CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number
NZ_CP045327	Mycobacterium sp. THAF192 plasmid pTHAF192_b, complete sequence	0 crisprs	NA	0	0	8
NZ_CP045325	Mycobacterium sp. THAF192 chromosome, complete genome	6 crisprs	WYL,PD-DExK,cas3,csa3,c2c9_V-U4,casR,cas4,DEDDh,DinG	3	3	3
NZ_CP045326	Mycobacterium sp. THAF192 plasmid pTHAF192_a, complete sequence	0 crisprs	csf3gr5,csf2gr7,csf4gr11,csf1gr8	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 16628

Mycobacterium_phage(80.0%)

protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152520122.1\|3588_4014_+	XRE family transcriptional regulator	NA	NA	NA	NA
WP_094295050.1\|4185_4485_+	PE domain-containing protein	NA	NA	NA	NA
WP_152520123.1\|4489_5848_+	PPE domain-containing protein	NA	NA	NA	NA
WP_152520124.1\|5926_6229_+	hypothetical protein	NA	NA	NA	NA
WP_152520125.1\|6266_6560_+	hypothetical protein	NA	NA	NA	NA
WP_152520126.1\|6574_7531_+	ESX secretion-associated protein EspG	NA	NA	NA	NA
WP_152520127.1\|8456_9473_+	AAA family ATPase	V5UPR8	Mycobacterium_phage	1.1e-33	34.9
WP_152520128.1\|9469_10987_+	type VII secretion integral membrane protein EccD	V5UN55	Mycobacterium_phage	3.5e-15	27.2
WP_152520129.1\|10983_12648_+\|protease	type VII secretion-associated serine protease mycosin	V5UPA7	Mycobacterium_phage	1.9e-62	35.9
WP_152520130.1\|12644_14192_+	type VII secretion protein EccE	NA	NA	NA	NA
WP_152520131.1\|14536_15322_-	hypothetical protein	NA	NA	NA	NA
WP_152520132.1\|15484_16264_-	hypothetical protein	V5UQM8	Mycobacterium_phage	3.7e-16	34.1
WP_094295600.1\|16253_16628_-	helix-turn-helix transcriptional regulator	Q854V2	Mycobacterium_virus	1.1e-05	38.8

DBSCAN-SWA_2

24685 : 30247

Bacillus_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152520138.1\|24685_26476_+	AAA family ATPase	G3MAX6	Bacillus_virus	6.0e-30	30.7
WP_152520139.1\|26478_27129_+	hypothetical protein	NA	NA	NA	NA
WP_152520140.1\|27213_28761_+	protein kinase	A0A0B5J6A8	Pandoravirus	3.7e-12	27.8
WP_152520141.1\|28825_30247_-	TraM recognition domain-containing protein	V5UN59	Mycobacterium_phage	7.9e-17	37.1

DBSCAN-SWA_3

39291 : 43208

Mycobacterium_phage(50.0%)

integrase

attL 41089:41102|attR 46845:46858

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152520146.1\|39291_39537_-	glutaredoxin-like protein NrdH	V5UN81	Mycobacterium_phage	1.3e-20	63.3
41089:41102	attL	NA	NA	NA	NA
WP_152520147.1\|41484_42186_+	hypothetical protein	NA	NA	NA	NA
WP_152520148.1\|42182_43208_+\|integrase	tyrosine-type recombinase/integrase	A0A2I6UG75	Salinibacter_virus	2.9e-05	25.9
46845:46858	attR	NA	NA	NA	NA

DBSCAN-SWA_4

58118 : 59552

Moraxella_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152520162.1\|58118_59552_-	hypothetical protein	A0A0R6PHV4	Moraxella_phage	1.1e-26	27.1

DBSCAN-SWA_5

67863 : 68832

Sinorhizobium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152520168.1\|67863_68832_-	DNA ligase	A0A291AUP8	Sinorhizobium_phage	4.0e-44	37.5

DBSCAN-SWA_6

76390 : 86454

Mycobacterium_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152520173.1\|76390_77155_+	thermonuclease family protein	V5UN65	Mycobacterium_phage	9.1e-36	50.9
WP_152520174.1\|77235_77823_+	hypothetical protein	NA	NA	NA	NA
WP_152520175.1\|77825_78401_+	hypothetical protein	V5UP84	Mycobacterium_phage	1.3e-07	32.1
WP_152520199.1\|78397_80197_+	hypothetical protein	NA	NA	NA	NA
WP_152520200.1\|80320_81151_+	DUF4226 domain-containing protein	NA	NA	NA	NA
WP_152520201.1\|81198_86454_-	DEAD/DEAH box helicase family protein	A0A248SL14	Klebsiella_phage	2.0e-198	31.4

DBSCAN-SWA_7

91037 : 97397

Mycobacterium_phage(75.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_173012291.1\|91037_92123_-	hypothetical protein	A0A142F2N0	Mycobacterium_phage	3.3e-23	43.9
WP_152520204.1\|92205_93114_-	C40 family peptidase	X5JAJ3	Clostridium_phage	1.1e-16	47.3
WP_152520182.1\|93318_94470_-	hypothetical protein	NA	NA	NA	NA
WP_152520183.1\|95330_96137_-	AAA family ATPase	V5UP47	Mycobacterium_phage	2.6e-57	44.6
WP_152520184.1\|96542_97397_+	DUF2637 domain-containing protein	A0A222YXY9	Mycobacterium_phage	6.0e-12	40.2

DBSCAN-SWA_8

105901 : 109954

Mycobacterium_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152520191.1\|105901_108346_+	hypothetical protein	V5UPQ7	Mycobacterium_phage	7.7e-20	30.1
WP_152520192.1\|108475_109954_+	type VII secretion protein EccB	V5UN45	Mycobacterium_phage	1.7e-70	36.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_CP045325

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_CP045325_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045325_3

216211-216288

Orphan

Consensus_repeat	Method
GCCACGGCGGTGCTCTCGTCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045325_3

>merge|NZ_CP045325|3|216211-216288|CRISPRCasFinder
GTCTCGGCGGTGTTGTCGTCGCCGTAGACGCTGGCGCGGCTGCCCGGTCCGTCGGCTCCGGCGGTGTTGTCGTCGCCG

>NZ_CP045325|3|3|216211-216288|CRISPRCasFinder
GTCTCGGCGGTGTTGTCGTCGCCG	TAGACGCTGGCGCGGCTGCCCGGTCCGTCG
GCTCCGGCGGTGTTGTCGTCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045325.1\|WP_152514988.1\|208381_209632_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_CP045325.1\|WP_152514997.1\|231048_232878_+\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NZ_CP045325.1\|WP_152514993.1\|223781_226754_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP045325.1\|WP_152514994.1\|226824_227541_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NZ_CP045325.1\|WP_152514984.1\|205431_205818_+\|hemophore-related-protein	unknown	unknown	gnl\|CDD\|374603
NZ_CP045325.1\|WP_152514995.1\|227537_228323_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP045325.1\|WP_152514989.1\|209650_210817_-\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|223469
NZ_CP045325.1\|WP_173012153.1\|205902_206571_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP045325.1\|WP_152519440.1\|228562_229483_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|206686
NZ_CP045325.1\|WP_152514998.1\|233044_233275_+\|antitoxin	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514986.1\|206586_207942_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP045325.1\|WP_152514990.1\|210894_212046_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|279875
NZ_CP045325.1\|WP_152519441.1\|233261_233609_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP045325.1\|WP_152514981.1\|201014_201506_-\|XRE-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514999.1\|233710_235234_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236215
NZ_CP045325.1\|WP_152514982.1\|201502_204430_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP045325.1\|WP_152514996.1\|229488_230853_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514987.1\|208026_208395_-\|DUF3054-family-protein	unknown	unknown	gnl\|CDD\|378616
NZ_CP045325.1\|WP_152514992.1\|217606_223588_-\|tandem-95-repeat-protein	unknown	unknown	gnl\|CDD\|225926
NZ_CP045325.1\|WP_152514983.1\|204696_205242_+\|hemophore	unknown	unknown	gnl\|CDD\|275323

Protein	Function_ID	Function_description	E-value
NZ_CP045325.1\|WP_152514988.1\|208381_209632_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.74365e-14
NZ_CP045325.1\|WP_152514993.1\|223781_226754_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.77834e-138
NZ_CP045325.1\|WP_152514994.1\|226824_227541_-\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.22829e-06
NZ_CP045325.1\|WP_152514984.1\|205431_205818_+\|hemophore-related-protein	gnl\|CDD\|374603	pfam16525, MHB, Haemophore, haem-binding. MHB is a coiled-coil molecule that binds free haem in mycobacterial cytoplasm to deliver it to membrane proteins for shuttling through the membrane.	3.5727e-37
NZ_CP045325.1\|WP_152514995.1\|227537_228323_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	1.26748e-86
NZ_CP045325.1\|WP_152514989.1\|209650_210817_-\|flippase-like-domain-containing-protein	gnl\|CDD\|223469	COG0392, COG0392, Predicted integral membrane protein [Function unknown].	2.61037e-43
NZ_CP045325.1\|WP_173012153.1\|205902_206571_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.48516e-81
NZ_CP045325.1\|WP_152519440.1\|228562_229483_+\|hypothetical-protein	gnl\|CDD\|206686	cd01899, Ygr210, Ygr210 GTPase. Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.	0.0017184
NZ_CP045325.1\|WP_152519441.1\|233261_233609_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	8.03134e-32
NZ_CP045325.1\|WP_152514986.1\|206586_207942_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.00981e-43
NZ_CP045325.1\|WP_152514990.1\|210894_212046_+\|AI-2E-family-transporter	gnl\|CDD\|279875	pfam01594, AI-2E_transport, AI-2E family transporter. This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.	1.84455e-57
NZ_CP045325.1\|WP_152514999.1\|233710_235234_+\|AMP-binding-protein	gnl\|CDD\|236215	PRK08276, PRK08276, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP045325.1\|WP_152514982.1\|201502_204430_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	4.65724e-136
NZ_CP045325.1\|WP_152514997.1\|231048_232878_+\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP045325.1\|WP_152514987.1\|208026_208395_-\|DUF3054-family-protein	gnl\|CDD\|378616	pfam11255, DUF3054, Protein of unknown function (DUF3054). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	9.33774e-25
NZ_CP045325.1\|WP_152514992.1\|217606_223588_-\|tandem-95-repeat-protein	gnl\|CDD\|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	7.26178e-22
NZ_CP045325.1\|WP_152514983.1\|204696_205242_+\|hemophore	gnl\|CDD\|275323	TIGR04530, hemophoreRv0203, hemophore, mycobacterial-type. Members of this family, including Rv0203 from Mycobacterium tuberculosis, are secreted heme-binding proteins used in heme acquisition. Such proteins are called hemophores. Members have a cleavable N-terminal signal peptide, and a mature region just over 100 amino acids long with a pair of invariant Cys residues. An unrelated hemophore, HasA, occurs in Gram-negative pathogens such as Yersinia pestis. [Transport and binding proteins, Other].	1.59488e-40

>NZ_CP045325.1|WP_152514990.1|210894_212046_+|AI-2E-family-transporter
MSAGPSLDPLADESVTPLVRKTAAWAWRLLIILAAVVALGWLILRLEILFVPVALATIVAALLMPVVDFLDRRGAPRSGAVALVLLSGFAVFGGLLAFVITQFIEGVPALAGQVSTSIEGVGAWLTDGPLKVSEQQINQFRDSALEALRDNQERLTSGAVSTAATVTEIVTGALLMLFTLIFLLYGGRNIFTFVTGVVPTGVRARVRNAGRAGFHTLIGYVRATFLVAAVDATGIGLGLAIMGVPLALPLASLVFMGAFVPLVGAVVTGFLAVIVALIAKGWIYALITLGLIIAVQQLEGHVLQPLVMGRAVSIHPLAIVLAIAGGAVLAGIVGALLAVPVLAFLNSAVRVLLADDPVAEEEAQEADDAPVIEAEPDDVEQLE
>NZ_CP045325.1|WP_152514989.1|209650_210817_-|flippase-like-domain-containing-protein
MSHDAPASGSPAGAANPERSRGKYWWLRWALIALALVVLTVELALVHDQLAKAWKSLYSANWMWVLAAVVAAMASMHSFAQIQRTLLRSAGVHVHQWRSEAAFYAGNALSTTMPGGPVLSATFIYRQQRMWGASPVVASWQLVMSGALQVIGLALLGLGGAFMLGASKNPLSLIFSLGGFVALILLAQAVASRPELIDGIGVRLLSWFNSVRGKPADTGLTKWRATLVQLESVQLGRRDLGEAFSWSLFNWVADVGCLLFACYATGGHPSVAGVTVAYAAARAVGSIPLMPGGLLVVEAVLVPGLVSSGMSLASAISAMLIYRLVSWIFIAAIGWVVFLIMFRTEKDLDPDRDPANPDATPLRSTDTHLPLLFSPDPEAPHPPGQPGP
>NZ_CP045325.1|WP_152514988.1|208381_209632_-|peptidoglycan-DD-metalloendopeptidase-family-protein
MQIRPLIAAASLTTLMLCAACATDPETKNAGTTAQATPPPPAAADSTPPPLPGPAVLTPVVGRVLAAPIPVPATDGKIHLAYELVLTNTTPQDVTLTGVDVRAGDRTLLSLPGERLTYWTRLAGNPVPTTTLGPAQTGYVWLDVAVDPDETVPAELSHTVAISVTDPSPPLIPASLTENIAPVTVQTRQPISIAPPLKGPNWLDGDSCCDMSAHRTALNPIDGEIWAAERFAIDYVQLGPDGRLFTGDETQLDSYPYVGSDVVAVGEGPVVSVVDGLPEQVPGTAPTDLPLEEYGGNHVVQDLGGGNYAFYAHLQTGSVQVEPGDHLSTGQVLGALGNSGNSDAPHLHFHVMSTPDPLRSNGLPFVFTDFRLDSRSTGDLDALLEGKPAELEPGFAPRDESGTSPLVYDVMTYAES
>NZ_CP045325.1|WP_152514987.1|208026_208395_-|DUF3054-family-protein
MPKADRSTAVKALAADAVCVVVFCTIGRRSHAEGLTVAGIAETAWPFLAGTAVGWLLAQAWRRPIAVIPTGLAVWLATVVVGMLLRKATGQGTAASFIVVASLTTAVLLLGWRAGARAVSRR
>NZ_CP045325.1|WP_152514986.1|206586_207942_+|HAMP-domain-containing-protein
MTRPKLPRFLRSASLRTRVAIASAAAAAAVVAAFTILTSVVLANNDATQLDRRLDAIVDASMFPEELSDPRRGVLTTGRDRTSGQVVFQRGFQLPPLPPGTETAFVNGVEYRVRTVPVEQDGGLLMSIGIRADSVLLNRARIPLYIAVGVVTVLIAAGLGWLLAGPAIRPLRKLTENTKRLGKDAEDIPAVHGVREAEDLSEAMSAMLSRLAAAQRATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHNLPDDERDEVVADLSRAQRRVEGIITALGQLASGQLAQVEDREVIDLTDMLDRVARENMRGANQVQIDVVLDDDLGTLLGWPSGLRLAVDNLVRNAVTHGQASRIVLSSHRHGGVVTIVVDDNGRGLPADEHETVLGRFSRGSNAAPGGSGLGLALVAQQAALHGGTIELSDSPLGGLRATLTVSTAPNESWTPPNEI
>NZ_CP045325.1|WP_173012153.1|205902_206571_+|response-regulator-transcription-factor
MVDDDPDVRTSVARGLRHSGFDVRVAATGREALRLLSSEPHDALVLDVQMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLHALLRRAHHSDPGSDTLTVGSLTIDTARRLVFVAGERVELTKREFDLLAALAENAGVVLSRQRLLELVWGYDFDVDTNVADVFVSYLRRKLERDGLPRVIHTVRGIGYVLREDP
>NZ_CP045325.1|WP_152514984.1|205431_205818_+|hemophore-related-protein
MLFSAPTVRRAVAGALGAGALGATLFGVLPAASAQPAPPNCTAADFAGVASGVSAASSAYLFTHPDVNDFFTSLHGLPREEIKTRVMDYMNAHPQERDELTAIRQPLVDIKNRCGYAFADAGDPDMPE
>NZ_CP045325.1|WP_152514983.1|204696_205242_+|hemophore
MDAPKTFIAPFVRTALGAVAAGGAVTLALVTGPAAGAAPDPCAASSVAKTVGAVATNTGVYLAAHPETDQALTAISQQPPGPQSVAMLKAYFDSNPEVATDMQRLQQPLATLSGRCRLPVTLPQMLGLLQSVQQGQGQSVQQGQGQGLPAQLPATQNVGAETTPAPGARGAVSSEARGAVS
>NZ_CP045325.1|WP_152514982.1|201502_204430_-|MMPL-family-transporter
MMRVSSNLRRFRWAVFAVWILLLVPSVHLALNQSGNLTGGGFEVEGSQSLYVQRQLEAQFPDQGASPLALVADPRPDASFDDMNEAVAFLERVAAEVPSVTVMPNPQQPPPQPDRPYVLTLQISFDNTGAVDIANQLREKVGIDGEDAGEMDNGKVRLYVIGQGALGAAATLATKNDIAQAEKWNFPIVLLILLAVFGSLAAAAMPLLLGICTVAVTMGLVFLLSMHMTMSVFVTSTVSMFGIAVAIDYSLFILMRFREELRAGREPQDAADAAMATSGLAVVLSGLTVIASVTGLYLINTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRRVEATQSRFWTRWTGWVMRRPWASALAAAALLLTLAAPAFSMTLGNSMQRQFDPTHEIRGGVNAAAVALGPGALGPVRVLVTFPDGNAASAPAKEPLLNAVRQKMTEAPNVVSVTPAVFGNDYRSALLSAVLSVDPEEMGARDTVDWMRDQLPAVAEGQALVNVGGPTALIKDFDDRVAKTQPLVFGFVALIAFVMLLISIRSVFLALKGVLMTVLSVAAAYGSLVVVFQWGWLSDLGFKQLSSLDSTIPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTITSAALIMIAVFIGFAFSGMPLVAQLGVASAVAIAVDATVVRLVLVPALMAMFDEWNWWLPRWLDRILPSVDFEKPLPKADIGDLVIIPDDISALAPSGADLRTVVKSAAKLKTLAPQAITVADPLAFSGCQPCAKSMGGRLVEKRTPVAVGNRAHGKTVAVKLPKHPVTMWRGRLDVALDALGVQAGGPDGGSPLQRTDPMETTNVLLPTGDRLQIPTGAETLRLKSFLIMARNNARDYTELADLVDAMDTQTAAEVLTGMDRYYSGPPAGAQRANTLNGHWVATQLVRRLADPQPSDGPDFTREGAEAEWARVRQRCLTVAVAMLEEAR
>NZ_CP045325.1|WP_152514981.1|201014_201506_-|XRE-family-transcriptional-regulator
MTVTGEVRGSNRDAASPPPVDTRPVEFWPTAAIRAALENDDLSVWQRIVVAIKRDPYGRTARQVEEVLETARPYGVSRAMSEVLVRTREHLEANECAEVAKHVHLLLERSGLGEQEFASRIGVPAEDFATYLQGSVSPPASLMIRMGRLSDRFARMRAQRADQ
>NZ_CP045325.1|WP_152514992.1|217606_223588_-|tandem-95-repeat-protein
MSKQRLGQAFVSAGSTTRRSSRSAAECIGRVGALAASLGVGAVLFAAPWTAAADAEGSSGSGDTSSTSEAGSTESTESSSTAQATDDSTGDSSAGETESDDAEPESSSDDGDLEAELTEELGEELDDIEDDTDSEEEDGSSSGDGDAPVDLDDVTAADTVAEVVTVEEDVDSGGGSGPVESESEPVVDVDAAVPAAPEVLPESAPVEAMMIEVEETAPSRSSYTSASVMSARTSTAEITEAPAKALQAQPGTFLEVASSMLSAVIAPFVTTPAAPAAPSAQPLMWGVLSWVRRELDDTFANFSISIGGRQIVQNGTAYATSQGFGSFAIAHGENAVASASGLFNVAIVRGDDSTATSEGNFTRVRVRGDDNTAGADGPGSRASIYGDQNTAETTGAYTSIYVRGVGNAVTGTGDGTRATVTGDDNDATVLATNGSRAQITVRGDENSATASAEDDSTALVRIIGDGSTAVADAEADGYAAARITGDSNVASSDAMGETSIVRITGDDNAAWATASQARAEATVFGDSNFAEATDGNAVISGDGSIADADGPGSVARVWGDGSKASALGEDNTAFVWGDDSRAIAGPGTGNTAISLGNNLIADTGPGDGNTVYGQPFDPENQAPVAGAPGAQTVDPQTGTVTGTLGFTDPDSDTLTYSVTTDPANGSVTVNANGTYTYTPATRPDFGDPDGADSFTVTASDGQATATATIDVPVTAQPEPGNQAPVAGTPGEQTVDPETGTVTGTLGFTDPDGDELTYTATAPGNGSVTVNTDGTYTYTPATRPAAGEPNGTDAFTVTATDPAGLSASTTIDVPVTALPQPGNTAPVANPDTYSVDEDTVLVVTGPGVLGNDTDAESDGLTAVLSAGPVNGSFVLNPDGSFTYTPDSGYTGADSFTYTATDGALVSETATVTITVNPAVVDPPNTVIGTVDVGENPNAVSVTPDGTRVYVVNGGNLFNEDNASVTVIDVSDPANPTVLQTIPFDIYNPREIEISPDGLRAYVAYDNVVGGNGHLLVIDTDPASATYNTVIGDPIEVGDGPTDIEFTPDGTRAIILNQSSLDVVILDTDPTSASFHTLIGTPIRVANSSPRALALTPQGSRAYITIPRSGADTVVVLDINPDSDGYGTLIGDPIAVGDSPDDIEIAPNGARAYVVNAGDDTVSVIDTNPLSATYNTVIGNPIPVGDLPQSLVFTPDGTRAYVANGFDGEVVVIDTDPSSITFNFVIGEPIGVGARPDALAVSADGTHLYVVNDNDETVSVIYLGPSADPYNNAPSAGEDTFITNENAAVTGNVLANDFDVDGDSLTAELVTGPANGTLSLSPDGTFTYTPSHGFAGTDSFTYAVSDGALTDTATAAITVNAVGGDPVALGTVELPGELVGPLVIGADGLAYQTTETDGVVYVTVVDPSDPTSAITVELPGSATGAVQFGTDGTAYQISTAADVTHVAVIDPSAPAAATILEVPGSFEYTVFDGDTTYLVTGTGSTATHVTVIDPTAPTGAVTVDLTGEPADPLVIGPDGLAYQTTRSTSGGDDITHVTVIDPANPAAAITIELPGFTSEPVVFGPGGGYQTSYSGSFSSGYLTHVTKFDLGTLANPTTIDLTEDPDGSVMFGPEGTGYQLHGDFSRSYVTLIDPQDFTNPVTITLTGYRTEEVTFSDTGDAYVTSRTGTTTTHVTVIDPTDPTNATVIALPGTHDEPVAFFPDGTAYQFSETRTPGTDEYVTHLTVIDPADLTNYTTVDLAGQQILTRVIGADGTVYQRLRTIDTSGDEFFHVAVIDPANPTTPTVIDLPGYPVGELLTGGDGTLYQTSYSGVTSLYTVHVTIIDPEDPANPATVERTQYDPFFNYSLTNGYDPGLRVGEDGTAFLTNTATDLDGIDYPSATRVTVIDPAEPENAITIDVAGNPDGAVVIAPDGTAYQTVGTNNREFIPTWFTHVVVIDPEDPANPVVVDLLGQAVGPVTIGADGVVYQLTETVEDGVRNRQLTTIGVAGSAIDV
>NZ_CP045325.1|WP_152514993.1|223781_226754_-|MMPL-family-transporter
MFAWWGRTVYQYRYIVIGVMVALCLGGGVYGISLGQHVTQSGFYDEGSESVHASLVSDEAYGRDRTSHVVAILTPPDGEKVTDPQWMEKVTGELNDLVEEHPDQIVSWVGWLRAPDTDSAQVQQMKTADDSKTFISIPLKGDDDDTILKNYQAIEPDLKKVNDGDIQLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGGVVAASLPAIIGGLTIAGALGVMRFAAEFMPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTIMTSGRTVMFSAVIIVASSLPLLLFPQGFLKSITYAIIASVMLASILSITVLAATLGILGRNVDALGVRTLLRVPFFRNWKPMNWWLNWLADRLQKTKTREEVEKGFWGRLVNVVMKRPIAFAAPILIVMILLVIPLGQLSLGGISEKYLPPDNSVRLAQENFDQSFPGFRTEPLTLVVERDDGEPVTDQQMAEIRSKAMNISGFTDPDNDPTKMWQERSVQEGGSEDPSVRVIQNGLVNRNDAAEKIDELRAISPPRGITLSVGGTPALEQDSIHSLFDKLPLMVTVLIVTTTILMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVEGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAIMKLLGDDCWWAPRWMKRLQDRLGLGETELPDERKRPSVRESGEPSQPAEPAHPEALVGAGGPPVAVSGRVQPHDPTHPGPGVPGRGTPPRPSGPSAAGTSRLPSAPPRPAPAEEPQTTRLSIAKDAVRNAVTNATAVTQRTPRATPPPAPKREDREIESWLGDLRGTGAAPVAPQPKPPSAEPTRAMPEPGGNEPTTAIPAQREPRPQQDDSAEETRAIPTARRGDAEAATEKLNTRGDDERQRRGGSSGVSAQELLRREGRL
>NZ_CP045325.1|WP_152514994.1|226824_227541_-|NYN-domain-containing-protein
MSVTENIPDMSADGTAPGDDAGAPGTPTASRVLLVWDAPNLDMGLGSILGGRPTAAHRPRFDALGRWLLARTADLSAQHAQAGRSVALEPEATVFTNIAPGSADVVRPWVEALRNVGFAVFAKPKIDDDSDVDSDMLEHIALRRTEGLAAVLVASADGQAFKQPLENLAEEGVEVQVLGFREHASWALASDTLEFVDLEDIDGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLASRV
>NZ_CP045325.1|WP_152514995.1|227537_228323_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSDHGRMHAPGPDVADELASSGSVAPGQDAPAHGHRRVTSFRARRSTISDRQQAIWDERWPQLGTEARHGESPAPLLDTDAWFGRQAPLILEIGCGTGTSTLAMAQAEPDLDVIAVEVYRRGLAQLLSAIDRAEVTNIRLVRGDGVDVLTHMVGPDSLTGVRVFFPDPWPKARHHKRRLLQADTMALIADRLRPGGVLHAATDHLGYAEHIAEVGDAEPRLRRIDRDTAELPISVSRPVTKYERKALAGPIVTELLWERIP
>NZ_CP045325.1|WP_152519440.1|228562_229483_+|hypothetical-protein
MGTVESRVRAAVRVAVTGRQGVGRSQVATALSGAGLVVTPDVDGADAHVRVIAEALKPEDERALRDRSVPAVVVLNKADLAGADPGGPLAGAERAAARLAAERGLPVVPMVASLADVALGDEDMAALRALARCAADMTSTDAFVAAPHDVPGAVRSRLLVMLDRFGLAHAILAVAEGAAAGPVAQRLRELSHLDRVLDRLTAAAAPVRYHRIAAALVELRILAACSGDEQLAAFCCADDTVLAVSAAAVDVVEASGGSVAGGDGPEDHLKRALRWRSYGQGPVSPLHQRCADDIVRGSLRLLDRVR
>NZ_CP045325.1|WP_152514996.1|229488_230853_+|hypothetical-protein
MTARTTVVHVTGPPRAGVSSVAACLRDRMPDVTVVDAADPARTRDVPDVPDVVVFVVSAVAPVTESDCVLAVSACRSTDAVIAVLTKIDDHRDWRGVLATSRQRLADCAARFASVRWVTAAAAPRLGEPAVDDVVAALTAALSDPDLARRNTLRRWEARLGAALTGMHAADSGHLARVSALRAHRDTLVRNHLPSGAVSVRHPMQRARLELASAARQRCVTLRTELLEAAAETTAVAEIEERVRRRCGEVIAEVDEQTERRLHDLASELGAGLPEPSAVAEVCLGDPPLRQRRLEARVTTVLGAGFGFGAGLVVARWVTGLAPGLTVAGALVGAAVGLALTLWVVAARALLYRRAVLAQWIGEATGTVRTALDERIASRLLAAEAAVTTARLAQRAGMAERVAECDAQLRGHVLAARRAQALREASEPGLARVLTVVRDGLREPDSTRTLVTDR
>NZ_CP045325.1|WP_152514997.1|231048_232878_+|phosphoenolpyruvate-carboxykinase-(GTP)
MTAATIPGLDSAPTKHEGLLAWVREVAELTQPDRVAWADGSDEENQALCDQLVEAGTFQKLNPEKKPNSYLALSDPSDVARVESRTFICSQREIDAGPTNNWMDPAEMRGLMTDLYRGSMRGRTMWVVPFCMGPLEAEDPKLGVEITDSEYVVVSMRTMTRMGRAALDKMGTDGFFVKALHSIGAPLEPGEKDVPWPCNDTKYITHFPETREIWSFGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYIAAAFPSACGKTNLAMLQPTIPGWRAETVGDDIAWMRFGKDGRLYATNPEFGFFGVAPGTNWDSNPNAMKTIAAGNTVFTNVAKTDDGDVWWEGLEGEPDHLIDWKGNDYILRETETKAAHPNSRYCTPISQCPTLAPEWDDPQGVPISAILFGGRRKTTVPLITEARDWQHGVFIGATLGSEQTAAAEGKVGTVRRDPMAMLPFMGYNVGDYFQHWINIGKQADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWAIERIEHTADGKSTPIGIVPTAADLDLDGLDVDAADVDEALKVVPDEWRNELPLIEEWFEFVGEKLPTSIKDEFDALKHRLDEAE
>NZ_CP045325.1|WP_152514998.1|233044_233275_+|antitoxin
MKLSVSLSDDDVAVLDAYVKNAGLASRSAALQHAVRMLRHAALEHDYEAAWSEWSESEEAGLWAEPLDDGLGDAPR
>NZ_CP045325.1|WP_152519441.1|233261_233609_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MRRGEIWQVDLDPARGNEANKRRPAVIVSNDRANATAGRLGRGVITLVPITSNVANVYPFQVRLTAATSGLTALSKAQAEQVRSVSVERLLRRIGRVSPTELDQLDEALRLHLQL
>NZ_CP045325.1|WP_152514999.1|233710_235234_+|AMP-binding-protein
MQIRDTAVATPDKPAVIMYPSGTVVTFGELEARANRLAHLFRKAGLVEGDAVAILMENNAHMHAVMWAARRAGLYYVPINTHLTAAEAAYIIDNSAAKAIVGSAKLTDTLAGLADELPNGLPSLLLIADGTLQGWSSYPECVADQPDTPIDDEIEGDLLQYSSGTTGRPKGIKRELPHVPPSEAPGLMAALVSFWMHPDTVYLSPAPLYHTAPSVWSMQTQAGGITTVVMEKFDAEGALDAIAKHRVTHGQFVPVMFTRMLKLPDEVRKAYDVSSLERVMHAAAPCPVEIKKQMIDWWGPIVDEYYASSEAHGSTLITAEEWLTHPGSVGRPLAGAVHIVGEDGTELPPGEPGEIYFEGGFDFEYLNDPDKTASSRHASGWKTVGDIGYVDEEGYLYLTDRRHHMIISGGVNIYPQEAENLLVTHPKVMDAAVFGVPDDEMGQRVKAVVQTVDPADATPEFADELLAWLRDRLAHYKCPRSISFEAQLPRTDTGKLYKQELIARYSR

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Crispr_ID: NZ_CP045325_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045325_1

215746-215878

Orphan

Consensus_repeat	Method
GCCACGGCGGTGCTCTCGTCGCCG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP045325_1

>merge|NZ_CP045325|1|215746-215878|CRISPRCasFinder
GCGGTCGCGGTGCTGCCGTCACCGGAGATCACGGCCTTGCCGTCGGTGGCCTGGGCGGCATTGCCGTCGCCGAAGGTGGTGGCCTCGGCGCGGGCGTCGGTGGCAGTCGCCGACGCGGTGCTGTCAGCGCCGG

>NZ_CP045325|1|1|215746-215878|CRISPRCasFinder
GCGGTCGCGGTGCTGCCGTCACCG	GAGATCACGGCCTTGCCGTCGGTG
GCCTGGGCGGCATTGCCGTCGCCG	AAGGTGGTGGCCTCGGCGCGGGCGTCGGTGGCAGTC
GCCGACGCGGTGCTGTCAGCGCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045325.1\|WP_152514988.1\|208381_209632_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_CP045325.1\|WP_152514997.1\|231048_232878_+\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NZ_CP045325.1\|WP_152514993.1\|223781_226754_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP045325.1\|WP_152514994.1\|226824_227541_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NZ_CP045325.1\|WP_152514984.1\|205431_205818_+\|hemophore-related-protein	unknown	unknown	gnl\|CDD\|374603
NZ_CP045325.1\|WP_152514995.1\|227537_228323_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP045325.1\|WP_152514989.1\|209650_210817_-\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|223469
NZ_CP045325.1\|WP_173012153.1\|205902_206571_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP045325.1\|WP_152519440.1\|228562_229483_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|206686
NZ_CP045325.1\|WP_152514998.1\|233044_233275_+\|antitoxin	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514986.1\|206586_207942_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP045325.1\|WP_152514990.1\|210894_212046_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|279875
NZ_CP045325.1\|WP_152519441.1\|233261_233609_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP045325.1\|WP_152514981.1\|201014_201506_-\|XRE-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514999.1\|233710_235234_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236215
NZ_CP045325.1\|WP_152514982.1\|201502_204430_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP045325.1\|WP_152514996.1\|229488_230853_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514987.1\|208026_208395_-\|DUF3054-family-protein	unknown	unknown	gnl\|CDD\|378616
NZ_CP045325.1\|WP_152514992.1\|217606_223588_-\|tandem-95-repeat-protein	unknown	unknown	gnl\|CDD\|225926
NZ_CP045325.1\|WP_152514983.1\|204696_205242_+\|hemophore	unknown	unknown	gnl\|CDD\|275323

Protein	Function_ID	Function_description	E-value
NZ_CP045325.1\|WP_152514988.1\|208381_209632_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.74365e-14
NZ_CP045325.1\|WP_152514993.1\|223781_226754_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.77834e-138
NZ_CP045325.1\|WP_152514994.1\|226824_227541_-\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.22829e-06
NZ_CP045325.1\|WP_152514984.1\|205431_205818_+\|hemophore-related-protein	gnl\|CDD\|374603	pfam16525, MHB, Haemophore, haem-binding. MHB is a coiled-coil molecule that binds free haem in mycobacterial cytoplasm to deliver it to membrane proteins for shuttling through the membrane.	3.5727e-37
NZ_CP045325.1\|WP_152514995.1\|227537_228323_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	1.26748e-86
NZ_CP045325.1\|WP_152514989.1\|209650_210817_-\|flippase-like-domain-containing-protein	gnl\|CDD\|223469	COG0392, COG0392, Predicted integral membrane protein [Function unknown].	2.61037e-43
NZ_CP045325.1\|WP_173012153.1\|205902_206571_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.48516e-81
NZ_CP045325.1\|WP_152519440.1\|228562_229483_+\|hypothetical-protein	gnl\|CDD\|206686	cd01899, Ygr210, Ygr210 GTPase. Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.	0.0017184
NZ_CP045325.1\|WP_152519441.1\|233261_233609_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	8.03134e-32
NZ_CP045325.1\|WP_152514986.1\|206586_207942_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.00981e-43
NZ_CP045325.1\|WP_152514990.1\|210894_212046_+\|AI-2E-family-transporter	gnl\|CDD\|279875	pfam01594, AI-2E_transport, AI-2E family transporter. This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.	1.84455e-57
NZ_CP045325.1\|WP_152514999.1\|233710_235234_+\|AMP-binding-protein	gnl\|CDD\|236215	PRK08276, PRK08276, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP045325.1\|WP_152514982.1\|201502_204430_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	4.65724e-136
NZ_CP045325.1\|WP_152514997.1\|231048_232878_+\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP045325.1\|WP_152514987.1\|208026_208395_-\|DUF3054-family-protein	gnl\|CDD\|378616	pfam11255, DUF3054, Protein of unknown function (DUF3054). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	9.33774e-25
NZ_CP045325.1\|WP_152514992.1\|217606_223588_-\|tandem-95-repeat-protein	gnl\|CDD\|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	7.26178e-22
NZ_CP045325.1\|WP_152514983.1\|204696_205242_+\|hemophore	gnl\|CDD\|275323	TIGR04530, hemophoreRv0203, hemophore, mycobacterial-type. Members of this family, including Rv0203 from Mycobacterium tuberculosis, are secreted heme-binding proteins used in heme acquisition. Such proteins are called hemophores. Members have a cleavable N-terminal signal peptide, and a mature region just over 100 amino acids long with a pair of invariant Cys residues. An unrelated hemophore, HasA, occurs in Gram-negative pathogens such as Yersinia pestis. [Transport and binding proteins, Other].	1.59488e-40

>NZ_CP045325.1|WP_152514990.1|210894_212046_+|AI-2E-family-transporter
MSAGPSLDPLADESVTPLVRKTAAWAWRLLIILAAVVALGWLILRLEILFVPVALATIVAALLMPVVDFLDRRGAPRSGAVALVLLSGFAVFGGLLAFVITQFIEGVPALAGQVSTSIEGVGAWLTDGPLKVSEQQINQFRDSALEALRDNQERLTSGAVSTAATVTEIVTGALLMLFTLIFLLYGGRNIFTFVTGVVPTGVRARVRNAGRAGFHTLIGYVRATFLVAAVDATGIGLGLAIMGVPLALPLASLVFMGAFVPLVGAVVTGFLAVIVALIAKGWIYALITLGLIIAVQQLEGHVLQPLVMGRAVSIHPLAIVLAIAGGAVLAGIVGALLAVPVLAFLNSAVRVLLADDPVAEEEAQEADDAPVIEAEPDDVEQLE
>NZ_CP045325.1|WP_152514989.1|209650_210817_-|flippase-like-domain-containing-protein
MSHDAPASGSPAGAANPERSRGKYWWLRWALIALALVVLTVELALVHDQLAKAWKSLYSANWMWVLAAVVAAMASMHSFAQIQRTLLRSAGVHVHQWRSEAAFYAGNALSTTMPGGPVLSATFIYRQQRMWGASPVVASWQLVMSGALQVIGLALLGLGGAFMLGASKNPLSLIFSLGGFVALILLAQAVASRPELIDGIGVRLLSWFNSVRGKPADTGLTKWRATLVQLESVQLGRRDLGEAFSWSLFNWVADVGCLLFACYATGGHPSVAGVTVAYAAARAVGSIPLMPGGLLVVEAVLVPGLVSSGMSLASAISAMLIYRLVSWIFIAAIGWVVFLIMFRTEKDLDPDRDPANPDATPLRSTDTHLPLLFSPDPEAPHPPGQPGP
>NZ_CP045325.1|WP_152514988.1|208381_209632_-|peptidoglycan-DD-metalloendopeptidase-family-protein
MQIRPLIAAASLTTLMLCAACATDPETKNAGTTAQATPPPPAAADSTPPPLPGPAVLTPVVGRVLAAPIPVPATDGKIHLAYELVLTNTTPQDVTLTGVDVRAGDRTLLSLPGERLTYWTRLAGNPVPTTTLGPAQTGYVWLDVAVDPDETVPAELSHTVAISVTDPSPPLIPASLTENIAPVTVQTRQPISIAPPLKGPNWLDGDSCCDMSAHRTALNPIDGEIWAAERFAIDYVQLGPDGRLFTGDETQLDSYPYVGSDVVAVGEGPVVSVVDGLPEQVPGTAPTDLPLEEYGGNHVVQDLGGGNYAFYAHLQTGSVQVEPGDHLSTGQVLGALGNSGNSDAPHLHFHVMSTPDPLRSNGLPFVFTDFRLDSRSTGDLDALLEGKPAELEPGFAPRDESGTSPLVYDVMTYAES
>NZ_CP045325.1|WP_152514987.1|208026_208395_-|DUF3054-family-protein
MPKADRSTAVKALAADAVCVVVFCTIGRRSHAEGLTVAGIAETAWPFLAGTAVGWLLAQAWRRPIAVIPTGLAVWLATVVVGMLLRKATGQGTAASFIVVASLTTAVLLLGWRAGARAVSRR
>NZ_CP045325.1|WP_152514986.1|206586_207942_+|HAMP-domain-containing-protein
MTRPKLPRFLRSASLRTRVAIASAAAAAAVVAAFTILTSVVLANNDATQLDRRLDAIVDASMFPEELSDPRRGVLTTGRDRTSGQVVFQRGFQLPPLPPGTETAFVNGVEYRVRTVPVEQDGGLLMSIGIRADSVLLNRARIPLYIAVGVVTVLIAAGLGWLLAGPAIRPLRKLTENTKRLGKDAEDIPAVHGVREAEDLSEAMSAMLSRLAAAQRATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHNLPDDERDEVVADLSRAQRRVEGIITALGQLASGQLAQVEDREVIDLTDMLDRVARENMRGANQVQIDVVLDDDLGTLLGWPSGLRLAVDNLVRNAVTHGQASRIVLSSHRHGGVVTIVVDDNGRGLPADEHETVLGRFSRGSNAAPGGSGLGLALVAQQAALHGGTIELSDSPLGGLRATLTVSTAPNESWTPPNEI
>NZ_CP045325.1|WP_173012153.1|205902_206571_+|response-regulator-transcription-factor
MVDDDPDVRTSVARGLRHSGFDVRVAATGREALRLLSSEPHDALVLDVQMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLHALLRRAHHSDPGSDTLTVGSLTIDTARRLVFVAGERVELTKREFDLLAALAENAGVVLSRQRLLELVWGYDFDVDTNVADVFVSYLRRKLERDGLPRVIHTVRGIGYVLREDP
>NZ_CP045325.1|WP_152514984.1|205431_205818_+|hemophore-related-protein
MLFSAPTVRRAVAGALGAGALGATLFGVLPAASAQPAPPNCTAADFAGVASGVSAASSAYLFTHPDVNDFFTSLHGLPREEIKTRVMDYMNAHPQERDELTAIRQPLVDIKNRCGYAFADAGDPDMPE
>NZ_CP045325.1|WP_152514983.1|204696_205242_+|hemophore
MDAPKTFIAPFVRTALGAVAAGGAVTLALVTGPAAGAAPDPCAASSVAKTVGAVATNTGVYLAAHPETDQALTAISQQPPGPQSVAMLKAYFDSNPEVATDMQRLQQPLATLSGRCRLPVTLPQMLGLLQSVQQGQGQSVQQGQGQGLPAQLPATQNVGAETTPAPGARGAVSSEARGAVS
>NZ_CP045325.1|WP_152514982.1|201502_204430_-|MMPL-family-transporter
MMRVSSNLRRFRWAVFAVWILLLVPSVHLALNQSGNLTGGGFEVEGSQSLYVQRQLEAQFPDQGASPLALVADPRPDASFDDMNEAVAFLERVAAEVPSVTVMPNPQQPPPQPDRPYVLTLQISFDNTGAVDIANQLREKVGIDGEDAGEMDNGKVRLYVIGQGALGAAATLATKNDIAQAEKWNFPIVLLILLAVFGSLAAAAMPLLLGICTVAVTMGLVFLLSMHMTMSVFVTSTVSMFGIAVAIDYSLFILMRFREELRAGREPQDAADAAMATSGLAVVLSGLTVIASVTGLYLINTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRRVEATQSRFWTRWTGWVMRRPWASALAAAALLLTLAAPAFSMTLGNSMQRQFDPTHEIRGGVNAAAVALGPGALGPVRVLVTFPDGNAASAPAKEPLLNAVRQKMTEAPNVVSVTPAVFGNDYRSALLSAVLSVDPEEMGARDTVDWMRDQLPAVAEGQALVNVGGPTALIKDFDDRVAKTQPLVFGFVALIAFVMLLISIRSVFLALKGVLMTVLSVAAAYGSLVVVFQWGWLSDLGFKQLSSLDSTIPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTITSAALIMIAVFIGFAFSGMPLVAQLGVASAVAIAVDATVVRLVLVPALMAMFDEWNWWLPRWLDRILPSVDFEKPLPKADIGDLVIIPDDISALAPSGADLRTVVKSAAKLKTLAPQAITVADPLAFSGCQPCAKSMGGRLVEKRTPVAVGNRAHGKTVAVKLPKHPVTMWRGRLDVALDALGVQAGGPDGGSPLQRTDPMETTNVLLPTGDRLQIPTGAETLRLKSFLIMARNNARDYTELADLVDAMDTQTAAEVLTGMDRYYSGPPAGAQRANTLNGHWVATQLVRRLADPQPSDGPDFTREGAEAEWARVRQRCLTVAVAMLEEAR
>NZ_CP045325.1|WP_152514981.1|201014_201506_-|XRE-family-transcriptional-regulator
MTVTGEVRGSNRDAASPPPVDTRPVEFWPTAAIRAALENDDLSVWQRIVVAIKRDPYGRTARQVEEVLETARPYGVSRAMSEVLVRTREHLEANECAEVAKHVHLLLERSGLGEQEFASRIGVPAEDFATYLQGSVSPPASLMIRMGRLSDRFARMRAQRADQ
>NZ_CP045325.1|WP_152514992.1|217606_223588_-|tandem-95-repeat-protein
MSKQRLGQAFVSAGSTTRRSSRSAAECIGRVGALAASLGVGAVLFAAPWTAAADAEGSSGSGDTSSTSEAGSTESTESSSTAQATDDSTGDSSAGETESDDAEPESSSDDGDLEAELTEELGEELDDIEDDTDSEEEDGSSSGDGDAPVDLDDVTAADTVAEVVTVEEDVDSGGGSGPVESESEPVVDVDAAVPAAPEVLPESAPVEAMMIEVEETAPSRSSYTSASVMSARTSTAEITEAPAKALQAQPGTFLEVASSMLSAVIAPFVTTPAAPAAPSAQPLMWGVLSWVRRELDDTFANFSISIGGRQIVQNGTAYATSQGFGSFAIAHGENAVASASGLFNVAIVRGDDSTATSEGNFTRVRVRGDDNTAGADGPGSRASIYGDQNTAETTGAYTSIYVRGVGNAVTGTGDGTRATVTGDDNDATVLATNGSRAQITVRGDENSATASAEDDSTALVRIIGDGSTAVADAEADGYAAARITGDSNVASSDAMGETSIVRITGDDNAAWATASQARAEATVFGDSNFAEATDGNAVISGDGSIADADGPGSVARVWGDGSKASALGEDNTAFVWGDDSRAIAGPGTGNTAISLGNNLIADTGPGDGNTVYGQPFDPENQAPVAGAPGAQTVDPQTGTVTGTLGFTDPDSDTLTYSVTTDPANGSVTVNANGTYTYTPATRPDFGDPDGADSFTVTASDGQATATATIDVPVTAQPEPGNQAPVAGTPGEQTVDPETGTVTGTLGFTDPDGDELTYTATAPGNGSVTVNTDGTYTYTPATRPAAGEPNGTDAFTVTATDPAGLSASTTIDVPVTALPQPGNTAPVANPDTYSVDEDTVLVVTGPGVLGNDTDAESDGLTAVLSAGPVNGSFVLNPDGSFTYTPDSGYTGADSFTYTATDGALVSETATVTITVNPAVVDPPNTVIGTVDVGENPNAVSVTPDGTRVYVVNGGNLFNEDNASVTVIDVSDPANPTVLQTIPFDIYNPREIEISPDGLRAYVAYDNVVGGNGHLLVIDTDPASATYNTVIGDPIEVGDGPTDIEFTPDGTRAIILNQSSLDVVILDTDPTSASFHTLIGTPIRVANSSPRALALTPQGSRAYITIPRSGADTVVVLDINPDSDGYGTLIGDPIAVGDSPDDIEIAPNGARAYVVNAGDDTVSVIDTNPLSATYNTVIGNPIPVGDLPQSLVFTPDGTRAYVANGFDGEVVVIDTDPSSITFNFVIGEPIGVGARPDALAVSADGTHLYVVNDNDETVSVIYLGPSADPYNNAPSAGEDTFITNENAAVTGNVLANDFDVDGDSLTAELVTGPANGTLSLSPDGTFTYTPSHGFAGTDSFTYAVSDGALTDTATAAITVNAVGGDPVALGTVELPGELVGPLVIGADGLAYQTTETDGVVYVTVVDPSDPTSAITVELPGSATGAVQFGTDGTAYQISTAADVTHVAVIDPSAPAAATILEVPGSFEYTVFDGDTTYLVTGTGSTATHVTVIDPTAPTGAVTVDLTGEPADPLVIGPDGLAYQTTRSTSGGDDITHVTVIDPANPAAAITIELPGFTSEPVVFGPGGGYQTSYSGSFSSGYLTHVTKFDLGTLANPTTIDLTEDPDGSVMFGPEGTGYQLHGDFSRSYVTLIDPQDFTNPVTITLTGYRTEEVTFSDTGDAYVTSRTGTTTTHVTVIDPTDPTNATVIALPGTHDEPVAFFPDGTAYQFSETRTPGTDEYVTHLTVIDPADLTNYTTVDLAGQQILTRVIGADGTVYQRLRTIDTSGDEFFHVAVIDPANPTTPTVIDLPGYPVGELLTGGDGTLYQTSYSGVTSLYTVHVTIIDPEDPANPATVERTQYDPFFNYSLTNGYDPGLRVGEDGTAFLTNTATDLDGIDYPSATRVTVIDPAEPENAITIDVAGNPDGAVVIAPDGTAYQTVGTNNREFIPTWFTHVVVIDPEDPANPVVVDLLGQAVGPVTIGADGVVYQLTETVEDGVRNRQLTTIGVAGSAIDV
>NZ_CP045325.1|WP_152514993.1|223781_226754_-|MMPL-family-transporter
MFAWWGRTVYQYRYIVIGVMVALCLGGGVYGISLGQHVTQSGFYDEGSESVHASLVSDEAYGRDRTSHVVAILTPPDGEKVTDPQWMEKVTGELNDLVEEHPDQIVSWVGWLRAPDTDSAQVQQMKTADDSKTFISIPLKGDDDDTILKNYQAIEPDLKKVNDGDIQLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGGVVAASLPAIIGGLTIAGALGVMRFAAEFMPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTIMTSGRTVMFSAVIIVASSLPLLLFPQGFLKSITYAIIASVMLASILSITVLAATLGILGRNVDALGVRTLLRVPFFRNWKPMNWWLNWLADRLQKTKTREEVEKGFWGRLVNVVMKRPIAFAAPILIVMILLVIPLGQLSLGGISEKYLPPDNSVRLAQENFDQSFPGFRTEPLTLVVERDDGEPVTDQQMAEIRSKAMNISGFTDPDNDPTKMWQERSVQEGGSEDPSVRVIQNGLVNRNDAAEKIDELRAISPPRGITLSVGGTPALEQDSIHSLFDKLPLMVTVLIVTTTILMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVEGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAIMKLLGDDCWWAPRWMKRLQDRLGLGETELPDERKRPSVRESGEPSQPAEPAHPEALVGAGGPPVAVSGRVQPHDPTHPGPGVPGRGTPPRPSGPSAAGTSRLPSAPPRPAPAEEPQTTRLSIAKDAVRNAVTNATAVTQRTPRATPPPAPKREDREIESWLGDLRGTGAAPVAPQPKPPSAEPTRAMPEPGGNEPTTAIPAQREPRPQQDDSAEETRAIPTARRGDAEAATEKLNTRGDDERQRRGGSSGVSAQELLRREGRL
>NZ_CP045325.1|WP_152514994.1|226824_227541_-|NYN-domain-containing-protein
MSVTENIPDMSADGTAPGDDAGAPGTPTASRVLLVWDAPNLDMGLGSILGGRPTAAHRPRFDALGRWLLARTADLSAQHAQAGRSVALEPEATVFTNIAPGSADVVRPWVEALRNVGFAVFAKPKIDDDSDVDSDMLEHIALRRTEGLAAVLVASADGQAFKQPLENLAEEGVEVQVLGFREHASWALASDTLEFVDLEDIDGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLASRV
>NZ_CP045325.1|WP_152514995.1|227537_228323_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSDHGRMHAPGPDVADELASSGSVAPGQDAPAHGHRRVTSFRARRSTISDRQQAIWDERWPQLGTEARHGESPAPLLDTDAWFGRQAPLILEIGCGTGTSTLAMAQAEPDLDVIAVEVYRRGLAQLLSAIDRAEVTNIRLVRGDGVDVLTHMVGPDSLTGVRVFFPDPWPKARHHKRRLLQADTMALIADRLRPGGVLHAATDHLGYAEHIAEVGDAEPRLRRIDRDTAELPISVSRPVTKYERKALAGPIVTELLWERIP
>NZ_CP045325.1|WP_152519440.1|228562_229483_+|hypothetical-protein
MGTVESRVRAAVRVAVTGRQGVGRSQVATALSGAGLVVTPDVDGADAHVRVIAEALKPEDERALRDRSVPAVVVLNKADLAGADPGGPLAGAERAAARLAAERGLPVVPMVASLADVALGDEDMAALRALARCAADMTSTDAFVAAPHDVPGAVRSRLLVMLDRFGLAHAILAVAEGAAAGPVAQRLRELSHLDRVLDRLTAAAAPVRYHRIAAALVELRILAACSGDEQLAAFCCADDTVLAVSAAAVDVVEASGGSVAGGDGPEDHLKRALRWRSYGQGPVSPLHQRCADDIVRGSLRLLDRVR
>NZ_CP045325.1|WP_152514996.1|229488_230853_+|hypothetical-protein
MTARTTVVHVTGPPRAGVSSVAACLRDRMPDVTVVDAADPARTRDVPDVPDVVVFVVSAVAPVTESDCVLAVSACRSTDAVIAVLTKIDDHRDWRGVLATSRQRLADCAARFASVRWVTAAAAPRLGEPAVDDVVAALTAALSDPDLARRNTLRRWEARLGAALTGMHAADSGHLARVSALRAHRDTLVRNHLPSGAVSVRHPMQRARLELASAARQRCVTLRTELLEAAAETTAVAEIEERVRRRCGEVIAEVDEQTERRLHDLASELGAGLPEPSAVAEVCLGDPPLRQRRLEARVTTVLGAGFGFGAGLVVARWVTGLAPGLTVAGALVGAAVGLALTLWVVAARALLYRRAVLAQWIGEATGTVRTALDERIASRLLAAEAAVTTARLAQRAGMAERVAECDAQLRGHVLAARRAQALREASEPGLARVLTVVRDGLREPDSTRTLVTDR
>NZ_CP045325.1|WP_152514997.1|231048_232878_+|phosphoenolpyruvate-carboxykinase-(GTP)
MTAATIPGLDSAPTKHEGLLAWVREVAELTQPDRVAWADGSDEENQALCDQLVEAGTFQKLNPEKKPNSYLALSDPSDVARVESRTFICSQREIDAGPTNNWMDPAEMRGLMTDLYRGSMRGRTMWVVPFCMGPLEAEDPKLGVEITDSEYVVVSMRTMTRMGRAALDKMGTDGFFVKALHSIGAPLEPGEKDVPWPCNDTKYITHFPETREIWSFGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYIAAAFPSACGKTNLAMLQPTIPGWRAETVGDDIAWMRFGKDGRLYATNPEFGFFGVAPGTNWDSNPNAMKTIAAGNTVFTNVAKTDDGDVWWEGLEGEPDHLIDWKGNDYILRETETKAAHPNSRYCTPISQCPTLAPEWDDPQGVPISAILFGGRRKTTVPLITEARDWQHGVFIGATLGSEQTAAAEGKVGTVRRDPMAMLPFMGYNVGDYFQHWINIGKQADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWAIERIEHTADGKSTPIGIVPTAADLDLDGLDVDAADVDEALKVVPDEWRNELPLIEEWFEFVGEKLPTSIKDEFDALKHRLDEAE
>NZ_CP045325.1|WP_152514998.1|233044_233275_+|antitoxin
MKLSVSLSDDDVAVLDAYVKNAGLASRSAALQHAVRMLRHAALEHDYEAAWSEWSESEEAGLWAEPLDDGLGDAPR
>NZ_CP045325.1|WP_152519441.1|233261_233609_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MRRGEIWQVDLDPARGNEANKRRPAVIVSNDRANATAGRLGRGVITLVPITSNVANVYPFQVRLTAATSGLTALSKAQAEQVRSVSVERLLRRIGRVSPTELDQLDEALRLHLQL
>NZ_CP045325.1|WP_152514999.1|233710_235234_+|AMP-binding-protein
MQIRDTAVATPDKPAVIMYPSGTVVTFGELEARANRLAHLFRKAGLVEGDAVAILMENNAHMHAVMWAARRAGLYYVPINTHLTAAEAAYIIDNSAAKAIVGSAKLTDTLAGLADELPNGLPSLLLIADGTLQGWSSYPECVADQPDTPIDDEIEGDLLQYSSGTTGRPKGIKRELPHVPPSEAPGLMAALVSFWMHPDTVYLSPAPLYHTAPSVWSMQTQAGGITTVVMEKFDAEGALDAIAKHRVTHGQFVPVMFTRMLKLPDEVRKAYDVSSLERVMHAAAPCPVEIKKQMIDWWGPIVDEYYASSEAHGSTLITAEEWLTHPGSVGRPLAGAVHIVGEDGTELPPGEPGEIYFEGGFDFEYLNDPDKTASSRHASGWKTVGDIGYVDEEGYLYLTDRRHHMIISGGVNIYPQEAENLLVTHPKVMDAAVFGVPDDEMGQRVKAVVQTVDPADATPEFADELLAWLRDRLAHYKCPRSISFEAQLPRTDTGKLYKQELIARYSR

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Crispr_ID: NZ_CP045325_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045325_2

215977-216127

Orphan

Consensus_repeat	Method
GCCACGGCGGTGCTCTCGTCGCCG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_CP045325_2

>merge|NZ_CP045325|2|215977-216127|CRISPRCasFinder
GCCACGGCGGTGCTCTCGTCGCCGATGAGGCGCAACCGGGCGGTGGAATCGTTGACTGCGGACGCCACGGCGGTGCTCTGGTCGCCGCGCACCGTGATCTGGGCGCGAGACCCGTTGGTGGCCAACACGGTGGCGTCGTTCTCGTCGCCGG

>NZ_CP045325|2|2|215977-216127|CRISPRCasFinder
GCCACGGCGGTGCTCTCGTCGCCG	ATGAGGCGCAACCGGGCGGTGGAATCGTTGACTGCGGAC
GCCACGGCGGTGCTCTGGTCGCCG	CGCACCGTGATCTGGGCGCGAGACCCGTTGGTGGCCAAC
ACGGTGGCGTCGTTCTCGTCGCCGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045325.1\|WP_152514988.1\|208381_209632_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	unknown	unknown	gnl\|CDD\|366703
NZ_CP045325.1\|WP_152514997.1\|231048_232878_+\|phosphoenolpyruvate-carboxykinase-(GTP)	unknown	unknown	gnl\|CDD\|235256
NZ_CP045325.1\|WP_152514993.1\|223781_226754_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP045325.1\|WP_152514994.1\|226824_227541_-\|NYN-domain-containing-protein	unknown	unknown	gnl\|CDD\|350235
NZ_CP045325.1\|WP_152514984.1\|205431_205818_+\|hemophore-related-protein	unknown	unknown	gnl\|CDD\|374603
NZ_CP045325.1\|WP_152514995.1\|227537_228323_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
NZ_CP045325.1\|WP_152514989.1\|209650_210817_-\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|223469
NZ_CP045325.1\|WP_173012153.1\|205902_206571_+\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_CP045325.1\|WP_152519440.1\|228562_229483_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|206686
NZ_CP045325.1\|WP_152514998.1\|233044_233275_+\|antitoxin	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514986.1\|206586_207942_+\|HAMP-domain-containing-protein	unknown	unknown	gnl\|CDD\|223715
NZ_CP045325.1\|WP_152514990.1\|210894_212046_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|279875
NZ_CP045325.1\|WP_152519441.1\|233261_233609_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
NZ_CP045325.1\|WP_152514981.1\|201014_201506_-\|XRE-family-transcriptional-regulator	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514999.1\|233710_235234_+\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|236215
NZ_CP045325.1\|WP_152514982.1\|201502_204430_-\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_CP045325.1\|WP_152514996.1\|229488_230853_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152514987.1\|208026_208395_-\|DUF3054-family-protein	unknown	unknown	gnl\|CDD\|378616
NZ_CP045325.1\|WP_152514992.1\|217606_223588_-\|tandem-95-repeat-protein	unknown	unknown	gnl\|CDD\|225926
NZ_CP045325.1\|WP_152514983.1\|204696_205242_+\|hemophore	unknown	unknown	gnl\|CDD\|275323

Protein	Function_ID	Function_description	E-value
NZ_CP045325.1\|WP_152514988.1\|208381_209632_-\|peptidoglycan-DD-metalloendopeptidase-family-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	5.74365e-14
NZ_CP045325.1\|WP_152514993.1\|223781_226754_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	1.77834e-138
NZ_CP045325.1\|WP_152514994.1\|226824_227541_-\|NYN-domain-containing-protein	gnl\|CDD\|350235	cd10911, PIN_LabA, PIN domain of Synechococcus elongatus LabA (low-amplitude and bright) and related proteins. This subfamily contains Synechococcus elongatus PCC 7942 LabA which participates in cyanobacterial circadian timing, it is required for negative feedback regulation of the autokinase/autophosphatase KaiC, a central component of the circadian clock system, and appears to be necessary for KaiC-dependent repression of gene expression. This subfamily belongs to the LabA-like domain family which includes the N-terminal domain of limkain b1, a human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Also included in the LabA-like domain family are human ZNF451, uncharacterized Bacillus subtilis YqxD, uncharacterized Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously Pseudomonas putida S16 NicB , which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	2.22829e-06
NZ_CP045325.1\|WP_152514984.1\|205431_205818_+\|hemophore-related-protein	gnl\|CDD\|374603	pfam16525, MHB, Haemophore, haem-binding. MHB is a coiled-coil molecule that binds free haem in mycobacterial cytoplasm to deliver it to membrane proteins for shuttling through the membrane.	3.5727e-37
NZ_CP045325.1\|WP_152514995.1\|227537_228323_-\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	1.26748e-86
NZ_CP045325.1\|WP_152514989.1\|209650_210817_-\|flippase-like-domain-containing-protein	gnl\|CDD\|223469	COG0392, COG0392, Predicted integral membrane protein [Function unknown].	2.61037e-43
NZ_CP045325.1\|WP_173012153.1\|205902_206571_+\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.48516e-81
NZ_CP045325.1\|WP_152519440.1\|228562_229483_+\|hypothetical-protein	gnl\|CDD\|206686	cd01899, Ygr210, Ygr210 GTPase. Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.	0.0017184
NZ_CP045325.1\|WP_152519441.1\|233261_233609_+\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	8.03134e-32
NZ_CP045325.1\|WP_152514986.1\|206586_207942_+\|HAMP-domain-containing-protein	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	4.00981e-43
NZ_CP045325.1\|WP_152514990.1\|210894_212046_+\|AI-2E-family-transporter	gnl\|CDD\|279875	pfam01594, AI-2E_transport, AI-2E family transporter. This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation. TsqA belongs to the AI-2 exporter (AI-2E) superfamily.	1.84455e-57
NZ_CP045325.1\|WP_152514999.1\|233710_235234_+\|AMP-binding-protein	gnl\|CDD\|236215	PRK08276, PRK08276, long-chain-fatty-acid--CoA ligase; Validated.	0
NZ_CP045325.1\|WP_152514982.1\|201502_204430_-\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	4.65724e-136
NZ_CP045325.1\|WP_152514997.1\|231048_232878_+\|phosphoenolpyruvate-carboxykinase-(GTP)	gnl\|CDD\|235256	PRK04210, PRK04210, phosphoenolpyruvate carboxykinase (GTP).	0
NZ_CP045325.1\|WP_152514987.1\|208026_208395_-\|DUF3054-family-protein	gnl\|CDD\|378616	pfam11255, DUF3054, Protein of unknown function (DUF3054). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	9.33774e-25
NZ_CP045325.1\|WP_152514992.1\|217606_223588_-\|tandem-95-repeat-protein	gnl\|CDD\|225926	COG3391, COG3391, Uncharacterized conserved protein [Function unknown].	7.26178e-22
NZ_CP045325.1\|WP_152514983.1\|204696_205242_+\|hemophore	gnl\|CDD\|275323	TIGR04530, hemophoreRv0203, hemophore, mycobacterial-type. Members of this family, including Rv0203 from Mycobacterium tuberculosis, are secreted heme-binding proteins used in heme acquisition. Such proteins are called hemophores. Members have a cleavable N-terminal signal peptide, and a mature region just over 100 amino acids long with a pair of invariant Cys residues. An unrelated hemophore, HasA, occurs in Gram-negative pathogens such as Yersinia pestis. [Transport and binding proteins, Other].	1.59488e-40

>NZ_CP045325.1|WP_152514990.1|210894_212046_+|AI-2E-family-transporter
MSAGPSLDPLADESVTPLVRKTAAWAWRLLIILAAVVALGWLILRLEILFVPVALATIVAALLMPVVDFLDRRGAPRSGAVALVLLSGFAVFGGLLAFVITQFIEGVPALAGQVSTSIEGVGAWLTDGPLKVSEQQINQFRDSALEALRDNQERLTSGAVSTAATVTEIVTGALLMLFTLIFLLYGGRNIFTFVTGVVPTGVRARVRNAGRAGFHTLIGYVRATFLVAAVDATGIGLGLAIMGVPLALPLASLVFMGAFVPLVGAVVTGFLAVIVALIAKGWIYALITLGLIIAVQQLEGHVLQPLVMGRAVSIHPLAIVLAIAGGAVLAGIVGALLAVPVLAFLNSAVRVLLADDPVAEEEAQEADDAPVIEAEPDDVEQLE
>NZ_CP045325.1|WP_152514989.1|209650_210817_-|flippase-like-domain-containing-protein
MSHDAPASGSPAGAANPERSRGKYWWLRWALIALALVVLTVELALVHDQLAKAWKSLYSANWMWVLAAVVAAMASMHSFAQIQRTLLRSAGVHVHQWRSEAAFYAGNALSTTMPGGPVLSATFIYRQQRMWGASPVVASWQLVMSGALQVIGLALLGLGGAFMLGASKNPLSLIFSLGGFVALILLAQAVASRPELIDGIGVRLLSWFNSVRGKPADTGLTKWRATLVQLESVQLGRRDLGEAFSWSLFNWVADVGCLLFACYATGGHPSVAGVTVAYAAARAVGSIPLMPGGLLVVEAVLVPGLVSSGMSLASAISAMLIYRLVSWIFIAAIGWVVFLIMFRTEKDLDPDRDPANPDATPLRSTDTHLPLLFSPDPEAPHPPGQPGP
>NZ_CP045325.1|WP_152514988.1|208381_209632_-|peptidoglycan-DD-metalloendopeptidase-family-protein
MQIRPLIAAASLTTLMLCAACATDPETKNAGTTAQATPPPPAAADSTPPPLPGPAVLTPVVGRVLAAPIPVPATDGKIHLAYELVLTNTTPQDVTLTGVDVRAGDRTLLSLPGERLTYWTRLAGNPVPTTTLGPAQTGYVWLDVAVDPDETVPAELSHTVAISVTDPSPPLIPASLTENIAPVTVQTRQPISIAPPLKGPNWLDGDSCCDMSAHRTALNPIDGEIWAAERFAIDYVQLGPDGRLFTGDETQLDSYPYVGSDVVAVGEGPVVSVVDGLPEQVPGTAPTDLPLEEYGGNHVVQDLGGGNYAFYAHLQTGSVQVEPGDHLSTGQVLGALGNSGNSDAPHLHFHVMSTPDPLRSNGLPFVFTDFRLDSRSTGDLDALLEGKPAELEPGFAPRDESGTSPLVYDVMTYAES
>NZ_CP045325.1|WP_152514987.1|208026_208395_-|DUF3054-family-protein
MPKADRSTAVKALAADAVCVVVFCTIGRRSHAEGLTVAGIAETAWPFLAGTAVGWLLAQAWRRPIAVIPTGLAVWLATVVVGMLLRKATGQGTAASFIVVASLTTAVLLLGWRAGARAVSRR
>NZ_CP045325.1|WP_152514986.1|206586_207942_+|HAMP-domain-containing-protein
MTRPKLPRFLRSASLRTRVAIASAAAAAAVVAAFTILTSVVLANNDATQLDRRLDAIVDASMFPEELSDPRRGVLTTGRDRTSGQVVFQRGFQLPPLPPGTETAFVNGVEYRVRTVPVEQDGGLLMSIGIRADSVLLNRARIPLYIAVGVVTVLIAAGLGWLLAGPAIRPLRKLTENTKRLGKDAEDIPAVHGVREAEDLSEAMSAMLSRLAAAQRATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHNLPDDERDEVVADLSRAQRRVEGIITALGQLASGQLAQVEDREVIDLTDMLDRVARENMRGANQVQIDVVLDDDLGTLLGWPSGLRLAVDNLVRNAVTHGQASRIVLSSHRHGGVVTIVVDDNGRGLPADEHETVLGRFSRGSNAAPGGSGLGLALVAQQAALHGGTIELSDSPLGGLRATLTVSTAPNESWTPPNEI
>NZ_CP045325.1|WP_173012153.1|205902_206571_+|response-regulator-transcription-factor
MVDDDPDVRTSVARGLRHSGFDVRVAATGREALRLLSSEPHDALVLDVQMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLHALLRRAHHSDPGSDTLTVGSLTIDTARRLVFVAGERVELTKREFDLLAALAENAGVVLSRQRLLELVWGYDFDVDTNVADVFVSYLRRKLERDGLPRVIHTVRGIGYVLREDP
>NZ_CP045325.1|WP_152514984.1|205431_205818_+|hemophore-related-protein
MLFSAPTVRRAVAGALGAGALGATLFGVLPAASAQPAPPNCTAADFAGVASGVSAASSAYLFTHPDVNDFFTSLHGLPREEIKTRVMDYMNAHPQERDELTAIRQPLVDIKNRCGYAFADAGDPDMPE
>NZ_CP045325.1|WP_152514983.1|204696_205242_+|hemophore
MDAPKTFIAPFVRTALGAVAAGGAVTLALVTGPAAGAAPDPCAASSVAKTVGAVATNTGVYLAAHPETDQALTAISQQPPGPQSVAMLKAYFDSNPEVATDMQRLQQPLATLSGRCRLPVTLPQMLGLLQSVQQGQGQSVQQGQGQGLPAQLPATQNVGAETTPAPGARGAVSSEARGAVS
>NZ_CP045325.1|WP_152514982.1|201502_204430_-|MMPL-family-transporter
MMRVSSNLRRFRWAVFAVWILLLVPSVHLALNQSGNLTGGGFEVEGSQSLYVQRQLEAQFPDQGASPLALVADPRPDASFDDMNEAVAFLERVAAEVPSVTVMPNPQQPPPQPDRPYVLTLQISFDNTGAVDIANQLREKVGIDGEDAGEMDNGKVRLYVIGQGALGAAATLATKNDIAQAEKWNFPIVLLILLAVFGSLAAAAMPLLLGICTVAVTMGLVFLLSMHMTMSVFVTSTVSMFGIAVAIDYSLFILMRFREELRAGREPQDAADAAMATSGLAVVLSGLTVIASVTGLYLINTPVLQSMATGAILAVAVAVLTSTTLTPAVLATFGRRAAKRSSYLHWGRRVEATQSRFWTRWTGWVMRRPWASALAAAALLLTLAAPAFSMTLGNSMQRQFDPTHEIRGGVNAAAVALGPGALGPVRVLVTFPDGNAASAPAKEPLLNAVRQKMTEAPNVVSVTPAVFGNDYRSALLSAVLSVDPEEMGARDTVDWMRDQLPAVAEGQALVNVGGPTALIKDFDDRVAKTQPLVFGFVALIAFVMLLISIRSVFLALKGVLMTVLSVAAAYGSLVVVFQWGWLSDLGFKQLSSLDSTIPPLVLALTFGLSMDYEIFLLTRIRERFLQTGNTRDAVAYGVSTSARTITSAALIMIAVFIGFAFSGMPLVAQLGVASAVAIAVDATVVRLVLVPALMAMFDEWNWWLPRWLDRILPSVDFEKPLPKADIGDLVIIPDDISALAPSGADLRTVVKSAAKLKTLAPQAITVADPLAFSGCQPCAKSMGGRLVEKRTPVAVGNRAHGKTVAVKLPKHPVTMWRGRLDVALDALGVQAGGPDGGSPLQRTDPMETTNVLLPTGDRLQIPTGAETLRLKSFLIMARNNARDYTELADLVDAMDTQTAAEVLTGMDRYYSGPPAGAQRANTLNGHWVATQLVRRLADPQPSDGPDFTREGAEAEWARVRQRCLTVAVAMLEEAR
>NZ_CP045325.1|WP_152514981.1|201014_201506_-|XRE-family-transcriptional-regulator
MTVTGEVRGSNRDAASPPPVDTRPVEFWPTAAIRAALENDDLSVWQRIVVAIKRDPYGRTARQVEEVLETARPYGVSRAMSEVLVRTREHLEANECAEVAKHVHLLLERSGLGEQEFASRIGVPAEDFATYLQGSVSPPASLMIRMGRLSDRFARMRAQRADQ
>NZ_CP045325.1|WP_152514992.1|217606_223588_-|tandem-95-repeat-protein
MSKQRLGQAFVSAGSTTRRSSRSAAECIGRVGALAASLGVGAVLFAAPWTAAADAEGSSGSGDTSSTSEAGSTESTESSSTAQATDDSTGDSSAGETESDDAEPESSSDDGDLEAELTEELGEELDDIEDDTDSEEEDGSSSGDGDAPVDLDDVTAADTVAEVVTVEEDVDSGGGSGPVESESEPVVDVDAAVPAAPEVLPESAPVEAMMIEVEETAPSRSSYTSASVMSARTSTAEITEAPAKALQAQPGTFLEVASSMLSAVIAPFVTTPAAPAAPSAQPLMWGVLSWVRRELDDTFANFSISIGGRQIVQNGTAYATSQGFGSFAIAHGENAVASASGLFNVAIVRGDDSTATSEGNFTRVRVRGDDNTAGADGPGSRASIYGDQNTAETTGAYTSIYVRGVGNAVTGTGDGTRATVTGDDNDATVLATNGSRAQITVRGDENSATASAEDDSTALVRIIGDGSTAVADAEADGYAAARITGDSNVASSDAMGETSIVRITGDDNAAWATASQARAEATVFGDSNFAEATDGNAVISGDGSIADADGPGSVARVWGDGSKASALGEDNTAFVWGDDSRAIAGPGTGNTAISLGNNLIADTGPGDGNTVYGQPFDPENQAPVAGAPGAQTVDPQTGTVTGTLGFTDPDSDTLTYSVTTDPANGSVTVNANGTYTYTPATRPDFGDPDGADSFTVTASDGQATATATIDVPVTAQPEPGNQAPVAGTPGEQTVDPETGTVTGTLGFTDPDGDELTYTATAPGNGSVTVNTDGTYTYTPATRPAAGEPNGTDAFTVTATDPAGLSASTTIDVPVTALPQPGNTAPVANPDTYSVDEDTVLVVTGPGVLGNDTDAESDGLTAVLSAGPVNGSFVLNPDGSFTYTPDSGYTGADSFTYTATDGALVSETATVTITVNPAVVDPPNTVIGTVDVGENPNAVSVTPDGTRVYVVNGGNLFNEDNASVTVIDVSDPANPTVLQTIPFDIYNPREIEISPDGLRAYVAYDNVVGGNGHLLVIDTDPASATYNTVIGDPIEVGDGPTDIEFTPDGTRAIILNQSSLDVVILDTDPTSASFHTLIGTPIRVANSSPRALALTPQGSRAYITIPRSGADTVVVLDINPDSDGYGTLIGDPIAVGDSPDDIEIAPNGARAYVVNAGDDTVSVIDTNPLSATYNTVIGNPIPVGDLPQSLVFTPDGTRAYVANGFDGEVVVIDTDPSSITFNFVIGEPIGVGARPDALAVSADGTHLYVVNDNDETVSVIYLGPSADPYNNAPSAGEDTFITNENAAVTGNVLANDFDVDGDSLTAELVTGPANGTLSLSPDGTFTYTPSHGFAGTDSFTYAVSDGALTDTATAAITVNAVGGDPVALGTVELPGELVGPLVIGADGLAYQTTETDGVVYVTVVDPSDPTSAITVELPGSATGAVQFGTDGTAYQISTAADVTHVAVIDPSAPAAATILEVPGSFEYTVFDGDTTYLVTGTGSTATHVTVIDPTAPTGAVTVDLTGEPADPLVIGPDGLAYQTTRSTSGGDDITHVTVIDPANPAAAITIELPGFTSEPVVFGPGGGYQTSYSGSFSSGYLTHVTKFDLGTLANPTTIDLTEDPDGSVMFGPEGTGYQLHGDFSRSYVTLIDPQDFTNPVTITLTGYRTEEVTFSDTGDAYVTSRTGTTTTHVTVIDPTDPTNATVIALPGTHDEPVAFFPDGTAYQFSETRTPGTDEYVTHLTVIDPADLTNYTTVDLAGQQILTRVIGADGTVYQRLRTIDTSGDEFFHVAVIDPANPTTPTVIDLPGYPVGELLTGGDGTLYQTSYSGVTSLYTVHVTIIDPEDPANPATVERTQYDPFFNYSLTNGYDPGLRVGEDGTAFLTNTATDLDGIDYPSATRVTVIDPAEPENAITIDVAGNPDGAVVIAPDGTAYQTVGTNNREFIPTWFTHVVVIDPEDPANPVVVDLLGQAVGPVTIGADGVVYQLTETVEDGVRNRQLTTIGVAGSAIDV
>NZ_CP045325.1|WP_152514993.1|223781_226754_-|MMPL-family-transporter
MFAWWGRTVYQYRYIVIGVMVALCLGGGVYGISLGQHVTQSGFYDEGSESVHASLVSDEAYGRDRTSHVVAILTPPDGEKVTDPQWMEKVTGELNDLVEEHPDQIVSWVGWLRAPDTDSAQVQQMKTADDSKTFISIPLKGDDDDTILKNYQAIEPDLKKVNDGDIQLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGGVVAASLPAIIGGLTIAGALGVMRFAAEFMPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTIMTSGRTVMFSAVIIVASSLPLLLFPQGFLKSITYAIIASVMLASILSITVLAATLGILGRNVDALGVRTLLRVPFFRNWKPMNWWLNWLADRLQKTKTREEVEKGFWGRLVNVVMKRPIAFAAPILIVMILLVIPLGQLSLGGISEKYLPPDNSVRLAQENFDQSFPGFRTEPLTLVVERDDGEPVTDQQMAEIRSKAMNISGFTDPDNDPTKMWQERSVQEGGSEDPSVRVIQNGLVNRNDAAEKIDELRAISPPRGITLSVGGTPALEQDSIHSLFDKLPLMVTVLIVTTTILMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVEGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALVLAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAIMKLLGDDCWWAPRWMKRLQDRLGLGETELPDERKRPSVRESGEPSQPAEPAHPEALVGAGGPPVAVSGRVQPHDPTHPGPGVPGRGTPPRPSGPSAAGTSRLPSAPPRPAPAEEPQTTRLSIAKDAVRNAVTNATAVTQRTPRATPPPAPKREDREIESWLGDLRGTGAAPVAPQPKPPSAEPTRAMPEPGGNEPTTAIPAQREPRPQQDDSAEETRAIPTARRGDAEAATEKLNTRGDDERQRRGGSSGVSAQELLRREGRL
>NZ_CP045325.1|WP_152514994.1|226824_227541_-|NYN-domain-containing-protein
MSVTENIPDMSADGTAPGDDAGAPGTPTASRVLLVWDAPNLDMGLGSILGGRPTAAHRPRFDALGRWLLARTADLSAQHAQAGRSVALEPEATVFTNIAPGSADVVRPWVEALRNVGFAVFAKPKIDDDSDVDSDMLEHIALRRTEGLAAVLVASADGQAFKQPLENLAEEGVEVQVLGFREHASWALASDTLEFVDLEDIDGVFREPLPRIGLDSLPEQGAWLQPFRPLSSLLASRV
>NZ_CP045325.1|WP_152514995.1|227537_228323_-|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MSDHGRMHAPGPDVADELASSGSVAPGQDAPAHGHRRVTSFRARRSTISDRQQAIWDERWPQLGTEARHGESPAPLLDTDAWFGRQAPLILEIGCGTGTSTLAMAQAEPDLDVIAVEVYRRGLAQLLSAIDRAEVTNIRLVRGDGVDVLTHMVGPDSLTGVRVFFPDPWPKARHHKRRLLQADTMALIADRLRPGGVLHAATDHLGYAEHIAEVGDAEPRLRRIDRDTAELPISVSRPVTKYERKALAGPIVTELLWERIP
>NZ_CP045325.1|WP_152519440.1|228562_229483_+|hypothetical-protein
MGTVESRVRAAVRVAVTGRQGVGRSQVATALSGAGLVVTPDVDGADAHVRVIAEALKPEDERALRDRSVPAVVVLNKADLAGADPGGPLAGAERAAARLAAERGLPVVPMVASLADVALGDEDMAALRALARCAADMTSTDAFVAAPHDVPGAVRSRLLVMLDRFGLAHAILAVAEGAAAGPVAQRLRELSHLDRVLDRLTAAAAPVRYHRIAAALVELRILAACSGDEQLAAFCCADDTVLAVSAAAVDVVEASGGSVAGGDGPEDHLKRALRWRSYGQGPVSPLHQRCADDIVRGSLRLLDRVR
>NZ_CP045325.1|WP_152514996.1|229488_230853_+|hypothetical-protein
MTARTTVVHVTGPPRAGVSSVAACLRDRMPDVTVVDAADPARTRDVPDVPDVVVFVVSAVAPVTESDCVLAVSACRSTDAVIAVLTKIDDHRDWRGVLATSRQRLADCAARFASVRWVTAAAAPRLGEPAVDDVVAALTAALSDPDLARRNTLRRWEARLGAALTGMHAADSGHLARVSALRAHRDTLVRNHLPSGAVSVRHPMQRARLELASAARQRCVTLRTELLEAAAETTAVAEIEERVRRRCGEVIAEVDEQTERRLHDLASELGAGLPEPSAVAEVCLGDPPLRQRRLEARVTTVLGAGFGFGAGLVVARWVTGLAPGLTVAGALVGAAVGLALTLWVVAARALLYRRAVLAQWIGEATGTVRTALDERIASRLLAAEAAVTTARLAQRAGMAERVAECDAQLRGHVLAARRAQALREASEPGLARVLTVVRDGLREPDSTRTLVTDR
>NZ_CP045325.1|WP_152514997.1|231048_232878_+|phosphoenolpyruvate-carboxykinase-(GTP)
MTAATIPGLDSAPTKHEGLLAWVREVAELTQPDRVAWADGSDEENQALCDQLVEAGTFQKLNPEKKPNSYLALSDPSDVARVESRTFICSQREIDAGPTNNWMDPAEMRGLMTDLYRGSMRGRTMWVVPFCMGPLEAEDPKLGVEITDSEYVVVSMRTMTRMGRAALDKMGTDGFFVKALHSIGAPLEPGEKDVPWPCNDTKYITHFPETREIWSFGSGYGGNALLGKKCYSLRIASAMAHDEGWLAEHMLILKLISPENKAYYIAAAFPSACGKTNLAMLQPTIPGWRAETVGDDIAWMRFGKDGRLYATNPEFGFFGVAPGTNWDSNPNAMKTIAAGNTVFTNVAKTDDGDVWWEGLEGEPDHLIDWKGNDYILRETETKAAHPNSRYCTPISQCPTLAPEWDDPQGVPISAILFGGRRKTTVPLITEARDWQHGVFIGATLGSEQTAAAEGKVGTVRRDPMAMLPFMGYNVGDYFQHWINIGKQADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWAIERIEHTADGKSTPIGIVPTAADLDLDGLDVDAADVDEALKVVPDEWRNELPLIEEWFEFVGEKLPTSIKDEFDALKHRLDEAE
>NZ_CP045325.1|WP_152514998.1|233044_233275_+|antitoxin
MKLSVSLSDDDVAVLDAYVKNAGLASRSAALQHAVRMLRHAALEHDYEAAWSEWSESEEAGLWAEPLDDGLGDAPR
>NZ_CP045325.1|WP_152519441.1|233261_233609_+|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MRRGEIWQVDLDPARGNEANKRRPAVIVSNDRANATAGRLGRGVITLVPITSNVANVYPFQVRLTAATSGLTALSKAQAEQVRSVSVERLLRRIGRVSPTELDQLDEALRLHLQL
>NZ_CP045325.1|WP_152514999.1|233710_235234_+|AMP-binding-protein
MQIRDTAVATPDKPAVIMYPSGTVVTFGELEARANRLAHLFRKAGLVEGDAVAILMENNAHMHAVMWAARRAGLYYVPINTHLTAAEAAYIIDNSAAKAIVGSAKLTDTLAGLADELPNGLPSLLLIADGTLQGWSSYPECVADQPDTPIDDEIEGDLLQYSSGTTGRPKGIKRELPHVPPSEAPGLMAALVSFWMHPDTVYLSPAPLYHTAPSVWSMQTQAGGITTVVMEKFDAEGALDAIAKHRVTHGQFVPVMFTRMLKLPDEVRKAYDVSSLERVMHAAAPCPVEIKKQMIDWWGPIVDEYYASSEAHGSTLITAEEWLTHPGSVGRPLAGAVHIVGEDGTELPPGEPGEIYFEGGFDFEYLNDPDKTASSRHASGWKTVGDIGYVDEEGYLYLTDRRHHMIISGGVNIYPQEAENLLVTHPKVMDAAVFGVPDDEMGQRVKAVVQTVDPADATPEFADELLAWLRDRLAHYKCPRSISFEAQLPRTDTGKLYKQELIARYSR

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Crispr_ID: NZ_CP045325_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045325_4

938237-938353

Orphan

Consensus_repeat	Method
CTCGCACTTTGCCGCAGCCAACGCAGTCTCAACG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045325_4

>merge|NZ_CP045325|4|938237-938353|CRISPRCasFinder
CTCGCACTTTGCCGCAGCCAACGCAGTCTCAACGCCAAGGTTCCGCGGTGGAATCGTTGAGGCTGCGTCCACGGCGGCGTCCACTCGCACTTTGCCGCAGCCAACGCAGTCTCAACG

>NZ_CP045325|4|4|938237-938353|CRISPRCasFinder
CTCGCACTTTGCCGCAGCCAACGCAGTCTCAACG	CCAAGGTTCCGCGGTGGAATCGTTGAGGCTGCGTCCACGGCGGCGTCCA
CTCGCACTTTGCCGCAGCCAACGCAGTCTCAACG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045325.1\|WP_152519500.1\|932037_932391_+\|nuclear-transport-factor-2-family-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152515585.1\|932400_932910_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|225113
NZ_CP045325.1\|WP_152515598.1\|949952_952331_+\|esterase-like-activity-of-phytase-family-protein	unknown	unknown	gnl\|CDD\|379191
NZ_CP045325.1\|WP_152519502.1\|942494_943193_-\|DUF4194-domain-containing-protein	unknown	unknown	gnl\|CDD\|372745
NZ_CP045325.1\|WP_152515586.1\|932914_933475_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_CP045325.1\|WP_152515596.1\|946705_948439_-\|AMP-binding-protein	unknown	unknown	gnl\|CDD\|235624
NZ_CP045325.1\|WP_152515592.1\|943252_944704_-\|DUF3375-family-protein	unknown	unknown	gnl\|CDD\|371764
NZ_CP045325.1\|WP_152515595.1\|946383_946686_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152515599.1\|952601_954185_+\|STAS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223732
NZ_CP045325.1\|WP_152515588.1\|934526_935414_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152515589.1\|935410_937738_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152515587.1\|933506_934400_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152515584.1\|931168_931927_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|235500
NZ_CP045325.1\|WP_152515590.1\|937893_938163_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152515597.1\|948896_949838_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP045325.1\|WP_152515583.1\|930110_931028_-\|zinc-binding-dehydrogenase	unknown	unknown	gnl\|CDD\|176203
NZ_CP045325.1\|WP_152515593.1\|944896_945478_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|188483
NZ_CP045325.1\|WP_152515591.1\|939136_942502_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|227250
NZ_CP045325.1\|WP_152515582.1\|928992_929997_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	unknown	unknown	gnl\|CDD\|274743
NZ_CP045325.1\|WP_152515594.1\|945521_946127_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102

Protein	Function_ID	Function_description	E-value
NZ_CP045325.1\|WP_152519502.1\|942494_943193_-\|DUF4194-domain-containing-protein	gnl\|CDD\|372745	pfam13835, DUF4194, Domain of unknown function (DUF4194).	1.56385e-34
NZ_CP045325.1\|WP_152515598.1\|949952_952331_+\|esterase-like-activity-of-phytase-family-protein	gnl\|CDD\|379191	pfam13449, Phytase-like, Esterase-like activity of phytase. This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.	8.69144e-43
NZ_CP045325.1\|WP_152515592.1\|943252_944704_-\|DUF3375-family-protein	gnl\|CDD\|371764	pfam11855, DUF3375, Protein of unknown function (DUF3375). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	6.74987e-108
NZ_CP045325.1\|WP_152515586.1\|932914_933475_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.12199e-09
NZ_CP045325.1\|WP_152515597.1\|948896_949838_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	3.57997e-45
NZ_CP045325.1\|WP_152515599.1\|952601_954185_+\|STAS-domain-containing-protein	gnl\|CDD\|223732	COG0659, SUL1, Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism].	4.48333e-129
NZ_CP045325.1\|WP_152515585.1\|932400_932910_-\|GAF-domain-containing-protein	gnl\|CDD\|225113	COG2203, FhlA, FOG: GAF domain [Signal transduction mechanisms].	1.38287e-06
NZ_CP045325.1\|WP_152515584.1\|931168_931927_-\|SDR-family-oxidoreductase	gnl\|CDD\|235500	PRK05557, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Validated.	5.63331e-87
NZ_CP045325.1\|WP_152515596.1\|946705_948439_-\|AMP-binding-protein	gnl\|CDD\|235624	PRK05850, PRK05850, acyl-CoA synthetase; Validated.	0
NZ_CP045325.1\|WP_152515583.1\|930110_931028_-\|zinc-binding-dehydrogenase	gnl\|CDD\|176203	cd08241, QOR1, Quinone oxidoreductase (QOR). QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR acts in the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site, and a structural zinc in a lobe of the catalytic domain. NAD(H)-binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	2.84161e-44
NZ_CP045325.1\|WP_152515593.1\|944896_945478_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	1.23505e-12
NZ_CP045325.1\|WP_152515591.1\|939136_942502_-\|AAA-family-ATPase	gnl\|CDD\|227250	COG4913, COG4913, Uncharacterized protein conserved in bacteria [Function unknown].	1.09767e-106
NZ_CP045325.1\|WP_152515582.1\|928992_929997_-\|TerC/Alx-family-metal-homeostasis-membrane-protein	gnl\|CDD\|274743	TIGR03718, R_switched_Alx, integral membrane protein, TerC family. Rfam model RF00080 describes a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the larger group of TerC homologs (pfam03741), this subfamily contains TerC itself from Alcaligenes sp. plasmid IncHI2 pMER610 and from Proteus mirabilis. It also contains the alkaline-inducible E. coli protein Alx, which unlike the two TerC examples is preceded by a yybP-ykoY leader.	4.6041e-132
NZ_CP045325.1\|WP_152515594.1\|945521_946127_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.23717e-07

>NZ_CP045325.1|WP_152515590.1|937893_938163_-|hypothetical-protein
MSSSELSDVAWDLVEHCRAALSIPELNTAFVRLGVGDYSEAMVVALKSLTRSAGPPLTDQLLARLTSVEQTYHVEREFSELLAAAPRSG
>NZ_CP045325.1|WP_152515589.1|935410_937738_-|hypothetical-protein
MSVLDAFLSTWSNARATFGEGVPQPGTGYDQSASLSTLKSDLDQAAPGTHWSGGAATVYGNANTEHQRVIGELGGLDRRLAVKVDQSAQIVAAGRQDLDAVRKWVLDAAASVPKNRAGEQMLVPIVSRGLGRLNDIVTRRNGELSTVGGDIRTIGSEYQALGTDQKFAADGGHGEDDGEDAPEETSAAEQGRQDSEALQDGTLTDEQRERLAESTTLTAQQQSALDEGNLTMPPEQMSYLQGFSQAFGDKTPSEIKADMQAAGPDGARVADAFQLASNPTITTGLPGTDPPSVEWPAAGSEHALPDGVRQVLDGPALTQPFSDTIRDDNGNVIVHGEPTGPLQPTKGLDDLADIVQSGNRDLQVGTDLDRGLMAKGQEMLEQSNRLPIEQAPGPGFGPLDHGPRWYHEHVDPTLQNMFNAVNADDVVVHDVVTGPGGGEFLDDLTKHQWQDDGLAAGGLFDWVAETAQDDPTGRAASTAHALAEYTSGHQRQLLNLAGADGQSLGQVNPELTRDLSRVFAPYLDDMVGNNIDGTNDRYFPPLDGAEEQPLKTRALMSVMYSDSSENGAAATLFDGVGSKVEAYVHSAGASTADQDPTLAHADMKAAGRLQAALDLGSFDEAYDRLSNAQQAVHESYARRAMLFDTVAGLGSEVPGGAAVSPTLKELFLGPPPAVDAITPTATPQSSLPIQIMMAEELLNHELGNTEIREWLQQRSGEDGRLQVPDDDADPKIYNEFADNIKSLFEYVDGANSLMETYWETYTGGYHQADPRIAGE
>NZ_CP045325.1|WP_152515588.1|934526_935414_-|hypothetical-protein
MTRKTLACSIFVACIAALTQGCGSGGQPPTGQGSSAEEFANWPSALDNFRFHWTSDPEVSLTTGFAVPIRAYFESWYIASWTNNAEAVYPGFLRATSESDDLDGDYLGQLAWIRPLNGRPGYPTEPVTPYGFMPVHIQSVEPIDNGLRVTVCEGQYAAVLPSDSAPNQMVSLAANKVTGELRDPLDTVLVNRIELTQNHPRIPAGASDVDTLQEGPAPAPVGDVFGHWFITGASSSLWGPVDADPPDFFVTPDMRRQCQEAMPDSPEKQIEMANGFKDSPPPHGQPIPGWPLAPQ
>NZ_CP045325.1|WP_152515587.1|933506_934400_-|hypothetical-protein
MIRRTSAFAIATLVAMTSAACGTEAGRDPATNPGLPAETDVANWPNSLAEFRFHWSSTAGIDVALGAAVPIRAYLESWYIASWTNDPENVYPGFLRATPESADLDGNYLGQLAWIRPLNGAPSYPVDPATPLGYMPMHIQSVDAVASGLRVTVCLGEYSIYFASDSSAGKLVSVAAEKSTAQLADPLDTVRVKRIELTKTDPRIPAGASDVDTPQEGPAPAPVGDVFGHWFITGASSSLWGPVDADPPDFFVTPDMRRQCQQAMPDSPEKQIEMATGFKDTPPPHGKPIPGWPLAPQ
>NZ_CP045325.1|WP_152515586.1|932914_933475_-|TetR-family-transcriptional-regulator
MARPPKFDREEALGCAMKVFWEKGFDGTSISDLTAAMGISPPSLYAAFGDKQSLFDAAVDLYEQDAVLSPALKAATARDVAEQIFSRAVDLYTRPAHPRGCMVIADPTLQDRRRSGKDAIVRRLQRAKRTGDLPADSDPRALADYLDLVLRGMSSKARDGATRAQLRAAADVALAAWPAPTRNLAD
>NZ_CP045325.1|WP_152515585.1|932400_932910_-|GAF-domain-containing-protein
MTEHDDTTASHRPDATDGLASVAPGLEELAQQLNVKSVLVMRSEPDSMVVAATGGEATQHYTVGAAGKKAGDDQDRTPLYCERVVNSDEALFVRDSRTDAIFAGNEDETEFGLHNYLGLPVHDAEGNVVGTVCALDDTARDYSAEDQQKLAQLRSDVEALVKENPDALR
>NZ_CP045325.1|WP_152519500.1|932037_932391_+|nuclear-transport-factor-2-family-protein
MEENLLAVFNERDPQRRLEVIRRNYAPDVRWADGEETVTGQDRLHEKAQELLDGQLAGLGFSQSGPVYQAGNMGFLAWDVFPPGDQSGTPLVSGFDVALVENGVIAKLFTVVTTAPG
>NZ_CP045325.1|WP_152515584.1|931168_931927_-|SDR-family-oxidoreductase
MTHSPTLPLSGRRALVTGGSRGIGAGIVRRLVADGADVAFTYSTSAGAADNLVAELSTNGVKVVALQADSADAGAVQAALGETVHQLGGVDILVNNAGIASLAPLESLSLEEFDRMVAVNVRAVFVAIQAAVKHMTDGGRVITIGSVNGDSVPVAAGLSVYAMTKAAVAGLTRGLARELGPRQITINNLAVGPVATDLNPDEGDFADANRAQTALGRYGDTADVASVVSYLSRPEAAWVTGATWAVDGGYTV
>NZ_CP045325.1|WP_152515583.1|930110_931028_-|zinc-binding-dehydrogenase
MRAAVLEAVGETPHVKDFEEPGGQDIVTVTLAGCNPVDIVLASSDLLKPSVPLVVGQEGVGFTDDGTRVYFNSPPIPFGSWAERAAFDPDRAFPIPETVDDDLAVALGIAGLAAWLPLTRHAELSAGQSVLVLGAIGVVGSIAVQAAKILGAGRVVAAGRNKDALEKTRDLGADALVELGGDDDAQALKEEAGDGYDVVLDMVYGEPFLAALESSAPQATLVTVGEGAGGAPEVPFRSLMGRTHVGHNNNVMGNAVMRQGYQELIGLAEQKRITVETVRYDLEDAGKAWQAQTESPHVKIGIVPK
>NZ_CP045325.1|WP_152515582.1|928992_929997_-|TerC/Alx-family-metal-homeostasis-membrane-protein
MSEISGLTWGLTIGLVVVLLAVDLILAALRPHKVGFKEATAWSLFYIAVAIAFGVWFTVTYGSTLGTEYFAGYIVEKSLSVDNLFVFVIIMATFAVPEEHQHKVLTFGIILALIMRAIFIALGATLLSLFSFMFLLFGILLIWTAIQLFRHRDEDPDVENNIMVRATRRFLPVTETYDGGKLVTRVDGRRMVTPMMAVLISIGSVDLLFALDSIPAVFGITREPFIVFAANAFALLGLRALFFLVKGLLDRLVYLSTGLSIILAFIGVKLVLHWAHVDINPSIPEVDTYVSLGVIVVILTVVTVASLIKTRQDPTAKAHPGSLRASPPRDEDRH
>NZ_CP045325.1|WP_152515591.1|939136_942502_-|AAA-family-ATPase
MTEQFHLSRLQVINWGVFDGYHSIPFSSGGALIAGASGSGKSSLLDAISLGFLPFNRRNFNASGDNTAAGSSAGRRTVDKYVRGAWGQRSDGGTSRVMYLRGDGTAWSAVAVTYTGDTGRSVTGLVLKWLTGESRNDSSSRFVLGDGDLDIEDICNRWAAGRFDTGVFKEGDWRFTTKVESQYLAQLYATIGIRASDAAQQLLGKAKSLKSVGGLEQFVREFMLDEPDSLARLPEALKQIDPLVEARELLAVAQRKRKILGDIEAIQHRYASESSDLGIIDLVDAPMVRAFTDHVRVAQCPAQITELDTAIDQLDNEDEDVTRALNLAKAEADSINAQISGSSASIGPLQSQVAAAETEAEQVSRRRSAYEDLVLAQGLEVPGSAEEFWNLREELLTKAAELLARVERNREASTDAEYAQKAARIARDDAAKELRRVEQVGSALPEFALTMRDQVCAAIGVDASALPYVAELMDLRADQTRWRVAVEKVLRGVGLRLLVPDEHWAAVLRFVNETNMRGRLALHHVRVKSLGAEPAPLEPNTLAGKLFVVDPAHPCAAEAADVVAAAGDHLCVDTPDVFARFRRAVTDTGLYKDSDRLAVKDDRRPLKQSDYLYQGDVSAKINALTVDLAAAEDAYQSARRAADDIAAQRQQWRDRATAAKAICDQYPQWSQIDSETADGHADRLREQYELLLAEHPDLEALNARADECWEQIQKLMTRRGAIQTRREDLDTRRTRLLELSERLSPAFVSEPLTDLLRRYTAMVPVPLEVLEPEPHREALFAAIKREREQLRESRRRSYDELARILNTFDTTFPDAIPNDSSNFDERVHDYVALCRHIDERELPEAYERMMRLVTEQAPDAILTLHRVAEQEARRISDQIDRVNTGLGAVEFNRGTRLTLRATPRALAAVSELTEIVRAISRRIAEVGLGDKQAILDQYADILRLRNRLASTAPEDRAWTRDALDVRNRFTFDCAEWDIASEELIRTHSNAGDNSGGEQEKLMAFCLAGALSFNLAAPDSSDNTPVFAQLMLDEAFSKSDPQFAQQALQAFRKFGFQLVIVATVQNATTIQPYIDSVVMVSKTEATGRNARPVATVATRSIAEFGELRREMSVTAARVPAGV
>NZ_CP045325.1|WP_152519502.1|942494_943193_-|DUF4194-domain-containing-protein
MDTESIDYRGFSDLPQVDQNARPPAQRRPRFDGDVSELPDRACWALQHLLTRRYVSAENDADIYAWVLEYRNQLSVRLSELDLLLRVVDGTDVAFVEQARYESAKGIKLLRREPLGTYDSILALHLAQMMRAAGGQRVLISREEMHGLFSGVLNDTDRDAVTFTARIDAAIARLTGLEILRRSRDDEDSYTISPVISAIMTASVITELQQQFELLARGGAPADDTGEVELDD
>NZ_CP045325.1|WP_152515592.1|943252_944704_-|DUF3375-family-protein
MHDTAQPSVAELLDHNRDLQGSRAIRLLATHNLGLYATLMERHLADGVIPETDLVIRLERDLDDVGHPDGQSGLALIKSWASQGWLHRIVDERSDQNVCYLTQDARRALDFVRGMRRNDTIATGGSIHGIASRLKQVAVRVDNDPARIRKHIEAEIAALHSELDQLDAGERPDPDPTDCYDEARAIALQMERLITDIGQYGTMIEQATAALDEPIDTNTEYRDRQRQMYADYQAAWDSQGRDSHRAFLRMINDPDQRAEFEADVAAVADALPALDPALRKVMAGFFELVGHQIDEVERIQQRCAQRVKRFTAFGTLEQSRGVARQLNEALGSARALLKTSLTDSRLDLDVPLARHAISSVGALSFKIGDLSAPKPARPADGQVDLASFAALTTQVDAPAMSQMLNTALHRGPVSLPDAVALLESAYLGHVIVLWSWALKQPAAESVRESTTVRFRSLDGRDREIAVPKLMFTEPITALVGAST
>NZ_CP045325.1|WP_152515593.1|944896_945478_-|TetR-family-transcriptional-regulator
MSVSHSESKGLRERKKMQTRLAIRREAFRLFTEQGYAETTIEQIAAAAEVSPRTFYRYFGVKEALLLSDDHISPTVEAFANAPRHLSYVQAYHYAVNEVYGALSPEEREDAIAGQQILYQVPEARGLLYTAYLTLADLLTEALLRRPDGPADEAERRVMAGAIMGVLILTAQDTPLPEAAMDRALSILDSRLS
>NZ_CP045325.1|WP_152515594.1|945521_946127_-|TetR-family-transcriptional-regulator
MDERLSSGRHHLSPDQVAADQQKRLFKALAVVMGEKGYSNTTVGDLIKHARVSRATFYQQFESKQDCFMAGYARMQSNVLGGLRATPVSGSPMARFRAMLTNYLNFLAADPPTARLYLVEVYAAGPEALRRRMQLQQDFVAGVAEVFAARSKADRFACQALVAAISMLVTGALADGDAQAILALEKPLVEFTERALPASLH
>NZ_CP045325.1|WP_152515595.1|946383_946686_-|hypothetical-protein
MGDLQSIGHGGQPTPVVFRAVDPPQDVLVDLVALFPREPHSHGRYHPFGLQMHKVVRGELTRWGMCEQGHWWGLVSYPVSHGPKSDLVMHWIPAWMLKKA
>NZ_CP045325.1|WP_152515596.1|946705_948439_-|AMP-binding-protein
MPPIATSIPAALAARAQAQPDDVAYTFIDYEYDPAGAAESLTWSEVHERVQIVAEKLSKLGAPGDRAVILAPQSLDYVVAFLGAIQAGFVAVPLSMPMFRQHDERVSGVMADATPVAVLTTSDVIEDVRKYGQVESRSHAPKFIEVDTLDFDSPAKPPAPVALPKAGYIQYTSGSTRRPAGVVVTHQNIFENMEQILPDFFEAYDEPPADLTVVTWLPLYHDMGLLVGVFLGMRMGRSTVLMTPVAFMQKPARWIQQLALNPHTFTAAPNFAYELAVKRTKEEDLAGLDLSGVVVMINGAERVHGATVRRFNDRFGPYGLPEAAMRPSYGLAEATVYVTSSAGGRAPTSVRFDYDELAAGRAQPCAEGAGSEHIGLGVPRSTTVRVVDPQTRVEAPAGTIGEVWLHGPHVAGGYWHNPQLTEELFAGQLAQTSEGTPKGPWLRTGDLGVLFDEELFIVGRIKDLLIVDGRNHYPDDIEATVQELTGGRVAAVSVPDDPSEKLVVIAELKKQLDAEVLDSVKQQVTAAVSQTHSVRLDDLMMVGPGSLPLTTSGKVRRGTCVELYHSDGFRRLDAAPA
>NZ_CP045325.1|WP_152515597.1|948896_949838_+|diguanylate-cyclase
MTKVPVGEAMQRRLLVALLAILLVLYSAAVVQAPLLADTRGEWIGAGLCVVGLGAAIGAGTHGARYLVAVSCLCAAPVVTMLFHRLIVAQVWSLIPLMFAAVYVRTWHRPAVARIVAVTLSAAAVAALWLAPAPAPWLWSVSFPVCILGAAEVVGVLHAALFDAALRDPLTGVWNRAGVDRRAGELVDRARRRNESVAVLVLDVDDFKAVNDRDGHAAGDIVLTQLARRLVAQLPEQAVIGRLGGDEFVVVLSGVDEGSARQIAGDLRGTGPVHVTAGVAVGRPVDGDGFTELLVTADDDLYRAKRHRNPGLR
>NZ_CP045325.1|WP_152515598.1|949952_952331_+|esterase-like-activity-of-phytase-family-protein
MAGTNRGTARRAATAVAITAVVVAGCSTDNQDDAGDTAAPDTPRATSPIDFDLPAAQRYHRTATYPVHLNKPEGDSVDAETVAEISTVTPDGNTVIYTDAAAKRIGFVDVADPVNPVGQGTLSLEELGNADDQPTSVAAVADVVLVVIDTTGGDFANPSGRVDIVRVSDRTPVHSIDLGGQPDSIAISPDGSFAAIAMENQRDEEATPPGGEEGDLPQPPTGFLQLIDLAGEPNTWSARRVDFDVEAARSAGLDTPEDLEPEYVSINSRGQVALTFQENNGVAIIDGRTGEVTNIFSAGSESVEGIDTAEDGTIDQSGSISDTPREPDAIGWVGDDHVVTANEGDWKGGTRGWTIFDATTGEVVWDAGNSFSQLAVRTGLHIEGRAESKGPEPEGLAITEINGTPTALVASERSNFVAVYDVSDVTAPQFRQILPTTPGPEGVLPIPSRNLLVISSEADDAEAGVRASLNVYGFGDRFAASGGGDQSAASGGTPMFPSIVSGDVDGAPIGWGALGALSADPADENRLYTATDNAYGPARVLGIDLTQTPALIDTELPVTDNGEAVTLDVEGISARPDGGFVLGVEGEEGPGNELVIVAADGSVEKRVTLPADIADAMGGQGIEGVAVDGDAIWVALQRELETDPPGVARLGRYTPDSDSWEWFGYQLDTTDTEGDWIGLSEIAVYDGSLLVLERDKLNGPDARVKAIYRVALPEDAGVTSATEAPQVLPKTLARNLVPDLQATKGFVQEKVEGFAVAGNGNLYVVTDNDGLDDANGETQFLDLGPAATALGG
>NZ_CP045325.1|WP_152515599.1|952601_954185_+|STAS-domain-containing-protein
MTHEPAQQDLCARAKGAVLSTTSSEISPQQQQSVLGALRSPRRLRTEVLAGLVVALALIPEAISFSIIAGVDPRVGLFASFTMAVTIAIVGGRPAMISAATGAVALVIAPLVASHGLDYLIAAVILAGLLQLVLGGLGVAKVMRFVPRSVMVGFVNALAILIFLSQVPHLLGVPWLVYPMVAVGILVIVALPKLTTAIPAPLVAIAVLTVAAVLGGWNVPDVGDEGRLPSNLPSWLIPDVPLTMETLRIIAPYALAMAVVGLLESLMTAKLVDDITDTHSNKSREAVGQGVANMVSGFFGGMGGCAMIGQTMINVKVSGARTRISTFLAGVFLLALVVGLGDLVARIPMAALVAVMIMVSVATLDWHSISPKTLRRMPKSETFVMLATVAVTVATHNLAYGVAVGTLAAMVLFARRVAHFTEVVALDPAPADAPAETAADTRVYAVRGELFFASSNDLVYQFDYVGDPANIVIDMSDAHIWDASTVATLDAITTKYAAKGKSVTIIGMNDNSAERHARLSGQLSGAH

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Crispr_ID: NZ_CP045325_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045325_5

1463339-1463447

Orphan

Consensus_repeat	Method
GCCGCCGCCGGTGACCGAGGACGTCCCGCCGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045325_5

>merge|NZ_CP045325|5|1463339-1463447|CRISPRCasFinder
GTCGCCGCCGGTGACCGAGGACGTGCCGCCGCCGGTGACCGAGGACGTCCCGCCGCCGCCGGTGACCGAGGACGACCCGCCGCCGGTGGCCGAGGACGTGCCGCCGCCG

>NZ_CP045325|5|5|1463339-1463447|CRISPRCasFinder
GTCGCCGCCGGTGACCGAGGACGTGCCGCCGCCG	GTGACCGAGGACGTCCCGCCGCCGCCGGTGACCGAGGACGA
CCCGCCGCCGGTGGCCGAGGACGTGCCGCCGCCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045325.1\|WP_152515993.1\|1450536_1451400_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	unknown	unknown	gnl\|CDD\|178455
NZ_CP045325.1\|WP_152516001.1\|1464383_1464755_+\|DUF742-domain-containing-protein	unknown	unknown	gnl\|CDD\|283084
NZ_CP045325.1\|WP_152516007.1\|1471244_1471640_-\|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl\|CDD\|378915
NZ_CP045325.1\|WP_152515996.1\|1456125_1456539_-\|TIGR03667-family-PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|132706
NZ_CP045325.1\|WP_152516004.1\|1465965_1466442_+\|Rrf2-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|236820
NZ_CP045325.1\|WP_152516005.1\|1466438_1467656_+\|hemin-transporter	unknown	unknown	gnl\|CDD\|237337
NZ_CP045325.1\|WP_152519558.1\|1458704_1459406_+\|FCD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224715
NZ_CP045325.1\|WP_152516003.1\|1465315_1465870_+\|pentapeptide-repeat-containing-protein	unknown	unknown	gnl\|CDD\|224276
NZ_CP045325.1\|WP_152515999.1\|1459510_1461031_+\|cytosine-permease	unknown	unknown	gnl\|CDD\|271404
NZ_CP045325.1\|WP_152516002.1\|1464735_1465311_+\|ATP/GTP-binding-protein	unknown	unknown	gnl\|CDD\|225138
NZ_CP045325.1\|WP_152515992.1\|1449623_1450064_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152516008.1\|1471689_1472256_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
NZ_CP045325.1\|WP_152516006.1\|1468474_1471192_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NZ_CP045325.1\|WP_152519560.1\|1467652_1468129_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|379883
NZ_CP045325.1\|WP_173012174.1\|1452812_1456076_+\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
NZ_CP045325.1\|WP_152515994.1\|1451532_1452732_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
NZ_CP045325.1\|WP_170311197.1\|1458368_1458521_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_173011981.1\|1463962_1464376_+\|roadblock/LC7-domain-containing-protein	unknown	unknown	gnl\|CDD\|224929
NZ_CP045325.1\|WP_152515997.1\|1456562_1457204_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380311
NZ_CP045325.1\|WP_152515998.1\|1457208_1457673_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	unknown	unknown	gnl\|CDD\|223297

Protein	Function_ID	Function_description	E-value
NZ_CP045325.1\|WP_152515993.1\|1450536_1451400_+\|MaoC-family-dehydratase-N-terminal-domain-containing-protein	gnl\|CDD\|178455	PLN02864, PLN02864, enoyl-CoA hydratase.	2.45686e-66
NZ_CP045325.1\|WP_152516001.1\|1464383_1464755_+\|DUF742-domain-containing-protein	gnl\|CDD\|283084	pfam05331, DUF742, Protein of unknown function (DUF742). This family consists of several uncharacterized Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	1.23842e-26
NZ_CP045325.1\|WP_152516007.1\|1471244_1471640_-\|nuclear-transport-factor-2-family-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	2.6369e-10
NZ_CP045325.1\|WP_152515996.1\|1456125_1456539_-\|TIGR03667-family-PPOX-class-F420-dependent-oxidoreductase	gnl\|CDD\|132706	TIGR03667, Rv3369, PPOX class probable F420-dependent enzyme, Rv3369 family. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN. [Unknown function, Enzymes of unknown specificity].	2.38758e-49
NZ_CP045325.1\|WP_152516004.1\|1465965_1466442_+\|Rrf2-family-transcriptional-regulator	gnl\|CDD\|236820	PRK11014, PRK11014, HTH-type transcriptional repressor NsrR.	9.04093e-29
NZ_CP045325.1\|WP_152516005.1\|1466438_1467656_+\|hemin-transporter	gnl\|CDD\|237337	PRK13289, PRK13289, NO-inducible flavohemoprotein.	2.40074e-105
NZ_CP045325.1\|WP_152519558.1\|1458704_1459406_+\|FCD-domain-containing-protein	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.45294e-38
NZ_CP045325.1\|WP_152515999.1\|1459510_1461031_+\|cytosine-permease	gnl\|CDD\|271404	cd11555, SLC-NCS1sbd_u1, uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	0
NZ_CP045325.1\|WP_152516002.1\|1464735_1465311_+\|ATP/GTP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	5.59175e-52
NZ_CP045325.1\|WP_152516003.1\|1465315_1465870_+\|pentapeptide-repeat-containing-protein	gnl\|CDD\|224276	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown].	1.34787e-19
NZ_CP045325.1\|WP_152516008.1\|1471689_1472256_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.04603e-10
NZ_CP045325.1\|WP_152516006.1\|1468474_1471192_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.86146e-70
NZ_CP045325.1\|WP_152519560.1\|1467652_1468129_-\|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	2.06489e-21
NZ_CP045325.1\|WP_173012174.1\|1452812_1456076_+\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
NZ_CP045325.1\|WP_152515994.1\|1451532_1452732_+\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	2.48861e-14
NZ_CP045325.1\|WP_173011981.1\|1463962_1464376_+\|roadblock/LC7-domain-containing-protein	gnl\|CDD\|224929	COG2018, COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only].	1.53465e-27
NZ_CP045325.1\|WP_152515997.1\|1456562_1457204_+\|nitroreductase-family-protein	gnl\|CDD\|380311	cd02062, Nitro_FMN_reductase, nitroreductase family protein. Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.	2.9533e-25
NZ_CP045325.1\|WP_152515998.1\|1457208_1457673_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	1.17406e-74

>NZ_CP045325.1|WP_152515999.1|1459510_1461031_+|cytosine-permease
MTTEAAPLTAGTHTGPAGTSIIKPSYHPRLTNEDLAPLVEQKWNWYNIFAFWMADVHSVGGYVTAGALFALGLTSWQVFVCLIVGICIVQLFCNLVAKPSQVHGLAYPVVARAAFGVMGANIAAIIRGSIAIAWYGVQTFLAAGSLTIVILKLFPGLQAYATDDNSFLGLSYVGYLSFAILWVIQAVVFWWGMEMVRWLCDISGPLIYTMMFILCIYMMARADWQISLTLSDKQLSTAEQLGAMLGAIALVVSYFAGPMLNFGDFSRYAKSFQQLKLGNLIGLPINFVVFSLLVVLTASATLPVFGEVMTNPIDTVQAIDTYTAVLLGGFTFVLATIGINIVANFVAPAFDFSNVNPQKISWRTGGMIAAVGSVLLTPWNWYNNDEAIFWTLGLLGALIGPLFGILIADYYLVRKQHIVVDDLFTMEESGTYWYQRGFNPVAIKATIVAGIASIGSVVIPKITGVVPTLGQYSWFIGCLVGFAAYYLFAYRANVANVAGRDVVEAG
>NZ_CP045325.1|WP_152519558.1|1458704_1459406_+|FCD-domain-containing-protein
MRRGPRFTAHLQNSFSQSGQSHVVDDLRHAILSGDQPPGTVIPVDEVAAHLGVSPIPVREALMTLIGEGLVERRPHVGYRVTTLTFEEFTDLYEVREVLEASALVSSVRNAGVDDDVQIRASHTELDTAIRRSDHRSFHTESRRLHLAMMRPSKMSRLISMYESAWNLTEPTSPMSHVSDEARRQFHGDHAEMIAAFVDRDVDALVAASHRHYEHLRAGFDPLRGDAELFRGP
>NZ_CP045325.1|WP_170311197.1|1458368_1458521_-|hypothetical-protein
MVRNGVEVATLAEASEIGDSPMMRAMSSEVVDAETFAGLVSIAAYETCLD
>NZ_CP045325.1|WP_152515998.1|1457208_1457673_-|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL
MFNVMFFSPRIAPNTGNAIRMVAGSGCALHLVEPLGFDLSEPKLRRAGLDYHDLASVTVHADLATAWQALMPARVYAFTAHASTSFAEVAYQPGDVLMFGPEPTGLDQATLADPHISATVRIPMLSGRRSLNLSNAAAVAVYEAWRQHGYAGAG
>NZ_CP045325.1|WP_152515997.1|1456562_1457204_+|nitroreductase-family-protein
MTLNLSADEVLTTTRSVRKRLDFDKPVPREVLMECLDIALQAPTGSNNQGWQWVFVEDADKKRALAEIYRTNATPYLAMEKPQTGDLRDQQRPRVEDSARYLNDHLHEVPVMLIPCLEGKPTDTPSGQSAGYWGSLLPAVWSFMLALRSRGLGSAWTTLHLLGDGERQAAELLGIPFDSYSQAGLFPVAYTKGTDFRPAKRLPAEQLTHWDTW
>NZ_CP045325.1|WP_152515996.1|1456125_1456539_-|TIGR03667-family-PPOX-class-F420-dependent-oxidoreductase
MAIELPQDVMQRLQSDHYGWLTTVARSGQPVPRLVWFYFDGADVLVYTEPGAAKVRHIGRHPRASLNLDSDGHGSGIIVVGGVTTVDAEGADPREDAPYWAKYADDAERIGLADSMDQYGLRLRISIDKVWTTPTPG
>NZ_CP045325.1|WP_173012174.1|1452812_1456076_+|error-prone-DNA-polymerase
MERVLNGRARRAGWPIDEQSGDGGDSPAWSRKRGEYRAPEVDRPPATGAVSVPYAELHAHSAYSFLDGASTPEELVEEAVRLGLRALALTDHDGLYGVVRFAEAARELDVATVFGAELSLSGVSRTDEPDPPGPHLLVLARGPEGYRRLSRQLAHAHLAGGEKGVLRYDVDALTEAAGGHWHILTGCRKGHVRQALASGGPAAAEAALADLVERFGRDRVSVELTHHGHPLDDERNAALAALAPRFGLGVVATTAAHIAGPDRARLAMAMGAIRARNSMDDAAGYLAPLGGSHLRSGAEMARIFPAGVVTAAAELGEQCAFGLALIAPKLPPFDVPDGHTEISWLRHLVAEGARDRYGPPERAPRAYAQIEHELAVIEQLGFPGYFLVVHDITRFCRHNDILAQGRGSAANSAVCYALKVTNVDPVANELLFERFLSPARDGPPDIDIDIESDLREKAIQYVYQRYGREYAAQVANVITYRGRSAVRDMARALGFSQGQQDAWSKQISRWNGLADSPDVEGIPEQVVDLAMQISNLPRHMGIHSGGMVICDRPIADVCPVEWARMENRSVLQWDKDDCAAIGLVKFDMLGLGMLSALHYCIDLVAEHKGLDVDLAKLDLGEAAVYEMLQRADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVHPYIKRRNGEEAVTYEHPSMESALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGSKRSTQKMRRLRGRFFDGMRELHGITGEVAERIYEKLEAFANFGFPESHSLSFASLVFYSSWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVVVHGPDVNASLAHATLENAGMEVRLGLGSVRHIGDELAEKLVEERKVHGPFTSLLDMTGRVQLSVPQTEALATAGALGCFGITRREGLWAAGAAAAERPDRLPGVGSSAQIPSLPGMTELELAVSDVWATGVSPDSYPTQFLRENLDEMGVVPADRLLRVPDGTRVLIAGAVTHRQRPATAQGVTFLNLEDETGMVNVLCSPGVWSRHRRLAQSASALVVRGVVQNATGAVTVVADRMGPLSMRVASKSRDFR
>NZ_CP045325.1|WP_152515994.1|1451532_1452732_+|diguanylate-cyclase
MFENLRHSAASAIAPALWRSDQYYWFTAVLAARGLQTVACRVVATCIVALGVVPMVLMASALGPQTAATRGLAVVVGLGCLGLAALWLRQHWPTRAQSLLSVFVGTVGIGVSALNVSSPIAGFLGATTYVLLTAFVVCFHSARFLVFTWTAGAVVVAVLFARLAPDDLALALCAAGVVVVLNVFIALVCRAAVTLVQPEAHHGDIEQVTGLLHRDAFYRGVATLLASRSRSDDQYLVMVAVNIDSFSLLMGLSGAQAGTRARVAVGQALRETVRHNAIVAHVSSGGFHDFLVADSFTTPDASPLVERIRGAIAGTPQKLTASIGVVCTPLPPLAAEPPDEVVDKLISVATTAIEQARMAGGNQVRYVLRPDLGEDPGEPGGDDWPDNGKDDWPDNGKSA
>NZ_CP045325.1|WP_152515993.1|1450536_1451400_+|MaoC-family-dehydratase-N-terminal-domain-containing-protein
MPIDPHAVGVTTDPQVFEWTDRDTLLYALGVGAGTADLAFTTENSHDVEQQVLPTYAVIACSPFAAATTIGSFDFSRLLHGSQAIRVFSPLPPAGRLSVVSEVADIQDKGPGKNAVVMLKATGSDPDTGEPVAESLMTLVIRGEGGFGGQPGQRPPAPEFPEREPDARLVLPMREDQALIYRLSGDRNPLHSDPWFAQLAGFPTPILHGLCSYGVAGRALVAELCDGDATRITAIAARFSSPVFPGETLTTSIWRQESGAAVFRTEASAPDGSNARLVLDDGVAEFR
>NZ_CP045325.1|WP_152515992.1|1449623_1450064_-|hypothetical-protein
MASKRDGGVPRQAIKLEPISTAAEMGAVSPKKSSQMSHLASSASASTNSSSDGSAALDRRRFDARQTEATAKLSAGEVDKAIELFCANIDAAMASAEWAFSIQARRGLGEAYLVTARSEEALHIFLAIAEEAEDETESSGLLGSAA
>NZ_CP045325.1|WP_173011981.1|1463962_1464376_+|roadblock/LC7-domain-containing-protein
MIPQPQSERDSLDWLVSRFARDVSGVSHAVLVSADGLLIAASEHMPGERADQLAAVTSGLASLSTGAAQLFDGGYVLQSVVEMENGYLLLMRVGDGSNLAALATRHSDIGQIGYEMAMLVERVGAVVSPQRRTPQHS
>NZ_CP045325.1|WP_152516001.1|1464383_1464755_+|DUF742-domain-containing-protein
MAGDGDRGTGEPSLVRPYTLTAGRTDAQVELALEAAVGVVAAVPPPRWPSTDVRCQILALCARRPSVAEIAAHLSLPLGVARVLVGDLVVQGYVQVHATLGEADTVDARRELIGRTLRGLRAL
>NZ_CP045325.1|WP_152516002.1|1464735_1465311_+|ATP/GTP-binding-protein
MASGRSSGQASTKIVISGGFGAGKTTFVGAVSEIVPLRTEALVTNASEGVDGLEATPSKSTTTVAMDFGRISLGDDLVLYLFGTPGQRRFWFMWDDLVRGAIGAIILVDTRRLADSFAAVDFFEARRLPFLVAVNEFDDAPRHRLSAVREALALSEQVPILRVDARSRESAKAALIAVTEYALSRLPAAAS
>NZ_CP045325.1|WP_152516003.1|1465315_1465870_+|pentapeptide-repeat-containing-protein
MRDVETDREFTGEDFRDEDLSRLRTERVVFTECDFSGVDMSESEHEGSAFRNCTFRRTSLWHSTFRHCTFLGSTFVECRMRPLTLVEVDFTLAVLGGADLRELDLSDCRLREAGLVGTDLRRAVLARCDLTGARVQGARMDGADLRGARTDASLWTTAGLRGAKVDVEQAVRFAAAHGLDIHGG
>NZ_CP045325.1|WP_152516004.1|1465965_1466442_+|Rrf2-family-transcriptional-regulator
MQLTRFTDLGLRAVMLLAAGEADGRRVTTGSIAAGANASENHIAKAVARLSDLGLVSARRGRVGGLSLTDEGRNASIGWLVRRLEGDREVVECGGSAPCPLVPACRLRRALADAKEAFYRELDHYTVNDLARGATLPVLAVPAVPRPQHPTTERTDHP
>NZ_CP045325.1|WP_152516005.1|1466438_1467656_+|hemin-transporter
MTETIVAAELEPAHAEVISATLPLVGAHIDEITREFYRRMFAAHPELLRNLFNRGNQAQGAQQRALAASIATFATHLVDPALPHPAELLSRIGHKHASLGVTADQYPIVHEHLFAAIVEVLGADTVTAEVAEAWDRVYWIMADTLIELERGLYRAAGVGEGDVYRRARVVSRVDDPSGTVLVTARTDGQRSGFAPGQYVSVGVTMPDGARQLRQYSVVNHPGTGGLLTFAVKPVVAAAGQPAGEVSSWIASNLRVGDILDVTVPFGDLPAPTGTEPLVLISAGIGATPMIGVLEYLAVEAPDARVHVLHADRSAQSHPLRGRQRELTDRLPNATLEVWYEDGADSPDAHAGLMDLDAVPLADDAQIYLCGNNGFVQAVRAQLVRRGVPASRVHCELFSPNDWLLG
>NZ_CP045325.1|WP_152519560.1|1467652_1468129_-|TetR/AcrR-family-transcriptional-regulator-C-terminal-ligand-binding-domain-containing-protein
MEGAANRAQLTPDFFRQTWGSERQLIVDALLNYTREITEMPDTGSLHGDLSALTHCIARYLNDPVGRRIARMMVVDSKSYEVDVETRAQFWATRQQAIDEILRRAQARGELRDDVRPTVVMQLVSSPLHTLALYSDRPATPDYCQAVADLVARAVTRV
>NZ_CP045325.1|WP_152516006.1|1468474_1471192_-|ATP-binding-cassette-domain-containing-protein
MSRPASPTLTVRYDGSTRTFAAGNDVVVGRDLRADVRIAHPLISRAHVVLRFEQGRWLAVDNGSLNGIYVNGRRVPTVDIVDGQQIHLGNPDGPLLTLDVGRHQGSAGRPPSTTSIRVAGRPSAPPVPPQTGYPSGARPYQSAPGTYPPSAPPPRPAPQAPPSGSYSPAPPSGPYTPAPPSGSYSTAPPSGSYSTAPPSGSYLTAPPSGSYSTAPPQPISSSEMESATMMGPAAAPRSADGNIATSMLRILRPGRPAETPPGSTKIGRAGDNDIVIPDVLASRHHATLVPTAAGTEIRDNRSINGTFVNGARVDTALLSDGDTVTIGNVDLVFHGGTLARRTETAADTATGGLDVRGLTWTIEGDKTLLDNISITARPGTLTAVIGPSGAGKSTFARQVAGYTHPTSGTVTFEGHDIHAEYASLRSRIGMVPQDDVVHGELTVNQALMYAAELRLPPDTTKEDRAQVVAQVLEELEMTKHADTRVDKLSGGQRKRASVALELLTGPSLLILDEPTSGLDPALDRQVMTMLRQLADAGRVVLVVTHSLTYLDVCDQVLLLAPGGMTAFYGPPSQIGPSMGTTNWADIFSSVAGDPTGAHERYLAQHGPPPPQPPTLAPSELGNPTRTSVRRQLSTVARRQVRLVVSDRGYFAFLMMLPFIMGVLSLSVPGDVGFGVPVTAIEGGPAPNEPGQILVMLNVGAIFMGTALTIRALIGERAIFRREQAVGLSTTAYLLAKVFVFTVFAVVQSAIVTSIAILGKGWGPGAVDSGAVIGNRSLELFVDIASTTVASAMVGLALSALAKSAEQIMPLLVVAVMSQLVFSGGMIPVTDRIVLDQLSWATPARWGFAASASTIDLIRLVPGPLTPQDRHWEHTSGAWLFDMAMLAAISVFYLGFVRWRIRLKPA
>NZ_CP045325.1|WP_152516007.1|1471244_1471640_-|nuclear-transport-factor-2-family-protein
MHTATAVAEQLYRALSDGDADALSAVLSADFHATVSAGMPHDVGGQHHGRVAMIAGVWGRIDATYDLAVVPSEFLEIGGGNKVVVLGTYRGTARDGTTRVDAAFAHVIAVRNGRITALQQITDTVRWSIPS
>NZ_CP045325.1|WP_152516008.1|1471689_1472256_+|TetR-family-transcriptional-regulator
MPRPARYSVDTLLDVAAELLAAEGPSAVTMSAVARAAGAPSGSVYHRFPTRAALCGELWVRTEERFQEALIDALSEDRDDAQQRCVAGALRIVQWCRENSTEAQVLLAGPHELGLDDWPDPVAGRRKRLQRKLRKAMAGLPDEEGRVSAAVIDVPGAIVRRHLRARQSIPASADTIVADCARALIPPG

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Crispr_ID: NZ_CP045325_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP045325_6

5750113-5750214

Orphan

Consensus_repeat	Method
ACGCCCACCTGCAGCCCACGTCGCTCTTCACCTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP045325_6

>merge|NZ_CP045325|6|5750113-5750214|CRISPRCasFinder
ACGCCCACCTGCAGCCCACGTCGCTCTTCACCTGCACCCACATCAACGCTGAACCAAGGCCACGTTGACGCCCACCTGCAGCCCACGTCGGTCTTCACCTGC

>NZ_CP045325|6|6|5750113-5750214|CRISPRCasFinder
ACGCCCACCTGCAGCCCACGTCGCTCTTCACCTGC	ACCCACATCAACGCTGAACCAAGGCCACGTTG
ACGCCCACCTGCAGCCCACGTCGGTCTTCACCTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP045325.1\|WP_152519404.1\|5757028_5757415_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP045325.1\|WP_152519392.1\|5742241_5742787_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367559
NZ_CP045325.1\|WP_152519407.1\|5759472_5760258_+\|TIGR03084-family-protein	unknown	unknown	gnl\|CDD\|274423
NZ_CP045325.1\|WP_152519391.1\|5741249_5742116_+\|DUF1707-domain-containing-protein	unknown	unknown	gnl\|CDD\|377959
NZ_CP045325.1\|WP_152519399.1\|5750338_5750779_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_CP045325.1\|WP_152519402.1\|5752909_5755786_-\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_CP045325.1\|WP_152519395.1\|5745317_5746214_+\|alpha/beta-fold-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_CP045325.1\|WP_152519403.1\|5755993_5756959_+\|LpqN/LpqT-family-lipoprotein	unknown	unknown	gnl\|CDD\|378485
NZ_CP045325.1\|WP_173012146.1\|5738185_5740642_-\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_CP045325.1\|WP_173012276.1\|5752204_5752858_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|181298
NZ_CP045325.1\|WP_152519408.1\|5760424_5760889_-\|pullulanase	unknown	unknown	unknown
NZ_CP045325.1\|WP_152519406.1\|5758178_5759462_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
NZ_CP045325.1\|WP_152519400.1\|5750796_5752137_-\|glycogen-debranching-protein	unknown	unknown	gnl\|CDD\|225942
NZ_CP045325.1\|WP_152519389.1\|5736425_5738048_-\|DUF2029-domain-containing-protein	unknown	unknown	gnl\|CDD\|227937
NZ_CP045325.1\|WP_152519405.1\|5757411_5758017_-\|YqgE/AlgH-family-protein	unknown	unknown	gnl\|CDD\|234694
NZ_CP045325.1\|WP_152519396.1\|5746345_5748430_+\|DUF839-domain-containing-protein	unknown	unknown	gnl\|CDD\|225752
NZ_CP045325.1\|WP_152519393.1\|5742875_5743967_+\|inositol-3-phosphate-synthase	unknown	unknown	gnl\|CDD\|132491
NZ_CP045325.1\|WP_173012147.1\|5740700_5741126_-\|DUF5318-domain-containing-protein	unknown	unknown	gnl\|CDD\|379953
NZ_CP045325.1\|WP_152519397.1\|5748567_5749377_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|213873
NZ_CP045325.1\|WP_152519394.1\|5744051_5745287_-\|enhanced-intracellular-survival-protein-Eis	unknown	unknown	gnl\|CDD\|234945

Protein	Function_ID	Function_description	E-value
NZ_CP045325.1\|WP_152519392.1\|5742241_5742787_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|367559	pfam03551, PadR, Transcriptional regulator PadR-like family. Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.	1.30291e-20
NZ_CP045325.1\|WP_152519407.1\|5759472_5760258_+\|TIGR03084-family-protein	gnl\|CDD\|274423	TIGR03084, conserved_hypothetical_protein, TIGR03084 family protein. This family, like pfam07398, belongs to the larger set of probable enzymes modeled by TIGRFAMs family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized. [Hypothetical proteins, Conserved].	2.82543e-121
NZ_CP045325.1\|WP_152519391.1\|5741249_5742116_+\|DUF1707-domain-containing-protein	gnl\|CDD\|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	4.97888e-16
NZ_CP045325.1\|WP_152519399.1\|5750338_5750779_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.75768e-18
NZ_CP045325.1\|WP_152519402.1\|5752909_5755786_-\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_CP045325.1\|WP_152519395.1\|5745317_5746214_+\|alpha/beta-fold-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.01526e-23
NZ_CP045325.1\|WP_152519403.1\|5755993_5756959_+\|LpqN/LpqT-family-lipoprotein	gnl\|CDD\|378485	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN. This family is conserved in Mycobacteriaceae and is likely to be a lipoprotein.	1.0146e-74
NZ_CP045325.1\|WP_173012146.1\|5738185_5740642_-\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	1.04319e-179
NZ_CP045325.1\|WP_173012276.1\|5752204_5752858_+\|SDR-family-oxidoreductase	gnl\|CDD\|181298	PRK08219, PRK08219, SDR family oxidoreductase.	2.89803e-111
NZ_CP045325.1\|WP_152519406.1\|5758178_5759462_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.44562e-28
NZ_CP045325.1\|WP_152519400.1\|5750796_5752137_-\|glycogen-debranching-protein	gnl\|CDD\|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	2.5203e-09
NZ_CP045325.1\|WP_152519389.1\|5736425_5738048_-\|DUF2029-domain-containing-protein	gnl\|CDD\|227937	COG5650, COG5650, Predicted integral membrane protein [Function unknown].	8.48273e-154
NZ_CP045325.1\|WP_152519405.1\|5757411_5758017_-\|YqgE/AlgH-family-protein	gnl\|CDD\|234694	PRK00228, PRK00228, YqgE/AlgH family protein.	7.7125e-79
NZ_CP045325.1\|WP_152519396.1\|5746345_5748430_+\|DUF839-domain-containing-protein	gnl\|CDD\|225752	COG3211, PhoX, Predicted phosphatase [General function prediction only].	5.60773e-174
NZ_CP045325.1\|WP_152519393.1\|5742875_5743967_+\|inositol-3-phosphate-synthase	gnl\|CDD\|132491	TIGR03450, mycothiol_INO1, inositol 1-phosphate synthase, Actinobacterial type. This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid.	0
NZ_CP045325.1\|WP_173012147.1\|5740700_5741126_-\|DUF5318-domain-containing-protein	gnl\|CDD\|379953	pfam17249, DUF5318, Family of unknown function (DUF5318). This family of unknown function is mostly found in Actinobacteria.	1.26085e-78
NZ_CP045325.1\|WP_152519397.1\|5748567_5749377_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|213873	TIGR03856, F420_MSMEG_2906, probable F420-dependent oxidoreductase, MSMEG_2906 family. This model describes a small family of enzymes in the bacterial luciferase-like monooxygenase family, which includes F420-dependent enzymes such as N5,N10-methylenetetrahydromethanopterin reductase as well as FMN-dependent enzymes. All members of this family are from species that produce coenzyme F420; SIMBAL analysis suggests that members of this family bind F420 rather than FMN. [Unknown function, Enzymes of unknown specificity].	8.85948e-175
NZ_CP045325.1\|WP_152519394.1\|5744051_5745287_-\|enhanced-intracellular-survival-protein-Eis	gnl\|CDD\|234945	PRK01346, PRK01346, enhanced intracellular survival protein Eis.	3.09311e-152

>NZ_CP045325.1|WP_152519397.1|5748567_5749377_+|LLM-class-F420-dependent-oxidoreductase
MTSSTRPIRIGVQLQPQHAPRYSHIRDAVRRCEDLGVDVAFNWDHFFPLYGDPDGAHYECWTMLGAWAEQTSRIEIGALVSCNSYRNPELLADMARTVDNISDGRLILGIGSGWKQKDYDEYGYEFGTAGSRLDELAAALPRIESRLGKLNPQPVRDIPILIGGQGEKKTLRMVAEHAHIWHGFTDASTYPGKAEVLDRHCADVGRDPGAIERSSGVPERSPEAAVEGAESLVALGVTLLTIGVNGPDYDLTVAEALCRWRDSRQSGVS
>NZ_CP045325.1|WP_152519396.1|5746345_5748430_+|DUF839-domain-containing-protein
MALVPLNLFVTHDGRSKRQHITCVYKCGDACSKPVPNRSDNEYFGDVVKALSRRSMLQAGGVAVLAVGAGSVLAACSSESQPAASSTASSAAPAEPPPGMNFASVAPNSEDAVVVADGYQQAVVISWGDPVLPGAPAFDVNNQTGDAQRGQFGFNNDFAGLLPIPGSRNRFLLVTNFEYVTPQFMFAGYDPDAPTREQFDVEIAAVGMGVVEVERTPDGLKPVMGRYNRRITADSPMTLTGPAAGSEFVKTAADPEGRTVAGTFANCAGGVTPWGTVLSGEENFQDYFGAAEGSPAPAPVQADRLDRYGVSLEPTELKWETFDPRFDLAATPNEPNRFGYVVELNPWDPNSAPVKHSAMGRLKHEGANIYLTDDGTVVAYTGDDERFDYMYKFVSSKKMRDPGPDMSNTAAMAHNMTILDEGTLYVAKLSSDIPPSEIDGSGELAPSGSFSGTGTWLPLLRSGPDGQAESLVDGITAQEVAVFTRMAADKAGATKMDRPEDFEANPKTGKVYVALTNNSKRGAPGEAGPDAANPRNDNKSGQVLEITDNHAGTDFTWDLLLVCGDPEAADTYYGGFDKSKVSPISCPDNLAFDSHGNLWISTDGNALDSNDGLFAVALDGPNRGEVKQFLTVPLGAETCGPVVTDDLVTVCVQHPGENDENSIDDPQSRWPEGGNGTARPSVVAVWKNNGQIGL
>NZ_CP045325.1|WP_152519395.1|5745317_5746214_+|alpha/beta-fold-hydrolase
MDDTDDELASLSEFIFLQENARQAGVSGPLPAAARIEHGPVSAVKFGDDAPRVVFLHGGGQNAHTWDTVIVGLGVPALAIDLPGHGRSAWRDDGDYGPKLNATAVEPMIREHAADADLVVGMSLGGLTALRLAVSAPELVRELVLVDVTPSAPERHTEMTDAQKGTVALVQGERTFPSFDAMLEVTVAAAPHRDRESLRRGVFHNAKRLEDGTWTWRYDSITKAEGFEGLWDDVPRLDTPTTLIRGANSFFVNDEDADAFARTAPGFRGVHVVADSGHSVQSDQPRVLTTLLRGILES
>NZ_CP045325.1|WP_152519394.1|5744051_5745287_-|enhanced-intracellular-survival-protein-Eis
MRPTSVVCQRREVTASSEVIVRGVEGGDWPGMALLAATCFGLWHPPDARQMWQSLVAPGCAVVACDGSDVVGTAVALDLEVTVPGGAVLPMAGVSWVAVSPTHRRRGVLRAMFAELHTRMGRFPIAGLEASEAGIYGRFGYGRATVAHRLTVERGSARFHDTVADPGGVRLAHAAENREQLEDIFERWRRQTPGGLHSPRPLWDEVLTDRPEARDGGSALFCLLHPDGFALYRVHGGERKDRIEITMFTAVTADAHVALWRTLLGMDLMDSVSVHTHPGEALPYLLTDPRLVRTTGVDDGLWLRLVDVPAALRARTYSADVAVVLDISDAVLGGGGRFALDVRDGRARCVPTTADADVHTDLSVLGSLYFGAHRASAFATAGRLRCADPRLVAALDAAFASDVPAQLGFGF
>NZ_CP045325.1|WP_152519393.1|5742875_5743967_+|inositol-3-phosphate-synthase
MTASNDVRVAIVGVGNCASSLVQGVQYYKDADENATVPGLMHVKLGQYHVRDVKFVAAFDVDAKKVGFDLSEAIFASENNTIKIADVPPTDVVVQRGPTLDGIGKYYADTIEISDADAVDVVQALKDAEVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDPEWAKKFADAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVALDRTYQLNVGGNMDFLNMLERTRLESKKVSKTQAVTSNLSGSLAGKVEDKNVHIGPSDHVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGVGGPVEAASAYLMKSPPKQLADDVAREQLENFIDGK
>NZ_CP045325.1|WP_152519392.1|5742241_5742787_+|helix-turn-helix-transcriptional-regulator
MLELAVLGLLLESPMHGYELRKRLTGLLGAFRAFSYGSLYPALRRMQADGLIVEDATGDGTLKVRRARRVYQLTDAGKQRFSELVADTGPQNFSDDGFGVHLAFFNRTPAEARMRILEGRRRQVEERREGLREAVARASSSFDRYTRQLHQLGLESSEREVKWLNELIAAEKSAQGHAEQT
>NZ_CP045325.1|WP_152519391.1|5741249_5742116_+|DUF1707-domain-containing-protein
MASGSSARRTSGTRAKDSDRNSTCAALDTALAEGQLSMTEHGERVKAATTAATLGELQMLVADLQIAAPPITLSPPEKRRLPVAPGWGIKAAIAGVLVVLGIAIGWGLYGNTPSPLNFTSDPGAKSDGIPAKVLTPPRQLQSLGGLNGLLEQMRQKFGDTSGYSLTVYPDYASLERPDPADARRVLRYSYRGGWGDPSTSAKDERDVLVDLAAFDVEEAVGLLRGAPETLGINAADVDNIYLSIDPSSDITAPPGAIDLSIYVSSEFGSGYVELNADGTVKHISYPSN
>NZ_CP045325.1|WP_173012147.1|5740700_5741126_-|DUF5318-domain-containing-protein
MRLQRQVVDYALRRRSLLAEVYSGRTGVSEVCDANPYLLRAAKFHGKPSSVMCPICRKEPLTLVSWVFGDHLGAVSGSARTAEELVLLATRYDEFSVHVVEVCRTCSWNHLVKSYVLGAIPPPKGSRRTQTARSRARTASE
>NZ_CP045325.1|WP_173012146.1|5738185_5740642_-|penicillin-binding-protein
MNARAPQHRPDGPRHRTPGPDLQRRPPGAPDDRRTAILPPVRDDVPAHLRDPIDSVKRALDGGPPKRPPPPPPTGGGGSGGDGPTGGPSWRDRINWRWVRRGSLIAAVVLIVLPLLTFGMAYMIVDVPKPGDIRTAQVSTILASDGSEIAKVVPPEGNRVDVSIDQIPVHVRDAVMAAEDRDFYSNPGFSFTGFLRAAKNNIFGGDLQGGSTITQQYVKNALVGDARSGVGGLVRKAKELVISTKMSGEWSKDQVLESYLNIIYFGRGAYGVAAAAQAYFAKPVEQLNVAEGALLAALIQRPSALDPAVDPDSAAARWNWVLDGMVEIGALSEQDRQAQVFPPTIPPDAASTQNQTTGPNGLIERQVINELLEIFDINEQTLNTEGLQIITTINPQAQAAAVDAADEYLEGQDPDMRTAIVSIDPKTGGVEAYYGGTDAAGFDFAQAGLPTGSSFKVFALVAALEQGMGLGYQVDSSPVTVNGIEISNVEGNSCGTCNIAEALKRSLNTSYYRLMLELENGPADVADAAHRAGIAESFPGVEHTLSEDGQGGPPNNGVVLGQYQSRVIDMASAYATLAASGVYHKPHFVQKVVNAEGTVLYDASQEDNTGEQRIEKDVADNVTAAMQPIAAYSGGHALAGGRPSAAKTGTNQLGDTGANRDAWMVGFTPSLSTAVWVGTTEGTKPLENQWGSPVYGSGLPSDIWKATMDGALDGTDTESFPKPEEIGGYAGVPAPPPPPPTSTEPPPPSETVIQPTLEIAPGITIPWGPPTTVPASPAPGAPPPPPDPAAVPPGPDGQPAPVNEPGVPVAPGAPPPPP
>NZ_CP045325.1|WP_152519389.1|5736425_5738048_-|DUF2029-domain-containing-protein
MNSPARPAGWESPARPAGDPRSLDDRDLPSRTDTIGAALAGTIGGPVGRHALIGRARFLTPLRVMMLIALVFLALGYSTKAACLQTTGSGTAEQRVANWENNRAYYELCYSDTVPLYTAELLNLGKFPYKSSWVETDDDGTPQITYDGEPAVRYMEYPVLTGIYQYLSMTVAKTYSALTRLVSVPVVAEVVMFFNIAAFGLALAWLTTLWATAMLAGPRRIWDAALVAASPIVIFQIFTNFDALATAFAAGALLAWARRRPVLAGVLIGLGVAAKLYPLLLLIPLTLLAIRAGRLREVGKTAAAAVGTWLLVNLPIMVLFPRGWSEFFRLNTRRGDDMDSLYNVVKSFTGWPGFDPDLGFWEPPTVLNAVSAALFAACCIVIGYIALTAPRRPRVAQLAFLVVAAFLLTNKVWSPQFSLWLVPLAVLALPHRRLLLAWMTIDMLVWVPRMLFLFGEQNMGLPEQAFTATVLLRDIAVIGLCALVIRQIYRPEQDLVRAGGAVDDPAGGVFDDAPDAPPRWLPDWLRPRPSVAATREPAPV
>NZ_CP045325.1|WP_152519399.1|5750338_5750779_+|MarR-family-transcriptional-regulator
MVEADAQVSELAGELQRVLSKVLAVLRHTGRTSTSGDLTLAQLSILLTLFDQGPMRMTELAAHERVRTPTTTVAIRRLEKLGLVKRSRDPSDLRAVLVDITPEGLAQHREALASRQAHLASLISKLNGEELEALAKALAPLERIAE
>NZ_CP045325.1|WP_152519400.1|5750796_5752137_-|glycogen-debranching-protein
MPHDPSFTPTQLAARAAYLLRGNDLGVMTTAAPLLYPHMWSWDAAFVSIGLAPLSVERAVVELDTLLSAQWRNGMIPHIVFANGVDGYFPGPARWACSALAANAPGARHTSGITQPPVHAIAVQRILDHARTRGRSTRAVAESFLDRRWAELVRWHRWLAECRDLNERGRVTLYHGWESGMDNSPRWDAAYANVVPGDVPEYQREDNKINTDASQRPSDLEYDRYLWLVEEMKAARYDDELMSKSVSFAVEDVFVSAILSVACQVLAEIGEDYKRPHADVRDLYAWADRFRSGVIETTDQRTGAARDYDVRADRWIATETVAQFAPLLCGGLPHDRERALLRLLEGPRFCGHPDLAYALIPSTSPVSRDFRPREYWRGPVWPVMTWLFAWCFARRGWAERSSFLRREGLRQASDGTFAEYYEPFTGEPLGSMQQSWTAAAVLDWLG
>NZ_CP045325.1|WP_173012276.1|5752204_5752858_+|SDR-family-oxidoreductase
MITGASGGLGSALADALAPTHTLLLAGRPSPRLDAVAERLGATTWPMDLADPDSLAAVVEPIVELDVLIHNAGVAYPGRVAETSVDEWRSSMAVNVIGAVALTLELLPALRAAQGHVVFINSGSGINPSPGLASYSASKFALRGFAGSLRADEPSLRVTSIHPGRIATAMQEDLVAYEGRDYDPDQFLSPQTVARVTADAVNAPRDAHVHEVIVRPR
>NZ_CP045325.1|WP_152519402.1|5752909_5755786_-|leucine--tRNA-ligase
MTETPTAQPAADADTPRYRYTAELAGDIERGWQQEWQARGTFDVANPVGSLAPADSAALPIDKRVPADKMFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFRMTGRNVLHALGFDAFGLPAEQYAIQTGTHPRTRTEANIVNFRRQLGRLGLGHDSRRSFSTTDVDYYKWTQWIFLQIYNAWFDPEIGRARPIAELIAEFDAGRRPLADGRDWSALSAGERADVVDGHRLVYLSDSVVNWCPGLGTVLANEEVTADGRSERGNFPVFRKRLRQWMMRITAYSDRLLEDLDVLDWPDKVKTMQRNWIGRSTGASVLFGTDAGDIEVFTTRPDTLFGATYMVLAPEHDLVDALAAPTWPDGVDARWTFGAATPVEAVAAYRAAIAAKSDLERQENKTKTGVFLGSYAVNPANGQQVPVFIADYVLAGYGTGAIMAVPSGDQRDWDFATEFGLPIVEVVSGGDVTEAAYTGDGELVNSGFLDGMTVGQAKAAITDKLAADGRGWARVEYKLRDWLFARQRYWGEPFPIVYDADGRAHPLPESLLPVELPDVPDYSPVLFDPDDAGSEPSPPLAKATDWVNVELDLGDGVQKYTRDTNVMPQWAGSSWYELRYTDPHNQDQMCAAENEAYWMGPRPAEHGPDDPGGVDLYVGGVEHAVLHLLYSRFWHKVLHDLGHVSSREPYRRLVNQGYIQAFAYTDPRGAYVPAAEVVERDGRFFWPGPDGEIEVTQEFGKIGKSLKNSVSPDEICDNYGADTLRVYEMSMGPLEASRPWATKDVVGAHRFLQRVWRLVVSEDSGATVATDDELDDATLRLLHRTIAGVADDYAALRNNTAAAKLIEFTNHLTKQSVTSRAALEPLVLMLAPLAPHLAEELWRRLGHEASLAHGPFPVADEAYLVEDSVEYPVQVNGKVRGRVTVAADADSDAVQAAALAEEKVVAFLDGRTPKKVIVVPGRLVNVVL
>NZ_CP045325.1|WP_152519403.1|5755993_5756959_+|LpqN/LpqT-family-lipoprotein
MSEITRQWRVMAGGIGACAAGVAGVLGLAGTTASAQPAIPQPPLPAPAPATVTQTVTVAPQAGEQALAQAGATPAAAGPAAVPAGISSPALPAPPPSTIAPATSGTLREFFAANNVTLEPQSSIGFRALNIVLPMPRGWEHVPDPNVPDAFAVIADRVGGNGLYTSNAQIVVYKLLGEFDPKEAISHGLVDSQQLPAWRSTDASLADFGGMPSSLIEGTYRENTMTLNTSRRHVIATSGADRYLVSLSVTTSVDQVVAAADATEAIVKGFKVSVPGATPPAPAAAPPAPAAPPAPAAPAAAPPAPAVPAAVTAPQMLGLQG
>NZ_CP045325.1|WP_152519404.1|5757028_5757415_+|hypothetical-protein
MFVAALVCLCAAAVTGALGAWFLTRPPSPDYVLRVLRAVAPTQLAAAAMLVAGAVIGFVAPAPTSTLLLILCVLGAVGTVAAGCWQAAKAVALTQARAQADRQAGGGCASESGGGCATCTLSCSDQKN
>NZ_CP045325.1|WP_152519405.1|5757411_5758017_-|YqgE/AlgH-family-protein
MGQPEDPEDFVAPAAHRVRAGTLLLANTDLLEPTFRRSVIYVVEHNDGGTLGVVLNRPSETAVYNVLPQWAQLATKPKTMFIGGPVKRDAALCLATLRVGVDHSAVAGLRHIQGRMVMVDLDADPATIAPMVEGVRIFAGYSGWTIGQLEGEIERDDWIVLSALPSDVLVEPQVDLWARVLRRQPMPLAMLATHPIDLSRN
>NZ_CP045325.1|WP_152519406.1|5758178_5759462_+|MFS-transporter
MPNLRALAHVWRSVRALPEFRRLLELRAVSQFGDGLFNAGLAGAILFNPEREAAPWAIAGAFAVLFLPYSLLGPFAGALLDRWDRRLVLIGANTGRLALILCVAALLSAGVGDLPILLGALIVNGFTRFVSSGISATLPHLVPREQVVAMNAVSVATGAAAAFFGAFFMLVPRWLFGADDTGGAAVIFLVSAPVAIALWLSVRFPAGMLGPDASARAVHGSVAYAVATGWVHGARTVVAVPTVAATLSGLAAHRMVFGLNTLLVLVLVRHVEAASVAGLGTTALFVAAAGTGSFLATAITPAAVQRWGRYTTPNAALAFAAVVQLCGVGLQLPVMVVCGFLLGAAGQVVKLCADTAMQVDVDDALRGHVFTVQDALFWIAFIGAIAAAAAVVPADGHAPAIALAGSGIYLAGLAAHATVGRRATPRG
>NZ_CP045325.1|WP_152519407.1|5759472_5760258_+|TIGR03084-family-protein
MAGAAPIVDDLRAESDALDELVADLPAQRWTTATPAAGWTIAHQIAHLLWTDRVALIAVEDEPGFTAVLGAAAEDPSGFVDVAAEELAATPPGELLADWRTTRTALHDALLTVAEGRKLPWFGPPMSAASMATARLMETWAHGLDVADALGVTLAPTARLRSIAHIGVRTRDFAFAVHGLTPPAAPFHVKLSAPAGAPDDVWTWGPEDAEQRVTGSAEHFCMLVTQRRPRADLDVRAEGPDAERWLGIAQAFAGPPGAGRG
>NZ_CP045325.1|WP_152519408.1|5760424_5760889_-|pullulanase
MDYCLGEPDGSATMWTVDGGPEVGGIDVDRDGLLDDMLLDTDGDGVADEALLDVDDDGTAELSVTDDGTGTWALSADRALRWFGLDGLEHLGTDVADLDGDGMAERLADADGDGLADRAFGAGSAWVDTDGDGRWDVRLGDTDDDGRADTVGSP

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP045325.1	221970-221993	1	0.958
NZ_CP045325_2	2.2\|216064\|39\|NZ_CP045325\|CRISPRCasFinder	216064-216102	39	NZ_CP045325.1	222264-222302	1	0.974
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NZ_CP045325.1	222435-222464	1	0.967

1. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to position: 221970-221993, mismatch: 1, identity: 0.958

gagatcacggccttgccgtcggtg	CRISPR spacer
gagatcacggcgttgccgtcggtg	Protospacer
*********** ************

2. spacer 2.2|216064|39|NZ_CP045325|CRISPRCasFinder matches to position: 222264-222302, mismatch: 1, identity: 0.974

cgcaccgtgatctgggcgcgagacccgttggtggccaac	CRISPR spacer
cgcaccgtgatctgggcacgagacccgttggtggccaac	Protospacer
*****************.*********************

3. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to position: 222435-222464, mismatch: 1, identity: 0.967

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
tagatgctggcgcggctgcccggtccgtcg	Protospacer
****.*************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP039913	Agrobacterium tumefaciens strain CFBP6625 plasmid pAtCFBP6625b, complete sequence	53326-53349	2	0.917
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP017294	Pseudomonas aeruginosa strain PA83 plasmid unnamed1, complete sequence	4252-4275	3	0.875
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP017294	Pseudomonas aeruginosa strain PA83 plasmid unnamed1, complete sequence	382674-382697	3	0.875
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	628259-628282	3	0.875
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	1993897-1993920	3	0.875
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NC_005241	Cupriavidus necator H16 megaplasmid pHG1, complete sequence	230229-230252	3	0.875
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP039289	Cupriavidus necator H16 plasmid pHG1, complete sequence	230228-230251	3	0.875
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1374857-1374880	3	0.875
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1050570-1050593	4	0.833
NZ_CP045325_1	1.1\|215770\|24\|NZ_CP045325\|CRISPRCasFinder	215770-215793	24	NC_016626	Burkholderia sp. YI23 plasmid byi_1p, complete sequence	825186-825209	4	0.833
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	CP054917	Streptomyces sp. NA02950 plasmid unnamed, complete sequence	59028-59057	5	0.833
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NZ_CP017941	Phyllobacterium zundukense strain Tri-48 plasmid unnamed1, complete sequence	533656-533685	6	0.8
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NZ_CP016619	Microvirga ossetica strain V5/3m plasmid unnamed2, complete sequence	628247-628276	6	0.8
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	513574-513603	7	0.767
NZ_CP045325_1	1.2\|215818\|36\|NZ_CP045325\|CRISPRCasFinder	215818-215853	36	KC292028	Halovirus HCTV-2, complete genome	5290-5325	8	0.778
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	MG869617	Polaromonas sp. E3S plasmid pE3SP1, complete sequence	5271-5300	8	0.733
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	MG869617	Polaromonas sp. E3S plasmid pE3SP1, complete sequence	52987-53016	8	0.733
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	MG869618	Polaromonas sp. E5S plasmid pE5SP1, complete sequence	5271-5300	8	0.733
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	398799-398828	8	0.733
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NZ_CP032326	Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence	97023-97052	8	0.733
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NC_042031	Mycobacterium phage Anaya, complete sequence	50665-50694	8	0.733
NZ_CP045325_1	1.2\|215818\|36\|NZ_CP045325\|CRISPRCasFinder	215818-215853	36	NZ_CP054620	Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence	287011-287046	9	0.75
NZ_CP045325_3	3.1\|216235\|30\|NZ_CP045325\|CRISPRCasFinder	216235-216264	30	NZ_AP022566	Mycolicibacterium alvei strain JCM 12272 plasmid pJCM12272, complete sequence	189833-189862	9	0.7
NZ_CP045325_1	1.2\|215818\|36\|NZ_CP045325\|CRISPRCasFinder	215818-215853	36	NC_006363	Nocardia farcinica IFM 10152 plasmid pNF2, complete sequence	86470-86505	10	0.722
NZ_CP045325_1	1.2\|215818\|36\|NZ_CP045325\|CRISPRCasFinder	215818-215853	36	NZ_LN868942	Nocardia farcinica strain NCTC11134 plasmid 5, complete sequence	39965-40000	10	0.722
NZ_CP045325_1	1.2\|215818\|36\|NZ_CP045325\|CRISPRCasFinder	215818-215853	36	NZ_CP031420	Nocardia farcinica strain W6977 plasmid unnamed2, complete sequence	9972-10007	10	0.722
NZ_CP045325_1	1.2\|215818\|36\|NZ_CP045325\|CRISPRCasFinder	215818-215853	36	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	705062-705097	11	0.694
NZ_CP045325_1	1.2\|215818\|36\|NZ_CP045325\|CRISPRCasFinder	215818-215853	36	NZ_CP016821	Rhodococcus sp. p52 plasmid pDF01, complete sequence	18303-18338	11	0.694

1. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NZ_CP039913 (Agrobacterium tumefaciens strain CFBP6625 plasmid pAtCFBP6625b, complete sequence) position: , mismatch: 2, identity: 0.917

gagatcacggccttgccgtcggtg	CRISPR spacer
gagatcacggccttggcgtcggag	Protospacer
*************** ****** *

2. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NZ_CP017294 (Pseudomonas aeruginosa strain PA83 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.875

gagatcacggccttgccgtcggtg	CRISPR spacer
ttgatcacggcattgccgtcggtg	Protospacer
  ********* ************

3. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NZ_CP017294 (Pseudomonas aeruginosa strain PA83 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.875

gagatcacggccttgccgtcggtg	CRISPR spacer
ttgatcacggcattgccgtcggtg	Protospacer
  ********* ************

4. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 3, identity: 0.875

gagatcacggccttgccgtcggtg	CRISPR spacer
tagatcacggccttgccgtccggg	Protospacer
 ******************* * *

5. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 3, identity: 0.875

gagatcacggccttgccgtcggtg	CRISPR spacer
tagatcacggccttgccgtccggg	Protospacer
 ******************* * *

6. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NC_005241 (Cupriavidus necator H16 megaplasmid pHG1, complete sequence) position: , mismatch: 3, identity: 0.875

gagatcacggccttgccgtcggtg	CRISPR spacer
aagatcaccgccttgccgtcgggg	Protospacer
.******* ************* *

7. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NZ_CP039289 (Cupriavidus necator H16 plasmid pHG1, complete sequence) position: , mismatch: 3, identity: 0.875

gagatcacggccttgccgtcggtg	CRISPR spacer
aagatcaccgccttgccgtcgggg	Protospacer
.******* ************* *

8. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 3, identity: 0.875

gagatcacggccttgccgtcggtg	CRISPR spacer
gagatcagggccttgccgtcgagg	Protospacer
******* *************. *

9. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 4, identity: 0.833

gagatcacggccttgccgtcggtg	CRISPR spacer
ttgaacacggccttgccgtcggta	Protospacer
  ** ******************.

10. spacer 1.1|215770|24|NZ_CP045325|CRISPRCasFinder matches to NC_016626 (Burkholderia sp. YI23 plasmid byi_1p, complete sequence) position: , mismatch: 4, identity: 0.833

gagatcacggccttgccgtcggtg	CRISPR spacer
gagatcacggccttgccggcgaaa	Protospacer
****************** **. .

11. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to CP054917 (Streptomyces sp. NA02950 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.833

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
ttggtgcaggcgtggctgcccggtccgtcg	Protospacer
* *..** ****.*****************

12. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to NZ_CP017941 (Phyllobacterium zundukense strain Tri-48 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
gaagcgcttgcgcggctgcccggaccgtca	Protospacer
 *..**** ************** *****.

13. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to NZ_CP016619 (Microvirga ossetica strain V5/3m plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.8

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
gagacgctggcgctgctgcgcggtcaatgg	Protospacer
 ************ ***** ***** .* *

14. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 7, identity: 0.767

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
cggtcgctggcgcggctgccggctccggtg	Protospacer
..* **************** * **** .*

15. spacer 1.2|215818|36|NZ_CP045325|CRISPRCasFinder matches to KC292028 (Halovirus HCTV-2, complete genome) position: , mismatch: 8, identity: 0.778

aaggtg-gtggcctcggcgcgggcgtcggtggcagtc	CRISPR spacer
-gggtgcgtggcctcggcgcaggcgtcgatggcctcg	Protospacer
 .**** *************.*******.****  .

16. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to MG869617 (Polaromonas sp. E3S plasmid pE3SP1, complete sequence) position: , mismatch: 8, identity: 0.733

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
aaggcgctggcgcggctgcccggcagcttt	Protospacer
 **.*******************.   *.

17. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to MG869617 (Polaromonas sp. E3S plasmid pE3SP1, complete sequence) position: , mismatch: 8, identity: 0.733

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
aaggcgctggcgcggctgcccggcagcttt	Protospacer
 **.*******************.   *.

18. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to MG869618 (Polaromonas sp. E5S plasmid pE5SP1, complete sequence) position: , mismatch: 8, identity: 0.733

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
aaggcgctggcgcggctgcccggcagcttt	Protospacer
 **.*******************.   *.

19. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 8, identity: 0.733

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
aacgcgctggcgcggctgttcggtccgcgc	Protospacer
 * .**************..*******.

20. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to NZ_CP032326 (Azospirillum brasilense strain MTCC4035 plasmid p5, complete sequence) position: , mismatch: 8, identity: 0.733

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
gggacgctggcgcggctgcgcggccggcgc	Protospacer
 .***************** ***.* *.

21. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to NC_042031 (Mycobacterium phage Anaya, complete sequence) position: , mismatch: 8, identity: 0.733

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
gagacgctgccgcggctgcccgtcgtgctg	Protospacer
 ******** ************ . .*..*

22. spacer 1.2|215818|36|NZ_CP045325|CRISPRCasFinder matches to NZ_CP054620 (Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence) position: , mismatch: 9, identity: 0.75

aaggtggtggcctcggcgcgggcgtcggtggcagtc	CRISPR spacer
cggatggtggcgtcggcgctggcgtcggtgcccaac	Protospacer
 .*.******* ******* ********** * . *

23. spacer 3.1|216235|30|NZ_CP045325|CRISPRCasFinder matches to NZ_AP022566 (Mycolicibacterium alvei strain JCM 12272 plasmid pJCM12272, complete sequence) position: , mismatch: 9, identity: 0.7

tagacgctggcgcggctgcccggtccgtcg	CRISPR spacer
atcaggcaggcgcggctgcccggtcctgat	Protospacer
   * ** ******************

24. spacer 1.2|215818|36|NZ_CP045325|CRISPRCasFinder matches to NC_006363 (Nocardia farcinica IFM 10152 plasmid pNF2, complete sequence) position: , mismatch: 10, identity: 0.722

aaggtggtggcctcggcgcgggcgtcggtggcagtc	CRISPR spacer
cgaccggtgacctcggcgcgggcgtcgctggccgag	Protospacer
 .. .****.***************** **** *

25. spacer 1.2|215818|36|NZ_CP045325|CRISPRCasFinder matches to NZ_LN868942 (Nocardia farcinica strain NCTC11134 plasmid 5, complete sequence) position: , mismatch: 10, identity: 0.722

aaggtggtggcctcggcgcgggcgtcggtggcagtc	CRISPR spacer
cgaccggtgacctcggcgcgggcgtcgctggccgag	Protospacer
 .. .****.***************** **** *

26. spacer 1.2|215818|36|NZ_CP045325|CRISPRCasFinder matches to NZ_CP031420 (Nocardia farcinica strain W6977 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.722

aaggtggtggcctcggcgcgggcgtcggtggcagtc	CRISPR spacer
cgaccggtgacctcggcgcgggcgtcgctggccgag	Protospacer
 .. .****.***************** **** *

27. spacer 1.2|215818|36|NZ_CP045325|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 11, identity: 0.694

aaggtggtggcctcggcgcgggcgtcggtggcagtc	CRISPR spacer
ccgtcggtggccacggcgcggtcgtcggtgggcacg	Protospacer
  * .******* ******** *********  ..

28. spacer 1.2|215818|36|NZ_CP045325|CRISPRCasFinder matches to NZ_CP016821 (Rhodococcus sp. p52 plasmid pDF01, complete sequence) position: , mismatch: 11, identity: 0.694

aaggtggtggcctcggcgcgggcgtcggtggcagtc	CRISPR spacer
gcagtgttggcgtcggcgcgggcgtcggtagagaca	Protospacer
. .*** **** *****************.* ...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1336563 : 1352330

Streptococcus_phage(50.0%)

transposase,integrase

attL 1340356:1340377|attR 1346403:1346424

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152515913.1\|1336563_1337792_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_152515915.1\|1338785_1339115_+	hypothetical protein	NA	NA	NA	NA
1340356:1340377	attL	NA	NA	NA	NA
WP_152515916.1\|1340960_1342142_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5S7K9	Streptococcus_phage	1.1e-06	54.3
WP_152515917.1\|1342138_1344295_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_152515918.1\|1344291_1344735_+\|transposase	transposase	NA	NA	NA	NA
WP_152519549.1\|1345133_1346351_-\|transposase	IS21 family transposase	NA	NA	NA	NA
WP_152515919.1\|1346930_1347278_-	hypothetical protein	NA	NA	NA	NA
1346403:1346424	attR	NA	NA	NA	NA
WP_152515920.1\|1347682_1347874_+	ferredoxin	NA	NA	NA	NA
WP_152515921.1\|1347900_1349133_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
WP_152515922.1\|1349608_1350688_+	CoA transferase	NA	NA	NA	NA
WP_152515923.1\|1351091_1352330_-\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.8e-110	53.9

DBSCAN-SWA_2

1374082 : 1411733

Burkholderia_virus(37.5%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152515942.1\|1374082_1375368_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.7e-58	50.0
WP_152515943.1\|1376070_1377222_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_152515944.1\|1377223_1378375_-	acetyl-CoA C-acetyltransferase	NA	NA	NA	NA
WP_152515945.1\|1378449_1378821_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_152519552.1\|1378851_1379646_+	TIGR03857 family LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
WP_152519553.1\|1380398_1381373_-	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_152515946.1\|1381837_1382605_-	glucose 1-dehydrogenase	A0A0M4JSW6	Mollivirus	1.6e-11	26.8
WP_152519554.1\|1382739_1383420_-	TetR family transcriptional regulator	NA	NA	NA	NA
WP_152515947.1\|1383548_1384889_+	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_152515948.1\|1384888_1385911_+	phosphotransferase	NA	NA	NA	NA
WP_152515949.1\|1385972_1387079_-	NDMA-dependent alcohol dehydrogenase	E3SJ82	Synechococcus_phage	1.0e-32	29.4
WP_152515950.1\|1387160_1388816_-	AMP-binding protein	A0A2H4PQU7	Staphylococcus_phage	6.5e-47	31.2
WP_152515951.1\|1388812_1389250_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_152515952.1\|1389246_1390536_-	cytochrome P450	NA	NA	NA	NA
WP_173011977.1\|1390700_1391669_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_152515954.1\|1392259_1393057_+	alcohol dehydrogenase catalytic domain-containing protein	NA	NA	NA	NA
WP_064961518.1\|1394181_1395501_+\|transposase	IS256 family transposase	A0A2P1JQX9	Mycobacterium_phage	2.0e-232	92.5
WP_173011978.1\|1398129_1398657_+	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_152515957.1\|1398646_1399786_+	phosphotransferase	NA	NA	NA	NA
WP_152515958.1\|1399810_1400500_+	VOC family protein	NA	NA	NA	NA
WP_152515942.1\|1400947_1402233_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.7e-58	50.0
WP_152515959.1\|1402585_1403821_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	9.7e-80	42.5
WP_152515960.1\|1404419_1404785_+	hypothetical protein	NA	NA	NA	NA
WP_152515942.1\|1405014_1406300_-\|transposase	IS3 family transposase	Q8W6R2	Burkholderia_virus	1.7e-58	50.0
WP_152515961.1\|1406354_1406615_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_152515913.1\|1410505_1411733_+\|transposase	IS3 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

5183906 : 5245739

Tupanvirus(20.0%)

tRNA,protease,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_152518938.1\|5183906_5186450_-\|protease	ATP-dependent protease ATP-binding subunit ClpC	K4FB40	Cronobacter_phage	5.6e-130	39.7
WP_152518939.1\|5186738_5187080_-	Lsr2 family protein	A0A2D1GPL8	Mycobacterium_phage	7.9e-16	42.4
WP_152518940.1\|5187181_5188696_-\|tRNA	lysine--tRNA ligase	A0A2K9L3L6	Tupanvirus	1.7e-70	35.2
WP_152518941.1\|5188719_5189976_+	alanine racemase	NA	NA	NA	NA
WP_152518942.1\|5189992_5190808_-	type III pantothenate kinase	NA	NA	NA	NA
WP_152518943.1\|5190813_5191221_-	aspartate 1-decarboxylase	NA	NA	NA	NA
WP_152518944.1\|5191220_5192165_-	pantoate--beta-alanine ligase	NA	NA	NA	NA
WP_152518945.1\|5192161_5193121_-	DUF2520 domain-containing protein	NA	NA	NA	NA
WP_152518946.1\|5193215_5194499_-	hypothetical protein	NA	NA	NA	NA
WP_152518947.1\|5194576_5195053_-	DUF3180 family protein	NA	NA	NA	NA
WP_152518948.1\|5195052_5195574_-	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	NA	NA	NA	NA
WP_152518949.1\|5195581_5195962_-	dihydroneopterin aldolase	NA	NA	NA	NA
WP_152519920.1\|5195958_5196771_-	dihydropteroate synthase	S4W084	Pandoravirus	6.1e-22	31.2
WP_152518950.1\|5196815_5197424_-	GTP cyclohydrolase I FolE	E7DN69	Pneumococcus_phage	7.2e-44	51.5
WP_152518951.1\|5197463_5199818_-\|protease	ATP-dependent zinc metalloprotease FtsH	C7U047	Ostreococcus_tauri_virus	1.6e-107	46.6
WP_173012122.1\|5199969_5200935_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_152518952.1\|5200945_5201692_+	SIMPL domain-containing protein	NA	NA	NA	NA
WP_152518953.1\|5201684_5203928_-	molybdopterin-dependent oxidoreductase	NA	NA	NA	NA
WP_152518954.1\|5203947_5204526_-	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	6.1e-08	26.9
WP_152518955.1\|5204535_5205534_-\|tRNA	tRNA lysidine(34) synthetase TilS	NA	NA	NA	NA
WP_152518956.1\|5205512_5206598_-\|protease	zinc-dependent metalloprotease	NA	NA	NA	NA
WP_152518957.1\|5206594_5207962_-	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
WP_152518958.1\|5208109_5208595_+	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	2.1e-30	45.8
WP_152518959.1\|5208778_5209300_+	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	NA	NA	NA	NA
WP_152518960.1\|5209369_5210410_+	allantoicase	NA	NA	NA	NA
WP_170311184.1\|5210414_5211443_-	TerC/Alx family metal homeostasis membrane protein	A0A291LBC5	Escherichia_phage	3.8e-37	33.2
WP_152518961.1\|5211659_5215574_+	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	1.6e-35	24.2
WP_152518962.1\|5215570_5216911_+	M1 family peptidase	NA	NA	NA	NA
WP_152518963.1\|5216907_5218149_+	hypothetical protein	NA	NA	NA	NA
WP_152518964.1\|5218195_5219173_+	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	1.1e-41	35.2
WP_173012123.1\|5219178_5220945_+	hypothetical protein	NA	NA	NA	NA
WP_173012124.1\|5221039_5222227_-	ATP-binding protein	NA	NA	NA	NA
WP_152518966.1\|5222452_5223685_-	DNA polymerase III subunit delta'	NA	NA	NA	NA
WP_152518967.1\|5223767_5225351_+	HAMP domain-containing protein	A0A1B1IWY2	uncultured_Mediterranean_phage	1.0e-17	32.3
WP_152518968.1\|5225347_5228158_-	type I DNA topoisomerase	J3E777	Acanthamoeba_polyphaga_lentillevirus	8.7e-100	31.9
WP_152518969.1\|5228292_5228883_-	hypothetical protein	NA	NA	NA	NA
WP_003882601.1\|5229031_5229235_-	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	1.5e-14	56.2
WP_152518970.1\|5229596_5231945_+	DEAD/DEAH box helicase	NA	NA	NA	NA
WP_152518971.1\|5231984_5233073_+	DUF5593 domain-containg protein	NA	NA	NA	NA
WP_152518972.1\|5233030_5233627_-	hypothetical protein	NA	NA	NA	NA
WP_152518973.1\|5233747_5233948_-	DUF4244 domain-containing protein	NA	NA	NA	NA
WP_152518974.1\|5233969_5234542_-	type II secretion system F family protein	NA	NA	NA	NA
WP_152518975.1\|5234538_5235327_-	type II secretion system F family protein	NA	NA	NA	NA
WP_152518976.1\|5235323_5236496_-	TadA family conjugal transfer-associated ATPase	NA	NA	NA	NA
WP_152518977.1\|5236492_5237590_-	AAA family ATPase	NA	NA	NA	NA
WP_152518979.1\|5238021_5238879_+	HAD-IB family hydrolase	NA	NA	NA	NA
WP_173012125.1\|5239339_5240080_-	oxidoreductase	NA	NA	NA	NA
WP_152518981.1\|5240239_5242201_+	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	9.1e-80	37.8
WP_152518982.1\|5242236_5242941_-\|protease	serine protease	NA	NA	NA	NA
WP_152518983.1\|5243087_5243588_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_152518984.1\|5243587_5244559_+	alpha/beta fold hydrolase	NA	NA	NA	NA
WP_152518985.1\|5244551_5245739_-\|protease	acid resistance serine protease MarP	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP045327

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NZ_CP045325

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection