CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP045177	Streptomyces tsukubensis strain AT3 plasmid pST1, complete sequence	0 crisprs	NA	0	0	0	0
NZ_CP045178	Streptomyces tsukubensis strain AT3 chromosome, complete genome	29 crisprs	csa3,casR,cas3,DEDDh,WYL,cas4,Cas9_archaeal,PD-DExK,cas6e,cas5,cas7,cse2gr11,cas8e,DinG	3	18	0	0

1. NZ_CP045178

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP045178_1

• CRISPR_ID: NZ_CP045178_1
• CRISPR_location: 140866-140952
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_1

Consensus_repeat	Method
CGGGACGTCCGCGCGCTCGGGGAGGG	CRISPRCasFinder

spacers of NZ_CP045178_1

>1.1|140892|35|NZ_CP045178|CRISPRCasFinder
AGCGGCCGTGGCACCGGCAGACGGAGAGAGGGGCA

CRISPR arrays and Neighbor proteins around NZ_CP045178_1

CRISPR arrays

The CRISPR arrays of NZ_CP045178_1

>merge|NZ_CP045178|1|140866-140952|CRISPRCasFinder
CGGGACGTCCGCGCGCTCGGGGAGGGAGCGGCCGTGGCACCGGCAGACGGAGAGAGGGGCACGGGACGTCCGCGCGCTCGGGGAGGG

>NZ_CP045178|1|1|140866-140952|CRISPRCasFinder
CGGGACGTCCGCGCGCTCGGGGAGGG	AGCGGCCGTGGCACCGGCAGACGGAGAGAGGGGCA
CGGGACGTCCGCGCGCTCGGGGAGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077973960.1|146084_149285_+|Bacterial-alpha-L-rhamnosidase	unknown	unknown	gnl|CDD|379971
NZ_CP045178.1|WP_143621576.1|150213_150465_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973955.1|136628_137879_-|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|173833
NZ_CP045178.1|WP_152330721.1|130780_132406_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|225885
NZ_CP045178.1|WP_077973948.1|128875_130060_+|lycopene-cyclase	unknown	unknown	gnl|CDD|310433
NZ_CP045178.1|WP_107503056.1|132514_132925_-|RidA-family-protein	unknown	unknown	gnl|CDD|100004
NZ_CP045178.1|WP_077973985.1|144389_145886_-|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224053
NZ_CP045178.1|WP_077973962.1|150439_152872_+|polysaccharide-lyase-8-family-protein	unknown	unknown	gnl|CDD|238517
NZ_CP045178.1|WP_077973949.1|130118_130847_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|225136
NZ_CP045178.1|WP_077973957.1|141154_142243_-|rhamnose-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380655
NZ_CP045178.1|WP_077973958.1|142364_143360_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|119321
NZ_CP045178.1|WP_077973954.1|135090_136632_-|phytoene-desaturase	unknown	unknown	gnl|CDD|274273
NZ_CP045178.1|WP_077973961.1|149578_150088_+|O-acetyl-ADP-ribose-deacetylase	unknown	unknown	gnl|CDD|234759
NZ_CP045178.1|WP_077973986.1|154375_155614_+|deferrochelatase/peroxidase-EfeB	unknown	unknown	gnl|CDD|273606
NZ_CP045178.1|WP_077973956.1|138074_140168_-|MMPL-family-transporter	unknown	unknown	gnl|CDD|225272
NZ_CP045178.1|WP_077973959.1|143352_144393_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224093
NZ_CP045178.1|WP_077973952.1|133073_134093_-|Rieske-2Fe-2S-domain-containing-protein	unknown	unknown	gnl|CDD|334028
NZ_CP045178.1|WP_107503057.1|140337_140757_-|winged-helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
NZ_CP045178.1|WP_077973953.1|134092_135094_-|phytoene/squalene-synthase-family-protein	unknown	unknown	gnl|CDD|173831
NZ_CP045178.1|WP_077973963.1|153134_154361_+|EfeM/EfeO-family-lipoprotein	unknown	unknown	gnl|CDD|271139

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077973960.1|146084_149285_+|Bacterial-alpha-L-rhamnosidase	gnl|CDD|379971	pfam17389, Bac_rhamnosid6H, Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain. This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.	1.05529e-135
NZ_CP045178.1|WP_077973963.1|153134_154361_+|EfeM/EfeO-family-lipoprotein	gnl|CDD|271139	cd14656, Imelysin-like_EfeO, EfeO is a component of the EfeUOB operon. This family includes the EfeO domain, an essential component of the EfeUOB operon which is highly conserved in bacteria. However, its biochemical function is unknown. EfeO contains an N-terminal cupredoxin (CUP)-like domain and C-terminal imelysin-like domain that may bind iron. Algp7, a member of EfeO family protein from Sphingomonas sp. A1, is found to bind alginate at neutral pH, but does not contain the CUP domain, thus having a role that does not seem to be related to iron uptake. Some members of this family are fused to an N-terminal putative EfeU ion permease domain. The imelysin-like domain of this family also contains the GxHxxE sequence motif and a highly conserved functional site, suggesting a similar role to other imelysin family proteins containing the same motif.	7.48083e-74
NZ_CP045178.1|WP_077973955.1|136628_137879_-|polyprenyl-synthetase-family-protein	gnl|CDD|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	1.2237e-71
NZ_CP045178.1|WP_152330721.1|130780_132406_+|FAD-dependent-oxidoreductase	gnl|CDD|225885	COG3349, COG3349, Uncharacterized conserved protein [Function unknown].	1.30986e-36
NZ_CP045178.1|WP_077973948.1|128875_130060_+|lycopene-cyclase	gnl|CDD|310433	pfam05834, Lycopene_cycl, Lycopene cyclase protein. This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclisation of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare.	1.28906e-103
NZ_CP045178.1|WP_107503056.1|132514_132925_-|RidA-family-protein	gnl|CDD|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	6.47921e-17
NZ_CP045178.1|WP_077973985.1|144389_145886_-|sugar-ABC-transporter-ATP-binding-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_CP045178.1|WP_077973962.1|150439_152872_+|polysaccharide-lyase-8-family-protein	gnl|CDD|238517	cd01083, GAG_Lyase, Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. These are broad-specificity glycosaminoglycan lyases which recognize uronyl residues in polysaccharides and cleave their glycosidic bonds via a beta-elimination reaction to form a double bond between C-4 and C-5 of the non-reducing terminal uronyl residues of released products. Substrates include chondroitin, chondroitin 4-sulfate, chondroitin 6-sulfate, and hyaluronic acid. Family members include chondroitin AC lyase, chondroitin abc lyase, xanthan lyase, and hyalurate lyase.	0
NZ_CP045178.1|WP_077973949.1|130118_130847_+|methyltransferase-domain-containing-protein	gnl|CDD|225136	COG2226, UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism].	6.39706e-28
NZ_CP045178.1|WP_077973957.1|141154_142243_-|rhamnose-ABC-transporter-substrate-binding-protein	gnl|CDD|380655	cd20000, PBP1_ABC_rhamnose, rhamnose ABC transporter substrate-binding protein. Rhamnose ABC transporter substrate-binding protein similar to periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium. The members of this group are homologous to a family of periplasmic pentose/hexose sugar-binding proteins that function as the primary receptors for chemotaxis and transporters of many sugar based solutes in bacteria and archaea and that are a member of the type 1 periplasmic binding protein superfamily. LsrB, which is part of the ABC transporter complex LsrABCD, binds a chemically distinct form of the AI-2 signal that lacks boron, in contrast to the Vibrio harveyi AI-2 signaling molecule that has an unusual furanosyl borate diester. Hence, many bacteria coordinate their gene expression according to the local density of their population by producing species specific AI-2. This process of quorum sensing allows LsrB to function as a periplasmic AI-2 binding protein in interspecies signaling.	3.65086e-152
NZ_CP045178.1|WP_077973958.1|142364_143360_-|ABC-transporter-permease	gnl|CDD|119321	cd06579, TM_PBP1_transp_AraH_like, Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.	9.78822e-67
NZ_CP045178.1|WP_077973954.1|135090_136632_-|phytoene-desaturase	gnl|CDD|274273	TIGR02734, Phytoene_desaturase_lycopene-forming, phytoene desaturase. Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_CP045178.1|WP_077973961.1|149578_150088_+|O-acetyl-ADP-ribose-deacetylase	gnl|CDD|234759	PRK00431, PRK00431, ADP-ribose-binding protein.	1.74296e-87
NZ_CP045178.1|WP_077973986.1|154375_155614_+|deferrochelatase/peroxidase-EfeB	gnl|CDD|273606	TIGR01412, Probable_deferrochelatase/peroxidase_EfeN, Tat-translocated enzyme. This model represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Members of this family show homology to Dyp, a dye-decolorizing peroxidase from Geotrichum candidum that lacks any typical heme-binding site.	4.92183e-147
NZ_CP045178.1|WP_077973956.1|138074_140168_-|MMPL-family-transporter	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.28786e-68
NZ_CP045178.1|WP_077973959.1|143352_144393_-|ABC-transporter-permease	gnl|CDD|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	1.4604e-70
NZ_CP045178.1|WP_077973952.1|133073_134093_-|Rieske-2Fe-2S-domain-containing-protein	gnl|CDD|334028	pfam00355, Rieske, Rieske [2Fe-2S] domain. The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilizes the protein.	4.0854e-17
NZ_CP045178.1|WP_107503057.1|140337_140757_-|winged-helix-turn-helix-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	9.05666e-12
NZ_CP045178.1|WP_077973953.1|134092_135094_-|phytoene/squalene-synthase-family-protein	gnl|CDD|173831	cd00683, Trans_IPPS_HH, Trans-Isoprenyl Diphosphate Synthases, head-to-head. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze a head-to-head (HH) (1'-1) condensation reaction. This CD includes squalene and phytoene synthases which catalyze the 1'-1 condensation of two 15-carbon (farnesyl) and 20-carbon (geranylgeranyl) isoprenyl diphosphates, respectively. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DXXXD) located on opposite walls. These residues mediate binding of prenyl phosphates. A two-step reaction has been proposed for squalene synthase (farnesyl-diphosphate farnesyltransferase) in which, two molecules of FPP react to form a stable cyclopropylcarbinyl diphosphate intermediate, and then the intermediate undergoes heterolysis, isomerization, and reduction with NADPH to form squalene, a precursor of cholestrol. The carotenoid biosynthesis enzyme, phytoene synthase (CrtB), catalyzes the condensation reaction of two molecules of geranylgeranyl diphosphate to produce phytoene, a precursor of beta-carotene. These enzymes produce the triterpene and tetraterpene precursors for many diverse sterol and carotenoid end products and are widely distributed among eukareya, bacteria, and archaea.	6.91192e-76

Protein sequences

>NZ_CP045178.1|WP_107503057.1|140337_140757_-|winged-helix-turn-helix-transcriptional-regulator
MNGEINRLVHGFAVRHGLHPTDLQALAAILDADAPLTPGRLREHLGLTSGAVTACLDRLERAGHIHRKRESTDRRVVHLHYAAGARAAGREYFLPLAEATRRARDGFSETELSTVLRFLTSMNEELVGLRAAPRDLPPS
>NZ_CP045178.1|WP_077973956.1|138074_140168_-|MMPL-family-transporter
MSATARLARWLVPVVLLAAWLGVGATLGPFAGRLGEVSTNDQASFLPRNAESTRVIEAQRAFRQKETLPAIVVWTADGSKDGRLGEQRRAAATRTLASLSGSAGTVGEASPAVASEDGRALQGVVQLRPDLGKALPDTLERIRRAANGVAGTTAQVAGPAASQADLSDAFSGIDGILLGVALVAVLVILLLVYRSLLLPLVIILGAVFALGLACAVVYALADHDVVRVDGQVQGILSILVIGATTDYALLLTARFGEELAVRNDRVAAMRAALRRSAGPVTASAATVALGLLALLLSDLTNNRALGPVGAIGIVAAVLSALTFLPAVLVLLGRAAYWPSGLSSAAAKNKGRGVWDRVAALVDRAPRKVWATTLAALVVCAAFAPTLTAKGVPLDEIFVDDAPSVAAQQTLSRHFPGGSGNPVVVIADSSRLAPVTAALESTDGVQSAAPVSATGRPGGRPLVVEGRVRVEATLTDAADSDAAKAAVAGARDAVRAVPGADALVGGYTAQQYDTARTAEHDRLLIAPVVLAIILIILIGLLRSLLMPVLLVATVALNFLATLGVAALVFQHLLGFSGTDSSVPLYGFVFLVALGVDYNIFLMSRVREESVLHGTREGVLRGLTATGGVITSAGVVLAATFSALGVIPLAFLVQIAFIVAFGVLFDTLVVRSLLVPALVRDIGRTAWWPGALSRRPEPR
>NZ_CP045178.1|WP_077973955.1|136628_137879_-|polyprenyl-synthetase-family-protein
MRRERATTRPSGGPSVTALPTAVAVRSRSRDTVDGDVAGAVGQELEEVLRARVGQAASIDPTFTRDVAERVAHFTLHGGKRLRSQFLWWGLRACGGGSEGQTRSALRIAAGLELIQTCALVHDDVMDGSPLRRGRPAVHTDLATQYGPVRAGEGDVSFGAAGAVLVGDLALVWADDTVAETELDTATRLRVREVWRAMRTEMVAGQYLDLHGQATAVRSVSRAVRAARLKTAMYTVERPLALGAALAGADGPTVRALRSAGRCAGIAFQLRDDLLGLFGDPEVTGKPSGDDIRSGKPTYLVAVALARAEATGDQRCRALLEGALGDGDLSEDDLTRIRAALVATGARDLVTAEINRLVARGHRCLNAISMEPRVLRRLGALLRGVTTPPAAPVEHDQRHAPPVSHGLADATPRSDR
>NZ_CP045178.1|WP_077973954.1|135090_136632_-|phytoene-desaturase
MRTLKGPTDHVVVVGAGLSGLSAALHLLGSGRAVTLVERDAVPGGRAGRVEQGGYRFDTGPTVLTMPELIEEAFAAVGETMSAHLDLIPLHPAYRARFADGAELDVHTEADAMTAEVERFAGPREADGYRRLREWLGKLYAVQMRRFIDTNFDSPLSLLHPDLARLAALGGFGRLDPRIGAFISDERLRRVFTFQALYAGVPPAGALAAYAVIAYMDTVAGVYFPRGGMHALPKAMADAAEGAGAVLRYSHDVTRLERSGDRVTAVITDKGRIPCDAVVLTPDLPVAYRLLGRSPRRPVRLRHSPSAVILHAGTDRTWPGLAHHTISFGAAWKSTFEELTRTGHLMSDPSLLITRPTATDPGLAPPGRHLHYVLAPCPNTEVGPGVREWGDLGPRYRDTLLRELEGRGLSGLAGAIEEQCLVTPADWSARGHAAGTPFSAAHTFPQTGPFRPRNLVRGTDNAVLAGCGTTPGVGVPTVLISGKLAAARVTGPPPGHHAGAGAVLDVTPEGSPA
>NZ_CP045178.1|WP_077973953.1|134092_135094_-|phytoene/squalene-synthase-family-protein
MTRRELDAAGITEPALRSAYAHCRRLNASHGKTYFLATRLLPVAHRPAVHALYGFARWADDIVDDLGSGASTAQRAEALATLGRRLDAGLRSGHSREPVVQALAHTAAVYDIDHQYFADFMTSMSDDLAVTDYPTYDDLLGYMHGSAAVIGLQMLPVLGTVVPRAEAAPHAADLGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRELLQWSRATGARDPRVTEALKATAHLIRGVYRRAYPGIAMLTPVSRPCIRTAFVLYGAILDAVADDGYAALHHRAVVPRRRRAAVALDGLARVAAARLKAADPPPPPALVRLGHPTAPHAEAV
>NZ_CP045178.1|WP_077973952.1|133073_134093_-|Rieske-2Fe-2S-domain-containing-protein
MPEDRARRGRYPLRLRRGPTEWERQRPSWREARPVLIAGALKRALARPSGNWYVVGASRDITADRPSGRTVAGVELVLWRDGGGRLHAGPGACPHLGAPLKDSRVHCGTLVCHWHGLALDGAPFPGWDPVPAHDDGVLAWVRLDRAGGEEPLDGPVVPVRPAAAGSVAAVYTGFGTCEPEDVVANRLDPWHGAWLHPYSFVDLTVVSTPAGDRAADPAADGFAVDVSFKVAGRAVVPVRAVFTAPEPRTVVMHITEGEGAGSVVETHATPLAADRQGRPRTAVVEAVVAVSGRPGFALARAAAPALRPLMRTVAGRLWRDDLAYAERRWELRSTGRFPG
>NZ_CP045178.1|WP_107503056.1|132514_132925_-|RidA-family-protein
MPTRITRVNPEQSHETPGYHHITVVEAGRTAYLAGQCPLDRHGALVGADDFDAQADQVAENALSALTAVGALPAHVVRSVIYVRSADRAVLGSVWHRLTDSVIGPAFTTAATLLGVTQLGFTGQLVEVDLTVALPD
>NZ_CP045178.1|WP_152330721.1|130780_132406_+|FAD-dependent-oxidoreductase
MADRHRAHRGRLRAGRRGRPPVTRARHTSAGVPRRGLDRRAEIVAPAPGRARITGSAPRVAVVGGGIAGLAAATGLVERGVRVTLHESEPVLGGRLAGRPVRLADGSAVTMSRGFHAFFRQYYNLRGLLRRADPALGMLTGLADYPLRHSGGMYDSFARVPRTPPWSALGFVALSPTFGWRDLSRMDPVAALPLLDVRVPRTYERLDGVSAWEFLSRVGFPEAAHHLAFEVFSRSFFSDPRELSAAELVLMFHIYFLGSSEGLLFDVPNEPFPQALWDPLGDYLKDRGAELRTGTSVEEVSPVGDGLTVRADGRERTYDAVVLALDSGGLRRLVAASPRLGDAVWRERVGRLRSAPPFLVARLWLDRPVARDRPGFLGTSGFGGLDNVSVLERWEGEAARWSARTGGSVIELHAYAVAPGADRAGEQRSLVDQLHRVYPETREARIVDECHEWREDCPLFPVGGYEDRPTVATPHPSVMVAGDLVRTELPVALMERAATTGFLAANALLRRWGVRGQTLWTVPRRGRSAALRAVSRLGAGG
>NZ_CP045178.1|WP_077973949.1|130118_130847_+|methyltransferase-domain-containing-protein
MTLLRDQELSAAFDHASPAYDRLVAVNPGYHSHLRRSARRLGLPDGGAGLRLLDLGCGTGASTSALLSAAPHAEIVAVDASAGMLERALAKRWPRNVSFVHSPVEELAEAGVTGPFDAAFAAYLFHNVTDTDRPLSAVRSLLAPGGRLGVHEYTLSGRSMDLAVWNAVCRGVLIPVGGLTGDAGLYRHLWRSVVEFDSVRAFRDRVGRAGFRDVRVLPMPGWQTGIVHTVVGCVPDAGDGLR
>NZ_CP045178.1|WP_077973948.1|128875_130060_+|lycopene-cyclase
MHDTDITIVGAGAAGLSLAHRLRSRPGAAALPRVTLVEAPEGGLRPPERTWCFWERPGGEYDGALTASWGSLRVRGPDGSEVVGRPDPFRYKMLRSGAFEALLSRGAGAPHRVEAVVDGVRDIPGGAEVTGTYEDGRALALRSRWVFDSRPPPVLPPARTTLLQHFKGWFVRCEQPVFDPAAADLMDFRTPQPPHGLSFGYVLPTGPREALVEYTEFSGAALDDAAYDRALGHYVRDVLGVGRYTVADTEHGVIPMTDGSFPRRTGASVFRIGAGGGATRPSTGYTFAAIQRQTRAIASAHAAGRVPVPPASHSRRARAMDAVLLRGLDSGRVDGAEFFTRLFQRVPMERLLRFLDGQTGMGEDLRIGLHTPVSAMLRTAAELPLLPRRRPRAR
>NZ_CP045178.1|WP_077973957.1|141154_142243_-|rhamnose-ABC-transporter-substrate-binding-protein
MFSPALRRAGVALAVVTSLALAGTACGGTTKKSVDESAGGGADNSASEADPKAPLKKGLTVAFLPKQVNNPYFTVADKGGEKALGGLGSKYKETGPNNATDTSGQVSYVNTLTQQQVDAMAVSAQDPGALCTALKQAMRNGVKVVTFDSDTNTECRDVFVSQASAEALGRSQVRLIGKQLGYKGDIAILSAAQTATNQNTWITYMKDELKKPKYKNMKLVKTAYGNDDAQMSFQQTQGLLQEHPDLAGVICPTTVGIKAAAQYLSGSKYRGKVKLTGLGTPNDMRQYVKNGTVEAFELWDPAKLGALSAHTAVALASGRITGKKGETFTAGDLGSFTIGDDSVVSLGDPTVFDAKNIGRYKF
>NZ_CP045178.1|WP_077973958.1|142364_143360_-|ABC-transporter-permease
MADISAHRAIRWDTAVGGLLVVLLLLSFSLVDGFGNALNLSFLIGNTLPIALLALPMTMLVVAGEIDLSVASTAGLSGAVMGALWNAGMSIETIIPVCLLIGVVCGLVNGLLVTRLGLPSLAVTIGTMAAYRGIAQIVLGSDAVTDFPSSYLDFAAGKLGDTFIPYAFLPFLVLLAIAVVSLHATPLGRALFATGANEEAARFAGIRVKRHKLWLFVATGLMAALTGIFWALHYASARYDNATGLELSVVAAVLLGGVDFDGGKGTLGGAIAGVFLLGTGQNAMSLLNVSAQSQIVVTGVLLVLSVLAPRVARRFAVARAGRGAAGRTSEP
>NZ_CP045178.1|WP_077973959.1|143352_144393_-|ABC-transporter-permease
MTVTAPPPAPAVDPAKAGATRLVDRVFKMRELAILLVFLVMIAVTQAGNSEFLSEQGIKDLLLNATILVLVASGQALVVITRNVDLSVGSTMGVTAFAAGTYLQGGGPPVVAIVLSVALGIGCGLLNGSLVSLGQVPALVVTLGTLYIIRGLDSVWVGSRQITAADLPDGFVDFGSGGILAVPYLALIALVVLVGVAYYLRHYRGGRELYALGSQPRAARLAGIPVRRRILTAYTACGALAGLAGALYLARFGNVDSSTGNGYELTVVSAVVVGGVAFTGGSGSLYGAALGALLLTSINSVLPALGVSSVWVLAINGVLLVLAIAVDRVVALRLARTLKKRNAGHG
>NZ_CP045178.1|WP_077973985.1|144389_145886_-|sugar-ABC-transporter-ATP-binding-protein
MREPPVLAVRSLTKSFGAVRALQDVSLRLHAGEAHALAGENGAGKSTLIKTLAGVHRPDGGTLVLDGEPVVFNGPADARDAGIAVIYQEPTLFPDLSVAENIFMGRQPVRSLRRVDHKAVRAATAALFARLGVDLDPDQPARGLSIADQQIVEIAKALSLDARVLIMDEPTAALTGSEVARLFGVVRSLREQGAAVLFISHRLEEMFTLCQQVTILRDGALVSSEPLSGLTEDDLVRRMVGRDLDALYPKLDTERGAVALSVRRLTREGVFTDVSFEVRRGEIVGLAGLVGAGRSEVARAVFGVDRRDAGEVRVGGKALTNGAPSVAMAAGLALVPEDRRAQGLVMDMSIERNIGLTGLRSTVRAGLMDRGAERRRSLDWAVKLQVKYARIADAVATLSGGNQQKVVLAKWLATRPDVLIVDEPTRGIDVGTKAEVHRLLSQLASEGVAVLMISSDLPEILGMADRVLVMHEGRITAEIPRAEATEESVMAAATGRAA
>NZ_CP045178.1|WP_077973960.1|146084_149285_+|Bacterial-alpha-L-rhamnosidase
MISRRRLLSTTATALGTSLVAGALPTAARAAGTGEATGRAVRVDRPTVEYVSRPLGISTERPRLSWPLVSTASGQAQRAYQVRVATAQRLLDRPDVWDSGKVASSDSLLVPYRGPELRSRTRYYWSVRVWDTGGKVSAWSTPSWWETGLGDASDWKARWIAAPTALVGAPALDMASWIWFPEGDPASNAPAGTRWFRGTFDVPEGLTAARLVMTADDGCTAYLDGERVLHADADAAGNGWSRPAVADVTRRLDSGPHTLAVEAVNAGESPAGLLGALELTTPEGLQTFNTGDGWRASDKKPADGWEKAGYDDAGWPAAEVVAAWGSGPWGKVSAAHSPVAQLRHAFRLKGKGVARARLYATALGLYEARLNGRRVGEDCLAPGWTDYAKRVQYQTYDVTDLLRPGANALGVELAVGWYAGNVGMFGPHQYGDHPSVLAQLEVTYRDGTTERVLSDTDWKAATGPLTQADLLSGEVYDARLETEGWLRAGFDDSGWASAVAGEKVTAELVAEVDGPCRVERELKTRKVTEPKPGVFVFDLGQNMVGATRLTVSGAAGTTVRLRHAEVLNPDGTVYTTNLRTARATDTYTLKGGGKETYEPRFTFHGFRYVEVTGYPGKPSPDAIVGRVIHTDAPFTMEFETDVPILNQLHSNITWGQRGNFLSVPTDTPARDERLGWTGDINVFAPTATYTMESARFLTKWLRDLRDEQTSEGAFTDVAPQAGALGSGSAGWGDAGVTVPWALYQAYGDTQVLDRSWGSMLKWLDYLEAHSSGRLRPAEGYGDWLNIADDTPKDVIATAYYAHSADLVARTAKVLGKDPAPYVSLFGEVRDAFRAAYVGTDGKVKGDNQTSYVLALSMDLLSDSERRSAADRLVALIEAKDWHLSTGFLGTPRLLPVLTDTGHTDVAYRLLLQKTFPSWGYQIDKGATTMWERWDSIKPDGSFQDAGMNSFNHYAYGCVGEWMYANIAGIAPAAPGFRKVTVRPRPGGGITRAEGRFDARYGAITTAWRKDGDRFRLDVTLPVNTTGEVWIPAGRAADVSHGSATYLRMEDGCAVFAAGSGTFRFSV
>NZ_CP045178.1|WP_077973961.1|149578_150088_+|O-acetyl-ADP-ribose-deacetylase
MTTITVVKGDITEQHVDAVVNAANSSLLGGGGVDGAIHRRGGPEILAACRELRASHYGKGLPTGKAVATTAGELPARWVIHTVGPVHSGSEDRSALLASCYRESLAEADALGAASVAFPAISTGVYRWPLDDGARIAVETVRAARSAVQEVRFVLFDDRAYEAFDALVR
>NZ_CP045178.1|WP_143621576.1|150213_150465_-|hypothetical-protein
MRCEGDGDTAGSSGGVVSGVRCAGAAARARGAAPGHRAPDAAGRAGGGRGRPRPPTRPLTGTTQHVSGFSPTARGPGIFLFLT
>NZ_CP045178.1|WP_077973962.1|150439_152872_+|polysaccharide-lyase-8-family-protein
MSPSPSHLNRRTLLAAGAAAALVPAVTGAGPAEAASGPAGSAPAAEGPYETLLARAARLLVGDDFDPADPDFAPALAALEKTATDLWTRLDRSASRTALWEDLSPVTAEGNFGQSYTRLRTVATAWATPGTSLSGSAEVSKALVAALRLLGERAYHAQAKETGNWWFWEIGAPRALLDTCVLLRGALPAADLAAWLATVDRFCADPDRRTNSPGLAETGANRSDKCVIVALRGLLGGEAAKLVLARDGMSDVRDSGRNSLLRYVESGDGFYEDGSFVQHDAVAYTGSYGSVMLGGAAQLIALLAGSEWAVTDPKVSVVYEAVERCFVPVVFDGLMMDALRGRAVSRQRETDAAAGGAVISGVLLLAESAPAELARKWRATVKGWLRRDDSGRALAQAGIAQVARVKALLADDAVPAAGRTSGHTVFADMDRVVHRRPGWALALSLSSRRIAAYEAGNGENLHGWYTGDGMTYLYAGDGYGQFGDGFWPTVDPYRLPGTTVDTRARSDAGTGAGTGLYRPSNQVAGGAVLEDRFGVSAMELIGEGSSLRAKKAWFTLDNAVVALGAGISATDGRTIETTVENRVTGAGGSHRLLVDAVPQPAREGWSRRFDRLGWAHVEGVGGYVFPAAGDGLRALREDRTGSWRDIDTGADTGGDASALTRRYLTLWFDHGVSPTDASYAYVLLPGASAAATAGWQLSRPVRIVVNSPQAQAVEVRRYGLTAAHFWQAGSAAGIECDGPASVLVRRDGRGASVAVADSGRTGERVTVRLPFPVRSVTSADETVSVTVGRRPTVTVTVGGSRGHTHQAVLA
>NZ_CP045178.1|WP_077973963.1|153134_154361_+|EfeM/EfeO-family-lipoprotein
MAEGQAPPVKGGRRRRRAVAIGAAVAAVCVAGAVVFLTATPDPARQRASGDGLPHTTVEVSTGGCGKGWDRPKGGAQVFDLHSTLNRAAEVYLTDTRTGAVHGEVEGLAPGTSRPLSVTLGNGTYAFRCLPDDVDALTGPTVRVTGAPGPGGPAVAPVNQHDLIPPTISYQKWVGRRMNGLVSAVGELREAIERSDLRAARSRWLTAHLDYERMGAAYGAFGDADGAINGTDAGLAEGVDDVRFTGFHRLEHGLWHGESATELRPVAARLAKDVRGLRDDWGEQRMDPLDLGLRAHEILENTLQFELTARTDFGSGTNLATARANLDGTRTVLRFLRPLLTSRDHDLPLLTSWLDRTETSLDAQHRHGTWTPLDRLDRRARARVDADLGRTVELLADVAAVCDVRRTT
>NZ_CP045178.1|WP_077973986.1|154375_155614_+|deferrochelatase/peroxidase-EfeB
MNGRQGAGAPRGRRTASTRRGFLRGTAVVGAGLVAGDAAGGAAAASATPRVPFHGAHQTAILTPPRPASAFVSFDVTAENRGELADLLRTVTTRARFLTAGGPPPSAGITAPPTDSGTLGPEVPADGLTVTVAAGASLFDDRFGLAKARPRRLVTMEPFADDDLDPDQCHGDLSVQFCARRQDTVLHALRDVARHTRGGMRARWRVDGFSGAPRPSGTPRNHMGFKDGTANPDTADRREMDRLVWAGDDEPAWASGGSYQAVRLIRMLVEFWDRVSLTEQERMFGRRRDNGAPLDGSHEHDEPHYAQDPKGDVIPLDSHIRTANPRTATTEGRRILRRSYNYDRGLDSNGNLDMGLLFCCYQRDLERQFVTVQKSLAGEPLTDYISPFGGGYFFALPGVRNQHDWLGRALLS

Crispr_ID: NZ_CP045178_2

• CRISPR_ID: NZ_CP045178_2
• CRISPR_location: 1081042-1081292
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: casR

Consensus repeat of NZ_CP045178_2

Consensus_repeat	Method
CCGACGCGCCCGAAGTCGGGACCTGGCCGTACCCAGCGCCCGGGTCGAGACCTGACTC	PILER-CR

spacers of NZ_CP045178_2

>2.1|1081100|42|NZ_CP045178|PILER-CR
TGCCCAGCGGCCCGGGGCGGGGCCCGACCATCCCAGCAGCCG
>2.2|1081200|65|NZ_CP045178|PILER-CR
CACAGCGGAACCGTCCCCGTCGAGCGCGACCGCAGGTACCTGAGGCAGGGCCTGGCCGACCGTGC

CRISPR arrays and Neighbor proteins around NZ_CP045178_2

CRISPR arrays

The CRISPR arrays of NZ_CP045178_2

>merge|NZ_CP045178|2|1081042-1081292|PILER-CR
CCGACGCGCCCGAAGTCGGGACCTGGCCGTACCCAGCGCCCGGGTCGAGACCTGACTCTGCCCAGCGGCCCGGGGCGGGGCCCGACCATCCCAGCAGCCGAGGCGGGACCCGGCCGTACCCAGCGCCCCACAGCGGAACCGTCCCCGTCGAGCGCGACCGCAGGTACCTGAGGCAGGGCCTGGCCGACCGTGCCCGACGCGCCCGAAGTCGGGACCTGGCCGTACCCAGCGCCCGGGTCGAGACCTGACTC

>NZ_CP045178|2|1|1081042-1081292|PILER-CR
CCGACGCGCCCGAAGTCGGGACCTGGCCGTACCCAGCGCCCGGGTCGAGACCTGACTC	TGCCCAGCGGCCCGGGGCGGGGCCCGACCATCCCAGCAGCCG
AGGCGGGACCCGGCCGTACCCAGCGCCCCACAGCGGAACCGTCCCCGTCGAGCGCGAC	CGCAGGTACCTGAGGCAGGGCCTGGCCGACCGTGCCCGACGCGCCCGAAGTCGGGACCTGGCCGT
ACCCAGCGCCCGGGTCGAGACCTGACTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077974397.1|1082011_1082815_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|380379
NZ_CP045178.1|WP_077974167.1|1078574_1079351_+|LamB/YcsF-family-protein	unknown	unknown	gnl|CDD|377121
NZ_CP045178.1|WP_077974409.1|1090898_1091666_+|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl|CDD|176504
NZ_CP045178.1|WP_077974404.1|1086469_1086664_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077974175.1|1063967_1064864_+|IclR-family-transcriptional-regulator	casR	cls001593_casR_CAS-I	gnl|CDD|224332
NZ_CP045178.1|WP_077974432.1|1090293_1090902_+|hypothetical-protein	unknown	unknown	gnl|CDD|225239
NZ_CP045178.1|WP_077974171.1|1069431_1070568_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	unknown	unknown	gnl|CDD|176893
NZ_CP045178.1|WP_077974191.1|1079365_1080022_+|5-oxoprolinase-subunit-PxpB	unknown	unknown	gnl|CDD|214820
NZ_CP045178.1|WP_077974402.1|1085705_1086098_-|ankyrin-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|293786
NZ_CP045178.1|WP_077974398.1|1082907_1083714_+|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
NZ_CP045178.1|WP_077974400.1|1083981_1085400_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077974166.1|1080018_1080906_+|biotin-dependent-carboxyltransferase-family-protein	unknown	unknown	gnl|CDD|376868
NZ_CP045178.1|WP_107503071.1|1075535_1076357_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077974410.1|1091732_1093091_+|MFS-transporter	unknown	unknown	gnl|CDD|341035
NZ_CP045178.1|WP_077974407.1|1088504_1090019_-|PLP-dependent-aminotransferase-family-protein	unknown	unknown	gnl|CDD|224089
NZ_CP045178.1|WP_077974406.1|1086770_1088456_+|hypothetical-protein	unknown	unknown	gnl|CDD|274760
NZ_CP045178.1|WP_077974170.1|1070604_1075278_-|hypothetical-protein	unknown	unknown	gnl|CDD|274256
NZ_CP045178.1|WP_077974172.1|1066578_1069104_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|223481
NZ_CP045178.1|WP_077974174.1|1065101_1066187_+|S-(hydroxymethyl)mycothiol-dehydrogenase	unknown	unknown	gnl|CDD|132492
NZ_CP045178.1|WP_077974168.1|1076580_1078110_-|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP045178.1|WP_077974175.1|1063967_1064864_+|IclR-family-transcriptional-regulator	casR	cls001593_casR_CAS-I	3.4e-11	37.5	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077974397.1|1082011_1082815_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	1.42289e-35
NZ_CP045178.1|WP_077974167.1|1078574_1079351_+|LamB/YcsF-family-protein	gnl|CDD|377121	pfam03746, LamB_YcsF, LamB/YcsF family. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression. The exact molecular function of the proteins in this family is unknown.	5.53896e-135
NZ_CP045178.1|WP_077974409.1|1090898_1091666_+|glycerophosphodiester-phosphodiesterase	gnl|CDD|176504	cd08561, GDPD_cytoplasmic_ScUgpQ2_like, Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized cytoplasmic phosphodiesterases which predominantly exist in bacteria. The prototype of this family is a putative cytoplasmic phosphodiesterase encoded by gene ulpQ2 (SCO1419) in the Streptomyces coelicolor genome. It is distantly related to the Escherichia coli cytoplasmic phosphodiesterases UgpQ that catalyzes the hydrolysis of glycerophosphodiesters at the inner side of the cytoplasmic membrane to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.	1.83195e-88
NZ_CP045178.1|WP_077974175.1|1063967_1064864_+|IclR-family-transcriptional-regulator	gnl|CDD|224332	COG1414, IclR, Transcriptional regulator [Transcription].	4.29079e-66
NZ_CP045178.1|WP_077974432.1|1090293_1090902_+|hypothetical-protein	gnl|CDD|225239	COG2364, COG2364, Predicted membrane protein [Function unknown].	1.77177e-40
NZ_CP045178.1|WP_077974171.1|1069431_1070568_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha	gnl|CDD|176893	cd08884, RHO_alpha_C_GbcA-like, C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases. C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. GbcA is involved in glycine betaine (GB) catabolism in Pseudomonas aeruginosa; it may remove a methyl group from GB via a dioxygenase mechanism, producing dimethylglycine and formaldehyde. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.	3.21988e-71
NZ_CP045178.1|WP_077974191.1|1079365_1080022_+|5-oxoprolinase-subunit-PxpB	gnl|CDD|214820	smart00796, AHS1, Allophanate hydrolase subunit 1. This domain represents subunit 1 of allophanate hydrolase (AHS1).	2.74446e-68
NZ_CP045178.1|WP_077974402.1|1085705_1086098_-|ankyrin-repeat-domain-containing-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	6.10879e-16
NZ_CP045178.1|WP_077974398.1|1082907_1083714_+|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	3.6274e-16
NZ_CP045178.1|WP_077974166.1|1080018_1080906_+|biotin-dependent-carboxyltransferase-family-protein	gnl|CDD|376868	pfam02626, CT_A_B, Carboxyltransferase domain, subdomain A and B. Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the A and B subdomains of the CT domain. This domain covers the whole length of KipA (kinase A) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.	1.7209e-107
NZ_CP045178.1|WP_077974410.1|1091732_1093091_+|MFS-transporter	gnl|CDD|341035	cd17482, MFS_YxiO_like, Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily. This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.04272e-146
NZ_CP045178.1|WP_077974407.1|1088504_1090019_-|PLP-dependent-aminotransferase-family-protein	gnl|CDD|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.99037e-94
NZ_CP045178.1|WP_077974406.1|1086770_1088456_+|hypothetical-protein	gnl|CDD|274760	TIGR03743, SXT_TraD, conjugative coupling factor TraD, SXT/TOL subfamily. Members of this protein family are the putative conjugative coupling factor, TraD (or TraG), rather distantly related to the well-characterized TraD of the F plasmid. Members are associated with conjugative-transposon-like mobile genetic elements of the class that includes SXT, an antibiotic resistance transfer element in some Vibrio cholerae strains. [Mobile and extrachromosomal element functions, Other].	0.00242218
NZ_CP045178.1|WP_077974170.1|1070604_1075278_-|hypothetical-protein	gnl|CDD|274256	TIGR02680, conserved_hypothetical_protein, TIGR02680 family protein. Members of this protein family belong to a conserved gene four-gene neighborhood found sporadically in a phylogenetically broad range of bacteria: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria). Proteins in this family average over 1400 amino acids in length. [Hypothetical proteins, Conserved].	2.3435e-11
NZ_CP045178.1|WP_077974172.1|1066578_1069104_+|FAD-dependent-oxidoreductase	gnl|CDD|223481	COG0404, GcvT, Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism].	1.43004e-104
NZ_CP045178.1|WP_077974174.1|1065101_1066187_+|S-(hydroxymethyl)mycothiol-dehydrogenase	gnl|CDD|132492	TIGR03451, S-hydroxymethylmycothiol_dehydrogenase, S-(hydroxymethyl)mycothiol dehydrogenase. Members of this protein family are mycothiol-dependent formaldehyde dehydrogenase (EC 1.2.1.66). This protein is found, so far, only in the Actinobacteria (Mycobacterium sp., Streptomyces sp., Corynebacterium sp., and related species), where mycothione replaces glutathione. [Cellular processes, Detoxification].	0

Protein sequences

>NZ_CP045178.1|WP_077974166.1|1080018_1080906_+|biotin-dependent-carboxyltransferase-family-protein
MTGRALVVVRAGALTTVQDEGRPGHAHLGVPRSGALDLPAARLVNRLAGNAPDAAVLETTLNGCAVRVSETATVVVGGAACAVTVDGRPVPWGAPVRVPAGSVLDVGPAASGVRAYVALGGGVTVERVLGSRSTDLLSGLGPAPLADGAVLPLGPEPSDRPRVDVAPQPGAPRELVLRTRLGPRADRFTEAAPRTLATGAYRVSAASNRIGLRTEGPALAHASTAELPSEGMVLGAVQVPPDGLPVVFLADHPTTGGYPVIGVVHEADLAAAAQAPPGTPLRFAPWKERGGARRG
>NZ_CP045178.1|WP_077974191.1|1079365_1080022_+|5-oxoprolinase-subunit-PxpB
MRTRAVGEHALLVETGGAEATFALHAELIRRREAGSLPPVRDIVPAAATVLLDGVADPGSLAAALVTWRIPPAPRSTGARVELPVRYEGPDLAEVATVWGVSPDEVVRVHTATEFRVAFCGFAPGFGYLTGLGDEHAVPRRSTPRTAVPAGSVGLAGAYTGVYPRSSPGGWQLIGTTSAVLWDVDREPAALLAPGTRVRFVAVTDTADHRDVLGKGPR
>NZ_CP045178.1|WP_077974167.1|1078574_1079351_+|LamB/YcsF-family-protein
MPPVPAPASIDLNADLGEGFGRWRLTDDERLLSVVTSANVACGFHAGDPVTMRRVCERAVEAGVRIGAQVSYRDLAGFGRRAMDVPPAELAAEVAYQIGALEIFARAAGSRVAYVKPHGALYNRVVRDEEQARAVVDGVLLAGAGLPVLGLPGSRLLDIADEAGLPVVPEAFGDRAYTASGTLVPRSSEGAVITDPDTVVERSVGMARSGTVLARSGERIGVRARSLCLHGDTPDAVGLARRVRAKLEAAGVRVEAFA
>NZ_CP045178.1|WP_077974168.1|1076580_1078110_-|hypothetical-protein
MTSPASSDIAPPQLSVGPRPAPGPAADEGLARRLRALACTAPLHDLDVRKANLAGEYSGYAMAEVALAAIDLVTLNMDFDTGADHEQIVARLLPRVAAQASGRPSVEHERVARWVLENLINVGSVDRGFRAVYGTFASDGSYVRRDYDFKLIEEVPGHGGSVYLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLISRGRLADAQLAAEQARYRTVQYSETLRRALDATRRNVRAVDWLTTVPDMIAEALDHVADRYRHENAILTNIRKARDESEDPEQKRRAAELVDIVKDCIRRHTLLQSRLLEAGPLFRAEQDRQAFAAPSGHTSLDLYGQLLAPVLPLPMEQATRVTDAFFARGTGLRTPVSVRVGDLVDILLTPPQEREHLGVEMPDPDLIATPDDSRFSEDQLADAMDLLDLEYDAPRRLSGLLAEARLRDRELPYLIALLAVHAASPPVGTAHRQGEPKLLFAVDDGVELHDEEFGGADLIVGTALLEAAGAATPGRRERT
>NZ_CP045178.1|WP_107503071.1|1075535_1076357_-|hypothetical-protein
MVTPADTADAARLVGFGLQPKLQPARDAEYAELLRRYREDPPFARLADAVATGLGLIILEVSPRAGMAVTASEDSVFAVRMGDYARRASADSADRFLHGLAHLSVAALAFPRPEDLADDGYIGRVTVNGVDAFVRQACRRIEERAETDGENTDPTTGAPGLEAAWRVWARRSSTGATKDARRLAGSTTGIVAKAVAFLTESGFLQRTGDESGGTYRTTARYQLQVRDMAGGAAMAELLELGIVPVTDGSATLLPPDEADDLDLVADAGLPFHS
>NZ_CP045178.1|WP_077974170.1|1070604_1075278_-|hypothetical-protein
MYELSRVRLYSIGPAGARYADTVLDLRGVGQAVPEPAPTQAEFFEDEPIGPPRRPAPAGVLFLENGGGKSVLLKLIFSVMLPGHRNTLGGASSGVLRKFLLAEDCGHVALEWQHTRTGEYVVVGKVSEWRGRQVSNDPRKFAEAWYSFRPGPGMSLDALPVAEATGVRPVAEGASAARGRRRTMKGFRDALTEAGKFYAHLDVHWEETHERWTEHLGELNLDPELFRYQREMNADEGEAAGLFAVKKDSDFTDLLLRAVTDTRDTDGLADLVHGFGNKLGRRAELIAERDFTAGSVDLLGRIVDATVHRGRAREVHTAAERRTRTLARRLTARAGQERERAGDLARQVTDASRSAAEAEGTRGRSALIAAELAYRHASLALTAAEKAAAAQRRELADARTLHSAWQAAEAVLRHRASADRSARVSVAIREAERDAAPALAARAAAAADLVRALHTAAENGERHANEEEERSAVLQEQGEAAHRDATAAATDSQRARSEAGHLRQRLAEVEQETADAVAAGWLDDTAPDADPARAALAASDAEKTAVAAWDAARETSGRAADRAKETASAEARAELSSARAADAATAAERAYDAERSAAASLAAEERLAELLSLPSTPGPAGVPGPRRSGPAPDGAARATSTAGTTTETRLGTEGPLTAPELDGAADGLRDMLEEAVASAERHLFDLRTVAADDSRILGALGDGGLLPPGPDVLTTVEFLGEHGIPALPGWRYLAQAVDPADHAAVLAARPELVDGVVITDPDTHSRAREVLTGAALLPRSTVAVGTAAALLAPTPGQGATETGVFLVPPNPAMHDEHAADEERAQLRTRAAARDEEIRGLAARLAKDRELAARLTSWRAGCPTGHLTELEHTARRAREEAEAAAERLAEARALRTEADEAAAEAAALRDERQETAQRARRVADVLAGLAHRLRERAAWTSRLRELGEEAVESEARAQTCLERARAADEDRRAAQRAADDARRTARALRAERAEIAGAPEELPEPDPEAPRTALPTLREAYRAASQLYEKVGVGADLRAEQARAESDESAARAELDRLSNKVRTRAAQLLEGPDGADGPSRQAAAGRAEELVQKLETRAQSASEQLGRLRGEAERHAPEEGGAHTDLAEELAPRDAEHAQSLLRTATGDLAARTDALATARAAHSELSYAHRAAEEATAGFEETAALLRDLLREPQPGDDGEPAEAPEPYPGTLEEARQSAAETRRSLRGCATDLSTAEAAVREASDILVRHANSTRYEQVRTPARQQIRELPAATLPEHAGKWADAFAPRLRVLTDELEQLERNRDSIVDRLRGLVESSLATLRSAQRLSRLPEGLGEWSGQEFLRIRFEEPDQATLAERLGEVIDEATRSAVRKNSDLRRDGMSLLLRGVQAALQPRGVAVEILKPDAVLRAERVPVGQMGDVFSGGQLLTAAIALYCTMAALRSNDRGRDKHRHAGTLFLDNPIGRANATYLLELQRAVADALGVQLLYTTGLFDTTALAEFPLVIRLRNDADLRAGLKYIRVEEHLRPGLPQQDPEEETVHGEITATRMYKRPS
>NZ_CP045178.1|WP_077974171.1|1069431_1070568_+|aromatic-ring-hydroxylating-dioxygenase-subunit-alpha
MTTAPLSHTSLPQSLHPTLPGHYYTDPEIFRREQEHVFETHWICAVRSADLAKPGAFRTAQVGRESVLVVRGRDGALRAFLNICRHRGARLCMEPRGEVRRALQCPYHAWTYGLDGRLSAAPGLTGMPDVDRSGYGLIPVALREWLGYAWVCTADEPPSFEETVVGAAVERLGDAASIERYRTEDLALGERVTYDVRANWKLIVENFMECYHCATIHPELTDVLPEFTDGFAAQYYVGHGARFAEEAEGFTVDGSAGFGTLPGVGPEQDRRYYAITVRPTVFVNLVPDHVILHRMYPMAEDRTVVECDWLYAPEVLESGADVSKSVELFHRVNSQDFEACERTQPAMSSRAYRAGGVLVPTEHHIGAFHTWLTERLGD
>NZ_CP045178.1|WP_077974172.1|1066578_1069104_+|FAD-dependent-oxidoreductase
MFPEPATSFPASGPRVVVIGAGIVGCCLADELTERGWTDVTVLDQGPLPAPGGSTSHAPGLVFRTSPSKTLTDLASYTVEKFGALSVEGLPCFDAVGGLELATTPERWADLHRKAGLAASWGVEGELVGAARCKELWPLLDEGAVLGGFLTPGDGIAHAVRACRALRERAEGRGARFLGRHTVTGVERADGRVTGVVTDLGSFPADHVVSAAGFWGPVVGRMAGVDVPLLPLAHQYARTAPLPALSEGGGPVPRPILRFQDRDLYFREHQDSEHGDREHGSSEHGDREHGSRLGIGSYAHRPLPVDPFTVPSFDESESMPSSYPFTPEDFAPSWEDCRALLPALEDSEVTEGFNGVFSFTPDGMPLLGQSRELRGFWLAEAVWVTHSAGVGRAVAEWMVDGRPGRDVHGCDLTRFEDAQRSPAFVMERGARQFVEVYDVVHPLQPSGRPRPLRVSPFHARQRELGAVFLESGGWERPHWYEANAGLVVPGEVPERDEWSGRYWSPVASAEARATREKVALHDMTSLRRLEVTGAGALDFLQWMTTNNLAKKPGSVTYTLMLDEGGGVLSDLTVARLGADRFQVGANTPADLERLVRYAPPGVQVRDITSGTCGIGVWGPLARQLVQPLTGEDFSHEGFGYFKGKRAYIGEVPVTALRLSYVGELGWELYTTADLGLRLWDTLWEAGQRLGVVAAGRSAFNSLRLEKGYRSWGQDMTSEHDPYEAGVGFAVRMDRGDFVGRAALEAKAVGGAPRRRLTPLLLDDPAAVVLGGEPVFTPGEPRAAGYVTSASYGYTLGRCVAYAWLPPRETGTAVHVEYFGEKIPATVAREPLFDPEMTKIRR
>NZ_CP045178.1|WP_077974174.1|1065101_1066187_+|S-(hydroxymethyl)mycothiol-dehydrogenase
MSHEVPAVVALKKGAPVEITTIVVPDPGPGEVLVSVQACGVCHTDLHYREGAVGDSFPYLLGHEAAGTVETVGAGVDDLSPGDTVVLAWRAPCGGCRSCRRGRPWYCFDSRNATRPMTLLDGTPLTPALGIGAFAPKTLVAAGQAVKVDPAARPEAAGLIGCGVMAGYGAAVNTGQVRHGDTVAVIGCGGVGDAAVAGASLAGARRVIAVDVDDKKLDAATRFGATHTVNSRGTDPVAAVRELTAGHGVDVAIDAVGLPETYRQAFTMRDLAGVLVQVGVPQPEATVELSLADLFSHGGALKSSWYGDCLPSRDFPILIDQYLSGRLNLGAFVSETIGLGQVEEAFAKMGRGEVLRSVVTL
>NZ_CP045178.1|WP_077974175.1|1063967_1064864_+|IclR-family-transcriptional-regulator
MSSERREATKRSPEAEDARRKGGDNREEALADTASEGPVEGRSKSAKGAGSVQSVDRAVSVLEILARHGEAGVTDIADELGVHKSTAFRLVGVLENRGLVAQAKDRGKYYLGAGVLRLAGAAAVRLDISQEGAPVCRELADELGETVNIAVLDDDAAVNIMQARGSAAVTAQNWLGRRTPLHATSSGKVLLAHLPDTLREGLLARPLPRFTDRTVTGTVPLRAELKSVVEQGWAVAVEELEVGLAAVSAPVRAHDGNVIGALSASGPVYRLTPERLAELAIRTAAAGVDLSRRMGYGF
>NZ_CP045178.1|WP_077974397.1|1082011_1082815_-|helix-turn-helix-transcriptional-regulator
MRNVPLAETDGLDRAVLAIGTDYPPDHLLPFHRHRRAQFLYAATGVMQVETEDGAWSVPTHRAVLIPPTTSHQVTMVGVSTRSLYIEPGAVPWFPRDCRVVDVSALLRELVLDAVDMDPRYPEHGRDATVIQLILHEIRNLTPLPLDVPLPADEGLRRLCDAFLLAPDIHDPPARWAAALHVSERTLGRLFRAGTGLSFTQWRRRACVLHSLRHLAAGAPVTRVAATLGYENPAAFTAAFGSVVGRPPTAYGAVAVARADDDGDVRS
>NZ_CP045178.1|WP_077974398.1|1082907_1083714_+|sulfite-exporter-TauE/SafE-family-protein
MLTSLLVLFAFGCLTGVTTVLFGFGGGFITVPVVYGVLTLGADSGSDAMHVAVATSTAVMLVNSLMATVAQLRLGRVRRAYVWPLAAFVAVGAVIGSSAATWVSGPVLRILFAVYLLVTIVDSLLRKGFLSVADGTGPAPLGRFTSTFGGVGIGSVAAFLGVGGSVMTVPLLRRRGLPMTAATAMANPLSVPVAVAGTVVYALAAGAPAHSGRVGYVDLVSGIALLAGSLPTIAVVKRVTGRIPDRVHSIAYIALLVLVLLAMVLTGS
>NZ_CP045178.1|WP_077974400.1|1083981_1085400_-|hypothetical-protein
MFDPVIAPSGTLLGLLQRGRGDGTLHALTAPRAEALAALDQCVLRDPRHDWQVENRSLYYARLYLDLHGDLARISQHLFDAEDVLHTDESRTGLALAVLGHLASYGRGDALVLLRRYAATGANWAWALDELALRDDDRALRALAEPVLARFPRTPEGEAELTAAVRDAFEPRPWRLWAQDPRDEVGARVRAAGERGSFDRWQRQLTPAGPRPGWSVDAVLTWAHEGLERGAALHVPAARCLAAVAGPEDRPAIVAAARDGLDGARCTALRHLADAHDPLALDLIEAAAESPSGAVVDAALESFERMRSDAAVRRARRWAHRPDRLGSAAGRVLACRGGTQDAALVLGALREAVRGEGPDAPALWTLLDGTGRLGIACAAPVLRHVYRETTSSHLRGRAAAALAATDPSFPAGFAVECLWDCEESTRELAARCAETADARVVEQLRRLASDPAEEDDVQTAVRGRIGPDATAA
>NZ_CP045178.1|WP_077974402.1|1085705_1086098_-|ankyrin-repeat-domain-containing-protein
MAETPDPEVVELATKIFDLARRGDTQTLVSYVDAGVPAGLTNDRGDCLVMLAAYHGHADAVRALLERGADADQANDRGQTPLAGAVFKGEDDVIKALLDGGADPSAGAPSALDTARMFGKTDLVELFSAE
>NZ_CP045178.1|WP_077974404.1|1086469_1086664_+|hypothetical-protein
MILSISGVVLLGIIVFLFFRKDGLKASHGLVCALFGFYLAGTAIAPSIKAGGASLASLLGGIKF
>NZ_CP045178.1|WP_077974406.1|1086770_1088456_+|hypothetical-protein
MARRPLPRILSNGTASLTRSRELARTAADNATDVLHPLITIARGLRRLAATGRRKWDQTPKERRGPLLFMVAAVVLVVALAPYGPLLALITLLAAAAWTGRDRTPRIPEGPDEAQRLRLQSLYEALVPYFSVPEDPNPLFAHGGEWESALGSYEFDGSGRVTSLVISYPAYFPDGDAGSRARIEQLVHAKSGRGREYHFSWHEEAGELTVTVLPPLPTDIAAQPFVTTPGETVLGFSDPTGVQRTLPVRDGENEEPRDVPPVVWRTGVRSTEPHLFAVGAPGSGTTTLLRSIALQALRHGDVLIVEGGGIGDYACLTGRDGVLAVESGVSGALAALEWTAHETERRLIAANRARQAGHPQPDDTKRPLWILLDRPSVLTHLAEADERRDPQDLLEIPLRHGRSANVTVVVADQYDGFDALSESVLRHTRARVALGPATQDQVEAVLGVPPHTTPVTDMPPGRGYARLGAGQVHRLQVPATPDPYDDSAADSHRRAVLALLPPCSTRPGEEAQAGPAEEGPARQDPEGREEGEAGSEEGGAEGREGGRDTEPVAPRVSVTEV
>NZ_CP045178.1|WP_077974407.1|1088504_1090019_-|PLP-dependent-aminotransferase-family-protein
MATQWTSAMGSAQLARLIASQRAEAAHSGARKQPAYRALADGIRLLVLEGRVPVAARLPAERELALALSVSRTTVAASYEALRTEGFLESRRGAGSWTAVPAGNPLPARGLEPLPPESLGSMIDLGTASLPAPEPWLTRAVQGALEALPPHAHTHGDYPAGLPALRRTLADRYTARGIPTMPEQIMVTTGAMGAMDAICHLFAGRGERIAVESPSYANILQLMREAGARLVPVAMTDGLKGWDLDRWRQVLREASPRLAYVVADFHNPTGALADEDRRRQLVEAARSAGAVLVVDETMAELRLDAAQGDEPLMPPPVCAFDPAGSTVVTVGSASKAFWAGLRIGWVRAAPEVIRSLVSARAYADMGTPVLEQLALNWLLTTGGWQHAVELRRTQARENRDALVAAVRRELPEWEFEVPAGGLTLWVRTGGLSGSRIAEVGERVGVRVPSGPRFGVDGAFEGFVRLPFTVGGALADEAAQRLAAAARLVRGGEGMGTEGPRTLIA
>NZ_CP045178.1|WP_077974432.1|1090293_1090902_+|hypothetical-protein
MVQLFVGLALYGFSSGLLIRSGLGLEPWNVLNQGIAEHTGLSIGTVAIVVGAAVLLLWIPIKQRPGLGTVSNVLVVGLSMDATLALVPDGHGWPARVALLVAGIVLNGLATGLYIAARFGAGPRDGLMTGLHRLTGRSLRLCRTAIEIVVVVSGFALGGTVGVGTVLYAVAIGPLAQFFLRICTVPQGPRAGVRAARGILRR
>NZ_CP045178.1|WP_077974409.1|1090898_1091666_+|glycerophosphodiester-phosphodiesterase
MTTRVRHPFLDHPAPLAFAHRGGAAGGLENTVRAFRRAAATGYRYMETDVHTTADGRLVAFHDETLDRVTDGGGRIAELPWSEVSRARVGGVEPVPLFEELLETFPGARWNVDLKTESALAPLLELIRRTDAWDRVCVGSFSESRVVRALRLAGPRLATSLGTRGALGLRLRGYGLPGAVRRSALSAQVPERHGRIRVVDEAFVRAAHARGLQVHVWTVNDAERMADLLDLGVDGIMTDHIETLREVLAARGRWE
>NZ_CP045178.1|WP_077974410.1|1091732_1093091_+|MFS-transporter
MGADTVLADEAGDRAKERRREQRGWYFYDWACSVYSTSVLTVFLGPYLTGVAEAAADRDGFVHPLGIPVRAGSFFAYSVSLSVIAAVIVMPLAGAAADRGGRKKPLLAAAAYTGAAATAAMFFLDGDRYLLGGALLVIANASIAVSMVVYNAYLPQIAEPEERDAVSSRGWAFGYAAGALVLIVNLVLFMGHETFGVSESTAVRICLASAGVWWAVFTLVPLRRLRERPSTRTASERAPGGGWRQLVATVKDMRRRPLTLGFLLAYLMYNDGVQTVISQASVFGSQELGLDQSTLIVAVLLVQVLAVAGALAMGRLARRYGAKRTILGSLVAWTLTVGAGYLLPADAPVWFFVLAVAIGLVLGGSQALSRSLFSHLVPAGKEAEYFSAYEMSDRGMSWLGPLLFGLTYQLTGSYRYAILSLVVFFVVGFILLARVPVSRAIRDAGNPVPEKI

Crispr_ID: NZ_CP045178_3

• CRISPR_ID: NZ_CP045178_3
• CRISPR_location: 1657958-1658027
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_3

Consensus_repeat	Method
GCGGGGGGTACGGCGGCTCCGGCGG	CRISPRCasFinder

spacers of NZ_CP045178_3

>3.1|1657983|20|NZ_CP045178|CRISPRCasFinder
CTCCGGCGGGAGCGGGGGGT

CRISPR arrays and Neighbor proteins around NZ_CP045178_3

CRISPR arrays

The CRISPR arrays of NZ_CP045178_3

>merge|NZ_CP045178|3|1657958-1658027|CRISPRCasFinder
GCGGCGAAGGCGGGGGGTACGGCGGCTCCGGCGGGAGCGGGGGGTACGGCGGCTCCGGCGGGAGCGGGGG

>NZ_CP045178|3|2|1657958-1658027|CRISPRCasFinder
GCGGCGAAGGCGGGGGGTACGGCGG	CTCCGGCGGGAGCGGGGGGT
ACGGCGGCTCCGGCGGGAGCGGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077972038.1|1653607_1656253_-|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|213180
NZ_CP045178.1|WP_077972044.1|1648945_1649185_-|chaplin	unknown	unknown	gnl|CDD|367652
NZ_CP045178.1|WP_077972105.1|1649834_1650476_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP045178.1|WP_077972097.1|1661383_1662754_-|MFS-transporter	unknown	unknown	gnl|CDD|340897
NZ_CP045178.1|WP_077972049.1|1645283_1646240_-|SPFH/Band-7/PHB-domain-protein	unknown	unknown	gnl|CDD|223407
NZ_CP045178.1|WP_077972046.1|1647763_1648552_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077972039.1|1652493_1653366_+|transglycosylase-SLT-domain-containing-protein	unknown	unknown	gnl|CDD|381605
NZ_CP045178.1|WP_077972020.1|1667015_1667246_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP045178.1|WP_077972024.1|1664553_1665258_-|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl|CDD|273824
NZ_CP045178.1|WP_077972040.1|1650501_1651647_-|GAF-domain-containing-sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP045178.1|WP_077972033.1|1660000_1660546_-|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|224973
NZ_CP045178.1|WP_077972026.1|1663774_1664548_-|enoyl-ACP-reductase-FabI	unknown	unknown	gnl|CDD|236124
NZ_CP045178.1|WP_077972042.1|1649421_1649667_-|chaplin	unknown	unknown	gnl|CDD|367652
NZ_CP045178.1|WP_077972030.1|1660616_1660829_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077972048.1|1646351_1646783_-|NfeD-family-protein	unknown	unknown	gnl|CDD|224501
NZ_CP045178.1|WP_077972099.1|1658640_1659858_+|phosphoserine-phosphatase-SerB	unknown	unknown	gnl|CDD|319803
NZ_CP045178.1|WP_077972022.1|1665502_1667026_+|TldD/PmbA-family-protein	unknown	unknown	gnl|CDD|223389
NZ_CP045178.1|WP_077972106.1|1646849_1647641_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224044
NZ_CP045178.1|WP_077972028.1|1662914_1663619_+|FadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225097
NZ_CP045178.1|WP_077972018.1|1667587_1669000_+|peptidase	unknown	unknown	gnl|CDD|223389

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077972038.1|1653607_1656253_-|FHA-domain-containing-protein	gnl|CDD|213180	cd03213, ABCG_EPDR, Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily. ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus.	3.49103e-74
NZ_CP045178.1|WP_077972044.1|1648945_1649185_-|chaplin	gnl|CDD|367652	pfam03777, DUF320, Small secreted domain (DUF320). Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	5.86107e-16
NZ_CP045178.1|WP_077972105.1|1649834_1650476_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.89954e-81
NZ_CP045178.1|WP_077972097.1|1661383_1662754_-|MFS-transporter	gnl|CDD|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.53688e-127
NZ_CP045178.1|WP_077972049.1|1645283_1646240_-|SPFH/Band-7/PHB-domain-protein	gnl|CDD|223407	COG0330, HflC, Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones].	1.50134e-66
NZ_CP045178.1|WP_077972039.1|1652493_1653366_+|transglycosylase-SLT-domain-containing-protein	gnl|CDD|381605	cd13402, LT_TF-like, lytic transglycosylase-like domain of tail fiber-like proteins and similar domains. These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	4.27472e-29
NZ_CP045178.1|WP_077972020.1|1667015_1667246_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.634e-07
NZ_CP045178.1|WP_077972024.1|1664553_1665258_-|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl|CDD|273824	TIGR01830, 3-oxoacyl-_reductase_FabG, 3-oxoacyl-(acyl-carrier-protein) reductase. This model represents 3-oxoacyl-[ACP] reductase, also called 3-ketoacyl-acyl carrier protein reductase, an enzyme of fatty acid biosynthesis. [Fatty acid and phospholipid metabolism, Biosynthesis].	5.79443e-121
NZ_CP045178.1|WP_077972040.1|1650501_1651647_-|GAF-domain-containing-sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.28145e-54
NZ_CP045178.1|WP_077972033.1|1660000_1660546_-|histidine-phosphatase-family-protein	gnl|CDD|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	2.62799e-45
NZ_CP045178.1|WP_077972026.1|1663774_1664548_-|enoyl-ACP-reductase-FabI	gnl|CDD|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	2.58862e-164
NZ_CP045178.1|WP_077972042.1|1649421_1649667_-|chaplin	gnl|CDD|367652	pfam03777, DUF320, Small secreted domain (DUF320). Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	5.39821e-16
NZ_CP045178.1|WP_077972022.1|1665502_1667026_+|TldD/PmbA-family-protein	gnl|CDD|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	2.29974e-96
NZ_CP045178.1|WP_077972048.1|1646351_1646783_-|NfeD-family-protein	gnl|CDD|224501	COG1585, COG1585, Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion].	4.65501e-15
NZ_CP045178.1|WP_077972099.1|1658640_1659858_+|phosphoserine-phosphatase-SerB	gnl|CDD|319803	cd07500, HAD_PSP, phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p. This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	3.92911e-91
NZ_CP045178.1|WP_077972106.1|1646849_1647641_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	9.83102e-94
NZ_CP045178.1|WP_077972028.1|1662914_1663619_+|FadR-family-transcriptional-regulator	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	1.40986e-46
NZ_CP045178.1|WP_077972018.1|1667587_1669000_+|peptidase	gnl|CDD|223389	COG0312, TldD, Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only].	1.6882e-38

Protein sequences

>NZ_CP045178.1|WP_077972038.1|1653607_1656253_-|FHA-domain-containing-protein
MFDIPRLPNDGAHSGDNSAVGHGVPELVLELNGRTWTLDPSRPYTLGRDPQGDIPLDDARVSWRHATVSWGGRSWLIEDHGSTNGTFVQGRRIHQMEIGPGSTVNLGNANDGPRLVLTSPAAAVAGRQQVREQPPRQTPPPEEPARGGPGWVQPPPQQQQPPQQNWQPQQQHVGQQPPTPRQPVAQPPLPRQGGGSPQDPGDGAWAPPVYGDRSPTTFHQVALGRRMRIGRALENELVVSDLQVSRLHAEFTASPDGRFEIRDLGSHNGTYVNGQPLPKSGTALLGPNDIVGVGHSTFRLVDGRLEEFVDSGDISFSARHLTVTVDGGKQILKDVSFGVPEKSLIAVIGPSGSGKSTLLKALTGYRPADEGDVLYDSRNLYKQFAELRQRIGLVPQDDILHKELTVRTALKYAAKLRFPADTTGQEREARISEVLRELKLDVHAEKKVTSLSGGQRKRVSVALELLTKPSLIFLDEPTSGLDPGMDRDVMQLLRGLADDGRTVLVVTHSVAELAICDKLLVMAPGGSVAYFGPPEEALNFFGYQSWADVFSAFEEYRDYDWAGRWKGSQHYQMYAADIDAVAPQSVEVPHTRATRPPKPQGWFPQLWTLMRRYVSVIVSDHGFMGLMVALPAVLGLVSVVIPADFGLGPPTVKGEFNTDAGTIMLILAVGMCFSGAANSVRELIKERVIYERERATGLSRSAYLVSKIIVLGLITAVQGVIICAIGFLPRKLPEKGLIISGLPAVEMCVVISALGLTSMMFGLVISSLVRTQEKTMQLLVMFAIVQVVFTGTLFKVFDSPGVEQFAWLMPSRWAIAGVGTTLDLSRISPVDQKNPGNLDPLWAHEASQWAINLSVLLFIGLVCGIAVVRLLRRHEPEVMRK
>NZ_CP045178.1|WP_077972039.1|1652493_1653366_+|transglycosylase-SLT-domain-containing-protein
MTDINTVFRSIQDRISTVPGHLSTFQGRVSSTAKERFSSVQGHVNTAQGRVGAAVPAALRGGNLNRNQKLSIAGIATCSAAVLATGIAVPAASSGSSSATQASSASSASSVAWSSSTGDKQAKDLHASVTSQMANADQQAKDAQAKLKADTDAKSKASDAAAKANEQHTAKESANRSAPRTATYANNLDGWIKQSLDIMKERGIPGSYEGLHRNIMRESAGDTRAINNWDINAQNGIPSKGLLQTIQPTFEQYHVAGTSNDIYDPVANITAAANYAAHRYGSMDNVNSAY
>NZ_CP045178.1|WP_077972040.1|1650501_1651647_-|GAF-domain-containing-sensor-histidine-kinase
MTQGPQAGLYAVSSALLAMSRQLEMRDVLKTIVASARELLDAEYAALGVPDDHGGFAQFVVDGVSDEQWKAIGPLPRQHGILAAMLHEGRIERLADVREDPRFQRWPQAHPDMSDFLGMPVRYGDETIAALFLANKKDAKREGVCGFTAEDEELLMILAQHAAIALTNARLYERSRELTIAEERSRLAHELHDAVSQKLFSLRLTAQAASALVDRDPARAKGELKQVAALAAEAVDELRAAVVELRPAALDDDGLVATLRTQIRVLDRAHSARVTFSGGGIRALPAAQEEALLRVCQEALHNALRHSGAAHVDVALHRRGGGAVLRVGDDGSGFDPRAVRRAGRHLGLVSMRDRASGVGGALTVESGPGRGTTIEMEVPGG
>NZ_CP045178.1|WP_077972105.1|1649834_1650476_-|response-regulator-transcription-factor
MGAKRIRVLLVDDHQVVRRGLRTFLEVQDDIEVVGEASDGAEGVAGAQELKPDVVLMDIKMPGMDGVEALRTLRELENPARVLIVTSFTEQRTVIPALRAGATGYVYKDVDPDALAGAIRSVHAGHVLLQPEVAGVLLSQEGGTGQGRGGQLTERETEVLGLIADGRSNREIARALVLSEKTVKTHVSNILMKLDLSDRTQAALWAVRHGAGG
>NZ_CP045178.1|WP_077972042.1|1649421_1649667_-|chaplin
MKNLKKAAAVTMMAGGLVAAGAGMASATDGAHATGAATHSPGVGSGNLAQVPVNVPVNAVGNTVNVIGVLNPAFGNLGLNH
>NZ_CP045178.1|WP_077972044.1|1648945_1649185_-|chaplin
MKIAKKAALTVLAAGFAVAAPAGAAFADAGAHGAATASPGVASGNLVQVPVNVPVNVTGNSVNVIGVLNPAFGNASVNH
>NZ_CP045178.1|WP_077972046.1|1647763_1648552_+|hypothetical-protein
MLSEPRSGRLAAWGNALLAGLVSPDDAALAIVGEDAVHRVEGLPGESGPVGLTLALGRLRALGVTGLRTALPAPGHPLGLSGPPEFNARALEAEEAVVAVGAALGLVPEVTEKGPAGDVHVEVVWRCQPVRDAPPADVPSLGEAERELAEALREATQVLSRLDVAGSGPRAEAAVEAYRARAERGREVLAPGYPPRAVRVLELAQRVGLLVSVAYENGPGGAVTAAEIAARSLALRPVERTARRAQVAAYNAYVERLERGRE
>NZ_CP045178.1|WP_077972106.1|1646849_1647641_-|ABC-transporter-ATP-binding-protein
MSDVLELVDVSVVREGRALVDQVSWSVKEGERWVILGPNGAGKTTLLNVASSYLFPSKGTARILGEELGKVDVFELRPRIGVAGIAMAEKLPKRQTVLETVLTAAYGMTATWREDYEEVDERRARAFLDRLGMTEYLDRRFGTLSEGERKRTLIARALMTDPELLLLDEPAAGLDLGGREDLVRRLGRLARDPIAPSMIMVTHHVEEIAPGFTHVLMIRQGEVLAAGPLELELTSRNLSRCFGLPLVVEQRGERWTAQGLPMG
>NZ_CP045178.1|WP_077972048.1|1646351_1646783_-|NfeD-family-protein
MDIEVWVWWLIGAVALGIPLVVTAMPEFGMLALGAAAASVTAGVGAGIITQVLVFAAVSVALIGVVRPIAARHRAQRPQLASGIDALKGRQAVVVEQVDAGDGGRVKLGGEIWSARPLDKSQSFAVGQEVDVVDIDGATAVVM
>NZ_CP045178.1|WP_077972049.1|1645283_1646240_-|SPFH/Band-7/PHB-domain-protein
MEPIIIVLIILVVLVFIALIKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDSIRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDARAATYEVASYIQAIEQLTVTTLRNIIGGMDLERTLTSREEINAALRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILTAEGIRQSQILTAEGEKQSAILRAEGEAKAAALRAEGEAQAIRTVFESIHAGDPDQKLLSYQYLQMLPKIAEGDANKLWIVPSEIGDALKGLSGAFGNFGGMGGGPTAPSVPSPAKPPAERREQPRID
>NZ_CP045178.1|WP_077972099.1|1658640_1659858_+|phosphoserine-phosphatase-SerB
MRASLPPETADVPTLLVKIFGKDRPGITAGLFDTLAAFSVDVIDIEQVVTRGRIVLCALVTRPHSDHEGELRSTVHSWAESLKLQAEILSGTGDNQPRGEGRSHVTVLGVPLTAESTAAIAARITSTGGNIDRIFRLAKYPVTAVEFAVSGVATEPLRTALATEGAALGVDVAVVASGIQRRAQRLVVMDVDSTLIQDEVIELFAAYAGCADEVAEVTAAAMRGELDFAQSLHARVALLAGLDVSVVEKVRGEVRLTPGARTLIRTLKRLGYQVGVVSGGFTQVTDDLKERLGLDFAQANTLEIVDGKFTGRVVGEVVDRAGKARLLRRFAKEAGVPLAQTVAIGDGANDLDMLNAAGLGVAFNAKPLVREAAHAAVNVPFLDTVLYLLGITREEVEAADAHDES
>NZ_CP045178.1|WP_077972033.1|1660000_1660546_-|histidine-phosphatase-family-protein
MSAAVSSGETSPETRTIVLLRHAKADWPEVSDHERPLAERGRQDAAAVGRRLAGTGIDFDLAICSTAVRTRETWKLAVPELPERPRTVYEERVYEASPGELIAVLNETPDEVTGALLIGHNPGVQGLAEILAGKADSDARTALGNRGFPTAAFAVLTFTGPWKSLEPGTATLTDYWAPHEA
>NZ_CP045178.1|WP_077972030.1|1660616_1660829_-|hypothetical-protein
MTARSHTRHPADTGTAETRLSWWSIALPSLAFAVLLLMILHPADAQAATTVPSVGHFLERVQHAWVNRAP
>NZ_CP045178.1|WP_077972097.1|1661383_1662754_-|MFS-transporter
MVQHDETQTETAGPQASADADAAVTSAAVTSARDGKTTAPGGGSPAAATARTWLPRLMAAGIVLAALNLRPGITSLGSLLEEVRDGLGMNGTLAGLLTSVPPLCFAIFGYMAPRLSRRFGPGAVVCAGMAAITAGLVIRPFTGTTVGFLAATALALAGIAMSNVLMPVIVKRWFPDRVGSMTGLYSMALAIGTSLAAAITVPMTDALGGSWQGGLAIWAVLGAAAVLPWIPLVKHHGTVDDGAPARRPGARNPATTSGPAVTRSRTAWALAVFFGLQATAAYITMGWMPQIFRDAGVPAGTAGVLLAVIMAMGIPLAFVIPRVATRMTHQGPIVAVLGACGLGGYAGLYLAPAGGAWAWAVLLGISNCAFPLALTMVGLRARTGAGVAKLSAFAQSTGYLISIPGPLLVGVLNQHSGGWGLPIAFMACLMVPQIVMGVLAGRNRTIEDEHAAATAA
>NZ_CP045178.1|WP_077972028.1|1662914_1663619_+|FadR-family-transcriptional-regulator
MPLSSPRRSALSEQVIAELRAQVSSGEWPVGTRIPTESALVEQLGVARNTVREAVRALAHNGLLDIRQGSGTYVVATSELAGVMHRRFAGTDPKDIAEMRATLESSAARLAATRRTEKDLRQFDTLLGRRQKAWESGDAEAFVLADATFHMAVVAASHNTVMTEIYADLSEVMRDWLRADVGEILTDEVNLDHAPIVEAIRARDVERAGAEAACRNGLLGGRRPTVKSAVAEPH
>NZ_CP045178.1|WP_077972026.1|1663774_1664548_-|enoyl-ACP-reductase-FabI
MSGILAGKRIIVTGVITQASIAFHVARLAQEEGADVVLTGFGRLSLVERIAKRLPKPVPVIELDVQDQGHLDGLAAKIAEHYGDDAGVDGVVHSIAFGPQGVFNFLEAPWEDVSTALHVSAYSLKSLTMSLLPLLEKRGGSVVGLTFDASLAWPKYDWMGVAKAALESTSRYLARDLGAKNIRCNLVSAGPLGSMAAKSIPGFEELATVWDSRAPLNWELSDPEPAARGVVALLSDWFPKTTGEIVHVDGGIHAMGA
>NZ_CP045178.1|WP_077972024.1|1664553_1665258_-|3-oxoacyl-[acyl-carrier-protein]-reductase
MSRSVLVTGGNRGIGLAIARAFADAGDKVAVTYRSGEPPAGFLGVKCDITDSEQVDLAFKEIEEQHGPVEVLVANAGVTKDQLLMRMSEDDFTSVIDTNLTGTYRVVKRANRAMLRAKKGRVVLISSVVGLLGSAGQANYAASKAGLVGFARSLARELGSRNITFNVVSPGFVDTDMTQVLTDEQRAGIVAQVPLGRYAKPEEIAATVRFLASDDASYITGAVIPVDGGLGMGH
>NZ_CP045178.1|WP_077972022.1|1665502_1667026_+|TldD/PmbA-family-protein
MAHEVDQSFLALPLRALADAALARARALGAEHADFRLERVRDASLRLRDARPSGASDSTDLGYAVRVVHGGAWGFASGVDLTMDAAARVAGQAVAMAKLSAKVSEAAGSDERVSLADEPVHADREWVSAYDLDPFDVPEEEKTALLAEWSARLLRADGVAHADASLHFVHENKFYADTAGTVTTQQRVRLHPQLTAVAVDATTGEFDSMRTLAPPVGRGWEYLTGTGWDWDGELERIPGLLAEKMRAPSVRAGTYDMVVDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDRLGTLKYGSEIMNVTGDRTAEHGLSTIGYDDEGVAGQSWDLIKDGRLVGYQLDRRIARLTGFERSNGCAYADSPSHVPVQRMANVSLRPDPGGLATEDLIGGVDRGIYVVGDRSWSIDMQRYNFQFTQQRAYAIRNGRLAGQLRDVAYQGITPEFWGSMEKVGGPSTYVLGGAFNCGKAQPGQVAAVSHGCPSALFRGVNILNTAREGGR
>NZ_CP045178.1|WP_077972020.1|1667015_1667246_+|DUF397-domain-containing-protein
MGGEGAGWAGRRRGAALTGRSPEEPHARLYARPRVEVGQGVSRVVPVRDSKVANGPIVTVTSATWTSFVTAVRVGI
>NZ_CP045178.1|WP_077972018.1|1667587_1669000_+|peptidase
MSRSSRNSSKPYEIVERALELSVADGCVVIAEEESSANLRWARNSLTTNGVTRGRTLTVVATVGGAEGTASGVVSRSGVTGAELESLVRAAEEAARGAGPAEDGGPLVAPAQSLPVSADFTDAPGETTSAVFDAFAPALGDSFARASAGGRELYGFASHELTSTYLGTSTGLRLRHDQPSGTLELNAKSPDGSRSAWAGRATRDFKDVDPAALDAELATRLGWAERRVELPAGRYETLLPPTAVADLLIYQLWSSGARDAVEGRTVFSSPGGATRLGERLATLPLTLRSDPSEPGLESAPFVVAHSSGGDSSVFDNGLPVGPTDWISGGELSRLVTTRHTAALTGLPVAPSGGNLVLDGGGDRSLEEMVAGTERGLLLTCLWYIREVDPATLLLTGLTRDGVHLVENGEVTGVVNNFRFNESPVDLLGRATEAGRTERTLPREWGDYFTRAAMPALRVPDFHMSSVSQGV

Crispr_ID: NZ_CP045178_4

• CRISPR_ID: NZ_CP045178_4
• CRISPR_location: 2006256-2006879
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 11 spacers

Consensus repeat of NZ_CP045178_4

Consensus_repeat	Method
GNCCGGCNCGGNGACCTNNCC	CRT

spacers of NZ_CP045178_4

>4.1|2006277|49|NZ_CP045178|CRT
CGACACAGTGGCCTGACCGGCGCGGGGCCCTTGGCCGACACAGTGGCCT
>4.2|2006347|25|NZ_CP045178|CRT
CCGCACGGGGACCAGACGGTGACCC
>4.3|2006393|31|NZ_CP045178|CRT
CCGGACGGTGACCAGACCGGCGCGGGCCCCT
>4.4|2006445|30|NZ_CP045178|CRT
GGCACGGGCCCTTGGCCGACACAGTGGCCT
>4.5|2006496|25|NZ_CP045178|CRT
CCGCACGGGGACCAGACGGTGACCC
>4.6|2006542|31|NZ_CP045178|CRT
CCGGACGGTGACCAGACCGGCGCGGGCCCCT
>4.7|2006594|30|NZ_CP045178|CRT
GGCATGGGGACCAGACCGGCACGGGCCCTT
>4.8|2006645|25|NZ_CP045178|CRT
GGCGCGAGGACCTTGCCCCGCACGG
>4.9|2006691|48|NZ_CP045178|CRT
GGCGCGGGGACCTTGCCCCGCACGGGGACCAGACCGACGCGGGCCCTT
>4.10|2006760|47|NZ_CP045178|CRT
GGCGCGAGGACCTTGCCCCGCACGGGACCAAACCGGCGCGGGCCCCT
>4.11|2006828|31|NZ_CP045178|CRT
GGCACGGTGACCAGACCGGCGCGCGGCCCTT

CRISPR arrays and Neighbor proteins around NZ_CP045178_4

CRISPR arrays

The CRISPR arrays of NZ_CP045178_4

>merge|NZ_CP045178|4|2006256-2006879|CRT
GACCGGCGCGGGGCCCTTGGCCGACACAGTGGCCTGACCGGCGCGGGGCCCTTGGCCGACACAGTGGCCTGACCGGCGCGGGGACCTTGCCCCGCACGGGGACCAGACGGTGACCCGACCGGCGCGGGGACCTTGCCCCGGACGGTGACCAGACCGGCGCGGGCCCCTGACCGGCACGGGGACCTGACCGGCACGGGCCCTTGGCCGACACAGTGGCCTGACCGGCGCGGGGACCTTGCCCCGCACGGGGACCAGACGGTGACCCGACCGGCGCGGGGACCTTGCCCCGGACGGTGACCAGACCGGCGCGGGCCCCTGACCGGCACGGTGACCAGACCGGCATGGGGACCAGACCGGCACGGGCCCTTGGCCGACACAGTGACCTGACCGGCGCGAGGACCTTGCCCCGCACGGGGACCAGACGGTGACCAGACCGGCGCGGGGACCTTGCCCCGCACGGGGACCAGACCGACGCGGGCCCTTGGCCGACACAGTGACCTGACCGGCGCGAGGACCTTGCCCCGCACGGGACCAAACCGGCGCGGGCCCCTGACCGGCACGGTGACCTGACCGGCACGGTGACCAGACCGGCGCGCGGCCCTTGCCCCGCACGGGGACCGCATC

>NZ_CP045178|4|1|2006256-2006879|CRT
GACCGGCGCGGGGCCCTTGGC	CGACACAGTGGCCTGACCGGCGCGGGGCCCTTGGCCGACACAGTGGCCT
GACCGGCGCGGGGACCTTGCC	CCGCACGGGGACCAGACGGTGACCC
GACCGGCGCGGGGACCTTGCC	CCGGACGGTGACCAGACCGGCGCGGGCCCCT
GACCGGCACGGGGACCTGACC	GGCACGGGCCCTTGGCCGACACAGTGGCCT
GACCGGCGCGGGGACCTTGCC	CCGCACGGGGACCAGACGGTGACCC
GACCGGCGCGGGGACCTTGCC	CCGGACGGTGACCAGACCGGCGCGGGCCCCT
GACCGGCACGGTGACCAGACC	GGCATGGGGACCAGACCGGCACGGGCCCTT
GGCCGACACAGTGACCTGACC	GGCGCGAGGACCTTGCCCCGCACGG
GGACCAGACGGTGACCAGACC	GGCGCGGGGACCTTGCCCCGCACGGGGACCAGACCGACGCGGGCCCTT
GGCCGACACAGTGACCTGACC	GGCGCGAGGACCTTGCCCCGCACGGGACCAAACCGGCGCGGGCCCCT
GACCGGCACGGTGACCTGACC	GGCACGGTGACCAGACCGGCGCGCGGCCCTT
GCCCCGCACGGGGACCGCATC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077969216.1|2011813_2012644_-|metallophosphoesterase	unknown	unknown	gnl|CDD|277338
NZ_CP045178.1|WP_077969209.1|2002137_2003352_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP045178.1|WP_077969221.1|2018734_2019763_-|C40-family-peptidase	unknown	unknown	gnl|CDD|366353
NZ_CP045178.1|WP_107502882.1|2003687_2004518_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251
NZ_CP045178.1|WP_077969207.1|1998794_1999799_-|2-hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240659
NZ_CP045178.1|WP_107502881.1|1996589_1996646_+|trp-operon-leader-peptide	unknown	unknown	unknown
NZ_CP045178.1|WP_077969212.1|2007795_2008737_-|ROK-family-glucokinase	unknown	unknown	gnl|CDD|273246
NZ_CP045178.1|WP_077969219.1|2016156_2017422_+|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|378217
NZ_CP045178.1|WP_077969208.1|2000040_2001069_-|6-phosphofructokinase	unknown	unknown	gnl|CDD|274155
NZ_CP045178.1|WP_077969285.1|2001282_2001984_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP045178.1|WP_077969218.1|2014835_2015978_-|glycosyltransferase-family-4-protein	unknown	unknown	gnl|CDD|340831
NZ_CP045178.1|WP_107502876.1|2006940_2007699_-|endonuclease	unknown	unknown	gnl|CDD|197318
NZ_CP045178.1|WP_077969210.1|2005511_2006189_+|hypothetical-protein	unknown	unknown	gnl|CDD|376441
NZ_CP045178.1|WP_077969214.1|2009901_2011137_-|ArsA-family-ATPase	unknown	unknown	gnl|CDD|223082
NZ_CP045178.1|WP_077969206.1|1996757_1998680_+|phenazine-specific-anthranilate-synthase	unknown	unknown	gnl|CDD|223225
NZ_CP045178.1|WP_077969213.1|2008999_2009530_-|hypothetical-protein	unknown	unknown	gnl|CDD|375065
NZ_CP045178.1|WP_107502880.1|1995091_1996441_-|3-deoxy-7-phosphoheptulonate-synthase-class-II	unknown	unknown	gnl|CDD|366662
NZ_CP045178.1|WP_077969217.1|2012963_2014760_+|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|341233
NZ_CP045178.1|WP_107502877.1|2017458_2018649_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969287.1|2004739_2005519_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|224561

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077969216.1|2011813_2012644_-|metallophosphoesterase	gnl|CDD|277338	cd07392, MPP_PAE1087, Pyrobaculum aerophilum PAE1087 and related proteins, metallophosphatase domain. PAE1087 is an uncharacterized Pyrobaculum aerophilum protein with a metallophosphatase domain. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	5.0086e-17
NZ_CP045178.1|WP_077969209.1|2002137_2003352_-|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.3588e-19
NZ_CP045178.1|WP_077969221.1|2018734_2019763_-|C40-family-peptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	3.68332e-29
NZ_CP045178.1|WP_107502882.1|2003687_2004518_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	8.17203e-48
NZ_CP045178.1|WP_077969207.1|1998794_1999799_-|2-hydroxyacid-dehydrogenase	gnl|CDD|240659	cd12183, LDH_like_2, D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains. D-Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, and is a member of the 2-hydroxyacid dehydrogenase family. LDH is homologous to D-2-hydroxyisocaproic acid dehydrogenase (D-HicDH) and shares the 2-domain structure of formate dehydrogenase. D-2-hydroxyisocaproate dehydrogenase-like (HicDH) proteins are NAD-dependent members of the hydroxycarboxylate dehydrogenase family, and share the Rossmann fold typical of many NAD binding proteins. HicDH from Lactobacillus casei forms a monomer and catalyzes the reaction R-CO-COO(-) + NADH + H+ to R-COH-COO(-) + NAD+. D-HicDH, like the structurally distinct L-HicDH, exhibits low side-chain R specificity, accepting a wide range of 2-oxocarboxylic acid side chains. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	6.56271e-170
NZ_CP045178.1|WP_077969206.1|1996757_1998680_+|phenazine-specific-anthranilate-synthase	gnl|CDD|223225	COG0147, TrpE, Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism].	2.93233e-52
NZ_CP045178.1|WP_077969212.1|2007795_2008737_-|ROK-family-glucokinase	gnl|CDD|273246	TIGR00744, Glucokinase_Glucose_kinase., ROK family protein (putative glucokinase). This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General].	1.06076e-140
NZ_CP045178.1|WP_077969219.1|2016156_2017422_+|DUF2029-domain-containing-protein	gnl|CDD|378217	pfam09594, GT87, Glycosyltransferase family 87. The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM. The family also includes alpha(1-->3) arabinofuranosyltransferase, invloved in the synthesis of of mycobacterial arabinogalactan.	7.77352e-06
NZ_CP045178.1|WP_077969208.1|2000040_2001069_-|6-phosphofructokinase	gnl|CDD|274155	TIGR02483, ATP-dependent_6-phosphofructokinase_1, phosphofructokinase. Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis].	0
NZ_CP045178.1|WP_077969285.1|2001282_2001984_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.31352e-63
NZ_CP045178.1|WP_077969218.1|2014835_2015978_-|glycosyltransferase-family-4-protein	gnl|CDD|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.71713e-67
NZ_CP045178.1|WP_107502876.1|2006940_2007699_-|endonuclease	gnl|CDD|197318	cd09084, EEP-2, Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2. This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps, proteins.	2.87052e-17
NZ_CP045178.1|WP_077969210.1|2005511_2006189_+|hypothetical-protein	gnl|CDD|376441	pfam01040, UbiA, UbiA prenyltransferase family.	0.00202368
NZ_CP045178.1|WP_077969214.1|2009901_2011137_-|ArsA-family-ATPase	gnl|CDD|223082	COG0003, ArsA, Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning].	8.76338e-37
NZ_CP045178.1|WP_077969213.1|2008999_2009530_-|hypothetical-protein	gnl|CDD|375065	pfam17230, DUF5304, Family of unknown function (DUF5304). This family of unknown function is found in Actinobacteria.	4.27133e-56
NZ_CP045178.1|WP_107502880.1|1995091_1996441_-|3-deoxy-7-phosphoheptulonate-synthase-class-II	gnl|CDD|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
NZ_CP045178.1|WP_077969217.1|2012963_2014760_+|long-chain-fatty-acid--CoA-ligase	gnl|CDD|341233	cd05907, VL_LC_FACS_like, Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases. This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.	0
NZ_CP045178.1|WP_077969287.1|2004739_2005519_+|alpha/beta-fold-hydrolase	gnl|CDD|224561	COG1647, COG1647, Esterase/lipase [General function prediction only].	5.81254e-37

Protein sequences

>NZ_CP045178.1|WP_077969210.1|2005511_2006189_+|hypothetical-protein
MAEHGADSDESREPEESGVPFDEDAAWAAIVAGYGDEPPDPPGAKPFKSVEGLAGLDAGVNGPATAGTGDAKNSAADADKIQGDKVVRGDRSRDDTDGDSPAQGGGDASADRPLGGSIAFAPGVGPRDHSLTEPSDGGQEDDDEGHFVPPEPPPLPSPDVTAKFAWLAVIGGPVLALVAVLLGWPMTWWLATLTIGGFVGGFCTLVARMKGDDEIDDDPGRGAVV
>NZ_CP045178.1|WP_077969287.1|2004739_2005519_+|alpha/beta-fold-hydrolase
MPVLPGAEPYRHEGGEVGVLLCHGFTGTPQSLLPWARFLAERGLTVSLPLLPGHGTRWEDMQITGWPDWYAEVDREFRALRERCAQVFVMGLSMGGALALRLAEVHGDEVAGVVVVNPGMKVHGLAARALPVVKHFVPSTKGLVSDIAKEGSEESGYHRVPLRAAHSLSRLFRLVDGRLPQVTQPLLLLRSRRDHVVPPVDSARVLSRVSSTDVTEVVLEQSYHVATLDHDASRIFEESHAFIGRLTPSVGKEGTASGG
>NZ_CP045178.1|WP_107502882.1|2003687_2004518_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MKLSLGGSLKLAFRPWVEGMENIPFEGPAILASNHLSFSDSFFLPAVLDRKVTFIAKDEYFTTPGIKGRLTAAFFKGVGQLPVDRSGSRGAGEAAIKSGVEVLERGELFGIYPEGTRSPDGRLYRGKPGGLARVALASGAPVIPVAMIDTEKIQPPGQVVPKLMRPGIRIGKPLEFARYQGMEHDRFVLRAVTDEVMYEIMRLSGQEYVDIYATAAKRQLADAAKKRAEAAKRAGASGAAPASPGSGAAPAPPDAGSGADPSGAERAKKGGGEAAA
>NZ_CP045178.1|WP_077969209.1|2002137_2003352_-|sensor-histidine-kinase
MVKRERVMRMSVEQPLWRALTAYRVLTMLYAVGLFISARGDFVRPWVAVAYFAVLAPWTLITLPRVAGATACTRGFLAADLTIALTGILLTPAADAHARIAAGGPTLPSIWTAGAVLAFALKGGWRWAAAASALVGVANIVQRGAVTQDTLHNVLLVWVASIAIGYVVEVARASERTLARALEIEAVTRDRERLARDIHDGVLQVLAMVQRRGTALGGEAAELGRLAGEQEAALRTLVTGGLNAASHVSEDAAEGAVVRAMDIPDEEETGEERDLRPLLAPHASSRVSFAEPGAPVLLPQRSARELAAAVAAALDNVRVHAGEAARAWILVEDEPGTVTVTVRDDGPGIPEGRLAQAEGEGRLGVAQSIRGRLRDIGGTAELISVPGQGTEVELTVTRDASRGA
>NZ_CP045178.1|WP_077969285.1|2001282_2001984_-|response-regulator-transcription-factor
MGEGGKVNDTTAEDAPIRVMVVDDHPMWRDAVARDLTAAGFDVVATAGDGPQAVRRAGAVVPQVLVLDLNLPGMPGVRVCKELVAAQPALRVLVLSASGEHADVLEAVKSGATGYLLKSASTEELTDAVRRTAEGDPVFTPGLAGLVLGEYRRLAVEPAPSAGDEPGAPRLTDRETEVLRLVAKGLSYKQIAERLVISHRTVQNHVQNTLGKLQLHNRVELVRYAIERGLDGS
>NZ_CP045178.1|WP_077969208.1|2000040_2001069_-|6-phosphofructokinase
MRVGVLTGGGDCPGLNAVIRGIVRKGVQEYAYDFTGFRDGWRGALDGATVPLDIPAVRGILPRGGTILGSSRTNPFSEENGVGRLRDTLAEEEIDALIVIGGEDTLGVAGRLWEEHGIPCVGVPKTIDNDLSATDYTFGFDTAVGIATEAIDRLHTTAESHRRVLVVEVMGRHSGWIALHSGLAGGANVILVPERRFDIDEVCAWVTSRFKASYAPIVVVAEGAMPKGGRPVVKDKTLDSFGHIRLSGVGEWLAKEIERLTGHEARTTVLGHVQRGGTPSAFDRWLATRFGLHAIDAVRESDFGKMVALRATDIVRVPITEATAHIKTVDPALYEEVSVFFG
>NZ_CP045178.1|WP_077969207.1|1998794_1999799_-|2-hydroxyacid-dehydrogenase
MEILAFGVQADERPLLEKAFAGLHDLHCLDVFLSEDTAPLAAGHEAISTSVNADLGAHVLRRLAVGGTQFIAQRSTGFNNIDVEVAERLGLTVARVSSYSPYSVAEFAWTLAMSVNRRIVRAAGRTRDFDFRLDGLMGRDLRGRTVGVLGTGKIGEAFTRIAHGFGMRLLGWDVAENPACTALGMSYVDRERLLRESDLISLHVPLLPSTARIIDAEALRLMRDDAILVNSSRGGLVDTEALVAELRAGRFAGVGLDVYEAEAGLFFLDKSLEVVADDTLARLMTFPNVIVTSHQAYYTVDAVNEIIAATVRNVVDYTEGRRGENVLVPAPPRT
>NZ_CP045178.1|WP_077969206.1|1996757_1998680_+|phenazine-specific-anthranilate-synthase
MRTSPAVPPAAPGALVERLRSPGAPPFALLHRRTPGRAKDTVEVLIGPVEEVARLSDIPDADGLPVLALVPFRQIRERGFDVRDDRTPLAVLRAEEAYELPLAEVVDALPSHAVRVEDGAFDVADEEYARTVDRVLREEIGTGEGANFVIRRTFEGRVPGFGGADALALFRRLLTGERGAYWTFVVHTGERALVGASPEAHVRMSGGTVVMNPISGTYRYPQGGPTAEGLLRFLSEKKEIEELSMVVDEELKMMSTVGDMGGVVIGPRLKEMAHLAHTEYELRGRSTLDVREVLRETMFAATVTGSPVQNACRVIERHETGGRGYYAGALALIGRDAGGAQTLDSPILIRTADIDAAGRLRVSVGATLVRGSDPAGEVAETHAKAAGVLAALGVREGRPAAESALPVLADDPRVRAALDGRRSSLAPFWLRMRSEPAAPHGHALIVDCEDTFTAMLAHLLRSSGVGVTVRRYDEPGLREDALTHPGPVILGPGPGDPTDTADPKMRFLRSLAAELLREHRHGLLGVCLGHELIAGLLGLELVRKAVPHQGAQSGVDLFGRRETVGFYNSFTAVCDDEEENELAAHGIEVSRERGAGEVHALRGPGFASVQFHPESVLTLDGVTVVAELLAGALSERVRTM
>NZ_CP045178.1|WP_107502881.1|1996589_1996646_+|trp-operon-leader-peptide
MFAHSTRNWWWTAPPAAR
>NZ_CP045178.1|WP_107502880.1|1995091_1996441_-|3-deoxy-7-phosphoheptulonate-synthase-class-II
MNAENRAGAVEATWRDLPAAQQPEYPDAEALRDVIADLESYPPLVFAGECDQLRARLASVAKGEAFLLQGGDCAESFDAVSAEHIRAKLKTLLQMGAVLTYAASVPVVKVGRIAGQYSKPRSKNTETRDGVTLPTYRGDSVNGFDFTEKARVPDPERLRRMYHASASTLNLVRAFTTGGYADLRQVHAWNQDFVKSSPSGQRYEQLAREIDNALNFMRACGTDPEEFKTVEFFASHEALLLDYESALTRVDSRTGRLYDVSGHMVWIGERTRQLDGAHIEFASRIRNPIGVKLGPSTTPEEALEYIERLDPDREPGRLTFVVRMGADKVRDKLPTLVEKVTASGATVAWVTDPMHGNTFEAASGHKTRRFDDVLDEVKGFFEVHKGLGTHPGGIHVELTGDDVTECVGGGDEIFVDDLHQRYETACDPRLNRSQSLDLAFLVAEMYRDQ
>NZ_CP045178.1|WP_107502876.1|2006940_2007699_-|endonuclease
MPTRTLPDSRTEDDGSAVVRVLSYNIRSMRDDTAALGRVISACAPDLLLVQEAPRFFRWRKYLSRLAMASGMVILTGGGTAAGPALLCSLRATVERTEDILLPLTPGLHRRGLATAVVRFGEARLGVVSCHLSLQKDERYAQGGVVLDRVEALRAEGVAHAVVGGDLNEPPSGRTFRRFADGLQDCWATKPWGGEHTMTPRDPRGRIDALFATDGIEVLGCGVPGPPEVGAADLRVASDHLPVLAALRVPKG
>NZ_CP045178.1|WP_077969212.1|2007795_2008737_-|ROK-family-glucokinase
MGLTIGVDIGGTKIAAGVVDEDGKILNTFTVPTPPTADAIVDAISSAVAGASSGHEIEAVGIGAAGYVDDKRATVLFAPNIDWRHEPLKDKVEQRVGLPVVVENDANAAAWGEYRFGAGQGHEDVICITLGTGLGGGVIIGNKLRRGRFGVAAEFGHIRVVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPENAEILLGLGDGTPETIEGKHISEAARQGDPVAIDSFRELARWAGAGLADLASLFDPSAFIVGGGVSDEGDLVLDPIRRSFRRWLIGGAWRPHAQVLAAQLGGKAGLVGAADLARQG
>NZ_CP045178.1|WP_077969213.1|2008999_2009530_-|hypothetical-protein
MSDPNERPAHDEDAWAEACAEDLAAEQARRRQRYGTPPGSAAEELRKLAETVAEKLTSFQGPAGSAATQQVVRQVVQQAKAVVDPVIERNPQVFDHLAAAGSELLAAYRSAVEGQESRWTRSDDDHVRPTGAGRRETTGDTEDDAGGTTGPTTSTGTETPRRDDEGPGRSDHIDLD
>NZ_CP045178.1|WP_077969214.1|2009901_2011137_-|ArsA-family-ATPase
MRTVLVTGPGGAGRSTVAAAIALAAARRSTRTLLLGADRGGSLQDALGRAVPVGPPAEIAPGLLAARLGSDQRFRDDLLALQDRAGTALDMLGASRLDGDELTPLPGAGELALLRALRDAHTHGAELVVVDLPATPTALATLALPEELRRYLRRLLPPERQAARALRPLLGKLAGVPMPADWLYSTAARWDAELAAVETVLADPGTTVRLVAEPGPAGAEAVRTARTGLALYGLRADALIANRVLPGGGPDEEGPWFSRVAAQQEKTLAEWRAGELPLSELRHLGHDPRGADDLAELAAHAGGPGAAPHAAFAVPGAATAGPWRLTDRRAEEDPEGGTLVWHIPLPGATRDDLDLVRRGDELVVTAGPFRRIVALPSVLRRCAVAGAGLREGELLVRFVPDPTLWPREQPT
>NZ_CP045178.1|WP_077969216.1|2011813_2012644_-|metallophosphoesterase
MHTGAAGAEPGETEARTSGGRTRIHVVSDVHGNVRDLATAGDGADALICLGDLVMFLDYADHSHGIFPDLFGTANADRLVELRTARRFAEAGEFGRALWAELGEAPGPAVERAVRGQYTELFAAFPTPTYATYGNVDLPTLWPEFARPGTTVLDGERVEIAGRVFGFVGGGLRTPMRTPFEISDEEYAAKIEALGEVDVLCTHIPPEIPELVYDTVARRFERGSRALLAAIRKTRPRYSLFGHVHQPLARRVRIGPTECVNVGHFASTGRPWALEW
>NZ_CP045178.1|WP_077969217.1|2012963_2014760_+|long-chain-fatty-acid--CoA-ligase
MREFSLPALYEVPADGNLTDIVRRNAVRHPDVAVLGRKVDGGWQDVTARVFQNEVRAAAKGLIASGVRAGDRVALMSRTRYEWTLLDFAIWSAGAVTVPVYETSSAEQVQWILEDSGAVACLVETDTHAAVLDSLRERLPDLARVWQIDRDGVAELGRAGADLSDEAVEERSSVAGADDPATLVYTSGTTGRPKGCVLTHRSFFAECGNVVERLKPLFRTGECSVLLFLPVAHVFGRLVEVAALMAPIKLGHAPDVKNLTDELASFRPTLILGVPRVFEKVYNAARAKARADGKGRIFDRAADTAIAYSRALDTPAGPSLGLRIRHRVLDKLVYGKLRAVLGGRGEYAISGGAPLGERLGHFFRGIGFTVLEGYGLTESCAATAFNPWDRQKIGTVGQPLPGSVVRIADDGEVLLHGEHLFARYWNNEAATAEALADAWFHTGDIGTLDEDGYLAITGRKKEIIVTAGGKNVAPAVMEDRVRAHALVAECMVVGDGRPFVGALITLDGEFLGRWAEEHGKPADATPASLREDPELLAEIQRAVDDGNAAVSKAESVRKFRVLAAEFTEDSGHLTPSLKLKRNVVAKDYAGDIEALYHG
>NZ_CP045178.1|WP_077969218.1|2014835_2015978_-|glycosyltransferase-family-4-protein
MHKTLIVTNDFPPRPGGIQAFLHNMALRLDPEQLVVYASTWKRGQEGADATAAFDAEQPFTVVRDRTTMLLPTPRVTRRAVRLLREHGCTSVWFGAAAPLGLMAPALREAGARRLVATTHGHEAGWAQLPAARQLLRRIGESTDTVTYLGEYTRSRIAGAFSPEAAARMVQLPPGVDEKTFHPASGGAEIRAGLGLTDRPVVVCVSRLVPRKGQDTLILAMKRILAARPDTVLLIVGGGPYEKELRRLADRTGVADSVRFTGAVPWALLPAHYGAGDVFAMPCRTRRGGLDVEGLGIVYLEASATGLPVVAGDSGGAPDAVLDGETGWVVRGGSSEEAADRIVTLLGDAELRRRMGERGRAWVEEKWRWDLLAGKLRELL
>NZ_CP045178.1|WP_077969219.1|2016156_2017422_+|DUF2029-domain-containing-protein
MAGRAAGPSVVRTLAVWALTRAVLMLCVLKVLTVPGPDVTSDVSVIYRNWFDILRTGTFPLGDVTWQYPPGAALPILSPGLLPSVGYAEAFFALVLICDALVMAALLYAAHGRGRRSAGVWVWVVGVPLLGPTVYARYDVMVTAVAVAALLAGSRHPRVMGALTAFGAMLKVWPVLLLIGTARREATRRSWGTAVLVALGLLGVFALSMPGSLSFLTFQRERGTEVESLGSLVFHVARRFGWQGTVQFHYGSVEFVGPYVPLVSTLAQLLSVVALGWLVVWRLRARVWTPSTLADAGFTAVLLFTATSRVISPQYMVWLVGCAAVCLLFRSSRMGPPACLILAATAVTLLEFPIWFGHVVGSDDLGITLLFVRNGLLVTAAVIACLRLWRQTVTEPAASEASDAVAPARGAAEGRDDLVET
>NZ_CP045178.1|WP_107502877.1|2017458_2018649_-|hypothetical-protein
MLCCALVAGCGGPALSGAGRPAEDAAVRRLLDRRAQAVTGADEEDYLATVDPDDKAAIRRERRTFENLDAVPLTSWEYRLTGFDRSGKERGTAAVELRYRLDGYDTAPVSAARTVTLDRRAGRWYVTGERPAAKAPGQLWEQGDVRVTKGADAIVLGVGRDADALREYARLADRAVAAVHRAWDRPWPRRLVVLVPASLQGMASLLGAPASDYRGIAAVTTGEVGGTAKTPADRIVVNPEAYGVLGDLGKQVVLTHEATHVATRAQTSAATPLWLSEGFADWSGYRGTGRTAAQAAPELHTAVRSGRLPAALPDDKEFGFASDADRLAQAYEGGWLACRMIAEQWGEAKLRDFYAAVGAHEERTGAVEAALRDVLGTGTEEFTAQWRDYVREQLGS
>NZ_CP045178.1|WP_077969221.1|2018734_2019763_-|C40-family-peptidase
MGSHRRLAPSGCDRSTRATVLGAAAATAAAALTATPATAEPHDTRAGTRAQVDRLFEQAEKATEAFNKADERADKLREQVGHVKDAVAKSQERINTMRGAIGALAGAQYRSGGVDPSLALLLSSDPDSFLDRAAALGRVNNHHASELSGLIKAQRGLSQDRAEATRMLAELDKSRTEVARHKRSVEHRLSAARRLLNSLPEKERDDHGRSSRSDEAGRHDLAGSAAPSGRASSALAAARQAIGSPYVWGANGPSRFDCSGLTQWAWSRAGVSLPRTSQAQASAGHSVPLSQARPGDLVAYRDDASHIGMYAGGGQVIHAPYPGAQVRYDPVGMMPISSITRP

Crispr_ID: NZ_CP045178_5

• CRISPR_ID: NZ_CP045178_5
• CRISPR_location: 2420956-2421076
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_5

Consensus_repeat	Method
CGTGTCGCGGGGTCACCCCGTTCCGTGTC	CRISPRCasFinder

spacers of NZ_CP045178_5

>5.1|2420985|63|NZ_CP045178|CRISPRCasFinder
GCGGAGTGGCCCCGTTCGTGTCGCGGGGTCACCCCGTTCCGTGTCACGCGAGTCGCCTCGTTC

CRISPR arrays and Neighbor proteins around NZ_CP045178_5

CRISPR arrays

The CRISPR arrays of NZ_CP045178_5

>merge|NZ_CP045178|5|2420956-2421076|CRISPRCasFinder
AGTGACGTGGCTTCATCCCGTTCCGTGTCGCGGAGTGGCCCCGTTCGTGTCGCGGGGTCACCCCGTTCCGTGTCACGCGAGTCGCCTCGTTCCGTGTCGCGGGGTCACCCGTTCCGTGTCG

>NZ_CP045178|5|3|2420956-2421076|CRISPRCasFinder
AGTGACGTGGCTTCATCCCGTTCCGTGTC	GCGGAGTGGCCCCGTTCGTGTCGCGGGGTCACCCCGTTCCGTGTCACGCGAGTCGCCTCGTTC
CGTGTCGCGGGGTCACCCGTTCCGTGTCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077967179.1|2403117_2403894_+|cyclase-family-protein	unknown	unknown	gnl|CDD|224790
NZ_CP045178.1|WP_077967153.1|2430659_2431862_-|ROK-family-protein	unknown	unknown	gnl|CDD|224851
NZ_CP045178.1|WP_077967161.1|2423130_2423910_-|TSUP-family-transporter	unknown	unknown	gnl|CDD|182593
NZ_CP045178.1|WP_077967163.1|2422183_2422906_+|class-F-sortase	unknown	unknown	gnl|CDD|320678
NZ_CP045178.1|WP_107502779.1|2417600_2419052_-|deoxyguanosinetriphosphate-triphosphohydrolase	unknown	unknown	gnl|CDD|235098
NZ_CP045178.1|WP_077967175.1|2408246_2409980_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP045178.1|WP_077967155.1|2425911_2426844_+|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235737
NZ_CP045178.1|WP_077967176.1|2406280_2407738_+|sugar-kinase	unknown	unknown	gnl|CDD|198375
NZ_CP045178.1|WP_077967159.1|2424076_2424661_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP045178.1|WP_077967167.1|2419825_2420599_-|NADPH-dependent-FMN-reductase	unknown	unknown	gnl|CDD|377026
NZ_CP045178.1|WP_077967151.1|2433786_2435721_+|aminotransferase	unknown	unknown	gnl|CDD|225942
NZ_CP045178.1|WP_077967146.1|2435809_2436949_-|tRNA-dihydrouridine-synthase-DusB	unknown	unknown	gnl|CDD|129820
NZ_CP045178.1|WP_077967174.1|2409979_2411905_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP045178.1|WP_077967171.1|2414074_2415991_-|DNA-primase	unknown	unknown	gnl|CDD|235551
NZ_CP045178.1|WP_077967170.1|2416042_2417326_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|170080
NZ_CP045178.1|WP_077967289.1|2427284_2430092_-|pyruvate,-phosphate-dikinase	unknown	unknown	gnl|CDD|236446
NZ_CP045178.1|WP_077967178.1|2405177_2405474_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077967157.1|2424812_2425622_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|235500
NZ_CP045178.1|WP_107502780.1|2412103_2413279_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|235640
NZ_CP045178.1|WP_077967165.1|2421326_2421899_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077967179.1|2403117_2403894_+|cyclase-family-protein	gnl|CDD|224790	COG1878, COG1878, Kynurenine formamidase [Amino acid transport and metabolism].	4.61058e-32
NZ_CP045178.1|WP_077967153.1|2430659_2431862_-|ROK-family-protein	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.25819e-43
NZ_CP045178.1|WP_077967151.1|2433786_2435721_+|aminotransferase	gnl|CDD|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	8.80491e-75
NZ_CP045178.1|WP_077967161.1|2423130_2423910_-|TSUP-family-transporter	gnl|CDD|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	3.01619e-32
NZ_CP045178.1|WP_107502779.1|2417600_2419052_-|deoxyguanosinetriphosphate-triphosphohydrolase	gnl|CDD|235098	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	0
NZ_CP045178.1|WP_077967175.1|2408246_2409980_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	8.39559e-159
NZ_CP045178.1|WP_077967155.1|2425911_2426844_+|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|235737	PRK06197, PRK06197, short chain dehydrogenase; Provisional.	4.92344e-115
NZ_CP045178.1|WP_077967176.1|2406280_2407738_+|sugar-kinase	gnl|CDD|198375	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases. This subgroup is composed of D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17) from bacteria and eukaryota. They share high sequence similarity with Escherichia coli xylulokinase (EcXK), which catalyzes the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. Some uncharacterized sequences are also included in this subfamily. EcXK exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ might be required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	7.86469e-112
NZ_CP045178.1|WP_077967159.1|2424076_2424661_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	5.97646e-10
NZ_CP045178.1|WP_077967167.1|2419825_2420599_-|NADPH-dependent-FMN-reductase	gnl|CDD|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	4.85135e-44
NZ_CP045178.1|WP_077967146.1|2435809_2436949_-|tRNA-dihydrouridine-synthase-DusB	gnl|CDD|129820	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family. This model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily.The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus.Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase. [Unknown function, General].	2.7511e-131
NZ_CP045178.1|WP_077967174.1|2409979_2411905_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
NZ_CP045178.1|WP_077967171.1|2414074_2415991_-|DNA-primase	gnl|CDD|235551	PRK05667, dnaG, DNA primase; Validated.	0
NZ_CP045178.1|WP_077967170.1|2416042_2417326_-|FAD-dependent-oxidoreductase	gnl|CDD|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	2.79361e-73
NZ_CP045178.1|WP_077967289.1|2427284_2430092_-|pyruvate,-phosphate-dikinase	gnl|CDD|236446	PRK09279, PRK09279, pyruvate phosphate dikinase; Provisional.	0
NZ_CP045178.1|WP_077967163.1|2422183_2422906_+|class-F-sortase	gnl|CDD|320678	cd05829, Sortase_F, Sortase domain found in the class F family of sortases. Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.	1.24056e-53
NZ_CP045178.1|WP_077967157.1|2424812_2425622_+|SDR-family-oxidoreductase	gnl|CDD|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	1.35596e-62
NZ_CP045178.1|WP_107502780.1|2412103_2413279_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	2.29279e-160

Protein sequences

>NZ_CP045178.1|WP_077967167.1|2419825_2420599_-|NADPH-dependent-FMN-reductase
MDTKTDNQAPTTSAPTTSAPTTSASTPAPAPATSTPTLVTPLSTLAAESGPLTTSAAQEAREDRRPTPLRVAVIIGSNREGRFGPVVAEWLLAHVRDHGDLESTVIDLADTELPTSLTSTPSPAVAAELAKTSPALAAADAFLILTPEYNHSFPASLKSLIDWHFVEWQAKPVAFVSYGGISGGLRAVEQLRPVFAEMHAVTVRDTVSFHNAHALFDEHGRHRQPEAPDTAAEAMLDQLTWWGYALRDAKETRPYGG
>NZ_CP045178.1|WP_107502779.1|2417600_2419052_-|deoxyguanosinetriphosphate-triphosphohydrolase
MPPRAPEARTDGPGHDDGRAHTDVRGHDDGRARTDTRGHDDGRRCDDARGYADAHGEEDSAAATERWAPEPDKRPGRTAFQRDRARVLHSSALRRLSGKTQVVTPGTRSRVWDASPRTRLTHSLECAQVGRELGAALGCDPDLVETACLAHDLGHPPFGHNGEQALNEVAADCGGFEGNAQSLRLLTRIEPKRFINSGPDNMQVSVGLNLTRASLDAATKYPWTRGGHPTDPDSVKFGVYEDDVPVFAWARRGAPAHTTCFEAQVMDWADDVAYSVHDFEDGLHAGHIDTAALSSAPERAEIWSVAIDRYVPADTDPQELSAALDRLTAQPWWPHGYDGSAPAQGRLKDATSQLIGRFCQHAETATREEYGTGRLTRYAARLVVPRSVRMECAVLKAVADLYVMQRVEQEVLRADQRIVVAELAAAMVARAPHGLDPQFAALFESAADDRARKRVVVDQIASLTDASARVLHAELTGANGGAR
>NZ_CP045178.1|WP_077967170.1|2416042_2417326_-|FAD-dependent-oxidoreductase
MVDAHQTFVIVGGGLAGAKAAETLRAEGFTGRVILVCDERDHPYERPSLSKGYLLGKEERDSVFVHDPAWYAGADVELHLGQPAVQLDRAEHTVTLGDGTLLRYDKLLLATGSEPRRLDIPGTDLAGVHHLRRLAHAERLRRVLATLGRDNGHLLIAGGGWIGLEVAAAARGYGAEVTVVEPQATPLHQAVGPEVGRLFADLHRDHGVRFHFGASLTEISGQDGMVLAAHTDDGEEHPAHDVLAAIGAAPRTALAEAAGLTLAGPDAGGGISVDTSLRTSDPDIYAAGDVASVPLAFFPGADQHGTPLRVEHWANALNGGPAAARAMLGQDVTYDRVPYFFSDQYDVGIEYSGYAPPGSYDQVLIRGDAGKRQFIAFWLSEGRVLAGMNVNVWDVTGPIQELIRSGARPDPHALADPSIDFASLPMD
>NZ_CP045178.1|WP_077967171.1|2414074_2415991_-|DNA-primase
MAGRINDEDVKAVRDAVPIDAVVSEYLQLRNAGGGNLKGLCPFHDEKSPSFQVSPSKGLFHCFGCQEGGDTITFVMKIDHLSFSEVVERLAGQAGITLRYEEGGYNPASQRGERIRLVEAHKIAAQFYEEQLGGAEAEIGRKFLAERGFDQAAAHHFGVGYSPAGWDHLTRFLRGKGFSDTELILSGLSQDGRRGPIDRFRGRLMWPIKDIGGEVVGFGARKLRDDDNGPKYLNTPETPIYRKSQVLYGIDLAKKEIAKTSRAVLVEGYTDVMACHLSGITTAVATSGTAFGVDHIKILRRLLMDNGSARVIFTFDGDAAGQKAALRAFEDDQKFAAETYIAVAPDGMDPCDLRLTKGEEAVRELVEPRVPLFEFALRQIVSRYDLETPAGRAAALDEAAPVVARIKNTASQHEVAVQLAGMLGILDTQFVVRRVGQIARWARGKGQGGDSERGGRGPQQQGRTPESFETPRPPSGPALNLRSPAHRTERELLKLALQRPELVSPAFDAYGVDEFTAPPYAAVRQTIEEAGGAEEGVRDATEYLTRVRETAPDDTVRAMVTELAVEAILCKSVDEVYAGEQLVRVRQRAVERRVRDVQGSLTRLGSGGDPAKAAVVQNELWVLQQYGKALKDQGAAAL
>NZ_CP045178.1|WP_107502780.1|2412103_2413279_-|sigma-70-family-RNA-polymerase-sigma-factor
MTAPPPRRPVPESPEAGTTARPMAPPEPVRPEAGPDQPPHVAPVPPEPAGGRRGAGPQLEEAPVRPSPEDETDDRVDLPAPRLRGDASGISSDLFRQYLREIGRIPLLTAAGEVDLARRVEAGLFAEERLAGSSDLDSRLALDLDRLVVLGRMAKRRLIESNLRLVVSVAKRYVGRGLTMLDLVQEGNLGLIRAVEKFDYTRGYKFSTYATWWIRQAMSRALADQARTIRVPVHVVELINRVVRVQRRLLQERGYEPTHEEVAAQLDLLPARVGEVLRLAQEPVSLHAPVGEEDEVALGDLIEDSDAASPVESAAFLLLREHLEAVLSTLGERERKVVQLRYGLVDGRPRTLEEIGGIFGVTRERIRQIESKTLNKLRDHTFADQLRGYLD
>NZ_CP045178.1|WP_077967174.1|2409979_2411905_+|ABC-transporter-ATP-binding-protein
MAGPGGRMAAGASGQRSMDFKGSSTRLLSRFKPERGTLWLMLTAAVLSVACSVIGPKILGRATDLIFGGIIGRGMPSGLTKDQAVRAARERGDGRTADLLSGMDFTPGKGIDFDRIGTVLLLALVMFLAAGLLMAVSTRLSNRVINRVVFRMREDVQTKLSRLPLSYFDKRQRGEVLSRATNDIDNISQTLQQSTGQLVNSLLTIVGVLVMMFWISPLLALVALVTVPLSALVAARVGKRSQPQFVRQWRTTGKLNAHVEEMYTGHALVKVFGRQEESAKSFAEQNEALYEAAFKAQFNSGIMQPLMMFVSNLNYVLVAVVGGLRVASGALSIGDVQAFVQYSRQFSQPLTQVASMANLIQSGVASAERVFELLDADEQSADPVPAERPDVVRGRVELEHVSFRYEEDKPLIEDLSLAVEPGHTVAIVGPTGAGKTTLVNLLMRFYDVTAGRITLDGVDIARMTRDDLRAGIGMVLQDTWLFGGTIAENIAYGAPKDVTREQIEEAAAAAHADRFVRTLPEGYDTVIDDEGTGVSAGEKQLITIARAFLSDPVILVLDEATSSVDTRTEVLIQKAMAKLAHGRTSFVIAHRLSTIRDADTILVMENGSIVEQGTHDDLLSAEGAYARLYAAQFAQAVAEVD
>NZ_CP045178.1|WP_077967175.1|2408246_2409980_+|ABC-transporter-ATP-binding-protein
MLIRLLRSYLSPYKRPIALLVLLQLIQTSAALYLPTLNADIIDKGVVKGDTGYILALGAVMLGVTLVQMVGNIGAVYLGARTASALGRDVRAAVFDRVQSFSAREMGQFGAPTLITRTTNDVQQVQMLVVMTFTLMVSAPIMCVGGIVMALGQDIPLSGILLAVVPVLAVSVSLIVRRMRPLFRSMQKRLDTVNRVLREQITGNRVIRAFVRDAYEGTRFEGANTELTDVSLKTGRLMALMFPIVMTVVNVSSIAVVWFGAHRIDSGGMEIGALTAFLSYLMQIVMSVMMATFMFMMVPRAEVCAERIEEVLGTSSSVVPPVAPVVELRSHGHLEVRAAGFRYPGAEEPVLREVSLVAKPGEITAVIGSTGSGKSTLLGLVPRLFDATDGEVLVDGVDVRTVEPALLARTVGFVPQKPYLFSGTVATNLRYGNPDATDEELWHALDVAQARGFVEGLDGGLDAPVAQGGTNVSGGQRQRLAIARTLVRRPEIYLFDDSFSALDYATDAALRAALAEETARATVVIVAQRVSTIRDADRIVVLDEGRVVGTGRHRELMEGNETYREIVLSQLTEAEAA
>NZ_CP045178.1|WP_077967176.1|2406280_2407738_+|sugar-kinase
MGIVAGLDSSSEFTRIVVCDADTGAVLRQGHAPHPAGPEGGAPSDVDPQVWLLSLGEAAAGGLLEGVQAIGVSAQAHALVPLDGQGATVRPAMTGNDKRAQATAADLVDTLGGRQAWAEAVGCVPRAGQPVTKLRWLAKHEPESAHRTTALLQAHDWLVWQLLGRPARRTTDRGGASGTGYWSAATGAYRPELVELALGHTAALPEVIGPSDTAGTTPEGLLISAGTGETMAAAFGLGVRQGDAVVSLGASGSVMGVHHEALADSDGMITSLADATGMHLPVVHTQNAVRALRGTADMLSTDLEGLSDLALKSTPGAHGLVLLPYLEGERTPSLPHTAGTLSGLRRESMKPEHLARASFEGMLCSLADALGVLRGRGVEVRRVFLLGAAAELPAVQAVAPALFGAQVVVVQPADYAAIGAARQAAWALGVSQGTLDPQSPPAWQGAAAQVLDPGEELPVGQAVRQQYAAVRDQVHPQAFGAAHLG
>NZ_CP045178.1|WP_077967178.1|2405177_2405474_+|hypothetical-protein
MRYRLTFVVGVALGYVLGTRAGRERYEQLRKSARQISQNPAVRNVTESAAQQGRAAAGKALHTVSERVGDRMPESVSQRVRTLRGRTGGEDDWGTSAT
>NZ_CP045178.1|WP_077967179.1|2403117_2403894_+|cyclase-family-protein
MRFIDLSTPIDATAWEPEPVEHQVMSAADGAKHMSEEMRTHFGVEFDPSVLPGGELLSIDTLSLTTHTGTHIDAPSHYGSVATYGDGRPRHIDELPLEWFHGPGVVLDLTGAGPGAVDAAFVRQQLDRIGHVVSAGEIVLLRTGASRLSGTPAYFTDFTGLDGSATHYLLDQGVRVIGTDAFSLDAPFRHMIEHYQRTGEAGALWPAHFAGRDREYCQIERLAHLESLPAPTGFDVSCFPVKIAGAGAGWTRAVALLP
>NZ_CP045178.1|WP_077967165.1|2421326_2421899_+|hypothetical-protein
MPTARLLTGTALAAAAAGLTVVPAYAGAEEPSGSAARQGALQMSPSTVVPGATVLVNTAACGSRATATGDAAAVGSGSFALAPSTRPEDARGKFRVPPSAQPGTYEIVAKCSDGTSVAGDLMVTLQGAQGAQGAAADVAPPMAPRGHVRTGVGGALGTDPVRTAAGVAALAVAAAGGTWLLHRRARGDRI
>NZ_CP045178.1|WP_077967163.1|2422183_2422906_+|class-F-sortase
MASESHPIAGPNSPCADTSCDGAGTAPARREVGGLRAGTVAAGVVTLLALGSGLWLLRSGSDTHAPPQPSAAQAVAPGQRARDAAPALAPSAPDRIRIPSIDVDAPMMGLALTAGGSLGVPPPQKSEVAGWYEAGTTPGENGTAVVAGHVDNAKGPAVFYSLGALTKGSTIEVARRDGTIAVFTVDAVELYSARHFPDHKVYGPSPRPELRVITCGGGYSKETGYQGNVVVFAHLTGSKP
>NZ_CP045178.1|WP_077967161.1|2423130_2423910_-|TSUP-family-transporter
MYDISLTTVVVLCLAAGAAGWIDAVVGGGGLLLLPALLIGAPHVAPASILGTNKAVAVVGTSAAAVAYARKVPVGLGRALRIGVAALCGSMCGAFFAAGIDSAVMRPMIMVVLLAVLAFVMFRPAFGTAPATGPAGRGRNVTAVLVVGIGLGLYDGLIGPGTGTFLVLALTAVLHLDLVHASATAKIVNVCTNLGALAMFAYHGTVLWQLAAPMAACSLAGGLAGARTALKRGSGFVRAVLVVVVVSLVAKLAYDQWVA
>NZ_CP045178.1|WP_077967159.1|2424076_2424661_+|TetR/AcrR-family-transcriptional-regulator
MPRTKEFDPDAALQSALELFWRRGYEATSMADLVAHLGIGRASVYATFGSKHELYLRALDRYIEAQDPVLIRELSAPGPALPAVRSLVLRFAEEAGAAPTRAQGCLVTNTATELGPHDTAAARRVEESWARVETLLHSALVRAQAQGELPQERDARALARMLLILMQGIRVAGKVPAQPSRVRDAAEQALMLLS
>NZ_CP045178.1|WP_077967157.1|2424812_2425622_+|SDR-family-oxidoreductase
MSTKTSTAPRTAASPASAPFADRTVLVTGAGAGIGRAVALAFAAGGASVAVAGRTPASLEETTALIAAAGGTAAAFTADVSDADSTRALVAAVVDRFGSLDIAVNNAGVFRGGAPLAELSDSDWRTLLDINVTGVFNSLRAEVELMRGQDDGGVIVNIASNLGAHSRSAGKTAYAMSKAAVSALSRGAALDHIGDGVRINAVSPGPVATTMSLMPGESEAERVVRMKEQSPLGRVSTLEEVAAAVLHLASPAAASFVGADLVIDGGATA
>NZ_CP045178.1|WP_077967155.1|2425911_2426844_+|SDR-family-NAD(P)-dependent-oxidoreductase
MSGWNASDIPDQSGRTAVVTGANSGIGYVTARELARNGARTVLACRDATRGGDAVARLLSEVPGAHAELGLLDLGDLSSVREFAAAHRERPLDLLVNNAGVMALPHTRTADGFETQFGVNHLGHFALTGLLSPALLATPGSRVVTVSSGLHVLSNIDLNELNSEHGYRRWIAYGRSKTANLLFTHELARRLAAAGSGTVAAAAHPGYALTNLQTTGVRMEGRKAAERVVGLANRVVGQSAEMGALPSLYAATAPGVLPDSFTGPRYAMWRGEPASSWRAPWTLNDTAGELLWTASEKLTGVTYDALKVQK
>NZ_CP045178.1|WP_077967289.1|2427284_2430092_-|pyruvate,-phosphate-dikinase
MSSHSKTTDTPKSARPSGETRKTGRKAAAKSGTAGTATPKFVYDFREGNRDLKDLLGGKGANLAEMTNLGLPVPPGFTITTEACRTFLESGEEPPALRDEVSAHLAALESEMGKRLGQADDPLLVSVRSGAKFSMPGMMDTVLNIGLSDASVAGLAAQAGDERFAWDSYRRLIQMFGKTVLDIDGDLFEEALEEVKRAKKAATDVELGADDLKKLVKRYKKIVADGAGREFPQDPREQMDLAVKAVFASWNGDRAKLYRRQERIPHDLGTAVTICSMVFGNLGPDSGTGVAFTRDPASGHQGVYGDYLQNAQGEDVVAGIRNTVALADLESVDKASYEQLMEIMATLENHYLDLCDIEFTIERGKLWMLQTRVGKRTAGAAFRIATQLVDQGLIDEAEALQRVNGAQLAQLMFPRFDEDATVEMIGRGIAASPGAAVGRAVFDSYTAIKWSRSGEKVILIRRETNPDDLDGMIAAEGILTSRGGKTSHAAVVARGMGKTCVCGAEELEVDTKQRRLTMAGGRVVEEGDTVSIDGSSGKVYLGEVPVVPSPVVEYFEGRMHAGADEADELVAAVHRIMAYADRVRRLRVRANADNAEDALRARRFGAQGIGLCRTEHMFLGERREMVEKLILADTDSEREQALKALLPLQKKDFVELFEAMDGLPVTVRLLDPPLHEFLPDITELSVRVALAESREDPNENDLRLLQAVHRLHEQNPMLGLRGVRLGLVIPGLFTMQVRAIAEAVAERKATKGDPRAEIMIPLVGTVQELEIVKDEAEQVISEVEAATGASLKLSLGTMIELPRAALTAGQIAEAAEFFSFGTNDLTQTVWGFSRDDVEASFFTAYLEKGIFGVSPFETIDRDGVGKLVADAVKAGRATRPELKLGVCGEHGGDPESVHFFHDVGLDYVSCSPFRIPVARLEAARAAARPTGDTTR
>NZ_CP045178.1|WP_077967153.1|2430659_2431862_-|ROK-family-protein
MAGNQANAGDLLQLVRSGRATTRGALQQVTGLSRATVGQRLDRLFRAGWLREGRGGEVGSPLGGRPSARLEFDDTHAVVLVADLETRHGRAAVLGLSGEALAEYTGELRVEDGPDVVLGELGAWFGRLLGSAGVPASSVCGIGLAVPGPVDRSTGRVVQPPIMPGWDGYDMEGRLRRAFSEATGRAAPVPVLVENDANLMAYGEQRATHPDCAAFVLVKVSTGIGAGVVVGGAIYRGVDGGAGDIGHIRIAGGADALCECGSQGCLAAVAGGRALARRLTAAGVPASSGSDIRALLAAGHPEAMGLAREAGRHVGDVLATVVTLLNPGVLMIAGDLAGTPFLTGVRELLYQRALPRNTAHLNVVTSRLGDRAALVGAGALVVEHLYGAERAEERLAAMGI
>NZ_CP045178.1|WP_077967151.1|2433786_2435721_+|aminotransferase
MTERQHHLLVHGGTFAALDGAGDITGVRGTSPDGLFVRDARHLSRWQLTADGAVPEVLLPASGGETLRTVLTPRGSRDEPPPYTLFREQAVTEGAFVETLRVVNNRSVPLSVRIVLTVDADFTDQFELRSDRRTYTKIGAVRRREAVEGGIEFGYRRGDWRSRTTVTAEPAPDGVEETGTGARRLVWDLEPEAHGTVELDVRVLAHPHGGAGHPEAPGSPRSLERELAGRSERYARGVELSTAWPELSAVCSRGLSDLAALQVPAEGPDGEELRVPGAGVPWFVALLGRDALLTSLFLLPYLPGPAAATLAALAAAQATEDESGLAEPGKIVHEVRHGELAHFGQVPFGRYYGSVDATPLFLVLLGAYTERTGDPALARRLEPQARAAVGWMLDHGGLGSRGYLVYRADEGGLANQNWKDSPGAICCADGSRPTGEVMAAGAQGYAYDALRRTAQLARTVWSDAKYADRLERSAAGLRDRFQRDFWMEEQAFPALALDGAGRQIDALASDAGHLLWSGLLDKEYGEVVGRRLLEADFFSGWGVRTVAAGQPAYHPLSYHRGSVWPHDNALIALGLARYGLHDEARAVAHALVEAAVRDGDRLPEVLAGYGRETHPEPVPYPHACARESRSASAPLALLTAVGEV
>NZ_CP045178.1|WP_077967146.1|2435809_2436949_-|tRNA-dihydrouridine-synthase-DusB
MSTALPSLKIGPHTASPPVVLAPMAGITNAPFRTLCREFSGGKGLFVSEMITTRALVERNEKTMQLIRFGPTEQPRSIQLYGVDPATVGKAVRMIADEDLADHIDLNFGCPVPKVTRKGGGSALPYKRNLLRAILREAVTGAGDLPVTMKMRKGIDDDHLTALDAGRIAVDEGITAIALHGRTAAQHYAGTADWDAIARLKAHVPEIPVLGNGDIWSADDAVRMMRETGCDGVVVGRGCLGRPWLFSDLVAAFEGGAASAAPPLREVAAVMLRHATLLGEWLGDEARGVIDFRKHVAWYLKGFSVGSEMRRRLAVTSSLAELEDGLAELDLDQEWPVGAEGPRGRTSGKNRVVLPDGWLNDPYDCAGLSEDAELDTSGG

Crispr_ID: NZ_CP045178_6

• CRISPR_ID: NZ_CP045178_6
• CRISPR_location: 2947461-2947591
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP045178_6

Consensus_repeat	Method
CTGCTCCGGCCCACCGGGCTGGTGCG	CRISPRCasFinder

spacers of NZ_CP045178_6

>6.1|2947487|28|NZ_CP045178|CRISPRCasFinder
CATGCTCGGAACCACCGGTCTGCACCGG
>6.2|2947541|25|NZ_CP045178|CRISPRCasFinder
TCAGGGGCCCTTGCCCCGCCGTGCC

CRISPR arrays and Neighbor proteins around NZ_CP045178_6

CRISPR arrays

The CRISPR arrays of NZ_CP045178_6

>merge|NZ_CP045178|6|2947461-2947591|CRISPRCasFinder
CCGCTCGGAACCCCCGGCCTGGCCCGCATGCTCGGAACCACCGGTCTGCACCGGCTGCTCCGGCCCACCGGGCTGGTGCGTCAGGGGCCCTTGCCCCGCCGTGCCCTGCTCCGGCCCACCGGGCTGGTGCG

>NZ_CP045178|6|4|2947461-2947591|CRISPRCasFinder
CCGCTCGGAACCCCCGGCCTGGCCCG	CATGCTCGGAACCACCGGTCTGCACCGG
CTGCTCCGGCCCACCGGGCTGGTGCG	TCAGGGGCCCTTGCCCCGCCGTGCC
CTGCTCCGGCCCACCGGGCTGGTGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077969546.1|2961108_2961423_-|hypothetical-protein	unknown	unknown	gnl|CDD|274862
NZ_CP045178.1|WP_077970080.1|2863668_2864604_-|RICIN-domain-containing-protein	unknown	unknown	gnl|CDD|379501
NZ_CP045178.1|WP_143621349.1|2962570_2962840_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970069.1|2847278_2849708_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969551.1|2949717_2953812_-|type-VII-secretion-protein-EccCa	unknown	unknown	gnl|CDD|274858
NZ_CP045178.1|WP_077969566.1|2963707_2963881_+|CsbD-family-protein	unknown	unknown	gnl|CDD|283241
NZ_CP045178.1|WP_077970087.1|2861631_2863485_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP045178.1|WP_077970073.1|2853429_2854260_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969549.1|2954808_2955447_+|hypothetical-protein	unknown	unknown	gnl|CDD|227596
NZ_CP045178.1|WP_077970076.1|2855559_2856423_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970071.1|2849707_2853217_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970075.1|2854363_2855563_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969567.1|2956497_2959362_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|163057
NZ_CP045178.1|WP_143621365.1|2856490_2857630_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969547.1|2959633_2960980_-|hypothetical-protein	unknown	unknown	gnl|CDD|378057
NZ_CP045178.1|WP_077969548.1|2955608_2956421_-|hypothetical-protein	unknown	unknown	gnl|CDD|274862
NZ_CP045178.1|WP_107502927.1|2864756_2865521_-|type-VII-secretion-system-associated-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969545.1|2961513_2961897_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|377587
NZ_CP045178.1|WP_077970078.1|2857990_2860705_-|protein-kinase/lanthionine-synthetase-C-family-protein	unknown	unknown	gnl|CDD|271199
NZ_CP045178.1|WP_077969550.1|2953940_2954603_-|hypothetical-protein	unknown	unknown	gnl|CDD|274862

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077969546.1|2961108_2961423_-|hypothetical-protein	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.51415e-05
NZ_CP045178.1|WP_077970080.1|2863668_2864604_-|RICIN-domain-containing-protein	gnl|CDD|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	5.34691e-14
NZ_CP045178.1|WP_077969551.1|2949717_2953812_-|type-VII-secretion-protein-EccCa	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP045178.1|WP_077969566.1|2963707_2963881_+|CsbD-family-protein	gnl|CDD|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	0.00199977
NZ_CP045178.1|WP_077970087.1|2861631_2863485_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.49547e-80
NZ_CP045178.1|WP_077969549.1|2954808_2955447_+|hypothetical-protein	gnl|CDD|227596	COG5271, MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only].	0.00232897
NZ_CP045178.1|WP_077969567.1|2956497_2959362_-|AAA-family-ATPase	gnl|CDD|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	3.42803e-80
NZ_CP045178.1|WP_077969547.1|2959633_2960980_-|hypothetical-protein	gnl|CDD|378057	pfam08817, YukD, WXG100 protein secretion system (Wss), protein YukD. The YukD protein family members participate in the formation of a translocon required for the secretion of WXG100 proteins (pfam06013) in monoderm bacteria, with the WXG100 protein secretion system (Wss). Like the cytoplasmic protein EsaC in Staphylococcus aureus, YukD was hypothesized to play a role of a chaperone. YukD adopts a ubiquitin-like fold. Usually, ubiquitin covalently binds to protein and flags them for protein degradation, however conjugation assays have indicated that the classical YukD lacks the capacity for covalent bond formation with other proteins. In contrast to the situation in firmicutes, YukD-like proteins in actinobacteria are often fused to a transporter involved in the ESAT-6/ESX/Wss secretion pathway. Members of the YukD family are also associated in gene neighborhoods with other enzymatic members of the ubiquitin signaling and degradation pathway such as the E1, E2 and E3 trienzyme complex that catalyze ubiquitin transfer to substrates, and the JAB family metallopeptidases that are involved in its release. This suggests that a subset of the YukD family in bacteria are conjugated and released from proteins as in the eukaryotic ubiquitin-mediated signaling and degradation pathway.	2.43695e-13
NZ_CP045178.1|WP_077969548.1|2955608_2956421_-|hypothetical-protein	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	0.00481099
NZ_CP045178.1|WP_077969545.1|2961513_2961897_-|WXG100-family-type-VII-secretion-target	gnl|CDD|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	1.501e-13
NZ_CP045178.1|WP_077970078.1|2857990_2860705_-|protein-kinase/lanthionine-synthetase-C-family-protein	gnl|CDD|271199	cd04791, LanC_SerThrkinase, Lanthionine synthetase C-like domain associated with serine/threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown.	2.76842e-73
NZ_CP045178.1|WP_077969550.1|2953940_2954603_-|hypothetical-protein	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.11688e-06

Protein sequences

>NZ_CP045178.1|WP_107502927.1|2864756_2865521_-|type-VII-secretion-system-associated-protein
MANPPETNGSEQEPGNRVPGAPDAGDASGTGADAAGADAATGTDGTDEEAPVLVRPGEPGFPPPPEGMVEAAKLAPDHWLNVVDQAWRSPEGEEPPSWAMLGRWRSDETGEIVEWEWNPDYRPSPERMGWNDPVGPADAACQLAATGYGPEDDVARALVGAEIAVCLDDEGKPSVTETPDGVSAVAVFANAPDLDADQLPPHEMMRVRDLLEKLRAEEEVLFLSSSAPVALLIEKSALRRFQNDGSDNGRVQGP
>NZ_CP045178.1|WP_077970080.1|2863668_2864604_-|RICIN-domain-containing-protein
MSEAQSEDEKRRERARRVDALSDAARQPGEGPRFGTRVAGAIAVLALAAGATLGVGAWHSYQNESDQKKAEAAKLQAKEVAAHQDISPSPSPSESKKEKKKQEIATQPQSVGGGPAAEPQKESEKPADGATKKPKETVEKPEAKVKLTPKANMAAEGFSRVVLANKSTRMCADLPGADGHPEGDGMVDQYPCDASDNDNQLWNVTVSHAGVGPGGTDLVLIANVKDGLCLDLPYYGAQDVGARVQEHACTSSMQDNQQWRFEDMPDGSKRIHNYASKGLCLKVAYDGLDRVNTPLTIGDCQAPSAEWFLRR
>NZ_CP045178.1|WP_077970087.1|2861631_2863485_+|ABC-transporter-ATP-binding-protein
MRYVEVTGRREAAGRSIRLRDMARRLPQLVRRSLALAWRVDRHATVGLLLCQAASGAMQALGLVAISGTLTALLNSGDVYQRLLQAWPSVVLLAGAVGVRALLGITVNWLSSRLGPLMSREAEQMLLTGCAEVELCAYDEPDFNRDREAADRGAQVTGELIDQGQDLIASGASFVAGAVVLAGVHWVLLPLLVVASFPQALAQVSAARVRYLANLRSNGDNRMLTVLRWHIFTKDAADQIRAGTMAGFLAGRYRQTVVRINKEDRAAADKGARMSLVGSLCGGLGSAGVWGAVVWLLATGRISVGHAGTAVFALQTVGQSVRALVSVGARAVRTGLYMDDWSGFLEKAGGHRMERGTYRPEPPKEIEIKALSHRYSGQDTDTLSDISLTLRRGEVTALVGYNGSGKSTLSKLVGGLYLPTDGQVLWDSTPTGDIDPQALWQQVALVPQDYAHWPMTVRENVTQGQPTAGGDKAVREACAAAGADEVVDRLGSGLDTLLAREWLNGEELSGGQWQRIALARAFFREAGLLVLDEPTANLDPRAEFRIFQRLRELARDRVVLLVTHRITNVAVADRIVVLDEGRIVQEGTYRELAEREGLFRQLLSYQMTSEATARGEE
>NZ_CP045178.1|WP_077970078.1|2857990_2860705_-|protein-kinase/lanthionine-synthetase-C-family-protein
MTPHALEAPLEGLLKKALLITGTDERWSAQTDEMWCRVGSRLGARREQGWKLHVSATVASAPEVLTRALDVLLRADSAFKFARSLDQVSALNTRGTPRGSSGKFLTVYPRSDSEATRLAQELHRATEGLTGPRILSDQFYAPHSLVHYRYGSFVGRRRLSEDGLLVWFIEDPDGNPVEDKRTGQYLAPTWAVCPFPSPAPSRAPAEPRPATSAPPAGPVLLGGRFEVREAIRQTNKGGVYRGTDVRTGGRVVIKEARPHVEADVEGRDVRDWLRAEAEALEGLRGLELAPAPVAVFEHGEHLFLAQEEVPGVSLSTWVAEHFREAGADQYGADALQVVTRLVELVSQAHARGYVLRDLTPGNVMVRPDGGLRLIDLELAVLGTASCPPTRVGTPGYSAPERLSDAPVSQTADYYSLGATACLVLAGKIPTLLADEPATRTTEERLATWLTTCAGRLRLSDEIVAMLLGLMRDEPAERWNVSRAREALRTTTATAAKPGGGDGVVRPGVNDSPRGPVAGSADDPVAGITDHLISSMTPTDDQRLWPVSTKTGETDPCTVQQGAAGVLAVLTRYFTLTGDPRLPEVISTAGHWIADRSDAASARPGLHFGSRGIAWALHDAGRAVDDRGLTDHAVTLALAPLRPTPSHDITHGTAGSGTAALHMWHHTGDRRFAELAGAAADRLVAAADRGPDGVSWAAPAEAEIASAGKRYLGFAHGSAGIGSFLLAAAAVSGRRAHRELAVRVGEGLLAHAVLTGETAHWPAQATDAPTAPYWCHGAAGIGTYLVQLWQTTGDDRFGDLARRGAHAVAEQASRATLAQCHGLAGNGDFLLDMAAATGDPVYRAMAEELADLILTERVHRQGHTVFPTEYGDVSTSWSDGSAGILAFLLRLRHPSLRHWMVQPPV
>NZ_CP045178.1|WP_143621365.1|2856490_2857630_+|hypothetical-protein
MNTPQDSANNPPVSNGGIPEAGGMYFVADIVTTPSYKISWDNSWLPRDNPDTKGWATPVKLKSPVFYHGSFTYDQDNTLAYHVVPWIHTEWPDGSGFRNPDSWERGWSGTTWEKFNDPDGIPYWSFYYSKPLRRLYAGRKNEPKVDIYDRVGSDHRRTGTLPALGCHFNGNDGIWDLVVDSEETIYAIIGNEVHKGSPTKNGGFEEEVYYSTPKASRLALARTSSKTYVIASSVYAGEAALYRISPVLKEGRADIINVPKSWNVTTPPVIVETRRKTFWVSTGGTYAIWGDVDRPDDQAQWNYFDEKHHAGTDAQYSAPGVKDGKVYWLSTWGGKPWVYCLDPLNPPHGNIPSSQTAMRPEQFDWNVYNRSVNMAWVDC
>NZ_CP045178.1|WP_077970076.1|2855559_2856423_+|hypothetical-protein
MTTTPFTAPAFAGWREVTPGDRRAVWSVLHFDWPTVWELYLAEGKDHGTWITENWTDTDGLSHSVTHIKVLEKWYGLSDYFTNEVGPVTAFSGPGIATFDDSAEPPTPTPFKFDIYFLSQLTDPAKTDVYRLQQPGFAKTPKITSTALRTLFPWVSKPPFSTPFTITSVANLYTRTADSKWVAVIGTNDKNETQYVVCQTGSKQVSDPKRIDADGLDGRAAFGVPTITATTHLNDSPLYVLGSHPGTSAPDTLTPFTYSPQLVKGPLTTASTLTKSGAAQTYPEPQS
>NZ_CP045178.1|WP_077970075.1|2854363_2855563_+|hypothetical-protein
MSDFTLGYITDPSPLQADANGKITIKVQPTAGNPSAHVGDDSLYGFHITFPVGTGEGDLTTPENVHGIGLKASDPKATAAVGLDKDTHTATVSVSSPFPKKGLTISIKDIRVGSPGEFKLTTSYTRPHETDRRVLDTPRPFAKSSGAFYFSNLKADQPQVESGKEGRLTWNASDHMDSYTVDWAGTSSAGGSRTLDAKAVAWTTPKLDDPATTFCLTATATLHGAVVRHSLWVTVFGRRGMARTGHLQALGTVRITDPRPQYVFDDVALTTHQVNRASAGVFEDQTLPAEGKPLSEIFPLSCLTPSDGALLIRVTGDPFETPLQLTARYPSESADSGLTKEWGITAGTSLTLPLPTGTALEFTEPAYMGGERRLTVHWAAQGGHQPLALAHTRTTGRTS
>NZ_CP045178.1|WP_077970073.1|2853429_2854260_+|hypothetical-protein
MSDTPDAFTLSNLRITPEKITHGRPAHLTWDTTAGSAQYTVRYAGPKTPLVTINPTDKGHVPPTAKEWDSPPLDDWVVVFTLTAQVQDDYQTVAATVFVDRGDAEFGDLDAKGIVRLLAAPQYLFDDVVLVDRDGTHMAVSGTFEGQQISQPKSLHDIFGDGGRRTYTAPSDGILTLRTNTPEGSSGTENEMTMLVTVGPPTPPIPAALAQRTGAPPPFNDRVKEWTITAHDSLTLPIAAGTTLDLDEPSYDGGQRGLTVHWSAFGGPNPLRHDAG
>NZ_CP045178.1|WP_077970071.1|2849707_2853217_+|hypothetical-protein
MTTSSVQPLLVPVRLDALPVTQATRTSAVFNRWHPDFFKLTESYKDPTEMTEEDFSEEEDTDKNGVYLQWRLPEALRHGPQRADGRVGLPRTPNRWLVVRYSGGGGKAGQAAWVVESDFTSENAADGTNKFVREDKGGSLEKVWIGRAVCLDDETWSETRADDPLFLDAFGTGLAAFSMYQPYNENMLSFHDPLDDLTTGEVHLSYLLLGWYSRADGDPLTVPGGTTLADLLKGLRWENDALRAPARTLCVGTALDVLWQPKTADSATDHRPDPDRIDVVVGQSVQDAQLALPDRLGGLSPQDREALGAFRHDAWDHYHRPGGAPRIEEATHHQGFASSHGGVSWDRRPLQRGSGAAEAETVVDAGVLDTLDQAQRDLEEARRGKRDALRNLFELDWATRGDGSKQQVQQGWEDKLRQATALELDALKRLQPPPGAIPFPEQEFSEITDPTILLTGTKVSEPLTAGEALTCRVPGQTLTSLLGRTPPSELPGAKFLSVLPDADARAAGLRALAEFWLLDTAARTPGDQHSELETYLEGLTAADRKKFPHTRQWELPWLPLFLVWTLQCHPIAYQDKQEQPYWEFNGQDYTWSGRGGEGMKRTTLRGRSLLTPLPQFIDRNLALRNAERATTDEDSRAWRELADLLGKKDYMSQSLAGVNDWFQQLAPVPHIPKEELKAHTGIRVPVENERAPQFLPVRAGQANFYELSLVDGFGQSVPIVTPGDLGNYRHRPLICSPTTRPGNTLLDTEDRHERATVFQMPPRVLHRTRLRFDAMHPATGSRSTRRSAQPTSVCGWLQVNHLDRTLILYAPDGQAAGQIQVNRRATGTESDSGTGTGTGSDRLAWRALPPRPPTESWLQARTALSLSEDLARLVDHLLDQDRPFPIAEFEALLDLIDTSLDNEARREHEQDNFAYLAGPPLAVVRAGLRLDMDGLPPGGNTGSWDPEPGRQLAGYVWGLSLGQDTDPDDGLVGYFNSECVDRLWSPHSVDDYPYGEASYLQKAAPGHEDPDLQVKATPVEDPPSPANTHYVTLLMNPWKSVQAISGILPANRLKLPEDQVRPAMDQVKVPFALGPVLAHLTEAVFSGTTATSKPVKTVSMPRPAIWTGTWQWTQPHPTHPEDGGEPWTPWDLHEIVPAPATAQFTPERPVARAGFLCNTHNYLPAPPTE
>NZ_CP045178.1|WP_077970069.1|2847278_2849708_+|hypothetical-protein
MTTQVFTEVPQPLQVELADALVPSVEAGEYYTELTHVWAKGDDEHPLTDAPVKRAFSVMSPQMSLPHGTVHAVIPADSTSGFFQTVLPHVTLERAVLPWERLPAGGSALSGEMALPPSWLAVLLFAEGELPGDPGAVGERQARTAKEFKDKAVQEAVVWPDITVQAPDSEPCFSIDVPADVFARIAPREEELPYVAHTRTVREKKTESAWFPPAEDGEDLTQGQFSVVLSNRMPRAAGRYVAHLVSLEGWSERLTEAHVPQRGTMLRLISLHSWVFDSHDTKGKDFERLATALARPEHVPGDAVDPHRLDLALRPTPGNSTSAATERLRRGYVPVEYRVHSGERTLAWYRGPLTPMTAQKLPAPGEVGQVQVARYRSAEECHTYVQGQGVFDIGYAAAWALGRALVLANGDLSKRLVKARSLGWETLHTVTAYLQRHPDADEAEIRAHLDAALPGPTLFARRLREGLLDRLTTALASPGQAPTDREPVAPDPPADVPLSWRERTVRAWDHPDIDVKAMVRARMARHLTARGAVDHALLYPPPPADDRDPLVAPGSGLDALTLLCSAPFSYLVPDPRMLLGPQPREPAGATSGEGLRLFYLDSGWLACLQDGAVSVGIGTTLDASLTDELRKTLLAHPGTPVTGLLMRSRLVEACPDIVIEATTGPAEKPVRLVALRREMAGDLLMMLFAGVPDTISLQEPDHGIHFGAKGDWEELSWSLRALKGDGSQPVGRPLTASVALDPATQLRRDGAGDVLHLCGGTPGLVAALSTELIKQKQLDKGLLSPGQLGLQLTRSPLKLDLTRATEGRS
>NZ_CP045178.1|WP_077969551.1|2949717_2953812_-|type-VII-secretion-protein-EccCa
MSRIPFHRPVRITPPAMPEGKTTLAALPQKPQPPGAAQWVMLLLPLLSSFSMAAYMISNGRPWMILMGIAFVVLSVGVTIGVRMQLRSSRRRNQERQREKYLEYLGDLRKQSLRTAAEQRLAGVWQYPHPDRLWAIADRRRRVWERRPGDADFLRLRVGTGTTPLAHRLSLPTQNDPTVEVDPHARHAAAEMVQEVNTVAGQPAWLDLGSAGVVSLLGPRERTRALAQTMLMQLAVLHAPDDVRLAVVSGGSPVWEWTKWLPHTQDPGSEASLRDQEVVPLVAADISSLQDHLLETLERATAAQAERSARFLPSGSETPRQRLVVVLDDFDPAAAWARSPLVSGLLAQAGPDSALHVICLVAEERDEPGRVDARARVDEEGGVSLEGRTPRLYSAVEGAVADEVHTAVRESAARALAPLRLSGEREQVLAEAVSLSDMLGIPDLTTFDPSRNRRTPEAPDLLRVPIGVDGTGAPLELDLKESAQGGIGPHGLVVGATGSGKSELLRTLVTGLSTVHSPDHLAFVLVDFKGGATFAGVTELPHVSGLITNLADDLALVDRMRAALQGEQQRRQRMLRDAGDVDSIREYQLKQAAGGTDIEGNPLEPLPYLMIIVDEFGELLSQRSDFIELFVQIGRVGRSLGMHLLLATQRLEEGRLRGLESHLSYRICLRTFSAAESRAVIGTSDAYTLPAIPGSAYLKVDESVYERFRVAHVSAPYQTLRPADEEEERLEPVAYAVRGDLPPLPDDAATEARTWEWSDSGETELQIAARHLINEDIPGHQVWLPPLPEQFSLAPLLGELVPDADRGLTSTHWPFPGSLKFPVGVIDLPERQEQQPLVLDAAGRQGHVALVGAPQSGKSTFLRTALLSAMLTHTPEEMQFYAVDMSGGALHQLESAPHVVGVAGRRDGARIRRVLAEVSRVIGTRERMFRELRLQSADDLRTRRAAGNLPAGVNAADIVLVVDNWAALNAFDDTVAATVTEIATRGLGVGVHLWLTANRWQEVRANLRDAIPGRLELRLNDPSDSEVSRIAARQLGEAAPGRGISGTGVVHHIALPRLDDEDALEGLSEAQERLISRIVESWKRPSPQALRVLPELVTSVDLAAAVSARPEEGRRWEGNGPALEKGEVPIGLREVDLRPVGLDMTRGQSHFVVFGDSGSGKTAFLRGWMRGIAAQHSAREVRFMVADYRRGLLDAVPEEYLGAQGGDADLVGRQAAALIDTLRKRMPPAGITARQLKERDWWEGPELYVIADDYDLVSGGAMSRGPLAGLADFITQAGEIGFHLVLARRVGGASRSLMSDPLLSRLRELDTDGLLLSGDRREGALLGDQRAQQRPPGRGLLIRRRQQPSVVQLAWEEERDVTRD
>NZ_CP045178.1|WP_077969550.1|2953940_2954603_-|hypothetical-protein
MSDDWVSYDSVKIEVDPAALKEMTTQLKQSITAVSGHLNRINKTLGGLKLNWAGKTSEEYDHMTSEWTRVINMAFGTEKEPEKGALNAVGHGVEQAASNFANTEQGIAKGFDDLIAALGPQLDDAEPAAPKDSLDRVTTAISANYASDYSEGDKDNEEKHDRAVKNGFGHDQETGPDIDAYMENYGGVNTPDDHAAAVKDQKDKDDDVIADYSKSDYDRD
>NZ_CP045178.1|WP_077969549.1|2954808_2955447_+|hypothetical-protein
MGDTDSQAVDSKYDESPLQPPSDEESDSSDSDDVDIPDEVEDLSADVPNVGVMWESPPSWNLDPSGGDSSGSGDQSDDIPDARRFKVDAVDVRAAEETMLSESRTAVSGYTQLQQKVATEKGTVFGQGLKYWDAPGEGYSYGVPAPDPELMGSMFAGDDFAAVINPIQEQVLSEIGGLLETTGEFIAMINAAGQAYSQADRDSKFPEPPADI
>NZ_CP045178.1|WP_077969548.1|2955608_2956421_-|hypothetical-protein
MGLEVPILSIQPTGCESARPPSEGGFLAMTKRDDLENTMEEFGDKLDSFDGEQSDYDKAEADYNAADAEYNSTVDDIETKAKNDPEYTQSEYDADTELLNAADEKHQGAWDEYKAASDDYKADYDKYKSDYATYANAAHELLRIDMAALAQAIPVVALETVMVSVEMAKIQNTLNSVGDAWQGPAFQSYEAVQQWFQRTQKSLEELLMEILRRMRASQANYKDAEEKNFQNVTPDGGDPLPGDDNESMRRTAGNAEWAIRIAGAGQGGSS
>NZ_CP045178.1|WP_077969567.1|2956497_2959362_-|AAA-family-ATPase
MKGGKQQRVAPGSWGAHRTIGAALRAAGPGTTITIRPGTYTESLVLDKDVTLVADKGAGSVKVVAARGPALTAHGGSPEVRGLTFEASSPREPAVLLRSGEPTLRDCEIIGGRIEVSESAAPTLTGCTVSGAAPAAVRLAGTSRTTMEQCAVNGCQGDGIVAEDEARLDATETIIDRAGGRGLYLGGASQVTLTRCEVKHSTGAGLFADVRSSAVLRECRVHETGAQGIRLAGTAGRPASRPGAGQRGPQEDRAGKRDGASGSASADGLADADTYGVRLRSCEIFRTKGAGVLAEGESAALLDECHLHHTGGAALIATGSSSFRMRKVRAVDTTDSALVLSGKATATADETTFARTGANGVYAVGDAELTFTGCTVKDTAYTAVHLGGGARGRLSGCTVSSTPEYGIRATERAELIAHDCETRETELVGVCVDGGDAALRECRVSGGRLGIRLRTSHRPLLVDCVISDVVGSGIEIGPGTGALLENVTVERSGSSGLVLDTDSTAVVDGGAIRESGGSGIVVRAGARPRIRSVAVERAAKNGLFIEEGGEGLYEDCDFTDSRFPAVYAGAKSRPELRRCAVSGCEQDLLRDDEADVRAEDCTADGVEDAVLPTLDPADTSDGTPRRMTAVAGGPADGGRTTRRGAHSKAGKAGKAKGKKEEEGEERSAQERLAELRTELDRLVGLDSVKRDVMTMTKLMQMVKVRQDAGLSPPPLSRHLVFAGNPGTGKTTVARLYGGFLAALGLLERGHLVEADRGDLVGEYVGHTAPKTTAMFRRALGGVLFIDEAYSLVPHGIGNDFGTEAIATLVKLMEDHRDEVVVIVAGYPADMNRFLASNAGLASRFSRTLTFDDYSSPDLVRIVEHQAGSHQYTCPPETLAALGEYFERLPRGEGFGNGRSARQLFQTMTERHAQRLAEIDLSVLDLTAADAGVLTTLLPEDLPVLPQDLAQGGAR
>NZ_CP045178.1|WP_077969547.1|2959633_2960980_-|hypothetical-protein
MPDERCRVTVIGERKRVDLALPVRAPIAEYAPRLATLCGEEESEAMPPVWSLAIAGSLPFPSGDSLEASGVVDGAVLYLRDARADEDLDLSITDLDDQVSAANEDIQRWNARNRALSVIIAGLFGSTLAAGTLGTRQQAGPAAVMFFLLGLVSALTAWYATRKSWPVPAGVRQVMALAAVPLVTAAGIGLPLHGPVATPVVVSLSVLVGALAALLAVPAVSTVVVMVLSVLAAVLAIPLAILGADRYAMAGTVAAVILLLFRVLPRAASQIAVLAPAPQPDRPMRESEEVAAAVRRGNRLLAFLTILFAVVLGCCFMLLCMSEDAYAFGLLGCASVAVLLDAGSSRLLPAVAPQLAVGTAGLVALLARLPEVLFDRPVPGALVAFGVGIVLTACGLGMAFRAAVRTVDLTERPKWLTGLASLLAMLCVPLAVGVFGVFEGLMNLGGSL
>NZ_CP045178.1|WP_077969546.1|2961108_2961423_-|hypothetical-protein
MSNIDGTTIYVGEGLGAAGKWLNGRAAQISDELAALKGKLAPLAEAWSQSQAATYYQDMQNEWDISAEGLFGPEGVLGRIAHAMDVNWNNYSEAEWSNVSTWKH
>NZ_CP045178.1|WP_077969545.1|2961513_2961897_-|WXG100-family-type-VII-secretion-target
MAEQPPTTSVGGVQYRVTPEYLANASADAERTASEIAAELQQIKTYVLSLEADWQGIAHNQFQTLMQEYDNYAQMLHRALHGISQGLKGSYINYSESESQNLSNLTALGADIPSPGGGGSPTPTNFS
>NZ_CP045178.1|WP_143621349.1|2962570_2962840_+|hypothetical-protein
MVILTGENQKTDKGAERITIRQKSAPVTTAPAVLAAAAAANTRSHTYEPSQRAPYHDDHGCGLRASAATKDIARPHPPGVGPVDGQVNI
>NZ_CP045178.1|WP_077969566.1|2963707_2963881_+|CsbD-family-protein
MAADEKAKAKGEQVKGKTEETAGRAVGNERLEAKGQADKSKGDARQAKEKTKDAFKP

Crispr_ID: NZ_CP045178_7

• CRISPR_ID: NZ_CP045178_7
• CRISPR_location: 3430065-3430157
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_7

Consensus_repeat	Method
GCCGACGCGGTGGCCGCCCCCGCCGTGGCGGCC	CRISPRCasFinder

spacers of NZ_CP045178_7

>7.1|3430098|27|NZ_CP045178|CRISPRCasFinder
CCCGCCGTGGCGGCCGACGCGGTGGCC

CRISPR arrays and Neighbor proteins around NZ_CP045178_7

CRISPR arrays

The CRISPR arrays of NZ_CP045178_7

>merge|NZ_CP045178|7|3430065-3430157|CRISPRCasFinder
GCGGCCGCCGTGTCGGCCGACGCGGTGGCCGCCCCCGCCGTGGCGGCCGACGCGGTGGCCGTCCTCGCCCTGGCAGCCGACGCGGTGGCCGCC

>NZ_CP045178|7|5|3430065-3430157|CRISPRCasFinder
GCGGCCGCCGTGTCGGCCGACGCGGTGGCCGCC	CCCGCCGTGGCGGCCGACGCGGTGGCC
GTCCTCGCCCTGGCAGCCGACGCGGTGGCCGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077970143.1|3434957_3435653_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP045178.1|WP_077970130.1|3425304_3425730_-|glyoxalase	unknown	unknown	gnl|CDD|319909
NZ_CP045178.1|WP_077970128.1|3424677_3425277_+|Uma2-family-endonuclease	unknown	unknown	gnl|CDD|99749
NZ_CP045178.1|WP_077970151.1|3441017_3441911_-|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	unknown	unknown	gnl|CDD|235110
NZ_CP045178.1|WP_077970138.1|3430404_3431376_-|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl|CDD|187558
NZ_CP045178.1|WP_077970148.1|3439035_3440850_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|223562
NZ_CP045178.1|WP_152330765.1|3422791_3423715_+|acyl-CoA-desaturase	unknown	unknown	gnl|CDD|224316
NZ_CP045178.1|WP_077970136.1|3428322_3428775_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|223532
NZ_CP045178.1|WP_077970135.1|3427283_3428060_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP045178.1|WP_107502935.1|3434464_3434761_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970132.1|3425759_3426584_-|trans-aconitate-2-methyltransferase	unknown	unknown	gnl|CDD|184509
NZ_CP045178.1|WP_077970152.1|3445769_3446714_-|TatD-family-deoxyribonuclease	unknown	unknown	gnl|CDD|238635
NZ_CP045178.1|WP_077970282.1|3435916_3437881_-|PQQ-binding-like-beta-propeller-repeat-protein	unknown	unknown	gnl|CDD|370676
NZ_CP045178.1|WP_077970139.1|3431372_3432452_-|galactose-1-phosphate-uridylyltransferase	unknown	unknown	gnl|CDD|238341
NZ_CP045178.1|WP_077970134.1|3426827_3427325_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP045178.1|WP_077970140.1|3432699_3434367_+|sodium/solute-symporter	unknown	unknown	gnl|CDD|271372
NZ_CP045178.1|WP_077970283.1|3443454_3445014_-|DUF348-domain-containing-protein	unknown	unknown	gnl|CDD|226111
NZ_CP045178.1|WP_077970122.1|3419591_3422345_-|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl|CDD|366019
NZ_CP045178.1|WP_077970120.1|3418799_3419408_+|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl|CDD|235457
NZ_CP045178.1|WP_077970126.1|3423778_3424456_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077970143.1|3434957_3435653_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.34279e-32
NZ_CP045178.1|WP_077970130.1|3425304_3425730_-|glyoxalase	gnl|CDD|319909	cd07245, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	1.25493e-30
NZ_CP045178.1|WP_077970128.1|3424677_3425277_+|Uma2-family-endonuclease	gnl|CDD|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	1.66438e-22
NZ_CP045178.1|WP_077970151.1|3441017_3441911_-|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase	gnl|CDD|235110	PRK03188, PRK03188, 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional.	4.46937e-152
NZ_CP045178.1|WP_077970138.1|3430404_3431376_-|UDP-glucose-4-epimerase-GalE	gnl|CDD|187558	cd05247, UDP_G4E_1_SDR_e, UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.53432e-169
NZ_CP045178.1|WP_077970148.1|3439035_3440850_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein	gnl|CDD|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	6.3627e-162
NZ_CP045178.1|WP_152330765.1|3422791_3423715_+|acyl-CoA-desaturase	gnl|CDD|224316	COG1398, OLE1, Fatty-acid desaturase [Lipid metabolism].	3.14043e-68
NZ_CP045178.1|WP_077970136.1|3428322_3428775_+|GNAT-family-N-acetyltransferase	gnl|CDD|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	4.25571e-08
NZ_CP045178.1|WP_077970135.1|3427283_3428060_-|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.7715e-41
NZ_CP045178.1|WP_077970132.1|3425759_3426584_-|trans-aconitate-2-methyltransferase	gnl|CDD|184509	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional.	9.08319e-115
NZ_CP045178.1|WP_077970152.1|3445769_3446714_-|TatD-family-deoxyribonuclease	gnl|CDD|238635	cd01310, TatD_DNAse, TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.	7.27257e-96
NZ_CP045178.1|WP_077970282.1|3435916_3437881_-|PQQ-binding-like-beta-propeller-repeat-protein	gnl|CDD|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	8.60688e-14
NZ_CP045178.1|WP_077970139.1|3431372_3432452_-|galactose-1-phosphate-uridylyltransferase	gnl|CDD|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	1.59316e-116
NZ_CP045178.1|WP_077970134.1|3426827_3427325_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.53104e-17
NZ_CP045178.1|WP_077970140.1|3432699_3434367_+|sodium/solute-symporter	gnl|CDD|271372	cd11478, SLC5sbd_u2, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
NZ_CP045178.1|WP_077970283.1|3443454_3445014_-|DUF348-domain-containing-protein	gnl|CDD|226111	COG3583, COG3583, Uncharacterized protein conserved in bacteria [Function unknown].	4.11789e-54
NZ_CP045178.1|WP_077970122.1|3419591_3422345_-|phosphoenolpyruvate-carboxylase	gnl|CDD|366019	pfam00311, PEPcase, Phosphoenolpyruvate carboxylase.	0
NZ_CP045178.1|WP_077970120.1|3418799_3419408_+|aminoacyl-tRNA-hydrolase	gnl|CDD|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	5.68549e-91
NZ_CP045178.1|WP_077970126.1|3423778_3424456_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.5449e-18

Protein sequences

>NZ_CP045178.1|WP_077970136.1|3428322_3428775_+|GNAT-family-N-acetyltransferase
MVSHMFRMETGVDKERRDLLRSQLRAANIEASPALRSLLGSTAESEVPLHLWLLDEEGALAGGLVAHAWAHWLHVNYLWVDGRHRGLRLGARLLAEAERRAREELGCGSARVETWDFQAPDFYRKQGYSVVCEIPGYPPGVTEFTLTKQL
>NZ_CP045178.1|WP_077970135.1|3427283_3428060_-|response-regulator-transcription-factor
MVRIRVLVVDDHRIFAESLAAALAAEPDVDVSAAGSGPAALRSMERASAEGRRFDVLLIDADLGGAAAMMSGGRVPTAVQEGTEGGLVDGISLVAGVRTGQPAVRTVVLAEKDDPRRAALALQAGASGWVAKDCSLSRLLTVIRGVLRDETHLPPALLTGVLRELTAARKHRTESERLVESLTPREREVLRCMVAGLGRKAVAERLFLSPHTVRTHMQNVLGKLGVHSTLAAVALARRAGVGPVDLAGNVVERGGQLA
>NZ_CP045178.1|WP_077970134.1|3426827_3427325_+|MarR-family-transcriptional-regulator
MEDEVDRLVAAWRRERPDLDVEPLEVLSRVSRLARHLDRARRLAFAEHHLEPWEFDVLTALRRTGSPYQLSPGQLLTQTLVTSGTMTNRIDRLTKKGLVERLPDPSDRRGVLVRLTVEGQERADSALAGLLDQERALLSELSRAQRGELAALLRQLTAPFDNIPG
>NZ_CP045178.1|WP_077970132.1|3425759_3426584_-|trans-aconitate-2-methyltransferase
MATAAWDPHQYLRHRDHRARPFTDLIARVPVLPTAQDGHPPHIADLGCGPGNATALLTERWPTAHVTGFDNSPDMLERARRDHSGPTPGGGSVDFAHADVTTWIPERPYELIVSNATLQWVKGHPDSFAAWTGALTPGSTFAFQVPGNFDAPSHVLMRDIAESPRWRSRLGGLLRHGDAVLEPAAYLAGLTALGLDTDVWETTYLHLLHGPDPVLDWVKGTGLRPVLGALADDPEALEAFTTEYRDALRAAYPATEHGTVLPFRRVFAVATRPR
>NZ_CP045178.1|WP_077970130.1|3425304_3425730_-|glyoxalase
MLAAVDHIQLAAPPGSEETLREFYADTLGMTEIPKPPALAGRGGAWFRAGSVVLHLGIEQGFRPARKAHPGLRVTGIDAFAARLAARGASVTWDEDLPGYRRFYSDDPHGNRLEFLEPTSADAPEDLPEDPPEGLADPKAP
>NZ_CP045178.1|WP_077970128.1|3424677_3425277_+|Uma2-family-endonuclease
MTAKPAQPQYSWPVPPQGGFTVDDLSTLPDLPPHTELLDGSLVFVSPQRDFHSVVIDLLVAGLRVAVPARYRIRREMTVVLDRHNGPEPDVCVVRAEAKVSAKQTRYVADDVLLAIEVVSPDSEGRDRDAKPRKYAAAGIVHFWLVEMAEGNGHPVVHVYELDPLTRSYALTGIHHERLKLAAPFTIDLDISSEVLDAL
>NZ_CP045178.1|WP_077970126.1|3423778_3424456_+|TetR/AcrR-family-transcriptional-regulator
MMGAVATDSSSGTSGEKPRRARRTRMTGAQRREQLLDIGRTLFAAKGFEGTSVEEIAAKAGVSKPVVYEHFGGKEGLYAVVVDREMRQLLDMVTGALTAGHPRELLEQAAFALLDYIETYTDGFRILVRDSPVAQSTGTFASLISDIATQVEDILGLEFKSRGFDAKLAPLYAQALVGMVALTGQWWLDARKPKKAEVAAHLVNLAWHGLDGLEPRPRLIGHRKS
>NZ_CP045178.1|WP_152330765.1|3422791_3423715_+|acyl-CoA-desaturase
MTASSDVSDVIEDVPRPAGGAGARAATLGGDRKGSVEQVALLLFILVPFAALVVAVPLAWGRGLSWLDVGLMVFFYFLGCHGITIGFHRYFTHGAFKAKRPLRIALAVAGSMAVEGPVVRWVADHRKHHKFSDAEGDPHSPWRYGESLSALTKGLWWAHIGWMFDEERTPQEKYAPDLVKDPAIRAVSRQFVLWTVVSLGLPPLIGGLATMSWWGAFTGFFWGSLVRVALLHHVTWSINSICHAVGKRPFNARDRSGNVWWLAVLSCGESWHNLHHADPTSARHGVERGQIDSSARIIRWCEKLGWA
>NZ_CP045178.1|WP_077970122.1|3419591_3422345_-|phosphoenolpyruvate-carboxylase
MSSADDHTPGSHEAAATAGAELRADIRRLGDLLGETLVRQEGPELLDLVERVRALTRSDGEAAAELLGATELETAAKLVRAFSTYFHLANVTEQVHRGRDLRDRRAADGSLLARTADRLKDADPDHLKNTVAHLNVRPVFTAHPTEAARRSVLNKLRRIAELLETPVIEADRRRHDTRLAESIDLVWQTDELRVVRPEPTDEARNAIYYLDELHAGAVGDVLEDLTAELERVGVTLPEGTRPLTFGTWIGGDRDGNPNVTPEVTWDVLILQHEHGINDALDLVDYLRGLLSNSIRYTGATEELHTSLAADLERLPEISPRYKRLNAEEPYRLKATCIRQKLENTKTRLAKGTPHAAGRDYLGTGELLSDLVLIQTSLRAHRGELFADGRMNRTIRTLAAFGLQLATMDVREHADAHHHALGQLFDRLGEESWRYADMPREYRAKLLAKELRSRRPLGPSPAPLDAAGHKTLGVFHTVRKALEVFGPEVIESYIISMCQGADDVFAAAVLAREAGLIDLHSGWARIGIVPLLETTDELRASDVILDEMLADPSYRRLVSLRGDVQEVMLGYSDSSKFGGITTSQWEIHRAQRRLRDVAHRYGVRLRLFHGRGGTVGRGGGPSHDAILAQPWGTLEGEIKVTEQGEVISDKYLVPSLARENLELTVAATLQASALHTAPRQSDEALARWDTAMDLVSDAAHGAYRALVEDPDLPAYFLTSTPIDQLADLHLGSRPSRRPDSGAGLDGLRAIPWVFGWTQSRQIVPGWYGVGSGLKALREAGPDGVLDEMHEHWHFFRNFLSNVEMTLAKTDLRIARHYVDTLVPDELKHVFDDIVAEHELTVSEVLRITGGEHLLDSNPLLQQTFAIRDAYLDPISYLQVSLLARQRAEAENDETPDPLLGRALLLTVNGVAAGLRNTG
>NZ_CP045178.1|WP_077970120.1|3418799_3419408_+|aminoacyl-tRNA-hydrolase
MTTPSGSDTGGPWLVVGLGNPGSEYADNRHNVGFMVADLLAARMGGKFKRSGKAQAQVVEGRLGVPGPGSRRVIVAKPQSYMNLSGGPVTALRDFYKVETARIVAVHDELDVDYGVLRLKLAGGDNGHNGLKSMTKSMGPEYHRVRFGIGRPPGRMQVADFVLRDFSSVERKELDFFVDRAADAVEALITEGLERAQSSFNS
>NZ_CP045178.1|WP_077970138.1|3430404_3431376_-|UDP-glucose-4-epimerase-GalE
MTAKYLVTGGAGYVGSVVAARLLEAGHHVTVLDDLSTGFREGVPAGAEFIEGRVQDSANWLDGSFDAVLHFAAFSQVGESVARPEKYWANNVGGTMALLTAMREAGVRKLVFSSTAATYGEPVNTPITETDPTAPTSPYGASKLAVDHMISGESAAHGLTAVSLRYFNVAGAYGAQGERHAPESHLIPLVLQVAQGRRDAISVYGDDYPTPDGTCVRDYIHVADLAEAHLLALTAGAPGRHTICNLGNGNGFSVREVIEMVRKVTGHAIPEVPAARRPGDPAVLVASAETARTSLGWQPTRADLAGIVSDAWDFARRIAEEDK
>NZ_CP045178.1|WP_077970139.1|3431372_3432452_-|galactose-1-phosphate-uridylyltransferase
MKKTSTRLADGRELVYYDRRDDAVREAADERPLDPVATASEIRHDPLLGDSVAIASHRQGRTYHPPADQCPLCPTREGRLSEIPEDDYDVVVFENRFPSLAGDSGRCEVVCFTSDHQASFSSLTQDHARLVLEAWADRTAELSKLPSVTQVFPFENRGPEIGVTLGHPHGQIYAYPFTTPRTALMLRSLAAHKAATGGRNLFDDVVAEERASGKRIVLEGEHWTAFVPYAAHWPYEVHLYPKRRVPDLPALGEEARTEFPQIYLELLRRFDRIFGEGQPQTPYISAWHQAPFTGADAFTADPAHPVDRDDFALHLELFTIRRTTGKLKFLAGSESGMNVFINDVPPETAAQRLREVASS
>NZ_CP045178.1|WP_077970140.1|3432699_3434367_+|sodium/solute-symporter
MHLAEGLRLPTNGLDYTILAIYFVVVLGIGFAARRSVKTSLDFFLSGRSLPAWVTGLAFVAANLGATEILGMAANGAQYGVYTVHWYWIGAIPAMVFLGLVMMPFYYNSKVRSVPEFLLHRFGPSSHFLSSVIFAVSSVLIAGVNLYAMAIVLEALLGWPEWVAIVVAGVFVLIYITIGGLSSAIYNEVLQFFVILAALIPLTIVGLKRVGGWDGISDKLTSSHGGQFMTAWEGTGVGSSNPLGANWLTIVLGLGFVMSFGYWTTNFAEVQRALSAKNLSAAKRTPLIAAFPKIFIPLVVVIPGLIALVMEPAIGKTGSGLQYNDAIPVLMRDLLPNGVLGIAVTGLLAAFMAGMAANISSFNTVFTNDLWGAYWKKDRPDAYYLKTGRVVTAVGVLIGMGTAFIASSFSNIMNYLQTLFSFFNVPLFVVFIIGMFWKRTTPAAGFWGLLSGTVAAMVNYFWLYKQNVISIPSDQGANFVSSIVAFVVGSLVMVVVTLVTKPKPVEKLAGLVYGTKSPGIEVPPSEGDDAWYRRPALLGWGAIVLAAICYIPFSF
>NZ_CP045178.1|WP_107502935.1|3434464_3434761_+|hypothetical-protein
MERKSASAARLFDVRRIIGGLFVVYGIIVTIAGITASDADMKKAQDININLWTGLGMLALGLFFVIWQLLRPTVPPTPSEMAEAEAAGAGGAAGPAEQ
>NZ_CP045178.1|WP_077970143.1|3434957_3435653_-|response-regulator-transcription-factor
MSVRLMVVDDHRLLAEALASALKLRGHRVLAAAAPAAGAAELVVTRAPEVCLLGTATPAQPGMFDPVVRIKRERPQVAVLVLGPVPSPRGIAAAFAAGASGYVRHDERIEGVERAIMKARAGEAAVAPLLLQGAFHELLHPVAQPDDEGQRLLSMLTPREVEVLMRVADGEDTRLIAAGMGIAPSTARTHVQRVLMKLGVGSRLEAAALAARTGLLDRADALTPRPEEDRG
>NZ_CP045178.1|WP_077970282.1|3435916_3437881_-|PQQ-binding-like-beta-propeller-repeat-protein
MRKPPPGPVADAPQGQQQPGFGAPRAPQSPPAGFGAPQGPPQQPPSAPGGFGAPTGRPYGHPQSPGAPPAQPGYGFPAGPPQPNNQPGAQPQQPNQPGAHPPMGQQPPQGYAYPQSPPQPPQGYAYPPMQQPPPGYGYPAGQQQPPPPGYGYPGAQQPSYGGYQPPPPTAQVDAGGGGKKPSPVVLIVTAAVVVVALIVGAGVLYATSSDKDDDRSSSAGADADGKGGGDAENGSGGTEKFPSDPASRLSLQVPNPEIAEDDVISAKGSWLAGSVYAKSNVNAVKGYDVSTGKELWNLPLAGQSCAGSRTVGAGGLAAVVYQEAKATKENKYPQCNQISVFDMKTGVKKWTRSVELSGSKASFEEVSISGSTVVVGSGNDGGAGFTLAGGKPIWEPKVSDTCEDIGYAGGPRLVAVHQCGGYEDPKLQVQLLDPATGKAKWTYNVPAGIEDVSILSTKPVVFGAETGDDSVTGVTDAFVLTEKGALATKITLPDGKYAHRCEVNMVDACHDMAVGNNRLYVPTAERRGSGTGVSMTNEIVSFDLTTGKSTGERADAGDDYTLQPLRMDGDRILAYKAAPYDHGGQVVSIDPKTMKQRILLKNPSTESVRDAESSFVSDRAEMLYENGALFIADDLLSKPSSGSQHYVALGFTRE
>NZ_CP045178.1|WP_077970148.1|3439035_3440850_-|ABC-F-family-ATP-binding-cassette-domain-containing-protein
MAVNLVNVEAVSKVYGTRALLDGVSLGVSEGDRIGVVGRNGDGKTTLIRMLAKLEEPDTGRVTHNGGLRTGVLTQYDSLDPAATVRHEVIGDLADHEWAGSAKIRDVLTGLFGGLDLPGFQDGLDTVIGPLSGGERRRIALAKLLIADQDLIVLDEPTNHLDVEGIAWLAEHLRARRSALVCVTHDRWFLDQVCTRMWDVQRGAVYEYEGGYSDYVFARAERERIAATEETKRQNLVRKELAWLRRGAPARTSKPRFRIEAANELIADVPPPRDTSELMKFASSRLGKTVFDLEDVTVEAGPKTLLKHLTWQLGPGDRIGLVGVNGAGKTSLLRALAEAAFSEGEKQPAAGKVVVGRTVKLAYLSQEVTELKPTLRVLEAVQQVRDRVDLGKGREMTAGQLCETFGFNKDKQWTPVGDLSGGERRRLQLLRLLMDEPNVLFLDEPTNDLDIETLTQLEDLLDGWPGSMIVISHDRFFIERTTDRVFALLGDAALRMLPRGIEEYVERRRRMEQAQAATPAAPATGAETRTPAASAKEDRATKKELQRIERQLDRLSQNEAKLHKQIADNATDFEKVAKLDAELRGLAAEKDELEMRWLELAEDA
>NZ_CP045178.1|WP_077970151.1|3441017_3441911_-|4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol-kinase
MSVTVRVPAKVNVQLSVGAARPDGFHDLANVFLAVGLHDEVTVTPADSLRVTCEGPDAAEVPLDRTNLAARAALALAARDGRSPDVHIHIAKDIPVAGGMAGGSADGAGALLACDTLWQTGTPHDELLEICAELGSDVPFSLTGGAALGTGRGERLTRLDVGGVFHWVFAQAEGGLSTPAVYREFDRLHEGHRIPEPLVSPLLLDALASGDPAALAATIGNDLQPAALSLFPALADTLEAGTKAGALAALVSGSGPTTAFLTEDEPSAVAVAEALTASGSCRAVRTATSPAAGATVI
>NZ_CP045178.1|WP_077970283.1|3443454_3445014_-|DUF348-domain-containing-protein
MAERVPEPRGHAPGTWAWATEAPAAEPRAQAPGETNGRTGAHAGRADDRARADAGGREGRVGAHAGEAEASAHAPEDGSPAHGAHARPEASEGAGGRGGGGANSAPSGTASRTRSGTPSGTPSGTPAGTPAGQSGAPVPPSAPARPHRGARRKKSQDRAEPVRRLLPQALVVAFLAGGTSAFVASDKAVSLSVDGVPRTLHTFAGDVEELLDEQGVHVNPHDIVAPAPDATLASGDEIAVRYGRPVDLTLDGQRRTVWTTARTVDGALRQLGVRAQGAHLSASRSSPIARKGLALAVRTERTLTIMADGRERSIRTNAATVGEAVEEAGITLHGHDTTSVPADSFPRDGQTVTVMRITAGKEVREEPVPFATRHEKDPHVYRGTEVVERTGHTGTRRITYAVRTVNGVRQRPKRLSSEIVRAPETRVIKIGTKARPSAVPAADGHNWAALAQCESGGRPGTVDASGTYGGLYQFDTGTWQRLGGSGRPQDAPAGEQTMRAKKLYIQRGASPWPHCGGRL
>NZ_CP045178.1|WP_077970152.1|3445769_3446714_-|TatD-family-deoxyribonuclease
MSSDRPGQQGTPAASANKGKAEQAKKDKDAPPPLPEPLRVAVADSHTHLDMQTGTVEEALAKAASVGVTTLVQVGCDLPGSRWAAETAAVHPAVHATVALHPNEAPRIVLGEPGGEGPRQIERPAGGEAALDEALAEIAGLAALPHVKGVGETGLDFFRTGPEGIAAQERSFRAHIEIAKRYGKALVIHDRDAHADVLRILKEEGAPERTVFHCYSGDAEMAGICAENGWFMSFAGNVTFKNAQRLRDALAVAPLDLVLVETDAPFLTPSPYRGRPNAPYLIPVTVRAMAEVRGIGEDALATALAVNTARAFDY

Crispr_ID: NZ_CP045178_8

• CRISPR_ID: NZ_CP045178_8
• CRISPR_location: 3523389-3523600
• CRISPR_type: Orphan
• Repeat_type: I-C,I-E,II-B
• Spacer_info: 3 spacers

Consensus repeat of NZ_CP045178_8

Consensus_repeat	Method
GTGGTCCCCGCACGTGCGGGGATGGTCCG	PILER-CR
GTGGTCCCCGCACGTGCGGGGATGGTCCG	CRISPRCasFinder
GTGGTCCCCGCACGTGCGGGGATGGTCCG	CRT

spacers of NZ_CP045178_8

>8.1|3523418|32|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT
TACGGGCTGCTCACCGCAGGCTCAGGCTTTGA
>8.2|3523479|32|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT
GTGGTGACCAAGTCGCTTTGTCGTCACCACCG
>8.3|3523540|32|NZ_CP045178|CRISPRCasFinder,CRT
CTCTTCCGTGATGACTCCGGCGTCCTTGCGAC

CRISPR arrays and Neighbor proteins around NZ_CP045178_8

CRISPR arrays

The CRISPR arrays of NZ_CP045178_8

>merge|NZ_CP045178|8|3523389-3523600|PILER-CR,CRISPRCasFinder,CRT
GTGGTCCCCGCACGTGCGGGGATGGTCCGTACGGGCTGCTCACCGCAGGCTCAGGCTTTGAGTGGTCCCCGCACGTGCGGGGATGGTCCGGTGGTGACCAAGTCGCTTTGTCGTCACCACCGGTGGTCCCCGCACGTGCGGGGATGGTCCGCTCTTCCGTGATGACTCCGGCGTCCTTGCGACGTGGTCCCCGCACGTGCGAGGTTTCGTTC

>NZ_CP045178|8|2|3523389-3523539|PILER-CR
GTGGTCCCCGCACGTGCGGGGATGGTCCG	TACGGGCTGCTCACCGCAGGCTCAGGCTTTGA
GTGGTCCCCGCACGTGCGGGGATGGTCCG	GTGGTGACCAAGTCGCTTTGTCGTCACCACCG
GTGGTCCCCGCACGTGCGGGGATGGTCCG

>NZ_CP045178|8|6|3523389-3523600|CRISPRCasFinder
GTGGTCCCCGCACGTGCGGGGATGGTCCG	TACGGGCTGCTCACCGCAGGCTCAGGCTTTGA
GTGGTCCCCGCACGTGCGGGGATGGTCCG	GTGGTGACCAAGTCGCTTTGTCGTCACCACCG
GTGGTCCCCGCACGTGCGGGGATGGTCCG	CTCTTCCGTGATGACTCCGGCGTCCTTGCGAC
GTGGTCCCCGCACGTGCGAGGTTTCGTTC

>NZ_CP045178|8|2|3523389-3523600|CRT
GTGGTCCCCGCACGTGCGGGGATGGTCCG	TACGGGCTGCTCACCGCAGGCTCAGGCTTTGA
GTGGTCCCCGCACGTGCGGGGATGGTCCG	GTGGTGACCAAGTCGCTTTGTCGTCACCACCG
GTGGTCCCCGCACGTGCGGGGATGGTCCG	CTCTTCCGTGATGACTCCGGCGTCCTTGCGAC
GTGGTCCCCGCACGTGCGAGGTTTCGTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077970259.1|3511203_3512010_-|dioxygenase	unknown	unknown	gnl|CDD|153375
NZ_CP045178.1|WP_077973691.1|3529135_3529888_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|187602
NZ_CP045178.1|WP_077970272.1|3522092_3522755_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|223943
NZ_CP045178.1|WP_107502939.1|3525241_3526111_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973603.1|3531072_3532221_+|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377630
NZ_CP045178.1|WP_143621370.1|3526353_3526929_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973599.1|3528887_3529115_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970262.1|3515219_3515885_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP045178.1|WP_077973601.1|3530419_3530842_+|VOC-family-protein	unknown	unknown	gnl|CDD|319899
NZ_CP045178.1|WP_107502938.1|3516295_3517591_+|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|274507
NZ_CP045178.1|WP_077973608.1|3533119_3533548_+|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl|CDD|274340
NZ_CP045178.1|WP_107502937.1|3512456_3512933_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP045178.1|WP_077970303.1|3523826_3524099_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970270.1|3520894_3522112_+|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
NZ_CP045178.1|WP_077970257.1|3509891_3511124_+|DUF4243-domain-containing-protein	unknown	unknown	gnl|CDD|372882
NZ_CP045178.1|WP_077970268.1|3520026_3520374_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970313.1|3524405_3525071_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973605.1|3532328_3532961_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
NZ_CP045178.1|WP_077970301.1|3513070_3514648_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
NZ_CP045178.1|WP_077970266.1|3518856_3519678_-|phosphotransferase	unknown	unknown	gnl|CDD|270690

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077970259.1|3511203_3512010_-|dioxygenase	gnl|CDD|153375	cd07363, 45_DOPA_Dioxygenase, The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine. This subfamily is composed of plant 4,5-DOPA Dioxygenase, the uncharacterized Escherichia coli protein Jw3007, and similar proteins. 4,5-DOPA Dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA Dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain. Homologs of DODA are present not only in betalain-producing plants but also in bacteria and archaea. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.	1.11482e-106
NZ_CP045178.1|WP_077970272.1|3522092_3522755_-|HAD-family-hydrolase	gnl|CDD|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	2.50416e-23
NZ_CP045178.1|WP_077973603.1|3531072_3532221_+|winged-helix-DNA-binding-domain-containing-protein	gnl|CDD|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	3.89445e-54
NZ_CP045178.1|WP_077973691.1|3529135_3529888_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.00687e-30
NZ_CP045178.1|WP_077973601.1|3530419_3530842_+|VOC-family-protein	gnl|CDD|319899	cd06588, PhnB_like, Escherichia coli PhnB and similar proteins. The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.	3.79382e-33
NZ_CP045178.1|WP_107502938.1|3516295_3517591_+|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.18641e-54
NZ_CP045178.1|WP_077973608.1|3533119_3533548_+|TraR/DksA-family-transcriptional-regulator	gnl|CDD|274340	TIGR02890, conserved_hypothetical_protein, regulatory protein, yteA family. Members of this predicted regulatory protein are found only in endospore-forming members of the Firmicutes group of bacteria, and in nearly every such species; Clostridium perfringens seems to be an exception. The member from Bacillus subtilis, the model system for the study of the sporulation program, has been designated both yteA and yzwB. Some (but not all) members of this family show a strong sequence match to Pfam family pfam01258 the C4-type zinc finger protein, DksA/TraR family, but only one of the four key Cys residues is conserved. All members of this protein family share an additional C-terminal domain. Smaller proteins from the proteobacteria with just the N-terminal domain, including DksA and DksA2 are RNA polymerase-binding regulatory proteins even if the Zn-binding site is not conserved. [Unknown function, General].	8.39639e-16
NZ_CP045178.1|WP_107502937.1|3512456_3512933_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	9.3687e-16
NZ_CP045178.1|WP_077970262.1|3515219_3515885_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.24881e-09
NZ_CP045178.1|WP_077970270.1|3520894_3522112_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	8.82092e-05
NZ_CP045178.1|WP_077970257.1|3509891_3511124_+|DUF4243-domain-containing-protein	gnl|CDD|372882	pfam14027, DUF4243, Protein of unknown function (DUF4243). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 348 and 477 amino acids in length.	3.72538e-07
NZ_CP045178.1|WP_077973605.1|3532328_3532961_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.03362e-09
NZ_CP045178.1|WP_077970301.1|3513070_3514648_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.19297e-67
NZ_CP045178.1|WP_077970266.1|3518856_3519678_-|phosphotransferase	gnl|CDD|270690	cd05120, APH_ChoK_like, Aminoglycoside 3'-phosphotransferase and Choline Kinase family. This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	1.14821e-06

Protein sequences

>NZ_CP045178.1|WP_077970272.1|3522092_3522755_-|HAD-family-hydrolase
MIRAVVFDVGECLVDETREYGTWADWLNVPRHTFAAMFGAVIAQGRDYRDVFQEFQPGFDLYSERQKRAEAGRPEHFDESDLYPDVRGALRTLRADGLWLGIAGNQTVRAGKILRELFSQDVDLIGTSDDWGASKPEPEFFRRVAEVVPAEPGEILYVGDRVDNDLRPGAAAGMKTALVHRGPWATIQWQSEEAEKLPTFRVESLLELSPSVARFNAQGH
>NZ_CP045178.1|WP_077970270.1|3520894_3522112_+|helix-turn-helix-transcriptional-regulator
MPRSGNSRLKAARIAAGYPSQQALADALGVGVRQVRRWESDAPPWPQGDVQQALTRTLGQDLQSLGFTPPGVAPPRRTVLAGSIGAVGLAAVPTQVATTMQPASVSQDFASVTRSHRRLYWSVAPATLHPAAVAHAALGHSLLTETAGQTRASVAASLSETLLLVGRIEFFDQQQPERASATWLRALQAAGEADDPLLGAAVLAHTAFIPGWSGDRASAVERMVAARTYGRRGRASAELLAWLDAVEAECETRCGHTQTALHLIGHAEDLLRRGGDIASPEWLDWFSPVRLAAFKGNTQLKAGHLPHARTTLLAALDALPTAEEKQATVLLGDLASVEAAAGHPEAACEYAVRALDQLARTWYAVGMDRVRDVRRSLAPHQHEQCVRDLDDRLYGWSTTVSALAR
>NZ_CP045178.1|WP_077970268.1|3520026_3520374_-|hypothetical-protein
MIPQGDAMSALIEEALLRGPLPGYVRVAELNAILRTELERLTPIVRARADARPDGSPLYREMRWALINAKHILACGPGDGLVSAVRHVRGLAQHTRVLRSYEEPGGTRGCADPLS
>NZ_CP045178.1|WP_077970266.1|3518856_3519678_-|phosphotransferase
MIERVEWDRLPGGVREAVQERVGRVAASEVHQQGLNCSVALTLHAAAGRTFMKGVRAEDTDGAEALAREELVNPFVCAVGPAAWHAVHTDGWSLLLFDHVDGRNADLAPGSADLGPVADALRRMSRIAGASLQGVERLVDRLGQFLTDEEAARLDGDHLLHTDTNPHNLMIDGAGRAHVVDWAMPALGPVWVDAACTAVRLMEDGHSPKTALAWLNAIESWQRAAPAAVAAFVAGTCRHWTARVGEKGALPSNTRFQYLLVGVPHPATCTPPH
>NZ_CP045178.1|WP_107502938.1|3516295_3517591_+|M6-family-metalloprotease-domain-containing-protein
MSRTRPATGRIGRTRRYVALSSLAALTLAIGFTTSASTGQLMDTSATAAGPVSTARATALGPCMISGALGVQMSEGLPTGPGYTRSTGTVHALTLMIDFSDAPGEGSADARLAEFFPQTSEWFRTSSYGRLDYRPEVPVKGWLRMPKPFAAYGIERGAPFEPGYRDLVNDLVATADPEVDFREYDMVNVLVTPNAGPSALDTVLSVTFAGNQEAPIADGVPISNASFVYSRQDDGSGSYTQTGYRVLPHENGHVFGLPDLYTQNGGGAAGHWDIMSEDWGASNDLFAWHKWKLGWLDDNQVSCASAPGATEHKLTPLAERGGTKLAFVPLNSKSGYAIELRTHAGNDEAVCRPGVLIYRVNANVDTGRGPIKVMDSTKDSGGCTRRPNVQAELSDATYTPGETFTDKKRHISIAVTSAGKSGEYRVRVTRP
>NZ_CP045178.1|WP_077970262.1|3515219_3515885_-|TetR/AcrR-family-transcriptional-regulator
MTKGSAAVGAATTVQRRAARPRADALRNRERIVTAAREMIVEHGTEVPLDEVARRAGVGNATLYRHFPDRDDLMGYVVLSVMDRIAALVEEALAEDADAFDGLRRFAHAAVDERIGAICPMLSAAFSEDHPDLLATRDRLDSGVRTIMERARAAGQLRDDVTVGDLLVSLTQLTRPLPGTCCVGNDRFVHRHLQLFLDGLRAPARSVLPGEAVTLEALRGC
>NZ_CP045178.1|WP_077970301.1|3513070_3514648_-|MFS-transporter
MSKTARTSGTPAGLAVDPALPDPRRWKALVFIALAQLMVVLDSTIVNIALPHAQTDLGISDANRQWVITAYALAFGGLLLFGGRIADMWGRKRTFMIGLIGFALASALGGAATGQVMMFGSRALQGVFGALLAPAALSLLAVSFTQAKERAKAFGIFGAIAGGGGAVGLILGGFLTEYLNWRWTFFVNVPFAVVALVGAYFVIREPVGSRNRASLDIPGVVLSTLGLVSLVYGFTRAESAGWSDPVTIGMFVASAVLLGAFLITESKVKAPLLPLRVVTDRNRGGVYASLGLAIIAMFGLFLFLTFYLQVVKGYSPVKTGFAFLPMVAGMITGSTQIGARLMNRVPPRFLMGPGFILAAGGMLVLTQMEIGSNYATLVLPAILMLGLGMGTAFMPAMSLATHGVQPRDAGVASAMVNTSQQVGGAIGTALLNTIAASATTAYLTSHAAGASNAKLLQAQAMVNGYSHAIWWAVGILLVAAAIALTLINTGHQGGPVASGGGDNKGADADLDAEIEDEFLVPVIAH
>NZ_CP045178.1|WP_107502937.1|3512456_3512933_+|MarR-family-transcriptional-regulator
MSDEEQHTWQAYLHATTLLEDHLDRQLQRDAKMPHVYYGLLAQLSGAPHGRLRMTELAKNAKITRSRLSHAVARLEGNGWVRREDCPSDKRGQFAVLTDDGRAMLREIAPGHVAAVRQALFDRLTSQQQQSLGEIMRIIAGGLQPGGTGADADLPWLR
>NZ_CP045178.1|WP_077970259.1|3511203_3512010_-|dioxygenase
MTTASASAPGRMPTLYLSHGAPPLADDPVWPGELADWSETLPVPKSVLMVSAHWEEAPLALSATTTEPLVYDFWGFPEHYYRVRYEAPGAPRLADSVRKLLRGAGTPVQDMPDRGLDHGAYVPLVEMYPDADIPVLQMSLPTLDPRRLMDIGRKLAPLRDEGVLIVGSGFFTHNLAALRHDGTPGWSAEFDDWGHRALDKGDVDALLDFERKSPAGRLAHPRTEHFAPLFVTMGAADAVGELDTQRSVIDGFWMGLAKRSVQFGRQTQ
>NZ_CP045178.1|WP_077970257.1|3509891_3511124_+|DUF4243-domain-containing-protein
MAEDAGPSVVRREDDGALDEALQRLHALGPEYRGRLSNHGPMVVEALVRGGDSASVHRWLDHYRCKLEDLPTAGDPVTDANWREALGRTGRFTDWTRYFEQRAAEHPWRSVLAEWWPRLLPGIAEGSTHPVIRTGHAVRTLLSDEATGAGAPTAPRLTELAHALGYWAARSRPLPRIASFPAPRSAASALAAVPLVREQEGSLPERFAQITALPSWPAPGTPPSLTHRASAGDPGVDRGSDTDTSGLNGPGLDTSGLNGPRPNSPGLNGSALNGSDAEALLKELVEAAVHRYLTHGHGEPVMLVHSATAPNAVLRVLPALPRELWPASLAAAWTASAAVTAAYTLSVAEARPAARVLERAGAPAPEEISARAAAHGNDHAIKFADTALDVGGPLARAAALRAVELAEPFF
>NZ_CP045178.1|WP_077970303.1|3523826_3524099_-|hypothetical-protein
MDFAALAVAAVTLVGGFLTFNQSRAANRRADFTTITERLDRELKDERTQRKLLTSYVIELWRWGGRVGPDTPGGPPPDPPADLDLTPWRQ
>NZ_CP045178.1|WP_077970313.1|3524405_3525071_+|hypothetical-protein
MNRRPNLLAVAALTAVAALSLSACGSGDDSSAGDRSKGSDKIAGADTEEGAASPTASASAASGRPKVELPSDLTYTFDWSKTGDKEKDAVLADSEQFVKSVDMAIAEQDPHGKAYRFYSEGEAAAGSQKFIQEFVDYKDRITGAKRYYNANVKINSDGTAGFVYCEDQNKAYNKSLKTGKADVTPASKDNYVLYSSRLRAKKGVWITETLTAQRGSAACRS
>NZ_CP045178.1|WP_107502939.1|3525241_3526111_+|hypothetical-protein
MIIFDRSKNGKGGSTGAVTSTSSWTPPPCYYAPKYTPKEIEAQMRQVWESSAPSPEWSLKTQNYFVKGNPYKDFNEDKKGQGYWWDSYVTEGRELDPASQDCDEMPFWVDKGDAPPADVPQSITSEMLAQLAYAEIRVPSTAVDLAPDGTTKVNLPTWAWLDSAKFKPVSVTARVPILDIEATTTAEPVALKIDPGTDDAVTYPASGTCPINADGSIGEPYAKGKADRTPPCGVKYLRSSGDGSYKLRATVTWKIHWTGTGVEGEQALPDGTFGAAQDVIVQEIQAVNR
>NZ_CP045178.1|WP_143621370.1|3526353_3526929_-|hypothetical-protein
MDALTHSGPGYDLTPDDDGWDDSGPGGGRILDAVTHSGPGYAYSLSAATEMAENAALKQRRNKELNDALLEGFDRFRRAVRSLEAAALTEDRGEKNGHRERAVEGFRAYLQHADGAISLALNAAREALGPLDVRPRLALNRLDRMLRKSAIEVRDSINDLEQSERPGERIIRQSQVAVKQATSSWESICHV
>NZ_CP045178.1|WP_077973599.1|3528887_3529115_-|hypothetical-protein
MTGPAPASSASAQVTTGSRGLATRWCALLFKALGEITNHTKPGLTVRELGDTHSGDGGTKGSAGWGTVAAINHRQ
>NZ_CP045178.1|WP_077973691.1|3529135_3529888_-|SDR-family-NAD(P)-dependent-oxidoreductase
MSKVIAVFGAGTGLGASVARRFGREGFRVALVARRGDRLAALAEELAGEGIEATPFTADLSKPEEVPALVEAIRDRLGRIDVIEYGPIGGEQGFTPAAELNAATLQALIPLLVLTPVEVVQAVLPEWRERGDGAFLLTHGYSAAQPMPHLSGLGPVMAATRNYLYSLNAELADKGIYAGTLSIGSLIARSEVTAEAQAAFEAAGDAHHSVVEPDELAERYWDMYVKRDRVEQFYPESLGLTTTQVVATTA
>NZ_CP045178.1|WP_077973601.1|3530419_3530842_+|VOC-family-protein
MSVTTTTHLNFRGDARAALEYYQSVFGGRLAAVTYKDTGNTENENEADWVVWGEVAGDNGFHVMAYDVPSKLPWDRGTHPFFVSVRGDSTDEIDAFWQKLAEGSTVVQPLGPSQWAPLYGMLTDRFGVTWVLDVAAPYNG
>NZ_CP045178.1|WP_077973603.1|3531072_3532221_+|winged-helix-DNA-binding-domain-containing-protein
MTVLSARDLNRATLARQYLLQRTTTPVRDAVAHLCGVQAQAPQEPFTGLWSRLHAFAPGLLDQALTERHVVRTHLMRRTVHLVADNDVLAWRARHDTMLRQRVITTYRSELAGVDPDELAAAGRAVMADRQPRTMSELVQAVRDRWPGPPRRVLGELLVAALIPMAQLPPRGLWQNTAGVRNLPLATWLGRDIDPLPGGAGDSANGDSATNKGDDPVGQQLVRRYLAAYGPAATADIRAWSGLTGLPAAVKAIRDELVTFRDERGRTLLDLPDAPRPSPDTPAPVRFLPAFDNAILGYQDRSRIIDDAHLGLSVAGRRAVLVDGRVAATWTTDERRLSVTPLRPRPFSPAEADAVREEGHELAAFLDQGIDRVEIVAMADPA
>NZ_CP045178.1|WP_077973605.1|3532328_3532961_+|TetR/AcrR-family-transcriptional-regulator
MRADAQRNAEKLRAAAAELFQERGLKVPLKEIARRAGVSHGTLYNLFGTREALIDEVVTDLAVDRLDAAAEHALAFEDAWEGFAHYVERVCELQAADPAVADVVSGRYPHAELLMAVCKQMQDSATRIIERALRAGTLRPDFTAEDIMVLFAIGASLARASTETTPDAWRRPVAFLLDGARAEAARGALPSAPLSSQQMYDVMGGLLGRS
>NZ_CP045178.1|WP_077973608.1|3533119_3533548_+|TraR/DksA-family-transcriptional-regulator
MSDSSRSAAFPSSGQQPPADKGFAASSYPAVRERLLAERGSSDAQIAALSRDFDAIVDANALVAVDDEHDPEGSSTAFERAHVAAMLARTREHLTELDSALERLERGEYGRCAGCGEPIPAERLEARPAAATCVRCAAGRAR

Crispr_ID: NZ_CP045178_9

• CRISPR_ID: NZ_CP045178_9
• CRISPR_location: 3661377-3661500
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_9

Consensus_repeat	Method
CCCGAGCCGCCGGACGGCTGAGCGGCGGGGGC	CRISPRCasFinder

spacers of NZ_CP045178_9

>9.1|3661409|60|NZ_CP045178|CRISPRCasFinder
ACGGTGGGCGCCGGTGGCCACGGCGGTCACAGCCACCACCCTGCGGAGGCAGTCGCATCG

CRISPR arrays and Neighbor proteins around NZ_CP045178_9

CRISPR arrays

The CRISPR arrays of NZ_CP045178_9

>merge|NZ_CP045178|9|3661377-3661500|CRISPRCasFinder
CCCGAGCCGCCGGACGGCTGAGCGGCGGGGGCACGGTGGGCGCCGGTGGCCACGGCGGTCACAGCCACCACCCTGCGGAGGCAGTCGCATCGCCCGAGCCGCCGGACGGCTGAGCGGCGGCGGG

>NZ_CP045178|9|7|3661377-3661500|CRISPRCasFinder
CCCGAGCCGCCGGACGGCTGAGCGGCGGGGGC	ACGGTGGGCGCCGGTGGCCACGGCGGTCACAGCCACCACCCTGCGGAGGCAGTCGCATCG
CCCGAGCCGCCGGACGGCTGAGCGGCGGCGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077973469.1|3658559_3658778_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973461.1|3665896_3666877_+|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl|CDD|235467
NZ_CP045178.1|WP_077973584.1|3659381_3661376_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226482
NZ_CP045178.1|WP_077973477.1|3648217_3649012_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224045
NZ_CP045178.1|WP_077973475.1|3652169_3654689_+|DNA-binding-protein	unknown	unknown	gnl|CDD|379300
NZ_CP045178.1|WP_077973460.1|3669001_3669583_+|hypothetical-protein	unknown	unknown	gnl|CDD|282710
NZ_CP045178.1|WP_077973465.1|3662837_3663485_+|hypothetical-protein	unknown	unknown	gnl|CDD|226789
NZ_CP045178.1|WP_077973463.1|3663711_3663978_-|DUF4031-domain-containing-protein	unknown	unknown	gnl|CDD|379076
NZ_CP045178.1|WP_077973586.1|3650627_3651980_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP045178.1|WP_143621558.1|3668573_3668945_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973471.1|3657441_3658278_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP045178.1|WP_107503031.1|3666943_3668584_+|PTS-alpha-glucoside-transporter-subunit-IIA	unknown	unknown	gnl|CDD|181971
NZ_CP045178.1|WP_077973473.1|3655647_3657291_+|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223989
NZ_CP045178.1|WP_152330769.1|3654634_3655405_-|VanZ-family-protein	unknown	unknown	gnl|CDD|377417
NZ_CP045178.1|WP_143621555.1|3669875_3670139_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973589.1|3645927_3646953_+|iron-ABC-transporter-permease	unknown	unknown	gnl|CDD|376439
NZ_CP045178.1|WP_107503032.1|3664597_3665695_+|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224651
NZ_CP045178.1|WP_107503034.1|3663974_3664358_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973467.1|3661828_3662527_-|copper-homeostasis-protein-CutC	unknown	unknown	gnl|CDD|281866
NZ_CP045178.1|WP_077973588.1|3649254_3650256_+|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238566

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077973461.1|3665896_3666877_+|N-acetylmuramic-acid-6-phosphate-etherase	gnl|CDD|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	6.87887e-154
NZ_CP045178.1|WP_077973584.1|3659381_3661376_+|AAA-family-ATPase	gnl|CDD|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	8.2708e-71
NZ_CP045178.1|WP_077973477.1|3648217_3649012_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.92074e-135
NZ_CP045178.1|WP_152330769.1|3654634_3655405_-|VanZ-family-protein	gnl|CDD|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	3.16688e-29
NZ_CP045178.1|WP_077973463.1|3663711_3663978_-|DUF4031-domain-containing-protein	gnl|CDD|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	1.9029e-33
NZ_CP045178.1|WP_077973465.1|3662837_3663485_+|hypothetical-protein	gnl|CDD|226789	COG4339, COG4339, Uncharacterized protein conserved in bacteria [Function unknown].	2.10103e-46
NZ_CP045178.1|WP_077973460.1|3669001_3669583_+|hypothetical-protein	gnl|CDD|282710	pfam04886, PT, PT repeat. This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.	0.00329807
NZ_CP045178.1|WP_077973586.1|3650627_3651980_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.29964e-06
NZ_CP045178.1|WP_077973471.1|3657441_3658278_-|alpha/beta-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.94323e-49
NZ_CP045178.1|WP_077973473.1|3655647_3657291_+|DEAD/DEAH-box-helicase	gnl|CDD|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	3.79065e-107
NZ_CP045178.1|WP_077973475.1|3652169_3654689_+|DNA-binding-protein	gnl|CDD|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	1.51777e-40
NZ_CP045178.1|WP_077973589.1|3645927_3646953_+|iron-ABC-transporter-permease	gnl|CDD|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.63778e-81
NZ_CP045178.1|WP_107503032.1|3664597_3665695_+|MurR/RpiR-family-transcriptional-regulator	gnl|CDD|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	7.32428e-70
NZ_CP045178.1|WP_107503031.1|3666943_3668584_+|PTS-alpha-glucoside-transporter-subunit-IIA	gnl|CDD|181971	PRK09586, murP, PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed.	2.01217e-101
NZ_CP045178.1|WP_077973467.1|3661828_3662527_-|copper-homeostasis-protein-CutC	gnl|CDD|281866	pfam03932, CutC, CutC family. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	2.15689e-18
NZ_CP045178.1|WP_077973588.1|3649254_3650256_+|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl|CDD|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	4.77769e-66

Protein sequences

>NZ_CP045178.1|WP_077973584.1|3659381_3661376_+|AAA-family-ATPase
MREDAENLNIKDVTANWVNAAVLDAQITERVKSLADLAHTPLFFGRLDYQHAPGGELAEGAHGERFYIGRRHVHDADGDPLVIDWRAPVSQPFYRASKKDPQDVSLRRRFGYTAGDLSAYEDERLTDPEETERTSQLLQREIERPRVGPMRDIVATIQPEQDEIVRGDLSGTVCVQGGPGTGKTAVGLHRVAFLLYAHRERLARTGTLVIGPNKSFLHYIEQVLPALGEMEVKQATVEDLVARVAQVEVAGADEAGAAVVKGDARMAEVLRRAIHSHVTEPSEPVVVVRGSRRWRIPAHEIADIVRELMERDIRYGAAREALPRRIAHSVLVRMEEAGEAPDDRVQDAVARDRAVKAAVKAVWPPVDPARLVLRLLAEPEFLAEHAQGLLNADEQKAILWVKPPRGVKSAKWSAADAVLIDEARDLVERTHSLGHVVLDEAQDLSPMQYRAVGRRCSTGSATVLGDLAQGTTPWATPGWDEALRHLGKPDALVEELTAGFRVPREVIAYASRLLPAIAPGLAEVASVRESPGSLSVRRAAGDRDAAVVEACVESLEHEGSTGLIAADARVPALASALAAAGLSALSPGEETTHESRLTLVPASLAKGLEYDYVVLDEPAAVVAGEPDERTGLRRLYVALTRAVSGLIVTHEGELPERLREGTGA
>NZ_CP045178.1|WP_077973469.1|3658559_3658778_-|hypothetical-protein
MSAATFTPSSVRPGRIRPGPPGPTTASEARPARPALLRAAGAFLGAAVSVVLLGQGSDEEAGVRTGLRHIND
>NZ_CP045178.1|WP_077973471.1|3657441_3658278_-|alpha/beta-hydrolase
MGRIKVGSENSTDIELHYEDKGSGQPVVLIHGYPLDGNSWEGQIPPLLDAGYRVITYDRRGFGKSSQPSTGYDYDTFAADLHTVLETLDLRDAILVGFSMGTGEVARYLSLHGSERVAKAAFLASLEPFLAITDDNPDGAAPLSFFQGVSDAAAKDRYAFFTGFYNDFYNLDDNLGSRISEETVRNSWNIAAGSGFIASAAAPLTWPTDFRADIPRIDVPALIVHGTADRTLPIDATGRRFAKALPAAQYVEIEGAPHGLLATHTAEVNEVLLAFLGK
>NZ_CP045178.1|WP_077973473.1|3655647_3657291_+|DEAD/DEAH-box-helicase
MNGPLIVQSDKTLLLEVDHERADECRRTIAPFAELERAPEHIHTYRITPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMARYGRLTLSKHPTHGLVLTSTDRPVLEEILRSKRVAPLVGDRLGEDTVIVHPSERGQIKQVLLRLGWPAEDLAGYVDGEAHRIDLEEQDWQLRPYQKQAVENFWHGGSGVVVLPCGAGKTLVGAGAMAQASATTLILVTNTVSARQWKHELVRRTSLTEEEIGEYSGTKKEIRPVTIATYQVLTTKRKGVYPHLELFDSRDWGLILYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDTERLAYATAEAEEKYRFCATTATKQKVTEALVRKHQGEQTLVIGQYIDQLDELGEHLGAPVIKGETTNAQREKLFNAFREGELSVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHEARFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIMDSDDLLAGS
>NZ_CP045178.1|WP_152330769.1|3654634_3655405_-|VanZ-family-protein
MAVAFLALVAFSAVLAKLTLTPSPASAGVAGSNMHPGHSLREYVEDYSFLGACKQIIGNLVLGAPFGVLLPVLVPRRLRMIRVVVITLLVMALVELAQGAVVEGRAFDVDDVILNTAGAIVGYVLFGRPLAHLIRGRRRRGSAPAAPGERAARAPVEYGGAGTAGAGAGAGKKTGGAASCPERPRGPGRAPARSSSGGGRTTGRGDGRSRGLARARSCRGPVRTRATRRPGPVKPRVVRQAGSSASSATPVMRCSW
>NZ_CP045178.1|WP_077973475.1|3652169_3654689_+|DNA-binding-protein
MSSPASSQEAAAGTSAHPTTGAAAPRSLAEALRARDDESLSALLRARPDLLTPLPVDLTQLATRAGTRASVVRALERLDRFALQTAEALAVAPDPSPYEVLRDLLAGDDHDPAVTAALPHAVATLREQALVWGADDRLRLVRTARELLAPTPGHPSPTGLGPTVAEATAGMSPGRLQTIQAAAGLPSTHDSVSAVTALTSLFRDRQRMSELLDEAPPEGIEVLGRLVWGPPYGQVTAEPPAHLRWLLDRGLLLATSPGTVVLPREAALHLRAGRAHRVTEPVPPAVVPAALHAPGIVDATAAGQAYSALATVEELLKEWSSPSQGWSKGGATRADGGPAVLRAGGLSLRDLKRTASLLNVSEQAAAFWVELTYTAGLLAPDGEADERYAPTPAYDEWLALSPAERWAPLAMAWLTATRTAGLIGGSDSKDRTLSALGPHLDRSASPEVRRRVLELLAGLDRGAAPDVNSLLARLRWERPLRGAASEGDLRSRIARWTLDESEALGITGRGALSAQAAELLETGDRAEAAAILAGLLPEPLDHVLLQADLTAVAPGPLERPLAETLNVLADIESKGGATVYRFTPASVRRALDAGFSASDLHAFLAARSRTPVPQPLTYLVDDVARRHGQLRVGAAAAYVRCDDDAMLDEILADKRSQTLRLRRLAPTVLAAQADPGTLLDGLRSMGFAPAAESPDGDVMVSRAHERRTPPRTAPEPVPEGPPTPDPTLLAAAVRAVRGGDQAATAPRKPVSEAVRSAGPGELPRTTPSETLATMQAAVMTGETLLIGYVNAEGGATRRVIAPVRVEGGFVTAFDHTAEETRTYQLHRITGVAELADDPA
>NZ_CP045178.1|WP_077973586.1|3650627_3651980_-|hypothetical-protein
MGIESDQLVFDYLSRVGDLAQQRQLPSGTRMRLVTELRGEIDRGRAGAGTPDTPAGVRRILARLGSPDAVVDAAGPGGSAHADSAAPPSPVHAPVPEPGDAGSGGDPGGGRGGRSGSGAGKAGGKVGGLGRGVPGPRKPLKNPLRNALKKPQAPEAGTGRAAGAGAGGAESVPGLSSSAPGAPAPGAPAPDASAPGASGPSADSVFGPGSGSGSGSGSGSGFFFDQEAPDAGSVSLPGQRRGASPPHLAGMEELGSDGSEPDWWRLDSSPFGAGEKVPGFVGGVEIPEILRPPEPTPGPDQQRVVQPVVEAVEVPVPVRRRGLARLRRPAGEAGDAGLGGLSNPLLLLSVALLVVGAVLGNWILLGGGWLIAYASRRLSAAESKWAVFVMPGLVVAGAFVWLWGRQERHWGDPIVQGQMADVLSDTWPWVVRGAAVASAVYVAWRSQKVR
>NZ_CP045178.1|WP_077973588.1|3649254_3650256_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MTRTPGHGRRATLSGALALAGALTLAACSSGPGSGSSPGSGGVGTDAKAGATHTVKTAMGAVQVPGAPKRVVVLDTAELDSVITLGVKPVGATRAGAASDFLGYLPKNQVTGVKNVGEIGNPNLETVAALKPDLILTNKVRDEARYGQLSAIAPTVMTETTGYPWKQNFRVHAEALGRLPEARKAERAYRKQVADVTEAVGGRRKAAATSVNIVRFVEGADIRIYGQKTCIATILGDVGLGRPAITEKAKDGWSYDVSPEKIDLADADVIFHATYGDPRKAKATEVLDSGLWKRLPAVKNHRVTGVDDELWIQGIGYTAAGKILAELESGLTR
>NZ_CP045178.1|WP_077973477.1|3648217_3649012_+|ABC-transporter-ATP-binding-protein
MTARLTTRGLTLAYEERTVVEGLDLDVPDGRVTVIVGPNACGKSTTLRALGRLLKPREGSVLLDGESLATLPTKRIAQRIGLLPQTPVAPDSITVGDLVARGRQPHQHWWQQWSDEDERAVTDAMDRTDVSALADRAVDELSGGQRQRVWIAMALAQETGLLLLDEPTTYLDIAHQVEVLDLVRQLNHDQGRTVVVVLHDLNQAARYADHLVAMKSGEVVAEGAPAEVVTEELVRDVFGLECVVVPDPVTGSPLIVPGAPWSAA
>NZ_CP045178.1|WP_077973589.1|3645927_3646953_+|iron-ABC-transporter-permease
MAAVPSPGRRALLVRRTGWTVAAIVALLLAVLLSLAVGARTIAPSAVLDALLHGGHSDAADVVRSLRLPRTLIGLMVGAALAIAGTALQGITRNPIADPGILGVSQGSSVGVVIAIAFLGVHTLSGYVWFAFPGAAVASVAVYAIAARGRGGATPVKLALGGAAINALLVSVTSGVLTTKASAMEEFRFWNVGSLAGRDSHVVAQVWPFLLVGVVLVVSVARGLDALALGEDVAKGLGQRVATVRVVGGLGATVLTGVGVAAAGPIAFIGLAVPHIARAIVGSDHRWVLPMAALVGPVMLLVSDVIGRVIFPPSEVPAGVMTALIGVPFLVTLVRRKAVAA
>NZ_CP045178.1|WP_077973467.1|3661828_3662527_-|copper-homeostasis-protein-CutC
MSKRAVLEVIALDAVDAIAAQAGGADRLELVTDMAADGLTPSREEFARIRAAVDISLRVMLRASDGFSAGGPAELDALVRRAAELRSEGADEFVLGFLADDGGPDLDAVGALLDVVDGCRWTFHRAIDRAADRDVLRKRLAELPGLDTYLSAGSPAGVDDGLDVLKSEAGRGDEPGYTQQLLVGGGLHLHHVPGLRAAGVSAFHIGGASRPRGWDAPVDAEAVREWRVAVGE
>NZ_CP045178.1|WP_077973465.1|3662837_3663485_+|hypothetical-protein
MSVMADDLRSRWLRTLRRARAGGPGPDPAPYAENLLARWAEPQRVYHSTDHLVAVLDHVDTLAEHAEDADAVRLAAWFHDAVYRPDRSENEERSAALAERALTEAGVPAPRTAEVARLVRLTVTHDPAEGDTDGEVLCDADLAVLAGAPDAYAAYASAVRAEYAFVPDEAFREGRASVLRQLLALPRLFRTPYGTREWEARARQNLATELELLRA
>NZ_CP045178.1|WP_077973463.1|3663711_3663978_-|DUF4031-domain-containing-protein
MTVYIDPPNWPGHGRMWSHLVSDVSYAELHAFADILGVPRRAFDGDHYDIPSHRYADAVAAGAVATGSKELVRRLIGAGLRRRKRRAV
>NZ_CP045178.1|WP_107503034.1|3663974_3664358_-|hypothetical-protein
MPVEPLERTLHAARALVLADLAVGEIADAHVVSMVEESVTQRRWWVEQWPEGAEFVPGLVAQDVKDALLDQHGRWPLCPVCAEGEPHALDVEPELGPDPHWVCHEAGIVVAPVGLLATVPGLGGPAE
>NZ_CP045178.1|WP_107503032.1|3664597_3665695_+|MurR/RpiR-family-transcriptional-regulator
MGRQEGLDAFPGRKYLSFVTEEVKESFISANRSANGGANGSAPRNGTGTGTRSTPRTGSGNGRQNPTRTPPAPAALAAKVRTIAPTMTRSMQRVAEAVAADPAGCAALTVTGLAEHTRTSEATVVRTARLLGYPGYRDLRLALAGLAAHQESGRPPTVTADIAVDDSLADVVAKLAHDERQTLADTAAGLDPVQLGAAVTALAAARRTDIYGVGASGLVAQDLAQKLLRIGMIAHAHSDPHLAVTNAVQLGARDVAVAITHSGATGDVIEPLRVAFDQGTTTIAITGRPDGSVSQYADHILTTSTARESELRPAAMSSRTSQLLVVDCLFVGVAQRTYERAAPALAASYEALAHRHTPRSPQSHR
>NZ_CP045178.1|WP_077973461.1|3665896_3666877_+|N-acetylmuramic-acid-6-phosphate-etherase
MTTTTGANHDGNTSHGNTSHGGLRAQLDTLTTEAFRPELAEIDMLSTEEIARTMNGEDATVPAAVAARVPEIAAAIDATAERMARGGRLVYAGAGSAGRTGVMDASECPPTFNTAPGQVVGLIAGGPSAMVTSVEGAEDSKELAAADLDALGLTSDDVVVGVSASGRTPYAIGAVEHARHTYGALTIGLSCNAGSALAAAADHGIEVVVGPELLTGSTRLKSGTAQKLVLNMISTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGADDDEVEAALTATGGEVKNAILVVLGGVDGATSARLLDESRGGLRAALTAARAE
>NZ_CP045178.1|WP_107503031.1|3666943_3668584_+|PTS-alpha-glucoside-transporter-subunit-IIA
MAENKNRDTAAAILPLVGGAANVTSVVHCMTRLRLGLRDRSLVREEALRALPAVLGVVEDETYQIVLGPGVVARVTPEFEALVAEAWRAAPGRAPEGPAVEGGPADGPASAPAPTPTTPPPPSSPPPPSSPSPPSPPPVIGAEELAGRGAELRAARKARNATPVKLFLRRIADIFVPLIPALIGCGIIAGLNGLLVNLGWLGSVTPALSAVASGFMALIAVFVGYNTAKEFGGTPVLGGAVAAIIVYAGVAEIDVFGQRLAPGQGGVLGALGAAVLASYIERWCRTWVPEAIDVLVTPTLTVLLAGLVTLYGLMFAAGEVASAIGTGANWLLDNTGAFAGLVLGGLFLPLVMLGLHQALIPIHTTLIEQQGYTVLLPILAMAGAGQVGCAMAVYLRLRHNDSIRKTIRSALPAGLLGVGEPLIYGVSLPLGRPFVTACVGGAAGGAFVGLFSMLGDKVGSTAIGPSGWALFPLLKGNQGLGTVAAVYGLGLLLGYVVGFAATYAFGFSREMLAELNAPPRARATDGTTAAPPVPARPEPVAETPTP
>NZ_CP045178.1|WP_143621558.1|3668573_3668945_-|hypothetical-protein
MTGRRVPHPRPIRNPEARGRPAGLAEALLAGAFVLAVLMNLTRSVVEPGGVLWGAARVVVAVLFAAGLVWFAGARARRATQARGPLEARQARQPWEARQAREAWQPRQSRETRSGRSHVRPTA
>NZ_CP045178.1|WP_077973460.1|3669001_3669583_+|hypothetical-protein
MARPFERCYVPDMPSAEEKHPGQPTGQPTGQPAGQPAGQPSDRPEEAIPEEAIPEEATPDGPAPADAIPEDVLTRVGETVVRWAAEWGEDDLRRIAIVATTRDAATRWIMGGRVRSTDERVYLAVVRGTFGRHVEGTDRFTTGAWAALFIDRTSLHVTGMNLRPMDYAPETGPTPLGRVYDLRGADFSDGNGK
>NZ_CP045178.1|WP_143621555.1|3669875_3670139_-|hypothetical-protein
MADALRDRLRGYIQALADPADAYAHRLADNRAKDIALSTVVHARAVAADRGGDPVASLRLLGKSAEILSRYTAAARPLPAPPSGRCP

Crispr_ID: NZ_CP045178_10

• CRISPR_ID: NZ_CP045178_10
• CRISPR_location: 3663472-3663572
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_10

Consensus_repeat	Method
TGCTCAGGGCGTGAGCGAATTGAGCC	CRISPRCasFinder

spacers of NZ_CP045178_10

>10.1|3663498|49|NZ_CP045178|CRISPRCasFinder
ACTCAGGGCGTGTACGAAGCGGGTTGCTCAGGACGTGTACGAAGCGGAT

CRISPR arrays and Neighbor proteins around NZ_CP045178_10

CRISPR arrays

The CRISPR arrays of NZ_CP045178_10

>merge|NZ_CP045178|10|3663472-3663572|CRISPRCasFinder
TGCTCAGGGCGTGAGCGAATTGAGCCACTCAGGGCGTGTACGAAGCGGGTTGCTCAGGACGTGTACGAAGCGGATTGCTCAGGGCGTGAGCGACTTGAGCC

>NZ_CP045178|10|8|3663472-3663572|CRISPRCasFinder
TGCTCAGGGCGTGAGCGAATTGAGCC	ACTCAGGGCGTGTACGAAGCGGGTTGCTCAGGACGTGTACGAAGCGGAT
TGCTCAGGGCGTGAGCGACTTGAGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077973469.1|3658559_3658778_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973461.1|3665896_3666877_+|N-acetylmuramic-acid-6-phosphate-etherase	unknown	unknown	gnl|CDD|235467
NZ_CP045178.1|WP_077973584.1|3659381_3661376_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|226482
NZ_CP045178.1|WP_077973477.1|3648217_3649012_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224045
NZ_CP045178.1|WP_143621552.1|3670214_3671081_+|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|379262
NZ_CP045178.1|WP_077973577.1|3671086_3671305_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP045178.1|WP_077973463.1|3663711_3663978_-|DUF4031-domain-containing-protein	unknown	unknown	gnl|CDD|379076
NZ_CP045178.1|WP_077973475.1|3652169_3654689_+|DNA-binding-protein	unknown	unknown	gnl|CDD|379300
NZ_CP045178.1|WP_077973460.1|3669001_3669583_+|hypothetical-protein	unknown	unknown	gnl|CDD|282710
NZ_CP045178.1|WP_077973586.1|3650627_3651980_-|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP045178.1|WP_143621558.1|3668573_3668945_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973471.1|3657441_3658278_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|366166
NZ_CP045178.1|WP_107503031.1|3666943_3668584_+|PTS-alpha-glucoside-transporter-subunit-IIA	unknown	unknown	gnl|CDD|181971
NZ_CP045178.1|WP_077973473.1|3655647_3657291_+|DEAD/DEAH-box-helicase	unknown	unknown	gnl|CDD|223989
NZ_CP045178.1|WP_152330769.1|3654634_3655405_-|VanZ-family-protein	unknown	unknown	gnl|CDD|377417
NZ_CP045178.1|WP_143621555.1|3669875_3670139_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_107503032.1|3664597_3665695_+|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224651
NZ_CP045178.1|WP_107503034.1|3663974_3664358_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077973467.1|3661828_3662527_-|copper-homeostasis-protein-CutC	unknown	unknown	gnl|CDD|281866
NZ_CP045178.1|WP_077973588.1|3649254_3650256_+|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238566

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077973461.1|3665896_3666877_+|N-acetylmuramic-acid-6-phosphate-etherase	gnl|CDD|235467	PRK05441, murQ, N-acetylmuramic acid-6-phosphate etherase; Reviewed.	6.87887e-154
NZ_CP045178.1|WP_077973584.1|3659381_3661376_+|AAA-family-ATPase	gnl|CDD|226482	COG3973, COG3973, Superfamily I DNA and RNA helicases [General function prediction only].	8.2708e-71
NZ_CP045178.1|WP_077973477.1|3648217_3649012_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.92074e-135
NZ_CP045178.1|WP_143621552.1|3670214_3671081_+|helix-turn-helix-domain-containing-protein	gnl|CDD|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	1.80393e-10
NZ_CP045178.1|WP_077973577.1|3671086_3671305_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	2.39183e-16
NZ_CP045178.1|WP_077973463.1|3663711_3663978_-|DUF4031-domain-containing-protein	gnl|CDD|379076	pfam13223, DUF4031, Protein of unknown function (DUF4031). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	1.9029e-33
NZ_CP045178.1|WP_077973475.1|3652169_3654689_+|DNA-binding-protein	gnl|CDD|379300	pfam13625, Helicase_C_3, Helicase conserved C-terminal domain. This domain family is found in a wide variety of helicases and helicase-related proteins.	1.51777e-40
NZ_CP045178.1|WP_077973460.1|3669001_3669583_+|hypothetical-protein	gnl|CDD|282710	pfam04886, PT, PT repeat. This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.	0.00329807
NZ_CP045178.1|WP_077973586.1|3650627_3651980_-|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	1.29964e-06
NZ_CP045178.1|WP_077973471.1|3657441_3658278_-|alpha/beta-hydrolase	gnl|CDD|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.94323e-49
NZ_CP045178.1|WP_077973473.1|3655647_3657291_+|DEAD/DEAH-box-helicase	gnl|CDD|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	3.79065e-107
NZ_CP045178.1|WP_152330769.1|3654634_3655405_-|VanZ-family-protein	gnl|CDD|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	3.16688e-29
NZ_CP045178.1|WP_107503032.1|3664597_3665695_+|MurR/RpiR-family-transcriptional-regulator	gnl|CDD|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	7.32428e-70
NZ_CP045178.1|WP_107503031.1|3666943_3668584_+|PTS-alpha-glucoside-transporter-subunit-IIA	gnl|CDD|181971	PRK09586, murP, PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed.	2.01217e-101
NZ_CP045178.1|WP_077973467.1|3661828_3662527_-|copper-homeostasis-protein-CutC	gnl|CDD|281866	pfam03932, CutC, CutC family. Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	2.15689e-18
NZ_CP045178.1|WP_077973588.1|3649254_3650256_+|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl|CDD|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	4.77769e-66

Protein sequences

>NZ_CP045178.1|WP_077973467.1|3661828_3662527_-|copper-homeostasis-protein-CutC
MSKRAVLEVIALDAVDAIAAQAGGADRLELVTDMAADGLTPSREEFARIRAAVDISLRVMLRASDGFSAGGPAELDALVRRAAELRSEGADEFVLGFLADDGGPDLDAVGALLDVVDGCRWTFHRAIDRAADRDVLRKRLAELPGLDTYLSAGSPAGVDDGLDVLKSEAGRGDEPGYTQQLLVGGGLHLHHVPGLRAAGVSAFHIGGASRPRGWDAPVDAEAVREWRVAVGE
>NZ_CP045178.1|WP_077973584.1|3659381_3661376_+|AAA-family-ATPase
MREDAENLNIKDVTANWVNAAVLDAQITERVKSLADLAHTPLFFGRLDYQHAPGGELAEGAHGERFYIGRRHVHDADGDPLVIDWRAPVSQPFYRASKKDPQDVSLRRRFGYTAGDLSAYEDERLTDPEETERTSQLLQREIERPRVGPMRDIVATIQPEQDEIVRGDLSGTVCVQGGPGTGKTAVGLHRVAFLLYAHRERLARTGTLVIGPNKSFLHYIEQVLPALGEMEVKQATVEDLVARVAQVEVAGADEAGAAVVKGDARMAEVLRRAIHSHVTEPSEPVVVVRGSRRWRIPAHEIADIVRELMERDIRYGAAREALPRRIAHSVLVRMEEAGEAPDDRVQDAVARDRAVKAAVKAVWPPVDPARLVLRLLAEPEFLAEHAQGLLNADEQKAILWVKPPRGVKSAKWSAADAVLIDEARDLVERTHSLGHVVLDEAQDLSPMQYRAVGRRCSTGSATVLGDLAQGTTPWATPGWDEALRHLGKPDALVEELTAGFRVPREVIAYASRLLPAIAPGLAEVASVRESPGSLSVRRAAGDRDAAVVEACVESLEHEGSTGLIAADARVPALASALAAAGLSALSPGEETTHESRLTLVPASLAKGLEYDYVVLDEPAAVVAGEPDERTGLRRLYVALTRAVSGLIVTHEGELPERLREGTGA
>NZ_CP045178.1|WP_077973469.1|3658559_3658778_-|hypothetical-protein
MSAATFTPSSVRPGRIRPGPPGPTTASEARPARPALLRAAGAFLGAAVSVVLLGQGSDEEAGVRTGLRHIND
>NZ_CP045178.1|WP_077973471.1|3657441_3658278_-|alpha/beta-hydrolase
MGRIKVGSENSTDIELHYEDKGSGQPVVLIHGYPLDGNSWEGQIPPLLDAGYRVITYDRRGFGKSSQPSTGYDYDTFAADLHTVLETLDLRDAILVGFSMGTGEVARYLSLHGSERVAKAAFLASLEPFLAITDDNPDGAAPLSFFQGVSDAAAKDRYAFFTGFYNDFYNLDDNLGSRISEETVRNSWNIAAGSGFIASAAAPLTWPTDFRADIPRIDVPALIVHGTADRTLPIDATGRRFAKALPAAQYVEIEGAPHGLLATHTAEVNEVLLAFLGK
>NZ_CP045178.1|WP_077973473.1|3655647_3657291_+|DEAD/DEAH-box-helicase
MNGPLIVQSDKTLLLEVDHERADECRRTIAPFAELERAPEHIHTYRITPLGLWNARAAGHDAEQVVDALVEYSRYPVPHALLVDIAETMARYGRLTLSKHPTHGLVLTSTDRPVLEEILRSKRVAPLVGDRLGEDTVIVHPSERGQIKQVLLRLGWPAEDLAGYVDGEAHRIDLEEQDWQLRPYQKQAVENFWHGGSGVVVLPCGAGKTLVGAGAMAQASATTLILVTNTVSARQWKHELVRRTSLTEEEIGEYSGTKKEIRPVTIATYQVLTTKRKGVYPHLELFDSRDWGLILYDEVHLLPAPVFKFTADLQARRRLGLTATLVREDGRESDVFSLIGPKRFDAPWKEIEAQGYIAPADCVEVRVNLTDTERLAYATAEAEEKYRFCATTATKQKVTEALVRKHQGEQTLVIGQYIDQLDELGEHLGAPVIKGETTNAQREKLFNAFREGELSVLVVSKVANFSIDLPEATVAIQVSGTFGSRQEEAQRLGRVLRPKADGHEARFYSVVARDTIDQDFAAHRQRFLAEQGYAYRIMDSDDLLAGS
>NZ_CP045178.1|WP_152330769.1|3654634_3655405_-|VanZ-family-protein
MAVAFLALVAFSAVLAKLTLTPSPASAGVAGSNMHPGHSLREYVEDYSFLGACKQIIGNLVLGAPFGVLLPVLVPRRLRMIRVVVITLLVMALVELAQGAVVEGRAFDVDDVILNTAGAIVGYVLFGRPLAHLIRGRRRRGSAPAAPGERAARAPVEYGGAGTAGAGAGAGKKTGGAASCPERPRGPGRAPARSSSGGGRTTGRGDGRSRGLARARSCRGPVRTRATRRPGPVKPRVVRQAGSSASSATPVMRCSW
>NZ_CP045178.1|WP_077973475.1|3652169_3654689_+|DNA-binding-protein
MSSPASSQEAAAGTSAHPTTGAAAPRSLAEALRARDDESLSALLRARPDLLTPLPVDLTQLATRAGTRASVVRALERLDRFALQTAEALAVAPDPSPYEVLRDLLAGDDHDPAVTAALPHAVATLREQALVWGADDRLRLVRTARELLAPTPGHPSPTGLGPTVAEATAGMSPGRLQTIQAAAGLPSTHDSVSAVTALTSLFRDRQRMSELLDEAPPEGIEVLGRLVWGPPYGQVTAEPPAHLRWLLDRGLLLATSPGTVVLPREAALHLRAGRAHRVTEPVPPAVVPAALHAPGIVDATAAGQAYSALATVEELLKEWSSPSQGWSKGGATRADGGPAVLRAGGLSLRDLKRTASLLNVSEQAAAFWVELTYTAGLLAPDGEADERYAPTPAYDEWLALSPAERWAPLAMAWLTATRTAGLIGGSDSKDRTLSALGPHLDRSASPEVRRRVLELLAGLDRGAAPDVNSLLARLRWERPLRGAASEGDLRSRIARWTLDESEALGITGRGALSAQAAELLETGDRAEAAAILAGLLPEPLDHVLLQADLTAVAPGPLERPLAETLNVLADIESKGGATVYRFTPASVRRALDAGFSASDLHAFLAARSRTPVPQPLTYLVDDVARRHGQLRVGAAAAYVRCDDDAMLDEILADKRSQTLRLRRLAPTVLAAQADPGTLLDGLRSMGFAPAAESPDGDVMVSRAHERRTPPRTAPEPVPEGPPTPDPTLLAAAVRAVRGGDQAATAPRKPVSEAVRSAGPGELPRTTPSETLATMQAAVMTGETLLIGYVNAEGGATRRVIAPVRVEGGFVTAFDHTAEETRTYQLHRITGVAELADDPA
>NZ_CP045178.1|WP_077973586.1|3650627_3651980_-|hypothetical-protein
MGIESDQLVFDYLSRVGDLAQQRQLPSGTRMRLVTELRGEIDRGRAGAGTPDTPAGVRRILARLGSPDAVVDAAGPGGSAHADSAAPPSPVHAPVPEPGDAGSGGDPGGGRGGRSGSGAGKAGGKVGGLGRGVPGPRKPLKNPLRNALKKPQAPEAGTGRAAGAGAGGAESVPGLSSSAPGAPAPGAPAPDASAPGASGPSADSVFGPGSGSGSGSGSGSGFFFDQEAPDAGSVSLPGQRRGASPPHLAGMEELGSDGSEPDWWRLDSSPFGAGEKVPGFVGGVEIPEILRPPEPTPGPDQQRVVQPVVEAVEVPVPVRRRGLARLRRPAGEAGDAGLGGLSNPLLLLSVALLVVGAVLGNWILLGGGWLIAYASRRLSAAESKWAVFVMPGLVVAGAFVWLWGRQERHWGDPIVQGQMADVLSDTWPWVVRGAAVASAVYVAWRSQKVR
>NZ_CP045178.1|WP_077973588.1|3649254_3650256_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MTRTPGHGRRATLSGALALAGALTLAACSSGPGSGSSPGSGGVGTDAKAGATHTVKTAMGAVQVPGAPKRVVVLDTAELDSVITLGVKPVGATRAGAASDFLGYLPKNQVTGVKNVGEIGNPNLETVAALKPDLILTNKVRDEARYGQLSAIAPTVMTETTGYPWKQNFRVHAEALGRLPEARKAERAYRKQVADVTEAVGGRRKAAATSVNIVRFVEGADIRIYGQKTCIATILGDVGLGRPAITEKAKDGWSYDVSPEKIDLADADVIFHATYGDPRKAKATEVLDSGLWKRLPAVKNHRVTGVDDELWIQGIGYTAAGKILAELESGLTR
>NZ_CP045178.1|WP_077973477.1|3648217_3649012_+|ABC-transporter-ATP-binding-protein
MTARLTTRGLTLAYEERTVVEGLDLDVPDGRVTVIVGPNACGKSTTLRALGRLLKPREGSVLLDGESLATLPTKRIAQRIGLLPQTPVAPDSITVGDLVARGRQPHQHWWQQWSDEDERAVTDAMDRTDVSALADRAVDELSGGQRQRVWIAMALAQETGLLLLDEPTTYLDIAHQVEVLDLVRQLNHDQGRTVVVVLHDLNQAARYADHLVAMKSGEVVAEGAPAEVVTEELVRDVFGLECVVVPDPVTGSPLIVPGAPWSAA
>NZ_CP045178.1|WP_077973463.1|3663711_3663978_-|DUF4031-domain-containing-protein
MTVYIDPPNWPGHGRMWSHLVSDVSYAELHAFADILGVPRRAFDGDHYDIPSHRYADAVAAGAVATGSKELVRRLIGAGLRRRKRRAV
>NZ_CP045178.1|WP_107503034.1|3663974_3664358_-|hypothetical-protein
MPVEPLERTLHAARALVLADLAVGEIADAHVVSMVEESVTQRRWWVEQWPEGAEFVPGLVAQDVKDALLDQHGRWPLCPVCAEGEPHALDVEPELGPDPHWVCHEAGIVVAPVGLLATVPGLGGPAE
>NZ_CP045178.1|WP_107503032.1|3664597_3665695_+|MurR/RpiR-family-transcriptional-regulator
MGRQEGLDAFPGRKYLSFVTEEVKESFISANRSANGGANGSAPRNGTGTGTRSTPRTGSGNGRQNPTRTPPAPAALAAKVRTIAPTMTRSMQRVAEAVAADPAGCAALTVTGLAEHTRTSEATVVRTARLLGYPGYRDLRLALAGLAAHQESGRPPTVTADIAVDDSLADVVAKLAHDERQTLADTAAGLDPVQLGAAVTALAAARRTDIYGVGASGLVAQDLAQKLLRIGMIAHAHSDPHLAVTNAVQLGARDVAVAITHSGATGDVIEPLRVAFDQGTTTIAITGRPDGSVSQYADHILTTSTARESELRPAAMSSRTSQLLVVDCLFVGVAQRTYERAAPALAASYEALAHRHTPRSPQSHR
>NZ_CP045178.1|WP_077973461.1|3665896_3666877_+|N-acetylmuramic-acid-6-phosphate-etherase
MTTTTGANHDGNTSHGNTSHGGLRAQLDTLTTEAFRPELAEIDMLSTEEIARTMNGEDATVPAAVAARVPEIAAAIDATAERMARGGRLVYAGAGSAGRTGVMDASECPPTFNTAPGQVVGLIAGGPSAMVTSVEGAEDSKELAAADLDALGLTSDDVVVGVSASGRTPYAIGAVEHARHTYGALTIGLSCNAGSALAAAADHGIEVVVGPELLTGSTRLKSGTAQKLVLNMISTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGADDDEVEAALTATGGEVKNAILVVLGGVDGATSARLLDESRGGLRAALTAARAE
>NZ_CP045178.1|WP_107503031.1|3666943_3668584_+|PTS-alpha-glucoside-transporter-subunit-IIA
MAENKNRDTAAAILPLVGGAANVTSVVHCMTRLRLGLRDRSLVREEALRALPAVLGVVEDETYQIVLGPGVVARVTPEFEALVAEAWRAAPGRAPEGPAVEGGPADGPASAPAPTPTTPPPPSSPPPPSSPSPPSPPPVIGAEELAGRGAELRAARKARNATPVKLFLRRIADIFVPLIPALIGCGIIAGLNGLLVNLGWLGSVTPALSAVASGFMALIAVFVGYNTAKEFGGTPVLGGAVAAIIVYAGVAEIDVFGQRLAPGQGGVLGALGAAVLASYIERWCRTWVPEAIDVLVTPTLTVLLAGLVTLYGLMFAAGEVASAIGTGANWLLDNTGAFAGLVLGGLFLPLVMLGLHQALIPIHTTLIEQQGYTVLLPILAMAGAGQVGCAMAVYLRLRHNDSIRKTIRSALPAGLLGVGEPLIYGVSLPLGRPFVTACVGGAAGGAFVGLFSMLGDKVGSTAIGPSGWALFPLLKGNQGLGTVAAVYGLGLLLGYVVGFAATYAFGFSREMLAELNAPPRARATDGTTAAPPVPARPEPVAETPTP
>NZ_CP045178.1|WP_143621558.1|3668573_3668945_-|hypothetical-protein
MTGRRVPHPRPIRNPEARGRPAGLAEALLAGAFVLAVLMNLTRSVVEPGGVLWGAARVVVAVLFAAGLVWFAGARARRATQARGPLEARQARQPWEARQAREAWQPRQSRETRSGRSHVRPTA
>NZ_CP045178.1|WP_077973460.1|3669001_3669583_+|hypothetical-protein
MARPFERCYVPDMPSAEEKHPGQPTGQPTGQPAGQPAGQPSDRPEEAIPEEAIPEEATPDGPAPADAIPEDVLTRVGETVVRWAAEWGEDDLRRIAIVATTRDAATRWIMGGRVRSTDERVYLAVVRGTFGRHVEGTDRFTTGAWAALFIDRTSLHVTGMNLRPMDYAPETGPTPLGRVYDLRGADFSDGNGK
>NZ_CP045178.1|WP_143621555.1|3669875_3670139_-|hypothetical-protein
MADALRDRLRGYIQALADPADAYAHRLADNRAKDIALSTVVHARAVAADRGGDPVASLRLLGKSAEILSRYTAAARPLPAPPSGRCP
>NZ_CP045178.1|WP_143621552.1|3670214_3671081_+|helix-turn-helix-domain-containing-protein
MAANTGATFLRIMLGAELIRLRENAGLSGEQAAKAVGCAPSTITNLEKGTTGFRRIGQYAELLTAYGVDFEGQELLLDWYKNAKGDDWWTPNTSVLPSGMPVYLGLESGAQIVSPWCPSVVYGLLQTEEYTRALVETAKAADERTTDFVDSTVEVRANRKKLITEHGSELVCLMDESALRNVVGNGDIMRRQYAEIAELSKLRNVAVRIIPFSAPAYRVTSGGFTVLEFDRRALPGPVVAVSTVSHSMQVVSKPKVVKQFARRFDYLARGARPDHETPALLRKLAREV
>NZ_CP045178.1|WP_077973577.1|3671086_3671305_+|DUF397-domain-containing-protein
MNAHSNNGRPNGQWFKSSYSSEGGTDCVEACPYPGAVHIRDSKQNAEDGARLTFPLAAWTSFTRQVTRHPSA

Crispr_ID: NZ_CP045178_11

• CRISPR_ID: NZ_CP045178_11
• CRISPR_location: 4137389-4137586
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of NZ_CP045178_11

Consensus_repeat	Method
GTCGGGAGCGNNNTCGGN	CRT

spacers of NZ_CP045178_11

>11.1|4137407|30|NZ_CP045178|CRT
AGCGCCGTCGGGAGCGAGACCGTAAGCACT
>11.2|4137455|18|NZ_CP045178|CRT
AGCGAGACCGTAAGCACT
>11.3|4137491|30|NZ_CP045178|CRT
AGCGAGACCGTAAGCACTGTCGGAAGCGCG
>11.4|4137539|30|NZ_CP045178|CRT
AGCACTGTCGGAAGCGCGGGCGCGAACACG

CRISPR arrays and Neighbor proteins around NZ_CP045178_11

CRISPR arrays

The CRISPR arrays of NZ_CP045178_11

>merge|NZ_CP045178|11|4137389-4137586|CRT
GTCGGGAGCGCCGTCGGGAGCGCCGTCGGGAGCGAGACCGTAAGCACTGTCGGGAGCGCCGTCGGGAGCGAGACCGTAAGCACTGTCGGGAGCGCCGTCGGGAGCGAGACCGTAAGCACTGTCGGAAGCGCGGTCGGGAGCGAGATCGTAAGCACTGTCGGAAGCGCGGGCGCGAACACGGTCGGAAGCGAGATCGGA

>NZ_CP045178|11|3|4137389-4137586|CRT
GTCGGGAGCGCCGTCGGG	AGCGCCGTCGGGAGCGAGACCGTAAGCACT
GTCGGGAGCGCCGTCGGG	AGCGAGACCGTAAGCACT
GTCGGGAGCGCCGTCGGG	AGCGAGACCGTAAGCACTGTCGGAAGCGCG
GTCGGGAGCGAGATCGTA	AGCACTGTCGGAAGCGCGGGCGCGAACACG
GTCGGAAGCGAGATCGGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077972496.1|4147078_4148641_+|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	unknown	unknown	gnl|CDD|223704
NZ_CP045178.1|WP_077972499.1|4145610_4146459_+|DUF2662-domain-containing-protein	unknown	unknown	gnl|CDD|378850
NZ_CP045178.1|WP_077972561.1|4128338_4130147_-|2-oxo-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl|CDD|237001
NZ_CP045178.1|WP_077972563.1|4125195_4126122_-|molybdenum-cofactor-guanylyltransferase	unknown	unknown	gnl|CDD|133000
NZ_CP045178.1|WP_077972508.1|4141026_4141878_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077972550.1|4144067_4144727_+|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl|CDD|224103
NZ_CP045178.1|WP_077972512.1|4136238_4137159_-|RNA-methyltransferase	unknown	unknown	gnl|CDD|223640
NZ_CP045178.1|WP_077972498.1|4146469_4147003_+|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|238017
NZ_CP045178.1|WP_077972514.1|4134376_4136095_+|phenylacetic-acid-degradation-protein-PaaN	unknown	unknown	gnl|CDD|131341
NZ_CP045178.1|WP_077972520.1|4126455_4128018_+|trypsin-like-serine-protease	unknown	unknown	gnl|CDD|214473
NZ_CP045178.1|WP_077972510.1|4140354_4140699_-|rhodanese-like-domain-containing-protein	unknown	unknown	gnl|CDD|238089
NZ_CP045178.1|WP_077972504.1|4143542_4143938_-|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl|CDD|224647
NZ_CP045178.1|WP_107503003.1|4131171_4132497_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl|CDD|213783
NZ_CP045178.1|WP_077972518.1|4130146_4131175_-|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl|CDD|223101
NZ_CP045178.1|WP_077972506.1|4141917_4143375_-|DUF2252-domain-containing-protein	unknown	unknown	gnl|CDD|313268
NZ_CP045178.1|WP_077972492.1|4150085_4151543_+|penicillin-binding-protein-2	unknown	unknown	gnl|CDD|223839
NZ_CP045178.1|WP_077972565.1|4123234_4124869_-|molybdopterin-molybdotransferase-MoeA	unknown	unknown	gnl|CDD|238452
NZ_CP045178.1|WP_107503005.1|4133427_4134024_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380061
NZ_CP045178.1|WP_107503002.1|4132668_4133181_+|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
NZ_CP045178.1|WP_077972494.1|4148667_4150089_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|223843

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077972496.1|4147078_4148641_+|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase	gnl|CDD|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	7.08148e-79
NZ_CP045178.1|WP_077972499.1|4145610_4146459_+|DUF2662-domain-containing-protein	gnl|CDD|378850	pfam12401, DUF3662, Protein of unknown function (DUF2662). This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with pfam00498.	8.55539e-55
NZ_CP045178.1|WP_077972561.1|4128338_4130147_-|2-oxo-acid-dehydrogenase-subunit-E2	gnl|CDD|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	1.54181e-108
NZ_CP045178.1|WP_077972563.1|4125195_4126122_-|molybdenum-cofactor-guanylyltransferase	gnl|CDD|133000	cd02503, MobA, MobA catalyzes the formation of molybdopterin guanine dinucleotide. The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.	8.0903e-30
NZ_CP045178.1|WP_077972550.1|4144067_4144727_+|FMN-dependent-NADH-azoreductase	gnl|CDD|224103	COG1182, AcpD, Acyl carrier protein phosphodiesterase [Lipid metabolism].	9.60168e-46
NZ_CP045178.1|WP_077972512.1|4136238_4137159_-|RNA-methyltransferase	gnl|CDD|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	4.57902e-37
NZ_CP045178.1|WP_077972498.1|4146469_4147003_+|FHA-domain-containing-protein	gnl|CDD|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	1.64418e-18
NZ_CP045178.1|WP_077972514.1|4134376_4136095_+|phenylacetic-acid-degradation-protein-PaaN	gnl|CDD|131341	TIGR02288, putative_ring-opening_enzyme, phenylacetic acid degradation protein paaN. This enzyme is proposed to act in the ring-opening step of phenylacetic acid degradation which follows ligation of the acid with coenzyme A (by PaaF) and hydroxylation by a multicomponent non-heme iron hydroxylase complex (PaaGHIJK). Gene symbols have been standardized in. This enzyme is related to aldehyde dehydrogenases and has a domain which is a member of the pfam00171 family. This family includes sequences from Burkholderia, Bordetella, Streptomyces. Other PaaN enzymes are represented by a separate model, TIGR02278.	0
NZ_CP045178.1|WP_077972520.1|4126455_4128018_+|trypsin-like-serine-protease	gnl|CDD|214473	smart00020, Tryp_SPc, Trypsin-like serine protease. Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.	5.1887e-35
NZ_CP045178.1|WP_077972510.1|4140354_4140699_-|rhodanese-like-domain-containing-protein	gnl|CDD|238089	cd00158, RHOD, Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.	6.66351e-26
NZ_CP045178.1|WP_077972504.1|4143542_4143938_-|helix-turn-helix-transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	2.48829e-31
NZ_CP045178.1|WP_107503003.1|4131171_4132497_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl|CDD|213783	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	5.04806e-159
NZ_CP045178.1|WP_077972518.1|4130146_4131175_-|alpha-ketoacid-dehydrogenase-subunit-beta	gnl|CDD|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	3.16995e-151
NZ_CP045178.1|WP_077972506.1|4141917_4143375_-|DUF2252-domain-containing-protein	gnl|CDD|313268	pfam10009, DUF2252, Uncharacterized protein conserved in bacteria (DUF2252). This domain, found in various hypothetical bacterial proteins, has no known function.	1.14904e-165
NZ_CP045178.1|WP_077972492.1|4150085_4151543_+|penicillin-binding-protein-2	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	2.67064e-84
NZ_CP045178.1|WP_077972565.1|4123234_4124869_-|molybdopterin-molybdotransferase-MoeA	gnl|CDD|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	2.31795e-95
NZ_CP045178.1|WP_107503005.1|4133427_4134024_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	3.42549e-19
NZ_CP045178.1|WP_107503002.1|4132668_4133181_+|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.23223e-30
NZ_CP045178.1|WP_077972494.1|4148667_4150089_+|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	5.71535e-79

Protein sequences

>NZ_CP045178.1|WP_077972512.1|4136238_4137159_-|RNA-methyltransferase
MNVDETGATASGAGSATPDGAWQAAVGLWRGRTGEPGAVLLDGFHAIKHAVRFGARIPVAVTADRTAVLALAAELAPDVVPSLADLLTEVPAAVLRELVPRAHPTGVAALADRPDRQAALKTLRRAPRTAPVVVLDNPRNLGNAGAVIRLAAGFGATGVVTTGTLDPWHPTVVRGGAGLHFATCVEQLAVDELPPGPVYALDPEGADIRGLTLPDEALLAFGSERHGISDALRDRADALVSLPMRPQVSSYNLATSVGMALFHWSSGTAAGIETATGIETATGIETGAGTATATGTGSGAGGRSGR
>NZ_CP045178.1|WP_077972514.1|4134376_4136095_+|phenylacetic-acid-degradation-protein-PaaN
MAAELTVPHLVGKYRPVLDQALESIRTRAYWSPHPEHPKAYGENGTLSAAEGKAAFDAVLGSRLDLGQPGTDDWCGAETSPYGPELGVTYPHVDPDVLLPAMRAAMTAWRDAGPETRAVVCLEILARISARTHEFAHAVMHTSGQAFMMAFQAGGPHAQDRGLEAVAHAFAEQDRTPASAPWSKPQGKRDPLTLEKSFTPVPRGIALLIGCNTFPTWNGYPGLFASLATGNAVLVKPHPRAVLPLALTVQVAREVLTEAGFSPDLVALAAEREGEGIAKELAPRPEIRIIDYTGSTAFGTWLETNAHQAQVYTEKAGVNTVVIDSTDDYKGMLANLAFSLSLYSGQMCTTPQNLLIPRDGISTDAGAKSFDEVVTDLSAAVTGLLSDDTRAAGLLGALVNPGVKGRLDAAPEYGEVALASRTVDLPEFPGATVRTPAVVKQDAAKPVTGQDGEPAYLSECFGPVSFAVAVDSSAHAVDLLRRTIREKGAMTVAAYTTSPEVEKAVEEACFDECAQLSLNLTGGVYVNQTAAFSDFHGSGGNPAANSALTDGAFVANRFRVIEVRREAAAGTA
>NZ_CP045178.1|WP_107503005.1|4133427_4134024_-|TetR/AcrR-family-transcriptional-regulator
MAAAKRDTYTPETLLSVAVRVFNDRGYDGTSMEHLSKAAGISKSSIYHHVSGKEELLRRAVSRALDGLFGILGEERAREGRAVERLEYVTRRTVELLMAELPYVTLLLRVRGNTDTERWAMERRRDFDHQVAELLKAAVAEGDLRTDVEIRLATRLLFGMINSVVEWYRPEGRGAVDNQEVSDAVVRLAFDGLRRQRG
>NZ_CP045178.1|WP_107503002.1|4132668_4133181_+|Lrp/AsnC-family-transcriptional-regulator
MGPERMADAADPRPLDAIDKDILRILQSDGRASIRSVAEAVHVSRANAYARINRLIDDGVIRGFGARVNHERAGQGASAYITLKIVQNSWRTVRDQLRALPGASHIALVSGDFDVLLLVHSPDNRALRELVLTRLQAIPEVLSTRTLLVFEEEDPQPQPGGTRGTGGGTD
>NZ_CP045178.1|WP_107503003.1|4131171_4132497_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MTVMDERGAYRPAPPPAWRPATDPGPLLPDDEPYRVLGTPAQEEAEEKLLLRLYAELVRGRRFNTQATALTRQGRLAVYPSSTGQEACEVAAALVLREQDWLFPTYRDTLALVARGVDPVEALTLLRGDRHTGYDSRAHRVAPLCTPLATHLPHAVGLAHAARLKGDDVVALALVGDGGTSEGDFHEALNFAAVWRAPVVFLVQNNGFAISVPLAKQTAAPSLAHKAVGYGIPGRLVDGNDAVAVHEVLSQAVRRASEGGGPTVVEAVTYRLDAHTNADDATRYRKDEEIEAWRGHDPVALMERALTARGLLDEAGVEAERDRAERFAAGLRERMNTDPELRPLDLFGHVYADRTTQLMEQAAMLGAELEAETEPSAGSETGPSAGSETGPSAGSERGPSAGVQTEPAVGAGPTGRGGSGGQDSSVRTVSGASGRGGGETR
>NZ_CP045178.1|WP_077972518.1|4130146_4131175_-|alpha-ketoacid-dehydrogenase-subunit-beta
MTTVTAGPASAAGAKPATMAQALGRAMRDAMAEDPAVHVMGEDVGTLGGVFRVTDGLAAEFGDDRCTDTPLAEAGILGAAVGMAMYGLRPVVEMQFDAFAYPAFEQLISHVAKMRNRTGGALPLPLTIRVPYGGGIGGVEHHSDSSEIYYMATPGLHVVTPATVPDAYGLLRAAIASDDPVVFLEPKRLYWSKAPWSPQDPEAVPPVGRAVVRRPGRSATLITYGPSVPVCLEAAEAARAEGWDLEVVDLRSLVPFDDETVCASVRRTGRAVVVHESGGFAGPGGEIVARVTERCFHHLEAPVLRVSGFDIPYPPPMLERSHLPGVDRVLDAVARLQWEAAN
>NZ_CP045178.1|WP_077972561.1|4128338_4130147_-|2-oxo-acid-dehydrogenase-subunit-E2
MARVHEFKLPDLGEGLTEAEVVRWLVEVGDIVETDQPVVEVETAKAMVEVPCPYAGVVTARFGEEGKELPVGAPLLTVAVGSAADGNGADGGGSEGNGSEGISSEGSGVDGIGAEGMGPDGGGAAGVGGDEPGVVGELDGRSAAPEVTSGEAAADSSGNVLVGYGTGAAPARRRRVRQGPLIGGAFGGGASAGGGASHGEPKTRGHAGSGPYEASGAHEASGAHEASGAHEANGVRMAGGSRASEGARVASGARAGEGVRSGRPLDGPVPVISPLVRRLARHNGVELRDVTGTGPEGLILRGDVESAMRTRAVRTTEDARYGADGDGRAAVPAHDAEEQRAQTNNGVGVGVGAGAGAAFDQRRETVAGSYAESEGTRVPLRGMLGAAADRLSRSRREIPDATCWVDADATELTLARSAMNAAGGPKVSLLALLARITVAALVRFPELNSRVDMEAREIVRLDAVHLGFAAQTPRGLVVPVVRDARGRDVESLTAEFARLTEAGREGRLAPAQLTGSTFTLNNYGVFGVDGSTPIINHPEAAMLGVGRITAKPWVHDGELAVRQVVQLSLTFDHRVCDGGTAGGFLRYVADCVEQPAVLLRSV
>NZ_CP045178.1|WP_077972520.1|4126455_4128018_+|trypsin-like-serine-protease
MRNRSLLFCVMLAVAAPLLGAAPAQAIVGGTESEQAYSFMGSFQPSYPAPPRPDKHGCGVEVLAPQWVLTAGHCAGRNPTGAKTGVPRGWKVRVGSLDTTSGGEVAEVDHYYRLATNNDEGGFWGKDLSLLHLRTPVKTKPVRIASTTPRDNAPVRIMGWGTTCADSNDPACLPTRLREADTVVQPTSVCEKASPGELCVGSRDGSVAAANMDSGGPALVREDGEWALAGTVSGPDGDNAPTLYTDVTKHADWINGIITGTDVPPDDHVPNVEGAVDLGVCAGSVVRAPASRPKDPALLLTNGHCVEGEQPAPGAALVDRPADREVPIADRQGYPRATAHANRLLYATMTGTDIALYRLDKSYARLKAEGAKVFQLTSTPVRAGAPLTMAYTSERLNCTAQAVVAHVREGRYQQDESIRYATEAECAPWPGTSGSALLAADGNTVVGIHNTHNQAGEQCTDNNPCEVDRAGDVTSVQGRGYGQQVNMVPACLAKGSKLDLSHKGCTLALTGATTRSAEGR
>NZ_CP045178.1|WP_077972563.1|4125195_4126122_-|molybdenum-cofactor-guanylyltransferase
MDRPVVHTQGVSAYDAVVLAGGAAKRLGGADKPGVRVGGRSLLDRVLAACSGARTTVVVAAPRPTARPVIWAAEEPRGGGPLAALDAGLRRTGQEQVLALSADLPFLDAATVERILSALAESTSDGVLLTDGDGRDQPLVAAYRSAALRRELGRLADDHGALTGLPLRHLTARLKLVRLADDVASFDCDTWQDIATARARIREHGHVLDQWISAVKEELGIDLDVDTGVLLDLARDAAHGVARPAAPLTTFLVGYAAARAEGGPEAVAAAANRAAALAGRWAQEQDPAASGDTPAATGDTPGTAPGTE
>NZ_CP045178.1|WP_077972565.1|4123234_4124869_-|molybdopterin-molybdotransferase-MoeA
MNLGAGDAGVRPDAAAKPGRDNDATGAPGPRAHDSGAPEGPTPDDRRGDRRPGPSRTPRTSQTSDEPPAPGAQGAPGAPGTQGAQGVSATPDDPAGHQSEKTRPEKTRPEKGQPEKTRPEKTVPETTDPEKTDSEKPRPETTHRAVPWDEARDIADLAARRVVARTASVRTPPPRPLESTLGLVLAAPLTALTDLPPFDTSAMDGWAVAGPGPWAVRDGGGVLAGQTKPLPLADGEAVRIATGARIPAEATAVIRSEHGLADDNGRLHARRDVVQGQEIRLRGQECRSGDQLLSDGALVTPAVLGLAAAAGYDTLAVFPRPTAEILVLGDELLTSGLPEDGLIRDALGPMLPPWLRALGAEVTAVRRLGDDAELLHRAITESEADLIVTTGGTAAGPLDHVHPVLRRIGAELLVDGVAVRPGHPMLLAAVAPGQHLVGLPGNPLAAVSGLLTLAEPLLRRLAGRAPAEPYRAVVREGTHGHPYDTRLVPVTFRADEAEVLRYNGPAMLRGIAVAEGLAVVPRGGAPAGRALEILDLPWIGGGFT
>NZ_CP045178.1|WP_077972510.1|4140354_4140699_-|rhodanese-like-domain-containing-protein
MHSGSVPTTAVSELSDEDFLLDVREDDEWQAGHAEGALHIPMSDFVSRVGELTEAAPQDGKVNVICRSGGRSAQVTMFLVQQGVDAVNVDGGMQAWEAAGRPIVDEKGGAGFVA
>NZ_CP045178.1|WP_077972508.1|4141026_4141878_-|hypothetical-protein
MTTPEAEPTQSRPEDRLEKAVRAAEQALIEYEIAVETFRVEVENFSRLHHQKLGPMYARLDELDAGIAEARAALTGDPEDARLAQEARARVMPMPGVEELFHGWMDSDGLFPEAAAMLTDQSVRPPQRVRPSDEARRLYRDLVRKAHPDLAQEDKERDRRDEFISRVNNAYGRGDEALLRELSAEWEAGPAPEEQQPTKSEELYVRLEWLAQRKELLAMVAKDLEESAIGSMLRMAPDDPDRLLDEIAEQLLTTVSEREHELAELVAQVPGSTSSQAPGTAAE
>NZ_CP045178.1|WP_077972506.1|4141917_4143375_-|DUF2252-domain-containing-protein
MTGAEGKSTGTRGRATVSATPGRRARRLPVVPGFAGWPSEGSPKKAGKALRAQIPRAAHAEYTLDAGRPDALRAVEESNRGRLQELAPIRVGRMAASPFAFLRGSAGLMAYDLAKTPASGTGAQICGDAHAGNFGLYADARGGLIIDLNDFDETAWGPWEWDVKRLAVSLVLAGREAGAGEADCAEAARDAVGAYRRTMRLLSRMPVSEAWNAIADERLVSHADARDLLGTLEKVSEKARRNTGARFAARSTRELPGGGRRFVDAPPVLRRVPDAEAAAVAAALGEYLRSLPEDRLPLLARYAVHDIAFRVVGTGSVGTRSYVALLLDHRGEALVLQVKEARPSVLVPHLGRAGFPAADVPHEGRRVVLGQKRMQVVSDTLLGWTTVDGLPFQVRQFRNRKGSVDPAELATGQLDDYGRMTGALLARAHAHSADPRVIAGYCGKSDVLDRAVAEFAVACADRTEADHEQLSKAVARGRIAAETGV
>NZ_CP045178.1|WP_077972504.1|4143542_4143938_-|helix-turn-helix-transcriptional-regulator
MAGTGDESEQACSSVDISITRVFALLGKRWTGPIVSVLLQRPVHFADLRRAVPGISERMLSDRLTELGGAGLVVREVNEGPPLRVAYRLTPAGAELRPALDELAKWADKHLVGDNVCTESMRGEEPLRTEA
>NZ_CP045178.1|WP_077972550.1|4144067_4144727_+|FMN-dependent-NADH-azoreductase
MATLLHIDSALAPQGSASREITALFVKSWQEAHPEGVVVYRDLNADPVPHLDIHGFTSSFTDPSEQTAEQKARAAVRDELASELENADAVLIGAPMYNFTIPSTLKAWLDQVIIVGRTGGENGTIAGKPVTVVASRGGSYAPGTPRESFEFVQNYLDKVFTGMLGAEVDFIVPELTLAKTNPAMADLIPLAEAASTKAREDADTKARALAARLTSKTAA
>NZ_CP045178.1|WP_077972499.1|4145610_4146459_+|DUF2662-domain-containing-protein
MGVMKRFEQRLEGLVNGTFAKVFKSEVQPVEIAGALQRECDNNATIWNRERTVVPNDFIVELSTPDFERLSPYSGQLGDELSGMVTDYAKQQRYTFMGPVKVHLEKADDLDTGLYRVRSRTLASSTSQGPDQAPPRANGQNAGGGYGYPQAPSGPPPMPAGPPPGRPGGGHAAPPQRPQQGPSAGQSGSRTKHWIEINNNRHQITRPTLVLGRSTEADVRIDDPGVSRRHCEIRTGTPSTIQDLGSTNGIVVDGQHTTRATLRDGSRIVVGKTTIIFRQAEG
>NZ_CP045178.1|WP_077972498.1|4146469_4147003_+|FHA-domain-containing-protein
MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTQRGSRRDNGASAARAQQNSGRGTPPPQRQQGGRQQGGRQRRGAPTKLVVSEGTLTGTTVALQGQTISLGRAHDSTIVLDDDYASSRHARIYPDRDGQWIVEDLGSTNGTYLDRTRLTTATPVPLGAPIRIGKTVIELRK
>NZ_CP045178.1|WP_077972496.1|4147078_4148641_+|Stp1/IreP-family-PP2C-type-Ser/Thr-phosphatase
MGSVARQDRLYPEPTGEVRMSLSLRFAAGSHKGMIREGNEDSGYAGPRLLAIADGMGGQAAGEVASSEVISTLVDLDDEIPGSDILTSLGAAVQRANDQLRVMVEEDPQLEGMGTTLTALLWTGQRLGLVHVGDSRAYLLRDGVLTQITQDHTWVQRLVDEGRITEEEATTHPQRSLLMRALGSGDHVEPDLSIREVRAGDRYLICSDGLSGVVSHQTMEETLASYQGPQETVQDLIQLALRGGGPDNITVIIADVLDVDSGDTLAGALNDTPVVVGAVAENQHQAHDEGAMQTPAGRASGLGRPASPQDHGGGGFGPPGGATPAYAPEGGSFDSYSEDDFVKRGGRRWLKRSLWTVVVLAVIAGGLYGGYRWTQTQYYVGSEGSHVALYRGISQDLGWVNLSKVDSHHRDIELKYLPPYQRKQVESTITEGDRDSARKKIDELKVQASACEKDSQRRAAAEKQKDAEKDKNARTGEDQAGGTGQSATEPTKSSKNAPTPTPGPSLSEDEQKLVPLCGKQ
>NZ_CP045178.1|WP_077972494.1|4148667_4150089_+|FtsW/RodA/SpoVE-family-cell-cycle-protein
MSSSNTHTSTIGAIGAPSRRNTELALLVFAVVIPVFAYANVGLSIGGELPSGMLGYGLGLGLLAGVAHLVVRKFARYADPLLLPLATLLNGLGLVLIWRLDQSPRLKQRAESAFGSYSPDAPKQLLYSAIAIAMFVGVLMLLKDHRILQRYTYISMAVALVLLIIPMFFPAVNGAKIWINLGGFTIQPGEFAKIIIAIFFSGYLMVKRDALALASRRFMGIYLPRGRDLGPIITIWALSLLILVFETDLGTSLLFFGMFVVMLYVATERTSWIVFGLVMSAAGAVGVATFEPHVQSRVTAWLDPFDCYQSDVTGACQQIADGLMSFGAGGTLGAGLGQGNSDLIGFAANADFILTTVGEELGLAGMMAMLLLYGLIVERGLRTALAARDPFGKLLAAGLSGAFAIQVFVVAGGVLGLIPLTGMTMPFLAYGGSSVLANWVLIAILIRISDTARRPAPAPAPTSDAEMTQVVRP
>NZ_CP045178.1|WP_077972492.1|4150085_4151543_+|penicillin-binding-protein-2
MNKPLRRIAIFCGLLVLALLVRTNWIQYVQADSLQTDEKNQRIRIERYSEPRGNIIVDGDPITGSKKTDDPYLTYKRTYKDGPMWAPVTGFASQIYGATQIEQLEDKILTGNDDRLFFRNTMDMVTGKKKQGGNVVTTLNAAAQKAAFKGLGDNKGAVAALDPSTGAILALASAPSYDPAKIAGQSKADATEWKKLLDDPDKASVNRALRETYPPGSTFKVVTAAAAMEHGLYDDPDGKTDSPLPYTLPNTSQDLPNEGNLPCKDASLRVALQYSCNTVFGKIGADLGRDKMLETAGKFGFNKPVDTPVRAYPSVFPKKMDKPQTALSSIGQFETAATPLQMAMVASAVANNGTLMEPYMVQQLQAPNLDTIEKHEPKKMSEPLSEENAQKLQSMMETVVNKGTGTSARIPGVTVGGKTGTAQHGVDNSEKPYAWFVSYAKTDEGSPVAVAVVVEDSKAARQDISGGGLAAPIAKSVMQAVLDKK

Crispr_ID: NZ_CP045178_12

• CRISPR_ID: NZ_CP045178_12
• CRISPR_location: 4278190-4278281
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_12

Consensus_repeat	Method
CGGCTCCATGTTTCACGTGAAACAT	CRISPRCasFinder

spacers of NZ_CP045178_12

>12.1|4278215|42|NZ_CP045178|CRISPRCasFinder
GGAGCCGTCGTGGTGGCGATGTGTGGTGCGCGGGCGGTCGTC

CRISPR arrays and Neighbor proteins around NZ_CP045178_12

CRISPR arrays

The CRISPR arrays of NZ_CP045178_12

>merge|NZ_CP045178|12|4278190-4278281|CRISPRCasFinder
CGGCTCCATGTTTCACGTGAAACATGGAGCCGTCGTGGTGGCGATGTGTGGTGCGCGGGCGGTCGTCCGGCTCCATGTTCCACGTGAAACAT

>NZ_CP045178|12|9|4278190-4278281|CRISPRCasFinder
CGGCTCCATGTTTCACGTGAAACAT	GGAGCCGTCGTGGTGGCGATGTGTGGTGCGCGGGCGGTCGTC
CGGCTCCATGTTCCACGTGAAACAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077968489.1|4281809_4284488_+|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815
NZ_CP045178.1|WP_077968497.1|4274145_4276524_-|hypothetical-protein	unknown	unknown	gnl|CDD|369035
NZ_CP045178.1|WP_077968485.1|4286455_4287487_-|alanine-racemase	unknown	unknown	gnl|CDD|143481
NZ_CP045178.1|WP_059143728.1|4289438_4289729_+|30S-ribosomal-protein-S6	unknown	unknown	gnl|CDD|179034
NZ_CP045178.1|WP_077968499.1|4271888_4274099_-|murein-biosynthesis-integral-membrane-protein-MurJ	unknown	unknown	gnl|CDD|273763
NZ_CP045178.1|WP_077968511.1|4266908_4267883_-|thioredoxin-disulfide-reductase	unknown	unknown	gnl|CDD|273540
NZ_CP045178.1|WP_077968483.1|4287558_4288680_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	unknown	unknown	gnl|CDD|367067
NZ_CP045178.1|WP_077968515.1|4264366_4265485_+|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl|CDD|275105
NZ_CP045178.1|WP_077968492.1|4279624_4280707_-|inositol-3-phosphate-synthase	unknown	unknown	gnl|CDD|132491
NZ_CP045178.1|WP_077968510.1|4268054_4269239_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_003949403.1|4290453_4290690_+|30S-ribosomal-protein-S18	unknown	unknown	gnl|CDD|178997
NZ_CP045178.1|WP_077968487.1|4284741_4286280_+|DUF2029-domain-containing-protein	unknown	unknown	gnl|CDD|227937
NZ_CP045178.1|WP_077968514.1|4265812_4266430_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP045178.1|WP_077968478.1|4289801_4290410_+|single-stranded-DNA-binding-protein	unknown	unknown	gnl|CDD|236092
NZ_CP045178.1|WP_077968507.1|4270054_4271779_-|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270875
NZ_CP045178.1|WP_077968509.1|4269235_4270027_-|RNA-polymerase-sigma-factor-SigM	unknown	unknown	gnl|CDD|236604
NZ_CP045178.1|WP_077968490.1|4280762_4281443_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
NZ_CP045178.1|WP_077968513.1|4266515_4266863_-|thioredoxin	unknown	unknown	gnl|CDD|200072
NZ_CP045178.1|WP_077968495.1|4276718_4278167_+|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl|CDD|131739
NZ_CP045178.1|WP_077968481.1|4288856_4289171_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077968489.1|4281809_4284488_+|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	2.59002e-135
NZ_CP045178.1|WP_077968497.1|4274145_4276524_-|hypothetical-protein	gnl|CDD|369035	pfam06682, SARAF, SOCE-associated regulatory factor of calcium homoeostasis. SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.	0.00653889
NZ_CP045178.1|WP_077968485.1|4286455_4287487_-|alanine-racemase	gnl|CDD|143481	cd00430, PLPDE_III_AR, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase. This family includes predominantly bacterial alanine racemases (AR), some serine racemases (SerRac), and putative bifunctional enzymes containing N-terminal UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase (murF) and C-terminal AR domains. These proteins are fold type III PLP-dependent enzymes that play essential roles in peptidoglycan biosynthesis. AR catalyzes the interconversion between L- and D-alanine, which is an essential component of the peptidoglycan layer of bacterial cell walls. SerRac converts L-serine into its D-enantiomer (D-serine) for peptidoglycan synthesis. murF catalyzes the addition of D-Ala-D-Ala to UDPMurNAc-tripeptide, the final step in the synthesis of the cytoplasmic precursor of bacterial cell wall peptidoglycan. Members of this family contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain. They exist as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. AR and other members of this family require dimer formation and the presence of the PLP cofactor for catalytic activity. Fungal ARs and eukaryotic serine racemases, which are fold types I and II PLP-dependent enzymes respectively, are excluded from this family.	5.35528e-08
NZ_CP045178.1|WP_059143728.1|4289438_4289729_+|30S-ribosomal-protein-S6	gnl|CDD|179034	PRK00453, rpsF, 30S ribosomal protein S6; Reviewed.	2.9086e-39
NZ_CP045178.1|WP_077968499.1|4271888_4274099_-|murein-biosynthesis-integral-membrane-protein-MurJ	gnl|CDD|273763	TIGR01695, Putative_lipid_II_flippase_MurJ, murein biosynthesis integral membrane protein MurJ. This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	1.84915e-136
NZ_CP045178.1|WP_077968511.1|4266908_4267883_-|thioredoxin-disulfide-reductase	gnl|CDD|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.15572e-154
NZ_CP045178.1|WP_077968483.1|4287558_4288680_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein	gnl|CDD|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	3.17757e-28
NZ_CP045178.1|WP_077968515.1|4264366_4265485_+|ParB/RepB/Spo0J-family-partition-protein	gnl|CDD|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	3.69186e-72
NZ_CP045178.1|WP_077968492.1|4279624_4280707_-|inositol-3-phosphate-synthase	gnl|CDD|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NZ_CP045178.1|WP_077968490.1|4280762_4281443_-|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	4.07631e-17
NZ_CP045178.1|WP_003949403.1|4290453_4290690_+|30S-ribosomal-protein-S18	gnl|CDD|178997	PRK00391, rpsR, 30S ribosomal protein S18; Reviewed.	9.24137e-38
NZ_CP045178.1|WP_077968514.1|4265812_4266430_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.65322e-05
NZ_CP045178.1|WP_077968478.1|4289801_4290410_+|single-stranded-DNA-binding-protein	gnl|CDD|236092	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional.	5.51801e-86
NZ_CP045178.1|WP_077968507.1|4270054_4271779_-|serine/threonine-protein-kinase	gnl|CDD|270875	cd13973, PK_MviN-like, Pseudokinase domain of the peptidoglycan biosynthetic protein MviN. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This family is composed of the mycobacterial protein MviN and similar proteins. MviN is an integral membrane protein that is essential for growth and is required for cell wall integrity and peptidogylcan (PG) biosynthesis. It comprises of 14 predicted transmembrane (TM) helices at the N-terminus, followed by an intracellular pseudokinase domain linked through a single TM helix to a carbohydrate binding extracellular domain. Phosphorylation of the MviN pseudokinase domain by the PG-sensitive serine/threonine protein kinase PknB recruits a forkhead associated (FHA) domain protein FhaA, which modulates local PG synthesis at cell poles and the septum. The MviN pseudokinase forms a canonical receptor kinase dimer.	2.49981e-58
NZ_CP045178.1|WP_077968509.1|4269235_4270027_-|RNA-polymerase-sigma-factor-SigM	gnl|CDD|236604	PRK09643, PRK09643, RNA polymerase sigma factor SigM; Reviewed.	2.86536e-90
NZ_CP045178.1|WP_077968487.1|4284741_4286280_+|DUF2029-domain-containing-protein	gnl|CDD|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	4.86037e-42
NZ_CP045178.1|WP_077968513.1|4266515_4266863_-|thioredoxin	gnl|CDD|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	1.9329e-46
NZ_CP045178.1|WP_077968495.1|4276718_4278167_+|CCA-tRNA-nucleotidyltransferase	gnl|CDD|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0

Protein sequences

>NZ_CP045178.1|WP_077968495.1|4276718_4278167_+|CCA-tRNA-nucleotidyltransferase
MPNANDDNPSALSQVQHRAVSELLRVSPVADDLARRFEEAGFSLALVGGSVRDALLGRLGNDLDFTTDALPQDVLALVKPWADAVWEVGIAFGTVGCQKNGYQIEVTTYRSESYDRTSRKPEVAYGDSIEEDLVRRDFTVNAMAVALPRKEFIDPHGGLDDLAERVLRTPGTPEESFSDDPLRMLRAARFAAQLDFEVAPDVVAAMTGMAGRIEIVSAERVRGELDKLLLSANPRKGLTLLVETGLADHILPELPALRLESDEHHRHKDVYEHSLTVLEQAIALEDDGPDLILRIAALLHDIGKPRTRRFEKDGGVSFHHHEVVGAKMTKKRMTALKYSNEMVKDVSRLVELHLRFHGYGTGEWTDSAVRRYVRDAGPLLSRLHKLTRSDCTTRNKRKAGALSRAYDGLEERIARLQEKETLDAIRPDLDGNQIMEVLGVGPGPVIGRAYQFLLELRLENGPLDPDAAAEALKTWWAEHSQD
>NZ_CP045178.1|WP_077968497.1|4274145_4276524_-|hypothetical-protein
MAEAAQFPGTRPSPARRWLRRAAALTAGVPLLAGLVQLPAAHASTGSVKAATSDVTGSRTVDVSVDSLTPAAPVPGDTLTVSGSVTNKSKKQVTDAHVALRVGPMLSGRSAIDNAAHRSGYTPGADGTEVGGKYTEKFAKLAPGITQKFSMTIPVKQLQLGSDGVYQIGVSLAGRTTAAPWQEQVLGIKRTFLPWQSEPTARQTRTSYLWPLISTTHLTAENASDEQQTPLFENDSLAQEITPGGRLERLVTLGKDLDITWVVDPDLLASVDAMTGSYNVQNAKGKPTPGRNQDVAKQFLKSLTEAVKGKKIVTLPFADPDLASIAQNGRNVSGSLSNLKDATQVAPVTVQTILHVRPSTDFAWPVEGAIDPSIVDVATSAGARKVIAGSDSVQESASLPYTPSAARPIGGGTTAVVSDSRLSNAFKGDMTRAENSTLAVQAFLAQSLMITRQDEERQRSIVVAPQRMPTASQAETMATALHALDDERWSLPQSLDSAADTKPDPDAATRVPGAGSYPAALRKQALPHAAFEAIRGTQEKLDGFKAVLDAPKRVVTPFGRAMERETSTSWRGRPVEADRYRQSVTSYLNELTRQVQLIEKTEAKLSGRSATIPVTVQNNLFQGVRHLRLRLTSTNPTRLKIGDGPYSEQPVKISSGHSQSVKFTTNANANGPVTVKAQLYTEDGQAYGSPILFDVKVTEVTITVMFVIAGGVLLLVLAGLRMYTQRKRAASRGPGDGGTDDGEGAGPGPGPRPDGEAGPGPAPDGPKQPSDPAPDTEPESTEASGTGERVDR
>NZ_CP045178.1|WP_077968499.1|4271888_4274099_-|murein-biosynthesis-integral-membrane-protein-MurJ
MNAPYDGDRGQGAGDPAQGGDAPPGPPYSGQPPHHQGQPPQPPAPDAYLQDAYDQDPYRSQDLSAQDPVTEALYDRSAHPPPPPGTYQETQPLYAPPAASQYPPDPRIWAQTPPPEPDGPSRHLPYADDPRTVQFVGVDDLVTHSGEERREPDAFAHLFKDQQAGGGPQAAAGVLAPTPEPQQAPVPPKSSSRAAGLLKSSALMAAGTIVSRLTGFLRTLVIAAAIGVGTLNDTYQVANTLPTMIYVLVGGGALNAVFIPQLVRAMKSDDDGGEAYANRLLTLVVTLMAAVTTICVLCAPFLIWMMSPKIASDPQRLDVAVAFARYCLPTMFFMGVHIVLGQILNARGRFGAMMWTPVLNNIVIIATFGAFIWVFGGYTDSGVSASNVTPEGVRLLGIGTLLGLVVQALAMVPYLRDAGFRMRLRFDWRGHGLGKALGLAKWTFFFVLANQLGMIIVTQLATWAGSVAEKQGHTGTGITAYNYALLLWQMPQAIITVSVMTAVLPRISRSAVDGDAAAVRDDISYGLRTSAVAIVPCAFAFLALGVPMTTLLYAGSGEAGARSIGYILMAFGLGLIPYSVQYVVLRGFYAYEDTRTPFYNTVIVAAVNAAASGLSFVLLPAQWAVVGMAASYGLAYVFGVGVAWRRLRKLLGGDLDGAHVLRTYARLIGASVPAALVGGGVAFALTRALGSGAGGSLVALVVGGIVLLGVFYVAARRMRVAELNSMIGMVRGRLGR
>NZ_CP045178.1|WP_077968507.1|4270054_4271779_-|serine/threonine-protein-kinase
MADRSTSAVDVAQDSGGEPLTAKAEEATADEVTEPLEGVPAHDGAQEDDGVQDPVTAASPELHSGHKLAGRYRLEECVTRLDGFSSWRAMDEKLRRAVGVHLLPADHPRARSVLAAARSAALLGDPRFVQVLDAVEENDLVYVVHEWLPDATELTALLAAGPLEAHDAYQLVSQISQAMAAAHREGLAHLRLTPGAVLRSSSGQYRIRGLAVNAALRGIASDSPARTDTEAVGALLYAALTQRWPYEEDAYGLTGLPKDVGLIAPDQVRAGIHRGLSELAMRALVNEGATASRQEPPCVTPDDLVKAVGEMPRVRPPEPTYTAPPDYQRTTYQQGAYARPPAVPGASPAPPPSPPAPLQTPTGKILKWGVSALLIVALGLGSWQLAEALMAGDNKNDDPSNSESSDKNSTGEKDAPAPKALKISGAQEYYPDGTPQHAGDVGKTYDGDSSTYWRTKSFTDGPDMNPAFKDGVGIVYDLGTKHPVSGASIGFRYGGDHTTVSLYAADSMSSSAPLSSMKKFATDTTSGTSAKIKAKSAVKSRYVLVWMTAMPSSGEDEFSGAGYKQAITDVKFQG
>NZ_CP045178.1|WP_077968509.1|4269235_4270027_-|RNA-polymerase-sigma-factor-SigM
MDDVTYREADDQDLLARHVAGDKDAFGELVRRHRDRLWAVALRTLGDREEAADAVQDALVSAYRRAHTFRGQSAVTTWLHRITVNACLDQARKAASRRTSPVDDTDRLEQLLDPHESAAAPAERHDLHRELLSALRTLPADQRAALVLVDMQGYPVAEAARVLEVPVGTVKSRCARGRARLIPLLSHLRNGHEPEPDPSSAKDRPRAGRPTGAPDGGEGGFPDVQVGYQRQPDPGRNRADRPSVPPAAGPMDPDALKGGGGGA
>NZ_CP045178.1|WP_077968510.1|4268054_4269239_-|hypothetical-protein
MTSATDTAGHPEVSEISDLSEGLLPPDRTADVRGHLTGCDLCTDVYASLEEIRELLGTLPGPHSMPADVAERIDAALTAEVRLDTDGAAFSGPGLSEGATRASVVSIQDDDVSRETHVGATLTSQSLPETDPGPETRLRPETTGVSRETPTTRKDHPDGQATSRDVSRETSPPDTSDTSGDSPASGSTPGTPTPLPDVDRPAGRGRAATGPGRAPVRRPSRRRSRVALGAVFAAATIGLGSLLVQSLTGDDGSGGSGATTKDAAHSFSGVELDDQVADLIGSTPSAARTADSPSTTLGTRSGGTSSSPRAPRQNTPMREGAPQIPKCVARGIGRADAPIAFERGTYRGTRAFLVVLPHVSDSTRVAAYVVDAACVDKPTTDAGKVLYKSSYARR
>NZ_CP045178.1|WP_077968511.1|4266908_4267883_-|thioredoxin-disulfide-reductase
MSDVRNVIIIGSGPAGYTAALYTARASLNPLVFEGAVTAGGALMNTTEVENFPGFQDGVMGPDLMDNMRAQAERFGAELVPDDVISTDLTGEIKTVTDTAGTVHRAKAVIVTTGSQHRKLGLPREDELSGRGVSWCATCDGFFFKDQDIAVIGGGDTAMEEATFLSRFAKSVTIVHRRDTLRASKAMQDRAFADPKIKFVWDSEVAEIHGEQKLTHLSLRNLKTDEISELPVTGLFIAIGHDPRTELFGGQLDLDDEGYLRVEAPSTRTNVTGVFGAGDVVDHTYRQAITAAGTGCSAALDAERFLAALADSEKTAEPEKTATV
>NZ_CP045178.1|WP_077968513.1|4266515_4266863_-|thioredoxin
MAGTLKHVTDDSFELDVLKNDKPVLVDFWAAWCGPCRQIAPSLEAIAAEYGDKIEIVKLNIDENPGIAAKYGVMSIPTLNVYQGGEVAKTIVGAKPKAALVRDLDEFIGDAATKA
>NZ_CP045178.1|WP_077968514.1|4265812_4266430_+|GNAT-family-N-acetyltransferase
MGRRLVPLTLDNFPDLPQRCRGCVFWELDPVRGQAALKAGTPEAEKESWISAVLLEWGSCGRVVYVDEVPVGFVMYAPPDYVPRSTAFPTSPVSPDAVLLMTAWIQPDYQGQGLGRVIVQTVAKDLLSRGFKAIEAFGDARWKAPGCVLPADHLLAVGFKTVRPHPWHPRMRLELRTTLSWKEDVEMALDRLLGKVHKEPVLRPL
>NZ_CP045178.1|WP_077968515.1|4264366_4265485_+|ParB/RepB/Spo0J-family-partition-protein
MSERRRGLGRGLGALIPAAPTAEKSSPPAAGGPKVPPAGGPVLVAERGVAAAKVTGIQSPVSRETELPQQTEPPQSADATLPETVAGTYFAELPPDEIRPNPRQPREVFDDDALAELVTSIKEVGLLQPVVVRQSESGGFELIMGERRWRACREAGLERIPAIVRATGDEKLLLDALLENLHRAQLNPLEEAAAYDQLLKDFNCTQVELADRIGRSRPQVTNTLRLLKLSPAVQRRVAAGVLSAGHARALLSVEDSEEQDRLAHRIVAEGLSVRAVEEIVTLMGSHPKSENRSRGPRAGARLSPSLTDLAGRLSDRFETRVKVDLGQKKGKIVVEFASMDDLQRILGTLAPEEGPVLPSGAVPEAAVEDEES
>NZ_CP045178.1|WP_077968492.1|4279624_4280707_-|inositol-3-phosphate-synthase
MGSVRVAIVGVGNCAASLVQGVEYYKDADPDSKVPGLMHVQFGDYHVRDIEFVAAFDVDAKKVGLDLADAIGASENNTIKICDVPNSGVTVQRGHTLDGLGKYYRETIEESQETPADIVKELKDKQVDVLVCYLPVGSEAAAKFYAQAAIDAKVAFVNALPVFIAGTKEWADKFTEAGVAIVGDDIKSQVGATITHRVMAKLFEDRGVVLDRTMQLNVGGNMDFKNMLERERLESKKISKTQAVTSQIRDRDLGADNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDALRAAKIAKDRGIGGPILSASSWFMKSPPVQYFDDEARANVEKFIAGEVER
>NZ_CP045178.1|WP_077968490.1|4280762_4281443_-|PadR-family-transcriptional-regulator
MSRRSGILEFAVLGLLRESPMHGYELRKRLNTSLGVFRAFSYGTLYPCLKTLVATGWLIEEPGSTPEDALATSLTGRRAKIVYRLTAEGKEHFEELLSQTGPDAYEDEHFAARFAFFGQTSRDVRMRVLEGRRSRLEERLEKMRASLARTRERLDDYTLELQRHGMESVEREVRWLNELIESERAGRDQRRPAPGDSAQQDTSGDTGGLPRHRDDTRPDPSEDTAK
>NZ_CP045178.1|WP_077968489.1|4281809_4284488_+|penicillin-binding-protein
MSEHRRKAPPPQGGGRAAARRGHSGTSSGRRAAPQGATGSPSASYGPEEDERPPGGRAEARRAAQRGGSRRRAAGGGGGRGGGGRRGTGGPGGWDEPPKKRFIDYPRAGKRGAERWIPSWRLVTGTFIGFFGGLLAVAGVSYALVDVPEVAKAATAQNNVYYWADGSPMVATGGETNRQIIDYNEIPESMRYAVMSAENKTFETDKGVDPMGIARAVLNMAKGGQTQGGSTITQQYVKNARLDDQGQTFSRKFKELFISIKVGATKGKEEIMAGYLNTAYYGRGAYGIQAAARAYFNVDAKKLDASQTAFLAAVLKGSTYYDPAGSVSIDPSATPQANRQRAENRWKWILDEEVKDGHLSSASRNKYATFPKVGNPRSNQRLSGQVGYLVDLARAYTVKASGGTITEGQLRQGGYEIHTTFDKKKVQELENSVKKVQKESIDVKKRPDTDKYVQFGGASVNPASGAIEAIYGGENATKHFTNNADATGAQVGSTFKPFVLAAAMKYGVRDPSGPPEQSADQRTIVSPKSIYSGKDHLKIKKYDNSVWTDKEGGEWLQANDGGDDYNPPSFDIDLREGMRVSANSVYVQLGMDVGLDKVQESAVSAGILQDSLKGAADYPSFSIGTTSPSTIRMAGAYATFANSGKQRDPYSVKEVDHGGKAVYRHEDVAKQAFDPQVADNVTDVLKTVVDKGTGTKAKLVDRPAAGKTGTTDDNKSAWFVGYTPQLSTAISMYRMDDNEKKGEKREFLKMYGTGGEKKIHGASFPSVIWHDYMETALKGKKVENFPKPEPIGKVVGAKPSPTPSPSVTESSDKPTPSTTPSATHSSEPPPSPTPDTSETSCAPLDWDCEHNGDDDGGGDGDPGDPGDGGNTGDPDPTTSEPDEPGFISGAHG
>NZ_CP045178.1|WP_077968487.1|4284741_4286280_+|DUF2029-domain-containing-protein
MAAMRSTRVQQSDQVRPTEDDEVAAAGSELIGGPIGRRALPGGHWWTPVRVIALVALGMFALGLVQKIPCYDGAWFFGASSQYTHACYSDIPHLFQGRGFADGLVPYFDKLSGDMQYLEYPVLTGVFMEVASWLTPGGDAIQHREQVYWLVNAGMLMICAVVIAVCVTRTHRRRPWDGLLLALAPAFALTATINWDLLAVALTAAAMLMWSRGRAIAFGVLLGLATAAKLYPVLLLGPLLLLCWRAGKWREFGHALGGAAGSWLVVNLPVMLLAPEGWAKFYTFSQERGVDFGSFWLLLSQHMSQPLSTDTVNTLAMVLMVLACAGIAVLTLTAPRRPRFAQLAFLVVAAFILTNKVYSPQYVLWLIPLAVLARPRWRDFLIWQAAEVVYFLGIWMYLAFTTSGDKQQGLPTGGYQLATAIHLLATLYLCAVIVRDVLLPERDVVRRPGDDDPSGGVLDGAPDLHAYGRAAQEPRHAASYDAGEAVEWGTESGRRKPAWGVADDDEEGRQGP
>NZ_CP045178.1|WP_077968485.1|4286455_4287487_-|alanine-racemase
MALTLYVDTARWRAHQKHVLDQFPGLVPVCKGNGYGFGHERLAEEATRFGSDILAVGTTYEAARIKDWFSGDLLVLTPFRRGEEPVPLPDRVIRSVSSIDGVHGLVGARVVIEVMSSMKRHGVTEQDLPQLQNAIDDVRLEGFAIHLPLDRTDGTDAVDEVITWMDRLRAARLPLHTMFVSHLKADELARLRQQFPQTLFRARIGTRLWLGDDDATQYRGAVLDVTRVAKGDRFGYRQQKAASDGYLVVVAGGTSHGVGLEAPKALHGMMPRAKGVARAGLATVNRNLSPFVLGAKQRWFAEPPHMQVSILFVPGDAPEPHVGEELVAHLRHTTTQFDRIVDR
>NZ_CP045178.1|WP_077968483.1|4287558_4288680_-|peptidoglycan-bridge-formation-glycyltransferase-FemA/FemB-family-protein
MTLTLRTISREQHLAYIQSLPAASHMQVPAWAEVKSEWRSESLGWFDDRTGQMVGAGLVLYRQLPKIKRYLAYLPEGPVINWYAPNLDEWLRPMLAHLKQQGAFSVKMGPPVVIRRWEAPTIKKGIQDPDVKRLRDIEADVIEPRAFEVSDKLRKMGWQQGEDGGAGFGDVQPRYVFQVPLANRSLEDVHKGFNQLWRRNIKKAEKAGVEVVQGGYQDLAEWQRLYEITAVRDRFRPRPLAYFERMWSALNSEDPNRMRLYFARHNGVNLSAATMLVVGGHVWYSYGASDNIGREVRPSNAMQWRMLRDSYALGATVYDLRGISDSLDENDHLFGLIQFKVGTGGEAAEYLGEWDFPLNKLLHKALDIYMSRR
>NZ_CP045178.1|WP_077968481.1|4288856_4289171_-|hypothetical-protein
MAQSMRSHTTSPLLAGDGRSHPLQDTLVLVTLALGVLAVVSAAFNNLHLLSSWAGLVGILTGAYGQFISATTRERFGLVVGLGAAAVGFFIGMAHGGLFGGVIG
>NZ_CP045178.1|WP_059143728.1|4289438_4289729_+|30S-ribosomal-protein-S6
MRHYEVMVILDPDLEERAVSPLIENFLSVVREGEGKVEKVDTWGRRRLSYEIKKKPEGIYSVIDLQAEPAVVKELDRQMNLNESVLRTKVLRPETH
>NZ_CP045178.1|WP_077968478.1|4289801_4290410_+|single-stranded-DNA-binding-protein
MAGETVITVVGNLVDDPELRFTPSGAAVAKFRVASTPRTFDRQTNEWKDGESLFLTCSVWRQAAENVAESLQRGMRVVVQGRLKQRSYEDREGIKRTVYELDVEEVGASLKNATAKVTKTTGRGGQGGYGGGNGGGGQQGGAWGGGSGGGQQQGGGGAPSDDPWATGAPAGGGQQGGGGGGGWGGNSGGGGAGGGYSDEPPF
>NZ_CP045178.1|WP_003949403.1|4290453_4290690_+|30S-ribosomal-protein-S18
MAKPPVRKPKKKVCAFCKDKVTYVDYKDTNMLRKFISDRGKIRARRVTGNCTQHQRDVATAVKNSREMALLPYTSTAR

Crispr_ID: NZ_CP045178_13

• CRISPR_ID: NZ_CP045178_13
• CRISPR_location: 4657659-4657787
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas3

Consensus repeat of NZ_CP045178_13

Consensus_repeat	Method
CGGCCTCGGAGGGATGGACATCGGCCGTGGTGGGACGGG	CRISPRCasFinder

spacers of NZ_CP045178_13

>13.1|4657698|51|NZ_CP045178|CRISPRCasFinder
CATCGGCCGTGGTGGGACGGGCTTCGGCCTCGGACTAGGCGGGACGGGTTC

CRISPR arrays and Neighbor proteins around NZ_CP045178_13

CRISPR arrays

The CRISPR arrays of NZ_CP045178_13

>merge|NZ_CP045178|13|4657659-4657787|CRISPRCasFinder
CGACGGGGGAGGGAGGGGCTTCGGCCTCGGAGGGATGGACATCGGCCGTGGTGGGACGGGCTTCGGCCTCGGACTAGGCGGGACGGGTTCCGGCCTCGGAGGGATGAACATCGGCCGTGGTGGGACGGG

>NZ_CP045178|13|10|4657659-4657787|CRISPRCasFinder
CGACGGGGGAGGGAGGGGCTTCGGCCTCGGAGGGATGGA	CATCGGCCGTGGTGGGACGGGCTTCGGCCTCGGACTAGGCGGGACGGGTTC
CGGCCTCGGAGGGATGAACATCGGCCGTGGTGGGACGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077966668.1|4664881_4665223_+|STAS-domain-containing-protein	unknown	unknown	gnl|CDD|132914
NZ_CP045178.1|WP_077966671.1|4666617_4669107_+|sodium-translocating-pyrophosphatase	unknown	unknown	gnl|CDD|234827
NZ_CP045178.1|WP_107502745.1|4669387_4669987_+|small-secreted-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966849.1|4657881_4658910_+|hypothetical-protein	unknown	unknown	gnl|CDD|227300
NZ_CP045178.1|WP_077966652.1|4641876_4642377_-|phage-holin-family-protein	unknown	unknown	gnl|CDD|377816
NZ_CP045178.1|WP_077966669.1|4665337_4665772_+|ATP-binding-protein	unknown	unknown	gnl|CDD|379279
NZ_CP045178.1|WP_077966662.1|4653379_4654216_-|HAD-IB-family-hydrolase	unknown	unknown	gnl|CDD|273654
NZ_CP045178.1|WP_107502742.1|4644620_4646573_-|acetate--CoA-ligase	unknown	unknown	gnl|CDD|234677
NZ_CP045178.1|WP_077966673.1|4672172_4674662_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP045178.1|WP_077966659.1|4649693_4650968_+|hypothetical-protein	unknown	unknown	gnl|CDD|200598
NZ_CP045178.1|WP_077966653.1|4642771_4644148_-|Na+/H+-antiporter-NhaA	unknown	unknown	gnl|CDD|184855
NZ_CP045178.1|WP_077966663.1|4656421_4657627_+|TadA-family-conjugal-transfer-associated-ATPase	unknown	unknown	gnl|CDD|200328
NZ_CP045178.1|WP_077966850.1|4662087_4662381_+|flp-pilus-assembly-TadE/G-like-family-protein	unknown	unknown	gnl|CDD|274799
NZ_CP045178.1|WP_077966679.1|4675684_4678552_+|type-I-DNA-topoisomerase	unknown	unknown	gnl|CDD|236048
NZ_CP045178.1|WP_077966657.1|4646903_4649348_-|transporter	unknown	unknown	gnl|CDD|223732
NZ_CP045178.1|WP_107502758.1|4658983_4659742_+|type-II-secretion-system-F-family-protein	unknown	unknown	gnl|CDD|366122
NZ_CP045178.1|WP_077966845.1|4652072_4652912_+|oxidoreductase	unknown	unknown	unknown
NZ_CP045178.1|WP_107502744.1|4662343_4664773_-|DEAD/DEAH-box-helicase	cas3	mkCas0139_cas3_CAS-I	gnl|CDD|274800
NZ_CP045178.1|WP_077966661.1|4650948_4651971_-|ATP-binding-protein	unknown	unknown	gnl|CDD|349754
NZ_CP045178.1|WP_077966847.1|4654758_4655952_+|septum-formation-initiator	unknown	unknown	gnl|CDD|274798

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP045178.1|WP_107502744.1|4662343_4664773_-|DEAD/DEAH-box-helicase	cas3	mkCas0139_cas3_CAS-I	4e-11	36.4	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077966668.1|4664881_4665223_+|STAS-domain-containing-protein	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	4.98727e-34
NZ_CP045178.1|WP_077966671.1|4666617_4669107_+|sodium-translocating-pyrophosphatase	gnl|CDD|234827	PRK00733, hppA, membrane-bound proton-translocating pyrophosphatase; Validated.	0
NZ_CP045178.1|WP_077966849.1|4657881_4658910_+|hypothetical-protein	gnl|CDD|227300	COG4965, TadB, Flp pilus assembly protein TadB [Intracellular trafficking and secretion].	1.30486e-17
NZ_CP045178.1|WP_077966669.1|4665337_4665772_+|ATP-binding-protein	gnl|CDD|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	8.40787e-31
NZ_CP045178.1|WP_077966662.1|4653379_4654216_-|HAD-IB-family-hydrolase	gnl|CDD|273654	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490. This hypothetical equivalog is a member of the IB subfamily (TIGR01488) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The sequences modelled here are all bacterial. The IB subfamily includes the enzyme phosphoserine phosphatase (TIGR00338). Due to this relationship, several of these sequences have been annotated as "phosphoserine phosphatase related proteins," or "Phosphoserine phosphatase-family enzymes." There is presently no evidence that any of the enzymes in this model possess PSPase activity. OMNI|NTL01ML1250 is annotated as a "possible transferase," however this is due to the C-terminal domain found on this sequence which is homologous to a group of glycerol-phosphate acyltransferases (between trusted and noise to TIGR00530). A subset of these sequences including OMNI|CC1962, the Caulobacter crescentus CicA protein cluster together and may represent a separate equivalog. [Unknown function, Enzymes of unknown specificity].	2.07098e-62
NZ_CP045178.1|WP_107502742.1|4644620_4646573_-|acetate--CoA-ligase	gnl|CDD|234677	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional.	0
NZ_CP045178.1|WP_077966673.1|4672172_4674662_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.06453e-81
NZ_CP045178.1|WP_077966659.1|4649693_4650968_+|hypothetical-protein	gnl|CDD|200598	cd10976, CE4_CDA_like_3, Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins. The family includes many uncharacterized bacterial hypothetical proteins that show high sequence similarity to insect chitin deacetylase-like proteins. Chitin deacetylases (CDAs, EC 3.5.1.41) are secreted metalloproteins belonging to a family of extracellular chitin-modifying enzymes that catalyze the N-deacetylation of chitin, a beta-1,4-linked N-acetylglucosamine polymer, to form chitosan, a polymer of beta-(1,4)-linked d-glucosamine residues.	6.09304e-138
NZ_CP045178.1|WP_077966653.1|4642771_4644148_-|Na+/H+-antiporter-NhaA	gnl|CDD|184855	PRK14853, nhaA, pH-dependent sodium/proton antiporter; Provisional.	0
NZ_CP045178.1|WP_077966663.1|4656421_4657627_+|TadA-family-conjugal-transfer-associated-ATPase	gnl|CDD|200328	TIGR03819, heli_sec_ATPase, helicase/secretion neighborhood ATPase. Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.	5.09652e-160
NZ_CP045178.1|WP_077966850.1|4662087_4662381_+|flp-pilus-assembly-TadE/G-like-family-protein	gnl|CDD|274799	TIGR03816, tadE_like_DECH, helicase/secretion neighborhood TadE-like protein. Members of this small, highly hydrophobic protein family occur in a pilus/secretion-like region that usually is next to an uncharacterized DEAH-box helicase, in Actinobacteria. Members show sequence similarity to the TadE-like family described by pfam07811. The function is unknown. [Unknown function, General].	9.92449e-06
NZ_CP045178.1|WP_077966679.1|4675684_4678552_+|type-I-DNA-topoisomerase	gnl|CDD|236048	PRK07561, PRK07561, DNA topoisomerase I subunit omega; Validated.	0
NZ_CP045178.1|WP_077966657.1|4646903_4649348_-|transporter	gnl|CDD|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	1.80466e-97
NZ_CP045178.1|WP_107502758.1|4658983_4659742_+|type-II-secretion-system-F-family-protein	gnl|CDD|366122	pfam00482, T2SSF, Type II secretion system (T2SS), protein F. The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).	1.19117e-10
NZ_CP045178.1|WP_077966652.1|4641876_4642377_-|phage-holin-family-protein	gnl|CDD|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	1.09838e-16
NZ_CP045178.1|WP_107502744.1|4662343_4664773_-|DEAD/DEAH-box-helicase	gnl|CDD|274800	TIGR03817, DECH_helic, helicase/secretion neighborhood putative DEAH-box helicase. A conserved gene neighborhood widely spread in the Actinobacteria contains this uncharacterized DEAH-box family helicase encoded convergently towards an operon of genes for protein homologous to type II secretion and pilus formation proteins. The context suggests that this helicase may play a role in conjugal transfer of DNA.	0
NZ_CP045178.1|WP_077966661.1|4650948_4651971_-|ATP-binding-protein	gnl|CDD|349754	cd02034, CooC1, accessory protein CooC1. The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.	5.26735e-35
NZ_CP045178.1|WP_077966847.1|4654758_4655952_+|septum-formation-initiator	gnl|CDD|274798	TIGR03815, CpaE_hom_Actino, helicase/secretion neighborhood CpaE-like protein. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins (see ). Nearly all members are found, not only in a gene context consistent with pilus biogenesis or a pilus-like secretion apparatus, but also near a DEAD/DEAH-box helicase, suggesting an involvement in DNA transfer activity. The model describes a clade restricted to the Actinobacteria.	1.76237e-74

Protein sequences

>NZ_CP045178.1|WP_077966663.1|4656421_4657627_+|TadA-family-conjugal-transfer-associated-ATPase
MSTVVADGLLDGVRQWLAERGAEPTPARVAQALREQGRVLGDSEVLRAAGRLRSELVGAGPLEPLLADPDVTDVLVAGPDRVWVERGGGLELTSVRFTDATAVRRLAQRLAAVAGRRLDDARPWVDARLPDGTRLHAVLPPVAVESTCLSPRVVRPRAFTLAELIEAGTVPPGGDTVLRALIDARLSFLVSGGTGSGKTTLLSALLGLAGPGERIVLAEDSAELRPEHPHVVRLETRPANQEGAGLVTLRDLVRQTLRMRPDRLVVGEVRGAEVVHLLAALNTGHAGCGTVHANTASDVPARLEALGTAAGLDRAALHSQLAAALAVVLHLVRDGAGRRRIAELRVLDRDPSGLVVTVPALRGGGGGFVRERGWERLRGLLTGSAACGRASGAGELERAVL
>NZ_CP045178.1|WP_077966847.1|4654758_4655952_+|septum-formation-initiator
MTGDSAFEPPFAASTARGGPLIVTEDPDLLDDLLRLCAAAGTRPEVHHGVPRERGRWEAAPLVLVGDDATARVSGAARRRGVLLVGRDQDDPEVWRRAVGIGAEHVLLLPDAEEWLVDRIADLAEGTGAPALTVGVMGGSGGVGASTLSCALAITAAAAGRRSLLVDADPLGGGLDVLLGGEGAEGLRWPAFARSRGRVGGTALEESLPELHGLRLLSWDRGDSVHLPPQAVRAVLAAARRRGGVVVVDLPRRIDESATEALAQLDLLLLTVQGELRAVAAARRVASLLSMVVRDVRAVVAPSPAGVRPGLEAATVADLLDMPLAGELPHEPGLLAAQTEGAPPGSVRRGPLAGFCEAFWERLPEAATPGAPAGQGGSPRMSGPGGRSDSFERGTAP
>NZ_CP045178.1|WP_077966662.1|4653379_4654216_-|HAD-IB-family-hydrolase
MLGHVENHSSPRTAAFFDLDKTVIAKSSTLTFSKSFYQGGLINRRAALRTAYTQFVFLVGGADHDQMERMRSYLSALCRGWNVRQVQEIVAETLHDLIDPIIYDEAASLIEEHHTAGRDVVIVSTSGAEVVEPIGELLGADRVVATRMVVGDDGCFTGEVEYYAYGPTKAQAVRDLAESEGYDLTRCYAYSDSATDIPMLEAVGHPFAVNPDRTLRKEAATRGWPVLDFHRPVRLKQRLPTFSVPPRPALMAAAAVGAAAAAGFVWYTSRRRTSAGAS
>NZ_CP045178.1|WP_077966845.1|4652072_4652912_+|oxidoreductase
MSTTGSTADPLAVLGDLPGVAESVDSVRKAVDRVYGHRVMRRRSHEITSEAALRGARGSAALSGADWALEEVRRRTDFGAGAGVEALTVGAALRLSAEAGQLLSIWQQSPLRVLARLHLVAGAGADAAGERVGRPRLAGEPVDEPLVELELPGADEVAGRLEGLAALVTAGSSAPALVMAAVVHGELLALRPFGSCNGPVARAAERIILVGSGLDPKSVCPAEVGHAELGRAAYVAALEGYVSGTPEGMAAWITHCGRAVELGARESTAVCEAMQRGAA
>NZ_CP045178.1|WP_077966661.1|4650948_4651971_-|ATP-binding-protein
MKIAFVGKGGSGKTTLSSLFIRHLATTTSPVMAVDADINQHLGAALGLDEEEAASLPAMGARLSLIKNYLRGSNPRITGAETMIKTTPPGEGSRLLRLREDNPVYDACARRVALDDGEVRLMATGPFTEADLGVACYHSKVGAVELCLNHLADGRDEYVVVDMTAGSDSFASGMFTRFDMTFLVAEPTRKGVSVYRQYKEYARDFGVALKVVGNKVQGQDDIDFLREETGEDFLVPFGQSDWVRAMEKGRPARFDTLEEPNRAALRTLRATVDASYGRRDWERFTRQTVHFHLKNAKSWGNERTGADLAAQVDPAFVLREGGTATLRGSREASAATAQPA
>NZ_CP045178.1|WP_077966659.1|4649693_4650968_+|hypothetical-protein
MAATRRITAGVTVAAACAVALAGCGEQPREERPVPPKKAAPAPAPKNAVRLIGDGSTAFTGSQPRLARPERLRPGQKPPQFVVFSWDGAGEDSQKLFSHFRKVAKANKATMTYFLSGVYMLPEEERNLYHAPQHSSGRSDIGFNDRTGIANTVAQLRGAWLEGNEIGTHFNGHFCGKDGGVGQWSVDEWKSEIRQAKSFVKAWKSHTGLKGEAPLPFDYEKELIGGRTPCLEGQKNFIEAGRDMGFRYDTSGVNDQVWPKKKQGLWDLSMQLVPVPGRSFETLTMDYNFMVNQSGTATQGDPDKHAYWGDQMRDGLLQGFERAYRGNRAPLVIGNHFESWNGGAYMRAVEQTIERVCTRSEVRCVSFRQLADWLDAQDPKLLARLSGLGVGKAPKEGWASFLSARPAPAPKGVPGAPAVKPAER
>NZ_CP045178.1|WP_077966657.1|4646903_4649348_-|transporter
MSACVSTRAPQGAPPPPGDAVSHSPPPVPPRRKFRIAGADLSASVAVFLIALPLSLGIALATGAPLQAGLVAAAVGGLVAGRFGGSPLQVSGPAAGLTVVTADLIHQYGWRATCAITVAAGLAQLGLALLKVARSALAVSPAIVHGMLAGIGVTIAVAQAHVVIGGTPQSSVLDNLLGLPAQLADVHWSALSMSALTLAVLFLWPRLPGRGGQLARKVPAALIAVVAATAVASFAGLSLPKVDLPSWSNHALPGLPEGPVLSLVAGVVTVTLVTSVQSLLGAVAVDKLVAGRPDQAARVPRSGLDRELLGQGAANITSGALGGLPVAGVAVRSSANIRAGAVSRHSTMLHGVWVLIAALLLVPVLELIPLSVLAALVMSVGAAMVNPHHIRTVTRHREILVYTVTTLGVVFLGVLEGVALGIAVAVGVALHRLTHTRITRTEKDGTHHLRVRGQLTFLAVPRLSRALHGVPRGSAVVVELDGSYMDHAAYETLNDWQLSHTTQGGTVEMTGRAGTRITDQGSSAQTCCRPWAPWHNHHCDRPDAPSDSVHRGGHQLASGISAFQRDTAPQVRGELARLAREGQQPSQLFLTCADSRLVTSMITSSGPGDLFTVRNVGNLVPLPGAESGDDSVAAAIEYAVDVLRVRSITVCGHSGCGAMQALLDNASKTPVTTPGPPPAASGGEPTTPLRRWLSHGGPSLARLTDGGRPRAGLAGREPADTVEQLCLVNVVQQLEHLRAHESVAGRLADGSLELHGMYFHVGEAQAYLLNGSDPGGSGSGPSGGGPLGVPGKDGGDKVEFFDRVAPSDLQGAGS
>NZ_CP045178.1|WP_107502742.1|4644620_4646573_-|acetate--CoA-ligase
MSNESLANLLREERRFAPPADLAAAANVKAEAYEQAKADRLGFWAEQARRLTWATEPTETLDWSNPPFAKWFADGELNVAYNCVDRHVEAGNGGRVAIHFEGEPGDSRAITYAELKDEVSRAANALLELGVRKGDRVAVYLPMIPEAVFAMLACARIGAAHSVVFGGFSADAIAARIADADAKVVITSDGGYRRGKPSALKPAVDDAVARFDTVEHVVVVRRTGQDIAWNDRDVWWHEVTGRQSAEHTPEAFDAEHPLFILYTSGTTGKPKGILHTSGGYLTQASYTHHAVFDLKPETDVYWCTADIGWVTGHSYIVYGPLSNGATQVLYEGTPDTPHQGRFWEIVQKYGVSLLYTAPTAIRTFMKWGDDIPAKFDLSSLRVLGSVGEPINPEAWMWYRENIGKGKCPIVDTWWQTETGAMMIAPLPGVTHTKPGSAQRALPGISATVVDDEGHEVPDGGGGYLVLTEPWPSMLRTIWGDDQRFLDTYWSRYEGKYFAGDGAKKDDDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHPSVAEAAVVGAADETTGQAIVAFVILRGTAAESDDLVAQLRNHVGSALGPIAKPKRVLPVAELPKTRSGKIMRRLLRDIAENRELGDVSTLTDSSVMDLIQTKLPSASSED
>NZ_CP045178.1|WP_077966653.1|4642771_4644148_-|Na+/H+-antiporter-NhaA
MAPPPRSPLPGRTLLGRLPLPERAAVAEALRTETVGGVLLLVGAVAALVWANTPLVDSYEAVRDFHFGPSTLGLHLSVEHWASDGLLAVFFFVAGVELKRELVAGELRDPKTAVLPVVAAACGMLVPALVYTLVSSAGGGSLSGWAVPTATDIAFALAVLAVLGTSLPSALRAFLLTLAVVDDLGAILIIAVFFTSDIDFLALAGAAVGLGLFWVLLRTGVKGWYVYVPLALVIWGLMYNSGIHATIAGVAMGLMLRCTRREVAEPADVEGRAPEAAGPPDGEGRRWEAYSPGERVEHLVRPLSAGVAVPLFALFAAGVSVTGGALTDVFTRPETLGVVLGLVAGKTIGVFFGTWCTARFTRASLSAELAWADVFAVATLAGIGFTVSLLIGELAFTGDAGLVDEVKASVLVGSVIAVLLAGVLLRARNGVYRRLRDEEEHGGDLAGVRDTHGEENRG
>NZ_CP045178.1|WP_077966652.1|4641876_4642377_-|phage-holin-family-protein
MSAPDSADRSLGQLVATAADEMSSLMHDEIALAKAQLRHDVKRGAVSGGAGAVAAAVLIFSLPMLSFALAYGIQSWSGWHISVCFLLSFAASVLVAGLLGLIAMVFAKKAKNGKGPQKTVASAKETAAVLGHVKPHPRAEIPDLTRFPALNERGGETAPAVARSSS
>NZ_CP045178.1|WP_077966849.1|4657881_4658910_+|hypothetical-protein
MAGTPHGGPLAALTVTAALLFAGAAAWTWDTGDSRRTRHALLVLEGRSLPAPGLAILTRWYAWLRCHLRREWSCVAVGAVVAVLGASPLPLLLGGAAVVPVRGALRAREEKRLRDIRADAVITLCGVLAGEVRAGGQPGQALLIAARESGGLGDAEPAVLAAARFGGDVPEMLRHASDQPGAEGLLGLAACWRVAVDRGAGLANGLERLEAVLRSDRDQRADLRAQLAGARSTAVLLAFLPVMGLALGTALGAEPLRVLLHTPAGLGCVAVGGLLEATGLWWALAIVGRAEGGGNAEARKRRPSAGQGEVRRRTVGGRERGAYGGHREWGARGALAKAGTER
>NZ_CP045178.1|WP_107502758.1|4658983_4659742_+|type-II-secretion-system-F-family-protein
MAVAFLATVLSVRREERVTGRRLDRIRMRGVSGGSGRRWPASGAGAARKYLPVVGVVAGGYALVGGFVGLLVGLVAAGGVEWQRRRVAVRDPGDREADNDLAAARAQLPLAADLLSACIAAGAGPVAAARAVGESLDGPVGVRLAQAAAEVRLGGEPAEAWRRVGALPGAAALARLLERSGESGAPAAEPVARLAAECRAEWARDSTARVRRAAVLVTAPVGLCFLPAFLTVGVVPVLIGLTGDLLQAGIGK
>NZ_CP045178.1|WP_077966850.1|4662087_4662381_+|flp-pilus-assembly-TadE/G-like-family-protein
MAVVGIVFAAALGMGQAVVAKHRAGAAADMGALAAAGRWADGAEEACAGARRVAEAQGGRIARCAVRGEVSDVTAVVEFGPWAARVRARAGPPGAAP
>NZ_CP045178.1|WP_107502744.1|4662343_4664773_-|DEAD/DEAH-box-helicase
MHDAFGPLWVTPVTHSMPMADFFTPGRPRAGTAAQPSPRAVLDRLSAGPGRAARITHTEHLPPRAARYAVWPDRVRSEVIAAVQAAGIEHPWAHQARAAEHALDGESVVVSTGTASGKSLGYLVPVLSTLLDGSEAPNGRGTTSLYLAPTKALAADQRRAVRELADPLGRAVRPAVYDGDTPVEEREWVRQYANYVLTNPDMLHRSILPSHPRWASFLRALRYVVIDECHTYRGVFGSHVAQVLRRLRRLCARYGANPVFLLASATAAEPSVAAERLTGVPVVEVADDASPRGEVVFALWEPPLTELHGEKGAPVRRTATAESADLLTDLTLQGVRSVAFVRSRRAAELISVIAKERLGEFDRALPGRVAAYRGGYLPEERRALERALHTGELLGLAATTALELGVDVSGLDAVVIAGYPGTRASLWQQAGRAGRSGQGALAVLVARDDPLDTFLVHHPEAIFDQPVESTVLDPDNPYVLAPHLCAAAAELPLTEEDLPLFGPATVELLPQLESAKLLRRRTKAWHWTRRERAADLTDIRGEGGTPVQVVEKGTGRLLGTVDASAAHTTVHDGAVHLHQGRTYQVKHFDIDDSVALVEEANPPYSTTARDTTAISVLETDIEIPWGEGRLCYGSVEVTNQVVAFLRRRLITGEVLGETKLDLPPRTLRTRAVWWTVTEDQLDAARVNPEQLGGALHAAEHASIGMLPLFATCDRWDIGGVSIPLHPDTLLPTVFVYDGHPGGAGFSERAFHTAREWLTATREAIASCECDAGCPSCVQSPKCGNGNEPLHKRAAVRLLTVLLQGAPPAP
>NZ_CP045178.1|WP_077966668.1|4664881_4665223_+|STAS-domain-containing-protein
MDLSLSTRTVGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSFHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHNSVEEAVEATD
>NZ_CP045178.1|WP_077966669.1|4665337_4665772_+|ATP-binding-protein
MATVELRFSALPEHVRTARLVAAAVARRAGVDEAVLDEVRLAVGEACTRAVGLHQSNGVTAPVSVSLIEEEKQFSIEVADEAPHASSADATPEDLLGSDNLDTEGEDEMGLAVISGLVDDVEVVTGESGGRIRMTWPAAPAVLA
>NZ_CP045178.1|WP_077966671.1|4666617_4669107_+|sodium-translocating-pyrophosphatase
MAELSVLQQLEQPSTTFAAAVLTDDNRLIVVVIAVVAVLALVLAGVLVRQVLAADEGTARMKEIAAAVQEGANAYLARQLRTLAIFAAVVFFLLLLLPADDWNQRIGRSIFFLVGAGFSAATGYMGMGLAVRSNVRVAAAAREATPASGGKSGAGGAGETGEVVERRKAELTTVSHKAMKIAFRTGGVVGMFTVGLGLLGASCVVLVYAADAPKVLEGFGLGAALIAMFMRVGGGIFTKAADVGADLVGKVEKGIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVAALILGKVAFGDAGLALPLMIPAIGVVTAMIGIFAVSPRRRDRSGMSAINRGFFISAVISLVLVAVAVYVYLPATYAELDGVTDAAIRGDGGDPRVLALVAVAIGIVMAALIQQLTGYFTETSRRPVRDIGKSSLTGPATVVLAGISVGLESAVYTALLIGLGVYGAFLLGGTSIMLALFAVALAGTGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGDVEGAGAQVLTDLDAVGNTTKAITKGIAIATAVLAASALFGSYRDAITTAAKDVGEKVGEGGPLNLVMDISQPNNLVGLVLGAAVVFLFSGLAINAVSRSAGAVVYEVRRQFRERPGIMDYTEKPEYGRVVDICTKDALRELATPGLLAVMAPIAVGFTLGVGALGAYLAGAIGTGTLMAVFLANSGGAWDNAKKLVEDGHHGGKGSEAHAATVIGDTVGDPFKDTAGPAINPLLKVMNLVALLIAPAIVRFGYGEDANAWLRALIAVIAIVVIVVAVYVSKRRGIAVDDNVGTGDPASGGGGGNPGRGEPHSDPAVLS
>NZ_CP045178.1|WP_107502745.1|4669387_4669987_+|small-secreted-protein
MEGTNPVNKKLAAVLSSGAVLGLALTLTGCGDDSDDKLNSWAKTVCDDVQPQAKKIESANAAIQQQTSDNSKPEDVQKTDSKAFQDMSDAYKAMGNAVQKAGNPPVDGGDKTKSDAVRELKSISASYGDLKKQVDALDTKDQSKFADGLKGVAGELSKLSKSGNNALDKLQSGDVGKAMKKQKSCQSSSASASPAPSNA
>NZ_CP045178.1|WP_077966673.1|4672172_4674662_+|serine/threonine-protein-kinase
MSEQNGIGGTDEAAGRVVAGRYRLRKRLGAGGMGRVWLAHDEKLGADVAVKEIAVPPGVAEDSLSNKVARAISEAKNAALLRGHPHVVTVYDVFELDGLPWIVMAYVPGAVDLDVMVRASGTLSSAQVARVGRAVLGALSEGHAADVLHRDVKPANLLLAPDPSGDPFGRVLLTDYGISLRPGSGDPRLTAAADLIGTPGYMAPERARGAAPSPAADLFSLGATLYFAAEGVGPFAREGEINTFSALLLDPPPPMTRVSPLLAHAVLGLLAKTPEQRTGAEETDARLAAVLDEEGTRAAGAPPFGRPGRPARTVSLRKRKQDMFGADVPVPGDHAPEWTSARAPGTPGPDADTGPSPVTGSHPATGSHPETGPYRATALGFDTAARPAAASPPAAAPGPTATPGPSAAPGPAAVPHPATPGTGSSATGHPGTPGDPPPDRATPPTSAMPPDRATPPISATPPVRACAGPATPASATPVGPFASPGSSIAGRPVPAAPSGVDVTSTLGGKRGSEAGRRPGSSSSGRRRWRPSRPVTAIVALTLLVAGVALWGAHQLTGDGGRNEAGRSSGSGSGTGRSEGRTDGSGGGSSGDSGAYPYGENVGLISALKPGQCVQVSWPREKYEGVAALADGGCDDNPDGQVTSEYEVTNASQAAKNGTKRCADRSKALTDKLPGAFSYAVVPTKAAIEAGDGRAAVACVLLVRDLTLGGRAGDYRSMGEEVNIGNTSVGDCVDITKKTTWLLARCAAPHSEQIVGWVRQSATMSDKEFAENISVLCDKRYAAAWVRDQNHMITGWHIDEEPDYPYGLCMLAQSDGGTLPGGKAEPINGR
>NZ_CP045178.1|WP_077966679.1|4675684_4678552_+|type-I-DNA-topoisomerase
MSPTSETAHGGRRLVIVESPAKAKTIKGYLGPDYTVEASVGHIRDLPSGAAEVPEKYTGEVRRLGVDVENDFQPIYVVNADKKSQVKKLKDLLRDSDELFLATDEDREGEAIAWHLQEVLKPKIPVHRMVFHEITKDAIRAAVASPRELNKKLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFGPAAGGPADGAGDPSTFAARLSAVDGKRVAQGRDFDSVGRLKSDTLQLDEASARALAAALADSSFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYENGYITYMRTDSTTLSDTAVSAARAQVTQLYGANYLPEKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETPLTGDQRRLYELIWKRTVASQMKDAVGNSVTVKIAGTASDGRDAEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQVEQGDALTAQEITADGHSTKPPARYTEASLVKELEEREIGRPSTYASILGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLKHFYFGEGDGAGVAAEAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGDGIMLRVGRYGPYIERGEKDAENHQRADVPEDLAPDELSVEYAEELLAKPSGDFELGAEPETGRQIIAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGVDADGVEITAQNGRYGPYLKKGTDSRSLQTEDQLFTITVDEALAIYAQPKQRGRAAAKPPLKELGEDPVSGKPVVVKDGRFGAYVTDGETNATLRASDSVEEITAERGFELLEEKRAKGPAKKTAKKAVKKTAAKKAPAKKTAAATKTAAKKTSAAAKKTSTKTSTAAKKATTAAKKATSSASTSSED

Crispr_ID: NZ_CP045178_14

• CRISPR_ID: NZ_CP045178_14
• CRISPR_location: 4829924-4830127
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_CP045178_14

Consensus_repeat	Method
CCTCCACCGGGNNTGGGC	CRT

spacers of NZ_CP045178_14

>14.1|4829942|18|NZ_CP045178|CRT
AGTCCGGCCGTGGGGGGT
>14.2|4829978|24|NZ_CP045178|CRT
AGTCCTCCACCGTCCCTCAGGGGT
>14.3|4830020|18|NZ_CP045178|CRT
AGTCCGGCCGTGGGGGGT
>14.4|4830056|18|NZ_CP045178|CRT
AGTCCGGCCGTGGGGAGT
>14.5|4830092|18|NZ_CP045178|CRT
AGTCCGGCCGTGGGGAGT

CRISPR arrays and Neighbor proteins around NZ_CP045178_14

CRISPR arrays

The CRISPR arrays of NZ_CP045178_14

>merge|NZ_CP045178|14|4829924-4830127|CRT
CCTCCACCGGGCGTGGGCAGTCCGGCCGTGGGGGGTCCTCCACCGGGCGTGGGCAGTCCTCCACCGTCCCTCAGGGGTCCTCCACCGGGCGTGGGCAGTCCGGCCGTGGGGGGTCCTCCACCGGGCGTGGGCAGTCCGGCCGTGGGGAGTTCTCCACCGGGTATGGGCAGTCCGGCCGTGGGGAGTCCTCCACCGGGTATGGGC

>NZ_CP045178|14|4|4829924-4830127|CRT
CCTCCACCGGGCGTGGGC	AGTCCGGCCGTGGGGGGT
CCTCCACCGGGCGTGGGC	AGTCCTCCACCGTCCCTCAGGGGT
CCTCCACCGGGCGTGGGC	AGTCCGGCCGTGGGGGGT
CCTCCACCGGGCGTGGGC	AGTCCGGCCGTGGGGAGT
TCTCCACCGGGTATGGGC	AGTCCGGCCGTGGGGAGT
CCTCCACCGGGTATGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_107502761.1|4879100_4879985_+|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|270410
NZ_CP045178.1|WP_077966815.1|4881083_4882127_+|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|237845
NZ_CP045178.1|WP_107502760.1|4877054_4877504_+|methylmalonyl-CoA-mutase	unknown	unknown	gnl|CDD|239023
NZ_CP045178.1|WP_077966771.1|4784857_4788172_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|163057
NZ_CP045178.1|WP_077966772.1|4788520_4789891_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|274856
NZ_CP045178.1|WP_077966777.1|4798233_4798566_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|377587
NZ_CP045178.1|WP_077966813.1|4880085_4881087_+|DMT-family-transporter	unknown	unknown	gnl|CDD|223769
NZ_CP045178.1|WP_077966795.1|4803240_4803657_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_143621193.1|4848942_4867704_+|lonely-Cys-domain-containing-protein	unknown	unknown	gnl|CDD|380151
NZ_CP045178.1|WP_107502753.1|4867711_4868554_+|type-VII-secretion-system-associated-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966773.1|4790370_4794333_-|type-VII-secretion-protein-EccCa	unknown	unknown	gnl|CDD|274858
NZ_CP045178.1|WP_143621196.1|4873316_4874963_+|hypothetical-protein	unknown	unknown	gnl|CDD|366226
NZ_CP045178.1|WP_107502754.1|4868937_4873284_+|hypothetical-protein	unknown	unknown	gnl|CDD|223021
NZ_CP045178.1|WP_077966774.1|4794683_4796084_+|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl|CDD|274855
NZ_CP045178.1|WP_077966776.1|4797799_4798129_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966800.1|4875773_4876673_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NZ_CP045178.1|WP_077966787.1|4798724_4799225_+|type-VII-secretion-system-associated-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966794.1|4802779_4803244_+|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl|CDD|376829
NZ_CP045178.1|WP_077966775.1|4796100_4797699_+|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288
NZ_CP045178.1|WP_077966811.1|4877518_4878874_+|methylaspartate-mutase	unknown	unknown	gnl|CDD|238149

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_107502761.1|4879100_4879985_+|transporter-substrate-binding-domain-containing-protein	gnl|CDD|270410	cd13692, PBP2_BztA, Substrate bindng domain of ABC glutamate/glutamine/aspartate/asparagine transporter; the type 2 periplasmic binding protein fold. BztA is the periplamic-binding protein component of ABC transporter specific for carboxylic amino acids, glutamine and asparagine. The BZtA domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.47416e-89
NZ_CP045178.1|WP_077966815.1|4881083_4882127_+|aspartate-semialdehyde-dehydrogenase	gnl|CDD|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	7.68361e-146
NZ_CP045178.1|WP_107502760.1|4877054_4877504_+|methylmalonyl-CoA-mutase	gnl|CDD|239023	cd02072, Glm_B12_BD, B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'-desoxyadenosyl radical, which is generated by the homolytic cleavage of the organometallic bond of the cofactor B12. Glm is a heterotetrameric molecule consisting of two alpha and two epsilon polypeptide chains.	1.02279e-11
NZ_CP045178.1|WP_077966771.1|4784857_4788172_-|AAA-family-ATPase	gnl|CDD|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	6.31199e-83
NZ_CP045178.1|WP_077966772.1|4788520_4789891_+|S8-family-serine-peptidase	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	4.70616e-49
NZ_CP045178.1|WP_077966777.1|4798233_4798566_+|WXG100-family-type-VII-secretion-target	gnl|CDD|377587	pfam06013, WXG100, Proteins of 100 residues with WXG. ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. homologs have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the pfam01580 domains in the YukA-like proteins.	9.09069e-06
NZ_CP045178.1|WP_077966813.1|4880085_4881087_+|DMT-family-transporter	gnl|CDD|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	8.14716e-20
NZ_CP045178.1|WP_143621193.1|4848942_4867704_+|lonely-Cys-domain-containing-protein	gnl|CDD|380151	NF012197, lonely_Cys, lonely Cys domain-containing protein. This model describes an unusual domain, over 700 amino acids long, that is largely restricted to the Streptomyces (prodigious producers of natural products) and that may occur ten or more times in giant proteins. The most striking feature is an extremely low cysteine composition, one residue per domain, and that in an essentially invariant position.	0
NZ_CP045178.1|WP_107502754.1|4868937_4873284_+|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	3.66624e-16
NZ_CP045178.1|WP_077966773.1|4790370_4794333_-|type-VII-secretion-protein-EccCa	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP045178.1|WP_143621196.1|4873316_4874963_+|hypothetical-protein	gnl|CDD|366226	pfam00652, Ricin_B_lectin, Ricin-type beta-trefoil lectin domain.	1.06405e-17
NZ_CP045178.1|WP_077966774.1|4794683_4796084_+|type-VII-secretion-integral-membrane-protein-EccD	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	3.06026e-41
NZ_CP045178.1|WP_077966800.1|4875773_4876673_+|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	8.76794e-52
NZ_CP045178.1|WP_077966794.1|4802779_4803244_+|YbaB/EbfC-family-nucleoid-associated-protein	gnl|CDD|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	3.06605e-08
NZ_CP045178.1|WP_077966775.1|4796100_4797699_+|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	3.05128e-120
NZ_CP045178.1|WP_077966811.1|4877518_4878874_+|methylaspartate-mutase	gnl|CDD|238149	cd00245, Glm_e, Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate. The first step in the catalysis is a homolytic cleavage of the Co-C bond of the coenzyme B12 cofactor to generate a 5'-deoxyadenosyl radical. This radical then initiates the rearrangement reaction. C. cochlearium Glm is a sigma2epsilon2 heterotetramer. Glm plays a role in glutamate fermentation in Clostridium sp. and in members of the family Enterobacteriaceae, and in the synthesis of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis. S. tendae Tu901 glutamate mutase-like proteins NikU and NIkV participate in the synthesis of the peptidyl nucleoside antibiotic nikkomycin. NikU and NikV proteins have sequence similarity to Clostridium Glm sigma and epsilon components respectively, and may catalyze the rearrangement of 2-oxoglutaric acid to 2-keto-3-methylsuccinic acid during nikkomycin synthesis.	5.12037e-156

Protein sequences

>NZ_CP045178.1|WP_077966795.1|4803240_4803657_+|hypothetical-protein
MSAGGTYNGNPHEVQQVSDSLHSVADAPAKMIDQFRMESTYYDEWNGQEDASADDFKKQTEPDWKNAKDAPVRFLQELGGAVSGLASALAKQADSMIGTKGFADDLIHDAMSDTESLDLSDGDSGYGSDGDTAGGGRH
>NZ_CP045178.1|WP_077966794.1|4802779_4803244_+|YbaB/EbfC-family-nucleoid-associated-protein
MTEPMAERMAKARAHLEETQAAIARAEQDLRNTSERVRSRDRAVEVTVGPQGELTGLTFPDNKFASMTGPQLAASVLEASDEGRRRVAERVMETFAPLTGPNPYVPESRGVEMDWEKIFGSALSGGRQGGGRSSDRLRDEIDEDDIDSAPGGRA
>NZ_CP045178.1|WP_077966787.1|4798724_4799225_+|type-VII-secretion-system-associated-protein
MSDGGKTIVLNKEWMKSFINGDLHDFQSAIAKMLVSAPSERFGSNMDGVDVVSITKLQDAPDNIHSNNQHPLAIGALAGKDGLGADLVKSILDAAGKLGDFIEDQKKLFDDIESNLRDTMETFLKTEGDSMDKIDGEKFLDVFEDVEEDIADSLSGGGGGGGGGDE
>NZ_CP045178.1|WP_077966777.1|4798233_4798566_+|WXG100-family-type-VII-secretion-target
MSRAVPNFEDGNIFVDFTSTDYAIDDMQMQTNQIKSWLDALAQELDHLDASWVGDDAVVYKEKQTAWNSAADQMGALLASHASTLGDVTHAFDENQKRSAQGWSSLKIGR
>NZ_CP045178.1|WP_077966776.1|4797799_4798129_+|hypothetical-protein
MGKLTQQEEDATRKGINALEQAFAGVQRSRQELENTKNNVGMGGDVGRNYIGLLDKWDDQAEIISKNLREMINELNNTLQQSGLTRGSANDAVNTAYHKSESIFNALAG
>NZ_CP045178.1|WP_077966775.1|4796100_4797699_+|type-VII-secretion-protein-EccB
MQDRRDQVQAHMFTMGRLTSGMLRADPDAPESPQGRTNRGIAISVLIAILICAGAFVFGLLKPGTKSSWRDPGTLVVNKDTGTRYLYLGGRLRPVRNYTSAKLLAGDEMTVMSIGGKSLAGTPHGAPVGIPGAPDEAPATGDLDTGPWQVCSGTTTGSIGTTVAVGTEPDGPGLKKEQGLLVTGPDKADYLVWQGRKLRLDETAHAAEALGYGAEQPVKVSAALLNSLPSGPDLTPPEVSGLGEPGKELAGRQTRIGEIYKVTASGAKARYFQLHKEGLAPVTATGAALVLGDPETKQKTYDGGSTAARSLGTDELNGNLAKESELTDRTEGMPEAPPEPVDLESGQTPCVGVRAGGDGTRVSVALTDPADLGPTAQAPTEGLTPACVTVNRIAVRPGRGSLVHALGAGGSDVGATLYLVTDTGMKYRLPSQEGLKALGYTETRAQGLPSSLLSMIPTGPDLTPEAATTGHAKTTAPKCGNERETTEDQRQGNAATTVVSSSSNGSHTVGPVNSLHRFDPQPVVLQKGLTGF
>NZ_CP045178.1|WP_077966774.1|4794683_4796084_+|type-VII-secretion-integral-membrane-protein-EccD
MSDTQTAGLCRLTVRAPSRSIDLAVPSDVPVADLLPAVVGYGGDDLQEAGIDHGGWVLQRLGGEPLDEERTLDSYDLRDGETLYLRPRVDALPEVHLDDLVDGISTTMADSPYGWTPKASRRLLRGFAVLVLFGGLAILALPGDSAAIRAVCAAVVALLLIAGGGSASRAVGDAAAGAALGVMAAPYLALAGWLLTGGEMSGPDAHQVIGARLLAACAAGAGGAIVVLAAVTAFAALFLGVAVVAVFGALAGTLMLTADLAPHQVAGIVALVAVVLGAFVPSLSFRMSGLRMPPLPTNAQQLQEGIEPHSPSGVAARAILADGWMSSLYGAVGTVCAACLGVLAWYEDLAATFMVVALSLLLLLHSRGLGNTWQRLSLAVPGALGPLLLILMVAFDYAPGKRPLLVAALLALTAAVAIASWTVPGARLVPYWGRLGEILHTLAAVSLLPLALWVLGVYGALRGLMA
>NZ_CP045178.1|WP_077966773.1|4790370_4794333_-|type-VII-secretion-protein-EccCa
MVLFRRPARRRGPDMPEGELTLQEPPTLPEVVPDSSAVWTYLPMAMMSVSMMLMFMRPGMSGASGGHFMYLAVGMMVLASGAMMVGQMMRKASERKQRLKGERRDYLRYLTQTRRKVRTAVSDQQKALSWRHPEPAALWSMVGTTRLWERRPQNEDFGEVRVAVGDQQLGLRLVPNSTTPVEDLEPLSAHALRSFIRAYATVPEQPIAIYLRAWARVLMRGDEERMRSLTRAMVAQLATFHAPDDMWIALCVSDERRAEWEWVKWLPHNLHPQETDGAGHARMFVSAFNELEDLLGAEFLERPPFDPDAAAGREEPFTVIVLDGGAVPSGHRLDGTGFRNTVVIDLGGALTWRPGRVTLRFQVSEDDFALVRTDRDRKEQTTRLGRPDRFGPTGSTALAKRIAPYRMGVGSDTSAPLASDLELTTLLGISDLYRHEPHAHWQRSTGPARLRVPIAVSADGAPVELDIKESAQGGTGPHGMLIGATGSGKSELLRTLVLALALNNSSETLNFVLVDFKGGATFLGLDELPHTSAVITNLAGEATLVGRMQDALHGELMRRQELLRSAGNYTSALDYERARATGVPLAPLPSLFVVVDEFSELLAAHREFMELFVMIGRLGRSLGVHLLLASQRLDEGRMHQLESHLSYRIGLRTFSAMESRGVLGVPDAYQLPPQPGAGYLKSGVEALTRFRAAYVSGPYQERRSSANKARVASQTVPWTSGYVVPRQLPDLPEPEPEEEEESVDTLLSVAVDRLRDAGPPAHQVWLPPLDRPATLDQILPPLVPDPEMGLTTVGWPGRGKLTVPIGIVDRPFEQMRDLLTIDLSGSGGHVAIAGGPQSGKSTLVRTLITALAVTHTPREVSFFCLDFGGGTLAALAELPHTAGVAARLESERVSRTVAEITSLLSARERFFLEHGIDSMPTFRRRRAAGEFPEQHYGDVFLVIDGWPTVRADYDNFIQTFNGIASRGLNYGVHIIVTTSRWVELSAGVRDQAATHLELRMGDAMDSEIDTRRASTVPRVPGRGLTRDGKLHYLGALPRIDGMESAEDLADGVSGLVSALKESWPGPQTPQVRMLPTKLPVERLPAPEGSLRMPIGLEEKELSVVWHDFTENPHLFAVGDTESGKTNLLRLTAKAIMDRYTPAEARIMVVDYRRDLIEAIPDEYRLGHAVSIDALKDLVDGAARAVRTRLPGEEITPARMRLCDWWTGPRLFILVDDYDMLGTGIGNAPFDPLLPHLALGYEVGLHLVVTRSATGASRGLSEHLMRRLQEVNTPSLLLSCPPTEGYLIGNIKGRTMAPGRATHVVRRKATQVQTAMVDDGK
>NZ_CP045178.1|WP_077966772.1|4788520_4789891_+|S8-family-serine-peptidase
MRRAAPSHRHPVPRAVAAAVLAALTLAAGAGQAAAADVQLPAVTSVLPAGEPCAKASTDKAEQRPWSWQPLGMTKAWQFSEGAGVTVAVVDTGVGTDIPALSGRVQAVGGAGEDCVGHGSFAAGLIAAAPGKGVGVAGLAPRADILAIRGTDTRGETTPQQLAAGIRTAADQGAGVIYVGRAVATGKDELTEAVAYASEKDSLVVAPNVPDFLPKDSGTGKTVAPAPWYWPGAAPGALSVVDYGPGGQRPETAPPAHNADLSAPGDAVVSVGPTGSGHYFGSGSSFAAAHVAGAAALVRARHPKMSAEDVARQLTVAGYPEEPPRLDPYGALTALLTDKQGAPPKEAAAHVPPATPTAPRNRALVIASAGGGLLLLVAGGTVVIPRGRARGWRPGGVDGADGVDGAGGAPVGAPKGEASGSGEGTGPGEGSGSGEGSGPGEGSGSGEGKRPSGQAG
>NZ_CP045178.1|WP_077966771.1|4784857_4788172_-|AAA-family-ATPase
MSRQLLRVDPDGTDTFPTIGEALAQARTGAVIRVKPGRYRENLTVKTRLTIVADGERGSVEICPPRGTAVVLVADAVMLTDLVLRGGSEDLPVVDAPRGQVAMDGCTVVGSGWTAILARESGSLAMRGCRVSNPQGAGVVDTSSAESVVADCLIEHLGTSAVVLGEQARTTVRGCRMRDAKGNGVLANGEAQGRIEECDISGTEKPAIALEGRCGTRVVRTTLHDTSVGVYVTSSSRPSLEDVTITDTSGPGIVLSAGADPELLRCTTARTKGNGLAVTERARGTFDGCEFNTAAVAAIRVNGSSAPLLTDTTVRGCADKAGSVLLTEESSAEFDRMEVLDAVGVGVSIRTGADPLLRRARIIGAGGHGVEVLEDGRGRLHDCTVDGAGGAGVYVGNGGAPEVADGVLRAAGQAGVWVGPEGRATLRDCHIDGGSATGLHVDSGGEMTATRTHVTGASAHGVLIANGGRATMDSCQVSGCTGDGVRVDSSEQVALDDCAVRDNRGSGLKQTRASERLTVERLISSGNSVEDAWGETAVDLAAEGAATESGAKEPQGPLVELESLVGLGDVKHQVRTLINLNQLAQRRASLGMPAPPMSRHLAFSGPPGTGKTTVARLYGGILADLGVLPSGHLVEVSRADLVAQVIGGTAIKTTDAFNEAIGGVLFVDEAYTLLSDSKGSGADFGKEAIDTLLKLMEDHRDDVVVIVAGYTDEIGLFLSSNPGLASRFTRTIEFANYSVAELVTITENMCAAHRYELHPSTLDALARHYERMPRDAGFGNGRAARQVFEEMVDRQAYRLGSQPDPAWTDLSLLLPEDVADESAAGQTEDGRGADELLAELDAMVGLHAVKREVTDLVTLLSATRQRQAVGLPTPKISHHLVFEGPPGTGKTTIARLYADLLHSLGVLRTGQLVEVARADLVGRYVGHTAQLTKEAFESAMGGVLFIDEAYALTPENAGSDFGREAVDTLLKLMEDHRDEVVVIAAGYTEEMHRFLASNPGLASRFARSVKFENYSSDELVAIMNSYATASGYDCAPETLEALRTYVSHLPRDRSFGNARTARKTLESMMTRQARRIGTITTPSVDDLRSLLPADLPEGAGLAAG
>NZ_CP045178.1|WP_143621193.1|4848942_4867704_+|lonely-Cys-domain-containing-protein
MSEATASSSAGRAAAGPAPVTYVSFPPRGATLPMRDRATVRNLVSQVAALGMRARELRLPLPPVTIRTYDEVTPGRQPLEGPRAREVYDEFTRGLSEELSWLQRNLPPGRPRLRAEHFGIAVKPRKGNAAPTVVPAGGSTRTPTRAQGSVHVSLPPRLEFMEGLDALRRRDTRLREGDFDLAALARQVLHLDEAARVDDAVRADLFDLVERARAAGFGHSVAAFGAFHLQELGVLAADRERHLAVDGARVPGLNWTSEKVRNLELGAFRIRRAREDGSLSSPVSLPTSPTHTPPYVVAADEGRHDRVSVRLPDDSSRELDIEEFVELVAADVRRAGLPRGTEIVLAFPFAGDRTLKLPRLLADRTGLTVWAHSGVATLADAEDGKSRIQVTHRHLKQQGDWVPNPPGMAPGPDPEDPRDWSLRVFTRAIISAFTGKQIGRGLHKETAVTLEDHGRHLDRMTTYVHHNPATGKNSVEHAMPNPEPGPGEPPFGDPYFLDAHAVPGAVQVTLDDGSRERVKIRPFFQWLGRRMSFSTRPVRDWLDLVLCYSGSAPDGSVRPLAPGNSFSGSFVADPLAVISLGQEAANTTGRVTRVSYLKQSTNRRRAGKYVRGLYRDAQGRLAWWDIYRPEPSEAELDRLARVVGWHTGTDDPADDVRLRTLRAVRALRLVFGYQAEFEPDHEELMRGIAALDDMWRTDGRFDKLGPFTMDLLWRVVAAHPAGESEDQGVAALRAVLTEARAAAPGTRLEDFVSLPAVDEALVWAGQQDMDVTAARVLKLSGPEETGDAERSRMFWARVKTAEALATPGVDIGRTTARLLHLSAETTDDTTLHDTMRDLSTMVFAEGREVTSPDVMGARHLETMGALTEETALRTVRGTQKGGGRDFTGGAKPSRVDLSQVHTPDGLQEAPWLEDDNGEGLPTPYLVRAELDYTDPDFAFLNLDGDMERVRVGELVELLAHDPRLHGQGLNTSVILAMSGLGLLAPDLAQQVAQRLGRSVWWTDFRVSTSEKGDSGHPVVTLHADPGTGSPQDDGWQVAQPADPHPSEELPRPGGPFFERSGDPVTDEGEGGDPVPATGEAAEHTAGEALDAPARSAEPITPTTGTGDRHAPRDDGGPRAEARTRSRARKPAKSSSGQPMPGVGAAGAATRLPIRPVSEPVGSAPLPELPKATPVPVVRQGRTSAGSGADPIGGLAVAVARSGLRNHALNVSLPEITVVGHGEDGARGSGTRTAQPTGDQDTRSTREEFVRRLDAELRAAQRRLPEGERRLTAADFTITRRERTAPTEPTRVSEHERVRAARRRGPASGEGRLRATLEITQRPDATAVEFLDVLRAGDRRLDGKPLDVAALTRQVLHLGEGAVVDAAARRNFFGLVERARAAGRNRGFAALAAFHLEERGLLAADRKRHLTRDGKRAPGLNWTANEVVALDTASGYALKDDEKGAVDRTGPHPFPWSKGPRPYVVAAEGRFDRVLLRLPDDSEVEVGIEELVELVAADVARQSLPAGTGIVLAFPFAGDGWLDLPRLLADRTGTTVWSHIGEVALTEQPDSTTTMDEVFRLGAAAGTWLPTPPGLGLDPRDGDPLAEFRDVRTQAIVSKRTGRQIGRSSHNLADLVENEFEEGSRHLDQITTFVHLHPLSGVVSPSHPLEGPGDAADAFYEDTHGNLGHVGLANLDGSTRKMSEQSSMRRWYRRMSVLVNPKRWLDIGACMGANQDDMALPARKRMYSHMEGVFVADPLKYVPYGQRAANAARLPVRAATRAQVTDQLDGSYTRGLLSDAWGRHARWVYYLPEPEDAELDLLAAQVGWHTGRGGASAEVRERTLRAVRALRLTFGWNVEQEYSATGGRSAESGYLGLLRGVAALDDMWRADSRFAGLGPLTMDLLRRVVETRPEGGKGARQAAYAEVLGKARTAAPGTRLADFVTLPAVDEAVAWTKRADLDRAAVDALLLGSTDQVGTEQRSRMFWARVKAEEVLAAPGLDFDQLVARVLHRPLTPGIGANAGMRRELWSVFTTAFAAGRAGSDPAVAAAHYLERLDALDLDSVMETTRGADTGAGRDFGPWPGPYLVDLDQIRTPAGLADVTWESWTYAGTEKPHPYLIRTALDPQDPEMVEVAIKNNTYRTRLDSYLELLLADHTLMEDENLPVLLVLEQGLLTPELAQRIADRLARTVFWTSVPADLSGTNDKGQAVLTLKDGPSGTPAPSAAAIRKTEPVSPAAPGESRLDVPPPVPRSTGREETVRSTGREETVRSTGRTAVPATEPKAVLSAERAAVRAALGPVSAADVFAADVFDDDTDIDTDTDTEAATGTGTEAVTRNGTEAHASEAGAPVRVKDRAGDRSSDRASLSSEASATSDEGTSTESEPDSPSEVSDDETFFASGDEISFSFASDDELSSDSDSDSDSDDETDATRPVSWEPDVARPASEEPAPDQVPSGPGARADAAGRRLFRGPGTDSSSDESDESDDSDDSDDSDAPESAMRRTPGPRGVYTLPVRGQLPASPDRALVEWLDELREEDPKLSNESPADLARRVLHLDRTEAVDDEVRAELYALAGRARAAGPVAGVGALAAFHLRELGLLAADRKRHFTVGGKRVPGLNWTGKEVRQLSLDTVAVTKERKNGSLDAQRPVRARWPKSTLPYVVAADEGRHDMVVVRLPDGSSLEVDIEEFVELVAADVRDAGLPRGTAIVLAFPFAGDRLLSLPRKLADLTGLTVWAHSGVAKLADRDGGASGLELTYPFGKPQGDWIESPPGLAPDPDDEVDEDLEGWSPRMLTRAIISALTGKQIGRSAHTDEELADWVEDHGRHLDRMKTYVHINPASWTKSAEQPIPEPVPGPDEEPLGDPYYLDMHGILGYGKFPMENGRSRQEPHTGVVGWLKRRMSLASRPARDWLDLVFCYSGSPDDSALPRSGSTPASPGAFVADPLSEVSLGQLAANGTRRLTRSSYLPQATHGPYDNGKYRRELATDAQGRRGWWEISRPEPLAAELDRLAKVIGMRTGSDRTAEQVRERTLRLVRALRLTFGYRAEFEPDHEELLSGVAALERMWHADGRFTALGPFTMDLFRRVVAAHPDGGTDPDKAAFRAVLAAARSAAPGTRLRDFVRLPALDEALAWARDVDLEEEAARALQLSSSNDVTDVQRSRMFWARVKTVEALTAPGVDLDRVTAQVLHLDEETTDDEDAHAFLWSFYTWVFARRGEVTGADLVAAQHLETVGALGSSTTLTTSMDGEAEKGRDFTDAPVPAKLELSRIRTPDGLAEAPWAKDGADSPAPYLVRVKLDERYPGSVIATIDDTEARVTLGELAELLANDRVLQKQGLSTPLALATNLGRLAPDLSDTLSRRLGRKVWWTDFPVDMSGKDDTGTAVLTLHPDPDTGARPQDTGWKLTEPVDPAAETTLPRSAGPLLTRSGRAAEGTRATDRDRQDLARHGGEVTDTTVAHTTVPGTTSARTELSGTTPSSTTPADPTRPVPDDGSGERLAANPDPDPDSDPDSDSDFYSDFYSDAGSDRDSDAGSDSDSDAGYDTASDSGYETGSDEGDFSPIVDDFGRGHRGLQGSVHVMPFSDETLKWLHVALGRAVHHQAGLAEPAARGEQTDDALGEPDLEAQTIDAEELAALGRQVSEAYEGSSLLEDLPYVLSGKGMVRTVTYRGREYRISARLSLSDATPAPTMASEVSEGRKVHIEERNRSTISSADTSGTSTVRSLPLSYGRTWLVPGSANPVLAYLASLGITPKLTFTHNQVATSLTVEEDFTAVSALAFGSGPSRVFDYAMEWQVKAEPADGVTPTPALSTPPSTAPAPAPTAVPDPAGTTDPATDPATDPATDPATDRTAPTDGWGAPATSPGRVTAWFPDYLNEKPEPTPFGSLFSSPSDLPAEPRMVTEEQPLLRMDTIRDPAALHDGIVASDELRPHLRRMSKESAEELREFLSENNQRSGLPLMLAGAYPSPVLLDRAGDPLGYVEVRARLKWLSPEVLAKSRNVVMESSLLHTVGPKASHTVSNAVKPGFSFAPAFENPDGSGVGGGPTFSGSYQYQRDRVLNSGGTAFDWFGLVTENPHLLVEADIEFEAVMVLADGGRSEPYTLDRPAGQLLRVPSRADADGVPVEEGQERHLPSEMAELRSLGMSATPLRITGTDEVFAELETWLREHNFLPPNHRYSLSWMDDRSRRKIQGAWLANSRKLSLARTQVGLRSGLRQMVDGGHPLHFDLPFEHDVWRASMVLTVEPQEGTYPHHRKNLPGWSSLSANGMSASAGESYTSSHTLTGEFAGEAHGPVSANRTMKGGVPSSVSASGQRVHTAGSSSGAGLDAIMFNQSGLGVYDIPGTFKARIFSGQGTEPVRTLTPRNGNISLTVPLARTLDARPEPLPAPTSRPATDDDYRLARLEPDEDGDRPREAQMLPAAAHVNMAMGSAELIKAFQQLLAGGHPDGNPDPGALARILNWTATHGAQVGLALPSLVTQPSQWLKDITLGESLTLPEGPAQEVGRSALSSTVVHARAHQILRGAYVFDVGTAGSLLGTDAQGEVRGYLHEVVHEGTGFRPEEFAGTENWIESDITATDSSWRGTGSKRTVQIAFSGSGTLTDQDTSGTVSGSAGRSFSAARSETDTDAVFTNRMNVEAREPIHAFRADITYVFALAKGYRNAPANAVGFGPLGTRAIAVRVPGGVIFWVAETDVKEDPRLAELAGLTPSLPKLDRLLPPYFVRSRGRALGPASVPDVVPNGPLDSYVDAIRTAVGHEADGVLTPGSGTHVPGLDSLIVDAGSIIGLRTLAGAGAEKWRRIHFVHQESTVLYLVEVALNARPAPDRDLSEVRGALRPKSGMENQYSSAPTSVTRTATRTGTFTLGLTGSAGYTVAPGTDNTGSAGAAASFASASSKAVSHILTRNRQQWLRTYAPSAQFTVEYEFRVGVSSTRLDDSVPGFLINRLVTAGQVAELIGRGALSLSETTGLTRLLSRMVGGVTGEVSRLLRQAPGSPETEAEETALSDPATAPGTAIPLVPVTALDARPADAARPDVDAESDLVAGDTPPAPGTAISSTPVSVKLRFPTGDTPQELEDGTVEWPDAPELLAPAVHETDPRATEDHPLVDQATDQATDPDTAAAPETAANPLNGTALWTPEQTLVIGDFDATGELADALRAVDPALRDKALPKASGSQEATLIRIGNLVRSGRVALTPAQASRYTERRASAGSSAIKLTFYRPQTETSGRAVTLMGMRTDVRSSSTAGSQTATPIVNVPLSGGMTTGDTDTLSGTIPVAGENISTGQTTGVTSFRREMIKYGTGLSQTDEGEPDDSGVLGFTLTVHTVLEVSGPEGTRWVTGNAVVRATLEDVLGLGLAPARPSPGVYDAPAAVAAHAAQNTAAEEAPDEAAGDWRGLTPEEFGDRVAAAFTDEDESPQVWLDPGDVSTAARRALLIARHTLTDGGTLAEARRAAGTALPTDLAAAMGAAAHAADRARRPVELVLRTPAGPVHLPFTPPAGPDTTTTPPVPAPPVSPAPSDNADDSEGSRSPEPPEPPSTPPPSGPPLAPESFGRPKSPEGSERPVRREPSEQSERREQPKQSVRREPSEQPVRSGSAELSESRKVTPPVERQVSPDLAERSAPAERPQRSEPTVRPEPSTAPAPPLPPVPPTQETVAPPAPENEPEPAPEPAPKPEPTPALTTPALPTPVPEIIVTPPEEDVRAGEALGRAALHLTQDTVWDARKYIESRELQERAAATGQDPADPAVLALLHLDRLGAFSDATRILDAEGNHQGRNYGSAPTPGGIEPLRMYTVRPGPGGNTTELGFAPWAAHGGPPPYFVHTDAGDITDAEGLTDADGVTGTRGTTGAEGSTGVNVLRLPGGTVSVSDAELFALVSADPALRGADRDRWVAWLSAGPSTEARRAEQQAYSDRENRTAVSYSATVVLSEGDPSEPSWLTALPDRTTGAAGRWHSARPSGEGRGSPARIPSTVPYTADGRFDESFEGTRKMFPTPVVTSTGRSTVWGQGQHDPEHHVFVAELPGLGLRGEYNPYGPSTGRVTDAEGRLYSEGPAWDWYLAGRGLVASSRLRTVLLAHDVDGDPNDSGVLPVPVAWPATGPVSATPPVDPATVAAVPSLLLLLNDLLAAFRWRDHTGPLYIFSSQSPQRIFEEGVRPDGDQWIHPIDHVYGDDRSGSAWVTATANLSTDPARGSGWRVDLGAPGGVDVNATLGLASPLPGGWEVLFPAGVHRRWIQGAQWLENGVPVGDYLPNPHFGEDADDNPQKTPEQHDPGTSTSK
>NZ_CP045178.1|WP_107502753.1|4867711_4868554_+|type-VII-secretion-system-associated-protein
MSETSGEARAVADPAEPVLDDGAATATVDPAPPEEFIEAAKLAPDHWLYLIDPTWSDEGPPPEWAVVGQWRSDAEGEIVEWQDNEDYRPSPASMGWPDPADEVDAAIQLATTGYGPADDVTKALANAEVAVLVTADGDPVRASAPDSTPVVLVYSSPKYLHLAGRLAFETTKVPEFLDRIPEGHSMCINSSGPVSMVMTTDGLADIMTAAQEAPEGEEEQSPSAARSVWPQQTMSTEPAAGAESASASSSVESGTESASAASEPASVSEPGQDTAAGEGR
>NZ_CP045178.1|WP_107502754.1|4868937_4873284_+|hypothetical-protein
MSRSDSGRARWFGRKGSRTAAADPVTTPAAPSAALPAGGLRPGSEDIEEYVTGGGPEPLLVEEYDGIRLLRTPSDEALSNSDVLDLVRSFAAEEDTVTVVAGVDAPQSADLWPRLGGLLDDARQDGVSTVRLVMDAAGDDRPGAPALARRIADAWKLEVIAPDGTALVVPGGGLFVFARRPENGARAAGDTFAPRGGWWRFPPDAEREWAGVRQPTPSWQSALDRLPARMAGGCVIEQIPAGVLARSRDSAPPRPGDLCYAVPADPRGPTVLVGVPQGEDVTASDIVEVLSALPETVREQVRLAPGSTRDILRVGQSVSDTLGSEVVVYTGMPLLSPGTETRPSKVRAVLVGADGEPRWEAYVGAVMCLPTKVGEPARAPQPLRWSLPVAAPRKSGGAPPEQGLFPLSRQWQASVTRAGLWITDVSDGRPPTAVRQVDPEGPAIEVGRPGQSLEPSLYPALGKLLGGLGTEVRGKARLLVHGTSTDGGRELRRIAAEHGLRAIRFSTSLAARQAAAAGGSAHSSIPGPTAAGPGPGVPAAPARGRSGGTAARPVEGDNGSPAPTVSRPTPAVPTASTPSTPLSGTGSGTGSGTGTGSAGGNAANTSSPARTSHPPHPANAPGAAATGTSGDQEASPPAFRRPSASWDSEGPGTPVSEPDAISRALMGEADQDSWRGSGFGPTPLPSVVPSAFRPMEPAGPGEPLRPTDPAEPMRPAEPAEPMRPADSAERLRPVEPAEPLRPADPAEPMRPAEPAEPLRAADSAERLRPADPAEHVRPAKPLKPAEFAEPAELAEPAVFPVLSPAVERTTEPEEPQLPAARPSGAGPSDGDPLGANPSGANPSGTNPPGTGPSSTGPSSTDLSDGDPSGIDLSGGDPSSIDQSGRDPSSIDQSGRDPWGTGPSGGPLTPWSVPGVSGAEARGQRPARTGSESTASADRVTPPNATTRGPAAADSAAADSATPGAVTPDLATPGSAALDSAAADSVTPDPVTPDPVTPDPVTPGKVIADPAGPGSAAPAPVPPHPIVPPLGGRSGETPDSGTLRAPSPEPEHEHAPPPDPATRLHLPTEPEAPEAPEAPEAPKAPKAPEAPKAPEAPEPPKAPKAPEPPTTPVAEAPAPCPASPVSTSTSTSMSTSTSMSAEFAVPEPPEAPQRPKAPAPPTSAPVPSGPRPHAVFTAGPLPPVPFLPGYASSPAERTAFRGLAEVGWEQHGAAVMRALTRMPALRGTELEEARADLIALHMYLHATEGPLSHAELSRSLRDGEEELLPYAACVTSALRRLPSYRGLAFRGTDEADVGLVPGNLLRDATPVGALPLGAGAPRPGGAQYAIWSATGRRVRELATGPGASSGRDEIVFAPGSLLRVLDVRESDGAPMVLLREVPTSAATATTGTVPQSTELDDHDRAALDRLDQALRRHPLAPGPFGWPELCRGPLGRRGDAAGAVPGSVR
>NZ_CP045178.1|WP_143621196.1|4873316_4874963_+|hypothetical-protein
MPNKEPTGQEGPVVRRAVPLPGSAGPPDPDVLPKQGGAPNGSSPATTSGETPGLPTPPASFGPTSSAGSEGLSGSGASSKEKEGEGGASGPEPVKGAAGSVPGPEAGPGTDPETAPDPDPDTDPETDPTSDPTASGKEGASEATTVVTPTSLPTPMPKSGSALTPAAQSSAPAVKNSLAQSAKASTSSAHTAEPTVSPTASAHGGPGAGAAGATATASASGGNPPEASTAAGADGTPPSGRPTKALRAAAAIAGALLIAVPLLVLGSGDDDDKKKTEAAAAGMTIPKGDEVAAEGSYKGKSPSPSASAKKDEDAKGAKDAKGEKDEDSKDAGTEPDESAKGSDAKANGGSGAAKEQSSKDEDKKEPETKTKTKTKAKTNTVARLTTGVGSTWAARKQIRNVMTGMCADVPGYGKGKIEGQVHQFPCADPRSSDNQTWDIVRKHKGKAPNGSDLFVIRNSTDGLCMDLPGSGGVPGATGIQEYTCDGGLDDNQLFWLDGKGGGKWWIRNYASDNMCLDVWGKTFGSGGSAARLGLANCYPKDDHMWRFT
>NZ_CP045178.1|WP_077966800.1|4875773_4876673_+|LysR-family-transcriptional-regulator
MDIRQLRTFHRVAALGSFTRAAAELNYAQSSVTAQIKSLEVSLGSELFERVAGKVKLSPAGTRLLPYAGQMLTLADEARGVASPDAQPEGVLTIGTMESITSYRMPTVLEFFHHRYPRLQLALRPSLCAETLHSLRQGVFDAGFLMEAETQHSGVQSEVLGVEPMALVAAPGHRLASEVKVATEDLRRESVLAPEAGCAYRELLEAELNDGSGEPVPFLEFGNIEAIKRGVGAGLGISLLPRMAVAAEVASGALTQLAWETPFVLYTQLAWRRGSQLSRERQVFVEQVIDFLSHEYREG
>NZ_CP045178.1|WP_107502760.1|4877054_4877504_+|methylmalonyl-CoA-mutase
MLPAKRFVVSSVSSDAHMWNLVFLQLLLEEQGADVTNLGACVPDDLIIEECLRTQPDALVISTVNGHGHLDGLRLIRRIRSVPELADLRVVIGGKLGVRGADNIVFAEELSLSGYDAVFEAQGGMDGFQEFLGALDSASRPELTSGVAA
>NZ_CP045178.1|WP_077966811.1|4877518_4878874_+|methylaspartate-mutase
MTGSETGVAPRAGSDVTPRGRFSRHVREAHAQGRLVVQPRMGFADLATMREGLIQAREADAATIGTVTLDSYTRVNDHDSARQALRTGAELNGFPLVAHGSSATRDMLDSVERSDFPVQVRHGSALPLPLFRAMVEADVAATEGGPISYCLPYSRAPISEAVKAWAACCELIAEQPDPMHLESFGGCMLGQLCPPSLLVALSVLETLFFREHGLSDVSLSYAQQTHPGQDLEAIAALRRLGAERLGGADWHVVLYTFMGVFPRTPVGSFRILEESVRLAVRSGSERLIVKTPAEAHRIPTIAENVDALEFAASIDRDERQRPPEVEATESGIYEEARMLIDSTLELAPTVGEALIKAFSQGHLDVPYCLHQDNSNKSRAYVDAGGMLQWAEAGLMPLRVERGGSRRPVTAKGLLTMLGFNEQRFDREQLTHGHLRSVQYTPPPRPAAQILS
>NZ_CP045178.1|WP_107502761.1|4879100_4879985_+|transporter-substrate-binding-domain-containing-protein
MVSRGIRGLSLRGEDGRWTGLDTDIARAVAAAALGDGEAVEWVPSDPADRLTTLVGGEAELTVCNLSWTLGREATLPVLFAGVTCYDGEGFLVRADSGITTPQQLAGHRVAVQAGTTSAANLAAWYGSRGLSVEPVAHPTPAETLAGYADGGCVAYVLDRVALAGERAALEDPGAHLILDEAISREPMAAAVRDGDASWYKLCRWVLQLLVSAEHHVDEVGEREKALAQAAETAGVHGPAVGLDTDWAARVLDAVGTYADVYARNLGPATGLDVPRGLNELWTKGGLHYALPLH
>NZ_CP045178.1|WP_077966813.1|4880085_4881087_+|DMT-family-transporter
MTTETKPANQEKKGAIELTAAMVLSGTLGVFVIESGASPFNVVFFRCLFGTITLGLYCLVRGFFKNHNFTPKKLGLAALGGVFIVFNWAFLFESYEGTSISVATVVYHTQPFYVVLLGALLFRDKLTATKFGWLGVAFIGLILVAGVSASDLTGGGDTAYLQGLGYALLAAVFYAISTVITKRVTGVKPHLVALVQLVLGIFLLLPFTALSEMKNMGGDWGWLVGLGVIHTCVMYVLMYSAYQKLPTPKIAVLAFVYPAVAMLMDWAVYGHSVSWLQALGIPLIVAASLGINLGWSFKGRRPAAVQQAAPKAPAAGSTTTTESKIEVQSGGNR
>NZ_CP045178.1|WP_077966815.1|4881083_4882127_+|aspartate-semialdehyde-dehydrogenase
MTLVTDTKAPRIAIVGATGAVGNTLIGLIESRGLRYRSVHLVASARSAGTELTVDGVAYPVQAVDEFDFGQVDLAFFSAGTEASEQWVPKATEAGAVVIDNTIAYRMDPDTPLVVPQVNAHELDERPKSGVIANPNCSTIPLVRLLQGVERRWGIRQAVVSTYQAASGLGHPGVDELKDSSRAALESPGEEYPNKEFTPSLAFNVIPKIDRFLDTGFTLEEQKMLQESRKILGMPHLDVTTTCVRVPVVTGHSEAVWIEAQGVVDRDELVEVLAELPEVTVHDRESRREFPTPTTIDDPYRVHVGRVRVNPNNPRAFWLWLVADNLTIGAALNAIQIAEELIARDTL

Crispr_ID: NZ_CP045178_15

• CRISPR_ID: NZ_CP045178_15
• CRISPR_location: 4894754-4894861
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of NZ_CP045178_15

Consensus_repeat	Method
GAGTCCCAGCCGTACGGTCAAGGCGC	CRISPRCasFinder

spacers of NZ_CP045178_15

>15.1|4894780|56|NZ_CP045178|CRISPRCasFinder
TCGCCGAGTGAGTCCGAGTCCCAGCCGTACGGTCAACGCGCCCGCCGAGTGAGTCC

CRISPR arrays and Neighbor proteins around NZ_CP045178_15

CRISPR arrays

The CRISPR arrays of NZ_CP045178_15

>merge|NZ_CP045178|15|4894754-4894861|CRISPRCasFinder
GAGTCCCAGCCGTACGGTCAAGGCGCTCGCCGAGTGAGTCCGAGTCCCAGCCGTACGGTCAACGCGCCCGCCGAGTGAGTCCGAGTCCCAGCCGTACGGTCAACGCGC

>NZ_CP045178|15|11|4894754-4894861|CRISPRCasFinder
GAGTCCCAGCCGTACGGTCAAGGCGC	TCGCCGAGTGAGTCCGAGTCCCAGCCGTACGGTCAACGCGCCCGCCGAGTGAGTCC
GAGTCCCAGCCGTACGGTCAACGCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077970747.1|4894882_4895458_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
NZ_CP045178.1|WP_077970751.1|4892131_4893322_+|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|235596
NZ_CP045178.1|WP_077970730.1|4901870_4902437_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224584
NZ_CP045178.1|WP_077970752.1|4891360_4892047_+|cysteine-hydrolase	unknown	unknown	gnl|CDD|238245
NZ_CP045178.1|WP_152330786.1|4899380_4899875_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966819.1|4886373_4887129_+|3-isopropylmalate-dehydratase-small-subunit	unknown	unknown	gnl|CDD|179314
NZ_CP045178.1|WP_077966820.1|4887125_4888022_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176102
NZ_CP045178.1|WP_077970728.1|4902462_4903776_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966817.1|4883299_4884337_+|oxygenase	unknown	unknown	gnl|CDD|188461
NZ_CP045178.1|WP_143621410.1|4898179_4898761_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970733.1|4899871_4901116_-|hypothetical-protein	unknown	unknown	gnl|CDD|376749
NZ_CP045178.1|WP_077970753.1|4889208_4891206_-|FAD/NAD(P)-binding-protein	unknown	unknown	gnl|CDD|379196
NZ_CP045178.1|WP_077970768.1|4893434_4894067_+|aldo/keto-reductase	unknown	unknown	gnl|CDD|381304
NZ_CP045178.1|WP_077970731.1|4901118_4901427_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970745.1|4895680_4897147_-|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl|CDD|129794
NZ_CP045178.1|WP_107502762.1|4888077_4888476_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|315619
NZ_CP045178.1|WP_077970736.1|4898757_4899384_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970744.1|4897211_4898105_+|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|223713
NZ_CP045178.1|WP_077966818.1|4884919_4886326_+|3-isopropylmalate-dehydratase-large-subunit	unknown	unknown	gnl|CDD|235490
NZ_CP045178.1|WP_077966864.1|4882033_4883296_+|aspartate-kinase	unknown	unknown	gnl|CDD|239779

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP045178.1|WP_077970744.1|4897211_4898105_+|helix-turn-helix-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	3.3e-13	44.8	0.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077970747.1|4894882_4895458_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.75788e-11
NZ_CP045178.1|WP_077970751.1|4892131_4893322_+|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	0
NZ_CP045178.1|WP_077970752.1|4891360_4892047_+|cysteine-hydrolase	gnl|CDD|238245	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.	4.77766e-43
NZ_CP045178.1|WP_077966819.1|4886373_4887129_+|3-isopropylmalate-dehydratase-small-subunit	gnl|CDD|179314	PRK01641, leuD, 3-isopropylmalate dehydratase small subunit.	4.31552e-95
NZ_CP045178.1|WP_077966820.1|4887125_4888022_+|LysR-family-transcriptional-regulator	gnl|CDD|176102	cd05466, PBP2_LTTR_substrate, The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily. This model and hierarchy represent the the substrate-binding domain of the LysR-type transcriptional regulators that form the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, oxidative stress responses, nodule formation of nitrogen-fixing bacteria, synthesis of virulence factors, toxin production, attachment and secretion, to name a few. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	4.61189e-47
NZ_CP045178.1|WP_077966817.1|4883299_4884337_+|oxygenase	gnl|CDD|188461	TIGR03946, viomycin_VioC, arginine beta-hydroxylase, Fe(II)/alpha-ketoglutarate-dependent. Members of this protein family are L-arginine beta-hydroxylase, members of a broader family of enzymes dependent on Fe(II), alpha-ketoglutarate, and molecular oxygen. Enzymes in the broader family but excluded by this model include clavaminate synthase, taurine dioxygenase, and prolyl-4-hydroxylase. [Cellular processes, Biosynthesis of natural products].	1.63959e-30
NZ_CP045178.1|WP_077970733.1|4899871_4901116_-|hypothetical-protein	gnl|CDD|376749	pfam02255, PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilized by a centrally located metal ion. Separation into subunits is thought to occur after phosphorylation.	0.00616873
NZ_CP045178.1|WP_077970753.1|4889208_4891206_-|FAD/NAD(P)-binding-protein	gnl|CDD|379196	pfam13454, NAD_binding_9, FAD-NAD(P)-binding.	8.39442e-39
NZ_CP045178.1|WP_077970768.1|4893434_4894067_+|aldo/keto-reductase	gnl|CDD|381304	cd19078, AKR_AKR13C1_2, AKR13C family of aldo-keto reductase (AKR). The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.	1.68689e-84
NZ_CP045178.1|WP_077970745.1|4895680_4897147_-|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.34638e-63
NZ_CP045178.1|WP_107502762.1|4888077_4888476_-|cupin-domain-containing-protein	gnl|CDD|315619	pfam12973, Cupin_7, ChrR Cupin-like domain. Members of this family are part of the cupin superfamily. This family includes the transcriptional activator ChrR.	1.04914e-13
NZ_CP045178.1|WP_077970730.1|4901870_4902437_-|GNAT-family-N-acetyltransferase	gnl|CDD|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	8.23057e-25
NZ_CP045178.1|WP_077970744.1|4897211_4898105_+|helix-turn-helix-transcriptional-regulator	gnl|CDD|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	7.5794e-13
NZ_CP045178.1|WP_077966818.1|4884919_4886326_+|3-isopropylmalate-dehydratase-large-subunit	gnl|CDD|235490	PRK05478, PRK05478, 3-isopropylmalate dehydratase large subunit.	0
NZ_CP045178.1|WP_077966864.1|4882033_4883296_+|aspartate-kinase	gnl|CDD|239779	cd04246, AAK_AK-DapG-like, AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli (Bacillus subtilis 168), Clostridia, and Actinobacteria bacterial species, as well as, the catalytic AK domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, the lysine plus threonine-sensitive aspartokinase of Corynebacterium glutamicum, and related isoenzymes. In Bacillus subtilis, the regulation of the diaminopimelate-lysine biosynthetic pathway involves dual control by diaminopimelate and lysine, effected through separate diaminopimelate- and lysine-sensitive aspartokinase isoenzymes. The role of the AKI isoenzyme is most likely to provide a constant level of aspartyl-beta-phosphate for the biosynthesis of diaminopimelate for peptidoglycan synthesis and dipicolinate during sporulation. The B. subtilis 168 AKII is induced by methionine, and repressed and inhibited by lysine. In Corynebacterium glutamicum and other various Gram-positive bacteria, the DAP-lysine pathway is feedback regulated by the concerted action of lysine and threonine. Also included in this CD are the aspartokinases of the extreme thermophile, Thermus thermophilus HB27, the Gram-negative obligate methylotroph, Methylophilus methylotrophus AS1, and those single aspartokinase isoenzyme types found in Pseudomonas, C. glutamicum, and Amycolatopsis lactamdurans. The B. subtilis AKI is tetrameric consisting of two alpha and two beta subunits; the alpha (43 kD) and beta (17 kD) subunit formed by two in-phase overlapping genes. The alpha subunit contains the AK catalytic domain and two ACT domains. The beta subunit contains two ACT domains. The B. subtilis 168 AKII aspartokinase is also described as tetrameric consisting of two alpha and two beta subunits. Some archeal aspartokinases in this group lack recognizable ACT domains.	1.4436e-62

Protein sequences

>NZ_CP045178.1|WP_077970768.1|4893434_4894067_+|aldo/keto-reductase
MGMTVAHGPPADEARSIATIRRAYELGVTLFDTAELYGLGVGSNERLLGRAVQGFREDVLLATKFGYDLQDPATLGVALDSRPAHIREVTESSLRHLGTDHIDVLHQHRVDPNVPIEDVAGAVAELIAEGKVRYFGLSEAGPDSFVPYSPLGRGFLAGAAKPAADYPADDMRGGFDRWQPGNYEKNLRSSSMPGRAGRSPRGPGCSPRCT
>NZ_CP045178.1|WP_077970751.1|4892131_4893322_+|pyridoxal-phosphate-dependent-aminotransferase
MSSSNRAAGARFGAVEASATFAVFDRVARLRAEGVDVLDLGGGEPDFGTPTHVVDEAVDALRGGFTHYTPSRGVPALLDAVSDKLAKDNGIVVDPATDIVITPSAKHALFAALTTLLDPGDEVLIPTPSWVSYPAMARLIGARPVQLALDPEDGFRITRELLEQHVTSRTKALLVNSPNNPTGRIMTRDEARAIGRFADEHDVLMIADEIYEKIVYDGHDHLSLASLPCCADRTLTVNGFSKGYAMTGWRLGWAAGPTDLMEQLLKVQQHTVGCAGSFVQRGGVAALMGPQEPVERMAARYAARRDVLVRGLNALPGVVCAPPEGAFYAFADIRGTAGFTDSAAFADRLLQETGVALMPGSAFGPGGEGFVRLSFATSSRVLEESLERMGRALTGW
>NZ_CP045178.1|WP_077970752.1|4891360_4892047_+|cysteine-hydrolase
MTTPGDGTPGDNTPRGGTPGSGTSRGTGTGTADERRPALLVLDLINEIVHEDGKYAADGYYAQARERGVVERAAQAIARARAADIPVIYVVVGFSPDYREWTPDSPVFAKAKDDGRLVLGTWATRVHDALKPEPGEPVIVKHRVSPFHGTDLAARLRDRRIDTLLLTGVSTELVVLATAQGAHDRDYAVHVLEDATLAGDEEIHTAALKILARVADVTTVAAALPATA
>NZ_CP045178.1|WP_077970753.1|4889208_4891206_-|FAD/NAD(P)-binding-protein
MDRRRRVQEMKVAIVGSGPRGLSILERMAARLAEHPVAEETVIYLIDSHRIGSGRVWRSDQPEWFLMNTVADEVSAFSGPPDGGPTRPGAGPSLAQWWSGLDPDYPGPNSYAPRALHGRYMHFILRTIEGNLPEGVRLVRVRGTVDDLARTDDGYRLVLREGAWLTADRVVLATGHTTPELTGTQRVLAAYAGRTPGLRHIAGDSAADMPLDDIPAGSSVGVLGLGLSFYDVMAALTEGRGGRYEEDGEGGLVYRPSGTEPVIVAGSRSSMPLPARGRNQKHHDHRYDHLLFTTERILAHSRHGEISFAEDAVPWLLAEVELVYYATTLISRHGPEHGPERAAAFRADVVAAARDGVPDVVALAAGYGLGDVPRIDLDAQARPFAGQHFEGPDDFEAALRSALARDLAHAEAGNVDDPLKAGLDVIRDSRAVIRSLVDFAGLTPASHREEFLGWYVPRSSFLAAGPPRTRLRQVAALLARGVLRVVGPDTRFRPDPESGRFAVHSPYVAESKVLVDTVVDARVPIPDVRLDPHPLTRRLRERGIWTSFVNHGADGDRFDTGGVAVTEAPFHPVGREGLPDEGLYVLGIPTEHTRWFMQGGSSRPGFWTDFVQNADAIAADVAAAARRPVVEVPDPEVPDVEAPAVVRVPAAGPRDLRVPTAPVAV
>NZ_CP045178.1|WP_107502762.1|4888077_4888476_-|cupin-domain-containing-protein
MSQPAAPAVAQPREVTVVRDIFDPVGLDALPWEHWAEPGRAGVELHRLYLTDDDAAGAAMITRMAPGAHGDLHEHLGHELILVLEGELRNDNGDRYRPGDLVIEEPGSVHRVSTVTGCTVLGVRHAATRPVG
>NZ_CP045178.1|WP_077966820.1|4887125_4888022_+|LysR-family-transcriptional-regulator
MKLSQCVAFVAIADTGSFTNAARALGISQSAVSHAIAGLETELGVTLMVRDRSGIELTDAGRRALEPARGMALQEERVRRAVRAEPAEPEGTLRIGTSQSFAARLLPALMTELHTRYPMLEIVLHEGTDAQISQWLRGHSIDIGIVNLPKRGLATAPLLQDEMLAIVPYGHDGAGRPEVHIEELAREPFLMPVGGVEAMVRSAFRTEGLEPTVSHQVRDVNALLAMVAAGLGATVLPRLALPFALPEVRVLPLAPAIVRHLGIGTRLGSQESPVVAAFVDVARSLAARSDWRRIPLAV
>NZ_CP045178.1|WP_077966819.1|4886373_4887129_+|3-isopropylmalate-dehydratase-small-subunit
MEQFVRHTGTVVPLRRTDVDTDQIIPARFCASTSRSGHAAALFADWRTEPGFVLDRPERAGASILVAGTDFGTGSSREYAVWALQDHGFRVVVAPRFGDIFRANSLMNGLLSVTLAPASVEYLWELTEADPGARVTVDLERGEVRCAGLVERFTLDEDVRRRLLGGLDVIADTLRFEADIGRYEGTRRAALPVTRGRAPGTYEGPPVTYGGPPGTYGGPPGTYGGPPVARGQALFAYDETPVFRGDTTVTS
>NZ_CP045178.1|WP_077966818.1|4884919_4886326_+|3-isopropylmalate-dehydratase-large-subunit
MGRTLAQKTWDAHVVRRGGEGVGDDLLYIDLQLLHEVNTPQAFDRLRAAGRTVRRPDLTVGTEDHNTPTLALDRVIKDREGRRQAELMRSNCAEFGIPLHRFGDPGQGIVHVIAPELGLVRPGMTIVCCDSHTTTLGAFGALALGIGASQVEHVLATQTLPMRRPRSMAVDVTGTLPEGVGAKDLVLALIARIGTAGGQGHIIEYRGEGVTALSMEARMTLCNMTVEAGSRAGTVAPDETTFAYLSRCPGMPEGAEWEREVAYWRSLATDADAPWDRRVTLDAAALSPYVSWGTNPAQSVPLDGRVPAPAEFATPETRAAAERALEYMDLKPGTALREVTVDTVFLGSCTNSRIEDLRAAAGVLRGRKVADGLHMMIVPGSARVRRQAVEEGLDRVFAEAGADFRAGAGCSMCAALNEDRLLPGQRAASTTNRNFEGRQGKGSRTHIVSPSVAAATAVTGRLSSPADL
>NZ_CP045178.1|WP_077966817.1|4883299_4884337_+|oxygenase
MTATTDLGATAAAVTVPTFREIALPDEVRDSLGEQLGRLADPNVDIDRSMARLHQIFATIPTELLQQLLDFGRHNDTPGVALVSNLPVDAELPPTPSDGGPSTEKTSFVAEGVLLGLSGLLGEPMGVLTEKAGQLVHDVIPVAGGSKTQTNQGSEVFLNFHSDIMHDVIGRYDIANPDFLVLSCLRQDHDGLAGTYYADARDISAALPAETLETLRSPLFRLNAPGSYVRNVAGGQDVLSEPVPMISGHDTFPEIAISANGVHALTSGAREALETLQATCKRVSHEVLLAPGQAMLINNRKGVHARSTFTARYDGADRWLQRTYVRRSLWNVRYRVTDENRRVHY
>NZ_CP045178.1|WP_077966864.1|4882033_4883296_+|aspartate-kinase
MALAGRRQPHHRRRPQRDPDRGGAHRAGHPVRASPAATDSSDAGLRAPAVLKFGGSSFRTLASYAQLAEDLSRRVEEENTHLVVVVSGQPGETEQFRERLSQVNPHPEDETVAGLLTLADTVGAQLLATALHRRGRTATVLAGHQLGLTTDSSFMWARLEHTDPEPLRTAVRDNEVVVIPGGQAADKEGRPTWLGKNSSDLSAVAVAAAVGAARCEIHSDVDGIYSCDPHLVSGSKLLSQVSYNTAALMSLYGAKVLHRRAVRLAQRHKIEIVCRYNRAPFPTGSVIGTAGSTVAAVVLNQRSAALRYETDDLADQAYKVFHGANIDVVRLTSGPLVAVTGGFVDLPEFQRRHGLTPGEYAGVPLTAVRGSQVVTQLAADEEDALHVAQRLHDHVNRPGTDVGPQAPLPELMELLEMQGA
>NZ_CP045178.1|WP_077970747.1|4894882_4895458_-|TetR/AcrR-family-transcriptional-regulator
MATAERLIESTRALLWERGYAGTSPKAIQQRAGVGVGSMYHHFDGKSGLALAAMERSARELRESAEDHFTGPGTAAERIAGYLLRERDVLSGCPVGRLSMDSEVVAEDRLRAPLDSLFGWLRIRLSELVAEGQRAGELDAGLDPRAVGATIVAVVQGGYVVSRSAESPEPFDAAVRGALQLLGHRRPPPLR
>NZ_CP045178.1|WP_077970745.1|4895680_4897147_-|DHA2-family-efflux-MFS-transporter-permease-subunit
MTTTGVPSTTATEPPTTTPGAVQPVLALPPLIALSLGYFLVMLDVTVVNVAIPDIRVSLGAGSSALQWIVDGYSTVFAGLLLLGGGFADRLGHRRMFLVGLGVFTAASLACALAGSPGTLIAGRLAQGAGAALLVPASLALLQATYPDRALRARAIAIWGAVASVAFGAGPAVGGLLVSGSDWRSVFWLNLPVGALAVHLTLRHIPASARKPAARRMDPLGQVLGIIGLVGLAGGLNEAGTHGWASPLVLSAFAVGVVALVAFALVERTLEYRGASGRTDRAPLLPPSVFRSRAFTSTAAIGLLISLGYYGMLFLTTLYFQQERGFSVLTTGLALLPSVCMGLVAAPLFGRLAARTGPYVPMAAGLVLGTAGFLGWLLAGPHTAYPVLLFALIATGLGQTMTALAATAAIIEAAPASGAGIASAVFNVSRQVGSTVGVALFGTFAAASADFTSGLRLSAGLAAAAFATGALLALSVRRRAAAPTPDSA
>NZ_CP045178.1|WP_077970744.1|4897211_4898105_+|helix-turn-helix-transcriptional-regulator
MPNTDRTTAGPPRTTNDPTTAPARAVSGPAAPENAGVRAGKGPGERAAEPLKHQTDIARVAALIADPSRARILKCLADGRALPAGALAGEAGIGAATASAHLAKLVEGELVTVERSGRHRYYRLHGPDVSAALEALALIAPPQRITSLKQSNRTNALHRSRTCYDHLAGRLGVALMRTLLERGVLTGHDGVHRPREAVRDRPSAYGRDIRYELTETGRATLTELGVDPDRLPPRRPAIRYCVDWSEHQHHLAGGLGAALTARLFALDWVRWGASPRVVHLTDRGAEGLERSLGLVVG
>NZ_CP045178.1|WP_143621410.1|4898179_4898761_-|hypothetical-protein
MNWPHVDYDADLWMRVPDSWDGTPWKGPKDWARHMSDACWDDSDLDPSRKDRKALAETLRQCAERFPQSYPGFDLYLHLPDPRFMPLPVYVASVEADGDREETLRALVTTDDADLVEDPIVEEFTTDLLGTGMRSLRYTRTGEERTIVAGVRYAWRAEKVGCDVVVIAAAPDPRRVLGAMDDLDAFAARIRVG
>NZ_CP045178.1|WP_077970736.1|4898757_4899384_-|hypothetical-protein
MTDRTGIAPRGYELVLPPEWARIPMRSGTREAVRAIVDDAFSRLPADTPPDRVGPYRRELERRLNDAVEEARRAEALDLYLPLERMHGIAVAASIVVSEMNFPDEVAVDPSAVAHRLLEAPGRAGRTSAVEVDEVPGVRTERTAKAGQDGSELASRRVDYVVPVPDDPGRWVSVVFSTVGAGQPDDELADLFVELFDAMMSTFRWSRS
>NZ_CP045178.1|WP_152330786.1|4899380_4899875_-|hypothetical-protein
MRRGRDEPGGRYFADLDRRGREKEEAREAAERAYSKDVGVVRVISLVPPLLYCAAMIVGAASEGAAMFVLRYVLGPAGVVATAFMVWLILRYERSPERDYGVPMVVHGGALLGCLTGFATDAVAFVLIPLAAPLVQWGLPKYRTTRERLRERRRASDAAERRKP
>NZ_CP045178.1|WP_077970733.1|4899871_4901116_-|hypothetical-protein
MARPTDWKPLADSDPVPGDPRQIRDEVEHMKKVAKKLRDQADRLGKIAKKEGLKGKYSETLTDGAGELAKKLDQAAGRYETVKTHLSGWADDLQGAQTSAKAALDLAKDDEEQAKKDLKKAKESYDNAADHHAGLIEKAIDDDALTDSWWDNVKDWVDKNAGWLKVVIEVASYVATALAIAAIFVSGIGIGVVLAAGIAVLVARVGMAAAGQGSWADVALDVFALATMGLGRGAVSGLKAGQAATRLAAAQGAKKAATSTAKNGMREVYGQAGRTLAAKGAKRGARRSARETIENANKLADQAGDGAEMMARKAPLPKVSKMDVIKAGGDKDAAVAYKDIVRTRAAYAEHAGVHAASEGSEAMLRLNQQVFLSGQGIDLGGKALGSSDTVTDKPYFEPFQDYKNEYTAEVGSTW
>NZ_CP045178.1|WP_077970731.1|4901118_4901427_-|hypothetical-protein
MSDLTVDIELLTASEKELISIKGEFDGIGDWKKEVQSALGAGRMVGAMGTFVDNWDRHRKELVGEIEQVGGFVSSCRKGFEKVDRDLAESARKARRDKKKEK
>NZ_CP045178.1|WP_077970730.1|4901870_4902437_-|GNAT-family-N-acetyltransferase
MQPIDFTAGPVTLREFAAGDVAAVFAVYGDAAATRHLSFEPRTEAETRAIVARAMGSAPADPRTEYGLAVTRTDGGGLIGFGRLALDPHQPRGATMGFALRPDTWGHGYGTATVRALLGLAFGPLSLHRVWGARSPLNEASAATMARAGMVEEGRIREHIQKGGQWRDSVVHAILDREWARQRDLTSL
>NZ_CP045178.1|WP_077970728.1|4902462_4903776_-|hypothetical-protein
MHTLFRQLCDRQELKHPKAFQARFRVVAQELAAEESDPDLLTCCPADTTIEGWYYGKRTPQRDARRVIVRMFGHSIEQLWKPAAHGIHRDSPGALTEMRGIAEMAARRAREFALGAERGQLGDETLGFLQDEVARIAAVYQRVPLPTLFPDLSAAQENAFRLIEGGRVRPGQLRQLQVCASLLSWFMAKASHDMGDTHSAMMQARTAGVCAGQAEHPGLLAVVDGVKSLITYWAGRPEDAVFFARKGAAEHPALRGSVSAWLPALEARAAALLGDAEAVHEANRRAEDARSGITPDDLDNLGGVLAFPEAKHGYYTAESRVLLGLSDKETTERADAATAAYQDRTTAHWAFDDEAGSRCNLAIVRLHADSPDSLEGAADAIRPVLDLPPAQRNNGIVVSAGRVAAALAESRAGRSPAGLQLRDEIGQFDTSRLALPG

Crispr_ID: NZ_CP045178_16

• CRISPR_ID: NZ_CP045178_16
• CRISPR_location: 4994405-4994565
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP045178_16

Consensus_repeat	Method
GGTGCGGCTGGGCGCGGTGTGCG	CRISPRCasFinder

spacers of NZ_CP045178_16

>16.1|4994428|43|NZ_CP045178|CRISPRCasFinder
TACGACTACGGGGCGCGGGGTGCGCACGACGGCGCAGTCGGTG
>16.2|4994494|49|NZ_CP045178|CRISPRCasFinder
CTCGGCGGGTGGTGCGGGGTGCGATGTGCGCCTGCTCTCGCGCTCGACC

CRISPR arrays and Neighbor proteins around NZ_CP045178_16

CRISPR arrays

The CRISPR arrays of NZ_CP045178_16

>merge|NZ_CP045178|16|4994405-4994565|CRISPRCasFinder
ACGACAGCGGGGCGCGGGGTGCGTACGACTACGGGGCGCGGGGTGCGCACGACGGCGCAGTCGGTGGGTGCGGCTGGGCGCGGTGTGCGCTCGGCGGGTGGTGCGGGGTGCGATGTGCGCCTGCTCTCGCGCTCGACCGGTGCGGCGGGGCGCGGTGTGCG

>NZ_CP045178|16|12|4994405-4994565|CRISPRCasFinder
ACGACAGCGGGGCGCGGGGTGCG	TACGACTACGGGGCGCGGGGTGCGCACGACGGCGCAGTCGGTG
GGTGCGGCTGGGCGCGGTGTGCG	CTCGGCGGGTGGTGCGGGGTGCGATGTGCGCCTGCTCTCGCGCTCGACC
GGTGCGGCGGGGCGCGGTGTGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077970557.1|4990512_4991373_-|dihydropteroate-synthase	unknown	unknown	gnl|CDD|238380
NZ_CP045178.1|WP_077970555.1|5001980_5003495_-|PH-domain-containing-protein	unknown	unknown	gnl|CDD|225962
NZ_CP045178.1|WP_077970550.1|4996001_4997183_-|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213262
NZ_CP045178.1|WP_077970559.1|4990021_4990516_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|379209
NZ_CP045178.1|WP_077970536.1|5005178_5006510_-|hypothetical-protein	unknown	unknown	gnl|CDD|224481
NZ_CP045178.1|WP_077970563.1|4988645_4989254_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl|CDD|223872
NZ_CP045178.1|WP_077970571.1|4984205_4984769_+|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl|CDD|223707
NZ_CP045178.1|WP_077970547.1|4999134_5000118_+|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270324
NZ_CP045178.1|WP_077970569.1|4984973_4987022_+|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl|CDD|273520
NZ_CP045178.1|WP_077970567.1|4987190_4987796_+|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl|CDD|236472
NZ_CP045178.1|WP_077970572.1|4983017_4984148_+|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|274129
NZ_CP045178.1|WP_077970548.1|4998186_4998978_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224095
NZ_CP045178.1|WP_077970561.1|4989250_4989610_-|dihydroneopterin-aldolase	unknown	unknown	gnl|CDD|376737
NZ_CP045178.1|WP_077970565.1|4987966_4988458_-|DUF3180-domain-containing-protein	unknown	unknown	gnl|CDD|378650
NZ_CP045178.1|WP_077970573.1|4981679_4982807_+|zinc-dependent-metalloprotease	unknown	unknown	gnl|CDD|274833
NZ_CP045178.1|WP_077970549.1|4997461_4998190_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224095
NZ_CP045178.1|WP_077970545.1|5004071_5005214_+|NADH-quinone-oxidoreductase-subunit-D	unknown	unknown	gnl|CDD|223722
NZ_CP045178.1|WP_143621395.1|5001256_5001754_+|hypothetical-protein	unknown	unknown	gnl|CDD|237171
NZ_CP045178.1|WP_077970551.1|4994589_4995735_+|esterase	unknown	unknown	gnl|CDD|225256
NZ_CP045178.1|WP_077970553.1|5003506_5004040_-|PH-domain-containing-protein	unknown	unknown	gnl|CDD|225937

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077970557.1|4990512_4991373_-|dihydropteroate-synthase	gnl|CDD|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	7.73061e-115
NZ_CP045178.1|WP_077970555.1|5001980_5003495_-|PH-domain-containing-protein	gnl|CDD|225962	COG3428, COG3428, Predicted membrane protein [Function unknown].	9.46818e-41
NZ_CP045178.1|WP_077970550.1|4996001_4997183_-|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein	gnl|CDD|213262	cd03295, ABC_OpuCA_Osmoprotection, ATP-binding cassette domain of the osmoprotectant transporter. OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.75242e-148
NZ_CP045178.1|WP_077970559.1|4990021_4990516_-|nuclear-transport-factor-2-family-protein	gnl|CDD|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	3.97855e-28
NZ_CP045178.1|WP_077970536.1|5005178_5006510_-|hypothetical-protein	gnl|CDD|224481	COG1565, COG1565, Uncharacterized conserved protein [Function unknown].	9.54863e-17
NZ_CP045178.1|WP_077970563.1|4988645_4989254_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl|CDD|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	1.52353e-65
NZ_CP045178.1|WP_077970571.1|4984205_4984769_+|hypoxanthine-phosphoribosyltransferase	gnl|CDD|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	9.64352e-90
NZ_CP045178.1|WP_077970547.1|4999134_5000118_+|ABC-transporter-substrate-binding-protein	gnl|CDD|270324	cd13606, PBP2_ProX_like, Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold. This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.36691e-84
NZ_CP045178.1|WP_077970569.1|4984973_4987022_+|ATP-dependent-zinc-metalloprotease-FtsH	gnl|CDD|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
NZ_CP045178.1|WP_077970567.1|4987190_4987796_+|GTP-cyclohydrolase-I-FolE	gnl|CDD|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	3.62144e-115
NZ_CP045178.1|WP_077970572.1|4983017_4984148_+|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|274129	TIGR02432, tRNAIle-lysidine_synthase, tRNA(Ile)-lysidine synthetase, N-terminal domain. The only examples in which the wobble position of a tRNA must discriminate between G and A of mRNA are AUA (Ile) vs. AUG (Met) and UGA (stop) vs. UGG (Trp). In all bacteria, the wobble position of the tRNA(Ile) recognizing AUA is lysidine, a lysine derivative of cytidine. This family describes a protein domain found, apparently, in all bacteria in a single copy. Eukaryotic sequences appear to be organellar. The domain archictecture of this protein family is variable; some, including characterized proteins of E. coli and B. subtilis known to be tRNA(Ile)-lysidine synthetase, include a conserved 50-residue domain that many other members lack. This protein belongs to the ATP-binding PP-loop family ( pfam01171). It appears in the literature and protein databases as TilS, YacA, and putative cell cycle protein MesJ (a misnomer). [Protein synthesis, tRNA and rRNA base modification].	5.66697e-60
NZ_CP045178.1|WP_077970548.1|4998186_4998978_+|ABC-transporter-permease	gnl|CDD|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	5.54888e-57
NZ_CP045178.1|WP_077970561.1|4989250_4989610_-|dihydroneopterin-aldolase	gnl|CDD|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	6.06169e-44
NZ_CP045178.1|WP_077970565.1|4987966_4988458_-|DUF3180-domain-containing-protein	gnl|CDD|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	6.46355e-29
NZ_CP045178.1|WP_077970573.1|4981679_4982807_+|zinc-dependent-metalloprotease	gnl|CDD|274833	TIGR03883, DUF2342_F420, uncharacterized protein, coenzyme F420 biosynthesis associated. A phylogenetic tree of the DUF2342 family (TIGR03624) consists of two major branches. One of these branches, modeled here, is observed almost entirely to be found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family includes a Chloroflexus Aurantiacus protein whose crystal structure has been determined (PDB:3CMN_A). This has been annotated as a putative hydrolase, but the support for that assertion is untraceable. There is no cofactor present in the structure.	2.70969e-166
NZ_CP045178.1|WP_077970549.1|4997461_4998190_+|ABC-transporter-permease	gnl|CDD|224095	COG1174, OpuBB, ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism].	4.43521e-58
NZ_CP045178.1|WP_077970545.1|5004071_5005214_+|NADH-quinone-oxidoreductase-subunit-D	gnl|CDD|223722	COG0649, NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion].	7.83479e-144
NZ_CP045178.1|WP_143621395.1|5001256_5001754_+|hypothetical-protein	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.000302917
NZ_CP045178.1|WP_077970551.1|4994589_4995735_+|esterase	gnl|CDD|225256	COG2382, Fes, Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism].	2.79204e-05
NZ_CP045178.1|WP_077970553.1|5003506_5004040_-|PH-domain-containing-protein	gnl|CDD|225937	COG3402, COG3402, Uncharacterized conserved protein [Function unknown].	3.27142e-28

Protein sequences

>NZ_CP045178.1|WP_077970557.1|4990512_4991373_-|dihydropteroate-synthase
MSTLHGRGRVEGLPEWDRCAVMGVVNVTPDSFSDGGRWFDTAKAVKHGIELVAHGADLVDVGGESTRPGAPRVDEDEELRRVIPVVRGLAAEGVTVSVDTMRARVAEQSLAAGAVLVNDVSGGLADPAMVPVVAAADVPFVVMHWRGFSERMNSLAVYADVVSEVVSELRARVEAVVEGGIAPERVIVDPGLGFAKQADHDLALVARLDRLHELGRPLLVAASRKRFLGRVLAGPGSEPPPARERDAATAAISALTAQQGAWAVRVHEVRATADAVRVARAVEGAV
>NZ_CP045178.1|WP_077970559.1|4990021_4990516_-|nuclear-transport-factor-2-family-protein
MTTPGTETEEVELANTAFYEAMEHGDFDVLSGLWLDEEGVSCVHPGWPVLTGRGEVLRSYALIMANTEYIQFFLTDVTVEVSAGTAVLTCTENILSGGPAPEEGDELGPLVGQLVVATNVFRRTSDGWKLWSHHASPVLTETEADDEQAEDEDAGPGDSGGSPA
>NZ_CP045178.1|WP_077970561.1|4989250_4989610_-|dihydroneopterin-aldolase
MDRVALRGLKARGHHGVFPREREEGQTFIIDLTLGLDTRAAAADDDLTKTVHYGVVAEEVVGVVTGEPVDLIETLAHRIAQTCLKHDGVLEVEVCVHKPDAPITVPFDDVTVTITRSRV
>NZ_CP045178.1|WP_077970563.1|4988645_4989254_-|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MTAFTQGQSDPTVQPVPASVVERVDAADSTLSNPKRAVVALGSNLGNRLETLQGAIDALEDTPGLRVKAVSRVYETEPWGVEPGSQPSYFNAVVVIRTTLPPSSLLERAHAVEEAFHRVRTEHWGPRTIDVDIVSYADVVSDDPELTLPHPRAHERAFVLAPWHDVDPEALIPGRGGITELLSAVGSEGVVPRDDLELVLPE
>NZ_CP045178.1|WP_077970565.1|4987966_4988458_-|DUF3180-domain-containing-protein
MKQLRIRTMAGLFVVAGVLSWAGARLWDSLGTLPGVPVAAPIVLAVVAMLLLVTALSIRSRLRAQRERRPGAQGVDPLVAARSVVLGQASALVVSLVAGLYGGTGVFLLGSLDIPARRDQAIYAGLSVIAGIAVVAAAVFLERVCKLPEDDDEGGGGSAAPTT
>NZ_CP045178.1|WP_077970567.1|4987190_4987796_+|GTP-cyclohydrolase-I-FolE
MTDAVTLDGEGSIGEFDEKRAADAVRELLLAVGEDPDREGLRETPARVARAYKEIFAGLWQKPEDVLTTTFDLGHDEMVLVKDIEVQSSCEHHLVPFVGVAHVGYIPSADGKITGLSKLARLVDVYARRPQVQERLTTQIAESLMEILEPRGVIVVVECEHMCMSMRGVRKPGAKTITSAVRGQLRDPATRNEAMSLIMAR
>NZ_CP045178.1|WP_077970569.1|4984973_4987022_+|ATP-dependent-zinc-metalloprotease-FtsH
MDVKRYFRGPVMWIVLAVLAVVVLMQVVGSSGGYKTVDTGQVVQAINENHAKSAKLTTGDEQTIKVELKDGQKVKGSSKIQASYIGDQGAQLAKTLQDKFDNKQINDGYTVQPSKQNPFVGILLSLLPIILIVVLFLFLMNQMQGGGSRVMNFGKSKAKLLTKDTPKTTFSDVAGSDEAVEELHEIKEFLQEPAKFQAVGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKANAPAIVFVDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFDVKGGVILIAATNRPDILDPALLRPGRFDRQIAVDRPDMQGRLEILKVHQKGKPVTPDVDLAAVARRTPGFTGADLANVLNEAALLTARSDKKLVDNSMLDEAIDRVVAGPQKRTRIMSDKEKKITAYHEGGHALVAAASPNSDPVHKITILSRGRALGYTMVLPEEDKYSTTRNEMLDQLAYMLGGRAAEELVFHDPTTGAANDIEKATSTARSMVTQYGMTERLGAIKFGADNSEPFVGREMGHQRDYSEEVAALVDEEVKKLIETAHNEAWEILVENRDVLDNLVLELLEKETLGKEQIAEVFAPIVKRPARPAWTGSTRRTPSTRPPVLSPRELHLTNGANGTAPAVTSGVSTEKAPTGTESEPSPAPEDRPES
>NZ_CP045178.1|WP_077970571.1|4984205_4984769_+|hypoxanthine-phosphoribosyltransferase
MRVDAKDMGTDLESVLLTKEEIDAKLAELAAKIDAEYAGKDLLLVGVLKGAVMVMADLARALSTPVTMDWMAVSSYGAGTQSSGVVRILKDLDTDIKGKHVLIVEDIIDSGLTLSWLLTNLGSREPASLEVCTLLRKPDAAKVAIDVKWTGFDIPNEFVVGYGLDYSEKYRNLPFVGTLAPHVYGGA
>NZ_CP045178.1|WP_077970572.1|4983017_4984148_+|tRNA-lysidine(34)-synthetase-TilS
MGPHPAVAAIRLAVRRVLHDVLTQYQHGEHPARRAAPPHGGPPAQHPERLATPPEWAAGILRASRPFRPPLPDAPLVLVACSGGADSMALASALAFEAPRLGIRAGGITVDHGLQIGSDIRAAEVAARLTALCLDPVDSVAVDVGRDGGPEAAARDARYAALDAAADRHSAAAVLLGHTRDDQAETVLLGLARGSGTRSLSGMADVSGTEGRYRRPFLRVDRQTARRACMVQSLPVWDDPHNTDPAYTRSRLRHEGLPALEKALGKGVVEALARTAQLSRDDADALDAWAARAEPSVRDDSGHLDCAGLYALPPAVRRRILRSALLDAGAPAGALFARHIEEVDRLITGWRGQRAINLPGKVEARRQGGRLVIRQG
>NZ_CP045178.1|WP_077970573.1|4981679_4982807_+|zinc-dependent-metalloprotease
MTSIGGAQMVDWNLAVATATRLARPGPEVSRDEARAIVAELRRHAKSAEEHVRSFTGMATDEVTDTPVLVVDRPGWTRANVAGFRELLKPLLDKMRDRRGSGPGGAVLGAVGGKVTGVELGMLLSFMSSRVLGQYETFAPATRALPAASGGGRLLLVAPNIVQVERELEVDPHDFRLWVCLHEETHRTQFTGVPWLRDHLESEIQEFLAQTEVDPMTFLERLREAAQSLATGRGEDSGEDAGEGRSIVELVQTPAQREILGRLTAVMSLLEGHADFVMDGVGPAVVPSVAEIREKFQQRRAHGASRLDLALRKLLGLDAKLRQYRDGERFVRAVVEEVGMEGFNRVWTSPNTLPTKAEIGKPMEWVARVHRKTES
>NZ_CP045178.1|WP_077970551.1|4994589_4995735_+|esterase
MGLTSHKVLAGVVLVAVLLFIATVWWWPRLARSSWRTVLGRVGLLSATQLMVFAAVGLAANQAFGFYASWADLMGREQTPGTVVEHRSAATAADTRGGESADGGRLRVNGVEPLPGGARPAAGGQLQRVDIAGGVTGTVTPAFVYLPPEYFQPRYRDRSFPAVTVLTGYPGTAEALIKGLHYPQTARKQVAAGTAQPMVLVMLRPTVAPPRDTECVDIPGGPQVETFFARDLPKVISGHYRIGAKAESWGVVGDSTGGYCALKLALHHPGAYAAGAGLSAYYRAAEDPTTGDLFHGDESLRRRADLMWGLRHLPMPRTSLLVTSSKEGEDNYRDTERFVAAVRPPARISSIVLDSGGHNFTTWRREIPATLQWLSGRLSVG
>NZ_CP045178.1|WP_077970550.1|4996001_4997183_-|betaine/proline/choline-family-ABC-transporter-ATP-binding-protein
MIRFEHVTKRYDSGGEGSAAVDDLSFEVAEGELVTLVGPSGCGKTTTMKMVNRLIEPTSGRIFLDGEDIATIDPVRLRRRIGYVIQQVGLFPHKTVLENTATVPHLLGWKRGKAKERAAELLDLVGLDPSAFGDRYPEQLSGGQRQRVGVARALAADPPVLLMDEPFGAVDPVVREHLQSEFLRLQSAVRKTVLFVTHDIEEAVRLGDRIAVYGQGRIEQFDPPTTVLGSPATPYVADFVGADRGLKRLSVTPIEPGDLEQPPVVHVDDPLSTAADRLRAEDARWAVVLDGDNNLHGWIGAEHVGGEGRAGTVGEHARRMEAWLPVGATLKQAFSTMLQHDAGWIAVIDERSEGRFLGVLTPAGLHEALRRSTAADAQAIPRTDVALETVSGR
>NZ_CP045178.1|WP_077970549.1|4997461_4998190_+|ABC-transporter-permease
MSGQSCLETNAWICGEYFRTRSQELTDATVQHVLITVVSVAIGLAIALPLALLARRRKAFAGPILGVTTVLYTLPSLAMFSLLLPVFGLSAALVVTGLVLYSLTILVRNILAGLEAVPEEAREAARGMGYGPWRLLLEVELPLALPALLAGVRIATVSTVALTTVGAIVDYGGLGSLILDGLDTTFKAQVLAASVLCVVLAVAADLLLLLLQRLLTPWTRAHRVRTPRAPAGPAQAKAAEPA
>NZ_CP045178.1|WP_077970548.1|4998186_4998978_+|ABC-transporter-permease
MNDAITGAWTWLTTSAHWQGEKGVLHRLAEHLYFTGVCLAVACVVALPIALLLGHLGRGGALAINISNVGRAVPTLAVLVLLTITPLGEYGDLPTLIALVLFAIPPLLTNAYIGMREVDTSVVEAARGMGMSGKQVFSRVELPLAYPLIMTGIRTSAVQVVATATLAAMAGEGGLGRIITAGFNLQNTPQVVAGAVIVAVLALLIEVVLVVAGKVFDPMRRRASRTAHADSAPTDGPDEGAGTPTGAADVVTAGGRGSAALGS
>NZ_CP045178.1|WP_077970547.1|4999134_5000118_+|ABC-transporter-substrate-binding-protein
MSMNSRRVRTAGAVLGALSLAAGLTACGGDSLEDSGKGSGKSSGDSGGKKGSLVIGAARFTEAKVMAELYARILGDAGYDATVKTVQNREVYEPELRKGKIDIVPEYAATVAEYLNLAKNGPDAKPVASSDADATFAALQKLAEPAGLKALPHGEAVDQNAFAVTEAYAKQHDLKTLSDLGEAKLKVKVAAGDECETRPFCGPGLKSKYGIDVTGIDPKGVGTPQAKQAVKNGSDQLVLTTTTDASLKSYGLVILDDDKKLQNADNILPLVNAKDAGGKAIADVLDKLTKTLTTQDLVELNRKVDAEREKEKDVASDYLTSKGLIKK
>NZ_CP045178.1|WP_143621395.1|5001256_5001754_+|hypothetical-protein
MAPRPAARRPAVGGFDFFGTQGGVAQGGGTQGGQGARRAAPRAIEAVQNEDLADVVGEEALAVHRAQNEAAEPAEPTASTEPTEPAEELALTAVAAGTPAEQATPQRRTEERKAATGGGADGTEAGEFESPAESSEDRSGQVIDLTEHDETEQLDVERLRAAMRA
>NZ_CP045178.1|WP_077970555.1|5001980_5003495_-|PH-domain-containing-protein
MPSGETSGTASGAGLGGGRGSAGTSGDGDAPGEGLLTKGTGPDVVAQGPDAVARARGADVVAEGPDAGPRERRLHPVTPLRRAWAPIALVAGWAVHDPGGAYQRLSDLATSTLLIAVAIVVPLASIYGILSWWVTHFAITDTELRIRTGLLFRRTAHIRLDRLQAVDVTQPLLARFAGVAKLKLDVVGTNSKDELSYLGEKEARALRAELLARAAGFSPQSAHDIGEAPVHRLLRVAPRTLALSVLLSGATGGTLLAGTVVPALLWLASHSVWSVLVTAVPIIGAAGARSVGRFVNEYDWTVGESPDGLRLDHGLLDRTHETVPPGRVQTVRVVEPLLWRRFGWVRVELHVAGSSNTLLVPVAPRDEAVAVVSRVLPGVNVPQEFSPSPRRAAWCVPLWWRGYGLAVTDAVFVARTGLLRRRTSLVPHAKVQSVRLVQGPWEGSKRLAGIRVDTGANKTVTVRLRDETEAQDLLLAQADRSRTGRRTAAPDRWMSTEPPPVGTG
>NZ_CP045178.1|WP_077970553.1|5003506_5004040_-|PH-domain-containing-protein
METGTRDEPGRGRATGDSGADRPGEQVWTGLPRQLLGLRRLLLVMWLIPLAAALGVPLGLFAGPYWALFALLPLAALAWGWPVLGRNWRSWRYTERADDLLISRGVLWRRQTIVPYGRMQLVEVTSGPLERRYGLASVQLHTAAAMTDAKIPGLLPSEAERLRDRLTELGEARSAGL
>NZ_CP045178.1|WP_077970545.1|5004071_5005214_+|NADH-quinone-oxidoreductase-subunit-D
MTETMVGIGGAAESTDMVLNIGPQHPSTHGVLRLRLVLDGERIVEAEPVVGYMHRGAEKLFEARDYRQIVMLANRHDWLSAFSNELGVVMAVERMLGMEVPERAVWTRTLLAELNRVLNHLMFLGSYPLELGGITPMFYAFREREQLQNVMEEISGGRMHYMFNRVGGLKEDLPAGWLGRVAHAVDEVRSRMDVFDELVLGNEIFRGRTRDVGILSASAVHAYGVSGPAARASGVDFDLRRDEPYLAYGELQRVLKVVTRQEGDCLARFECLLDQTHNALDLAAACLERLGELAPGPVNQRLPKVLKAPEGHTYAWTENPLGINGYYLVSKGEKTPYRLKLRSASYNNIQALTELLPGTLVADMVSILGSLFFVVGDIDK
>NZ_CP045178.1|WP_077970536.1|5005178_5006510_-|hypothetical-protein
MTSEWQGWREAAGEALYGASGFYLAPDGPGAHFRTSVHASPLFAAAVARLLRRVDAALGHPDELTFVDLGAGHGELVTGVLDALPAPVAARVLPYAVEHAPRPAGLDPRVTWTGAPPTGVTGLLFANEWLDNIPLDVVESDEEGVVRTVLVRRDGEQRLGAPVGGTDAEWLRRWWPLPPPLSLDGTAEPGLRAEPGLPAETELRAEPGLRAETGLPRDEAWEAAVGTLTRGLAVAVDYAHTREARPPHATLTGYLAGRQVPPVPDGSRDITAHVALDACAARHPASRLLSQRAALRALGVDGGRPPLTMASTDPAGYVRRLASAGEAAELTATGGLGDFGWLLTPVGVELHEGTGLPGGTGLHQDPGMPGGGSTEQRRDTEVSGDTGGDGERPGDTKGSGDRPGDTKGSGDRPRDMDGDRALSGGTGPSSAPLLVDVADDEEE

Crispr_ID: NZ_CP045178_17

• CRISPR_ID: NZ_CP045178_17
• CRISPR_location: 5571804-5571929
• CRISPR_type: TypeI-E
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: cas8e,cse2gr11,cas7,cas5,cas6e

Consensus repeat of NZ_CP045178_17

Consensus_repeat	Method
TGTGGGCCGGGGCTGGGGTCCGGGGGCCGGG	CRISPRCasFinder

spacers of NZ_CP045178_17

>17.1|5571835|64|NZ_CP045178|CRISPRCasFinder
GCCGGCTGTGGGCCGGGGCTGGGGTCCGGGGGCCGGGGGGACGCCGACCGGGGGCCGGGCCGGG

CRISPR arrays and Neighbor proteins around NZ_CP045178_17

CRISPR arrays

The CRISPR arrays of NZ_CP045178_17

>merge|NZ_CP045178|17|5571804-5571929|CRISPRCasFinder
GGTGGAAGGGGGTCGCGAACCGGGGACCGGGGCCGGCTGTGGGCCGGGGCTGGGGTCCGGGGGCCGGGGGGACGCCGACCGGGGGCCGGGCCGGGTGTGGGCCGGGGCTGGGGTCCTGGGGCCGGG

>NZ_CP045178|17|13|5571804-5571929|CRISPRCasFinder
GGTGGAAGGGGGTCGCGAACCGGGGACCGGG	GCCGGCTGTGGGCCGGGGCTGGGGTCCGGGGGCCGGGGGGACGCCGACCGGGGGCCGGGCCGGG
TGTGGGCCGGGGCTGGGGTCCTGGGGCCGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077966389.1|5558842_5560315_-|CRISPR-associated-protein	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
NZ_CP045178.1|WP_077966381.1|5575884_5576352_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966382.1|5573685_5575599_+|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl|CDD|235256
NZ_CP045178.1|WP_077966390.1|5557946_5558846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	gnl|CDD|378243
NZ_CP045178.1|WP_077966378.1|5577912_5578155_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP045178.1|WP_077966383.1|5572033_5573230_-|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380492
NZ_CP045178.1|WP_107502723.1|5563418_5567387_+|helix-turn-helix-domain-containing-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_107502722.1|5570401_5570749_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966369.1|5580142_5580454_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966391.1|5557200_5557965_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl|CDD|378050
NZ_CP045178.1|WP_077966380.1|5576487_5577699_-|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|181738
NZ_CP045178.1|WP_077966368.1|5580772_5582602_+|asparagine-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl|CDD|273676
NZ_CP045178.1|WP_077966374.1|5579056_5579482_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NZ_CP045178.1|WP_077966388.1|5560250_5560805_-|hypothetical-protein	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl|CDD|187801
NZ_CP045178.1|WP_077966386.1|5567729_5569766_+|thioredoxin-domain-containing-protein	unknown	unknown	gnl|CDD|224250
NZ_CP045178.1|WP_077966371.1|5579497_5580061_-|DUF664-domain-containing-protein	unknown	unknown	gnl|CDD|368218
NZ_CP045178.1|WP_077966376.1|5578151_5578940_-|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl|CDD|238045
NZ_CP045178.1|WP_077966385.1|5569836_5570481_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
NZ_CP045178.1|WP_152330866.1|5560797_5562366_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl|CDD|378189
NZ_CP045178.1|WP_077966384.1|5571073_5571787_-|hemolysin-III-family-protein	unknown	unknown	gnl|CDD|367292

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NZ_CP045178.1|WP_077966389.1|5558842_5560315_-|CRISPR-associated-protein	cas7	pfam09344_cas7_CAS-I-E	8e-57	188.1	0.2
NZ_CP045178.1|WP_077966388.1|5560250_5560805_-|hypothetical-protein	cse2gr11	cd09670_cse2gr11_CAS-I-E	1.5e-13	46.1	0.5
NZ_CP045178.1|WP_152330866.1|5560797_5562366_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	3.5e-47	156.1	2.0
NZ_CP045178.1|WP_077966391.1|5557200_5557965_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	9.6e-30	99.0	0.0
NZ_CP045178.1|WP_077966390.1|5557946_5558846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09645_cas5_CAS-I-E	1.2e-44	146.9	0.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077966389.1|5558842_5560315_-|CRISPR-associated-protein	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	7.69586e-55
NZ_CP045178.1|WP_077966371.1|5579497_5580061_-|DUF664-domain-containing-protein	gnl|CDD|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	1.43686e-34
NZ_CP045178.1|WP_077966382.1|5573685_5575599_+|phosphoenolpyruvate-carboxykinase-(GTP)	gnl|CDD|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP045178.1|WP_077966390.1|5557946_5558846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|378243	pfam09704, Cas_Cas5d, CRISPR-associated protein (Cas_Cas5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum.	8.08979e-28
NZ_CP045178.1|WP_077966378.1|5577912_5578155_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	2.19781e-18
NZ_CP045178.1|WP_077966383.1|5572033_5573230_-|amino-acid-ABC-transporter-substrate-binding-protein	gnl|CDD|380492	cd06268, PBP1_ABC_transporter_LIVBP-like, periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.	7.69335e-37
NZ_CP045178.1|WP_077966391.1|5557200_5557965_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl|CDD|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.61976e-41
NZ_CP045178.1|WP_077966380.1|5576487_5577699_-|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|181738	PRK09265, PRK09265, aminotransferase AlaT; Validated.	0
NZ_CP045178.1|WP_077966374.1|5579056_5579482_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	7.62901e-19
NZ_CP045178.1|WP_077966388.1|5560250_5560805_-|hypothetical-protein	gnl|CDD|187801	cd09670, Cse2_I-E, CRISPR/Cas system-associated protein Cse2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;.	2.65957e-08
NZ_CP045178.1|WP_077966386.1|5567729_5569766_+|thioredoxin-domain-containing-protein	gnl|CDD|224250	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP045178.1|WP_077966368.1|5580772_5582602_+|asparagine-synthase-(glutamine-hydrolyzing)	gnl|CDD|273676	TIGR01536, Asparagine_synthetase_1, asparagine synthase (glutamine-hydrolyzing). This model describes the glutamine-hydrolysing asparagine synthase. A poorly conserved C-terminal extension was removed from the model. Bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis. Long-branch members of the phylogenetic tree (which typically were also second or third candidate members from their genomes) were removed from the seed alignment and score below trusted cutoff. [Amino acid biosynthesis, Aspartate family].	1.76487e-150
NZ_CP045178.1|WP_077966376.1|5578151_5578940_-|helix-turn-helix-domain-containing-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.50173e-05
NZ_CP045178.1|WP_077966385.1|5569836_5570481_-|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	2.63682e-18
NZ_CP045178.1|WP_152330866.1|5560797_5562366_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl|CDD|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	2.31609e-51
NZ_CP045178.1|WP_077966384.1|5571073_5571787_-|hemolysin-III-family-protein	gnl|CDD|367292	pfam03006, HlyIII, Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.	1.0956e-47

Protein sequences

>NZ_CP045178.1|WP_077966384.1|5571073_5571787_-|hemolysin-III-family-protein
MTAPGPEAIPDHAEATGGPTEIPLPALVKPKLRGWLHAGMFPAVLISGLALTALADSTRARVACGIYVLTACLLFGVSGLYHRGNWGPRAGGVLRRLDHANIFLIIAGTYTPLTMLLLPDSKGRWLLWGVWGAAAAGIIFRVFWVGAPRWLYTPCYIAMGWAALFFLPDFMRAGGVAVLVCVLVGGLLYSVGGVIYGLKRPNPSPRWFGFHEVFHSLTLAAFIVHYVGISLVAYQHA
>NZ_CP045178.1|WP_107502722.1|5570401_5570749_-|hypothetical-protein
MELLTSALRRGPPSESPLRPAGTGVAPSPVRLGRATSVLLAVMAQVPEFGRRLTEDGLGVKQWHPAEVPRSAPLCPWQPPEPRMADNEGHEGRSYPRPRHPGQQRPGQRPPAGTS
>NZ_CP045178.1|WP_077966385.1|5569836_5570481_-|TetR-family-transcriptional-regulator
MKAARTPVPDTRVSNAQDSAPRLGLRERKKIKTRQAIRGAAYRLIKERGYEATTVELIAEAAEFSMSTVFRYFPTKEDIVLTDEYDPMIESALRARPADESLVESMRQVMRQSFAAVIADDYDELVIRSTLMNEVPAVRSRMTEGMTATGRILCDVIADRLGRDPEELEIRSVTMGLIGALTETVLYWAQHGHKDDLADLVDRVLAPFSRGFEL
>NZ_CP045178.1|WP_077966386.1|5567729_5569766_+|thioredoxin-domain-containing-protein
MNRLADSQSPYLLQHASNPVDWWPWGPEAFEEAKRRDVPVLLSVGYSACHWCHVMAHESFEDERTAALMNDNFVNIKVDREERPDVDAVYMEAVQAATGQGGWPMTVFLTPDAEPFYFGTYFPPSPRHGMPGFPQVLDGVRAAWTDRRGEVDEVAGKVTRDLRGRALAFGDDLNVPGEAESAQALLGLTREYDASHGGFGGAPKFPPSMVIEFLLRHHARTGAEGALQMASDTAERMARGGIYDQLAGGFARYSVDREWVVPHFEKMLYDNALLCRAYAHLWRSTGSDLARRVALETADFMVGELRTLEGGFASALDADSDDGTGRHVEGAYYVWTPEQLRAVLGDEDARVAAAHYGVTEDGTFEEGASVLQLPQDEGVVDAERSESIRERLLAARAERPAPGRDDKVVAAWNGLAIAALAETGAYFDRPDLVDAAIGAADLLVRLHMDPRARLTRTSRDGRAGANAGVLEDYADVAEGFLALASVTGEGVWVEFAGFLLDIVLDQFTDSTGALFDTAADAEPLIRRPQDPTDSATPSGWSAAAGALLSYAAHTGAEPHRTAAEKALGVVKALGPRAPRFISHGLAVAEALLDGPREIAVVGGADDERTRALHRTTLLATAPGAVVAVGAPGSDETPLLVDRPLVDGAPAAYICRGFVCDAPVTDVVAVGERLGVRQV
>NZ_CP045178.1|WP_107502723.1|5563418_5567387_+|helix-turn-helix-domain-containing-protein
MLQEAWPPERLTYSGVAKELGVSRSTLRSWIEGKTVPSPDRLRDFLAVVARSQSGHSTPTYSDAEWEAASWAAKEEARGAQHSQISVNRRPADPRLRFIGLHGSAPEVSAAEVRVRANECTEMKAFAQDSRPGAPSYLCWHADGPVGKTTLLAGYVRQKPPTGSDILTFFVSAADGTDTRAEFEKEIAGQIDRLLGRTGSPVLKGIRAWNALFAKAAKKSACHGRNLLLVVDGLDDDVAWSGDVAGPGRADKSGAPKSMARSGGELEGPDRVVRRSARESIAALLPSLPPPNMRVIVSLRRCTPLPRDVPEKRHPLRQSRHLRTLLPIAGVPRLREPPPDAIALGKSVAGLLAVADGGLRVTDLAELTGLSADHLDRLVQGPAGRALVTEDPVLGTHALADSRLVRAVREEVGGAAVLRYTEELLLWSRRWRAAGWPDDTPPYPLADQLRLLTGTTERASYVLDLLRLRRLAHTAGPDIPLAQLDAFEKETGAATDVTSADRLAALTSLYGARSLLRQAHDTYVPDGAPALHVRLGDAKRARGLARSAPTAVDRAVHLADTAVELAYAGQPSVARAQNVDALVREAAEWLARDRAHQGFPGPLREPEPYVRLLCAAGTLARLNGPGAAQPLFRAVLQDPAAGTAAITEAAGKLNAVMTLYSRAETLSAGDLRARTAAVELYGALAQVAPYLGPYAGDRVEAVCEELSDTEELGAVDVLATAASVLVALPAKRHRRAAEQLRRARARTRRAIEALRDSDSLSDALSEADRAHLRRELAGTLERLAEATVAMKARGDHDGVRRQIEAVPEDQRVGILGDPLLERAQSILDAAGNERVRRAGEAAQEAAEKSETERKAKRRKADAERAELNEARITRGAQATRAPRPTRTEPEDTRASSPSRRPDPHRRSTGLLRPGDGPDPDRPEQPLLPLLLEVDDEVGAGRLLRGRELLAAALRSRPASQPVSTPYLPEGWTAELCQAMGVAGASDEAEAFVRHLPGTHARAWHLAALSLGCSLAGHDDPGTRHARAAARLLPTGAAPDLTNVVAQALAHARDEDAATAMVTGDTAQRLQALTAIAAGLVRHCPEAAERVAEPLVEVLARRMETGTPRVPLPELTALLLAFPDVRNPAPRLGDTLGRAVLRVAAPSMAAPERSMAVIALLERLRCLPDEAVNAAESSVGRWRRARQPGPQLSAELALLAAMNGDTVAVWRHADAARTPDDRSTALGTAAAHLAGAQVAPAADSGAHDRVIRTCLALARAVDHDSPSAEETARDIALELLQSDAWTRTIPLLPSLAPGALGHLTAMARDMTVLRRDSDVGPAT
>NZ_CP045178.1|WP_152330866.1|5560797_5562366_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MPAVDLDGATAHHSLSAVFNRADDLAALDCTSPGETVAVIEYLLAICFASGTCPSSDEDWNGWILWQRPLAPAAEWLVKQPADSWDLFHPTHPLVQNADLSKDLRKSGTGTAQLIIEHSGDYNQHFDHHHLERDNPLPAADAFRATLTQHVYGPYGRARMSGGELGARVTNLAAGRLTGRIRVVALGKTLGETLRLNLYPPDGPGQPLNTSWTTSVLKQRRFEEKRKPRAPRSSADLHSALGRSVLLRPARGSHGQLMVDRVLIGAGEVLDLDPARHLQDAVYSTTTNGVSKPLWPSPSRALWQQAHALYGAVNDGRGGMYARLRSLLPYRRPEAEEPDPETPQGAPYHLWAVGLLTNKALPVLWTHGAYPYAPGLAAHLYRASRRGSDIAEYLAQTLKNAAIVAAETAFPAMRAADEAGQVARLDARYGFWPAAEDPFLKLLDEVVDRGFEDDDPVSAPLVAYAMQLMITARTRLLQLLDTLPPGPYNFSRRLCPATRAVRLFEEAVSGDRAPAELRAALD
>NZ_CP045178.1|WP_077966388.1|5560250_5560805_-|hypothetical-protein
MTEQNPSAGTGAPGFPHDSAALTTWLTTLVRNREYGTLAELRRSRVRTNAHIRAGWYGGDDHRDLFERAAFLFAIYHQGRPTPSYGHGSLGAAARRIGDGTGRGPDNPGAQRLLDRVVASRRVPWRHLQHAITRLRSCEQPPPSWTTLTEDLIRWNDRKARIAYEWSVHFHTPPETAGKRGTNP
>NZ_CP045178.1|WP_077966389.1|5558842_5560315_-|CRISPR-associated-protein
MSGRSISTPLRKQPGSAERTHDVSDSSTSDFTDDSKGHHLVTEPPRSQFLSLHLIETLAAVLPVRDENGQPKSLVFGGVERHMITSQARRRAERVHARNRANAGLGELKGRSMGVRTREWALLAGRELESAHGWDRDRALVTARAVMEASGLKFGDPKKKTVANLTKVLIFAPSDAGAKIARHIVDRPAEVEEWRDAYLEAQARIEATRKTRRGARSKDTAEPDAEETPAETARAVALPPLPTATRDAVLLALAPRDAVDIALYGRFLAEIPDSPNVDGAVQTGHAFTVHEAEQIEDFYAAADDAKLDRKRNALDFLDAADDAGAGMTGYQSLISGTFYRHAVLDRKQLRVNLRVAGMDEAEAEQVASEAEKEFVNSFVEAFPEAKKNSTASTGSLPALVLAFEGERPYNYASAFQRPVDEGPLSTGGEGPAGPAAVRRLLRHHTFVSRRRGDLRTTRLLTYDPEIDLLLGELELPESLSVVERSEDLTP
>NZ_CP045178.1|WP_077966390.1|5557946_5558846_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSGTNDSHVLLIRLAGPLQSWGIAGRFARRDTHSRPTKSGVIGLCAAALGLSREEPLGELAEVRFGARADRPGTPLRDYHTVGGGKYPLRPRDLITDHQRAAKATTDSSPTPPEDDALEPGPFGRAELHAWYGSPKYVVADPRSGVLVSAEVRRHSLITERWYLADAAFLVGLEHQDRALLERVAHALEHPKRLLWLGRKACPPSGDLAVGIAPGSLKEVFETHSLLPDAVGPEAEPSATAQRLRPWAWIESKRPLPAVGPLSDQPVQFGADGGTHSLRWETHHRITIAEHARGWDIIL
>NZ_CP045178.1|WP_077966391.1|5557200_5557965_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MGHHPVNTNTTASDVSSGAGRAARFVAAQTLLTLDARHPFVGKSLIDAQDMHRTVMSGFPGWVDDGSPDPRARMGILSAWTVDLRQARLNLVVQSSLPADWSGIPRAARAERPEHLAVDRTFRFGDRVTFRTVVNPVHSVPPPPGSPPKTRGTRVPHTRPEHVKGWFVRRLQPPGEPAIAPDGVTRIGADADTDRIAVRMLPTVSSPAPHKGLRIARAEIKGTLTVTDPTAFVAALARGIGHARAYSCGLILVR
>NZ_CP045178.1|WP_077966383.1|5572033_5573230_-|amino-acid-ABC-transporter-substrate-binding-protein
MDTPPLPPSPPSPLSPPLGAGRTAEAGGAAEASRTAEASRTAKSAIRIGALVPLSRPGWVEAGRHLLAGLELGVREVNEAGGIAGSPLELVVRDTAADPGRAAAAVDELAGLGVAAVAGEYHSVVARAAAARADALGVPFLCSSAVLDALTDKPTEWVARLSPAQSHGWRIYTDHLVGEGHGRIAVATVPSAYWASGTRVLRDHLAPRGGTVIELDMRALSPEAVCDALVEHRATALLLLVGHPDPAVPIVKAVRRDRRLAGILVGAPAGQPEFAEWAALLGEDGAGVPFLRYLPERTTPLGARVGTALRERLAEPPSFVAFEGYDTIAVLADVLRSSGADRARGAESWPRVAVEGTRGKIRFSRTPGIDVWQWTWAPVQVVDRDPAEPDRFRVLHVG
>NZ_CP045178.1|WP_077966382.1|5573685_5575599_+|phosphoenolpyruvate-carboxykinase-(GTP)
MARDIAAPPLSGTLENSTGTLEAPRPAPDGGPAAPTGHRSLLAWVDEIAALTQPDRVVWCDGSAAEYERLCAELVSKGTFRKLDQGKRPNSYYAASDPTDVARVEDRTFICSAKEEDAGPTNHWKDPAEMREIFQGKDGREGVFRGSMRGRTMYVVPFCMGPLGSPLSAIGVEITDSAYVAVSMRTMTRMGSDVLRELGDDGFFVKAVHTLGAPLQEGEADVAWPCNPTKYISHFPEDREIWSYGSGYGGNALLGKKCYALRIASVMARDEGWLAEHMLILKLTPPEGEAKYVAAAFPSACGKTNLAMLEPTVPGWKVETIGDDIAWMRFGEDGRLRAINPEAGFFGVAPGTGEHTNANAMKTLWGNSVFTNVALTDDGDVWWEGMTEEAPAHLTDWKGNDWTPESGTPAAHPNARFTTPAAQCPIIAPEWEDPAGVPISAILFGGRRASAVPLVTESFDWNHGVFLGANVASEKTAAAEGKVGELRRDPFAMLPFCGYNMGDYMGHWVKVGADAVERGDGDKLPKIYYVNWFRKDDKGRFVWPGFGENSRVLKWIVDRLDGRAEGVDSPIGVLPAKGSFDTAGLDLSEADLDFLLKVDKEVWREEASLVPEHLNTFGDHTPKELWDEYRALVQRLG
>NZ_CP045178.1|WP_077966381.1|5575884_5576352_-|hypothetical-protein
MYEPIRSKSVHTLRGDLDEASFPHHSREEELDIQLAGYLAALLTVTDELRATSPGPSMDSAAEDLAHQITRLRRGHVPIRAAVTGEAGQKAHATRLHQRAHALAGRALVVAAARADTSAAILAAQRMDAHAAAERAAVAWQQQTEHGSKQLTPAG
>NZ_CP045178.1|WP_077966380.1|5576487_5577699_-|pyridoxal-phosphate-dependent-aminotransferase
MQLIQSTKLANVCYEIRGPVLEEAMRLESAGHRILKLNTGNPASFGFECPPEILEDILRNVSSAHGYGDAKGLLAARRAVVMHYQTLGVESDVENVFIGNGASELITMSMQGLLDDGDEVLVPAPDYPLWTAAVSLAGGTAVHYRCDEQSDWMPDLADVERRVTDRTKAIVIINPNNPTGAVYSDEMLRGLTDIARRHGLLVCSDEIYDKILYDGATHTPTAAIAPDLMTITFNGMSKAYRVAGYRVGWMVVSGPRAHASSYLEGLTILANMRLCANMPGQHGVVAALTGRQTITDLVLPGGRLMEQRDAAYDLLTQIPGVTCVKPKGALYLFPRLDPKVFKIKDDRQMVLDLLRKEKIMVVHGTGFNWPEPDHFRIVTLPSTEDLTEAVGRIGHFLDGYSQP
>NZ_CP045178.1|WP_077966378.1|5577912_5578155_-|DUF397-domain-containing-protein
MTDRLTWYKSSYSDDQGGACLEVALAWYKSSYSDAQGSNCVEVAAAPTHVHVRDSKRTDGPTFAVAAEAWTSFVTHTGNH
>NZ_CP045178.1|WP_077966376.1|5578151_5578940_-|helix-turn-helix-domain-containing-protein
MAWRYCGNQIKLWRTEAGGTREELASEANYDSEYVKSMEQGRRKPTVRLLRVADQLYGAKGKLEAGFDYLKPEPFPARTQQYMHAEAEALAIDWYEPLLIPGLLQNEQYAFALIGDSCPPLDDETVNERVEARLKRQALMIERASVAYGFMIYEAALRTGVGGKDVMKNQLNHLLALNELRNVTIQVVPEGRCNGLALMGSIVLLETPDHDRYAYSEVQTTSLLYADRAKVSELSQRHGMIQKHALTVGDSTECIRKVAEEL
>NZ_CP045178.1|WP_077966374.1|5579056_5579482_+|ATP-binding-protein
MNSTSSPPVGDIEFRMPRSRRSVGRARTLFTEQARCWKLPQGVTETAVLLLSELMTNAVVHAKVSQGREVWARCALRAEGTLRVEVLDADETPPTPRHASADDEGGRGLALIEALAERWGSEPREPGIGKTVWFELSVPGE
>NZ_CP045178.1|WP_077966371.1|5579497_5580061_-|DUF664-domain-containing-protein
MPWTAPQIIRTRTTDAEGQLNDPSDLAERELLDGWLRWHRETLLIKCAGLTGDELARTTASPSPLSLLSLVRHLAEIERWWFCRRFASQPLGEVFTGPDDGDEGIEGAEAAHAERDYTRYLSEVRSAEAAVAGHSLDETTFKSGAGRPVSLRWVYLAMIQEYARHNGHADLLRERTDGATGDYPGGR
>NZ_CP045178.1|WP_077966369.1|5580142_5580454_-|hypothetical-protein
MSDLKKDAESLHKAATALGKVEHHTRKPLHAFRAASHDLSAFGALGALMGAKDDIEEGMDTIAKFTRNLHKEWASEATFMGDVSDAFDLLDILLSAAARAKKG
>NZ_CP045178.1|WP_077966368.1|5580772_5582602_+|asparagine-synthase-(glutamine-hydrolyzing)
MCGITGWISYRRDLTGQQASLDAMTETMSCRGPDAQGSWVTPRAALGHRRLAVIDLPGGAQPMEARTDDGTVAMVYSGEAYNYRELREELRRRGHRFETDSDTEVVLRGYLQWGEELAGKLNGMYAFAIWDPRTEKLVMIRDRMGIKPFYFYETDDGVLFGSEPKAILANPLATAEVGPDGLREIFSFAKTPGVAVWEGMRELKPGHVAVLDRSGLREHAYWQLEVSEHTDSQQETVAHVRELLEDIIARQLVADVPRCSLLSGGLDSSAMTALAAKQLGEQGETVRSFAVDFPDQAENFRAMDISPTQDTPFVHAVKEHVRCDHKDIILDGAALSDPAVRRAAVGARDVPVGLGDRDNSLYLLFKAVREQSTVALSGESADEVFGGYPWFHDERREAETFPWLVGASPMDSTGVLAEDVARRLELGSYLQDSYASAVALTPLKEGEQGLEKRMRQVSYLHLTRMVQSLLDRKDRMSMAVGLEVRVPFCDHRLVQYVFNTPWSLKTFDGREKSILREATRDLLPESVVQRKKSGYPGSFDPRYVAAIQSQASELLSSGHAALELCNAGVLREAVAADGATITAQQRGHLERALDLAVWFDQHSPVIKFN

Crispr_ID: NZ_CP045178_18

• CRISPR_ID: NZ_CP045178_18
• CRISPR_location: 5717134-5717231
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_18

Consensus_repeat	Method
AGCCCGGAGCGGCCGGGTCGGAGA	CRISPRCasFinder

spacers of NZ_CP045178_18

>18.1|5717158|50|NZ_CP045178|CRISPRCasFinder
AGCCCGGAGCGGCCGGGTCGGAGAAGCCCGGAACGGGGCCGGGTCGCAGG

CRISPR arrays and Neighbor proteins around NZ_CP045178_18

CRISPR arrays

The CRISPR arrays of NZ_CP045178_18

>merge|NZ_CP045178|18|5717134-5717231|CRISPRCasFinder
AGCCCGGAGCGGCCGGGTCGGAGAAGCCCGGAGCGGCCGGGTCGGAGAAGCCCGGAACGGGGCCGGGTCGCAGGAGCCCGGAGCGGCCGGGTCAGGAG

>NZ_CP045178|18|14|5717134-5717231|CRISPRCasFinder
AGCCCGGAGCGGCCGGGTCGGAGA	AGCCCGGAGCGGCCGGGTCGGAGAAGCCCGGAACGGGGCCGGGTCGCAGG
AGCCCGGAGCGGCCGGGTCAGGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077966219.1|5725482_5726082_+|DivIVA-domain-containing-protein	unknown	unknown	gnl|CDD|274639
NZ_CP045178.1|WP_107502719.1|5704383_5705400_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966531.1|5723670_5724420_+|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl|CDD|224527
NZ_CP045178.1|WP_077966229.1|5717267_5718290_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP045178.1|WP_077966231.1|5716187_5717033_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|372582
NZ_CP045178.1|WP_077966215.1|5726720_5727521_-|enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|236163
NZ_CP045178.1|WP_077966535.1|5714290_5715394_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
NZ_CP045178.1|WP_077966237.1|5709813_5712018_+|hypothetical-protein	unknown	unknown	gnl|CDD|236090
NZ_CP045178.1|WP_077966223.1|5720315_5720756_-|ATP-binding-protein	unknown	unknown	gnl|CDD|227731
NZ_CP045178.1|WP_077966221.1|5724479_5725340_-|dihydropteroate-synthase	unknown	unknown	gnl|CDD|273657
NZ_CP045178.1|WP_077966243.1|5705563_5707690_-|S9-family-peptidase	unknown	unknown	gnl|CDD|366030
NZ_CP045178.1|WP_077966217.1|5726078_5726711_+|DNA-3-methyladenine-glycosylase-I	unknown	unknown	gnl|CDD|377025
NZ_CP045178.1|WP_107502732.1|5709286_5709640_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966241.1|5707851_5708046_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966227.1|5718432_5718753_+|ferredoxin-family-protein	unknown	unknown	gnl|CDD|224069
NZ_CP045178.1|WP_077966225.1|5718934_5720056_+|succinyldiaminopimelate-transaminase	unknown	unknown	gnl|CDD|236119
NZ_CP045178.1|WP_152330800.1|5715390_5716143_+|response-regulator	unknown	unknown	gnl|CDD|225107
NZ_CP045178.1|WP_077966533.1|5722443_5723550_+|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl|CDD|237264
NZ_CP045178.1|WP_077966235.1|5713385_5714126_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|223912
NZ_CP045178.1|WP_077966239.1|5708108_5709140_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	unknown	unknown	gnl|CDD|274584

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077966219.1|5725482_5726082_+|DivIVA-domain-containing-protein	gnl|CDD|274639	TIGR03544, cell_division_initiation_protein_DivIVA, DivIVA domain. This model describes a domain found in Bacillus subtilis cell division initiation protein DivIVA, and homologs, toward the N-terminus. It is also found as a repeated domain in certain other proteins, including family TIGR03543.	8.84761e-07
NZ_CP045178.1|WP_077966531.1|5723670_5724420_+|TIGR00730-family-Rossman-fold-protein	gnl|CDD|224527	COG1611, COG1611, Predicted Rossmann fold nucleotide-binding protein [General function prediction only].	5.59405e-55
NZ_CP045178.1|WP_077966229.1|5717267_5718290_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.86696e-09
NZ_CP045178.1|WP_077966231.1|5716187_5717033_-|tetratricopeptide-repeat-protein	gnl|CDD|372582	pfam13369, Transglut_core2, Transglutaminase-like superfamily.	6.35629e-42
NZ_CP045178.1|WP_077966215.1|5726720_5727521_-|enoyl-CoA-hydratase	gnl|CDD|236163	PRK08140, PRK08140, enoyl-CoA hydratase; Provisional.	3.37328e-75
NZ_CP045178.1|WP_077966535.1|5714290_5715394_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.58603e-39
NZ_CP045178.1|WP_077966237.1|5709813_5712018_+|hypothetical-protein	gnl|CDD|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	5.18738e-11
NZ_CP045178.1|WP_077966221.1|5724479_5725340_-|dihydropteroate-synthase	gnl|CDD|273657	TIGR01496, Dihydropteroate_synthase, dihydropteroate synthase. This model represents dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis. The gene is usually designated folP (folic acid biosynthsis) or sul (sulfanilamide resistance). This model represents one branch of the family of pterin-binding enzymes (pfam00809) and of a cluster of dihydropteroate synthase and related enzymes (COG0294). Other members of pfam00809 and COG0294 are represented by model TIGR00284. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	3.49527e-92
NZ_CP045178.1|WP_077966243.1|5705563_5707690_-|S9-family-peptidase	gnl|CDD|366030	pfam00326, Peptidase_S9, Prolyl oligopeptidase family.	1.59819e-47
NZ_CP045178.1|WP_077966217.1|5726078_5726711_+|DNA-3-methyladenine-glycosylase-I	gnl|CDD|377025	pfam03352, Adenine_glyco, Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.	8.97299e-97
NZ_CP045178.1|WP_077966239.1|5708108_5709140_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase	gnl|CDD|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	7.09179e-127
NZ_CP045178.1|WP_077966227.1|5718432_5718753_+|ferredoxin-family-protein	gnl|CDD|224069	COG1146, COG1146, Ferredoxin [Energy production and conversion].	8.52516e-12
NZ_CP045178.1|WP_077966225.1|5718934_5720056_+|succinyldiaminopimelate-transaminase	gnl|CDD|236119	PRK07865, PRK07865, N-succinyldiaminopimelate aminotransferase; Reviewed.	0
NZ_CP045178.1|WP_152330800.1|5715390_5716143_+|response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.1613e-64
NZ_CP045178.1|WP_077966533.1|5722443_5723550_+|succinyl-diaminopimelate-desuccinylase	gnl|CDD|237264	PRK13007, PRK13007, succinyl-diaminopimelate desuccinylase; Reviewed.	0
NZ_CP045178.1|WP_077966235.1|5713385_5714126_+|ABC-transporter-permease	gnl|CDD|223912	COG0842, COG0842, ABC-type multidrug transport system, permease component [Defense mechanisms].	1.31397e-11
NZ_CP045178.1|WP_077966223.1|5720315_5720756_-|ATP-binding-protein	gnl|CDD|227731	COG5444, COG5444, Uncharacterized conserved protein [Function unknown].	0.00370458

Protein sequences

>NZ_CP045178.1|WP_077966231.1|5716187_5717033_-|tetratricopeptide-repeat-protein
MNSAQPSPPSARWRERFAREARAERPDLSLLCLLIGAEADPDLDEAGLDAAQTELDRLAGLVPYRPGSPRAWAEALSGVLGSEYGFHGTPADYDRLGSSLLHVVLRRRRGLPILLSVVWMEVARRAGAPVHGVALPGHFVVGFGPPEDQVLADPFAGGRVLGEGEAGVLVKGATGGGLDAAMLSPAPALDVVRRVLNNITAWAAARPERTDVSLWSVELALLLPAHPAKLRYDRAQLLLRRGDFLTAAAEFEAYAEVVEGVSPEAAERLRGQGRRSRARLN
>NZ_CP045178.1|WP_152330800.1|5715390_5716143_+|response-regulator
MNTGTSANTEDDANTGTSANTEDDANTGTSANTGDEPAESVGDGARPGGPVRLLLAEDQSMVREALAALLGLEDDLEVVAQVARGDEVVEAVRENAVDVALLDIEMPGMTGLDAAEALHGEFPAVRIVVLTTFGRPGYLRRAMEAGADAFLVKDAPAAQLARAVRQVLAGEKVIDPTLAAAALAGGANPLTEREADILRAAEDGASNAELAAALHLSQGTVRNYLSTAIQKLAARNRAEAVRIARQKGWL
>NZ_CP045178.1|WP_077966535.1|5714290_5715394_+|sensor-histidine-kinase
MLWIGVWLVFFTDPVHDLLHQPRATGTAVWAWTGTAAFLVGYLMLVFRYTARPLAGAAGRLTLVGLFVLAVLLVGTLGESWLVLFVYVCVSIGATMPIGPANVLIPAAAAVMAGLALVVRANPGFGLIGSALLAGFAMTGVRRLVRTTVELRQARATVAQLAANEERLRLARDLHDLLGHSLSLITLKSELAGRMLPARVDDARQQVAEIEQVSRQALVDVREAVSGYRRPSLAGELAGAKSALGAAGIAADLPAQPPSRDLAPEREGVLAWVLREAVTNVVRHSGARRCTVTFAVRQTLDGPFLELRVADDGEGPSGAYYGNGLTGITERLTAAGGALETGSVFTARGRRGTGFLLTARVPLGSAP
>NZ_CP045178.1|WP_077966235.1|5713385_5714126_+|ABC-transporter-permease
MNALVKLEITRALRNKKFVFFSVLYPAGLFLLITAGQGNSTKVDGSGLGVPAFLMVSMASFGALTAVLMGNSERIAKEREKGWVRQLRLTALPGHGYVIGKIASAAVVSLPSIVVVFLVGAVVKGVRLDAWEWLALVGVIWAGSLVFAALGVAIGYVASGDAVRPLTMIIYFGLSVLGGLWMPTTVFPGWLRNIADWTPTHAYAGLGRAIELGNGPHLRDVLLLLVYLLVFAGGAARLYRKDTLKA
>NZ_CP045178.1|WP_077966237.1|5709813_5712018_+|hypothetical-protein
MSRETESSSSGPQGRGGAAYPSGTPPYGSPAQSDENERDAPGADASPRAAEPKAPGRPDERKTETTLTTRIRINIPGSRPIPPVVMRTPMGEGEQAEPITGPATPEPAAEPPAPEAEEKPPSDWFAPRKGGTRGGNTPLGGSGSTPAGGTPNGGAGTPTGGAPGRASGNGGAPGGGSEPNPGGSGAFDVSQALAAGPLGQGAKPPGAGRNGAGNRPSGPTGGPTTGDGPLVPSAYPPPGDTRPGGHPRDGGGPVGGPRAGDGAGAPWDGDATSQTRIGDTTGETRIGDTTGQAPIGDPFAEVRREQAAGRNWMGDDTAVLTPQGPSSSDPFGAGPGGPGSGPGAGQGPGSGSGDNISSSTLTSGIPVVPPLQGPGAGPYGQGDQGPFPPLGPGGPGGPARFPEPVSEPAPAASPPAKKAKKGGRKVTLAIGVVVVLAVVSYGAGLLMNHSDVPKGTTVLGVDIGGGTRDTAVNKLESSLDERTVAPLPLTVDGQKATLKPSQAGLTLDSQATVRAAATSDYNPVSVIGSLFGQKRVVQPDMPVDKEKLADALERVAGVSGSAHDGTITFSPGKATPVYGKPGQALDVDKSMTKVSDAYRAQVQSGKSAAVQLPVTTRKPTVPDSEVDRMMKEFAKPAMSGIVTIEAGGKSIPLGPDRSLPQILGVKAVDGKLTETYDRTALKKLYGNTFDGVLITRGTGKKTPVTPEDVVMAMRKALVGKTPTERIGVIETDPS
>NZ_CP045178.1|WP_107502732.1|5709286_5709640_+|hypothetical-protein
MAVYVLLLVVGAVTAVAGALVHAAWFPGGVLLALLAAAGVFYGGSCAMSAKAGAVVPAVGWLVTVFWLTSTRPEGDFVFGAGVLSYVFLLGGILVAVICATLARTAQPGGTAARLGK
>NZ_CP045178.1|WP_077966239.1|5708108_5709140_+|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha--D-glucopyranoside-deacetylase
MTELPGRRLLLVHAHPDDESINNGATMAAYAAGGAGVTLVTCTLGEEGEVIPPGLAHLAADRDDTLGPHRIGELAAAMRELGVTDHRFLGGAGRYRDSGMMGTAQNGRTGAFWNTPVEEAAAFLVEIVRETRPQVLVTYDPDGGYGHPDHIQAHRVAMRAAELAADPGYAPELGPAHTIEKIYWNRVPRSMAEDGFARIGESLPTTPFDAVAPLGEVPGVIEDSRITTEIDGRPHAAAKAAAMRAHATQITVSEPLFALSNGLAQPLFPVEAYELVRGRSGAADGEREADLFAGLAPPAGTGASAPVSHAEATGETERADETEATEAVDAVDARTPGAAGVTS
>NZ_CP045178.1|WP_077966241.1|5707851_5708046_+|hypothetical-protein
MALSISAVVLLAIVVFLLVKKSGLKGMHAVVCMLLGFYLASSSIAPTISKLTSNVAGMIGNIKF
>NZ_CP045178.1|WP_077966243.1|5705563_5707690_-|S9-family-peptidase
MTSEPISFPRGHARTQRFTLGAPRAFTVSPDGARVTFLRSRSGTDRANLLWVLDVDKGEERVAADPHRLLGGAAERLSAQERARRERSREGAAGVVGYATDQAALLAAFALSGRLFVTDLLTGEARGLSVPGPVIDPRPSPDGQHIAYVSRGTLRVVGADGADDRALAEPEAPTVTYGLAEHIAAEEMARTRGFWWSPEGDRLLVARADDAPVRRWWIADPANPAKQPAEIAYPAAGTPNADVRLFVLGLDGTRTEAVWNRDRYPYLARVHWSSAGAPLLLVQARDQRSQVFLAVDPETGATRMVHADEDPEWLELLPGVPAWTPEGRLVRIADEGGARVLAVGDRLLTGPQLHVRAVLDIGEQDLLITASAGESAAARETGEIHVYRVNELGVERVTREPGVHSAVRAGGVTLLSSATPGHPGTTVRVVREGREDHVVGSLAERPTLTPRVTLTEGGARKIPCAVLLPTHYREGDGPLPVLLDPYGGPHGQRVLAAYNPHLTSQWFADQGFAVVVADGRGTPGRSPAWEKAIKDRLAEVVLDDQIEALRGLADRFPLDLGRVAIRGWSFGGLLAGLAVLRRPDVFHAGIVGAPVTDQRLYDTHYTERYLGQPDEQPEVYRNSSLVDADGELVGAADEKRPMMIIHGLADDNVVVAHSLRFSSALLAAGHPHEVLPLSGVTHMTPQEQVAENLLLLQVDFLKRSLKLG
>NZ_CP045178.1|WP_107502719.1|5704383_5705400_+|hypothetical-protein
MGQPQTLARGARVLGSVICGLLALLSLGWIVRDLFEAAWPGQVWWMWAGTPSGYSGNGIWVTSLTDPVLLVICATAALRVPRSASAASALFAAGTAALVLRMPSVWMLNQDWIRLWGEGELRTEAQISAVTTVVLGAALLATAAIGRRPTGDPAPEHGAGTLPADGVRVPGRPRNVAAFCAALLLAVTAGILAAREVYDARDYGWTAYRNILLGSRNTTLSLLNTPHGWWMAALVLLALVAAGAALARATFSRALGLVTAGMVAAWGVLELSVAIKFHQFDAAVDAGLRYRLTLASTVYYLLAGVTVLVLLAPQRPGHGRDPADSWGTPSYGVPPTPS
>NZ_CP045178.1|WP_077966229.1|5717267_5718290_-|GNAT-family-N-acetyltransferase
MEFTVGGRLEVRINSSDVGKRVSVRSVVEPGHDGAKFTDTVGILTSWNDGVLLITRRTGDSVRIEETALVAGKPVPTAPARRRGPSATFPELARAQAGAWQPLESEGLGDWVLRASEGFTRRANSVLVAGEPGVPLDQALERVVDWYGRRGLPAYIQTSTGADSTHEVLSARLEERGWRREVSANVMVGPLAPLADAEDAARLDGVAMARQPDTHWLGRYNRASSAGAVSPGVLRVLGSGASTWFATVPGESPEASATAIGRCVVDGRWAGFAAVEVAAARRREGLASLVMAALARQALDEGASASWLQVESDNTGALALYDRLGFAVHHRYHHYRYMGS
>NZ_CP045178.1|WP_077966227.1|5718432_5718753_+|ferredoxin-family-protein
MTYVIAQPCVDVKDKACIEECPVDCIYEGQRSLYIHPDECVDCGACEPVCPVEAIFYEDDTPDEWKDYYKANVEFFDELGSPGGASKLGLIERDHPFVAALPPQNQ
>NZ_CP045178.1|WP_077966225.1|5718934_5720056_+|succinyldiaminopimelate-transaminase
MQEQQERAIVLAVSDLLPVFPWDKLESYKATAAAHPDGIVDLSVGTPVDPVPELVQKALVDGADSPGYPTVWGTPALRDAIVSWCERRLGAHGLTHHHVLPVVGSKELVAWAPTQLGLGPGDRVAYPRLAYPTYEVGARLARADHEVYDDPTELDPRGLKLLWLNSPSNPTGRVLSKDELTRIVAWAREHGILVLSDECYLELGWDADPVSVLHPDVCGGSYEGVVAVQSLSKRSNLAGYRAAFLAGDSAVLGELLKIRKHGGMMAPAPVQAAAAAALGDDVHVHEQRERYTARRTALRAALVEHGFTIEHSEAGLYLWATRGESCWDTVGHLAGLGILVAPGDFYGTAGERHVRVALTASDERVAAAVARLA
>NZ_CP045178.1|WP_077966223.1|5720315_5720756_-|ATP-binding-protein
MSLPLTRRIARAALLLAAGAAPVVGAAGSASAVELPASTDLGSVSALDGEGLGNTVDGAAQNVTGLAGQAGSQAVKQGVPAAGKVVGHAGKTAAPAAQKAAGGLAGTAGSLVGDTAKTATKGGLPTKGLGGGLPASSLGGLPLGGR
>NZ_CP045178.1|WP_077966533.1|5722443_5723550_+|succinyl-diaminopimelate-desuccinylase
MQETLLDLSLDAAELTARLVDLTSESGHEGPLADAVESALRALPHLTVDRHGNNVVARTDLGRSERVILAGHIDTVPIADNVPSRLDADGLLWGCGTCDMKSGVAVQLRIAATVPEPDRDLTFVFYDNEEVAAHLNGLGHVAEAHPDWLAGDFAVLLEPSDGQVEGGCQGTLRVLLRTKGERAHSARSWMGSNAIHAATPILNRLAAYEPRYPVIDGLEYREGLNAVKIEGGVAGNVIPDECTVTVNFRYAPDRTDEEALAHVREVFADCGVEEFVVDDHSGAALPGLSHPAAAAFIEAVGGTPQPKYGWTDVSRFSSLGVPAVNYGPGNPHLAHKRDEHVDTAKILLAEERLRWWLTGPAPLAGDGA
>NZ_CP045178.1|WP_077966531.1|5723670_5724420_+|TIGR00730-family-Rossman-fold-protein
MGSPEGQGRLEEQRLGSVVRRRDQVQSGTTDQRLLDSDGADTAWVHTDPWRVMRMQSELVDGFGALAELPRAISVFGSARTPVDSPEYAAGVRIGKALVDAGFVVITGGGPGAMEAANKGAREGEGVSVGLGIELPFEQGLNPHVDIGVNFRYFFVRKIMFVKYAQGFVVLPGGLGTLDELFEALTLVQTRKVTRFPIVLFGSAYWGGLVDWLRDTVVAQGKASENDLALFHVTDDVDEAVALVTKEVP
>NZ_CP045178.1|WP_077966221.1|5724479_5725340_-|dihydropteroate-synthase
MLRLGRREFAAHEPVVMAIVNRTPDSFYDQGATFRDEPALARVEQAVSEGAAIVDIGGVKAGPGEDVSAAEEVRRTVGFVAEVRRRFPDVVISVDTWRHEVGEVVCEAGADLLNDAWGGVDPKLAEVAARHGAGLVCTHAGGAEPRTRPHRVGYEDVVADILRVTLGLAERAVELGVARESVLIDPGHDFGKNTRHSLEATRRLDEMTTTGWPVLVSLSNKDFVGETLDRPVKERLIGTLATTAVSAWLGAQVYRVHEVAETRQVLDMVASIAGHRPPAVARRGLA
>NZ_CP045178.1|WP_077966219.1|5725482_5726082_+|DivIVA-domain-containing-protein
MVLFWFLVIALVVVVGAVTLAVLGGGEGAALPDAAPERLSDPLPDDRPVERADVESLRFPVTLRGYRMAEVDDALARVGAELAERDARITELETALTGAVGAAARGRGPGAAAAPLSGPYGREDAPYSYEQGGEADPYEQGGEPQPYEPRGASPSSGQQGGPEPRRYGQEGEPGRYERGSRGTSPRADERGDGTEGEQR
>NZ_CP045178.1|WP_077966217.1|5726078_5726711_+|DNA-3-methyladenine-glycosylase-I
MNTGTVEGPDGRLRCPWGLSAPEYLAYHDEEWGRRVHGDDALFERLSLEAFQSGLSWITILRRRENFRAAFAGFKIAAVAEFTGEDRERLLADAGIIRNRAKIDATLGNARALADWAPGELSTLIWSYAPAPGSLPAPRTTDDVPAITDESTALSGALKKRGLRFIGPTTAYALMQACGLVDDHLVACIARGAAGRAGKGGDRGAGPEKP
>NZ_CP045178.1|WP_077966215.1|5726720_5727521_-|enoyl-CoA-hydratase
MAETVLYDVADGLATITLNRPDAMNALNTEAKVALREAVLAAAGDKAVRAVLLTATGRAFCVGQDLKEHIGSLAADRASGSGSTMSTVAEHYNPIAKGLAGMRKPVVAAVNGVAAGAGFGFALAADYRIVADTASFNTSFAGVALTADSGISWTLPRLIGRSRATDLLLFPRGVKAQEAYELGIANQVVPAADLPARAVELAKSLAAGPTVAYAALKESLDFGASRTLDEALEKEDELQSLAGASEDHAIAVQAFIDKAAPHYLGR

Crispr_ID: NZ_CP045178_19

• CRISPR_ID: NZ_CP045178_19
• CRISPR_location: 5870718-5870809
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_19

Consensus_repeat	Method
CACCGATGTCGGGAGGTGCGGCC	CRISPRCasFinder

spacers of NZ_CP045178_19

>19.1|5870741|46|NZ_CP045178|CRISPRCasFinder
TACCGTGGTGCGGTGAAGCGGCCCACCGCCGTGCGATGAGGCGGCC

CRISPR arrays and Neighbor proteins around NZ_CP045178_19

CRISPR arrays

The CRISPR arrays of NZ_CP045178_19

>merge|NZ_CP045178|19|5870718-5870809|CRISPRCasFinder
CACCGATGTCGGGAGGTGCGGCCTACCGTGGTGCGGTGAAGCGGCCCACCGCCGTGCGATGAGGCGGCCCACCGATGTCCGGAGGTGCGGCC

>NZ_CP045178|19|15|5870718-5870809|CRISPRCasFinder
CACCGATGTCGGGAGGTGCGGCC	TACCGTGGTGCGGTGAAGCGGCCCACCGCCGTGCGATGAGGCGGCC
CACCGATGTCCGGAGGTGCGGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077966497.1|5868759_5869734_+|zinc-binding-dehydrogenase	unknown	unknown	gnl|CDD|176227
NZ_CP045178.1|WP_077966503.1|5867365_5868571_+|NADP-dependent-malic-enzyme	unknown	unknown	gnl|CDD|223358
NZ_CP045178.1|WP_077966021.1|5880984_5881668_-|spermidine-synthase	unknown	unknown	gnl|CDD|223498
NZ_CP045178.1|WP_107502714.1|5878874_5879969_-|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl|CDD|223715
NZ_CP045178.1|WP_077966505.1|5863895_5864648_-|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224051
NZ_CP045178.1|WP_077966038.1|5864686_5865622_-|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NZ_CP045178.1|WP_077966030.1|5870088_5870652_+|peptidase	unknown	unknown	gnl|CDD|214361
NZ_CP045178.1|WP_077966024.1|5874775_5878609_-|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	unknown	unknown	gnl|CDD|237030
NZ_CP045178.1|WP_077966028.1|5872074_5873103_-|DUF4097-family-beta-strand-repeat-protein	unknown	unknown	gnl|CDD|372574
NZ_CP045178.1|WP_152330803.1|5867127_5867370_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966031.1|5869879_5870089_+|HTH-domain-containing-protein	unknown	unknown	gnl|CDD|234647
NZ_CP045178.1|WP_077966042.1|5862276_5862906_-|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl|CDD|378696
NZ_CP045178.1|WP_077966036.1|5865736_5866711_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270225
NZ_CP045178.1|WP_077966026.1|5874423_5874609_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966019.1|5882428_5884846_+|endopeptidase-La	unknown	unknown	gnl|CDD|223542
NZ_CP045178.1|WP_077966027.1|5873523_5874378_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966040.1|5863007_5863769_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NZ_CP045178.1|WP_077966029.1|5870909_5872073_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367559
NZ_CP045178.1|WP_077966022.1|5880036_5880777_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
NZ_CP045178.1|WP_077966017.1|5886170_5887007_-|lysozyme	unknown	unknown	gnl|CDD|119374

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077966497.1|5868759_5869734_+|zinc-binding-dehydrogenase	gnl|CDD|176227	cd08266, Zn_ADH_like1, Alcohol dehydrogenases of the MDR family. This group contains proteins related to the zinc-dependent alcohol dehydrogenases. However, while the group has structural zinc site characteristic of these enzymes, it lacks the consensus site for a catalytic zinc. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	3.44931e-93
NZ_CP045178.1|WP_077966503.1|5867365_5868571_+|NADP-dependent-malic-enzyme	gnl|CDD|223358	COG0281, SfcA, Malic enzyme [Energy production and conversion].	7.16452e-179
NZ_CP045178.1|WP_077966021.1|5880984_5881668_-|spermidine-synthase	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	7.48318e-16
NZ_CP045178.1|WP_107502714.1|5878874_5879969_-|HAMP-domain-containing-histidine-kinase	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.33905e-47
NZ_CP045178.1|WP_077966505.1|5863895_5864648_-|amino-acid-ABC-transporter-ATP-binding-protein	gnl|CDD|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	5.98602e-154
NZ_CP045178.1|WP_077966038.1|5864686_5865622_-|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	6.05698e-77
NZ_CP045178.1|WP_077966030.1|5870088_5870652_+|peptidase	gnl|CDD|214361	CHL00095, clpC, Clp protease ATP binding subunit.	1.94598e-07
NZ_CP045178.1|WP_077966024.1|5874775_5878609_-|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0
NZ_CP045178.1|WP_077966028.1|5872074_5873103_-|DUF4097-family-beta-strand-repeat-protein	gnl|CDD|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	3.28412e-10
NZ_CP045178.1|WP_077966031.1|5869879_5870089_+|HTH-domain-containing-protein	gnl|CDD|234647	PRK00118, PRK00118, putative DNA-binding protein; Validated.	0.000588455
NZ_CP045178.1|WP_077966042.1|5862276_5862906_-|CGNR-zinc-finger-domain-containing-protein	gnl|CDD|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	2.2034e-13
NZ_CP045178.1|WP_077966036.1|5865736_5866711_-|ABC-transporter-substrate-binding-protein	gnl|CDD|270225	cd01004, PBP2_MidA_like, Mimosine binding domain of ABC-type transporter MidA and similar proteins; the type 2 periplasmic binding protein fold. This subgroup includes the periplasmic binding component of ABC transporter involved in uptake of mimosine MidA and its similar proteins. This periplasmic binding domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.03067e-77
NZ_CP045178.1|WP_077966017.1|5886170_5887007_-|lysozyme	gnl|CDD|119374	cd06412, GH25_CH-type, CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (acetylmuramidase) and diacetylmuramidase activity. The first member of this family to be described was a muramidase from the fungus Chalaropsis. However, a majority of the CH-type lysozymes are found in bacteriophages and Gram-positive bacteria such as Streptomyces and Clostridium. CH-type lysozymes have a single glycosyl hydrolase family 25 (GH25) domain with an unusual beta/alpha-barrel fold in which the last strand of the barrel is antiparallel to strands beta7 and beta1. Most CH-type lysozymes appear to lack the cell wall-binding domain found in other GH25 muramidases.	3.61008e-113
NZ_CP045178.1|WP_077966019.1|5882428_5884846_+|endopeptidase-La	gnl|CDD|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP045178.1|WP_077966040.1|5863007_5863769_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.97907e-18
NZ_CP045178.1|WP_077966029.1|5870909_5872073_-|PadR-family-transcriptional-regulator	gnl|CDD|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	3.51343e-21
NZ_CP045178.1|WP_077966022.1|5880036_5880777_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.13819e-82

Protein sequences

>NZ_CP045178.1|WP_077966030.1|5870088_5870652_+|peptidase
MFERFTQSAREVVTSAIEHSGRVGAGRVEPEHMLLALMDRKGTRAASALASLGISGEGRGAVETALEAARRRGGLSESDTEALAGLGIDLTRIVERVEAAHGVGALDGERRRARGGGRSRPFSREAKDVLARTLLITKGQGDRHIGDEHILLALVAGPGVVSDVLAKRGATYGAVHRALYGADGTRG
>NZ_CP045178.1|WP_077966031.1|5869879_5870089_+|HTH-domain-containing-protein
MTEATELAERTGDRDPRIGLRAVAALRRLLEQLEAVQVRSARNQGWSWQEIAAELGVSRQAVHKKYGRH
>NZ_CP045178.1|WP_077966497.1|5868759_5869734_+|zinc-binding-dehydrogenase
MFSVFAARIDREQPLNGLESGERPAPAERPGWTTVNVRAASLNHHDLWSLRGVGLGQAQLPMILGCDASGVDQDGNEVVLHSVIGETGHGVGPRERRTLLTEKYQGAFAEQVTVPTWNVLPKPPELSFAEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGRAAGLRVYVTSRDAGRRARAVELGALEAFEPGARLPQRVDAVIETVGAATWSHSIKSLRPGGTVVIAGATSGDRPSHAELTRVFFLELKIVGSTMGSKGEFEDLLSFCALTGVRPLVDETLPLDKAREGFEKLESGGQFGKIVFTVGQSS
>NZ_CP045178.1|WP_077966503.1|5867365_5868571_+|NADP-dependent-malic-enzyme
MDEKVKGSDNVATDQDNPLDHPAFPLHRGGKMAIQATVPVHDKDDLSLAYTPGVAEVCSAIAERPELVHEYTWKSKVVAVVTDGTAVLGLGDIGPEASLPVMEGKAILFKQFGGVDAVPIALATTDVDEIVETVVRLAPSFGGVNLEDIAAPRCFEIERKLQERLDIPVFHDDQHGTAVVTLAALRNAAKLTGRQIKELRAVISGAGAAGIAIAKFLLAAGIGDVAVADRKGIVSADRDDLTPVKRELAEITNHAGLSGSLESALDGADVYIGVSGGTVPEEAVASMAPGAFVFAMANPNPEVQPDIAHKYASVVATGRSDYPNQINNVLAFPGIFAGAFEVRASRITEGMKIAAAEALADVVGEEVSADYVIPSPFDERVAPAVTRAVAAAARAEGVARN
>NZ_CP045178.1|WP_152330803.1|5867127_5867370_+|hypothetical-protein
MWRGRERAHGGDTGRAQRDSSGRKDGYTPHPGLRARVRRVRAYVLRDGSPPVETWPRCPVCRTRRTRCPPVPQPGTVTLN
>NZ_CP045178.1|WP_077966036.1|5865736_5866711_-|ABC-transporter-substrate-binding-protein
MTANTTRHSGAAKSRIAAAGAIAVAGTLLLAGCGDQTKDDSGKDSGKKTGGGSSASAPLAGKLPKEIRDKGVVKVGSDIAYPPVEFKDKSGKTVGLDLDLATALGKQLGVEFQFENGTFDTLLTGLRSKRYDLAMSAMTDTADRQNGVDAETGKKVGEGVDFVDYFTAGVSIYTPKGKTQSIKTWDDLCGKKVVLQRGTVSDDLAKSQAKKCPAGKKLAIESYDNDQQAQTRLRAGGGDAGSSDFPVAAYAVKTSGGGKDFELVGEQVEAAPYGIAFAKSNTQLRDAVKAALDAIIENGEYDKIIAKWGVDAGKVTAAKVNGGK
>NZ_CP045178.1|WP_077966038.1|5864686_5865622_-|amino-acid-ABC-transporter-permease
MSADITKAGPEDAPPAGPQAIKAIPVRHYGRYIAAVVALALLVVIIYAFSQGKINWGAVPDYFFDSRILRGMEKTMLLTVLSMLIGVVGGVVLAVMRLSKNPVTSSIAWFYIWFFRGTPVLVQLFVWFNLGLVFEYVNLGPIYKDYWSSFMTPLLTALLGLGLNEAAYMAEICRAGLLSVDEGQTEASQALGMSHAKTLRRIVIPQAMRVIVPPTGNEVINMLKTTSLVAAVQYPELLRAAQDIGQTSGAPVEMLFVSAAWYLILTSVLSIGQFYVERYYARGSSRELPNTPFQKVRANLLSLGRPKGGMA
>NZ_CP045178.1|WP_077966505.1|5863895_5864648_-|amino-acid-ABC-transporter-ATP-binding-protein
MVKAEGVHKSFGNVEVLKGIDLEVANGEVFCLIGPSGSGKSTFLRCINHLEKINAGRLHVDGELVGYHQRGDKLYELKDSEVALRRRDIGMVFQRFNLFPHKTALENIMEAPVQVKGVSKAEARERAGQLLDRVGLADKADGYPSQLSGGQQQRVAIARALAMDPKLMLFDEPTSALDPELVGDVLDVMRGLAQDGMTMIVVTHEMGFAREVGDSLVFMDGGVVVESGHPRDVLTDPRHDRTKSFLSKVL
>NZ_CP045178.1|WP_077966040.1|5863007_5863769_+|class-I-SAM-dependent-methyltransferase
MSGTAIGTDWREWQESWDRQQEWYLPDREERFRIMLDMVEALAGPKPRVLDLACGTGSITDRLLKRFPEAVSTGVDLDPALLTIARGTFEGDDRVTFVTADLKDPDWTVLLPYDSYDMVLTATALHWLHTDALAVLYGQLAGVVREGGGFMNADRVVDAATPRINAAERAHRHLGMDRAKGEGVLDWAEWWQLAAADPVLAEPTARRYAIYGEHADGDTPSVEWHASALRAAGFDEARAVWASPSDALVLALK
>NZ_CP045178.1|WP_077966042.1|5862276_5862906_-|CGNR-zinc-finger-domain-containing-protein
MELAYYSDYAVRLVNTEEPARHRDSLTSVDSVRALFGTNASAGRRATDADVTRFRGVRARLRAVFEAADEGDPTLAVDLLNSLLLEFPVSPQISGHDHLDDEGDPRWHMHLADHPSNATAGFAAIAAMGLAFHLTEYGVDRLGLCEAAPCRNAYLDTSTNRSRRYCSDRCATRANVAAYRARKRLESDRSASTGRTAEKAQETSSTAER
>NZ_CP045178.1|WP_077966029.1|5870909_5872073_-|PadR-family-transcriptional-regulator
MAPVFAHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAGTVYPRLAKLEAEGLVTHTTEGGRKVYAITEAGRAELARRSGELAELELEIRESVAELAAEIRDDVRGAAGDLRREMRAAATRARQSSGPGQEHEKAASSEKETWRVAKEELRRAKLEWKEQARRAKDESRRAREETQQAKRQAKEAQEAAWEQAREARTQAQEEVQRIARRVQDQVQSHFARGDWPAGVRDGITELTKEFSRSGWPFSGSSPTGHGPTGTEWEDEQGADTPRAPGAASASPAEGPRDAAPGDGGRWFVKDEVPVDRIPATDDLDVTYQPSWAHETSSGDAARDLDRLLDRFRDDVRDTARDHGVTDEQLREARRHLSTAAAHIGSLLRSPTK
>NZ_CP045178.1|WP_077966028.1|5872074_5873103_-|DUF4097-family-beta-strand-repeat-protein
MPKWSVAEPTKLTFDDPVETLQVRVVGGAVNVVGTDDPHARLHVSEVTGPPLTVTHSGSKLTVVYEDLPWKGFLSWLDRMSRQRTAEVSLTVPAGTRVEVGVVGASATVSGITGHAEVKGVSGDTTLAGLSGPVRAETVSGNVEAQAVTGDLRFNSVSGDLTVVEGAGGSVRAESVSGDMIMDLGTGDRPTNVALTSVSGEIAIRLPHPADALVEANTTSGTVSNAFEDLRVSGQWASKKITGRLGSGSGKLKATTVSGSIALLRRPQATPDPDVEGAADAGTVAGSPGSGSQGPDGGAWGAVTDDVPQDSAGQRRTTEAGQTGATTQDDASGEAPNDKKVL
>NZ_CP045178.1|WP_077966027.1|5873523_5874378_+|hypothetical-protein
MPDVNRATEAGALLLCRAEPSVTGPAAHPLRESMLLLPAGAEWSVLVPEGKPWLHGGEPVDRVLTGWATALAVGSSWPVLALWWDHDRSGFVLAAGFRRTVAYEWLTNGTPVGEDEAMRTFAVRLGLDPVRDMASLKDLTRPDTGSDASARLRGLLAVLTRTGLTLPTGLAPGDPADRLRSVARIRPDVLHIEWAGWRDTVRAELGAVESRALGPWTRGPGARALAVTQLAAALPLIALGLRRRGVGWFFAGGLLVVQGALGLVYDRLRTDDGPRAEDATGTRP
>NZ_CP045178.1|WP_077966026.1|5874423_5874609_-|hypothetical-protein
MYFTDRGIEELAKRRGEEEVTFEWLTDQLRTFVDLNPDFEVPVERLATWLARLDDDEDEDE
>NZ_CP045178.1|WP_077966024.1|5874775_5878609_-|multifunctional-oxoglutarate-decarboxylase/oxoglutarate-dehydrogenase-thiamine-pyrophosphate-binding-subunit/dihydrolipoyllysine-residue-succinyltransferase-subunit
MSPQSPSNSTSTTTGQSGQDGQGPNPAAAFGPNEWLVDEIYQQYLQDPNSVDRAWWDFFADYKPGGAAATAKPAGDAPTGQSAPAPVGQAAGPAQTREAAPAAPAAAQSAPAPAAKQAQAPAQPAPAAKPAAAAPAKPAAAKPAAKQEPAAEAPEGPEYVTLRGPSAAVAKNMAASLELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKISFTHLIGYAMVQAIKAMPSMNNSFATKDGKPTLVKPEHINLGLAIDLVKPNGDRQLVVAAIKKAETLNFFEFWQAYEDIVRRARDNKLTMDDFSGVTVSLTNPGGIGTVHSVPRLMPGQAVILGVGAMEYPAEFQGTSQDTLNKLGISKVMTLTSTYDHRVIQGAASGEFLRIVANLLLGETDFYDEIFKSLRIPYEPIRWLKDIDASHDDDVTKAARVFELIHSYRVRGHVMADTDPLEYNQRKHPDLDIIEHGLTLWDLEREFAVGGFAGKTMMKLRDVLGVLRDSYCRTTGIEFMHIQDPKQRRWIQDRVERGHAKPEREEQLRILRRLNAAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVLDSAAEARLDEVVVGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPKSMHGSGDVKYHLGNAGTFTGLDGEQIKVSLAANPSHLEAVDPIVEGIARAKQDIINKGGTDFTVLPVQLHGDAAFAGQGVVAETLNMSQLRGYRTGGTVHIVINNQVGFTAAPESARSSMYATDVARMIEAPIFHVNGDDPEAVVRVGRLAFEFRQAFNKDVVIDLICYRRRGHNESDNPGFTQPLMYDLIDKKRSVRKLYTESLIGRGDITLEEAEQALQDFQGQLEKVFTEVREATTAPSAPEVPEPQAEFPVSVDTAISREVVKRIAESQVNIPDRVTVHPRLLPQLQRRAAQVEDDTIDWGTGETLALGSLLMEGTPVRLAGQDSRRGTFGQRHAVLVDRETGEDYTPLLYLSEDQARFNVYDSLLSEYAAMGFEYGYSLARPESLVMWEAQFGDFVNGAQTVVDEFISSAEQKWGQTSGVTLLLPHGYEGQGPDHSSARIERFLQLCAQNNMTVAMPTLPSNYFHLLRWQVHNPHHKPLVVFTPKSMLRLKAASSKTEEFTTGGFRPVIGDDSGTDPNAVRKIVLTSGKVYYDLEAERAKRGATDTAIVRVERLFPLPGKELQAEIAKYPNAEKYLWAQEEPANQGAWPFIALNLIDHLDLAVGADIPHGERLRRISRPHGSSPAVGSAKRHQAEQQQLLNDVFEA
>NZ_CP045178.1|WP_107502714.1|5878874_5879969_-|HAMP-domain-containing-histidine-kinase
MPAPGVGRLRPFSVKAKLATLVVTSVFITTGLLMVALRTDTELRFITVFSVIATLLITQFVAHGLTSPLAEMTTVARSISHGDYTSRVSGTGRRDELGDLASTINRMADDLEAQDHHRKELVANVSHELRTPIAALRAVLENVVDGVSEADPETMRTALKQTERLGRLVETLLDLSRLDHGVVPLRTQRFEVWPYLSGVLKEAQLPGTAAAQRGLVSRSGSHTRTDVHLHLDVSPPELTAHADVERLHQVVANLIDNAVKHSPPHGRVTVRARDGGTSGSLALEIMDEGPGIPRSEWHRVFERFNRGSSPKAHGPGSDGGTGLGLAIARWAVDLHGGRIGVAESSRGCRILVTLPGQASRNELT
>NZ_CP045178.1|WP_077966022.1|5880036_5880777_-|response-regulator-transcription-factor
MEQTHTSHSGAAATTPSAQRRVLVVEDDPTIVDAISARLRAEGFLVQTALDGPSAVDTAEAWQPDLLILDIMLPGFDGLEVCRRVQAQRPVPVMMLTARDDETDMLVGLGVGADDYMTKPFSMRELAARVHVLLRRVERAALAASTPRAGILRLGELEIDHAQRRVRVRGEDVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKALRRKIGAERIRTVHGVGYALETPTP
>NZ_CP045178.1|WP_077966021.1|5880984_5881668_-|spermidine-synthase
MIETCDHEAPVVLDRREGPYGEVVLRGHGGLLQIIANGTFLMDTSDGRSERLLVDAALGALDGRAAPSVLIGGLGVGFSLTHAAADPRWGRIVVVEREEAIIGWHRAGPLSALSERALGDPRTEILHTDLVGYLRRTTDTYDALCLDIDNGPDWTVDESNDGLYSPAGLASCHDRLTPGGVLAVWSARPSTAFEERVRNSGFHMVRTEEIVVARGVPDVVHLAIRAA
>NZ_CP045178.1|WP_077966019.1|5882428_5884846_+|endopeptidase-La
MASTSTPLTLPVLPLDDEVVLPGMVVPLDLSDSDVRAAVEAAQAASRAEGPTGAKPQVLLVPRIDGEYVGTGVLGSVEQVGRLADGDPGALIKGRRRMRIGAGTTGPGAALWVEATGLEESVPEPLPGAVTELVTEYKALATDWLKKRGAWQVVDRVQQIDDVSALADNSGYSPFLTTAQKVVLLETADPVKRLKIASAQLREHLAEQDVAESIAKDVQEGVDKQQREFLLRRQLEAVRKELRELGGQSGEDESDDYRTRVEAADLPEHVREAALKEVDKLERSSDQSPEGGWIRTWLDTVLELPWNERTEDAYDIRGARSVLDAEHAGLDDVKERITEYLAVRKRRADRGLGVVGGRRGGAVLALVGPPGVGKTSLGESVAHAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRVVRAIKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLEVELDLSDVVFLATANVLESIPEALLDRMELVRLDGYTEDEKVVIARDHLVPRQLERAGLASDELTVDESALRKLAGEYTREAGVRNLERGIARLLRKVAAQHELGQQELPFTVKDEHLRGFIGRPHHVPESAQDPAERRTAVPGVATGLAVTGAGGDVLFVEASLADPETGASGLTLTGQLGDVMKESAQIALSFLRSRGAELELPVADLKERGVHIHFPAGAVPKDGPSAGITMTAALASLLSGRQVRTDVAMTGEVSLTGRVLPIGGLKQKLLAAQRAGVTTVVIPKRNEADLDDVPAEVLDKLEVHPVTDVRQVLEIALAPAQASARVPAAA
>NZ_CP045178.1|WP_077966017.1|5886170_5887007_-|lysozyme
MPVHRSGTARHSRGRVAGILLAAVSLLVTLPAAAQANDTADLPVRGSAHLGMGVAEHDGRGPLPPDSRAAVQTEGVDVSSHQGSVNWATLWSSGVKWAYTKATEGTYYTNPSFAQQYNGSYNVGMIRGAYHFATPDTTSGATQANYFVDHGGGWSKDGKTLPGALDIEWNPYGAQCYGKSASAMVSWIADFLKTYKSRTGRDAVIYTATSWWSACTGNSAAFSATNPLWIARYNTTPGTLPAGWGFHTMWQYTSSGPTVGDHDKFNGALDRVKALANG

Crispr_ID: NZ_CP045178_20

• CRISPR_ID: NZ_CP045178_20
• CRISPR_location: 5895945-5896063
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP045178_20

Consensus_repeat	Method
CTGCCGTCCAAGGTCCCTGCCGT	CRISPRCasFinder

spacers of NZ_CP045178_20

>20.1|5895968|25|NZ_CP045178|CRISPRCasFinder
CCGAGCCCCAGTGCGGTCAGTGCCT
>20.2|5896016|25|NZ_CP045178|CRISPRCasFinder
CCATGGTCCCTGTCGTCCATGGTCC

CRISPR arrays and Neighbor proteins around NZ_CP045178_20

CRISPR arrays

The CRISPR arrays of NZ_CP045178_20

>merge|NZ_CP045178|20|5895945-5896063|CRISPRCasFinder
ATGTCGTCCGAGCCCCTTGTCGTCCGAGCCCCAGTGCGGTCAGTGCCTCTGCCGTCCAAGGTCCCTGCCGTCCATGGTCCCTGTCGTCCATGGTCCCTGCGGTCCAAGGTCCCTGCCGT

>NZ_CP045178|20|16|5895945-5896063|CRISPRCasFinder
ATGTCGTCCGAGCCCCTTGTCGT	CCGAGCCCCAGTGCGGTCAGTGCCT
CTGCCGTCCAAGGTCCCTGCCGT	CCATGGTCCCTGTCGTCCATGGTCC
CTGCGGTCCAAGGTCCCTGCCGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077966008.1|5892850_5893384_+|hypothetical-protein	unknown	unknown	gnl|CDD|214939
NZ_CP045178.1|WP_077965998.1|5899042_5900041_+|hypothetical-protein	unknown	unknown	gnl|CDD|370676
NZ_CP045178.1|WP_077966004.1|5893780_5894416_+|ATP-binding-protein	unknown	unknown	gnl|CDD|225138
NZ_CP045178.1|WP_077965997.1|5901618_5903052_-|FtsW/RodA/SpoVE-family-cell-cycle-protein	unknown	unknown	gnl|CDD|223843
NZ_CP045178.1|WP_077966019.1|5882428_5884846_+|endopeptidase-La	unknown	unknown	gnl|CDD|223542
NZ_CP045178.1|WP_077966011.1|5889410_5892854_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|340391
NZ_CP045178.1|WP_077966015.1|5887584_5888031_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NZ_CP045178.1|WP_077965989.1|5905608_5906802_+|Ku-protein	unknown	unknown	gnl|CDD|238408
NZ_CP045178.1|WP_077966013.1|5888213_5889062_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966021.1|5880984_5881668_-|spermidine-synthase	unknown	unknown	gnl|CDD|223498
NZ_CP045178.1|WP_077966000.1|5897386_5897704_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_107502713.1|5906821_5907244_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077966017.1|5886170_5887007_-|lysozyme	unknown	unknown	gnl|CDD|119374
NZ_CP045178.1|WP_077966495.1|5900164_5901622_-|penicillin-binding-protein-2	unknown	unknown	gnl|CDD|223839
NZ_CP045178.1|WP_077965991.1|5904678_5905566_-|ATP-dependent-DNA-ligase	unknown	unknown	gnl|CDD|240133
NZ_CP045178.1|WP_077965993.1|5903838_5904642_+|NERD-domain-containing-protein	unknown	unknown	gnl|CDD|377990
NZ_CP045178.1|WP_077966006.1|5893380_5893800_+|DUF742-domain-containing-protein	unknown	unknown	gnl|CDD|283084
NZ_CP045178.1|WP_077966002.1|5894484_5895723_+|oxygenase	unknown	unknown	gnl|CDD|380046
NZ_CP045178.1|WP_077966001.1|5896093_5897248_-|hypothetical-protein	unknown	unknown	gnl|CDD|366353
NZ_CP045178.1|WP_077965999.1|5897901_5898831_-|diiron-oxygenase	unknown	unknown	gnl|CDD|378680

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077966008.1|5892850_5893384_+|hypothetical-protein	gnl|CDD|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	3.32945e-13
NZ_CP045178.1|WP_077965998.1|5899042_5900041_+|hypothetical-protein	gnl|CDD|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	4.93106e-09
NZ_CP045178.1|WP_077966004.1|5893780_5894416_+|ATP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	7.55663e-41
NZ_CP045178.1|WP_077965997.1|5901618_5903052_-|FtsW/RodA/SpoVE-family-cell-cycle-protein	gnl|CDD|223843	COG0772, FtsW, Bacterial cell division membrane protein [Cell division and chromosome partitioning].	4.7614e-73
NZ_CP045178.1|WP_077966019.1|5882428_5884846_+|endopeptidase-La	gnl|CDD|223542	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones].	0
NZ_CP045178.1|WP_077966011.1|5889410_5892854_+|HAMP-domain-containing-protein	gnl|CDD|340391	cd00075, HATPase, Histidine kinase-like ATPase domain. This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.	2.5492e-19
NZ_CP045178.1|WP_077966015.1|5887584_5888031_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.27383e-17
NZ_CP045178.1|WP_077965989.1|5905608_5906802_+|Ku-protein	gnl|CDD|238408	cd00789, KU_like, Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku homologs are predicted to form homodimers. It is proposed that the Ku homologs are functionally associated with ATP-dependent DNA ligase and the eukaryotic-type primase, probably as components of a double-strand break repair system.	1.11144e-103
NZ_CP045178.1|WP_077966021.1|5880984_5881668_-|spermidine-synthase	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	7.48318e-16
NZ_CP045178.1|WP_077966017.1|5886170_5887007_-|lysozyme	gnl|CDD|119374	cd06412, GH25_CH-type, CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (acetylmuramidase) and diacetylmuramidase activity. The first member of this family to be described was a muramidase from the fungus Chalaropsis. However, a majority of the CH-type lysozymes are found in bacteriophages and Gram-positive bacteria such as Streptomyces and Clostridium. CH-type lysozymes have a single glycosyl hydrolase family 25 (GH25) domain with an unusual beta/alpha-barrel fold in which the last strand of the barrel is antiparallel to strands beta7 and beta1. Most CH-type lysozymes appear to lack the cell wall-binding domain found in other GH25 muramidases.	3.61008e-113
NZ_CP045178.1|WP_077966495.1|5900164_5901622_-|penicillin-binding-protein-2	gnl|CDD|223839	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane].	3.00987e-80
NZ_CP045178.1|WP_077965991.1|5904678_5905566_-|ATP-dependent-DNA-ligase	gnl|CDD|240133	cd04863, MtLigD_Pol_like, MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. MtLigD is monomeric and contains an N-terminal Pol domain, a central phosphoesterase module, and a C-terminal ligase domain. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The MtLigD Pol domain is stimulated by manganese, is error-prone, and prefers adding rNTPs to dNTPs in vitro. The MtLigD Pol domain has been shown to prefer DNA gapped substrates containing a 5'-phosphate group at the gap.	6.04683e-109
NZ_CP045178.1|WP_077965993.1|5903838_5904642_+|NERD-domain-containing-protein	gnl|CDD|377990	pfam08378, NERD, Nuclease-related domain. The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.	0.00115922
NZ_CP045178.1|WP_077966006.1|5893380_5893800_+|DUF742-domain-containing-protein	gnl|CDD|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	1.84092e-32
NZ_CP045178.1|WP_077966002.1|5894484_5895723_+|oxygenase	gnl|CDD|380046	pfam17885, Smoa_sbd, Styrene monooxygenase A putative substrate binding domain. This domain is found in the 46 kDa FAD-specific styrene epoxidase (SMOA) protein, comprises a part of the styrene monooxygenase (SMO) two-component flavoprotein monooxygenase enzyme. Structural analysis indicates that SMOA monomer comprises two globular domains spanned by a long alpha-helix. This domain contains a putative substrate binding site.	1.92176e-56
NZ_CP045178.1|WP_077966001.1|5896093_5897248_-|hypothetical-protein	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	4.77226e-23
NZ_CP045178.1|WP_077965999.1|5897901_5898831_-|diiron-oxygenase	gnl|CDD|378680	pfam11583, AurF, P-aminobenzoate N-oxygenase AurF. This family is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalyzing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes.	4.90117e-112

Protein sequences

>NZ_CP045178.1|WP_077966002.1|5894484_5895723_+|oxygenase
MRKLLVVGAGQAGLQIALGLQSHGYEVTLLSNRTADEIRAGRVMSTQCMFHTALQHERDLQLNFWESQAPDVEGLGLSVAGPDSGRAVDWLGRLDGIAQSVDQRVKMAGWMEIFAQRGGRLVIHGAAVSDLDYFARTYDLVLVSAGKGELVSMFERDASRSPYNAPQRTLSVAYVHGLGPRPEHPGLDAVRCNLVPGVGELFVMPAYTHTGRADILFWEGIPGGPVDAFKGIRDPSEHLSLTLELMEKYTPWEYARATKVELTDAGATLSGRYTPTVRKPVGRLPGGGAVLGVADVVVANDPVTGQGSNSAAKCAAAYLSAILEHGDKPFDEAWMQSAFDRYWETARPATEWTNAMLAPPPEHVLNIIGAAGSLPRVADRFANGFDDPADFDHFFYDPDKAAAYLESAAAEA
>NZ_CP045178.1|WP_077966004.1|5893780_5894416_+|ATP-binding-protein
MDSAGSDLLPPEAVLAADESLKPWQTDTTRAPIATKIVVAGGFGVGKTTLVTTVSEVTPLQTEALMTRAGEGTDDLSATPEKNTTTVAMDFGRITLDDDLVLYLFGTPGQQRFWFMWDDLVRGAIGAVVLADTRRLDDCFPALDYFESCGLPHVVAVNHFDGSELFEPADVREALTVPAHVPVLIMDARRRIPVIETLLTLVGHALDATPA
>NZ_CP045178.1|WP_077966006.1|5893380_5893800_+|DUF742-domain-containing-protein
MSTSGSPKLPTRGGARKPARVRPYSLTGGRTRFGHVLLVETFVAALDGPEARRGLTGGGSGGGGLSRIVPEMRAIVEVCRRMRTVAEIAALLRMPLGVVRVLLSDLADQGRIRVYGTGYGPGQPDRALLERVLGGLRRL
>NZ_CP045178.1|WP_077966008.1|5892850_5893384_+|hypothetical-protein
MTAPSRTPSTASSTPSAGERTPGVDGSSREARNLHWLLTNLVEEVPGLRSVAVVSSDGLLLLSSHPELNQPDTAQDTPGPRGASADLATIVSGLGSLCIGAADLMDGGRVTQTMVAMEEGSLFVMSISDGSLLGAHAAQDCDMSVVAYHMALFVGRAGHVLTPELRSELRQSMESAQ
>NZ_CP045178.1|WP_077966011.1|5889410_5892854_+|HAMP-domain-containing-protein
MQKTRPRGKGVTRAEGGKQGKSDTTAAPVEPRRYRVRSRLIIAVAVVAAAVAATGAPAVVSAGSDLRDSQRLVTLAGLTQRSVSLSQSLADERDEISSYIAAGRPHGEGLSERRSSRVDRQIDEIGADAPAGLRADLKEIGSVRRKALTGKGTALDAHTSYSEAIAKLHDIVEELADRMPPRAGSGAHALADLDDAVEQAGATRGLLLAALATPKPAGGTSIDPVTGMPSTESSEPTAAERRRDALSAQAQQARVRERSALADFAAGAAKEARGSYDSTVTGPEANTAETYLAKLTDQPTLSDAELKYDHDKVGSALSARIDLMRGVESALAADRAREVSRLRDEDVTALEIRIALTGVCLLIAVGVTIAVSRSLTHPLATLRLGTARVAADPIIEEPVRYTGRNDEFAQVVRSVNTMHEHAVTLYERISTLEADRKHLIGRRQSMADERQALREQLDEVGAQLETARGSIHGTFVNLALRTLALVERQLAVIEGLEEREQDPDRLATLFKLDHLATVMRRHSENLLVLAGAEHGQPHPGAVPLVDVLRAAVSEIERYERVRIAALPPHAHIAGVYADDLSHLLAELLENATSFSPPDAQVEVSGWRLESGEVMLSVQDQGIGMSESRLESANTLLSESDPEDMFPRTHEAGDRADGGLGLGLYVVARLAARHGVGVRLSEQKQGGTAAAVVLPEAILSDPSAGLALPGAGTQALGGTALVSLPGSEAEANSNVLYGRATDDTATGPVTPDDEDTSSERRCPGEDHTQEPPAAGHDPLIAAAEEAIRAAEKNAAAESVAEESAAEESAAAEYAAEESAERTDAERTDAGAVSVGEPGGSGESGEAAAAEVGAEDATDVDAAPEAEADAGNPTTSDTSEVTSEDTSEAAGTFAGNAPASEPVTSETTREFQAPTPDETAETDETADPAALTDPAAPTERNAAATTGLHAPSPYDIGPDRHERARDTDTARSRGQEDEAGDGERPSADGPALASGLPLRTGKGLPKRTPRITEPAPVPEPRSGGVDAEELRRRLDGFHQGAKKGRRDVEAAIAEETGTVPRARRAPEDEGRARVDAKEEGANSRTEESAGTEAGIRTAQDTAPTGTTGNTGTTGGGEESSLPADQAERTRATAARTGEAEGDTAEEARS
>NZ_CP045178.1|WP_077966013.1|5888213_5889062_-|hypothetical-protein
MRIELATDPGALERPNEDYTSVALPASGTGGSLVLLDGVTPPPDDTGCLHSVHWFTAHLGGKLGELSVSRRDLTLRDILGTAILHTADTHRDTCDLSHPRTPQATVVLVRWDDERVEYLVLSDSVLLLAGAEGEVEAVLDDRLDRLPERVGALRDATRALPVGSQERKETGRTYVAAVEALRNTEGGFHTAAADPSVADRAVTGVRPRAEVWAVAALTDGAGRFVETFDEGDWRDCFSVIAKEGPQSLIDRVRALEDAHLASGAAPVAWKAHDDAAVVYAEW
>NZ_CP045178.1|WP_077966015.1|5887584_5888031_+|MarR-family-transcriptional-regulator
MPGPLPELEFLALERELTVFLRRARASSGEMAREVHPELESAAYGLLVRLEEAGQQRATELAAYIGIGKATISRQLRALETLGLVAREPDPADGRAWLVHLTDEGRARYRSVRAARRARYVSRLSGWDRDEVAELARLLHQLNADAQG
>NZ_CP045178.1|WP_077966017.1|5886170_5887007_-|lysozyme
MPVHRSGTARHSRGRVAGILLAAVSLLVTLPAAAQANDTADLPVRGSAHLGMGVAEHDGRGPLPPDSRAAVQTEGVDVSSHQGSVNWATLWSSGVKWAYTKATEGTYYTNPSFAQQYNGSYNVGMIRGAYHFATPDTTSGATQANYFVDHGGGWSKDGKTLPGALDIEWNPYGAQCYGKSASAMVSWIADFLKTYKSRTGRDAVIYTATSWWSACTGNSAAFSATNPLWIARYNTTPGTLPAGWGFHTMWQYTSSGPTVGDHDKFNGALDRVKALANG
>NZ_CP045178.1|WP_077966019.1|5882428_5884846_+|endopeptidase-La
MASTSTPLTLPVLPLDDEVVLPGMVVPLDLSDSDVRAAVEAAQAASRAEGPTGAKPQVLLVPRIDGEYVGTGVLGSVEQVGRLADGDPGALIKGRRRMRIGAGTTGPGAALWVEATGLEESVPEPLPGAVTELVTEYKALATDWLKKRGAWQVVDRVQQIDDVSALADNSGYSPFLTTAQKVVLLETADPVKRLKIASAQLREHLAEQDVAESIAKDVQEGVDKQQREFLLRRQLEAVRKELRELGGQSGEDESDDYRTRVEAADLPEHVREAALKEVDKLERSSDQSPEGGWIRTWLDTVLELPWNERTEDAYDIRGARSVLDAEHAGLDDVKERITEYLAVRKRRADRGLGVVGGRRGGAVLALVGPPGVGKTSLGESVAHAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRVVRAIKEAGSMNPVVLLDEIDKVGSDFRGDPAAALLEVLDPAQNHTFRDHYLEVELDLSDVVFLATANVLESIPEALLDRMELVRLDGYTEDEKVVIARDHLVPRQLERAGLASDELTVDESALRKLAGEYTREAGVRNLERGIARLLRKVAAQHELGQQELPFTVKDEHLRGFIGRPHHVPESAQDPAERRTAVPGVATGLAVTGAGGDVLFVEASLADPETGASGLTLTGQLGDVMKESAQIALSFLRSRGAELELPVADLKERGVHIHFPAGAVPKDGPSAGITMTAALASLLSGRQVRTDVAMTGEVSLTGRVLPIGGLKQKLLAAQRAGVTTVVIPKRNEADLDDVPAEVLDKLEVHPVTDVRQVLEIALAPAQASARVPAAA
>NZ_CP045178.1|WP_077966021.1|5880984_5881668_-|spermidine-synthase
MIETCDHEAPVVLDRREGPYGEVVLRGHGGLLQIIANGTFLMDTSDGRSERLLVDAALGALDGRAAPSVLIGGLGVGFSLTHAAADPRWGRIVVVEREEAIIGWHRAGPLSALSERALGDPRTEILHTDLVGYLRRTTDTYDALCLDIDNGPDWTVDESNDGLYSPAGLASCHDRLTPGGVLAVWSARPSTAFEERVRNSGFHMVRTEEIVVARGVPDVVHLAIRAA
>NZ_CP045178.1|WP_077966001.1|5896093_5897248_-|hypothetical-protein
MSGRLLGLAVTAAVTTGSLLAPVHVAAAAPPPPGEQSVSALLTRLQGLYRNAEEATESYNAAEERLKKQRTGTELLGDRLAAARDSLRDSRSAAGRLARAQYQRDSGQYTPYLRMLMADDPRRALDVGHMIQRVARHRVNTVDRLARDERRRGELASAARKALAEKQRLAARQKSARDTVRDRLGEVEELLAGLSPGQIAQLAQLEQDGTAQAQRTFMASGALSHYRPPSARGARALEYAVAQIGKPYVWGAQGPDTYDCSGLTSQAWGRAGRRIPRTSQEQWATLPHVPLTELRPGDLVVYFPEATHVAVYLGDGQVVQAPRPGAKVKVSPVAANPVLGAVRPDPDAGPVPGWEPPRLPAGATAGDDTGYAGVGAPPRPKASG
>NZ_CP045178.1|WP_077966000.1|5897386_5897704_-|hypothetical-protein
MRSEDVPFAGGPLDGRVLPVLTGPTGRPPKLYKVPVPDPAGGPPTVLVYRLAPVSPSKRLGIPRGWRYDYLPEGPPSRERLRWPWTKPEPGAAPGGDTPVSPPAP
>NZ_CP045178.1|WP_077965999.1|5897901_5898831_-|diiron-oxygenase
MTTMTDVETLRDALGLLKDREQVAKRLLESSAKHSFDPDTELDWEAPPEEGKWYWPPELVSLYDTPMWHKMSEEQRMDLARHEAASLASLGIWFEIILMQLLVRHIYDKSVTSAHVRYALTEIADECRHSMMFARMIEKGGAPSYPVTRFNHNLARVLKTVSTTPGSFAATLLGEEILDWMQRLTFPDDRVQPLVRGVTRIHVVEEARHVRYAREELRRQMVSAPRWERELTRVSSGEAARVFSVSFVNPQVYTNTGLDRREAVAQVKASGHRREVMQSGAKRLTDFLDDIGVLQGVGRRLWKSSGLLA
>NZ_CP045178.1|WP_077965998.1|5899042_5900041_+|hypothetical-protein
MSTPPPPAPGDPGQQNPYAQPPQAPYGQQPGPPSPYGQQPGAPTPYGQQPGGPSPYGRPGPPAYGQQPGAPSPYGQQPGAPSPYGQQPGVPAYGQQPGTPPPPYGQPPYGQPYPGQPMGGPPPKKRRTGLILGIVGGVIVLFVIAGIVVATLVTGGSSFPEAKYRLTLPKQLLDGKYSLKQDMSDAEGKQIVDEADGSRDARNAKAVVGQYMSSSGGAVVVSGMYGQFKNTEAARRNMLKGAANAQGATVEVGVKDFKPAGSDVTISCQVMTSTGGAVKLTFPMCAWTDGNTGASVGEITTEATRQQPEDVDLEQAAQTAAKIRQEIRKPVE
>NZ_CP045178.1|WP_077966495.1|5900164_5901622_-|penicillin-binding-protein-2
MTPYIRRAAVLLVVLLAALLVNAVRIQIIQAGPYDGNPANRRHDIARYGQPRGDILVGGRPVTGSTDSGQRLRHERTYTNGPLYAPVTGFASQVYGTTFLENAEDGVLSGTDPMLATVPLWNDLSRTRSSGGDVVTTVRAAAQRAAYEGLGGRKGAVAAIDPSTGEILALVSSPSYDPGRLSGSGRKAADAWASLNAAKDKPMLNRAIRQTYPPGSTFKVVTAAAALDSGTVTDVDARTDSPDPYRLPGASTSLSNEVEGCADASLRYAFEWSCNTVFARLGVTTGARRMTRTAEGFGFNDSGVRIPSGVARSNFDTSPDKARLALSSIGQYNTRATPLQMAMVSAAVANGGSVPSPRLVERTATAGGTTVRQSGSRSLRQAMSAGTAARLRELMVDVVEGGTGRSAAIPGAQVGGKTGTAQHGVDNAGTPYAWFVSWAQAATDTVPAVAVAVVVEDASAVREDISGGGSAAPIARAVMRAVLKS
>NZ_CP045178.1|WP_077965997.1|5901618_5903052_-|FtsW/RodA/SpoVE-family-cell-cycle-protein
MTGTTGTAKAAEPTPAARLPRRRGTELALTVVAVLLCVLGYFDVGLTLHGVPPPGAAVYGAGLGVLALLAHLAVRWRAPYADPLLLPIGVLLNGLGLVLIYRLDLATPDDEAAPAQLVWSTIGVAFFIAVVVLLRDHRSLQRYAYLSMVAALALMIVPIFFPAVNGARIWVRAGGFSIQPGEFAKVLLAVFFASYLAANRHALAFAGRRIWLLRLPTGRILGPIVAIWLFSVGVLVLERDLGTSLLFFGLFVIVLYVATGRTGWVAVGLVLAAVGAFAAGSLEPHVNGRVEDWLHPLASIDAGRGPNQLAQSLFAFAAGGLLGTGLGAGHSVLIGFATKSDFILATAGEELGLAGLLALFLLYALLVERGYRTGLALRDPFGKLLAIGLASIVALQVFVIAGGVMGLIPLTGMAMPFLAQGGSSVVTNWIIVALLIRLSDSARRQPGEWAADPPGARNTRAPGPGAPAGLAGGGGPA
>NZ_CP045178.1|WP_077965993.1|5903838_5904642_+|NERD-domain-containing-protein
MTGLRVVPAVSHGQQRLHVCLPDGMTVAWFDRESARVHLIFESRRDDVLRALGPFLSGPVTVGPPPVPTPAELAGLALHPDDDLAPNRPGEALVIALDRDPAPSAGLRRDPRPRALAAERAIGESLDGLAGAGWRALHSIALPGGARIHHLLIGPGGLFCVRTLHAGGRRVRIDDPMVTVGRRTAVPELRRIRQDADRASFALAADVRPVLALVETARVEEAHGPRGIRVVTDADLTSLAHLAGVLKPADVESLYALARDRHTWLRL
>NZ_CP045178.1|WP_077965991.1|5904678_5905566_-|ATP-dependent-DNA-ligase
MTPITEVAGRRLSLSNLEKVLYPADGFTKGELLHYYATVEAALLPHLRDRPASFLRYPDGPDGQRFFSKNVPPGTPEWVRTAEVPHTEGPARQVVVQDLPTLMWAANLVTEFHTPQWRAENPGVADRLVLDLDPGAPATVVECCRVALLLRERLAADGLTAYAKTSGSKGLHLLVALEPTPSEQVTAYAKELAVEAERDRPESVVHRMTRSLRPGKVFVDFSQNAAAKTTATPYTLRAGREPTVSAPLTWEEVEACVQPEGLVVRAGDVPERLDRLGELLAPVVDGSAAAALPRT
>NZ_CP045178.1|WP_077965989.1|5905608_5906802_+|Ku-protein
MRSIWNGAISFGLVSIPVKLMNATENHSVSFRQVHLEDGGRIRYRKFCELEDKEVESAEIGKAFQDVDGTMIPITDEDLATLPIRTTKTIDIMAFVPADRIDPLQMDTAYYLAIGGAAAMKPYTLLREALSRSDRVAVTKFALRGKERLGVLRVVDDVIAMHGLLWPDEIRAPEDVAPDEGVTVRDAELDLAEALMDTLGEVDMADLHDDYREAVENMVAAKAEGAEPPARAESDSGGKVIDLMSALENSVKVAKKARDDGEPESEGPDADVHHIGGRKKRAPTSGEPIGSSGGRRAARTSPKDVSGKKSTSAAKKAPAKKDTASPSERTAGKHPAKGQQARKEPARKEPARKEPAKKEPAKKEPARKTASKGAASKGTAAKGTAAKKSAASGRRAS
>NZ_CP045178.1|WP_107502713.1|5906821_5907244_-|hypothetical-protein
MDGWLWLLIPGVIVGGGWIRENLQSALRTRHERKLELQHAAERRQVAVEAANKPPDPVCGCTHHLAKHDKLGKCHETVKAPVEWSGDDAPVRYEPRQCNCQQYIGPEPLATVFATELIDPSVNRLTKLPHTPRRSRDDSP

Crispr_ID: NZ_CP045178_21

• CRISPR_ID: NZ_CP045178_21
• CRISPR_location: 6053888-6054026
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_21

Consensus_repeat	Method
GCCGGTCGAGCCATCTGGTCGGACCGGGCCCGCCGCCGGTCGA	CRISPRCasFinder

spacers of NZ_CP045178_21

>21.1|6053931|53|NZ_CP045178|CRISPRCasFinder
ATCTGGTCGGACCGGGCCCGCCGCCGGTCGAGCCCTCCGGTGGGACCGAGCCG

CRISPR arrays and Neighbor proteins around NZ_CP045178_21

CRISPR arrays

The CRISPR arrays of NZ_CP045178_21

>merge|NZ_CP045178|21|6053888-6054026|CRISPRCasFinder
GCCGGTCGAGCCCTCCGGTGGGACCGAGCCGGCCGGTCGAGCCATCTGGTCGGACCGGGCCCGCCGCCGGTCGAGCCCTCCGGTGGGACCGAGCCGGCCGGTCGAGCCATCTGGTCGGACCGGGCCCGCCGCCGGTCGA

>NZ_CP045178|21|17|6053888-6054026|CRISPRCasFinder
GCCGGTCGAGCCCTCCGGTGGGACCGAGCCGGCCGGTCGAGCC	ATCTGGTCGGACCGGGCCCGCCGCCGGTCGAGCCCTCCGGTGGGACCGAGCCG
GCCGGTCGAGCCATCTGGTCGGACCGGGCCCGCCGCCGGTCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077968052.1|6039861_6040524_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077968273.1|6056648_6056861_+|EF-hand-domain-containing-protein	unknown	unknown	gnl|CDD|238008
NZ_CP045178.1|WP_107502811.1|6042972_6044844_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP045178.1|WP_077968064.1|6054498_6055284_+|polysaccharide-deacetylase-family-protein	unknown	unknown	gnl|CDD|213022
NZ_CP045178.1|WP_077968069.1|6059646_6060198_-|muramidase	unknown	unknown	gnl|CDD|279518
NZ_CP045178.1|WP_077968062.1|6053008_6053515_+|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NZ_CP045178.1|WP_077968068.1|6058847_6059561_+|NADP-oxidoreductase	unknown	unknown	gnl|CDD|224996
NZ_CP045178.1|WP_077968061.1|6051811_6052579_+|enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|236162
NZ_CP045178.1|WP_143621251.1|6045992_6047327_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077968065.1|6055283_6056534_+|YncE-family-protein	unknown	unknown	gnl|CDD|225926
NZ_CP045178.1|WP_077968073.1|6063374_6063977_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077968066.1|6056962_6057859_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|224044
NZ_CP045178.1|WP_077968055.1|6041020_6042976_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
NZ_CP045178.1|WP_077968072.1|6061937_6062840_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293835
NZ_CP045178.1|WP_077968051.1|6038696_6039716_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077968070.1|6060786_6060993_+|DUF3310-domain-containing-protein	unknown	unknown	gnl|CDD|371705
NZ_CP045178.1|WP_077968272.1|6047442_6049671_-|glycogen-debranching-protein-GlgX	unknown	unknown	gnl|CDD|131155
NZ_CP045178.1|WP_077968060.1|6050476_6051715_+|L,D-transpeptidase	unknown	unknown	gnl|CDD|380079
NZ_CP045178.1|WP_077968071.1|6060989_6061793_+|hypothetical-protein	unknown	unknown	gnl|CDD|365906
NZ_CP045178.1|WP_077968053.1|6040615_6040837_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077968061.1|6051811_6052579_+|enoyl-CoA-hydratase	gnl|CDD|236162	PRK08138, PRK08138, enoyl-CoA hydratase; Provisional.	2.32678e-76
NZ_CP045178.1|WP_107502811.1|6042972_6044844_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.20752e-144
NZ_CP045178.1|WP_077968064.1|6054498_6055284_+|polysaccharide-deacetylase-family-protein	gnl|CDD|213022	cd10917, CE4_NodB_like_6s_7s, Catalytic NodB homology domain of rhizobial NodB-like proteins. This family belongs to the large and functionally diverse carbohydrate esterase 4 (CE4) superfamily, whose members show strong sequence similarity with some variability due to their distinct carbohydrate substrates. It includes many rhizobial NodB chitooligosaccharide N-deacetylase (EC 3.5.1.-)-like proteins, mainly from bacteria and eukaryotes, such as chitin deacetylases (EC 3.5.1.41), bacterial peptidoglycan N-acetylglucosamine deacetylases (EC 3.5.1.-), and acetylxylan esterases (EC 3.1.1.72), which catalyze the N- or O-deacetylation of substrates such as acetylated chitin, peptidoglycan, and acetylated xylan. All members of this family contain a catalytic NodB homology domain with the same overall topology and a deformed (beta/alpha)8 barrel fold with 6- or 7 strands. Their catalytic activity is dependent on the presence of a divalent cation, preferably cobalt or zinc, and they employ a conserved His-His-Asp zinc-binding triad closely associated with the conserved catalytic base (aspartic acid) and acid (histidine) to carry out acid/base catalysis. Several family members show diversity both in metal ion specificities and in the residues that coordinate the metal.	8.36993e-46
NZ_CP045178.1|WP_077968069.1|6059646_6060198_-|muramidase	gnl|CDD|279518	pfam01183, Glyco_hydro_25, Glycosyl hydrolases family 25.	3.22024e-39
NZ_CP045178.1|WP_077968062.1|6053008_6053515_+|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	3.5125e-15
NZ_CP045178.1|WP_077968068.1|6058847_6059561_+|NADP-oxidoreductase	gnl|CDD|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	3.90668e-47
NZ_CP045178.1|WP_077968273.1|6056648_6056861_+|EF-hand-domain-containing-protein	gnl|CDD|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	7.30263e-12
NZ_CP045178.1|WP_077968065.1|6055283_6056534_+|YncE-family-protein	gnl|CDD|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	2.34072e-33
NZ_CP045178.1|WP_077968066.1|6056962_6057859_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	4.03326e-70
NZ_CP045178.1|WP_077968055.1|6041020_6042976_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	9.04214e-161
NZ_CP045178.1|WP_077968072.1|6061937_6062840_-|MBL-fold-metallo-hydrolase	gnl|CDD|293835	cd16277, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.2554e-99
NZ_CP045178.1|WP_077968070.1|6060786_6060993_+|DUF3310-domain-containing-protein	gnl|CDD|371705	pfam11753, DUF3310, Protein of unknwon function (DUF3310). This is a family of conserved bacteriophage proteins of unknown function.	3.15296e-07
NZ_CP045178.1|WP_077968272.1|6047442_6049671_-|glycogen-debranching-protein-GlgX	gnl|CDD|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
NZ_CP045178.1|WP_077968060.1|6050476_6051715_+|L,D-transpeptidase	gnl|CDD|380079	pfam17964, Big_10, Bacterial Ig domain. This entry represents a bacterial Ig-like domain found associated with transpeptidase domains.	8.48862e-71
NZ_CP045178.1|WP_077968071.1|6060989_6061793_+|hypothetical-protein	gnl|CDD|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	2.38203e-05

Protein sequences

>NZ_CP045178.1|WP_077968062.1|6053008_6053515_+|ATP-binding-protein
MAGLEGIEQARRPGSPAAPRWTPTVEDERALETMESHGNPVDAEVVLDSAPGAAATARRLAEIVVVAEWGLSPHLAECTALLVSELFGNAVEHTGARAVGLRMHRRPGRIRVEVRDPSRSLPCMMPAFEMEVVSGYGLLLVEKLSDRWGADLLPIGKKTWFEIRVSDR
>NZ_CP045178.1|WP_077968061.1|6051811_6052579_+|enoyl-CoA-hydratase
MTVHFEVAEGVGTIRLDRPPMNALDIAVQDRLKELAEEAGDRDDVRAVVLHGGEKVFAAGADIKEMRTMDHAAMVVRSKALQDSFTAVARIPKPVVAAVTGYALGGGCELALCADYRIAAEDAKLGQPEILLGLIPGAGGTQRLARLIGPSRAKDLIFTGRQVKAPEALALGLVDRVVPAGEVYAQAYAWAARLAKGPSLALRAAKEAVDTGLETDIDSGLALERTWFAGLFATEDKERGMRSFIEEGPGKAKFV
>NZ_CP045178.1|WP_077968060.1|6050476_6051715_+|L,D-transpeptidase
MSGRPISGASAGGGLPAGRRALPALLLGAMLLLTACGGGADGKGEGKGGGAGKAGAATPSQAVVTVAPKDGADSVGTSGALKIAADRGKLTSVRVADGKGNEVQGEITADGGKWTPEHHLASATKYKVHAIAKDSKGRESAKDTTFTTLVPKNTFVGTYTPENGSKVGVGMPVSLHFTRGITSPEAVEKAIEVTSEPKVEIRHKWYGNDRLDFRPEEYWKPDTKVTLQLALDGVEGRPGVYGKQTRTVTFTVGRSQVSTVDAKSHMMTVERDGKVLKKIPITAGGPGTTTYNGQMVISEKYQVTRMNGETVGFGGEYDIKDVPHAMRLSTSGTFIHGNYWAGASTFGSANTSHGCVGLRDTRGGYDGQAPAAWFYSQSLIGDVVTVKNSQDQTIPWWNGLNAWNLPWDKWEK
>NZ_CP045178.1|WP_077968272.1|6047442_6049671_-|glycogen-debranching-protein-GlgX
MLNGGRDGRRPLAEAVSVRSVWPGAPAPLGARFRTGPDGVAGTNFALWAGGAEAVDVCLFDDEGHETRCPLAESTHEIWHGFVPGVRPGQRYGFRVHGVWDPWTGGRWNRAKLLLDPYARAVDGEFTLPPEVYGHVRDWPQQHIADTVRDDRDSAPHVPKGVVVHDDAPDDEWKDDRRPKTPWADSVLYELHVRGFTRRHPDIPEELRGTYAGLAHPAAIGHLRRLGVTAVELLPVHQFAHEDHLLKRGLRNYWGYNSIGYFAPHAGYAAGGTRGQQVGEFRSMVRALHEAGIEVILDVVYNHTAEAGELGPTLSLRGIDNRGYYRLQDDARRYTDYTGCGNTLHVVRPQVLRLITDSLRYWVTEMGVDGFRFDLAATLARSLHDVDMLSPFLAVIAQDPVLRRVKLIAEPWDVGAGGYQVGAFPPLWTEWNDRYRDAVRDYWRDALPDVRDLGYRLSGSSDLYAWGGRRPQASVNFITAHDGFTLRDLVSYEHKHNEANGEGNRDGTGDNRAWNCGAEGESSRADINALRRRQLRNMLSTLLLSTGVPMLVAGDEMGRTQGGNNNAYCQDNETGWVDWSLLDEPGWHELYTLTARLIALRHRHPVLRRGAFFSGRASGVDGLRDLAWFTASGTEMTEDDWFAPAGTLGVYLSGARIAARDERGGRVTDDSFLAVLHSPAARAPFVLPGEPWARAYETVVDTSLEDQSVEPDAVLPAGSTVVLEGRSLLLFRVREPDPYGNP
>NZ_CP045178.1|WP_143621251.1|6045992_6047327_+|hypothetical-protein
MDSRARRGIRGRAGVLLALAPLLAVAACEGVPWEAGHPVYDEKPSAQLAAAAKVTKEAGTARFTSSLVYGDGATRATDTTTGVMDFTRDTASGERALRIPDALPAKDARALGATGSGDDLDRDIDEARAVRTSSVYVPVRSGERTSWLRFSKGERKKFGLTHSDLARLNGAGAPYGGTLAETLRGAKPTVRPEKLKGGMRRYHVTVSRTRSLKVLPVALARTIRADGEKPKVTVTVDLNKKGELRRATADLTPLLAALHRADVLTDVSVLRADYRLTRLGKWQEERFPSGHSVQRSERVIVPRSSLKPGQCADTGLVPAKKKRVLKVDCADPHGVRAYAKVSVDETVTKVHGDDLLTVHKDDLIKDYGHAACVDRLAKAPKNVTEDVAEPATVSSVGKQSLQLTKAHGTVVHAKAGKALPHGTRLKVTGDFTCLVRTDQSRTTG
>NZ_CP045178.1|WP_107502811.1|6042972_6044844_-|ABC-transporter-ATP-binding-protein
MDESHKPPAPVQRRSAVRALLRLWPYVRPVRVRLFGAAGVAVLASTAGLVIPLVLKHIVDGPVRHHDPGGVWIGALALLLLGLLEALLFGLRRWLVARPLAGVEASMRGDLYRHLQRLPIAFHDRWASGQLLSRGTTDLSLLRMFLAFPLTFLLVNGATILIGILILLAQDWTLGLVIVVPAIPLMVVCSIFERHYSLVARKAQDQVGDLTTLVEESVLGIRVIKGFGRHRSQAHAFRELSRTLRATELDKARLLAAIWGTITLLPELAIGVALVFGALRVADGGLSAGTLVAFLSTALALRWPVESIGFLLAMSQEASTAAERYFEVMDAPEEEPSPSADGAPATAEGGTPVEAQDGIRFERVAFRYPDAPDGSPPVLDGVDLHINSGETVAIVGATGSGKTTLTALVPRLHEIVSGRITLDGADITTMDRERLRSLVAVAFEEPTLFSASVAENILMGAGREAGETQLGRALEVAQAEFVHALPKGTGTEVGEQGLSLSGGQRQRLALARAVVGDPRFLVLDDPLSALDVHTEALVEAALRRVLAHTTALVVAHRPSTVMLADRVALLSGGRIAATGTHQELLRTSPEYAWLMSGAGAEDGGRRTALTTAGAGTRAEGNPA
>NZ_CP045178.1|WP_077968055.1|6041020_6042976_-|ABC-transporter-ATP-binding-protein
MTTQLPGGAQDTEDREAAHPVATAHRDDAEAPRDDGTPGETRSPVACTGSGTGTGTDPFDQDDLPTPRGATAALLRSLLAPMRARVVLSGVLLLVQQAAVQAGPLLVAYAIDSGVPAVREDRYGPLIAVAAGYFLCAVVSALLQYAFTKVSARVSQDVLLDIRGRIFRHAQSLSVDFHERYTSGRLISRSTTDVESLRELLNEGLQELITVALAFVYISAMLLWLDVGIGGLAVLSLVPLYLLVRLYQRRAGKMFARRSTAIAAVIVKFTETMNGIRPVRAFRRERANEAEFHLLNRHHERTNGDAILEMARYVTGSRLVANVAVAGLVLWGAYRVADGALALGVLAAAVLYLRRLYDPIDRLGMFLNSYQSAAASLQKIAGLLTQTPTVPEPAVPGELPPRATELPGREVVFEGVGFAYRTGGEVLPNFDLTLPAGQTVAVVGTTGAGKSTLAKLLARFYDPTRGRVLLDGVDVRELPMAELRRGVVMVTQEAFLFSGTVAENIAVGRPEASREEIERAAKAIGAHDFISSLPDGYDTDVRKRGGRISAGQRQLVAFARALLADPSVLILDEATSSLDVPGERAVQRAMDTVLRGRTAVVIAHRLSTVEIADRVLVMSHGRIVEDGPPQRLITESGAFAGLHEAWRESLA
>NZ_CP045178.1|WP_077968053.1|6040615_6040837_+|hypothetical-protein
MTGRSGEEEAALSPDELRMLESLTEVRGYSPRAQVAEPAQPPVGRASASPGAGPLDGPQADGESDETEPSPAD
>NZ_CP045178.1|WP_077968052.1|6039861_6040524_+|hypothetical-protein
MGQPPSTVFQLAVLVLFVLPGAVHQFLRERWRGPVPQERVLSERVLRALVASIVLDTAYAVAAGPELLRLVGVGGDGLTRAGLVGERIRWVGLWGLVLFVAVPAATAAAVSLLQRRHLRARYQSTPSAWDHVFRDRQPCFVRLRLKDGTWVGGWYGNESYATSYPQPHALHLESAWRMLGDGSFAERVEGTAGLHVSGTDVDIVEMVDAPTIAPGAPAEP
>NZ_CP045178.1|WP_077968051.1|6038696_6039716_-|hypothetical-protein
MTRFRELARRDPLAYENDFGLALYALCQETRKRPGPITQTFIDLCEEGIALHRRLLHTNPASRPQLTTLLVWLGVAQHSLGHHGKARPLFAESLDLARGSARRDPHLYEPELCRALALASFALSSSGDHHEALRAADDAVSRWRRLAAEQPDIHDAELAVALHTRCFAHQSAGNQQKMLEPAEESVRIVRRLHSTGTPSALASEMATGLDLVTAALLADDRWSEALPVAQESITWHGTKQNAEQGGRSLGLASSLGVYSMLLDKTGHRSEAKHYAQEAYVECLRRIRDTDAVADLAPVADQIGALLSGHGMKWSASMLRKGVAARLDTRRRGLRRFLRR
>NZ_CP045178.1|WP_077968064.1|6054498_6055284_+|polysaccharide-deacetylase-family-protein
MTTTDRRAALRAGVKLAAAGAFAAGCSAPPAERAPASSPTPTATARGKPAAAHAPAPRRFAGLPDQIDHSPRGRPEVALTFHGQGDPDIARTLLAKAENAGARLTVLAVGTWLDTHPGLARRILRGGHELGNHTQRHLSINDMSQAEARKEITACADRLHRLTGSIGGWFRPSRARTATPLVQRLARGAGYPHVLSYDVDSLDFTSPGSTAVVRNVMSTIHPGAVVSLHFGYRDTVDALPALLAELDRGGLRAVTTTELLT
>NZ_CP045178.1|WP_077968065.1|6055283_6056534_+|YncE-family-protein
MPYSPRTHRVPRAATLLCAALIAALAGCGGPGEPPGPRSPAADAGHDAGHGAGATAKSASPHGPAAAPTRAGSGALPGMPPLLDPKDVYAADRPGKLSPVVKDFPSRVYVPNTESDTVTVIDPATYKVIDTIPVGVQPQHVVPSWDLKTLWVNNNRGHSLTPIDPATGKAGKPVEVHDPYNLYFTPNGKYAVVMASLDRQLVFRDPHTMRRVKTEPVDCYGVNHADFSPDGRYFIVSCEFSGELLKVDTEKMKVVAHQKLPFKGAMPQDVKVSPDGRTYYIADMMADGVWVLDGDKFTTPKLMATGKGAHGLYISRDSREMYITNRGEGTISIFDFPADRLTKKWHLPDGGSPDMGGVSADGKVLWLSGRYDSEVYAVDTRSGKQLARIPVGNGPHGLAVYPQPGRYSLGHTGIFR
>NZ_CP045178.1|WP_077968273.1|6056648_6056861_+|EF-hand-domain-containing-protein
MADIEEARRAFERFDADGDGFITAAEWKTAMAQLGDWNVTESVAEAVIGAQDTNKDKLLSFDEFWAHLSK
>NZ_CP045178.1|WP_077968066.1|6056962_6057859_-|ATP-binding-cassette-domain-containing-protein
MTITQGTPAQDTHVQDTHVRDVSVEDVPTVLRAEDVDVVRAGNVLLHEVSLAVRPGEHWALLGANGAGKSTLLSLLGALTHPTKGKVEVLGHTLGRVDLRELRSYVGHVNPRHPLRSPLPVREVVLTGLTNSVERPPRWSPTAEQEERADRLISMLGLGSRGEARWPTLSQGERGRALIARALMPEPRLLLLDEPATGLDVAGREQLIDSIDALRVAHPELASILVTHHLEELPPGTTHALLLRAGRALASGPVDEVLTSDRISECFDHPVRLDRRDGRWSVRARRAAVVAEDRRVGQ
>NZ_CP045178.1|WP_077968068.1|6058847_6059561_+|NADP-oxidoreductase
MRRVPARRTPTDERRKATTMKIGIIGAGNIGSNLTRRFTAVGHEVALANSRGPETLDALAKETGATPVLAAEAARGARVVVVTIPLRAVADLPAALLDGAADDVVVIDTNNYYPYRDGRIAAIEEGLTESRWVAQQLGHTVIKAFNTIIASNIIDTARPRGSAGRVALPVAGDDEAAKRIVLDLVDEIGFDAIDAGGLDESWRQQPGTPSYGLSIDAEGIRRTLAEASPERSAEWRA
>NZ_CP045178.1|WP_077968069.1|6059646_6060198_-|muramidase
MLHGIDVSAYQASFDTDGIDFVFIKATEGRSYVSPKIAEQVKLARDAKCVVGFYHFLWPGNIDAQAEYFVKKTPEKAGDLLAVDWETTGEGTRASGAEKDKFIREVKKLRPDNRVLLYCNRSFWRTYDSTSYAGDGLWIADYVKAGEPRIEADWRIHQYKDSPLDTNVADFKDAAALRKWAKG
>NZ_CP045178.1|WP_077968070.1|6060786_6060993_+|DUF3310-domain-containing-protein
MVDDPVLFAWLLDGLETIDITSNFGFVRGNARTYLFRADFKRRTGEDLKKERWYIDHEIKLFEAEAGQ
>NZ_CP045178.1|WP_077968071.1|6060989_6061793_+|hypothetical-protein
MKRIVVISDTQMPYEDKRAMRNVINFIGEYQPDEVIQIGDLVDYPAPSRWTAGTREEFAGGVIRDSEYGRRVFLAPLRAVYDGPVKILKGNHDERPEKYLEKHAPALAADDVHYRFESLLDFDGFGVELAAPYYNFAPGWVAIHGHESPGLNQVAGRTAAMKAKKAGVSLVMGHTHRLAISPESTGFGGRLKTIYGFEVGHLMDVRKAGYLKNGPANWQKGFGLFYVGKYNATPHAIPVEHDGSFVVEGERFGEIKRGTNGKFTRAA
>NZ_CP045178.1|WP_077968072.1|6061937_6062840_-|MBL-fold-metallo-hydrolase
MRTSPAATSTPAWSVGDVTVHRVDEVALPPATGPWLLPDATPEVVTAQEWLRPHFAGGDGILHLDSHSFAFVVNGLRVLVDTGIGNGKERANPAWHNLRTDFLERLTAAGFPPDSVDLVILTHLHADHVGWNTQRVNGEWVPTFPQARYLTSRVEREFWATYDMEEAREQMFRDSVIPVEQAGLLRTVDVPHEGAKIAPGLRLIPTPGHTPGHVAVELTSQGQTALISGDCVHHPVQLAHPAIGACVDIDPRQSEATRRKVLGSLAGTDTLFLGTHFAPPTAGRVIAHEDAYRLEPAPAS
>NZ_CP045178.1|WP_077968073.1|6063374_6063977_-|hypothetical-protein
MGLLDTILGRSKPVRPDLDQLFAVPSAALTLQAGVGFTPTGLGSVCFAGVEGGNFARLRQDVRELLDADTGRGGAPVEFSEDSYGYTWLLARQPADDVAALVNDLHAVNTLLQDGGFGPHLLCSLIGFEDTRQRPLALVYLYKRGTFYPFAPRPGTGTRASEKRDNQLELQAKAALGDDLRMEQDLARWFPVWGAPGLTD

Crispr_ID: NZ_CP045178_22

• CRISPR_ID: NZ_CP045178_22
• CRISPR_location: 6194519-6194675
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP045178_22

Consensus_repeat	Method
CGCGCCGTGCGGCGCGA	PILER-CR

spacers of NZ_CP045178_22

>22.1|6194536|53|NZ_CP045178|PILER-CR
TGCCCGACCCCCTGCCCCCGCGCCGCACGGCGCGATGCCCGCACCCCTGCCCC
>22.2|6194606|53|NZ_CP045178|PILER-CR
CGCACACGCCTCCCACGTACCGCACGGAGCCGATCGCGCACACCGCCCCCCCA

CRISPR arrays and Neighbor proteins around NZ_CP045178_22

CRISPR arrays

The CRISPR arrays of NZ_CP045178_22

>merge|NZ_CP045178|22|6194519-6194675|PILER-CR
CGCGCCGTGCGGCGCGATGCCCGACCCCCTGCCCCCGCGCCGCACGGCGCGATGCCCGCACCCCTGCCCCCGCGCCGTGCGGCGCGACGCACACGCCTCCCACGTACCGCACGGAGCCGATCGCGCACACCGCCCCCCCACGCGCCGTGCGGCGCGC

>NZ_CP045178|22|3|6194519-6194675|PILER-CR
CGCGCCGTGCGGCGCGA	TGCCCGACCCCCTGCCCCCGCGCCGCACGGCGCGATGCCCGCACCCCTGCCCC
CGCGCCGTGCGGCGCGA	CGCACACGCCTCCCACGTACCGCACGGAGCCGATCGCGCACACCGCCCCCCCA
CGCGCCGTGCGGCGCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_152330810.1|6203351_6203765_-|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl|CDD|367422
NZ_CP045178.1|WP_077974572.1|6203775_6207363_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|377989
NZ_CP045178.1|WP_077968264.1|6201519_6201759_+|acyl-CoA-carboxylase-subunit-epsilon	unknown	unknown	gnl|CDD|379386
NZ_CP045178.1|WP_152330811.1|6207698_6208280_-|ATP-binding-protein	unknown	unknown	gnl|CDD|225138
NZ_CP045178.1|WP_077968243.1|6184501_6186298_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173842
NZ_CP045178.1|WP_152330808.1|6202034_6202616_-|ATP-binding-protein	unknown	unknown	gnl|CDD|225138
NZ_CP045178.1|WP_077968257.1|6197227_6198598_+|hypothetical-protein	unknown	unknown	gnl|CDD|372323
NZ_CP045178.1|WP_077968261.1|6199876_6201460_+|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl|CDD|130187
NZ_CP045178.1|WP_077968242.1|6183258_6183792_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379240
NZ_CP045178.1|WP_077968245.1|6186891_6188463_-|metallophosphoesterase-family-protein	unknown	unknown	gnl|CDD|277318
NZ_CP045178.1|WP_077968251.1|6191208_6192624_-|NAD-dependent-succinate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|143418
NZ_CP045178.1|WP_152330809.1|6202596_6203259_-|DUF742-domain-containing-protein	unknown	unknown	gnl|CDD|283084
NZ_CP045178.1|WP_077968259.1|6198849_6199464_-|YceI-family-protein	unknown	unknown	gnl|CDD|377274
NZ_CP045178.1|WP_077968249.1|6189905_6190991_+|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl|CDD|237363
NZ_CP045178.1|WP_077968247.1|6188592_6189633_+|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl|CDD|179579
NZ_CP045178.1|WP_077968253.1|6192994_6194323_+|MFS-transporter	unknown	unknown	gnl|CDD|340925
NZ_CP045178.1|WP_077968237.1|6178992_6180132_-|PucR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379258
NZ_CP045178.1|WP_077968239.1|6180331_6181258_+|proline-dehydrogenase	unknown	unknown	gnl|CDD|223580
NZ_CP045178.1|WP_077968255.1|6195004_6196660_+|citramalate-synthase	unknown	unknown	gnl|CDD|237068
NZ_CP045178.1|WP_077968240.1|6181455_6183087_+|L-glutamate-gamma-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|143441

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_152330810.1|6203351_6203765_-|roadblock/LC7-domain-containing-protein	gnl|CDD|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	5.96536e-23
NZ_CP045178.1|WP_077974572.1|6203775_6207363_-|HAMP-domain-containing-protein	gnl|CDD|377989	pfam08376, NIT, Nitrate and nitrite sensing. The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations. The NIT domain is predicted to be all alpha-helical in structure.	4.64775e-27
NZ_CP045178.1|WP_077968264.1|6201519_6201759_+|acyl-CoA-carboxylase-subunit-epsilon	gnl|CDD|379386	pfam13822, ACC_epsilon, Acyl-CoA carboxylase epsilon subunit. This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes.	3.22072e-08
NZ_CP045178.1|WP_152330811.1|6207698_6208280_-|ATP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	1.28618e-45
NZ_CP045178.1|WP_077968243.1|6184501_6186298_+|acyl-CoA-dehydrogenase	gnl|CDD|173842	cd01153, ACAD_fadE5, Putative acyl-CoA dehydrogenases similar to fadE5. Putative acyl-CoA dehydrogenase (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	3.34598e-179
NZ_CP045178.1|WP_152330808.1|6202034_6202616_-|ATP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	6.95092e-46
NZ_CP045178.1|WP_077968257.1|6197227_6198598_+|hypothetical-protein	gnl|CDD|372323	pfam12810, Gly_rich, Glycine rich protein. This family of proteins is greatly expanded in Trichomonas vaginalis. The proteins are composed of several glycine rich motifs interspersed through the sequence. Although many proteins have been annotated by similarity in the family these annotations given the biased composition of the sequences these are unlikely to be functionally relevant.	0.000194262
NZ_CP045178.1|WP_077968261.1|6199876_6201460_+|acyl-CoA-carboxylase-subunit-beta	gnl|CDD|130187	TIGR01117, methylmalonyl-CoA_decarboxylase_alpha-subunit, methylmalonyl-CoA decarboxylase alpha subunit. This model describes methymalonyl-CoA decarboxylase aplha subunit in archaea and bacteria. Metylmalonyl-CoA decarboxylase Na+ pump is a representative of a class of Na+ transport decarboxylases that couples the energy derived by decarboxylation of carboxylic acid substrates to drive the extrusion of Na+ ion across the membrane. [Energy metabolism, ATP-proton motive force interconversion, Energy metabolism, Fermentation, Transport and binding proteins, Cations and iron carrying compounds].	0
NZ_CP045178.1|WP_077968242.1|6183258_6183792_+|GNAT-family-N-acetyltransferase	gnl|CDD|379240	pfam13527, Acetyltransf_9, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	4.0535e-10
NZ_CP045178.1|WP_077968245.1|6186891_6188463_-|metallophosphoesterase-family-protein	gnl|CDD|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.59767e-34
NZ_CP045178.1|WP_077968251.1|6191208_6192624_-|NAD-dependent-succinate-semialdehyde-dehydrogenase	gnl|CDD|143418	cd07100, ALDH_SSADH1_GabD1, Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like. Succinate-semialdehyde dehydrogenase 1 (SSADH1, GabD1, EC=1.2.1.16) catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde (SSA) to succinate. SSADH activity in Mycobacterium tuberculosis (Mtb) is encoded by both gabD1 (Rv0234c) and gabD2 (Rv1731). The Mtb GabD1 SSADH1 reportedly is an enzyme of the gamma-aminobutyrate shunt, which forms a functional link between two TCA half-cycles by converting alpha-ketoglutarate to succinate.	0
NZ_CP045178.1|WP_152330809.1|6202596_6203259_-|DUF742-domain-containing-protein	gnl|CDD|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	7.26572e-47
NZ_CP045178.1|WP_077968259.1|6198849_6199464_-|YceI-family-protein	gnl|CDD|377274	pfam04264, YceI, YceI-like domain. E. coli YceI is a base-induced periplasmic protein. The recent structure of a member of this family shows that it binds to poly-isoprenoid. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	5.50881e-61
NZ_CP045178.1|WP_077968249.1|6189905_6190991_+|branched-chain-amino-acid-aminotransferase	gnl|CDD|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0
NZ_CP045178.1|WP_077968247.1|6188592_6189633_+|3-isopropylmalate-dehydrogenase	gnl|CDD|179579	PRK03437, PRK03437, 3-isopropylmalate dehydrogenase; Provisional.	0
NZ_CP045178.1|WP_077968253.1|6192994_6194323_+|MFS-transporter	gnl|CDD|340925	cd17367, MFS_KgtP, Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters. This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	0
NZ_CP045178.1|WP_077968237.1|6178992_6180132_-|PucR-family-transcriptional-regulator	gnl|CDD|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	1.35404e-20
NZ_CP045178.1|WP_077968239.1|6180331_6181258_+|proline-dehydrogenase	gnl|CDD|223580	COG0506, PutA, Proline dehydrogenase [Amino acid transport and metabolism].	2.83946e-55
NZ_CP045178.1|WP_077968255.1|6195004_6196660_+|citramalate-synthase	gnl|CDD|237068	PRK12344, PRK12344, putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional.	0
NZ_CP045178.1|WP_077968240.1|6181455_6183087_+|L-glutamate-gamma-semialdehyde-dehydrogenase	gnl|CDD|143441	cd07123, ALDH_F4-17_P5CDH, Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17. Delta(1)-pyrroline-5-carboxylate dehydrogenase (EC=1.5.1.12 ), families 4 and 17: a proline catabolic enzyme of the aldehyde dehydrogenase (ALDH) protein superfamily. Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), also known as ALDH4A1 in humans, is a mitochondrial homodimer involved in proline degradation and catalyzes the NAD + -dependent conversion of P5C to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Also included in this CD is the Aldh17 Drosophila melanogaster (Q9VUC0) P5CDH and similar sequences.	0

Protein sequences

>NZ_CP045178.1|WP_077968253.1|6192994_6194323_+|MFS-transporter
MERQQWKKIWVGSAGNMVEWFDWFVYASFATYFAGSFFPSGDSTAQLMNTAGIFAVGFFMRPVGGWLLGRIGDRKGRKAALTLTVSLMSASAVLIAVAPTYGVAGYGGAVVLLVARLLQGLSVGGEYAASATYLTEASAPSRRGFASSFQYVSMTAGQIVGLGLQIILQRTMSDDALHSWGWRIPFIVGALGAAVVFYLRRSMLETEVYEASADDTHDADKGTIKALWAHKREAFLVVALTMGGTVAYYTYTTYLTKYLSNSAGLPKQTATLVSFCALIVFAAIQPLAGMVSDRIGRRPLLITFAVGSTFLTVPIMTMLKHAGSFWPALGLSLLALVVVTGYTSINACVKAELFPTGIRALGVALPYAIANALFGGTAEYVALWFKNAGIEGGFAWYVAGCAAVSLIVYLLMRETRELDLNKVSTPASASASASVSTVTTSG
>NZ_CP045178.1|WP_077968251.1|6191208_6192624_-|NAD-dependent-succinate-semialdehyde-dehydrogenase
MPKQSKQTFATVNPYNGETVAEYPMIEGAEVDARVDGAHRAFGTWRERTAEERGAVVGRAAELMRDRKEELAGLITLEMGKLIGESRGEVDLAASILAYYGEKGPGFTKPEPLDVGEGEAYIKHEPVGVLLGVMPWNFPLYQVVRFAGPNLVLGNTVMVKHAANCPQSALALEKLFVDAGAPEGAYTNLFMNHDEVARVIGSPHVRGASLTGSERAGSALAEAAGRNMKKSLLELGGSDAFIVLDAENLDRTVGAAVAARLGNTGQSCVAAKRFIVLDEAYDAFVEGMRAAFARLVPGDPAAETTTLGPLSTEKAAADLVRQIQDTVDQGATVVIGGGRLDHPGAFVEPTILADVAPGMRAYAEELFGPAAVVYRVADEDEAVALANDSEFGLGGSVFCADVERARKVAERVETGMIWVNHPTGTQPDLPFGGIKRSGYGRELSALGMREFVNQKLVRVLPPDATMGGIAG
>NZ_CP045178.1|WP_077968249.1|6189905_6190991_+|branched-chain-amino-acid-aminotransferase
MTTPTIELKPTARPLSDTEREAILADPGFGRFFTDHMVTIRWTEGRGWHDAQLEPYAPLSMDPANMTLHYAQTIFEGLKAYRRPDGTVASFRPRANAERFQTSARRLAMPELPVETFIEACDALVQQDKAWVPAHGESSLYLRPFMIATENGLGVKPANEYLFLVIASPAGAYFSGGVKPVSIWLSEDRVRAVPGGMGDAKTGGNYAASLLAQAEAAEKGCEQVAYLDAVEHKWVEELGGMNLYFVYGNKIVTPSLTGSLLPGITRDSLLTLARDLGYEAEEARVSIDDWKNHTADGSLTEVFACGTAAVITPVGLVKSAGAEWTQGDGEPGKVTMRLREALLGLQTGAESDTHGWMHELG
>NZ_CP045178.1|WP_077968247.1|6188592_6189633_+|3-isopropylmalate-dehydrogenase
MSRSINLAVIPGDGIGQEVVAQGLKVLNAALPQDVKLETKEYDLGAQRWHRTGETLPDAELEALKNHDAILLGAIGDPSVPSGVLERGLLLKLRFAFDHFINLRPSKLFPNTESPLAGNPDIDFVVVREGTEGPYTGNGGSLRTGTPAEVATEVSLNTAYGVERVVRDAFERADSRPRKKLTLVHKTNVLVYAGHLWKNTFDKVAEEYPDVTTDYLHVDAATIFLVTDPGRFDVIVTDNLFGDILTDLAAAVSGGIGLAASGNVNPTGDFPSMFEPVHGSAPDIAGQGKADPTATVLSVALLLRHLGYEDRAVRIEDAVSADLAERDGTPRTTDEIGDALAVRVAG
>NZ_CP045178.1|WP_077968245.1|6186891_6188463_-|metallophosphoesterase-family-protein
MDTPRVGIPDQLAARMTMPEQHEYLRAKFSRRGALRTGTVAAGAVAGAGLLGGSASATPLPQAPAFLKTASAASHVDGSLVAPFGRHLAFGADPRTEMTVSWQVPLAVKRPFLRVGTKPWDLSRKIEAEVRHLHTPALTSKLPAVDQYYLHASMERLRPDTTYYYGVGHQGFDPADSRNYGTVGTFRTAPARPENFTFTAFGDQGVSYHALANDQLILGQDPRFHLHAGDICYADSSGSGSASDTYDARVWDQFLSQTESVAARVPWMVTTGNHDMEAWYSPNGYGGQNARWTLPGGGLDETKSPGVYSFVYGNVGVVALDANDVSYEIKANLDYTGGAQTRWLDRKLRELRRRADIDFVVVFFHHCAYSTTNAHASEGGVRDAWVPLFDRHKVDLVINGHNHVYERTDALRGGAVARRVPSGESVSSQRDGIVYVTAGGAGKALYDFPAPDSYEGHEHHVDSVDTYHTQKDGKKTETVEWSRVRYTGFSFLAVEVTTGRRPELKVTALAESGERVDHFTIKH
>NZ_CP045178.1|WP_077968243.1|6184501_6186298_+|acyl-CoA-dehydrogenase
MTSLLLSRRDLSFLLHEWLHVEELTKRPRYAEHDRETFDAALELSETIATRHFAPHNKKNDAREPTFDGERVHIIPEVSEALKVFAESGLTGAGMDEAVGGMQLPRVVTDACFAWFQAANAGTSAYPFLTVGNANLLLAHGSAEQIDRYVRPMVDGRYFGTMCLSEPQAGSSLADVRTRAERAEDGTYRLFGNKMWISGGDHELSENIVHLVLARIPGGPPGVKGLSLFVVPKYLVGDDGARGERNDVVLAGLNHKMGFRGTTNTLLNFGEGTHRPSGAPGAVGHLVGEEHRGLAYMFHMMNEARIGVGLGATALGYTGYLHALDYARTRPQGRPLTDRDPVAPQVPIIEHADVRRMLLAQKSYVEGALALTLYCGRLVDEQRTAPEDEARKRAGLLLDILTPIAKSWPSQWCLEANSLAIQVHGGYGYTREYDVEQFYRDNRLNPIHEGTHGIHGLDLLGRKAVIDGGAALRLLLGEAAATADRAGAGGGVLAEYGAALNAATRRVAEVTARLWSTGDPGTALANASVYLEAVGHVVVAWMWLEQLLAADGATGDFYEGKRAAGQYFFRHELPSVHPKFDLLESLDRTAADMDPAQF
>NZ_CP045178.1|WP_077968242.1|6183258_6183792_+|GNAT-family-N-acetyltransferase
MTQQRTVHTADLTAGELSRIRVLLEAAFKGDFDDSDWEHGLGGQHVLIDHGGGLVAHGSVVQRRVLHHGRSLRAGYIEAVAVRADARRRGLGSRVMRELERLVDGAYDLGALAASDEGAPLYAARDWWRWPGTLGTLGPSGPVPLPEEEGAVWVRSAPHALDSSDGLLFDWRDGDVL
>NZ_CP045178.1|WP_077968240.1|6181455_6183087_+|L-glutamate-gamma-semialdehyde-dehydrogenase
MDAVTQVPAPVNEPVHGYAPGSPERARLEAKLKELADNPIELPMTIGGVKRLGGGEEFKVVQPHNHKSVIGTGRGATTQDAQDAVDAALAAAPAWRAMSFDDRAAIILRAADLLSGPWRETVAASAMLGQGKTAQQAEIDVPCELVDFWRFNVHYARQILAEQPPANSRGVWNRMDHRPLEGFVYAITPFNFSAIALNLPTAPALMGNVVVWKPSPTQTHAAVLLMKVLEEAGLPKGVINLVTGDGIAVSEVALAHRDLAGIHFTGSTKTFQHLWKTVGANIENYRTYPRLVGETGGKDFVVAHPSADRGVLKTALTRGSFEYQGQKCSATSRAYIPASIWNDGFKEEFAAEVDGIAMGDVTDLSNFIGAVIDDRAFAKNKAAIDRAKSDATCTIVAGGSYDDSVGYFVRPTVIECTDPENEVFTTEYFGPVLSVYVYEDDNYDAMLDQMESVSDYALTGSVIAGDRQAAVHTMEKLRYAAGNFYINDKSTGAVVGQQPFGGGRASGTNDKAGAPQNLQRWTLTRAIKDSLLSPTEYGYPHMG
>NZ_CP045178.1|WP_077968239.1|6180331_6181258_+|proline-dehydrogenase
MLGPVILAASRSDRLRRIVSAAPVTKQVVTRFIAGEGVATTVPAVRRMAEHGLDVTLDVLGEDITDPTEALRARDAYLELIEALGPLGLGPRAEMSVKLSSFGQALPGGHDLALANVTPVVEAATAIGTTVTLDMEDHTTVDSTLAIGRTLREKFPQTGAVVQSYLFRTEDDCRALAEEGARVRLVKGAYKEPASVAYQDKAEVDKAYVRCLRILMDGSGYPMVGSHDPRLITIAQELARHAGRKLEEYEFQMLYGIRDTEQVRLAAEGHRMRVYTAYGTDWYGYFMRRLAERPANLAFFLRSMVTRG
>NZ_CP045178.1|WP_077968237.1|6178992_6180132_-|PucR-family-transcriptional-regulator
MKGDYQELIDEISALLGAPATLEDREFGLIAFGAHDSGGSVDEAALDPVRTRSILTRTSSNAVRAWFEGFGITHATGPLRIPAAPDAGVLRGRICLPVRRRGVVHGYVWLLDGEPGPTDAQLAAAMQVADRIGLLMADEATAEDDVTREFRRVILSDSGWERDTALTALRTALGASADELYTVVCVTPWASDGPPSPRRVPGTAAGCVLATAGGGRMLALLVRVRTAAGAPASVLTAVGSLAAGSAAGAGAPRRGPAEVPALWQEAAAAARAAAAEPQLGPVAQWSAIGPYRLLTALPPGAAHDPVLRDLLAPAHAELARTVEVFLDHAGQAGRTAAALGIHRQTLYYRLSRVEQLTGLDLGDGEHRLLLHMAVKASRL
>NZ_CP045178.1|WP_077968255.1|6195004_6196660_+|citramalate-synthase
MTSQATDGTAPTAADAAGSADAAVEHGFHVFDTTLRDGAQREGINLTVADKLTIARHLDEFGVGFIEGGWPGANPRDTEFFSRARQEIDFRNAQLVAFGATRRANAKAADDPQVKALLDSGAQVITLVAKSHDRHVELALRTTLEENLEMVSDTVSHLRAQGRRVFVDCEHFFDGYRANPEYAKAVVRAAAEAGADVVVLCDTNGGMLPAQIQAVVSTVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNANLFPVVGALELKYGMEVLPEGSLREMTRISHAIAEVVNLAPSTHQPYVGVSAFAHKAGLHASAIKIDPDLYQHIDPDLVGNRLRMLVSDMAGRASIELKGKELGIDLGDDRALVGRVVERVKERELQGYSYEAADASFELLLRQEVEGKARSYFRTESWRAIVEDRPDGTHANEATVKLWAKGERIVATAEGNGPVNALDRALRVALERIYPQLDDLELTDYKVRILEGRHGTDSTTRVLISTSDGTGEWSTVGVAENVIAASWQALVDAYTYGLLRAGVAPAE
>NZ_CP045178.1|WP_077968257.1|6197227_6198598_+|hypothetical-protein
MAGPSRTARRLITLLSGILLALGAVLATAPGAQAASDLSDVADGLRDGPVYVDPAMRDQFPKSDADALAKKIKDADRAVFVAVLPVDQPTKNLFSDLRSRTGVTGVYGIRLGDAFDARADSRAMSTQSLRNILGSVKGEPLTTQLNDFTDQALRTANGSAPESWGGSDDGGVPVGALVGVGAVVVLGGAGLYAGVRRSRKRRAEEQRAALERLRVVVDEDITAFGEELDRLDFHPAEDGADDAMRADYERALDSYEQAKSIMASAQRPEDVRGVTEALEDGRFSLATLAARRKGGELPERRVPCFFDPRHGPSVADVTWSPATGAEREVPVCAADKARLEDGQDPETRTVDTAYGRRPYWDAGPAYGPWAGGYFGGGMLPGLLVGTMLGSAMASPAYASDYGSGYGDFGGQGGFDGGDVSGSDFNPGDFGDFGGGGGGFGGDNNNFGGGGDFGGGF
>NZ_CP045178.1|WP_077968259.1|6198849_6199464_-|YceI-family-protein
MGLFSRKNDSGSDSGTAPATAATDLTELTGDYTIDPAHTTLGFSARHAMVTNVKGSFNELEGTLHLDGSDPAKSSASIDVQLASVDTGSPDRDGHLKSGDFFKVDEFPVMSFRSTQVEPLGGEDYRLTGELTIHGITKPLTIDLEFNGVATDPFGNERAGFEGKSELLRSDWGLTYNATLETGGVLVSDRIKLNFDISAIKNAG
>NZ_CP045178.1|WP_077968261.1|6199876_6201460_+|acyl-CoA-carboxylase-subunit-beta
MTVLDETPGEPKDARGRVAELHAIREQALRGPSDKATEAQHAKGKLTARERIELLLDPESFHEVEQLRRHRATGFGLEAKKPYTDGVITGWGTVEGRTVFVYAHDFRIFGGALGEAHATKIHKIMDKAIAAGAPLVSLNDGAGARIQEGVSALAGYGGIFQRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRDTSQMFITGPDVVRAVTGEEITQNGLGGADVHAETSGVAHFAYDDEETCLAEVRYLLSMLPQNNRENPPTVEAQDPADRSGDVLLDLVPADGNRPYDMRKVIEEIVDDGDYLEIHERWATNILCALARLDGQVVGIVANQPQSLAGVLDIEASEKAARFVQMCDAFNIPIVTLLDVPGFLPGVDQEHGGIIRHGAKLLYAYCNATVPRISLILRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRRQIAEAEDPEAMRVRMVKEYKAELMHPYYAAERGLVDDVIDPAQTRQVLIGSLAMLRSKHADLPSRKHGNPPQ
>NZ_CP045178.1|WP_077968264.1|6201519_6201759_+|acyl-CoA-carboxylase-subunit-epsilon
MSEPVPSSTTPDAVGDFLRVERGQAGPEELAAITAVLMARAAARPAEIGAGTHRGRTDRAGWRRLERTPGFRAPHSWQG
>NZ_CP045178.1|WP_152330808.1|6202034_6202616_-|ATP-binding-protein
MDFASSNGGSARSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYTPDEVREALQIGPDTPIITTDARHRADAKSGLITLVEHALMARLR
>NZ_CP045178.1|WP_152330809.1|6202596_6203259_-|DUF742-domain-containing-protein
MTTSPSGSSADWPYGQDGDRRDDSPDGYGSPSSHSHRRQDQRHPGASRQQNSRPSYGQEPYARQPYAQEPYGQQPYGGGPGNGQQHSPRIQPVQPGWPASQRGPTGGASNPLVRPYAMTGGRTRPRYQLAIEALVSTTAQPSQLQGQLPEHQRICQLCREIKSVAEISALLSIPLGVARILVADLAEAGLVAIHQPGGDDAGGQPDVTLLERVLSGLRKL
>NZ_CP045178.1|WP_152330810.1|6203351_6203765_-|roadblock/LC7-domain-containing-protein
MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGTVNQTVVEMERGFLFIMSISDGSSLAVLAHPEADIGLVGYEMALLVDRAGTVLTPDLRAELQGSLLN
>NZ_CP045178.1|WP_077974572.1|6203775_6207363_-|HAMP-domain-containing-protein
MRRSTTGSGPAARTRGNFTPPGRSGAPAQTPQDGRDTAAAAGSRMSPRNWRVPTRLNAILLIPVIVGLVMGGFQVKGSVDTWQEADAAERTARLVRTSLLYGNRLIEERDISAAPLLRGDRNDPAVVKARRATDRAADAFDRAASDMPHKEGLVRRLRAFHKVEPGLATLREHAYTSQYKGVGTEEGYVAIQHPLMEIANELGLGTGNITSYGRTVYALSLAKAAISLQRSIGTHLMVKPEPDSSSTARRRVALTSYLYLENIATEEYTSGGTERDVRALREAEKKLAADSREQAAEAAAKAKAAGRKPAPALDPEKTVEAIAAPGATKRSLASRGITPESWWASTTARFDAYRTIESALADKAVSETSDIADDARRDTFITAAAIVIALLVAFLLAGMVARQMSRAMRRLRTAAFGIAEQRLPTLVDQLSRTDPGRVDTRVRPIPITSTDEIGEVARAFDQVHREAVRLAAEQAMLRGNINAIFTNLSRRNQSLIEGQLSLISDLESHEAEPEQLENLFRLDHLATRMRRNGENLLVLAGEEPGRRWDQPVPLVDVFRAAASEVEQYERVDLENIPDAEIHGRAVTDLVHLLAELLENATSFSSPQTKVRVVATRIPDGRVLIEIHDKGIGLTAEDFADINHKLAMPPTVDVAISRRMGLFVVGRLSDRHGIRVQLRPSGEQAGTTSLVTLPEAITHGGGEEQLLGQPEFTVPSLAPEQADPPHPTPLRTTAELGFDDGPWSAGHGREDTREPDPADRSPIRGEHGAALEDRARPGGDRPLFRDEVAPAPPFDERSGGPTAPGQGYGTPRYEPHEEQPPYEGQPAYEGQSPYEGQPGTSFEAGTSEGGHARGLPGREQSYDRQGTTGHAEGPPGVHGGQENEYGHQGGEFAAELRGYAGDPSGHGPQATYGDRQDGHGGAPGGYAEHPEQDGGYGLSVPALPEAGERGGPQELPSPEAADPRHSGPTSERYGSERYGSEQYGGVGDQPHQEVGQDGDAFLDSFRPGNAPEPESVRQAPPADQERVGFDRPGPVASSVHDVTDAGLPRRGGPAAVRGGDGGQQWRQPVNSQDGGRPSLAEPERGEQPQPAAAEGEAFPANVNDERRLRAEQSRQPTAGGVTPSGLPRRVPRANLVEGTAEQSPRGGPQVSRAPEDVRGRLSKLRRGVERGRTAGSDTNGTNSRGSGPDGTYDQER
>NZ_CP045178.1|WP_152330811.1|6207698_6208280_-|ATP-binding-protein
MDFASSNGGSARSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGHQPYTPDEVREALQIGPDTPIITTDARHRADAKSGLITLVEHALMARLK

Crispr_ID: NZ_CP045178_23

• CRISPR_ID: NZ_CP045178_23
• CRISPR_location: 6333412-6333496
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_23

Consensus_repeat	Method
TGCCACCCGCGGCCGCACCGCGC	CRISPRCasFinder

spacers of NZ_CP045178_23

>23.1|6333435|39|NZ_CP045178|CRISPRCasFinder
ACCGCGCGCCGTACGGCGCGCGGCCGGCACGCCGTACGG

CRISPR arrays and Neighbor proteins around NZ_CP045178_23

CRISPR arrays

The CRISPR arrays of NZ_CP045178_23

>merge|NZ_CP045178|23|6333412-6333496|CRISPRCasFinder
TGCCACCCGCGGCCGCACCGCGCACCGCGCGCCGTACGGCGCGCGGCCGGCACGCCGTACGGTGCCACTCGCGGCCGCACCGCGC

>NZ_CP045178|23|18|6333412-6333496|CRISPRCasFinder
TGCCACCCGCGGCCGCACCGCGC	ACCGCGCGCCGTACGGCGCGCGGCCGGCACGCCGTACGG
TGCCACTCGCGGCCGCACCGCGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077969923.1|6343345_6343930_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|223532
NZ_CP045178.1|WP_077969887.1|6329547_6331221_+|PucR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|377939
NZ_CP045178.1|WP_077969902.1|6337980_6339282_+|site-2-protease-family-protein	unknown	unknown	gnl|CDD|100084
NZ_CP045178.1|WP_077969899.1|6335802_6336633_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|163539
NZ_CP045178.1|WP_077969871.1|6319518_6320451_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224097
NZ_CP045178.1|WP_077969876.1|6323474_6323957_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969900.1|6336685_6337984_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl|CDD|235472
NZ_CP045178.1|WP_077969874.1|6321323_6322739_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274522
NZ_CP045178.1|WP_077969921.1|6342192_6342963_+|DUF1684-domain-containing-protein	unknown	unknown	gnl|CDD|377941
NZ_CP045178.1|WP_077969892.1|6333648_6335619_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173850
NZ_CP045178.1|WP_077969996.1|6341201_6342044_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|379120
NZ_CP045178.1|WP_077969873.1|6320450_6321260_+|ABC-transporter-permease	unknown	unknown	gnl|CDD|224098
NZ_CP045178.1|WP_077969931.1|6346244_6347165_-|kinase	unknown	unknown	gnl|CDD|309685
NZ_CP045178.1|WP_077969885.1|6325079_6326411_-|4-aminobutyrate--2-oxoglutarate-transaminase	unknown	unknown	gnl|CDD|235685
NZ_CP045178.1|WP_077969883.1|6324029_6324926_-|phosphatase-PAP2-family-protein	unknown	unknown	gnl|CDD|239486
NZ_CP045178.1|WP_077969904.1|6339454_6340609_+|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	unknown	unknown	gnl|CDD|234737
NZ_CP045178.1|WP_077969994.1|6327125_6329402_+|ATP-binding-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969929.1|6343999_6345691_+|proline--tRNA-ligase	unknown	unknown	gnl|CDD|236405
NZ_CP045178.1|WP_077969889.1|6331774_6333220_+|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|143465
NZ_CP045178.1|WP_077969869.1|6318355_6319522_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226361

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077969923.1|6343345_6343930_+|GNAT-family-N-acetyltransferase	gnl|CDD|223532	COG0456, RimI, Acetyltransferases [General function prediction only].	7.00633e-06
NZ_CP045178.1|WP_077969887.1|6329547_6331221_+|PucR-family-transcriptional-regulator	gnl|CDD|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	1.39367e-28
NZ_CP045178.1|WP_077969899.1|6335802_6336633_+|GNAT-family-N-acetyltransferase	gnl|CDD|163539	TIGR03827, GNAT_ablB, putative beta-lysine N-acetyltransferase. Members of this protein family are GNAT family acetyltransferases, based on a seed alignment in which every member is associated with a lysine 2,3-aminomutase family protein, usually as the adjacent gene. This family includes AblB, the enzyme beta-lysine acetyltransferase that completes the two-step synthesis of the osmolyte (compatible solute) N-epsilon-acetyl-beta-lysine; all members of the family may have this function. Note that N-epsilon-acetyl-beta-lysine has been observed only in methanogenic archaea (e.g. Methanosarcina) but that this model, paired with TIGR03820, suggests a much broader distribution.	0.00402637
NZ_CP045178.1|WP_077969871.1|6319518_6320451_+|ABC-transporter-permease	gnl|CDD|224097	COG1176, PotB, ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism].	8.0696e-80
NZ_CP045178.1|WP_077969874.1|6321323_6322739_+|FAD-dependent-oxidoreductase	gnl|CDD|274522	TIGR03329, Phn_aa_oxid, putative aminophosphonate oxidoreductase. This clade of sequences are members of the pfam01266 family of FAD-dependent oxidoreductases. Characterized proteins within this family include glycerol-3-phosphate dehydrogenase (1.1.99.5), sarcosine oxidase beta subunit (1.5.3.1) and a number of deaminating amino acid oxidases (1.4.-.-). These genes have been consistently observed in a genomic context including genes for the import and catabolism of 2-aminoethylphosphonate (AEP). If the substrate of this oxidoreductase is AEP itself, then it is probably acting in the manner of a deaminating oxidase, resulting in the same product (phosphonoacetaldehyde) as the transaminase PhnW (TIGR02326), but releasing ammonia instead of coupling to pyruvate:alanine. Alternatively, it is reasonable to suppose that the various ABC cassette transporters which are also associated with these loci allow the import of phosphonates closely related to AEP which may not be substrates for PhnW.	1.11386e-66
NZ_CP045178.1|WP_077969900.1|6336685_6337984_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl|CDD|235472	PRK05447, PRK05447, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional.	0
NZ_CP045178.1|WP_077969902.1|6337980_6339282_+|site-2-protease-family-protein	gnl|CDD|100084	cd06163, S2P-M50_PDZ_RseP-like, RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog RseP is involved in the sigmaE pathway of extracytoplasmic stress responses. Also included in this group are such homologs as Bacillus subtilis YluC, Mycobacterium tuberculosis Rv2869c S2P, and Bordetella bronchiseptica HurP. Rv2869c S2P appears to have a role in the regulation of prokaryotic lipid biosynthesis and membrane composition and YluC of Bacillus has a role in transducing membrane stress. This group includes bacterial and eukaryotic S2P/M50s homologs with either one or two PDZ domains present. PDZ domains are believed to have a regulatory role. The RseP PDZ domain is required for the inhibitory reaction that prevents cleavage of its substrate, RseA.	2.17737e-46
NZ_CP045178.1|WP_077969921.1|6342192_6342963_+|DUF1684-domain-containing-protein	gnl|CDD|377941	pfam07920, DUF1684, Protein of unknown function (DUF1684). The sequences featured in this family are found in hypothetical archaeal and bacterial proteins of unknown function. The region in question is approximately 200 amino acids long.	8.66529e-44
NZ_CP045178.1|WP_077969892.1|6333648_6335619_+|acyl-CoA-dehydrogenase	gnl|CDD|173850	cd01161, VLCAD, Very long chain acyl-CoA dehydrogenase. VLCAD is an acyl-CoA dehydrogenase (ACAD), which is found in the mitochondria of eukaryotes and in some bacteria. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. VLCAD acts as a homodimer.	2.72769e-90
NZ_CP045178.1|WP_077969996.1|6341201_6342044_+|GNAT-family-N-acetyltransferase	gnl|CDD|379120	pfam13312, DUF4081, Domain of unknown function (DUF4081). This domain is often found N-terminal to the GNAT acetyltransferase domain, pfam00583 and FR47, pfam08445.	7.85142e-50
NZ_CP045178.1|WP_077969873.1|6320450_6321260_+|ABC-transporter-permease	gnl|CDD|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	4.76718e-68
NZ_CP045178.1|WP_077969931.1|6346244_6347165_-|kinase	gnl|CDD|309685	pfam04655, APH_6_hur, Aminoglycoside/hydroxyurea antibiotic resistance kinase. The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.	2.79299e-48
NZ_CP045178.1|WP_077969885.1|6325079_6326411_-|4-aminobutyrate--2-oxoglutarate-transaminase	gnl|CDD|235685	PRK06058, PRK06058, 4-aminobutyrate--2-oxoglutarate transaminase.	0
NZ_CP045178.1|WP_077969883.1|6324029_6324926_-|phosphatase-PAP2-family-protein	gnl|CDD|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.02296e-28
NZ_CP045178.1|WP_077969904.1|6339454_6340609_+|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase	gnl|CDD|234737	PRK00366, ispG, flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.	0
NZ_CP045178.1|WP_077969929.1|6343999_6345691_+|proline--tRNA-ligase	gnl|CDD|236405	PRK09194, PRK09194, prolyl-tRNA synthetase; Provisional.	0
NZ_CP045178.1|WP_077969889.1|6331774_6333220_+|aldehyde-dehydrogenase-family-protein	gnl|CDD|143465	cd07147, ALDH_F21_RNP123, Aldehyde dehydrogenase family 21A1-like. Aldehyde dehydrogenase ALDH21A1 (gene name RNP123) was first described in the moss Tortula ruralis and is believed to play an important role in the detoxification of aldehydes generated in response to desiccation- and salinity-stress, and ALDH21A1 expression represents a unique stress tolerance mechanism. So far, of plants, only the bryophyte sequence has been observed, but similar protein sequences from bacteria and archaea are also present in this CD.	0
NZ_CP045178.1|WP_077969869.1|6318355_6319522_+|ABC-transporter-ATP-binding-protein	gnl|CDD|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	8.9603e-155

Protein sequences

>NZ_CP045178.1|WP_077969889.1|6331774_6333220_+|aldehyde-dehydrogenase-family-protein
MTSTHAFWLAGRQATGETTFDVTSPWDGRLVGKVSVPTDAQVEEAVAAAHAVRDEFAGTPAHVRAAALELVTRRLVERTEELAQLISAENGKPLKWARGEVGRAVSVFRFATEEARRFNGGEAQRLDTDGGGTGRLALTRRFPRGAVLGIAPFNFPLNLCAHKIAPAIAAGAPIILKPAPATPLSALILGELLSETDLPAGSWSVLPVSNDRMPALVQDERLPVISFTGSEKVGYSIMESVPRKHCTLELGGNGAAVILADYASDKDLDWAAARIATFSNYQGGQSCISVQRVIADASVYDRLVPRIVKAVETQVTGDPSDIATDVGPLVSEDAAKRVESWVDEAVKAGASLLAGGKRDGASYAPTVLADLPADTTLAREEVFGPVLSVRKVSGETEAFAAVNDSKYGLQAGVFTHDVQTAFRAHRALEVGGVIVGDVPSYRADQMPYGGAKQSGVGREGVRFAMEDYTYERVMVFTGLDL
>NZ_CP045178.1|WP_077969887.1|6329547_6331221_+|PucR-family-transcriptional-regulator
MPPTLATLVHHSALKLTVRAGEERLNTPVRWAHASELADPLPYMEGGELLLITALKLDAEDPEEMRSYVKRLVGAGVAGIGFAVGVNYEDIPAALVQAASAECLPLLEVPRKTPFLAISKAVSAAIAADQYRAVTAGFAAQRELTKQALGEGPEGLLRALAGQLDGWAALYDASGAVVATAPEWSARRAARLTPDVQRLRDRPAPASAVVAGAEDRVELHSLGTGRRPRAALAVGTASTLGTAERYAVHSAIALLTLTTERSRAFQAAEQRIGAAVLGLLLAGEPDHARAVAGDLYGGLLDAPFRLIIADTAATSAARSRAQARTGTGRTIPGSGTVTLAGEGIGGTAAAYDALSDAVESAAARAGEAVLVVPDGERLVLLATDRGAAAEACTRHAELLDMGRPPNGAHTNEDIVLGLSAPAGPVAATTAYRQAEQAISVARRRGRTLVEHEDVAAGSVLPLLADDAVRAFADGLLRALHDHDATGRGDLVASLRAWLSRHGQWDAAAADLGVHRHTLRYRMRRVEEILGRSLDDPDVRMELWLALKTTTTVGTTTE
>NZ_CP045178.1|WP_077969994.1|6327125_6329402_+|ATP-binding-protein
MPPHTPGQQPVSTWDAPERGNGAAPVPQEPSFPPYAGAAPGSEPFHPGGPPVYGTPTYSGADSPIGVPALPGQHSRLPARPDRAPGVLESATPQDGSAFLTWLRAPRPAAEPGVWRFGHRPKPQEVAQPVPARQLLSGAVIAFLVGWLLWSLLWNGYLGGWWLLPLYAAIPDSWAEPHSVASVVVVYAYYAIIALAIMTAVGRLGRWGEVWRRYGTPAWRRAAPPPPPRHAPEEDPARWPHLRAAGAEAAADRLTAEAGAGLMRDVDHARISRAWHSVQAGRHAMGAFTESVLRDGAAACLHPSGNRDLPSRAARHDLVTAQVRLGTSADDQRNPYAYRGTGLALGPDLLGTSLLAVGPAGSGKTGRVVWPLAESLCLQALAGRAAVVVVGAAGSGLGPADDYDVIVRVGNPDSAYDIDLYGGATDPDEAAAVLAEALAGDLTQPHPGADSRRSTTVLAQLLGPFRAVHGRFPSVPELRELLDGAPAPLAALRRALEDEGQLGMVRELDARARQSGTSTDPGTVLADRVALLDRPAFSGFFDTSGQSRPFSLRSLDHPVRVRIDLPERGHADASRILARLVLAQFSMSVAARVDRSLFACLVVDDATGTITPESVRGIQRLRSAHAGVVLTLRTLDDVPRPLRGPLLGAAGCRMALSGVTPWDGQDFAEVWGKEWTETRDITDRQIVADEPLAKATHFVRKVITGKAPTAQSVTVRKVERERWSASELAHAVPPGHAVLSLTTVRGEHAPPLLVDLTG
>NZ_CP045178.1|WP_077969885.1|6325079_6326411_-|4-aminobutyrate--2-oxoglutarate-transaminase
MSAIPQERRVVTAIPGPKSQELQTRRIAAVAAGVGSTMPVFAARAGGGIVEDVDGNRLIDFGSGIAVTTVGSSAEAVVRRASAQLADFTHTCFMVTPYEGYVAVAEQLAELTPGDHAKKSALFNSGAEAVENAVKIARAHTKRQAVIVFDHGYHGRTNLTMALTSKNMPYKDGFGPFAPEVYRVPVAYGYRWPTGPENCGPEAAAQAIDQISKQVGADNVAAIIIEPLLGEGGFIEPAKGFLPALRQFATDHGIVFVADEIQSGFCRTGQWFACEDEGVVPDLITTAKGIAGGLPLSAVTGRAEIMDAAHSGGLGGTYGGNPVACAAALGAIETMKEQDLNGKAKRIEAVMKSRLTAMQEKFDIIGDVRGRGAMIAVELVKAGTKDPNPEATAALAKACHGEGLLVLTCGTYGNVLRFLPPLVIGEELLNEGLGIIEEALAHV
>NZ_CP045178.1|WP_077969883.1|6324029_6324926_-|phosphatase-PAP2-family-protein
MRETPRPQGTADDAWTKPPQFRLGCAFAHTAGASGSGNPHRSDGRPPHTPRGARYPGQDGCPGTSPPVPGQPYVVIGICVLLFALCTWLALAGGPLLRADERFGGVVFRGPMPRGVAEFLSDLGNTTIALPVLAVVIAYSGWQSHRRRTARWWLPGLSAAVSMAAVPALVVPFKEFVARPAPPTMEGVGYYPSGHTATASVAYGACVLLILPLLRSPVTRRVLRISWAVLSVAVGIGLVRCAYHWPLDVLASWCLAVILLELMALTAQRENTGPGPRGQRRPSPRRPREGRGDSRTAD
>NZ_CP045178.1|WP_077969876.1|6323474_6323957_+|hypothetical-protein
MTGAGTDVRTAVEWLVSVASDPEGCRFAWERDPSGVALLPAGRGWDVLIVPGPLGRSTLDVLERLTPRPGPVLARSEGALHGFFVPAGTNGCWVAKGVRGAGVGSWIAVPYPGCGARHATRHLQWAVAPDGSGVLTDPELLELAMHDAVARTARDPSRDG
>NZ_CP045178.1|WP_077969874.1|6321323_6322739_+|FAD-dependent-oxidoreductase
MAPSAMTRPTAALVDVQPLAFWLDDPDRPAPEAPLVGDAQCDLLVVGGGYSGLWTALLAKERDPSRDVVLVEGREAGWAASGRNGGFCAASLTHGLPNGLDRWPSEIAKLEQLGGRNLDAIQAAVARYGIDCDFQRTGEIDIATQPHQVAELRAARDTAARHGFTGLELLDQDAVRAEVDSPTFLAGLHDPCGVALLNPARLAWGLKRACLALGVRVHEHTAALELARYGSGMAVRTPHGRVFARRVALGTNVFRSLVRRTRPYTVPVYDYALMTEPLSGTRLASIGWKNRQGLGDNANQFHYFRLSADNRVLWGGYDAIYPYGGKVRASYDHRPETYERLAARFFQCFPQLEGVRFTHAWGGAIDTCSRFSAFFGAAHGGRVAYAAGYTGLGVGATRFGAEVMLDLLAGERTERTELTMVRTKPVPFPPEPLAWGGIELTKRSMARADRNGGRRNLWLRTMDRLGLGFDS
>NZ_CP045178.1|WP_077969873.1|6320450_6321260_+|ABC-transporter-permease
MNPRTLLRAVRRNFVLLAGLLTLVYLILPNVVVMVFSFNKPNGRFNYEWQRFSTDAWADPCGVADMCGSLSLSLQIAGWATLGATLLGTMIAFALVRYRFRARPAVNSLIFLPMAMPEVVMGASLLTLFLNVGAPLGFWTILIAHIMFCLSFVVTAVKARVMSMDPRLEQAAQDLYAGPFQTFVRVTLPIAAPGIAAGALLAFALSFDDFIITNFNAGSTVTFPMYVWGSAQRGTPVQINVIGTAMFVIAVLLVVSGMLIGNRRGRRSA
>NZ_CP045178.1|WP_077969871.1|6319518_6320451_+|ABC-transporter-permease
MTVTEVPPAPPAAEADPPADAPRRRGRLVPYWLLLPGILWLVFFFALPMIYQASTSVQTGSLEDGFKVSWHFATYWDAFSDYWPQFLRSIGYAAVATLLCLLLGYPLAYLIAFRAGRWRNAVLILVIAPFFTSFLIRTLAWKTILADSGPVVGALNTLHILDVTSTLGITSGDRVLATPLAVVCGLTYNFLPFMILPLYTSLERIDGRLLEAAGDLYARPATTFRRVTFPLSMPGVVSGTLLTFIPATGDYVNADLLGSTDTRMIGNVIQTQFLRVLDYPTAAALSFILMAAILVAVTVYLRKAGTEDLV
>NZ_CP045178.1|WP_077969869.1|6318355_6319522_+|ABC-transporter-ATP-binding-protein
MTIATPSNTSLTSDHAGDVRLSGITRNYGDFTAVHPLDLTVRHGAFFALLGPSGCGKTTTLRMIAGLETPTSGTVHLGDHDVTVLPPHKRPVNTVFQSYALFPHLDIYENVAFGLRRRGIKSVQKQVGEMLDLVQLGDFARRKPHQLSGGQQQRVAVARALVNHPKVLLLDEPLGALDLKLRRQMQLELKRIQTEVGITFVHVTHDQEEAMTMADTVAVMNAGHIEQLGSPADLYENPRTTFVANFLGTSNLIEARIDSRDGDVLVVVSGAATLRLPIDRCATSTARGGEVHVGVRPEKITLTHPDDAASIPEGRNRLTGRITATSFIGVSTQYLIDCPACPEFEVYAQNIERDARLVPGAEIVMHWNPVYTIGLSADQDIEAGEEEV
>NZ_CP045178.1|WP_077969892.1|6333648_6335619_+|acyl-CoA-dehydrogenase
MTAPPTHTSEAPEPGTSRSGVTEREARQVAEAAREQDWHKPSFAKELFLGRFRLDLIHPHPVPTDEATRRGEEFLARLRAFCETRIDGALIEREACIPDEVIAGLKELGALGMKIDTQYGGLGLTQVYYNRALALVGSASPAIGALLSAHQSIGVPQPLKQFGTQEQRDVFLPRCARTDISAFLLTEPDVGSDPARLATSAVRDGDEYVLDGVKLWTTNGVVADLLVVMARVPRSGEEKGGITAFVVEATSEGITVENRNVFMGLRGLENGVTRFHQVRVPAANRIGPEGAGLKIALTTLNTGRLSLPAMCVGSGKWCLKIAREWSAAREQWGRPVALHEAVGAKIAFIAATTFALEAVVDLSSQMADENRNDIRIEAALAKLYGSEMGWLIADELVQIRGGRGFETADSLAARGERAVPAEQLLRDMRINRIFEGSTEIMHLLIAREAVDAHLSVAGDLIDPEKSLGDKAKAGARAGGFYARWLPKLVTGPGQLPGSYGEFHPAGHADLSGHLRYVERTARKLARSTFYAMSRWQGRMETKQGFLGRIVDIGAELFAMSAACVRAELLRTSDDHGREAYQLADAFCRQARIRADELFARLWTNTDDVDHKVVKGVLAGTYAWLEEGVIDASGEGPWIADATPGPSQRENVHRTIG
>NZ_CP045178.1|WP_077969899.1|6335802_6336633_+|GNAT-family-N-acetyltransferase
MSSTPEKQDVTSEDLLAAYDAQLRGVTESLDTGVVAELDGPVTRISGRRQGFVSGPRDLGVTGSALDTLIARQRDHFAARGESVEWKTRAHDLPVDIPERLRAAGFVPEERETVLVGRSEKLAGEPLLPAGVTLRRVSSRYELDRIDALGAAVWGEGHPALAEDLQRQLGAAPDDLIVLVAEAAGELVCAARLELTPGLDFAGLWGGNTLEAWRGKGLYRATVAARAKIAAERGVPYLQVDASDDSAPILRRLGFVEITTTTPYVWSPDAPANVAE
>NZ_CP045178.1|WP_077969900.1|6336685_6337984_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MTDSPAPLADPHLRYDATEGRRDIVVLGSTGSIGTQAIDLVLRHPDRFRVTALSAAGGRVELLAEQAHRLRPNLLAVAREEVVPRLREALKAQYGSEPLPELVAGPDAATQLAASACHTVLNGITGSIGLAPTLAALKAGRTLALANKESLIVGGPLVKALAAPGQIIPVDSEHAALFQALAAGTRADVRKLVVTASGGPFRGRTKSDLAQVTPKDALAHPTWAMGPVITINSATLVNKGLEVIEAHLLYDIAFEQIEVVVHPQSYVHSMVEFIDGSTLVQATPPDMRGPIAVGLGWPERVPDAAPAFDWTKASSWDFYPLDTEAFPSVELARHVGQLAGTAPAVFNAANEECVDAFLKGRLPFNGIMETVTEVVEERFGAVAPGMAEGGARNGGVSRSGTSLTLTDVLDAETWARDRARELAAKVTAEARA
>NZ_CP045178.1|WP_077969902.1|6337980_6339282_+|site-2-protease-family-protein
MTILMTILGIVVFAIGLLVSIAWHELGHLSTAKLFGIRVPQYMVGFGPTVFSRKKGDTEYGVKAIPLGGYIRMIGMFPPGPDGRIEARSTSPWRGMIEDARSAAFEELEPGDETRLFYTRKPWKRVIVMFAGPFMNLILAVAIFLGVMMSFGMNTQTTTVSKVSDCVIAQSENRTTCEKGDKAAPAKAAGLEPGDKILAYNGVQVDQYDVLQSKIRDSGGTATILVERDGVRKTLHADVIRNQVSKTDGNGGYEEGKYVTAGFLGFTPASGIVRQSFGESVDQMGSMMENGVESMIALPSKIPDLWNAAFDGGERKQDSPMGVVGAARVGGDVFNLDIPPENQIAMMLFLVAGFNLSLFLFNMLPLLPLDGGHIAGALWEALRRHVARVFKRPDPGPFDVAKLMPVAYVVAGVFICFTLLVLVADVVNPVKIS
>NZ_CP045178.1|WP_077969904.1|6339454_6340609_+|flavodoxin-dependent-(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate-synthase
MTAISLGMPSVPTQLAERRKSRQIQVGSVAVGGDAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALAVIARKSQIPVIADIHFQPKYVFAAIDAGCAAVRVNPGNIKQFDDKVKEIALAAQAAGTPIRIGVNAGSLDRRLLEKYGKATPEALVESALWEASLFEEHGFRDIKISVKHNDPVVMVNAYRLLAARSDYPLHLGVTEAGPAFQGTIKSAVAFGALLAEGIGDTIRVSLSAPPVEEVKVGLQILESLNLKPRRLEIVSCPSCGRAQVDVYKLADEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKIAEQMEKDGIPSGEPEVSIS
>NZ_CP045178.1|WP_077969996.1|6341201_6342044_+|GNAT-family-N-acetyltransferase
MTQTTTRVLEPSDLDAALEVLGRDPVANAFVTARVQVAGLDPWRLGGEMWGWYADGILTSLCYAGANLVPICAGPEAVRAFADRARRAGRRCSSIVGPSEPTARLWRLLEPSWGPAREVRAHQPLMVTDRPAEHVTPDPGVRRVRKNEVDILMPACVAMFTEEVGVSPMAGDGGLLYQARVAELIGSGRSFARIEDGKVVFKAEIGAATSKACQIQGVWVDPAYRGQGIAAPGMAAVLRYALEDVAPVVSLYVNDFNAPARATYRRVGFEETGSFMSVLF
>NZ_CP045178.1|WP_077969921.1|6342192_6342963_+|DUF1684-domain-containing-protein
MHPADLSECTVSEPRPTPPQLPEIAEHQWQTWRDDRQRDLASPFGNLALVETRWLPDGERPDPGAVRPQLADGVRVTTVQRTDPATGVVEYALRRWDANSPAIQNFQYVETFPYREDWVLEADYAPVQGARRVPFEHIRDNGGTRDLAVPGDITLNIGGEPYTLSAFDDDGTLLLVFGDPTNGGVTYGAGRFLFVHRTEGEAGAQKVVLDFNRAFVPPCGFSDQYNCPMPPRQNRFHLPVEAGEKLPVFRDGFQEH
>NZ_CP045178.1|WP_077969923.1|6343345_6343930_+|GNAT-family-N-acetyltransferase
MLRFPGSEPRTPDDIVVGPLDLAARVDEALAVQAHAFGLSDEEIEVRRHIVLRHIAVPGARALGATTPENRLVGFVYGMPNDRVHWWSTVVQPYLRREHNDGWLDDSFVITELHVRPGYQNRGVGRGLITTITDTAREPQSILSAIDTDSPARGLYRSLGYTDLARKVLFPSAPMPYAVMGAPLPLRGPRQVEA
>NZ_CP045178.1|WP_077969929.1|6343999_6345691_+|proline--tRNA-ligase
MAQVQRMSRLMVKTLRDDPADAETLSHKLLVRAGYVRRTSAGIWSWLPLGKKVFDNVSRVVREEMDAIGGQEVLLPALLPKEPYEASGRWEEYGDLLFRLKDRKGGDYLLGPTHEEIFTQVVKDQCTSYKDLPVMLYQIQTKYRDEARPRSGVLRGREFQMKDSYSFDTTDEGLAESYALHRAAYQKIFARLGLDHRIVSAVSGAMGGSASEEFLAPAAAGEDTFADCPNCGYAANTEAVTFAVVAADGSAHGAVEELDTPDTPTIETLADHLGVPASATLKNLLVKVDGEIVAVGVPGDREVDLGKLGEHLAPAEVELVTAEDFEGRPELVRGYVGPQGLKLRYIADPRVAPGTAWVTGANKQDTHARNVVAGRDFEVDDYLDVVVVEDGDPCPNCGDRLKLDRAIEIGHIFQLGRKYADTFQLDVLGQNGKPVRVTMGSYGIGVSRAVAALAEQTADDQGLCWPAEVAPADVHVVAAGKALQTELAVEVSEKLGAAGVRVLVDDRQGVSPGVKFTDAELIGVPKILVAGRRSSEGVLELKDRRTGEREEMTVEEAIARLTV
>NZ_CP045178.1|WP_077969931.1|6346244_6347165_-|kinase
MAFETPQRLVRALSDTVRPDGGDGAWLDTLPELLDTATSRLGLTVERVQVPGGRSSLVALVRGQDGATATLKLAPPTAAPELEAAALAHWAGWGVCRLLDGSGGFSAPYGALTLERLHSEISLSSLPQNKALLEAADTVRKLWVEPPAPESVLFETVDTRTARQAQAMLKTADALVRPLVDGALALRDELVSGEPERFLLHGAFRQTKVLAGDRAPWLAVGPDPLVGERAYDLARLARDRLEDLVAANSGAMSARRRLNRLADSLEIDRDRLRGWTLFRATAAGVKAMATGHRREGELLLEFAGWL

Crispr_ID: NZ_CP045178_24

• CRISPR_ID: NZ_CP045178_24
• CRISPR_location: 6374445-6374588
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NZ_CP045178_24

Consensus_repeat	Method
CCTCGCGCGCCGTACGGCGCGCCA	CRISPRCasFinder

spacers of NZ_CP045178_24

>24.1|6374469|43|NZ_CP045178|CRISPRCasFinder
CCACTTGTCCCGTCACGCGTCGTACGGCGCGCCAGCACTGTCT
>24.2|6374536|29|NZ_CP045178|CRISPRCasFinder
GCGCCCCGCCCGGAGGAGGCCGTCACCCC

CRISPR arrays and Neighbor proteins around NZ_CP045178_24

CRISPR arrays

The CRISPR arrays of NZ_CP045178_24

>merge|NZ_CP045178|24|6374445-6374588|CRISPRCasFinder
TCACCCGCGACCTACGGGGCGCCTCCACTTGTCCCGTCACGCGTCGTACGGCGCGCCAGCACTGTCTCCTCGCGCGCCGTACGGCGCGCCAGCGCCCCGCCCGGAGGAGGCCGTCACCCCACCTCCGCGCCGTACGGCGCGCCA

>NZ_CP045178|24|19|6374445-6374588|CRISPRCasFinder
TCACCCGCGACCTACGGGGCGCCT	CCACTTGTCCCGTCACGCGTCGTACGGCGCGCCAGCACTGTCT
CCTCGCGCGCCGTACGGCGCGCCA	GCGCCCCGCCCGGAGGAGGCCGTCACCCC
ACCTCCGCGCCGTACGGCGCGCCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077969948.1|6359596_6360304_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224715
NZ_CP045178.1|WP_107502920.1|6368265_6372906_-|AAA-family-ATPase	unknown	unknown	gnl|CDD|223531
NZ_CP045178.1|WP_077969952.1|6362368_6363571_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223521
NZ_CP045178.1|WP_077969969.1|6378443_6379823_+|insulinase-family-protein	unknown	unknown	gnl|CDD|223685
NZ_CP045178.1|WP_077969967.1|6375483_6375771_+|30S-ribosomal-protein-S15	unknown	unknown	gnl|CDD|180170
NZ_CP045178.1|WP_077969981.1|6382720_6383635_+|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl|CDD|235107
NZ_CP045178.1|WP_077969954.1|6363567_6364509_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224094
NZ_CP045178.1|WP_077969974.1|6380662_6381118_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077970001.1|6376227_6378447_+|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl|CDD|131743
NZ_CP045178.1|WP_152330814.1|6374771_6374984_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969947.1|6358637_6359501_-|hypothetical-protein	unknown	unknown	gnl|CDD|180318
NZ_CP045178.1|WP_077969959.1|6366185_6368069_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173853
NZ_CP045178.1|WP_077969976.1|6381206_6381764_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969971.1|6379897_6380650_+|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl|CDD|234595
NZ_CP045178.1|WP_077969956.1|6364517_6365591_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|223674
NZ_CP045178.1|WP_077969951.1|6361331_6362372_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223521
NZ_CP045178.1|WP_077969949.1|6360464_6361004_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl|CDD|176643
NZ_CP045178.1|WP_077969983.1|6383780_6385466_+|ribonuclease-J	unknown	unknown	gnl|CDD|223668
NZ_CP045178.1|WP_077969965.1|6373779_6374058_-|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
NZ_CP045178.1|WP_077969978.1|6381887_6382127_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077969948.1|6359596_6360304_-|GntR-family-transcriptional-regulator	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	8.73657e-41
NZ_CP045178.1|WP_107502920.1|6368265_6372906_-|AAA-family-ATPase	gnl|CDD|223531	COG0455, flhG, Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility].	2.6815e-47
NZ_CP045178.1|WP_077969952.1|6362368_6363571_-|ABC-transporter-ATP-binding-protein	gnl|CDD|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.01608e-147
NZ_CP045178.1|WP_077969969.1|6378443_6379823_+|insulinase-family-protein	gnl|CDD|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	2.55166e-121
NZ_CP045178.1|WP_077969967.1|6375483_6375771_+|30S-ribosomal-protein-S15	gnl|CDD|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	3.44626e-51
NZ_CP045178.1|WP_077969981.1|6382720_6383635_+|4-hydroxy-tetrahydrodipicolinate-synthase	gnl|CDD|235107	PRK03170, PRK03170, dihydrodipicolinate synthase; Provisional.	2.53773e-156
NZ_CP045178.1|WP_077969954.1|6363567_6364509_-|ABC-transporter-permease	gnl|CDD|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.16859e-87
NZ_CP045178.1|WP_077970001.1|6376227_6378447_+|polyribonucleotide-nucleotidyltransferase	gnl|CDD|131743	TIGR02696, polyribonucleotide_nucleotidyltransferase, guanosine pentaphosphate synthetase I/polynucleotide phosphorylase. Sohlberg, et al. present characterization of two proteins from Streptomyces coelicolor. The protein in this family was shown to have poly(A) polymerase activity and may be responsible for polyadenylating RNA in this species. Reference 2 showed that a nearly identical plasmid-encoded protein from Streptomyces antibioticus is a bifunctional enzyme that acts also as a guanosine pentaphosphate synthetase.	0
NZ_CP045178.1|WP_077969983.1|6383780_6385466_+|ribonuclease-J	gnl|CDD|223668	COG0595, COG0595, mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair].	0
NZ_CP045178.1|WP_077969947.1|6358637_6359501_-|hypothetical-protein	gnl|CDD|180318	PRK05943, PRK05943, 50S ribosomal protein L25; Reviewed.	0.00191236
NZ_CP045178.1|WP_077969959.1|6366185_6368069_-|ABC-transporter-substrate-binding-protein	gnl|CDD|173853	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel/dipeptide/oligopeptide transport systems, which function in the import of nickel and peptides, and other closely related proteins. The oligopeptide-binding protein OppA is a periplasmic component of an ATP-binding cassette (ABC) transport system OppABCDEF consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Similar to the ABC-type dipeptide and oligopeptide import systems, nickel transporter is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, which is the initial nickel receptor that controls the chemotactic response away from nickel. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand binding domains of ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	1.17048e-105
NZ_CP045178.1|WP_077969971.1|6379897_6380650_+|4-hydroxy-tetrahydrodipicolinate-reductase	gnl|CDD|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	2.37507e-100
NZ_CP045178.1|WP_077969956.1|6364517_6365591_-|ABC-transporter-permease	gnl|CDD|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	7.16923e-112
NZ_CP045178.1|WP_077969951.1|6361331_6362372_-|ABC-transporter-ATP-binding-protein	gnl|CDD|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	7.35091e-118
NZ_CP045178.1|WP_077969949.1|6360464_6361004_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl|CDD|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	1.98452e-53
NZ_CP045178.1|WP_077969965.1|6373779_6374058_-|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.82556e-07

Protein sequences

>NZ_CP045178.1|WP_077969965.1|6373779_6374058_-|DUF397-domain-containing-protein
MTEAQDTAAQEQELRARKEREKDELYALDITGVEWLSAPGTEEHEERVEIAYLPGGAVAMRSSIEPDTVLRYTEAEWRAFVLGARDGEFDLK
>NZ_CP045178.1|WP_107502920.1|6368265_6372906_-|AAA-family-ATPase
MNSDRDGDRGGWATPGDDQSDAESAAETTGEFTIDSAAWYTQHASDTTDQSSSTAAPSTASGKDDAGTGGTARPGDSASIEEQTDAKGERSGAGMSDVAREGAAFTDAAGSAGRSDASSAPHGAPRLPPLTPPATPFPPPYGPYGGSTDLPPPSGPPVAIPGLPVGSGFEPDWGPASVPPPPPNPSPTRAPHRADDSGTTDDDGYAASGRDNDGESGEVKAAEAGTAPGIGVPEPPLSSASPSASDGQPFDHPASGGARTPDDDHDSFTWRGSYVGRDNHGSRVDNGRSATDQDPGFADAQDNASADAPSSGGSAGRGDLESGTTMRFSSASLRRQVGKERDQSDRDEAADAARAHVEGVARSSDTDDAAGADDAADAPTARKKHETDSLTGTKDTALKGARSDTVRSGADSVDTGHPADDEPRSGERQEGHFPAESADSGIAPRVSNAAEDAADRPFAGPDTPAASATSTTGISDPAAASGANPTAEAGQSAERTEGRLEDSSRSSAADSDGATPLAAAYRAQADATSPRFRAAPRPDQGTAPHGAAQPSSPSSDAEPADAESADSVRQDDAPTNSLSDDIAASLNVTPSPSNVPGTPPIAADEARNGSSAWTTSPTPSEGLPPLPPAFRPAAPQWPVQPSSAGPQTESSADAPAADGSGRQDEPAPHGASAQSPAPLPSPTSPPAQLPWQPPPPVGETAGQQHQGPQDGVSGVPGPTFPYPPLTPEQQPQPQPQRAGYGFPPPYGAIPPVPGAAAAAPSQSRDENGSAPDGQRGYGFPAPYGAAETPSPRTGGADVPPSAGPHLAPYGAPPQAAPPQGPGYGFPPSPPAAPAGGVTPPAPGAAPQGSPHGYGFPQQPHAPRGNGYGFPGGPTGPDAAAPQVGSPVPAPTGTPLPAPYGAGMPQPPADSEQKAPEQQEAPTSAPARRQPDAQAQPPAAPGQGQQWGQPGQPNAPYGAPQPPQSPQQPTAQGGPPQQPQTGALPQPQPPVDPRSGTSWPQPVQHDQRERTHPGAPLGYTAAVELSSDRLLRNNKPKAKSSRPATGGSRFRIGGKKEEAERQRKLELIRTPVLSCYRIAVISLKGGVGKTTTTTALGSTLATERQDKILAIDANPDAGTLGRRVRRETGATIRDLVQAIPYLNSYMDIRRFTSQAPSGLEIIANDVDPAVSTTFNDEDYRRAIDVLGKQYPIILTDSGTGLLYSAMRGVLDLADQLIIISTPSVDGASSASTTLDWLSAHGYAELVRRSLTVISGVRETGKTIKVDDIVSHFETRCRGVVVVPFDEHLAAGAEVNLDMMRPKVREAYFNLSALVAEDFVRAQQEQGLWTSDGNPPPIVAPPMPGQGGTPQQQPQPGQPWPGQASPGQAGPGQAGPGQAGRPGFPQQFYPGAPPQQGGRAPYGAPGQPGQAPYGAPYPQGQPGLSPGPAPHQPLPPGGAYPSQQTGQAPQTPLSPDGTTATPSRQPHPYPPRQTPSQPLPQSGPAPYQPGPRQGWPPQTQPPAAQGEAPAYRPPDTPGQIQPGQAVPPGSLHRPPADQVEEEPPPPSQ
>NZ_CP045178.1|WP_077969959.1|6366185_6368069_-|ABC-transporter-substrate-binding-protein
MDTPVQHGRAASAATRRTLRGRFRLLLAAGTAAFALTAGLATPLNPAPSPAAAADSKSTLTVAVAQSVDSLSPFLAQRLVSTSIHRLMYEYLTNYDAKDNHAIPGFATKWQPSADKLTWTYTIRENSTWSDGKPATAEDAAWTFNKMMTDDGAATVNGTFVSNFREVTAPSPTKLVIRLKKPQATMAALDVPIVPKHVWEKVKDFSKFNNDKSFPIVGDGPFILTDYKVDSYVKLKANKTFWRGAPKFDELVFRYYKDQDAAVAALRKGEVSFVAGSPSLTPAQASSLKKTKNIKVNDGPGRRFYALATNPGARTEDGKKFGTGDPALLDEKVRHALFMAVDRKTIIDKVFQGQAVQGQGYIPPRFSTYSWKPSSNQELAYDPAKAAKLLDEAGYKKNSDGKRLGKNGKPLNFRILCHATDPNDKAVGKYLREWWGDLGVGLKVDCLDNVTDDWYAGDYDLAFDGWSVNPDPDFVLSLHTCAALPAKPKETAATDNFICDKKYDTLYNKQIAEYDPAKRAALVKQMQSRLYDTGYMNVMAYPDAVEAYRTDQIKSITTMPSAAGNIFGQDGYWSWWSAVPATSNDSDSSGGGSTVVGVIVGIVVVVVLAGGGLFFFMRRRSTAEDRE
>NZ_CP045178.1|WP_077969956.1|6364517_6365591_-|ABC-transporter-permease
MSTESTPALAGSVEPPEPAEPGSTSRGPRSRTLTAYLRYVAGKLVGAAVSLFAVLVTSFFLFRLIPGDPVKQMTGGRQVSSEQIRAMRAEFGLDLPVWEQFTQYCGKALTGDLGTSYQFHAPVIDKITEALPATLLLTGTAFLLYTAIGIWLGSRSAWRNGKFGDRFHTAFALTLYSVPSFWLGLLLIITLSVGVGPIPGMFPTGGMETGGKDGFAYVLDVGHHLALPVITLVAVEYARTLLVMRSSLLDEMGSDYLTTARAKGLRDDLVRRRHAIPNAMLPTVTLIFVNLGNTVAGAILVETVFSWPGLGGLFYQALSVPDLPLVQGLFFVFAAAVIVMNMLADLIYPLLDPRVGR
>NZ_CP045178.1|WP_077969954.1|6363567_6364509_-|ABC-transporter-permease
MTPPVGQHAESSPEGAVEGPRGLVWARRRRAVARFWQQYRTHRAGLAGLVLLVVIAVVALAAPLLVGADSQSVTGAAGGPLEDPSGSFPLGTDQFGRSLLALLVWGTRVSLSVGLLAAFLSVAIGTLVGITAGHFRGWYATVIMRVTDWFLVMPTLVLAIALATVMSRSIWTTILAIGVTTWPTTARLVRAQTLAVESRPYIERARALGGGHRHIMARHVLPNVMPLVLAQTTLVISTAILTEATLAFLGLSDPSIVSWGGLLQDAREAGAVSSGNWWYLAPPGLAIAVVALAFTLCGRAIESVLNPKLGERR
>NZ_CP045178.1|WP_077969952.1|6362368_6363571_-|ABC-transporter-ATP-binding-protein
MTEPTASVPAAVQPSPASDTREPSDPPLLEVRNLTVTYGSGSSAVPAVRGVDLTVRAGQKLGVAGESGCGKSTMALALLRLLPAGAELTGEILLDGEDIRTMKWGRLRAVRWAGASIVFQGAMHSLNAVHRIGDQVAEPIVLHGRATPGAARKRAGELLEQVGLPAARSSAYPHELSGGQRQRVMIAMALACDPRLIIADEPTTALDVMIQAQILRLIEQLVADQGVGLIMISHDLAVLADTCDRLAVMYAGRVVEEGPARRVYENAQHPYGNALSAAFPRIGDMSSRHAPRGLPGDPPDPAALPGGCTFHPRCPVALDSCSTDDQPLREAGPEHRAACVLVGRDGAVSAGSSAVSDSRLRGGPDSAPPRHTDAARDGGSRDGTGKKAEPGAPDEARSTP
>NZ_CP045178.1|WP_077969951.1|6361331_6362372_-|ABC-transporter-ATP-binding-protein
MTTTPPAPSPVEETPTAPAPLLSADDLHITFPGRRGAPGARAVDGVDLDIAPGEIVALVGESGCGKTTLARSLLGLVAPTSGRVTFDGAPLDYSGRALKRYRKRAQLVLQDPSGSLNPRHTVYDAVAEGLRIHRYPGDERAAVSQALSRAGLRPPERFFLRYPHEMSGGQRQRVVIAGALALEPELIVADEPVASLDASVRGEILALFLRLRDELGLSALVVTHDLGLAWNIADRVAVMYLGRIVESGRVEQVLTSPRHPYTQALLSVLPEAPGEPVVLAGEPPDPSRIPGGCRFHARCQVLASGEAAAAGVADDCRTKDLPVLAGGQTAQVACHWAERTAHSGRP
>NZ_CP045178.1|WP_077969949.1|6360464_6361004_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MSANDPFARLPEAASFTVTSTTVTDGAAWSPEQLSGIFGVPGGKDVSPQLSWSGAPAGTKSYAVTVYDPDAPTGSGFWHWAVADIPATVIELPEGAGDDTGSGLPEGAFQLPNDARASRFIGAAPPAGHGSHRYFTVVHALDVASIGVPADATPAALGFTMAGHILGRAVLTATAETPA
>NZ_CP045178.1|WP_077969948.1|6359596_6360304_-|GntR-family-transcriptional-regulator
MTHSTHTSTSSGKQMLSEQIYTHLRDAIMRGEYAPGDALKPQDLAKEQGVSLAVVREALVRVVGEGLADRLPNRGFAVPAFSDRRWQEVAEARRAIEPVLLRLSIERGDVDWEARVRAAHHRLARTPAYAPEEGEYYSGSWSEAHRVFHRTLLEGCGNPVLLETFDRLWTASELARRWSAHRNPDRDGAAEHRRLEETTLARDADSAAEVLACHLTQTAAGLTDRTTHHGPKKKP
>NZ_CP045178.1|WP_077969947.1|6358637_6359501_-|hypothetical-protein
MTSFEASTGRHCHNAVNPLHSSMYFAPELQDALVALGLERGTMAYLAGRAAPLGAVDAGTVTATFYNFNHEHVERYIPAAWAVTTPEAVLMARLRGADGTLRRLLGAEVLASKEVAEAAELALRATEACRREARPLYAANADLPVPGEPHLALWHAATLLREHRGDGHLAALAVAGLSGIEALVLHNATGTAPTSALFMRTRGWSAQQWDAARDGLRRRGLLDEVGDLTRSGVVLRGEAEALTDRLDAAPYDHLGPAATARLTELGDGFTKRLRAAGAFPAVHFGRG
>NZ_CP045178.1|WP_152330814.1|6374771_6374984_-|hypothetical-protein
MAGHRRATGDIRCLPADRVRRAACGVRRAACGVRRAACGVRRAACGVRRAACGVRRAACGVRRAACGVRP
>NZ_CP045178.1|WP_077969967.1|6375483_6375771_+|30S-ribosomal-protein-S15
MSLDAATKKQIMTEFATKDGDTGSPEVQVALLSRRISDLTEHLKTHKHDHHSRRGLLILVGQRRRLLQYLAKKDIARFRVLVERLGIRRGAAGAR
>NZ_CP045178.1|WP_077970001.1|6376227_6378447_+|polyribonucleotide-nucleotidyltransferase
MENETHYAEAVIDNGTFGTRTIRFETGRLAKQAAGSAVAYLDDDTMVLSATTASKKPKDQLDFFPLTVDVEERMYAAGKIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQVVETIMALNPDHLYDVVAINAASCSTQLAGLPFSGPIGGTRVALIKGQWVAFPTNTELEDAVFDMVVAGRVLEDGDVAIMMVEAEATEKTIELVKGGATAPTEEVVAAGLDAAKPFIKVLCKAQAELAAKAAKPTGEFPIFLDYEDDVLEALTAAVKTELAQALTIGPKQERESELDRVKGLAAEKLLPQFEGREKEISAAYRGLTKSLVRERVIKEKKRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLSPVTRKRYMHNYNFPPYSTGETGRVGSPKRREIGHGALAERALVPVLPTREEFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAPVAGIAMGLISQQIEGETHYVTLTDILGAEDAFGDMDFKVAGTKEFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMMEAIDTPDEMSPNAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGADITIEDDGTIYIGAADGPAAEAARATINGIANPTMPEVGERYLGTVVKTTTFGAFVSLLPGKDGLLHISQIRKLAGGKRVENVEDVLGVGQKVQVEIAEIDSRGKLSLIPVVEGEEGDDTKKDDSDK
>NZ_CP045178.1|WP_077969969.1|6378443_6379823_+|insulinase-family-protein
MTSRSSRTTARTSSEARAVARTQTLLRGRDGVGTVRRTTLPGGLRVVTETLPSVRSATFGIWAHVGSRDETPTLNGATHYLEHLLFKGTAKRSALDISAALDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSTIEPEDVEAERGVILEEIAMTEDDPGDCVHDLFAHTMLGDSPVGRPVLGTVDTVNALSRDQIARFYKRHYDPTRLVVAAAGNVDHARVVRQVRSVFEKAGALGRTDAEPTGPRTGSRAVRAAGRVEVLGRKTEQAHVILGMPGLARTDDRRWAMGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSSFADCGLFGVYAGCRPNQVHDVLKICRAELDQVAEAGLTDDEIGRAIGQLSGATVLGLEDTGALMNRIGKSELCWGEQMSVDDMLARIAAVTPDEVRALAHDILGQRPSLSVIGPLKDKQAARLHDTVA
>NZ_CP045178.1|WP_077969971.1|6379897_6380650_+|4-hydroxy-tetrahydrodipicolinate-reductase
MSKLRVAVIGAKGRIGSEAVRAVEAAEDLELVAALGRGDSPETLSDSGAQVAVELTTPDSVMDNVAYCVGHGVHAVVGTTGWTEERLARLEGELESSPGTGVLIAPNFSIGAVLTMKFAERAAKYFESVEVVELHHPRKADAPSGTATRTAQLIAAARAAAGRAPQPDATATALDGARGADVDGVPVHSVRLRGLLAHQEVLLGGEGETLTIRHDSLHHSSFMPGILLGVRRVVDTPGLTFGLEHFLDLN
>NZ_CP045178.1|WP_077969974.1|6380662_6381118_+|hypothetical-protein
MRAKITYAVTAVVLIIYFVLAGSRGVMLIQHGTALTVVFGVAVLVLPLIGLWFLWKNTQFVTRANRLAAELEAEGGLPVDELTRTPAGRIDRSSADAVFVRRKAEAEDAPDDWRCWFRLAVAYQDARDTPRARKAMQHAIALRQDKGPAEA
>NZ_CP045178.1|WP_077969976.1|6381206_6381764_-|hypothetical-protein
MPLPFLTADRAFDETADDTALPFDDRESWRRPYRPGPWRVGAAAVLLLLASFVLFAAMIIVLAGAYQGAVVCAVVAVVIIAAATRLVRSGAWVCAQGLRRVGFLTTRTFSWSQITSIRTVQQPVRLLGTPRTVQGQAVVVAVKRHDSLGPLLTDHNADFLSRPEAFERAADVLEVWAEEYGHSQA
>NZ_CP045178.1|WP_077969978.1|6381887_6382127_-|hypothetical-protein
MFRRREPVPFAFIAEAERYRSNITPPRPERPSNGQIFGRTLVGLTVVAGLAGSLLFGLPALSPGQAPLHTQQSEASDNR
>NZ_CP045178.1|WP_077969981.1|6382720_6383635_+|4-hydroxy-tetrahydrodipicolinate-synthase
MAPTSTPQTPFGRVLTAMVTPLTADGALDLDGAQRLAAHLVDAGNDGLVINGTTGESPTTGDAEKTELVRAVLDAVGDRAHIIAGVGTNDTRHSVELARSAAEAGAHGLLTVTPYYNKPPQEGLYRHFTAIADSTDLPVMLYDIPGRSGVPINTETLVRLAEHPRIVANKDAKGDLGRAAWAIARSGLAWYSGDDMLNLPLLSVGAVGFVSVVGHVVTPELRSMLDAHLSGDVQKATEIHQKLLPVFTGMFRTQGVITTKAALALQGLPGGPLRLPMIELSAEETAQLKIDLAAGGVELQTQTS
>NZ_CP045178.1|WP_077969983.1|6383780_6385466_+|ribonuclease-J
MSHPHPELGPPSKLPEGGLRVTPLGGLGEIGRNMTVFEFGGRLLIVDCGVLFPEEEQPGIDLILPDFTSIRNRLDDIEGIVLTHGHEDHIGAVPYLLREKPDIPLIGSKLTLALIEAKLQEHRIRPYTLEVAEGHHERIGPFDCEFIAVNHSIPDALAVAIRTPAGMVVHTGDFKMDQLPLDRRLTDLPAFARLGEEGIDLLLTDSTNAEVPGFVPPERDISNVLRQVFAGASKRIIVASFASHVHRIQQVLDAAHEYGRRVAFVGRSMVRNMGIARDLGYLRVPAGLVVDVKALDDLPDEEVVLVCTGSQGEPMAALSRMANRDHQIRIVQGDTVILASSLIPGNENAVYRVINGLTRWGAHVVHKGNAKVHVSGHASAGELLYFYNICKPKNLMPVHGEWRHLRANAELGALTGIPHDRIVIAEDGVVVDLIKGKAKIAGKVQAGYVYVDGLSVGDVTETSLKDRRILGDEGIISVFLVLDSTTGKITGGPHIQARGSGIEDGAFNAVKPKINEVLEKSAQDGVVEAHQLQQLIRRTLGKWVSDNYRRRPMILPVVVEV

Crispr_ID: NZ_CP045178_25

• CRISPR_ID: NZ_CP045178_25
• CRISPR_location: 6879176-6879510
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of NZ_CP045178_25

Consensus_repeat	Method
GTCGCCCCCGCGCCTGCGGGGATGTTCC	PILER-CR
GTCGCCCCCGCGCCTGCGGGGATGTTCC	CRISPRCasFinder
GTCGCCCCCGCGCCTGCGGGGATGTTCC	CRT

spacers of NZ_CP045178_25

>25.1|6879204|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT
GTTCTCCAGCCGGGCGTTGCGGATCTTGGCGCG
>25.2|6879265|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT
GCGCTGCTCGGGGCGGTACTACACCGTCCCGAG
>25.3|6879326|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT
CTCATCACGCGTGGCGAGTGGGAGCCGGGCCGC
>25.4|6879387|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT
GAGGACGCCGTTGGTGTCGCCGGCGTACGGCTG
>25.5|6879448|35|NZ_CP045178|CRISPRCasFinder
TGCCCTCGACACGGCGCACGTCCGCCTGGCCGCGT

CRISPR arrays and Neighbor proteins around NZ_CP045178_25

CRISPR arrays

The CRISPR arrays of NZ_CP045178_25

>merge|NZ_CP045178|25|6879176-6879510|PILER-CR,CRISPRCasFinder,CRT
GTCGCCCCCGCGCCTGCGGGGATGTTCCGTTCTCCAGCCGGGCGTTGCGGATCTTGGCGCGGTCGCCCCCGCGCCTGCGGGGATGTTCCGCGCTGCTCGGGGCGGTACTACACCGTCCCGAGGTCGCCCCCGCGCCTGCGGGGATGTTCCCTCATCACGCGTGGCGAGTGGGAGCCGGGCCGCGTCGCCCCCGCGCCTGCGGGGATGTTCCGAGGACGCCGTTGGTGTCGCCGGCGTACGGCTGGTCGCCCCCGCGCCTGCGGGGACGTTCCTGCCCTCGACACGGCGCACGTCCGCCTGGCCGCGTTACCCCCCGGCGTCTGCCGGGATGCCCC

>NZ_CP045178|25|4|6879176-6879447|PILER-CR
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GTTCTCCAGCCGGGCGTTGCGGATCTTGGCGCG
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GCGCTGCTCGGGGCGGTACTACACCGTCCCGAG
GTCGCCCCCGCGCCTGCGGGGATGTTCC	CTCATCACGCGTGGCGAGTGGGAGCCGGGCCGC
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GAGGACGCCGTTGGTGTCGCCGGCGTACGGCTG
GTCGCCCCCGCGCCTGCGGGGACGTTCC

>NZ_CP045178|25|20|6879176-6879510|CRISPRCasFinder
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GTTCTCCAGCCGGGCGTTGCGGATCTTGGCGCG
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GCGCTGCTCGGGGCGGTACTACACCGTCCCGAG
GTCGCCCCCGCGCCTGCGGGGATGTTCC	CTCATCACGCGTGGCGAGTGGGAGCCGGGCCGC
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GAGGACGCCGTTGGTGTCGCCGGCGTACGGCTG
GTCGCCCCCGCGCCTGCGGGGACGTTCC	TGCCCTCGACACGGCGCACGTCCGCCTGGCCGCGT
TACCCCCCGGCGTCTGCCGGGATGCCCC

>NZ_CP045178|25|5|6879176-6879447|CRT
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GTTCTCCAGCCGGGCGTTGCGGATCTTGGCGCG
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GCGCTGCTCGGGGCGGTACTACACCGTCCCGAG
GTCGCCCCCGCGCCTGCGGGGATGTTCC	CTCATCACGCGTGGCGAGTGGGAGCCGGGCCGC
GTCGCCCCCGCGCCTGCGGGGATGTTCC	GAGGACGCCGTTGGTGTCGCCGGCGTACGGCTG
GTCGCCCCCGCGCCTGCGGGGACGTTCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077967626.1|6885408_6886365_+|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
NZ_CP045178.1|WP_077967628.1|6886361_6887210_+|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
NZ_CP045178.1|WP_077967669.1|6880131_6880317_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077967668.1|6869902_6870241_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224639
NZ_CP045178.1|WP_077967592.1|6872415_6873750_+|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|223110
NZ_CP045178.1|WP_077967595.1|6873753_6874962_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|99746
NZ_CP045178.1|WP_077967591.1|6870796_6872419_+|diaminopimelate-decarboxylase	unknown	unknown	gnl|CDD|143509
NZ_CP045178.1|WP_077967611.1|6882599_6882908_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077967605.1|6878005_6878596_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_143621223.1|6876929_6877367_+|BON-domain-containing-protein	unknown	unknown	gnl|CDD|236880
NZ_CP045178.1|WP_077967607.1|6880328_6881747_+|hypothetical-protein	unknown	unknown	gnl|CDD|234572
NZ_CP045178.1|WP_077967609.1|6881793_6882348_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379883
NZ_CP045178.1|WP_077967615.1|6884089_6885409_+|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270303
NZ_CP045178.1|WP_077967590.1|6869018_6869906_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
NZ_CP045178.1|WP_143621226.1|6877261_6877675_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077967630.1|6887327_6888539_+|D-galactonate-dehydratase-family-protein	unknown	unknown	gnl|CDD|237901
NZ_CP045178.1|WP_077967599.1|6875867_6876803_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
NZ_CP045178.1|WP_077967671.1|6888770_6889250_+|N-acetyltransferase	unknown	unknown	gnl|CDD|224168
NZ_CP045178.1|WP_077967597.1|6875112_6875871_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
NZ_CP045178.1|WP_077967613.1|6883034_6883820_+|FadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225097

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077967626.1|6885408_6886365_+|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	4.76936e-80
NZ_CP045178.1|WP_077967628.1|6886361_6887210_+|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	6.41197e-70
NZ_CP045178.1|WP_077967607.1|6880328_6881747_+|hypothetical-protein	gnl|CDD|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	2.48753e-158
NZ_CP045178.1|WP_077967592.1|6872415_6873750_+|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|223110	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism].	4.09164e-74
NZ_CP045178.1|WP_077967595.1|6873753_6874962_+|aminotransferase-class-V-fold-PLP-dependent-enzyme	gnl|CDD|99746	cd06453, SufS_like, Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.	6.60896e-89
NZ_CP045178.1|WP_077967591.1|6870796_6872419_+|diaminopimelate-decarboxylase	gnl|CDD|143509	cd06842, PLPDE_III_Y4yA_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA. This subfamily is composed of the hypothetical Rhizobium sp. protein Y4yA and similar uncharacterized bacterial proteins. These proteins are homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC). ODC and DapDC are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases. ODC participates in the formation of putrescine by catalyzing the decarboxylation of ornithine, the first step in polyamine biosynthesis. DapDC participates in the last step of lysine biosynthesis, the conversion of meso-2,6-diaminoheptanedioate to L-lysine. Proteins in this subfamily may function as PLP-dependent decarboxylases.	6.28891e-150
NZ_CP045178.1|WP_077967597.1|6875112_6875871_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.53319e-15
NZ_CP045178.1|WP_143621223.1|6876929_6877367_+|BON-domain-containing-protein	gnl|CDD|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	4.06802e-37
NZ_CP045178.1|WP_077967668.1|6869902_6870241_-|GntR-family-transcriptional-regulator	gnl|CDD|224639	COG1725, COG1725, Predicted transcriptional regulators [Transcription].	2.64423e-19
NZ_CP045178.1|WP_077967609.1|6881793_6882348_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	3.26327e-16
NZ_CP045178.1|WP_077967615.1|6884089_6885409_+|sugar-ABC-transporter-substrate-binding-protein	gnl|CDD|270303	cd13585, PBP2_TMBP_like, The periplasmic-binding component of ABC transport systems specific for trehalose/maltose and similar oligosaccharides; possess type 2 periplasmic binding fold. This family includes the periplasmic trehalose/maltose-binding component of an ABC transport system and related proteins from archaea and bacteria. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.37253e-57
NZ_CP045178.1|WP_077967613.1|6883034_6883820_+|FadR-family-transcriptional-regulator	gnl|CDD|225097	COG2186, FadR, Transcriptional regulators [Transcription].	5.75915e-49
NZ_CP045178.1|WP_077967630.1|6887327_6888539_+|D-galactonate-dehydratase-family-protein	gnl|CDD|237901	PRK15072, PRK15072, D-galactonate dehydratase family protein.	0
NZ_CP045178.1|WP_077967599.1|6875867_6876803_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.54371e-08
NZ_CP045178.1|WP_077967671.1|6888770_6889250_+|N-acetyltransferase	gnl|CDD|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	5.03049e-40
NZ_CP045178.1|WP_077967590.1|6869018_6869906_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.15566e-68

Protein sequences

>NZ_CP045178.1|WP_077967605.1|6878005_6878596_+|hypothetical-protein
MVHLVLRHLSLPVHGNTYVRGVLPPQGGEEAVCVAVGKKDACAPDLNIYEIPLIQDEIIIAADEVLRIVRVAQTADPFYRTFYRDDEGDLSQMPSLALDLLDIRGDQEQQEPAVLTPETTHSTDRASLVGMLPLAPGRHRLYWSCGDWPGIIASDAETSDSPEALRTVAVHGLPDTRHAQPSKDLYCWKIAPLLEF
>NZ_CP045178.1|WP_143621226.1|6877261_6877675_-|hypothetical-protein
MRVDDAERFDCGRGDVGAPYPRAALTARHGRSPPPTPSTTQAMAGTAHTPMPEVGRLGQQKASGRHPGPEAGEAGEQIVALERWSERLDAFGNVEEHPVRRPLYAGARRTQPPHTWSRLDTIGSLARRRLAPAFGSP
>NZ_CP045178.1|WP_143621223.1|6876929_6877367_+|BON-domain-containing-protein
MTMYEFDKSVGQPLDAPLHGEGAEAAKQLKHRLEALGLTHDHFLVEVDGSKVTVSGDAAMQDQKERILLALGNTEGVAQVEDLVDAGQEELRPRFVTVRDGETLSDLAERLYGDPNAGANLLRANEPMVSSLDQVCGGWVLRAPA
>NZ_CP045178.1|WP_077967599.1|6875867_6876803_+|GNAT-family-N-acetyltransferase
MSNGPMSNGPLSNGPMSHGPSSRAPSGPRPVDSRSARTGPAGAPSAGALAGPDSNPCAYLSHLGTSAHVRLDREPDHALLTAPTVARPFNTVFAPAFAVEGLDRRLREVADTHAARAPAAMWWIGPSSTPAALPEALVARGYERISPVRLMSASREAGLPDSTGPDRPGGGVDVRPVTCREELADFVAVHLAAYAMAPEEAHFTLRVLGSLSLAEDAPLRHFLVRRAGTALAAASVFAHDGLGGLYNIATVPRARRMGLATLATRAALAEAYGRGVRAVMLGAEPGAVGMYRRLGFREGAELTRLVPRPSR
>NZ_CP045178.1|WP_077967597.1|6875112_6875871_+|class-I-SAM-dependent-methyltransferase
MSLNTATAAQWVERWDRQQQRYAFDREERFTVVADVVEHVTAGRSAPAVADLGCGPGSMAVRLSRRLPQARVIAVDMDPLLLELGRTLEEGMIRYVEAVIGEDGWTDALGLDQPLDAAVSTTAFHYLPAAVLQRVYTQLAAILRPGGVLVNADHLQQEAAADIAAHVGRRRATRQSAFAHEDWESWWAAAERDPALTHLFNERRRRRGSRGDTSAGNGLTLSRHTAMLRAAGFAQAGPVWQVGNSCVLVAVR
>NZ_CP045178.1|WP_077967595.1|6873753_6874962_+|aminotransferase-class-V-fold-PLP-dependent-enzyme
MHVTSAGEQRLLEWLADWQAPLRAQFPIIVAHPELVYLDSAATAQKPQAVLDAALTYLTTSNANAGRGTYPWANRTTELLERTRGRVKRFLGDPAPERSRVDFFSGATEGLRSVALDWLPRLLADGDEIIVPFGDHQANLLPWLEAQKLLAERGVHITVRELPCQAGSHDYDTEALARLAGPRTRFVAVTHVHHVYGADMNIHRVRAAVGPDVPICLDAAQSVGHLPLSLAELDVDLLVFSGHKTLALPGTGAVWSREARGPGFAPSGWRGTPNTVGVASLERALDWLDAADVGRVGEWTSALSARLTEGLRHLGQYEVLGCGRSLAADSEVQRRAGIVTFRHELIDSMDLGFILYSHGFMVRSDDHCQGYAGERDPSVRVSPHVYNTPEEIDRLLEVLAEL
>NZ_CP045178.1|WP_077967592.1|6872415_6873750_+|pyridoxal-phosphate-dependent-enzyme
MRYDSVTDIIGRTPLLRIHPEVHGLRNIDLYAKLELLNPFGSLKDRAAWNMVRPGLDAAVERGSRIVELSSGNTAKALALIAGVHGLGFKSVTNRMKVPEIKELLLLLGAEIEELPGQTECLDPTNPEDPLTRFHRALSEPGSDYLHTDQYYNPRNAQAHAEGTGPEIVADLDGRAPDWFIAAVGTAGSSSGVARALRRTDPDVEVVGLVAHKSDFVPGIRNIDEIQEVGLFDPSLYTTIDPVTSDEAIDGMLELARRSGVLSGPTGGAAYFGALRHLRPLDAALTERGSTERKSAVFIVCDRIESYLSYIRRRRPELFGGQVRKNSLTALTPDEVRAAPAMDIEDAQHWIKTERPLVIDLRSPFAYAALHMEGAVNIADELLEEMVRGGLPFSKRQPVLLTCPVGERSAQYAALLTRLGHPDARSLAGGIVAWRDAGAQLVRE
>NZ_CP045178.1|WP_077967591.1|6870796_6872419_+|diaminopimelate-decarboxylase
MNHDRGDRHTVGGALYLEPRLEPPLASLIEDSGFLHQLVGGLGSPLNVLLPQVIAGNVESFRQVYRERRLRGEILFAHKANRSSALVRQLAATEADIDVASLEELQHALGAGFSAGRIGATGPKDPDFLWLGARAGVTFHVDGRSELEELISLVRRCGLPRVRVLPRLSGFTSSGVRRLARLSRFGTPAADTEALLDLLESAQDAVELIGFGYHLDTVSLDEKAVALEGCVAVMDHCAGRGMRPRTIDVGGGFGVSYLAEADQWNTYTTELTRAVMGTRPPLTWRGHGYGLRNDMGTLAGALSLYPAHREQAGAEYLAALFDMEGPVSGRPLGSLLLEGLYDVRVAPGRALVDQCGLTLARVMEVGRVGAGPATHQPGESGADWFVRLGMNASDCSLEDHGVLMDPLIVPAGGPRTGEPRAGEARAGGPHTGGARAGVTRDDAEGPRAAGEGPVAVHLFGNLCLEADLITKRAVHLPHLPVPGDLLCFANTAGYCMDFSAHRAERRPEARKVAVHLDAEGHRSWRLDEDYWPMATAGERA
>NZ_CP045178.1|WP_077967668.1|6869902_6870241_-|GntR-family-transcriptional-regulator
MQIVQQTQRALRLGLLEPGDRLPTAREVVEVTAINPNTVLKAYRELERQGLVAGRRGLGTFVLRPLDSTADSPLGAALDDWARRALASGIDREGAAEFMDAALDKHFPKEEQ
>NZ_CP045178.1|WP_077967590.1|6869018_6869906_-|ABC-transporter-ATP-binding-protein
MSLSSATPAVIEANGVTHRHGRGRRATHALRECSFRVPEGSVCALVGPNGAGKTTLLRIVAGLVRPTSGSVGVLGAAPGTHRDRVGYLDQSQPLHENLSVADTLTMGARLNSGHWDARYAADIVAAGGLDPQRGVRGLSGGQRTRLSLALALGKRPELLLLDEPMAGLDPLARRELMGVLLADAAERGTSVLLSSHVVAELAEACDHLLLIGGGRVRLGGSIDALLAAHRVVTSMDGDLSPHTVIESRPSGRGLTTLIRPRGPVRAAVRPEEPRLEEVILAHLRTPSAPALLLPD
>NZ_CP045178.1|WP_077967669.1|6880131_6880317_+|hypothetical-protein
MPSTDLSPDDIARLAARAGLPLDASRAPAVAATVNAIHGVVGALGELRLGETAPASSFDAR
>NZ_CP045178.1|WP_077967607.1|6880328_6881747_+|hypothetical-protein
MTHPYELTLSEAADAVADRSLSPVELTTSVLGRIGETDPATGAYVTVTAESALADAARAADDIAAGRHLGPLHGIPMALKDLIDTAGVPTTASSLVRADHVPSQDAAVTARLRAAGAVLTGKTHTHEFAYGTTTPQTRNPWDTGRTPGGSSGGSAAAVASGAATFALGTDTGGSIRIPAALTGIVGLKPTYGLVPRRGVASLSWSLDHVGPLTRTVRDAALVLDALAGYDPSDNASIDHPREEYGRLLGRDLKGLRVGVPVNYYFDRVQPDVENTVRAAIDALTGLGAVPVPVEIPMAEYVRAVHWGLMVPEATAYHQDSLRTSPELYTDDVRILLEAGEFVPATDYIRAQRARTLMRQSWQELFERVDVVAAPTVTSTAAPAHLPNLLWADGSEEGVSDSYVRLSAPANLTGLPSLSVPVGFDGDGLPIGMQVIGGPLDEARLIQVGHAYESAHRPVAHLAPLVTSAGAAG
>NZ_CP045178.1|WP_077967609.1|6881793_6882348_-|TetR/AcrR-family-transcriptional-regulator
MPVTPATRPGGRSARVQRSVHDAVRELVDERGREGLTVPMVAARASVTPSTVYRRWGDLHELLADVAVERLRPEAPPKDHGALRDDLHAWAEQFLDEMASPAGRAYIRDALSGDPDGRNAGQCSAYAAQQLKVMLERAAERDEPAPGLEEAMDRVVAPMMYRVLFRPSPLTAEYARSLVDSLLP
>NZ_CP045178.1|WP_077967611.1|6882599_6882908_+|hypothetical-protein
MSGNKPLNAVAGNLFARLYLAVCVLLLIWVAVDSTLVPHEDASFAGVVPLILTAPFSLVVLALPINGLAGVLLPIAAGAVVNAWLITRIGRATGSTRHRAGA
>NZ_CP045178.1|WP_077967613.1|6883034_6883820_+|FadR-family-transcriptional-regulator
MPSPTPSAHAHRGLLTERIARQLEHDIRSGAIAVGTKLPSERELAAQFGSSRNVVREVLRRLEAQHLIEVAPGRGSFVREQSSGQARGYDALYRAGRPTVRQLIEARLPLEVETVRLATERASEADIEVMRRAVDTLESASDVVVKAQADMDFHDAVATASGNPVLRIMLSSISGMMFEMMLRSNSDPSIGEPGVPHHPEIFEAIEARDVGLACERMRSHLMLGLRTYGADLDVPVNVMARHHIEALLAESEGRRGGTTLA
>NZ_CP045178.1|WP_077967615.1|6884089_6885409_+|sugar-ABC-transporter-substrate-binding-protein
MSTSRQSPSRRSFGRLAAGVAGAAGLAAISGCAPGAGKPSRSTPLRIMAINHVWSQAIRRRTKEFEERIGRRVSMTLLTADQLASSYNVKLNASGTDVDVMMVRALQEQLVFAHNGWLTDLTDRVKGDADFGWSDFQKAPRDASVTSGKVLSVPVVTERPALYYRKDLVEDLGGPPKTLDALLHASLELTDRRKNFYGYVGRGQRNGAVSQWSSFLYSHGGDFVVEGKSAIGSPEALAAYEYYGKLLAKAGPPGATNMSLEQAMPIFAQGKAAFYIDADAIYSSFLDPKNSTVRETVGFAPFPAGPAGARPHNIPSWSLGINRFSLLRDDAWEFIRWASSPKMVAALQADGIPGARASAWADRKTLASFPPQLAEAMRVNAERGLGYDRPRVLQVGRARDIVGRPLVAGILGNRVEPVVRDADAEFADFLVRDNRHKES
>NZ_CP045178.1|WP_077967626.1|6885408_6886365_+|sugar-ABC-transporter-permease
MTTTEVSPGRSDTLAPRQPNRRPPRTFEQANRRLKWTMLAPALLFVGLMIVFPLFFTLDLSFTDAFGAVNAGKDHVGLRNFTDALGDARRFWPAARRTVLFTVGAVVLETALGLALAMLMRKPFRGMRWVRTILIIPLLTTPVAIGILWLLILDPTNGIANHLLSGIGLPPQEFLGSVSQSLPTLMLIDVWQWTPMMTLLLLAGLTTLPEEPEEAALVDGAGPWQRFRYVILPMLGPTLATALVLRAVDALKTFDILYATKGPGGGSDFEVETLNVYAYGLTFDYQEYGLAAAVLVLFTLFIVGVVVLLRRRSGKGGA
>NZ_CP045178.1|WP_077967628.1|6886361_6887210_+|carbohydrate-ABC-transporter-permease
MSAAASPVARRTARRTYAGWLRGLAIAVVTLIFALPVIWMFAAAFKTNVQVTDPSVGLWFKPTLDNFRSIVEAGQIVRSMGNSLLIGVVSTVLSAVIAVPAAWAVGRFSMHRTGSLILVARIVPAISLLVPWYYLFAKAGLVGSYTVLILSHMFVSVPLIMWIMISFFAGLPVELEEAARTDGLSAFGAFWRITLPLAAPGTATASLLAFVFSWNNFMFALVFADDRTQTVPVTLFNFISYASTDWGGLMAAATLITVPVVLAAILGQKYLVAGLTSGATKG
>NZ_CP045178.1|WP_077967630.1|6887327_6888539_+|D-galactonate-dehydratase-family-protein
MKIVDAKVVVTSPGRNFVTLRITTDEGLTGLGDATLNGRELAVVSYLRDHVAPLLIGLDPHRIEDTWQSLYRGAYWRRGPVTMAAIAAVDVALWDIKAKAAGLPLYQLLGGASRDRVATYGHASGRDLPELFDSVRQKLELGYPAIRIQTGVPGLRTVYGVGGSAAAPADPTGHPRPVVEDWDTAAYLRHLPTVFEAVRSEFGAELPLLHDAHHRLTPVQAGRLGKELEPYRLFWLEDCTPAENQEALRLVRGNTVTPLAIGEVFNTVHDYQALITEQLIDYARSAVTHFGGISPLRKLFDFAAQYQVKSAVHGPEDISPVGMAAAVHLDLAVHNFGIQEYAGHTPLTEEVFRHAYTFTDGHLHPGEAPGIGVELDEELAAAHPYKPDYLPVNRLQDGTVHDW
>NZ_CP045178.1|WP_077967671.1|6888770_6889250_+|N-acetyltransferase
MGRGHAQRVLAIHQAGIEEGEATFETAAPTWEEFDSAELGAHRFVALADDGEVLGWVAVSAVSARSAYAGLVEHSVHVHREARGGGVAGALLERLITSTEAAGVRTIQSGIFPESTASLALHQRAGFRLIGTRERVGRLRGVRRDVLLLERRSPVGRLT

Crispr_ID: NZ_CP045178_26

• CRISPR_ID: NZ_CP045178_26
• CRISPR_location: 7112950-7113048
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_26

Consensus_repeat	Method
TGACGCCCGTCACCCCGACGGGCGT	CRISPRCasFinder

spacers of NZ_CP045178_26

>26.1|7112975|49|NZ_CP045178|CRISPRCasFinder
CACCCCGACGGGCGTCACGCCGACGTCCGTCACGTTGAGGCCATCACGT

CRISPR arrays and Neighbor proteins around NZ_CP045178_26

CRISPR arrays

The CRISPR arrays of NZ_CP045178_26

>merge|NZ_CP045178|26|7112950-7113048|CRISPRCasFinder
GTGCGCCCGTCGCGCTGACGCCCGTCACCCCGACGGGCGTCACGCCGACGTCCGTCACGTTGAGGCCATCACGTTGAGGCCCGTCACCCCGACGGGCGT

>NZ_CP045178|26|21|7112950-7113048|CRISPRCasFinder
GTGCGCCCGTCGCGCTGACGCCCGT	CACCCCGACGGGCGTCACGCCGACGTCCGTCACGTTGAGGCCATCACGT
TGAGGCCCGTCACCCCGACGGGCGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_107502704.1|7108452_7110000_-|acyl-esterase	unknown	unknown	gnl|CDD|334820
NZ_CP045178.1|WP_077965502.1|7114069_7114276_-|hypothetical-protein	unknown	unknown	gnl|CDD|212683
NZ_CP045178.1|WP_077965913.1|7100758_7102045_+|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|131480
NZ_CP045178.1|WP_107502677.1|7113106_7113805_-|PepSY-domain-containing-protein	unknown	unknown	gnl|CDD|377032
NZ_CP045178.1|WP_077965510.1|7117634_7119035_+|dihydropyrimidinase	unknown	unknown	gnl|CDD|236240
NZ_CP045178.1|WP_077965512.1|7119051_7120083_+|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|163554
NZ_CP045178.1|WP_077965495.1|7110419_7110767_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077965517.1|7122528_7123221_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
NZ_CP045178.1|WP_077965486.1|7105880_7106789_+|glutamate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|270408
NZ_CP045178.1|WP_077965914.1|7102069_7102705_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|316044
NZ_CP045178.1|WP_077965488.1|7106855_7107500_+|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NZ_CP045178.1|WP_077965506.1|7115320_7116163_+|acyltransferase	unknown	unknown	gnl|CDD|143592
NZ_CP045178.1|WP_077965484.1|7105123_7105867_+|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224051
NZ_CP045178.1|WP_077965481.1|7098898_7100296_+|serine/threonine-protein-kinase	unknown	unknown	gnl|CDD|270916
NZ_CP045178.1|WP_077965508.1|7116159_7117443_+|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|99735
NZ_CP045178.1|WP_077965482.1|7102798_7103578_+|exodeoxyribonuclease-III	unknown	unknown	gnl|CDD|197320
NZ_CP045178.1|WP_077965490.1|7107496_7108402_+|amino-acid-ABC-transporter-permease	unknown	unknown	gnl|CDD|223836
NZ_CP045178.1|WP_107502678.1|7120157_7121174_-|DNA-binding-protein	unknown	unknown	gnl|CDD|130981
NZ_CP045178.1|WP_077965504.1|7114689_7115091_+|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274712
NZ_CP045178.1|WP_077965515.1|7121386_7122532_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_107502704.1|7108452_7110000_-|acyl-esterase	gnl|CDD|334820	pfam02129, Peptidase_S15, X-Pro dipeptidyl-peptidase (S15 family).	2.7054e-38
NZ_CP045178.1|WP_077965502.1|7114069_7114276_-|hypothetical-protein	gnl|CDD|212683	cd11733, HSPA9-like_NBD, Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins. This subgroup includes human mitochondrial HSPA9 (also known as 70-kDa heat shock protein 9, CSA; MOT; MOT2; GRP75; PBP74; GRP-75; HSPA9B; MTHSP75; the gene encoding HSPA9 maps to 5q31.1), Escherichia coli DnaK, and Saccharomyces cerevisiae Stress-Seventy subfamily C/Ssc1p (also called mtHSP70, Endonuclease SceI 75 kDa subunit). It belongs to the heat shock protein 70 (HSP70) family of chaperones that assist in protein folding and assembly, and can direct incompetent "client" proteins towards degradation. Typically, HSP70s have a nucleotide-binding domain (NBD) and a substrate-binding domain (SBD). The nucleotide sits in a deep cleft formed between the two lobes of the NBD. The two subdomains of each lobe change conformation between ATP-bound, ADP-bound, and nucleotide-free states. ATP binding opens up the substrate-binding site; substrate-binding increases the rate of ATP hydrolysis. Hsp70 chaperone activity is regulated by various co-chaperones: J-domain proteins and nucleotide exchange factors (NEFs); for Escherichia coli DnaK, these are the DnaJ and GrpE, respectively. HSPA9 is involved in multiple processses including mitochondrial import, antigen processing, control of cellular proliferation and differentiation, and regulation of glucose responses. During glucose deprivation-induced cellular stress, HSPA9 plays an important role in the suppression of apoptosis by inhibiting a conformational change in Bax that allow the release of cytochrome c. DnaK modulates the heat shock response in Escherichia coli. It protects E. coli from protein carbonylation, an irreversible oxidative modification that increases during organism aging and bacterial growth arrest. Under severe thermal stress, it functions as part of a bi-chaperone system: the DnaK system and the ring-forming AAA+ chaperone ClpB (Hsp104) system, to promote cell survival. DnaK has also been shown to cooperate with GroEL and the ribosome-associated Escherichia coli Trigger Factor in the proper folding of cytosolic proteins. S. cerevisiae Ssc1p is the major HSP70 chaperone of the mitochondrial matrix, promoting translocation of proteins from the cytosol, across the inner membrane, to the matrix, and their subsequent folding. Ssc1p interacts with Tim44, a peripheral inner membrane protein associated with the TIM23 protein translocase. It is also a subunit of the endoSceI site-specific endoDNase and is required for full endoSceI activity. Ssc1p plays roles in the import of Yfh1p, a nucleus-encoded mitochondrial protein involved in iron homeostasis (and a homolog of human frataxin, implicated in the neurodegenerative disease, Friedreich's ataxia). Ssc1 also participates in translational regulation of cytochrome c oxidase (COX) biogenesis by interacting with Mss51 and Mss51-containing complexes.	0.0093664
NZ_CP045178.1|WP_077965913.1|7100758_7102045_+|alpha/beta-fold-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	8.23813e-74
NZ_CP045178.1|WP_107502677.1|7113106_7113805_-|PepSY-domain-containing-protein	gnl|CDD|377032	pfam03413, PepSY, Peptidase propeptide and YPEB domain. This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase & Bacillus subtilis YPEB.	4.54678e-09
NZ_CP045178.1|WP_077965510.1|7117634_7119035_+|dihydropyrimidinase	gnl|CDD|236240	PRK08323, PRK08323, phenylhydantoinase; Validated.	0
NZ_CP045178.1|WP_077965512.1|7119051_7120083_+|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase	gnl|CDD|163554	TIGR03842, F420_CPS_4043, F420-dependent oxidoreductase, CPS_4043 family. This model represents a family of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, TIGR03555), both within the bacterial luciferase-like monoxygenase (LLM) family. A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial clade, in which the member is often the only apparent F420-dependent LLM family member. The specific function, and whether Actinobacterial and Proteobacterial clades differ in function, are unknown. [Unknown function, Enzymes of unknown specificity].	0
NZ_CP045178.1|WP_077965517.1|7122528_7123221_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	8.53146e-67
NZ_CP045178.1|WP_077965486.1|7105880_7106789_+|glutamate-ABC-transporter-substrate-binding-protein	gnl|CDD|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.2006e-87
NZ_CP045178.1|WP_077965914.1|7102069_7102705_+|MBL-fold-metallo-hydrolase	gnl|CDD|316044	pfam13483, Lactamase_B_3, Beta-lactamase superfamily domain. This family is part of the beta-lactamase superfamily and is related to pfam00753.	9.18905e-25
NZ_CP045178.1|WP_077965488.1|7106855_7107500_+|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.70303e-53
NZ_CP045178.1|WP_077965506.1|7115320_7116163_+|acyltransferase	gnl|CDD|143592	cd07568, ML_beta-AS_like, mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases). This family includes mammalian-like beta-AS (EC 3.5.1.6, also known as beta-ureidopropionase or N-carbamoyl-beta-alanine amidohydrolase). This enzyme catalyzes the third and final step in the catabolic pyrimidine catabolic pathway responsible for the degradation of uracil and thymine, the hydrolysis of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyrate to the beta-amino acids, beta-alanine and beta-aminoisobutyrate respectively. This family belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 5. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. Beta-ASs from this subgroup are found in various oligomeric states, dimer (human), hexamer (calf liver), decamer (Arabidopsis and Zea mays), and in the case of Drosophila melanogaster beta-AS, as a homooctamer assembled as a left-handed helical turn, with the possibility of higher order oligomers formed by adding dimers at either end. Rat beta-AS changes its oligomeric state (hexamer, trimer, dodecamer) in response to allosteric effectors. Eukaryotic Saccharomyces kluyveri beta-AS belongs to a different superfamily.	3.30504e-151
NZ_CP045178.1|WP_077965484.1|7105123_7105867_+|amino-acid-ABC-transporter-ATP-binding-protein	gnl|CDD|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	7.65572e-148
NZ_CP045178.1|WP_077965481.1|7098898_7100296_+|serine/threonine-protein-kinase	gnl|CDD|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	9.29933e-83
NZ_CP045178.1|WP_077965508.1|7116159_7117443_+|aspartate-aminotransferase-family-protein	gnl|CDD|99735	cd00610, OAT_like, Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, alanine-glyoxylate aminotransferase, dialkylglycine decarboxylase, 4-aminobutyrate aminotransferase, beta-alanine-pyruvate aminotransferase, adenosylmethionine-8-amino-7-oxononanoate aminotransferase, and glutamate-1-semialdehyde 2,1-aminomutase. All the enzymes belonging to this family act on basic amino acids and their derivatives are involved in transamination or decarboxylation.	6.30897e-130
NZ_CP045178.1|WP_077965482.1|7102798_7103578_+|exodeoxyribonuclease-III	gnl|CDD|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	1.1654e-111
NZ_CP045178.1|WP_077965490.1|7107496_7108402_+|amino-acid-ABC-transporter-permease	gnl|CDD|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.20501e-57
NZ_CP045178.1|WP_107502678.1|7120157_7121174_-|DNA-binding-protein	gnl|CDD|130981	TIGR01926, peroxid_rel, uncharacterized peroxidase-related enzyme. This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.	9.66963e-06
NZ_CP045178.1|WP_077965504.1|7114689_7115091_+|PPOX-class-F420-dependent-oxidoreductase	gnl|CDD|274712	TIGR03666, Rv2061_F420, PPOX class probable F420-dependent enzyme, Rv2061 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	2.87176e-41
NZ_CP045178.1|WP_077965515.1|7121386_7122532_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.9165e-41

Protein sequences

>NZ_CP045178.1|WP_077965495.1|7110419_7110767_-|hypothetical-protein
MKIFGYEPVVLLHTLSAVLGLVVSLGLTGLSPEAAAAIVGFATALLGAAAAWMTRPIAPAAFTAVVSAGAVLVAAFGYDVSQATIGAINAAVLSALTLVVRGSVSPTLRPSGTAV
>NZ_CP045178.1|WP_107502704.1|7108452_7110000_-|acyl-esterase
MLLAGAAVTPAQAGDAPGTARAAQAAQATAGIRFVDIPGDGGTVLKANVVTPSGAAPAGGHPVVILPTSWAIPQVEYLAQAQKLADTGYVVVSYNSRGFWQSGGEIEVGGPKDIGDASKVIDWTLANTPANPGKVGMAGVSYGAGIGLLAAAHDPRVKAVAALSGWGDLIDSIYSGRTQHSQAAALLGGSGYLTGRPGPELQQILSDFLGSNLAKEDEMIAWGKKRSPSTYLDALNKNGAALLLGNAWGDTIFPPNQYADFFEKLTVPKRLELRPGDHATSELTGLLGLPNDTWTDTRRWFDHYLKGEDNGVDREQPVKISSRSGGGYENYPDWKSVGPDREKLDLAGTTTIHANVDSGANGGIVLLSNALDQLTRIPPIASVPLLPRRYAAVWQSEKYGTEQRVRGTAKLHTTLTSTKESGTLVAYLYDVGPLGLGKLVSNAPYTFHGKTPGRPFGVDLELFSTAYDVPAGHRLAMVVDTVDPLYIEHNPSGAQLTFSSPAADPSYLSVPLREQ
>NZ_CP045178.1|WP_077965490.1|7107496_7108402_+|amino-acid-ABC-transporter-permease
MSGVFSLHGSTGASALYDVPGPRTRRRHTLYGLLSTLVILALLGWLLYLLFDTDQFTAEKWTPFEYKGIQELLLRGLGNTLKAFAISAVLALALGALLAAGRLSDHRPVRWVSTVLVEFFRAMPVLVMIFFVFVALKVQPLPALVTGLTLYNGSVLAEVFRSGVNSVERGQREAAYALGMRKTQVMSHVLVPQAVRAMLPSIISQLVVALKDTSLGFLITYEEFLHAGKLIASNLDYDLPFIPVVMVISPIYIGMCMVLSWLAHWVAARERRSPKTEAVDLVPAAPGTLLPGGGPSTSSRE
>NZ_CP045178.1|WP_077965488.1|7106855_7107500_+|amino-acid-ABC-transporter-permease
MDVLTENFSDYGKGFLGTVELTVYASVLALVLGFVMASFRVAPVGSLRVFGTAWVTVLRNTPLTLLFFAVLLGLPRFGLVLPFQLFAVLALGCYTSAFICEALRSGINTVPRGQGEAARSLGMTFGQTLVFVILPQAFRSVISPVGSNLIALAKNSAIAGAFSVTELLGTYKTLNELGYNIIWTFVWIAVGYLILTLALSAVFNVLEKHWGVAR
>NZ_CP045178.1|WP_077965486.1|7105880_7106789_+|glutamate-ABC-transporter-substrate-binding-protein
MRNRYSVRALTALLLTLAALAGCGKEGSPPVKGPRADQLPKYRVAREFRLADSPTWRAARARGHLVVGAKEDQPYLGEKDPSGGGYTGFDIEIAKMISAGLGFAPSTISFRTIASANRETSLQNGQIDYYVGTYTINANRKKSVGFGGPYYMAGQGLLVRTDEDSIHGPHDLAGRRVCSAAGSTPYQRIQKDHPEARLVSYDTYSICVDNLLTYQVDAVTTDDSILLGYAAKVPEELKVTGKPFSKEPYGVGLPKNDTALRFAVDDILAAGERDGDWKKAYEATLGLSGVPAPKPPPIDRYR
>NZ_CP045178.1|WP_077965484.1|7105123_7105867_+|amino-acid-ABC-transporter-ATP-binding-protein
MAVDPLIELRGVNKYYGELHVLQDIDLTVARGEVVVVIGPSGSGKSTLCRVVNRLETIQSGTIRVDGRPLPEEGKALAGLRAEVGMVFQSFNLFAHKTVLQNVSLAQMKVRGRKREEADHRSRELLDRVGLSSQAAKLPAQLSGGQQQRVAIARALAMDPKVLLFDEPTSALDPEMINEVLEVMRRLARDGMTMVVVSHEMGFARSAANRVVFMSEGRVVEDRTPEDFFTRPESERARDFLSKILKH
>NZ_CP045178.1|WP_077965482.1|7102798_7103578_+|exodeoxyribonuclease-III
MRIATWNVNSITARLPRLLAWLEKSGTDVLCVQETKTTAEAFPAEALREVGYESAVNATGRWNGVALISRVGLDDVVPGLPGGPDYDGVTEPRAISATCGPVRLWSVYVPNGREVGHDHYTYKLRWFEALRAAVSDDAAGPRPFAVLGDYNVAPTDDDVWDPTVFEDSTHVTAPERDALTALRSTGLSDVVPRPLKYERPYTYWDYRQLAFPKNRGMRIDLVYGNEPFAKAVSDSYVDREERKGKGASDHAPVVVDLDV
>NZ_CP045178.1|WP_077965914.1|7102069_7102705_+|MBL-fold-metallo-hydrolase
MELTKKTHACVRLEKAGRVLAIDPGVFTEEGAAVGADAILVTHEHPDHFSEGQLRAALEANPEAEIWTLRSVAEQISAAFPGRVHTVGHGDTFTAAGFDVQVHGELHAVIHPDIPRITNVGFLLDGSVFHPGDALTVPDRPVETLMLPVMAPWSKLSEVIDYVREVKPQRAYDVHDALLTDLARPVYDSQIGSLGGGAEHLRLASGESATI
>NZ_CP045178.1|WP_077965913.1|7100758_7102045_+|alpha/beta-fold-hydrolase
MSETTTETLQYRFDGPEQAPVLILGPSLGTTWHMWDRQIPELIRHWRVFRYDLPGHGGASAHPAGSVAELTDRLLATLDEAGVGRFGYAGCALGGAVGADLALRHPQRLASLALIAASPRFGTADEFRQRGVVVRTNGLDPIARSSPERWFTPGFAAAQPAITEWAVQMVRTTDPGCYISACEALASFDIRSELARIAAPTLVLVGSEDQVTGPAQARTLVAGIRDARLAVVPGASHLAPVEQPAAVTDLLVRHFTTAWQPEQAASPAAIVAPPVKPVISPPQQTGPVAEIAPFAVEEPAVRPDAYETGLKVRRAVLGDAHVDGVLDSADSFSEDFERFVTRYAWGEVWDRPGLDRRSRSCVTLTALVASGHLEELALHTKAALRNGLTPAEIKEVLIQAGVYCGVPAAAAAFKVAREVIQQETTPQE
>NZ_CP045178.1|WP_077965481.1|7098898_7100296_+|serine/threonine-protein-kinase
MSRRQARGARDEGGIGPGTDSALRRSDPVRIGPYQLLGRLGSGGMGKVYLGRSRTGHLAAVKVMHGEFTADPQFRTRFERELRAASRVSGRFTATVLESSRPVEERLWMATEYVPGPSLTQAVSAFGPLAPTTLLALWLGLLGALESIHAAGIVHRDLKPSNVLLAEDGPRLIDFGISALADASALTRTGMVVGTPGYMSPEEVRGDKSGPPSDVFALACTLMYAATGTGPFGGTNPMGVMYRIVHEEADLSRVPTRIVALISPCLDKDPLSRPSVTELINMLSGAETDEVSRLLAHGKWLPEDIRRRTRGHAERFFLGDGVRPSARPAAHPDHHEEGGPALHTGRFSEQRSQPDPTPQPDHTITRGLSGPGREPNAEPPTVSRSSVGAPPNGSPPNPPNPPNPPNPPNPPGPPDPYDTGGFEPDPTNEASLRTHTVPLSAELPPLPRIPRRTWLRWLPQRRGGR
>NZ_CP045178.1|WP_107502677.1|7113106_7113805_-|PepSY-domain-containing-protein
MNPTHRPAPRRRPARALATLVTVAACALTVTACGGSDGGGSDSGGQASGAASTNGSAASGSPSVSPTGSPSLDDDAREHADLLAATKVKAADAAKTALAVKSGTRLSELELERSGRGTPYWEGTLVEKDGTAFMVRVAADTGKAGALSGSDDNDSEDRSERMELLDASTITAAQAADKAAERSPGTPVHIDLDDERGRPVWQVSVVAPRTYQETEVDISAKDGNVLREKTED
>NZ_CP045178.1|WP_077965502.1|7114069_7114276_-|hypothetical-protein
MTHLAPTGAVPGLDWLLLIAALLATAVTCVAVPVRIEMSRGKQGKRAEPHEGARTGPPAVSHATPYEG
>NZ_CP045178.1|WP_077965504.1|7114689_7115091_+|PPOX-class-F420-dependent-oxidoreductase
MVLKELGSAKYVNITTYRKDGSAVATPVWVAPDGEKLIVWTRDDSWKVKRIKRDPRVEVAACDARGRVKEGAARAHGAAEVLPKSELTRARKLLSRKYTWQFWLLDTPATLFRRGKRPHVAISIALGAKAEAD
>NZ_CP045178.1|WP_077965506.1|7115320_7116163_+|acyltransferase
MADVVRAALVQATWTGDTESMIAKHEEHAREAARQGAKIIGFQEVFNAPYFCQVQDDEHYRWAERVPDGPTVTRMRELARETGLVIVVPVFEVEQSGFYFNTAAVIDADGSYLGKYRKHHIPQVKGFWEKFYFKPGNLGWPVFDTAAGRVGVYICYDRHFPEGWRQLGLNGAQIVYNPSATSRGLSAYLWQLEQPAAAVANAYYVAAINRVGQEEYGDNDFYGTSYFVDPRGQFVGDPAGDKTEELVVRDLDLALIDEVRHQWAFYRDRRPDAYQGLVNP
>NZ_CP045178.1|WP_077965508.1|7116159_7117443_+|aspartate-aminotransferase-family-protein
MTPLHARHRAVLPDWLALYYADPIEITHGEGRHVWDASGRKYLDFFGGILTTMTAHALPEVTKAVAEQAGRIVHSSTLYLNRPMVELAERVATLSGIPDARVFFTASGTEANDTALLLATAHRRSNQILAMRNSYHGRSFSAVGITGNGGWSPTSLSPLQTLYVHGGVRTRGPFAGLGDAEFTAACVADLKDLLGQVRGGVAALIAEPVQGVGGFTSPPDGLFAAFRDVLNEHGILWISDEVQTGWGRTGDNFWGWQAHGRSGPPDILTFAKGIGNGMSIGGVVASAEIMNCLDANSISTFGGSPVTLAAGLANLTYLLDHDLQGNARRVGGLLIERLRGAAARASYVREVRGRGLMIGVELARPSTGEAAPEAATAVLEAAREGGLLIGKGGGHDTSVLRIAPPLSLTVAEAEEGAAILDTALRGI
>NZ_CP045178.1|WP_077965510.1|7117634_7119035_+|dihydropyrimidinase
MNRTVIRGGLVVTAADEIHADVLVEDGRVAALAAHGTEAAEGFRAENTVDATGKYVIPGGVDGHTHMEMPFGGTFASDTFETGTRAAAWGGTTTVIDFAIQSKGGSLSEGLDTWHGKADGRCAIDYGFHMIMSDVNESSLKEMDRLVEAGVSSFKLFTAYPGVFLSDDGQILRAMQRAASNGGLVMTHAENGLAIDVLVEQALARGERDPRYHGEVRRALLEAEATHRVIRLSQVAGAPLYVVHVSAREALAELTRARDEGLPVFGETCPQYLFLSTDNLAEPDFDGAKYVCSTPLRPKDHQEALWRGLRTDDLQVVSTDHCPFCFKGQKEMGRGDFSRIPNGMPGVENRMDLLHQAVVEGHISRRRWIDLACAAPARMFGLYPKKGTIAPGADADIVIYDPHAEQIMSARTHHMNVDYSAYEGKRVTGRVETVLSRGVPVIENRAYVGHAGHGTYLPRGLCQYAD
>NZ_CP045178.1|WP_077965512.1|7119051_7120083_+|TIGR03842-family-LLM-class-F420-dependent-oxidoreductase
MDFGLVLQTDPPASAVVGLMRRAERNGFRYGWTFDSAVLWQEPFVIYSQVLEHTSKLVVGPMVTNPSTRTWEVTASTFATLNDMHGNRTVCGIGRGDSAMRVAGRKPNTLATLGSAIDAIRDLAEGRETDIDGRPVRLPWVKDGRLPVWMAAYGPKALALAGQRADGFILQLADPFLAASMIEAVRTAASDAGRDPASVTICVAAPGYVGDDLAHARDQCRWFGGMVGNHVADLVSRYGTESAAVPEELTSYIASREGYDYSHHGRAGNPSTDFVPDDVVDRFCLLGPAEAHIEKLRELRALGVDQFALYAMHDAREQAIDGYGQQIIPAVNRTPRGGGSGGP
>NZ_CP045178.1|WP_107502678.1|7120157_7121174_-|DNA-binding-protein
MAHPFRFTSPAPLAEATGATATLYAQIAEDFGIAYPPPLAALSPSPELLSATWALLRETLLAGDGSRTARQLIASGVSEANRCPFCVDAHALLLHATGERTLAVTLARGEVPGDPAQARLLDWGRATRVPGSPATWPLPFPQPLAPAYFGTALAFHFINRVVSALVDEELLHEEAELLRRTDQMEVRAVPDGGARIPVPGLSLPLLAGETGPAPAWATDTPVGTAYAALRSAALMGEGLLDDEDLALLGKAVAEWDGGHPDLASPGLPGRDRPGARLAALAALAPYRITAEDVEAWRGPHHTDHCLVHLIAYGAFAAVERIEAETWIDPRPAGDGAWS
>NZ_CP045178.1|WP_077965515.1|7121386_7122532_+|sensor-histidine-kinase
MAGEHADRAQADQEHAGQGLSARDQVAAGTAAVVVGAITGFAVSFGASPGVLDYALLSAGSLALAVQRRAPLLVLALTTLCLTGFVLHGHPAAIAALPVIGAVHTVSSIGRRGPGALASVVFLAGYLIAAPGDAEMAKKVGLLAGWFVCALVTGLAGKNWQAYLRQTEERALEAERTREEAGLRRAGEERLRIARELHDSLTHSISIIKLQAGVAAHLARKRGEEVPPSLLAIEEASGEAMRELRATLDVLRTDEPTGTPALLVERARGAGLAVSLRVSGRERPLSRGIDGTAYRVVQEALTNAARHAGGGEVRVELCYEERELVVSVDDDGSARPGRPVRAGVGLTGMGERVAAVGGTLCTGPREGGGFSVRAALPVEAP
>NZ_CP045178.1|WP_077965517.1|7122528_7123221_+|response-regulator-transcription-factor
MIRVALVDDQALMRAGFRALLEAEDGVEVVGEAADGAEGLALIRKVKPDIALVDVQMPVMNGIEMTRRLAAEPVLSGVRVVVLTNYGLDEYVFEALRAGAAGFLLKDTDPAGLLQGIAVVAGGESLLSPSVTGQLIRAYVSRPPDRHTAADVSVLTRREREVTALAARGLSNEEIAAHMVISPLTAKTHVSHAMTKLGARDRAQLVVFAYESGLVSPGGGPAGALPGRRP

Crispr_ID: NZ_CP045178_27

• CRISPR_ID: NZ_CP045178_27
• CRISPR_location: 7362359-7362442
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_27

Consensus_repeat	Method
GGGTGGAGCCACGGCACGCGCGG	CRISPRCasFinder

spacers of NZ_CP045178_27

>27.1|7362382|38|NZ_CP045178|CRISPRCasFinder
GACGGTCTCCGACATCGCCGTCACCGCGGACCCGCGCA

CRISPR arrays and Neighbor proteins around NZ_CP045178_27

CRISPR arrays

The CRISPR arrays of NZ_CP045178_27

>merge|NZ_CP045178|27|7362359-7362442|CRISPRCasFinder
GGGTGGAGCCACGGCACGCGCGGGACGGTCTCCGACATCGCCGTCACCGCGGACCCGCGCAGCGTGGAGCCACGGCACGCGCGG

>NZ_CP045178|27|22|7362359-7362442|CRISPRCasFinder
GGGTGGAGCCACGGCACGCGCGG	GACGGTCTCCGACATCGCCGTCACCGCGGACCCGCGCA
GCGTGGAGCCACGGCACGCGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077965800.1|7351309_7351690_-|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077965824.1|7361281_7362085_+|hydrolase	unknown	unknown	gnl|CDD|143604
NZ_CP045178.1|WP_077965966.1|7370484_7371384_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NZ_CP045178.1|WP_077965806.1|7353691_7355329_-|acetolactate-synthase	unknown	unknown	gnl|CDD|236041
NZ_CP045178.1|WP_107502692.1|7358782_7359106_-|hypothetical-protein	unknown	unknown	gnl|CDD|237171
NZ_CP045178.1|WP_107502691.1|7350238_7351030_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238870
NZ_CP045178.1|WP_077965808.1|7355898_7357161_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293841
NZ_CP045178.1|WP_077965829.1|7372922_7374197_+|hypothetical-protein	unknown	unknown	gnl|CDD|377824
NZ_CP045178.1|WP_077965810.1|7357507_7358659_-|S1-family-peptidase	unknown	unknown	gnl|CDD|365866
NZ_CP045178.1|WP_077965827.1|7367771_7368785_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP045178.1|WP_077965825.1|7364024_7365347_-|histidinol-dehydrogenase	unknown	unknown	gnl|CDD|237103
NZ_CP045178.1|WP_077965962.1|7365458_7366217_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|131480
NZ_CP045178.1|WP_077965963.1|7366279_7367410_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380354
NZ_CP045178.1|WP_107502693.1|7359280_7360867_+|MFS-transporter	unknown	unknown	gnl|CDD|340927
NZ_CP045178.1|WP_077965828.1|7371597_7372926_+|histidinol-dehydrogenase	unknown	unknown	gnl|CDD|237103
NZ_CP045178.1|WP_077965804.1|7352465_7353695_-|glutamate-dehydrogenase	unknown	unknown	gnl|CDD|133445
NZ_CP045178.1|WP_107502694.1|7362499_7363246_-|2-dehydro-3-deoxyglucarate-aldolase	unknown	unknown	gnl|CDD|226356
NZ_CP045178.1|WP_077965802.1|7351752_7352373_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379409
NZ_CP045178.1|WP_107502712.1|7363242_7364004_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|212491
NZ_CP045178.1|WP_077965965.1|7369193_7370351_+|FAD-binding-monooxygenase	unknown	unknown	gnl|CDD|236203

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077965827.1|7367771_7368785_+|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.2316e-102
NZ_CP045178.1|WP_077965824.1|7361281_7362085_+|hydrolase	gnl|CDD|143604	cd07580, nitrilase_2, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	3.40608e-95
NZ_CP045178.1|WP_077965966.1|7370484_7371384_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.9794e-33
NZ_CP045178.1|WP_077965806.1|7353691_7355329_-|acetolactate-synthase	gnl|CDD|236041	PRK07524, PRK07524, 5-guanidino-2-oxopentanoate decarboxylase.	2.82671e-157
NZ_CP045178.1|WP_107502692.1|7358782_7359106_-|hypothetical-protein	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.00449423
NZ_CP045178.1|WP_107502691.1|7350238_7351030_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238870	cd01832, SGNH_hydrolase_like_1, Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.	1.58013e-65
NZ_CP045178.1|WP_077965808.1|7355898_7357161_+|MBL-fold-metallo-hydrolase	gnl|CDD|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.79779e-71
NZ_CP045178.1|WP_077965829.1|7372922_7374197_+|hypothetical-protein	gnl|CDD|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	1.09977e-17
NZ_CP045178.1|WP_077965810.1|7357507_7358659_-|S1-family-peptidase	gnl|CDD|365866	pfam00089, Trypsin, Trypsin.	3.42192e-13
NZ_CP045178.1|WP_077965825.1|7364024_7365347_-|histidinol-dehydrogenase	gnl|CDD|237103	PRK12447, PRK12447, histidinol dehydrogenase; Reviewed.	0
NZ_CP045178.1|WP_077965962.1|7365458_7366217_-|alpha/beta-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	2.15899e-11
NZ_CP045178.1|WP_077965963.1|7366279_7367410_-|cupin-domain-containing-protein	gnl|CDD|380354	cd02225, cupin_PA3510-like, Pseudomonas aeruginosa PA3510 and related proteins, cupin domain. This family includes bacterial proteins homologous to PA3510, a Pseudomonas aeruginosa protein of unknown function with a beta-barrel fold that belongs to the cupin superfamily.	1.75915e-18
NZ_CP045178.1|WP_107502693.1|7359280_7360867_+|MFS-transporter	gnl|CDD|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.20543e-115
NZ_CP045178.1|WP_077965828.1|7371597_7372926_+|histidinol-dehydrogenase	gnl|CDD|237103	PRK12447, PRK12447, histidinol dehydrogenase; Reviewed.	5.68899e-173
NZ_CP045178.1|WP_077965804.1|7352465_7353695_-|glutamate-dehydrogenase	gnl|CDD|133445	cd01076, NAD_bind_1_Glu_DH, NAD(P) binding domain of glutamate dehydrogenase, subgroup 1. Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. Glutamate DH is a multidomain enzyme that catalyzes the reaction from glutamate to 2-oxyoglutarate and ammonia in the presence of NAD or NADP. It is present in all organisms. Enzymes involved in ammonia assimilation are typically NADP+-dependent, while those involved in glutamate catabolism are generally NAD+-dependent. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha -beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.	4.35897e-71
NZ_CP045178.1|WP_107502694.1|7362499_7363246_-|2-dehydro-3-deoxyglucarate-aldolase	gnl|CDD|226356	COG3836, HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism].	5.70869e-47
NZ_CP045178.1|WP_077965802.1|7351752_7352373_-|TetR-family-transcriptional-regulator	gnl|CDD|379409	pfam13977, TetR_C_6, BetI-type transcriptional repressor, C-terminal. This family comprises the C-terminal portion of proteins that belong to the TetR family of transcriptional regulators. The C-terminus represents the regulatory region, and does not include the DNA binding helix-turn-helix domain. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. One of the target proteins is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	2.49646e-12
NZ_CP045178.1|WP_107502712.1|7363242_7364004_-|SDR-family-oxidoreductase	gnl|CDD|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.58579e-61
NZ_CP045178.1|WP_077965965.1|7369193_7370351_+|FAD-binding-monooxygenase	gnl|CDD|236203	PRK08255, PRK08255, bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase.	5.36448e-122

Protein sequences

>NZ_CP045178.1|WP_077965824.1|7361281_7362085_+|hydrolase
MTRVVCRPLAPRLGEFEANQRAVLDAIDAARDADILVLPELVTTGYVFHTRAEAADAAIGAEGPELAAWSAALTGDTVVVAGFAERGEDGVIHNSAALVGTDGVRAVHRKAHLWDREKLFFTPGDRPPPVVDTAFGRVAVLICYDLEFPEYTRRAALDGADLLAVPVNWPLVPRPEGERPPEVVIAQAAALVNRVAVACCDRGGTERGQRWTEGTTLIGSDGWVVATATTDDPAGARAELDLLAGRDKRLTDHCDLFGDRRPELYGG
>NZ_CP045178.1|WP_107502693.1|7359280_7360867_+|MFS-transporter
MTERPASRTAGPQRAGIPSSDRPTAARRRARSPPHRAIPPVRHWDDSVPGPRDTARPYPEGGTTMAADPTASGRPAPPPSRTGMPRAVLAGCVGNFIEQIDVGLYGYLAPTMAGAFFPHGNPTVALISTYGTFALGFLVQPLGGVFFGRIGDRVGRRTMLMVTIVLMGVLTACIGVLPTYARIGVASPMLLLFVRILQGMVHGGEYGGALTFIIEYAPRRKRGLYMGYASIGVFGGLLVGAGMSSAVSALLTEDQMADWGWRLPFLVALPLAVGGLLLRSKVGETPAFLELQKSAPAPKESPVLETLRTYWRPLLTFTGYAMTNAVLSYTWVTYLPQWLSDEGGISHSAAFASNLISLAAYLPLLVLAGWLSDRIGRKPMLLAGCVACLTLVPLAFWVAHGGTFGSAILAQLIYLVPEFCIAVPATASLPEMVPTHVRVTATALGFNVPFAVFSGTAPVVATALVNWTGSLYSVWFYLGALAVISFFAVFYGYHESSRGSLSGSEAPTKEAATDSRAAHGDRAEPARN
>NZ_CP045178.1|WP_107502692.1|7358782_7359106_-|hypothetical-protein
MRTARRGQRTAGRGQRTAWRGQRTADSGRAVDRTPSGDLGSRRRGRGPRRRGRRGRRGRLTESARSDREQPGRERTAGTRGNRWGVKGRPGHQRTADTCHAPDINLG
>NZ_CP045178.1|WP_077965810.1|7357507_7358659_-|S1-family-peptidase
MRTGLSTLLLVATWATAGLVPASAADSPQAGSAPRSATAAPASEGLISAMRTDLGLTERQARTRLAAEATARSVEAKAKRAAGASFGGSWFDAKSQRLTVAVTDGGDSAAVRATGAAVKKVAHTARQLDAAKARLDRMSAPAGVSSWHVDPKTNKVVVNVVAEQRDDTRVRRFVADAREAGPVTVEETGGKPRTFAAGTVGGDPYYTGNVRCSIGFSVNGGFVTAGHCGQAGASVSGWDGSAVGSFQGSSFPGNDYAWVSVGNGWWTEPVVLGWGTIPDRLVHGSAVSPVGTSICRSGSTSHWHCGNVLATNETVNYAQGAVYEMTKTSVCAEPGDSGGSFISGDQAQGVTSGGWGNCSTGGETWHQPINEILNRYGLTLRTA
>NZ_CP045178.1|WP_077965808.1|7355898_7357161_+|MBL-fold-metallo-hydrolase
MEDLTESSGGAVTAARSLSHGLRSLRPVAFGADPSGARMNRIRRSPNFDTASGTFRNPAGPDAVSAVSRLEFAKNFFRKEARAGRAPSGVIPVYPTTIADLVQPPDDGLRFTWMGHSSVLTEIDGARVLFDPVWGERCSPFSFAGPKRLHPAPVPLAALGPEPVDAVVISHDHYDHLDLPTIKALARTGTVFAVPLGVGAHLEHWGVPADRVRELDWHESTEVAGLTLTATPARHFCGRGLRNQQHTLWASWSVAGPEHRVYHSGDTGYFPGFQEIGATYGPFDVTMVQIGAYSEFVPAGSPDGKPDPGPWPDIHMTPDEGIRAQLDLQGGQPGGVMLPIHWGTFNLAGHPWHEPAERIMLAAREAGQTIAAPRPGEPFEPSHPSSVYPWWRDVAPVPAGGWPSWPARQTSPRPDVAADR
>NZ_CP045178.1|WP_077965806.1|7353691_7355329_-|acetolactate-synthase
MGGLLTARTATSPAVTGGAAVVRSLAAHGVTQAFGIPGTHNLEIYRHLTAHGIAHLAPRHEQGAGYAADAYARLTGRPGVVITTTGPALLNVAAAVGQAHSDSVPLLVISPGMPLRHPRLQNGLLHEMRSQTEALRQVTAFSHRVSTVEEIGTAVARAFALFGGGRPRPVHIEIPLDLLEAAEPAGPVRLAPALGAAVPEPVALERAAALLRGATHPALILGGGSREAAEACLALAEELDAPVVTSANGKGVVAETHPLSLGVSLHSPAVRKWLSDRDAVLAVGTELAESDLWSAPPPLTGLIRADIDPDQMYSGPAAEVALVGDAVATAGALLTAVRTPAGTEKRRAGAAKEVASVRAARDAETSTRDARWLPYLRVLREVLADDAVLTSDSAQCCYYGALPHLPLGPEGRYLHPTGFGTLGYALPAAIGALSACPDRQVVALSGDGGFQFTSQELATAAQAGLPLPVIVFDNGGYGEIRDGMAARGDTPHAVDLAPLDLPALARAHGGHGAHAADPEEFRAALTTALTTSGPTLITVPEETLR
>NZ_CP045178.1|WP_077965804.1|7352465_7353695_-|glutamate-dehydrogenase
MTTAETAPARATAHEPSPAPPLISLTWTDHVTGRQGFLVVDRLVRGVSSGGLRMRPGCTLPEVTGLARGMTMKEALHYNPEGRYIPLGGAKGGIDCDPRDPEAYGVLVRYLRAMRPHIETFWTMGEDLGLTQDLVDRAAAEAGLVSSIQAVYPLLDDEAAARQRLADAFAVDVDGIGLDELVGGCGVAEAVLAALDRAGVPHTGTRVSVQGLGTMGGATARFLSRAGLLVVAVADIKGTIANPAGLDVEALLAARDGHGAVNRAALRPGDAELPGDAWLSADAEVLVPAAVSYAIDAKGQEAITARWIVEAANMPVLPEAEALLTRRGVVVLPDVVVNSGTNAWWWWVLFGDIAPTAEDSFAYTRASMRALVDLMLARADSEGSTPREAAHAVVADRLPRIAERFGWYR
>NZ_CP045178.1|WP_077965802.1|7351752_7352373_-|TetR-family-transcriptional-regulator
MARVRLSVAQRREELLGAAVEQIQQRGVAALRVADVAAALGVSNALVLYHFATKEKLVAAAFAYAAEADLVHLRKLLGRRTTAVRRLRAAVRWYAPTGTAKGWRLWIEGWAVSLREPALREVARGLDGEWKAALAEVMAQGAAAGEFHCQDPVGAALRLTALLDGFAVQFTAYESTVSRTLMQGWVDDALARELGLDRSALTATAR
>NZ_CP045178.1|WP_077965800.1|7351309_7351690_-|hypothetical-protein
MSRRTTGQAGSTAGQPTGMRPTTRGAVGCLLAGLGATTAALVWAPLAAPSIDGGFEDEARDLSVLYVDLPLVALGGALVPLLAWTLTTRRVHRPWAAALVAAAALALGVWGLVEWWTPRGGHPAPS
>NZ_CP045178.1|WP_107502691.1|7350238_7351030_+|SGNH/GDSL-hydrolase-family-protein
MAQVSRFPSNPVIRSYAAVGDSFTEGVGDPGPGGGYVGWADRLAVLLADRLPEHTFRYANLAVRGKLLDQIVAGQVARAKELAPDLVTFAAGGNDMLRPGADPDDAAERFERAVADLRDSVGTVMVTTGFDTRDTPVLRRLRGKIATYNEHVRAVADRYGCPVLDLWSLKTIQDRRAWDTDRLHLSAEGHTRVALRAGLVLGLEVPADPDQPWPPLPPRGTLEERRDDITWAREYLVPWIGRRLRGESSGDHVVAKRPDLLPL
>NZ_CP045178.1|WP_107502694.1|7362499_7363246_-|2-dehydro-3-deoxyglucarate-aldolase
MSAVSLKERAAGGESLRGVLVRIPAEELIEMAGVAGLDFVLLDCEHGPSDTLELRRHVAAAQVHGMPVLVRVGEHDSRLVLRALDHGAAGVVVPHVDDAATAREAVRAARYPPRGERGFATYGRAGRYGTVSADAHRAAAENTLVFVMAESEEACREAPEILATDGVDGVWVGPADLAVSMAEEAGAPRVREAMAAAHIAAAEAGAFRMDIVGSREAADAAAADGSRFVVHNLTAELMRLLGGLAARD
>NZ_CP045178.1|WP_107502712.1|7363242_7364004_-|SDR-family-oxidoreductase
MGRLAGRTALVTGGGSGLGAVLAHALADAGARVVAVGRTLDALERTARARPGSVRAARCDVTDPASVDALAGALAAERVDILVNNAGVPGPVAPLTAIEPDDWDEVFSVNVRGVYLMCRAFLPGMTERGEGDVLNIASVSGKRPLAGRTPYCASKAAVLGLTSALAAEAGPLGVRVNSLSPGPVDSERMRRNFRLEAERTGVSYEEAERAFVSRALLERMVTEEEVAAAAVAMIGMSGLCAADLDLSAGMVAR
>NZ_CP045178.1|WP_077965825.1|7364024_7365347_-|histidinol-dehydrogenase
MSWNLKSPSAAVPAPQGDSTVAERVAGIIDDVRTRGDAAVRHWSATFDSWEPESFRLSPERIEEIVAGVPQQVLDDIRFVQEQVRVFARAQRDSLTDIEVETLPGVRLGHRHLPVGRVGAYVPGGRYPLTASAHMTIVTAKVAGVPSVAACTPPIRGEVPAATVAAMHLAGADEIHLLGGVQAVAALAVGTETIDRVDLLAGPGNAYVAEAKRRLYGEVGIDLFAGPTEILVIADGTTDPFVAAVDLLSQAEHGPDSPAVLVTTSEETGRAVLGHVERLLPTMPTKDFAGPAWRDHGEIVVVDSVEEAFAVADGYASEHVQVLTEQPRLALDHMRDYGALFLGEGTCVSYGDKVIGTNHVLPTKGAARYTGGLWVGKYLKTVTYQEVTDEASSARLGEVCGRAARVELFEGHARSGDVRAAKYAGAELPWNETAPSGAAS
>NZ_CP045178.1|WP_077965962.1|7365458_7366217_-|alpha/beta-hydrolase
MLCDAALWDGVREALPGPAVDTVIDASTIGAMAEQVLGAVEGPFVLVGLSLGAIVGFEVCRRAPERVAGLAVLSANASAPRPEQYAAWRAADLAAASGDFDAHVEASVLPGMFRSPEPGPREADAFRAMARRVGPSRYRSQLAAQATREDAFPALSGYGGPVLALCGALDRVTPPEFHAAVADAARRPTLRVLPGAGHLLPLEDPVEVARELRGWLAESGADFGADADADADARADADARPRTEARTEAVSG
>NZ_CP045178.1|WP_077965963.1|7366279_7367410_-|cupin-domain-containing-protein
MERRRTDAAEVARRTVRSADFVSCDQAFIDCRTPGSDRKENYSMIGRGVSQSAGQVVNLEEPHGFNVGAAAMPNGVVNNLHLHFTAEVFLCFRGEYTLRWGVDGEEGELVLREGDIASVPTWIFRGFTNTGPDDGWLFTTLGMNDTGGIIWGPSVLKEAAGHGLYLSADNELLDTVADGALGDDVELITPIADHHIAALRHYSPAEMRRRIAAHDELAWSSKALLDHALPGGGARLALVIGFGMTEDRDQEPVVFNPHGHNIAWLRAEAERGVLRHRTDHNQVLMVKDGEWEVTLDDGEPVTVRLGHRDLLSVPAGTWRTLRNVSGGDATMVVVNDGDGRVLLEWDEEVVKAAADAGVGVDHNGYLAPYDLIPRRR
>NZ_CP045178.1|WP_077965827.1|7367771_7368785_+|LacI-family-transcriptional-regulator
MTITSRDVARLAGVSQPTVSRALRGDARVSAATRERVTRAADALGYVPSEAGRSLVTRRTRRIGTVVTDLANPFYPHLVGPLHDELERHGYRMMMFAERSDSKVATERLLDGSLDGVVLMTSKIDSMLPAELTRRGLPYVFLNRESGDGRGDAAVVDNHLGGRLAADLVAGLGHRHIGGIFGPQDTTTGRERELGFRLALAEHGLAVQAGAVRHGPFDFAAGHALLAEVLAATPRPTAVFCGSDAIAIGALNAALGAGLRVPEDLTVIGFDDIPMASWEAFRLTTVSHDLVEMAAGAARLLIGRIETEEARDEGEGPRRVVSVPRLVERGTHAGPPR
>NZ_CP045178.1|WP_077965965.1|7369193_7370351_+|FAD-binding-monooxygenase
MKRQDPSHDITVHERNPRGSTYGWGVTCWRGLIDKLHENDPETALAIGAGAARWDRGTAYVRDDVTVREGDEALGIGRHNLLAVLAERAESLGVRLEFGREITDESAVPGADLIVAADGVNSALRETHADHFGSRIRVGDNKYIWLGTDKPFASFTFAFVESAHGWIWCYGYPFSEDRATFLVECSPRTWAGLGLDRASETDTLALLERLFAGPLDGYRLIGRAQPGVAAPWLNFRTLTNRTWSRGNLVLLGDAAHTTHYSIGAGTTLALEDAIALAGALRPGDGTAPALARYERERRSAILPMQSAARYSAQWFENLPRYMGLAPEEMFALLGQRHSPLLPYVPPQLYYRIDRTAEQSEALRRLKRWLGPRVAGTLHARSRSSA
>NZ_CP045178.1|WP_077965966.1|7370484_7371384_-|LysR-family-transcriptional-regulator
MTLKQLRSFVAAARLGSFTAAAASMDVAQASVSELIRKVEDEEGVALFVRGARRLLLTSAGSTLLPFAERALAAVDEGAHALRALRSLQGGVVTFGLLRNAAFYVLSDLVQHFHVNHPNVRVRLVGLNSVEVAEEVAAGTVEAGLVVLPVEDAALKVTPLLRDEVLYVSGDPARAARPVTVADLAQARLVLYDAHYGWRDPTRRQLAERSQLAGVRIEPWVEVEHVEPALELVARGVGDTVVSRAVAKSPSFPAGLHTVGFEEPMYDTIALVHRQGTELSPAAREMARLARRMLLRRQG
>NZ_CP045178.1|WP_077965828.1|7371597_7372926_+|histidinol-dehydrogenase
MRFNPSRLAEFDGSYRFLKPPSDSPAAQRDPAVATRVSEMLSAIERGGMDAVLKYARELDGWQRPEVEIGAAELARTGDGLPEDVRAALELGHERTSDFARRQRAHLVDFEAELAPGLIAGQRYVPVQRVGAYLPAGRFPLLAGAFMTVGVAKAAGVPSVLACTPPGREGNADPAVLYGAHLSGADRAYVLGGVQALAAMAFGLLGEYPVDMLVGAGNAYVAEAKRQLFGKVAIDLPAGPSEVAVLADDTADARLVAADLLGQAEHGTESPAALITTSPRLGEAVVAEVDRQLETLATRDVAGPAWRDHGSVTWAKDAATAIALMDELAPEHLEIQTADDEMYLAGLHNYGSVFLGPWSTVAYSDKGMAGTNHVLPTAGGAKHSAGLSVSRFLKPLTYQRVSRAGTEQLAGAVESISAYEGMAAHGATATLRRQALREGDQS
>NZ_CP045178.1|WP_077965829.1|7372922_7374197_+|hypothetical-protein
MSRTENGDAPVDRRQPATTPATTDEAGPAKAAAPAQDHPARAGHPATGPADRAARRHMPSDYGIALRPGNGADLPGRLPGERRQPMRGFEDQYTDIVDYIVRITHRIWEDQDVGYIYDTYAPGCRLHDDSGLKVGVEPLVTGTMANIHAFPDCRHYADEVIWAGDDSDGFVTSHRAQNIGTHTGDWQWGPATGKPLRTWVMANCEVVENEITEEWVLYNTASKLAQLGIDVREAARAFGNEAGPAALGDQRLGDVERLVGGRKPLPYPKPGRGPAGADGLDVDHFVRALFHDVYNRRDLSAIDRAYTPGVRWYGTSDRTGYGRSDVRGMARALLATFPDLGVKVDEVYWMGNDADGYRVSVRWSGAGTHRGHALYGRPTGRRVHLWGLSQLYMSQGMITEDWALFNEFDVLAQLLRDDPPNLPG

Crispr_ID: NZ_CP045178_28

• CRISPR_ID: NZ_CP045178_28
• CRISPR_location: 7367413-7367510
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of NZ_CP045178_28

Consensus_repeat	Method
GCCCGGGTGCGGTACTCGCGGCG	CRISPRCasFinder

spacers of NZ_CP045178_28

>28.1|7367436|52|NZ_CP045178|CRISPRCasFinder
GCGGTACGCCCGGGTTCCGCGCCCCCGGGGACCGTCGTCGCGGGTGTCGTAC

CRISPR arrays and Neighbor proteins around NZ_CP045178_28

CRISPR arrays

The CRISPR arrays of NZ_CP045178_28

>merge|NZ_CP045178|28|7367413-7367510|CRISPRCasFinder
GCCCGGGTGCGGTACTCGCGGCGGCGGTACGCCCGGGTTCCGCGCCCCCGGGGACCGTCGTCGCGGGTGTCGTACGCCCGGGTGCGGTACTCGCGGGC

>NZ_CP045178|28|23|7367413-7367510|CRISPRCasFinder
GCCCGGGTGCGGTACTCGCGGCG	GCGGTACGCCCGGGTTCCGCGCCCCCGGGGACCGTCGTCGCGGGTGTCGTAC
GCCCGGGTGCGGTACTCGCGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077965965.1|7369193_7370351_+|FAD-binding-monooxygenase	unknown	unknown	gnl|CDD|236203
NZ_CP045178.1|WP_077965824.1|7361281_7362085_+|hydrolase	unknown	unknown	gnl|CDD|143604
NZ_CP045178.1|WP_077965966.1|7370484_7371384_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
NZ_CP045178.1|WP_107502692.1|7358782_7359106_-|hypothetical-protein	unknown	unknown	gnl|CDD|237171
NZ_CP045178.1|WP_077965962.1|7365458_7366217_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|131480
NZ_CP045178.1|WP_077965808.1|7355898_7357161_+|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293841
NZ_CP045178.1|WP_077965829.1|7372922_7374197_+|hypothetical-protein	unknown	unknown	gnl|CDD|377824
NZ_CP045178.1|WP_077965810.1|7357507_7358659_-|S1-family-peptidase	unknown	unknown	gnl|CDD|365866
NZ_CP045178.1|WP_077965833.1|7378452_7379010_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|376570
NZ_CP045178.1|WP_077965825.1|7364024_7365347_-|histidinol-dehydrogenase	unknown	unknown	gnl|CDD|237103
NZ_CP045178.1|WP_077965963.1|7366279_7367410_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380354
NZ_CP045178.1|WP_077965830.1|7377076_7377511_+|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl|CDD|367422
NZ_CP045178.1|WP_107502693.1|7359280_7360867_+|MFS-transporter	unknown	unknown	gnl|CDD|340927
NZ_CP045178.1|WP_077965828.1|7371597_7372926_+|histidinol-dehydrogenase	unknown	unknown	gnl|CDD|237103
NZ_CP045178.1|WP_077965827.1|7367771_7368785_+|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
NZ_CP045178.1|WP_107502694.1|7362499_7363246_-|2-dehydro-3-deoxyglucarate-aldolase	unknown	unknown	gnl|CDD|226356
NZ_CP045178.1|WP_077965834.1|7379200_7380163_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|378820
NZ_CP045178.1|WP_107502712.1|7363242_7364004_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|212491
NZ_CP045178.1|WP_077965832.1|7377862_7378456_+|ATP/GTP-binding-protein	unknown	unknown	gnl|CDD|225138
NZ_CP045178.1|WP_077965831.1|7377513_7377885_+|DUF742-domain-containing-protein	unknown	unknown	gnl|CDD|283084

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077965965.1|7369193_7370351_+|FAD-binding-monooxygenase	gnl|CDD|236203	PRK08255, PRK08255, bifunctional salicylyl-CoA 5-hydroxylase/oxidoreductase.	5.36448e-122
NZ_CP045178.1|WP_077965824.1|7361281_7362085_+|hydrolase	gnl|CDD|143604	cd07580, nitrilase_2, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	3.40608e-95
NZ_CP045178.1|WP_077965966.1|7370484_7371384_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.9794e-33
NZ_CP045178.1|WP_107502692.1|7358782_7359106_-|hypothetical-protein	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	0.00449423
NZ_CP045178.1|WP_077965962.1|7365458_7366217_-|alpha/beta-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	2.15899e-11
NZ_CP045178.1|WP_077965808.1|7355898_7357161_+|MBL-fold-metallo-hydrolase	gnl|CDD|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.79779e-71
NZ_CP045178.1|WP_077965829.1|7372922_7374197_+|hypothetical-protein	gnl|CDD|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	1.09977e-17
NZ_CP045178.1|WP_077965810.1|7357507_7358659_-|S1-family-peptidase	gnl|CDD|365866	pfam00089, Trypsin, Trypsin.	3.42192e-13
NZ_CP045178.1|WP_077965833.1|7378452_7379010_+|GAF-domain-containing-protein	gnl|CDD|376570	pfam01590, GAF, GAF domain. This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	6.33791e-09
NZ_CP045178.1|WP_077965825.1|7364024_7365347_-|histidinol-dehydrogenase	gnl|CDD|237103	PRK12447, PRK12447, histidinol dehydrogenase; Reviewed.	0
NZ_CP045178.1|WP_077965963.1|7366279_7367410_-|cupin-domain-containing-protein	gnl|CDD|380354	cd02225, cupin_PA3510-like, Pseudomonas aeruginosa PA3510 and related proteins, cupin domain. This family includes bacterial proteins homologous to PA3510, a Pseudomonas aeruginosa protein of unknown function with a beta-barrel fold that belongs to the cupin superfamily.	1.75915e-18
NZ_CP045178.1|WP_077965830.1|7377076_7377511_+|roadblock/LC7-domain-containing-protein	gnl|CDD|367422	pfam03259, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	1.39376e-23
NZ_CP045178.1|WP_107502693.1|7359280_7360867_+|MFS-transporter	gnl|CDD|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.20543e-115
NZ_CP045178.1|WP_077965828.1|7371597_7372926_+|histidinol-dehydrogenase	gnl|CDD|237103	PRK12447, PRK12447, histidinol dehydrogenase; Reviewed.	5.68899e-173
NZ_CP045178.1|WP_077965827.1|7367771_7368785_+|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	3.2316e-102
NZ_CP045178.1|WP_107502694.1|7362499_7363246_-|2-dehydro-3-deoxyglucarate-aldolase	gnl|CDD|226356	COG3836, HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism].	5.70869e-47
NZ_CP045178.1|WP_077965834.1|7379200_7380163_+|alpha/beta-hydrolase	gnl|CDD|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	6.47662e-52
NZ_CP045178.1|WP_107502712.1|7363242_7364004_-|SDR-family-oxidoreductase	gnl|CDD|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.58579e-61
NZ_CP045178.1|WP_077965832.1|7377862_7378456_+|ATP/GTP-binding-protein	gnl|CDD|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	9.67387e-47
NZ_CP045178.1|WP_077965831.1|7377513_7377885_+|DUF742-domain-containing-protein	gnl|CDD|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	1.25138e-32

Protein sequences

>NZ_CP045178.1|WP_077965963.1|7366279_7367410_-|cupin-domain-containing-protein
MERRRTDAAEVARRTVRSADFVSCDQAFIDCRTPGSDRKENYSMIGRGVSQSAGQVVNLEEPHGFNVGAAAMPNGVVNNLHLHFTAEVFLCFRGEYTLRWGVDGEEGELVLREGDIASVPTWIFRGFTNTGPDDGWLFTTLGMNDTGGIIWGPSVLKEAAGHGLYLSADNELLDTVADGALGDDVELITPIADHHIAALRHYSPAEMRRRIAAHDELAWSSKALLDHALPGGGARLALVIGFGMTEDRDQEPVVFNPHGHNIAWLRAEAERGVLRHRTDHNQVLMVKDGEWEVTLDDGEPVTVRLGHRDLLSVPAGTWRTLRNVSGGDATMVVVNDGDGRVLLEWDEEVVKAAADAGVGVDHNGYLAPYDLIPRRR
>NZ_CP045178.1|WP_077965962.1|7365458_7366217_-|alpha/beta-hydrolase
MLCDAALWDGVREALPGPAVDTVIDASTIGAMAEQVLGAVEGPFVLVGLSLGAIVGFEVCRRAPERVAGLAVLSANASAPRPEQYAAWRAADLAAASGDFDAHVEASVLPGMFRSPEPGPREADAFRAMARRVGPSRYRSQLAAQATREDAFPALSGYGGPVLALCGALDRVTPPEFHAAVADAARRPTLRVLPGAGHLLPLEDPVEVARELRGWLAESGADFGADADADADARADADARPRTEARTEAVSG
>NZ_CP045178.1|WP_077965825.1|7364024_7365347_-|histidinol-dehydrogenase
MSWNLKSPSAAVPAPQGDSTVAERVAGIIDDVRTRGDAAVRHWSATFDSWEPESFRLSPERIEEIVAGVPQQVLDDIRFVQEQVRVFARAQRDSLTDIEVETLPGVRLGHRHLPVGRVGAYVPGGRYPLTASAHMTIVTAKVAGVPSVAACTPPIRGEVPAATVAAMHLAGADEIHLLGGVQAVAALAVGTETIDRVDLLAGPGNAYVAEAKRRLYGEVGIDLFAGPTEILVIADGTTDPFVAAVDLLSQAEHGPDSPAVLVTTSEETGRAVLGHVERLLPTMPTKDFAGPAWRDHGEIVVVDSVEEAFAVADGYASEHVQVLTEQPRLALDHMRDYGALFLGEGTCVSYGDKVIGTNHVLPTKGAARYTGGLWVGKYLKTVTYQEVTDEASSARLGEVCGRAARVELFEGHARSGDVRAAKYAGAELPWNETAPSGAAS
>NZ_CP045178.1|WP_107502712.1|7363242_7364004_-|SDR-family-oxidoreductase
MGRLAGRTALVTGGGSGLGAVLAHALADAGARVVAVGRTLDALERTARARPGSVRAARCDVTDPASVDALAGALAAERVDILVNNAGVPGPVAPLTAIEPDDWDEVFSVNVRGVYLMCRAFLPGMTERGEGDVLNIASVSGKRPLAGRTPYCASKAAVLGLTSALAAEAGPLGVRVNSLSPGPVDSERMRRNFRLEAERTGVSYEEAERAFVSRALLERMVTEEEVAAAAVAMIGMSGLCAADLDLSAGMVAR
>NZ_CP045178.1|WP_107502694.1|7362499_7363246_-|2-dehydro-3-deoxyglucarate-aldolase
MSAVSLKERAAGGESLRGVLVRIPAEELIEMAGVAGLDFVLLDCEHGPSDTLELRRHVAAAQVHGMPVLVRVGEHDSRLVLRALDHGAAGVVVPHVDDAATAREAVRAARYPPRGERGFATYGRAGRYGTVSADAHRAAAENTLVFVMAESEEACREAPEILATDGVDGVWVGPADLAVSMAEEAGAPRVREAMAAAHIAAAEAGAFRMDIVGSREAADAAAADGSRFVVHNLTAELMRLLGGLAARD
>NZ_CP045178.1|WP_077965824.1|7361281_7362085_+|hydrolase
MTRVVCRPLAPRLGEFEANQRAVLDAIDAARDADILVLPELVTTGYVFHTRAEAADAAIGAEGPELAAWSAALTGDTVVVAGFAERGEDGVIHNSAALVGTDGVRAVHRKAHLWDREKLFFTPGDRPPPVVDTAFGRVAVLICYDLEFPEYTRRAALDGADLLAVPVNWPLVPRPEGERPPEVVIAQAAALVNRVAVACCDRGGTERGQRWTEGTTLIGSDGWVVATATTDDPAGARAELDLLAGRDKRLTDHCDLFGDRRPELYGG
>NZ_CP045178.1|WP_107502693.1|7359280_7360867_+|MFS-transporter
MTERPASRTAGPQRAGIPSSDRPTAARRRARSPPHRAIPPVRHWDDSVPGPRDTARPYPEGGTTMAADPTASGRPAPPPSRTGMPRAVLAGCVGNFIEQIDVGLYGYLAPTMAGAFFPHGNPTVALISTYGTFALGFLVQPLGGVFFGRIGDRVGRRTMLMVTIVLMGVLTACIGVLPTYARIGVASPMLLLFVRILQGMVHGGEYGGALTFIIEYAPRRKRGLYMGYASIGVFGGLLVGAGMSSAVSALLTEDQMADWGWRLPFLVALPLAVGGLLLRSKVGETPAFLELQKSAPAPKESPVLETLRTYWRPLLTFTGYAMTNAVLSYTWVTYLPQWLSDEGGISHSAAFASNLISLAAYLPLLVLAGWLSDRIGRKPMLLAGCVACLTLVPLAFWVAHGGTFGSAILAQLIYLVPEFCIAVPATASLPEMVPTHVRVTATALGFNVPFAVFSGTAPVVATALVNWTGSLYSVWFYLGALAVISFFAVFYGYHESSRGSLSGSEAPTKEAATDSRAAHGDRAEPARN
>NZ_CP045178.1|WP_107502692.1|7358782_7359106_-|hypothetical-protein
MRTARRGQRTAGRGQRTAWRGQRTADSGRAVDRTPSGDLGSRRRGRGPRRRGRRGRRGRLTESARSDREQPGRERTAGTRGNRWGVKGRPGHQRTADTCHAPDINLG
>NZ_CP045178.1|WP_077965810.1|7357507_7358659_-|S1-family-peptidase
MRTGLSTLLLVATWATAGLVPASAADSPQAGSAPRSATAAPASEGLISAMRTDLGLTERQARTRLAAEATARSVEAKAKRAAGASFGGSWFDAKSQRLTVAVTDGGDSAAVRATGAAVKKVAHTARQLDAAKARLDRMSAPAGVSSWHVDPKTNKVVVNVVAEQRDDTRVRRFVADAREAGPVTVEETGGKPRTFAAGTVGGDPYYTGNVRCSIGFSVNGGFVTAGHCGQAGASVSGWDGSAVGSFQGSSFPGNDYAWVSVGNGWWTEPVVLGWGTIPDRLVHGSAVSPVGTSICRSGSTSHWHCGNVLATNETVNYAQGAVYEMTKTSVCAEPGDSGGSFISGDQAQGVTSGGWGNCSTGGETWHQPINEILNRYGLTLRTA
>NZ_CP045178.1|WP_077965808.1|7355898_7357161_+|MBL-fold-metallo-hydrolase
MEDLTESSGGAVTAARSLSHGLRSLRPVAFGADPSGARMNRIRRSPNFDTASGTFRNPAGPDAVSAVSRLEFAKNFFRKEARAGRAPSGVIPVYPTTIADLVQPPDDGLRFTWMGHSSVLTEIDGARVLFDPVWGERCSPFSFAGPKRLHPAPVPLAALGPEPVDAVVISHDHYDHLDLPTIKALARTGTVFAVPLGVGAHLEHWGVPADRVRELDWHESTEVAGLTLTATPARHFCGRGLRNQQHTLWASWSVAGPEHRVYHSGDTGYFPGFQEIGATYGPFDVTMVQIGAYSEFVPAGSPDGKPDPGPWPDIHMTPDEGIRAQLDLQGGQPGGVMLPIHWGTFNLAGHPWHEPAERIMLAAREAGQTIAAPRPGEPFEPSHPSSVYPWWRDVAPVPAGGWPSWPARQTSPRPDVAADR
>NZ_CP045178.1|WP_077965827.1|7367771_7368785_+|LacI-family-transcriptional-regulator
MTITSRDVARLAGVSQPTVSRALRGDARVSAATRERVTRAADALGYVPSEAGRSLVTRRTRRIGTVVTDLANPFYPHLVGPLHDELERHGYRMMMFAERSDSKVATERLLDGSLDGVVLMTSKIDSMLPAELTRRGLPYVFLNRESGDGRGDAAVVDNHLGGRLAADLVAGLGHRHIGGIFGPQDTTTGRERELGFRLALAEHGLAVQAGAVRHGPFDFAAGHALLAEVLAATPRPTAVFCGSDAIAIGALNAALGAGLRVPEDLTVIGFDDIPMASWEAFRLTTVSHDLVEMAAGAARLLIGRIETEEARDEGEGPRRVVSVPRLVERGTHAGPPR
>NZ_CP045178.1|WP_077965965.1|7369193_7370351_+|FAD-binding-monooxygenase
MKRQDPSHDITVHERNPRGSTYGWGVTCWRGLIDKLHENDPETALAIGAGAARWDRGTAYVRDDVTVREGDEALGIGRHNLLAVLAERAESLGVRLEFGREITDESAVPGADLIVAADGVNSALRETHADHFGSRIRVGDNKYIWLGTDKPFASFTFAFVESAHGWIWCYGYPFSEDRATFLVECSPRTWAGLGLDRASETDTLALLERLFAGPLDGYRLIGRAQPGVAAPWLNFRTLTNRTWSRGNLVLLGDAAHTTHYSIGAGTTLALEDAIALAGALRPGDGTAPALARYERERRSAILPMQSAARYSAQWFENLPRYMGLAPEEMFALLGQRHSPLLPYVPPQLYYRIDRTAEQSEALRRLKRWLGPRVAGTLHARSRSSA
>NZ_CP045178.1|WP_077965966.1|7370484_7371384_-|LysR-family-transcriptional-regulator
MTLKQLRSFVAAARLGSFTAAAASMDVAQASVSELIRKVEDEEGVALFVRGARRLLLTSAGSTLLPFAERALAAVDEGAHALRALRSLQGGVVTFGLLRNAAFYVLSDLVQHFHVNHPNVRVRLVGLNSVEVAEEVAAGTVEAGLVVLPVEDAALKVTPLLRDEVLYVSGDPARAARPVTVADLAQARLVLYDAHYGWRDPTRRQLAERSQLAGVRIEPWVEVEHVEPALELVARGVGDTVVSRAVAKSPSFPAGLHTVGFEEPMYDTIALVHRQGTELSPAAREMARLARRMLLRRQG
>NZ_CP045178.1|WP_077965828.1|7371597_7372926_+|histidinol-dehydrogenase
MRFNPSRLAEFDGSYRFLKPPSDSPAAQRDPAVATRVSEMLSAIERGGMDAVLKYARELDGWQRPEVEIGAAELARTGDGLPEDVRAALELGHERTSDFARRQRAHLVDFEAELAPGLIAGQRYVPVQRVGAYLPAGRFPLLAGAFMTVGVAKAAGVPSVLACTPPGREGNADPAVLYGAHLSGADRAYVLGGVQALAAMAFGLLGEYPVDMLVGAGNAYVAEAKRQLFGKVAIDLPAGPSEVAVLADDTADARLVAADLLGQAEHGTESPAALITTSPRLGEAVVAEVDRQLETLATRDVAGPAWRDHGSVTWAKDAATAIALMDELAPEHLEIQTADDEMYLAGLHNYGSVFLGPWSTVAYSDKGMAGTNHVLPTAGGAKHSAGLSVSRFLKPLTYQRVSRAGTEQLAGAVESISAYEGMAAHGATATLRRQALREGDQS
>NZ_CP045178.1|WP_077965829.1|7372922_7374197_+|hypothetical-protein
MSRTENGDAPVDRRQPATTPATTDEAGPAKAAAPAQDHPARAGHPATGPADRAARRHMPSDYGIALRPGNGADLPGRLPGERRQPMRGFEDQYTDIVDYIVRITHRIWEDQDVGYIYDTYAPGCRLHDDSGLKVGVEPLVTGTMANIHAFPDCRHYADEVIWAGDDSDGFVTSHRAQNIGTHTGDWQWGPATGKPLRTWVMANCEVVENEITEEWVLYNTASKLAQLGIDVREAARAFGNEAGPAALGDQRLGDVERLVGGRKPLPYPKPGRGPAGADGLDVDHFVRALFHDVYNRRDLSAIDRAYTPGVRWYGTSDRTGYGRSDVRGMARALLATFPDLGVKVDEVYWMGNDADGYRVSVRWSGAGTHRGHALYGRPTGRRVHLWGLSQLYMSQGMITEDWALFNEFDVLAQLLRDDPPNLPG
>NZ_CP045178.1|WP_077965830.1|7377076_7377511_+|roadblock/LC7-domain-containing-protein
MASDVPTGHVSDLDWLLSGLVQRVPHSRSAVLLSADGLVKSVHGLDTDSADHMAALASGIYSLGRSAGVRFGDGGEVRQVVVELDSTLLFVSAAGSGTCLAVLASREADAAVLGYEMAMLVKSVRPYLSTPARRPAGQPSAMRR
>NZ_CP045178.1|WP_077965831.1|7377513_7377885_+|DUF742-domain-containing-protein
MTAPQDGPWLDDAAGRLVRPYTVSGGRTRPTARFDLLSQVMVTGKPAPPHLGPEHGQALALCGVPASVAEVAAQLRLPAVVTKVLLSDLVDCGALIEKPPDSYHNPTDRSLLEAVLDGLRRRL
>NZ_CP045178.1|WP_077965832.1|7377862_7378456_+|ATP/GTP-binding-protein
MDYDDDSDTFPTALKILIAGGFGVGKTTFVGAVSEIAPLSTEELLTTVSVATDSLEGVENKSTTTVAMDFGRITLDGDHVLYLFGTPGQERFWFMWDELSEGALGAVILADTRRLQDCFAAVDFFEQRGLNFVVAINEFDGAHRYDPGEVRSAMDLGPGVPVVRCDARISSSGVQTLLTLVKHLLSASPAPSYGART
>NZ_CP045178.1|WP_077965833.1|7378452_7379010_+|GAF-domain-containing-protein
MTSTADGHLLLTPADKEAPARVRRLRDLGLGERPDAWLDGFAARLARITGAPCAMVNFIDENRQFFAGLHAPALPAHSGDAATPLLGRYLPRDHGYCPHVVVRRRALVLEDVRDFPRFAGNPVVDDIGIRSYLGAPLIDRTGIALGTVCVVDTAPRAWGKEGLTTIKNLAGELIDDIHRHEAGSL
>NZ_CP045178.1|WP_077965834.1|7379200_7380163_+|alpha/beta-hydrolase
MTSQAPETAYTPGILQAGDGTAVATYTWLPASGRPRAFLQIAHGAAEHALRYDRFARHLVARGYGVVASDHRGHGATAQSTGGLGVTGEGDAEAPDSWRAVVEDLKAVGDQLRALNPGTPVLLLGHSLGSLLARDYAQEYADDLAGLILTGTFRSLPGADREGAQARLEQEVADHGRAAVSSFMPDLFASFNDPFTRRTGFEWLSRDETEVDAYAADERCGFPFSAGLSLDFVRAVRKINDPRNLARVPADLPVHVASGTEDPCNQRMTLVHELLEDFRYIGTDDLTWKGYEGARHEILNETNRDEVQDDLTAWLDKHVL

Crispr_ID: NZ_CP045178_29

• CRISPR_ID: NZ_CP045178_29
• CRISPR_location: 8355729-8356072
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of NZ_CP045178_29

Consensus_repeat	Method
GAGCTGCGCGANGAGCAGAA	CRT

spacers of NZ_CP045178_29

>29.1|8355749|34|NZ_CP045178|CRT
CCAGCAGCGGGAGGAGGACAAGAAATACCAGGAG
>29.2|8355803|34|NZ_CP045178|CRT
ACAGCAGCGTGAGGAGGACAAGAAATATCAGGAC
>29.3|8355857|34|NZ_CP045178|CRT
GGCCGAACAGGAAGAGGCCAAGAAACAGGCGGAC
>29.4|8355911|34|NZ_CP045178|CRT
CCGGCAGCGGGAGGAGGACAAGAAATACCAGGAG
>29.5|8355965|34|NZ_CP045178|CRT
GGGTGAACAGGACGAGGCGAAGAAACTCCAGGAG
>29.6|8356019|34|NZ_CP045178|CRT
CCAGCAGCGGGACGAGGACCGCAAGTACCAGGAC

CRISPR arrays and Neighbor proteins around NZ_CP045178_29

CRISPR arrays

The CRISPR arrays of NZ_CP045178_29

>merge|NZ_CP045178|29|8355729-8356072|CRT
CAACTCCGTGACGAGCAGAACCAGCAGCGGGAGGAGGACAAGAAATACCAGGAGGAGCTGCGCGAGGAGCAGAGACAGCAGCGTGAGGAGGACAAGAAATATCAGGACGAGCTGCGCGCGGAGCAGAAGGCCGAACAGGAAGAGGCCAAGAAACAGGCGGACGAGCTGCGCGAGGAGCAGAACCGGCAGCGGGAGGAGGACAAGAAATACCAGGAGGAGCTGCGCGACGAGCAGAAGGGTGAACAGGACGAGGCGAAGAAACTCCAGGAGGATCTGCGCGAGGAGCAGAACCAGCAGCGGGACGAGGACCGCAAGTACCAGGACGAGCTGCGCGACGAGCAGAA

>NZ_CP045178|29|6|8355729-8356072|CRT
CAACTCCGTGACGAGCAGAA	CCAGCAGCGGGAGGAGGACAAGAAATACCAGGAG
GAGCTGCGCGAGGAGCAGAG	ACAGCAGCGTGAGGAGGACAAGAAATATCAGGAC
GAGCTGCGCGCGGAGCAGAA	GGCCGAACAGGAAGAGGCCAAGAAACAGGCGGAC
GAGCTGCGCGAGGAGCAGAA	CCGGCAGCGGGAGGAGGACAAGAAATACCAGGAG
GAGCTGCGCGACGAGCAGAA	GGGTGAACAGGACGAGGCGAAGAAACTCCAGGAG
GATCTGCGCGAGGAGCAGAA	CCAGCAGCGGGACGAGGACCGCAAGTACCAGGAC
GAGCTGCGCGACGAGCAGAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045178.1|WP_077969128.1|8340131_8343431_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|163057
NZ_CP045178.1|WP_077969133.1|8352947_8353283_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969154.1|8339077_8339935_+|type-VII-secretion-system-associated-protein	unknown	unknown	gnl|CDD|237057
NZ_CP045178.1|WP_077969127.1|8337576_8338551_-|mannose-binding-protein	unknown	unknown	gnl|CDD|214519
NZ_CP045178.1|WP_077967683.1|8396495_8397347_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NZ_CP045178.1|WP_077967677.1|8387332_8389930_-|phosphoenolpyruvate-synthase	unknown	unknown	gnl|CDD|235751
NZ_CP045178.1|WP_077967956.1|8395724_8396129_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
NZ_CP045178.1|WP_143621232.1|8359340_8385548_+|lonely-Cys-domain-containing-protein	unknown	unknown	gnl|CDD|380151
NZ_CP045178.1|WP_077967676.1|8385956_8387165_+|acetylhydrolase	unknown	unknown	gnl|CDD|335313
NZ_CP045178.1|WP_077967678.1|8390721_8390964_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_152330856.1|8344966_8348974_-|type-VII-secretion-protein-EccCa	unknown	unknown	gnl|CDD|274858
NZ_CP045178.1|WP_077969135.1|8353809_8354277_+|type-VII-secretion-system-associated-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077967681.1|8394307_8395498_-|fumarylacetoacetase	unknown	unknown	gnl|CDD|215461
NZ_CP045178.1|WP_077969129.1|8343427_8344672_+|S8-family-serine-peptidase	unknown	unknown	gnl|CDD|274856
NZ_CP045178.1|WP_077969132.1|8350883_8352470_+|type-VII-secretion-protein-EccB	unknown	unknown	gnl|CDD|368288
NZ_CP045178.1|WP_077967674.1|8358887_8359259_+|hypothetical-protein	unknown	unknown	unknown
NZ_CP045178.1|WP_077969131.1|8349431_8350838_+|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl|CDD|274855
NZ_CP045178.1|WP_077967680.1|8391107_8393423_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	unknown	unknown	gnl|CDD|235367
NZ_CP045178.1|WP_077969134.1|8353374_8353683_+|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
NZ_CP045178.1|WP_077967673.1|8358429_8358885_+|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl|CDD|376829

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NZ_CP045178.1|WP_077969128.1|8340131_8343431_+|AAA-family-ATPase	gnl|CDD|163057	TIGR02881, Stage_V_sporulation_protein_K, stage V sporulation protein K. Members of this protein family are the stage V sporulation protein K (SpoVK), a close homolog of the Rubisco expression protein CbbX (TIGR02880) and a members of the ATPase family associated with various cellular activities (pfam00004). Members are strictly limited to bacterial endospore-forming species, but are not universal in this group and are missing from the Clostridium group. [Cellular processes, Sporulation and germination].	6.35577e-83
NZ_CP045178.1|WP_077969154.1|8339077_8339935_+|type-VII-secretion-system-associated-protein	gnl|CDD|237057	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau.	0.00449839
NZ_CP045178.1|WP_077969127.1|8337576_8338551_-|mannose-binding-protein	gnl|CDD|214519	smart00108, B_lectin, Bulb-type mannose-specific lectin.	8.1471e-19
NZ_CP045178.1|WP_077967683.1|8396495_8397347_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.50241e-28
NZ_CP045178.1|WP_077967677.1|8387332_8389930_-|phosphoenolpyruvate-synthase	gnl|CDD|235751	PRK06241, PRK06241, phosphoenolpyruvate synthase; Validated.	0
NZ_CP045178.1|WP_077967956.1|8395724_8396129_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	8.37253e-15
NZ_CP045178.1|WP_143621232.1|8359340_8385548_+|lonely-Cys-domain-containing-protein	gnl|CDD|380151	NF012197, lonely_Cys, lonely Cys domain-containing protein. This model describes an unusual domain, over 700 amino acids long, that is largely restricted to the Streptomyces (prodigious producers of natural products) and that may occur ten or more times in giant proteins. The most striking feature is an extremely low cysteine composition, one residue per domain, and that in an essentially invariant position.	0
NZ_CP045178.1|WP_077967676.1|8385956_8387165_+|acetylhydrolase	gnl|CDD|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	2.28623e-08
NZ_CP045178.1|WP_152330856.1|8344966_8348974_-|type-VII-secretion-protein-EccCa	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
NZ_CP045178.1|WP_077967681.1|8394307_8395498_-|fumarylacetoacetase	gnl|CDD|215461	PLN02856, PLN02856, fumarylacetoacetase.	6.51241e-153
NZ_CP045178.1|WP_077969129.1|8343427_8344672_+|S8-family-serine-peptidase	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	7.92065e-42
NZ_CP045178.1|WP_077969132.1|8350883_8352470_+|type-VII-secretion-protein-EccB	gnl|CDD|368288	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B. EccB is a family of largely Gram-positive bacterial transmembrane componenets of the type VII secretion system characterized in Mycobacterium tuberculosis, systems ESX1-5. Translocation of virulent peptides through the membranes is thought to be mediated via a complex that includes EccB, EccC, EccD, EccE, and MycP. EccB, EccC, EccD, and EccE form a stable complex in the mycobacterial cell envelope.	5.87124e-90
NZ_CP045178.1|WP_077969131.1|8349431_8350838_+|type-VII-secretion-integral-membrane-protein-EccD	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	8.62986e-34
NZ_CP045178.1|WP_077967680.1|8391107_8393423_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase	gnl|CDD|235367	PRK05222, PRK05222, 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional.	0
NZ_CP045178.1|WP_077969134.1|8353374_8353683_+|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	3.33641e-07
NZ_CP045178.1|WP_077967673.1|8358429_8358885_+|YbaB/EbfC-family-nucleoid-associated-protein	gnl|CDD|376829	pfam02575, YbaB_DNA_bd, YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure. The conformation of the DNA is changed when bound to these proteins. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage.	1.06425e-08

Protein sequences

>NZ_CP045178.1|WP_077969135.1|8353809_8354277_+|type-VII-secretion-system-associated-protein
MAGDKADVKHFDLKQMENFRDNEVAPVYTAAKKHREDGDGTHIRPLGQLIDGHTTADNLTQDQQLLRIGKMVTEPLVSGPTLIENVRTAAESIDKLLGDQMDLFKELKEALTETIDEANKTKNKNLEAIDAQTLLQTFEEVDTLTAGGAESSDET
>NZ_CP045178.1|WP_077969134.1|8353374_8353683_+|WXG100-family-type-VII-secretion-target
MSEGIIDLQFPLARQAIEELRGQTQQIIETLNRLEDELKPLVTTWEGSDQEMYLVVQQEWDAATKRMAQLLGDSGDLVQMIHDNHSRDMRKSADNWGNVRAR
>NZ_CP045178.1|WP_077969133.1|8352947_8353283_+|hypothetical-protein
MADSPERKADYAKGLGGVSSLESARSQVEKIQNNVAEIAARSGVGGDEGTALMKLFRSWTAESQKVVVEVSKMIDALQENVTSADRVKKENEDYTQVLTSKTSQGVFDALR
>NZ_CP045178.1|WP_077969132.1|8350883_8352470_+|type-VII-secretion-protein-EccB
MQSKRDQVQAHSFMMGRLSSGLLTADPDAPESPLGRTTRGVVFGVLVTVLISAGVTVFGLLRPGGNDGWRDGKHLVVNRDTGARYLWTGTDGVLHPVRNYASARLIGGADLASVDVATASLRDVPVGSSTGIPGAPDAVPGPDRLDDGAWHVCVTGPDGPLPSTSGAVTGTVVYEPGATTLVAGAPLDSHQVGGGKGVLVQGPDDTEYLVWRGSRLPLDRASDARNALGYDAERPMPVSAAFLDALAPGPALKPPAVPGRGGRGPELGGEASRIGQLFKVSVPGGGSSTYHLLQKDGLVPLTRLGAALVLGDPATQRDAYQGRSPEARVVGADVLRAHRAKDASPAGSADLPDAPPVPQHTRRGNALCAQVDGDSGGTRIRSVLVPLVGLAPVVVSEKSAQPLAPACVRADATVVRPGRGALVRALHASGAAHAGTTYLVAENGVKYRVFGAESLEALGYASSDIDSVPAPLLSALPTGPDLDPAAASGGAEPRVTAPECGSDARAGQRAESDVTDKAVSARTVGTVS
>NZ_CP045178.1|WP_077969131.1|8349431_8350838_+|type-VII-secretion-integral-membrane-protein-EccD
MTDSSVAESCRLTVRAPSVTVDLAVPSDVPVADLLPTLLRYVGEEAEEAGLDHAGWVLQRLGDAPLDDESTLAHAGLFDGAVLYLRPHTEALPEARLDDLVDGIADTAAKKLHTWHPGAARRLLVGTALATVATALVLVFQPGVTGSGSLRAACAAVAGVLLLAGAGSASRAVGDRLSATALGLLVAPCLALAGWVLPGGDVTGPDAARVVGARLLAAGTAGAGGAVIALAATAVGAPALLATAVVSAAAAIAGALLGYTALDAPAVAALVSTVVALAAGTVAPFAFKLAGMRMPSLPSSAGQLQQGIDPYAGDEVAERTELAGRWVAALFAATGAIAAAALVVLAQRPHLPETLTALALSLLLLLHSRGLVHIGQRLTLAVPGIWGLLLLARAWATDSGGDGRVVVFAVLLAVAAGLVTASWIVPGRRVLPYWGRTAELAHTAFAVALLPLTMWVAGLFGYLRGLFG
>NZ_CP045178.1|WP_152330856.1|8344966_8348974_-|type-VII-secretion-protein-EccCa
MPEGQLTLQEPPVLAEVVPDTSAIWTYLPMALMSVSMMLMFLRPGGGNGVFMYLAMGVMALSAGAMLLGQLMRRSSERKQRLKGERRDYLRYLAQTRKRVRVTIAEQQRALAWRHPDPGSLRSLARTSRLWDRRPSDEDFGEVRIAKGEQQLALSLEPVSTRPVEDLEPLCAHALRRFIRAYSTIPEQPLGLYLRSSARILLRPEGTPDGDQAASGPPPTGEGGVGQDQGPGAEAVRSLARAVLGQLAVFHAPEELWIALCVSDERRADWEWVKWLPHALDPHEEDGAGQARRITSDLTELDDLLGADFAERPGFDPDARPGRDEPYTIVVLDGVTVPPGHRWEGHGYRNALALDVSGALRWRPGRNMLRLTVGPELVSLVRTDRSRKVRSVPLGRPDRLGPLGAEALARLLSPRRVSLSTDIAQPLDTDVELTTLLGIPDLHRHAPEVLFDRHTGSGRLRVPIAVGVDGRPVELDIKESAQGGMGPHGMLIGATGSGKSELLRTLVLGLALTNSSEVLNFILVDFKGGATFLGLEELPHTSAVITNLADEVALVERMQDALHGELIRRQELLRSAGNHTSALEYERARAAGAPLAPLPSLFVVVDEFSELLSAHREFMDLFVMIGRLGRSLGVHLLLASQRLDEGRMHQLESHLSYRIGLRTFSAMESRGVLGVPNAYELPAQPGSGYLKSGVESLTRFRAAYSSGMYRRRTGAVIRARVASQVVPWSTDWVVPRAPAPAPEPETEESGDEETLLDVALDRLRGSGPAAHQVWLPPLAEPSPLDVLLPGIAPHPERGLTAVGRSGTGRLRVPVGLVDKPFDQRRDPLVVDLSGAGGHIAVAGGSQSGKSTLVRTLIAALALTHTPAEVQFYCLDFGGGGLSQLAALPHVGGVAPRLNPERVQRAVAEVMTLLAHREQFFVDHTIDSMQSYRRRRAAGEFADEPFGDVFMVVDGWSTVRQDYDDLIQKFNELAARGLNYGIHLLISTTRWVELSAQVRDQAATRLELRMGDPMDSEIDTRKARSVPRSGGRGITADSKMHFLAGLPRLDGSSSLDDLGDGVAHLVAEVARHWPGAPAPQVRMLPHRLPLTELPAPEATEGDGLRIPLGIDQDALEPVWHDFSRTPHLIVVGDTESGKTNLLRAIARSITTRYTPDRAKIIAVDYRRTLVDAVPEEYRIGHVISLDNLNETIEGAARAMKDRVPGADIAPARMRQCDWWTGPRLFILVDDYDMVAGSTFQGPFEPLFGNLALGFEMGLHLVIARSAMGAGRGLSDGLVRRLDEANNPAVLLSCPPTEGRLFGNTKPLNLPPGRAQHIARRRARLMQTALVEEAQEQ
>NZ_CP045178.1|WP_077969129.1|8343427_8344672_+|S8-family-serine-peptidase
MSPASHGVTRLLTCAGLTAALLLPAAVPAVAAPVRGVPAAEGEKGQELPAMPTALDPEADETACTPASRAKAEKQDWSRQRLDLDRLHRQSDGAGVTVALIDTGVASGAAGLDGRVSAKGAAGDDCVGHGTFLAGLIAGTGGENPRLAGVAPGAKILALRGTDTRGRAGAGLVVDAVREATAAGADVIAVAVALPHRDGALTRAVASARRAGAVVVAAATPDPPRGGTGETPSRTYWPAGEPGVLSVADMLPGGARPDDAPRTGGVDLVAPGAEVVSGGPRGDGQYLGNGAAVAAAYAAGAVAVVRAAHPEEAPDAVTRRLTATAYPAGIPQLDPYAAVTTVLGDPARSVGAERAVRPVTVRDTTAADRATGRATLFVLLGAATVLAVLWAGFAVSRARARGWRPAGAGGTDQE
>NZ_CP045178.1|WP_077969128.1|8340131_8343431_+|AAA-family-ATPase
MSRQVLSVGPGDRHQTIGEALAAARTGALISVSPGTYAENLVIRTRVTLTAAEGRGTVEIRPDTGSVVALRADAVLLSELTLRGGDPELPAVDVRRGQAALDNCEIVGAAWTALLAGGTGSLALRNCRVSNARGAGIVVTSTTPTTVESCTLEHLGTSGLVLAEQGVARVRDCTVRDARGNGLLAGGDTRGSVQDCDISSTDKPSIALEQRCAVSVARTVVHDTSTGVHLSSEGRTTLEDVRVTGASGNGITLAQGAAPVLRRCRVSRVRGQGVLVTNRARGTFEDCWVDGAQGAALRVNGAASPAFTGLTVRDCEGVGLLLEEGSAPELDRVEVIGGSPAVAVLGGAGPLLRRARLVEPAGDGITASKDARGRAEDCEIVRPKGSGVRVASGSTFYLAGGGVSDAGARGLVVEDGGNVTVRDFRVEVSGEEGVVVAAGGELTANRTAVHAPAGHGFLLREGALASLSGCEATGGAQDGFRVESTAPVSLVNCLARENEGGGLVQTTPGERLAVEGLESVGNGKRDAWGTGQAENTDPAGSGAADASPEDRADGPLGALNALIGLDNVKQQVGTLVNLTQLAQRREQLGMSAPPMSRHLVFAGPPGTGKTTVARLYGAILAELGSLRSGHLVEVSRADLVAQVVGGTAIKTTEVFQRALGGVLFVDEAYTLTADSGSGGADFGREAVETLLKLMEDHRDEVVVVAAGYSREMDSFLGSNPGLASRFSRTVVFENYSVPDLVAIMESMCVQHQYELGEGTAAALAAHFGAMERDAGFGNGRAARGVFEDMVDRQAVRLSKQPQVGERDLRLLLPEDVSDTAADTGTPDDDPLTRLGDMVGLAEVKREVADLVNLITTARHRAAAGLPVPTLSNHLVFTGPPGTGKTTVARLYGEVLTQLGILQRGQLVEAARADLVGRYIGHTAQLTREVFDRARGGVLFIDEAYTLTPRGGGADFGQEAVDTLLKLMEDHRDEVVVIVAGYTDEMRRFLDSNPGLSSRFPRRIAFADYSSEELVTIVRAQAAGMGYECGPGTGPLLKEYFDALPRDRSFGNARLARQVVDSMVTRQAGRLSSLAAPTLDDLRVLTPADITAAPSKVVPR
>NZ_CP045178.1|WP_077969154.1|8339077_8339935_+|type-VII-secretion-system-associated-protein
MRNGARQESVDGVSFPHADTSGAHADTSGPPADTSDSSVGPEMSGPGDSGVPEVSGTPEAVRAAARRAPGHWVGVVDPEWTAERTPPEWAVLGEWRSEEDGSVGEYRANPAYLPSARALGWPEPTDPVDEAAQRAATGYGTVAAALAALAEADVAVVRGPDGGPLTAAGRDGAPVVLLFTSPAHEFMSEALHHDTLPALELVRSLRGPGTMLLVNAGAAAPLLIPADSLLDPPRTPDDETAAAADTAAAEEAPDRSADRTGAPAAPRTGASSRPRLPTTGRTSTP
>NZ_CP045178.1|WP_077969127.1|8337576_8338551_-|mannose-binding-protein
MPLKHPTPGAKATAAAASGEQEAGSPPPAPAEETPGPAAVPETEPGTSPAGENAATPDQAAAGAAEAPEEGVAVATAVATAPATKTGTGVDGGRPRTPILAGAAILGAALIAIPLLLVGNANDERDDGAKGSTTEGADTVLSMDSAPAVPEDYKTAKPSPSPTRKKPEKTETPKAAAPVPVVPTAEPSPSRTAAKKPAPEPKPKSSPKPASQAASQPDWKTVTISAPSIIDVNQAWSTNRIRMVMQPDGNLVVLNEHDKPVWASMTFGSNHRAIFQSDGNLVIHNGDDRPIWASKTHMYPGAQLVLRADGKVVIEHNGQVVWST
>NZ_CP045178.1|WP_077967673.1|8358429_8358885_+|YbaB/EbfC-family-nucleoid-associated-protein
MTEPLEKRLEKAMAELQEAQEAVARTERELRTASFTALSSDRAVRATAGPQGELTKIDFLEYKYRDMSPQELAASVLEASGAARRKMNRHVMKAMEPFTEPSSNVPELKGFEMDWERVFGPEVLREDDENPAREGQATPVWRDALGEEGED
>NZ_CP045178.1|WP_077967674.1|8358887_8359259_+|hypothetical-protein
MGPRYYVDPQRIEALAGQLEEIGALTRSMTEEFLDGLAPTVNWPGTEGDFAEKAKPQEQKERQNTKDTMMSIRDALVGITDATLSQVRMMKDTRDHNIEGIERGTDSIDTDGFDSGPAGHGRR
>NZ_CP045178.1|WP_143621232.1|8359340_8385548_+|lonely-Cys-domain-containing-protein
MSIRVSPEVNAMIFILTGERLMDADEDLAYESRRPYSGLGRKLGRLSSLIDKSVHDIGESMPDDLAKSYAKAMGTLIDDGGKNYLRDFAEQLDKIAEGRRKTSMDIMESKWQVIAEVIRLLIEIAIYLAMSFFTGGASASQIMMAKLRSRFFILTTLSHLLQRLHIAPSLTEAFEEAFTTFAVRLAMMNFAPDGRRPDKFDWNDILKSAAFGAAAGGLTSVFDDFARKIVRSYDGNFLKDGPDLDFKYHPNPRDSPKLDLKNPNPKPNPKPNPHLKSDPTPRPYRDDTPIDRPDPTPYRNSPNAFNNPPVTFRNNPLSFRNNSNLWRNNRTLRFNTDRPGALAGHYGLKGTADFLAAGSGEALGEILIKGAFDGDWSTSWSTFVGAGISSQVEATLTASALNSGAELRHVIDKLRLQPPPGVSAGDAGTRDSGGPPRSDDGPEQTEGPGRSDGPSRTDTTGGDDPAFTSSPPVARQTTGQGGLTGDQPPPPYSAEDPPPYSYEDPPPYTTLDPPPYSPGALPVTAAENELWQQVHQGPAEVRAQALRDLAVLRGAQPPSDAEIGLRDSLHGNLSPLPEVRVVSAGNSPAAQVDTDEVRRALGGFGTQVTVDSPSPSPSPSPSPSPSPSPIAGVGVGGVPAPGDGPAAADDSALAGTSDTSDAPTAPTAPTAPTAPTAPTAPTAPTAPTAPGVSGNSHGSTTSDSAAHPAEDDSGVLVDHDSDVQGDDSADRQGATPGVSSESGGQRSPGTAAGHGDRTATVLDHGDGAPVAAKGPAASATAGTGSGVRPGGAPTTGSGPASSVTSPQSSRSSDGPASADGAVSADGSPSATGESSRTDAAPAGTDTPSAGTGGPNGTGVDPDSAVSVPLPAVGTVPPSVDAATAPPKVDTIGSFDSPGDVRDMRDVREAWDGSGPADRKAPPAPDANPGATQAPPLTIVVSEVPPPGEGTPETAELLDRAGTDRAVVLGPAVAPDGAGRPVRAAVELTREGPGAPVRVRPLTGPAPTVTTDGATGPAFPGADVLLPLADALGPAPDPALRTTSTTGRAQSVESPAVFQEKRSRPPGDGTGPHFDVVTAPTKLATQSRPWTESATDLYLESGEGSTDPAPDTDPHTDRDGDSDTAGTGGRAPGPGAGHGTGTGNTPLAPSVPSVPTVSEATPVTPPVVLPPPAARIVVRPEVGGATDGDGEGHAPRQPTGEPAVVTLDGLTVPLSQLRRLVPDAAVQPPPGRAVRMLTISQSPAEDGTARDAGRRALLGQDTFRGVRTVSAPAAPQRPLTDSDAEAEVSTPAPRTVFTGPPAPLPGADTEQGADYFVGHGTSRTVTLGTDDSARPGVKVSGVQLGVVLTSWAVDGDQNRPLVLFSCETGRQPEIAGLPVAQHVANMTGRPVYAPTTEVGTARDRDGEVRAVLTEGAGGPGRWRLFTPEPGGDALDRSARDAGLHAGPGPADAFTRARTLQQIRTLRDALGPDAEKLPRNRESLAALAYVDGLRWLGTDSAARYGDGRMTPELLRRMVTDWHTVTGATTAATTGDPSAGSTVEQSTGPTTARYTAFLRAAAELRAGAGPSTTLDELLPPPPRVLSPNTPVTQEDVRGLAYARSARVAWSLSSAPLPLSDLALSPEDTAELARRQDSPTPATSRPGSPAEHLTLFSQGPVKPSDTADLVRADGHAFLRVQARGDGDCLFRSVLDSARGRSVPPAWAARNVAGLRSLVRDRVTGSELGNVADTAVPDPVFTVVDDLRMRALAGVSDADEQRRITEEWNRVAHAVITDGDPGQWRRLLADSDYPQLAQVAPTPADARRFGGRGLLAAAAERPGLWSSPFADLLPEALAHTLDLDLRLVRPGPAPQMTGAPLVTTLNPGGSGGTLHVAYNGTDHYDALVPAPVTSAPVTPTPVTTAAPQVSRKPDGTGPSGEGAESKSWTTDTGDAETPDKGDPVPLETQLERYRPARLLTGEDARPPGPAPRTVTFEDGSALPTVLIRPDADPEDGAPGGRTDRTTRDPAGLLPGAGRTTLRSPEQVAQEILDKLPKKLRSQFDEAELLRLLTEQPSAFTAPRGARFVGREKSGVGHEMTVEAIPYHRWERFSDVDGGTLRLDTMRRGQAGTAGGRGVGFGRRIAGALSMGPPLNWLLKIGVSLGWTRRTDYVQGTQAYNQSEWRGWEGSHLHLDDVHYRVRVVRVTEAPKTTGQDSRPGPGGVQDSRTNSATSNLRWQRTQVHSAEFAMRDGLSWRLSDDLTVPYTGPRRAPKTLTFPDGVEPRITDVTGLHLSDPPEELALAVSGARPGSSAHRTLVSYVRPGRMLALFGRFSGSVTGPELTRGSGQHPLGHLIVQRSVPHRATLVTESVKAEVRELTQTTYQNERGHVRDTRFGLQVTAGPNYTLAGPDTDVRLQGGPLVRADLSSGRGHYVGADTARKTTGRVRNHPVALYRVERTLMVRGPGEPPSAAHPVRVVSLDWISTQDARRLAGWDSRTPGRTGPNPDAEPPVPWYLTREDPVHLSGQVRAEGFRAVRPQPQPQPQPQLQPRPLPRPQPRVQTRTSQPSPGTAPRPGAQPQVQPPDQGQQPQPQNLPQQSSQDDLQDPMRAFADAVLDTLHRSYPSLFVPPLMLRHPRLARLWYGDGRMRTALHNDRQVREALNRPTLAQSLDDLTTTGVPVTLVEDGKVRRGHHTLVLGARLTDRRFETTMSERSLRNAVIGTEISGQGQQAAITLSGGVELGVSPRDHDKAPGAELPRRAGNVSLGARYARTDQKATRNTVAVSHDNLAFQAGADLYSYQVELGASFEGHRRPRGWARLASVGLLGAGLFVSKIEERPLFTRGNETVGRVELAVPVAHGSERHAPADPPPGGPAPAPAPVSVPRWLSSTEADRLLDGTRPSPGKDSPDQRLTRRLLRAPHVVLSTEGGKQRQRLVQDTADRATGASWHVSAPGAPVRTALRRAMANLSVAGQIGQYLGPFGSRVTGLNGAGPLQIHYLKAAVRGELHNFRVRSDPKASSLEATLTNEHRVAGSASTVSRTTLGLQGGYMPLQQAQGQGPVVGSYTTALQYAWAKGRGVSQTLARGRGTTLSFSGRMYLVVADAVETVAVRDRWTAAMGAVGTRAGARISSAAGQLSGRLADALAPRGAAAALQRIRDAVLFHLPMQDVIEAGLAPDGLGTSTPRNLGGGYRLSPFLRDRRFSSHPSGQLDASRAAHLLRRQLERTGMSSHDREQVLQRLSPDFLRAHLHELTTGGMTLPVRHRTWSSPFHLPVGGSPGQVRFELNPVTTTVERLRTGFELEDYRNISRDDADNTSQDRGGDATLSGGERAADSGILIANPSLQGTAAKQRSTTRTQATGTLSMPNIATTQAHAEIVTGYTLTVTMTDATGDPLAPRAVGVPVGSLSEFLPASLLTPTGDGADGALTEQNVPAPERAVRLLTADRARPDSIAAWRTSTSTSGAGTISGTGTGTGTTSVTDGTDSDILPFDDKIGSGILAVDILGAANVRDALTLATAVADGHGDNDLGNRLAGKSLDARVRIARLTPLTGLGTAPAQAQQEATSQGGLTAGFREALGAGGSPLPAQSSAQLLGQFHTADSRLYAKMHRSGARLLAVENKPRMEAMQRAKTTDALEAGITDNIEGAVGTAPLAGNSNAGVTNPGGTVPIGGANDGTVLKGTVDSVLGTHLKVVTDRSMLFAVPVSWLSVAEVDHRITDSRPLYALGKAKRGPRAAEAETTALIWLREDLARDYGLLDDTTYPDEVSTAWDDMAKAAGDLASAEKEYYEARARARETWLSLSPGERTALGDDDPALSTVLPRDLARSPAVIAWQAARDDVRLWEGRTDAAAADHHRLHLAASRLTAHHRSPTSGAVPDGPQEYVKPGWRSEAPEPYKITEATEPTADSPGTPGTAGISGTPRTLTSPNGATVREVHAVPHDGASFFHALLAVAETRGRLPHLLGSDLAGRFAGAHGDPSVTAEAIGAARDRLAWALGEDSNEDLLDALAPDATDTFTQDELDTAGVVLTPAQQAEFDAFGRLPLTFWPTRDQRVALTTAALSRPFASEPSTTGTEEPPGGEGTPPERRAGGHGGADLLPALAARVLGTPLTVVTAEGHEELFLPHGVDRAAVDPAVDPVLFSADGFFHAALPPGTPPPATAAPPAPTTAGSSGTDTGDPTTGQRTEPPAHRSHTALPWKPPAESGGPRYRLDRDGFLAAPDGATYAQGAPSGRGNGFFGALSTALHHAAGRPGVERDEAARLRVRAGSSPARLMRLYGLPGDPAERASLFAPPPLASRGGAPAPSTNALESHLRRHLAVAPWGTGADRAMAAWAAVATGATVTLVEENGTTHTWTGPSGDSGPHIRLRRRGGDFVPLLLRTPAPAPKTPATSLTDAAPPAAPVPPVSRPDDPAAVPLPPSPPVPQQDAVAVPLPPAPAVSDTPSAEDVPGLPGEEEAYELSTLSGAEGAGPARQGGRPRPRQSAADALAQFRFTDDAETEALARFRFTDDADDTDGSDSDLDSEDGAPDTGPEVWVDLLFGPAARHDNTPETLVGTAAALRELAQRGTRPSSATTSPLGALRALTRRVLSFRPDASVRAQDLLLLGSLALSASARELADEGALAAYLTSHDAALDQGTRLVSEHGTGRNWTGTGQQVPALDSYAVEGEDGRLSTWPAPWADPYTVFAQVTADSVRLHTPRGTLTLDDPGELARLVARDPQRPVGADVVLAFPHDGAETLARHVAALTGARVWYSRYHPRPSTDWRTGTDHIMLGPVPEGIGTVWDSVGPARGADSDGDTDSGGDVVADIVGLYEGDSGPGEGIAGRRAEPLTTTEYGIVDDRGTGVLFRRPGGIRGHLRTPRALEGTRDAPELAMSVQAHHETLVAERPLLRISEDRTLAVESGAYGQQVFATEAAVARASAKLSRAGTAVRLRADHDLSVILPTADGGSRRLFLVTPVFLNGSGKSTEEVCRDFADMLADNARTSHLVFRAPQGGPAVTAPVNASDGTEVTGTHHLADALSHVADGDLRPDETNPAWAATFVRQDDRPTGGDGGGPLPGRAYGSALSLAEPVDPRRDALSDAAGRIGVNEHAWADIGEGYVVQSVAAPGEQGQPSLEHNYAKPQTDSSGTHFGYHFATVVLASEDGSHQISLENHARVSVRNHRHRRAVQANLNRYGLDDLREIGSRLRQEIERRQEAGTEEHLAELRANLDLSLALARAKQAGTEMSEAPVGSPEHVAAERTLEGATRAAALRVGHLEQVIPGKHHWYMRMYSRRPGESAHDTNAELLSEGRSAEPNPLTAVVLRGQQAVPVSISFDKGVQQTPASAKFSVRHLAKVVARTALWNAANGLPLPDIEVTGRRPGRFGVRDVAKARAEAVAASFRSELAEALTALQDGTPQPHLTADRFTVESVSVHDRRSSTGDAGTGIVDVTVEDHRGGPRQVLTRGSRGGSARGGLPGGSRDDGLDPVAEQWPIGRPVTVMRPRFGGVDPDFVVPVSEAPLTEVPVTEAPTDDVPMTDVPTGTGATDTGSTPADTGSTATGTATARSAKGKAVATGTGTADNAPTPSGSRPRRWFTYTRSAQSRSEPFRYDVADTGHIVLPEGEEIPPAGWTRFGHDFVHGATGAILRGDSGWIGRVANMDTLSLVMADLDQGAAPHRVVADSSALYLVPEGDGDTALRIPLREATGPGAPDTPGGPPSTVPREPATVAEDPSPTAPETPSTTAPVSPSATAPVTPSATASESPPASVPVHATAPEPAPRPRAPRARLDNRPRYVVRSAFDVRRFTHGGETVTDLTVRIAFRRGDGQADTDTDAIMARVRRGVEEFYNRPGHTLPGGDRLHVTVEPSGPGREPHLTVDLVDRGRRMNQRTWWADAEPVEFAHELAHQLFLRDETRGADNPRRLHAPGSLLGPPHEQAPDGLAQSGLRPRHLQVWAAVAAGVEPHTSPEGTSWADARTNAPAERREPVWVDPVSLPEATSETGPDGAVPPPLPPGQAMPTLAEASDESESETDSDDEAERPVWADQGWLDTLFGPQRAGIPRARLRETSEALYGLVRAETTTHPTARSLRNGLMRLTRNVLHMGNADAPGPADFLLLGSLALDASSDDLASADVLALYFMERQIETGRGALDESTLLRDDEGNALGRDFTGPGRSAPELDSYVVRGRSRVVSRPAPWQNPYLVVARAVGQAVEIVVPGRTFRVNSADELAMFISYDPRRPRGADIVLAIPTEYAATVANLVVGTTGRRVWHPEAPVEVATHPTAGTRHLMLDLSDGRTGASWASIVPIPVDGLPGARDLSSESDPGGPSGRDSEVDRSSSDGDAQFDRMVEQAVLERQVEGRRTRPLTTRSYGVIDKRGTGVLFTRPLPRSVGEAEAGSAAGPALTLFLPLQELGDIRTADRPPLHISKDRTLAMLAAEDATTGRGRQVYATRAVIERSSQRLAAAGAGVQLRADDPTGVLLPDADGSYGEPLFLVEPKFLTPSGGSEHAFTRDFARMVAGAASAPLSHIAFRGPTGGVVSTAPVNGLHGREVTGTHHLAEALAEVAEGTRPATEVTPRWAARQTGRDPRFTGGVVGAPTPGERYGRALSYEPVENPLRTPLASAALRIGVNEYAWAGVGEGYLFQSISTTNDSGAQLFTHNHAKPGDRVGPHAPNHFAQVVMDSEDGTHQITLENETHSRDEIPDEVLDAVIDENLDRYGEDRLNRLAHGAEQRVAEARRSGTEDSETDHLENFARAARALAEVDRAEQLPWYFDEDRPEHALALREVAQARSRAKELIRAAAPVIDNKDLWFFRAYSKRPGESAHEVNAALLSESSPMVANPLTTVVLHGHAPRPYQRTIHFDEGEHTLPADAAGTIEGLALSLARAGLWNRAQGLPMPTLTVTGHGNRSQASGQERADAVTRALAARLARLLRNFQTGTGEPRVGVRDFGLTKSAKRVRLATDPARGRVVTIQIDDHRLVPPGPSGHTTPVEEANPSDEPALTRPTTGPGTEPETVTGPASATDPATTTERIGARQRNRSAQTSPERRNSDAPPWVLARIRYAEESAAFDRRLGEYLSEHAAVTAEFRKMASAAWASARRRHPHALATFGDTSKYKAGVVGTSREALQRVVRSGNLRELVAFLYEGISNDLVPEMLGGAEEQHPEIAEERPSRRQREAYAAFMRRAMEISASDMSPAQKEAAVEELQRPLVAPMAPEAARPPLSEAERRFGTNTSGLTWMPATSVYDIAMSADLQGRSEDSGGLVATGTAGSTYRFLLHAARMREQWGVDLDLGLIRAGMLAVSLTVGHHTVHEVLRGAQLALNDVPDHDRALDYADNWGRYWNVYPLDEREARENIARNGLFPDEHARALLDELETGTATDTGAGTREGDVGARAVLPHRQGPTRPAHTRPVADESNHPAARRPDPAGAPATSGGTTAAPRIVTPHEAERHREAVLDALYGLGALNGVDRESATVSLERLDRIREADPELRGGFLDLDTLVRRILLLAPSDTVNASARGALVRLVAAAADARTPAALSAHYLVLRGAFHSDFRLTGDRGRPSGWNWLDLPLPADFDPGSTGRIARAPDGTTGHNGPETAPWLAAPDQHAPYLVLLAGRSDAVLVRGTGGFSTAVSPEIFHELLALDRDLAARPGPMPLLLQVDRPTAASLDLPRGLADRLGRDVWASNGRTAVGRLPKVPDRSMVLLLDEEKRAPRGQWFLNTPVTAPPPPAEAADGQVSAVSIAHHGHRSTGYISMDLAGSDDGGWSRTLTHSRLGTVTSYAFQRTAYSPEGAHSVVPWVELGLPSPYFPNNHGLPGTVMWHTQAGERAENGPRFARGLARRRSLASLAPEHPVVLLICYAATPPGIGEMHGRHIDGPLPFVPDPLATVAVAQHAANETGRTVFATVLVNAVARSRSGGPQTYISLLTDARGRAYEWVMFRPEPTGDALDRWARDAGLHLDPGPVTAAARGRTLRLVRALRHIFGPTVDESPDHPALLRGMGALDLMREADPHLDHDGAREFTLDLYEHILTRYHAGGLRQGQPPQFTPDSHRSLLTEAARRWDSGTRPPLTGWIGLPQLVHMLAGLGSSPHRESIARQVLGVDAAAPLGEAEWSRLLWASFKVALVTAGAEPGAFAAAVLHLSAPDPARFGEAVLAARQAAAVGRDPRRLHEVAAHHLELQGVLGSDRLLTDDQGTTWGRALDGTSRPRGTFDPSVVTLLGHAPDGSLVPVGTERAPWTADPHRPTPFVYVADGDSDGLRMPGPVPPRDFGELVFRDPELLSEDGYAEVVAVTSHGRPPGAQPVAAESIPGEGARNSARNWWTTHSAATLHHDPATGTYTVALLPGPDGQRATAGSWGRTTPPEADPSATSGTASATNSVTPGRAGAAAHTSRPSGNNHATATAELDPAWSAHARAVTALAEAAAEAATAERVSGDGAVVADAWAGVDLARRRVEDAEALLSALGVAPHALGAARSTGESPATGRAGAAASGAAAPVVPRSDRERRWIAARLTEADLPPGPPRPIGEGTVGAQDLEAAGITLSVGPRTEMALRGDNRLPVAALSPLDQVRVGMVGRGAWSDMTHTVAANASRRLWARACADFTGAAPEGAGETGTTRAWDTAVSLVLPAEPHPVSADSRYAGDGFRDAVRLVADHLLDTRAGTGAAPTSAAELADNLRVGLGLRRRWTASATDTASATDTASATDTASATDTASATDTASARDMASARDMASARDTASATDMASARDTASARDTASATDMADDPGTAEDTDTV
>NZ_CP045178.1|WP_077967676.1|8385956_8387165_+|acetylhydrolase
MTTRPFISRKGTTRRRVLAAGAAVPLAAIAGPAWAGQGAPTPVRRRLTLPVPTGPHPVGTVPLRLVDRSREDDIAGPGHFRELMATVWYPAGDIDRYPVAPWMPAGALQAFLADAGFGDLAPLAPFTAGHVGAPVRRSGRRLPVVVFSHGARSHQGDHTTIVQELVSHGYAAVTVAHQYDTYTEFPDGRVAVPLDDREAPTLPGDYAADLRFILDCVEQIAAGRNPDVDRRELPAGLLGSLDPRRTGAFGWSKGGTATARAMLTDERVLAGLSLDGPMQMNPPLTVDLDRPFMMMSAEFTRATDPEAAAFWSHLRGWRLNIEAEGATHISYGDNEALFPQAAKVYGWSEQQLQELIGTLDPDQAVKIQQAYPLAFFDQHLRHRRGHLLDGPSPAFPAVTFLP
>NZ_CP045178.1|WP_077967677.1|8387332_8389930_-|phosphoenolpyruvate-synthase
MIEQYVWDLREVDETRVAVVGGKGAHLGGLSRIEGIRVPDGFCVTTDAFRRVIAEAPSIGALLAQLSRVDRDDREAIRALSERIRRTIEEVAVPDDLAAAITRGLARLGGESAYAVRSSATAEDLPTASFAGQQDTYLNVVGSAAALQHVSRCWASLFTERAVTYRLRNGIDHRTVQMAVVVQTMVLPDASGILFTADPVTGHRKVASVDAGFGLGEAMVSGLVNPDVFKVRDGEVVARAVAAKKRAVHALPTGGTREVAVDPRWQEQPALTDAQVVRLARLGRRIEARFGCPQDIEWCLVDGDFRFVQSRPITTLFPIPDAGDQENHVYVSVGHGQMMTDAMKPLGLSMWRLTAMVPMREAGGRLFVDVTRRLASPASRAGLLDAMGRGDPLVRDALETVLGHEGFVPSLPDAGPGGPPAGGTSAPVEADPAIVGQLIERSRASIAALEHDSRKKTGPALFDFLLDAFEEHKRVLGDPLNMRAIMAGMEATWWLNDNLWEWLGEKNAADTLTLSAPDNITSEMGLALLDVADAIRPHPEVVAFLRDVEDDAFLEELAKLPGGAESRDAIESYLDRYGMRCVGEIDITRPRWRERPATLVPVILDNVRNFEPGAAGRRFEQGRRTAREKEQEVLARLRALPDGERAADPAKRMIDQVRAFAGYREYPKYDIVSRYFVYRRALLEEAGRLVRADVLPEEEDIFYLTFQELHEVVRSHQVDDRLIQRRKEAFRSYRALTPPRVLTSDGEAVTGAYRRDDVPAGALIGLPVSAGTVEGRARVVIDMTEADLEAGDILVTPFTDPSWSPLFVGISGLVTEVGGQMTHGAVIAREYGLPTVVGVEQATRLIQDGQRIRVHGTDGYVEILS
>NZ_CP045178.1|WP_077967678.1|8390721_8390964_+|hypothetical-protein
MNSVSRKATLAVGTMAAAVGLSLFGVGTASASPLLPYQGTVYGSLGQCLTKGNTLAQQGAIVTFNCEPRSGGRYAFYYTT
>NZ_CP045178.1|WP_077967680.1|8391107_8393423_-|5-methyltetrahydropteroyltriglutamate---homocysteine-S-methyltransferase
MTSTSAAAAARATVYGYPRQGQNRELKKAIEGYWKGRVDADTLLSTAAGLRRDNWRQMADAGLHEVPTGDFSYYDHVLDTTVMVGAVPERHRDAVAADPLDGYFAMARGTQDVAPLEMTKWFDTNYHYLVPELGPDTVFTADSTKQVAELKEALALGSAARPVLVGPLTYLLLAKPAPGTAAGFDPLTLLDRLLPVYAEILSDLRAAGAEWVQLDEPALVQDRTPAELNAARRTYADLGVRTDRPKLLVATYFGRLGDALPVLAKAPVEGLALDFTEGAAANLEALASVGGLPGKRLVAGIVNGRNVWANDLTKSLSTLGTLLGLADRVDVSASCSLLHVPLDTAAERDIEPQLLRWLAFARQKTAEIVTLARGLARSTDAVAAELAANRAVLASRAVSPITRDPAVRARASAVTDTDARRSRPYTERASAQRSHLGLPLLPTTTIGSFPQTTEVRGARADLRGGKIDIAGYEERIRTEIRYVISFQEKAGLDVLVHGEPERNDMVQYFAEQLIGYLATQHGWVQSYGTRYVRPPILAGDISRPEPMTVRWTTYAQSLTDRPVKGMLTGPVTMLAWSFVRDDQPLGDTAEQVALALRDEVNDLEAAGTSIIQVDEPALRETLPLRAADRAPYLAWATEAFRLTTGGAEPRTQIHTHMCYAEFGDIIQAIDDLDADVISLEAARSHMQVARELAGLGYPREAGPGVYDIHSPRVPSTEEAADLLRTGLKAIPAERLWVNPDCGLKTRGWPETRASLDNLVAAARTVRGELSS
>NZ_CP045178.1|WP_077967681.1|8394307_8395498_-|fumarylacetoacetase
MTTWLDLASDDPFGVANLPYGVFAPPGGQPRVGVRIGGRVLDLAAVLRDSVFAAPSLNAFMARGRSEWTRVRALITESLSDERHRDAVEPHLHRLDEVRLSLPFEVADYVDFYASEHHATNLGRLLRPGTAPLTANWKHLPIGYHGRSGTVVVSGTPVRRPSGQIKDPDLDAPGFGPTRRLDIEAEVGFVVGAGSALGRPVTTAEFAHRVFGVCLVNDWSARDLQAWEYVPLGPFLGKSFATSVSPWIVPLDALGEAWTAPPARDPAPLPYLADAGEQGLDLALEVRLNDERVSAPPFAGMYWTGAQMLAHLTVNGASTRTGDLYASGTVSGPVPGEYGSFMEMTEAGRKPLPLADGTSRGFLLDGDEVTISGTAPGPGGIRLGLGEVSGRVLPPG
>NZ_CP045178.1|WP_077967956.1|8395724_8396129_-|ATP-binding-protein
MASYDPWDHDRAVDARHELPTGGADARARVRDLLRAHAVLPGQVKLADMLLVTSELVTNAIRHGGGLVRFEADLTEDGLVLVVADRSTEPPRVFRADDGRAVGGYGWPLTCRVAAEISIRPGPGGKTIRAVVSL
>NZ_CP045178.1|WP_077967683.1|8396495_8397347_+|alpha/beta-hydrolase
MPSMTTDDGVRLHYLDEGGDGPPVVLVAGFKAPATSWKYQQPVLAAAGHRVLSLDRRSHGGSDDPEHGHTMARHGEDLDQFLAALDIRDAVLVGGSMGASTIWSRVASFGTGRIRGVVTVDQTPRMLASADWPHGFYGYTEENRDTYFADGVPQTGRGTSPLRRPDVVPRLVSALGLSLKDGLKRPPLSPRALALLHDHAVSDWREVVDRIDVPALLVAARDSELWPCEHAAAAAEHNPLVGSVVLEKCGHAANIERPAEFNRVLLDFLTGLGDTRSGARPLG

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP045178_2	2.1|1081100|42|NZ_CP045178|PILER-CR	1081100-1081141	42	NZ_CP045178.1	1081544-1081585	0	1.0
NZ_CP045178_3	3.1|1657983|20|NZ_CP045178|CRISPRCasFinder	1657983-1658002	20	NZ_CP045178.1	1658010-1658029	0	1.0
NZ_CP045178_2	2.1|1081100|42|NZ_CP045178|PILER-CR	1081100-1081141	42	NZ_CP045178.1	1081293-1081334	1	0.976
NZ_CP045178_3	3.1|1657983|20|NZ_CP045178|CRISPRCasFinder	1657983-1658002	20	NZ_CP045178.1	1715486-1715505	2	0.9
NZ_CP045178_2	2.2|1081200|65|NZ_CP045178|PILER-CR	1081200-1081264	65	NZ_CP045178.1	1081391-1081455	5	0.923

1. spacer 2.1|1081100|42|NZ_CP045178|PILER-CR matches to position: 1081544-1081585, mismatch: 0, identity: 1.0

tgcccagcggcccggggcggggcccgaccatcccagcagccg	CRISPR spacer
tgcccagcggcccggggcggggcccgaccatcccagcagccg	Protospacer
******************************************

2. spacer 3.1|1657983|20|NZ_CP045178|CRISPRCasFinder matches to position: 1658010-1658029, mismatch: 0, identity: 1.0

ctccggcgggagcggggggt	CRISPR spacer
ctccggcgggagcggggggt	Protospacer
********************

3. spacer 2.1|1081100|42|NZ_CP045178|PILER-CR matches to position: 1081293-1081334, mismatch: 1, identity: 0.976

tgcccagcggcccggggcggggcccgaccatcccagcagccg	CRISPR spacer
tgcccagcggcccggggcggggcccgaccatcccagcggccg	Protospacer
*************************************.****

4. spacer 3.1|1657983|20|NZ_CP045178|CRISPRCasFinder matches to position: 1715486-1715505, mismatch: 2, identity: 0.9

ctccggcgggagcggggggt	CRISPR spacer
ctgctgcgggagcggggggt	Protospacer
** * ***************

5. spacer 2.2|1081200|65|NZ_CP045178|PILER-CR matches to position: 1081391-1081455, mismatch: 5, identity: 0.923

cacagcggaaccgtccccgtcgagcgcgaccgcaggtacctgaggcagggcctggccgac	CRISPR spacer
cacagcggaaccgtccccgtcgagcgcgaccgcaggtacctgaggcagggcctggccgac	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP020399	Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence	187961-187987	2	0.926
NZ_CP045178_4	4.8|2006645|25|NZ_CP045178|CRT	2006645-2006669	25	NZ_CP015585	Roseomonas gilardii strain U14-5 plasmid 1, complete sequence	5449-5473	3	0.88
NZ_CP045178_4	4.8|2006645|25|NZ_CP045178|CRT	2006645-2006669	25	NZ_CP024587	Roseomonas sp. FDAARGOS_362 plasmid unnamed3, complete sequence	41-65	3	0.88
NZ_CP045178_6	6.2|2947541|25|NZ_CP045178|CRISPRCasFinder	2947541-2947565	25	NZ_CP017076	Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence	1654614-1654638	3	0.88
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP018075	Streptomyces venezuelae strain NRRL B-65442 plasmid, complete sequence	85552-85578	3	0.889
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	1140-1166	3	0.889
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP012399	Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence	844170-844196	3	0.889
NZ_CP045178_6	6.1|2947487|28|NZ_CP045178|CRISPRCasFinder	2947487-2947514	28	NC_015065	Granulicella tundricola MP5ACTX9 plasmid pACIX902, complete sequence	110973-111000	4	0.857
NZ_CP045178_6	6.2|2947541|25|NZ_CP045178|CRISPRCasFinder	2947541-2947565	25	MK416019	Klebsiella phage ST11-VIM1phi8.3, complete genome	597-621	4	0.84
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_010333	Caulobacter sp. K31 plasmid pCAUL02, complete sequence	80740-80766	4	0.852
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	531679-531705	4	0.852
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	756287-756313	4	0.852
NZ_CP045178_20	20.1|5895968|25|NZ_CP045178|CRISPRCasFinder	5895968-5895992	25	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	2699529-2699553	4	0.84
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP034351	Streptomyces sp. W1SF4 plasmid p1, complete sequence	165896-165922	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	503799-503825	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	485456-485482	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP030263	Ensifer adhaerens strain Corn53 plasmid AA, complete sequence	885852-885878	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021795	Sinorhizobium meliloti strain USDA1157 plasmid psymB, complete sequence	312337-312363	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP019484	Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence	1242736-1242762	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP019487	Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence	1015290-1015316	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3004848-3004874	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP011296	Rhodococcus erythropolis strain BG43 plasmid pRLCBG43, complete sequence	160445-160471	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP038636	Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence	521456-521482	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP012255	Cronobacter sakazakii strain NCTC 8155 plasmid pCS2, complete sequence	37873-37899	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP049260	Cronobacter sakazakii strain CS-931 plasmid pCsaCS931b, complete sequence	50105-50131	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_020263	Cronobacter sakazakii SP291 plasmid pSP291-1, complete sequence	51300-51326	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_019957	Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence	106294-106320	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP012267	Cronobacter dublinensis subsp. dublinensis LMG 23823 plasmid pCDU1, complete sequence	21890-21916	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	MT491207	Pseudomonas phage vB_PaeM_USP_18, complete genome	23547-23573	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	MT491208	Pseudomonas phage vB_PaeM_USP_25, complete genome	23504-23530	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	JN116828	Nocardia phage NBR1, complete genome	20100-20126	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	KF879863	UNVERIFIED: Nocardia phage NOC3, partial genome	18745-18771	5	0.815
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	MN857473	Teseptimavirus S2B, complete genome	7197-7223	5	0.815
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	542549-542579	6	0.806
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	364412-364442	6	0.806
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NC_008269	Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence	542549-542579	6	0.806
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	364412-364442	6	0.806
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_CP017076	Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence	360385-360415	6	0.806
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_LR134451	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence	34865-34891	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	243156-243182	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP029357	Azospirillum sp. CFH 70021 plasmid unnamed2	416405-416431	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_019849	Sinorhizobium meliloti GR4 plasmid pRmeGR4d, complete sequence	631065-631091	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP027296	Streptomyces sp. SGAir0924 plasmid unnamed_1, complete sequence	3078-3104	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP027298	Streptomyces sp. SGAir0924 plasmid unnamed_4, complete sequence	14212-14238	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_017326	Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence	619808-619834	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	17259-17285	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_017323	Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequence	216662-216688	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	JX469827	Uncultured bacterium plasmid pEMT3, complete sequence	14567-14593	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP009146	Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence	624771-624797	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_018701	Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence	617482-617508	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	JN106170	Uncultured bacterium plasmid pAKD25, complete sequence	12720-12746	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	JN106175	Uncultured bacterium plasmid pAKD34, complete sequence	12719-12745	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1795862-1795888	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	JN106167	Uncultured bacterium plasmid pAKD16, complete sequence	12719-12745	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP011665	Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence	240695-240721	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP015881	Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence	1287387-1287413	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	CP000662	Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence	266452-266478	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	447451-447477	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021802	Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence	1285419-1285445	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021820	Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence	973199-973225	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021814	Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence	541659-541685	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021810	Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence	1406273-1406299	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021218	Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence	771519-771545	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP026527	Sinorhizobium meliloti strain AK21 plasmid pSymB, complete sequence	641287-641313	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP015733	Arthrobacter sp. U41 plasmid unnamed1, complete sequence	22901-22927	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_003078	Sinorhizobium meliloti 1021 plasmid pSymB, complete sequence	1102147-1102173	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP019586	Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymB, complete sequence	1072638-1072664	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_013207	Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 plasmid pAACI02, complete sequence	77231-77257	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021799	Sinorhizobium meliloti strain USDA1106 plasmid psymB, complete sequence	1168370-1168396	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021828	Sinorhizobium meliloti strain KH35c plasmid psymB, complete sequence	672862-672888	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021823	Sinorhizobium meliloti strain KH46 plasmid psymB, complete sequence	789758-789784	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP021806	Sinorhizobium meliloti strain T073 plasmid psymB, complete sequence	390141-390167	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP054616	Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence	505352-505378	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_019318	Ralstonia pickettii plasmid p712, complete sequence	49947-49973	6	0.778
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NC_020560	Sinorhizobium meliloti 2011 plasmid pSymB, complete sequence	1102153-1102179	6	0.778
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	364413-364443	7	0.774
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_CP007130	Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence	110889-110919	7	0.774
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	516169-516199	7	0.774
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP020399	Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence	493493-493519	7	0.741
NZ_CP045178_7	7.1|3430098|27|NZ_CP045178|CRISPRCasFinder	3430098-3430124	27	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	723142-723168	7	0.741
NZ_CP045178_24	24.2|6374536|29|NZ_CP045178|CRISPRCasFinder	6374536-6374564	29	NC_023283	Streptomyces sp. FR1 plasmid pFRL3, complete sequence	206144-206172	7	0.759
NZ_CP045178_24	24.2|6374536|29|NZ_CP045178|CRISPRCasFinder	6374536-6374564	29	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1857412-1857440	7	0.759
NZ_CP045178_25	25.4|6879387|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT	6879387-6879419	33	NZ_CP032323	Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence	526705-526737	7	0.788
NZ_CP045178_29	29.4|8355911|34|NZ_CP045178|CRT	8355911-8355944	34	CP021131	Meiothermus taiwanensis strain WR-220 plasmid pMtWR-220, complete sequence	129924-129957	7	0.794
NZ_CP045178_29	29.5|8355965|34|NZ_CP045178|CRT	8355965-8355998	34	KC348600	Streptococcus phage phi5218, complete genome	14784-14817	7	0.794
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	323784-323814	8	0.742
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NZ_CP032328	Azospirillum brasilense strain MTCC4035 plasmid p7, complete sequence	143078-143108	8	0.742
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	323784-323814	8	0.742
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NZ_CP032328	Azospirillum brasilense strain MTCC4035 plasmid p7, complete sequence	143078-143108	8	0.742
NZ_CP045178_4	4.7|2006594|30|NZ_CP045178|CRT	2006594-2006623	30	NZ_CP026489	Streptomyces sp. 604F plasmid unnamed, complete sequence	15674-15703	8	0.733
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_CP022191	Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence	131608-131638	8	0.742
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NC_007959	Nitrobacter hamburgensis X14 plasmid 1, complete sequence	15508-15538	8	0.742
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_CP021355	Rhodococcus sp. S2-17 plasmid pRB98, complete sequence	682649-682679	8	0.742
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	MN234218	Gordonia phage Powerball, complete genome	29139-29169	8	0.742
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	MH155867	Gordonia phage Easley, complete genome	26946-26976	8	0.742
NZ_CP045178_11	11.4|4137539|30|NZ_CP045178|CRT	4137539-4137568	30	NZ_CP029986	Sphingomonas sp. FARSPH plasmid p01, complete sequence	51934-51963	8	0.733
NZ_CP045178_24	24.2|6374536|29|NZ_CP045178|CRISPRCasFinder	6374536-6374564	29	NC_023316	Streptomyces sp. 14R-10 plasmid pZL1, complete sequence	108596-108624	8	0.724
NZ_CP045178_24	24.2|6374536|29|NZ_CP045178|CRISPRCasFinder	6374536-6374564	29	NZ_CP029834	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence	272725-272753	8	0.724
NZ_CP045178_29	29.1|8355749|34|NZ_CP045178|CRT	8355749-8355782	34	CP021131	Meiothermus taiwanensis strain WR-220 plasmid pMtWR-220, complete sequence	129924-129957	8	0.765
NZ_CP045178_29	29.5|8355965|34|NZ_CP045178|CRT	8355965-8355998	34	NZ_CP010801	Ralstonia mannitolilytica strain SN82F48 plasmid pRMAN01, complete sequence	125373-125406	8	0.765
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	20957-20987	9	0.71
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NC_007766	Rhizobium etli CFN 42 plasmid p42f, complete sequence	449928-449958	9	0.71
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	12135-12165	9	0.71
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1842840-1842870	9	0.71
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1112118-1112148	9	0.71
NZ_CP045178_4	4.3|2006393|31|NZ_CP045178|CRT	2006393-2006423	31	NC_022049	Paracoccus aminophilus JCM 7686 plasmid pAMI4, complete sequence	154138-154168	9	0.71
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	20957-20987	9	0.71
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NC_007766	Rhizobium etli CFN 42 plasmid p42f, complete sequence	449928-449958	9	0.71
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	12135-12165	9	0.71
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1842840-1842870	9	0.71
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1112118-1112148	9	0.71
NZ_CP045178_4	4.6|2006542|31|NZ_CP045178|CRT	2006542-2006572	31	NC_022049	Paracoccus aminophilus JCM 7686 plasmid pAMI4, complete sequence	154138-154168	9	0.71
NZ_CP045178_11	11.4|4137539|30|NZ_CP045178|CRT	4137539-4137568	30	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	1186262-1186291	9	0.7
NZ_CP045178_25	25.4|6879387|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT	6879387-6879419	33	LR134125	Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 5	34224-34256	9	0.727
NZ_CP045178_29	29.3|8355857|34|NZ_CP045178|CRT	8355857-8355890	34	NC_047962	Xanthomonas phage Carpasina, complete genome	43511-43544	9	0.735
NZ_CP045178_29	29.3|8355857|34|NZ_CP045178|CRT	8355857-8355890	34	MH191395	Xanthomonas virus XcP1, complete genome	43713-43746	9	0.735
NZ_CP045178_29	29.3|8355857|34|NZ_CP045178|CRT	8355857-8355890	34	JQ680375	Unidentified phage clone 2209_scaffold2350 genomic sequence	18822-18855	9	0.735
NZ_CP045178_29	29.6|8356019|34|NZ_CP045178|CRT	8356019-8356052	34	NZ_CP023993	Streptomyces malaysiensis strain DSM 4137 plasmid unnamed, complete sequence	5492-5525	9	0.735
NZ_CP045178_29	29.6|8356019|34|NZ_CP045178|CRT	8356019-8356052	34	NZ_CP044072	Pseudomonas oryzihabitans strain FDAARGOS_657 plasmid unnamed1, complete sequence	39313-39346	9	0.735
NZ_CP045178_4	4.7|2006594|30|NZ_CP045178|CRT	2006594-2006623	30	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	323784-323813	10	0.667
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_CP016500	Agrobacterium sp. RAC06 plasmid pBSY240_1, complete sequence	13060-13090	10	0.677
NZ_CP045178_4	4.11|2006828|31|NZ_CP045178|CRT	2006828-2006858	31	NZ_CP045856	Agrobacterium sp. MA01 plasmid punanmed2, complete sequence	88177-88207	10	0.677
NZ_CP045178_25	25.1|6879204|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT	6879204-6879236	33	NZ_LR134465	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence	382448-382480	10	0.697
NZ_CP045178_29	29.3|8355857|34|NZ_CP045178|CRT	8355857-8355890	34	AJ567472	Acidianus filamentus virus 1 complete genome	10107-10140	10	0.706

1. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP020399 (Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence) position: , mismatch: 2, identity: 0.926

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgaggcgaccgacgcggtggcc	Protospacer
******* ****.**************

2. spacer 4.8|2006645|25|NZ_CP045178|CRT matches to NZ_CP015585 (Roseomonas gilardii strain U14-5 plasmid 1, complete sequence) position: , mismatch: 3, identity: 0.88

ggcgcgaggaccttgccccgcacgg	CRISPR spacer
cgcgcgaggacctcgcccggcacgg	Protospacer
 ************.**** ******

3. spacer 4.8|2006645|25|NZ_CP045178|CRT matches to NZ_CP024587 (Roseomonas sp. FDAARGOS_362 plasmid unnamed3, complete sequence) position: , mismatch: 3, identity: 0.88

ggcgcgaggaccttgccccgcacgg	CRISPR spacer
cgcgcgaggacctcgcccggcacgg	Protospacer
 ************.**** ******

4. spacer 6.2|2947541|25|NZ_CP045178|CRISPRCasFinder matches to NZ_CP017076 (Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence) position: , mismatch: 3, identity: 0.88

tcaggggcccttgccccgccgtgcc	CRISPR spacer
gcaggagcccttgccccgccgtgcg	Protospacer
 ****.****************** 

5. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP018075 (Streptomyces venezuelae strain NRRL B-65442 plasmid, complete sequence) position: , mismatch: 3, identity: 0.889

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gccgccgcggcggccgccgcggtggcc	Protospacer
 ******.******** **********

6. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 3, identity: 0.889

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gccgccgtggaggccgaggcggtggcc	Protospacer
 ********* ****** *********

7. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP012399 (Chelatococcus sp. CO-6 plasmid pCO-6, complete sequence) position: , mismatch: 3, identity: 0.889

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gccgccgtggaggccgaggcggtggcc	Protospacer
 ********* ****** *********

8. spacer 6.1|2947487|28|NZ_CP045178|CRISPRCasFinder matches to NC_015065 (Granulicella tundricola MP5ACTX9 plasmid pACIX902, complete sequence) position: , mismatch: 4, identity: 0.857

catgctcggaaccaccggtctgcaccgg	CRISPR spacer
gatgctcggaaccgccgatctgcaccag	Protospacer
 ************.***.********.*

9. spacer 6.2|2947541|25|NZ_CP045178|CRISPRCasFinder matches to MK416019 (Klebsiella phage ST11-VIM1phi8.3, complete genome) position: , mismatch: 4, identity: 0.84

tcaggggcccttgccccgccgtgcc	CRISPR spacer
tcaggcgcccttgccccgccttgag	Protospacer
***** ************** **  

10. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_010333 (Caulobacter sp. K31 plasmid pCAUL02, complete sequence) position: , mismatch: 4, identity: 0.852

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggccgccgcggtgttg	Protospacer
**************** ******* . 

11. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 4, identity: 0.852

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
ctccccgtgccggccggcgcggtggcc	Protospacer
*.* ***** ******.**********

12. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 4, identity: 0.852

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
ctcgccgtggcggccgtcgcggcggtc	Protospacer
*.************** *****.**.*

13. spacer 20.1|5895968|25|NZ_CP045178|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 4, identity: 0.84

ccgagccccagtgcggtcagtgcct	CRISPR spacer
ccgagccccagtgcagtcactgcgc	Protospacer
**************.**** *** .

14. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP034351 (Streptomyces sp. W1SF4 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gccgccgtggccgccgacgcggtgaaa	Protospacer
 ********** ************.  

15. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gacgccgtggccgccgacgcgctggac	Protospacer
  ********* ********* *** *

16. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccctggcggccgacccggtgaag	Protospacer
****** *********** *****.  

17. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP030263 (Ensifer adhaerens strain Corn53 plasmid AA, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cgggccgtggcggccgacggggtggtg	Protospacer
*  **************** *****. 

18. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021795 (Sinorhizobium meliloti strain USDA1157 plasmid psymB, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtgtga	Protospacer
*************.** *******   

19. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP019484 (Sinorhizobium meliloti strain B401 plasmid pSymB, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtgtga	Protospacer
*************.** *******   

20. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP019487 (Sinorhizobium meliloti strain B399 plasmid pSym, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtgtga	Protospacer
*************.** *******   

21. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgaggcggccgacgcgaagccg	Protospacer
******* *************. * * 

22. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP011296 (Rhodococcus erythropolis strain BG43 plasmid pRLCBG43, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gcaaccggggcggccggcgcggtggcc	Protospacer
 * .*** ********.**********

23. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP038636 (Cupriavidus oxalaticus strain X32 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggcctgcgcggttatc	Protospacer
*************** .****** ..*

24. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP012255 (Cronobacter sakazakii strain NCTC 8155 plasmid pCS2, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cacgccgtggcggccgatgcgctggat	Protospacer
* ***************.*** *** .

25. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP049260 (Cronobacter sakazakii strain CS-931 plasmid pCsaCS931b, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cacgccgtggcggccgatgcgctggat	Protospacer
* ***************.*** *** .

26. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_020263 (Cronobacter sakazakii SP291 plasmid pSP291-1, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cacgccgtggcggccgatgcgctggat	Protospacer
* ***************.*** *** .

27. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_019957 (Mycobacterium sp. JS623 plasmid pMYCSM01, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gccgccgtggcggccgccgcggggcgc	Protospacer
 *************** ***** *  *

28. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP012267 (Cronobacter dublinensis subsp. dublinensis LMG 23823 plasmid pCDU1, complete sequence) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cacgccgtggcggcggacgcgctggat	Protospacer
* ************ ****** *** .

29. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to MT491207 (Pseudomonas phage vB_PaeM_USP_18, complete genome) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
accgccgtcgcggccgacgaggtgatc	Protospacer
 ******* ********** ****..*

30. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to MT491208 (Pseudomonas phage vB_PaeM_USP_25, complete genome) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
accgccgtcgcggccgacgaggtgatc	Protospacer
 ******* ********** ****..*

31. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to JN116828 (Nocardia phage NBR1, complete genome) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
ttcaccgtggaggacgacgcggtggcc	Protospacer
..*.****** ** *************

32. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to KF879863 (UNVERIFIED: Nocardia phage NOC3, partial genome) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
ttcaccgtggaggacgacgcggtggcc	Protospacer
..*.****** ** *************

33. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to MN857473 (Teseptimavirus S2B, complete genome) position: , mismatch: 5, identity: 0.815

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
tcggccgtggtggccgacgcggcggcg	Protospacer
.* *******.***********.*** 

34. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 6, identity: 0.806

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
caggccggtgaccagaccggcgcgaccgccc	Protospacer
* ** *******************. * **.

35. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
cccgacggcgaccagaccggcgcgccgcccg	Protospacer
** *****.***************   *** 

36. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NC_008269 (Rhodococcus jostii RHA1 plasmid pRHL1, complete sequence) position: , mismatch: 6, identity: 0.806

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
caggccggtgaccagaccggcgcgaccgccc	Protospacer
* ** *******************. * **.

37. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
cccgacggcgaccagaccggcgcgccgcccg	Protospacer
** *****.***************   *** 

38. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_CP017076 (Novosphingobium resinovorum strain SA1 plasmid pSA1, complete sequence) position: , mismatch: 6, identity: 0.806

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
ggcacggcgaccagaccgacgcgctcgccat	Protospacer
*******.**********.*****   ** *

39. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_LR134451 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 9, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gtcgccgcggcggccgtcgcggtgggt	Protospacer
 .*****.******** ******** .

40. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cgcgccgtggcggcagacgcggtacag	Protospacer
* ************ ********.   

41. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP029357 (Azospirillum sp. CFH 70021 plasmid unnamed2) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
aaggccgaggcggccgaggcggtggcg	Protospacer
   **** ********* ******** 

42. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_019849 (Sinorhizobium meliloti GR4 plasmid pRmeGR4d, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

43. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP027296 (Streptomyces sp. SGAir0924 plasmid unnamed_1, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacg-cggtggcc	CRISPR spacer
tccgccgtggcggccgacgccagcagt-	Protospacer
.****************** *.*..*. 

44. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP027298 (Streptomyces sp. SGAir0924 plasmid unnamed_4, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacg-cggtggcc	CRISPR spacer
tccgccgtggcggccgacgccagcagt-	Protospacer
.****************** *.*..*. 

45. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_017326 (Sinorhizobium meliloti SM11 plasmid pSmeSM11d, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

46. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cttcaggtcgcggccgacgcggtggcc	Protospacer
*..   ** ******************

47. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_017323 (Sinorhizobium meliloti BL225C plasmid pSINMEB02, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

48. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to JX469827 (Uncultured bacterium plasmid pEMT3, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccttggcggccgacgcgaggaag	Protospacer
****** **************. *.  

49. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP009146 (Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

50. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_018701 (Sinorhizobium meliloti Rm41 plasmid pSYMB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

51. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to JN106170 (Uncultured bacterium plasmid pAKD25, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccttggcggccgacgcgaggaag	Protospacer
****** **************. *.  

52. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to JN106175 (Uncultured bacterium plasmid pAKD34, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccttggcggccgacgcgaggaag	Protospacer
****** **************. *.  

53. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cttcaggtcgcggccgacgcggtggcc	Protospacer
*..   ** ******************

54. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to JN106167 (Uncultured bacterium plasmid pAKD16, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccttggcggccgacgcgaggaag	Protospacer
****** **************. *.  

55. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP011665 (Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
tccgccgtggtggccgacggggtgtgg	Protospacer
.*********.******** ****   

56. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP015881 (Ensifer adhaerens strain Casida A plasmid pCasidaAA, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cggtccgtggcggccgacggggtggtg	Protospacer
*   *************** *****. 

57. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to CP000662 (Rhodobacter sphaeroides ATCC 17025 plasmid pRSPA01, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
accgccgaggcggccgccgcggtgcgg	Protospacer
 ****** ******** *******   

58. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
tccgccgtggtggccgacggggtgtgg	Protospacer
.*********.******** ****   

59. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021802 (Sinorhizobium meliloti strain USDA1021 plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

60. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021820 (Sinorhizobium meliloti strain M162 plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

61. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021814 (Sinorhizobium meliloti strain M270 plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

62. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021810 (Sinorhizobium meliloti strain Rm41 plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

63. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021218 (Sinorhizobium meliloti RU11/001 plasmid pSymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

64. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP026527 (Sinorhizobium meliloti strain AK21 plasmid pSymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

65. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP015733 (Arthrobacter sp. U41 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
tgggccgtggcggccgacccggtgcac	Protospacer
.  *************** *****  *

66. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_003078 (Sinorhizobium meliloti 1021 plasmid pSymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

67. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP019586 (Sinorhizobium meliloti strain CCMM B554 (FSM-MA) plasmid pSymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

68. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_013207 (Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 plasmid pAACI02, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
ggggccgtggcggtcgacgcggaggcg	Protospacer
   **********.******** *** 

69. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021799 (Sinorhizobium meliloti strain USDA1106 plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

70. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021828 (Sinorhizobium meliloti strain KH35c plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

71. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021823 (Sinorhizobium meliloti strain KH46 plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

72. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP021806 (Sinorhizobium meliloti strain T073 plasmid psymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

73. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP054616 (Azospirillum oryzae strain KACC 14407 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gacgacgtggcggccgacgcggcggtg	Protospacer
  ** *****************.**. 

74. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_019318 (Ralstonia pickettii plasmid p712, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccttggcggccgacgcgaggaag	Protospacer
****** **************. *.  

75. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NC_020560 (Sinorhizobium meliloti 2011 plasmid pSymB, complete sequence) position: , mismatch: 6, identity: 0.778

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
cccgccgtggcggtcgccgcggtatga	Protospacer
*************.** ******.   

76. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.774

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
ccgacggcgaccagaccggcgcgccgcccgc	Protospacer
   ****.**************** **** .

77. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_CP007130 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 2, complete sequence) position: , mismatch: 7, identity: 0.774

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
accgtggtgagcggaccggcgcgcggccctc	Protospacer
. *..***** *.*****************.

78. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 7, identity: 0.774

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
accaccgtgaccagaccggcccgcggcgccc	Protospacer
. *** ************** ****** *..

79. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP020399 (Burkholderia multivorans strain FDAARGOS_246 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.741

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
ggcgccgtcgcggccgacgcggtcttt	Protospacer
  ****** **************  ..

80. spacer 7.1|3430098|27|NZ_CP045178|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.741

cccgccgtggcggccgacgcggtggcc	CRISPR spacer
gccgccgtggccgccgacgcggaacgg	Protospacer
 ********** ********** .   

81. spacer 24.2|6374536|29|NZ_CP045178|CRISPRCasFinder matches to NC_023283 (Streptomyces sp. FR1 plasmid pFRL3, complete sequence) position: , mismatch: 7, identity: 0.759

gcgccccgcccggaggaggccgtcacccc	CRISPR spacer
acgccccgcccggacgagcccgtcgtcaa	Protospacer
.************* *** *****..*  

82. spacer 24.2|6374536|29|NZ_CP045178|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 7, identity: 0.759

gcgccccgcccggaggaggccgtcacccc	CRISPR spacer
gggggaagctcggaggaggccgtcacccg	Protospacer
* *    **.****************** 

83. spacer 25.4|6879387|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032323 (Azospirillum brasilense strain MTCC4035 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.788

gaggacgccgttggtgtcgccggcgtacggctg--	CRISPR spacer
caggacgccgttcgtgttgccggcg--cgggtaac	Protospacer
 *********** ****.*******  *** *.  

84. spacer 29.4|8355911|34|NZ_CP045178|CRT matches to CP021131 (Meiothermus taiwanensis strain WR-220 plasmid pMtWR-220, complete sequence) position: , mismatch: 7, identity: 0.794

ccggcagcgggaggaggacaagaaataccaggag	CRISPR spacer
caggttgcgggagggggaaaagaaataccagcaa	Protospacer
* **. ********.*** ************ *.

85. spacer 29.5|8355965|34|NZ_CP045178|CRT matches to KC348600 (Streptococcus phage phi5218, complete genome) position: , mismatch: 7, identity: 0.794

gggtgaacag-gacgaggcgaagaaactccaggag	CRISPR spacer
-gttgctcggtgacgaagcgaagaaactcaaggag	Protospacer
 * **  *.* *****.************ *****

86. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 8, identity: 0.742

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gtcggcggggaccagaccggcgcgggcggcc	Protospacer
 . *.*** ******************  *.

87. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NZ_CP032328 (Azospirillum brasilense strain MTCC4035 plasmid p7, complete sequence) position: , mismatch: 8, identity: 0.742

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
ctccccggtgaccagggcggcgcgggccggt	Protospacer
*.   **********. ***********  *

88. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 8, identity: 0.742

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gtcggcggggaccagaccggcgcgggcggcc	Protospacer
 . *.*** ******************  *.

89. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NZ_CP032328 (Azospirillum brasilense strain MTCC4035 plasmid p7, complete sequence) position: , mismatch: 8, identity: 0.742

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
ctccccggtgaccagggcggcgcgggccggt	Protospacer
*.   **********. ***********  *

90. spacer 4.7|2006594|30|NZ_CP045178|CRT matches to NZ_CP026489 (Streptomyces sp. 604F plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

ggcatggggaccagaccggcacgggccctt	CRISPR spacer
acgatgcggaccagaccggcaccggcgttg	Protospacer
.  *** *************** *** .* 

91. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_CP022191 (Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.742

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
ctcacggtgagcagagcggcgcgcggcatcg	Protospacer
  ******** **** *********** .. 

92. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NC_007959 (Nitrobacter hamburgensis X14 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.742

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
tcgacggcgaccagaccgccgcgcggctgtc	Protospacer
   ****.********** ********. *.

93. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_CP021355 (Rhodococcus sp. S2-17 plasmid pRB98, complete sequence) position: , mismatch: 8, identity: 0.742

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
gccactgtgaccagagcggcgcgcgcggcca	Protospacer
* *** ********* *********   *. 

94. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to MN234218 (Gordonia phage Powerball, complete genome) position: , mismatch: 8, identity: 0.742

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
ggcacggcgaccagactggcgcgattggttt	Protospacer
*******.********.******     .**

95. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to MH155867 (Gordonia phage Easley, complete genome) position: , mismatch: 8, identity: 0.742

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
ggcacggcgaccagactggcgcgattggttt	Protospacer
*******.********.******     .**

96. spacer 11.4|4137539|30|NZ_CP045178|CRT matches to NZ_CP029986 (Sphingomonas sp. FARSPH plasmid p01, complete sequence) position: , mismatch: 8, identity: 0.733

agcactgtcggaagcgcgggcgcgaacacg	CRISPR spacer
ggcactggcggaagcgcgggcggctgaact	Protospacer
.****** **************   . ** 

97. spacer 24.2|6374536|29|NZ_CP045178|CRISPRCasFinder matches to NC_023316 (Streptomyces sp. 14R-10 plasmid pZL1, complete sequence) position: , mismatch: 8, identity: 0.724

gcgccccgcccggaggaggccgtcacccc	CRISPR spacer
cgaagcttcccggaggaggccgccacccc	Protospacer
  .  *. **************.******

98. spacer 24.2|6374536|29|NZ_CP045178|CRISPRCasFinder matches to NZ_CP029834 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed4, complete sequence) position: , mismatch: 8, identity: 0.724

gcgccccgcccggaggaggccgtcacccc	CRISPR spacer
ctctaccggccggaggaggacgtcaccct	Protospacer
 . . *** ********** ********.

99. spacer 29.1|8355749|34|NZ_CP045178|CRT matches to CP021131 (Meiothermus taiwanensis strain WR-220 plasmid pMtWR-220, complete sequence) position: , mismatch: 8, identity: 0.765

ccagcagcgggaggaggacaagaaataccaggag	CRISPR spacer
caggttgcgggagggggaaaagaaataccagcaa	Protospacer
* .*. ********.*** ************ *.

100. spacer 29.5|8355965|34|NZ_CP045178|CRT matches to NZ_CP010801 (Ralstonia mannitolilytica strain SN82F48 plasmid pRMAN01, complete sequence) position: , mismatch: 8, identity: 0.765

gggtgaacaggacgaggcgaagaaactccaggag	CRISPR spacer
gcagcaacaggacgaggcgaaaaagctccagacg	Protospacer
* .  ****************.**.******. *

101. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgttg	Protospacer
  .**** ********.********** .. 

102. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NC_007766 (Rhizobium etli CFN 42 plasmid p42f, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gttgacggtgaccaggccggcgcggatgtcg	Protospacer
 . ************.*********.. .* 

103. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgtta	Protospacer
  .**** ********.********** .. 

104. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgtta	Protospacer
  .**** ********.********** .. 

105. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgttg	Protospacer
  .**** ********.********** .. 

106. spacer 4.3|2006393|31|NZ_CP045178|CRT matches to NC_022049 (Paracoccus aminophilus JCM 7686 plasmid pAMI4, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gcattcgatgaccagatcggcgcgggccagc	Protospacer
 *.  **.********.***********  .

107. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgttg	Protospacer
  .**** ********.********** .. 

108. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NC_007766 (Rhizobium etli CFN 42 plasmid p42f, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gttgacggtgaccaggccggcgcggatgtcg	Protospacer
 . ************.*********.. .* 

109. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgtta	Protospacer
  .**** ********.********** .. 

110. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgtta	Protospacer
  .**** ********.********** .. 

111. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gaagacgctgaccagatcggcgcgggcgttg	Protospacer
  .**** ********.********** .. 

112. spacer 4.6|2006542|31|NZ_CP045178|CRT matches to NC_022049 (Paracoccus aminophilus JCM 7686 plasmid pAMI4, complete sequence) position: , mismatch: 9, identity: 0.71

ccggacggtgaccagaccggcgcgggcccct	CRISPR spacer
gcattcgatgaccagatcggcgcgggccagc	Protospacer
 *.  **.********.***********  .

113. spacer 11.4|4137539|30|NZ_CP045178|CRT matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.7

agcactgtcggaagcgcgggcgcgaacacg	CRISPR spacer
tcgttcatcggcaacgcgggcgcgaacacg	Protospacer
    ...**** *.****************

114. spacer 25.4|6879387|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT matches to LR134125 (Klebsiella aerogenes strain NCTC10006 genome assembly, plasmid: 5) position: , mismatch: 9, identity: 0.727

gaggacgccgttggtgtcgccggcgtacggctg	CRISPR spacer
atgaaaaccgtaagtgtcgccggcgtacggcct	Protospacer
. *.* .**** .******************. 

115. spacer 29.3|8355857|34|NZ_CP045178|CRT matches to NC_047962 (Xanthomonas phage Carpasina, complete genome) position: , mismatch: 9, identity: 0.735

ggccgaacaggaagaggccaagaaacaggcggac	CRISPR spacer
actcgccaaggaagaggccaagaagctggcggaa	Protospacer
. .**   ****************.* ****** 

116. spacer 29.3|8355857|34|NZ_CP045178|CRT matches to MH191395 (Xanthomonas virus XcP1, complete genome) position: , mismatch: 9, identity: 0.735

ggccgaacaggaagaggccaagaaacaggcggac	CRISPR spacer
gctggcgaaggaagaggccaagaagctggcggaa	Protospacer
* . * . ****************.* ****** 

117. spacer 29.3|8355857|34|NZ_CP045178|CRT matches to JQ680375 (Unidentified phage clone 2209_scaffold2350 genomic sequence) position: , mismatch: 9, identity: 0.735

ggccgaacaggaagaggccaagaaacaggcggac	CRISPR spacer
gcaagcctatgaggacgccaagaaacaggcggac	Protospacer
*   *  .* **.** ******************

118. spacer 29.6|8356019|34|NZ_CP045178|CRT matches to NZ_CP023993 (Streptomyces malaysiensis strain DSM 4137 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.735

ccagcagcgggacgaggaccgcaagtaccaggac	CRISPR spacer
ccagcagctggacgaggcccgcaagcccatcgtg	Protospacer
******** ******** *******. *   *  

119. spacer 29.6|8356019|34|NZ_CP045178|CRT matches to NZ_CP044072 (Pseudomonas oryzihabitans strain FDAARGOS_657 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.735

ccagcagcgggacgaggaccgcaagtaccaggac	CRISPR spacer
gaagctgcgggatgaggaccgcaagttcgacaag	Protospacer
  *** ******.************* * * .* 

120. spacer 4.7|2006594|30|NZ_CP045178|CRT matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 10, identity: 0.667

ggcatggggaccagaccggcacgggccctt	CRISPR spacer
tcggcggggaccagaccggcgcgggcggcc	Protospacer
   ..***************.*****  ..

121. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_CP016500 (Agrobacterium sp. RAC06 plasmid pBSY240_1, complete sequence) position: , mismatch: 10, identity: 0.677

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
acagtggtgaccggaccggcgctcggcctcg	Protospacer
.  ..*******.********* *****.. 

122. spacer 4.11|2006828|31|NZ_CP045178|CRT matches to NZ_CP045856 (Agrobacterium sp. MA01 plasmid punanmed2, complete sequence) position: , mismatch: 10, identity: 0.677

ggcacggtgaccagaccggcgcgcggccctt	CRISPR spacer
acagtggtgaccggaccggcgctcggcctcg	Protospacer
.  ..*******.********* *****.. 

123. spacer 25.1|6879204|33|NZ_CP045178|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR134465 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 23, complete sequence) position: , mismatch: 10, identity: 0.697

gttctccagccgggcgttgcggatcttggcgcg	CRISPR spacer
cgtctcgagccaggcgttgcggatctcccggtc	Protospacer
  **** ****.**************.   *. 

124. spacer 29.3|8355857|34|NZ_CP045178|CRT matches to AJ567472 (Acidianus filamentus virus 1 complete genome) position: , mismatch: 10, identity: 0.706

ggccgaacaggaagaggccaagaaacaggcggac	CRISPR spacer
agtagaacaggaataagccaagaaacagcacaaa	Protospacer
.*. ********* *.************   .*