CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
NZ_CP028810	Burkholderia contaminans strain SK875 plasmid p875, complete sequence	0 crisprs	csa3	0	0
NZ_CP028809	Burkholderia contaminans strain SK875 chromosome SK875-3, complete sequence	0 crisprs	WYL,RT	0	0
NZ_CP028807	Burkholderia contaminans strain SK875 chromosome SK875-1, complete sequence	0 crisprs	csa3,DEDDh,cas3,WYL,DinG	0	2
NZ_CP028808	Burkholderia contaminans strain SK875 chromosome SK875-2, complete sequence	2 crisprs	csa3,DinG,cas3,Cas14u_CAS-V,c2c9_V-U4,WYL	1	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

266130 : 278175

Enterobacteria_phage(57.14%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_076841713.1\|266130_270933_-	FkbM family methyltransferase	Q684B1	Sulfolobus_virus	6.2e-05	40.3
WP_039361104.1\|270929_272153_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.5e-11	26.8
WP_039361107.1\|272152_272947_-	ABC transporter permease	NA	NA	NA	NA
WP_039361109.1\|272946_274395_-	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase	A0A1V0SH58	Hokovirus	1.1e-53	28.8
WP_039361111.1\|274780_275680_-	dTDP-4-dehydrorhamnose reductase	I7HXC9	Enterobacteria_phage	2.2e-25	35.8
WP_039361113.1\|275672_276224_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	3.2e-51	53.0
WP_039361116.1\|276208_277102_-	glucose-1-phosphate thymidylyltransferase RfbA	I7I009	Enterobacteria_phage	2.8e-97	57.5
WP_039361120.1\|277113_278175_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	8.6e-85	47.9

DBSCAN-SWA_2

427736 : 436837

unidentified_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_039361348.1\|427736_429293_+	polynucleotide adenylyltransferase PcnB	H7BUW3	unidentified_phage	1.8e-22	30.5
WP_039361350.1\|429328_429871_+	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_039361352.1\|429867_430554_+	deoxynucleoside kinase	A0A0M3UL55	Enterococcus_phage	2.7e-07	25.9
WP_039361353.1\|430599_431415_+	3-methyl-2-oxobutanoate hydroxymethyltransferase	A0A0N7HVJ8	Ostreococcus_lucimarinus_virus	1.5e-36	32.5
WP_039361354.1\|431532_433467_-	bifunctional anthranilate synthase component I family protein/class IV aminotransferase	S4VT78	Pandoravirus	1.4e-56	36.4
WP_039361355.1\|433480_434617_-	molecular chaperone DnaJ	A0A1V0SBY2	Catovirus	1.6e-23	27.0
WP_039361356.1\|434884_436837_-	molecular chaperone DnaK	A0A1V0SH73	Hokovirus	1.2e-148	49.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP028808

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP028808_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028808_1

2456771-2457221

Orphan

Consensus_repeat	Method
AGCAATGTCGGCGGCCTCGTCGGCA	CRISPRCasFinder
AGCAATGTCGGCGGCCTCGTCGGCAGCAACG	PILER-CR

5 spacers

The CRISPR arrays of NZ_CP028808_1

>merge|NZ_CP028808|1|2456771-2457221|CRISPRCasFinder,PILER-CR
AGCTCGGCAGGCGGTCTCGTCGGGTACAACGTGGGCCGCATCCTCACGTCGAGCGCCAAGGGCAACGTATCGACCCGGTACTCGAGCCGCGCAGGCGGCCTCGTCGGACGCAACTTCGGCACGATCGCCGATTCCCGTGCGACGGGCCTGGTGAAGGCGGGCGACTTCTCGTCGGTCGGTGGCCTCGTCGGCAGCAACGAGCGGGGCAGCATCGTCCGGTCGACGGCGTCGGGCGACGTCGAAGGCGGCGCGCAGAGCAATGTCGGCGGCCTCGTCGGCAGCCAGACCGGGACTGTCGACCAGTCGCGTGCGACGGGCTCCGCCCGGGGCGGCTTCGCCAGCTATGTCGGCGGCCTCGTCGGCAACAACGGCGGCACCATCACCGCGTCGTCGTCGTCGAACGGCACCGTATCCGGCGGCCAGTACGCGCGGCTCGGCGGCCTCGTCGGCG

>NZ_CP028808|1|1|2456771-2457221|CRISPRCasFinder
AGCTCGGCAGGCGGTCTCGTCGGGT	ACAACGTGGGCCGCATCCTCACGTCGAGCGCCAAGGGCAACGTATCGACCCGGTACTCG
AGCCGCGCAGGCGGCCTCGTCGGAC	GCAACTTCGGCACGATCGCCGATTCCCGTGCGACGGGCCTGGTGAAGGCGGGCGACTTC
TCGTCGGTCGGTGGCCTCGTCGGCA	GCAACGAGCGGGGCAGCATCGTCCGGTCGACGGCGTCGGGCGACGTCGAAGGCGGCGCGCAG
AGCAATGTCGGCGGCCTCGTCGGCA	GCCAGACCGGGACTGTCGACCAGTCGCGTGCGACGGGCTCCGCCCGGGGCGGCTTCGCC
AGCTATGTCGGCGGCCTCGTCGGCA	ACAACGGCGGCACCATCACCGCGTCGTCGTCGTCGAACGGCACCGTATCCGGCGGCCAGTAC
GCGCGGCTCGGCGGCCTCGTCGGCG

>NZ_CP028808|1|1|2456945-2457140|PILER-CR
GTCGGTGGCCTCGTCGGCAGCAACGAGCGGG	GCAGCATCGTCCGGTCGACGGCGTCGGGCGACGTCGAAGGCGGCGCGCAGAGCAAT
GTCGGCGGCCTCGTCGGCAGCCAGACCGGGA	CTGTCGACCAGTCGCGTGCGACGGGCTCCGCCCGGGGCGGCTTCGCCAGCTATGTCG
GCGGCCTCGTCGGCAACAACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028808.1\|WP_039371474.1\|2447800_2449522_-\|ubiquinone-dependent-pyruvate-dehydrogenase	unknown	unknown	gnl\|CDD\|181661
NZ_CP028808.1\|WP_082139546.1\|2452094_2453804_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	unknown	unknown	gnl\|CDD\|225387
NZ_CP028808.1\|WP_135370735.1\|2465378_2466398_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028808.1\|WP_039369777.1\|2470053_2470602_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028808.1\|WP_039371479.1\|2450464_2451481_+\|1-aminocyclopropane-1-carboxylate-deaminase	unknown	unknown	gnl\|CDD\|183494
NZ_CP028808.1\|WP_046197026.1\|2460576_2463627_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|273865
NZ_CP028808.1\|WP_148668959.1\|2466953_2467640_-\|pilus-assembly-protein	unknown	unknown	gnl\|CDD\|237939
NZ_CP028808.1\|WP_039371471.1\|2447254_2447695_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|236715
NZ_CP028808.1\|WP_039371468.1\|2446322_2446913_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|226472
NZ_CP028808.1\|WP_039371476.1\|2449766_2450267_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|183009
NZ_CP028808.1\|WP_039371458.1\|2441267_2442407_+\|acyltransferase	unknown	unknown	gnl\|CDD\|224748
NZ_CP028808.1\|WP_039369774.1\|2471077_2474080_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|274362
NZ_CP028808.1\|WP_039369787.1\|2464058_2464700_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237939
NZ_CP028808.1\|WP_039371485.1\|2444734_2446168_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|224699
NZ_CP028808.1\|WP_039371462.1\|2442536_2443277_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028808.1\|WP_039369805.1\|2467644_2469804_-\|fimbrial-protein	unknown	unknown	gnl\|CDD\|374909
NZ_CP028808.1\|WP_046544080.1\|2457516_2460423_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|214908
NZ_CP028808.1\|WP_046197024.1\|2464824_2465331_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP028808.1\|WP_052760189.1\|2466477_2466954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237939
NZ_CP028808.1\|WP_039371465.1\|2443310_2444702_-\|sulfatase-like-hydrolase/transferase	unknown	unknown	gnl\|CDD\|224699

Protein	Function_ID	Function_description	E-value
NZ_CP028808.1\|WP_039371474.1\|2447800_2449522_-\|ubiquinone-dependent-pyruvate-dehydrogenase	gnl\|CDD\|181661	PRK09124, PRK09124, ubiquinone-dependent pyruvate dehydrogenase.	0
NZ_CP028808.1\|WP_082139546.1\|2452094_2453804_+\|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein	gnl\|CDD\|225387	COG2831, FhaC, Hemolysin activation/secretion protein [Intracellular trafficking and secretion].	4.77376e-114
NZ_CP028808.1\|WP_039371479.1\|2450464_2451481_+\|1-aminocyclopropane-1-carboxylate-deaminase	gnl\|CDD\|183494	PRK12390, PRK12390, 1-aminocyclopropane-1-carboxylate deaminase; Provisional.	0
NZ_CP028808.1\|WP_046197026.1\|2460576_2463627_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|273865	TIGR01901, Heme/hemopexin-binding_protein, filamentous hemagglutinin family N-terminal domain. This model represents a conserved domain found near the N-terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. Members generally have a signal sequence, then an intervening region, then the region described by this model. Following this region, proteins typically have regions rich in repeats but may show no homology between the repeats of one member and the repeats of another. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, heme/hemopexin-binding protein, etc.	2.13638e-20
NZ_CP028808.1\|WP_148668959.1\|2466953_2467640_-\|pilus-assembly-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	2.0081e-15
NZ_CP028808.1\|WP_039371471.1\|2447254_2447695_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|236715	PRK10562, PRK10562, putative acetyltransferase; Provisional.	4.59687e-35
NZ_CP028808.1\|WP_039371468.1\|2446322_2446913_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|226472	COG3963, COG3963, Phospholipid N-methyltransferase [Lipid metabolism].	1.59005e-37
NZ_CP028808.1\|WP_039371476.1\|2449766_2450267_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|183009	PRK11169, PRK11169, leucine-responsive transcriptional regulator Lrp.	7.82215e-45
NZ_CP028808.1\|WP_039371458.1\|2441267_2442407_+\|acyltransferase	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.11002e-23
NZ_CP028808.1\|WP_039369774.1\|2471077_2474080_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|274362	TIGR02956, sensor_protein_TorS, TMAO reductase sytem sensor TorS. This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems].	4.01216e-88
NZ_CP028808.1\|WP_039369787.1\|2464058_2464700_-\|hypothetical-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	2.65508e-13
NZ_CP028808.1\|WP_039371485.1\|2444734_2446168_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	8.34452e-130
NZ_CP028808.1\|WP_052760189.1\|2466477_2466954_-\|hypothetical-protein	gnl\|CDD\|237939	PRK15308, PRK15308, fimbrial protein TcfA.	6.30767e-08
NZ_CP028808.1\|WP_039369805.1\|2467644_2469804_-\|fimbrial-protein	gnl\|CDD\|374909	pfam16967, TcfC, E-set like domain. TcfC is a family of bacterial fimbrial proteins. These sit in the outer bacterial membrane surrounding the RcpA proteins of the fimbrial shaft. This family is from Gamma-proteobacteria. This domain represents an immunoglobulin like E-set domain.	1.55611e-11
NZ_CP028808.1\|WP_046544080.1\|2457516_2460423_+\|filamentous-hemagglutinin-N-terminal-domain-containing-protein	gnl\|CDD\|214908	smart00912, Haemagg_act, haemagglutination activity domain. This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.	7.14072e-21
NZ_CP028808.1\|WP_039371465.1\|2443310_2444702_-\|sulfatase-like-hydrolase/transferase	gnl\|CDD\|224699	COG1785, PhoA, Alkaline phosphatase [Inorganic ion transport and metabolism].	2.56861e-123

>NZ_CP028808.1|WP_082139546.1|2452094_2453804_+|ShlB/FhaC/HecB-family-hemolysin-secretion/activation-protein
MRRARPLLRSDSIADRRSGRLRIACLTSLALSLHGIAHAQAQVPNAGQSLRDVETLRPTLPVPAAPDLAMPPSDEAPSSATAEGPRIPVSAFAIEGNAAIPAARLDALLVDLVGRELSFGDLQQAAARITAYYREHGYVLARAYLPHQDIEHGVVRIAVVEGRYGQLELHNRTRVLDRALRQPLASLQPGEIVSGNRLERSLMLLNEMPGVDAKGTLRPGAEPGTTDLVIDAERSRFATGSVEFDNFGDPLTGRYRATGSIDVNAPLRLGDRFSLRGLTSNTNQRYYRASYQVPVGPASTRVGIAYSDMNYRIGGSLKELRYHGGADVRSAFVTQPLLRSRRTSVDAQVTYENKHLRDVYGIFDVVGDKTVDLWSFGVSGNRQDGFGGGGRTGFSATVGIGHLSSNDPLDMNYYAHTLGQFAKLNINALRLQALGSRFQLYTQFSAQLSSRNLDSSEKFNLGGPYGVRAFALGAGSGDQGWQATAELRYLVAPGWQLSTFADTGRIQLSKQRWSRERNTVQLSSLGIGASWYGSRHQVSVTAALPVGYTDQVASPTRSPSVWLQAAQYF
>NZ_CP028808.1|WP_039371479.1|2450464_2451481_+|1-aminocyclopropane-1-carboxylate-deaminase
MNLQRFSRYPLTFGPTPIQPLKRLSAHLGGKVELYAKREDCNSGLAFGGNKTRKLEYLVPDALAQGADTLVSIGGVQSNQTRQVAAVAAHLGMKCVLVQEHWVNYEDPVYDRVGNIQLSRMMGADVRLVSDGFDIGIRRSWEEAMESVRQAGGKPYPIPAGCSEHPLGGLGFVGFAEEVRAQEAQLGFRFDYIVVCSVTGSTQAGMVVGFAADGRADRVIGIDASATPERTHEQITRIARHTAELVDLGRPITAADVVLDTRYAGPEYGLPNDGTLEAIRLCARLEGMLTDPVYEGKSMHGMIDKVRLGEFEPGSKVLYAHLGGVPALSAYSGIFREG
>NZ_CP028808.1|WP_039371476.1|2449766_2450267_-|Lrp/AsnC-family-transcriptional-regulator
MKLDRGRASPTDAAPALDRIDRAILRQLQQDASISNVSLAAKVKLSAPACLRRVERLKEMGLIRGIVALLDPKPLGAGMLVVIGFVLDRSTPEAFAAFEKAAQKVSGCVECHVVTGEFDYFMLVRTRDNDSFNRLHAEQLLYLPGVRQVRSFMVLKEILSTHALPL
>NZ_CP028808.1|WP_039371474.1|2447800_2449522_-|ubiquinone-dependent-pyruvate-dehydrogenase
MAKQTMAEYLAKTLAAAGVERIWGVTGDSLNGLSFSLGQIGSIRWMHTRHEESAAFAAGADAASTGRLAVCAGSCGPGNLHLINGLYDCHRNHQPVLAIAAHIPSTEIGLGYFQETHPQELFRECSHFAELVTNASQFPRVLARAMRTAIEERGVAVIVLPGDIALGDGPDELPAWSESAPPSILPADADLDRLAALLNASDAVTLLCGSGTQSAHDEVVALADTLGAPVVHALRGKQFVEWDNPFDVGMTGLIGFSSGYHAMESCDTLLMLGTDFPYRPFYPSNAKVAQIDWKGSQLGHRAPLALGLVGTVKETIAALLPRLTRKTQRRFLENALKHYAAARKGLDDLAVAEPPGRAIHPQYLTKIVDEVAAEDAIFTADVGTPTLWAARYLTMNGKRQLHGSFNHGSMANAMPQALGAQGAHPGRQVVSLSGDGGLSMLLGDLLTARQLKLPIKIVVYNNSLLGFVSMELKAAGYLDTNVDLSPTDFAAIAKGAGIFSVRVEHSENVEEALRMAFAHDGPAVVDVVTSKYELAMPPKIELAHAKGFSLFMLRAILSGRGDEIVELARTNLR
>NZ_CP028808.1|WP_039371471.1|2447254_2447695_-|GNAT-family-N-acetyltransferase
MAIEIRAYEASDLHTLSAIWFDASLLAHAFLGEARLREQRALIEAVYLPKAETWVACRAGEPVGFIGLLDDSIGGLFVAPAMHGHGIGRALVEHALALKGALDLEVYADNLDARAFYARLGFDEISRRDGDDEGLPFVNILMRSTR
>NZ_CP028808.1|WP_039371468.1|2446322_2446913_-|methyltransferase-domain-containing-protein
MMWPNAWRVSALFVREWVGRPAAVGALCPSSRQLAREMADAVPDGDGLVVELGGGTGAITAALLERGVAPRRLVVVERSPAFVQHLRRRFPGITIVSGDARQLERLLPPDAHVDAIVSCLPLRTLPRQDVAAIVDQCHRVLSADGVMIQFTYDLRPPGRHPLGDSAFVACGSRIVWANIPPARIVTVRSVTAEHAE
>NZ_CP028808.1|WP_039371485.1|2444734_2446168_-|sulfatase-like-hydrolase/transferase
MNRIKLAALLCAGAFALAGCGSDDGPTSTAPGPVQAAARNVIFFLGDGMGITTMTAARIYAVGEDGALTIDTLPETAFVKTYSNDAQVTDSAPSMSAYMTGVKTNNEVISMTPDTKAIEPTASLTGNCGANNGKSATTLLEIAKAKGLATGVVTTTRVTHATPAATYAHVCHRDAENDIAAQLVPGGAGYNGALGDGVDVVLGGGTQFFVPKDGGGKRTDGRNLVNELKAKGYAVAQNRDDLLAADATKGGKLVGLFSSSHMSYDLDRGATKEPSLTDMATRALDVLQKNPNGYFLMVEGGRIDHALHDTNAKRALQDTVAFDNAIKATIDKVRQTDPDLKNTLIVVTADHDHTLVLNGYAARTGKTEAGKPGVLGVLRSYQTGSVAKDADGAPYTIIGFGNGENRVQGSRAGTALTDAVTGADDYRQEAVVRMDKGSETHGGTDVFLGAIGRGADAFHGVIENNKVFELVRNAVQL
>NZ_CP028808.1|WP_039371465.1|2443310_2444702_-|sulfatase-like-hydrolase/transferase
MSTIKCIAAALAVAGFACGAAQAAGQAKNVIFFLGDGMGPTTVTASRIYKVGESGQLTMEKLARTARVKTFSNDAQTTDSAPSMAAYMTGVKMNNEVLSMSSDTRAVAPGNDANGNKTVNNCAPGNGQPVATLLELAKARGKAVGAITTTELTHATPAATYSHICHRDAQYDIAAQAAPGGAGYNAALGDGVDVLMGGGRNHWTPFDPVANKRGRADGRNLLNEMKAKGYTVVATRDQLAQAGNGKLVGLFSSTSHLEYELDRVAGKGEGPTQPSLAEMTSKAIDVLSKNSNGYFLMVEGGRIDHALHGTNAKRALEDTAAFDEAIRVALSKVDLSNTLIVVTADHDHTMTINGYSKRGNPILDISRNYRDGQPSKDADGNTYTTLVFGNGANRPNVRASVDSATATNDAYLQEVGVRMGSAGSETHGGGDVMLFADGADAKAFKGTIDNTKVFGLVRSAFGF
>NZ_CP028808.1|WP_039371462.1|2442536_2443277_-|hypothetical-protein
MKRQLLYALACGWVALPALAAADLDAVLVHESRTVSADGVTRTTMYRERMVRRDAHVWVERVLPVAAAGGHGNDHDHDHDHDAGARTGVQPAAAHAGHKHFNFQAAARHVTYDGKTARIEYVDTANRTVVSVPPAEYETTGFDGSWDNAYYVTPPSQLKRLAVAKRGDTPGTRWYEQAVDTPGARGVNRILWSEKLQAPLSVEFRSADGRVVRKLTLTPATAARHETLPWQTLAGYSRKEYADYLD
>NZ_CP028808.1|WP_039371458.1|2441267_2442407_+|acyltransferase
MSTGPRNARIDMLRGVSIVLVLLHHFNIPYSLRDTSLARVFGWDAVHAVARNGNYGVTMFFVISGYLITSNARRRWGSLGALDVRAFYVSRIARIVPCLLLLLALVNGLAAAGVPIFQNHAPEGIAVSFWLVNLASLTFWMNVLIGAYGWVNYALGVLWSLSVEEVFYLSFPLLCIALRRDARLVAFWVVIAAIGPVYRFTHAGDEGGFLYAYFASFDGIAIGCCTALLAERVTGQRLAAPLVQWLVAGAMATLYLAWPIAQSHVAGVTAMALGTAVLLIGAHVNGERVPGRLLAPLGRAGKLSYELYLFHLIVLGGLRTFWPPSATHGDTKLLLLIAYLALSAALSAAIARGYATPLDRFVKRIASRPSARVPDGARF
>NZ_CP028808.1|WP_046544080.1|2457516_2460423_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MNKTYALIWNQAQGCWSAVGETARRRAKPGSTKRVAAALSLLGVVSLPAFALPSGENITAGKADILRDADGKSMRIDQHTDKLITNWNDFNIAGGERVSFYQPGKHSIALNRVVGNNGSQIQGQLEANGKVFLVNPNGVLFGSGAQINVGGLVASTQNIADADFLAGNYRFSGNSTASIVNDGRITAADGGSVALLGARVSNNGVIQAKMGRVALGAGNTFKVNFDGSDLLSLQVEGGAVDAQANNGGLLKADGGEVLMTAQAAGNLLNAVVNNTGAIEAKGLASHAGKITLDGGTVLVGGKLDASAAEAGAPAGSILTRGEQVRVVRGTTVDTRAGNTAGTWTIEAANAGVAKNNAYSLYPAGVSIDADTLSNNLGTTNVALTNTQGDLTVAGPVAWNSDRALTLTSQKGNVDLQQTLSASANASLNVNAADKIRINDAVKLTGRNAHLELNSKNGHTLTNDAAVTLSGDNASFRSNGEDYKVLHTIADLRNVDANLGGRYVIGNTIDGANANFVSIGGATGNAFTGIFDGLGNTISRLAITNPGHHVVGLFGINRGRIANLELKGLSATGSAPRRTLLIGALAGDNFGTISNVTATDVTVSAAGRAYVGGLVGANRGGTIERARVSGRVDGDRETVAIGSLAGANLTLAQKNAPVARIADSHADVHVTTARGTAGGLVGINSGIVETSSSAGSVTMTGDTALIGGLVGHNEANGVVRNTSSTTTITAGNDVVAGGLVGLNAGLLAHSKAGGSIRVGENSVAGGAVGTNHGDVSASRASGMVTASIAGMVGGFVGNNLGVIDTSSATGNVEAGHASLAGGFAGSSRYVIRRASATGDVSAGDGSQVGGLVGQLSGLLDASTAAGAVSGGNVSLVGGLVGNNGGRIRTSSSSGTVSGGYTAKLGGLAGSNFGTVERSSTTSRIAYRSELAQRYGALAGINYGQLIGNTASGNGPDVPLVGFNAGRLQD
>NZ_CP028808.1|WP_046197026.1|2460576_2463627_+|filamentous-hemagglutinin-N-terminal-domain-containing-protein
MNKTYALVWNPLHGRWIAVGETARRRAKPGSAKRVAAALSLLGIVSLPAFALPSGENITAGKADILRDADGKTMSINQHTDKLITNWKEFDIAGGERVTFYQPGKQSIALNRVVGNNGSQIQGQLDANGKVFLVNPNGVLFGSGAQINVGGLVASTQNIADADFLAGNYRFSGNSTASIVNDGRITAADGGGVALLGARVSNNGVIQAKMGRVALGAGNTFKVNFDGSDLLSLQVEGGAVDAQANNGGLLKADGGEVLMTARAAGDLLNAVVNNTGTIEAKGLASRAGKITLDGGTVLVGGKLDASAAEAGAPAGSIVTRGEQVRVARGTTVDTRAGNTAGTWAIEAANAGVANNNADTLYPAGASIDGDTLSNNLGTTNVALTNTQGDLTVGGPVAWNSDRSLTLTSQKGNVDLQQAVSSASANASLNVNAADKIRINDTIKLTGRNAHLELNSKNGHTLNKDVVVTLSGDNASFRSNGEDYKVLHNMADLRNVDANLGGRYVIGNAIDGANTSFRSIGGSGTFTGVFDGLGNTISRLSITGTGPNIGLFGQSTGYLANLTLDSLTVDGTSAARATFVGGLVGDNLGRIENVNAKNTSVSYNGRNMVMMGGLVGRNLGTIDRANFAGRVSGSANTLSVGGLASVNGGTIADSTASADVTLSGSSGSPFQGSYSREVQSIGGFVGTNNGEIVRSSSRGRVSGRDDTSTGGFVGINFGTIRNASANATVTAGKGSYVGGFAGKIRDDGTIANASASGPVWANGALAIGGFVGDNAGGTLDGVQSDGDVTDLASGHVGGLAGRNGGTIRHAQARSTVTTGRNSHAGGLVGTNDGAVSNSSATGRVSAGEASDAGGLVGLNTGELDTVTATGNVTAGNGSRVGGLVGTNQGNRAIVRHAATTGNVGANNSTVGGLVGLNDQGAVIDDASSTGTIAGTFSTLGGLVGENAGTIRASTSSSRIDPASTIYGGRSWGTLVGYNNRSGNIEASSVEGAAQPYYMVGLSIGKINGQWYYGPVDR
>NZ_CP028808.1|WP_039369787.1|2464058_2464700_-|hypothetical-protein
MATLAFPISAAAAIDMVPKDVTLKETVTSVEVINNGDRAEYVSVSLSRLLNPGVPFENERLEPVGEIDQPSIYASPFRMSLAPGQTKTIAIKVLRPVDTETVYRLDVKPVIKVLGTGHAKSSASVVANLAFSGIVRQMPSKTRAALAVACEASGARLTATGNVHYRVEGAKADGQRLDDFNVYPGVPLPVPGRIVDIPGHSVCGAAAAKSPLP
>NZ_CP028808.1|WP_046197024.1|2464824_2465331_-|hypothetical-protein
MLPAVLLAEPVKLTGKTTSRVTAHVSRPNNLFVTDDKGGWFDQGLQMQQLGGWDTPYEVQARLKIVSTSGVFQVRLDSPLTITHQSKPTLVFRTPTVKLAPEGGVPKPLLVGQGTEFQNPAASGARDDSVGYYNLDIAAYPPTGNFKDNTGTYKGVLSMTFEPVIKAP
>NZ_CP028808.1|WP_135370735.1|2465378_2466398_-|hypothetical-protein
MNRISRERGSFGRWCKVVLLFFLAMSVGRAYGYILVLDNLSNGYSGCSWVDNGNGTSTVSVSIDYKSVVGHLGGRLFTSRGILIYTYNRNGELNPSANVARAMNINGKPYESAFVGTGYVMYKNSNYPGPSTGDWTNGSPFIANVVATVSNSVIADWPAIGIRAGNYTDGDDVGEVTGVAYIRFGENRGVCNIVVNPEVPPPPVEITMNMTAPDWNLGDLGQGDSKKTFSDTANQLCFTYPGSVVTGVRFIVNAKNVNGEVANRYRLKNVDDASQFVPYSIKLDGGGSTLSLPNSSNMAMRFASSGKTCFVPTFETTVDSNVKEGDYVDVLIFTVVTPS
>NZ_CP028808.1|WP_052760189.1|2466477_2466954_-|hypothetical-protein
MNRALCRALGALLLLWSSGSFAAGILKLSRTELTLAPDKPANELWVENVGDTPLYLDITQQRVLNPGHLPEQLVPVEEVSQPTLLVLPTRLALSPGQKYRMALKELSMPDESQVWRVTFRPREHIVVDADRDGDTTAPLFVSVGYGVVIYQSLAGAVR
>NZ_CP028808.1|WP_148668959.1|2466953_2467640_-|pilus-assembly-protein
MNFNAKHWALALVALACATVRPALAEGELMVMPAATRVYATHDQKVTVRNMGDAPLFLSITLQKIMNPGVTPEKKVDLGQLDNPGMLASPDKLTLGPGQSRQIELKSLTDPAQEEVYRLYVVPIRSLKVEDAPADKITAPMSVAIGYGVLVRHLPPPGKLNVAWTHRCEDGGITLESTGNVRTLFSNASYDGVKQPQTIAVFPGTPQHFATKRMTLSVQDEPKTLQCP
>NZ_CP028808.1|WP_039369805.1|2467644_2469804_-|fimbrial-protein
MDDSARYVATFNGKTLPGFVRYSATESVLEFDAAKYAANGVSPDDVDTIRNVVSKIDYKRCSKGCDIEVDGYYVTIDKLRRSISIRNSREDYFAPETTFGLVNNQSVDFRASSNGYRAANLNGATWVGLPSRSFGYVSWYANRTQTRGTSYGSQGVSSYYLQKNFAGTYLRAGKQNSIDYASGSVSTLLSPSFDQFVTFGSQSNLQVNRDAGSLVLYATAEGNYEFYRNGRLIMKRPAALGRNEISFADLPGGYYPVQVRLVDRNGNLVSQEIREINNVNFGAGGGNAWHFTVGKEMSDRGGFLMEGAMSRNFRQFYMNASTLVGRGGDWAAEVNVTRPTKIGDVDVTPTLGVLAGERKAGGYVSLAASSEALGSLSASRYLNNDVSRFYAGTSSTSVTYSRMVRKATVGYNYQQSGFGATHQAEVRWNYRPNGLWATFALGVQKGSFSRTSGGYGVYFNMTMQLDKVQASFSAARSGGQTQLSGDYRKDFQDGFGTTTLGVTGNRINSDYGINVYGSRSGTRGDASLNLGYNGDASNVDFNYRGMVAASKDGVAFGRYSNGGSAMLLRTPKLDGMRYGFNVEGSPVGGGSTYAVPLNTYTDVAFARVYSNSDKLDMNIEVPANIVRAHPGQVYAAQAKVDINMVYSGFLKDTEGKPISGKVVETGDVVHRNGLFSIVSKTMLSQVTVDGDGHRYTCSLKDASGNDFRCELPGLKESKE
>NZ_CP028808.1|WP_039369777.1|2470053_2470602_-|hypothetical-protein
MKLSKLVLAMGVTTALFGMAHTAQADTVSKKVTLTAQINDGIFVSKPDGSTWYGTEELEANDYTQTKFSKTLPVRVYTKNPDFNISLASPLKLTNGNYEMKNAKVTLGSAAGDSEVKFGAVQKVTQTVSGNGGFDEVHNLKINVDAPTMVGTNSTNGSYSGDLVMVFEPLAAAGGGDTPASK
>NZ_CP028808.1|WP_039369774.1|2471077_2474080_-|hybrid-sensor-histidine-kinase/response-regulator
MPAKLKRLLAHAAAVGRKPFDPGRVRRQQQMLLYGGGCAITAFIVVCAALVVRLDVQDSLERARSTFLQREAEFYANLQTLDRMLAMLGNRTEELWRKGAPPPQDALRAFAADHGRLAASNAGGGTPFFAMAEVTPARPAESYARYLGAALGQVDRGARYPPVPMRAEPIGGYLIALDGPFLGVLGPGVVARARALPPDTDLRALIDRLMPNGAAKQKPDMQGATFMLDRRYDPVVGRTVIRFARRLDDDDGRPFGWLVLNGRFRLDDIMSPQSDDEDVAVLAADGRVVFGRPRDPALIARAMADAGAQSGKHVVVRRIGTRFAIVDSLSDTGLTMAATFSWRSVARATAVGVSVTLGAALFTVAMLWITIVTFDRRALRPAHRRAIRLIESEAFNRTLIHTAPAGLLLLAAADGETMVRNDAALAYEDGASGLPLGKRIWQACRERQRAGTGERRFVMQQELAVERAGHDTTYLAAHIVRTKFRGVAVLLCTLTDVTARRLTENKLREARVAADDANKAKSTFLATMSHEIRTPLNAIVGNLELMERAELPSVERQRLKTIVSSSDALLRVINDVLDLSKAESNQMALEQIPFDLRRVLQDVAAIFRPLAEAKGLTLECDVAAELADGHVGDPTRLRQLVSNLVGNAIKFTEYGGIAIDARRVRGGDGAGEVEIAVRDTGVGIPEDALPTLFDVYMQADASIYRRFGGTGLGLPLCRRIARLMHGELTVESQVGSGSTFVATLPLPAAPAGWRSAEPEPDTALAPQQRTDVQPLRVLVAEDHPASRALLRDQLDALGHDATIVENGVEAMRAYFEHPFDVVLTDLSMPQLDGFALANFLREQGASVPVIAMTAHATDDDRRRCAQVGVAEVVLKPLSIDVLDEALQRHGGQRGVRAEQAQSGAHEQAPAVTGEIRHALREATLRSLGAIEAALSAGNTNALVIELHSMRGGFALAGDSVARDACAQMEATVKSGGAAAFESHWDAFRSAIEHAMERIGQ

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Crispr_ID: NZ_CP028808_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP028808_2

2981872-2982191

Orphan

Consensus_repeat	Method
ATCGGCGGCGCCATCGGCGGCGGCGC	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_CP028808_2

>merge|NZ_CP028808|2|2981872-2982191|CRISPRCasFinder
ATCGCCCCCGCTCTCGTCGTCGCCGCGTTGACCGGCGCGACTGCACTGCCGGCCATGGCAGGTGACATGAACAACGCGCTTGGCGGCGCGCTCGGCGGGGTAGCCGGCGCAGCGGTCGGCGGTGCGCTCGGCGGCAGCACGGGCTCGGTGATCGGCGGCGCCATCGGCGGCGGCGCGGGTGGCGCGGTGACGTCGAACCGTCACGAGCGCACCGGCGCGATCATCGGCGGCGCCCTCGGCGGCGGCGCAGGTACCGCGGCAGGCAACGCGATGGGCGGCCGCACGGGCGGCCTGCTGGGTGCGGCTGTCGGCGGCGGCGC

>NZ_CP028808|2|2|2981872-2982191|CRISPRCasFinder
ATCGCCCCCGCTCTCGTCGTCGCCGC	GTTGACCGGCGCGACTGCACTGCCGGCCATGGCAGGTGACATGAACAACGCG
CTTGGCGGCGCGCTCGGCGGGGTAGC	CGGCGCAGCGGTCGGCGGTGCGCTCGGCGGCAGCACGGGCTCGGTG
ATCGGCGGCGCCATCGGCGGCGGCGC	GGGTGGCGCGGTGACGTCGAACCGTCACGAG
CGCACCGGCGCGATCATCGGCGGCGC	CCTCGGCGGCGGCGCAGGTACCGCGGCAGGCAACGCGATGGGCGGCCGCACGGGCGGCCTG
CTGGGTGCGGCTGTCGGCGGCGGCGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP028808.1\|WP_039349841.1\|2977432_2978056_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|198289
NZ_CP028808.1\|WP_039349802.1\|2974991_2975864_+\|DUF393-domain-containing-protein	unknown	unknown	gnl\|CDD\|367833
NZ_CP028808.1\|WP_039349844.1\|2978148_2979549_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|224594
NZ_CP028808.1\|WP_039349877.1\|2983185_2984022_+\|(S)-ureidoglycine-aminohydrolase	unknown	unknown	gnl\|CDD\|183011
NZ_CP028808.1\|WP_039349838.1\|2975860_2977360_+\|TIGR01777-family-protein	unknown	unknown	gnl\|CDD\|273800
NZ_CP028808.1\|WP_039349886.1\|2988741_2989353_+\|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl\|CDD\|225415
NZ_CP028808.1\|WP_039349797.1\|2973116_2974424_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187579
NZ_CP028808.1\|WP_039349880.1\|2985578_2986373_-\|phosphotransferase	unknown	unknown	gnl\|CDD\|226100
NZ_CP028808.1\|WP_039349861.1\|2979804_2980224_+\|HIT-family-protein	unknown	unknown	gnl\|CDD\|238608
NZ_CP028808.1\|WP_039349792.1\|2971131_2972334_-\|trans-2-enoyl-CoA-reductase-family-protein	unknown	unknown	gnl\|CDD\|237460
NZ_CP028808.1\|WP_039349883.1\|2986612_2988733_+\|PBP1A-family-penicillin-binding-protein	unknown	unknown	gnl\|CDD\|273955
NZ_CP028808.1\|WP_039349892.1\|2990323_2991412_-\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223682
NZ_CP028808.1\|WP_039349878.1\|2984199_2984574_-\|heavy-metal-responsive-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133398
NZ_CP028808.1\|WP_039349889.1\|2989482_2990304_-\|heme-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|184132
NZ_CP028808.1\|WP_011353812.1\|2972494_2973028_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224427
NZ_CP028808.1\|WP_039349799.1\|2974420_2974891_+\|DUF2269-domain-containing-protein	unknown	unknown	gnl\|CDD\|370783
NZ_CP028808.1\|WP_039349895.1\|2991427_2992342_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|226928
NZ_CP028808.1\|WP_039349864.1\|2980821_2981481_+\|isoprenylcysteine-carboxylmethyltransferase-family-protein	unknown	unknown	gnl\|CDD\|224931
NZ_CP028808.1\|WP_046196361.1\|2984673_2985501_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223377
NZ_CP028808.1\|WP_039349897.1\|2992338_2993430_-\|hemin-degrading-factor	unknown	unknown	gnl\|CDD\|226243

Protein	Function_ID	Function_description	E-value
NZ_CP028808.1\|WP_039349841.1\|2977432_2978056_+\|glutathione-S-transferase	gnl\|CDD\|198289	cd03180, GST_C_2, C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 2; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	8.51979e-48
NZ_CP028808.1\|WP_039349802.1\|2974991_2975864_+\|DUF393-domain-containing-protein	gnl\|CDD\|367833	pfam04134, DUF393, Protein of unknown function, DUF393. Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.	5.13158e-19
NZ_CP028808.1\|WP_039349844.1\|2978148_2979549_-\|serine-hydrolase	gnl\|CDD\|224594	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms].	7.64372e-40
NZ_CP028808.1\|WP_039349877.1\|2983185_2984022_+\|(S)-ureidoglycine-aminohydrolase	gnl\|CDD\|183011	PRK11171, PRK11171, (S)-ureidoglycine aminohydrolase.	0
NZ_CP028808.1\|WP_039349838.1\|2975860_2977360_+\|TIGR01777-family-protein	gnl\|CDD\|273800	TIGR01777, Hypothetical_UPF0105_protein_Rv2216/MT2273/Mb2239., TIGR01777 family protein. This model represents a clade of proteins of unknown function including the E. coli yfcH protein. [Hypothetical proteins, Conserved].	9.45197e-109
NZ_CP028808.1\|WP_039349886.1\|2988741_2989353_+\|trimeric-intracellular-cation-channel-family-protein	gnl\|CDD\|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	1.65647e-63
NZ_CP028808.1\|WP_039349797.1\|2973116_2974424_+\|SDR-family-oxidoreductase	gnl\|CDD\|187579	cd05271, NDUFA9_like_SDR_a, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs. This subgroup of extended SDR-like proteins are atypical SDRs. They have a glycine-rich NAD(P)-binding motif similar to the typical SDRs, GXXGXXG, and have the YXXXK active site motif (though not the other residues of the SDR tetrad). Members identified include NDUFA9 (mitochondrial) and putative nucleoside-diphosphate-sugar epimerase. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.52177e-54
NZ_CP028808.1\|WP_039349880.1\|2985578_2986373_-\|phosphotransferase	gnl\|CDD\|226100	COG3570, StrB, Streptomycin 6-kinase [Defense mechanisms].	1.12675e-81
NZ_CP028808.1\|WP_039349861.1\|2979804_2980224_+\|HIT-family-protein	gnl\|CDD\|238608	cd01277, HINT_subgroup, HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.	2.11415e-47
NZ_CP028808.1\|WP_039349792.1\|2971131_2972334_-\|trans-2-enoyl-CoA-reductase-family-protein	gnl\|CDD\|237460	PRK13656, PRK13656, enoyl-[acyl-carrier-protein] reductase FabV.	0
NZ_CP028808.1\|WP_039349883.1\|2986612_2988733_+\|PBP1A-family-penicillin-binding-protein	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
NZ_CP028808.1\|WP_039349892.1\|2990323_2991412_-\|iron-ABC-transporter-permease	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	7.01012e-78
NZ_CP028808.1\|WP_039349878.1\|2984199_2984574_-\|heavy-metal-responsive-transcriptional-regulator	gnl\|CDD\|133398	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators. Helix-turn-helix (HTH) heavy metal resistance transcription regulators (HMRTR): MerR1 (mercury), CueR (copper), CadR (cadmium), PbrR (lead), ZntR (zinc), and other related proteins. These transcription regulators mediate responses to heavy metal stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	6.478e-42
NZ_CP028808.1\|WP_039349889.1\|2989482_2990304_-\|heme-ABC-transporter-ATP-binding-protein	gnl\|CDD\|184132	PRK13547, hmuV, heme ABC transporter ATP-binding protein.	2.60391e-168
NZ_CP028808.1\|WP_011353812.1\|2972494_2973028_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224427	COG1510, COG1510, Predicted transcriptional regulators [Transcription].	6.42957e-41
NZ_CP028808.1\|WP_039349799.1\|2974420_2974891_+\|DUF2269-domain-containing-protein	gnl\|CDD\|370783	pfam10027, DUF2269, Predicted integral membrane protein (DUF2269). Members of this family of bacterial hypothetical integral membrane proteins have no known function.	1.82774e-57
NZ_CP028808.1\|WP_039349895.1\|2991427_2992342_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|226928	COG4558, ChuT, ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism].	4.03864e-78
NZ_CP028808.1\|WP_039349864.1\|2980821_2981481_+\|isoprenylcysteine-carboxylmethyltransferase-family-protein	gnl\|CDD\|224931	COG2020, STE14, Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones].	6.19655e-26
NZ_CP028808.1\|WP_046196361.1\|2984673_2985501_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|223377	COG0300, DltE, Short-chain dehydrogenases of various substrate specificities [General function prediction only].	1.57795e-103
NZ_CP028808.1\|WP_039349897.1\|2992338_2993430_-\|hemin-degrading-factor	gnl\|CDD\|226243	COG3720, HemS, Putative heme degradation protein [Inorganic ion transport and metabolism].	4.23664e-140

>NZ_CP028808.1|WP_039349864.1|2980821_2981481_+|isoprenylcysteine-carboxylmethyltransferase-family-protein
MKVTSRAAVASCIATLVYLGLAVLGSGGFEAFFSHPQLTVVVVATLAMAVAALFTEGNLSSGERENRDNRWVLAAFGVSGFLLAYLPALTDRLDFWTFGGDAVRWIGVVLYIVGGVLRIWPVFVLGKRFSGLVAIQPGHTLVTDGIYSRIRNPSYLGLVVNSVGWAFTFRSGVGLLLVVLTMVPLVARIRSEEALLRAQFGAEYDAYCARTWRLLPGVY
>NZ_CP028808.1|WP_039349861.1|2979804_2980224_+|HIT-family-protein
MSYDNNNPFAKILRGELSCVKVAEDDATLAIMDLMPQADGHVLVIPKEPAAQIFELSGDAAAAGIRMTQRVAAAVRAALEPDGVFIGQFNGAAAGQTVPHVHFHVIPRWEGAELRMHAREIADAATLEALAQRIRARFV
>NZ_CP028808.1|WP_039349844.1|2978148_2979549_-|serine-hydrolase
MTIPFKKLILRGVALAVVVAVGYTGYMLSRLAPIATGYAAKALCSGVYVSGRPAASVIDVDIMAGVHPLLKLVHPSIDPDHHRATATFAGFAEREADFRPGLGCTLALGPSPGALPAALPPLPDPPSTQPAPVTPPAGIDAQKLQTALDRAFDEPDPARPRRTRAVVVMWRGQVIAERYAPGFTADTPLPGWSMTKTVTAALVGTLVAQHKLSPDASALLPEWRGSGDPRAAITLDALLRMTSGLQFNEDYDDPLSDVALMLYAQPDTARFASEKPLAATPGTRWSYSSGTSAILARVMREALGSSDGDYLALPRRALFAPLGMRSAVFEPDASGTLVSPSYMYASARDWARFGQLLLQDGVWDGQRLLPEGWVRYLTRTTPQSERQEYGAQLWVKVPEPFNDRDPHAVAMPADAFHAVGHEGQFVSVVPSRQLVVVRLGLSRPESAWNHEAFLARVLDAVPAPGA
>NZ_CP028808.1|WP_039349841.1|2977432_2978056_+|glutathione-S-transferase
MLHILGKIPSINVRKVLWLCTELNLPFEQEDWGAGFRTTNDPAYLALNPNGLVPVIKDDDFVLWESNTIIRYLANRYGGDALYPAEPQARARVDQWIDWQGADLNRSWVGAFLGLVRKSPDHQDPAGIAQSIAGWTKHMQVLNTQLEATGAYVAGNGFTLADIPIGLSVNRWFGTPFEHPDFPAVSRYVERLATREGFQKYAGSANP
>NZ_CP028808.1|WP_039349838.1|2975860_2977360_+|TIGR01777-family-protein
MNTLPAYDWALNLLIVQGAMGAFDTLYHHELTQDLPHSPRAQLELGIHAVRSVLYGLVFASIANVAFHGAWVAAIAAVVVVEVVLTLWDFVVEDQSRKLPATERVLHTLLAVNGGALFGMIAMQLAAWAHEPTALQALDLGWRGWVLSLFAVGVTVSGIRDGIAACRIARRAPVANPFAGQPPGNVLVTGGTGFIGETLVNHLLDAGHTVTLLARDPLRAAYTFHGRVRSVTSVGQLQPHERFDTVINLAGAPVLGARWSKRRRAVLLASRVGVTESLMRWVETAEVKPRTWIQASAIGYYGVRPADERLDESSSAGAGFMSELCRQWEQSARPLERHGVRSVVLRLGVVFGPGGALRPMLLPHYVGMGGRFGDGTQVMSWIHRDDVLRIIARAMANPGMHGVYNAVAPAPLTQREFVQVVSKVLRRPAWLHVPAAPLRIAMGEMAELLLDGQRVMPARLHQDGFMFRFPTAEHALRDLTNRPHADFPCMACRLPRGRV
>NZ_CP028808.1|WP_039349802.1|2974991_2975864_+|DUF393-domain-containing-protein
MRSSELVLYFDGRCPLCVAEIKRLGARDARHRLAFVDIAKPGFDPAPLGVDLPALNRELHARLPDGRMLTGVDSILAAQALTGRRTLVRLLRVPAVRGVLALLYRRFARNRHAVSRWLGYRTEAPCDAAACGSGSERAAEPTPDRPAGGAARRLVVTWMYVAATAHVLVGMAVPWVAGAPWLDAYHRVIELHFWAGAAPDAARAQQVWWMSLMGATVQCASVWMLALVHLGNRLRKREVWGWLLAGLLIWAPQDMLFSLQAHVSGHVAIDAAALVAMVPPLVWLWRRDAV
>NZ_CP028808.1|WP_039349799.1|2974420_2974891_+|DUF2269-domain-containing-protein
MNTYLVIKALHILSSVLLVGTGFGTAFYLFFANRTRSVPAIAAVSRLVVRADWWFTTPAVIFQPASGLWLAHTAGWPWDTPWLVASIVLYAIAGVCWLPVVWLQLELASMAKLAHANGNAALPERYWRYAKRWELLGYPAFFAMLTVYFLMVLKPM
>NZ_CP028808.1|WP_039349797.1|2973116_2974424_+|SDR-family-oxidoreductase
MDTVLPSTRPHGRTRAHSMTVLVCGANGFIGRALCAQLEAGGHRVLRGVRHATGLCDVEIDFAQDIDPDAWLARLEGVDVVINAVGILADQRGATLDAVHRAAPCALFTACCRAGVRRVIQISALGVERGNTRYFASKCAADRFLKTLPIDFRIVRPALVYGTDGASARFFRMLASLPVQVLPAGGHQRLRPVHVDDLAEVVARCVDAPAVGRAVIDVVGADEVEYREMLARYRAALGFPPAARIGLPGPLAGMAAALLGTLPGAIFTRDTWTMLRGGNTGDPAAATAMLGRPPRGIDGFIGAEAAALRRDALAMWRRPLLRGALAIVWIWTAIASAFIHPLHASLALLAPAHLTGLPALIALYAASALDFSFGIATVVAPSRRLWGAQAALIVAYSAVIAVTMPGLLAEPFGPVLKNVPILAILLILFSEEEQA
>NZ_CP028808.1|WP_011353812.1|2972494_2973028_+|MarR-family-transcriptional-regulator
MELTPIAERFILHWGEMGSRWGVNRTVSQIHALLYLAGRPIAADEIAETLNVARSNVSTSLKELQAWRLAKVVHVLGDRRDHFETSTDIWELFKLIVEGRRQREIEPTLTVLRDCLTNPEIANESRETEQRIRDTLQFVETLTTWSDEMLRLKPDTLMKALGIGAKISQTVRRKPSK
>NZ_CP028808.1|WP_039349792.1|2971131_2972334_-|trans-2-enoyl-CoA-reductase-family-protein
MIIKPRVRGFICVTTHPVGCEANVKEQIDYVTSHGPIANGPKKVLVIGASTGYGLAARISAAFGSGADTLGVFFERAGSETKPGTAGWYNSAAFEKFAAEKGRYARSINGDAFSDKVKQVTIDTIKQDLGKVDLVVYSLAAPRRTHPKTGETISSTLKPIGKTVTFRGLDTDKEVIRDVTLEPATQEEIDGTVAVMGGEDWQMWIDALDEAGVLADGAKTTAFTYLGEQITHDIYWNGSIGEAKKDLDKKVLSIRDKLAAHGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKTMKENGTHEGCIEQVYGLFKDSLYGATPHVDAEGRLRADYKELDPQVQAKVVAQWNHVTNENLYELTDFTGYKTEFLRLFGFEIAGVDYDADVNPDVKIPGIIDTTV
>NZ_CP028808.1|WP_039349877.1|2983185_2984022_+|(S)-ureidoglycine-aminohydrolase
MSKTTYYAPHGGHPPQTDLLTDRAMFTEAYAVIPKGVMRDIVTSWLPFWTNTRLWVIARPLSGFAETFSQYIVEVNPGGGSDKPEQDKNAEAVLFVVEGEAELTLQGTKHVLKPGGYAFIPPGADWTLHNVSDAAVRFHWVRKHYQAVDGIPLPEAFVTNEQDVEPIPMPGTNGAWVTTRFVDMSDMRHDMHVNIVTFEPGGVIPFAETHVMEHGLYVLEGKAVYRLNQDWVEVEAGDFMWLRAFCPQACYSGGPGRFRYLLYKDVNRHMNLLLNPAR
>NZ_CP028808.1|WP_039349878.1|2984199_2984574_-|heavy-metal-responsive-transcriptional-regulator
MRIGELCKRAGVSHDTVRYYERMGLLDKATRPHATNTYKHYSERSLQRIRLIIHAKALGFTLTEIGDVIHVWDSPTFGVAQKVACLQAKLTEIDEKSRALVMLRAGLLNALAKVGSDCVEGHIA
>NZ_CP028808.1|WP_046196361.1|2984673_2985501_+|SDR-family-NAD(P)-dependent-oxidoreductase
MRDRFDFHGKTALVTGASSGIGRAFAYALAKRGARLLLVARSRDKLHDLAAELRRDYACDADFLTVDLSTADAVHTIDCHLKVTGKVVDVLVNNAGFAAYGRFETIPWTRQRDEVLVNCMAAIELTHLLLPGMQARSAGAVINVTSTAAFQPDPYMAVYGATKAFLLSFSEAVWAENRHRGIRVVALCPGATQTAFFDVVGAQEAAVGTPMPVASVVEDALWALDRNRSHRIVGTRNRLLANLQRLLSRETSARLVEKILRPRGGQDPVTRETNA
>NZ_CP028808.1|WP_039349880.1|2985578_2986373_-|phosphotransferase
MFDRYLGLWGLVPDGGPLLTASGGLLPVVWQSRPAMLKVATCDEERRGNALMTWWNGQGAAQVWLHDGDAILLERAQPEPTLAGFSASGHDDDAMRIACDVVARLHAHRASEPPSVVALHAWFQALLSDASASVVLHRSATVARQLLAGPPVDEVVLHGDIHHGNILHFGDRGWRAIDPKGLRGDRAFDYANLFCNPSHDVAVDPVRFAQRVTLVASTAQLDRRRLLQWILAWSGLSAVWLIEDELLPDTRLQVATLAAAALGL
>NZ_CP028808.1|WP_039349883.1|2986612_2988733_+|PBP1A-family-penicillin-binding-protein
MTDHTAAPPPPPASPPRRRRVWRTLAGALLGLTVACAGIGAWTIQRIWTQLPSVEHLAVYRPALPLRIFSRDGDLLAEYGVERREFVPLERIPPLMRQALLAAEDAKFYQHGAVDFGGLARATFANVVTGQPGQGGSTITMQVARNFYLTRDKVLSRKLAEILMAAKLEREYSKDKLLELYMNEIYLGERTYGFAAAANVYFGKPLDALSAGEAAVLAGLPKAPSAFNPVVNPARATARRNYVLGRMHALGQLDDATYHAAVDAPIALATTPPPGIIAAPYVAERARRMMVERFHDDAYTLGLDVTTTISMRDQRAAESSLARTLSRQTRAKRDARNGLEGALVSLDAATGDMLALVGGADFNRNVFDHALQAYRQPGSSFKPFVYSAALEKGYFPGVLVDDTQRTLTHEETGARPWRPRNFANNYEGFIPVRRGLMRSKNLVAVSLMQATDARYVQQHAVHFGFDAQRNPASLPLALGAGAVTPLELASAYSVFANGGTRMEPRLILSVKQRHGGAMYEATAPAGERVVSARNAFVMDSMLRDVVKSGTARGALALRRDDAAGKTGTSNGSKDVWFAGYSSGIVAVAWLGYDTPRPMGRATGATLALPVWLDYMKTAVDGRTPVEATPPQDVALVDGDFVYAEYTRGTCTADVPSYIRSRFACGGAAAAGASDAPGNDGKPAESTPAAVDAAERERVLDLFRTDD
>NZ_CP028808.1|WP_039349886.1|2988741_2989353_+|trimeric-intracellular-cation-channel-family-protein
MHTLYLIAIVAEAMSGALMGMRRGMDRFGLALVGAVTALGGGTVRDVLLGHYPLGWIAHPEYLVITLVAATVASWVARHVARMKTLFVTVDAIGLAAFTIIGCDIGASTGSAPIIVVLAGAITGVCGGMLRDLLCNEMPLILREELYACVAFVTGGLYVGMQHLGVDAGIATVAALAAGFSMRMLAVRLGWKMRTFGAADLEH
>NZ_CP028808.1|WP_039349889.1|2989482_2990304_-|heme-ABC-transporter-ATP-binding-protein
MLTAHHLDVARRHHAILRDLSLSIVPGRVTALLGRNGAGKSTLLKTFAGELTGNVAPNGVRVTGDITLNGEPLARIDAPRLACLRAVLPQAAQPAFPFSVDEIVLLGRYPHARRSGATSHRDRDIAWCALERAGADGLVGRDVTTLSGGELARVQFARVLAQLWPDDEATESGPRYLLLDEPTAALDLSHQHRLLETVRAVAREWQLGVLAIVHDPNLAARHADTIALLADGTIVAHGTPRDVMTPSHIAQCYGFAVKMVETGDGAPPVMVPA
>NZ_CP028808.1|WP_039349892.1|2990323_2991412_-|iron-ABC-transporter-permease
MPAHASPFPASSSASRSGAARIGTSRRFAPFALAALACLVCAMSVVALCVGAYRIPLAEAWAALTGDAAAQQARAVLFDIRAPRVALALLVGGGFGATGAAMQALFRNPLADPGLVGVSSGAALGATTMIVLGPALFAAQVSAAALPAAAFAGALAVAALVYRLAASRGRLALPLLLLAGIAINALVGAAIGLLTFIADDAQLRSLTFWSLGSLGGAQWSALAAVAPCVAIGGALLARERDALNALQLGETEALHLGVPVQRLKRRVLVAVALAVGALVSCSGIIGFIGLVAPHCVRLVCGPDQRVVLPGAALFGALLTLAADLAARTVAAPAEVPLGVLTALLGAPFFLALLWKSRGALGG
>NZ_CP028808.1|WP_039349895.1|2991427_2992342_-|ABC-transporter-substrate-binding-protein
MSARPFDPRRRALLASAAAGALAGALPGSVLAQGAQATPKRVVVIGGALAETAFALGGAETPRYRLVGADTTCTYPDAAKRLPKVGYQRALSAEGLLSLRPDLVLASAEAGPPTAIAQVKNAGVAVTTFDERHDVESVRAKITGVAQALDVRDAGAALLQRFDRDWQAARDAVAARARGDAPPRVLFVLNHTGNQALVAGQRTAADAMIRYAGARNAMQGFDHYKPLTTEALAAAAPDVVLISDEGLAAVGGRAALLATPGFGATPAGRAQRVVSLDALFLLGFGPRLPLAVTTLHRRLSDALA
>NZ_CP028808.1|WP_039349897.1|2992338_2993430_-|hemin-degrading-factor
MMQSALPGQPATPARAAAALRDAFIKLKTERQLRNRDVAQALGVSEGEALAAFVGEHVVRLDARFPAMFEEMPRLGRVMALTRNDTAVHEKDGEYAQMSHDGPVGLALGDIDLRIFYRHWVSAFAVRDETAHGPLKSLQFFDAQGHAIHKVYLRAHSDHAAYDAFVERWRAPSQEPGLEVAPAAPKTPERADTEIDVAGFRAAWDAMTDTHQFFGITQRFGVSRMQALRLADPQYAYPVETAHALRHVLQHAAESGQPIMVFVGNAGMIQIHTGPVANVREVGAWINVLDPGFNLHVREDLIAAAWVVKKPTSDGIVTSLELFDRQGDHVALLFGERKPGQVERDDWRALVATLPAAARGGAR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP028808_2	2.3\|2982048\|31\|NZ_CP028808\|CRISPRCasFinder	2982048-2982078	31	NZ_AP014579	Burkholderia sp. RPE67 plasmid p1, complete sequence	37563-37593	6	0.806
NZ_CP028808_2	2.3\|2982048\|31\|NZ_CP028808\|CRISPRCasFinder	2982048-2982078	31	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	1327605-1327635	6	0.806

1. spacer 2.3|2982048|31|NZ_CP028808|CRISPRCasFinder matches to NZ_AP014579 (Burkholderia sp. RPE67 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

gggtggcgcggtgacgtcgaaccgtcacgag	CRISPR spacer
gggtggcgcggtcacgtcgaatcgcagggag	Protospacer
************ ********.**. . ***

2. spacer 2.3|2982048|31|NZ_CP028808|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 6, identity: 0.806

gggtggcgcggtgacgtcgaaccgtcacgag	CRISPR spacer
gggtggcgcggtcacgtcgaatcgcagggag	Protospacer
************ ********.**. . ***

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP028807

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CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP028808

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection