDSLKEQQNFISNKLEERVEKDTTPSLEESQMLLQPIQDAMLDQSGQLENMLSNIQDSLAELQIQHAEVAEESAAKPQSATAVSSSEDIEDKIKNIFQPLIDKLEDSLLENIRPKDLDTMKKSLSKIMETGFWRIEQLIENNDPGSADSTPQVRKDSGDALKNQLQTIENLLKEKLEGGNTETHSDGILARLKENTQEIVGHVFDDIKTHFMSAEIDNKLSSIDEKLNKMNVIEEKLQKMQDLDVMQEKLDKLQEAISSVDNKVLELATQLDKQESSE
>NZ_AP019860.1|WP_151969895.1|5669674_5671642_+|BatA-domain-containing-protein
MLNNFLLPSALWWLLLIPCVILLYFLKLKRQEYVFSSTLLWQKVVNDMRVNSPFQKLKNNLLLYLQILILLLTILALARPFLSQQALQGRNIVLLIDTSLSMKTKDEDGSSRLAHAKKKALEMMNDLNSDDRMMVITFDSHAEIVQTFTHVKTRLSSSINRIEAVDTHTNIIEALDIAKAMVDKISSPSIYILTDGRIEGFQKHINSYMQNKDPVLPQIVICGQSSSNIAITAFDVQKNQKNDLYQAFVQLQNFGRSNIEVIVELHINGEAKEQNMRLVELGGGDVRGVLLKNLEIPTGVVKAKVVVERGNDYLKEDNEAWFIVPPHLKKKICLVTSGNFILKKVLESHDANMLILSMEEYEEESKKPDSLLRKYDIIVFDKEQPKRIFPGVGNIFFECIPREKEIENNGVLNNEYGFKVVDQNSLHPVMRFLDMRKFHFGSIMDITWPEDTTPLLEVEGHMIIGLIKRQSVYSLVIGCDIYDSGWPFDPTFPVFIANAISWYKGIHNQPNIMTSDIARVQFFESVDHVKITCNGKSIEEQKITANSVRFSDTKKLGVYQFSGFDNEKNLVETRNIAANIFSLDESNVTPIKEFKIKKQNVASRDFLTINREIWPYLLLIAFFVVLGEWYLFHRRSLSFSLRKKDNFFTQYLTNK
>NZ_AP019860.1|WP_151969896.1|5671651_5672938_+|glutamate-1-semialdehyde-2,1-aminomutase
MDQTKSKALFTKACDVIPGGVNSPVRAFKSVGGTPPFISHAKGAHIFDVDGNKYVDFIGSWGPMILGHANDEVLGEIARVMEKGTSFGAPTELEITMAEAIIERVPAVDVVRLVNSGTEATMSAIRLARGVTKRDKCIKFNGCYHGHGDSFLIAAGSGATTLGIPNSPGVTKATAQDTLLANFNDIESVKEVFEKYPEDIACVIVEPIAGNMGCIPPQDNFLQDLRTLCSKYNALLIFDEVMTGFRVARGGANELYGVDPDLLCFGKVIGGGLPIGAYGGKRDLMNHVAPAGPVYQAGTLSGNPVAVTAGLETLKRLTPEVYETLEEIGGYMQSKLHDIITKNGYPLSQTRVGSMVCLFFTPNEVRNFADVQKCDLEKFNLFFHEMLKQGVYLAPSQFEAGFLGICHTKEIIDEVAEKAQKALSVVFS
>NZ_AP019860.1|WP_151969897.1|5673047_5673830_+|alpha/beta-fold-hydrolase
MTLGSLKITKYQKRISRQDNSDFMATVFIPQKKQRYAVVVFAHGFFHDPWRYNSLMKYIASWGYIVVAPHSHNGVWPNHKGYARDLGLCMEYVRKSQQKKDSIFFERYNGKGAIIGHSMGGGAALLAAVDAKPRLVVTYAAAETTPSAKKATQKLTCPAVFVISNNDKVISNSDIHQMYDMSKHEAWKIGIRGAWHCGYEDVSYLGCDSGTLARQQQIDIAKIITVVALKCYVDKVLTRQFLQKAFATDFLEVKHKNNAP
>NZ_AP019860.1|WP_151969898.1|5673931_5674792_-|DUF4438-domain-containing-protein
MLENNAEKLIKISVQGEAQHPYVGSPYRIDKEGRAHIVTATGGIIYNVQMGDSAMGWEADHLEPGVSVKNTEKLYNAALNLYACLGNEAKLMSGEAKGKKGFVIGIHGGVDHVMVHFPEDVLEDMALGDKIRIKGFGLGLKLDNYPDIHVMNIDPSLLMKLGVAEDGEKLKVPVTHVIPPYLMGSGIGTSTATKGDYDIMTTDSEEVEKINLSTLRLGDVVMIKDWSNNYGRAYLKGAVTIGVVIHGDSLKMGHGPGVQVVMTAATDLIEGIITPDANIANYLGIK
>NZ_AP019860.1|WP_151969899.1|5675120_5677094_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MTNDNNAKNQPKESFPTIPNYKIEAEIGRGGMGIVYLGSHEFLKRKAAIKIINDTSSKNENQVQRFLQEASIVAQWKHDNIALVYDMGKNQKGDYYFAMEYLSGETLEELIAQRALSIKRSIDIICDVLRALDYVHNYDPVIIHRDIKPANIMVDEQGCVKLMDFGLAKIEDVGSFTSDSVTLGSPYYMSLEQALSSKTVDARTDIYSTGVVFYEMLTGNVPFKGDSLTSTLLLIARGEYPKPSELNPQIPPELEKICLKAMSLDVETRYQTTAEMLEDLQNFSMPTTRNNSIDTTTGKMASPPPKEENDVKNAETVVDRSVSIDEESVIDMPLPSLSQTQVKRCPQVIENVRKESQKINLPPMEQSVWDVCWKKTYFNFTEEVWVRLPFLKQMEYAQKYQYWYAKKHGLGLTMQENEHATPFVFKLIPPGKFWMGSPKREYRHCDDEILHKVLISDYFWISETPVTQEQWKSIMIYNPSQFKNEKAPVEKVSWNDCKKFFQVLGNKFKLPTEAQWEYACRGGTTAPFNLGFDIKSSKVNFNGHYPYRDSEPQEYREQTISVKTLKNQNSWGCYDFHGSVWEWCNSWYGAYPQKEIINPEGPSSGTKRVLRGGCWDSVAESCRSAKRISSHPHAASSIDGFRIVLNREMNYSIIGDD
>NZ_AP019860.1|WP_173013460.1|5677212_5678232_+|histidinol-phosphate-transaminase
MKIKLDANENPWGPSPQVVEIIQQIATNLHRYPKRDDSELCDALSAKYNLTKQHFCVANSACDVIEMITRAFLCKQTQAIVCPPTFHIYEKMAKLQEAQVLEVALGAKDFSYNITQIIAAITPQTRVVFVCSPNNPTGSTLSSSQFSELLRGIPKDVLLVVDEVYKHFADDNDLKQSMHYTNNYRNLFIIHSFSKAYGLAGMRLGYGVSHPSTMLKIRKFYRTYHLNSLALAAGIAALNDEEHLQKSVAQVKEQRVFVHNELQKLGVQCWPSEGNFILIKPKDSEEMHKYLQQNNIAVGSTAKSGLQGGLRISIGLPEHNHLFLKSMEKYLQRSDGCKK

Crispr_ID: NZ_AP019860_24

• CRISPR_ID: NZ_AP019860_24
• CRISPR_location: 5839077-5839169
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_24

Consensus_repeat	Method
CCGATTTCTTTGGGGAGTTCTGT	CRISPRCasFinder

spacers of NZ_AP019860_24

>24.1|5839100|46|NZ_AP019860|CRISPRCasFinder
TATCTGTGTATAAGAGAGGTACAGACGTCGGAGAGAAGTTAATTGT

CRISPR arrays and Neighbor proteins around NZ_AP019860_24

CRISPR arrays

The CRISPR arrays of NZ_AP019860_24

>merge|NZ_AP019860|24|5839077-5839169|CRISPRCasFinder
CCAATCTCCTTTGGCAGTTCTATTATCTGTGTATAAGAGAGGTACAGACGTCGGAGAGAAGTTAATTGTCCGATTTCTTTTGGTAATTCTGTT

>NZ_AP019860|24|20|5839077-5839169|CRISPRCasFinder
CCAATCTCCTTTGGCAGTTCTAT	TATCTGTGTATAAGAGAGGTACAGACGTCGGAGAGAAGTTAATTGT
CCGATTTCTTTTGGTAATTCTGTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151969986.1|5827314_5827935_-|metallophosphoesterase-family-protein	unknown	unknown	gnl|CDD|277338
NZ_AP019860.1|WP_173013473.1|5846374_5846941_+|hypothetical-protein	unknown	unknown	gnl|CDD|288934
NZ_AP019860.1|WP_151969988.1|5833782_5835756_+|oligopeptide-transporter,-OPT-family	unknown	unknown	gnl|CDD|224216
NZ_AP019860.1|WP_151969996.1|5843257_5844310_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969995.1|5842040_5843030_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969984.1|5825322_5826279_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969987.1|5828106_5833650_+|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|227111
NZ_AP019860.1|WP_151970000.1|5848358_5853134_-|protein-kinase	unknown	unknown	gnl|CDD|238121
NZ_AP019860.1|WP_173013474.1|5847813_5848248_-|hypothetical-protein	unknown	unknown	gnl|CDD|238160
NZ_AP019860.1|WP_151969985.1|5826282_5827266_-|glycosyltransferase	unknown	unknown	gnl|CDD|366154
NZ_AP019860.1|WP_151969989.1|5835856_5838334_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969997.1|5844444_5846262_+|hypothetical-protein	unknown	unknown	gnl|CDD|226098
NZ_AP019860.1|WP_151969990.1|5838350_5838824_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_152022042.1|5847161_5847746_+|heme-binding-protein	unknown	unknown	gnl|CDD|377411
NZ_AP019860.1|WP_151969993.1|5840810_5841701_+|lipoyl-synthase	unknown	unknown	gnl|CDD|235493
NZ_AP019860.1|WP_152022041.1|5822660_5823569_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_AP019860.1|WP_151969982.1|5820769_5822635_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969983.1|5823579_5825199_+|hypothetical-protein	unknown	unknown	gnl|CDD|224196
NZ_AP019860.1|WP_151969992.1|5840056_5840758_+|hypothetical-protein	unknown	unknown	gnl|CDD|319743
NZ_AP019860.1|WP_173013472.1|5841687_5841924_+|hypothetical-protein	unknown	unknown	gnl|CDD|237001

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151969986.1|5827314_5827935_-|metallophosphoesterase-family-protein	gnl|CDD|277338	cd07392, MPP_PAE1087, Pyrobaculum aerophilum PAE1087 and related proteins, metallophosphatase domain. PAE1087 is an uncharacterized Pyrobaculum aerophilum protein with a metallophosphatase domain. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	7.81619e-34
NZ_AP019860.1|WP_173013473.1|5846374_5846941_+|hypothetical-protein	gnl|CDD|288934	pfam12118, SprA-related, SprA-related family. This family of bacterial proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. Proteins in this family are typically between 234 to 465 amino acids in length. Most members are annotated as being SprA-related.	5.23492e-22
NZ_AP019860.1|WP_151969988.1|5833782_5835756_+|oligopeptide-transporter,-OPT-family	gnl|CDD|224216	COG1297, COG1297, Predicted membrane protein [Function unknown].	1.55246e-123
NZ_AP019860.1|WP_151969987.1|5828106_5833650_+|ATP-grasp-domain-containing-protein	gnl|CDD|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	3.27583e-173
NZ_AP019860.1|WP_173013474.1|5847813_5848248_-|hypothetical-protein	gnl|CDD|238160	cd00257, Fascin, Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an internal threefold repeat; the fascin subgroup contains four copies of the domain; Structurally similar to fibroblast growth factor (FGF).	4.02933e-10
NZ_AP019860.1|WP_151969985.1|5826282_5827266_-|glycosyltransferase	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	3.06397e-31
NZ_AP019860.1|WP_151969989.1|5835856_5838334_+|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.37194e-70
NZ_AP019860.1|WP_151969997.1|5844444_5846262_+|hypothetical-protein	gnl|CDD|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	8.9879e-19
NZ_AP019860.1|WP_151970000.1|5848358_5853134_-|protein-kinase	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.96422e-96
NZ_AP019860.1|WP_152022042.1|5847161_5847746_+|heme-binding-protein	gnl|CDD|377411	pfam04832, SOUL, SOUL heme-binding protein. This family represents a group of putative heme-binding proteins. Our family includes archaeal and bacterial homologs.	8.94507e-53
NZ_AP019860.1|WP_151969993.1|5840810_5841701_+|lipoyl-synthase	gnl|CDD|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	0
NZ_AP019860.1|WP_152022041.1|5822660_5823569_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.25689e-90
NZ_AP019860.1|WP_151969983.1|5823579_5825199_+|hypothetical-protein	gnl|CDD|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	3.40276e-06
NZ_AP019860.1|WP_151969992.1|5840056_5840758_+|hypothetical-protein	gnl|CDD|319743	cd16444, LipB, lipoyl/octanoyl transferase. Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.	3.86385e-45
NZ_AP019860.1|WP_173013472.1|5841687_5841924_+|hypothetical-protein	gnl|CDD|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	2.72491e-19

Protein sequences

>NZ_AP019860.1|WP_151969990.1|5838350_5838824_-|hypothetical-protein
MKIYYLIAVCFFVACSSQIRCQFPKENCDALVKNEREHREKLAVEMGDLLKKNTYKKEDICKIVAEIDDMLNIIDANTNINSQWLKSKLASLRDLFPDIATKKTFTTHMKTPLDKCLIVDNCALQKDIYEIVKCHLCILRKTLSSTCDLQTEKCPCS
>NZ_AP019860.1|WP_151969989.1|5835856_5838334_+|tetratricopeptide-repeat-protein
MQILNNRYRFEKVLGQGGMGKVYLCTDINNQQLVAIKECVPKGQRTENTIRRINREYYFMSKIQHPHVVRGIDFFKLHGRYFIVMEYVRGITLKEFIIRYPHSIDFEKQLQIAIQICRGIANLNEYDIVHRDIKPTNIILTEENLLPKILDLGIAKSINSDLVSITHNDLIGTPQYMSPEQIEDKWDVGKNTDVFALGVLFYQFFSWSRSSPFHSETMVSTIQKVLHFNPPPLFPGDKEKSFVAYTIFQALQKNPQQRIDSVKTIIEMFSNRESKFPVTDENIRQPHVVARPSRYKRVQKKKGNSKSIAFVVLSMFFAIGIVWIFSQEKSHTNRVEKNISERRSTNKKVRAIPHEADRTKQTINWELYQQHMIRGVSYHEQKKYREACKHYTKAVTMNPQDFLAYCNRGIAYRELGKLKEALNDFNKAIELNPNDSDSYFNRGNVYNDVRNEKQAVADYSSAIRLNPRSHIAYTSRGDMYVDLGKYEEALDDFNQAVKIKPNYSRVYVSRGLLYKHLKKYNKALIDYLKALQLDPNDAFAHTNLGNIYNIQNNYQKALASYNNALRLSPDNGKIYLNRANIYYQQRQFEWALRDLNKALQLSPNNHQVYDSRKLVYEQLGRYEEALDDYNKIRHLNTDNYFFYAGRAIVYKRLRRYDKALEDFDKSIELNPAEYTTYVNRGLIYERQKRYEKVVEDYNTAIRLNPNDYLIYSNRGIVFNTLQRYREAIQDFNQAIALNPNDYVSYGTRGAIYVNQGAYTQALSDLNKAIKLNPRDGEYYGNRGVVYYHQQKFAKAISDWEKSMALGGPIDILKIRIEEAKKLLQK
>NZ_AP019860.1|WP_151969988.1|5833782_5835756_+|oligopeptide-transporter,-OPT-family
MIVLFIEETMEEKKHNPYVSPTENLPEFTFKAVICGIVFGVLFGAANAYLGLRAGLTISTSIPVAVMTVAIFRVFHKAGVQNSILEANLSQTIGSASSSVASGVIFTLPALFLWGLPPTLLQMTLLAMCGGLIGVLFMVPLRRFLIEKEHGLLPYPEGTACAKVLVASESKDNQANYVFWGLGLGMLFKVVFGWLKLVPSKATLKIPFIKKAQLGFDMSAALFGVGYILGPRISSIMVAGGLLSWLVIIPAIAYWGDGRMTPLYPEGTLLISQMTAKQIWHSYVRYIGAGAVAAAGFITLAKSIPTMIQSFRIGAEQLKKRLEQDGEQQLRTDQELSLKTVGGGLLVIAAVMAFVPTVFGSELSPVVRILASVLVVIFAFFFVTVSSRIVGMVGVTSNPTSGMTIATLLITSSIFLMFGWTDNVGKATALTVGCVVAIAASISGDTSQDLKTGFLMGATPRKQQLGELVGVMTSAAFVCLSVILLNEAYQFGSEELAAPQATLMKLVIEGVLESSLPWTLVGIGVVIAVIVELLKLPSLAFAVGVYLPVSTMTTVFLGGMLRKVLEKKTTPQEKEKRANRGILLGSGLVGGEGLIGVLIAGMAFTQSYLTPAGEKVKVWFFGYDWAQNIAWWAPSLFAVVIFFLLVSAFTQLCVKGK
>NZ_AP019860.1|WP_151969987.1|5828106_5833650_+|ATP-grasp-domain-containing-protein
MNKHKGILKKNARIAIVNRGEAAIRFIRAVNDYNFLHNTKLSTIAFYIPNEENSLFVKRANEAYNFSDFEKKPSTVSPYLNYDLLINALKKTKCDAVWPGWGFVSEDDHFVSLLEEKGIVFLGPSAKAMAALGDKIEAKKIADKAKVPILPWSKKALKTVEEAAKFAEKIGYPVILKAANAGGGRGIRMVRTPKELEKQFASAREETLRITNNDHIFMERMVEVSRHLEVQTLVDSHGNVNTFGVRDCSVQRRNQKVIEETPPPNFSEKLMTSIQKDAAKLLKAAKYRSAGTVEFIYDVPREEYYFMEVNTRLQVEHPISEQIYQVDLVQGQIDVAFGKEVKFDCSARGHAMEVRLNAEDPENDFIPAPGLISVLKMPAGSGIRVDSGVEQHSEIPTDFDSMIAKIISYAPNREMAIAKLKRALEEMHIKIEGGITNRAFLLELLNSKEVVNGVADTKFIERFLNKKRPQGKSWHIALVSCAIESYLKEYREELQNFQQQFSKSGYLRNVPSPTGREIELQLAGNSYVFFVKSVGGNVFHVLIDKTLVVVTYLPRDDQRVLIYEGKRFVIQNIERGDTIICEVDGVPHPIEMDSQGVIKSAAPAMVINVLKKEGDTVQKGDVILTLEAMKMETAIFAAESGVIKSLHVQKGEQVAAGQPLVSVDSKEQESGEKAPKAKRVDFKSISKGKNFKNKSERTWEVLEQEFLAIFLGYDAAQQATIWSDMQQFVDKNPAYQKKLYKTLIKATEIFISIESLFTSKRFGTESSAQALNCQELLAHFFKRTEDREKGLPEAFIERLEKAIRWYTYRSLNHYETINRAIFRIYKSYANSKSKASVLQTALFAVKDIAFFQKERYDRDLLGSLLDKLIRESQLRYPSLVDGAFHARYHLVDGPNLTEIRNENRQELLEAFDTLLDKDVADSDEYIEKIINSGNYINFELINLTFDKDVDKKQLALELLARRFNRYRKFHSGKVVQQNNSYFYHLKYTEKRKTMHFVLGVISTIKYKNRIKDFYEYIEESKLDSPEIMLFVSSPGNKDEKKEEEFIAKLNTCSQKIKNFYLGFFYKDLEFTYRTIEQGNDDTWQENEQRRYFSPLIYNELRVERLRNFHLELLNKTKTVYLLRATAKDNKKDQRLFVLCNVTDTNPQYDEEQYITSIPTLEHSITEAIYMIRTYQAAYGTRLYWNRIIMHIRSPLDIKLKLIEKYAKKLAPRFYGLGLEKTVIYAHTDLEKPEKEMEFLFENISGLHFSIRGRQISKAPLEPMDHYVAKNVRCRRRGIVYPYELIKMLTRPGHSNSENLPRGVFKELDLQFDENTKQHKLVSVADRPYGKNTSNIIFGIIINFSKNHPYGLKRVLILGDPSGDMGSLAEEECRRINAAIDYAQQHKLPVEWIPISSGARIDMRSGTENLDWTASTLRRIIEFTQQGGEVNMIVAGTNVGAQSYWNAEATMLMHTPGLLIMTSDASMLLTGKKALDFSGSVSAENNLGIGGAERIMAPNGQAQIWVDNLTEAYQVLFRHYDVTYRAPGCTFPMKRETKDSVNRNVSEASYSDSLGQGFEKVGDIFSIEKNRERKKPFDMRQIMQAVVDRDFGYLERWNLMKDAEIGIVWETRIGGHSVGLLGIESRPLTRIGPLANDGPETWNGGTLFPQSSKKIARAINSYSDCMPLVILANLSGFDGSPESLRNFQLEYGAEIGRAVVNFKGPIIFVVTARYHGGAYVVFSRSLNPHLRVAAIEGTYASVIGGAPAAAVVFPKKVQKETYSDSSVITAQKDLAAGKISQGEFKQIFQRVYTEKQNDLAQEFDSIHSVERAQTVGSLHDIISAKNLRPYIIDSLEKMIEKYLSDMDI
>NZ_AP019860.1|WP_151969986.1|5827314_5827935_-|metallophosphoesterase-family-protein
MKLLLFSDLHCNNMAARFLLHCAQSVDIVIGAGDFCSAHRGLHPILTILKNISQPMIFIPGNNETDNALRQECSGLENVHVLHGNGCSLHGIEFFGVGGGIPITPFGKWSFDFSEIQAEELFASCPDNAIIVSHSPPKGIVDVSSSGKSLGSTTVRKVVEEKSPRLVVCGHIHGSEGQIEKLNDSYIINAGPAGIIWDLDKNVIVT
>NZ_AP019860.1|WP_151969985.1|5826282_5827266_-|glycosyltransferase
MEISVIIPTFNRSLFLPKCIQSVLLQNYPVKEIIIIDDFSDDNTTLVVENLIKENQTQTKIIYLKQTKNQGVSSARNLGLNAAQYNIVLFLDSDDYWEQDYTSNVVNIFEKYQDVSIIFTRLNVIDSSNRLSAEQLMVKEKKIRFWRQCCESKDELFFAPTQQVKRHVLMQQLTFFLSALAINKSRMDCPVFFDSNLYFAEDHEYLVRLLDNAKTVAYTDKPLSNYVIHGSNTVLANADYQKHMRNLHGGISSCLKMLACCDNADEYQFLLEYIINKFRLIGWLKQDQNDRHGAYEAFRNSYLFSRKWKDLLRVWKAKLYLVFFHKH
>NZ_AP019860.1|WP_151969984.1|5825322_5826279_+|hypothetical-protein
MVAQGKRRFLKNIIIMSIVSICTLVLMTIIIYERQQHLIAGQPFSIYAIAFLLLFSFCTFLVLFFPRSNTLILSFKDEAHLSSLVKIMLYPFVLLVLISHSLFQFHSTLCLFSLWMAMLMIITKNIYLFCKKMDKIDTMNLRTTLVAMSKVLWEKTLYTTWHTLFYAFIMSILFPRYHGNIPQYQNISSYIVVWANAWGHYFLWTLACFLLCQFVAMAFGSFLYKRNHVFFGVTVLFFLSLAPTAPIWLLDHLYSSWVLPYNNYVDYEYATIIANKSRAFLYTLSVMLLCCVIVLYNLYRKNNFVEEDANDYSTSFRE
>NZ_AP019860.1|WP_151969983.1|5823579_5825199_+|hypothetical-protein
MISKLPLLQKELIEYASTKRLFILRVLFGLCLYTIFLVNWSNYTSSDNLYRVLGSGRWLLEYIYIINIIAIFVILPMSSACVITNEKEKRTLSLLLTTQLGPTLILFEKFISLVISIFSFLLISFPAMYLAYLLGGLTNKKILISLYAQFLTVVQVAAVGLFFSCYCKTSIKAIMATYIWGFALYIFFPFFEIFDNVSYYLEIVMFPPAFYYYLDSYASGPWEMFAYTIPIWISAALFLLGARHFLITYPQRMNKKPMAQKVRDDFHIVKRKVPHIRLPILWREGSHSSWPFAAKIFFILGAVIGVGFFGSLPSSRGNRHEFAMIIYFFALAICALFLTMRSVTLFQREIKQETWDVLLTTTMTTRSIFWQKAMAVTRFTLYICILLLCIYTFNLAAFPRSYYSSSRLPSGARWTYAVVFTFLIFTNIQWFMMWLGLTFRKNTKIALVAVGLIAAWCIMPILVSEFAREILGGSRSNYRVLALFSPFAIFIAVTDGRIPGYSNRMYTAMNIGFVIFAVQAVVFYVAASISSQKHIRVCD
>NZ_AP019860.1|WP_152022041.1|5822660_5823569_+|ATP-binding-cassette-domain-containing-protein
MTVRYDEFIAVHTMNLQIPPGEVFGFIGPNGAGKSTTMKVLATLLKPQIGKVFLDGIDVLREPKKIRSIIGYMPDAFGVYDDLSVQEYLHFFAAAYRIGWSQRKKLVDDLLALTDLTKKKYSQVDSLSRGMKQRLGIARVLLHDPKFLILDEPASGLDPRARIEMRELLKELRNMGKTIMISSHILSELSELCTRIGIIEAGKIVAEGSLEEIYTQLGVEKIIHTQILNYDDDLQVKIAAIPGVASVQKEQNRVEIHIKEQELKPEELLENLISLKACVRMFQPGAIDLETVFMKLTEGKTA
>NZ_AP019860.1|WP_151969982.1|5820769_5822635_+|hypothetical-protein
MKWTLLTLLCLFVLQAQAQVQLVMNDKKMIRENAPVQLKFSLSSSRNVKGKFALYYGEDILFYRSKELILTAGQNNYQLWLPPLTNFYYEAFFETQDDIIALGNVDLGRKIDLLITTSFSQSTAIEQACNVYALLPQNRQGQKPYISYKRISPNEIPQSLITAYCDTDLLLLHSGHLNFMSEEQIHIVEKWICMGGSACIVIGKDSLFKQYHLDFISRMSAMESIHNYTKNIHSSRHGLGRVVLCDFSQQPSDSFSFVSSEWKKMILWLWKIKESIATEIVYSKKRYLEDFDYYYTTTDWRDRYRYRYRRSRAGAGSIGNYLLPKSVQIPPTWLLSLLLFSFLVLVGPIEYIVLKKLNKRVLTWITFPIATLCFWALCQWVADVYLGEVKTSKVLHIVDIGSQKQVARSNDLHFFMSSKPQKITNTIENSIQVNLDANVNYYNNYNTNENCSYDGAFPTQFSVTQNLQKWTPYMRKVFRQTSEFELVENFVPRLTENIKDFQATIMRNAYDRSLSGPRSVATSRNYPGVENFDYIYIIHKGYVYAAKGSPNGLVQGILHFSYAFPSDERILFAQKSPSGGSDALSDLTLHDPTDSSQYVVVLIREQQNKIIVFRYLYYKGA
>NZ_AP019860.1|WP_151969992.1|5840056_5840758_+|hypothetical-protein
MKKLNVMDLGLGNYTQVLRLQKEIMEKRARGEVEDTLILVEHPTVITLGVKANEQSIKVTKEYLAENGIEVHEILRGGAAFLHSPGQIVGYPIFLLEANERRAYLETIQQMMMDLTEEHKIPAVLHPNKDYIGVWYEVESGAYKKIGAVGMRFVNRNDQYVTLHGFALNVNNDSSIVEKLIFMCGCPSETCISWKEITQKTFDLSQIKENIIHKLAKDLHYNTVYTNKKNNHH
>NZ_AP019860.1|WP_151969993.1|5840810_5841701_+|lipoyl-synthase
MNKLYNKPEWLKIKIEHDPKFDDVRKTLSENSLVTVCEEAHCPNINECWSSGTATFMVLGDTCTRGCRFCNVKSGRYGANIDPMEPMKIAESVKKWGLDYIVITSVDRDDLPDQGSEHFAKVITTVHQQSPEVLIEVLVPDFRGDVKCVETVVQARPNVFAHNVETIERLQGRVRDNRATYEQSLMVLEYAKKQGLYTKSSLMVGLGETEEEIAQTMDDLRRIDVDFLTLGQYLRPSLKHLEVVEYVHPDQFEHYKKIGLEKGFRYIAAGPFVRSSYKAGEFFIKSIVKENGNDGA
>NZ_AP019860.1|WP_173013472.1|5841687_5841924_+|hypothetical-protein
MMELKFPDLGNGISEGQVIKWLAKEGEVVQKSQNVLYVETFKTMIEIPATSTGKIRQQKCKIGDMVKAGDVIAVIDAD
>NZ_AP019860.1|WP_151969995.1|5842040_5843030_-|hypothetical-protein
MLFTSTKKSIIFAICLCTLISLTAEKMEDYQFQGGISYSNEGSFVWANVSHDGDDIKEASVTVNDIQLVYQEQHGMYTAKLHDVQGGSLVKVIAKSAKGEVFFHRTAQIPQLATITQLSMRKDHSYSMGWTRTNATLLEATYETLSKNHPQNRGEFTTVVPSDKSTIIIPANNIVNGHAKFSICAFGGDIQLARGEKSSSWFITKAIDSRSHHISHAQHHDVKNEYPGAPLQEVSEWDDKKDGVKIHFRAYDPLQIVQEGKLHLHIKLKNNRVAVAVVVIDGEKVWFEKRIHKSKDKVYTVVLDVSVGAQVVLGTQACKIYAFNYYVAK
>NZ_AP019860.1|WP_151969996.1|5843257_5844310_+|hypothetical-protein
MRLFFFCICTFIFSSVIVADNENCTPQQHNGKPHIIVTHIYARDFLYEEKNVDWESEIRALSSVKRVHRRYGTSIFDGARGVGISAEEGISWPDIRGHRVRFLTKKQLNSPVDEIGIIVSFSFLKSRRYLPYDANLHEKDTWENVLLPSKIDLEVDSWHGKSTIPVPVIGVVADEFLPKPYVITCGFLEILRNWRSEFLYMLKNRKNEPLVLPPAQSIYYTLTESQRMWLQDNEKVVEQIEEKLSIPVFVDFWDNGEAIQCRLVIEPEEEISRKKVKEIDEHLRSYTELRDLPEAMVDFIPVWKWENVEFYRKYDADHFAIYLKNNDQNVLQELKKIGLKIIWFRNDTRY
>NZ_AP019860.1|WP_151969997.1|5844444_5846262_+|hypothetical-protein
MLHILSISFICLTAIQITRAWFPLLYSFAEKIGFYNIPVFVLVVSCIPILGLLLKRFHSYGIVIVGSYLALLRVIIQLFAMNFWIMFVGISLFLVVLPLAVIDIRKSTRANDFVCGLLFAMAIDTTLQTFHHTWDYIWQRDYFSFALTVIIALITVYCVWKRKKQPQQDELLVIPWWISCYLAIQTVLLHNIAFVAASAQCSIFVASVVIIAADIVAIGSLFFPVKISLRVPVVAIIVYSIHCLFTGQFIFPALFAAQLALNFLLRMYLQPVAAHQENNYASYVSTLVVCTLYALTILLYQLHYESPLPFSNIWLFIAPFVAVVVISMDNSQKYTNEKPPLAAIGAMIVAIISVAIFGSLQPQITENVSEKAQFKMVCYNIHEAVNARGVLDPETIAQIMEQNQVHAVLLQEVGRGWPISGMIDLAHWFQNRLRMKLVYAPAASVKFGNAILTNLKITEKGHKMLPQGTGSMGRSYVYVRLQLGKELVYVVNTHLQHKKKNTLVRIQQINELLNNWNLTPHTIIAGDLNSQPNGEEMKLFSKDRWVSAQDITKYDYPFTFQKGKGSEKRIDWILGSKDLSFHDFYIIKSDASDHLPLFTSVKVKK
>NZ_AP019860.1|WP_173013473.1|5846374_5846941_+|hypothetical-protein
MNIGGNFNHGIEIPRSPPKQTSLSDLKEETGKLASEKKLEMKPISEMNMSEKRKLEKLKLRDQEVRTHEQAHVAAGGKYIKSAIHYDYQVGPDGRKYAVGGNVKIDSQPVPNQPQETIAKMQVVRKAALAPAQPSSADHQVAQKASSEEAKARQELAQKKLEEQATEKYSFHQQQGESDSQDNFSIVV
>NZ_AP019860.1|WP_152022042.1|5847161_5847746_+|heme-binding-protein
MFGCTSYERPNYKVIQTYDHFELRHYPAHIVAETQVNASFDKAGNKAFRRLAGFISGANSKQQKIAMTAPVNQQASEGETIAMTAPVNQINIAKDKYMIEFIMPQKYTMETIPQPTNPKVKIRQIPAKIMAVRKYKGSWSQVKYNKNKEMLLTNVQQAKLEANGNPIFARYNSPFTIWFLRENEVLVEIKNAAR
>NZ_AP019860.1|WP_173013474.1|5847813_5848248_-|hypothetical-protein
MNKIYVVVMALFVVCSYGFCDAIYTGSGYYLRAEYGGGGKVDAKAKKRGEWEEWQLIPQEDGSYAIKSSGGFYLSAKNSGGGKVDARHRKIGLSQKWRRQSVGGGYFTFKTSKGYYLQAKNNGGGKVDARSKKMSEGAKWKILK
>NZ_AP019860.1|WP_151970000.1|5848358_5853134_-|protein-kinase
MDEDRIKKIWKDVIPEEELENSNPGSTYKSVKLEKGTIASLELPFITLTSDAAQQENSDEEKDTRSTASGGKNHFATALTLKYEDDTRRIGGYATTTLNYELLDEIARGGMGVVFKGKQLSLRREVAIKKIKSAKEDVANKDKFISESLVTAYLDHPNIVPVYDLGQNEKEEVFLAMKLVGGTEWKSLLNPKTAQDKELAQKYNIEKHLGILINVCNAIAYAHSKKIVHNDLKPSNVMVGEFGEVLVMDWGIAVDIRDSDERGDETMTMHRSLVKSPMGTPHYMPWELAEGAGTNIGPWTDVYLLGGILYHILMRTPPHRGGTLEALVSAITGKLPAFPKAIPKELQQICSKALSKEISQRYQSVSDFQKALQGYLQHSESLVISAKARNILKECLQVEQKLLLEKERNKLYAKFAQAVSGFEQALELWQENEEAMRGQHAARLAYANVALINEDFGLADAQIAPVTETGEIKQLKVKIAEARIKKIQMEQATKKLRITVYAALIFIIAGLTVGFLLVNRAQQELAKEKKTVEQQKDAIQQQKDAITKQLAEIGLKKAEEAYQKSLLEDEEININSYMKQERAYRECGAYAGKALDYLRELKDFDDLQNKGRAFVKLALQQRKEVWHSPSYGHSGSPGSLTFTHDDQAIVSIYDDNKLQLWNVKTGKEVAQFKKYMRNALTIAFSADGTILACGMGEFDEEQEEYRDCQVKLWNVKTGREVLRFTKHKMPVKHVVFSEDGNTIFSSSGNNTARLWNINTGKQLSHIQHADTINSAAFHHNNKILATASSDKTVKLWNIQTGKEILQLKGHSDMVTSIAFAKGSKILASASEDQTIRLWDTTSGQELSKIVAHSDAINSIKFNHDGEILASASRDHTIKLWDLQTRKSFLSLTGHTATVNAIAFSHNDQILASASEDHTIRLWNTVSGKELSQIAGHTAAIHSTAFSHDGEILASASRDHTVKLWDTKTGKKLFHLKGHDAAVNAVAFSRHNILASASEDRTIKFWNTTTGQQLSQITAHNATIHAIAFGHDGKTLASGSEDHTIKLWEVETGEELLHLQGHSDTVNAVAFSNDGKFFASASSDKTVRLWDSITGKQLSVFTAHTGKVYSVAFSPNSKMLASSSGDEYGNDCAIKLWECETRKEIAHFVGHDYTVYSVAFHPGGQILASGSYDNTVRLWNIQTGKQISKITGHSDVVYTVAFSPNGSRLASGSGDQSLKVWDVNITNSFLRITPSPHKVNTVAFHSDSKIIASGSWDGKIALWDTTTGKNVANFVGHTGKVHSLAFSHSGKILASGAGIYDDDNEEYQDCSVRLWDVDKGKELIRCNGHNEPIKSVIFSRDGQIVASGSWDNTVRLWDTTTGKELLMLNGYSRNIRSIAFSPQNKMIASSWDGAIRIWNITTGKEIMTLHGHTDDISCLVFHPNGKLLASGANDNTIRLWEIATGKLVSILTGHTSYVLSIAFSPDGNTLASGSWDKTIRLWNVTTGKEFSKLVGHSQSVNSVAFSPNGKILGSGSWDQSVRLWNIEKNKTLPWFDSMGNDKRDSFYSTLQKTPQELTKRLFGLQVNQNMELEPYVYQQRLWQPLKVDFLDK

Crispr_ID: NZ_AP019860_25

• CRISPR_ID: NZ_AP019860_25
• CRISPR_location: 5839422-5839651
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_AP019860_25

Consensus_repeat	Method
CCGATTTCTTTGGGGAGTTCTGT	CRISPRCasFinder

spacers of NZ_AP019860_25

>25.1|5839445|46|NZ_AP019860|CRISPRCasFinder
GATCTGTGTTGCGCTCAAATCTAAAAAATCGAGAGCTGTGAGTTGA
>25.2|5839514|46|NZ_AP019860|CRISPRCasFinder
TATGTTACAATGGCCTAAATCAAGTTCGGAAAGAGAAGTGAGCCGC
>25.3|5839583|46|NZ_AP019860|CRISPRCasFinder
TATATTTGTTGAATTCAACAGCAAACCAGTGAGAGAAGTGAGTTGT

CRISPR arrays and Neighbor proteins around NZ_AP019860_25

CRISPR arrays

The CRISPR arrays of NZ_AP019860_25

>merge|NZ_AP019860|25|5839422-5839651|CRISPRCasFinder
CCGATTTCTTTGGGGAGTTCTGTGATCTGTGTTGCGCTCAAATCTAAAAAATCGAGAGCTGTGAGTTGACCGATTTCTTTGGGTAGTTCTGTTATGTTACAATGGCCTAAATCAAGTTCGGAAAGAGAAGTGAGCCGCCCAATTTCTTTAGGAATTTCTCTTATATTTGTTGAATTCAACAGCAAACCAGTGAGAGAAGTGAGTTGTTCAAATTCTTTGGGTAGCTCCGT

>NZ_AP019860|25|21|5839422-5839651|CRISPRCasFinder
CCGATTTCTTTGGGGAGTTCTGT	GATCTGTGTTGCGCTCAAATCTAAAAAATCGAGAGCTGTGAGTTGA
CCGATTTCTTTGGGTAGTTCTGT	TATGTTACAATGGCCTAAATCAAGTTCGGAAAGAGAAGTGAGCCGC
CCAATTTCTTTAGGAATTTCTCT	TATATTTGTTGAATTCAACAGCAAACCAGTGAGAGAAGTGAGTTGT
TCAAATTCTTTGGGTAGCTCCGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151969986.1|5827314_5827935_-|metallophosphoesterase-family-protein	unknown	unknown	gnl|CDD|277338
NZ_AP019860.1|WP_173013473.1|5846374_5846941_+|hypothetical-protein	unknown	unknown	gnl|CDD|288934
NZ_AP019860.1|WP_151969988.1|5833782_5835756_+|oligopeptide-transporter,-OPT-family	unknown	unknown	gnl|CDD|224216
NZ_AP019860.1|WP_151969996.1|5843257_5844310_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969995.1|5842040_5843030_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969984.1|5825322_5826279_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969987.1|5828106_5833650_+|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|227111
NZ_AP019860.1|WP_151970000.1|5848358_5853134_-|protein-kinase	unknown	unknown	gnl|CDD|238121
NZ_AP019860.1|WP_173013474.1|5847813_5848248_-|hypothetical-protein	unknown	unknown	gnl|CDD|238160
NZ_AP019860.1|WP_151969985.1|5826282_5827266_-|glycosyltransferase	unknown	unknown	gnl|CDD|366154
NZ_AP019860.1|WP_151969989.1|5835856_5838334_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151969997.1|5844444_5846262_+|hypothetical-protein	unknown	unknown	gnl|CDD|226098
NZ_AP019860.1|WP_151969990.1|5838350_5838824_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_152022042.1|5847161_5847746_+|heme-binding-protein	unknown	unknown	gnl|CDD|377411
NZ_AP019860.1|WP_151969993.1|5840810_5841701_+|lipoyl-synthase	unknown	unknown	gnl|CDD|235493
NZ_AP019860.1|WP_152022041.1|5822660_5823569_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224054
NZ_AP019860.1|WP_151969982.1|5820769_5822635_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151969983.1|5823579_5825199_+|hypothetical-protein	unknown	unknown	gnl|CDD|224196
NZ_AP019860.1|WP_151969992.1|5840056_5840758_+|hypothetical-protein	unknown	unknown	gnl|CDD|319743
NZ_AP019860.1|WP_173013472.1|5841687_5841924_+|hypothetical-protein	unknown	unknown	gnl|CDD|237001

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151969986.1|5827314_5827935_-|metallophosphoesterase-family-protein	gnl|CDD|277338	cd07392, MPP_PAE1087, Pyrobaculum aerophilum PAE1087 and related proteins, metallophosphatase domain. PAE1087 is an uncharacterized Pyrobaculum aerophilum protein with a metallophosphatase domain. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	7.81619e-34
NZ_AP019860.1|WP_173013473.1|5846374_5846941_+|hypothetical-protein	gnl|CDD|288934	pfam12118, SprA-related, SprA-related family. This family of bacterial proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. Proteins in this family are typically between 234 to 465 amino acids in length. Most members are annotated as being SprA-related.	5.23492e-22
NZ_AP019860.1|WP_151969988.1|5833782_5835756_+|oligopeptide-transporter,-OPT-family	gnl|CDD|224216	COG1297, COG1297, Predicted membrane protein [Function unknown].	1.55246e-123
NZ_AP019860.1|WP_151969987.1|5828106_5833650_+|ATP-grasp-domain-containing-protein	gnl|CDD|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	3.27583e-173
NZ_AP019860.1|WP_173013474.1|5847813_5848248_-|hypothetical-protein	gnl|CDD|238160	cd00257, Fascin, Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an internal threefold repeat; the fascin subgroup contains four copies of the domain; Structurally similar to fibroblast growth factor (FGF).	4.02933e-10
NZ_AP019860.1|WP_151969985.1|5826282_5827266_-|glycosyltransferase	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	3.06397e-31
NZ_AP019860.1|WP_151969989.1|5835856_5838334_+|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.37194e-70
NZ_AP019860.1|WP_151969997.1|5844444_5846262_+|hypothetical-protein	gnl|CDD|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	8.9879e-19
NZ_AP019860.1|WP_151970000.1|5848358_5853134_-|protein-kinase	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	2.96422e-96
NZ_AP019860.1|WP_152022042.1|5847161_5847746_+|heme-binding-protein	gnl|CDD|377411	pfam04832, SOUL, SOUL heme-binding protein. This family represents a group of putative heme-binding proteins. Our family includes archaeal and bacterial homologs.	8.94507e-53
NZ_AP019860.1|WP_151969993.1|5840810_5841701_+|lipoyl-synthase	gnl|CDD|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	0
NZ_AP019860.1|WP_152022041.1|5822660_5823569_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	2.25689e-90
NZ_AP019860.1|WP_151969983.1|5823579_5825199_+|hypothetical-protein	gnl|CDD|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	3.40276e-06
NZ_AP019860.1|WP_151969992.1|5840056_5840758_+|hypothetical-protein	gnl|CDD|319743	cd16444, LipB, lipoyl/octanoyl transferase. Lipoate-protein ligase B is a octanoyl-[acyl carrier protein]-protein acyltransferase the catalyzes the first step of lipoic acid synthesis. It transfers endogenous octanoic acid attached via a thioester bond to acyl carrier protein (ACP) onto lipoyl domains, which is later converted by lipoate synthase LipA into lipoylated derivatives.	3.86385e-45
NZ_AP019860.1|WP_173013472.1|5841687_5841924_+|hypothetical-protein	gnl|CDD|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	2.72491e-19

Protein sequences

>NZ_AP019860.1|WP_151969990.1|5838350_5838824_-|hypothetical-protein
MKIYYLIAVCFFVACSSQIRCQFPKENCDALVKNEREHREKLAVEMGDLLKKNTYKKEDICKIVAEIDDMLNIIDANTNINSQWLKSKLASLRDLFPDIATKKTFTTHMKTPLDKCLIVDNCALQKDIYEIVKCHLCILRKTLSSTCDLQTEKCPCS
>NZ_AP019860.1|WP_151969989.1|5835856_5838334_+|tetratricopeptide-repeat-protein
MQILNNRYRFEKVLGQGGMGKVYLCTDINNQQLVAIKECVPKGQRTENTIRRINREYYFMSKIQHPHVVRGIDFFKLHGRYFIVMEYVRGITLKEFIIRYPHSIDFEKQLQIAIQICRGIANLNEYDIVHRDIKPTNIILTEENLLPKILDLGIAKSINSDLVSITHNDLIGTPQYMSPEQIEDKWDVGKNTDVFALGVLFYQFFSWSRSSPFHSETMVSTIQKVLHFNPPPLFPGDKEKSFVAYTIFQALQKNPQQRIDSVKTIIEMFSNRESKFPVTDENIRQPHVVARPSRYKRVQKKKGNSKSIAFVVLSMFFAIGIVWIFSQEKSHTNRVEKNISERRSTNKKVRAIPHEADRTKQTINWELYQQHMIRGVSYHEQKKYREACKHYTKAVTMNPQDFLAYCNRGIAYRELGKLKEALNDFNKAIELNPNDSDSYFNRGNVYNDVRNEKQAVADYSSAIRLNPRSHIAYTSRGDMYVDLGKYEEALDDFNQAVKIKPNYSRVYVSRGLLYKHLKKYNKALIDYLKALQLDPNDAFAHTNLGNIYNIQNNYQKALASYNNALRLSPDNGKIYLNRANIYYQQRQFEWALRDLNKALQLSPNNHQVYDSRKLVYEQLGRYEEALDDYNKIRHLNTDNYFFYAGRAIVYKRLRRYDKALEDFDKSIELNPAEYTTYVNRGLIYERQKRYEKVVEDYNTAIRLNPNDYLIYSNRGIVFNTLQRYREAIQDFNQAIALNPNDYVSYGTRGAIYVNQGAYTQALSDLNKAIKLNPRDGEYYGNRGVVYYHQQKFAKAISDWEKSMALGGPIDILKIRIEEAKKLLQK
>NZ_AP019860.1|WP_151969988.1|5833782_5835756_+|oligopeptide-transporter,-OPT-family
MIVLFIEETMEEKKHNPYVSPTENLPEFTFKAVICGIVFGVLFGAANAYLGLRAGLTISTSIPVAVMTVAIFRVFHKAGVQNSILEANLSQTIGSASSSVASGVIFTLPALFLWGLPPTLLQMTLLAMCGGLIGVLFMVPLRRFLIEKEHGLLPYPEGTACAKVLVASESKDNQANYVFWGLGLGMLFKVVFGWLKLVPSKATLKIPFIKKAQLGFDMSAALFGVGYILGPRISSIMVAGGLLSWLVIIPAIAYWGDGRMTPLYPEGTLLISQMTAKQIWHSYVRYIGAGAVAAAGFITLAKSIPTMIQSFRIGAEQLKKRLEQDGEQQLRTDQELSLKTVGGGLLVIAAVMAFVPTVFGSELSPVVRILASVLVVIFAFFFVTVSSRIVGMVGVTSNPTSGMTIATLLITSSIFLMFGWTDNVGKATALTVGCVVAIAASISGDTSQDLKTGFLMGATPRKQQLGELVGVMTSAAFVCLSVILLNEAYQFGSEELAAPQATLMKLVIEGVLESSLPWTLVGIGVVIAVIVELLKLPSLAFAVGVYLPVSTMTTVFLGGMLRKVLEKKTTPQEKEKRANRGILLGSGLVGGEGLIGVLIAGMAFTQSYLTPAGEKVKVWFFGYDWAQNIAWWAPSLFAVVIFFLLVSAFTQLCVKGK
>NZ_AP019860.1|WP_151969987.1|5828106_5833650_+|ATP-grasp-domain-containing-protein
MNKHKGILKKNARIAIVNRGEAAIRFIRAVNDYNFLHNTKLSTIAFYIPNEENSLFVKRANEAYNFSDFEKKPSTVSPYLNYDLLINALKKTKCDAVWPGWGFVSEDDHFVSLLEEKGIVFLGPSAKAMAALGDKIEAKKIADKAKVPILPWSKKALKTVEEAAKFAEKIGYPVILKAANAGGGRGIRMVRTPKELEKQFASAREETLRITNNDHIFMERMVEVSRHLEVQTLVDSHGNVNTFGVRDCSVQRRNQKVIEETPPPNFSEKLMTSIQKDAAKLLKAAKYRSAGTVEFIYDVPREEYYFMEVNTRLQVEHPISEQIYQVDLVQGQIDVAFGKEVKFDCSARGHAMEVRLNAEDPENDFIPAPGLISVLKMPAGSGIRVDSGVEQHSEIPTDFDSMIAKIISYAPNREMAIAKLKRALEEMHIKIEGGITNRAFLLELLNSKEVVNGVADTKFIERFLNKKRPQGKSWHIALVSCAIESYLKEYREELQNFQQQFSKSGYLRNVPSPTGREIELQLAGNSYVFFVKSVGGNVFHVLIDKTLVVVTYLPRDDQRVLIYEGKRFVIQNIERGDTIICEVDGVPHPIEMDSQGVIKSAAPAMVINVLKKEGDTVQKGDVILTLEAMKMETAIFAAESGVIKSLHVQKGEQVAAGQPLVSVDSKEQESGEKAPKAKRVDFKSISKGKNFKNKSERTWEVLEQEFLAIFLGYDAAQQATIWSDMQQFVDKNPAYQKKLYKTLIKATEIFISIESLFTSKRFGTESSAQALNCQELLAHFFKRTEDREKGLPEAFIERLEKAIRWYTYRSLNHYETINRAIFRIYKSYANSKSKASVLQTALFAVKDIAFFQKERYDRDLLGSLLDKLIRESQLRYPSLVDGAFHARYHLVDGPNLTEIRNENRQELLEAFDTLLDKDVADSDEYIEKIINSGNYINFELINLTFDKDVDKKQLALELLARRFNRYRKFHSGKVVQQNNSYFYHLKYTEKRKTMHFVLGVISTIKYKNRIKDFYEYIEESKLDSPEIMLFVSSPGNKDEKKEEEFIAKLNTCSQKIKNFYLGFFYKDLEFTYRTIEQGNDDTWQENEQRRYFSPLIYNELRVERLRNFHLELLNKTKTVYLLRATAKDNKKDQRLFVLCNVTDTNPQYDEEQYITSIPTLEHSITEAIYMIRTYQAAYGTRLYWNRIIMHIRSPLDIKLKLIEKYAKKLAPRFYGLGLEKTVIYAHTDLEKPEKEMEFLFENISGLHFSIRGRQISKAPLEPMDHYVAKNVRCRRRGIVYPYELIKMLTRPGHSNSENLPRGVFKELDLQFDENTKQHKLVSVADRPYGKNTSNIIFGIIINFSKNHPYGLKRVLILGDPSGDMGSLAEEECRRINAAIDYAQQHKLPVEWIPISSGARIDMRSGTENLDWTASTLRRIIEFTQQGGEVNMIVAGTNVGAQSYWNAEATMLMHTPGLLIMTSDASMLLTGKKALDFSGSVSAENNLGIGGAERIMAPNGQAQIWVDNLTEAYQVLFRHYDVTYRAPGCTFPMKRETKDSVNRNVSEASYSDSLGQGFEKVGDIFSIEKNRERKKPFDMRQIMQAVVDRDFGYLERWNLMKDAEIGIVWETRIGGHSVGLLGIESRPLTRIGPLANDGPETWNGGTLFPQSSKKIARAINSYSDCMPLVILANLSGFDGSPESLRNFQLEYGAEIGRAVVNFKGPIIFVVTARYHGGAYVVFSRSLNPHLRVAAIEGTYASVIGGAPAAAVVFPKKVQKETYSDSSVITAQKDLAAGKISQGEFKQIFQRVYTEKQNDLAQEFDSIHSVERAQTVGSLHDIISAKNLRPYIIDSLEKMIEKYLSDMDI
>NZ_AP019860.1|WP_151969986.1|5827314_5827935_-|metallophosphoesterase-family-protein
MKLLLFSDLHCNNMAARFLLHCAQSVDIVIGAGDFCSAHRGLHPILTILKNISQPMIFIPGNNETDNALRQECSGLENVHVLHGNGCSLHGIEFFGVGGGIPITPFGKWSFDFSEIQAEELFASCPDNAIIVSHSPPKGIVDVSSSGKSLGSTTVRKVVEEKSPRLVVCGHIHGSEGQIEKLNDSYIINAGPAGIIWDLDKNVIVT
>NZ_AP019860.1|WP_151969985.1|5826282_5827266_-|glycosyltransferase
MEISVIIPTFNRSLFLPKCIQSVLLQNYPVKEIIIIDDFSDDNTTLVVENLIKENQTQTKIIYLKQTKNQGVSSARNLGLNAAQYNIVLFLDSDDYWEQDYTSNVVNIFEKYQDVSIIFTRLNVIDSSNRLSAEQLMVKEKKIRFWRQCCESKDELFFAPTQQVKRHVLMQQLTFFLSALAINKSRMDCPVFFDSNLYFAEDHEYLVRLLDNAKTVAYTDKPLSNYVIHGSNTVLANADYQKHMRNLHGGISSCLKMLACCDNADEYQFLLEYIINKFRLIGWLKQDQNDRHGAYEAFRNSYLFSRKWKDLLRVWKAKLYLVFFHKH
>NZ_AP019860.1|WP_151969984.1|5825322_5826279_+|hypothetical-protein
MVAQGKRRFLKNIIIMSIVSICTLVLMTIIIYERQQHLIAGQPFSIYAIAFLLLFSFCTFLVLFFPRSNTLILSFKDEAHLSSLVKIMLYPFVLLVLISHSLFQFHSTLCLFSLWMAMLMIITKNIYLFCKKMDKIDTMNLRTTLVAMSKVLWEKTLYTTWHTLFYAFIMSILFPRYHGNIPQYQNISSYIVVWANAWGHYFLWTLACFLLCQFVAMAFGSFLYKRNHVFFGVTVLFFLSLAPTAPIWLLDHLYSSWVLPYNNYVDYEYATIIANKSRAFLYTLSVMLLCCVIVLYNLYRKNNFVEEDANDYSTSFRE
>NZ_AP019860.1|WP_151969983.1|5823579_5825199_+|hypothetical-protein
MISKLPLLQKELIEYASTKRLFILRVLFGLCLYTIFLVNWSNYTSSDNLYRVLGSGRWLLEYIYIINIIAIFVILPMSSACVITNEKEKRTLSLLLTTQLGPTLILFEKFISLVISIFSFLLISFPAMYLAYLLGGLTNKKILISLYAQFLTVVQVAAVGLFFSCYCKTSIKAIMATYIWGFALYIFFPFFEIFDNVSYYLEIVMFPPAFYYYLDSYASGPWEMFAYTIPIWISAALFLLGARHFLITYPQRMNKKPMAQKVRDDFHIVKRKVPHIRLPILWREGSHSSWPFAAKIFFILGAVIGVGFFGSLPSSRGNRHEFAMIIYFFALAICALFLTMRSVTLFQREIKQETWDVLLTTTMTTRSIFWQKAMAVTRFTLYICILLLCIYTFNLAAFPRSYYSSSRLPSGARWTYAVVFTFLIFTNIQWFMMWLGLTFRKNTKIALVAVGLIAAWCIMPILVSEFAREILGGSRSNYRVLALFSPFAIFIAVTDGRIPGYSNRMYTAMNIGFVIFAVQAVVFYVAASISSQKHIRVCD
>NZ_AP019860.1|WP_152022041.1|5822660_5823569_+|ATP-binding-cassette-domain-containing-protein
MTVRYDEFIAVHTMNLQIPPGEVFGFIGPNGAGKSTTMKVLATLLKPQIGKVFLDGIDVLREPKKIRSIIGYMPDAFGVYDDLSVQEYLHFFAAAYRIGWSQRKKLVDDLLALTDLTKKKYSQVDSLSRGMKQRLGIARVLLHDPKFLILDEPASGLDPRARIEMRELLKELRNMGKTIMISSHILSELSELCTRIGIIEAGKIVAEGSLEEIYTQLGVEKIIHTQILNYDDDLQVKIAAIPGVASVQKEQNRVEIHIKEQELKPEELLENLISLKACVRMFQPGAIDLETVFMKLTEGKTA
>NZ_AP019860.1|WP_151969982.1|5820769_5822635_+|hypothetical-protein
MKWTLLTLLCLFVLQAQAQVQLVMNDKKMIRENAPVQLKFSLSSSRNVKGKFALYYGEDILFYRSKELILTAGQNNYQLWLPPLTNFYYEAFFETQDDIIALGNVDLGRKIDLLITTSFSQSTAIEQACNVYALLPQNRQGQKPYISYKRISPNEIPQSLITAYCDTDLLLLHSGHLNFMSEEQIHIVEKWICMGGSACIVIGKDSLFKQYHLDFISRMSAMESIHNYTKNIHSSRHGLGRVVLCDFSQQPSDSFSFVSSEWKKMILWLWKIKESIATEIVYSKKRYLEDFDYYYTTTDWRDRYRYRYRRSRAGAGSIGNYLLPKSVQIPPTWLLSLLLFSFLVLVGPIEYIVLKKLNKRVLTWITFPIATLCFWALCQWVADVYLGEVKTSKVLHIVDIGSQKQVARSNDLHFFMSSKPQKITNTIENSIQVNLDANVNYYNNYNTNENCSYDGAFPTQFSVTQNLQKWTPYMRKVFRQTSEFELVENFVPRLTENIKDFQATIMRNAYDRSLSGPRSVATSRNYPGVENFDYIYIIHKGYVYAAKGSPNGLVQGILHFSYAFPSDERILFAQKSPSGGSDALSDLTLHDPTDSSQYVVVLIREQQNKIIVFRYLYYKGA
>NZ_AP019860.1|WP_151969992.1|5840056_5840758_+|hypothetical-protein
MKKLNVMDLGLGNYTQVLRLQKEIMEKRARGEVEDTLILVEHPTVITLGVKANEQSIKVTKEYLAENGIEVHEILRGGAAFLHSPGQIVGYPIFLLEANERRAYLETIQQMMMDLTEEHKIPAVLHPNKDYIGVWYEVESGAYKKIGAVGMRFVNRNDQYVTLHGFALNVNNDSSIVEKLIFMCGCPSETCISWKEITQKTFDLSQIKENIIHKLAKDLHYNTVYTNKKNNHH
>NZ_AP019860.1|WP_151969993.1|5840810_5841701_+|lipoyl-synthase
MNKLYNKPEWLKIKIEHDPKFDDVRKTLSENSLVTVCEEAHCPNINECWSSGTATFMVLGDTCTRGCRFCNVKSGRYGANIDPMEPMKIAESVKKWGLDYIVITSVDRDDLPDQGSEHFAKVITTVHQQSPEVLIEVLVPDFRGDVKCVETVVQARPNVFAHNVETIERLQGRVRDNRATYEQSLMVLEYAKKQGLYTKSSLMVGLGETEEEIAQTMDDLRRIDVDFLTLGQYLRPSLKHLEVVEYVHPDQFEHYKKIGLEKGFRYIAAGPFVRSSYKAGEFFIKSIVKENGNDGA
>NZ_AP019860.1|WP_173013472.1|5841687_5841924_+|hypothetical-protein
MMELKFPDLGNGISEGQVIKWLAKEGEVVQKSQNVLYVETFKTMIEIPATSTGKIRQQKCKIGDMVKAGDVIAVIDAD
>NZ_AP019860.1|WP_151969995.1|5842040_5843030_-|hypothetical-protein
MLFTSTKKSIIFAICLCTLISLTAEKMEDYQFQGGISYSNEGSFVWANVSHDGDDIKEASVTVNDIQLVYQEQHGMYTAKLHDVQGGSLVKVIAKSAKGEVFFHRTAQIPQLATITQLSMRKDHSYSMGWTRTNATLLEATYETLSKNHPQNRGEFTTVVPSDKSTIIIPANNIVNGHAKFSICAFGGDIQLARGEKSSSWFITKAIDSRSHHISHAQHHDVKNEYPGAPLQEVSEWDDKKDGVKIHFRAYDPLQIVQEGKLHLHIKLKNNRVAVAVVVIDGEKVWFEKRIHKSKDKVYTVVLDVSVGAQVVLGTQACKIYAFNYYVAK
>NZ_AP019860.1|WP_151969996.1|5843257_5844310_+|hypothetical-protein
MRLFFFCICTFIFSSVIVADNENCTPQQHNGKPHIIVTHIYARDFLYEEKNVDWESEIRALSSVKRVHRRYGTSIFDGARGVGISAEEGISWPDIRGHRVRFLTKKQLNSPVDEIGIIVSFSFLKSRRYLPYDANLHEKDTWENVLLPSKIDLEVDSWHGKSTIPVPVIGVVADEFLPKPYVITCGFLEILRNWRSEFLYMLKNRKNEPLVLPPAQSIYYTLTESQRMWLQDNEKVVEQIEEKLSIPVFVDFWDNGEAIQCRLVIEPEEEISRKKVKEIDEHLRSYTELRDLPEAMVDFIPVWKWENVEFYRKYDADHFAIYLKNNDQNVLQELKKIGLKIIWFRNDTRY
>NZ_AP019860.1|WP_151969997.1|5844444_5846262_+|hypothetical-protein
MLHILSISFICLTAIQITRAWFPLLYSFAEKIGFYNIPVFVLVVSCIPILGLLLKRFHSYGIVIVGSYLALLRVIIQLFAMNFWIMFVGISLFLVVLPLAVIDIRKSTRANDFVCGLLFAMAIDTTLQTFHHTWDYIWQRDYFSFALTVIIALITVYCVWKRKKQPQQDELLVIPWWISCYLAIQTVLLHNIAFVAASAQCSIFVASVVIIAADIVAIGSLFFPVKISLRVPVVAIIVYSIHCLFTGQFIFPALFAAQLALNFLLRMYLQPVAAHQENNYASYVSTLVVCTLYALTILLYQLHYESPLPFSNIWLFIAPFVAVVVISMDNSQKYTNEKPPLAAIGAMIVAIISVAIFGSLQPQITENVSEKAQFKMVCYNIHEAVNARGVLDPETIAQIMEQNQVHAVLLQEVGRGWPISGMIDLAHWFQNRLRMKLVYAPAASVKFGNAILTNLKITEKGHKMLPQGTGSMGRSYVYVRLQLGKELVYVVNTHLQHKKKNTLVRIQQINELLNNWNLTPHTIIAGDLNSQPNGEEMKLFSKDRWVSAQDITKYDYPFTFQKGKGSEKRIDWILGSKDLSFHDFYIIKSDASDHLPLFTSVKVKK
>NZ_AP019860.1|WP_173013473.1|5846374_5846941_+|hypothetical-protein
MNIGGNFNHGIEIPRSPPKQTSLSDLKEETGKLASEKKLEMKPISEMNMSEKRKLEKLKLRDQEVRTHEQAHVAAGGKYIKSAIHYDYQVGPDGRKYAVGGNVKIDSQPVPNQPQETIAKMQVVRKAALAPAQPSSADHQVAQKASSEEAKARQELAQKKLEEQATEKYSFHQQQGESDSQDNFSIVV
>NZ_AP019860.1|WP_152022042.1|5847161_5847746_+|heme-binding-protein
MFGCTSYERPNYKVIQTYDHFELRHYPAHIVAETQVNASFDKAGNKAFRRLAGFISGANSKQQKIAMTAPVNQQASEGETIAMTAPVNQINIAKDKYMIEFIMPQKYTMETIPQPTNPKVKIRQIPAKIMAVRKYKGSWSQVKYNKNKEMLLTNVQQAKLEANGNPIFARYNSPFTIWFLRENEVLVEIKNAAR
>NZ_AP019860.1|WP_173013474.1|5847813_5848248_-|hypothetical-protein
MNKIYVVVMALFVVCSYGFCDAIYTGSGYYLRAEYGGGGKVDAKAKKRGEWEEWQLIPQEDGSYAIKSSGGFYLSAKNSGGGKVDARHRKIGLSQKWRRQSVGGGYFTFKTSKGYYLQAKNNGGGKVDARSKKMSEGAKWKILK
>NZ_AP019860.1|WP_151970000.1|5848358_5853134_-|protein-kinase
MDEDRIKKIWKDVIPEEELENSNPGSTYKSVKLEKGTIASLELPFITLTSDAAQQENSDEEKDTRSTASGGKNHFATALTLKYEDDTRRIGGYATTTLNYELLDEIARGGMGVVFKGKQLSLRREVAIKKIKSAKEDVANKDKFISESLVTAYLDHPNIVPVYDLGQNEKEEVFLAMKLVGGTEWKSLLNPKTAQDKELAQKYNIEKHLGILINVCNAIAYAHSKKIVHNDLKPSNVMVGEFGEVLVMDWGIAVDIRDSDERGDETMTMHRSLVKSPMGTPHYMPWELAEGAGTNIGPWTDVYLLGGILYHILMRTPPHRGGTLEALVSAITGKLPAFPKAIPKELQQICSKALSKEISQRYQSVSDFQKALQGYLQHSESLVISAKARNILKECLQVEQKLLLEKERNKLYAKFAQAVSGFEQALELWQENEEAMRGQHAARLAYANVALINEDFGLADAQIAPVTETGEIKQLKVKIAEARIKKIQMEQATKKLRITVYAALIFIIAGLTVGFLLVNRAQQELAKEKKTVEQQKDAIQQQKDAITKQLAEIGLKKAEEAYQKSLLEDEEININSYMKQERAYRECGAYAGKALDYLRELKDFDDLQNKGRAFVKLALQQRKEVWHSPSYGHSGSPGSLTFTHDDQAIVSIYDDNKLQLWNVKTGKEVAQFKKYMRNALTIAFSADGTILACGMGEFDEEQEEYRDCQVKLWNVKTGREVLRFTKHKMPVKHVVFSEDGNTIFSSSGNNTARLWNINTGKQLSHIQHADTINSAAFHHNNKILATASSDKTVKLWNIQTGKEILQLKGHSDMVTSIAFAKGSKILASASEDQTIRLWDTTSGQELSKIVAHSDAINSIKFNHDGEILASASRDHTIKLWDLQTRKSFLSLTGHTATVNAIAFSHNDQILASASEDHTIRLWNTVSGKELSQIAGHTAAIHSTAFSHDGEILASASRDHTVKLWDTKTGKKLFHLKGHDAAVNAVAFSRHNILASASEDRTIKFWNTTTGQQLSQITAHNATIHAIAFGHDGKTLASGSEDHTIKLWEVETGEELLHLQGHSDTVNAVAFSNDGKFFASASSDKTVRLWDSITGKQLSVFTAHTGKVYSVAFSPNSKMLASSSGDEYGNDCAIKLWECETRKEIAHFVGHDYTVYSVAFHPGGQILASGSYDNTVRLWNIQTGKQISKITGHSDVVYTVAFSPNGSRLASGSGDQSLKVWDVNITNSFLRITPSPHKVNTVAFHSDSKIIASGSWDGKIALWDTTTGKNVANFVGHTGKVHSLAFSHSGKILASGAGIYDDDNEEYQDCSVRLWDVDKGKELIRCNGHNEPIKSVIFSRDGQIVASGSWDNTVRLWDTTTGKELLMLNGYSRNIRSIAFSPQNKMIASSWDGAIRIWNITTGKEIMTLHGHTDDISCLVFHPNGKLLASGANDNTIRLWEIATGKLVSILTGHTSYVLSIAFSPDGNTLASGSWDKTIRLWNVTTGKEFSKLVGHSQSVNSVAFSPNGKILGSGSWDQSVRLWNIEKNKTLPWFDSMGNDKRDSFYSTLQKTPQELTKRLFGLQVNQNMELEPYVYQQRLWQPLKVDFLDK

Crispr_ID: NZ_AP019860_26

• CRISPR_ID: NZ_AP019860_26
• CRISPR_location: 5872062-5872225
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_26

Consensus_repeat	Method
ATAGCAGACTCTGGACAAGTGGTCGCAAATGAGACGATAGCTAGTTCTTTTGG	CRISPRCasFinder

spacers of NZ_AP019860_26

>26.1|5872115|58|NZ_AP019860|CRISPRCasFinder
CAGAGGTGTGGAAGAGCCTTTTTCGAAAATAGAGATGGATTCAAATGCGAATGTAACC

CRISPR arrays and Neighbor proteins around NZ_AP019860_26

CRISPR arrays

The CRISPR arrays of NZ_AP019860_26

>merge|NZ_AP019860|26|5872062-5872225|CRISPRCasFinder
ATAGCAGACTCTGGACAAGTGGTCGCAAATGAGACGATAGCTAGTTCTTTTGGCAGAGGTGTGGAAGAGCCTTTTTCGAAAATAGAGATGGATTCAAATGCGAATGTAACCATAGCAGACTCTGGACAAGTGGTCGCAAATGAGACGATAGCCAGTTCTTTTGG

>NZ_AP019860|26|22|5872062-5872225|CRISPRCasFinder
ATAGCAGACTCTGGACAAGTGGTCGCAAATGAGACGATAGCTAGTTCTTTTGG	CAGAGGTGTGGAAGAGCCTTTTTCGAAAATAGAGATGGATTCAAATGCGAATGTAACC
ATAGCAGACTCTGGACAAGTGGTCGCAAATGAGACGATAGCCAGTTCTTTTGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_152022044.1|5888270_5888465_+|hypothetical-protein	unknown	unknown	gnl|CDD|236877
NZ_AP019860.1|WP_151970009.1|5865632_5869463_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970017.1|5879040_5880072_-|Holliday-junction-branch-migration-DNA-helicase-RuvB	unknown	unknown	gnl|CDD|234619
NZ_AP019860.1|WP_151970005.1|5857797_5860107_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970022.1|5888631_5890392_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970004.1|5856658_5857660_-|VWA-domain-containing-protein	unknown	unknown	gnl|CDD|238738
NZ_AP019860.1|WP_151970008.1|5865012_5865438_+|DUF4149-domain-containing-protein	unknown	unknown	gnl|CDD|372664
NZ_AP019860.1|WP_151970019.1|5882986_5883961_-|hypothetical-protein	unknown	unknown	gnl|CDD|379051
NZ_AP019860.1|WP_151970007.1|5862349_5864734_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970015.1|5876395_5877922_-|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_AP019860.1|WP_151970010.1|5869599_5870193_+|pentapeptide-repeat-containing-protein	unknown	unknown	gnl|CDD|224276
NZ_AP019860.1|WP_151970016.1|5878081_5878990_+|sulfotransferase-domain-containing-protein	unknown	unknown	gnl|CDD|366246
NZ_AP019860.1|WP_152022043.1|5861046_5862333_+|glutamate-5-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|234685
NZ_AP019860.1|WP_151970006.1|5860221_5861007_+|glutamate-5-kinase	unknown	unknown	gnl|CDD|239775
NZ_AP019860.1|WP_173013475.1|5884941_5887707_-|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|349398
NZ_AP019860.1|WP_151970011.1|5870395_5870920_-|dual-specificity-protein-phosphatase-family-protein	unknown	unknown	gnl|CDD|350348
NZ_AP019860.1|WP_151970018.1|5880352_5882917_-|hypothetical-protein	unknown	unknown	gnl|CDD|274009
NZ_AP019860.1|WP_151970020.1|5883963_5884938_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|225076
NZ_AP019860.1|WP_151970014.1|5875700_5876306_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970012.1|5871095_5871479_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_152022044.1|5888270_5888465_+|hypothetical-protein	gnl|CDD|236877	PRK11192, PRK11192, ATP-dependent RNA helicase SrmB; Provisional.	1.81248e-06
NZ_AP019860.1|WP_151970009.1|5865632_5869463_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	7.4273e-98
NZ_AP019860.1|WP_151970017.1|5879040_5880072_-|Holliday-junction-branch-migration-DNA-helicase-RuvB	gnl|CDD|234619	PRK00080, ruvB, Holliday junction branch migration DNA helicase RuvB.	0
NZ_AP019860.1|WP_151970005.1|5857797_5860107_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.89038e-77
NZ_AP019860.1|WP_151970004.1|5856658_5857660_-|VWA-domain-containing-protein	gnl|CDD|238738	cd01461, vWA_interalpha_trypsin_inhibitor, vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to the extracellular matrix by binding to hyaluronic acid. The heavy chains carry the VWA domain with a conserved MIDAS motif. Although the exact role of the VWA domains remains unknown, it has been speculated to be involved in mediating protein-protein interactions with the components of the extracellular matrix.	8.0448e-20
NZ_AP019860.1|WP_151970008.1|5865012_5865438_+|DUF4149-domain-containing-protein	gnl|CDD|372664	pfam13664, DUF4149, Domain of unknown function (DUF4149).	1.99176e-05
NZ_AP019860.1|WP_151970019.1|5882986_5883961_-|hypothetical-protein	gnl|CDD|379051	pfam13177, DNA_pol3_delta2, DNA polymerase III, delta subunit. DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.	8.56144e-38
NZ_AP019860.1|WP_151970007.1|5862349_5864734_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.30559e-100
NZ_AP019860.1|WP_151970015.1|5876395_5877922_-|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.84993e-10
NZ_AP019860.1|WP_151970010.1|5869599_5870193_+|pentapeptide-repeat-containing-protein	gnl|CDD|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	8.27178e-11
NZ_AP019860.1|WP_151970016.1|5878081_5878990_+|sulfotransferase-domain-containing-protein	gnl|CDD|366246	pfam00685, Sulfotransfer_1, Sulfotransferase domain.	6.83541e-14
NZ_AP019860.1|WP_152022043.1|5861046_5862333_+|glutamate-5-semialdehyde-dehydrogenase	gnl|CDD|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	0
NZ_AP019860.1|WP_151970006.1|5860221_5861007_+|glutamate-5-kinase	gnl|CDD|239775	cd04242, AAK_G5K_ProB, AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine) biosynthesis. G5K is subject to feedback allosteric inhibition by proline or ornithine. In microorganisms and plants, proline plays an important role as an osmoprotectant and, in mammals, ornithine biosynthesis is crucial for proper ammonia detoxification, since a G5K mutation has been shown to cause human hyperammonaemia. Microbial G5K generally consists of two domains: a catalytic G5K domain and one PUA (pseudo uridine synthases and archaeosine-specific transglycosylases) domain, and some lack the PUA domain. G5K requires free Mg for activity, it is tetrameric, and it aggregates to higher forms in a proline-dependent way. G5K lacking the PUA domain remains tetrameric, active, and proline-inhibitable, but the Mg requirement and the proline-triggered aggregation are greatly diminished and abolished, respectively, and more proline is needed for inhibition. Although plant and animal G5Ks are part of a bifunctional polypeptide, delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR; ProA); bacterial and yeast G5Ks are monofunctional single-polypeptide enzymes. In this CD, all three domain architectures are present: G5K, G5K+PUA, and G5K+G5PR.	2.50292e-90
NZ_AP019860.1|WP_173013475.1|5884941_5887707_-|FHA-domain-containing-protein	gnl|CDD|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	1.99735e-26
NZ_AP019860.1|WP_151970011.1|5870395_5870920_-|dual-specificity-protein-phosphatase-family-protein	gnl|CDD|350348	cd14498, DSP, dual-specificity phosphatase domain. The dual-specificity phosphatase domain is found in typical and atypical dual-specificity phosphatases (DUSPs), which function as protein-serine/threonine phosphatases (EC 3.1.3.16) and protein-tyrosine-phosphatases (EC 3.1.3.48). Typical DUSPs, also called mitogen-activated protein kinase (MAPK) phosphatases (MKPs), deactivate MAPKs by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. All MKPs contain an N-terminal Cdc25/rhodanese-like domain, which is responsible for MAPK-binding, and a C-terminal catalytic dual specificity phosphatase domain. Atypical DUSPs contain the catalytic dual specificity phosphatase domain but lack the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. Also included in this family are dual specificity phosphatase-like domains of catalytically inactive members such as serine/threonine/tyrosine-interacting protein (STYX) and serine/threonine/tyrosine interacting like 1 (STYXL1), as well as active phosphatases with substrates that are not phosphoproteins such as PTP localized to the mitochondrion 1 (PTPMT1), which is a lipid phosphatase, and laforin, which is a glycogen phosphatase.	4.64811e-09
NZ_AP019860.1|WP_151970018.1|5880352_5882917_-|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	3.22492e-08
NZ_AP019860.1|WP_151970020.1|5883963_5884938_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	3.76325e-06

Protein sequences

>NZ_AP019860.1|WP_151970012.1|5871095_5871479_-|hypothetical-protein
MVAHFHIPLNLPHAGTIAQRIQTLVSRETKDNEQLQEMQKISDKLMLLLLPYKRYGENPPPQQAQKVREEAAQLARNLVDEIECSDCGADRLGQCIRNLFECLELGEEGAIISLRAGENPDSAQRPI
>NZ_AP019860.1|WP_151970011.1|5870395_5870920_-|dual-specificity-protein-phosphatase-family-protein
MELFITSLQEAKELLEQKPNFYRVVSISSPLDPVDDLENAKEVLYLYFDDIDKSRKKSALIQLKTVSKEDCQKAIEFLNSDGPLLIHCHHGKSRSTAIALGFLLQKSNNYQQAIEELLRLKPWAAPNEYIVELMCSIFNRSNQYSQILSYFYQKRKEHLSKFYKRPHWKFGWIT
>NZ_AP019860.1|WP_151970010.1|5869599_5870193_+|pentapeptide-repeat-containing-protein
MFFSQREYYEETFEDIEVSEQEIRSIEFEDCNFVQCDFSEKIFWECKFSHCHFTQCNLSLMKVAQSTYCDVVFEDSKVMGVNWSEISLPKIPLACPIKFLRCNISNSSFLGMNLPKTSIKDCVAKDVDFREANLCESNLTHTDFSESHFMQTNLSKCDFSHAKNYRIDIAMNKIEKAKFSLPEALSLLYLLDIEIDN
>NZ_AP019860.1|WP_151970009.1|5865632_5869463_-|protein-kinase
MQNQYLRHYQIIRKLGQGGMAIVYLARDTKINRYVAIKMMNDEQTSHERFVREAKYSASLHHPNIVKIYDFFVVQNIPCIVMEYVEGHTLKEYLNTHSLSVQQKVKIFDQILHAIHYAHQCKIIHRDLKPSNIMITKDGSLRIMDFGLAKKLSHNEKNLTKSQQVIGSLFYMSPEQVQAQKNMNHLVDIYALGAILYEMLTAQKVFDGPTPINIFYKIVHEKPRLPSKINPQVPSSLDAICINALQKNKNHRYQSADLFSHDIQAWLQGKSTRASSLKNFIAYYKNGLVVFLSILILTPIVFLVFTKQTVQIPSSQITFTLQNKIDQWIYNGLYEKAHEELLASKINAREYREYQLLIYAKSQRFSKFEILIKEQEKPFSTLVSMALGEYHFLKNNYEKAFPLLKTVATSAKSKGVHKKYSFYYLGRIYFQKQQYQLALENFRLCQEIRSKWPFLAHQMLQLFIGKNYFYLNKPTLAIESFQSVQSQLQHNAEIYFYTAKSYILLNDYKRAHRNLQKSIELDYENADYRISLGKLLVKQKKYKEAGDVFLQVRALHPLNTKALKEFTAIANKDINLLEERYLALLHDLENWRYVPTENIRHQLYSIRDQHKNDYYTLQRLLSIQTHRKSILHLVDKMSSKNKSVSHAARLGILTMRHTPQVLQILQQKKYHKIAQDVKKMAIRERYSATCYVMAQACLYPYSNIIDELDVKNVEKILCDRQVDIWHRYIAARSLLLLYQFEKVELFRRKNEDQNLQIVCSRALQDFDIVTVRKPQTIAFASHDPNIVMIAAGARSFFKIDMSKLPPSLLDNTTVAMEIAMNLKKKYAAPAARIFAKYTDEKYPPHIRKIAFHYLGRIIGRAKPLQKQYAGLWLKALQQLEKLPQELQITILQKLPSILDVPEGTMKNILYTAHHPYVKIAAIDRMLLENTSDGILRKYYRDEKNNPIVRLYIFYKIFRKGMIKLRLENPEFLIKSQNNFLRSYGYSMYAACGGEVLDWLEKEQYSNIQALILKNVGMMTLPIARDRRKPVDQRMAILKRYFSAKNTNLRTYAYGGYAFLANLQQLNELIEQVRGKDFYARKGISLAINRRIEMELLEKSGALKLISVFQGSRVVGEVPFLDEFYKNIKDKNYRRRYKAWFLKINKLKYVDVDDIFRQAMVAKEDGNYERAIKLMQQATALEQKVIFYVELADLYWKHTKKIPSNIINTLQKLTRAKVIVASSYSLLSQIPHPQIDKVLKQSILSLTPYGKERKKAWRNMMLYYKKRGKKSLLVPGE
>NZ_AP019860.1|WP_151970008.1|5865012_5865438_+|DUF4149-domain-containing-protein
MTYLQDISMITIAFVFGGMVFFSFVMAPLIFIKLEGQIAAHFIRQVFPVYYIVMAISCFAISLLTFSIHLYVSLATLILALIFIWLRFYLVPTVNKYRDLQKEGDNDAGKKFDFLHRLSVIINFIQIVTIATVFFVVLYTK
>NZ_AP019860.1|WP_151970007.1|5862349_5864734_-|tetratricopeptide-repeat-protein
MKTRKFGRYVLEKELGRGGMGVVYQAYDTYLKRFVALKLILQGDVKRFLKESEMMAQLKHENIIQFYEFSNEPQPFFTMEYVEGTTLSQGIKERKIEPGLLVEIMIQVCKGLVAAHKKNIIHRDLKPSNILVTSSGRAKIMDFGLAKRLEQDAQQLSKTGQIVGTVLYMPIEQIEGHVNEKSDIYSLGATMYEALTYRTVFQGATDINIIFQIQNKMPIPLRELNPDISPYLEAICLKCLSRNPNRRYQSAQQLLQELENFKNHRPIIARRYTHIHALRNLMFTHRKLFAVMGLIIAMLVIFSGYMISKERALQQTNNELKLLNSAMIEFVKNIQKSSHSDMLVNPEIIKPLAVVFSQSIHLKTAEEYIFLRGVILGQSVDKKNMRQAIIDYTQTIRQYPKMGANYNNRGAVYVGLEKHDSALKDFDKAIALTPHEAEYYYNRGFVYHELHNYEKALQDYKQAIELNPQYSKAYYSRGNLYKFRREYEKAVLEYNKVVALTPNDRKAYYQRGNTYRSLRQYTKAKLDYDKTIRLDTKNPEGYVGRGEVYIQLGKYDKALRDIDTAISLDAKYYDAYIVKAFLYKRLRKYEQAEMNYNKAIAMNPDSGKAYINRGNMYSDWKKYTKAQQDYDKAKMLSPDDPVIYYNHGNLYKRWKKYAEAKKNYDKAIALDATYSEAYANRANIYYAWKDYKKALVDYEKAIILSPKNIQIYSNRGAMYCSLEQYSKAMQDFDKILSIDPKNANAYGNKGIVCYNKKNYRQAIRFWQYALQLAPQEMKFLRTNIKFAKRKMNKK
>NZ_AP019860.1|WP_152022043.1|5861046_5862333_+|glutamate-5-semialdehyde-dehydrogenase
MAFLKTASIEAQQRSNALKRIADELIAKTPQILAANEKDLEATKPLVEKGEISEALFKRLKLSESKIRDMAVGVQSVEELANPVGKTLSCLELDRGLELFQITVPIGVICTIFESRPDALIQISSLCIKSANAVILKGGTEAQNSNQILATIVRDALRENNLPVDLVQLIETREDVKNILTMDDLIDLIVPRGSNEFVSFIQKNTNIPVLGHASGICHEYVAQDADLNKAYSICFDAKVQYPAVCNAMETLLVDEAISEQFLPEMAKKYLDAGVELRGDQRVVAVLQAHDIDIKEASEEDWTYEYNDLILSIKIVGDMNEAIDFINRCGSAHTDGIITENKEKALAFITRVDSSSVVWNASTRFSDGYRYGKGAEVGIATGKIHTRGPAGIDSLLTYKYVLVGDGHVVANYSGNDARKFTHRKLEKSW
>NZ_AP019860.1|WP_151970006.1|5860221_5861007_+|glutamate-5-kinase
MSDIKSIKRVVVKIGTSSLFAGDAPNTKMINHLAEDISELQSRGKEIILVSSGAIGFGREKLFLTDSKLSLEMQQATAAIGQNLLIHAYEKAFSSRHKIIAQLLLTHQNFANKNALQSLKNTAEKLIELNTVPIINENDPISAEELDVDGYFSDNDELAALCAIHFKAELLIILTNVSGIFTENPDSSADAKIINDVAQLEKFRNFTEEKSALGSGGVKSKVIAAKKALANDVQVIVCKAGKNVIKNIFRGKIPGSYFKPE
>NZ_AP019860.1|WP_151970005.1|5857797_5860107_-|tetratricopeptide-repeat-protein
MQLLNNRYKFQKVLGQGGMGRVYLCIDTHTEKPVAVKECFINDSTSQMQIRRVKREFYFLHKIDHPNIVKGIERIHLHNRYFIVMEYVAGISLEDFIKQKIDVSLSKKIEIMRQICAAVVELNRNGIIHRDLKPANIILHGEDYCPKILDLGIAKIMNKELTTLTKTGGIIGTPAYMSPEQVRGKVSKNTDVFSLGVIFYQFLSGEEQSPFFSGSPISTVDKILKKKLPSLASIQSINDKRFAVLSHIIDRALIKRSATRLDSTAKMLDAMNNLDRNIAIIYGHKLISLIADHKLIATVLLSTTLLLFMLITPNIKKSTDKVAQYMQKILHFDGIKNSEEVIKLANAVLKLNPQFAKAYLYRGRSYQESGNYDLAEKDYDKAIALAPKSQEGYYNRGGLFCDQGRYELSEKDLNTALRLNENYTNAYQRRGVLYQEQKKYNLAIKDFSKAIALDPQNIQTYIRRSKLYDSLGKPVLAIKDCSKIIEINPQDSAGYVQRGNMYFMQKKYSLAEKDYEKTIELNPYEVGACANINNLYIEQGRYDFAVKKYTRRIEKNPRDYITYHNRGLLYCMKGKYRLAERDYTKAIEINPRYAFGYCQRANLYFIMQKYDLAARDYTAAIKTYPRYKGFYNIRSNLYRNQGRYDLVEKDYTTIIQLNPKDPASYQTRGDLYQELQKYDLALKDYHKAIQLSRKHIGAYFRRAGIYERLQKYHLALEDYTTVITINPNNANAYYQRGKVQHALGKHAQAQQDEDKAFALNPRLKNQLQK
>NZ_AP019860.1|WP_151970004.1|5856658_5857660_-|VWA-domain-containing-protein
MKRRKKIMSSFISLLLHIIVIYLFVFFSPPQKKRTSPVYEVSLVRIKRVAPQKQRKKAGGASAANTAQNKVQTQEVTHDENWFPVAAAQEKFVAPTLNKQKPSKQSKFKMSGERLTAPQGNIAKILQKVRARKTGNGSGRGNGDGIGNGNAFFDVSVEADNVVYVIDISTSMNVYLAAQQLKQSYHKLTDQHTFNIIAFAGEVYSWKDKLQKATQENKQDADKWLQNLGGEMMTNLYKALKVTYEMIDEDTTIYLVTDGYTVKLRSLLNHIGSWQKIGVYTSLNIIAVGQRINELYLQTLAKQNNGTYVRKQTSVWGERRSRTQFGKRSRSRK
>NZ_AP019860.1|WP_151970014.1|5875700_5876306_+|hypothetical-protein
MHLFVDMLATHSPKAHYYRYLNQLLSSVAQKRYREMEKSIEHALRLDPGNTKYLFEKACILMGQGATQSALKILQKIAVSPPGDYIFQRDLARLQIAEIYVYDLQVSEEKKLAVVKKLVRMQNSNIFQQDMVYILKVGRLYAKLGEWKIARQIFDYLFFHKYKVMYRVPFAFEFYKDKLNESDEARVKSYLQQFTFDYSKK
>NZ_AP019860.1|WP_151970015.1|5876395_5877922_-|STAS-domain-containing-protein
MLRISIQSLQSDIHLMVLNGNIDENTIGALQDNFTRLFSENKNKIICDMKNVKHISAPVLKTFLENITTARNRGGDIKLVSLPPDLQGILRYAGFNDDSALCTDIQTAIQQLQQPSYPSDHVEDPFGATIQTSQSPLKPASDIYAPTIQNNQSPLQRSSSISPMDDPYGATIQMTGSPLQNIKPSQDKADDPYEATIQMTDSPLENRLKAKEEKTLQADKSPLSSSSSSTKPSESAPKKKSRRTKASAPKKKAPPAASQPTSTPSQPAPAASPPPPAPTSPPQVPQESAAKDQIQEVVETELKRKSTIRFYNRMYPFCIFPLKVIFSQQKIQKIVHKKIAQVEGKKDVVVSKEKPIVEVVPHFPGCLIVPSRKKVDVTPEISQANFSVTPLAESKNQKGYVEIYYNGEVIDTVEELKYHVEKQTIAKFALYMSIISPVISTSLDAFQIDFNEKLPMAIEWLSKLTQLFGGKTGFGLALAGVFLFISIVFYFLKRPREANPIENILPVD
>NZ_AP019860.1|WP_151970016.1|5878081_5878990_+|sulfotransferase-domain-containing-protein
MRKIVFYPETTLQDLDAGTVVMYPIDKRNLYYVVPSFLIIGAQKCGTRELHTWLSMHPNLRASDKELHFFNEVIDIEQEWIRYVLQPCFMHSRGKKHFDKHRFYTFEKSPAYFNDLNYQTPTAEIVKQMMPSAKLVLLLRNPADRAYSAYQMGKKSTRFREASKSSQQDFTTLIKRKMKVVENKPQEQLVRLGYYSLYLQRWLDVFPRENLFVIFLEHFQEEPLVVMKDLLEFLELPPLDYAPLIEKNFRGLWVVKGQYSKGNRKPYKPMSKKARTILDEHYAPWNEKLKELLPECDIPWMS
>NZ_AP019860.1|WP_151970017.1|5879040_5880072_-|Holliday-junction-branch-migration-DNA-helicase-RuvB
MEEDRSLSKNELEEDHELEASLRPLSFDQFVGQTQVISNLQTYIKAATLREEVLDHVLLSGPPGLGKTTLARIISRELGAQITITSGPVLKIAGDLAGILTNLAHGDILFIDEIHRMYPAVEEFLYSAMEDFSIDIMIDQGPSARSINLKLKPFTLIGATTREGLLTAPFRARFLIHEKMSLYPVDDLFKIIQRSAKILNCSITDQGAMMIASRCRGTPRVANRFLRRIRDVAQVHTEDGVVDDKVAAQGLAMLGVDESGLDKTDRRILQTIIDYGGGPVGLKTLAIAVGEEDDSIESVYEPFLIQEGFLQKTSRGRKVTMKAYDAMGVKTQRQDSLFDGFDS
>NZ_AP019860.1|WP_151970018.1|5880352_5882917_-|hypothetical-protein
MIKQIAIIFSLLLVFCYAESKRLYISSIEVSAKKPNGKSWDFTGKKPDVRIEVLQQKNGKWKKTFTSALFKNTTNIDQVINTNIDVDHGSKVKIKVVDVDSFQNDVIGEYEVTVTDEKTHTVNFFSVKSLSYFFSPYKTFLEHQNALKKKASQNAQVESLRKQIAELRAENERLQLQQQSSSSSDDKWKQQYEAKLRDYNTLLSEKSRWQQQSANWKRQYEDKQREYNALQSQQPQQQNTTKWQTLYQEKSQEYNTLQSEKSRWQQQSANWKRQYEDKERQYNALQSQKSHWQQQSTKWKQQYEDKLREYNTVQNEKSRWKRQYEDLKKSSLANNNTTSNNTTASNNNTTNNSDTNTSRTITAAEKQARTKLDSIFRWAKYANGNPNKLMNYYKQAQPFADVLAKYPAQHKEHLEKYRALQKNAEEAQAAKIAKDINYELRKAKYYLDKNNDWIKYYRDNPQQMQKLSDTDAQGIVQQFNNNIELGNEALQKLEKKFGTHAIIEAYKKQWLTSQKEVQTFTNSLSNSSTINNLQKRLAELQKSLNKQINGYKSPHFSPLSFAHYADELQRLHTQSQKDLGAAHNVSQEISKALFLAKKWTVIAYCDQGILARKNNNKYFMKQSFDNAQKIVGNNKELQQIFTEKTASSSNIGLADAELRKVKEKLLQRIAAESQRLSQDFNSYDSHFEHIRPKRQQILDSLEYEKGKALSNAQFTTLQWSKNGWYLQHDGTFYYTWDASLWKRFRQIELDHYKIFRDVRSKILQKYNIKDTEGRVDWHFPGFHDVKFIAVVEKTATYVAKKNVRDAYGRVIAQVDQDPIQVVNVQIMGIKSKYFTLWCDNDSHRNLQTDDLWNK
>NZ_AP019860.1|WP_151970019.1|5882986_5883961_-|hypothetical-protein
MESTLSATEIIHYFQESVKHEHIFHASLFMGSDRFLLENTLQQVIEKIFSPETENSNIRQKVAEKIHPDVMEISAEDKKNISIDKIRKVIENAVIKPWEAKYRIFVIYNIERMSIEAANSLLKILEEPPGHALFLLTAENIYSVPDTILSRCQMFKLHSLGIKNTCETLVNTHQIPIHRAQVAAQLSDGNLQSALSILENDWQVRDSLIQIPLRNRDPISISEAIMSFCAKGEEGRQQTKKWIAFLCSVVRDMMLVKLAGEQINTQIINSDFSKELQRATVNYTHYEITTFLDFLLQCLHMTERNVSVALIWENICMFPHKNER
>NZ_AP019860.1|WP_151970020.1|5883963_5884938_-|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MRRFSTVKGITLIELMVVMAIISIVLGASSAFFTQFNKRLAVQGAAFEIRNVLRSCKNYAAESQNKSTVRVVEDAVILQGSRLLGCWHLEKINQSTSDGFGGQISIEGGEIVPGKVGSAVSLKKIGQVNCGSVQALGLNNGFIISFWCFFYTGQTGNRTIFSLGENGSLQLTPQHTIVFNWGEESIQTPESIPLFEWVQLKIRCDGEKSSIFVNNIEEKSLTFTDFIPIEHYDAELIFAEDAQFKLDEIVVETLVELERYTLPENIVFGPRTTPIVFDEAGKLHPLYHQGNASITVIEQGTEKQFTVRASLMGQLKIEEKTEEQ
>NZ_AP019860.1|WP_173013475.1|5884941_5887707_-|FHA-domain-containing-protein
MKLTFKNRGEEQSHTLGKEPTTIGRSENNVIHLDDNSCSRNHCIIEYRDKSYQIVDLRSYNGIKVNGEKVTSHTLGHGDVITVGKTVMKVIDNFLFASDCSITATHARKIQNESFFTELTKWREIPYATHFVVGLLVLFSLSLFVRVRENFDYYSHSVAKYKEILAQDLETEVAIKKFEEIVEVVPGTSLAKAIQLTIERLKQKETYFANANEAINSVRKAYETGSYSPQKYMYVLEDLNKIYSEPEIATVVKAELVKAKNDYEAEIASVFEGVKSSAQLKLEQGNFQAALKYYKNFSRDYPIKRWQDKVDFEITKTYALQREDWVAFNERIDYLQSKNRFLEARMQVLMKYENYLNTPLANEVQTLLTSLQKNKSQEVVAVTVKKSSYIPNIASFLNKYDVKKLIKNDEWTKIIKELAKLRNETQNSKTRAVIEQYAKDFKSLARLQNNFFASWKDIKDFTIPMANKEAFVRDIQGKTLILGLRGELGTIHFKWGSLPAEAKLSALRKLPFDKSNAFGLASLCMVSGLEDSVHEILIAILDSFPSSKTKVDSFFSRWTGVEIPKPDGFIVFRDLLIHPKEKTLVEYREEVKKFCRSQITNPSRDFDGELQTIHRKINRVSNLEIKDTLLIALGENLFSTRQKLMQKVQNSFDFAAVKYLQQLKQELEKRRKHALELIFDEKTYPADETKGAAAQPDVDKRVAAVREIWDTPSKGIEKLSPRILKSKKIISQIDSFLTKKYPDMYSIAQEDRLESLNSFIDGRLDIKNYAENPREQQRIKDSLKVMQENDNGTNDATSTERRQVAITNAYRHMMGRVAVKINSSLTVAARKHSGHLRANKIFAHVVPGEPEGETPAQRARNAGYTGSGVGENIYMGRTSPQEAHNGWVHSAGHHRNILNPRWRAMGSGQSSNYWTQKFGNQ
>NZ_AP019860.1|WP_152022044.1|5888270_5888465_+|hypothetical-protein
MSKNKAKNKKSTGKSKGKSKKAKKKSRTKKGKKKTKKKRKSKKSMKKKTKKQRKKESEYLEDLD
>NZ_AP019860.1|WP_151970022.1|5888631_5890392_+|hypothetical-protein
MIRAICSLKNTITALALFCMFFGTVVTSETPIPRDIQKIIHKNANKENLIKHVYRKYPKLTEYYSQRQGFFAIEALSEDPVAAIYTMEVFPGYFHYLSTKTSAAEAVKFFKATSHNADFLKAYAQKLRKYQHKPKLLGLLLRSNSQSKEHLITDLEANSAYLASRLVELYSEASPVVRKAIQEKPHAAFFLLETKEDGIAAMDKYGDVVASIATFYKPGERREVLRELQIGGKSFVEAYNKSSIVGWRTAVRFPRLYQRLVETMGIVSALDFLNANGHYLASHVQDPTDEMWITSVTQQVKSLNREGVLNYTFVDSFAFALCSEVEEGKELIARMGDYLPAALIYHYYPRHKTFLCRFLNRYGVAPLKLLFDYAKQEEKRLQIESIIDKYSSNGLLLATYSARRSEAINLLLSDGYDRGKHYLNKFSFDEYGIPSFQGSKDLMPDLVKTTMNYFWYGSKPTWAEFGLAVWDAVDYLHTIYTLGNSKLISQSGKVLFGRATGYTFVKIAEQESKKFTLAKLKKVALNIAWKSFKKVLRKELIHQRFNQLERLTTSNVGRRMTKNFLKTSWKYSYNIALNEFLSYAFD

Crispr_ID: NZ_AP019860_27

• CRISPR_ID: NZ_AP019860_27
• CRISPR_location: 5941212-5941722
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 7 spacers

Consensus repeat of NZ_AP019860_27

Consensus_repeat	Method
TGCCAAAAGAAATAGGGCTACTTTCTTC	CRISPRCasFinder
CCAAAAGAAATAGGNCAACTTTCTTC	CRT
AATAACCGAACTGCCAAAAGAAATAGGACAACTTTCTTCTCTGACT	PILER-CR

spacers of NZ_AP019860_27

>27.1|5941240|41|NZ_AP019860|CRISPRCasFinder
CCTAAAACATCTCTCTTTGCAATTTACACAAATCACAGAGT
>27.2|5941309|41|NZ_AP019860|CRISPRCasFinder
ACTGACTTGTCTCAACTTACAAGGAACGGGAATAACAGAGT
>27.3|5941378|41|NZ_AP019860|CRISPRCasFinder
ACTAACGCATCTAGATTTAAGTAGTACGGACATCGAAAAGT
>27.4|5941447|41|NZ_AP019860|CRISPRCasFinder
TCTCACTCATCTCAATTTGAGTTTTTCAAAAATCACCGAGT
>27.5|5941516|41|NZ_AP019860|CRISPRCasFinder
TTTGGCTATTCTGGATTTGCGAGGTTCTCGAATAAGCAAAC
>27.6|5941585|41|NZ_AP019860|CRISPRCasFinder
TCTTACTCATCTCGATTTGGGGAATACTACGATAACAGAAC
>27.7|5941654|41|NZ_AP019860|CRISPRCasFinder
TCTGACGCATTTATATTTGCGCGGAGCAAATATACGCCATT
>27.8|5941240|43|NZ_AP019860|CRT
CCTAAAACATCTCTCTTTGCAATTTACACAAATCACAGAGTTG
>27.9|5941309|43|NZ_AP019860|CRT
ACTGACTTGTCTCAACTTACAAGGAACGGGAATAACAGAGTTT
>27.10|5941378|43|NZ_AP019860|CRT
ACTAACGCATCTAGATTTAAGTAGTACGGACATCGAAAAGTTG
>27.11|5941447|43|NZ_AP019860|CRT
TCTCACTCATCTCAATTTGAGTTTTTCAAAAATCACCGAGTTA
>27.12|5941516|43|NZ_AP019860|CRT
TTTGGCTATTCTGGATTTGCGAGGTTCTCGAATAAGCAAACTG
>27.13|5941585|43|NZ_AP019860|CRT
TCTTACTCATCTCGATTTGGGGAATACTACGATAACAGAACTG
>27.14|5941654|43|NZ_AP019860|CRT
TCTGACGCATTTATATTTGCGCGGAGCAAATATACGCCATTTG
>27.15|5941523|23|NZ_AP019860|PILER-CR
ATTCTGGATTTGCGAGGTTCTCG
>27.16|5941592|23|NZ_AP019860|PILER-CR
CATCTCGATTTGGGGAATACTAC

CRISPR arrays and Neighbor proteins around NZ_AP019860_27

CRISPR arrays

The CRISPR arrays of NZ_AP019860_27

>merge|NZ_AP019860|27|5941212-5941722|CRISPRCasFinder,CRT,PILER-CR
TGCCAAAAGAAATAGGGCTACTTTCTTCCCTAAAACATCTCTCTTTGCAATTTACACAAATCACAGAGTTGCCAAAAGAAATAGGACTACTTTCTTCACTGACTTGTCTCAACTTACAAGGAACGGGAATAACAGAGTTTCCAAAAGAAATAGAACAACTTTCTTCACTAACGCATCTAGATTTAAGTAGTACGGACATCGAAAAGTTGCCAAAGGAAATAGGACAACTTTCTTCTCTCACTCATCTCAATTTGAGTTTTTCAAAAATCACCGAGTTACCAAAAGAAATAGGGCAACTTTCTTCTTTGGCTATTCTGGATTTGCGAGGTTCTCGAATAAGCAAACTGCCAAAAGAAATAGGACAACTTGCTGCTCTTACTCATCTCGATTTGGGGAATACTACGATAACAGAACTGCCAAAAGAAATAGGACAGCTTTCTTCTCTGACGCATTTATATTTGCGCGGAGCAAATATACGCCATTTGCCAAAAGAAATAGGGCAACTTCTTTC

>NZ_AP019860|27|23|5941212-5941722|CRISPRCasFinder
TGCCAAAAGAAATAGGGCTACTTTCTTC	CCTAAAACATCTCTCTTTGCAATTTACACAAATCACAGAGT
TGCCAAAAGAAATAGGACTACTTTCTTC	ACTGACTTGTCTCAACTTACAAGGAACGGGAATAACAGAGT
TTCCAAAAGAAATAGAACAACTTTCTTC	ACTAACGCATCTAGATTTAAGTAGTACGGACATCGAAAAGT
TGCCAAAGGAAATAGGACAACTTTCTTC	TCTCACTCATCTCAATTTGAGTTTTTCAAAAATCACCGAGT
TACCAAAAGAAATAGGGCAACTTTCTTC	TTTGGCTATTCTGGATTTGCGAGGTTCTCGAATAAGCAAAC
TGCCAAAAGAAATAGGACAACTTGCTGC	TCTTACTCATCTCGATTTGGGGAATACTACGATAACAGAAC
TGCCAAAAGAAATAGGACAGCTTTCTTC	TCTGACGCATTTATATTTGCGCGGAGCAAATATACGCCATT
TGCCAAAAGAAATAGGGCAACTTCTTTC

>NZ_AP019860|27|4|5941214-5941722|CRT
CCAAAAGAAATAGGGCTACTTTCTTC	CCTAAAACATCTCTCTTTGCAATTTACACAAATCACAGAGTTG
CCAAAAGAAATAGGACTACTTTCTTC	ACTGACTTGTCTCAACTTACAAGGAACGGGAATAACAGAGTTT
CCAAAAGAAATAGAACAACTTTCTTC	ACTAACGCATCTAGATTTAAGTAGTACGGACATCGAAAAGTTG
CCAAAGGAAATAGGACAACTTTCTTC	TCTCACTCATCTCAATTTGAGTTTTTCAAAAATCACCGAGTTA
CCAAAAGAAATAGGGCAACTTTCTTC	TTTGGCTATTCTGGATTTGCGAGGTTCTCGAATAAGCAAACTG
CCAAAAGAAATAGGACAACTTGCTGC	TCTTACTCATCTCGATTTGGGGAATACTACGATAACAGAACTG
CCAAAAGAAATAGGACAGCTTTCTTC	TCTGACGCATTTATATTTGCGCGGAGCAAATATACGCCATTTG
CCAAAAGAAATAGGGCAACTTCTTTC

>NZ_AP019860|27|2|5941477-5941660|PILER-CR
AATCACCGAGTTACCAAAAGAAATAGGGCAACTTTCTTCTTTGGCT	ATTCTGGATTTGCGAGGTTCTCG
AATAAGCAAACTGCCAAAAGAAATAGGACAACTTGCTGCTCTTACT	CATCTCGATTTGGGGAATACTAC
GATAACAGAACTGCCAAAAGAAATAGGACAGCTTTCTTCTCTGACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970064.1|5943696_5944104_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970068.1|5948947_5949409_+|type-VI-secretion-system-tube-protein-Hcp	unknown	unknown	gnl|CDD|377536
NZ_AP019860.1|WP_151970059.1|5936529_5937747_+|hypothetical-protein	unknown	unknown	gnl|CDD|224732
NZ_AP019860.1|WP_151970056.1|5932888_5933737_+|ChbG/HpnK-family-deacetylase	unknown	unknown	gnl|CDD|212114
NZ_AP019860.1|WP_151970067.1|5947422_5948904_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|223540
NZ_AP019860.1|WP_151970070.1|5951351_5951690_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013477.1|5943139_5943577_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379326
NZ_AP019860.1|WP_151970062.1|5942421_5942946_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970065.1|5944142_5945909_-|redoxin-domain-containing-protein	unknown	unknown	gnl|CDD|239267
NZ_AP019860.1|WP_151970060.1|5937764_5940680_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970071.1|5951717_5952086_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970053.1|5929251_5930760_+|hypothetical-protein	unknown	unknown	gnl|CDD|319790
NZ_AP019860.1|WP_173013478.1|5949628_5951290_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_173013476.1|5931183_5932773_-|FAD-binding-oxidoreductase	unknown	unknown	gnl|CDD|223354
NZ_AP019860.1|WP_151970066.1|5946652_5947393_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970058.1|5934434_5936438_+|M28-family-peptidase	unknown	unknown	gnl|CDD|349895
NZ_AP019860.1|WP_151970057.1|5933736_5934444_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187625
NZ_AP019860.1|WP_151970052.1|5928306_5928750_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970051.1|5927210_5928245_+|hypothetical-protein	unknown	unknown	gnl|CDD|274357
NZ_AP019860.1|WP_151970054.1|5930788_5931187_+|DUF4440-domain-containing-protein	unknown	unknown	gnl|CDD|178008

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970068.1|5948947_5949409_+|type-VI-secretion-system-tube-protein-Hcp	gnl|CDD|377536	pfam05638, T6SS_HCP, Type VI secretion system effector, Hcp. HCP is a family of proteins which are expressed in up to 1000 copies in Gram-negative bacteria. Together these copies aggregate into a needle-like shaft or tube that will penetrate other bacteria via a puncturing protein attached to its head. Initially Hcp forms a hexameric structure with a central channel of 40 Angstroms. These hexamers pile up one on top of each other forming nanotubes resembling the gp19 tail phage tube.	1.71523e-32
NZ_AP019860.1|WP_151970059.1|5936529_5937747_+|hypothetical-protein	gnl|CDD|224732	COG1819, COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms].	8.73371e-43
NZ_AP019860.1|WP_151970056.1|5932888_5933737_+|ChbG/HpnK-family-deacetylase	gnl|CDD|212114	cd10803, YdjC_EF3048_like, Enterococcus faecalis EF3048 and similar proteins. This subfamily is represented by a putative cellobiose-phosphate cleavage protein EF3048 from Enterococcus faecalis v583. It is similar to Escherichia coli YdjC, a hypothetical protein encoded by the celG gene. EF3048 might function as a homodimer. Each of the monomers consists of a (beta/alpha)-barrel fold that forms an active homodimer. The molecular function of the EF3048 is unclear.	1.6982e-58
NZ_AP019860.1|WP_151970067.1|5947422_5948904_+|AAA-family-ATPase	gnl|CDD|223540	COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones].	4.6085e-41
NZ_AP019860.1|WP_173013477.1|5943139_5943577_-|GNAT-family-N-acetyltransferase	gnl|CDD|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	7.44849e-12
NZ_AP019860.1|WP_151970065.1|5944142_5945909_-|redoxin-domain-containing-protein	gnl|CDD|239267	cd02969, PRX_like1, Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic cysteine found in PRXs, which aligns to the second cysteine in the CXXC motif of TRX. In addition, these proteins do not contain the other two conserved residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF.	1.13296e-20
NZ_AP019860.1|WP_173013478.1|5949628_5951290_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	4.00346e-31
NZ_AP019860.1|WP_151970053.1|5929251_5930760_+|hypothetical-protein	gnl|CDD|319790	cd02603, HAD_sEH-N_like, N-terminal lipase phosphatase domain of human soluble epoxide hydrolase, Escherichia coli YihX/HAD4 alpha-D-glucose 1-phosphate phosphatase, and related domains, may be inactive. This family includes the N-terminal phosphatase domain of human soluble epoxide hydrolase (sEH). sEH is a bifunctional enzyme with two distinct enzyme activities, the C-terminal domain has epoxide hydrolysis activity and the N-terminal domain (Ntermphos), which belongs to this family, has lipid phosphatase activity. The latter prefers mono-phosphate esters, and lysophosphatidic acids (LPAs) are the best natural substrates found to date. In addition this family includes Gallus gallus sEH and Xenopus sEH which appears to lack phosphatase activity, and Escherichia coli YihX/HAD4 which selectively hydrolyzes alpha-Glucose-1-P, phosphatase, has significant phosphatase activity against pyridoxal phosphate, and has low beta phosphoglucomutase activity. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.57985e-14
NZ_AP019860.1|WP_173013476.1|5931183_5932773_-|FAD-binding-oxidoreductase	gnl|CDD|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	1.15396e-35
NZ_AP019860.1|WP_151970058.1|5934434_5936438_+|M28-family-peptidase	gnl|CDD|349895	cd05643, M28_like, M28 Zn-peptidase-like. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They typically have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This protein subfamily conserves some of the metal-coordinating residues of the typically co-catalytic M28 family which might suggest binding of a single metal ion.	3.42784e-52
NZ_AP019860.1|WP_151970057.1|5933736_5934444_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187625	cd05367, SPR-like_SDR_c, sepiapterin reductase (SPR)-like, classical (c) SDRs. Human SPR, a member of the SDR family, catalyzes the NADP-dependent reduction of sepiaptern to 7,8-dihydrobiopterin (BH2). In addition to SPRs, this subgroup also contains Bacillus cereus yueD, a benzil reductase, which catalyzes the stereospecific reduction of benzil to (S)-benzoin. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.3713e-31
NZ_AP019860.1|WP_151970051.1|5927210_5928245_+|hypothetical-protein	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	0.000317197
NZ_AP019860.1|WP_151970054.1|5930788_5931187_+|DUF4440-domain-containing-protein	gnl|CDD|178008	PLN02382, PLN02382, probable sucrose-phosphatase.	3.92942e-14

Protein sequences

>NZ_AP019860.1|WP_151970060.1|5937764_5940680_+|hypothetical-protein
MPNIIQPLLQQHADSEFLFAILQWKAFYADDHEWNNITSHLWQEAQNNNKMAAYYLHKLTSSNDICLSHVKKLSQMASRTLLNSDYSRQVDWEEYLCSLHEMDSLFHETEVHSDFDQSLFCASTLQSVLASFDVTKSILLKYIYRGKLGVDFRDNYIVFVYSQVSELFHCKNSGISTMALCEIMQKCELEDSVYTSIANGEIAVHVIDNEIHIPQTAFSSFLTPQQVKIVEEDDDDDDDIVFIVGETHKDKEPEEYPSIVILPYEFTDRDSAQKKFYSWDEALKRLQIENEDLERFITDGDIQAYTQDGEIIFSCEEIDRWISTLMDDKTIVMPGSSGDVVVEDEEAISLSLPMGLDAPMPKKETYSLDQSLDELQIEAETLEEIVAKGEIETQIVDGELRLVQEDVDKYRQQKQADQTIVMPLDEELVEEEDDEFVPIVTPTANKGKNIALDLSSILEEDGTAITVDLPDVSDELGTGELRMDEEKEVEDTPFESIVIDPQESVIADKTETKQDDVSFKEKEMADSFQRSTTIEPEEPVVDQMPREADFWIDGEDAVMSTIVPPRGGKMPDSEMETTTRARRSRSVAAKKRGKKRSKKRQQLYRKVKKQIGQRLAKKYQKNIGQVTIPTFEGMLSEEAGQPGPIERILAQSQLLLKSIQVTIGLRVLTVINFADNVTEFVAGYITNIYRTWKMTKSIQRRLQRNNPQQQISELQKDLDVMRYQLSRLLTFPEFCLREHKPQQIDSEAQTFALKLVIELRGHLDEMKRDLALLTPKQAAATAQKTAKDFLLSFIPNPLELATPCKDFIILVFFMKYSRKDIEVMYIDLLSSYSDILSLINEEPFYRLEMQDYERKILHRLQREIYCLQDIEKHIEECRLQLQRFIQLLCCVQKFIDPRYWHIEDIFYECKNRNDYMSAKFLLEWEKWVTAQLRKQLKNYHCSTQEKSVMLKEEIYFRRRYKLQRKLTQNFM
>NZ_AP019860.1|WP_151970059.1|5936529_5937747_+|hypothetical-protein
MKILVITLQVSDGNSKGHIHPFITTTQKLISMGHDVFWLSLPKALSQADREQVESLGAQVVVPPPLKEGIIKENKELARLAMDKENNYQAYKSFLLDPVPHQLDGLMELIKDLAPNVVLQDNVLYSAAIACTKLQLPFVSICVGPKIMGKDFEESYLGNLQPIIEPRRAMFESYGVKPNFRLFEYVSPYANIIFATEEFVDKAALPENSFLVGSAVPQGGRGDDVDFPWEDVATDKNIIYAAFGCVLSKMPLADVIDPIFKAADALDAQLILASEHLAASAKDFGRHIVVSYAPQLEILKKAHVFITHGGASSVMESIYFGVPPIVVPLSSDQPVQAQLVEKAGVGFNIAREQWNDEVCLATLQKLLASGNEFAAKCKTLQTTYQNNDGAKNAADIILRFAVTNS
>NZ_AP019860.1|WP_151970058.1|5934434_5936438_+|M28-family-peptidase
MLLDNQTQQTILNELSGERAKDFLTMISRFDRVQCSSGTYECMQMVQGMLSSFGIENIEIERYIADGRKEYWTWPTSLGWEINYGELWMRHPQQMKLADYDEIPVSVVRGSRSADVVAELVDVGTGLEDYEYENVDVHGKIVLAGGPTFSNYAGKVQRQAVIKRGAVGVLLYLNPELSLRPHPGNLIPYYGMWHHADEDEQITFGFCISYRNAVMLKKMIKQDKVTLHARLDAKNQQSTIDQMTCVIPGENLDEEILLVAHLDHYQPGAHDNASGSATLIEIARTLQKLITNKKLPKPQRTIRFLWPTEFQGMAPWLEKNSDIAQRTIAAINCDMVGSNFLKTKSSLNIIKTPFSRPHYINDVVENFARQVANEVVITSPRGESLPLNYRVVPYRGGSDHMFLNDSTTAVPTVMLGEDNPFYHTTQDVPDNLDSTQLKKAMFIALGSVWYLANINSSQSTQLSALVGSKVLRDFSHMSCEVSHLLHSSQPSSLEQNYWEGRNKLQCYLQQNIARVDSVGELDPKNDGVLWREKIKEQLHNVAALYEEQLQDSYAGYCREFTLTAKETKELGEEQQQAQKIIPQRTSLFKGPLAIHLNFALKASGFPEENMKFFDIQFEIVNLIDGKRSIWDIRNAVSAYFGAQSLQDVTQFIKNLEQEKLVVCNMEV
>NZ_AP019860.1|WP_151970057.1|5933736_5934444_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSRVLITGVSAGLGRSLAELYMKKAQVYGVSRRRPGLPQIIHQCIDLADLETVAAKLGMLVKNIDALDVVILNAAHMGVVEDLKDTSVDLLREVMAVNVWSNKIICDTLFQQGIHVAQIIAISSGMAENTCRGGNGYALSKLALNRMMAMYALEQQQTHFCTISPGIIDTAMQEYLQEHKGHEKFPILAQLQQAKDQGMMQSPDHVAQRIVGCQSQFLHYPSGSFVSLKEVEECY
>NZ_AP019860.1|WP_151970056.1|5932888_5933737_+|ChbG/HpnK-family-deacetylase
MLKYLIVNADDLGISPGVSSGILHAHKMGIVTSTTAMVNTAFFRESIQTAMTESVGIGLHITLSYGAPVLPASEVPSLVDKQGNFLSFPIVAPFNAQELQSEIEAQFSLFTEVAGCLPDHIDSHQFMANVHPAAFKTVLNLAKDHQIPIRNPHMFLSKNKLHQFMRSRKTNPLAELDGRIEELQQIYAHFCVAHPDFFEYRFFDTGVTVDNLLEILRNLPTGVTEIMCHPGYSYDLQNDYYLEKRDQEVEVLTNERILQAIQDEGIQLVTFGQIESIHGSKI
>NZ_AP019860.1|WP_173013476.1|5931183_5932773_-|FAD-binding-oxidoreductase
MNPLTKWQGIVGEQNILTSSEHLERYTANVTGIERSIQAVLLPESTEQVQKIVAIANENKTPLYPISSGKNWGLGDRLPVQSGATIVDLKRMNKIHRVDPHHGYAVIEPGVTQKQLYEYLREHNLPFIINITGAGSDTTFVGNAMDRGIGYYGSRVDSMSGLEVVLGNGEVLRTGFGHYLNSKTTYLYPHGVGPSLEGLFFQSNFGIVTKVGMELIPHKDSHAYLSCSLKNPNNLEAFVDILTDLRQRNIVRTTFHISNDHRSEINACPLLYNYFLKEGDDKETSKRKAVELFNSIKSCWSASCGLLGTKSYIKDAYEHTKQALKGIGSVKLWTFSSLKKQQKIAQRLSFLPSYRLKKALLATLEPPLGHSRGIPSNDALNSIFWPLNKIPQDLIEPAQQNCGKLYVLPLVPMSGEAFGEVVQITTNILHDKFGFTPYITMNMAKDKVFESVINIAFHRDDPHQVQKAHNAITEVNRQFVTSGYIPYRVGIQAMSEIISSQDYHWQIVAQLKDILDPNKIISPGRYNLV
>NZ_AP019860.1|WP_151970054.1|5930788_5931187_+|DUF4440-domain-containing-protein
MKEQCYKEICDLHQVFEDWFIGRVPKDDFSYLPQVLSDDFEIVFPGGEIFSRQQIIDIMQKTHGRYAHMPFRIEIKNYRSRSLSDTLHLVTYEEWQVKDNVDEVKVSTAIFRKNDSMPCGVEWLHVHEVYRT
>NZ_AP019860.1|WP_151970053.1|5929251_5930760_+|hypothetical-protein
MKIIALLFTIHLCFTLTAENENWEKVFSAKDIISFAQDDSSSSSKNIWAASTSGKLFFSTDGQSWNTSNVQTEGSISHVVSQENIVFVAFRNKKKDSPLLSLSLDGGKNWNRVGQDIISQLPSSDVIFVTDITISKNSLFVVTRDFRPHNPTSRCFRSDNFGASWSLIHQMSDQHSINTVAVDSNRDVLLGTSSGVLRSKNGHGNWEPLNGGMETNKKTPFVKSISYNHTLGERFAATSAGIFKSHEEGAWQFPKGSNWQNVSSHKSQQAAVALNLIHNYSTSYIVMGTHERSGIGGHFFSTSRLFISNNSQNVTWKEIDLGSLTKKPLYDVIVHERHVIIATSEGVFKSTKSILELGRANSPKTSSAAKVIFFDLGDTLVVSGKKWATGAQQILQQMKSKRLGIISNTGNLSRSQLLELLPQDFSFDSFDENLILLSSEVKIEKPDPQIFQMAIKRAQQINPSLEAQDCLFVTEDMEHLSIARGLGIQTAILVDGKLIRVE
>NZ_AP019860.1|WP_151970052.1|5928306_5928750_-|hypothetical-protein
MQKFIIVLLVMCFSLPCFADRDRRNRNPKEKLRVVFIKKNKKNQEFVCIRMTPIQYRTANARAKVKRRGNIRIVLGPRQIAALHKLLKEEHRWSKVVVRVSAKRLRKLGGLKDRFIIRPKSLFEKKRGKNRGELAIDGEGDYDSILR
>NZ_AP019860.1|WP_151970051.1|5927210_5928245_+|hypothetical-protein
METTNRTKNFVLYCGGENLLLQEEFWFPIDDEYYFEAFPLEPEDLLEESDVISLRLLCELWGKDYDNAFAFDDIAQCANGGLLPYAMTEEDLCFDEGYEYIVYLPQEYTIQINFHDQLQCFLTHPSFPKKIELYCAGDMEFLWPAFRWQEVQNIIRCARYFSHVNGNLNRIFLLLLKMTSTCKEEAQELRQVTRQLCLDIGLFERPTLDTTVAKLTPLSRLKWRKHPQYGWLNNCSGSMRNLECSFVDRLWEKEKLFGALREFFCVMENYEHKPCVMSGHDYREVHQQLQSLCAEEKYLLHLRYIMFFTYEEMGDLLQEKPFTIYEHIQKIIAKIKRHLPLHGQ
>NZ_AP019860.1|WP_151970062.1|5942421_5942946_-|hypothetical-protein
MNFFDNHNVTLIDKLIVFAYRNKGMTPEEVIRAVGCEGHIHYYNGYWTQYGEEIIVTRTEYQRVLQQYNIKEERLRSNVRSLSATNRISSKLFVLEREVQAVIACINRDFSMQLTFNAKNGREVVRISRKGTHTWIHLNEKENDWLEDITELSGWQKNGTYWTKTVQNFIYSAV
>NZ_AP019860.1|WP_173013477.1|5943139_5943577_-|GNAT-family-N-acetyltransferase
MEHIKILKIETESELTYSKVNISHFIHHQLGKYHDSLSAIKKAINYALHRQDGSFLYLATLSSKLVGVLVNYCFENQNEIIYLAVIKEHRKQGIGRMLLQQILKSRYVHLHVHIDNPAKKFYQKMGFVEHSERFFYSYMVFHNMQ
>NZ_AP019860.1|WP_151970064.1|5943696_5944104_+|hypothetical-protein
MNSCNTGVKDGWHFNLFFFDIHTGSLGFLRVEKYQKPILAAGVVFFVSAILHEYLVFVCIHTRMFGYMTAFFMLHYLATVVETAIAKVFQRKHFFPSPIAIALHILWLVATAPLLIKPLLLIFPVDSWQSIVSNF
>NZ_AP019860.1|WP_151970065.1|5944142_5945909_-|redoxin-domain-containing-protein
MKKLFFINVVVLVGIFLYLDMRYNTTQGSQQELTTVEDFALLDHEGKHHELYKYKHFPAVVLFSHGVGCPIVRHSLLSLQDLQKKYPQVAFLMLNANPQDNREDIRQEMQKFQSTIPVLKDPTQLIAQELKITRTGEALVIDPQTWEIVYRGPISDRLGYETQKVGKVQNFVNTALHALLNKQKIDIVPTEVKGCAINMQDNLSIKSQKISYTKDIVPILKNKCLECHQNNGIGPWAMTSYKKIKGWSEMIKEVVLTKRMPPWTADAHYGKFSNDTSLSVQEMRTLVHWINSGSPVDGNEDPLVKLHSKVAKQDWREGEPDVLLKLKPQKVPSTGVMDYIRYKEQVPFEEDTWIRGVDIRPGEREVMHHMIIYIYPPKDPNMDEKKQKKHKIYLCGYAPGSGADMFPENTGVLVKKGSKFEFELHYTTSGRSVVDHSQIAFYLHKEKPQREFKVGAAYDVKIRIPANDPNHEVVASHTFKRDVTLYGLSPHMHYRGKSMTFTAIYPDKSQEILLAVPNYRFDWQTGYTLSQPKTIPKGTKLVCSGAFDNSKYNEYNPDPEKEVRWGEQSWEEMYIGFFLYSPNEVSHR
>NZ_AP019860.1|WP_151970066.1|5946652_5947393_+|hypothetical-protein
MRVQNVIRKSLTEIESNTIYHGCTFYIDHPVPILHNSQFYHCSFRGEKLVVDEIYNCTFIHCNMNELKIKASKRVSFDEGYINEITVEVDSAAFVKMYFNYQGNYILLEPHGFLGKETNVFSQALNLIPRESTQVMCNMEHLQYLAVRCFYRLQSFMESIREENGDIRFYKAQSFMMNLFAVADFSEKLYGSFEEAMCAPRYRKAQDFSSIQPTQGWSSDRMNNLRRFTYTSRSYCFRATTSPLQK
>NZ_AP019860.1|WP_151970067.1|5947422_5948904_+|AAA-family-ATPase
MDLKLSPTQAKCFQNLEKAMDIGNIVVLRGQSGLGKTTLLQVLQKKISGTFIGTPDLLCLQKEKNHLSLPQILDELCTIAFEESNIVLIDDLLSLYDRQSNEFWELILQLICSKAMSMSKKIIFSHTGIATSLVHKRCMYIELEDFQVEDYQFFGEVFFKKHTLDMSKVYQFVPRLNVYQMKMAGQAFHSQEDVHNDDVIDYLLEHHNVNNVFIENVEKVHLEEIKGLDDVLQTLETHVILPLESPLAAELNLKHKKGVLLYGPPGTGKTSIGRVLAHRLKSKFFSVDGRFASNDREFYLQVCKVFEAAKKNAPSIVFIDEADTCWSYGNLYRYLLTELDGIEGARSGTVCIIMTAMDVSNIPPALVRSGRVELWLELELPDEKTRREILEHCIQQHGDFFHDVDLKLLGRNSEGFSGADLRRITDDVKNFYAYDKAHDNETLSVNEYFLKAIKVVKHNKQKQEQAAGNANNNQTAYNSLFSFFEWMNQLPKK
>NZ_AP019860.1|WP_151970068.1|5948947_5949409_+|type-VI-secretion-system-tube-protein-Hcp
MPVNMFLKVEGIKGEAKDEGYEDWVEVLAWSWGCSRNFDKETKEEYYNKQDISITKWYDRTSPIMAFSCSQNTIYPEVILEVNKGDGDKGNFLSYKMKNARVTSCSTGGSGGERRLTENITFEFEEIEWIYHLPKEFHTEEETFVSRSYSSKE
>NZ_AP019860.1|WP_173013478.1|5949628_5951290_-|leucine-rich-repeat-domain-containing-protein
MTKQTIYKQSLKRISNNTNYEGCTFYLDSSKLIHMENCTFRNCSFRNPCTLYIGTLMGDECLFVDCTFSQLEKVFTTPENLAVCAKDIGSYITKMQLNIIKELPGKEILLCENLYHLTLSGGYNRLSEEIGKLKKLTHLELNLQFAALPLEVFELSSLESLKLYDSETGFLPQEITKLKNLRHLNLDDSHFESFPLAVLDLKNLESLSLQRNALTSLPKEIDKLCHLTHLNLESNQLTSIPQEIGKLPLVSLNLRNNKLSRLPQEMDQLEQLQELNVKVNKIEEFPTQICHLPSLETLFFERNKLQSLPPAIQNLKSLRVLSVVHNPITEICSEIGELSSLNYLDLRKTLIQTLPKSFAKLHSLTTLLLSSKNLTSFPRELTKLSSLEILFLGKAIPQFPVEIVEIKNWANLKVLSLSEIPIQKIPQQISSCSSLKTLAICYCEQLQIESLSDIPSLTSLILSSCNIKEIPHNLLHLRKLKKLDLSSNNITTIPHEISKLTELNYLNIRYNNIQTLPDKITLLQNLQSFYYTGNPMEEVSSQVKEFLAQFDSD
>NZ_AP019860.1|WP_151970070.1|5951351_5951690_-|hypothetical-protein
MGKRAYTRYCILLICLIFSGCCHTVGLLTGYQTGNNCEPLTTKLSQKISKEELHVEEYDFTYTNQQGQQQTEKRKNAYRESRPYTYFLRSLYFFTVPIDVMIDIVFFGHLSQ
>NZ_AP019860.1|WP_151970071.1|5951717_5952086_-|hypothetical-protein
MNKTKWGLTFIHVTIAVGFSIAMARHIADHSWDLHARNHAFQATIWLITIHTLGVIITWNAYPQKWAWYTLLITALLFFGGYFAALFVIPQSGAPGINDDILIATFAVIYLAILAVDRKKIL

Crispr_ID: NZ_AP019860_29

• CRISPR_ID: NZ_AP019860_29
• CRISPR_location: 6216287-6216408
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_29

Consensus_repeat	Method
AACTTCTCACTATGAAATTTTTATCTTTTAGG	CRISPRCasFinder

spacers of NZ_AP019860_29

>29.1|6216319|58|NZ_AP019860|CRISPRCasFinder
GCAGAGATAAGCGGGGGAACAGCTTTTTCTCCTATCTTTGCCAGTGCTTCTACAGCAT

CRISPR arrays and Neighbor proteins around NZ_AP019860_29

CRISPR arrays

The CRISPR arrays of NZ_AP019860_29

>merge|NZ_AP019860|29|6216287-6216408|CRISPRCasFinder
AACTTCTCACTATGAAATTTTTATCTTTTAGGGCAGAGATAAGCGGGGGAACAGCTTTTTCTCCTATCTTTGCCAGTGCTTCTACAGCATAACTTCTCACTATGAAATTTTTATCTTTTAGG

>NZ_AP019860|29|25|6216287-6216408|CRISPRCasFinder
AACTTCTCACTATGAAATTTTTATCTTTTAGG	GCAGAGATAAGCGGGGGAACAGCTTTTTCTCCTATCTTTGCCAGTGCTTCTACAGCAT
AACTTCTCACTATGAAATTTTTATCTTTTAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein	unknown	unknown	gnl|CDD|366760
NZ_AP019860.1|WP_151970238.1|6223694_6225851_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970242.1|6233709_6237927_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_173013499.1|6194913_6196548_-|DUF4157-domain-containing-protein	unknown	unknown	gnl|CDD|379338
NZ_AP019860.1|WP_151970235.1|6208072_6215209_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_173013500.1|6203456_6203855_+|response-regulator	unknown	unknown	gnl|CDD|381099
NZ_AP019860.1|WP_151970233.1|6205222_6206125_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NZ_AP019860.1|WP_151970234.1|6206424_6206895_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein	unknown	unknown	gnl|CDD|239819
NZ_AP019860.1|WP_151970239.1|6225875_6227564_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151970231.1|6204419_6204746_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein	unknown	unknown	gnl|CDD|293879
NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase	unknown	unknown	gnl|CDD|226950
NZ_AP019860.1|WP_173013501.1|6203921_6204293_+|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl|CDD|376620
NZ_AP019860.1|WP_151966752.1|6201956_6203207_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970245.1|6241163_6242870_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970232.1|6204916_6205129_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970228.1|6196732_6201625_-|caspase-family-protein	unknown	unknown	gnl|CDD|238121

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein	gnl|CDD|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.37953e-65
NZ_AP019860.1|WP_173013499.1|6194913_6196548_-|DUF4157-domain-containing-protein	gnl|CDD|379338	pfam13699, DUF4157, Domain of unknown function (DUF4157). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteristic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.	1.63297e-05
NZ_AP019860.1|WP_151970235.1|6208072_6215209_+|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	9.60089e-34
NZ_AP019860.1|WP_173013500.1|6203456_6203855_+|response-regulator	gnl|CDD|381099	cd17546, REC_hyHK_CKI1_RcsC-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.37381e-30
NZ_AP019860.1|WP_151970242.1|6233709_6237927_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	1.20629e-39
NZ_AP019860.1|WP_151970245.1|6241163_6242870_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.30936e-52
NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein	gnl|CDD|239819	cd04327, ZnMc_MMP_like_3, Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.	2.70408e-23
NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.96929e-35
NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.09725e-07
NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein	gnl|CDD|293879	cd16269, GBP_C, Guanylate-binding protein, C-terminal domain. Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.	0.00657934
NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase	gnl|CDD|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.22796e-18
NZ_AP019860.1|WP_173013501.1|6203921_6204293_+|membrane-protein-insertion-efficiency-factor-YidD	gnl|CDD|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	2.20447e-08
NZ_AP019860.1|WP_151970228.1|6196732_6201625_-|caspase-family-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.1852e-68

Protein sequences

>NZ_AP019860.1|WP_151970235.1|6208072_6215209_+|HEAT-repeat-domain-containing-protein
MVYGKRYLQNTLIFFVLFNIAFAQSNKETLDEKLKLILKYLKSPDTQLHFSALAELEKIGADAKKIRPELEKALTSADGHSKHAINYAVRRIEFINKKFPSKIFPNASQTKRSPASRISKNVGGLNILGVSNDFRQRLRYGKRHALVIGINKYNKYYSELDGPNYDAGEVASILADRYGFENVTYLCDTIPRNVYRQNELKERNPRRLENRKSYTTKNGSETIVVAPLVTKGVIEKYLTETFAKVGPNDAIFLFYAGHGVPGHIVATPKNKDDDGYISLTKLALNLSEKNAKHTLIVLDCCFGGSLLQDKYKPRLKGYNNSTFQFGTGENIDRVFARRSFQVISAGTGNEVVADKLSASTKYAQLTDSSGHSPFSALFLQALKGLVGRDDGIVLASDLGYYMMTTLTNDKRLDAKQTPRYGSLGGDGDFMFFPAYKVLNPKLLAPLYLSDKMYADFRSSGCEALEKFINTYSRQDQISLTKSALHHISKLLEDEEVGPRKAALNFITEKATKYAKDIKEFNHVVSALTAYFSYNDKKIDLNSFFTLQNQQDETDLYEVINCLGILHKDANKKVVDILEAYNKKLRLQWQELSKDKKKPQSVKDKLEECKELGSLPDESFQKQAHYYYQVVNVYRWLTTIGETELKDYENRMNLFLSNTEDKERKISFNKYKEEFSKDDFKKYFMVRDQYIRKEVLTYLAAKGTDLTILFELLKKLDKREDIKNDIAKDLENVRVRERAFLKIVEEVNNQSEKSKKLLFAFRSWKKKPLFELINKKLSKEDQDIFLPILAEENFNSIYSLMTDKYQNKKDIRSKAAFIISKLNKKERFIAHFFTSINERDLFDKQVAIDILTSKETVTEYSTVTILSLLLKNENKNLRNSAAKTLGEIGEKAYSAVPDLILALKNGDPGLKAHAAEALGGIGEKAYSAVPYLIPLLQNNHADVRSSTAWALGKIGEKVEKAVPDLITLLQDEDEDVKKKVAEALGGIGEKAHSAVPHLITLLQDEDEDVKKKAAEALGGIGEKAHSAVPHLITLLKNSDIQKHAAEALSKIGEKAVPALADALDGDYDVRISVAEALGDIGEKAVKAVPALILALKYEYLYARESAEEALGKIGEKAVPALILALKDQNKNVRRSVAEVLAVIGEAEKTVPALILALKDNDEYVRRTASWGLGKIGEKAYLAVPHLITLLQDKDEDVKNKAAEALGEIGEKAHSAVPHLILLLQDKYSWNRISAAEALDKIGEKSHSTVSHLIPLLQDKEVRADVAEALGKVGEKAVPHLILLLQDKDKEVRADVAEALGKIGEKSHSAVPHLIPLLQDKDKEVRADVAEALGKIGEKAHSAVPHLIPLLQDEDEDVRDKVVEVLGKIGEKAHLAIPHLTPLLQDKDENVRNKVVDTLGNIGKKVRSIVSYIIPLLRDNHASVRNSAVRSLGMMTKSEYPLVQYIIPLLKDKDKWVRKNATETLRKIGEKSICFLIPLLKDDDESVRNAAVIALGKIGESVFSTEECLTSVLEHLSINENWEVRVSAAELLIRMGEKATSSIILLLKDKEVCIEAARALERLGEKAHLVIDFIIYIDTVSISPDELAEIFQSIEKRMITSIIPLLKDRNYKVRCSAAKTLGFMKAYSAIPHLIPLLQDKDYFVRRSAARTLGFMKAYSAVPHLIYLLRDDQCHSMQTDAAEALAEIGEIGEEAHSVVPDLIPLLKDEDLIVRSSAAEALGGIGEKAYLAVPHLIPLLQDRDEDVRNSAAWALGKIEKKAHSSVPHLIPLLKDKDKKVRVDATKILGRIGAHSAVPHLIPLLQDEDKEVRAYAAWALGKIGEKAHSAVPHLIPLLENKDKEVRAYAAWAFGRIGKKAYSAVPYLIPLLQDEDKDVRIDAAEALGEIGGKAEKATSDLIVALKDPDKYVRYSAAEALGKIGEKAHSAVPHLIPLLKDSYTQEVAAEALGKIGKKAEEAVQHLIPLQNDISMALVEKVLEKIRGNIISTLIFHLKNKSLNTRQQATEALGKIGGKAHSAVPHLIPLLKDSYTQQVAAEALGKIGEKAYSAVPYLTLLLQDEDKEVRIEAAKALGGIGGKAEKATSDLIVALKDPDKYVRYSAAEALGKIGEKAHSAVPHLIPLLKDSYTQEVATEALGKIGKKAEEAVQHLIPLLKDSYTQEVAAEVLGKIGEKAHLAVPHLIPLLKYDSECEDNVREKAAKALRKIGEKKIPQIVPLLKNKEDFWIRYLALKELVNTGEKAVPSLTPLLKDSDEYVRNSAVYALKEIAKENPKTVISYTRRFLQEEKNQAALELLNSCVWQAYIEEDKSVFSQEDIQLLAISEDYNILNTTATIYAWQGNTKKANIYSSKAFRETAKRVKLLLEGKTPKQVEEEIKTKNSF
>NZ_AP019860.1|WP_151970234.1|6206424_6206895_-|hypothetical-protein
MLLPQDHHFEPRPQILEPFSDIFGMNSLLSSEYIGISIWAKNTSPLLKDLDRYVKIVTGMALRKLREEALPSIRYFLQKEKDKQAIESALQILGEYLQAAYIKENTSSFTQVDVMLLSKSKEKGHLDTVAAIYVWQKNAEKAHMLPLKQKRIPQKE
>NZ_AP019860.1|WP_151970233.1|6205222_6206125_+|hypothetical-protein
MSKQNNTETFYKVITMFLLFFPLILFLPLLTYGVPNQTTTLILLICVSWNFVWHLLWIKYEKVTMAAKIIILLAPICFWFDICFLGWRTYSQDICRGRMRCEFADMLFFVRNGKNTHLINKWLGETAPHWTHSHIGGSPFSLVVDGNERVNTHSIVHQYYLPRILKLLPHDNARKQVLQCVCDSQNQLRFYQGLLMVCVMEWGFPEKKTAEEWWQKHQHFFIHESDGYEAAKTVVNWRLKIEEITRKKFGLRDRGTEVEVQLRAIEYLENGYRTKEKSFVREIAEDIIKPYHPVEPQWWK
>NZ_AP019860.1|WP_151970232.1|6204916_6205129_+|hypothetical-protein
MSDKTRLQEKTPPENREGKEVISIFENLCQELISYVLHCFDLACSSLVYIVYFVLVVLIMISVSLFITLL
>NZ_AP019860.1|WP_151970231.1|6204419_6204746_-|hypothetical-protein
MKRWNKISLTLLVTHVVIVCLLSGWSYCDVKNLELGIYFKLGYLLNLPLVVGHVLEMVIYFWSLFAFPLTALLLPIFYKKQVVNSGERLLCHVFLSIFQFYALLPLVT
>NZ_AP019860.1|WP_173013501.1|6203921_6204293_+|membrane-protein-insertion-efficiency-factor-YidD
MKILAIQAINFYQRFISPYKGFCCAHKVHHKQESCSQYIKRQILEKGLWNSLRLAGLRFRECKEASIVLNSSIENQKYEQPRKQEKANGYRVKNRLTTSNCNTTSLACETADCCFIASMFRFF
>NZ_AP019860.1|WP_173013500.1|6203456_6203855_+|response-regulator
MNSKYKILIVDDKWENRFFLRTIMENIPAIELLEVENGKEAIDAWHNWQPNLIWMDMCMPIMNGFEATKTIRKLDTSCKTKIIAISAFSSKEDRKKISQLGCDDFVKKPCRIVEIHNCLKRHVPEIILPKDD
>NZ_AP019860.1|WP_151966752.1|6201956_6203207_+|hypothetical-protein
METGIPLIDRVQEIYPWYKSEEYKKLEERYGTRVKETLNELILYPIFQFDSINDISQTLQKNKNKYYDLLKDKDVDWWQLIKEISFGLLVTFLKKYRSKKEKSSKSRWKIRLILDSTIIKRWGRKMAYTFNVYNPTDRCYMHAQKLLFFAVCVGKDKFIFPLAPTFITSKQHPNHVSPKVQIKQMLLELNNYVHANGLTLDGVRMVTDSEYSIIEVMKLAKQLGLEFYGALKSSWVVNIDSVDTHVLELKNGCIPKPPKHSHSIGLYYRLNASHNILGDIALLIKPYFCPFTRRLKYSVFLSSNPNVNSNVIHQEHSVRWKIENMFRDFKHVLAIASYHGTYHVAQNASFAISSLRFIFARLSLKVAALSPSLRWNIKNTKFTLTKLSRYIRDHYFLDSKSFKLKRLQYSPLSSVR
>NZ_AP019860.1|WP_151970228.1|6196732_6201625_-|caspase-family-protein
MKNIFIYVLFLSSCVFSQNDEKISAWITQLQNPDQCFFAIEKLKAVGPQAKKAIPFLKTVLQKALRDNDTRLFNAVFVAIAEITPDIMQTAQEKSTTHNKQRSIAKKSYENFGGLTVLGLSQDFRQKLRYNRSHAVIVGINRYKHHPSLHGASYDAAEIAAVLASRYGYHNITLITDTLPQKIYPLRYLEEIASNNVYTTYRHRLNKENIVVVHPRHFVTGELIEKCISRIKVENKYESLFFFYAGHGIPGSFVLGDSPKNSGYPLAKIANTLSEVKAHHTLMVLDSCFSGSLLQNPHRPQLQGYRDQQLLFGRGENIDRVFARRSFQVITAGTGSEAVEDQLSNSTRYAQLTGEGEHSPFTAVFLQAIKGLAGRADGIQLASDLGYYMMSNLVNDRRIQASQAPRYSSLAGDGDFMLFPKDLVLNPKLIAPLYLDEKSYADIRIATCEALKSFILEQPQQQRLALTKSAMPHVGKLLQESRVKTQVAAVTFIRDMLKRFPAQKVNEVQAFVLPITQLLANTNHQESSQIRLLLSCLGKMSFFATPQSMDVLKNLVEKHYIRDWQQIDKQELPNDVKDYVQRLENLKLADANTQQQQMDYWIEKGVIYEWLTSTGKVHIANHKDRLEKRHQQGLLLLKNAKKLYEEKDFFTAHFTMARATNFANVDKTPARKSKFLKNYSKEWFEAYRLLNSNLHCTLQWQNAAFSQHTGAVTCIDKNQQNTLLASGSSDKTIKLWDLQSRKLRAVLYGHKEKVNAVCFHPQEEVLFSAGDDALIVWELKTHSKKMELTGHTEHITSLALSPDGVYLASADTDGNIHLWDTKTYENKRSFPAKGHINISSLSFISKNTLAFTKLQKNTFFTWNIKTGKQKEFIGHKQQVNHVIGNDSFLLSASRDKTVKMWDFKTQKLRHTFSHPNIVRKLALSQENILATACGDKTIRLWDLSNKKLRHTMHGHKDATQALLFTPRHLISANNDYTIGLWDLNTGKPLRDYKNYYGTPVRSVLSEDGKTFAVGYSSGSIRLWDTKSGKSTLSLHGLSNWPLAIALSPDGKKLGAVSRNIIFVWDTKTGKPLRFSYGRFGRSVNIIRFGTKSEQFFFAYGNRIYSWNLHNKQQKTFTAHNGQITSFDCHNNMLLSSSADKTVKIWDIANHKLINKLEHSHPIGMAKFINNGKVLTCSTDKKVIIWDTETKKISQQIQEDLSYMYAFASTDQKFCVVLGQNEKNKKRLHLWNVTSKQKIHSWQCPRGNWLNVVCFSPDNRLVAYTGEDNKIYIHDLENKSLVAKLSGHSQTIRSIHFAKNSRSIFSIAADNTIKSWKIEVAKNHRSIDNCVIDIIFHKKRNLYAAISKNLRNIKLWKDPNNITILKGHKKRINQIAFSANGKYLASASADQTVRVWDVESQKLLMTFTHQDRVESVCFHPKNEILASAGRDKVIKLWSIKTQKWIKDLQGNTGWIQDLRFSSDGNTIFSVSTDKKLMMWRWKTNDVIKRSGHSSVIRSIDLSPDGKLLATGSWDKSIILWDAKSGNPIANLSGHEEMVYKVKFTPNGKYLLSASEDKTIKIWSLQHRRAIATFSGHKKSVTGLCILDEENFASVEHDYVAKFWRINFPTYEKYESFFDSDFRFRNFSNMLY
>NZ_AP019860.1|WP_173013499.1|6194913_6196548_-|DUF4157-domain-containing-protein
MSKSLVLFLFFSFNFIFSDFDLKKLKPPANPIKKLEEANKHVIKKGKETTNHVRRDLKNGAKTLSNFAQGKPWKTYIRFLNNQANGRKKRLPNWFIKKIQNYYRDINLAKVQYAEGINLGTGDLQDAVTIGYDIFFRGHITWTEEKDRRLMLHELAHAVQYKKAGGIDNFMKRYFYEASQTTFENSNNIHKIKITSTHRFRDSISGLIDIHGNMTLEKNAEGKAKYVMRDLQRQNNINQQTSKNQHNKSFIYIHNPTNERIYVILGYQPPGKRPIQQGFVIHPSKNLRVTRETGKYVYYYAFNRINSLIWQGNSPGRIKNVKTLFQRFAKEIKSPKTNQVVRFKKLFIPNTRGLQIVLHPNTATSSNKFQPTNRHYNQHHVQTQTPIQRQTQRQETEEERQLRIALQGTAKIVEAVGNQIDQSIQRYNTDHQYQENPSSNAPLHVKRDIRKRSTYYNSFYLEFKNLRFRDVVVTLRSPDVFGGKKMKVIVPAQGKKFLSMKGKFLSFRKVYFMAQEKGNGKKWMQFVRKPLTSKKKKSLTISFR
>NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein
MLNLKNWPLLCLLLHWSIFLPAQDMCKTVDLSSENFTEQTHQQEEQSGLSLVGAVKKLWPKNERVLHVRFVGIRNRILEQQIQKIVEDNWEQCCGIDFVFDNSSKAQITVNISSSQGNNSYVGTDSKGKNPSMNFLFYYYDKKSKKTKLRSDVLREIGGKKVIPYDSYTYGTILHEFGHAMGFKHEQQSPNFRVEWDEEKLFNYYKEIYPKKEDEVVRSMMSINMTKLKGSSFTRRVYGKVQQINSDSSNNQGYNTGPFQSEIVEVRFKPMHATTDFDPHSIMCYPINLHLVKDYSKYRLGILDGKHEEDLKGWRNTLEMRYDFRKEGLEIDKDAEIILYRNNDNIYIRTNIDDIRYILMPNSKSGNLDIYPWWGGRHTLSSVDRYFANKLYPYTRSSDNHRFVQRELYRAFEEILSRQPDINEIVECSNYMHDYGLLEMRYLIAKKATKKIKSFYLMYTGSEASDEFVEDSRQQLVERNMDDVVIKKLLKNVTIRSQEQFGEQQANIEKAVNIDVSTFQNAPGGEMMLKARRKITLKPGFHAKKGGKFLAEIHKE
>NZ_AP019860.1|WP_151970238.1|6223694_6225851_-|hypothetical-protein
MKTVYFILFFIATNFLASQEKQLYLDCGFETGKNLKVGVIHKSLNDIQTTQRFGSSKTELMAKKQIFFKPGFHCKNLRAHIDKSDIHRIAIFGPDSFYENEQPQFEAYASFSENEPCSYRVTDKCEWMITPNGYAKLENKVFQNQIKKVFKTLSTDSRDLEVKIVAAFNGVSVKKSVTVYRKGITHLTVKWDSKEIPEGYKSTKDLNTGAGGEYIYLCYKVETPENPDDRITGLFLVAGPENVSAPPGYTLRGHDLNAGAGGSYIYMAYKKGGYNPLQEIEVLTRHEESTKGYEKIPLDLNWSVGGEYLYLSVKGGEELIYQIVGEKSDYQKQSDWDAFTGWADEKGEHLGNFVKATFNIKRHLRVTNDYLADRSKVLNTYIDNRFRTLEDSLRTELKAGGKYLDERIRAVENFDLKNYDPQNEWEHGMKFLKRRKETLKKASMVEFNRLEGTLLRELLNALMDRDTEIPKKFHQNTDSQGKTLDGHIIYYVNGVATTEKKAQTSMRMLADTLQHPIRVIYNKSHDDPDGYNTGNKFYALDFTETLSDLDWYNLAPFEETLRVLSKLAQEFLSFDVTIPRDPRRLLDKIYVSNYCTRRVAGLMYEKAQKGEPMTIVSHSQGCVIVRNACFIMQILGYRPWVKKHLRWVAVGSPVNENFNHPRPPEQENRYYRLVDNDDIVVNSVGMSGLSGWSFDAHDFNEVYIPRLRGIMKDLDMIK
>NZ_AP019860.1|WP_151970239.1|6225875_6227564_-|hypothetical-protein
MKILFLFFLFPISLFADYYGPVKTVYKKIPTETYLGKKLFDGAQKNNTVTRKKVQLIPGFHTTQSRIRISRNIPTGISVSGISALYEKRSAKYKATAHFPDTTLDITNVCKWIVSHKSYGGIFQGNFEAKTVPYDIEIDIVAAFAVEGVVFEVKFPVKILKLGITSIQAGIDKEISGAIEKAEANGHKHIEVRGTNSFTSGTAPTTPHIFLGVKTEPISPDNRITGIAIVAGGKEIPISPGYKVVVDLNKGCGDGTAYVYLCIKTGGNNPIENLIAAKDAMGLPEPGYTRINLSTNFGCHQHIKESIQSPLREYHGQDIYIFVKGGNEILAIPYGNDEDYLHKNIEGYVNQKLEILKGEVEKAKETAQTIQRELQKIEKAVSNVVGYETNKWDKREEIYNHENEDGKGRWTVAWGREITETDLAEILVAIGIDIYGGGGNATLTKIEEIGIESFEKITTNTIETFSLYLEKTARQIADEMLNDIDNLVFDVMERFFKALVDGKDPDEAVRSFVNGKINSYGSIRIHVRAGVASYSGSNKLFGQTASKTFSWQPFVAIRVVRD
>NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein
MQKYIVTLLFLSIVGFTTAQNHTETINATNLHVKSAESPTSLLLEHESGKWKLTSSGPHFYLSNMKSGEDLFAVKSNGCIAIGTNTNLNGVSHRLFVDGSIKASGNIFSQNINSGLIKASTNIIAQNKIGIGTDSPEGVLHAKSTENYASLLLESNLGKWKASSSGTNFYLSNMKSGEDLFAVKSNGCIAIGTNTNLNGVSHRLFVDGSIKASKDIIAQNINAKKVNITDLTLGTGKIMSPTELSFNTPVGKAMTIDKDGWVAINAQPSDKYTLTIGGHTKINNNLNVSGAIGVGTTDPKANLHICSEKHFTSLRLDNHKGNWRLASSGGSFYISNYTTTPARDLFAINEGGNVGIKCSPHSTYSLAVKGKVLAEEVLVALHQDWPDFVFDDSYNLTSLEEVEQQIKKNKHLPDIPSGKEVKQNGIQLGAMQGKLLQKIEELTLYTIQQDKQIKSLKVEKHQMKERMEAEKLEMQKRLEKVEKLLHGLLKK
>NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase
MHRKNEKDFTRERKLPFSRLMVFMIRKSIKSIQNRLNEFVKDLLTNFTTVTSGAYTKARKKLNYTAFIELNKQAVVETLYEDEDYRKYKGFRLCAIDGSKVRLPNEKEIEEHFGTIRYKNKNISVEGSHAFATVSVLYDLLNEIAIDSEIGHCKKDEELFAYKHFQHANENDLILFDRGYCSYTLLAHLCKKGINFVVRCPVNSFYQANKMFKQKIESCITTIEPPDDKKKLVNDQSLPSKISVRFVRVMLDTGDVEVLVSSLVDEQLYPTDDFKELYWFRWGIETFFDRIKNRLDLENFTGKTTLSVQQDFYATIYISGLESILIEDAQDILDQKTSSNKYPQQVNKSVSFNTIKNYALDLLFENDSDLLFEKLTQLFLSSPTCIRKDRPRPRVKSPRKQVNYYKRKRKPTY
>NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein
MGEIGESEKVILALIPLLDENKNYDIKLSATEALEKIAKKATLPFISLLQNKKFFVRRYAAKVLGEIGEKAHPAIPDLVLLLKDKSSNVRWEAVKALGKIGEKSYSTVSYVIPLLRDQDSVVRREAVKTLGMMKESAYPMVQYIIPLLRDGDPNVRWEAVEALGVIGKKAIFSLISLLEDKDQHVRKAAAIAFGRIQESEFSTEECIIPILENLSKNQDYDVKIFATISLINMREKAISSIILLSKDSDVIWQVLEALREIGEKTYSVVPHLIPYLIHLMKADTDVTQDVIKAIGKKAIPSIIPLLKSEISDVRCSAAIALVMLGEKATSATPYLSSLLKDEDSNVRRYAAYALISLLKYENSDVIKEAKKVLGLKKNAYPMIHLLENEYFERNALEALAKMGEKAVPYLIPLLKDPDVERSVIEVLGNMGEKAIRQIIPLLQNEDKNIIKNAAEVLGEIGEKAEKVDNVVSHLVPLLKNENSDVVCSTLLALGEIGEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAENIIPKLIPLLEDQISNVRHSGVEALGKIGEKAVPDLILALKDQDEDVRKNAARALGKIGEKAEKAVPTLIAALKDYDWRGRGDAAKALGNIGKKTEKIIVALISLLEDQDYYLRGDAAEALGKIGKTTLAIQHLIPLLQNDSKYVRSFGKEALEKIKRKGKEAVPCFIPLLRDKDFWIRYSALKALVDMGEKAAPSLIPLLKDSDKDVQNSAVYALKEIAEKNSLKTVIPHIRQFLQIEANQKVLGLKVLNSCVWHAYLEEKKNVFTQEDIQILSKSEDYEILNTVAAIYAWQGNTKKANMYSSKTYKETAKRVKLLLEGKTPKQVEIELKENQ
>NZ_AP019860.1|WP_151970242.1|6233709_6237927_-|HEAT-repeat-domain-containing-protein
MMKRKYLPYVVILFMLFCLTFAQSEDDNLNKRLNKILQQLQLKDARSHLLALFELEKMGTNAISVQSDLQKLLAKANDENKKAIEYALDIIKRYLPPQTLQKKFQKTTTKRSLASRVSKNLGGLNILGVSSDFRQRLRYGKRHALVIGINKYNKYYPELDGPNYDAGEVASVLSNRYGFENVVYLCDTIPANVYPQNELKEKTQSKFTPYGKTYTTKYNNTTIVVNPLITKKVIKEFLYQTFSKVGSNDAIFLFYAGHGVPGNIVATPENKNENGYISLTKVAKDLSQKNAKHTLMVLDCCFGGSLLQDKYKPKLQGYNNATFQFGTGENIDRLFARRSFQVISAGTGNEVVADKLSTSAKYAQLTDTSGHSPFSAVFLQALKGLVGRDDGIVLTSDLGYYMMTNLTNDKRLNAKQTPRYGSLGGDGDFMFFPAYKVLNPKLLAPLYLSDKVYADFRSSGCEALGKFINDYPEQDQISLTKSALPHIAKLLEDEELLPRKTALKFIQEKAQKHVREIKEFDDIVSVLTKYFSYQNKERKVIDLESFFSLKNQKQDEADLYEVVDCLGALHFYADEKAIDILKGYSNRLKLKWEKSSKDKAKPKRIQNKVDKLQELQKMISKKFQSQAQIYHQIVKEYHWLINTGIEELKLYENRMHLFLSKTDDPERKRAFDLLKDELKDSDCSKHFEVFKKYFGIRDQYLREEVLKYLKEKGKDMETLLRLLKEENKNVKEDIAKDLEKIGEKAFLAIVKELKRDKSKNRISKKLLFAFLTWEKVSFFKLIDKLNTQDQDFFIPILAEENFNDIYQTMIDVNQKEDIRSKAASVIARLDKKEPFIAHFFLSIDQRDRFDKQSAIDILTSKETVTEYSTITILLELLKHENENVRSSVANTLGEMGEKAHSAVPYLIPLLQDPHKNVRSSAAHVLGKIGEKAEQAIDDIVSLLQDRNSEVRKSAAEALGGIGQKARLTVKYLTPLLEDDLINVRTTVIKALGNIGGKAVVPALILALKDQDENVRFSAKLTLGGIGEKAVVPTLTLALRDQDRDMRKTVTKVLGNIGGKAVVPALTLALRDQDRDVREYAAGALGKIGEKAEKAVPALILALKDQDVYVKQSVVEALGDIGEKAEKAVTALIFLLKDKNDLVRRYTVNALGKIGEKAVPALILALKDQDVYVKQSVVEALGDIGEKAEKAVTALIFLLKDKNDLVRRYTVNALGKIGEKAAPALIRTLKDQDYGVRGYAADALGEIGEKAEEAVPVLIPLLKDQDWRVRSSAAGALGKIGEKAEEAVQALILLLEDQSEDVRESAVSALGEIGEKAEEAVPVLIPLLKDQDWMVRESVVSALGDIGKKAKKAVQALILLLKDEGNLRYLAMVALRKIGEKAEEAVPALILALKDQDLYEHEKTLS
>NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase
MIKMDMYGYIRFAHGKLGKSINSIHRETKKARETIRKAIKGIEPKYRLTKPRRKWVMGPYMEIITKWLEEDKKVPVKQRHTAKKIYDRLVEEYSFKGAERTVRSAVREVKEKIGILNNESFIPSDPEKRHGSEVDWGEAYVDIKGSRVKVYMFCMRAKYSGKIFVKLYPTMAQECFFNGHIEAFAYYGGVFDELVYDNLKAAVQKVLRGRQRIEQQSFISFRSYYCFSPQFCSPAKGNEKGGVEQLVKYARRNFVTPIPECNSLEEINNKLLEQCLAHIMRQKNKEKITIGEKFQQEKSRLLKLPHSPYNNYKLIEKRVDKYQTITVDHNKYSAPYDYVNKNVVVELGLSDVRITYQSKLIARHQRVYHRGYWQLDPWHYMEMLRKKSRAFKSSRILTTIEEKWSPVVKELWNQQRLKYGDEKGTKEFIDSLLLFKNKDYGDMISVIELAIENNTFCKASIQNLYDALTEKEIVAGEASVDHIKAIKEFDLPQPDVNKFDQLMEGQNAN
>NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein
MPTKTNLQVLLRELKLKAFQENYEQYISGKVNLEKTLLKLCQLEREKRFSAKVKRRIKAATFPKVKTQSMLDYKKAPKLPKQKVQELFTTEFIKQKENVVLVGDSGGGKTHLAIALGIEACQKDISVKFYTASQLVNKLLSEYKEGRIEKFMMKLRKYGLLIIDELGYVPFSKKGAELLFQVFSDRYEAGSIVVTSNLNFSEWTQVFIDKKMTTALLDRLTHNATIIKYN
>NZ_AP019860.1|WP_151970245.1|6241163_6242870_-|protein-kinase
MNDLEFKSLWTKVIDKKILDSDKISHTYKPNDMTFSNDITVFPTHQTFSEQNTLVIKNIDQTFSGEKTVGAQTDETFSNEKTTALCLESPDINFQKNDQDIQQVDAQTDVISQAWQNKLKRKVSIKKIPSTSHNNKVLTEAQVTAYLEHPNILPIHNIEENAQGQTLLVMKLLEGYSWSQLLHPQTEEQKNKSKQYNLSAHIRILTKVCNAVRYAHSKGIVHCDLKPENVLIGNYGEVLVIGWGIAVSVDNDVKKVSILYKDSICEPMGTPCYMPPELAEGRGKDISTTTDIYLLGAILYEILHKSAPRKNKNLWNTLLEAQSGTLPKFDGKNPQNLINTCQRAMAKHTHLRYQTVDEFQMEIESFLSNQESVVISDEAKSNLDNCLERMKNLNSEIVKTKKKSFFTKRQEKQKEKLKAHLYDMFIESIFGFKNASEIWQENVEAIQGEITARLEYANFAFQNADTNLALSQLEKLDELDTTQKNKEEISELYEKIARDKRDVYSKINHHTHGVLSVTISIIGACILFVVFFHAFIFFSKWIPSPVFEVSIFIAIIITLIKVASIKKR

Crispr_ID: NZ_AP019860_28

• CRISPR_ID: NZ_AP019860_28
• CRISPR_location: 6214414-6214551
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_28

Consensus_repeat	Method
ACATCTCATTCCTCTACTAAAAGATTCTTATACACAAGAAGTAGC	CRISPRCasFinder

spacers of NZ_AP019860_28

>28.1|6214459|48|NZ_AP019860|CRISPRCasFinder
GACAGAAGCATTGGGAAAAATAGGAAAAAAAGCCGAAGAAGCGGTACA

CRISPR arrays and Neighbor proteins around NZ_AP019860_28

CRISPR arrays

The CRISPR arrays of NZ_AP019860_28

>merge|NZ_AP019860|28|6214414-6214551|CRISPRCasFinder
ACATCTCATTCCTCTACTAAAAGATTCTTATACACAAGAAGTAGCGACAGAAGCATTGGGAAAAATAGGAAAAAAAGCCGAAGAAGCGGTACAACATCTCATTCCTCTACTAAAAGATTCTTATACACAAGAAGTAGC

>NZ_AP019860|28|24|6214414-6214551|CRISPRCasFinder
ACATCTCATTCCTCTACTAAAAGATTCTTATACACAAGAAGTAGC	GACAGAAGCATTGGGAAAAATAGGAAAAAAAGCCGAAGAAGCGGTACA
ACATCTCATTCCTCTACTAAAAGATTCTTATACACAAGAAGTAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein	unknown	unknown	gnl|CDD|366760
NZ_AP019860.1|WP_151970238.1|6223694_6225851_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970236.1|6215564_6221918_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151970226.1|6194529_6194892_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013499.1|6194913_6196548_-|DUF4157-domain-containing-protein	unknown	unknown	gnl|CDD|379338
NZ_AP019860.1|WP_173013500.1|6203456_6203855_+|response-regulator	unknown	unknown	gnl|CDD|381099
NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein	unknown	unknown	gnl|CDD|293879
NZ_AP019860.1|WP_151970233.1|6205222_6206125_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NZ_AP019860.1|WP_151970234.1|6206424_6206895_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein	unknown	unknown	gnl|CDD|239819
NZ_AP019860.1|WP_151970239.1|6225875_6227564_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151970231.1|6204419_6204746_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase	unknown	unknown	gnl|CDD|226950
NZ_AP019860.1|WP_151970242.1|6233709_6237927_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151970232.1|6204916_6205129_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151966752.1|6201956_6203207_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013501.1|6203921_6204293_+|membrane-protein-insertion-efficiency-factor-YidD	unknown	unknown	gnl|CDD|376620
NZ_AP019860.1|WP_151970228.1|6196732_6201625_-|caspase-family-protein	unknown	unknown	gnl|CDD|238121

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein	gnl|CDD|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.37953e-65
NZ_AP019860.1|WP_151970236.1|6215564_6221918_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	1.67946e-38
NZ_AP019860.1|WP_173013499.1|6194913_6196548_-|DUF4157-domain-containing-protein	gnl|CDD|379338	pfam13699, DUF4157, Domain of unknown function (DUF4157). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteristic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.	1.63297e-05
NZ_AP019860.1|WP_173013500.1|6203456_6203855_+|response-regulator	gnl|CDD|381099	cd17546, REC_hyHK_CKI1_RcsC-like, phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC. This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	1.37381e-30
NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein	gnl|CDD|293879	cd16269, GBP_C, Guanylate-binding protein, C-terminal domain. Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.	0.00657934
NZ_AP019860.1|WP_151970242.1|6233709_6237927_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	1.20629e-39
NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein	gnl|CDD|239819	cd04327, ZnMc_MMP_like_3, Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.	2.70408e-23
NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.96929e-35
NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.09725e-07
NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase	gnl|CDD|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.22796e-18
NZ_AP019860.1|WP_173013501.1|6203921_6204293_+|membrane-protein-insertion-efficiency-factor-YidD	gnl|CDD|376620	pfam01809, Haemolytic, Haemolytic domain. This domain has haemolytic activity. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	2.20447e-08
NZ_AP019860.1|WP_151970228.1|6196732_6201625_-|caspase-family-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.1852e-68

Protein sequences

>NZ_AP019860.1|WP_151970234.1|6206424_6206895_-|hypothetical-protein
MLLPQDHHFEPRPQILEPFSDIFGMNSLLSSEYIGISIWAKNTSPLLKDLDRYVKIVTGMALRKLREEALPSIRYFLQKEKDKQAIESALQILGEYLQAAYIKENTSSFTQVDVMLLSKSKEKGHLDTVAAIYVWQKNAEKAHMLPLKQKRIPQKE
>NZ_AP019860.1|WP_151970233.1|6205222_6206125_+|hypothetical-protein
MSKQNNTETFYKVITMFLLFFPLILFLPLLTYGVPNQTTTLILLICVSWNFVWHLLWIKYEKVTMAAKIIILLAPICFWFDICFLGWRTYSQDICRGRMRCEFADMLFFVRNGKNTHLINKWLGETAPHWTHSHIGGSPFSLVVDGNERVNTHSIVHQYYLPRILKLLPHDNARKQVLQCVCDSQNQLRFYQGLLMVCVMEWGFPEKKTAEEWWQKHQHFFIHESDGYEAAKTVVNWRLKIEEITRKKFGLRDRGTEVEVQLRAIEYLENGYRTKEKSFVREIAEDIIKPYHPVEPQWWK
>NZ_AP019860.1|WP_151970232.1|6204916_6205129_+|hypothetical-protein
MSDKTRLQEKTPPENREGKEVISIFENLCQELISYVLHCFDLACSSLVYIVYFVLVVLIMISVSLFITLL
>NZ_AP019860.1|WP_151970231.1|6204419_6204746_-|hypothetical-protein
MKRWNKISLTLLVTHVVIVCLLSGWSYCDVKNLELGIYFKLGYLLNLPLVVGHVLEMVIYFWSLFAFPLTALLLPIFYKKQVVNSGERLLCHVFLSIFQFYALLPLVT
>NZ_AP019860.1|WP_173013501.1|6203921_6204293_+|membrane-protein-insertion-efficiency-factor-YidD
MKILAIQAINFYQRFISPYKGFCCAHKVHHKQESCSQYIKRQILEKGLWNSLRLAGLRFRECKEASIVLNSSIENQKYEQPRKQEKANGYRVKNRLTTSNCNTTSLACETADCCFIASMFRFF
>NZ_AP019860.1|WP_173013500.1|6203456_6203855_+|response-regulator
MNSKYKILIVDDKWENRFFLRTIMENIPAIELLEVENGKEAIDAWHNWQPNLIWMDMCMPIMNGFEATKTIRKLDTSCKTKIIAISAFSSKEDRKKISQLGCDDFVKKPCRIVEIHNCLKRHVPEIILPKDD
>NZ_AP019860.1|WP_151966752.1|6201956_6203207_+|hypothetical-protein
METGIPLIDRVQEIYPWYKSEEYKKLEERYGTRVKETLNELILYPIFQFDSINDISQTLQKNKNKYYDLLKDKDVDWWQLIKEISFGLLVTFLKKYRSKKEKSSKSRWKIRLILDSTIIKRWGRKMAYTFNVYNPTDRCYMHAQKLLFFAVCVGKDKFIFPLAPTFITSKQHPNHVSPKVQIKQMLLELNNYVHANGLTLDGVRMVTDSEYSIIEVMKLAKQLGLEFYGALKSSWVVNIDSVDTHVLELKNGCIPKPPKHSHSIGLYYRLNASHNILGDIALLIKPYFCPFTRRLKYSVFLSSNPNVNSNVIHQEHSVRWKIENMFRDFKHVLAIASYHGTYHVAQNASFAISSLRFIFARLSLKVAALSPSLRWNIKNTKFTLTKLSRYIRDHYFLDSKSFKLKRLQYSPLSSVR
>NZ_AP019860.1|WP_151970228.1|6196732_6201625_-|caspase-family-protein
MKNIFIYVLFLSSCVFSQNDEKISAWITQLQNPDQCFFAIEKLKAVGPQAKKAIPFLKTVLQKALRDNDTRLFNAVFVAIAEITPDIMQTAQEKSTTHNKQRSIAKKSYENFGGLTVLGLSQDFRQKLRYNRSHAVIVGINRYKHHPSLHGASYDAAEIAAVLASRYGYHNITLITDTLPQKIYPLRYLEEIASNNVYTTYRHRLNKENIVVVHPRHFVTGELIEKCISRIKVENKYESLFFFYAGHGIPGSFVLGDSPKNSGYPLAKIANTLSEVKAHHTLMVLDSCFSGSLLQNPHRPQLQGYRDQQLLFGRGENIDRVFARRSFQVITAGTGSEAVEDQLSNSTRYAQLTGEGEHSPFTAVFLQAIKGLAGRADGIQLASDLGYYMMSNLVNDRRIQASQAPRYSSLAGDGDFMLFPKDLVLNPKLIAPLYLDEKSYADIRIATCEALKSFILEQPQQQRLALTKSAMPHVGKLLQESRVKTQVAAVTFIRDMLKRFPAQKVNEVQAFVLPITQLLANTNHQESSQIRLLLSCLGKMSFFATPQSMDVLKNLVEKHYIRDWQQIDKQELPNDVKDYVQRLENLKLADANTQQQQMDYWIEKGVIYEWLTSTGKVHIANHKDRLEKRHQQGLLLLKNAKKLYEEKDFFTAHFTMARATNFANVDKTPARKSKFLKNYSKEWFEAYRLLNSNLHCTLQWQNAAFSQHTGAVTCIDKNQQNTLLASGSSDKTIKLWDLQSRKLRAVLYGHKEKVNAVCFHPQEEVLFSAGDDALIVWELKTHSKKMELTGHTEHITSLALSPDGVYLASADTDGNIHLWDTKTYENKRSFPAKGHINISSLSFISKNTLAFTKLQKNTFFTWNIKTGKQKEFIGHKQQVNHVIGNDSFLLSASRDKTVKMWDFKTQKLRHTFSHPNIVRKLALSQENILATACGDKTIRLWDLSNKKLRHTMHGHKDATQALLFTPRHLISANNDYTIGLWDLNTGKPLRDYKNYYGTPVRSVLSEDGKTFAVGYSSGSIRLWDTKSGKSTLSLHGLSNWPLAIALSPDGKKLGAVSRNIIFVWDTKTGKPLRFSYGRFGRSVNIIRFGTKSEQFFFAYGNRIYSWNLHNKQQKTFTAHNGQITSFDCHNNMLLSSSADKTVKIWDIANHKLINKLEHSHPIGMAKFINNGKVLTCSTDKKVIIWDTETKKISQQIQEDLSYMYAFASTDQKFCVVLGQNEKNKKRLHLWNVTSKQKIHSWQCPRGNWLNVVCFSPDNRLVAYTGEDNKIYIHDLENKSLVAKLSGHSQTIRSIHFAKNSRSIFSIAADNTIKSWKIEVAKNHRSIDNCVIDIIFHKKRNLYAAISKNLRNIKLWKDPNNITILKGHKKRINQIAFSANGKYLASASADQTVRVWDVESQKLLMTFTHQDRVESVCFHPKNEILASAGRDKVIKLWSIKTQKWIKDLQGNTGWIQDLRFSSDGNTIFSVSTDKKLMMWRWKTNDVIKRSGHSSVIRSIDLSPDGKLLATGSWDKSIILWDAKSGNPIANLSGHEEMVYKVKFTPNGKYLLSASEDKTIKIWSLQHRRAIATFSGHKKSVTGLCILDEENFASVEHDYVAKFWRINFPTYEKYESFFDSDFRFRNFSNMLY
>NZ_AP019860.1|WP_173013499.1|6194913_6196548_-|DUF4157-domain-containing-protein
MSKSLVLFLFFSFNFIFSDFDLKKLKPPANPIKKLEEANKHVIKKGKETTNHVRRDLKNGAKTLSNFAQGKPWKTYIRFLNNQANGRKKRLPNWFIKKIQNYYRDINLAKVQYAEGINLGTGDLQDAVTIGYDIFFRGHITWTEEKDRRLMLHELAHAVQYKKAGGIDNFMKRYFYEASQTTFENSNNIHKIKITSTHRFRDSISGLIDIHGNMTLEKNAEGKAKYVMRDLQRQNNINQQTSKNQHNKSFIYIHNPTNERIYVILGYQPPGKRPIQQGFVIHPSKNLRVTRETGKYVYYYAFNRINSLIWQGNSPGRIKNVKTLFQRFAKEIKSPKTNQVVRFKKLFIPNTRGLQIVLHPNTATSSNKFQPTNRHYNQHHVQTQTPIQRQTQRQETEEERQLRIALQGTAKIVEAVGNQIDQSIQRYNTDHQYQENPSSNAPLHVKRDIRKRSTYYNSFYLEFKNLRFRDVVVTLRSPDVFGGKKMKVIVPAQGKKFLSMKGKFLSFRKVYFMAQEKGNGKKWMQFVRKPLTSKKKKSLTISFR
>NZ_AP019860.1|WP_151970226.1|6194529_6194892_-|hypothetical-protein
MKTTNFLLIVLLIFASGCSSKLAEYSIISSRTLGDSNTLVFTSESQAQRVSGSSSRVWFLFIPFGEAPRIQYAIDNALNNGQGDFIENAELSSSWWSILLFSYGSYSIDGTGRRVVRYQN
>NZ_AP019860.1|WP_151970236.1|6215564_6221918_-|HEAT-repeat-domain-containing-protein
MKKTIVLILILISFCTAENSDIKYWVNQLEQGSRNEKIKAIKELREKQVKSILPQLEEARRKALDANDDKLTLLISKVIRSIELSSKKTLQKKTQVSIRSRATNPPKKLGGLTILGSSPDFSSRQYGKCHAIVIGINNYEHFTSLAGPCLDASEVARVLENRYNFDNVHLLADTKPSTTINFKTQQVTKDLIKNKIEALRQKVKSDDALFFFYAGHGVPGYLVASDSSKDGLGKPNVKSMMSLTKIAKNLKSLGARHTLMVLDCCFSGSLLEGEYRPDFSDLANDEFVTPGGDNLTRVFKRQSFQIITAGTGDEVVADKLDEKSAIYAQQFKDSRGHSPFTAVFLQAIQGLTGRDDGVVLASQLGFYMMDTLVNDKRIKASQAPRYGTLGGNGDFMFFPTEKVLNPKMVAPLYLNGIEFASFRRSGCEALENFIDGQAHKKDQTALVKSALPHIAKLLQDEQTFPRMAALKFIKNVAQQHAHNIKEFSNVIPPLLKLAKSRNKFSSEDDYFKVIDCLGFLCIHANQEFVNVFKNYCNDQDKEWKEYKKDKKLPLVVRKERQKQNDLLQTLSTTTKKLQEQAKIYWQTIKIYQWLHTEGKIKIEFYKNGKKTFLLSTEDEEKRLKAFHLVKDEITDKEFIKYFETNDTNKVIREEVLLFLAKAKRDLPILFKLLQESNEDTKKQIAKDLEKIGERAFFAIVKKLDNSKNQTSRKLLFCFVSWQKKSLFKLIDQLSQEDQDFFIPVLAKKIFDSLYEIIINRNESEKIRSQAASIIKKSEMIESFLTKFFISINERDSFEKQIAIDIIISQEKYSTAKILLEVLKDQDPDVRRNAVEGLRNIKSIREAVPALIVALKDQDVDVRKSAAQALGNVGEKVKEAIPALIVALKDKDSETRSSAAQALGNIGEKAEKAVSALIVALKDQNVSVRGHVTQALGKIGKKAEEAVPTLIVALKDQNEGVRMDAAQALEKIGEAKEVVPALLILTLKEQVWMRIRAGKALESIGKKAIPALILVLKDKDSKMRYCAAKALGKIGEKALSAVPDLIFTLKDQSGDVRCCAAEALGKIGEKAYSAVPHLIPLLQDEEEYVKETVAEALGKIGEKAKEAIPALILALKDKDSKMRYCAVEALGKIGEKACSVVPDLILALKNEDPGLRAHAAKALGGIGEKAHSAVPYLIPLLQNNHAGVRSSTARALGKIGEKAYSAVPHLIPLLQDVYVRTEVVEALGEIGEKAEKAVPALILALKDPDEVVRSSAAEALGKIGEKAKEAIPTLILALKDESKWVEKSATEALGNIGEKAEKAVPALILALKDPDEVVRSSAAEALGKIGEKAKEAIPTLILALKDESKWVEKSATEALGNIGEKAEKAVPALILALKDPDEVVRWCVAQALGNIGEKAHLAVPHLIPLLQDEEEYVKEKVAEALGKIGEKAHSAVPDLILTLKDQSGDVRNSAAEALWKIGEKTEKLEKVAPALIFALKGRGRSVGVSVGRTLGKINNIKNIEFVVFLLKDESWEVRSYAVEALAKMGEKAVPPLISALKDKSSFVRSDAVNALSKIAKKAGKVEKSVSALILALKDPDEVVRWRAVQALGKIGKKAEKAIPTIILALKDQEGYVRKSAVKALSNIAKKAEKTQSVVPDLILTLKDENWDVRDSAALALEKIGKKAEKAVPTFILALKNQDKYVRSYAARALGKIGEKAYSAVPDLILAFKDQDKHVRYCAAEALANIGEKAVPPLIVALKDQNRDVREFAAKALGKIGEKAYSAVPALILAFKDQDKWVRSSAAEALAKIGEKASKAIPTLILALKDPDEDVRKYTTWALIEIAKKARKAVPLTLVLKDKNFIVRSYAVEALAKIGEKAVPPLISALKDKNFIVRSSAAEALGKIGEKAHSAVPDLILAFKDQDRHVRYCAAEALAKIGEKAEKAIPTLILALKDQDSKVRGATAWVLGEIGEKAEKAVPGLIFALKNQDLSTRRYAIWALVKIGKRVLLPIKKFIQTEKDEVAVASGLQVLNFYMRKAYLEEDKFAQEDLELLSLSKDKDHLDTVAAIYAWQGNVKKANQYTTGTSKRVKLLLAGKSPKQVEYEMQHEAWGDDSEYAMENEDWDDGDENWDDEEW
>NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein
MLNLKNWPLLCLLLHWSIFLPAQDMCKTVDLSSENFTEQTHQQEEQSGLSLVGAVKKLWPKNERVLHVRFVGIRNRILEQQIQKIVEDNWEQCCGIDFVFDNSSKAQITVNISSSQGNNSYVGTDSKGKNPSMNFLFYYYDKKSKKTKLRSDVLREIGGKKVIPYDSYTYGTILHEFGHAMGFKHEQQSPNFRVEWDEEKLFNYYKEIYPKKEDEVVRSMMSINMTKLKGSSFTRRVYGKVQQINSDSSNNQGYNTGPFQSEIVEVRFKPMHATTDFDPHSIMCYPINLHLVKDYSKYRLGILDGKHEEDLKGWRNTLEMRYDFRKEGLEIDKDAEIILYRNNDNIYIRTNIDDIRYILMPNSKSGNLDIYPWWGGRHTLSSVDRYFANKLYPYTRSSDNHRFVQRELYRAFEEILSRQPDINEIVECSNYMHDYGLLEMRYLIAKKATKKIKSFYLMYTGSEASDEFVEDSRQQLVERNMDDVVIKKLLKNVTIRSQEQFGEQQANIEKAVNIDVSTFQNAPGGEMMLKARRKITLKPGFHAKKGGKFLAEIHKE
>NZ_AP019860.1|WP_151970238.1|6223694_6225851_-|hypothetical-protein
MKTVYFILFFIATNFLASQEKQLYLDCGFETGKNLKVGVIHKSLNDIQTTQRFGSSKTELMAKKQIFFKPGFHCKNLRAHIDKSDIHRIAIFGPDSFYENEQPQFEAYASFSENEPCSYRVTDKCEWMITPNGYAKLENKVFQNQIKKVFKTLSTDSRDLEVKIVAAFNGVSVKKSVTVYRKGITHLTVKWDSKEIPEGYKSTKDLNTGAGGEYIYLCYKVETPENPDDRITGLFLVAGPENVSAPPGYTLRGHDLNAGAGGSYIYMAYKKGGYNPLQEIEVLTRHEESTKGYEKIPLDLNWSVGGEYLYLSVKGGEELIYQIVGEKSDYQKQSDWDAFTGWADEKGEHLGNFVKATFNIKRHLRVTNDYLADRSKVLNTYIDNRFRTLEDSLRTELKAGGKYLDERIRAVENFDLKNYDPQNEWEHGMKFLKRRKETLKKASMVEFNRLEGTLLRELLNALMDRDTEIPKKFHQNTDSQGKTLDGHIIYYVNGVATTEKKAQTSMRMLADTLQHPIRVIYNKSHDDPDGYNTGNKFYALDFTETLSDLDWYNLAPFEETLRVLSKLAQEFLSFDVTIPRDPRRLLDKIYVSNYCTRRVAGLMYEKAQKGEPMTIVSHSQGCVIVRNACFIMQILGYRPWVKKHLRWVAVGSPVNENFNHPRPPEQENRYYRLVDNDDIVVNSVGMSGLSGWSFDAHDFNEVYIPRLRGIMKDLDMIK
>NZ_AP019860.1|WP_151970239.1|6225875_6227564_-|hypothetical-protein
MKILFLFFLFPISLFADYYGPVKTVYKKIPTETYLGKKLFDGAQKNNTVTRKKVQLIPGFHTTQSRIRISRNIPTGISVSGISALYEKRSAKYKATAHFPDTTLDITNVCKWIVSHKSYGGIFQGNFEAKTVPYDIEIDIVAAFAVEGVVFEVKFPVKILKLGITSIQAGIDKEISGAIEKAEANGHKHIEVRGTNSFTSGTAPTTPHIFLGVKTEPISPDNRITGIAIVAGGKEIPISPGYKVVVDLNKGCGDGTAYVYLCIKTGGNNPIENLIAAKDAMGLPEPGYTRINLSTNFGCHQHIKESIQSPLREYHGQDIYIFVKGGNEILAIPYGNDEDYLHKNIEGYVNQKLEILKGEVEKAKETAQTIQRELQKIEKAVSNVVGYETNKWDKREEIYNHENEDGKGRWTVAWGREITETDLAEILVAIGIDIYGGGGNATLTKIEEIGIESFEKITTNTIETFSLYLEKTARQIADEMLNDIDNLVFDVMERFFKALVDGKDPDEAVRSFVNGKINSYGSIRIHVRAGVASYSGSNKLFGQTASKTFSWQPFVAIRVVRD
>NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein
MQKYIVTLLFLSIVGFTTAQNHTETINATNLHVKSAESPTSLLLEHESGKWKLTSSGPHFYLSNMKSGEDLFAVKSNGCIAIGTNTNLNGVSHRLFVDGSIKASGNIFSQNINSGLIKASTNIIAQNKIGIGTDSPEGVLHAKSTENYASLLLESNLGKWKASSSGTNFYLSNMKSGEDLFAVKSNGCIAIGTNTNLNGVSHRLFVDGSIKASKDIIAQNINAKKVNITDLTLGTGKIMSPTELSFNTPVGKAMTIDKDGWVAINAQPSDKYTLTIGGHTKINNNLNVSGAIGVGTTDPKANLHICSEKHFTSLRLDNHKGNWRLASSGGSFYISNYTTTPARDLFAINEGGNVGIKCSPHSTYSLAVKGKVLAEEVLVALHQDWPDFVFDDSYNLTSLEEVEQQIKKNKHLPDIPSGKEVKQNGIQLGAMQGKLLQKIEELTLYTIQQDKQIKSLKVEKHQMKERMEAEKLEMQKRLEKVEKLLHGLLKK
>NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase
MHRKNEKDFTRERKLPFSRLMVFMIRKSIKSIQNRLNEFVKDLLTNFTTVTSGAYTKARKKLNYTAFIELNKQAVVETLYEDEDYRKYKGFRLCAIDGSKVRLPNEKEIEEHFGTIRYKNKNISVEGSHAFATVSVLYDLLNEIAIDSEIGHCKKDEELFAYKHFQHANENDLILFDRGYCSYTLLAHLCKKGINFVVRCPVNSFYQANKMFKQKIESCITTIEPPDDKKKLVNDQSLPSKISVRFVRVMLDTGDVEVLVSSLVDEQLYPTDDFKELYWFRWGIETFFDRIKNRLDLENFTGKTTLSVQQDFYATIYISGLESILIEDAQDILDQKTSSNKYPQQVNKSVSFNTIKNYALDLLFENDSDLLFEKLTQLFLSSPTCIRKDRPRPRVKSPRKQVNYYKRKRKPTY
>NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein
MGEIGESEKVILALIPLLDENKNYDIKLSATEALEKIAKKATLPFISLLQNKKFFVRRYAAKVLGEIGEKAHPAIPDLVLLLKDKSSNVRWEAVKALGKIGEKSYSTVSYVIPLLRDQDSVVRREAVKTLGMMKESAYPMVQYIIPLLRDGDPNVRWEAVEALGVIGKKAIFSLISLLEDKDQHVRKAAAIAFGRIQESEFSTEECIIPILENLSKNQDYDVKIFATISLINMREKAISSIILLSKDSDVIWQVLEALREIGEKTYSVVPHLIPYLIHLMKADTDVTQDVIKAIGKKAIPSIIPLLKSEISDVRCSAAIALVMLGEKATSATPYLSSLLKDEDSNVRRYAAYALISLLKYENSDVIKEAKKVLGLKKNAYPMIHLLENEYFERNALEALAKMGEKAVPYLIPLLKDPDVERSVIEVLGNMGEKAIRQIIPLLQNEDKNIIKNAAEVLGEIGEKAEKVDNVVSHLVPLLKNENSDVVCSTLLALGEIGEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAENIIPKLIPLLEDQISNVRHSGVEALGKIGEKAVPDLILALKDQDEDVRKNAARALGKIGEKAEKAVPTLIAALKDYDWRGRGDAAKALGNIGKKTEKIIVALISLLEDQDYYLRGDAAEALGKIGKTTLAIQHLIPLLQNDSKYVRSFGKEALEKIKRKGKEAVPCFIPLLRDKDFWIRYSALKALVDMGEKAAPSLIPLLKDSDKDVQNSAVYALKEIAEKNSLKTVIPHIRQFLQIEANQKVLGLKVLNSCVWHAYLEEKKNVFTQEDIQILSKSEDYEILNTVAAIYAWQGNTKKANMYSSKTYKETAKRVKLLLEGKTPKQVEIELKENQ
>NZ_AP019860.1|WP_151970242.1|6233709_6237927_-|HEAT-repeat-domain-containing-protein
MMKRKYLPYVVILFMLFCLTFAQSEDDNLNKRLNKILQQLQLKDARSHLLALFELEKMGTNAISVQSDLQKLLAKANDENKKAIEYALDIIKRYLPPQTLQKKFQKTTTKRSLASRVSKNLGGLNILGVSSDFRQRLRYGKRHALVIGINKYNKYYPELDGPNYDAGEVASVLSNRYGFENVVYLCDTIPANVYPQNELKEKTQSKFTPYGKTYTTKYNNTTIVVNPLITKKVIKEFLYQTFSKVGSNDAIFLFYAGHGVPGNIVATPENKNENGYISLTKVAKDLSQKNAKHTLMVLDCCFGGSLLQDKYKPKLQGYNNATFQFGTGENIDRLFARRSFQVISAGTGNEVVADKLSTSAKYAQLTDTSGHSPFSAVFLQALKGLVGRDDGIVLTSDLGYYMMTNLTNDKRLNAKQTPRYGSLGGDGDFMFFPAYKVLNPKLLAPLYLSDKVYADFRSSGCEALGKFINDYPEQDQISLTKSALPHIAKLLEDEELLPRKTALKFIQEKAQKHVREIKEFDDIVSVLTKYFSYQNKERKVIDLESFFSLKNQKQDEADLYEVVDCLGALHFYADEKAIDILKGYSNRLKLKWEKSSKDKAKPKRIQNKVDKLQELQKMISKKFQSQAQIYHQIVKEYHWLINTGIEELKLYENRMHLFLSKTDDPERKRAFDLLKDELKDSDCSKHFEVFKKYFGIRDQYLREEVLKYLKEKGKDMETLLRLLKEENKNVKEDIAKDLEKIGEKAFLAIVKELKRDKSKNRISKKLLFAFLTWEKVSFFKLIDKLNTQDQDFFIPILAEENFNDIYQTMIDVNQKEDIRSKAASVIARLDKKEPFIAHFFLSIDQRDRFDKQSAIDILTSKETVTEYSTITILLELLKHENENVRSSVANTLGEMGEKAHSAVPYLIPLLQDPHKNVRSSAAHVLGKIGEKAEQAIDDIVSLLQDRNSEVRKSAAEALGGIGQKARLTVKYLTPLLEDDLINVRTTVIKALGNIGGKAVVPALILALKDQDENVRFSAKLTLGGIGEKAVVPTLTLALRDQDRDMRKTVTKVLGNIGGKAVVPALTLALRDQDRDVREYAAGALGKIGEKAEKAVPALILALKDQDVYVKQSVVEALGDIGEKAEKAVTALIFLLKDKNDLVRRYTVNALGKIGEKAVPALILALKDQDVYVKQSVVEALGDIGEKAEKAVTALIFLLKDKNDLVRRYTVNALGKIGEKAAPALIRTLKDQDYGVRGYAADALGEIGEKAEEAVPVLIPLLKDQDWRVRSSAAGALGKIGEKAEEAVQALILLLEDQSEDVRESAVSALGEIGEKAEEAVPVLIPLLKDQDWMVRESVVSALGDIGKKAKKAVQALILLLKDEGNLRYLAMVALRKIGEKAEEAVPALILALKDQDLYEHEKTLS
>NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase
MIKMDMYGYIRFAHGKLGKSINSIHRETKKARETIRKAIKGIEPKYRLTKPRRKWVMGPYMEIITKWLEEDKKVPVKQRHTAKKIYDRLVEEYSFKGAERTVRSAVREVKEKIGILNNESFIPSDPEKRHGSEVDWGEAYVDIKGSRVKVYMFCMRAKYSGKIFVKLYPTMAQECFFNGHIEAFAYYGGVFDELVYDNLKAAVQKVLRGRQRIEQQSFISFRSYYCFSPQFCSPAKGNEKGGVEQLVKYARRNFVTPIPECNSLEEINNKLLEQCLAHIMRQKNKEKITIGEKFQQEKSRLLKLPHSPYNNYKLIEKRVDKYQTITVDHNKYSAPYDYVNKNVVVELGLSDVRITYQSKLIARHQRVYHRGYWQLDPWHYMEMLRKKSRAFKSSRILTTIEEKWSPVVKELWNQQRLKYGDEKGTKEFIDSLLLFKNKDYGDMISVIELAIENNTFCKASIQNLYDALTEKEIVAGEASVDHIKAIKEFDLPQPDVNKFDQLMEGQNAN
>NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein
MPTKTNLQVLLRELKLKAFQENYEQYISGKVNLEKTLLKLCQLEREKRFSAKVKRRIKAATFPKVKTQSMLDYKKAPKLPKQKVQELFTTEFIKQKENVVLVGDSGGGKTHLAIALGIEACQKDISVKFYTASQLVNKLLSEYKEGRIEKFMMKLRKYGLLIIDELGYVPFSKKGAELLFQVFSDRYEAGSIVVTSNLNFSEWTQVFIDKKMTTALLDRLTHNATIIKYN

Crispr_ID: NZ_AP019860_30

• CRISPR_ID: NZ_AP019860_30
• CRISPR_location: 6234349-6234587
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP019860_30

Consensus_repeat	Method
AGCTGTTACAGCTTTTTCAGCTTTTTCTCCTATATCACCCAGCGCCTCTA	PILER-CR

spacers of NZ_AP019860_30

>30.1|6234399|56|NZ_AP019860|PILER-CR
CTACAGATTGTTTCACGTATACATCCTGATCTTTTAGAGCAAGAATAAGAGCTGGC
>30.2|6234505|66|NZ_AP019860|PILER-CR
TTTTCCCAATGCATTTACTGTATACCTCCTCACTAAGTCGTTTTTGTCTTTCAATAGAAAAATAAG

CRISPR arrays and Neighbor proteins around NZ_AP019860_30

CRISPR arrays

The CRISPR arrays of NZ_AP019860_30

>merge|NZ_AP019860|30|6234349-6234587|PILER-CR
AGCTGTTACAGCTTTTTCAGCTTTTTCTCCTATATCCCCCAGCGCCTCTACTACAGATTGTTTCACGTATACATCCTGATCTTTTAGAGCAAGAATAAGAGCTGGCACAGCTTTTTCTCCTATTTTTCCCAATGCATTTACTGTATACCTCCTCACTAAGTCGTTTTTGTCTTTCAATAGAAAAATAAGAGCTGTTACAGCTTTTTCAGCTTTTTCTCCTATATCACCCAGCGCCTCTA

>NZ_AP019860|30|3|6234349-6234587|PILER-CR
AGCTGTTACAGCTTTTTCAGCTTTTTCTCCTATATCCCCCAGCGCCTCTA	CTACAGATTGTTTCACGTATACATCCTGATCTTTTAGAGCAAGAATAAGAGCTGGC
ACAGCTTTTTCTCCTATTTTTCCCAATGCATTTACTGTATACCTCCTCAC	TAAGTCGTTTTTGTCTTTCAATAGAAAAATAAGAGCTGTTACAGCTTTTTCAGCTTTTTCTCCTAT
ATCACCCAGCGCCTCTA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970249.1|6247235_6249626_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970238.1|6223694_6225851_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970233.1|6205222_6206125_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein	unknown	unknown	gnl|CDD|366760
NZ_AP019860.1|WP_151970235.1|6208072_6215209_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_173013503.1|6253011_6255126_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein	unknown	unknown	gnl|CDD|293879
NZ_AP019860.1|WP_151970236.1|6215564_6221918_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151970246.1|6242899_6244630_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970247.1|6244677_6244983_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970248.1|6245291_6247097_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein	unknown	unknown	gnl|CDD|239819
NZ_AP019860.1|WP_151970239.1|6225875_6227564_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase	unknown	unknown	gnl|CDD|376573
NZ_AP019860.1|WP_151970245.1|6241163_6242870_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase	unknown	unknown	gnl|CDD|226950
NZ_AP019860.1|WP_151970251.1|6251176_6252850_+|hypothetical-protein	unknown	unknown	gnl|CDD|260033
NZ_AP019860.1|WP_151970234.1|6206424_6206895_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970250.1|6249687_6251160_+|C39-family-peptidase	unknown	unknown	gnl|CDD|239109

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_173013503.1|6253011_6255126_-|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.28016e-53
NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein	gnl|CDD|366760	pfam01695, IstB_IS21, IstB-like ATP binding protein. This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.	2.37953e-65
NZ_AP019860.1|WP_151970235.1|6208072_6215209_+|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	9.60089e-34
NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein	gnl|CDD|293879	cd16269, GBP_C, Guanylate-binding protein, C-terminal domain. Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.	0.00657934
NZ_AP019860.1|WP_151970236.1|6215564_6221918_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	1.67946e-38
NZ_AP019860.1|WP_151970246.1|6242899_6244630_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.29546e-64
NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein	gnl|CDD|239819	cd04327, ZnMc_MMP_like_3, Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.	2.70408e-23
NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.96929e-35
NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	2.09725e-07
NZ_AP019860.1|WP_151970245.1|6241163_6242870_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.30936e-52
NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase	gnl|CDD|226950	COG4584, COG4584, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	4.22796e-18
NZ_AP019860.1|WP_151970251.1|6251176_6252850_+|hypothetical-protein	gnl|CDD|260033	cd08321, Pyrin_ASC-like, Pyrin Death Domain found in ASC. Pyrin Death Domain found in ASC (Apoptosis-associated speck-like protein containing a CARD) and similar proteins. ASC is an adaptor molecule that functions in the assembly of the 'inflammasome', a multiprotein platform, which is responsible for caspase-1 activation and regulation of IL-1beta maturation. ASC contains two domains from the Death Domain (DD) superfamily, an N-terminal pyrin-like domain and a C-terminal Caspase activation and recruitment domain (CARD). Through these 2 domains, ASC serves as an adaptor for inflammasome integrity and oligomerizes to form supramolecular assemblies. Included in this family is human PYNOD (also known as NLRP10 or NOD8) which via its Pyrin domain suppresses oligomerization of ASC, and ASC-mediated NF-kappaB activation. Other members of this subfamily are associated with ATPase domains and their function remains unknown. In general, Pyrin is a subfamily of the DD superfamily and functions in several signaling pathways. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD and Death Effector Domain (DED). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.	0.00210898
NZ_AP019860.1|WP_151970250.1|6249687_6251160_+|C39-family-peptidase	gnl|CDD|239109	cd02549, Peptidase_C39A, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.	8.06138e-13

Protein sequences

>NZ_AP019860.1|WP_151970241.1|6230890_6233704_-|HEAT-repeat-domain-containing-protein
MGEIGESEKVILALIPLLDENKNYDIKLSATEALEKIAKKATLPFISLLQNKKFFVRRYAAKVLGEIGEKAHPAIPDLVLLLKDKSSNVRWEAVKALGKIGEKSYSTVSYVIPLLRDQDSVVRREAVKTLGMMKESAYPMVQYIIPLLRDGDPNVRWEAVEALGVIGKKAIFSLISLLEDKDQHVRKAAAIAFGRIQESEFSTEECIIPILENLSKNQDYDVKIFATISLINMREKAISSIILLSKDSDVIWQVLEALREIGEKTYSVVPHLIPYLIHLMKADTDVTQDVIKAIGKKAIPSIIPLLKSEISDVRCSAAIALVMLGEKATSATPYLSSLLKDEDSNVRRYAAYALISLLKYENSDVIKEAKKVLGLKKNAYPMIHLLENEYFERNALEALAKMGEKAVPYLIPLLKDPDVERSVIEVLGNMGEKAIRQIIPLLQNEDKNIIKNAAEVLGEIGEKAEKVDNVVSHLVPLLKNENSDVVCSTLLALGEIGEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAEKAEKAVSALVLALKDQDWRVRRNAAWALGEIGEKAENIIPKLIPLLEDQISNVRHSGVEALGKIGEKAVPDLILALKDQDEDVRKNAARALGKIGEKAEKAVPTLIAALKDYDWRGRGDAAKALGNIGKKTEKIIVALISLLEDQDYYLRGDAAEALGKIGKTTLAIQHLIPLLQNDSKYVRSFGKEALEKIKRKGKEAVPCFIPLLRDKDFWIRYSALKALVDMGEKAAPSLIPLLKDSDKDVQNSAVYALKEIAEKNSLKTVIPHIRQFLQIEANQKVLGLKVLNSCVWHAYLEEKKNVFTQEDIQILSKSEDYEILNTVAAIYAWQGNTKKANMYSSKTYKETAKRVKLLLEGKTPKQVEIELKENQ
>NZ_AP019860.1|WP_151966415.1|6229294_6230536_-|IS4-family-transposase
MHRKNEKDFTRERKLPFSRLMVFMIRKSIKSIQNRLNEFVKDLLTNFTTVTSGAYTKARKKLNYTAFIELNKQAVVETLYEDEDYRKYKGFRLCAIDGSKVRLPNEKEIEEHFGTIRYKNKNISVEGSHAFATVSVLYDLLNEIAIDSEIGHCKKDEELFAYKHFQHANENDLILFDRGYCSYTLLAHLCKKGINFVVRCPVNSFYQANKMFKQKIESCITTIEPPDDKKKLVNDQSLPSKISVRFVRVMLDTGDVEVLVSSLVDEQLYPTDDFKELYWFRWGIETFFDRIKNRLDLENFTGKTTLSVQQDFYATIYISGLESILIEDAQDILDQKTSSNKYPQQVNKSVSFNTIKNYALDLLFENDSDLLFEKLTQLFLSSPTCIRKDRPRPRVKSPRKQVNYYKRKRKPTY
>NZ_AP019860.1|WP_151970240.1|6227611_6229087_-|hypothetical-protein
MQKYIVTLLFLSIVGFTTAQNHTETINATNLHVKSAESPTSLLLEHESGKWKLTSSGPHFYLSNMKSGEDLFAVKSNGCIAIGTNTNLNGVSHRLFVDGSIKASGNIFSQNINSGLIKASTNIIAQNKIGIGTDSPEGVLHAKSTENYASLLLESNLGKWKASSSGTNFYLSNMKSGEDLFAVKSNGCIAIGTNTNLNGVSHRLFVDGSIKASKDIIAQNINAKKVNITDLTLGTGKIMSPTELSFNTPVGKAMTIDKDGWVAINAQPSDKYTLTIGGHTKINNNLNVSGAIGVGTTDPKANLHICSEKHFTSLRLDNHKGNWRLASSGGSFYISNYTTTPARDLFAINEGGNVGIKCSPHSTYSLAVKGKVLAEEVLVALHQDWPDFVFDDSYNLTSLEEVEQQIKKNKHLPDIPSGKEVKQNGIQLGAMQGKLLQKIEELTLYTIQQDKQIKSLKVEKHQMKERMEAEKLEMQKRLEKVEKLLHGLLKK
>NZ_AP019860.1|WP_151970239.1|6225875_6227564_-|hypothetical-protein
MKILFLFFLFPISLFADYYGPVKTVYKKIPTETYLGKKLFDGAQKNNTVTRKKVQLIPGFHTTQSRIRISRNIPTGISVSGISALYEKRSAKYKATAHFPDTTLDITNVCKWIVSHKSYGGIFQGNFEAKTVPYDIEIDIVAAFAVEGVVFEVKFPVKILKLGITSIQAGIDKEISGAIEKAEANGHKHIEVRGTNSFTSGTAPTTPHIFLGVKTEPISPDNRITGIAIVAGGKEIPISPGYKVVVDLNKGCGDGTAYVYLCIKTGGNNPIENLIAAKDAMGLPEPGYTRINLSTNFGCHQHIKESIQSPLREYHGQDIYIFVKGGNEILAIPYGNDEDYLHKNIEGYVNQKLEILKGEVEKAKETAQTIQRELQKIEKAVSNVVGYETNKWDKREEIYNHENEDGKGRWTVAWGREITETDLAEILVAIGIDIYGGGGNATLTKIEEIGIESFEKITTNTIETFSLYLEKTARQIADEMLNDIDNLVFDVMERFFKALVDGKDPDEAVRSFVNGKINSYGSIRIHVRAGVASYSGSNKLFGQTASKTFSWQPFVAIRVVRD
>NZ_AP019860.1|WP_151970238.1|6223694_6225851_-|hypothetical-protein
MKTVYFILFFIATNFLASQEKQLYLDCGFETGKNLKVGVIHKSLNDIQTTQRFGSSKTELMAKKQIFFKPGFHCKNLRAHIDKSDIHRIAIFGPDSFYENEQPQFEAYASFSENEPCSYRVTDKCEWMITPNGYAKLENKVFQNQIKKVFKTLSTDSRDLEVKIVAAFNGVSVKKSVTVYRKGITHLTVKWDSKEIPEGYKSTKDLNTGAGGEYIYLCYKVETPENPDDRITGLFLVAGPENVSAPPGYTLRGHDLNAGAGGSYIYMAYKKGGYNPLQEIEVLTRHEESTKGYEKIPLDLNWSVGGEYLYLSVKGGEELIYQIVGEKSDYQKQSDWDAFTGWADEKGEHLGNFVKATFNIKRHLRVTNDYLADRSKVLNTYIDNRFRTLEDSLRTELKAGGKYLDERIRAVENFDLKNYDPQNEWEHGMKFLKRRKETLKKASMVEFNRLEGTLLRELLNALMDRDTEIPKKFHQNTDSQGKTLDGHIIYYVNGVATTEKKAQTSMRMLADTLQHPIRVIYNKSHDDPDGYNTGNKFYALDFTETLSDLDWYNLAPFEETLRVLSKLAQEFLSFDVTIPRDPRRLLDKIYVSNYCTRRVAGLMYEKAQKGEPMTIVSHSQGCVIVRNACFIMQILGYRPWVKKHLRWVAVGSPVNENFNHPRPPEQENRYYRLVDNDDIVVNSVGMSGLSGWSFDAHDFNEVYIPRLRGIMKDLDMIK
>NZ_AP019860.1|WP_151970237.1|6221990_6223661_-|hypothetical-protein
MLNLKNWPLLCLLLHWSIFLPAQDMCKTVDLSSENFTEQTHQQEEQSGLSLVGAVKKLWPKNERVLHVRFVGIRNRILEQQIQKIVEDNWEQCCGIDFVFDNSSKAQITVNISSSQGNNSYVGTDSKGKNPSMNFLFYYYDKKSKKTKLRSDVLREIGGKKVIPYDSYTYGTILHEFGHAMGFKHEQQSPNFRVEWDEEKLFNYYKEIYPKKEDEVVRSMMSINMTKLKGSSFTRRVYGKVQQINSDSSNNQGYNTGPFQSEIVEVRFKPMHATTDFDPHSIMCYPINLHLVKDYSKYRLGILDGKHEEDLKGWRNTLEMRYDFRKEGLEIDKDAEIILYRNNDNIYIRTNIDDIRYILMPNSKSGNLDIYPWWGGRHTLSSVDRYFANKLYPYTRSSDNHRFVQRELYRAFEEILSRQPDINEIVECSNYMHDYGLLEMRYLIAKKATKKIKSFYLMYTGSEASDEFVEDSRQQLVERNMDDVVIKKLLKNVTIRSQEQFGEQQANIEKAVNIDVSTFQNAPGGEMMLKARRKITLKPGFHAKKGGKFLAEIHKE
>NZ_AP019860.1|WP_151970236.1|6215564_6221918_-|HEAT-repeat-domain-containing-protein
MKKTIVLILILISFCTAENSDIKYWVNQLEQGSRNEKIKAIKELREKQVKSILPQLEEARRKALDANDDKLTLLISKVIRSIELSSKKTLQKKTQVSIRSRATNPPKKLGGLTILGSSPDFSSRQYGKCHAIVIGINNYEHFTSLAGPCLDASEVARVLENRYNFDNVHLLADTKPSTTINFKTQQVTKDLIKNKIEALRQKVKSDDALFFFYAGHGVPGYLVASDSSKDGLGKPNVKSMMSLTKIAKNLKSLGARHTLMVLDCCFSGSLLEGEYRPDFSDLANDEFVTPGGDNLTRVFKRQSFQIITAGTGDEVVADKLDEKSAIYAQQFKDSRGHSPFTAVFLQAIQGLTGRDDGVVLASQLGFYMMDTLVNDKRIKASQAPRYGTLGGNGDFMFFPTEKVLNPKMVAPLYLNGIEFASFRRSGCEALENFIDGQAHKKDQTALVKSALPHIAKLLQDEQTFPRMAALKFIKNVAQQHAHNIKEFSNVIPPLLKLAKSRNKFSSEDDYFKVIDCLGFLCIHANQEFVNVFKNYCNDQDKEWKEYKKDKKLPLVVRKERQKQNDLLQTLSTTTKKLQEQAKIYWQTIKIYQWLHTEGKIKIEFYKNGKKTFLLSTEDEEKRLKAFHLVKDEITDKEFIKYFETNDTNKVIREEVLLFLAKAKRDLPILFKLLQESNEDTKKQIAKDLEKIGERAFFAIVKKLDNSKNQTSRKLLFCFVSWQKKSLFKLIDQLSQEDQDFFIPVLAKKIFDSLYEIIINRNESEKIRSQAASIIKKSEMIESFLTKFFISINERDSFEKQIAIDIIISQEKYSTAKILLEVLKDQDPDVRRNAVEGLRNIKSIREAVPALIVALKDQDVDVRKSAAQALGNVGEKVKEAIPALIVALKDKDSETRSSAAQALGNIGEKAEKAVSALIVALKDQNVSVRGHVTQALGKIGKKAEEAVPTLIVALKDQNEGVRMDAAQALEKIGEAKEVVPALLILTLKEQVWMRIRAGKALESIGKKAIPALILVLKDKDSKMRYCAAKALGKIGEKALSAVPDLIFTLKDQSGDVRCCAAEALGKIGEKAYSAVPHLIPLLQDEEEYVKETVAEALGKIGEKAKEAIPALILALKDKDSKMRYCAVEALGKIGEKACSVVPDLILALKNEDPGLRAHAAKALGGIGEKAHSAVPYLIPLLQNNHAGVRSSTARALGKIGEKAYSAVPHLIPLLQDVYVRTEVVEALGEIGEKAEKAVPALILALKDPDEVVRSSAAEALGKIGEKAKEAIPTLILALKDESKWVEKSATEALGNIGEKAEKAVPALILALKDPDEVVRSSAAEALGKIGEKAKEAIPTLILALKDESKWVEKSATEALGNIGEKAEKAVPALILALKDPDEVVRWCVAQALGNIGEKAHLAVPHLIPLLQDEEEYVKEKVAEALGKIGEKAHSAVPDLILTLKDQSGDVRNSAAEALWKIGEKTEKLEKVAPALIFALKGRGRSVGVSVGRTLGKINNIKNIEFVVFLLKDESWEVRSYAVEALAKMGEKAVPPLISALKDKSSFVRSDAVNALSKIAKKAGKVEKSVSALILALKDPDEVVRWRAVQALGKIGKKAEKAIPTIILALKDQEGYVRKSAVKALSNIAKKAEKTQSVVPDLILTLKDENWDVRDSAALALEKIGKKAEKAVPTFILALKNQDKYVRSYAARALGKIGEKAYSAVPDLILAFKDQDKHVRYCAAEALANIGEKAVPPLIVALKDQNRDVREFAAKALGKIGEKAYSAVPALILAFKDQDKWVRSSAAEALAKIGEKASKAIPTLILALKDPDEDVRKYTTWALIEIAKKARKAVPLTLVLKDKNFIVRSYAVEALAKIGEKAVPPLISALKDKNFIVRSSAAEALGKIGEKAHSAVPDLILAFKDQDRHVRYCAAEALAKIGEKAEKAIPTLILALKDQDSKVRGATAWVLGEIGEKAEKAVPGLIFALKNQDLSTRRYAIWALVKIGKRVLLPIKKFIQTEKDEVAVASGLQVLNFYMRKAYLEEDKFAQEDLELLSLSKDKDHLDTVAAIYAWQGNVKKANQYTTGTSKRVKLLLAGKSPKQVEYEMQHEAWGDDSEYAMENEDWDDGDENWDDEEW
>NZ_AP019860.1|WP_151970235.1|6208072_6215209_+|HEAT-repeat-domain-containing-protein
MVYGKRYLQNTLIFFVLFNIAFAQSNKETLDEKLKLILKYLKSPDTQLHFSALAELEKIGADAKKIRPELEKALTSADGHSKHAINYAVRRIEFINKKFPSKIFPNASQTKRSPASRISKNVGGLNILGVSNDFRQRLRYGKRHALVIGINKYNKYYSELDGPNYDAGEVASILADRYGFENVTYLCDTIPRNVYRQNELKERNPRRLENRKSYTTKNGSETIVVAPLVTKGVIEKYLTETFAKVGPNDAIFLFYAGHGVPGHIVATPKNKDDDGYISLTKLALNLSEKNAKHTLIVLDCCFGGSLLQDKYKPRLKGYNNSTFQFGTGENIDRVFARRSFQVISAGTGNEVVADKLSASTKYAQLTDSSGHSPFSALFLQALKGLVGRDDGIVLASDLGYYMMTTLTNDKRLDAKQTPRYGSLGGDGDFMFFPAYKVLNPKLLAPLYLSDKMYADFRSSGCEALEKFINTYSRQDQISLTKSALHHISKLLEDEEVGPRKAALNFITEKATKYAKDIKEFNHVVSALTAYFSYNDKKIDLNSFFTLQNQQDETDLYEVINCLGILHKDANKKVVDILEAYNKKLRLQWQELSKDKKKPQSVKDKLEECKELGSLPDESFQKQAHYYYQVVNVYRWLTTIGETELKDYENRMNLFLSNTEDKERKISFNKYKEEFSKDDFKKYFMVRDQYIRKEVLTYLAAKGTDLTILFELLKKLDKREDIKNDIAKDLENVRVRERAFLKIVEEVNNQSEKSKKLLFAFRSWKKKPLFELINKKLSKEDQDIFLPILAEENFNSIYSLMTDKYQNKKDIRSKAAFIISKLNKKERFIAHFFTSINERDLFDKQVAIDILTSKETVTEYSTVTILSLLLKNENKNLRNSAAKTLGEIGEKAYSAVPDLILALKNGDPGLKAHAAEALGGIGEKAYSAVPYLIPLLQNNHADVRSSTAWALGKIGEKVEKAVPDLITLLQDEDEDVKKKVAEALGGIGEKAHSAVPHLITLLQDEDEDVKKKAAEALGGIGEKAHSAVPHLITLLKNSDIQKHAAEALSKIGEKAVPALADALDGDYDVRISVAEALGDIGEKAVKAVPALILALKYEYLYARESAEEALGKIGEKAVPALILALKDQNKNVRRSVAEVLAVIGEAEKTVPALILALKDNDEYVRRTASWGLGKIGEKAYLAVPHLITLLQDKDEDVKNKAAEALGEIGEKAHSAVPHLILLLQDKYSWNRISAAEALDKIGEKSHSTVSHLIPLLQDKEVRADVAEALGKVGEKAVPHLILLLQDKDKEVRADVAEALGKIGEKSHSAVPHLIPLLQDKDKEVRADVAEALGKIGEKAHSAVPHLIPLLQDEDEDVRDKVVEVLGKIGEKAHLAIPHLTPLLQDKDENVRNKVVDTLGNIGKKVRSIVSYIIPLLRDNHASVRNSAVRSLGMMTKSEYPLVQYIIPLLKDKDKWVRKNATETLRKIGEKSICFLIPLLKDDDESVRNAAVIALGKIGESVFSTEECLTSVLEHLSINENWEVRVSAAELLIRMGEKATSSIILLLKDKEVCIEAARALERLGEKAHLVIDFIIYIDTVSISPDELAEIFQSIEKRMITSIIPLLKDRNYKVRCSAAKTLGFMKAYSAIPHLIPLLQDKDYFVRRSAARTLGFMKAYSAVPHLIYLLRDDQCHSMQTDAAEALAEIGEIGEEAHSVVPDLIPLLKDEDLIVRSSAAEALGGIGEKAYLAVPHLIPLLQDRDEDVRNSAAWALGKIEKKAHSSVPHLIPLLKDKDKKVRVDATKILGRIGAHSAVPHLIPLLQDEDKEVRAYAAWALGKIGEKAHSAVPHLIPLLENKDKEVRAYAAWAFGRIGKKAYSAVPYLIPLLQDEDKDVRIDAAEALGEIGGKAEKATSDLIVALKDPDKYVRYSAAEALGKIGEKAHSAVPHLIPLLKDSYTQEVAAEALGKIGKKAEEAVQHLIPLQNDISMALVEKVLEKIRGNIISTLIFHLKNKSLNTRQQATEALGKIGGKAHSAVPHLIPLLKDSYTQQVAAEALGKIGEKAYSAVPYLTLLLQDEDKEVRIEAAKALGGIGGKAEKATSDLIVALKDPDKYVRYSAAEALGKIGEKAHSAVPHLIPLLKDSYTQEVATEALGKIGKKAEEAVQHLIPLLKDSYTQEVAAEVLGKIGEKAHLAVPHLIPLLKYDSECEDNVREKAAKALRKIGEKKIPQIVPLLKNKEDFWIRYLALKELVNTGEKAVPSLTPLLKDSDEYVRNSAVYALKEIAKENPKTVISYTRRFLQEEKNQAALELLNSCVWQAYIEEDKSVFSQEDIQLLAISEDYNILNTTATIYAWQGNTKKANIYSSKAFRETAKRVKLLLEGKTPKQVEEEIKTKNSF
>NZ_AP019860.1|WP_151970234.1|6206424_6206895_-|hypothetical-protein
MLLPQDHHFEPRPQILEPFSDIFGMNSLLSSEYIGISIWAKNTSPLLKDLDRYVKIVTGMALRKLREEALPSIRYFLQKEKDKQAIESALQILGEYLQAAYIKENTSSFTQVDVMLLSKSKEKGHLDTVAAIYVWQKNAEKAHMLPLKQKRIPQKE
>NZ_AP019860.1|WP_151970233.1|6205222_6206125_+|hypothetical-protein
MSKQNNTETFYKVITMFLLFFPLILFLPLLTYGVPNQTTTLILLICVSWNFVWHLLWIKYEKVTMAAKIIILLAPICFWFDICFLGWRTYSQDICRGRMRCEFADMLFFVRNGKNTHLINKWLGETAPHWTHSHIGGSPFSLVVDGNERVNTHSIVHQYYLPRILKLLPHDNARKQVLQCVCDSQNQLRFYQGLLMVCVMEWGFPEKKTAEEWWQKHQHFFIHESDGYEAAKTVVNWRLKIEEITRKKFGLRDRGTEVEVQLRAIEYLENGYRTKEKSFVREIAEDIIKPYHPVEPQWWK
>NZ_AP019860.1|WP_173013502.1|6238602_6240132_+|IS21-family-transposase
MIKMDMYGYIRFAHGKLGKSINSIHRETKKARETIRKAIKGIEPKYRLTKPRRKWVMGPYMEIITKWLEEDKKVPVKQRHTAKKIYDRLVEEYSFKGAERTVRSAVREVKEKIGILNNESFIPSDPEKRHGSEVDWGEAYVDIKGSRVKVYMFCMRAKYSGKIFVKLYPTMAQECFFNGHIEAFAYYGGVFDELVYDNLKAAVQKVLRGRQRIEQQSFISFRSYYCFSPQFCSPAKGNEKGGVEQLVKYARRNFVTPIPECNSLEEINNKLLEQCLAHIMRQKNKEKITIGEKFQQEKSRLLKLPHSPYNNYKLIEKRVDKYQTITVDHNKYSAPYDYVNKNVVVELGLSDVRITYQSKLIARHQRVYHRGYWQLDPWHYMEMLRKKSRAFKSSRILTTIEEKWSPVVKELWNQQRLKYGDEKGTKEFIDSLLLFKNKDYGDMISVIELAIENNTFCKASIQNLYDALTEKEIVAGEASVDHIKAIKEFDLPQPDVNKFDQLMEGQNAN
>NZ_AP019860.1|WP_151970244.1|6240121_6240814_+|ATP-binding-protein
MPTKTNLQVLLRELKLKAFQENYEQYISGKVNLEKTLLKLCQLEREKRFSAKVKRRIKAATFPKVKTQSMLDYKKAPKLPKQKVQELFTTEFIKQKENVVLVGDSGGGKTHLAIALGIEACQKDISVKFYTASQLVNKLLSEYKEGRIEKFMMKLRKYGLLIIDELGYVPFSKKGAELLFQVFSDRYEAGSIVVTSNLNFSEWTQVFIDKKMTTALLDRLTHNATIIKYN
>NZ_AP019860.1|WP_151970245.1|6241163_6242870_-|protein-kinase
MNDLEFKSLWTKVIDKKILDSDKISHTYKPNDMTFSNDITVFPTHQTFSEQNTLVIKNIDQTFSGEKTVGAQTDETFSNEKTTALCLESPDINFQKNDQDIQQVDAQTDVISQAWQNKLKRKVSIKKIPSTSHNNKVLTEAQVTAYLEHPNILPIHNIEENAQGQTLLVMKLLEGYSWSQLLHPQTEEQKNKSKQYNLSAHIRILTKVCNAVRYAHSKGIVHCDLKPENVLIGNYGEVLVIGWGIAVSVDNDVKKVSILYKDSICEPMGTPCYMPPELAEGRGKDISTTTDIYLLGAILYEILHKSAPRKNKNLWNTLLEAQSGTLPKFDGKNPQNLINTCQRAMAKHTHLRYQTVDEFQMEIESFLSNQESVVISDEAKSNLDNCLERMKNLNSEIVKTKKKSFFTKRQEKQKEKLKAHLYDMFIESIFGFKNASEIWQENVEAIQGEITARLEYANFAFQNADTNLALSQLEKLDELDTTQKNKEEISELYEKIARDKRDVYSKINHHTHGVLSVTISIIGACILFVVFFHAFIFFSKWIPSPVFEVSIFIAIIITLIKVASIKKR
>NZ_AP019860.1|WP_151970246.1|6242899_6244630_-|protein-kinase
MKDSEFKSLWTKVVSTELLKGNEISTTYKSKNMAFSNDTTVFPDKVTETFSSSETIAPHNPNNTFSEDKTIAQQNETFSKEETIALASQSQQIRVDSNSGYQDFKEINRGGMGVIYCARQSKLSRDVAVKKMLPEAQKNKFLAESLVTAYLDHPNIVPIHDIEENENGEILLAMKLVKGMSWKQLLYPKTPEEKEKAKPYDLNVHLQILLNVCDAISYAHSKGIVHCDLKPENVMIGDYGEVLVMDWGIAVEVTENVQEMRTFHKNGIQSPMGTPCYMPPELAQGQGKDIAYATDVYLLGGILYEILYKKPPRRGKNLWLTLLDAKHGKMPEFSDSKPALLNSICRQAMLKFTMYRYDNVDKFKKRIENFLSHQESIRMCDRAKSCLNKSQVRLEDIECEMSKLKDEIKGLRWKLAVGTVKEEIDTATKKIQEKNKDKLLVNDLFLESIFGFKNALKLWSENNEAIQGEIQARLEYAKFALGNGDARLVTSQLENLNSKNLTLEQRKQIKEIQDKIAGKLSIYFTTQKNVLSIITMIPRFLCYFFLSLLFVIFGEILSTLHIPAGRTGQKTDRNGK
>NZ_AP019860.1|WP_151970247.1|6244677_6244983_-|hypothetical-protein
MKKFSVLFLFVLIAFSNVLAQSINSSAVLEQLQSPNVKQRFSALAEIEQLGSKAKKLRPSLIKLQTKTLLEGKTPKQVEETIKAEEKRQNEDTDMWEEEAW
>NZ_AP019860.1|WP_151970248.1|6245291_6247097_+|hypothetical-protein
MKTIVIACLLFSLTTMAYAFKPKTHVYLAEIAIEDALDDGKVTIHYVDYEGKKIVGAIGEYPVSSEVLYALRNHAAQYRAGVLGPDAYPDIFTGQQAIHPKYAGKWFEYLWSRAQSADPAAKAFVLGYMTHGAGDMFGHTFINHFSGGPFSFAEYNAVKHFVVESCVANRNPPLKTYNASIAGVEDFIYQTLINAHPDSHLRKYLLKGEGTDLSLPLYASKTKSWLERYIQDYSNWIQKRNEEIDGLKKKNQREREKIIPDIFAITSRLAEIGVLEADKSTFINARIHAVNYAREWIKDIDRGLKVWPKVSHEIATALMFDPSGTNLEKAKKVAQDFLLDHYLSMIGAPDVVGDVIQEALKQIAALIEFIMEKVPALKVILAELEKIKNDFLNYLCKKAFGMSAEEYSKYLKSPETYFNDVIHLGQGSARPTLGEFYKNYLHLAKSSDYFDWQKFAPAYNTVTISKLILLDQSTINQLLQDLGTYRRLTTANIMLGFIENLDADNQWACCTSKMVFAQDMEFYQRIFMFQAGETKINVPVQDSLDLNQFFAGKFIYKANSKIKAGGGFIIKEQKKVVFKAPEIEFTPGFEVQPGSELSADQ
>NZ_AP019860.1|WP_151970249.1|6247235_6249626_+|hypothetical-protein
MTKWILLFVTVTSFLTAQSFTHVNVHNPNSNSGLVTVSGTGAGWTHAAIKLHSGQSSRGTGIYGTYGSNSWYFGNPYRSHDRFIIGRVSGRDYREAADFNYALLTVFNNGTLRAKALEVVGPHLKLEYTSEGSKIHSAFGASSPRNMILDINGGTSSSGAMIFRTQSKERMYIDRGGLVGIGVRPAGGYILKVGGNANFMYGVKVGGTIEAGKLTLNGLSAGRTDEGTVVSSAFGGSSALDLIFDVTGGTSQHGAMIFRTQGADRININRGGNVGIGTKPTNDKLTVAGNVNASGSITAGGLLKGGKLELNGFNAGRTAEGTVVSSAFGGSSALDLIFDVTGGTSQHGAMIFKTQGQTRMYIDRGGLVGIGTKPTNNVALNVAGNVKISGNIDNAQISKLQTDVSNLQAGFSSVPTFVNVNSDTQNSSRGIHFNKNSVTTAKIYFYGSKYDPNFDYEGTDPLEEELEEDQKSYKKQEYVGVSIDGNDIIKAHRHKVTIAQPTDVTSSLTVTGTLTVDSNLTANKMIIAKSDIKTSKSVIAPIGRFDNLSINTFGSSNLGGYVDDSNNFILRLASKNKSNIYFSKIASGTGYNMKIAHDTDKLVVTGKDPEKATFAVEGKIEGASVTSKYVASPHRMHISAEEHLFLLTKKPEHAVKIGTEWGGSGDLDVYGKLSVGSRINVNGSLCSTSAFIKGQLQAQSVLVKAAVQWPDYVFDENYKLTSLEELEKQIKKQKHLPGIPSKEDVKKGVDVGNLSASLLKKIEELTLYTIEQEKKMKQMRKQMLEMQRKLNKISEK
>NZ_AP019860.1|WP_151970250.1|6249687_6251160_+|C39-family-peptidase
MRHMIPLCVFFFVTSIFISTQEIKNFPNYEQPDGFSCGPACASMLLKYYNISAGIGPLKTKADSRILEEEGWGYTTPDDLEKAIEEYDLSVTRKKGTIADLKNNAKKGIPTIVLVRSGVAMWHYVVVIGYDEINDDFKISDPGGTGIYHIRDYLYSNLYTPSEALESCWRYETAMWGEVIPAPVQLTVLGLIALLNTQAPQNTMIYPSFAWPTINEFKNKETPFSFPENKIYDTICHKSFYFHIDESESSIFGKTGNETWLRDTQTGNMKVKRVNRVGNHYTFDIQLPAYAYYDRKTFIRVGGPKKENWNMVFVSSFRYKCLVKEGNIIAGVVENFSSDLKTKNGHGHDSFKFARTEVQKKIVNKLYTHSVADFRKEVLSKYPQVVAECYHKYNLIPDDKESYFRSLLEKHGVDYIDNEIKKRQQTPPSKITLQNKTVHSFGKLAAADSITINSTTMTKDAHVTISAKTVELQPGTNLQQGSFVKITPKN
>NZ_AP019860.1|WP_151970251.1|6251176_6252850_+|hypothetical-protein
MNAKFYIVMIIFMISLSAEYVGPNKTITKKIPTHMKLQHKTISSGHHLTLAAQQTVELLPGAAVAPGGSLEVKVSSNIPREVSITGPVELYENSKAQYKSTVIFPNGHSKDITNNYKWHVSHSNYASIHNGLLTTKAVKRDFFIDIVISTVYEGYPIEVSFEVKILKEAYTSLRLGWSHDVDKAAHMAQADGHKVIHVDNGLTAGSGPDTPWVLLGGKKARVAPHQRITGIAIIGGPDGITGPPGYTYVGDLNKGCGYGTAGVYLYYKHGYHSNPVSDLKIIKSTTPPQGYFLINVNLNFGCNRYIDKLGSSNDQEYHGVTMYLSALGGEYFVAETYGKDSDYAYRRVEGYINQRLEVLQREFKKAEKKFIQIKNDAGAFFDKLENLSTYETTKWKVRDRIRKGGWRVAWGREVTEVDLLEIAGAIGADVYGGGGTATMSVLEQIGLESIEKLSENVVDEFSGYFEGQLESLMDEVTDFAQQIILTFFKALIDGKSPEDAIGDLVTALERKAQEAKGFRIEFKAGVAEYSGKNKVAGVTLSPTISWQPYIAVRLVRP
>NZ_AP019860.1|WP_173013503.1|6253011_6255126_-|serine/threonine-protein-kinase
MKRSDSNSSLLLSITLFFHNLFFYCFKLFYTIYLRLSQWAWTDRDKFLAESLASAYLEHPNIVPIHDIQQNDNDEILLAMKLVKGTSWKQLLYPKTEEEKEKAKKYSQQTHLQILVNVCNAISYAHSKGIVHCDLKPENIMIGDFGEIYVMDWGIAVDVTDNIDDKRTFHKSSITEPMGTPCYMSPELAEGRGQDISYATDIYLLGGILYEILHKKPPRKEKSLWLTLLAAKKGKMPVFDRAIPEELIKICQQALAKNATQRPQNVNSFRIAIEDYFKHYESIIITQKAEKILEKCTDKKARGMKKTQLYEMYTKAITGFEQAINLWQENENAQKSLLKAHNLYTKSAIANDDFGIAKTQIEHLHETKERKALQKKISKKEAVKFGISIVVKFAQFGILSIFILMSSIIIAPFFVNVKDIENIDYLMIPLTVMICFVTKSTEEAIKAKTQHTANIWINTIISSFLCYICVGVSPIWASKYSILLGKYSTVLFWIATITFYIFMMLLYSRTWIKVSFSKRLSIVLTQIGPLISFITILVLFEIISNVFTISILQSKIIMLVITTLFSSIGAGKTVEFIVKCKQPWWKQVLFIIPMVLSVAIFCAALTICFVLLVSATGGEGAQAILALTVIFGGPLIGILSIIIFYNLYFRIYNVWPKKYRFKEKFWMMLYHVFVFFSLQAFYLTGIFLFSTKGKALLQSIKNYF

Crispr_ID: NZ_AP019860_31

• CRISPR_ID: NZ_AP019860_31
• CRISPR_location: 6477736-6477886
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP019860_31

Consensus_repeat	Method
GAGTCTTCAGAAAATGTATCTGTTG	CRISPRCasFinder

spacers of NZ_AP019860_31

>31.1|6477761|41|NZ_AP019860|CRISPRCasFinder
GAACATCGTTACTTGCAAAACTTTCCTCTGGAGAGACAGTG
>31.2|6477827|35|NZ_AP019860|CRISPRCasFinder
GCGATGGATGATCCGCGAGAATTTTGCCATCCCCA

CRISPR arrays and Neighbor proteins around NZ_AP019860_31

CRISPR arrays

The CRISPR arrays of NZ_AP019860_31

>merge|NZ_AP019860|31|6477736-6477886|CRISPRCasFinder
GCATCTTGAGAAGAAGTATCTTCTAGAACATCGTTACTTGCAAAACTTTCCTCTGGAGAGACAGTGGAGTCTTCAGAAAATGTATCTGTTGGCGATGGATGATCCGCGAGAATTTTGCCATCCCCAGAGTCTTCAGAAAATGTATCTGTTG

>NZ_AP019860|31|26|6477736-6477886|CRISPRCasFinder
GCATCTTGAGAAGAAGTATCTTCTA	GAACATCGTTACTTGCAAAACTTTCCTCTGGAGAGACAGTG
GAGTCTTCAGAAAATGTATCTGTTG	GCGATGGATGATCCGCGAGAATTTTGCCATCCCCA
GAGTCTTCAGAAAATGTATCTGTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970351.1|6491043_6491223_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970340.1|6467744_6470999_+|hypothetical-protein	unknown	unknown	gnl|CDD|372604
NZ_AP019860.1|WP_151970345.1|6478135_6480085_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151966752.1|6486583_6487834_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970353.1|6492525_6494223_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970339.1|6465917_6467711_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970336.1|6460786_6462565_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970334.1|6456485_6458141_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970337.1|6462579_6464820_+|hypothetical-protein	unknown	unknown	gnl|CDD|274618
NZ_AP019860.1|WP_151970342.1|6471879_6473973_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970352.1|6491304_6492357_+|hypothetical-protein	unknown	unknown	gnl|CDD|239807
NZ_AP019860.1|WP_151970347.1|6482465_6484010_+|caspase-family-protein	unknown	unknown	gnl|CDD|334197
NZ_AP019860.1|WP_151970341.1|6471152_6471674_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970338.1|6464960_6465482_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970346.1|6480420_6482316_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970349.1|6488046_6489000_+|hypothetical-protein	unknown	unknown	gnl|CDD|223604
NZ_AP019860.1|WP_173013514.1|6484135_6486094_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970343.1|6474055_6476020_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970335.1|6458169_6460293_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970350.1|6489004_6490981_+|caspase-family-protein	unknown	unknown	gnl|CDD|334197

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970340.1|6467744_6470999_+|hypothetical-protein	gnl|CDD|372604	pfam13435, Cytochrome_C554, Cytochrome c554 and c-prime. This family is a tetra-haem cytochrome involved in the oxidation of ammonia. It is found in both phototrophic and denitrifying bacteria.	7.45363e-11
NZ_AP019860.1|WP_151970345.1|6478135_6480085_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.58913e-70
NZ_AP019860.1|WP_151970349.1|6488046_6489000_+|hypothetical-protein	gnl|CDD|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	0.00839153
NZ_AP019860.1|WP_151970339.1|6465917_6467711_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.91166e-63
NZ_AP019860.1|WP_151970336.1|6460786_6462565_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.8055e-64
NZ_AP019860.1|WP_151970337.1|6462579_6464820_+|hypothetical-protein	gnl|CDD|274618	TIGR03508, decahem_SO, decaheme c-type cytochrome, DmsE family. Members of this family are small, decaheme c-type cytochromes, related DmsE of Shewanella oneidensis MR-1, which has been shown to be part of an anaerobic dimethyl sulfoxide reductase.	0.000154009
NZ_AP019860.1|WP_151970342.1|6471879_6473973_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.18481e-65
NZ_AP019860.1|WP_151970347.1|6482465_6484010_+|caspase-family-protein	gnl|CDD|334197	pfam00656, Peptidase_C14, Caspase domain.	2.21749e-12
NZ_AP019860.1|WP_151970346.1|6480420_6482316_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.15469e-86
NZ_AP019860.1|WP_151970350.1|6489004_6490981_+|caspase-family-protein	gnl|CDD|334197	pfam00656, Peptidase_C14, Caspase domain.	5.64064e-13
NZ_AP019860.1|WP_151970352.1|6491304_6492357_+|hypothetical-protein	gnl|CDD|239807	cd04280, ZnMc_astacin_like, Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.	8.83582e-27
NZ_AP019860.1|WP_173013514.1|6484135_6486094_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.35069e-65
NZ_AP019860.1|WP_151970343.1|6474055_6476020_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.04428e-69

Protein sequences

>NZ_AP019860.1|WP_151970343.1|6474055_6476020_-|protein-kinase
MDNDTFRSLWSKILEQDSSSKHSVRNTYKSKEMTFSHDITVFPAQQTFSDDGTIHAENPSPTDTFSQDVTIPPQESTSTFSGDSTVDSLEDTAESQNASDTFSEDATMDTEDHTKKVTFSATETTAPANAPQTKVTFQNELDYQNYQEINRGGMGIIYRVEQTKLKREIAIKKTLPQVEKNKFLAESLVTAYLDHPNIVPIYEMDQSSEGDILLAMKLVKGISWKDLLYPQTAENKEKAKEYDLQKHLEILISVCNAVNYAHSKGIVHCDLKPENIMIGDFEEVLVMDWGIAVDVRENPDERRTFYKIDIKTPMGTPCYMSPELAEGRGKDISVTTDIYLLGGILYEILHRKPPHTGKSLWLVLLAAKESKPVSFAEKIPLDLRQICHKAMAKKPSDRYQSVTDFKQTVANYLKHRESISLANKATEFYNSAVKYINTNKSQESGYKLKYLFFELPGKVLFPYWYFYASKILKFVVGMAAAVLMWVASLNSNVPISGIPFLIIAAIIANIVFLIVQTTLWLSGKENVYVFPQSKLSPSLVYTNLIRAMSLYEQAINTWQDNKSAQKNKIKLHAQIANIALDFKDIKLAKVHIEEIQKFDLASIKKLHQKFHQAKIEGIRERSAVNIYKIISSVLFYGILLALLSHFILSYVIAQ
>NZ_AP019860.1|WP_151970342.1|6471879_6473973_-|protein-kinase
MDDAKFRSLWAKVVEQDNAQEHSIRNTYKEEVTFSHDITQLPQQQTFSENATVSMEDNIEKVTFSAIETAAPKNVSKTQPDLDTKHDYKNYQEINRGGMGIIYRAEQTKLKREIAIKKTLPQVEKSKFLAESLVTAYLDHPNIIPIHEIDQNDEGDILLAMKLVKGISWKDLLYPRTVEHQEKAKEYNAQKHLEVLVSVCNAMKYAHSKGIVHCDLKPENIMIGDFGEVLVMDWGIAVDVRENPDERRTFYKNDITTPMGTPCYMSPELAEGRGKDISFATDVYLLGAILYEILHRKPPHAGESLWQVLLAARNSELHCESTTPAELQQIFRKAMAREISNRYQDADLFCQDLQNYLQHQESIFLTETAVKELLSSQKQQNKEQVYESLMTAIVRFSRALEIWENNSRAFSGMVQARLAYAQIALNNNDFGIVSSQLEKIEQLDRQKHLRKFGYVTKDKLSQLQFLQKKLQFEQKKQKNLLRMHRWLNTAFFIFFALAFLAAQNVKVQILPVILFAGYALVTRGNNAAFFVIGYPVFALLSICNFMMLLFLTQFEVDMWKVLVLIGAIVFYCIWKLRNTNNKNGVRLQTYFDFSGIHRDADDQIDFKNTVEMLIINLADDDTDKRINTRNKLQEIGYPAIEFLLEAAKNHENWLVRLNCLKTIAQIAPGDVALRNSLRELYDLEQDEDVKKQLQSML
>NZ_AP019860.1|WP_151970341.1|6471152_6471674_+|hypothetical-protein
MKKCLTILTMTVLSSFVFAGSSKGEVQRNIKRGGWDVVWGVTIDEKEYIKFGLSAYSGNPWVYFSNYLDRNIDHFARNLRGVGKRALKDLIIRSFKSRGAKMRIGRIEVKAGIATYRRWKRVVYDEPRTRKVKRWINKRWGWWTWTVQVYTARVTKRIPLPNHHQPYVAFRIR
>NZ_AP019860.1|WP_151970340.1|6467744_6470999_+|hypothetical-protein
MDIEETKEIWLKIISDEEMQNGSIKKTYKSYNSNKVLVDDIPNSSNSVDPLKEEPKENSVNQIPEERARISSAQTDINSSENDIPTDNTTERAVAFSTEDFSEIENRKESLILWKINSTFRFLGNYFRFLDKKFKIKSSYVLVTVTFLIIFLIYNSLQQGKITTAHNIASMRVNPENSCSTCHQGQGISNTERCIRCHQQETDIRGEESSSAALNIHGLSQNHWKKYGLNDKKVEEFRFSQTLSQAKKNLDNAVSPQIACSSCHKEHQGRNFNLSVVDNNSCQICHNQSSSDFWKGHPNFDNYPHKKGTHIYFNHTNHFEEYFEDRSRSSTAPHNCNACHELDKSEQAMLTKNFEEACNQCHQTNILKEDEDIAVIRFPGFLTEKFYLQSKQFEVRPKFTHWPSIDKEDTGEATDFMRLLLSKDKELSDDDISKYLDTFLYDHIADSPTNGKKNEIKAINAYIMMIQRLCDEITSENTLALKRRLEKILHVSIKSETIKNLFPNVAEFLQVIQSRVFPPINTQDSKRFNNFEFKDENSPTGWYFRNYTLHYRPSRHKDPVMKAWLDLMVRSYNTDKPDSEGEVEGNTHYVLNAVNRCLKCHTIDKVESKDAAWEINWESSKTKPKVQFTRFSHREHILAEMDCSSCHILKKQDPVGGNNKFFDENYDRKKLISFRSISKDLCSSCHNRNVANEKCTTCHNYHARSFKTDPYGSIRYMVDQYKNEMANTKSVVDQHENDVVQKSRKRKADIQVVQKNQATTSKSKIEKTQEKTTKVFLSKQETQQQIKRISAIKKRPVDIKKIVTAKKCGFCHTQEAQVWKKTPHYKTFAEMEKRPRAKNIFQKLGGKGSIKKSGRCDKCHYTQQGGTNKVVSGVSCELCHGAGKDWILVHNDKTVAKITRRQKSIDKGMNNPVDIYSIAQTCYDCHSVPDEELVNVGGHKAGSAFELVSWSQGTERHNFVTANNKENAVSSKERLRVMFITGLMLDLEYALRGLAKATKPGKYYETMLSKVNRTYKILKAANSKSGGIKEIQELLALFAKLNMKNRNHLETSANWITLKARQFVGNNDGSKLGFLDAFIPKHYK
>NZ_AP019860.1|WP_151970339.1|6465917_6467711_+|protein-kinase
MPEEKDVTFSHEKTLAKKEISQTFTNEKTIANEKVNRTFTNEKTIANIEISETFTSQNTVAPNFGQNNQNVDIANTAQMSYGNEDYEILDEIARGGMGVVFRGKQHSLQREVAIKKMMDNDKNKKSSFVFESLVTAFLDHPNIVPVYELKQSSQQIMLAMKLVGGVPWSSLLHPKTAEQRKMAASYDTQDHINILFSVMNAVDFAHSKKIVHCDLKPSNVMIGAFGEVLVMDWGIAVDIDDSRVNTPKAIHRLYVRHPMGTPSYMPIELARGQGRDIGPWTDVYLLGGILYEILTRKLPNTGENILQILAKLTEELQLKFTEDVPLEIQQICVRALQKNKNQRYQVIKEFKKDIENFLKHRESIDISNRAQKSLAISLDKIEHLKKNRKKVDGYELIYNDLSSTIASFQEALALWKGNSRAIEGEYAARLSYLKFALANQDIAIAKSQIIFLKRFADNSLDIKKIEKEIHKKDQEKKTMVHILSRIKITLYCWVIYHFTGFLKAIFISGNPFIENKDTYTVPVVVFLITILTILSLRFSIKQIFLYIAKIFSSALALSVLMACILYVGIYIYAFCLSLWNYSEYLRFMNEFQSFMSK
>NZ_AP019860.1|WP_151970338.1|6464960_6465482_+|hypothetical-protein
MKKCLTILTMTVLSSFVFAGSSKGEVQRNIKRGGWDVVWGVTIDEKEYIKFGLSAYSGNPWVYFSNYLDRNIDHFARNLRGVGKRALKDLIIRSFKSRGAKMRIGRIEVKAGIATYRRWKRVVYDEPRTRKVKRWINKRWGWWTWSVEFYTARVAKRISLPNHHQPYVAFRIR
>NZ_AP019860.1|WP_151970337.1|6462579_6464820_+|hypothetical-protein
MDIEETKNLWSKILTDEQMESGNVRKTYKGNSPSKSQSNVKHSGKRRETILHKTAELDEQKNLARVDAEETTVQQGPPTIKEKIQDKKNFDNANNYYKNDLPDYGAVKQAVSSLSTKDILETGHYQNMFMLRIILFVRSIFSHIEKFMAKIKMSYVAIAVLVPAIIIAIANSAQLGELTSAHAAIHTSKQNCHMCHTQDKNPRNDALQCTVCHQQSSDEIKNVTALNAHGLPEEYWEKHNPDFWKTQQNSFFNFSIKKPFAQKLDEIDIQKNEKLPPLACSACHQEHQGRNSILTKLSNRKCQTCHKKKFANFSADHAEFNQYPYKRRTNIMFDHVSHFSDYYRYKKKEGISVSQNCQTCHKFGQGEQMALNSFEETCAQCHQKDILKEDEDLNIIRFPGFLIEDFYAQSKAFKMRPKFRKWPSLDEEDSGEATDLMRLLLSKDKELEEEDISEYVETFLVDMIAESPSDEDENEIRAINAYVLMIKRLCDEITNEDTSALKERLQKVLSVSINNKTLDNLFPNVSNILQVVEERILPPINSKRKRHFNAFEFEEKELPTGWYFSNYTLQYRPMKHKDSFMKTWLDLMAKTYNTDAPDYYDEVQGNTSYIMSAMNRCLKCHSVEKSSQKDSVLKINWKPGKRGEEVQFTRFSHQPHVLAQMDCSSCHTLKKYPDFNKAAYNKSFSSHNSKKFVSDFKFISKDLCSKCHNRNLVGENCTSCHNYHAASFSKQFHDSSNFKTETSNKK
>NZ_AP019860.1|WP_151970336.1|6460786_6462565_+|protein-kinase
MQEDKNVTFSHDKTLANKEANETFTHEKTLANKEANETFTHEKTLANIETSETFTCEKTVDLKKIEQTFSEEKTDVGENNQSVDITETIRANHENDDYEILDEIARGGMGIVFRGKQHSLQREVAIKKMMDNDKNKRNSFVFESLVTAFLDHPNIVPVYELRQSSQQVMLAMKLVGGVPWSSLLHPKTAEDRKLAANYDIQDHINILFSVMNAVDFAHSKKIVHCDLKPSNVMIGTFGEVLVMDWGIAVDIDDDRENSPKAIHRLHIKHPMGTPSYMPIELARGQGRDIGPWTDVYLLGGILYEILTRKVPNSGESILQILAKLTEELQLKFAEDVPTEIQEICVRALQKNKDQRYQEIREFKKDIEDFLKHKASIDISNSAHESLMTSLRKIEELQKNRKKIDGYELIYNDLSSAIANFQQSLKSWAGNTEAIEGEYLARLSYLKYALSNQDIAIAKSQLPALRKFTTAENAIDIHNIERHIQEKDDEKKSIAYIWSRFVYSFSIYGILFCLNFLVELSSYSKNQRLINAFLFVCAITALLSLRFTGKQIFLLVGKLLSFIFMVVASVFLLLSLLGLIVILAERLSPIFFP
>NZ_AP019860.1|WP_151970335.1|6458169_6460293_+|hypothetical-protein
MNKKYFILLFLVISFLTAQEKKLYLDCNLETGKSLETGAVHRSLNSIYTTQNLGSTKTELIAKNRIILKPGFKSKRTKISVDKTNIERITIVGPDAFYENEQPQFDAYASFSETEPCLYKVTDKCLWKVTPSGHGKFENDPNVQMSNFFKTLSTDTRDLELNITANFAGTDITVQKSITVYREGIVDFTVKWDGKEIPEGYKSTKDLNLGAGGEYIYLCYKVGTPKDPNDRITGLFLVAGPEKVSVPPGYTFMGHDLNAASGGAYIYMAYKRGGYQPVQDIKVLIRHEDTPEGYEKIDLDLNWSVGGEYLYFAVKGGEEIAYRIVGEKSDYQEKSDWETFTSWVDEKGEHIGNFVKATFDIRRHLKVTNDYLGDRSKVLSKYIDNRFQTLDDGIRSELKNAGEYLDNRIRAVKNFDIENYDPQKEWENGMKFLRRRRQTLKKAIQVEFGRLEATLLKKLLNALMDERVSIPKDLQQDTDSQGKMLGGHIIYYVNGVLTTKTKAQISMRKLADSLQHPINVIYNQSQEDPKGYNTGNKFYALDFTETLSDLAWYNLNLFEKLTVSITDLDLRKAPDKIYVSNYCTRRVARLMYEKAKQSEPMTIISHSQGCAIVRNACFIMQILGYRPWVKKHLRWVAVGSPVNENLNHPRPPKDVRYYRLVDNDDPVVNFVGKSGPPSFDLDAHDFNETYLPRLKGIMKKLGMINTK
>NZ_AP019860.1|WP_151970334.1|6456485_6458141_+|hypothetical-protein
MKILLTLFLLPVFLLSDYYGPTKTVYKKIPTEMYLGGKMFGVEHKERVVTRKRIRLNPGFKISKFHAHVSQNIPTGISISGPSALYENRDGKYKVTAHFANTAPKDISNSCKWIVSHKKYGDINVGNFKAKAVPYDVDMDIIASLSIETVTFEISFPIKILKLGITSIQAGIDEDRADAIAKATANSHTWIEVRNANGFTSGSGGDTDYIDLGIKLEAISPEKRITGIAIVAGGEGTPIPHGYKAIVDLNKSCGDGTAYVYLCVKTGGNSPIEALIAAKDATTIPESGYTRINLSTNFGCHRQINDDLHHGDDIFIFVKGGNEILAIPYGNDEDYLHKRIDGYVNQKLAILKSEIEKAKEKAKVIQRELQKIETAINNAVDYSTNKWDKRAKIEKDGHKVAWGREITETDLAEILVAIGIDVSGGGGSATLTKLEEIGIESFEKITANTIDTFSLYLEETARQIANEIHDDVSNLIFDVMKKFFEALVAGEDPHDVIKEHVEGKIRSYGSIRIDIRAGVASYSGSNKLFGQTISKTFSWQPYIAILVYREK
>NZ_AP019860.1|WP_151970345.1|6478135_6480085_-|protein-kinase
MDNDTFRSLWSKILEQDSSHKSKEKTFSHDMTVPPQEQTFSGDGTVPPDSPSPTDTFSEDATVQPEDAVKKMTHSVTETTSPDLSTVQANFNVDQDYQNYEEINRGGMGIIYKAEQTKLQREVAIKKLIPGTEANKFLSESLVTAHLEHPNIVPVHELDRNKDGDILLAMKLVKGVSWKDLLYPQTPGHKEKAKKYDTQKHLDILINVCNAVSYAHSKGIVHCDLKPENIMIGDFGEVLVMDWGIAVNIDENHHKKHTLHKDNITTPMGTPCYMSPELAEGRGKNISYATDVYLLGGILYEILHRKPPHSGESLWLVLLAAKESKPLSLNEDVLPMLGQICHKAMAKESCDRYQSVEDFQIALNEYRQRHESILLATQANTLLDDTMSYVETNTKWEFWQKFKFVFIQFPGKTISPYWYFSSKPLRWLGCLIIAFVLLPTIPFLMPLMESIVSANTFLIFIGIITTLTLSAPFIFSAILISIFLSYISICLKIIQWFSSLWLPGLKKVHVFPESKLSPTEIYPNLVQAMTLYEQAIILWPENKNAQEDKIKLHTKLADLALDFQDTKLASVHLEKLKGSDSKDVQELHRKLYYSKIEEKCVKHMLWVAKMGGCIFFYSSTAFVAMLASNYLGITNFDILGWIKSIFFGQ
>NZ_AP019860.1|WP_151970346.1|6480420_6482316_+|protein-kinase
MSLSPKEISSLVDECLNNFLAAEQVKLALEKIDIHTGRIESSNTESIYLQNVIKYLCRHNRLEEWLNAVADDGFPFAERYLECITQMSSKDKQFGSYRIISRVGQGTIGNVYLAHDENGHRVTLKLITKEIVSKFSNKEELLQRFQRESNYAMLLNHPHIVRTVDSGNIDGNLYIASEYIVGKSLEDLLKDSSPLPVKQAVTIISDVLLGLEEISKNNLVHRNLKPSNILLSADGMAKIVDLGLLRSVSSDATLLTRTGNIMGTPAYMSPEQINAEKDIDIRTDLYSVGVIFYLCLCGDLPFQGSSALDIVEMHLKSPVPEPSVSINKKLLDFIRHLMEKDRSLRPASPKDALKILASIHEDPESTFAIGQLGTISRIPISVEKQAPDATYSGTGTIVTQNVLTPTSTASPLQSTKLVCEVEGVQHRLFVYAKDSLQIGRNSIEKEQQDICLRPLPAKGNEDGIRQISGKHFKIFVQNGSAYIQDLGSTVGTTLDGRQLIANEAVKLPALSTAVVANVIHLEISVIDNSPADTIGEIGSCRCEPSVFIRRKNNTPHHSYLLLVGKAALKWEDASFCAMEKGSNEILNVNNTLWLSGSVCGDGKAEPIGEGYSFSNQNSRFSFGVIRAEDQK
>NZ_AP019860.1|WP_151970347.1|6482465_6484010_+|caspase-family-protein
MTEQRLSPKQIHQLVQDLSDNFVEKDEVKNALMGIDINEGAISDSPNAKMYYTNVIKYLVGRQKVAEFLAQLSEHAFVTPWWDTLGVPPVAPKPKPVKKTPQKPAPDTKSETVNSISQATEENTSYLSRFSGRARAFIAVGSILLVGYMSYLLYPSTAGVGIPQKTILSHLRGQTLFSQPTAEKMSNEDWKKVLTEKGISGIEKFKVVNLTKKEKLLICTLSDKSKIAFHAVQRKNGHFHVYRKVPGEHRALLIAINNYKYWNKLKTPQKDVAELKKVLEEKYNFTQIDVLTDSDPQKYTVTQKAIIKSLEKLKNTVNIDDSVLIYYAGHGAYEKNGDNSYWVPQDVTQDASYRVECVQDIIIRDLLSEIAQNCKHLLLLSDSCYSGQLIRATRAGGGGIARQVLGKESEAQLRIDQYVVENDRKKSCQILTSGNVQQVSDNYNNSGHSPFAFFLLKRLRANKLRHYDASQLALELRKDVIQASKQSPQFGRLKGIAENDGEFFFELDISLLSK
>NZ_AP019860.1|WP_173013514.1|6484135_6486094_+|protein-kinase
MDNDTFRSLWSKILEQDSLHKGSTKNNYKSEEMTFSHDITASPQQQTFSGDGTLSPNSPSSATPDTYDNTFSGDSTVSSQDKDSPRETFSENATLNSEDIEKKVTFSATETTAGKNESQVQVEFNATQDYQNYQEINRGGMGIIYKAEQTKLKREIAIKKTLPDADRGKFLAESLVTAYLEHPNIVPVHEIDHDQRNEVLLAMKLVRGTSWKDLLYPKTPEHKDKAKEYDLVKHLQILINVCNAIEYSHSKGIVHCDLKPDNIMIGDFGEVLVMDWGIAVDVRENPDQKRTVHKNEITTPLGTPCYMSPELAEGRGKDISYATDVYLLGGILCEILRRKPPHTGKSLWLVLLNAKKSRPVSFFSASIPAELQQVCHKAMSKEIQERYRSVFDFKNAIADFLNHQESIAISDKAQKLLVENQNWIKEWNNLDEIEKRVQTPLLYENFIKATFGFEQARELWDKNLTARRYELKSRLDHAKFALKNGDLQRVAFQMDFIKMSEDEVGRDYVVNELETIKEKWLLEKEQKRRVKKLKQSIKAILYLMFSFALLFQLPAELQYRNVVFTTIVIFLAIVPLITIIPKKSTDEVKRSIYLTKRAHLFVVILVYPIVIFTFINLSLEHKMGIFPFLLGVVYIVWIYRFFLPKKNKLTTN
>NZ_AP019860.1|WP_151966752.1|6486583_6487834_-|hypothetical-protein
METGIPLIDRVQEIYPWYKSEEYKKLEERYGTRVKETLNELILYPIFQFDSINDISQTLQKNKNKYYDLLKDKDVDWWQLIKEISFGLLVTFLKKYRSKKEKSSKSRWKIRLILDSTIIKRWGRKMAYTFNVYNPTDRCYMHAQKLLFFAVCVGKDKFIFPLAPTFITSKQHPNHVSPKVQIKQMLLELNNYVHANGLTLDGVRMVTDSEYSIIEVMKLAKQLGLEFYGALKSSWVVNIDSVDTHVLELKNGCIPKPPKHSHSIGLYYRLNASHNILGDIALLIKPYFCPFTRRLKYSVFLSSNPNVNSNVIHQEHSVRWKIENMFRDFKHVLAIASYHGTYHVAQNASFAISSLRFIFARLSLKVAALSPSLRWNIKNTKFTLTKLSRYIRDHYFLDSKSFKLKRLQYSPLSSVR
>NZ_AP019860.1|WP_151970349.1|6488046_6489000_+|hypothetical-protein
MQEKIKLESIEKMQLQPSLQNICVICTKEISLQEEIAKDLCLECQKKQVWKHHLAKYLKNLALYFLAGCIFVIVFWLGVVYRFPDFIGIIALFLFVGCVYLFFEEFRTGFADLKKDAYLTEYFPSSRGLKVVYKEYLGFHFDSDYDFGLRLHFQNEVTKNWVNERLKLLKCPTCLKSDFTVDVRTNVHSYTDIPESERYETEYAIMCSHKCGAALVLDDISDLDQHIKNKDVSLVKTNEQWEEELRSQYQNLGKYQKFMAEGKKIGEFRINSTAMYKATIFYLRAWKNNPQDKSAEAAIQQCFNRHQKYQSVRDEEG
>NZ_AP019860.1|WP_151970350.1|6489004_6490981_+|caspase-family-protein
MNSIRLLICIAFLQFSVCQGQALFKGPKPGKISNYTWKKILKENGVHGVQRLVSRKMGREWHLICTFEDGTKQAFRAVIRKDQDKNQRYYIYRKMPGKYRALLIGISDYKYWRALKTPRKDVTALRRMLSKRYMFEKNEIRVLDKNVTREAIFDALGELEKNVQPQDSVLIFYAGHGAYDKQTADSFWVPQNANPEKNYRVQCIQDVVVRDLIMDIAEKCKHVLLLSDSCYSGALASTRGDSGIVREKDYSIQQADYYVQRHSREKSCQVLTSGSVEKVLDEYKDKGHSPFAYFLLCRLHNNKLQYYDASQLAIHLRKDVANKTKSQQPRFGRLKFEDEKHTDGEFFFQLKTSEIENTQVIFDINNLEKSQINRDYDALSRKISKNGISETHKMKYLAEFLQKYRHKSQTRGTQGNIIKEVQDKLNSYQEMHTVIDPSPRQKKPIPKNLHMSSSTKKLKSVYKKIFTGRDLLKKKYVKITPRFYRLFYQSVKLVDLAPSFSGKNYILIDVPLVKKKQLKKVKTTVITITANVTRTSEDFDPYFCIGDGKYAVGAYMYDSTSVEVIYGKVHKNYIVAQPLVAKNPRKAPKKGQTVDCQVKITIVNSMTVVEASLLGINMVESTPFPIDVEKKLNFMLIKDSNDDEYQINALSFKVEQEY
>NZ_AP019860.1|WP_151970351.1|6491043_6491223_+|hypothetical-protein
MDKAEFKSLWSKIAENDLDTKAKSYKTYTMVLIILGALFLMAIFLKRPASSLTNFKTPS
>NZ_AP019860.1|WP_151970352.1|6491304_6492357_+|hypothetical-protein
MKNITSITKYTALFACFMISNIYAGNAIYGDSYRWDKGVIPYRISERCFPRRSYQRQIVKQAIAQWNNKMPLQLVKACNQWDLVVFTATRNSCVTPVGRQSGQQKIHCDVSTHFTVGHVLHEIGHAAGLHHEHERVDRDRYITVHKQSCHLDDLPITHNAQPVGNYDYQSIMHAPKFMGSYMLHAPAAIGQRDRLSCGDVSTIIATNFDGKLVQAPGLPVALVQNGKRTAVNRYGSGCHSPSAVLQLSSKAYYNIPCAENILGHRGGFAEDHRVDNGFSTPFLGSQRQVFLQQQQMYRNVQHENRRLRHRLRQQKHQNRQRFAAQQRRQRFMQNTHRVFSGLHRRGGCGS
>NZ_AP019860.1|WP_151970353.1|6492525_6494223_-|hypothetical-protein
MKFTVLSIVFLLLIPVYANYTGPVKTVFRDIPPRKSIGKTWNSNADSFTKTIAKEEHFYLKARERITILPNTVIEEGAKFSASISSEIPTRVSLTGRTELYQGKSANYNVMAYFPESSKDVTNSCKWDVSHRDYAEITQNGKLEAKNVPHDIDIDIVARLKYQDFVIEINLQVRILVLAITSLKIGPYDLVKQGYTVITKQHSSVEQDLNEGAGGAYIYLFFKKEYVAPNKRIIGIAIIAADTERPKIEKGYAVNYVGDCNDDIGGGSAYVNVFFKRGYGYHPITDIAILRSPTPDQKHRDFQVIPLDINFGSGSVKKHADGTKTKKHGIPLFIAIKNGEETIHFAYGSDSDYGVTRYSDNIARFVDDAKKAFGDVEKAYNRAKTALKKIQKKIGSVADYETNKWRIKDEIRDGGWRVAWGRELTETDLLELIGAIGADFLGGGGVATATKLEELGLESVETLTSNVIDEFSTYFAEEKKKLVEEITGYSGKVIGIFFQALINGDNPKKAVAAFLKEKSREIGGIRVHFKAGVAEYSGSNKLFGKTISKTFSWQPYIAVRIVRGK

Crispr_ID: NZ_AP019860_32

• CRISPR_ID: NZ_AP019860_32
• CRISPR_location: 6585768-6586010
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP019860_32

Consensus_repeat	Method
AAATATGTTAGAGCATATGCAGCACAGGCACTGGGAGCTATAGGAGAAAAAGCT	PILER-CR

spacers of NZ_AP019860_32

>32.1|6585822|55|NZ_AP019860|PILER-CR
CAAAAAGCTGTCCCCAACCTCATTTTTCTTATCAAAAATGGGGATGAAAATACAA
>32.2|6585931|36|NZ_AP019860|PILER-CR
GTGCCAGCTCTCATTCTTGCTCTAGAAGACGAGAAT

CRISPR arrays and Neighbor proteins around NZ_AP019860_32

CRISPR arrays

The CRISPR arrays of NZ_AP019860_32

>merge|NZ_AP019860|32|6585768-6586010|PILER-CR
AAATATGTTAGAGCATATGCAGCACAGGCACTGGGAGCTATAAGAGAAAAAGCTCAAAAAGCTGTCCCCAACCTCATTTTTCTTATCAAAAATGGGGATGAAAATACAAAAGAATTTGCCGCACAGGCACTGGGGAAGATAGGAAAAAAAGCTGTGCCAGCTCTCATTCTTGCTCTAGAAGACGAGAATAAATATGTTAGAGCATATGCAGCACAGGCACTGGGAGCTATAGGGGAAAAAGCT

>NZ_AP019860|32|4|6585768-6586010|PILER-CR
AAATATGTTAGAGCATATGCAGCACAGGCACTGGGAGCTATAAGAGAAAAAGCT	CAAAAAGCTGTCCCCAACCTCATTTTTCTTATCAAAAATGGGGATGAAAATACAA
AAGAATTTGCCGCACAGGCACTGGGGAAGATAGGAAAAAAAGCTGTGCCAGCTC	TCATTCTTGCTCTAGAAGACGAGAATAAATATGTTA
GAGCATATGCAGCACAGGCACTGGGAGCTATAGGGGAAAAAGCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970396.1|6572119_6572209_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970408.1|6603696_6604467_-|caspase-family-protein	unknown	unknown	gnl|CDD|334197
NZ_AP019860.1|WP_173013519.1|6559814_6561464_+|hypothetical-protein	unknown	unknown	gnl|CDD|239819
NZ_AP019860.1|WP_151970401.1|6579990_6581994_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|379311
NZ_AP019860.1|WP_151970393.1|6561892_6564244_-|hypothetical-protein	unknown	unknown	gnl|CDD|236892
NZ_AP019860.1|WP_151970403.1|6589154_6589538_+|transposase	unknown	unknown	gnl|CDD|376616
NZ_AP019860.1|WP_173013521.1|6589583_6591626_-|recombinase-family-protein	unknown	unknown	gnl|CDD|214861
NZ_AP019860.1|WP_173013523.1|6605134_6606676_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970400.1|6577719_6579855_+|DUF1036-domain-containing-protein	unknown	unknown	gnl|CDD|368825
NZ_AP019860.1|WP_151970399.1|6575893_6577459_-|DUF4041-domain-containing-protein	unknown	unknown	gnl|CDD|214947
NZ_AP019860.1|WP_173013725.1|6594687_6595068_-|hypothetical-protein	unknown	unknown	gnl|CDD|238121
NZ_AP019860.1|WP_151970395.1|6571578_6571785_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970406.1|6592890_6594018_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013723.1|6591800_6592043_-|hypothetical-protein	unknown	unknown	gnl|CDD|379966
NZ_AP019860.1|WP_173013524.1|6606725_6608315_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970405.1|6592078_6592426_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970397.1|6572487_6574026_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970398.1|6574092_6575286_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013520.1|6564613_6571462_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_173013522.1|6591579_6591753_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_173013519.1|6559814_6561464_+|hypothetical-protein	gnl|CDD|239819	cd04327, ZnMc_MMP_like_3, Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.	5.12695e-29
NZ_AP019860.1|WP_151970408.1|6603696_6604467_-|caspase-family-protein	gnl|CDD|334197	pfam00656, Peptidase_C14, Caspase domain.	1.01327e-12
NZ_AP019860.1|WP_151970397.1|6572487_6574026_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.02677e-61
NZ_AP019860.1|WP_151970401.1|6579990_6581994_+|HEAT-repeat-domain-containing-protein	gnl|CDD|379311	pfam13646, HEAT_2, HEAT repeats. This family includes multiple HEAT repeats.	1.15803e-05
NZ_AP019860.1|WP_151970393.1|6561892_6564244_-|hypothetical-protein	gnl|CDD|236892	PRK11281, PRK11281, mechanosensitive channel MscK.	0.00133826
NZ_AP019860.1|WP_151970403.1|6589154_6589538_+|transposase	gnl|CDD|376616	pfam01797, Y1_Tnp, Transposase IS200 like. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	1.42008e-16
NZ_AP019860.1|WP_173013521.1|6589583_6591626_-|recombinase-family-protein	gnl|CDD|214861	smart00857, Resolvase, Resolvase, N terminal domain. The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.	1.81116e-25
NZ_AP019860.1|WP_173013523.1|6605134_6606676_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	5.36027e-50
NZ_AP019860.1|WP_151970400.1|6577719_6579855_+|DUF1036-domain-containing-protein	gnl|CDD|368825	pfam06282, DUF1036, Protein of unknown function (DUF1036). This family consists of several hypothetical bacterial proteins of unknown function.	1.09217e-08
NZ_AP019860.1|WP_151970399.1|6575893_6577459_-|DUF4041-domain-containing-protein	gnl|CDD|214947	smart00974, T5orf172, This entry represents the putative helicase A859L.	5.36035e-20
NZ_AP019860.1|WP_173013725.1|6594687_6595068_-|hypothetical-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	5.34299e-08
NZ_AP019860.1|WP_173013723.1|6591800_6592043_-|hypothetical-protein	gnl|CDD|379966	pfam17342, DUF5372, Family of unknown function (DUF5372). This family of unknown function is found in Bacteria.	2.11232e-07
NZ_AP019860.1|WP_173013524.1|6606725_6608315_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.62743e-32
NZ_AP019860.1|WP_173013520.1|6564613_6571462_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	4.98934e-31

Protein sequences

>NZ_AP019860.1|WP_151970401.1|6579990_6581994_+|HEAT-repeat-domain-containing-protein
MRQYFLIFSLLLSLTYCDDKQKTLDNAIANLRTRNYLLRVNSIKVIGGFGLKALPILYKQFFYEKALIPQYIEAYLVQQEIIRQFRRIGHADDRVVDLLKNIVKEDDDFLVKEAILALGELGKKAPRIIFFLIKVLDDRWGELAAQSLAKIGEKAIRPLGKVVRFSDTPEARCAAVNALGDIDSIKHPMLRYLMDASRHDPNELVRVAAVHALGKKKHTLATYILLRLIQDEAQAVGLAACASLAKHGKLAVSQIMDTFDKNPPEQLRIKLYGILTVIGKEAAPAIATLNSRLSSSSQKEFQAIIEALISIGYHKKSQQTIKRLIFVVYEQKNSQTLSLITSALQSYAPQSLPHVLPLLKSKRPQVVKVAVQVLESHFVDAIQLLQDQITKQKNPVFIANALKILAQDENSLPILIEHLQHENLLVCYTAKNMIIQHFSKSAFELLMKRIENLTNHIKALKSNQDKLQKSKVIVDTFVDLGEKAKIALMNLAVHESPSLRHMAVDAIAQSNSFFVEEKIAIFQAAIQVRRGTEQFVITNHLANLGEPAMEAILELLTSKELSVRECAIIALTKMRTPRAAWNLIWCLDNKQNTSFVIKALCAMHDVAMPILKKAISHEEPHVRFVCVVVLSKIESQESIGVLRKHSDVETHPMIRYVLEKALQQKGD
>NZ_AP019860.1|WP_151970400.1|6577719_6579855_+|DUF1036-domain-containing-protein
MRNLIALTLVMFFSTSLFANNWFEENINIFNRKNKLRKLGRNLDKFVAQRAIERAKFLGREVDKKLFQPILKTLEYTVPGHGYLKYLSDQAKDKRKYLPQEFIRIVQKHYRSIDLQKVTYAEDINTVHGDAITIGSEIYFPTRVDLTDGDDVFWMLHELEHVVQYKKIGVSTFLAKYVTQSISEALNQIVKGSFSVHDNMQIEIDADNKAKRIFADVMHKIEVVVPTVKKESINTFKIKNVKTGGYLFTRAILAARFYGGAGDIWQISYAEEQGKEYATMQNVRTKRYLYVERKDDGNHVISATQNISPKDIRCQFFIEKAQKDRDDGQYYIKSRKTKSYVYMNPDQIGYISRRIMLGDIPQKKEVAIWYIKEKEAHTYKLRNGLKKNIGHSGWTISINNMKISDKLEVVCGTDYADPRDTLWRFQKLSGTLCYKIQNVKSGGYLVKEPSCGKVKISVAPHIDKTREKNDYYYSYIWYVDPSPNGLQIVSVRSGQNFMDLNARIRKTNVNYHAYSALACESITSKKDFATAQKDIKFMNDQYEGGARIPTYHLHNKDKVVIEKSLNGTGGKPVVVDIKNRWYFWETQGVSMQKVGKSQKYIVYAKNATSFPIDVALAYKNKKGAWVRHGWWPLRPGEEKYLVTTRHRDLYVHAAGRGRIWGKTRPLSISYNNFKFVGKKKRGDHSAKFTKVLMDRPYYTYVFKHKTAKVKK
>NZ_AP019860.1|WP_151970399.1|6575893_6577459_-|DUF4041-domain-containing-protein
MEILLLAMAVAVVAMFVKYDQERKRAESCIESMNKLKRSVEPLYKYQKIVHVEAEIKQMHLQAQRAKTDYEIKCENLVHETNLKAKAIKDDAENYAMNLTLKVEEETKQLKRETKEKTDKQKQKAQEMLDNAIEESERIVKSAKDRAIEIAGDAIKAKENSDRYEKTAKAMKNIIDGYGDQYIIPNNTVLDELAEDFSHKEAGAELKKIRSQTKSMVTNGIAAKCDYVETHRKTTAINFVLDAFNGKVDTILTKTKHNNYGKLKQQITDAYNLVNHNGKAFRNARIEPDYLNNRMQELKWAVAVNELQLQEREEQRRIKEIMREEEKARKEYEKAMKEAEKEERMLKKAMEQAQKKFNQASEEQKQKYEMELNELLSKLSEAEQKNQRALSMAQQTKTGHVYIISNIGSFGEDVFKIGLTRRLDPLDRVKELGNASVPFLFDVHAMLYSEDSPALENEIHKKLASHQLNKINNRKEFFKVNLKDIREIVEEMGIEVHWTMVAEAKEYRESLALGDKNDDVL
>NZ_AP019860.1|WP_151970398.1|6574092_6575286_+|hypothetical-protein
MEYYELEQQRTETKWVWITLMINYIALVYADNLTRTEYGSLAIVVRIMVLTISLSLFMSLGRLGRRTGVGSCLGIFLAIIPFINTLYAFFLLKKSRKLLDRVGIKRSDYSLTAKKVFYDFDTFKKLNKYYFTDEMLISYDEQKFQKIGELLEEWNLYDFFYRKGLLSRLMHYSLRNEKYKKLEETIENISEEIKNAIDYDRPIEKKIYFIKSFYLQRKYLINNKLNKYYFDDKMLTLYDEKKLKKLKTLIKRWEVYESLIKKKILFYYALGIIHKRLQKLVEKTSEEIKTALGYQKIVYKDIDFIKSFCEAQRIYLQKTKYDFSNEMLNFYDENKLQLLQQIIDHKGPHDHKVINEICSKIKKNIGYSQKVDDELSFVESFYYTQKEFLSKEHRNET
>NZ_AP019860.1|WP_151970397.1|6572487_6574026_+|protein-kinase
MDDVKFKTLWEKLLNNSEDIRYTYKPSETFSDKNTIVPQDATDTFSSKDTISPENSKETFSDNKTITSSENPEKEKAYTKTKIEVPLDTKQDYTDLKEINRGGMGIIYQARQKKLKRDIAIKKMLSDKGKEKFLAESLVNAYLEHPNIVPVHEIDTNDEGEILLAMKFVQGISWKDLLYPKTKEQQDRSAEYNLEGHLGILLNVCNAIAYSHHKNIIHCDLKPENVMIGEFGEVLVMDWGIAVDLGSREDEVKETRTFKNTEINHPMGTPCYISPELAEGRGKDISYATDVYLLGGILYEIIYKRPPHQGNTIWKVLLSAREGNMPPFDESVPYELRSVCKRALQGNMGQRYQKVQEFQKAIQDYLAHRQSIIISDKAKKILTEGENLFEIQEKLKEINFSVLYNKLLQAIAGFDQSLELWQENVEAQQGRDQARIEFAKVAFLNNDFGLAKAQLEETTSSIEVTELFNRIEFARLQHENISKKWKFYFRLAIIIIIAFLLVIIRLSTTYKF
>NZ_AP019860.1|WP_151970396.1|6572119_6572209_+|hypothetical-protein
MTKSLRKMGFGANRKKVLRLRNELKIRAI
>NZ_AP019860.1|WP_151970395.1|6571578_6571785_-|hypothetical-protein
MFIQKDVELLSKSTEKYILDTVAAIYAWQGNAMLAYKYADIAEKETLKRVKLLLEGKTPKQVEQEMKK
>NZ_AP019860.1|WP_173013520.1|6564613_6571462_-|HEAT-repeat-domain-containing-protein
MGWKYLQYVVIFFILFCLAFAQSEDEKLNKQLELLVAQLQSSNIDHSLSALVELRKLGDKAKVIRPELLKILKKVNINNRSIIQCVVDIITQSSPQQVKSKKTPKTITTRSAASRISKNLGGLNILGTSSDFHQRLRYNKQYAVVIGINKYDNFTNLKGPNFDASEIARVLRDRYQFDHVNLLLDKPSPRQANFNGRATKVTKNIVEDAVQSLKKKVKPDDALFFFYAGHGVPGYLVVGDSEKKHSGRPIEKSMVSLKAIAKSLESCGARHTLMVLDCCFSGSLLEKEYRPDFSNLTDKAFVSPGGSNLTRVFNRRVFQVITAGAGDEAVADKLDEISTIYAKQFKDSRGHSPFTAVFLQAIQGLTGRDDGIILASQLGFYMMDTLVNDDRINASQAPRYGTLGGNGDFMFFPVDKVLNPKMVAPLYLNGVEFAAFRRSGCEALENFIAEKSEKDRISLIKSALPHVVKLITDEQKIPRMAAVKFIKNEAQKYASKIEVFSIVVPILAKTLTPKKRKVVFSLSNDDQYMMIECLGSLHSHIKDEGPIDILKRYYKQQESQWRDHTKDKEIPYLVKERMKELPVDVDINSKTPQVQGHYYHQRIQIYRWLHSTGKEKIELYESSKNKFLSLTENVSTRLQSFDLLKKELTNRDFIEYFATRDKTIRTTVLAFLAGQDRDLPILFQLLKEGGEDIKIDAAKDLEKIGKRAFFVIVDRLKLAKAKKLLSQKKYLWLPLINWQKESLFPLINHLTYQDKQFLIPLFAEVAFDKLYSLMLNGSKNKQIRSQAAFFIGKRKTIEPFIAKFFISLKKKNVFEKLTAIDSIISPEKKCSMLEVVVELLKSSDEIVRLSSVKILKEMGEKAHSAIPALIPLLQDSDSKVREHTSLALAKMGEKAIPFLIVLLKNAQQNARLSAFTALQEMGERAHPAVPALIPLLQDSDPKIRVNVSLILAKIGKNAHLAIPALISLLQDSNSKVRGNASLALVKIGKKAIPFLIEALKNLDGDSVATVLQETGEIAIPALIPLLQDSDPHVKKRAISVMSEMGEKAHEAVPTLIPLLQDADPKIRESVSRTLANIGKRAHAAIPALIPLLQDSDRYVKKEAIRALWRMGEKAHVAIPALIPLLQPGAFTADAAYVLGEIGEKASPAIPYLIPLLNYRANQLAVVKALGKIGGKAEKAIPYLIPLLKKNGRRNRTVEAALKNICKNPFLIPVSQDPSTKVMKYTFVGRSRKRIDTEDILILLSLLHNQDNEIRLSAAKFLIETRATELREKMGKESHMAVPALIPLLQDPQMKYPAIQILGKIRGKAAIVHLIPLLQSKDIYVRGCVVQALGEMGEIAQKTVPLIIPFLQDDDPRMRQTAATTLGKIGEKAHSAIPALISLLEDSNSKVKKAAIIALGNIGERAHSAVPFLKNLLQDRDYKVQGDVVEALGNIGERALSCIPSLMKLSNSHLLRWKAKQSLDKIRQKTQKFVPSLTFLLQNSNPEVRRYAISVINDIGEKAVPSLISILQEKNYNGRLSAVEALGKISKKADQVIPLLMPFLQDSAPIMRMTAAAALGEIGEKVHETIPSLISLLKDSDLEVKSAAVEALGKIGAKAEEAIPFLAVLLQDESSDLRRLATEALGKIGEKSERIVFCLIPLLEDENSKVRDVAIEALVNIGLTTQKSIFSLIPFLHDRDAQVKITAAVALSMAKEKVKNVVPHIIPLLEDQSLQVKVETANILGDFGQKSYLAIPQLILLLGSGVTGVEVQAISALGKIGEKSHLAIPYLMEFLEDGLNPEIRRVSAKALGRIGKKSQKAIPVLISRLKKEARGDGELYAYKEILEALVQLEEKSIPYLIPLLKDPSSSTRIRAAEALGKIGEKAEKAIPDLIPLLKDQNKYVRIYATEALGGIGKKVEKAIPDLIPLLKDEVPMVTINAMEALGKIGGKAEKAIPYIIPLLKDNVYENAPETLGKIGERAIPHLIPLLKDPSSNTRSRAAQALGKIGEKAEKAIPHLIPLLKDTSSSILSRALGKIDRPRSRAAQALGQIGEKAEKAIPHLIPLLKDKYSEVRESTAEALGQIGEKAIPHLIPLLENQHPEIRKGVTKALSKIGKKALHAIRKSNHVILNSYLWESYLHGYKNAFTQRDIELLSQSKDKTHLETVAITHAWKGNEKEALKYAKNCSKNAKIRINLLLKGISQNQVELVIKNNFKFLNDRLWENYVKEQSGGITKQDIIILEEAYETHQLDTLAAIYAWKGNIQKANKYADKAQGEAFKRVKLLLKGKPPKQVEEEMKKGQN
>NZ_AP019860.1|WP_151970393.1|6561892_6564244_-|hypothetical-protein
MNYLKTFFLILVFVSFGFAEDDKNVAINEMNTRISKLEGQLEKVQKQSDILNSQFLPLSKYRFLRVSVFGGDYKLTIDTRGKFAHVNCVQGKILEQDDRSFKIEKTSGWSHVDFIVEVKIFDKVISVYARNDQPREIILRDHLNQILNKNRDNKVRIGGTHRIYSIKTQTAENLLLEEQLENQQSKSNLLQKQIDILNSQFLPLSKYRFLRVSVFGGDYKLIIDSRGKFAHVNCVQGKILEQDDGRFKIQKTNGWTHVDFIVEVKIFDKVISVYAINDQPREIILRDHLNQILNKNRDNKARIAIQRIYSIKTQTDSLDVDGTTKSNGDSEIGGNLTVSDTYLPKDVLELSAKNIEMNNKGISTKGRDVYFHSDSADFAHGIGMYHDTKKFANVNVNGPVVYGYYGGALGSTEGGQKIALRWDSNGDVKVTGQLSAKKISGAEDLSIGKVNANIISLNGGGTIKRVFDNGNYSLEISSTNLYINNKGISTKGRDVYFHSSITDFNHGIGLYHAAYSDGNKNYPAKLFAGENVNGPVVYGYYGGALGSNTNKIQKIALHWDSAQNVSVKGNLTTNKTLNANHISTKSVNVTEKFDAKSLHIDKDGWIGMNTAPVKDFTLAVNGRIGIGVTKLADAATKLAVKGKITAEEVRIVKMDNWADFVFADDYKLIPIDQLEQSIKRNKHLPNIPSEREVKEQGIQLGEMQAKLLQKIEELTLYTIQQEKKITTLQQQKNTLENKVAKMKQNEQKINALQKQLVNMQQNEQKINALQKQLDLVLKIMRNK
>NZ_AP019860.1|WP_173013519.1|6559814_6561464_+|hypothetical-protein
MFKILIATLFFMSMIYAQDICTTLDSGEGFTEQSFEEKEGLSLVGAKNKLWPSNERVLHVRFVGIDNDDIEQQIEEIVEDNWEKCCGIDFRFNNDPKAQITVNITHGVGNNSQIGTDSKTENPSMNFSFYKKNKKGKLYLPKNFFTVVDGKKKIPKDSYEYGTILHEFGHAMGFKHEQQSPRFNIEWHEENVLAYYKKHSPDWTEEDVRHNVLNKLENFRIARNVVTYETEWLFGFIPRVTKKIDRRSIFIINYEATAFDQHSIMCYPLKLELTKNRTEWRLGTLDIDYKKDLDANNYTDSLRKALAKQKDIDVDFTAKITAYKSGYWILQTTLPVNSKLPTSAKVPKKSYRIIEVDGILEVYPALGGGRSLSVMDRYFSNKLYPFPTKTRTHNFVVREVKRAFDEILLRKPTADELSYYVNYMKQNDLLKLRDEVANLAEEKIKNLYFSLAGREPSQEEVKNDKKLLAMENFATLEASTSLEVNLRSREQFGNVAQLQVIGLYSVHAGGSFYVNNNETVEFRAGEEILLQEGFTAKAGSDFTARLYSK
>NZ_AP019860.1|WP_151970403.1|6589154_6589538_+|transposase
MRPIRISMINGLFHITTRCDNKNFYFREDEDFIEYLKVVEKARQKYGFKLHAYCITSNHVHLLISTPAEDNLSKLMQYINGQYSKNYNRRHKRTGHFWGERFYSTIIESENQLLNTIFYIELNTPPQ
>NZ_AP019860.1|WP_173013521.1|6589583_6591626_-|recombinase-family-protein
MEIKQTKITINHLQRKAVVYLRQSTERQVKYNRESTKLQYALANHLKKLGWSDVEIIDDDLGTSAGVGSNRAGFDKLIAMVARGEVGIIASREISRFSRTDKDWCQLLEICQIFDTLIGDNEGVYDLSVLGDQLVLGIKGTLSVVELKTIQMRMMAGKLEKAKRGEYFTILPVGYQLDVLRKVVKDPDLRIQEAIELVFKKFRELWSVRKLYLWFNEEGIKLPVHSCYGVGRKIVWQLPSYAFLSAVIKNAFYAGAYIYGWEETKTIVNDGKIKKIRTKNTSPENCKIFIPDHHQCYINWDTYKENNRILTGNKVTRKSDNQGSIRKGSALLVGVLTCGSCGRKMSIQYRSKTNYYYGCVGKHGLQKYCFCFSGSKIDEKFSQEILSAISPLGIKASLQAIEQKQDQHNDKRLVFEKQFQQLQYEANRLFEQFDAVDPKNRLAAVELEKRWNSKLEEVNQTRKMLQNIAEPKVLSKLERKKIFKLGEDFTQVWCNENVSLETKKQIIRTVVRQVFVYLGTDTEILRFVIHWQGGTHTEFFIDKPLPFGRTSKKCIEVVKGMVKQYSDFEIADKLNKLGLTTGKGNPWQRKNVRSLRYAHSIPVYQEPNVFTKNQAAKYCNVSTKTIDKLVSANVVKNYAQPGTQPWKIKQEDLGSQRVQRIIQRLRETRKVIINDQDCLD
>NZ_AP019860.1|WP_173013522.1|6591579_6591753_-|hypothetical-protein
MQQQYFNFEAEKEAVKISEKIELELVAIMVKAILEADGKEQKNGDKTNEDNYKSFTT
>NZ_AP019860.1|WP_173013723.1|6591800_6592043_-|hypothetical-protein
MVILYPFHPLHGQKLKVLKNSSEEIVTVIDPDGFKRKIPIWMTKPDAQNYKLSSQKTISVSNLLLLSDLLEKEKKNTEEK
>NZ_AP019860.1|WP_151970405.1|6592078_6592426_+|hypothetical-protein
MTRNGVTKHPKEWKWSSYNQHTNGKGPVVIDFHDIYLSLGDTVKEKRKRYAAMMEERMLEKGLLSKQPHFPYGLILGTESFIKEIITKYTSHKFYKNRKSYFLDSQTACLRKPNT
>NZ_AP019860.1|WP_151970406.1|6592890_6594018_-|hypothetical-protein
MLKAIHYAKVELIPGIICDGYVLENETAVMSERGTAALLNLNQAALNRMITKGLPKSISPYIDIDLLTQVEAVEVEAKNSPYQGRKITVYNSYIIESMIRGYALALAAHTLKSNQRHIGDRCVTLLCSFVRTALEAAIKEACGFDSQIQKSHQNHYTTAIDLISEFGFRCSIQNDIATKKDITNFLSVPAGTLNSFLYKHNEIKPIKLDYATIQRAGGKARRMNGYHVKDVVKIVFGMDTAIGIELKQRMFGEISTLSKLHSKDEIQWRKIFSKVFSGYDLRFNHSIGSHRLRVDFFVPDLLLCMECNGYSHRNYNPEWEVQREKIITKKYALVRFHRETPLECIFNAILQAKPGKVVRLYSDQKVSLTKFLSHN
>NZ_AP019860.1|WP_173013725.1|6594687_6595068_-|hypothetical-protein
MTGHTNYIYAVSYSPDGKYFTSSTENHTRLWNATTGKQIHAQNRLEWKMLEFYRGEITEQDVLLALGGKEQMGQQTLAKFYYYAGLHYIANGEKQKARRYFTDCLAQNQPTQIESKLGIVELAAMK
>NZ_AP019860.1|WP_151970408.1|6603696_6604467_-|caspase-family-protein
MKYLSLFLLLFLFSINTTAQKLHMISIIDVEDESIGEGCEKDRKNMKKERDRIVKYSGLEKGEYYEGIKKNFTKDFIFDSIANLEASGSDTILFYYSGHGGAADKLTFAGSLDKLPRLVVGKDYPRLSYIVELLEKKDVFSIIVIADCCNNYSFQDPKEDEIFFSLSKENVRKNYHKLFYETEGTIIATGCEPGQFSYGPVTGGAFTNAFLASLKKRAYADDTSWREVMEMAISRVLKKYKKQHPQYVLDISKHCF
>NZ_AP019860.1|WP_173013523.1|6605134_6606676_+|protein-kinase
MDNLDEKLRKLKNLYNRKLIDETQYKEQQQILISSWTQPPKITQTVATQTIGVMDTVLDDEPTSDENATNVAQKDTFSPGALKKQEILANTPSQVLDYKKRPTDKKCMQILAPSKVEVSDTKSDKVKNDGTYVKLEIIQGSKLDPNTFYEHDTLMVGRGSSTNCRVLQDRYASRIHCVLEMNPPKCLIKDLGSRNGTFINGQKYGKGEGVFLKDGDVLKVGRTVLKVKIHTVDVVDENYNETLFEDDRPEYERLEKVSEGPWTIYKAQNVQTKEYARLKVMEIDNSFSKSRLKRFFEQIQFLHTLVHPNICLFYSGDCSGNELYLATEWVDAKSIWDEVRLVGTFSEQRAKKIILQLFKALEYAHQQKIVHRKIHPKNIYITPDDVVKIVDFGLGMHFDMAGLSGLSLYEEEEEDILFTPPEQIQEYRLVDPRSDLYSAGALFFYMLTGKPIFDVANSDLMFAILDERTKPCSVSEFVQVSHQVESIISRCLIRNMEQRFKNAQEVVHMLENL
>NZ_AP019860.1|WP_173013524.1|6606725_6608315_-|protein-kinase
MLDKNIFKSLEMLKRGVKLYKTMAHSPNTVEFFGWGNFDDTKLFLVMEYTDGQSLQALMTRNISIKSSMKIVFALIYALEYMHGHKILHLSLQPSKILIDKQSRKVQLLGFSSRKYTTNFASLIHNYMAPELIQNSEKISAQADIYSLGAILYHLLSGQTPYGEITRTSKMLDAKLKQDPLTLNNKANIFTEIVKKAMAPEPQKRYKNVSCMAHALQKAINTYIKITNINIDFNKFVYKAEIIPNKVHLAQHLDYNVQAVFKTLPKGYYKEVVRGSRARARDNFNSFKTNIESIRTTLVHPNIIHIFGWHTSEQKGWPTSEQKVYLVMEYFNAWSLEQLMAKLRVIPLKYSIQIAVCIASALSCMHRHKIHSAHLAPSNIFIEKQTGIVKVKVRMEQESFCRYAISMDEIRSTRDYKVMLYKAPECITGQNKKSKQADIYSLGAILYHTVANKAPYDEPCKHKYIEDIDVVIKNKVMSQDPIPIQQLRKNIPDALAKTIHKALSRDPAKRHQSSDEFAKELQKVLDVIT

Crispr_ID: NZ_AP019860_33

• CRISPR_ID: NZ_AP019860_33
• CRISPR_location: 6804397-6804475
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_33

Consensus_repeat	Method
AGACTTTAGCAATTCCCGATGAACC	CRISPRCasFinder

spacers of NZ_AP019860_33

>33.1|6804422|29|NZ_AP019860|CRISPRCasFinder
CCAAGCAACAAATAACGCTCAATATCAAC

CRISPR arrays and Neighbor proteins around NZ_AP019860_33

CRISPR arrays

The CRISPR arrays of NZ_AP019860_33

>merge|NZ_AP019860|33|6804397-6804475|CRISPRCasFinder
AGACTTTAGCAATTCCCGATGAACCCCAAGCAACAAATAACGCTCAATATCAACAGACTTTGGCAATTCCCGATGAACC

>NZ_AP019860|33|27|6804397-6804475|CRISPRCasFinder
AGACTTTAGCAATTCCCGATGAACC	CCAAGCAACAAATAACGCTCAATATCAAC
AGACTTTGGCAATTCCCGATGAACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_152022051.1|6811182_6812577_-|NADP-dependent-phosphogluconate-dehydrogenase	unknown	unknown	gnl|CDD|236453
NZ_AP019860.1|WP_151970551.1|6817205_6818159_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970552.1|6818344_6819688_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970546.1|6805069_6807232_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970550.1|6814688_6817004_+|acyl-CoA-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|173839
NZ_AP019860.1|WP_151970542.1|6796992_6797892_+|oxygen-dependent-coproporphyrinogen-oxidase	unknown	unknown	gnl|CDD|376494
NZ_AP019860.1|WP_151970536.1|6788454_6788988_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236608
NZ_AP019860.1|WP_151970548.1|6810389_6811133_+|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293786
NZ_AP019860.1|WP_151970540.1|6793634_6795293_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970543.1|6798103_6799900_-|elongation-factor-4	unknown	unknown	gnl|CDD|235462
NZ_AP019860.1|WP_152022052.1|6812596_6813205_-|protein-L-isoaspartate(D-aspartate)-O-methyltransferase	unknown	unknown	gnl|CDD|225316
NZ_AP019860.1|WP_173013541.1|6792535_6792679_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970541.1|6795452_6796991_+|sodium/solute-symporter	unknown	unknown	gnl|CDD|271386
NZ_AP019860.1|WP_151970539.1|6792693_6793617_-|hypothetical-protein	unknown	unknown	gnl|CDD|235810
NZ_AP019860.1|WP_151970553.1|6819948_6821988_-|hypothetical-protein	unknown	unknown	gnl|CDD|224117
NZ_AP019860.1|WP_151970544.1|6799970_6802511_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970538.1|6791851_6792535_-|D-alanyl-D-alanine-carboxypeptidase-family-protein	unknown	unknown	gnl|CDD|350622
NZ_AP019860.1|WP_151970549.1|6813356_6814661_+|hypothetical-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_151970537.1|6789213_6791874_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970547.1|6807234_6810387_+|protein-kinase	unknown	unknown	gnl|CDD|270916

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970553.1|6819948_6821988_-|hypothetical-protein	gnl|CDD|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	2.77234e-10
NZ_AP019860.1|WP_152022051.1|6811182_6812577_-|NADP-dependent-phosphogluconate-dehydrogenase	gnl|CDD|236453	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase.	0
NZ_AP019860.1|WP_151970546.1|6805069_6807232_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.0823e-116
NZ_AP019860.1|WP_151970550.1|6814688_6817004_+|acyl-CoA-dehydrogenase-family-protein	gnl|CDD|173839	cd01150, AXO, Peroxisomal acyl-CoA oxidase. Peroxisomal acyl-CoA oxidases (AXO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. AXO is generally a homodimer, but it has been reported to form a different type of oligomer in yeast. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase acts on straight-chain fatty acids and prostanoids; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase has the greatest activity for 2-methyl branched side chains of bile precursors. Pristanoyl-CoA oxidase, acts on 2-methyl branched fatty acids. AXO has an additional domain, C-terminal to the region with similarity to acyl-CoA dehydrogenases, which is included in this alignment.	0
NZ_AP019860.1|WP_151970551.1|6817205_6818159_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.35533e-90
NZ_AP019860.1|WP_151970536.1|6788454_6788988_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236608	PRK09652, PRK09652, RNA polymerase sigma factor RpoE; Provisional.	5.34712e-37
NZ_AP019860.1|WP_152022052.1|6812596_6813205_-|protein-L-isoaspartate(D-aspartate)-O-methyltransferase	gnl|CDD|225316	COG2518, Pcm, Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones].	3.47936e-83
NZ_AP019860.1|WP_151970542.1|6796992_6797892_+|oxygen-dependent-coproporphyrinogen-oxidase	gnl|CDD|376494	pfam01218, Coprogen_oxidas, Coproporphyrinogen III oxidase.	9.43447e-140
NZ_AP019860.1|WP_151970541.1|6795452_6796991_+|sodium/solute-symporter	gnl|CDD|271386	cd11495, SLC5sbd_NIS-like_u3, uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain. Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.	5.29635e-154
NZ_AP019860.1|WP_151970548.1|6810389_6811133_+|ankyrin-repeat-domain-containing-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.17196e-13
NZ_AP019860.1|WP_151970544.1|6799970_6802511_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.90093e-91
NZ_AP019860.1|WP_151970539.1|6792693_6793617_-|hypothetical-protein	gnl|CDD|235810	PRK06473, PRK06473, NADH-quinone oxidoreductase subunit M.	0.00135386
NZ_AP019860.1|WP_151970538.1|6791851_6792535_-|D-alanyl-D-alanine-carboxypeptidase-family-protein	gnl|CDD|350622	cd14847, DD-carboxypeptidase_like, Uncharacterized proteins of the MEROPS peptidase family M15, subfamily B. This family of uncharacterized proteins similar to D-Ala-D-Ala carboxypeptidase pdcA (Myxococcus-type) are zinc-binding enzymes that belong to the peptidase M15 subfamily B. The enzyme D-Ala-D-Ala carbozypeptidase catalyzes carboxypeptidation reactions involved in bacterial cell wall metabolism.	4.92541e-84
NZ_AP019860.1|WP_151970549.1|6813356_6814661_+|hypothetical-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	2.80819e-39
NZ_AP019860.1|WP_151970543.1|6798103_6799900_-|elongation-factor-4	gnl|CDD|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_AP019860.1|WP_151970547.1|6807234_6810387_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.62696e-102

Protein sequences

>NZ_AP019860.1|WP_151970544.1|6799970_6802511_-|protein-kinase
MIIKIVLISVILLVVIYLYLMDIKSRSREEKAVPATDVTPKKSRNIPADIKVEILDVELPEIVEQAQRTCEISFTIKNSSEEEIEVESADLQFKSADEDVSHEYIVLPDNENESSITANSSITIKLNVDIGYKASTGKIDVTPEVFINKKDQTYNVGNSPEKQWLIEPRGRTFVISSEHDNEEVAGEAFSLALQTNVDGVADNSYNGVRRIYFTTSQGSSEVHTAEIPAYMDVEFSDGCARTHKSFRFYNITQKPVITASDTKPGGPQGSTSGILIRPAETGSFQLVLTSPQTTGVPVQGENQLLALDAYNNLKIDYQSDTVVYTNAKNCKVQGLSGPNEDTVSGSSFVDGRADLTALGLTFDIPKLDEPNMIKFIVAGDEKSGESNEILILPSSPAQASAEEQRKTRTILKKMLNFRKKRIFVANCEDNVFNMLRESFANLYDLQQVQVSEDNLSILIEKKPNLLFLDAGNPELDGYKILKKLRLVADLESLPILFLGSPYESEDKILSVLKSGCGYVTKPLTIPDLKARAIELLEKSAITQGKLPVRGGRLQGSDHLDYQIIGKIGEGGMGHIYQANRLRDNEKVIVKYLPPSDYKNRKAVMRFMQEALTVINFDHDNLIRGYDLMMDRNKCFYVMEFVDGQTLEEMIRSEGKLAPLTALDITMQVSRALESLNQEHHLVHRDIKPANILLTKEGVVKLVDFGIAKVTDQHCSMTTRGIILGTPYYLSPEQILGKDVTIQSDIYSLGATFYHMLVGDVPFEGNDVLDIIHQRLSKDPRDPREICPEIPLAISRIVLKMMQRRPSKRYEDAEELTDELRKVLDCIKTGRLESLEQEIRQQQAQEE
>NZ_AP019860.1|WP_151970543.1|6798103_6799900_-|elongation-factor-4
MENIRNFSIIAHIDHGKSTLADRMLQLTKVVSDNNLREQTLDTLDIERERGITVKSQTAALPYTAKNGKEYLLNLVDTPGHVDFSYEVSRALASCEAAVLLVDASQGVEAQTVANLYLAMENDLEIVPVINKVDLPSADIDGVLEQIENELGLPAEEVILASGKTGIGIEDILEAIVERVPHPEGNEEEKVSALIFDATYDPYRGAVIHTRMFNGVLKPGDKIKFMFSGETYDIEEVGYFRIQREKRDSLKAGEVGYIIAGIKRVSDIKNGDTITLNSNPCEGPLSGFREVKPVVFSSFYPIASDDYEDLSQAMERLQLNDASLIYEKDTSSALGSGFRCGFLGLLHLEIIQQRLEREFNQSIIVTAPSVRYRFQMSDGSTVYIDNPVEYPDSTFIKQSEELYIRANIVLPAEYLGPIIKLCMERRGIQQNMNYIDKKRVELIFEIPLGEVMFDFYDQLKSMSRGYASFDYEILDYRDSDLVKVDILVSGERVDALSIIVHRSRSESRGRHMCERLKDTIPKQMFKVPIQAAISGKIIARETISAMRKDVLAKCYGGDVSRKRKLLEKQKKGKKRMKMVGNVEIPQEAFLAVLKTKED
>NZ_AP019860.1|WP_151970542.1|6796992_6797892_+|oxygen-dependent-coproporphyrinogen-oxidase
MHENTQKMADIVNNVAEDICSRLQKITGDDFLRDPWERKDHYGNPGGGGITRIFKQGKHIEGGAVNTSVITGHINPEFAKRLKNDDSYLEAAGVSLIIHPVNPHTPTVHMNFRYIRQGEKQWFGGGADLTPYLPNTEKFVFFHQFWKDKLDAFDENFYPQMKDECDKYFYLPHRKEMRGVGGIFYDYVDVTDQNWEMVQSLATGFIDSYLPIFESTFEKEYTQEDRNFQLYRRGRYVEFNLIYDRGTIFGLKTNGRIESILASLPPNVRYEYMYEPASGTPYAEMVQYYQPHDWVNFSE
>NZ_AP019860.1|WP_151970541.1|6795452_6796991_+|sodium/solute-symporter
MFILNITNLRTLDLVAIACYLLGIIAIALFFSKKNNSTEQYFLGGRAFPGWAIGLSMVGTSISSNSFLGIPAESYKNSWVNIAPNLFLPVVTVIAIILFIPFFRSSRRTSAFEYLNERYGVVPRLYGTFSFIILQLARIVIVLTLLCLPIQFLTGYPIEYVIIAVGIFVTLYTVIGGIETVIWTDVIQTIVLLCGGILCFGCIWYKMPGGLSQIMEIANDNNKFYLGDFDWDLGRKTFWVVMFTGLVHWLREYSSDQNVIQRYLAAKSTKEARKATALCACVSVPIWVFFALLGTALFTFYTQFPVAGLDEKLQRPENILPFFIINNIPAGVAGIIIAGLLAAAMSSLDSSINAISTVTVVDIVKPYTHKERTDAFYLKTAKVVIIITAVIMIGGAIFMSRYQKTMVDISWILNSVLGGCLVGLFLMGFFTTRVDGFSASIALGIAILSNIYFALNSAQLLPEALSLNIDNYWVGILVNVVFITAAYSIAVVKKSSPKNLDQLTVWTMNKGE
>NZ_AP019860.1|WP_151970540.1|6793634_6795293_-|hypothetical-protein
MSESLVDIENYSHLLFGVIAIQEGLINNLQLLEALEVQREDPEKKIGVIFKDLGYMTMRQVLQILKEQGKFREKEPTRWPYIPNTMLKGLVYFSDKPVLQNVTMKSLLEAQKLFRQYREHKRPKSLAGILIEDMGLTNLQELKKIQNNMVFHARACDTCLRLFSLYNYDVSIKVECPVCPGNALSLDVNTWKKRKEEEEIAQAKFANMLDGSDEDDEVDEAYKPRATMALANFYELLEKNTANQKKDDSASPQLGLGKTMSMPMMKKQGVQGGLGQTMSMPMMQKRAVAKDSKQELKELYENLEEKETKREQNKANKLSKEHKKLKIREGKDTVFVAKKRQGRSKSIQAIAAIAIVMVMVVGLLSMGGSKNTEKQKKLLFKELKEDAPVTAKKSKKTAKLPGDIAQILVSKVTSDIERGGIPSQDHLNRYLKMLFVEQTKYEKSGDFWNLLGRLYLYKIFLDRFDKDLQPRRIDKIKNAAEEAFRMAQKNYDREDHQPTFKLIVANWMPEKHFGIAKEKTLNYNSNRDAARDIRKISSQIRDILELRKIKSY
>NZ_AP019860.1|WP_151970539.1|6792693_6793617_-|hypothetical-protein
MTKIKNILFLLLFISFGFAEINLFRVKNIKLYTENYPWLDELHLQVDGAARKGLNNTLITISIYHETQRVRWYDVLVKNVDGRLVFGGKWGPINNGVEEIQAGVYTVKVEVSLEKQSRKMFQLLTTKLRGQKIKAFEKKFPIGSAARRKREKKQNQQYYLEKIKTIQNIYEEMITNRNSVFRHIIKAKEKKMTIKQWRSWFNNSFNTRLTQLKQSLEKREKQFFSLRYKTTHDNIKLYCKFLKEMTVNYTKSFYEYYRKKSRYRPPYTNRQFTTHLRYIRQLHVESQKDMQIDLESKLGFMPPRTPY
>NZ_AP019860.1|WP_173013541.1|6792535_6792679_-|hypothetical-protein
MVTVTITATVTITATVTITATVTITATVTIMATVTITDSDGIFCLSI
>NZ_AP019860.1|WP_151970538.1|6791851_6792535_-|D-alanyl-D-alanine-carboxypeptidase-family-protein
MNDVRELQLTGQVRTHITQIDEPRFAAHPKTVEAFLAMRDAAQKEGIILQPFSSFRNLKTQIRIWNKKFRGEKPLYNIHGQERDYHSLDKNEIIDAILGWSALPGASRHHWGSEIDVVDAAVMPQNYRVQLLPNEVQSDGIFARLHVWLDENMHKFDFFRPYRLHQGGMFPEPWHLSHAPISIPAQQELSIAMIENVIRNNHLEGKELLLRRLPQIFRDHINNVCLP
>NZ_AP019860.1|WP_151970537.1|6789213_6791874_+|hypothetical-protein
MHFSQKRGTAIVIVLIILSSLSFLSIFFVRIAMRSRLASENYTLRTLAQLTAYAGIDHCLANTFHELVSGNIIDAPTMKKQRKNITGVHKGIGGTTGYVIGKNRMGNYALDGNVYTTKMTSEMAKFNVNGYVAVRAKYQLHSNETLYRILHTLAKTCKCDDAKQIAQLIAHHHIKNNQRFYCHEHLRTFLQKHFANSPQLQRFVSLLSVSPKRQKCFAALAQGVYYEEWRCAVDVNNISRELLYALIFNIKATANFHDVQVQTNDRGALRSLREKMQQCTVDFSDDAVNVYEIVDYIQNRVAFTGPFTHFMEFAQFVESLPKQFFPTCPVNIRPSFWRQMWRDALKSNFTRDVVDNNCNPNSPMYVSVAKQNLCVKKDNQFFCGHTAELLFFHCGPFVVRAQAHINTHNQCVARARQMMEVVWGKTLVHSTQKDFQTMNAQQQETLSVGSCSSSLLRKYCGFVEPKPRKMPKGLFTLSSYPDDIHTQMSYFGGVYNDDGTVFTKKSKLSSRKLISSLREGVNHLHHDGLVSSQAYYRNRSDNDHYITHAITPQSATEDLRGCNTISSSHIANYNGSIELWIKLNETPGNVRFPGPHFMLMACTTKNRLRFVDDTQQHKFHEGTQMLLYIDSFGYLRFSRQHYTRTFTLDKRRKIVEYGVSSQHRDPRRGFTHRHIEVNVANLGWRAHEWHHIIVRWHDEKRIVTLEVDGYTPQEAFVEEKNAMAILNEVDPRDVLFINGYHRYQATNTGYFPFTRTVNLFGNATIDKFISYDDHLEAQYKSRYLNNSRYNNAFIVNGKYIRGPLYWNSYIKGEGDYTQQTTVEVFSNNVLHKNNMLIPKNTMMANRMEYSVRFHCGKKRNLSIECPALGMICQVVLFTYPKVNKHY
>NZ_AP019860.1|WP_151970536.1|6788454_6788988_-|sigma-70-family-RNA-polymerase-sigma-factor
MSDRQDEQRCILSCQNGDCKSFEFLFNKYRQKAYRAALFITKNPQDALDASQNAFIRAYRNIKNFDNQQNFYPWFYKILQNCCYTQLRRKSNSGEMQEVSDMRLNPAWLVQRNENQQNIVAAMNDLAISEREILQLKYFQELSYKEIAATLDIPMGTVMSRLYSARTRLRQLLDKEE
>NZ_AP019860.1|WP_151970546.1|6805069_6807232_+|protein-kinase
MSTTNEKHLISLAIKMGMITSQQLQQCLAIQKQQGNIPLMSVLNREGYLSEQQINDLWRQSTNQRVVDSQTNAGDNTNYPQASTPTKKSEYVPSFGRYEIICELGRGGMGRVYKVYDQQLRREIALKMLLLGTNDNDTDFQRFQREARATANLNHPNIVRVYDIGIEDSYPYFTMDLINGGSLKERMKNLSIRQAVDAMMKITDAIHHAHGQGIIHRDLKPANIMFDDNNEPVIMDFGLAKTSKASRKLSRTGTVMGTLHYMPPEQAGGRSRDVDARSDVYGLGAVFYEILTGKPPFTTTNYAQILNQIINVVPMPPTKIKPRIPKDLENICMKCLEKKKEKRYQTAAALKRDLQRFARGEKLEASSGMLRKTAMAWQKYQKILMFAGIFVMMVAAFLLGKSFDEPSSKTKPQEKQTTQTPPQKTPKETSSDAAENIPFAKEIWQAGWDTQNKRFDFSHEKWRNLSFETQKQYARQYQIWYASENNLSLTKKVRALNMIFVLVPPGVMYEPRKPKKQKREKKLIVIPRAFYISKHEITQEQWQQMGMRIVAPSPGRNIPVKEINVLEIEEFCKRMNNKHGRSGFFRPPHQKEWIYGCMAGSTYKYNIGDKLFPSQANIHMGKPVSIEKFAKFANAWGGCSFHGNVGEWMENWRYGGRWPDDPSHIFKAFHRSSFLGKKEVYNFGIGGNIMRIPFVGFRLAIGDRVFDVYPPRKKKKQNGK
>NZ_AP019860.1|WP_151970547.1|6807234_6810387_+|protein-kinase
MNNWYIAKKNDKEIYGPFSASQIRQYLEQKKLQLDDFLSYDKQNWQKVREVFPPPDLKFQDYEILGELGRGGMGVVYKARHKSLNRYCAIKVLHSEDENSQKQFIKEAKAMARLDHPNIARIYDTGIHPMYFFAMEFIEGETLTKWMEYKPSTTRLLQIFRQICFAVEYAHKNKIIHRDLKPDNIMVKDDNVKVMDFGIARQLDTENTFYQTGEIVGTPHYIAPELLNGFKSDERSDIYALGVILYNLCTGRTPFEEGNMVQLLYVISTVDPPRPSEFRPRINKDLEVICMHCLQRNREARYQKVSLLRKEIERVLNNRPILTRPPSTLKKCVQWCYHHPLTSGLLMIIFVVIPLMTMWFLYKERQNKNELAVAHQQLQETLIKTHLETAKANITTKNYSNALMNAKKAYEISQRLEKKYYQNQIFFTLHTILPNAPRLEKEYRFVNFEKAMVSPRKQFFAGIYINEKKQPMFVCGKFDVQKRRYEFSDTLFAQKCRTYFIDIDETLQRAYFLDETKLHFYDFAKNEVVRLFDVDHEIEKIVHVPDGKKMIVDEGNTINIYSLPQKTLHFDIENVDGSFCVSRDGKFIAACVRNGIRIFDIDKKEESHLIVYMGHRFSDVAFGQQNRYLIAGNEFGKIFVCDLKRKKDFIFSQHKNKVTNIKFNNDLRIFASAGQDKNVMIWDASAKLISITKLPGVPFHLLFDRKDKLWVHSQSANGTLVQQWNISPYLHKKLMLNEKRKKLLFGVQKSHNVEMEKIFTRPLSISPKGNVVIQPFLIGSLVWDQDDRFRFVSAIRTISDLRFLRFSHDEEIVAKARNREVVFLNVGNFEITGSISFANNIKSIEFSQNRNTLFITDHREIFVYDYEKQSQVRYSIGNYGSLSSATPDPKDEWLAVGTSDGVVVLCRGDFMNQRPQVAFEEDLRSGEIINIKWHVSGKYFVCISREGVVTIFRLVENQWQKWKNYDVPQDIKNLSFSPDTKASYLAVFTEQDIIIFDLQRDFSGKIYDGYYKGNSANLFPDWSKIAIPSLNGNILIFDFPTDVFAEVRRK
>NZ_AP019860.1|WP_151970548.1|6810389_6811133_+|ankyrin-repeat-domain-containing-protein
MDMFELIKNADLETLQNAISLGGNPQIRNNCGDTLLSVASGNGQHEVVEYLCELGIELHITNDFGFTALSSALWCSHMNVANYLVSKGAKINVECAAALGNIDALEKNLSKITSIEDMVGAYLLACRCGQLQVIQWFLDQKMPIDLHPPGSEWGGIGCPGLHHAVENGHIAAVKLLLENGADFTLVDDVYQSNALAWAAGAGNREITMLLREAGASVSQRNSHGLNAIDLAEEYGFSELAQQLKDSS
>NZ_AP019860.1|WP_152022051.1|6811182_6812577_-|NADP-dependent-phosphogluconate-dehydrogenase
MKADIGIIGLGVMGSSLAIHLSRKGWKVAVCDEFRPDLLEQHKKKFPRHMAANSLEEFVRLLKKPAKVLMMIKAGKPVDDYLEKLSVHLGFGDTIIDGGNSHFADSDRRHKLLTQKDIHFVGMGISGGEYGALHGASFMPGGSRQGWKEISPIFETITAKTDDNYPCCCWIGTDGAGHFVKMVHNGIEYGLMQILCEVYHILKCALALDHEDIYEVFQSWNRGPVRSYLLEISTAILSKKEGSTPILDLILDTAKHKGTGKWTAQAALDLGVAIPTISTAIHSRFLSAIRNERLFAAEQFALNFSDVELQDITNNIYHALCSSMMCTYAQGFALMHRASLEYGWQLKLHEIARIWRGGCIIRAEMLSMIDRAFFENNDLENVLIDPFFVNVLNRTHHHWRALVISALKVGVPIPAISSALNYFDSYRSAWLPANLLQAQRDYFGAHGYERKDRPGVFHSDWRKK
>NZ_AP019860.1|WP_152022052.1|6812596_6813205_-|protein-L-isoaspartate(D-aspartate)-O-methyltransferase
MVKEQIVRRGVKNPAVLQAMRKVPRHEFVPQESRALSYADHPLPIGKGQTISQPYIVAYMTEILELESTHRVLEIGSGCGYQTAVLAEIAAEVYTMEIVPFLAEMAQKNLQNYANVHFIEKDGFSGWPQYAPFDRIIITCAPPQVPQPLIQQLKIGGMMVVPEGTYIQSLKRIVRLTESDVREEHMLDVRFVPMVGQAEMQR
>NZ_AP019860.1|WP_151970549.1|6813356_6814661_+|hypothetical-protein
MKKGLVLENIESNTVYRGCTFYLKSYTRYDVQNTTFDNCSFRTHVKFSNLQNCQFSNCSFAQFLTIESDLEELPVGLCGCSSIKNLDLSYNSLKELPEEIGQLSALQRLNLKCNYLQKLPASIKEFSTLESLYLGCNRLSQIPDEIFSLSSLKNLDLQENRLCDLPNGVGQLTSLKYLDLRGNSLTKIPSEIGHLSDMDFLDLQLNNLEYLPKEIGYLSSLEVLLLDSNRLTSLPNEFANLGSLRELFLSANLFEEIPSEISSLVSLEFLDLHVNEISQLCDNFSNLQSLKKLCLGKNYFANFPVELTEISTLEILDFSDNHLREIPPEISKLSRLIELELSGNQLVELPVEVTEIASLQVLNLYNNQLTEIPREIGQLFLLTNLCLFDNQITQLPEEIKGLYNLQYLQLTGNPISEEHIQEIRSWLPNCTVEM
>NZ_AP019860.1|WP_151970550.1|6814688_6817004_+|acyl-CoA-dehydrogenase-family-protein
MHTSDVIIPSNERLLPILPMIYVAWSNNVLTPSEIEKIRAKMATMEWLQEDDSDILQQWLDPRTPPSPEQMQAWLIAIRENAKSQTDTSRRTLADLGAEIASIGGDNPKIRCTSKELCEALNEVEKALYVVGPEARKEILTQKITREKFTEKQQPQFNIDEMTDFLDGEYAELHQKIKNLLRDPMFKFPEKKLTTAEHREQVRKWCAEISKQGWGALFYPESYGGKSDLARFIVMMKNLAFHDLSLVVKVGVQFGLFGGSVFFLGTKYHHDKYLARIGDMECMGCFAMTEEGHGSNVRDLETTAHYDRKTQQFIINTPSDSARKEYIGNAACDGMVATVFAQLIIQDQPFGVHAFIVPIRDKDKNIMPGVRIEDCGEKMGLNGVDNGRIWFNDVRIPRENLLDRFAQVAENGKYTSSISSASQRFFTMLSTLVAGRISIGAASVTVAKTGLTIAVRYAEKRRQFGPAGEKEISILHYPTHQKRLIPLIANAYALDFSLQYLTRRYAEQTPEDTREIEVLAAGLKAYASWNATHTIQTCRECCGGQGYLAENRFADLKADSDIFTTFEGDNTVLMQLVAKGLLADLKQQFHEMNWWSMVKYIANQAAVAVIELNPITTRNTDEEHLRSASFHAEALRYREKSLLMSVAKRLKHRIENGMDSFEAFIECQNHLVSLANACMERVICERFQHEINTRATESNKPILEKLCALFSLNCIAKDRGWYLESGYVEVAKSKEILRQVSKICLELKPQAVHLVNAFAIPSQCVAAPIAK
>NZ_AP019860.1|WP_151970551.1|6817205_6818159_+|protein-kinase
MENNGKKKSDDSFPSLYLQPEKMSNHGEPDSKTSDIYFNIYPGDVLQDRYEVIEKLGEGGMGKVYKVNDLENDKLVALKITSFPSVNENNKIGMRFSREIEAMHQLVHPNITQVYTAGEYKQRLFYTMEWIDGCTLKEAMANCSQTVLLRIFMDVIRTIEYLHNQHIIHRDLKPENIMVTKTYQPKIMDFGLAKFTEKISRLTEKGAVFGTIDYMSPEQARGDISNIDHRSDIYSLGVILYQILTGKTPFQDDEMFVRIKNFFTASLIPPKEIIPEISEELSNTVCKAMAREQKDRYQCITHWMKDLQSIVEQNETQ
>NZ_AP019860.1|WP_151970552.1|6818344_6819688_+|hypothetical-protein
MRKQSKIIKFASVIVLSLALVSCAKNIPVTPITGVAAFTGRALIGVSDADMINTAYADGKLGNRSGLKDTMTFVPLPLNPENSNMQTISTPNSVISWPQIVDVSKDGAYAFVVETKGTPPQETKQFDDVYSGFPDGSLLTVVSLRNKLQVTDQKKIGLNPSAIMVSPNKNLLAITTDGDGRELCLVGFANGQVENIYPFHIPTYKNEHFRGGARSVAWHPSGNYIALNIGDREVAFYKIVYNEKGVPQKIEPFGNKITTGKYLTMGSFTPDGNFFLISDVAWGDSQLSYLFNPRGTLTSIAFGEKTKYHCIVSRKEVGYSPEGFAMSPDGKLVVTVNINRTYLPSIFPATVWPYRERSSLTLLTFDRETGRIKVIAEYGFDGLLPENATFDASGKNLAVAIYHNREEKPREGFIEFWNVTKKDNYALERTGYKIPCMRGIHDLVLVP
>NZ_AP019860.1|WP_151970553.1|6819948_6821988_-|hypothetical-protein
MPSKFLKLICSCAFAICIAVYSQASDRENQTWAYTKTFEGKVGPEWSSAKTSTTPSGRKFLGQFSKNGVTLSLNDLPPHSQVTISFELFIMSSWDGNSKEWGPDIWELSVKDGPTLLHTTFSNSGIQAFPQNYPGGKNIARSGASENNTLGYVFRYGGKRHPADSVYRLKYTFSHTEDSVMFQFSGIDLQGVHDESWGLANVAVHLDGKIDNKVQKRFEIVGPKAVKWEDEVVYETFEIKDGKQKPLHLNVKYQIQGAKSKDFKITPINYNKIRLQFPKAYAQFCEQNITLIAQVDFPVMGDDKSTANNASLDIVISNISDQCHLLQSEIKKIEAQIATLHREVRLCKEQLTTIKIPPRFSDEDAQKLQQQKESLKQQKEKLQTAVEKTAKAIQELRKQQQEANRLNMVLTRCMTQAERAFIALGNYKNSAKTRENKLEFLQTFLPRFHRGKTDSWSDGEVDNEFSIAYMKARKLAIARVGFGLVGIANLATMIIPHPGGRYSIVFEAFMFALGTEVDKKIDPLMNEVRNYNTLLKSEYYPMLKELQQLAEQVQKLKKKGPQAQLKKFENLLRQKVQKLQKMNLHVLSEAIKLVNIAKKRQKKMQKQLKTIEREWKNKKEQYEQFLVAQDKRNWEILDKKQSIFELKSKIQTSEEKLIRLNQRLQEFSTVYNKYCTEKK

Crispr_ID: NZ_AP019860_34

• CRISPR_ID: NZ_AP019860_34
• CRISPR_location: 7057194-7057294
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_34

Consensus_repeat	Method
CGATTTGATACGATGTCATTATTTATATTGTAGTTTAA	CRISPRCasFinder

spacers of NZ_AP019860_34

>34.1|7057232|25|NZ_AP019860|CRISPRCasFinder
GGGTGGGTTGAATGCCGCGTCTGAC

CRISPR arrays and Neighbor proteins around NZ_AP019860_34

CRISPR arrays

The CRISPR arrays of NZ_AP019860_34

>merge|NZ_AP019860|34|7057194-7057294|CRISPRCasFinder
CGATTTGATACGATGTCATTATTTATATTGTAGTTTAAGGGTGGGTTGAATGCCGCGTCTGACCGATGTGATACGATGTCATTATTTATATTGTAGTTTAA

>NZ_AP019860|34|28|7057194-7057294|CRISPRCasFinder
CGATTTGATACGATGTCATTATTTATATTGTAGTTTAA	GGGTGGGTTGAATGCCGCGTCTGAC
CGATGTGATACGATGTCATTATTTATATTGTAGTTTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970672.1|7060255_7061356_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970665.1|7050297_7051062_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970674.1|7062087_7062756_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|226607
NZ_AP019860.1|WP_151970673.1|7061591_7062035_-|hypothetical-protein	unknown	unknown	gnl|CDD|378270
NZ_AP019860.1|WP_151970667.1|7054692_7056009_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970661.1|7041182_7044155_+|protein-kinase	unknown	unknown	gnl|CDD|238121
NZ_AP019860.1|WP_151970671.1|7059427_7060180_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970664.1|7049499_7050288_-|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|366133
NZ_AP019860.1|WP_151970660.1|7038528_7041180_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970666.1|7051141_7054399_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151970668.1|7056018_7057050_-|DUF2330-domain-containing-protein	unknown	unknown	gnl|CDD|370813
NZ_AP019860.1|WP_151970669.1|7057442_7058072_-|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|131644
NZ_AP019860.1|WP_151970678.1|7069184_7070945_-|cytochrome-P450	unknown	unknown	gnl|CDD|365848
NZ_AP019860.1|WP_173013559.1|7062968_7066511_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970670.1|7058668_7059115_-|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	unknown	unknown	gnl|CDD|225543
NZ_AP019860.1|WP_151970677.1|7068359_7068812_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013558.1|7044251_7048364_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013557.1|7032800_7038434_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970676.1|7066525_7068247_+|hypothetical-protein	unknown	unknown	gnl|CDD|238121
NZ_AP019860.1|WP_151970663.1|7048293_7049430_+|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275381

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970674.1|7062087_7062756_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|226607	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only].	8.12416e-56
NZ_AP019860.1|WP_151970673.1|7061591_7062035_-|hypothetical-protein	gnl|CDD|378270	pfam09843, DUF2070, Predicted membrane protein (DUF2070). This is a family of Archaeal 7-TM proteins. There are 6 closely assembled TM-regions at the N-terminus followed by a long intracellular, from residues 220-590, highly conserved region, of unknown function, terminating with one more TM-region. The short 25 residue section between TMs 5 and 6 might lie on the outer surface of the membrane and be acting as a receptor (from TMHMM).	0.00944841
NZ_AP019860.1|WP_151970661.1|7041182_7044155_+|protein-kinase	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	3.88427e-50
NZ_AP019860.1|WP_151970664.1|7049499_7050288_-|FHA-domain-containing-protein	gnl|CDD|366133	pfam00498, FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.	3.97094e-18
NZ_AP019860.1|WP_151970660.1|7038528_7041180_+|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.65792e-77
NZ_AP019860.1|WP_151970666.1|7051141_7054399_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.69816e-07
NZ_AP019860.1|WP_151970668.1|7056018_7057050_-|DUF2330-domain-containing-protein	gnl|CDD|370813	pfam10092, DUF2330, Uncharacterized protein conserved in bacteria (DUF2330). Members of this family of hypothetical bacterial proteins have no known function.	7.21095e-22
NZ_AP019860.1|WP_151970669.1|7057442_7058072_-|PEP-CTERM-sorting-domain-containing-protein	gnl|CDD|131644	TIGR02595, conserved_hypothetical_protein, PEP-CTERM protein-sorting domain. This model describes a 25-residue domain that includes a near-invariant Pro-Glu-Pro (PEP) motif, a thirteen residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In nearly every case, this motif is found within nine residues, and usually within five residues, of the extreme C-terminus of the protein. Proteins with this motif typically have signal sequences at the N-terminus. This region appears many times per genome or not at all, and co-occurs in genomes with a proposed protein-sorting integral membrane protein we designate exosortase (see TIGR02602). PEP-CTERM proteins frequently are poorly conserved, Ser/Thr-rich proteins and may become extensively modified proteinaceous constituents of extracellular material in bacterial biofilms. [Cell envelope, Surface structures].	0.000238393
NZ_AP019860.1|WP_151970678.1|7069184_7070945_-|cytochrome-P450	gnl|CDD|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	1.88766e-80
NZ_AP019860.1|WP_173013559.1|7062968_7066511_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.63306e-91
NZ_AP019860.1|WP_151970670.1|7058668_7059115_-|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1	gnl|CDD|225543	COG2996, COG2996, Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only].	8.21239e-35
NZ_AP019860.1|WP_173013558.1|7044251_7048364_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.12627e-77
NZ_AP019860.1|WP_173013557.1|7032800_7038434_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.36377e-76
NZ_AP019860.1|WP_151970676.1|7066525_7068247_+|hypothetical-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	5.18351e-15
NZ_AP019860.1|WP_151970663.1|7048293_7049430_+|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275381	sd00034, LRR_AMN1, leucine-rich repeats, antagonist of mitotic exit network protein 1-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	5.64827e-27

Protein sequences

>NZ_AP019860.1|WP_151970668.1|7056018_7057050_-|DUF2330-domain-containing-protein
MNNYFKMLLFISIALSFTNSLHACATVSAKVPVEIADESAIIIWDEENKIQHFIRRASFQTEAEHFGFLVPTPTQPTLEKASDIAFSILGELTAATLIERQRSFGISWSRLSMVQVKSKSARSVRVLEKKRVSIYEVAVLEADSATALKNWLQQHEYQFPKNLKQWIQPYIDKGWKISAFKIAKDVDKKQIATSAVRMSFATERPFFPYREPQHANNEKTTKRLLRVYFLSNNYMQGTLGEEGKWPGKEVWAGPISTGHRNVILESTTLSMDTKPHDWQLTEFEDYSSYRPSGADVYFSNSSNQKQIRRPPQIVYVYNRGDILFNTIVYTVIIIFFLRYKRKR
>NZ_AP019860.1|WP_151970667.1|7054692_7056009_+|hypothetical-protein
MKIEHYESHKYMKLIDNGYRYVGDERKFFLLFYCFGALAVACFIFWPYEWYKIILTVVLGAISAVFFFASLPYGYIKDMELDHVKSKWSLSFMTPRHRLENQILNFKEIDCVYFMHYGNLSPSPGDLNMHIHIEMKTQNIPLACQKESGPRFQLEGIDSHSKMLDFAKRLAQILEMDKVVIERNDPLVCIIRLCRETKAKKIEVETTEISDLHTFYQSQMEPLPQLQKIVCKEWNPEESEIVGEVEYRRGESLVIKYQEPKESIWLMLLIAPVFAGIFTSTLAIPYFFFADTVLRHPKQIIPFFVVGYLVSIVGLILYILILKRQNYFAPQIHQFDLRQKTWTISDKDQQTNFDLNDANNVILSIRHQTVRTGARRRSGYKVYHVYFAVVRLSGLDEKELVVGQTQNYPRIADAYHHGLYFANVFCQACDKNLTLDAP
>NZ_AP019860.1|WP_151970666.1|7051141_7054399_-|HEAT-repeat-domain-containing-protein
MRMSVTYDILFKYGKMEEIMVIPKHKELCELIAGDIGLQRLQNRLYPSSAKIDRSSDSFTDYSQQGFLKQGKELLETIRKDWQVVVASETSHREIAQALRQLMDGKKQLHPDFGYRPVWYMTSGYQTCPWGCHSARGNDHGVIYHKKTDRAIMINTLHPHLIEKHFFFQGEEVYYRLDPQEIIRIFMLGKEAKKIASHLCRALQSSDKKIVHYALFWLQNIDITSIRKCITPYLKTLLSCKDRDLLKDVLQTIAKLGLRELAQDMAPLLSRANEDVQSVAKQTLEAMNFVTTPIFSDIQSAQIDTVVCHLASNLQNNNNVEESIRTLGLIGQKVPQDVFGLVLDFIDSYPTVAILSVLRIIKNSPHFISCLSIEHWHIVEALGHEKTIIDWQQSLIPYDRPESDNKKHDFLQQHNWSEVLKQIEQEDLFFHFVVAGLQFNHAASLQIVKNIKHNVFHYDDDDRKVDPMMLVQTLLENDDEEIQHFISRQIIKAYAPYPPVSTIRPQIDENVAQRLIKFVQRPPKLTDCKPRFFLWMIVTIDGGFTGTDSTWANIMFLLQRSPIEKEQIARHCLKYIHHHDYLVRIMCIFTIGELQYTQATKQLTALLDVDDRYVRQTVIKALENMGPLDDSTINKLIGFLDVKEEEYVVDATIDTLGNTHNEKVIDKLIEFLGLCECDMIWRIVYALQKLGALAEATDQLLLLLDSDDKDIQEEVVGAFGKIKLLPQEVELSLLKVVAKREIKASLSSRDNFIQVFRKKTLDEFWQTCNQQQKEQIIKNIGYYVNADICEIFLCDWQQYINGSDHLRFITFCCISKCITEENAHVFFPTLLEALKDKNLMPGAVRIITKILGILPQLMKKFAIDDTELSKLLVDAMEGSPSYGYHHDCREILIQINGNNAYGLDKFLDLLANYTDDAIALLQPLGDVGIDAIYQQARDGNDKKAKMAVYALYKINTPKCVTYLSDLVLHDNPEIKTRAAQFLCEYTQHKSQAVKTFIYLLQSQDNADIEIALTRLGFLSDNALQNLQNELIYILFAVYEVLHLKSAQQLFFRWAIHPYVKQIVLECRPQYTQHWQAAIFDTFCAP
>NZ_AP019860.1|WP_151970665.1|7050297_7051062_-|hypothetical-protein
MKKDTDWIKVVTAGLSTTNYNISERDEALLSILQRFQSPITNLFSRQFRKMGYYDKNYAQDMFAQFFSYILENRKKIFRSADPEKGKLRNLMFTIATRYFQKKVSMYVNATVFLDPKVMEAGFSHDTTEVDFEIDYVETLMNSTLVKLKEQDKSTDKIMFRMFQYKFFSKEKSKKTAFDVAIFFNEISEECSSIEKKKVEDRIYQRMKTAKALFETILLQEIRETLLLPDNIPIPQEEKNLFFQYAHWIEVNEI
>NZ_AP019860.1|WP_151970664.1|7049499_7050288_-|FHA-domain-containing-protein
MASLNIEITNSFTEVLPIDNRITIGRGNENDVVLLDGSISRRHAQVYKDEKNIFLEDLNSANGIWINGKKVVFRALENGDVIQIGNAKMTFSEEPLLEPTRIVDFREKANCNSTEIITANNILFQFFSSNKDIRQVCEIVEQKLETINATEQEKYQLGMAVNEAIGNAQRHGHKYNEEMVIEFHYLHFPGEEIVFIVRDQGKGFNSKNEVAHKTKLSTVEAAREIYEKGDWGGLGIKVMLKCVDQIEYNRLGNQITLTKYLK
>NZ_AP019860.1|WP_151970663.1|7048293_7049430_+|leucine-rich-repeat-domain-containing-protein
MKKTGTKIGEKIIGLENLDSTRYENCEIYLNEPITQLMDYEFHKCIFQDLKAHRIYDCIFEECSFSKFEVSNFFGDYQSRIYRVTFSKCDIAEFIIDAESAGFTMENCKTECAKLALIDEKQYHWDDQMIHLENLHNLTHLDLSQALIGDEGIAYLANLHNLIELDLCGTIVTNEGITLLANFPHLTKLSLECTKVEDEALRHIEKLHKLTHLDLSNTQVGNKGLAYLANLTHLTHLDLSNTQVGNEGLAHLTNLTHLTHLDLANTQLDDEGMIHLENFPHLVELDLYNTQVGDKGIAHLAKLYNLTTLCLWKTQTGDKAAAILANLCNLAELNINDTQISHEEIAKLRSSLPNTEIIFTAEKEDFFTMIKKWWKGLK
>NZ_AP019860.1|WP_173013558.1|7044251_7048364_+|protein-kinase
MNGKVKLLREMKKAWQDQDWEKAENYSDQLIKMNPKSSRGYYNRALIQMKRNKWDGVQKDLERVLALDPDYTGAQKLLKEAKRYLRSKEKVTNTSTQTHSTNTSSSTDAIHWQPGQIIDDRYETIKVLGKGAMGEVYLVHDLFWDIKLAVKMPLPKILSSPKVTERFTREAQIWVDIDKHPNVVTAYYVRKLDGLLRIFTEYVDGCDLKTHMEKSAIGTFTEGLDIAIQIARGMAHTHESNLVHRDLKSANVMISQSGEVKVTDLGLAKATALAEISVDESEVETSTPLTIVGKAMGTIAYMPPEQWRGSEIDFHADIYAFGCILYEIFCHRLPFIKDNEDSRSDFVAYKHMHNFVKAPTPESIKDPKLSWQTIPNELAQLMMSCLEKEPANRPQSFREIEKILLQIYYQITAKAYPHKIVDKLKQHAADLNNKALSYFDLGREEEAMELLEDAVIANSLCVSAVLNYRCMQYRKEGFPSEGFTYTLEWARSFSPEHTGPDLLENLFFRKPLRSFSVEFGLRVITPDGRFFISTDEVHTLKVYDVKSGESLYSLCGHSAKITAINVAPSGRFAISSCENSTLQIWDLDSGKSRCTLSCNEDKITSVAITSDGRLAISVSKDSVFRIWNVNAGKLMYTHSGDDRRNGVCESIRFAPGERLATSCFLDDERTPQIKVWNIHNGQLVHELPRDIRIVTFASDGRFVIHPDKNHNVLVWDVKSKQLVHTLSGHTEPIRNIKTSLDGLFVISGSEDKTLKVWNMENGRCVYTLSGHESGITSIAIAPDGGLAISCSSMWIKDRLGLLDRYDGTLRVWDIKSGQLVHQLSGHTSGINSVAFTPDGSFVISGSDDKTLRIWDIESGQCMCTLCGHEGGAEEVVVACDLAISEGKPSRNWLVWNLEIEKTKIEKSLLYEQITSSVQTMELEQEFRNLKEQIQQEWQSKNYLAAWKNVLELKKTVGYEQDKEVLNATYALSEALQYQRSTLYRKWFHGFLAKNIHCETIAGHLVFGSSSDHDLLVWDIRSKQLIHTFSDHKEDITHIAATPDGRFAISASKDKMIHIWDVNKKQQVYTSSGTGPVAFVGRRFAIFCQNKNLQVWDIKSKQLLGKFSDHTGEITSLAIMPSKCLVLSASYSSDRNDNSLSIWDIKSGKSVTNLSIHKECIRIDSIVGNFVISKKDGRFQVWDIPSEQLVLTFYMDYLAITPGGRFAIGARDSTLFIWETKSRKLLHELSGHLAKITSIAITPDARFVISGSHDKTIQIWNIVSGKQLGKLYGDTKPITGIKITSDGRFAISKDGKAWQFDWHWEKDTVDINDYQIKEKLTSGISGEIYLAHDLNRNTYNYQEQKETSDEKNRYENRRKDNRFRESGQYSI
>NZ_AP019860.1|WP_151970661.1|7041182_7044155_+|protein-kinase
MGSACALFVAMKIGFGQVVIEENGDFAISESQGLIKNVWNIELEMTKIEKCLLYEQIISSAQTVEIEKRAQGLKAQIQQQRQSKNYLAAWKNVQELKKTAGYEQDEELLSTIHTLSEDLQYQRSLLHRGWLHGFLTKNVHCETIAGHFVFGSNSNYDFLVWDIRSKQLIHTFSGHKKNITHIAATPDGSFAISASRDKTVHIWDINKKQRIHTFSGSGPVAISGEHFVIFCQNSNLQVWDIKNKQPLGKFSDHTGEITSLTVIPDECLVLSASYSSDRNDNSLSIWNIKSGKSVTTLSEHKDRIDIDSVVGDLAISRKDNLFQIWDIPSKQLVLTFSFPVEHLAITPCGRFAIGAGGNTLFIWETNSKKLVYELSAHLAQITSIAITPDGRFVISGNNSHDKNIQIWDIASGELLGKLYGDTKPITDIKITSDNRFAISRDGKTWQFDWHWEKDTVDIDSYQIKEKLSSGVTGEIYLAYDVNRNMQVVLKVLEKNIFKSLEMLERDVKIYKTMVHPPNTVEFLGWGNFDDTKVFLVMEYTDGQNLQTLMTRNASIKSSMKIIFELILALKYMHAHKILHLSLQPSKVLIDKQNREVKLLGFSSKKYITNPASLKCNYMAPELIQNSEEISVQADIYSLGAILYHLLSGQTPYGEIKETSKILDAKLKQTPLSLDNEANIFTKIVQKAMASKPQKRYENVGRMARALQKAINAYIGITNVDINFNHFVIKADIENKVCLAQHLGYNAQVVFKTLPYAHKWVTQAQRRFDRKIQHICKTLVHPNIIRVLGWHKIEQEAYLVMEYLNAWSLEQLMAKLGTIPLKYAIQTAIHLANALSCMHSHEIHPSHLAPSNIFIDKQTGVVKVKVQTEQENVPLSRRVCASNMNCLIHYIAPESLKNEIKSKQADIYSLGAILYYTVANQLPHYELNKNVIELMMEIINQDPVPVQQLRKNVPDALAKIIHKALSREPEKRHQSSDEFAKELQKVLDVIT
>NZ_AP019860.1|WP_151970660.1|7038528_7041180_+|tetratricopeptide-repeat-protein
MDEKVKLLHEMKKAWQNQDWEKAENYSDQLIKMNPKSSRGYYNRALIQMKRDKWDGVQKDLERVLALDPDYTGAQKLLQKAKHHLKSQEKVTNTSTQTHSANTSSSTDATHWQPGQIIDDRYETIKVLGKGAMGEVYLVHHLLWDIKLAVKMPLPKILSSPKATERFTREAQIWVDIDKHPNVVTAYYVRKLDGLLRIFTEYVDGCDLKTHMEKSAIGTFTEGLDIAIQIARGMAHTHESNLVHRDLKSANVMISQSGEVKVTDLGLAKATALAEISMEESEVEASAQLTIAGKAMGTIAYMPPEQWRGSDIDFHVDIYAFGCILYEIFCHRLPFIKDNEDARSDFVAYKHMHNFVKAPAPESIKDPRLSWQTIPNELAQLMRNCLEKEPANRPQSFREIEKILLQIYYQITAKAYPHKTVDKLKQHAADLNNKALSYFDLGREEEAMELLEEAVRANSLCVSAVLNYRCMQYRKQGFSSEGFVDTLKWARSFSPEHTGPDVLENLFFRKPLRSFSREANSPAIITPDRRFLIFTNEEHTLKVYDIGSGESLHDLCGHNAKVTHITVAPGGRFAISNSEDKTLQVWDLDGRKSICTLSGYEDEIICAAITSDGHLAISGHENGVLRIWNVSTGKLVHTLSDARCRSIRFGPDERFVISSFSYNDRSLVKVWDIHSGQLVLTSHSDLIRITPDGRLAMHPGENHTLLVWDLNSKQLVHTLSGHAEKICSIETSLDGRFVISGSEDKTLRIWNVENGQCIHTLSGHKSGIMRIVITPDGRLAISDSAWQDDYYTTLRVWDIISGQLVHELSGHTSYITSVAFTPDGRFVVSGSKDKTLRIWDIISGQLVHELFGHTSSITSVACTPDGRFVISSSEDKTLRIWGG
>NZ_AP019860.1|WP_173013557.1|7032800_7038434_+|protein-kinase
MDEKEKLLPKMNEAWQEKLLQEMKKAWQDQDWEKAENYSRQLIKMNPKSSKNYYNRALIQMKRDKWQGVQKDLERVLALDPEHTGAQDLLKETKRHLRSKEKVTHTSTQTHSSNTSSSTDATHWQPGQIIDDRYETIKVLGKGAMGEVYLVHHLLWDIKLAVKMPLPKILSSPKATERFTREAQIWVDIDKHPNVVTAYYVRKLDGLLRIFTEYVDGCDLKTYIEKSAIGTFTEGLDIAIQVVRGMAHTHESNLVHRDLKSANVMISQSGEVKVTDLGLAKATALAEISIEESEVEACAQLTIAGKAMGTIAYMPPEQWRGSEIDFHADIYAFGCILYEIFCHRLPFIKDNEDTRSDFVAYKHMHNFVKAPAPESIKDPKLSWQTIPNALAQLMMNCLEKEPANRPQSFREIEKILLQIYYQITAKSYPDKTVAKLKQHAADLNNKALSYFDLGRKEEAMELLEEAVTTNSLCVSAVLNYRCMQYRKEGLSSEGFTEILEWARHCSPEHTGPDVLESLFFRKPLRSFSQEASRPAAITPDGRFLILTDEEYTLKVYDIGSGESLHSLRGHSAKITYINVAPGGRFAISSSEDKTLQMWDLDSGKSICTLCGYEDEIVHAVITSDGCVAISVSKKDVLRIWDVKTGQLMHKLCGDDQMYTTFEFIRLESDERLAISCFRESDRPLIKVWDIHSGQLMFSSSGNLIKITPDGRLAIYPGQNHALLVWDLNRKQLVHTLSGHTEQILSIETSPDGLFVISGSKDKTLKVWNVENGQCVHTLSGHKSDVTSINIVPNGSLAISCSSAWLAPPNYKIVRPAFYDTTLRIWDIKSGQLVHELSGHTGHITSIAFTRDGRLMVSGSRDKTLRIWDLESGQCMCTLCGHEYGTEVVIAENGNFAISEEYYNTNETDETVSSISQGNWFVWNLEIETTKIEKCLLYEQIISSMETMKIEKRARDLKAKIQQQWQSKNYLVAWKNVQELKKTSGYEQDKEVLNATYAVSEVLQYQRNTIYRGWFYGFLAKNVHCETIAGHLVFGSNSDHDFLIWDIRSKQLIHRFSGHTTDITHIAATRDENFAISASKDKTVHIWDVNKKQRVHTFSGSGPVAIAGGRFAIFCQKNNLQVWDIKNKQPLGRFSDHTGEITSLAVTPDERLVLSTSYSRDRNDNSLSIWNIISGESVSTLSIHKECIRIDSIVGNFVISKKDGLFQVWDIPSEQLMLTFYMDYLAITPGGRFAIGARYSTLFIWETKSKKLLHELSGHLAKITSIAITPDARFVISGSDKTIQIWDIASGKQLSKLYGDTKPITSIKITSDSRFAISRDGKAWQFDWHWEKDKVDIDDYQIKEKLTNGATGEIYLAHDKNRNTQVVLKVLDKNIFKNLEMLERDVKIYKTMAYPPNTVGFLGWGNFDDAKVFIAMKYTEGPNLQKWIADNMSIANSMKIVFALIRALKYMHTHKILHLSLQPSKILIDKQSGEVTLLGFSTRKYTTNPASLIRNFMAPELIQNSENISLQADIYSLGAILYYLLSGQIPYGEIKETSKMLDVKLKQTLSLDNEANIFTEIVQKAMVPEPQKRYKNVSHMAHALQRAVNSYVTNGNIDFDEFAVNKFAKKADITKNKVILLQHLHYNAQVVFKVLPKTNDAKNVAKNPQAQELFERKIQHMRKTLVHPNIIRIFGWHRRAELACLVMEYFNAWSLEQLITKLGVIPLKYCIQISICIANTLNYMHSHKIYYSDDLTPSNILIGKQTGIVKVRVRMEQENFSAVNLNKQTIDFVFTLYWAPEFIEQNEKSKQADIYSLGAILYHTVANQAPYYEPNIHPIDLAMKKINQDPVPVQQLRKNVPDALAKIIHKALSRDPKKRYQSSYELAKELQKVLDVIT
>NZ_AP019860.1|WP_151970669.1|7057442_7058072_-|PEP-CTERM-sorting-domain-containing-protein
MKKYLFLFFFLLFSLSAEVINLIPSVSGVLQDVDLDGNFDIVFIVDLIDSQESAGLENRAVFEYDISSIVPGSIINSATVNINETSDPVFGNTNLFGYAGDGVIDVGDAVRTDAFIGNIANGTVDLQITDVTAFIQSLVDNNDPFASFVVDNENLDVIYQFQGTTAGLETELVIDFTAPAVPEPSTYILLLILSIFCFRSRFKNNKTNK
>NZ_AP019860.1|WP_151970670.1|7058668_7059115_-|type-I-B-CRISPR-associated-protein-Cas8b1/Cst1
MKKNLKETVGPGVFTPWQEVDVEICAFVDLGIKVVVNDEYTGLVYRNQIYDKYQKGQKLKAYIKCVREDGKIDVSLQPNQGTHVFLTAEKILKHLKAAGGKSRLHDKSSPEDIKKEFQVSKKVFKQAIGHLYKQFKIKITDKGIELIK
>NZ_AP019860.1|WP_151970671.1|7059427_7060180_+|hypothetical-protein
MVDENFKEQWSFSSMVVKAYESPFVSVLILLAGMAVATVVVPLYREEMDIVRAGEIVALALIRFLIYQQPKCFFYSLIFTGCMLPVASACSCPIFYYRWELEGMLEMAGIALLPGIIFIFFGYKGLKRLQTIPLTAKKDNEFLRIITEGAIILIAITFSMGVWNEATVVIITGASLVILVGVFSLLIPQLHLTAKMLGKILAFLGCSVVILCILLVATQGGRVDISEALVGIIPGAVVAGIGFLLVLGSD
>NZ_AP019860.1|WP_151970672.1|7060255_7061356_-|hypothetical-protein
MTKVYFVLFLSGMLFANSFIVEEIAANDSAQQEQVITGNGFIAAVVQTTDHDEVKCERAHQTDTHTANGILLSLDNGKTWQHNLLKEYRVNFLQLGDGGSVVAVTADNRYIQISLRDVKAPGEKVDFLHFPPTKSKKSPKWGPVLNDIMSHEVDFNNYDDLVTLAHETSHGIHSHIRNKMNKTGKTANGFYVLNNRAVVVVEPNMRKSKVAKYVPPSLRGSRYYTYVSGAPSWDDRPLYIWDEWNAYVNGSEAGIDLVDNDLWKYGWRDAVAGTLEFVVYSIAVAMAAKEHDPQYFNNYDQFREFLAWNVKRSMELYRKGAKIEHFKYEKQEKYYKDMQTSPDAEQFRQFCRELFGGTWTEQNLGF
>NZ_AP019860.1|WP_151970673.1|7061591_7062035_-|hypothetical-protein
MSTAKKWLQAVVYICAWFVLAFVITIIDSASWPKAFDNGVISSAFATSIVVMSFFLQGVVLHAFGWIVWGIVTILCIMFAHDILKLMKAREIKMLGSAAIGTVNGWVLVNHLGDKMFIVFYIAVIVVYAVLGYLWIVMTIPKSLNTH
>NZ_AP019860.1|WP_151970674.1|7062087_7062756_-|class-I-SAM-dependent-methyltransferase
MTKKYGQNNPKIIDYVESLVNDNDPHLAQAQQIAQHRQIPKIQVSPLDGRHLEVIVRSIGAKKCVEIGTLAGYSGICIARALPEDGVLYTFEYESTHAETAEEVFQAVGLSEKIYIFIGPALNNLSQINDKGPFDLVFIDADKESYPQYLQWAEQNLRIGGVVLADNVFAWDHIADQDIDNPNLRASVDGLRQFNSTIFNSKRWRSTILPTGEGLAMAVKMY
>NZ_AP019860.1|WP_173013559.1|7062968_7066511_+|protein-kinase
MMDHWCIYDKNRKKYGPYSAEQLKAFIQQNKVDDSHIIVNNDKTYNVQQAALELDISPQRKIAKFEIIKELGRGGMGVVYHARDTYLQHECAVKFIHFNQSADSLATKRFISEAQSVAQLDHPNIIKIKELNSYSDAQGNNMYYFSMDYVEGISFAHYIKKPISLKKKLQMFFQICEGVAYAHRHKIIHRDLKPQNIIVSQQGTPVILDFGLARNLQKEENITKTGDFVGTPKYIAPEVMHGKKADQRCDIYALGVMLYEILTGFSPFNGENVIELLFQVSHTDAVPPSKVNGSIKKDTSLEIICLKCLEKNPEKRLSCASFLSQEIQCILANKPTQTKPPGFLAQQVIWCRKNRRLLVATAVIFLLAALAIWTVQNQQHQKEIIARDAQIDVRDAEIFHRSAQSISNNVEQFYEKFSRLKGMKSIVADIKMQYQRLEKYIDNKDHKFLSSQQQNLLNFLERSQAIMRYLVLPSIPKIESSIPIENIDGQFELSTANHIAIVDKDERLFAAKIEDSAQKISFERPLATTCRKLAFSPNGKWLATFELDEEGQKICCLYRTESFQKVLRAKTSNSVRVSFAFSTSSKYFAYHDREHGICIVDLTQNIVSKNIPTDGLACYFKFSDNDKHMIYRLNNDYYYAYNLRSQSTKKKINYVSNLFPLWHDNRFTFFGCDFLESYDPKSKKITKHDFVTVSREDLITSAISPDKKTLIWGSTYGNISYLKKIKNNKFRMTHKKQAQGRIKRIGFLNDQLLFIHDATNYFYVRDLATKEIIYREANVLAVEKVGKRLQVVIRDSEKLLTQRWNIPYALQQILKPNKQTSKILAMAARAVQTQAFIAEPCILVQKDSSIEKVILSLRKALIIWEKQGDLYKHNNAKRTVFFDIWATRISQDHKWIALITGTRNSRQNIILVESDKITPQNIEKGYRIIHGNKLHGKRVDQWKDEFYKTSEIRTLGFTANNNLLFNYADELWRYSRSKKSVKKIIKVRTIIRSIQSHPKHDIIAIGQERDHLAFVSQNGETIHQFSFAGASEIKKIAWHPTKIMCAAISGDSKLYLIQKQNDTWSFEELDVVGRKLNISFSPKGDDLAIFTAGNTYLYSLNTKDYINIFSGFHKNQGATFSRDWQYAVFPSKNMDVLLFSLKKLSEFPEYFATPNMKDKQDNIWSRRVQQKFLQYIEMNK
>NZ_AP019860.1|WP_151970676.1|7066525_7068247_+|hypothetical-protein
MQTLGRFANIDKILFSEDQKSLIVFSNEEVAAFDLNTYEQLETIPTYQKPVDSEKPIDPQDPQYIAKILENRVMSPDGQYYLKAKAWEPVGLYLCSDNTMLTSLSIETYDEANASDYCFSPDGTLVAIGTTEMEFTGSLFVFELKSKQQVACHSCHQCISKVLFFSDNKQIVYSDLDGAIYIYSLEQNKVLYSNKTHSSFLGKLLLSPDDKQVISFCSKDNNLNIWNYGETHKQKPVLNNDGIKLLPCLKDRYLTNIFFSANGERMVTLFSNGSSFLWDSTSMNQITSLIDSNTILLMGSTAIAITFSHDQQKIICAKRDGIYEWSSEDGQLLNRKEENIEHWRRSLFSPDRKILTIFRDDITEWINLETFERKFFEYQPLAYEYAYSHDSKKLVLASESGDLSMMDVYNTETISPFYTSDDSIHAIAFSKDNNYIAVWNSGIVVIDLKSYEVLHKFSYERKHQECVAISPGGQSYELSFCENGKLLFIQNGINVDCWDWRKGNLVETKKGDIWSLENAQYMLVPDGIDMAVKSVVDGKLIKRFPVKLDKYTPHPNGKSWVGWSGKNTLYQLM
>NZ_AP019860.1|WP_151970677.1|7068359_7068812_-|hypothetical-protein
MTQSQVQLEKAFFFVFLCVVFQYLYFTILRIYFQIDISHIGLYCLTAFSATTVLLLLNKLDLQPKTKQIYLKISKVLYSLGGCGFVMGIISLSIPMDGMGPLLFFMLIMISYIPLGIAIVCSYLAQKNGLLFVNILILISPLFVYYLGTL
>NZ_AP019860.1|WP_151970678.1|7069184_7070945_-|cytochrome-P450
METIRIAHLSKLLQGKLIAAEVEGVSLVILKNKEEISIFQGECPHQGALLSEGTIENGAIVCSGHGWRFDCSSGKRVQNSNTCLKKFTACIQDEYVTVKKDEILAWKQQIQKKEMTSSESTTQPFKKLPRPKGVPFLGNILQVDKKRIHVTLEKWADIHGSMYQFQLAHKKIVVVSDPELIGEILRKRPNTYRRLSVMESIFQDMNVRGVFSAEGDRWRKQRRVVMHALNTNHLRNFYPTLVKVTERLKKRWDHSIDSSPKKILLDLMRYTVDVTTNLAFGYDINTLEEKEEVIQQHLEKIFPAIHYRISAPIPYWRFFKLSIDHALDKALDAVRKEIKNIIAHCAQKLAQNPELMENPTNFLEAMMVAREKEDAEFTDDDIFGNVVTILLAGEDTTAGTLAWMMSYMTKYPEVQNKMQQEADAILGDAKVLQNFHDVDKLSYMEAVANETMRLKPVAPLLFMETTKNVDLGGYDIAAGTPIFLLTRHCSLQDDAFTSAREFQPQRWLTPPSSGQSHNLKAFLPFGAGPRFCPGRNLALLEIKTVMAMLCKNFSITSKETLSQNDEILSFTMMPSNLFVSFHQREQ

Crispr_ID: NZ_AP019860_35

• CRISPR_ID: NZ_AP019860_35
• CRISPR_location: 7079734-7079833
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_35

Consensus_repeat	Method
GATTTAGTCCACGGTTCTGGACTTTT	CRISPRCasFinder

spacers of NZ_AP019860_35

>35.1|7079760|48|NZ_AP019860|CRISPRCasFinder
AATGAGGTAAACTTTTCGGGGTTCCCTGGGTATCCTTTCTATACGAAA

CRISPR arrays and Neighbor proteins around NZ_AP019860_35

CRISPR arrays

The CRISPR arrays of NZ_AP019860_35

>merge|NZ_AP019860|35|7079734-7079833|CRISPRCasFinder
GATTTAGTCCACGGTTCTGGACTTTTAATGAGGTAAACTTTTCGGGGTTCCCTGGGTATCCTTTCTATACGAAAGATTTAGTCCACGGTTCTGGACTTTT

>NZ_AP019860|35|29|7079734-7079833|CRISPRCasFinder
GATTTAGTCCACGGTTCTGGACTTTT	AATGAGGTAAACTTTTCGGGGTTCCCTGGGTATCCTTTCTATACGAAA
GATTTAGTCCACGGTTCTGGACTTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970692.1|7090065_7090536_+|hypothetical-protein	unknown	unknown	gnl|CDD|237177
NZ_AP019860.1|WP_151970691.1|7089825_7090065_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970684.1|7079366_7079669_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151970685.1|7080589_7080808_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970688.1|7084194_7085568_+|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341135
NZ_AP019860.1|WP_151970687.1|7082227_7084198_+|N-6-DNA-methylase	unknown	unknown	gnl|CDD|223363
NZ_AP019860.1|WP_151970689.1|7085560_7088692_+|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl|CDD|223683
NZ_AP019860.1|WP_151970679.1|7071171_7073163_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|238697
NZ_AP019860.1|WP_151970694.1|7091162_7091741_+|recombinase-family-protein	unknown	unknown	gnl|CDD|239737
NZ_AP019860.1|WP_151970681.1|7075046_7076255_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013561.1|7076489_7076756_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151970690.1|7088708_7089644_+|hypothetical-protein	unknown	unknown	gnl|CDD|236927
NZ_AP019860.1|WP_151970686.1|7080809_7081679_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013560.1|7073630_7074545_+|DUF559-domain-containing-protein	unknown	unknown	gnl|CDD|367957
NZ_AP019860.1|WP_173013559.1|7062968_7066511_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970677.1|7068359_7068812_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970683.1|7076873_7079144_+|hypothetical-protein	unknown	unknown	gnl|CDD|225913
NZ_AP019860.1|WP_151970678.1|7069184_7070945_-|cytochrome-P450	unknown	unknown	gnl|CDD|365848
NZ_AP019860.1|WP_151970676.1|7066525_7068247_+|hypothetical-protein	unknown	unknown	gnl|CDD|238121
NZ_AP019860.1|WP_151970693.1|7090546_7090978_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970692.1|7090065_7090536_+|hypothetical-protein	gnl|CDD|237177	PRK12704, PRK12704, phosphodiesterase; Provisional.	8.42712e-07
NZ_AP019860.1|WP_151970684.1|7079366_7079669_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	2.48471e-06
NZ_AP019860.1|WP_151970690.1|7088708_7089644_+|hypothetical-protein	gnl|CDD|236927	PRK11551, PRK11551, putative 3-hydroxyphenylpropionic transporter MhpT; Provisional.	0.00068056
NZ_AP019860.1|WP_151970688.1|7084194_7085568_+|restriction-endonuclease-subunit-S	gnl|CDD|341135	cd17246, RMtype1_S_SonII-TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2. This model contains Shewanella oneidensis MR-1 S subunit (S.SonII) TRD2-CR2 and similar TRD-CR's. S.SonII recognizes 5'... GTCANNNNNNRTCA ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases. S.SonII TRD1-CR1 does not belong to this subfamily.	1.47958e-39
NZ_AP019860.1|WP_151970687.1|7082227_7084198_+|N-6-DNA-methylase	gnl|CDD|223363	COG0286, HsdM, Type I restriction-modification system methyltransferase subunit [Defense mechanisms].	3.3815e-78
NZ_AP019860.1|WP_151970689.1|7085560_7088692_+|DEAD/DEAH-box-helicase-family-protein	gnl|CDD|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	3.1103e-86
NZ_AP019860.1|WP_151970694.1|7091162_7091741_+|recombinase-family-protein	gnl|CDD|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	2.70391e-56
NZ_AP019860.1|WP_173013561.1|7076489_7076756_+|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	9.27922e-06
NZ_AP019860.1|WP_151970679.1|7071171_7073163_+|tetratricopeptide-repeat-protein	gnl|CDD|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	1.48941e-20
NZ_AP019860.1|WP_173013559.1|7062968_7066511_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.63306e-91
NZ_AP019860.1|WP_173013560.1|7073630_7074545_+|DUF559-domain-containing-protein	gnl|CDD|367957	pfam04480, DUF559, Protein of unknown function (DUF559).	0.00102759
NZ_AP019860.1|WP_151970683.1|7076873_7079144_+|hypothetical-protein	gnl|CDD|225913	COG3378, COG3378, Phage associated DNA primase [General function prediction only].	7.26446e-56
NZ_AP019860.1|WP_151970678.1|7069184_7070945_-|cytochrome-P450	gnl|CDD|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	1.88766e-80
NZ_AP019860.1|WP_151970676.1|7066525_7068247_+|hypothetical-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	5.18351e-15

Protein sequences

>NZ_AP019860.1|WP_151970684.1|7079366_7079669_+|helix-turn-helix-domain-containing-protein
MVDLSSKGIFQTDTYDAILEQLKKQNALLVKVLEILHRKEGDEKQKYLKVKDVAEILKMSPARIRQLVKQQKLTGIKLGHGEKSHILITRESINRLVSYM
>NZ_AP019860.1|WP_151970683.1|7076873_7079144_+|hypothetical-protein
MVSRNTKDFNQSFAIVKSWFISATDHYGLYIKKAPGRKAHPITAKTLTDEMIYKHIKGEVTIGSYLYNKNRLCERVCIDFDVDTKTKRTFIETGRKETFKLVKGKLYRKVEKTCKVLGAENINYVVEDSVGGFHIWIFFAEPIPVSLAFDFVHSIEKDKTIEKFPKTRELRGKGNFVRLPGRYHSCALGQKREWSKIRNKNEWYSLESPENWTYVTAVRKNSVEKVMKFVRDRRNNFPVKGNNKKDKPLNYTSKIRSLLEKHFGITITKERSFCCPFHSDQKPSGSIYEWNGKELFKCHSANCRMSGKPKSFAQLRRILYQQNVYRPDVKTVQQVVLGNETPKLTIAEIVSRFCKSRNLLYTQGDFWEFGNGVWRKKGKQVIKSDIQKFVGLDFSSKAKIENKYFLIKNYLTKENVLFDKNTDVICLQNGVLNIYTKEFVRHNPDLYLTKRLNFKYNKDIKCPVWMEFLASLDFSTRKIKRLQEWFGYCLSPERKIQKVLYLLGRQSNGKSVILDTLRNLLGDYASCCSLDKLINGRFDSSSLEGKRCNVSGDVEINNKQINAGDFKEFVTGTRQSTERKSIDRYEFVPEFKLAFSANGFLNVSNEDEAFWRRLDIFIFPKVFPENVRDNNLRAKIDGELSGVFNWAIEGLSRLINNGWKFSPCPEVENVDKRKINTVSQVTVHNFLTEFCERDVNKYVAVGELYDKYIEICQKRNSVPLSLSTFGKQIISKKINKARKVLSGKQVCVYLGIKIKK
>NZ_AP019860.1|WP_173013561.1|7076489_7076756_+|helix-turn-helix-domain-containing-protein
MDKDILEVILDKVENIESLLKQKEYNDRFMDVRSVARVLKRSEGTIRRLIQEGKIEGFKIGSGNKQSRYLIPKTFIDNLINQGKGFIE
>NZ_AP019860.1|WP_151970681.1|7075046_7076255_-|hypothetical-protein
MSTLFEHENFFEDYKMKCLHQGGNCKLTDILNIDGTILQDLLPCMDCDYLFDKGKLPRLGIHEKIFLFSLYLEQQKNLFGLSSYLSISNENFLSYKTKFPKRKFDIFKKLTTHKFITKEYIPSGYEIPKKQEYYIPHFEIVDEQLRKGYLYMTPDNVIVEKLDLHRFNKSLPKEMVIQPDRKSNIWHIICGHTNRLLFDVLVSLNPKYTVVTAYNYQNYASWYMTKHYSKKTFAKLTPFAIKLIEDQPLPFINTFLKTFGSQGYTDNAKDKIYKDFVSTDEIYKDFLRQLKYNNLTVTYMEEFSSLRNVSGAQIERFFSKVEKNELSSITRKMNHLNWDAFLKSVNRNPSNEYLTKKFKENCHNQLSTLVSQMQAAQDFTYHQQIVEKAQEVLKLLSSANAF
>NZ_AP019860.1|WP_173013560.1|7073630_7074545_+|DUF559-domain-containing-protein
MVTKTVKVTANNCPYKGRSIQVYDAEIIESLISMYALALAYRQLRENQKHIGERCVFLLKSLVRTALESAIQEACGFIPQVQQTAQNHYSKAISLIQKMGFHCTVDQHIATKKDIASFLNIPISTLNSFLYKHSYEIKPIKLDSPRIRSFGSKASRMNGYHLHDIVKIIFGIDTEVTARIKQEMFGQLGTFAKLDSRSEIEWRSVLKEIFSDFDFKCNHPIGKYRYYVDYFVPELQLCLECNGYDCHRSYDAQKEKEREQIITQNYGLIRFHHKVKLETLVNAILKIKPGSVIRLYDQEKIAQT
>NZ_AP019860.1|WP_151970679.1|7071171_7073163_+|tetratricopeptide-repeat-protein
MQFQKNTPINQHLANLFASQKAVVFAGAGISLEPPAGLPDWNKLRDYTLEAVSSRDAFLQKYFDVLVSVPMIASPGKKGLTPEVVASKISENCYGYFECFRALKDGQPNANHRYLAKMAKNGLLKYIITTNFDVFIEKALEQENIDYVTYRTQEEFASFPQNFRRDTIHIIKIHGCISEPRTITATVEQEAKGLLPVIGDAIELLLADYGFVFWGYSGADLKIDLDYLRMVSASEKAQGFVWNFLELPNYKEPINPNVEKLDAMYGEKAYVVHGKLPDIFDHFIAESDQIERTKYSAEEEKSWREQKNVRFKNALTEWATQHLQQVDASSIYGRLLQHSGKTQEAIECLEHQLKICQDNSGSELEIAKITNNIGLVYHGVGEYHKALDYFEKAKEIAQKTGSETELARSLNNLGLIYSVQGKLDDALAVYLKVLDMNRKAISKKNMGSLLGNIGMIYHDKKHHEQALKYLQEAVEIARELGDKYSLATRLNNIGSVCSNQQKHDEALKYYLESLEITRILGDKKGLGRQLNNIGAIYYHQKKYYDAVGYYVEAEKICKEIGDKKILGTIYSNRASIFLAFKNFNEGLNYAQKGLDIMVEIGDFPMAAATCETMGIIHEDVLRDYAKAIKCYEESIQYYTRIGRTDKTSEMPQWIAECRAKGSL
>NZ_AP019860.1|WP_151970678.1|7069184_7070945_-|cytochrome-P450
METIRIAHLSKLLQGKLIAAEVEGVSLVILKNKEEISIFQGECPHQGALLSEGTIENGAIVCSGHGWRFDCSSGKRVQNSNTCLKKFTACIQDEYVTVKKDEILAWKQQIQKKEMTSSESTTQPFKKLPRPKGVPFLGNILQVDKKRIHVTLEKWADIHGSMYQFQLAHKKIVVVSDPELIGEILRKRPNTYRRLSVMESIFQDMNVRGVFSAEGDRWRKQRRVVMHALNTNHLRNFYPTLVKVTERLKKRWDHSIDSSPKKILLDLMRYTVDVTTNLAFGYDINTLEEKEEVIQQHLEKIFPAIHYRISAPIPYWRFFKLSIDHALDKALDAVRKEIKNIIAHCAQKLAQNPELMENPTNFLEAMMVAREKEDAEFTDDDIFGNVVTILLAGEDTTAGTLAWMMSYMTKYPEVQNKMQQEADAILGDAKVLQNFHDVDKLSYMEAVANETMRLKPVAPLLFMETTKNVDLGGYDIAAGTPIFLLTRHCSLQDDAFTSAREFQPQRWLTPPSSGQSHNLKAFLPFGAGPRFCPGRNLALLEIKTVMAMLCKNFSITSKETLSQNDEILSFTMMPSNLFVSFHQREQ
>NZ_AP019860.1|WP_151970677.1|7068359_7068812_-|hypothetical-protein
MTQSQVQLEKAFFFVFLCVVFQYLYFTILRIYFQIDISHIGLYCLTAFSATTVLLLLNKLDLQPKTKQIYLKISKVLYSLGGCGFVMGIISLSIPMDGMGPLLFFMLIMISYIPLGIAIVCSYLAQKNGLLFVNILILISPLFVYYLGTL
>NZ_AP019860.1|WP_151970676.1|7066525_7068247_+|hypothetical-protein
MQTLGRFANIDKILFSEDQKSLIVFSNEEVAAFDLNTYEQLETIPTYQKPVDSEKPIDPQDPQYIAKILENRVMSPDGQYYLKAKAWEPVGLYLCSDNTMLTSLSIETYDEANASDYCFSPDGTLVAIGTTEMEFTGSLFVFELKSKQQVACHSCHQCISKVLFFSDNKQIVYSDLDGAIYIYSLEQNKVLYSNKTHSSFLGKLLLSPDDKQVISFCSKDNNLNIWNYGETHKQKPVLNNDGIKLLPCLKDRYLTNIFFSANGERMVTLFSNGSSFLWDSTSMNQITSLIDSNTILLMGSTAIAITFSHDQQKIICAKRDGIYEWSSEDGQLLNRKEENIEHWRRSLFSPDRKILTIFRDDITEWINLETFERKFFEYQPLAYEYAYSHDSKKLVLASESGDLSMMDVYNTETISPFYTSDDSIHAIAFSKDNNYIAVWNSGIVVIDLKSYEVLHKFSYERKHQECVAISPGGQSYELSFCENGKLLFIQNGINVDCWDWRKGNLVETKKGDIWSLENAQYMLVPDGIDMAVKSVVDGKLIKRFPVKLDKYTPHPNGKSWVGWSGKNTLYQLM
>NZ_AP019860.1|WP_173013559.1|7062968_7066511_+|protein-kinase
MMDHWCIYDKNRKKYGPYSAEQLKAFIQQNKVDDSHIIVNNDKTYNVQQAALELDISPQRKIAKFEIIKELGRGGMGVVYHARDTYLQHECAVKFIHFNQSADSLATKRFISEAQSVAQLDHPNIIKIKELNSYSDAQGNNMYYFSMDYVEGISFAHYIKKPISLKKKLQMFFQICEGVAYAHRHKIIHRDLKPQNIIVSQQGTPVILDFGLARNLQKEENITKTGDFVGTPKYIAPEVMHGKKADQRCDIYALGVMLYEILTGFSPFNGENVIELLFQVSHTDAVPPSKVNGSIKKDTSLEIICLKCLEKNPEKRLSCASFLSQEIQCILANKPTQTKPPGFLAQQVIWCRKNRRLLVATAVIFLLAALAIWTVQNQQHQKEIIARDAQIDVRDAEIFHRSAQSISNNVEQFYEKFSRLKGMKSIVADIKMQYQRLEKYIDNKDHKFLSSQQQNLLNFLERSQAIMRYLVLPSIPKIESSIPIENIDGQFELSTANHIAIVDKDERLFAAKIEDSAQKISFERPLATTCRKLAFSPNGKWLATFELDEEGQKICCLYRTESFQKVLRAKTSNSVRVSFAFSTSSKYFAYHDREHGICIVDLTQNIVSKNIPTDGLACYFKFSDNDKHMIYRLNNDYYYAYNLRSQSTKKKINYVSNLFPLWHDNRFTFFGCDFLESYDPKSKKITKHDFVTVSREDLITSAISPDKKTLIWGSTYGNISYLKKIKNNKFRMTHKKQAQGRIKRIGFLNDQLLFIHDATNYFYVRDLATKEIIYREANVLAVEKVGKRLQVVIRDSEKLLTQRWNIPYALQQILKPNKQTSKILAMAARAVQTQAFIAEPCILVQKDSSIEKVILSLRKALIIWEKQGDLYKHNNAKRTVFFDIWATRISQDHKWIALITGTRNSRQNIILVESDKITPQNIEKGYRIIHGNKLHGKRVDQWKDEFYKTSEIRTLGFTANNNLLFNYADELWRYSRSKKSVKKIIKVRTIIRSIQSHPKHDIIAIGQERDHLAFVSQNGETIHQFSFAGASEIKKIAWHPTKIMCAAISGDSKLYLIQKQNDTWSFEELDVVGRKLNISFSPKGDDLAIFTAGNTYLYSLNTKDYINIFSGFHKNQGATFSRDWQYAVFPSKNMDVLLFSLKKLSEFPEYFATPNMKDKQDNIWSRRVQQKFLQYIEMNK
>NZ_AP019860.1|WP_151970685.1|7080589_7080808_-|hypothetical-protein
MSHYNRQIHNKHQRLNKKIAPAGKSIPQLIEDAISGKEYLSIQIHKANTEVQVEYQPNARGGKDDLSIRIKN
>NZ_AP019860.1|WP_151970686.1|7080809_7081679_-|hypothetical-protein
MPKQLLFLSWGSSNPKVKKCNLELGYLTAILNLSPHYESQVQVSDKETFRKWIGIYENYYNVCPFSSRGCRQHCLHYSGRSKVFEHISRKRMQRTRMLLVDPAYALQQIIKDIRIVVSEANKNDKLPAIRLNGTSDLAWECLYFYPDFKPRCGSILIETNPSDAKRLGAINIFDLFPGVQFWDYTKRSDRCFTSLPDNYSLTFSKSEANDLYCQRILQRKHANVAVVFRDHKPKTYWGHQVIDGDEHDLRFLDSDPQDNPVIVGLKAKGDSSEDQSGFVVDVTDSQRKE
>NZ_AP019860.1|WP_151970687.1|7082227_7084198_+|N-6-DNA-methylase
MSDSSFSSTAAFIWSVADLLRGDYKQSDYGKIILPFTLLRRLECVLEPTRDKVITKHEQLKDSSIPSHDFLVREAEQSFYNTSKLALATLGQKDIGENLVKYVDSFSEDARDVFERFKFRDQIDFLAAKNLLYQIVEKFKNIDLHPETIDNYHMGLVFEELIRRFAEASNETAGEHFTPRDIVRLTTSLVLMPDDEAIAGSGVIRTIYDPTSGTGGFLSTATEYVHELNSQAVIRVFGQELNDESYAICKADMMIKGQDVSNIKQGNTLSEDKLWGEKFDYMLSNPPFGVEWKKVQKVIQEEHTQKGYDGRFGPGLPRVSDGSLLFLMHLISKMHDSRDGTSRIGIILNGSPLFTGGAGSGESEIRRYILERDLLETIVALPTDMFYNTGIATYIWILSNNKSEERKGKVQLVNATELFAKMRKSLGSKRNYLTEEHIAEITRTVGNFVESDTCKVFANKSFGYRRITVERPLQLKFAISEEKINELTQEKAWGKIKGEIQKNIINALEQLVGKEYNSREQFMIAFEQVREDKKLSASQLKFVWSNLGERCEDAEICRDKKGKIEADSELRDHENVTLTENIEEYFAREVKPHVPQAWIDEKKKDDKDGLVGVVGYEIPFNRHFYKYTPPRSLQEIDHDLDQVTKKILELLKEVHS
>NZ_AP019860.1|WP_151970688.1|7084194_7085568_+|restriction-endonuclease-subunit-S
MSYQPYPEYKDSVMPKTTKIPNHWSLEKIKFNSYVKGRVGWQNLRKDEYTELGPYLVTGAHFDKKDGVNWEACYHVSEERYQLDKDIWIKKNDLLMTKDGTIGKIAHIKELPGKACLNSHLLIIRDLQQKYIARYAYYLLISPVFKVFVALRQSGTTFHGITQEAVEEFKLILPPLLEQKAIATFLDRETAKIDKIIAKQQKLIELLQEKRQAVISHAVTKGLDPNVKMKDSGVEWLGEIPEHWDSIKLKLLTVLLKDGTHSSFKRVDEGYRLLGVRNIRNDLFIFRDDDSKISEVDFKTITKSFLVMSGDIQLGIIGGIGKVALVQKLKEKFATQRNVATIRVNKRVINKFLFYFFKSFMFQNYLLKNAGYSAQPAVYLGTLGSCNISTPSLTEQKNIITYLNQKTAKIDVLINKTQTAIALLKEKRIALITAAVTGKIDVRNEVTPKEIEEAQND
>NZ_AP019860.1|WP_151970689.1|7085560_7088692_+|DEAD/DEAH-box-helicase-family-protein
MTDREKEQDFENDIVSKLTQNNWEEGKSSNYNKDLALYPEDLIGFLKDTRPKEIAKLQQFYKDETETSICQMVAKQMQKHGALKVLREGVKDRGAKLKLCQFKPEHQANPDLLDHYQKNRLRVVRQLYYSKHNNNSFDLVLFVNGIPVATVELKSDVTQSIDDAVNQYKENRLPKDPKSNKEEPLLVFNKRVLVHFAVSSTEVYMTTKLAGKDTFFLPFNQGNNGGAGNPPNSDSYPIAYLWEKIWQKDAWLDILGRFIHLKSEKKEDINGKKTIKETLIFPRFHQWEAVTNLLAAVKKEKAGHTYLIQHSAGSGKSNSIAWTAHQLSALHDENDKKIFDGVIVVTDRTVLDNQLQGTISSINHHKGVIAHINRKDSNSKSTQLSQALTEEKAIIIVTIQTFPFVLDEIRKQKSLREKNFAIIADEAHSSQTGKAAKKLIETLTTEYIDENSEISAEDMLTMSITSLKEAKNISYFAFTATPKEKTIQLFGRAPNPDAPINKDNLPAPFHVYTMQQAIEEGFILDVLRNYTSYEMAYQLAHKDPQHDTNEIETKRAKSQIYRWLKLHPHNISQKVQIAIEHFRCHVAHLLNGQAKAMVVTGSRKEAVRYKQAFDAYIEENNYDNVRALVAFSGTVKDEDQEFSERSMNPGLNRRSLRKAFDSNDYQVMLVANKFQTGFDQPKLCAMYVDKSLGGVACVQTLSRLNRTYPGKNEVFILDFVNNAEEVRAAFEPYYRTAELTDMSDPNLVYDMQDKLNASRLYTLEEVDAFAIAFYDPKNKTQEKLESIIQPAVDRFNNRYKQTRDELLNLERNLHYAKKDKDKIRIGNIQVEIKETREQIDELKIFKRDLGSFSRYYEFVSQIIAFGDTDLEKLNIFSRFLFRHLKTEKTSDPINLNDVVLTHYRLSKLQQHAIKLEAEQKLQPTNALGSAKGKDPKKDRMSQIIQQINDLFRDADLMENYSLSYFSALTDILVQDKQIIDQVKNNPKDKVMKGNLPGATKNAIMDSLTAHETMATMLLQNEELKKRFDNLIYEWLDHKLKDAT
>NZ_AP019860.1|WP_151970690.1|7088708_7089644_+|hypothetical-protein
MIYKNDKELSVIILLIKQARFFLENPKKQMAEMPEEVEQLLSFAEGVDMGTTGAGAAGLGIGATISLAALYSAGITGLSAAGIASGLAAIGGSMLGGIAALAALPVAVGIGSALAYKWLTSESLEDKKKRLLGDLEKIQPEMKVKIKCSDKAIANQAYNFYVLIYGAMNDLRQDLGMEPLREIEQIAQRPEVSKVENEIDLANDDPKQEEIEKKSDDKNQKLVREIYPKGSLPEPDNIVNKNIGHKDKLLIEELIETQSQATEKNETPNNEQTSQNKKSLAEELRELKAIWEEDLITDEEYSAKKKQILGL
>NZ_AP019860.1|WP_151970691.1|7089825_7090065_+|hypothetical-protein
MSQGQSKKDDQQKLIQEQKSKIKEQERVISDLTNKLEKTKKIFLLLLCVTLMTIAMFIHKDYQHKQELKEILSKMGEKD
>NZ_AP019860.1|WP_151970692.1|7090065_7090536_+|hypothetical-protein
MKDNSSTDKIANIFTIIAGIFTIIGTIWAIFVYFAPSQKEMYLKDIYKSIEVRQETIRKNEEEIMALKSENYDLKKSNERLQKESSRLDKENDRLGKENDRLNEENESLTGSNKNLQKEIKKKNQKIERLKTHNKKLKQEIQKLKKALMEKKNTGP
>NZ_AP019860.1|WP_151970693.1|7090546_7090978_+|hypothetical-protein
MEYLYYLYNNIDVIRDWVNLAFIAIPTVMAIFAIYSAMEHGKQYNEMNSSKKRGAAAVKNKYMKEKFKAGKIYLIAISCLCVYIVVVRIQYQLAEKKIQQLESSYKTDVEEAIKVEKRLLKMELQAIKSENEKLKTQLKKSQK
>NZ_AP019860.1|WP_151970694.1|7091162_7091741_+|recombinase-family-protein
MLIGYARVSTEDQNLDGQVDQLQKIGCEKIFKEHASGTSKDRKELAKAVDQLRKGDTFVVCSLDRLGRSVKQLIEFVNDLKKIGVAFRSIREAIDTETPTGKFFFHVTAAFAELERNLIQERTKVGLAAARARGRKGGRKRVIDDKKFQIALQLYEENKTPVTDICKSLGIAKRTFYRYLEEHKQRSHLSKT

Crispr_ID: NZ_AP019860_36

• CRISPR_ID: NZ_AP019860_36
• CRISPR_location: 7174866-7174969
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_36

Consensus_repeat	Method
ACTTACAAATCCATGTCATTCACGCGTAAGCG	CRISPRCasFinder

spacers of NZ_AP019860_36

>36.1|7174898|40|NZ_AP019860|CRISPRCasFinder
CATGGCTATCAAGTTAAGCGTGAAAGCTTTCTTAATAAAG

CRISPR arrays and Neighbor proteins around NZ_AP019860_36

CRISPR arrays

The CRISPR arrays of NZ_AP019860_36

>merge|NZ_AP019860|36|7174866-7174969|CRISPRCasFinder
ACTTACAAATCCATGTCATTCACGCGTAAGCGCATGGCTATCAAGTTAAGCGTGAAAGCTTTCTTAATAAAGACTTACAAATCCATGTCATTCCCGCGTAAGCG

>NZ_AP019860|36|30|7174866-7174969|CRISPRCasFinder
ACTTACAAATCCATGTCATTCACGCGTAAGCG	CATGGCTATCAAGTTAAGCGTGAAAGCTTTCTTAATAAAG
ACTTACAAATCCATGTCATTCCCGCGTAAGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970760.1|7179735_7180887_+|hypothetical-protein	unknown	unknown	gnl|CDD|238430
NZ_AP019860.1|WP_151970757.1|7177834_7178047_-|cold-shock-domain-containing-protein	unknown	unknown	gnl|CDD|224197
NZ_AP019860.1|WP_151970752.1|7172872_7173823_+|hypothetical-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_173013567.1|7170945_7171791_-|2'-5'-RNA-ligase-family-protein	unknown	unknown	gnl|CDD|379265
NZ_AP019860.1|WP_151970749.1|7166275_7169794_+|hypothetical-protein	unknown	unknown	gnl|CDD|274009
NZ_AP019860.1|WP_151970762.1|7181916_7182651_+|3-oxoacyl-ACP-reductase-FabG	unknown	unknown	gnl|CDD|187594
NZ_AP019860.1|WP_151970747.1|7163045_7164437_+|DUF3482-domain-containing-protein	unknown	unknown	gnl|CDD|371831
NZ_AP019860.1|WP_151970751.1|7171826_7172789_-|hypothetical-protein	unknown	unknown	gnl|CDD|213029
NZ_AP019860.1|WP_173013566.1|7159271_7160369_+|gamma-glutamylcyclotransferase	unknown	unknown	gnl|CDD|119400
NZ_AP019860.1|WP_151970759.1|7179070_7179739_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970758.1|7178519_7178732_-|cold-shock-domain-containing-protein	unknown	unknown	gnl|CDD|224197
NZ_AP019860.1|WP_151970755.1|7176015_7177017_-|hypothetical-protein	unknown	unknown	gnl|CDD|367273
NZ_AP019860.1|WP_151970763.1|7182660_7184262_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224154
NZ_AP019860.1|WP_151970754.1|7175177_7175762_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_AP019860.1|WP_151970756.1|7177089_7177653_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970745.1|7160399_7161362_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970761.1|7180886_7181912_+|beta-ketoacyl-synthase-chain-length-factor	unknown	unknown	gnl|CDD|379349
NZ_AP019860.1|WP_151970748.1|7164494_7166144_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970753.1|7174080_7174815_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|181335
NZ_AP019860.1|WP_151970746.1|7161529_7163053_+|DUF2868-domain-containing-protein	unknown	unknown	gnl|CDD|378549

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970757.1|7177834_7178047_-|cold-shock-domain-containing-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	9.43493e-30
NZ_AP019860.1|WP_151970755.1|7176015_7177017_-|hypothetical-protein	gnl|CDD|367273	pfam02958, EcKinase, Ecdysteroid kinase. This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates.	8.76469e-09
NZ_AP019860.1|WP_173013567.1|7170945_7171791_-|2'-5'-RNA-ligase-family-protein	gnl|CDD|379265	pfam13563, 2_5_RNA_ligase2, 2'-5' RNA ligase superfamily. This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	7.67874e-24
NZ_AP019860.1|WP_151970749.1|7166275_7169794_+|hypothetical-protein	gnl|CDD|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00280139
NZ_AP019860.1|WP_151970762.1|7181916_7182651_+|3-oxoacyl-ACP-reductase-FabG	gnl|CDD|187594	cd05333, BKR_SDR_c, beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs. This subgroup includes the Escherichai coli K12 BKR, FabG. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet) NAD(P)(H) binding region and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H) binding pattern: TGxxxGxG in classical SDRs. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P) binding motif and an altered active site motif (YXXXN). Fungal type type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P) binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr-151 and Lys-155, and well as Asn-111 (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.90682e-105
NZ_AP019860.1|WP_151970747.1|7163045_7164437_+|DUF3482-domain-containing-protein	gnl|CDD|371831	pfam11981, DUF3482, Domain of unknown function (DUF3482). This presumed domain is functionally uncharacterized. This domain is found in bacteria and eukaryotes. This domain is typically between 289 to 301 amino acids in length. This domain is found associated with pfam01926. The central region of these proteins contains a hydrophobic region that is similar to pfam05433.	7.00873e-40
NZ_AP019860.1|WP_151970751.1|7171826_7172789_-|hypothetical-protein	gnl|CDD|213029	cd11375, Peptidase_M54, Peptidase family M54, also called archaemetzincins or archaelysins. Peptidase M54 (archaemetzincin or archaelysin) is a zinc-dependent aminopeptidase that contains the consensus zinc-binding sequence HEXXHXXGXXH/D and a conserved Met residue at the active site, and is thus classified as a metzincin. Archaemetzincins, first identified in archaea, are also found in bacteria and eukaryotes, including two human members, archaemetzincin-1 and -2 (AMZ1 and AMZ2). AMZ1 is mainly found in the liver and heart while AMZ2 is primarily expressed in testis and heart; both have been reported to degrade synthetic substrates and peptides. The Peptidase M54 family contains an extended metzincin concensus sequence of HEXXHXXGX3CX4CXMX17CXXC such that a second zinc ion is bound to four cysteines, thus resembling a zinc finger. Phylogenetic analysis of this family reveals a complex evolutionary process involving a series of lateral gene transfer, gene loss and genetic duplication events.	3.05984e-54
NZ_AP019860.1|WP_173013566.1|7159271_7160369_+|gamma-glutamylcyclotransferase	gnl|CDD|119400	cd06661, GGCT_like, GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).	5.35365e-16
NZ_AP019860.1|WP_151970752.1|7172872_7173823_+|hypothetical-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	1.10693e-33
NZ_AP019860.1|WP_151970763.1|7182660_7184262_+|FAD-dependent-oxidoreductase	gnl|CDD|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	2.49736e-53
NZ_AP019860.1|WP_151970754.1|7175177_7175762_+|TetR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.69836e-13
NZ_AP019860.1|WP_151970758.1|7178519_7178732_-|cold-shock-domain-containing-protein	gnl|CDD|224197	COG1278, CspC, Cold shock proteins [Transcription].	2.46168e-29
NZ_AP019860.1|WP_151970761.1|7180886_7181912_+|beta-ketoacyl-synthase-chain-length-factor	gnl|CDD|379349	pfam13723, Ketoacyl-synt_2, Beta-ketoacyl synthase, N-terminal domain.	1.02985e-19
NZ_AP019860.1|WP_151970760.1|7179735_7180887_+|hypothetical-protein	gnl|CDD|238430	cd00834, KAS_I_II, Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP.	3.72451e-140
NZ_AP019860.1|WP_151970753.1|7174080_7174815_+|SDR-family-oxidoreductase	gnl|CDD|181335	PRK08264, PRK08264, SDR family oxidoreductase.	6.04754e-105
NZ_AP019860.1|WP_151970746.1|7161529_7163053_+|DUF2868-domain-containing-protein	gnl|CDD|378549	pfam11067, DUF2868, Protein of unknown function (DUF2868). Some members in this family of proteins with unknown function are annotated as putative membrane proteins. However, this cannot be confirmed.	1.29329e-44

Protein sequences

>NZ_AP019860.1|WP_151970753.1|7174080_7174815_+|SDR-family-oxidoreductase
MSYDIKDKVTLVTGANRGIGKAIVESFIAYGVKKVYAAVRKLESANELIEKYGDKVVAVEIDLGKPQTIISAAEQVQDVEVVVNNAGVLALSNPLSENALESLKFEIDINLFGLVRIAQAFAPVLQKNGGGAFVQLNSVVSLKSYPDIATYSASKAASYSITQSLRSALKEQNTAVLSVHPGPIATDMAEDAGISDIAEPVTVVSEGIINSLKSGDFHLFPDTIARDLGEKYQSFAQNAILAEE
>NZ_AP019860.1|WP_151970752.1|7172872_7173823_+|hypothetical-protein
MNAILKEIETARKYNETNLELCGMNLKEFPMEVLQMPELESLNLASNEISSLPPQITQLTNLTKLNLSLNRLKEVPQQICELKNLMFLDLKDNMLKTLPEEITQLVNLQVLLLRANMFKEFPQPLLKMKSIGALDLSENFIGEIPPQISHLQNLESLALHRCSLQSLPSQIASLEKLKVLLLSDNNLQQLPQGMSRLTKLTHLFLYENSLVELPQVEFFPHLQYLNIAYNELQFLPSFADLVLLEELYANGNQLQEVPAGIGKLQQLKKLDLSQNKIRSVPLEINELSDLEGLDLKGNELTSPPDFSGLRCEYLEY
>NZ_AP019860.1|WP_151970751.1|7171826_7172789_-|hypothetical-protein
MKTYVFTIVVLSLLTLACSQENKLPSQKQYYKDVSSLDEKLQRHHFRAVDELQKPFLSLIEKHKIFHPGGMHDWYPSHKEPGQTFFQYKKRQKNSKLTTIYIQKLGDFSQEQKQVVALVTRYISSYFQVPVKFTKPIPLSKIPRSARRIHPSWGDKQILTTYILRKVLYPNRPKDAIAYIALTGTDLYPRESWNFVYGQASLTHRVGVFSMYRNGDPSSSKELFLRCFLRTAKTATHEIGHMLGMKHCIAFACCMNGSNNREESDRGPLWLCPVCLCKLQWFLPVDLQKRYDELAAIVQSLGFHTRAQFFRDSITLIDKK
>NZ_AP019860.1|WP_173013567.1|7170945_7171791_-|2'-5'-RNA-ligase-family-protein
MVDKSMTTGVKGLTKILMPSQHWKTNNIHQLRFDLTVGWPPKLEAPHITLLDPIAADDRFEDMRKHLCEALKDFPVFTVKLSKFDFFRHRRRGYTLYLVPEVNPQNALRELQSAISTACTNLHFLENKISRGFNPHVSIAKIADEKTLHNTMEKLQKNWKPIEFQVQEIYIMSKLLHDTVVRHVVPFSANTTPNFSPIPFSQYGQHSININHVPLGTTKKQLLNTFQQLDALKARVTFKTTGSQKQKGWGHVIFPSKEKRDQALHHDFYIDENLLEIFPCD
>NZ_AP019860.1|WP_151970749.1|7166275_7169794_+|hypothetical-protein
MKKSILLLCIMWIPIFAEYAMTINKVEVAAKKPNGKSWDALGKPDLIISIYKWNGKVWQKKFTSAKLSNVLKVEKEIDTKINVVAGDKIKITIEDSDLRNNDAIGLKELTITKEHITAGTISTSFSSVVAFHAKLKMTPLSYKEKRLLQDVAYFLNAAGNTDDSSVANKYLQQAKDKIAEMPASRATHPSIKEYQQKIADAKVKIETKKQRFSYQDSKKLNNVKYFLDNAQKSNDAEVIKKYLAQAESDLEALVEKHAQHEKVLGLVKSFKELQNKVNEATKPKVQENTNTTTAPKKEELTYREKRALGNVRAVLSNIDRLTDPDVLRSSIKNAQYQMTDLQNKTDHPEVQALQKQIDAQQQRLKDIVAAKNNTNTTTTVPEKKEELTYREKRALGNVRSILSNMDRINDPDVLRSSIKNAQSQMTDLQNKADHPEVQALQKQLDAQQQRLKDIVAAKNNTNTTTTTAPKKEELTYREKRALGNVRAVLSNMDRITDPDVLRSSIKNAQYQMTDLQNKTAHPEVQALQKQLDAQQQRLKDIVAAKNNTNTTTTTAPKKEELTYREKRALGNVRAVLSNMDRITDPDVLRSSIKNAQYQMTDLQNKTAHPEVQALQKQLDAQQQRLKDILAAKNNNNTTTTPDNTHTPKELTYRQKKAIKNLKATLASTGRVKDVDVLRSMLKNTSYYTGDLESVRNHPQVKPLFEQIAALEKRIADTANSAQRALIDRVLGIVGKGLKATDNMLLLCKYKFNQDKIIEVGKSLEKENPSVRSYFQDIDRGGRYLDSAIDSVLSALREDTKKALEIENSPYDPRYKALLLHEEIAPKFNEMKSKLSDAATRINDLSNERFADVEQVIKQRDQWNKGPRTFNQPLETYFQQNKKLIAVLGAGIALSPQIEKWCKNIEANSKKALEYKEFLGLCDSIRNITENNQEDFKRSQIADAKKKAQGNALLQQFLDYYITYADIYNEIDGTLKQLKQDLLGRIETASQKAAQQGFDTFRDQYTQAKANRMDMLNNPENYEGKIIANAKFPVASWNTKGWFLQHGNEMFSYVWDPQLWKRFREIELAEFKIFRDFRAGILQKYEMTKEGHIDWKYPGLVDIEFVAIVDGTTSYTPTREVLDSRGRVIWIEKLPPIQIVNARVVGVKSRYFTLWLGGTDTLKHLDTGGLPRK
>NZ_AP019860.1|WP_151970748.1|7164494_7166144_+|hypothetical-protein
MKNKFLVLLGLFWVSIFVFLVFQGVQPRDTSDNEQNLQDTEERVGGVKEVVVTEEENTEPQLEDGEVVEEISPSQDTALKPKELPKKPIVQNLNKLQKQQEEKRSANVTRIEIFPQKVTLKPGGSDIFTATAYNAQEQPVSFSGKWSTNAGKIEYMASNKIKLTTYRSLQSTGWLRCTDKKTLANGDAFIDITEIPRLSRFSIEGLPGTLNAGESCDLRVVAYDQFGDRFPIKPEWNTPAGTISAEGHFVVGNKYGRHEIRLRDRNSGQSISRFVHIQAPLKVIDLYGTEKSLRPGETFQYRAVCFDRYRNEINFPVKWSATGGQVDANGNLTPGEIPGTYEIFVEGIGTDIRVGMYYKIIPIIKSIKIVNIPPFIYGGDRHVFQAVGYDYQNRPLYFEPVWKAGGGQINANGEFLAGNQPGTYNVTVSDGYGVEQTASFVIKAEITEKDFELTGDVLFEDGERVVSIQHATVTIFKTGRFIISYQVRVFQEKSWNYQLLFRLQNNNIFEVNPATVKKRPGQFNFTQRGRSQTIRRTFRNIRAVDARFR
>NZ_AP019860.1|WP_151970747.1|7163045_7164437_+|DUF3482-domain-containing-protein
MSDTPVFIIMGQSNEGKSSIVSTLVGHDKVEVDHDAGTTKEYRVFPIEIDGERIMDFIDTPGFEHPKKILKWLRKNENSYENSKNLISAFCDMHHKKKNLELDCQLLAPIKNYMEACILYVFDGSRPVDQQDIWAMEIVSMSGCGRIALINCRKDSEEHIDKWKNECSKYFNSVKNFNAHRANFKDRVRLLTTMGTLVDNLADTLELVTENLKQQRDRLYKEIAEHISDKLRKCIAFSTKGNTIGDIKTLKQKLIISYKKGIEKIESEFRKEVRSVYRHRIFDVEIPQKSIINEELFSEETWSVLGLTKNQLTFAAAAGGTGIGLGISALLAPITGGASLAVGGLLGAAAAATAHFKGEDMFDVSVGKQQHVTIANKKIQFYYILVDRMILYYSYMVNRAHGKRVETKVKVEDGEKQGFTSKWTQEQQQQFKTWLQDTIKGNHSDVAVEEIIVPMLKEIDGKE
>NZ_AP019860.1|WP_151970746.1|7161529_7163053_+|DUF2868-domain-containing-protein
MWKIKDFIDLEYFFYTDREKDQENLIKRDRLLFVNEIEEMCKDKPTQIKKWLELRRSQEDDLEELPGDIYNNSYLLLKNILIFVGIISGFALTNSFLWYDGKMPINVSAFFFVLIILQMLLLIAAFFVFLLRNKLRSLTFLSPIIKRLLKRLALFVLKNTYHKLSSKNAKNFEAKMGFIRSQKLIYGRLFKWQIFNATQLFAIFFNIAILLTLLFKVFTADLALGWQSTAEIQSEVLHKTVKVIATPWSWCMEQHAYPSLEEIEGSRIILKDGIYHLQSEHLASWWPFLCLSILFYGLLPRLLFLFIGYFAQRRSVAHFDFNHANCQRLVRRFVTQYVEIDGNSTNVAQENQQHQTTEISNIEIKKVEKTAQSEYKILLWESIAKLYADGYLQQQVQKKLTYKNEIYMIESSLEGEDKAIDYIENSHCDGIVVLQAAWKPPIGEAVEFISDIRETIAQKEIIVALLGKPVDGEQHKVDKNDYKMWTNAIAKLGDPYTSVVCLGEKDE
>NZ_AP019860.1|WP_151970745.1|7160399_7161362_-|hypothetical-protein
MFLLRIYILFTATMLKMMVLIVLMALLCDMVRMIPAYATALTHGDFWEDANEYATGEQSLEQLTAKYGKNFTKIASGAFWMFLPSEKTITFHLTLATKSGGSITQILVLMIFFYILFRITISWYAKQCCCENDPFLLYHEYFYTTSIAHKLSILTSAIVVLVISYINASLETQYTHLSFHELVAVYFVLSYTSAIWFLVIKYIIDIQYIEQNRNPHDMYRDDVIAVILTIGILFFFSNSFLSILSEIIAGVLPFVLVKTIRFNVPNSKLLEEKDSLVYKYEEAMGMHSTIYREISLALIGVVILAVIIGQIFMADGLMWS
>NZ_AP019860.1|WP_173013566.1|7159271_7160369_+|gamma-glutamylcyclotransferase
MSTKIDDKTKISGHTTVGDWKSLRLTLLKNIQELPEDAWEKAYEIFDWRIRSRFLDPIDSILEKDLKGGEGFTIVAIQCILIEFLEAFYQGKTYTIKHKDLWVHEYVSSKQLFKDFLLNHTPFKDYFTEKLANVFYSNIRCGLLHEAQTKETSKIRASSRENLIKALDDGNMIIYRTNFQQAILQYIENYKRQLAQDLQLRRNFIRKIDELCGIEHVYYFAYGSNMKLERLLKRLQSGDEPAKIHNYCVVYLENHKFTFNKKGKDGTAKANVFVEEEQEVWGVCYEVDKSALPILARYEGGYDQSYVNVKTKNNKPMRAITYISKSVFSAPQLPSDEYYQKVLEGAQEQGLPEDYIVCNITNHMR
>NZ_AP019860.1|WP_151970754.1|7175177_7175762_+|TetR-family-transcriptional-regulator
MPRLKEYHKEDVLHAAMNVFWEKGFHGTSVNDLVKATGLNKHSMYKEFGNKEGLFKACIDNYVGEAMKDNMSILLRKPLGFENIKAFFYNCIDILTNKQCKSCFLVNSVAEKEVLNEEINSCVKMHLVAQEKVFYDCLQASQQRNEIAADKDLETHARLLMCFLEGMSITGKIHHDRESLHKMVERVFSLVTSS
>NZ_AP019860.1|WP_151970755.1|7176015_7177017_-|hypothetical-protein
MVLESTSQITKEWLQQTINQFYPQAQIKNVTLNCGNSRHANNAIINIEYCEDHHSYPTSFFLKICQNCAYFITDSEYDYYKKDYVDLKNAPIPVCYDAQYSESGYHLLLEDLSATHYSNQDIEPTQQHAIELAKELARLHAFYWQEDSPISAVDKYIEKTSQGLPAIFSHTSLSQQDKISIGNIIENCGQKFYERQQYRNGFTKIHGDANPCNVMSPYDKKGKTYIIDRQPFLWSLTHFLGMYDLVYATIPCWETDKRRSFEMTTLQTYHRNLQKFGVQNYSWEQCLDDYRLCIILAFYVPISWGLSEKSMKEMQWLWEKQLRRLLQASRDWS
>NZ_AP019860.1|WP_151970756.1|7177089_7177653_-|hypothetical-protein
MDTIHKTIDIKLIQEYFQVAKSTAYYWLRNAVLDTIGDGRRIALINKKFYKLAKKRDLPLFHRWVKKLRGKIIVVSSHHTIVEESLKEKLYKNQLDHGAIVDYLIENTAWLREQIPFSIIYVNCEGKKYIRNLNWIQLAKLSKTHTISTRKGKEVNFRQYLHQLSHYDNPRDRYLKYKALAALTIFG
>NZ_AP019860.1|WP_151970757.1|7177834_7178047_-|cold-shock-domain-containing-protein
MSEKQSGTVKWFNESKGYGFIQREQGDDLFVHYSSINGDGFRTLHEGQKVDFLESRGPKGPQAEQVQVVE
>NZ_AP019860.1|WP_151970758.1|7178519_7178732_-|cold-shock-domain-containing-protein
MSDKQTGTVKWFNESKGYGFIQREQGDDLFVHYSSICGDGFKTLHEGQQVEFTESRGPKGPQAEQVQVTS
>NZ_AP019860.1|WP_151970759.1|7179070_7179739_+|hypothetical-protein
MKKLVWIFMILCCSCCRMPTFGNVVTDTPKMNWFTKPSSQFTVKHITNIIFDNDENNEIDLIGYLMVKNDNFRLLGMNEIGITLFDIYHEINKPLTTVKTFRDLEKYDVLQNIAADIRLLFLSPFDSANKIFTDDKKNTTYVKNNDDGSWIAWKISSTGVPQQITVGKCSDTIKEIRFQLGDGPFFEKAFISYPGITVELEILQVESRDIPDEKFVPGEVKT
>NZ_AP019860.1|WP_151970760.1|7179735_7180887_+|hypothetical-protein
MNRVVITGVGVINSIANDFSQLLPALRACKRNIGSVSLFPTTATYPVAEVKNFMSPSGYRTLDLAENACEEAIKDSGIDPYAFVFSTSTIGMPELEEDFLLRHEGGTQNFNYNDALSVGEFANKLARKYNIQGTTTSFSTACSSSANAIGYAFLQVQSGICDSALAGGADALCRLTYYGFQSLKVMSPVPCTPFDVNRQGMNLGEGAAFVVLETLENAQRRGAKIYAEVMGVGMSADGHHMSSPDPEGSGASLAMNRAMKNARITVQEISYVSAHGTGTILNDHTESIAINKVFQEHTRNIYVNSLKSYVGHTLGAAGAMAIAITICSMKHGYIPPTLGLRERDQACSLRMVPQEGVDVEVPYAMINAFAFGGNNTSLVLGKM
>NZ_AP019860.1|WP_151970761.1|7180886_7181912_+|beta-ketoacyl-synthase-chain-length-factor
MHHTKISIVNNEIIAPSGENYAAFTERFFAQSLQGSTERSLQFFNEEYAQHIKKIDNVDTSMIPSRLKRRMSFLTQMMISCATKCLQDCAYDRENLGVIIATGWGELETTEKLLMGIIEGGDVALSPTQFHNSVHNTAAGYLGIMLKVKGPTLTISQENHSLEAALAAGHLLINSQQTQHALVGGVDTYFRFSVLDPHNEKYPHTFGCGASSFLLSRDCDHGPYLEIISLADTLKTVAYASQLANKLRDVHIDMLWLSGVSTPQPFLQKLSTQVNVINNAKNPYYPTDSGMEITAILATLQRGELPDKIEGYNIQGSSGKIRHALYVKETQGIYKSFMIWV
>NZ_AP019860.1|WP_151970762.1|7181916_7182651_+|3-oxoacyl-ACP-reductase-FabG
MEEKKNALITGGSKGIGRAISIELAMSGYHVMVNYHSDDDAANTTKEMIEEKGGSATLLKFNVANHDEVQQHLLPIFEEQKQGIEVLVNNAGIIRDNSIVWMSKDNWDDVIRTNLDAFFYVSKIVSKRMVKQKYGRIISIASTSGQAGMRGQVNYSASKGGIIAATKSLAIELASRKITANVVAPGFIDTEMVQHVDQEKVLPHIPMKRIGTPEEVAAVVGFLASAKSSYITGQVIAVNGGMYM
>NZ_AP019860.1|WP_151970763.1|7182660_7184262_+|FAD-dependent-oxidoreductase
MRWTPYQQEKLNSDIDVIIVGSGISGLTAAGVLAKEGKKVVVLEKHYEIGGFTHTFKRRGYEWNTGLHYIGQVQNPESTMRQIFDYLSDFKLKWAHMGEVYDRLFFPDRSYCFYSDPQKFQNSLCVDFPEEQTAIETYIHDIVGGSACRSNFFVQKIIPGPLAKLTYPLLTRKFLQFSKNTTYEHLEKLTDNQELIAVLTGQWGNYGLPPKQSSFGIHALVASHYLDNGGSYPIGGSRRIAETIVENIENHGGQVFSKAGVESFLTEGKKVTGVQLENGDKIFAPLVISGIGAVNTFSKVPGLKFDLKEKLQGLTPSCGYMDLFIGLKGTPQSLGLPKNNYWIYPGYDHDDNVTKYLQDHKSEFPIVYISFPSAKDPEWTQRYPDKSTIEIITLASYDWFKKWEDAPWRKRGEDYMDFKEYFSKRLLEKLYEHFPHLRDKVDYYELSTPLSTKHFTSYSRGEMYGLNHTPQRFALKWLRPQTPIKNLFITGQDVVTNGVAGALFSGMLTTCAIMRKNMITHIQKEIAKENENE

Crispr_ID: NZ_AP019860_37

• CRISPR_ID: NZ_AP019860_37
• CRISPR_location: 7337393-7337507
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_37

Consensus_repeat	Method
CGATGGTGAGGGCACCAATCACAAAACGAA	CRISPRCasFinder

spacers of NZ_AP019860_37

>37.1|7337423|55|NZ_AP019860|CRISPRCasFinder
TCCCAACAACAAAAGTCCTACAACCACAACCATTCCACCGCTGAAAGCTACAAGG

CRISPR arrays and Neighbor proteins around NZ_AP019860_37

CRISPR arrays

The CRISPR arrays of NZ_AP019860_37

>merge|NZ_AP019860|37|7337393-7337507|CRISPRCasFinder
CGATGGTGAGGGCACCAATCACAAAACGAATCCCAACAACAAAAGTCCTACAACCACAACCATTCCACCGCTGAAAGCTACAAGGCGATGGTGAGGGCACCAATCGCAAAACGAA

>NZ_AP019860|37|31|7337393-7337507|CRISPRCasFinder
CGATGGTGAGGGCACCAATCACAAAACGAA	TCCCAACAACAAAAGTCCTACAACCACAACCATTCCACCGCTGAAAGCTACAAGG
CGATGGTGAGGGCACCAATCGCAAAACGAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970835.1|7339604_7340885_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970841.1|7349270_7350314_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970837.1|7343766_7344585_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|365877
NZ_AP019860.1|WP_151970830.1|7334126_7335089_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970840.1|7346045_7349162_+|efflux-RND-transporter-permease-subunit	unknown	unknown	gnl|CDD|223911
NZ_AP019860.1|WP_151970838.1|7344683_7345241_+|peptide-methionine-(S)-S-oxide-reductase	unknown	unknown	gnl|CDD|376578
NZ_AP019860.1|WP_151970826.1|7327781_7328615_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235628
NZ_AP019860.1|WP_151970823.1|7322872_7323478_-|hypothetical-protein	unknown	unknown	gnl|CDD|366133
NZ_AP019860.1|WP_151970842.1|7350345_7351851_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970832.1|7336601_7336988_+|hypothetical-protein	unknown	unknown	gnl|CDD|271360
NZ_AP019860.1|WP_151970827.1|7328660_7330787_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013573.1|7335261_7336605_+|amino-acid-permease	unknown	unknown	gnl|CDD|273332
NZ_AP019860.1|WP_151970825.1|7326028_7327462_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970833.1|7337527_7338535_-|DUF1573-domain-containing-protein	unknown	unknown	gnl|CDD|377880
NZ_AP019860.1|WP_151970834.1|7338570_7339596_-|zinc-binding-dehydrogenase	unknown	unknown	gnl|CDD|176251
NZ_AP019860.1|WP_151970828.1|7330800_7332711_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970829.1|7333375_7334110_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970839.1|7345241_7346036_+|glucosamine-6-phosphate-deaminase	unknown	unknown	gnl|CDD|238693
NZ_AP019860.1|WP_151970836.1|7341008_7343765_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013572.1|7323486_7325955_-|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|379056

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970840.1|7346045_7349162_+|efflux-RND-transporter-permease-subunit	gnl|CDD|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
NZ_AP019860.1|WP_151970837.1|7343766_7344585_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|365877	pfam00106, adh_short, short chain dehydrogenase. This family contains a wide variety of dehydrogenases.	2.8328e-65
NZ_AP019860.1|WP_151970830.1|7334126_7335089_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.00896e-104
NZ_AP019860.1|WP_151970836.1|7341008_7343765_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.52725e-18
NZ_AP019860.1|WP_151970823.1|7322872_7323478_-|hypothetical-protein	gnl|CDD|366133	pfam00498, FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.	7.40331e-05
NZ_AP019860.1|WP_151970826.1|7327781_7328615_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235628	PRK05855, PRK05855, SDR family oxidoreductase.	1.01943e-73
NZ_AP019860.1|WP_151970827.1|7328660_7330787_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.82176e-103
NZ_AP019860.1|WP_173013573.1|7335261_7336605_+|amino-acid-permease	gnl|CDD|273332	TIGR00911, High-affinity_methionine_permease, L-type amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	4.12359e-51
NZ_AP019860.1|WP_151970832.1|7336601_7336988_+|hypothetical-protein	gnl|CDD|271360	cd10325, SLC5sbd_vSGLT, Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain. vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	1.01611e-11
NZ_AP019860.1|WP_151970833.1|7337527_7338535_-|DUF1573-domain-containing-protein	gnl|CDD|377880	pfam07610, DUF1573, Protein of unknown function (DUF1573). These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.	2.26436e-18
NZ_AP019860.1|WP_151970834.1|7338570_7339596_-|zinc-binding-dehydrogenase	gnl|CDD|176251	cd08291, ETR_like_1, 2-enoyl thioester reductase (ETR) like proteins, child 1. 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the 2-enoyl thioester reductase (ETR) like proteins. ETR catalyzes the NADPH-dependent dependent conversion of trans-2-enoyl acyl carrier protein/coenzyme A (ACP/CoA) to acyl-(ACP/CoA) in fatty acid synthesis. 2-enoyl thioester reductase activity has been linked in Candida tropicalis as essential in maintaining mitiochondrial respiratory function. This ETR family is a part of the medium chain dehydrogenase/reductase family, but lack the zinc coordination sites characteristic of the alcohol dehydrogenases in this family. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. Candida tropicalis enoyl thioester reductase (Etr1p) catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis. Etr1p forms homodimers, with each subunit containing a nucleotide-binding Rossmann fold domain and a catalytic domain.	1.47138e-130
NZ_AP019860.1|WP_151970828.1|7330800_7332711_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.95041e-73
NZ_AP019860.1|WP_151970839.1|7345241_7346036_+|glucosamine-6-phosphate-deaminase	gnl|CDD|238693	cd01399, GlcN6P_deaminase, GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.	9.1331e-131
NZ_AP019860.1|WP_151970838.1|7344683_7345241_+|peptide-methionine-(S)-S-oxide-reductase	gnl|CDD|376578	pfam01625, PMSR, Peptide methionine sulfoxide reductase. This enzyme repairs damaged proteins. Methionine sulfoxide in proteins is reduced to methionine.	1.4834e-36
NZ_AP019860.1|WP_173013572.1|7323486_7325955_-|GAF-domain-containing-protein	gnl|CDD|379056	pfam13185, GAF_2, GAF domain.	3.38016e-06

Protein sequences

>NZ_AP019860.1|WP_151970832.1|7336601_7336988_+|hypothetical-protein
MTVDILIVIAYFAAVFFVALRTKDSGDISSEEFFVCSRSLRWPSIAISSIATNIQGYQFLGMMGSAYIYGLAQANLEINAVDGNWKGKIWLWCRIGRNTAANSTKNTTLCRYGNACFYLFWLSTYRRM
>NZ_AP019860.1|WP_173013573.1|7335261_7336605_+|amino-acid-permease
MKKQFDQVMGVCSASSMVVGIIIGTGIFLTAGQIATYIESPTWILIAWITGGAIATTGAITMAQLSSLIPRVGGLYIYIREAFGELMAFWYGCILFLVLQCGSIAAVAMGFAYYFGNIFPSFFGADVVWLHFYDFSLTAGQVTAIFAVLVLTYINYIGARLGSIVQVLLTVLSIVTILVFLAIAFTVPKPQTLTLSLVNAPDFSKFSLAMIPILWTFSGWYNLNFAAEEVQNTSRTITISLLSGMAVVTFLYLLVNVVYLTTLPIQQIQKETQIAYTVMNVLIADGGIFISVAIVISALGTLNGLIFASPRAYFAMAKDGLFPILPAKLHPKHNTPHNFITIQGLWAICLIILGQGSYNALFTYVMFTGLLFTSLAGIAVIVIRKKQPIALAWAYPWIPVFFTLSSIGLAVNTCYYSFMESIVGLLIVLLTFPLYFLIKNKPHGSSV
>NZ_AP019860.1|WP_151970830.1|7334126_7335089_-|protein-kinase
MDGKFKFEQLGPYKVIEKIGSGGMGIVYRVEHAETQKEFAVKVLNIHQKLDRSAIERFIREINVTSRLQHKNIIKLHDKGVHDGRVPYFVMDYIDGVTLTEFLNNSPSPNAIARIFVHIASAVHYAHQQEIIHRDLKPANIMMDKRGKPIIMDFGLAKSSISETLTATGVVMGSMPYMPPEQADGQRHEIDEVSDVYSLGAILYECLALRPPFVGNSSPEIIAKIFNQTPTPPHKINKKVPKKLSAICLKAMAKNKQDRYQNVEAFSQDIYNFLTNKNTSASLVSTSTVQPFVLWIKKNRKAFIINMIVIIVIIVFMMLR
>NZ_AP019860.1|WP_151970829.1|7333375_7334110_-|hypothetical-protein
MPKLNQILAIEKGIKSRVTGAVTKLRKMILKPALLNGFSKTYVKKDEDGDNFPPENNKVQLVASEAIADLQKHLTELLDVTLTKDVANCSAVADVVVEGNVIMEKVPVTYLLFLEKELANLQSFVAQIPVLGSEDDWFFDENSNLYKTQPTLTSKTKKVQKPIVLYDATKEHPAQTQLITEDIVVGHWSTVKQSGALPMPRKKQILEKIEKLSNAVKFAREEANSTEAKQLYIANKIFQFILDK
>NZ_AP019860.1|WP_151970828.1|7330800_7332711_+|protein-kinase
MTMQLLHNRYKFEKVLGQGGMGKVYLMHDTNDQKLVAVKECVTKNDFELIARVKREYYFMTQIEHPFIVQATDLFELQGKYFIVMEYVQGITLDEFIKTRKNRIDFLQQLKMSRDICKAITVLHNNGIIHRDLKPSNIVIQENLQPKILDLGIAKSTNEELTEITKTGHMVGTPSYMSPEQIDSTKNTLQNTDVFSLATIFYQFFSWEQHSPFYADGLIQTIDKVHNHKLPPVITKLSNVEAKSIVLSNLLVKALKKDPQKRITSVEEMLKIFDNIIGENFEAIDEKMKKTKNYERFFGEKTSSVAPKNSKKLYIQATFLAIFMVIVLLTASNFLWRTNENTEQQMRDKIASLEKTLRATKGKTSKLLEQVKTLRIHNKSLESNKNDHLQSVIDNLLNPLGDYTKGRQTYLVLSQLKILLFFREHWKPQHLNKMMLALRYVLDQSYKEQELYLKVDLAKTAWRVSGEAISYAAKGEKMYFLECFLEVCFCYTPLHAAPFSVKTIKKHTELVRKSKLNGFLSIRVSKDTPKEALEKLPEISHKYYLLADYYDEQQRTSQNRKMSIRCLEKALQLNPLQPKYIQDMARFYNKLFKLSAFMEQEYYEKSKKLQSDGKKICKVYTRLLPIFQKTLERLND
>NZ_AP019860.1|WP_151970827.1|7328660_7330787_+|protein-kinase
MTPQDYFNICDIAHKSGFITKEQQQEILQVVQKFLQEKKQVPIVAILKKYGLHDDQFRAIQQQKERLFRQTVANQQIEQQRQQEKELELSFSQTISVGASKKIGKYDIVKLLGSGAMGSVYLAKDPNGKKFALKTMLPAVAESKVGLKRFQQEVNAMKMLRHPNIIKIFEIGQQDDTHYFTMEYIEGKPLSEYVQDKMSAKKIAYVMEKVARALDYAHSKDIIHRDIKPANIMISKDGEPVIMDFGLARQSQSDNRLTKTGAMLGTLAYMPPEQVQGNKREIDHQTDIYALGASMYELMTRQLPFSGQHLVVLRKIVQDDPTPPRELNNLIPEALERICLKAMAKKKEFRFSSAMEMAEDLQRFQGGETIEARLDRASISKKGKVQILRIAVAVACIGVIILLGSLLTSTMRDDTALKTVSDQLATAKQNLEDQKKYYSDLLDKKNNQIEELTLQNKNYMSTIVNKLTVVLETHMKNDNAGKTLSLLKTLLLYKEHWKPQHIGRISLALDYVRRNSYEEQELYLKVDMVKTAWRISGEAIAYADKDQKMYFMECFLEICCNYVPLSKANFSTEVFKKYDALARRSKLYNFKNIGVPKNASKDTLEKLPEISHKYYLLSDYYDEKERTTEDRKMSLQYLEKALQLNSNQPAYIQEMSKFYKKLYKQSVFTNKEYEKKSDQLRREAIRICKVYVKLLPIFQKTLDRLQKR
>NZ_AP019860.1|WP_151970826.1|7327781_7328615_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKLKDKIAIITGAASGIGYAVAKEMAKEGATIIVADINFEQAQKAAQNINEYGKAFAHSVDVRDAEAVKKLVDDVAEQHGRIDYMFNNAGIAIMGEMMEMSLEQWNRLFDINVRGVIYGTHAACNVMKKQGFGHIVNTASLAGIIPSPNLGAYSGTKHAVLGICKSLRIEAREFGIKVSAICPGVIDTPMVTDSEMINEEQLAVSREEIRENIQLTPYPVEKAARVIVKGVKKNKGIILITGHAHILSRLYRFFPGLSELIGRSYYKREKNIFAKKK
>NZ_AP019860.1|WP_151970825.1|7326028_7327462_-|hypothetical-protein
MHKIIFILVLIVICVEIFLEDDKPMQRLFREINTTDRKVSMAGLEKLNFLSKSEKKDFVSVLLYEAKKDEHHFTRMGFLNLLRRYKLVNANDHQFVMPILSFSTGKAQAKLVSKILKLMMSKKTGEVIVEAYKTDAITFPEAVKFLGENEEALTALADFERTKLSPRSINEMAAAAIDNEPILFEALLLMYNSNAAERKQISTFFLHALENNRLDEKQALRVLKILHRNISEEQIPQFLAIIRKNLQDKNLILATVRACAMLQSSTDDIAILLKKLMQDKQVTDSFLRTEIEINILTVLLRVQKYQSFAVEHLIKNMRYDRQYVKLLVEQTSENPRVDDVCFRWLEADKENVPSLITKFLAEKQHERAFLAFVAIADELVFVENKYYQCRRVLSALSKYKDKKPYVTKKFMQYLEEVSIRPIIKCDIISYIRDMGVEKVAIPTLVKLQAQSVDSRVLVQAEMTLRQLGYNTGSDDLK
>NZ_AP019860.1|WP_173013572.1|7323486_7325955_-|GAF-domain-containing-protein
MMDLSLQSKLFRKMQNVKQLLLSLSSHEVSSLLLSDFVKRYVDTHDDYVGPLYKIDFQLPTDKWAGIAQSQYALTYMKIILSVEQDIQRNCPLGAVMRDTLQKIELAFPDLYNMSIWSCDVQNVADFTCRSAIHNADNSVNVSFPFRLFVLTDMLRSAKHVAWFYRHDTIKCCTPLVHQQQIVGAVYCEIDKKEAPYFMCFLDIIASLLGHLLSLTTTSTDLVVVEKAAIEDRFEEYQRKTMGKPSLEEEQKMIDIAPPQMQEEVKKVSRETKSIVIKPTEAKPIETKVAEPALPSRTIIKRILQTQEAVLTEDAKGDYGDMAVSIVNQNIESAISAPIIKDGEVKGVIHLEEIRVNRGFRAKDLTLVNIVATKLAKFLDQVQQRQGEYFSQKKREEPQEQLEQSPQKPQVSLQQLREMASYVLQKIENKEFSSQQLDEILGDMNTQDCQNSYWSAIWKVSFFLVRFSQNPQHIVDDFIRDHRKVSPPLFEEFLGDEAMRPGPIERLVAQSAKLKKWIQATLGLKFIAIANIMDTLIEFFTSMIKNFFRSWKFAKSVQRHMERERLGNMAPAMANDWQRNRRLLSRYLRIAGFSPQNSQATFALELALDIRHNLDESIRDLSLLTATQRSSVAKKSLFEFIGGFIPNPFEVLWAWKDIFIVVFFMKYNREEVEHMYWQMVDSGRQIVSFLNEEQTKPVAVELQSYEYELQWRMAPQKTYSDLDECIEASRYHLQRLLQSIASSQLITPKSWTLLDLIREMKLNRSSNQVNPLCDVELEKRILCVLKPWMKTTDLQQLQLQLQDNLLFRERCKNVQQSASAFL
>NZ_AP019860.1|WP_151970823.1|7322872_7323478_-|hypothetical-protein
MMCAQLIIMDGPDSGRHFELEVVNNIGTNEICNIRLMSPNIDYVVSIKKKSNWFMISCPGASGGKTLVNGQPVYRERRLKHGDMITLSDTMLLFGEELSSSALMNTHNASEPMITSTQSLHDLKSLKEELQNLPMSYVGIVQQIEEIIFRHLKQEPVNVQAALQEVIEVLIRNNIGDRGTIFLKEGSKLWPIASASYKKFR
>NZ_AP019860.1|WP_151970833.1|7337527_7338535_-|DUF1573-domain-containing-protein
MNRLLITLLFFPLCVFADGIVDITPKILHLKTIRDTDEVTGTFTLRNVSGKMMNITQVKTFCGCTYIEPNTRNVSPGKSTKITVKYSPKGKQGPQETEVHVYTNLQSNPLVLRFDAHVLRNHHLSDDILSFGEFRRGKQVEKQIWLSPLNYPNFQVKNVTLKINEANMRNRFTVSSGYGTYDKLYPGKRRAFWVKVSVSKEVSFGKATGNLVFTTDIPQKEVISLPFFAKIAGDISLSREHIAMGMLRKGKKASRNLMVYPTEENERVVVTSVKCSLPFISAKIFPIIENQYYEIKFFSKVSGREKRGEFRGTVTIQTSNKNQAVITLPIQGFIR
>NZ_AP019860.1|WP_151970834.1|7338570_7339596_-|zinc-binding-dehydrogenase
MKKIEEIPQKAQAVVLKSYNEDQADVEVQEVEVPLPKDGEVLVKMIASPINPSDLMFTKGLYGVKKELPVVPGFEGCGIVVAAGGGFTSKFLLGKRVACGATETGGGTWANYMLTGSDYCMPLKKFVADHEAAMMIVNPMTAWGMVDEALAGRHKAIVQTAAASALGKMVIRLGKRFSIPVINVVRREEQVKLLQEKEQAEYVVNSSRDDFDEALSELCHKLHATIALEAVSGELSAQIAAAMPRKSELLVYGALSREAVNIHPGDLIFQEKTVRGFWLSKWLKEKSLLQKISIAGKVQKLLSSDLSTHIQQKSPLDDIQNALKTYEDNMTAGKVLLQCSP
>NZ_AP019860.1|WP_151970835.1|7339604_7340885_-|hypothetical-protein
MKYKVEHCIDTMHYQSTEFVQFVQQDVRQYRIQLEEKILDDLINLKDMVSQSQLYYEDPDFKISFDSIATTLDYIHEAIGKLVESRMIPMLRTEFSTKVNAYGKKIAENDLKEAVCSIVDSFAQQMIEKLDHFIQQIDHSKEQTKNRFENFEHELKIYNKLNKDILEGQFIEEVSLLHALSSMLQELAMALDIFKQGIENLKNTLEKYGEHVYTTFIKEVGKRHTSFMSFFGKNKKEENSESKGQTPVSKRAKRKISAIKNIDTMPMPDFTSKKGKNSAQIAVDFPYNNSKIIEVIMQFTVGKYTAQKVKLELETIFQKKAIFILSAAAGVDLEPFKKDVVHDVISTMQLVVKRRRVQVQVQEGLQVHYLSKIVPKIPFADGNLNFVSYEKNGNLVLEYVDLAEETEKLDESKLQKTLTECFAIFE
>NZ_AP019860.1|WP_151970836.1|7341008_7343765_+|protein-kinase
MPVNNRFLASIQNMDTRSEVAKHSFATTEIIVVDISDLLWTAKEKNTAQSKISPVYQCKVVGEIVVANRQMILPDDFLVLTPKISSTMKSLEVAPPAKQVLKKQVSNAIWIGANVENLSCEKAIITDAKNFVYDEGLEERGPLSKNDFIQPNIEKPKKLSQRQIIHIGEKPAKNNLWKPQEKQVDLFNNEFVTPPSQNVPHSQDSKIHNSQPPKVPVNNAHVLHPHLRQTSRTSMNSSIAYQYRFEGLYARNRLGNLYFCQNRNTNDRHLALILHRQYSFASVSTLQSLAKLRHRYILPVKDIGLHKGHTVVFMAVDRITPLRMYIKENDLSIQQKLYLVQALITAIEYAHSYNIRHGNLSMSNIFMDPQGCPKIMGFAVRKTKPTHIPANGLKQLSSALPNRLRISKKDKRNDLVAIGYILFELLTGKAALRRDTMNKLRRRSDLQEVSFPKHLQKTIPRQLQFICLKSVDTRADYGYETLHDLKEEINSLLQNDHHDEKWGFYSYRLKTWWGKHRDRANVYFIGIAIFMSLWLVPSNLKVPSMFDPNAKAEEQIIAELIEDLQSNDKVTCVLAIKKAAELGESAKNVLPLLQRLTWRDEAVISENAHDAIAAIRKKINGGELQNLDSDEILAMLQNRFSDKRRQGLDAVEKLEKVENPIIESLLSIASFDASSHIRDKAKSILEKIKLTENNFVTFTKLLRNRTTHVKRLVLKKVLASSAVDKENIIRLSIEFLDDYNSYNRGLAISFLKKEINNEEKWIRALVPKLRKANIEMRQDIYEILGRITPIHPKNSAYFVELLREKNSYVNTYAQQAFAQIDLRYAQTTQYLLEDAYNRAIKTDKEWILRGLAENDYKCPTIIPLLEKALRDPNVSVRKWGAICAGRMRRMAVPLIPELEALLKGRAGKEAQKALDKIR
>NZ_AP019860.1|WP_151970837.1|7343766_7344585_+|SDR-family-NAD(P)-dependent-oxidoreductase
MKYFYDKIVVVTGAGSGIGKAVCQILGKETSAIVIAIDINYDACKKTIQEINQNLQQAFACDVSDFDHFSQVIEKIYARFLRIDILFNNAGIGIAGEIKSLNIDDWYRIIDTNIKGVIHGTHLVYQKMLQQKQGHIINIACLAGLIPFPDVTVYSMSKHAIVGFSCALAFEAAKYGIRVTMVCPSAVDTEIVHNSKYVGMSEEFVEQMWRKIPKMSPDRFVFLMLRKVARGKKVILLPFSSRFVWWLYRLCPSVVLRCLAIGAKWAKSKEKT
>NZ_AP019860.1|WP_151970838.1|7344683_7345241_+|peptide-methionine-(S)-S-oxide-reductase
MPGVVSTRVGYAGGTIDDPTYRNMGDHIETLEVDYDSQVVSFADLLEVFWKSRRHDRPPYSRQYKSAIFPHTQEQSHIVQETQKAYKKKYQVSYVEVIEKFTFYMAEDYHQKYWLQHTPFLLMLFYKVYKDDLMPTLFRSTVAARVNGYIRGYGKFSQIQAEFPKFNWPQEKQQEILAFLEKRDL
>NZ_AP019860.1|WP_151970839.1|7345241_7346036_+|glucosamine-6-phosphate-deaminase
MEVIILKEPQQIAKKCADIFQETICQKHNAVLGLATGSTPILLYRELVDRYQKQLLSFENVVTFNLDEYVGLAPEHPQSYSYFMQQHLFKYINISSKNTHLPNGIAQNPIRESREYEEKIREYGIDLQLLGLGSNGHIGFNEPTSSLGSQTRIKTLAQQTIEDNSRFFSADEFQPTLAITMGIGTIMFAKRVVLLAIGEKKARAIQQAIEGPISAWCPASALQMHPHTTFIIDEEAAQFLQMKDYYHWVYKQQQQLLQKLHNEK
>NZ_AP019860.1|WP_151970840.1|7346045_7349162_+|efflux-RND-transporter-permease-subunit
MSERRSFLSWSIFRPVTVTMFFVAFSVAGVIAYKSIPLQMMPDGITWPVLTISVSYDNANPSDVEKKITRPIEEMAGTIQGVKKIRSRSSSSGSRVRLFFDSSADLNVMYNQLQDRMERLMVDFPEDVTRYRIRKFNFQDFPIQYLGISLKNEDKSLSPQESLKQLVDYSALFERTVLMRLEQEDGIANVELHGTYSKKIYIDLIPDKVAAYHVNVFQLVQRLRNANLNLTQGKLLDDRGTFLVRSLGKFTSLNDIRDFPVKEGIKLKDIADIFLASSLRSFRVRINTLPAMFCEISKESGANTVEVCRKVKKIIASYEQDPRFEKFAFTFLHSEGDAIEEALTNLQETLLWGAFFAVLVLFFFLRSVRMTFVITFSIPVSLMMALVVVHAYGGTLNLISLMGFTLGVGMLLDNAVVVVENIYRHLENGLSLLDAAVKGVNEVGLAILLATSTTLVVFIPSMVMTDGSDSIFMIEMGGAVCYSLVASLIVALVFIPPAVYTMEKRKKTVKRFFIFEKIVYKSSRAYYHTLSWVMAHRFETLCFILIPLAYSTWHISEKIGVTNQQQGSQREMRVHFSFTDSQDINKNSELLLKIEKAILAKKNELEIINFLSFSRDDSARIRFWFTKGDDIKRTTNEIAQDIQKLIPPLPGVAVRGNWRKSGGGGGGDQEEGDVPIVLRGENPETLRDIGREVEKLLVNIPELLDVGVEESEQSEEIILYLNRDRTERYNVSPRQTATTVSYALRGSIISQFQIDDNEIPIEIQFSQSLVANADMLRDVKVYNRDQEEVALGTLGKILYEKGFATIRRTDRKTTYTINATANKSDLGILGEKIDKALKTLKLPRGYTINKEGRFIELEENQDSFMKSMGLAVVLVFLLMGFLFESFVLPFSIILSIPFAFIGVYWTLYLTSTPISMMVYLGNIILAGVVVNNGIVLVDYINRLRNEGMERSQAILEASFARFRPIMMTSLTTLFGLLPMAVGTSEFAGTPYYPLGRTVIGGLTMSTLLTLLIVPIFYVFFDDLRNTFLRLITGVFIKK
>NZ_AP019860.1|WP_151970841.1|7349270_7350314_+|hypothetical-protein
MFSRKFIFLCTSFIFLTSCSLLSTIFKPDLEEEKRDRFEVATGHKLMSLYEKQDKLGYVFDQGTFIKNIWGGKKTESHTGQSITLTYTRKDFDKLKLFLGDNFNVGPSLESVHHVNVDLEDIRKYELVDIQPLVEYMGKNSLGLIRKDFVVSMIKVSRFTIRAYEKVMGQFGAEYRPFSMLKVGGKTGVSVHRKDEQIGYNVFIGYKLYNGSEWWDNNFESLPKVGVIVDQPKTESTIDRVRARVKGKIAQYNSLPEDDRNSLRMYIMTRSEYEDAWTLQSKAIVDTEGYFEGIVKLGTLESGNGHRYSIATFVTYFDINRDVNSQIPFLPFNKGKYVIRVTRKDVF
>NZ_AP019860.1|WP_151970842.1|7350345_7351851_+|hypothetical-protein
MMFHTIVTHEHPDLDAMLCCYLLKKYGSNRYQGLQEAKILFCPAGRLPGGKTPDELEAEGILAVDIGGGRLDTHPSGHSISEEKKTLSAANLVAKDLGVHDEERLESLLEFARIHDSLGKSLRSRNPIDHLMALPNLIRGASFHFGTSFENITTFFFKIFEAIEHAHSATREDFFDNDSCVLSVHENTIFLPKKAHLRTLFACYLFKRYGEKEYNYSFDKPKDGTQQWHTIAEVISYCQLQEKQSLGKIIDFVEQIKPQRFLLSSKFPMDETVSLINIIRGFYAQHSDDLAQCIDEIFLLLDYIVAHEENWYNAIAEYQEKRQLFTLRDAKVVVVSAKIGAVAKVARWLDKADLTVFHDEDKQHISVSVNRTGKLRKLRLGRLASKIRMAEININKEFADVRTDNLQAIGEIAGWFLHQSEKLLIHGSPKAHREPSQIPFAVTTELILSEIEFEKKLPDMFCPKNKCLHKRCCFYTLRLPNCFHHRRLCEKKQNFNGKSKS

Crispr_ID: NZ_AP019860_38

• CRISPR_ID: NZ_AP019860_38
• CRISPR_location: 7444535-7444670
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_38

Consensus_repeat	Method
AACGCTTGATAAGCGTTAGGTCGTAGGTTCAAATCCTACAGGCTCCA	CRISPRCasFinder

spacers of NZ_AP019860_38

>38.1|7444582|42|NZ_AP019860|CRISPRCasFinder
GTTTAAAACATATAGGAGCCTTAGCTCAGCCCGGTTAGAGTG

CRISPR arrays and Neighbor proteins around NZ_AP019860_38

CRISPR arrays

The CRISPR arrays of NZ_AP019860_38

>merge|NZ_AP019860|38|7444535-7444670|CRISPRCasFinder
AACGCTTGATAAGCGTTAGGTCGTAGGTTCAAATCCTACAGGCTCCAGTTTAAAACATATAGGAGCCTTAGCTCAGCCCGGTTAGAGTGAACGCCTGATAAGCGTTAGGTCGTAGGTTCAAATCCTACAGGCTCCA

>NZ_AP019860|38|32|7444535-7444670|CRISPRCasFinder
AACGCTTGATAAGCGTTAGGTCGTAGGTTCAAATCCTACAGGCTCCA	GTTTAAAACATATAGGAGCCTTAGCTCAGCCCGGTTAGAGTG
AACGCCTGATAAGCGTTAGGTCGTAGGTTCAAATCCTACAGGCTCCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151970905.1|7441817_7442069_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970909.1|7444703_7445933_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970906.1|7442596_7443337_+|metallophosphoesterase	unknown	unknown	gnl|CDD|365906
NZ_AP019860.1|WP_151970915.1|7454493_7455624_+|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293786
NZ_AP019860.1|WP_151970901.1|7434824_7435385_+|DUF309-domain-containing-protein	unknown	unknown	gnl|CDD|377120
NZ_AP019860.1|WP_151970910.1|7446582_7448817_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|238697
NZ_AP019860.1|WP_173013580.1|7452121_7454095_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151970903.1|7438274_7440110_+|hypothetical-protein	unknown	unknown	gnl|CDD|238250
NZ_AP019860.1|WP_151970907.1|7443491_7443671_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970912.1|7450709_7451108_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970908.1|7443788_7444325_+|DUF309-domain-containing-protein	unknown	unknown	gnl|CDD|377120
NZ_AP019860.1|WP_151970918.1|7457571_7458285_+|hypothetical-protein	unknown	unknown	gnl|CDD|239946
NZ_AP019860.1|WP_151970900.1|7431125_7434716_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
NZ_AP019860.1|WP_151970902.1|7435531_7438261_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
NZ_AP019860.1|WP_151970899.1|7430628_7430808_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970917.1|7457117_7457504_+|response-regulator	unknown	unknown	gnl|CDD|381085
NZ_AP019860.1|WP_151970913.1|7451438_7452104_+|metallophosphoesterase	unknown	unknown	gnl|CDD|277325
NZ_AP019860.1|WP_151970904.1|7440249_7441062_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151970916.1|7455747_7456740_-|hypothetical-protein	unknown	unknown	gnl|CDD|274076
NZ_AP019860.1|WP_151970911.1|7448841_7450446_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151970906.1|7442596_7443337_+|metallophosphoesterase	gnl|CDD|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	2.31999e-05
NZ_AP019860.1|WP_151970915.1|7454493_7455624_+|ankyrin-repeat-domain-containing-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	1.53894e-21
NZ_AP019860.1|WP_151970901.1|7434824_7435385_+|DUF309-domain-containing-protein	gnl|CDD|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	5.91324e-15
NZ_AP019860.1|WP_151970910.1|7446582_7448817_+|tetratricopeptide-repeat-protein	gnl|CDD|238697	cd01406, SIR2-like, Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.	3.05393e-19
NZ_AP019860.1|WP_173013580.1|7452121_7454095_-|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.16972e-100
NZ_AP019860.1|WP_151970903.1|7438274_7440110_+|hypothetical-protein	gnl|CDD|238250	cd00443, ADA_AMPD, Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.	1.28947e-27
NZ_AP019860.1|WP_151970908.1|7443788_7444325_+|DUF309-domain-containing-protein	gnl|CDD|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	7.3439e-12
NZ_AP019860.1|WP_151970900.1|7431125_7434716_+|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	5.04725e-16
NZ_AP019860.1|WP_151970902.1|7435531_7438261_+|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	2.06522e-11
NZ_AP019860.1|WP_151970913.1|7451438_7452104_+|metallophosphoesterase	gnl|CDD|277325	cd07379, MPP_239FB, Homo sapiens 239FB and related proteins, metallophosphatase domain. 239FB (Fetal brain protein 239) is thought to play a role in central nervous system development, but its specific role in unknown. 239FB is expressed predominantly in human fetal brain from a gene located in the chromosome 11p13 region associated with the mental retardation component of the WAGR (Wilms tumor, Aniridia, Genitourinary anomalies, Mental retardation) syndrome. Orthologous brp-like (brain protein 239-like) proteins have been identified in the invertebrate amphioxus group and in vertebrates. 239FB belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.38419e-37
NZ_AP019860.1|WP_151970917.1|7457117_7457504_+|response-regulator	gnl|CDD|381085	cd00156, REC, phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs). Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.	9.30615e-12
NZ_AP019860.1|WP_151970916.1|7455747_7456740_-|hypothetical-protein	gnl|CDD|274076	TIGR02307, RNA-editing_ligase_2_mitochondrial, RNA ligase, Rnl2 family. Members of this family ligate (seal breaks in) RNA. Members so far include phage proteins that can counteract a host defense of cleavage of specific tRNA molecules, trypanosome ligases involved in RNA editing, but no prokaryotic host proteins . [Mobile and extrachromosomal element functions, Prophage functions, Transcription, RNA processing].	1.10887e-39
NZ_AP019860.1|WP_151970918.1|7457571_7458285_+|hypothetical-protein	gnl|CDD|239946	cd04502, SGNH_hydrolase_like_7, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid.	7.61219e-65

Protein sequences

>NZ_AP019860.1|WP_151970908.1|7443788_7444325_+|DUF309-domain-containing-protein
MSNLSICSKMPRLIPERPFSPYRYVNGLNPHPIKDPKGHSYGSQEPTYSLEYLDPDNWQQNKDYLYGIDLYHHFYFWESHEAWEGLWNAYGRETIPGKFMQGLIQNAAAQIKLHKKQLTHKKLFRISLLMCGETRNPFILTLLSGLLPNVNASISSAKNVQAPWNIRSLGIQSSIMML
>NZ_AP019860.1|WP_151970907.1|7443491_7443671_+|hypothetical-protein
MEDFKQIKQAFTKIKEYQQMFHQLPREKRHAMSHQEIADYLDTNQEIVRLLFRGGHIKK
>NZ_AP019860.1|WP_151970906.1|7442596_7443337_+|metallophosphoesterase
MNFTIKNTYTIDVCAPLSRQGKPASYQATVTIIEAEGDVQCPIILTSDLHNNTDLVLNHLEEVLPKAKDWTFISAGDMAGDGKKGGDGDAIPHLQWAKGLFRRVYFVQGNHDFNSPHAQKMKNSDGTLCHLSRRRQNIAELGWIAGMDGIISSKKKLHRTPKKEYFREIQNLAKKGLQWLVTHEVPCIPSISKQKKGYAQLTEIVTNSNIQCHVFGHCYFSEWYGKIKSSSFFGVDGRVILLKPRE
>NZ_AP019860.1|WP_151970905.1|7441817_7442069_+|hypothetical-protein
MSKSLQDLLIDLDRAIHKLSFKKLAEHYSCPWNYQQKEIQNIWQQIIHPCHEEELKKLVERDDINIKAKRVFTHALDECGKKR
>NZ_AP019860.1|WP_151970904.1|7440249_7441062_+|hypothetical-protein
MRHRQVKHKSKKTPKVKAGKVQRKNFRDVRNSPDKQFFIHVESPRLGYEHFVSQQDIKTFLNILPQKETIMSGLQSICLVDHEHCDGWYEDGNIHICAWEQEMHRVFDALHYDEHKEILAELSIPCEKISGELMHQFDIVDVTDLYEGEIPYHMEKVLCDDWREEFTFDLIHASDFQWQINRGEIELYTAMISEQTIDIYSVDYLCKFTRETIRDYQLLHILLHELGHHQDCTTTPGKGYLIRGEEYAEIYARKYEKSIWDTYFAVFYPN
>NZ_AP019860.1|WP_151970903.1|7438274_7440110_+|hypothetical-protein
MESLFRAITLILLSIICFTSVQVYWEIELPQKNSFDSQKNFWDANMGSPAARFELAKRTEPELIAFVRRMPKGADLHNHASGASFCEYVLQAARDNQLKYNKDTQKFVAYLKIRYHNESKKFVSNQIEKYDSIASLEVENSHFLPTKNNAVSDSIIFSYHQQTKTFVSQTIQNPQNIHHITLKDQSNSYEFAVTQDIITIDHLQRDSSLLSSFLDRYSMRGWSEGKNNGHDHFFKIFEYLDSSQQSKKDVLVEMIPRNRYQNVQYLEVMMRSFPKKIEKGIAKKFAIDFDIHNLDKMFTHVQDIAKDYNMLEEIREYINRIDTDVQTYLRLRYPPSDNRGDIVIRYMHQLKRFKSPKDVFITAFIAAKASKLDKRVAGVNIVAPEDSPAAIVNFSHHMKILGYLWEKMEKPRFSLHAGELSLRESPVEPMRHHISESIHIGHALRIGHGVSIAWENNVVGLLQHMKERRILVEICLSSNESILGIKGDRHPFMMYKRAGIPMAISTDDEGISRSNLTMEFIKAIRRYDLNYYDVLTLVRNSLEYSFLEGESLFITGDYSKINPQFSDVRSKNWQANDQQQQIMEKNAKLRQQVKLERKIVAFEKFLLSGFK
>NZ_AP019860.1|WP_151970902.1|7435531_7438261_+|HEAT-repeat-domain-containing-protein
MKKLFMVMAFSCLVIAQNISDKRIVELLGELPTAPVMEKSYIARVLGKSKDVKVVPALIKLLSDDNMMVRYSAICALGELNAQATITNIVPFLHKSQPKYLRQAAMKAVGELKAVQAIPALLKRVPIEDRGSLYGLVKSPELDALCKIGLAFPSQMVDQLVTTIQTYKPKQDLQTIDDFVLLIFFHYLPHQHKLPLVEKTQQRIREILLPQLFTCCRDTRSYVKKRALKILRRLAKLPQMAIPIFEELTNSPVAEVREQAIYALVEMGQENAYSLLWPLLNAKNNTIKNNALEVLCHIRYENATSFLLGVVQKSPPEIRVRAIGALLKIDYPKMQHFITKELIPLIPHPNRNIGYYISDVLYENNQKLSDDIIVAMMKSRNDNVRDDAFAVITSRNYRVVDARIIPELLTEIHKGKRHNFDALFTLMAMKEAATPAIPALKKMFFESYQKEDSYCDKICEVFYSIGQNAQPVIKELLLHKSATVRGYAIPADYITFTKEQCKWVVPLLLEAYQKESTHITGILDALEGIDTPEEFGIIEIIVTRLRDKSKYNNWDTVGNVVGIYLSHFGAASIPHLQKILQNETQDLELLVLALKALRDIFNYKVEENSSDKFAIMSTLWKVMENPNPKVKLAAIEAIAAALPFSKKSYLLELISLVTNDSGVAIQNAAIQAIAKDPQAVTAIPFLLQMLQQKEHQKAIVETLASLQEQAQQALPALNELFAATTEPKDKKLMEEAILRIAKPPLAISDDPTEFLTLLQDLNPQSENSRVINGFVAKGHQVIPVLIAILEQEQSLATRYYAAKILSQIGSETKLALSILLATLAEECNKSYIHPKSLTRGACGTAMFKVYNEYHFGKSLQESLIQCLGNLGQDAMAALPMITKMKTDENQKVRQAAIQAIQQITLENKK
>NZ_AP019860.1|WP_151970901.1|7434824_7435385_+|DUF309-domain-containing-protein
MSNLPICSNMPRLIPERPFPPYRYVNGLNPHPIKDPRGHSYGSQEPMYSQEYLDPDNWQQNKDYLYGIDLYHHGYFWESHEAWEGLWNAYGRETIPGKFMQGLIQNAAAQIKLHKKQLSGVCSLSKKSWANLTVVSDCLQRNDRNNFMGISITELFSEMKRCYKPFWNGTPNFSNVVIPILRIHNP
>NZ_AP019860.1|WP_151970900.1|7431125_7434716_+|tetratricopeptide-repeat-protein
MQEQNLKSLMEQTIQICEKGHYSQLACVVEKINEIIPSMYSKDHPDYATTLNNLAALYQKMGKYEKAEPLYLEALQIREKSLDKDHPDYATTLNDLAILYREMGKYGKAKPLYLKAIQIREKALGKDHPDYVTTLHKFAQFHYSMGEYEKANTLYLEAIQIHKKALGKDHLDYATALDNLGVLYKRMGKYEKAEPLHLEAIQIREKALGKDHPDYATTLNNFANLYKEMGKYTEAEPLYFESMQIREKALGKDHPDYATTLNDLGEQYNAMGECEKAETLCIKAIQLREKALGKDHPDYAISLYNLAQSYYVRRDYEKAKPLYLEAIKIEEKVLGKDHPDYAISLNDLAGLYQEIGEYEKVEPLYLEVMQIYKKTIGEDHLYYAICLHNLAALYQEIAEYDKAEPLHLEAVQIYEKSLGKSHPDYATNILGLAELYKSMRKYEKAEPLYLEAVQLREKTLGKDHLDYAMGVNNFAGLYQQMGDYKKAEPLYLEAIQICGKTIGKDHHYYATSVSNLAALHQEMGEYEKAESLYLEVMQIFEKTLGKNHPYYANNLNSLAGLYQQMEEYERAEPLYLEALQIIEQTLGKEYVDYVTSLINLAAFYKLIGEYKKAEPLYLEAMQIFAKTLGKNLDYATSVNNLAGLYQKMGEHGKAEPLYLESIQICENNLGKDHHDYATSVSNLAVLYQEIKEYGKAEPLYLEAIQIYKKNLGSDDHYYANNINCLAGLYLEIGEHEKAEPLYLEVIQVFEKSLGKDHPDYVAGLINLAELYQQMKEYGKAESLHLEALQLYEKTLGKDHPIYAKSLNNLAVLYLEMGVHGKVEPLYLEAMQILEKALGKDHPGYANSLINLAAWYKETGEYGEAEPLYLKGMQIYEKAFGKDHPYYIDALRNLALLYKSIGEYGKAEPLYLEVMQIFERIIGKDHPHYADNLHNLAVLYESMREYEKAEPLYLESIQICEKTLGKDHPYYANNLNSLACLYESISEYEKSEPLYREASQIFKKALGKDHLDYGTSLYNLGGLYQVKKEYKKAESLYLEAIQVFEKNLGKDHPSYANILYKLAVLYQQTQEYGKAEPLYREVTQIFEQTLGKFHLTYTASLSSLAALYQEMKQYRKAEPLYLDVTQIFEQTLGKFHPNYAVSLNNLAALYKKIGEYRKAVSLCQEATQILEKTLGKDHPAYTASLESLTALYQEMGE
>NZ_AP019860.1|WP_151970899.1|7430628_7430808_-|hypothetical-protein
MNNLNPSELPEVSIISMCGSNYQKDSAEIASLLQDYQYYMMYKEKYKENGPRFRGVKLI
>NZ_AP019860.1|WP_151970909.1|7444703_7445933_-|hypothetical-protein
MVLDGKKFMIFFLFTLSIFAQQERTFSGLLIPSLVDQEIDAWHKVPVGQVPSISQVDFVTRHQMFHLVILFSHFAIDKNGSTNISFDMQLISPDKNVHSVRKNLLGYKEKVANKNILLMSRSLIKMAFKEKDPVGEYTIKIHARDHVAKKDCVLTKKVTLREWELGNEPKDVKEYESFMFKYYDSPSPNKAIKAYVEYTSLIDQHQQINAAGIYFFYKIFQNNTYLADHLYRLAKKSNKQVKIKAAFILQLMGKKKEAASLLEEKDKTLLKLFVLPDPYEEITPTGLDMLWCDFFATGRIEPIKKLVEALKYADYAGSIEKFSVSKKTEEDRMNAIKEATFRAANWSLTSNCQQHTLVRNYCLYIIQNEKLPGLTRIYLGLIMQKFFPNLVKVNIPKGGGEATVEIFDK
>NZ_AP019860.1|WP_151970910.1|7446582_7448817_+|tetratricopeptide-repeat-protein
MKFQTTISINQHLAHIFNCHQAVVFCGAGISLEPPAGLPDWNSLRDYTLTAIAKKDKVLRKYLKSLLSVPMIASPGKKGMTPEVVASKIAKNCEGYFESFRALEDGEPNTNHRYLAKMAKAGLLKYIVTTNFDAFIEQALQKEGLKYQVYSSEEQFASFSLENDDGVHLLKIHGCIHHPQTITATVEQEAKGLTFSKGKVLEQLLRRYHFIFWGYSGADLKIDIDYLRMVSSKDKALGFVWNFLQVEDYKEKINPHVAQLARLYENKAHITHGKLPEIFDHLIANADQIERTMYNQQQEKEWTQDKNAKLQQYLEKWAKDHVTKEDACYIFADLLKHSGETQSALKCYQYTESLYAKAKNKHRRAVTLNDIALIYDFTGDFTKALNYYRQAEKINRSLGNEGTVAAIANNIGMLYKNQGDYNTALKYYDKAQKVFKSLNNKEALAPQLNNIATIYKIQGEYDRALKNYKEVEKIDRCLGNKQGLANTLNNIGSIHDSQGDLDTALDYYQQALKIDRALGNVEGLAIRLNNIGMIYHYLEEYKEALCYLQEAKEIENSLGNKQGVADSLSNIGVIYETLDDYDIALQHYREAEEIDRSLGNKQGLATRLNNIGGIYDLHEKYQEALQYYCESEQISRSLNDVEGLATSLNNIGSIYNALGNDQEALQYLQEALEITQNIGHIELAALCSKNIGMIYNDNLMDYHTAKKYYEESTSHYFALGDDEEVLELQQLIINCSKNISSNPN
>NZ_AP019860.1|WP_151970911.1|7448841_7450446_-|hypothetical-protein
MEHQISTTKATDFFYIFRHYPYPNALELCRNNKIKGRYGTSMWQDIKNVIGFSAFALIFFIFLNHSVEWDPVTYIFLLPFLGTIGLLAVISLFFLSLAMQKVTRLYKYGTTFLHLKKAPIYFRNSIEGDIEFAGRNFTDLTVCLRYVNRLGTILYEDKLVLKDVFSRQSFSFKMPEEKFDDILYPPNANWQIEAYSEGHFSNFRATYFLPIEYKTVEEQEQQEQQEQQKSEKEQTSQSYYSNGFQHTVDHRAVSSRSSMHKSLCLQEDKTNISFAAGIIFLLGFAWTLLTILNLTTSNLSVNLLRFIAIVIYFILPVGLMVIAKTLYEYSKYHGVFGKNGEVKPWTEKGVEALPISLMDHLYDFIGIWISTLCIFSAKKNVFIILTASIFLLFFVVKTAYRYKRNCSKKTYLHFPCYPFQCGEEMNLLWECEKLYSIAEINFFLECVEETIVEKIDSNGDVKQSLLKSRVYLDHFTMLNAHKHTEAIPLNFTLPKEELEVMFQELRCRYWQLKVKVKTKTGTRFEGRYLLPILS
>NZ_AP019860.1|WP_151970912.1|7450709_7451108_-|hypothetical-protein
MKKFAFYSSVILLTLALLCYMLFWVAKNQVVSTFGFVEKTDKFQVLFDNFKLYNIRFRKKEYVQFIFVCDQAIKANNNTEGTGYKYYICWSLKGKKLRYSQQENKFPVDRRDLFIQQKIQAYEKHIAEQNGE
>NZ_AP019860.1|WP_151970913.1|7451438_7452104_+|metallophosphoesterase
MRIVAVADTHTFEKSLGELPDGDIFIHAGDLLRKGSLDELEKVSPWINSLPYKYKIIVAGNHDRCFQEDSLQACGLLKNVIYLEDSGVTIEGINFWGSPWQPQFHDWAFNLPRNALDEKWSKIPSNTHVLITHGPPKGIGDGLNSSQRAGCEYLRKRVANIRPVLHLFGHIHHDGGVWFHQSTCFANVTTWEAERMPTVFDIDPIEKIIKVVDLPKNADYE
>NZ_AP019860.1|WP_173013580.1|7452121_7454095_-|serine/threonine-protein-kinase
MSSNKRKDDDLLEITNLKSNRRITQLGIYSLKEQIGAGGMGKVFKAYHPRLAKAVAIKVMMAQTFEEKRNRFFREARLMAKLKHPNIITVHDLGSESNIDYIVMDYIEGVSLDQSLKTTRFSKRKSLETIKKIALAIEYAHQHNIIHRDLKPSNIMMEACSGEPIVMDFGLAKDVDVPEMTKDGTVIGTPRYMSPEQAEGNIAKVTKASDIYSLGAILYEMLARTPAIQGNSSVSLMCNVLEGNIKSLREVSPKISVDLDTICMKALHKDPQQRYRSARKMAEDIQCFLENKPIFAKPRKKSFPVTTAVFCGVLILLGVIASVLFTQSEQRPKSPKSAKSSKLPKLPNTQNPIVAKDASWFVVKEKPYKVAYQVKKNWPVYFHQEFPTSKFVIYEVLPQTYVCFNFCRTSSSKLSDLLPQLEKSLFDGHYKFQRQQVSAHKIKNLRGQKITYRLYKENREYYGESFYCLHVNYIYVVTAICRKSAPELTILRESMSSVQSYGQVVAEGTFQDEIHEKNFHATYKIDRSWIKHEIETPPTEVAKQYWRGAASFIQFNFWVVPSSNLTEIIRSSLHNFFSDFYTYKVVKSSHRTGNGLRGKELLVHLKVKTNPQDKRYAKVFYKLANGNVYTVFYMYPEKENEAYFSPYEKALNSLKIR
>NZ_AP019860.1|WP_151970915.1|7454493_7455624_+|ankyrin-repeat-domain-containing-protein
MSNFTNTWKYFILSIILTLSLVAQQNLLHAIQNNDINAVENIVRQVKVKEIDSSALILAIQQKKTKVAQILIDAGVDVNAPTKDHFGNTALLTAVAMQNIQATQMLLTAKANVNYQNKQQYTPLLLAALNGNIMITKLLLQAKANVNLKCNAGTPLLFASYKGYSKVVAQLIAAKADVNVVNSDGESALMLAAGLGYNNIVQQLLDNNADTSIKKDHGFDALSLACTNGNYDGVKMLIAAKANINTQTNAMYTPLALATTKGDDKMVKLLIQNNANVNLQELYGHTALMLAIWKGHVKIGNMLLAAKADINVKNVQGETAFSIAVVKGYSKLCKKLISLGANVNTRDKKGIAPIDIARKYGHKGIIRLLKKHDAQQ
>NZ_AP019860.1|WP_151970916.1|7455747_7456740_-|hypothetical-protein
MEFKHYKSIQNTSSQKYINKLVTQRRTSGSFIVQEKIHGANFSLWCDGKEVKYGRRKGFTEKGDFYDYSAIQQDCQEKVTRLYNILQEKGITQVAVFGELFGGFYPHPSTTEDKEVPIIQQKIYYSPHLQFCAFDILADEQFISVRESNKLFAEVGFFYAKTLFSGSFEECMKYPNFFPTTIPASLGLPEMEDNICEGVIIRSDDRSFFSTFQRVVLKNKNERWEEKKIVKVDEVDLSEEANTLLGELLSCVTANRLRNVISKIEQISENSFGTLMKELSRDVWDEFNKTYQLDFEKLDKFSQKKLRKQTNTACAALITENFTDIVANKF
>NZ_AP019860.1|WP_151970917.1|7457117_7457504_+|response-regulator
MKILYVENNPSFADVVCKCFLKNYNVTIVPTVQGAKELIAKSNFDILLVDYDLDDGKGNEFIAYAKKQKHQSFIIAVSSHKEGNERLKAAGANCICAKAQFDHITEIIDYVASDQLHRIQDYQTDFRR
>NZ_AP019860.1|WP_151970918.1|7457571_7458285_+|hypothetical-protein
MKKKRILYICCVVILLTIAGYFAAKAFMRSISFWESSIVAFEQQDQKKPPVLGGVVFTGSSSINYWSSLQEDMKPLPVLNRGFGGSYMHHLTHFSSRIILCYQPKVVVIYCGENDIADSISPLQVRNEFEKLVNIIHSNLPKTKIIYVSIKPPILRSLWRKSFAEANQKIEEFTTKKDNVFYVDIVSAMLDKQGKVRSELFTWDRIHINAKGYQLWTSIIKPQIIRVMNGKSLDEKE

Crispr_ID: NZ_AP019860_39

• CRISPR_ID: NZ_AP019860_39
• CRISPR_location: 7838599-7838796
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_AP019860_39

Consensus_repeat	Method
ACAAAAATAAAAAAATTACCAAAAGAGATAGGTCAACTTCATTCTCTTACTCACTTAGAG	PILER-CR

spacers of NZ_AP019860_39

>39.1|7838662|6|NZ_AP019860|PILER-CR
ACATTG
>39.2|7838731|12|NZ_AP019860|PILER-CR
AATTTATTTCGA

CRISPR arrays and Neighbor proteins around NZ_AP019860_39

CRISPR arrays

The CRISPR arrays of NZ_AP019860_39

>merge|NZ_AP019860|39|7838599-7838796|PILER-CR
ACAAAAATAGAAACATTACCAAAAGAAATAGGTCAACTTCATTCTCTTACTCACCTAGATTTGACATTGACACAAATAACAAAGATACCAAGAGAGATAGGTCAACTTCATTCTCTTACTTACTTGAATTTATTTCGAACAAAAATAAAGAAATTACCAAAAGAGATAGGTCAACTTCATTCTCTTACTCATTTAGAG

>NZ_AP019860|39|5|7838599-7838796|PILER-CR
ACAAAAATAGAAACATTACCAAAAGAAATAGGTCAACTTCATTCTCTTACTCACCTAGATTTG	ACATTG
ACACAAATAACAAAGATACCAAGAGAGATAGGTCAACTTCATTCTCTTACTTACTTGAATTTA	TTTCGAACAAAA
ATAAAGAAATTACCAAAAGAGATAGGTCAACTTCATTCTCTTACTCATTTAGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151971188.1|7835137_7837297_+|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293786
NZ_AP019860.1|WP_151971196.1|7850352_7851321_+|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|107209
NZ_AP019860.1|WP_151971180.1|7826001_7826940_-|NAD(P)H-binding-protein	unknown	unknown	gnl|CDD|187554
NZ_AP019860.1|WP_151971183.1|7829075_7830332_-|prolyl-oligopeptidase-family-serine-peptidase	unknown	unknown	gnl|CDD|224423
NZ_AP019860.1|WP_151971198.1|7851987_7852617_-|DNA-alkylation-repair-protein	unknown	unknown	gnl|CDD|132880
NZ_AP019860.1|WP_151971197.1|7851321_7851948_-|glutathione-S-transferase-N-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|238319
NZ_AP019860.1|WP_173013609.1|7846481_7846955_+|hypothetical-protein	unknown	unknown	gnl|CDD|371223
NZ_AP019860.1|WP_151971189.1|7837601_7837892_+|hypothetical-protein	unknown	unknown	gnl|CDD|340921
NZ_AP019860.1|WP_152022064.1|7839681_7840515_+|histone-deacetylase	unknown	unknown	gnl|CDD|212519
NZ_AP019860.1|WP_151971182.1|7827764_7828865_-|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	unknown	unknown	gnl|CDD|224662
NZ_AP019860.1|WP_151971186.1|7832072_7833617_+|sigma-54-interacting-transcriptional-regulator	unknown	unknown	gnl|CDD|226132
NZ_AP019860.1|WP_151971185.1|7831383_7831671_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971184.1|7830398_7831349_-|ketopantoate-reductase-family-protein	unknown	unknown	gnl|CDD|224805
NZ_AP019860.1|WP_151971181.1|7826977_7827691_-|DUF4336-domain-containing-protein	unknown	unknown	gnl|CDD|372974
NZ_AP019860.1|WP_151971187.1|7833977_7834859_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971192.1|7843366_7844770_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|224157
NZ_AP019860.1|WP_151971191.1|7840576_7842406_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_173013611.1|7852894_7853299_+|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224639
NZ_AP019860.1|WP_173013610.1|7847068_7850029_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971193.1|7844834_7846235_-|CehA/McbA-family-metallohydrolase	unknown	unknown	gnl|CDD|213987

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151971188.1|7835137_7837297_+|ankyrin-repeat-domain-containing-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	6.41824e-25
NZ_AP019860.1|WP_151971196.1|7850352_7851321_+|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|107209	cd06448, L-Ser-dehyd, Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.	1.82465e-133
NZ_AP019860.1|WP_151971180.1|7826001_7826940_-|NAD(P)H-binding-protein	gnl|CDD|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.31474e-48
NZ_AP019860.1|WP_151971183.1|7829075_7830332_-|prolyl-oligopeptidase-family-serine-peptidase	gnl|CDD|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	9.63222e-11
NZ_AP019860.1|WP_151971198.1|7851987_7852617_-|DNA-alkylation-repair-protein	gnl|CDD|132880	cd06561, AlkD_like, A new structural DNA glycosylase. This domain represents a new and uncharacterized structural superfamily of DNA glycosylases that form an alpha-alpha superhelix fold that are not belong to the identified five structural DNA glycosylase superfamilies (UDG, AAG/MNPG, MutM/Fpg and helix-hairpin-helix). DNA glycosylases removing alkylated base residues have been identified in all organisms investigated and may be universally present in nature. DNA glycosylases catalyze the first step in Base Excision Repair (BER) pathway by cleaving damaged DNA bases within double strand DNA to produce an abasic site. The resulting abasic site is further processed by AP endonuclease, phosphodiesterase, DNA polymerases, and DNA ligase functions to restore the DNA to an undamaged state. All glycosylase examined to date utilize a similar strategy for binding DNA and base flipping despite their structural diversity.	9.13129e-14
NZ_AP019860.1|WP_151971197.1|7851321_7851948_-|glutathione-S-transferase-N-terminal-domain-containing-protein	gnl|CDD|238319	cd00570, GST_N_family, Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress. In addition, GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. This family, also referred to as soluble GSTs, is the largest family of GSH transferases and is only distantly related to the mitochondrial GSTs (GSTK subfamily, a member of the DsbA family). Soluble GSTs bear no structural similarity to microsomal GSTs (MAPEG family) and display additional activities unique to their group, such as catalyzing thiolysis, reduction and isomerization of certain compounds. The GST fold contains an N-terminal TRX-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. Based on sequence similarity, different classes of GSTs have been identified, which display varying tissue distribution, substrate specificities and additional specific activities. In humans, GSTs display polymorphisms which may influence individual susceptibility to diseases such as cancer, arthritis, allergy and sclerosis. Some GST family members with non-GST functions include glutaredoxin 2, the CLIC subfamily of anion channels, prion protein Ure2p, crystallins, metaxin 2 and stringent starvation protein A.	1.47929e-15
NZ_AP019860.1|WP_151971189.1|7837601_7837892_+|hypothetical-protein	gnl|CDD|340921	cd17363, MFS_SV2, Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters. Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0.00636251
NZ_AP019860.1|WP_152022064.1|7839681_7840515_+|histone-deacetylase	gnl|CDD|212519	cd09993, HDAC_classIV, Histone deacetylase class IV also known as histone deacetylase 11. Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.	9.33497e-43
NZ_AP019860.1|WP_151971182.1|7827764_7828865_-|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein	gnl|CDD|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	6.40408e-19
NZ_AP019860.1|WP_151971186.1|7832072_7833617_+|sigma-54-interacting-transcriptional-regulator	gnl|CDD|226132	COG3604, FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms].	5.17209e-125
NZ_AP019860.1|WP_173013609.1|7846481_7846955_+|hypothetical-protein	gnl|CDD|371223	pfam10754, DUF2569, Protein of unknown function (DUF2569). This family is conserved in bacteria. The function is not known, but several members are annotated as being YdgK or a homolog thereof.	0.00579162
NZ_AP019860.1|WP_151971184.1|7830398_7831349_-|ketopantoate-reductase-family-protein	gnl|CDD|224805	COG1893, ApbA, Ketopantoate reductase [Coenzyme metabolism].	6.08521e-31
NZ_AP019860.1|WP_151971181.1|7826977_7827691_-|DUF4336-domain-containing-protein	gnl|CDD|372974	pfam14234, DUF4336, Domain of unknown function (DUF4336).	1.33618e-17
NZ_AP019860.1|WP_151971192.1|7843366_7844770_+|MBL-fold-metallo-hydrolase	gnl|CDD|224157	COG1236, YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis].	9.0057e-95
NZ_AP019860.1|WP_151971191.1|7840576_7842406_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.03258e-93
NZ_AP019860.1|WP_173013611.1|7852894_7853299_+|GntR-family-transcriptional-regulator	gnl|CDD|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	8.52895e-28
NZ_AP019860.1|WP_173013610.1|7847068_7850029_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.45142e-100
NZ_AP019860.1|WP_151971193.1|7844834_7846235_-|CehA/McbA-family-metallohydrolase	gnl|CDD|213987	cd07432, PHP_HisPPase, Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. HisPPase can be classified into two types: the bifunctional HisPPase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.	2.34404e-16

Protein sequences

>NZ_AP019860.1|WP_151971189.1|7837601_7837892_+|hypothetical-protein
MADTRVPKLKDIKENTSYYGCAFFIEKERVFNIKNCKFENCSFRTDITFDKIENCQFINCNFSNDFTLPYRSQAIEKLPPEIFTLANLTRLDLPKY
>NZ_AP019860.1|WP_151971188.1|7835137_7837297_+|ankyrin-repeat-domain-containing-protein
MKITSKTIKIVGILIFLTFAIFGYFITVSNVHQAASRGSLAKVKALVTFGVSVEAKDKEGDTVLIEAAAGGHADIVNFLIKSGANINATGENGETALIKAASSGYPEIVNILIRVGADINAENKNGETAFIKAVAAGQTKVVRILITAGIDINVTREHEEYYRITAVGIAAHKGYINVVDLLIKEGANIDDGDTPALCLAAYKGCVDTVKLLIKAGANIHGKKDDYITPLMAAAEKGHVDVVKVLIKAGVDIEFLVHYEYAETALVLAASAGHEKVVNALIEAGAIEIEKALISAARGGHVKVGHVLLKAMNTNTKDWKTGEALIAAATKGHISFVDFLIKNGADVNFVNNGDTALKVAMDSKRTKMVDFLKRMGADKWTNLMFESEKGNLEQVKSLIAKGSNPNAENYEKESALVIAAAAGQIKVVHFLIAKTDKSYYEQSLVKSASNGYASVVESLIKEVDINAKNKALKAAVANGHKNVVELLIKAGADVNDGLLTVAIYHTHTKALDMLGNSISGKPHKTDEAKLKEYTKVIKILIKTGINVNYQNTMRKTALLEATSQELICFPEIVELLIKAGADVNLSDQDGLTPLIHTISGGQHVEVVNLLVKAGANVNIKDNDGDTALIVLARQDFKSDICEKMLRILLQNNVDINARNNYGNTALISAAYFGNTTVAELLIKSKADVNIKNSKNQTALTIAESKGHRAFVELLMKRDSK
>NZ_AP019860.1|WP_151971187.1|7833977_7834859_+|hypothetical-protein
MDIQKIENYIEVNARKLDLMLYHYFFKGGTTSAVIQELKNYQNEDGGFGHGLEPDVQAKESSVLATSIAFQYLTAAKVSRDEIMVKKGLKYLADNYNKEKQAWFNLTKPCMDSPRAPWWNYEKQFDSEQWGNPTAEILGYFIMYQPESNLLEDLKDKAIHRLNEIKKPEFHEIMCFTRLYEMSGTEFQKKVFSQLSELINRTIDKNVSNWGNYSATPFSYINSHQSPLFSIFDSSLINADLERVKNSIVNGDHWEPRWDWGDLNPNVWLKAKRDWIGKLTVESVAILKNFDFS
>NZ_AP019860.1|WP_151971186.1|7832072_7833617_+|sigma-54-interacting-transcriptional-regulator
MNKDEFFRKATLRICGSLEIEKAMSSTLEFLCQWMPVDIAFLQDYDKNFDSMRTIAIATATEGRAVNLLTPLSVKARELQRKYRGQQQKVRLFSKPSEDKLSKEMLQFHGIEAKSLIVLTLESGGQVLGVLVLCSHHRMFSQKHCEWFSLLSEPFAIAMANTIQHREVIALKNLLADDNKYLHGELRRLSGDEIVGASFGLRDVMHKVQQVAALDSTVLLLGETGVGKDVVANAIHYSSLRSSGPFLSVNCGTIPDTLIDSELFGHEKGAFTGALSQKRGRFERANKGTIFLDEIGELPLQTQVHLLNVLENKKIERVGGTKTIPLDIRIIAATNRDLEEMVKLHQFREDLWFRLNVFPIWIPPLRARKVDIPALVQHFINLKSKELKLSGIPTLSPNAIAPLMQYNWPGNIRELKNIIERALIVNPSGPLNFEHFFGNSNQEKNTLDLETSLEEIDNLDEVIAKHIRQVLRKTKGKINGVDGAATLLGVNPSTLRNRMKKMAINYGRAYKNLK
>NZ_AP019860.1|WP_151971185.1|7831383_7831671_-|hypothetical-protein
MKWLENIELRTGENNRESIVQYLKKLLEEIKDKEKKQSIKVYSHAMIDTDFSVSIFHDSQKIENSGSSLGLYLTSILKEYGLVNHSVWIVLEKES
>NZ_AP019860.1|WP_151971184.1|7830398_7831349_-|ketopantoate-reductase-family-protein
MKILFYGAGVIGSLYAARLQEMGQNVSILARGQRLTDIRKHGIVLKNIMTGQETTTSIDVVEKLSPQDTYDLVVITLSKNCISEVLPILAANHSTATFLFMCNNAAGTDEMVQLLGKERIMLGFAGAGGIREDHVVNYAIVSKHKQPTTFGELNGANTPRLKQIVSMFKNAKFPVTTCSQMDAWLKTHVAEISPVANALYMCGGDNYRLAKTHKAVVYMIRAIREGYQVLQALNVPIVPSKHKLVKWVPEFVLVALAKLALNSKKATYLIGHAQAARSEMLHLANEFRTLVKKTSIATPAIDHLYTYANSGDQKKD
>NZ_AP019860.1|WP_151971183.1|7829075_7830332_-|prolyl-oligopeptidase-family-serine-peptidase
MSIKNIIFKAFAKRVPKVRGFTKRFYFAHPFLDAWFAWFPLNQIQYDGAAPGEIYNAASRIIECDGAESWIPEWSKEGDRVKKMAEDILQQGHLFSAANTFLRAYTYYRTAHLATDPDKHNEAMRKTYQELSYCFNRFRELSKIPMEKIEVPFKKDGKKTEKKMHGYLLKAKNTSDDKTVPTLIWLSGAESIAEDFYWWCGKEGMERGYNVFVVDNPGDTATRIYNEDLLNEGAGDDTLISQMDYLVEREDIDADNIFVYGISMGGYRAGRFAQIDNRMKAVIANAPMLDVSKVLDECRNVYKAPKDAQGWGKRMCWQYGIDYTKDLKEALSDLVDGTWGKFVTEPEKIKVPFLVMAGENELGGEGIRQAKEFYNRLGSNIKAKKILTTGECGQAHCQLDNFPLARQVMFDWLEDIRK
>NZ_AP019860.1|WP_151971182.1|7827764_7828865_-|saccharopine-dehydrogenase-NADP-binding-domain-containing-protein
MKKLLIIGYGNVGKLLATKILANIPEFQITLAGRNIERVKATAENLENQFTKSKVDYIKVDAADKSSLLEAFEEIDMVIVASSSLKYTRNVVEAALDTKTHYFDTQLSSKDKITVLESYRDDIQRKELIFITDGGYHPGIPGAMITWAKQKLGSLAKANIYAALKMDWSLYQYTKSTNHEMLEELKSFDCSYYQDREWKKVNWSKIPKWDFEEPYYELSCMPMVMEEIRCAPDEIEEIEETGFFISGFNPLMDRFLMPILMFGIKVLPASMYGPLGKLFEWGLKKGKPPYGVMLVADCKGSDGSLCMKVHHEDGYEITVVPVVACLKQYISGHIKPGLHLQAWVVEPKQFFADLKALGINVEVEQK
>NZ_AP019860.1|WP_151971181.1|7826977_7827691_-|DUF4336-domain-containing-protein
MSLIEYQPQQIWLKEYPIRYAGCRFNSRMTIVRLDNGSVMVHSPCEISQKLKEEIEKIGKVEFIIAPGNFHWLHVESCQKAFPNAETWICPGIEQKAPEMCFQWVLGDKPDPRWEKELDQVFIRGSRIISEVVFLHRASKTLIVVDAIEFIGPETPDTNWLLRFYWKYVTRMWSKPKPAPEYQMSWKNKRAAKKSFERILAWDFDKIILSHGDIIERDAKEMARRAWYSLLKYKQKA
>NZ_AP019860.1|WP_151971180.1|7826001_7826940_-|NAD(P)H-binding-protein
MKGFNKSCLRMESEPHELVSQIAMELMMVKDKKSVLIAGSTGYLGKHLVKAFSQSGYHVIALARNPGKLDSLADLIDKTIVIDPTNKSSLKGQMKNIDYVISALGITKQKDNLGYWDVDFLANKNILEEAIVSGVSRFAYVHVLEADRIKGDMVTAKSAFVKLLRHSPIDSTIICPSGFFSDMCEFLNMGKSGRIYLFGNGEPKLNPIHGEDLAIEIERAVANKIDWLDIGGPEIFTQNEIAQLAFSVLGKPVIIVNIPFCFAKIIILLAKLLGFRRKIGPLEFFASAFSGDMCATKFGNHHLKVFFQEQLP
>NZ_AP019860.1|WP_152022064.1|7839681_7840515_+|histone-deacetylase
MLVFYNKKQQVEENVGYSPSARKPKLVVQAWKELYPVTIQKTRALSAEEIAVAHERSYVRGILSGKIKNGFGNKSLKVAKSLQWTTGSFVCAALHAYVNRCNTFSPTSGFHHAGYNYANGFCTFCGLTIAAILLRKIHKAQRIGILDLDSHEGDGTANTIRKTNSESFIPHYSLGYYDIQQHNNNEWLENLPNLIKQLFLECDILLYQAGVDCHEDDPDVHSGHFNSEQIYLRDKLVYATCHELNIPVVTNLAGGYQKPLKKVIDLHVLTAKAFQDV
>NZ_AP019860.1|WP_151971191.1|7840576_7842406_-|protein-kinase
MNKKIGPYSIVRFLGEGGMGKVYEAYNPTLQIKAAIKIMHGTTKQELLRIQAEARAIAALTHPNIPRLYDFGEHDGCVYIAMEYIAGTTLSSLLQQKKFSVRKAIHITKTLASVLHYMHSKGIVHRDLKPSNVMVTKEQKLYIMDFGLAQKVSSYERITQTGHLVGTLAYIPPEHFYSQRPSVSEKGDIYSLGIIFYELLTNNKPFRASSTAYMVNQIISGNLSVPSKINAKVSAEVDRIFCKATHKTPEKRFSSMVSFARGLAKCNSRTTKKEPKTKIAAMVFAVVGIFVIGMVFFRSPTTKKNSAPPKAKISTLFEKLLMSIEKQQPWSNNFKQIKKMTSKNFKRITHQSVEHSQRRLIFKDLLAKVHVSNPKSLSLQKKDWQSYRNAIDAYPPFNKESGPFIHGEQIILNEGNLYQYAAAFFYKRPISQPFVLEFDYNISLTMSEKPCDGFAFMFNKKLPPFGVLPPQGAFGGFIFDGSGYGVLFKTFEPSQNVISVAVDQGNYTQNSFEKIQDVEIPATVWINAHSKRPGTINEFVSYPTKVFENNRWKKVRIFVMDKVIALYLDNKEIVFVEESIDFSSNFIGFSCATGALAAKHKIRNIKFLW
>NZ_AP019860.1|WP_151971192.1|7843366_7844770_+|MBL-fold-metallo-hydrolase
MKISFLGGAGGVTGSKTLLEIGKEKYLVDYGLYQGSSKSREKNWKRFHIASQVSAVFLTHAHIDHSGLLPRLWKDGFRGKVYCTRETFKLCEILLVDSAKIHEEDAKYANKKQYSRHKPALPLYTLEEVEEILKRFEVVNFEKEIKVSKNISITFYWSGHILGSSFLRIRYKDENGQEKKVVFSGDIGHKRNVLLNPPALLCEMDYLILESTYGDKLHARIPAKEVLGMYLNAILKRSGVAVIPSFSVGRTQDVLFLVKELMDENKVPKVPVILDSPLSKKANKIFNECFTKGCVKDEIMEKGDIYPTTISEVESAEESKNIANADGPMIIISASGMIDGGRVVHHVKNRVVDRKNGIILVGYQPKGTKGRFLLDGEKMLRLHKQELPVNATIFYVNSLSAHGDYLDLIEWIKDSKVDPKLIILNHGEENGSKHFKMLIESQLEINATVAEYGEEFNLDNIYIKNKL
>NZ_AP019860.1|WP_151971193.1|7844834_7846235_-|CehA/McbA-family-metallohydrolase
MDKLMLFFCILLSTQIFSESLVIEKKFFPPKSTDIYRYVPFDVPDDVVEIKVSYSYDRKKHTVDIGIFDSNGIGKKGFRGWSGGSKSEFIIAEHNATAAYLPGPIYSGTWQVILGLYQVEPSGVDIKIEVEFRTSSANSFAGPRFLWNADQVLESNTRWYKGDLHMHTNHSDGKQTIEDLVAYAKENQLDFLAMTEHNTCSHHFEIPTYANNEVLLILGEEVTTTQGHANVWGLPQGYWIDFRINRNNSINDIVRDAHSVGALFSINHPFGPCGGCYWNHSDLEDYDSIEIWNGYWDPTDYLALQMWDRLLQQGKRIPIVGSSDSHKKQDPIGKPTTHVYASNLSQKAILTAIKNGRAYITKDISPTAIEFSAYLENTNDSAMMGDILNVRKQQEVLFAIAISGCKQGKVNVICNGRKIISKNISQLKNGMLEFSHIIVKDSYFRLEVEDDYDMIAVTNPIYVDMK
>NZ_AP019860.1|WP_173013609.1|7846481_7846955_+|hypothetical-protein
MQRQPFGMLLRLSFLGLLIAFIYGMRVFMSTLPLLSSSSQKAMVISIAIVSILFVIACVVLMFLFLRRNHRFPKLIVSFCAFNALIILVMLPFTDGVFDSVIAIVSAIFWILYYTNAPRVQEIFIEKLGEKTYYTSTSVQPPKKISNDSALQKLWKH
>NZ_AP019860.1|WP_173013610.1|7847068_7850029_-|protein-kinase
MGVVYKAQDTKLNRTVAFKIILVDIEERQKQRFLQEARAIAQVDHPNVIKVFEVGEEPLCYYTMEYIQGGTLSQCIAQKLLKPTALANIFYKLADALYVMHKQKIVHRDLKPSNIMLSDSGEPKVMDFGLAKVLDSQISQSKDFLGTPAYMSPEQINNDNVDAKSDIYSLGASMYEGLTGRPVFQGDEIFNILYQIVQDDPIDPRRLNPDIPVDLEAICLKCIEKKPRKRYVSMKFLAKDLKNFMENRPISARPPTKIKALQKWVLRNKAITTIFFVALIAMVLSISIVIFSLHQQTQIKIEEAKKLNHEKNKVEMARQQAVTAHEKAQGLVVELRGVKTQLEQSLYRHTIALVDMYNRTGDISKVNYYLNKTQFCPPKARGWEWYWLYRQSNQQLFTLEHENYRSSNWREYFNCFFSRDGKKIFAAISAGIQVWDTNTKAVVKVIRLKKTPLCSDLSPDGRTILFNTVDGNLQLLDVQTQKVIRKYSHNIIKPEHCTFSPDGSMVACSGKEGVYIWKTTQKKLFQKLEKHEKIYACAFSPDNKKIVTGGTFETLQLWDIKSGKHLKEFKGHKNIISYCVYSPDGNKILSTSYDGTMKLWNREGKLLHSFEDASTPEKLLKQALSSCHFSPDGRRVISTGKDNILRLWSVKTGKLLARLKGHNDHILNADYSSDGKNVVTISDDGTLKVWSTLKKNNPQILRGHIAKVNFCSFSSKGNKLISASSDSRLIIWDMKSKKPIKTITGHWGSVRGSLFNESGTKIVSCGKDQTLRIWNNQGKLLKRVTFGEAIRSCTWTPNENVAVFIDKKLIFTDMNTGHQKTVLETAGNIRKIAFHPKQPLILILLESKEIQLRNTNTWKLSAKKKIPDTEATSLTFSPDGKLFVTTHPESINVWETKTFKLLKKLQGHDGEVLCGIFTKDGKRFISNHDHSLQIWNIDTGEPLLTLEGHTGIIEYLTLSKDGTKIASCAQDHTIRIWDIDSFTTRN
>NZ_AP019860.1|WP_151971196.1|7850352_7851321_+|pyridoxal-phosphate-dependent-enzyme
MPIYFTFRHSKSIQEEPKLHIKTPLLESRSLSQKVPGTVWLKMDALQPSGSFKVRGIGFACREYAHRGTKKFISSSGGNAGVAVAFCGRKLNIPVSVVVPKSTTERAKELTRLENAEVIVHGDTWNEAHLYAMELVDDSAAYIHPFDDPLLWQGHASIIDEICENDITPDLVIVSVGGGGLLCGVIEGLQRNKLKNTRVLAMETQGAESLHLSLQQGSIVTLPEITSIATSLGAKKIAQHTFESAQKCKVISNVVSDSQAIDACLQFIRDHRIVVEPACGAALAPLYQSSPFLREYNNIVVIVCGGVVATLEQLHQWQKSVG
>NZ_AP019860.1|WP_151971197.1|7851321_7851948_-|glutathione-S-transferase-N-terminal-domain-containing-protein
MRLYGTPLSHFTRKIRILLLELEVHFEFVDIGNVGDNNIEVFSGNPLMRVPILEDNHCKLFESDNIARHIVKNYASEDQFGVCNCDPQVLNILAVISGVMEAEVRLILAERGGMKDIYQHHFFQKTRDVAINGLEWLARQDKFINKQDLCYGHIASVCMWDHLSHYNLFDLTPYAPLKQLSEKWNKKSSFMTTRPKFTNEKNRASKIR
>NZ_AP019860.1|WP_151971198.1|7851987_7852617_-|DNA-alkylation-repair-protein
MKINEILPLLDGDSVKMGDIKKMAKQIKVDHDLASELWATKKYYPRLLAVLIMDKNRLDQDYLDKIVQDLKSHEKDESNYISEWLLGNQLVKNKKNKKLLESWQEHPEPILRRLFWYYQARLRWTGKIQENSSELMDYLEKNMEKADPLVQWTMNFCVGWIGVFEEQYRPRCIALGEKLGLYKDEHVSKGCTPSYLPAFIEVEVGKRNK
>NZ_AP019860.1|WP_173013611.1|7852894_7853299_+|GntR-family-transcriptional-regulator
MLLDIKVRTGSAVPIYQQIIDQVKRAVAIEKLSPGDQLPSVRALSKKLTINPNTVTKAYGELVREGIAESRSGRGLFIIERVQFYSEEERLKRLETAIDEFVNKIALLDFEANDVWERLRVKLKEISQRKGRDE

Crispr_ID: NZ_AP019860_40

• CRISPR_ID: NZ_AP019860_40
• CRISPR_location: 8083810-8083934
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_40

Consensus_repeat	Method
GTGTCATCCCTGACTTGATCAGGGATCCAGCGCTT	CRISPRCasFinder

spacers of NZ_AP019860_40

>40.1|8083845|55|NZ_AP019860|CRISPRCasFinder
TTAATTCATCTTTATATTGCTGGTTTCCCGCTTACGCAAGAAGGACATAGTTCGC

CRISPR arrays and Neighbor proteins around NZ_AP019860_40

CRISPR arrays

The CRISPR arrays of NZ_AP019860_40

>merge|NZ_AP019860|40|8083810-8083934|CRISPRCasFinder
GTGTCATCCCTGACTTGATCAGGGATCCAGCGCTTTTAATTCATCTTTATATTGCTGGTTTCCCGCTTACGCAAGAAGGACATAGTTCGCGTGTCATCCCTGACTTGATCAGGGATCCAGACGCT

>NZ_AP019860|40|33|8083810-8083934|CRISPRCasFinder
GTGTCATCCCTGACTTGATCAGGGATCCAGCGCTT	TTAATTCATCTTTATATTGCTGGTTTCCCGCTTACGCAAGAAGGACATAGTTCGC
GTGTCATCCCTGACTTGATCAGGGATCCAGACGCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151971368.1|8086115_8086949_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971358.1|8072250_8075184_-|fused-MFS/spermidine-synthase	unknown	unknown	gnl|CDD|226713
NZ_AP019860.1|WP_173013629.1|8093525_8093678_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971370.1|8088185_8089250_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_151971367.1|8084021_8084276_+|DUF4212-domain-containing-protein	unknown	unknown	gnl|CDD|132686
NZ_AP019860.1|WP_151971357.1|8071798_8072182_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971362.1|8078497_8079463_+|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|226952
NZ_AP019860.1|WP_151971365.1|8081118_8082165_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971363.1|8079465_8080266_+|ABC-2-family-transporter-protein	unknown	unknown	gnl|CDD|226953
NZ_AP019860.1|WP_151971361.1|8077455_8078505_+|dipeptide-epimerase	unknown	unknown	gnl|CDD|239435
NZ_AP019860.1|WP_151971366.1|8082647_8083799_+|MFS-transporter	unknown	unknown	gnl|CDD|340882
NZ_AP019860.1|WP_151971364.1|8080262_8081051_+|ABC-2-family-transporter-protein	unknown	unknown	gnl|CDD|226218
NZ_AP019860.1|WP_151971373.1|8091877_8092567_-|response-regulator	unknown	unknown	gnl|CDD|223816
NZ_AP019860.1|WP_151971371.1|8089228_8091151_-|NAD(+)-synthase	unknown	unknown	gnl|CDD|235057
NZ_AP019860.1|WP_173013626.1|8076743_8077451_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223999
NZ_AP019860.1|WP_152022067.1|8084287_8086093_+|VC_2705-family-sodium/solute-symporter	unknown	unknown	gnl|CDD|274698
NZ_AP019860.1|WP_151971372.1|8091143_8091869_-|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl|CDD|235420
NZ_AP019860.1|WP_173013628.1|8092636_8093545_-|EamA-family-transporter-RarD	unknown	unknown	gnl|CDD|225510
NZ_AP019860.1|WP_151971359.1|8075400_8076696_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	unknown	unknown	gnl|CDD|224117
NZ_AP019860.1|WP_173013627.1|8087431_8088175_+|metallophosphoesterase	unknown	unknown	gnl|CDD|277317

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151971358.1|8072250_8075184_-|fused-MFS/spermidine-synthase	gnl|CDD|226713	COG4262, COG4262, Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only].	6.84532e-23
NZ_AP019860.1|WP_151971370.1|8088185_8089250_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	2.86295e-44
NZ_AP019860.1|WP_151971367.1|8084021_8084276_+|DUF4212-domain-containing-protein	gnl|CDD|132686	TIGR03647, Na_symport_sm, putative solute:sodium symporter small subunit. Members of this family are highly hydrophobic bacterial proteins of about 90 amino acids in length. Members usually are found immediately upstream (sometimes fused to) a member of the solute:sodium symporter family, and therefore are a putative sodium:solute symporter small subunit. Members tend to be found in aquatic species, especially those from marine or other high salt environments. [Transport and binding proteins, Unknown substrate].	3.10927e-33
NZ_AP019860.1|WP_151971373.1|8091877_8092567_-|response-regulator	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.68347e-92
NZ_AP019860.1|WP_151971362.1|8078497_8079463_+|ATP-binding-cassette-domain-containing-protein	gnl|CDD|226952	COG4586, COG4586, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	2.06889e-115
NZ_AP019860.1|WP_151971365.1|8081118_8082165_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	3.1441e-44
NZ_AP019860.1|WP_151971363.1|8079465_8080266_+|ABC-2-family-transporter-protein	gnl|CDD|226953	COG4587, COG4587, ABC-type uncharacterized transport system, permease component [General function prediction only].	5.89428e-19
NZ_AP019860.1|WP_151971361.1|8077455_8078505_+|dipeptide-epimerase	gnl|CDD|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	6.95576e-118
NZ_AP019860.1|WP_151971366.1|8082647_8083799_+|MFS-transporter	gnl|CDD|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.30939e-48
NZ_AP019860.1|WP_151971364.1|8080262_8081051_+|ABC-2-family-transporter-protein	gnl|CDD|226218	COG3694, COG3694, ABC-type uncharacterized transport system, permease component [General function prediction only].	6.42175e-32
NZ_AP019860.1|WP_151971371.1|8089228_8091151_-|NAD(+)-synthase	gnl|CDD|235057	PRK02628, nadE, NAD synthetase; Reviewed.	0
NZ_AP019860.1|WP_173013626.1|8076743_8077451_+|alpha/beta-hydrolase	gnl|CDD|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	0.000902486
NZ_AP019860.1|WP_152022067.1|8084287_8086093_+|VC_2705-family-sodium/solute-symporter	gnl|CDD|274698	TIGR03648, Na_symport_lg, probable sodium:solute symporter, VC_2705 subfamily. This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.	0
NZ_AP019860.1|WP_151971372.1|8091143_8091869_-|UDP-2,3-diacylglucosamine-diphosphatase	gnl|CDD|235420	PRK05340, PRK05340, UDP-2,3-diacylglucosamine hydrolase; Provisional.	1.22394e-41
NZ_AP019860.1|WP_173013628.1|8092636_8093545_-|EamA-family-transporter-RarD	gnl|CDD|225510	COG2962, RarD, Predicted permeases [General function prediction only].	1.37269e-92
NZ_AP019860.1|WP_151971359.1|8075400_8076696_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme	gnl|CDD|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	8.10441e-05
NZ_AP019860.1|WP_173013627.1|8087431_8088175_+|metallophosphoesterase	gnl|CDD|277317	cd00838, MPP_superfamily, metallophosphatase superfamily, metallophosphatase domain. Metallophosphatases (MPPs), also known as metallophosphoesterases, phosphodiesterases (PDEs), binuclear metallophosphoesterases, and dimetal-containing phosphoesterases (DMPs), represent a diverse superfamily of enzymes with a conserved domain containing an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. This superfamily includes: the phosphoprotein phosphatases (PPPs), Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	6.61301e-06

Protein sequences

>NZ_AP019860.1|WP_151971366.1|8082647_8083799_+|MFS-transporter
MPQISASLIFFLSAFTLGTLYCPQPLLPIYSDIYKISLSQTALLTTFALIPLSFFPLIYGIISEYISPIRVLKFSLWGLAFSTFLFTLGDNFTYLLLIRLLQGFFIPGILTSTVTYISQTTIPEKIPQYMSLYVIGTIVGGLGGRLLSSFLATHVHLNAIYFFLSASLIIMQCFTLRLQQKPTKPANKIYLSDIFKILISPIYREILLTIFSVSFVFACVMNYIPFRLRELDGFSWIHIIYLGYTLGIVTSFLSQRLQKRYNVVNIACIGLVIFLSSLLLLLTTTPLYIFIIVFAFCGSMFFVHSILMSFVNSVGQESKGLVNGAYVAFYYSGAVTGSYFPGIVYEHFGWVSYIWLLFAMLFISSLIFFVTMKVKSPSCQVKA
>NZ_AP019860.1|WP_151971365.1|8081118_8082165_+|protein-kinase
MTAKELAFIPKQFDIQKVIKSHKYYKILFAKNQDIQQFVFIKALTLDGAQDIFITNEFRRECRIAKKMSSFAHPCIPRILYVEHGMGPRFYIMEGTAGSTLEEYMTQHKIPQEIATRITLQIAQGLDALYTQFEIIHRDLSPDNIYLTRDLQPKICNLQSIKNADVTTITSHGGVKGSMLFTAPEICSEHFDYSIQSDMYSLGLIFLYMLQNKLPIESVEDIFDFDVTQLSLEEYSAQPILLKMLHKNPNERFANYAELINELQPIYNTYTPATVTTSGPQTDVADARLSMWEAKLDNIAKKLAILEQKQENLTQALNVTLTGMNNKITQLEAENQRIKQYLSQMFNK
>NZ_AP019860.1|WP_151971364.1|8080262_8081051_+|ABC-2-family-transporter-protein
MTRYFRLYLHFLRFSFSKAMEFRVDFFFRIVMDCFFYAINIAFYQVLFLHTSTLGGWNEEQAMIFVAAYILVDALQMTIFSTNLWWFPIFVNRGDLDYYLVRPVSSLFFLSVREFAANSLCNVFIAIGIMIWAISSYSQPLIWWKILLFVLLVVNGTFIYYMVHMLFLIGVFWTHSARGFDSLFRHLCLVHERPDGIFHGATRTVFTTVLPFCLMCSFPARLLFEDFQLSVLLHILITTMLMFFVLRWAWKFSLKAYSSASS
>NZ_AP019860.1|WP_151971363.1|8079465_8080266_+|ABC-2-family-transporter-protein
MWTLQVFTLEMRKIFSYRIDFWTQFIAYIVVWVGISYFLWSSIFAQKGIDSIGDYSFHALMLYYLITASVAKIIRGQDIGQISREIYQGELSRYLVYPIPFFLYKFVCHLAHSFMYFIQLIFAIVFFACVFGLPVEITITYDRVLMCFLFLLLSCYLHFSIAAVIEIVSFWADNVWSLLVMLRFISGLLGGALLPLVLFPEWAQKILYTLPFPYLISFSSEIFLNKVTYAQTYKATFIVFAWSVFFNIIFAVVWKKGLRQYSGVGI
>NZ_AP019860.1|WP_151971362.1|8078497_8079463_+|ATP-binding-cassette-domain-containing-protein
MIEVRNLKKSFRVHVKKPGLLGSMRSLFVRNWVEKHALKGVSFNVEPGEIVGLLGANGAGKTTLVKTLAGIVYPSDGDVKILGHVPWERKNEFRRQIALIMGQKAQLWWDLPAEDCFLLLREIYSIPRQKFHDKLNFLSETLGITEQLNIQIRRLSLGERMKMELIAALLHEPRVVFLDEPTIGLDFTAQKAIRDFILQYRSQHQPAMILTSHYMEDIKALCKRIIIIREGEFIYDGPLQNIVNTYTKHKIVSLHLEKEISPPNIPHEIVAAEPQFLKIKIPRDQVAPSVNSLLQSLPVADLTIEEQAIEDVIEALFRGEM
>NZ_AP019860.1|WP_151971361.1|8077455_8078505_+|dipeptide-epimerase
MQIKDVKIVHKKLPLKKVFRTALRTATEIPLIEVEISTNEDTIGRGTTSAAAKVTGETTSSICAAIQDYIFPSIAGSSLLNVQQILHSITTSIPKNYSAKAAVDMAVYDLYCKSLQIPLYKYLGVYRTKLSTHMTVSLGEIEQMCCDAQEAVNNHFSSLKIKAGKDFRHDIEAIRQIYKTVGNSVRLGIDANQGWKKRDAVTAIRALQEIPNIDFVEQPVVAHDIEGLKWIKNRVDIPIMADESIFSYSDAMRVIREDAADLINIKLLKCGGIFPATKILHAAESAGIECMLGCMMEGPISIACGAMFACAHKNITRIDLDSLYSLRNFTLPSYIYYGEGQIELKVNHD
>NZ_AP019860.1|WP_173013626.1|8076743_8077451_+|alpha/beta-hydrolase
MHGLESGLQGKKSHYLHSHFANTYTPDMQMSLLNVRKKHSVLRNICKTKLFRVWFVLLLLCVTISCFMSTTHTIVSFVIGILVFLAVKKHLIQRALDISLQQCVTVQSNALQEFQPHIVVGSSWGGLVALICLSQNAHSCPVILIAPPVKMILNKIDPSEKKWLNMCEMAKQHSDQIYIVHGEKDQTVPLEDSQEFIEKAGGILQVIPGGDHSLNDSLLEDDTPYALKNIITNLR
>NZ_AP019860.1|WP_151971359.1|8075400_8076696_+|SUMF1/EgtB/PvdO-family-nonheme-iron-enzyme
MCSRNVRIKCICFALLMVSAFSQEQTKAKIKRFHANLSMTQRSIERVDREILTLTKGIRELQKQQTQMVAAIAKHQQSIKKSQVDVVSKNIAKKIALLQELTSAMENTSQLHAFNERLQVESKKMQRLIQVKKQINSEVFNHQKHIVQYKRQLSEISKKMDISKSVLAKTVRKRKILKKNALIYKKQRNLAAQEYVQQKKQLKKKRLLAAYAAKKKREMAEKKKREAAEKKRREDNERKKRALAYAQRKKKSSRNNIRENPDSEEEAAIASLLLLKTAEDVAEDVADATEDQRKNNKLIPRIVRKQNPKDGAWMTRVGSFWVYEKPITNTQYWETFRGMYYNNAQKNAQAVTEITFRDAQEYARWAGAKLPTYSQLQKLPKNLSGNAWEWTNSTYRKKSAHVIFNKIQKPRLLSDAKEHTQVTFRLILPAR
>NZ_AP019860.1|WP_151971358.1|8072250_8075184_-|fused-MFS/spermidine-synthase
MNKSIVKWVALLLFFSGGCSLSYQILWRKLLIPVMGGSTWATTTILATFMTGLALGSFYSEKIRTKNPLRVYGYLELAIAVYSVVALWIFPYASWLLAPLYSLIDANFIFFIILQFLVAFLLFVIPSFLMGITLPMLVFHFSQQKDLFANTATLYAANTFGAALGVVFATFVLLPWCGITYSAYMTSLLSAGIAMSALRMSRHSHCEVPQSTAATWVPDSLCLWAFMCGAIGLFLEISWTRILVVVFGSSTYAFSIILLSILLSIALGSWWVRKFILLQDNYRSFLYTLLCGNILFIALSLYIINFLPNFFMSLTYLCNENLVLFLILQGVTTGIVIFVPMTLLGMLLPVIIEGYKLKTQATSKAVTYVYGYNTLGAIFGSMGAGFFCIPIFGVHASLKFCIYLGCAVLLLTLLKETSRQVPKLLCVVFTALLVFISPTMNVQAFHKSLFRKALVKKEKLSYDAKLIYAEDGINSTVTVYRDFYHTSLNINGKTDASTSQDLDTQYLLGHIPMFLASQSKNVFVLGLGSGATVHAVATHKDAQVDVVEMEEAVITASGYFKAINGNVTKNPRVKIYVEDARTFLKYRDKTYDVMISEPSNPWVEGSGSVFTKEFYDIVNSKLNQGGVFCQWIQGYEISRQTFDTILATLKATFPHVVIFRQDFDFLCIATREPLKLTYKELQNKFVGKELQKTLKRIGIHNPAELLCGLYGSLPDDTVHVQKINRDDNVILEYRAPLEMYRGINFKPQRLKTADYFARLCTYFYSDLSADEAVEKVILALRTLQPEEWPRIKELAKYSKNQAHMEAIASIAEQRHKMLQNKDEMVREAAVLITQGKVQPALYKLEEIISLDPLDPSGYRLLAKIYTRLQKVQLAMTCYEQIVWLAPEDYVSRLNVGLLTYQNGKKEVAEQHMRETFEIYPQYLEGRLAWIALFVNNKEFDKAKDFYRKSLAMINKKDRDEFKMKYIALMEKKDKEKK
>NZ_AP019860.1|WP_151971357.1|8071798_8072182_-|hypothetical-protein
MYTLWSILATRTDIEDIAGSVFGWAIFFLFIAYVFNDDKEEKDKKKPKEKKVKSWILLVFFSMIMITSFSAVMGSLVVSRTRSFSGAAISFCIFYLAAFGVKKMLNFRELFLGGMRRSDTKVGKRDI
>NZ_AP019860.1|WP_151971367.1|8084021_8084276_+|DUF4212-domain-containing-protein
MKNKNAYWRANLRLIGICLFIWFLVSFVFAILLVEPLNRFSLGGYKLGFWFSQQGSIYVFVALIFFYSWQMNRIDHQFGVYEEE
>NZ_AP019860.1|WP_152022067.1|8084287_8086093_+|VC_2705-family-sodium/solute-symporter
MELQTLTYWVVGLSFALYIGIAIWSRASSTSEFYVAGKHVHPIANGMATAADWMSAASFISMAGLIAFLGYEGGMYLMGWTGGYVLLATLLAPYLRKFGKFTVPEFIGDRYYSQLARVVAVVCLIFISFTYVAGQMRGVGIVFSRFLEVSIDSGLFIGMGIVFIYAVLGGMKGITYTQVAQYCVLIFAYTVPAIFIALQTTGSALPQIALGAEVLDGSGTLLAKLDQSLTDLGFGAYTTPFNDKSMIDVFAITLALMVGTAGLPHVIVRFFTVPKVRDARTSAGWALVFIAILYTTAPAVGALARTNMIQTVNGTEQQGTAYKEIPEWFKTWEDAGLIAWYDHNNDGRVQYAAGNAFTGKPEFDGDKRGKHGERIVKNPSEGKTAKNAPFANEIYVDRDIMVLANPEIAGLPNWVIALIAAGGIAAALSTAAGLLLVISVSVSHDLLKSTFTPQISEKNELLAGRIAAGVAIGIAGYLGLHPPAFVAQVVAFAFGLAASSLFPVILLGIFSKRMNKWGAISGMLSGLIFTMGYIIYFKGVFISPIAANVPENWLLGISPEGIGSIGMVINFAVAFTVSHFTSPPPAEVQELVEDIRVPQNS
>NZ_AP019860.1|WP_151971368.1|8086115_8086949_+|hypothetical-protein
MNKLFILLLFTTVYAQTTHDIVAHTFSVLKQQHIFRNHKQQDKEPRPLYLAQQAFTEAKQADKEVQMRDRLNIALAHANQARFLHSASLNSLQIQKRRGWRNGLDTVTFGISSIFLESNEEKYSEDGKVISSAAYRYLLAVYIARQAQKALKEKPAQVKHEIKWEKILQRKMLFAKAKKVDQLTITQFKTLTSELFYRSLTMAIRSLKKSNKTSLINQYIDYLAKLAPQQKKVWLQRKDIVARVLKLSGAPSDLEYERDARTILNCEDALRILSEFD
>NZ_AP019860.1|WP_173013627.1|8087431_8088175_+|metallophosphoesterase
MIAIIASIHGNLQALQAVIEDIDKRNIKTIYCLGDMVGYGPNPRECIEIVRDRCEFCLRGDFEENIMRQSLSSTPGVLEITIEWIRNQLYSESYPETQNNELWDVIANAKQKVYRDRCLYAHNASPNNGYAVPLSFIQLKYTMSHFSNYNVFFCGGSHVPGVFTEEYQYHYAADINNLFYLSPTSKQIIDVGSVGKPQDRNNHACYAILNDQTLQWIRVEYDINKTIEEIENCTLPNTIADYLRREI
>NZ_AP019860.1|WP_151971370.1|8088185_8089250_-|leucine-rich-repeat-domain-containing-protein
MAGGLLVGISNKRKAQVIEKTLVSRQTLKEVKSNSHYAGCTFYLDDNYSIENTSFDNCSFRSDAIFGNLPDCTFENCNFSATFVLHLSGRYLSAIPEYVFSLRDLTHLLVFSNNISCIPDEIGNLQNLEYLDADHNQIESVSREIQQLRKLSMLHLSGNKIGRLPMQIGQLQNLRYLSLSHNTIDKIPCEIGHLTALTLLDISHNSIKSIPEQSERLQSLNLLSLYGNNITNVPKEIWEKYPQEHKESGGRPVFNKYHNENVKSGALPPEVGELQNLVELHLSGNYICEIPNEIGMLRNLNELHLAYNEISSIPSEIGQLQNLRELWLNNNEIEELPKGIAKLENLKQLHLPTD
>NZ_AP019860.1|WP_151971371.1|8089228_8091151_-|NAD(+)-synthase
MTNQPYGFIRTAAASPKLKVADITYNTQQIIQTIHEAHAQKCQIVVFPELCITGYTCGDLFYQDLLIAKSRQAVNIIAQQTKDLDMFIVLGLPVLVQSKLFNCAVAVLGGEVLGVVPKTHLPNTNEFYEKRWFCSANDNVYDTVYWEDKAVPFGTDLLFCATNFRECIIGMEICEDLWAVAPPSGDMAINGATIICNGSASNEYIEKVDFRKSLVAMQSARCLCTYLYASCGPGESSTDLVYSGHSMIAEAGAIVKESARFRSEGSITVADVDLQKIVCQRLKNSTFFTSNSPKKRRRVAFSFATITNPQTLERPLSRFPFIPADNKEDAYYEILELQSIALAKRVEHIGRCKLVIGVSGGLDSTLALIVCAKAFKRLNRDPKDIVAITMPGMGTTTQTKGNAERLSESLQVTLRTIAIEKAVMQHFADIDHDPQQHNITYENAQARERTQILMDVANQVGGFVVGTGDLSELALGWCTYNADHMSMYSVNVGIPKTLIQHLIRWYATTVDDTLKEILEDIANTPISPELLPHDNDEIQQKTEDKVGPYILHDFFLYHHLYFQFSPQKIFYLAEQTFREEYRSEEIRKWIQIFYKRFFQQQFKRSCLPDGPKVLAVSLSPRGDWRMPSDAVGNLWLEDCL
>NZ_AP019860.1|WP_151971372.1|8091143_8091869_-|UDP-2,3-diacylglucosamine-diphosphatase
MKKVIFVADLHIDIGETKRLQAFEKFLATEQAPIYIMGDLFNFWAGNAQGNLGYVRHFLRFLRRICAKKQIFFLAGNRDFLFVPFFAKRLKGNTIEDGYTLTLGKHRVVLYHGDALCTGDKSYLEMKKWLQSDLIYYISRFMPSNVCVKIGQKFRQTSQKAIRKKAQKDMGLNFQFILDILDDLNQDVMICGHTHKPQFKVLREEKDNDKELYVLPECKEQCISYLEWSDNQFTYKEKNYD
>NZ_AP019860.1|WP_151971373.1|8091877_8092567_-|response-regulator
METILVVEDDPAILLGLTKNLQFEGFNVLCAEDGEEALEIIFNKPIDLLLLDVMLPKLNGFEVCKTVRKKNLGVPIIMLTAKDKEIDKIMGLDLGADDYIAKPFSVRELIARINAVLRRKRKYEDKANDVLLFGNIKVNFQGRTVHKDDERVDLSPKEFDVLKLLVQNKGKVLSREEILNKVWGYDYFGTARTVDNFINKLRQKIEEEVTQPLYILTVRGIGYKFQIPE
>NZ_AP019860.1|WP_173013628.1|8092636_8093545_-|EamA-family-transporter-RarD
MGYIFVICAYFLWGILPLFWKQLAHVPAAEIIFHRMLWSFVSMGVLLTALRNWKWIALLRESPKMLLWGFLSAALIAGNWFIFIWAVNNGYIVEASLGYFINPLLSIALGIIVLKEGVRRVQIFAIIVAALGVCYLTFVYGHFPVVAFVLAATFGIYGLIRKMIPFGALSGLFVETAFMFLPAVFCLVHLESSGNGTFSDSSFSTQALLLITGVATITPLLFFAAGVRKIPLYTVGFLHYIAPTLQFLIGVFVYNEKFSFSQLVGFCFIWLAIVIFCVESYVFYKNNKAVMVGLSPATDDSA
>NZ_AP019860.1|WP_173013629.1|8093525_8093678_+|hypothetical-protein
MTNIYPTIYSTNKYHNRHNRNSNNRNRNRHRSRSRNRHRDLDRDHDRQCH

Crispr_ID: NZ_AP019860_41

• CRISPR_ID: NZ_AP019860_41
• CRISPR_location: 8095651-8095728
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_41

Consensus_repeat	Method
CAAATGTGCGGAATTCGCACATT	CRISPRCasFinder

spacers of NZ_AP019860_41

>41.1|8095674|32|NZ_AP019860|CRISPRCasFinder
TTTTAAGTACTCAACATGTAAAATCTTATGTA

CRISPR arrays and Neighbor proteins around NZ_AP019860_41

CRISPR arrays

The CRISPR arrays of NZ_AP019860_41

>merge|NZ_AP019860|41|8095651-8095728|CRISPRCasFinder
CAAATGTGCGGAATTCGCACATTTTTTAAGTACTCAACATGTAAAATCTTATGTACAAATGTGCGGATTTCGCACATT

>NZ_AP019860|41|34|8095651-8095728|CRISPRCasFinder
CAAATGTGCGGAATTCGCACATT	TTTTAAGTACTCAACATGTAAAATCTTATGTA
CAAATGTGCGGATTTCGCACATT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_152022068.1|8094796_8095549_-|PEP-CTERM-sorting-domain-containing-protein	unknown	unknown	gnl|CDD|379155
NZ_AP019860.1|WP_151971368.1|8086115_8086949_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013629.1|8093525_8093678_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971384.1|8107666_8108509_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971370.1|8088185_8089250_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_151971375.1|8095837_8096938_+|methylated-DNA--[protein]-cysteine-S-methyltransferase	unknown	unknown	gnl|CDD|223200
NZ_AP019860.1|WP_151971373.1|8091877_8092567_-|response-regulator	unknown	unknown	gnl|CDD|223816
NZ_AP019860.1|WP_151971383.1|8106107_8107550_-|HAD-IG-family-5'-nucleotidase	unknown	unknown	gnl|CDD|377556
NZ_AP019860.1|WP_151971371.1|8089228_8091151_-|NAD(+)-synthase	unknown	unknown	gnl|CDD|235057
NZ_AP019860.1|WP_151971380.1|8102682_8104521_-|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl|CDD|133475
NZ_AP019860.1|WP_151971378.1|8099472_8101200_-|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl|CDD|235629
NZ_AP019860.1|WP_151971381.1|8104551_8105421_-|hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240628
NZ_AP019860.1|WP_151971376.1|8096934_8097834_-|FkbM-family-methyltransferase	unknown	unknown	gnl|CDD|273628
NZ_AP019860.1|WP_173013627.1|8087431_8088175_+|metallophosphoesterase	unknown	unknown	gnl|CDD|277317
NZ_AP019860.1|WP_152022067.1|8084287_8086093_+|VC_2705-family-sodium/solute-symporter	unknown	unknown	gnl|CDD|274698
NZ_AP019860.1|WP_151971379.1|8101500_8102604_+|hypothetical-protein	unknown	unknown	gnl|CDD|224113
NZ_AP019860.1|WP_151971372.1|8091143_8091869_-|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl|CDD|235420
NZ_AP019860.1|WP_173013628.1|8092636_8093545_-|EamA-family-transporter-RarD	unknown	unknown	gnl|CDD|225510
NZ_AP019860.1|WP_173013630.1|8097977_8099429_+|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl|CDD|224089
NZ_AP019860.1|WP_151971382.1|8105430_8106102_-|NAD(P)H-hydrate-epimerase	unknown	unknown	gnl|CDD|223140

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_152022068.1|8094796_8095549_-|PEP-CTERM-sorting-domain-containing-protein	gnl|CDD|379155	pfam13385, Laminin_G_3, Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	4.46532e-19
NZ_AP019860.1|WP_151971370.1|8088185_8089250_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	2.86295e-44
NZ_AP019860.1|WP_151971375.1|8095837_8096938_+|methylated-DNA--[protein]-cysteine-S-methyltransferase	gnl|CDD|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	3.3632e-56
NZ_AP019860.1|WP_151971373.1|8091877_8092567_-|response-regulator	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.68347e-92
NZ_AP019860.1|WP_151971383.1|8106107_8107550_-|HAD-IG-family-5'-nucleotidase	gnl|CDD|377556	pfam05761, 5_nucleotid, 5' nucleotidase family. This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.	0
NZ_AP019860.1|WP_151971371.1|8089228_8091151_-|NAD(+)-synthase	gnl|CDD|235057	PRK02628, nadE, NAD synthetase; Reviewed.	0
NZ_AP019860.1|WP_151971380.1|8102682_8104521_-|N-acetylmuramoyl-L-alanine-amidase	gnl|CDD|133475	cd06583, PGRP, Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conserved histidines and a cysteine are zinc binding residues. Site-directed mutagenesis of T7 lysozyme indicates that two conserved residues, a Tyr and a Lys, are important for amidase activity.	7.36185e-32
NZ_AP019860.1|WP_151971378.1|8099472_8101200_-|thiamine-pyrophosphate-binding-protein	gnl|CDD|235629	PRK05858, PRK05858, acetolactate synthase.	4.80907e-111
NZ_AP019860.1|WP_151971381.1|8104551_8105421_-|hydroxyacid-dehydrogenase	gnl|CDD|240628	cd05303, PGDH_2, Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains. Phosphoglycerate dehydrogenase (PGDH) catalyzes the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDH comes in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases. PGDH in E. coli and Mycobacterium tuberculosis form tetramers, with subunits containing a Rossmann-fold NAD binding domain. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	2.27398e-115
NZ_AP019860.1|WP_151971376.1|8096934_8097834_-|FkbM-family-methyltransferase	gnl|CDD|273628	TIGR01444, 2-O-methyltransferase_NoeI, methyltransferase, FkbM family. Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.	6.08431e-32
NZ_AP019860.1|WP_173013627.1|8087431_8088175_+|metallophosphoesterase	gnl|CDD|277317	cd00838, MPP_superfamily, metallophosphatase superfamily, metallophosphatase domain. Metallophosphatases (MPPs), also known as metallophosphoesterases, phosphodiesterases (PDEs), binuclear metallophosphoesterases, and dimetal-containing phosphoesterases (DMPs), represent a diverse superfamily of enzymes with a conserved domain containing an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. This superfamily includes: the phosphoprotein phosphatases (PPPs), Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	6.61301e-06
NZ_AP019860.1|WP_152022067.1|8084287_8086093_+|VC_2705-family-sodium/solute-symporter	gnl|CDD|274698	TIGR03648, Na_symport_lg, probable sodium:solute symporter, VC_2705 subfamily. This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.	0
NZ_AP019860.1|WP_151971379.1|8101500_8102604_+|hypothetical-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	6.85566e-10
NZ_AP019860.1|WP_151971372.1|8091143_8091869_-|UDP-2,3-diacylglucosamine-diphosphatase	gnl|CDD|235420	PRK05340, PRK05340, UDP-2,3-diacylglucosamine hydrolase; Provisional.	1.22394e-41
NZ_AP019860.1|WP_173013628.1|8092636_8093545_-|EamA-family-transporter-RarD	gnl|CDD|225510	COG2962, RarD, Predicted permeases [General function prediction only].	1.37269e-92
NZ_AP019860.1|WP_173013630.1|8097977_8099429_+|PLP-dependent-aminotransferase-family-protein	gnl|CDD|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.24178e-145
NZ_AP019860.1|WP_151971382.1|8105430_8106102_-|NAD(P)H-hydrate-epimerase	gnl|CDD|223140	COG0062, COG0062, Uncharacterized conserved protein [Function unknown].	7.71989e-54

Protein sequences

>NZ_AP019860.1|WP_152022068.1|8094796_8095549_-|PEP-CTERM-sorting-domain-containing-protein
MKKIYFILISIILSSVIAAAPITTDGLIAFYDADDNTANDQSGNGGPNGTLNGVSISPNGAFNQGFSFDGNSSIDLGNNSIIGSDTSFSIVAWVNANSFGAQTAIYGEFNTNNIDTRNYLFLDSSGRVFFDQFPNSGGALVSQNSIATGQFSQIVYTQDGTTRRIYIDGVLEAEDTSIETYQGSVPDVARIGFRDNQNFGFDGVLDEIAFYDRALSIEQVTSQFAAVPEPSTYIAFLFGLFAIGYFRKRK
>NZ_AP019860.1|WP_173013629.1|8093525_8093678_+|hypothetical-protein
MTNIYPTIYSTNKYHNRHNRNSNNRNRNRHRSRSRNRHRDLDRDHDRQCH
>NZ_AP019860.1|WP_173013628.1|8092636_8093545_-|EamA-family-transporter-RarD
MGYIFVICAYFLWGILPLFWKQLAHVPAAEIIFHRMLWSFVSMGVLLTALRNWKWIALLRESPKMLLWGFLSAALIAGNWFIFIWAVNNGYIVEASLGYFINPLLSIALGIIVLKEGVRRVQIFAIIVAALGVCYLTFVYGHFPVVAFVLAATFGIYGLIRKMIPFGALSGLFVETAFMFLPAVFCLVHLESSGNGTFSDSSFSTQALLLITGVATITPLLFFAAGVRKIPLYTVGFLHYIAPTLQFLIGVFVYNEKFSFSQLVGFCFIWLAIVIFCVESYVFYKNNKAVMVGLSPATDDSA
>NZ_AP019860.1|WP_151971373.1|8091877_8092567_-|response-regulator
METILVVEDDPAILLGLTKNLQFEGFNVLCAEDGEEALEIIFNKPIDLLLLDVMLPKLNGFEVCKTVRKKNLGVPIIMLTAKDKEIDKIMGLDLGADDYIAKPFSVRELIARINAVLRRKRKYEDKANDVLLFGNIKVNFQGRTVHKDDERVDLSPKEFDVLKLLVQNKGKVLSREEILNKVWGYDYFGTARTVDNFINKLRQKIEEEVTQPLYILTVRGIGYKFQIPE
>NZ_AP019860.1|WP_151971372.1|8091143_8091869_-|UDP-2,3-diacylglucosamine-diphosphatase
MKKVIFVADLHIDIGETKRLQAFEKFLATEQAPIYIMGDLFNFWAGNAQGNLGYVRHFLRFLRRICAKKQIFFLAGNRDFLFVPFFAKRLKGNTIEDGYTLTLGKHRVVLYHGDALCTGDKSYLEMKKWLQSDLIYYISRFMPSNVCVKIGQKFRQTSQKAIRKKAQKDMGLNFQFILDILDDLNQDVMICGHTHKPQFKVLREEKDNDKELYVLPECKEQCISYLEWSDNQFTYKEKNYD
>NZ_AP019860.1|WP_151971371.1|8089228_8091151_-|NAD(+)-synthase
MTNQPYGFIRTAAASPKLKVADITYNTQQIIQTIHEAHAQKCQIVVFPELCITGYTCGDLFYQDLLIAKSRQAVNIIAQQTKDLDMFIVLGLPVLVQSKLFNCAVAVLGGEVLGVVPKTHLPNTNEFYEKRWFCSANDNVYDTVYWEDKAVPFGTDLLFCATNFRECIIGMEICEDLWAVAPPSGDMAINGATIICNGSASNEYIEKVDFRKSLVAMQSARCLCTYLYASCGPGESSTDLVYSGHSMIAEAGAIVKESARFRSEGSITVADVDLQKIVCQRLKNSTFFTSNSPKKRRRVAFSFATITNPQTLERPLSRFPFIPADNKEDAYYEILELQSIALAKRVEHIGRCKLVIGVSGGLDSTLALIVCAKAFKRLNRDPKDIVAITMPGMGTTTQTKGNAERLSESLQVTLRTIAIEKAVMQHFADIDHDPQQHNITYENAQARERTQILMDVANQVGGFVVGTGDLSELALGWCTYNADHMSMYSVNVGIPKTLIQHLIRWYATTVDDTLKEILEDIANTPISPELLPHDNDEIQQKTEDKVGPYILHDFFLYHHLYFQFSPQKIFYLAEQTFREEYRSEEIRKWIQIFYKRFFQQQFKRSCLPDGPKVLAVSLSPRGDWRMPSDAVGNLWLEDCL
>NZ_AP019860.1|WP_151971370.1|8088185_8089250_-|leucine-rich-repeat-domain-containing-protein
MAGGLLVGISNKRKAQVIEKTLVSRQTLKEVKSNSHYAGCTFYLDDNYSIENTSFDNCSFRSDAIFGNLPDCTFENCNFSATFVLHLSGRYLSAIPEYVFSLRDLTHLLVFSNNISCIPDEIGNLQNLEYLDADHNQIESVSREIQQLRKLSMLHLSGNKIGRLPMQIGQLQNLRYLSLSHNTIDKIPCEIGHLTALTLLDISHNSIKSIPEQSERLQSLNLLSLYGNNITNVPKEIWEKYPQEHKESGGRPVFNKYHNENVKSGALPPEVGELQNLVELHLSGNYICEIPNEIGMLRNLNELHLAYNEISSIPSEIGQLQNLRELWLNNNEIEELPKGIAKLENLKQLHLPTD
>NZ_AP019860.1|WP_173013627.1|8087431_8088175_+|metallophosphoesterase
MIAIIASIHGNLQALQAVIEDIDKRNIKTIYCLGDMVGYGPNPRECIEIVRDRCEFCLRGDFEENIMRQSLSSTPGVLEITIEWIRNQLYSESYPETQNNELWDVIANAKQKVYRDRCLYAHNASPNNGYAVPLSFIQLKYTMSHFSNYNVFFCGGSHVPGVFTEEYQYHYAADINNLFYLSPTSKQIIDVGSVGKPQDRNNHACYAILNDQTLQWIRVEYDINKTIEEIENCTLPNTIADYLRREI
>NZ_AP019860.1|WP_151971368.1|8086115_8086949_+|hypothetical-protein
MNKLFILLLFTTVYAQTTHDIVAHTFSVLKQQHIFRNHKQQDKEPRPLYLAQQAFTEAKQADKEVQMRDRLNIALAHANQARFLHSASLNSLQIQKRRGWRNGLDTVTFGISSIFLESNEEKYSEDGKVISSAAYRYLLAVYIARQAQKALKEKPAQVKHEIKWEKILQRKMLFAKAKKVDQLTITQFKTLTSELFYRSLTMAIRSLKKSNKTSLINQYIDYLAKLAPQQKKVWLQRKDIVARVLKLSGAPSDLEYERDARTILNCEDALRILSEFD
>NZ_AP019860.1|WP_152022067.1|8084287_8086093_+|VC_2705-family-sodium/solute-symporter
MELQTLTYWVVGLSFALYIGIAIWSRASSTSEFYVAGKHVHPIANGMATAADWMSAASFISMAGLIAFLGYEGGMYLMGWTGGYVLLATLLAPYLRKFGKFTVPEFIGDRYYSQLARVVAVVCLIFISFTYVAGQMRGVGIVFSRFLEVSIDSGLFIGMGIVFIYAVLGGMKGITYTQVAQYCVLIFAYTVPAIFIALQTTGSALPQIALGAEVLDGSGTLLAKLDQSLTDLGFGAYTTPFNDKSMIDVFAITLALMVGTAGLPHVIVRFFTVPKVRDARTSAGWALVFIAILYTTAPAVGALARTNMIQTVNGTEQQGTAYKEIPEWFKTWEDAGLIAWYDHNNDGRVQYAAGNAFTGKPEFDGDKRGKHGERIVKNPSEGKTAKNAPFANEIYVDRDIMVLANPEIAGLPNWVIALIAAGGIAAALSTAAGLLLVISVSVSHDLLKSTFTPQISEKNELLAGRIAAGVAIGIAGYLGLHPPAFVAQVVAFAFGLAASSLFPVILLGIFSKRMNKWGAISGMLSGLIFTMGYIIYFKGVFISPIAANVPENWLLGISPEGIGSIGMVINFAVAFTVSHFTSPPPAEVQELVEDIRVPQNS
>NZ_AP019860.1|WP_151971375.1|8095837_8096938_+|methylated-DNA--[protein]-cysteine-S-methyltransferase
MPHYLFDTNIGKVVLSWQDDQLKGVALATRGLHITKSKTPTWVKDIAKKIRQHLQGKYCDFDDLPLDLSSFTEFQKMVYRGCQDIGVGETLSYGELAKVIGRPRAARAVGTALKKNLFPIVIPCHRVLAAGRKLGGFSAPGSTCTKYRLLQIEKAKVANVDEEIVRWDEGVKMLGKKDKKLKNAMQKIGTFHLEKSSAHSLFESLAMSIVFQQLATAAARAIWRRFCELFPRNIPTPKQVMRCDEETLRGAGLSRNKMLAIRDLAQKTLQGDIINDDAKLTAMTDAEIIESLTQVRGIGRWTVQMLLIFYLRRLDVFPEDDYGIRKGFAILYDLAELPTPKEMRNAAQEWQPYRSIASWYLWRLTD
>NZ_AP019860.1|WP_151971376.1|8096934_8097834_-|FkbM-family-methyltransferase
MLKNSSTFKIIIKKILCFAPVNKLLQWILRPFISFLPQDLSRIPVIGTVKFSCDRDTLLMRGCGNDTIATALFWRGMAGFEPHTMEVFKKLLRHSNVFLDIGANTGIYSLIAAKKGVVVHAFEAVPDIFHKSLLPNLALNEMDEVHTHCCAISDEPSGFIELYIPHSTAIPTSASTVAGFKENCKCVQVPQTTIDHFVANQSLDTVDLLKIDVEGAELKVLNGCKDTLLNHKPFVICEVLPGKEQGIQSFFSTAQYAFFHITTQGLVEKDVVEASSEHLNYLFVSHKRLDEFRGIFDNL
>NZ_AP019860.1|WP_173013630.1|8097977_8099429_+|PLP-dependent-aminotransferase-family-protein
MKSNIPESFSFDISRSTVPLYRQIYEQLKTAILSQQLAPGTKLPASRELATRLQVSRNTVTNAYEKLWSEGFVEGQIGAGTYVAHIDFTTLQTTNFNEKNDQRPLLSQRGEKIFACAKKDYIAKPETFTPGIPDIKAFRKDVWARILSRQARYHIEDLFAYDSPAGYAPLRTVVCQYLRAYRGVKCDTEQVVIISGAQQGLDLIARFLIDPHENVAMENPGYLGARNAFFAAQAQIIPVDVDAAGLKIDDLQRQRDVRLLYLTPSHQYPLGMTLSLERRIQILQWARQQNAWIIEDDYDSEYRYAGQPIAAMQGIDNSDRVLYLGTFSKVLFPGLRIGYMVVPKALVPVFSLAKSICDHNCSTLLQAALASFIEAGHFNSHLRRTRILYKEKQQYFLQVFAHKLSKYCTIEPSATGMHLVAFYNGDDREITKEAVRHNLVLRPLSSYYLQNPRSGFVLGYAGYTLPQIYEGICTLEKIFTRKN
>NZ_AP019860.1|WP_151971378.1|8099472_8101200_-|thiamine-pyrophosphate-binding-protein
MDYAGNLIASFLHRQGVQFLFTLCGGHISPILVGAKQKGIRVVDVRDEVTAVFAADAVARLTGIPGVAAVTAGPGLTNTITAVKNAQMAQSPVVIFGGATATMLKGRGSLQDIDQMALMKPHTKLALTVKSVREILPKLEKAFVTCQEGIPGPVFIEIPVDLLYAESVVRDWYGIKEEKGKNIRASLFQAYLKRHVKKIFSGVNWQPSFRELKVASFAPRKKDIDAMVRCIHQAQRPVMLVGSQATLHPQNANALQQAIVKLGIPTYLSGMARGLLGKQCPLQLRHRRRQALKESDLVILVGVPCDFRMNYGRHIPAQAKYISINRSAKDLRKNRVPDLGVLCDPGNFLLELARFCENNSFAEGWLQSLKQRDAQRDEEISHQGQEETTGVNPLHLFQHLEKLMSEKSIIVADGGDFVATASYILRPQPLSWLDPGAFGTLGVGAGFALGAKLCRPDAEVWIVYGDGSVGYSLCEWDTFVRHNVPVIAVVGNDACWSQIAREQVQIFADDVGTVLEHSSYEKVVAGFGAEGLLLDQANKIPDIVKEAQEKCAAGKPVLINAIIGKTDFRKGSISI
>NZ_AP019860.1|WP_151971379.1|8101500_8102604_+|hypothetical-protein
MITLVKINCSYFEQACVQTIIGILGTLDKFYNKKTIIVDLSPEGLTTLAFGISSLSRKNNIIDVVSGKVHYEDAIFCQNNSNFCILPYGYYVEDWYPDEDNFLLLDEVLQKLNSTFDFVFVYDSSLNCFFYPHILEMVDNALFPTNATYSQAIVSVLQGMREFKEHNAKIREKKHILGVVGHYEKMDQIVKEVFRYWEEKRVKLFKPIIEVTREFTESIGLGEFIWDYAPDCKSIKDYRELSQDFLNTCSRKIVRSKVLEDVDDGTNYYGCTFFLPETKFYQVLCSRFEHCSFRSKIQFHSLRGCEFVNCGFSDEFLLDLSDLNLTRLPWYIYTIRDLKTLDISGNSLGDQSMRLLLEHLPDCRIIR
>NZ_AP019860.1|WP_151971380.1|8102682_8104521_-|N-acetylmuramoyl-L-alanine-amidase
MRQIIFVLLCITFTCAHMDLQYTDRFTAEHMNQCSCENVTLLENFMVLDENEGKLTSVDIKARTYFNAISINYYAEIPEGAALRFEVSAGDNNGNWSAWHEVESSEADVHFDGSYDTYRYRVVFVRSEDGHSPQLREVQVSYDYVIPSMLQPEVYVQQQSRGVLKPSIVSRRDWGARQPKKGYSYHSPRKLTIHHTYRPLASSFKGASTIRGIQNYHMDSNGWSDIGYHFLIGTYSSGSTVIYQGRPENVIGAHTGGANTNNVGVNLIGDYDIEQVHPNGYKAMIRVLAWLCDKYGISPNSIYGHKDFSSTLCPGSGLYDRLPQIRRDVANYIVRGEVQEDVNAQASGTLIGAVYDSNKGSSARISGATVTLNNGSKQTTGSDGIFRFQLSPGSYSYTVSKSGFKSNSSSRTVKSGETVWGSLGLSGGSGSPSKSLSGAHWVKFYPPSRQIKDLNEPFRGSMTRFYNALRNAGASVSISNTLRPPQRAFLMHWAYRIAKEGYNPRSVPAKSGVNIEWWHGSTSASVSAARAMVSAYGIVYRPALSSNHIRGEAIDMSVSWSGTLRIKDANGRTVSIGSPRSGASNRTLWEVGKTYGVRKLASDPPHWSRNGN
>NZ_AP019860.1|WP_151971381.1|8104551_8105421_-|hydroxyacid-dehydrogenase
MKILICDAFDSSLPEKLAAYGEVFSDIERLAEANIALIRSKTKCTKEWIDKAPELKMIIRGGVGLDNVDCDYAQQKGIRVDNTPEASSIAVAEMAFAMMIAMPNQIIKAHNGMKAGEWLKKQCKRTELHGKTLGLIGYGRIAKELAKRAQAFSMKVIAYKRTPVDCEYAEMKSLDELLSQSDFISLHTPLNDASKNLINSETIAKMKQGVYVINTARGQCVAEKDVAAALESGHIAGYAADVWEVEPPEDRTLVETKNCFASPHIASSSAENLKRIGEIVEQKISAFVS
>NZ_AP019860.1|WP_151971382.1|8105430_8106102_-|NAD(P)H-hydrate-epimerase
MKAYSKEQIRELDRIAIEEYQIPSVVLMENAGAGAARIIAREMGAQKSVAIFCGKGNNGGDGFVIARHLHNNGMNTHVFFLGEAAQVPVDSDPGINLRILQNMKIPIREVSDVDSLKEYKDIWQNCDYVVDAIFGTGLCRDISGNLHTIMSEIKSWNKKNIAIDIPSGLDGNTGEIYGVILPAELTITFALPKKGFFVQDGPNVTGNIEVVDISIPKELVEKL
>NZ_AP019860.1|WP_151971383.1|8106107_8107550_-|HAD-IG-family-5'-nucleotidase
MIKIPYTRGIFCNRTLNLRAIPVIGYDMDYTLVHYKVEAWEGLAYQYIKKYLKKDGWPVDDLVFDPSIFIRGLLIDKELGNIVKVNRFGYVKAAYHGTHRLEFEKMREVYSRTIVDLADTRYAFLNTLFSISEACMFSQLVDLLDAGKITGILGYADLAHRIRTVLDHAHLEGDLKNEIMAHPEKFVELDPDLPLTLLDQRHANKKLLLITNSGWKYSKFMMSYICDRYLPKGMDWRDLFDLIVVSARKPSFFTAKPPMFEIVDNDDGLLKPVIGEIKKNGCYLGGNASMIEEYLGVSGEQILYVGDHLFCDVSISKEVLRWRTALIIRELEEELEAIESARKDHKQIRKMMQEKEELEGQIRHKQLILQRREKKYAGKVKENPTDIKSELRQLRDDLHELDVQIGELNVRDSKRFNSNWSYLMRTGNDKSKFTRQVERYADIYTSRVSNMLYYTPFMYFRSPRGSIPHDPVFYPEDLKE
>NZ_AP019860.1|WP_151971384.1|8107666_8108509_-|hypothetical-protein
MKCAFLTSRDLPNLIAEELAVVELLRKKNITIDVVVWNDKVDWSIYNCVVIRTTWDYYLHSEKFLDVLQEIQRCGCRLFNSFEIAKWNTNKRYLLELEQKQVAVIPTKIVQNVREENWQEHFTRWDTQKLVVKPVISAGAYHTYVIDHKEAPQIPSIDVSYMVQPFLPSVAEEGEWSFMFFGGQYSHAVIKRPKQNDFRVQEEHGGSTELMEVEHDDLLEAKKVIAAIPKQLYARVDMIRYRGKLHLIELELIEPQLFLANCTKGVEMFAETFCQMCDDK

Crispr_ID: NZ_AP019860_42

• CRISPR_ID: NZ_AP019860_42
• CRISPR_location: 8488008-8488096
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_42

Consensus_repeat	Method
TTTTAGCTTCGACAAAAGGAATTCGTTTT	CRISPRCasFinder

spacers of NZ_AP019860_42

>42.1|8488037|31|NZ_AP019860|CRISPRCasFinder
TATATTGGTGCTCTCACCATCGAATTTAAGT

CRISPR arrays and Neighbor proteins around NZ_AP019860_42

CRISPR arrays

The CRISPR arrays of NZ_AP019860_42

>merge|NZ_AP019860|42|8488008-8488096|CRISPRCasFinder
TTTTAGCTTCGACAAAAGGAATTCGTTTTTATATTGGTGCTCTCACCATCGAATTTAAGTTTTTAGCTTCGAGAAAAGGAATTCGTTTT

>NZ_AP019860|42|35|8488008-8488096|CRISPRCasFinder
TTTTAGCTTCGACAAAAGGAATTCGTTTT	TATATTGGTGCTCTCACCATCGAATTTAAGT
TTTTAGCTTCGAGAAAAGGAATTCGTTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151971639.1|8491725_8493537_-|hypothetical-protein	unknown	unknown	gnl|CDD|274173
NZ_AP019860.1|WP_151971631.1|8481692_8482241_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971643.1|8497962_8498439_+|phasin-family-protein	unknown	unknown	gnl|CDD|377530
NZ_AP019860.1|WP_151971635.1|8486412_8486853_-|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl|CDD|377815
NZ_AP019860.1|WP_151971636.1|8488513_8489380_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_AP019860.1|WP_151971640.1|8493983_8495594_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971633.1|8483722_8484919_+|DUF1501-domain-containing-protein	unknown	unknown	gnl|CDD|226587
NZ_AP019860.1|WP_151971645.1|8499543_8500965_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_152022076.1|8486849_8487836_-|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|225722
NZ_AP019860.1|WP_151971637.1|8489384_8489906_-|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl|CDD|223799
NZ_AP019860.1|WP_151971634.1|8484915_8486409_-|tripartite-tricarboxylate-transporter-permease	unknown	unknown	gnl|CDD|225870
NZ_AP019860.1|WP_151971641.1|8495590_8496271_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971629.1|8479242_8480043_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224046
NZ_AP019860.1|WP_151971642.1|8496274_8497324_-|type-IV-pilus-assembly-protein-PilM	unknown	unknown	gnl|CDD|378558
NZ_AP019860.1|WP_173013654.1|8482233_8483718_+|DUF1800-domain-containing-protein	unknown	unknown	gnl|CDD|378055
NZ_AP019860.1|WP_151971627.1|8476608_8477916_-|metal-ABC-transporter-permease	unknown	unknown	gnl|CDD|224033
NZ_AP019860.1|WP_151971630.1|8480047_8480962_-|zinc-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238498
NZ_AP019860.1|WP_151971628.1|8477912_8479259_-|metal-ABC-transporter-permease	unknown	unknown	gnl|CDD|334323
NZ_AP019860.1|WP_151971644.1|8498613_8499144_+|dCTP-deaminase	unknown	unknown	gnl|CDD|274062
NZ_AP019860.1|WP_151971638.1|8489977_8491519_-|Rne/Rng-family-ribonuclease	unknown	unknown	gnl|CDD|273254

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151971639.1|8491725_8493537_-|hypothetical-protein	gnl|CDD|274173	TIGR02515, Putative_DNA_transport_protein_HofQ, type IV pilus secretin (or competence protein) PilQ. A number of proteins homologous to PilQ are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). Members of this family include PilQ itself, which is a component of the type IV pilus structure, from a number of species. In Haemophilus influenzae, the member of this family is associated with competence for transformation with exogenous DNA rather than with formation of a type IV pilus; the surface structure required for competence may be considered an unusual, incomplete type IV pilus structure. [Cell envelope, Surface structures].	2.74987e-52
NZ_AP019860.1|WP_151971643.1|8497962_8498439_+|phasin-family-protein	gnl|CDD|377530	pfam05597, Phasin, Poly(hydroxyalcanoate) granule associated protein (phasin). Polyhydroxyalkanoates (PHAs) are storage polyesters synthesized by various bacteria as intracellular carbon and energy reserve material. PHAs are accumulated as water-insoluble inclusions within the cells. This family consists of the phasins PhaF and PhaI which act as a transcriptional regulator of PHA biosynthesis genes. PhaF has been proposed to repress expression of the phaC1 gene and the phaIF operon.	5.73858e-06
NZ_AP019860.1|WP_151971635.1|8486412_8486853_-|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl|CDD|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	1.37145e-08
NZ_AP019860.1|WP_151971636.1|8488513_8489380_+|alpha/beta-fold-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.12847e-40
NZ_AP019860.1|WP_151971633.1|8483722_8484919_+|DUF1501-domain-containing-protein	gnl|CDD|226587	COG4102, COG4102, Uncharacterized protein conserved in bacteria [Function unknown].	2.95511e-58
NZ_AP019860.1|WP_152022076.1|8486849_8487836_-|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl|CDD|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	1.38394e-82
NZ_AP019860.1|WP_151971637.1|8489384_8489906_-|YkgJ-family-cysteine-cluster-protein	gnl|CDD|223799	COG0727, COG0727, Predicted Fe-S-cluster oxidoreductase [General function prediction only].	1.19996e-05
NZ_AP019860.1|WP_151971634.1|8484915_8486409_-|tripartite-tricarboxylate-transporter-permease	gnl|CDD|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
NZ_AP019860.1|WP_151971629.1|8479242_8480043_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224046	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism].	1.56314e-115
NZ_AP019860.1|WP_151971642.1|8496274_8497324_-|type-IV-pilus-assembly-protein-PilM	gnl|CDD|378558	pfam11104, PilM_2, Type IV pilus assembly protein PilM;. The type IV pilus assembly protein PilM is required for competency and pilus biogenesis. It binds to PilN and ATP.	3.93635e-59
NZ_AP019860.1|WP_173013654.1|8482233_8483718_+|DUF1800-domain-containing-protein	gnl|CDD|378055	pfam08811, DUF1800, Protein of unknown function (DUF1800). This is a family of large bacterial proteins of unknown function.	4.93192e-159
NZ_AP019860.1|WP_151971627.1|8476608_8477916_-|metal-ABC-transporter-permease	gnl|CDD|224033	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism].	4.7696e-62
NZ_AP019860.1|WP_151971630.1|8480047_8480962_-|zinc-ABC-transporter-substrate-binding-protein	gnl|CDD|238498	cd01016, TroA, Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).	1.90461e-127
NZ_AP019860.1|WP_151971628.1|8477912_8479259_-|metal-ABC-transporter-permease	gnl|CDD|334323	pfam00950, ABC-3, ABC 3 transport family.	7.53176e-72
NZ_AP019860.1|WP_151971644.1|8498613_8499144_+|dCTP-deaminase	gnl|CDD|274062	TIGR02274, Probable_deoxycytidine_triphosphate_deaminase, deoxycytidine triphosphate deaminase. Members of this family include the Escherichia coli monofunctional deoxycytidine triphosphate deaminase (dCTP deaminase) and a Methanocaldococcus jannaschii bifunctional dCTP deaminase (3.5.4.13)/dUTP diphosphatase (EC 3.6.1.23), which has the EC number 3.5.4.30 for the overall operation. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	6.93806e-47
NZ_AP019860.1|WP_151971638.1|8489977_8491519_-|Rne/Rng-family-ribonuclease	gnl|CDD|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	3.24572e-167

Protein sequences

>NZ_AP019860.1|WP_152022076.1|8486849_8487836_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MPFLIILTAACFFLSIRKSPQNLHSDSIQQIHFLVPGGVGGGWDTTARTVGEVLRKAKLVPQISYENLSGGGGGKAIAHVIETAKHQQQTLMVNSTPIVIRSLQKVFPQSFRDLTPIASIIGDYSCLVVTKDSKYNNWSQIVAEYRQKPSKISIAGGSVKGGMDHLVAAMICEACEIELSDLVYIPYDAGGKALAGLISGETQLLSTGLGEAMELAKAGQLKIIAVTAPNRVKAISDIPTFRELGYDVVFANWRGFFAPPGIHEKQRKLYDKLFRKMYDEVLWKEARKKNGWSEIYYANDEFTQFLQRQEQQLQKLMTKLGFIKETQK
>NZ_AP019860.1|WP_151971635.1|8486412_8486853_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MNEQRVGGVIFFVFCALYLFFATDITVTSESTFSARTFPYILGVMGCIVSLLLIVLPSIQKTIALTQLKWSAVFAMCLAMLVYAFLLSRIGFIIATILFLNTCFIIMRERKWRHMFYTSFSLTCIFWLLLTQVLNIYLAPGSWWMG
>NZ_AP019860.1|WP_151971634.1|8484915_8486409_-|tripartite-tricarboxylate-transporter-permease
MWDGILIGISTAFSPVNLIAVMLGCFAGTFIGLLPGLGPISAIALMIPITYGLDPATGMILMAGVYYGAIFGGSTSSILINAPGVAGTVASSFDGYPLAKSGNAGKALALAAYSSFIGGTVATFLLLLFAPLLAKVSLSFQSSDYFMLMVLGLTTVAAFSGKGNYLKAGIMTIFGLMLSTVGTDLSTGVERYTFGSIDLLDGISFLLLAMASFALAEALHNILVPVKESDTSSTEVSDLSISKQEFGEVAPTIGRSSILGFFVGILPGAGATIASFLAYGVERNLASEEQKQKFGKGSLRGLAAPETANNAACSGSFVPLLTLGIPGSGTTAIMLGALISYGVQPGPRLFVDHPQVFWSVIISMYIGNMVLLIMNLPLIPYIAKLLTVPRPILIPLILFFSLIGVYLVSFNTTDLYIMVFIAIFALLLRLLQFPIAPMLLGFILGKPIEDNLYRALLANNGSVSFLWERPITLAIFCLVCAVVILPCWRIYRKRSSD
>NZ_AP019860.1|WP_151971633.1|8483722_8484919_+|DUF1501-domain-containing-protein
MDILRQGFLRKLLFAKNKEQSTTLVCVFLRGGADTLNFVVPYGDDDYYRLRPSIHIAAPKNNKRESSIRLDDFYAFHPKLSPLYPLFEEGRLGIVQAVGSDNTSGSHFEAQDQMEHGSSQHQLLGSGWLGRHLRLHNNEHKKAISAVAMGTTIPESLRGAPNINVIQSLSDLKIHTASGNSQSARDAIAKMYGIQSNILNQHGQDTLGLLQKIENLQKSEYRPENNANYPQNSFGNELREVARLIKGQLGLQVACIDLGGWDTHFFQGQENGLQAGNIDTLAKGLAAFDADLHRYKNSVTTVVMTEFGRRVYENSSMGTDHGRAFTFFALGNKINGGQVLGKWPGLKNDNDEEGPGGLKVQYDYRSLLSEILLDVLNNRQIAKIFPNFRPQKIGLTKR
>NZ_AP019860.1|WP_173013654.1|8482233_8483718_+|DUF1800-domain-containing-protein
MNRRDFVKVMAGTLSLCGCNDMISAVSKQFGQGIPKTLTPAQQSTLDKDFHFLSRTTYGLWPGDLEKVKNMGRKAWLEKQLQPQNINDTLCDLRARRFETIHHHFSTCYEYKKKTLRSEMVKHTLLRAIYSRRQLFEVMVGFWSDHFNIHIEKADCIYLKATDDREVIRKHALGNFRDLIRASAISPAMLVYLDGKSNKKQKPQDIPNENYARELLELHTLGVYGGYTQKDVFEVARALTGWRYHRRKRDVFFNVHLHDQGQKTILGHTLPANGGKEDLERVLDIVCNHPSTASYICYKLAKRFVAPKPPKQLVTNMSKVFSDTKGDIKAVLRYLFLSEEFYNPTFFAQKFKRPFHFIVSSLRFLAADTYARRPQINYLERMGQVPFQYPTPDGYPDEMQPWLGTLLWRWNFAHAVAANKVSGTRIHLRKLLKSLNINDKEQVTKVIAHFIGRLPTPQEQQIFAEYMNDKDMKKATNQQELLGLILCSPAFQRY
>NZ_AP019860.1|WP_151971631.1|8481692_8482241_+|hypothetical-protein
MIMADVLAITMFIIGLLLSLNALLLFCRGIWLDTTNDISELCSQGLKKNFFYGLIPSVGTVFFALVIGENAKKMGKILGPTILSLFFLYSCIGLSGFVTMIGQRLIADKNSLWKTTVAGGASFSLACLLPILGWFILFPAGLIIGCGAKMRARSYRKQRSLQNAKTQENANTEQNSQEESDE
>NZ_AP019860.1|WP_151971630.1|8480047_8480962_-|zinc-ABC-transporter-substrate-binding-protein
MTKYMISLLLILLVIPCYADRDKLYVVSTTGMIADALENVGGDLITVDSLMGPGVDPHLYKATANDTKKLARADIIFYNGLHLEGKMQKILMTMSRRKIVCAITNGIPESKLIKPEGFDGLHDPHIWFNVSLWQEAVKKITGVLCGVDQKNAQAYQKNSEAYIKKLQTLHSWAQQQINLIPQKSRVLITAHDAFGYMGKAYGFEVMGLQGVSTVTESGIKDIERIVQVIVSRNIKAIFEETSVMNKGVEAVIEHCKELGHEVKMGGSLFSDAMGEPGTIEGTYVGMVEHNVKTIVRALSSTDKE
>NZ_AP019860.1|WP_151971629.1|8479242_8480043_-|ATP-binding-cassette-domain-containing-protein
MGRESKKVDEETVADVHDLTVSYHIHPVLWDVDFQVPRGKLMAIVGPNGAGKSTLIKAMLGIIPSTTGWVKIFNEPYQKVRHRIGYVPQRGSVDWDFPTTAIDVVTMGRYGKIGWFRRPGKKDREISYTYLEKVGMQDFAQRQISQLSGGQQQRVFLARALAQEADIYFMDEPFAGVDVVTEKAIVNLLFELREQSKTVIVVHHDLQTVNEYFDWILLLNMRKIAIGNVDDTFNEENLRKTYGGKLAILSKAANAMTKGRVDGIID
>NZ_AP019860.1|WP_151971628.1|8477912_8479259_-|metal-ABC-transporter-permease
MELLTSNWWLFDEIGKYFLPEGSTRRWVMFGAILLGISSGVIGSFALLRKQSLLSDAMAHAALPGICLIYMLTGVKDPLLFLVGASITGLLGAIIVSEIPRHTRIKSDTAIGLVLSVFFAFGIVLLTVIQKNFGGNQAGLDAFLFGKAALLVRYDLYVIGTMCLLLIGITLLFYKEFKLLTFDRGFAITLGLPAKKLELCMTLLIVLAVMVGLQAVGVVLMVAMLIFPAAAARQWTDQLGRMIIIAAFVGGFAGVVGSFCSAIMSKVPTGPVMVVVCSTMLIFSMFFAPNRGLIPKWLRLRNNRQRIRRENILKSCYKTCEERENWKVIFTLKDFTTYFRFSNYATRQLLHYLVKKQRLVSFNGGWQLTPQGLDKAEQIIRKHRLWEVYLTEKMDIASDHVHRDAEDIEHALDDKTVQQLEEELQSPTQDPHGKSIPNVDFSRERKTT
>NZ_AP019860.1|WP_151971627.1|8476608_8477916_-|metal-ABC-transporter-permease
MTLMAFASFEIWIMVIGALVCSACGILGCFLILKKLALMGDAISHAVLPGIVVAVMLSGSLNSIAIFVGAGIIGVLTPILVDSLKSSRLIDEDAAIGSVFTFLFAIGVIMVANAGNIDLDTECVLYGEIATTPFDTWVVGGTPYEFDGHTFMKGGTDIGPKSAWTLGIVLLINILFIFFFYKELKISTFDPALALSMGLKPKLIHYLLMFFVAITTIASFEAVGAIIVVAMFIAPGASAYLLTDRLSLMIFLSGIVGAASSVLGYMLALALGGDVSIAGCMAVAAGGIFAMCFFFSPKYGVVVRFARRYKLKKRFHAENALVNMYRTHELGERCLVKNYRHNVIVRFIQQNILTEKDGELHLTEFGTEKAQNLMRAHRLWEAYIHKLGLPEDHVHQPADEMEHYLTNDLCTEIAQELKNPQSDPHGKPIPTKPAL
>NZ_AP019860.1|WP_151971636.1|8488513_8489380_+|alpha/beta-fold-hydrolase
MQLQHKQIQANGVKLHVVEGGNENGDAIIFLHGFPDFWYGWQKQIAYFVEKGYRVIAPDQRGYNLSDKPRGVRNYHLDTLTSDIVALMDNLHIDQAYVVGHDWGGGIAWWLATNYPQRVKKLVICNMPHLVVLRNYLLSSVRQMCRSWYMLAFQVPFLPERIIRHALNLKKALRNSSKNKAFSGEDLVKYQEAWSQKYTFTAMINWYRAGMRYQFSTIAKQEMRSKLVEAPTMIIWGKKDAYLSWKMVEPSAKMCKSCAVHYIDDATHWVHREYPEDVNRRMDTFFTN
>NZ_AP019860.1|WP_151971637.1|8489384_8489906_-|YkgJ-family-cysteine-cluster-protein
MKDGFIRKTIKRIALLRYQADLAATRFLLKRKGKPTYQLRGACKMCARCCEAPSIRVNVVFFYFKSLRYLLLKWHSVINGFVFERENPQLRMIVFRCTHFDPKTRMCDSYDSRPGMCRDYPRNLIYSTNPEFFPECGYYATLPNAKKFSQSLDKLNLPPEKLEELKRNLHIKE
>NZ_AP019860.1|WP_151971638.1|8489977_8491519_-|Rne/Rng-family-ribonuclease
MTKRIMLINVNEPEENRIAVIDNDRLEELYIERASSLGHVGNIYKGKVVNIEPSIQAAFVDIGEGRNGFLHVSDVMPIYGHMNSSNNSRDRNNRHRNNHRRKREKKIQDLLSKNAEVLVQITKEGIGTKAPTLTTYLSLPGRYIVLMPSIKRSGVSRKIVDEKVRRRLKKTLTELEPPKGMGYIIRTAGSDKTKDELGRDLNYLLDLWKVITRRAKHSTSPATIYQESDLVTRTLRDIFTDDVEEIIVDSEDDYQKALDFMSLLSSDYEDRVQLYNSHTPLFHEYRIEAEIEKIYKKHVPLKSGGHLAIEQTEALVAIDVNSGKYTGEEDIEETALQINLEAAVEIPRQLRLRDLGGVIINDFIDMKDEKNKEIVERVFRDEVRKDRARNRVAKISPFGIIEMTRQRLGPSLKSYTHNVCPYCDGHGWIKNLESMSLLIMRKIKLGALSGNIHKIIATMNPEVALDLANRKRKALHELEEKIGISILINPSDAFSIEDSKVEYFNRTGLPIQL
>NZ_AP019860.1|WP_151971639.1|8491725_8493537_-|hypothetical-protein
MRFCYIFAIIICCLLTLPIQAQQSTPPQARSELISIDVRDKPFSDIIEGIREQTNKNIIYDDEIKDVYVTIKLVQLPWLMVLKTIAKRHNCIVEELDLQVIKISKPAVVRMEFSGADIRDVIDQIAGLANKNIIISEAVKGPVNLRLHDVAWRDALDAIVKNSGFVIVEENNILRVVRPEDIETQVETAIFRLRYIRPKSPFVAQMQSNFVFSPNQQQIQQGQTPQIGQGSGVQTSNFSLLNALQTVVTPNRGKITYDDGTNTLVITDTRPKLDKMAQIIKKLDKEPRQIFIDVKFVQTQNSDIFNFGLGFGDTGIEITHTFPDLLSRLPFTNGDSGFEDVIAFATDAQRDEGIPNDANIEAIQDNDGPINEVGQLDFKNTQFVFKLFKQDVKTKVIQAPKLITLDHHEATIFVGDTISFAKTEFIENDNGNLSVQLVEADDSPVTEGFQLLVVPHVIPDTNKVQLTVVLSNTLLSGQDDNAGIAGFNRFVAGDVEILLPQLTEQVVVTHMILESSQTAIVGGLLQITETENINKVPFLGDLPMLGYFFKRKDINKQKDDLFIFITPRIVESAQNTQQKLRVDINDYRKRDEKQFNTIWGGNK
>NZ_AP019860.1|WP_151971640.1|8493983_8495594_-|hypothetical-protein
MNKLTEKQMNLAIVGAGVLVAIIFFTMRHFDQEEIVRLANEKKGIDSQVQQLKNKERQIEAKKQELYLMRANTDAVKRLLPQDKKVTEFFELMEQFRLQNEIQAFNKVNKVDPHFEIREDDEEDAGPKPPQVGFRPPVAVPTASNPFVEDGYHVEFKGSFNNLGELISKIESHERFFSVKEIKIEYANGNLEVDLKDQVMKGKVQLVVTTFTFQNPDPTIDEKLAKILDGYEPSTLLKQKVRERREELLKRYVFQWTELELIDDPFYPFRRIEIIVPKPDGLVTGEALDDASAGEIPEKKIEEMYNAVNTLYNDTLKPLSLEGDWTKLEDALKENNMQEQLRRLNLLTFPSEFDADGQKRDKLNKIREDIKVWETYIAEISKEKALQKLIATLSEKVNDVANLYKKARKKGDAPELLNQVVKKHNDIMPEILEHKDKEPQYKVLSSARKKLEFYYKKAKIQLELIERVKKLELTGVIYQPDKKKPSVAFINKKPVRTRNSLPSGFVVKEINNGWVVLDYKGETVPLRMKSLAAKQN
>NZ_AP019860.1|WP_151971641.1|8495590_8496271_-|hypothetical-protein
MITINLLPPEEREAPPTSAARLLVIAASALIALVSVVFYAMTHYIDLPNMQTALQKSKKELAEWQSKKIPQRHTQAFQVATVLKKREDTIENIRLLKSEMARKLTEYAQIIKEHEYSWSGDLHIKRNDAPSNARRRLIPGQIVQQNTIKIPTYEWAYAARTAGDKLQTAINYYKAIQRHPSFWRDFERIATPEYELQEEDPELFKPHLGYKFDIRMTMKMNRKKKK
>NZ_AP019860.1|WP_151971642.1|8496274_8497324_-|type-IV-pilus-assembly-protein-PilM
MFRRKNTILGLDIGTSSIKAIEMSSSGGSGDFSITGYGQVAITDVENPLNDIKELLHTSGIKSKRVITGVSGREVIVRYISMQPVDKENLAEAVRFEADKYIPYDLEEVVLDSQRLDDDTTVNVSTSGEMKVLLVAAKRSLIESRVGLLRSSELHPSIIDVDSFALGNAFVLKSMLSPRPEVEGKIVSLVDIGCTKTNINIMIGNTSFFTREIYLAGNEFTEEIQKRLEVTTEEAEGLKREPGIFALEVQEAVAPVIEDLANEITLSFEYFEGQFEREVEEIFVSGGGSQLFSLEPDFERIFGKRINRWDPTENFEIREDQVDIDALRANSSQLAIAIGLASRIYQNKV
>NZ_AP019860.1|WP_151971643.1|8497962_8498439_+|phasin-family-protein
MEIANNITQTTQNIPQKLLQKSCEAQENLKQQLKKLGLATLGAFSLYQEQAGEKIKQFVLKGTEVEKNLNTWANGLWKKGYSETKQTINDVEKTLEISNLLSKMNIPTKSDVEALAQKVEALNSKIDEIITATKNETTETTEITTTEEIIATSASSQA
>NZ_AP019860.1|WP_151971644.1|8498613_8499144_+|dCTP-deaminase
MSILTRDEILKAVSAKEIAIAPFDEDHVGPASVDLHLSHSFRVFDKPKKVIRVQNDVDYRKATKGVRLKEGETFLLMPGETILGITVERITLSDGICGWLEGRSKFARVGLLIHISASFMQPGIDNHQVLEMSNFGPVPLEIVPGVRICQFIFQRTIGNAAYQGKFRNQCPEEFSL
>NZ_AP019860.1|WP_151971645.1|8499543_8500965_-|hypothetical-protein
MKVKKIKIMASYDWSMCYTVSEFFKFLDPVVHYKGEKYRLELGRVIAKPLLCGQNLNNEVDFVVDRTIHWNDYYKCWAQQAINSQMSIVNHSNTFQNHDKHSTYDLMARAMHPKDRFPKTVLLPQFYPYTEDLEKHEEWKDLQGYITKYTKFGHDENLRQTDWEKINNQMERAKHFREQGKVVRAQYYDKGNYLKDAMETYFDNQFPIFLKKAFGGGGSDVFKIDSMDELYAKYDETDGRTFHLQEAIENYDLFVRCIAAGPQVLPMRFQPDHPHHQHYSEEKLHMDKDMYVRLRNYVLFINSFHRWTYNSYEALVKNGQIHPIDFANACPDSHFTSLHVHFPWVVCACLKWFMYCAVTGKDMRIDLEQKKYLSVLNDPNKSAQEKYDFYSKLNEEYFETEDFEKFCNENFADMEEKMLQFYDQRIDDVIRYALYYSDFPKHEHDQFFHYYKQMMEENFRANPKEYLSTVLYN

Crispr_ID: NZ_AP019860_43

• CRISPR_ID: NZ_AP019860_43
• CRISPR_location: 8499143-8499242
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_43

Consensus_repeat	Method
AGAAATTCTTTCTCCGGATTGGTG	CRISPRCasFinder

spacers of NZ_AP019860_43

>43.1|8499167|52|NZ_AP019860|CRISPRCasFinder
AGATGAGAGATTCTTTCTCCGGATTGGTGCCCTCATCATCGCGGCTAAGATG

CRISPR arrays and Neighbor proteins around NZ_AP019860_43

CRISPR arrays

The CRISPR arrays of NZ_AP019860_43

>merge|NZ_AP019860|43|8499143-8499242|CRISPRCasFinder
AGAAATTCTTTCTCCGGATTGGTGAGATGAGAGATTCTTTCTCCGGATTGGTGCCCTCATCATCGCGGCTAAGATGAGAAATTCTTTCTCCGGATTGGTG

>NZ_AP019860|43|36|8499143-8499242|CRISPRCasFinder
AGAAATTCTTTCTCCGGATTGGTG	AGATGAGAGATTCTTTCTCCGGATTGGTGCCCTCATCATCGCGGCTAAGATG
AGAAATTCTTTCTCCGGATTGGTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151971639.1|8491725_8493537_-|hypothetical-protein	unknown	unknown	gnl|CDD|274173
NZ_AP019860.1|WP_151971652.1|8508979_8509345_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971651.1|8506587_8508798_-|primosomal-protein-N'	unknown	unknown	gnl|CDD|235514
NZ_AP019860.1|WP_151971649.1|8505309_8506401_-|DHH-family-phosphoesterase	unknown	unknown	gnl|CDD|223691
NZ_AP019860.1|WP_151971653.1|8509474_8509720_-|50S-ribosomal-protein-L27	unknown	unknown	gnl|CDD|235464
NZ_AP019860.1|WP_151971635.1|8486412_8486853_-|tripartite-tricarboxylate-transporter-TctB-family-protein	unknown	unknown	gnl|CDD|377815
NZ_AP019860.1|WP_151971636.1|8488513_8489380_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_AP019860.1|WP_151971640.1|8493983_8495594_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971642.1|8496274_8497324_-|type-IV-pilus-assembly-protein-PilM	unknown	unknown	gnl|CDD|378558
NZ_AP019860.1|WP_151971647.1|8504263_8504791_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971645.1|8499543_8500965_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971643.1|8497962_8498439_+|phasin-family-protein	unknown	unknown	gnl|CDD|377530
NZ_AP019860.1|WP_151971637.1|8489384_8489906_-|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl|CDD|223799
NZ_AP019860.1|WP_151971641.1|8495590_8496271_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_152022077.1|8502301_8503678_+|DEAD/DEAH-box-helicase-family-protein	unknown	unknown	gnl|CDD|223989
NZ_AP019860.1|WP_151971648.1|8504905_8505271_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971646.1|8500945_8502088_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NZ_AP019860.1|WP_151971638.1|8489977_8491519_-|Rne/Rng-family-ribonuclease	unknown	unknown	gnl|CDD|273254
NZ_AP019860.1|WP_151971650.1|8506413_8506578_-|Trm112-family-protein	unknown	unknown	gnl|CDD|225391
NZ_AP019860.1|WP_152022076.1|8486849_8487836_-|tripartite-tricarboxylate-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|225722

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151971639.1|8491725_8493537_-|hypothetical-protein	gnl|CDD|274173	TIGR02515, Putative_DNA_transport_protein_HofQ, type IV pilus secretin (or competence protein) PilQ. A number of proteins homologous to PilQ are involved in type IV pilus formation, competence for transformation, type III secretion, and type II secretion (also called the main terminal branch of the general secretion pathway). Members of this family include PilQ itself, which is a component of the type IV pilus structure, from a number of species. In Haemophilus influenzae, the member of this family is associated with competence for transformation with exogenous DNA rather than with formation of a type IV pilus; the surface structure required for competence may be considered an unusual, incomplete type IV pilus structure. [Cell envelope, Surface structures].	2.74987e-52
NZ_AP019860.1|WP_151971653.1|8509474_8509720_-|50S-ribosomal-protein-L27	gnl|CDD|235464	PRK05435, rpmA, 50S ribosomal protein L27; Validated.	1.34665e-39
NZ_AP019860.1|WP_151971635.1|8486412_8486853_-|tripartite-tricarboxylate-transporter-TctB-family-protein	gnl|CDD|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	1.37145e-08
NZ_AP019860.1|WP_151971636.1|8488513_8489380_+|alpha/beta-fold-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.12847e-40
NZ_AP019860.1|WP_151971649.1|8505309_8506401_-|DHH-family-phosphoesterase	gnl|CDD|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	1.23139e-30
NZ_AP019860.1|WP_151971651.1|8506587_8508798_-|primosomal-protein-N'	gnl|CDD|235514	PRK05580, PRK05580, primosome assembly protein PriA; Validated.	0
NZ_AP019860.1|WP_151971643.1|8497962_8498439_+|phasin-family-protein	gnl|CDD|377530	pfam05597, Phasin, Poly(hydroxyalcanoate) granule associated protein (phasin). Polyhydroxyalkanoates (PHAs) are storage polyesters synthesized by various bacteria as intracellular carbon and energy reserve material. PHAs are accumulated as water-insoluble inclusions within the cells. This family consists of the phasins PhaF and PhaI which act as a transcriptional regulator of PHA biosynthesis genes. PhaF has been proposed to repress expression of the phaC1 gene and the phaIF operon.	5.73858e-06
NZ_AP019860.1|WP_151971637.1|8489384_8489906_-|YkgJ-family-cysteine-cluster-protein	gnl|CDD|223799	COG0727, COG0727, Predicted Fe-S-cluster oxidoreductase [General function prediction only].	1.19996e-05
NZ_AP019860.1|WP_152022076.1|8486849_8487836_-|tripartite-tricarboxylate-transporter-substrate-binding-protein	gnl|CDD|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	1.38394e-82
NZ_AP019860.1|WP_152022077.1|8502301_8503678_+|DEAD/DEAH-box-helicase-family-protein	gnl|CDD|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	1.54195e-93
NZ_AP019860.1|WP_151971642.1|8496274_8497324_-|type-IV-pilus-assembly-protein-PilM	gnl|CDD|378558	pfam11104, PilM_2, Type IV pilus assembly protein PilM;. The type IV pilus assembly protein PilM is required for competency and pilus biogenesis. It binds to PilN and ATP.	3.93635e-59
NZ_AP019860.1|WP_151971646.1|8500945_8502088_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	6.1928e-16
NZ_AP019860.1|WP_151971638.1|8489977_8491519_-|Rne/Rng-family-ribonuclease	gnl|CDD|273254	TIGR00757, Ribonuclease_E/G-like_protein, ribonuclease, Rne/Rng family. This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA].	3.24572e-167
NZ_AP019860.1|WP_151971650.1|8506413_8506578_-|Trm112-family-protein	gnl|CDD|225391	COG2835, COG2835, Uncharacterized conserved protein [Function unknown].	7.75407e-07

Protein sequences

>NZ_AP019860.1|WP_151971643.1|8497962_8498439_+|phasin-family-protein
MEIANNITQTTQNIPQKLLQKSCEAQENLKQQLKKLGLATLGAFSLYQEQAGEKIKQFVLKGTEVEKNLNTWANGLWKKGYSETKQTINDVEKTLEISNLLSKMNIPTKSDVEALAQKVEALNSKIDEIITATKNETTETTEITTTEEIIATSASSQA
>NZ_AP019860.1|WP_151971642.1|8496274_8497324_-|type-IV-pilus-assembly-protein-PilM
MFRRKNTILGLDIGTSSIKAIEMSSSGGSGDFSITGYGQVAITDVENPLNDIKELLHTSGIKSKRVITGVSGREVIVRYISMQPVDKENLAEAVRFEADKYIPYDLEEVVLDSQRLDDDTTVNVSTSGEMKVLLVAAKRSLIESRVGLLRSSELHPSIIDVDSFALGNAFVLKSMLSPRPEVEGKIVSLVDIGCTKTNINIMIGNTSFFTREIYLAGNEFTEEIQKRLEVTTEEAEGLKREPGIFALEVQEAVAPVIEDLANEITLSFEYFEGQFEREVEEIFVSGGGSQLFSLEPDFERIFGKRINRWDPTENFEIREDQVDIDALRANSSQLAIAIGLASRIYQNKV
>NZ_AP019860.1|WP_151971641.1|8495590_8496271_-|hypothetical-protein
MITINLLPPEEREAPPTSAARLLVIAASALIALVSVVFYAMTHYIDLPNMQTALQKSKKELAEWQSKKIPQRHTQAFQVATVLKKREDTIENIRLLKSEMARKLTEYAQIIKEHEYSWSGDLHIKRNDAPSNARRRLIPGQIVQQNTIKIPTYEWAYAARTAGDKLQTAINYYKAIQRHPSFWRDFERIATPEYELQEEDPELFKPHLGYKFDIRMTMKMNRKKKK
>NZ_AP019860.1|WP_151971640.1|8493983_8495594_-|hypothetical-protein
MNKLTEKQMNLAIVGAGVLVAIIFFTMRHFDQEEIVRLANEKKGIDSQVQQLKNKERQIEAKKQELYLMRANTDAVKRLLPQDKKVTEFFELMEQFRLQNEIQAFNKVNKVDPHFEIREDDEEDAGPKPPQVGFRPPVAVPTASNPFVEDGYHVEFKGSFNNLGELISKIESHERFFSVKEIKIEYANGNLEVDLKDQVMKGKVQLVVTTFTFQNPDPTIDEKLAKILDGYEPSTLLKQKVRERREELLKRYVFQWTELELIDDPFYPFRRIEIIVPKPDGLVTGEALDDASAGEIPEKKIEEMYNAVNTLYNDTLKPLSLEGDWTKLEDALKENNMQEQLRRLNLLTFPSEFDADGQKRDKLNKIREDIKVWETYIAEISKEKALQKLIATLSEKVNDVANLYKKARKKGDAPELLNQVVKKHNDIMPEILEHKDKEPQYKVLSSARKKLEFYYKKAKIQLELIERVKKLELTGVIYQPDKKKPSVAFINKKPVRTRNSLPSGFVVKEINNGWVVLDYKGETVPLRMKSLAAKQN
>NZ_AP019860.1|WP_151971639.1|8491725_8493537_-|hypothetical-protein
MRFCYIFAIIICCLLTLPIQAQQSTPPQARSELISIDVRDKPFSDIIEGIREQTNKNIIYDDEIKDVYVTIKLVQLPWLMVLKTIAKRHNCIVEELDLQVIKISKPAVVRMEFSGADIRDVIDQIAGLANKNIIISEAVKGPVNLRLHDVAWRDALDAIVKNSGFVIVEENNILRVVRPEDIETQVETAIFRLRYIRPKSPFVAQMQSNFVFSPNQQQIQQGQTPQIGQGSGVQTSNFSLLNALQTVVTPNRGKITYDDGTNTLVITDTRPKLDKMAQIIKKLDKEPRQIFIDVKFVQTQNSDIFNFGLGFGDTGIEITHTFPDLLSRLPFTNGDSGFEDVIAFATDAQRDEGIPNDANIEAIQDNDGPINEVGQLDFKNTQFVFKLFKQDVKTKVIQAPKLITLDHHEATIFVGDTISFAKTEFIENDNGNLSVQLVEADDSPVTEGFQLLVVPHVIPDTNKVQLTVVLSNTLLSGQDDNAGIAGFNRFVAGDVEILLPQLTEQVVVTHMILESSQTAIVGGLLQITETENINKVPFLGDLPMLGYFFKRKDINKQKDDLFIFITPRIVESAQNTQQKLRVDINDYRKRDEKQFNTIWGGNK
>NZ_AP019860.1|WP_151971638.1|8489977_8491519_-|Rne/Rng-family-ribonuclease
MTKRIMLINVNEPEENRIAVIDNDRLEELYIERASSLGHVGNIYKGKVVNIEPSIQAAFVDIGEGRNGFLHVSDVMPIYGHMNSSNNSRDRNNRHRNNHRRKREKKIQDLLSKNAEVLVQITKEGIGTKAPTLTTYLSLPGRYIVLMPSIKRSGVSRKIVDEKVRRRLKKTLTELEPPKGMGYIIRTAGSDKTKDELGRDLNYLLDLWKVITRRAKHSTSPATIYQESDLVTRTLRDIFTDDVEEIIVDSEDDYQKALDFMSLLSSDYEDRVQLYNSHTPLFHEYRIEAEIEKIYKKHVPLKSGGHLAIEQTEALVAIDVNSGKYTGEEDIEETALQINLEAAVEIPRQLRLRDLGGVIINDFIDMKDEKNKEIVERVFRDEVRKDRARNRVAKISPFGIIEMTRQRLGPSLKSYTHNVCPYCDGHGWIKNLESMSLLIMRKIKLGALSGNIHKIIATMNPEVALDLANRKRKALHELEEKIGISILINPSDAFSIEDSKVEYFNRTGLPIQL
>NZ_AP019860.1|WP_151971637.1|8489384_8489906_-|YkgJ-family-cysteine-cluster-protein
MKDGFIRKTIKRIALLRYQADLAATRFLLKRKGKPTYQLRGACKMCARCCEAPSIRVNVVFFYFKSLRYLLLKWHSVINGFVFERENPQLRMIVFRCTHFDPKTRMCDSYDSRPGMCRDYPRNLIYSTNPEFFPECGYYATLPNAKKFSQSLDKLNLPPEKLEELKRNLHIKE
>NZ_AP019860.1|WP_151971636.1|8488513_8489380_+|alpha/beta-fold-hydrolase
MQLQHKQIQANGVKLHVVEGGNENGDAIIFLHGFPDFWYGWQKQIAYFVEKGYRVIAPDQRGYNLSDKPRGVRNYHLDTLTSDIVALMDNLHIDQAYVVGHDWGGGIAWWLATNYPQRVKKLVICNMPHLVVLRNYLLSSVRQMCRSWYMLAFQVPFLPERIIRHALNLKKALRNSSKNKAFSGEDLVKYQEAWSQKYTFTAMINWYRAGMRYQFSTIAKQEMRSKLVEAPTMIIWGKKDAYLSWKMVEPSAKMCKSCAVHYIDDATHWVHREYPEDVNRRMDTFFTN
>NZ_AP019860.1|WP_152022076.1|8486849_8487836_-|tripartite-tricarboxylate-transporter-substrate-binding-protein
MPFLIILTAACFFLSIRKSPQNLHSDSIQQIHFLVPGGVGGGWDTTARTVGEVLRKAKLVPQISYENLSGGGGGKAIAHVIETAKHQQQTLMVNSTPIVIRSLQKVFPQSFRDLTPIASIIGDYSCLVVTKDSKYNNWSQIVAEYRQKPSKISIAGGSVKGGMDHLVAAMICEACEIELSDLVYIPYDAGGKALAGLISGETQLLSTGLGEAMELAKAGQLKIIAVTAPNRVKAISDIPTFRELGYDVVFANWRGFFAPPGIHEKQRKLYDKLFRKMYDEVLWKEARKKNGWSEIYYANDEFTQFLQRQEQQLQKLMTKLGFIKETQK
>NZ_AP019860.1|WP_151971635.1|8486412_8486853_-|tripartite-tricarboxylate-transporter-TctB-family-protein
MNEQRVGGVIFFVFCALYLFFATDITVTSESTFSARTFPYILGVMGCIVSLLLIVLPSIQKTIALTQLKWSAVFAMCLAMLVYAFLLSRIGFIIATILFLNTCFIIMRERKWRHMFYTSFSLTCIFWLLLTQVLNIYLAPGSWWMG
>NZ_AP019860.1|WP_151971645.1|8499543_8500965_-|hypothetical-protein
MKVKKIKIMASYDWSMCYTVSEFFKFLDPVVHYKGEKYRLELGRVIAKPLLCGQNLNNEVDFVVDRTIHWNDYYKCWAQQAINSQMSIVNHSNTFQNHDKHSTYDLMARAMHPKDRFPKTVLLPQFYPYTEDLEKHEEWKDLQGYITKYTKFGHDENLRQTDWEKINNQMERAKHFREQGKVVRAQYYDKGNYLKDAMETYFDNQFPIFLKKAFGGGGSDVFKIDSMDELYAKYDETDGRTFHLQEAIENYDLFVRCIAAGPQVLPMRFQPDHPHHQHYSEEKLHMDKDMYVRLRNYVLFINSFHRWTYNSYEALVKNGQIHPIDFANACPDSHFTSLHVHFPWVVCACLKWFMYCAVTGKDMRIDLEQKKYLSVLNDPNKSAQEKYDFYSKLNEEYFETEDFEKFCNENFADMEEKMLQFYDQRIDDVIRYALYYSDFPKHEHDQFFHYYKQMMEENFRANPKEYLSTVLYN
>NZ_AP019860.1|WP_151971646.1|8500945_8502088_-|tetratricopeptide-repeat-protein
MIRLLICSVVFVCGCATTTENLNNEGIALANQQKYQQALQKFLEAYRQKPDRFENCLNVAQMYVMLKDPQQAIVYIDKALELNAQVLDIHILKMQVLLLQGKKAQALEILDSVAEKNHNNPRLYALLLSMGDNALSQKKWEESRQWYQKAIDLSPEESKAYIALSRALIFKGSHAQNSYENFATSSEVRDSDFNKAKAALRKAVYLDKDSVDAHLMLGMIAMQTQNYQDAQLEFAEVLRIDSNHLIALTAASFNQSQMGNISKSMEYLQSAQQLYPDRAEPLWLKANLLIQQQSFSEAVATYITIWTKFPNLRDSIVQNFRMNFSHYFPWLVKLITDSNQQIADFSFDMLKEVSRQNFARDVAKWQMWYKEKGQHESQKN
>NZ_AP019860.1|WP_152022077.1|8502301_8503678_+|DEAD/DEAH-box-helicase-family-protein
MITISFYQGTLSIVVNSDNSFVVQSIPGCKWDHRTQCFRLPAFKYHELITVLYNKEIPYKDEARLYEILQMDHQLDREPFHHQKQAIASWNKFRKRGYVVLPTGTGKSFVAILAMLESKRSTAIVVPTIDLMHQWYDNVKNFFPNIPIGLIGGGNYQPASITITTYDSAYIHFDKIGNLFGLVIFDECHHLPGRTYRLGAEFILAPYRLGLSATPERLDGGHNDLNYLIGPCVFRKEINEMAGPYLADYNVVQVTARLSAEERKEYQKNRSLYVTFLRRNYLQMGRNGWQKFIQVSHRTEEGRRAFIAYRKQKQIAQATPSKLKTLEYLIRKHHNERLLIFTHDNATAYKISLRFLVPVITHQTKIKERKDILKKYSEGVYSIIVTSKVLNEGVDIPSASIGIILSGSASVREHVQRLGRILRKHGDKKATLYEVVTEGTSEESVSQRRREHNAYKRE
>NZ_AP019860.1|WP_151971647.1|8504263_8504791_-|hypothetical-protein
MSLEEKWQKAAKETRIIRSRLQRLSNTEATTLSYIFLAPSLVNTGDTVVRTGKIIVDKPAIILPKNLPQFFGFDFQDELGVNDDSVRSFLIIRGIQYPSLKYQNEISTIDVFEGNVDSAIAHFGNDLERKEDIETALLVGNTEAWQLSLLIYVSVLIQRSLPKDLDNLFDQFKDF
>NZ_AP019860.1|WP_151971648.1|8504905_8505271_-|hypothetical-protein
MTTQEKSNISLLFILQVALVSIMLLFIVGFAMDATYNPLYFFITLSAPAIALQQKLSILPTSFLLIIAVPYVIVCPVVSGIFCTLKSCNIKEVLVTCFASIFTAFIIHAAGFYISILPYAG
>NZ_AP019860.1|WP_151971649.1|8505309_8506401_-|DHH-family-phosphoesterase
MTTKNGKTNKIATKSTTKTQQLQKIFTEKVKKVAIFIGNPDPDSIGAGLGMNLFIQRTCGAVCDLIYEGQVSHPQNKTLLNVLNIHFLNKDEVFGSDHPPLDEVYDKFVCVDHVPRERWCKELNMTAVIDHHKVNYNDSDFVDIRQVGSCCSIVLSYLLEAEIDFSQDDDGLLSKAVTAMLFGVKTDTLDLMSESVTDLDFDAYQHLVKYVSRSELEPIINYQLPAYYFDIRRVLEEEGNSITKGSFFVAGIGIITAARRDCLPMLADERVRMEGISTAIIFAVVDNYVEASIRSSNPAVDVNSFCKKVFGRDYAGGKLGAGAAKIPMGILAIDSLPADLKKEAWETYRKIIMTKVFRICDSE
>NZ_AP019860.1|WP_151971650.1|8506413_8506578_-|Trm112-family-protein
MLTKKILHLLSCTVCDEKLIEHSKGLLCESCNKIYPIEDEIIILLPEKAIDNVK
>NZ_AP019860.1|WP_151971651.1|8506587_8508798_-|primosomal-protein-N'
MYAQVALPLPLKQLFSYSIPEDCTLETGMRVKVPFGRRTQIGVCIETVAQIENTKFRIKSIHEVIDTKPVIDCAMLELAKWMSQYYRCSLGEALETMVPSFLQQKSYSKTIAYLQIAAHEEIEQQIEQLQTKFPLQARVLKLVREFDGELTAKSICNRLGISRSAIKTLLKKELLCERFEEQNINPFDEIEVEKVEKPQLSREQQSIVNNLLPVMREQRFFPALVHGVTGSGKTEIYMRCIEEVVDNKRAAIVLVPEIALTPQTVTRFKQRFANVAVLHSELTNAQRNFQWQNILQNKADVIIGPRSALFAPVSNLGLIVVDEEHEPSFKQQNTPRYNARDSAVKRAQISDIPIILGSATPALESYYNTDTDKYNLFALHQRVGDKKLPHVSVIDMKEECRDHKKFVYFSRILLNDLRAALDKGQQAILFLNRRGFATSLTCPQCGYNAKCDNCNIALTYHKKHHTAICHYCNYDYIPPKSCPVCSCPAILYAGAGTQKIEMMLKKIFPENNIVRMDSDTMVGKGKYEDVLSRFGKGEIDILLGTQMIAKGLDFPNVTLVGIISADTALQVPDFRAAERTFQLIVQVAGRSGRGEVAGKVIVQTYHPDHYAIQTAIHQDYHSFLKYEMGQRKDIGYPPFAKLLRVLIQGEKEQLVIDESLRISRCLRQDKYAKNIQILGPAPAPIDRIKNRYRHHLIIKCQSVQLSMHFSVFLDRIMEDSHKSLRVSLDVDPISLV
>NZ_AP019860.1|WP_151971652.1|8508979_8509345_-|hypothetical-protein
MDTKKLLVLVLSWLLPGSGYWFVQQRLKSGILFLLIVPTYFLGICMLDFSTYFLHKHRFYYVLNFVIGLPGILFVNFATSTPQLVSSPDVIQLGFLCIAVSSLLNILLFSKIYFTLSKVSR
>NZ_AP019860.1|WP_151971653.1|8509474_8509720_-|50S-ribosomal-protein-L27
MAHKKGQGASRNGRDSNAQFRGIKKYGGENVKPGTIIVRQCGTRFKPGVNVGLGNDYTIYSLIGGKVKFERNRVISVLPAE

Crispr_ID: NZ_AP019860_44

• CRISPR_ID: NZ_AP019860_44
• CRISPR_location: 8656210-8656419
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of NZ_AP019860_44

Consensus_repeat	Method
GGTGTCAGACTCACCATCGGTGTCAGACTCACTTTT	CRT

spacers of NZ_AP019860_44

>44.1|8656246|24|NZ_AP019860|CRT
TGAGAAAGAAAATGCACAACCACT
>44.2|8656306|18|NZ_AP019860|CRT
AGTGTCAGACTCACCACT
>44.3|8656360|24|NZ_AP019860|CRT
TGAGAAAGAAAGTGCACAACCACC

CRISPR arrays and Neighbor proteins around NZ_AP019860_44

CRISPR arrays

The CRISPR arrays of NZ_AP019860_44

>merge|NZ_AP019860|44|8656210-8656419|CRT
GGTGTCAGACTCACCATCGGTGTCAGACTCACTTTTTGAGAAAGAAAATGCACAACCACTGGTGTCAGACTCACCACCGGTGTCAGACTCACCACCAGTGTCAGACTCACCACTGGTGTCAGACCCACCATCGGTGTCAGACTCACTTTTTGAGAAAGAAAGTGCACAACCACCGGTGTCAGACTCACCATCGGTATCAGACTCACTTTT

>NZ_AP019860|44|5|8656210-8656419|CRT
GGTGTCAGACTCACCATCGGTGTCAGACTCACTTTT	TGAGAAAGAAAATGCACAACCACT
GGTGTCAGACTCACCACCGGTGTCAGACTCACCACC	AGTGTCAGACTCACCACT
GGTGTCAGACCCACCATCGGTGTCAGACTCACTTTT	TGAGAAAGAAAGTGCACAACCACC
GGTGTCAGACTCACCATCGGTATCAGACTCACTTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151971753.1|8655075_8655741_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187586
NZ_AP019860.1|WP_151971750.1|8652465_8652798_+|30S-ribosomal-protein-S16	unknown	unknown	gnl|CDD|223306
NZ_AP019860.1|WP_151971759.1|8670511_8674603_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|223715
NZ_AP019860.1|WP_151971748.1|8649619_8650801_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|215470
NZ_AP019860.1|WP_151971749.1|8650914_8652363_+|signal-recognition-particle-protein	unknown	unknown	gnl|CDD|236780
NZ_AP019860.1|WP_151971751.1|8652864_8653626_+|hypothetical-protein	unknown	unknown	gnl|CDD|223255
NZ_AP019860.1|WP_151971758.1|8668924_8670271_+|DUF2817-domain-containing-protein	unknown	unknown	gnl|CDD|349483
NZ_AP019860.1|WP_151971764.1|8677586_8679584_+|oligopeptidase-A	unknown	unknown	gnl|CDD|341051
NZ_AP019860.1|WP_151971757.1|8668180_8668699_-|YiiD-C-terminal-domain-containing-protein	unknown	unknown	gnl|CDD|373120
NZ_AP019860.1|WP_173013664.1|8676886_8677396_-|protease-complex-subunit-PrcB-family-protein	unknown	unknown	gnl|CDD|379569
NZ_AP019860.1|WP_151971760.1|8674638_8674911_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971744.1|8644748_8645780_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	unknown	unknown	gnl|CDD|236515
NZ_AP019860.1|WP_151971762.1|8675360_8676800_+|peptidase-S10	unknown	unknown	gnl|CDD|225490
NZ_AP019860.1|WP_151971746.1|8648235_8649084_+|TraB/GumN-family-protein	unknown	unknown	gnl|CDD|350614
NZ_AP019860.1|WP_151971747.1|8649092_8649608_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971745.1|8645769_8647938_-|methylmalonyl-CoA-mutase	unknown	unknown	gnl|CDD|236508
NZ_AP019860.1|WP_151971755.1|8663192_8666798_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971756.1|8666872_8668171_-|M48-family-metalloprotease	unknown	unknown	gnl|CDD|223575
NZ_AP019860.1|WP_151971761.1|8674915_8675371_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971752.1|8653668_8654901_-|imidazolonepropionase	unknown	unknown	gnl|CDD|236478

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151971753.1|8655075_8655741_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187586	cd05325, carb_red_sniffer_like_SDR_c, carbonyl reductase sniffer-like, classical (c) SDRs. Sniffer is an NADPH-dependent carbonyl reductase of the classical SDR family. Studies in Drosophila melanogaster implicate Sniffer in the prevention of neurodegeneration due to aging and oxidative-stress. This subgroup also includes Rhodococcus sp. AD45 IsoH, which is an NAD-dependent 1-hydroxy-2-glutathionyl-2-methyl-3-butene dehydrogenase involved in isoprene metabolism, Aspergillus nidulans StcE encoded by a gene which is part of a proposed sterigmatocystin biosynthesis gene cluster, Bacillus circulans SANK 72073 BtrF encoded by a gene found in the butirosin biosynthesis gene cluster, and Aspergillus parasiticus nor-1 involved in the biosynthesis of aflatoxins. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.29216e-80
NZ_AP019860.1|WP_151971750.1|8652465_8652798_+|30S-ribosomal-protein-S16	gnl|CDD|223306	COG0228, RpsP, Ribosomal protein S16 [Translation, ribosomal structure and biogenesis].	9.51802e-28
NZ_AP019860.1|WP_151971759.1|8670511_8674603_+|HAMP-domain-containing-protein	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.45936e-46
NZ_AP019860.1|WP_151971748.1|8649619_8650801_+|alpha/beta-fold-hydrolase	gnl|CDD|215470	PLN02872, PLN02872, triacylglycerol lipase.	7.25093e-17
NZ_AP019860.1|WP_151971749.1|8650914_8652363_+|signal-recognition-particle-protein	gnl|CDD|236780	PRK10867, PRK10867, signal recognition particle protein; Provisional.	0
NZ_AP019860.1|WP_151971751.1|8652864_8653626_+|hypothetical-protein	gnl|CDD|223255	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair].	0.000982147
NZ_AP019860.1|WP_151971758.1|8668924_8670271_+|DUF2817-domain-containing-protein	gnl|CDD|349483	cd18173, M14_CP_bacteria, bacterial peptidase M14 carboxypeptidase, uncharacterized. This family contains only bacterial carboxypeptidase (CP) members of the M14 family of metallocarboxypeptidases (MCPs), mostly of which have yet to be characterized. The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes eight members, of which five (CPN, CPE, CPM, CPD, CPZ) are considered enzymatically active, while the other three are non-active (CPX1, PCX2, ACLP/AEBP1) and lack the critical active site and substrate-binding residues considered necessary for CP activity. These non-active members may function as binding proteins or display catalytic activity towards other substrates. Unlike the A/B CP subfamily, enzymes belonging to the N/E subfamily are not produced as inactive precursors that require proteolysis to produce the active form; rather, they rely on their substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages that would otherwise damage the cell. In addition, all members of the N/E subfamily contain an extra C-terminal domain that is not present in the A/B subfamily. This domain has structural homology to transthyretin and other proteins and has been proposed to function as a folding domain. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation.	1.84813e-142
NZ_AP019860.1|WP_151971764.1|8677586_8679584_+|oligopeptidase-A	gnl|CDD|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
NZ_AP019860.1|WP_151971757.1|8668180_8668699_-|YiiD-C-terminal-domain-containing-protein	gnl|CDD|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	1.26115e-17
NZ_AP019860.1|WP_173013664.1|8676886_8677396_-|protease-complex-subunit-PrcB-family-protein	gnl|CDD|379569	pfam14343, PrcB_C, PrcB C-terminal. This domain is found at the C-terminus of Treponema denticola PrcB. PrcB interacts with the PrtP protease (dentilisin) and is required for the stability of the protease complex.	1.66649e-09
NZ_AP019860.1|WP_151971744.1|8644748_8645780_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB	gnl|CDD|236515	PRK09435, PRK09435, methylmalonyl Co-A mutase-associated GTPase MeaB.	4.36476e-178
NZ_AP019860.1|WP_151971762.1|8675360_8676800_+|peptidase-S10	gnl|CDD|225490	COG2939, COG2939, Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism].	2.64818e-75
NZ_AP019860.1|WP_151971746.1|8648235_8649084_+|TraB/GumN-family-protein	gnl|CDD|350614	cd14789, Tiki, Tiki homology domain antagonizes Wnt function via cleavage of amino-terminal residues. Tiki is a membrane-associated metalloprotease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. Wnt is essential in animal development and homeostasis. In xenopus, tiki is critical in head development. In human cells, TIKI inhibits Wnt-signaling, which is important in embryogenesis, homeostasis, and regeneration. Deregulation of WNT contributes to birth defects, cancer and various diseases. TIKI homology domains are part of the TraB family and are related to the Erythromycin esterase, GumN plant pathogens, RtxA toxins, and Campylobacter Jejuni heme-binding, Chan-like proteins. TraB/PrgY are identified in gut bacterium Enterococcus faecalis, but its function has not been well characterized. Plasmid-borne, TraB has been implicated in the regulation of pheromone sensitivity and specificity. Based on homology to TIKI activity, it has been proposed that TraB acts as a metalloprotease in the inactivation of mating pheromone. The TIKI/TraB family has 2 conserved GxxH motifs and conserved glutamate and arginine residues that may be catalytic.	4.46772e-68
NZ_AP019860.1|WP_151971745.1|8645769_8647938_-|methylmalonyl-CoA-mutase	gnl|CDD|236508	PRK09426, PRK09426, methylmalonyl-CoA mutase; Reviewed.	0
NZ_AP019860.1|WP_151971755.1|8663192_8666798_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	8.80366e-103
NZ_AP019860.1|WP_151971756.1|8666872_8668171_-|M48-family-metalloprotease	gnl|CDD|223575	COG0501, HtpX, Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones].	9.22076e-13
NZ_AP019860.1|WP_151971752.1|8653668_8654901_-|imidazolonepropionase	gnl|CDD|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	4.63846e-122

Protein sequences

>NZ_AP019860.1|WP_151971753.1|8655075_8655741_+|SDR-family-NAD(P)-dependent-oxidoreductase
MNILITGANRGLGLEFVQQYAENSQNRIFACSRNPQTLEKENVSTHKLDVTATEDIDNLKQQMGETSIDILIHNAGVYGSKSGFGSIDVDSWIHTLKVNTIAPIKLSEALIDNVAASDKKTIVIVTSKMGSISDNTSGGSYVYRSSKSAVNMAGVSMSRDLKEKGITVLLLHPGWVETDMGGPNALLKPKESIEGMRKVIREATINDSGTFFAYDGQKINW
>NZ_AP019860.1|WP_151971752.1|8653668_8654901_-|imidazolonepropionase
MVDLLIRNIGQLLSVPLKPKGNEPCDKIGMIKNGALAIKNGKIEWMGADCDVAKNISGSPREIDAKNHVVCPAFIDAHTHISGYPYGRADDFEVRIFGEESYAGIARKGGGIRTTIQCTQQASDAELQRVSGTILDEFMRHGVGTLEAKSGYGLEKEHEMRQIKLINELASSHAMTIIPTYLAHVLHSSISREEYVAQIVKDFIPHFAAHVKCVDVFCDAIAFSVTETQQIITAALDKHKFVSIHADQTSPFAAAEALAPMGVSSLSHLENISDAGIRAMKENDTIAIVFPTCSVHLNAPYSPYEKFVEAGIRVALSTDWNPGSSPCSNILLVGYFAAKYLRMPLHEVLRSITVHPACALHLESHLGSLEVGKEGDFCIFELQDWRDLFTQCGNTPRITLYKKGEVAFCS
>NZ_AP019860.1|WP_151971751.1|8652864_8653626_+|hypothetical-protein
MTTKKTQKIPKIITLLQKKYDCVTVKSKLTLTELIIYATLNEGETKKNTDKALNKLKEEFVDWNEVRVTHPREIEEALKDTLKGNTYQKAVTITEVLGEIFYVFNTLQLAFLLEQEFIDVHKQLLQIDSNYKLLATLLLHIATNSEYVTVQQTCVRVGKRIGLWNETTPSSLNKNINKNTEKYLTQLNVYLSLYGEDVCVSTGYDCNSCILLKECDFGQKRVEKKTKSPATTKKRKTEVAKKVSRSRQKSSKK
>NZ_AP019860.1|WP_151971750.1|8652465_8652798_+|30S-ribosomal-protein-S16
MAVRIRLTRIGRKDAPFYRIGAYDSRAPRNGKCLEFLGWYNPCNGDEDNQLRVKLERVQHWLSVGALPTHKTGILLKKAGVVLHKPKAAKAKKEKAAKPKGKKAKKQKKS
>NZ_AP019860.1|WP_151971749.1|8650914_8652363_+|signal-recognition-particle-protein
MFKTLSNKFYDIKNNFFSSGKINEKNIQDGIKAIEEALINADVNFRVVKGLVKRVKEKALGEELIKSVKPGDQFVQIVHYELVELMKSDDEERLPITKDLTVIMMVGLQGSGKTTTCGKLARYLIKKGHRPLLVAADTQRPAAIEQLKVLGKTLGEQISEERGEDFEVPVYSAPQDPPPKICKDAIPIAKENNNDIVILDTAGRLHIDDALMDELLSIRKKTKPDHVFFVMDSMTGQNAFDSAKIFNEQINIDGVVLTKLDSDAKGGAALSIKEVTGKPVKFVGVGEKLDALEEFHADRMANRILGMGDIVTLVDKAEQLMDEEKAEEMYQKMVDASFTMHDLLDQFQMIKKMGNLRDLMGMLPGGLGVQMQNVDIDESIFSRIEAIIHSMTPQERDMPDIINGSRKLRISKGSGTKVQEVNQLLNQFREMRKMMQNMSKSGMFGNMMSGMGGGLGGLGGMMPGMGGAKQRSRRKKKKRKKK
>NZ_AP019860.1|WP_151971748.1|8649619_8650801_+|alpha/beta-fold-hydrolase
MQQIEYTYTQDNVRLALARYKNPGGLPVILAHGLAQNSFFWDFPVKNHSFARYLFDKGYDVWLPCLRGHGRGALHSDNKSDWSWNIDDLAIYDVPAIIQKVLQMTSQKPFWVGHSMGGTLAYMYLQGALYTRRVVAKECIKIDGHVEYKNVHSAHVVACKEKADERNAQLNGLITVGSPVAMTWSHDPFLAKVINHPLWQELHVFSFLSNRKFLRSSLNKLPYLPVFSTLDVVEKMCGKWFQKMIHFPIAQIGTTKIFSLFWYPPNMNRHLVQTLMRESLNDICSQVLEQFADWIEHRTFRSFPNGNEKPHIYSEHFSAITLPLLIIAGEQDKIAKPSVLYREGFLKMGSAQKKYQCFDKFGHNDLCMGLRAPSKVFPYIEKWIAATTKHHFQ
>NZ_AP019860.1|WP_151971747.1|8649092_8649608_+|hypothetical-protein
MFIRISCFLILCVSICAQNSANNNFFVERQISKAKQIAEETKDVVVVVETELKALIIFCNGNFKHVLVHARKRQVGMNFYKMDFLLLDKIEGKDVVFKNPRRFRSFLASRNDITIRKNTFKSFTNKVTSSSEFFKAFVLNNRRRSTSRQDFIDVQIFDFREKKQRKKSKRK
>NZ_AP019860.1|WP_151971746.1|8648235_8649084_+|TraB/GumN-family-protein
MKKIVLLAIFIVAIVCQEASKATPIFWKIEAEKPVYLLGTIHLGVDAAKEFPAEVWENLQKCKTLVLEIDMSNVNQFAMMTKMQLPPGKTLDQLLGADYWSKFQEFVKPQPAALFKGFKPWVVQSIAAQKFMPLTPAVEMTLMEKANKSGIKIEALETMDDQLEAIDSVPEEEHVKSIKRMLDDTEGARKETLDLLNAYRSGDLGKIKKMALESEEAKEAPGMIEHVMVNRNKKWIPAIEKYIAKGNVFIAVGAAHFVGDNGVIKLLEAKGYKITRIEYTQE
>NZ_AP019860.1|WP_151971745.1|8645769_8647938_-|methylmalonyl-CoA-mutase
MKPDFTKVEYKVENINKYLEKSNSVDVGQSWQTPEKIEVKKLFSQDDIAHVEHLDFAAGLPPFLRGPYASMYTVRPWTIRQYAGFSTAEESNAFYRRNLKAGQKGLSVAFDLPTHRGYDSDHQRVEGDVGKAGVAVDSILDMEILFSQIPLDKISVSMTMNGAVLPILAFYIVAAEEQGVSQEKLRGTIQNDILKEFMVRNTYIYPPDPSMRIIGDIFSYMAQNMPKFNSISVSGYHMHEAGATADIEVAYTLADALEYLRLGLNAGIDIDLFAPRISFFWAIGMNHFTEIAKMRAARMLWAKLVKQFDPKNPKSMALRVHCQTSGWSLTEQDPFNNVARTCIEAMAAVCGHTQSLHTNALDEALALPTDFSARIARNTQLVIQEETNVTKNIDPWGGSYYVEKLTHDIAHRAWELIEEVEKMGGMSKAIAAGLPKKRIEEAAARKQARIDSRQDIIVGVNKYQVDEKSDLQILEVDNSTVRQKQLERLKELKQQRNSDEVQKTLDAITESASSGKGNLLALAVEAARKRATLGEISAACEKVFGRYEAHSQTISGVYAREIANDEDFIKAQQLTDEFAKLEGRRPRIMVAKVGQDGHDRGSKVVATSFADIGFDVDIGPLFQTPQEAVKQAAENDVHILGVSTLAGGHKTLVPQIVAELQKIEREDILVVAGGTIPPQDYDYLYEKGVVGIFGPGTVIARAAQEILHLLLDTLKEEENGGS
>NZ_AP019860.1|WP_151971744.1|8644748_8645780_-|methylmalonyl-Co-A-mutase-associated-GTPase-MeaB
MDRKKLSGWQKSVRARRRKRSAHEYIAKIAAGDRYVLSQAITLVESDSPRHKNLADEIVSGCLKIPQHNTMRIGITGTPGVGKSTFIDNFGLHLVDKGYKIAVLAVDPTSQHTKGSILGDKTRMEKLSRSDNAYIRPSPAGDSLGGVTRKTRESIILCEACKFDIIIVETVGVGQSETAVHGMVDFFLLLLLANSGDELQGIKRGIMEMADAIAINKADGENKAASEFAATRFQSSLDLFPQQYKWRPQVTTCSALTNSGIDNIWHIIEEHKELMRRHNFFHHKRHLQEKKWLHNLIVQKLKDDFYQHDKIKDILPDMERKVCDGNLLVTTAAKKLVDLHKTN
>NZ_AP019860.1|WP_151971755.1|8663192_8666798_-|protein-kinase
MTPQEKLFIQIAFNKKYIDEAAIQQAILWQNQYSQRGLSVSLPQVLLQSKLLSPEQMQDIQTEYTFRTSTIPPLSAVEKDKPALGPVSAIGSNDPVSAIGSNDPVSAIGSNKYPTNQSRESGIHRSSQASATSKTFKPGDKVFNHYTVGKELGRGGMGIVYKAYDTKLKRTVALKLLLSQQVSPVQQERFTREAEAMAQLNHPNIIKIHEIGHSPQSFFTMEYIPGKTFSQHIIENDMDLQKRLCIVRDAALAIHYIHKKGYVHRDIKPANIMIDENKEPKVMDFGLVKFDDSNLSQASDVLGTPVFMPPEQLGAGEVDRRSDVYSLGATLYQALTERPPFQGDTPFNIMFQVTTKEPIPLRQLNPDIPVQLEAICLRCLEKKKHHRYNTAKELASDLDNYLNGKPIIARPPTQMDLARKWVWQNKVKTSIFLVILSLCIFSGYYWQQAAQSAKQADVNRKDAEKKAIEAKEQRDLAELRAEEARESSYYLAVTLSNEYLKENNLAGIGTYMDKFHNEDFAHLKNWEWGWISDSVNLSQSKTILEDAGHRYCVFSSGIYQHYVAICGSGYMNLLNIHTKKSHFLDVQKGNSKNPKEQIEKVKHCHFNSDGSLLVYSSEHGIIRLYSVKTKKLLRTFRHGVVSDENEISCCRFSRNSKWLVSGDHNHVVKVWNIRTGKSVNTLVVKKRVMYCCFIDNDTKVLCLERDGIITIWDFKKDKKLKGDIGIVECEFNDLGYFKGQQILATCTAKQVNIWNVRDLLSRKPQAIFAKNANREFLDIKLYKDKIFVVDNNVIKRFDIKSGKLDKVLRDGRNFSCIAPHTNGRYLISCQAGEKKSFTSLWDLQKEHPVAIKKRDQVCFAKFSTQGNKFIVGNKRCELEVYDFDKKFVDTRNRITRGESFKHTTLSLEGLSDGIMSEKYVVLAVKKLFGRSKDLLNVYDRKSRELVYAIRKPRGVDNTKNKVEIVNCLLSPTNESQLAVVSNEYFLMWDISQKKEIFHKAIASLVKKQGGANPESLHLAYRPDGKQIAIVGEFRDILFINCEEQIPSWEYSLLVNERVNIKPRITHCTYSPDGKLLAVCSEKKTVRIYFLNPETKRFDQGNCIVLQGHDREVLCCAFSPDGKRLISGGKDQTLLLWNTDFKYDAPGKVQKASHHYLPLLALEAHEKPIINCEFDKKGTRILSADEDSVYFWDITTQNANDR
>NZ_AP019860.1|WP_151971756.1|8666872_8668171_-|M48-family-metalloprotease
MEFLDTVQKVWEIVLQYKWLTFLVAFGAVSFLIYRIVDFLQYMHVNKFTKPDDITMNEDVFKKKRQRKGSRSMKLLWKGTSSWGAQLVFIASIPFLVYWFNQKGISDGYVYMILIGLSFVLNLTLSKLFPLWTPARPYACRAFQHEKAIQPGNMAFHFWGVVSWSVPAYFFWEYFQVNGWIGSVFFIIISQLIQVVIFIYSIKKSAIPYLEYPGLSDNFKKNMQKYLKEHGMKDSEVGVLRMNMGPNAFATSLAGYKQIVITEELIQGYKDPTNPDFTLKLSEDTIEAITSHEVGHIRHHHVEKGIAMGILISSAVTIAVYHLFSADPSNYVLFKEGTSQQLLLYWGQCIFNTMLVYPITFITLLVSRRKETQADTYLLNTNGCKNGKDFFHQIRHIAPVNNLGLWHSCNGTHPAAHEREQRMLEWEKEHCK
>NZ_AP019860.1|WP_151971757.1|8668180_8668699_-|YiiD-C-terminal-domain-containing-protein
MSKKFALMRDLTTKAKESKFYLSILNKLMWTAIPFNKPHRFTISMIKDDEVRVTAKYRKKNLNHLRGIHACAIATIGEYASGILLISNLDPAEYRLIMAKIEIDYVYQAKSSITAVASLSEEEKQKNILEPLQKEEAVFTTMEVPIHDMQDNLIATVKVKWQIKLWKSVRTK
>NZ_AP019860.1|WP_151971758.1|8668924_8670271_+|DUF2817-domain-containing-protein
MYKGLILFFTVIAFVFADDNNNVHINSLKERYAVTIHNNKDIKKIVGEGIELDCATCRNNELQVYATPYQVNLLKNKGYKVVANPVIIGKNTRDASYHTYATLTAELQKLANDYSDIAQLHTIGKSVEGRELWIIKISDNVEQNEAEPEFKYISSMHGDEVVGKEMMMYLINELLTNYGKRDDITRLINETQIWIMPSMNPDGTEAQRRYNADWVDLNRNFPDLEDDKKNTPDGRATETQLMMRFNEEHNFVLSINFHGGALVVNYPWDTKSGDAPYIELVKYLSLGYSSRNKPMYENGSFPQGIVNGYNWYEINGGMQDWNYHWYGTLELTLEVSDVKWPNADKLAGYWADNKESLLWYMSQTHKGIKGTVRDAATGEKLRASVSVTGLNSTIKSGALHGDYYRVLLPGTYDLRFSAPGYQSKTVRGVKVQEGEFAATVLDIELTKE
>NZ_AP019860.1|WP_151971759.1|8670511_8674603_+|HAMP-domain-containing-protein
MRWKKLRLVIVFLCITTTLSYIFYSYRISYVDKNWESYRQNFLYDGLFDVQQRFFSLEKQLRHKLDYLINTTELQSCFRKHLKARSQRQRETTKTALFEQLFRKDVSKVIEPYGIAVFASYKNTPLIAWKNWSIDLPFSVLNEALSGVRTSYILNSQEKIYTMLCCFVPIFDNGKCLGTFAISTRLNTRYLLSHRYIKTQYFTENDLEKELSARHIQEIAIHFTQKNDFFEDGLQQPFFNLNMEHMGWVILVSKSKETVLENIYKNGRVIRNATWGVFGFVLLILFLYNIYCSTFRNTTKLFLSIGILIAARYIFIIISFPIELFELLNLPIEFCSESTMIFASQIYHFELSGTPIDFLLTNLFLFLGCRLLQEYGVGKINRNRFTQTSAFKIGMLCVFCLAFTLSYYFLHTATRSIVEDSSVKFVINDEIIPSSPQIILMLAVIFLGLALVLLNAQVIRYCIRLYEGWDKYYLFVPLPFVCYYSVLPETNNFYLLMSCMAGAVCFCWAISLLVFYFPKVQTIRRTVILFFVCLTIYPIMYYESKAKIRDNISSKQEEKAEIASNYKSKDFIEQILDNQLWFNKELIKSLESFNDDAAFLLWANNTILNSYFRNIYISVYVKVPQPLPLGLDANRFFYWGDDEIYYELSSFSSGVAKEQWYEAMIKKDLPHDRLFVLAGVSGYGYSTQEKKSLLTLGGKPIFKGEEIIGYVAILTMYEKISQMHTNYLAYGFSQESIRDSLLRAYFDKEKLIETSIPYMTKTFSPPPVVLENVGKGNTSVWLTQNIENVPYDCFYFPHEIQLPYYDENDDKLPKYQVRKIIGLIGYPVPSTIFMIFYFLQLFFAGLLCVIVPNFLWNGAHTIIRENKISNLSFERKLLISFFTISAIPVLLLAIYSREHAVQKVHENYRHTLTNYLEGAYTAMEEEDYLLQPFAENGNIISYNLGTKFCEQWHKENRQILNVYMRNKIFVSNGRDFFQTELLSERLPGEIYYNLILLKRDTFIHIQDTGFIVGYKAAFFHDNARVQNLILSIPMVYEKSRVESEITSILVNIITIYVICLLIIIVAAFLLINHIVRPLKQLITGINRVSTGDLAVEIPRTSNDEIGQLIAAFNRMTKDLEVSRHKLVQAEKNAAWREMSRQIAHEIKNPLTPMRLSAQHILRAYEDQARQFPVILQRGISNIIEAIDSLAKTATSFSEFAKFTKPNLEVCNLEDILLTCVNLFEEYKEKDITTQLHIENEIPHVFVDPHQVKRVFINLVTNAIHAMEDKEDEGHINIICNYSSPQTYVVVEVRDNGCGVPEHVKPHLFEPNFSTKSYGSGLGLAITKRSIENMNGEISIESKEGVGTTVFVKLPIQQMSCEDQ
>NZ_AP019860.1|WP_151971760.1|8674638_8674911_+|hypothetical-protein
MAKQCLYCGVSDEIIPVTFVDNVCKRCIRIQCFQMIRDGLFQQIIERDIQYAESMMQIAKEFKERNPYEYLQIAEKVRQDFEEYMTLLLW
>NZ_AP019860.1|WP_151971761.1|8674915_8675371_+|hypothetical-protein
MQKCKKIFQTMLLIVGIGAFLMMFVLFFYTQNNARTLYRFKEHGKKITATVVEKSCNSFLGYKTYTVAVKYKKQTRHITRFISEKTYNTLHLNSTTEILQNSENTETILFASTDKKNLKITDKKTIVYILLLIGFVCFVTHSILGNLGHDR
>NZ_AP019860.1|WP_151971762.1|8675360_8676800_+|peptidase-S10
MTDKQDNENKPPKFQEEELVCQEKQIDFRSQILRYQATTGRLPLKNKDQEIDAQIFFTYYQKTPSDKQRPLTFAFNGGPGSPAIWLHLGALGPKKVQMTAEGFFPQLPFKMVDNSHSWLNETDLVFIDPVGCGYSEAKDEKTQEKFFSPNGDIESMGEFIRLFLTRFERWSSPLFLAGESYGAFRVAGLAGHLFHRGITFNGVMLISGALNFYTLHIGPDYRLHDLPFVLILPSYTAAAWYHKKLSDDLQKRDLKDVLQEVEKWAKTEYTLALMEGNELTTENYDNIVDKLCMYTGLQPQKVREVDLRVTLQEFCHNLMKPENTVVGRLDTRFVGLNAYESVVGSLTGDPSLASIIPPFNSCFYQYVAEELGYKSDLTYQNLTGVTSWKWENGHADTSQALQKAMSLNPHMKLYVGIGYYDLATPYFAMDYTLSHMRLDASRHANIAYHAYEAGHMYYINENSLQKFYDHIAQFITGSL
>NZ_AP019860.1|WP_173013664.1|8676886_8677396_-|protease-complex-subunit-PrcB-family-protein
MFYYRNILLVILCLCVIGCNPKPENTPDKSQNNENNTQQDNNTQEKKVEFTTISQGANCGHNEKKDYVITNEDEWKKLWAQVHANMEPKPELPKIDFEKETVIAVFKGQQSSGGHSINVAEVMIKGDACTTQVKEVNPDPGGMMSMGFCQPYHIVKVPKMEAKVSFKRK
>NZ_AP019860.1|WP_151971764.1|8677586_8679584_+|oligopeptidase-A
MNNNPLLIEHGCVDFSLLKAEHVVPAVEKTIQDCTQIMEKITATENHNYETLVAQLDIMSLKIDRLWSPVTMLNFLANSPEIRTAYNEGRQLLTQFETVLRSNSMIYNHLENFSKDSLNTEQQTVLENYTRDFRLHGASLQDSAKERYKEIVLELSNLQSTFGENVLDSTASFQLLVKDENELAGLPQSIKASLKEEAQKSGQEGYLCTLQMPVVNAILKYVDDENIRKQIYMAHSKRALEEGRDNRPLIKEILTLRKELASLLGFETYAHLSLAKKTAESPEEVLEFLYSLEEKTSEPAKKEFAELSEFKKQTTGGELHHWDYSYYLEKLRKQQLDFSEEDLRPYFSIDSVLKGLFEIVEKIYEVEVKEVEAPQCWSSEVRYFRAHSDGEMLGEFFLDYHPRKNKRGGAWMQDVVGRSRNENGYEKPIGLIGGNATRATEDTPALLDHREVVTLFHEFGHMSQFLFTKCNEYSVAGINGVPWDVVELPSQFLENWAWNKDALKMFAHHYETGEEIPDDLCDKLIASRNFHRATQIRRQLEFGLMDMHLHYDYDGKPLFEFSEEIHNKMSFFPLLPDTLFLAAFNHIFAGGYSAGYFSYKWAEVWEADAFELFREKGIFNREIGRSFRQNILEKGGSENPFVLYERFRGRRPQQDALLKKYGIAN

Crispr_ID: NZ_AP019860_45

• CRISPR_ID: NZ_AP019860_45
• CRISPR_location: 8882668-8882808
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_45

Consensus_repeat	Method
CAAATACCGGTTGACTTTCGTTTCCAACACCGCACAACATAAAT	CRISPRCasFinder

spacers of NZ_AP019860_45

>45.1|8882712|53|NZ_AP019860|CRISPRCasFinder
TTACCTCTTACAACGTGCGTTGTAGGGGCGGACCCTGTGTCCGCCCGTTCCCC

CRISPR arrays and Neighbor proteins around NZ_AP019860_45

CRISPR arrays

The CRISPR arrays of NZ_AP019860_45

>merge|NZ_AP019860|45|8882668-8882808|CRISPRCasFinder
CAAATACCGGTTGACTTTCGTTTCCAACACCGCACAACATAAATTTACCTCTTACAACGTGCGTTGTAGGGGCGGACCCTGTGTCCGCCCGTTCCCCCAAATACCGGTTGACTTTCGTTTCCAACAACGCACAACATAAAT

>NZ_AP019860|45|37|8882668-8882808|CRISPRCasFinder
CAAATACCGGTTGACTTTCGTTTCCAACACCGCACAACATAAAT	TTACCTCTTACAACGTGCGTTGTAGGGGCGGACCCTGTGTCCGCCCGTTCCCC
CAAATACCGGTTGACTTTCGTTTCCAACAACGCACAACATAAAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151971900.1|8868360_8871411_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971912.1|8877986_8878781_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_151971914.1|8878858_8879713_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971908.1|8876912_8877242_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013681.1|8873706_8874627_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971916.1|8879891_8882597_+|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl|CDD|234570
NZ_AP019860.1|WP_151971934.1|8892160_8894944_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971924.1|8885292_8885526_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971920.1|8884039_8884876_-|phosphatidylserine-decarboxylase	unknown	unknown	gnl|CDD|234591
NZ_AP019860.1|WP_151971926.1|8885536_8887210_-|DUF885-family-protein	unknown	unknown	gnl|CDD|377577
NZ_AP019860.1|WP_151971932.1|8891639_8892173_-|hypothetical-protein	unknown	unknown	gnl|CDD|276809
NZ_AP019860.1|WP_151971918.1|8883042_8884038_-|glycosyltransferase	unknown	unknown	gnl|CDD|366154
NZ_AP019860.1|WP_151971930.1|8889069_8891526_-|hypothetical-protein	unknown	unknown	gnl|CDD|225926
NZ_AP019860.1|WP_151971902.1|8872249_8873638_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_AP019860.1|WP_151971922.1|8884942_8885206_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971936.1|8895152_8895623_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971901.1|8871556_8872237_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971906.1|8874665_8876798_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971928.1|8887230_8888988_-|sodium:proton-antiporter	unknown	unknown	gnl|CDD|224671
NZ_AP019860.1|WP_151971910.1|8877409_8877982_+|hypothetical-protein	unknown	unknown	gnl|CDD|274357

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151971900.1|8868360_8871411_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.21694e-77
NZ_AP019860.1|WP_151971912.1|8877986_8878781_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	7.74494e-30
NZ_AP019860.1|WP_173013681.1|8873706_8874627_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.16777e-87
NZ_AP019860.1|WP_151971916.1|8879891_8882597_+|phosphoenolpyruvate-carboxylase	gnl|CDD|234570	PRK00009, PRK00009, phosphoenolpyruvate carboxylase; Reviewed.	0
NZ_AP019860.1|WP_151971934.1|8892160_8894944_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.19283e-78
NZ_AP019860.1|WP_151971920.1|8884039_8884876_-|phosphatidylserine-decarboxylase	gnl|CDD|234591	PRK00044, psd, phosphatidylserine decarboxylase; Reviewed.	2.17363e-101
NZ_AP019860.1|WP_151971926.1|8885536_8887210_-|DUF885-family-protein	gnl|CDD|377577	pfam05960, DUF885, Bacterial protein of unknown function (DUF885). This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.	0
NZ_AP019860.1|WP_151971932.1|8891639_8892173_-|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.11423e-05
NZ_AP019860.1|WP_151971910.1|8877409_8877982_+|hypothetical-protein	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.59362e-08
NZ_AP019860.1|WP_151971902.1|8872249_8873638_+|alpha/beta-fold-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	6.13868e-13
NZ_AP019860.1|WP_151971930.1|8889069_8891526_-|hypothetical-protein	gnl|CDD|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	1.91754e-13
NZ_AP019860.1|WP_151971906.1|8874665_8876798_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.83816e-83
NZ_AP019860.1|WP_151971928.1|8887230_8888988_-|sodium:proton-antiporter	gnl|CDD|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	8.54798e-30
NZ_AP019860.1|WP_151971918.1|8883042_8884038_-|glycosyltransferase	gnl|CDD|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	2.31149e-38

Protein sequences

>NZ_AP019860.1|WP_151971916.1|8879891_8882597_+|phosphoenolpyruvate-carboxylase
MKKDVNAQGTNKVSADLYFVMECFQHVLQNLGEDEIAKALPWLCDENAPVELSNDPCILNKQIQAFSIAFQILNLVEENAAVQHRRQVTDSEKAIRGSWEETFRGWQKQGIEPQQMAELISSLNICPVLTAHPTEAKRITVLEIHRELYLLLVKNENTMWSNLEREAIRREVQALLERWWRTGNVNLEKPQISDERDNVMHYFSHAFPLALQMSDQHLQNVWRNMGFDPKLLCRAEHYPRLHFGSWVGGDRDGHPYVSADVTASTLRKHRQAALTILRDKLVDLAKRLSFSALRNEMPQSLQDFITQRSEIHGDAGQKALKRNPKEPWRQFVNLMILRLQNTLDENDNNDLVYLSSQALQEDLQLLRSTLAEVGAQKVADHLLFPIERQVQCFGFHLAKLDIRQNSSYHEKALDQLLKFCGETQQHYSEMNEEQRIEFLNNELSKNRPFTLQGSKCGKEADELLAYYWEVKKYTELYGYDGVGSFIVSMTRGVSDLLVVYLFLREVGLLHSPIRVVPLLETIEDLQAGEKILQAFFTHPLTQERRKYQDGFYEVMLGYSDSNKDGGILASRWNIYQTEKKLSAVAAKHDVKLCFFHGRGGTISRGGGKYHRFLDSMPAGSVSGHIKLTVQGETIAEQFSNPMSSIYNLEMLQAGVARQAMKSYLGKTHEDYPTAAMNKLASLAFTHYPQLVNHDHFIEFYSNATPIDVIEHSKIGSRPARRTGKRSLGDLRAIPWVFSWNQARFNLTGWFSVGNALQQLQTESPDEYKQLKEVSESWPFLFYTLIQVETNLLNADDKVMQMFANLVGNKDAQTALMDVLLYDYKEALKQITHMFDAPVSERRTRQLENIARRGPILVALHELQVKKLQEWRAQSQSKEAEKLLKDLLQLTNAISGGLKNTG
>NZ_AP019860.1|WP_151971914.1|8878858_8879713_-|hypothetical-protein
MRYICFLVIFLAVGCQSFNQEKYDAALKVVESGLEEEFTQKKYPQAAILARAVLDAEPDNGRALEIKKIVLQEDPRLDILFNKATLGSNYTDRIASDGGNSIVWGILLYLPNRVLDVLDLLNVETGVSAGVGVNINMTEYGALGAQISAGEVLIGLDRRHLSSRASIRESVEIFPFELGAMGEAHASTGGARAIAYTKAGIKSPLDDVYQKSRDFWAIGAEIQLIPMAFKVGIHPVEMVDLLAGFFFIDILNDDLGTSQSIDLRGDLEANMRTLMQQTAIRENR
>NZ_AP019860.1|WP_151971912.1|8877986_8878781_-|leucine-rich-repeat-domain-containing-protein
MRKIKGKSLNKIEDNTTYFACIFYLSEGKHTFKNCSFHDCSFRSKVILENPRGCEFVNCGFSGDLELDLSRANLDEIPEYVFSLTSLSALDLSSNNITCIPRDISKLVHLTHLWIFENHITHIPPEIGHLRKLHYLNASINKIKAVPREMGKLDNLIELRLRHNQMIEFPLAVTELKNLVYLSLTGNRIRNIPPQIKHLTKLKKLWCDNNPITEVSEEIKNLQNAVLIDLLWIYFSEKQERFLQEAFPDSKLLMTPRDSYFFEK
>NZ_AP019860.1|WP_151971910.1|8877409_8877982_+|hypothetical-protein
MVESLSKIDTQWSEMENIAHDNGPSMLAEYLAAKYYDALAAKFKRYAPRLDDLKTYELASDVLYDLIKNDYRGVKRLSRDRGHLRGLFFRIIKSKLFEVGKQKKTSTFEGFEKETNVDEWVNIYIDFNDSVEKLKEQRPKLHLPFSLFYLEGKKIAEIATELGIKENAVKQRLYAARRFLADLLQEYKSK
>NZ_AP019860.1|WP_151971908.1|8876912_8877242_-|hypothetical-protein
MKKLFILIAIIASGCQSFPSPEYRSAVSFSQFSNDFNFSESSGVFSGLQLNSPSRSIEKSNRSSLWDSLGLSNTKTNSSSVEFGVMNNSSTTSMEDYGTIGAPNSLFGR
>NZ_AP019860.1|WP_151971906.1|8874665_8876798_-|protein-kinase
MHKKIGELIVEEGWITPEERDEVLAMQQEKRRSGAANVETLLGKLLEEQGLVTPTVIAEILDRQNNSFRDKFERLITEEETFDFAGYKVEQFIARGGMGMIYRVSSPKFRGPLVMKIMDLSTISEKVKKRFQREISIILRLSHPNIVQVFDYGELDGIDYLVMEYLEGETFDQIINNSSLHYSFWCQKFLVLLSAIQKIHENGIVHRDLKPQNIMYSKYKQFVVLDFGLGKIKDEITSLTSIEILGTPSYMSPEQTVPTTKQTFQVDIWSLGVILYQLLTQRLPFDEQTKRDLLHAIRNQEIVSPQVYNPEIPNALVEVCKKALNKNPENRYAQVKDMADALKKALAQKTSKPQKSLRYQKMMIYGLGCLTLAVMITFYQQVIVKRQKQQTPNVQNTNQPSANRQTTNDENTDGAKPSLHKQGSDTVNLEQGAHEKWRVRLEKMQREYPKNSRKVKDWQTFLRNFAQDNPYTDEDDKMRQTARKRVEVLRKNIHKKKWHIRLGKMEREYPKNSSKVKDWQIFLRDFVQDNPYTDRDDKMRQTARTKIRTLQTYKKKIQQIMAQFSQVEKTPYVLINERIEAWQSFYDKIQRDIPYFFQDNHIRQKIKARILELNNEKLRNSQMLVILIVQNKEILAKCTAILQKEGFRTDVLNIKTSKNECIYYSRLESTPTLQQVQHICNIVAKFAHRKLHIKKIKIADKKEIRLKISD
>NZ_AP019860.1|WP_173013681.1|8873706_8874627_+|serine/threonine-protein-kinase
MHSSYFEKKCDCEHTIEIEMSQNTDFLCINCKVCGGNYLFKISQYIVNSMLGSGGSGQVYLATDHNGKQVALKTLAHPTQANLKHFERECSMQQKLQHKNIIQLLDQGNHGDLYYLVMEYFPGQTFDEIITERGYLTPREAIKIILSVLSGLAYADKLNMVHRDIKPENIYITDDGQVKILDMGLAKIVDETYGLTDAEAIKGSPYFMSPEQLAATKTADIRADIYSVGATLYNALCGVEPFSGHKTILQVAIAKKENKYQSLKDYDIEISPELIRIVEKSMALIDSRYQNPQEMMQDLYDLYKNL
>NZ_AP019860.1|WP_151971902.1|8872249_8873638_+|alpha/beta-fold-hydrolase
MLNKLILFLLPSLLCGCFVNIPFQYTDIVQTENSLPKFQKLTKDNNIIYQSSFGSPRQLGMTSTSFIVLNSYDDIFEDQIPGKAGVDVQRANYHELPADFLGAPVGHKPLQIKGRIVHGSKKAIIIIHGIFFSKRTYFLKEYVRVAQEQGFSVVSIDMRGHGESLSSEMSVGIYEALDLCYLAKRLKSDYGIEYVGLIGFSLGAHTTIRAMYESSQEAALSGNAPIIDAGVAISPPCDMVKAFDDLKQHGFGRTTSNFFHGLFLSRIEALRESKFIQQDIQINEFDEYINQIILPRYQANRNATKSDENLQFLREKIYGEEYKYLDQKTQEYISKFKSMKNHKDLLREASTHDLLPKIKLPLLIIHAQDDTTIDVQHIYEAADIINKQKLNNIMAIVVPDGGHISLHHVDPNWTYSTVYGFHHYCAGISPQNFKPIREVSSLWYYFDRVLYPSQLSLSWTLF
>NZ_AP019860.1|WP_151971901.1|8871556_8872237_+|hypothetical-protein
MLQKLMLLTLALLFLQSCRVAPIQMARVTQIDSYKQTYNFKDESQAARALEKLMGQKNWEILIDYLGSSEYFQELQSKNIFVKGSFVMSITLNPKDHNRFLVEGFGRYYVVRNKTNEVLFSADYRIIEKQHTIDDFQKKKVLNVDVQHSMIRHFPTEGEKNFYHEAPFNMNIFVTSTTDGVYTLNYDKEHELVIDGEVVGNMYFAKSLAQQKLIDLRDMGYVKNDY
>NZ_AP019860.1|WP_151971900.1|8868360_8871411_+|protein-kinase
MTEPNNNNENDINNKPKNTSYIDGEATAFDINKPTTPSNATPQYISGEQTMVPNDDTGTSTEKEISTFAAIPVDQEQSSIPEAIVVQEQSSIPEAIVAQEQSVFSQNQEETVNPESHTMERLPFSGAVEVQEQTINPDDIVAKHPPKKHVDIPNPKETNNIVQEDTLNPDDMTVAYSKDITVPYSEDVTVPLQDNSNFETAKTEALNKNQTQVTNIPQPNEVTNTDDISDRLSAVNIAKKETSKSSRTDPQSHKMENTSRRENVTPPETKKYYQKPQLPSNYQYVKPISKGGQGEVWLVENTNMHRYEAVKILSNIGESGLERFRREIHYMAALNHNNIATIYYANPEEAYFIMENLPQGTFEVVTKDNAMPIEKKVRLLKEVLKGLSFAHQKGFVHRDLKPGNILFSDDMTPKITDFGLAKIQDESDLTKSQAAFGTPSYMSPEQWENAKDATSLCDIWAIGIMLYEIIAGKKPYSDLSSYQLMYAVVAETPIPSPYQNHEEPLTPQQKMLESICLQALAKNHNERYQNAEDMISDIRQYLGDEPSMISQEVYKPKSWLSTAVASMIVVMLFLGGYVGIQLYQLNNMQKEYAKLTPQSTLQDWQAFVDKFSANIIYFTEDNTMLNAAKNHVAQANVKQQNWDKKLNAMRAAFETIKNAKQDSPATIEQWKTFLKKFSQNNPYSKQDEQMYKIASDTVENYAKDLQNQKLKAQKLDREKWRKRSQQMQTQFKTIAKQKASISEKIALWENFLKKNKAPNPYTQQDQKLKKEANTMIASLRKELQKYKKQQAQKTAQKKQWYSQLQRMKKSFETIRKSRRGLQEELSLWKKFTKTYAKENPYTKTDNKMRSYAQNRIKELRLAIENWQNQLAKMQSTFAQLQKKRASVSEWQVFLSQFAQNNPLSQEDERIKNQIRQYLDQIQNNAKYKIIIISKNNKVLKTVQSILAQNGFKVDVLPITARNNEIVYYTVEEPTPNHIMFRVKLIQKIIQKQINNKFSLQRKKLRNKEFEIKIKIK
>NZ_AP019860.1|WP_151971918.1|8883042_8884038_-|glycosyltransferase
MISIVLPVYNAEEHIKNAIDSLQRQTLQQYELIIVDDGSRDHTAQFIRSYNDKRINVISLEKNRGIVDALNIGIQNATSAYIARMDADDLCHENRLQQQYDFLRENEHIGAVSCRVRCETTQHNKGMQEFVTWTNTLLSCEEIYRNRFVETPLIHPSMMFRKSLIDKHGGYSHDFPEDYELWLRWLHHGVRIQKLPEYLFTWNDPPQRLTRTDPRYHESQFYACKTHYLAKWLDKKGIGEVVVWGAGKKARQYAALLRDYGVNIQGYIDVDAKKIGKTIHQKPVYHYEKDFVQYSDFFVLSYVGNRGIRDKITAYLEERGLTNGVDFLLMA
>NZ_AP019860.1|WP_151971920.1|8884039_8884876_-|phosphatidylserine-decarboxylase
MKYPKLLLLYLLPKNLLSYIVGILTSLKLPQFILKPLIATFVRAYKVSMNEAVPAKYRTFNEFFTRALRPECRPIDEDTHSIVSPVDGIVGYSGEIKRDTLIQAKGREYSLDAFVANKEYAEIFRGGVYMTIYLSPSHYHRIHTPVAGKVTSLNYIPGKLYPVNPFAINNIDHIFSKNERLISIIESDTAGKVAVVKVGATNVGKIKVVYDSVTSNNFWRKGVFKTYEDVNLQKCEELGRFELGSTVVLLFEKGKVKLTQDTPESDVLLGQKIAEVCK
>NZ_AP019860.1|WP_151971922.1|8884942_8885206_+|hypothetical-protein
MRPFISHNSKSMSLEELFFFAMMYSATIHVTHKNAHKNRYKYIFCTGKISVGGEKTIAANIALTLPNTEAKTTKVLRIKRVSIDIFP
>NZ_AP019860.1|WP_151971924.1|8885292_8885526_+|hypothetical-protein
MLRLLAIFSLMGLIFTIFTNFEAQEYTDIKFSSHGEKEYYFMQVHPEEQVKESNLGERELPIIRTHYSYSYKNSNSW
>NZ_AP019860.1|WP_151971926.1|8885536_8887210_-|DUF885-family-protein
MTEQLSQLFDEIWEWQMETDPLSATFYGDHRYNDRLPSLRLEDIEEQATKKREFVEKLQQINVDELKQTDQINHKIMHRLLDEKLQSFHFNMHLMPLSQVHGFHVYLPELPNYTVLRAAKDYEMYITRLQKIPQYIEEHIELMRVGLQKGCTLPKVALSSCTKSISTQAKQKVDENPLFQPFLKIPVTIENGQELKESGEQAVQEIQQSYQNFLQFLSEEYITNTREEIGISAIPNGKACYEFLVKSQTTLDVTPQEVHDIGLREVERIKAEMLKILEQVNFSGDLEQFCKFLHSDERFYAKSEKQLLAEVSFILKTMDGKLPQLFSHLPRTPYGIKKVPDQVAARMPAAYYMPAPGDGNGAGFYFVNTYNLESRPLYELEALSLHEAVPGHHLQIAIQQELTELPKFRRFARFLGFLEGWALYCEKLGKEIGFYEDPYSDFGRLSFEMWRACRLVVDTGLHYFGWSRQQAIDYLSSHSSLTKHSVTVEVDRYISLPGQAVSYKMGELKVSALRKLAEEGLQEKFCVREFHHVFLKEGAIPLNILEENIKSYVAQGK
>NZ_AP019860.1|WP_151971928.1|8887230_8888988_-|sodium:proton-antiporter
MQTFLKNATTFFSNAGFIAFFVAVSLSFYVGQFTSPTWTTTRVTIDAKQDDSGNFYYIYREKKQELSEPVSEDKAVLSAKNLQQLNAKGLAPSITEEVVFAVKDGKTLYYQITAKRHWQIWSLLPAFIAIVLCWWTREPITALSSGVICGVLLVGDIDVFTSALLPNIGTANAATILILYLWFLGGLLGIWAKTGASLAFAEYVTKKFVRGPKSAKLVAWFLGVIFFQGGTISAVLVGTTVKPIADKEKVSHEELSLIVDSTSSPIAAILAFNAWPGYVQAFLYVSGVAWLATEQDRVDFFFRSIPYSFYALFAVISTFLVSIDKLPSRTLRAARERARDTGALDAPGAEPLSSKELELAEVPGNYAPHMIDFLLPLFTILGIAIGTYIASGTPQILSAFGISLVLSMFLACFRGMKLRDVIEGMANGWKGVVLGSVILLLAICIGNVSKNAGGGAYLVDLLGSETPYYLLPAILLVICIVISFSTGTSWGTMAVTFPLGMPLSYAIAVNNGLADPQFYMMVCFATILNGSIFGDQCSPISDTTILSSMCTGCDLMDHVKSQIPVAVTSMLLALICWTVCVVVYA
>NZ_AP019860.1|WP_151971930.1|8889069_8891526_-|hypothetical-protein
MKYCIFIYILCFVFFVGCGDDIDLDGRASQNSTIQISDDDNFVVAINRIASADSGVAFNRLSDVNGSLSILRVANDENIKVDEITVGKDPRSVSINKDFTRAFVSNGQDNTVTAIDISAVPGGGTAAVLATINVGSEPRGTALTPSGEKLYVANYGEGTVSVIDTATNTVIRTIELEFFGTNIDPFVLANPYAIGISDNGDDADEDENVIVADFFGRPIEQLPKDSREGFDNGKEGRIAFIDVSNDEILNVITLSPVRDTGFTANRIPFQQTVFRVSGGAKGNAPQGAFFNQLHTMTFRDGTANIYLPSIGASPEPPVNFNVNVQSLIGVIQTGANAEVANQHFNLNARFKNEREPIPPFDAGNDFRLDRTFSADTIAMAIEVDTALFLSRAGAFVTKGFFNGDQIAFDVPAAFRIPVGNVPNGIVMNSDATRAYVNSDVESTTTVIDVEAAEQLAKIENATLPPAGTEQHQILIGKLAFYTGMGLPAEDLLNQNVRDIDTHRFRNVASKDNWSSCASCHPDGLTDGVTWIFGTGPRQTLPLDASFSFVDPDNDRRVMNWNAVRGSVTDFNNNARNVQGGFGFTPDAQRVIDDQGQPGDVEDFDEVFNHGPDENTFVENLGRIGISDSLNLMTLYTQRGIRTFNRPTNLDNAAVLRGRDAFEIFCVDCHSGDKWTTSQILWDTPLFDIGGNQLDDGVVVIGPARSTLEFNENGETFTIINQNFETFDPNNPIEVRGNAQPALGQNVSFNPPSLLGVRHTSPYGHNGRAERLEDIFLPRVDDGLEHSTFGANDAQIRDILEFLQAIDEAEAPFLFLRKK
>NZ_AP019860.1|WP_151971932.1|8891639_8892173_-|hypothetical-protein
MLQIEKFVISYPNHIDIFLLRGRIYEEKQQLDLAVKDYQKVVQKIDNIEAYYRLANIYYNTKKYLRVVDIINKIFATRLKIHPGAKSNFLFFRGVARFFLDRFQDSLNDFSQIKEKRKYLKSKDASYLYYYQGIILLQQKKYSEAKKSFLIAAKGLKSSSQQKSIQRYLQQIEKINK
>NZ_AP019860.1|WP_151971934.1|8892160_8894944_-|protein-kinase
MTLNQKSQQIEKNKVLIVEDEFAVANFCAMALNEAGINARIVQDLSQVERDLQTFSPHLILLDLYIPDFDTMEFIRHLRRQENYVTIPIILISAHDNPDNRLCAYDAGADDFIEKPVHPDYLISIVNSRIKRLRHIKSVIELQQIERGTLPTQKLGAPEKLKHHTGSRPQSTSIADDILCKLLLDFDIVSAEEMQDLLRRQSEMENDEYFVRLYDLILYLKVVDEHTLCNISLLKDIGGTSLIEGYQADEMIAEGGMGVVYSGYETSTQKRVAIKVFYDRDNTHLIDLQRFIRECDLAQSLDHEGITKAYKFGEINNIYYIVMEFIDGVALSEKIKEQGYLVESEALQIFGKALQAMSFAWEKDIIHRDLKPDNIMLTVDGDVKICDLGLAKAINSNAQLTQDNVILGTPSYMSPEQCMGATLDYRSDLYSLGVTLYVMLTGKEPFHGNFLEVAQGHMTEVPPQPKVKLSEPIHKFMYQLLYKKPAWRCVSIKGLLRDFDDVQRGRLPYTYRLRATKKTLRKQLYVLATLVVLVFVVLGSFWSYEKFYHLRQRNVILAHFSNKQFAKTIYLSYGYLLNNPNNIQIQKIRAQSWLKLRKYQQAVKYFAEVVVQSPNEDEILGDYAYALYYLKRFDEAQRQIEKVLLTQKSADHYYLLARINWQKQRSGLSKKYLKKAIALTPEYWQAYYLLGIVDDVKWFNTLYEYLPQDCPVELRQWIYYVNGVLLYRQHQYDKSKKQFLFAQAFGETKEINQYLAAIFCHKNNHDKTVQLLGTERLSFAKTLENIHTMIDIPALYFALREDLLAHYLATAFLHTNSPQKALFYIKKALKQNPKEVKYLKTSSDIYHKLKKYQKSIAQLHLILKYAPDQKYQVKLHKAKNLIALHKWQESLILLNELVKVKYNLRQVMPLQIEALIYRKNTKLLCCR
>NZ_AP019860.1|WP_151971936.1|8895152_8895623_-|hypothetical-protein
MTKYDFAAIVFLVLSLILFVAGTYHQIYQRKMQLLCRGKLNHLGSVYFIYRKNTNNDPKELTSWRQKLQKYSPSTDFGVCPCENTTVFSYQLNLSGLFANKGEEHILFFDSHPTQKSHCKTFTEDLVAWRHLQGANFLLSNGAVVHYKKNNFPQKH

Crispr_ID: NZ_AP019860_46

• CRISPR_ID: NZ_AP019860_46
• CRISPR_location: 8927015-8927453
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of NZ_AP019860_46

Consensus_repeat	Method
AGAAATAGGAGAATTACAAAATCTT	CRISPRCasFinder

spacers of NZ_AP019860_46

>46.1|8927040|44|NZ_AP019860|CRISPRCasFinder
ACCGAGTTAAATTTAGACTGCAACCGAATAACTACCATCCCTAA
>46.2|8927109|44|NZ_AP019860|CRISPRCasFinder
GAGACCCTTATCCTTGCCGACAACTACATAACAAAAATTCCACG
>46.3|8927178|44|NZ_AP019860|CRISPRCasFinder
ACATTTCTGAATTTATGTCTAAATAAAATAACGATAATGCCACC
>46.4|8927247|44|NZ_AP019860|CRISPRCasFinder
GTTGAGATGGATTTATCTTTCAATAAAATAACGATGATACCTCC
>46.5|8927316|44|NZ_AP019860|CRISPRCasFinder
GAGGCTTTAGTGTTATATAATAACAACATAAACGTTATTCCACC
>46.6|8927385|44|NZ_AP019860|CRISPRCasFinder
ACTCGTCTGGATTTACACGAGAACACGATAAAAATTATTCCAAA

CRISPR arrays and Neighbor proteins around NZ_AP019860_46

CRISPR arrays

The CRISPR arrays of NZ_AP019860_46

>merge|NZ_AP019860|46|8927015-8927453|CRISPRCasFinder
AGAAATTGGAGAACTACAAAATCTTACCGAGTTAAATTTAGACTGCAACCGAATAACTACCATCCCTAAAGAAATAGGAGCATTAAAAAAGCTTGAGACCCTTATCCTTGCCGACAACTACATAACAAAAATTCCACGAGAAATAGGAGAATTACAAAATCTTACATTTCTGAATTTATGTCTAAATAAAATAACGATAATGCCACCAGAAATAGGTGAATTACAAAATCTTGTTGAGATGGATTTATCTTTCAATAAAATAACGATGATACCTCCAAAAATAGGAAAATTACACAACTTAGAGGCTTTAGTGTTATATAATAACAACATAAACGTTATTCCACCAGAAATCGCACAACTGCAAAAATTAACTCGTCTGGATTTACACGAGAACACGATAAAAATTATTCCAAAAGAAATGTCACAACTAAAAAATCTC

>NZ_AP019860|46|38|8927015-8927453|CRISPRCasFinder
AGAAATTGGAGAACTACAAAATCTT	ACCGAGTTAAATTTAGACTGCAACCGAATAACTACCATCCCTAA
AGAAATAGGAGCATTAAAAAAGCTT	GAGACCCTTATCCTTGCCGACAACTACATAACAAAAATTCCACG
AGAAATAGGAGAATTACAAAATCTT	ACATTTCTGAATTTATGTCTAAATAAAATAACGATAATGCCACC
AGAAATAGGTGAATTACAAAATCTT	GTTGAGATGGATTTATCTTTCAATAAAATAACGATGATACCTCC
AAAAATAGGAAAATTACACAACTTA	GAGGCTTTAGTGTTATATAATAACAACATAAACGTTATTCCACC
AGAAATCGCACAACTGCAAAAATTA	ACTCGTCTGGATTTACACGAGAACACGATAAAAATTATTCCAAA
AGAAATGTCACAACTAAAAAATCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151971997.1|8935805_8935994_-|50S-ribosomal-protein-L32	unknown	unknown	gnl|CDD|237038
NZ_AP019860.1|WP_151971964.1|8917109_8918549_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	unknown	unknown	gnl|CDD|376743
NZ_AP019860.1|WP_151971972.1|8922550_8922859_-|50S-ribosomal-protein-L28	unknown	unknown	gnl|CDD|234736
NZ_AP019860.1|WP_151972001.1|8939166_8939589_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971987.1|8930385_8931813_+|DUF4301-family-protein	unknown	unknown	gnl|CDD|372920
NZ_AP019860.1|WP_151971977.1|8925034_8925703_-|DUF445-family-protein	unknown	unknown	gnl|CDD|377281
NZ_AP019860.1|WP_151971970.1|8920572_8922495_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971983.1|8927610_8929653_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|223733
NZ_AP019860.1|WP_151971966.1|8918545_8918848_-|NAD(P)-transhydrogenase-subunit-alpha	unknown	unknown	gnl|CDD|378941
NZ_AP019860.1|WP_151971993.1|8934262_8935516_-|beta-ketoacyl-ACP-synthase-II	unknown	unknown	gnl|CDD|274452
NZ_AP019860.1|WP_173013683.1|8924341_8924911_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|378935
NZ_AP019860.1|WP_151971979.1|8925944_8926487_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971989.1|8931846_8932659_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971973.1|8923069_8924338_-|adenylosuccinate-synthase	unknown	unknown	gnl|CDD|234904
NZ_AP019860.1|WP_151971995.1|8935524_8935767_-|acyl-carrier-protein	unknown	unknown	gnl|CDD|179197
NZ_AP019860.1|WP_151971991.1|8932716_8934072_-|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151971985.1|8929834_8930377_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151971968.1|8918855_8919995_-|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	unknown	unknown	gnl|CDD|240629
NZ_AP019860.1|WP_151971962.1|8915894_8917034_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|224029
NZ_AP019860.1|WP_151971999.1|8936311_8938957_-|alanine--tRNA-ligase	unknown	unknown	gnl|CDD|234701

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151971997.1|8935805_8935994_-|50S-ribosomal-protein-L32	gnl|CDD|237038	PRK12286, rpmF, 50S ribosomal protein L32; Reviewed.	1.1621e-22
NZ_AP019860.1|WP_151971964.1|8917109_8918549_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta	gnl|CDD|376743	pfam02233, PNTB, NAD(P) transhydrogenase beta subunit. This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with pfam01262. Pyridine nucleotide transhydrogenase catalyzes the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli.	0
NZ_AP019860.1|WP_151971972.1|8922550_8922859_-|50S-ribosomal-protein-L28	gnl|CDD|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	1.50315e-16
NZ_AP019860.1|WP_151971987.1|8930385_8931813_+|DUF4301-family-protein	gnl|CDD|372920	pfam14134, DUF4301, Domain of unknown function (DUF4301). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 505 and 516 amino acids in length.	0
NZ_AP019860.1|WP_151971977.1|8925034_8925703_-|DUF445-family-protein	gnl|CDD|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	1.67434e-08
NZ_AP019860.1|WP_151971970.1|8920572_8922495_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.25705e-113
NZ_AP019860.1|WP_151971983.1|8927610_8929653_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|223733	COG0661, AarF, Predicted unusual protein kinase [General function prediction only].	9.57836e-92
NZ_AP019860.1|WP_151971966.1|8918545_8918848_-|NAD(P)-transhydrogenase-subunit-alpha	gnl|CDD|378941	pfam12769, PNTB_4TM, 4TM region of pyridine nucleotide transhydrogenase, mitoch. PNTB_4TM is the region upstream of family PNTB, pfam02233, that carries four of this transporters transmembrane regions. PNTB is the beta-subunit of pyridine nucleotide transhydrogenase. This family forms part of the Proton-translocating Transhydrogenase (PTH) Family.	2.30851e-37
NZ_AP019860.1|WP_151971993.1|8934262_8935516_-|beta-ketoacyl-ACP-synthase-II	gnl|CDD|274452	TIGR03150, fabF, beta-ketoacyl-acyl-carrier-protein synthase II. 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein. Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common. This model is based primarily on genes which are found in apparent operons with other essential genes of fatty acid biosynthesis (GenProp0681). The large gap between the trusted cutoff and the noise cutoff contains many genes which are not found adjacent to genes of the fatty acid pathway in genomes that often also contain a better hit to this model. These genes may be involved in other processes such as polyketide biosyntheses. Some genomes contain more than one above-trusted hit to this model which may result from recent paralogous expansions. Second hits to this model which are not next to other fatty acid biosynthesis genes may be involved in other processes. FabB sequences should fall well below the noise cutoff of this model. [Fatty acid and phospholipid metabolism, Biosynthesis].	0
NZ_AP019860.1|WP_173013683.1|8924341_8924911_-|helix-turn-helix-domain-containing-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	8.94911e-11
NZ_AP019860.1|WP_151971973.1|8923069_8924338_-|adenylosuccinate-synthase	gnl|CDD|234904	PRK01117, PRK01117, adenylosuccinate synthetase; Provisional.	0
NZ_AP019860.1|WP_151971995.1|8935524_8935767_-|acyl-carrier-protein	gnl|CDD|179197	PRK00982, acpP, acyl carrier protein; Provisional.	3.35469e-13
NZ_AP019860.1|WP_151971991.1|8932716_8934072_-|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	1.8331e-107
NZ_AP019860.1|WP_151971968.1|8918855_8919995_-|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha	gnl|CDD|240629	cd05304, Rubrum_tdh, Rubrum transdehydrogenase NAD-binding and catalytic domains. Transhydrogenases found in bacterial and inner mitochondrial membranes link NAD(P)(H)-dependent redox reactions to proton translocation. The energy of the proton electrochemical gradient (delta-p), generated by the respiratory electron transport chain, is consumed by transhydrogenase in NAD(P)+ reduction. Transhydrogenase is likely involved in the regulation of the citric acid cycle. Rubrum transhydrogenase has 3 components, dI, dII, and dIII. dII spans the membrane while dI and dIII protrude on the cytoplasmic/matrix side. DI contains 2 domains in Rossmann-like folds, linked by a long alpha helix, and contains a NAD binding site. Two dI polypeptides (represented in this sub-family) spontaneously form a heterotrimer with dIII in the absence of dII. In the heterotrimer, both dI chains may bind NAD, but only one is well-ordered. dIII also binds a well-ordered NADP, but in a different orientation than a classical Rossmann domain.	0
NZ_AP019860.1|WP_151971962.1|8915894_8917034_-|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	2.6356e-173
NZ_AP019860.1|WP_151971999.1|8936311_8938957_-|alanine--tRNA-ligase	gnl|CDD|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0

Protein sequences

>NZ_AP019860.1|WP_151971979.1|8925944_8926487_+|hypothetical-protein
MKKLFISIVSGTIILFIWNAISWMVLPFHSNSLQNLPQGAIDPQVLQNIPQPGVFHSPGLPAEETPEAWQQLIKESKRGPVVSLMVVLPKGVDPLSPQKFLSSLLLNLLMVIMAIILIRLAQIESYTRRVAFFVVLSLLIATLYVAQMIWFGFPLYYTFANVIDPVVSWTLIGLVLGKTL
>NZ_AP019860.1|WP_151971977.1|8925034_8925703_-|DUF445-family-protein
MKKSLFTNLIAIVVFIITYFSPQFTGQQHLYQASLFALSGAFTNWLAVYMLFEKIPFLYGSGIIPNRFEEFKSGIRNLIMDNFFTQENFEKYVKEAMTEETDLSSVVDGLFDKLLQTVEESSFGSMLGMFGGVGALEPLRESFKEKTLNFLNESNILEKFTTGNFESLREKVEQLVDKRLEELTPQKVKEIIQSMIREHLGWLVVWGGVFGALLGLFTSLCL
>NZ_AP019860.1|WP_173013683.1|8924341_8924911_-|helix-turn-helix-domain-containing-protein
MDKKKSLTTGEVAKLCDVSIPTIHKWIREDRIKHFKMPGSGKIRIPRDAVYQFMKSHGFPTDEEQDVINVLLICAPENYNKKFANAILKSDTFQFSIANDVFAAGMTATQELPNIIFVDLSLTGVDNKNFCGSIRNTVNNANLIIVAISSAFSNSQKKKLTQYGFNEFLEFPLKATMFKKKINSLLKKN
>NZ_AP019860.1|WP_151971973.1|8923069_8924338_-|adenylosuccinate-synthase
MKNTVVLGTQWGDEGKGKLVDLLSENYDAVVRFQGGNNAGHTIVIGENTYKLRLIPSGIFHQKTCILGNGVVIDPQVLLEELEVLQKADIGIDNLRISERAQVIMPYHKIWEAIEEKNRGKNKIGTTLKGIGPTYSDKISRSGVRICDICDKDLLRKRLEIVFPLKEKVIVALGEKCPTIDEICDEYAKYGDLIRNYVTDTSLLLEEHISAKKPILFEGAQGIFLDIDHGIYPFVTSSNTCAGAASLGSGVPPSCLHNIVGVVKAYTTRVGSGPFPTELEDEIGERLGKIGNEFGTVTGRKRRCGWLDTVLLKNTHRVNGLTSIALTKLDVLSGIDELKICTQYKYQDQILHHFPNSLNVIDDLEPVYECLPGWTEDIANCKNFADLPVNCKNYIEKIEQLVGVSVDIISVGPERSQTIFKE
>NZ_AP019860.1|WP_151971972.1|8922550_8922859_-|50S-ribosomal-protein-L28
MSRVCEVTKKRTQFGRSIARRGKPKCEGGIGLKTTGISKRTFKPNLQKRKIWVPELNAHVQVKLCKKALKTIDRDGPYRVLLKAGLIKPVKPKKKKKNKDKE
>NZ_AP019860.1|WP_151971970.1|8920572_8922495_+|protein-kinase
MDKKAKINLGKRIQQSEKEDSSSQKNSSIEEFREQKKLQKQQQEELLAVSSEIERLNEELLSKTNRFQSVSAQTQSTQNTQSTQDTQSTQDTQSAQNTQSTQNTQSTQNTQNIQSTQGTQGTHSSQDAERTQRILGTQRTQDTGNTKVRKKDEIGRDLHTKNYYKTSNLPFYKPIQKTQRKRMSDLNLNIPTKRTNIPNFQKKAETPSKTQTLTDKENRQQKTESPLKTQTLTGKESFQQLALQFQKNQKSPIKLNHQNKNDDIEFIQKKEQSQQPQPPQNNSVAETINADFSQESIHDDHLRNFVTSDATINEDVPVSVPGSGYAETIKQTADTQTGPPPVQQGYAETIVAQEPQNVPQKPIDKRKDPMGLIGSFIIDKYNVQRLLGRGGMGVVYLAEHKNLGKKRAIKILPKSATIPEEDIERFYAEANIAASIEHPNVVQVHDIDETEKFYFIVMEYIEGHSLDQYMQKNGLFNVKEAAKIIKLCALGLAAIHEKGLIHRDVKPANFMLGKETVKIMDFGIAKDLNRDVALTSTSTIIGTPQFMAPEMIKKKTIDVRSDIYSLGATFYFLITGQFCFTGTPMQIMYQVINELPVPPEEHNDKISPEVSQIILKMLAKNPQDRFSDMHELVATLDILV
>NZ_AP019860.1|WP_151971968.1|8918855_8919995_-|Re/Si-specific-NAD(P)(+)-transhydrogenase-subunit-alpha
MQISIPKETHANEKRVPVIPETAGKLVKMGAKVIIESGMGLGSGYQDEDYTKVGAEVETDREKLLKEGDIVLRLRKPEKSEIKKLKKGCIHVSYLDPFNELELVEEFSKEGVNAICMELIPRSTKAQKMDALSSQANLAGYTAVIIAADHLDKIFPMMMTPSGTIKPSRVFIIGAGVAGLQAIATAKRLGARVDAFDTRPVVEEQVKSLGGKFLKIDLGDTGQTKDGYAKALTEEQLAIQREAMAKHCSLCDVVITTAQVFGRKAPVIVTADMVKRMKPGSVLVDLAVETGGNVEGSKVDEVVDVDGVRIIGLGNLPGRVAINASQMYSQNLFNLIDEFWDKENKTFKLDLESEIMQGCLLTHDNEVRHEKIKSLLEEK
>NZ_AP019860.1|WP_151971966.1|8918545_8918848_-|NAD(P)-transhydrogenase-subunit-alpha
MDNQVIYLLFILALSIFLGFEIISKVPSTLHTPLMSGSNAISGITLVGAIIAAGTSGGDQTTLILATLAVTFATINVVGGYMVTDRMLGMFKKKGSGGNK
>NZ_AP019860.1|WP_151971964.1|8917109_8918549_-|NAD(P)(+)-transhydrogenase-(Re/Si-specific)-subunit-beta
MNAGLIELSYIVAAILFIFGLKMMSSPATARKGNFVSFVGMLIAIVATFLYLPQLAEAKLGTVTDLHYDWIAYGMIAGTIIGLLAARLIAMTSMPEMVALLNGFGGISSLLVGWAVYQYDVVATIAIKNSTSADTLTLATIFLSVLIGGVTFSGSLIAWAKLKEVIGGKPTVFPGQHILNILLVAGAVTCAVMITKDPTADIANYLFWGAIGISVVLGVFAVIPIGGADMPVVISLMNSYSGLAACAAGFVVKNNILIVSGALVGASGVILTVIMCKAMNRSLSNVLFSGFGGASSSGGKAVEGEAKAASPEDAYYVLESASSVVFVPGYGLAVAQAQHVARELGELLEENGAEVSYAIHPVAGRMPGHMNVLLAEANVSYDQLIEMDDINPNIENIDVAIVVGANDVVNPAARDDETSPIYGMPIINVDKARTVYVLKRGMGMGFAGIQNPLFFKENTRMIFGDAKGTIQSLVDEFKN
>NZ_AP019860.1|WP_151971962.1|8915894_8917034_-|aminotransferase-class-V-fold-PLP-dependent-enzyme
MIYLDNNASSPLAPQVKQFLLEHLDIYANPSSFHTLGKNSRQLLDVAREQVAYLLGGSPREIIFTSGGTESNNLAILGSLPCAPKGQNHIITTKVEHPSVLNTMRYCEKQGWDITYLPVCKSGLPDLDYLTNSISSRTFLVSVMYANNETGVILPIDEITRILEKYNVIFHVDATQMIGRQPLSVSDHSIDLLTISAHKFHSLKGAGALYVKDGTRISSTVQGGKQERNLRSGTENFHNIIAMGQASYLAKTSFLDKMDKIEQMRNHLQNFILHNIPQCVVNGIRAPRIANTLNVSFRGVLGDVLVRELSQHNVYVSHGAACSSGAREPSHVLKAMNLEWDFITSAIRFSFSIYNTQQQIEDLKELLPKVVDKLRNMPE
>NZ_AP019860.1|WP_151971983.1|8927610_8929653_-|class-I-SAM-dependent-methyltransferase
MGIVKSTLKFLWYGSIGASSFYFRRSKFPQILSNSLVHLGPVYVKMGQVISTRRDVIPEEYTEKLSTLCDNVPPEKEKIMRKIIRENLPKDAEEIFSEFGEEPIAAGSVAQVYKAKLHSGEDVAVKVLRPNILSEVHDNFKFIRMMVNVFELLFKNLRMINLPGIVNELEGLLITQTDLTHETDNFIRFRELFADEPNLTVPKVYAEFSSTQVMVTEFVDAVQPYEYEKLNTPGEELASRVDNLMDSMIFLQGLCHADLHPGNFFWNTKGELVLIDFGLVHEFPVEDRNHLTTYYFSLVEGFYHFATQYFIDHFIIPHPKRRKKEFDKKALLDELYDIVKEHSSSQDGFSVVFYKLMHVLSRYQLQLKPNTSKMFLTLITVEGYILHLNPKFDMIENTRKKKMDMAEYTSLPEEVEKMLMQDFGSYSTALFKDNCSIEQAYKNRNEFTMQQIGLKKGQFVIDVGCGRGQMLDAMKKRGADVLGVTISKTEQQLCVERGLDCVWSSWEDFDNVVEKPYPLADAIVIIEILVHMASIFENRAGLMDLRLQKLFEWCSGKLKDHGKLYIQVLNADSRFIEGLKHQETCNEIIEKAPILGFASVKQLVANSDPYFEVVEIHNHSEDLLKTYYYFQQQFDKHEKRFAELLDPKFHRLMRMELNILTELAEKKIMRLHRILLQKKA
>NZ_AP019860.1|WP_151971985.1|8929834_8930377_+|hypothetical-protein
MEKAFKKHRVSSLIYLFILTIFLNIVAVTYFYEQSYEFRQFTNDNITFLTPILNSVISRYSYFYAIDMQYVIFLLWGIIFLSSVIGFIETPQNPLLPNPLNMFFTIAICTIATIAVTVIYYWPYDTIRVGGLFQFYRGNAENFSNNVIYVVNILTIIYLYVFIINRVYLWVQQKDKIQKK
>NZ_AP019860.1|WP_151971987.1|8930385_8931813_+|DUF4301-family-protein
MLNSVDIQFLKQHNIDIDTAREQLERIKQSQRYLTLERACTHGDGITQINDSDLYIKLWQEACDKQNITKFVPASGAATRMFKELLAYIESPQNNSPQIQKFFQNLDKFAFYDQIPSHKHQKQIEVLQFLLTEEGLNYANLPKALLLFHKYPQPRLAFEEHLAEAVNYIKKDGHCRLHFTITEEHLPLFQNLIDSKMNTWEQRWNSHFDIRFSHQEHCTDSLSLNQQGELWRTENGKPLLRPAGHGALIHNLNNCDSDIIVLKNVDNVCPDSRKNDTYLWKKVLIGLLYDLQQQSFRFLEKLHANPDEQTIREAHNFAKNSLHIAHSQELSPTELIDFLNRPLRVCGVVPNTGEPGGGPFWVKEPHGCSCQIVEKVQILPEQQDIMQNASHFNPVDVVCGVKNFRGEKFDLHKYVNHDAFITVEKSHRGKYLKSIERPGLWNGSMHYWNTIFVEVPITTFTPVKTIFDLLREEHL
>NZ_AP019860.1|WP_151971989.1|8931846_8932659_+|hypothetical-protein
MYYLDWINRISRNVIYLLLVLLLGCSGHDKKNIRLQKKPVVRIVNEAQLPQELYRDLREQILYWTPKVYTYNNANPGPVICILTNRQGVGTCYRGTIRVPAFFRPQSIVETYIHELGHHATGSKSLFFFKEGIATATLEVVLEEENRIPDTWPQYGQTNDNWVRLFIKKNEILPLDEIINWAGYMGGSRMGDYRSWQVYVVGGSFVKWYINTYGYALFRKSFHNKKFHKSHQELEKEWKSFLKEEKLVAFYPGDYLPNSRRYDYFIKRLR
>NZ_AP019860.1|WP_151971991.1|8932716_8934072_-|protein-kinase
MNLELRITKGQRTGYLKQITKPERVLIGRDASCDLSIPDDPLLSRQHCLIEITTSGIKAIDLKSRNGTFVSGQRIGEKILNLHDEIRVGSHVFQIVPQQNLSPGVVGKCGQCGCNILDSDVKQRRAFRHGDQIYCQQCLERGIPAKNQRRAPQVTITSDEMPQRTLERPPHPQVKPLPPGIPTQIGPFQVLDILGEGGMGFVFKARHTYLENVVAIKVIKEEFTSEEKIVKRFLQEAKLGISLDHPNILRIHDAGEANGNFYISMECFDGEDVNKIIKKHGPLVPPILIKLAIQMASGLGHAHLKGIIHRDVKPSNILVDRKGVVKIADFGLAKVREKAGQLTASGQMLGTIQYISPEQLEDAKSVSAQTDIFSLGGTLYYTLTGFPPFGEDPPGKVIENILRNDPPPLRNTVANIPPELEKIIMKALAKKSKDRFKTMEEMRDALLAIKI
>NZ_AP019860.1|WP_151971993.1|8934262_8935516_-|beta-ketoacyl-ACP-synthase-II
MTKKRRVVITGLGSVNSLGHNVAQLWKNLLDNKSGIDTISKFDCAEHRCKIAGEVKDFDPTSVIQPRDVRRLDLFTQYALYATHEAIEDSKLDFAKENPLRVSVNLGSGMGGMTLVEKQVQLAREKGFRRVAPYTIPSAMLSAASSEVSIKYGFKGMNFTASAACASAPYAIGLSARMIQYGDADIVVSGGTEAIITPTTMAGFSSSRALSKRNDEPKKASRPFDKTRDGFVMGEGAGIVILEELEHAKQRNAKIYAEVVGVGWGADAYHITAPDQEGKGAEYAMNQAIDDAQIQKEQISYINAHGTSTKQNDVIETMAIKKVFGDYAYKIPVSSTKSMIGHLIGAAGGIECIVCALSVFHNKIHGTANYEFPDPDCDLDYVPNESRDLDVQYAMSNSFAFGGSNVSLVLGKLQNEN
>NZ_AP019860.1|WP_151971995.1|8935524_8935767_-|acyl-carrier-protein
MTRDEIQKKIINIVADIASFPEDKIEGSSSLIEDIHADSLMVFEIAQEIEATFEIEIDEEDLETIKTINDATDHIEKRLK
>NZ_AP019860.1|WP_151971997.1|8935805_8935994_-|50S-ribosomal-protein-L32
MAVPKRRQSKARSRKRRSHDALIAPTYTLCTNCGALTRPHSVCTSCGTYKGVQILKVKEKKK
>NZ_AP019860.1|WP_151971999.1|8936311_8938957_-|alanine--tRNA-ligase
MKTSMEIRNQFLDFFASKDHKIVDSAPIVNHGDPTLFFCNAGMNQFKDIFLGTRQTSDKRVANTQKCLRVSGKHNDLDVVGRDTYHHTFFEMLGNWSFGDYFKKDAISWAWEFLTKVLEIPQERLWVTVFGGDEQDGVPADEEASTLWHEVAGVPKERILPFGKGDNFWEMGKSGPCGPCSEIHIDRGETIGDLALATDPKLGVNGENDRFIEIWNLVFIEYNRNEDGGLESLPAKHVDTGMGFERLVAYLQDKKSNYDTDLLAPIIQETENLCSMKYSAQDTLLSDVAFRVIADHIRAITIAFADGGLPGNKGSGFVLRRILRRAALFAKEYLNTSDAFLHKLVPCVGKIYADIFPEILQQQDHIMLVIKSEEESFSKVLENGTSLFNKLLEETKSKNLKEISGTKAYSLYETHGFPVDLIELMAEQNEVTINHKEWKKAEEKHRELSKDKEFDYNFSMTEIEGLPATKFNGYGKLSGQAKLLKLIGTDKIILDRTTFYAESGGQVSDTGTITGKNFAFQVDDTQKHGEIYVHYGQLVEGNLSQLPRWVSTHVDKQRRRKIMANHTATHLLHSALHRVLGEHAVQRGSEVSPERLRFDVSHPQKITQEQVLSIERIVNEAIAQNTRVSRRICSLDEAKSKGAMALFGEKYGEKVRVVSISNYSMELCGGTHVHYTGNIGCFKITSEGAVQAGVRRIEAVTRGIAIENIQEKNILLDKVQTQLKVGEEQVLEKISQMQDEIKELRKTQKQFEQQQVKIQRDALLQQASDINGVKFVFATLPEAKVENLRDMADLMRKSSTPCAGVISCEKNGKLPLVVFVSDHLADHPKLHAGELLKKVCDLLGGGGNAKRKDFAQGQAIKINQINEAQDLARDYITAATE
>NZ_AP019860.1|WP_151972001.1|8939166_8939589_+|hypothetical-protein
MILQQVVPMVIQYAPYALMFIEETNERTIAQNDLEKFYRDLHNNIQKSDDNLNELSFNLRESLARKNIKIQSIYVVNIKDVSEKQLTHFFTKLSTQGKIHYQFVKANTAEYKNKIAELRLQNNVTVHTTQIAATNLIKEY

Crispr_ID: NZ_AP019860_47

• CRISPR_ID: NZ_AP019860_47
• CRISPR_location: 9189691-9189801
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_47

Consensus_repeat	Method
CGTTTTTTTATTGGCCGTATTGCGATT	CRISPRCasFinder

spacers of NZ_AP019860_47

>47.1|9189718|57|NZ_AP019860|CRISPRCasFinder
GGTAGATGAGCTTGGCGTTTTTTTATTGGCCGTATTGCGATTGGTAGATGAGCTTAC

CRISPR arrays and Neighbor proteins around NZ_AP019860_47

CRISPR arrays

The CRISPR arrays of NZ_AP019860_47

>merge|NZ_AP019860|47|9189691-9189801|CRISPRCasFinder
CTTTTTTTTGTTTGCTGTATTGCGATTGGTAGATGAGCTTGGCGTTTTTTTATTGGCCGTATTGCGATTGGTAGATGAGCTTACTGTTTTTTTATTGGTAGCGTTGCGATT

>NZ_AP019860|47|39|9189691-9189801|CRISPRCasFinder
CTTTTTTTTGTTTGCTGTATTGCGATT	GGTAGATGAGCTTGGCGTTTTTTTATTGGCCGTATTGCGATTGGTAGATGAGCTTAC
TGTTTTTTTATTGGTAGCGTTGCGATT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151972312.1|9174997_9175957_-|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB	unknown	unknown	gnl|CDD|273084
NZ_AP019860.1|WP_151972318.1|9178940_9181346_+|penicillin-acylase-family-protein	unknown	unknown	gnl|CDD|376618
NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator	unknown	unknown	gnl|CDD|223855
NZ_AP019860.1|WP_151972322.1|9181970_9182978_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972308.1|9172488_9173985_+|DeoR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197714
NZ_AP019860.1|WP_151972338.1|9210072_9213483_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972310.1|9174380_9174740_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972316.1|9176662_9178564_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151972340.1|9214099_9215020_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein	unknown	unknown	gnl|CDD|369501
NZ_AP019860.1|WP_151972341.1|9215085_9216171_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|341259
NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein	unknown	unknown	gnl|CDD|380081
NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_151972337.1|9206824_9209974_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NZ_AP019860.1|WP_151972320.1|9181345_9181690_+|hypothetical-protein	unknown	unknown	gnl|CDD|130262
NZ_AP019860.1|WP_151972306.1|9169557_9171852_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151972314.1|9175950_9176646_-|carboxy-S-adenosyl-L-methionine-synthase-CmoA	unknown	unknown	gnl|CDD|273244
NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein	unknown	unknown	gnl|CDD|370517

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151972312.1|9174997_9175957_-|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB	gnl|CDD|273084	TIGR00452, methyltransferase_putative, tRNA (mo5U34)-methyltransferase. This model describes CmoB, the enzyme tRNA (mo5U34)-methyltransferase involved in tRNA wobble base modification. [Unknown function, Enzymes of unknown specificity].	0
NZ_AP019860.1|WP_151972318.1|9178940_9181346_+|penicillin-acylase-family-protein	gnl|CDD|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	0
NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator	gnl|CDD|223855	COG0784, CheY, FOG: CheY-like receiver [Signal transduction mechanisms].	3.88583e-18
NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein	gnl|CDD|370517	pfam09471, Peptidase_M64, IgA Peptidase M64. This is a family of highly selective metallo-endopeptidases. The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase.	5.1297e-73
NZ_AP019860.1|WP_151972308.1|9172488_9173985_+|DeoR-family-transcriptional-regulator	gnl|CDD|197714	smart00420, HTH_DEOR, helix_turn_helix, Deoxyribose operon repressor.	7.71272e-05
NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	8.68795e-44
NZ_AP019860.1|WP_151972316.1|9176662_9178564_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.2232e-37
NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein	gnl|CDD|369501	pfam07759, DUF1615, Protein of unknown function (DUF1615). This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family are thought to be lipoproteins. Another member of this family is thought to be involved in photosynthesis.	0.00326073
NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase	gnl|CDD|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein	gnl|CDD|380081	pfam17973, bMG10, Bacterial Alpha-2-macroglobulin MG10 domain. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.	1.23623e-29
NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	4.55464e-17
NZ_AP019860.1|WP_151972320.1|9181345_9181690_+|hypothetical-protein	gnl|CDD|130262	TIGR01194, ATP-binding_protein_SyrD, cyclic peptide transporter. This model describes cyclic peptide transporter in bacteria. Bacteria have elaborate pathways for the production of toxins and secondary metabolites. Many such compounds, including syringomycin and pyoverdine are synthesized on non-ribosomal templates consisting of a multienzyme complex. On several occasions the proteins of the complex and transporter protein are present on the same operon. Often times these compounds cross the biological membrane by specific transporters. Syringomycin is an amphipathic, cylclic lipodepsipeptide when inserted into host causes formation of channels, permeable to variety of cations. On the other hand, pyoverdine is a cyclic octa-peptidyl dihydroxyquinoline, which is efficient in sequestering iron for uptake. [Transport and binding proteins, Amino acids, peptides and amines, Transport and binding proteins, Other].	0.00194733
NZ_AP019860.1|WP_151972306.1|9169557_9171852_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.33658e-66
NZ_AP019860.1|WP_151972314.1|9175950_9176646_-|carboxy-S-adenosyl-L-methionine-synthase-CmoA	gnl|CDD|273244	TIGR00740, tRNA_cmo5U34-methyltransferase, tRNA (cmo5U34)-methyltransferase. This tRNA methyltransferase is involved, together with cmoB, in preparing the uridine-5-oxyacetic acid (cmo5U) at position 34. [Unknown function, Enzymes of unknown specificity].	3.48269e-76

Protein sequences

>NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein
MKLYLSLLFVCFSCIFAQTSDPWAEVSKLEKKQKYKAALKKVDVILDNAQQQKNLTEWRKSLIRKVTLQTALHGYETSVRTLYEEAWPHDGESNSILNMFCAHTLEVYYYAYRWEINNREKVASAKDVDLKKWSKNEIFKRIHKHYYKAYQVRYTLGKLSVKDFKQFIRIGGYPERVRGTMRDFLCYSWAGFIASTQTWTPQQSREKYRIDFEHLLKASDLRERTLDDILLSDVHPILKLVHVLDDVYFWSIDNGRVESALESQLEKIRLLKSFFGEKHHKEKMAKELSFFLEKYSSYPWWAAGMYELAKLQQEQQLGVAAHTTAVKAVEKYPESLGGKKCLTLQKTLEAPAFNIISMGVDHHGEKSLRIQHKNMQKLFFRAYMINFDAFLKRPHRYPGSVYTNDLRQTLDKQRPTHSWSVDLEDLKDFEYHNTYTTAPMKRNGFFAVFASADENFSTSKNAISSTYMLISNMVVLENRKKGGWEAWIVDGKKGTGVAGATVKLYQYNYNVGARLIDTRKTSLSGTAFFRMSGRGSNYFMVAEKDNDVSFDPNTLYFYPSNVSHNRKGSFVYTDRSIYRPLQEIMCKVVTFDGNSLSGKYQAMVDKKVKLSLLDPNWKEVETKTVVTNSYGTASESFTVPQGRLLGLYRLRAVVDGKTSYANVRVEEYKRPTFEVELQKPKEELRLNNEAQITGNARYYFGLPLTTGKVFYRVTRVPVYPYWYWWYYRDLSVQSSDEVASGYTQLDTQGEFKINFTPEANDNLPNKEQISYRFEVYAEITDEGGETRNSSSTYNIGFVAVKAEISLNDKFVSAKETAKINIHLQDLNGVARAGEAQYSLFRVKQPQQAMLPKDLPFEKIPGKKYTPGDLMRPRWEHNRSLQEYLFSFADGEQVKSGSVTHGKNGKANLEFSDLTPGVYRIRYNTKDKFGSAYATQKEFIVADNNARVAVPVFLIPKQNKVSVGGEAVFFLGSGISDQPLSVEVHQNGHMLKRMWIDDASQTRMFKVKVSEKHRGGFSVRIHGVHDYQYYSLTENILVPWDNKELQLNFATFRDVLRPGQKETWTVQVKGPNAEDVAAEVLAYMYDRSLDFFAPHTFTSPATLYPAKYGVEYTRHGLFTRSFYSIVNKGWYTIPAAPSYYRDQFMAFRSYGVGGPGRRQFYRVTTRPEETGPAIHLRSEESLGEEGFADDSSVESGDLGGAVPEGNTVLKQQAVPRAPKVPAQKKKGEEPRVRSNFSETAFFLPHIVTKKGVATIEFEIPDSVTEWKVYVHAITSDLKYMSMNRTTATRKDLMVRPYVPRFFREGDKATLKAVINNATAKQMNGKVTLRILDRNTQKDRSNDFSLQNHEQKWTCAGNGSTNVSWSLTAPSKLGEYAFKVVAVSDNVSDGELRPVPVLPSRIHLSQSRFVTLKNNDMRIMEIKDLRDAEKDASLIHDSLVVNLNGQLIYTVLQALPFLTEYPYECVEQTMNRFVCTGMVTSMYDQYPAMKKMAEEFAAKRDTKYAKWNAPDANRKMALAETPWLVSAEGGSKDNLINVLDPKIANYYRQSSLDKLRKAQLNNGGFPWWTGGPSSAYMTLYLLSSFARALEFKVDIPQDMIKKAWTFMGQHFRDYYEKRMVIENYGYEFITFLNYVLSCYDAKSYQHAFSEKQRWAMLEYSVKHWKDHSPYIKAMLSLTLKRMKRSADAIMVMDSIMDSAITKQDQGTFWAPEDRGWLWYNDTIESHAFILRALMEVQPYNDKHLDGLVLWLLLNKKMNQWKSTRATAEVIYSLVTFMKQQGSLAVQEKAIVHLGGNKNEVVFRPDTYEGGQKQIVVEGKDIQPETMAKVTIEKEGKGYMFASMNWHYSTEKLPDEARGDFLQVTRKYFVRKHQGKEYVLTPLEEVEKVSIGEQLEVHLSIRCKHPMEYVHLRDPRGAGFEPENSVSRHRWEYGIVWYEEIRDSGANFFFERLPQGEYNFTYRVRANMNGDFRVGPATLQSMYAPEFSAFSSGKLISVK
>NZ_AP019860.1|WP_151972322.1|9181970_9182978_+|hypothetical-protein
MVDALKQLDICVDEAKSYPGLTIIPVYSEKQNDFHVPKLFGEALKDGTMKIQEQKNSNVPRLTVDYKGEGYALGIKGHLLIGGGQDRQLYHSCLISQGCYEIPVQCVQHGRWNPGKNKNFTVCSDITSSGLRFNTQNQGQTWEKIRTYESVTHTNSGSESFTCTRTITMGSMEEQSSLMNEQNIKMSKQMIAVRNRAQKMLDDLKNPQPQQIGFFAIQVNPFIWVKEKRIETNYLLEMAGNAMLWKNIHQKAVESIIYDSAICDVDSIVELNDERKAEIAEFIAMVAVEDWEESDFIGQESRFSLMSKQYFGEAIFLDDPEEMPIHLLCSSLKES
>NZ_AP019860.1|WP_151972320.1|9181345_9181690_+|hypothetical-protein
MGNMIGLFVVCGVAQMFFPWWSMAVAAFIFGFVMVEGKNDFVVFAKGFCGVALLWICVAALQFFTTSQIIATRISDLFSLPHPALCIAVCGVVGGVVAGIATFSGCQLRQAMFD
>NZ_AP019860.1|WP_151972318.1|9178940_9181346_+|penicillin-acylase-family-protein
MKWLKFTCSLVVLIFVVITGNSRLPIGNNKALPPLGKFCDPFHGFWANGESKTQTTLSLPALKDEVTVVWDEREIPHIFAKNERDVSIAQGYLTAKYRLWQMDFLARVASGRLCEVVGNRAKKLDEENRRIGLTFAAERTVAALEEKAPQVKKLLDAYCEGVNAYINSLSYEDYPVECKVLDYKPELWSPLKTFLVQKYMAKSLSYRSEDREMNNIIAAYDRKTMENLFPLKNSTSPIIPSGTEWAFTPHGIKDDKNARNTNKIYDIPFPNRPDMIKGSNNWAVSGKKTLSGRPMLSNDPHLKLFMPAIWLEMQLSSPEVNVYGVTIPGLPGIVIGFNENVAWGMTNSVWDVIDWYKIKYKSDKKDFYRFDDKWLPTTKRREVIKIRGEEDYVFDVVYTHHGPVSFDEPVPIALRWTAHDPSLEFKAFYILNRAKNYDDYRKALTYYDSPAQNIVFADVNGDIAITPNGKFPIKPDGFGRMLEDGTTSSTEWKAYVPYEHRPHIKNPESGFVSSANQHPTDDTYPYYYNGRFEYYRNVRINERLAKMQNITIKEFNSLLNDNYNVHASTVLPTLLKMVKGDDADSKSAIEILQKWDYNNDPDKIAPSIFYEWWRSLVPAIWDEFRDGKKYTKPGWHRTVEIIVQDPRSKWFDNVTTEKQETLEELAQNTFSGAVKKLSNAHGTLTSENTKWRWGNHRGCDVNHLMRIGAFSRKDLFVGGGRHIVNATRKNAGPSWRMVVELSSPIKAWGVYPGGQSGNPGSKHYDDFIGKWEQGELYELLFLASPQDRQEKCVRKLVIGAE
>NZ_AP019860.1|WP_151972316.1|9176662_9178564_-|tetratricopeptide-repeat-protein
MSENNSSESNTLQPRVTQVNTIQSPQKAKQEYIRVRKNFHNYYIEYKLQDSGIANLYRAIDQQTTTPVLIREFDATDNEFRDYLSWEYNFLSHINHPNIVKARELIDCGDKIAIVFEFAEGLSLKEILAEERKFSWPDRIAIAYNIANGVNVLNKAGIILRDMKPANIMINQQMNQIKILYHGLENPSNKKNLRITLRNKVDESVMYLSPEQTEGRQSDRSNVFSLGTICYQLFANNKKSPFYSDNPFSCCYMVGSHNPLILEKVINSRDIDKDLRKYISNVIKRAMEKNDKERWVSAEEMAMQLARCYFAVINNDNTLLQKPLGFQPQIDLSGKEVQLQEKEEITSLVLDIDNIDIEIPADDIPINEETPPKKNKKLTNRIQYELPNLQKATQGRKMTLSALVILNVVISCWLILAAPKQNTNEGVTEKPQYTTAKKLFVQKRYLETMRVLQKIMQKEKNNAQLHRDLAACYKIFGEYTKAIHHYEKMLEITPNAEIYYALGNCYAYLLSYNEAISCFKKALKIQPTFTLAAVGMADIFYATRQHTKAIYYYKQALKQATTIDEKAKIHFHIALSFFRQKNYATAVDHYSTAIELKPQEARFYNKRAAAYKQLGKEQLAAKDLATFHSLQIK
>NZ_AP019860.1|WP_151972314.1|9175950_9176646_-|carboxy-S-adenosyl-L-methionine-synthase-CmoA
MTYDNIYSSPRKKIERFRFDKEVVDVFDNMITRSVPGYLTIVQMISMMANNYVQPNTSIYDLGCSLGKVSNAIRQKCATPIIAVDSSEEMVQSAQKNLQGLSDIQVICEDVCKTKIENASVVIMNFTLQFIPREKRQQLLEKIYAGLHPQGIFILSEKIQNSTLQIDLHQSFKKDQGYSQLEIEQKKRALQNFMLLDSKDEHLQRLHSVGFTKNELWFQCFNFVSFFSQKC
>NZ_AP019860.1|WP_151972312.1|9174997_9175957_-|tRNA-5-methoxyuridine(34)/uridine-5-oxyacetic-acid(34)-synthase-CmoB
MLNYQNLYDTLNDDDRLQNWLSHLPQTVNRALDPSQNSNIIKWRSALEKLPDVNITSVDLKDSVTIDGNFTDTEFLRELLSQFHPWRKGPFSLFQTHIDTEWRSDWKWDRIKNAISLKQKTILDVGCGNGYHCWRMAGSGANLVVGIDPLPLYIMQYQIFAKYLPQVPAYVLPLKIEDVPMDLRAFDSVFSMGVLYHRRSPIDHLYHLKSCLKHHGQLILETLVIDGENGQTLLPEKRYAKMRNVWFIPSCLTLEAWLKRCGFIDIELVDVSTTSLHEQRATKWMTFESLRDFLDPQDTSKTIEGYPAPKRAIFIATKK
>NZ_AP019860.1|WP_151972310.1|9174380_9174740_+|hypothetical-protein
MHNRDPQNLQSLEKALDELNTSYRTRRGIVIKPDVSGLASSGHHLLTTDEGLLDLLGTFGNGQDYNDLLPNSHLMQIGEIQVRVQSLQSLIELKKEIGREKDKAVLPILIQTLKEHKND
>NZ_AP019860.1|WP_151972308.1|9172488_9173985_+|DeoR-family-transcriptional-regulator
MQVKLVRNIWQHWGFNGNPFDTNALTLHSKLLPISKAFVGRSMSSNESTQLLNVIRNSGGGRAIVEGHIGVGKTTLVNYHRYLWEQEAEDKLFTPIKEISVYGKTTAKSLLVEILGHISSKMLLLAQEKKIKKSQQLKKIRFLYDIFYRESHDIQGNIFGCGISYNRQTQLNIPDLTESQLIGYLMDIIREIQELGYGGIFLHFDNLELLSSDDLKKCKMLFEEIRDILLLPDIYYIFVARKGFFSQVISPSERVSSIMGWPIQVPPLTYQEVIEAINTRYALLSIEQGKEIKPVENSFIKYLYELHKGKIRFVMDSIARVVLSYPYKKYKTLKKEEAIKFLTKIIKQKTNTLSRQELVILSEMIKQSEFSNKSVTTSLGLQPSNVSMYFKRLLEENFIYLVRKDGTKNIYSIREELTVLKNKIHLKIEDKKYNKKEARKTTMASYIKKHCKITVSCYQDIAKVSEATARRDLQEYVKDGLLQKKGKGRATIYITVDS
>NZ_AP019860.1|WP_151972306.1|9169557_9171852_+|protein-kinase
MDIDKKWKALIGLDNENATATYKGSGSLPEETLATLMGTVGSDKTVKQNIHVPSTNYTLSSKIAQGGMGIVFRGRQTNLQRDIAIKQSISTDKNREGKFIAESVMTAYLNHPNIVPVHDLGRNEDGHVFLAMKLVGGVEWKEIIYTQDTDKKYSLEKHLKILLNVCNAVAFAHSKNIVHNDLKPSNVMIGEFGEVLVMDWGIAVDIAAKPRTNMLHKSHVESPMGTPAYIPYELANGQGEDIGPWTDTYLLGGILYEILMKQPPHRGNPLEAIMSCSLGKAPSYDESIPLELRNICNKALSRDIKERYPNVAEFKHAIENFLQHRESLILTEKADHILDEITTYLEEQKQGRLLLAKLKYIFFDIPGRMLFPFFWYYSNMLGKCIFAIYIALFSFYSFYFEDESLLLSVLVGIPCLFIVSNVVFVLWQFIKAVCFKKEIGVLPSRLNAMNRNYLYANLIKAITLYERSIEIWSGNEHATEKKRYAHAKFADIALQCKDSGLAETHLQVLKGIEDPYVAEIRDRLIRVKVEEKSDRTALAMSKFLMAAIVYICVFFVIVFLIFWEYIMQMSSFSTNENEAIALLQSYATKQQIFRAEVHCDQNNNDRGEYGFLQELAGVTAIRGKQHSLAPRLIAEEKQRFFTNKNYYFYCYLPGENEVMTEDDVQTLKSDSAIITDQERRFVIYAWPKERGKTGHRAFAVNESGFILATKEHSYSGDKIPKANAAYNENSAPTNKLEGTWCVGVGADGNNWKHVVLNKDDDYSD
>NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase
MLNIAHFIHNSNMRSPQKTAMRLGEKSFTYQELTALAGKVASFLEAQGIKKGDTVALSCPNVPYFPIVYYGILQLGAVVVPHNVLLKPAEIEYLLNDCEAKAYFAFEGTPELPMGQMAWEGTQKTLCKTFVIMTADPAAPSPIEGATTLGQILATSQPKQEITPTDANDTAVILYTSGTTGKPKGAELTHFNIFMNAQISRDLVADGAGHEDVFMMVLPLFHSFGQVVGMNATFYRGAELVMLPRFDPQVTLQLMYKHKVNIFAGVPTMYWALLNTASKIPEEQLTAVKNNIKVCASGGAALPVEIHQQFKQVFDVEILEGYGLSETSPVASFHHRGRPLKVGSIGEPVWGVEMKVFNEDCEEVPVGEVGEIVIRGHNIMKGYYRRVHETEHAMRSGWFHSGDMGKMDEDGYFYIVDRVKDMIVRGGFNVYPREIEEVLQQHEAVSLVAVIGVPHEQHGEEVKAFVVLNENAHITVDELIAWGKEKMAAYKYPRLIEICTELPMNATGKILKRELRDREAKKQEDNSQE
>NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein
MLKHTIILFIAMITIICDPYPKEGKVYKNPKDLQDNTTFALAPLMTEQQVFSEAQQVIRVEVEWLSTTDTFRFAYAVIENSGTAALSKRTKNLDTFGSYRGQLVDTNNNAILYYNSLGTGQQYRKLSRSLTFRFPIPQDVVEFQMIAENPQTGIMEHVLTQKIDPQTIPVVKNSMTFNDIEVRVLQQATKLPKLIVNVYAEGYDTSGKNSFWQDAPKVVDRLRSKNFPMFEHLEFRGVFAVSQQKLGSAKKLGFPIPERDSFLGLYYPYWDDFGRWYHVIYPTREKRFRQNIGLVPYDYPIVLVDSSSYWGVGNFKEHTAIPARSSSFTYLLMHEFGHYFGLNEEYDSGGKTELAFAPGIREPWSPNITFLNNKQNVKWKQFTTKGVPIPTPKSYWTGSGPYGAYRGGYAQTPPFGKSYKPGFGCIMNSGSNFCDICRFSITQRIRFDLGLETKPFSFNNTQQCCK
>NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein
MAQKYITKDNYLGIKGDLTLPPVCIITGEEVQGESVHSNIVQRFFSPLHVILISVSTVSLFLVPYALLFYVSLYVFYKLCTRNRYPQTIHYYISRRAIRTSMLWNLCAATSFAVLVAYYERIFPGILAAWLIHYMFARTEIYIVKREASYTFLHGISTRARKKILSLNISMANRPFPATASSETLGNDHNLLPPHVIENLSPPSKGNLQPIVKKQSKKTIDISGQNLKYVHQELLEGVVEKDVEEFKASNNPIGQIPPGIFAFENLRNLEMNNTRITFMTGIDKLSRLEKCYVASNRIRKIPDEIRKLSSLTTLDVSSNRLKDIPAEISFTALIELRLHNNFINKVPEQIIHLRSLTILDLSNNKINELPENIGQLKLLQKLYLQNNHLQSLPHSFAQLHQLEELNLGNNQFSEIPQELQHLPKLCHLNISQNEISDISGNNLQNLMNLDVSHNNLSQVTLCFPQLHTINFSHNNLAHVVIDVETSQKLRQIELSHNKLQQLPQEIFHIPSLEKLYLNHNQLQNIPSLENAQQLKKIELRNNDLHEFPKSFANLQHKVHIDVSQNPHIDIPAQHQHEIEYDWSKLNVFDNKQPLNPFIVKTKEHVIELTTTECIPYPDIEKYQQQTYLWQSGHLKPLTKIENTIPENTAIISENKLHFVREKRRFAIKETFAHYSLLLPCPNNDSLSKVFVAYDNRNFCRIEIFEASLSFHKDFITSLQQEIKKQRGQEATTVYTLGQHQQQIYVVTNFYKGVPLQHYIQNNQLSLGETIYWIVQVLSLVKRATIDNNYITLNNINAYHYTLNLVGLETQKARESVQKNISHQGKVQDNKYHFCSPQVLMDKSTPNTQPNLIYSQGIIFFFLLTKRLPFHHTQLLQLILLIIDKQPGDMTIYNHSLKAQPICDIIYKMIAKKPQDRHQNEQQVIADIQKHYPKLFIKHFCIHKQVNSGKYYKMYTGLDTKTAQVSSIITFHDTIQLSSIQKKCIHAYPQIQFFNDNGHNGVAIPHRHLHRITEKQQPLTVVYFALEIIDILQELNAYDLFPILHENMLGIDEKQNLRLNIPEMMQQLATKKEDSTQLVSIEKACNLNNSKEINYRLPDEILTPQYNTTAQIYSLGVTMYNMVSGSYPYTKKELLHMDSSFYHRRILLHSNETPQPLRKIINKAISYLDPTYTKWQQLRQDLHQCYNELKTKLLNSA
>NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein
MIRGEELEKAWAEFQDSPQNEEQFAVLKESFLGVGDWKKLVELYSLHVGFVEKRDPELGAKLYGERASIEEKYLSRSENAFASYQKSYALQKQNNPYMSSFILLCKSMKNWEVLCNIWEEQLQNSKSDNEKISLLQQLATCHLQEIKNREKAKEIFRRIVDEFPHNEEAFEKLELLYLEDDDYEKLIAMYRQQIQSSSENDIKLKRLQQVASMCEQLQKTDEAIKFYMEILSLQPQQEYALNALESIYTEKQDWQAVLGIMRKKSQSLSEPQLYDYLISMADIAENKLGDNELCVSFLEGAVAKEDFAILTRLEKHYSTLQNWQKLAGVYQKQIELASERKKKREVYFALAKLHEEHNSKSDAIACLYKALEDFPKDKEILERLKSMQSDDEDGLLDIYRLEVNWLQDPAKKVDLWGKMGQILQGKERWNEAIAVYEDILKLDDENLHAYEELQKICAEEDQKEKLLQILVKKSKLVRGEERVEVFNEIAELCTLLRKEDEAIVYYQKIKQLQPNNRKVLYLLADYYREKQEHKQLVAILQQIVNVDKSMYEHGYMEMAEIYENHLNNIDIACKSYEKIIQAVPDNLEAYRRLRSLYKRNNKKAEYLQITSKLASITPKFKEKLDLLFSLCDFYKERDLVSKLEEQLKNVLEVDSHNSRAVESLKALYEKKQDWKKLIAVLQKQSQMCSEIEDVIDIYYKIATFYQEKLRDADQAVLYFEKIKALKPDYVDVLRKLEVLYTQLEAFEKLVKILQQNSYLSVEVSQRVNYIFMAGMILEEKLKEPQRAMWAYENVILNDPYHINALVRLKKLYKGAGDVDKLEAIYEKLSVVTTDNNKLIELYLDAAQICDNKALYYQKIVELDAKNKEALEQLASFYQSDENWEKLIDIRKKQLEICSEKPKIIEYHTHLAHIYKEHVDSPSQAAVHYERILHSDNKNKQAIENLLQIHSENWEKLLGILQLKMRICPEERREILLKIANIYHRKTMQLNEAIKVYNDVLAIDENDRRILEILRNLYGDIEEYPKALQIVNRELKLDISHELKVELLLKKANLAQHHINQPTMAASTLEELLQVDPMHEEAFYRLESLYHKREEYDKLLKVLHNRCEVDEKRRLSLKLNQAYICEKTEKWDEAITTYKEILQLNDKHEEAKKALVSILRTQKKWELLIEFFEEELQKNTDYKAMTDLYNNLGNIWSEQLNKCDEALEMYQQVLELDSSNLLAIRGLQAIYARQKNTEALLKMYIQELEVESIERERRIWLYLMCGDTYEFVLHDWDQAHESYIKVLYNELDPNNLIALRGLQRVYRAQKKYSELQVMLLREFQLQTEDARALQLHLEIAKLKERYLKDPEGSIEYYRVVHEAWPNDIFIINSLETLLHGQKMWNEYVAILEKKIELTKRYKNVLEVHESAMKTYGNYLREWQKAVDHGLAILEIDEGYLPTIQYLQKMYKKMEEEESFAAMCVKEANLIYEIGDRKRICGLYLEAGKIYALLDKKEDAIFCFERILNVNPSHSKALMNLIQIYSATGNWERLINVYEWTAQVSEHEEEVVNLHLKIAYTWEDKLQDNLKALPHYQYAYSKNSQNLAVVKGLRTLYEKMKRWPEAAAMLLEESELEAEEKKAKIFFRLGEIWEKKLNSPIQARDNYLKVIGYGFHRKTSETLVEIQEKLNDYEGMTKILEEDARKCEPQERLNKYLQLGKIYWYKLHKADEAIRTYSKVLKVDSQHPETLKVMAEISKYRKDWKMYIGILNRQTRNTQDPEELYNLCVQLGEVFHEHLGEGNRAIDFYEQALVYKEDLQTIRKLQYVYEEWGCYKKLVDSILSIIDRANGHEKIALYHKLGHIYGERIFDDNSAIGAYENILDIEDDIDACYALAKIYKRQYIWDKLIGIYDKLIADAKLRMDTEEQLKVQLDAAQTYYYYLEDYDKAYNLFKSCLELSPSNDKAFDLLEEILEKRQQYKELANLLTNKMNITEDEQQKITVLHRLANVYIDKLQQPENAVHYYEKILQISETEILALEKLEGLYSQEQNIEALMNVYNLKLKAVEDPAVVSDTYYKLACVYLENYQDTEQATAHLRMSLNEDPGHIDSIKLLADILVEEQNWEQAIDYIQAALGTTKNPQEKYSLLTKVASIYKSSINDLSKAKGYYLQALDIQPKSIEPLSEVIAIYSADEKWKEAEILLERLISVLPEEETDKIVEAYYDWGVAAQKQKKIDQAIGYFKSAVEKNNEHLPSVLSLAKIYFSKQSFHESLTYYEKAYSLESEETNINIIHQSAILHKILGNIDKAIEFYQMLLDRKFSRLETLKSLSSLYSLKKEWDRALLYQQQVVNESPEGEESVAYEEMGDIYKELDNLDKSIDYYLKAIENGKSDIKLKKKLVALYIRQKDWEAARNYNDLCFSELQEAEDKEENRNLHARILIGLGQKREAVHCYQETLKVNPICIKAIKGIAEIYLAEENWSALSNSYREFLTNLPEDKKENGLPIHLALGFLYLEKIQKDDLAIEQFEAVLQLDHDHTEALIALTKIKTKEPASQEEAIKGHFRILKKDSLRVDSYLSLHDLLEKTDKKNRAMKCYRAYQYLSNEKVEVSSKLVPVNNDLISSFIIPKPIQEVREVISTIEDYCEKIYQTNIEEKFDIKKREHLGAERVQRPIWYHTHSIMKAMGIRDLNMYITAKHRNKIFLENTNPPSLIICKNLVDNLSEQYLRFLIAKYLFYVSLKQILVQKLEMHELHEHWKMIYSCFGKNMFDSAEFGVDQKKLRNLIPRKTRKSLEAKEDFWQKFINCDIEQYVRFMDYASNRCAFTVIDSLETSINTIYFWEMGVHVKNKLEELRDMATVHDLLLYNISESYEQVLKQD
>NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator
MHDKKGFTTGEVAELCHVTIPTVIKWIESNELEGFKIPGSKNRRITRENLIKFMKKHNIPIDQLQKNRPKILAVDDEEIILEVFQGIFDEDSYDIRCVSRGFDAGLAKEFKPDVIILDICLPDIDGNTVCEYVRNMPEMKNVRILGISGNITKKELNDLKKRNFDDILAKPFDNDLLFAKVEKLLRK
>NZ_AP019860.1|WP_151972337.1|9206824_9209974_-|hypothetical-protein
MAKIRLSHQSYEKHDCVEIPKNTKITPDIFEYLKKRTLRAQEKNKKILITLPGNTAVSKRSIKEFLQFFQQNKEYLFIPQEALKWGRIWDNIINDDLATTDMDKALAWLADDSFLTPKIVRRELGNVAYIKFSGHVANASKHAAKKIIQSLEEIKPSGRMLEVANVFDTGICNSWVPISGAIVLDIADLFILNQRFLSAITEALEEYNLSVSSKGIFFVTSGLFQSWQLKKILKGQTINEIGNMIRVISSRDSDNESKIQKELAAITSASQKNDPPKPLFLHTVQGHDSALKTIDYFSPDLVIVDEISEATAIKQNVLKSRGEKINHIIPATDPGLRILSPQMITKGYDYDLFAEYVMSRYLHNRGKPNETYIYYLNTDQDRMRKTSMFLGGELSHVIDEDLEQIIEYLPQCETQPDAQGSFTIALLEKQFLKFEVDLHFTVNGFSQLLSKYPNLFTKHKDSLTTSVRLYLKAAQISHPIQAKLHLAESFNEFSITEENINIEIRVQDTRNMLTFKATPHEGLEKRFKTLFTLLNGSDIFDSLPDKELFIELVSLLWENYQASMYRTQGFTISLISENDGSFRLEVFQSKQNKAILSGKVVDGKRQLRFTGNTLHHPQAQKRLLKMISLYFNSGQNDPTENTWRFACFEAMTQVLANGSQNQSLSFDLQVQEPRWAAIIMCDSIAPNMIAERSKKMFDEGADLVKVGDNGRQVTLVRKPDPKETDAVLGFDSLQSELDGLQENAILEKVENVKSQEAEERSLKLQKTYEEALKAYNQKYGGMDDEDDMQATGRTSRPKTLEESARVKVVRRRVMPKGEIEKRRKKMRMYIASGATVFLIAAVLFVSVSFSGRSTGERKALRVKNIDSMSDAELAEMYAKKKKTKSPSKVDKPQKDNKKRDPDPHAQLVKNTCRALYVADAPKQELLNALLKELFFALRKSPNSADAHNLMARLFWYKVHLDTQKIFPKKWKVSWRREAKLHFEKARELYRKDTIQSGISLRIRTWMPEYYIYESNKPKKDKSKKSVFYAKYDVYKEALSDIDLLNSQLR
>NZ_AP019860.1|WP_151972338.1|9210072_9213483_-|hypothetical-protein
MKKLKNKERKGITLIIVTSIMLVLSTTAVTFVRLTGYERTAASNYASTVDAKLTAYAGVDHALALIYDNIRRTGRIGLSEPPVNGVTLQYPANSDRDVFLASQTPEPISLELDIDLYNDGDNNDPFTVSGLVGRTIGGDIFGTSELHGNFYSLKLEDSSGKLNVNSFIPVNVNANGNVTLRTDAATVVPSAETMRRLLLTLAELAFPASDANFHNALASAVLNTPLNPNTRTRFTSMQEVETKINTDVAGFEGSAGAERFLSNLTTSSIIDTSTVAVSVEDALDLRDAPEYYHEARAPVNINTASRDVLIALIVNIRGRANFFASQIQDDDDPTFSNNAIRVETTLRNDIAQFEIAIPQAEAEALADEIIRRREVDGNPFLDQGEIDEFFNAQNINIPVPNLGDPTNGAINAATVVKNTGLNPGSPVVSQQVWNQAVRDMLRSNFNPNTVENFWNPNAGAFRRVSTSDLVRIESDGTNLQTNPSHTLELVPSSVGSVEITSVGRTTAQQGNLVTGISIIETVAEFGREVTHTTQSDFEPDTGLATTVTSPNNIAHQRAVGAPVDEDLFAGAVEPNPILDINGDNPGNGNRTGGGNSFSSGNNFVAAGNNEQQNRFNTNGTYKSPAQWTTQTVNPGGAKTIKYNVRAANNSLIKSFEGLPFIMEAKNTVRQPGNNITYDGLVSRRMYYTPDFVREVSPSDAAIGLRQNDSLERYLIETCFEDFTTSSGGDNVSSYLANRSVGNSQPDLRSGNTSGESKMGNRNGSVQFWVKFDADNTDDINGNSIACGLFGATTASGFRQGRVANDSQGNDLFGRTDIFFREGTQTYLYINALGELRATRLYYALCFPLTGQTPYGAFFDTEVDFANRKVPRRDVIMRTTPFKAHEWYHLRLVWDDTLNGNASIDLFVNDEKVTPNIATIEEVDELAFNNEYCLLNEREPLDGMFINGFPRAQAKKGGYFHFNEDGDHIHMPGNATIDQFISSESKNFATTSGDSRRRFPETTTYTNSFNLNDDDAVIAAIRWTSYPPYRQDADDDSDFPSVRLSSVTVNGTSQGVNQNNTTTEDSQQRELVVAGDIIGNTNINSQQVDYTFEFTSPRPKQPVNNTNELQGARCATLDSVTLLMLKRYPVLRDTEIQ
>NZ_AP019860.1|WP_151972340.1|9214099_9215020_-|hypothetical-protein
MIKKILCIFFITTFISLHSQEATKFVKVKTLDLKVVPYPWANELSLSINIFAKRIFKDVKFQIRLQYEGRKIGSYTVTVKENEGRYYAKKKFEPLNKPAQEVLYGDYNVYIEMVVEEQNSKFKARWKKFSSATRLAIAQKTFSIGKKNQVQKQQKEIQEFYIERMKELNRLYKILKKQEVVEYRNRGFRRQKWRQWLYTEYLQKINNEKKQLEIRQARVYHPKYNYTLNGMKYYCDLLVRIGKTSTMILYKRHGLKQDATSMSGIDPFAIKSRKSLNKIIEGIHRSSAKEMGISLKKELGFIPPPK
>NZ_AP019860.1|WP_151972341.1|9215085_9216171_-|hypothetical-protein
MKKLLTILLILITCIFADKYKVSVDDISQYKVDYKILNPCAVSNDASYFFATERVYDVKKIARGNAYDLIIFRFKDKKLETIDRIPLKIYHLVNVAYDSDRHRIFIVGNRGNKIIRVDPRNNRKKVEFEYQQGQKGFKAGPFVFCHKSKLYATGWFYDEEQNWLGDYVARIAFTKKGVRFQRKASLDYLFKYRFSNRGTVRTNFYVSGDLFYFSLIDQVEKKTFLMELRNKKLTPVDKEHIISTFAATDERIFYITRDADGHYHHFLKNFTTGEKYTIGRENDRFTYPFLVKDRLVVLKTDLKRKTFNAYVGIEKDRYLLQRFIKNETLGAMKISQNAKYYLFMGIDGITIGTLVRNESTE
>NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein
MTASAWCCGVRSINLVQAQNQVQQQQPQPAPPITQPAPAPVPEPETLAEIIKADLADFDKFGSNDQETNFDDNAVERLSEAAIREVERFEEALNLPTFAGDSDESRIDRNEKQLDIAENLAPQLQQRVLEFISDVNNDVSKFVAPENQAILANAPQSVIDSFYDQVSNLHEEFFVDLNNAIKLELQTGIDPNSVSTNTLPDGSTQQETTDNLAQIDDTNSAVPTAQRILDRLQFTQQEFLNDFKFVRESTLEEIQNIETINNDQSSEINTTPDFDGALDSTFQSPTQTNRIRLDVLNPLSLPGANFDRGTASIVSMIQDLQNRFSGSQLARDLDFFLAVFPSSQETAVQDSLEPRTDLFVNGQTTLNDLQDRELNQNDANQLADFETENTFTTSSFAIGLDGRLVGIDQSDDNPVISQSENVTRIQNGSSFNTRTFGGTPGQFESVRITVGDRTYELYDHVFTSPIVLDMDGDGKLEASNGVYLPHVYKDGRVVEFDINGDGFVDLTEWVGKNDGLLIQYDSSKPVSGAQLFGDADGFINGYEKMRSLDADENGTLEGQELSTLSVWQDKNLNAKVDAGEIQSLADLKITELKVEHDNFVSQFTIDGEERTMWDWYPSVFRVKKRK

Crispr_ID: NZ_AP019860_48

• CRISPR_ID: NZ_AP019860_48
• CRISPR_location: 9205840-9205939
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_48

Consensus_repeat	Method
TTTATTGTAGAATATAATCTATTT	CRISPRCasFinder

spacers of NZ_AP019860_48

>48.1|9205864|52|NZ_AP019860|CRISPRCasFinder
CTGGTGCGAAGCATTGCAAAATACGCCCTTCGACATGAATAAAATGTACTGA

CRISPR arrays and Neighbor proteins around NZ_AP019860_48

CRISPR arrays

The CRISPR arrays of NZ_AP019860_48

>merge|NZ_AP019860|48|9205840-9205939|CRISPRCasFinder
TTTATTGTAGAATATAATCTATTTCTGGTGCGAAGCATTGCAAAATACGCCCTTCGACATGAATAAAATGTACTGATTTATTGTAGAATATAATCTATTT

>NZ_AP019860|48|40|9205840-9205939|CRISPRCasFinder
TTTATTGTAGAATATAATCTATTT	CTGGTGCGAAGCATTGCAAAATACGCCCTTCGACATGAATAAAATGTACTGA
TTTATTGTAGAATATAATCTATTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151972345.1|9218603_9219245_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|227305
NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|341259
NZ_AP019860.1|WP_151972318.1|9178940_9181346_+|penicillin-acylase-family-protein	unknown	unknown	gnl|CDD|376618
NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator	unknown	unknown	gnl|CDD|223855
NZ_AP019860.1|WP_151972322.1|9181970_9182978_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein	unknown	unknown	gnl|CDD|370517
NZ_AP019860.1|WP_151972338.1|9210072_9213483_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972316.1|9176662_9178564_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151972340.1|9214099_9215020_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972346.1|9219259_9219958_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|225076
NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein	unknown	unknown	gnl|CDD|369501
NZ_AP019860.1|WP_151972341.1|9215085_9216171_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein	unknown	unknown	gnl|CDD|380081
NZ_AP019860.1|WP_151972326.1|9189108_9190002_-|hypothetical-protein	unknown	unknown	gnl|CDD|223560
NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NZ_AP019860.1|WP_151972320.1|9181345_9181690_+|hypothetical-protein	unknown	unknown	gnl|CDD|130262
NZ_AP019860.1|WP_151972350.1|9220611_9220947_-|hypothetical-protein	unknown	unknown	gnl|CDD|223059
NZ_AP019860.1|WP_151972348.1|9219969_9220605_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|131575
NZ_AP019860.1|WP_151972337.1|9206824_9209974_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151972345.1|9218603_9219245_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|227305	COG4970, FimT, Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion].	4.52518e-07
NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase	gnl|CDD|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
NZ_AP019860.1|WP_151972318.1|9178940_9181346_+|penicillin-acylase-family-protein	gnl|CDD|376618	pfam01804, Penicil_amidase, Penicillin amidase. Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyzes the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins. Also in the family is cephalosporin acylase and aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	0
NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator	gnl|CDD|223855	COG0784, CheY, FOG: CheY-like receiver [Signal transduction mechanisms].	3.88583e-18
NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein	gnl|CDD|370517	pfam09471, Peptidase_M64, IgA Peptidase M64. This is a family of highly selective metallo-endopeptidases. The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase.	5.1297e-73
NZ_AP019860.1|WP_151972316.1|9176662_9178564_-|tetratricopeptide-repeat-protein	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	4.2232e-37
NZ_AP019860.1|WP_151972346.1|9219259_9219958_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	9.4935e-09
NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein	gnl|CDD|369501	pfam07759, DUF1615, Protein of unknown function (DUF1615). This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family are thought to be lipoproteins. Another member of this family is thought to be involved in photosynthesis.	0.00326073
NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	8.68795e-44
NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein	gnl|CDD|380081	pfam17973, bMG10, Bacterial Alpha-2-macroglobulin MG10 domain. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.	1.23623e-29
NZ_AP019860.1|WP_151972326.1|9189108_9190002_-|hypothetical-protein	gnl|CDD|223560	COG0484, DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones].	2.38997e-07
NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	4.55464e-17
NZ_AP019860.1|WP_151972320.1|9181345_9181690_+|hypothetical-protein	gnl|CDD|130262	TIGR01194, ATP-binding_protein_SyrD, cyclic peptide transporter. This model describes cyclic peptide transporter in bacteria. Bacteria have elaborate pathways for the production of toxins and secondary metabolites. Many such compounds, including syringomycin and pyoverdine are synthesized on non-ribosomal templates consisting of a multienzyme complex. On several occasions the proteins of the complex and transporter protein are present on the same operon. Often times these compounds cross the biological membrane by specific transporters. Syringomycin is an amphipathic, cylclic lipodepsipeptide when inserted into host causes formation of channels, permeable to variety of cations. On the other hand, pyoverdine is a cyclic octa-peptidyl dihydroxyquinoline, which is efficient in sequestering iron for uptake. [Transport and binding proteins, Amino acids, peptides and amines, Transport and binding proteins, Other].	0.00194733
NZ_AP019860.1|WP_151972350.1|9220611_9220947_-|hypothetical-protein	gnl|CDD|223059	PHA03367, PHA03367, single-stranded DNA binding protein; Provisional.	0.00109229
NZ_AP019860.1|WP_151972348.1|9219969_9220605_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|131575	TIGR02523, probable_type-4_fimbrial_biogenesis_protein, type IV pilus modification protein PilV. Pilus systems categorized as type IV pilins differ greatly from one another, with some showing greater similarty to type II or type III secretion systems than to each other. Members of this protein family represent the PilV protein of type IV pilus systems as found in Pseudomonas aeruginosa PAO1, Pseudomonas syringae DC3000, Neisseria meningitidis MC58, Xylella fastidiosa 9a5c, etc. [Cell envelope, Surface structures, Protein fate, Protein modification and repair].	2.28272e-07

Protein sequences

>NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein
MIRGEELEKAWAEFQDSPQNEEQFAVLKESFLGVGDWKKLVELYSLHVGFVEKRDPELGAKLYGERASIEEKYLSRSENAFASYQKSYALQKQNNPYMSSFILLCKSMKNWEVLCNIWEEQLQNSKSDNEKISLLQQLATCHLQEIKNREKAKEIFRRIVDEFPHNEEAFEKLELLYLEDDDYEKLIAMYRQQIQSSSENDIKLKRLQQVASMCEQLQKTDEAIKFYMEILSLQPQQEYALNALESIYTEKQDWQAVLGIMRKKSQSLSEPQLYDYLISMADIAENKLGDNELCVSFLEGAVAKEDFAILTRLEKHYSTLQNWQKLAGVYQKQIELASERKKKREVYFALAKLHEEHNSKSDAIACLYKALEDFPKDKEILERLKSMQSDDEDGLLDIYRLEVNWLQDPAKKVDLWGKMGQILQGKERWNEAIAVYEDILKLDDENLHAYEELQKICAEEDQKEKLLQILVKKSKLVRGEERVEVFNEIAELCTLLRKEDEAIVYYQKIKQLQPNNRKVLYLLADYYREKQEHKQLVAILQQIVNVDKSMYEHGYMEMAEIYENHLNNIDIACKSYEKIIQAVPDNLEAYRRLRSLYKRNNKKAEYLQITSKLASITPKFKEKLDLLFSLCDFYKERDLVSKLEEQLKNVLEVDSHNSRAVESLKALYEKKQDWKKLIAVLQKQSQMCSEIEDVIDIYYKIATFYQEKLRDADQAVLYFEKIKALKPDYVDVLRKLEVLYTQLEAFEKLVKILQQNSYLSVEVSQRVNYIFMAGMILEEKLKEPQRAMWAYENVILNDPYHINALVRLKKLYKGAGDVDKLEAIYEKLSVVTTDNNKLIELYLDAAQICDNKALYYQKIVELDAKNKEALEQLASFYQSDENWEKLIDIRKKQLEICSEKPKIIEYHTHLAHIYKEHVDSPSQAAVHYERILHSDNKNKQAIENLLQIHSENWEKLLGILQLKMRICPEERREILLKIANIYHRKTMQLNEAIKVYNDVLAIDENDRRILEILRNLYGDIEEYPKALQIVNRELKLDISHELKVELLLKKANLAQHHINQPTMAASTLEELLQVDPMHEEAFYRLESLYHKREEYDKLLKVLHNRCEVDEKRRLSLKLNQAYICEKTEKWDEAITTYKEILQLNDKHEEAKKALVSILRTQKKWELLIEFFEEELQKNTDYKAMTDLYNNLGNIWSEQLNKCDEALEMYQQVLELDSSNLLAIRGLQAIYARQKNTEALLKMYIQELEVESIERERRIWLYLMCGDTYEFVLHDWDQAHESYIKVLYNELDPNNLIALRGLQRVYRAQKKYSELQVMLLREFQLQTEDARALQLHLEIAKLKERYLKDPEGSIEYYRVVHEAWPNDIFIINSLETLLHGQKMWNEYVAILEKKIELTKRYKNVLEVHESAMKTYGNYLREWQKAVDHGLAILEIDEGYLPTIQYLQKMYKKMEEEESFAAMCVKEANLIYEIGDRKRICGLYLEAGKIYALLDKKEDAIFCFERILNVNPSHSKALMNLIQIYSATGNWERLINVYEWTAQVSEHEEEVVNLHLKIAYTWEDKLQDNLKALPHYQYAYSKNSQNLAVVKGLRTLYEKMKRWPEAAAMLLEESELEAEEKKAKIFFRLGEIWEKKLNSPIQARDNYLKVIGYGFHRKTSETLVEIQEKLNDYEGMTKILEEDARKCEPQERLNKYLQLGKIYWYKLHKADEAIRTYSKVLKVDSQHPETLKVMAEISKYRKDWKMYIGILNRQTRNTQDPEELYNLCVQLGEVFHEHLGEGNRAIDFYEQALVYKEDLQTIRKLQYVYEEWGCYKKLVDSILSIIDRANGHEKIALYHKLGHIYGERIFDDNSAIGAYENILDIEDDIDACYALAKIYKRQYIWDKLIGIYDKLIADAKLRMDTEEQLKVQLDAAQTYYYYLEDYDKAYNLFKSCLELSPSNDKAFDLLEEILEKRQQYKELANLLTNKMNITEDEQQKITVLHRLANVYIDKLQQPENAVHYYEKILQISETEILALEKLEGLYSQEQNIEALMNVYNLKLKAVEDPAVVSDTYYKLACVYLENYQDTEQATAHLRMSLNEDPGHIDSIKLLADILVEEQNWEQAIDYIQAALGTTKNPQEKYSLLTKVASIYKSSINDLSKAKGYYLQALDIQPKSIEPLSEVIAIYSADEKWKEAEILLERLISVLPEEETDKIVEAYYDWGVAAQKQKKIDQAIGYFKSAVEKNNEHLPSVLSLAKIYFSKQSFHESLTYYEKAYSLESEETNINIIHQSAILHKILGNIDKAIEFYQMLLDRKFSRLETLKSLSSLYSLKKEWDRALLYQQQVVNESPEGEESVAYEEMGDIYKELDNLDKSIDYYLKAIENGKSDIKLKKKLVALYIRQKDWEAARNYNDLCFSELQEAEDKEENRNLHARILIGLGQKREAVHCYQETLKVNPICIKAIKGIAEIYLAEENWSALSNSYREFLTNLPEDKKENGLPIHLALGFLYLEKIQKDDLAIEQFEAVLQLDHDHTEALIALTKIKTKEPASQEEAIKGHFRILKKDSLRVDSYLSLHDLLEKTDKKNRAMKCYRAYQYLSNEKVEVSSKLVPVNNDLISSFIIPKPIQEVREVISTIEDYCEKIYQTNIEEKFDIKKREHLGAERVQRPIWYHTHSIMKAMGIRDLNMYITAKHRNKIFLENTNPPSLIICKNLVDNLSEQYLRFLIAKYLFYVSLKQILVQKLEMHELHEHWKMIYSCFGKNMFDSAEFGVDQKKLRNLIPRKTRKSLEAKEDFWQKFINCDIEQYVRFMDYASNRCAFTVIDSLETSINTIYFWEMGVHVKNKLEELRDMATVHDLLLYNISESYEQVLKQD
>NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein
MAQKYITKDNYLGIKGDLTLPPVCIITGEEVQGESVHSNIVQRFFSPLHVILISVSTVSLFLVPYALLFYVSLYVFYKLCTRNRYPQTIHYYISRRAIRTSMLWNLCAATSFAVLVAYYERIFPGILAAWLIHYMFARTEIYIVKREASYTFLHGISTRARKKILSLNISMANRPFPATASSETLGNDHNLLPPHVIENLSPPSKGNLQPIVKKQSKKTIDISGQNLKYVHQELLEGVVEKDVEEFKASNNPIGQIPPGIFAFENLRNLEMNNTRITFMTGIDKLSRLEKCYVASNRIRKIPDEIRKLSSLTTLDVSSNRLKDIPAEISFTALIELRLHNNFINKVPEQIIHLRSLTILDLSNNKINELPENIGQLKLLQKLYLQNNHLQSLPHSFAQLHQLEELNLGNNQFSEIPQELQHLPKLCHLNISQNEISDISGNNLQNLMNLDVSHNNLSQVTLCFPQLHTINFSHNNLAHVVIDVETSQKLRQIELSHNKLQQLPQEIFHIPSLEKLYLNHNQLQNIPSLENAQQLKKIELRNNDLHEFPKSFANLQHKVHIDVSQNPHIDIPAQHQHEIEYDWSKLNVFDNKQPLNPFIVKTKEHVIELTTTECIPYPDIEKYQQQTYLWQSGHLKPLTKIENTIPENTAIISENKLHFVREKRRFAIKETFAHYSLLLPCPNNDSLSKVFVAYDNRNFCRIEIFEASLSFHKDFITSLQQEIKKQRGQEATTVYTLGQHQQQIYVVTNFYKGVPLQHYIQNNQLSLGETIYWIVQVLSLVKRATIDNNYITLNNINAYHYTLNLVGLETQKARESVQKNISHQGKVQDNKYHFCSPQVLMDKSTPNTQPNLIYSQGIIFFFLLTKRLPFHHTQLLQLILLIIDKQPGDMTIYNHSLKAQPICDIIYKMIAKKPQDRHQNEQQVIADIQKHYPKLFIKHFCIHKQVNSGKYYKMYTGLDTKTAQVSSIITFHDTIQLSSIQKKCIHAYPQIQFFNDNGHNGVAIPHRHLHRITEKQQPLTVVYFALEIIDILQELNAYDLFPILHENMLGIDEKQNLRLNIPEMMQQLATKKEDSTQLVSIEKACNLNNSKEINYRLPDEILTPQYNTTAQIYSLGVTMYNMVSGSYPYTKKELLHMDSSFYHRRILLHSNETPQPLRKIINKAISYLDPTYTKWQQLRQDLHQCYNELKTKLLNSA
>NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein
MLKHTIILFIAMITIICDPYPKEGKVYKNPKDLQDNTTFALAPLMTEQQVFSEAQQVIRVEVEWLSTTDTFRFAYAVIENSGTAALSKRTKNLDTFGSYRGQLVDTNNNAILYYNSLGTGQQYRKLSRSLTFRFPIPQDVVEFQMIAENPQTGIMEHVLTQKIDPQTIPVVKNSMTFNDIEVRVLQQATKLPKLIVNVYAEGYDTSGKNSFWQDAPKVVDRLRSKNFPMFEHLEFRGVFAVSQQKLGSAKKLGFPIPERDSFLGLYYPYWDDFGRWYHVIYPTREKRFRQNIGLVPYDYPIVLVDSSSYWGVGNFKEHTAIPARSSSFTYLLMHEFGHYFGLNEEYDSGGKTELAFAPGIREPWSPNITFLNNKQNVKWKQFTTKGVPIPTPKSYWTGSGPYGAYRGGYAQTPPFGKSYKPGFGCIMNSGSNFCDICRFSITQRIRFDLGLETKPFSFNNTQQCCK
>NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase
MLNIAHFIHNSNMRSPQKTAMRLGEKSFTYQELTALAGKVASFLEAQGIKKGDTVALSCPNVPYFPIVYYGILQLGAVVVPHNVLLKPAEIEYLLNDCEAKAYFAFEGTPELPMGQMAWEGTQKTLCKTFVIMTADPAAPSPIEGATTLGQILATSQPKQEITPTDANDTAVILYTSGTTGKPKGAELTHFNIFMNAQISRDLVADGAGHEDVFMMVLPLFHSFGQVVGMNATFYRGAELVMLPRFDPQVTLQLMYKHKVNIFAGVPTMYWALLNTASKIPEEQLTAVKNNIKVCASGGAALPVEIHQQFKQVFDVEILEGYGLSETSPVASFHHRGRPLKVGSIGEPVWGVEMKVFNEDCEEVPVGEVGEIVIRGHNIMKGYYRRVHETEHAMRSGWFHSGDMGKMDEDGYFYIVDRVKDMIVRGGFNVYPREIEEVLQQHEAVSLVAVIGVPHEQHGEEVKAFVVLNENAHITVDELIAWGKEKMAAYKYPRLIEICTELPMNATGKILKRELRDREAKKQEDNSQE
>NZ_AP019860.1|WP_151972326.1|9189108_9190002_-|hypothetical-protein
MKKPTNSKNTKKPVKKSVAKKPVKKAVSSTNRNVVKKKNVTKAANKKTVSSSTNRNTANKKTVSSSTNRNATNKKTVSSSTNRNTANKKTPSSSTNRNTANKKKETKKPKLRTCSKCSHKVSPSARVCPSCGHPMGFLSWLTENKFLLLITSIVGVNGLWFVDVWDYFAKTEDTEVHATDHNDSTTNNPPVIQNPVVAPDNTKKEKCKVCRGTKKMTCPVCKRYGGQGGIPCSTCRGQGRMRCTKCNGSGRMTVGQASGFCDKCRGSGKTQCNVCRGSRFQRCHSCSNGKVPCNYCY
>NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein
MKLYLSLLFVCFSCIFAQTSDPWAEVSKLEKKQKYKAALKKVDVILDNAQQQKNLTEWRKSLIRKVTLQTALHGYETSVRTLYEEAWPHDGESNSILNMFCAHTLEVYYYAYRWEINNREKVASAKDVDLKKWSKNEIFKRIHKHYYKAYQVRYTLGKLSVKDFKQFIRIGGYPERVRGTMRDFLCYSWAGFIASTQTWTPQQSREKYRIDFEHLLKASDLRERTLDDILLSDVHPILKLVHVLDDVYFWSIDNGRVESALESQLEKIRLLKSFFGEKHHKEKMAKELSFFLEKYSSYPWWAAGMYELAKLQQEQQLGVAAHTTAVKAVEKYPESLGGKKCLTLQKTLEAPAFNIISMGVDHHGEKSLRIQHKNMQKLFFRAYMINFDAFLKRPHRYPGSVYTNDLRQTLDKQRPTHSWSVDLEDLKDFEYHNTYTTAPMKRNGFFAVFASADENFSTSKNAISSTYMLISNMVVLENRKKGGWEAWIVDGKKGTGVAGATVKLYQYNYNVGARLIDTRKTSLSGTAFFRMSGRGSNYFMVAEKDNDVSFDPNTLYFYPSNVSHNRKGSFVYTDRSIYRPLQEIMCKVVTFDGNSLSGKYQAMVDKKVKLSLLDPNWKEVETKTVVTNSYGTASESFTVPQGRLLGLYRLRAVVDGKTSYANVRVEEYKRPTFEVELQKPKEELRLNNEAQITGNARYYFGLPLTTGKVFYRVTRVPVYPYWYWWYYRDLSVQSSDEVASGYTQLDTQGEFKINFTPEANDNLPNKEQISYRFEVYAEITDEGGETRNSSSTYNIGFVAVKAEISLNDKFVSAKETAKINIHLQDLNGVARAGEAQYSLFRVKQPQQAMLPKDLPFEKIPGKKYTPGDLMRPRWEHNRSLQEYLFSFADGEQVKSGSVTHGKNGKANLEFSDLTPGVYRIRYNTKDKFGSAYATQKEFIVADNNARVAVPVFLIPKQNKVSVGGEAVFFLGSGISDQPLSVEVHQNGHMLKRMWIDDASQTRMFKVKVSEKHRGGFSVRIHGVHDYQYYSLTENILVPWDNKELQLNFATFRDVLRPGQKETWTVQVKGPNAEDVAAEVLAYMYDRSLDFFAPHTFTSPATLYPAKYGVEYTRHGLFTRSFYSIVNKGWYTIPAAPSYYRDQFMAFRSYGVGGPGRRQFYRVTTRPEETGPAIHLRSEESLGEEGFADDSSVESGDLGGAVPEGNTVLKQQAVPRAPKVPAQKKKGEEPRVRSNFSETAFFLPHIVTKKGVATIEFEIPDSVTEWKVYVHAITSDLKYMSMNRTTATRKDLMVRPYVPRFFREGDKATLKAVINNATAKQMNGKVTLRILDRNTQKDRSNDFSLQNHEQKWTCAGNGSTNVSWSLTAPSKLGEYAFKVVAVSDNVSDGELRPVPVLPSRIHLSQSRFVTLKNNDMRIMEIKDLRDAEKDASLIHDSLVVNLNGQLIYTVLQALPFLTEYPYECVEQTMNRFVCTGMVTSMYDQYPAMKKMAEEFAAKRDTKYAKWNAPDANRKMALAETPWLVSAEGGSKDNLINVLDPKIANYYRQSSLDKLRKAQLNNGGFPWWTGGPSSAYMTLYLLSSFARALEFKVDIPQDMIKKAWTFMGQHFRDYYEKRMVIENYGYEFITFLNYVLSCYDAKSYQHAFSEKQRWAMLEYSVKHWKDHSPYIKAMLSLTLKRMKRSADAIMVMDSIMDSAITKQDQGTFWAPEDRGWLWYNDTIESHAFILRALMEVQPYNDKHLDGLVLWLLLNKKMNQWKSTRATAEVIYSLVTFMKQQGSLAVQEKAIVHLGGNKNEVVFRPDTYEGGQKQIVVEGKDIQPETMAKVTIEKEGKGYMFASMNWHYSTEKLPDEARGDFLQVTRKYFVRKHQGKEYVLTPLEEVEKVSIGEQLEVHLSIRCKHPMEYVHLRDPRGAGFEPENSVSRHRWEYGIVWYEEIRDSGANFFFERLPQGEYNFTYRVRANMNGDFRVGPATLQSMYAPEFSAFSSGKLISVK
>NZ_AP019860.1|WP_151972322.1|9181970_9182978_+|hypothetical-protein
MVDALKQLDICVDEAKSYPGLTIIPVYSEKQNDFHVPKLFGEALKDGTMKIQEQKNSNVPRLTVDYKGEGYALGIKGHLLIGGGQDRQLYHSCLISQGCYEIPVQCVQHGRWNPGKNKNFTVCSDITSSGLRFNTQNQGQTWEKIRTYESVTHTNSGSESFTCTRTITMGSMEEQSSLMNEQNIKMSKQMIAVRNRAQKMLDDLKNPQPQQIGFFAIQVNPFIWVKEKRIETNYLLEMAGNAMLWKNIHQKAVESIIYDSAICDVDSIVELNDERKAEIAEFIAMVAVEDWEESDFIGQESRFSLMSKQYFGEAIFLDDPEEMPIHLLCSSLKES
>NZ_AP019860.1|WP_151972320.1|9181345_9181690_+|hypothetical-protein
MGNMIGLFVVCGVAQMFFPWWSMAVAAFIFGFVMVEGKNDFVVFAKGFCGVALLWICVAALQFFTTSQIIATRISDLFSLPHPALCIAVCGVVGGVVAGIATFSGCQLRQAMFD
>NZ_AP019860.1|WP_151972318.1|9178940_9181346_+|penicillin-acylase-family-protein
MKWLKFTCSLVVLIFVVITGNSRLPIGNNKALPPLGKFCDPFHGFWANGESKTQTTLSLPALKDEVTVVWDEREIPHIFAKNERDVSIAQGYLTAKYRLWQMDFLARVASGRLCEVVGNRAKKLDEENRRIGLTFAAERTVAALEEKAPQVKKLLDAYCEGVNAYINSLSYEDYPVECKVLDYKPELWSPLKTFLVQKYMAKSLSYRSEDREMNNIIAAYDRKTMENLFPLKNSTSPIIPSGTEWAFTPHGIKDDKNARNTNKIYDIPFPNRPDMIKGSNNWAVSGKKTLSGRPMLSNDPHLKLFMPAIWLEMQLSSPEVNVYGVTIPGLPGIVIGFNENVAWGMTNSVWDVIDWYKIKYKSDKKDFYRFDDKWLPTTKRREVIKIRGEEDYVFDVVYTHHGPVSFDEPVPIALRWTAHDPSLEFKAFYILNRAKNYDDYRKALTYYDSPAQNIVFADVNGDIAITPNGKFPIKPDGFGRMLEDGTTSSTEWKAYVPYEHRPHIKNPESGFVSSANQHPTDDTYPYYYNGRFEYYRNVRINERLAKMQNITIKEFNSLLNDNYNVHASTVLPTLLKMVKGDDADSKSAIEILQKWDYNNDPDKIAPSIFYEWWRSLVPAIWDEFRDGKKYTKPGWHRTVEIIVQDPRSKWFDNVTTEKQETLEELAQNTFSGAVKKLSNAHGTLTSENTKWRWGNHRGCDVNHLMRIGAFSRKDLFVGGGRHIVNATRKNAGPSWRMVVELSSPIKAWGVYPGGQSGNPGSKHYDDFIGKWEQGELYELLFLASPQDRQEKCVRKLVIGAE
>NZ_AP019860.1|WP_151972316.1|9176662_9178564_-|tetratricopeptide-repeat-protein
MSENNSSESNTLQPRVTQVNTIQSPQKAKQEYIRVRKNFHNYYIEYKLQDSGIANLYRAIDQQTTTPVLIREFDATDNEFRDYLSWEYNFLSHINHPNIVKARELIDCGDKIAIVFEFAEGLSLKEILAEERKFSWPDRIAIAYNIANGVNVLNKAGIILRDMKPANIMINQQMNQIKILYHGLENPSNKKNLRITLRNKVDESVMYLSPEQTEGRQSDRSNVFSLGTICYQLFANNKKSPFYSDNPFSCCYMVGSHNPLILEKVINSRDIDKDLRKYISNVIKRAMEKNDKERWVSAEEMAMQLARCYFAVINNDNTLLQKPLGFQPQIDLSGKEVQLQEKEEITSLVLDIDNIDIEIPADDIPINEETPPKKNKKLTNRIQYELPNLQKATQGRKMTLSALVILNVVISCWLILAAPKQNTNEGVTEKPQYTTAKKLFVQKRYLETMRVLQKIMQKEKNNAQLHRDLAACYKIFGEYTKAIHHYEKMLEITPNAEIYYALGNCYAYLLSYNEAISCFKKALKIQPTFTLAAVGMADIFYATRQHTKAIYYYKQALKQATTIDEKAKIHFHIALSFFRQKNYATAVDHYSTAIELKPQEARFYNKRAAAYKQLGKEQLAAKDLATFHSLQIK
>NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator
MHDKKGFTTGEVAELCHVTIPTVIKWIESNELEGFKIPGSKNRRITRENLIKFMKKHNIPIDQLQKNRPKILAVDDEEIILEVFQGIFDEDSYDIRCVSRGFDAGLAKEFKPDVIILDICLPDIDGNTVCEYVRNMPEMKNVRILGISGNITKKELNDLKKRNFDDILAKPFDNDLLFAKVEKLLRK
>NZ_AP019860.1|WP_151972337.1|9206824_9209974_-|hypothetical-protein
MAKIRLSHQSYEKHDCVEIPKNTKITPDIFEYLKKRTLRAQEKNKKILITLPGNTAVSKRSIKEFLQFFQQNKEYLFIPQEALKWGRIWDNIINDDLATTDMDKALAWLADDSFLTPKIVRRELGNVAYIKFSGHVANASKHAAKKIIQSLEEIKPSGRMLEVANVFDTGICNSWVPISGAIVLDIADLFILNQRFLSAITEALEEYNLSVSSKGIFFVTSGLFQSWQLKKILKGQTINEIGNMIRVISSRDSDNESKIQKELAAITSASQKNDPPKPLFLHTVQGHDSALKTIDYFSPDLVIVDEISEATAIKQNVLKSRGEKINHIIPATDPGLRILSPQMITKGYDYDLFAEYVMSRYLHNRGKPNETYIYYLNTDQDRMRKTSMFLGGELSHVIDEDLEQIIEYLPQCETQPDAQGSFTIALLEKQFLKFEVDLHFTVNGFSQLLSKYPNLFTKHKDSLTTSVRLYLKAAQISHPIQAKLHLAESFNEFSITEENINIEIRVQDTRNMLTFKATPHEGLEKRFKTLFTLLNGSDIFDSLPDKELFIELVSLLWENYQASMYRTQGFTISLISENDGSFRLEVFQSKQNKAILSGKVVDGKRQLRFTGNTLHHPQAQKRLLKMISLYFNSGQNDPTENTWRFACFEAMTQVLANGSQNQSLSFDLQVQEPRWAAIIMCDSIAPNMIAERSKKMFDEGADLVKVGDNGRQVTLVRKPDPKETDAVLGFDSLQSELDGLQENAILEKVENVKSQEAEERSLKLQKTYEEALKAYNQKYGGMDDEDDMQATGRTSRPKTLEESARVKVVRRRVMPKGEIEKRRKKMRMYIASGATVFLIAAVLFVSVSFSGRSTGERKALRVKNIDSMSDAELAEMYAKKKKTKSPSKVDKPQKDNKKRDPDPHAQLVKNTCRALYVADAPKQELLNALLKELFFALRKSPNSADAHNLMARLFWYKVHLDTQKIFPKKWKVSWRREAKLHFEKARELYRKDTIQSGISLRIRTWMPEYYIYESNKPKKDKSKKSVFYAKYDVYKEALSDIDLLNSQLR
>NZ_AP019860.1|WP_151972338.1|9210072_9213483_-|hypothetical-protein
MKKLKNKERKGITLIIVTSIMLVLSTTAVTFVRLTGYERTAASNYASTVDAKLTAYAGVDHALALIYDNIRRTGRIGLSEPPVNGVTLQYPANSDRDVFLASQTPEPISLELDIDLYNDGDNNDPFTVSGLVGRTIGGDIFGTSELHGNFYSLKLEDSSGKLNVNSFIPVNVNANGNVTLRTDAATVVPSAETMRRLLLTLAELAFPASDANFHNALASAVLNTPLNPNTRTRFTSMQEVETKINTDVAGFEGSAGAERFLSNLTTSSIIDTSTVAVSVEDALDLRDAPEYYHEARAPVNINTASRDVLIALIVNIRGRANFFASQIQDDDDPTFSNNAIRVETTLRNDIAQFEIAIPQAEAEALADEIIRRREVDGNPFLDQGEIDEFFNAQNINIPVPNLGDPTNGAINAATVVKNTGLNPGSPVVSQQVWNQAVRDMLRSNFNPNTVENFWNPNAGAFRRVSTSDLVRIESDGTNLQTNPSHTLELVPSSVGSVEITSVGRTTAQQGNLVTGISIIETVAEFGREVTHTTQSDFEPDTGLATTVTSPNNIAHQRAVGAPVDEDLFAGAVEPNPILDINGDNPGNGNRTGGGNSFSSGNNFVAAGNNEQQNRFNTNGTYKSPAQWTTQTVNPGGAKTIKYNVRAANNSLIKSFEGLPFIMEAKNTVRQPGNNITYDGLVSRRMYYTPDFVREVSPSDAAIGLRQNDSLERYLIETCFEDFTTSSGGDNVSSYLANRSVGNSQPDLRSGNTSGESKMGNRNGSVQFWVKFDADNTDDINGNSIACGLFGATTASGFRQGRVANDSQGNDLFGRTDIFFREGTQTYLYINALGELRATRLYYALCFPLTGQTPYGAFFDTEVDFANRKVPRRDVIMRTTPFKAHEWYHLRLVWDDTLNGNASIDLFVNDEKVTPNIATIEEVDELAFNNEYCLLNEREPLDGMFINGFPRAQAKKGGYFHFNEDGDHIHMPGNATIDQFISSESKNFATTSGDSRRRFPETTTYTNSFNLNDDDAVIAAIRWTSYPPYRQDADDDSDFPSVRLSSVTVNGTSQGVNQNNTTTEDSQQRELVVAGDIIGNTNINSQQVDYTFEFTSPRPKQPVNNTNELQGARCATLDSVTLLMLKRYPVLRDTEIQ
>NZ_AP019860.1|WP_151972340.1|9214099_9215020_-|hypothetical-protein
MIKKILCIFFITTFISLHSQEATKFVKVKTLDLKVVPYPWANELSLSINIFAKRIFKDVKFQIRLQYEGRKIGSYTVTVKENEGRYYAKKKFEPLNKPAQEVLYGDYNVYIEMVVEEQNSKFKARWKKFSSATRLAIAQKTFSIGKKNQVQKQQKEIQEFYIERMKELNRLYKILKKQEVVEYRNRGFRRQKWRQWLYTEYLQKINNEKKQLEIRQARVYHPKYNYTLNGMKYYCDLLVRIGKTSTMILYKRHGLKQDATSMSGIDPFAIKSRKSLNKIIEGIHRSSAKEMGISLKKELGFIPPPK
>NZ_AP019860.1|WP_151972341.1|9215085_9216171_-|hypothetical-protein
MKKLLTILLILITCIFADKYKVSVDDISQYKVDYKILNPCAVSNDASYFFATERVYDVKKIARGNAYDLIIFRFKDKKLETIDRIPLKIYHLVNVAYDSDRHRIFIVGNRGNKIIRVDPRNNRKKVEFEYQQGQKGFKAGPFVFCHKSKLYATGWFYDEEQNWLGDYVARIAFTKKGVRFQRKASLDYLFKYRFSNRGTVRTNFYVSGDLFYFSLIDQVEKKTFLMELRNKKLTPVDKEHIISTFAATDERIFYITRDADGHYHHFLKNFTTGEKYTIGRENDRFTYPFLVKDRLVVLKTDLKRKTFNAYVGIEKDRYLLQRFIKNETLGAMKISQNAKYYLFMGIDGITIGTLVRNESTE
>NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein
MTASAWCCGVRSINLVQAQNQVQQQQPQPAPPITQPAPAPVPEPETLAEIIKADLADFDKFGSNDQETNFDDNAVERLSEAAIREVERFEEALNLPTFAGDSDESRIDRNEKQLDIAENLAPQLQQRVLEFISDVNNDVSKFVAPENQAILANAPQSVIDSFYDQVSNLHEEFFVDLNNAIKLELQTGIDPNSVSTNTLPDGSTQQETTDNLAQIDDTNSAVPTAQRILDRLQFTQQEFLNDFKFVRESTLEEIQNIETINNDQSSEINTTPDFDGALDSTFQSPTQTNRIRLDVLNPLSLPGANFDRGTASIVSMIQDLQNRFSGSQLARDLDFFLAVFPSSQETAVQDSLEPRTDLFVNGQTTLNDLQDRELNQNDANQLADFETENTFTTSSFAIGLDGRLVGIDQSDDNPVISQSENVTRIQNGSSFNTRTFGGTPGQFESVRITVGDRTYELYDHVFTSPIVLDMDGDGKLEASNGVYLPHVYKDGRVVEFDINGDGFVDLTEWVGKNDGLLIQYDSSKPVSGAQLFGDADGFINGYEKMRSLDADENGTLEGQELSTLSVWQDKNLNAKVDAGEIQSLADLKITELKVEHDNFVSQFTIDGEERTMWDWYPSVFRVKKRK
>NZ_AP019860.1|WP_151972345.1|9218603_9219245_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MLLNKRHFKAFTLIELLVVISIIVMIAAAVLPTTLDFMSKSRLKGAASMIKMACLQARSQAIAQRERQFVVLFTQANSQPDTLVTVPASSFDNVPGATQQQALVNTVQVFDSNENNPNREFESRTQAEKFPDFISVQSLGNVDNYTEPLVLEFSPTGSVRVVTGYTGDLPVPGQPAFTGDVADIMLQQDNGEHIALIDIVNNIGQVRSEIRTP
>NZ_AP019860.1|WP_151972346.1|9219259_9219958_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MRRKLQKGFTLIELLVAVSLMLILMGAIVIIFSRSTQLFNLSEANMNIFQNARVAFDLMAKELASSRGNLQINPTQATPAEQSLLSFRSVITFDGASGPETGLANISYRIIPLEGSDNQRWVLLRNFIVPAIDDPNLDDPNIAPVVANARAVGNDVMCEFIAAPRNGAIPGISFDFASYFDDTSPGGNDRWDILTVNNGNVDAVRVRMDVTDSQSRVTHTVSRVFWVANANN
>NZ_AP019860.1|WP_151972348.1|9219969_9220605_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKNKSTAGFTLIEILISLGILVFGVVGILTLFPAGIKSTKKAAEETYAAFIADSVYASLRASASQMAPGDPLIYFHDGINSGGRVNEYVLPQVDESIGIPSIGANPPTAGPVDNRKTTTTYTAELQAGGDVNFALLGQNANGFNVAVSEDDTGGALAQFSYNIQISYPRQDSTRPQENPKGLFDVMIRIRRSGKLIKRFPSKIFLPTNNDN
>NZ_AP019860.1|WP_151972350.1|9220611_9220947_-|hypothetical-protein
MKCDEFRDKKHQEISSMVRMMHITPSKNFKKNLYKALHHEDTSFWEKFNLIFDYAIYRFVHTPVHTAWMSFLIITTIALPICYFNYMENQIQNQQQALPLWKMPAQITANK

Crispr_ID: NZ_AP019860_49

• CRISPR_ID: NZ_AP019860_49
• CRISPR_location: 9213788-9213884
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_AP019860_49

Consensus_repeat	Method
TGTCATTCCTACGAAAGCAGGAATC	CRISPRCasFinder

spacers of NZ_AP019860_49

>49.1|9213813|47|NZ_AP019860|CRISPRCasFinder
CAGCAACGGATAAACCTCAGTTTTATTGAGACGGAACTACCACAAGG

CRISPR arrays and Neighbor proteins around NZ_AP019860_49

CRISPR arrays

The CRISPR arrays of NZ_AP019860_49

>merge|NZ_AP019860|49|9213788-9213884|CRISPRCasFinder
TGTCATTCCTACGAAAGCAGGAATCCAGCAACGGATAAACCTCAGTTTTATTGAGACGGAACTACCACAAGGTGTCATTCCTGCGAAAGCAGGAATC

>NZ_AP019860|49|41|9213788-9213884|CRISPRCasFinder
TGTCATTCCTACGAAAGCAGGAATC	CAGCAACGGATAAACCTCAGTTTTATTGAGACGGAACTACCACAAGG
TGTCATTCCTGCGAAAGCAGGAATC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_AP019860.1|WP_151972345.1|9218603_9219245_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|227305
NZ_AP019860.1|WP_151972338.1|9210072_9213483_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972351.1|9221014_9225001_+|protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator	unknown	unknown	gnl|CDD|223855
NZ_AP019860.1|WP_151972322.1|9181970_9182978_+|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein	unknown	unknown	gnl|CDD|370517
NZ_AP019860.1|WP_151972346.1|9219259_9219958_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|225076
NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein	unknown	unknown	gnl|CDD|369501
NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|341259
NZ_AP019860.1|WP_151972341.1|9215085_9216171_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275380
NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein	unknown	unknown	gnl|CDD|380081
NZ_AP019860.1|WP_151972326.1|9189108_9190002_-|hypothetical-protein	unknown	unknown	gnl|CDD|223560
NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
NZ_AP019860.1|WP_151972340.1|9214099_9215020_-|hypothetical-protein	unknown	unknown	unknown
NZ_AP019860.1|WP_151972354.1|9225590_9226601_-|type-2-isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl|CDD|239205
NZ_AP019860.1|WP_151972353.1|9225071_9225587_-|macro-domain-containing-protein	unknown	unknown	gnl|CDD|394877
NZ_AP019860.1|WP_151972350.1|9220611_9220947_-|hypothetical-protein	unknown	unknown	gnl|CDD|223059
NZ_AP019860.1|WP_151972348.1|9219969_9220605_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	unknown	unknown	gnl|CDD|131575
NZ_AP019860.1|WP_151972337.1|9206824_9209974_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_AP019860.1|WP_151972345.1|9218603_9219245_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|227305	COG4970, FimT, Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion].	4.52518e-07
NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase	gnl|CDD|341259	cd05936, FC-FACS_FadD_like, Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD. This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.	0
NZ_AP019860.1|WP_151972351.1|9221014_9225001_+|protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	6.09353e-79
NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator	gnl|CDD|223855	COG0784, CheY, FOG: CheY-like receiver [Signal transduction mechanisms].	3.88583e-18
NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein	gnl|CDD|370517	pfam09471, Peptidase_M64, IgA Peptidase M64. This is a family of highly selective metallo-endopeptidases. The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase.	5.1297e-73
NZ_AP019860.1|WP_151972346.1|9219259_9219958_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|225076	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion].	9.4935e-09
NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein	gnl|CDD|369501	pfam07759, DUF1615, Protein of unknown function (DUF1615). This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family are thought to be lipoproteins. Another member of this family is thought to be involved in photosynthesis.	0.00326073
NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	8.68795e-44
NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein	gnl|CDD|380081	pfam17973, bMG10, Bacterial Alpha-2-macroglobulin MG10 domain. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.	1.23623e-29
NZ_AP019860.1|WP_151972326.1|9189108_9190002_-|hypothetical-protein	gnl|CDD|223560	COG0484, DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones].	2.38997e-07
NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	4.55464e-17
NZ_AP019860.1|WP_151972354.1|9225590_9226601_-|type-2-isopentenyl-diphosphate-Delta-isomerase	gnl|CDD|239205	cd02811, IDI-2_FMN, Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal, FMN and NADPH. IDI-2 catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) in the mevalonate pathway.	3.19849e-146
NZ_AP019860.1|WP_151972353.1|9225071_9225587_-|macro-domain-containing-protein	gnl|CDD|394877	cd02907, Macro_Af1521_BAL-like, macrodomain, Af1521-like family. Macrodomains are found in a variety of proteins with diverse cellular functions, as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Macrodomains can recognize ADP-ribose (ADPr) in both its free and protein-linked forms, in related ligands, such as O-acyl-ADP-ribose (OAADPr), and even in ligands unrelated to ADPr. The macrodomains in this family show similarity to Af1521, a protein from Archaeoglobus fulgidus containing a stand-alone macrodomain. Af1521 binds ADP-ribose and exhibits phosphatase activity toward ADP-ribose-1"-monophosphate (Appr-1"-p). Also included in this family are the N-terminal (or first) macrodomains of BAL (B-aggressive lymphoma) proteins which contain multiple macrodomains, such as the first macrodomain of mono-ADP-ribosyltransferase PARP14 (PARP-14, also known as ADP-ribosyltransferase diphtheria toxin-like 8, ATRD8, B aggressive lymphoma protein 2, or BAL2). Most BAL proteins also contain a C-terminal PARP active site and are also named as PARPs. Human BAL1 (or PARP-9) was originally identified as a risk-related gene in diffuse large B-cell lymphoma that promotes malignant B-cell migration. Some BAL family proteins exhibit PARP activity. Poly (ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins. BAL proteins may also function as transcriptional repressors.	5.81077e-25
NZ_AP019860.1|WP_151972350.1|9220611_9220947_-|hypothetical-protein	gnl|CDD|223059	PHA03367, PHA03367, single-stranded DNA binding protein; Provisional.	0.00109229
NZ_AP019860.1|WP_151972348.1|9219969_9220605_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein	gnl|CDD|131575	TIGR02523, probable_type-4_fimbrial_biogenesis_protein, type IV pilus modification protein PilV. Pilus systems categorized as type IV pilins differ greatly from one another, with some showing greater similarty to type II or type III secretion systems than to each other. Members of this protein family represent the PilV protein of type IV pilus systems as found in Pseudomonas aeruginosa PAO1, Pseudomonas syringae DC3000, Neisseria meningitidis MC58, Xylella fastidiosa 9a5c, etc. [Cell envelope, Surface structures, Protein fate, Protein modification and repair].	2.28272e-07

Protein sequences

>NZ_AP019860.1|WP_151972338.1|9210072_9213483_-|hypothetical-protein
MKKLKNKERKGITLIIVTSIMLVLSTTAVTFVRLTGYERTAASNYASTVDAKLTAYAGVDHALALIYDNIRRTGRIGLSEPPVNGVTLQYPANSDRDVFLASQTPEPISLELDIDLYNDGDNNDPFTVSGLVGRTIGGDIFGTSELHGNFYSLKLEDSSGKLNVNSFIPVNVNANGNVTLRTDAATVVPSAETMRRLLLTLAELAFPASDANFHNALASAVLNTPLNPNTRTRFTSMQEVETKINTDVAGFEGSAGAERFLSNLTTSSIIDTSTVAVSVEDALDLRDAPEYYHEARAPVNINTASRDVLIALIVNIRGRANFFASQIQDDDDPTFSNNAIRVETTLRNDIAQFEIAIPQAEAEALADEIIRRREVDGNPFLDQGEIDEFFNAQNINIPVPNLGDPTNGAINAATVVKNTGLNPGSPVVSQQVWNQAVRDMLRSNFNPNTVENFWNPNAGAFRRVSTSDLVRIESDGTNLQTNPSHTLELVPSSVGSVEITSVGRTTAQQGNLVTGISIIETVAEFGREVTHTTQSDFEPDTGLATTVTSPNNIAHQRAVGAPVDEDLFAGAVEPNPILDINGDNPGNGNRTGGGNSFSSGNNFVAAGNNEQQNRFNTNGTYKSPAQWTTQTVNPGGAKTIKYNVRAANNSLIKSFEGLPFIMEAKNTVRQPGNNITYDGLVSRRMYYTPDFVREVSPSDAAIGLRQNDSLERYLIETCFEDFTTSSGGDNVSSYLANRSVGNSQPDLRSGNTSGESKMGNRNGSVQFWVKFDADNTDDINGNSIACGLFGATTASGFRQGRVANDSQGNDLFGRTDIFFREGTQTYLYINALGELRATRLYYALCFPLTGQTPYGAFFDTEVDFANRKVPRRDVIMRTTPFKAHEWYHLRLVWDDTLNGNASIDLFVNDEKVTPNIATIEEVDELAFNNEYCLLNEREPLDGMFINGFPRAQAKKGGYFHFNEDGDHIHMPGNATIDQFISSESKNFATTSGDSRRRFPETTTYTNSFNLNDDDAVIAAIRWTSYPPYRQDADDDSDFPSVRLSSVTVNGTSQGVNQNNTTTEDSQQRELVVAGDIIGNTNINSQQVDYTFEFTSPRPKQPVNNTNELQGARCATLDSVTLLMLKRYPVLRDTEIQ
>NZ_AP019860.1|WP_151972337.1|9206824_9209974_-|hypothetical-protein
MAKIRLSHQSYEKHDCVEIPKNTKITPDIFEYLKKRTLRAQEKNKKILITLPGNTAVSKRSIKEFLQFFQQNKEYLFIPQEALKWGRIWDNIINDDLATTDMDKALAWLADDSFLTPKIVRRELGNVAYIKFSGHVANASKHAAKKIIQSLEEIKPSGRMLEVANVFDTGICNSWVPISGAIVLDIADLFILNQRFLSAITEALEEYNLSVSSKGIFFVTSGLFQSWQLKKILKGQTINEIGNMIRVISSRDSDNESKIQKELAAITSASQKNDPPKPLFLHTVQGHDSALKTIDYFSPDLVIVDEISEATAIKQNVLKSRGEKINHIIPATDPGLRILSPQMITKGYDYDLFAEYVMSRYLHNRGKPNETYIYYLNTDQDRMRKTSMFLGGELSHVIDEDLEQIIEYLPQCETQPDAQGSFTIALLEKQFLKFEVDLHFTVNGFSQLLSKYPNLFTKHKDSLTTSVRLYLKAAQISHPIQAKLHLAESFNEFSITEENINIEIRVQDTRNMLTFKATPHEGLEKRFKTLFTLLNGSDIFDSLPDKELFIELVSLLWENYQASMYRTQGFTISLISENDGSFRLEVFQSKQNKAILSGKVVDGKRQLRFTGNTLHHPQAQKRLLKMISLYFNSGQNDPTENTWRFACFEAMTQVLANGSQNQSLSFDLQVQEPRWAAIIMCDSIAPNMIAERSKKMFDEGADLVKVGDNGRQVTLVRKPDPKETDAVLGFDSLQSELDGLQENAILEKVENVKSQEAEERSLKLQKTYEEALKAYNQKYGGMDDEDDMQATGRTSRPKTLEESARVKVVRRRVMPKGEIEKRRKKMRMYIASGATVFLIAAVLFVSVSFSGRSTGERKALRVKNIDSMSDAELAEMYAKKKKTKSPSKVDKPQKDNKKRDPDPHAQLVKNTCRALYVADAPKQELLNALLKELFFALRKSPNSADAHNLMARLFWYKVHLDTQKIFPKKWKVSWRREAKLHFEKARELYRKDTIQSGISLRIRTWMPEYYIYESNKPKKDKSKKSVFYAKYDVYKEALSDIDLLNSQLR
>NZ_AP019860.1|WP_151972335.1|9206166_9206730_+|response-regulator
MHDKKGFTTGEVAELCHVTIPTVIKWIESNELEGFKIPGSKNRRITRENLIKFMKKHNIPIDQLQKNRPKILAVDDEEIILEVFQGIFDEDSYDIRCVSRGFDAGLAKEFKPDVIILDICLPDIDGNTVCEYVRNMPEMKNVRILGISGNITKKELNDLKKRNFDDILAKPFDNDLLFAKVEKLLRK
>NZ_AP019860.1|WP_151972334.1|9197208_9205776_+|tetratricopeptide-repeat-protein
MIRGEELEKAWAEFQDSPQNEEQFAVLKESFLGVGDWKKLVELYSLHVGFVEKRDPELGAKLYGERASIEEKYLSRSENAFASYQKSYALQKQNNPYMSSFILLCKSMKNWEVLCNIWEEQLQNSKSDNEKISLLQQLATCHLQEIKNREKAKEIFRRIVDEFPHNEEAFEKLELLYLEDDDYEKLIAMYRQQIQSSSENDIKLKRLQQVASMCEQLQKTDEAIKFYMEILSLQPQQEYALNALESIYTEKQDWQAVLGIMRKKSQSLSEPQLYDYLISMADIAENKLGDNELCVSFLEGAVAKEDFAILTRLEKHYSTLQNWQKLAGVYQKQIELASERKKKREVYFALAKLHEEHNSKSDAIACLYKALEDFPKDKEILERLKSMQSDDEDGLLDIYRLEVNWLQDPAKKVDLWGKMGQILQGKERWNEAIAVYEDILKLDDENLHAYEELQKICAEEDQKEKLLQILVKKSKLVRGEERVEVFNEIAELCTLLRKEDEAIVYYQKIKQLQPNNRKVLYLLADYYREKQEHKQLVAILQQIVNVDKSMYEHGYMEMAEIYENHLNNIDIACKSYEKIIQAVPDNLEAYRRLRSLYKRNNKKAEYLQITSKLASITPKFKEKLDLLFSLCDFYKERDLVSKLEEQLKNVLEVDSHNSRAVESLKALYEKKQDWKKLIAVLQKQSQMCSEIEDVIDIYYKIATFYQEKLRDADQAVLYFEKIKALKPDYVDVLRKLEVLYTQLEAFEKLVKILQQNSYLSVEVSQRVNYIFMAGMILEEKLKEPQRAMWAYENVILNDPYHINALVRLKKLYKGAGDVDKLEAIYEKLSVVTTDNNKLIELYLDAAQICDNKALYYQKIVELDAKNKEALEQLASFYQSDENWEKLIDIRKKQLEICSEKPKIIEYHTHLAHIYKEHVDSPSQAAVHYERILHSDNKNKQAIENLLQIHSENWEKLLGILQLKMRICPEERREILLKIANIYHRKTMQLNEAIKVYNDVLAIDENDRRILEILRNLYGDIEEYPKALQIVNRELKLDISHELKVELLLKKANLAQHHINQPTMAASTLEELLQVDPMHEEAFYRLESLYHKREEYDKLLKVLHNRCEVDEKRRLSLKLNQAYICEKTEKWDEAITTYKEILQLNDKHEEAKKALVSILRTQKKWELLIEFFEEELQKNTDYKAMTDLYNNLGNIWSEQLNKCDEALEMYQQVLELDSSNLLAIRGLQAIYARQKNTEALLKMYIQELEVESIERERRIWLYLMCGDTYEFVLHDWDQAHESYIKVLYNELDPNNLIALRGLQRVYRAQKKYSELQVMLLREFQLQTEDARALQLHLEIAKLKERYLKDPEGSIEYYRVVHEAWPNDIFIINSLETLLHGQKMWNEYVAILEKKIELTKRYKNVLEVHESAMKTYGNYLREWQKAVDHGLAILEIDEGYLPTIQYLQKMYKKMEEEESFAAMCVKEANLIYEIGDRKRICGLYLEAGKIYALLDKKEDAIFCFERILNVNPSHSKALMNLIQIYSATGNWERLINVYEWTAQVSEHEEEVVNLHLKIAYTWEDKLQDNLKALPHYQYAYSKNSQNLAVVKGLRTLYEKMKRWPEAAAMLLEESELEAEEKKAKIFFRLGEIWEKKLNSPIQARDNYLKVIGYGFHRKTSETLVEIQEKLNDYEGMTKILEEDARKCEPQERLNKYLQLGKIYWYKLHKADEAIRTYSKVLKVDSQHPETLKVMAEISKYRKDWKMYIGILNRQTRNTQDPEELYNLCVQLGEVFHEHLGEGNRAIDFYEQALVYKEDLQTIRKLQYVYEEWGCYKKLVDSILSIIDRANGHEKIALYHKLGHIYGERIFDDNSAIGAYENILDIEDDIDACYALAKIYKRQYIWDKLIGIYDKLIADAKLRMDTEEQLKVQLDAAQTYYYYLEDYDKAYNLFKSCLELSPSNDKAFDLLEEILEKRQQYKELANLLTNKMNITEDEQQKITVLHRLANVYIDKLQQPENAVHYYEKILQISETEILALEKLEGLYSQEQNIEALMNVYNLKLKAVEDPAVVSDTYYKLACVYLENYQDTEQATAHLRMSLNEDPGHIDSIKLLADILVEEQNWEQAIDYIQAALGTTKNPQEKYSLLTKVASIYKSSINDLSKAKGYYLQALDIQPKSIEPLSEVIAIYSADEKWKEAEILLERLISVLPEEETDKIVEAYYDWGVAAQKQKKIDQAIGYFKSAVEKNNEHLPSVLSLAKIYFSKQSFHESLTYYEKAYSLESEETNINIIHQSAILHKILGNIDKAIEFYQMLLDRKFSRLETLKSLSSLYSLKKEWDRALLYQQQVVNESPEGEESVAYEEMGDIYKELDNLDKSIDYYLKAIENGKSDIKLKKKLVALYIRQKDWEAARNYNDLCFSELQEAEDKEENRNLHARILIGLGQKREAVHCYQETLKVNPICIKAIKGIAEIYLAEENWSALSNSYREFLTNLPEDKKENGLPIHLALGFLYLEKIQKDDLAIEQFEAVLQLDHDHTEALIALTKIKTKEPASQEEAIKGHFRILKKDSLRVDSYLSLHDLLEKTDKKNRAMKCYRAYQYLSNEKVEVSSKLVPVNNDLISSFIIPKPIQEVREVISTIEDYCEKIYQTNIEEKFDIKKREHLGAERVQRPIWYHTHSIMKAMGIRDLNMYITAKHRNKIFLENTNPPSLIICKNLVDNLSEQYLRFLIAKYLFYVSLKQILVQKLEMHELHEHWKMIYSCFGKNMFDSAEFGVDQKKLRNLIPRKTRKSLEAKEDFWQKFINCDIEQYVRFMDYASNRCAFTVIDSLETSINTIYFWEMGVHVKNKLEELRDMATVHDLLLYNISESYEQVLKQD
>NZ_AP019860.1|WP_151972332.1|9193282_9196873_-|leucine-rich-repeat-domain-containing-protein
MAQKYITKDNYLGIKGDLTLPPVCIITGEEVQGESVHSNIVQRFFSPLHVILISVSTVSLFLVPYALLFYVSLYVFYKLCTRNRYPQTIHYYISRRAIRTSMLWNLCAATSFAVLVAYYERIFPGILAAWLIHYMFARTEIYIVKREASYTFLHGISTRARKKILSLNISMANRPFPATASSETLGNDHNLLPPHVIENLSPPSKGNLQPIVKKQSKKTIDISGQNLKYVHQELLEGVVEKDVEEFKASNNPIGQIPPGIFAFENLRNLEMNNTRITFMTGIDKLSRLEKCYVASNRIRKIPDEIRKLSSLTTLDVSSNRLKDIPAEISFTALIELRLHNNFINKVPEQIIHLRSLTILDLSNNKINELPENIGQLKLLQKLYLQNNHLQSLPHSFAQLHQLEELNLGNNQFSEIPQELQHLPKLCHLNISQNEISDISGNNLQNLMNLDVSHNNLSQVTLCFPQLHTINFSHNNLAHVVIDVETSQKLRQIELSHNKLQQLPQEIFHIPSLEKLYLNHNQLQNIPSLENAQQLKKIELRNNDLHEFPKSFANLQHKVHIDVSQNPHIDIPAQHQHEIEYDWSKLNVFDNKQPLNPFIVKTKEHVIELTTTECIPYPDIEKYQQQTYLWQSGHLKPLTKIENTIPENTAIISENKLHFVREKRRFAIKETFAHYSLLLPCPNNDSLSKVFVAYDNRNFCRIEIFEASLSFHKDFITSLQQEIKKQRGQEATTVYTLGQHQQQIYVVTNFYKGVPLQHYIQNNQLSLGETIYWIVQVLSLVKRATIDNNYITLNNINAYHYTLNLVGLETQKARESVQKNISHQGKVQDNKYHFCSPQVLMDKSTPNTQPNLIYSQGIIFFFLLTKRLPFHHTQLLQLILLIIDKQPGDMTIYNHSLKAQPICDIIYKMIAKKPQDRHQNEQQVIADIQKHYPKLFIKHFCIHKQVNSGKYYKMYTGLDTKTAQVSSIITFHDTIQLSSIQKKCIHAYPQIQFFNDNGHNGVAIPHRHLHRITEKQQPLTVVYFALEIIDILQELNAYDLFPILHENMLGIDEKQNLRLNIPEMMQQLATKKEDSTQLVSIEKACNLNNSKEINYRLPDEILTPQYNTTAQIYSLGVTMYNMVSGSYPYTKKELLHMDSSFYHRRILLHSNETPQPLRKIINKAISYLDPTYTKWQQLRQDLHQCYNELKTKLLNSA
>NZ_AP019860.1|WP_151972330.1|9191695_9193096_-|hypothetical-protein
MLKHTIILFIAMITIICDPYPKEGKVYKNPKDLQDNTTFALAPLMTEQQVFSEAQQVIRVEVEWLSTTDTFRFAYAVIENSGTAALSKRTKNLDTFGSYRGQLVDTNNNAILYYNSLGTGQQYRKLSRSLTFRFPIPQDVVEFQMIAENPQTGIMEHVLTQKIDPQTIPVVKNSMTFNDIEVRVLQQATKLPKLIVNVYAEGYDTSGKNSFWQDAPKVVDRLRSKNFPMFEHLEFRGVFAVSQQKLGSAKKLGFPIPERDSFLGLYYPYWDDFGRWYHVIYPTREKRFRQNIGLVPYDYPIVLVDSSSYWGVGNFKEHTAIPARSSSFTYLLMHEFGHYFGLNEEYDSGGKTELAFAPGIREPWSPNITFLNNKQNVKWKQFTTKGVPIPTPKSYWTGSGPYGAYRGGYAQTPPFGKSYKPGFGCIMNSGSNFCDICRFSITQRIRFDLGLETKPFSFNNTQQCCK
>NZ_AP019860.1|WP_151972328.1|9190092_9191682_-|long-chain-fatty-acid--CoA-ligase
MLNIAHFIHNSNMRSPQKTAMRLGEKSFTYQELTALAGKVASFLEAQGIKKGDTVALSCPNVPYFPIVYYGILQLGAVVVPHNVLLKPAEIEYLLNDCEAKAYFAFEGTPELPMGQMAWEGTQKTLCKTFVIMTADPAAPSPIEGATTLGQILATSQPKQEITPTDANDTAVILYTSGTTGKPKGAELTHFNIFMNAQISRDLVADGAGHEDVFMMVLPLFHSFGQVVGMNATFYRGAELVMLPRFDPQVTLQLMYKHKVNIFAGVPTMYWALLNTASKIPEEQLTAVKNNIKVCASGGAALPVEIHQQFKQVFDVEILEGYGLSETSPVASFHHRGRPLKVGSIGEPVWGVEMKVFNEDCEEVPVGEVGEIVIRGHNIMKGYYRRVHETEHAMRSGWFHSGDMGKMDEDGYFYIVDRVKDMIVRGGFNVYPREIEEVLQQHEAVSLVAVIGVPHEQHGEEVKAFVVLNENAHITVDELIAWGKEKMAAYKYPRLIEICTELPMNATGKILKRELRDREAKKQEDNSQE
>NZ_AP019860.1|WP_151972326.1|9189108_9190002_-|hypothetical-protein
MKKPTNSKNTKKPVKKSVAKKPVKKAVSSTNRNVVKKKNVTKAANKKTVSSSTNRNTANKKTVSSSTNRNATNKKTVSSSTNRNTANKKTPSSSTNRNTANKKKETKKPKLRTCSKCSHKVSPSARVCPSCGHPMGFLSWLTENKFLLLITSIVGVNGLWFVDVWDYFAKTEDTEVHATDHNDSTTNNPPVIQNPVVAPDNTKKEKCKVCRGTKKMTCPVCKRYGGQGGIPCSTCRGQGRMRCTKCNGSGRMTVGQASGFCDKCRGSGKTQCNVCRGSRFQRCHSCSNGKVPCNYCY
>NZ_AP019860.1|WP_151972324.1|9183064_9189055_+|hypothetical-protein
MKLYLSLLFVCFSCIFAQTSDPWAEVSKLEKKQKYKAALKKVDVILDNAQQQKNLTEWRKSLIRKVTLQTALHGYETSVRTLYEEAWPHDGESNSILNMFCAHTLEVYYYAYRWEINNREKVASAKDVDLKKWSKNEIFKRIHKHYYKAYQVRYTLGKLSVKDFKQFIRIGGYPERVRGTMRDFLCYSWAGFIASTQTWTPQQSREKYRIDFEHLLKASDLRERTLDDILLSDVHPILKLVHVLDDVYFWSIDNGRVESALESQLEKIRLLKSFFGEKHHKEKMAKELSFFLEKYSSYPWWAAGMYELAKLQQEQQLGVAAHTTAVKAVEKYPESLGGKKCLTLQKTLEAPAFNIISMGVDHHGEKSLRIQHKNMQKLFFRAYMINFDAFLKRPHRYPGSVYTNDLRQTLDKQRPTHSWSVDLEDLKDFEYHNTYTTAPMKRNGFFAVFASADENFSTSKNAISSTYMLISNMVVLENRKKGGWEAWIVDGKKGTGVAGATVKLYQYNYNVGARLIDTRKTSLSGTAFFRMSGRGSNYFMVAEKDNDVSFDPNTLYFYPSNVSHNRKGSFVYTDRSIYRPLQEIMCKVVTFDGNSLSGKYQAMVDKKVKLSLLDPNWKEVETKTVVTNSYGTASESFTVPQGRLLGLYRLRAVVDGKTSYANVRVEEYKRPTFEVELQKPKEELRLNNEAQITGNARYYFGLPLTTGKVFYRVTRVPVYPYWYWWYYRDLSVQSSDEVASGYTQLDTQGEFKINFTPEANDNLPNKEQISYRFEVYAEITDEGGETRNSSSTYNIGFVAVKAEISLNDKFVSAKETAKINIHLQDLNGVARAGEAQYSLFRVKQPQQAMLPKDLPFEKIPGKKYTPGDLMRPRWEHNRSLQEYLFSFADGEQVKSGSVTHGKNGKANLEFSDLTPGVYRIRYNTKDKFGSAYATQKEFIVADNNARVAVPVFLIPKQNKVSVGGEAVFFLGSGISDQPLSVEVHQNGHMLKRMWIDDASQTRMFKVKVSEKHRGGFSVRIHGVHDYQYYSLTENILVPWDNKELQLNFATFRDVLRPGQKETWTVQVKGPNAEDVAAEVLAYMYDRSLDFFAPHTFTSPATLYPAKYGVEYTRHGLFTRSFYSIVNKGWYTIPAAPSYYRDQFMAFRSYGVGGPGRRQFYRVTTRPEETGPAIHLRSEESLGEEGFADDSSVESGDLGGAVPEGNTVLKQQAVPRAPKVPAQKKKGEEPRVRSNFSETAFFLPHIVTKKGVATIEFEIPDSVTEWKVYVHAITSDLKYMSMNRTTATRKDLMVRPYVPRFFREGDKATLKAVINNATAKQMNGKVTLRILDRNTQKDRSNDFSLQNHEQKWTCAGNGSTNVSWSLTAPSKLGEYAFKVVAVSDNVSDGELRPVPVLPSRIHLSQSRFVTLKNNDMRIMEIKDLRDAEKDASLIHDSLVVNLNGQLIYTVLQALPFLTEYPYECVEQTMNRFVCTGMVTSMYDQYPAMKKMAEEFAAKRDTKYAKWNAPDANRKMALAETPWLVSAEGGSKDNLINVLDPKIANYYRQSSLDKLRKAQLNNGGFPWWTGGPSSAYMTLYLLSSFARALEFKVDIPQDMIKKAWTFMGQHFRDYYEKRMVIENYGYEFITFLNYVLSCYDAKSYQHAFSEKQRWAMLEYSVKHWKDHSPYIKAMLSLTLKRMKRSADAIMVMDSIMDSAITKQDQGTFWAPEDRGWLWYNDTIESHAFILRALMEVQPYNDKHLDGLVLWLLLNKKMNQWKSTRATAEVIYSLVTFMKQQGSLAVQEKAIVHLGGNKNEVVFRPDTYEGGQKQIVVEGKDIQPETMAKVTIEKEGKGYMFASMNWHYSTEKLPDEARGDFLQVTRKYFVRKHQGKEYVLTPLEEVEKVSIGEQLEVHLSIRCKHPMEYVHLRDPRGAGFEPENSVSRHRWEYGIVWYEEIRDSGANFFFERLPQGEYNFTYRVRANMNGDFRVGPATLQSMYAPEFSAFSSGKLISVK
>NZ_AP019860.1|WP_151972322.1|9181970_9182978_+|hypothetical-protein
MVDALKQLDICVDEAKSYPGLTIIPVYSEKQNDFHVPKLFGEALKDGTMKIQEQKNSNVPRLTVDYKGEGYALGIKGHLLIGGGQDRQLYHSCLISQGCYEIPVQCVQHGRWNPGKNKNFTVCSDITSSGLRFNTQNQGQTWEKIRTYESVTHTNSGSESFTCTRTITMGSMEEQSSLMNEQNIKMSKQMIAVRNRAQKMLDDLKNPQPQQIGFFAIQVNPFIWVKEKRIETNYLLEMAGNAMLWKNIHQKAVESIIYDSAICDVDSIVELNDERKAEIAEFIAMVAVEDWEESDFIGQESRFSLMSKQYFGEAIFLDDPEEMPIHLLCSSLKES
>NZ_AP019860.1|WP_151972340.1|9214099_9215020_-|hypothetical-protein
MIKKILCIFFITTFISLHSQEATKFVKVKTLDLKVVPYPWANELSLSINIFAKRIFKDVKFQIRLQYEGRKIGSYTVTVKENEGRYYAKKKFEPLNKPAQEVLYGDYNVYIEMVVEEQNSKFKARWKKFSSATRLAIAQKTFSIGKKNQVQKQQKEIQEFYIERMKELNRLYKILKKQEVVEYRNRGFRRQKWRQWLYTEYLQKINNEKKQLEIRQARVYHPKYNYTLNGMKYYCDLLVRIGKTSTMILYKRHGLKQDATSMSGIDPFAIKSRKSLNKIIEGIHRSSAKEMGISLKKELGFIPPPK
>NZ_AP019860.1|WP_151972341.1|9215085_9216171_-|hypothetical-protein
MKKLLTILLILITCIFADKYKVSVDDISQYKVDYKILNPCAVSNDASYFFATERVYDVKKIARGNAYDLIIFRFKDKKLETIDRIPLKIYHLVNVAYDSDRHRIFIVGNRGNKIIRVDPRNNRKKVEFEYQQGQKGFKAGPFVFCHKSKLYATGWFYDEEQNWLGDYVARIAFTKKGVRFQRKASLDYLFKYRFSNRGTVRTNFYVSGDLFYFSLIDQVEKKTFLMELRNKKLTPVDKEHIISTFAATDERIFYITRDADGHYHHFLKNFTTGEKYTIGRENDRFTYPFLVKDRLVVLKTDLKRKTFNAYVGIEKDRYLLQRFIKNETLGAMKISQNAKYYLFMGIDGITIGTLVRNESTE
>NZ_AP019860.1|WP_173013705.1|9216337_9218218_-|hypothetical-protein
MTASAWCCGVRSINLVQAQNQVQQQQPQPAPPITQPAPAPVPEPETLAEIIKADLADFDKFGSNDQETNFDDNAVERLSEAAIREVERFEEALNLPTFAGDSDESRIDRNEKQLDIAENLAPQLQQRVLEFISDVNNDVSKFVAPENQAILANAPQSVIDSFYDQVSNLHEEFFVDLNNAIKLELQTGIDPNSVSTNTLPDGSTQQETTDNLAQIDDTNSAVPTAQRILDRLQFTQQEFLNDFKFVRESTLEEIQNIETINNDQSSEINTTPDFDGALDSTFQSPTQTNRIRLDVLNPLSLPGANFDRGTASIVSMIQDLQNRFSGSQLARDLDFFLAVFPSSQETAVQDSLEPRTDLFVNGQTTLNDLQDRELNQNDANQLADFETENTFTTSSFAIGLDGRLVGIDQSDDNPVISQSENVTRIQNGSSFNTRTFGGTPGQFESVRITVGDRTYELYDHVFTSPIVLDMDGDGKLEASNGVYLPHVYKDGRVVEFDINGDGFVDLTEWVGKNDGLLIQYDSSKPVSGAQLFGDADGFINGYEKMRSLDADENGTLEGQELSTLSVWQDKNLNAKVDAGEIQSLADLKITELKVEHDNFVSQFTIDGEERTMWDWYPSVFRVKKRK
>NZ_AP019860.1|WP_151972345.1|9218603_9219245_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MLLNKRHFKAFTLIELLVVISIIVMIAAAVLPTTLDFMSKSRLKGAASMIKMACLQARSQAIAQRERQFVVLFTQANSQPDTLVTVPASSFDNVPGATQQQALVNTVQVFDSNENNPNREFESRTQAEKFPDFISVQSLGNVDNYTEPLVLEFSPTGSVRVVTGYTGDLPVPGQPAFTGDVADIMLQQDNGEHIALIDIVNNIGQVRSEIRTP
>NZ_AP019860.1|WP_151972346.1|9219259_9219958_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MRRKLQKGFTLIELLVAVSLMLILMGAIVIIFSRSTQLFNLSEANMNIFQNARVAFDLMAKELASSRGNLQINPTQATPAEQSLLSFRSVITFDGASGPETGLANISYRIIPLEGSDNQRWVLLRNFIVPAIDDPNLDDPNIAPVVANARAVGNDVMCEFIAAPRNGAIPGISFDFASYFDDTSPGGNDRWDILTVNNGNVDAVRVRMDVTDSQSRVTHTVSRVFWVANANN
>NZ_AP019860.1|WP_151972348.1|9219969_9220605_+|prepilin-type-N-terminal-cleavage/methylation-domain-containing-protein
MKNKSTAGFTLIEILISLGILVFGVVGILTLFPAGIKSTKKAAEETYAAFIADSVYASLRASASQMAPGDPLIYFHDGINSGGRVNEYVLPQVDESIGIPSIGANPPTAGPVDNRKTTTTYTAELQAGGDVNFALLGQNANGFNVAVSEDDTGGALAQFSYNIQISYPRQDSTRPQENPKGLFDVMIRIRRSGKLIKRFPSKIFLPTNNDN
>NZ_AP019860.1|WP_151972350.1|9220611_9220947_-|hypothetical-protein
MKCDEFRDKKHQEISSMVRMMHITPSKNFKKNLYKALHHEDTSFWEKFNLIFDYAIYRFVHTPVHTAWMSFLIITTIALPICYFNYMENQIQNQQQALPLWKMPAQITANK
>NZ_AP019860.1|WP_151972351.1|9221014_9225001_+|protein-kinase
MSNNTLPTLPDGYEFVQELGRGAQGSVWLVRNNNTGGRYEACKIVTSISPKELSRFKREIQILATLNHPNIITMYYANPKEKFFLMEYVAGGNLYHYCRKKVLNLKQRIELFLGITEGLAFAHKKGLVHRDLKPENIVMSEDGIAKITDFGISRLSDSSSQTMNITSGTPSYMAPELWSQNPPDKRSDLWSLGIILYEMLTGKCPFKGTVQEICYMVTQGNLKAPHVVSSLPPLGQKLSAICMKALKQDPGKRYHHCEEMIADIKRCLEQGDDIVESPTSIGLSTDLAFKDDDADEVQLHESSADAALEDDLDLEPAETQPAVQAKAPAPVVAKKPVSTSGLDFEENDALPPAGDPLEILPEEGGVAAAPQNLFEKHKYPIVGAAAILVMIIGLILMMPKSLAALQEDLLSQDIEKQQDAFSELKLRGEDAVEVLVYGLNSPQVKMRKDIITHISKYPQSASFYLVEVVEDYANAFTHQARIYAVRALGDLNVDSEITLQGLLAKSSTPEDLRQEAIQSLVKLKPDTYKKKYHFMGGLWLSTRDLRKQGYIETENGWILVSKLFSDLEDKVSQTSVGRKNLEKIRESILSDLQQDKNVQLKDFLSEWDKFFGQYGDIAAEFSKLSNSIEGNLSVETKYKNDITKSLVDLHTDNMEFVDNLISLKQQGIAIQVMQKELENVSEIVTWDKIDFPSEKAQELKQRHHEIVKDSTLYVYTKFNFFGDYDTTDFRDQVMSGIEKSIIRANVYPKFSSRTPQQDRPKHWIVCEYREANIGSYFGNRDKKRKHIRRLRALCNVSYWVESNKVKNWEDVISSNIYLELSKKQTGDLQEAICNMVRNDLKEKFVTWEPKKFDQRKINRDGENTQKVRGSTVYSQKALDIIYTKSKRKMKGLIKKESSRYIHFVVVKIAKGKTSFVEVKIAKSKIAKVKRISDEIRQQRLQDLENIGKQNIVDRKKIDLVPLEKVAWEFGKGTGLVYTSKHFVLYCNTPEEFTREIAFRTESIFEAYKQFFPITRNSDQKIKIYIFNSTAEYQRYIGKAFSNPAYYSPTHNHIVASCDLSSYKSEITKIKQHHDKIRASIAKNEQSIARYRNQITQQKRRLHDDLDKRLARGQIKQRDYDNAYRNIRSQITNINKQVNSILRDQKKLKSEVRRYDYQNSKLIPKYVDSMVEMMYHEAFHAFLKNFLFTEEQTMYVPRWLNEGLAQYFESSFFSNDRLIIGEMDKDRLRFLKKFTKRNNAVAIKDLLVAGYKDFMVMSSDNLENSNLHYIQSWAVVYYIATLFDLRKGDVFGPYVRNIWSGKDQVKAFEELVGMPVEKFEKKWLEFFQK
>NZ_AP019860.1|WP_151972353.1|9225071_9225587_-|macro-domain-containing-protein
MKEKIVILQNDIWNMEVDAIICHANTELEMCEAISSQLLEYGGDEIQNECNSFDQLFKGQAVITTAGQLPAQNLIHAIVHNLGEDFNDGEEEFLMKAIRESFIIIREKKLKTIALPLIGSSSLNIPVKRAAELIMAEIKKHLDGETCVENVYFVAQNYIVYDAIDEAHRQL
>NZ_AP019860.1|WP_151972354.1|9225590_9226601_-|type-2-isopentenyl-diphosphate-Delta-isomerase
MSNLSNRKQDHIDIVLNEKTEPLQSSFDKYYLPYCALPEIDMAKIDSSAMLLNKKLSFPFIISSMTGGLEKGEQINKNLAIAAQQEKVALGLGSMRVIIRYPEMLKTFQVKQHCPDIPLFANIGIVQLNYGFTAEELKKIVDGVEADALFVHINHLQEAIQPEGDTNFENLIPKLEKVVKELSVPIFAKEVGHGIDFNSAKKLRDIGVKYIDVSGMGGCSWAWIEGYRLTEEANLGHTFRAEGIPTDHALKMCSKLQDVTLIAGGGVRSGLDVAKSMTMGASFATAAKPFLGPALQSSDAVAKVIQQWRKEFIVGLFTCGAANVQEISGMECLKRD

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_AP019860_30	30.1|6234399|56|NZ_AP019860|PILER-CR	6234399-6234454	56	NZ_AP019860.1	6234588-6234643	0	1.0
NZ_AP019860_32	32.2|6585931|36|NZ_AP019860|PILER-CR	6585931-6585966	36	NZ_AP019860.1	6585732-6585767	0	1.0
NZ_AP019860_44	44.1|8656246|24|NZ_AP019860|CRT	8656246-8656269	24	NZ_AP019860.1	8656168-8656191	0	1.0
NZ_AP019860_44	44.2|8656306|18|NZ_AP019860|CRT	8656306-8656323	18	NZ_AP019860.1	8656444-8656461	1	0.944
NZ_AP019860_2	2.1|500766|28|NZ_AP019860|CRISPRCasFinder	500766-500793	28	NZ_AP019860.1	501113-501140	2	0.929
NZ_AP019860_29	29.1|6216319|58|NZ_AP019860|CRISPRCasFinder	6216319-6216376	58	NZ_AP019860.1	6217306-6217363	2	0.966
NZ_AP019860_30	30.2|6234505|66|NZ_AP019860|PILER-CR	6234505-6234570	66	NZ_AP019860.1	6234283-6234348	6	0.909

1. spacer 30.1|6234399|56|NZ_AP019860|PILER-CR matches to position: 6234588-6234643, mismatch: 0, identity: 1.0

ctacagattgtttcacgtatacatcctgatcttttagagcaagaataagagctggc	CRISPR spacer
ctacagattgtttcacgtatacatcctgatcttttagagcaagaataagagctggc	Protospacer
********************************************************

2. spacer 32.2|6585931|36|NZ_AP019860|PILER-CR matches to position: 6585732-6585767, mismatch: 0, identity: 1.0

gtgccagctctcattcttgctctagaagacgagaat	CRISPR spacer
gtgccagctctcattcttgctctagaagacgagaat	Protospacer
************************************

3. spacer 44.1|8656246|24|NZ_AP019860|CRT matches to position: 8656168-8656191, mismatch: 0, identity: 1.0

tgagaaagaaaatgcacaaccact	CRISPR spacer
tgagaaagaaaatgcacaaccact	Protospacer
************************

4. spacer 44.2|8656306|18|NZ_AP019860|CRT matches to position: 8656444-8656461, mismatch: 1, identity: 0.944

agtgtcagactcaccact	CRISPR spacer
agtgccagactcaccact	Protospacer
****.*************

5. spacer 2.1|500766|28|NZ_AP019860|CRISPRCasFinder matches to position: 501113-501140, mismatch: 2, identity: 0.929

gcaattatgaagatttgcgattcgggat	CRISPR spacer
gcaattgtgaggatttgcgattcgggat	Protospacer
******.***.*****************

6. spacer 29.1|6216319|58|NZ_AP019860|CRISPRCasFinder matches to position: 6217306-6217363, mismatch: 2, identity: 0.966

gcagagataagcgggggaacagctttttctcctatctttgccagtgcttctacagcat	CRISPR spacer
gcagaaataagcgggggaacagctttttctcccatctttgccagtgcttctacagcat	Protospacer
*****.**************************.*************************

7. spacer 30.2|6234505|66|NZ_AP019860|PILER-CR matches to position: 6234283-6234348, mismatch: 6, identity: 0.909

ttttcccaatgcatttactgtatacctcctcactaagtcgtttttgtctttcaatagaaa	CRISPR spacer
ttttcccaatgcatttactgtatacctcctcactaagtcgtttttgtctttcaatagaaa	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_AP019860_44	44.1|8656246|24|NZ_AP019860|CRT	8656246-8656269	24	MN657148	Polaromonas sp. strain ANT_J29B plasmid pA29BJ2, complete sequence	88504-88527	3	0.875
NZ_AP019860_3	3.1|779210|27|NZ_AP019860|CRISPRCasFinder	779210-779236	27	NC_007387	Spiroplasma citri pSci1 plasmid	36-62	4	0.852
NZ_AP019860_3	3.1|779210|27|NZ_AP019860|CRISPRCasFinder	779210-779236	27	NZ_CP031090	Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence	10688-10714	4	0.852
NZ_AP019860_3	3.1|779210|27|NZ_AP019860|CRISPRCasFinder	779210-779236	27	NZ_CP043832	Bacillus sp. BS98 plasmid unnamed2	200461-200487	4	0.852
NZ_AP019860_3	3.9|779831|27|NZ_AP019860|CRISPRCasFinder	779831-779857	27	MN693300	Marine virus AFVG_25M71, complete genome	20175-20201	4	0.852
NZ_AP019860_3	3.9|779831|27|NZ_AP019860|CRISPRCasFinder	779831-779857	27	MN693380	Marine virus AFVG_25M72, complete genome	20154-20180	4	0.852
NZ_AP019860_3	3.1|779210|27|NZ_AP019860|CRISPRCasFinder	779210-779236	27	NZ_CP009967	Bacillus cereus E33L plasmid pBCO_1, complete sequence	159414-159440	5	0.815
NZ_AP019860_3	3.1|779210|27|NZ_AP019860|CRISPRCasFinder	779210-779236	27	NC_007103	Bacillus cereus E33L plasmid pE33L466, complete sequence	162763-162789	5	0.815
NZ_AP019860_3	3.4|779486|27|NZ_AP019860|CRISPRCasFinder	779486-779512	27	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	812595-812621	5	0.815
NZ_AP019860_3	3.6|779624|27|NZ_AP019860|CRISPRCasFinder	779624-779650	27	NZ_LR214986	Mycoplasma cynos strain NCTC10142 plasmid 13	812595-812621	5	0.815
NZ_AP019860_33	33.1|6804422|29|NZ_AP019860|CRISPRCasFinder	6804422-6804450	29	MN693675	Marine virus AFVG_250M630, complete genome	17182-17210	5	0.828
NZ_AP019860_33	33.1|6804422|29|NZ_AP019860|CRISPRCasFinder	6804422-6804450	29	MN693578	Marine virus AFVG_25M520, complete genome	17418-17446	5	0.828
NZ_AP019860_3	3.1|779210|27|NZ_AP019860|CRISPRCasFinder	779210-779236	27	MN694566	Marine virus AFVG_250M779, complete genome	12532-12558	6	0.778
NZ_AP019860_3	3.4|779486|27|NZ_AP019860|CRISPRCasFinder	779486-779512	27	LR588166	Pseudomonas phage vB_PaeM_MIJ3	128538-128564	6	0.778
NZ_AP019860_3	3.4|779486|27|NZ_AP019860|CRISPRCasFinder	779486-779512	27	MH121069	Pseudomonas phage vB_PaeM_PA5oct, complete genome	245073-245099	6	0.778
NZ_AP019860_3	3.6|779624|27|NZ_AP019860|CRISPRCasFinder	779624-779650	27	LR588166	Pseudomonas phage vB_PaeM_MIJ3	128538-128564	6	0.778
NZ_AP019860_3	3.6|779624|27|NZ_AP019860|CRISPRCasFinder	779624-779650	27	MH121069	Pseudomonas phage vB_PaeM_PA5oct, complete genome	245073-245099	6	0.778
NZ_AP019860_3	3.9|779831|27|NZ_AP019860|CRISPRCasFinder	779831-779857	27	MN693379	Marine virus AFVG_25M207, complete genome	15840-15866	6	0.778
NZ_AP019860_3	3.9|779831|27|NZ_AP019860|CRISPRCasFinder	779831-779857	27	HQ331142	Salmonella phage S16, complete genome	626-652	6	0.778
NZ_AP019860_3	3.9|779831|27|NZ_AP019860|CRISPRCasFinder	779831-779857	27	KJ000058	Salmonella phage STP4-a, complete genome	617-643	6	0.778
NZ_AP019860_17	17.1|3891039|32|NZ_AP019860|CRISPRCasFinder	3891039-3891070	32	AP013718	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S42-C114, *** SEQUENCING IN PROGRESS ***	10959-10990	8	0.75
NZ_AP019860_41	41.1|8095674|32|NZ_AP019860|CRISPRCasFinder	8095674-8095705	32	NZ_CP050185	Bacillus thuringiensis strain HER1410 plasmid pLUSID2, complete sequence	73639-73670	8	0.75
NZ_AP019860_13	13.1|2797530|31|NZ_AP019860|CRISPRCasFinder	2797530-2797560	31	NC_047925	Lactobacillus phage Nyseid, complete genome	23624-23654	9	0.71
NZ_AP019860_13	13.1|2797530|31|NZ_AP019860|CRISPRCasFinder	2797530-2797560	31	KU052488	Lactobacillus phage SA-C12, complete genome	59256-59286	9	0.71
NZ_AP019860_22	22.1|4853274|32|NZ_AP019860|CRISPRCasFinder	4853274-4853305	32	NZ_CP021155	Photobacterium damselae subsp. damselae strain KC-Na-1 plasmid pPDD-Na-1-3, complete sequence	19423-19454	10	0.688
NZ_AP019860_22	22.1|4853274|32|NZ_AP019860|CRISPRCasFinder	4853274-4853305	32	NZ_CP035461	Photobacterium damselae subsp. damselae strain KC-Na-NB1 plasmid pFPPDNB1-3, complete sequence	66807-66838	10	0.688

1. spacer 44.1|8656246|24|NZ_AP019860|CRT matches to MN657148 (Polaromonas sp. strain ANT_J29B plasmid pA29BJ2, complete sequence) position: , mismatch: 3, identity: 0.875

tgagaaagaaaatgcacaaccact	CRISPR spacer
ggagaaagcaaatgcacaacaact	Protospacer
 ******* *********** ***

2. spacer 3.1|779210|27|NZ_AP019860|CRISPRCasFinder matches to NC_007387 (Spiroplasma citri pSci1 plasmid) position: , mismatch: 4, identity: 0.852

tcatttttatgtaaataaagttctttg	CRISPR spacer
ttatttttatgaaaataaagttattta	Protospacer
*.********* ********** ***.

3. spacer 3.1|779210|27|NZ_AP019860|CRISPRCasFinder matches to NZ_CP031090 (Spiroplasma phoeniceum P40 plasmid pSPh387, complete sequence) position: , mismatch: 4, identity: 0.852

tcatttttatgtaaataaagttctttg	CRISPR spacer
ttatttttatgaaaataaagttattta	Protospacer
*.********* ********** ***.

4. spacer 3.1|779210|27|NZ_AP019860|CRISPRCasFinder matches to NZ_CP043832 (Bacillus sp. BS98 plasmid unnamed2) position: , mismatch: 4, identity: 0.852

tcatttttatgtaaataaagttctttg	CRISPR spacer
tcatttttaagtaaataaagtagttag	Protospacer
********* ***********  ** *

5. spacer 3.9|779831|27|NZ_AP019860|CRISPRCasFinder matches to MN693300 (Marine virus AFVG_25M71, complete genome) position: , mismatch: 4, identity: 0.852

tggtttaattgcaaatgaagttcctgg	CRISPR spacer
ttgtttaattgtaaatgcagttcctga	Protospacer
* *********.***** ********.

6. spacer 3.9|779831|27|NZ_AP019860|CRISPRCasFinder matches to MN693380 (Marine virus AFVG_25M72, complete genome) position: , mismatch: 4, identity: 0.852

tggtttaattgcaaatgaagttcctgg	CRISPR spacer
ttgtttaattgtaaatgcagttcctga	Protospacer
* *********.***** ********.

7. spacer 3.1|779210|27|NZ_AP019860|CRISPRCasFinder matches to NZ_CP009967 (Bacillus cereus E33L plasmid pBCO_1, complete sequence) position: , mismatch: 5, identity: 0.815

tcatttttatgtaaataaagttctttg	CRISPR spacer
gtagttttatgtaactaaagttctttt	Protospacer
 .* ********** *********** 

8. spacer 3.1|779210|27|NZ_AP019860|CRISPRCasFinder matches to NC_007103 (Bacillus cereus E33L plasmid pE33L466, complete sequence) position: , mismatch: 5, identity: 0.815

tcatttttatgtaaataaagttctttg	CRISPR spacer
gtagttttatgtaactaaagttctttt	Protospacer
 .* ********** *********** 

9. spacer 3.4|779486|27|NZ_AP019860|CRISPRCasFinder matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 5, identity: 0.815

tgatttttggacaaatttaggcgcgta	CRISPR spacer
tgatttttggacaaagttaggagaaaa	Protospacer
*************** ***** * . *

10. spacer 3.6|779624|27|NZ_AP019860|CRISPRCasFinder matches to NZ_LR214986 (Mycoplasma cynos strain NCTC10142 plasmid 13) position: , mismatch: 5, identity: 0.815

tgatttttggacaaatttaggcgcgta	CRISPR spacer
tgatttttggacaaagttaggagaaaa	Protospacer
*************** ***** * . *

11. spacer 33.1|6804422|29|NZ_AP019860|CRISPRCasFinder matches to MN693675 (Marine virus AFVG_250M630, complete genome) position: , mismatch: 5, identity: 0.828

ccaagcaacaaataacgctcaatatcaac--	CRISPR spacer
aaaagcaaaaaataacgctca--atcaacaa	Protospacer
  ****** ************  ******  

12. spacer 33.1|6804422|29|NZ_AP019860|CRISPRCasFinder matches to MN693578 (Marine virus AFVG_25M520, complete genome) position: , mismatch: 5, identity: 0.828

ccaagcaacaaataacgctcaatatcaac--	CRISPR spacer
aaaagcaaaaaataacgctca--atcaacaa	Protospacer
  ****** ************  ******  

13. spacer 3.1|779210|27|NZ_AP019860|CRISPRCasFinder matches to MN694566 (Marine virus AFVG_250M779, complete genome) position: , mismatch: 6, identity: 0.778

tcatttttatgtaaataaagttctttg	CRISPR spacer
aattttttttgtaaataaagttcatta	Protospacer
   ***** ************** **.

14. spacer 3.4|779486|27|NZ_AP019860|CRISPRCasFinder matches to LR588166 (Pseudomonas phage vB_PaeM_MIJ3) position: , mismatch: 6, identity: 0.778

tgatttttggacaaatttaggcgcgta	CRISPR spacer
gaatgtttggacaaatttaggcgtatc	Protospacer
 .** ******************..* 

15. spacer 3.4|779486|27|NZ_AP019860|CRISPRCasFinder matches to MH121069 (Pseudomonas phage vB_PaeM_PA5oct, complete genome) position: , mismatch: 6, identity: 0.778

tgatttttggacaaatttaggcgcgta	CRISPR spacer
gaatgtttggacaaatttaggcgtatc	Protospacer
 .** ******************..* 

16. spacer 3.6|779624|27|NZ_AP019860|CRISPRCasFinder matches to LR588166 (Pseudomonas phage vB_PaeM_MIJ3) position: , mismatch: 6, identity: 0.778

tgatttttggacaaatttaggcgcgta	CRISPR spacer
gaatgtttggacaaatttaggcgtatc	Protospacer
 .** ******************..* 

17. spacer 3.6|779624|27|NZ_AP019860|CRISPRCasFinder matches to MH121069 (Pseudomonas phage vB_PaeM_PA5oct, complete genome) position: , mismatch: 6, identity: 0.778

tgatttttggacaaatttaggcgcgta	CRISPR spacer
gaatgtttggacaaatttaggcgtatc	Protospacer
 .** ******************..* 

18. spacer 3.9|779831|27|NZ_AP019860|CRISPRCasFinder matches to MN693379 (Marine virus AFVG_25M207, complete genome) position: , mismatch: 6, identity: 0.778

tggtttaattgcaaatgaagttcctgg	CRISPR spacer
tggtttaattgcaaatgaagcaaattt	Protospacer
********************.   *  

19. spacer 3.9|779831|27|NZ_AP019860|CRISPRCasFinder matches to HQ331142 (Salmonella phage S16, complete genome) position: , mismatch: 6, identity: 0.778

tggtttaattgcaaatgaagttcctgg	CRISPR spacer
gtttttaactgcaaatgaagttcgtga	Protospacer
   *****.************** **.

20. spacer 3.9|779831|27|NZ_AP019860|CRISPRCasFinder matches to KJ000058 (Salmonella phage STP4-a, complete genome) position: , mismatch: 6, identity: 0.778

tggtttaattgcaaatgaagttcctgg	CRISPR spacer
gtttttaactgcaaatgaagttcgtga	Protospacer
   *****.************** **.

21. spacer 17.1|3891039|32|NZ_AP019860|CRISPRCasFinder matches to AP013718 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S42-C114, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.75

cttaaataattagcaaataatgccttaagcat-	CRISPR spacer
ttcctataattagcagataatgacttaa-tata	Protospacer
.*.  **********.****** ***** .** 

22. spacer 41.1|8095674|32|NZ_AP019860|CRISPRCasFinder matches to NZ_CP050185 (Bacillus thuringiensis strain HER1410 plasmid pLUSID2, complete sequence) position: , mismatch: 8, identity: 0.75

ttttaagtactcaacatgtaaaatct---tatgta	CRISPR spacer
atgtaaatattcaacatgtaaaatctgtccat---	Protospacer
 * ***.**.****************   .**   

23. spacer 13.1|2797530|31|NZ_AP019860|CRISPRCasFinder matches to NC_047925 (Lactobacillus phage Nyseid, complete genome) position: , mismatch: 9, identity: 0.71

gtggttggtatttgtttggtttagcacttct	CRISPR spacer
ttggttgttatttgttttgtttagttaggat	Protospacer
 ****** ********* ******.     *

24. spacer 13.1|2797530|31|NZ_AP019860|CRISPRCasFinder matches to KU052488 (Lactobacillus phage SA-C12, complete genome) position: , mismatch: 9, identity: 0.71

gtggttggtatttgtttggtttagcacttct	CRISPR spacer
ttggttgttatttgttttgtttagttaggat	Protospacer
 ****** ********* ******.     *

25. spacer 22.1|4853274|32|NZ_AP019860|CRISPRCasFinder matches to NZ_CP021155 (Photobacterium damselae subsp. damselae strain KC-Na-1 plasmid pPDD-Na-1-3, complete sequence) position: , mismatch: 10, identity: 0.688

gaatatcaacacattatttcccttgaacaacg	CRISPR spacer
tgatatccacacattatctcccttgtatttga	Protospacer
 .***** *********.******* *.   .

26. spacer 22.1|4853274|32|NZ_AP019860|CRISPRCasFinder matches to NZ_CP035461 (Photobacterium damselae subsp. damselae strain KC-Na-NB1 plasmid pFPPDNB1-3, complete sequence) position: , mismatch: 10, identity: 0.688

gaatatcaacacattatttcccttgaacaacg	CRISPR spacer
tgatatccacacattatctcccttgtatttga	Protospacer
 .***** *********.******* *.   .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1353778 : 1362375	7	Staphylococcus_phage(50.0%)	NA	NA
DBSCAN-SWA_2	3070990 : 3081778	8	uncultured_virus(50.0%)	NA	NA
DBSCAN-SWA_3	3723830 : 3736625	8	Acinetobacter_phage(14.29%)	NA	NA
DBSCAN-SWA_4	6514664 : 6589538	41	Klosneuvirus(25.0%)	transposase,protease	NA
DBSCAN-SWA_5	8936311 : 8992220	38	Klosneuvirus(16.67%)	tail,plate,tRNA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NZ_AP019860|1353778:1362375|DBSCAN-SWA
TATGCAAGAAACACCTTATTTAGTGGGGATTGATTTAGGGACGACGAATTGTAGTGTCGCATATATTCATCGTTCGCGTAAGCGTTCACAACACAAGATAAAAATATTTGAAATACCACAAATTGTGTCGGCAAATGCTATTGAGGAGCGCAAAACGTTACCTTCTTTTCATTATAGTTTGTCTGAGTTCGATACCTTATCCGTCGCCATGCCTTGGGAAGACAAACCATCGTATATCGTGGGGGAATTTGCCAAGAAACAAAAAATTCCCGACAACATTGTGCATTCTGCAAAGTCATGGTTATGCCATTCACGTGTTGATCGCCGTAGTCCTATTTTACCCTGGGGAACCAAAAGCACACAAAAAATTTCACCAGTGGAAGCGGCGGTGAGATATCTGAAGTTCATACAAGAAGCTTGGAATCACTATGTCGCCAAAGAGTCCCATGAGCATCTACAACAGCAACAGATTGTACTGACGGTACCTGCGGCTTTTGATCAGGATGCGCGAGAACTTACTTTAGAAGCGGCGAATAAAGCGGGATTTAAAAATGTAAACTTACTCGAAGAGCCCATGGCCGCCTTTTATTCATGGATTTATTTTTATCAATTTAAGTGGCCAAAAAAAGTTCAGGATAATATGTTGGCTTTGGTGTGCGACTTAGGAGGCGGAACTACAGACTTTAGTCTTATCGAGTTACAGCGCAACGAAGATAATTTCCAATTTAAAAGAGTGGCCGTTGGTAAGCACCTTCTGTTGGGGGGAGATAATATGGATCTTGCTCTTGCTTACCGACTGGAAAAGAGTAAACTTTCGAGTAATCAGTTTTTAGAACTAGTCTCGGCCGCACGCCATGCAAAAGAGTATCTATGGACAAGCGGTAACGAAGATAAAAACTCGGACATTACGATCATGGGCGGCGGGAGTTCTCTTGTTAAGGGAGCGAAAAAATTCGAGGTAAGTCACGAACTTTTACAAGAAGTTATCGTGGAACAATTTTTCCCGATTTTACCTTGGGAAGCTCCAGGGGAATCGAAACAATCCGGGTTGAAGGATTGGGGACTTCCTTATGAAACAGATCCGCGAATCACAAAGCACCTTTGTGACTTTCTTCATCGACATCTCGAAGAAAACACTAAACCTGATTTGATTTTGTTTAACGGGGGAGTATTGACTCCTAAGGCAATTCGCGACCGAATCGTGTCGCAATTAAAAGAATGGTTTGGTAGCTCTTCATGGAAACCTATTGTTTTAACCAACAACAAGCTCGATTTGGCCGTGGCTATTGGAGCAGCGTATTTTCATCTTGTGCAACGTGGCGAAGGCATTCAAATCGGTGGTGGTATTCCGCGTTCATACTATCTCGAAATAAAACAGCACCAGGGCAAGAAAAAGGGACTGTGTATTTTACCGTTTGCTTCGCGACAACAGCAATTTTTTGAAATCAACCAACATACTTTAGAGGTGATTGCAAAGCAACCAGTGTCTTTTAAAATTTATTCTAGTAACGAGCGCAAGGAGGATGAGTTAGGTCAGGTTGTGGACCTCGAAGAAAACATGGTGTTACTTCCTCCTGTTCAAACAGTTATTAAAGTGGGGAAAACGGCTAAGAAACGCCAAATTCCGGTAAATTTGCAAGCGCAAATGAATGAGATTGGGCTTTTGGAAATTAGGTTGGTGGCCAAAGATTCTGACCGTATTTGGCGCTTACAATTTCAAATGAGCCATGCTCAGGAACCTAAAAAAATAGAAAAACAAGTTAGCAAAAAGAAAATAGTCTTTCCCGAGCAAAAGATACGAGAGGTTATCGAAGGAGTTTTCTGTAAAGATCTAGCACCACGCACCTTGAAAAACGACATTGAAAAAATACTTGGTTGCAAAAAAGACGCCTGGGATTTACAATTAAATCGAAAGATATGGGACATTCTCATTTCTTTTGCTACACAAAAAAATCGCAGCGAAAACCACGAGGAACGCTGGCTACACCTTGTTGGATTCTGTTTGCGTCCAGGAATTGGATTCCCTGGAGATGATTGGCGCATAAAAAAATTACTTCCCATTATACAAAATCGTGTACACTTTACGCGCAACATCCAGAATTGGATGGAATATTGGATTCTACTGAGAAGAATTGCCGCTAGTTTACGAGGAGAGCAGCAGCTTAATTTATTAAAGCTTTTTGCGGAGCATTTGTTAGGGCCATCGACAAAATGGAAGATGAAAAAAACAACACGTAAACATGTAAAACCGGCCGAGAAGGTAGAAATGTGGCGTACTGTGTCTAGTTTCGAAAATTTGCCTGCCAAGGTAAAACAACAGCTTGGAGATGAAATTATACGTTTGTTCTCTAAGGAAAAAAATCTCGATCATTTGTATTGGGCTTTGGGAAGATTGGGAGCGCGTATTCTTTTTTACAATCAAAACCCTTTAGAAAAAGACCAAATTACTCCGTGGATTGAGACTCTTCTCGCTATGGAAAATGATAATTTTCATCGTCTTTCCGCGCTAGCGCAACTTGCGCGAAAATCAGGAGATCGCAGTATTGATATCGACGATGATTTGCGCCAGCGCGTAATAGAAGAATTGCAAAAATACGATGACTCTGCCAAAATAAATGAATTGTGTTCTTCTGTAGAAACGATAACTGTTCTCAATGAAAAGTTACAAAAACATTACTTTGGAGACTCTCTCCCTACAGGTCTTCTCCTAAAATAGGAGTATGTATGGTAAAAGCTATTATTGTTTATATATTTCTCATTATGTTGGCATTGATTTCTTTATTATTTTGGCATATTGTCAAGCGCAATAGATGGGAAACTGAGTTAAAACAAGCGCACAATAAGCTCCAAAAAGCCAATGCAAAATTACAAAGTGAGATAGAACAGCACGAAAAAACTATTCGTGAAAAACACAGAATTCACACGCAGCTTTTGCATACGCAAAAGTTGGAGGCTATTGGCCGTCTTGCCGGGGGAATTTCCCATGATTTTAACAACTTACTTACCGTAATTCTCGGTTATAGTGATTTAATTATGGAAGAGACATCTGACAACGGCGATGTGTATGAGTTGGCCCAAGAAATTAAACAAGTGGCACAACAAGCGACTTCGTTACCAAGGCAACTTCTGGCATTTAGCCGTAAGCAAGTGTTACAGTCTGAAATCGTCAATGTCAACAGTATGTTACAGAAGATGAGCAAGTTTCTAACGCGTATGATTCGTGAAGATATCGAATTTACCATAAATTTTCACTCTGATAATACATACGTAGAGATTGACCCTGGTCAGATTGAGCAAGTTATCATGAATTTGGTTCTCAATGCCTGTGATGCGATACCTAATGGTGGAAAGCTGTCCATTACAACGGAGCATGTACATATTAATCCTCGTGTTTCTGAGTTTATGGTAGATGCCGTTTTTGGTGATTTCGTATGTATTTGTGTTGCCGACAATGGTTGTGGCATCGACAAGGAACACCTTCCATATGTATTTGAACCTTTTTTTACGACAAAACTCAATGAAAATTCTGGGTTAGGACTGTCGGTGGTTTATGGAATTGTTAAACAGCACGATGGATGGATTCACCTAGAAAGTTCGGCAAAGCGTGGAACTTGTATTAAGGTCTTCTTGCCTTTTTGTAAAAACGTTTACTGTCATGAAGAGCAGGACCCGCAAGTATCTGTTGAGCTTTATCAAGGTCAAGGAGAGAAAATTTTATTGGTGGAAGATGACGTACAGGTATGTCGCTTTACAAGTAGAATTTTACAACGCAACGGATATGATGTTCTGAAAGCCCACAGTGCCGAAGAGGCGATAGACATTTTTTTTGAGAAGAATTGTAAGTTTGATTTGATGATAAGCGATGTTATTTTACCGAAAAAGAATGGCTTAGAGTTGGCGGAATATCTTGTTCAAGAAAAAAGTAATCTACCAGTTATTTTGTCGACGGGATATGCGGATCAAAAATTGCCTACGCATTTTACCAGTCAAAATCATTTACGCTTATTGAAAAAACCATACAGTGTCTCCGATTTACTGTATGTGATTCGCCAAACACTCAACCATCAATCCGCATAGTAAAGTGGGAGTAAATTCCCGTGGTTTGAAAATGTTAGACACCTCAGTATCTTGGAAATATTTGTATGTCGCAGTTTATGTTACGTGCTCTTGAACTTGCTGAGAAAGCAAGAGGAAAAACAAGTCCTAACCCAATGGTAGGAGCGGTAATCGTCCGCGATGGTGCCATTGTTGGTGAAGGATTTCATTTGCGTGCAGGAGAGCACCATGCTGAAATTATTGCTTTAGAACAGGCGGGAGAAAATGCCCGCGGAGCAACCTTATACATCAATTTAGAACCTTGCTGTCACTATGGAAAAACGCCTCCATGTACAGATGCTATTATTGCCGCAGGTATTCGCCAAGTTCATATGGCAATTTTAGATCCCAATCCTTTGGTTCAAGGTAAGGGAAAACGTATCCTCGAAGAAGCAGGTATCGAGACATCTGTCGGCTGTTGTGCTCAACAGGCGCTACAACTCAATGAAGTTTTTTGTTATTGGATTGAGCATAAACTTCCATTTGTTATTGCTAAATTTGCGATGAGTCTTGACGGCAAAATTGCTACAAAAACAGGTCATTCTCGATGGATTAGTTCCCAGGAATCGCGTTTGTTTGGCCATAGAATACGCAATGAAATTGATGCAATTATTGTCGGGGCGAATACCGTAAAGAAAGATAACCCGATGCTGACAACGCGTTTAGAGAACACCGAAGTGCAACATCCTATTCGGGTGGTCATTGATTCAAAAGGAGGACTTCCTCACGAGGCAAAAATTTTTAGTGACGGTTTACCTGGACAGACCATTTTGGCAACAACAATCCCGCAGCGTTTTCCAAAAAATGTCGAAGTTATGGTACTACCGCAAAGTGATCAAGGTGTTTGCACAAACGCGTTACTGAAAGAATTGGGAAAAAGAGGGATTACTTCTGTACTTTTGGAAGGGGGCGGAACAATACTCTCTAGTTTTCTCGCCAATAATCATGTAAATAAAATATTAGCATTCATTGCGCCCATGATTATTGGTGGCAAAGAAGCTCCTTCACCTGTGGCAGGAGAAGGAATAAACTACATTGAAGAGGCATTTGTATTGAAAGATTTACAAGTGAGCAGATTAGCAGGAGACATCTTAATTAGTGGCTACTGCAAAAGAGGTGAAAATGTTTAGTGGTATTGTCGAAGAGTTAGGGAAAGTACGCAAAATAGCATCTTCTTCTTGGGAAATAACCGCAAATGTTGTTTTGCAAAATACAAAAATAGGTGATAGCATATCAGTGAATGGTGTCTGTCTGACGGTGACGACGTTTAACGAAGATAGTTTTACTGTTGATGTAACACCTGAAACAACACGACGTAGTAACTTAGAACTTTTACGTGCTGGTAGTGTCGTAAACCTTGAGCGCAGTCTGCGTGTCGGAGATCGCATAGGTGGTCATTTTGTCGAAGGTCATGTCGATTCTACAGCAAAAGTTAGCTTTGTAAAAAAAGAAGGTAATTCTTATGTAGTTACGTTCACCCTTGATGCAAAACTAATGCGTTATATAGTTGAAAAGGGATATGTTGCAATTGATGGGATGAGTCTCACGGTTGTCAATCCTCAAAAAGACTGTTTTAGCGTTGCTTTTATTCCACATACTTTTATGAATACGGTTGCGAAAAATTATTCTTATGGTACAGTTGTTAACATTGAAGTTGACATTCTCGCAAAGTACATAGAAAACTTCACAACTAAACGCACGAACACAACAATAAATAGAGAATTTCTCAATGAAAATGGATTTATGTAAGGATGGTATTATGACATCTGTTGTAAGCGAGCAAAAATTCGAAACTCACACAATTGAAACAGCGATTCATGAAATTCAATGTGGAAAAATGATTATTGTCGTTGATGATGAAGATCGCGAAAACGAGGGGGATTTAGTTATACCAGCAGAAAAAATAACCCCAGATATCGTCAATTTCATGGCAACACACGGACGTGGATTGATATGTATTGCACTTACCAAAGAACGTATCGAGAAACTACGCATCCCGATGATGATTAGTGACAAAGATAACAAGGACAAATTTCGCACAGCATTTACGGTTTCTGTTGATGCAAAAAACGGAACAACCACAGGAATCTCCAGTTTTGACCGAGCGAAAACAATTCACACGTTGATTGATCCACACGCAACAACAGAAGACTTGTTAATGCCTGGACATATGTTTCCATTGCGCGCTCACCGTGAGGGGGTGTTAGCACGTCCTGGGCATACAGAAGCTGCGGTAGATTTTGCTCAACTAGCGGGCATGTATCCTGCTGGGGTAATTTGTGAAATTATGTCTGAAGATGGAACGATGGCGCGTTTACCACAATTGCAAGTATTTGCCCAACAACATGATTTGAAAATTTTCACAATCGCCGAGTTGATCGCATACCGAAGAGAAAGGGAATAACATGGCAAAAATTTTTAGTGGAAAGTTAACTGGACAAGGTTTAAAAATAGCAGTAGTTGTCGCACGATACAATAATTTCATCACCGAAAAACTGCTTTCAGGTGCAAAGGACGCTCTTCATCGCCATGGAGTAGAAGACGAGGCCGTGGATATCGCATGGGTCCCTGGGGCATTCGAAATACCACTTATTGCAAAAAAACTAGCTTGTAGTGGTCGCTACGATGCGGTTGTTTGCCTGGGAGCTCTTATTCGCGGTGCCACTTCACATTTTGACTATGTTGCTGCGGAAGCTGCAAAAGGAGTTGCTGCGGCCTCTTTACATAGCGATACACCTGTTATATTTGGAGTTTTGACAACAGATAGCATCGAACAAGCCATTGAACGTGCCGGAACCAAGGCGGGTAATAAAGGTTTTGAAGCAGCAACTGCCGCAATCGAAATGGCAAATTTAAATAACACTTTATCCGAAAACGTCAACTAAAGACTTTATTAGGGAATATGTCACTTTGGCGCCTAAACGTCCTTTTTTCAAATATCTCAGCTTATTTGTTATTCTATGTGGGGGAGTGTTTTTTTCTGTTAGTAGCTTTCATTTTATGGAAGCTGTGGAATACGAAAACTTACAGCTTGAACTCCAAAAACGCGGTGACTCCTGCATCAATTCATTTAAGCGTGAGATTGTGCGCAATTTAGAAGTGCTGACCGGATTACAGGGATTTTTTTCGGCGTCACCTACGATTTCGCGTGATATGTTTTTTGCTTATACAAACTCTGTCTTAAAAGGACGCCCGAGTGTACAGGCTTTGGAGTGGATTCCCAGAGTAAAAACAGAAGACCGTTTGCGCTATGAACAGCTTGCTCAAAACGAGGGACTGACAAATTTTGTGTTTACTGAAAGAGATAACGGAGTGATGATTCCTGTAAAGAATCGTCAAGTGTATTTTCCGGTATACTACACAGCTCCACTTCAAGAAAACGAATCGGTCTTGGGCTTTGATTTATCATCAGATTCTGTGATAAAAAAAGCGTTACAACAAGCTATTAGCAGCAAAAAGATGACCGGAACCATCCCCATTCTTCTTATTCAAAGCAGAGAAAAACAAAAAGGTTTTATGGTGTTTATTCCTGTGTATGATAAAGTAGAGGGGGATAAAAGCACCCCGCAAATTTTACGCGGTTTTGTTGCGGGGGTTTTTGACATCGAAAAAATTTTTCAGGTGGCGATGAAGCATGCAGGTGGAAACGTTTCGGGTCTTTCATTTGCCATTTTTGACCGAACAAATAACCAGCGAAAATCTCTTTATCAAGATGTCTTTCGTTACGATCGCGTTTGGGCAACACACAAACAAACAATTCTCATTGCGCAACGCAAATGGCAAATGATCGTTTATGTGACAAGCCATTTTAAAACCATGCATCTGAAAAGTAACTCACTCGTCATTATGTCCATTAGTTTGTGCTTCACATTTATCATTTGTTTGTATGTTAAAGTGGTATTGGACAAGCATCAAAAAAACGAGGAAATTGTAAAGCTACGTACGCAAGAGCTTCAAACACGCGAAAATCAATACCAACAGTTAGAAAAAATGGCGAAAAAGATGGAGGAACTTGCACGAACAGATCCTTTGACGAAATTATTCAATCGCCGTTATTTTTTAGAAAAGCTTGAGGAAGAAAAAAATCGTAGTGGACGTTCGAGTAAACCTTTTAGTATCGTGCTTATTGATGTTGACCACTTCAAATCCTTTAACGACTCTTATGGACACAGTTGCGGAGATTTTGTACTACAATCTATTGCGAATATAATGAAAGAGACGATACGCAAACAGGATATTGTTGCACGCTGGGGAGGCGAAGAGTTCATTATAATGCTTCCTGAGACATCGATTACTGGATGTAAAACAGTTGCCGAAAAAATAAAAAATAAAGTAGCCTCGCAAGTATATACTTACCAAAATAAAGAAATGTCCGTCACAATCACCGCAGGGGTAGCAATGCACAATAGTGATAGCGACATCGATGAATGTATCAAGAAAGCCGATGATGCCCTTTACAAAGGTAAGAAACATGGACGCAACGAAGTTGTTATTGCTGACTAG

Protein sequences of DBSCAN-SWA_1

>NZ_AP019860|1353778:1362375|1353778_1356493_+|WP_173013137.1|DBSCAN-SWA
MQETPYLVGIDLGTTNCSVAYIHRSRKRSQHKIKIFEIPQIVSANAIEERKTLPSFHYSLSEFDTLSVAMPWEDKPSYIVGEFAKKQKIPDNIVHSAKSWLCHSRVDRRSPILPWGTKSTQKISPVEAAVRYLKFIQEAWNHYVAKESHEHLQQQQIVLTVPAAFDQDARELTLEAANKAGFKNVNLLEEPMAAFYSWIYFYQFKWPKKVQDNMLALVCDLGGGTTDFSLIELQRNEDNFQFKRVAVGKHLLLGGDNMDLALAYRLEKSKLSSNQFLELVSAARHAKEYLWTSGNEDKNSDITIMGGGSSLVKGAKKFEVSHELLQEVIVEQFFPILPWEAPGESKQSGLKDWGLPYETDPRITKHLCDFLHRHLEENTKPDLILFNGGVLTPKAIRDRIVSQLKEWFGSSSWKPIVLTNNKLDLAVAIGAAYFHLVQRGEGIQIGGGIPRSYYLEIKQHQGKKKGLCILPFASRQQQFFEINQHTLEVIAKQPVSFKIYSSNERKEDELGQVVDLEENMVLLPPVQTVIKVGKTAKKRQIPVNLQAQMNEIGLLEIRLVAKDSDRIWRLQFQMSHAQEPKKIEKQVSKKKIVFPEQKIREVIEGVFCKDLAPRTLKNDIEKILGCKKDAWDLQLNRKIWDILISFATQKNRSENHEERWLHLVGFCLRPGIGFPGDDWRIKKLLPIIQNRVHFTRNIQNWMEYWILLRRIAASLRGEQQLNLLKLFAEHLLGPSTKWKMKKTTRKHVKPAEKVEMWRTVSSFENLPAKVKQQLGDEIIRLFSKEKNLDHLYWALGRLGARILFYNQNPLEKDQITPWIETLLAMENDNFHRLSALAQLARKSGDRSIDIDDDLRQRVIEELQKYDDSAKINELCSSVETITVLNEKLQKHYFGDSLPTGLLLK
>NZ_AP019860|1353778:1362375|1360277_1360757_+|WP_151966841.1|DBSCAN-SWA
MAKIFSGKLTGQGLKIAVVVARYNNFITEKLLSGAKDALHRHGVEDEAVDIAWVPGAFEIPLIAKKLACSGRYDAVVCLGALIRGATSHFDYVAAEAAKGVAAASLHSDTPVIFGVLTTDSIEQAIERAGTKAGNKGFEAATAAIEMANLNNTLSENVN
>NZ_AP019860|1353778:1362375|1356501_1357854_+|WP_151966837.1|DBSCAN-SWA
MVKAIIVYIFLIMLALISLLFWHIVKRNRWETELKQAHNKLQKANAKLQSEIEQHEKTIREKHRIHTQLLHTQKLEAIGRLAGGISHDFNNLLTVILGYSDLIMEETSDNGDVYELAQEIKQVAQQATSLPRQLLAFSRKQVLQSEIVNVNSMLQKMSKFLTRMIREDIEFTINFHSDNTYVEIDPGQIEQVIMNLVLNACDAIPNGGKLSITTEHVHINPRVSEFMVDAVFGDFVCICVADNGCGIDKEHLPYVFEPFFTTKLNENSGLGLSVVYGIVKQHDGWIHLESSAKRGTCIKVFLPFCKNVYCHEEQDPQVSVELYQGQGEKILLVEDDVQVCRFTSRILQRNGYDVLKAHSAEEAIDIFFEKNCKFDLMISDVILPKKNGLELAEYLVQEKSNLPVILSTGYADQKLPTHFTSQNHLRLLKKPYSVSDLLYVIRQTLNHQSA
>NZ_AP019860|1353778:1362375|1360842_1362375_+|WP_151966842.1|DBSCAN-SWA
MFFSVSSFHFMEAVEYENLQLELQKRGDSCINSFKREIVRNLEVLTGLQGFFSASPTISRDMFFAYTNSVLKGRPSVQALEWIPRVKTEDRLRYEQLAQNEGLTNFVFTERDNGVMIPVKNRQVYFPVYYTAPLQENESVLGFDLSSDSVIKKALQQAISSKKMTGTIPILLIQSREKQKGFMVFIPVYDKVEGDKSTPQILRGFVAGVFDIEKIFQVAMKHAGGNVSGLSFAIFDRTNNQRKSLYQDVFRYDRVWATHKQTILIAQRKWQMIVYVTSHFKTMHLKSNSLVIMSISLCFTFIICLYVKVVLDKHQKNEEIVKLRTQELQTRENQYQQLEKMAKKMEELARTDPLTKLFNRRYFLEKLEEEKNRSGRSSKPFSIVLIDVDHFKSFNDSYGHSCGDFVLQSIANIMKETIRKQDIVARWGGEEFIIMLPETSITGCKTVAEKIKNKVASQVYTYQNKEMSVTITAGVAMHNSDSDIDECIKKADDALYKGKKHGRNEVVIAD
>NZ_AP019860|1353778:1362375|1358994_1359621_+|WP_151966839.1|DBSCAN-SWA
MFSGIVEELGKVRKIASSSWEITANVVLQNTKIGDSISVNGVCLTVTTFNEDSFTVDVTPETTRRSNLELLRAGSVVNLERSLRVGDRIGGHFVEGHVDSTAKVSFVKKEGNSYVVTFTLDAKLMRYIVEKGYVAIDGMSLTVVNPQKDCFSVAFIPHTFMNTVAKNYSYGTVVNIEVDILAKYIENFTTKRTNTTINREFLNENGFM
>NZ_AP019860|1353778:1362375|1359631_1360276_+|WP_151966840.1|DBSCAN-SWA
MTSVVSEQKFETHTIETAIHEIQCGKMIIVVDDEDRENEGDLVIPAEKITPDIVNFMATHGRGLICIALTKERIEKLRIPMMISDKDNKDKFRTAFTVSVDAKNGTTTGISSFDRAKTIHTLIDPHATTEDLLMPGHMFPLRAHREGVLARPGHTEAAVDFAQLAGMYPAGVICEIMSEDGTMARLPQLQVFAQQHDLKIFTIAELIAYRRERE
>NZ_AP019860|1353778:1362375|1357919_1359002_+|WP_151966838.1|DBSCAN-SWA
MSQFMLRALELAEKARGKTSPNPMVGAVIVRDGAIVGEGFHLRAGEHHAEIIALEQAGENARGATLYINLEPCCHYGKTPPCTDAIIAAGIRQVHMAILDPNPLVQGKGKRILEEAGIETSVGCCAQQALQLNEVFCYWIEHKLPFVIAKFAMSLDGKIATKTGHSRWISSQESRLFGHRIRNEIDAIIVGANTVKKDNPMLTTRLENTEVQHPIRVVIDSKGGLPHEAKIFSDGLPGQTILATTIPQRFPKNVEVMVLPQSDQGVCTNALLKELGKRGITSVLLEGGGTILSSFLANNHVNKILAFIAPMIIGGKEAPSPVAGEGINYIEEAFVLKDLQVSRLAGDILISGYCKRGENV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_173013137.1|1353778_1356493_+	Hsp70 family protein	A0A1V0SG59	Hokovirus	4.9e-07	23.9
WP_151966837.1|1356501_1357854_+	response regulator	NA	NA	NA	NA
WP_151966838.1|1357919_1359002_+	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A1V0SE20	Indivirus	8.3e-51	33.9
WP_151966839.1|1358994_1359621_+	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	3.8e-32	39.5
WP_151966840.1|1359631_1360276_+	3,4-dihydroxy-2-butanone-4-phosphate synthase	A0A2H4PQS2	Staphylococcus_phage	2.3e-48	52.0
WP_151966841.1|1360277_1360757_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	3.8e-40	57.5
WP_151966842.1|1360842_1362375_+	diguanylate cyclase	A0A127AWB9	Bacillus_phage	4.5e-26	38.4

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>NZ_AP019860|3070990:3081778|DBSCAN-SWA
GCTAAACATCTAACGACTTAAACCACTCACTTGCTTTTTTCCAAAATGACTTTTGTTGAGGATTGCTGTTGCTTTTTGTTTCTAGATTATCAAATTCCTGTAATAAGCGTCGTTGTTCTTTGCTCAATTTCTTGGGAACCTCAACAAGAATGACGATTAACTGATCTCCCTTGCCTCGCCCACGAACATTAGGAAAACCTTTGCCATTTAACTTCAACACATCACCATTTTGCGTACCTGCCGGTATCGTCAGCTTTGTCTTGCCGTAAATAGTGGGAATTTCAATGTTGGCTCCCAATGCAGCCTGAGTAAAAGAAATAGGCAACTGCAGTATGACACTATCACTTTGTCTCTCAAAAAATGGGTGCGGTCGAATATTAATTTCGCAGTACAGGTCCCCTCTTTCACCACCTTGTTCGAGAGCTTCACCTTCTCCCGCAATGCGAATTTGCATACCGTGTTCTACACCAGCGGGAATTTTTATCTCTAGCTCGCGAGCCACAGGAACATTTCCTGATCCGCTACACGTCTTACATTTTTTAGCAATGATACTTCCTTGCCCATTGCAATATGGACAACCGGTACGTAGACTAAAGAAACCTTGTGATTGCTGAATAAATCCTCGCCCTTGACAACGATCGCACACATTTCTTTTCGTTCCAGGTGCACACCCTGAGCCACTACAAGTCTCGCAGCCTTCGCGTCTTTTTATATTAATCGATTTCTCTTGGGTTTCTGCTGGTTCGGCAAAATCCATATCGATCGTGCAGTGTAAGTGATTTCCACGGCGACGTCTTCCACGTCCTCCACCACCCATACCAAACAAATCTTCAAAGATTCCGCCGCCAAAAATATCTCCAAAGGCACTAAAAATGTCTTCGGCGTTACTAAAGCCTCCTTGTCCAGATGTCCCAGCGTGTCCAAAACGATCATAGCGACTTCGCTTTTCTGAATCCGACAAAATTTCGTAGGCTTCTGCAGCTTCTTTGAACATTTTTTCGGCCTCTGCATCACCAGGGTTTTTGTCGGGGTGGTATTTTAAGGCTAGTTTTCGGTACTTTGATTTGATTTCATCGGTAGAGGCATTTCTCTCTACTCCGAGAACTTCGTAATAATCTCTTTTTTCGCTCATAGCTACCTATTTTCATAAAATATTAAACCAAAAATTTATGGGTTTTTTAGGCAAACACGTCGACTCATAGTTTTTTATATGAACCAATGTAGAAAGCAGTGCAAAAACTGTTCGGTCTTTGCACTGCTTTGTCTTAAAATACGAGTGTATCTAAGAAACACTTCCTGAAACTTGGTCATCCTTGCCACCGCAATCGGTAATCATTGCTTCTGTTGTCAACATCATACCAGCAACACTAGCAGCGTTTTGCAAAGCAACACGCACAACTTTTGTCGGATCAATAATTCCTTCGGCTAGCATGTCAACAAATTCACCACTACGAGCGTTGAAACCAATGTTCACTTCTTTTTCTTTTACGTCAGCAACAATAACGGTTCCATCGTATCCAGCATTTGACGCGATTTTTTTAATAGGCGCACTAAGTGCGTTGCGAATGATTTGCACACCAAACTTTTCTTCTGGACATGCTTCTAAATTATCCAAAGCATGCAAAGAACGAATGTAAGCAACACCACCACCAGGAACAATTCCCTCTTCTGCGGCTGCTTTTGTCGCGTGTAGTGCATCTTCAACACGTGCTTTCTTCTCTTTCATTTCTGCTTCGGTTGCTGCCCCAACTTCGACAACAGCAACACCACCAGAAAGTTTGGCTAAACGCTCTTGTAATTTCTCACGATCGTAATCGGAAGAGGTTTTTTCGATTTGGTTTTTGATTTGAGAAATGCGGCTTGCGATATCTTCCTTGTTACCAGATCCTTCCACAACGGTGGTCGCATCCTTCGTAATGGTAATGCGCTTGGCATTCCCCAAGTCTTCTAGCTCTACATTTTCTAATTTCAACCCAAGATCTTCACTAATTACCTTACCTCCGGTAAGTACAGCGATATCTTCCAGCATCGCTTTGCGACGATCTCCAAAGCCAGGAGCTTTTACGGCGCACACATTGAGAACACCGCGAAGTTTGTTTACAATAAGCGCTGCTAATGCCTCACCTTCCACATCTTCTGCGATAATAAAAAGTGGTTTTCCACCACGCGCCGTTTTTTCGAGTACAGGTATTAGCTCTTTTACGTTGGAAATCTTCTTCTCGTATAGCAAGATATGCGCATCTTCAAGGTCTGCGCAAGTATTTTCCACGTCGGTAATGAAGTAAGGAGAGATATATCCCTTATCGAATTGCATACCTTCCACGCAACGCATGGATGTCTCAATTCCCTTTGCTTCTTCAACGGTAATCACACCGTCATTACCAACTTTTTCCATGGCGTCGGCCAATAAACTTCCAATTTCAGCGTCACTATTCGCCGAAATGGTTCCGACTTGGGCAATTTCTTCCTTGCCTTTTACTTCACGTGATAGCTTTTGGATTTCGCTGACAACAGCGTCGACCGCTTTGTCAATACCTCTTTTGATTTTAACGGCATTTACGCCTGTGCTTGCATACTTTAAGCCTTCAGAGTAAATCGCTTGTGTTAAAAGAGTTGCAGTTGTGGTTCCGTCTCCCGCAATATCAGAAGTTTTTGAGGCGACTTCGTTCACCATCTTAGCACCCATATTTTCAAATGGGTCTTCTAGTTCTATTTCCTTAGACACAGTAACACCATCTTTGGTTACCGTTGGACTACCAAAACTTTTTTGAATGACTACATTGCGTCCTGTTGGTCCCATTGTAACTGTCACTGTCTTGGCTAATTTATCTAAACCGTCTTTTAATTTCTTACGCGCATCTTCACTATAAAAAAGCTGCTTAGCTCCCATGAAAATTCTCCTTTTTTATACAAACAAAAGTCGTTGCTTTTGTCTTTAGTGAGCTTTAAACATAACTTTTACGGGAAGCCAAAGCTTCCCAGTCACCTTTACCCAAGTTTCGCTAAAATATCACCTTCTTTTAGTATTTTGTACTCAGAACCACCGTACTTTACTTCTGTTCCAGAGTATTTACCAAAAATAACGCGATCGCCTTCGCTAAGGCTACATGCAACACGCTCACCGTTTGCCAATAGCTTTCCATTTCCTACAGCAACTATTTTTCCACGTTGTGGTTTTTCTTTTGCCGTTTCAGGTAAAACGATTCCACCTTGAGTTTTTGCTTCTGCCGCTTCAATTTCTACAACTACGCGATCATCAATTGGTTGAAGAGCCATTTTTAATCTCCTATCAAAAAACTTATTCCTAAGCTAAAAATATTACATCATGTCGTCGCCATATCCGTCATCATCGTCTTTTGGAGCCTCTGCGATGAGACAACCTGTTGTCAATAACAAAGAAGCAACACTTGCCGCATTTTGTAATGCGCTACGCGTTACTTTTGCAGGATCAATGATTCCTTTTTCGTATAAATCGCCAAAAGAATCTTCGCCAGCATCGTAGCCGTAAAATCCGTCTTTTTTCAAGACTTGTTTTGCAACAACGCCGCCTTCTCCACCAGTGTTTTCAACAATTTGTTTGATAGGCATGCTAAGAGCTGCTTTGATGATACTAACACCGTAGTCTTCATCACCACTCAACTTCATATCGTCAAGTGACTTTGCTGCGCGAATCAAAGCAACACCACCACCAGGAAGTGTCCCCTCTTCGATTGCGGCTCTTGTAGCATGGATAGCATCGTCAATGCGTGCTTTGGCTTCTTTAAGCTCGACCTCTGAAGCAGCCCCAACATTAATTTGTGCAACACCACCGGCTAGTTTAGCCAATCGCTCTTGTAATTTTTCGCGGTCATAATCTGAATCGGTATTTTCGATGTCTTTTTTGATTTTTGCTACGCGCGCTTCAATCTCTTCTTTTTTACCTGCACCTTCAACAATTGTAGTATTGTCAGAGGTAATAGTAACCTTTTTCGCTGTACCAAGTTCAGAAAGGGCAACTTGCTCTAAGTCAACACCTAAGTCTTTAAAAAGTGGCTTACCAGCTGTAAGAATACCCAAGTCTTCCATCATCGCTTTACGACGATCTCCGTAACCAGGAGCTTTTACAGCACAGCACTGAACAACGCCGCGAATTTTATTCACAACGAGAGTCGCTAGGGCTTCGCCATCTACATCTTCGGCAATAATAAGTAGCGATCTTTTTGCTTGTGAAATGGCTTCTAGAAGAGGAACGATTTTTTTAATTGCAGATATTTTTTCTTCACAAATGAGAATATAAGGATTGTCAAGAACAACTTCCATTGCATCTTGATTGGTGACAAAGTGTGGAGAAATGTAGCCACGGTCAAATTGCATACCTTCCACGACTTCAACATCTGTTTCCATTCCCTTACCTTCTTCAACGGTAATAACACCGTCTTTTCCAACTTTTTTCATCGCGTCAGAAATCATGTGCCCTACTTTGGCATCATTGTTGGAAGCAATAGTTGCAATTTGTTCAATTTCTTTGTCATCTTTAACTTCTTGGGCAAGCTTTCCCAACTCTTCGACGACTGCCGCCACTGCTTTGTCAATACCTCGGCTAAGAACCAAGGGGTTTGCACCTGCAGTTACATACTTATAACCTTCGAGGAAAATAGCTTCGGCAAGAACAGTTGCCGTAGTTGTGCCGTCACCAGCAACATCTGAAGTTTTAGATGCTACTTCCTTAACCAATTGTGCACCCATGTTTTCATAGGGATCCTGCAACTCCATTTCTTCCGCAACTGTTACGCCATCTTTGGTAACATTGGGAGCTCCCCATCCCTTATCAATGACAACATTACGTCCTTTTGGACCCAGGGTAACTTTAACAGCACGCGCTAGTTTTGTTACTCCTTCGCGGATTGCAGTGCGTGCTTCTTGATCAAAGGCTAATTGTTTAGCCATAAATCCTTCTCCTTACATTACATATTAACGGCATGTCTGTAAAATTTGGTATCTTGCATAAAACAATATTGCTGTAAAGATACCCATAATTTCGTTTTTCTCTATCCTTGCAAAATGTGTACCTAAATATGCAGAAAATATATAAAGCTAGAAAGATGAGCTATTTAGGAGGGAATTTTTTTTGTGTAATATACAGAGATTTTATTTTTTTGCCAGTATGTCATAGTGGCAAACAACCGATACGACATTTTGACATTGGATTGAGGGTGTGGGAGTTGTGCATGGTAGATGCTTAAAATCGTGACCATAGTCGTAATCACGATTACGGTGACGACTACGGCTACGATTACGGTCACGGTGACGATTACGGTTGCGATTGTTTAATTGTTCAAACCATCGCCAAGTAAACCTGTATATGCTTCACCTAAGTCGATAAGCGGTTTATTCGCGGGTGTTAGAAATATTTCGCGAAATACGCGTTCATTCATATAGCCGAAACCTTTTTGCGCTTCGCCATCGCAAAACCATTGATGAATTTTGGCGTGAAATTCATATTCATTGCGCATGGTATCTTCGGCCAATGATTTTTCGAAACTGCGGATTAAGCGAGCAACAGGGCTTTCGACAAGTGCTTTCGAAGCGGTAATTTGAATAGGATTTTGCCACTCAATGACACTACGACTACCGCGATCCAATTTTGCGTCACGGTAATGCAAACGCGCTATTTGTTGCCATACATTTTGCGATGTTTTTTCCCGCAAGGTAGTAATTTTGTGTACTTGCGCCGACCTTTTGCGTACTTGAACCGATCGTATAACGGGAAGTTCTATACCGCGTTTACTTTTGGTTCTTATTGCCGCACGCACCGCCAAAGATTCGCGCGATGGTTTTAAGTTAACGTTTGCGAAAATACCGAGCGTGCGTAAATCTTTACTCCATGACTTGCGAATATTTTTTAAGCGCACTTTGTGGTATGTTTCTATGATTATTTCGCGTTTAAAGTCACTAACGTTCTGTAGTTGAGACCACAAACGCAAGCTCCCGGAAATCACTCTTTGAAAAGCATTTGCACCGTATATACCAGGAACTACATCTAGTAAATTTCCGTGATGATCCATCACATAGTGTGCCGCATTACCCGTGATCGTTCTCTTAACAACACGACCATCACCAAAATCTATAGTTACCACAGGTACGGGGCGTTCTGACTGCCAACACAGTACAAAATTACGGCGTAAATATGACGACAGCTGATTATTCGCGTACAACACGGTACGCATAAAACGTCCATTCGCTCAACAAAACTCTTCGTCTAGTCGCCCCAAAAGTCTTAAAAGCAACAACGGTTTGTTTTGTTGCGCGGCAACTTTTTTTGCCGTATCTATGTCCGTATACCAATACAAACCGGAAAATACCGCGTGTTTTTGTCCCGCCACTCGATCAATAATATCAAAAATTTGCTGTTGTTTTTGTGTTCGTAACACAAGCGGCAACTCTTGGTACTTTTGTAACAATAACTGCAAACCATCGTTTCCCATACTGCGTAATTCAAGAATAGCACTTTCATTATTTTGGAAAGCCAGAGTGCCCAGATTTCTCTCTGCGAACAACAATGAATGTAGCAAAATCATCATGATTGTTATATTGCGCATGTTTTTTCCTTTCATAGTTGTGATATTTGTTATACTCTCATCCTACCACAACTACGCCATTTACAATGTAACATGTTTGTAACAACTACTTACTATGGTTTTTGTCGTTATAGCTAAAAGAGTTGCAATCATTTTTATATTACAGTATAGTAGTAAAAAGGTCATCTTATAGTTGCTTACATATCAAAATTTATCCGTTCAAACTTTTTCGGTGGTCAGCATAAATTACTCTATGCGACGACCAAATCTATTTGAACGAAAAAATTTATTTGTATTACCCTTCTAACTCATTCTTTCGGGGAAACAGTGGAATTCGATCAAAAGACCAACAAAGTTCTCGAAACTTTGAAAAAGCATGCGAAAAAAACCCAGAAAAGACTCCAAGAGACACCCCTAAATCCCATAGCTGTTGACGGTGAACAACCCATATCTGGCTACTGTATCATCGACAAAGTGGGAAGTGGAGGAATGGGGACGGTGTTTAAAGCGCAAAATGTCGATACCGGAGAGCTTGTGGCCATCAAAATGCTCTATCCCGGACATAACAACGACCCAACCATCTTACAACAGTTTATTAACGAAGGAATGATGTTAATAAACCTAAAGCACCCGAACATTCTCAAAGGCTTAGACTTTGGAATATCGAAAGGTTTTTACTTTCTCGCCATCGAACTCGTTGAAGGAGAAAGCCTTATTTCGTTTATAGAAAAAGGCTTTTCATTTACCGAAGAACATGCCTTACGCGTCGCTTTACAAGTCGCACGTGCCCTGGTATATTTGGAAAAGAGAGACATCGTGCACCGCGACATAAAACCTGCCAACATACTGCTTTTGGGTGAAAAGGTAAAGTTATGTGATTTGGCCCTGGCCGTAGAGACAAAAAATCTCGAAGAAACAGAGTCGACCTGCGGAACCGTAGAGTATATTTCTCCAGAACAAGCCCAAGGGGAAAAAACGTTGGATAGTCGCAGTGATGTCTATTCTTTGGGAATCACTTGTATTCACATGATTTCTGGTAAACTTCCCTTTGAAGGAGATAGCGGTGAAGAAGTTATGCGCCGTCATATCTATGAGCCGATAAACCTAAACGCTTTAGGCTCTTTTTCACCGGAGGTACGCAAATTGTTATTTGGTATGACAGAAAAAAAGCAACAAGATCGCCTTACCGCTACTAAAGTAAAAGAAGAAATAAAAACGATTCTACGCAAAAGAAAATAAGGCGCTAATGCGCATAGGTACCCAGGACGTAGAGAATTCTCTGCGCCTCAATCTAGAGAGGTAACGTTTTGTCTGATAAACATCTGATGGGTCTAACCGACGCTGAAGTTATCGAAAGCAGAAAAAAACACGGTGCAAATGTACTCACCCCACCACCGAGAGATCCATGGTGGAAATTATTTTTAGAAAAATTCGAAGACCCAGTTATTCGTATTCTCATTATAGCAGCAGTTCTTTCCATCGCTATTGGCGCTATACACAACGATTACACTGAAGGCATTGCCATTGTCGTTGCTATTATTTTGGCCACAGGTATTGCGTTTTTTAACGAATACAAAGCCAATGCCGAATTTGACATACTCAACCAAGTGAACAATGAAATTCCGATAGAGGTTATCCGCAACGGCAAATTTATGTCCATTCCCATGCATGAGATTGTCGTTGATGATATCTTACTCGTAGGCACCGGACAAGAAGTTCCCGCAGACAGCGAGGTGATGAAAAGTGTCAATCTGCAAGTTTCTCAAGCCAAACTAACAGGGGAATCACATCCGATCAATAAGTGTATCCGTGAAAATAGCAAAGTGACAGAACCTTATCCTGACTACATGTTATACAAGGGAACGGTTGTTGTCGATGGGCATGCTACTTTAAGAGTAGCTTCGGTAGGGGACCACACCGAGATAGGAAAAACGGCTCGCGACGCAGCGGTATTATCGGGAAATACAACACCACTGAACAAACAACTAGCAAAACTCAGTCGCCTTATCGAAGTGGTTGCGTTCACGGTTGCCACCGCTATTTTTATTGCACTTGTTGTACAAGGAATGGGCAATGGCACTCTGGTTTTGACACAAGCGCAATGGATGTTCACCGGAATATCGATATTTGCCATCTATATTTCCCTCACCATGATGTGGGGACCTGTTCTTTTTGACGCTTTTGAAATTTTCAAAATACCCATTTCACCGCCTAAATGGTTAGAAAAGGGTGGTTTTGTTCCATGGATGACCACTATTTTCGTCGCAGGAGCGATATGGGGAATTGGAATTTACCTTTTCACGCAAAATGGCTACATCTCCACTGTGCCTCAGGAATGGATCACTGAAAAAATATTACTGGAATTTCTGCAATACTTTATGATTGCTGTAACCATTATTGTTGTTGCTGTACCAGAAGGGCTAGCACTTAGCGTGACATTATGTCTAGCGTACAGTATGCGCCGCCTCATCGCCAACAACAACCTAGTGCGAAAAATGCATGCCTGTGAGACAATCGGTGCCGCTACGGTAATTTGTTCTGATAAAACCGGTACCCTCACCCAAAACAACATGCATGTTACCGAATTTGAAATTCCCTACAAATCCGACAAAAAATTACAAAATGACGAATGGATCGTACGCTCTATCGCACTCAACAGTACAGCAAACCTTGATTTCTCTCACTCGCAAACTCATCCACAAGTTCTTGGTAATCCGACAGAGGGAGCGCTGCTTCTGTGGTTGCACAAAAACAATGTTGATTATCTACCACTGCGCAAGACGCACGAAAGCCTAAAGGAATGGGCATTCAACACCGAACGTAAGTACATGGCAACAGTGGCTAAATTAAAAGATGTCGAAAACCCTGTACTATTCGTCAAGGGTGCCCCAGAAATTGTGTTACAGAAATGTACATTGGTACAAACCAATGAAAAGCTAAAATCTGTCACCTCCATGGAAAAAGAAATCAACGAACAGCTTGTCGCTTGTCAGGACAAAGGGATGCGTACCATTGGATTTGCTTACAAAGAAATTCAGAACTATACAGACGATATTAACATCGATAAAATAGTCAACGGCATGAACTGGTTGGGATTCACCGCAATTAGTGACCCCATTCGCAGTGATGTTCCCGAAGCCATATCTTCATGTATGCAGGCGGGTGTCGATATAAAAATCGTAACCGGAGACAACGAAAAAACGGCGCGCGAAATTGCCAAACAAATAAATCTATGGCAAGATGAAGATAATGAAAAGCAGAATGTGTTAGTGAGCGGCCAAGAATTTGAAGCCTGGGATGATGACAAGGTAAAAGAAAACTCAAAAGGTATCAAAGTACTATATCGTGCACGCCCAGCAAACAAATTGCGTTTGGTAAAAAGTTTACAGGAACAAAACGAAGTTGTTGCGGTAACAGGTGATGGTGTCAATGATGCCCCAGCACTCAATCATGCAGATGTAGGTTTGGCAATGGGTAAATGCGGGACGTCGATTGCCAAAGAAGCCAGTGACATTGTCCTTTTAGATGACTCATTTACCAGCATCACCAAAGCAATTTTGTGGGGGCGCTCTTTATTTCAAAATATACAACGCTTTTTGATTTTCCAACTCACCATCAACGTTGCGGCACTTGGAATAGCACTTATTGGTCCATTTGTCGGTACACAGTTTCCACTAACAGTAATGCAAATGCTGTGGGTAAACCTGATCATGGACACGTTCGCGGCTCTCGCTCTAGCCACAGAACCACCAAACTCAAAACTGATGAAGCGATCTCCACGTCATCCCGATGATTTCATCATCAATAAAGTAATGACTTGGCTCATTCTAGGTTGGGGATTCATTTTTATATGTGTGATGTTAGGCTTTATGCTATTCTACTTAAAAGGTGTGGGAACCCAGGGAATTCCATGGGAAGATCAACCATTTGAGTACAAGTATCGCCTGACCATATTTTTCAACACCTTCATCTTTTTACAACTGTGGAATATGCTCAATGCCAAAGCGTTTGGTACGGGAAAAAGTGTTTTTAGCACCTTGTTCAAAAACAAAGCCTTCTTGGCAGTGACAACAATTATTGTCGTTGGTCAGCTGCTTATGGTTCAATTTGGAGGCACATTATTCCGCACGATTCCTCTAGCAGCCAATGACTGGCTAAAAATTATTGGCTATACATCTGCGGTACTGTGGATTGGTGAGATATTGCGTCTCATGTTTGGGCACAAATACTAA

Protein sequences of DBSCAN-SWA_2

>NZ_AP019860|3070990:3081778|3070990_3072121_-|WP_151968039.1|DBSCAN-SWA
MSEKRDYYEVLGVERNASTDEIKSKYRKLALKYHPDKNPGDAEAEKMFKEAAEAYEILSDSEKRSRYDRFGHAGTSGQGGFSNAEDIFSAFGDIFGGGIFEDLFGMGGGGRGRRRRGNHLHCTIDMDFAEPAETQEKSINIKRREGCETCSGSGCAPGTKRNVCDRCQGRGFIQQSQGFFSLRTGCPYCNGQGSIIAKKCKTCSGSGNVPVARELEIKIPAGVEHGMQIRIAGEGEALEQGGERGDLYCEINIRPHPFFERQSDSVILQLPISFTQAALGANIEIPTIYGKTKLTIPAGTQNGDVLKLNGKGFPNVRGRGKGDQLIVILVEVPKKLSKEQRRLLQEFDNLETKSNSNPQQKSFWKKASEWFKSLDV
>NZ_AP019860|3070990:3081778|3073977_3074265_-|WP_151968041.1|DBSCAN-SWA
MALQPIDDRVVVEIEAAEAKTQGGIVLPETAKEKPQRGKIVAVGNGKLLANGERVACSLSEGDRVIFGKYSGTEVKYGGSEYKILKEGDILAKLG
>NZ_AP019860|3070990:3081778|3072271_3073879_-|WP_151968040.1|DBSCAN-SWA
MGAKQLFYSEDARKKLKDGLDKLAKTVTVTMGPTGRNVVIQKSFGSPTVTKDGVTVSKEIELEDPFENMGAKMVNEVASKTSDIAGDGTTTATLLTQAIYSEGLKYASTGVNAVKIKRGIDKAVDAVVSEIQKLSREVKGKEEIAQVGTISANSDAEIGSLLADAMEKVGNDGVITVEEAKGIETSMRCVEGMQFDKGYISPYFITDVENTCADLEDAHILLYEKKISNVKELIPVLEKTARGGKPLFIIAEDVEGEALAALIVNKLRGVLNVCAVKAPGFGDRRKAMLEDIAVLTGGKVISEDLGLKLENVELEDLGNAKRITITKDATTVVEGSGNKEDIASRISQIKNQIEKTSSDYDREKLQERLAKLSGGVAVVEVGAATEAEMKEKKARVEDALHATKAAAEEGIVPGGGVAYIRSLHALDNLEACPEEKFGVQIIRNALSAPIKKIASNAGYDGTVIVADVKEKEVNIGFNARSGEFVDMLAEGIIDPTKVVRVALQNAASVAGMMLTTEAMITDCGGKDDQVSGSVS
>NZ_AP019860|3070990:3081778|3074307_3075915_-|WP_151968042.1|DBSCAN-SWA
MAKQLAFDQEARTAIREGVTKLARAVKVTLGPKGRNVVIDKGWGAPNVTKDGVTVAEEMELQDPYENMGAQLVKEVASKTSDVAGDGTTTATVLAEAIFLEGYKYVTAGANPLVLSRGIDKAVAAVVEELGKLAQEVKDDKEIEQIATIASNNDAKVGHMISDAMKKVGKDGVITVEEGKGMETDVEVVEGMQFDRGYISPHFVTNQDAMEVVLDNPYILICEEKISAIKKIVPLLEAISQAKRSLLIIAEDVDGEALATLVVNKIRGVVQCCAVKAPGYGDRRKAMMEDLGILTAGKPLFKDLGVDLEQVALSELGTAKKVTITSDNTTIVEGAGKKEEIEARVAKIKKDIENTDSDYDREKLQERLAKLAGGVAQINVGAASEVELKEAKARIDDAIHATRAAIEEGTLPGGGVALIRAAKSLDDMKLSGDEDYGVSIIKAALSMPIKQIVENTGGEGGVVAKQVLKKDGFYGYDAGEDSFGDLYEKGIIDPAKVTRSALQNAASVASLLLTTGCLIAEAPKDDDDGYGDDMM
>NZ_AP019860|3070990:3081778|3077210_3077567_-|WP_151968044.1|DBSCAN-SWA
MRNITIMMILLHSLLFAERNLGTLAFQNNESAILELRSMGNDGLQLLLQKYQELPLVLRTQKQQQIFDIIDRVAGQKHAVFSGLYWYTDIDTAKKVAAQQNKPLLLLRLLGRLDEEFC
>NZ_AP019860|3070990:3081778|3078871_3081778_+|WP_152021992.1|DBSCAN-SWA
MGLTDAEVIESRKKHGANVLTPPPRDPWWKLFLEKFEDPVIRILIIAAVLSIAIGAIHNDYTEGIAIVVAIILATGIAFFNEYKANAEFDILNQVNNEIPIEVIRNGKFMSIPMHEIVVDDILLVGTGQEVPADSEVMKSVNLQVSQAKLTGESHPINKCIRENSKVTEPYPDYMLYKGTVVVDGHATLRVASVGDHTEIGKTARDAAVLSGNTTPLNKQLAKLSRLIEVVAFTVATAIFIALVVQGMGNGTLVLTQAQWMFTGISIFAIYISLTMMWGPVLFDAFEIFKIPISPPKWLEKGGFVPWMTTIFVAGAIWGIGIYLFTQNGYISTVPQEWITEKILLEFLQYFMIAVTIIVVAVPEGLALSVTLCLAYSMRRLIANNNLVRKMHACETIGAATVICSDKTGTLTQNNMHVTEFEIPYKSDKKLQNDEWIVRSIALNSTANLDFSHSQTHPQVLGNPTEGALLLWLHKNNVDYLPLRKTHESLKEWAFNTERKYMATVAKLKDVENPVLFVKGAPEIVLQKCTLVQTNEKLKSVTSMEKEINEQLVACQDKGMRTIGFAYKEIQNYTDDINIDKIVNGMNWLGFTAISDPIRSDVPEAISSCMQAGVDIKIVTGDNEKTAREIAKQINLWQDEDNEKQNVLVSGQEFEAWDDDKVKENSKGIKVLYRARPANKLRLVKSLQEQNEVVAVTGDGVNDAPALNHADVGLAMGKCGTSIAKEASDIVLLDDSFTSITKAILWGRSLFQNIQRFLIFQLTINVAALGIALIGPFVGTQFPLTVMQMLWVNLIMDTFAALALATEPPNSKLMKRSPRHPDDFIINKVMTWLILGWGFIFICVMLGFMLFYLKGVGTQGIPWEDQPFEYKYRLTIFFNTFIFLQLWNMLNAKAFGTGKSVFSTLFKNKAFLAVTTIIVVGQLLMVQFGGTLFRTIPLAANDWLKIIGYTSAVLWIGEILRLMFGHKY
>NZ_AP019860|3070990:3081778|3076295_3077195_-|WP_151968043.1|DBSCAN-SWA
MRTVLYANNQLSSYLRRNFVLCWQSERPVPVVTIDFGDGRVVKRTITGNAAHYVMDHHGNLLDVVPGIYGANAFQRVISGSLRLWSQLQNVSDFKREIIIETYHKVRLKNIRKSWSKDLRTLGIFANVNLKPSRESLAVRAAIRTKSKRGIELPVIRSVQVRKRSAQVHKITTLREKTSQNVWQQIARLHYRDAKLDRGSRSVIEWQNPIQITASKALVESPVARLIRSFEKSLAEDTMRNEYEFHAKIHQWFCDGEAQKGFGYMNERVFREIFLTPANKPLIDLGEAYTGLLGDGLNN
>NZ_AP019860|3070990:3081778|3077873_3078785_+|WP_151968045.1|DBSCAN-SWA
MEFDQKTNKVLETLKKHAKKTQKRLQETPLNPIAVDGEQPISGYCIIDKVGSGGMGTVFKAQNVDTGELVAIKMLYPGHNNDPTILQQFINEGMMLINLKHPNILKGLDFGISKGFYFLAIELVEGESLISFIEKGFSFTEEHALRVALQVARALVYLEKRDIVHRDIKPANILLLGEKVKLCDLALAVETKNLEETESTCGTVEYISPEQAQGEKTLDSRSDVYSLGITCIHMISGKLPFEGDSGEEVMRRHIYEPINLNALGSFSPEVRKLLFGMTEKKQQDRLTATKVKEEIKTILRKRK

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_151968039.1|3070990_3072121_-	molecular chaperone DnaJ	A0A1V0SBY2	Catovirus	6.9e-32	31.2
WP_151968040.1|3072271_3073879_-	chaperonin GroEL	A0A219YK78	uncultured_virus	4.9e-164	58.1
WP_151968041.1|3073977_3074265_-	co-chaperone GroES	A0A221S3C8	uncultured_virus	1.9e-15	45.6
WP_151968042.1|3074307_3075915_-	chaperonin GroEL	A0A240F779	uncultured_virus	2.0e-165	56.8
WP_151968043.1|3076295_3077195_-	hypothetical protein	NA	NA	NA	NA
WP_151968044.1|3077210_3077567_-	hypothetical protein	NA	NA	NA	NA
WP_151968045.1|3077873_3078785_+	protein kinase	M1HZT4	Acanthocystis_turfacea_Chlorella_virus	1.6e-15	30.2
WP_152021992.1|3078871_3081778_+	calcium-translocating P-type ATPase, PMCA-type	M1HI01	Paramecium_bursaria_Chlorella_virus	1.8e-92	28.9

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>NZ_AP019860|3723830:3736625|DBSCAN-SWA
CATGAAAATCTTAATGGTACTAGGTATACTTATAATGCCCCTTGTTGCCCAGGTATGGCATCCCTCACAACAAACAGTAAACATACAGCATTACACTTTAGACATTCGCATAGATCAAAAACAAAAAAAAGTATGGGGAGACGTAACTTTTACAGTTTTCCCACTTTGGGATGATGTGGAAAAAACAATTCTCGACGCCGGAGATATGCAAATAAAAAAGATCATTTCCGAAGGCTACAACCTTAAATTTACACATAGCGGTCGAAAATTAACCATTGACTTCGGTAAGAAATACAACCGCGCGCAGCCCATCACCTTTACTATTTCTTACAGTGCTTTTCCTAAACGCGGGACATATTTTGTTCAACCAAACAAACACTATCCCAATAAGCCATATCAAGTTTGGACACAAGGAGAGGCCGAAGAAACACACTACTGGTTTCCGTGTTACGATTTTCCGAATCAGTTGTGTACGAGCGAAACGAAAGTAAGTGTACGTAAACCTTATATTGCCATTTCCAATGGAAAGTTACAAAAAGTCATCGAAGAAAAAGACGGATGGCGCAAGTTTCACTGGAAAATGAGCGTACCACATGTTTCTTATCTTGTGAGCCTGGTAATTGGAGAGTTCGTCGAACTTCAAGATAACTTTGAAGATATTTCGTTACAGTACTATGTACAAAAAAAGGATGCTCCCAATGCACTGCGTTCTTTTGGCAAAACGCCTAAGATGATGACTTTTTTCTCTGAAATCACCGGAGAAAAATACGCGTATGAAAAGTATGCGCAAACAGCTGTGGAAGAATTCACCTTTGGCGGGATGGAAAACATCTCCGCCTCGACCTACACACAAAATACGATTCACGATGAACGCGCCCATCTCAACTGGAGTAGCGAGTCGCTTGTTGCTCATGAACTTGCCCATCAATGGTGGGGAGATTTGCTCACCTGCCGCGATTGGTCACAAATTTGGCTCAATGAAGGTTTTGCCACCTACTATACAGTGTTGTGGTTAGAACATGACTTGGGCAAAGACCAAGCAAAAGAAGAACTTTTGGGAGAATACGACTGGTACATGGGTTCGGACTTTCACCCCGTAGTGTGGAAAAATTTTGAACATCGCGATGATGTATTTGATTCCCATGCATACGCCAAAGGTGCATGGATTTTACATATGCTGAGAAACAGTTATGGACACGACAACTTCATACGCGCCACACAGCTGTATTTGCGTCGTCACAAAGGGAAAGCTGTCACAACCATCGATTTGCAAAACGCGTTTGAAGACACCCTCGGAAAAAACCTCGATTGGTTCTTTGAACAGTGGGTCTACGGCATTGGACATCCTAAATTTGAAGTAAGTTGGAAATGGGATGCCGCGCATCATATGGTAGCAATTCATGTAAAACAAACACAAAAGTGGAAACCTTTTCGCGTCATAGTTCCCATCGAAGTAGCTACAAAATCGGGAAATACTGTCTACCATGTAGAACTGGAAGGTCGTGAACAACGTATTTACTTACCAAGTAAAGAACAACCACATTTTGTCGCTTTTGACAAAGATGGTACAGTGTTGAAGAAACTCGATATGCAACAATCGCAACCACAGTGGATTCATCAACTACAAAACGATAGTGATTTATACGGAAGACTTCGCGCCGCCAAAGCGTTGGCAAAATACCCCAGCACAGAAGCCATACTTGCTTTAGGGCAAGCACTAAAACAAGATTCTTTCTATGGTGTTCGCTCTCGTATCGCCGGTTTACTTGGGAACATTCACAGCAAACTAGCCGCCGATGCACTTCTCGCAGCACACCAAGATAAGGACGCACGCGTACGTGCCAGCATTGTCAGTGCGCTTCTCAAAAATCGCTTCAATCGCAAGGCCGTTGCGGTATTAAAAACCAAATTTCGCAGTGACATGTCGTACAGTGTACAAGCCAACGCCCTAAAAGCACTCGCCAAGTACGCAAAACGCGATGGGTCTGACATTGATCTCGACGACATGATGGATTTGGTATACGAAGCACTAAAAATGGATTCACATTTGGACGTCATTCGCCGTGCGGCATTAAATATCGTCGCTGACGTCGACAAAGAAGAAGGCCTAAAAATTCTACGAAAATGGGTAAAACCAGGAAAACCGGTAAGCTGCCGCACAACCGCGATCCGCGCTCTTTTTGCTAAAGAAAAAGGCAAAAAAACGTTGGTACTCAACAGTCTCATTCAGTTACTAGACGACCCAGACCATCGTATCCGCAGTACAGCAATCTCTCTTCTGGAGGAACTAGGCTCTAATAAAGCAATACCTGCTCTTATCAAAGTGGCGGAAAATGACGACCTACTGAGTGTACAGAATAGTGCAACAAAAGCCATTTCTGCTCTAAAAAAGTAGATGATCAAACATTTTACACCTAAAGTTCGTAGTATTAAAAATCTAATGCTACGAACTTTTGTTTTTTACCAGACAATTCGAGAACAATGCGATGACAATACCAAAAAAATTCCACAAGTATATTATAGAGAAAGAATTGGGGAGAGGAGGCATGGGCATTGTTTACAAAGCTCATGATCCACAACTTAGCCGTGATGTTGCTCTTAAGATTATGATCGAAATAGAACCAAAAAAAATAGAACGCTTCACGATAGAGTCGACTGCAATGGCACAGTTAAATCACCCTCATTTGATAAGAATCTATGATTTGGGCCGCAAACCACAACCATATTTTGTCATGGAATATATAGAAGGTGACACGCTAGAAGACCTCATTAAAGCAAAAAAAACCAAACCACGCGCTGTTGTAACAACTATGATAAAAATTTGTAATTGCTTACAGGAAATGCATAAGCAAAACATCATTCACCGCGATATTAAACCCGCGAATATCATGATTAGTAACAAAGGTGAACCTAAATTGATGGACTTAGGTTTGGCGAAGTTTACCAATTTCGACAGCAATCTATCCATACAAGGAGAGATTATCGGAACGCCACGCTATATGGCTCCAGAACAAATCAGTGGTAACACAAATTCAGTAACCGATATCTATGCAATTGGCGCGACGATGTATGAAGCTTTAACTCATACAAGACTGTTTGAGTCTGACTCGCCAACCAGTTTACTTTATCAAGTCGTGAGCGAAAAACCTACTCCTCTGCGAGAAATCAATCCTAAGCTGACGCCAGAGCTTGAAAAAATATGCCTAAAATGTTTGGAAAAAGACCCTAAAGAGCGCTTCCAAAGTTGCGAAGAACTCGCCAAAGCGTTGCAGCGTTTTCAAAATAGACGCAAAGCATCGCGCATTGAAAAAAAACAAGAAGCACAACGTAGTACACATAATATGGTAACCGGTTCGCTCATTTTGCTAGTCGTACTCATGGGCGCAGTATCATTTTATCTATACACAGCATACGAAAATCTTAAAAACGATAGCGAAGTAACCCAAAATCCAACGAGTAACCAAACCGAAAATGTGAAAAACTTTGCTAAGGTAAAAAACCACGCTAAAAATACCGTCCCAAAGCCCACAGCAAACAAAACAACATCTGCGGATGCACACTTCATAAATGCAAAAAAATATAAACGCTTAAAACAGTATTCAGCGGCACACACCAGTTTAAACAGCGCAATTGAGCTAGAAGACAAAGATATTTATCACTGCCATAAAGCAAATATCTATGCCCTAGAAAAAAAATACAACAAAGCAATACTACACTTACAAATGGCCCTAAAGCACCACCCAAAATCACCAAATATATACTACGCCATGGCCAATATTCACTTGCATCAAAAAAAATACGATTTTGCACTGGAGTTTTTATTGAACTTGTCTAACGAAAATGACAACCATGCCGCAAATAAAAACAACAGTTACATTCAAAAATTATTCATAATGGGAAATTGTTACCATGGCTTACTGAATTATAAAAAAGCGATATACTTCTGGCACAAAGCATTAGAACATGGTTACCCAAGTAACAAGAAGCTTTTACAAAAAATCGACCTAGCGAAACAAAAACTATCCACAGCCAAAAATCTCCCAAATGCTAAAATTTACTATGCACAAGCCAAAAAACTACAAGAGTCTAGAGCTACGGGTGAGAATAAACAACAAATACTACAATATTTGCATAAAGCTATTTTGGCTGATCCTAGTTTTGCAGCGGCTTACAATTTTAGAGGAAATACATACAAAAGTATGAGTTTGAATCTCCTGGCCATCACAGACTACAGCAGTGCGATAAAATACCAACACAAATCTATTTACTATCGCAATAGATTTGCCATTTATCTAAATACAAAAAACTACAAGAAAGCACTCAACGACATAGAAATATTAACCAGTTTGCAACCTCAAATACATCATTTTTGGGCACTAAAAAGTGAAGTATTGTTTCATTTGAAAAAACCATATGAAGCGATAAAGGCCATTGATCATGCAATAACGCTTGACAAAAAAAACGCTCAATATTATTTCTTGAAAGGTAAGATTTTTTTTGGAAATCGCAACTATACGCAAGCGATAAAATGGCTGCATATTGCGCAAAAATATAACCCGAAACTTCCATACATCTATCGCAAATTAGGCGATACTTATTTTTCACAACAACAGTATAAGAAAGCAATTGATTTTTGGCAAAAGGCCCATCAATATGGGTACCGCCCCCAAAAGGAATTAACAACAAAAATAACTAAGGCACGCGAACGCCTTAAATAGTAAGGTGTGTTTAGAAAAAAATGTTTTTTAACTACGAAATCTAACAACAAGTTCGAGAATTATGATGACAACTCCTTTTGAACAAAAACAACAAACGGCACAAAAATTTGGTAAATACATAATAGAAAAAGAACTAGGCCGTGGAGGGATGGGCATCGTGTACAAGGCATACGACCCACAACTCCACCGCCATATCGCCTTGAAGTTAATTTTAAATTTAGAGCAAAAAAATATTGATCGTTTTATGAAAGAATCAAAGGCCCTCGCACAAATTACTCACCCGAACTTGGTGACTATCTACGAATGTGGTAGAGACCCTCAGCCGTATTTTGCGATGGAATATATCGAAGGCTCTACTCTACAAGACCTAATTTCGGAGAAAAAAACCAAACCGTTTTTTGTCGTAAATACCATGATAAAAATTTGCGACTGCCTACAAATGATGCATGAAAAAAACATTTTACACCGCGACATAAAGCCTGCGAACATCATGATCGACCAAGCAAATGAACCCAAGGTCATGGATTTGGGACTGGCTAAATTTATCCAAACAGATAGTTCTCATTCCACGGAAGACTTTATGGGAACTCCGGCGTACATGTCCCCAGAACAAATCGCTGGCAAAACCAATAAAACAAGTGATGTATATGCTCTCGGCGTTACCATGTATGAAGCTCTGACACATCAAAAGATGTTTGAAGCGGATTCTTCGACAAACTTGCTGTACAAAATTGTTCGCGAAACACCTGTTCCTCCGGGAAAAATCAATCCCAAAGTTGCTCCCCAGATAGAAAAAATATGCCTTAAATGCGTACAAAAGGACTCAAAACAGCGTTATCAAAACTGCAAACAACTCAAAAAGGCGTTGGAAAATTTCAAAAAAGCACGAAAAACCCAGCGTACGGTGCTGAAAAAAAACCAGGAGTACAAATTACAAAAACTGACGGTTGCGGCATTAGGGGTGTTACTTTTGTTATCGGTCAGCGTGTCATTTTTCTTTTATAACTCATATAAACAACTGAAGAAGCAACATGGAAATCAACATGCCGCCTCACACGATAGTACCTCACAGAACAACGATCGCGATAACGTGGTGGTAGCAAAAAATACACAAGAAAATAAAACGGCAAACAACAACGTAGCGAAAGATCAAAATGCACAACCAAGTAACCATCACAAAGAGAACACAACATCGTATTCGGAAAAAACAAGCCAACAAAATGAAACCGCAAAACGATATTTTCATCAGGCACTTGCTTTTCACGAGCAAGATCAGCCTCTTAAGGCCATAGAGTACTTTAGTCGTGCGATTATGCATGCCCCCCGTTACGAAAAAGCCTATTCAAATCGCGGAAGAATTTACTTAAATCAAGGAAAAGTCAAGGAAGCGTTAGCAGATTTTGATCGAGCTCTTACGTTTAATAAAAGTGCCGCTAATTTTTATGACAAAGCCGTGGCTTTGAGAAAATTACAGCAAAATCAGCAAGCGCTCACTACGTTAAATTTAGCACTAGAATTACATGATCAGGACCCTCGCTATTGGCAACTACGCAGTTTACTACACTATGCTTTAAAAAATGTAAATCAGGCCCTCAGCGATATTGACCGTGCCATACAACTGGACAAAACAAACGCTCAACATTACTCCAATAAGGGAGCAATATATCTTTATCAAAAAAAATATAAAGAAGCGCTGAAATATCTCAATAAAGCGCAGAAGCTCAATAGTGAATTAGACAATGTTTATTACTACAAAGGTGAAATTTACTATATTCATAAGAAGTACAAAAAGGCTTTAAAGTACTTTCAGCGTGCAACAAAATTGAATAAAAAATATGCGGTTGCATATTCGAAAATTGGCGATTGTTGTTATAGAGTTGCAGAATACAAAGTTGCTATTTTTTCGTGGAATATGGCTTTGAAATGTGGTTATCCTAGCCGACAGGAAACGTTACGAAAAATTGATCTGGCAAAGCAAAAAATGAAGTAATAAAAAATATAGAGGTATTGTCCTAGATTTTAGGACAATACCTCTATATTACAAAACGATTATAGTTAACTACCTGTACTACCAAAACCGCCGCGTTCATTGTCCTCCACTTTACCTTCCACTATTTGAGCTTGCTCAACTTTGTGTAGTAGCGCTTGGGCAACGCGTTGGCCTTTTTCTAATTTGACTTCTGTTTGTGTGGCGTTTTCAATGCCAATAAAAACTTCTTTATGGTAGTCACTGTCAATGGTACCGGGAAAAATATTGATTCCCAATTTAAAAGAAGATGATCGTGACTTAACCGCGACGTAAAATCCCTCGGGAATGGCCATTTTGATATTCGAAGGAAAAAATCCACGTTGTCCCGGTTGTAGTGTTACATCTTCTTTCACATACAAATCAATTCCTGCTGCTCCAGGAGTTTGATACTTTGGTAGAGGTAGAGATTCATCAATACGCTCAATTTTCAGCGTTGTCTCCATGAAAACATTCCTTTATGACAGTAGGCACTATCGTACCTATAAGTTCTTTAATTGCCTGCGCGTATACACGTATTTCCCATTGTGAGTGACTATCGTCGCGCAGTTTTAAAAATTTGATTAAATTGTTTAAGTCCGTACGTCCGATAAATTTTGTCATCAAGTTTTGTGGAAGTACCATACGAGCCTGTTCGCGGCATACGCCTTTTTCTAAAAGATTATCGTATAGTTGCAGCGCTTGTTTTGTCGCCACTTCAATCTCTCTGCCTAAATTTTCTTGAGTTTGCGCGTCGAGTTGTTCGCTCCCGACTTGTTTGTTTTTTTTATCTTGTTTGCGAAAATTTTGCGGAATGTAGAAATCAATATTTTCGCTTGTATAACGCCGGCTTACTTCATTGTAGCTCCACATACGATGGCGAAACCATTGCCTGGTAACAAAAAGCGGACAGTACACTTCAAATTTAAATACCACCATTTCCAGAGGAGAGGTATGTTGATTTTTAATTAAGTAGCGTAGTAGTTTATGGTCTCTTTCCCTCATCGTATCGGTATATTTATCATAGCTTACTCGGGCAGCATTCACGATATCAACTTCACTGCCCATGTGGTCCAAGAGTGTAATGTAGCCCTGATCATTATCCAAAACACGGATGGTCTGTTTAGGCTCCACAAACTCCTCCTTTACACATATTGTGCGCTTCTACAAACACTTGTCCTTGTTTTGCCATAGCTTCTTCATATGAACACGGTACTATGGGCTGTCCCCCGCGTGCACCATCTGGATAACAAGTGATTCCACGTAATCCATGTGCATATTTCGCAATACATTGCACAAAGTTTTCCACCTTGTCTTCGTTATTGTGTTCCGAACCCCACCGTGGTAAATTAATGGTACTACTTACGGCTTGGTCGATATATTTCTCCACATCGTACTGAAACTTGATACGCTTCTCATAGTTTTGCGCTAAGTCAATAGAAGTTTCGATACTGTCAGGATGAATTCCACGTTCTTCGATGAGATATTTTGCGGTACTGTCCACAATGTATTCGCAGTGCCATTCATTGTTGCGCAGATATCTTCTCTTGTACGCCACACTGTAAATAGGCTCAATACCAGTTGTTGTACCAGCGAGAATACCTATGGTACCCGTAGGGGCAACAGCACGCTTGGCCACAGGTCGCGAAATGTTGAGTTCATCCGCGTAGTCATTGGCAATTTTATCAGAAATATCGCGATAAACCGTCAGCCACTCATGCAACTCATCACTAACTTCATAACCATAGTTACGCATAAGAAGCCATTCGTGAATTCCCATAATTCCCAATCCCAAACGACGATTCTTCTTGCGTGTTTCGTAAATTTTATCGAAAGGAAGCTGTGAACGTAAGGTACCCAATAGCAAAAACTTTGTCGCAAGCTCCACGACAGATCGTAGTTCATCAATACTGTCGATTTCGGCGAGATTGATAGAGCCTAGGTTACAAACATCACTATCATCTTCACTGGTAATTTCGCAACAGGCGTTACGCGCTGTTTCGTGTTCTTTATCGTAAAAGTTCATCGAGAAACCCGGTTCACCGTTCATCATGGCGTACTTGGCATTTTCGCGGAATATATCTCCCACTTCTCCTGTTTTTTTATAGTTTTCCAACCACTCAGTGTTGTAGATAATACTAATATTAGTGCAGTCAAGAGGTGCAGACAACGTAAAATCGCGTTGTTTGGCCTCTCCATACGTTGTGCTGGTTCCAGGAATAACTTGTGAATTCCAATCTTTTACGCGTAACATCTTGTGAGCATCGGCATGGTTCCAACGTAGTCCCGCCCAAATAGCGGATCTCCGTGAACCTCCTTGTTGCACATAACGGCCAATCTCATTGACAATTTTCATGGCCTTGATTGGTCCACTTGCCAAACCACCCGTGCGTTTGAGCGGTGCTCCTTCGCGACGATAGATGGAATAGTCATTGCCTATTCCCCCTCCTGAAGCAAGGGCTGACTGTACTTTATACACCAAATCTGCCCAATCTTCACGTGTATCTTCCTCGGATTTAAATAGATAACAGTTGTTATAGTACTTCACCCCTCTATTTGTATAGTAGAGGTAACGTCCACCGGGAATAAATTTTTTCTCTACGATAAAATTGGCTAAGGCATTTTTTTCATCTTCACGCATTTCGAGACATACTTCGTTTACAACACTGCGACTCAACTTTTCCCACGTTTCACAGCCTTCATGGCGATATTTACAGTTGAATACGTTTTCCGCCAGACTATTTCTAAATTCGCTTTTTGTAATCAACGGCGTCTCCTTAAAAAAATAAAAGGTGGATATAGCGAGTATATCCACCATTTGAGAGATGAGTTAATTATCTTTTTGTGCACGAAAAGATATGTTTTTAGGGTTTTTATTATACTTTAATACGGTTTACTTGACAAGTAATTTACGGTTTTTATTCAAAGAAATTTAGTGAGGGGGTATCTTTATTATGTACCGAATTTTTGTAATCTGCCATTTTTTTTGAAAAATAGATAGCCAGACCTTGAAAAGACTGATAATTTTTTTTGAGAAAAGCTAAAAATGCTGAGATATCAAGGGGAAGGAGACATGCAACGTCTATTTTTCGTCGCTTTGCAGAAGAGCCCATTGTGCTTCCCAACCCTTTTTCTCACAATAAGCGCGTAATTCACGATGGAGAAATTTGCATAGCGCATACATCAAACAAAGATCATCAATCCACCCAATAATCAGAAAAAAATCAGGTAAAATATCTATTGGTGAAATAATATATACACAAGTAAATGCCACAAGCATTATTTTTGCTGGATGCATTTCTTGTAGTTTTCCATGACGATAATCACGTATAATAGATATAAACAGCTGTGCTGCGATCCATAGTTTTTTATTAAGTAATAAACTGTACCAACTATTCTTTGACATAGGCCTTTGGGAAAAAAGAAATGGTGTTTGTAGATATTTAATTATATGGCAAAAAAATAGCAAAAGTCGAGAAAAATAATCGGGAGTGGGAAAGGGAGCGGGAAAGGGAACAATAATATGCGAAAATCATTTAAGAACGGTATTTGTTTTTTAGGCAAAACAACTTGCCACTATGCAAAAAACTTACGGGGAGGTGTTTATACATTATTTTTATTTCTTTTGCTTACCTTGGGTGGTGTTACCTACTATTCTTCGGGAGTATTGTCGTGGACTTCATGTGGTATTTTATTGTGGCTATGTCTGGGAATTAGTTTACTAAATCACAGTCTCCACAGTGACAAAAATAATATTATTGAAGGCTTTATTAGCAAAGAATCCTCTCCTTATCTAGAATATTCCAAACAACTTTCTCCATTATTTATCCTCATCGTCAACATTTCCTTAGTATTTGTGCTGGTTGTACTTTTGTGGAAGTTGTCTTTCCTCGAAACATCTTTCTTTTCTTCATCTTCGCAAAACTTTGACGATTGGGGAATTTACACCATTGATTTAATAATGAAAGCTGTACTTTTTGATATCCCCGAGGTTTATGGTCTCAACTTAATTGACATACAACATCTAGGATTTATTGGTGGAACTATTGTACTCATCATGCGCGTAGCAGTGTTGGTACTTGTGGTTGGCGCCATATTTCATTGGTCAGAATTGCGCAAAACAATTTATAGCTGTCTACAAATTTTAAAAACCTACCCCGACATTGGTCGCACGAAATTATTACTTATTTTACAAATGTACCCACGACAATTATCGTTTATTGTTAAACAGTGCCAGGACCATAAATATGGCGAAATTACCCGTAAACGTTTGTGGACCGTTTTAGGTGAATCCTTGCGTATTGAAATTTTGCCATTTGTCGAAAAAGAACTGCGCAACACCAACTCCATGGACATCCAAATTGCGTGCCTGAAAGCCCTAGAGCATTTAAAAAACGGTAGTATTGATGTTGTCTCTGCGTTTATAAAAGAAACCAGACCTTTTGAAGTAACACAACAAGCCTGTTATACACTCGCGAGCTGGAATACACCGCAAAGCACAGATCTGGTAAAAAAAGTACTACAATACAATGACCAAAGTTTACGCAGCGTTGCCATTCGAGCGCTGGCAAAAGTAGACTACCATCTTGTCGGAGATATTTTCACCGAAATTATGTACAATACCGATAGTAGCAAGGAAGAGCGTTTTGCGACGAAAGATGCCCTCATTGAACTTGGTCAATTTACCGAAAAAACCCAACGGGAAATACAACAGACTTTAGAAACTTCCCATAGCCCCGCCAATCGTCGCTTTTCCGCAATGGTGCTCGGAGGTGTTGGCAATATAAAAAACCTGACACTGTTGTGCAAAACCCTAAAAAACGACGAAGATGCCGATACGCGTTTTTATGCCATCCAAGGTATACATTCACTGGCGAAAATGAGCATTGACACCCAACAAGTGCATGTCAATATCTGGCAAAATGTCATTCCGCAAGTCATCGATATGGCAGATAACGAAACTTATGATTTGGCAAGAGCGGAGTCCATACACACTTTGGCCACAATGATCGACTTCTGTAGGTATGATGTTATTTTTGGCGATATGCTTTCTCCGCTGGCAGATTTTTTACCCAAATGGCAAGACAGTGATAGCGCACACATCATGGACGCTGTCCTCGATGTTTATAATACAGCGGAATTATGGCGTGATACATTAAAAATAGATTTTGACAACGTAGATTCAGGGTTTAACGAAATGGCTGTCAGTGTTTGTGTAACAGAGGCGTACCAAAGTAATCCTTTAGTGGAAATGGGACAAAAACTCAACTTTTATCAAAATAATAAACAACCACAGCAAGCAAACCATGACTACGAATTTTTGAGCAAAATGTCCGGACATAATGGTATCGAAGTGTGGCTAGTGAAAGACCGCGAGAACGACACACAAAAAGTCTACAAATGTGCAACGCAGGAACAACAAGAGAAGTGGATTGGAAAAGAAATACTTCTTTTACGGAGGTTGCAACACAAAAATATTGTTTCTCTACAGGCCATTCACCAAGAAAATTTTGCATTTACCATGCCGTTTGTCACCGAGAATACGCTATGGAAAAAGTTGAAAGAGGGTCCCGTACAAATCGAAGAATTGTACACCATCGCCACCCAACTCGCCGATGCCTTACAGTATATTCATCATCAAAACGTTGTATATTGTGATCTAAAACCCAAAAATATCTTATATGATTGCGATGTAGTCACTTTAATAGATTTTGGAGGGGCGTATTGCGATGGTTTTGACTTTAAACCACAAGGAACGCCTCCATATATGGCACCCGAAATAATATTAGGGCATTCCCCCACAGCAACGGCAGATGTATACTCTTTAGGCGTTTTGTTGTATCGTATGCTTACGGGCATGCTTCCTGCGGGAATCGCACGACCAACAGTTGGTCAATGTGCTCCGATTACTTTGCCATATATTTTGGCAAAAGCCACCGAGTTCGATCCGCAAAAACGCTATGAAAGTGTGCAAGCTTTTTGGAATGACTTTTCTTTACTCAAGGAACAATTCGTCACGCGCCGCGACAAACATTTGCTTTCGTTGAGCAACAATGAGAACCTTACCACTTAA

Protein sequences of DBSCAN-SWA_3

>NZ_AP019860|3723830:3736625|3731675_3733319_-|WP_173013300.1|DBSCAN-SWA
MITKSEFRNSLAENVFNCKYRHEGCETWEKLSRSVVNEVCLEMREDEKNALANFIVEKKFIPGGRYLYYTNRGVKYYNNCYLFKSEEDTREDWADLVYKVQSALASGGGIGNDYSIYRREGAPLKRTGGLASGPIKAMKIVNEIGRYVQQGGSRRSAIWAGLRWNHADAHKMLRVKDWNSQVIPGTSTTYGEAKQRDFTLSAPLDCTNISIIYNTEWLENYKKTGEVGDIFRENAKYAMMNGEPGFSMNFYDKEHETARNACCEITSEDDSDVCNLGSINLAEIDSIDELRSVVELATKFLLLGTLRSQLPFDKIYETRKKNRRLGLGIMGIHEWLLMRNYGYEVSDELHEWLTVYRDISDKIANDYADELNISRPVAKRAVAPTGTIGILAGTTTGIEPIYSVAYKRRYLRNNEWHCEYIVDSTAKYLIEERGIHPDSIETSIDLAQNYEKRIKFQYDVEKYIDQAVSSTINLPRWGSEHNNEDKVENFVQCIAKYAHGLRGITCYPDGARGGQPIVPCSYEEAMAKQGQVFVEAHNMCKGGVCGA
>NZ_AP019860|3723830:3736625|3726315_3728547_+|WP_151968499.1|DBSCAN-SWA
MTIPKKFHKYIIEKELGRGGMGIVYKAHDPQLSRDVALKIMIEIEPKKIERFTIESTAMAQLNHPHLIRIYDLGRKPQPYFVMEYIEGDTLEDLIKAKKTKPRAVVTTMIKICNCLQEMHKQNIIHRDIKPANIMISNKGEPKLMDLGLAKFTNFDSNLSIQGEIIGTPRYMAPEQISGNTNSVTDIYAIGATMYEALTHTRLFESDSPTSLLYQVVSEKPTPLREINPKLTPELEKICLKCLEKDPKERFQSCEELAKALQRFQNRRKASRIEKKQEAQRSTHNMVTGSLILLVVLMGAVSFYLYTAYENLKNDSEVTQNPTSNQTENVKNFAKVKNHAKNTVPKPTANKTTSADAHFINAKKYKRLKQYSAAHTSLNSAIELEDKDIYHCHKANIYALEKKYNKAILHLQMALKHHPKSPNIYYAMANIHLHQKKYDFALEFLLNLSNENDNHAANKNNSYIQKLFIMGNCYHGLLNYKKAIYFWHKALEHGYPSNKKLLQKIDLAKQKLSTAKNLPNAKIYYAQAKKLQESRATGENKQQILQYLHKAILADPSFAAAYNFRGNTYKSMSLNLLAITDYSSAIKYQHKSIYYRNRFAIYLNTKNYKKALNDIEILTSLQPQIHHFWALKSEVLFHLKKPYEAIKAIDHAITLDKKNAQYYFLKGKIFFGNRNYTQAIKWLHIAQKYNPKLPYIYRKLGDTYFSQQQYKKAIDFWQKAHQYGYRPQKELTTKITKARERLK
>NZ_AP019860|3723830:3736625|3730602_3731019_-|WP_151968501.1|DBSCAN-SWA
METTLKIERIDESLPLPKYQTPGAAGIDLYVKEDVTLQPGQRGFFPSNIKMAIPEGFYVAVKSRSSSFKLGINIFPGTIDSDYHKEVFIGIENATQTEVKLEKGQRVAQALLHKVEQAQIVEGKVEDNERGGFGSTGS
>NZ_AP019860|3723830:3736625|3733634_3733958_-|WP_151968504.1|DBSCAN-SWA
MSKNSWYSLLLNKKLWIAAQLFISIIRDYRHGKLQEMHPAKIMLVAFTCVYIISPIDILPDFFLIIGWIDDLCLMYALCKFLHRELRAYCEKKGWEAQWALLQSDEK
>NZ_AP019860|3723830:3736625|3730996_3731686_-|WP_151968502.1|DBSCAN-SWA
MEPKQTIRVLDNDQGYITLLDHMGSEVDIVNAARVSYDKYTDTMRERDHKLLRYLIKNQHTSPLEMVVFKFEVYCPLFVTRQWFRHRMWSYNEVSRRYTSENIDFYIPQNFRKQDKKNKQVGSEQLDAQTQENLGREIEVATKQALQLYDNLLEKGVCREQARMVLPQNLMTKFIGRTDLNNLIKFLKLRDDSHSQWEIRVYAQAIKELIGTIVPTVIKECFHGDNAEN
>NZ_AP019860|3723830:3736625|3734075_3736625_+|WP_151968505.1|DBSCAN-SWA
MRKSFKNGICFLGKTTCHYAKNLRGGVYTLFLFLLLTLGGVTYYSSGVLSWTSCGILLWLCLGISLLNHSLHSDKNNIIEGFISKESSPYLEYSKQLSPLFILIVNISLVFVLVVLLWKLSFLETSFFSSSSQNFDDWGIYTIDLIMKAVLFDIPEVYGLNLIDIQHLGFIGGTIVLIMRVAVLVLVVGAIFHWSELRKTIYSCLQILKTYPDIGRTKLLLILQMYPRQLSFIVKQCQDHKYGEITRKRLWTVLGESLRIEILPFVEKELRNTNSMDIQIACLKALEHLKNGSIDVVSAFIKETRPFEVTQQACYTLASWNTPQSTDLVKKVLQYNDQSLRSVAIRALAKVDYHLVGDIFTEIMYNTDSSKEERFATKDALIELGQFTEKTQREIQQTLETSHSPANRRFSAMVLGGVGNIKNLTLLCKTLKNDEDADTRFYAIQGIHSLAKMSIDTQQVHVNIWQNVIPQVIDMADNETYDLARAESIHTLATMIDFCRYDVIFGDMLSPLADFLPKWQDSDSAHIMDAVLDVYNTAELWRDTLKIDFDNVDSGFNEMAVSVCVTEAYQSNPLVEMGQKLNFYQNNKQPQQANHDYEFLSKMSGHNGIEVWLVKDRENDTQKVYKCATQEQQEKWIGKEILLLRRLQHKNIVSLQAIHQENFAFTMPFVTENTLWKKLKEGPVQIEELYTIATQLADALQYIHHQNVVYCDLKPKNILYDCDVVTLIDFGGAYCDGFDFKPQGTPPYMAPEIILGHSPTATADVYSLGVLLYRMLTGMLPAGIARPTVGQCAPITLPYILAKATEFDPQKRYESVQAFWNDFSLLKEQFVTRRDKHLLSLSNNENLTT
>NZ_AP019860|3723830:3736625|3723830_3726224_+|WP_173013299.1|DBSCAN-SWA
MKILMVLGILIMPLVAQVWHPSQQTVNIQHYTLDIRIDQKQKKVWGDVTFTVFPLWDDVEKTILDAGDMQIKKIISEGYNLKFTHSGRKLTIDFGKKYNRAQPITFTISYSAFPKRGTYFVQPNKHYPNKPYQVWTQGEAEETHYWFPCYDFPNQLCTSETKVSVRKPYIAISNGKLQKVIEEKDGWRKFHWKMSVPHVSYLVSLVIGEFVELQDNFEDISLQYYVQKKDAPNALRSFGKTPKMMTFFSEITGEKYAYEKYAQTAVEEFTFGGMENISASTYTQNTIHDERAHLNWSSESLVAHELAHQWWGDLLTCRDWSQIWLNEGFATYYTVLWLEHDLGKDQAKEELLGEYDWYMGSDFHPVVWKNFEHRDDVFDSHAYAKGAWILHMLRNSYGHDNFIRATQLYLRRHKGKAVTTIDLQNAFEDTLGKNLDWFFEQWVYGIGHPKFEVSWKWDAAHHMVAIHVKQTQKWKPFRVIVPIEVATKSGNTVYHVELEGREQRIYLPSKEQPHFVAFDKDGTVLKKLDMQQSQPQWIHQLQNDSDLYGRLRAAKALAKYPSTEAILALGQALKQDSFYGVRSRIAGLLGNIHSKLAADALLAAHQDKDARVRASIVSALLKNRFNRKAVAVLKTKFRSDMSYSVQANALKALAKYAKRDGSDIDLDDMMDLVYEALKMDSHLDVIRRAALNIVADVDKEEGLKILRKWVKPGKPVSCRTTAIRALFAKEKGKKTLVLNSLIQLLDDPDHRIRSTAISLLEELGSNKAIPALIKVAENDDLLSVQNSATKAISALKK
>NZ_AP019860|3723830:3736625|3728608_3730537_+|WP_151968500.1|DBSCAN-SWA
MMTTPFEQKQQTAQKFGKYIIEKELGRGGMGIVYKAYDPQLHRHIALKLILNLEQKNIDRFMKESKALAQITHPNLVTIYECGRDPQPYFAMEYIEGSTLQDLISEKKTKPFFVVNTMIKICDCLQMMHEKNILHRDIKPANIMIDQANEPKVMDLGLAKFIQTDSSHSTEDFMGTPAYMSPEQIAGKTNKTSDVYALGVTMYEALTHQKMFEADSSTNLLYKIVRETPVPPGKINPKVAPQIEKICLKCVQKDSKQRYQNCKQLKKALENFKKARKTQRTVLKKNQEYKLQKLTVAALGVLLLLSVSVSFFFYNSYKQLKKQHGNQHAASHDSTSQNNDRDNVVVAKNTQENKTANNNVAKDQNAQPSNHHKENTTSYSEKTSQQNETAKRYFHQALAFHEQDQPLKAIEYFSRAIMHAPRYEKAYSNRGRIYLNQGKVKEALADFDRALTFNKSAANFYDKAVALRKLQQNQQALTTLNLALELHDQDPRYWQLRSLLHYALKNVNQALSDIDRAIQLDKTNAQHYSNKGAIYLYQKKYKEALKYLNKAQKLNSELDNVYYYKGEIYYIHKKYKKALKYFQRATKLNKKYAVAYSKIGDCCYRVAEYKVAIFSWNMALKCGYPSRQETLRKIDLAKQKMK

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_173013299.1|3723830_3726224_+	HEAT repeat domain-containing protein	A0A0P0IY26	Acinetobacter_phage	4.7e-22	24.4
WP_151968499.1|3726315_3728547_+	protein kinase	G9L673	Escherichia_phage	4.1e-20	29.1
WP_151968500.1|3728608_3730537_+	protein kinase	A0A2K9L111	Tupanvirus	1.9e-21	28.7
WP_151968501.1|3730602_3731019_-	dUTP diphosphatase	M1HWP7	Paramecium_bursaria_Chlorella_virus	3.3e-16	37.2
WP_151968502.1|3730996_3731686_-	FAD-dependent thymidylate synthase	A7XXI6	Thermus_virus	1.9e-45	50.5
WP_173013300.1|3731675_3733319_-	hypothetical protein	A0A1J0GVZ2	Streptomyces_phage	3.3e-131	46.2
WP_151968504.1|3733634_3733958_-	DUF1232 domain-containing protein	NA	NA	NA	NA
WP_151968505.1|3734075_3736625_+	protein kinase	G5CT46	Megavirus	2.0e-10	25.8

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>NZ_AP019860|6514664:6589538|DBSCAN-SWA
GTCATTGATTGTATCCGTTACAAATATTAGCAGATTGCGTGGTGTTTGTCGTTTTCCTTACCTGGGGAGTTTTTTCCGAACGGCACAAATAGAACAAAAGAATCATTTCAACTATGTACATAAAGCAAAACAACAAATACAAGCGGAAATGTTTTATGCCAACACTAAAGGCCACAACATAAAAAAGAAGTAATAAAATCGCGGTATAGAAGTATTTGCGATTTTCTTTCCAAAAATAGCGAACCAAGCCACCAAGAAAACTCGCCACTAATCCACTGTGCATCCAAGTCCCCAAAGAAAGATCAAATGGTCTGGATACATAACTGTACAAAACACCAAAGTCAACTGTTGTAAAAAGTTTACATTCTCGTTGAAAAAATAAAAACAAAAGAAGAGGAATGCTGTTCCATATGGCTATGGCAAAGTAAAAAACCAAATATTTATGCGTGCGCAGTTGCTTTTTTTGCATCCAACTGTACGCCAACAGCCCACAAGTCGCTCCGAGCATCCCGCCAAAATTAAGGTCATAAATAATTAGGCTTACAACGTTGGCAACTACGGCGAATAGAAGCATATGCCAAAATAGAAAAACCCGACCTTTACTGATCTCAATTCTTCGCGCAACAAAGTAAAAAGCAATGATACTTGTCAGAAATGCTGGCCAATTTTCATGAATAAAAGCGGTAGAAAAGAGCGTCCACGGTTCAATCCACAAAATATCCGACCAACGGAAATAGTTGTGACCGGAGAACCAATTGCAAATGGCCCAAGAAAGAGGAGAATCTACCTCATTAGCGTTTGAGGACAGCCAGAATAAAATAGAACAGACAACGATCACAGAGTATGTAAAAGGGCTTCGTGCCTTTGCCGTGTGTTTGATCGATTTTTTTTGCACAAGAGCCATGAAAGACTCTGCCTGTTCTACATCGGGAAAGATAAATTTCTGTCGCACTTTTTTCCATCTCATCGACACACAAACGTCTACTTGTGGTTTTACGCGGTCGTCCAAGTCTATTGATGCTTTTACATATGAGAAGGAAGTAAACGGTAAAGTAATCTCTCCTAAGGTAACGCGAAGTGTATTGACACCATGCATACCTGCGATTCCTAAAATTCCCACCCATACTATGGGAATCACTTTCCATAACAGCATATGGAAAATGGCAAAACCTAAAAGAAAAGTGAGAAAGAAAAACAAGGTATTTTTCGCCATTTTGTATCCAGTAATAATAAAGCCTTCATCCACGACAAGGATTTTTACATTGCCAAAAAATCCCCAAAAAGGATATGTGAAAAAACCAAATAGCCAATATCTCGGTGGGATTTTGACTTTATATTGCATGTGATCAAAAGACTCCGCGTCTAACTTCATCTCTATTGGATTTTTAGATCTGTTAACGCTTGTTGGCAAACTCATGACTGGTTTTACTCCATGACAAGTTCTCTGCGACCAATTCGCTAGAGTAAGATTTACAGCTGATTCTATTGGATTTGATGGTCATATTACACAAAGAAAAAAATGAAACCACAGAGGCCACAGAGAAATTTTCTTTTCCAAAAAAGTAAAATACTGTAAACCACTACAAATATAAGACTTATTTGTTTTTTGAAAGAATACTGTTTCTATTTAGTTTTTTATAATTGTTTCTCTGAGACCTCTGTGGTTTTATACCAACCAAAAACGTTAGAGAATCGGATTTACAGATATTATAAAACTTTTAAGAAAAATAAAAAAATAGCTTTTTATATTTTTTTGCGCTTGTTTGTTGACTATCTTTGATACAACTCTAAAATAATCTATAGATTTTCGCGAATGATTAGACAATTGGTTCTCACAGCAAAACGGAGAAAAAATGAAAATAGGTTTAGAAATAGCTGGTTCTGATTACATATACATCTTACCAGATCAAAACGAAATCACCATAGGAAGGCAAAAGCGCAAACCTGGACAAAAAGGCAATGACGTAGTGATTCGCGTTCACGGTAACGACGAAGCCAGTCGTGCCATTAGTCGTAATCACTTAACTCTTATGTGTCGTTTCAGTGGCATGTTTATTTGCGATCATAGTACTTTTGGTACAAAGGTCAATGGACAACAAGCGATGCGCGATAAAAAGTTCGCCATTGATGTTGGAGATCGCATCAACATCGCCGATGTTCTTACGCTAACCGTTGTAAAACTTCCCGATAGCTACGTGGATGAACTGGACGTAGCTGCCACGACTCAACAACAAAAAATCACTCTCCCATCTGTAGGAGATTGCGCTACCGTTGCCCCTGCGTTTGAGTCACCGGTAACAAACAATGCTCCTGCGAGTAGTGTTGGTGTGATGAGTACCGACGTAGAAGCAGATGTGGGTTGTTTTGTGCGCAAGAAATAATCAAAAGGAGAAAAGATGCAAGCAAAAGAAGTATTACAACTAGTGAGAGATTGCTGCGACAATTTCCTCAAGCGCGAAGAAGCGAAACACGCGTTAGACTTTATTGATGTCAACACTTCGCGCATTCCCGAAAAAGAGGCGGACTTTGACTATTATCGCGAAATTACTCAGTACCTAGTTTCGCGGGGAAAGCTACGCGAATGGCTATGCGTTCTTCAACAAGACGGTCTGTCTTTTACCGCTGCGTGGGTTCAAAAAATAGATGAATTACAACAATCGATTGAATTTTCGCAAAAATTAGATCAATGGTCACTACCCCGCACGGTACTAACGTATCACGATGGACAAAAACAACACAAGATTTTTCTCATCGCTAAAACCAGAGTGGGTTTTGGTAAAGCGAAAAAATCACAGAACCCCGATGTCGATATCACCATGCGTGTTTTGCCGCTGCGTAGCCAGGAACTCGATCCTGGAAACTGGGCGCGCACCAAAAAAATTAGCCAACATCACGGCAACTTTGTACTGCGTAACAATCAGTTTTATGTCGAGCGCTTGGGAAAAAACGGCATTTTTACTCTAGAGGGAAATGAAATCGAAAAAGAGTCGTTGTTTACATTAAAAGACACAATGCAAATTCGTTTGGCGCAAGAAAGTTTACAACTCAAGTTAACAACAATTCGCGATCTGGAAACTCAGAACGTAAATTGTCTTTGTGTAGAGCGTGTGGATAATCATGTTCACCATTGTTATGTGCAGGTGATTCGTGAGGTGACGATCGGCGGAAAAAAGGCAGATGTCAATTTACCGGGGATGAATGGGGCGTTTCGCATTGTTACCGCGCAAGAGGGATGGAATGTCATTCCGGATGAAAGTGGATACACAAAGATAAATAGTGAGGTTATTCAAGAGCCTACTTTGCTTTGTAATCGCGATGTGTTATCGACCGGCCAGCAAGAGATTGTTTTTTGCATGACCGAAGACAATGATTTTATTGAATAGTATTGATTTCTTGAAATAAATTTAGAAGGTAAAACTTAAATGATGATTCCCGTTTTGCTCTTTATTCTTATAAGTGTTTTTTTCATTTGTTGCATTTATATTTGCATCAAAAAAAAAGTTTTTTTACGTTTCGTGTTAAGTCTTACTCCACTTTTCTTAATGATGGCTAGTGTCGCTTTTTCACAACTGGAAGATTCTTCAACATTTGCTCATTATATTATTCCTGTGACTTGTGTTGCAAATGTTGTCATTGCTATAAATTTTGCACGCCTTGCGCAGAGAAACGCTTTTTACTGGTCCATATTTGCTTTTATAAGTTATGGTTTTACCAATGCTATCATGCTTTGTTTCTTTAAAGGAAAAGTATACCAACGCGAAGAACAAATACGACATGGCTTAACTAAATGGAAAATTAATTATCAAGCTATTTTAGTGCTTTTTTTTGTCTATTTACCTTTCATTTTTCTATTCTTTTTTTCACCAAAGAAAATGGAGGAAAATACTCAATTTTCTTTTCGATCCCCATCCCCTGAAAATAATGTTCAGAGTAAAATGTGGAAAAATGCTAAGCAAACTTATTTTGAAAATATGAAAGTTAACAAAAATAAAAGACTACTTGTGTTTGTTATTTTCCAAATAGCAAATGCGCTCTTCGCAACGTTTGTTTTTATAAAAGCACGCGAAGGTAGGATAAAAGCTATTTTAGTGGGAATAATCGCGGCCACTATTACTTGGGGTCTCAGCAATTTTTTTCTAGTTCCACTTTGGTTAGATACTTTAGGCCAAGATCAAAATAACTTTGGCAGGCAAAACTTATATTGGTGGGCAATCGCAGCTCCTTTAACTCTTGGACTAAGTAATTTTACCTTCATTCTTTCACGTAAAAAATTAGAACCAAAAATATTTTTAGAAATTCGCTTATTGAGAAACAGAGCACGGTTATATGCACGCCAACGACAATATACAAAAGCAGAATTTTTCTATCTTAGATGCTTAAGTGTTATGCAGAACAAAACTCTATATTTTGAAACCGCTGAATTAATGAGCGAAATAGCACACTTATATCAACAAATAGGTGAATATACAAAAGCAGAGCAACTCTATACAGAAGCACGCTCGAAAGTAGACCACCCCATCATACTAAATAAATACGCCACTTGGCTTGATGAAAAAGGTGAAAAAGAGAAAAGCAAAAAACTCAGAGAAGAAGCCTTTCAAACGATAAAAAAGCAAATCAATAAAGATCCTCATGATGAATATTTATTGGAGGGTCTGGCAAGAATGTACCACGATAGCAAAAATTATGATAAATCAGAAGAAGCTCATTTGGAGGCTATTCAACTCGCAAAAACAAACGTTTCGAAACTTGAGTTGTTGAGTAACTTAGCCTCTTTTTATGTAGAAAGAAAACTATACCCAAGAGCAGAGGATACTTATATAAAACTGATTGAAGAGACACAAACTACATTAGGAACACATAACTCTATTTACATTTCCCTAGTCAGTGATATTGCCTTGCTATCTAAAGAAATGCGAAAGTATAAAGAGTCAGAAGAATTCTTTTGCGAGAATATGCAAGTAATAGAAAACGTTTTGGGAAAAAATCACTTAATTTACATTTTTAACCACATAGAACTGGCAAATTTATACAGTCAAATAGGTGAATATGGAAAAGCCGAACCTATCTATACTGAAATATTAAATATTGTTGAACAAATGAACGAAAAAAATAGCTTTGCATATGCTTCTTGTTTAAACCAAATGGGAAAAATGTATTACAAAATTGATGAATACGACAAGGCCGAAAAATACTATGAGAAAGCAAAGCAAATATACCATGACGTTCTGGGAGAATATCATCCTGAATACAAAGCTTGCCTAATGAATGAGCTAGAGCTATACCAAAAACAAAGAAAATCTCAAGAAGTAAACACGCTAATAAATGAAATCGAATTGTTGAATGAACAACAAAGTTTGTGTGAGTTACCAGAAAACACAGAGGTCGAAAATCTGCAGGTGACCATAAGTTTGGATGTAGATACTTTAAATCTTATTGTAGAGCAAGAAAGACTTAAACAAGCACAGAGAGAACAACAGGTAAACGAGCAGGAAATCATCGCTGCCTTTTTGCAAGGCAGAGAAGAAAATTTTACCAATGCGTTGCAAATGAGTCAAAACGCTATTTTACTGTATAGAAAAAAAGAGTATAAAAAAGCACTTGTGCTACAAAAAAAAGCCAGCGAAATTATACAAAAAACACATGGTAAAAATGATCGTTGTTATGTAACCGCATTAAACAACCTCGCTAAGTTATATGACAAAACAGGAAACTATGAAATAGCCTCAGAGCTATTTTCAAAAGCAGTAAATTTACGCGGAAAGATCCTAGGAACAGAACACCCTGATTACGCCACTAGTCTTGAGAACCTTGCCCACCTCCAATATCGTCAGAAGAAGAAACAGTCCGCATTATTCAATATGCTAAAAGCCGCGAATGTACACAATAAAATGATTTTGCGTATATTTTCCATCGGGGATGAAAAGCGCCTGGAGAAATACATTGACACTTTTGAAATACAATATTTTACGCTTCTTTCTATTTTCTATCAGAGCTACAAAGTTTTACACATTTTTTCCCCGCAAGTATGTGATCTTATTTTAAAGCGCAAGTCTTTACATCGCGAACTTACTTCTATCAAACGAGATAGCCTCTTTACGCAACAACGTCCTGATCTAGAAGAAAGTTTTGCAAAGTTAAGGCAAATAAAACTGCAAATAGCGCAACTGATTCTAGCTTCTACCGATGCGTCTTCTACGCAAATTGCAAAACTAGAAGCCGAAAAAGAGCAACTAGAGCGCGTTCTCGCAGCAGAAGTTCCCGAGTTAGAGCTCGAAAAGAAGTTAACTCATGTTTCTCACAGAGAAATCGCCAAACTCCTTCCCGCAGATTCCTTACTTGTTGATTTTGTTTGTTTTCGCGAAGTAGATGTAGAGTCTATGAGATACCTCGATGAACGCTACATTGCCATCGTCATCTACAACGAGCAAATATCCAAAGAACTCGCCTTTGTCGATTTAGGAGCGGCGAGTGAAATTGATGAACTCATTAGCAAATACAAAAAACACCTGACAACAGGGGAACGAAAAATACATGTTGTTGCGGAAGATGTTTTACCAGCAGAAAATACAACCGTAAAAACACAAGATGCATACGGAGAACAACTATTCCAAAAAGTATTTGCTCCTGTTTTACGCAAAACAAAAGACTGCAAACGCCTGATTCTTTCTCCTGATGGCGGATTATGCCTTCTACCATTCGAAGTTTTACCACAACCCAATGAGCGATTTGTGGTTGAAGACTACGAAATCAGTTACATAGATAGCGGCAAAGATCTTTTGCGATTTGGTTATCAAACCGCTCCCAAATCGCAACCTGTTGTTATTGCCAATCCTGATTTTTCTCTGAGTGGCGATCAGAGCTATACGGACATTAGAAACTCCATCCCTCAAAGCATCGTTGCCGAACTGGGACAAACCATTCAACGCAAAGTGCAAGAAACCAAAGCGCAATACTACTTCCCTCCTCTTGCAGCTACTCACAAAGAGGGAGTCACCATTGGTAAGATGTTGCCGCGTGAATACACATCTTTGATGGAAGAAAAAGCACTAGATTCTGCGATCAAAAAATTGCAAGCTCCGCAAATCTTACACTTTGCCACGCATGGCTTTTTCATGGTTGACGAACAACAAAAAGAAACAGATTTAGACGAAATGCAAGATCTAAACGAATCGCCCATTTTTCGCGGAGAAAAATTTCGCAATCCATTGCTACGCTCAGGTTTGGCACTAGCCGGTGCCAACACGTTTTTTGAAAACAAACAACCTGCACCAGACGCAGAAGATGGCTTGCTCACCGCTTTGGACATCACAGGTATGGATCTGTTTGGTACAGACCTAGTGGTGTTATCCGCTTGCGAAACGGCCGTAGGTGAGGTCAAGATTGGCCAGGGAGTATATGGACTGCGCCATTCATTTATCATCGCTGGAGCAAGAACTCTCATTGCCAGTTTATGGAAAGTGCCTGATGAGGAAACAAAGGAATTGATGGTGGGTTTTTATCGCAAAATACTCCGTGGTAGTGAAAAAGCGACTGCTCTTAGAGAAACACAACTTGAGATGATTCAGAAACTGCGCGATACAGGCAAGTCGCCTGATCCGTATTTGTGGGGAGCTTTCATCTGTGTAGGTGATCCTGGTAAAATGAATTTGTAGTAATTGACGACAGAAAACGGTTTATCTGTTTTTCTATTGGTAAAAATTACATTGGTAAATCGTCACGGTTTTTATGCGTAGGAGATGCGAAAAAACGTTGCACAAGCATTGGCTCGCATGGGAAAGAAAAATGTCACCATGGATGAAATAACGGTTATAGATGTTCTAAGCATCATTGAGTCTCTTAAAGGAAAGGTTAAACGAACAGATAAGGATTTCGTAAAAGTGAGTGACAAACTCATCCCGGCACTAGTTGAATTTGCAAACGCAAGCAATTGGTATTGGCAATCGCAAACCAATAAAATTTTAGAAAGGCTTACAAATAGAATACTATGGGATGCCTACGAAAATAACGATGTAAAAAAAATATCGCAAAAGTATCTAAAAATATTAGAAAAATCAAATGACAAATCTTATTTAGATACTGTTGCGGCAATTTACGCCTGGCAAAAAAACGAAGAAAAAGCATATCACTATTCGTCCATTGCCTTAGACGAAACGCCCAAAAGAATCAGACTCCTTTTACGAGGTAAAACGCCTCAACAGGTCGAAAAAGAAATAAAAAATGAAAATAAATGATCAACAAAAACGAACGAAAGCCATAAAGTCTGTGGTATTTTGATTGTAGTTGTGGATACACTTAAGGCGCAAATCTATGTACAAAGACGAATACATGCAAAAAAAGCCCATTTATGTCACACTGTCACTTATTGCGATTAGCAGTGTCACTTTTCTTTACAAAATAGAGCTAGAAAACATCTTCTCTGGACAGCGTTTTTTCACTTTAAACTTTAGTTACCTTTCGTGGTGGCATTTTACCATAAATATGCTCCTACTATATATTTTCGGGAAAAAAATCGAAAGTGTCTTTGGCGGGCGATTTTTCCTATGGCAAGTTTTGGTGATCGCTGTGATTTCCCAGACGATGGATTACCTACTTCCTATACACATAAAAACCCAAAGTACACAAGAGGTCGGAGCGGGGATGTCAGGTATTCTTTGTGGACTTTTTGCCTACGCCTGGTTGTGTGGAAAATTTTCATCGCGCATTGGCGTTTCTCGACTATGGGTCATTGCTTTTTTCTTGGTTACTTTGGCATCTCTACCACTACTTTTACAGGGAACTCCTATAACCGGATACTCTCACGTTGCCGCTATTTTTGCTTTTGCCGTAGGAATGTTGTGGGCTTTTTCTCAACAAAGAACATACTTATGTTGGTATGTTTTTGCGTATGTACTGTTGTGGGCATTTATCTGTTTAGCATTACTACTAGCTATCGTTATTTTTTTCCCTCAGTTATTTTACAAAATGAATTTATCAAAAGGAGTTGTCAAAGTACTATTTCTTATGGAAATAGTCGGATTCGTCTTATTGTGTAGACTACCAAGTTGGCGCAATGCATTACCCATGAGACCTCTAGGGCATGTTCACAACCTACGCCCAGTGAAACATCCATCTGCGATTACTCCCACCAAACTACAAAATGACTATAGTACTTTTTGCGTGTTCATTCCTCCCAAAAGGCTCTTTGGACCTGTTAATCGCTATCCATTTTGGGGATTTTTTGGCAAAACAACGTTCACTCTTATGGATGAAGGTATTATTATTGCAGGAAATAAAATACGTGGTGGATTTATCCTCACACTTCTCAGTTTCGCCTTCATCGTTTCTATGTTTCTCCTGCTTGCTCTAACAAAAATCGGTTATTTTTGGATATTTATAATAGCTGTTTTGATCTCTAAGATGATAGAACTCTTGCGCAAAACACAAAGTGAAATAACAGTTCCTTATCCATCTATCATTGCCATGAATTTAAAAAGCGGTAAGCAATTAAAAGTTACTGTGCAAATCAGAAATAAGAAAGTCAAGCAGTCTTTGTTTTTTGAAAAAGAAGAAGCTCTCTGTTTATTTGAAAAAATACGTGAGTTGTTAAAGTAATCACAATATGACGATAGCAAAGAATAGCCCAGTGATTCATTATTAGGAGTTTATAATTGTCAAACCAAAAAATCTGGAAATGTGGGAAATGCGGAGAGGAACACGAATACACATTTGATACCTGCTGGAATTGTGGAGGGAGTATTGCCAACAAGCAAGAAGACCAGACAGTATCAAAAAAATTAGACATCATGGACGAAAATAAACCGGAATATAATGAGTCCATCGGATTTGAAAACTCCTCAGAATCTACAATAGAAGATAGCCATTTATCTCCCATTGAACTAGAAAGTGATTACACTACATATTCGGCTTTTATCCCAACAAAAAGTCTATTTGGGCCAGTTGTACGTTATCCTTTTTGGGGATTTTTTGGCCAAGTACGATTAATGGTGATAGACGAAGGGGTTGTCATTACCGGGCAAAAAATGCGCAGCGGCTTTATATTTCATAGCCTTAGCCTCGCGTTTATTATTGCAATGTTCCTATTGCTGGCTTTAAAGGTTATCGGCCACTTGTGGGTATTTGTTATTGCTGTATCTGGAGCAAAAGCAATAGAAATCATTCGTCAAACGCATAGTGAGATCACCATTCCATTTAACTCTTTCCTGGATATAAGTGGGAAAGGTGTAAAAAAACTTAGGACCGTTGTGCAAATACGCCGTAGAAAAGTTTCTCAAATTTTGATTTTTGACAGCGAAGGCCATGCCGCTGATTTCAGAAATAGAATTTGCAATCCAGGCGCGGCACCAGCAAACAAAAAAACCTGGAAATGTGAGAAGTGTGGGGAAGAGCATGAATACACATTTGATGCCTGCTGGAATTGTGGAAAGGGTATTTCGGAAAATGGCAAAACAAACTCATTGTAAAAAAACAGATATCAGAGAATAAAAAACTAAGATTCACCGCAGTAATTCACAAAAAAGTAAGGGAAACCCTCAGGATGATAAATTGTTTCTCTCTATCTGACCACATTTTTGAGAAACAAAAAGGGAGAGGCAAGTGGATTATTTTTTTTATTCGATAACGACAACCGAAGTCGTTAAAATAATCCATCTACTACAAGAATTCAATCCAATTAAAAAGGGAAAACGATGTTCAAAATATGTATAGCCCTGCTTTTTTTGATGAGTATTTTATATGCTCAGGATATTTGCACGACTCTTGATCACGGAGAAGGGTTTACGGAACAGTCCTTTGAGGAAAAAGAAGGGCTTTCTCTGGTAGGTGTAAAAAAACTATTGTGGCCGGCAAAAGAACGCGTATTACACGTTCGTTTTGTGGGAATCGCCAACAAAGATATTGAGCAACAAATTCCTCAAGCGTGAAGAAGCGAAACACGCGTTAGACTTTATTGATGTCAACACTTCGCGTATTCCCGAGAAAGAGGCCGACTTTGACTATTATCGCGAAATTGCTCAGTACCTAGTTTCGCGGGGAAAGCTACGCGAATGGCTATGTGTTCTTCAACAAGACGGTCTTTCTTTTACCGCTGCGTGGGTTCAAAAAATAGATGAATTACAACAATCGATTGAATTTTCGCAAAAATTAGATCAATGGTCACTACCCGTGCGGTACTGGCGTATCACGATGGGCAAAAACAACACAAAATTTTTCTCATCGCTAAAACCAGAGTGGGTTTTGGCAAAGCGAAAAAATCACAAAACCCCGATGTCGATATCACCATGCGTGTTTTGCCACTGCGTAGCCAGGAACTCGATCCTGGAAACTGGGCGCGCACAAAAAAAATTAGCCAACACCATGGCAATTTTATTCTACGTAACAATCAGTTTTATATCGAGCGTTTGGGAAAAAACGGAATTTTTACTCTAGAGGGAAATGAAATTGAAAAAGAGTCGTTGTTTACATTAAAAGACACAACGCAAATTCGTTTGGCGCAAGAAAGTTTACAACTCAAGTTGAAAACGGTTCGTGATCTGGAAACTCAGAGCGTAAATTGTCTTTGTGTAGAGCGCGTGGATAATCATGTTCACCATTGTTATGTGCAGGTGATTCGTGAGGTGACGATCGGCGTAAAAAAGGCGGATGTCAATTTACCGGGGATGAATGGATTGTTTCGCATTGTTACCGAGCAAGAGGGATGGAATGTCATTCCGGATGAAAGTGGATACACAAAGATAAATAGTGAGGTTATTCAAGAGCCTACTTTGCTTTGTAATCGCGATGTGTTATCAAACGGTCTGCAAGAGATTGTTTTTTGCATGACCGAAGACAATGATTTTGTTGAGTGACGTTTGATTGACACTTTCATTTAAACTTCGAGTACATTTCTTCCACTTCCGATTTTATCAATATTTTGCATAGTACAAAAATTCGAAAGAGAAATTTAAATGATCCGATATTTAGTTCTATTTCTTCCTATTTCATTTTTCATTTACGGTATTTATATTGCTGTTAGAAAAAAAGTTTTTTTACGCTGTTTGTTAGCCGTCTTGCCTATTTCTCTACTAATAATCCCATGGTTTATTCCTGCTCCTTTCCAACGGGAAAACTTTACAACATATGCGGTATACCAAAGGGCACAAATGAATTTTTATGTGCCAATATTTTTATTTTTTTGGTTCCCAAAAATCATAATAGATGTTCTTATCGCAAAAAAAATTGCTCGTTTTTCTCAGAGAAAGGTGTGGCTTTGGGGTTCTTTTGCGGCTATTTCTTGTGGAATTTCTAATGTTATAATGCTCCTACTTCCCAGAAAAGAGGAATATTGGCGTGAAGAACAAATTAAACAAGGGTTGACTAAATGGAAGATTGACTTTCGAGTAATTATACTACTTTTTATTGTTTATTTACCTTTTATTTTATATTTGTTCTTTTTTCCCAAACAAGAATACTATATGGATTTTAAGAACGGTGTGTGGAAACATAGAGAGCTAAAAGATTTTAGGGTATCTCTATTCTCACCTTATTCTGAAAATGAATCTCTAAATCGATGGGAAAAAATTCGCAATCAAGAATGGGAGAAAGAAGTTCAAGTTATTGAGAAGGCTGTAAAATCATATGAAACCAAGTCAACTATTTTGTTAATTCTTTTACACATAGGCAATGCTATTATCGGGGCTTTTTTATCAATCAAAATGTTCCCAAAAAAAGTTAAAGTTGCTTTATGGGGAATGATTGCAAGTACTATCACGTTTGGTATAAGCAATTTTGCTTTAACATTTATTATTTTAGATGATGCCCGTGGTAATAGAAACACTCACGGAATCAGAAATTTGGAACGGTGGCTTTTTTTGTCTATTTTCACTTTTGGATTGAGCAATTTCACCTTTATCTTTTCTCCAAAAAAACTAGAAGGAAAAATACTTTTACAACTGCGCTTACTGAAGAACAAAGCTAGATTATATGCGCGCCAAAATCAGTATACAAAGGCGGAGTTTTTTTACCAAAGAAGTTTGAAAGCTATACAAAATAAAAATCTATATTTTGAAACTGCGGAATTAATGAGTGAAATAGCAATTCTATATCAACAAATGGGAGAATATACGAAAGCAAAGCATTTTCATACCAAAGCAAATAGCACAGTCGAACACCCTAAGGTGTTAAATAAGTACGCTCTGTGGCACGAAGAAAAAGGAGAAAAAAAAGAAGCTGAAGAACTCAGAAATAAAGCCTTTCAAAGCATAAAAAAACAAATCAACAAAGATCCTAAAAATGAATATTTGCATGCAAGCTTAGCAGAAATGTATCAGGATAACAAAAATTACAATCAATCAGAAAAAACTTATCTTCAGGCTATTGAGCTCGCCAAAACAAATTTTTCTCTAATTGAAATATTGAAAAACTTTGCCTTATTTTATGTAGGAATACAACTTTATCCAAGAGCAGAGGATACTTATATAAAACTGATTGAAGAGACACAAACTACATTAGGAACACATAACTCTATTTACATTTCCCTAGTCAGTGATATTGCCTTGCTATCTAAAGAAATGCGAAAGTATAAAGAGTCAGAAGAATTCTTTTGCGAGAATATGCAAGTAATAGAAAACGTTTTGGGAAAAAATCACTTAATTTACATTTTTAACCACATAGAACTGGCAAATTTATACAGTCAAATAGGTGAATATGGAAAAGCCGAACCTATCTATACTGAAATATTAAATATTGTTGAACAAATGAACGAAAAAAATAGCTTTGCATATGCTTCTTGTTTAAACCAAATGGGAAAAATGTATTACAAAATTGATGAATACGACAAGGCCGAAAAATACTATGAGAAAGCAAAGCAAATATACCATGACGTTCTGGGAGAATATCATCCTGAATACAAAGCTTGCCTAATGAATGAGCTAGAGCTATACCAAAAACAAAGAAAATCTCAAGAAGTAAACACGCTAATAAATGAAATCGAATTGTTGAATGAACAACAAAGTTTGTGTGAGTTACCAGAAAACACAGAGGTCGAAAATCTGCAGGTGACCATAAGTTTGGATGTAGATACTTTAAATCTTATTGTAGAGCAAGAAAGACTTAAACAAGCACAGAGAGAACAACAGGTAAACGAGCAGGAAATCATCGCTGCCTTTTTGCAAGGCAGAGAAGAAAATTTTACCAATGCGTTGCAAATGAGTCAAAACGCTATTTTACTGTATAGAAAAAAAGAGTATAAAAAAGCACTTGTACTACAAAAAAAAGCCAGCGAAATTATACAAAAAACACATGGTAAAAATGATCGTTGTTATGTAACCGCACTAAACAACCTCGCTAAGTTATATGACAAAACAGGAAACTATGAAATAGCCTCAGAGCTATTTTCAAAAGCAGTAAATTTACGCGGAAAGATCCTAGGAACAGAACACCCTGATTACGCCACTAGTCTTGAGAACCTTGCCCACCTCCAATATCGTCAGAAGAAGAAACAGTCCGCATTATTCAATATGCTAAAAGCCGCGAATGTACACAATAAAATGATTTTGCGTATATTTTCCATCGGGGATGAAAAGCGCCTGGAGAAATACATTGACACTTTTGAAATACAATATTTTACGCTTCTTTCTATTTTCTATCAGAGCTACAAAGTTTTACACATTTTTTCCCCGCAAGTATGTGATCTTATTTTAAAGCGCAAGTCTTTACATCGCGAACTTACTTCTATCAAACGAGATAGCCTCTTTACGCAACAACGTCCTGATCTAGAAGAAAGTTTTGCAAGGTTAAGGCAAATAAAACTGCAAATAGCGCAACTGATTCTAGCTTCTACCGATGCGTCTTCTACGCAAATTGCAAAACTAGAAGCCGAAAAAGAGCAACTAGAGCGCGTTCTCGCAGCAGAAGTTCCCGAGTTAGAACTCGAAAAGAAGTTAACTCATGTTTCTCACAGAGAAATCGCCAAACTCCTTCCCGCAGATTCCTTACTTGTTGATTTTGTTTGTTTTCGCGAAGTAGATGTAGAGTCTATGAGATACCTCGATGAACGTTACATTGCCATCGTCATCTACAACGAACAAATATCCAAAGAACTCGCCTTTGTCGATTTAGGAGCGGCGAGTGAAATTGATGAACTCATTAGCAAATACAAAAAACAACTGACAACAGGGGAACGAAAAATACATGTTGTTGCGGAAGATGTTTTACCATCAGAAAATACAACCGTAAAAACACAAGATGCATACGGAGAACAACTATTCCAAAAAGTATTTGCCCCTGTTTTACGCAAAACAAAAGACTGCAAACGCCTGATTCTCTCTCCTGATGGCGGATTATGCCTTCTACCATTCGAAGTTTTACCACAACCCGATGAGCGATTTGTGGTTGAGGACTATGAAATCAGTTACATAGATAGCGGCAAAGATCTTTTGCGATTTGGTTATCAAACCGCTCCCAAATCGCAACCTGTTGTTATTGCCAATCCTGATTTTTCTCTGAGTGGCGATCAGAGCTATACGGACATTAGAAACTCCATCCCTCAAAGCATCGTTGCCGAACTGGGACAAACCATTCAACGCAAAGTGCAAGAAACCAAAGCGCAATACTACTTCCCTCCTCTTGCAGCTACTCACAAAGAGGGAGTCACCATTGGTAAGATGTTGCCGCGTGAATACACATCTTTGATGGAAGAAAAAGCACTAGACTCTGCGATTAAAAAATTGCAAGCTCCGCAAATCTTACACTTTGCCACGCATGGCTTTTTCATGGTTGACGAACAACAAAAAGAAACAGATTTAGACGAAATGCAAGATCTAAACGAATCACCCATTTTTCGCGGAGAAAAATTTCGCAATCCATTGCTACGCTCAGGTTTGGCACTAGCCGGTGCCAATACATTTTTTGAAAACAAACAACCCGCACCGGATGCAGAAGATGGCTTGCTCACCGCTTTGGACATCACAGGTATGGATCTGTTTGGCACAGACTTAGTGGTGTTATCCGCTTGCGAAACGGCCGTCGGTGAGGTCAAGATTGGGCAGGGAGTATATGGACTGCGCCATTCATTTATCATCGCTGGGGCAAGAACTCTCATTGCCAGTTTGTGGAAAGTGCCTGATGAAGAAACAAAGGAATTGATGGTGGGCTTTTATCGTAAAATACTCCGTGGTAGTGAAAAAGCGACTGCTCTTCGAGAAACACAACTTGAGATGATTCAGAAACTGCGTGATACAGGCAAGTCGCCTGATCCGTATTTGTGGGGAGCTTTCATCTGTGTAGGTGATCCTGGTAAAATGAATTTGTAGGGACGTAACCGACACGCCGCTTACAAGTATCTAACTAAATAGCTCTTTTTTGAAAATATGATCTATGGATAAAGCGATTTCTGCTTTTGGTGAATAAAAAAGTTCATAAAATCAGTCCAGTCGTCGCTGAGATAAACGCGTAAATCAAGCATAGCTTGCGCGCAAGGATAGACCATACGTAGAATTACAACCTTTTTCCTTTGAAAATTTCGTTTTCTCACTTGGTCTGACATCCATTGGCAAACAGTTTCCGTAGCTTTAATTTCAACACCATTTCCTAGTCGAATACTTTTGCTTCTGATATCCTGTTCATATAGTCTCCTTGATTATTATCATTGAATCGTTCAATGATTTTTTTCTTTTTTGTTACGAGAGCTATTTTTTATTTATCCGCTATTATTTGCAAGATTTTTTTGTTATCCTTTATTTTTACTACGCGGCGTGCCAGTTACGCAAAAAAAAAGAATAAAAAGTAGAGAACAAGTTCTCTACTTACCCATCTGCCAATGAACAATAAGTTATGATAGAGAACAAACACACTAAACAAAACGCCGGAAAATACGGCCTTTGTCGTTAAAATTTCAAAGGAATATCTTTCGTGGTTTTCAAGATACAACTTCGCAGGCTTCTTCGATAAAGTAACCCTAACGTTTCTAGAAGAGGTGTTGTTGTTCGCGAAATAACGCTATCTGGAAAATTTGCATTTCTATTTTTTGGCATTAATCATTTCGACTTGTAAACTATCTTTTACTGATGTTAGGAGTTGTGAAAATGAGATGGAGTCGTATTTTTGCTTTGGGTATTGTTTTTATTTTTATAGCGCTAGCTGATTTACAGATATTTGTTTTCTTTACAGCGCTAATTGCGTTTTCATTTTTATTTTCGTTTTTACAAACGCAATTGGGAATATACTACAAACAAAAAATGAAGAGCGTTAAGCGTTCTCGGGCTAAAAAAGGAAATCACAAGGAACGCATAGTTAAATATTTAGGTTTTATATTTGCCTATGTTGGAGCTGCGATTGTGTTAGATTATTTGGCAAGTCTTACACTATTTGCAGTTGCACTTTTCTACTTTCTCTTTTTTGTGTTTGTGGAAAATGTATTGGTTGCTACTTCTTTTTCAAAAGTATCTACCTCTACGATTTCTAATATAGTGCCACGTAAAAAAGAACAATTTGTTCTTAACGATAAATTGTTGACAGAAGAAATTCTCGAAAATTACCAGGATGAATTACTTGATCATCAAACTTCAGAAAGCCAAGTCACAATAAAAAATTTATATGATGCCCTTGATGACTAAATATTATACATTTGAGAGGTTTTAAATGAGTATTTGGAACTCTATGAAATTTAAACGTTCGTTAATAAAACAAATAAAGCCAGAGAAAAATCAAAAGCCCTCTTTAGGAGAAATTGTAAACACGCTTCGTTGTCTATGGATTCAAAAAGCTAAAGGAGACAAAGTAGTAAAGGAGATAGAAAAAATTCGCTGCCATTATCCTTCGGAAGAAAAGCTAGCAAGTGTAGCAATGGGAGCATATATGTCTGTTTTTCAGAATCAACAATTACTGAATTATGCACTTTCTTTGAAAAACACAGAAGAATTTTTTTTTGAAGGGTATCTATTTCAAATGCGTTACTTGCTTAAAAAAGGCCACGGAATGGTGGCTGTTTTTCCAGTGATGCGTTCGATTCAATCTAATTCATCTCAACAACTACTCAATGGGTGTTTGATATGGTTTTTTGATCGCTATTTCAATACACTTCAGTCAAAAGTAAACGACAAGGAGAATCCCCTTAGTAAAGAAAGATCAGCAATCGCAATGTTTTTGCTAGGGACTTTTGCGCGTTCAGCTAATAAAAAAATTATTCCCAATTTTATAGACGCAGCAGCTAGTTTAGGGAAATCTTGCTCTCATTATATCAAACAGAAGGAAAAACAATTTCAAAAATTGTTTGAGGACTCCTTATATTTTAGCAAAGTTTATGGAATAGAAGCATGGGGCGGACCTGGGTTTATTAAGCGTTGTTATGACCTGACACACATCGGTTCTAAGAATACCATGCAAGAAATGTCCAAACTCATTGCATGGAAACGTGCGAAGGGGGAGGAGTCCGCCAAACTTTCTCGTGATGAAAAAGAGATAGCAAACTACGAGTATAATGCTCAATTGCGCAATTTAAAAACATTGCAAAACCACTTTCAAAAAATGGAACAATCCTATGGAGAGTTTGTACCACTATTAGAGTTTAAAGCAGAACAACTCGCACATTCAGATGCAGAAGGCGCAATTACCATACTCAAAAAGATCATAACACGCCATCCTAATAGAAGTTACTATGCCTATAGAGCAGCACAAATTCTTGAACAGCACAATCGATTGTCTGAAGCACGTCCATACTGGATTCATGCCGCGCGAACTTTAGGAGATGACTGGCGCAATCATTTAGCTAGCATCTATGCCACAACAAAAATGTACACTTTTGAGGCTGAATTGCTGCAAAAAGCTCCACCAACTTTATTAAGCCCGGCAGCTAAAGTTGTGGCTCAACATCTTGAACAGCGACTGCTAAATGCCAATGAATGTTACTACATCACAGCAGCTTATGCTTTGGCAGAGAAAGCAGCGCAGGTATTTCATCTGGCAGCACTACATGCCAGCGATGTTCAAGAACGTGAAGAATTAATAAACCAGGCTTACAAATATTACGAAATGGTTGATAATCCCGAAGGGATGCATATGAAGTATCCTGAACAGGTATTTGAACCCATTGAGATTCCATTTACCATTATACCTGTTTGATGATAGGACTTGAAAACGATGGATAAATTACAAAAAAGTAGTGCAAATTACTACGATATACTAGGAATCTCAGTGGCTGCAGATATAGAACAAATTCGAAAACGTTATCGCATTTTGGCACTAGAGAACCATCCTGACAAATTTCGTATGTCAACGGAGAAACAAAAAGCAAGTGAACGTTTTAAAGCGATTCGCATGGCTTACGACGTTTTATCTAATATAGAAAAACGAAATCAATATGACATTTGCCTTAGAACAGGTAAAGAGTTTACAAATGTACATAACTCTAATGACCCTTTAGAACCAAGCCTTGGAGAGATCCTTTCGGATATTGATCGCTATCAATTTCCACAACAAGCAAGAAATATGAGCGAAGGATTGAAGGAATTTGTGGATAAATCGATCATCCGCTCAGAATCGTTTCAAGAGAAAATTATAGATGTATTATCTATAAAATATAGTGAAGTAGAGACTTCTCCTGTTGCTAGTATCACGGGAGAAGTGGCAGAAGAAAAATTTATATTAACCAACTTACGTTTTATTGTAGCCCGCCAAGGGCGTACTTCTTTTACACAGGGCAAAACTATGTACTCTCAAAGCTCCTATGGTGGCTATGGTAAATTACTGTTAGATATCGAAAAAATTGTGCTGTTGTGGGATGTGAGACGCAATTCAAAAACATTTGATATTGCTTTTTATGGCACAGATCTTCCTTTGTCGGGCATTTACTTCACCATCGCTGGAAGTTTTTTTTCATTTTTGTGGATAGCAGAGTTATACGATATTGAATTCGAATTACAAACTCGTTTTATGCAAAACCCTGATGTTGGTAGAAAGATTTCACAAGGGCTAGCTCTCTTAGGTAGTTCGATGATTTTACTACCGTTTGTTTTACTACCATTCATTTTACCCATGATTTTAAAAGCCCGCTTATATAAATATGTTAGTTCTTTTTGGTGGGAAGTTGCATCACTGTTTATGATTCCGCTAGTGATACATATGTTTTACAGCAGAAAATACAAACAACAGGCTGATATATCTGAATTTATTCATAAGTGGTTGCCTACCCCCCCCAAATGAAAAGTTCTCTCTGAATAGAAAACTATTTGGTTTTTTGTGATTTCAAAACTAAAATAAGTAAATTATTTTTAAAAAATTCAAATTTATGAGGTTGTACATGAATTCACAAACAATGATTACTTCTCTTGCCCAACAATGTATAGATCATTATCTGACACCAGAACAAGTCGATTTTGTTTTGCAAAAAGTCGATGTCAACCCTTTGGAAATCAAAAAATCTGCAGAAACGCGGGTGTATTACACCCATATTATTCGTTATCTTGCTCCTAGAAAAAAACTCGATGAGTGGTTGATTGGTTTGGAAGAAGAAGGTTTTGTATTTACCAAAGACTGGATCGGCAAAATACGTGGCGATGATATACCAATGCATGATACAGAACAAAAACCTAAAAAAGATCCAGCGCTAGCAGAAGCAGAAGAGGGACTACGAATTCTACAGATGCTGAAGAAAAAGAAAGGAAAATAGAATGGCGCAGGCAATAGGTATTGATTTGGGAACGACAAATTCTGTGGTGTCATTTTTACGAGGTGGCAAACCAGAAATTATTCCCAATCGTTTTGGCAAAAACATCACTCCTTCAGCGGTGTTTCTTCCAGATTCAGATAGTGTAATCGTTGGAGAGCCGGCAAAAAGTCGCGCAGAGCAATATGCAGATAAAACGTTTATTTCAGTAAAAAGACGCATGGGGACAAACTATCGTCGCACAGTGAACGACAAAGAATACGCACCAGAAGAAATTTCAGCGATGATTTTGCGTACTCTGAAAAAAGATGCCGAGGAATTCCTTGGCGAAGAGGTAACACAAGCAGTGGTAACTGTTCCGGCGAATTTTAACAGCACAGAGCGCCAGGCAACAAAAATTGCAGGAGAAATCGCTGGGCTAGAAGTATTACGTGTTGTCAATGAACCTACAGCAGCAGCGCTTGCTTACGGACATCTAAACCAACTTTCCCAGATTGTGCTTGTTTTTGATTTAGGAGGTGGAACATTTGACATATCCGTCGTCTTTGCCGAGGGGAATATGTATGACGTACTGTTTAGTCTGGGAGATAACCGTTTAGGTGGTGACGATTTCAATATGCATTTTCTCGGATATCTGGTCGATCACTTAAAAAAAGAACATGGCTTGGATGTTTCAGGTGATAAAAATTTACTGCGCAAGGTGCGTCAGGAAGCAGTAAAAGCAAAGCACAATTTGACAAAAAGAGAAACGGCACGCATTTATATACCTGAAATTGGTACCAGCGGTGGCAAAAGAGTTGATCTTGATTTGACAATAAATCGAGAAAAATTTAAAGAAATTGTACAACCTCTATTAGAGCGTATCAAACAGTATGCACACAAAGTTGTGGAAGAACTAAAACAACCCAAGTATACCCAACGCTACGCAGATTTCCTAGGGGAAAAACTTGAGAAATGCGATGTCATTCTTGTAGGAGGAGAAAGTCGCGTTATTGCGGTGCAGGAGACTCTTGCCCAGGAGTTTCATGGACGCATGTTCAGCAACATAAATCCTGATGAAGTCGTTGCTATGGGAGCAGCGGTGCAAGCGGGTATTTTAACTCATCACTCTGATGTACGTGACATAGTTCTAGTAGATAGTACCTCTTTATCCTTAGGTACTGAAGTTGTCGGTGGAGGTTTTTCTGTGATTGTTCCAGCAAATACACCTCTACCTGTAACTCGTACACAAGACTATTATACCGTACATGATAATCAAACATCGGTCAACGTTGGGGTATACCAGGGGGAAAGCTCTATTGCAAAGCAGAACAAATTACTAGGTGAATTTGGCTTAAATGGCGTCCCACCTCGACCATCGGGGCAAGTTCCTATTTTGTTAACATATGATCTAGACGCAAATGATATCTTACATGTAGAAGCACGCGATAAAGAAACAGGGAGACGTGCGGAAATTACCATAAAAGGTAGTCAGACAATACCACAACAAGAAGTTGAACGTATGAAACAAGAAGCGGCACAAATGGAACAGCAAAATGTGGAGACTTTGCGCGTTAATCGCTTACGCGAAAAAGCTGAATCACTTATCCAGGAAAGCAAGGCAATTCAAAATATGCTTTCAAGTGTTGTTCACCCAGACTATCTAGAAAAACTAGACAATGCTATAAAAGCAATTCAGGCAGCATTAAGAAAAAGCGATGTCGAAGAAATAGATCGTTGCTTTTACGATTTATATCATCTCATTCCAGATGAAAACGCCCAGGAACCAAGTATATCTATGAACGTAGACTCGTGTGGCGGATTTCGCGCAAATGAGTGGGGACGTCTGGAAATACGCCTTTTAAATCAGGGGCAGGGAGCAGCCCTGCAAGTTCAAGTTACTATTAGTGGGGCAACAAAAGAAAAGCAAACGGGAGCAGTTGCTGCTGTCTATCCGGGAAGCTCGCAAATCATTCCTCTTTCGATTTGTCCAGTTAACCCAGGCAATGCAGTGCCGATATCAATTATGGTGGAATACCAAGACGAAGCGGGCATTCCTTTTTTAGTAAAACAAGAGGCTTCACTAGAAGTGGCTTATGCGGACCAACCAATTTCCAACGCAACAAAAACAGTAATTAGTATTGGGGAAATTATCAACCATACCGGTGTTGGTAATGTACAATCGCGCCAGCAAGTATCAGGTGACAATGTAGTGGGAAGCAAGGTAGGAGACATTGTAGCAACGCGTTCTAATGTAAGTATTGGCAATGAAACTACCCCTAGCATGGCCACAGAAGATACAAAAATGTCATCTCCAAAACAACAGGAAACTATTTGTGGGAAATGTCAGGCTTTTGTACCGTCTGGTTTTGCTTTTTGCGGAAAATGCGGTAGCAAACTAGCGTTGACGTGTAGCAATTGCGGCAGTGAAATACCAGATGGATTTCAGTTCTGTGGGAAATGTGGGACAAAGGTGGGAAGCTAAAATGGAAAAAATCAACGGCAAGCGCGTAAAGTGGCTACAACAAATAGACAATACCGCTAAACCAATGCCTGTAGATAACGGATCTATTTGGCACAAAGAACTCTACGGTCTCCTATTTTTTGACGATCATATCTCTCTCGTAGATTGCGAAGGAAAACAAGGAGTTATTCCGTTTATCGACATCATGTTGGCAAAAATCACAGAGGATGTAGAAAACCGCTATTTGATTACGCTAGAGTTGCGCGAAGAACAACAAAATATGCCCAAATTCATTTTGCAATCACAACTATTTTTTTTACTGTTTTATTCTACTATGCAACAGCATAAAGTTCCTTTTCACTTTGATTTTACCCCGGCACGTCTGCAGGCGTTGGGAGCGGATAATTCTTAGTCGTCGGGTGATTATAAACATTGTAATGAGCTTAAAATTTACATATGTCATTATTGCCAATGTTTATGCTACAGCAAAGAACTATACACTTGACTACCAAGTCGGCACAATGCATTACCCATGAAACCTCTAGGGCATGTTCACAACCTACATCCAGTGAAACATTCATCTGAGATTACTCCCACCAAACTACAAAATGACTATAGTATTTTTTGCGTGTTCATTCCTCCCAAAAGGCTCTTTGGACCTGTTAATCGCTATCCATTTTGGGGTTTTTTTGGCAAAACAACGTTCACTCTTATGGATGAAGGTATTGTTATTGCAGGAAATAAAATACGTGGTGGATTTATCCTCACACTTCTCAGTTTCGCCTTCATCGTTTCTATGTTTCTCCTGCTTGCTCTAACAAAAATCGGTTATTTGTGGATATTTATAATAGCAGTTTTGATCTCTAAGATGATAGAACTCTTGCGCAAAACACAAAGTGAAATAACAGCTCCTTATCCATCCATCATTGCCATGAATTTAAAAAACGGTAAGCAATTAAAAGTTACTGTGCAAATCAGAAATAAGAAAGTCAAGCAGTCCTTGTTTTTTGAAAAAGAAGAAGCTCTCTGTTTATTTGAAAAAATACGCGAGTTGTTAAAGTAATAGCGGTATGACGATAGCAAAGAATAGCCCGTGATTCATTATTAGGAGTTTATAATTGTCAAATCAAAAAATCTGGAAATGTGGGAAATGCGGAGAGGAACACGAATACACATTTGATACCTGCTGGAATTGTGGAAAGGGTATTTCGGAAAATGGCAAAACAAACTCATTGTAAAAAAACAGATATCAGAGAATAAAAAACTAAGATTCACCGCAGTAATTCACAAAAAAGTAAGGGAAACCCTCAGGATGATAAATTGTTTCTCTCTATCTGACCACATTTTTGAGAAACAAAAAGGGAGAGGCAAGTGGATTATTTTTTTTATTCGATAACGACAACCGAAGTCGTTAAAATAATCCATCTACTACAAGAATTCAATCCAATTAAAAAGGGAAAACGATGTTCAAAATATGTATAGCCCTGCTTTTTTTGATGAGTATTTCATATGCTCAGGATATTTGCACGACTCTCGATTCAGGAGAAGGGTTTACCGAGCAGTCCTTTGAGGAAAAAGAAGGGCTTTCTCTGGTAGGTGTAAAAAAACTATTGTGGCCGGCGAAAGAGCGCGTATTACACGTTCGTTTTGTGGGAATTGATGACGACAATATTAAACAACAAATCCAAGAAATTGTTGAGGACAATTGGGAAAAGTGTTGTGGGATTGATTTTCGTTTTGACAATCATCCCAAGGCGCAAATAACGGTCAATATTATGGCCGGAACCAAAAACAATTCATTTGTTGGTACCGATTCGAAAAAAAAAGTTCCGAGCATGAACCTTTCTTTTTATAAGTTAGATAGTGACGGGAATGCGTATTTACCAAAAGACTTCTTTGAGATCGTTGATGGTAAAAAAAAGATTCGCAAAGGAAGTTATGAGTATGGAACCATTCTTCATGAATTTGGCCATGCCATGGGGTTTATGCATGAGCAAATGAGTCCACATTTTGACGTAAAGTGGGACAAAGACAAAGTTTTTTCATATTACAGAAAAAATGGGCCACGAGAATGGACCGATAAAGAAGTGAGAGATTATGTATATCGTAATGTACTAAACAAGCAAGAATATACGCGCATAGCTCGTAGAGTGGTCACATATGAAACAGAATGGATCTTTGGATTTATACCAAGAAGAACAAAAAAAATAGATATGCGTAGTATTTTTGTTCCCCGATATACCGCGAGCGAATTTGATCAACATTCTATTATGTGCTATCCCTTAATGTTAGAACTGGCACAAGAGAGTAAGGAACTCCGCTTGGGAACTTTAAATATCAAATACAAAAAATATTTAAAGGCCAAAGATTACAAAAGTTTGCACAAAGTTCTGTCAAAGCAAAAAAATATTGACGTAGATACCAAAGCAACAATTACTGGTCGCAATGGACCTTGGCACTTGTACACGACTCTTCCTACAAATAGTAAACTAAAATCCTCGGCCAAAGTACCCAAAAAAGCGTATCGCATTGTGGAAGCCAATGGCGTTTTGGAGATATACCCCGCCATAGGTGGTGGGCGTACTCTTTCGGTGATGGACCGTTATTTTTCCAACAAACTTTATCCCTTCCCAACGAAATCGCAAACACATAATTTTGCTGTGCGCGAGGTGAATCGCGCTTTTGATGAAATCTTGTTACGTCAACCGACAGCGGATGAACGATCCCACTATGTCGACTACATGAAGAAAAACAATTTGCTCAAACTGCGCGATCAGGTAGCGAATTTAGCCGAAGGAAAAATCAAGAAGTTGTACTTTTCTCTTGCTGGTCGCGAGCCAAGTCAAGAAGAGATGAACAGCGACAAAAGATTACTGGCCATGAAAGATTTTACTAGCTTGGAAGCAAGTGCTTCTCTAGAGGTAAACTTGCGTTCGCGAGAACAATTTGGTAATGTCGCGCAATTGGAAGTTATTGGACTTTACAGTGTTCACGCTGGAGGAAGTTTTTACGTAGATAACCACGAAACCGTAGAGTTTCGTGCAGGCGAGGAGATACTTCTTCAGGAGGGTTTTACTGCCAAGGCGGGAAGCGATTTTACCGCAAAATTGTATAGTAACGAATAGTTTTTTAGATATCGAGAAATAAAAATTTTTTACATATTTATATAAAACAACAGAAAGGAATTTTATGAATAAGTGCCTCTTGCTTTTACTACTTATGGGGAGTTTGGCATTTGCCGATGTACTTAAACTAGGTGGAGAGTCCACAAATTACTACCCTGTTTATTTTGAATCCACTGATGCACCAAACACTCTACGTCTTGGAAGCTACAAAAATTTTGGTGGCGGAAAAGTAGAGTCTTTGGACGCCAAATTCCAGTGGCGTGCAAATAGATATGGCTGGGTAAAATTTGAAGAAGCGCGGATCCATCAAGAAATAGGGGTATTCATCGCTGGCTACAGTGCAGATATTAACAAATCTCAATATCATGGGATTGTTCTGTGGTTAAGAGGCAACACGCAATATGATCATACTTCAGCGAAAGTTATGAATACAAGCAAAGAATACAAAGATAGTAAAGGGAATCAGATCAGAGAAGTTGCCGGAGGAAATCTGACACTATCCACAAAAACGTTTAGCATTAAAAAACAGACACAAGTAGACCCATACGTAGGCAAAGCAGGAAACTTGTATCCAAAGAACGTTGTTGTTGGCGGCGATACTTTTGTAAAAGGCCGTGTGGGAATTGGGACCTATGCCCCGTCAGTAAACTTACATGTGGAAGGAAAAACGTTTATACGTGCGAGTTCTACAGGTCTATTGGAGATGGAAAGCTTGTCTGGGGAAACCGATATCCAATTCCGCGATCCCAAAAACAACCAAAGCTGGCAGGTGGGAAGCAACAGCACTGGTTTTTTTATTCACGATGACAAAGCTTCGAAGTACCGTTTCAATATAAACAGAAACGGTAATATCGGAGTCAACATCAAAAATCCTACCGCCAAACTAGACGTTGTTGGTAGTTTCCGTGTGGGAAGTAACAGTGAACATGTTTTTCAGGTAACAGATGACGATGCCAAAAATCAAATGCTTCTCAGCACTTCACAAAGAACACAAAATAAAACTCCACGAAATATCCACTTTCGCAGTTTCGGCAACAACGCCAAAGCCAATGTTCTTTTTATGAATATGTCTTCTGGGCGTGTCGGTATTGGTACAGATAATCCATCCGTGAATTTGCATGTAGAAGGAAAAACATTTATACGCGCAAGCTCTACAGGTCTATTGGAGATGGAAAGTTTGTCTGGGGAAACCGATATCCAATTTCGCGATCCTAAAAACAACCAAAGCTGGCAGGTGGGAAGCAACAGTACTGGTTTTTTTATCCACGATGACAAAGTTGCTAAGTATCGTTTCAATATCAATAAAAGTGGTTATGTTGGAATTCATACAACTAAACCAACAACTCACCTAGATATCGTTGGTAATTTGCGTGTAGGTAGTGATAACGAACATGTTTTTCAGGTGAGTGATGACAGCGCAAAGAATCAATTGGTTTTGAGCACTTCACAAAGAACACAAAATAAAACTCCACGAAATATCCAATTTCGCAGTTTCGGCAACAACGCCAAAGCCAATGTTCTTTTTATGAATATGTCTTCTGGACGTGTTGGTATTGGTACGACAAATCCATCTGCTACATTGGACGTGAATGGCAATATAATCACTAGCGGCTACGTTCATACACAAGGCAAAGATGTATATTTTCATAGCAAAATTACTGATATGAACCATGGTATAGGTATGTATTATGACACTAAGAAATTCGCCAATATAAATGTAAACGGACCTGTGGTTTATGGTTGGTGGGGTGGTGCACTTGGTAGTACCGAAGGCGGAAAGAAAATTGCCTTGCGTTGGGACCAAAACCAGAATGTTTCGATGAATAAAAATCTAAGTGTTGCAGGCAATGCCAACATCATGGGAAATCTAGATGTTTCTGGCACGGTAAAAGCGAAAACGTTGCAAATCGACAACGAAGGTTGGGTCGGACTCAATATGACTCCGGAAAAAGGCTACACGTTATCCATCAATGGTAGTGCGCAAATCAGAGGCAAGGTAGTTACTCGAGGCCATGTTCATACCCAGGGCCACGATGTCTACTTCCATAGCAACAGTGCCGACTTCGCTCATGGTATAGGTATGTACCACGACACTAAAAAGTTTGCCAATGTAAATGTGAACGGACCTGTGGTTTATGGCTACTATGGAGGTGCACTTGGTAGTACCGAAGGCGGACAGAAAATTGCTCTTCGATGGGACAAAAACGGCAATGTGGGAATCGGAGTTATAAATACCCAAGGTTCTAAACTCGCTGTTAAAGGTAAAATTACTGCTCAGGAAGTGCGTATCATCAATATGAAAGACTGGGCGGACTTTGTGTTTGCCGATGACTATGAACTTTTACCAATGGACGAACTAGAACAATCGATTAAAAAGCACAAGCATTTACCGGGCATTCCTTCGCAACAAGAAGTAAAAGAAAAAGGAATTCAGCTGGGAGAAATGCAGGCAAAGTTATTGCAAAAAATCGAAGAACTTACTCTGTATACAATTGAGCAAAACAAGAGGTTACAGGCGCAACAAAAGCAAATTCAAGAACTAAAAAAACTTATACAATTGCAACAAATAAAATAATGACGTCGTTTACCGTCCCTATCCATTTCCTTCTCCTATCTATGTCTATTGATTTTGCGATGAAAAGGGAGAGGGATGCGGATAGGATGGGATAAGAGCAAGTATTAATATAAATTTGTTATCTACATATCAGAAAAACACTCAAAGAAACAGGAGCAAAAAATGAAAAGAGTGCTTTACTTGGTCATATTTTTTTTACCCGCGATTGCTTTTTCTCAAGATGGCTTAGTGGGAAAAAAACTCCTCATTCAAGGTACAGATGCAGATAATTTTTTTAAGATAAGGTTTATTGGTACAAAACCGTTCATCGAAACTTCCTTCGACTCCGAATTTGTAATTCATGCAAAAGTACAAAAAGATAATGATAATAGCCCTATATTCCAATTTGTTGGTATCGCCAATGGTGGCCAGGTAAAAAAACGAAGTCTTTTTCGCGTTACAAACAATGGTCATGAAGCAATGGAAATAAAAGCAGACGGTCACATTTTTTCTCAAAAACTGGCATTAGGAACAAAAAATCCAACTCAACGCCTTCATGTGGAGGGCGGAGCATACATTAAAAACTATCTGGTGACTCCACAAATAAAAAGCGACGAGATCGGTACTTTAAGCATAGATATAGATTCGAAAAAAAGAAAAATCAGTTTCTTTCACCAAAACACTGTTCTCGCCGATGTGTTATCTGCTGATGTAAATACTGTTCTTCTGCGCGTAGGTGGCTATGAAAGTATTGGTCGTTCGCAAGTAGGTAAAATAATCAGTACCGATTTTCAACTTATTCCTCCTGATACAGAAAAATTTACCAATACCCTTTCCAAAGTATATTGGAAAGATAAAGAAGAAAAGATCGTGATGACTTTAGGTGGCGGTTCTGCCAGCGAAAAATATGTCGAGCTAAACGCAACGCGTGATCTCTATATCAATACCAAGGTAGGAATTGGTATAAAAAATCCTGCTGAAAAACTCCATGTAAATGGTGCAGCAAAGTTCAATCGCGTCATCATAGGTGAAACAATTTTTTCACGCTCATTTGATAATGTACAACAATTCAAAATAGACAATGCAAAGGGAAATATAGAAATTGCAAGCAATTATCTGCATCTATCTACTCCAAATATACACATAAGCGGAACAATAACGAATATGCTCCATGTTAAAGAAGGTATTCATACTCAAGGAAAAGACATCTACCTGGGCGCAAATAACACAGATACCAATCACGGAATTGGGATGTACCATGGTAAATATGGTAATCATGAAGAAAAACTATTTGCCAAAACCAACGTAGACGGCCCGGTGGTGTACGGATATAATGGTGGTGCACTTGGTACTAAGCAAGAAGGAGAAAGAATAGCTTTACACTGGAACAAAGATCGCGTGCAAATTTATAAGAAGTTAGATGTGGGAAGTGGCGCCAGTATACAAGAAAACGGTAACGTTTATCTAAAAGGTAATGTTGGAATCGGAGTTACAAATACGCAAGGTTCTAAACTCGCTGTTAAAGGTAAAATCGTAGCGGAAGAGATACGCGTGATTAACATGGAAGACTGGGCGGATTTTGTTTTTGCCGAGAACTACGAGTTGTTGCCAATTCAAGAGCTCGAAAAGTCTATCAAAAATAACAAGCACTTGCCTGGGATTCCTTCGGAAAAAGAAGTAAAAGAACAGGGAATTCAGTTAGGTGAAATGCAGGCAAAACTGTTGCAAAAAATTGAAGAATTGACATTGTATACCATTCAGCAAAACAAGCAGATCCAAAGTTTGCAGCAGAAAAACCAGCATCTGCAACAAGAGATGTTACAAATTAAAAAACTTTTGCAACATAAGTAACGAAGACTGTCATTCATCAAAAATCTTGTCAGCCCTGCATGTGCAGGGCTGTTTTTTTTGGCGATGTTTTCTGCGTTGTTTGGCATAACTCTCGTACCATTGGGCAAAATTTTTTTATATGCGAAGTCACCGTCGTATTGAAAAATAAACCCACGACAATCTACATGCCAAAGGAGAAATCATGTCATACATCGCCAAATACGAAGATCTCATGTCACAAACATTCTATGTAGATAGCCAGAGTGAAATTCTCTTACTAGAACAAGCTGCGCGTCTTGCAGATAGCCACAACGATATTGATCTTGGATTTCGTGCACGCCGACGCATGCTGAGCATAACAGAAATCACAGCTTATGTCGACAAAATGCTTGCCGCCTATGCATGGTGTCTCACACAGTGCGATCAACTACCCGATATATACAACGATCGTGATTTATTGTGGTCCTTTAAGTGGTTGGTGTATTCACTACCAGAATGTAGTTACATCAACAAAAAACAAATACACTCGATCATCAACGATATGGAACAACGCTGGCAAAAGTATCAACTCAGCATGCACACGATTCACTACATGCGCTACATAGTAGCCGTGACCATGGCTGATCGCGAAACAGCGAAAAAATACTATGCTCTATGCCAACAAACATCGCGTGGCGAATATAGCGATTGCTCAAGCTGTGAACATTACAACTCCGTGCGTTATCGCGTATTTATGGAAGAATACGGCCAGGCATTTGCCGAAGCGAAAAAAATTCTAGACCAAGAACATTCGTGGTGGGGATGCTCGGAAGCACCAGCACTAACACCAGGAGAACTCATTATACCTGCGTTGAAGTTGGGCAAGATAAAAGAAGCGCAAAAATATCATCAATTGGGTTATGAGAATGTTTACGGAAACAGACGCTTTTTCGAAACACTGGCACAACATTTTATGTATCTAATTTACCAAAAAGATGACGCAGAATGCCGAAAGCTGTTTGATAAACACATTCCTATTGCTTTTGGGATACACAACGACTTTTATTGCTTCCAGTTTTACCTTGCCGCCACTTGTTTTTTTAGCAACACTAACAAAGATCGAATTAATGTATCTATGCCGAAAAACTTTATCCTCCACAACCCAGAGCAGATATACGGTGTTTCGGATTTGAAGTACTGGTTTATGAAGAAAACACGCGACTTGGCGGTCGCTTTTGACGAACGCAATGGCAATGATTACTACCAACGTGAAATGAATGTGCTTATGGAGTTGTTAATTGATTGAATTTCGTAGCAAGAGCCATAGCTTCTTGCTACGACTCTTGCTTTTATTACAAAACTATCTTGGTGCATTCTCTAGATTTCGATTCAAATGAGAAAGGGAAGGTTGAAAACGGTATAGAAGAATAAAGAATGCGATCTGCACAAAATAGTTTATCAACCATAAAACTTCTAAATTAAGTTGTATTGCTATTACAGTAAAAAAAGTATATAGCAAAGCGATAATTAAGATTTTGTTAAAGTAGTAACGACTTTGTTCCCAAGAAACGTACAAAATACCAAGGAAAAAACCAATAAAAATTCCCCAGTACAGACCGATCAACATATAAATAGTAAATGTAGTCTGGACGGCCCATGGAAACTCACGAATGCCATTTTCTAGAGAAAAAATTGCCATGAATTCACTAGCAAAAAGGAAAAATATAAAAAAAATCATTAGTGGTTTACTGATACAAAAACTTGGATGGAAGGTATACTTACCGTACATCCATATATAAGCAAATAAACCATAGTTTATTGCCACCAATTCCCTAGGACTATTATCAAAAAACAATACCTGTACTACATTTGCAGAAAGTCCAAAAATCAAAATTAACTTCATCAAATACAAAGAACCATGTAGTCGTTCCACTTTTTTAGCTAGCACCAGAAAAATAGACGTGTGGCATAAAAAACTTATCCAGTTAAGATGTACAAATATTGTGGTTACAAGAATCCATACTTTACCTGACAGCAACAATGCAAAGTTGCTTATACGCTCTTCTCCGAAAAACATGTAGGGCCATGTTAGAAATTCATGAGGTATACAAAAGTAGTCTGGAAGTTTATGGAGTATACTAAAGTAGTCTAGAGTAAAAGGAAGAAAACTAAGAATACACAGAGCGACAACGCCATAAGTTACTCGTGCCGGATTGTGTTCCGTAGATAAATAAAAATCCTTTGTATTGGTGTGAAGAGATGCTTTTTCTGTCAGAGTAGAACAAAAGTCTCGAGCATCAGAAATGGTTTGAAAGGTAAATTTTTGTATTACCCTTTTATCTTTAATTGATACAGCAATACCGAGATATCTTTTTTTATTTGGGCTTGTAACAGCGATGATAGAAGTAAATGGAATGGTAATTTCACTATTAACTTTTCGAATTTCTTCCATTCCTTTTATACCAGATAAAGCTAGAAAGAAAACGATAAAAATGCCCATAGTCTTTACCAATAGCAACAAGAATATAGCGACTATAAATAACATTGTGATAAAAAAAAACACAAAGCCACCACGCATTTTTTTTCCAATAACAACTATCCCTTCATCCACAATTTCTATTTTAGCTTTTCCAAAAAAACCCCAAAATGGATAACGGCGAAAAGGACCAAAAAGTCTTTCGGGAGGAATTCCAATATTGTAAGTTTTTCGTTCAGAAACTAATTCAATAAGTACGGTGTCAAAAGAAACTTGCTTTTTGTGCTGAGTTGGTTTGTAAATAGGCGCCCCGCAACTCATGCACTCTTCATCTTCAGGTAAAATTTTATTAAATCCGCAATCGCCGCAAATATTTGTTAAGTGAGAAGGTGACGCCCCTGATAATTCACTTTTCATAAAATTTACATCCTAACTCTGGTCATCCATTAGAAATCCACTCAAATTTTGACAACCTCGCGACCACTTTTTTCGTTAAAGTTCAATTGTAAAATTCAAAGGAGAGCGTTCTTTCAAATTCATTGTTGAATCACAATAAACATTTGCAAAAAAAACATGCGGTAGCGCAGTATAAACTTACACCGCGCTACCGCACAAATCCCAATTTTGAACTGTTTTCGTCCAGTATGTACCGTTTTTACACCAGCCAGGTAATTGGCAGACGCCATTTAACCAATCATTTTCTTTTTCGTTGAGATGAATCCAGGTATTGTTCCCTTTACGACTGATTCTCACTACCTCACGACCGCTTTTTTCGTTAAATGTCAACTGCATAGAAAAATTTTTTTTGATACAAGCAAGTAATACCTTCACTTGTTGCTCCAAAACGGTTAATTTAGTAGAAACGTCCCCCACCGCAGATAATACACGAGCGTTTTCTCGAACATTTTCTGATGTGACATTGTATTTTGCGAGAACTTTTTTGTATGCTGCGCGAGTGATAGTGATCTCTTCGCCGTATTGTGTCCAGTAACCATTGTAGTAGTAGATATGATCTTCGGCGCCAACAGAACGAATCACTTTTTCAGGTTCCATACCTTCATTTCGATAGGCAAACACAATTAATTTGTCTATCAATGTTATATTTGGGTTAGAAAAAAAATCCATGTTGGGCTTCCTTTTCAAGTAAGATTTTGTGTTGTCATTTGCTTTTCAATACGACGCTGCTTTACCGAGAATTATGACAAAACAAATGTTCCCTAAAATTATATACCACACTACCATAATTTACGGTTACTTTTGGTCTAAATAGATCTATCGTTGCGCCACTGGGAATAATAAAAAGGAGTTACTTTGCTTTATATCAAATCACCGAGAAAAGTAAAACGAATTGTTAGAACACAACAGTTGCAACTATTCTCGGTGATTGAGGTTTTATAACAAGGAGTTACTTAAATTATTTTTGGTTTATCATTCTCAGCAAAGAATCCAATTTTTGTTGCAAGACATCTATTTTTTGTTCATTTTGTTGCATTTTCGCCACCTTGCTTTCTAACGTATTCTTTTGTTGCTGTAACGTTGTGATTTTCTTTTCTTGTTGAATGGTATAAAGTGTGAGTTCTTCTATTTTTTGCAACAACTTCGCCTGCATTTCTCCTAACTGAATTCCCTGTTCTTTTACTTCTCTTTCTGATGGAATGTTCGGTAGATGTTTGTTGCGTTTAATGGACTGTTCAAGTTCGTTAATCGGCAAAAGTTTATAATCATCAGCGAAGACAAAATCCGCCCATTTTTTCATGTTAATGACACGTATCTCTTCCGCGGTAATTTTTCCTTTAACAGCGAGTTTAGAACCTTGTGTATTCATAACTCCGATACCCACATTGCCATCTTTGTCCCATCGAAGAGCAATTTTTTGTCCACCATCGGTACTTCCCAGTGCGCCACCAGACCAGCCATAAACAACAGGTCCATTCACATTTGTATTGGCAAACTTCCTGGTGTCGTGATACATACCGATCCCATGAGCCAAATCATTACTGTCATTATGAAAGTAGACATCGTTGCCCTGGGTGTGAACATGGCTTCGGGTAATTATCTTGCCTTTGATTTGTGCATTGCCATTGATGGATAATGTGTAGCCTTTTTCCGGAGCCATATTGAGTCCAACCCAACCTTCTTTATCTATATGTAGGCTTTTCGCATCAAAATTCTCGGTTATATTGAGACTTTTTGCTGATACATGATTGGCATGTAAGGTTTTCTCCACGGTTAAATTTCCTTTGATGGAAACATTTTGGTTTTGGTCCCAACGCAAAGCAATTTTTTCCCCGCCATCTTTACTCCCAAGGGCACCCCCTGACCATCCATAAGCAACGGGACCATCTATATTTTCTCCAGCGAAAAGTTTGGCAGGATAATTTTCATTACCATGGTTGTACGCTGCACGGTATAAACCTATACCATGGCCATTATTTGTATGGTTATAGTCAAAATATATGTCTTTGCCACCGGTGTGTACACCAGCTGTTGTCTGAAGTCTACCATTTATAGAGACATTTTTGAGTATTAGTAATTCACTATTGATTTGAACCTTTGGGGTCGTGGATGCTCCCGACATTTCAATAAACGTATGTTTATCTAATGACTTTAATCTAAATCGACCACCATTAATATCAATAGCATATTTACTTTCTTCGCCAAAGACTAATCGCGGGACACTGCCACCAAGATGTAATGTCCCTTCAGGATTTTTTGTATTAATTCCGATATTACCATTTTTGTTCAAGTTAAAACGGTATTTCGCAGCTTTGTCATCATAAATATAAAAACCGTTTTTATTGCTTCCTACCTGCCAGCTTTGATTATTTTTGGGGTCGCGAAACTTAATATCAGTTTCCCCAGAAAGACTTTCTATCTCCAATAGGCTTGTGGAACTAGCTCGTATAAGAGCTGTACCTTGTAAATGCAAACCCGCAGATGGATTTGTAGTGCCAATACCTACATTCCCCTTAGTCCATATCCCGGTATTATTTAAGCGAAAATTTGGAGCCGATATGTCTAAAAAATCCCCCCCCTGATTATCCCCGTTAATTCTTATGGCTGCCGTGTTACCTATGTTAATAACTTTGCTATTGATTTGATCAATGGTTCTCCCCTTGTTAACGTATTCTTTTACTTTATCTAGGGGATAGTACTGTTCTTTTGGTGAAGTCTTGATGATTAGCGGTTTTTCCATATTACTCCCACTATTATATATGGCTCTTGACTTCCCGCGACCAGCAGCAAAACTGAAAGAGTATTTTGTACCTCCGCGCAACCATACGATGAGTCCTTTGTGGTGCTTGGCATATGTATAACCAGCGATAAAGTTAGAGGCCAAGTTTGCGTTGGTGGTTTTGTTCGGGATGTAGTAATGAATATCCGCTTCAGCAAAAGAAGTAGAAGATCCATTCAGGCGATCACCATGTGAACGAAATTTCGCAATTAGAGTTCCATGCCAAGTGGTTCCATCATGAACTTGACGATAAATATGAACATCAAATGCCCCTCGTGCCCAGGCATCATCGTAAAAAAATACAGGGTAGTACTTTTTTGCACTTCCACCAAGTGTCAATTCAGCTGCAAATATAAACGAATATAGGCAGAATAATAAAACAACTATTTTACGCATTATTTTCCTTTCTGAAGTTCTATTGTACTGTGAAGATTGATTTACTTATTTTTGACAGCACTTTCTAATTTTTCAATCCGTCTTAGCAATTTGTTTTCCATTTTTATTTTTTCTTTACTCATTTGCTGTATTTTCTTTTCTTGCTCGATGGTGTACAAAGTCAGTTCTTCTATTTTTTGCAATAACTTTGCCTGCATTTCTCCCAACAGAATTCCCTTTTCTTTCACTTCTCTCTCTGATGGAATGTCAGGTAAATGCCTATTGCGCTTAACGGATTTGAGGGCGTCTTACATCATGAATAAACGAACCACAGAGCACGCAGAGAAATTTGTTAAAAAACCTAAGGATTGTCATATTTTTGTTGCTTTATAATTCGTTCTGTAATCTCTGTGTTTTTTTACTCCCGCTAAAAAGTTAGAATGGGAGTCTTCACTTTTATTTTCTAAATTATTTTGATTTATTTAAAAAATACAATTATAGCAAAGTATTTTTTTTGGTCTACATCTTATATTGGTCTGTCTATCTATTGAAATGGACATCAAACGTGGAGATTGAATTTGGTATGGCGGAATCGTCTAGGTATGATAATTAAATTACGTCATGGCTAGGAGTTAAATGGCAACTACTGCATGAAAATGAGGTGTTTTGATTACCATAAAAAATATAAATCGATTTGGGTATGTTTATTTTTGTGCCTGAAGTTGTCTAATTTTTATTTCTAAAATTTCTTTTAAGGATAGCTCTTTCGTTACGAAAAAATCTTGTTTTTGTATATTTCGAGAAGCTTGACTTTTGTATATTTTTCTGTGGTCAAGTACCGCATTGTAAAAACTTTTGATAAAATAAAAGTTGCTGTCTATTTGTTTTTCGTAGTTGGCATCGTGTTGTATATTTCGACTAAGCACTTCGGCAATTTGCAAAGTTTTTGTGGTTTTCCCAGTTTTCTTACACAGAATAAGAAATTCTTTTATCTGAGCAAACTTTTCTTCGCTACAAGTTTTTACCATTTTTGGACTAAAGTAGTACTGATTCAGTTTTTCCAACTCATCGAAAATAGAAATATCCTTCCTGACATATAGTCCAATCAGACTTGTTTTTCTCCCTACTTTTTTCAGTATTTTTTTCGTTTTTCTCAGGAGCAATAGTGTTCTTATCTGAAAAGGTTTCTTGTATTTTGTAAGTTCCCCTAACACCTTTATCCTTGCTTATCAAATTTCCCCATAGTTTTTTGAATTTTTCTTCGTTCACTATTTCATCAATCTAAAAAATAAAAATTGGGTTTCAATTAGAGGTACAATGTGTATATTAAGGTCATATTTTCATTTTATATAATTAAAAATAATATCAAAAATATTTTTTGCGTCAACTTTTTTTGCACGTTGGCTTTTGAGTTTTGTACTAGTATAAACTAATCGTCTCGTTTATCCAAAACAATGTAATATTTAGGCGCTTATGGTGAGCAATAACTAGCAAAATTTAGGTAGATTTGAAGAATATTAGAACATAAATCAAAATGTTTTCGGCAACGATGGGCAAATTTATGAAGACTCTCTTTTCTCAATCGCAAATAACAATCAAAAAGCTTCGCGCTTTAACAACAAAAACAACGCTGTCTGTATGGCGTAAAGTACTTTTTATTGTTATGGTTTTTCTAGTAAACAATGTGGCTTTTGCTCAGGAGAGCAACGAAAAACTACACGAAATTTTTATCGCTCTGTGTAGTGACCACCAACAAAAATCGACCGCTGCAATGCATGAGTTGATTATGCTCAGCAAAAATTCACCAACATTGACACGAGTACTACAAAAAATCGCAATCCAAGATTCACGAGAATGGATACGGACTCTCGCCAAAAATGCATTGCAATCCTCCTCCCAATCAGTGCAAAAGCTTATCGATGATCTTTATCCTACAGAAAAGACGCGTGCTTCTGGCCTTCACAAGTCTAAATCTCTTGGAGGTTTAACCATTCTTGGAGCAAGCCACGACTTCCGGCAACGTCTACGCTACGGCAAAAAACACGCTTTGGTCATTGGTATTAATCAATATGAAAAATATAGCGATCTGCAAGGACCAAATTTCGATGCCGCCGCGGTTGCGTCGGTTCTCGTACGCCGTTATGGTTTTGACGATGTGGTACTCTTGACCGATACTTCGCCACAGAATATATATAGAACTACGGAAAAATGGAGCATTCGCGCTGTGAATAAACAAACGATTGCCGATTACTTGGCGATGTTGCGTTCAGGAAAAGAAAGAGGCAATTACAAAGTACGTCTATCGCAAGTGGATAAAGACGACGCGCTATTTGTTTTTTTTGCTGGCCATGGTATACCAGGGTACATTGTTGCGGCAGACAGTCACAACGAATCCACTGCGATTTCTCTTAGGTGGCTTGCCGAAGAACTTGCGAAGTGCAGAGCACAGCACACGTTTTTGGTTTTGGATTGTTGCTTTAGTGGCTCTATTTTTTCTCCGCCATTTCGTCCGCGTTTAGGCGCGTTCGATGTAAAAATGGATTTTCATCGTGGCGAAAACATTGACCGTGTTTTTCGACGACGCTGTTTTCAGATTGTTACTGCCGGAACAGGGGGCGAAGTTGTTGCCGATCAATTACGTCTTTCCAGTATCTACGCGCAAAAAAATCGCAATTTGCGCGGGCATTCACCGTTTACCGCAATTTTCCTGCAAGCGTTGGAAGGACTTGTCGGTCGCGAGGATGGTATTGTTCTTACCTCTGACCTCGGTTATTACATGGGAACGACGTTAGTCAACGATCGGCGCATAGACGCCTTGCAAACTCCTCGTTACCAAAGTTTAGGTGGAGACGGAGATTTTATGTTTTTTCCCGCGCATAAGGTACTCAATCCGCGGCTACTGCAAATGTTGTATCTCGATGAACAAAAATACGCAGAAATCAAACGTTCTACTTGCGCAGCGATACAAAAATTTATTCTCGAACAACCGCGAAACGACCATCTACCATTGACGCGTAGTGCTGTTATTCACATGTCAAAGCTTTTGGAAGAGTCACAGTTTTTGACATACCAGGGTGCTGTGCAATTTATCTACAATATGTTGCATGAGCAAAAAATGGACATCGCACAAATCCCTGAGTACAGCAGTGTGGTACTACCTTTGGCAAATCTGCTTGATAAAACGCTTAGTGCCACTAAGTCACCACAGCGAACGCAAATCATGCGCAAAATCTCTTATTGTTTGGCCGCTCTCGATTTATATACAAATGAAATCGCTGTAAACGCCCTAAGAGAATACATCCATTTCCAGGATGCGGAGTGGAAAAAATATCGTCAAACGCGACACATCCCGACAAGTGTTTTACTATACAAAGAGAAGCTCTCAAAGCTACGAATAACAGCAGAATCTTTGTCCGAGCAAATGCGTATTTATGCCAAAAAAAATGCCATTTATTTGTGGTTACACACAAAGGGGCGTCAACAAATCGAGGAGTATCAGCACAATCTTGTACAAAGTCGCTCTCTGGCACAAACTGTTTTGCAAAAGGCAAAAGAAGCATACCAACAAAAGAAATGGGAGCAATGTGGAGCTTACGCGGGTAAGGCCTTACAGGTAGTGAAAGAATATCCTCCACTACACAGCCTGCGTCAAAAAGCGCACACCTATGTTCGGTTAAGTATGTGGCACAGTGCTACGTTATGGAAAAAATATAGCCACAGCAAAAGTGTTTTCGGACAAAACGCTGCCAAAAACGCACACCGTGCGCAGATTTATGCTCTTAAGTATAGTCACAATAGTCAGACACTCGCCAGTGCCTCCTATGACGAAAGCATCAAACTGTGGCGAGCACAGGATGGTGTATTTTTACGCGACATTTTCCCGACGATGCAACACCAACCATTGCAAATAGAAGCCTCAAGTAAGGCCAATATTCTAGCCATTTTAACGGGGGGTGGTTTTATCGAGGTGTATGACCTTGTTCTAAAAAAACTCATTTCTACCATAAAAATCGGTAAAGTCGAGCGTCCTATAATGGCCATAAGCTCAGATGGAAAAACGATTGCCCTTAGCGATCAAAGCGAAAAAATTACTCTATATAGTGTTGCGCGAGCAAAAAAACAAAGAGAGCTTGTAGGTCATAAAGATGATGTGACCACTCTAGCGTTTAGTCCCGACAACCAATGGCTAGCAAGTGGCGCTTTAGATCATGATATTTGCCTGTGGAATTTGCAAAACAATCGCAACAAGATTCTATCTGCACACAAAAATGCCGTTATACAGTTGTCCTTTAGTTACCACGGAGAACTTCTCGCTTCGTGTTCACAACGCAACACTCTTGTTTGGGATCTAAAAAAGCACCAAGTAGATTTAATAATTCCCGTAACGCGCTATCAACGTTTTACCGCAGTAGCTTTTAGCCGCGATGACCGTTTGCTTGCTTGCGGAACAAGCAAAAACATCGAATTGTTTGATATTGCCGCAGCCAAGTTAACACTGCAAATCCCCACTAAAATGCATAGTTCTTTTTTGTGTTTTCACCCCAGTGGAAAAATTCTCCTCGCTCATCAACATTTCTTGGGAGCGGTTGTAGCGTGGGATAGCAAAAATGGCAAAAAACTATATACCATCACTAGTGATGCGCGTACAACTTCCATGAAAGCTCGTTTCAGTGCGGATGGCAAATCCGTAATTGTATCTGCCCGAGGAATCGAAAAAAATATCCAATTTTTTGACGCTCTTAACGGAGAAAAACAAAAGCCACCTTTAAAAGAGTGGTTTCGTCACGTAATTTTGCCGAAGAAAATGGCATTTGGGAAAAGGCTTTTGGCCACAAGTAGTAAAGAGGGAACCCTCATTATATGGAACGCAAAAACCGCAGAGGCCCAGCATATTATTTATGAAAAAAATATCGATAAACTCACTTTCAGTAGTGACGACTCTATTCTAGCTTGCACTGTTCATAAACAAATTTATCTATATAACACCGACACCGGAAAACTCTTACACAAATTGCCTGGACACCAAAACAAAATCAATTCGTTGTCTTTTTTTCCGACAAAGCCCGTACTGCTCTCCGCGGGAAATGATAACAAAATAAAATTTTGGAGTAGTGATAACGGCACACTTCTGCAAACGTTACCAACACAAAACCGCGGAGTGCTCACTTATTTTTGTAACGACCAACGCACCCTAGCACTACTTTCCGGATATGAGAATATCAATGTACAACTAAGCGATATTTATAGCAAACAATCACACAACTATACTCTAAATACCACAAAAAGAGTCTACGCGCGCTTATTAAGCCAAAACGGCGCTATCCTGGCCATTGATGGCGGTGATACCTATGAGATTTGGGATGTGCGCAACGAACGTAGGCTAAGAACTTCGATACAAAAAAATATGCGACAATTGGCTCTTGCACCCGATGGCACTACATTCGCATATACCAACGCACAGCATACACTGCAACTATGCAAAATTCGACCTTTACCCCAACGAGTATTCTTACCAGCAAAACGTTATCAACATATCGCCATGGGTTCTCAAGGTAAATTTTTGGCTTTTTCTAGCGCCGACGAACTAGGCATTTGGGATACCCACACCAACAAACTGCACAAGTCTTTCAAAGGATACAATGGAGAAATCAAGTCATTAGCGTTAAGCCATGATGGCAAAATTCTTGCTAGTGCGGGGGAATTCCAAGATCCACTGGTACGCCTGTGGGAAACAACCACTGGCAAGCTACGCCATGCTTTAGACCCTGGTGATAAACGTCTCGACCAAGTCGCTTTTTCCCATGATGGAAAAAGTGTCGGAGTAAGTGTCTCCGGAAATCAAGTCTCGATTGTTCTGTGGGACAGCGACAGCGGAAAAAAACGCCGCGTTATCTCTAGCCCAAACCACCAAAGTGCAGCACAGACTTTCTTGGCATTTTCTCCGCAACAAAGTATTTTGGCCTGGGCGCGTGATAACGAAATAGATTTGTGGGACGCCACATCGGGCAGGAGAATTTGTCAAGTCGCCACCAATAATCCGGTAAATAAAATTTTCTTTGACGCAACAGGGAAAAACTTAGTCTTGGTAAATCCAAGTGCCATTGCCCTGTGGAACCTACAACAACGTAAAGTCATCGCACAGTTTAGGGATCAATATATCAATGACGGTGCTTTGACAACCACATCGAAATATTTAGCCGCCGCCACCAGCAACGGCGTACAAATTTGGGACGTAATTACCGGAGAAAAAATACAGCGTTTTCATGAAACGAGAATTTTTGATAAAGTCGCTTTTCACCCCAAAAAGCCATGGCTAACATGTATCGATCACAACGCCGCGTCGCGAATAAAACCGCAAAAGGAGAGTTTGTTTTTTTATGATTTAGCTGAACTTATGCAAGTCCACACCAGCAAAAACATGCCCCGTTATGCAGCACATAGAAAAAGCAATCTTTTACTTGTAAAAAACGCGCAAAAAGAATCGTTGTGGAACTTGCACAACGGAGTAAAAATGTCCAAAAACATTTCATTCACAAATGCGAAAAAAATACACTTGCCACAAAAATACTTTGCCTACCCGCGTCAGGATATTCCAGCCGACATTATCGAATTTGCACTACAAGAAACCCCCAAACGTTTTACAGAACAACTGTTTGGCTATCGTGTGGCGGAGGACTTGTCGGTGGAATAAATATTTTTGTGGCAGCCTATATAAATATCTTTTTGCATTGTTAAAAATTGAAATATCTTATGCGATTGTAAATCACTAAATTGAATTGTAGACATTTGCTATTCCACCAAAAGAGTTTTGTCCAAGAGGTGTATATAATTAAGACCTAATCCCCGAAGGGGAATTAACATGTTTAGCCGTAGGTGTTAACCTACGGTCAAAATGTATAGTTATAACATAACCCCGAAGGGGTGAAACTAAAAGGTCTGTTTATGTCTACTTATACACAAATTTATTACCACATTGTTTTTTCTACAAAGAACCGACAACCGAGCCTGACAAAAGAATGTCGCCCTAAGCTTTTTAAGTACATCTGGGGAATTGTCAATAACAAAAAATGTCGCCTTATTCGTATTAACGGTGTGGAAGATCATCTCCATATTTTAACAAAATTCCCAGAAGTCCCCATCCTCTAAAGGTTGGGGATGAATGGGCTTCTCAAATATTAGATGAAGAGAAATAATTATTTTTCTTCATCTAAAAATCAAGCGATAAAAACTACTTATGCCGTAAGAAAATCGTATTTTTTTATTGACACGAAAAATAAATCCGTATACAATTCGTATAAAAATAGTAGACATGTCCTATCTACAACCATAAATCTTTATGGTTGTATATTTGTATTCTTATTAATACAAATAACTCTTTATAACGAAGAGAATAAAAATTCCATGGAAATATGGAATCATGTATCTACGGCCTGCTGCTTGCGGCAGAAAGTAGTAGAAAGCTCTGTTCCGAGCCTGTAGGAGAGTCAGGTAACCACCCCTGATTCATTTGTACTACAGTTGTCAGGAGTACTAATGGAATAATACGCATCCTTCGTGGATGAGGTTGTCCTTGTGGATGACCGTCTGTGATTACCTGATGTATACTCCTTGAAATCTCTTGCTTTTGGAAGCCCCGGCTTCTTCAAGCCGGGGAGGGTTCACTTAGTTTACATCCAAGCATTGATCTTGCTGATTTGCTTCGAAATGTTAAAGCTTTTTCAAGCAAATGGATTAAACAAAACAAGATATTTCCTTGTTTTACCAACTGGCAAGATGGCTATGCAGCTTTCACTCTTTCTTTTGATAACGTTAATTCCGTTATTGAATACATTATCAATCAAGAACAACATCATTACAGAAAAAGCTTTTTGGATGAATACAAAACGCTTTTAATACAAGCTGGTATACAATTTGATCCCAAATATTTACTCTAGTTTGACCCCTTCAGGGTCAGAATTTTGTTTCTATTGTTACCGTGGGCTTTGCCCCACGGCTATACACATTTTTCCCCTTCGGGGCAACTTCGAAATGTCAACAGAGCCTATGCATCGCTAGATTCAGAGAGATAAACTTTTGCCTTTCCATTTCCGCACAGTTGAAACTATAGGTTGCTGAATCGTGTAGCTTTTTTGTTGTACATGTGCTGTCATACATACGAGTAAAAGTACAAGTAAAAAAATTATCCATGATTTCTTTATTTATGAATAAAAATACCGCTCAAAAAAGTAAGAGAATCCCTTATGTCAAGAATTTTTTTCTCACTACCGTTCCCAACTAATAAGGTGAACAAATATTAACAGTTCTTATGTTGTGTAATTGTAACTGAAGATTCTGTCCGTTTTAAGAAAAGGGAAGAAAAGGGAAGAAAAGGGAAGAAAAGAGAAAAAGATGGGAAGATAAAAGGATAGGGCGTGGGATTATTTTTTACTCGATAACGATTGTTCTAGTAGCTAAAATAGTGCAGTTAATATGAAAATTTAAATCGAGGTAAAAATGATGTTCAAAATACTAATTGCCACACTTTTTTTTATGAGCATGATATATGCACAGGATATTTGTACCACTCTCGATTCGGGAGAGGGGTTTACCGAGCAGTCTTTTGAGGAAAAAGAAGGACTTTCACTCGTTGGTGCCAAAAATAAACTGTGGCCAAGCAATGAACGTGTGTTGCATGTTCGTTTTGTTGGAATTGACAATGATGATATTGAGCAACAAATTGAGGAAATCGTAGAGGACAATTGGGAAAAATGTTGTGGGATTGACTTTCGTTTTAACAATGATCCTAAAGCGCAGATAACAGTAAATATAACACATGGAGTCGGTAACAACTCTCAGATAGGAACAGACTCCAAAACAGAAAATCCCAGTATGAATTTTTCTTTTTACAAGAAAAATAAAAAAGGAAAATTGTATTTGCCAAAGAATTTTTTTACAGTTGTCGATGGTAAAAAAAAGATCCCTAAAGATAGTTATGAATATGGAACTATTCTTCATGAGTTTGGTCACGCGATGGGCTTTAAGCACGAACAACAAAGCCCGCGTTTTAACATAGAGTGGCATGAAGAAAATGTTTTGGCTTACTATAAAAAACACAGTCCAGATTGGACAGAGGAAGATGTTCGTCACAATGTACTGAATAAACTAGAGAATTTTCGTATTGCGCGAAACGTGGTTACTTACGAAACGGAATGGCTTTTTGGCTTTATTCCAAGAGTAACGAAAAAAATAGACCGCCGTAGTATTTTTATTATCAATTACGAAGCCACGGCTTTTGATCAGCACTCTATCATGTGTTATCCTTTAAAATTAGAACTTACAAAAAACAGAACAGAATGGCGTTTAGGAACTTTAGACATAGACTACAAAAAAGATCTAGATGCAAATAACTACACCGACAGTTTACGCAAAGCACTGGCGAAACAAAAAGACATTGATGTTGATTTCACTGCAAAAATTACTGCATATAAAAGCGGATATTGGATACTACAAACAACTTTGCCCGTAAATAGTAAATTACCAACGTCAGCAAAAGTACCTAAGAAAAGTTATCGCATTATTGAGGTCGATGGTATTTTGGAAGTATACCCAGCACTTGGCGGCGGACGTAGTCTTTCGGTGATGGACCGCTATTTTTCTAATAAGCTTTATCCCTTCCCCACAAAAACACGAACGCATAATTTTGTGGTACGCGAAGTAAAGCGTGCCTTTGATGAAATATTATTGCGCAAACCAACAGCTGACGAACTGTCTTATTATGTCAACTACATGAAGCAAAATGATTTGCTAAAACTACGCGATGAAGTGGCAAATTTAGCGGAAGAAAAAATCAAAAATCTATACTTTTCTCTTGCTGGTCGCGAACCAAGCCAAGAAGAGGTAAAAAATGACAAAAAGCTACTGGCAATGGAAAATTTTGCGACCTTAGAGGCCAGCACTTCTTTAGAAGTAAACTTGCGTTCGCGAGAACAATTTGGTAATGTCGCGCAGTTGCAAGTTATTGGGCTCTACAGTGTCCATGCCGGAGGAAGTTTTTACGTTAACAACAATGAAACAGTGGAGTTCCGTGCTGGTGAAGAAATACTTCTTCAAGAAGGTTTTACTGCCAAGGCGGGAAGTGATTTTACTGCACGGCTGTATAGTAAATAAACACCGTTTACATTCCCTATCCTAAGTCACTTATTGGTAAGAAAAGCACGAGATAGGGAGATGATCATCAACTACTAGCCATAATAGGAACCATTATTGCCGATTCTCTCTGACAAATCGTTTATCTGTGTATGGAAGAATCGGCAAACCTCTAATTCTTTATAAAATGCTACTGCGAATAGTCTTACGATCTTGCCCTCCACCTTCAAGTAAAGTACCTTTTATACAGATGATATTGGCGATTTATAAATATTGCACACGACTATTTACCATTTCTTTTACAACAGTGCTTTATCTGTAAATATATTACGATACAACTGAGAAAGTAGTAGTACGTTGGTAGGGATCGTAGAATAACATACAAATCTTAGTCATAATCTTTTCTTTGTAGAATTAAGATTATGACTAAGATAAAAAACGAATTGAGCTTATTTATTACGCATTATCTTTAGAACCAAATCCAATTGCTTTTGCAAAGCATTTATTTTTTGTTCATTTTGTTGCATGTTCACTAATTGCTTTTGCAAAGCATTTATTTTTTGTTCATTTTGTTTCATTTTCGCTACTTTGTTTTCTAACGTATTTTTTTGTTGTTGCAACGTTGTGATTTTCTTTTCTTGTTGGATGGTATAAAGAGTAAGTTCTTCTATTTTTTGCAATAACTTTGCCTGCATTTCTCCCAACTGAATCCCCTGTTCTTTTACTTCTCTCTCTGATGGAATGTTGGGCAGATGTTTGTTGCGTTTAATGGACTGCTCAAGTTGGTCAATGGGAATAAGTTTGTAGTCATCGGCAAACACAAAATCTGCCCAGTTATCCATTTTTACGATACGCACTTCTTCTGCGGTGATTTTTCCTTTTACCGCTAGTTTTGTTGCAGCATCAGCTAGCTTGGTTACTCCAATTCCAATACGTCCATTCACTGCAAGGGTGAAGTCTTTAACGGGAGCAGTGTTCATTCCAATCCAGCCATCTTTATCTATGTGCAAGCTTTTGGCATCAAATTTTTCGGTTACGTTTACACTTTTTGTTGATATATGATTGGCATTTAAGGTTTTATTTGTAGTCAAATTGCCTTTGACAGAAACATTTTGTGCACTATCCCAGTGTAAGGCAATTTTTTGTATCTTGTTGGTATTACTACCAAGAGCACCACCATAATATCCATAAACCACAGGTCCATTTACATTTTCTCCAGCAAAAAGTTTGGCAGGGTAATTTTTATTACCATCGCTGTATGCTGCGTGATATAAGCCTATACCATGATTGAAATCAGTAATGCTACTATGAAAATAAACATCTCTACCTTTTGTTGAGATTCCCTTGTTGTTTATGTATAAGTTTGTAGAGGAAATTTCTAAAGAGTAATTACCATTGTCGAAAACTCTTTTTATTGTTCCACCACCATTTAGAGAGATGATATTCGCGTTTACTTTACCAATACTCAAATCTTCGGCACCAGAGATTTTCTTCGCTGAAAGTTGACCAGTGACTTTCACATCACCATTACTATCCCAGCGTAAGGCAATTTTTTGTCCGCCTTCGGTACTACCAAGTGCACCTCCATAGTAACCATAAACCACAGGTCCGTTCACATTTACATTGGCAAACTTTTTAGTGTCGTGGTACATACCTATACCATGAGCGAAGTCAGCACTGTCGCTATGAAAATAAACATCTCTACCTTTTGTTGAGATTCCCTTATTGTTCATTTCGATATTTTTTGCTGATAGCTCCAATACGTCTTTTGGTAGATATGTATCACTAACAGTTAAATTTCCTCCAATCTCAGAATCACCATTGCTTTTTGTGGTTCCATCAACATCTAGCGAATCAGTTTGCGTCTTTATACTATAGATTCGCTGAATAGCTATTCTTGCCTTATTATCTCTATTTTTATTGAGGATTTGATTGAGATGATCTCGCAAAATTATTTCTCGTGGTTGATCATTTATAGCATAAACAGATATTACTTTATCAAATATTTTTACTTCTACGATAAAATCAACATGAGTCCATCCATTTGTTTTTTGTATCTTAAACCTACCATCATCTTGTTCTAATATTTTACCTTGGACACAGTTTACATGTGCAAATTTTCCTCGGGAATCAATAATTAACTTGTAGTCACCTCCGAATACGCTTACGCGAAGAAATCTATATTTGCTAAGAGGTAAAAATTGTGAATTTAATATATCGATTTGTTTCTGTAGCAGATTACTTTTACTCTGTTGATTTTCTAATTGTTCCTCAAGTAGCAAGTTTTCTGCAGTTTGCGTCTTTATACTATAGATTCGATGAGTACCACCTATTCTTACCTTGTTATCTCTATTTTTATTGAGGATTTGATTGAGATGATCTCGCAAAATTATTTCTCGTGGTTGATCATTCCTAGCATAAACAGATATTACTTTATCAAATATTTTTACTTCTACGATAAAATCAACATGACTCCATCCACTTGTTTTTTCTATCTTAAAGCTACGATCATCTTGTTCTAATATTTTACCTTGGACACAGTTTACATGTGCAAATTTTCCTCGGGTATCAATAGTTAACTTGTAGTCACCTCCGAATACGCTTACGCGAAGAAATCTATATTTGCTAAGAGGTAAAAATTGCGAATTTAATATATCGCTTTGTTTCTGTACCTTTTCTAGTTGTCCCTCAAGTTTTGAGATTCTTGTATTCATTTCATTAATTGCTACATTTTTATCGTCTTCTGCAAATCCGAAGGATACAAATACTAATATCAAAAAAAATGTTTTAAGATAATTCATTTTAATCTCCAATAATGTTCTGAGCTTCTCGACACTTGATAATTTTTTAGCCCTTTGTTTGGGCATCTATAAGCTAAACGGTGAATAAATAAAAAGCATGCCTGAAAAAAAGTATCCTAAAATAGTCAACAATTACACAAATAAGGATACAAAAATGCTACGCAATGAATAGATAATACAAATAAAGGCGCATAATCTGCAAGAAGAACTAAAAAATGAGGAGAAACATTATCCGAGCTAGTCTGTCTACAGTGAATTTCTCTACACATTTTACCGGAGAAAAAATGCAGCATTTTCATAGAAAGAGAACTTTTAACAAAGCCGCTTTTCATTAAGAACATTTTTTATTCTTTTAGATCTATGACAAGTCTAGTTTTGTCCTTTTTTCATTTCCTCTTCGACCTGCTTCGGAGGTTTTCCTTTTAGAAGTAGCTTCACTCTTTTGAACGCTTCTCCTTGAGCTTTATCCGCGTATTTATTTGCCTTTTGGATATTTCCTTTCCAGGCATATATTGCTGCTAATGTATCAAGTTGATGTGTTTCATATGCTTCTTCCAGAATAATTATATCTTGTTTTGTAATTCCGCCTGACTGTTCTTTCACATAATTTTCCCATAACCTGTCATTGAGAAATTTAAAGTTATTTTTTATTACCAACTCCACTTGATTTTGCGAAATTCCTTTTAGCAATAAGTTGATTCTTATTTTTGCATTCTTGCTACAATTTTTAGCGTATTTTAATGCTTCTTTTTCATTGCCTTTCCAAGCATGGGTGATCGCTACTGTTTCAAGGTGTGTTTTATCTTTCGATTGTGATAGAAGTTCTATGTCTCTTTGGGTGAAGGCGTTTTTGTATCCATGGAGATATGATTCCCAAAGATAAGAATTCAGTATTACATGATTTGATTTTCTAATAGCATGTAATGCCTTTTTTCCTATTTTACTGAGCGCTTTAGTTACACCTTTTCGTATCTCAGGATGTTGATTTTCGAGAAGTGGAATTAGATGAGGGATCGCTTTTTCTCCGATTTGTCCAAGTGCTTCTGCTGTACTTTCGCGTACTTCAGAATATTTATCTTTGAGGAGTGGAATTAGATGAGGGATCGCCTTTTCTGCTTTTTCTCCTATTTGTCCGAGTGCTTGCGCTGCTCTACTTCGGGGGCGATCTATTTTTCCAAGTGCTCTACTTAGTATGCTAGAGGAGGTATCTTTAAGAAGTGGAATTAGATGAGGAATCGCCTTTTCTGCTTTTTCTCCTATTTTCCCAAGTGCTTGCGCTGCTCTACTTCGCGTGTTAGAAGAGGGATCTTTAAGAAGTGGAATTAGATGAGGAATCGCTCTTTCTCCTATTTTACCAAGTGTTTCAGGTGCATTTTCATACACATTATCTTTAAGGAGTGGGATTATATAGGGAATCGCTTTTTCGGCCTTTCCCCCTATTTTTCCAAGGGCTTCCATTGCGTTTATTGTCACCATAGGAACTTCATCTTTCAGGAGTGGGATTAGATCGGGAATCGCTTTTTCTACTTTTTTCCCTATACCTCCAAGAGCTTCTGTTGCATATATTCTGACATATTTATTTTGATCTTTGAGAAGTGGAATTAGATCGGGGATCGCTTTTTCTGCCTTTTCTCCTATTTTTCCAAGAGCTTCTGCTGCTCTAATTCGTGTGCTAGAGGATGGATCTTTGAGAAGTGGAATTAAATAAGGAATCGATTTTTCCTCTAGTTGTACCAATGCTTCGAGGATTTCTTTATAAGCATAAAGTTCACCATCACCGCGAGCTTCTTTTTTCAATCTCGATATTAATACAGGAATAGCCTTTTGTGACTTTTTCCCTATTCTTCCAAGAGCTTTCGCTGAAACTCTTCGTATTTCAGGATTTAAACCGTCTTCAAGAAACTCCATTAAATAAGGAATCGCCAAATGAGATTTTTCTCCTATTTTTCCTAGCGCGGAAATAGCTTGTACTTCCACACCTGTAACTCCGCTCCCTAGAAGTAAAATAAGCTGTGGTATCGCAAGATATGACTTTTGTCCAAAATCTCCTAGTATATTTGCCGTTTCTACTTTTACCTGCAAACTCTGATCCTCTAGAAGAGGAATGATATGGGGTACTACATTTTTTACTTTTTCCTTTGCCATCGATAATGCAACAGCAGCGGTTATTTTTACTTGCGCATCTCGATCATGTAAAAAAGGGATAAGAGAAAAAATAGACTTTTGTGTTGTCAAACCTATGTTGACAAGTGCCTCAATGGCAACATCTCTCACCTTTGAATTCTCGTCTTCTAGCAATGGAATGAGGCAAAAAACGATTCTTTCTGACTTTTCTCCTATTTTCCCTAAAGCTTCCGTAGCCAAACGTCTCAAGTCAGAGCTTTCATCTTGTAGTAGCACGGCAAGAAAAGGAATCGCCTCTTCTGCTTTCGCCCCAATTTTTCCTAGAGCTTCGACTGCGGCGCTTTTTACTTCTAAATCTGAATCTTTTAGAAGAGAAATAAGGGACGGTATTGTCTCATGAACTTTTTCACCTATTTCTCCCAGTGCCGCTGCTGCTGTCATTCTCATTATTGGAGCACTGTCTTGTAAAAAAGGCATAAGCAATGGTATCACCTGGTCAGCTTTTTTACTTATTTTTCCTAGAGCTTCAACTGCAGAAAGTCTTCCATTGTAATTTTTCTCTTGTAAGATAGATATAAGAGAAGGTACAGCTTTTTCCCCTATATCATTTATTACGGAAATAGCATACCTTCGCACTTCAGGATTTGAATTTTGCAAAAGAAAAGTCAAAGAGGGGACAAATTTTTGCGTTTTTTGCCTAATTTTGTCTAATGATTGTTTTGCTTTCCATCTTAGAAGGTGACTATTTGACAGCTTCATGAGAGAAGGAATACAAGAAAGGGCCCTTTCACCTATATTACCTAATGCTTCTACAACATCACCTTGTACTTTGTAATCCCTATCTTGCAAGAGATTCTTGAGAAATGGAACAGCAGAATGAGCTCTTTCGCCTATGTTTCCCAGCGCTATAATGGCTGCCTTTTTTACTTTTGAATTTGAATCTTCTAGAAGAGAAATAAGAGCCGGTATTGCAGAGTGAGCTTTTTCACCTATTTTTCCCAACGTAGTTGCTGCTGTCTGTCTCATTCTTGGATCATCATCTTGTAAAAAAGGGATGATTAATGGTACTGTTTTTTGAGCTATTTCGCCCATTTCTCCCAATGCCTGTACAACACAACCTCTTACATAAATATCTTTGCTTTGTAAAAGAGGAATAAGGTGTACAATAGCGGCTTTTCCTCTTATTTTTCCTAATATTTGTATTGCGGGGTATTTCATTTGTGGATCTTGCAATAACGGAATTAGGGCAGGTACTGCCATATGCGACTCTTTTCCCATCTTCTCCCGTAGTTCTGTCGCCCTTGTTTCTATTAAGAACTTTGCCGCAGACAACCTTATCTCATTATCCTGGTTATGTAGGAGAGAGAGTAAGATAAGAATATCCTCTGTGTCTATTCTCTTTCTACTTCTACCTACAAAAGTATATTTCATCACTTTTGTAGATGGATCTTGTGATACAGGGATTAAAAAAGGATTTTTGCATATGTTTTTCAACGCTGCTTCAACTGTTCTGTTTCGGCGTCCATTTTTTTTAAGAAGAGGAATGAGATATGGTATTGCTTTCTCTGCTTTTCCTCCGATCTTTCCTAACGCTTTAACTACGGCTAATTGGTTTGCTCTATAATTAAGTAAAGGAATAAGATACGGTATTGCTGGAGAGGCCTTTTCTCCAATTTCTCCGAGAACATACGCTGCATCTGCCGTAAAAGCCCCCGGCTGCAATAGAGGAATAAGTGCTGGTATTGCCACATGTGCTTTTTCTCCCATTCGCCACAGTGCACGAATAGCTTCTTTTTTTACGTAGCGATCAGAATCTTGCAATAGAGGAATAAGTGCCGGAATTGCCGCATGTGCTCTTTTTCCTATATTTGCTAATGTACGAGAAACCGACTCTCTAATTTTTGGGTCAGCATCTTGCAATAGAGGAATCAATGTTGGTACTGCCTCATGTGCTTTTTCGCCCATTTCTGACATTACACTAATAGCTCTTTTTTTTACATGGGGATCGGAATCTTGCAATAGAGGAATCAGTGCTGGAATAGCTATTTCTCCGGTTTCTTGTAGTACTGTGGCCACAGAATCACCATCTAAATTTTTTAACGCCTCTATGAGAAATGGAATGGCTTTTTTTCCTATTTTTACTAATGCAAGAGAAGCATTTCCTCTAACTTTTGAGTTAGAATCTTGCAATAGAGAAATCAGTGCTGGTATTGCAAGATGTGCGTTTTTCCCTATTTTTGCTAATATAAGAGAAACATTCACTCTAATTTTTGGGTCAGAATCTTGTAACAGTGGAATCAACGCTGGTACTGCTGGATGAGCTCTTTCTCCCATTTCTTGTAGCGCTGTAAATGCAGAAAGACGGGCATTTTGTTGTGCATTCTTTAATAAAACAATGAGAAACGGTATGGCTTTCTCCCCCATCTTTGCTAGTGCAAGAGAAGTATGCTCTCTAACTTTGGAGTCAGAATCTTGCAATAGAGGAATCAGTGCTGGTATTGCGGAATGTGCTTTTTCGCCCATTTCTTTGAGTATTTTAACCGAAGAAAGTCGGACAATTTCATCCGAACTCTTTAACAATTCGACAACAACCTCCAACATGGAACACTTTTTTTCTGGTGAGATTATAGAGTCTATGGCGGTCAATTTTTCAAAAACGTTTTTCTTTTTTAAAGAAATAAAAAATTTCGCAATAAAAGGCTCTATCGTTTTACGCTTTCCGATAAAAAACGCTGCCTGCGATCTTATTTGTTTATTTTTACTACCATTTAGCATAAGAGAGTATAGTTTATCAAAAGCTACTTCTGCAAAAAGCGGTATCAAGAATTGTTTATCTTGGTAAGTTAGATGATTTATAAGTGGAAACAATGACTCTTTTTGCCAATTGATTAACGGCAACCACAGATATTTTTTTTGAGATAAAAGTTTTTTTGCTTTTGCTAATTTGAGCCTATCAACAATAACAAAAAAAGCCCTTTTGCCAATTTTTTCAAGATCTTTTGCAGCATCAATTTTAATATCTTCACCACCCTCTTTGAGCAATTGAAAAAGTATTGGCAGATCTCTATCTTGCCCTGCTAGAAATGCCAATACAGTTGTTCGTATTGTTTTATCTCGCGTCGCAAAGTATTCAATAAAGTCTCGATTTGTAAGTTCTTTTTTTAAAAGATCAAAAGATTGTAATCTAGTAGAAACATTTTCAGTGAGTGACAAAAATTTATTTTTGCTACTTTCATATAACTCTATTTTTTCTTTACCGGTGCTATGTAGCCAACGATATATTTGAATCCTTTGATGATAGTAGTGCCCTTGTACTTGTGGAGTTTTACTATTAATATCCACATCTACAGGAAGTTCTTTCATTCTTTCTTTTACAAGATACGGAATTTCTTTATCTTTTGTATGATCTCGCCATTGAGATTCTTGTTGCTTGTAGTATCTCTTCAAAATGTCGATAGGACCTTCGTCTTTTATGTGTGAATGTAAAGAGCCCAAACACTCTATCATCATATATTGATCATCGTTACTTAAGGAAAAAACTACTTTTCTTTTTTTTGGTGTCAGGGTTTTTGCCAATATTGGTACTACAATAGAAAATACTTCTATCTTACTAGCATACTTCTGGGCTTCGTTTTTGATAAACTTCACAGCAGCCATTCGCGGAATTTTTTGTTCATCGGTTATCAGTTTGACAACATGAGGTAACGCACTTTTTATAAGCGAAATCCGATCTTTTTCAGATTTCTCGGCGATAAAATTTTCCAACGCTTCACAGCCCGAACGACGAAAGGCAGCAAATTCAACGCCATTTAGATACAAAGGCGCAACCATTTTAGGGTTAAGTACTTTGTCTACAGGAAAAAACATAAAATCACCATTACCACCAAGTGTACCATAGCGAGGTGCTTGTGATGCATTGATCCTATCGTCATTCACCAGCGTATCCATCATGTAAAATCCCAATTGCGATGCCAGAATGATGCCGTCATCTCTTCCAGTTAACCCTTGTATGGCTTGTAAAAACACAGCCGTAAATGGTGAATGACCACGACTATCTTTAAATTGTTTTGCGTAAATAGTTGAAATCTCATCTAGTTTATCAGCCACCGCTTCATCCCCAGCTCCGGCGGTAATTACCTGGAAAACGCGGCGATTGAACACTCTAGTTAGATTGCTCCCCCCCGGCGAAACAAAGGCTTTATCTGTTAGATTGGAAAAATCAGGGCGATATTCTTTTTCGAGTAGTGAACCACTAAAACAACAATCCAAAACCATTAATGTGTGTCTGGCACCACAAGATTCTAGAGATTTAGCAATTGCTTTTAATGAAACCATACTTTTTTCAATAGGTCGTCCAGAATGTTTTTTTTCGCTATCCCCTACGACCAAATAACCAGGAACACCATGACCGGCATAGAAGAAAAACAACGCATCATCTGGCTTGACCTTTTTCTTTAAACTTTGAACTGCATCTTCAACTATATTTTTGGTTACTTTTGTTGCGCGCCCATTGAAATTTGCTTGCCTTGGAGAAGGTTTATCGAGAAGTAGATTAACATGATCAAATTGATAACGGTCGCGCAACACTCTTGCTATTTCCGAAGCGTCGAAATTGGGGCCTTTGAGATTTGTGAAGTTGTCATACTTGTTTATACCAATGACAACAGCGTATTGTTTGTTATAGCGTAGTCTTTGATGAAAGTCGCTGCTAGTTCCAAGGATATTCAACCCACCAAGATTCTTAGAGATGCGCGATGCGGCAGAGCGCGTTGTTATTGTTTTTGGTGTTTTTTTCGACTTCACTTGTTGTGGTGATGACTGTGTAATAATATCCACAACGCATTGAATAATCGACCTGTTATTGATATTTACTTTTTTTAGAATTTTTAGTAACTCTGGACGAATTACTTTTGCCTTATCCCCTAATTTTCTTAGTTCTACTAATGCAGATAAACTATGGTCAATATTCGAAGATTGTAGTTGCGCGACCAATAGTTCTAATTGCTTGTTCAGTTTTTCGTCTTCAGATTGTGCAAAAGCCAAACAAAATAGAATAAAAAATATTACAACATATTGTAAATATTTCCAACCCATGACAAACCCCATCAAAAAACATTGCTTCAAAATTATAAAATACCATAGCAAATTTAGCATACGTTTTCAAACTTGGTCTATAGTTAGATTTCGCAACAAAAAAAACCTTAGTCAACTTATTTTTTCATTTCTTGCTCTACCTGTTTCGGCGTTTTCCCTTCTAACAATAATTTTACTCTTTTGAGAGTTTCTTTTTCTGCTATATCGGCATATTTGTATGCCAACATAGCATTTCCTTGCCATGCATAAATCGCTGCCACAGTGTCGAGAATATACTTCTCCGTTGATTTTGATAGAAGTTCAACATCTTTTTGAATGAACAAACTTTGGTCTTCTTTGAGATACGATTTCCACAGAGGCAAAAGCCAGGAGGACAAGACAAAAGACGAACTGATTGAAAAGTTATACAGATAATTTGGAAAAGTCCACTCAGAATATGGGTGACTAAAAAAAGCTTGGTGAATTTTAGCAGTGCGGAAAACTTGATCTGATAGATCCGAGTGACGAAGAGTGTTCTGTACGTCAGCAATGTAAGATACTAGGTGTAAAGAGAAATACATTGTATTACAGAAAAAAGCCAGAGAGTAAAGATGACATTTCACTCAGAGATGTTATTCGGCTACTTTATATAAAGTATCGGTTTATGGGTATCAAAAGATGACAAAATCTCTCAGAAAAATGGGCTTTGGAGCAAATCGTAAAAAAGTACTTCGCTTGAGAAACGAGCTGAAAATCAGGGCGATATAGTCGAAACCAAATTTGTCGAAGGCTAACAACGAACACAAGAAGTACCTCTAAACAACACTAATTACTTAAATAGTTGTAAAACACAGAAATTCATTTGGTTATTTTCGTTAAAAAATTATAATAACATAAATATTTTGCCATCTCAATCAAATGAGAAATTTGATTATCGAAAATGAACTGTGCAGTGCACTAATAAATCATAGTCTGTTTATAAAACCAAAGGTGGTAAATTTTTTTAGTAAAAGACCTCAAGTTCTATAGAAGAAAGGTAATTGTTTGTGGATGACGTAAAATTTAAAACACTATGGGAAAAGCTATTGAATAATAGTGAAGACATAAGATACACATACAAACCCAGTGAAACATTTTCTGACAAAAACACTATTGTTCCACAAGATGCAACGGATACTTTTTCTAGTAAAGACACGATCTCTCCAGAAAATTCAAAAGAAACATTCTCTGATAATAAGACAATCACTTCGTCCGAAAATCCTGAAAAAGAAAAAGCATATACAAAAACTAAAATAGAAGTTCCACTAGACACAAAACAAGATTACACCGATTTAAAAGAAATCAATCGTGGTGGAATGGGAATTATCTATCAAGCGAGACAAAAAAAATTAAAACGAGACATTGCGATTAAAAAAATGCTGTCTGATAAAGGAAAAGAAAAATTTTTAGCCGAATCTTTAGTCAATGCCTACTTGGAACACCCGAATATTGTTCCTGTACATGAAATAGACACAAATGACGAGGGGGAAATTCTTCTCGCAATGAAGTTCGTTCAAGGGATATCATGGAAAGACTTATTGTACCCAAAAACAAAAGAACAACAAGATAGATCAGCCGAATATAATCTAGAAGGGCACTTAGGAATACTTCTCAACGTTTGCAACGCTATCGCTTACTCGCATCATAAAAATATAATTCACTGTGACTTAAAGCCCGAAAACGTAATGATAGGTGAATTTGGCGAAGTATTAGTAATGGACTGGGGAATTGCTGTTGATCTGGGATCTAGAGAAGATGAAGTAAAAGAAACAAGAACGTTCAAAAATACGGAGATCAATCATCCAATGGGAACTCCTTGCTATATATCACCAGAATTAGCCGAAGGAAGAGGAAAAGACATTTCGTATGCCACAGATGTCTATCTTTTGGGAGGCATTCTATACGAGATTATTTACAAAAGACCTCCTCATCAAGGCAATACAATATGGAAAGTATTGCTTTCAGCAAGAGAAGGGAATATGCCTCCTTTTGATGAAAGTGTACCTTACGAGTTAAGAAGTGTTTGCAAGAGAGCTTTACAAGGTAATATGGGACAGCGTTACCAAAAAGTTCAAGAATTTCAAAAAGCGATTCAGGATTATTTAGCACACCGCCAAAGTATTATTATTTCAGATAAGGCTAAAAAGATATTGACTGAAGGGGAAAACCTTTTTGAAATTCAGGAGAAACTAAAAGAAATAAATTTTAGTGTACTCTACAATAAGCTTTTGCAAGCTATTGCAGGTTTTGATCAATCTCTAGAGTTGTGGCAGGAAAATGTTGAGGCACAACAGGGGCGAGACCAAGCACGAATAGAATTTGCTAAGGTTGCTTTTCTCAATAATGACTTTGGTTTAGCCAAAGCGCAGTTGGAAGAAACTACTAGTTCTATTGAAGTAACCGAACTATTTAATCGTATTGAGTTTGCTAGACTACAACATGAGAATATTTCAAAAAAGTGGAAATTTTACTTTCGTCTTGCCATAATCATTATTATTGCATTTTTGTTAGTGATTATACGGTTATCTACTACTTATAAATTCTAATGCAAGGTATAAAAGCTAAATGGTAAAATGTAATCAAATTTAAAGTAAATTTTGTAAGGTTTACAAATGGAATATTACGAACTCGAACAACAGCGTACGGAGACCAAGTGGGTATGGATTACTCTTATGATCAACTATATTGCACTAGTTTATGCTGATAATTTAACACGCACAGAGTACGGTTCATTAGCAATAGTAGTCCGAATTATGGTCTTGACTATTAGTCTTTCACTTTTCATGAGTCTTGGGAGGTTAGGTCGCCGAACGGGAGTAGGAAGTTGCTTGGGGATTTTTCTTGCCATAATTCCTTTTATAAATACACTTTATGCTTTTTTTCTACTAAAGAAGTCTCGAAAACTTCTTGATAGAGTTGGAATTAAAAGAAGTGATTATAGTTTAACAGCAAAAAAAGTATTTTATGATTTCGATACATTCAAAAAACTCAACAAATATTATTTTACTGATGAAATGCTAATTTCTTATGACGAACAAAAATTTCAAAAAATAGGGGAGTTACTTGAAGAATGGAATCTTTATGATTTTTTTTATAGAAAAGGGCTTCTCTCGCGATTAATGCATTATTCTTTACGCAATGAGAAATATAAAAAGCTGGAGGAAACTATCGAAAACATCAGCGAGGAAATCAAAAATGCCATTGACTATGATCGTCCCATAGAAAAAAAAATATACTTTATTAAAAGTTTTTATTTGCAAAGAAAATATCTAATAAACAACAAGCTAAACAAATACTATTTTGACGATAAAATGTTAACGTTATATGATGAAAAAAAACTAAAAAAATTGAAAACGCTTATTAAGAGATGGGAAGTCTATGAATCTCTAATTAAGAAAAAGATACTCTTTTATTATGCACTGGGTATAATACATAAAAGATTGCAAAAGCTTGTCGAAAAAACTAGTGAAGAGATAAAAACTGCACTCGGTTATCAAAAAATAGTATACAAAGACATAGATTTTATAAAGAGTTTTTGTGAAGCCCAAAGAATCTATCTGCAAAAAACTAAATATGATTTTTCAAATGAAATGTTAAATTTTTACGATGAGAATAAATTACAGCTCTTGCAACAAATTATAGATCATAAAGGTCCCCATGACCATAAAGTAATTAACGAAATTTGCTCAAAGATAAAAAAGAATATTGGTTATAGTCAAAAAGTTGACGATGAACTGTCTTTTGTAGAAAGTTTTTACTATACCCAAAAAGAATTTTTATCAAAAGAACATCGAAACGAGACTTAAGATAGTTACATTACTGGGACCACTAGAATCGATTTGTTTGGTACAGATTTCGTAGGATATCCTTGGAAAATTCAGAGCTGTTTTTTTAGGCGTTGAAGTACACCCCTGCGTCAAGACCGTTTTAGAAAAAAATAAGAGATAGTACTGAGGCCGTTACGCTACAAGCTATACAAAAAGTGCTTACAACGCCTTCGGCACCAACAGCTATTTGGGAAAAGCGAGTGCATAGTTGCTATTCCTTAATTTTTGGCGGTTATACTGAACACCGAGTTACAAGAACAGGTAAAGTTTACAAAACAGCGTATCACTACGCCACGAAAGTGTGTTGATCAGCGATTCTATTTTTGAGCATGATAAAATTTGGTCGGTTGAATAGATGGTAAAACGGAATTTCTTCAATTTTAAAACCAGCTTTCTCCAAAGGGCAGGCCCAAACCTCACCGAAAAAAATCACTTCAAAATTACCATTTTAATTACAGATAACATAGCAAATAGAATGCAATGTTCCAAACGTACTTGATTATAAAAACGTTATCTTACTTAAGACTTATCACCGTCAGATATTTACTGTCGTATTAACAATACAATACTTTTGTATAAAACAAATTTACAAAACATCATCATTTTTATCCCCAAGAGCCAAAGACTCCCGATATTCTTTCGCTTCGGCAACCATAGTCCAGTGTACTTCTATTCCCATTTCTTCGACAATTTCACGAATATCCTTTAAGTTCACTTTAAAAAACTCTTTGCGATTATTGATTTTGTTTAGCTGATGCGAAGCCAGCTTTTTGTGGATTTCATTTTCGAGTGCTGGAGAATCTTCGCTGTACAGCATTGCATGTACGTCAAACAAAAACGGTACACTTGCATTTCCCAGTTCTTTTACTCGATCGAGAGGATCTAGGCGTCTTGTAAGACCAATTTTAAAAACGTCTTCACCAAATGAGCCAATATTAGAGATGATGTAGACATGGCCTGTCTTTGTCTGTTGTGCCATGGACAAAGCTCTTTGATTCTTTTGTTCTGCCTCTGACAATTTACTTAATAGTTCGTTTAATTCCATTTCATATTTTTGTTTTTGTTCTTCCGATGCTTGATTAAATTTTTTCTGCGCTTGCTCCATCGCTTTTTTTAGCATTCGCTCTTCTTTTTCGGCTTCCTTCATGGCCTTTTCGTATTCTTTTCTGGCTTTCTCTTCTTCACGCATAATTTCCTTGATTCTTCTTTGCTCTTCTCTCTCTTGCAGTTGAAGTTCATTAACAGCAACGGCCCACTTTAATTCTTGCATACGATTGTTTAAATAGTCGGGTTCTATTCTTGCGTTGCGAAATGCTTTGCCGTTGTGATTCACTAGATTATAGGCATCTGTGATTTGCTGTTTTAGCTTGCCATAATTATTGTGCTTTGTTTTCGTAAGAATGGTATCTACTTTTCCGTTAAATGCATCCAGTACAAAATTAATCGCTGTCGTTTTTCTATGTGTTTCGACATAATCGCACTTTGCCGCGATTCCATTTGTCACCATACTTTTTGTTTGAGACCTGATCTTTTTTAACTCCGCACCTGCTTCTTTATGGCTAAAGTCTTCTGCTAACTCATCAAGCACTGTGTTATTTGGAATAATATATTGATCGCCATAGCCATCGATGATATTTTTCATTGCTTTGGCTGTTTTCTCATAACGATCTGAATTTTCTTTGGCCTTAATTGCATCACCAGCTATTTCGATGGCCCGATCTTTTGCACTTTTGACAATGCGCTCTGACTCTTCAATTGCATTGTCCAACATTTCTTGTGCTTTTTGTTTTTGCTTGTCGGTTTTTTCTTTTGTTTCTCTCTTTAGCTGTTTCGTCTCTTCCTCCACTTTGAGAGTGAGGTTCATGGCGTAATTTTCGGCGTCGTCTTTGATCGCTTTAGCTTTTAAATTTGTTTCATGAACAAGATTTTCGCATTTTATTTCGTAATCTGTTTTAGCTCGTTGCGCTTGCAAATGCATTTGTTTTATTTCCGCTTCAACATGAACTATCTTTTGATACTTGTAAAGTGGCTCTACACTTCTTTTCAGCTTGTTCATCGATTCAATACATGACTCAGCACGTTTTCTCTCTTGGTCATATTTTACAAACATCGCAACTACAGCTACCGCCATGGCTAAAAGTAATATTTCCATTTTTGACTCCCAAATGTATTTAGCAAACAAAAGGTTAAACGATAAATAGATTTGTTGAAAAACTTCTCTGCGTACTCTGCTCTGTGGTTCATTTTTATTCGTTATATTTAACGATGACCACCAAATCTGTTAGAGTGAAATTTGTCACACTATAATTTATTTAAAACATCTAAAATATTTGACAAAATAAAAAAATAGTATACATTTGCTAAGATCGAATACCAGAAGAAAAAATAGAAGACCAAGTAAGGAATTTTTGAATGAGAAATTTGATAGCTTTAACACTCGTGATGTTTTTTTCTACATCACTATTTGCCAACAATTGGTTTGAAGAAAATATCAATATTTTTAATCGCAAAAACAAATTGCGTAAACTAGGACGTAATCTCGACAAATTCGTTGCACAAAGAGCGATTGAGCGCGCAAAATTTTTGGGACGTGAAGTTGATAAAAAACTATTTCAGCCTATTCTAAAAACGTTAGAGTACACTGTTCCTGGCCACGGTTATCTAAAATATTTGAGCGATCAAGCTAAAGACAAAAGAAAATACCTACCACAAGAATTTATTCGCATAGTTCAAAAACATTATCGAAGTATCGATCTACAAAAAGTCACATATGCCGAAGACATTAACACCGTACACGGAGATGCGATCACCATTGGCTCCGAGATTTATTTTCCAACACGTGTAGATCTGACAGATGGAGATGACGTTTTTTGGATGCTGCATGAGCTTGAACACGTAGTTCAATACAAAAAAATAGGAGTGTCTACTTTTCTGGCCAAATATGTCACTCAGAGTATTAGCGAAGCTCTCAATCAAATTGTAAAAGGCTCTTTTTCCGTTCACGATAATATGCAAATTGAAATAGACGCCGACAACAAGGCAAAGAGAATTTTTGCGGATGTGATGCATAAAATAGAAGTGGTTGTTCCGACGGTCAAAAAAGAGAGTATTAATACTTTCAAAATTAAAAACGTGAAGACTGGTGGATATTTGTTCACACGCGCAATTTTAGCAGCGCGTTTTTACGGTGGTGCAGGAGATATCTGGCAAATTTCTTACGCGGAAGAGCAAGGAAAAGAATACGCAACCATGCAAAATGTGCGCACCAAAAGATACCTTTATGTCGAGAGAAAAGACGATGGTAATCATGTAATCAGTGCGACACAAAATATCTCACCTAAAGATATTCGTTGTCAATTTTTTATCGAAAAAGCACAAAAGGATCGCGATGACGGACAATATTATATAAAAAGCCGCAAGACTAAAAGTTATGTCTATATGAATCCTGATCAAATTGGTTATATATCGCGTAGAATTATGTTAGGTGACATACCACAAAAGAAAGAAGTTGCAATTTGGTATATAAAAGAGAAGGAAGCCCACACATATAAACTCAGAAACGGACTCAAAAAAAATATTGGTCATAGTGGATGGACTATAAGCATAAACAATATGAAAATTTCCGACAAATTAGAGGTTGTCTGTGGAACAGATTACGCTGATCCTCGTGATACACTATGGCGTTTTCAAAAACTAAGTGGCACATTGTGTTACAAGATACAAAATGTAAAAAGCGGCGGCTATCTTGTAAAGGAACCCTCTTGCGGTAAAGTAAAGATTTCCGTTGCTCCACACATAGACAAAACGCGAGAAAAGAATGATTACTATTATAGTTATATATGGTACGTAGATCCTAGTCCAAATGGTCTACAGATTGTGTCTGTGCGCAGCGGACAAAACTTTATGGACCTCAATGCCAGAATACGCAAAACTAACGTAAATTACCACGCGTATAGCGCTCTTGCCTGTGAAAGTATTACCAGCAAAAAAGACTTTGCTACCGCACAAAAAGATATTAAATTTATGAACGATCAGTATGAAGGTGGAGCGCGCATTCCCACGTATCATTTACACAATAAAGACAAAGTCGTCATCGAAAAATCGCTTAATGGTACAGGAGGAAAACCAGTGGTGGTAGATATCAAAAATCGTTGGTATTTTTGGGAAACACAAGGTGTTAGCATGCAAAAAGTAGGCAAATCTCAAAAATACATCGTATATGCTAAAAACGCCACTTCTTTTCCAATCGATGTAGCACTTGCTTACAAAAATAAAAAAGGCGCTTGGGTACGTCATGGTTGGTGGCCGTTGCGACCTGGCGAAGAAAAATATCTTGTTACGACACGGCATCGCGATTTATATGTACATGCTGCGGGTAGGGGAAGAATTTGGGGAAAAACGCGCCCTTTATCCATCTCGTATAACAATTTCAAATTTGTGGGCAAAAAGAAAAGAGGAGATCATAGCGCAAAATTTACCAAGGTATTGATGGATAGGCCTTACTATACCTACGTCTTTAAACATAAAACTGCAAAAGTAAAAAAGTAATTGTCGCGCAACATATATTTTGTTTTTGCAAAAGTACTGCCGAATTCTCTGTCGTATTGACAAGTAGTAATAGGAGCTTGACTAAGTCAATACCTACCATACAACGTCTCAACGGTGATTTTGGGAGAAAACTCTATGCGGCAGTACTTTCTTATCTTTTCATTGCTACTATCTCTGACGTATTGTGACGACAAACAAAAAACTCTTGATAATGCGATTGCCAATCTACGTACACGCAATTATCTACTACGTGTAAATTCCATTAAAGTCATTGGTGGATTTGGTCTAAAAGCACTACCAATTCTGTACAAGCAGTTTTTTTATGAAAAAGCACTAATACCTCAATACATCGAAGCTTACTTAGTGCAACAGGAGATTATCCGCCAATTCAGACGTATTGGTCATGCCGACGATCGCGTTGTTGATTTACTAAAGAATATTGTCAAAGAAGATGATGACTTTTTGGTAAAAGAAGCGATCTTGGCGTTAGGGGAGTTGGGGAAAAAAGCACCAAGAATAATTTTTTTTCTAATAAAAGTACTTGATGATCGCTGGGGCGAGTTGGCGGCTCAATCGTTGGCAAAGATAGGAGAAAAGGCGATACGGCCTCTAGGTAAAGTAGTCCGCTTCTCGGATACCCCTGAAGCACGTTGTGCAGCTGTGAATGCTCTTGGGGATATCGATTCCATAAAACACCCGATGCTTCGTTATTTAATGGATGCTAGCAGACACGACCCCAATGAGTTAGTTAGAGTGGCCGCAGTTCACGCCCTAGGAAAGAAAAAACACACATTAGCGACTTATATTTTGCTACGCCTAATTCAAGATGAAGCACAAGCCGTAGGACTAGCGGCATGTGCATCGTTAGCAAAACACGGAAAGCTCGCCGTCAGCCAAATTATGGATACTTTTGACAAAAATCCCCCCGAACAACTGCGTATAAAACTATATGGTATTCTCACAGTAATCGGTAAGGAAGCAGCCCCCGCAATCGCGACTTTAAACAGTCGTTTATCATCTTCCTCGCAAAAAGAGTTCCAGGCAATTATTGAAGCGCTAATATCCATCGGCTATCATAAAAAATCACAGCAGACAATAAAACGCCTGATTTTTGTTGTCTATGAACAAAAAAATAGCCAGACGCTTTCTCTCATTACAAGCGCACTGCAAAGCTACGCGCCGCAAAGTCTACCGCATGTACTGCCCCTTCTTAAAAGCAAACGTCCACAAGTTGTCAAGGTCGCTGTTCAGGTGCTCGAAAGTCATTTTGTAGATGCGATACAGTTATTACAAGATCAAATTACCAAACAAAAAAATCCGGTATTTATTGCAAATGCATTGAAGATTTTAGCCCAAGATGAGAACTCTCTGCCCATATTGATCGAACACTTGCAGCACGAAAATTTGTTGGTATGTTATACCGCCAAAAATATGATTATACAGCACTTCTCCAAAAGTGCTTTTGAATTGCTCATGAAGCGCATCGAAAATTTGACGAATCACATCAAAGCTCTAAAATCAAACCAAGATAAATTGCAAAAATCAAAAGTCATTGTCGACACATTTGTCGATCTTGGCGAAAAAGCCAAAATTGCATTGATGAATCTCGCGGTACACGAAAGCCCATCACTGAGACACATGGCCGTGGATGCCATTGCGCAGTCAAACAGTTTTTTTGTTGAAGAAAAAATCGCGATTTTCCAAGCAGCGATCCAAGTACGCCGTGGAACAGAGCAATTTGTGATCACAAACCATCTCGCAAACTTGGGAGAACCCGCGATGGAAGCAATACTCGAACTCCTCACTTCGAAAGAGTTGTCTGTACGAGAATGTGCGATTATTGCTCTAACAAAAATGAGAACACCACGTGCAGCATGGAATTTGATCTGGTGTTTAGATAACAAACAGAATACCAGCTTTGTGATCAAGGCGCTTTGTGCTATGCATGATGTCGCAATGCCGATACTCAAGAAAGCTATTTCCCACGAAGAACCCCATGTGCGGTTTGTCTGTGTTGTTGTGTTGTCGAAAATTGAATCACAAGAGTCCATCGGCGTATTGCGCAAGCATAGCGATGTCGAAACACATCCGATGATTAGGTATGTATTGGAAAAAGCTTTACAGCAAAAGGGAGATTAGGCTGTGATGAGTGTATCGTTTATGGATACGATTTATTTTAAAAGGATTCAACAATTGCGAAGTGAAATATCGCAGCTGTAATATTTCACTCCACCTGTTAGGACCTGAATGTATTCGGGCATGATTTATTGAAGTCTAGATAAATGCTCGGCTTACACCATTCTGACAGTATCTCCGAACTATTTCTCCTTGTTAAATGAGTAATCATTATAGCACATCTTTTGCCATCTTGGTATAATTTTATTGCCACCTTTGCCACCTTTGCCACCTTTGCCACCTTTGCCACCTTTGCCACCTCCTTGCCATCAAATTAGATTTAACTCCAACTTAAGGTGCTTTGTTATTGCAAAACGTTTCTGGGAAAAAGTTTTTAGTTAGGATTTGGGATGAAAAAATTCGTACTACTCACTGTTTTTTTGTTTGTGTACTTGATAGCTGAAAATAACCATTCGCAACAGGTAGTGCAAAAATGGATAGATCAACTACAAAATGGGACTAAAAAACAAAAGCTATCAGCCATAAAAATGCTAAAAGAAATAAGTTACAAAGAGAAGCTGGACACAGACATTGTAAAAAAAATATGGGATCAAACACTAAAAGAAGACGATAATGAACTAGTTATCTTAATTCAGAAAATGGTTCGTAGCATTGAAAAAAAACAACTTCATTATAAACATACTAGTATCAAACCCAAAAAAAAGAGCTATCGTGCGGACCCCTCAAACTTAACAAAAAACCTCGGTGGTATAACGGTTCTTGGTTCCAGCAATGACTTCCCTTCAAAACAAAAATACGAAAATTGTTATGCTATTGTTATTGGAATCAATGAGTACGACAACTTTACAGACTTACAAGGACCGAACTTTGATGCATCTGAAATTGCCAAAGTGCTAAATGATAGATATCAGTTTAAAAACATCCTCTTGCTTACAGACAAAGCTCCTATTGTCTCTCGAGAAAATATAGAGGTTAAGCTAGGAAAAGTAACAAAAGAGCTGATCGAAAATAGTATTAAGAAGCTTAAAACAAATAAGATCAAATCCAAAGATGCTTTGTTCTTTTACTATGCTGGCCACGGTGTGCCAGGCTATATTGTCGCTGGTGACAGTCAAAAAGTTTTAAGTTCAGGTCAACCAGCTAAAGAAACTATGATTTCTCTAACAAAGATTGCTAAAAATTTGGAAGTTTTAAACGCTCGGCATACCTTGATGGTATTGGATAGTTGTTTTAGTGGCTCGCTACTAGAAAAAGAACATCGCCCCGATTTTTCCCACTTAACAAGCAAAGAGTTTGTTGATCCAGGAGGAAATAACTTAACCAGAGTATTTAATCGCCGGGCTTTTCAGGTAATCACTGCTGGAGCAGGGGATGAAGTTGTTGCCGACAAGTTAGACGAAATTTCAACGGTGTATGCACAACAATTTAAAAATAGCAGAGGCCATTCGCCATTCACAGCAGTATTTTTACAAGCAATACAGGGGCTAACAGGAAGGGATGATGGAATTATCCTGGCATCGCAACTCGGCTTCTACATGATGGACACACTGGTAAATGATGATCGCATAAAAGCATCTCAGGCACCACGTTATGAAAATGTTGGTGGCAATGGTGATTTTATGTTTTTTCCTAGCGAAAAAGTACTCAATCCTAAAATGGTTGCACCTTTATACCTAAATGGTATCGAATTTGCTGTGTTTCGGCGATCAGGTTGCGAAGCTTTAAAAAATTTCATTCATGACCAGAAAAACCAAAAAGAGAAGGCTTCCCTTATAAAAAGTGCTTTACCTCATATTGCGAAATTATTAGAAGATAAACAAAGTATTCCATGTGTAGCAGCGCTAAAGTTTATCAAGCATATGACACAAGACTATGCTGAGGTAAAAGAATTCTCGATAATTGTACCAACTCTAGTAAAAATTCTAACCCAAAAAAAGAATCCTACATTTTTTTCTATGGAGAGTAATACGCATCTGGCTATTGAATGCCTTGGGTCTCTATCCCCACACATAAAAAGTGTAGAAACAGTGGATATATTGAAAAAATACCATCAACAACAAAAAGCAAAATGGGAAAAACAGAGAAATAGATTAAGGCCAGAAATAGTGGAGATGGAAGAAGAAAAATTAAAAAAGCAAATAAATAGAAAATTGCTATCACAACAAGCAAACGATTACTACGAAAATATTAAGATATATTATTGGTTAAATAGTAAAGGGGTAGCAGAACTAGATAAATATGAAGGGCAAAAGAATTTATTTTTATCCGTTGCAGAAAAAGATACACAAAAAAGACTAGATGCTTTTGAAGAGCTAAAAGAAAAATTGGAAGATCAAGATTTTATAGACTACTTCGTCACCAGGGATAAAAACATAAGGAAACAAGTTTTAAAATTTTTAGAAAAAGACAGTAGAGATTTGGCCATTCTTTTAGAACTGCTAGCAAAAAAATATAATGCGGTAAGATTTGATGTAGCAAAAGATCTTGAAATGATAGGAGAAAGGGCCTTTCTTTCCATTATCAACAGACTTGCTATTGCAAAAGACAAAAATAATCTATCCTCAAAAACCCATCTTTTATTGCCTTTTGAAAACTGGAAAAAAAAATCGTTATTTTCATTTATTTCGAAACTAGATAAGGAAGAAAAAAAGTTTTTTCTTCCTTATCTAGTAGAAGTAAATTTTGAAAATCTGTACTCTGAAGCAATCAATCCTGAAATTGATGAAGAAACGAGGTTGGCAATATCTTACCTCCTTGGAGAAAAGGATGTTCTAGAACCTTTTATTGCAAAATTCTTTCTTTCTATAAATGCAATAGATGCACTTGGTAAAAAGGCAGCTATTCTTACAATTTCGCAAAAGAAAAAATATAAATATTCAATTGTGATGATTTTTAAAGAATTACTAAAAAGTCCAAACAATGATGTAAGAAGTTCTGCAGCAGAGATATTAGGACAAATAGAGAGAAAAGCTGAGGAAGTAGTACCAGCTCTGATCCCTTTGTTACAGGATCAAAATTCAGGTGTAAGAAGCTCTGCAGTAAGTGCATTAGGGTTGTTCGGAAAAAAAGCTGAAAAAGCTGTACCTTCTATTGTCTCTTTACTAAAAGATCCAGATGAAGATGTGAGAAGGAAGACAGAAAAATCCCTAAAAAACATCGGAACAGCAGAAACCATAACAGTCTTCATTCAGTTGTTGCAAAACCAAGATTCAGTTATAAGAAGCTTTGCAGTTGAAATATTAGGCAGAATCGGAGAAAAAGCTCATTCTGCAGTACCCGCTCTTATTCTCGCATTAAAAGATCAAGACAGTTGGGTAAGAAGTTCTGTAGCAGAAGCATTGGGAAAAATCGGAGAAAAAGCTCATTCTGCAGTACCTGACCTTATTCCTTTGTTGCAAGACAAAAATAGTTCTGTGAGACGTTATGTAGTGGAGGCATTGGGGAAAATTGGGCAAAAAGCTCATTCTGCAATACCCGCTCTTATTCTCGCACTAAAAGACAACGATGTGAGAAGTTCTGCCGTAGAAGCATTGGGAAAAATCGGAGAAAAAGCTCATTCTGCAGTACCTGACCTTATTCCTTTGTTGCAAGACAAAAATAGTTCTGTGAGACAGCATGTAGTGGATACATTGGGGAAAATTGGAGAAAAAGCTCATGCTGCAGTCCCCGCTCTTATTCTCGCATTAAAAGATCAAGACATTTGGGTAACAGAAGCATTGGGAAAAATCGGAGAAAAAGCTGTGCCAGCTCTCATTCTTGCTCTAGAAGACGAGAATAAATATGTTAGAGCATATGCAGCACAGGCACTGGGAGCTATAAGAGAAAAAGCTCAAAAAGCTGTCCCCAACCTCATTTTTCTTATCAAAAATGGGGATGAAAATACAAAAGAATTTGCCGCACAGGCACTGGGGAAGATAGGAAAAAAAGCTGTGCCAGCTCTCATTCTTGCTCTAGAAGACGAGAATAAATATGTTAGAGCATATGCAGCACAGGCACTGGGAGCTATAGGGGAAAAAGCTGAAAAAGCTGTGCCAACACTCATCTCTTTGCTACAAAATCAGGATGAAAATGTGAGGAGAAATGTAGTTGATGCATTGGGACAGATAGGAGAAAAAGCGGAACAAGCTGTGCCAGCTCTCATCGCTTTACTAGAAAACGAAAATGATTTTATCGAAAGTGTAGTAAGGGCGCTAGGAAGAATAGGAGAAAAAGCATTTTCTTCTCTTATCCTTTTATCACAAAAGCCAATATTGCAAGCGCAAGATTTCTATATAACAGTAAATGCACAACAAGAATTGAAAATTATAGGAGAAAAAGCTGTACCAGTTTTTATTCTATTGTTACAAGACCCAGATTCTTATGTTAGAAGCTCTGCAGCAAAGGCACTAAGAATAATAGGAGAAAAAGCCGAACAAGCTGTACCAGCTCTGATCTCTTTATTGCAAGACCAGGATTCTCAAGTGAGAAACTCTGCTGTACAAGCATTAGGAGCTATAGGAAAAAAGGCTGAAAAAGCTGTGCCAGCTCTCATTCCTTTGCTACAAGATGAAAATGTGAGAATGAATGTAGTTGAGGCATTGGGAGCTATAGGAAAAAAGGCTGAACAAGCTGTGCCAGCTCTCATTCCTTTGCTACAAGATGAAAATGTGAGAATGAATGTAGTCGAAGCATTGGGAGCTATAGGAGAAAAGGCTGAACAAGCTGTGCCAGCTCTCATTCCTTTGCTACAAGATGAAAATGTAAAAATAAGTGTGTTGGAAACATTGGGTCTGGTAGGAGAAAAAGCTGTGCCAGTTCTCATTCCTTTGCTACAAGATGAAAATGTACATATGAGAATACTTGCAGCCAGGGCATTAGGAGCTATAGGAGAAAAGGCTGAACAAGCTGTGCCAGCTCTCATTCCTTTGCTACAAGACAAAAACAGGTCGGCGAGAGCCACAGCAATTAGGACATTGGGAAATATAGGAGAAAAAGCTTATGTAGTAAGTTCTTTTCTTATTCCCCTATTAAAAAAGGATAAACATGAGAAGATAGAAACAATCCGGGCATTGGGAAAAATAGGGGAAAAATCTCATACTGTGGTACCTTCTCTTGTTAATTTATTACAAGATAAGAATTCAGATGTGAGGAGGGAGGCCTCTGTAGCGTTGAACGAAATAGGAGAAAAAGCCTTGCTCTCTCTTATCCCTCTATTGCGAGAAAATATACTTGTGAGGAGTCAGGCAGTCCAAATATTGGGAAAGATAGGGGAAAAATCTAGCACAGTGACCCCTTTTCTTATCCCTCTTTTACAAGAAAAAGATGTAGGTGTCAGGGGCTTTGCGGCAGCAGTGTTGGGAGAAATAGGTAGAGATGCTGTTTTTTCTCTTATTCTTTTACTACAAGACAATAATCAATATGTGAAAAGGGAAGCAGCAAAAGCATTAGAAAAGATGGGAGAAAAAGCTGAAAAAGCTGTACCCACTCTTATATCTCTACTACAAGACCAGGACTCAGAAGTGAGAAGTTCTGTAATAAAAGCTTTGGGAAGTATCGGAGAAAAAGCTGAAAAGGCTATACCAACTCTTATATCTCTACTACAAGACCAGCACGCAGAAGTAAGAAGTTCTGCAGCCAGAGCATTGGGAAATATAGGAGAAAAATCCATACCGATTCTTACCCCTTTGTTGAAAGATTCAGATAAATATGTTAGAAAAAATGCGATCAGAGTATTGGGAAATATAGGAGAAAAAGCAGTTCCCACTCTTATTCCTCTATTGAAAAGCCTAGATAAATATGATAGAAGAAATGCAGCAGAAGCTTTAGGACAGATCGGAGAAAAAGCTGAAGAAGTGGTGCCCATCCTTACTCCTTTGTTAAAAGATCCAGATAAATATGTCAGAATGTATACAGCAGAAGCTTTAGGAAAAATCGGAGAAAAAGCTCATACTGCTGTGCCTGACCTTATTCTTTTGTTACAAGACAAAAATAGTTATGTGGGAGTGCGTGAGGTGGAAGCTTTAGGACTTATAGGAGAAAAAGCTGAACAAGCAGCACCAGTCCTAATTTCTTTCTTACAGGAACCAAATTTAGATCTGAAATTTTCTGCTGCAGAGGCATTGATCCAATTGGGAAAGGTAGAGGAAGCAATACCAGCCCTTGTTTCTTTAATAAAAGAGGAAGACTTTTTTGGGAGAACATATGCAATAAAAACATTGGGTAAAATCGGAGAAAAAGCAGAGAAAGCTGTACCAACGCTTATTTTATTACTCAAAAATGAAGACTGGTTAGTGAAAAGCTCTGCTGCAGAAACATTAGGAATGATTGGAAAAAAAGCAGAAAAGGCCGTACCAACTCTCATCCTATTACTACAAGACGATAATAGACATGTAGAAAAATCTGTAGTTGAGGCACTGATACGAATAGAAAAAATATCACCTCTCATTCCATTATTACGAAATAAAAATTATCATGTAAGATATTCTGCAAAAAAAATACTGATAAATATAGGAGAAAAAGTACTTCCCTTCATTAGAGAGTTTGTCCAAACAGAGAGGAATAAAGCAACTATTGAATCAGGTCTTGCAATTTTAAATAGATGTTTATGGAATGCATATTTAGAAGAAAAAAAAATCTTCCATCAGATGGACATAGAATTATTATCGCTGTCTAAGAATAAAAATTACTTTGATACTGTAGCAACAATTTATGCTTGGCAAGGAAATGCGAAAAAAGCATACGAATACGCAGCCAAAGCTATAGCAGAAACCCCAAAGAGAGTAAAACTACTTCTAGAAGGAAAAGCTCCTAAACAGGTAGAAGAAAATATGAAAAAAAAATAAAGCTATCCGATTTCAAAATGTAATTTTGAATTGATATCAAGTTTGTGCCAGACCAGTTACAGAACCATAGTCGCTTTAATATTTATAGCTTGATAGTTTTCGTAACATAAGATTTTTTTGTTGCGAAATCTACTTGGAAAATACACTGCGAGAAAACGCTATGTGAAAATGTGGTATTAGTCAAAATATAGTGCCAGACTGAGCCTATGAACCCGATAAAACCGTTCAATAAATTAGCATACAGGAGAGTGCTATTAGTGAAATGAGATTTCTTGTCGGATGAGTATGTAAAATAGCGAAATAAAATTTTATTAACCATTTTACATATCAGGAAAAAGAAAGATGCGGCCAATAAGAATATCAATGATTAACGGTTTATTCCATATCACCACAAGGTGTGATAACAAAAACTTCTATTTCCGAGAAGATGAAGACTTCATAGAATATCTAAAAGTTGTAGAAAAAGCGCGACAAAAATACGGTTTTAAACTTCATGCTTACTGCATCACAAGTAATCACGTTCACTTGTTAATTTCAACACCAGCAGAGGATAACCTGTCAAAACTAATGCAGTATATCAATGGGCAGTATTCAAAAAATTACAATCGCAGGCACAAAAGAACAGGGCACTTTTGGGGAGAGCGCTTCTATTCAACTATCATTGAGTCGGAGAATCAGTTACTAAACACAATTTTTTATATTGAGTTAAACACCCCACCTCAATAA

Protein sequences of DBSCAN-SWA_4

>NZ_AP019860|6514664:6589538|6551380_6551566_-|WP_151970388.1|DBSCAN-SWA
MKEKGILLGEMQAKLLQKIEELTLYTIEQEKKIQQMSKEKIKMENKLLRRIEKLESAVKNK
>NZ_AP019860|6514664:6589538|6575893_6577459_-|WP_151970399.1|DBSCAN-SWA
MEILLLAMAVAVVAMFVKYDQERKRAESCIESMNKLKRSVEPLYKYQKIVHVEAEIKQMHLQAQRAKTDYEIKCENLVHETNLKAKAIKDDAENYAMNLTLKVEEETKQLKRETKEKTDKQKQKAQEMLDNAIEESERIVKSAKDRAIEIAGDAIKAKENSDRYEKTAKAMKNIIDGYGDQYIIPNNTVLDELAEDFSHKEAGAELKKIRSQTKSMVTNGIAAKCDYVETHRKTTAINFVLDAFNGKVDTILTKTKHNNYGKLKQQITDAYNLVNHNGKAFRNARIEPDYLNNRMQELKWAVAVNELQLQEREEQRRIKEIMREEEKARKEYEKAMKEAEKEERMLKKAMEQAQKKFNQASEEQKQKYEMELNELLSKLSEAEQKNQRALSMAQQTKTGHVYIISNIGSFGEDVFKIGLTRRLDPLDRVKELGNASVPFLFDVHAMLYSEDSPALENEIHKKLASHQLNKINNRKEFFKVNLKDIREIVEEMGIEVHWTMVAEAKEYRESLALGDKNDDVL
>NZ_AP019860|6514664:6589538|6579990_6581994_+|WP_151970401.1|DBSCAN-SWA
MRQYFLIFSLLLSLTYCDDKQKTLDNAIANLRTRNYLLRVNSIKVIGGFGLKALPILYKQFFYEKALIPQYIEAYLVQQEIIRQFRRIGHADDRVVDLLKNIVKEDDDFLVKEAILALGELGKKAPRIIFFLIKVLDDRWGELAAQSLAKIGEKAIRPLGKVVRFSDTPEARCAAVNALGDIDSIKHPMLRYLMDASRHDPNELVRVAAVHALGKKKHTLATYILLRLIQDEAQAVGLAACASLAKHGKLAVSQIMDTFDKNPPEQLRIKLYGILTVIGKEAAPAIATLNSRLSSSSQKEFQAIIEALISIGYHKKSQQTIKRLIFVVYEQKNSQTLSLITSALQSYAPQSLPHVLPLLKSKRPQVVKVAVQVLESHFVDAIQLLQDQITKQKNPVFIANALKILAQDENSLPILIEHLQHENLLVCYTAKNMIIQHFSKSAFELLMKRIENLTNHIKALKSNQDKLQKSKVIVDTFVDLGEKAKIALMNLAVHESPSLRHMAVDAIAQSNSFFVEEKIAIFQAAIQVRRGTEQFVITNHLANLGEPAMEAILELLTSKELSVRECAIIALTKMRTPRAAWNLIWCLDNKQNTSFVIKALCAMHDVAMPILKKAISHEEPHVRFVCVVVLSKIESQESIGVLRKHSDVETHPMIRYVLEKALQQKGD
>NZ_AP019860|6514664:6589538|6548302_6548833_-|WP_151970386.1|DBSCAN-SWA
MDFFSNPNITLIDKLIVFAYRNEGMEPEKVIRSVGAEDHIYYYNGYWTQYGEEITITRAAYKKVLAKYNVTSENVRENARVLSAVGDVSTKLTVLEQQVKVLLACIKKNFSMQLTFNEKSGREVVRISRKGNNTWIHLNEKENDWLNGVCQLPGWCKNGTYWTKTVQNWDLCGSAV
>NZ_AP019860|6514664:6589538|6552879_6558009_+|WP_173013517.1|DBSCAN-SWA
MKTLFSQSQITIKKLRALTTKTTLSVWRKVLFIVMVFLVNNVAFAQESNEKLHEIFIALCSDHQQKSTAAMHELIMLSKNSPTLTRVLQKIAIQDSREWIRTLAKNALQSSSQSVQKLIDDLYPTEKTRASGLHKSKSLGGLTILGASHDFRQRLRYGKKHALVIGINQYEKYSDLQGPNFDAAAVASVLVRRYGFDDVVLLTDTSPQNIYRTTEKWSIRAVNKQTIADYLAMLRSGKERGNYKVRLSQVDKDDALFVFFAGHGIPGYIVAADSHNESTAISLRWLAEELAKCRAQHTFLVLDCCFSGSIFSPPFRPRLGAFDVKMDFHRGENIDRVFRRRCFQIVTAGTGGEVVADQLRLSSIYAQKNRNLRGHSPFTAIFLQALEGLVGREDGIVLTSDLGYYMGTTLVNDRRIDALQTPRYQSLGGDGDFMFFPAHKVLNPRLLQMLYLDEQKYAEIKRSTCAAIQKFILEQPRNDHLPLTRSAVIHMSKLLEESQFLTYQGAVQFIYNMLHEQKMDIAQIPEYSSVVLPLANLLDKTLSATKSPQRTQIMRKISYCLAALDLYTNEIAVNALREYIHFQDAEWKKYRQTRHIPTSVLLYKEKLSKLRITAESLSEQMRIYAKKNAIYLWLHTKGRQQIEEYQHNLVQSRSLAQTVLQKAKEAYQQKKWEQCGAYAGKALQVVKEYPPLHSLRQKAHTYVRLSMWHSATLWKKYSHSKSVFGQNAAKNAHRAQIYALKYSHNSQTLASASYDESIKLWRAQDGVFLRDIFPTMQHQPLQIEASSKANILAILTGGGFIEVYDLVLKKLISTIKIGKVERPIMAISSDGKTIALSDQSEKITLYSVARAKKQRELVGHKDDVTTLAFSPDNQWLASGALDHDICLWNLQNNRNKILSAHKNAVIQLSFSYHGELLASCSQRNTLVWDLKKHQVDLIIPVTRYQRFTAVAFSRDDRLLACGTSKNIELFDIAAAKLTLQIPTKMHSSFLCFHPSGKILLAHQHFLGAVVAWDSKNGKKLYTITSDARTTSMKARFSADGKSVIVSARGIEKNIQFFDALNGEKQKPPLKEWFRHVILPKKMAFGKRLLATSSKEGTLIIWNAKTAEAQHIIYEKNIDKLTFSSDDSILACTVHKQIYLYNTDTGKLLHKLPGHQNKINSLSFFPTKPVLLSAGNDNKIKFWSSDNGTLLQTLPTQNRGVLTYFCNDQRTLALLSGYENINVQLSDIYSKQSHNYTLNTTKRVYARLLSQNGAILAIDGGDTYEIWDVRNERRLRTSIQKNMRQLALAPDGTTFAYTNAQHTLQLCKIRPLPQRVFLPAKRYQHIAMGSQGKFLAFSSADELGIWDTHTNKLHKSFKGYNGEIKSLALSHDGKILASAGEFQDPLVRLWETTTGKLRHALDPGDKRLDQVAFSHDGKSVGVSVSGNQVSIVLWDSDSGKKRRVISSPNHQSAAQTFLAFSPQQSILAWARDNEIDLWDATSGRRICQVATNNPVNKIFFDATGKNLVLVNPSAIALWNLQQRKVIAQFRDQYINDGALTTTSKYLAAATSNGVQIWDVITGEKIQRFHETRIFDKVAFHPKKPWLTCIDHNAASRIKPQKESLFFYDLAELMQVHTSKNMPRYAAHRKSNLLLVKNAQKESLWNLHNGVKMSKNISFTNAKKIHLPQKYFAYPRQDIPADIIEFALQETPKRFTEQLFGYRVAEDLSVE
>NZ_AP019860|6514664:6589538|6514664_6516080_-|WP_151970364.1|protease|DBSCAN-SWA
MSLPTSVNRSKNPIEMKLDAESFDHMQYKVKIPPRYWLFGFFTYPFWGFFGNVKILVVDEGFIITGYKMAKNTLFFFLTFLLGFAIFHMLLWKVIPIVWVGILGIAGMHGVNTLRVTLGEITLPFTSFSYVKASIDLDDRVKPQVDVCVSMRWKKVRQKFIFPDVEQAESFMALVQKKSIKHTAKARSPFTYSVIVVCSILFWLSSNANEVDSPLSWAICNWFSGHNYFRWSDILWIEPWTLFSTAFIHENWPAFLTSIIAFYFVARRIEISKGRVFLFWHMLLFAVVANVVSLIIYDLNFGGMLGATCGLLAYSWMQKKQLRTHKYLVFYFAIAIWNSIPLLLFLFFQRECKLFTTVDFGVLYSYVSRPFDLSLGTWMHSGLVASFLGGLVRYFWKENRKYFYTAILLLLFYVVAFSVGIKHFRLYLLFCFMYIVEMILLFYLCRSEKTPQVRKTTNTTQSANICNGYNQ
>NZ_AP019860|6514664:6589538|6545455_6546538_+|WP_151970384.1|DBSCAN-SWA
MSYIAKYEDLMSQTFYVDSQSEILLLEQAARLADSHNDIDLGFRARRRMLSITEITAYVDKMLAAYAWCLTQCDQLPDIYNDRDLLWSFKWLVYSLPECSYINKKQIHSIINDMEQRWQKYQLSMHTIHYMRYIVAVTMADRETAKKYYALCQQTSRGEYSDCSSCEHYNSVRYRVFMEEYGQAFAEAKKILDQEHSWWGCSEAPALTPGELIIPALKLGKIKEAQKYHQLGYENVYGNRRFFETLAQHFMYLIYQKDDAECRKLFDKHIPIAFGIHNDFYCFQFYLAATCFFSNTNKDRINVSMPKNFILHNPEQIYGVSDLKYWFMKKTRDLAVAFDERNGNDYYQREMNVLMELLID
>NZ_AP019860|6514664:6589538|6538456_6538807_+|WP_151970380.1|DBSCAN-SWA
MDEGIVIAGNKIRGGFILTLLSFAFIVSMFLLLALTKIGYLWIFIIAVLISKMIELLRKTQSEITAPYPSIIAMNLKNGKQLKVTVQIRNKKVKQSLFFEKEEALCLFEKIRELLK
>NZ_AP019860|6514664:6589538|6543606_6545274_+|WP_151970383.1|DBSCAN-SWA
MKRVLYLVIFFLPAIAFSQDGLVGKKLLIQGTDADNFFKIRFIGTKPFIETSFDSEFVIHAKVQKDNDNSPIFQFVGIANGGQVKKRSLFRVTNNGHEAMEIKADGHIFSQKLALGTKNPTQRLHVEGGAYIKNYLVTPQIKSDEIGTLSIDIDSKKRKISFFHQNTVLADVLSADVNTVLLRVGGYESIGRSQVGKIISTDFQLIPPDTEKFTNTLSKVYWKDKEEKIVMTLGGGSASEKYVELNATRDLYINTKVGIGIKNPAEKLHVNGAAKFNRVIIGETIFSRSFDNVQQFKIDNAKGNIEIASNYLHLSTPNIHISGTITNMLHVKEGIHTQGKDIYLGANNTDTNHGIGMYHGKYGNHEEKLFAKTNVDGPVVYGYNGGALGTKQEGERIALHWNKDRVQIYKKLDVGSGASIQENGNVYLKGNVGIGVTNTQGSKLAVKGKIVAEEIRVINMEDWADFVFAENYELLPIQELEKSIKNNKHLPGIPSEKEVKEQGIQLGEMQAKLLQKIEELTLYTIQQNKQIQSLQQKNQHLQQEMLQIKKLLQHK
>NZ_AP019860|6514664:6589538|6559814_6561464_+|WP_173013519.1|DBSCAN-SWA
MFKILIATLFFMSMIYAQDICTTLDSGEGFTEQSFEEKEGLSLVGAKNKLWPSNERVLHVRFVGIDNDDIEQQIEEIVEDNWEKCCGIDFRFNNDPKAQITVNITHGVGNNSQIGTDSKTENPSMNFSFYKKNKKGKLYLPKNFFTVVDGKKKIPKDSYEYGTILHEFGHAMGFKHEQQSPRFNIEWHEENVLAYYKKHSPDWTEEDVRHNVLNKLENFRIARNVVTYETEWLFGFIPRVTKKIDRRSIFIINYEATAFDQHSIMCYPLKLELTKNRTEWRLGTLDIDYKKDLDANNYTDSLRKALAKQKDIDVDFTAKITAYKSGYWILQTTLPVNSKLPTSAKVPKKSYRIIEVDGILEVYPALGGGRSLSVMDRYFSNKLYPFPTKTRTHNFVVREVKRAFDEILLRKPTADELSYYVNYMKQNDLLKLRDEVANLAEEKIKNLYFSLAGREPSQEEVKNDKKLLAMENFATLEASTSLEVNLRSREQFGNVAQLQVIGLYSVHAGGSFYVNNNETVEFRAGEEILLQEGFTAKAGSDFTARLYSK
>NZ_AP019860|6514664:6589538|6571578_6571785_-|WP_151970395.1|DBSCAN-SWA
MFIQKDVELLSKSTEKYILDTVAAIYAWQGNAMLAYKYADIAEKETLKRVKLLLEGKTPKQVEQEMKK
>NZ_AP019860|6514664:6589538|6516516_6517044_+|WP_151970365.1|DBSCAN-SWA
MKIGLEIAGSDYIYILPDQNEITIGRQKRKPGQKGNDVVIRVHGNDEASRAISRNHLTLMCRFSGMFICDHSTFGTKVNGQQAMRDKKFAIDVGDRINIADVLTLTVVKLPDSYVDELDVAATTQQQKITLPSVGDCATVAPAFESPVTNNAPASSVGVMSTDVEADVGCFVRKK
>NZ_AP019860|6514664:6589538|6534935_6535304_+|WP_151970377.1|DBSCAN-SWA
MNSQTMITSLAQQCIDHYLTPEQVDFVLQKVDVNPLEIKKSAETRVYYTHIIRYLAPRKKLDEWLIGLEEEGFVFTKDWIGKIRGDDIPMHDTEQKPKKDPALAEAEEGLRILQMLKKKKGK
>NZ_AP019860|6514664:6589538|6518085_6522318_+|WP_151970367.1|DBSCAN-SWA
MMIPVLLFILISVFFICCIYICIKKKVFLRFVLSLTPLFLMMASVAFSQLEDSSTFAHYIIPVTCVANVVIAINFARLAQRNAFYWSIFAFISYGFTNAIMLCFFKGKVYQREEQIRHGLTKWKINYQAILVLFFVYLPFIFLFFFSPKKMEENTQFSFRSPSPENNVQSKMWKNAKQTYFENMKVNKNKRLLVFVIFQIANALFATFVFIKAREGRIKAILVGIIAATITWGLSNFFLVPLWLDTLGQDQNNFGRQNLYWWAIAAPLTLGLSNFTFILSRKKLEPKIFLEIRLLRNRARLYARQRQYTKAEFFYLRCLSVMQNKTLYFETAELMSEIAHLYQQIGEYTKAEQLYTEARSKVDHPIILNKYATWLDEKGEKEKSKKLREEAFQTIKKQINKDPHDEYLLEGLARMYHDSKNYDKSEEAHLEAIQLAKTNVSKLELLSNLASFYVERKLYPRAEDTYIKLIEETQTTLGTHNSIYISLVSDIALLSKEMRKYKESEEFFCENMQVIENVLGKNHLIYIFNHIELANLYSQIGEYGKAEPIYTEILNIVEQMNEKNSFAYASCLNQMGKMYYKIDEYDKAEKYYEKAKQIYHDVLGEYHPEYKACLMNELELYQKQRKSQEVNTLINEIELLNEQQSLCELPENTEVENLQVTISLDVDTLNLIVEQERLKQAQREQQVNEQEIIAAFLQGREENFTNALQMSQNAILLYRKKEYKKALVLQKKASEIIQKTHGKNDRCYVTALNNLAKLYDKTGNYEIASELFSKAVNLRGKILGTEHPDYATSLENLAHLQYRQKKKQSALFNMLKAANVHNKMILRIFSIGDEKRLEKYIDTFEIQYFTLLSIFYQSYKVLHIFSPQVCDLILKRKSLHRELTSIKRDSLFTQQRPDLEESFAKLRQIKLQIAQLILASTDASSTQIAKLEAEKEQLERVLAAEVPELELEKKLTHVSHREIAKLLPADSLLVDFVCFREVDVESMRYLDERYIAIVIYNEQISKELAFVDLGAASEIDELISKYKKHLTTGERKIHVVAEDVLPAENTTVKTQDAYGEQLFQKVFAPVLRKTKDCKRLILSPDGGLCLLPFEVLPQPNERFVVEDYEISYIDSGKDLLRFGYQTAPKSQPVVIANPDFSLSGDQSYTDIRNSIPQSIVAELGQTIQRKVQETKAQYYFPPLAATHKEGVTIGKMLPREYTSLMEEKALDSAIKKLQAPQILHFATHGFFMVDEQQKETDLDEMQDLNESPIFRGEKFRNPLLRSGLALAGANTFFENKQPAPDAEDGLLTALDITGMDLFGTDLVVLSACETAVGEVKIGQGVYGLRHSFIIAGARTLIASLWKVPDEETKELMVGFYRKILRGSEKATALRETQLEMIQKLRDTGKSPDPYLWGAFICVGDPGKMNL
>NZ_AP019860|6514664:6589538|6574092_6575286_+|WP_151970398.1|DBSCAN-SWA
MEYYELEQQRTETKWVWITLMINYIALVYADNLTRTEYGSLAIVVRIMVLTISLSLFMSLGRLGRRTGVGSCLGIFLAIIPFINTLYAFFLLKKSRKLLDRVGIKRSDYSLTAKKVFYDFDTFKKLNKYYFTDEMLISYDEQKFQKIGELLEEWNLYDFFYRKGLLSRLMHYSLRNEKYKKLEETIENISEEIKNAIDYDRPIEKKIYFIKSFYLQRKYLINNKLNKYYFDDKMLTLYDEKKLKKLKTLIKRWEVYESLIKKKILFYYALGIIHKRLQKLVEKTSEEIKTALGYQKIVYKDIDFIKSFCEAQRIYLQKTKYDFSNEMLNFYDENKLQLLQQIIDHKGPHDHKVINEICSKIKKNIGYSQKVDDELSFVESFYYTQKEFLSKEHRNET
>NZ_AP019860|6514664:6589538|6589154_6589538_+|WP_151970403.1|transposase|DBSCAN-SWA
MRPIRISMINGLFHITTRCDNKNFYFREDEDFIEYLKVVEKARQKYGFKLHAYCITSNHVHLLISTPAEDNLSKLMQYINGQYSKNYNRRHKRTGHFWGERFYSTIIESENQLLNTIFYIELNTPPQ
>NZ_AP019860|6514664:6589538|6517059_6518046_+|WP_151970366.1|DBSCAN-SWA
MQAKEVLQLVRDCCDNFLKREEAKHALDFIDVNTSRIPEKEADFDYYREITQYLVSRGKLREWLCVLQQDGLSFTAAWVQKIDELQQSIEFSQKLDQWSLPRTVLTYHDGQKQHKIFLIAKTRVGFGKAKKSQNPDVDITMRVLPLRSQELDPGNWARTKKISQHHGNFVLRNNQFYVERLGKNGIFTLEGNEIEKESLFTLKDTMQIRLAQESLQLKLTTIRDLETQNVNCLCVERVDNHVHHCYVQVIREVTIGGKKADVNLPGMNGAFRIVTAQEGWNVIPDESGYTKINSEVIQEPTLLCNRDVLSTGQQEIVFCMTEDNDFIE
>NZ_AP019860|6514664:6589538|6525351_6525585_+|WP_151970371.1|DBSCAN-SWA
MFKICIALLFLMSILYAQDICTTLDHGEGFTEQSFEEKEGLSLVGVKKLLWPAKERVLHVRFVGIANKDIEQQIPQA
>NZ_AP019860|6514664:6589538|6524313_6525126_+|WP_151970370.1|DBSCAN-SWA
MSNQKIWKCGKCGEEHEYTFDTCWNCGGSIANKQEDQTVSKKLDIMDENKPEYNESIGFENSSESTIEDSHLSPIELESDYTTYSAFIPTKSLFGPVVRYPFWGFFGQVRLMVIDEGVVITGQKMRSGFIFHSLSLAFIIAMFLLLALKVIGHLWVFVIAVSGAKAIEIIRQTHSEITIPFNSFLDISGKGVKKLRTVVQIRRRKVSQILIFDSEGHAADFRNRICNPGAAPANKKTWKCEKCGEEHEYTFDACWNCGKGISENGKTNSL
>NZ_AP019860|6514664:6589538|6582380_6588812_+|WP_151970402.1|DBSCAN-SWA
MKKFVLLTVFLFVYLIAENNHSQQVVQKWIDQLQNGTKKQKLSAIKMLKEISYKEKLDTDIVKKIWDQTLKEDDNELVILIQKMVRSIEKKQLHYKHTSIKPKKKSYRADPSNLTKNLGGITVLGSSNDFPSKQKYENCYAIVIGINEYDNFTDLQGPNFDASEIAKVLNDRYQFKNILLLTDKAPIVSRENIEVKLGKVTKELIENSIKKLKTNKIKSKDALFFYYAGHGVPGYIVAGDSQKVLSSGQPAKETMISLTKIAKNLEVLNARHTLMVLDSCFSGSLLEKEHRPDFSHLTSKEFVDPGGNNLTRVFNRRAFQVITAGAGDEVVADKLDEISTVYAQQFKNSRGHSPFTAVFLQAIQGLTGRDDGIILASQLGFYMMDTLVNDDRIKASQAPRYENVGGNGDFMFFPSEKVLNPKMVAPLYLNGIEFAVFRRSGCEALKNFIHDQKNQKEKASLIKSALPHIAKLLEDKQSIPCVAALKFIKHMTQDYAEVKEFSIIVPTLVKILTQKKNPTFFSMESNTHLAIECLGSLSPHIKSVETVDILKKYHQQQKAKWEKQRNRLRPEIVEMEEEKLKKQINRKLLSQQANDYYENIKIYYWLNSKGVAELDKYEGQKNLFLSVAEKDTQKRLDAFEELKEKLEDQDFIDYFVTRDKNIRKQVLKFLEKDSRDLAILLELLAKKYNAVRFDVAKDLEMIGERAFLSIINRLAIAKDKNNLSSKTHLLLPFENWKKKSLFSFISKLDKEEKKFFLPYLVEVNFENLYSEAINPEIDEETRLAISYLLGEKDVLEPFIAKFFLSINAIDALGKKAAILTISQKKKYKYSIVMIFKELLKSPNNDVRSSAAEILGQIERKAEEVVPALIPLLQDQNSGVRSSAVSALGLFGKKAEKAVPSIVSLLKDPDEDVRRKTEKSLKNIGTAETITVFIQLLQNQDSVIRSFAVEILGRIGEKAHSAVPALILALKDQDSWVRSSVAEALGKIGEKAHSAVPDLIPLLQDKNSSVRRYVVEALGKIGQKAHSAIPALILALKDNDVRSSAVEALGKIGEKAHSAVPDLIPLLQDKNSSVRQHVVDTLGKIGEKAHAAVPALILALKDQDIWVTEALGKIGEKAVPALILALEDENKYVRAYAAQALGAIREKAQKAVPNLIFLIKNGDENTKEFAAQALGKIGKKAVPALILALEDENKYVRAYAAQALGAIGEKAEKAVPTLISLLQNQDENVRRNVVDALGQIGEKAEQAVPALIALLENENDFIESVVRALGRIGEKAFSSLILLSQKPILQAQDFYITVNAQQELKIIGEKAVPVFILLLQDPDSYVRSSAAKALRIIGEKAEQAVPALISLLQDQDSQVRNSAVQALGAIGKKAEKAVPALIPLLQDENVRMNVVEALGAIGKKAEQAVPALIPLLQDENVRMNVVEALGAIGEKAEQAVPALIPLLQDENVKISVLETLGLVGEKAVPVLIPLLQDENVHMRILAARALGAIGEKAEQAVPALIPLLQDKNRSARATAIRTLGNIGEKAYVVSSFLIPLLKKDKHEKIETIRALGKIGEKSHTVVPSLVNLLQDKNSDVRREASVALNEIGEKALLSLIPLLRENILVRSQAVQILGKIGEKSSTVTPFLIPLLQEKDVGVRGFAAAVLGEIGRDAVFSLILLLQDNNQYVKREAAKALEKMGEKAEKAVPTLISLLQDQDSEVRSSVIKALGSIGEKAEKAIPTLISLLQDQHAEVRSSAARALGNIGEKSIPILTPLLKDSDKYVRKNAIRVLGNIGEKAVPTLIPLLKSLDKYDRRNAAEALGQIGEKAEEVVPILTPLLKDPDKYVRMYTAEALGKIGEKAHTAVPDLILLLQDKNSYVGVREVEALGLIGEKAEQAAPVLISFLQEPNLDLKFSAAEALIQLGKVEEAIPALVSLIKEEDFFGRTYAIKTLGKIGEKAEKAVPTLILLLKNEDWLVKSSAAETLGMIGKKAEKAVPTLILLLQDDNRHVEKSVVEALIRIEKISPLIPLLRNKNYHVRYSAKKILINIGEKVLPFIREFVQTERNKATIESGLAILNRCLWNAYLEEKKIFHQMDIELLSLSKNKNYFDTVATIYAWQGNAKKAYEYAAKAIAETPKRVKLLLEGKAPKQVEENMKKK
>NZ_AP019860|6514664:6589538|6527115_6530952_+|WP_173013516.1|DBSCAN-SWA
MDFKNGVWKHRELKDFRVSLFSPYSENESLNRWEKIRNQEWEKEVQVIEKAVKSYETKSTILLILLHIGNAIIGAFLSIKMFPKKVKVALWGMIASTITFGISNFALTFIILDDARGNRNTHGIRNLERWLFLSIFTFGLSNFTFIFSPKKLEGKILLQLRLLKNKARLYARQNQYTKAEFFYQRSLKAIQNKNLYFETAELMSEIAILYQQMGEYTKAKHFHTKANSTVEHPKVLNKYALWHEEKGEKKEAEELRNKAFQSIKKQINKDPKNEYLHASLAEMYQDNKNYNQSEKTYLQAIELAKTNFSLIEILKNFALFYVGIQLYPRAEDTYIKLIEETQTTLGTHNSIYISLVSDIALLSKEMRKYKESEEFFCENMQVIENVLGKNHLIYIFNHIELANLYSQIGEYGKAEPIYTEILNIVEQMNEKNSFAYASCLNQMGKMYYKIDEYDKAEKYYEKAKQIYHDVLGEYHPEYKACLMNELELYQKQRKSQEVNTLINEIELLNEQQSLCELPENTEVENLQVTISLDVDTLNLIVEQERLKQAQREQQVNEQEIIAAFLQGREENFTNALQMSQNAILLYRKKEYKKALVLQKKASEIIQKTHGKNDRCYVTALNNLAKLYDKTGNYEIASELFSKAVNLRGKILGTEHPDYATSLENLAHLQYRQKKKQSALFNMLKAANVHNKMILRIFSIGDEKRLEKYIDTFEIQYFTLLSIFYQSYKVLHIFSPQVCDLILKRKSLHRELTSIKRDSLFTQQRPDLEESFARLRQIKLQIAQLILASTDASSTQIAKLEAEKEQLERVLAAEVPELELEKKLTHVSHREIAKLLPADSLLVDFVCFREVDVESMRYLDERYIAIVIYNEQISKELAFVDLGAASEIDELISKYKKQLTTGERKIHVVAEDVLPSENTTVKTQDAYGEQLFQKVFAPVLRKTKDCKRLILSPDGGLCLLPFEVLPQPDERFVVEDYEISYIDSGKDLLRFGYQTAPKSQPVVIANPDFSLSGDQSYTDIRNSIPQSIVAELGQTIQRKVQETKAQYYFPPLAATHKEGVTIGKMLPREYTSLMEEKALDSAIKKLQAPQILHFATHGFFMVDEQQKETDLDEMQDLNESPIFRGEKFRNPLLRSGLALAGANTFFENKQPAPDAEDGLLTALDITGMDLFGTDLVVLSACETAVGEVKIGQGVYGLRHSFIIAGARTLIASLWKVPDEETKELMVGFYRKILRGSEKATALRETQLEMIQKLRDTGKSPDPYLWGAFICVGDPGKMNL
>NZ_AP019860|6514664:6589538|6552022_6552532_-|WP_151970389.1|DBSCAN-SWA
MLGELTKYKKPFQIRTLLLLRKTKKILKKVGRKTSLIGLYVRKDISIFDELEKLNQYYFSPKMVKTCSEEKFAQIKEFLILCKKTGKTTKTLQIAEVLSRNIQHDANYEKQIDSNFYFIKSFYNAVLDHRKIYKSQASRNIQKQDFFVTKELSLKEILEIKIRQLQAQK
>NZ_AP019860|6514664:6589538|6561892_6564244_-|WP_151970393.1|DBSCAN-SWA
MNYLKTFFLILVFVSFGFAEDDKNVAINEMNTRISKLEGQLEKVQKQSDILNSQFLPLSKYRFLRVSVFGGDYKLTIDTRGKFAHVNCVQGKILEQDDRSFKIEKTSGWSHVDFIVEVKIFDKVISVYARNDQPREIILRDHLNQILNKNRDNKVRIGGTHRIYSIKTQTAENLLLEEQLENQQSKSNLLQKQIDILNSQFLPLSKYRFLRVSVFGGDYKLIIDSRGKFAHVNCVQGKILEQDDGRFKIQKTNGWTHVDFIVEVKIFDKVISVYAINDQPREIILRDHLNQILNKNRDNKARIAIQRIYSIKTQTDSLDVDGTTKSNGDSEIGGNLTVSDTYLPKDVLELSAKNIEMNNKGISTKGRDVYFHSDSADFAHGIGMYHDTKKFANVNVNGPVVYGYYGGALGSTEGGQKIALRWDSNGDVKVTGQLSAKKISGAEDLSIGKVNANIISLNGGGTIKRVFDNGNYSLEISSTNLYINNKGISTKGRDVYFHSSITDFNHGIGLYHAAYSDGNKNYPAKLFAGENVNGPVVYGYYGGALGSNTNKIQKIALHWDSAQNVSVKGNLTTNKTLNANHISTKSVNVTEKFDAKSLHIDKDGWIGMNTAPVKDFTLAVNGRIGIGVTKLADAATKLAVKGKITAEEVRIVKMDNWADFVFADDYKLIPIDQLEQSIKRNKHLPNIPSEREVKEQGIQLGEMQAKLLQKIEELTLYTIQQEKKITTLQQQKNTLENKVAKMKQNEQKINALQKQLVNMQQNEQKINALQKQLDLVLKIMRNK
>NZ_AP019860|6514664:6589538|6546592_6548125_-|WP_151970385.1|protease|DBSCAN-SWA
MKSELSGASPSHLTNICGDCGFNKILPEDEECMSCGAPIYKPTQHKKQVSFDTVLIELVSERKTYNIGIPPERLFGPFRRYPFWGFFGKAKIEIVDEGIVVIGKKMRGGFVFFFITMLFIVAIFLLLLVKTMGIFIVFFLALSGIKGMEEIRKVNSEITIPFTSIIAVTSPNKKRYLGIAVSIKDKRVIQKFTFQTISDARDFCSTLTEKASLHTNTKDFYLSTEHNPARVTYGVVALCILSFLPFTLDYFSILHKLPDYFCIPHEFLTWPYMFFGEERISNFALLLSGKVWILVTTIFVHLNWISFLCHTSIFLVLAKKVERLHGSLYLMKLILIFGLSANVVQVLFFDNSPRELVAINYGLFAYIWMYGKYTFHPSFCISKPLMIFFIFFLFASEFMAIFSLENGIREFPWAVQTTFTIYMLIGLYWGIFIGFFLGILYVSWEQSRYYFNKILIIALLYTFFTVIAIQLNLEVLWLINYFVQIAFFILLYRFQPSLSHLNRNLENAPR
>NZ_AP019860|6514664:6589538|6558260_6558464_+|WP_151970391.1|transposase|DBSCAN-SWA
MSTYTQIYYHIVFSTKNRQPSLTKECRPKLFKYIWGIVNNKKCRLIRINGVEDHLHILTKFPEVPIL
>NZ_AP019860|6514664:6589538|6572119_6572209_+|WP_151970396.1|DBSCAN-SWA
MTKSLRKMGFGANRKKVLRLRNELKIRAI
>NZ_AP019860|6514664:6589538|6532279_6533758_+|WP_151970375.1|DBSCAN-SWA
MSIWNSMKFKRSLIKQIKPEKNQKPSLGEIVNTLRCLWIQKAKGDKVVKEIEKIRCHYPSEEKLASVAMGAYMSVFQNQQLLNYALSLKNTEEFFFEGYLFQMRYLLKKGHGMVAVFPVMRSIQSNSSQQLLNGCLIWFFDRYFNTLQSKVNDKENPLSKERSAIAMFLLGTFARSANKKIIPNFIDAAASLGKSCSHYIKQKEKQFQKLFEDSLYFSKVYGIEAWGGPGFIKRCYDLTHIGSKNTMQEMSKLIAWKRAKGEESAKLSRDEKEIANYEYNAQLRNLKTLQNHFQKMEQSYGEFVPLLEFKAEQLAHSDAEGAITILKKIITRHPNRSYYAYRAAQILEQHNRLSEARPYWIHAARTLGDDWRNHLASIYATTKMYTFEAELLQKAPPTLLSPAAKVVAQHLEQRLLNANECYYITAAYALAEKAAQVFHLAALHASDVQEREELINQAYKYYEMVDNPEGMHMKYPEQVFEPIEIPFTIIPV
>NZ_AP019860|6514664:6589538|6540933_6543444_+|WP_151970382.1|DBSCAN-SWA
MNKCLLLLLLMGSLAFADVLKLGGESTNYYPVYFESTDAPNTLRLGSYKNFGGGKVESLDAKFQWRANRYGWVKFEEARIHQEIGVFIAGYSADINKSQYHGIVLWLRGNTQYDHTSAKVMNTSKEYKDSKGNQIREVAGGNLTLSTKTFSIKKQTQVDPYVGKAGNLYPKNVVVGGDTFVKGRVGIGTYAPSVNLHVEGKTFIRASSTGLLEMESLSGETDIQFRDPKNNQSWQVGSNSTGFFIHDDKASKYRFNINRNGNIGVNIKNPTAKLDVVGSFRVGSNSEHVFQVTDDDAKNQMLLSTSQRTQNKTPRNIHFRSFGNNAKANVLFMNMSSGRVGIGTDNPSVNLHVEGKTFIRASSTGLLEMESLSGETDIQFRDPKNNQSWQVGSNSTGFFIHDDKVAKYRFNINKSGYVGIHTTKPTTHLDIVGNLRVGSDNEHVFQVSDDSAKNQLVLSTSQRTQNKTPRNIQFRSFGNNAKANVLFMNMSSGRVGIGTTNPSATLDVNGNIITSGYVHTQGKDVYFHSKITDMNHGIGMYYDTKKFANINVNGPVVYGWWGGALGSTEGGKKIALRWDQNQNVSMNKNLSVAGNANIMGNLDVSGTVKAKTLQIDNEGWVGLNMTPEKGYTLSINGSAQIRGKVVTRGHVHTQGHDVYFHSNSADFAHGIGMYHDTKKFANVNVNGPVVYGYYGGALGSTEGGQKIALRWDKNGNVGIGVINTQGSKLAVKGKITAQEVRIINMKDWADFVFADDYELLPMDELEQSIKKHKHLPGIPSQQEVKEKGIQLGEMQAKLLQKIEELTLYTIEQNKRLQAQQKQIQELKKLIQLQQIK
>NZ_AP019860|6514664:6589538|6559012_6559252_+|WP_173013518.1|transposase|DBSCAN-SWA
MLRNVKAFSSKWIKQNKIFPCFTNWQDGYAAFTLSFDNVNSVIEYIINQEQHHYRKSFLDEYKTLLIQAGIQFDPKYLL
>NZ_AP019860|6514664:6589538|6539207_6540869_+|WP_151970381.1|DBSCAN-SWA
MFKICIALLFLMSISYAQDICTTLDSGEGFTEQSFEEKEGLSLVGVKKLLWPAKERVLHVRFVGIDDDNIKQQIQEIVEDNWEKCCGIDFRFDNHPKAQITVNIMAGTKNNSFVGTDSKKKVPSMNLSFYKLDSDGNAYLPKDFFEIVDGKKKIRKGSYEYGTILHEFGHAMGFMHEQMSPHFDVKWDKDKVFSYYRKNGPREWTDKEVRDYVYRNVLNKQEYTRIARRVVTYETEWIFGFIPRRTKKIDMRSIFVPRYTASEFDQHSIMCYPLMLELAQESKELRLGTLNIKYKKYLKAKDYKSLHKVLSKQKNIDVDTKATITGRNGPWHLYTTLPTNSKLKSSAKVPKKAYRIVEANGVLEIYPAIGGGRTLSVMDRYFSNKLYPFPTKSQTHNFAVREVNRAFDEILLRQPTADERSHYVDYMKKNNLLKLRDQVANLAEGKIKKLYFSLAGREPSQEEMNSDKRLLAMKDFTSLEASASLEVNLRSREQFGNVAQLEVIGLYSVHAGGSFYVDNHETVEFRAGEEILLQEGFTAKAGSDFTAKLYSNE
>NZ_AP019860|6514664:6589538|6533776_6534838_+|WP_151970376.1|DBSCAN-SWA
MDKLQKSSANYYDILGISVAADIEQIRKRYRILALENHPDKFRMSTEKQKASERFKAIRMAYDVLSNIEKRNQYDICLRTGKEFTNVHNSNDPLEPSLGEILSDIDRYQFPQQARNMSEGLKEFVDKSIIRSESFQEKIIDVLSIKYSEVETSPVASITGEVAEEKFILTNLRFIVARQGRTSFTQGKTMYSQSSYGGYGKLLLDIEKIVLLWDVRRNSKTFDIAFYGTDLPLSGIYFTIAGSFFSFLWIAELYDIEFELQTRFMQNPDVGRKISQGLALLGSSMILLPFVLLPFILPMILKARLYKYVSSFWWEVASLFMIPLVIHMFYSRKYKQQADISEFIHKWLPTPPK
>NZ_AP019860|6514664:6589538|6522973_6524257_+|WP_151970369.1|protease|DBSCAN-SWA
MYKDEYMQKKPIYVTLSLIAISSVTFLYKIELENIFSGQRFFTLNFSYLSWWHFTINMLLLYIFGKKIESVFGGRFFLWQVLVIAVISQTMDYLLPIHIKTQSTQEVGAGMSGILCGLFAYAWLCGKFSSRIGVSRLWVIAFFLVTLASLPLLLQGTPITGYSHVAAIFAFAVGMLWAFSQQRTYLCWYVFAYVLLWAFICLALLLAIVIFFPQLFYKMNLSKGVVKVLFLMEIVGFVLLCRLPSWRNALPMRPLGHVHNLRPVKHPSAITPTKLQNDYSTFCVFIPPKRLFGPVNRYPFWGFFGKTTFTLMDEGIIIAGNKIRGGFILTLLSFAFIVSMFLLLALTKIGYFWIFIIAVLISKMIELLRKTQSEITVPYPSIIAMNLKSGKQLKVTVQIRNKKVKQSLFFEKEEALCLFEKIRELLK
>NZ_AP019860|6514664:6589538|6549122_6551339_-|WP_151970387.1|DBSCAN-SWA
MRKIVVLLFCLYSFIFAAELTLGGSAKKYYPVFFYDDAWARGAFDVHIYRQVHDGTTWHGTLIAKFRSHGDRLNGSSTSFAEADIHYYIPNKTTNANLASNFIAGYTYAKHHKGLIVWLRGGTKYSFSFAAGRGKSRAIYNSGSNMEKPLIIKTSPKEQYYPLDKVKEYVNKGRTIDQINSKVINIGNTAAIRINGDNQGGDFLDISAPNFRLNNTGIWTKGNVGIGTTNPSAGLHLQGTALIRASSTSLLEIESLSGETDIKFRDPKNNQSWQVGSNKNGFYIYDDKAAKYRFNLNKNGNIGINTKNPEGTLHLGGSVPRLVFGEESKYAIDINGGRFRLKSLDKHTFIEMSGASTTPKVQINSELLILKNVSINGRLQTTAGVHTGGKDIYFDYNHTNNGHGIGLYRAAYNHGNENYPAKLFAGENIDGPVAYGWSGGALGSKDGGEKIALRWDQNQNVSIKGNLTVEKTLHANHVSAKSLNITENFDAKSLHIDKEGWVGLNMAPEKGYTLSINGNAQIKGKIITRSHVHTQGNDVYFHNDSNDLAHGIGMYHDTRKFANTNVNGPVVYGWSGGALGSTDGGQKIALRWDKDGNVGIGVMNTQGSKLAVKGKITAEEIRVINMKKWADFVFADDYKLLPINELEQSIKRNKHLPNIPSEREVKEQGIQLGEMQAKLLQKIEELTLYTIQQEKKITTLQQQKNTLESKVAKMQQNEQKIDVLQQKLDSLLRMINQK
>NZ_AP019860|6514664:6589538|6564613_6571462_-|WP_173013520.1|DBSCAN-SWA
MGWKYLQYVVIFFILFCLAFAQSEDEKLNKQLELLVAQLQSSNIDHSLSALVELRKLGDKAKVIRPELLKILKKVNINNRSIIQCVVDIITQSSPQQVKSKKTPKTITTRSAASRISKNLGGLNILGTSSDFHQRLRYNKQYAVVIGINKYDNFTNLKGPNFDASEIARVLRDRYQFDHVNLLLDKPSPRQANFNGRATKVTKNIVEDAVQSLKKKVKPDDALFFFYAGHGVPGYLVVGDSEKKHSGRPIEKSMVSLKAIAKSLESCGARHTLMVLDCCFSGSLLEKEYRPDFSNLTDKAFVSPGGSNLTRVFNRRVFQVITAGAGDEAVADKLDEISTIYAKQFKDSRGHSPFTAVFLQAIQGLTGRDDGIILASQLGFYMMDTLVNDDRINASQAPRYGTLGGNGDFMFFPVDKVLNPKMVAPLYLNGVEFAAFRRSGCEALENFIAEKSEKDRISLIKSALPHVVKLITDEQKIPRMAAVKFIKNEAQKYASKIEVFSIVVPILAKTLTPKKRKVVFSLSNDDQYMMIECLGSLHSHIKDEGPIDILKRYYKQQESQWRDHTKDKEIPYLVKERMKELPVDVDINSKTPQVQGHYYHQRIQIYRWLHSTGKEKIELYESSKNKFLSLTENVSTRLQSFDLLKKELTNRDFIEYFATRDKTIRTTVLAFLAGQDRDLPILFQLLKEGGEDIKIDAAKDLEKIGKRAFFVIVDRLKLAKAKKLLSQKKYLWLPLINWQKESLFPLINHLTYQDKQFLIPLFAEVAFDKLYSLMLNGSKNKQIRSQAAFFIGKRKTIEPFIAKFFISLKKKNVFEKLTAIDSIISPEKKCSMLEVVVELLKSSDEIVRLSSVKILKEMGEKAHSAIPALIPLLQDSDSKVREHTSLALAKMGEKAIPFLIVLLKNAQQNARLSAFTALQEMGERAHPAVPALIPLLQDSDPKIRVNVSLILAKIGKNAHLAIPALISLLQDSNSKVRGNASLALVKIGKKAIPFLIEALKNLDGDSVATVLQETGEIAIPALIPLLQDSDPHVKKRAISVMSEMGEKAHEAVPTLIPLLQDADPKIRESVSRTLANIGKRAHAAIPALIPLLQDSDRYVKKEAIRALWRMGEKAHVAIPALIPLLQPGAFTADAAYVLGEIGEKASPAIPYLIPLLNYRANQLAVVKALGKIGGKAEKAIPYLIPLLKKNGRRNRTVEAALKNICKNPFLIPVSQDPSTKVMKYTFVGRSRKRIDTEDILILLSLLHNQDNEIRLSAAKFLIETRATELREKMGKESHMAVPALIPLLQDPQMKYPAIQILGKIRGKAAIVHLIPLLQSKDIYVRGCVVQALGEMGEIAQKTVPLIIPFLQDDDPRMRQTAATTLGKIGEKAHSAIPALISLLEDSNSKVKKAAIIALGNIGERAHSAVPFLKNLLQDRDYKVQGDVVEALGNIGERALSCIPSLMKLSNSHLLRWKAKQSLDKIRQKTQKFVPSLTFLLQNSNPEVRRYAISVINDIGEKAVPSLISILQEKNYNGRLSAVEALGKISKKADQVIPLLMPFLQDSAPIMRMTAAAALGEIGEKVHETIPSLISLLKDSDLEVKSAAVEALGKIGAKAEEAIPFLAVLLQDESSDLRRLATEALGKIGEKSERIVFCLIPLLEDENSKVRDVAIEALVNIGLTTQKSIFSLIPFLHDRDAQVKITAAVALSMAKEKVKNVVPHIIPLLEDQSLQVKVETANILGDFGQKSYLAIPQLILLLGSGVTGVEVQAISALGKIGEKSHLAIPYLMEFLEDGLNPEIRRVSAKALGRIGKKSQKAIPVLISRLKKEARGDGELYAYKEILEALVQLEEKSIPYLIPLLKDPSSSTRIRAAEALGKIGEKAEKAIPDLIPLLKDQNKYVRIYATEALGGIGKKVEKAIPDLIPLLKDEVPMVTINAMEALGKIGGKAEKAIPYIIPLLKDNVYENAPETLGKIGERAIPHLIPLLKDPSSNTRSRAAQALGKIGEKAEKAIPHLIPLLKDTSSSILSRALGKIDRPRSRAAQALGQIGEKAEKAIPHLIPLLKDKYSEVRESTAEALGQIGEKAIPHLIPLLENQHPEIRKGVTKALSKIGKKALHAIRKSNHVILNSYLWESYLHGYKNAFTQRDIELLSQSKDKTHLETVAITHAWKGNEKEALKYAKNCSKNAKIRINLLLKGISQNQVELVIKNNFKFLNDRLWENYVKEQSGGITKQDIIILEEAYETHQLDTLAAIYAWKGNIQKANKYADKAQGEAFKRVKLLLKGKPPKQVEEEMKKGQN
>NZ_AP019860|6514664:6589538|6525813_6526509_+|WP_151970372.1|DBSCAN-SWA
MVTTRAVLAYHDGQKQHKIFLIAKTRVGFGKAKKSQNPDVDITMRVLPLRSQELDPGNWARTKKISQHHGNFILRNNQFYIERLGKNGIFTLEGNEIEKESLFTLKDTTQIRLAQESLQLKLKTVRDLETQSVNCLCVERVDNHVHHCYVQVIREVTIGVKKADVNLPGMNGLFRIVTEQEGWNVIPDESGYTKINSEVIQEPTLLCNRDVLSNGLQEIVFCMTEDNDFVE
>NZ_AP019860|6514664:6589538|6522402_6522897_+|WP_151970368.1|DBSCAN-SWA
MRKNVAQALARMGKKNVTMDEITVIDVLSIIESLKGKVKRTDKDFVKVSDKLIPALVEFANASNWYWQSQTNKILERLTNRILWDAYENNDVKKISQKYLKILEKSNDKSYLDTVAAIYAWQKNEEKAYHYSSIALDETPKRIRLLLRGKTPQQVEKEIKNENK
>NZ_AP019860|6514664:6589538|6537766_6538156_+|WP_151970379.1|DBSCAN-SWA
MEKINGKRVKWLQQIDNTAKPMPVDNGSIWHKELYGLLFFDDHISLVDCEGKQGVIPFIDIMLAKITEDVENRYLITLELREEQQNMPKFILQSQLFFLLFYSTMQQHKVPFHFDFTPARLQALGADNS
>NZ_AP019860|6514664:6589538|6577719_6579855_+|WP_151970400.1|DBSCAN-SWA
MRNLIALTLVMFFSTSLFANNWFEENINIFNRKNKLRKLGRNLDKFVAQRAIERAKFLGREVDKKLFQPILKTLEYTVPGHGYLKYLSDQAKDKRKYLPQEFIRIVQKHYRSIDLQKVTYAEDINTVHGDAITIGSEIYFPTRVDLTDGDDVFWMLHELEHVVQYKKIGVSTFLAKYVTQSISEALNQIVKGSFSVHDNMQIEIDADNKAKRIFADVMHKIEVVVPTVKKESINTFKIKNVKTGGYLFTRAILAARFYGGAGDIWQISYAEEQGKEYATMQNVRTKRYLYVERKDDGNHVISATQNISPKDIRCQFFIEKAQKDRDDGQYYIKSRKTKSYVYMNPDQIGYISRRIMLGDIPQKKEVAIWYIKEKEAHTYKLRNGLKKNIGHSGWTISINNMKISDKLEVVCGTDYADPRDTLWRFQKLSGTLCYKIQNVKSGGYLVKEPSCGKVKISVAPHIDKTREKNDYYYSYIWYVDPSPNGLQIVSVRSGQNFMDLNARIRKTNVNYHAYSALACESITSKKDFATAQKDIKFMNDQYEGGARIPTYHLHNKDKVVIEKSLNGTGGKPVVVDIKNRWYFWETQGVSMQKVGKSQKYIVYAKNATSFPIDVALAYKNKKGAWVRHGWWPLRPGEEKYLVTTRHRDLYVHAAGRGRIWGKTRPLSISYNNFKFVGKKKRGDHSAKFTKVLMDRPYYTYVFKHKTAKVKK
>NZ_AP019860|6514664:6589538|6535305_6537765_+|WP_151970378.1|DBSCAN-SWA
MAQAIGIDLGTTNSVVSFLRGGKPEIIPNRFGKNITPSAVFLPDSDSVIVGEPAKSRAEQYADKTFISVKRRMGTNYRRTVNDKEYAPEEISAMILRTLKKDAEEFLGEEVTQAVVTVPANFNSTERQATKIAGEIAGLEVLRVVNEPTAAALAYGHLNQLSQIVLVFDLGGGTFDISVVFAEGNMYDVLFSLGDNRLGGDDFNMHFLGYLVDHLKKEHGLDVSGDKNLLRKVRQEAVKAKHNLTKRETARIYIPEIGTSGGKRVDLDLTINREKFKEIVQPLLERIKQYAHKVVEELKQPKYTQRYADFLGEKLEKCDVILVGGESRVIAVQETLAQEFHGRMFSNINPDEVVAMGAAVQAGILTHHSDVRDIVLVDSTSLSLGTEVVGGGFSVIVPANTPLPVTRTQDYYTVHDNQTSVNVGVYQGESSIAKQNKLLGEFGLNGVPPRPSGQVPILLTYDLDANDILHVEARDKETGRRAEITIKGSQTIPQQEVERMKQEAAQMEQQNVETLRVNRLREKAESLIQESKAIQNMLSSVVHPDYLEKLDNAIKAIQAALRKSDVEEIDRCFYDLYHLIPDENAQEPSISMNVDSCGGFRANEWGRLEIRLLNQGQGAALQVQVTISGATKEKQTGAVAAVYPGSSQIIPLSICPVNPGNAVPISIMVEYQDEAGIPFLVKQEASLEVAYADQPISNATKTVISIGEIINHTGVGNVQSRQQVSGDNVVGSKVGDIVATRSNVSIGNETTPSMATEDTKMSSPKQQETICGKCQAFVPSGFAFCGKCGSKLALTCSNCGSEIPDGFQFCGKCGTKVGS
>NZ_AP019860|6514664:6589538|6531723_6532254_+|WP_151970374.1|DBSCAN-SWA
MRWSRIFALGIVFIFIALADLQIFVFFTALIAFSFLFSFLQTQLGIYYKQKMKSVKRSRAKKGNHKERIVKYLGFIFAYVGAAIVLDYLASLTLFAVALFYFLFFVFVENVLVATSFSKVSTSTISNIVPRKKEQFVLNDKLLTEEILENYQDELLDHQTSESQVTIKNLYDALDD
>NZ_AP019860|6514664:6589538|6572487_6574026_+|WP_151970397.1|DBSCAN-SWA
MDDVKFKTLWEKLLNNSEDIRYTYKPSETFSDKNTIVPQDATDTFSSKDTISPENSKETFSDNKTITSSENPEKEKAYTKTKIEVPLDTKQDYTDLKEINRGGMGIIYQARQKKLKRDIAIKKMLSDKGKEKFLAESLVNAYLEHPNIVPVHEIDTNDEGEILLAMKFVQGISWKDLLYPKTKEQQDRSAEYNLEGHLGILLNVCNAIAYSHHKNIIHCDLKPENVMIGEFGEVLVMDWGIAVDLGSREDEVKETRTFKNTEINHPMGTPCYISPELAEGRGKDISYATDVYLLGGILYEIIYKRPPHQGNTIWKVLLSAREGNMPPFDESVPYELRSVCKRALQGNMGQRYQKVQEFQKAIQDYLAHRQSIIISDKAKKILTEGENLFEIQEKLKEINFSVLYNKLLQAIAGFDQSLELWQENVEAQQGRDQARIEFAKVAFLNNDFGLAKAQLEETTSSIEVTELFNRIEFARLQHENISKKWKFYFRLAIIIIIAFLLVIIRLSTTYKF

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_151970364.1|6514664_6516080_-|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_151970365.1|6516516_6517044_+	FHA domain-containing protein	NA	NA	NA	NA
WP_151970366.1|6517059_6518046_+	hypothetical protein	NA	NA	NA	NA
WP_151970367.1|6518085_6522318_+	CHAT domain-containing protein	NA	NA	NA	NA
WP_151970368.1|6522402_6522897_+	hypothetical protein	NA	NA	NA	NA
WP_151970369.1|6522973_6524257_+|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_151970370.1|6524313_6525126_+	hypothetical protein	NA	NA	NA	NA
WP_151970371.1|6525351_6525585_+	hypothetical protein	NA	NA	NA	NA
WP_151970372.1|6525813_6526509_+	hypothetical protein	NA	NA	NA	NA
WP_173013516.1|6527115_6530952_+	CHAT domain-containing protein	NA	NA	NA	NA
WP_151970374.1|6531723_6532254_+	hypothetical protein	NA	NA	NA	NA
WP_151970375.1|6532279_6533758_+	hypothetical protein	NA	NA	NA	NA
WP_151970376.1|6533776_6534838_+	DnaJ domain-containing protein	A0A1V0SIM1	Klosneuvirus	5.5e-07	36.6
WP_151970377.1|6534935_6535304_+	hypothetical protein	NA	NA	NA	NA
WP_151970378.1|6535305_6537765_+	Hsp70 family protein	G8DDB7	Micromonas_pusilla_virus	1.4e-90	35.9
WP_151970379.1|6537766_6538156_+	hypothetical protein	NA	NA	NA	NA
WP_151970380.1|6538456_6538807_+	hypothetical protein	NA	NA	NA	NA
WP_151970381.1|6539207_6540869_+	hypothetical protein	NA	NA	NA	NA
WP_151970382.1|6540933_6543444_+	hypothetical protein	NA	NA	NA	NA
WP_151970383.1|6543606_6545274_+	hypothetical protein	NA	NA	NA	NA
WP_151970384.1|6545455_6546538_+	hypothetical protein	NA	NA	NA	NA
WP_151970385.1|6546592_6548125_-|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
WP_151970386.1|6548302_6548833_-	hypothetical protein	NA	NA	NA	NA
WP_151970387.1|6549122_6551339_-	hypothetical protein	NA	NA	NA	NA
WP_151970388.1|6551380_6551566_-	hypothetical protein	NA	NA	NA	NA
WP_151970389.1|6552022_6552532_-	hypothetical protein	NA	NA	NA	NA
WP_173013517.1|6552879_6558009_+	caspase family protein	NA	NA	NA	NA
WP_151970391.1|6558260_6558464_+|transposase	transposase	NA	NA	NA	NA
WP_173013518.1|6559012_6559252_+|transposase	transposase	NA	NA	NA	NA
WP_173013519.1|6559814_6561464_+	hypothetical protein	NA	NA	NA	NA
WP_151970393.1|6561892_6564244_-	hypothetical protein	NA	NA	NA	NA
WP_173013520.1|6564613_6571462_-	HEAT repeat domain-containing protein	NA	NA	NA	NA
WP_151970395.1|6571578_6571785_-	hypothetical protein	NA	NA	NA	NA
WP_151970396.1|6572119_6572209_+	hypothetical protein	NA	NA	NA	NA
WP_151970397.1|6572487_6574026_+	protein kinase	A0A1D6Y713	Golden_Marseillevirus	9.5e-16	25.4
WP_151970398.1|6574092_6575286_+	hypothetical protein	NA	NA	NA	NA
WP_151970399.1|6575893_6577459_-	DUF4041 domain-containing protein	A0A142LP25	Marinitoga_camini_virus	3.7e-76	59.1
WP_151970400.1|6577719_6579855_+	DUF1036 domain-containing protein	NA	NA	NA	NA
WP_151970401.1|6579990_6581994_+	HEAT repeat domain-containing protein	NA	NA	NA	NA
WP_151970402.1|6582380_6588812_+	HEAT repeat domain-containing protein	NA	NA	NA	NA
WP_151970403.1|6589154_6589538_+|transposase	transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_5

Nucleotide sequences of DBSCAN-SWA_5

>NZ_AP019860|8936311:8992220|DBSCAN-SWA
CCTACTCTGTAGCAGCGGTAATGTAATCCCGCGCCAGATCTTGAGCTTCGTTGATCTGATTTATTTTGATTGCTTGTCCTTGGGCAAAATCTTTTCTTTTCGCATTTCCACCTCCACCCAACAAATCGCAAACTTTTTTCAGTAATTCACCTGCATGAAGTTTGGGATGGTCCGCTAAGTGATCCGACACAAAAACTACGAGTGGTAGCTTTCCATTCTTTTCGCAAGAAATAACGCCAGCACATGGGGTAGAACTCTTACGCATCAAATCCGCCATATCTCTTAAGTTTTCCACTTTAGCTTCCGGTAAGGTAGCAAAAACAAATTTAACACCATTGATATCACTTGCCTGCTGCAAAAGAGCATCTCTTTGGATTTTCACCTGTTGTTGTTCAAATTGCTTCTGTGTCTTACGTAGCTCTTTTATTTCGTCTTGCATTTGCGAAATTTTCTCTAAGACTTGCTCTTCTCCTACCTTTAACTGCGTCTGAACTTTGTCGAGGAGTATATTTTTTTCCTGAATATTTTCAATAGCGATTCCGCGCGTAACAGCTTCAATTCTACGTACACCAGCTTGTACAGCGCCTTCCGAGGTTATTTTAAAACAACCGATATTTCCCGTATAGTGAACATGTGTTCCTCCACATAGTTCCATCGAGTAGTTGCTTATAGATACCACGCGAACTTTCTCTCCATATTTTTCGCCAAAGAGAGCCATCGCCCCTTTGCTTTTTGCTTCATCAAGAGAACAAATACGACGGCTAACGCGTGTGTTTTGCGCAATGGCTTCATTTACAATACGCTCTATTGACAGTACTTGTTCCTGGGTAATTTTTTGTGGATGCGATACGTCAAAACGCAATCTTTCAGGAGAAACTTCCGAGCCTCTCTGTACAGCGTGTTCTCCTAATACACGATGCAAAGCAGAATGCAACAAATGTGTTGCCGTGTGATTTGCCATAATTTTTCGACGTCGTTGTTTATCTACATGTGTACTCACCCAACGAGGTAACTGCGATAAATTTCCTTCGACAAGTTGTCCATAGTGCACATAAATCTCACCATGCTTTTGTGTATCATCTACTTGAAACGCAAAATTCTTTCCGGTAATAGTACCCGTATCGGAAACTTGCCCCCCCGATTCTGCGTAAAACGTGGTGCGATCTAAAATAATCTTATCCGTACCGATTAACTTCAAAAGCTTTGCCTGTCCAGAAAGTTTTCCATAGCCATTAAACTTGGTCGCTGGAAGTCCTTCGATTTCCGTCATGGAAAAATTATAATCAAATTCTTTGTCCTTAGACAGTTCGCGATGTTTTTCTTCTGCTTTTTTCCATTCTTTATGATTGATAGTCACTTCGTTTTGTTCCGCCATCAACTCAATAAGATCCACGGGAAATCCGTGAGTCTCATATAAAGAATATGCTTTTGTTCCTGAAATTTCTTTGAGATTCTTGCTTTTGGTTTCCTCTAACAATTTGTTGAACAGAGATGTTCCATTTTCCAGAACCTTAGAGAAAGATTCCTCTTCGCTTTTGATCACCAGCATAATGTGGTCTTGTTGTTGTAAAATTTCGGGAAAAATATCAGCGTATATTTTACCTACACACGGAACAAGTTTATGCAGAAAAGCATCACTAGTGTTTAGATATTCTTTCGCAAAGAGAGCTGCGCGTCTTAGAATACGCCGTAACACAAAACCACTACCTTTGTTTCCCGGTAGACCTCCATCAGCAAAAGCAATCGTGATAGCGCGTATATGGTCAGCGATTACGCGAAAGGCCACATCAGACAACAAAGTATCTTGCGCAGAATACTTCATACTACACAAATTTTCCGTCTCTTGTATAATCGGAGCAAGTAGATCTGTGTCATAGTTAGATTTTTTATCTTGTAGATAAGCGACGAGACGCTCAAATCCCATACCTGTATCAACATGTTTTGCAGGTAAAGACTCTAATCCGCCGTCTTCATTGCGATTGTATTCAATAAATACCAGGTTCCAAATTTCAATAAAACGATCATTTTCACCATTGACGCCTAGTTTCGGATCTGTTGCCAACGCTAAGTCACCAATCGTCTCACCACGATCAATATGTATTTCAGAACATGGTCCACAAGGTCCACTTTTCCCCATTTCCCAAAAATTATCTCCTTTACCAAAAGGAAGTATTCTTTCTTTGGGAACACCTGCGACCTCATGCCACAAGGTGGAAGCCTCTTCATCAGCAGGAACACCGTCTTGCTCGTCACCACCGAAAACGGTTACCCATAGACGCTCTTGAGGAATTTCCAATACCTTTGTTAAAAATTCCCATGCCCAAGAAATCGCATCTTTTTTGAAGTAATCGCCAAAGGACCAGTTGCCAAGCATTTCAAAAAAAGTATGGTGGTATGTATCTCTTCCTACCACATCGAGATCATTGTGTTTTCCTGAAACGCGTAAACATTTTTGCGTATTAGCAACTCTCTTGTCGCTTGTCTGACGTGTACCTAGAAATATATCCTTAAATTGATTCATACCAGCATTACAGAAGAACAAAGTTGGATCTCCGTGATTCACGATTGGTGCTGAATCTACGATTTTGTGATCTTTACTTGCAAAAAAATCTAAAAATTGATTGCGTATTTCCATTGAGGTTTTCATCGGATTACCTTACTTGATGCTACATGAAATAAAAATTTATCTAGAATCATAACCCCTTTTATAGTATCATATTATTAATATTTAAATTGTTGCTCTAAGTTATGATTACTTTGTCTAACATATGGTTTTTTATGAAAAAATGTATAGTTTTTATCCTACTAATAAGTATCCTGTTATGTCCAGGCTGCTCCTTATTAGAACTTCCAGGCATGATATTACAGCAAGTGGTACCTATGGTGATTCAGTATGCACCTTATGCTCTGATGTTTATAGAAGAAACAAACGAACGAACCATTGCTCAAAACGACCTGGAAAAGTTTTATCGCGATTTGCATAATAATATACAGAAATCTGATGATAATTTAAATGAATTATCGTTTAATTTACGTGAAAGTTTAGCACGAAAAAATATAAAAATACAATCTATTTATGTTGTAAACATTAAAGACGTAAGTGAAAAACAGCTTACACATTTTTTCACAAAGCTCTCAACCCAAGGAAAAATACATTATCAATTTGTAAAAGCAAACACGGCAGAATACAAAAACAAAATAGCCGAATTGCGTTTACAAAACAATGTCACTGTGCACACGACACAAATAGCGGCAACAAATTTGATAAAAGAATACTAGATTCACACCCTAGTACTAAATAAGGGTGTGTTCAAAACGGGTTAATTTGTGAAAAAAATAGTTCTAGATATAAAAAACATTCTCTAATCGAGAACTCATTTTAAACACGCCTAAAAAAATACTCCAAAATAAATATTTTGGAGTATTTTTTATGAAATCCTGCAATTATTCTATTAAAACTCTAGTTTTCCATTCATAATCGTTATATATTATGTCTTTCTATTCGATATCATTTTACAAGTTTTATGTTGAAATAGCATTGGTAGATGAAAGGTCATGTCTTGAAGTTACAAATTTTATCAGGACCAGGAAAAGGTCGAATATTCCATATCCAAAAAGAAAGGGTAACCATTGGTCGCAAAGCAGACCAAGATATTCGCCTAGTCGACGATGTAAAAATATCTCGTTGTCATTGTGAAATTGTTCATGATGGTGCAGATTACATATTACATGATTTGAACAGCGTAAATGGAACATGGGTAAACGACGAAAGAGTAACGTATGCCCAACTAGAAAGCGGTGAAACTTTTACCGCTGGCCAAACAGAATTTCTGATTCTCAACGAACAAGAAAGCGCTGTTACACTCTCCTCATCACCTACCGCGCATTTAAATTTTTCGACAATATCTACCGCTAGGTTGAGTATTGAAAATAGTGATATTACGGTACTCAAAAAGCATATTGCCGTATTCCAGAAAGTTTCCGAGTCTCTTGTCGGCAAATTACAAATGGAAAACTTTCTCGAAGCAATTGTGGAAATCATTATAAAGGCGATCCACGCCGAGCGAGCATTTGTATTACTCGTCGACCAAAACATGCAATTTTCTGAACCTGTCGTAGTAAAAAACTATGCCACAAGTGCGACAGTTAGCGAAACAATATTGCGCAAGTGTATTGAAGATCGTCTAGCAATTCTCATCGAAGACACCCAAAGTGATAGCGATTACAAAAATAGCGAAAGTATTCGCCGTTCTTCGACACGAGCAGCAATGTGCGTGCCTCTCATTTCCAAAGATAAGGTCGCGGCAGTCATATATCTCGATTCAAGACACGAACAAATATTTCACCAAAATGACTTAAAACTACTCGCATCTATTGCCAAGCAAGCCGAGTTGGCGATTGAAAATATAAAACTATATGAAGAGCTGCAAAAAAAACACCAAGAACTGAAAAGTGCTCAAGAACAACTTGTAAAGAACGAAAAATTGTCTATCGTCGGTACTCTGGCAACGGCAATCTCTCACGATATGAAAAATATCCTAACCCCTATACTTGGTGTGTCGTACATCGTATTAAAAAATGATCAAGTAGATCCTTCACTACGCGAGGCTTTTGAAAGACAAATAGAACGTCTACAGTCTCTAACACAACAATTGTTATCACTAGTACGAACAGATCCGATAAAACTAGCGATGGGAAACATTAACGACAAAGTAGAACAGAGTTTACAACTCATCAAAACCGAAGCCCGCTGCCAAAAAGTAACGATAAAACGAAATTTTACAGCGGATCTTCCCAGTGTTTATATGGACGTAAACCGTTTAGATCAAGTATTTATCAACCTGTGTTTAAACGCAATTCAAGCAATGGCGGAACAAGAAAAGTCTGTACTCGAAGTGGGCTCTCACCAGGACGACACACATGTTATTTTATACTTCAAAGATAATGGACCAGGGATTCGTCCAGAATATCAAAATTTAATTTTCGAACCTTTTTTCACAACAAAAAGTACTGGTACCGGAATGGGCCTCTTTAGTTGTAAAAAAATTATTGAAAAAGACCATAAAGGGATACTAGAAATTGAAAGCCACGTAGGGGAAGGGACTACATTTACCATCAAACTTCCCAAGAAATAAGGAAGCTTTCATAGGAAAGAAGTTTAGACATGGAAAATAATAGCAAAAGCAACGAAAGGCAAAATCAAACACAATGTGATACAGAAAGCGAAAACGGCTCGAAAAAGACAGTGGCCGACACGGTTCACCATGCACAACAGTCTGATATACAAGAAACTGTTGATATCGATTTTGCTACAGAAAAGAGCGATACGCCTCCACAAACAATTGCCTCTTTAGAGATTGTACCTACAGAAAAAACTAAAAACGACTCTCTATCCAAGTCGAAAACGGTGATAGATGTTCCCTCTCCCGCAAAAACAGAAAACATTCCTCTTCGCAACCCCTCCAGTAAAAACGCCGCCAACAAAAAAACAGCCCAAGATTTACCGAGGGTTAGTGACGAAGACTACGAAGATTCTTGGAGTCAAAAGGTAAAAAGTATTGGCGCCACTCTCGGAAAATCCACTAGTGGCAAAGACATCACTATCGAAAATTTAAAAGGCATCCCCAACGAAGAACGCTATGAAATCAAAAAAACGCTAGGTAAAGGTGGTATGGGTGTCGTTCTCTTAGCTAGAGACAATATTTTACAACGCGAAGTGGCGATGAAACTGATCAAAGGAAACAACATTACCGATACTTCGCGCTACCGATTTATGCGTGAAGCGCGTATTAGTGGCGTTCTCGAACACCCCAACATCATCACAATATATGACATTTCGTGTCTAGACGACTTGTATTTCACCATGCGTATGATTGGTGGCGTAACCCTCGCACATATCATTGAAGAGCTGCGCAATAAAACAGCTCAAAGTAAAGAATACACAATTGTACGGCGCTTAGAAATTGTACAAAATATATGCTATGCCTTAGAATTTGCTCATAGCAAAAAAATTATCCACCGCGATCTAAAGCCAGAAAACATTATGATTGGGGAATTTGGCGAGGTTTTGGTCCTTGATTGGGGTTTAGCAAAAAAAATTGGAGAAGCAGACGCAGAACAAGCGAGCAAAGAACTTAACCTAGATTTTACGGATGAAACAGCCCATGGCAGTATCATTGGTACGCCACGTTATATGTCACCAGAACAAGCGCAAGGCGAAACAAAGACCATAGACGAGAGCACCGATATATATTCTTTAGGGGCCATTCTCTACGAACTTTTAGTTTTAAAGCCGGCATTTACCGCAAAAAATGTACTGCAACTCATTGAAATGGTTGTAAGCACTCCTGCGGAAAAAAAACGTCTCAACAGCAATGGAGATGTCATTCCAAAAGAACTCATGGCAATCGCATTAAAAGCCATGGCCAAACAAAAATATCACCGCTATCACTCGGTGCGCCAACTGCGCGAAGATATACGGTTATTCATGGAAGGCAAATCAGTCCATGCTCTTCGCGATAATTGGTTTGCTAAACTAGAAAAGATGGTGGCCCGAAATGCCGCAATGGCTATGGTTTCCTTTCTATTTGTCGTGTTCTTGGCATGGGGATACCATTTTCTTACCGTCAATAAAGCGAGTGCTGCTGCGGGAGAACAAGCCCTAAAAATACAAAAAAAGTACTGGGTTAGTGAAGTCACAAAACAAGTAGAACTTTCGCAAAAGCGTTGGCAAGATTTATTTCAAGAGCGCTTAGACATTTTAGATGTTTTACGCAGCGAACAAAACAAAAGCTCTGCGAATAAACTACTGACAAAAGCAACCGAACTCAATGCGCGTATAGAAGAGTGTGAACAGCGCATAGAAACACTGTGTAAAAACATCTTGAATTTTTCCGCGAATGAAAAAATACAAAACATTCTCGCCCAGAACTATCTAGACAGTGCGACAAGAAAATTTCGCGAACGGGATTACACGGATTTTGCCAACATACAAGAAAAAATAGACAACGCCGTCAAATTAAATCCGCAGTTACAAACTGCGGTGAAGAATATAAAAAACCAAGGAGACGTATTCATCGCAAACTCTATGGATGAAGCGCTCACTTTGTACCGTGTGATTGACAAAGATGGATTATTTCGCCTCCAAAGTATTCCACAAATCACACAAAATAAAAAATGGCAACTCGAATTGGGTAGTTATGGACTAAAAACGCCGCAGTATTTTCTTCCGTTTATCGTCGATACACAAGGCGAACTGCGCCTTCCGATATTTCGTTTGCAAAGCAAACTAGACAACATGGTGTTTGTGCCTGGCGGAAAATTCTATGTTGGCGCGCGACTACTTGTTGATGATTACCAACATCAAGTAGACGTTAAGCCATTTTTTATTGAGGAAACAGAAGTCACATTTGGTGACTACAAACGTTTTTTTAAGGCCTTTGGTGAAGACAAACACATTCCGCGGGTCATGCTAGCAAATTCATGGGAACAGCTGTGGAACGATGATTTACAATTGCGTTTTGGCTTGCAGGACGACAATCCCGTTTTTGGAGTCAATTACTATGCGGCAAAAGATTACTGTAAATGGAAAAGTCGTATAAGCGGTGTTCGCTTTGACTTACCACGCGTCAAAGAATGGGAAAAGGCAGCACGTGGTACAGATGGGCGCACTTTTCCATGGGGAGAAAAGCAAGATTCTTCTCTCACCAATGTAGCGGTCAACCAACAATTTGGGCGTGTTGCTAAAGTAAAGAGTTTTACATATGACTGTAGTATTTACGGTGCATACGATATGGCAGGAAACGTTTCGGAGTGGACGAGTACCCGCAACGAAAATGGTAAATATCTAGTAAAAGGAAGCCATTTCAATGCGGTTCTTGATCGCGCACGTACATATGTAAGTTATGCTGTAGCGCCAGAACATGCTGGCTTTATTGGTTTTCGCTGTATATGTAGAACGGTAAAAATAAAAAAACAATGAGGAAATCATGCAAAAAAATATGTTTTTTTTCGCCTGTCCGTTGTGTCATGCTAAATTAGTAAATGAAATTGCCGAAGTAGGGGAAACTAGAAGCTGTACAAACTGCAACGGACAAATCGAGATACCAAATCCCCCAGAGCGAATACCGCCCTTTGCCCAAGTGACCAAAGTAGAACAAGCAATCGTGGCGATTTGCCCTTACTGCAAAAATATCGAAAGATTGACAAGCAAGTCGTTTGGCACTTGCATTTCTTGCTCCCAGTGCCACATACAAATTGAAATACCGCGTGTGCAGGCGGCAAAACTTCAACTCCGCTTGTCGCAAAATGCTGTTGTTGCCGATGGCAAAAGTACGGTAAGTATTACCGTGCGTACCGTCGACCGCAACAATAACCCTGTTCCCGCGCAAAAAGTACAGATATTTATTGAGCGCCAACGTGGACAAAATCAAAAGATCGCGACCACAACCAAGGATAACGGTCAAGTAACAATTGCCTATACCGCAAATGTATACAGCGGTGTCACACGCATAAAAGCGGTACTTAATGAGCAAGCGAACACCAAATGCGAACTCATCTTAAAAGAACTCAATGGTATAAAAGACGAACGCATCAAAATTGCCAAAGTAGATTTTTCCCCTCGTGATGAAAACGAAGATCTACAAGGAAAAATTACATTGGAAAATCGCAACGAAATAGATATTGATCTGTTATCTGTTGTGCTAGAACTTTCCAACGACCTACAGTGGAAATCGGACATTTCTAAGGTAAAAATTTTAGCCGGAGATAAGTATATTGTGCCATTTAGGATCGATTGCTCTCAACCGGAAATACCATCGATAAAAGCAAAAGTAAAAACCTTGGTACAGCTACCAAATGCCCGTAAAACTTTTGTCAAAGATATCGATTGCGTTGTTCCCACAAAAGGAAAAATAAATTTTGCCATACAATGTGCGCCCACACAAATGGCGGGAGAAAAATTTGCGCTAGAAATTCGCGCCATGCGCAACGAGAAATTAGTGACGTCTTTTCATAAAACCTTAGACGTGATGTTCTCTTTCGCCGCACAACAAGCCAAAAACGGCGAACAACCGCAAGCTCCACAGCAATATCAACTCAGTTTTCACGAAGGTATCGCCACTAGCGAAGAAGTGTTTTGTGCGTTTGCCTCTCAAAAAGAAGCAAAAATTACCCTAGAATATGACCAGCAAGAAGTTACCAAAAATATCGAGATAACTCCGGCACAGAAACCGCAGTTTATTTTTCATCTCACCTCGCCACAGATCAATGGTGAGTTCTTGAAAGGCAAAAATACCATTACTGTTTGCGATATATACGGTAACATCATTCACGACTTCAACAAACCGCTGACTCTAACACTTGAAAATGGAAATTTAAACAATAACAAAGACACCAAGCTACAACTCCAACCCGAAAATGGAACAATTGACTTAACGGCCGCGGAGGTTTTTTGTGTGGTAGACGATGTGTCTCAACCTGCCGCAATCTTATGTCAATGCGATGGTATTACCATACGTGACTCGTGGCAACTAGAATCCTTGCAGTGCGATGTACAGTTAGAAAATATAAAGCTAAAGAATAAACGAATACTCGAAGGAAATTCGGGCAAAATTACCCTAGAGGCATCCATATCCCCCGCAAAATTTTCGATAGAAAAAATACATATTATCTATGAAAAGACTGCGGAAGAAAACGTCAAGGTGCAGGGTGACTTCGCATATTTCAATGGTAAATTAGAAGTAAGTTTTCCCACCAAACCACGAACAATTAGTGGAGACGTTTCCATGCAGTTGGTGATGGATCTCATCAACAAAACTACCGGAGAGATAAAGGTGGTGTCTTCACAAAAAATACCGGGGTTATTCATTGAGAAAAAGGGACGTACCTTCACGACAATTTGCAACGAAGATACTTGTGCAGGGAAGCCTTTTGGAATTTCCATTGAAGCAAAATACGGAAATTTCATCGACAAAAGCTACCAAGGGGAAAAAAACCTATTTTTGTATTATGGCGCTCGTAAAGAAACCACGGATTTGCCACAAAAAATTGCTCTAGAGTTCGTAGACGGCAAAGCATATACCGGCAAAATTTTTGAATTTCAACACCGCCAACAAATTACCATTGGTGTAGAGGATTCCGAAATCGGTGGTGCAAAGGGGACTTTTTCCTGTTTAATCGCCAGTGGCGTACTCGATCACTTTGCTATACACGTAGAACCACAACTAAGTGGAAAACCTTTTACGGGAGACAATTACATTGTCGCCAAAGACAAATTTGACAATATCATAGATAGTTTTGGCGATCACGTAGGTATATCCACCGAAAATGCATACTTTTACAACGAAAATTTTTCCTCTGTCATTCCAGGAGATTACTTTGCAAATGGAAAATATCGCTTCAGTAATTTTTGCATGACGAAAATAAATATCGACGAACCATCCTACATTTCTTTGCGCTGTAATACAGTCGTCACCAAATTTCCCGTAGAACTACAACCACAACATGGAGTGTTGGTTTGTAAAAACATTGCTGCGCAAGAATCACTTGTAGAATGCGGAGATACAATTCATTTTAACTTGCACTTGTACAACAATGGCGAAACATCCATTCAAGCCAAACGCATCCTATTGGCCATCGGCGACAACACTCTATGTATAGACGAAGAAACAGAAATCAACGCCAAAGAACACTTTCGCAAAAACTATACCTTTGAACTCCGGAAAGATATTATCTCTGCCAATATAAACGTCTATCCAAGTGTTGAAACAATAGACCCGGTGACAAACGAAGAGCAAAGTTACTCCTTCGGTCACCGTTTTTGCCTACAAGTAGAGCCCAAAGACCGCACATTGCAATTCTCCATGCCTGACCAAGTCACTGCTGGTAAAAAATTTGCGTTACAAGTGCAGGTATGTCGCGAAGGCGAAACCGACGTCACCTATAACCGTAAAAGTACTTTGCAACTACAAGGGCATCCCACCACGGCGAAAACCATGATACCAGATTGCCTGGAATTAAATTTTTATCAAGGTGTCGCCAAAACCCCAGAGGTTTTTTGTTTGTATAAAAGTCAAGAGCGCTATGCCATAGACGTCGTATTACCTGGACCAGGTGGTGCAGAATCCATGCTCACCTTGCCGCAATGCAAGGCAAATCAAACAAAGACTTTCCATGTGACATGTGTACAAAAACAAGTGGCATGTCGTCCATTTGATGGAAATTTTATCGTCGAAGCTCACGACGAGTACGGTAACATCAACGAAGATTTCGCCGACAAAGTCACTCTGGAAACGATTGGTAGTGGTTCCTTGTACTTCAATAATGAACCTTGCGTAATCCATCCTCAACAATTTAACGCGGGAAAAGCGAGAATAGTCACACAAAACTTACGTTACGACTCGACACTACAAGAAACGGAAAACGTGCAAATTTTATTGCGTAGTTCACAATGTACAAGTCGTTTCCCCATTGAAATCACACCAGCTCCGGCAATTTTACAAGTCGTAAACGTTGCCATTAGCAACAAAAAAGTTCAGTGGAACGAAAGTAATTATGTTGTGTCTATTCACGTGGAAAACAATGGACAAACGCCGGCAACTATTCGCGACACCCAAATACAATTTTATATAAATGACCGTAAAGTCGACGAAGGCTACACCATCACCACCAAGAAAAAGCCACAAATTATGCCTGGAGAGCGCGGTATGTTACCGGTGCTCGTCGCACTGAATGATCAAGTACCTCTTGGAAAGCACGATATCAGTGTTCGCGTAGAATACCACGATGAATATTATGGTGTCAGTGACGCATGCACACACCGCGACGACGCATGGCAAGTCGAACCTTGTGGGCGTGAGATCATCTTTTCTACGGAAGAAAAACCGCGAATGCTAGAACAATTTGCCGCCAATTTTACGGTTATGCTCAACGGTGAAGTCGACAAAACATACAATGGCAAGCGCGTATATTTGTGTAGCTGCAAAGACAAAGTCGACAAAAAAATTCCGCGGAAGCTCAAACTTACGTTTTATGAAGGTATGGCGCAATCCGATGCAATCTTTTGTTTTCGAGAAAAGGCACAAAACGTCCAGCTAGAATTCTTAGAAATGGAAGTCGGTGGTGCCAGTGGAAAAGTACAGTTAAGTATATACCCCGAACGATGGCCTGTTGTGATCAAACGTTTTATGACTTCTGTTCAAAGATTTTGCATAGAACATCGTCGTCGTATAGTTTCTGTACTTGTCGCATTGCTAATTATACTATTAGGTTTTTGGCATTGGCAAAGGGTTAAAATTACGCAATCACTACGCATTGTATCCATATCAGGAACCGTGACAGTTGACGGAAAAGAGGTCCGTGAAAACGATCTTGTACGTCAATATCAAAATATTCAACTCGCACCAGGAGCTTTTTGTGTACTACAAACTCACAATAAAGCCACGGTAAAACTGTACAATTCTGCAAACGTCTACATAAATAGTGTAGGGCGTAGTTTAATTTCATCTACTTATGACAATGAACTAAATGTAAAAAAAGGTGATGTTAGCTATCAAAAAACCACCACCGTACAACAAGAAAGTTTTCCACGCATCGCCATTCCCGACGCCGATCGTATGGATGTAAGTAGTAATAAATTTCGCGTAGGCGTAAAAGAAAACGAAGGTTCTTTGGTTTCTGTTTATCAAGGATCTATTGGACTAACTTCCGGTGGCGAGACAGTCTCTGTAGGAGAAAATCAGGGGTCTTCTGTCAAAAAGGGACAAGCGCCCTCAACACCGCGATCTCTTCCGAAGGCACCACAGTGGATTTTACCCAATAAAGACAACGAAGTCATTTCTACAAATGCGATTCCTCTCGAATGGCGAGGATACCAGGGGATTGACCTATACAACTTAGAAGTTTTTACCCAGAAAAATCCACAAATTCCGTTGCAATCAGAAGATGTCGGTGCTGAAACGGAAAAAGTAGAACACAAATTGCGTGGTGTCGACAACGGCGTTTATTACTGCCAAGTCACCAGTATCGACCATCTTGGATTTGCCAGTGAACCAGCCATGTCAAAGTTCTTTTCCCATGAAGTGCTGGCAGAAAAGTGCGAAATAGTCATACAAGGATTCGATGTAAAATCAGGTCGTTTCATCAACATCAATAACTTCTCCATAGGAGAACAACAGTATACGAACAATAGTGAAATTACCATGGGAATACATAAAATAACTATTCGTCAACCAGGATACCACCCTTTCGAAATAGAAGCAAATTTGAACAAAGGCGAAGATTTTAAAAAACTCGATGCCAGGTTAATTCCCAAACCTCGTTCTTTAAAATGGATAATGAGTCCTGACGTTGGTGAACGGTCACAGTGTAAAATCACAAGTATCACCCAGAACAAAAAGCCTTTACAACAACTTCCAGAGAGTCTGTTACCCGAACAATATCGCTTTGACATTGAAATAGAAGGCTTTGAAAAATTTACAAAAAAAATTATCATTACTCCAGGTGAAGACGCGCAAAAAATTATCATGCCTATCATCGCCAAAAAACGTACTATTAAATACGAAATTAACACCGGGCTTAAGCAATATAAATTCAACGGTATTGTTATCTTCAACGAACAACAAAATCCACAATCCATATTGCCAGGAAAGTACACTTTGCAAATAGAACAACCCGGTTTTGTGGTCGTCAATAAAACCATAGATGTACTTCCCAAAAACACCTCGTTTACTTTACGCGAAAAAATCACCGTGAAGAAACGCGATGTGATCTTTTACGTAAAGAAAGATAGCGGCAATGTTCCACAGGCACAAATCATTGTAGAACAAGAAGAAAACAAGCGATCATTGCCGGCGGGCACCTCGCACAAACTGCATCCAGGGGAGTGGAAAATTCGCGTTGTGGCACCTGGTTGCAAGGAGATCACACAAAAAGTAAACATTCCCCCAGGAGAGCAAAGTTTTGAATACAAAGTAACAGTAGTTGCGCAAAATGTTCCACTCGAATTAAATATCGAAAACGCCGTGCCTGTCAACAATGCAAAGTTAACGGTAATTGATGCCAACAATCGCCAAATCGTTTTTCCCTACACGCGCGTATCCATGCTTCCTCCGGGAGAGTATACTCTCAAAATTTCGGCGCCCGGCTATCAACAATTTGCCCAAAAAGTTGTGTTGCGTACTGGCGAACGTAGTGTCTACAATGTAAATTTACAACCTGTTCTAGTGCGCGTACTCCCTGTAATTATAGACCCACAAAAACAGCTACAAGAGCCAATTAAAGCCATTGTCCACAACGGTACCTACAGTGAAGAACTGTTATTACCTCCCGGAAATTATACGATAATGGTCATCAGTGAGAGATATGGGGAGTTGCCAACAGAAGTAAATATAAACGTCGGTCAGGATATCTACCAAATATATGCAGACCTACCATACAACGAACGCGATTTTAGTTTCAGTGTTTATGATGTTTTGCATCTCGGCAATATGACCATTTCTTCCCCAAAAGAATTGCGCATAGATAACCAGATATATCGTTTACAAGTAAAAGAAGATGGACGAGATGTAGATACAAACAAAATAGACATTAACTCACTGGGAAGTTACGTCGTCGTCAATGCTTTCGCGCAGACACAAAAGTTGACTTTCCACATCGGATATTATAACTTAAACGTTTCTCTTGAAAACTATGAAGAAGCGATGCCGCTAATTTTTGTGAGCATAGACGTCAATAAATTTTTACAGCACCTGGAAAAAGAAAACGATATGGCGGCCAAAATAGCGCGCCTCCAAACCACCTTTCAGGTGAGCGAAATTGTCAATAATTTAGGCAAAGAGCAACGACAGTTTTTGAGAGAATTTATCATTCAATTACAAGAAGAGTCGCAACAAGATTTACGGCATTTTTTGAGGGTTCTAGGAGAATAAGACTGTGAAAAACGCGATTTTTTTATGCATTTTGTTAGGATGTCTCATGGCACAACAACACCATTTTGATACATGTAAAGCATACTGGTTTACATCGCAAACCGTTTTATGCAAACTGCCTACAGAAGCGAAAGATGGAGATGCACGTCTTTACTATGTAGAAAACGGTGGAGCCACGCTGCAAAACTTGCAACAACATCCGTTTATCACTTTGCAAGCTAGAGAATCAAATACCATAGCAGTTCCACGTTATTTGCAAAACCACATGCAATTTAACGTCGACGTTACCAATGAAAAAATTCGCCAACTAGTGCAGAAACAGCTCATTTTTGCCATTGTGCAAAAGGAGCAATGTCTATTTGCCACAGGAGTACAATTATGGTCATTATTTGATCATACTTTCCGCTATGAGGATTCTCTGGGTGTACAATTCACCAATGACAAACCGATTTTACGTCTTTGGGCCCCTAGCGCTAAGTCTGTGAAACTGCATTTATTTGATACGGTAAAAAATACCAAGCCACAGATTTTACATATGCAATATCAGCATCACGGCATGTGGCAAATACACGGAGAAAAGAACTGGAAAAACAAGTTCTACCTATACGAAGTCGAAGTTTTTGTTCCAAAAACAAATCGCGTTGAAAAAAACCTAGTCACCGATCCTTATTCGCTGAGTCTGGCACAAGACAGCACTCACAGCCACATTATTGATTTAGACGATGTAGATCTTAAGCCTGAAGGATGGGATCAGTTGCAAAAACCCTTACTCAAAGATTTTATGGATATATCACTTTACGAACTACATGTACGCGACTTTAGTATTTTGGACAGTAGTGTTCGTCCTGAATTCCGCGGTACTTTCATGGCATTCACCGACACCGATTCTTTTGCCATGCAACACTTGCAAAAGTTGTCACAGTACGGACTTACCCACGTGCATTTGCTTCCCGTTTTCGACATCGCCACCATCCATGAAGATAGACAACAACAAAAAACTTGTGAAATCCCCGAAAATCTGGCGCGCGACTCTAAAATTCCACAAGAACTCATCGGTAAGATCCGCGATGAAGATGGTTTTAATTGGGGCTATGATCCCTTTCATTACGCCGTTCCCGAAGGCAGCTATGCTGTCAATCCCCAAGGTAGCGCACGCATTAAAGAAATGCGTTCTATGGTTACGTCTCTTGCGAAAATTGGCCTACGCGTTGTGATGGATGTCGTATACAATCATACGCATTCGAGCGGACAGCACCAACGGTCGGTTCTCGATAAAATCGTTCCCGGCTACTACTATCGCTTGCAACAAAATGGTTATGTGCAAAATACCACTTGTTGCCCTGACACCGCGACAGAGCATGCGATGATGGAAAAATTGATGATCGATACTTTGGTGATATGGGCAAAATACTACAAAATAGACGGATTTCGTTTTGACCTGATGGGGCATCACACCGTCGATAATTTACACAATATCCGTCGTGCTTTGGATCAATTAACCCCAGAAAAAGACGGAGTTGACGGCAAAAAGATTTATCTCTATGGCGAAGGATGGACTTTTGGTTCACTACACAATATCTATCCGCAAAAAGTCATGAACCAAATAAACGCGCGCGGAACCGGCATCGGAACATTTAACGATCGTTTACGCGACACCGCACGCGGCGGTAATTTTGAACATCGCACCAAATCGGACCAAGGCTTTGTCACAGGTCTCTTTTACGATTACAATAATTGTGCTGACAACAGTGAGACGAGCGGCAATTTACAGCACCAACGTCAAAAATTAGTGAACTATGCCAATAATATTCGCGTTTCTTTGGCCGGAGGATTGGCGGATTTTCCACTATACCAAGACAATGACAAAACAGTGTATGGCTTTGAAATTGACTACCGCGGTGCTCCCTGTGGTTATACATCACAACCTTACGAATGCATCAACTACATTTCCGCACATGACAATTACACTTTATGGGATCAAATTTGTGCCAAGGCCCCTTTTCACAATAACAACAGAACACCAAATACCGCCACAACCACAGAACGCATCGCCATGCAAAATCTCGGTTTGAGTTTAGTCCTCTTGGGGCAGGGAATTCCGTTTATTCATGCCGGAAGCGAAATTGCACGTTCCAAGTCAGGAGATGGTGATAGCTACAACTCAGGAGATTGGTTCAACAAACTCGATTTATCCTATGCCACAAATAATTGGGGAGTTGGTATTCCATGTAAAGAGAAGAACTACCACGAATGGGATTTTTGGCGACCACGGTTACAAGACGAAAATTTACAAACAACAACTCCACACATATTAGAATGTTTTGCGCAGTTTTTGCGCGTGCTAAAGGTGCGTTATAGCTCCAAGCTATTTCGTCTACCCAACGCAAAAGAAATCAAGCGCCGCGTAAAATTCTTAAATGCAAATGCACAAAATCTTCCTGGAGTAATCGTGATGCTCATTGACAATAGTGATTTTGTATTTGACAAGCAGTACAAAAACATCGTGATGGCTTTTAACGCCGCTCCACAACAGGTAGAATTTTCACATGCATTACTCCAAGGACAATGGAAACTTCATCCTGCACTTACAGAACCTGTTTTCATCTCCGTTCGTGGAAAAAAACACCGTATTGACAGTAACTTGCGCGAAGTTGCGCACCACCAAAAACTTATACTGCCACCACGCAGCTGCACAGTTTATTTACAAGAGAGGTAGAAATTCATGAAAAAAATTGTTGTGTTAGGCGCTGGCCTTATGGGAAAGGCAATGGCCAAAGATTTAGCAAAAGACTATCAGGTTACCGCCGTTGATGTAAACCCAAAAAATTTAGAAGGATTACAGCAGCTCAATATCGAAACCAAAACCGCGGACCTTAGTCAAGCAGACACCATCAAGAGTTGCGTCGCACCATTTGACCTAGTCGTTTTAGCCGTACCGGGATTTATGGGCTTTGATGCTTTAAAAGCTGTTATCGAAGCCAAAAAAGATGTGGCAGACATTTCTTTTTGCGAAGAAGATTTCTTTTTGTTAGACGATTTAGCAAAAGAAAACGGTGTGACCGCCGTGGTCGATTGCGGTGTGGCACCTGGTTTAGGAAACATCATACTCGGACACCATACGCAAAACATGCAAATAGATAACTTCGAGTGTCTCGTAGGTGGATTACCCACCAGAAGATCGTGGCCATACGAGTACAAGGCGCCTTTTTCTCCCATAGACGTTATTGAAGAATACACAAGACCTGCGCGTATTATGGAAAATGGACAAATTGTCATCAAAGAGGCGTTATCTGAAACCGAACACGTGGAATTTCCCGAAATTGGTACGTTGGAATCTTTCAATAGCGATGGCCTACGCACTTTACTCAAAACCATGCAAATTCCCAACATGAAAGAAAAGACACTGCGCTACCCAGGTAGACATATTGAGTATATGAAGGTACTGCGTGAAACCGGACTTTTTTCCAAAGAAGAAATTTCGGTGAAAGGTAATAAAATACGCCCCATCGATCTCACTGCGCAATTGCTATTCCCGAAATGGAAATTTGAGGAAAAAGAACACGATTTTACCGTAATGCGCATCACCATAGAGGGTAAGGAAAACGGTGAGAACAAAAAGTATGTATACAATATGCTAGATCGTTATTGCAGTGAAACAGATACAACATCCATGGCAAAAACAACTGGATATACCTGCACAGGAGCTGCGCGACTAATCGCCGAAGGACACTTCACCCGCAAAGGTATTTGCCCTCCAGAGTACGTTGGACAACATGAAGATTGTCTGACGAAAATACTTGCGCATCTAAAAGAGAGAAATGTAAATGTTGATTTGCAGCAAGATATTTAAGAATCGTTCATTTACCTAGTTCACAGGAACTGAGGTGGAATGTAGGGGCGGACCTTGTGTCCGCCCTTTCCCCAAAATACAGTTAGATCAACATTTTGAATTACCAGCAAATCTCCTGGTTGAAGTTTTAGTAATTAAGGTCTACGGATAGAATTCCGTTAAAACCAGGCTCGTTGTTACCCGAACCGTGAACACGGTAATCTTTGTCGGTAATATTTTCAATGGCAGCGCTTACCGTAATATTATCGGTAATACGCGCTCCCGCTCTCACCGTATAAAGAGTGTAACCCGGCGTTCCTCCAGGAGGGATACGCTGCGTATCGGCGGCATCGCGTGTTGACAGGCGATCCTGCCCTCTCACCATGGTGACAACCCCCTCGGCCCAATATCTTCGCGAAGGATGATTCCAACGCAGTCCGACAAACCCCTGTGCGGGTTGCATACGGTCAATCGGTTCATCTTCTTTGTTGCTATTTGCTTCGGGAAATGTGGAAACAATACCTTCCATCCACGCAAATCCACCAAACACCTGCCACTGAGGAGTGATGTTATAGCCGGCTTCAAATTCAACACCGTGGACAAATCCATCCCCTTCGTTGTCTTTGGTTACCTCCACTTCGCCATTGATGATATTTCCCGTAGGAAAACGGATGATCATATTGTCGATTTGTGTATAGTAGTACGATCCCTGGAAGAACCAATTCGAATATTGTGCTTTTAGACCTATTTCGTAAGAAATAAAGTATTCGGGGTCTAGTTCATCTACCGGAGTTTCTATTTCGTTAGAGCGCGCACTGTTAAAACGCGTTAAGTCAGAAAGACCAGGGGAACGAAAACTCTGTGACACCCCGCCAAAGATATTCCAATTGGCATTGAGGGCCCATACGAATTTTAAACTACCAATAAAACCACCCCAGTCATCTTCAATAGACACCTCGTTACCTGTCAGCGGGTCCTCAACTTCCCCAGCTTCCAGCCATGAATGGGTGTAACGCACTCCGGGAATAATCGTAAATTGCTCGTGAATGGGCATTTCCCATTGAACATAAACGCCTAATGTGTCGTAGGTGGAATCGTCGGCAACAGGTCCCTGAATTCTTCGGCGATTAAAGGTTCCATCGGCGTTGAAGTCTTCGCGAAAAGAGCGCACAAAATCACGGTAATACTCACCACCATAAATCAGCTGACCAAACCCCACATTACTGGCAAAACGCGCCAGAAAACCAACGGTGTTTGTGGTGATTCCTTGGATGTCGCGACGTCCGTCACCGCGAATACGGTCTTGTTCCTCTGCTTGGTAGTGCCACGAAACGGTAAAAGTGGCATTGTCAAAAAAATCTTCCAAGTCATACATGCGGTATTGAATGTATGTTAAATGACGATCGTGGTCGGTACGACGACGTAGTTCATTTCCCACAGCCGAACCGCGAAAACTTTTGGCAAAAATGGTTTTGTGTGTTCTTTCGGCGTCATTTTGGTTCACACCATAGTAACCAAAAACCAGCTCTTCGTGATTGGAGAGAAACCAATTGAGTTTAAAGTCTCCTCCCATTTCGAGGTAGCCAGTTTTGTCAAGCTCATTGCTGTCACCACCAGCGATAATATTGCCAAATTTTTTATAGAATACGCCCCCCACAAAACCAAAATCGTAGCCATAGTTTCCCGAAATTTCACCGCGCGCCATATGTGATTGTTCGCCGCTGGAATATCGGTAAAACAAACGCGAATTGAGAAGTGAGTCATCACCATATCTTTCGCGTTCGCGCGTAATGGTATTGATCACCCCGCCCACAGCGTCCGAACCGTAAATCAGGGAACCCGGCCCTTTGACAATTTCGAGTCTTTCTACGGCGAAAAAATCCACGGTATTCCAGTATTGGTTAGGCCCTTCGCGAAAAATAGAGTTATTGAGTCGTATTCCATCAATGAGAAACAAGTTGCGAAATCCAGTAAATCCACGAATAAAAGGAGAACCTTGGCTATGTGCTGTCTTTTGTACCATCACTCCGGGAGTTTGTTTCAGAGCTTCCGGTATAGAGCGTACCATGCGTTCGTTGATGAGTACTTCGTGGTCAAGGCTATAGACAACACTTGGTAGGTCGAACTTCTTACTCTCTTGCGTATCAGGTGTCACCACAGTTTCGTTTAACGCCCAATTGTCATTTTCCACACTTTCGGCATTTTTTTCCTCTTGGGCTTTTTTTTGTTCTTCAACAGCCTGCTTGCGCTTCATATTGCTATTGGGAATGATCTCAAACTCAGGCTTTTTTTCATGTGGTGTTTTTTGCACATCGGATTGTTTTTCCGGTAAATTTTGCTTTTCTTGAACTTCTTGTTCTTCTAGTTCTAGAGGCTCATCAAAGATGACATCATCATCTGCGAAAATACACAACATCGTGCAAAAAATTAATAGTAGTAACTTCATACTTTTCTTCCTAAAATATCATTATGGATACCATTCTCAACTTGCTGCGTCTCATTTCTTCGCTTTAAAGGTTGTCAGATAAGTTTTTTTAGAAAAATACATTTTCGCATGAACTTATCCGATTATTTTACGTATACGAAATAAAATAACGATAGTTCACGTGAAAATATATTTTTTTGGAAAACGACATGAAAGCACACAAAAGTATCCTCATCTCCCTAGCGATTCACTTAGCGATTTTTGGCGTGTCGTTCACCATATTTGTCGGGCAAAAACAAAAAAGTAAGACCCCGATAAGTTACAATATCCAAATACACGTAGCGCGCACCACACATCTGCGCGACAACCTACACATGACTCCCACAGTTTTTGAACCCAAAATCAACGACCCACGAAGTTCTCATGTCGACATCACACAGCAAAAAGACGACTTCGCGCAACCCATCGTAGAGCGTGAACAGCGTCCTGTCAAAAACTACGAACGCTTTGGTACTCTGCGCCTAACACCCAAAAAGCCAAAAACAAAACCACAAAAAAATATCGCCAAGAGCACCGTTAAGCCGCCAAAACAAAAAACGGCCACCAATAACAAGAAATCCTCGGCAGTGGTCACCTCCAAAAACTCCGGTGGAAAGTCGCAAAGCGCTGGTGGACAACCGACAGCCGGTGGCTCGCGTTCCCATAATCCTCATGGTGATAATACTGCTGGAAAAAGAGCTGGTGCAAGAGGTGGCAGCGCTGCTGGTGGGGGAAGTACCGCGGGTGTTCCTGCGAAGATAGAAAGACCCAAGCTACGTAAGAAATACAAAATAGACTACCCGCAAGCCGCGAAAAGATTACGGCTATCGGGAAGTCTTATGTTAAAAATTAAGATTTTAAAAGATGGACGTGTCGACCAAGTTGAGATCGTCAAAGGCAGTGGAATGCGCATGCTAGACAAGGCGGCAATGAAGTCGGTAAAGACATGGTTGTTCTATCCCGCCACCAAAAACGGTAACCCTGTCAATTCGTGGATTAAGGTGCCTATTACATTTCGTTTGTAAATGTTTTGTCTCTAGTAGGAGTAGGTTTTTTAAGCTCTTTTACTAACAAACCCCCAGGTTGTTCTCTGGAACCACAAAACCACCATCGGAGTGTCATCCCTGACTTGATCAGGGATCCAGCGCTTTGAAGTTTACTTTATATTGTAGATTCCTGCTTTCGCAGGAATGACACCCCTGGGGAAAATTTAGTTTGAAACAACCTAACACCTATAGGAAAAGACTCCACTGGTATTCGGTCTATGCTGAATTAGCATACCAAGCTGCTATACCTATCATTGCATGCAATAGAGGCTAAACCCATCGCGACACTTTCGAATAAAAACTCCGTTTCTACTATTTGTGCTTGCGTGAAGTAACTCTTTAGCAAGTCTTGGAAATAGGCGATTTGCGTTGTCCCTCCGATGAGCACCACTTTGTTGACTTCGTCGCTATTCATCTGCGCGCTATTCATCAAAACAGCAAAGGCATCGAGAATGTCACTTTTGTAGAAAGAAAGTATCTCGTTGAACTCGTCTTGCGTTAGCTTTTCCTTGATTTCACGGTTGGCAATATCTAGATCAATGTCCACTTGTGGTTGGCTAGACAGTTTTATTTTCGCGGACTCCATTGCGGCAAAGATATGATGATACAACTTTTTCTGTATGCAGTCTTTTAGAAAACGCAACTCGGGGATATCGGCTTCCGCATCCCATAAGATTCGCTCTATCTCTTCGAGGATTCCTTGGTCGCGTGAACGATTCAAATCATCATCTAACAATAAAAACGGTAAAGAGTTTGGTACCAACACATTGTTACTTTTGTTATTCTTACGGTCGAGCATTTTACTGTTGTATGTCACACCCAGGCCAAAATGTTGTAGCACTTTGTGCTCGATCATTTTTTTGGTGATGTCGTGGCCTCCTAGTTTAATTCCGTGTGTTGCGAGAGGACGGATATCAAAACGCGAATGAAATTCAATCAAGTGAAAATCTAGCGTACTTCCGCCAAAGTCAAAGACAAGGGCAATATCCCCTTCGCGAAACTGCTGCAAATTGTTCACCATTGCCGCCACTGGCTCGTACACAAAAGACACTTTGCGAAACCCACTGCGCCACGCCGCTTTTTTCAAAAACGTTTTTGCTTGTTCGTTTAAATCGTCCACGGTACAAAAATTCACCGGAATTCCAATCACCACTTCACTACATTCTTGCCCGACATGTCGATCTCCGACTTTTTTCACAAACGAAATATAGTCGCAAACAATATCGACATAAGGCTTTTTCTTATCCACAACAAATGTACTATCGCTTCCCTCGATAGCTAACGCTGATTTGACGTTGCGAATAAAGCGTCCCTTGTCAGCAATAGAGTTGAGCATCATATACGCCGCATCATTGCCCATATAGCTTTCGTACTGCGTATAATATAGCAACGTAGGCAAACTGCAAGAGGACTCGGAAAGCTTGATTACATCTAGTTTGTCATTCCAAAAAACAGACAAAACGGTATTTGAGGCTCCAAAATCTAAGCCATATACAACATTTGTAGAATTCGACATAACGCACTCCTTTAATAAAGCGTCCGCTTCTTCTCTACAAAGAAACAAACTTTCCACACCAATAGAAAATTAAGCTTTAGGCCAGAAGTTAAGACACAACAACAAATGTACAAATGCAAAATACCATAACAAAACGAAGGGAACACAACGTGTCATTAGAAGGAGAAAACAGGCTTGTGTAGCAAAAGAAGCTGTTTTGCGAAGATGAAGTCCAAGTTTACGGATGAAGATAACAGTATTTGTAGTTGTACATTCTCGGGATGTTGTTTAACGCGCCTTCGCTGCAAAACAGCAGACCTATTTGCTTTATCCAATAATCCCGATAGATCGCTACATGTTTACCTTCCGAAAAGTGAATAACGAAATGCACCACTGGACTTCTATATAGATTAGATGAGTTTGTGGTAGGCAAAAGCTGTAACACATTTTTTACAGCGTGAAGAAAATAACACATAATAGGTGAAAAATCAAAACAAAAAACCACGGAATTGTGGTGAAATGTAGGGGCGGACCTAGTGTCCGCCCGTTCCCCAAATACAGTTCGACACACGTTTCTGAAGTACTAATAAAAAAATATCATTCAAAATATATAGAACAATTCGGCAACAATTTTTGCAGCCACTCTACTTGCGAACGTGTTATTGAGTTCATGTATAATTCCAGAGAGTGAAGCTTCTGTAACTTTCCTATTTCCACAGGGATTTCCTTTAGCTCGTTGCGCGATAAATCCAGCGTCATTAGATTGGTTAAATTTCCTATTTCTGCCGGCAGTTCTTTTAAGTTGTTATTCGACAAATCTAAATGGGGAATGTTCGTTAAATTTCCTATTTCTGTTGGTAATGTTTCTAAATAATTACCATGTAACTCTAACTCCTCTAGATTTCTCAAATTTCCTATCTCGCGAGGCAAGTTTCTCAAGTTACTATTCGACAGATTCAAATGTGAAAGATTTGTCAAATTTTCTATTTCCACAGGTAACCGATCAAAATGGTTCCCGTGCAAATCTAATTCCTTCAGATTTGTCAAATTTCCTATTGCCCCAGGTAGCTCACTCAATTTAAGATGCTCCAAGTTTAAATAGGTAAGATTTCTCAGTTTTCCTATTTCTTTTGGTAGTTTCTCTATCTGGTTACGTGACACATCAAGGGTAATCATCTTAGTAAAATTTCCTATAATCGCTGGCAAATCCTTTAAGAGGTTTTGCTTCAATGATAAACCAGTAAGATCAACAAAATTCTTGATCTCCATAGGAAATGCAGTAAGTTCCCTATTGTCAAAATGCAACTCAAACTCATCTGAGAATCCACAGTTTTCGAAATGACAATTAGACGCGTTTAATGCCACACTACTTCTAAAACTACAATCAGAGAAATGAGAGTTTTCTATATAATACAAATTATTTTCGTCCAAATAAAATGCGCAACATACATAAGAGGTATCACTTTCAATTTCTTGGAGTGATTCATTTTCAACTGTTTTCAAAAAATATTCTCCATATGGCAGAACTATTCATTTAAAACTAAACCCAATACTTCGAAAATACTACAACACCATATGGTAAAAAAACTATTCTATTTTTAACTTAATTTATCACTCGAATTGCCTCATTCGTCAATCATTTTTGCAACTTTTTTTGCTGTATTCCTTAATATATAAGACATTTCTTTTTGAATTCGTCAGTCATTTATGAGGCAATTCTCAATATCAAAAATTCTATTAAAAATCATATTTCTTTGACAAAATTTCAACTTTGGCACGTTCAGTTCGGTTTACTTTTCTTCCCACTTCTTTATATACTCCTGCATTTTTTCCTTTTGTCCAAGACGTCGATAACAAAGAAACAGGTGATGATACGTTTTTTTATGCCGGGGATTTAACGTGATCACTGTATGAAAGTCCTCTAATGCCTTTTTGGTATCTTCCATTTCGTAAAACAAAACCCCTCTGTGCAAATACCCCGCAAAGTTTTTACTATCGTGTTTGACCACTAAATTGAAATCCGCAAGCGCTTTGTCGTATTTTTGTAAATGGCGATATAGCACACCGCGCTGCACATATGCTCCCCAAAATTTAGGATTTATCGCAATGGCTTGGCTGAAGTTTCTTTCCGCTTTCACAAACTGTTTTTTATTGACATAAATCACCCCACGCTGAAAATACGCGCGAAAATACTTTGCATCCACTTTAATCGCATGGCTAAAGTTCTGTAAACCCACGTCTGCTTTGTTCAACTTGCGATATGTGAGACCTTTCCAAAAGTACGCATGCACATATTCAGGAACGATCGATAGTACTTTGCTAAAATCAGCAAGCGCTTCCTGATATTTTGCTAAATCATAGTATACTTGACCGCGATTATAGTATGCCTTGTAGTAAGACGGATGTAATTTGATCACCTGGGTATAGTCGGAGATGGCTCGATGAGGTTTTGCCTTTTGAAAAAGAACACCACGGTTAAAAAACGCAAAGTAATGGTTAGCATCTAGCGCAATCGCGCGATTATAATCGGCGATCGCTTTTTTTCTCTTGCCCAGTCTCTCGTATGCTTTACCGCGGTTTGTGTACATAAAATGATTTTTCACTTTTTGAAGAATTGCGGTGTAGTCTTTTACCGCTTGTAAGAGATCTTTTTCATGGTGACTTTCCAATAAGACATATCCGCGAAGAATCCGGTATTGATCGGCAGTTTGTAATTCAAGCGACTGTGCAAAAACGTCTCTCACAGGTTTTAAAAATTGGGCATCGCGAAATAAATCCACATGGCGATTTTGCCGCGAGATATATGTCAAAGATTGCAGCATCGCTTCGTTTAGCTTTTGTAATTTTTCAGAAGACTGGTCAGCTTCTTCGAGAGCAACCTGTAACTTTTGTGCCGTTTGATCGGCTTTTTTCAGGGCACCCAACGTCACAAATAGAGAGATCACGAGAGTAAGAAAAATGATCACGACACTCGTGAGCGCGAACCGGTGACGATTAAAAAATTTGTAAAATGCGTCCCACTTCGTATATTTCTTTGCGGTAATAGGTCGATTTGACTTAAAGTTTTTTAACTCGGTGTGTAGTTCTGTAAAACTTTGGTATCTCTTTTTTCTTCTTTTTTGCAAACACTTTATGCATATCGCTTCCAAATAAGGTGATATCTGCGGACGAATCTGTCGCAAAGGGATAAAGTCATTGCGAATGATCTTATAAAAAATATTCATCTGATTATCCCCTTGGTACATCGTTCGATACGTCAAGGCCTCATACATCGTTGCTCCCACGGAATAGATGTCACTGGCATAGGTCGCTTTTCCTAAAACTTGTTCAGGAGCCATATAATGAATCGAGCCGATAATCGTTCCACTTTGCGATAAATTCTGGCGATGGGCACTATCAATTTTCGCCACCCCAAAATCCATCACCTTTACCACCCCCTGCGTATCGATCAAAATATTGGAGGGTTTAATATCGCGGTGTATAATGTTGCATTGGTGCGCATGTTCCAACGCTTTGCAAATTTGCATCATCACCTCCACCAACCACAAAGACTTCACATTATGCTCTTTGATCTTTTTGTCAAGTGTACAACCTTCGATATACTCCATGGTAAAGTAAGGTTTTGGTGTGGTGGAAAATTCATAAAAACGAACGATATTTGGATGATTAAGACGTGCAAGAGCTTTAATCTCTTGGGAAAAACGCTCATAGTCGTCTTGGGAAAAACCTTCTTTGGTGATTAGCTTCAAAGCAACATAAATATCGTATTGTGTATCGTAGGCTTTATAAACAACTCCCATGCCTCCACGACCAAGTTCTTTCTCGATGATATATTTGCCAAAGTTAGCCGTATTTGAATTTTGATGGTTCAATGGAATCTCTCTTTTTTACTTAACTAAAAAAAAATATGCAAAGCCGACATTTATGTGACATACTATATGCATAATAACTACATTCATACATTTATGATTTGGTAAAAATTATATCGAAACGATATAACCCAAAAGGTTGCAAATCTTTTTGGTTGTATTCTACTTCAGACATTTGAATACCTTTATATTTCATACCAAATGTCGTTGTAGGCTGTTTTTATATATATTACCAATATATCCTTAGTTAAGGAGCGTATAATGTATGGACACATATTCGCAATTATATTTTTAATTTTTATTATACTAAGTTGTTACATCGTAAAGAAATATGCGACAAAGTTTAGCATCAAAAATTCTCTTTATGGCATATTATTTACAACACTTATGGTTTTTGTGTGGGCAATGACTTCTCCGTGCTTATGTAGAGAACGTGTCCCGCTAATATTAATAGTACTTCCTGCTCTTTTTATTTTAGTAATTTCTGCCGCTGTTCCACAAAGAAAAATACGTAAAATTTGTTGTTACTCCATTGCAATCACAGCATTTATCCTAACAGAATTTCACGCAACATTGCATCATGGAGGTGGCTACACAAGTCGACAGAACTACGCACAGGTAAAAAAAGAGGAACGTAAATACATCATGTTGAGTTACATAAAGTATTTACCATACACAGTTGAATACAAAAAATATCCTGCGGGTTGGGTGAAAGATATGAATCTACCACTAGATGAAAAAATCATACAGTCGTTTGATATTTCATTGCCGGAAGGAGTGGTGACACATTGGCACTCGTTTTTCACTTCTTTATACAAAAAGAAACCGGAAAAAAACTACAGCTTGTGGTTCCCTGGGGGTATTTTTGAAAAGCACATCACCAAAGCGCACCTAAAAGCCTACGAGTAATCTTACTGCACTAATATAATAAAGTTTGCCCCTTTTATGGGGCAAACTCTACACGGAAACAAAACTCCACAAATCTACCACTTCAAAGTATCAATGTGCGTCTCTTCTTTTGAAGATGTTAACATTGTATAAAAACTACGTGTTCGCGCGTCACGAGAACCACTATGTGTGGTGATGGTTGTCTCGACAAAGGTAATGTCACTAATGCGCGCCTCATTGGAGCGAAAGTAATTTACCTTTATCTTATATTCACCTGCCGCTGCTTTTTTCAAAGCGTAGCGTTCTGGTCCGTATCCTTGGGTCACATCGTCGGAAATTTGTCCACCACTGCGGGTATTTTTATTTTCATAGTAACATTTTTCTCCGCTTGGCTCAATAACCCACAGATCCACGTCGGTGTCATTTGTTGTCCAGGTGATGGTAACGGTGATGTCATTGTGTTGTGTGGTTTTTTCGGCAATAGATTGCAACCTCTTTTGAAAGAATGATTCACGGGTTTCTTGGGTAATTTTGCGCAAGATATGTGCGTATTCTTCTTGCGCAATACTATTGATTTGACGAAAACGTTCGTTCCAAGTTCCCGAAATGAGTATTTCGTAATACAAAGCGGCAATGTGGTATTTTTCTAGTGCCGCGTAACTTTTGGCCAAATCTCGATATACTTGTGGTTCGAAAGGACGTTTATCGCGCACTCTGGTAAAAATCGACACTGCGTGAGAGGCGACTTGCTCTTTCAACAACAAATAACCAGCGACACGTAATGCAGAACTTTCTTGAGACTTTAACTCCACGATCGAACTCACCGCACGCAAGTAACCACTTAAATTTCTCTTGGCGTCATAACTTTGAGCTTTTTTGATATAAAAGAGGAAGTTCTCAGACGCACCTTCTTTTTGAGAGGAAAAATCATAGCGTAGCTTTTGTGGTGAGAAAGTAAAATGCGTATCATCCAAAAGTGAGAGTAGTTCTTCGACATTCTGCGGGTTGAGTTTCACGAGCTCGTTGTCTTTAAGAGTTTCCCAAAAATACATAAAGCTATTTTTGGGAGAAGAAATACTTTTTTCCAAAGAAGCATCTATGTTTTCTAGCACCTGCTTTACCATGGTGTTTTCAATTTTTTGACTGTCTTTTTGCAAATTCACATTGAACTCTTGGTAATCTTCTTGCGACTCTAACATCAACAAGGAACACGTTTTTCCAGGAATCGAAAAATATCTGGCGTAGGCAACAATGGTTTCCTCAAGAGCGGGGTCCTCTAAACTTTCCATTTTGCGCACCACTAATTCACCAAATGCCCTTGGTGCTAAAGAGCCTGAAGATTTTGTGGGTACAGTAAACACAAAACTTTTGCGTTGTGTACCTATACGACCGGTTATGGTGATGCGCGCTTCGTTACCCGTTATTTTGCCCGCAAGAAGAATGCGCTGTCCAGGATAAAGTACTTTGACACTTCCCGCGGTCACGAGATCGCTAATTCCCTCACCATAAATGTTTTCCACAAACAGCGTACTGCGACGATGTGCAACGGCCAACTCATCTAGTTGCATTGTACTAGAAAAACTTCCCCCACCAAATTCATTCAGTAGGTCAAAAAGCACGGTATTGGCTGTTCCTAGGCCGAGATTATAGCAGAAAAAATGCGGAGAAAACTGTAACTTTTGGCGAAATTTTGCCATACTTTTGCGCAACGAAAGTTCTCCCCAGTTGTGCTGGCCATTGCTGAGAAAAAAAACATCTACGTTGGCATTTTGTTCATTTAACCACGGAGTGTCGACCATGTGTTGTAATGCTTGCGTAACATCGGTGGCGCCTTCGAGGTGCATCACCTGCGTTTTATCGCGAAATAGCGCCAAACCAACTGGACTATTAGCAATCCAACCATCTTGTAACCAACCACTACTTACGTCAAAAAACAATACGTTAAATTCTTCGATGTCGCGATTGCGCTCTAGTATTTTCTCCAAAAGTGCAACATACATTCCAAATTCTTGTTTCTCCTGACTCAGCGATGTATCTAGCAAAAAAATCGCACGCTTCGAACGCGAATTGTATTGCGGTGAGGAAAACTGCGGAGAGACATAACCGTAACTGTAAGTAATGCCCTGTTTCTCATCTTGGCTGGTAATAAATTTTTGTGTTAGGTTTGCGCGGAACACAACGTTTTTATTGCGTACGCGCGTTTGATACGAAACGAATTCGTCACTTTCACTTGCAGGAGTCGCCACATTCATCTGTGAACTTTCGATATAACTTTTATCGGCGACCAACATGAAATCGCTATCAACATCCGCACAAGAAAATTGATAGGTAATCACATCTTCCACATCTATTAACGTCTGTTCATAACCAATTACAATGCGATAGTACTGGTTGGCTTGAAGGGGAAATACACGTGTGATAAAAACATTTCCTCCGGCCCACTCCACAAGAGCAGGGTCAACTCCACGCCGCACAACGGCCTCATAAGCTTGAAGTGCCTTTTGTCGCGGCACAGCATGCGCAATTTTCGCTTTGCCAAAGTTGCTTTCCTCTTCAGCAAAATAGTCTTCTATCTTCTTACGGTGTATTTGGGCAGCGGTAGGTAAACTGGGAAGAGCCACTTCTTTATCGGAGTCTTTACTTACAAAGCCTTCTGGATAAAATGCAAAGTAGCAAATGCTGGCATTGTCGGGCAATTTATAACGAAAATCTCCTTCCAGAGTGCGCTCATAAGAGTTATGGAATACATGATCCACAACTGTACGCGTACGGATTCCTTCCACAGAAACGAGCGTACGTACGGACTTCAATTCCAAAAACTCATCGTTACCCACACGGACTTGCGCCACGTTGGTGTCTTTTTTGTTGCGTACCCATTTTTTCGCATCTTGTTTTTGCCCTGTCTCTTTATCTTTTTCTGTGATCTTTCCATCACTTTCTAATTCAATACTGTCCCCATCGCCTTCTACGAGAGAATCTTCTTCCTCTCCATTATCAAATAAACGAAGTCCCAAGGGTTGAGCATCTACAATCCTTTTGCTATTTGTTAATTGCAAGTCGGCACTTTTTTCTGTAGAACAACTCATCATAAATGAACATATTATTACAACCAAGATTCGAAGTGGCATGTTTTCTCCTTGTCATTTTTTATACTTTTTTCAGATAATATACCAAAGAAGTGTCATATATTTGTCATCGTTTCATCATATTACCAACAGTTTTATATAATGTCTTCATAACTACTAGGGATTTCATATTATGAGTACAAACTACCAACAGGCATGTGCCATTCCGTATCGCATGGAAGACAAAGCCATCTATTTCTGCTTAATCACCTCACGTAATCACGGCGACTGGATTTTTCCGAAGGGATGTATTGATGGAGAGGAAACACCACAGGAAACCGCACTCAAGGAAGCCAATGAAGAGGCGGGTCTTGAAGGAGAGATTGTTACGGACTTAGGGGCGTTCACTTATCACAAAAGAGGATTTGATCTTCTAACTTCGGTGCAACTCATGAGGGTAACGCACTGTAAAAATACGTGGCTAGAGCTAGATCGAAAACGCTGTTGGGTTTCGTCATCAAAAGCACAAAAGAGGATAGAGCGCGTTGAAATGCAAAAAGCTTTACAAAAAGCAATTGATTGGCTCTCCCAGCAACAAACTCACAACCAGAATCAATAGCCAGGAGGCCAATCCACGAAGGTTTCTTTAGAATTGTGCTGAATTGCAGTAATGCTTTATGTCCTTGTAGATTTCTTTTACTAGAGAACTTACATTGCTCGGAGGATGAAGAATATAACTCTTGATCGTTTTTGCCCAGTGATTAATCTCTCGGACTTTTTGCTCTTCGTAATCGATATTGGCTAGGTCACAATAAAAACGCGGCAATTCTAAAAAATCCACATAACGCACTTCCATATTGCGCGGGATTTTCTTACTTGATTTACGGCTAGCGATCATAGACAAAGGAACGATATCATTTTTTGGTTTTCCCAATAAATAGCAAATATATAGAACATTATTCTTTAACGCCATGTTGGCTTGTCCATCCTCATCGTAGTGCAAGAATGGTTTTTCGACAGCTTCTTCGGGGAGCCAAGTATCAAAAAAGGTGATTTGGCTTTGTTCTTTAGAGAAGGGATCACTCTCAAAAAGAGGTAAGTATTTGTAAATGGCGATCGGTGCTGCTGAAACACATAGCTTGATATCCAATAGAAAAAATCGACCGTTTTGGATCAGAGACCTCTCCACATAAAAAGAGTCCGGGCGCAGTGTTTTTCCCGCTACCTTAAAACTCTGTTCTTGCCAACCAATCGCAAATATACTCTTGATTTTTTTTTCCAATAGGTGCAACGAGCGGCTAAACATCGCAAGGGTATAACGATCCAGGGGATGGGGTAAATTGATTTCATCCAAAATTTCATTCCATTTTTTACCACTGCGCTTTATCAATGTTTGCGAAACCGGCATCTCGGTTGTACGATAATAATCGTATTGATTTGCGGTAATAGTTCCCGTTACTTCGCGTAGCGGGCGATACACATCTAGAACTAGATTACTTGCTTCTTTACGATTTATCATTCTCATTTTCTTTTACTAAAATCTTTGTATTTGTGTGTTTACGGTATATTCAATTGTAAATCATGATCATGTCCAGATGCAAAAATAAATAAATTTTATTCTCCATTTCAAATTTAAAGTAATTGTTATAAGAGGATATTTGTTATAATAAAATTTAAATCTTATAGAATCGTAAAACAAATATTTGTACATATTGGATTTACAGTTCCGTAGTAGTTCTAAAAACTTTGGTTTAGGAGGGTGGCTGTTTCGCCATGTGTTGTGTATGAAAAAATTTAAAGCAAAAACCAAAAAACGCATTATATACACTGTATTAACAACTTTTATATTCGCAATTGGCGTTTTTTTTGATGTATTCTCTATCGCGACAAAAGGACTTGACGCCTACAAAGACTATCAAGTTACCACAAGTATGAACAAAATAGAGAATTTTCAACAAGATGAAGATCTCAATAAAGAAATTGCAAAACTCAGTACACAAAAACAAAAATTAGAGACAAAGCAGGCTCAATGTCTAAGTGCAATCAACATACTTGATGGAAAAATACAAGAGCTAGCGACTGATAAAGACACTTTTAAATTGGGAACAGCGGAAATCAACAAAGAATCTGCTCAAAAATTGCACAAGCAACTTACAAATAGACATAAAAATTTGACCAAGAAGGTTGAGTATGTAAATACTATTTTAGTTGCGAAACAAGAACAATTTAGAAAAGCAAATGCTATTCGCGATCAACTAGAGGAAGATGGACTTGAAATTCAAATGCAGAAGTTAGAAATAGAAAAACTGCAAAAAGAAATTACAGATTTACAAAAGCAAGTTCAGGAAAAACAAGATTACATCAATCAAAAAGCGCAAGATATTAGCAATGAAGACAGTGCGCAACAAGAAGCAGATATCGACAACGTTATTTTCAATATCAACAGTAAGTAATTTCGTCCGCAATTCCTCAGTAATTGAGGAATTGCAGAACACACTATTTTAAATCTTCTTTCTTTACAATGATAAAACGTATTTTACCAAGTAACTTCTTAAACTTTTTTACAGGTACCTCCGCATCAATTTTGCGAATGGCCTTCTTACTTTTGCCAACACTTGCCAAGAATTTTTTGATCTCTTTTTTCTTCTTAAACCTCTTAAACATTCTCGCTAAAGCTTTATCACTCGCAAAAGAAGCGTTCACATCTTGTGCTTTTTTTTGCATACTTAAATAATCTTTTCTCTCTTTTTGCAAGTCGTTTTTAATGCGCTCTAGCAATTGTGCATCCTTTGGATGCAAACGGAATTCTTTATAACCTTTTACAAGGTTTAATATCTTATTCATATCTTGAACAAGATATCGTATAAAATTGGGAAAATCTTTCATTTTACCGAGATGTTCTTCAAACTTGTCCTGTAGATCCGCATACGATTTTTCTCCGCGAAGTTTAGCAACCATATCCTTTTCTAAATATTCTTGTAAATCGTCGTAAAGTCCTTCCAATTCGTTGATCGCTTTATCAGACTTTAGACAATTTCGAATGTTATCGAAGGCTCTGCGTTTAATTTTATTAATCTTGGGTAAAACTTCTTTTTTAAACCTTTTCTCTTGTTTTTCGCGATATATCTTTGCCTTAACTTCCTTCTCTTCTTCTTTGAAGTCTTTAACGAAACTCTCATATGCTTTGTTTTGCTCGTCGATAACGTATTCGTAACGAAAACGGGGATAGGTAATTTCAACCTCCCAACCTATCGAATTACTATTAAAAACTCTTTTCACTTTTTGTTTTTCGATGATTTTCGTTTCAATTTCCTTGGCAACTTTTTCTACCAATTCTTCTAGTTTTTTGATATTCTCCGAAAAGTCGTTGACAAGCTGTTGTTTTTCTTCAAAATTCTTTTTATCGGTGCTGAGTAGATCCAACATTTCTTCAATATCTTTCTCTGCTGTGTCAACAAATTCCTTCAGAGATAGATGGTCCTTTAACGTTGTTTTTTTGCCACTATCGACAAAAAGTTTTTCTACTTCATCAGGAATATTATCGCCATTGATACTGACTTTCACCGTTTCTTTTGCAAACTTCATTATTTCAGATTTGTCAATAAAACTAATTTCAAAATCCTGTGCCACAACGATTGGAACAGCTAAAAATGCGATACATACGATCAAAGTTCTCATAATATTTACCTCTACCTATTATTCCACTGTACGCCCGGGAAGATACGTGCGCAATTTATCGATGCGCGCGAGGATATCCTCGTCTACGGCGATATATGTAAACTCGTAGGGGTGTACGCGGCGAAATTGAAAAGTTTTTCCATTTTCGAGATTGTAATAATTTACAAAACCATCGATATAACCCAAACCATAACGGCCGTCTTCCACTTTGGCGAAAACTAGACAAAACTTTTCCTCAAAACTCACTCCAATGTGCGTTTCCGAAAAATGGCATAGTACACCTGGAGTTCCTTCTTCAAGAACAATTTCGTCAATAAAACTTCCCGATTCTTCCTCTAAAGAACTCTCCACATCGCGCTTTACGCGTTTCACTTCGCGCTGTAAAATGATGTCGTCACCTTCTGTGTAAAACTGCAAACCTTTGATTTCGCTATCTGTCAATTTATAACTTTCAACAACACCATCGGTATAAGGTATTAAACTCGAACACCCCATACACAAACAACATAAACTAAAAATAAGATATTTCATACCACCCTCTAATTTCCAAGAGCTTTTTGAACTTCTTCTGTAATCAGGTCTCTCACTTTTTGCTCCACTTGATTTGCTGCTGGCTGAGTAACTTCTTTTACTTTAGCTGCAACAGGTTCCAGCAGACTACTACCACCACCATCTCCCTTAGGAGCAGCAGCCCCTTCGCTTCCTTTGGTTTGACCTTTTTCCTGCGGATTGACCAAAACAAAGCTCCGCGCTTTCTTTTGCTGTGGCGTTTGTGGTGCTTTTTTCTTTTTCGTTGGTGTCGGTGTATTTTCGTCCCCTGTCGAACCTACGGTGTATTCAGGATACGCAATCTCTTCTCCTTGAGGAATATCGAAAAAAGCATCCATGTCGATTTCCACCACCGGCTTTTGCTGATAATTTTTTTTATTCTCTGCAACCACTTTGCGTTGTTCATCCGAAGTAACGCTGTCTTCATATTTCTTTAAGACTTGTAGTATCCCACCGCTGTAGCACATCAAATTATGAATTACCGACAGTTCAAACAACTGTTGATCGTCCTCAGGGGTTGTCAATCCGGTAACCGGAAGAATCTCAGCCATACCAAGATACAAATCTTGACGTTCCTTTTTCGTCATGGTTTCCGCCATAATTTTGTCGAGATGAGAGAGATGCCTCTTCATCGTACTCGTATTAATGTAACGGTTCACAATTTGATTCGCATGTAAATCTAACATATAGTGACGTTGTGCATATTTAATGATCTCACTCGCGCATATTTGAAATTGTTCATTCAACGCCATTTTCTTGACCAACAGTACAAACTTCACTCGTGTCTTGTTATCGATAAAACTACACGCCTCGGCATCATACGTTACTTTTTCCGTTTGTTGCGGTGGTTCGTTAACTTCTGTACTAGAAAAACAGCCGGTAAGTACAAGAAAACATATCCAAAATACATATCTCATTCTTCTTCCTCACTCTCCGAATTACTTAAGTCAACCGTGTTATGCCACGGAATCATCTCTGGTTCTTGAGATGTAGTGGATTGCCAATCATTTTTTTCATAGTCTTCTCTCTCCGTACCAGAATCTCCATCTGACTTATCTTCCGTCGTTGACGTTGATGATGTCACTTCATTCGTTGATTTTGGCACTTCATCTATAAAAGAGTTGCTTAGGTCGATTACGCCCTTCTCGTTCTCTTTGAATTCAGGCATAACAGGTTCTTTCACTTTTACCGCGTCAGGTTCTCCAGGTATAGGTTCCCAAGTGCTTTGCGAATTCCTCTCCATTTCAGAGTCATTATCGGTCATCAGCGGTGCTTTGTCTACAGCAGAATTCTCATCTATTTCTTTCTGTTCTACTGGTGGAGTCACTTCTTTTTTGGGGTTCTCGTAACGATTGGTTTTTGATTTAATGTAAGCATACATCTCGATTTGTTTTGGCTTTGCTAGCAAATGTAAATCTCCACGATCCGAGCTTGATGTCTTATAACGGTCTAACGCTGCCACAAGCCCTTCCGCAAAACACAAAAAAGATTTGACCTGATGCGGCTTATATAGCTCGTCTTCGTACCAAAGTACAGAATACTCCAGCATGGAAAATGTCTGTGATAGTTCGCGATAAATGCGCATTCTTTCTGTAATGGTCAATGTCCGCGACAAAAAGCCATCGAGATAAGAAAGATAATTTCGCAAAACCTCTACAGTCACTTCGCGATTCTCTTCTTTGTTTTTGCTTAAAAGATGGACAAAATTTTGCTGTAAATACTTTTTTAAATACGGAGAAAATGCAATAAAAGAATCGTTGATATCGAGGTGATTCACTGCTAAAGCCAAACGAACTTTGATTTCGTTATGCACTCGCTCACATCTTGCAAAACTAAAAGAAGGCTTTTCTTCCACCACTTTTTTGCGCGGCGGTGTTGATTTACAAGAACATACTAGTAGAATAGAAATATATATTATAAATTTTTTCATTACCTTTCCGTTCTTTGGAGTTGCTATGAATTATTTTGCTTTTGTAATCGCGCTATTCTTTGTTGGGTGTTCATCCAACCTAATGGTACTCAATAAAGAATTAATTGATAAATTTAACTTATCGGAAGAAAATTTAAAATCTCTACAAGTTTACGTCTCCGAAGATGTAGAAATGCGCAAAATAGAGGACAATGATTCTATTGTAAAAGATGGACAAATAACGCCCAACGCGCAAAAAGATATCCAAGACGTCATCATCGAAGAAATGACACCGGGTGTTATACTCATTGTAGATGAAGATATATTGGCCGTTAGTTTTCAAAAAGGGTCTGCGCTTATTTTTTCGGATCAGGATGCCGCTTATATCATTTCGACAAACGATGGAAAAGTCAACTTCAATGGTTCAGAATATCTTTTGGTAGACGGCTTTGATGCCTTTCTTTACGTCGATGCTAACTTTGAAGAAGTATCTGAAAAAACCCAAACAATCACCGGACAACCCATTGATGAATAGAACGTATTCCGTTCCTTTTGCCAATAGAAAGACTTACAAAATTGTGTCATTCCCGCGTAAGCGTATGTCAAGCTGAGAATAAAAGCTTTCTCAATAAAGACTTGCAAAACAGTGTCATTCCTGGCTTGACCAGGGATGACACCCTAATTTTAGAGTGCTTTACTTCTTAACTTTAACATATGTACTTTCGCAAACCGTACTCAACTTTTCGCCATAGGCCAAACTATTTTTTGACAAGCGTGTCGGTGGTTTTTACAACCTCAACATCGAGATGTGGAACATCGGAACGTACCGCTTTTACTTCCCAGTAAAAACGCTGGCGTTTATTGTTATCATCAATCGCTGTTACCGAAAACTGACCATTGCGAACCGCAGAGGCAGCCAAGGCAGAAGTTTTATTTTCTCCAGGGTCACACTTAGGTGTAATAAGAACTGTGCGATTTTCCGCATGAGTAAGCGCTTCAAAGTATTCAGGAAGAACAATCGTTGTTTTTCCATTGATGAGTTGCGATTCACCACGGTAATATACACCTATTTCAGGTCCTTCGAGTGTAGAGTGCTGTAAATCCTTTTCATGGTTTGTCGGGTGATCAATGACAAATTGCTTGGTTTTGGCGTTTAGTTTACCAAGAACACGTAAATCTTTTTCGACAATCAAATGCCCGCCTAGGTTATTTGCTCCAGGATTGTCCGTCTTTATATACACTCCACTATTCGATATTAAAGATATATCTTTCCCTGCCGACACAATCATACCATCGGGGGTAGATAAAATTTCTTGAAATTCAACATCCCCTGCTATTTGCAATTTACGCCCTGGATAACGATTACTTGGAAGCGGCTTATTTGGTTTTATGCGCGGGTGTATCACACTATTAAAAATCGCATGATCATCTTCATCATTTCCAAAAATTGCGGTACCCGTCACTTTTAAATTTTTTGTCAACAGGCGGCCTGCAAACTCCGCCCATGGTGCATCAAAAAATAATCCACTTTCTTCTTTTTCGTAAAGTTTTCCGTATATACTTAATTTTTCACCTGTTTCAGAAGTGACCGCCAATCCACTACTGCGACGTCCAGAACCATCAATTTTTATTCCGTCTGACTTCACAATAACTTTCGCGAGTACAACGTGAGAATCTCGATCAGGAGAAGACACTAAATCCACTTTTCCCGTTTCGATAATACGGCTATACCCCTTAATTCCCGCTTCCTCTACTGGCTCTGCCATTTTTTCATCGTACATAACAACAACATGAAATTTATTTGAAGGAAACTCACTGTCTTCGATATTTAGAGTTTTACTCAGAGATATAAAATCACCATTGGCAGAAATAGCATTACCTGCTTCTATCGAAATTGTCTGACGAACTGCATTCACCCTTAAACCATTTATAATTCCCCAAGTGTGCAAATAGCGATGATGCATACGCATCATTTCTACATGATACTCTTGTTCATCTTTAAAATCTTTAACTCTAAGCAATTGGCCTTTGAAGAAATTGACTCTTTGTGGTGACATTTTAATTCCTTTGCATTGATCAAACTCACCAACGTATATCGTTGGTAGTAAATTTACTTTCCAAGAATAGTATCTACACCTATACGACTATGTTTTTCAACATCAATTGTCGGCATATCTATGTGTAACTTGTAATTCGTATGCGCAGGTTTTTCCGTCTCGATAATCTCGATAAGCGATTTTATTGTCATGCGCAACTCGTGAACAGGCATGCGTTTTAAGGTAACGTAAACATCAAAAAAGTATGGAGCTCCTTCTAGAGTAAACGCTCCCCCAACAACTGTATTTTCTCCCAAGTACATAGGTTTAATAGACTCGGTAATGCGAATCTTTTCACCAATGTAAATAGACAAGTATTTCTCTAAACCTATCTTAGTACCTCGCATGCGGTATAAAGGTATAATTTCAGCAATTACTTGTCTTTTTTTATGAATCGACCACTGTTTTCGAAGTGTCAAAGAAACCGCTCCCGCAAACCAAAATAAAAACTCTTCCAACCAATCATCAAAAGATTTATTGGGTGTAAAGTATCTATTGAGTTTTTGTAAATCACGATTATCTAATTCAGGAATAAATTCGGTATTTACTTTCGAAAATAAAAATGAAAAACGCGGATGAAAAAAATCGGCAATGACATCCAGAAGCTCTTCGATCCCTTTACGTCCAGACAAATAGACGACAAATTCATCATCACCACGATGAATTAAATACGTATGATCGTGGTCGTGTAGACTCCACTTCTTTTTGGGTGTTAAAGTAACAAGACGCGCATTTCGCGTAAGGTCATGCCCCGCTTGTTTAAATTCTTTACGTAATTTTTGATTCACCTCACCATTTCTTATATCTTTTCGAAAAGACAGAGGTATCGAAAAAACGTAATCAAAAAGCTTGTCGTCATCTACTTCTCCCCATATTCGTTCGAATATTTTCAAATACGAATCGAAGAATGGTGGAAGATCCTTATCAGGTGTTTCCCGAAAAATACGTGGTAAAAAATTTAAATAGGAGCTTTCTTTTCGCGAACCGTTGTCTTTCATCGATTTAGTCTCCTATATAAACTACCTGAATGTCCATTTTTTCAATTCGAATCAAACCTTTTACCGGCTTCTCTACCAATTCATCATCGATGTAAATATGGTGAATACCACTTACGTATTCTTCTTTTGAAATAATCTCCGTTAACTCATAAATATTGATCGGTTTTTTGTATGGCCAACCACTACCATCGTGGTAGCCACGTATAGGATCAACATAATCGAGTATCTTTTTCTTGACATTTTTCACCACCGCGTTTTCTGGTACGTGAAAAGGTATCATAATTTTTGCCACAATATTAATGGAAGTGTAATCAGCCTTCTTCACTTCCAACCATGTTCCCAATAATTTTCGTTCGCTTAAATACTTATCGACAACAGGTAGCAACTCTTTATACGAATTTTCTTCATCAGCAATAACAATAACTTCGATTTTTCCCAAGTCTTTACGCTCATTTACGATAGCACGTCGTACTTTACTTAGTGAACGATTCTCTGTCGATTTAATGGCCAGAAGTTCAAAGTCCTCCTTCGTCACTGCGCGGTATCGCGAATTGGCAAATCGCGATATTGCCTGACGAATTTGTCCTAAATCAACTTTTTTTCCCTGTTTGAAAACATCCAACATCAGATTTTCATAGCGAATCAAATACTGGTCTTTGTCTTTGATAATCCACTCGTCGTCTGAGTTTATCTGAGCCTCTGCATAAGGAGAAATTTCAATGCTCTCTGCCGCAAAAGCTTTACGAATCGTCTCCGATAAGTCCGCTTTAGATAAGTATTCGACAATCTCCTCGACGTCTTCTGTTATGCTAAACACAAAGTAGTCTTCCAGTTCTCTTAAAAACTCTAAAAGCTCTCGGTACTCCAAATCCAAATCTTTTTGCGATAACACATCGTCAATTTGATTTCCCGTAGCTCCCGCCACCAAACGCAAAAAATTCAGATATGCTTTTTCTGGTATATGGTTGACGCGATAAAGTAAGTGTTCTCCCAGCCAGCTAAGTAGTTCAATAACTGTTATACCTGGATCAGAAGCATTATAATTCGTCCACTCACTGTTGTATTTTTTTATGGACGAAATCATTTCTTCGCGCAACTCATCGTAATTTTTTTTATGTAAATTCGGAACAGGTAATGACATGTTTCATCTTCCATTTTTACGCAGTAATATTTATTTGAATATTCCCAGCAATAGGCAGAGCATCGGCTTCTAGTGTAATCCACCCTTGATTTGAACCGTAGGCAGTTTCCGCAACTACACCTTCTTGCACTTTTTCAACCGTAATTTTTTTAATTGATACAACATTCTCCACACTGTTCAAAATTCGAACAACATCCGCAATCAAAATCCGTGAACCAAATTCCCAACCTTTTTGATCTCTTCCACCTTTTGTCGGGTGTAAGAAGTTACTGAGAAAGCGCAAACATTTTTCTTCTACCTGTGCAATTTCCGTCACAGAAGTAGGTACGATTTCGGTAATAATATTCACTTTTTGGTATCGCGGACCAATAACGCGAATTCCTTCGGTAATGGTAAGAAGTGCGCGTTTTTGTAAATACTCACGTACATTATCTAAAAGCGCTTTTTTAGGATAAATTTCACTTTCATCACTTGGCACAATGGCAATGGTCACTTCTCCACGATTGCTATCGATATATTTGGCTTTGGCCACTTCTTGAGAAGCCATCAGAGCCAACCACTCATAGTCCTCTTTGGTAACAACGCGGTCTTTACTCTTTATCGTTTGTGGCCCACGTTTTACAGCATCGTCTAAGCTTTCCTGGTCGTTGCCTCCCAAAGCAACAGCATAGTTATTCACACTATCAATATTCGCAATATTAATTGTCAACGATGAAACTGTACCGATCGAAACATTTCCACTTCTACCGCCACCACTCGAATATATTTTTGCCACAATATTGTCTTTACCCGCAGAAGGGATCATTCCTTTAAGCCCGTCACCAAATGTAATCGTACCATCTTGGCGATTTAACGTATAATGACGACTAAAAGGTGTTGACCCCGAGAAGTCGAGTACTTCATGCCATCGCACCCAAGTTTTTCCTTCTTTTGTAAAGATGGCATCTTGCCCTTCTTCAGCAAATAATAACTCGCGCTCTTCATTTGGCACAAGTTTCGACTCATGAACGATCAGTTGTTGGTTTTTTAGTATGGGCGTTTGTGTCAATTGAAATTTCAAATTTGGCGTGTGGTTACTCGAACCTAAAATTTCATTGGTAATCGTTACGCTATTTTTTGCCCATACAGAATTAAAATGTATTCCTTTGAGAGATGGACTAACCACTTTGTCTCCCTCAATTTCCACCTTAATCCAGTAAAGACTTTTACCAAACTTATGCATTGGCTGAATATTTTTTGGAATAAAAAATTTGGTGATTTCTCCGCTCCCAAAAAAACTATCGCCGTTTTCGACTTCTAATGTTTTCCAAGTCGTACCATCAAAATATTTCCAAGTTACCGCGGCACTTGCTATTCCATTTTTCTTTGAAGTACTTTTTACTAGTGTACGTATATCTTTATCATTATAGATTTCTCGCATCGCAAAGTATAGAGTATAAGCGATTCCTCCCACATTTTTATTAAAACCAAAATACAGTGATGGATTTTCTCCGATTACTGGGCGATACGGATAAAACGTTTTTTGTTGGTCGTGTATAAAATACTCAAAGTTGCTGTGGCTTTGGATATGCGAGAACTCTTTTTCGCGAAATGTGATATCCATAACCACATTTTCAATAAAAGGTGGGGTATACTCCGGTGTCTGATAACGAACACCTCCGGTAATGCCCTCTTTAATCAAAATATTGGCAATGTCGTCCCAGCCGTCGAGTATTTCGAGAATATTTCTTGTCTTCAAATATTTACCGGGAATACCATATGTTCCACTGCTAATACGAGCACGAATCCAATAGTGCTTCACGCCATTGATTTCGACAGACTTCATTGCCGGACAAACAAAAGTAATGCGTCCACTCTTCGTAAGTCCTTGTGTATCGTCTTGAAACTCGAAACTCTTTGCTTTTTTACTTTTTTCAACCGCTAAAAACTCGTCTTCCACTTCATTTTCGTCTTCACGTGCGTCTTCTTCATCTTCGACTTCACGTTTGTCCGCCACTTCAAATTCATCCTCAACTTCGCGTTCGTCTTTAGGGTCTTTCTCTTTGTCTACCGTTTCTTTTTCCTCAAGACTTAACCACCGCTCACCGTTCCAATATTCCCAAGATAACTCGACTTCGACATGCTTTTGCAGTTCCGTGTGAAATATGTCTTCGAGTAATAGTCGATTTATATGCTTAACGTCGCGTTCTTCGACATCGCTGCTGTAAACATAATAGCGCGCTTCCTCTCTTAGAACAACGTCTTTAAAGGCCTTCTTGTCGTACAACAGTCCTTCGCTATCAATCATCGCGTTGAGTGCCTCGAGTACTTTCTCTGACACTTGGTCTGGTTCTTCCGCTTTGTCAATTTCTCCTTTTAACTCTGCGGAAAACTTCGTTTGCAAGTGTTTCGAAATTCGACTATTGCTGATAAGTCGTCTTTTCAGCAAAAATAAATCTTTAATGTCGCTTTTGGCCACAGTATAGCTTGTAGGATTAATGTGAGGTAGATCTTCTTGTAGATTAATATTCATGCTAATTTGCGCACCGGTTTTAGCAAAATTATGCGACGCAATATAGCATGTATCTAACTTCTTTGGAGTTTCGCCAAAAGGATAAAACCCCTTCTCGATTTCCACGGAACTGTCATTGGCAATTGCGGAATCTAAAAGTAAATTGCTCACCTTTAAATCAGCGCTTACTCTGCTAATTTTTGGAAGTATCACCTCTTCAGAAATTTTTACTTCTGTAAAATCAGGCTCGACCGACAACCAATAATCTTCGATACCATTTACCACAGATTTTTCCAGTGGGCCAATCCCTTCAAATGTGAGTTCAAACTCTTCTTCGCCTACCTTGTTTTTCGGTTCGTAAACTTTTCCTGTGCTATCTTTCCAAATCGAAAAATAGGGAAGAAAATTCTTCGCCGACCCGATAATTTTAATTTTAATATCGACGGGTTTTTCACTAGAAAAAATCATAGAATCCCCCAAATACATCTTGTGGGGAATATATTGTTCTTTGTCGTCCTTACCAAAAATGTAAAAACCTTGCTGCTGCTCTTCCAAAATCAAAGGATGATTCGTAAACTGACCAAACCACGGATTAAGCGACACAATCTGCTGTAGTGGCGTGTGAAACACCGAGAGACCTTCCTGAGTTTCAAAAATAACATCGCCATTTTCCGACGACGCCACCTGTGTACGAAATGGTACATAAGTGCTTGTGGCCCCCTCGGCAATGGTAAAACTCAAAGGTACTTTTGCTGGCTCTGCAGGTAACGGATAGACGCCCATCAAATCTAAAAAAGCAACTAGGTATTTGTAAGGAAGAATATTCAGTTGCTCAATGATCGTTTCCGACAACTCCGAAAATAACTTCAACACCACAACGCGAAAATCTTTGGTATTTATTTCGTTTACATTTTCCGGCCAATCTTTTGTCCATTCAGGACAATATTCCCGAGCTAACTCGACGGTATGCTTGAAAATATCCTCTGCAGTTCTATGATCAAGATGAAAATGCATCATTGCTCCTCTGCGTCAGGTAAAATTTCTTCTAAAACTTGAATGGCACCACTTATGCGCAACATCATCTGTTGCAGGTCCTTACGTTTTTGTTCTAGCTCTTGTTGTTTTGCATCTAGTTGTACTAACATTTTTTGGCCGGCATCCCACTCTTCGCGCAGCTCTTTTAACTTTGTATATGCTTCTTTTGCAAATGTGTCCATTTTGTTAACCACTTATATAAAAAGGATAGACCAAGTTTCTTTGTGTATTGGTATCAATTACAGTGTAATCGATTGAAATATTTATGCGGCTATCTTGATCTGGATCAGGGGTTGCTTTTACTTTGATATTACCAATACGCGGCTCCCACTCTTCCAAGGCCTCACGAACATAACGCTCCGCAGTGTGATATGTTCTCTTATTTTTCAATTCAAAAATAATCTTGTGTATATCACAGCCAAAACGCGGACGCATCACCCGTTCGCCCTTCATCGTTCCAATGATAATAAGAATAGATTGTGCAATACTATCTTCCCCTCCGGCTTCCGACTTTTTCGTCCGCTCGGTCATCGGGTACTTCCAACCTTTTCCTAAGAAGTCATGATCTTCTGCCACTTTTTCTCTCCACTATACAGCGCCCTAATTTAAGTTTACCGTACTTCCTTTAACATTAGTAGTACTTCCTTTAATATTCGTCGTGTTGCCTTCGAAGTTGGCAGTTCCCGAGGCTTTGGCATCAAGGCCTCCAGAAGATTCGATTTTTATACTACTCGAACCTTTAATTTCCACATCACTTGCATCCAAAGCAATCTTGCCGTTTTTGGCCGTCATGGTAATGTCCGCATCGCTTACAATGGAAATAGTGTTGGTACTTGAATCGATGGTGATTAGATTTTTTGTCGTTTTGTCGATAATCTCAATTTTTTCCGAACCGTCGGTGTTGTCAAATTTAAGGGTATGCCCGCTACGCGTCTTAATAACAGAGAAATTATTCTTACCATCAGCGTTGTCTTCCACGGGCTTATTGACACCATTCCACAACGAACCAATCACAAACGGCATGTTGATGTCTCCATTTTCAAATGCCACCAAAACTTCGTCTTTGACCTCCGGTAGGAAAAAAGATCCAAACTCTGCTCCCGTAAATAGCGTCGCGATACGAATCCAATCCGTCTCGTTGTCTTTACTAATTTTTGGAAATCTAACTTTTACTCTACCGAGTTTATCGGGGTCCTTGTTATTGGTAACCACACCAATAAATACTCCTGTTACCCGCGACTGATTTTCACTTTGATAAAACATATCGACAAAACTCATATTCCCGTCTTTCTCACTTTAAATTTGGTCGTGTATTGTTTTTTGTTGAGAACGTGCGTTGTACCTGTTACATAGTAACTCCCACTAAATTTATCTCCCAAGTTGGTAATTTCAATGGTTGTTCCAACGCGTATTTGCTCTGTACCTGAATACGTCCCTTCACCTGTAATAAAGTCTTGTTGCGTTTCATTGTAAAAGGCAGCAGCACGTGTGTCCGCTTCGCTTTTATCTACAAAATTTTCATTGACAATGGTATTTTCAGCACTCTTAAACGCAGAAGTGGCCATAGCATGCCCCGTTTGGCTTCCCCCCATTTTACTTATTTCATCTCCCGCTTTTCCACTACCGAGAATTTCTTCCATCTTTGTCACGTCCCAACCGCGTGTCTCGACAACAGCCCCTTGTCGCACCGTCCGCAAACTTACATTAAAATCGAATATATCTTCTCCAAAATTTAAACTAATGGACGCCGACTTATCCTCTTGGGATTTGCGAAACAGTAACTTTTTATCATCCACCATTAACTCGTAACCAATTTTACGCGCACGCTCCAAAAGAAAATGGTAGTTCGTTTGGTTAAACTGAAACAAACACGGGTATACCGTTGTTGTGGCATCTGCTGTGGCGGAAAGCCCCTCTTCACTTGCAATTGTTGAGACAATTTGACTGTCTTTTTGTTCGGCAAAAGAACGATTCTTACGGCCAAATTGCAAACGATGCAGACGATCAAATCCACGAACTTCAATATAAGGAACCGATGAAAAAGAAATATCAACGGCGGTAATTTCGCCTTTGAATAATTCTTTTTCCGTATCAAGTCCCATAGAAATGGTCACCGCTTTCCCCGGAGCAAATTTAGAAAGGTCTACATTTTTCCATGGTCCACTTTCATCGTCAATAATCGACAAATAGAAGTAGAACATCGTGGGAAGATTCAATTCTTCTTCCACAACCACCTCAATCAATTTTGCCATCTTACATTCGTCGGCTTCAGAATTATCAATCAAAATTTTCGCTATTGGTTTTCCCATTTTTTATCTCTACGTAGGTAAGTCCGGTAAAATCAACACTCTACCAATGTCATTCGGTGTTGGAAATTTAATAGGGTTATCGATATCATTTTCTCGGGCAATAAATAGCCACTGTTTCGCATCCTGGTAAATGGCGTTAGCTATTAAATCCAAACGGTCATTTCCTTTAACAATCCATGTCTTACGGCAACCTTCGAAACCAGAGTACTTATTTTTGTCTTTCTCGGGAATAATCGCTTTGAAATTAAGAGACAATTCTGCACGAAGTGGCTTCCCATCACTATCAAACATGGTATACTTTGCCTCGGCCTCCGTAATATAGCCGAGGTAGTAAAACTCTTCCCAATTGAAGGAACATTCTGGACGACGACGAACACTACCACTCGACTGGGTTGGCAAAGTGAGTTCCTGAATCTTCATCATCTCAGAACGAATGTCAATACTTGACGTATACGCGTGATATTGTAAGGTAATGTCCAGGTCACCTATTCCCGTACTGTGAAACGGCAAATCCACAGATTCACTACTCGCCGTAACATCTCCACCAGTAACCGTGAGTACGTCTTCGTCTTTTTCGTTACCCTCTTTGTCATCCGCGCTTAATTTATAACTATATCCTTCAGGGTTAAACATAACCGTAAACTCTTCCCCTGTATCTTCATTTTTGATAAAGGCGCGCTGGCTATTTGTTACGCGATAATCTACTTCTGACGGGAAGAAAGGATTTAGGCTTACCATTAGAAAATTCCTCTTCTATTTTTTTCGATTGACATTTTTTTCTCCAATATCTTGTACACTCGTGTTGCAATACTGTTAATTTTGGTATCACTCACGTGAATATGTGTTGTCCTTTGATTTTTTTGCGGCTTTTTCTTTTCCTCAATGATTTGCTTCTGTGGGTTCTCTTTGTATTTTAATGGTAATTGTTCACGCTGCACAGCAATATATTTTGGTATAGTTTCACGACGTTTATACTGTAAACGCTGATGCGATGACGATGTATTCAAAGGTTTTACTTCAGATTCGTGGTTTACATATATTCGATGAGACAGAGGATTGTTTGCCGTAAAAAAATACTTATTGTGGAGCTGTGTAAATTGATTTGCCACACGGTCTCTTAAGCTCACAAGTCTTTCTGAGAGCATCTTACTGTTTGTAGGATAATATGCATGGTTGTCCGTTTGTGGCGTTTTATATGTAAAGTGGTTCAAGGCATACAACATATTTGGGGTTGCACTTCTGCGTTGCAATACAGTATTGCCTTGTTTAGGAATCATGTGAGATATGTTACTTAGCACCTGTAATAGTTTATTTTGATGGCTACCTTGTCGCGAAATTTCCGGTGTATTTTCCATGTGTTGCTGATACGTCAAATGATTGCCGACATGTAACATATTGCGCATGCTGGCATTTTTGCGCGGCAACATCGTATACGTCACATTACGTGTATGATTCGCAGGCAGCATGTACGCTAGATGATTGAGCATTTGTAATAAGCTATTTGTACTCGTTCGCGTCACATTTCTATTTTGTGGTGACGCGTTGTTTATTTCTTCTACGTATTGCTGTGGTGTACTATACGTCAGATTATTCACCACTTGCAGCATCTTGCGCATATTCGTACTTTTGCGCTGCAACGTCGTGTATGTTGCGTTATTTACATTCTCCGCGGGCAACATATACGCGAGATGATTGAGCACTTGTAGTAAGTTATTTGTACTCGTTCGCGTCACATTTCTATTTTGTGATGACACATTGTTTATTTCTTCTATATATTGTTGTGGTGTACTGTATGTCAGGTTATTCAACACTTGCAACATCTTTGGCATATTCGTACTTTTGCGCTGCAACGTCGTATAAGCCGCATTATTCGTGTGACCCCCCGGCAATGTATACGCCAGGTCGTTGAGCACTTGTAGTAAGCTACTGGTACTCGTTCGCGTCACATCTCTATTTTGTGGCGACGCGTTGTTTATTTCTTCTATGTACTGCTGTGGTGTACTGTACGTCAGGTTATTCACTACCTGCAACATCTTGCGCATATTCGTACTTTTGCGCTGTAATGTCGTGTATGTTGCGTTATTTACATTCTCCGCGGGCAACATATACGCCAGATGATTGAGTGCTTGTAGTAATTTATTGGTGCTCGTTTGCGTTACATTTCTATTTTGTGGCGACGCGTTATTTATTTTTTCTATGTATTGTTGCCGCGTACTGTATGTCAGGTTATTCATCACTTGCAGCATCTTGCGCATATTCGTACTTTTGCGCTGTAACGTCGTGTATGTTGCGTTATTTATATTCTCCGCGGGCAACATATACGCCAGATGATTAAGTACTTGTAATAAGCTATTGGTGCTCGTTTGCGTCACATTTCTATTTTGTGGCGACGCGTTGTTTATTTCTTCTATGTATTGTTGCGGCGTACTGTATGTCAGGTTATTCACCACTTGCAGCATCTTGCGCATATTTGTGCTTTTGCGCTGTAACGTCGTGTATGTTGCGTTATTTATATTCTCCGCGGGCAACATATACGCTAGATGATTAAGTACTTGTAATAAGCTATTGTTACTCGTTTGCGTCACATTTTGTGGCGACGCGTTGTTTATTTCTTCTATATATTGTTGTGGTGTACTGTATGTCAGGTTATTCAACACTTGCAACATCTTGGGCATATTCGTACTTTTGCGCTGCAACGTCGTATAAGCCGCATTATTCGTGTGCCCCCCCGGCAATGTATACGCCAGGTCGTTGAGCACTTGTAGTAAGCTACTGGTACTCGTTCGCGTCACATCTCTATTTTGTGGCGACGCGTTGTTTATTTCTTCTATGTACTGCTGTGGTGTACTGTATGTCAGGTTATTCACTACCTGTAACATCTTGCGCATATTCGTACTTTTACGCTGCAACGTCGTGTATGTTGCGCTATTTACATTGTCCGCGGGCAACATATACGCTAGATGATTGAGCACTTGTAGTAGGCTATTGGTACTCGTTCGTGCCACATTTCTACTTTGAGGCGATGCGTTACTTACTTCTTCTACGTATTGTTGTGGTATACTATATGTCAGGTTATTCACCACTTGCAGCATCTTGCGCATATTCGTACTTTTGCGCTGTAACGTCGTGTATGCCACATTATTCGTGTGTCCCGCTGGCAACGTATACGCCAGATCGTTGAGTACTTGTAGTAAACTATTGGTACTCGTTCGCGTCACACTTCTATTTTGTGGCGACGCATTGTTTATTTCTTCTATGTATTGTTGTGGCTTACTGTACGTCAGGTCATTCACCACTTGCAGCATCTTGCACATATTTGTAGTTTTGCGCTGCAAGATCGTGTATGTTGCGTTACTTACGTTCTCCGCGGGCAACATATACGCCAGATGATTGAGCACTTGTAGTAGGCTATTGGTACTCGTTTGCGTCACATTTCTATTTTGTGGCGACGCATTGTTTATTTCTTCTATATATTGTTGTGGTGTACTGTATGTCAGATTATTCAGCACTTTCAGCATCTTGCGCATATTTGTGCTTTTGCGCTGCAACGTTGTGTATGCCACGTTATTTGCATAAGCCCCGGGCAACGTATACGTTAGATGATTGAGGACTTGTAGTAAACTATTGGTGTTCGTTTGCGTCACATTTCTATTTTGTGGCGACGTGTTACTTATTTCTTCTACGTATTGTTGTGGCGTACTGTATGTCAAGTTATTCAACACTTGCAGCATCTTGCGCATATTCGTACTTTTGCGCTGTAACGCGATGTATGTTGCATTGTTTACAGTCTCCGCGGGCAACATATACGCTAGATGATTGAGTACTTGCGATAAACTATTGGTACTCGTTCGCGCCACATTTCTCGTTTGCGACGTATTGTCTACTTCTTCGACATATTGTTGTGGCGTGTTATATGTTAAGTGATTCACCACTTGCAGCATCTTGCGCGTATTCGCGCTTTTACGCTGCAATATTCTATATGCCGCGTTATTCACATTTCCCTGGCGATTATTCACCACCTGTAACATACTACTTTTACGTTGTGTGGTGGCCTCTACAAGATGAGTATTTTGCGAATTTTTATACAAGTACTTGTATTGTTTTTGTGAAGTTTTAGAAAACATATTTTGCTGAACATTTTCGTTAAAAAACTTCATGTGCTGCGCAATTTTCTGTGTATGTTTTTGTATATTTTGGAGAGAATAAAGAGGAAAGAACGAATGCAAATTCGTTTTATCTTCGAGATTTGTTTGTAAAATGCGCTCGAAGTGTTTGAGAAAAAAGTTTATATTGTGTATATTTGTGGTGGTAGACGTTTCTTCCGTTTCCTCGGGTTCTACCATTGGATTTTCTTGAAAGACAAGTGGAAAAATTTCCGTTCTCATCATCGGCGCACGATATTTTTCCCAAATTTTGACATTGAGATTTTCTCTATGCAGATGCTGAGTAATCAAATTTTGTGGTTTAATGTACTTAATAGCGTTCATTATGACGTGGCGAGGGAACTCACAAGTGAATTAACGCGAACCACAAAGTTATAGACCTCGCACTTCCTTTCTCCCGTTGTGTAGCTAAAAAGTAATGGACAATGAAAATTTTCACTCGCGAAGAAACATTCCTACAAAATCTGTTTAAAACCGTGATGAGCCATGGTGATCTCTTCAAACACAATTTCTCCGTCTGTCGAATTTAGGTCACTGACAGACCATTTCGTGGGAAAAGCATTTAGAAACATCCATGTTTTCGTCGGAAGCGGAATGGGACCAGGTATATTTTCTAAAAGGTGCACAATAATATCTACACGCCCCGTTTTTCCCTCGGCAACGTCTTTGACCCACGAATAAAAAGGGATCAAGCCTAATCCACGCTTCAAAGTCAAATCGCTGTAACTTACACCCGTACGAATGGTGTAGGGGAAAGGACACCCTCCTTCACTAATTGTTTCCGTCTCAATACTTACTTCTAAACCAGAAATTTCAGCAAATCCCGCAATGGGTAAACCATTGATTTCTACCATAAAACGATGATTTAAAAAAAGTAGATCTGGAGTAGATCCAAATGCCGCTGTTCGAATATCTACCATAATAATCCTTACTTTATACTAAAAATACTTTGGGTCTTTGGCTTTTTTTCGTTGCTATTGAGCTTATCGTTAATGCTGTTGATTTGTTGACACCACTTTTGTCTCTCTTTGTGTTCCATATTCATAATGGTTTGCCGTGCCCAATGAAAATGGAATGCGATAAATGCTATCTCTTCATAGAGACGTTCCAAAGGATAGCGAGCTACTCCCCCAATGAAGGCACCTCAACTTTAATTCTTGCATTACAATTTGGACACTTCGTACGAAACGCATCTTCGCCATGCTCATTAAGTCGGTTGTACAAGTCTTGCAAATACGCAAAATCTTTAGTAAATAAATTTTCGATTATATCGGTGTTAATTTCTTCAATACTACCAAGACGAACGATCACTCTGGAAAGTAAAGCAATTGGTAAATACGAGGGATTGCTTTTTACTTTAGCATCTTTGGTTGGAAATATTTCGTCTGCAGCCGTCGCTAATCTCATAATACCATTTTTATGAACGACTCCCTGGCTATCAACATAGCCCATAGGCAGCGAAAATTCAAATTGTGTCGCAATATCCATCTTTAGGCTTCCACAAATAGCTGATTAAAATTCGTTCATGTAGAACATATACTAGCGCAAAAAACATACATCTATAACTTTGTCTTCAAATGTGTTCTATGATTTTACATTGTAAGCTGTGGTTATAGATGTACGCTTTAAACACTCTAATTTTCTGAATTATCTTCTACACCATTAATTTGGCTATACATTCTTTGTAAGTAGTTGAAGTCTTTGGTGAATAAATTTTCCACAGTTCTTGGCGTCACCATTTTTAGGGTGCCAAGTTTGACAACTACTCTAGATAAGATAATAATGCTCAAATAGGATGGATTTTGCTGAACTCGTGGATCGCGCATCGGTAAAACTTCGTCCGCTGCTGTGGCAAGGCGCATTTTTCCGACCTTATGCAAATTGCCGTCTTCGTCTACATAGCCCAAAGGTAATTCAAAATCGTGTTCTATTTGTAAAACGGTCATGTATCATTTCCTTATGTTACGCGTTTTACACCTTCGTGTTGAATCGTAACAGTTTCAGGTATAGGTTCGTCGTTTGTCGAATCCAATTCGCCATACTCAATCTTCGAAGGCCAACAATTTACAATTTCCCAAGAAGGGCCATCGTTACCTTCTTCATCAACTACAGTAATTGACATATTTTTACGGTTGGGGATTGCGCCTGTTGTGATTACAGAATTATACCATTCCCACAATTCCAAACTACTGAACAAACCTTTTTCCAGTGTAATTTCAGGATAGGAGGTGATACCGGCCAATTTACTTGTGGTAACATTGCCACCTTCCGCATATTCTTTTACTTGCGTTTCCGGACTTGGAATAGCAATTCTTTTAAAAGACGCTATACCAATACCGTCAATATCAACGCGAAAACGATATCCGAGATATGGATCGAGATGGTCTCTTCTATCTGCCATAATGAATCACTCCTTTATCTATGATTGCGGGGATTTTTGAGTAATAGTAAATATGACGAATTCTGCTGGTTTAACAGGAGCGATTCCTATATCGATATGCAATTCACCAGCATCAATACTAGACTGCGGGTTGTTTTCTTCGTCTACCTTGACGTAGAAAGCTTGATCTTCGCTATCGCCTACCAAAGCGCCTGTACGCCATACATTACTGAGATATGCACTTACATTTCTCTTTACCTTACCCCAGAGTAGCTTATCATTGGGTTCAAAAACAACCCACTGTGTCGCTCTTGCGATAGATACTCTCACCATAATGAACAAACGACGAATGTTGATGTACTTCCATTCTGGATCTGCGGATAGAGTGCTTGCTCCCCATACACAGTCACCAGCACCAGTAATACTTCGTAAAACGTTGATAGCACGTGGATGCAAGTAGTCTTGTTCACCTTTGGAAGTATTGCGTTCCATACCAACAATGGTCTTCAAACTACCAACCCCCATACCAGCGGGAGCTTTGTGTACACCGCGCTTGTTATCGGTGTATGCATAAATACCTGCGATGTGGCCTGAAGGAGGAACTAACTTTTTACGCCCTGTTGCTGGGTCAGTGATATAAACCCACGGATAGTACAACGCACTGTAAGAAGTGGCTAAACCTTTTTCACCTTTGTAGTTACCCGTACCATTTTTAAAATCGGCAACATCAGTGGGCTCTAAAGCACGTGGCGGATCAGCGATAAAAAATGCATCTTGACGTAACTGGCAATAACTCATCGCTGCAATCATAACAGCGCGGTCTCCAGGACGGTCAGGAATACACAGAAGAAGTATTTCATCAATTGGATCAAGAACTTTTAAAGCGTTTGTAAACGACTTTACTCCGTCTTGTCCGAGGAGAGTACCATCTAGACCATTTTCTAGTTTAATGTCACCATTTGGTAAACGCTTACCAGTACCATTAAAACCTTCTGGAACTTCAACGCGAATAAAAGCAGAGCCGCCTTCTCCGTCTTCCAAAGGATTGGCTAATTCAACTAGTCTCTGTAAATCGACATCGACGTAGTTTTCTTTAATTTCACGTGGATCGTTACCATCATATTCGTTGGTAAAATTTTCATTTTCTTGGTACATGACACTTAAACGAAAATGTGTATCTTTATTTGCATCCAAAGGATCAGAAACGCGCAAACTAACGCGATTTCCCCATAGTCCCTTAGAATTGGCAGTAATTTTTATGCTTGCTGCTGCGTCACCTTCACCAACATTCATTGTTGCATTGGCCGCTTTAGCATCGTCAGCATCTACGCGAACCACAAAACAGCTACTACCACCTTCTTGGAAAAATGCATATACTCCATAGGCAAGTCTTCCGCCTGGAATAAAATTACCAAAAGTGGTGATAAACTGTGTCCAGTTCGTTACGAGAACCGGTTTATTTGTAGGCCCTTTTTCAGCTATTCCAATAAAAGCGCCAGTAGAAGTACTTGCACTTAGAATAGGTTTAGAACCACTTGAGACTTCTTTAATGTATACACCTGGCGACTGATATGCCAT

Protein sequences of DBSCAN-SWA_5

>NZ_AP019860|8936311:8992220|8989384_8989750_-|WP_151972065.1|tail|DBSCAN-SWA
MDIATQFEFSLPMGYVDSQGVVHKNGIMRLATAADEIFPTKDAKVKSNPSYLPIALLSRVIVRLGSIEEINTDIIENLFTKDFAYLQDLYNRLNEHGEDAFRTKCPNCNARIKVEVPSLGE
>NZ_AP019860|8936311:8992220|8974075_8974564_+|WP_151972043.1|DBSCAN-SWA
MNYFAFVIALFFVGCSSNLMVLNKELIDKFNLSEENLKSLQVYVSEDVEMRKIEDNDSIVKDGQITPNAQKDIQDVIIEEMTPGVILIVDEDILAVSFQKGSALIFSDQDAAYIISTNDGKVNFNGSEYLLVDGFDAFLYVDANFEEVSEKTQTITGQPIDE
>NZ_AP019860|8936311:8992220|8976139_8977123_-|WP_151972045.1|DBSCAN-SWA
MKDNGSRKESSYLNFLPRIFRETPDKDLPPFFDSYLKIFERIWGEVDDDKLFDYVFSIPLSFRKDIRNGEVNQKLRKEFKQAGHDLTRNARLVTLTPKKKWSLHDHDHTYLIHRGDDEFVVYLSGRKGIEELLDVIADFFHPRFSFLFSKVNTEFIPELDNRDLQKLNRYFTPNKSFDDWLEEFLFWFAGAVSLTLRKQWSIHKKRQVIAEIIPLYRMRGTKIGLEKYLSIYIGEKIRITESIKPMYLGENTVVGGAFTLEGAPYFFDVYVTLKRMPVHELRMTIKSLIEIIETEKPAHTNYKLHIDMPTIDVEKHSRIGVDTILGK
>NZ_AP019860|8936311:8992220|8955214_8957512_-|WP_151972013.1|DBSCAN-SWA
MKLLLLIFCTMLCIFADDDVIFDEPLELEEQEVQEKQNLPEKQSDVQKTPHEKKPEFEIIPNSNMKRKQAVEEQKKAQEEKNAESVENDNWALNETVVTPDTQESKKFDLPSVVYSLDHEVLINERMVRSIPEALKQTPGVMVQKTAHSQGSPFIRGFTGFRNLFLIDGIRLNNSIFREGPNQYWNTVDFFAVERLEIVKGPGSLIYGSDAVGGVINTITRERERYGDDSLLNSRLFYRYSSGEQSHMARGEISGNYGYDFGFVGGVFYKKFGNIIAGGDSNELDKTGYLEMGGDFKLNWFLSNHEELVFGYYGVNQNDAERTHKTIFAKSFRGSAVGNELRRRTDHDRHLTYIQYRMYDLEDFFDNATFTVSWHYQAEEQDRIRGDGRRDIQGITTNTVGFLARFASNVGFGQLIYGGEYYRDFVRSFREDFNADGTFNRRRIQGPVADDSTYDTLGVYVQWEMPIHEQFTIIPGVRYTHSWLEAGEVEDPLTGNEVSIEDDWGGFIGSLKFVWALNANWNIFGGVSQSFRSPGLSDLTRFNSARSNEIETPVDELDPEYFISYEIGLKAQYSNWFFQGSYYYTQIDNMIIRFPTGNIINGEVEVTKDNEGDGFVHGVEFEAGYNITPQWQVFGGFAWMEGIVSTFPEANSNKEDEPIDRMQPAQGFVGLRWNHPSRRYWAEGVVTMVRGQDRLSTRDAADTQRIPPGGTPGYTLYTVRAGARITDNITVSAAIENITDKDYRVHGSGNNEPGFNGILSVDLNY
>NZ_AP019860|8936311:8992220|8964201_8964849_+|WP_151972025.1|DBSCAN-SWA
MYGHIFAIIFLIFIILSCYIVKKYATKFSIKNSLYGILFTTLMVFVWAMTSPCLCRERVPLILIVLPALFILVISAAVPQRKIRKICCYSIAITAFILTEFHATLHHGGGYTSRQNYAQVKKEERKYIMLSYIKYLPYTVEYKKYPAGWVKDMNLPLDEKIIQSFDISLPEGVVTHWHSFFTSLYKKKPEKNYSLWFPGGIFEKHITKAHLKAYE
>NZ_AP019860|8936311:8992220|8978280_8981772_-|WP_151972049.1|plate|DBSCAN-SWA
MMHFHLDHRTAEDIFKHTVELAREYCPEWTKDWPENVNEINTKDFRVVVLKLFSELSETIIEQLNILPYKYLVAFLDLMGVYPLPAEPAKVPLSFTIAEGATSTYVPFRTQVASSENGDVIFETQEGLSVFHTPLQQIVSLNPWFGQFTNHPLILEEQQQGFYIFGKDDKEQYIPHKMYLGDSMIFSSEKPVDIKIKIIGSAKNFLPYFSIWKDSTGKVYEPKNKVGEEEFELTFEGIGPLEKSVVNGIEDYWLSVEPDFTEVKISEEVILPKISRVSADLKVSNLLLDSAIANDSSVEIEKGFYPFGETPKKLDTCYIASHNFAKTGAQISMNINLQEDLPHINPTSYTVAKSDIKDLFLLKRRLISNSRISKHLQTKFSAELKGEIDKAEEPDQVSEKVLEALNAMIDSEGLLYDKKAFKDVVLREEARYYVYSSDVEERDVKHINRLLLEDIFHTELQKHVEVELSWEYWNGERWLSLEEKETVDKEKDPKDEREVEDEFEVADKREVEDEEDAREDENEVEDEFLAVEKSKKAKSFEFQDDTQGLTKSGRITFVCPAMKSVEINGVKHYWIRARISSGTYGIPGKYLKTRNILEILDGWDDIANILIKEGITGGVRYQTPEYTPPFIENVVMDITFREKEFSHIQSHSNFEYFIHDQQKTFYPYRPVIGENPSLYFGFNKNVGGIAYTLYFAMREIYNDKDIRTLVKSTSKKNGIASAAVTWKYFDGTTWKTLEVENGDSFFGSGEITKFFIPKNIQPMHKFGKSLYWIKVEIEGDKVVSPSLKGIHFNSVWAKNSVTITNEILGSSNHTPNLKFQLTQTPILKNQQLIVHESKLVPNEERELLFAEEGQDAIFTKEGKTWVRWHEVLDFSGSTPFSRHYTLNRQDGTITFGDGLKGMIPSAGKDNIVAKIYSSGGGRSGNVSIGTVSSLTINIANIDSVNNYAVALGGNDQESLDDAVKRGPQTIKSKDRVVTKEDYEWLALMASQEVAKAKYIDSNRGEVTIAIVPSDESEIYPKKALLDNVREYLQKRALLTITEGIRVIGPRYQKVNIITEIVPTSVTEIAQVEEKCLRFLSNFLHPTKGGRDQKGWEFGSRILIADVVRILNSVENVVSIKKITVEKVQEGVVAETAYGSNQGWITLEADALPIAGNIQINITA
>NZ_AP019860|8936311:8992220|8977127_8978264_-|WP_151972047.1|DBSCAN-SWA
MSLPVPNLHKKNYDELREEMISSIKKYNSEWTNYNASDPGITVIELLSWLGEHLLYRVNHIPEKAYLNFLRLVAGATGNQIDDVLSQKDLDLEYRELLEFLRELEDYFVFSITEDVEEIVEYLSKADLSETIRKAFAAESIEISPYAEAQINSDDEWIIKDKDQYLIRYENLMLDVFKQGKKVDLGQIRQAISRFANSRYRAVTKEDFELLAIKSTENRSLSKVRRAIVNERKDLGKIEVIVIADEENSYKELLPVVDKYLSERKLLGTWLEVKKADYTSINIVAKIMIPFHVPENAVVKNVKKKILDYVDPIRGYHDGSGWPYKKPINIYELTEIISKEEYVSGIHHIYIDDELVEKPVKGLIRIEKMDIQVVYIGD
>NZ_AP019860|8936311:8992220|8984108_8984837_-|WP_151972059.1|DBSCAN-SWA
MVSLNPFFPSEVDYRVTNSQRAFIKNEDTGEEFTVMFNPEGYSYKLSADDKEGNEKDEDVLTVTGGDVTASSESVDLPFHSTGIGDLDITLQYHAYTSSIDIRSEMMKIQELTLPTQSSGSVRRRPECSFNWEEFYYLGYITEAEAKYTMFDSDGKPLRAELSLNFKAIIPEKDKNKYSGFEGCRKTWIVKGNDRLDLIANAIYQDAKQWLFIARENDIDNPIKFPTPNDIGRVLILPDLPT
>NZ_AP019860|8936311:8992220|8969677_8970346_+|WP_151972033.1|DBSCAN-SWA
MKKFKAKTKKRIIYTVLTTFIFAIGVFFDVFSIATKGLDAYKDYQVTTSMNKIENFQQDEDLNKEIAKLSTQKQKLETKQAQCLSAINILDGKIQELATDKDTFKLGTAEINKESAQKLHKQLTNRHKNLTKKVEYVNTILVAKQEQFRKANAIRDQLEEDGLEIQMQKLEIEKLQKEITDLQKQVQEKQDYINQKAQDISNEDSAQQEADIDNVIFNINSK
>NZ_AP019860|8936311:8992220|8944298_8951237_+|WP_151972007.1|DBSCAN-SWA
MQKNMFFFACPLCHAKLVNEIAEVGETRSCTNCNGQIEIPNPPERIPPFAQVTKVEQAIVAICPYCKNIERLTSKSFGTCISCSQCHIQIEIPRVQAAKLQLRLSQNAVVADGKSTVSITVRTVDRNNNPVPAQKVQIFIERQRGQNQKIATTTKDNGQVTIAYTANVYSGVTRIKAVLNEQANTKCELILKELNGIKDERIKIAKVDFSPRDENEDLQGKITLENRNEIDIDLLSVVLELSNDLQWKSDISKVKILAGDKYIVPFRIDCSQPEIPSIKAKVKTLVQLPNARKTFVKDIDCVVPTKGKINFAIQCAPTQMAGEKFALEIRAMRNEKLVTSFHKTLDVMFSFAAQQAKNGEQPQAPQQYQLSFHEGIATSEEVFCAFASQKEAKITLEYDQQEVTKNIEITPAQKPQFIFHLTSPQINGEFLKGKNTITVCDIYGNIIHDFNKPLTLTLENGNLNNNKDTKLQLQPENGTIDLTAAEVFCVVDDVSQPAAILCQCDGITIRDSWQLESLQCDVQLENIKLKNKRILEGNSGKITLEASISPAKFSIEKIHIIYEKTAEENVKVQGDFAYFNGKLEVSFPTKPRTISGDVSMQLVMDLINKTTGEIKVVSSQKIPGLFIEKKGRTFTTICNEDTCAGKPFGISIEAKYGNFIDKSYQGEKNLFLYYGARKETTDLPQKIALEFVDGKAYTGKIFEFQHRQQITIGVEDSEIGGAKGTFSCLIASGVLDHFAIHVEPQLSGKPFTGDNYIVAKDKFDNIIDSFGDHVGISTENAYFYNENFSSVIPGDYFANGKYRFSNFCMTKINIDEPSYISLRCNTVVTKFPVELQPQHGVLVCKNIAAQESLVECGDTIHFNLHLYNNGETSIQAKRILLAIGDNTLCIDEETEINAKEHFRKNYTFELRKDIISANINVYPSVETIDPVTNEEQSYSFGHRFCLQVEPKDRTLQFSMPDQVTAGKKFALQVQVCREGETDVTYNRKSTLQLQGHPTTAKTMIPDCLELNFYQGVAKTPEVFCLYKSQERYAIDVVLPGPGGAESMLTLPQCKANQTKTFHVTCVQKQVACRPFDGNFIVEAHDEYGNINEDFADKVTLETIGSGSLYFNNEPCVIHPQQFNAGKARIVTQNLRYDSTLQETENVQILLRSSQCTSRFPIEITPAPAILQVVNVAISNKKVQWNESNYVVSIHVENNGQTPATIRDTQIQFYINDRKVDEGYTITTKKKPQIMPGERGMLPVLVALNDQVPLGKHDISVRVEYHDEYYGVSDACTHRDDAWQVEPCGREIIFSTEEKPRMLEQFAANFTVMLNGEVDKTYNGKRVYLCSCKDKVDKKIPRKLKLTFYEGMAQSDAIFCFREKAQNVQLEFLEMEVGGASGKVQLSIYPERWPVVIKRFMTSVQRFCIEHRRRIVSVLVALLIILLGFWHWQRVKITQSLRIVSISGTVTVDGKEVRENDLVRQYQNIQLAPGAFCVLQTHNKATVKLYNSANVYINSVGRSLISSTYDNELNVKKGDVSYQKTTTVQQESFPRIAIPDADRMDVSSNKFRVGVKENEGSLVSVYQGSIGLTSGGETVSVGENQGSSVKKGQAPSTPRSLPKAPQWILPNKDNEVISTNAIPLEWRGYQGIDLYNLEVFTQKNPQIPLQSEDVGAETEKVEHKLRGVDNGVYYCQVTSIDHLGFASEPAMSKFFSHEVLAEKCEIVIQGFDVKSGRFININNFSIGEQQYTNNSEITMGIHKITIRQPGYHPFEIEANLNKGEDFKKLDARLIPKPRSLKWIMSPDVGERSQCKITSITQNKKPLQQLPESLLPEQYRFDIEIEGFEKFTKKIIITPGEDAQKIIMPIIAKKRTIKYEINTGLKQYKFNGIVIFNEQQNPQSILPGKYTLQIEQPGFVVVNKTIDVLPKNTSFTLREKITVKKRDVIFYVKKDSGNVPQAQIIVEQEENKRSLPAGTSHKLHPGEWKIRVVAPGCKEITQKVNIPPGEQSFEYKVTVVAQNVPLELNIENAVPVNNAKLTVIDANNRQIVFPYTRVSMLPPGEYTLKISAPGYQQFAQKVVLRTGERSVYNVNLQPVLVRVLPVIIDPQKQLQEPIKAIVHNGTYSEELLLPPGNYTIMVISERYGELPTEVNINVGQDIYQIYADLPYNERDFSFSVYDVLHLGNMTISSPKELRIDNQIYRLQVKEDGRDVDTNKIDINSLGSYVVVNAFAQTQKLTFHIGYYNLNVSLENYEEAMPLIFVSIDVNKFLQHLEKENDMAAKIARLQTTFQVSEIVNNLGKEQRQFLREFIIQLQEESQQDLRHFLRVLGE
>NZ_AP019860|8936311:8992220|8982390_8983068_-|WP_151972055.1|tail|DBSCAN-SWA
MSFVDMFYQSENQSRVTGVFIGVVTNNKDPDKLGRVKVRFPKISKDNETDWIRIATLFTGAEFGSFFLPEVKDEVLVAFENGDINMPFVIGSLWNGVNKPVEDNADGKNNFSVIKTRSGHTLKFDNTDGSEKIEIIDKTTKNLITIDSSTNTISIVSDADITMTAKNGKIALDASDVEIKGSSSIKIESSGGLDAKASGTANFEGNTTNIKGSTTNVKGSTVNLN
>NZ_AP019860|8936311:8992220|8984836_8988586_-|WP_173013686.1|DBSCAN-SWA
MNAIKYIKPQNLITQHLHRENLNVKIWEKYRAPMMRTEIFPLVFQENPMVEPEETEETSTTTNIHNINFFLKHFERILQTNLEDKTNLHSFFPLYSLQNIQKHTQKIAQHMKFFNENVQQNMFSKTSQKQYKYLYKNSQNTHLVEATTQRKSSMLQVVNNRQGNVNNAAYRILQRKSANTRKMLQVVNHLTYNTPQQYVEEVDNTSQTRNVARTSTNSLSQVLNHLAYMLPAETVNNATYIALQRKSTNMRKMLQVLNNLTYSTPQQYVEEISNTSPQNRNVTQTNTNSLLQVLNHLTYTLPGAYANNVAYTTLQRKSTNMRKMLKVLNNLTYSTPQQYIEEINNASPQNRNVTQTSTNSLLQVLNHLAYMLPAENVSNATYTILQRKTTNMCKMLQVVNDLTYSKPQQYIEEINNASPQNRSVTRTSTNSLLQVLNDLAYTLPAGHTNNVAYTTLQRKSTNMRKMLQVVNNLTYSIPQQYVEEVSNASPQSRNVARTSTNSLLQVLNHLAYMLPADNVNSATYTTLQRKSTNMRKMLQVVNNLTYSTPQQYIEEINNASPQNRDVTRTSTSSLLQVLNDLAYTLPGGHTNNAAYTTLQRKSTNMPKMLQVLNNLTYSTPQQYIEEINNASPQNVTQTSNNSLLQVLNHLAYMLPAENINNATYTTLQRKSTNMRKMLQVVNNLTYSTPQQYIEEINNASPQNRNVTQTSTNSLLQVLNHLAYMLPAENINNATYTTLQRKSTNMRKMLQVMNNLTYSTRQQYIEKINNASPQNRNVTQTSTNKLLQALNHLAYMLPAENVNNATYTTLQRKSTNMRKMLQVVNNLTYSTPQQYIEEINNASPQNRDVTRTSTSSLLQVLNDLAYTLPGGHTNNAAYTTLQRKSTNMPKMLQVLNNLTYSTPQQYIEEINNVSSQNRNVTRTSTNNLLQVLNHLAYMLPAENVNNATYTTLQRKSTNMRKMLQVVNNLTYSTPQQYVEEINNASPQNRNVTRTSTNSLLQMLNHLAYMLPANHTRNVTYTMLPRKNASMRNMLHVGNHLTYQQHMENTPEISRQGSHQNKLLQVLSNISHMIPKQGNTVLQRRSATPNMLYALNHFTYKTPQTDNHAYYPTNSKMLSERLVSLRDRVANQFTQLHNKYFFTANNPLSHRIYVNHESEVKPLNTSSSHQRLQYKRRETIPKYIAVQREQLPLKYKENPQKQIIEEKKKPQKNQRTTHIHVSDTKINSIATRVYKILEKKMSIEKNRRGIF
>NZ_AP019860|8936311:8992220|8939166_8939589_+|WP_151972001.1|DBSCAN-SWA
MILQQVVPMVIQYAPYALMFIEETNERTIAQNDLEKFYRDLHNNIQKSDDNLNELSFNLRESLARKNIKIQSIYVVNIKDVSEKQLTHFFTKLSTQGKIHYQFVKANTAEYKNKIAELRLQNNVTVHTTQIAATNLIKEY
>NZ_AP019860|8936311:8992220|8983064_8984099_-|WP_151972057.1|DBSCAN-SWA
MGKPIAKILIDNSEADECKMAKLIEVVVEEELNLPTMFYFYLSIIDDESGPWKNVDLSKFAPGKAVTISMGLDTEKELFKGEITAVDISFSSVPYIEVRGFDRLHRLQFGRKNRSFAEQKDSQIVSTIASEEGLSATADATTTVYPCLFQFNQTNYHFLLERARKIGYELMVDDKKLLFRKSQEDKSASISLNFGEDIFDFNVSLRTVRQGAVVETRGWDVTKMEEILGSGKAGDEISKMGGSQTGHAMATSAFKSAENTIVNENFVDKSEADTRAAAFYNETQQDFITGEGTYSGTEQIRVGTTIEITNLGDKFSGSYYVTGTTHVLNKKQYTTKFKVRKTGI
>NZ_AP019860|8936311:8992220|8968086_8968512_+|WP_151972029.1|DBSCAN-SWA
MSTNYQQACAIPYRMEDKAIYFCLITSRNHGDWIFPKGCIDGEETPQETALKEANEEAGLEGEIVTDLGAFTYHKRGFDLLTSVQLMRVTHCKNTWLELDRKRCWVSSSKAQKRIERVEMQKALQKAIDWLSQQQTHNQNQ
>NZ_AP019860|8936311:8992220|8970389_8971571_-|WP_151972035.1|DBSCAN-SWA
MRTLIVCIAFLAVPIVVAQDFEISFIDKSEIMKFAKETVKVSINGDNIPDEVEKLFVDSGKKTTLKDHLSLKEFVDTAEKDIEEMLDLLSTDKKNFEEKQQLVNDFSENIKKLEELVEKVAKEIETKIIEKQKVKRVFNSNSIGWEVEITYPRFRYEYVIDEQNKAYESFVKDFKEEEKEVKAKIYREKQEKRFKKEVLPKINKIKRRAFDNIRNCLKSDKAINELEGLYDDLQEYLEKDMVAKLRGEKSYADLQDKFEEHLGKMKDFPNFIRYLVQDMNKILNLVKGYKEFRLHPKDAQLLERIKNDLQKERKDYLSMQKKAQDVNASFASDKALARMFKRFKKKKEIKKFLASVGKSKKAIRKIDAEVPVKKFKKLLGKIRFIIVKKEDLK
>NZ_AP019860|8936311:8992220|8974787_8976086_-|WP_173013685.1|DBSCAN-SWA
MSPQRVNFFKGQLLRVKDFKDEQEYHVEMMRMHHRYLHTWGIINGLRVNAVRQTISIEAGNAISANGDFISLSKTLNIEDSEFPSNKFHVVVMYDEKMAEPVEEAGIKGYSRIIETGKVDLVSSPDRDSHVVLAKVIVKSDGIKIDGSGRRSSGLAVTSETGEKLSIYGKLYEKEESGLFFDAPWAEFAGRLLTKNLKVTGTAIFGNDEDDHAIFNSVIHPRIKPNKPLPSNRYPGRKLQIAGDVEFQEILSTPDGMIVSAGKDISLISNSGVYIKTDNPGANNLGGHLIVEKDLRVLGKLNAKTKQFVIDHPTNHEKDLQHSTLEGPEIGVYYRGESQLINGKTTIVLPEYFEALTHAENRTVLITPKCDPGENKTSALAASAVRNGQFSVTAIDDNNKRQRFYWEVKAVRSDVPHLDVEVVKTTDTLVKK
>NZ_AP019860|8936311:8992220|8951283_8953953_+|WP_151972009.1|DBSCAN-SWA
MAQQHHFDTCKAYWFTSQTVLCKLPTEAKDGDARLYYVENGGATLQNLQQHPFITLQARESNTIAVPRYLQNHMQFNVDVTNEKIRQLVQKQLIFAIVQKEQCLFATGVQLWSLFDHTFRYEDSLGVQFTNDKPILRLWAPSAKSVKLHLFDTVKNTKPQILHMQYQHHGMWQIHGEKNWKNKFYLYEVEVFVPKTNRVEKNLVTDPYSLSLAQDSTHSHIIDLDDVDLKPEGWDQLQKPLLKDFMDISLYELHVRDFSILDSSVRPEFRGTFMAFTDTDSFAMQHLQKLSQYGLTHVHLLPVFDIATIHEDRQQQKTCEIPENLARDSKIPQELIGKIRDEDGFNWGYDPFHYAVPEGSYAVNPQGSARIKEMRSMVTSLAKIGLRVVMDVVYNHTHSSGQHQRSVLDKIVPGYYYRLQQNGYVQNTTCCPDTATEHAMMEKLMIDTLVIWAKYYKIDGFRFDLMGHHTVDNLHNIRRALDQLTPEKDGVDGKKIYLYGEGWTFGSLHNIYPQKVMNQINARGTGIGTFNDRLRDTARGGNFEHRTKSDQGFVTGLFYDYNNCADNSETSGNLQHQRQKLVNYANNIRVSLAGGLADFPLYQDNDKTVYGFEIDYRGAPCGYTSQPYECINYISAHDNYTLWDQICAKAPFHNNNRTPNTATTTERIAMQNLGLSLVLLGQGIPFIHAGSEIARSKSGDGDSYNSGDWFNKLDLSYATNNWGVGIPCKEKNYHEWDFWRPRLQDENLQTTTPHILECFAQFLRVLKVRYSSKLFRLPNAKEIKRRVKFLNANAQNLPGVIVMLIDNSDFVFDKQYKNIVMAFNAAPQQVEFSHALLQGQWKLHPALTEPVFISVRGKKHRIDSNLREVAHHQKLILPPRSCTVYLQER
>NZ_AP019860|8936311:8992220|8939870_8941445_+|WP_173013684.1|DBSCAN-SWA
MKLQILSGPGKGRIFHIQKERVTIGRKADQDIRLVDDVKISRCHCEIVHDGADYILHDLNSVNGTWVNDERVTYAQLESGETFTAGQTEFLILNEQESAVTLSSSPTAHLNFSTISTARLSIENSDITVLKKHIAVFQKVSESLVGKLQMENFLEAIVEIIIKAIHAERAFVLLVDQNMQFSEPVVVKNYATSATVSETILRKCIEDRLAILIEDTQSDSDYKNSESIRRSSTRAAMCVPLISKDKVAAVIYLDSRHEQIFHQNDLKLLASIAKQAELAIENIKLYEELQKKHQELKSAQEQLVKNEKLSIVGTLATAISHDMKNILTPILGVSYIVLKNDQVDPSLREAFERQIERLQSLTQQLLSLVRTDPIKLAMGNINDKVEQSLQLIKTEARCQKVTIKRNFTADLPSVYMDVNRLDQVFINLCLNAIQAMAEQEKSVLEVGSHQDDTHVILYFKDNGPGIRPEYQNLIFEPFFTTKSTGTGMGLFSCKKIIEKDHKGILEIESHVGEGTTFTIKLPKK
>NZ_AP019860|8936311:8992220|8957700_8958555_+|WP_151972015.1|DBSCAN-SWA
MKAHKSILISLAIHLAIFGVSFTIFVGQKQKSKTPISYNIQIHVARTTHLRDNLHMTPTVFEPKINDPRSSHVDITQQKDDFAQPIVEREQRPVKNYERFGTLRLTPKKPKTKPQKNIAKSTVKPPKQKTATNNKKSSAVVTSKNSGGKSQSAGGQPTAGGSRSHNPHGDNTAGKRAGARGGSAAGGGSTAGVPAKIERPKLRKKYKIDYPQAAKRLRLSGSLMLKIKILKDGRVDQVEIVKGSGMRMLDKAAMKSVKTWLFYPATKNGNPVNSWIKVPITFRL
>NZ_AP019860|8936311:8992220|8971589_8972102_-|WP_151972037.1|DBSCAN-SWA
MKYLIFSLCCLCMGCSSLIPYTDGVVESYKLTDSEIKGLQFYTEGDDIILQREVKRVKRDVESSLEEESGSFIDEIVLEEGTPGVLCHFSETHIGVSFEEKFCLVFAKVEDGRYGLGYIDGFVNYYNLENGKTFQFRRVHPYEFTYIAVDEDILARIDKLRTYLPGRTVE
>NZ_AP019860|8936311:8992220|8981768_8981972_-|WP_151972051.1|DBSCAN-SWA
MDTFAKEAYTKLKELREEWDAGQKMLVQLDAKQQELEQKRKDLQQMMLRISGAIQVLEEILPDAEEQ
>NZ_AP019860|8936311:8992220|8981976_8982366_-|WP_151972053.1|DBSCAN-SWA
MAEDHDFLGKGWKYPMTERTKKSEAGGEDSIAQSILIIIGTMKGERVMRPRFGCDIHKIIFELKNKRTYHTAERYVREALEEWEPRIGNIKVKATPDPDQDSRINISIDYTVIDTNTQRNLVYPFYISG
>NZ_AP019860|8936311:8992220|8964923_8967956_-|WP_151972027.1|DBSCAN-SWA
MPLRILVVIICSFMMSCSTEKSADLQLTNSKRIVDAQPLGLRLFDNGEEEDSLVEGDGDSIELESDGKITEKDKETGQKQDAKKWVRNKKDTNVAQVRVGNDEFLELKSVRTLVSVEGIRTRTVVDHVFHNSYERTLEGDFRYKLPDNASICYFAFYPEGFVSKDSDKEVALPSLPTAAQIHRKKIEDYFAEEESNFGKAKIAHAVPRQKALQAYEAVVRRGVDPALVEWAGGNVFITRVFPLQANQYYRIVIGYEQTLIDVEDVITYQFSCADVDSDFMLVADKSYIESSQMNVATPASESDEFVSYQTRVRNKNVVFRANLTQKFITSQDEKQGITYSYGYVSPQFSSPQYNSRSKRAIFLLDTSLSQEKQEFGMYVALLEKILERNRDIEEFNVLFFDVSSGWLQDGWIANSPVGLALFRDKTQVMHLEGATDVTQALQHMVDTPWLNEQNANVDVFFLSNGQHNWGELSLRKSMAKFRQKLQFSPHFFCYNLGLGTANTVLFDLLNEFGGGSFSSTMQLDELAVAHRRSTLFVENIYGEGISDLVTAGSVKVLYPGQRILLAGKITGNEARITITGRIGTQRKSFVFTVPTKSSGSLAPRAFGELVVRKMESLEDPALEETIVAYARYFSIPGKTCSLLMLESQEDYQEFNVNLQKDSQKIENTMVKQVLENIDASLEKSISSPKNSFMYFWETLKDNELVKLNPQNVEELLSLLDDTHFTFSPQKLRYDFSSQKEGASENFLFYIKKAQSYDAKRNLSGYLRAVSSIVELKSQESSALRVAGYLLLKEQVASHAVSIFTRVRDKRPFEPQVYRDLAKSYAALEKYHIAALYYEILISGTWNERFRQINSIAQEEYAHILRKITQETRESFFQKRLQSIAEKTTQHNDITVTITWTTNDTDVDLWVIEPSGEKCYYENKNTRSGGQISDDVTQGYGPERYALKKAAAGEYKIKVNYFRSNEARISDITFVETTITTHSGSRDARTRSFYTMLTSSKEETHIDTLKW
>NZ_AP019860|8936311:8992220|8968539_8969412_-|WP_151972031.1|DBSCAN-SWA
MINRKEASNLVLDVYRPLREVTGTITANQYDYYRTTEMPVSQTLIKRSGKKWNEILDEINLPHPLDRYTLAMFSRSLHLLEKKIKSIFAIGWQEQSFKVAGKTLRPDSFYVERSLIQNGRFFLLDIKLCVSAAPIAIYKYLPLFESDPFSKEQSQITFFDTWLPEEAVEKPFLHYDEDGQANMALKNNVLYICYLLGKPKNDIVPLSMIASRKSSKKIPRNMEVRYVDFLELPRFYCDLANIDYEEQKVREINHWAKTIKSYILHPPSNVSSLVKEIYKDIKHYCNSAQF
>NZ_AP019860|8936311:8992220|8988717_8989182_-|WP_151972063.1|tail|DBSCAN-SWA
MVDIRTAAFGSTPDLLFLNHRFMVEINGLPIAGFAEISGLEVSIETETISEGGCPFPYTIRTGVSYSDLTLKRGLGLIPFYSWVKDVAEGKTGRVDIIVHLLENIPGPIPLPTKTWMFLNAFPTKWSVSDLNSTDGEIVFEEITMAHHGFKQIL
>NZ_AP019860|8936311:8992220|8961861_8963943_-|WP_151972023.1|DBSCAN-SWA
MNHQNSNTANFGKYIIEKELGRGGMGVVYKAYDTQYDIYVALKLITKEGFSQDDYERFSQEIKALARLNHPNIVRFYEFSTTPKPYFTMEYIEGCTLDKKIKEHNVKSLWLVEVMMQICKALEHAHQCNIIHRDIKPSNILIDTQGVVKVMDFGVAKIDSAHRQNLSQSGTIIGSIHYMAPEQVLGKATYASDIYSVGATMYEALTYRTMYQGDNQMNIFYKIIRNDFIPLRQIRPQISPYLEAICIKCLQKRRKKRYQSFTELHTELKNFKSNRPITAKKYTKWDAFYKFFNRHRFALTSVVIIFLTLVISLFVTLGALKKADQTAQKLQVALEEADQSSEKLQKLNEAMLQSLTYISRQNRHVDLFRDAQFLKPVRDVFAQSLELQTADQYRILRGYVLLESHHEKDLLQAVKDYTAILQKVKNHFMYTNRGKAYERLGKRKKAIADYNRAIALDANHYFAFFNRGVLFQKAKPHRAISDYTQVIKLHPSYYKAYYNRGQVYYDLAKYQEALADFSKVLSIVPEYVHAYFWKGLTYRKLNKADVGLQNFSHAIKVDAKYFRAYFQRGVIYVNKKQFVKAERNFSQAIAINPKFWGAYVQRGVLYRHLQKYDKALADFNLVVKHDSKNFAGYLHRGVLFYEMEDTKKALEDFHTVITLNPRHKKTYHHLFLCYRRLGQKEKMQEYIKKWEEK
>NZ_AP019860|8936311:8992220|8960668_8961574_-|WP_151972021.1|DBSCAN-SWA
MKTVENESLQEIESDTSYVCCAFYLDENNLYYIENSHFSDCSFRSSVALNASNCHFENCGFSDEFELHFDNRELTAFPMEIKNFVDLTGLSLKQNLLKDLPAIIGNFTKMITLDVSRNQIEKLPKEIGKLRNLTYLNLEHLKLSELPGAIGNLTNLKELDLHGNHFDRLPVEIENLTNLSHLNLSNSNLRNLPREIGNLRNLEELELHGNYLETLPTEIGNLTNIPHLDLSNNNLKELPAEIGNLTNLMTLDLSRNELKEIPVEIGKLQKLHSLELYMNSITRSQVEWLQKLLPNCSIYFE
>NZ_AP019860|8936311:8992220|8972110_8973037_-|WP_151972039.1|DBSCAN-SWA
MRYVFWICFLVLTGCFSSTEVNEPPQQTEKVTYDAEACSFIDNKTRVKFVLLVKKMALNEQFQICASEIIKYAQRHYMLDLHANQIVNRYINTSTMKRHLSHLDKIMAETMTKKERQDLYLGMAEILPVTGLTTPEDDQQLFELSVIHNLMCYSGGILQVLKKYEDSVTSDEQRKVVAENKKNYQQKPVVEIDMDAFFDIPQGEEIAYPEYTVGSTGDENTPTPTKKKKAPQTPQQKKARSFVLVNPQEKGQTKGSEGAAAPKGDGGGSSLLEPVAAKVKEVTQPAANQVEQKVRDLITEEVQKALGN
>NZ_AP019860|8936311:8992220|8953959_8955087_+|WP_151972011.1|DBSCAN-SWA
MKKIVVLGAGLMGKAMAKDLAKDYQVTAVDVNPKNLEGLQQLNIETKTADLSQADTIKSCVAPFDLVVLAVPGFMGFDALKAVIEAKKDVADISFCEEDFFLLDDLAKENGVTAVVDCGVAPGLGNIILGHHTQNMQIDNFECLVGGLPTRRSWPYEYKAPFSPIDVIEEYTRPARIMENGQIVIKEALSETEHVEFPEIGTLESFNSDGLRTLLKTMQIPNMKEKTLRYPGRHIEYMKVLRETGLFSKEEISVKGNKIRPIDLTAQLLFPKWKFEEKEHDFTVMRITIEGKENGENKKYVYNMLDRYCSETDTTSMAKTTGYTCTGAARLIAEGHFTRKGICPPEYVGQHEDCLTKILAHLKERNVNVDLQQDI
>NZ_AP019860|8936311:8992220|8958802_8960092_-|WP_151972017.1|DBSCAN-SWA
MSNSTNVVYGLDFGASNTVLSVFWNDKLDVIKLSESSCSLPTLLYYTQYESYMGNDAAYMMLNSIADKGRFIRNVKSALAIEGSDSTFVVDKKKPYVDIVCDYISFVKKVGDRHVGQECSEVVIGIPVNFCTVDDLNEQAKTFLKKAAWRSGFRKVSFVYEPVAAMVNNLQQFREGDIALVFDFGGSTLDFHLIEFHSRFDIRPLATHGIKLGGHDITKKMIEHKVLQHFGLGVTYNSKMLDRKNNKSNNVLVPNSLPFLLLDDDLNRSRDQGILEEIERILWDAEADIPELRFLKDCIQKKLYHHIFAAMESAKIKLSSQPQVDIDLDIANREIKEKLTQDEFNEILSFYKSDILDAFAVLMNSAQMNSDEVNKVVLIGGTTQIAYFQDLLKSYFTQAQIVETEFLFESVAMGLASIACNDRYSSLVC
>NZ_AP019860|8936311:8992220|8936311_8938957_-|WP_151971999.1|tRNA|DBSCAN-SWA
MKTSMEIRNQFLDFFASKDHKIVDSAPIVNHGDPTLFFCNAGMNQFKDIFLGTRQTSDKRVANTQKCLRVSGKHNDLDVVGRDTYHHTFFEMLGNWSFGDYFKKDAISWAWEFLTKVLEIPQERLWVTVFGGDEQDGVPADEEASTLWHEVAGVPKERILPFGKGDNFWEMGKSGPCGPCSEIHIDRGETIGDLALATDPKLGVNGENDRFIEIWNLVFIEYNRNEDGGLESLPAKHVDTGMGFERLVAYLQDKKSNYDTDLLAPIIQETENLCSMKYSAQDTLLSDVAFRVIADHIRAITIAFADGGLPGNKGSGFVLRRILRRAALFAKEYLNTSDAFLHKLVPCVGKIYADIFPEILQQQDHIMLVIKSEEESFSKVLENGTSLFNKLLEETKSKNLKEISGTKAYSLYETHGFPVDLIELMAEQNEVTINHKEWKKAEEKHRELSKDKEFDYNFSMTEIEGLPATKFNGYGKLSGQAKLLKLIGTDKIILDRTTFYAESGGQVSDTGTITGKNFAFQVDDTQKHGEIYVHYGQLVEGNLSQLPRWVSTHVDKQRRRKIMANHTATHLLHSALHRVLGEHAVQRGSEVSPERLRFDVSHPQKITQEQVLSIERIVNEAIAQNTRVSRRICSLDEAKSKGAMALFGEKYGEKVRVVSISNYSMELCGGTHVHYTGNIGCFKITSEGAVQAGVRRIEAVTRGIAIENIQEKNILLDKVQTQLKVGEEQVLEKISQMQDEIKELRKTQKQFEQQQVKIQRDALLQQASDINGVKFVFATLPEAKVENLRDMADLMRKSSTPCAGVISCEKNGKLPLVVFVSDHLADHPKLHAGELLKKVCDLLGGGGNAKRKDFAQGQAIKINQINEAQDLARDYITAATE
>NZ_AP019860|8936311:8992220|8941474_8944291_+|WP_151972005.1|DBSCAN-SWA
MENNSKSNERQNQTQCDTESENGSKKTVADTVHHAQQSDIQETVDIDFATEKSDTPPQTIASLEIVPTEKTKNDSLSKSKTVIDVPSPAKTENIPLRNPSSKNAANKKTAQDLPRVSDEDYEDSWSQKVKSIGATLGKSTSGKDITIENLKGIPNEERYEIKKTLGKGGMGVVLLARDNILQREVAMKLIKGNNITDTSRYRFMREARISGVLEHPNIITIYDISCLDDLYFTMRMIGGVTLAHIIEELRNKTAQSKEYTIVRRLEIVQNICYALEFAHSKKIIHRDLKPENIMIGEFGEVLVLDWGLAKKIGEADAEQASKELNLDFTDETAHGSIIGTPRYMSPEQAQGETKTIDESTDIYSLGAILYELLVLKPAFTAKNVLQLIEMVVSTPAEKKRLNSNGDVIPKELMAIALKAMAKQKYHRYHSVRQLREDIRLFMEGKSVHALRDNWFAKLEKMVARNAAMAMVSFLFVVFLAWGYHFLTVNKASAAAGEQALKIQKKYWVSEVTKQVELSQKRWQDLFQERLDILDVLRSEQNKSSANKLLTKATELNARIEECEQRIETLCKNILNFSANEKIQNILAQNYLDSATRKFRERDYTDFANIQEKIDNAVKLNPQLQTAVKNIKNQGDVFIANSMDEALTLYRVIDKDGLFRLQSIPQITQNKKWQLELGSYGLKTPQYFLPFIVDTQGELRLPIFRLQSKLDNMVFVPGGKFYVGARLLVDDYQHQVDVKPFFIEETEVTFGDYKRFFKAFGEDKHIPRVMLANSWEQLWNDDLQLRFGLQDDNPVFGVNYYAAKDYCKWKSRISGVRFDLPRVKEWEKAARGTDGRTFPWGEKQDSSLTNVAVNQQFGRVAKVKSFTYDCSIYGAYDMAGNVSEWTSTRNENGKYLVKGSHFNAVLDRARTYVSYAVAPEHAGFIGFRCICRTVKIKKQ
>NZ_AP019860|8936311:8992220|8990681_8992220_-|WP_151972071.1|tail|DBSCAN-SWA
MAYQSPGVYIKEVSSGSKPILSASTSTGAFIGIAEKGPTNKPVLVTNWTQFITTFGNFIPGGRLAYGVYAFFQEGGSSCFVVRVDADDAKAANATMNVGEGDAAASIKITANSKGLWGNRVSLRVSDPLDANKDTHFRLSVMYQENENFTNEYDGNDPREIKENYVDVDLQRLVELANPLEDGEGGSAFIRVEVPEGFNGTGKRLPNGDIKLENGLDGTLLGQDGVKSFTNALKVLDPIDEILLLCIPDRPGDRAVMIAAMSYCQLRQDAFFIADPPRALEPTDVADFKNGTGNYKGEKGLATSYSALYYPWVYITDPATGRKKLVPPSGHIAGIYAYTDNKRGVHKAPAGMGVGSLKTIVGMERNTSKGEQDYLHPRAINVLRSITGAGDCVWGASTLSADPEWKYINIRRLFIMVRVSIARATQWVVFEPNDKLLWGKVKRNVSAYLSNVWRTGALVGDSEDQAFYVKVDEENNPQSSIDAGELHIDIGIAPVKPAEFVIFTITQKSPQS
>NZ_AP019860|8936311:8992220|8973033_8974050_-|WP_151972041.1|DBSCAN-SWA
MKKFIIYISILLVCSCKSTPPRKKVVEEKPSFSFARCERVHNEIKVRLALAVNHLDINDSFIAFSPYLKKYLQQNFVHLLSKNKEENREVTVEVLRNYLSYLDGFLSRTLTITERMRIYRELSQTFSMLEYSVLWYEDELYKPHQVKSFLCFAEGLVAALDRYKTSSSDRGDLHLLAKPKQIEMYAYIKSKTNRYENPKKEVTPPVEQKEIDENSAVDKAPLMTDNDSEMERNSQSTWEPIPGEPDAVKVKEPVMPEFKENEKGVIDLSNSFIDEVPKSTNEVTSSTSTTEDKSDGDSGTEREDYEKNDWQSTTSQEPEMIPWHNTVDLSNSESEEEE
>NZ_AP019860|8936311:8992220|8960247_8960406_-|WP_151972019.1|DBSCAN-SWA
MDKANRSAVLQRRRVKQHPENVQLQILLSSSVNLDFIFAKQLLLLHKPVFSF
>NZ_AP019860|8936311:8992220|8990219_8990663_-|WP_151972069.1|tail|DBSCAN-SWA
MADRRDHLDPYLGYRFRVDIDGIGIASFKRIAIPSPETQVKEYAEGGNVTTSKLAGITSYPEITLEKGLFSSLELWEWYNSVITTGAIPNRKNMSITVVDEEGNDGPSWEIVNCWPSKIEYGELDSTNDEPIPETVTIQHEGVKRVT
>NZ_AP019860|8936311:8992220|8989896_8990208_-|WP_151972067.1|DBSCAN-SWA
MTVLQIEHDFELPLGYVDEDGNLHKVGKMRLATAADEVLPMRDPRVQQNPSYLSIIILSRVVVKLGTLKMVTPRTVENLFTKDFNYLQRMYSQINGVEDNSEN

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_151971999.1|8936311_8938957_-|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	2.3e-86	39.1
WP_151972001.1|8939166_8939589_+	hypothetical protein	NA	NA	NA	NA
WP_173013684.1|8939870_8941445_+	FHA domain-containing protein	NA	NA	NA	NA
WP_151972005.1|8941474_8944291_+	SUMF1/EgtB/PvdO family nonheme iron enzyme	A0A1B1IUU3	uncultured_Mediterranean_phage	1.7e-15	27.9
WP_151972007.1|8944298_8951237_+	hypothetical protein	NA	NA	NA	NA
WP_151972009.1|8951283_8953953_+	pullulanase-type alpha-1,6-glucosidase	NA	NA	NA	NA
WP_151972011.1|8953959_8955087_+	saccharopine dehydrogenase NADP-binding domain-containing protein	NA	NA	NA	NA
WP_151972013.1|8955214_8957512_-	TonB-dependent receptor	NA	NA	NA	NA
WP_151972015.1|8957700_8958555_+	TonB family protein	NA	NA	NA	NA
WP_151972017.1|8958802_8960092_-	Hsp70 family protein	A0A0N9QXN8	Chrysochromulina_ericina_virus	5.7e-14	22.1
WP_151972019.1|8960247_8960406_-	hypothetical protein	NA	NA	NA	NA
WP_151972021.1|8960668_8961574_-	hypothetical protein	NA	NA	NA	NA
WP_151972023.1|8961861_8963943_-	protein kinase	A0A2R8FF19	Brazilian_cedratvirus	1.1e-22	31.4
WP_151972025.1|8964201_8964849_+	hypothetical protein	NA	NA	NA	NA
WP_151972027.1|8964923_8967956_-	DUF2135 domain-containing protein	NA	NA	NA	NA
WP_151972029.1|8968086_8968512_+	NUDIX domain-containing protein	NA	NA	NA	NA
WP_151972031.1|8968539_8969412_-	hypothetical protein	NA	NA	NA	NA
WP_151972033.1|8969677_8970346_+	hypothetical protein	NA	NA	NA	NA
WP_151972035.1|8970389_8971571_-	hypothetical protein	NA	NA	NA	NA
WP_151972037.1|8971589_8972102_-	hypothetical protein	NA	NA	NA	NA
WP_151972039.1|8972110_8973037_-	hypothetical protein	NA	NA	NA	NA
WP_151972041.1|8973033_8974050_-	hypothetical protein	NA	NA	NA	NA
WP_151972043.1|8974075_8974564_+	hypothetical protein	NA	NA	NA	NA
WP_173013685.1|8974787_8976086_-	hypothetical protein	NA	NA	NA	NA
WP_151972045.1|8976139_8977123_-	hypothetical protein	NA	NA	NA	NA
WP_151972047.1|8977127_8978264_-	hypothetical protein	NA	NA	NA	NA
WP_151972049.1|8978280_8981772_-|plate	putative baseplate assembly protein	NA	NA	NA	NA
WP_151972051.1|8981768_8981972_-	hypothetical protein	NA	NA	NA	NA
WP_151972053.1|8981976_8982366_-	GPW/gp25 family protein	A0A142EZY7	Stenotrophomonas_phage	5.0e-06	33.0
WP_151972055.1|8982390_8983068_-|tail	phage tail protein	NA	NA	NA	NA
WP_151972057.1|8983064_8984099_-	hypothetical protein	NA	NA	NA	NA
WP_151972059.1|8984108_8984837_-	hypothetical protein	NA	NA	NA	NA
WP_173013686.1|8984836_8988586_-	hypothetical protein	NA	NA	NA	NA
WP_151972063.1|8988717_8989182_-|tail	phage tail protein	NA	NA	NA	NA
WP_151972065.1|8989384_8989750_-|tail	phage tail assembly protein	NA	NA	NA	NA
WP_151972067.1|8989896_8990208_-	hypothetical protein	NA	NA	NA	NA
WP_151972069.1|8990219_8990663_-|tail	phage tail protein	NA	NA	NA	NA
WP_151972071.1|8990681_8992220_-|tail	phage tail sheath subtilisin-like domain-containing protein	A0A127AW39	Bacillus_phage	6.5e-49	29.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
NZ_AP019860.1|WP_151970396.1|6572119_6572209_+|hypothetical-protein	6572119_6572209_+	29 aa aa	NA	NA	NA	6514664-6589538	yes

Protein sequences of NZ_AP019860.1|WP_151970396.1|6572119_6572209_+|hypothetical-protein

>NZ_AP019860.1|WP_151970396.1|6572119_6572209_+|hypothetical-protein
MTKSLRKMGFGANRKKVLRLRNELKIRAI

Self-targetings in the prophage

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_AP019860_32	Orphan	32.2|6585931|36|NZ_AP019860|PILER-CR	6585931-6585966	36	6585732-6585767	0

1. spacer 32.2|6585931|36|NZ_AP019860|PILER-CR matches to NZ_AP019860 position: 6585732-6585767, mismatch: 0

gtgccagctctcattcttgctctagaagacgagaat	CRISPR spacer
gtgccagctctcattcttgctctagaagacgagaat	Protospacer
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